III. RESEARCH DIVISIONS AND
LABORATORIESIII. RESEARCH DIVISIONS AND LABORATORIES (2013.6.1)
III-1. DEPARTMENT OF NUCLEAR SCIENCEAND ENGINEERING
By the reorganization of the Institute in 2003, thisdepartment, which consists of Division of Nuclear
Engineering Science and Research Center for Safe
Nuclear System, was formed. This department covers awide research field such as the reactor safety, themanagement of radioactive materials, the development
and effective use of nuclear energy, the studies on therecycling of nuclear fuels, and research reactor
utilization.

III-1-1．Division of Nuclear Engineering Science
Professors
TAKAHASHI, Sentaro, Ph. D. (Hokkaido Univ.),
Radiation Health Sciences
YAMANA, Hajimu, D. Eng. (Tohoku Univ.),
Radiochemistry
MORI, Yoshiharu, D. Eng. (Kyushu Univ.),
Accelerator Physics
NAKAJIMA, Ken, D. Eng. (Hokkaido Univ.),
Nuclear Engineering
UNESAKI, Hironobu, D. Energy Sc. (Kyoto Univ.),
Reactor Physics and Engineering
MORIYAMA, Hirotake, D. Eng. (Kyoto Univ.),
Nuclear Material
MISAWA, Tsuyoshi, D. Eng. (Kyoto Univ.),
Reactor Physics and Engineering
SAITO, Yasushi, D. Eng. (Kyoto Univ.),
Thermal and Fluid Engineering
OHTSUKI, Tsutomu, D. Sc. (Tokyo Metropolitan
Univ.), Nuclear Chemistry
Associate Professors
FUJIKAWA, Yoko, D. Eng. (Kyoto Univ.),
Environmental Science
OKI, Yuichi, D. Sc. (Univ. of Tsukuba),
Nuclear Chemistry, Health Physics
XU, Qiu, D. Eng. (Kyushu Univ.),
Radiation Damage in Metals
FUJII, Toshiyuki, D. Eng. (Osaka Univ.),
Physical Chemistry
TAKAMIYA, Koichi, D. Sc. (Osaka Univ.),
Nuclear Chemistry
TAKAHASHI, Tomoyuki, D. Eng. (Kyoto Univ.),
Environmental Health Physics
ISHI, Yoshihiro, Ph.D. (Niigata Univ.),
Accelerator Physics
TAKAHASHI, Toshiharu, D. Sc. (Tohoku Univ.),
Solid State Physics
KINASHI, Yuko, M.D., D. Med. Sc. (Kyoto Univ.),
Radiation Oncology

YAMAMOTO, Toshihiro, D. Eng. (Osaka Univ.),
Reactor Physics
FUKUTANI, Satoshi, D. Eng. (Kyoto Univ.),
Environmental and Sanitary Engineering
PYEON, Cheol Ho, D. Energy Sc. (Kyoto Univ.),
Nuclear Reactor Physics
Assistant Professors
KOIDE, Hiroaki, Nuclear Engineering
IMANAKA, Tetsuji, Nuclear Engineering
KUBOTA, Takumi, D. Eng. (Tohoku Univ.),
Radiochemistry
KAWABE, Hidenori, D. Eng. (Kobe Univ.),
Earthquake Engineering
SHEN, Xiu-Zhong, D. Eng. (Shanghai Jiao-Tong
Univ.), Nuclear Reactor Safety Engineering
HORI, Jun-ichi, D. Eng. (Tokyo Inst. of Tech.),Nuclear Engineering
SATO, Koichi, D. Eng. (Kyoto Univ.),
Radiation Effects in Solids
YASHIMA, Hiroshi, D. Eng. (Tohoku Univ.),
Radiation Control
UEHARA, Akihiro, D. Eng. (Kyoto Inst. of Tech.)Analytical Chemistry
UESUGI, Tomonori, D. Sc. (Univ. of Tokyo),Accelerator Science and Engineering
SEKIMOTO, Shun, D. Eng. (Kyoto Univ.),
Radiochemistry and Geochemistry
SANO, Tadafumi, D. Eng. (Osaka Univ.),
Reactor Physics
KURIYAMA, Yasutoshi, D. Sci. (Osaka Univ.),
Accelerator Physics
TAKAHASHI, Yoshiyuki, D. Eng. (Kyoto Univ.),
Reactor Physics and Engineering
NAKAMURA, Hidehito, Ph.D. (Osaka Univ.),
Radiation Measurements
YAGI, Takahiro, D. Energy Sc. (Kyoto Univ.),
Radiation Detection and Measurement
SHIBAHARA, Yuji, D.Eng. (Osaka Univ.),
Analytical Chemistry
SHIGA, Hiroshi, Radiation Control
IKEGAMI, Maiko, Ph. D. (Kyoto Univ.),
Environmental Engineering
Guest Researcher
Professor
OIGAWA, Hiroyuki, Nuclear Transmutation, Hostlaboratory: Research Reactor Safety
Associate Professor
NISHIHARA, Kenji, Nuclear Transmutation, Hostlaboratory: Research Reactor Safety

This division, which consists of eleven researchlaboratories from the previous research divisions of
Nuclear Safety Research, Nuclear Energy Science andFuel Cycle and Environment, was formed in 2003. Thisdivision covers a wide research field as follows.
III-1-1-(1) Research Reactor Safety
The Kyoto University Research Reactor (KUR) is alight water moderated, tank-type nuclear reactor, toutilize for general nuclear researches cooperated by all
Japanese university researchers. It is used as a strong
neutron source, which is applicable for a broad range of
research fields. Besides the KUR, a 46 MeV electronlinear accelerator (LINAC) is also used as a neutron
source. Also, a new type of Fixed Field Alternating
Gradient (FFAG) proton accelerator is under construction
for the study of accelerator driven sub-critical nuclear
reactor.
Using these three facilities, we are conducting thefollowing research works:i) Experimental Research on Advanced Utilization of
Neutron Sources, Neutron Behavior and Nuclear
Reactions
The experimental researches on nuclear reaction
data (cross sections) are conducted for theutilization of various neutron sources, such as
research reactors, accelerators, and nuclear fusion
reactors. The cross sections of minor actinides
and long-lived fission products are being
measured.
ii) Research and development of future accelerators
based on FFAG principle and their applications
The accelerator based on FFAG principle has aunique feature to utilize non-linear electric andmagnetic fields efficiently, which is quite different
from the ordinary accelerators. Non-linear beam
dynamics, thus, is one of the most interesting
subject in this type of accelerator. Various noble
accelerator technologies based on FFAG principle
such as ionization beam cooling, which could be
useful for intense neutron source, are also underdevelopment.
iii) Integral Tests for Nuclear Data Evaluation andValidation
The evaluation and validation of cross sections
through the analysis of integral experiments such as
critical experiments (Integral Tests) are conducted.
iv) Research on safety of nuclear facilities
Researches on dynamic analysis and seismic safety
evaluation of nuclear facilities are conducted.
Prediction of strong ground motion for large
earthquake is being conducted as well as thedevelopment of analysis methods.

III-1-1- (2) Nuclear Material Control
The activities of this laboratory are focused on
optimum control and use of nuclear materials anddevelopment of innovative nuclear energy system tosolve future energy issues. The current research subjects
include:i) Study on innovative nuclear energy system withhigh potential on non-proliferation and nuclear
materials saving.
ii) Study on energy policy issues, with special
emphasis on the role of nuclear energy.
iii) Study on nuclear security methodology including
safeguards, physical protection, proliferation
resistance evaluation and nuclear material detection
technology.
This laboratory is related to the Department of
Socio-Environmental Energy Science (Energy Policy),
Graduate School of Energy Science, Kyoto University.
The studies conducted in this laboratory are made bymerging both the technical and sociological aspects ofnuclear energy, which is inevitable for discussing the roleof nuclear materials as energy resource today and in the
future.
III-1-1- (3) Radioactive Waste Management
The research activities of this laboratory are focusedon radioactive waste management experimentally andtheoretically. Studies on nuclear safety are also important
themes. The current subjects are as follows:i) Fundamental research on treatment and disposal ofradioactive wasteii) Technical aspects of radioactive waste treatment
facilitiesiii) Decommissioning of nuclear facilitiesiv) Distribution and migration of radionuclides in the
groundv) Measurement of environmental radioactivityvi) Radiation
protection
fromenvironmental
radioactive pollution
III-1-1- (4) Radiation Safety and Control
The laboratory of Radiation Safety and Control
engages in accumulating the fundamental and scientificknowledge with relation to the safe and reliable control ofradiation use in the nuclear industries and several
radiation facilities. At present, following subjects arecarried out with collaboration of multi-disciplinary
researchers, including engineering, technology, biology,
medicine and environmental science:i) Radiation safety in and surrounding the nuclear
plants, in order to develop an advanced
radiation safety management system andcontrol procedures, with using experienceswith KUR and KUCA.

ii) The level and movement of radioactive gas andaerosols generated by the accelerators, fromthe view point of radiation safety assessment.
iii) Behavior and kinetic of radio-nuclides
originating from nuclear waste in soil andplants, especially the modeling of transfer ofradio-carbon and radio-cesium.
iv) Measurement and control of radioactivity
induced by neutron and charged particles innuclear plants and accelerators.
v) Health effects and risks of radiation andradioactive materials, with relation to the
nuclear industries and boron neutron capture
therapy.
III-1-1- (5) Isotope Production and Application
This laboratory is focusing on studies concerning the
production of isotopes using KUR and their various
applications. The current research subjects are as
follows:i) Multitracer preparation and its applicationii) Trace element analysis by neutron activation
methodiii) Study on nuclear decay of actinide elementsiv) Study on neutron energy spectrum induced by
the Hiroshima atomic bomb using fast neutron
product of 63Ni
v) Environmental science study using long-lived
nuclidesvi) Production mechanism of radioactive aerosol
and its characteristics
III-1-1- (6) Nuclear System
To realize an emergent nuclear system with enhanced
safety and high efficiency, this laboratory is performing
basic studies on the nuclear characteristics of nuclear
systems, which are subject to neutron transport andnuclear reactions, mainly based on reactor physics
experiments using the Kyoto University Critical
Assembly (KUCA). The current research subjects ofthis laboratory are as follows:i) Development of accelerator driven system (ADS).
ii) Nuclear characteristics of next generation reactors
including (a) thorium fueled reactors, (b) reactors
for incinerating long-lived radioactive elements,(c) high performance research reactors, and so on.
iii) Research on reactor physics experimental
technique based on reactor noise analysis or higher
mode analysis.
iv) Development of neutron detectors and innovative
experimental techniques for various reactor
physics experiments and for hidden illicit material
detection system by radiation detecting techniques.

III-1-1- (7) Heat Transport
Research activity of this laboratory covers (a)thermal-hydraulics of nuclear energy, (b) fundamental
aspects of multiphase flows, (c) boiling heat transfer, and(d) flow visualization and measurement using neutron
radiography. Current research subjects include:i) Application of wire-mesh sensors and multi-sensor
probes to measurement of characteristics ofgas-liquid two-phase flow.
ii) Thermal-hydraulic characteristics of liquid-metal
two-phase flow by using potential probes.
iii) Heat transfer enhancement due to radiationinduced surface activation (RISA) by using
gamma-ray and proton beam.
iv) Application of neutron radiography to flow
visualization and measurement.
v) Direct contact phase change of water droplets in a
molten metal pool.
III-1-1- (8) Materials Radiation Effects
The purpose of this research laboratory is tounderstand the fundamental aspects of irradiation effects
in solids by high energy particles. It crosslinks with
nuclear energy technology as well as solid state physics.
The current research subjects are as follows:i) Irradiation damage in metals, ceramics andsemiconductors from low to high temperatures.
ii) Development of materials for advanced nuclear
energy system.
iii) Computer simulation of irradiation effects insolids.
iv) Safety assessment of materials for nuclear power
plants.
v) Development of materials for accelerator-driven
subcritical reactors
III-1-1- (9) Environmental Radionuclide Science &Engineering
Current studies in this laboratory have been
focusing on transport, redistribution and remediationof trace elements and radionuclides released in theenvironment through anthropogenic activities andnatural phenomena. We have developed thetechnologies for on-site remediation of water bodies
contaminated with refractory organic compounds,
toxic trace elements and/or radionuclides. The
mechanisms of the removal of contaminants areinvestigated using X-ray absorption spectroscopy.
Analytical methodologies for on-site analyses of traceelements are also developed using highly sensitive
portable voltammetry instrument.
The ongoing research topics are as follows:i) The adsorption of radionuclides with bentonite,
zeolite, and activated carbon was investigated.
Of the radionuclide tracers used,
Cs-134,Sr-85, and I-131 were produced at the KUR.
Cs-134 and Sr-85 was removed with bentonite
and zeolite. I-131 was hardly removed withbentonite, zeolite, and activated carbon.

ii) Soil contaminated with heavy metals was treatedusing a solution of natural organic matter extracted
from plant wastes. The decontaminating ability ofthe extract was equivalent to 10-3 M EDTA.
iii) The remediation of farm effluents and river watercontaminated with humic substances, recalcitrant
organic compounds and estrogens was investigatedby using soil filtration technique. After thelaboratory experiments and pilot study, an actual
treatment system were built and started to operate
in Japan.
iv) The biological filtration system for simultaneous
removal of Fe, As, Mn and NH4+ fromgroundwater was developed. After 7 years of pilot
study and a mechanistic study of As(III) removal
mechanisms in the biological filtration using X-ray
absorption fine structure, an actual treatment unit
for potable water was constructed in Vietnam. The
performance of the actual systems is now
monitored.
v) Co-precipitation of radioactive cesium from theextracts of municipal wastes with various
metal-ferrocyanide compounds is investigated.
Experiments are now under way to clarify the
coagulation
precipitation
characteristics,
elemental composition and crystal structure of the
precipitates, and the relevance of suchcharacteristics of the precipitate with the removalof radioactive cesium.
III-1-1- (10) Nuclear Recycle ChemistryThis laboratory investigates the basic chemical
characteristics of lanthanide and actinide in various
liquids, which is essential for developing advanced
chemical processing techniques for the recycle ofradioactive substances. Specially focused technologicaltargets of this chemical research are reprocessing of spent
nuclear fuels, partitioning and transmutation, andradioactive waste management.
Current research subjects are:i) Coordination
properties
andseparation
characteristics of f-elements in high temperaturemelts and highly concentrated electrolyte solutionsii) Chemistry for the advancement of the processingof nuclear fuels and radioactive wastesiii) Mass-independent isotope effects in chemical
exchange reactionsiv) Radiochemical and analytical chemistry ofelements related to nuclear fuel cycle.
III-1-1- (11) Quantum Beam System (Visiting ResearchLaboratory)
In order to promote research systematically andsynthetically by inviting active researchers who cover
the field of quantum beam source development or
nuclear safety, this laboratory has been prepared.

III-1-2. Research Center for Safe Nuclear System
Director
KAMAE, Katsuhiro, D. Eng. (Nagoya Inst. of Tech.),Earthquake Engineering
Professors
MORI, Yoshiharu, D. Eng. (Kyusyu Univ.),(Concurrently) Accelerator Physics
Associate Professor
ISHI, Yoshihiro, PhD (Niigata Univ.),(Concurrently) Accelerator Physics
UEBAYASHI, Hirotoshi, D. Eng. (Osaka Inst. of
Tech.), Earthquake Engineering
Assistant Professors
KAWABE, Hidenori, D. Eng. (Kobe Univ.),(Concurrently) Earthquake Engineering
UESUGI, Tomonori, D. Sci. (Univ. of Tokyo),(Concurrently) Accelerator Physics
KURIYAMA, Yasutoshi, D. Sci. (Osaka Univ.),(Concurrently) Accelerator Physics
The Research Center for Nuclear Safety System wasestablished originally to promote social understanding ofsafety of nuclear facilities and research activities at the
Research Reactor Institute.
It has two researchlaboratories which are Nuclear Disaster Prevention
System and Hybrid Nuclear System.
III-1-2-(1) Nuclear Disaster Prevention System
Social consensus regarding energy problems isessential to the sustaining development of humankind. In
this laboratory, the strategy of disaster prevention inelectricity sources is studied to construct safe and stableenergy system focusing upon human disaster as well as
natural disaster, especially by earthquake.
The current main research subjects are as follows:i) Study on the formation of public consensus on
matters of energy in society.
ii) Study on the systematization of disaster prevention
system focusing upon human disaster as well as
natural disaster, especially by earthquake.
iii) Study on the strong ground motion prediction to
mitigate earthquake disaster.
iv) Study on the strategy of earthquake disaster
reduction in collaboration with local government.
III-1-2-(2) Hybrid Nuclear System
Novelnuclearpower
systemsuch
as
ADS(Accelerator Driven System), intense neutron
source and their applications using FFAG accelerators
are studied.
The FFAG(Fixed Field Alternating
Gradient) accelerator has a unique feature comparedwith accelerators, which can utilize nonlinear beam
optics effectively to realize a zero chromaticity inbeam behavior providing the large dynamic apertures,and is conceived as one of the most suitableaccelerators for intense hadron and muon
accelerations and also for an intense secondary
particle source using ERIT (Emittance Recovery
Internal Target) with ionization cooling.

III-2. DEPARTMENT OF MATERIAL SCIENCE
In the department our attention is focused on materialscience with devices and facilities developed uniquelyand on the creation of highly-qualified quantum beams
such as neutrons, nuclei and high-energy photons.

III-2-1. Division of Quantum Beam Material Science
Professors
FUKUNAGA, Toshiharu, D. Eng. (Tohoku Univ.),
Neutron Scattering
KAWABATA, Yuji, D. Eng. (Kyoto Univ.),
Neutron Physics and Engineering
OHKUBO, Yoshitaka, Ph. D. (Purdue Univ.),
Applied Nuclear Physics
MORIMOTO, Yukio, D. Sc. (Osaka Univ.),
Protein Crystallography
SETO, Makoto, D. Sc. (Kyoto Univ.),
Solid State Physics
SUGIYAMA, Masaaki, D.Sc.(Kyoto Univ.),
Radiation Physics
Associate Professors
TANIGUCHI, Akihiro, D. Eng. (Nagoya Univ.),
Nuclear Physics
HINO, Masahiro, D. Sc. (Kyushu Univ.),
Neutron Optics
CHATAKE, Toshiyuki, D. Sc. (Tokyo Inst. of Tech.),Neutron Structural Biology
KITAO, Shinji, D. Sc. (Kyoto Univ.),
Solid State Physics
MORI, Kazuhiro, D. Sc. (Grad. Univ. Advanced
Studies), Materials Structure Science
Assistant Professors
KAWAGUCHI, Akio, D. Sc. (Kyoto Univ.),
Polymer Physics
KOBAYASHI, Yasuhiro, D. Eng. (Osaka Univ.),
Solid State Physics
SATO, Nobuhiro, D. Eng. (Kyoto Univ.),
Polymer Chemistry
TANIGAKI, Minoru, D. Sc. (Osaka Univ.), Nuclear
Physics
KITA, Akiko, D. Sc. (Tokyo Inst. of Tech.),Structural Biology
ITO, Daisuke, D. Eng. (Tokyo Inst. of Tech.),Thermal Hydraulics
OBA, Yojiro, D. Eng. (Keio Univ.), Magnetic andMetallic Materials Science
ONODERA, Yohei, D. Eng. (Kyoto Univ.),

Material Structure Science
This Division has six laboratories collaborating eachother.
In this division, the research projects arepromoted especially on material science with particle
beams of neutron, RI, electron and -ray.
In theprojects, the division also directs its effort to creating andcharacterizing highly qualified particle beams and todevelopment of new facilities and devices for theadvanced uses of them.
The current research projects
in the laboratories are described below.

III-2-1- (1) Neutron Scattering Science
Neutron, the best partner of the X-ray, scattering anddiffraction method are the most powerful technique toinvestigate and clarify the relationship between structureand function of widely distributed materials. Ourlaboratory concentrates on quantum beam studies of:i) Structural biology of the macromolecule from theterm of proton or protonation in a biologicalpathway. It is a very popular mechanism as acatalytic material. Three-dimensional structures at
the atomic resolution and quaternary structures ofproteins will deeply give us an information forunderstanding the physiological biophysics by useof the neutron and synchrotron radiation sources.
ii) The structure of various kinds of amorphousmaterials and protein complexes or aggregates by
the method of X-ray or neutron scattering in orderto clarify the quaternary structure and highly
expressing functions.
Also we have actively collaborated with other high-flux
facilities: JRR-3M, J-PARC and synchrotron radiation
facilities PF and SPring-8
III-2-1- (2) Neutron Material Science
In this laboratory, static and dynamical structures ofdisordered (amorphous, glass and gel), non-equilibirum
and crystalline materials are investigated bycomplementary use of neutron and x-ray scatterings. The
obtained results are returned for production of intelligent
and functional materials. Therefore, several subjects inthe laboratory are focused to get structural information offunctional and energy materials.
III-2-1- (3) Neutron Optics
The main research filed of this laboratory is thedevelopment of neutron optical devices and its utilization.
The current subjects are as follows:i) Development of VIN-ROSE which is a set ofneutron resonance spin echo（NRSE） and MIEZE
spectrometers for a pulse neutron source.
ii) Development of neutron optical devices including
multilayer mirrors, supermirrors, monochromators,
polarizers, analysers, and spin control devices,such as various type of spin flippers.
iii) Utilization of thermal neutron imaging forengineering, agriculture, archeology and so on.
After the successful development of MIEZE and
NRSE in C3-1-2(JRR-3), BL-10 and BL-05(J-PARC), theconstruction of the beam line of VIN-ROSE has started in
BL-06, J-PARC.
III-2-1- (4) Nuclear Beam Material Science
This laboratory is mainly concerned with thedevelopment of production methods of radioactive
nuclear beams and their applications. The current
research subjects are as follows:i) Development of on-line isotope separation system
for fission products.
ii) Nuclear structure studies of neutron-rich nuclei
around mass number A = 150.
iii) Research and development of nuclear radiation
techniques.
iv) Condensed matter physics and chemistry using thetime-differential
perturbed-angular-correlation
technique.
III-2-1- (5) Nuclear Radiation Physics
Research subjects of this laboratory are focused on
the followings:i) Condensed matter physics with nuclear methods,
such as the study on the electronic states ofsynthetic metals and superconductors using
Mössbauer spectroscopy.
ii) Fundamental studies of nuclear resonant excitation
using synchrotron radiation and its application formaterials and biological sciences.
iii) Fundamental studies of X-ray radiation withcharged particle beams.
III-2-1- (6) Radiation Material Science

It is well known that a material structure and its
dynamical character are deeply related. In the case of afunctional material with a nano-scale structure, it isessential to reveal a mechanism of function tounderstand its dynamical character based on the
structure. Along this line, this research group studies
the nano-scale static and dynamical structures offunctional materials such as supercritical fluid,polymer aggregates, gel and protein, with neutron,
X-ray scattering methods.
The current research topics are as follows:i) Structure and Dynamics of protein complex with
Neutron and X-ray scattering methodsii) Size distribution of nano precipitates in metal alloy
with SANS and SAXS.
iii) Development of analyzing method for SANS andSAXS.
iv) Application of -ray-induced reaction fordeveloping nanomaterials, such as chemical
modification of nanoparticles and simultaneouscross-linking and decomposing of multi-component
polymer systems.
v) Exploration of the environmentally-friendly
material synthesis process with -ray irradiation bytaking advantage of their reaction free fromchemical initiators or catalysts.

III-3. DEPARTMENT OF RADIATION LIFE SCIENCE
AND RADIATION MEDICALSCIENCEThis department consists of one division and one
center, that is, division of radiation life science andparticle radiation oncology research center. In particle
radiation oncology research center, advanced neutron
therapy session, which is financially maintained byprivate donations, was established since 2008.

Five research groups are collaborating for the researchon physics, biology, chemistry and medicine using
photon radiations and neutrons.

III-3-1. Division of Radiation Life Science
Professors
FUJII, Noriko, D. Med. Sc. (Tokyo Med. Den. Univ.),
Biochemistry, Protein Chemistry
MASUNAGA, Shin-ichiro, D. Med. Sc. (Kyoto Univ.)
Radiation Oncology
Associate Professors
KOBAYASHI, Tooru, D. Eng. (Tokyo Inst. of Tech.),Medical Physics and Engineering
SAKURAI, Yoshinori, D. Eng., (Kyoto Univ.)
Medical Physics and Engineering
TANO, Keizo, D. Med. Sc. (Nara Medical Univ.),
Molecular Biology
Senior Lecturer
KINOUCHI, Tadatoshi, Ph. D. (Univ. of Tokyo),
Biochemistry, Gerontology
Assistant Professors
TANAKA, Hiroki, D. Eng. (Kyushu Univ.),
Medical Physics and Engineering
SAITO, Takeshi, D. Sc. (Hiroshima Univ.), Radiation
Physical Chemistry, Radiation Biology
This division is composed of three laboratories:
Radiation Medical Physics, Radiation Biochemistry andBiological Function, and Radiation Biology.
The current research projects are as follows:
III-3-1- (1) Radiation Medical Physics
Medical physics is the general term for the physics andtechnology which are supporting medicine, especiallyradiation therapy and particle therapy. As it covers manydifferent fields, the important subjects are “promotion for
the advance of radiation therapy” and “quality assurance
for radiation therapy”. Our group is focusing on “boron
neutron capture therapy (BNCT)”, which is one kind ofparticle therapies.We are studying for the advance of
BNCT as follows:i) Advance of the BNCT irradiation fields: We are
studying about the improvement of the irradiation
field at the Heavy Water Neutron Irradiation
Facility of KUR. We are also performing thedesign studies for accelerator-based irradiation
system.
ii) Development of dose estimation methods: We
are developing the separative estimation methods
for four components such as thermal (<0.5 eV),
epi-thermal (0.5 eV to 10 keV) and fast neutrons(>10 keV), and gamma ray. Our final goal is thecompletion of the real-time estimation system for
3D dose distribution under BNCT.
iii) Establishment of quality assurance (QA): We are
studying about the QA program for BNCT, such as
the standard dosimetry for the irradiation field, thedose estimations for pre- and post-treatment, theexposure estimation for patient, etc.

III-3-1- (2) Radiation Biochemistry and Biological
Function
Our study is focused on various post-translational
modifications, such as: deamidation, racemization,
stereoinversion, isomerization, truncation, phosphorylation,oxidation and an increase in intramolecular disulfide
bonding of inert proteins, such as lens, brain and skin.
These post-translational modifications generate during
aging process spontaneously and also are increased byUV (ultraviolet), gamma and neutron irradiation.
Our aim is to elucidate the post-translational
modifications which can induce the partial unfolding of
the protein, resulting in a reduction of the proteinfunctions, followed by the related diseases. The current
research includes the following projects:i) Study of post-translational modifications of lensproteins induced by aging, UV, gamma and neutron
irradiation.
ii) Study of mechanism of D-amino acid formation inprotein. Racemization of Asp residues triggers theaggregation of protein.
iii) The identification of D-beta-Asp containing protein
in UV-irradiated skin from elderly human donors.
iv) Study of the radioresistant mechanisms in theradioresistant bacteria.
v) Study of a specific enzyme that degrades
D-Asp-containing protein.
III-3-1- (3) Particle Radiation Biology
After the life was born on the earth 3,600 million years
ago, the life has not been separated from various
environmental stresses, such as radiation, temperatureand pressure. And the life built cell structure to
distinguish it from the surrounded environment. Recently,
it has been made clear that a cell is using basic
mechanism of biological reaction for replying to various
stresses. Therefore, basic biological reaction may beclarified by discovering stress response mechanism.
Dysfunction of stress response in cell may be a cause ofcarcinogenesis and acceleration of aging. If so, it is also
expected that a disease is cured by fixing a stressresponse function normally.
Along such a working hypothesis, we choose theenvironmental stress factors, such as radiation,
hyperthermia, and pressure, and have been studying on
the following topics.
i) Mechanism of carcinogenesis and aging.
ii) Mechanism of stress response.

In

addition, in order tocontribute to thedevelopment of cancer treatment, we are carrying out
basic research in biology, bioscience and medical
science focusing on BNCT (Boron Neutron Capture
Therapy) that have been conducted at KURRI.
Our current research topics are:i) DNA repair and intracellular mechanism.
ii) Evaluation of cancer treatment by detecting thesusceptibility of solid tumor cells.
iii) Influence on distant metastases by treatment oflocal tumor, screening for new 10B-compounds
for BNCT.
Some researchers in the field of engineering or
chemistry are carrying out the study of biologicalmatter at KURRI, we are working positively tocollaborate them to launch a new project.
III-3-2. Particle Radiation Oncology Research Center
Director
TAKAHASHI, Sentaro, Ph.D. (Kyoto Univ.),
Radiation Health Sciences
Professor
ONO, Koji, M. D., D. Med. Sc. (Kyoto Univ.),
Radiation Oncology
SUZUKI, Minoru, M. D., D. Med. Sc. (Kyoto Univ.),
Radiation Oncology
Assistant Professors
KONDO, Natsuko, M. D., D. Med. Sc. (Nara Medical
Univ.), Neuro-surgery
NARABAYASHI, Masaru, M.D., Radiation Oncology
FUJIMOTO, Nozomi,
Medical Physics and Engineering
III-3-2-(1) Particle Radiation Oncology
The research project of Boron Neutron Capture
Therapy (BNCT) at KURRI was re-started in 1990.
Over 400 times BNCT for malignant tumors, that are
refractory to standard treatment, have been performed by
BNCT researchers of KURRI and their collaborators.
They consist of many cases of malignant brain tumors(mainly malignant glioma), melanoma of the skin, H & N
cancers, and more than 5 cases of lung (including
malignant pleural mesothelioma) and liver cancers,
respectively. The 5-year survival rate of malignant
melanoma of the skin is 55%. The first BPA-BNCT for
malignant glioma in the world and first clinical trial using
epithrermal neutron beam without craniotomy in Asia
were performed in KURRI at the beginning of 1994 and2002, respectively. According to the paper that reported
the effectiveness of Temozolomide (TMZ) on newly
diagnosed glioblastoma (GBM), X-ray therapy with orwithout TMZ achieved MSTs of 12.1 and 14.6 months,
respectively. On the other hand, the median survival time(MST) after BNCT to this tumor is over 24 months. Only
quite small number of patients received TMZ medication.
So, we consider that BNCT is more effective than
TMZ+X-ray therapy. For recurrent GBM, BNCT looks
superior treatment than standard supportive therapy.
From the previous report on TMZ+X-ray therapy trial,
we can estimate MST of 7-8 months for recurrent GBM
cases. BNCT for this disease elongated the MST to 11.8
months. Hazard ratio is around 1.5-1.7. In December of2001, the first patient of recurrent H & N tumor in theworld was treated by BNCT. An analysis was also
performed on all recurrent H & N tumors. BNCT showed
excellent effects on the cases of histological type of
adenocarcioma. All patients of this pathology are
surviving after BNCT. Malignant melanoma is also goodin clinical course after BNCT, however, that of squamouscell carcinoma patients is not good. Although the reason
is not clear, far advanced many cases might be includedin this histological type group. In total, about 25% of thepatients without treatment option except BNCT survived
over 5 years after BNCT. Lung cancer, especiallymalignant pleural mesothelioma, and primary or
secondary liver tumors are other new targets of clinicalstudy. BNCT gave an excellent effect to some of them.
New interesting tumor is Paget disease besides a breast.
Large disease is completely resolved with surgicalresection by BNCT.
Based on these data, the center is developing an
accelerator neutron source in collaboration with twocompanies. The neutron intensity at the exit of collimatorand thermal neutron production at 5 cm depth are 1.8 and2.0 times larger than those of KUR. At present physicaland radiobiological studies of neutrons have been
completed. Using this system, a clinical trial of BNCT
for recurrent malignant brain tumors has been started
since October in 2012. Development of the AB-BNCT
system is an important first step for a future in which
BNCT will be available in the hospital.
Mission of the center is organization and enforcementof clinical study of BNCT for cancers, and the center isnucleus of BNCT and related researches in whole Japan.
The main practical and research subjects are as follows;
1) Clinical trial using AB-BNCT system.
2) Pioneering RB-BNCT for common cancer
3) Research on effect of BNCT for normal organs or
tissues.
III-3-2-(2) Advanced Neutron Therapy
As a result of 10B-thermal neutron reaction, energetic
particles of 4He and 7Li, and gamma rays are emitted.
Energies (ranges, LETs) of each particle, 4He and 7Li, are
1.47MeV (8.9m, 165keV/m) and 0.84MeV, (4.8m,
175keV/m) and 0.04% of those are 1.68MeV (9.8m,
170keV/m) and 1.01MeV (5.3m, 190keV/m)corresponding to the nuclear energy state of 7Li generated
in 10B (n, 4He) 7Li reactions, respectively. All of theseparticles possess most effective potential for giving
damage to cells.
If 10B compound accumulates
selectively at higher concentration in all tumor cells thansurrounding normal cells, we can completely destroy thetumor without damage to the normal tissues by BNCT.
There exist the tumor cells in which 10B compound is low
in concentration. Although the proportion of such cells is
not so large, however, it is inevitable in the advanced

malignant tumor. Another weak point of BNCT is thatcurable depth of tumor is limited to about 7cm byattenuation of epi-thermal neutron in a body. It is theobject of our research program to overcome these
problems of BNCT.
To advance the BNCT of the present situation, we
decided to develop a new system of an accelerator and amoderator, and to achieve the neutron field the mostsuitable for BNCT. An accelerator-moderator system
was installed in a medical research lab as one division of
the innovation research laboratory on Apr. 2009. This
accelerator is able to supply 30MeV proton beam of theconstant intensity of 1mA over 1hour continuously. At
present, characteristics of neutron field of an irradiation
port achieved by this system were examined by means ofphysical (dosimetry of mixed radiation fields of neutronand gamma-ray) and biomedical (radiation effect andradiation safety) methods.

III-4. HEAD OFFICE FOR SAFETY MANAGEMENT
Safety operation of the facilities is the most important
issue. The Head Office for Safety Management wasestablished in 2002 to supervise the safety managementin the Institute, especially in the nuclear and radiation
facilities. At present, three divisions, i.e., Quality Control,
Nuclear Fuel Management, and Safety Control Center are
operated under the supervising of this Head Office.

III-5. HEAD OFFICE OFACADEMIC INFORMATIONThis office supports the institute in information-related
aspects. It has mainly three duties interrelated with eachother.
i) Network operation: The office maintains the network
system and operates servers for e-mail and homepage.
ii) Support of research and education: The library is aconstituent unit of the office. Meeting themultidisciplinary character of the institute, itpossesses a wide variety of research journals,
books, and other documents, especially, related tonuclear science and engineering. Through the
network, electronic journals and databases
subscribed by Kyoto University are also available.
The office transmits lectures given in the instituteto other campuses of Kyoto University and otheruniversities via internet TV-systems.
iii) Public relations: The office introduces to the public
activities of the institute through the homepage, by
issuing brochures and progress reports, and byholding an open lecture meeting and open campus.

III-6. TECHNICAL STAFF OFFICE
The technical staff office takes charge of the technicalworks for the operation of a reactor, maintenance of theexperimental facilities, safety control of radiation andradioactive waste disposal. It consists of four groups andeach group has two subgroups.

Supplies Section :Section Chief :General Manager
KOBORI, Hiroshige(Concurrent) Group Chief
Group Chiefs
MINAMI, Kaoru(Concurrent) Subgroup Chief
TSUCHIYAMA, Tatsuo
YOSHINO, Hirofumi
Subgroup Chiefs
OONO, Kazuomi
ZHANG, JianYAMAMOTO, Hiroshi
OKUMURA, Ryo
KAKIHANA, Eiko
Senior Staff Members
ABE, Naoya
HASEGAWA, Kiyoshi
FUJIHARA, Yasuyuki
TAKESHITA, Tomoyoshi
HIRAI, Yasuhiro
YOSHINAGA, Hisao
FUJIWARA, Keiko
ITAMI, Teppei
Technical Staff Members
IINUMA, Yuto
INO, Yuta
IMOTO, Haruka
OGINO, Shinya
KANAYAMA, Masaya
KURIHARA, Kouta
KOBAYASHI,Norika
SAKAMOTO, Masaaki
TANAKA, Yoshiaki
NAKAMORI, Akira
MARUYAMA, Naoya
MIYAKE, Tomohiro
YAMADA, Tatsuya

III-7. ADMINISTRATION OFFICE
Head:Assistant Head (General)
Assistant Head (Finance)
General Affairs Section
Section Chief :HIKITA, Satoru
NAGATA, Toshiyuki
IWASE, Tomohiro
KAWAHARA, Eiji
SUZUKI, Michiyo
IIJIMA, Yuuichi
YAMAMOTO, Yuka
(nurse)Joint Use Program Section:
Section Chief:
NAKAYAMA, Chiyoko
SUGANO, Takahito
Library Section:
Section Chief:
NAKATSUKA, Hiroto
Accounting Section
Section Chief:
WAKABAYASHI, Junichiro

Building Work Section :Section Chief :ADACHI, Kenji
HAYASHI, Yuusaku
MORITA, Masaya
FUJINAGA, Sumio
FUJIKAWA, Sinichi
HIGASHINO, Keita

Electricity Work Section :Section Chief :MORI, Tetsuya
NAKATANI, Daisuke
TOKUDA, Yuichi
Other Utility Work Session :Section Chief :HAYASHI, Yasuhiko
OKADA, Tomohiro