Monday 13th March 2017
15:00 – 17:00
Registration, poster display, and travel award collection
17:00 – 19:00
Keynote lectures (chaired by Yousuke Takahama)
Jonathan Sprent (Garvan Institute)
The Thymus: From the Greeks to Miller
Shigeo Koyasu (Riken)
From T cell to ILC
Nagahiro Minato (Kyoto University)
Aging of Immunity and Immunity in Aging
19:00 – 20:00
Welcome drink

Tuesday 14th March 20178:45 – 10:25
Thymus organogenesis (chaired by Nancy Manley and Yoko Hamazaki)
Nancy Manley (University of Georgia)
A molecular mechanism controlling fetal TEC differentiation
Clare Blackburn (University of Edinburgh)
A mechanistic framework for early TEC differentiation
Ellen Richie (MD Anderson Cancer Center)
Molecular regulators and targets of Tbx1 in fetal TEC
10 min - Noam Kadouri (Weizmann Institute of Science)
HDAC1/2 regulate Foxn1 expression and thymus organogenesis
10 min - Brian Larsen (NCI NIH)
The identification of regulatory elements critical for the expression of Foxn1 in thymic epithelial
cells
10 min - Carlos Mayer (University of Basel)
Cracking a 200-piece puzzle: Decryption of TEC development – one cell at a time
10 min - Shir Nevo (Weizmann Institute of Science)
Decomposition of the thymic stroma by massively parallel single cell transcriptome analysis
Coffee break
10:55 – 12:15
Thymic epithelial cells (chaired by Graham Anderson and Izumi Ohigashi)Georg Hollander (University of Basel and University of Oxford)
Polycomb repressive complex 2 is essential for regular thymic epithelial cell development andfunction
Ann Chidgey (Monash University)
Defining the requirements for postnatal thymic epithelial progenitor cell self-renewal anddifferentiation
10 min - Julie Sheridan (WEHI)
Intrathymic mesenchymal progenitor cells lacking epithelial differentiation capacity form
thymospheres.
10 min – Sayumi Fujimori (Okazaki Institute for Integrative Bioscience)
Activation of Wnt/β-catenin signaling in thymic epithelial progenitors
10 min - Stephanie de Barros (UCLA)VEGF regulates neonatal thymic epithelium indirectly through NRP1 signaling on thymic
mesenchyme
10 min - Matous Voboril (Institute of Molecular Genetics, Prague)Toll-like receptor signaling in thymic epithelial cells
Break (lunch)13:45 – 16:15
Thymic medulla (chaired by Jakub Abramson and Manami Itoi)
Graham Anderson (University of Birmingham)
Regulation of the thymic medulla by the type 2 IL4 receptor
Part Peterson (University of Tartu)
APECED autoimmunome
Jakub Abramson (Weizmann Institute of Science)
Aire hijacks DNA damage machinery to induce promiscuous gene expression in the thymus
Matthieu Giraud (Paris Descartes University)
3'UTR shortening of Aire-sensitive genes contributes to their induced stable expression in
the thymic epithelium
Hiroyuki Takaba (University of Tokyo)
T cell selection mediated by Fezf2 in thymus
Ludger Klein (Ludwig-Maximilians University)
Clonal deletion vs clonal diversion: Shaping of the polyclonal CD4 T cell repertoire by a CNS
auto-antigen
10 min - Taishin Akiyama (University of Tokyo)
RANK and CD40 signaling promote development of mature conventional dendritic cells in thethymus10 min - Yoko Hamazaki (Kyoto University)
Neutrophil recruitment and activation by Hassall’s corpuscles
10 min - Jessica Lancaster (University of Texas at Austin)
2-photon imaging reveals distinct contributions of dendritic cells versus medullary thymic
epithelial cells to central tolerance induction in response to tissue restricted antigen variants
Coffee break
16:40 – 19:00
Lineage commitment (chaired by David Wiest and Ichiro Taniuchi)
Hans-Reimer Rodewald (DKFZ)
Deciphering hematopoietic pathways emerging from stem cells in vivo
Ellen Rothenberg (California Institute of Technology)
Transcriptional and epigenetic control of lineage commitment via Bcl11b activation in early T
cells
JC Zuniga-Pflucker (University of Toronto)
RBPJ-Inducible in vivo system for addressing the Notch signaling requirements throughout T-celldevelopment
Freddy Radtke (EPFL)
Tcf7 - Lineage repressor and essential mediator of Notch-induced T-ALL
Ichiro Taniuchi (IMS Riken)
Evolutionarily conserved splice variant of Cbfb confers homing capacity to pre-thymic
progenitors

10 min - Masaki Miyazaki (Kyoto University)
Innate versus adaptive lymphoid cell fate is controlled by the E-Id protein axis
10 min - Chintan Parekh (UCLA)BCL11B is a key regulator of the initial stages of human thymopoiesis
10 min - Hiroyuki Hosokawa (California Institute of Technology)
PU.1 regulates gene expression in early T cells via redirection of transcription factor ensembles
10 min - Tomokatsu Ikawa (IMS Riken)
A critical role of non-canonical PRC1 for specification to lymphoid lineage

Wednesday 15th March 20178:45 – 10:05
Thymocyte development (chaired by Katia Georgopoulos and Yasutoshi Agata)
Cornelis Murre (UCSD)
Nuclear architecture and thymocyte development
Katia Georgopoulos (Harvard Medical School)
Super-enhancer reprogramming drives a B cell-epithelial transition and high-risk leukemia
10 min - Matthew McCormack (WEHI)
Lmo2-induced repression of IL-7 receptor impedes cellular competition to promote Notch
mutations during T-cell leukemogenesis
10 min - Katsuto Hozumi (Tokai University)
Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient
pro-B cells
10 min - Chia-Jui Ku (University of Michigan)
A Gata3 transcriptional switch regulates Tcrb allelic exclusion
10 min - Yasutoshi Agata (Shiga University of Medical Science)
E2A and CBP/p300 regulate chromosome dynamics of the TCRb locus
Coffee break
10:35 – 11:55
Thymocyte diversity (chaired by JC Zuniga-Pflucker and Tomokatsu Ikawa)David Wiest (Fox Chase Cancer Center)
A genome wide view of γδ lineage commitment
Dale Godfrey (University of Melbourne)
Development and diversity of MR1-restricted alpha beta and gamma delta T cells
10 min - Michele Anderson (University of Toronto)
Delineation of two distinct subsets of IL-17 producing gamma-delta T cells by developmental
dependence on HEB and expression of CD73
10 min - Howard Xue (University of Iowa)
All is useful: defining the requirements for Tcf1 short isoforms in T cell development andresponses
10 min - Christelle Harly (NCI NIH)
T cell factor-1 controls cellular growth and proliferation at β-selection
10 min - Takehito Sato (Tokai University)
Metabolic change plays a role in CD4/8 T cell fate decision?
Group photo
Break (lunch)13:40 – 15:30
Thymocyte selection (chaired by Harumi Suzuki and Motoko Kimura)
Alfred Singer (NCI NIH)
MHC-restricted TCR recognition is the result of CDR3 sequence constraints imposed during
thymic selection
Nicholas Gascoigne (National University of Singapore)
Themis and the control of T cell receptor signaling strength during differentiation
Yousuke Takahama (University of Tokushima)cTEC-dependent positive selection of CD8 T cells
10 min - Rushika Wirasinha (Monash University)
TCR signal strength at the CCR7- stage of thymocyte development partitions αβ T cells towards
the intestine or spleen
10 min - Andreas Krueger (Hannover Medical School and Goethe University Frankfurt)
The role of microRNA miR-181a/b-1 in thymic selection
10 min - Tadashi Yokosuka (Tokyo Medical University)
Microclusters as a signaling unit for T cell receptor endocytosis
10 min - Dominic Golec (University of Alberta)
Agonist selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes requires RasGRP1
10 min - Shawn Fahl (Fox Chase Cancer Center)
Regulation of γδ T cell development and function by Tcf7 is linked to altered TCR responsiveness
Coffee break
16:00 – 18:30
Thymocyte differentiation (chaired by Stephen Jameson and Takehito Sato)
Remy Bosselut (NCI NIH)
Control of CD4+ T cell effector differentiation by the transcription factors Thpok and LRF
Lauren Ehlrich (University of Texas at Austin)
CCR7 modulates the generation of thymic regulatory T cells by altering the composition of thethymic dendritic cell compartment
Kris Hogquist (University of Minnesota)
CCR7 defines a multipotent progenitor for iNKT cells in thymus and periphery
Roland Scollay (Independent)
Cellular dynamics in the thymic medulla - many questions remain
10 min - Satoshi Kojo (IMS Riken)
Helper-lineage dominant activity of maturation enhancer in the Cd4 gene is controlled by asilencer-independent and Runx-dependent mechanism
10 min - Miho Shinzawa (NCI NIH)
Impact of ‘coreceptor competition’ on thymic selection
10 min - Emilie Cosway (University of Birmingham)
Lymphotoxin β receptor signals on thymic stroma regulate the intrathymic dendritic cell pool for
central tolerance

10 min - Akira Takeda (University of Turku)
Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of
sphingosine-1-phosphate receptor expression
10 min - Tomoya Narita (University of Tokyo)
The Skint gene family is specialized in regulating Vγ5Vδ1 T cells
Adrian Hayday (Francis Crick Institute and King’s College London)
Butyrophilins and their relatives are critical regulators of gamma delta cell biology in mice andman
18:30 – 19:30
Poster presentation I + drink
19:30 – 21:30
Mixer

Thursday 16th March 20178:45 – 10:15
T cell memory (chaired by Toshinori Nakayama and Masakatsu Yamashita)Toshinori Nakayama (Chiba University)
Memory type pathogenic Th2 (Tpath2) cells in airway inflammation
J Victor Garcia (University of North Carolina at Chapel Hill)
In vivo analysis of human tissue-resident memory T cells
10 min - Takeshi Yamada (Ehime University)
Histone H3K27 demethylase negatively controls memory formation of Ag-stimulated CD8+ T cells
10 min - Thomas Ciucci (NCI NIH)
Memory fate is imprinted in CD4+ T-cells by a Thpok-dependent transcriptional program
10 min - Shaun McColl (University of Adelaide)
CCR2 is critical for memory CD8+ T cell generation following influenza A virus infection
10 min - Ryoji Yagi (Chiba University)
Role of Th2-associated transcription factors in Th9 cell differentiation
10 min - Stephen Turner (Monash University)
Enhancer commissioning and decommissioning regulates lineage-specific transcriptional
activation during virus-specific CD8+ T cell differentiation
Coffee break
10:40 – 12:00
T cell function (chaired by Masato Kubo and Ryoji Yagi)
Masato Kubo (IMS Riken)
Role of T follicular helper (Tfh) and Th1 cells in anti-viral immunity
10 min - Taras Kreslavsky (IMP Vienna)
Control of germinal center response by the transcription factor Bhlhe40
10 min - Masatsugu Oh-hora (Kyushu University)
Loss of store-operated Ca2+ entry in T cells causes autoimmunity through follicular helper T cell
activation
10 min - Tomoyoshi Yamano (Ludwig-Maximilians University)
Deciphering the lineage identity of Aire expressing antigen presenting cells in peripheral
lymphoid organs
10 min - Konstantina Alexandropoulos (Icahn School of Medicine at Mount Sinai)
Thymus-resident SIRPα-CD8α+ dendritic cells comprise a heterogeneous population consisting ofsubsets with distinct antigen uptake and cross-presenting properties
10 min - Ayelet Avin (Weizmann Institute of Science)
Quantitative analysis of protein-protein interactions and post-translational modifications in
mTECs and other rare populations
10 min - Erin Baker (University of Georgia)
Whole organ phenotypic analysis of cellular mechanisms that can regulate neonatal thymusorganization using CLARITY

Break (lunch; domestic KTCC council meeting)
13:30 – 15:40
Innate cells (chaired by Cynthia Guidos and Kazuyo Moro)
Cynthia Guidos (University of Toronto)
Differential impact of Notch signalling on development of innate T cells in neonatal vs adultthymusWilfred Ellmeier (Medical University of Vienna)
Molecular control of innate-like T cell development
Koichi Ikuta (Kyoto University)
Regulation of IL-7 receptor expression by a proximal enhancer
10 min - Sumedha Roy (Duke University Medical Center)
The innate-like T cell developmental program is actively suppressed by ID proteins prior to
TCR-mediated selection
10 min - Kazuya Iwabuchi (Kitasato University)
A role of NKT cell - adipocyte interaction in the development of obesity
10 min - Hiroshi Watarai (University of Tokyo)
Differential role of CD1d in the development and functional acquisition of invariant natural killer
T cell subtypes
10 min - Satoshi Koga (IMS Riken)
Peripheral tissue-mediated microenvironmental factors optimize terminal differentiation of ILC2
10 min - Yasutaka Motomura (IMS Riken)
Role of group 2 innate lymphoid cells in IL-4-mediated immune responses
10 min - Shinichiro Sawa (Hokkaido University)
Mesenchymal organizer cell-derived RANKL induces terminal differentiation of LTi cell in thelymph node anlagen
10 min - Akihisa Oda (Tokyo University of Science)
The cell components of perifollicular hematopoietic niche in the spleen
15:40 – 17:00
Poster presentation II + coffee
17:00 – 18:30
T cell regulation (chaired by Daniel Gray and Shohei Hori)
Daniel Gray (WEHI)
Molecular control of FOXP3+ regulatory T cell survival and death during chronic viral infection
10 min - Jung-Hyun Park (NCI NIH)
IL-7Ra is a negative regulator of IL-2 signaling in Foxp3+ Treg and CD4 effector T cells
10 min - Joost van Meerwijk (Centre de Physiopathologie de Toulouse Purpan)
Recirculation of peripheral regulatory T cells back to the thymus

10 min - Xuguang Tai (NCI NIH)
Differentiation of regulatory and helper T cells are both arrested in the thymus of mice expressing
a monoclonal TCR repertoire
10 min - Amy Palin (NICHD NIH)
Increased generation of regulatory T cells in the presence of reduced T cell receptor signaling
capacity correlates with a reduction in positive selection of thymocytes
10 min - Wanjun Chen (NIDCR NIH)
SUMOylation in Foxp3 regulates Treg function
10 min - Mariko Kashiwagi (Harvard Medical School)
Direct control of regulatory T cells by keratinocytes
10 min - Ei Wakamatsu (Tokyo University of Science)
The responsiveness to TCR stimulation of Treg subsets influences the dependency of their
proliferation on CD28
Short break
18:40 – 19:20
Special lecture (chaired by Hiroshi Kawamoto)Shimon Sakaguchi (Osaka University)
Transcriptional and epigenetic basis of regulatory T cell development

Friday 17th March 20178:45 – 10:25
Aging (chaired by Janko Nikolich-Zugich and Ryo Goitsuka)
Janko Nikolich-Zugich (University of Arizona)
Changes in secondary lymphoid organs with aging
Li Wu (Tsinghua University)
Wnt5a in DC differentiation and aging
10 min - Dong-Ming Su (University of North Texas Health Science Center)
Central tolerance establishment under thymic involution
10 min - Aiko Kato (Kyoto University)
Reduced thymic output and subsequent homeostatic proliferation induce phenotypic changes andenhance proinflammatory traits in naïve CD8 T cells
10 min - Mladen Jergovi (University of Arizona)
Impaired priming of cytotoxic T cells due to cell-extrinsic factors underlies the age-related
vulnerability to infection with intracellular pathogens
10 min - Martti Laan (Tartu University)
Pregnancy-induced thymic involution is associated with suppression of chemokines essential for
T-lymphoid progenitor homing
10 min - Olov Ekwall (University of Gothenburg)
Long term effects of early thymectomy: a population-based cohort study
10 min - Antoine Toubert (Universite Paris Diderot)
Deciphering the human thymic function in healthy adults: the Milieu Intérieur study
Coffee break
10:50 – 12:30
Disease (chaired by Hisashi Arase and Kenji Kabashima)
Hisashi Arase (Osaka University)
MHC class II-associated neo-self antigens are targets for autoantibodies in autoimmune diseases
Mitsuru Matsumoto (Tokushima University)
Paradoxical development of polymyositis-like autoimmunity through augmented expression ofAIRE
10 min - Sachiko Ono (Kyoto University)
Functional redundancy of dendritic cell subsets and independency of Ag cross-presentation
pathway for T cell activation in the elicitation phase of a murine contact hypersensitivity
10 min - Masamoto Kanno (Hiroshima University)
Identification of DAMPs molecules in mothers’ milk; a cohort study on atopic dermatitis inbreastfed infants
10 min - Yujin Nakagawa (Kyoto University)
Lymph node stromal cell-mediated deletional tolerance controls the development of GVHD-likeskin lesion in involucrin-mOVA mice

10 min - Ulus Atasoy (University of Missouri)
Control of IL-2 homeostasis and CD4 T cell differentiation by HuR in allergic airway inflammation
10 min - Koji Hayashizaki (Chiba University)
Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation
10 min - Junichi Kikuta (Osaka University)
Vascular permeability in bone marrow microenvironment analyzed by intravital two-photon
microscopy
Break (lunch)
14:00 – 16:30
Reconstruction and therapy (chaired by Georg Hollander and Richard Boyd)
Thomas Boehm (Max Planck Institute of Immunobiology and Epigenetics)
Reconstruction of ancient thymopoietic environments
Marcel van den Brink (Memorial Sloan Kettering Cancer Center)
Neuroendocrine modulation of thymic recovery after injuries
Naomi Taylor (Institute de Genetique Moleculaire de Montpellier)Fueling T cell differentiation
Richard Boyd (Melbourne)Sports CAR's: "Off-the-shelf" CAR-T cells with multiple anti-cancer specificities - next
generation immunotherapies
Hiroshi Kawamoto (Kyoto University)
Regeneration of CD8αβ type T cells with potent tumor antigen-specific cytotoxic activity from T
cell-derived iPSCs
10 min - Immo Prinz (Hannover Medical School)
Human γδ T cells are quickly reconstituted after stem cell transplantation and show adaptive
clonal expansion in response to viral infection
10 min - Michael Hun (Monash University)
Native thymic extracellular matrix improves in vivo thymic organoid T cell output, anddrives in vitro thymic epithelial cell differentiation
10 min - Charles Earnshaw (University of Liverpool)
CD8+ T cell response to HPV vaccine antigen in nasopharynx-associated lymphoid tissue
provides insight into potential protection against oropharyngeal cancer
10 min - Naoko Nakano (Tokyo University of Science)
Differential activation of T cells in tumor microenvironment
10 min - Muhammad Baghdadi (Hokkaido University)
IL34-modified tumor-associated macrophages suppress anti-tumor T cell response at the local
tumor microenvironment
Closing remarks
18:00 – 22:00
Farewell party @ Ace cafe

Posters
P1. Jennifer Cowan (NCI NIH)
Discovering novel transcriptional controllers of thymic epithelial cells
P2. Song Baik (University of Birmingham)
Identifying mTEC progenitors and understanding mTEC developmental pathways
P3. Izumi Ohigashi (University of Tokushima)
A human Psmb11 polymorphism affects molecular processing of thymoproteasome and thymic
production of CD8 T cells
P4. Takeshi Nitta (University of Tokyo)
Thymoproteasome mutations impact CD8 T cell development
P5. Anna Chuprin (Weizmann Institute of Science)
Aire hijacks DNA damage machinery to induce promiscuous gene expression in the thymus
P6. Miho Sekai (Kyoto University)
Thymopoiesis regulates clonogenic activity of thymic epithelial cells
P7. Yael Goldfarb (Weizmann Institute of Science)
Dominant negative breakdown of central tolerance by AIRE ΔPHD2
P8. Jianwei Wang (Kyoto University)
Identification and analysis of medullary thymic epithelial cells constituting Hassall’s corpuscles in
the murine thymus
P9. Beth Lucas (University of Birmingham)
Lymphotoxin β receptor controls T cell progenitor entry to the thymus
P10. Roland Ruscher (University of Minnesota)
CD8αα IEL arise from two major thymic precursor subsets
P11. Ivan Dzhagalov (National Yang-Ming University)
The importance of heparan sulfate for the development of the thymus
P12. David Davis (Australian National University)
Novel role for heparan sulfate in intrathymic T cell development
P13. Shlomit Reich-Zeliger (Weizmann Institute of Science)
Multiparameter mass cytometry of T cell development and selection
P14. Takeshi Ito (Kyoto University)
Bone marrow endothelial cells cross-present blood-borne antigens to CD8+ T cells.
P15. Takahiro Hara (Kyoto University)
Identification of bone marrow IL-7 niche critical for B lymphopoiesis
P16. Ronay Cetin (Sabanci University)
Identification of transcription factor binding sites in the IL-7R gene enhancer by CRISPR/Cas9
genome editing
P17. Guangwei Cui (Kyoto University)
Competitive signaling between STAT5 and PI3K of IL-7R modulates T cell development andhomeostasis in vivo
P18. Joo-Young Park (NCI NIH)
The IL-4 receptor/STAT6 axis controls IL-4-producing NKT2 cell lineage choice in the thymus

P19. Elise R Breed (University of Minnesota)
CD301b+ SIRPα+ dendritic cells are enriched in the thymic medulla
P20. Tyng-An Zhou (National Yang-Ming University)
Characterization of mouse thymic resident myeloid populations
P21. Masashi Watanabe (NCI NIH)
Unique roles of TECs, DCs and B cells in Treg repertoire formation
P22. Maile Romero-Wolf (California Institute of Technology)
Bcl11b-dependent T cell gene regulatory network at commitment
P23. Jyoti Sen (NIA NIH)
TCF1 and beta-catenin regulate generation of innate cells in the thymus
P24. Tomonori Hosoya (University of Michigan)
Gata3 gene regulation in the T cell transcriptional network during early T cell development
P25. Li-Qi Li (NICHD NIH)
Investigating the role of Ldb1 transcription complexes in T cell acute lymphoblastic leukemia
P26. Marco Craveiro (NCI NIH)
The same TCRβ chain can pair with different TCRα chains to form either MHC-independent or
MHC-restricted TCRs
P27. Ryunosuke Muro (National Center for Global Health and Medicine)
Syk-mediated TCR signaling is required for γδ T cell development and acquisition ofproinflammatory potential
P28. Leston Araujo (Universite Paris Diderot)
Deciphering the human thymic function in healthy adults: the Milieu Intérieur study
P29. Helena Nunes-Cabaço (Universidade de Lisboa)
IL-4 induces coreceptor reversal in CD4-committed human thymocytes
P30. Eri Ishikawa (Kyushu University)
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP1
P31. Kieran James (University of Birmingham)
Lymphotoxin β receptor signaling controls thymic T cell egress via regulation of thymic stroma
P32. Jun Wang (Soochow University)
Roles of ZBTB24 in T cells
P33. Yasuyo Harada (Tokyo University of Science)Role of follicular helper TFH in TH2 mediated anaphylaxis
P34. Yusuke Endo (Chiba University)
Elucidation of the role of fatty acid metabolism in Th17 cell differentiation under obese conditions
P35. Yun Guo (Hiroshima University)
A role of the ubiquitin-modifying enzyme A20 in regulatory T cells
P36. Eszter Bakos (Weizmann Institute of Science)
CCR2 regulates the immune response by modulating the conversion and function of effector versus
regulatory T cells
P37. Yumie Tokuanga (Universidade de Lisboa)
Differentiation of FOXP3+ regulatory T cells in the human thymus: unbiased approaches
circumventing sequential-gating strategy

P38. Hiroki Satooka (Shiga University of Medical Science)
Impaired CD8+ regulatory T cell homeostasis and self-tolerance in moesin-deficient miceP39. Jasmine Li (Monash University)
Understanding the importance of demethylating H3K27me3 as an early molecular change in CD8+
T cell differentiation
P40. Nobuko Tokuda (Yamaguchi University)
Localization and function of FABP7 in T cell area fibroblastic reticular cells
P41. Yurina Miyajima (IMS Riken)
Function of BMP2 and BMP7 produced by ILC2 in the adipose tissue
P42. Takato Kobayashi (IMS Riken)
Characterization of group 2 innate lymphoid cells in glandular tissue
P43. Hui Jin (Osaka University)
TSH receptor/MHC class II neo-self complexes are involved in Graves’ disease as autoantibody
targets
P44. Davoud Jazayeri (University of Queensland)
Preferential migration of E7 specific activated CD8 T cells to E7 transgenic skin grafts
P45. Yuki Morimoto (Chiba University)
Tissue fibrosis in eosinophilic chronic rhinosinusitis
P46. Daisuke Nagakubo (Shiga University of Medical Science)
CCL28 regulates CD4+ T cell recruitment to the nasal mucosa in a mouse model of allergic rhinitis
P47. Manju Jain (Central University of Punjab)
Thymus is a target organ in visceral Leishmaniasis: A new piece in the immunology ofLeishmaniasis
P48. Hyeongjin Na (Seoul National University)
Critical role of RORγt on Th2 cell responses in allergic airway inflammation
P49. Kosuke Miyauchi (IMS Riken)
Intrinsic role of lung recruitment of Th1 cells for mucosal IgA production in influenza virus infection
P50. Angela Wahl (University of North Carolina at Chapel Hill)
Two new in vivo model systems to directly examine human gut microbiota’s role in human T cell
development and immunity
P51. Marie Pouzolles (Université Montpellier)
Intrathymic hematopoietic stem cell transplantation supports the rapid differentiation of regulatory
T cells in immunodeficient miceP52. Heather Thompson (University of Arizona)Sex steroid ablation restores the thymus of aged animals but fails to improve naïve T cell numbers
and function in peripheral lymph nodes
P53. Christina Lundqvist (University of Gothenburg)
Deep sequencing of the T and B cell receptor repertoire shows increased T cell receptor
oligoclonality in patients after early thymectomy
P54. Yong Fan (Allegheny Health Network)
Generating injectable thymus organoids with self-assembling hydrogel to restore adaptive
immune function

P55. Edward Chen (University of Toronto)
Controlled initiation of T-cell development reveals a temporal regulation in the generation of
specific γδ T-cell receptor repertoires and functional subsets
P56. Takuya Maeda (Kyoto University)
iPSCs transduced with WT1-TCR gene give rise to potent CTLs with antigen specific cytotoxic
activity comparable to those from T-iPSCs
P57. Xiubo Fan (Singapore General Hospital)
Combination of CXCL5 and anti-CCL24 antibody substitute mesenchymal stromal cells therapy ingraft versus host disease