June 30, 2020

Motohiro Horiuchi, Dean
Faculty of Veterinary Medicine,
Hokkaido University, Japan
HOKKAIDO UNIVERSITYWISE Program for

One Health Frontier1

Graduate School of ExcellenceConcept of One Health
One Health is NOT a new concept, but it has become more important inrecent years. This is because many factors have changed interactions
between people, animals, and our environment.

One Health is an approach to ensure the well being of people, animals
and the environment through collaborative problem solving — locally,nationally, and globally (UC Davis).

One Health is defined as a collaborative, multisectoral, andtransdisciplinary approach — working at the local, regional, national, andglobal levels — with the goal of achieving optimal health outcomesrecognizing the interconnection between people, animals, plants, and theirshared environment (CDC).

History of One Health
Hippocrates – Virchow – Schwabe - Manhattan Principles

The term “One Health” is fairly new,the concept has long been recognized.

The presentation falls roughly into two
halves, the first detailing various
environmental factors that
contribute to specific diseases

Hippocrates on airs, water, and places

History of One Health
Hippocrates – Virchow – Schwabe - Manhattan Principles

Link Between Human and Animal Health“Zoonosis and One Medicine”
Rudolf Virchow

Rudolf Virchow (1858)
Father ofmodern pathology

The origin of the One Medicine concept has
been linked to the 19th century German
physician and pathologist, Rudolf Virchow,whose discoveries on Trichinella spiralis in pork
led to valuable public health measures.
Virchow coined the term “zoonosis” andproclaimed that there should be no dividing
line between human and animal medicine.

Gyles C. One Medicine, One Health, One World. Can Vet J. 2016;57(4):345–346.

History of One Health
Hippocrates – Virchow – Schwabe - Manhattan Principles

The Relation of Animals to Man“Comparative pathology”
William Osler
Canadian physician and pathologist Sir
William Osler at McGill College andveterinary students at the Montreal
Veterinary College in the 1870s.

Osler published on the relation of animals toman and promoted comparative pathology
and the One Medicine Concept.
Father ofVeterinary Pathology
Gyles C. One Medicine, One Health, One World. Can Vet J. 2016;57(4):345–346.

One Health: Sound living environment to the next generation!
健全な生活環境を次世代に！

HumansAnimals

For the healthon the earth

SocietyEnvironment

One Health approachtrans-sectoral collaboration forthe health of humans, animals, and environment

Veterinary
sectors

Epi-Center

Medicalsectors

Health Science
sectors

Environment
sectors

One Health (approach)R&D
Institutions

Risk management
authorities
ResearchInstitutions

Risk analysis
authorities
Educationorganization

Firm specialty
in respective field(need experience)

Collaboration
communication fortackling and solving health problems(need experience)

Concept of One Health
One Health is NOT a new concept, but it has become more important inrecent years. This is because many factors have changed interactions
between people, animals, and our environment.

One Health is an approach to ensure the well being of people, animals
and the environment through collaborative problem solving — locally,nationally, and globally (UC Davis).

One Health is defined as a collaborative, multisectoral, andtransdisciplinary approach — working at the local, regional, national, andglobal levels — with the goal of achieving optimal health outcomesrecognizing the interconnection between people, animals, plants, and theirshared environment (CDC).

21 Century Center of Excellence Program (MEXT)“Program of Excellence for Zoonosis Control (2003-2007)”
By Grad. Sch. Vet Med, Grad Sch. Med,Research Center for
Zoonosis Control (2005-)

Global Center of Excellence Program (MEXT)“Establishment of International Collaboration Centers for Zoonosis Control (2008-2012”
By Grad. Sch. Vet Med, RCZC, Grad Sch. Med, Inst. Genetic
Zoonosis Control Expert Program (2009-)
Program for Leading Graduate Schools (MEXT)“Fostering Global Leaders in Veterinary Science Contributing to One Health(2011-2018)”
By Grad. Sch. Vet Med, RCZC, Grad Sch. Med, Inst. GeneticGraduate School of Veterinary Medicine

Reorganize two
graduate schools(2018-)
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Graduate school of Infectious Disease「卓越大学院プログラム」は、各大学が自身の強みを核に、これまでの大学院改革の成果を生かし、国内外の大学・研究機関・民間企業等と組織的な連携を行いつつ、世界最高水準の教育力・研究力を結集した5年一貫の博士課程学位プログラムを構築することで、あらゆるセクターを牽引する卓越した博士人材を育成するとともに、人材育成・交流及び新たな共同研究の創出が持続的に展開される卓越した拠点を形成する取組を推進する事業です(From MEXT)

Based on strong points➢ Infectious diseases, chemical hazards, animal sciences, university withmedical and veterinary school and environmental science
Utilize outcomes of graduate school reformation➢ Achievement of Leading Program

Promote functional collaboration and cooperation with universities, institutions, andcompany domestically and internationally to provide a qualified, world-class-rank
graduate school program➢ Outstanding international network with reliable counterparts establishedby 21COE, GCOE, LP, and other programs
Organize the highest educational institutions
to foster highly qualified PhD who can lead various sectors internationally11
to innovate and create novel social values

本プログラムが御旗に掲げる“One Health”の実現には、医学、獣医学、環境科学などの学問領域、および発生現場、医療、研究開発、教育およびリスク管理などに関わる機関が協働する“One Health approach”が必要です。本プログラ
ムでは、感染症・化学物質・動物科学に関する教育研究リソースを活用し、先端的な研究を推進します。信頼できるカウンターパートを有するグローバルネットワークを活用した国際共同・調査研究、WHO、JICAなどの国際行政・協力機関との連携、企業との連携による開発研究など、One Healthに関連する多くの経験を大学院生に積ませることを通じて、疾病制御・予防の理念を明確にもち、バランス感覚に優れた国際性と俯瞰力を備え、One Healthに係る諸問題を解決できる専門家を育成します。

To ensure the critical concept of this program “One Health”, multi-disciplinary collaborationsuch as medicine, veterinary medicine, and environmental science, and trans-sectoral
cooperation with human and animal health sectors, education, research and development
institutions, and risk management authorities, in other words, “One Health Approach”, isessential. In this program, we promote advanced researches using excellent research andhuman resources and outstanding experiences on infectious diseases, chemical hazard, andanima and life sciences for contributing One Health. Additionally, PhD course students will
gain a variety of experiences of international collaborative research with reliable counterparts,cooperative activity with international organization such as WHO, OIE, and JICA, and/ordevelopment research in collaboration with public institution and company. This program aims
at fostering professional/expert (prominent PhD) who will be able to tackle and resolve
problems related to One Health, with a definite idea for disease control and prevention, aholistic viewpoint, a well-balanced international sense, and a comprehensive competence fordecision-making and problem-solving.
12Multi-sectoral and multidisciplinary collaboration
are required for ensuring One Health
Medical side
✓ Grad Sch Med✓ Grad Sch Pharma✓ Grad Sch Denti✓ Grad Sch Health Sci✓ Hospital✓ Center Environ Health Sci

Prominent Institutes

Platoform for HRD✓ Firm specialty✓ Comprehensive✓ Multi-disciplinarysuperior✓ Leadership
PhD ✓ Team workOIENitobe✓ Holistic viewpoint✓ Practical✓ Originality✓ Think ahead✓ Global✓ Transferable skill

International organizationWHO

One HealthMulti-disciplinary

Human resource educationand development

Research & development
Diagnosis & treatment

Antibody
Fuso Co Ltd

Collaborationinternationally

Collaboration withregistered university
Obihiro U
OIE-RL

ZambiaJICA

Shionogi

Other Univ

Field, Int’L cooperation

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Grad Sch Vet Med
Grad Sch Inf Dis
RCZC
GI-CoRE
Grad Sch Environ Sci

✓✓✓
✓✓

UCD

NIH

Resources at HU

Veterinary and environ sideRGU
OIE-JCCWhere superior PhD are needed

育成する人材の輩出先
Disease control andprevention at Epicenter
発生現場での疾病制御・予防

Academia
教育研究機関Prominent
researchInstitute,Universities

One Health Approach

Government,Cooperation agency
国内外行政機関
国際協力機関WHO、OIE、JICA,
MAFF, MHLW,NPO, NGO✓ Researches and human resource✓ Firm specialty
development for disease control,✓ ComprehensivenessSuperior✓ Multi-disciplinary✓ 疾病制御に資する基盤研究・教育と人材育成✓ 医学・獣医学の連携による新規価値の創出
PhD ✓✓ Leadership
Team work✓ Innovation✓ Holistic viewpoint✓ Practical✓ Originality✓ Think ahead✓ Global✓ Transferable skill

Int’L human resource network
is supreme property
人材ネットワークは至高の財産✓ Int’L frame work for disease control✓ 疾病制御の国際的枠組み構築✓ Avoiding social damages and improvement ofproduction✓ 社会経済的損失の回避、生産性の向上

R&D
研究開発機関Pharmaceuticalcompany,
Vaccine maker,
Bio Venture etc✓ Development of vaccine, diagnostic,
treatment✓ 新規ワクチン、診断・治療法、検査法の開発✓ Early warning and response system✓ 異常の早期検知システムの構築

✓ Int’ framework for Dis Cont
✓ Enhance food safety✓ Promotion Conser MedRes/Edu
sectors

GovernAgency✓ Innovation for Dis Cont/Prev

One Health Approach
Int’L
collaboration

One Health Allied
Collaborators✓ Human resources for Dis Cont/Prev

R&Dsectors✓ Soundness of environment

Medicalsectors

Professional for One Health Leader

協働One Health Frontier PhD Program（4Y course, 20/year）
One Health Ally course
Inter and inter program for
fostering mindset forcontributing to One Health

OH module

Ⅰ&II. Based on curriculum ofGrad Sch Inf Dis & Vet
MedIII. Independent module
IV. One Health module

WHO、OIE、JICA etc

Human resource
exchange

Shionogi, Fuso etc

Intra HU
Med, Dentis,Pharma, HealthSci, Hospital,Environ HealthSci, Genetics

Obihiro Univ

Center of Diagnosis and Disease Control）

Inter Univ
Obihiro U, RGU

Selection（Essay, interview)
All Grad Schs

15

Grad Schs related toMedicine, Life Science

Grad SchInf DisInternational org

Vet Med, Inf Dis
Vet Med,
RCZC, Med,GI-CoRE

Mutli-desciplinary team

RGU

Cooperative
Institution

Grad Sch
Vet MedCoompany

Research & education
NIH、UCD、Ednburgh、Conell、Corolad、
Zambia etc

Goverment
MAFF、MHLW、NIID、NIAH

One Health Ally Course
Soundness of life and environment for next
generation

Fostering mindset for collaboration for One
Health globally

Practical training
overseas

4. Practical training overseas
Experience on One Health Approach

Inv heavy metal contam(Ethiopia)

One Health Ally Course

Surveil filo virus(Zambia)

3. Improvement of cooperation skill

4.OH on site training
Cooperation
with HRDat HU

Practicaltraining forcooperation

3.OH collaborative training

2.OH transferable skill training
1.OH seminar

RakunoGakuen Univ

ObihiroUniv

Manage Avian flu

Rumor surveil EID(FAO Viet man)(WHO Phillipine)

2. Improvement of transferable skills

Transferableskill training

HUWorkshop for problem-solving
with team work

1. Basics of One Health

One Health Ally Course is Intra- and Inter-University Special Program ofgraduate school education for fostering mindset for contributing One Health(HU PhD students both for natural sciences and humanity as well as PhD16
students of RG and OU can join)Based on research and education resources by 21COE, GOCE, and Leading
Program, and multi-disciplinary collaboration with variety sectors including
human health, animal health, and environmental healthThis program aims at fostering professional/expert (superior PhD) who will
be able to tackle and resolve problems related to One Health, with a definite
idea for disease control and prevention, a holistic viewpoint, a well-balanced
international sense, and a comprehensive competence for decision-making
and problem-solving
For the health of human, animal, and the planet（One Health）

17