CO1-1

Boron Neutron Capture Therapy for Malignant Brain Tumors
Using Epithermal Neutron

S. Miyatake, S. Kawabata, R. Hiranatsu, Y. Hirota
T. Kuroiwa, Y. Sakurai1, H. Tanaka1, A. Maruhashi 1,M. Suzuki1, N. Kondo, S. Masunaga1, Y. Kinashi1 andK. Ono1
Department of Neurosurgery, Osaka Medical College
1
Research Reactor Institute, Kyoto University

INTRODUCTION: Between June 2012 and Februarry
2013, we applied BNCT using epithermal neutron for1) newly diagnosed GBM (4 cases),2) recurrent malignant gliomas (4 cases)3) high-grade meninigiomas (HGM)(6 cases).
These BNCT were applied in KUR.
Here we reported our results of BNCT on 20 consecutive
HGMs from 2005 to 2011, which were observed morethan a year, after BNCT [1,2].
METHODS: The patients were administered 500 mg/kg
of BPA intravenously for 3 hours before the irradiation.
The neutron irradiation time was determined not to exceed
15 Gy-Eq to the normal brain. 20 HGMs were composedof 12 anaplastic, 4 atypical, 2 papillary, and 1 rhabdoid
meningioma and 1 sarcoma that began as an anaplasticmeningioma. All cases were recurrent after repetitive
surgeries and radiotherapies.
RESULTS AND DISCUSSION: Typical tumor
shrinkage is depicted in Fig.1.
All cases showed marked tumor shrinkage after BNCT.
2)The median survival times after BNCT and afterdiagnosis are 14.1 (95%CI: 8.6 - 40.4) and 45.7 (95%CI:32.4 - 70.7) months, respectively.
3) Major causes of treatment failure were recurrence outof field of neutron irradiation, CSF dissemination andsystemic metastasis.
HGMs are seemed to be good candidate for BNCT [3].
REFERENCES:[1] Y. Tamura et al., Case report. J Neurosurg 105 (2006)
898-903,.
[2] S. Miyatake et al., Neurosurgery 61 (2007) 82-90,
discussion 90-81,.
[3] S. Kawabata et al., J Neurosurg. In press.

Fig. 1. Representative tumor shrinkage after BNCT on
enhanced MRI.
A, B, C, D: Case 17 (anaplastic meningioma). A, C,pre-BNCT; B, D, 10 months after BNCT.
E, F, G, H: Case 14 (atypical meningioma). E, G,pre-BNCT; F, H, 6 months after BNCT.
I, J, K, L: Case 18 (anaplastic meningioma). I, K,pre-BNCT; J, L, 10 months after BNCT.
M, N, O, P: Case 20 (atypical meningioma). M, O,pre-BNCT; N, P, 4 months after BNCT.
Each case shows marked tumor volume reduction afterBNCT.

Fig. 2. Survival analysis after diagnosis and BNCT.
A, Kaplan-Meyer curve after BNCT, B, Kaplan-Meyer
curve after diagnosis. The median survival times after
BNCT and after diagnosis are 14.1 (95%CI: 8.6 - 40.4)
and 45.7 (95%CI: 32.4 - 70.7) months, respectively.

採択課題番号 24027 熱外中性子を用いた悪性脳腫瘍に対する非開頭中性子捕捉療法の 共同通常
臨床的研究
（大医大・脳外）宮武伸一、黒岩敏彦、川端信司、平松亮（京大原子炉）小野公二、増永慎一郎、鈴木 実、近藤夏子、田中浩基、櫻井良憲、丸橋 晃

CO1-2Development of Neutron Devices for Fundamental Physics

Y. Arimoto, P. Geltenbort1, S. Imajo2, Y. Iwashita3,
M. Hino4, M. Kitaguchi5, K. Mishima6, R. Sakakibara5,
Y. Seki7, H. M. Shimizu5 and T. Yoshioka7
KEK,1ILL, 2Dep. of Phys. Kyoto Univ.,3ICR Kyoto Univ.,
4KURRI, 5Dep. of Phys. Nagoya Univ.,6ICEPP, Univ. ofTokyo,7RIKEN, 8Dep. of Phys. Kyushu Univ.

mirrors in this tapered guide were made by vacuum
evaporation machine in KURRI. The intensity of neutrons from the Doppler shifter, which consists UCNs andfaster neutrons, was 49 cps with 300 kW proton beampower. It means that the improvement of neutron optics
gained about 20 times of the intensity. The result wasconsistent with a simulation within 15%.

INTRODUCTION: Neutrons can be used for studying
fundamental physics. Neutron lifetime is quite importantfor the parameter in Big Bang Nucleosynthesis. The permanent electric dipole moment of neutrons (nEDM) signals the violation of time-reversal (T) invariance. Coldneutron beam line ‘NOP’ was constructed at BL05 inMaterial Life science Facility at J-PARC for fundamental
physics experiments [1]. We are developing neutron optical devices for the experiments.

Fig. 2 Optics for Doppler shifter. (Left)
Reflectivity for mirror lattice constant of the monochromatic mirror. Green and red lines are for old andnew mirrors respectively. (Right)

BEAM DIVERGENCE MEASUREMENT: For precision measurements using neutron beam, for example,
neutron lifetime, the understanding of the phase-space
distribution of the incident beam is important. It enables
us to verify the upstream opticsof the beam line and to investigate its downstream effects.
Beam divergence measurement
system was developed. It consists movable pinhole and 2D
position sensitive detector. We
can measure the beam divergence through the pinhole withtime of flight. After the system
was tested at cold neutron
beam line CN3 in KUR, it wasFig. 1 The beam diverinstalled into the polarized
gencemeasurement
beam branch of BL05 (Fig. 1).
system on BL05.
OPTICS FOR DOPPLERSHIFTER: At the unpolarized beam branch of BL05, theDoppler shifter is working to provide Ultra Cold Neutrons (UCNs) by reflections off the rotating mirror. TheUCNs are mainly used for developments of devices forthe experiment to search nEDM. New neutron guidetubes and monochromatic mirrors were installed in order
to increase the incident slow neutrons to Doppler shifterand the extracted UCNs (Fig. 2). Supermirror guide with
m = 2 was installed after the beam bender of BL05 instead of vacuum tube. The monochromatic mirrors whichextract 3nm-neutrons for the Doppler shifter was replacedwith the new one with wider bandwidths. The mirrors
were fabricated by ion beam sputter in KURRI. The newtapered neutron guide tubes were also installed after themirrors to gather neutrons to the rotating mirror. TheNEUTRON ACCELERATOR FOR FOCUSING: For
improvement of sensitivity of nEDM experiment, thedensity of UCNs is quite important in order to reduce thesystematic errors from the uncertainty of the environment.
In the case of pulsed neutron source, when fast neutrons
are decelerated and/or slow neutrons are accelerated
properly, these neutrons can be focused on the experimental area at the same time with recovering the density.
We developed a neutron accelerator and successfully observed the focusing of UCNs at the PF2 TES beam line in
the High Flux Reactor at Institut Laue Langevin [2]. The
accelerator controlled the UCN velocity by selecting thefrequency of the RF spin flipper. The observed TOF
spectra were in good agreement with Monte Carlo simulations with focusing (Fig. 3). Now we are developing anew accelerator with wider velocity range and high power. It will be tested by using the UCNs from the Doppler
shifter at BL05.

Fig. 3 The ratio between TOF spectra with RF ON
and RF OFF. Focusing was observed.
REFERENCES:[1] K. Mishima et al., Nucl. Instr. Meth. A600(2009) 342.
[2] Y. Arimoto et al., Phys. Rev. A (2012)

採択課題番号 24053
高効率超冷中性子輸送デバイスの開発
共同通常（名大院・理）北口雅暁（九大院・理）吉岡瑞樹（理研）覚正信徳、広田克也（KEK）佐藤節夫（京大原子炉）日野正裕

CO1-3Development of a DLC Coating for Polarized UCN Guide

S. Kawasaki, Y. Masuda, K. Mastuta1, M. Mihara1, K.
Hatanaka2, R. Matsumiya2, M. Hino3 and M. Kitaguchi4
IPNS, KEK
1
Department of Physics, Osaka University
2RCNP
3
Research Reactor Institute, Kyoto University
4
Department of Physics, Nagoya University
INTRODUCTION:
Ultra-Cold Neutrons (UCN) are extremely low energy
neutrons which have a kinetic energy below a few hundred
neV. Since most material have a potential for neutron,
called Fermi potential, larger than UCN, UCN can be confined in a material bottle. Because of this characteristic,
UCN are used for various experiments such as neutron
electric dipole (nEDM) search, life time measurement,gravity experiments and so on. For nEDM search, UCN
are confined in a cell which is in a magnetic and electricfield and their spin precession frequency shift is measured.
Polarized UCN are necessary for such experiment. Since
UCN feel magnetic potential of 60 neV/T , a few T magnetic field can polarize UCN. Usually a magnetized ironfoil or a super-conducting magnet are used for a polarizer.
Polarized UCN are guided to the cell from the polarizer.
High Fermi potential and low spin depolarization are required for such guide material. Hydrogen free diamondlike carbon (DLC) is a one of the good candidate. In thisreport, Fermi potential of some DLC materials are measured by a neutron reflectometer at Kyoto University Research Reactor Institute will discussed.
EXPERIMENTS:
Four different DLC samples are prepared for this experiment. Samples are C6F6, pure Carbon, normal density Tetrahedral Amorphous Carbon (ta-C) and high density ta-C.
These samples are fabricated by ionized physical vapor
deposition on Si disk. C6F6 and pure Carbon are made byNanotec Corp.[1], ta-C samples are made by Nanofilm
Technologies [2].
DLC potential is measured by a cold neutron reflectome-ter. Fig. 1 shows a schematic drawing of the experimental setup. Incident cold neutrons of which wave lengthis 0.3 to 0.7 nm are bunched by chopper. Bunched neutrons
are reflect at the sample surface and detected by 3He counter. Time of flight between chopper and 3He detector ismeasured. Since incident neutron beam has broad velocity
distribution, detection timing is also have some width.
Slow neutrons of which transverse energy against sample
surface is lower than sample potential are total reflected at
the sample surface and are detected. Critical velocity ofreflection is measured in this measurement.

Fig. 2 : Reflectivity
RESULTS:
Reflectivity as a function of wave number is shown in
Fig. 2. Assuming sample thickness is long enough, reflectivity
iscalculated
tobe|R|2 =′ 2⁄′ 2(𝑘 − 𝑘 ) (𝑘 + 𝑘 ) , where k is incident wave number
and k’ is wave length in sample. Sample potential is determined by fitting of reflectivity with this function. Fitting
result is shown in table below. Ta-C high density has highest potential of 260 neV. This value is good enough for
guide material. We will investigate depolarization rate andmake a polarized UCN guide by DLC.
Table 1 Sample potential
Material
C6F6Pure Carbon
Ta-C normal density
Ta-C high density

Fig. 1 setup

Potential
110 neV
150 neV
230 neV
260 neV

REFERENCES:[1] Nanotec Corp. http://www.nanotec-jp.com[2] Nanofilm Technologies International
http://www.nanofilm.com.sg/index.htm

採択課題番号24077
偏極超冷中性子ガイド用 DLC 膜の評価
共同通常(KEK)川崎真介、増田康博 (阪大・理)松多健策、三原基嗣 (RCNP)畑中吉治、松宮亮平(京大・原子炉)日野正裕 (名古屋大・理)北口雅暁

CO1-4

Test of Mass Production of Neutron Supermirrors for Real Neutron Guide by
Using KUR-IBS

M. Hino, T. Oda1, N.L.Yamada2, M. Kitaguchi*,Y. Kawabata and H. Seto2
Research Reactor Institute, Kyoto University
1
Department of Nucl. Eng., Kyoto University
2
IMSS, KEK,*
Present address: KMI, Nagoya University
INTRODUCTION: Supermirror is most important
key component of neutron guide tube. The total lengthof neutron guide tube is, in general, longer than 10 m.
Ion beam sputtering (IBS) technique enables us tofabricate smooth layer structure with sharp edge andwe have succeeded in fabricating m>5 supermirrors
and very small d-spacing multilayer [1]. The
maximum substrate area at our KUR-IBS machine
was limited to 200 mm in diameter until 2011. The
maximum substrate area at JAEA-IBS machine is 500
mm in diameter and they are producing a lot ofsupermirrors for J-PARC project. In FY2011, Kyoto
University and KEK started to construct a new beamline for neutron spin echo (NSE) spectrometers atBL06 at J-PARC/MLF. The NSE spectrometers arecalled “VIN ROSE” and it has been developed by
KUR team and tested at C3-1-2-2(MINE1) beam line
at JRR-3 reactor. We designed the BL06 beam line andstarted to fabricate supermirrors for the guide tube byusing the KUR-IBS machine. The total length of theguide tube is about 29 m. We had to find out newscheme for mass production of supermirror toconstruct the neutron guide. It is important toaccumulate such experience since we have a plan fornext neutron beam facility after KUR.
EXPERIMENTS: Figure1 shows photograph of real
substrate holder for fabrication of supermirrors for theBL06 guide tube at J-PARC. The substrate holder andattachments were developed at the workshop inKURRI. The reflectivity measurements were carriedout by using two reflectometers at CN-3 in KUR andBL16 (SOFIA) at J-PARC/MLF. We checkedreflectivity of monitor mirror at the CN-3 and most ofsupermirrors were measured by the SOFIA.
RESULTS: Figure 2 shows reflectivity by typicalm=2.5, 3 supermirror on the silicon wafer. Most ofsupermirrors have been measured and performance ofthe average was high. We succeeded in fabrication oflarge scale neutron supermirror with high reflectivity

for real neutron guide. This result also contributes todevelop new monochromator for KUR-SANS [2]. Asa next step, we are going to develop two-dimensional
focusing supermirror in which shape is ellipsoid.

Fig.1 The photograph of substrate holder in whichdiameter is 460 mm and silicon wafers placed at thesubstrate holder in KUR-IBS.

Fig.2 Measured reflectivity of (a) m=2.5 and (b) m=3
NiC/Ti supermirrors deposited on the silicon wafers.

REFERENCES:[1] M.Hino, et al., Nucl.Inst.Meth. A 574(2004)292.
[2] M.Hino, et al., in this KURRI Progress
report(No. 24P9-4).

採択課題番号 24087
次期中性子ビーム科学施設のための中性子光学デバイス開発（京大・原子炉）日野正裕、川端祐司、北口雅暁（京大・工）小田達郎（高エネ機構・IMSS）山田悟史、瀬戸秀紀

共同通常