1999-2004 年業績
2004 年

Miyazaki H, Watabe T, Kitamura T, Miyazono K : BMP signals inhibit proliferation and in vivo
tumor growth of androgen-insensitive prostate carcinoma cells. Oncogene, 23 : 9326-9335,
2004.

Zheng H-Y, Kitamura T, Takasaka T, Chen Q, Yogo Y:

Unambiguous indentification of JC

polyomavirus strains transmitted from parents to children. Arch Virol, 149: 261-273, 2004.

Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K.：

Roles for theMH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily
signaling.

J Biol Chem. Jul 23;279(30):31568-74.2004.

Yogo Y, Sugimoto C, Zheng H-Y, Ikegaya H, Takasaka T, Kitamura T: JC virus genotyping offers
a new paradigm in the study of human populations. Rev Med Virol, 14: 1-13, 2004.

Zheng H-Y, Yasuda Y, Kato S, Kitamura T, Yogo Y: Stability of JC virus coding sequences in acase of progressive multifocal leukoencephalopathy in which the viral control region wasrearranged markedly. Arch Pathol Lab Med, 128: 275-278, 2004.

Takasaka T, Miranda J J, Sugimoto C, Paraguison R, Zheng H-Y, Kitamura T, Yogo Y :Genotypes of JC virus in southeast asia and the pacific : implications for human migrations fromasia to the pacific. Anthropological Science, 112 : 53-59, 2004.

Enomoto Y, Enomoto K, Kitamura T, Kanda T: Keratinocyte-specific POU transcription factor
hSkn-la represses the growth of cervical cancer cell lines. Oncogene, 23 : 5014-5022, 2004.

Inoue Y, Kurimoto S, Kameyama S, Ohta N, Akahane M, Yoshikawa K, Yokoyama I, Minami M,OhtomoK,Kitamura

T:Prolonged

renalparenchymal

retentionof99mTc

mercaptoacetyltriglycine after nephron-sparing surgery. Nucl Med Commun, 25 : 509-513, 2004.

Zheng H-Y, Zhao P, Suganami H, Ohasi Y, Ikegaya H, Kim J-C, Sugimoto C, Takasaka T,Kitamura T, Yogo Y : Regional distribution of two related Northeast Asian genotypes of JC virus,
CY-a and -b: implications for the dispersal of Northeast Asians. Microbes Infect, 6 : 596-603,
2004.

Miranda J J, Takasaka T, Zheng H-Y, Kitamura T, Yogo Y : JC virus genotype profile in themamanwa, a philippine negrito tribe, and implications for its population history. AnthropologicalScience, 112 : 173-178, 2004.

Takeuchi T, Konno-Takahasi N, Kasuya Y, Ogushi T, Nishimatsu H, Kitamura T : Interleukin-2
blocks the antitumour activity caused by depletion ofCD25 ＋ cells in a murine renal

adenocarcinoma model. BJU Int, 94 : 171-176, 2004.

Kato A, Kitamura T, Takasaka T, Tominaga T, Ishikawa A, Zheng H-Y, Yogo Y : Detection of thearchetypal regulatory region of JC virus from the tonsil tissue of patients with tonsillitis andtonsilar hypertrophy. J Neurovirol, 10 : 244- 249, 2004.

Takasaka T, Goya N, Tokumoto T, Tanabe K, Toma H, Ogawa Y, Hokama S, Momose A, Funyu T,Fujioka T, Omori S, Akiyama H, Chen Q, Zheng H-Y, Ohta N, Kitamura T, Yogo Y : Subtypes ofBK virus prevalent in Japan and variation in their transcriptional control region. J Gen Virol, 85 :2821-2827, 2004.

Akaza H, Usami M, Hinotsu S, Ogawa O, Kagawa S, Kitamura T, TsukamotoT, Naito S, Hirao Y, Murai M, Yamanaka H : Characteristics of patients with prostate cancer who
have initially been treated by hormone therapy in japan : J-CaP surveillance. Jpn J Clin
Oncol,34(6) : 329-336, 2004.

Konno-Takahashi N, Takeuchi T, Nishimatsu H, Kamijo T, Tomita K, Schalken JA, Teshima S,Kitamura T: Engineered FGF-2 expression induces glandular epithelial hyperplasia in the murine
prostate dorsal lobe. Eur Urol 46: 126-132, 2004.

2003 年

Kaneko T, Takahashi S, Takeuchi T, Goto T, Kitamura T: Castleman's disease in theretroperitoneal space. J Urol, 169: 265-266, 2003.

Zheng H-Y, Sugimoto C, Hasegawa M, Kobayashi N, Kanayama A, Rodas A, Mejia M,Nakamichi J, Guo J, Kitamura T, Yogo Y: Phylogenetic relationships among JC virus strains inJapanese/Koreans and native Americans speaking Amerind or Na-Dene. J Mol Evol, 56: 18-27,
2003.
Takahashi N, Takeuchi T, Shimizu T, Nishimatsu H, Fukuhara H, Kamijo T, Moriyama N, Tejima S,
Kitamura T,: Engineered IGF-I expression induces glandular enlargement in the murine prostate.
J Endourol, 177: 389-398, 2003.

Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T, Okuyama A: Prominent induction ofcyclin B1 in G2/M renal cancer cells with butyrolactone 1. Int J Urol, 10: 323-331, 2003.

Nakagawa T, Kanai Y, Saito Y, Kitamura T, Kakizoe T, Hirohashi S: Increased DNA
methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. JUrol, 170: 2463-22466, 2003.

Konno-Takahashi N, Takeuchi T, Takayuki S, Nishimatsu H, Fukuhara H, Kamijo T, Moriyama N,Tejima S, Kitamura T : Engineered IGF-I expression induces glandular enlargement in themurine prostate. J Endocrinol, 177 : 389-398, 2003.

Takahashi, T., Y. Tanaka, M. Nieda, T. Azuma, S. Chiba, T. Juji, Y. Shibata, and H. Hirai :Dendritic cell vaccination for patients with chronic myelogenous leukemia. Leuk Res 27:795-802,
2003.

Azuma, T., T. Takahashi, A. Kunisato, T. Kitamura, and H. Hirai : Human CD4+ CD25+ regulatory
T cells suppress NKT cell functions. Cancer Res 63:4516-4520, 2003.

2002 年

Homma Y, Yamaguchi T, Kondo Y, Horie S, Takahashi S, Kitamura T: Significance of nocturia in
the international prostate symptom score for benign prostatic hyperplasia. Int J Urol, 167:
172-176, 2002.
Saruwatari L, Sugimoto C, Kitamura T, Ohno N, Sakai E, Shresta P, Hoa BK, Phi PTP, An HPH,Tuyet NTA, Honjo T, Kobayashi N, Zheng H-Y, Takasaka T, Yogo Y: Asian domains of four major
genotypes of JC virus, Af2, B1-b, CY and SC. Arch Virol, 147: 1-10, 2002.

Matsushima H, Kawabe K, Fujime M, Kitamura T, Homma Y, Kishi H, Kawamura T, Umeda T,Ohishi Y, Murai M, Kawai T, Yoshida H, Fukuda T: Treatment of patients with superficial bladdercancer by intravesical instillation of anticancer drugs plus oral chemotherapy following TUR-Bt :A randomized controlled trial. Oncol Rep, 9: 283-288, 2002.

Kitamura T, Nishimatsu H, Hamamoto T, Tomita K, Takeuchi T, Ohta N: EMP combination
chemotherapy and low-dose monotherapy in advanced prostate cancer. Expert Rev Anticancer
Ther, 2: 59-71, 2002.

Takahashi S, Minowada S, Tomita K, Katumata N, Tanaka T, Kitamura T: Massive adrenocorticaladenoma following long-term treatment of 21-hydroxylase deficiency. J Urol, 167: 1390-1391,
2002.

Sugimoto C, Hasegawa M, Kato A, Zheng H-Y, Ebihara H, Taguchi F, Kitamura T, Yogo Y:
Evolution of human polyomavirus JC : Implications for the population history of humans. J MolEvol, 54: 285-297, 2002.

Ohashi Y, Nakai S, Tsukamoto T, Masumori N, Akaza H, Miyanaga N, Kitamura T, Kawabe K,Kotake T, Kuroda M, Naito S, Koga H, Saito Y, Nomata K, Kitagawa M: Habitual intake of lactic
acid bacteria and risk reduction of bladder cancer. Urol Int, 62: 273-280, 2002.

Hirasawa K, Kitamura T, Oka T, Matsushita H : Bladder tumor producing granulocyte colony
stimulating factor and parathyroid hormone related protein. J Urol, 167: 2130, 2002..

Takahashi S, Yamada Y, Homma Y, Horie S, Hosaka Y, Kitamura T: Power doppler
ultrasonography-directed prostate biopsy in men with elevated serum PSA levels : an evaluationof the clinical utility and limitations. Urology, 60: 248-252, 2002.

Azuma T, Horie S, Tomita K, Takahashi T, Tanaka Y, Kashiwase K, Nieda M, Takeuchi T, Ohta N,Shibata Y, Hirai H, Kitamura T: Dendritic cell immunotherapy for patients with metastatic renal
cell carcinoma : University of Tokyo experience. Int J Urol, 9: 340-346, 2002.

Kaneko T, Kurimoto S, Kume H, Kitamura T, : Accidental resection of bilateral ureteric orfices in apatient with ureterosigmoidostomy. BJU Int, 89: 969-970, 2002.

Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R,Higashihara E, Harris PC, Katsuki M, Horie S: Pioglitazone improves the phenotype andmolecular defects of a targeted PKd1 mutant. Hum Molec Genet, 11: 1731-1742, 2002.

Suzuki M, Zheng H-Y, Takasaka T, Sugimoto C, Kitamura T, Beutler E, Yogo Y: Asian genotypesof JC
2002.

virus inJapanese-Americans suggest familial transmission. J Virol, 76: 10074-10078.

Hamamoto T, Beppu H, Okada Ｈ, Kawabata M, Kitamura T, Miyazono K, Kato K: Compounddisruption of Smad 2 acceleratesmalignant progression of intestinal tumors in Apc knockout

mice. Cancer Res, 62: 5955-5961. 2002.

Sugimoto C, Hasegawa M, Zheng H-Y, Demenev V, Sekino Y, Kojima K, Honjo T, Kida H, Hovi T,Vesikari T, Schalken JA, Tomita K, Mitsunobu Y, Ikegaya H, Kobayashi N, Kitamura T, Yogo Y: JC
virus strains indigenous to northeastern Siberians and Canadian Inuits are unique but
evolutionally related to those distributed throughout Europe and Mediterranean areas. J Mol Evol,
55: 322-335, 2002.

Saruwatari L, Zheng H-Y, Takasaka T, Sugimoto C, Sakai E, Bo B, Aung N N, Kitamura T, Yogo Y,Ohno N: Peopling of Myanmar as demonstrated by genotyping of urinary JC virus DNA.
Anthropological Science, 110: 235-249, 2002.

Fujishiro T, Takahashi S, Enomoto Y, Ugawa Y, Ueno S, Kitamura T: Magnetic stumulation of thesacral roots for the treatment of urinary frequency and urge incontinence: An investigational
study and placebo controlled trial. J Urol 168: 1036-1039, 2002.

Takahashi, T., S. Chiba, M. Nieda, T. Azuma, S. Ishihara, Y. Shibata, T. Juji, and H. Hirai. Cuttingedge:

analysisofhumanValpha24+CD8+NKTcells

activatedbyalpha-galactosylceramide-pulsed monocyte-derived dendritic cells. J Immunol 168:3140-3144.
2002.

2001 年

Kondo Y, Homma Y, Takahashi S, Kitamura T, Kawabe K: Transvaginal ultrasound of urethral
sphincter at the mid urethra in continent and incontinent women. J Urol, 165: 149-152, 2001.

Minowada S, Homma Y, Takeuchi T, Kamijo T, Kitamura T: Long-term of endoscopic biopsy andsubsequent nephroureterectomy for upper urinary tract tumor. Int J Urol, 8: 6-9, 2001.

Fukuhara H, Maruyama T, Nomura S, Oshimura M, Kitamura T, Sekiya T, Murakami Y:Functional evidence for the presence of tumor suppressor gene on chromosome 10p15 inhuman prostate cancers. Oncogene, 20: 314-319, 2001.

Ishiwata S, Takahashi S, Homma Y, Tanaka Y, Kameyama S, Hosaka Y, Kitamura T: Noninvasivedetection and prediction of bladder cancer by fluorescence in situ hybridization analysis ofexfoliated urothelial cells in voided urine. Urology, 57: 811-815, 2001.

Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura
M, Onizuka M, Kitamura T, Sekiya T, Reeves RH, Murakami Y: TSLC1 is tumor-suppressor genein human non-small-celllung cancer. Nature Genetics, 27: 427-430, 2001.

Akiyama H, Kurosu T, Sakashita C, Inoue T, Mori S, Ohashi K, Tanikawa S, Sakamaki H,Onozawa Y, Chen Q, Zheng H-Y, Kitamura T: Adenovirus is a key pathogen in hemorrhagic
cystitis associated with bone marrow transplantation. Clin Infect Dis, 32: 1325-1330, 2001.

Nishimatsu H, Suzuki E, Nagata D, Moriyama N, Satonaka H, Walsh K, Sata M, Kangawa K,Matsuo H, Goto A, Kitamura T, Hirata Y: Adrenomedullin induces endothelium-dependentvasorelaxation via the phosphatidylinositol 3-kinase/akt-dependent pathway in rat aorta. CircRes, 89: 63-70, 2001.

Kamijo T, Sato T, Nagatomi Y, Kitamura T : Induction of apoptosis by cyclooxygenase-2 inhibitors
in prostate cancer cell lines. Int J Urol, 8: 35-39, 2001.

Kanda H, Kubo K, Hamasaki K, Kanda Y, Nakao A, Kitamura T, Fujita T, Yamamoto K, Mimura T:
Influence of various hemodialysis membranes on the plasma (1→3)-β-D-glucan level. Kidney Int,60: 319-323, 2001.

Minowada S, Okano Y, Miyazaki J, Homma Y, Kitamura T : Multidisciplinary treatment ofadvanced testicular tumor with bulky live r metastasis. Urol Int, 67: 178-180. 2001.

Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T: Differences in cell kinetic changes
among renal cancer cell lines treated with interferon-α. Int J Urol, 8: 449-454, 2001.

Guo Z, Zheng S-P, Sugimoto C, Wang Y-L, Zheng H-Y, Takasaka T,JC virus genotypes in Northwestern China :Kitamura T, Guo J, Yogo Y:

Implications for its population history. Anthropol Sci,

3: 203-212, 2001.

Kamijo T, Sato S, Kitamura T : Effect of cernitin pollen-extract on experimental nonbacterial
prostatitis in rats. Prostate, 49: 122-131, 2001.

Fujimura T, Takahashi S, Urano T, Ogawa S, Ouchi Y, Kitamura T, Muramatsu M, Inoue S:Differential expression of estrogen receptor β (ER β) and its c-terminal truncated splice variant
ERβcx as prognostic predictors in human prostatic cancer. Biochem Bioph Res Co, 289: 692-699,2001.

Nishimatsu H, Hirata Y, Hayakawa H, Nagata D, Satonaka H, Suzuki E, Horie S, Takeuchi T,Ohta N, Homma Y, Minowada S, Nagai R, Kawabe K, Kitamura T: Effects of intracavernous
administration of adrenomedullin on erectile function in rats. Peptides, 22: 1913-1918, 2001.

Kitamura T: Necessity of re-evaluation of estramustine phosphate sodium (EMP) as a treatment
option for first-line monotherapy in advanced prostate cancer.

Int J Urol, 8: 33-36, 2001.

2000 年

Okui N, Sakuma R, Kobayashi N, Yoshikura H, Kitamura T, Chiba J, Kitamura Y: Packageable
antiviral therapeutics against human immunodeficiency virus type 1 : Virion-targeted virus
inactivation by incorporation of a single-chain antibody against viral integrase into progeny
virions. Hum Gene Ther, 11: 537-546, 2000.

Minowada S, EnomotoY, Korenaga T, Kamijo T, Homma Y, Kitamura T: CT-guided acetic acidinjection therapy for aldosterone-producing adrenocortical adenoma : a preliminary report ofthree cases. Endocr J, 47: 185-189, 2000.

Kume H, Oda H, Nakatsuru Y, Shimizu Y, Takahashi Y, Matsumoto T, Inoue S, Kameyama S,Kitamura T, Ishikawa T : Genetic idenitification of bilateral primary or metastatic nonpapillary
renal cell carcinoma.

BJU Int, 86 : 209-213, 2000.

Ikegaya H, Kato A, Matsushima H, Takai K, Hosaka Y, Kitamura T: Cystic renal cell carcinoma
diagnosed by cystofiberscopy. Int J Urol, 7: 193-194, 2000.

Ahamed H, Moriyama N, Fukasawa R, Nishimatsu H, Tanaka Y, Kitamura T, Tatemichi S,Akiyama K, Suzuki Y, Aisaka K: Contractile properties of urethral smooth muscles of young andaged female dogs : Morphological and pharmacological aspects. Int J Urol, 7: 298-306, 2000.

Kato A, Sugimoto C, Zheng H-Y, Kitamura T, Yogo Y: Lack of disease-specific amino acidchanges in the viral proteins of JC virus isolates from the brain with progressive multifocal
leukoencephalopathy. Arch Virol, 145: 2173-2182, 2000.

Homma Y, Kondo Y, Takahashi S, Kitamura T, Kawabe K: Reproducibility of cystometry inoveractive detrusor. Eur Urol, 38: 681-685, 2000.

Takahashi S, Homma Y, Fujishiro T, Hosaka Y, Kitamura T, Kawabe K: Electromyographic studyof the striated urethral sphincter in type 3 stress incontinence : Evidence of myogenic-dominantdamages. Urology, 56 : 946-950, 2000.

Muto S, Horie S, Takahashi S, Tomita K, Kitamura T : Genetic and epigenetic alteration in normal
bladder epithelium in patients with metachronous bladder cancer. Cancer Res, 60: 4021-4025,
2000.

1999 年
AokiN,Kitamura

T, Tominaga

T,

FukumoriN,

SakamotoY,

KatoK,Mori

M:

Immunohistochemical detection of JC virus in nontumorous renal tissue of a patient with renal
cancer but without progressive multifocal leukoencephalopathy. J Clin Microbiol, 37: 1165-1167,
1999.

Nishimatsu H, Takeuchi T, Ueki T, Kajiwara T, Moriyama N, Ishida T, Li Baoxing, Kakizoe T,
Kitamura T: CD95 ligand expression enhances growth of murine renal cell carcinoma in vivo.
Cancer Immunol Immunother. 48: 56-61, 1999.

Matsushima H, Goto T, Hosaka Y, Kitamura T, Kawabe K :Correlation between proliferation,apoptosis, and angiogenesis in prostate carcinoma and their relation to androgen ablation.
Cancer, 85: 1822-1827, 1999.

Ikegaya H, Kato A, Matsushima H, Takai K, Kitamura T: A case of cicatricial pemphigoid
producing severe dysuria due to labial adhesion. BJU Int, 83 : 735-736, 1999.

Azuma T, Nishimatsu H, Nakagawa T, Tomita K, Takeuchi T, Homma Y, Tajima A, Kawabe K,
Kitamura T: Metastatic renal cell carcinoma mimicking pleural mesothelioma. Scand J UrolNephrol, 33: 140-141, 1999.

Suzuki M, Hosaka Y, Matsushima H, Goto T, Kitamura T, Kawabe K: Butyrolactone I induces
cyclinB1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Cancer

Letters, 138: 121-130, 1999.

Goto T, Matsushima H, Kasuya Y, Hosaka Y, Kitamura T, Kawabe K, Hida A, Ohta Y, Simizu T,Takeda K : The effect of papaverine on morphologic differentiation, proliferation and invasive
potential of human prostatic cancer LNCaP cells. Int J Urol, 6: 314-319, 1999.

Kume H, Kameyama S, Tanaka Y, Kitamura T: Cerebellar hemangioblastoma as a late
manifestation of sporadic von Hippel-Lindau disease. J Urol, 16： 911-912, 1999.

Horie S, Aruga S, Kawamata S, Okui N, Kakizoe T, Kitamura T: Biological role of HGF/MET
pathway in renal cell carcinoma. J Urol, 161: 990-997, 1999.

Ishikawa T, Okui N, Kobayashi N, Sakuma R, Kitamura T, Kitamura, Y: Monoclonal Antibodies
against the minimal DNA-binding domain in the carboxyl-terminal region of humanimmunodeficiency virus type 1 integrase.

J Virol, 73: 4475-4480. 1999.

Nishimatsu H, Moriyama N, Hamada K, Ukai S, Yamazaki S, Kameyama S, Konno N, Ishida Y,Ishii Y, Murayama T, Kitamura T: Contractile responses to a1-adrenoceptor agonists in isolated
human male and female urethra. BJU Int, 84: 515-520, 1999.

Azuma, T., S. Kurimoto, K. Mikami, and M. Oshi. Interstitial pneumonitis related to leuprorelin
acetate and flutamide. J Urol 161:221.1999.

Azuma, T., Y. Kato, T. Suetomi, M. Nozawa, H. Kuji, and T. Kunitake. Idiopathic retroperitoneal
fibrosis presenting as duodenal obstruction. J Urol 162:1680. 1999.