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Cambridge Isotope Laboratories, Inc.
isotope.com

Deuterated Reagents
For Pharmaceutical andSynthetic Applications

Cambridge Isotope Laboratories, Inc. (CIL) offers over 15,000 stable isotope-labeledproducts for your synthetic applications, including the manufacturing of APIs. Many labeling
patterns are available for common starting materials. For more than 38 years, CIL has offered:•	Expertise and quality service from initial quote request through delivery•	Flexibility of scale for custom and catalog products from milligram to multikilogram quantities•	cGMP capabilities for manufacturing raw materials and bulk APIs

In recent years, some pharmaceutical companies have begun toinvestigate deuteration of molecules that may provide advantages
over their existing nondeuterated counterparts. In addition,
increasing research into the potential medical benefits of newdeuterated drugs is also occurring. The potential advantagesof deuterated pharmaceuticals include:
Improved metabolic profile. The improved metabolic profile may
potentially reduce or eliminate unwanted side effects or undesirable
drug interactions.

Improved oral bioavailability. Deuteration in some compoundshas reduced the presystemic metabolism that occurs in the digestive
track, allowing more of the unmetabolized drug to reach its target.
Increased half-life. Deuterated compounds can have a slower
pharmacokinetic effect, extending the absorption and distribution
in the body. This may decrease the number of doses a patient may
require in certain time period compared to its nondeuterated
counterpart.

Catalog No.

Description

Catalog No.

Description

DLM-112
DLM-12RG*
DLM-1556
DLM-1162
DLM-9RG*
DLM-247
DLM-855

Acetaldehyde-d (D, 99%)
Acetic acid-d4 (D, 99%)
Acetic acid-d (D, 98%)
Acetic anhydride-d6 (D, 98%)
Acetone-d6 (D, 99.5%)
Acetyl chloride-d3 (D, 98%)
Acrylic-2,3,3-d3 acid (D, 98%)(+ 0.1% 4-methoxyphenol) <5% H2O
Ammonium deuteroxide-d5 (D, 99%) ~25% sol in D2O
Aniline-ring-d5 (D, 98%)
Benzene-d6 (D, 99%)
Biphenyl-d10 (D, 98%)
Borane-d3 (D, 98%) (1 molar in THF) (+0.005M NaBD4)
Borane-d3 methylsulfide complex (D, 98%)
(contains 10% additional dimethylsulfide)

DLM-398
DLM-874
DLM-181
DLM-1664
DLM-10515
DLM-1116
DLM-263
DLM-7RG*
DLM-337
DLM-1560
DLM-2781
DLM-1003DR
DLM-408DR

Bromobenzene-d5 (D, 99%)
Bromoethane-d5 (D, 98%)
1,4-Butanediol-2,2,3,3-d4 (D, 98%)
t-Butanol-d10 (D, 98%)
t-Butyl acetate-d9 (D, 99%)
t-Butyl chloride-d9 (D, 98%)
Chlorobenzene-d5 (D, 99%)
Chloroform-d (D, 99.7%)
Chloromethane-d3 (D, 99%)
Cyclohexanone-d10 (D, 98%)
Cyclopentyl bromide-d9 (D, 98%)
Deuterium (D, 99.96%) <400 ppm HD
Deuterium (D, 99.8%) (D2, 99.6% + HD, 0.4%)

DLM-710RG*DLM-862
DLM-1RG*
DLM-494
DLM-1315
DLM-4747*RG = reagent grade CP = chemical purity

Continued ➤Cambridge Isotope Laboratories, Inc.
North America: 1.800.322.1174 cilsales@isotope.com | International: +1.978.749.8000 intlsales@isotope.com | fax: 1.978.749.2768 | isotope.com

| Deuterated Reagents

Cambridge Isotope Laboratories, Inc.

Catalog No.

Description

Catalog No.

Description

DLM-458DR
DLM-3DR

Deuterium chloride (D, 99%)
Deuterium chloride (D, 99.5%)
DCl 35% w/w solution in D2O
Deuterium chloride (D, 99.5%)
DCl 20% w/w solution in D2O
Deuterium oxide (D, 99.8%)
Deuterium oxide (D, 99.9%)
1,2-Dibromoethane-d4 (D, 99%)
1,3-Dibromopropane (D6, 98%)
1,2-Dichlorobenzene-d4 (D, 99%)
Dimethyl-d6-amine·HCl (D, 98%)
Dimethyl carbonate-d6 (D, 99%)
Dimethyl sulfate-d6 (D, 98%)
Dimethyl sulfoxide-d6 (D, 99.9%)
N,N-Dimethylformamide-d7 (D, 99.5%)
N,N-Dimethylformamide (formyl-D, 98-99%)
Ethanol-OD (D, 99%) <6% D2OEthanol-d6 (D, 99%) anhydrous
Ethanol-d6 (D, 99%) 5-6% D2O
N-Ethylaniline-d10 (D, 98%)
N-Ethyl-d5-aniline (D, 98%)
Ethylene-d4 (D, 98%)
Formaldehyde-d2 (D, 98%) ~20% w/w in D2O
Formic acid-d2 (D, 98%) <5% D2OFormic acid (formyl-D, 98%) <5% H2O
n-Heptane-d16 (D, 98%)
Iodoethane-d5 (D, 99%) + copper wire
Iodoethane-1,1-d2 (D, 98%) + copper wire
Iodoethane-2,2,2-d3 (D, 98%) + copper wire
Isopropanol-d8 (D, 99%)
a-Ketoglutaric acid (3,3,4,4-D4, 98%) CP 90%
bis(2-Chloroethoxy)-d8 methane (D, 98%)
Methanesulfonic acid-d4 (D, 97-98%)

DLM-24RG*DLM-15
DLM-10186
DLM-23RG*
DLM-1500DR
DLM-289
DLM-10488

Methanol-d4 (D, 99.5%)
Methanol-OD (D, 99%)
Methylboronic acid (methyl-D3, 98%) CP >90%
Methylene chloride-d2 (D, 99.8%)
Methyl-d3-amine (D, 98%)
Methyl-d3-amine·HCl (D, 98%)
Methyl-d3 magnesium iodide (D, 99.5%)
2.0 M in di-N-butyl ether
Methyl-d3 methanesulfonate (D, 98%)
Methyl formate (formyl-D, 99%)
Methyl iodide-d3 (D, 99.5%) + copper wire
Morpholine-2,2,3,3,5,5,6,6-d8 (D, 98%)
2-Nitrophenol-ring-d4 (D, 98%)
4-Nitrophenol-ring-d4 (D, 98%)
Octanoic acid-d15 (D, 98%)
Paraformaldehyde-d2 (D, 99%)
Phenol-d6 (D, 98%)
Phenyl-d5-boronic acid (D, 98%)
Phthalic anhydride-d4 (D, 98%)
Pivalic acid-trimethyl-d9 (D, 98%)
N-Propanol-d7 (D, 98%)
Pyrrolidine-2,2,3,3,4,4,5,5-d8 (D, 98%)
Sodium borodeuteride-d4 (D, 99%) CP 90-95%
Sodium deuteroxide (D, 99.5%) 40% in D2O
Sodium formate (D, 98%)
Sodium 2,2-dimethyl-2-silapentane-5-sulfonate-d6 (DSS)(D, 98%)Sulfuric acid-d2 (D, 99%) 96-98% in D2O
Tetrahydrofuran-d8 (D, 99.5%)
Tetramethylsilane-d12 (D, 98%)
Toluene-d8 (D, 99.5%)
Trifluoroacetic acid-d (D, 99%)

DLM-2
DLM-4DR-99.8
DLM-4DR
DLM-195
DLM-6020
DLM-158
DLM-265
DLM-3903
DLM-196
DLM-10RG*
DLM-25
DLM-1670
DLM-16
DLM-31
DLM-31RG*
DLM-9660
DLM-9626
DLM-347
DLM-805
DLM-286
DLM-743
DLM-423
DLM-272
DLM-1023
DLM-1024
DLM-44
DLM-6201
DLM-1945
DLM-1981

DLM-9707
DLM-651
DLM-362
DLM-3484
DLM-295
DLM-296
DLM-619
DLM-300
DLM-370
DLM-10858
DLM-788
DLM-9813
DLM-3078DR
DLM-9662
DLM-226
DLM-45DR
DLM-1361
DLM-8206
DLM-33DR
DLM-36
DLM-2729
DLM-5RG*
DLM-46RG**RG = reagent grade CP = chemical purity

Multiple sizes and quantity
discounts are available;please inquire.

Research products are distributed and sold worldwide via our extensive network.
CIL’s distributor listing is available at isotope.com.
To request a quotation or place an order:
North America: envsales@isotope.com | 1.978.749.8000 | 1.800.322.1174 | cilsales@isotope.com
International: intlsales@isotope.com | +1.978.749.8000 | intlsales@isotope.com
Fax: 1.978.749.2768 | isotope.com

Enriching Scientific Discovery

Cambridge Isotope Laboratories, Inc. 3 Highwood Drive, Tewksbury, MA 01876 USA
North America: 1.800.322.1174 | International: +1.978.749.8000 | fax: +1.978.749.2768 | isotope.com

DEUT_RSCH_REAG (9/17/20)
Supersedes all previously published literature