㻌㻌≉ูㅮ₇せ᪨㻌㻌䠕᭶䠍䠍᪥䠄ᮌ䠅㻌
1S01㻌 A ఍ሙ㻌㻌䠕᭶䠍䠎᪥䠄㔠䠅㻌
2S01㻌 A ఍ሙ㻌
㻌

1S01

᰾་Ꮫ᳨ᰝཬࡧ἞⒪ࡢ᭱๓⥺ྡ኱㝔་ ‫ۑ‬ຍ⸨ඞᙪ

᰾་Ꮫ㸦Nuclear medicine㸧ࡣ࡜ࡶࡍࢀࡤ Unclear medicine ࡞࡝࡜᥾ᥟࡉࢀࡓࡾࡍࡿࡀࠊ࠺ࡲࡃ฼⏝ࡍࢀࡤࠊCTࠊMRIࠊ㉸㡢Ἴ࡞࡝ࡢ௚ࡢ⏬ീデ᩿࡟ࡲࡉࡿ࡜ࡶຎࡽ࡞࠸ጾຊࢆⓎ᥹ࡍࡿࠋPET/CT ࡸ SPECT/CT ࡢⓏሙ௨᮶ࡑࡢ฼⏝㢖ᗘࢆぢ࡚ࡶ᫂ࡽ࠿࡛࠶ࡿࡀࠊࡑࢀ௨እࡢྂ࠸᰾་Ꮫ᳨ᰝ࡛ࡶ▱ࡗ࡚ࡉ࠼࠸ࢀࡤ㠀ᖖ࡟ᙺ❧ࡘሙྜࡀ࠶ࡿࠋࡇࡢㅮ₇࡛ࡣࠕ᰾་Ꮫ᳨ᰝཬࡧ἞⒪ࡢ᭱๓⥺ࠖࢆᐇ㝿ࡢ⑕౛ࢆ஺࠼࡞ࡀࡽᴫㄝࡍࡿࠋ᰾་Ꮫ᳨ᰝཬࡧ἞⒪ࡢ᭷⏝ᛶࢆ▱ࡗ࡚࠸ࡓࡔࡅࢀࡤᖾ࠸࡛࠶ࡿࠋ ᰾་Ꮫ᳨ᰝ࡟ࡣࡍ࡭࡚ࡢ⮚ჾ࡟ᑐࡋ࡚ࡑࢀࡒࢀ᳨ᰝࡀ࠶ࡾࠊࡍ࡭࡚ࡢ᳨ᰝࡢゎㄝࢆࡍࡿࡇ࡜ࡣ᫬㛫ไ㝈ࡀ࠶ࡾࠊ㞴ࡋ࠸ࡀࠊ௒ᅇࡢㅮ₇࡛ࡣࠊ⭘⒆ࠊ⬻ࠊᚰ⮚ࡢ᳨ᰝࢆ୰ᚰ࡟≉࡟⭘⒆
᰾་Ꮫ࡟ࡘ࠸࡚ᴫㄝࡍࡿࠋ ᰾་Ꮫ࡟ࡼࡿ⒴ࡢデ᩿࡟ࡣࠊ௚ࡢ᳨ᰝ࡟࡞࠸≉ᚩࡀ࠶ࡾࠊᵝࠎ࡞⮫ᗋࡢ⌧ሙ࡛฼⏝ࡉࢀ࡚࠸ࡿࠋ≉࡟ PET ᳨ᰝࡣࠊ2002 ᖺ 4 ᭶࠿ࡽ 12 ⑌ᝈ㸦࡚ࢇ࠿ࢇࠊ⹫⾑ᛶᚰ⑌ᝈࠊ⫵⒴ࠊங⒴ࠊ
኱⭠⒴ࠊ㢌㢁㒊⒴ࠊ⬻⭘⒆ࠊ⮅⒴ࠊᝏᛶࣜࣥࣃ⭘ࠊ㌿⛣ᛶ⫢⒴ࠊཎⓎ୙᫂⒴ࠊᝏᛶ㯮Ⰽ⭘㸧ࠊ
2006 ᖺ 4 ᭶࠿ࡽࡉࡽ࡟ 3 ⑌ᝈ㸦㣗㐨⒴ࠊᏊᐑ⒴ࠊ༸ᕢ⒴㸧ࡢಖ㝤㐺ᛂࡀㄆࡵࡽࢀ࡚࠿ࡽᛴ㏿࡟ᬑཬࡋࠊ⒴デ⒪ࡢ኱ࡁ࡞ᰕࡢ୍ࡘ࡟࡞ࡗࡓࠋ2006 ᖺ 4 ᭶࠿ࡽ PET/CT 㸦PET ⿦⨨࡟࣐ࣝࢳࢫࣛ࢖ࢫ CT ⿦⨨ࡀ୍య໬ࡉࢀࡓࡶࡢ㸧࡜ࡋ࡚ࡶಖ㝤㐺ᛂࡀㄆࡵࡽࢀࠊPET ࠾ࡼࡧ PET/CT ࡣ௒ࡸ་⒪ࡢୡ⏺࡟࠾࠸࡚࡞ࡃ࡚ࡣ࡞ࡽ࡞࠸Ꮡᅾ࡟࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ2005 ᖺ⛅ࡼࡾ 18F-FDG㸦ࣇࣝ࢜ࣟࢹ࢜࢟ࢩࢢࣝࢥ࣮ࢫ㸧ࡢၟᴗ㓄⤥࡟ࡼࡾࠊPET ࣓࢝ࣛࡢࡳࢆᣢࡗ࡚࠸ࡿ᪋タ࡛ࡶಖ㝤㐺ᛂࡀㄆࡵࡽࢀࡼ࠺࡟࡞ࡗ࡚࠸ࡿࠋಖ㝤㐺ᛂࡣ࡞࠸ࡀࡇࡢ 18F-FDG PET ࡸ PET/CT ࡛⒴᳨デ㸦⮬⏤デ⒪㸧ࢆࡋ࡚࠸ࡿ⑓㝔ࡸࢡࣜࢽࢵࢡࡶከࡃࡳࡽࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁ࡚࠸ࡿࠋ2010ᖺ 4 ᭶࠿ࡽࡣデ⒪ሗ㓘ࡢᨵᐃ࡟ࡼࡾࠊPET ࠾ࡼࡧ PET/CT ࡣᝏᛶ⭘⒆㸦᪩ᮇ⫶⒴ࢆ㝖ࡃ㸧ࡢ⑓ᮇデ᩿ࡲࡓࡣ㌿⛣࣭෌Ⓨデ᩿࡟ಖ㝤㐺⏝ࡉࢀࡓࡢ࡛ࠊࡉࡽ࡟᳨ᰝࡢᩘࡀቑ࠼࡚࠸ࡿࠋ2012ᖺ 4 ᭶࠿ࡽࡣᚰࢧࣝࢥ࢖ࢻ࣮ࢩࢫ࡟࠾ࡅࡿ⅖⑕㒊఩ࡢデ᩿ࡀᚲせ࡜ࡉࢀࡿᝈ⪅ࡸᝏᛶࣜࣥࣃ
⭘ࡢ἞⒪ຠᯝุᐃࡀ㏣ຍࡉࢀࡓࠋ ᰾་Ꮫ࡟ࡼࡿデ᩿ࡣ࠺ࡲࡃ฼⏝ࡍࢀࡤ㠀ᖖ࡟ጾຊࢆⓎ᥹ࡍࡿࠋᝏᛶ⭘⒆ࡢデ᩿ࡸ⑓ᮇศ㢮ࡢࡓࡵࡤ࠿ࡾ࡛࡞ࡃࠊ἞⒪᪉㔪ࢆỴᐃࡍࡿ㝿㸦ᡭ⾡ࠊᨺᑕ⥺἞⒪ࠊ໬Ꮫ⒪ἲ࡞࡝㸧ࡸࠊ෌Ⓨ㌿⛣ࡢデ᩿࡟ࡶ኱ࡁ࡞㔜せ࡞ᙺ┠ࢆᯝࡓࡋ࡚࠸ࡿࠋᨺᑕ⥺἞⒪ࡢࣉࣛࣥࢽࣥࢢ࡟ࡶ㔜せ࡞ᙺ┠ࢆᯝࡓࡋࠊ⬻⾑ὶ᳨ᰝ࡛ࡣㄆ▱⑕ࠊ⬻⾑⟶㞀ᐖ➼ࡢデ᩿࡟㔜せ࡞ᙺ┠ࢆᯝࡓࡍࠋࡲࡓ⹫⾑ᛶᚰ⑌ᝈࡢࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡶ㔜せ࡞ᙺ┠ࢆᯝࡓࡋ࡚࠸ࡿࠋ ᰾་Ꮫ἞⒪࡛ࡣࠊ⏥≧⭢⒴ࠊ⏥≧⭢ᶵ⬟ஹ㐍⑕࡟࠾ࡅࡿ 131I ෆ⏝⒪ἲࡣ 50 ᖺ௨ୖࡢṔྐࡀ࠶ࡿ㠀ᖖ࡟᭷ຠ࡞἞⒪ἲ࡛࠶ࡿࠋ㌿⛣ᛶ㦵⭘⒆⑊③⦆࿴࡟฼⏝ࡉࢀࡿ 89Sr㸦࣓ࢱࢫࢺࣟࣥ㸧࡟ࡼࡿෆ⏝⒪ἲࠊ B ⣽⬊ᛶ㠀࣍ࢪ࢟ࣥࣜࣥࣃ⭘࡟ᑐࡍࡿ 90Y㸦ࢮࣦ࢓ࣜࣥ㸧࡟ࡼࡿෆ⏝⒪ἲࠊ
๓❧⭢⒴࡟ᑐࡍࡿ 125I-seeds㸦OncoSeed㸧࡟ࡼࡿᑠ⥺※἞⒪ࡀ᪥ᮏ࡛ࡣಖ㝤㐺ᛂ࡟࡞ࡗ࡚࠸ࡿࠋࡉࡽ࡟ࠊಖ㝤㐺ᛂࡣ࡞࠸ࡀ⚄⤒ⱆ⣽⬊⭘ࡸ〓Ⰽ⣽⬊⭘࡟ᑐࡍࡿ 131I-MIBG ෆ⏝⒪ἲࠊ⬻⭘⒆ࡸᝏᛶ㯮Ⰽ⭘࡟ᑐࡍࡿ࣍࢘⣲୰ᛶᏊᤕᤊ⒪ἲ (Boron neutron capture therapy: BNCT)ࠊ⚄⤒ෆศἪ⭘⒆࡟ᑐࡍࡿ 177Lu-octreotateࠊ㌿⛣ᛶ㦵⭘⒆⑊③⦆࿴࡟ᑐࡍࡿ 153Sm-EDTMP㸦Quadramet㸧ࠊ
223
Ra㸦Xofigo㸧➼ࡀᅜෆእ࡛⾜ࢃࢀ࡚࠸ࡿࠋ᫬㛫ࡀチࡏࡤࡑࢀࡽ࡟ࡘ࠸࡚ࡶ㏙࡭ࡿࠋ
The forefront of diagnostic imaging and therapies in nuclear medicine
KATO, K.

- 25 -ᮏㅮ₇࡛ࡣࠊ᰾་Ꮫ࡟ࡼࡿデ᩿ࠊ἞⒪ࡢ᭷ຠᛶࢆ♧ࡋࠊࡼࡾࡼ࠸་⒪ࢆ⾜࠺ࡓࡵ࡟࠸࠿࡟᰾་Ꮫࢆ฼⏝ࡍ࡭ࡁ࠿࡟ࡘ࠸࡚ゎㄝࡍࡿࠋ PET ࡜࠸࠺࡜᭱㏆࡛ࡣ 18F-FDG PET ࢆᣦࡍࡇ࡜ࡀከ࠸ࡀࠊ⢾ࡢ௦ㅰࢆࡳࡿ 18F-FDG PET ࡛
ࡣ⅖⑕ࡸⰋᛶ⭘⒆࡟ࡶ㞟✚ࡍࡿࡇ࡜ࡶᑡ࡞ࡃ࡞࠸ࠋᐇ㝿ࡢデ⒪ࡢ⌧ሙ࡛ࡣࠊ18F-FDG PET ࡸPET/CT ࡢࡳ࠿ࡽࡣデ᩿ࡀࡘ࠿࡞࠸ࡇ࡜ࡶከࡃ࠶ࡿࠋ18F-FDG PET ࡸ PET/CT ᳨ᰝ࡟ᑐࡍࡿࡼࡃ࠶ࡿㄗゎࡸ㝈⏺࡟ࡘ࠸࡚ࡶ㏙࡭ࡿࠋྡ኱⑓㝔࡛ࡣࠊᚑ᮶࠿ࡽ⾜ࡗ࡚࠸ࡿ 18F-FDG ௨እ࡟ࡶࠊ11C-࣓ࢳ࢜ࢽࣥࠊ 11C-ࢥࣜࣥࠊ 18F-FDOPAࠊ 18F-FACBC (18F-NMK36)ࠊ 18F- fluorideࠊ 18F- FLT(fluorothymidine)࡞࡝ࢆ౑ࡗࡓ PET ࠾ࡼࡧ PET/CT ᳨ᰝࡶ⾜ࡗ࡚࠸ࡿࡀࠊ᫬㛫ࡀチࡏࡤࡑࢀࡽ࡟ࡘ࠸࡚ࡶゎㄝࡍࡿࠋ SPECT ᳨ᰝ࡛ࡣࠊ201Tlࠊ67Gaࠊ123I-MIBG (meta-iodobenzylguanidine)ࠊ131I-MIBGࠊ131I-࢔ࢻࢫࢸ ࣟ ࣮ ࣝ ࠊ 123I-IMP (N-isopropyl-p-123I-iodoamphetamine) ࠊ 99mTc-HMPAO (99mTc-hexamethylprophylene amine oxime)ࠊ99mTc-ECD (99mTc-ethyl cysteinate dimer)ࠊ99mTc-MIBI (methoxyisobutylisonitrile)ࠊ99mTc-MDP (methylenediphosphonate)ࠊ99mTc-HMDP (hydroxymethylenediphosphonate)➼ࢆ౑ࡗࡓ SPECTࠊSPECT/CT ᳨ᰝ࡟ࡘ࠸࡚ゎㄝࡍࡿࠋ- 26 -

2S01኱ᙉᗘ㝧Ꮚຍ㏿ჾ᪋タ -3$5&࡟࠾ࡅࡿᨺᑕ໬Ꮫ◊✲ᅜ㝿ᇶ╩ᩍ኱ ‫ஂۑ‬ಖㅬဢJ-PARC (Japan Proton Accelerator Research Complex. ཧ↷ http://j-parc.jp)ࡣࠊ⣲⢏Ꮚ≀⌮ࠊཎᏊ᰾≀⌮ࠊ≀㉁⛉Ꮫࠊ⏕࿨⛉ᏛࠊཎᏊຊ࡞࡝ᖜᗈ࠸ศ㔝ࡢ᭱ඛ➃◊✲ࢆ⾜࠺ࡓࡵࡢ㝧Ꮚຍ㏿ჾ⩌࡜ᐇ㦂᪋タ⩌ࡢ࿧⛠࡛࠶ࡿࠋJ-PARC ࡢ᭱኱ࡢ≉ᚩࡣࠊ1 MW(┠ᶆࠋ3 GeV ࡢ㝧Ꮚࣅ࣮࣒࡛ 333 !A)࡜࠸࠺ୡ⏺᭱㧗ࢡࣛࢫࡢ㝧Ꮚࣅ࣮࣒࠿ࡽ⏕ᡂࡍࡿ୰ᛶᏊࠊ࣑ࣗ࢜ࣥࠊK ୰㛫Ꮚࠊࢽ࣮ࣗࢺࣜࣀ࡞࡝஧ḟ⢏Ꮚࣅ࣮࣒ࢆ฼⏝ࡋࡓ◊✲ࡀ࡛ࡁࡿࡇ࡜࡟࠶ࡿࠋ㧗࢚ࢿࣝࢠ࣮ຍ㏿ჾ◊✲ᶵᵓ(KEK)࡜᪥ᮏཎᏊຊ◊✲㛤Ⓨᶵᵓ(JAEA)ࡢ༠ຊ࡟ࡼࡾࠊ2008 ᖺ࡟ᮾᾏࡢཎᏊຊ⛉Ꮫ◊✲ᡤෆ࡟➨୍ᮇ᪋タࡀ᏶ᡂࡋࡓࠋึࣅ࣮࣒᫬ࡢ 20 kW ࠿ࡽḟ➨࡟ࣅ࣮࣒ᙉᗘࢆୖࡆࠊ2011 ᖺࡢᮾ᪥ᮏ኱㟈⅏࡟ࡼࡗ࡚୰᩿ࢆవ൤࡞ࡃࡉࢀࡓࡀࠊ௒⛅࠿ࡽࡣ 500 kW ࣅ࣮࣒㐠㌿ࡀணᐃࡉࢀ࡚࠸ࡿࠋ᪋タࡢ୰࡛ࡶ≀㉁࣭⏕࿨⛉Ꮫ◊✲᪋タ(MLF: Materials and Life Science Experimental Facility)࡛ࡣࠊ㧗ᙉᗘࡢ࣑ࣗ࢜ࣥ࡜୰ᛶᏊࣅ࣮࣒ࢆ฼⏝ࡋࡓ◊✲᪋タ࡛ࠊ࣑ࣗ࢜ࣥ᪋タࡣ⌧ᅾ 2 ࣏࣮ࢺࠊ୰ᛶᏊ᪋タࡣ 24 ࡢࣅ࣮࣒࣏࣮ࢺࡀ࠶ࡾࠊከࡃࡢ◊✲ㄢ㢟ࡀᖹ⾜ࡋ࡚ᐇ᪋ࡉࢀ࡚࠸ࡿࠋ࣑ࣗ࢜ࣥ⛉Ꮫ◊✲᪋タ(MUSE: MUon Science Establishment)࡛ࡣࠊ3 GeV 㝧Ꮚࢆ㯮㖄ࢱ࣮ࢤࢵࢺ࡟↷ᑕࡋ࡚"⢏Ꮚࢆసࡾࠊࡑࢀࡀቯኚࡋ࡚࡛ࡁࡿୡ⏺᭱㧗ᙉᗘࡢ࣑ࣗ࢜ࣥࣅ࣮࣒ࢆ฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ≀㉁⛉Ꮫࡢࣘࢽ࣮ࢡ࡞◊✲ᡭἲ࡛࠶ࡿ!SR ἲ࡛≀㉁⛉Ꮫ◊✲ࡀ⾜ࢃࢀࡿ࡜࡜ࡶ࡟ࠊ᭱㏆࡛ࡣ೵Ṇࡋࡓ࣑ࣗ࢜ࣥࢆ෌ຍ㏿ࡋ࡚௵ពࡢ㐠ື࢚ࢿࣝࢠ࣮ࢆࡶࡗࡓ࣑ࣗ࢜ࣥࣅ࣮࣒ࢆ⏕ᡂࡋ࡚࣑ࣗ࢜ࣥࡢᛂ⏝⠊ᅖࢆ㣕㌍ⓗ࡟ᣑ኱ࡍࡿ㉸ప㏿࣑࣏࣮ࣗ࢜ࣥࢺࡢᘓタࡀ⾜ࢃࢀ࡚࠸ࡿࠋࡲࡓ࣑ࣗ࢜ࣥࢆ฼⏝ࡋࡓ኱つᶍ⣲⢏Ꮚ≀⌮ᐇ㦂ࡸཎᏊ≀⌮ࡢࡓࡵࡢ㛤Ⓨ◊✲ࡶ┒ࢇ࡛࠶ࡿࠋ໬Ꮫ⪅ࡣከࡃࡣ࡞࠸ࡀࠊ࣑ࣗ࢜ࣥ X ⥺ࢆ฼⏝ࡋࡓ㠀◚ቯඖ⣲ศᯒࡸ!SR ◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿࠋ୰ᛶᏊ᪋タ࡛ࡣࠊ㝧Ꮚࣅ࣮࣒ࢆỈ㖟ࢱ࣮ࢤࢵࢺ࡟↷ᑕࡍࡿࡇ࡜࡟ࡼࡾ᰾◚○୰ᛶᏊࢆⓎ⏕ࡉࡏ࡚࠸ࡿࠋ㧗㏿ࡢ୰ᛶᏊ࠿ࡽప Ỉ⣲࡛෭༷ࡍࡿࡇ࡜࡟ࡼࡾ㉸ప ୰ᛶᏊࡲ࡛ᗈ࠸࢚ࢿࣝࢠ࣮⠊ᅖࢆࡶࡘ୰ᛶᏊࣅ࣮࣒ࢆ฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋከࡃࡣ୰ᛶᏊᩓ஘ᐇ㦂࣏࣮ࢺ࡛࠶ࡗ࡚㧗ᅽࡸప ࡞࡝ᗈ࠸ヨᩱ⎔ቃ࡛◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿࠋ≉࡟Ỉ⣲ࡀ኱ࡁ࡞୰ᛶᏊᩓ஘᣺ᖜࢆᣢࡘࡇ࡜ࢆ฼⏝ࡋ࡚ࠊX ⥺ᅇᢡ࡛ࡣ ᐃࡀᅔ㞴࡞⤖ᬗ୰ࡢỈ⣲఩⨨ࡢゎ᫂࡟ࡣ኱ࡁ࡞ጾຊࢆⓎ᥹ࡋࠊ㓝⣲࡞࡝ࡢ⏕య≀㉁ࡢ◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿࠋ୰ᛶᏊ᪋タࡢ 4 ␒࣏࣮ࢺࡣ
ANNRI( Accurate Neutron-Nucleus Reaction measurement Instrument)࡜ྡ௜ࡅࡽࢀࠊከᩘࡢ Ge ᳨ฟჾࢆ㓄⨨ࡋࡓ᰾ศග⿦⨨࡛࠶ࡿࡀࠊ୰ᛶᏊࣅ࣮࣒ࢆ⏝࠸ࡓ༶Ⓨ#⥺ศᯒࡀྍ⬟࡛࠶ࡿࠋᚑ᮶⾜ࢃࢀ࡚ࡁࡓཎᏊ⅔୰ᛶᏊࡸཎᏊ⅔୰ᛶᏊࣅ࣮࣒࡜ࡣ␗࡞ࡿ≉ᚩࢆᣢࡗࡓศᯒἲࡢ㛤Ⓨࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋ
₇⪅ࡣ 2008 ᖺ࠿ࡽ MUSE ࡢᘓタ࡜᪋タᩚഛ࡟㛵ࢃࡿ࡜࡜ࡶ࡟ࠊ࣑ࣗ࢜ࣥࢆ౑ࡗࡓ◊✲ࠊ≉࡟ୡ⏺ⓗ࡟ࡶ MUSE ௨እ࡛ࡣᐇ᪋ᅔ㞴࡞࣑ࣗ࢜ࣥ X ⥺࡟ࡼࡿ㠀◚ቯඖ⣲ศᯒἲࡢ㛤Ⓨࢆ⾜ࡗ࡚ࡁࡓࠋㅮ₇࡛ࡣ MLF ࢆ୰ᚰ࡜ࡋ࡚᪋タ࡜◊✲ࡢ⌧≧ࢆ⤂௓ࡍࡿࡀࠊMLF ࡢ᪋タࡢከࡃࡣ౪⏝᪋タ࡛࠶ࡾࠊࡲࡓ୍㒊ࡣ኱Ꮫඹྠ฼⏝࡜࡞ࡗ࡚࠸ࡿࠋࡇࡢୡ⏺ⓗ࡟ࣘࢽ࣮ࢡ࡞᪋タ࡟࠾࠸࡚ࠊࡍ࡛࡟⾜ࢃࢀ࡚࠸ࡿ◊✲ࢆྵࡳࡘࡘࠊࡑࢀࡽࢆ㉸࠼ࡿ᪂ࡋ࠸Ⓨ᝿࡟ᇶ࡙ࡃ◊✲ࢆ✚ᴟⓗ࡟⾜࠺ⱝேࡢཧධࢆᮇᚅࡋࠊࡑࡢ➃⥴࡜࡞ࡿࡇ࡜ࡀ࡛ࡁࢀࡤᖾ⏒࡛࠶ࡿࠋRadiochemistry at J-PARC
KUBO, M. K.

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