Symposium Arrangements
1. Registration
Registration is open after 3 p.m. on August 3rd and throughout the meeting at theentrance to the Okazaki Conference center (OCC).
2. Infromation for oral presentation
Presentation time including discussion for each speaker is 30 min (5 speakers/session) or
25 min (6 speakers/session). Generally, presentations should be given with speaker's
own laptop computer. All presenters in a session should set up and test the connection to
the projector before the session begins.
3. Information for poster presentation
Please post your materials on the board indicating the correct poster number throughout
the symposium. Size of the poster should not exceed 115 cm x 85 cm (hight x width).
The core time of poster presentation is scheduled for the 5th (10:45-12:00).
4. Get-together party
On August 3rd at 17:30-19:00 at OCC (room B). A jazz performance starts at 18:00. This
party is free for the perticipants who paid full registration fee and her/his accompanied
person.
5. Lunch service
Lunch will be served for all participants at OCC.
6. Group photo
After the PAT-CVR Lectures on Wednesday, Aug. 5th. Please gather at the entrance of
OCC.
7. Reception and Shamisen Concert
The reception will be held on Tuesday, August 4th at 19:10-20:10 at OCC (room B).
After the reception, the Shamisen concert will be held at Room A. Note that drinking andeating are prohibited in room A.
8. Excursion & Free Discussion & Barbeque with Wadaiko Concert (5,000 yen/person,
90 persons at maximum). Departure of tour bus: Aug. 5th, 13:00 at the Entrance of OCC.
9. Dinner with brief Koto Concert (Shabu-shabu dinner, 5000 yen/person, 100 persons at
maximum). Departure of shuttle bus: Aug. 6th, 19:05 at the Entrance of OCC.
10. Shuttle Bus Service
The Okazaki New Grand Hotel provides daily complimentary shuttle bus service
between Higashi Okazaki Station (south exit (★ on the map)) and the hotel every 15
minutes from 17:00 to 20:00 (the last bus departs at 20:00).
Arranged shuttle bus for PAT-CVR participants(1) From Higashi Okazaki Station (south exit) to Okazaki New Grand Hotel
Departure time
August 3rd: 15:30 / 16:30 / 17:30(2) From Okazaki New Grand Hotel to Okazaki Conference Center (OCC)
Departure time
August 3rd: 15:00 / 16:00 / 17:00
August 4th, 5th and 6th: 7:50 am / 8:10 am / 8:30 am2

Okazaki Map

Okazaki Conference Center (OCC)3

4

Program
August 3rd, Modnay
15:00-17:30

Registration

17:30-19:00

Get-Together with Jazz Concert (OCC Room B)

August 4th, Tuesday
Opening Remarks (Room A)
08:40-08:50

Yasunobu Okada

Director-General, NIPS, Japan

PAT−CVR Lectures (Room A)
08:50-09:20

Chairperson: Else K Hoffmann

Yasunobu Okada, Takahiro Shimizu, Elbert L. Lee, Hana Inoue, Hiromi Uramoto, Kaori
Sato & Tomohiro Numata (NIPS, Japan)
Roles of anion channels and disordered cell volume regulation in apoptotic andnecrotic cell death

09:20-09:50

Chairperson: Junichi Nabekura

Kai Kaila (Univ. Helsinki, Finland)
Neuronal chloride regulation and epilepsy

PAT Symposium (Room A)
PAT−I
CFTR: From Molecular Structure to Tissue Physiology and Therapy for CF
Chaired by David N. Sheppard and Yoshiro Soma
10:00-10:30

Ruth Muchekehu, Ning Yang, Mary Abigail S. Garcia1 & Paul M. Quinton(University of California, USA)
Does Mucus need HCO3− ?

10:30-11:00

Stan Pasyk, Leigh Wellhauser, Patrick Kim Chiaw, Canhui Li, Mohabir Ramjeesingh& Christine E. Bear (SickKids Hospital, CANADA)
Biochemical studies of the enzymatic activity of full length CFTR and catalytic
site mutants

11:00-11:30

Jeng-Haur Chen, Zhiwei Cai & David N. Sheppard (University of Bristol, UK)

Direct sensing of intracellular pH by the CFTR Cl− channel

11:30-12:00

Hsiao Chang Chan (The Chinese University of Hong Kong, Hong Kong)
Involvement of CFTR in oviductal bicarbonate transport and embryo
development5

12:00-12:30

Haouaria Balghi, Alexandra Evagelidis, David Y. Thomas & John W. Hanrahan(McGill Univ., Canada)
Enhanced calcium entry in cells that express ∆F508 CFTR: crosstalk between
mature CFTR, ORAI1, and the ER-resident protein STIM1

12:30-13:30

Poster & Lunch

PAT−II
CLC Chloride Channel
Chaired by Shinichi Uchida and Thomas Jentsch
13:30-13:55

Christoph Fahlke (Institut für Neurophysiologie, Medizinische Hochschule Hannover,Germany)
Function of renal ClC channels and regulation by the accessory subunit barttin

13:55-14:20

Thomas J. Jentsch (FMP and MDC, Germany)
ClCK/barttin Cl channels – role in the kidney and the inner ear

14:20-14:45

María Isabel Niemeyer, L. Pablo Cid, Yamil R. Yusef, Rodolfo Briones & Francisco V.
Sepúlveda (CECS and CIN, Chile)
Titration of specific residues account for complex gating of a ClC chloride
channel by extracellular protons

14:45-15:10

Alessandra Picollo, Mattia Malvezzi, Jon Houtman & Alessio Accardi (University of
Iowa, USA)
Anion binding and selectivity in the CLC family of channels and transporters

15:10-15:35

S. Uchida, N. Nomura, N. Sugawara, T. Morimoto, Y. Kondo, S. Naito, N. Yui, K Oi,
G. Talat, K.M.Z. Hossain, M. Wakabayashi, H. Nishida, E. Ohta, A. Ohta, E. Sohara, T.
Rai, S. Sasaki (Tokyo Medical and Dental University, Japan)

Molecular pathogenesis of Bartter syndrome caused by R8L barttin mutation

15:35-16:00

Jorge E. Sanchez-Rodriguez, Jose A. de Santiago-Castillo & Jorge Arreola (Universityof San Luis Potosi, Mexico)

Proton and Chloride Ions Alter ClC-2 Gating by Interfering with Closing ofProtopore Gate

16:00-16:30

Coffee BreakPAT−III
Ligand-gated Anion Channel
Chaired by Junichi Nabekura and Atsuo Fukuda
16:30-17:00

Andrew J Moorhouse, Jane E. Carland, Michelle A. Cooper, Silas Sugiharto, Trevor
M. Lewis, Peter H. Barry, John A. Peters, Jeremy J. Lambert (The University of New
South Wales, Australia)
Molecular Determinants and Biophysical Mechanisms of Anion Selectivity in
Glycine Receptor-Channels

6

17:00-17:30

H.J. Luhmann, W. Kilb, I.L. Hanganu-Opatz, A. Okabe, B.A. Sava, C. Shimizu-Okabe& A. Fukuda (Johannes Gutenberg University, Germany)
Function of ligand-gated chloride channels in the newborn rodent cerebral
cortex17:30-18:00

Claudio Rivera (University of Helsinki, Helsinki, Finland)
Mechanisms of KCC2 gene regulation in immature neurons

18:00-18:30

Rustem Khazipov, Marat Minlebaev & Yehezkel Ben-Ari (INMED-INSERM U901,
France)Actions of GABA on the immature cortical neurons in vitro and in vivo

18:30-19:00

A. Fukuda, T. Furukawa, T. Morishima & T. Kumada (Hamamatsu University Schoolof Medicine, Japan)
Endogenous taurine tonically activates GABAA receptors in embryonic mouseneocortex

CVR Symposium (Room C)
CVR−I
CVR & Anion Channel/Transporter
Chaired by Andrés Stutzin and Hideki Sakai
10:00-10:30

Clive M. Baumgarten, Wu Deng & Frank J. Raucci Jr. (Virginia Commonwealth
University, USA)
Reactive oxygen species produced by NADPH oxidase and mitochondria
regulate volume-sensitive Cl– channels: A common theme for multiple pathways

10:30-11:00

Dazhi Xiong, Nathanael S. Heyman, Judith Airey, Linda Ye, Cherie A. Singer, Shanti
Rawat, Mi Zhang, Rebecca Evans, Dean J. Burkin, Fiona C. Britton, Dayue Duan &Joseph R. Hume (University of Nevada School of Medicine, USA)
Cardiac-specific manipulation of ClC-3 gene alters native volume-sensitive
outwardly rectifying anion channels (VSOACs) and heart function in transgenic
mice

11:00-11:30

Takahiro Shimizu, Elbert L. Lee, Tomoko Ise & Yasunobu Okada (Toyama University,
Japan)

Volume-sensitive Cl- channel as a regulator of acquired cisplatin resistance

11:30-12:00

Shintaro Yamamoto & Tsuguhisa Ehara (Fukuoka University, Japan)

Cell-volume regulation in mammalian heart

12:00-12:30

Diego Varela, Antonello Penna, Felipe Simon, Ana Luisa Eguiguren, Elías
Leiva-Salcedo, Francisco Sala & Andrés Stutzin (Universidad de Chile, Chile)Calcium entry modulates the time course for VSOR Cl- current onset in rat
hepatoma cells

12:30-13:30

Poster & Lunch

7

CVR−II
CVR & Cation Channel/Transporters
Chaired by Frank Wehner and Francisco J Alvarez-Leefmans
13:30-14:00

Frank Wehner, Tongju Li, Elmar Endl & Maryna Bondarava (Max-Planck-Institute of
Molecular Physiology, Germany)
The hypertonicity-induced cation channel (HICC) in human hepatocytes: Role inproliferation vs. apoptosis and molecular characterization

14:00-14:30

Shihong Mao & F. Javier Alvarez-Leefmans (Wright State University, USA)
Role of NKCC1 in isosmotic volume control studied in rodent dorsal root
ganglion neurons

14:30-15:00

Rainer Hedrich (University of Würzburg, Germany)
Guard cell volume is controlled by anion channels via draught stress signaling
kinase and phosphatase

15:00-15:30

Miguel A. Valverde, Anna Garcia-Elias, Carole Jung, César Fandos, Gerard
Cantero, José M. Fernández-Fernández & Rubén Vicente
Regulation and pathophysiological relevance of the TRPV4 channel

15:30-16:00

Dandan Sun (Univ. of Wisconsin School of Medicine and Public Health, USA)ER Ca2+ dysregulation and ER stress following in vitro neuronal ischemia: roleof Na+-K+-Cl- cotransporter

16:00-16:30

Coffee BreakCVR−III
CVR & Organic Solute Transport
Chaired by Alexander A. Mongin and Ravshan Z. Sabirov
16:30-17:00

Kishio Furuya, Kyoko Harada, Masahiro Sokabe (Nagoya University, Japan)
ATP-releases via multiple pathways in mammary epithelial cells revealed by
ATP imaging

17:00-17:30

Ryszard Grygorczyk & Sergei N. Orlov (University of Montreal, Canada)
Volume-sensitive nucleotide release from epithelial cells

17:30-18:00

Alexander A. Mongin, Renee E. Haskew-Layton, Alena Rudkouskaya, Timothy J.
Harrigan & Iskandar F. Abdullaev (Albany Medical College, USA)
Redox-regulation of volume-sensitive organic osmolyte release in the brain:mechanisms and (patho)physiological significance

18:00-18:30

Harold K. Kimelberg (Ordway Research Institute, USA)
Pros and cons of glutamate transport through cell volume regulated (CVR)
anion channels in astrocytes: are there therapeutic implications?

18:30-19:00

Ravshan Z. Sabirov & Yasunobu Okada (Institute of Physiology and Biophysics, Uzb.
Acad. Sci., Uzbekistan)
Transport of organic solutes through the maxi-anion channel

8August 5th, Wednesday
PAT−CVR Lectures (Room A)
08:45-09:15

Chairperson: Bernd Nilius

Makoto Tominaga (NIPS, Japan)
Physiological significance of the thermosensitive TRP channels

09:15-09:45

Chairperson: Hideki Sakai

Else K Hoffmann, Kristian A Poulsen, Thomas K Klausen, Signe Kierkegaard, Carl
Frederik Hansen, Ian H Lambert & Stine F Pedersen (University of Copenhagen, Denmark)Regulation of cell volume, proliferation and programmed cell death: Role of ionchannels and aquaporins

09:45-10:15

Chairperson: Shinichi UchidaThomas J. Jentsch (FMP and MDC, Germany)
CLC Cl channels and transporters – biophysics, physiology and pathology

10:15-10:45

Group photo

10:45-12:00

Poster presentation

12:00-13:00

Poster & Lunch

August 6th, Thursday
PAT−CVR Lectures (Room A)
08:45-09:15

Chairperson: Yoshiro Sohma

John. R. Riordan (University of North Carolina, USA)
CFTR at 20: evolving perspectives

09:15-09:45

Chairperson: Makoto Tominaga

Bernd Nilius (Katholieke Universiteit Leuven, Belgium)
Mechano-sensitive TRP channels: facts and fictions

PAT Symposium (Room B)
PAT−IVNew Directions in Cl- Channel Research
Chaired by Michael A. Gray and Criss Hartzell
10:00-10:30

Robert J. Lee & J. Kevin Foskett (University of Pennsylvania, USA)
Molecular mechanisms of cholinergic- and VIP-stimulated Ca2+-dependent fluid
secretion by porcine lung submucosal gland serous cells

910:30-11:00

Nael A. McCarty, Matthew D. Fuller & Christopher H. Thompson (Emory University,
USA)
Novel peptide toxin inhibitors of the CFTR and ClC-2 chloride channels

11:00-11:30

Criss Hartzell, Charity Duran, Qinghuan Xiao, Kuai Yu & Zhiqiang Qu (Emory
University School of Medicine, USA)
Bestrophins and Anoctamins as Molecular Candidates for Ca-activated Cl
Channels

11:30-12:00

Luis J.V. Galietta, Loretta Ferrera, Antonella Caputo, Elvira Sondo, Emanuela Caci,
Olga Zegarra- Moran & Nicoletta Pedemonte (Gaslini Institute, Italy)
Functional and molecular analysis of TMEM16 proteins as plasma membranechloride channels

12:00-12:30

Rebecca A Falin, Rebecca Morrison, Amy-Joan L Ham & Kevin Strange(Vanderbilt University Medical Center, USA)
Identification of Ste20 kinase regulatory phosphorylation sites in a cell cycle andcell volume sensitive ClC anion channel

12:30-13:30

Poster & Lunch

PAT−V
SLC & Organic Anion Transporters
Chaired by Hiroshi Ishiguro and Seth L. Alper
13:30-13:55

Hyun Woo PARK, Joo Hyun NAM & Min Goo LEE (Yonsei University College ofMedicine, Korea)
Regulation of CFTR and SLC26 transporters by [Cl]i-sensitive protein kinases

13:55-14:20

Yoshikatsu Kanai (Osaka University, Japan)
Novel organic anion transporters and new aspects of organic anion transport inrenal proximal tubules

14:20-14:45

Seth L. Alper, Boris E. Shmukler, Liwen Ye, John F. Heneghan, David H. Vandorpe,& Andrew K. Stewart (Harvard Medical School, USA)
SLC4 AND SLC26 Anion Transporters in Flux

14:45-15:10

Daniel Sowah, Danielle E. Johnson, Patricio Morgan & Joseph Casey (University ofAlberta, Canada)
An update on Bicarbonate Transport Metabolons

15:10-15:35

Hiroshi Ishiguro, Ying Song, Shigeru Ko, Takaharu Kondo & Akiko Yamamoto(Nagoya University Graduate School of Medicine, Japan)
Functional interaction between SLC26A6 Cl--HCO3- exchange and CFTR inpancreatic ducts

15:35-16:00

Shigeru B.H.Ko, Akiko Yamamoto, Sakiko Azuma, Hidemi Goto, Shmuel Muallem &Hiroshi Ishiguro (Nagoya University Graduate School of Medicine, Japan)
Pancreatic ductal HCO3– secretion in a disease-implication for the role of ionchannels and transporters

16:00-16:30

Coffee Break10

PAT−VI
Molecular Relation between Anion Channel and Transporter: Evolutional Insight ofAnion Channel/Transporter Molecules
Chaired by Tzyh-Chang Hwang and Tsung-Yu Chen
16:30-17:00

Merritt C. Maduke & Shelley M. Elvington (Stanford University School of Medicine,USA)
Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR

17:00-17:30

David C. Gadsby, Paola Vergani, Martin Mense, Attila Gulyás-Kovacs, Steve W.
Lockless, Luiz Artur Poletto Chaves, & Angus C. Nairn (Rockefeller University,
USA)
Controlling the gates of CFTR, a chloride channel evolved from an ABC
transporter

17:30-18:00

Silvia G. Bompadre, Haruna Miki, Min Li & Tzyh-Chang Hwang (University ofMissouri-Columbia, USA)
Kinetic role of CFTR’s first nucleotide binding domain and its pharmacologicalimplications

18:00-18:30

Joseph A. Mindell (National Institute of Neurological Disorders and Stroke,
NIH, USA)Ins and outs of the lysosomal chloride conductance: biophysics and biology of anorganellar anion transporter

18:30-19:00

Uhtaek Oh (Seoul National University, Korea)
Anoctamin-1, a Cloned Ca2+-activated Chloride Channel and Its Physiological
Implication

19:00-19:05

Closing Remark

CVR Symposium (Room C)
CVR−IVCVR & Cell Signals
Chaired by Stine Falsig Pedersen and Yoshinori Marunaka
10:00-10:30

Ben C.Tilly, Christina H. Lim & Hugo R. de Jonge (Erasmus University Medical
Center, The Netherlands)
Cell volume regulation in intestinal epithelial cells: a role for chloride channel
recruitment?

10:30-11:00

Maria Wiwel, Henrik Klingberg, Donny Ly, András Masszi, András Kapus &Stine Falsig Pedersen (University of Copenhagen, Denmark)Osmotic shrinkage regulates p90RSK, Msk1, and transcription factors CREB and
SRF: effectors in shrinkage-induced modulation of death/survival balance?

11:00-11:30

Niisato N, Ohta M & Marunaka Y (Kyoto Prefectural University of Medicine, Japan)
Dephosphorylation of ERK by MKP-1 stimulates beta- and gamma-ENaC
mRNA expression of renal A6 cells in hypotonic stress1111:30-12:00

Ian Henry Lambert (University of Copenhagen, Denmark)Reactive oxygen species modulate the taurine homeostasis in NIH3T3 mouse
fibroblasts

12:00-12:30

Hideki Sakai, Tomoko Watanabe, Takuto Fujii, Takahiro Shimizu, Yuji Takahashi,
Noriaki Takeguchi, Kazuhiro Tsukada (University of Toyama, Japan)
Osmotic regulation of cell differentiation via aquaporin-5 in human gastriccancer

12:30-13:30

Poster & Lunch

CVR−V
CVR & Cell Functions
Chaired by Markus Ritter and Vladimir Strbak
13:30-14:00

A. Fabian, T. Fortmann, O. Lindemann, V.C. Bomben, H.W. Sontheimer, E.K.
Hoffmann & A. Schwab (University of Muenster, Germany)
Do TRPC1 channels modulate mechanosensitive signalling during cell
migration?

14:00-14:30

Martin Jakab, Sabine Schmidt, Angelika Moder-Dzeladini, Arnulf Hartl, ChristianLangelueddecke, Renata Sanovic, Sofya Bulatova, Eva Iglseder, Clemens Hufnagl,
Heidi Mair, Martin Gaisberger, Markus Ritter (Paracelsus Medical University, Austria)
The functional role of the non-gastric H+/K+-ATPase ATP12A (ATP1AL1) as
anti-apoptotic ion transporter

14:30-15:00

Mingmin Chen, Anurag Singh & Ursula Seidler (Hannover Medical School,
Germany)
Coupling of nutrient and electrolyte transporters in the small intestine

15:00-15:30

Rodrigo Franco (CINVESTAV, IPN. Mexico City, Mexico)Efflux of organic molecules as signaling events in cell volume regulation andapoptosis

15:30-16:00

Vladimir Strbak, Zuzana Bacova, Jana Galcikova, Jana Matejikova, Martina Orecna,
Roman Hafko & Tana Ravingerova (Slovak Medical University, Slovakia)
Cell swelling-induced peptide secretion; possible pathophysiologicalimplications

CVR−VICVR & Cell Death
Chaired by Florian Lang and John A. Cidlowski
16:30-17:00

Florian Lang, Michael Föller, Daniela Kempe, Ekatherina Shumilina, Guiscard
Seebohm, Nathalie Strutz-Seebohm & Volker Vallon (Eberhard-Karls-University of
Tuebingen, Germany)
The functional significance of the cell volume regulated kinase SGK1

17:00-17:30

Carl D. Bortner & John A. Cidlowski (National Institute of Environmental Health
Sciences, NIH, USA)
A Lymphoid Cell Model designed to Evaluate the Role of RVI and RVD in
Apoptosis (Part A)12

17:30-18:00

John A. Cidlowski & Carl D. Bortner (National Institute of Environmental Health
Sciences, NIH, USA)
A Lymphoid Cell Model designed to Evaluate the Role of RVI and RVD in
Apoptosis (Part B)

18:00-18:30

Tomohiro Numata, Frank Wehner, Kaori Sato & Yasunobu Okada (Kyoto University,
Japan)
Cation channel activity determines cell death in human epithelial cells

18:30-19:00

Sergei N. Orlov, Olga Akimova, Johanne Tremblay & Pavel Hamet (University ofMontreal Hospital Research Center, Canada)
Oncosis in cardiotonic steroids-treated cells: evidence for Na+i,K+i-independent
α1S-Na+,K+-ATPase- and p38-mediated signaling

19:00-19:05

Closing Remark

13

Poster presentations
P-01

Identification of Ste20 kinase regulatory phosphorylation sites in a cell cycle
and cell volume sensitive ClC anion channel
Rebecca A Falin, Rebecca Morrison, Amy-Joan L Ham & Kevin Strange

P-02

Identification of novel CLC Chloride-Channel Inhibitors
Merritt C. Maduke, Andrew Howery & Justin Du Bois

P-03

Two Different Binding Sites for Small Aromatic Carboxylic Acids in CFTR
Ying-Chun Yu, Yumi Nakamura, Tomoka Furukawa, Yoshiro Sohma, Zhen Zhou, Masato
Yasui & Tzyh-Chang Hwang

P-04

Open-channel block of the CFTR Cl- channel by loop diuretics
Jia Liu, Min Ju, Toby S. Scott-Ward, Zhiwei Cai & David N. Sheppard

P-05

Cardiac
CFTR
exertsa
protective
actionagainstischemia/reperfusion-induced myocardial infarction in vivo and necrotic
death of cardiomyocytes in vitro
Hiromi Uramoto & Yasunobu Okada

P-06

Activation of cardiac ventricular ATP-sensitive potassium channel by Clchannel blocker NPPB
Da Li, Fu-Cheng Xiao, Wu-Ping Sun, Yi-Ming Zhou, Li-Bin Zhang & Shi-Sheng Zhou

P-07

Cholesterol depletion modulates the taurine homeostasis in Ehrlich-Lettré
cells
Kasper Rømer Villumsen, Lars Duelund & Ian Henry Lambert

P-08

Role of membrane cholesterol in insulin secretion from pancreatic islets andinsulinoma tumor cells
Zuzana Bacova, Martina Orecna, Peter Kohut, Ivan Hapala, Roman Hafko & Vladimir
StrbakP-09

Formation of symmetric and asymmetric DAPC-DLPC lipid bilayer rafts
Sabine Schmidt, Martin Jakab, Markus Ritter Markus Paulmichl & Robert Henderson

P-10

The non-gastric H+/K+-ATPase ATP12A exerts an anti-apoptotic effect onbutyrate-treated myelomonocytic HL60 cells
Sabine Schmidt, Davide Mercorillo, Clemens Hufnagl, Sofya Bulatova & Martin Jakab,
Markus Ritter

P-11[Ca2+]i and [Cl-]i alterations in migrating glioblastoma cells
Tatsuro Kumada & Atsuo Fukuda

P-12

Hypotonicity-induced [Ca2+]i elevation of principal cells in isolated rat
kidney cortical collecting ducts
You Komagiri, Toshiyuki Kojo, Kazuyoshi Nakamura & Manabu Kubokawa

P-13

The Role of ANO (TMEM16) Family of Proteins Expressed in Human
Pancreatic Acinar Cells
Joo Hyun Nam, Jae Seok Yoon, Uhtaek Oh & Min Goo Lee

14

P-14

The role of AMPK in the regulation of insulin secretion and proliferation in
INS-1E rat insulinoma cells at standard cell culture conditions
Langelueddecke, C., Jakab, M., C.Hufnagl, & Ritter, M.

P-15

Activation of TASK-2 by a tyrosine phosphorylation of the channel
Signe S. Kirkegaard, Steen Gammeltoft, Ian H. Lambert, Else K. Hoffmann

P-16

Regulation of WNK1 kinase activity by extracellular ionic conditions
Shotaro Naito, Akihito Ohta, Eisei Sohara, Tatemitsu Rai, Sei Sasaki & Shinichi Uchida

P-17

Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH
Hisayoshi Hayashi, Kazuhito Suruga, Yukari Yamashita & Yuichi Suzuki

P-18

Na+ H+ exchangers (NHE) and the Cl- -HCO3- exchanger (AE2) contribute toregulatory volume increase in epithelial cells isolated from the choroid
plexusAlexandra L H Hughes, & Peter D Brown

P-19

The apical Cl-/HCO3- exchanger DRA mediates Cl absorption and HCO3secretion in the murine large intestine
Suzuki Y, Kawamata K, Ooba, Schweinfest CW, Soleimani M & Hayashi H

P-20

Resveratrol inhibits stimulus-secretion-coupling and induces apoptosis in
INS-1E rat insulinoma cells
Martin Jakab, Cornelia Bortolotti, Thomas Kunit, Christian Langelueddecke & Markus
RitterP-21

Role of AQP5 in cisplatin-induced cell death in Ehrlich ascites tumor cells
Hansen C F, Hoffmann E K & Poulsen K A.

P-22

New aspects of AVD and roles of putative anion channels
Grubb, S., Poulsen, KA., Klausen, TK., Larsen, EH. & Hoffmann, EK.

P-23

Role of TRPV4 in cartilage – insights from a porcine model
Wolfgang Liedtke, Suk Hee Lee, Holly Leddy & Farshid Guilak

P-24

Reduced volume-regulated outwardly rectifying anion channel activity inventricular myocyte of type 1 diabetic mice
Shintaro Yamamoto

P-25

Regulation of bradykinin-induced activation of volume-sensitive outwardly
rectifying (VSOR) anion channels via “Ca2+ nanodomains” in mouse corticalastrocytes
Tenpei Akita & Yasunobu Okada

P-26

A novel role of arginine-vasopressin released from osmosensory neurons inhypoosmolarity conditions
Kaori Sato, Tomohiro Numata, Yoichi Ueta & Yasunobu Okada

P-27

The hydrogel nature of mammalian cytoplasm contributes to osmosensing
Johannes Fels, Sergei N. Orlov, Ryszard Grygorczyk

P-28

Role of ion channels in the cell volume regulation of thymocytes
Ranokhon S. Kurbannazarova, Yasunobu Okada & Ravshan Z. Sabirov

15

P-29

Cell volume regulates nhe3 activity via altering an electostatic interaction
between the cytosolic tail of the exchanger and the inner leaflet of the plasma
membraneR. Todd ALEXANDER, Tony YEUNG, Wendy FURUYA, Iskra PELTEKOVA, John ORLOWSKI &Sergio GRINSTEIN

P-30

Reactive Oxygen Species from Mitochondria and NADPH Oxidase Mediate
Activation of Volume-Sensitive Chloride Current by Endothelin-1
Wu Deng, Clive M. Baumgarten

P-31

Temporal release of GABA regulates granule cell precursors (GCPs)
proliferation during rat cerebellar cortical development
Toshitaka Morishima, Tatsuro Kumada, Chitoshi Takayama, Sachiko Yoshida Atsuo Fukuda

P-32

Astrocytic responses to GABA spill-over from synaptic clefts and theirfunctional role for regulating extracellular Cl- in hippocampus
Kiyoshi Egawa, Junko Yamada, Tomonori Furukawa, Yuchio Yanagawa & Atsuo Fukuda

P-33

Neurogenesis of GABAergic interneurons but not of cortical plate cells in the
fetal cerebral cortex was decreased by maternal stress
T. Uchida, T. Morishima, T. Furukawa, Y. Oki, T. Kumada, Y. Yanagawa & A. Fukuda

P-34

Clustering of neuronal K+-Cl- cotransporter in the lipid rafts by tyrosine
phosphorylation
Miho Watanabe, Hiroaki Wake, Junichi Nabekura

P-35

K+-Cl- cotransporter-4 associated with H+,K+-ATPase is involved in themechanism of HCl secretion in the apical canalicular membrane of gastricparietal cells
Takuto Fujii, Kyosuke Fujita, Takahiro Shimizu, Yuji Takahashi, Yoshiaki Tabuchi,
Magotoshi Morii, Noriaki Takeguchi & Hideki Sakai

P-36

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