Graduate School of Comprehensive Human Sciences
Degree Programs in Comprehensive Human Sciences〈Doctoral Program in Medical Sciences〉
Please contact the supervisor of your preferred field in advance, or ask the contact person to the office as
below for guidance about your choice.
Administration office for Doctoral Program in Medical Sciences
Phone: 029-853-3008
E-mail: majors.med@md.tsukuba.ac.jp〈Doctoral Program in Medical Sciences〉
Molecular Medical Sciences
Research Area

Faculty

Research

Molecular Biological
Oncology

IRIE Kenji,
HISATAKE Koji,
NISHIMURA Ken

・Using the budding yeast Saccharomyces cerevisiae as a modelorganism, we are working to elucidate the molecularmechanisms and physiological functions of the following
processes. (1) Post-transcriptional regulation of gene
expression by RNA-binding proteins. (2) Molecular mechanismof mRNA localization and local translation regulating cell
polarity, asymmetric cell division, and cell-fate. (3) Regulation of
the endoplasmic reticulum stress response by protein kinases.
(4) Prospore membrane formation by vesicle docking.
・Our research focuses on the molecular mechanisms oftranscriptional regulation, chromatin remodeling, mRNA
localization, and translational control in development anddifferentiation using biochemical, cell biological, and genetic
approaches. Roles of gene regulation in cell reprogramming anddifferentiation as well as development of an efficient system toinduce reprogramming and differentiation.

Physiological
ChemistryOHBAYASHI
NorihikoMembrane trafficking systems, which are activated by a wide
variety of agonists, such as hormones, neurotransmitters andgrowth factors, are important for homeostasis and pathogenesis.
To understand these issues, we are focussing on the projects
as follows: (1) Physiological functions of membrane trafficking
pathways and their relations with pathogenesis; (2) Roles ofmembrane trafficking pathways in neuronal functions andtumorigenesis/metastasis.
(3) Development of novel anti-cancer drugs based on membranetrafficking systems.

Molecular
Neurobiology

MASU Masayuki

Our main research focus is to study the molecular mechanismsthat regulate neural network formation and higher brain
functions using integrative approaches, which include molecularbiology, biochemistry, pharmacology, developmental biology, andneuroanatomy. Major research topics are as follows.
・Development and function of the corticospinal tract
・Regulatory mechanism of spinal motor nerve formation
・Regulation of dopamine signal transmission1Anatomy andEmbryology

TAKAHASHI Satoru

・Elucidation of molecular mechanism of pancreatic beta-celldevelopment and its application.
・Functional analysis of large Maf transcription factor family,
MafB and c-Maf in macrophage development and functions.
・Elucidating biological roles of carbohydrates using
glycosyltransferase conditional KO mice.
・Study of diseases and drug discovery by development of novel
imaging system.
・Elucidation of etiology and gene function in desease model
mice.

Anatomy and
Neuroscience

TAKEI Yosuke① Animal model studies on synaptic dysfunction inschizophrenia and autism.
② Cell-biological studies on synaptic dysfunction inschizophrenia and autism.
③ Studies on synaptic dysfunction caused by inflammation.
④ Studies on neuropsychiatric diseases caused by disrupted
intracellular tranbsport.

Molecular andDevelopmental
Biology

KOBAYASHI
MakotoStudies of following issues using zebrafish molecular genetics：
・Development of hematopoietic cells and globin switching・Anti-aging and dietary antioxidants
・Animal models for human diseases and drug safety test
・Epigenetic regulation of learing and memory
・Functions of supersulfides in animal development2

Human Medical Biology
Research Area

Faculty

Research

Laboratory Animal
Science

MIZUNO Seiya

・Development of mouse models for human diseases
・Development of genome modification technology for producing
mutant mice・Development of mouse resource including cre-driver/reporter
mice

Experimental
Pathology

KATO Mitsuyasu

Experimental study to elucidate the roles of transforming
growth factor-b-related molecules in tissue maintenance andcarcinogenesis such as stemness induction and reset of cell
division lifespan aiming for the establishment of novel moleculartargeting therapy. Multidisciplinary studies will be conducted
including, molecular cell biology, live imaging, experimental
pathology of genetically modified mice, three-dimensional
quantitative tissue analysis, mathematical modeling, and analysis
of protein structure.

Diagnostic
Pathology

MATSUBARA
Daisuke

1. Study about molecular mechanisms of multistep
carcinogenesis including precancerous or background lesions
2. Drug discovery for prevention, early diagnosis and therapy ofcarcinoma based on the genome abnormalities detected inearly carcinoma
3. Application of fetal protein to cancer diagnosis and therapy.

Immunology

SHIBUYA Kazuko

The goal of the research is to clarify the mechanisms of theimmune system which plays a major role for immune defense
against pathogens and cancer, using molecular and cellularbiology and genetic engineering. Students will also challenge tounderstand and control failured immune system such as
autoimmune diseases, allergy, and inflammatory diseases. In
addition, thorough collaboration with pharmaceutical companies
and ventures, students will leran how to translate the basic
research to drug discovery and development.

Regenerative
Medicine and Stem
Cell Biology

OHNEDA Osamu

1）The molecular mechanisms of stem cell and stromal cellinteraction is investigated related to hypoxic environment.
Based on the knowledge, basic research for regenerative
medicine will be developed toward clinical therapy in the
future.
2）The molecular mechanisms of cancer initiating cells andtumor vascularization is investigated under hypoxic
conditions.
3) In the research for clinical application of stem cells, our lab isparticularly involved in the research and development of newcell therapies using extracellular vesicles released by stem
cells.

3

Infection Biology(Molecular Virology)

KAWAGUCHI
Atsushi

We aim to understand molecular mechanisms of virus-hostinterplays which determine the pathogenicity and species
specificity of emerging infectious diseases including avian
influenza virus. We are also interested in the innate immune
response aginst virus infection.

Infection Biology(Bacteriology)

MORIKAWA Kazuya

・ Infection, adaptation, and evolutionary strategies based on
population heterogeneity.
・ Development of anti-virulence therapeutic strategies

Infection Biology(Molecular
Parasitology)

HO Kiong

We are interested in understanding the mechanism of gene
expression in protozoan parasites that is responsible for major
public health concerns, such as Malaria and sleeping sickness
disease, with a goal in identifying parasite-specific processes
that can be exploited as targets for novel therapeuticinterventions. Messenger RNA capping is an attractive target
for anit-protozoan drug development because the enzyme
responsible for cap formation is completely different between
the parasite and the human host. We also aim to understandhow damages in the RNAs are recognized and repaired in thecells. One of the few facts that have been established is thatRNA ligase - an enzyme that joins the two ends of RNA
together - is a key component of this repair process.
Understanding of the function and mechanism behind cellularresponses to RNA damage may also provide useful therapeutictargets, as breakage in the RNA accumulate in cancer cells andduring stress condition.

Neurophysiology

KOGANEZAWA
Tadachika

We are electrophysiologically approaching to mechanisms ofcardiovascular and respiratory regulation by the central nervous
system using in vivo and in situ preparation of rodents. At
present, we are especially studying that:・Cardiovascular regulation by the central nervous system
・Mechanisms of the neurogenic hypertension
・Respiratory regulation by the central nervous system

Medical Physics

KUMADA Hiroaki

1. Improving quality and reliability in X-ray and particle
radiotherapy.
2. New treatment technique using an accelerator.
3. New technique for quality control in medical applications ofradiation.
4. New calculation method to estimate proton-induced dose
distribution in the body of the patient.
5. Development of technologies for measurement and dosimetry
in particle therapy.

Biomedical
Engineering

MIYOSHI Hirotoshi

The aims of our researches are development of bioartificialorgans, e.g., ex vivo expansion systems of hematopoietic
stem/progenitor cells, bioartificial livers, and bioartificial
vascular grafts, from the viewpoint of tissue engineering.
Establishment of basic technologies required for thesedevelopments is also our interest.
4

Matrix and Stem
Cell Biology

YANAGISAWA
Hiromi,
KIMURA Kenichi-Identification and functional analysis of novel extracellularmatrix proteins of the vessel wall.
- Molecular mechanism of mechanotransduction in the vessel
wall.
- Identification of vascular wall stem cells.
- Molecular mechanism of growth and rupure of aortic
aneurysms- Identification of the niche matrix for epidermal stem cells andfunctional analysis.

In Silico Drug
DesignHIROKAWA
Takatsugu

We propose the supporting and developing of in silico drug
discovery using molecular modeling and simulation based on
fundamental technologies such as homology modeling, docking
simulation, molecular dynamics (MD) simulation, chemical
biology and cheminformatics.

5

Genome and Environmental Medicine
Research Area
Medical Genetics

Faculty

Research

NOGUCHI Emiko

Human genetics and genomics research including genome-wide
Iinkage and association analyses and epigenetic analyses.
Allergic diseases such as bronchial asthma, atopic dermatitis,
seasonal rhinitis, food allergy and autoimmune diseases are themain targets of our research. Identification of the diseasecausing mutation of genetic diseases by next generation
sequencers can be performed.
We study interactions between environments and human health,especially focusing on work environment.
・Practical research on the mechanisms of health problems
caused by workplace stress factors and the risk management
system・International collaboration with Norwegian researchers forstress coping capacity building・Research on the effects of rework program in return-to-workfrom depression

KAWASAKI Aya

Environmental
Medicine

MATSUZAKI Ichiyo

Genome Biology

MURATANI
Masafumi

Integrative genome and epigenome analysis of clinical samples
to understand mechanisms of cancer development and for
discovery of new drug targets and biomarkers.
Cell-free DNA and RNA profiling to monitor environmental
stress responses in internal tissues.

Bioinformatics

Integrated Study on
Health Information

OZAKI Haruka

Development of computational methods for interpreting massive
biological data and application of bioinformatics to biomedical
problems:(1) AI-based interpretation and prediction of genome functions(2) Development of methods for analyzing single-cell and spatial
omics data and their application to disease research(3) Basic and applied research on Research Automation(Laboratory Automation)(4) Data science research on clinical informationOHNIWA Ryosuke

We focus on issues existing in the boundary region between
Medical Science and the other academic fields, especiallystudying on the relationship between activities/fruits ofresearch and society.
(1) Studies to unravel the activities of researchers and theircommunities(2) Studies to understand the relationship between
researchers and public society(3) Studies to implement science communication(4) Studies to reconsidering the scientific methodology

6International
Community Careand LifespanDevelopment:
Empowerment
Sciences
Legal Medicine

ANME Tokie（1）Community empowerment（2）Plasticity of lifespan development and implications（3）System sciences for health social services

TAKAHASHI
Yoichiro①Development of forensic diagnostic methods based onmolecular biological techniques②Elucidation of the mechanisms of metabolism and poisoningof various toxicants③Introduction of machine learning into forensic practice④Research on medical jurisprudence and history of forensic
medicine7

Medical Science of Sleep
Laboratory

Faculty

Research

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Yanagisawa/Funato
Laboratory

YANAGISAWA
Masashi

Elucidation of fundamental mechanisms for sleep/wakeregulation①Large-scale, forward genetic screening of genes responsible
for sleep/wake regulation in mice
②Discovery and medicinal chemistry of novel drugs for sleep
disorders③Visualizig and manipulating the activity of neurons involved insleep/wake regulation

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Kutsumura/ Saitoh
Laboratory

KUTSUMURA
Noriki (★)

・Orexin receptor selective agonist/antagonist
・Opioid receptor selective agonist/antagonist
Through development such ligands shown above, we aim tocreate narcolepsy therapeutics, analgesics, and antidepressants,
etc. Not only synthesis of compounds but also pharmacologicalevaluation (in vitro and in vivo) are performed.
New drug creation by clarification of plasticity in the central
nervous system and change of emotional brain function induced
by stress, chronic pain and drugs of abuse.

SAITOH Tsuyoshi

We use organic chemistry to create innovative molecules
contributing to biomedical sciences, such as:1) Drugs targeting GPCRs such as orexin, adenosine, and opioid
receptors
2) Novel chemical probes to visualize biological functions3) Opto-pharmacological probes for the flexible control of drug
function
4) New chemical reactions using electron and photon as
external energy.

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Sakaguchi
Laboratory

SAKAGUCHI
Masanori

1) Elucidation of the role of sleep in memory processing2) Developing a new therapy for PTSD using sound stimulation
during sleep3) Role of hippocampal cellular plasticity during sleep

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Lazarus/Oishi
Laboratory

LAZARUS Michael

1) Understanding the link between sleepiness and motivation by
exploring mesolimbic glia-neuron interactions
2) Sleep circuits as potential therapeutic targets for insomnia
3) Adenosine A2A receptor function in schizophrenia
4) Solving the mystery of immune regulation by sleep with singlecell RNA sequencing

OISHI Yo

1) Sleep regulation by dopamine-related neural circuits
2) Production and analysis of short-sleeper mice3) Relationship between anti-histamine and sleepiness8

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Greene/Vogt
Laboratory

VOGT Kaspar

Analysis of neural circuits dynamics in awake and sleeping
animals using in-vivo electrophysiology and functional imaging.
We are focusing on the cortical neural networks producing deep,
so called slow-wave sleep and the mechanisms of its
homeostatic regulation. Ultimately we want to understand thevital, restorative effect of deep sleep on brain function.

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
T Sakurai/Hirano
Laboratory

SAKURAI Takeshi,
HIRANO Arisa,
SOYA Shingo1) Elucidation of the function and neural circuits that regulate
sleep/wakefulness states.
2) Elucidation of the function and neural circuits that regulateemotion and emotional memory3) Exploration of biologically active substances that regulateemotion and sleep/wakefulness states
4) Functional and behavioral analysis of the circadian clock
system.
5) Analysis of the systems that regulate body temperature andmetabolism

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Honjoh Laboratory

HONJOH Sakiko

1) The dynamics of thalamocortical system across sleep/wakecycles2) Elucidation of neural circuits underlying NREM sleep specific
EEG patterns
3) Analysis of vigilance state-depedent transcriptional changes4) Elucidation of the function of vigilance-state specific genes
in neural activity

International
Institute forIntegrative Sleep
Medicine(WPI-IIIS)K Sakurai
Laboratory

SAKURAI
Katsuyasu

International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Toda Laboratory
International
Institute forIntegrative Sleep
Medicine(WPI-IIIS)
Shi Laboratory
International
Institute forIntegrative Sleep
Medicine (WPI-IIIS)
Abe Laboratory

TODA Hirofumi

SHI Shoi

ABE Takashi

1) Functional analysis of the sexual behavior related neuralcircuits
2) Functional analysis of the pain related neural circuits3) Functional analysis of the sleep related neural circuits4) Functional analysis of the emotion related neural circuits5) Functional analysis of the sensory system related neuralcircuits
Understanding of molecular mechanisms for sleep(1) Genetic behavioral screen using Drosophila(2) Understanding of the molecular pathways and neuronal
network that a novel sleep-inducing factor function in(1) Theoretical biology of sleep(2) Comparative biology of sleep(3) Population level homeostasis in scoial insect, ants

(1) Functional roles of human sleep(2) Neurobehavioral consequences of sleep deprivation(3) Development of non-invasive methods to improve humansleep(4) Development of new methods to evaluate human sleep andwakefulness

The star (★) indicates the supervisor needs to instruct students with another supervisor without (★).
9

Clinical Pathogenesis
Research Area

Faculty

Research

Diagnostic andInterventional
Radiology

NAKAJIMA Takahito

In diagnostic imaging, such as CT, MRI, ultrasound and nuclear
medicine, we are engaged in the search for new insights, image
analysis using artificial intelligence (AI) and radiomics, andradiogenomics, which combines genomic information with imaging.
As research on a wide range of diseases from tumors to
inflammation is encouraged, even those who specialize in fields
other than diagnostic radiology can conduct research indiagnostic imaging using their individual expertise. In addition,clinical research using interventional radiology (IVR) will bepromoted, and guidance and an environment will be provided forradiologists who wish to pursue research using IVR, as well asbasic research on large animal photoimmunotherapy using IVR
techniques.

Radiation Oncology

SAKURAI Hideyuki

We investigate on radiobiological, physical and engineering
aspects of radiotherapy with either heavy particles orconventional radiations (photons and electrons). Emphasis isplaced on basic researches on proton therapy which is being
practiced at the Proton Medical Research Center, University ofTsukuba.

Radiation Health Risk
Science

ISOBE Tomonori

Responses in each time phase of radiation disasters are crucial
such as an emergency radiation medicine in the aftermath, andcontinuous physical/mental healthcare, radiation evaluation andrisk preperation in the recovery period. In this course, research
topics are widely opened to which are related to radiation
measurement, protection, health risk management and risk
communication aiming for developping new techniques or toestablish evidence.

Psychiatriｙ

ARAI Tetsuaki,
SATO Shinji（※）

On the basis of the knowledge regarding mental functions, weare engaged in the clinical practice for the patients withdementia, schizophrenia, affective disorders, eating disorder andother psychiatric illnesses. In order to elucidate the etiology ofthese neuropsychiatrical illnesses, we continue a series of basic
and clinical studies from biological and psychological viewpoints,
using neuropathology, neurochemistry and neuroimaging,
epidemiology and social psychiatry.

［ARAI Tetsuaki］

Disaster andCommunity
Psychiatry

TACHIKAWA
Hirokazu

The main focus of our research activities is how to maintainmental health for disaster victims and rescue personnel after alarge-scale disaster takes place. Community mental healthissues such as suicide prevention, outreach, psychiatricemergency system, or Lieson psychiatry are also studied.

10Anesthesiology（）

Research field covers clinical physiology and pharmacology ofvital organ systems including respiration, circulation, energy
metabolism, and central nervous system under surgical ortraumatic stress. The effect of anesthesia on responses tothese stresses is also studied.
We also study cardio-pulmonary-cerebral resuscitation andmaintenance of life during cardiac arrest.

Emergency andCritical Care
Medicine

INOUE Yoshiaki

1) Clinical and basic research on emergency medicine,
multiorgan failure, and toxicology to develop novel treatment
strategies.
2) Research on emergency medical system, triage, and disastermedicine.

Pharmaceutical
Sciences

HONMA Masato

Clinical pharmacokinetics for evaluating drug efficacy andadverse reactions.
1) Pharmacokinetic analysis for drug disposition
2) Assessing the drug metabolizing enzymes and drugtransporters
3) Assessing adverse events including drug interaction inpharmacotherapy

Primary Care andMedical Education

MAENO Tetsuhiro,
YOKOYA Shoji①Clinical research in primary care
②Development of community-based medical system③Health promotion in the community④Clinical medical education

Palliative andSupportive Care

KIZAWA Yoshiyuki①Clinical research in pallitive and supportive care especially for
symptom management and communication including advancecare planning②Development of effective delivery systems for palliative care
③Quality assurance and improvement of specialist palliative
care④Education in palliative care

Clinical Trial andClinical
Epidemiology

WAGATSUMA
YukikoClinical epidemiology has been evolved in modern medicine.
That helps to understand the conceptual gaps between
structured experience of basic science and the more complex,
open-ended problems arising for the care of patients. Based on
the principals of clinical trial and the use of clinicalepidemiology, we tried to provide the evidence towards
improving the care of the patients.

GOSHO Masahiko

Research field covers biostatistics for medical studies. To solve
statistical issues arising in the process of the design, conduct,analysis, and evaluation of medical studies, we develop novel
statistical methods and evaluate the performance of themethods.

Biostatistics

11

Clinical andTranslational
Research
Methodology

HASHIMOTO Koichi① Regulatory science② Clinical trilas for functional foods③ Improvement of efficiency of practical medicine using AI
and IOT④ Construction of seamless platform for translational
research

Clinical Researchand Regional
Innovation

MASUDA Noriyuki①Investigation and research on cases aimed at promoting homecare and remote medical care.
②Promotion of pre-clinical research aimed at developing medical
devices, etc.
③Promotion of clinical research aimed at developing medical
devices, etc.

※This mark indicate specific supervisor.
Please write the name of supervisor mentioned in bracket as the Sub-Supervisor in the form.

12

Clinical Surgery
Research Area

Faculty

Research

Gastrointestinal andHepato-biliarypancreatic Surgery

ODA Tatsuya1) Elucidating the molecular mechanisms of the genesis &invasion/metastasis of intractable pancreatic cancer. (3D
organoid research, cancer microenvironments, cancer
associated fibroblast/ immune cells)2) Development of new diagnositic marker for pancreatic cancer(bran new glycanmarkaer in serum, exosome, cell free DNA)
3) Development of new treatment strategy for pancreaticcancer (Novel cancer treatmengt by using lectins(carbohydrate recgniizing protein) as a drug carrier, targetingcancer cell suface glycans.
4) Research on 1)-3) against various GI & HBP Surgery.
5) Precision medicine for sugegical patients.

Cardiovascular
Surgery

HIRAMATSU Yuji,
SUZUKI Yasuyuki

Student is expected to become an internationally compatible
research physician in cardiovascular surgery by understanding
pathophysiology of cardiovascular system and acquiring
sufficient laboratory skills.

Orthopedic Surgery(

Clinical and basic research on following themes is presented:
treatment of spinal disorders, regeneration of peripheral nerve,
treatment of osteoarthrosis, regeneration of joint cartilage,
artificial knee and hip joints and reconstruction of ligaments.

General Thoracic
Surgery

SATO Yukio,
ICHIMURA Hideo

This course is programmed to investigate on1) minimal invasive thoracoscopic surgery for lung cancer, 2)angiogenesis and invasion of lung cancer, 3) leukocytesendothelial interaction in acute lung injury, 4) novel sealantmaterial for surgery and 5) screening of lung cancer withexhaled breath and 6) surgical simulation, and estimation of
postoperative lung regeneration and function using 3D-CT.

Pediatric Surgery

MASUMOTO Koji

In this course, the bioengineered tissue studies using biomaterials
are planned for students regarding treatments of severe
hypoplastic lungs in congenital diaphragmatic hernia. In addition, if
the students would like to study concerning malignant solid
tumors in children, we will provide the study program focusing on
genetic aberrations related to carcinogenesis and progression ofthem.

Urology andAndrology

NISHIYAMA Hiroyuki

In this course, the etiology of various urological diseases arestudied by means of molecular-biological, morphological,
pathophysiological and epidemiological methods. The students
are requested to consider the clinical problems concerning
prevention, diagnoses, treatments of urological diseases andquality of life, and to plan and perform research projects inproblem oriented manner)

13

Plastic andReconstructive
Surgery

SEKIDO Mitsuru

Research of tissue change after free flap transfer, woundhealing, and process of functional recovery. Research ofadequate tissue, quantity and nature for reconstructive surgery

HARA Hisato

Resurch about the hardnes of Breast and Endocrine tumor byelastography.

Obstetrics andGynecology

SATO Toyomi,
HAMADA Hiromi

The program is designed to learn the physiology (anatomy,
menstrual cycle, maternal and fetal physiology, delivery) and thepathology (maternal and fetal diseases and gynecologic
diseases) of female genital organs and to conduct
researches/experiments for these conditions and diseases.

Neurosurgery

ISHIKAWA Eiichi,
MATSUMARU Yuji

1) Neurooncology1)-1 Neurooncology(Advanced Therapeutics): Boron neutron
capture therapy(BNCT), Proton therapy, Tumor vaccination,
Gene thrapy, Photodynamic diagnosis and treatment (PDD,
PDT)
1)-2 Neurooncology(Diagnostics): Molecular maker and gene
analysis of brain tumor(glioma, pediatric brain tumor,
craniopharyngioma), Intraoperative neurophysiologicalmonitoring (MEP, SEP, EEG), Imaging study(Intraoperative
MRI, Tractography, PET)
2) Cerebrovascular disease: Neuroprotection using
nanoparticle and stem cell therapy for ischemic stroke.
Prevention of carotid artery restenosis. Evaluation ofoxidaive stress in brain.
3) Analysis of cerebral function, perfusion and metabolism
using neuroimaging (functional -MRI, MR spectroscopy,
diffusion tensor imaging, PET)
4) Neurorehabilitation using Robot Suit HAL, Brain machineinterface5) Functional neurosurgery for epilepsy, involuntary movement,
central pain and Headache
6) Gene therapy and regeneration therapy using DDS(Angiogenesis, bone regeneration)7) Pediatric Neurosurgery: Epigenetic biomarkers from woman
with neural tube defect affected pregnancies8）Development of advanced medical equipment and device(laser endoscope, new device of endoscopic surgery)

Visual Science andOphthalmology

OSHIKA Tetsuro

The course delves into the structure and function of the visualapparatus, the physiological processes behind vision formation,
factors affecting vision, and the mechanism and pathology ofvisual impairments. It also encompasses clinical andexperimental research on various visual disturbances.

Breast andEndocrine
Surgery14

Otolaryngology &Head and Neck
Surgery

TABUCHI Keiji

The pathogeneses of the various diseases in otology and neurootology are investigated with the pathophysiological,
electrophysiological and molecular biological methods.

Oral and Maxillofacial
Surgery

BUKAWA Hiroki,
YANAGAWA Toru（※）

The aim of our research is to study the relationship between
the morphology and function of the oral and maxillofacial region
by experimental and clinical approaches, and to investigate themorphological and functional disorders related to the cause
andlocation in disease of oral the and maxillofacial region.

［BUKAWA Hiroki］
Rehabilitation
Medicine

HADA Yasushi

This program is designed to learn various fields related torehabilitation medicine (disability medicine, clinicalneurophysiology, prosthetics and orthotics), and conduct clinicalresearch related to rehabilitation medicine through Medical
engineering cooperation, robot rehabilitation, disabled sports
medicine.

※This mark indicate specific supervisor.
Please write the name of supervisor mentioned in bracket as the Sub-Supervisor in the form.

15

Clinical Medicine
Research Area

Faculty

Research

Gastroenterology

TSUCHIYA Kiichiro

We will try to elucidate the pathophysiology and develop novel
therapy for intractable digestive diseases including inflammatory
bowel disease and malignant tumors by molecular biological andregenerative medicine methods. In addition, we will practiceclinical science that integrates basic and clinical research byutilizing clinical information and samples.

Cardiovascular
Medicine（）

Research for etiology, pathophysiology, prevention andmolecular biology of cardiovascular diseases. Clinical andexperimental studies for pathophysiology of cardiovasculardiseases, pharmacological and non-pharmacological treatments
and further prevention of the diseases.

Pulmonology

HIZAWA Nobuyuki

Clinical and basic research for regulation of airway inflammation
and remodeling. Molecular biology and genetic epidemiology ofchronic obstructive pulmonary disease, asthma and interstitial
pneumonia. Clinical studies on lung cancer.

Neurology

SAIKI Shinji

Molecular pathogenesis of Alzheimer’s disease, Neurobiology ofdegenerative disorders, Gene therapy for muscular dystrophies,
Neuroimmunology, Neurophysiology, Clinical Neurology,
Organoarsenic intoxication.

Nephrology

YAMAGATA
Kunihiro

The mechanisms of the progression and therapeutic approaches
for the renal diseases will be lectured from viewpoints ofpathology, immunology, biochemistry, physiology, molecularbiology, byoinfomatics and clinical epidemiology. Based on thecurrent information, experiments to clarify unknown problems
are planned and performed with our well-trained lecturers.

Hematology

SAKATA Mamiko,
OBARA Naoshi

We focus on mechanisms of normal hematopoiesis and bloodcancers, and aim at developing new therapeutics. The students
acquire necessary techniques required for carrying out theirown research under an appropriate plan. Those techniques
cover wide range of fields such as cell biology, molecularbiology, biochemistry, animal studies, genome science,
bioinformatics, and clinical studies.

Clinical Immunology

MATSUMOTO Isao

The purpose of our research is to reveal the molecular mechanismof autoimmune diseases such as rheumatoid arthritis, Sjögren’s
syndrome, and systemic lupus erythematosus by immunological andmolecular biological approaches. The final goal is to establish thedisease-specific treatments targeted on the molecules which play
important roles in pathogenesis of autoimmune diseases.

16

Metabolism andEndocrinology

SHIMANO Hitoshi,
MATSUZAKA
TakashiInvestigation of the molecular mechanisms of pathophysiology ofenergy metabolism and endocrinological homeostasis focusing on
diabetes, dyslipidemia, obesity, atherosclerosis, NASH,
neuropsyciatric diseases and endocrine diseases will lead us tonovel strategies and therapies of various diseases.
You can learn molecular and biological technology of gene
regulation and multi-omics, and experience mystery of life and joyof research through both cell and animal experiments with a wide
variety of organs including liver, pancreatic beta cells, adipocytes,
skeletal muscle and brain.

Clinical Laboratory
Medicine

KAWAKAMI Yasushi

Pathophysiological study on human diseases (lifestyle-relateddisease, malignant tumor, genetic disease or infectious disease)using the techniques of genetic analysis containing SNP and
DNA microarray for the purpose of screening and diagnosis.

Dermatology

NOMURA Toshifumi

We aim to unveil hitherto-unknown pathomechanisms of genetic
skin diseases to offer novel therapeutic strategies for thepatients.

Pediatrics and Child
HealthTAKADA Hidetoshi

The purpose of our research is to
1. Investigate the physiologic and pathologic processes ofgrowth and development in terms of molecular mechanism inembryogenesis, differentiation, apoptosis and regeneration.
2. Create methods on the basis of the above results to improve
human health and control diseases.
3. Cultivate researchers who can apply ideas of bioethics to
improve quality of lives of infants and children.

Infectious Diseases

SUZUKI Hiromichi,
HITOMI Shigemi

1. Epidemiological investigation of serious infectious diseases
and HIV infection.
2. Molecular investigation of pathogenic and drug-resistantfactors of microorganisms.
3. Evaluation of precautions against transmissible infections
diseases.
4. Clinical studies among patients with infectious diseases

Medical Oncology

SEKINE Ikuo

This course provides pathological, biological and clinicalapproaches to the etiology, pathophysiology, diagnosis andtreatment of malignant diseases. Based on the current
knowledge, the theme of research is discussed and determined.

Biomedical
Informatics andManagement

OHARA Makoto

①
②
③
④

Research for standardization and interoperability of
medical information
Research for medical safety, patient safety, and quality of
medical care.
Epidemiological and clinical research using DWH of EHR.
Research for the mechanism of medical care itself

17

Molecular Sportology

TAKEKOSHI
Kazuhiro① Personalized treatment for exercise through using genetic
information② Research for anti-doping③ Exercise and hormone, especially catecholamine④ Exercise and stress marker, especially salivary Chromogranin
A (collaborated with Prof. Omori)CancerImmunotherapy and
Immunology

KANEKO ShinOur research covers basic and applied sciences related to Tcell-based cancer immunotherapy including researches to
explore new cancer targets, to analys anti-tumor mechanismsof immune cells, to improve T-cell functions through genemanipulation and iPSC-based rejuvenation, and to develop
manufacturing process for practical application of immune celltherapy.

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Social Medicine
Research Area

Faculty

Research

Health Services
Research

TAMIYA Nanako,
SUGIYAMA Takehiro

Empirical research (health services research) for quality
improvement of health services including health promotion,
medical care, and long-term care
Quality indicator and standardization of medicine
health promotion, medical care, and long-term care in thecommunity (community-based integrated care systems)
Prevention, early detection, and complication prevention ofdiabetes and other NCDs, and translation into guidelines andhealth policy
Emergency intensive care (especially for the elderly, trauma,
resuscitation, etc.)
Health services research in clinical departments such as
rehabilitation, pediatrics, geriatrics, palliative medicine, etc.

Health Care Policyand Health
Economics

KONDO Masahide

Studies on health care policy and health system
Studies on health economics
Studies on disese control measures19

【Cooperative Graduate School】(Sub) indicates the Sub-Supervisor.
Research Area
Cell Engineering(RIKEN)

Faculty

Research

NAKAMURA Yukio,
HAYASHI Yohei

Cell engineering technologies are developing very rapidly, e.g., thetechnology to generate iPS cells, direct conversion ofdifferentiated cells to another lineage, genome editing by
CRISPR/Cas9 and so on. We perform the following researches.
#. Standardization of generation of iPS cells and maintenance of
iPS cells#. Researches for effective utilization of iPS cells derived frompatients (which is called disease-specific iPS cells or patientspecific iPS cells)#. Generation of novel cell lines such as those immortalized at thestages of hematopoietic stem/progenitor cells, erythroid progenitor
cells and so on#. Development of new ways for utilization of conventional humancancer cell lines using genome editing technology and so on.

[(Sub)TAKAHASHI
Satoru ]International
Medicine(NCGM)

Virology(NIID)

Genomics-based
Drug Discovery(Eisai)KANO Shigeyuki

To conduct the researches on International Medicine of global
importance particularly on emerging and re-emerging infectious[(Sub)KAWAGUCHI diseases which require international cooperation for their
Atsushi ]containment. Such socio-economic researches on human behavior
or habitat, population movement, ecological or environmental
factors are also indispensable for the control of the disease. Many
issues for the achievement of the “Sustainable Development Goals(SDGs)” such as poverty, hunger, malnutrition, education, watersafety, gender discrimination, vaccine or drug production in thecontext of Global Health are to be clarified and resolved toaccelerate the “Universal Health Coverage (UHC)”.
TAKAHASHI
Yoshimasa･We aim to clarify immune evading approaches that are utilized by
rapidly mutating viruses, and to clarify how the immune responses
counteract the viral escapes.
[(Sub)KAWAGUCHI ･We rationally design therapeutic antibodies and vaccines byAtsushi ]combining the immune profiling, structural biology, and computerscience.
MIYAMOTO
Norimasa[(Sub)MORIKAWA
Kazuya]Functional genomics and pharmacological methods are used toelucidate the mechanisms of how disease targets molecules related
to the disease. These methods are also used to understand druginduced side effect mechanisms. Pharmacokinetics and drug
metabolism mechanisms are being studied for novel drugcandidates. Innovative in vitro and in vivo non-clinical study models
are established after elucidation of the relationship of the drug
target molecule and the disease or the drug candidates and theirside effects in order to verify human prediction accuracy and thevalidity of introduction to clinical study. Various human stem cellderived cells are used for research in clinical prediction.

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Celluar andMolecular
Biotechnology
Research Institute（AIST）KUNO Atsushi(Kuno) Molecular and Cellular Glycoproteomics Research Group

SUMARU Kimio(Sumaru) Applied Molecular Function Research Group
Novel in vitro physiological models are developed by applying onplate cell processing technology and new cell culture systemcomposed of microstructured functional polymers as scaffolds tovarious cells including desease-specific iPS cells.

TATENO Hiroaki(Tateno) Multicellular Systen Regulation Research Group
Using a new multi-omics analysis technology that simultaneously
measures glycans and RNA at the single cell resolution, we analyze
the microbiome, cancer cells, stem cells, etc. We aim to clarify
cellular heterogeneity and develop novel drugs and diagnostic
agents.

【(Sub)ODA
Tatsuya】
SATO Junko

Pharmaceuticals
Based on regulatory science, we investigate benefit/risk balance ofand Medical Devices
medical products for regulatory approval, and also approprote risk
Science【(Sub)HASHIMOTO management in timely manner.
（PMDA）
Koichi】
Translational
NARAOKA Hitoshi We implement translational science that leads to discovery of
Science on Druginnovative medicines meeting unmet medical needs. We investigate
Discovery[(Sub)MORIKAWA more direct and effective connection between basic research and(API)
Kazuya]patient care in the clinical stage through research ofpathophysiology & toxicology, and development/qualification ofnovel methodologies such as microphysiological systems and so on.

(RIKEN)＝RIKEN Tsukuba Research Laboratories(NCGM)＝National Center for Global Health and Medicine(NIID)＝National Institute of Infectious Diseases(Eisai)＝Eisai Co. Tsukuba Research Laboratories（AIST）＝National Institute of Advanced Industrial Science and Technology（PMDA）＝Pharmaceuticals and Medical Devices Agency(API)＝Astellas Pharma Inc

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