3!"#$%&'()*+,-./0.123456789
:;<=>  ?@A.<B

!CDEF  GHIJ

 KLMN "#$%& '()* (OHFWURQ7UDQVIHU(7 +,-./012'(3456.78 (/ 9:;<9=>?,@ABCDE9FG+,?HCI(7 +,-.JKLMN9+,?HO.PQNR 0DUFXVS$RTUVWXBCIYZY.[B\?](FG?-^MN9'(_`ZabcNRWXBV
defgh.ij_`klmnoepqOWrhst?HUeI\e.uvwxyS$ 'HQVLW\)XQFWLRQDO7KHRU\')7 ?-.z{|}~@fm?d9rep.'h FYVY\r (7 +,mqOW[?d9rrhHCI.:X a-.HCR'(mFACuvwxyS$ &RQVWUDLQHG')7&')7 mY.(7 +,RrVcLMN
9'(_`mW[mRYe>@IJ?-.N9 ¡¢£f¤ ¥¦§¨©
£Rª«C=(¬ (7­®¯°>@m±YV.&')7 m@rVLMN9'(_`m²p.0DUFXVS$R³UV´vµyf¶·mYeI
OO
CHCH


H C
H C

O-O


® & EEGLK\GUREEGLPHWK\OLQGHQR>D@LQGHQHGLRQH ¤ ¥¦§¨©£f=(¬(7& "kl¸¹%±f (7 +,RrV.ºf´vµym 0DUFXV S$R³O¶·YeI[[?.
ÀÁÂÃÄ¦ÅÆǌ ª³Ç'(¥ÈÉÊ£ËÌÍEÎ +DE´vµy N m»µ¼«C½¾7f¿(.
-.&')7 R³O (7 ÏÐRª«CLMN9'(_`mÑÒÓC[?cNRklYeIeg
Y.[[?-.& ÔÇ & ÕÖ- 8+)* G ×ØFÕÖm@r.&')7%/<3* GR³CÃÄ¦ÅÆPklmÌUeI&')7 kl-.®  RÙYe  fm@r.'RPDLQ&  'RPDLQ&·fb? (7 hj[C[mÚµYeI[Bafkl-ÛÜ?Ye ')7 ÉÝË¤ÞR &')7 klßÆàmáâYVÌUeI
33

3

Domain C'

3

Domain C'O

Domain C'
OCH3OCH3

H3C

CH3

H3C-O

scheme 1

Domain C

H3C-O

Domain C

scheme 2-Oscheme 3Domain C® & &')7 klRª«C"klã%& ä  R &')7 R³Ckl?²paBeå VFKHPH ?f.& ÕÖ & ÕÖfÃÄ¦ÅÆæç( 6è£éêë6!!0DUFXV ì¤íÆî?HCïFzðÃÄ¦ÅÆç*Â.ǌ.+DEª³Ç.0DUFXV S$Za²pe´vµy N m\peIǌ RrVñVñC.å 6FKHPH òóôëRõöV÷A9ëmÙYeI[B-.óô?øaBC ǌ hùúfÀÁÂÃÄ¦ÅÆmnû
?rCfRY.Jkl?øaBCë-±=(fÀÁÂÃÄ¦ÅÆfñmüýYVrCepgüþaBCI\e.N RrVñC. f VFKHPH fÿ?-×òóôëRrëmÙYeI
YZY.ÓöVf VFKHPH ?óôëRõö R!d9ëmÙYVrCI[B-óôhùúÿ?

ÌXBVrCfRY.kl-"|ÿ?ÌXBVrCepgüþaBCIÌXBVrCfRY.kl¡¢£§¨©£Rª«CAB¦ÃÄ¦ÅÆ(®  -.VFKHPH ?f ¡¢£§¨©£Rª«C=(¬(7 +,f?@£AB#m 0DUFXV S$R$¼rV%%reòf?HCI[[?.T   T  RªrVºBEB
RªrVºB&.
& ÕÖmUVrCI&Kf ')7 kl?-.^MN9(#høaB.½-+,+,FG TJ RªrV×ò'µFYVrCep (7 +,½YVW[h?d9rIP¸.&')7&')7 klZa-L
MN9(#høaB.[f(#)(#)Za.å 0DUFXV ì¤íÆîm²pC[h?dCIì¤íÆîm²pC[h?dCIä  R-.®  R*+,-mÙYemÙYe.Î/(f012ã0µy +)&& m\peI&')7m\peIkl?-.6!fëh  R3.R3DH_`fIYVØÛ?HCrþCI[BmñC.
YVØÛ?HCrþCI[BmñC.
:f VFKHPH òµNRHCÐvóôëRrëmÙYVrC[hXZCIYZY.$òµNRHCÐvóôëRrëmÙYVrC[hXZCIYZY. ?fë
f³R!d34BVrC56
56òHO.78ùúmnpeklmÌ[?
ùúmnpeklmÌ[?9:ÓC[héêABCI\e.6è£h\e.6è£h FYe?f6è£=;hFYe?f6è£= h N?HC[Za.[f (7+,-<¤ ¥¦f (7 +,?HC=>ABCI
+,?HCä  å VFKHPH ?fÃÄ¦ÅÆæÔÇ?fÃÄ¦ÅÆæÔÇ 6!!0DUFXV ì¤íÆî.´vµy&& &')7 %/<3 )"#(N-PRO 6!ǌ

ç*Â+DEN V &&N-PRO $ VFKHPHð

$ VFKHPHð

$ VFKHPHð

([SWO>@

ð



O

8

97CH31
2

6
5

H3C

103-

O4

® VFKHPH ?f?@£AB¦ÃÄ¦ÅÆ¦ÃÄ¦ÅÆ(#& & & & & ®  ä  Rª«C.
.Î/(f*+,-ä & & ÕÖ?f +)&& JDXVV & &')7%/<3 )" 
$%&%'%(%(%*%+%,%-%.%/0123%/0123

%&40123

6FKHPH

6FKHPH 

6FKHPH 

H[SWO>@




"*üCD%>@4:X799RRUKLV3K\V5HY$
3K\V5HY   >@++RVRL<0DVXGD-0RO/LT-0RO/LT   