General Information
Congress
Name

Joint International Symposium on TGF-β and Cancer
The 4th International Symposium by JSPS Core-to-Core Program“Cooperative International Framework in TGF-β Family Signaling”
Areas by MEXT “Integrative Research on Cancer Microenvironment Network”

Theme

TGF-β Family and cancer
Signal Network in Tumor Microenvironment

Date

January 12（Mon）- 13（Tue）, 2015

Venue

International Congress Center "EPOCHAL TSUKUBA"（Tsukuba, Ibaraki）
2-20-3 Takezono,Tukuba, Ibaraki 305-0032, Japan
TEL. +81-29-861-0001

OrganizerKohei Miyazono
Department of Molecular Pathology, Graduate School of Medicine, TheUniversity of Tokyo

Chairman

Mitsuyasu Kato
Department of Experimental Pathology, Faculty of Medicine, University ofTsukuba

Language

English（no simultaneous interpretation provided）

SponsorJapan Society for the Promotion of Science, Core-to-Core Program

AdmissionFree

BanquetTime: January 12（Mon）18:20 - 20:30
Place: International Congress Center EPOCHAL TSUKUBA "Espoir"

Homepage

http://www.c2ctgfb2015-4thsymposium.net

Joint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor Microenvironment

Access Map
Ibaraki Pref.

NOTE: Seats for the bus from
Tsukuba to Narita must be
reserved in advance.
Or call “Kanto-Tesudo,Tsukuba

About 45 minutes by The Tsukuba Express Train
About 80 minutes by highway express bus
About 100 minutes by Airport liner NATT'SNarita International Airport
Tokyo Metropolis

Akihabara
Tokyo

Tokyo International Airport(Haneda)

Chiba

29-822-5345).
Reservations are accepted up
to a month in advance, andno later than 7 P.M. on theprevious day.
Reservations are not necessary
for buses heading to Tsukuba,
or Haneda Airport.

From Haneda Airport

By taking a highway express bus
Board a highway express bus bound for Tsukuba Center (80 mins).
Bus route, timetable, and bus stops: http://hnd-bus.com/route/tsukubacenter.html
How to buy a ticket: http://hnd-bus.com/guide/ticket.html
NOTE:*2: Do not recommend the use during rush hours.
By taking Monorail + JR + Tsukuba Express Train
Board Tokyo Monorail at Haneda Airport Terminal 1 to Hamamatsu-Cho Station (20 mins).
“TX” for Tsukuba Express, located deep underground at the east side of the Akihabara station. It
takes about 5 mintes from JR(Akihabara Sta.) to TX on foot.
Board TX to Tsukuba Station Terminal (45 mins).
10 mins walk from Tsukuba Station.

From Narita Airport

Board the Airport liner NATT’S at the bus stop #8 in Terminal 1 (1stand get off at Tsukuba Center (100 mins).

AIRPORT LINER(NATT’S) /about 100 min.

About 10 min.
on foot

About 8 min.
on foot

Tsukuba International
Congress Center

Narita International Airport

Highway express bus Bus /about 80 min.

Tsukuba Center

Highway bus

Tokyo International Airport(Haneda)

Tsukuba
Sta.

TsukubaExpress Line

Akihabara Sta.

TsukubaExpress Train / about 45 min.

stNOTE: Seats for the bus from Tsukuba to Narita must be reserved in advance.
Reservations are accepted up to a month in advance, and no later than 7 P.M. on the previousday.
Reservations are not necessary for buses heading to Tsukuba, or Haneda Airport.

Access Map
To Mt.Tsukubs

To Mt.Tsukuba

Chuo Park

Tsukuba sta.

Tsukuba Center
CREO[JUSCO・SEIBU]

Chuo-dori

Okura Frontier Hotel Tsukuba

Nova Hall

Tsuchiura-Gakuen st.
Mitsu Bldg.

Oshimizu Park

Capio Hall
Supermarket
Okura Frontier Hotel Tsukuba EPOCHAL

convenience store

Takezono Park

Tukuba International
Congress Center

To Ushiku(To Sakura Tsuchiura I.C.
Pedestrian path )Walking Direction (From Tsukuba Center Bus Terminal / Tsukuba sta.)

For the Tsukuba International Congress Center
Please go up the escalator at Exit A3 to the pedestrian path and walk south approximately 800 m
along the path, which is about 8 mins walk.
For HOTEL TSUKUBA EPOCHAL
Almost the same direction above. You will see the hotel on your right just before the Tsukuba
International Congress Center.

Joint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor Microenvironment

Floor Map

1F
Main parking lot

P

EVMain Entrance

EV
Entrance

HOTEL TSUKUBA EPOCAL

Cloak
Infomation

Entrace Hall

Entrace

PC Checking Desk

Convention Hall300

Next Presenter’s Seat

PosterCompanyExhibition
Registration

EV3F*Banguet is held on the 3rd floor.

Instructions for Presenters and Chairpersons
Instruction for Chairpersons

Please be at the「Next Chairperson's Seat」10 minutes before your in-charged session starts.
Chairpersons are asked to remain within the time allocated for the session and each presentation.

Instruction for Oral Presenter• Allocated time for Oral Presentation
Session 1・Short talks

15 minutes for presentation, 5 minutes for discussion

Session 2・3・4・5・6・7

25 minutes for presentation, 5 minutes for discussion

Special Lecture

30 minutes for presentation, 10 minutes for discussion• Please visit the「PC Checking Desk」30 minutes before your session starts and be at the「NextPresenter’s Seat」10 minutes before your presentation starts.
• Please bring your own PC and AC adaptor for your presentation.
• The only type of connecter available at the venue is「Mini D-sub 15pin 3」. Please provide
your own connecter if your PC does not accept the Mini D-sub 15pin 3 type connecter.
• Presentation by using tablet terminator is not acceptable.
• For presenters who are not able to bring their own PC, PC will be prepared
the data are Power Point 2007/2010/2013.
Please save your data under your name.
• Please bring your own PC if your presentation includes Video (exclusive of Power Pointanimation function).
• Sound cannot be played.

Instruction for Poster Presenters• Posters should be displayed on the assigned board during the poster set-up time.
• Poster presenters should be ready in front of your poster panel
20cm
70cm
5 minutes before the session starts.
Title
20cm

Poster preparation• All poster presenters will be provided with 90 cm wide and210 cm high boards.
• Only English language is available.
• Presenters should prepare a header indicating or including

160cm• Presentation number of your poster, pins and ribbon will be
provided at the poster session area.
30cm

Poster NoAﬃliations
Name of authors

Body

Please do not display poster over here

Poster schedule
Poster Set-up

January 12 (Monday) 8:00~8:50

Poster Viewing1

January 12 (Monday) 10:40~11:40 (poster with odd number)

Poster Viewing2

January 12 (Monday) 15:10~16:10 (poster with even number)

Poster Award

January 12 (Monday) 18:20~20:30 (Banquet)

Poster Removal

January 13 (Tuesday) 15:40~16:00

Joint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor Microenvironment

Invited Speakers
Hiroyuki Aburatan（i Japan）
Shigeru Chiba（Japan）
Marie-José Goumans（the Netherlands）
Eiji Hara（Japan）
Beate Heissig（Japan）
Carl-Henrik Heldin（Sweden）
Mitsuyasu Kato（Japan）
Yoshihiro Kawasaki, Tetsu Akiyama（Japan）
Seong-Jin Kim（Korea）
Gou-Young Koh（Korea）
Daizo Koinuma（Japan）
Mizuko Mamura（Japan）
Hiroyuki Mano（Japan）
Hozumi Motohash（i Japan）
Aristidis Moustakas（Sweden）
Masafumi Muratan（i Japan）
Hiroaki Suga（Japan）
i Japan）
Hiroyuki Suzuk（Nobuyuki Takakura（Japan）
Tetsuro Watabe（Japan）
Seiji Yano（Japan）

Time Table
8910111213

14

8:15 Registration（International Congress Center EPOCHAL TSUKUBA）
Poster mounting

Monday, January 12Opening Remarks
8:50 - 8:55
Mitsuyasu Kato (University of Tsukuba, Japan)

Session 1. Short talks（selected from poster abstracts） Chair: Shinae Kondoh (Tokyo Institute of Technology, Japan)
9:00 - 9:20
Yutaro Tsubakihara (Ehime University, Japan)
Arkadia induces ubiquitylation and degradation of Smad6
9:20 - 9:40
Kyung-Min Yang (CHA University, Korea)
Cytoplasmic DRAK1 overexpressed in HNSCC cells inhibits TGF-β1 tumor suppressor activity
9:40 - 10:00
Takahiro Kuchimaru (Tokyo Institute of Technology, Japan)
Non-invasive imaging of activation of HIF and TGF-β/Smad signaling in breast cancer progression
10:00 - 10:20
Ai Takemoto (Cancer Chemotherapy Center, JFCR, Japan)
Aggrus-induced platelet aggregation promotes tumor metastasis by enhancing EMT
10:20 - 10:40
Masamitsu Konno (Osaka University, Japan)
Embryonic MicroRNA-369 regulates pyruvate kinase splicing form by stabilizing translation of splicing
10:40 - 11:40
Poster Viewing 1 / Coffee Break
11:40 - 13:00

LunchSession 2. TGF-β signaling
Chair: Keiji Miyazawa（University of Yamanashi, Japan）
13:00 - 13:30
Carl-Henrik Heldin（Uppsala University, Sweden）
Mechanism of TGFβ-induced epithelial-mesenchymal transition
13:30 - 14:00
Aristidis Moustakas（Uppsala University, Sweden）
Regulation of BMP signaling during cell differentiation in human cancer
14:00 - 14:30
Mitsuyasu Kato（University of Tsukuba, Japan）
Roles of MafK and Gpnmb in malignant progression of breast cancer

Special Lecture 1
Chair: Carl-Henrik Heldin（Uppsala University, Sweden）
14:30 - 15:10
Seong-Jin Kim（CHA University of Medicine and Science, Korea）
Effects of Smad3 linker and C-tail phosphorylation on tumorigenesis and metastasis

15 15:10 - 16:10

Poster Viewing 2 / Coffee Break16

17Session 3. Cancer and metabolism-1
Chair: Takeshi Imamura（Ehime University, Japan）
16:10 - 16:40
Eiji Hara（Japanese Foundation for Cancer Research, Japan)）
Cellular senescence and cancer: a gut microbial connection
16:40-17:10
Hiroyuki Suzuki（University of Tsukuba, Japan）
Roles of THG-1/Tsc22D4 in squamous cell carcinoma development
Special Lecture 2
Chair: Mitsuyasu Kato（University of Tsukuba, Japan）
17:10 - 17:50
Hiroaki Suga（The University of Tokyo, Japan）
Non-traditional drug discovery using artificial macrocycles for cancer therapeutics
Special Remarks 17:50 ‒ 18:00 Kohei Miyazono (The University of Tokyo, Japan)
18:00 - 18:10

18 18:20 - 20:30
1920

Group PhotoBanquet（International Congress Center EPOCHAL TSUKUBA）
Greetings from the President of University of Tsukuba : Kyosuke Nagata (University of Tsukuba, Japan)
Poster Award

Joint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor Microenvironment

Tuesday, January 13
8910

8:30 Registration（International Congress Center EPOCHAL TSUKUBA）
Chair: Takeshi Imamura（Ehime University, Japan）
Session 3. Cancer and metabolism-2
08:40 - 09:10
Hozumi Motohashi（Tohoku University, Japan）
Functional Nexus between Keap1-Nrf2 System and Cellular Metabolism
Session 4. Hematology and Immunology
Chair: Susumu Itoh (Showa Pharmaceutical University, Japan)
9:10 - 9:40
Shigeru Chiba（University of Tsukuba, Japan）
Clonal origin of microenvironmental cells in malignant lymphoma
9:40 - 10:10
Beate Heissig（The University of Tokyo, Japan）
The fibrinolytic system modulates the cytokine and cellular environment during cancer progression and chronicinflammation
10:10 - 10:40
Mizuko Mamura（Tokyo Medical University, Japan, Kyungpook National University, Korea）
Dynamic Smad signaling networks in immune cell regulation
10:40 - 11:00
Coffee Break

1112131415

Session 5. Genome-wide approach
Chair: Hiroyuki Aburatani (The University of Tokyo, Japan)
11:00 - 11:30
Hiroyuki Aburatani（The University of Tokyo, Japan）
Coordinated chromatin regulation by developmental signals during cardiomyocyte differentiation
11:30 -12:00
Daizo Koinuma（The University of Tokyo, Japan）
Identification of Smad regulatory factors through integrated analysis of ChIP-seq data
12:00 - 12:30
Masafumi Muratani（University of Tsukuba, Japan）
Ectopic induction of developmental gene regulatory network by cryptic promoters in gastric cancer
12:30 - 13:30

Lunch

Session 6. Angiogenesis
Chair: Yasufumi Sato（Tohoku University, Japan)
13:30 - 14:00
Marie-José Goumans（Leiden University, the Netherlands）
Impaired macrophage polarization in endoglin haplo-insufficiency leading to defective tissue repair
14:00 - 14:30
Tetsuro Watabe（Tokyo University of Pharmacy and Life Sciences, Japan）
Roles of signal networks during the formation and maintenance of tumor vasculature
14:30 - 15:00
Nobuyuki Takakura（Osaka University, Japan）
Maintenance of the stemness in cancer stem cells requires CD44 expressed by tumor stromal cells via tissue hypoxia
Special Lecture 3
15:00 - 15:40
Gou-Young Koh（KAIST, Korea）
Targeting tumor vasculatures
15:40 - 16:00
Coffee Break / Poster unmounting

16

Chair: Kohei Miyazono（The University of Tokyo, Japan）

Chair: Naoya Fujita（Japanese Foundation for Cancer Research, Japan）
Session 7. Cancer therapy
16:00 – 16:30
Seiji Yano（Kanazawa University, Japan）
Bone microenvironment confers Hsp90 inhibitor resistance in the metastatic small cell lung cancer
16:30 - 17:00
Hiroyuki Mano（The University of Tokyo, Japan）
Targeting essential growth drivers in human cancer
17:00 – 17:30
Yoshihiro Kawasaki, Tetsu Akiyama（The University of Tokyo, Japan)
MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression

17 Closing Remarks

17:30 - 17:40
Carl-Henrik Heldin (Uppsala University, Sweden）

Program
Monday, January 12
08:15–

Registration (International Congress Center EPOCHAL TSUKUBA)
Poster mounting

Opening Remarks
08:50 – 08:55

Mitsuyasu Kato (University of Tsukuba, Japan)

Session 1. Short talks (selected from poster abstracts)
Chair: Shinae Kondoh (Tokyo Institute of Technology, Japan)
09:00 – 09:20
09:20 – 09:40

09:40 – 10:00

10:00 – 10:20

10:20 – 10:40

Yutaro Tsubakihara (Ehime University, Japan)(poster no.26) Arkadia induces ubiquitylation and degradation of Smad6
Kyung-Min Yang (CHA University, Korea)(poster no.01) Cytoplasmic DRAK1 overexpressed in HNSCC cells inhibits
TGF-β1 tumor suppressor activity
Takahiro Kuchimaru (Tokyo Institute of Technology, Japan)(poster no.03) Non-invasive imaging of activation of HIF and TGF-β/Smadsignaling in breast cancer progression
Ai Takemoto (Cancer Chemotherapy Center, JFCR, Japan)(poster no.37) Aggrus-induced platelet aggregation promotes tumor
metastasis by enhancing EMT
Masamitsu Konno (Osaka University, Japan)(poster no.60) Embryonic MicroRNA-369 regulates pyruvate kinase splicing
form by stabilizing translation of splicing

10:40 – 11:40

Poster Viewing 1 (odd number) / Coffee Break

11:40 – 13:00

LunchSession 2. TGF–β signaling
Chair: Keiji Miyazawa (University of Yamanashi, Japan)
13:00 – 13:30
13:30 – 14:00
14:00 – 14:30

Carl–Henrik Heldin (Uppsala University, Sweden)
Mechanism of TGFβ-induced epithelial-mesenchymal transition
Aristidis Moustakas (Uppsala University, Sweden)
Regulation of BMP signaling during cell differentiation in human cancer
Mitsuyasu Kato (University of Tsukuba, Japan)
Roles of MafK and Gpnmb in malignant progression of breast cancer

Joint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor Microenvironment

ProgramSpecial Lecture 1
Chair: Carl–Henrik Heldin (Uppsala University, Sweden)
14:30 – 15:10

Seong–Jin Kim (CHA University of Medicine and Science, Korea)
Effects of Smad3 linker and C-tail phosphorylation on tumorigenesis andmetastasis

15:10 – 16:10Poster Viewing 2 (even number) / Coffee BreakSession 3. Cancer and metabolism-1
Chair: Takeshi Imamura (Ehime University, Japan)
16:10 – 16:40
16:40 – 17:10

Eiji Hara (Japanese Foundation for Cancer Research, Japan)
Cellular senescence and cancer: a gut microbial connection
Hiroyuki Suzuki (University of Tsukuba, Japan)
Roles of THG-1/Tsc22D4 in squamous cell carcinoma development

Special Lecture 2
Chair: Mitsuyasu Kato (University of Tsukuba, Japan)
17:10 – 17:50

Hiroaki Suga (The University of Tokyo, Japan)
Non-traditional drug discovery using artificial macrocycles for cancer
therapeuticsSpecial Remarks
17:50– 18:00

Kohei Miyazono (The University of Tokyo, Japan)

18:00 – 18:10

Group Photo

18:20 – 20:30

Banquet (International Congress Center EPOCHAL TSUKUBA)

Greetings from the President of University of Tsukuba: Kyosuke Nagata

Poster Award

Program
Tuesday, January 13
08:30 –Registration (International Congress Center EPOCHAL TSUKUBA)

Session 3. Cancer and metabolism-2
Chair: Takeshi Imamura (Ehime University, Japan)
08:40 – 09:10

Hozumi Motohashi (Tohoku University, Japan)
Functional Nexus between Keap1-Nrf2 System and Cellular Metabolism

Session 4. Hematology and Immunology
Chair: Susumu Itoh (Showa Pharmaceutical University, Japan)
09:10 – 09:40
09:40 – 10:10

10:10 – 10:40

10:40 – 11:00

Shigeru Chiba (University of Tsukuba, Japan)
Clonal origin of microenvironmental cells in malignant lymphoma
Beate Heissig (The University of Tokyo, Japan)
The fibrinolytic system modulates the cytokine and cellular environment
during cancer progression and chronic inflammation
Mizuko Mamura (Tokyo Medical University, Japan, Kyungpook National University, Korea)
Dynamic Smad signaling networks in immune cell regulation

Coffee BreakSession 5. Genome-wide approach
Chair: Hiroyuki Aburatani (The University of Tokyo, Japan)
11:00 – 11:30

11:30 – 12:00

12:00 – 12:30

12:30 – 13:30

Hiroyuki Aburatani (The University of Tokyo, Japan)
Coordinated chromatin regulation by developmental signals during
cardiomyocyte differentiation
Daizo Koinuma (The University of Tokyo, Japan)
Identification of Smad regulatory factors through integrated analysis ofChIP-seq data
Masafumi Muratani (University of Tsukuba, Japan)
Ectopic induction of developmental gene regulatory network by cryptic
promoters in gastric cancer

LunchJoint International Symposium on

TGF-β Family and Cancer

Signal Network in Tumor MicroenvironmentProgram
Session 6. Angiogenesis
Chair: Yasufumi Sato (Tohoku University, Japan)
13:30 – 14:00

14:00 – 14:30

14:30 – 15:00

Marie–José Goumans (Leiden University, the Netherlands)
Impaired macrophage polarization in endoglin haplo-insufficiency
leading to defective tissue repair
Tetsuro Watabe (Tokyo University of Pharmacy and Life Sciences, Japan)
Roles of signal networks during the formation and maintenance of tumor
vasculature
Nobuyuki Takakura (Osaka University, Japan)
Maintenance of the stemness in cancer stem cells requires CD44 expressedby tumor stromal cells via tissue hypoxia

Special Lecture 3
Chair: Kohei Miyazono (The University of Tokyo, Japan)
15:00 – 15:40

Gou–Young Koh (KAIST, Korea)
Targeting tumor vasculatures

15:40 – 16:00

Coffee Break
Poster unmounting

Session 7. Cancer therapy
Chair: Naoya Fujita (Japanese Foundation for Cancer Research, Japan)
16:00 – 16:30

16:30 – 17:00
17:00 – 17:30

Seiji Yano (Kanazawa University, Japan)
Bone microenvironment confers Hsp90 inhibitor resistance in themetastatic small cell lung cancer
Hiroyuki Mano (The University of Tokyo, Japan)
Targeting essential growth drivers in human cancer
Yoshihiro Kawasaki, Tetsu Akiyama (The University of Tokyo, Japan)
MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6
induction to promote cell cycle progression

Closing Remarks
17:30 – 17:40

Carl-Henrik Heldin (Uppsala University, Sweden)