••••

目的：この研究は妊娠中・母乳中の母親の食事と児のアレルギー疾患との関係調査することである。
方法：2011 年 8 月までに出版された研究において母親の食事介入試験または妊娠中・授乳中の母親の食事と児のアレルギー発症（湿疹、喘息、花粉症、アレルギー感作）との関係について調べた。
結果： ４２の論文（ 4 万人以上）を検討した。 4 編は後視的コホート研究、1 編はケースコントロール研究であった。無作為コントロール試験において妊娠中の一般的な食物アレルゲンを除去した食事では児の湿疹、喘息の有症率に有意差はなかった。大規模な 前視的コホート研究でははあ帆やの食事と児のアレルギーとは殆ど有意差を認めなかった。大規模な 前視的コホート研究でははあ帆やの食事と児のアレルギーとは殆ど有意差を認めなかった。 . 果物、野菜、魚、ビタミンＤ豊富な食べ物や地中海食は児のアレルギー疾患リスクを僅かに下げた。野菜油、マーガリン、ナッツ、ファーストフードはアレルギーのハイリスクであった。
結論：このレヴューでは：このレヴューでは母親の食事と児のアレルギー疾患との関連を認
母親の食事と児のアレルギー疾患との関連を認めなかった。しかし母親の地中海食パターン（果物、野菜、ビタミンＤ。しかし母親の地中海食パターン（果物、野菜、ビタミンＤを含む食事）は有益である可能性があり、さらなる研究が必要である。
を含む食事）は有益である可能性があり、さらなる研究が必要である。

Nutrition. 2014 Nov-Dec;30(11-12):1225-41. doi: 10.1016/j.nut.2014.02.015. Epub 2014 Mar 12.

Does maternal diet during pregnancy and lactation affectoutcomes in offspring? A systematic review of food-based
approaches.
Netting MJ1, Middleton PF2, Makrides M3.

Author information
1
Child Nutrition Research Centre, Women's and Children's Health Research Institute,
North Adelaide, SA, Australia; School of Paediatrics and Reproductive Health, The
University of Adelaide, Adelaide, SA, Australia.
2
School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide,SA, Australia; ARCH: Australian Research Centre for Health of Women and Babies, TheRobinson Institute, The University of Adelaide, North Adelaide, SA, Australia.
3Child Nutrition Research Centre, Women's and Children's Health Research Institute,North Adelaide, SA, Australia; School of Paediatrics and Reproductive Health, The
University of Adelaide, Adelaide, SA, Australia; South Australian Health Medical
Research Institute, Adelaide, SA, Australia. Electronic address:maria.makrides@health.sa.gov.au.

Abstract
OBJECTIVES:
The aim of this study was to investigate the relationship between maternal diet during
pregnancy and lactation and development of atopic disorders in childhood.
METHODS:
We included studies published up to August 2011 that assessed food-based maternal
dietary interventions or that examined associations between maternal dietary intake

during pregnancy and/or lactation and allergic outcomes (eczema, asthma, hay fever,and sensitization) in their children.
RESULTS:We included 42 studies (>40 000 children): 11 intervention studies (including 7
randomized control trials), 26 prospective cohort studies, 4 retrospective cohort studies,and 1 case-control study. In the randomized control trials, no significant difference wasnoted overall in the prevalence of eczema and asthma in the offspring of women on diets
free from common food allergens during pregnancy. The prospective cohorts
investigated a large number of potential associations, but reported few significant
associations between maternal dietary intake and development of allergy. Maternal dietsrich in fruits and vegetables, fish, and foods containing vitamin D and Mediterranean
dietary patterns were among the few consistent associations with lower risk for allergic
disease in their children. Foods associated with higher risk included vegetable oils andmargarine, nuts, and fast food.
CONCLUSION:
This review did not find widespread or consistent links between mothers' dietary intake
and atopic outcomes in their children. However, maternal consumption of Mediterranean
dietary patterns, diets rich in fruits and vegetables, fish, and vitamin D-containing foods
were suggestive of benefit, requiring further evaluation.