A holistic viewof biology,
with multiomics
Multiomics is a rapidly emerging approach thatincorporates multiple methods and data sets for
an integrated understanding of your samples.
Enabled by cutting-edge sequencing and array
technology, multiomic methods revolutionize
research and push the limits of novel scientificinsights to make new discoveries possible.

66%

What is multiomics?

of life science
research incorporates
multiomics1

A multidisciplinary approach that combines
two or more “-omics” for a multidimensionalview of human biology with limitless
applications.

Quantifies protein expression tounderstand cellular phonotypeand function. Mass spectrometry,mass cytometry, NGS-based
protein detection (CITE-Seq,PEA, Ab-Seq)

The study of how cells control
gene activity through processes
like DNA methylation and histone
modification. Methylationarrays, WGBS, ATAC-Seq,
CUT&Tag, ChIP-Seq, Hi-CProt

eom

Tran
sc

Epigicsr i p toenetGen

mics

ics

omics

The study of the transcriptome, thecomplete set of RNA transcriptsthat are produced by the genome,
and how they are altered during
the process of transcription andsplicing. mRNA-Seq, TotalRNA-Seq (including non-codingRNAs), cfRNA

Focuses on the structure,function, evolution, mapping, andediting of information codedwithin an organism’s DNA (thegenome). WGS, WES, targeted,genotyping arrays

What are the benefits of multiomics?
Enhanced discovery power: Next-generation sequencing
revolutionizes the types of discoveries possible.

Multiomics
publications haveincreased an average of63%

each year since 20122

Grants for
multiomics research
have increased by nearly50%

on average each year2

A More Holistic View
Gain a comprehensive picture of biologicalsystems with an integrated approach to research.
Deeper Understanding
Single-cell multiomic sequencing offers apowerful way to investigate individual cells fordiscovery at high resolution.
Maximizing Data
Make the most of precious research samples byextracting the maximum amount of data possible.
Novel Drug Discovery
Discover new therapeutic targets that enable thedevelopment of precision medicine.
A Customizable ApproachWith expert advisors and a range oftechnologies, our multiomics offerings provide
the versatility to pursue whichever “-omics” fit
your needs.

My advice is to dive right in. Multiomic workflows havebecome quite standard and just about anybody can dothis type of work. The field is moving so quickly, if you
wait for a time when it seems like it’s mature, it will
already have moved on to the next great thing.
– Ben Humphreys, MD, PhD

Chief of the Division of Nephrology, Washington University in St. LouisHow can multiomics be applied?
By providing insights into how the genome functions under different conditions,multiomics unlocks important discoveries that can help scientists optimize timeand research in multiple fields:CellularMolecular Biology
Deeper analysis at
the single-cell level
through multiomics gives
a more holistic pictureof biology that can help
reveal profound insightsthat inform morerobust research.

Cancer ResearchMultiomics is adding
to our ability to identify
novel drug targets,
improve current
therapies, and discovernovel biomarkers.
LEARN MORE

Genetic Diseases
ResearchMultiomics provides
biological context todisease-causing genetic
variants, allowing for the
discovery of novel
pathways, biomarkers,
and drug targets.3
LEARN MORE

LEARN MORE

More to see. More to understand.
More with multiomics.
Illumina is here to help you learn more about multiomics
and decide which approach best fits your research needs.
Learn more at www.illumina.com/more-with-multiomics1.

1. Cell Biologist Market Research. Percepta Associates, Inc. Accessed 2021, www.perceptaassociates.com.
2. Digital Science. Dimensions [Software] available from app.dimensions.ai. Accessed May 21, 2021, under license agreement.
3. Crowther, LM, Poms, M, Plecko, B. Multiomics tools for the diagnosis and treatment of rare neurological disease. Journal of Inherited Metabolic Disease,2018;4(3):425–434.