Application for Academy Center Certification
World Premier International Research Center Initiative (WPI)
Host Institution

University of Tsukuba

Research Center

International Institute for Integrative Sleep Medicine (IIIS)

Host Institution Head
Center Director
Administrative Director

NAGATA Kyosuke
YANAGISAWA Masashi
KIMURA Mayumi

Please prepare this application based on the content of your Center’s progress report and the progress plan you submitted for the Center’s
final evaluation. Summarize the Center’s future plans with regard to the following 8 items within five A-4 pages. (Also fill out the
appendices at the end of this form.)

1. Overall Image of Your Center* Describe the Center’s overall image including its identity.

Sleep is a behavior that everyone experiences daily and takes up as much as one third of one’s entire
lifetime. Although desiring to sleep is a fundamental instinct, its regulatory mechanism as well as raisond’ȇtre remain yet fully uncovered. Sound sleep is essential to maintain physical and mental health.
Accumulation of sleep insufficiency, so-called sleep debt, increases risks for depression, obesity, dementia
and even cancer. Sufficient sleep is requisite also for efficient daytime performances. A lack of sleep inJapanese working population is the worst among advanced nations, costing the economy up to $138 billion
a year. Such a “sleep underdeveloped country” definitely needs a world-class research institute for sleep
medicine. International Institute for Integrative Sleep Medicine (IIIS) of University of Tsukuba hasserved the role, and the scientific significance is well recognized both inside and outside of Japan.
To accomplish world-leading research on sleep, IIIS has given continuous challenges of solving themystery of sleep with cutting-edge technologies and committed our research outcomes to social
implementation. During the past 10 years since the Center launching, IIIS led by Center Director
Yanagisawa has accumulated an official reputation and by now is globally acknowledged as one of theFig. 1. Core group principal investigators and the scientific structure at IIIS beyond FY2022.

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leading sleep research institutes. One of the approaches the Director made for the success was aggressive
recruitment of principal investigators (PI) who have a variety of skills and knowledge on sleep researcharound the world (Fig. 1). Especially recruiting young PIs who are returner to Japan has become apowerful addition scientifically and internationally. Secondly, IIIS has expanded to include human sleep
lab and established a subset of the translational research division. Further, S’UIMIN Inc., established as a
spin-out from IIIS, has successfully developed their own wearable EEG-measuring device with AI-basedalgorithms. Their business facilitates bigdata analysis and eases in-house sleep diagnosis as well.
Opportunities have opened up by searching biochemical changes underpinning sleep-wake cycles toapplied physiology and data science targeting human health and treatment options.
In addition, we must mention the discovery of an inducible hibernation-like state in non-hibernator rodents,
by the research group of Vice Center Director Sakurai. The second hypomobile behavior, hibernation, isanother mystery in neuroscience. This recent finding was a breakthrough to realize human synthetic
hibernation. If the application of this technique becomes possible, a window of opportunities will widely
open for emergency cares to reduce mortality and sequelae or even applied to a long journey to Mars.
To further solve the mystery of 2 types of hypomobility, i.e., sleep and hibernation, we continuously
devote our scientific activities to following objects.

1. To elucidate the fundamental mechanisms of sleep/wake regulation
2. To elucidate molecular pathogenesis of sleep disorders and related diseases
3. To develop and verify treatment strategies for sleep disorders
4. To elucidate the fundamental mechanisms of hibernation regulation

To accomplish these objectives, we have so far conducted wide-ranging research, covering a scope froma) basic biology such as neuroscience and molecular genetics to b) pharmaceutical science, c) humanphysiology, and d) data science. We thus aim to create the new interdisciplinary research domain, “sleep
science” by fusing these research fields. Further, it is requisite that IIIS continuously makes the efforts tosecure sufficient external research funds and to increase and expand collaboration/research alliances
especially in the field of translational research with outside groups including the collaboration groups in
University of Tsukuba, the overseas Satellites, external research institutions, and private companies. Most
recent success on acquiring external research funds was Moonshot R&D Program operated by Japan
Agency for Medical Research and Development (AMED) (>¥3,000 M for 5 years starting in FY2021). Hence,sustainability of IIIS is very visible within University of Tsukuba and amongst WPI Centers as well.

2. Mid- to Long-term Research Objectives and Strategies* Describe new challenges in the Center’s research objectives and plans after FY2022.

To realize a society where various issues of sleep are well managed to prevent diseases caused/worsened
by severe sleep debts
Sound sleep is essential for maintaining physical and mental health; losing sleep chronically poses
immense, medical, and social problems. We thus aim to overcome sleep double and resulting sleep
disorders from which more than 20% of people in developed countries suffer, in order to let people enjoy
the lives with relief and release from any sleep-related problems. To save our ordinary life or even improve
our daily quality of life, we strategically aim for this vision as the mid-term objective.
To realize a society where innovative emergency medical care based on hibernation is implemented tosave lives even in disasters
Last year, the Vice Center Director of IIIS discovered a group of neurons (Q-neurons) in the hypothalamus
whose forced-activation induces a hibernation-like state in mice. Besides sleep, hibernation is anotherbehavior that is characterized as regulated hypomobility. The hypomobile behavior adapted to the rotationof the earth is sleep, while another hypomobile behavior accommodated to the revolution of the globe ishibernation. Revealing similarities and differences between sleep and hibernation would lead us to better
understanding of both hypomobile behaviors. The characteristics of hibernation, hypometabolism reduces
systemic oxygen demand drastically and could offer an effective critical care to avoid tissue injuries andnecrosis under hypoxia/anoxia. We thus try this as the long-term objective.
Expanding our research subject from sleep to 2 hypomobile behaviors (sleep and hibernation), IIIS aims
for ensuring to achieve our vision, having people enjoy their lives with relief and release from healthconcerns until 100 years old.
Setting out 5 specific goals as below, we will accomplish our both mid- and long-term objectives
mentioned above and provide substantial benefits to everyone.
1. To develop methods to control homeostasis of sleep to save more time to improve QOL

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IIIS2. To develop preventive measures against diseases caused/worsened by severe sleep debts
3. To develop methods to predict risks to be suffered from diseases caused/worsened by sleepdebts
4. To build a model of the medical network offering sufficient cares for sleep disorders to everyonein the world
5. To develop innovative emergency medical care using the hibernation technology to save lives
even in disasters

3. Management System of the Research Organization* Describe the system of organizational management via which the center will execute the above-described research strategy and plan.
* In Appendix 1-3, list the Principal Investigators, enter the number of center personnel (researchers, research-support staff, andadministrative staff), and provide a diagram of the Center’s organizational management system.

To implement the research strategy and plans outlined above, as of April 1, 2021 we have organized a
new project consortium, consisting of all the PIs in Core Group of the Center (IIIS) and PIs of new
Collaborative Groups in University of Tsukuba and new Satellites (refer to Appendix 1 for the details). The
new project shall be financed mainly by AMED Moonshot R&D Program. The Center Director, Masashi
Yanagisawa stays in the position as it is and will also serve as the project manager (PM) of the Moonshot
R&D Program.
To strengthen our capability of systems biology/mathematical analyses further, we recruit a new PI fromthe University of Tokyo. We also invite 2 computational scientists in University of Tsukuba as the membersof University of Tsukuba Collaborative Group and invite 2 more computational scientists from Keio
University and Tohoku University as the members of the Collaborative Groups. We nominate also a
specialist of non-human primate in University of Tsukuba as a new member of the Collaborative Group forthe hibernation study, while we keep good relations with the PIs of the current Collaborative Groups andcontinue ongoing collaborations with them. Among current Satellite PIs, R. Greene, the University of Texas
South Western Medical Center (TX, USA) and Q. Liu in National Institute of Biological Sciences, Beijing(China) continue to join the new project. Clifford Saper, Beth Israel Deaconess Medical Center (MA, USA)and Vladyslav Vyazovskiy, Oxford University (UK) additionally join the new project as well.
Regarding the Administration, M. Kimura will stay in charge as the Administrative Director, while T.
Kokubo, the former Administrative Director, is reappointed as a High Class Research Administrator to
support the PM of the Moonshot R&D Program. No major structural changes in the Administration would
occur under an expected subsidy from WPI Academy.

4. Plan for Promoting the International Circulation of World’s Best Brains* Describe your policy and concrete plan for promoting the international circulation of the world’s best brains, which is an important functionof the WPI Academy.

Overseas PIs, i.e., Liu, Greene, Saper, and Vyazovskiy, have been actively participating in research
activities with IIIS members through UTSW, NIBS, BIDMC, and Oxford, respectively. Not only to science,
they also contribute to the management of IIIS by joining the PI meeting held monthly even when absent
from the institute, or via online (currently this is the ordinal setup) and take an active part in important
events such as symposia hosted by IIIS. In addition, we will start Moonshot Work in Progress online
meetings (MSWIP) including these overseas satellite members every month from FY2022. IIIS will
strengthen the international relationship by the support of WPI Academy subsidy.
To WPI-IIIS Annual Symposia, totally 43 outstanding foreign researchers have been invited from abroadin order to share the latest achievements in sleep research or relevant fields and most importantly tocommunicate for global networking. Moreover, we regularly hosted 170 WPI-IIIS Seminars where we
invited domestic and foreign researchers in sleep/neuroscience fields almost every other week; 68 overseas
speakers gave us lectures, by which the ratio of foreign speakers reached 41% since the inauguration in
December 2012. We hope that WPI-IIIS Symposia and WPI-IIIS Seminar series can be held onsite
FY2022 onwards again. These events definitely stimulate all researchers in IIIS, University of Tsukuba as
well as WPI Centers and other colleagues collaborating with us.
To build up a supporting system for overseas researchers, IIIS has concluded the agreement on support
for foreign researchers with Japan International Science and Technology Exchange Center (JISTEC).
They offer services of accompanying foreign researchers to the City Hall for the residence registration,
opening a bank account, etc. Further, many IIIS foreign researchers reside in the international
accommodations operated by JISTEC.
University of Tsukuba also fully supports them via a unique department, “University of Tsukuba, Global
Commons, International Exchange Support Office” which engages in livelihood support for foreign

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researchers and their families. They provide information on accommodation for foreigners in- andoutside the University and daily life in Tsukuba, and offer services including Japanese classes, proxyapplication for the certificate of eligibility (visa), etc. Another supporting system by the Departmentof Research Promotion offers a fund to Ph.D. candidates for Research Assistant (RA) position.
Moreover, University of Tsukuba has been selected as a recipient of JST SPRING (Support for Pioneering
Research Initiated by the Next Generation). Indeed, many of IIIS students have been already supportedby this program. Infiltrating across campus, IIIS Research Assistantship will strategically continue.
Speaking of the international circulation of World’s best brains, IIIS has started preparing a proposal
for a new Kakenhi RECONNECT Initiative (Research Excellence through International Collaboration
and Network Construction). We accelerate the international exchange through this program, sending out
and receiving in young potentials vigorously, to stimulate further spirit of global thinking and acting acrossinternational partners. Worth specially mentioning is that University of Tsukuba has facilitated theInternational Tenure-Track System under the Program for Promoting the Enhancement of Universities.
Young faculty candidates accepted by the system will have chances to work abroad for a couple of years
within the 5-yr term before tenure evaluation. Such opportunities will be further increased by the
University’s newly commenced program entitled “Nurturing Trans-border Researchers Crossing Countries,
Disciplines and Industry-university-government Sectors” upon the recent award of “Strategic
Professional Development Program for Young Researchers” in FY2021 by MEXT. IIIS encourages
our members to apply for the system to activate international brain circulation effectively.

5. Plan for Disseminating the WPI Program Achievements* Describe your policy and concrete plan for disseminating WPI center achievements both within the host institution and to other universities,
especially their experience and know-how accumulated on establishing top world research institutes and advancing system reforms.

IIIS has given a major impact on the reform of University of Tsukuba. During the third mid-term plan
starting from FY 2017, the University aims to pursue the globally unrivaled frontier research, i.e., theresearch for quest for truth and innovation contributing to society. To achieve the goals, the University
has made a plan of reorganization/restructuring/merger of all research centers. Accordingly, the research
centers have been classified by function into the Advanced Research Centers and the Research
Support Centers. The former has been further classified as R1 (World-class Research Center), R2(National-class Research Center), R3 (Developing Research Center), and R4 (Research Unit) to facilitate
strategic resource allocation. Center for Computational Science (CCS) and Life Science Center for Survival
Dynamics, Tsukuba Advanced Research Alliance (TARA) are classified as the R1 status of World-classResearch Center in physics and bioscience, respectively. Besides the research center’s
reorganization/classification, the University established Organization for Development of Global Centers in
March 2020 to implement its objectives through the comprehensive support provided by the creation ofan ‘On-campus Special Zone for Research Strategy’ and strategic allocation of the University’s researchresources. IIIS and R1-accredited CCS and TARA, are the initial group of the research centers to besupported by the Organization, which aims to expand horizontally among these centers thetasks/achievements of promoting advanced /interdisciplinary researches, internationalization, strategic PI
recruitment, and reforming systems thus far headed by IIIS. Upon completion of IIIS as a WPI-supporting
center, the University has decided to create a higher rank in the Advance Research Center group as RS(Word Top Level Center), and IIIS is acknowledged to apply for the highest rank after FY2022.

6. Plan for Sustaining the WPI Brand* Describe your plan for sustaining and enhancing the WPI brand.

IIIS has been established de novo in University of Tsukuba as the WPI Center focusing basic sleep science
to solve the medical and social issues related to sleep by elucidating mechanisms of sleep/wake regulationand molecular pathogenesis of sleep disorders, and developing treatments for sleep disorders. By FY2020,
the research focus expands to another hypomobile state, hibernation, with a discovery of Q neurons,
exploited by the Vice Director’s research team. After 10 years based on achievement by all IIIS members
and their collaborators, IIIS have successfully elaborated a “world premier” status, resulting in the best
fruit of the WPI Program. IIIS positions now itself as a world leader in sleep, and colleagues in the related
field well recognize domestically and internationally IIIS launched as one of WPI Centers that MEXT, Japan
initiated a while ago.
One of success points in domestic activities must be derived from proactive participation in outreach
events. Especially, the Center Director Yanagisawa rarely declines any offers by scientific communities aswell as general media to promote IIIS/WPI Program. He will continuously draw attentions after IIIS
becomes a part of WPI Academy. Meanwhile, IIIS has attracted many school students. We have

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IIISoccasionally accepted official school visits and unofficial interviews by high-school students; among thema few applied for University of Tsukuba. Hopefully, such recruitment will increase the values of the WPI
brand. Further, IIIS members are very much encouraged to organize WPI-joint symposia and workshops
at academic organizations, e.g., Japan Society of Sleep Research. We continuously advocate WPI whenever
IIIS members conduct or are invited to events and ceremonies.
Similarly to the domestic activity, IIIS members are eager to reinforce international communication when
the pandemic of COVID-19 terminates. Several members have already committed to chair symposia at theWorld Sleep Congress in Rome, in March 2022; however most of us would not enable to travel there.
Sooner, the opportunity to integrate globally will open. Then, young members of IIIS will apply for the
next career globally through the network of IIIS alumni. In this way, WPI-IIIS members will occupy
international positions, consequently spreading out the unique reputation of WPI over the world.

7. Support by Host institution* Describe measures that the host institution will take to support and sustain your Center.

To make the foundation of IIIS sustainable, the President of University of Tsukuba has repeatedly statedat the WPI Program Committee that PIs with a proven track record of achievement should be promoted
to receive the status of ‘tenure.’ In FY2021, President Nagata initiated strategic positioning for IIIS faculty
members and offered the tenure to 4 PIs. After the termination of the supporting period of the WPI
program in FY2022, 2 PIs of IIIS will undergo a review process for a tenure position, then yearly the restof PIs will follow the same procedure.
In addition, University of Tsukuba provides IIIS various resources for operational and financial supports.
The amount would be equal to or greater than one we received in previous years;
1. IIIS receives total ¥21 M for management expenses every year as the support from Organization for
Development of Global Centers and Organization for the Support and Development of Strategic
Initiatives, respectively.
2. The Department of Research Promotion, as a counterpart in the University headquarters to IIIS,
supports various office procedures including the applications for competitive funding.
3. IIIS rents for ¥70 M/year the part of the IIIS Building (2,000 m2) owned by the University, while theUniversity bears nearly ¥90 M of utility/maintaining costs for the IIIS Building.
4. The University let IIIS use the research spaces (211 m2) in Innovation Medical Research Institute ata minimal cost to accommodate the Human Sleep Lab.

8. Resource Allocation Plan

* Describe your plans over a 5-year period for allocating resources acquired from both the host institution (e.g., financial resources andpositions) and from external research funding to execute the Center’s functions and activities described above.
* In Appendix 4, enter concrete numbers in the Resource Allocation Plan.

Financial resource and positions acquired from the host institution and their allocation are described in aprevious section and in Appendix 4. Funds from external sources are also listed in Appendix 4.
Towards the end of WPI in FY 2021, we sought large-scale and long-term competitive funding during FY
2020. Eventually our research proposal aiming to solve mysteries of sleep and hibernation that involves all
research groups in IIIS was successfully accepted by AMED as one of Moonshot-type R&D projects.
Given this prominent award, we are tremendously encouraged to further develop our research programs
without downsizing the scale of IIIS founded by the WPI support. In FY2021, the total amount of thecompetitive funds would be ¥1,089 M, of which ¥289 M was supplied from the Moonshot. Expecting afurther expansion from the financial viewpoint, the headquarter of University of Tsukuba will create a higher
position, RS (R Supreme) for assimilating IIIS into the organization of the Advance Research Centersand support IIIS more than ever by proper positioning and management expenses.
It is also worth mentioning that IIIS PIs and even non-PI junior researchers are strongly encouraged toseek KAKENHI and very active to submit proposals to different categories. We are proud that our results
opened in last April marked over 40% success rate for the FY 2021 screening. Remarkably, one of T.
Sakurai’s proposals was accepted to the Scientific Research (KIBAN) S scaled up from the A category.
Additionally, junior PIs are also accustomed to applying for project grants funded by public agencies suchas JST and AMED and private foundations. Good examples are recent acquisition of 3 awards with KAKENHI
Transformative Research Area B and 2 awards with JST FOREST, which is an excellent record representativeof University of Tsukuba. In these manners, each member will make a full effort on winning own funding
to contribute to IIIS functions and individual activities. In other words, IIIS is a very challenging cohort ofscientists seeking competitive external funding opportunities to sustain our research programs successfully.

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Appendix 1

Appendix 1 List of Principal Investigators (Application for Academy Center Certification)* If the number of principal investigators exceeds 10, add rows as appropriate.
* Give age as of 1 April 2022
* For investigators who cannot participate in the center project from FY 2022, indicate the time that their participation will start in the “Notes” column.
* Enter the host institution name and the center name in the footer.

Name

Age

1 Masashi Yanagisawa

61

2 Takeshi Sakurai

57

3 Hiromasa Funato

52

4 Robert Greene71

Current affiliation(position title, organization, department)

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba
Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba;
Professor, Faculty of Medicine,
University of Tsukuba
Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba
Professor, Toho University
Professor, Department of
Psychiatry, University of Texas
Southwestern Medical Center

5 Qinghua Liu

50

National Institute of Biological
Sciences (NIBS), Tsinghua
University, China

6 Noriki Kutsumura

44

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba

68

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba

7 Kumpei Tokuyama

Academic degree andcurrent specialties

Notes(Enter “new” or “ongoing”)

Effort(%)*

M.D., Ph.D.;
Neuroscience,
Pharmacology

95

ongoing

M.D., Ph.D.;
Neuroscience80

ongoing

M.D., Ph.D.;
Neuroscience40

ongoing

M.D., Ph.D.;
Neuroscience10

ongoing10

ongoing80

ongoing100

ongoing

Ph.D. ;
Genetics,
Molecular Biology,
Biochemistry
Ph.D.; Organic
Chemistry, Medicinal
Chemistry
Ph.D., ; Energy
Metabolims

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Appendix 1

8 Takashi Kanbayashi

58

9 Michael Lazarus

52

10 Kaspar Vogt

55

11 Masanori Sakaguchi

45

12 Yu Hayashi

41

13 Takashi Abe

42

14 Sakiko Honjoh

41

15 Yo Oishi

41

16 Katsuyasu Sakurai

43

17 Arisa Hirano

36

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba;
Physician, Ibaraki Prefectural
Medical Center of Psychiatry
Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba

M.D., Ph.D.; Sleep
Medicine andPsychiatry

80

ongoing

Ph.D.; Neuroscience80

ongoing100

ongoing80

ongoing20

ongoing100

ongoing

Ph.D.;
Molecular biology,
Genetics, Neuroscience100

ongoing

Ph.D.; Neuroscience80

ongoing

Ph.D.; Neuroscience100

ongoing

Ph.D.;
Molecular biology,
Genetics, Neuroscience80

ongoing

M.D., Ph.D.;
Associate Professor, International
Physiology,
Institute for Integrative Sleep
Pharmacology,
Medicine, University of Tsukuba
Neurobiology
Associate Professor, International
M.D., Ph.D.;
Institute for Integrative Sleep
Neuroscience
Medicine, University of Tsukuba
Professor (WPI-IIIS), International
Institute for Integrative Sleep
Medicine, University of Tsukuba
Ph.D.; Neuroscience
Professor, Graduate School of
Medicine, Kyoto University
Associate Professor, International Ph.D.;
Institute for Integrative Sleep
Behavioral Science
Medicine, University of Tsukuba
Psychophysiology
Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba
Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba
Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba
Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba;
Assistant Professor, Faculty of
Medicine, University of Tsukuba

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Appendix 1

18 Hirofumi Toda

19 Hiroyuki Kitagawa

20 Shoi Shi

21 Tsuyoshi Saito

22 Mayumi Kimura

43

Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba

Ph.D.; Genetics

100

ongoing

66

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba

Ph.D.; Computer
Science, Databases,
Big Data

100

ongoing

34

Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba

Ph.D.; Neuroscience

100

new

37

Assistant Professor, International
Institute for Integrative Sleep
Medicine, University of Tsukuba

Ph.D.;
Medicinal Chemistry,
Chemical Biology

100

new

61

Professor, International Institutefor Integrative Sleep Medicine,
University of Tsukuba

Ph.D.; Physiology,
Neuroscience

100

new

10

ongoing (Satellite)10

new (Satellite)10

new (Satellite)10

new (Satellite)10

new (Satellite)10

new (Satellite)

23 Tomohiro Okura

49

24 Toshiyuki Amagasa

50

25 Masayuki Matsumoto

45

26 Haruka Ozaki

34

27 Clifford B. Saper

70

28 Vladyslav Vyazovskiy

46

Ph.D.; Exercise
Professor, Faculty of Health andPrescription, Exercise
Sport Sciences, University of
Epidemiology,
TsukubaGerontological Healthand Fitness
Professor,
Ph.D.; Computer
Center for Computational Sciences, Science, Databases,
University of Tsukuba
Big Data
Professor, Faculty of Medicine,
University of Tsukuba

Ph.D.;
Neurophysiology,
General Neuroscience

Associate Professor, Bioinformatics
Ph.D.; Computational
Laboratory, Faculty of Medicine,
Biology
University of Tsukuba
Professor, Neurology and
M.D., Ph.D. ;Neuroscience, Harvard Medical
Neurobiology,
SchoolCircadian Rhythms
Professor, Dep Physiology,
Ph.D.; Sleep
Anatomy and Genetics, Oxford
Physiology
University

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Appendix 1

29 Hiroyasu Ando

43

Professor, Center of Mathematical
Ph.D.; Medical
Sciences for Open Innovation,
Informatics
Tohoku University

30 Genshiro Sunagawa

45

Senior Research Scientist, Center
for Biosystems Dynamics
Research, RIKEN

M.D., Ph.D.;
Physiology,
Emergency Medicine

10

new (Satellite)

50

Professor, Research Institute ofEnvironmental Medicine, Nagoya
University

Ph.D.;
Neurophysiology,
Electrophysiology,
Molecular Biology

10

new (Satellite)

48

Professor, Faculty of Economics,
Keio University

Ph.D; Microeconomics,
Game Theory,
Matching Market
Design, Experimental
Economics

10

new (Satellite)

60

President & CEO, S’UIMIN Inc.
DVM; Entrepreneur,
Visiting Investigator, International
Executive, Sleep
Institute for Integrative Sleep
Measurement
Medicine, University of Tsukuba10

new (Satellite)

31 Akihiro Yamanaka

32 Moriyasu Kurino

33 Masaaki Fujiwara

10

new (Satellite)*Percentage of time that the principal investigator devotes to working for the center vis-à-vis his/her total working hours.

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Appendix 2

World Premier International Research Center Initiative (WPI)
Number of Center Personnel
FY2022
Number of persons

Researchers％

68

Overseas researchers

25

36.8

Female researchers

26

38.2

Principal investigators (PIs)

22

Overseas PIs

6

27.3

Female PIs

3

13.6

Other researchers

12

Overseas researchers

2

16.7

Female researchers

4

33.3

Postdocs

34

Overseas Postdocs

1750

Female Postdocs

19

55.9

Research support staffs

82

Administrative staffs

20

TOTAL

170
University of Tsukuba

IIISAppendix 3

World Premier International Research Center Initiative (WPI)
Diagram of Organizational Management System- Diagram the Center’s organizational management system and its position within the host institution in an easily understood manner.

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