novo nordisk
innovation
summitTokyo 2012chronic inflammation
and autoimmune diseases
Programme
Tuesday 17 April

Wednesday 18 April

WelcomeSession 5

Role of innate immunity for the benefical and aberrant immunityr

08:45-08:50

Welcome, Professor Hiroshi Kiyono and Dr Anand Guatam

10:00-10:30

08:50-09:15

Introduction to Novo Nordisk Biopharmaceutical Research Unit,
Dr Per Falk, Senior Vice President, Novo Nordisk, Denmark

A novel complement regulatory factor that can suppress the development of collagen-induced arthritis,
Yoichiro Iwakura,Professor, The University of Tokyo, Japan

10:30-11:00

Emerging roles for basophils in protective and pathological immune responses,
Hajime Karasuyama, Professor, Tokyo Medical and Dental University Graduate School, Japan

Chaired by Drs T. Nakayama and E. D. Galsgaard

11:00-11:30

NKT cell subsets and their functions,
Masaru Taniguchi, Director, Research Center for Allergy and Immunology (RCAI), RIKEN

Toll-like receptor logistics by Unc93B1,
Kensuke Miyake, Professor, The University of Tokyo, Japan

11:30-13:00

Lunch

Regulation of Immune Responses by Semaphorins,
Atsushi Kumanogoh, Professor, Osaka University, Japan

Session 6

T cell regulation for the control of inflammation

10:15-10:45

CRTAM-mediated cell adhesion regulates development of pathogenic effector T cells,
Takashi Saito, Group Director, Research Center for Allergy and Immunology (RCAI), RIKEN

13:00-13:30

Genetic basis of the development and function of natural Foxp3-expressing regulatory T cells,
Shimon Sakaguchi, Professor, Kyoto University, Japan

10:45-11:00

Coffee13:30-14:00

Session 2

Receptor mediated regulation of immune responses

Fas-FasL dependent autoantibody suppression by Egr2 expressing CD4+CD25-LAG3+ T cells,
Kazuhiko Yamamoto, Professor, The University of Tokyo, Japan

Chaired by Drs A. Kumanogoh and P. V. Sivakumar

14:00-14:30

11:00-11:30

The IgM Fc receptor (FcμR) positively regulates B cell survival and antibody production,
Ji-Yang Wang, Team Leader, Research Center for Allergy and Immunology (RCAI), RIKEN

Delayed and aberrant reconstitution of immune system in Allo-HSCT,
Kouji Matsushima, Professor, The University of Tokyo, Japan

14:30-15:00

Regulation of immune response by paired receptors,
Hisashi Arase, Professor, Osaka University, Japan

Senescence-related T cell; Role in autoimmunity and malignancy,
Nagahiro Minato, Professor, Kyoto University, Japan

15:00-15:15

CoffeeSession 1
09:15-09:45
09:45-10:15

11:30-12:00
12:00-12:30

Novel aspects in the regulation of immune responses

Regulation of autoimmunity by interaction of matricellular proteins and their integrin receptors,
Toshimitsu Uede, Professor, Hokkaido University, Japan

12:30-13:00

Sensing “danger” through C-type lectin receptors,
Sho Yamasaki, Professor, Kyushu University, Japan

13:00-14:00

Lunch

Session 3

Novel targets for the control of inflammation
Chaired by Drs K. Yamamoto and W. Lei

Chaired by Drs K. Matsushima and F. Ramsdell

Chaired by Drs H. Karasuyama and C. Haase

Closing session

Chaired by Professor H. Kiyono and Dr Anand Guatam

15:15-15:45

Chaired by Professor H. Kiyono and Dr Anand Guatam
Developing viable biotech industry in Japan and Asia employing platform of personalized & frontier
Medicine: A-IMBN & SBI SBI biotech models to develop innovative immunotherapeutic products
through collaboration with Pharma and Academia,
Ken-ichi Arai, President/CEO, SBI Biotech Co., Ltd., Japan

15:45

Summit closes

14:00-14:30

HLA controls the clinical difference, overlap and conversion between Graves disease and Hashimoto
thyroiditis, Takehiko Sasazuki, President Emeritus, International medical center of Japan,
Professor Emeritus, Kyushu University, Japan

14:30-15:00

Translational research of CD26 molecules for treatment of immune-mediated disorders such as GVHD,
RA and SLE, Chikao Morimoto, Professor, The University of Tokyo, Japan

15:00-15:30

CD30 ligand is a target for a novel biological therapy against chronic inflammatory diseases,
Yashunobu Yoshikai, Professor, Kyushu University, Japan

15:30-15:55

CoffeeSession 4

Regulation of inflammatory responses at mucosa
Chaired by Drs K. Miyake and C. S. Wenander

Professor Hiroshi Kiyono,
The University of Tokyo

15:55-16:25

Regulation of gut homeostasis by innate immunity,Kiyoshi Takeda, Professor, Osaka University, Japan

Professor Ken-ichi Arai,
SBI Biotech / The University of Tokyo

16:25-16:55

Critical role of extracellular ATP and P2X7 purinoceptor for mast cell–dependent intestinal
inflammation, Hiroshi Kiyono, Professor, The University of Tokyo, JapanDr Anand Gautam,
Novo Nordisk, Denmark

16:55-17:25

Pathogenic memory Th2 cells in airway inflammation,Toshinori Nakayama, Professor, Chiba University, Japan

17:25

Day 1 closes

Organising
CommitteeVenue
The University of Tokyo
The Institute of Medical Science,
Auditorium at 1st Building,
4-6-1 Shirokanedai Minato-ku,Tokyo, JapanIMSUT & RCAST GCOE Program

Medical Science Forum Tokyo 2012 on Immunity for the Contral of Autoimmune Diseases (ICAD)

Date: April 17th-18th, 2012 Venue: Auditorium of The Institute of Medical Science, The University of Tokyo
17/Apr/2012

Speaking timeslots
8:45-9:15

Speaker

Affiliation

Hiroshi Kiyono &Dean and Professor, IMSUT &Anand Gautam

Director, Biopharmaceutical Sourcing, Novo Nordisk

Per Falk

SVP, Biopharmaceutical Res, Novo NordiskTitle

Session 1: Novel aspects in the regulation of immune responses
9:15-9:45

Masaru Taniguchi

9:45-10:15

Atsushi Kumanogoh

Free Admission (No advance registration required.)

WelcomeIntroductory remarks

Chaired by Drs. T. Nakayama and Elisabeth D. Galsgaard

Directer, Reserch center for Allergy and Immunology (RCAI),
Laboratory for Immune Regulation, RIKEN
Professor, Laboratory of Immunopathology, WPI Immunology
Frontier Research Center (IFReC), Research Institute forMicrobial Diseases, Department of Internal Medicine,Graduate

NKT cell subsets and their functions

Regulation of Immune Responses by Semaphorins.

School of Medicine, Osaka University
Group Director, Research Center for Allergy and Immunology

CRTAM-mediated cell adhesion regulates development of pathogenic effector(RCAI), Laboratory for Cell Signaling, RIKEN

T cells

10:15-10:45

Takashi Saito

10:45-11:00

Coffee BreakSession2: Receptor mediated regulation of immune responses

11:00-11:30

Ji-Yang Wang

11:30-12:00

Hisashi Arase

Chaired by Drs. A Kumanogoh and Simon Reed

Team Leader, Reserch center for Allergy and Immunology

The IgM Fc receptor (FcμR) positively regulates B cell survival and antibody(RCAI), Laboratory for Immune Diversity, RIKEN
Professor, Immunochemistry, Immunology Frontier Research

production

Center,Department of Immunochemistry, Research Institute forRegulation of immune response by paired receptors

Microbial Diseases,Osaka University
Professor, Division of Molecular Immunology, Institute forRegulation of autoimmunity by interaction of matricellular proteins and their

Genetic Medicine, Hokkaido University

integrin receptors

12:00-12:30

Toshimitsu Uede

12:30:-13:00

Sho Yamasaki

13:00-14:00

Lunch
Session3: Novel targets for the control of inflammation

14:00-14:30

Takehiko Sasazuki

14:30-15:00

Chikao Morimoto

15:00-15:30

Yashunobu Yoshikai

15:30-15:55

Coffee BreakProfessor, Division of Molecular Immunology, Medical Instituteof Bioregulation, Kyushu University

Sensing “danger” through C-type lectin receptors

Chaired by Drs. K. Yamamoto and Wang Lei

President Emeritus, International Medical Center of Japan,

HLA controls the clinical difference, overlap and conversion between Graves

Professor Emeritus, Kyushu University

disease and Hashimoto thyroiditis.

Professor, Juntendo University

Translational Research of CD26 molecules for treatment of immune-mediateddisorders such as GVHD, RA and SLE.

Professor, Research Center for Prevention of Infectious

CD30 ligand is a target for a novel biological therapy against chronic

Diseases, Medical Institute of Bioregulation, Kyushu University

inflammatory diseases

Medical Science Forum Tokyo 2012 on Immunity for the Contral of Autoimmune Diseases (ICAD)
Session4: Regulation of inflammatory responses at mucosa

Chaired by Drs. K. Miyake and Carola Schellack Wenander

Professor, Laboratory of Mucosal Immunology, WPI
15:55-16:25

Kiyoshi Takeda

Immunology Frontier Research Center (IFReC), Department ofMicrobiology and Immunology, Graduate School of Medicine,
Professor, Division of Mucosal Immunolog, Department of

16:25-16:55
16:55-17:25

Hiroshi Kiyono
Toshinori Nakayama

Microbiology and Immunology, The Institute of Medical ofscience, The University of Tokyo
Professor, Department of Immunology, Graduate School ofMedicine, Chiba University

Regulation of gut homeostasis by innate immunity
Critical role of extracellular ATP and P2X7 purinoceptor for mast cell–dependent intestinal inflammation
Pathogenic memory Th2 cells in airway inflammation

18/Apr/2012
Session5: Role of innate immunity for the beneficial and aberrant immunity
10:00-10:30

Yoichiro Iwakura

Chaired by Drs. K. Matsushima and Fred Ramsdell
A novel complement regulatory factor that can suppress the development ofProfessor, Tokyo University of Science
Professor, Department of Immune Regulation,

10:30-11:00

Hajime Karasuyama

11:00-11:30

Kensuke Miyake

11:30-13:00

science,
Lunch
Session6: T cell regulation for the control of inflammation

13:00-13:30

Shimon Sakaguchi

13:30-14:00

Kazuhiko Yamamoto

14:00-14:30

Kouji Matsushima

14:30-15:00

Nagahiro Minato

15:00-15:15

Coffee BreakClosing session

collagen-induced arthritis
Emerging roles for basophils in protective and pathological immune

Tokyo Medical and Dental University Graduate School
Professor, Division of Infectious Genetics, Department ofresponses

Microbiology and Immunology, The Institute of Medical ofToll-like receptor logistics by Unc93B1

Chaired by Drs. H.Karasuyama and Claus Haase

Professor, WPI Immunology Frontier Research Center (IFReC), Genetic basis of the development and function of natural Foxp3-expressing
Department of Experimental Immunology, Osaka University

regulatory T cells

Professor, Department of Allergy and Rheumatology, Graduate Fas-FasL dependent autoantibody suppression by Egr2 expressing
School of Medicine, The University of Tokyo
Professor, Department of Molecular Preventive Medicine,
Graduate School of Medicine, The University of Tokyo
Dean, Professor, Department of Immunology and Cell Biology,
Kyoto University Graduate School of Medicine

CD4+CD25-LAG3+ T cells
Delayed and aberrant reconstitution of immune system in Allo-HSCT
Senescence-related T cell; Role in Autoimmunity and Malignancy

Chaired by Prof Hiroshi Kiyono and Anand Gautam
Developing viable Biotech Industry in Japan and Asia employing Platform of15:15-15:45

Kenichi Arai

President/CEO, SBI Biotech Co. LTd.

Personalized & Frontier Medicine: A-IMBN & SBI SBI Biotech Models todevelop innovative immunotherapeutic Products through collaboration withPharma & Academia

Contact: Division of Mucosal Immunolog, The Institute of Medical of science, The University of Tokyo Email: yonehara@ims.u-tokyo.ac.jp TEL:03-5449-5271