分子生理学
論文
A 欧文A-a
1. Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du CK, Zhan DY, Nakao S, Machida N, Tanaka R, Yamane Y,Hayashi T, Kimura A: Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failureand conduction disturbance. American Journal of Physiology: Heart & Circulatory Physiology 314: H1192-H1202, 2018 (IF:3.569) ＊2. Gray B, Hasdemir C, Ingles J, Aiba T, Makita N, Probst V, Wilde AAM, Newbury-Ecob R, Sheppard MN, Semsarian C, Sy RW,Behr ER: Lack of genotype-phenotype correlation in Brugada Syndrome and Sudden Arrhythmic Death Syndrome families with
reported pathogenic SCN1B variants. Heart Rhythm 15: 1051-1057, 2018 (IF: 4.743) ＊3. Kozasa Y, Nakashima N, Ito M, Ishikawa T, Kimoto H, Ushijima K, Makita N, Takano M: HCN4 pacemaker channels attenuate
the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node. J Physiol 596: 809-825, 2018 (IF: 2.757)＊
4. Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N,Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S,Makita N, Shimizu W, Horie M, Kusano K: Clinical Manifestations and Long-Term Mortality in Lamin A/C Mutation Carriers
From a Japanese Multicenter Registry. Circ J 82: 2707-2714, 2018 (IF: 2.895) ＊5. Nakano Y, Ochi H, Sairaku A, Onohara Y, Tokuyama T, Motoda C, Matsumura H, Tomomori S, Amioka M, Hironobe N,
Ohkubo Y, Okamura S, Makita N, Yoshida Y, Chayama K, Kihara Y: HCN4 Gene Polymorphisms Are Associated With
Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation. Circ Genom Precis Med 11: e001980,
2018 (IF: 5.664) ＊6. Tsuji Y, Dobrev D: Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: mechanistic andtherapeutic considerations to reduce the risk of death. Int J Cardiol 255: 101-102, 2018 (IF: 4.034) ＊7. Tsuji Y, Dobrev D: Electrical storm: mechanistic and therapeutic considerations to avoid death in the survivors. J Thorac Dis 10:
S4053-S4056, 2018 (IF: 1.804) ＊A-e
1. Tsuji Y. CaMKII-mediated phosphorylation of sodium channel and arrhythmogenesis in a rabbit model of electrical storm. 2018
THRS Annual Conference in Conjunction with Tokyo-Taipei-Seoul Arrhythmia Joint Conference. 2018, Taipei.
2. Tsuji Y. Cellular and molecular mechanisms of electrical storm. 42nd ESC Working Group Cardiac Cellular Electrophysiology
Meeting. 2018, Essen.
3. Makita N. Genotype-Dependent Differences in Short QT Syndrome. The 11th Asia Pacific Heart Rhythm Society ScientificSession. 2018, Taipei.
4. Makita N. Atrial Conduction Defects Caused by a Connexin45 Mutation. The 11th Asia Pacific Heart Rhythm Society ScientificSession. 2018, Taipei.
5. Makita N. Novel Arrhythmia Syndrome Associated with Gap Junction Mutations. The 11th Asia Pacific Heart Rhythm Society
Scientific Session. 2018, Taipei.
6. Makita N. Clinical and Genetic Basis of Calmodulinopathy. The 11th Asia Pacific Heart Rhythm Society Scientific Session.
2018, Taipei.
7. Tsuji Y. Electrical storm associated with heart failure: life threatening challenge. The 11th Asia Pacific Heart Rhythm Society
Scientific Session. 2018, Taipei.
8. Tsuji Y. Late sodium current and ventricular arrhythmia. The 11th Asia Pacific Heart Rhythm Society Scientific Session. 2018,Taipei.
9. Gray B, Hasdemir C, Ingles J, Aiba T, Makita N, PROBST V, Wilde A, Semsarian C, Sy R, Behr E. Lack of genotype-phenotype
correlation In Brugada syndrome and sudden arrhythmic death syndrome families with reported pathogenic SCN1B variants. The
39th Heart Rhythm Society Scientific Sessions. 2018, Boston.
10. Kashiwa A, Aiba T, Makimoto H, Yamagata K, Keiko S, Yagihara N, Watanabe H, Ohno S, Hayashi K, Sumitomo N,Yoshinaga M, Morita H, Miyamoto Y, Makita N, Horie M, Yasuda S, Kusano K, Shimizu W,
The_Japanese_LQTS_registry_investigators. Mutation Hot-spot-based Risk Stratification In Long QT Syndrome Type 1: Data
From A Nationwide Japanese LQT Registry. The 39th Heart Rhythm Society Scientific Sessions 2018, Boston.
11. Tsuji Y, Yamazaki M, Niwa R, Tomii N, Arafune T, Honjo H, Dobrev D, Nattel S, Kodama I, Sakuma I, Makita N. Mechanisms
of Electrical Storm Associated With QT Prolongation: Successful Mapping of Torsades de Pointes in Rabbits. American Heart1

Association Annual Scientific Sessions 2018. 2018, Chicago.
12. Wijeyeratne Y, Tanck M, Batchvarov V, Muggenthaler M, Muir A, Schott J, Kyndt F, Bos J, Haglund-Turnquist C, Ohno S,Raju H, Veltmann C, Tester D, Pedrazzini M, Page S, Galvin J, Denjoy I, Crotti L, Horie M, Borggrefe M, Schwartz P,McKeown P, Sharma S, Shimizu W, Makita N, Roden D, PROBST V, Ackerman M, Aiba T, Behr E. Duration Predicts Events
In Caucasians With E1784K-SCN5A: The E1784K International Consortium. The 39th Heart Rhythm Society Scientific Sessions
2018, Boston.
13. Yamamoto Y, Makiyama T, Wuriyanghai Y, Kohjitani H, Hirose S, Gao J, Kashiwa A, Kimura T, Ishikawa T, Motomura H,Makita N, Ohno S, Chonabayashi K, Yoshida Y, Suda K, Horie M. Single Cell Electrophysiological Analysis of Human iPS
Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a MembraneVoltage Imaging System. The 11th Asia Pacific Heart Rhythm Society Scientific Session. 2018, Taipei.
14. Yamazaki M, Tsuji Y, Niwa R, Tomii N, Arafune T, Honjo H, Dobrev D, Nattel S, Kodama I, Sakuma I, Makita N. Torsadogenic
Action Of Late Na+ Current In Experimental Electrical Storm. The 39th Heart Rhythm Society Scientific Sessions. 2018, Boston.

B 邦文
B-b
1. 蒔田直昌. 心臓突然死の病態解明における最新の遺伝学研究―ゲノムワイド関連解析と次世代シークエンス解析―.
循環器内科 84: 699-704, 2018
2. 蒔田直昌. 家族性心房細動の遺伝子基盤. 心電図 38: 286-290, 2018
3. 石川泰輔, 蒔田直昌. 進行性心臓伝導障害の病態と遺伝的背景. 循環器内科 84: 721-728, 2018

B-c
1. 石川泰輔, 蒔田直昌. 循環器科の心電図

ECG for Cardiologists (ed 村川裕二) : 151－156, 2018

2. 辻幸臣, 蒔田直昌. 循環器内科専門医バイブル３ 不整脈 識る・診る・治す(eds 小室一成,平尾見三) : 33-42, 2018

B-e
1. Ishikawa T. Attempts to identify the genetic risk loci for the lethal arrhythmia in Japanese Brugada syndrome population. 第 1 回
日本循環器学会基礎研究フォーラム. 2018, 東京
2. Makita N. Pathophysiology of Inherited Arrhythmias Associated with Ca Handling Abnormality. The 65th Annual Meeting ofthe Japan Heart Rhythm Society. 2018, 東京3. Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Motoda C, Matsumura H, Tomomori S, Amioka M, Hironobe N,Ohkubo Y, Okamura S, Makita N, Yoshida Y, Chayama K, Kihara Y. HCN4 Polymorphisms and Tachycardia Induced
Cardiomyopathy The 65th Annual Meeting of the Japan Heart Rhythm Society. 2018, 東京
4. 辻幸臣, 蒔田直昌. CaMKII as a target for novel therapy to treat lethal ventricular tachyarrhythmias. 第 57 回日本生体医工学学会大会（旧日本エム・イー学会）. 2018, 札幌
5. Ishikawa T, Mishima H, Ohno S, T. A, Nakano Y, Aizawa Y, Nakajima T, Hayashi K, Murakoshi N, Yagihara N, Kimoto H,Makiyama T, Watanabe H, Morita H, Yoshiura K, Nogami A, Shimizu W, Horie M, Tanaka T, Makita N. Rare Coding Variantsin Genes Other Than SCN5A Are Minimal Genetic Burden on the Prognosis of Brugada Syndrome. The 65th Annual Meeting ofthe Japan Heart Rhythm Society. 2018, 東京
6. Ishikawa T, Seki A, Hagiwara N, Makita N. Cardiac Connexin Syndrome: A New Inherited Cardiac Conduction Disease Entitywith Distinct Electrophysiological and Extracardiac Manifestations. 第 82 回日本循環器学会学術大会. 2018, 大阪
7. Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I,Oginosawa Y, Nogami A, Aonuma K, Saitoh Y, Kimura T, Makita N, Shimizu W, Horie M, Kusano K. Clinical Manifestationsand Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry. The 65th Annual Meeting of
the Japan Heart Rhythm Society. 2018, 東京
8. 横井 文香 牧武, 山本 雄大, 張田 健志, Wuriyanghai Yimin, 早野 護, 西内 英, 糀谷 泰彦, 廣瀬 紗也子, 高 景山,大野 聖子, 豊田 太, 吉田 善紀, 蒔田 直昌, 堀江 稔, 木村 剛. CALM2 関連性 QT 延長症候群 iPSC モデルにおいて、l-cis-diltiazem は遅延した L 型 calcium チャネルの不活性化をさらに強める. 第 82 回日本循環器学会学術集会. 2018, 東京
9. 八木原 伸江 渡裕, 蒔田 直昌, 堀江 稔, 清水 渉, 大野 聖子, 長谷川 奏恵, 相庭 武司, 田中 敏博, 角田 達彦, 重水大智, 南野 徹. 不整脈症候群で心臓が構造的に正常な患者における心筋症の原因遺伝子変異の特定. 第 82 回日本循環器学会学術集会. 2018, 東京
10. Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T,Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T. The inactivation of L-type Ca2+ Channel wasimpaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation. 第 82 回日本循環器学会学術集会.
2018, 大阪2

11. 蒔田直昌. 徐脈性不整脈の遺伝子基盤. OSAKA Heart Rhythm Frontiers. 2018, 大阪
12. 辻幸臣. 巨大陰性 T 波に関わる基礎研究：電気的ストームを呈する完全房室ブロック家兎モデルと遅延 Na+電流. 第33 回犬山不整脈カンファレンス. 2018, 名古屋

教 室 等 名 ： 104 分 子 生 理 学 （ 生 理 学 第 一 ）研究業績集計表
論文数一覧
2018

A-a

A-bA-cA-dA-e

合計

SCI

B-a

B-bB-cB-dB-e

合計

総計

7000142170320121738

合計

総計1226

学会発表数一覧
A-a2018

合計

A-bｼﾝﾎﾟｼﾞｳﾑ

学会

66214B-aB-b
ｼﾝﾎﾟｼﾞｳﾑ

学会462

論文総数に係る教員生産係数一覧

2018

欧文論文総数
論文総数

教員生産係数（欧文論文）

SCI掲載論文数
欧文論文総数

教員生産係数（SCI掲載論文）

0.553

70.333

2.333

Impact factor 値一覧
2018

Impact factor

教員当たり Impact factor

論文当たり Impact factor

25.4668.489

3.6383