COINS Seminar #9" Implantable Optical Biosensors –Materials and Instrumentation for NextGeneration Monitoring"
Prof. Michael J. McShane
Texas A&M University, U. S. A.
Date: June 29, 2015
Time: 4pm ~ 5pm
Venue: #3001, Innovation Center of Nanomedicine (iCONM)(See access map to next page)
Capacity: 40 people
Application: By E-mail (jimukyoku-coins@kawasaki-net.ne.jp)
Please send your “name” and “Affiliation”—Abstract—
Personal health monitoring is becoming increasingly accessible. The ease ofproducing low-cost, low-power embedded systems has fueled a rapid growth in consumer products aimed at“measuring me.” Common examples include activity trackers, pulse and heart rate monitors, and sleep
assessment tools. While new products are released regularly, a major technology gap is in the space ofcontinuous chemical sensing. Commercial devices for continuous glucose monitoring are examples ofprogress in this area; yet, they are invasive and lack longevity. Fully implantable or completely

noninvasive systems face significant hurdles to implementation. Our research is focused on developing
miniature, injectable, “passive” biosensor implants with microscale and nanoscale organization to enable
observation of interstitial biochemistry. These materials provide specificity through use of specific receptors
and enhance sensitivity through optical amplification, and they employ materials that can integrate
naturally with tissue, such as porous gels and microparticle suspensions. While aimed primarily toward thelong-term goal of personal health monitoring, these systems may provide opportunities for advanced basic
research as well as potential clinical applications. Towards this goal, with an emphasis on monitoring ofdiabetes and other chronic conditions, we have demonstrated hydrogel-based biochemical sensors thatchange optical properties as measured by luminescence intensity and lifetime or Raman scattering. Thistalk will describe several examples of these materials and the under-lying motivation for their design,

particularly highlighting the major challenges to long-term monitoring. To conclude the talk, recent in vivo

observations revealing interesting apparent physiological changes will be presented. The data illustrate thefeasibility of this approach, but also open new questions and new ideas about the value of collecting
chemical information continuously.
＊Organizer: Center of Innovation (COI program) by JST
Kazunori Kataoka, Research Leader, Kawasaki Institute of Industrial Promotion, Innovation Center of Nanomedicine (iCONM)
and Professor. Graduate Schools of Engineering / Medicine, The University of Tokyo＊For Further Information Contact: COINS Research Support Office E-mail: jimukyoku-coins@kawasaki-net.ne.jp
Web: http://coins.kawasaki-net.ne.jp

＜Venue access＞
Name: Innovation Center of Nanomedicine (iCONM)
Address: 3-25-14, Tonomachi, Kawasaki-ku, Kawasaki 210-0821, JAPANAccess by train:
Keikyu-Kawasaki Sta. to Kojima-Shinden Sta. by Keikyu-Daishi Line (ride time about 10minutes) and Walk about 15 minutes to iCONM (See below access map)
Access by bus“Bus stop on East Terminal at JR Kawasaki Sta.”
1) No. 20 bus stop (KAWASAKI TSURUMI RINKO BUS Co.,LTD）
川 (kawa) 02 line; Tonomachi terminal, to “Tonomachi” bus stop (ride time about 30minutes), walk about 3 minutes to iCONM from the BS
2) No. 20 bus stop (KAWASAKI TSURUMI RINKO BUS Co.,LTD）
川 (kawa) 02 line; Ukishima-Bashi terminal, to “King Sky Front Irigchi” (ride time about 20minutes), walk about 5 minutes to iCONM from the BS3) No. 16 bus stop (KAWASAKI TSURUMI RINKO BUS Co.,LTD）
川 (kawa) 03 line; Ukishima-bus terminal, to “King Sky Front Irigchi” (ride time about 30minutes), walk about 5 minutes to iCONM from the BSAccess Map

Innovation Center of Nanomedicine（iCONM）