The 60th Japanese Peptide Symposium
November 8 (Wednesday)
9:30–9:40

Opening Remarks (Hidehito Mukai)

9:40–10:57

Young Investigator’s Oral Presentations (8 min talk, 2 min discussion, 1 min speaker exchange)
Session 1 (chairs: Gosuke Hayashi, Masaya Denda)

Y-01

Iron-catalyzed biomimetic dimerization of tryptophan-containing peptides
Kenta Noda1, Soichiro Sato1, Hiroyuki Hakamata1, Eunsang Kwon2, Nagao Kobayashi3,4, Hirofumi Ueda1,
Hidetoshi Tokuyama1 (1Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department ofChemistry and Research and Analytical Center for Giant Molecules, Tohoku University, 3Graduate Schoolof Sciences, Tohoku University, 4Faculty of Textile Science and Technology, Shinshu University)

Y-02

Development of S-[2-aminovinyl]-3-methylcysteine construction using photoreaction
Masaya Kumashiro, Kosuke Ohsawa, Takayuki Doi (Graduate School of Pharmaceutical Sciences, Tohoku
University)

Y-03

Development of intermolecular acylation protocol of threonine by a late-stage sequential acyl transfer–
desulfurization
Daiki Sato, Chiho Shinozaki, Masaya Denda, Akira Otaka (Institute of Biomedical Sciences and Graduate
school of Pharmaceutical Sciences, Tokushima University)

Y-04

Semi-synthetic study of glycoprotein interleukin-6 via a novel folding-assisted thioesterification method
Yanbo Liu1, Ryo Okamoto1,2, Yuta Maki1,2, Yasuhiro Kajihara1,2 (1Graduate School of Science, Osaka
University, 2Forefront Research Center, Osaka University)

Y-05

Development of novel amino acids containing MPE-type auxiliary for sequential ligation of multiple
peptidesYoshinori Taguchi1, Kohei Sato2, Nobuyuki Mase2, Tetsuo Narumi1,2 (1Graduate School of Medical
Photonics, Shizuoka University, 2Graduate School of Integrated Science and Technology, Shizuoka
University)

Y-06

The synthesis of CYP121A1 inhibitors as potential treatments for tuberculosis
Denham Hopper, Craig Hutton (The Department of Chemistry, The University of Melbourne)

Y-07

Discovery and characterization of a short peptide possessing a latent warhead undergoing spontaneous
intramolecular cyclization in the aqueous environment
Riku Katsuki, Masumi Taki (Graduate School of Informatics and Engineering, the University of ElectroCommunications (UEC))

10:57–11:15

Break

11:15–12:43

Young Investigator’s Oral Presentations (8 min talk, 2 min discussion, 1 min speaker exchange)
Session 2 (chairs: Hiroshi Inaba, Yoshiro Chuman)

Y-08

GalNAc-conjugated helical peptides as tissue-selective carrier

Takahito Ito1,2, Takashi Misawa2, Yosuke Demizu1,2,3 (1Graduate School of Medical Life Science,
Yokohama City University, 2National Institute of Health Sciences, 3Graduate School of Medicine,
Dentistry and Pharmaceutical Sciences, Okayama University)
Y-09

PNA twin probe detects target nucleic acids
Sakura Tsuchitani1, Koki Ishii1, Yutaka Ouchi1, Mizuki Kitamatsu1, Hajime Shigeto2, Shohei Yamamura2,
Yoshihide Hattori3 (1Department of Applied Chemistry, Kindai University, 2Health and Medical ResearchInstitute, National Institute of Advanced Industrial Science and Technology (AIST), 3Research Center of
BNCT, Osaka Metropolitan University)

Y-10

Intracellular bottom-up reconstruction of liquid droplet by fusion of YK amphiphilic peptide tag
Masahiro Hashimoto1, Takayuki Miki1,2, Hiroki Takahashi1, Sae Nakayama1, Tadaomi Furuta1, Hisakazu
Mihara1 (1School of Life Science and Technology, Tokyo Institute of Technology, 2Graduate School ofEngineering, The University of Tokyo)

Y-11

Development and application of conformationally restricted cyclic peptides with high passive
permeabilty
Yuta Takashima1, Yurina Araki2, Yuki Yamazaki1, Ikuhiko Nakase2, Satoshi Shuto1, Mizuki Watanabe1(1Faculty of Pharmaceutical Sciences, Hokkaido University, 2Graduate School of Science, Osaka
Metropolitan University)

Y-12

Construction and screening of a natural product-inspired prenylated thiopeptide library
Sota Uchida, Yuki Goto, Hiroaki Suga (Department of Chemistry, Graduate School of Science, The
University of Tokyo)

Y-13

Improvement of the metabolic stability of a backbone-alanyl peptoid in liver microsome
Hiroka Kobayashi1, Eri Watanabe2, Jumpei Morimoto1, Shinsuke Sando1 (1Graduate School of Engineering,
The University of Tokyo, 2Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Y-14

Development of nanobody for specific binding on antigen-high-expressing cells by affinity optimizationand tandem trimerization
Suwandi Onggono, Tetsuya Kadonosono (School of Life Science and Technology, Tokyo Institute ofTechnology)

Y-15

Development of biocompatible D-peptide conjugates for photooxygenation of myostatin
Shuko Amber Murano1, Hideyuki Okamoto1, Kaoru Ikekawa1, Masahiro Katsuyama1, Sho Konno1,
Akihiro Taguchi1, Kentaro Takayama1,2, Atsuhiko Taniguchi1, Yoshio Hayashi1 (1Tokyo University of
Pharmacy and Life Sciences, 2Kyoto Pharmaceutical University)

12:43–14:00

Lunch Break & Luncheon Seminar (12:50–13:50, Conference Room 305, Piazza Omi)

14:00–15:17

Young Investigator’s Oral Presentations (8 min talk, 2 min discussion, 1 min speaker exchange)
Session 3 (chairs: Daisuke Fujiwara, Taku Yoshiya)

Y-16

Physiological roles and regulatory mechanisms of mitocryptide-2 in sterile or infectious innate immune
responses

Hakuu Fujiwara, Hirokazu Tanaka, Hayato Katabuchi, Takanori Yamada, Tatuya Hattori, Yosiaki Kiso,
Shinta Nomura, Hidehito Mukai (Graduate School of Bio-Science, Nagahama Institute of Bio-Science andTechnology)
Y-17

Identification of disulfide-rich peptides from Habu venom to regulate the activity of integrin
Takuro Sato, Eugene Futai, Masafumi Hidaka, Tomohisa Ogawa (Laboratory of Enzymology, Graduate
School of Agricultural Science, Tohoku University)

Y-18

Construction of enveloped viral replica equipped with spike protein derived from SARS-CoV-2
Hiroto Furukawa1, Keisuke Nakamura2, Shin-ichi Sawada2, Hiroshi Inaba1, Yoshihiro Sasaki2, Kazunari
Akiyoshi2, Kazunori Matsuura1 (1Graduate School of Engineering, Tottori University, 2Graduate School ofEngineering, Kyoto University)

Y-19

Surface functionalization of a virus-like architecture with a peptide tag
Daiki Kanayama1, Naohiro Terasaka2, Hiroaki Suga1 (1Graduate School of Science, The University ofTokyo, 2Earth-Life Science Institute, Tokyo Institute of Technology)

Y-20

Mechanism study of endothelial cell toxicity medeiated by histone H4 via membrane-disrupting peptides
Zihao Wang, Mikako Hamabe, Takafumi Furuhata, Akimitsu Okamoto (Department of Chemistry andBiotechnology, Graduate School of Engineering, the University of Tokyo)

Y-21

Improvement of the cellular internalization of the canonical CPP-protein conjugates by ε-poly-L-lysine
Yamato Takeuchi, Fumihito Hasebe, Chitose Maruyama, Yoshimitsu Hamano (Department of Bioscienceand Biotechnology, Fukui Prefectural University)

Y-22

Discovery of a specific triple-helical ligand for integrin alpha2 beta1 that show metal ion-independentinteraction
Shinsuke Shibata1, Kazunori K Fujii1, Ryo Masuda2, Takaki Koide1,2 (1Department of Chemistry andBiochemistry, School of Advanced Science and Engineering, Waseda University, 2Waseda ResearchInstitute for Science and Engineering, Waseda University)

15:17–15:30

Break

15:30–16:39

Young Investigator’s Oral Presentations (8 min talk, 2 min discussion, 1 min speaker exchange)& Invited Lecture
Session 4 (chairs: Rui Kamada, Mizuki Watanabe)

Y-23

Two dimensional nanosheet structures consisting of amphiphilic diblock peptoids with crystalline
aliphatic side chains
Renya Fukuda1, Yota Okuno2,3, Tomoki Nishimura4, Akinori Kuzuya2,3, Yasuhiko Iwasaki2,3 (1Graduate
School of Science and Engineering, Kansai University,

2

Faculty of Chemistry, Materials andBioengineering, Kansai University, 3ORDIST, Kansai University, 4Faculty of Textile of Science
Technology, Shinshu University)
Y-24

Temperature-responsive behavior of branched molecules bearing pentapeptide units of elastin-like
peptides (FPGVG)nNaoki Tanaka1, Keitaro Suyama2, Keisuke Tomohara2, Takeru Nose1,2 (1Department of Chemistry, Facultyand Graduate School of Science, Kyushu University, 2Faculty of Arts and Science, Kyushu University)

Y-25

Chemical synthesis of mirror-image human serum albumin domain III for mirror-image screening
Naoya Iwamoto1, Shinsuke Inuki1, Hiroaki Ohno1, Shinya Oishi2 (1Graduate School of Pharmaceutical
Sciences, Kyoto University, 2Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University)

Y-26

γ-Substituted proline-accelerated diketopiperazine formation for tag-attached peptide thioester
synthesis
Koki Nakatsu1, Gosuke Hayashi1, Hiroshi Murakami1,2 (1Graduate School of Engineering, Nagoya
University, 2Institute of Nano-Life-Systems, Nagoya University)

K-1

Selective Degradation of Transcription Coactivator SRC-1 via the N-degron Pathway
Yeongju Lee1, Jiwon Heo2, G-One Ahn3, Jun-Seok Lee4, Hyun Kyu Son2, Hyun-Suk Lim1 (1Department ofChemistry and Division of Advanced Materials Science, Pohang University of Science and Technology,
2

School of Life Sciences and Biotechnology, Korea University, 3Research Institute for Veterinary Science

and College of Veterinary Medicine, Seoul National University, 4Molecular Recognition Research Center,
Korea Institute of Science and Technology (KIST), Korea)
16:39–16:50

Break

16:50–17:35

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 5 (chairs: Akira Shigenaga, Tetsuo Narumi)

O-01

Photo-induced conformational change in cyclic peptides induced by complete cis-to-trans conversion of
benzanilide derivatives
Yuko Otani, Asami Ichinose, Xihong Wang, Zhihan Huang, Shuyi Song, Akitomo Kasahara, Mayumi Ishii,
Eri Watanabe, Kayoko Kanamitsu, Kempei Tai, Hiroyuki Kusuhara, Takumi Ueda, Koh Takeuchi,
Tomohiko Ohwada (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

O-02

Development of convergent synthesis for peptidomimetic based on a chloroalkene dipeptide isostere andits application to a cyclic peptide
Takuya Kobayakawa, Chika Azuma, Kenichi Yamamoto, Kohei Tsuji, Hirokazu Tamamura (Institute of
Biomaterials and Bioengineering, Tokyo Medical and Dental University)

O-03

Peptide epimerase responsible for D-amino acid introduction in poly-γ-glutamic acid biosynthesis
Hinata Kato1, Moeka Sakuta1, Takeshi Tsunoda2, Yu Nakashima3, Hiroyuki Morita3, Yasushi Ogasawara2,
Tohru Dairi2 (1Graduate School of Chemical Science and Engineering, Hokkaido University, 2Graduate
School of Engineering, Hokkaido University, 3Institute of Natural Medicine, University of Toyama)

17:40–19:10

Poster Presentations
Session 1 (1P-001–1P-053)
Odd numbers: 17:40–18:25
Even numbers: 18:25–19:10

November 9 (Thursday)
9:30–10:30

60th Anniversary of Japanese Peptide Symposium: Development of Peptide Science
Session 6 (chairs: Akira Otaka, Motoyoshi Nomizu)

I-1

Sixty years of peptide science in Japan
Saburo Aimoto (Osaka University)

I-2

Peptide materials from self-assembly and their use in therapy
Joel P. Schneider (Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute,
USA)

I-3

Innovative strategies for biomaterials: modifying surfaces with biomimetic coatings
Annette G. Beck-Sickinger (Institute of Biochemistry, Faculty of Life Sciences, Leipzig University,
Germany)

10:30–10:45

Break

10:45–12:00

60th Anniversary of Japanese Peptide Symposium: Development of Peptide Science
Session 7 (chairs: Ikuo Fujii, Shiro Futaki)

I-4

Applications of cyclotides in agriculture and medicine
David J Craik (Institute for Molecular Bioscience, Australian Research Council Centre of Excellence forInnovations in Peptide and Protein Science, The University of Queensland, Australia)

I-5

From serpin A1 to KP1 protecting dermal collagen from degradation: the story of a peptide-based
cosmeceutical into the market and beyond
Anna Maria Papini1,2, Fosca Errante1,3, Lisa Giovannelli3, Paolo Rovero1,3 (1Interdepartmental ResearchCentre of Peptide and Protein Chemistry and Biology, University of Florence, Italy, 2Department ofChemistry “Ugo Schiff”, University of Florence, Italy, 3Department of NEUROFARBA, University of
Florence, Italy)

I-6

Designer pepetidomemetics to study and modualate multifacted toxicity of Alzheimer’s disease
T. Govindaraju (Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre forAdvanced Scientific Research (JNCASR), India)

12:00–13:20

Lunch Break & Luncheon Seminar (12:10–13:10, Conference Room 305, Piazza Omi)

13:20–14:30

60th Anniversary of Japanese Peptide Symposium: Development of Peptide Science
Session 8 (chairs: Hironobu Hojo, Hidehito Mukai)

I-7

Characterization of mixed-helical unnatural peptides and their applications
Soo Hyuk Choi (Department of Chemistry, Yonsei University, Korea)

I-8

Glycosylation of tumor-associated mucin peptides and their antitumor properties
Joseph J. Barchi Jr., Caitlin Strain, Achyut Dahal (Chemical Biology Laboratory, Center for Cancer
Research, National Cancer Institute at Frederick, USA)

I-9

Expression of novel functional polypeptides “r-peptides” encoded by latent OFFs in bacterial ribosomal

RNAs in response to antibiotics
Kazuyasu Sakaguchi (Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science,
Hokkaido University)
14:30–14:45

Break

14:45–15:30

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 9 (chairs: Yuki Goto, Kohei Tsuji)

O-05

Evaluation of the effect of an amide-to-ester substitution on membrane permeability and conformational
states of cyclic peptides
Jumpei Morimoto1, Yuki Hosono1, Satoshi Uchida1, Moe Shinkai1, Masatake Sugita2,3, Takumi Ueda4,
Kayoko Kanamitsu4, Mayumi Ishii4, Koh Takeuchi4, Yutaka Akiyama2,3, Scott R. Lokey5, Shinsuke Sando1(1Graduate School of Engineering, The University of Tokyo, 2School of Computing, Tokyo Institute ofTechnology, 3Middle-Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute ofTechnology, 4Graduate School of Pharmaceutical Sciences, The University of Tokyo, 5Department ofChemistry and Biochemistry, University of California)

O-07

Catalysis driven by amyloid-substrate complex
Sawazaki Taka, Daisuke Sasaki, Youhei Sohma (Department of Medicinal Chemistry, School of
Pharmaceutical Sciences, Wakayama Medical University)

O-08

Intracellular assessment of droplet-driver protein by YK peptide fusion
Takayuki Miki1,2, Masahiro Hashimoto2, Hisakazu Mihara2 (1Graduate School of Engineering, The
University of Tokyo, 2School of Life Science and Technology, Tokyo Institute of Technology)

15:30–15:45

Break

15:45–16:45

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 10 (chairs: Yosuke Demizu, Jumpei Morimoto)

O-09

Light-induced modulation of self-assembly in azobenzene-conjugated short elastin-like peptides
Keitaro Suyama1, Iori Maeda2, Takeru Nose1,3 (1Faculty of Arts and Science, Kyushu University,2

Department of Physics and Information Technology, Kyushu Institute of Technology, 3Department ofChemistry, Faculty and Graduate School of Science, Kyushu University)
O-10

Development of a selection method to discover peptdies that bind to proteins using engineered split intein
Tsuyoshi Takahashi, Yutaro Watanabe (Graduate School of Science and Technology, Gunma University)

O-11

Extracellular-vesicle catch-and-release isolation system using a pH-dependent EV-binding curvaturesensing peptide
Kenichi Kawano1, Yuki Kuzuma1, Takahiro Fujiwara2, Fumiaki Yokoyama3, Katsumi Matsuzaki1(1Graduate School of Pharmaceutical Sciences, Kyoto University, 2Institute for Integrated Cell-Material
Sciences (WPI-iCeMS), Kyoto University, 3Graduate School of Science, The University of Tokyo)

O-12

Cardiolipin specific peptides designed to possess cell penetrating ability rescue mitochondrial
dysfunction

Gwangsu Shin1, Soonsil Hyun1, Dongwoo Kim1, Yoonhwa Choi1,2, Kyu Hong Kim3, Dongmin Kim2, Soie
Kwon4, Seung Hee Yang5, Kyeong-Ryoon Lee6, Jaehoon Yu1,2 (1Department of Chemistry & Education,
Seoul National University, 2CAMP Therapeutics Co., Ltd., 3Department of Biomedical Sciences, Seoul
National University Graduate School, 4Department of Internal Medicine, Seoul National University
Hospital, 5Kidney Research Institute, Seoul National University, 6Laboratory Animal Resource Center,
Korea Research Institute of Bioscience and Biotechnology)
16:50–18:20

Poster Presentations
Session 2 (2P-001–2P-055)
Odd numbers: 16:50–17:35
Even numbers: 17:35–18:20

19:00–21:00

Banquet (Biwako Hotel)

November 10 (Friday)
9:15–10:15

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 11 (chairs: Yuko Otani, Atsuhiko Taniguchi)

O-13

Enhancement of breast cancer migration in optimal serum concentration and application of functional
peptides for delivery of therapeutic molecules
Yurina Araki1, Masaya Hagiwara2, Daisuke Fujiwara1, Masataka Michigami1, Ikuo Fujii1, TomokaTakatani Nakase3,4, Ikuhiko Nakase1 (1Graduate School of Science, Osaka Metropolitan University,
2

RIKEN Hakubi Research Teams, 3College of Pharmacy, Mukogawa Women’s University, 4Institute for

Biosciences, Mukogawa Women’s University)
O-14

Design, synthesis and evaluation of dopa and catehollamine derivaties as an amyloid-beta aggreation
inhibitor
Fusheng Xu, Okada Miyu, Makabe Koki, Konno Hiroyuki (Department of Chemistry and Biochemical
Engineering, Graduate School of Science and Engineering, Yamagata University)

O-15

Habu snake three-finger toxins showed inhibitory activity against γ-secretase involved in amyloid β
production causing alzheimer disease
Tomohisa Ogawa, Rina Sakakibara, Masayoshi Seki, Masafumi Hidaka, Eugene Futa (Laboratory ofEnzymology, Graduate School of Agricultural Science, Tohoku University)

O-16

Machine learning complements human intuition in the discovery of catalytic peptides
Daniela Kalafatovic (Department of Biotechnology, University of Rijeka)

10:15–10:25

Break

10:25–11:10

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 12 (chairs: Tetsuya Kadonosono, Toshiki Sawada)

O-18

The design of cell-membrane permeable helix-loop-helix peptide that inhibits nuclear receptorcoactivator interaction
Daisuke Fujiwara1, Yuna Tanaka2, Shunsuke Inaura2, Sayoko Ito-Harashima3, Asako Yamaguchi1, IkuhikoNakase1, Ikuo Fujii1 (1Graduate School of Science, Osaka Metropolitan University, 2Graduate School of
Science, Osaka Prefecture University, 3Graduate School of Agriculture, Osaka Metropolitan University)

O-19

Soft computing for constructive peptide design and peptide activty prediction
Goran Mauša1,2, Marko Njirjak1, Erik Otović1 (1Faculty of Engineering, University of Rijeka, 2Center for
Artificial Intelligence and Cybersecurity, University of Rijeka)

O-20

Analysis of immunostimulatory mechanism through activation of dioxin receptor AHR by fermented
whey dericed from propionic acid bacteria
Yukihiko Narita1, Atsuko Miura1,2, Taku Sugawara2, Hiroaki Shimizu1, Hideaki Itoh3 (1Department of Brain
Surgery, Graduate School of Medicine, Akita University, 2Department of Spinal Surgery, Akita
Cerebrospinal and Cardiovascular Center, 3Department of Applied Chemistry, Graduate School of
Agricultural and Life Science, The University of Tokyo)

11:15–12:45

Poster Presentations
Session 3 (3P-001–3P-056)
Odd numbers: 11:15–12:00
Even numbers: 12:00–12:45

12:50–14:00

Lunch Break & Luncheon Seminar (12:55–13:55, Conference Room 305, Piazza Omi)

14:00–15:00

Japanese Peptide Society General Meeting

15:00–16:00

Oral Presentations (12 min talk, 2 min discussion, 1 min speaker exchange)
Session 13 (chairs: Ayami Matsushima, Takayuki Miki)

O-21

PPM1D phosphatase regulates neutrophil polarization through the alternative splicing of CEACAM3
Rui Kamada, Tatsuya Kodama, Shoma Kura, Fuki Kudoh, Kei Kawamura, Kazuyasu Sakaguchi(Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University)

O-22

An application of peptide microarrays for classifications of gastric cancer-risks based on a novel
biodetection principle
Yuki Tominaga1, Xiaoyan Wu2, Muxin Wei2,4, Kiyoshi Nokihara1,2,3 (1HiPep Laboratories, 2The First
Affiliated Hospital with Nanjing Medical University, 3The First School of Clinical Medicine, 4Institute ofIntegrated Medicine, Nanjing Medical University)

O-23

Construction of spiropyran-conjugated Tau-derived peptides for photocontrol of microtubule structures
Hiroshi Inaba1, Minamo Sakaguchi1, Soei Watari1, Akira Kakugo2, Kazunori Matsuura1 (1Graduate Schoolof Engineering, Tottori University, 2Graduate School of Science, Kyoto University)

O-24

Classification of water-soluble polymers based on diversified interactions of polymer-binding peptides
Toshiki Sawada, Shion Hasegawa, Takeshi Serizawa (Department of Chemical Science and Engineering,Tokyo Institute of Technology)

16:00–16:10

Break

16:10–16:50

Lectures of the Young Investigator Award(chair: Motoyoshi Nomizu)

Application of cell adhesive peptides to biomaterials
Yuji Yamada (Tokyo University of Pharmacy and Life Sciences)(chair: Takeru Nose)
Investigation of the molecular mechanism involved in the temperature-responsive self-assembly ofelastin-like peptide (FPGVG)n analogs and their application in molecular materials
Keitaro Suyama (Faculty of Arts and Science, Kyushu University)
16:50–17:35

Lecture of the Japanese Peptide Society Award(chair: Motoyoshi Nomizu)

Side reaction-inspired peptide and protein chemistry
Akira Otaka (Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences,
Tokushima University)
17:35–17:45

Closing Remarks (Youhei Sohma)