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Publications 2004~2020- - - - - - - - - - 2020 年 - - - - - - - - - - 實吉尚郎、小野晶
プロオリゴ型核酸医薬を志向した保護基の開発研究
有機合成化学協会誌、2020, 78 (9), 886-893.（総説）
https://doi.org/10.5059/yukigoseikyokaishi.78.886
Tatsuya Funai, Chizuko Tagawa, Osamu Nakagawa, Shun-ichi Wada, Akira Ono and
Hidehito Urata
Enzymatic formation of consecutive thymine-HgII-thymine base pairs by DNA polymerases
Chem. Commun., 2020, 56, 12025-12028
DOI: 10.1039/d0cc04423g
https://doi.org/10.1039/D0CC04423G
Ryo Yamada, Issei Nomura, Yuki Yamaguchi, Yosuke Matsuda, Yoshikazu Hattori, Hirokazu
Tada, Akira Ono, Yoshiyuki Tanaka
Electrical conductance measurement of HgII-mediated DNA duplex in buffered aqueous
solution
Nucleosides, Nucleotides, & Nucleic Acids, 2020, 39 (8), 1083-1087.
https://doi.org/10.1080/15257770.2020.1755044(2020 Apr 28.)
Hisao Saneyoshi, Kodai Nakamura, Kazuma
Terasawa, Akira Ono
Development of Bioreduction Labile Protecting
Groups for the 2’-Hydroxyl Group of RNA
Organic Letters, 2020, 22, 15, 6006–6009.
https://doi.org/10.1021/acs.orglett.0c02086(Publication Date: July 14, 2020)

Hisao Saneyoshi, Yuta Yamamoto, Takayuki Ohta, Shoji Akai, Akira Ono
Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeledoligonucleotide for monitoring cellular uptake
Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127222.
https://doi.org/10.1016/j.bmc
l.2020.127222(Volume 30, Issue 13, 1 July

2020, 127222)

Tatsuya Funai, Megumi Aotani, Risa Kiriu, Junko Nakamura, Yuki Miyazaki, Dr. Osamu
Nakagawa, Dr. Shun-ichi Wada, Prof. Dr. Hidetaka Torigoe, Prof. Dr. Akira Ono and Prof. Dr.
Hidehito Urata“Silver(I) ion-mediated cytosine-containing base pairs: Metal ion specificity for duplex
stabilization and susceptibility toward DNA polymerases”
ChemBioChem, 2020, 21 (4), 517-522
https://doi.org/10.1002/cbic.201900450 (First published: 28 August 2019)- - - - - - - - - - 2019 年 - - - - - - - - - - Very Important Paper に選ばれました。
Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto,
Koudai Nakamura, Hisao Saneyoshi, Jiro Kondo“Novel DNA helical wire containing Hg(II) mediated T:T
and T:G pairs” (Very Important Paper)
Angew. Chem. Int. Ed., 2019, 58, 16835-16838.
Angew. Chem. 2019, 131, 16991 –16994.
https://doi.org/10.1002/anie.201910029

Akira Ono, Takahiro Atsugi, Misato Goto, Hisao Saneyoshi, Takahito Tomori, Kohji Seio,
Takenori Dairaku and Jiro Kondo“Crystal structure of a DNA duplex crosslinkedby
6-thioguanine–6-thioguanine
disulfides:
reversible
formationandcleavage catalyzed by Cu(II) ions andglutathione”
RSC Adv., 2019, 9, 22859–22862
https://doi.org/10.1039/C9RA03515J

Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, T. Saneyoshi, Akira Ono“Design, synthesis and cellular uptake of oligonucleotides modified with glutathione-labile
protecting groups”
Org. Lett., 2019, 21, 862−866.
https://doi.org/10.1021/acs.orglett.8b03501

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Xiwen Xing,
Yihong Feng,
Zutao Yu, Kumi Hidaka, Fenyong Liu, Akira Ono, Hiroshi Sugiyama,* and Masayuki Endo
“Direct Observation of the Double-Stranded DNA Formation through Metal Ion-MediatedBase Pairing in the Nanoscale Structure”
Chem. Eur. J., 2019, 25, 1446-1450.
https://doi.org/10.1002/chem.201805394- - - - - - - - - - 2018 年 - - - - - - - - - - Hisao Saneyoshi & Akira Ono“Development of Protecting Groups for Prodrug-Type Oligonucleotide Medicines”
Chem. Pharm. Bull., 2018, 66, 147-154.
https://doi.org/10.1248/cpb.c17-00696- - - - - - - - - - 2017 年 - - - - - - - - - - - Akira Ono, Toru Sugawara, Hisao Saneyoshi, Jiro Kondo,“Crystal structure of a DNA duplex containing four Ag(I) ions inconsecutive dinuclear Ag(I)-mediated base pairs:
4-thiothymine−2Ag(I)−4-thiothymine”
Chem. Comm., 2017, 53, 11747 - 11750. (Cover)
DOI:10.1039/C7CC06153F
https://doi.org/10.1039/C7CC0615
3F
カバーに選ばれました

Jiro Kondo*, Yoshinari Tada, Takenori Dairaku, Yoshikazu Hattori, Hisao Saneyoshi,
Akira Ono, Yoshiyuki Tanaka,"A metallo-DNA nanowire with uninterrupted one-dimensional silver array"
Nature Chemistry, 2017, 9(10), 956-960. doi:10.1038/nchem.2808.
https://www.nature.com/articles/nchem.2808

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Hisao Saneyoshi, Kazuhiko Kondo, Koichi Iketani, Akira Ono“Alkyne-linked reduction-activated protecting groups for diverse functionalization on the
backbone of oligonucleotides”
Bioorg. Med. Chem., 2017, 25, 3350-3356..
https://doi.org/10.1016/j.bmc.2017.04.020
Hisao Saneyoshi, Yuta Yamamoto, Kazuhiko Kondo, Yuki Hiyoshi, Akira Ono"Conjugatable/Bioreduction
Cleavable
Linkerforthe5′-Functionalization
Oligonucleotides"
J. Org. Chem., 2017, 82, 1796-1802
DOI:10.1021/acs.joc.6b02527
https://doi.org/10.1021/acs.joc.6b02527

of- - - - - - - - - - 2016 年 - - - - - - - - - - - Hisao Saneyoshi,,Koichi Iketani, Kazuhiko Kondo, Takeo Saneyoshi, Itaru Okamoto, andAkira Ono
“Synthesis and Characterization of Cell-Permeable Oligonucleotides Bearing ReductionActivated Protecting Groups on the Internucleotide Linkages”
Bioconjugate Chem., 2016, 27, 2149–2156.
DOI:10.1021/acs.bioconjchem.6b00368
https://doi.org/10.1021/acs.bioconjchem.6b00368

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Takenori Dairaku,* Kyoko Furuita, Hajime Sato, Jakub Šebera, Katsuyuki Nakashima, Jiro
Kondo, Daichi Yamanaka, Yoshinori Kondo, Itaru Okamoto, Akira Ono, Vladimír
Sychrovský,* Chojiro Kojima,* and Yoshiyuki Tanaka*“Structure Determination of an AgI-Mediated Cytosine–Cytosine Base Pair within DNA
Duplex in Solution with 1H/15N/109Ag NMR Spectroscopy”
Chem. Eur. J. 2016, 22, 13028-13031.
DOI: 10.1002/chem.201603048
https://doi.org/10.1002/chem.201603048

Takenori Dairaku, Kyoko Furuita, Hajime Sato, Jakub Šebera, Katsuyuki Nakashima, Akira
Ono, Vladimír Sychrovský, Chojiro Kojima, and Yoshiyuki Tanaka,*“HgII/AgI-mediated base pairs and their NMR spectroscopic studies”
Inorg. Chim. Acta, 2016, 452, 34-42.
(DOI: 10.1016/j.ica.2016.03.018)
https://doi.org/10.1016/j.ica.2016.03.018
Hisao Saneyoshi*, Kazuhiko Kondo, Naoki Sagawa, Akira Ono*
“Glutathione-triggered activation of the model of pro-oligonucleotide with benzyl protecting

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groups at the internucleotide linkage”
Bioorg. Med. Chem. Lett., 2016, 26, 622-625.
doi:10.1016/j.bmcl.2015.11.064
https://doi.org/10.1016/j.bmcl.2015.11.064
Jakub Šebera, Yoshiyuki Tanaka, Akira Ono, Vladimír Sychrovský
“The effect of chemical modification of DNA base on binding of Hg-II and Ag-I in metalmediated base pairs”
Inorganic Chimica Acta, 2016, 452, 199-204.
https://doi.org/10.1016/j.ica.2016.03.007

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- - - - - - - - - - 2015 年 - - - - - - - - - - - Tatsuo Kurokawa,* Manabu Igawa, Akira Ono, and Itaru Okamoto*“Selective Transport of Mercury(II) Ions across Supported Liquid Membrane with Thymine
Derivative as Carrier”
Chem. Lett., 2015, 44, 1732–1734.
doi:10.1246/cl.150769 https://doi.org/10.1246/cl.150769

Takenori Dairaku, Kyoko Furuita, Hajime Sato, Yoshinori Kondo, Chojiro Kojima, Akira Ono& Yoshiyuki Tanaka*“Exploring a DNA Sequence for the Three-Dimensional Structure Determination of a
Silver(I)-Mediated C-C Base Pair in a DNA Duplex By 1H NMR Spectroscopy”
Nucleosides Nucleotides Nucleic Acids. 2015, 34 (12), 877-900.
DOI:10.1080/15257770.2015.1088160
https://doi.org/10.1080/15257770.2015.1088160
Hisao Saneyoshi,* Yuki Hiyoshi, Koichi Iketani, Kazuhiko Kondo, Akira Ono*
“Bioreductive deprotection of protected thymine bases in oligonucleotides for the activationof duplex formation”
Bioorg. Med. Chem. Lett., 2015, 25, 5632-5635.
https://doi.org/10.1016/j.bmcl.2015.10.025
Yoshiyuki Tanaka,* Jiro Kondo, Vladimír Sychrovský, Jakub Šebera, Takenori Dairaku,
Hisao Saneyoshi, Hidehito Urata, Hidetaka Torigoe and Akira Ono*
“Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and othermetallo-base-pairs”
Chem. Comm., 2015, 51(98), 17343-17360. “Feature Article”
DOI: 10.1039/C5CC02693H
https://doi.org/10.1039/C5CC02693H

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Jiro Kondo*, Yoshinari Tada, Takenori Dairaku, Hisao Saneyoshi, Itaru Okamoto, Yoshiyuki
Tanaka,Akira Ono
“High-resolution crystal structure of AgI-RNA hybrid duplex containing Watson-Crick-like
C−AgI−C metallo-base pairs”
Angew. Chem. Int. Ed., 2015, 54, Issue 45, 13323–13326.
(10.1002/anie.201507894)
https://doi.org/10.1002/ange.201507894

Takenori Dairaku, Kyoko Furuita, Hajime Sato, Jakub Šebera, Daichi Yamanaka, Hiroyuki
Otaki, Shoko Kikkawa, Yoshinori Kondo, Ritsuko Katahira, F. Matthias Bickelhaupt, Célia
Fonseca Guerra, Akira Ono, Vladimír Sychrovský, Chojiro Kojima, and Yoshiyuki Tanaka“Direct detection of the mercury–nitrogen bond in the thymine–HgII–thymine base-pair with
199Hg NMR spectroscopy”
Chem. Comm., 2015, 51, 8488-8491.
DOI: 10.1039/C5CC02423D
https://doi.org/10.1039/C5CC02423D

Hisao Saneyoshi,* Kanami Shimamura, Naoki Sagawa, Yuki Ando, Takahito Tomori, Itaru
Okamoto, Akira Ono*
“Development of a photolabile protecting group for phosphodiesters in oligonucleotides”
Bioorg. Med. Chem. Lett., 2015, 25, 2129-2132.
https://doi.org/10.1016/j.bmcl.2015.03.064

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- - - - - - - - - - 2014 年 - - - - - - - - - - - Mituhiro Kuriyama, Kaichiro Haruta, Takenori Dairaku, Takuya Kawamura, Shoko Kikkawa,
Kiyofumi Inamoto, Hirokazu Tsukamoto, Yoshinori Kondo, HidetakaTorigoe, Itaru Okamoto,
Akira Ono, Eugene Hayato Morita,Yoshiyuki Tanaka“Hg2+-Trapping Beads: Hg2+-Specific Recognition through Thymine–Hg(II)–Thymine Base
Pairing”
Chem. Pharm. Bull., 2014, 62, 709–712.
https://doi.org/10.1248/cpb.c13-00918
Tatsuya Funai, Junko Nakamura, Yuki Miyazaki, Risa Kiriu, Osamu Nakagawa, Shunichi
Wada, Akira Ono, and Hidehito Urata*“Regulated Incorporation of Two Different Metal Ions into Programmed Sites in a Duplex by
DNA Polymerase Catalyzed Primer Extension” Angew. Chem. Int. Ed., 2014, 53, 66246627.
DOI: 10.1002/anie.201311235
https://doi.org/10.1002/anie.201311235
J. Kondo, T. Yamada, C. Hirose, I. Okamoto, Y. Tanaka, A. Ono,
“Crystal structure of metallo-DNA duplex containing consecutive Watson-Crick-like
T-Hg(II)-T base pairs”
Angew. Chem. Int. Ed., 2014, 53, 2385-2388.
https://doi.org/10.1002/anie.201309066
International Ed., DOI: 10.1002/anie.201309066
10.1002/ange.201309066
https://doi.org/10.1002/anie.201309066

H. Yamaguchi, J. Šebera, J. Kondo, S. Oda, T. Komuro, T. Kawamura, T. Dairaku, Y. Kondo,
I. Okamoto, A. Ono, J. V. Burda, C. Kojima, V. Sychrovský and Y. Tanaka,“The structure of metallo-DNA with consecutive thymine–HgII–thymine base pairs explains
positive entropy for the metallo base pair formation”
Nucleic Acids Research, 2014, 42, 4094-4099.
doi:10.1093/nar/gkt1344 https://doi.org/10.1093/nar/gkt1344

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- - - - - - - - - - 2013 年 - - - - - - - - - - - Jakub Šebera, Jaroslav Burda, Michal Straka, Akira Ono,Chojiro Kojima, Yoshiyuki Tanaka,
and Vladimír Sychrovský*“Formation of a Thymine-HgII-Thymine Metal-Mediated DNA Base Pair: Proposal andTheoretical Calculation of the Reaction Pathway” Chem. Eur. J., 2013, 19, 9884 – 9894.
10.1002/chem.201300460- - - - - - - - - - 2012 年 - - - - - - - - - - - Itaru Okamoto*, Takashi Ono, Rimi Sameshima and Akira Ono*
“Metal ion-binding properties of DNA duplexes containing thiopyrimidine base pairs”
Chem. Commun., (2012) 48, 4347-4349. https://doi.org/10.1039/C2CC15436F

Tomomi Uchiyama#, Takashi Miura#, Hideo Takeuchi, Takenori Dairaku, Tomoyuki Komuro,
Takuya Kawamura, Yoshinori Kondo, Ladislav Benda, Vladimir Sychrovsky*, Petr Bour,
Itaru Okamoto*, Akira Ono and Yoshiyuki Tanaka*,“Raman spectroscopic detection of the T-HgII-T base pair and the ionic characteristics ofmercury”
Nucleic Acids Research, (2012), 40, 5766-5774. https://doi.org/10.1093/nar/gks208
Tatsuya Funai, Yuki Miyazaki, Megumi Aotani, Eriko Yamaguchi, Osamu Nakagawa,Shunichi, Wada, Hidetaka Torigoe, Akira Ono, and Hidehito Urata*“AgI Ion Mediated Formation of a C–A Mispair by DNA Polymerases”
Angew. Chem. Int. Ed., (2012), 51, 6464 –6466. https://doi.org/10.1002/anie.201109191
Hidetaka Torigoe,* Itaru Okamoto, Takenori Dairaku, Yoshiyuki Tanaka, Akira Ono, T.
Kozasa,“Thermodynamic and structural properties of the specific binding between Ag+ ion and C:C
mismatched base pair in duplex DNA to form C-Ag-C metal-mediated base pair”
Biochimie, (2012) , 94, 2431-2440. https://doi.org/10.1016/j.biochi.2012.06.024
Hidetaka Torigoe, Yukako Miyakawa, Akira Ono, Tetsuo Kozasa“Positive cooperativity of the specific binding between Hg2+ ion and T:T mismatched basepairs in duplex DNA”
Thermochimica Acta (2012) 532, 28– 35. https://doi.org/10.1016/j.tca.2011.03.018

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- - - - - - - - - - 2011 年 - - - - - - - - - - - A. Ono, H. Torigoe, Y. Tanaka, I. Okamoto“Binding of metal ions by pyrimidine base pairs in DNA duplexes” Chem. Soc. Rev., (2011)
40, 5855-5866.
https://doi.org/10.1039/C1CS15149E

T. Ono, K. Yoshida, Y. Saotome, R. Sakabe, I. Okamoto, A. Ono*
“Synthesis of covalently linked parallel and antiparallel DNA duplexes containing the metalmediated base pairs T-Hg(II)-T and C-Ag(I)-C” Chem. Comm., (2011), 47 (5), 1542-1544.
https://doi.org/10.1039/C0CC02028A

Torigoe, H., Miyakawa, Y., Ono, A., and Kozasa, T.
"Thermodynamic Properties of the Specific Binding between Ag+ Ions and C:C Mismatched
Base Pairs in Duplex DNA"
Nucleosides, Nucleotides, & Nucleic Acids, 30(2), 149-167 (2011). doi:
10.1080/15257770.2011.553210
Torigoe, H., Ono, A., and Kozasa, T.
"Detection of Single Nucleotide Polymorphisms by the Specific Interaction between
Transition Metal Ions and Mismatched Base Pairs in Duplex DNA"
Transition Metal Chemistry, 36(2), 121-144 (2011). DOI: 10.1007/s11243-010-9445-z

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- - - - - - - - - - 2010 年度 - - - - - - - - - - - Hidetaka Torigoe, Akira Ono, and Tetsuo Kozasa“Hg(II) Ion Specifically Binds with T:T Mismatched Base Pair in Duplex DNA”
Chem. Eur. J., 2010, 16, 13218-13225. https://doi.org/10.1002/chem.201001171- - - - - - - - - - 2009 年度 - - - - - - - - - - - Itaru Okamoto, Kenji Iwamoto, Yuko Watanabe, Yoko Miyake, Akira Ono“Switching Metal Ion Binding Selectivity of Chemically Modified Uracil Pairs in DNA
Duplexes Triggered by pH Change”
Angew. Chem. Int. Ed., 2009, 48, 1648-1651.
https://doi.org/10.1002/anie.200804952

Yoshiyuki Tanaka* and Akira Ono*, Structural Studies on MercuryII-mediated T-T Base-pairwith NMR Spectroscopy (Chapter 16), In Nick Hadjiliadis and Einar Sletten Eds.,"Metal Complexes - DNA Interactions",
John Wiley & Sons, West Sussex, UK (2009). ISBN: 978-1-4051-7629-3（英文著書）- - - - - - - - - - 2008 年度 - - - - - - - - - - - Akira Ono*, Shiqi Cao, Humika Togashi, Mitsuru Tashiro, Takashi Fujimoto, Tomoya
Machinami, Shuji Oda, Yoko Miyake, Itaru Okamoto, and Yoshiyuki Tanaka“Specific interactions between Silver(I) Ions and Cytosine–Cytosine Pairs in DNA Duplexes”
Chem. Comm., (2008), 4825-4827. (22 Aug 2008)https://doi.org/10.1039/B808686A

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Yoshiyuki Tanaka* and Akira Ono*
“Nitrogen-15 NMR spectroscopy of N-metallated nucleic acids: insights into 15N NMR
parameters and N–metal bonds”
Dalton Trans., (2008), issue 37, 4965–4974. https://doi.org/10.1039/B803510P

田中好幸、鳥越秀峯、小野 晶「新規ナノデバイス材料としてのメタロ DNA 分子の構造」
生物物理、48（2）、119-124 （2008）https://doi.org/10.2142/biophys.48.119- - - - - - - - - - 2007 年度 - - - - - - - - - - - Yoshiyuki Tanaka*, Shuji Oda, Hiroshi
Yamaguchi, Yoshinori Kondo, Chojiro Kojima
and Akira Ono*
“15N-15N J-coupling across HgII: Direct
observation of HgII-mediated T-T base pairs
in a DNA duplex”, J. Am. Chem. Soc., 2007,
129, 244-245.
https://doi.org/10.1021/ja065552h- - - - - - - - - - 2006 年度 - - - - - - - - - - - Yoko Miyake, Humika Togashi, Mitsuru Tashiro, Hiroshi Yamaguchi, Shuji Oda, Megumi
Kudo, Yoshiyuki Tanaka, Yoshinori Kondo, Ryuichi Sawa, Takashi Fujimoto, Tomoya
Machinami, Akira Ono“MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes”
J. Am. Chem. Soc., 2006, 128, 2172-2173.
DOI: 10.1021/ja056354d
https://doi.org/10.1021/ja056354d

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Irie, D., Ono, A. & Izuta, S.
“Recognition of Oxidized Thymine Base on the Single-Stranded DNA by Replication Protein
A” Nucleosides Nucleotides & Nucleic Acids, 25, 436-451 (2006).
https://doi.org/10.1080/01457630600684138
Yoshiyuki Tanaka, Hiroshi Yamaguchi, Shuji Oda, Makoto Nomura, Chojiro Kojima,
Yoshinori Kondo, Akira Ono“NMR spectroscopic study of a DNA duplex with mercury-mediated T-T base pairs”
Nucleoside Nucleotides & Nucleic Acids, 25, 613-624 (2006).
https://doi.org/10.1080/15257770600686154
Akira Ono
“DNA-synthetic polymer conjugates” Macromol. Chem. Phys., 207, 1629-1632 (2006).
https://doi.org/10.1002/macp.200600370
Torigoe, H. and Ono, A.
"Novel Strategy for Efficient Detection of Single Nucleotide Polymorphism (SNP):SpecificBinding of Mercury (II) Cation to T:T Mismatch Base Pair and That of Silver (I) Cation to
C:C Mismatch Base Pair" in "Moleculomics and Thereafter" edited by Takaki Hiwasa,
Research Signpost, Ltd., pp.1-21 (2006).

- - - - - - - - - - - - 2005 年度 - - - - - - - - - - - Yoko Miyake and Akira Ono.
“Fluorescent Sensor for Redox-Environment: A Redox-Controlled Molecular Device Basedon the Reversible Mercury Mediated Folded Structure Formation of Oligothymidylate”
Tetrahedron Lett., 46, 2441-2443 (2005). https://doi.org/10.1016/j.tetlet.2005.02.049

小野 晶「DNA 高次構造を利用した機能性分子開発：金属含有 DNA ワイヤー」
化学と工業、58-4、469-472,（2005）(10015599659)

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- - - - - - - - - - - - 2004 年度 - - - - - - - - - - - Akira Ono and Humika Togashi.
“Novel Highly Selective Mercury Sensing in Aqueous Solutions: Fluorescence Resonance
Energy Transfer associated with Hairpin Structure Formation of Oligonucleotide Derivatives
derived by Mercury-Mediated Thymine-Hg-Thymine Pair Formation”
Angew. Chem. Int. Ed., 43, 4300-4302 (2004) https://doi.org/10.1002/anie.200454172

Mio Kubota, Akira Ono.
“DNA-Based Aromatic Zipper Fastened by an Aromatic Stacking Interaction”
Tetrahedron Lett., 45, 5755-5758, (2004).
https://doi.org/10.1016/j.tetlet.2004.05.032

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Momo Kosuge, Mio Kubota, Akira Ono“Multiple-pyrene residues arrayed along DNA backbone exhibit significant excimer
fluorescence”
Tetrahedron Lett., 45, 3945-3947, (2004)
https://doi.org/10.1016/j.tetlet.2004.03.074

Mio Kubota, Akira Ono“Stabilization of DNA Triplexes by Dangling Aromatic Residues”
Tetrahedron Lett., 45, 1187-1190, (2004).
https://doi.org/10.1016/j.tetlet.2003.11.144

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