<< GE00022 4-METHYL-2-PENTANONE >>

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Safety Data Sheet
1. Chemical product and company identification
Product name: 4-METHYL-2-PENTANONE

Company information
Name of manufacturer
Address
Name of section
Telephone number
Facsimile number
Mail address
Reference No： KANTO CHEMICAL CO., INC.
： 2-1, Nihonbashi, Muromachi 2-Chome, Chuo-Ku, Tokyo, 103-0022, Japan： Electronic materials division technical department： +81-3-6214-1080： +81-3-3241-1043： el-info@kanto.co.jp: GE00022 1.3Recommended uses andrestrictions: Electronic chemicals

2. Hazards identification
GHS classification
Physical hazards

Flammable liquids

Category 2

Health hazards

Acute toxicity(inhalation:vapors)

Category 3

Serious eye damage/eyeirritation

Category 2B

Carcinogenicity

Category 1BSpecific target organ toxicity(single exposure)

Category 3 (narcosis)

Specific target organ toxicity(single exposure)

Category 3 (respiratory tract irritation.)

Specific target organ toxicity(repeated exposure)

Category 1 (central nervous system)

Hazardpictograms

Signal word:DangerHazard statements:

Highly flammable liquid and vapor
Causes eye irritation
Toxic if inhaled
May cause respiratory irritation
May cause drowsiness or dizziness
May cause cancer
Causes damage to organs (central nervous system) through prolonged
or repeated exposure:

Do not handle until all safety precautions have been read andunderstood.
Keep away from heat, hot surfaces, sparks, open flames and otherignition sources. No smoking.

Precautionary statements
Prevention

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Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use only non-sparking tools.
Take action to prevent static discharges.
Do not breathe mist/vapors.
Wash hands, forearms and face thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/faceprotection.
Response:

IF ON SKIN (or hair): Take off immediately all contaminatedclothing. Rinse skin with water .
IF INHALED: Remove person to fresh air and keep comfortable forbreathing.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
If eye irritation persists: Get medical advice/attention.

Storage:Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.

Disposal:

Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3. Composition/information on ingredients
Distinction of substance ormixture:

Substance

Synonyms:

Methyl iso-butyl ketone, Methyl isobutyl ketone, MIBK

Chemical name4-Methyl-2-pentanone

Concentration (%)
min. 99.5

Formula(CH3)2CHCH2CO
CH3

TSCA
ListedEC-No.
203-550-1

CAS RN
108-10-1

4. First aid measures
First aid measures
First-aid measures afterinhalation:Remove victim to fresh air and keep at rest in a position
comfortable for breathing. Immediately get medical treatment.

First-aid measures after skincontact:

Wash the affected areas under running water.

First-aid measures after eye
contact:

Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

First-aid measures afteringestion:

The chemical is volatile. Do not induce vomiting because it
increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.

Most Important Symptoms/Effects

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Overexposure may cause anesthetic action, headache, dizziness,tunnel vision, nausea, or unconsciousness.

Suitable extinguishing media:

Dry chemical, CO2, dry sand, or alcohol-resistant foam

Unsuitable extinguishing media:

Water spray, Foam extinguisher

Firefighting instructions:

Move containers from fire area if it can be done without risk, if
not possible, apply water from a safe distance to cool andprotect surrounding area.

Symptoms/effects

5. Fire fighting measures

Fight fire from windward.
Dry chemical powder, carbon dioxide or dry sand should be used
for small fires. Alcohol-resistant foam extinguisher is effective
for a large scale fire.
Personal protection (Emergencyresponse):

Firefighters should wear protective equipment.

6. Accidental release measures
Personal Precautions, Protective Equipment and Emergency Procedures
General measures:

Wear proper protective equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind and evacuate
people downwind. Remove all sources of ignition. Keep away
personnel except for authorized ones from spillage area by
stretching ropes.

:

Attention should be given to avoid discharge of spilled productinto rivers and resulting environmental damage. When diluting
spill with large amounts of water, discharge of untreatedwastewater into the environment must be avoided.

Environmental precautions
Environmental precautions

Methods and Equipment for Containment and Cleaning up
For containment:

Absorb spill with inert material （e.g, diatomaceous earth,sand） and flush spillage area with copious amounts of water.
Remove nearby sources of ignition and prepare extinguishingmedia.

7. Handling and storage
Handling
Technical measures:

Wear proper protective equipment to avoid contact with skin orinhalation of vapor. Fire is strictly prohibited.
Ventilate well at working places.

Precautions for safe handling:

Use with an enclosed system or a local exhaust ventilation. Usein well-ventilated areas.
Do not allow contact with oxidizing substances.

Storage
Storage conditions:

Store in a dark, cool place and tightly closed.

Material used inpackaging/containers:

Glass, stainless steel.
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

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8. Exposure controls / Personal protection equipment
ACGIH TWA

20 ppmACGIH STEL

75 ppmAppropriate engineeringcontrols
Protective equipment: Use with an enclosed system or a local exhaust ventilation.

Respiratory protection: Chemical cartridge respirator with an organic vapor cartage orairline respirator

Hand protection: Impervious protective gloves

Eye protection: Safety goggles

Skin and body protection: Protective clothing, protective boots

9. Physical and chemical properties
Physical state: LiquidColor: Colorless.

Odor: Slight ketone odor

pH

: No data available

Melting point: -84.7 °C

Freezing point: No data available

Boiling point: 115.9 °C

Flash point: 15.6 °C

Auto-ignition temperature: 465 °C

Decomposition temperature: No data available

Flammability: Flammable

Vapor pressure: 22 hPa (21.7℃)

Relative density: No data available

Density: 0.796 g/cm³ (25℃)

Relative gas density: 3.45Solubility: Organic solvents: Readily soluble in ethanol, diethyl ether,benzene.
Water: 1.91 % (25℃): 1.31

Partition coefficient noctanol/water (log Pow)
Explosive limits (vol %): 7.6 – 1.35 vol %Viscosity, kinematic:: 0.69 mm²/s (25℃)

Particle characteristics: No data available

10. Stability and reactivity
Reactivity: May react with oxidizing substances.

Chemical stability: Stable under normal conditions.

Possibility of hazardous
reactions: Stable under normal conditions of use.

Conditions to avoid: Light, heat.

Incompatible materials: Oxidizing substances.

Hazardous decomposition: Carbon monoxide.

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products

11. Toxicological information
Acute toxicity (oral)
Acute toxicity (dermal)
Acute toxicity (inhalation): No classification
rat LD50=2080mg/kg: No classification
rabbit LD50>3000mg/kg: No classification (gas)Toxic if inhaledClassification not possible (dust, mist): rat LC50=1986-3936ppm/4h

Acute toxicity (vapor) Description
Skin corrosion/irritation:

Serious eye damage/irritation:Respiratory sensitization
Skin sensitization
Germ cell mutagenicity:::

Carcinogenicity:

Reproductive toxicity:

No classification
There is a report that in a skin irritation test with rabbits, as aresult of an occlusive application with this substance for 10hours, erythema was persistent until after 24 hours. In addition,
there is a report that in a skin irritation test with guinea pigs,
as a result of an application of this substance (5 or 10 mL),slight irritation was observed.
Causes eye irritation
There is a report that in an eye irritation test (OECD TG 405) withrabbits, as a result of application with a 0.1 mL undiluted
solution of this substance, corneal opacity, conjunctival redness
and conjunctivitis were observed, but they resolved within 7 days.
In addition, there is a report that in another test with rabbits,
as a result of application with a 0.1 mL undiluted solution of thissubstance, irritation was observed within 10 minutes after
application, and symptoms resolved after 60 hours. From the above,
this substance was classified into category 2B.
Classification not possible
Classification not possible
No classification
As for in vivo, a micronucleus test with mouse bone marrow cells
was negative. As for in vitro, bacterial reverse mutation tests, achromosome aberration test, a micronucleus test, and an unscheduled
DNA synthesis assay with cultured mammalian cells were negative.
There was an equivocal result in a mouse lymphoma test with
cultured mammalian cells, but it was difficult to judge positivesince there was no dose dependency.
May cause cancer
In a 2-year inhalation exposure study in rats, renal tubular
adenomas and adenomas and carcinomas increased in frequency inmales and renal mesenchymal malignancies in females. In addition,
in a 2-year inhalation exposure study in mice, an increased
frequency of hepatocellular adenomas and an increased totalfrequency of hepatocellular adenomas and carcinomas were observedin both sexes. Since there was an increased incidence of tumours
including malignancy in the two species, it was classified into
category 1B because there was adequate evidence of carcinogenicity
in animal studies.
Classification not possible

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STOT-single exposure:

STOT-repeated exposure:

Aspiration hazard:

May cause drowsiness or dizziness
May cause respiratory irritation
In humans, in inhalation exposure, cough, headache, sore throat,dizziness, narcotic effects, central nervous system suppression,
nausea, vomiting, diarrhea, weakness, anorexia, loss ofconsciousness were reported and, in oral ingestion, abdominal pain
in addition to these symptoms were reported. As for experimental
animals, narcotic effects in inhalation exposure (higherconcentration) with mice and guinea pigs and central nervous systemdepression, incoordination, and collapse in other tests with rats
were reported. From the above, this substance has respiratory tract
irritating potential and narcotic effects, and it was classified
into category 3 (respiratory tract irritation, narcosis).
Causes damage to organs (central nervous system) through prolonged
or repeated exposure
In epidemiological studies on 19 workers who were exposed to thissubstance for 20 to 30 minutes daily during the operation of acentrifuge at an Italian business place, the air concentration ofthis substance was 500 ppm near the centrifuge, and 80 ppm in otherrooms. In addition to acute irritation symptoms in the eye, nose,and throat, more than half the workers out of 19 complained ofheadache, anorexia, weakness, stomach ache, nausea, and vomiting as
subjective symptoms, and a few workers complained of insomnia,lethargy, and chest pain, but clinical chemistry results were
within the normal range for all of the workers. It is describedthat even in a follow-up study conducted five years later (the airconcentrations of this substance: 100-105 ppm near the centrifuge,
50 ppm elsewhere), a few workers out of the remaining 14 answeredthat the central nervous symptoms and gastrointestinal symptoms
persisted. From the above, this substance was classified into
category 1 (central nervous system).
Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute
Aquatic chronic

Persistence and degradability
Readily biodegradable
BOD : 84%
Bioaccumulative potential
Low bioconcentrationlog Pow : 1.31
Mobility in soilHigh mobility
Koc : 70

: No classification
Artemia salina EC50=1250mg/L/24h: No classificationPimephales promelas NOEC=57mg/L/31-day

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Hazardous to the ozone layerOzone: Classification not possible

13. Disposal considerations
Ecological waste information: Burn in a chemical incinerator equipped with an afterburnerand a scrubber. Or entrust approved waste disposal companies
with the disposal.

Contaminated container andpackaging: In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)
Proper Shipping Name (IMDG)
Packing group (IMDG)
Transport hazard class(es)(IMDG)Air transport(IATA)
UN-No. (IATA)
Proper Shipping Name (IATA)
Packing group (IATA)
Transport hazard class(es)(IATA)

::
:
:

1245
METHYL ISOBUTYL KETONE
II
3:
:
:
:

1245
Methyl isobutyl ketone
II
3

Marine pollutant: Not applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category:Z
MFAG-No:127

15. Regulatory information
Regulatory information with regard to this substance in your country or region should be examined byyour own responsibility.

16. Other information
Data sources: Solvents Handbook, T, Asahara el, Kodansha Scientific Ltd.
（1976）.
Dangerous Properties of Industrial Materials,6th ed.
N.I.Sax Van Nostrand Reinhold Company（1984）.
Handbook of Dangerous Substances Springer-Verlag Tokyo（1991）.
Handbook of 17322 Chemical Products, The Chemical Daily Co.
（2022）.
NITE Chemical Risk Information Platform (NITE-CHRIP), National
Institute of Technology and Evaluation.

The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully.The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements.The information herein is only provision of information, andit does not represent a guarantee the properties of the product.The Safety Data Sheet(SDS) isprepared based on JIS Z7253.