Commitment & Credibility since 1976
Memorandum
Date: September 15th, 2023
From: Bart Heldreth, Ph.D., Executive Director, Cosmetic Ingredient Review
To:All Stakeholders

Re:2024 Final Priority List

There are 18 reports proposed, covering 31 ingredients, on the 2024 Final Priorities List. While thepriority list includes only the lead ingredients, groupings of ingredients for reports can be found on
the following pages. Reports previously prioritized and on the CIR docket at the end of 2023, as
well as an extensive number of re-reviews of previous assessments, will supplement the total numberof reports/ingredients to be assessed in 2024. Interested parties are encouraged to submit pertinent
data to the CIR, as soon as possible, for use in the development of the Scientific Literature Reviews(SLR) for these ingredients. Although the specific data needs vary for each safety assessment, thefollowing are typical data that the Panel reviews for each safety assessment.
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Chemistry, impurities, and method of manufacture
Risk (e.g., margins of safety)
Toxicokinetics data, specifically dermal absorption and/or penetration
Repeated-dose toxicity data
Inhalation toxicity data, if the ingredient is used in a product that can be incidentally inhaled
Reproductive/developmental toxicity data
Genotoxicity data; if positive, carcinogenicity data may be needed
Dermal irritation and sensitization data at maximum concentration of use

For the review of botanical ingredients (natural complex substances (NCS)), the additional dataneeded include: species, plant part, extraction method, solvent, and data on component chemicalcharacterization. It is important that these data are specific for the ingredient(s) as used incosmetics.

1620 L Street, NW Suite 1200, Washington, DC 20036(Email) cirinfo@cir‐safety.org (CIR website) www.cir‐safety.org(Panel website) ingredientsafetyexpertpanel.org

2024 Final Priorities List
IngredientFrequency of Use (FOU)
Data Year: 2023

For cause
Cannabidiol
Basic Blue 7
Trimethylbenzoyl Diphenylphosphine Oxide
Tetrabromophenol Blue

32
1127
2Per FOU
Polyacrylate‐13
Polygonum Cuspidatum Root Extract
Xylitylglucoside
Phytosphingosine
Sodium Hyaluronate Crosspolymer
Polyacrylate Crosspolymer‐6
Trimethylpentanediyl Dibenzoate
Tosylamide/Epoxy ResinCarnosine
Madecassoside
Sophora Flavescens Root Extract
Curcuma Longa (Turmeric) Root Extract
Lonicera Japonica (Japanese Honeysuckle) Flower Extract
Perfluorohexylethyl Triethoxysilane

265245
213
210
207
205
202
189
184
182
179
177
175
172

2|Page2024 Final Priorities Groupings for New Reports
Planned 2024 Reports – per cause

Cannabidiol – Previously proposed for Panel review by FDA
Cannabidiol (CBD)FOU = 32

Definition: Cannabidiol is the organic compound that conforms to the structure:

Reported Functions: Antiacne Agents; Antioxidants; Drug Astringents ‐ Skin Protectant Drugs; SkinProtectants; Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS No. 13956‐29‐1) At a previous meeting, a liaison from the FDA proposed that the Panelassess the safety of Cannabidiol (CBD). At that time, there were zero formulations reported to the VCRP
containing cannabinoid ingredients; accordingly, the Panel chose to defer review.
Grouping proposal: None

Basic Blue 7 – on EU Annex II – forbidden from use in cosmetics

FOU = 1

Definition: Basic Blue 7 is classed chemically as a triarylmethane color. It
conforms to the structure:

Reported Function: Hair ColorantNotes: (CAS No. 2390‐60‐5) on EU Annex II – forbidden from use in cosmetics
Grouping proposal: None3|PageTrimethylbenzoyl Diphenylphosphine Oxide – FDA request

FOU = 127

Definition: Trimethylbenzoyl Diphenylphosphine Oxide is the organic compoundthat conforms to the structure:

Reported Function: Skin Conditioning Agent
Notes: ECHA launched a 45‐d consultation for their plan for Diphenyl(2,4,6‐trimethylbenzoyl)phosphineoxide (Trimethylbenzoyl Diphenylphosphine Oxide) to be added to the substances of very high concern(SVHC) list on February 17, 2023. There are new DART concerns.
Grouping proposal: None

Tetrabromophenol Blue – SCCS insufficient data

FOU = 2Definition: Tetrabromophenol Blue is the organic compound that conforms to thestructure:

Reported Function: Hair ColorantNotes: (CAS No. 4430‐25‐5) There is a 2019 SCCS opinion (https://health.ec.europa.eu/system/files/2021‐08/sccs_o_232_0.pdf) with a conclusion of safe when used as a hair dye in oxidative and non‐oxidative
hair coloring products at a final on‐head concentration of up to 0.2%. Tetrabromophenol Blue has also
been added to EU Annex III (entry 319) with the limitations recommended by the SCCS in 2019.
Grouping proposal: None4|PagePlanned 2024 Reports – per FOU

Polyacrylate‐13

FOU = 265

Definition: Polyacrylate-13 is the copolymer of acrylic acid, acrylamide, sodium acrylate, and sodium
acryloyldimethyltaurate monomers.

Reported Function: Film Formers
Notes: The Panel has previously assessed the safety of structurally similar ingredients in the Safety
Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics, finalized in 2017 (e.g.,Acrylamide/Sodium Acryloyldimethyltaurate/Acrylic Acid Copolymer, defined as: a copolymer ofacrylamide, sodium acryloyldimethyltaurate, and acrylic acid monomers), concluding that suchcopolymers are safe as used.
Grouping proposal: NonePolygonum Cuspidatum Root Extract

FOU = 245

Definition: Polygonum Cuspidatum Root Extract is the extract of the roots of Polygonum cuspidatum. The
accepted scientific name for Polygonum cuspidatum is Fallopia japonica.

Reported Functions: Antioxidants; Skin‐Conditioning Agents – MiscellaneousNotes: These 2 botanical ingredients are derived from the same plant species, 1 from the root and theother from the whole plant.
CIR draft grouping/clustering: (2 ingredients proposed with a total FOU = 245)
Polygonum Cuspidatum Root Extract
Polygonum Cuspidatum Extract

Xylitylglucoside

FOU245‐FOU = 213

Definition: Xylitylglucoside is the organic compound that conforms to the structure:

Reported Functions: Skin‐Conditioning Agents ‐ Humectant
Notes: (CAS No. 1095751‐96‐4)
CIR draft grouping: None5|Page

FOU = 210

Phytosphingosine

Definition: Phytosphingosine is a synthetic sphingolipid that conforms generally to the structure:

Reported Functions: Hair Conditioning Agents; Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS Nos. 554-62-1; 13552-11-9) The Panel has previously assessed the safety of structurally-related
ingredients in the Safety Assessment of Ceramides as Used in Cosmetics, published in IJT in 2020 (e.g., Caprooyl
Phytosphingosine, defined as: the product obtained by the reaction of Caproic Acid and Phytosphingosine),
concluding that such copolymers are safe as used. While Phytosphingosine contains a free amine functional group,
the ceramides differ as corresponding amides.

CIR draft grouping: (4 ingredients proposed with a total FOU = 233)
Phytosphingosine
Tetraacetylphytosphingosine
Acetylphytosphingosine
Phytosphingosine HCl

Sodium Hyaluronate Crosspolymer

FOU2101742FOU = 207

Definition: Sodium Hyaluronate Crosspolymer is the sodium salt of a polymer of Hyaluronic Acidcrosslinked with divinyl sulfone.

wherein R is hydrogen or sodium

Reported Functions: Skin‐Conditioning Agents – Humectant; Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS No. 105524‐32‐1) These 3 ingredients share the same polyhyaluronate backbone and differ
only by the crosslinker (diglycidyl ether for Sodium Hyaluronate Crosspolymer‐2 and propylbisoxyaminefor Sodium Hyaluronate Crosspolymer‐3). (The Panel has recently addressed the safety of SodiumHyaluronate.)
CIR draft grouping: (3 ingredients proposed with a total FOU = 210)
FOU
Sodium Hyaluronate Crosspolymer
207
Sodium Hyaluronate Crosspolymer‐2
2Sodium Hyaluronate Crosspolymer‐3
16|PageFOU = 205

Polyacrylate Crosspolymer‐6

Definition: Polyacrylate Crosspolymer-6 is a copolymer of ammonium AMPS (2-acrylamido-2-methylpropane
sulfonic acid), dimethylacrylamide, lauryl methacrylate, and laureth-4 methacrylate, crosslinked withtrimethylolpropane triacrylate.

Reported Functions: Emulsion Stabilizers; Viscosity Increasing Agents ‐ Aqueous
Notes:
CIR draft grouping: none

Trimethylpentanediyl Dibenzoate

FOU = 202

Definition: Trimethylpentanediyl Dibenzoate is the organic compound that conforms to the structure:

Reported Functions: Plasticizers
Notes: (CAS No. 68052‐23‐3)
CIR draft grouping: none
FOU = 189

Tosylamide/Epoxy Resin

Definition: Tosylamide/Epoxy Resin is the toluenesulfonamide of the condensation product of 4,4'isopropylidenediphenol/epichlorohydrin copolymer, also known as the epoxy resin. The polymeric endproduct conforms generally to the structure:

wherein n = 0 to 5

Reported Functions: Dispersing Agents – Nonsurfactant; Film Formers; Plasticizers
Notes: According to chemical structure, minimum molecular weight is 1012 Da.
CIR draft grouping: none

7|PageCarnosine

FOU = 184

Definition: Carnosine is the heterocyclic amine that conforms to the structure:

Reported Functions: Skin‐Conditioning Agents ‐ Miscellaneous
Notes: (CAS No. 305‐84‐0)
CIR draft grouping: None

Madecassoside

FOU = 182

Definition: Madecassoside is the organic compound that conforms to the structure:

Reported Function: Antioxidants; Skin Protectants; Skin‐Conditioning Agents ‐ Miscellaneous
Notes: (CAS No. 34540‐22‐2)
Grouping proposal: NoneSophora Flavescens Root Extract

FOU = 179

Definition: Sophora Flavescens Root Extract is the extract of the roots of Sophora flavescens.

Reported Functions: Antioxidants; Skin‐Conditioning Agents – Miscellaneous
Notes: These 3 botanical ingredients are each from the same species, Sophora flavescens, sometimes
referred to as shrubby sophora. Of these 3, 2 ingredients are derived from the root, and the other isderived from the whole plant.
FOU
CIR draft grouping: (3 ingredients proposed with a total FOU = 220)
179
Sophora Flavescens Root Extract
40
Sophora Flavescens Extract
1
Sophora Flavescens Root Powder

8|PageCurcuma Longa (Turmeric) Root Extract

FOU = 177

Definition: Curcuma Longa (Turmeric) Root Extract is the extract of the roots of Curcuma longa.

Reported Functions: Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS No. 84775‐52‐0) The ingredients in this group are each derived from the same species.
CIR draft grouping: (5 ingredients proposed with a total FOU = 220)
FOU
Curcuma Longa (Turmeric) Root Extract
177
Curcuma Longa (Turmeric) Root Oil
17
Curcuma Longa (Turmeric) Root Powder
15
Curcuma Longa (Turmeric) Rhizome Extract
6
Curcuma Longa (Turmeric) Leaf Extract
5Lonicera Japonica (Honeysuckle) Flower Extract

FOU = 175

Definition: Lonicera Japonica (Honeysuckle) Flower Extract is the extract of the flowers of Lonicera
japonica.

Reported Functions: Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS No. 223749‐79‐9 (generic)) The ingredients in this group are each derived from the same
species (also known as Japanese Honeysuckle).
CIR draft grouping: (2 ingredients proposed with a total FOU = 180)
FOU
Lonicera Japonica (Honeysuckle) Flower Extract
175
Lonicera Japonica (Honeysuckle) Leaf Extract5

Perfluorohexylethyl Triethoxysilane

FOU = 172

Definition: Perfluorohexylethyl Triethoxysilane is the organic compound that conforms to the structure:

Reported Functions: Binders; Skin‐Conditioning Agents ‐ MiscellaneousNotes: (CAS No. 51851‐37‐7)
Grouping proposal: None

9|Page