Handling of Contract in Preparation of Genetically Modified Mice by Laboratory
Animal Resource Center, University of Tsukuba
Established on January 28, 2002

(Objective)
1. This handling shall stipulate matters required for preparation and supply of genetically modified
mice (hereinafter referred to as “preparation”) by Laboratory Animal Resource Center in ouruniversity (hereinafter referred to as “Consignee”) in accordance with the stipulations in Rules ofContract in Preparation of Genetically Modified Mice in Laboratory Animal Resource Center,Tsukuba University (Rules No. 1, 2002. Hereinafter referred to as “Contract Rules”), Article 6.

(Submission)
2. Those who desire to consign preparation of genetically modified mice (hereinafter referred to as“Consignor”) shall submit the Submission Form for Preparation and Supply of Genetically Modified
Mice referred to in the Contract Rules, Article 3, Paragraph 1, after checking this handling and theseparately established usage guidance.

(Payment of fees pertaining to preparation)
3. Consignor shall pay the fee stipulated in the appended table of the Contract Rules by the datedesignated by the notice of payment issued by Revenue Collector of our university, upon receipt ofthe Letter of Notice of Contract Decision for Preparation and Supply of Genetically Modified Micereferred to in the Contract Rules, Article 3, Paragraph 2. Paid fees are not refundable.
4. Consignor shall pay the designated arrears according to the days from the next day of the due dateto the date of payment when the fee referred to in the preceding paragraph is not paid by thedesignated due date.

(Attribution of equipments purchased by use of fees pertaining to preparation)
5. Equipments purchased by use of fees pertaining to preparation shall attribute to Consignee.

(Bearing expenses pertaining to transportation)
6. Consignor shall bear expenses pertaining to transportation of DNA samples or ES cells submitted

by Consignor, and of genetically modified mice supplied by Consignee.

(Commencement of preparation)
7. Consignee shall commence preparation of genetically modified mice after confirmation ofpayment of the fee pertaining to the preparation, etc. and upon submission of DNA samples or EScells.
8. Consignor and Consignee may not unilaterally cancel submission of DNA samples or ES cells,and preparation of genetically modified mice, respectively, after payment of the fee.
9. Consignee shall securely dispose the submitted DNA samples or ES cells by the designatedmethod and shall not use them for other purposes when preparation of genetically modified mice iscompleted.
10. Consignee shall not publish the detail of the requests.

(Exemption to damages)
11. In the case any damage occurs due to DNA samples or ES cells submitted by Consignor, orgenetically modified mice supplied by Consignee, neither of the parties is questioned about theresponsibility except the case there has been gross negligence.

(Publication of research achievements)
12. In the case of publishing research achievements obtained by use of the supplied geneticallymodified mice in an article, etc., Consignor shall clearly mention that the genetically modified mice
were prepared in Laboratory Animal Resource Center, Tsukuba University and send a copy ofreprint of the article to Consignee.
13. In the case of application for a patent, etc. with regard to the supplied genetically modified mice,
both parties shall take consultation together.
14. Consignor shall make an effort in widely providing the supplied genetically modified mice forthe use by researchers, including deposition with public resource centers, etc., after publication of
the research achievements obtained by use of the genetically modified mice.

(Others)
15. Matters not stipulated in this handling but required for contract in preparation, etc. of geneticallymodified mice shall be subject to individual consultation for the decision.