27 Nov. 2013

Laboratory for Function Chemistry

http://www.sci.osaka-cu.ac.jp/chem/aa/aa.pdf
Current Research and Principal Research Interests
Selected Original Papers (2006-2011)
Journal Cover Gallery

1. Current Research and Principal Research Interests
Our research interests all come under the general heading of "Molecular Recognition
Chemistry", "Coordination Chemistry", and "Supramolecular Chemistry". The actual research
projects range from inorganic, organic, analytical, and biological chemistry to integrated
systems chemistry.
Recent Reviews:1) S. Shinoda and H. Tsukube, Chem. Sci., in press. DOI:10.1039/c1sc00162k. 2) S. Shinoda
and H. Tsukube, Analyst, 136, 431-435 (2011). 3) H. Sugimoto and H. Tsukube, Chem. Soc.
Rev., 37, 2609-2619 (2008). 4) S. Mameri, S. Shinoda, and H. Tsukube, Heterocyclic
Supramolecules I (Series: Topics in Heterocyclic Chemistry, Vol. 17), Springer-Verlag, pp.
1-42, (2008).
(1) Molecular Recognition & Coordination Chemistry
In the synthetic approaches to the artificial receptors which should be highly specific, verystrong complexing agents, various types of lanthanide complexes were designed to offer thesophisticated molecular recognition and subsequent refined functions. Based on their uniquecoordination and molecular recognition chemistry, efficient chirality sensing and selectiveluminescence detection systems were developed in our research group.

"Lanthanide Complexes" Specific for Luminescence Sensing: Several series of lanthanide
complexes were successfully developed as new specific luminescent probes, which werecharacterized by chromophoric synthetic ligands and luminescent lanthanide centers. Inorganic
anions, amino acids, dipeptides and other bio-targets were specifically sensed by monitoring thevisible and near-infrared lanthanide luminescence.
"Lanthanide-Substituted Proteins" as Specific Bio-Tools: Luminescent lanthanide centerswere combined with biological proteins such as transferrin and ferritin to provide nano-scale
molecular recognition and luminescence sensing phenomena. Proper combinations of lanthanide
centers and structured protein ligands led to a novel family of specific bio-tools for wide
applications.

(2) Supramolecular Chemistry toward Systems Chemistry:The supramolecular approaches
were extensively investigated on the basis of molecular recognition and coordination chemistry,which provided promising possibilities in creating new functional chemical systems atnano-meter levels.
"Functional Integration" on Supramolecular Assembly: Chiral cholesterol-armed cyclen –metal complexes were demonstrated to have unique quadruplicated helical geometry and toform chiral supramolecular vesicles in the aqueous solutions and monolayer membranes at theair-water interfaces. They offered enantiomer-selective amino acid inclusion and precise
recognition of thymine derivatives.

"Chemical Switching with Labile Metal Complexes": Several labile metal complexes including
armed cyclen-Ca2+complexes, synthetic peptide-Co2+ complexes, and trivalent lanthanidecomplexes well worked as dynamic molecular switches. They quickly responded H+, anion,
electron and other external stimuli and dynamically altered the three-dimensional structures andchemical functions of the molecular systems.

2. Selected Original Papers (2006-2011)
1. Mixed-Metal Complexes Incorporating Platinum and Lanthanide Centers for SelectiveBinding and Chirality Sensing of Succinates, S. Shinoda, A. Mizote, M. Eiraku Masaki, M.
Yoneda, H. Miyake, and H. Tsukube, Inorg. Chem., 50, 5876-5878 (2011).
2. Mechanical Tuning of Molecular Recognition to Discriminate the Single-Methyl-Group
Difference between Thymine and Uracil, T. Mori, K. Okamoto, H. Endo, J. P. Hill, S. Shinoda,
M. Matsukura, H. Tsukube, Y. Suzuki, Y. Kanekiyo, and K. Ariga, J. Am. Chem. Soc., 132,
12868-12870 (2010).
3. Poly(arginine)-Selective Coprecipitation Properties of Self-Assembling Apoferritin and Its
Tb3+ Complex: A New Luminescent Biotool for Sensing of Poly(arginine) and Its Protein
Conjugates, H. Tsukube, Y. Noda, and S. Shinoda, Chem.–Eur. J., 16, 4273-4278 (2010).
4. Asymmetric Twisting and Chirality Probing Properties of Quadruple-Stranded Helicates:

Coordination Versatility and Chirality Response of Na+, Ca2+, and La3+ Complexes withOctadentate Cyclen Ligand, H. Misaki, H. Miyake, S. Shinoda, and H. Tsukube, Inorg. Chem.,
48, 11921-11928 (2009).
5. Chemical Device Exhibiting Dual Mode Motions: Dynamic Coupling of Amide Coordination
Isomerism and Metal-Centered Helicity Inversion in Chiral Cobalt(II) Complex, H. Miyake, M.
Hikita, M. Itazaki, H. Nakazawa, H. Sugimoto, and H. Tsukube, Chem.–Eur. J., 14, 5393-5396(2008).
6. Experimental and Theoretical Approaches Toward Anion-Responsive Tripod–Lanthanide
Complexes: Mixed Donor Ligand Effects on Lanthanide Complexation and Luminescence
Sensing Profiles, Y. Kataoka, D. Paul, H. Miyake, T. Yaita, E. Miyoshi, H. Mori, S. Tsukamoto,H. Tatewaki, S. Shinoda, and H. Tsukube, Chem.–Eur. J., 14, 5258-5266 (2008).
7. Time-Programmed Peptide Helix Inversion of Synthetic Metal Complex Triggered by Achiral
NO3– Anion, H. Miyake, H. Kamon, I. Miyahara, H. Sugimoto, H. Tsukube, J. Am. Chem.
Soc., 130, 792-793 (2008).
8. "Pocket Dendrimers" as Nanoscale Receptors for Bimolecular Guest Accommodation, S.
Shinoda, M. Ohashi, and H. Tsukube, Chem.–Eur. J., 13, 81-89 (2007).
9. Mechanical Control of Enantioselectivity of Amino Acid Recognition by Cholesterol-Armed
Cyclen Monolayer at the Air-Water Interface, T. Michinobu, S. Shinoda, T. Nakanishi, J. P. Hill,
K. Fujii, T. N. Player, H. Tsukube, and K. Ariga, J. Am. Chem. Soc., 128, 14478-14479 (2006).
10. Reversible Sulfurization-Desulfurization of Tungsten-Bis(dithiolene) Complexes, H.
Sugimoto, R. Tajima, T. Sakurai, H. Ohi, H. Miyake, S. Itoh, and H. Tsukube, Angew. Chem.
Int. Ed., 45, 3520-3522 (2006).
3. Journal Cover Gallery

Analyst 2011

Chem. Soc.
Rev. 2008

Dalton Trans.
2007

Chem. Rev.
2002