2005 年業績
Takeda R, Suzuki E, Satonaka H, Oba S, Nishimatsu H, Omata M, Fujita T, Nagai R, Hirata Y.
Blockade of endogenous cytokines mitigates neointimal formation in obese Zucker rats.
Circulation. 2005 111(11): 1398-406.
Fukuhara H, Ino Y, Kuroda T, Martuza RL, Todo T.
Triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 andsoluble B7-1 constructed by bacterial artificial chromosome-mediated system.
Cancer Res. 2005 65(23): 10663-8.
Sato F, Fukuhara H, Basilion JP.
Effects of hormone deprivation and 2-methoxyestradiol combination therapy on
hormone-dependent prostate cancer in vivo.
Neoplasia. 2005 7(9): 838-46.
Sasaki E, Kojima H, Nishimatsu H, Urano Y, Kikuchi K, Hirata Y, Nagano T.
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolatedorgans.
J Am Chem Soc. 2005 127(11): 3684-5.
Takahashi S, Suzuki M, Kume H, Matsumoto S, Okamoto N, Nishimatsu H, Tomita K, Kitamura
T.
Combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in patients withmetastatic urothelial cancer: a preliminary report.
Jpn J Clin Oncol. 2005 35(2): 79-83.
Suzuki M, Muto S, Hara K, Ozeki T, Yamada Y, Kadowaki T, Tomita K, Kameyama S, Kitamura
T.
Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might
predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients.
Int J Urol. 2005 12(2): 166-72.
Nishimatsu H, Suzuki E, Satonaka H, Takeda R, Omata M, Fujita T, Nagai R, Kitamura T, HirataY.
Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated byfluvastatin in obese Zucker rats.
Am J Physiol Heart Circ Physiol. 2005 288(4): H1770-6.
Yamashita S, Suzuki S, Nomoto T, Kondo Y, Wakazono K, Tsujino Y, Sugimura T, Shirai T,Homma Y, Ushijima T.
Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostatecancers in the aged.
Cancer Res. 2005 65(7): 2610-6.

Takei M, Homma Y; THE JAPANESE TOLTERODINE STUDY GROUP.
Long-term safety, tolerability and efficacy of extended-release tolterodine in the treatment ofoveractive bladder in Japanese patients.
Int J Urol. 2005 12(5): 456-64.
Ogushi T, Takahashi S, Takeuchi T, Urano T, Horie-Inoue K, Kumagai J, Kitamura T, Ouchi Y,
Muramatsu M, Inoue S.
Estrogen receptor-binding fragment-associated antigen 9 is a tumor-promoting and prognostic
factor for renal cell carcinoma.
Cancer Res. 2005 65(9): 3700-6.
Fujimura T, Yamada Y, Nasu M, Hamasaki K, Minowada S, Kitamura T.
Different transformation of mature teratoma in a patient with mixed germ cell tumor of the testis.
Int J Urol. 2005 12(6): 588-90.
Chen Q, Takahashi S, Zhong S, Hosoda C, Zheng HY, Ogushi T, Fujimura T, Ohta N, Tanoue A,Tsujimoto G, Kitamura T.
Function of the lower urinary tract in mice lacking alpha1d-adrenoceptor.
J Urol. 2005 174(1): 370-4.
Nyomura S, Tomita K, Kume H, Nishimatsu H, Takahashi S, Takeuchi T, Kitamura T.
A problematic complication of sex change operation.
Surgery. 2005 138(3): 543-4.
Fujimura T, Minowada S, Kishi H, Hamasaki K, Saito K, Kitamura T.
Hemiresective reconstruction of a redundant ileal conduit with severe bilateral ileal
conduit-ureteral reflux.
Int J Urol. 2005 12(10): 917-9.
Matsumoto S, Takahashi S, Goto T, Tomita K, Takeuchi T, Kitamura T.
Proteus syndrome with giant myelolipoma in the pelvis.
Int J Urol. 2005 12(11): 1005-6.
Suzuki M, Mahammed R, Hara K, Ozeki T, Yamada Y, Kadowaki T, Honda H, Yanagihara Y, ItoYM, Kameyama S, Ohta N, Hosoi T, Arai T, Sawabe M, Takeuchi T, Takahashi S, Kitamura T.
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with thePSA-progression-free survival in prostate cancer patients treated with estramustine phosphate.
Eur Urol. 2005 48(5): 752-9.
Fukuhara H, Martuza RL, Rabkin SD, Ito Y, Todo T.
Oncolytic herpes simplex virus vector g47delta in combination with androgen ablation for thetreatment of human prostate adenocarcinoma.
Clin Cancer Res. 2005 11(21): 7886-90.
Homma, Y. Yamaguchi. O. Hayashi, K. and the members of the neurogenic bladder society
committee.
An epidemiological survey of overactive bladder symptoms in Japan.
BJU Int. 2005 96: 1314-8.
Homma, Y.
Classification of nocturia in the adult and elderly patient: a review of clinical criteria and selectedliterature.
BJU Int. 2005 96(Suppl 1): 8-14.

Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S,Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, Horie S.
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells.
J Natl Cancer Inst. 2005 97(23): 1734-46.
Nagata M, Kurimoto S, Takeuchi T, Ohta N, Minowada H, Kitamura T.
Tiny nodule in the testicle: Case report of a Sertoli cell tumor.
Int J Urol. 2005 11: 61-2.
Zheng H-Y, Takasaka T, Noda K, Kanazawa A, Mori H, Kabuki T, Joh K, Oh-ishi T, Ikegaya H,Nagashima K, W.Hall W, Kitamura T, Yogo Y.
New sequece polymorphisms in the outer loops of the JC polyomavirus major capsid
protein(VP1)possibly associated with progressive multifocal leukoencephalopathy.
J Gen Virol. 2005 86: 2035-45.
Kitamura T, Nishimatsu H, Suzuki M, Mohammed R, Tomita K, Takahashi S, Takeuchi T, Ohota
N, Kameyama S.
Dual interim report of low-dose estramustine phosphate (EMP) monotherapy and very low-dose
EMP therapy combined with LH-RH agonist for previously untreated advanced prostate cancer.
J Appl Res. 2005 5(2): 331-4.
Zheng H-Y, Ikegaya H, Takasaka T, Matsushima-Ohno T, Sakurai M, Kanazawa I, Kishida S,Nagashima K, Kitamra T, Yogo Y.
Characterization of the VP1 loop mutations widespread among JC polyomavirus isolates
associated with progressive multifocal leukoencephalopathy.
Biochem Bioph Res Comm. 2005 333: 996-1002.
Zheng H-Y,Ikegaya H, Nakajima M, Sakurada K, Takasaka T, Kitamura T, Yogo Ｙ.
Two distinct genotypes (MY-x and MX) of JC virus previously identified in Hokkaido ainu.
Anthropol Sci. 2005 113: 225-31.
Mohammed R, Suzuki M, Takahashi S, Hara K, Ozeki T, Yamada Y, Kadowaki T, Yanagihara Y,Kameyama S, Ito Minagawa Y, Takeuchi T, Kitamura T.
Incidence of gastrointestinal toxicity during estramustine phosphate therapy for prostate cancer
is associated with the single-nucleotide polymorphisms in the cytochrome P450 1A1(CYP1A1)
gene.
Cancer Therapy 2005 3: 525-30.
Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S.
DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss ofheterozygosity on chromosome 9 in urothelial carcinomas.
J Urol. 2005 173: 243-6.
Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S.
DNA hypomethylation on multiple CpG islands associated with increased DNA
methyltransferase dnmt1 protein expression during multistage urothelial carcinogenesis.
J Urol. 2005 173: 1767-71.
Ikegaya H, Zheng H-Y, Saukko P J, Varesmaa-Korhonen L, Hovi T, Vesikari T, Suganami H,
Takasaka T, Sugimoto C, Ohasi Y, Kitamura T, Yogo Y.
Genetic diversity of JC virus in the saami and the finns: implications for their population history.
Am J Phys Anthropol. 2005 128: 185-93.
Kobayashi F, Kume H, Tomita K, Kitamura T.
Xanthoma of the urinary bladder.
Scand J Urol Nephrol. 2005 39(6): 527-8.