Refillable MEMS Drug Delivery Pump for Chronic Ocular Diseases -- L...

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Invest Ophthalmol Vis Sci 2007;48: E-Abstract 2246.
© 2007 ARVO

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Refillable MEMS Drug Delivery Pump for Chronic Ocular Diseases
R. Lo1A, P.-Y. Li1B, J. Shih2C, S. Saati3, R. Agrawal4, Y.-C. Tai2D, M. Humayun5 and E. Meng1AA
Biomedical Engineering, BMaterial Science, 1Viterbi School of Engineering, University of Southern California, Los Angeles,California
CElectrical Engineering, DBioengineering and Electrical Engineering, 2California Institute of Technology, Pasadena, California
3Ophthalmology, Doheny Eye Institute at the Keck School of Medicine, University of Southern California, Los Angeles, California
4Ophthalmology, Doheny Eye Institute at the Keck School of Medicine, University of Southern, Los Angeles, California
5Ophthalmology, Doheny Eye Institute at the Keck School of Medicine, Los Angeles, California

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Commerical Relationships: R. Lo, Bausch & Lomb, F; California Institute of Technology, P; P. Li, Bausch & Lomb, F; California Institute of Technology,
P; J. Shih, Bausch & Lomb, F; California Institute of Technology, P; S. Saati, Bausch & Lomb, F; R. Agrawal, Bausch & Lomb, F; California Institute ofTechnology, P; Y. Tai, Bausch & Lomb, F; California Institute of Technology, P; M. Humayun, Bausch & Lomb, F; California Institute of Technology, P;
E. Meng, Bausch & Lomb, F; California Institute of Technology, P.
Support: NSF Grant EEC 0310723, Bausch & Lomb

Abstract
Purpose:Develop a refillable ocular drug delivery device for targeted therapeutic delivery.
Methods:Two different approaches to drug delivery, manually- and electronically-controlled pumping with MicroElectroMechanical Systems (MEMS)
devices were developed as an alternate treatment method for intraocular drug delivery. Both systems share a common layout, containing a refillable drug
reservoir and a cannula. The manually-controlled device contains a restrictor valve that prevents backflow. The device is implanted subconjunctivally withthe cannula tip positioned in the anterior or posterior segment. Drug dispensation occurs when the reservoir is depressed by the patient, or due to gas
generation associated with electrolysis. Reservoir is refilled with a modified 30 gauge needle. This device allows long-term treatment following a single
surgical intervention.
Results:Bench top and surgical tests confirmed one-way bolus dispensation from the valved manually-controlled device. Bolus or continuous dispensation(nL/min), with a fixed or variable rate, from the electronically controlled device was correlated to applied current. Bench top tests demonstrate 229.6nL/min
with a standard error of 19.7nL/min at 50µA of applied current. Refillability has been assessed in bench top and surgical experiments. A non-coring 30G
needle was used to repeatedly puncture the reservoir material in the same location. After 24 punctures, internally pressurized reservoirs are able to contain
fluid below 230 mmHg.
Conclusions:A device capable of intraocular drug delivery with targeted doses to treat chronic ocular diseases is demonstrated.
Key Words: injection • retina • quality of life

© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract inany form must be obtained in writing from the ARVO Office prior to publication.

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6/20/2007 1:07 PM