Surgical Methods to Place a Novel Refillable Ocular Microelectromecha...

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Invest Ophthalmol Vis Sci 2007;48: E-Abstract 5791.
© 2007 ARVO

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Articles by Humayun, M. S.

Surgical Methods to Place a Novel Refillable Ocular Microelectromechanical System (MEMS)
Drug Delivery Device
S. Saati1, R. Lo2, P. Y. Li2, J. Shih3, Y. C. Tai3, E. Meng2, R. N. Agrawal1 and M. S. Humayun1
1

Doheny Eye Institute, keck School of Medicine,University of Southern California, Los Angeles, California
Viterbi School of Engineering, University of Southern California, Los Angeles, California
3California Institute of Technology, Pasadena, California
2

Commerical Relationships: S. Saati, Bausch & Lomb, P; R. Lo, Bausch & Lomb, P; P.Y. Li, Bausch & Lomb, P; J. Shih, Bausch & Lomb, P; Y.C. Tai,Bausch & Lomb, P; E. Meng, Bausch & Lomb, P; R.N. Agrawal, Bausch & Lomb, P; M.S. Humayun, Bausch & Lomb, P.
Support: Bausch & Lomb Inc ,NSF Grant EEC 0310723(BMES-ERC)

Abstract
Purpose:Drug therapy plays a major role in ocular disease management. Current routes of ocular treatment (topical, systemic or intraocular injections) have
limited effects due to physiologic barriers and potential side effects. To circumvent these issues, a new refillable ocular MEMS drug delivery device has beendeveloped that will provide controlled intraocular drug delivery with potentially fewer side effects.
Methods:First generation devices are manually and electrically-controlled. The manually-controlled device, composed of a refillable reservoir, cannula andcheck-valve, is constructed of molded silicone. A one-way check-valve is integrated at the cannula tip to prevent backflow. The reservoir is sutured to thesclera, with the cannula entering the anterior chamber through a scleral tunnel incision. Drug dispensation occurs with pressure on reservoir. Dye was used
initially to visualize delivery, while later phenylephrine provided physiological evidence of ocular drug effect in vivo. Under controlled lighting, baseline
pupillary diameter was recorded. Changes were noted after phenylephrine dispensation. Left eye acted as control. The device was repeatedly dispensed andrefilled via 30g needle through the side wall. The electrically-controlled device consists of a reservoir, cannula and electrolysis pump on a silicon base. Dyewas dispensed in to the eye due to pressure of accumulated gas in the reservoir.
Results:Both devices dispensed dye into the porcine eye under test conditions. In the phenylephrine in vivo test, pupillary diameter increased by 1.5 mm afterdispensation. Repeated refilling of the device showed no functional damage. Check-valve successfully functioned with repeated dispensation.
Conclusions:This new MEMS drug delivery device with refillable reservoir and controlled release of drug may have potential advantages over current
methods of ocular treatment. Further experiments are needed to develop these devices .
Key Words: development • anterior chamber • drug toxicity/drug effects© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract inany form must be obtained in writing from the ARVO Office prior to publication.

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6/20/2007 1:07 PM