The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3)“Immune System Development, Deviation, and Regulation”
Thursday 13 February and Friday 14 February 2014
Fujii Memorial Hall, Kuramoto Campus, University of Tokushima
Guest speakers:
Shizuo Akira (Osaka University)
Shohei Hori (Riken Center for Integrative Medical Science, Yokohama)
Hajime Karasuyama (Tokyo Medical and Dental University)
Shigeo Koyasu (Riken Center for Integrative Medical Science, Yokohama)Vijay Kuchroo (Harvard Medical School, Boston)Alfred Singer (National Institutes of Health, Bethesda)
Dinah Singer (National Institutes of Health, Bethesda)
Masakatsu Yamashita (Ehime University)
Akihiko Yoshimura (Keio University, Tokyo)
Host organizers:
Naozumi Ishimaru (Graduate School of Oral Sciences)
Taku Okazaki (Institute for Genome Research)
Mitsuru Matsumoto (Institute for Enzyme Research)
Yoshiyuki Minegishi (Institute for Genome Research)
Tohru Sakai (Graduate School of Nutrition and Bioscience)
Yousuke Takahama (Institute for Genome Research)
Tetsuo Yamazaki (Graduate School of Pharmaceutical Sciences)
Koji Yasutomo (Graduate School of Medical Sciences)
Contact:
Immunology Program at the University of Tokushima (iPUT)
3-18-15 Kuramoto, Tokushima 770-8503, Japan
Phone: +81-88-633-9452E-mail: takahama@genome.tokushima-u.ac.jp
Sponsored by:Strategic Project for Innovative Research “iPUT”, University of Tokushima
Co-sponsored by:
MEXT Scientific Research on Analysis and Synthesis of Multidimentional Immune Organ
NetworkJoint Usage/Research Center, Institute for Enzyme Research, University of Tokushima

Thursday 13 February
13:00 – 13:10

Opening remarks by Yousuke Takahama

Session 1: Immune system development
Chaired by Y Takahama & M Matsumoto
13:10 – 13:45

Alfred Singer (Bethesda)
Basis for CD4 T cell fate determination in the thymus

13:45 – 14:05

Kensuke Takada (Tokushima)
What is the positive selection for?

14:05 – 14:25

Mitsuru Matsumoto (Tokushima)
Aire-dependent organization ofestablishment of self-tolerance

14:25 – 15:00

thymicmicroenvironment

fortheShigeo Koyasu (Yokohama)Allergic inflammation and natural helper cell, a member of ILC2s

Group photo & coffee
Session 2: Immune mechanisms
Chaired by K Yasutomo & T Yamazaki
15:30 – 16:05

Shizuo Akira (Osaka)
The role of Regnase-1 in the control of immune response

16:05 – 16:40

Shohei Hori (Yokohama)
Genetic control of regulatory T cell homeostasis in non-lymphoid tissues

16:40 – 17:05

Masakatsu Yamashita (Ehime)
The role of Menin in CD4 T cell senescence and homeostasis

17:05 – 17:40

Dinah Singer (Bethesda)
The two faces of BRD4

Session 3: Short talks I
Chaired by I Okazaki & C Ishifune
17:40 – 17:50

Izumi Ohigashi (Tokushima)
Development and developmental potential of β5t-expressing thymic
epithelial cells

17:50 – 18:00

Motoko Kimura (Chiba)
Strong TCR signaling prolongs lineage uncertainty but then accelerates
lineage commitment during MHC-I specific positive selection in the thymus

18:00 – 18:10Hitoshi Nishijima (Tokushima)
Ectopic Aire expression in thymic cortex reveals inherent properties of Aireas a stromal factor within medullary microenvironment

18:10 – 18:20

Chieko Ishifune (Tokushima)
Requirement of Notch signaling for the development of intestinal
intraepithelial T cells

18:20 – 18:30

Kyoko Masuda (Kyoto)
Regeneration of antigen specific T cells using the iPS cell technology:
A novel strategy of cancer immunotherapy

Dinner at Isuien, hosted by Susumu Kagawa, President, University of Tokushima
MC by N Ishimaru & R Arakaki

Friday 14 February 2014Session 4: Immune system deviation
Chaired by Y Minegishi & N Ishimaru
9:30 – 10:05

Hajime Karasuyama (Tokyo)
Emerging roles for basophils in health and disease

10:05 – 10:25

Yoshiyuki Minegishi (Tokushima)
Molecular pathogenesis of hyper IgE syndrome

10:25 – 10:45

Naozumi Ishimaru (Tokushima)Controlling autoimmunity by adipose tissue-associated macrophages

CoffeeSession 5: Short talks II
Chaired by Y Kudo & Y Nishikawa
11:00 – 11:10

Yohko Kitagawa (Osaka)
Divergent roles of the genome organizer Satb1 in the development of thymic
and peripheral regulatory T cells

11:10 – 11:20

Takaaki Tsunematsu (Tokushima)
The novel function of geminin via the escape from ubiquitin
proteasome-mediated proteolysis in DNA replication and cell differentiation

11:20 – 11:30

Takeshi Wada (Tokushima)Enhanced mast cell activation in mouse model of hyper-IgE syndrome
11:30 – 11:40

Daisuke Sugiura (Tokushima)
Molecular analyses of an inhibitory co-receptor, LAG-3

11:40 – 11:50

Saradee Warit (Pathumthani)
Candidate protein markers to determine infected Tuberculosis stages inhumans

11:50 – 12:00

Beata Shiratori (Sendai)
Attempt to distinguish between LTBI and active TB by latency-related
antigens and biomarkers

Lunch with students, managed by K Takada & I Ohigashi

Session 6: Immune system regulation
Chaired by T Okazaki & T Sakai
14:00 – 14:35

Vijay Kuchroo (Boston)Transcriptional network controlling the development of Tregs and Th17
cells

14:35 – 15:10

Akihiko Yoshimura (Tokyo)
Regulation of Treg development by TGF-beta and NR4a

15:10 – 15:30

Taku Okazaki (Tokushima)
Regulation of autoimmunity by immuno-inhibitory receptors

Closing remarks by Sumihare Noji, Director of Research, University of Tokushima