UICC 8th Edition Errata – 25th of May 2018
Corrections are in italics
Head and Neck Tumours
Page 19

Oral Cavity

Current
T2T3
T4aTumour 2 cm or less in greatest dimension and more than 5 mm but no more than 10 mm depth ofinvasion or,Tumour more than 2 cm but not more than 4 cm in greatest dimension and depth of invasion nomore than10 mm
Tumour more than 4 cm in greatest dimension or more than 10 mm depth of invasion(oral cavity) Tumour invades through the cortical bone of the mandible or maxilla or maxillarysinus, or invades the skin of the face.

Correct
T1
T2

T3

T4aTumour 2 cm or less in greatest dimension and 5 mm or less depth of invasion*
Tumour 2 cm or less in greatest dimension and more than 5 mm depth of invasion or,
Tumour more than 2 cm but not more than 4 cm in greatest dimension and depth of invasion nomore than 10 mm
Tumour more than 2 cm but not more than 4 cm in greatest dimension and depth ofinvasionmore than 10 mm or
Tumour more than 4 cm in greatest dimension and not more than 10 mm depth of invasion(oral cavity) Tumour more than 4 cm in greatest dimension and more than 10 mm depthof
invasionor tumour invades through the cortical bone of the mandible or maxilla or involves the maxillarysinus, or invades the skin of the face.

Pages 20, p27, p34, p38, p41, and p49
Currently
pN2a

Metastasis in a single ipsilateral lymph node, less than 3cm in greatest dimension withextranodal extension ormore than 3 cm but not more than 6 cm in greatest dimension without extranodal
extension

pN2aMetastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension withextranodal extension ormore than 3 cm but not more than 6 cm in greatest dimension without extranodal
extension

Correct

1

Page 24

Hypopharynx

Currently
T3
Tumour more than 4 cm in greatest dimension, or with fixation of hemilarynx orextension to oesophagus
Clarification
T3
Tumour more than 4 cm in greatest dimension, or with fixation of hemilarynx orextension to oesophageal mucosa

Page 28

Oropharynx – p16 positive
ClinicalCurrent Stage IIIT4Any

M0

Correct Stage IIIT4AnyN

M0

Pathological
Current Stage II

T1,T2

N2T3

Correct Stage II

T1,T2

N2
T3,T4

Page 40 and 41

M0
N0,N1

M0
M0

N0,N1

M0

Unknown primary

Current
N – Regional Lymph Nodes
N2c

Clarification
N2c

Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest
dimension, without extranodal extension

Delete contralateral
Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest
dimension, without extranodal extensionpN – Regional Lymph Nodes
pN2c

Clarification
pN2c

Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest
dimension, without extranodal extension

Delete contralateral
Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest
dimension, without extranodal extension
2Page 59

Oesophagus
Squamous cell
Pathological Stage

Current
Stage IVA

T4a
T4b
Any T

N2
AnyN
N3

M0
M0
M0

Stage IV

AnyT

AnyN

M1

Stage IVB

T4a
T4b
Any T
AnyT

N2
AnyN
N3
AnyN

M0
M0
M0
M1

Page 61

Oesophagus

Correct
Stage IVA

Adenocarcinoma
Pathological Prognostic GroupCurrent

Group IB

T1a
T1b

N0
N0

M0
M02,1, 2Group IIIA

T1
T2
T3,N2
N1
N0

M0
M0
M0

AnyAnyAny

Group IBT1aT1b

N0
N0

M0
M021, 2, X

Group IIIA

T1
T2
T3

N2
N1
N0

M0
M0
M0

Any
Any
Any

Correct

Page 66

DeleteStomachReference
Gastric Cancer 2016, in press
Clarification
Gastric Cancer 2017; 20: 217-225

3Page 72

Appendix

Current
Stage IVA

Any T

Any N0 M1a

Any T

Any N M1aCorrect
Stage IVA

Any T Any N M1bPage 80

G1LiverCurrent
T4

Tumor(s) involving a major branch of the portal or hepatic vein with direct invasion ofadjacent organs (including the diaphragm), other than the gallbladder or with perforation ofvisceral peritoneal.

Clarification
T4

Tumor(s) involving a major branch of the portal or hepatic vein or with direct invasion ofadjacent organs (including the diaphragm), other than the gallbladder or with perforation ofvisceral peritoneal.

Page 91/92

Ampulla of Vater

Current
T3

Tumor invades pancreas

Clarification
T3

Tumour invades pancreas or peripancreatic tissue

Current
N — Regional Lymph Nodes
NXN0N1
N2Regional lymph nodes cannot be assessed
No regional lymph node metastasis
Metastasis in 1 or 2 regional lymph nodes
Metastasis in 3 or more regional lymph nodes

Correct
N — Regional Lymph Nodes
NX
N0N1
N2Regional lymph nodes cannot be assessed
No regional lymph node metastasis
Metastasis in 1 to 3 regional lymph nodes
Metastasis in 4 or more regional lymph nodes

4Page 94

Pancreas

Current
T1Tumour 2 cm or less in greatest dimension
T1a Tumour 0.5 cm or less in greatest dimension
T1b Tumour greater than 0.5 cm and less than 1 cm in greatest dimension
T1c Tumor greater than 1 cm but no more than 2 cm in greatest dimension

Correct
T1

Tumour 2 cm or less in greatest dimension
T1a Tumour 0.5 cm or less in greatest dimension
T1b Tumour greater than 0.5 cm and no more than 1 cm in greatest dimension
T1c Tumor greater than 1 cm but no more than 2 cm in greatest dimension

Page 102

Pancreas

Current
T4

Tumour perforates visceral peritoneum (serosa) or invades other organs or adjacent structures

Correct
T4

Tumour invades adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels(coeliac axis or the superior mesenteric artery)

Page 113

Pleural Mesothelioma

Current
T1

Tumour involves ipsilateral parietal or visceral pleura only, with or without involvement of visceral,
mediastinal or diaphragmatic pleura.

Correct
T1

Tumour involves ipsilateral parietal or visceral pleura only, with or without involvement of visceral,
mediastinal or diaphragmatic pleura.

Page 124

Soft Tissue Sarcoma

Current
Histological Types of Tumour
The following histological types are not included:
Kaposi sarcoma
Dermatofibrosarcoma (protuberans)
Fibromatosis (desmoid tumour)
Sarcoma arising from the dura mater, brain, hollow viscera, or parenchymatous organs (with the exception ofbreast sarcomas).
Angiosarcoma, an aggressive sarcoma, is excluded because its natural history is not consistent with theclassification.

5

Clarification
Histological Types of Tumour
The following histological types are not included:
Kaposi sarcoma
Dermatofibrosarcoma (protuberans)
Fibromatosis (desmoid tumour)
Sarcoma arising from the dura mater or brain,
Angiosarcoma, an aggressive sarcoma, is excluded because its natural history is not consistent with theclassification.
NoteCystosarcoma phylloides is staged as a soft tissue sarcoma of the superficial trunk

Page 140

Carcinoma of the skin of the eyelid

Current
T3

Tumor > 20 mm, but more than 30 mm in greatest dimension

Clarification
T3

Tumor > 20 mm in greatest dimension but more than 30 mm

Page 143

Melanoma

Current
pTX
pT0
pTis

Primary tumour cannot be assessed*
No evidence of primary tumour
Melanoma in situ (Clark level I) (atypical melanocytic hyperplasia, severe melanocytic
dysplasia, not an invasive malignant lesion)

Note:*pTX includes shave biopsies and regressed melanomas.

Clarification
pTX
pT0
pTis
Note:

Primary tumour cannot be assessed*
No evidence of primary tumour or regressed melanomas
Melanoma in situ (Clark level I)*pTX includes shave biopsies and curettage that do not fully assess the thickness of the primary..

Current
pT1Tumour 1 mm or less in thickness
pT1a 0.8mm or less in thickness without ulceration
pT1b 0.8mm or less in thickness with ulceration ormore than 0.8mm but no more than 1mm in thickness, with or without ulceration

Correct
pT1Tumour 1 mm or less in thickness
6pT1apT1bless than 0.8mm in thickness without ulceration
less than 0.8mm in thickness with ulceration or0.8mm or more but no more than 1mm in thickness, with or without ulceration

AndStage IIIB

pT0

N1b, N1c

M0

Stage IIIC

pT0

N2b, N2c, N3b, N3c

M0Page 149

Merkel Cell Carcinoma of the skin

Current
Pathological Stage
Stage IIIB

Any T

N1b,N2,N3

M0

N1b,N2,N3

M0

Correct
Pathological Stage
Stage IIIBT1,T2, T3, T4

Page 156

BreastCurrent:
pN3a ‘Metastasis in 10 or more ipsilateral axillary lymph nodes (at least one larger than 2 mm) or metastasis
in infraclavicular lymph nodes’
Clarrification:
pN3a ‘Metastasis in 10 or more ipsilateral axillary lymph nodes (at least one larger than 2 mm) or metastasis
in infraclavicular lymph nodes/level III lymph nodes’.

Page 166

Cervix Uteri

Current
Regional Lymph Nodes
The regional lymph nodes are the paracervical, parametrial, hypogastric (internal iliac, obturator), commonand external iliac, presacral, and lateral sacral nodes. Para-aortic nodes are not regional.
Correct
Regional Lymph Nodes
The regional lymph nodes are the paracervical, parametrial, hypogastric (internal iliac, obturator), commonand external iliac, presacral, lateral sacral nodes and para-aortic nodes.
NotethIn the 7 edition the paraortic nodes were considered to be metastatic but to be consistent with advice fromFIGO the paraortic nodes are now classified as regional

7

Page 173/4

Uterus Endometrium

Current
Stage III
Stage IIIC1
Stage IIIC2

T1, T2, T3
T1, T2, T3
T1, T2, T3N1, N2 M0
N1N2M0
M0Correct
Stage IIIC
Stage IIIC1
Stage IIIC2

T1, T2, T3
T1, T2, T3
T1, T2, T3

N1, N2 M0
N1N2M0
M0Page 175
Current Uterine Sarcomas(leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma)(ICD-O-3 53, 54)
Clarrification(leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma)(ICD-O-3 53, 54, 54.1, 54.2)

P 179

Ovary

Current

Regional Lymph Nodes

The regional lymph nodes are the hypogastric (obturator), common iliac, external iliac, lateral sacral, paraaortic, retroperitoneal, and inguinal nodes.
Correct

Regional Lymph Nodes

The regional lymph nodes are the hypogastric (obturator), common iliac, external iliac, lateral sacral, paraaortic, and retroperitoneal nodes** Note*including intra-abdominal node such as greater omental nodes.
Page 182

Ovary

Current
M0
M1

No distant metastasis
Distant metastasis

Correct
M0
M1
M1aM1b

M – Distant Metastasis

M – Distant Metastasis

No distant metastasis
Distant metastasis
Pleural effusion with positive cytology
Parenchymal metastasis and metastasis to extra-abdominal organs (including inguinal lymph nodes
and lymph nodes outside the abdominal cavity)
8Current

Stage

Stage I
Stage IAStage IB
Stage ICStage II
Stage IIA
Stage IIB
Stage IIC

T1
T1a
T1b
T1c
T2
T2a
T2b
T2c

N0
N0
N0
N0
N0
N0
N0
N0

Correct

M0
M0
M0
M0
M0
M0
M0
M0

Stage

Stage I
Stage IAStage IB
Stage ICStage II
Stage IIA
Stage IIB
Stage IIC

T1
T1a
T1b
T1c
T2
T2a
T2b
T2c

N0
N0
N0
N0
N0
N0
N0
N0

Page 186
Current:

GTT

Pretreatment<10310 – < 10310 – < 10

M0
M0
M0M0M0M0M0M034

10 – < 1045>10 serum hCG (IU/ml)

34

10 – < 10545≥10 serum hCG(IU/ml)

Clarification
Pretreatment<10Page 188

Penis

5Current
T — Primary Tumour
Tis
Ta

Carcinoma in situ
1Noninvasive verrucous carcinoma

T1

Tumour invades subepithelial connective tissue
T1aTumour invades subepithelial connective tissue without lymphovascular invasion and is
not poorly differentiatedT1bTumour invades subepithelial connective tissue with lymphovascular invasion or is poorly
differentiated

Note:
Verrucous carcinoma not associated with destructive invasion.

19

Correct
Tis
TaCarcinoma in situ (Penile intraepithelial neoplasia – PeIN)
1
Noninvasive localized squamous cell carcinoma

T1Tumour invades subepithelial connective tissue
T1aTumour invades subepithelial connective tissue without lymphovascular invasion or
perineural invasion and is not poorly differentiatedT1bTumour invades subepithelial connective tissue with lymphovascular invasion or
perineural invasion or is poorly differentiated

2

Note:
Including verrucous carcinoma.

12

Glans:
Foreskin:
Shaft:
location

Tumor invades lamina propria
Tumor invades dermis, lamina propria or dartos fascia
Tumor invades connective tissue between epidermis and corpora and regardless ofPage 191, 193 Prostate
Current

T32Tumour extends through the prostatic capsule
T3a
Extracapsular extension (unilateral or bilateral) including microscopic bladder neckinvolvement

Clarification
T32Tumour extends through the prostatic capsule
T3a
Extraprostatic extension (unilateral or bilateral) including microscopic bladder neckinvolvement

Current
pTNM Pathological Classification
The pT and pN categories correspond to the T and N categories. For pM see page 8
However, there is no pT1 category because there is insufficient tissue to assess the highest pT categoryor sub-categories of pT2

ClarificationpTNM Pathological Classification
The pT and pN categories correspond to the T and N categories. For pM see page 8

However, there is no pT1 category because there is insufficient tissue to assess the highest pT
category. There are no sub-categories of pT2
Correct
Prognostic Factor Grid10

Gleason Sum ScorePage 195

TestesCurrent
Stage IIA
Stage IIBStage II

Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX

N1
N1
N2
N2
N3
N3

M0
M0
M0
M0
M0
M0

S0
S1
S0
S1
S0
S1

Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX
Any pT/TX

N1
N1
N2
N2
N3
N3

M0
M0
M0
M0
M0
M0

S0
S1
S0
S1
S0
S1

Correct
Stage IIA
Stage IIB
Stage IIC

Page 199

KidneyCurrent
T — Primary Tumour
T3Tumour extends into major veins or perinephric tissues but not into the ipsilateral adrenal glandand not beyond Gerota fascia
T3aTumour extends into the renal vein or its segmental (muscle containing) branches, ortumour invades perirenal and/or renal sinus fat (peripelvic) fat but not beyond Gerota
fasciaT3b
Tumour grossly extends into vena cava below diaphragmT3cTumour grossly extends into vena cava above the diaphragm or invades the wall of thevena cava

Clarification
T3Tumour extends into major veins or perinephric tissues but not into the ipsilateral adrenal glandand not beyond Gerota fascia
T3aTumour extends into the renal vein or its segmental (muscle containing) branches, or
tumour invades the pelvicalyceal system or tumour invades perirenal and/or renal sinus
fat (peripelvic) fat but not beyond Gerota fascia
T3bTumour grossly extends into vena cava below diaphragmT3cTumour grossly extends into vena cava above the diaphragm or invades the wall of thevena cava

Page 204, 205

Urinary Bladder

Current
T2

Tumour invades muscle
T2aTumour invades superficial muscle (inner half)11T2bTumour invades deep muscle (outer half)

Stage IVA

T4bN0M0

Correct
T2Tumour invades muscularis propria
T2aTumour invades superficial muscularis propria (inner half)
T2bTumour invades deep muscularis propria (outer half)

Stage IVA

Page 208

T4b

Any N M0

UrethraCurrent
Urothelial (Transitional cell) carcinoma of the prostate

Tis puTis pdCarcinoma in situ, involvement of prostatic urethra
Carcinoma in situ, involvement of prostatic ducts

Correct
Urothelial (Transitional cell) carcinoma of the prostate
Tis puCarcinoma in situ, involving the prostatic urethra, periurethral or prostatic ducts without stromalinvasion

Page 224

Malignant Melanoma of the Uvea

Correct
Stage*
Note*The stage groups are for malignant melanoma of the choroid and ciliary body but not of the iris
Page 232

Lacrimal GlandCurrent
T2

Tumour more than 2 cm but not more than 4 cm in greatest dimension,
limited to the lacrimal gland
T2a
No periosteal or bone involvement
T2b
Periosteal involvement without bone involvement
T2c
Bone involvement

Clarification
T2

Tumour more than 2 cm but not more than 4 cm in greatest dimension,
limited to the lacrimal gland
T2a
No periosteal or bone involvement
T2b
Periosteal involvement without bone involvement
T2c
Bone involvement12