Product datasheet

CNQX, AMPA / kainate antagonist ab120017
72 References 画像数 3
医薬用外劇物

製品の概要
製品名

CNQX, AMPA / kainate antagonist

製品の詳細

AMPA / kainate antagonist

生理活性の詳細

Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycinesite.

CAS 番号115066-14-3

構造式

製品の特性
体系名

6-Cyano-7-nitroquinoxaline-2,3-dione

分子量232.16

分子式

C9H4N4O4PubChem 登録番号3721046

保存方法

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12months.

溶解性Soluble in DMSO to 100 mM

使用に関する注意Wherever possible, you should prepare and use solutions on the same day. However, if you need tomake up stock solutions in advance, we recommend that you store the solution as aliquots in tightly
sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior toopening the vial we recommend that you allow your product to equilibrate to room temperature for atleast 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions(FAQ) page for more details.

SMILES 線形表記

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

由来Synthetic1

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab120017の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション

特記事項

Abreviews

Functional Studies

Use at an assay dependent concentration.

画像

2D chemical structure image of ab120017, CNQX, AMPA / kainate
antagonist

Chemical Structure - CNQX, AMPA / kainate
antagonist (ab120017)

ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treatedwith CNQX (ab120017), by ICC/IF. Decrease in MEK1 (phosphoS298) expression correlates with increased concentration ofCNQX, as described in literature.
The cells were incubated at 37°C for 24h in media containing
different concentrations of ab120017 (CNQX) in DMSO, fixed with
4% formaldehyde for 10 minutes at room temperature and blockedwith PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and0.1% tween for 2h at room temperature. Staining of the treated cellswith ab96379 (1/100 dilution) was performed overnight at 4°C inPBS containing 1% BSA and 0.1% tween. A DyLight 488 goat antiImmunocytochemistry/ Immunofluorescence -rabbit polyclonal antibody (ab96899) at 1/250 dilution was used asCNQX, AMPA / kainate antagonist (ab120017)

the secondary antibody.

2

Left and Middle: Representative IOS amplitude map and field
response curve under control condition and under application of 20µM CNQX, respectively. The colorbar indicates the maximum
change of the transmittance compared to the resting light intensity.
A Right: Spatial visualization of the percentage of control changesof IOS signal caused by CNQX application.

Cellular activation - CNQX, AMPA / kainate
antagonist (ab120017)
Image from Ildiko P, et al. Plos One, 8(3), e57694. Fig4a,; doi: 110.1371/journal.pone.0057694

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Abcam biochemicals are novel compounds and we have not tested their biological activity in house. Please use the literature toidentify how to use these products effectively. If you require further assistance please contact the scientific support team3