Plenary Lecture
September 4 (Wed) 15:00-15:50 Room A (Suisei Hall)
Chair: Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
PL-1

Interaction of mercury and selenium◯ Akira Naganuma(Tohoku University)

Educational Lecture
September 5 (Thu) 11:10-11:50 Room A (Suisei Hall)
Chair: Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
EL-1

The safety of so-called health foods as a basic knowledge for pharmacists◯ Chikako Uneyama(Natl. Inst. Health Sci.)

Award Lectures
Scientific Award
September 5 (Thu) 13:00-13:30 Room A (Suisei Hall)
Chair: Toshiyuki Kaji（Fac. Pharm. Sci., Tokyo Univ. Sci.）
AL-1

Molecular mechanisms for toxic metals-induced vascular toxicity◯ Yasuyuki Fujiwara(Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)

Kanehara Award
September 5 (Thu) 13:30-13:50 Room A (Suisei Hall)
Chair: Shogo Misumi（Grad. Sch. Pharm. Sci., Kumamoto Univ.）
AL2-1

Metabolic hijacking and the role of glycolytic enzymes in viral replication◯ Naoki Kishimoto(Grad. Sch. Pharm. Sci., Kumamoto Univ.)−51−

September 5 (Thu) 13:50-14:10 Room A (Suisei Hall)
Chair: Yaichiro Kotake（Grad. Sch. Biomed. Health Sci, Hiroshima Univ.）
AL2-2

Nutritional Functions of Polyunsaturated Fatty Acids Focusing on Drug
Metabolizing Enzymes◯ Ami Oguro(Grad. Sch. of Biomed. and Health Sci, Hiroshima Univ.)

Invited Lecture
September 4 (Wed) 12:30-13:00 Room A (Suisei Hall)
Chair: Shuntaro Hara（Sch. of Pharm., Showa Univ.）
IL-1

Development of a convenient test for determining skin sensitization potential ofchemicals in chemico◯ Tae Cheon Jeong, Rahul U. Nepal(College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea)

Forum Ⅰ : Environmental pollutants in the water and atmosphericsystems –Distribution, toxicity, and countermeasure–
September 4 (Wed) 9:00-11:00 Room A (Suisei Hall)
Organizer / Chair: Fumihiko Ogata（Fac. Pharm., Kindai Univ.）
Ken Tachibana（Fac. Pharm. Sanyo-Onoda City Univ.）
F1-1

Environmental dynamics of microplastics and nanoplastics from land to seabedand atmosphere◯ Shuhei Tanaka, Tamaki Morioka, Sachithra Imbulana(Grad. Global Env. Stu, Kyoto Univ)

F1-2

Development of standards of microplastics based on the real-world physicalproperties toward evaluation of their biological effects◯ Kazuma Higashisaka1,2,3, Hirofumi Tsujino2,3,4, Yuya Haga2,3, Yasuo Tsutsumi2,3,5,6(1IACS, Osaka Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Sch. Pharm. Sci., Osaka Univ., 4Museum Links, Osaka Univ., 5MEI Ctr., Osaka Univ.,
6
OTRI., Osaka Univ.)

−52−

F1-3

Impact of Artificial Sunlight Aging on the Respiratory Effects of Polyethylene
Terephthalate Microplastics through Degradation-Mediated Terephthalic Acid
Release◯ Yasuhiro Ishihara1, Mizuo Kajino2, Hiroshi Okochi3(1Grad. Sch. Integr. Sci. Life, Hiroshima Univ,
2
Meteorol. Res. Inst., Japan Meteorol. Agency,
3Sch. Creative Sci. Engineer., Waseda Univ.)

F1-4

Environmental contamination and human exposure to per- and polyfluoroalkyl
substances (PFAS)◯ Yukiko Fujii(Fac. Pharm. Sci., Daiichi Univ.)

Forum Ⅱ : Toxicity testing by new approach methodologies (NAMs)
September 4 (Wed) 16:00-18:00 Room A (Suisei Hall)
Organizer / Chair: Yasunari Kanda（Div. Pharmacol., NIHS）
Seigo Sanoh（Sch. Pharm. Sci., Wakayama Med. Univ.）
F2-1

Utility and future perspective of chimeric mice with humanized liver for predictionof drug metabolism, pharmacokinetics, and hepatotoxicity◯ Seigo Sanoh(Sch. Pharm. Sci., Wakayama Med. Univ.)

F2-2

Generation of small intestine-like tissue using microfluidic devices and human ES/
iPS cells◯ Sayaka Deguchi, Kazuo Takayama(CiRA, Kyoto Univ.)

F2-3

Development of machine learning models for predicting skin sensitization intensity
using New Approach Methodologies (NAMs)◯ Kaori Ambe
(Grad. Sch. Pharm. Sci., Nagoya City Univ.)

F2-4

Current status and future perspectives on NAM-based approach◯ Yasunari Kanda(NIHS)−53−

Forum Ⅲ : Lipid metabolism and biological responses associatedwith health and disease
September 5 (Thu) 9:00-11:00 Room A (Suisei Hall)
Organizer / Chair: Hirotaka Imai（Sch. Pharm. Sci., Kitasato Univ.）
Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
F3-1

Analysis of preventive effects of antibiotic cefoperazone on the cardio sudden
death by decrease of vitamin E◯ Tomoko Koumura, Narumi Watanabe, Shion Nagashima, Hirotaka Imai
(Sch. of Pharm. Sci., Kitasato Univ.)

F3-2

A comprehensive understanding of the mechanisms of actions of diverse trans fatty acid species◯ Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

F3-3

Functional analysis of long-chain acyl CoA synthetase 4 in various pathologicalconditions◯ Shuntaro Hara, Yuki Tomitsuka, Tsubasa Ochiai, Hiroshi Kuwata(Sch. Pharm., Showa Univ.)

F3-4

Homeostasis of cell membrane phospholipid fatty acid composition and cellularstress◯ Junken Aoki, Nozomu Kono
(Grad. Sch. Pharm. Sci., Univ. Tokyo)

Forum Ⅳ : Cutting-edge research on redox supramolecules andreactive species
September 5 (Thu) 14:20-16:20 Room A (Suisei Hall)
Organizer / Chair: Fan-Yan Wei (IDAC, Tohoku Univ.)
Yoshiro Saito (Grad. Sch. Pharm. Sci., Tohoku Univ.)
F4-1

Biological defense mediated by redox supramolecule “selenoprotein” and its
metabolic control◯ Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

F4-2

Elucidation of the mechanisms underlying iron-induced ferroptosis◯ Hiroaki Fujita, Kazuhiro Iwai
(Med., Kyoto Univ)

−54−

F4-3

Nitric oxide in the brain involved in age-related memory impairment◯ Ayako Tonoki(Grad. Sch. Pharm. Sci., Chiba Univ.)

F4-4

The regulation of supersulfides under chronic hypoxia◯ Hiroki Sekine(Grad. Sch. Med., Tohoku Univ.)

F4-5

RNA sulfur modification in stress response◯ Fan-Yan Wei(IDAC, Tohoku Univ.)−55−

2024 Japan/Korea Joint Symposium on Pharmaceutical Health
Science and Environmental Toxicology
September 4 (Wed) 11:30-12:30 Room A (Suisei Hall)
Chair: Kyung-Min Lim（College of Pharmacy, Ewha Womans University）
Seigo Sanoh（Sch. Pharm. Sci., Wakayama Med. Univ.）
S-1

Challenge to elucidate the mechanism of breast cancer development caused by
estrogen◯ Yoshinori Okamoto, Akira Aoki, Hideto Jinno(Faculty of Pharmacy, Meijo University)

S-2

Supersulfide for Stress Regulation◯ Masahiro Akiyama(Department of Clinical Immuno Oncology, Clinical Research Institute for ClinicalPharmacology and Therapeutics, Showa University)

S-3

An alternative animal testing model utilizing the air-liquid interface method forinhalation toxicity risk assessment◯ Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)

S-4

Multiple mechanisms of alcohol-associated liver injury and a novel therapeutic
approach to treat liver fibrosis◯ Wonhyo Seo(College of Pharmacy, Ewha Womans University, Seoul, Korea)−56−2024 Japan/Korea Joint Symposium on Pharmaceutical Health
Science and Environmental Toxicology: Poster Session
September 4 (Wed) 14:10-14:50 Room C (1F)
PS-01

Elucidation of defense response mechanism in green microalgae Chlamydomonas
reinhardtii under copper ion exposure◯ Ryotaro Tsutsumi1, Risa Yoshimoto2, Jiro Miura3, Takuya Yamashita1,
Kazumasa Hirata1,2, Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Medical Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Grad. Sch. Dent. Sci., Osaka Univ.)

PS-02

Perfluorooctane sulfonate (PFOS)-induced functional changes on humanerythrocyte and its increased susceptibility of prothrombotic activity by a diabetic
metabolite◯ Hanjin Park, OK-Nam Bae(Department of Pharmacy, Hanyang University, Republic of Korea)

PS-03

Molecular and structural change of macrophages in mammary papilla of lactating
female mice
◯ Yukiko Marunaka, Kei Nakayama, Hiroshi Hasegawa(Lab. Hygienic. Sci., Kobe Pharm. Univ.)

PS-04

Autophagy dysregulation and ferroptosis mediates BBB dysfunction after ZnOnanoparticle exposure◯ Seung Mi Baek, Eun-Hye Kim, Ok-Nam Bae(Department of Pharmacy, Hanyang University, Republic of Korea)

PS-05

Ambivalent role of prostacyclin synthase in inflammatory reactions◯ Toshiya Honsawa, Tsubasa Ochiai, Hiroshi Kuwata, Shuntaro Hara
(Sch. of Pharm., Showa Univ.)

PS-06

Neuroprotective effects of 5-hydroxyindole, a gut microbial metabolite, against
glutamate-induced toxicity in mouse hippocampal cells◯ Jun Ho Cho, OK-Nam Bae(Department of Pharmacy, Hanyang University, Republic of Korea)

PS-07

Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces the growth
retardation in postnatal offspring: transgenerational toxicity and the restorationby aripiprazole intervention◯ Xing Zou1, Ming Yuan1, Tomoki Takeda1,2, Yoshitaka Tanaka1, Yuji Ishii1(1Grad Sch Pharmaceuti Sci., Kyushu Univ., 2F-SEEDS)−57−

PS-08

Effects of selected pyrethroid compounds on steroidogenesis in H295R cultured
cells◯ Darlene Mae Ortiz, Handule Lee, Juyoung Park, Ngoc Minh-Hong Hoang,
Kwangsik Park
(Dongduk Womenʼs University, Seoul, Republic of Korea)

PS-09

Dihydropyrazine application to prevent and treat sepsis: therapeutic effect inmultiple organs◯ Madoka Sawai1, Yutaka Tatano1, Katsuya Miyake3, Jian-Rong Zhou2,
Taku Kaitsuka1, Hisao Kansui2, Yuu Miyauchi2, Shinji Takechi2(1Sch. Pharm., at Fukuoka. Int. Univ. Health & Welfare.,2
Fac. Pharmaceut. Sci., Sojo Univ., 3Cbmr., at Narita. Int. Univ. Health & Welfare.)

PS-10

Estrogen Receptor/Androgen Receptor Transcriptional Activation Assay for the
Pyrethroid compounds◯ Handule Lee, Juyoung Park, Darlene Mae Ortiz, Ngoc Minh-Hong Hoang,
Kwangsik Park
(College of Pharmacy, Dongduk Womenʼs University, South Korea.)

PS-11

Elucidation of the mechanism by which the cystine transporter SLC7A11 promotes
oxidative stress-induced parthanatos◯ Ryo Ito, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

PS-12

Effects of lysine acetylation on high-fat diet fed mouse model◯ Hyunchae Sim1, Yan Gao2, Ji Hyun Lee3, Ann-Yae Na4, Sunghwan Ki3,
Sangkyu Lee1
(1School of Pharmacy, Sungkyunkwan Univ.,
2
College of Pharmacy, Kyungpook Natʼl Univ., 3College of Pharmacy, Chosun Univ.,
4
KNU LAMP Research Center, Kyungpook Natʼl Univ., Republic of Korea)

PS-13

Novel induction mechanisms of Smac-independent apoptosis induced by the antitumor kinase LKB1
◯ Maki Mitsuya, Yutaro Yamada, Yusuke Hirata, Takuya Noguchi,
Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

PS-14

Role of PCBs in respiratory diseases: Analysis of their association with asthma◯ Ah-Yoon Song, Hye-Jin Jeong, Yeon-Ho Kang, Hye-In Park, YooJin Lee,
Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)−58−PS-15A sub-lethal dose of methylglyoxal treatment confers cellular resistance toferroptosis◯ Takuya Niijima1, Yusuke Hirata1, Takuya Noguchi1, Motoharu Hamada2,
Atsushi Matsuzawa1(1 Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.,
2
Dept. of Virol., Grad. Sch. of Med. Sci., Nagoya City Univ.)

PS-16

Toxicity of Pyrethroid Insecticides on Human Bronchial Epithelial Cells◯ Hye-In Park, Hye-Jin Jeong, Yeon-Ho Kang, Ah-Yoon Song, YooJin Lee,
Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)

PS-17

Elucidation of the anti-inflammatory mechanisms of new quinolone antibiotics◯ Kohei Otani, Tomohiro Kagi, Yusuke Hirata, Takuya Noguchi,
Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

PS-18

Assessing the mixture toxicity of S-421 with pyrethroid insecticides
Hye-Jin Jeong, Yeon-Ho Kang, Ah-Yoon Song, Hye-In Park, ◯ YooJin Lee,
Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)

PS-19

A comprehensive toxicological analysis of trans -fatty acids (TFAs) based on a novel
toxicity mechanism◯ Shinnosuke Kimura, Yusuke Hirata, Ryota Kojima, Naoki Kashiwabara,
Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

PS-20

PHMG-induced modulation of neutrophil and macrophage activation and its
implications for cancer development◯ Hye-Jin Jeong, Ah-Yoon Song, Yeon-Ho Kang, Hye-In Park, YooJin Lee,
Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)

PS-21

Chemical knockdown of selenoprotein P by curcuminoids◯ Wang Yinuo1,2, Takashi Toyama1, Hiroyuki Yamakoshi3, Yoshiharu Iwabuchi3,
Yoshiro Saito1(1 Laboratory of Molecular Biology and Metabolism. Grad. Sch. Pharm. Sci., Tohoku
Univ.,
2
Medicine in Traditional Chinese Medicine, Xiamen University, Malaysia,
3
Laboratory of Synthetic Chemistry. Grad. Sch. Pharm. Sci., Tohoku Univ.)−59−

PS-22

Toxicity of household chemicals in human bronchial epithelial cell associated with
autophagy and apoptosis◯ Yeon-Ho Kang, Hye-Jin Jeong, Ah-Yoon Song, Hye-In Park, YooJin Lee,
Yong Joo Park
(College of Pharmacy, Kyungsung University, Busan 48334, Republic of Korea)

PS-23

Search for genes affecting the toxicity of the dopaminergic neurotoxin MPP+
◯ Futa Suzuki, Masatsugu Miyara, Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)

PS-24

Endoplasmic reticulum stress as a key factor in bisphenol A-induced cytotoxicity
in keratinocyte HaCaT cells◯ Sou Hyun Kim1,2, Young-Suk Jung1,2(1College of Pharmacy, Pusan Natʼl Univ.,
2
Research Institute for Drug Development, Pusan Natʼl Univ. Republic of Korea)

PS-25

Evaluation of the activity of selenosugar synthase SenB by speciation and its
docking simulation◯ Karin Takahashi1, Yasunori Fukumoto2 , Noriyuki Suzuki3, Yu-ki Tanaka2,
Yasumitsu Ogra2(1Graduate School of Medical and Pharmaceutical Sciences,2
Graduate School of Pharmaceutical Sciences, Chiba University,
3
Faculty of Pharmaceutical Sciences, Toho University)

PS-26

Isoquercitrin alleviates NAFLD by modulating lipid metabolism in HepG2 cells via
AMPK activation◯ Seung Jun Noh1,2, Chawon Yun1,2, Myeong Su Choi1,2, Jae Min Jung1,2,
Young-Suk Jung1,2(1College of Pharmacy, Pusan Natʼl Univ.,
2
Research Institute for Drug Development, Pusan Natʼl Univ. Republic of Korea)

PS-27

Regulation of ferroptosis via increased expression of the selenoprotein P receptor
ApoER2 by Nrf2 in glioblastoma◯ Stephanie Siu, Xi Zheng, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

PS-28

Autophagy is crucial for the hepatoprotective effects of betaine in non-alcoholic
fatty liver disease in Mice
◯ RanJu Woo1,2, Ji Yeon Song1,2, Maziyar Veisi1,2, Young-Suk Jung1,2(1College of Pharmacy, Pusan Natʼl Univ.,
2
Research Institute for Drug Development, Pusan Natʼl Univ. Republic of Korea)−60−

PS-29Involvement of long-chain acyl CoA synthetase 4 in idiopathic pulmonary fibrosis◯ Yuki Tomitsuka, Hiroshi Kuwata, Shuntaro Hara
(Graduate Sch. of Pharmacy, Showa Univ.)

PS-30

Effects of deep ocean-derived magnesium-enhanced Water on Cardiovascular
Diseases with Microbiome Changes◯ Mihi Yang1,2(1College of Pharm. Sookmyung Womenʼs Univ.,
2
Goodbeing Center C. Ltd., Republic of Korea)

PS-31

Molecular mechanisms of cellular dysfunction caused by antibacterial
cephalosporins◯ Christian Spadini1, Tomohiro Kagi2, Wakana Suzuki2, Yusuke Hirata2,
Takuya Noguchi2, Atsushi Matsuzawa2(1Dep. Biochem., Univ. Lausanne,
2Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)−61−

Award Candidates Presentation Candidates for Rookie of the Year Award
September 4 (Wed) 9:00-10:10 Room B (Lecture Room 1)
Chair: Hitomi Fujishiro (Fac. Pharm. Sci., Tokushima Bunri Univ.)
Inhibition of ferroptosis by environmental pollutants 1,2-naphthoquinoen and
A-1(P-067) 1,4-naphthoquinoen through FSP1
◯ Kei Ishida1, Takashi Toyama1, Eikan Mishima2, Marcus Conrad2, Yoshiro Saito1(1 Fac. Pharm. Sci., Tohoku Univ. 2 Helmholtz Zentrum München)
Kinetic study of the methylation of glutathione persulfide by thiopurine
A-2(P-094) S-methyltransferase◯ Momoka Uchida1, Yasunori Fukumoto2, Yoshikazu Yamagishi3 ,Yu-ki Tanaka2,
Noriyuki Suzuki4, Yasumitsu Ogra2(1Fac. Pharm. Sci., 2Grad. Sch. Pharm. Sci., 3Grad. Sch. Med., Chiba Univ,
4
Fac. Pharm. Sci., Toho Univ.)
Determination of Acylcarnitines as a Biomarker of Insulin Poisoning by LCA-3(P-090) QTOF/MS◯ Manami Katayama1, Sayaka Nagasawa2, Hirotaro Iwase3, Yasumitsu Ogra2(1Faculty of Pharmaceutical Sciences, 2Graduate School of Pharmaceutical Sciences,3
Graduate School of Medicine, Chiba University)
Research on the search for new therapeutic agents by suppressing glioblastoma
A-4(P-064) malignant factor selenoprotein P◯ Kenya Takahashi1, Xi Zheng2, Takashi Toyama1,2, Yoshiro Saito1,2(1 Fac. Sch. Pharm. Sci., 2 Grad. Sch. Pharm. Sci., Tohoku Univ.)
Involvement of mitochondrial dysfunction in cadmium-induced impairment of
A-5(P-016) proximal tubular reabsorption◯ Miku Takahashi1, Hitomi Fujishiro1, Kanako Matsumoto1, Seiichiro Himeno2,
Daigo Sumi1(1Fac. Pharm. Sci., Tokushima Bunri Univ, 2 Fac. Pharm., Showa Univ.)
Role of ACSL4-dependent ferroptosis in inflammation-related colorectal cancer
A-6(P-080) ◯ Moe Tanaka, Tsubasa Ochiai, Toshiya Honsawa, Hiroshi Kuwata, Shuntaro Hara
(Sch. Pharm., Showa Univ.)
In situ label-free Raman imaging analyses of the intracellular environment during
A-7(P-055) ferroptosis◯ Ryota Dobashi1, Masato Machida2, Shinji Kajimoto1,2, Takakazu Nakabayashi1,2(1Fac. Pharm. Sci., Tohoku Univ.,2Grad. Sch. Pharm. Sci., Tohoku Univ.)−62−Selenoprotein P Transcriptional Regulation in the Liver
A-8(P-059) ◯ Mei Hanaki1, Mayu Yamashita2, Takayuki Kaneko2, Takashi Toyama2, Yoshiro Saito2(1Fac. Pharm. Sci., Tohoku Univ., 2Grad. Sch. Pharm. Sci., Tohoku Univ.)
Decrease in blood flow to fetus disturbs GABAergic neural subtype composition in
A-9(P-031) the prefrontal cortex◯ Saki Fujimura, Ken Takeda, Ken Tachibana, Atsuto Onoda(Fac. Pharm. Sanyo-Onoda City Univ.)
Development of inverse-BPML, a high sensitive detection method for reversible
A-10(P-063) modification of cysteine residues◯ Reiko Makino, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)−63−

Award Candidates Presentation Candidates for Young Investigator Award
September 4 (Wed) 10:10-11:30 Room B (Lecture Room 1)
Chair: Hideto jinno (Fac. Pharm., Meijo Univ.)
HIV incorporated triosephosphate isomerase suppresses the early stage of reverse
B-1(P-041) transcription◯ Towa Abe1, Naoki Kishimoto1, Satoshi Miura1, Tae Yasutake1, Nobutoki Takamune2,
Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ. 2KIDO, Kumamoto Univ.)
Elucidation of the mechanism by which cystine transporter SLC7A11 promotes
B-2(P-052) oxidative stress-induced parthanatos◯ Ryo Ito, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)
Elucidation of the regulatory mechanism of extraembryonic endoderm
B-3(P-085) differentiation by arachidonic acid
◯ Taiga Iwama, Kuniyuki Kano, Nozomu Kono, Junken Aoki
(Grad. Sch. Pharm. Sci., Univ. Tokyo)
A novel selenium acceptor molecule for selenium metabolism;inhibition of
B-4(P-066) selenium metabolism by electrophilic modification of peroxiredoxin 6◯ Hayato Takashima1, Takashi Toyama1, Junya Ito2, Eikan Mishima2, Marcus Conrad2,
Yoshiro Saito1(1Grad. Sch. Pharm. Sci., Tohoku Univ. 2 Helmholtz Munich)
Elucidating the role of polysulfidation in the iron transport protein transferrin
B-5(P-050) ◯ Miyuki Nara, Takashi Toyama, Reona Tobita, Takakazu Nakabayashi, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)
The role of Lysophosphatidylserine in the tumor microenvironment
B-6(P-084) ◯ Shun Nishikado1, Junpei Omi1, Akiharu Uwamizu1, Tomohiko Ohwada2,
Junken Aoki1(1Department of Health Chemistry, Grad. Sch. Pharm. Sci., The Univ. of Tokyo,
2
Laboratory of Organic and Medical Chemistry, Grad. Sch. Pharm. Sci., The Univ. ofTokyo)
Exhalation omics based on sulfur metabolites in chronic kidney disease
B-7(P-054) ◯ Yoshinobu Henmi1, Seiryo Ogata2, Tsuyoshi Takata2, Daisuke Saigusa3,
Eikan Mishima4, Wei Fanyan5, Takaaki Akaike2, Nobuyuki Takahashi1, Emiko Sato1(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2 Grad. Sch. Med., Tohoku Univ.,
3Fac. Pharm. Sci., Teikyo Univ., 4Tohoku Univ. Hospital.
5
Ins. Dev. Aging and Cancer., Tohoku Univ.)−64−Anti-inflammatory role of prostacyclin synthase in lipopolysaccharide-induced
B-8(P-078) inflammation◯ Toshiya Honsawa, Tsubasa Ochiai, Hiroshi Kuwata , Shuntaro Hara
(Sch. of Pharm., Showa Univ.)
PS-PLA1-LysoPS AXIS IN INFECTIOUS IMMUNITY
B-9(P-077) ◯ Shun Yaginuma, Jumpei Omi, Kuniyuki Kano, Junken Aoki
(Grad. Sch. Pharm. Sci., Tokyo Univ.)−65−Oral Session 1
September 4 (Wed) 16:00-17:00 Room B (Lecture Room 1)
Chairs: Shusuke Kuge (Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)
Masaki Matsuoka (Sch. of pharm., Kitasato Univ.)
O1-1

Transcription factor SOX10 regulates melanoma growth through RXR gamma
expression◯ Hana Ishizuka, Yue Zhou, Hiroaki Sakurai, Satoru Yokoyama(Grad. Sch. Pharm. Sci., Toyama Univ.)

O1-2

Effect of extracellular vesicles derived from the serum of fish on human umbilicalvein endothelial cells◯ Akiha Onuma, Takuya Yamashita, Ryotaro Tsutsumi, Kazuya Nagano(Sch. Pharm. Sci., Wakayama Med. Univ.)

O1-3

Effect of nursing burden on the thymic recovery in lactating female mice
◯ Kei Nakayama, Hiroshi Hasegawa(Lab. Hygienic Sci., Kobe Pharm. Univ.)

O1-4

Acidic sophorose lipid exhibits the lower cell toxicity and wider safety range incomparison to other biosurfactants such as surfactin and rhamnose lipid◯ Yuki Miyazaki1, Ryotaro Tsutsumi1, Erika Kunimi2, Michiaki Araki3,
Yoshihiko Hirata3, Misa Muraoka2, Hirofumi Tsujino2, Masayoshi Arai2,
Kazumasa Hirata1,2, Takuya Yamashita1, Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Medical Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Saraya Co., Ltd)

O1-5

Elucidation of the mechanism of lysosomal hydrolase insolubilization duringlysosomal membrane damage◯ Futa Suzuki1, Natsumi Fujiwara1, Kanae Miyara1, 2, Ayaka Yabuki1, Shuhei Hamano3,4,
Takuya Noguchi3, Atsushi Matsuzawa3, Masatsugu Miyara1, Yaichiro Kotake1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2JSPS Research Fellow RPD.,
3
Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 4JSPS Research Fellow DC.)

−66−

Oral Session 2
September 4 (Wed) 17:00-18:00 Room B (Lecture Room 1)
Chairs: Kuniyuki Kano (Grad. Sch. Pharm. Sci., Univ. Tokyo)
Ryota Shizu (Sch. Pharm. Sci., Univ. of Shizuoka)
O2-1

Time-resolved transcriptomic profiling of senescence-associated secretory
phenotype (SASP) in multiple senescent cell subtypes◯ Nurhanani Razali1,2, Yohsuke Moriyama1, Yatzu Chiu1, Kojiro Suda1,
Mari Kondo2, Hiroshi Hasegawa2, Keiko Kono1（1Membranoloy Unit, Okinawa Ins. of Sci. and Tech. Graduate Univ.,
2Lab. of Hygienic Sci., Kobe Pharm. Univ.）

O2-2

Phenotypic analysis of cartilage-specific vitamin K converting enzyme UBIAD1
knockout mice
◯ Shunsuke Hirashima, Anna Koiso, Takuzi Takayama, Eri Kuboki, Karin Okumura,
Takashi Kimoto, Kimie Nakagawa(Fac. Pharm. Sci., Kobegakuin Univ.)

O2-3

The Importance of the Methyl Group at the 2-Position of the Naphthoquinone
Ring in Vitamin K Conversion Reactions◯ Kurumi Nakagawa1, Kohei Murata1, Syunta Sudo2, Yoshitomo Suhara1,2,
Yoshihisa Hirota1,2(1Grad. Sch. Pharm. Sci., Shibaura Inst. of Tech., 2Dep. Life. Sci., Shibaura Inst. of Tech.)O2-4

Establishment of Menadione and its conjugates assay for application as a urinary
biomarker for vitamin K-related diseases◯ Shintaro Tagami1, Satoshi Asano1, Maya Kamao2, Yoshitomo Suhara1,
Miyuu Nishikawa3, Shinichi Ikushiro3, Yoshihisa Hirota1(1Grad. Sch. Pharm. Sci., Shibaura Inst. of Tech., 2Ex. Center, Kobe Pharmaceutical Univ.,
3
Faculty of Engineering, Toyama Prefectural Univ.)

O2-5

Pharmacokinetics of Hybrid Vitamin K Derivatives Incorporating Retinoic Acid
Structure Oriented for the Treatment of Neurodegenerative Diseases◯ Yoshihisa Hirota1, Rina Watanabe1, Kazuki Takeda2, Yoshitomo Suhara1(1 Grad. Sch. Pharm. Sci., Shibaura Inst. Tec., 2 Sch. Vet. Med., Kitasato Univ.)−67−

Oral Session 3
September 5 (Thu) 9:00-10:00 Room B (Lecture Room 1)
Chairs: Takamitsu Unoki (Dept. Basic Med. Sci., Nat. Inst. Minamata Dis.)
Maki Tokumoto (Sch. Pharm., Aichi Gakuin Univ.)
O3-1

Overlap of Genetic Predisposition and Maternal Exposure to Nanoparticles
Synergistically Increases Risk of Autism spectrum disorder-like behavior◯ Atsuto Onoda, Risa Fuku, Tadashi Nakagawa, Ken Tachibana, Ken Takeda(Fac. Pharm. Sanyo-Onoda city Univ.)

O3-2

Mechanistic analysis of tolerance/recovery response in green microalgae
Chlamydomonas reinhardtii under copper ion exposure◯ Shunsuke Hatano1, Ryotaro Tsutsumi1, Risa Yoshimoto2, Jiro Miura3,
Takuya Yamashita1, Kazumasa Hirata1, 2, Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Medical Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Grad. Sch. Dent. Sci., Osaka Univ.)

O3-3

Effect of multiple concomitant drugs for hyperphosphatemia on phosphorus
adsorption capacity◯ Kaito Yamashiro1,2, Kazuma Kimata2, Fumihiko Ogata2, Yasuyuki Fujiwara1,
Naohito Kawasaki2,3(1 School of Pharmacy, Tokyo University of Pharmacy and Life Sciences,
2
Faculty of Pharmacy, Kindai University, 3Anti-aging Center, Kindai University)

O3-4

Analysis of mole removal creams with reported health hazards◯ Tsuyoshi Kawakami, Maiko Tahara, Sachie Kawano, Nahoko Uchiyama(NIHS)

O3-5

Repeated exposure to MBP, a metabolite of bisphenol A, stimulates ligandindependent estrogen receptors-mediated transcription in long-term estrogendeprived breast cancer cells◯ Masayo Hirao-Suzuki1, Masufumi Takiguchi1, Shuso Takeda2(1Fac. Pharm. Sci., Hiroshima Intl. Univ., 2Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ.)−68−Oral Session 4
September 5 (Thu) 10:00-11:00 Room B (Lecture Room 1)
Chairs: Kotoko Arisawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
Naoki Kishimoto (Grad. Sch. Pharm. Sci., Kumamoto Univ.)
O4-1

Functional analysis of long-chain acyl CoA synthetase 4 in idiopathic pulmonary
fibrosis◯ Yuki Tomitsuka, Hiroshi Kuwata, Shuntaro Hara
(Graduate Sch. of Pharmacy, Showa Univ.)

O4-2

Effect of supersulfides in lipid oxidation dependent cell death by lipoxytosis
inducers◯ Shu Yasuda1, Ayaka Enomoto1, Takara Hashimoto1, Maho Morita1, Tomohiro Sawa2,
Tomoko Koumura1, Masaki Matsuoka1, Hirotaka Imai1(1Grad. Sch. Pharm. Sci., Kitasato Univ, 2Grad. Sch. Med. Sci., Kumamoto Univ.)

O4-3

Mechanism of 1,2-dichloropropane for induction of DNA damage in humancholangiocytes co-cultured with macrophages◯ Mst. Mahfuza Rahman1, Cai Zong1, Kyoshiro Kusagaya1, Yusuke Kimura2,
Abigail Ekuban1, Ryouya Takizawa2, Sahoko Ichihara2, Gaku Ichihara1（1Department of Occupational and Environmental Health, Faculty of Pharmaceutical
Sciences, Tokyo University of Science, Noda, Japan,
2
Department of Environmental and Preventive Medicine, Jichi Medical University
School of Medicine, Shimotsuke 329-0498, Japan）

O4-4

Functional analysis of Lipo-2 gene in Lipoxytosis pathway◯ Masaki Matsuoka, Ryuya Kobayashi, Hirotaka Imai
(Kitasato univ. Sch. of pharm.)

O4-5

Development of broad-spectrum antiviral drugs effective against humancoronaviruses and influenza A virus◯ Shusuke Kuge1, Ryoya Sekine1, Tsukasa Suenaga1, Maki Kiso2, Seiya Yamayoshi2,
Yoshihiro Kawaoka2, Hidekazu Nishimura3, Kouki Takeda1(1 Fac. Pharm. Sci, Tohoku Med. Pharm. Univ., 2Inst. Med. Sci., Univ. Tokyo,
3
Sendai Med. Center)−69−

Oral Session 5
September 5 (Thu) 14:20-15:20 Room B (Lecture Room 1)
Chairs: Hayato Irokawa (Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)
Tsutomu Takahashi (Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)
O5-1

Mitochondrial H2O2-Zn2+ signaling induces nigral dopaminergic degeneration◯ Atsushi Takeda1, Takato Chinen1, Miki Sasaki1, Haruna Tamura1, Ryusuke Nishio1,
Haruna Tamano1,2(1 Sch. Pharm. Sci., Univ. Shizuoka,2 Shizuoka Tohto Med. Col.)

O5-2

Neuroprotective effects of sulforaphane on benzo[a]pyrene-induced neurotoxicity
in mice◯ Yousra Reda1,2, Cai Zong1, Ikoma Akane 1, Saleh Ahmed1, Alzahraa Fergany1,
Sahoko Ichihara3, Gaku Ichihara1（1 Department of Occupational and Environmental Health, Faculty of Pharmaceutical
Sciences, Tokyo University of Science, Noda 278-8510, Japan,
2
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine,
Suez Canal University, Ismailia, Egypt,3
Department of Environmental and Preventive Medicine, Jichi Medical University
School of Medicine, Shimotsuke, Japan.）O5-3

Impact of Benzo[a]pyrene Exposure on Central Nervous System of Mice
Walaa Slouma Hamouda Abd El Naby1,2, Cai Zong1, Yousra Reda1,3, Sahoko Ichihara4,
Natsuko Kubota5, Shinya Yanagita5 , ○ Gaku Ichihara1（1Department of Occupational and Environmental Health, Faculty of Pharmaceutical
Sciences, Tokyo University of Science, Noda 278-8510, Japan,
2
Genetics and Genetic Engineering in Department of Animal Husbandry and Animal
Wealth Development, Faculty of Veterinary Medicine, Alexandria University,
Alexandria 21500, Egypt,3
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine,
Suez Canal University, Ismailia, Egypt.,4Department of Environmental and Preventive Medicine, Jichi Medical University
School of Medicine, Shimotsuke, Japan,
5
Faculty of Science and Technology, Tokyo University of Science, Noda 278-8510,
Japan.）O5-4

The ATX-LPA-LPA2 Axis Suppresses Apoptosis of Spermatogenic Cells andDetermines Sperm Count◯ Kuniyuki Kano1, Takumi Sugawara2, Nozomu Kono1, Junken Aoki1(1Grad. Sch. Pharm. Sci., The Univ of Tokyo., 2Grad. Sch. Pharm. Sci., Tohoku Univ)

−70−

O5-5

Involvement of N-nitroso bile acid conjugates in the occupational
cholangiocarcinoma of 1,2-dichloropropane◯ Shinya Hasegawa1, Asmaa Elzawahry2, Momoko Nagai2, Mamoru Kato2,
Tomonari Matsuda3, Yukari Totsuka1(1 Hoshi Univ., 2 Natl. Cancer Ctr. Res. Inst., 3Kyoto Univ.)

Oral Session 6
September 5 (Thu) 15:20-16:20 Room B (Lecture Room 1)
Chairs: Akinori Sugiyama (Sch. Pharm., Iwate Medical Univ.)
Yasukazu Takanezawa (Sch. of pharm., Kitasato Univ.)
O6-1

Efficient evaluation of male reproductive toxicity focused on seminiferous
epithelium cycle◯ Satoshi Yokota1,2, Tomohiko Wakayama2, Hirokatsu Saito1, Satoshi Kitajima1(1 NIHS, 2 Grad. Sch. Med. Sci., Kumamoto Univ.)

O6-2

Effect of co-intake with indigestible dextrin and the other food ingredients on thetriglyceride-lowering function by indigestible dextrin◯ Ayumi Kano1, Miki Harada2, Tomohiro Nakao3, Makoto Sakata3, Masayuki Nishino3,
Kazumasa Hirata1,2, Ryotaro Tsutsumi1, Takuya Yamashita1, Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Med. Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
San-Ei Gen F. F. I)

O6-3

A comprehensive toxicological assessment of trans -fatty acids based on a novel
mechanism of their toxic actions◯ Naoki Kashiwabara, Yusuke Hirata, Ryota Kozhima, Shinnosuke Kimura,
Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

O6-4

Mechanistic analysis of brest cancer metastasis using our quantification method
for urinary prostanoid metabolites◯ Yuma Kawamura1, Takuya Yamashita1, Tian-Qi Zhang2, Yasuo Tsutsumi2,
Soshi Terada2, Kazumasa Hirata1,2, Ryotaro Tsutsumi1, Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Med. Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.)

O6-5

The activity of curcumin, a poorly water-soluble bioactive substance, depends on
initial dispwersion solvent◯ Kodai Hattori1, Hikaru Maekita2, Tomohiro Nakao3, Makoto Sakata3,
Masayuki Nishino3, Yasuo Tsutsumi2 Ryotaro Tsutsumi1, Takuya Yamashita1,
Kazuya Nagano1(1Sch. Pharm. Sci., Wakayama Med. Univ., 2 Grad. Sch. Pharm. Sci., Osaka Univ.,
3
San-Ei Gen F. F. I.)−71−

Poster Session
September 4 (Wed) 14:10-14:50 Room C (1F)
P-001

Metabolism of volatile aromatic compounds by CYP and UGT expressed in themouse olfactory epithelium and their inhibition by drugs○ Naoki Takaoka, Ayana Nishide, Seigo Sanoh, Shigeru Ohta
(Sch. Pharm. Sci., Wakayama Med. Univ.)

P-002

Silver nanoparticles change their form during the process of oral absorption◯ Takuya Yamashita1, Ikkei Tasaki1, Yasuo Tsutsumi2, Kazuya Nagano1(1School of Pharmaceutical Sciences, Wakayama Medical University,
2
Graduate School of Pharmaceutical Sciences, Osaka University)

P-003

Analysis of the Effect of Statins on MK-4 Synthesis by Vitamin K Converting
Enzyme UBIAD1◯ Takashi Kimoto, Shunsuke Hirashima, Yuina Nakagami, Yoshiaki Nishino,Ami Hamade, Kimie Nakagawa(Fac. Pharm., Kobe Gakuin Univ.)

P-004

Inhibitory effect of phthalate esters on the migration of human trophoblastderived HTR-8/SVneo cells◯ Shoko Ogushi1, Seira Mori1, Takehiro Nakamura1, Tsuyoshi Nakanishi2,
Tomoki Kimura1(1Fac. Farm. Sci., Setsunan Univ., 2Gifu Pharm. Univ.)

P-005

Inhibitory effect of an extract from the peel of Akebia quinata (Lardizabalaceae)
on proliferation of human breast cancer MCF-7 cells◯ Sakura Masaka1, Aoi Aisaka1, Makoto Ohira1, Tsukasa Matsumoto1,2,
Keiichi Matsuzaki3, Yasushi Kawasaki1, Akira Sato1,4(1 Fac. Pharm., Iryo Sosei Univ., 2Grad. Sch. Life Sci. Tech., Iryo Sosei Univ.,
3
Sch. Pharm., Nihon Univ., 4 Fac. Human Life Sci., Miyagi Gakuin Womenʼs Univ.)

P-006

Enrichment effect on urinary function in drug-induced menopause model miceand the relationship between brain molecules in the hippocampus◯ Fumio Soeda, Ryo Yokoo, Mayo Kubota, Tatsuya Oda, Takayuki Koga,
Yuko Kobuke(Daiichi Univ. Pharm.)

P-007

Effect of PPARA on mitochondrial DNA gene expression◯ Daisuke Aibara, Kimihiko Matsusue(Faculty of Pharmaceutical Science, Fukuoka University)−72−

P-008Regulation of hepatic Sprr1a expression by PPARγ◯ Daisuke Aibara, Ai Sakaguchi, Kohei Matsuo, Kimihiko Matsusue(Faculty of Pharmaceutical Science, Fukuoka University)

P-009

Novel inhibitory mechanisms of hepatic fat accumulation through PPARγresponsive hepatic microRNA 4◯ Kohei Matsuo, Daisuke Sakamoto, Ai Sakaguchi, Daisuke Aibara,
Nobuhiro Kashige, Kimihiko Matsusue(Fac. Pharmaceut. Sci., Fukuoka. Univ.)

P-010

Ablation of SBP1 suppresses high-fat diet-induced obesity◯ Takayuki Koga1, Makoto Hiromura1, Syota Kagawa1, Masayo Hirao-Suzuki2,
Shuso Takeda3, Yuji Ishii4, Takumi Ishida5, Fumihiro Nagashima1, Yuko Kobuke1,
Akihisa Toda6 Fumio Soeda1(1Daiichi Univ. Pharm., 2Fac. Pharm. Sci., Hiroshima Intl. Univ.,
3Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ.,
4Grad. Sch. Pharmaceut. Sci., Kyushu Univ.,
5Sch. Pharm. Fukuoka, Int. Univ. Health & Welfare, 6Kyushu Nutrition Welfare Univ.)

P-011

Interaction with phosphate ion using adsorbents derived from magnesium or
calcium◯ Yugo Uematsu, Natsuki Hiroe, Fumihiko Ogata, Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-012

Preparation of the carbonaceous material produced from waste basil seed and its
adsorption capacity of gadolinium ions from aqueous phase◯ Fumihiko Ogata, Nanami Matsumoto, Yugo Uematsu, Naohito Kawasaki(Fac. Pharm., Kindai. Univ.)

P-013

Role of SeBP1 in acetaminophen-induced liver injury◯ Shuangli Zhao1, Yingxia Song1, Renshi Li2, Takayuki Koga3, Takumi Ishida4,
Yoshitaka Tanaka1, Yuji Ishii1(1Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 2China Pharmaceut. Univ.,3
Daiichi Univ. Pharm., 4Int. Univ. Health Welfare Fukuoka)

P-014

Possible mechanism underlying disruption of the folate metabolism in the fetal
hypothalamus caused by maternal exposure to TCDD
◯ Yuki Ishiiyama1, Mana Fujimoto2, Hiroe Sano2, Takayuki Koga3, Yoshitaka Tanaka2,
Yuji Ishii2(1Fac. Pharmaceut. Sci. &, 2Grad. Sch. Pharmaceut. Sci., Kyushu Univ.,3
Daiichi Univ. Pharm.)−73−

P-015

Nobiletin ameliorates dioxin-induced male and female fetal growth hormone
suppression: possible involvement of attenuation of the CYP3A induction◯ Ryoto Hiyama1, Hongbin Chen1, Chiho Ohta2, Nobuyuki Koga2, Yoshitaka Tanaka1,
Yuji Ishii1(1Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 2Nakamura Gakuen Univ.)

P-016

Involvement of mitochondrial dysfunction in cadmium-induced impairment ofproximal tubular reabsorption◯ Miku Takahashi1, Hitomi Fujishiro1, Kanako Matsumoto1, Seiichiro Himeno2,
Daigo Sumi1(1Fac. Pharm. Sci., Tokushima Bunri Univ, 2 Fac. Pharm., Showa Univ.)

P-017

Investigation of cadmium injury models using metallothionein-knockout mice
◯ Kanako Matsumoto1, Hitomi Fujishiro1, Shota Hori1, Takashige Kawakami1,
Seiichiro Himeno2, Daigo Sumi1(1 Fac. Pharm. Sci., Tokushima Bunri Univ, 2 Sch. Pharm. Sci., Showa Univ.)

P-018

Investigation of underlying mechanisms of delayed renal injury by short-term
cisplatin exposure◯ Hiroki Taguchi1, Hitomi Fujishiro1,2, Ayumi Uemura2, Daigo Sumi1,2(1 Grad. Sch. Pharm. Sci., Tokushima Bunri Univ., 2 Fac. Pharm. Sci., Tokushima Bunri
Univ.)

P-019

Decrease of endotoxin in brown rice by polishing and cooking◯ Ruri Hamada, Yuya Deguchi, Hiroaki Nagaoka(Fac. Pharm. Sci., Nagasaki Intl. Univ.)

P-020

Kahweol inhibits renal fibroblast transdifferentiation through phosphorylation of
STAT3◯ Minatsu Iyogi1, Mana Nagasawa1, Yasushi Kawasaki2, Akinori Sugiyama1(1 Sch. Pharm., Iwate Medical Univ., 2 Fac. Pharm., Iryo Sosei Univ.)

P-021

Cafestol inhibits renal fibroblast transdifferentiation and is involved in STAT3
inactivation◯ Mana Nagasawa1, Minatsu Iyogi1, Yasushi Kawasaki2, Akinori Sugiyama1(1 Sch. Pharm., Iwate Medical Univ., 2 Fac. Pharm., Iryo Sosei Univ.)

P-022

Green tea catechin protects vascular endothelial barrier function◯ Rio Wakasugi1, Saki Ishii2, Yuri Sagara2, Kenji Suzuki1,2, Takako Kaneko-Kawano1,2(1Grad. Sch. Pharm., Ritsumeikan Univ., 2 Col. Pharm. Sci., Ritsumeikan Univ.)−74−

P-023

Advanced Quality Assessment of Sanshishi (Gardenia jasminoides Ellis) andKampo Medicines Using a Monoclonal Antibody Against Geniposide◯ Riko Nishiura1, Kanta Noguchi2, Nuntawong Poomraphie2, Daisuke Imahori1,
Hiroyuki Tanaka1, Seiichi Sakamoto2(1Fac. Pharm. Sci., Sanyo-Onoda City Univ., 2Grad. Sch. Pharm. Sci., Kyushu Univ.)

P-024

Brain dynamics of abnormally structured proteins induced by nanoparticles◯ Yutaro Yagi1, Naoya Sakaguchi2, Masakazu Umezawa2, Ken Tachibana1,
Ken Takeda1, Atsuto Onoda1(1Dep. Pharm., Sanyo-Onoda City Univ, 2Dep. Materials and Technology, Tokyo Univof Science)

P-025

Simultaneous high-performance liquid chromatography analysis ofanthraquinones in sicklepod sprouts with α-glucosidase inhibitory activity◯ Sachiko Katayama, Takuya Muraoka, Daisuke Imahori, Hiroyuki Tanaka(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-026

Chemical structure of constituents obtained from the seeds of Citrus junos◯ Daisuke Imahori, Miharu Kubota, Takuya Muraoka, Hiroyuki Tanaka(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-027

Effects of acrylamide exposure on mouse neural stem cells◯ Ayano Kaida, Atsuto Onoda, Ken Takeda, Ken Tachibana(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-028

Effects of exposure to paroxetine on mouse neural stem cells◯ Yuki Yoshimoto, Atsuto Onoda, Ken Takeda, Ken Tachibana(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-029

Effects of acetaminophen and its metabolites on mouse neural stem cells◯ Sachi Horike, Atsuto Onoda, Ken Takeda, Ken Tachibana(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-030

Effect of Fetal Growth Restriction on the Cerebellar Development: Localizationand Morphology of Purkinje Cells during Developmental Period◯ Wakana Yamada, Ken Tachibana, Ken Takeda, Atsuto Onoda(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-031

Decrease in blood flow to fetus disturbs GABAergic neural subtype composition in
the prefrontal cortex◯ Saki Fujimura, Ken Takeda, Ken Tachibana, Atsuto Onoda(Fac. Pharm. Sanyo-Onoda City Univ.)−75−

P-032Analysis of the transcriptional regulatory region of the mouse aldehyde oxidase 3
gene◯ Hiroya Mitsuduka1, Yoshitaka Tayama2, Kazumi Sugihara2, Seigo Sanoh3,
Atsuto Onoda1, Ken Takeda1, Ken Tachibana1(1Fac. Pharm. Sanyo-Onoda city Univ., 2Fac. Pharm. Sci., Hiroshima Intl. Univ.,
3
Sch.Pharm.Sci., Wakayama Med.Univ.)

P-033

Study on the cardiac extrasystoles induced by heated tobacco aerosol exposure inmice◯ Akira Ushiyama1, Yohei Inaba1, Sawako Shindo2, Kenji Hattori2(1 Dep. Env. Health, National Institute of Public Health.,
2Fac. Pharm. Sci., Meiji Pharm. Univ.)

P-034

Elucidation of the direct effects of fragrance substances on the brain◯ Ami Oguro, Hideaki Sato, Taichi Fujiyama, Saki Nagai, Nozomi Mizutani,
Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci, Hiroshima Univ.)

P-035

Transcriptome analysis in the substantia nigra of a chronic MPTP mouse model ofParkinson’s disease◯ Masatsugu Miyara, Monami Yada, Natsumi Okada, Futa Suzuki, Natsumi Fujiwara,
Honoka Hashimoto, Kanae Miyara, Shunichi Hatamiya, Saya Takao, Yusuke Kojima,
Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)

P-036

Detection of phytohormone disrupting effects of PPCPs using Arabidopsis thaliana
T87 cells
Taro Imura, Keisei Ohnishi, Reiji Sadamatsu, Ryo Ujihara, Ryo Shimizu,○ Kazumi Sugihara(Faculty of Pharmaceutical Sciences, Hiroshima International University)

P-037

Effects of bisphenol A metabolite on progesterone receptor (PR) expression ofbreast cancer cells: A comparative study between single and repeated exposuresystem◯ Michitaka Tanaka1, Masayo Hirao-Suzuki1, Sawa Kawanami1, Shuso Takeda2,
Masufumi Takiguchi1(1Fac. Pharm. Sci., Hiroshima Intl. Univ.,
2Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ.)−76−P-038Changes in general symptoms and increased mortality after cerebral ischemic
stroke due to long-term exposure to fine particulate matter (PM2.5)◯ Nami Ishihara, Naoyuki Nezu, Kaede Namba, Shinji Kawano, Miki Tanaka,
Yasuhiro Ishihara(Grad. Sch. Integr. Sci. Life, Hiroshima Univ.)

P-039

Influence of Neopyropia yezoensis on the growth of indigenous bacteria related toskin condition◯ Narumi Sugihara1, Akihiro Michihara1, Yuka Nagatsuka1, Kengo Banshoya1,
Yuuki Satou1, Yukimasa Yamagishi2, Yasuhiko Miwa2, Koki Kanameda1,
Masayo Hirao-Suzuki3, Shuso Takeda1(1Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ., 2Fac. Life Sci., Fukuyama Univ.,
3Fac. Pharm. Sci., Hiroshima Intl. Univ.)

P-040

Regulation of conjugation activity of UDP-glucuronosyltransferase through the
C-terminal lysine residue(s)◯ Yuu Miyauchi1, Madoka Sawai2, Shinji Takechi1, Yuji Ishii3(1Fac. Pharmaceut. Sci., Sojo Univ.,
2Sch. Pharm. at Fukuoka, Int. Univ. Health & Welfare,3
Grad. Sch. Pharm. Sci., Kyushu Univ.)

P-041

HIV incorporated triosephosphate isomerase suppresses the early stage of reverse
transcription◯ Towa Abe1, Naoki Kishimoto1, Satoshi Miura1, Tae Yasutake1, Nobutoki Takamune2,
Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ. 2KIDO, Kumamoto Univ.)

P-042

Vaccine immunogenicity influenced by nutritional status of infected cells◯ Shunsuke Sasaki1, Naoki Kishimoto1, Nobutoki Takamune2, Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ.
2
Kumamoto innovative development organization)

P-043

Analysis of the mechanism of autophagy suppression by the glycation productdihydropyrazine◯ Yuka Orita1, Yuu Miyauchi1, Madoka Sawai2, Shinji Takechi1(1Fac. Pharmaceut. Sci., Sojo Univ.,
2Sch. Pharm., at Fukuoka. Int. Univ. Health & Welfare)P-044

Analysis of cell death by the glycation product dihydropyrazine◯ Moeka Iwayama1, Yuu Miyauchi1, Madoka Sawai2, Shinji Takechi1(1Fac. Pharmaceut. Sci., Sojo Univ.,
2Sch. Pharm., at Fukuoka. Int. Univ. Health & Welfare)−77−P-045Functional analysis of metallothionein (MT) against lung injury caused by air
pollutants and establishment of preventive methods◯ Ken-ichiro Tanaka1, Yui Uehara1, Rioko Funayama1, Mikako Shimoda1,
Akio Sugimoto2, Masaki Ichitani2, Yoshito Kadota3, Takashige Kawakami3,
Shinya Suzuki3, Masahiro Kawahara1,(1Fac. Pharm., Musashino Univ., 2Central Research Institute, ITO EN.,
3
Fac. Pharm. Sci., Tokushima Bunri Univ.)

P-046

Decreased protein supersulfides in neurons exposed to methylmercury◯ Takamitsu Unoki1, Masahiro Akiyama2, Yoshito Kumagai3, Masatake Fujimura1(1Dept. Basic Med. Sci., Nat. Inst. Minamata Dis.,
2
Clin. Res. Inst. Clin. Pharm. Ther., Showa Univ., 3Grad. Sch. Pharm. Sci., Kyushu Univ.)

September 5 (Thu) 16:30-17:10 Room C (1F)
P-047

Analysis of the Inhibitory Mechanism of Selenium Metabolism in Inflammatory
Macrophages and Its Physiological Significance◯ Mayumi Sugawara1, Kotoko Arisawa2, Hayato Takashima2, Yoshiro Saito1,2(1 Fac. Pharm. Sci., Tohoku Univ.,2 Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-048

Elucidation of the anti-inflammatory mechanisms of new quinolone antibiotics◯ Kohei Otani, Tomohiro Kagi, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-049

Development of new therapeutics for inflammation using novel seleniumcontaining compounds◯ Shunsuke Yogiashi1, Takashi Toyama1, Masana Yazaki2, Mieko Arisawa2,
Yoshiro Saito1(1 Fac. Pharm. Sci., Tohoku Univ. 2 Fac. Agri. Kyushu Univ.)

P-050

Elucidating the role of polysulfidation in the iron transport protein transferrin◯ Miyuki Nara, Takashi Toyama, Reona Tobita, Takakazu Nakabayashi, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-051

Mechanism of intracellular selenium storage by the selenium transport protein
Selenoprotein P◯ Atsuya Ichikawa, Takashi Toyama, Kotoko Arisawa, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)−78−

P-052

Elucidation of the mechanism by which cystine transporter SLC7A11 promotes
oxidative stress-induced parthanatos◯ Ryo Ito, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-053

Analysis of redox regulation of pyruvate kinase (PK) in hepatocytes◯ Hayato Irokawa, Kouki Takeda, Shusuke Kuge
(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)

P-054

Exhalation omics based on sulfur metabolites in chronic kidney disease◯ Yoshinobu Henmi1, Seiryo Ogata2, Tsuyoshi Takata2, Daisuke Saigusa3,
Eikan Mishima4, Wei Fanyan5, Takaaki Akaike2, Nobuyuki Takahashi1, Emiko Sato1(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2 Grad. Sch. Med., Tohoku Univ.,
3Fac. Pharm. Sci., Teikyo Univ., 4Tohoku Univ. Hospital.
5
Ins. Dev. Aging and Cancer., Tohoku Univ.)

P-055

In situ label-free Raman imaging analyses of the intracellular environment during
ferroptosis◯ Ryota Dobashi1, Masato Machida2, Shinji Kajimoto1,2, Takakazu Nakabayashi1,2(1Fac. Pharm. Sci., Tohoku Univ.,2Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-056

The functional role of the cleavage of the multifunctional protein p62 by caspase-8◯ Ryuto Komatsu, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-057

A unique anti-ferroptotic mechanism of a food-derived compound◯ Ryota Kojima1, Yusuke Hirata1, Takuya Noguchi1, Yoshiro Saito2, Yoichi Kurokawa3,
Atsushi Matsuzawa1(1Lab. of Health Chem.,
2
Lab. of Mol. Biol. and Metab., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.,
3
Dept. of Biosci. and Biotech., Fukui Prefect. Univ.)

P-058

Chemical knockdown of selenoprotein P by curcuminoids◯ Wang Yinuo1, Takashi Toyama1, Hiroyuki Yamakoshi2, Yoshiharu Iwabuchi2,
Yoshiro Saito1(1Laboratory of Molecular Biology and Metabolism. Grad. Sch. Pharm. Sci., Tohoku Univ.,
2
Laboratory of Synthetic Chemistry. Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-059

Selenoprotein P Transcriptional Regulation in the Liver◯ Mei Hanaki1, Mayu Yamashita2, Takayuki Kaneko2, Takashi Toyama2, Yoshiro Saito2(1Fac. Pharm. Sci., Tohoku Univ., 2Grad. Sch. Pharm. Sci., Tohoku Univ.)−79−P-060Regulation of ferroptosis via increased expression of the selenoprotein P receptor
ApoER2 by Nrf2 in glioblastoma◯ Stephanie Siu, Xi Zheng, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-061

Pb induces a novel cell death in neuronal differentiating cells via endoplasmic
reticulum stress◯ Satoru Shiina, Takayuki Kaneko, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-062

Role of TXNIP in neuronal cell death induced by methylmercury◯ Naoya Yamashita, Sojun Yadoya, Ryota Yamagata, Gi-Wook Hwang(Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.)

P-063

Development of inverse-BPML, a high sensitive detection method for reversible
modification of cysteine residues◯ Reiko Makino, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-064

Research on the search for new therapeutic agents by suppressing glioblastoma
malignant factor selenoprotein P◯ Kenya Takahashi1, Xi Zheng2, Takashi Toyama1,2, Yoshiro Saito1,2(1 Fac. Sch. Pharm. Sci., 2 Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-065

Mechanisms of correlation between selenoprotein P and iron metabolism◯ An Masuda1, Moeka Natori1, Kotoko Arisawa2, Yoshiro Saito2(1 Fac. Pharm. Sci., Tohoku Univ., 2 Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-066

A novel selenium acceptor molecule for selenium metabolism;inhibition ofselenium metabolism by electrophilic modification of peroxiredoxin 6◯ Hayato Takashima1, Takashi Toyama1, Junya Ito2, Eikan Mishima2, Marcus Conrad2,
Yoshiro Saito1(1Grad. Sch. Pharm. Sci., Tohoku Univ. 2 Helmholtz Munich)P-067

Inhibition of ferroptosis by environmental pollutants 1,2-naphthoquinoen and
1,4-naphthoquinoen through FSP1
◯ Kei Ishida1, Takashi Toyama1, Eikan Mishima2, Marcus Conrad2, Yoshiro Saito1(1 Fac. Pharm. Sci., Tohoku Univ. 2 Helmholtz Zentrum München)

P-068

Neurobehavioral changes in offspring mice exposed to methylmercury in theprenatal and postnatal stages◯ Ryota Yamagata, Natsuko Kayama, Naoya Yamashita, Gi-Wook Hwang(Fac. of Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.)−80−

P-069

Association between the use of antifungal medication during pregnancy and majorcongenital malformations in infants◯ Tadaharu Kunitoki1, Taku Obara2, Yuna Yoshida1, Haruto Watanabe3,
Seiko Yamakoshi1,3, Emiko Sato1,3, Nobuyuki Takahashi1,3(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2Grad. Sch. Med. Sci., Tohoku Univ.,
3Fac. Pharm. Sci., Tohoku Univ.)

P-070

Association between the use of SSRI during pregnancy and MCMs in infants◯ Haruto Watanabe1, Taku Obara2, Tadaharu Kunitoki3, Yuna Yoshida3,
Seiko Yamakoshi1,3, Emiko Sato1,3, Nobuyuki Takahashi1,3(1 Fac. Pharm. Sci., Tohoku Univ., 2Grad. Sch. Med. Sci., Tohoku Univ.,
3
Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-071

Evaluation of the effects of perinatal chlorpyrifos exposure on brain developmentusing neuronal differentiation reporter mice
◯ Masaki Tanaka, Keishi Ishida, Daisuke Matsumaru, Tsuyoshi Nakanishi(Gifu Pharm. Univ.)

P-072

Effects of prenatal fluorene-9-bisphenol exposure on maternal thyroid-relatedparameters and fetal development◯ Keishi Ishida, Kyoko Mekada, Daisuke Matsumaru, Tsuyoshi Nakanishi(Gifu Pharm. Univ.)

P-073

Investigation of cleft palate induced by PFAS
◯ Hiroki Yoshioka1, Yosuke Tsukiboshi1, Hanane Horita1, Aya Ogata1, Kenichi Ogata2(1 Fac. Pharm., Gifu Univ. Med. Sci., 2 Fac.Dent., Kyushu. Univ.)

P-074

Activation of the perforin-granzyme B system in cytotoxic T-lymphocytes as amechanism underlying the selective damage of granule cells in the cerebellum by
methylmercury◯ Toshiyuki Kaji1, Tsuyoshi Nakano2, Junko Kim1, Eiko Yoshida3, Ke Du4,
Tomoya Fujie1, Chika Yamamoto2, Takato Hara2, Tsutomu Takahashi5,
Yasuyuki Fujiwara5, Komyo Eto6, Yo Shinoda5(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Fac. Pharm. Sci., Toho Univ.,
3
Central Res. Inst. Elec. Power Ind., 4Sch. Pharm., China Med. Univ.,
5Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 6Jushindai)

P-075

Suppressive effects of effusol and dehydroeffusol from Juncus effusus on nigral
dopaminergic degeneration in rats induced by exposure to 6-hydroxydopamine◯ Haruna Tamano1,2, Misa Katahira2, Nana Saeki2, Atsushi Takeda2(1Shizuoka Tohto Med. Col., 2Pharm. Sci., Univ. Shizuoka)−81−P-076

Effects of Exposure to Heated Tobacco Aerosol on Hepatic Lipid Metabolism inMice Fed a High-Fat Diet
◯ Sawako Shindo1, Kodai Tsukada1, Madoka Nihei1, Yohei Inaba2, Akira Ushiyama2,
Kenji Hattori1(1Fac. Pharm. Sci., Meiji Pharm. Univ., 2Dep. Env. Health, NIPH)

P-077

PS-PLA1-LysoPS AXIS IN INFECTIOUS IMMUNITY◯ Shun Yaginuma, Jumpei Omi, Kuniyuki Kano, Junken Aoki
(Grad. Sch. Pharm. Sci., Tokyo Univ.)

P-078

Anti-inflammatory role of prostacyclin synthase in lipopolysaccharide-induced
inflammation◯ Toshiya Honsawa, Tsubasa Ochiai, Hiroshi Kuwata , Shuntaro Hara
(Sch. of Pharm., Showa Univ.)

P-079

Cell dynamics of satellite glial cells in the dorsal root ganglion of methylmercuryexposed rat◯ Misaki Ozawa1, Sawa Soneda2, Yuka Sekiguchi2, Ayaka Matsuki2, Kaito Yamashiro2,
Tsutomu Takahashi2, Yasuyuki Fujiwara2, Eiko Yoshida3, Toshiyuki Kaji4, Yo Shinoda2(1Hiroo-gakuen Senior High Sch., 2Sch. Pharm., Tokyo Univ. Pharm. Life Sci.,3CRIEPI,
4
Fac. Pharm., Tokyo Univ. Sci.)

P-080

Role of ACSL4-dependent ferroptosis in inflammation-related colorectal cancer◯ Moe Tanaka, Tsubasa Ochiai, Toshiya Honsawa, Hiroshi Kuwata, Shuntaro Hara
(Sch. Pharm., Showa Univ.)

P-081

Role of TIRAP/Mal on oxidative stress-induced NF-κB activation◯ Toshiyuki Oshima, Daisuke Watanabe, Haruka Takahashi, Keigo Tokuyama,
Yuto Wachi, Ritomu Tsuji, Mirai Toyama, Atsumi Koike, Tomofumi Fujino,
Makio Hayakawa(Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)

P-082

Analysis of a new function of EPC to prevent cell death◯ Saki Furusato1, Yukie Suto1, Masaki Matsuoka1, Asuka Shimomura2,
Toshihiro Mori2, Hirotaka Imai1(1Grad. Pharm. Sci., Kitasato Univ., 2 Mandom corp.)

P-083

Analysis of the execution pathway of cold-induced cell death (CICD)◯ Kenta Tanaka, Masaki Matsuoka, Hirotaka Imai
(Sch. Pharm. Sci. Kitasato Univ.)−82−

P-084

The role of Lysophosphatidylserine in the tumor microenvironment◯ Shun Nishikado1, Junpei Omi1, Akiharu Uwamizu1, Tomohiko Ohwada2,
Junken Aoki1(1Department of Health Chemistry, Grad. Sch. Pharm. Sci., The Univ. of Tokyo,
2
Laboratory of Organic and Medical Chemistry, Grad. Sch. Pharm. Sci., The Univ. ofTokyo)

P-085

Elucidation of the regulatory mechanism of extraembryonic endoderm
differentiation by arachidonic acid
◯ Taiga Iwama, Kuniyuki Kano, Nozomu Kono, Junken Aoki
(Grad. Sch. Pharm. Sci., Univ. Tokyo)

P-086

Role of cysteine residues in mercury transport by the mercury transporter MerC
◯ Yuka Ohshiro, Ikumi Nakayama, Shimpei Uraguchi, Ryosuke Nakamura,
Yasukazu Takanezawa, Masako Kiyono(Dept. of public Health, School of pharmacy, Kitasato Univ.)

P-087

Role of cystine transporter inhibitor in Darinaparsin-induced cytotoxicity◯ Rio Inayoshi1, Kayoko Kita1, Maki Hatakeyama1, Taro Honma1, Kozo Yao2,
Toshihide Suzuki1(1Fac. Pharm. Sci., Teikyo Univ., 2Solasia Pharma K.K.)

P-088

Therapeutic effect of onji extract on methylmercury toxicity in mice
◯ Ryosuke Nakamura, Yasukazu Takanezawa, Yuka Ohshiro, Shimpei Uraguchi,
Masako Kiyono(Sch. Pharm., kitasato Univ.)

P-089

Conversion of methylmercury into inorganic mercury via organomercurial lyase(MerB) activates autophagy and aggresome formation◯ Yasukazu Takanezawa, Kohei Ishikawa, Ryosuke Nakamura, Yuka Ohshiro,
Shimpei Uraguchi, Masako Kiyono(Dept. of Public Health, School of Pharmacy, Kitasato Univ.)

P-090

Determination of Acylcarnitines as a Biomarker of Insulin Poisoning by LCQTOF/MS◯ Manami Katayama1, Sayaka Nagasawa2, Hirotaro Iwase3, Yasumitsu Ogra2(1Faculty of Pharmaceutical Sciences, 2Graduate School of Pharmaceutical Sciences,3
Graduate School of Medicine, Chiba University)

P-091

Post-mortem degradation of flunitrazepam in blood◯ Yoshikazu Yamagishi1, Hiroyuki Inoue1, Sayaka Nagasawa1,2, Hirotaro Iwase1,
Yasumitsu Ogra1,2(1 Grad. Sch. of Med., Chiba Univ., 2 Grad. Sch. of Pharm. Sci., Chiba Univ.)−83−P-092

Effect of human serum albumin on post-mortem degradation of carbamate
pesticides◯ Momona Ikeda1, Yoshikazu Yamagishi2, Yasumitsu Ogra3(1Faculty of Pharmaceutical Sciences, Chiba University,
2
Graduate School of Medicine, Chiba University,
3
Graduate School of Pharmaceutical Sciences, Chiba University)

P-093

Evaluation of the activity of selenosugar synthase SenB by speciation and its
docking simulation◯ Karin Takahashi1, Yasunori Fukumoto2 , Noriyuki Suzuki3, Yu-ki Tanaka2,
Yasumitsu Ogra2(1Graduate School of Medical and Pharmaceutical Sciences,2
Graduate School of Pharmaceutical Sciences, Chiba University,
3
Faculty of Pharmaceutical Sciences, Toho University)

P-094

Kinetic study of the methylation of glutathione persulfide by thiopurine
S-methyltransferase◯ Momoka Uchida1, Yasunori Fukumoto2, Yoshikazu Yamagishi3 ,Yu-ki Tanaka2,
Noriyuki Suzuki4, Yasumitsu Ogra2(1Fac. Pharm. Sci., 2Grad. Sch. Pharm. Sci., 3Grad. Sch. Med., Chiba Univ,
4
Fac. Pharm. Sci., Toho Univ.)

P-095

Effect of oleanolic acid on lipid metabolism in mice fed a high-fat diet
◯ Tohru Yamazaki, Rieko Ueda, Haruna Hachikawa, Haruka Noda, Kaoruko Endo,
Atsushi Mitsumoto(Fac. Pharm. Sci., Josai International Univ.)

P-096

Extracellular ATP Suppresses the Expression of Heparan Sulfate Proteoglycan
Perlecan in Vascular Endothelial Cells via the P2Y2R-Akt Signaling Pathway◯ Lihito Ikeuchi1, Tsuyoshi Nakano2, Takato Hara2, Kazuki Kitabatake1,
Chika Yamamoto2, Mitsutoshi Tsukimoto1, Tomoya Fujie1, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. of Sci., 2Fac. Pharm. Sci., Toho Univ.)

P-097

A Pilot Test of Olive Weevil Repellents in an Olive Orchard◯ Atsushi Mitsumoto, Tohru Yamazaki(Fac. Pharm. Sci., Josai Intlʼ Univ.)

P-098

Mechanism of cold stress response in human hepatocarcinoma cells (HepG2)◯ Ayano Fukuda1, Yoshikazu Yamagishi2, Sayaka Nagasawa2,3, Yasumitsu Ogra2,3(1Graduate School of Medicine and Pharmaceutical Sciences,2
Graduate School of Medicine,
3
Graduate School of Pharmaceutical Sciences, Chiba University)−84−

P-099The core protein expression of proteoglycans does not reflect their mRNA levels in
cultured vascular endothelial cells under hypoxic conditions◯ Misaki Shirai1,2, Takato Hara1, Toshiyuki Kaji3, Chika Yamamoto3(1Fac. Pharm. Sci., Toho Univ, 2JSPS Research Fellow,
3Fac. Pharm. Sci., Tokyo Univ. Sci.)

P-100

Evaluation of specificity and capability of SPL2 protein for metal ions
◯ Li Enhui1, Yasunori Fukumoto2, Yu-Ki Tanaka2, Yasumitsu Ogra2（1Grad. Sch. Med & Pharm. Sci., 2Grad. Sch. Pharm. Sci., Chiba Univ.）

P-101

Effects of microplastics/nanoplastics with different surface properties and sizes on
microglia and astrocytes◯ Cai Zong1, Emi Kato1, Risa Tsuyuki1, Sonja Boland2, Yuki Kitamura3,
Sahoko Ichihara3, Gaku Ichihara1(1Faculty of Pharm. Sci., Tokyo Univ. of Sci.; 2Université Paris Cité, CNRS;
3
School of Med., Jichi Med. Univ.)

P-102

Analysis of structure-activity relationships and cell type-dependency for PFAS
toxicity in vascular endothelial cells◯ Sayori Ichijo, Toshiyuki Kaji, Tomoya Fujie(Fac. Pharm. Sci., Tokyo Univ. of Sci.)

P-103

Study of NF-κB activator/inhibitor detection method for screening of toxic
substances in textile products◯ Iwaki Nishi1, Taichi Yoshitomi1, Tsuyoshi Kawakami2(1 Kanagawa Prefectural Institute of Public Health, 2 NIHS)

P-104

Prediction of hTRPA1 activation by fragrance allergens regulated by the revised
EU cosmetics regulation◯ Yui Okino1, Miyu Takahashi1, Yoko Mori2, Susumu Ohkawara1, Yasuyuki Kitagawa1,
Noriyuki Kitagawa1, Takashi Isobe1, Nobumitsu Hanioka1, Hideto Jinno3,
Toshiko Tanaka-Kagawa1(1Yokohama Univ. Pharm., 2Natl. Inst. Health. Sci, 3Facul. Pharm., Meijo Univ.)

P-105

International standardization of Methods of Analysis in Health Science and theiradministrative utilization/application◯ Shinobu Sakai1, Shin-ichi Tanabe2, Kazuhide Ito3, Maiko Tahara1,
Toshiko Tanaka-Kagawa4, Hideto Jinno5(1NIHS, 2Waseda Univ.,3Kyushu Univ.,4Yokohama Univ. Pharm.,5Meijo Univ.)−85−

P-106

Species differences in TRPA1 activation by the alternative plasticizers to phthalates◯ Ryuto Yuasa1, Yoko Mori2, Akira Aoki1, Yoshinori Okamoto1, Takashi Isobe3,
Susumu Ohkawara3, Nobumitsu Hanioka3, Toshiko Tanaka-Kagawa3, Hideto Jinno1(1 Faculty of Pharmacy, Meijo University, 2National Institute of Health Sciences,
3
Yokohama University of Pharmacy)

P-107

Effects of drugs with reported immune-mediated disorder on Dendritic Cellimmune responses◯ Kazuki Sasano1, Satoshi Ishikawa2, Haruka Mizuno1, Kanon Murase1, Isamu Ogawa2
Saotomo Itoh2, Shinsuke Taki3, Shigeaki Hida2(1Fac. Pharmaceut. Sci. Nagoya-City Univ.,
2
Grad. Sch. Pharmaceut. Sci. Nagoya-City Univ., 3Sch. Med, Shinshu Univ)

P-108

Examination of the suppressive effect of Indian mulberry (noni) juice on the AGEs
formation caused by glycation of albumin and collagen◯ Masaki Takaishi1, Miharu Fukasawa1, Ichiro Kawano2, Sayoko Nishioka3,
Akio Kobayashi1, Satoshi Asano4(1Pharm. Sci., IUHW., 2MARURU, 3Pharmakion Plan., 4FSC.)

P-109

Analysis of SARS-CoV-2 isolated from the persistent COVID-19 patient◯ Hiroki Futatsusako1, Rina Hashimoto1, Masaki Yamamoto2, Jumpei Ito3,
Yasufumi Matsumura2, Genotype to Phenotype Japan (G2P-Japan) Consortium,
Kei Sato3, Miki Nagao2, Kazuo Takayama1（1CiRA, Kyoto Univ., 2Grad. Sch. of Med., Kyoto Univ.,
3
The Inst. of Med. Sci., The Univ. of Tokyo.）

P-110

Functional analysis of amino acid transporter SLC6A19 in placenta◯ Momoe Serizawa1, Kazuma Higashisaka1,2,3, Yurina Nakamoto1, Rena Yamamoto1,
Yuya Haga1,3, Yasuo Tsutsumi1,3,4,5（1Sch. Pharm. Sci., Osaka Univ., 2IACS., Osaka Univ.,
3
Grad. Sch. Pharm. Sci., Osaka Univ., 4MEI Ctr., Osaka Univ., 5OTRI., Osaka Univ.）

P-111

Evaluation of placental transmission of plastic nanoparticles◯ Mizuki Muranaka1, Kazuma Higashisaka1,2,3, Jundai Kobayashi3, Yankun Xie3,
Wakako Okuno1, Yuya Haga1,3, Yasuo Tsutsumi1,3,4,5(1Sch. Pharm. Sci., Osaka Univ., 2IACS., Osaka Univ.,
3
Grad. Sch. Pharm. Sci., Osaka Univ., 4MEI Ctr, Osaka Univ., 5OTRI., Osaka Univ.)

P-112

Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces the growth
retardation in postnatal offspring: transgenerational toxicity and the restorationby aripiprazole intervention◯ Xing Zou1, Ming Yuan1, Tomoki Takeda1,2, Yoshitaka Tanaka1, Yuji Ishii1（1Grad Sch Pharmaceuti Sci., Kyushu Univ., 2F-SEEDS）−86−

P-113

Application of the dihydropyrazine for prevention and treatment of sepsis:therapeutic effect in multiple organs◯ Madoka Sawai1, Yutaka Tatano1, Katsuya Miyake3, Jian-Rong Zhou2, Taku Kaitsuka1,
Hisao Kansui2, Yuu Miyauchi2, Shinji Takechi2(1Sch. Pharm., at Fukuoka. Int. Univ. Health & Welfare.,2
Fac. Pharmaceut. Sci., Sojo Univ., 3Cbmr., at Narita. Int. Univ. Health & Welfare.)P-114

Molecular and structural change of macrophages in mammary papilla of lactating
female mice
◯ Yukiko Marunaka, Kei Nakayama, Hiroshi Hasegawa(Lab. Hygienic. Sci., Kobe Pharm. Univ.)

P-115

Elucidation of the anti-inflammatory mechanisms of the cephem antibiotics◯ Sara Suzuki, Tomohiro Kagi, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-116

Novel induction mechanisms of Smac-independent apoptosis induced by the antitumor kinase LKB1
◯ Maki Mitsuya, Yutaro Yamada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa((Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-117

Conjugated fatty acids (CFAs) induce ferroptosis by promoting degradation of
GPX4 through chaperone-mediated autophagy◯ Soma Taguchi, Yusuke Hirata, Ryota Kojima, Shinnosuke Kimura,
Haruka Masumoto, Takuya Niijima, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-118

The regulatory mechanism of TRIM48, a positive regulator of ASK1, throughubiquitination-dependent degradation and its role in oxidative stress responses◯ Haruka Masumoto, Naoki Kashiwabara, Yusuke Hirata, Takuya Noguchi,
Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)−87−