The Keio Journal of Medicine
INSTRUCTIONS TO AUTHORSThe Keio Journal of Medicine (KJM) publishes originalarticles on research in clinical, laboratory, and experimental
medicine. Reviews (by invitation only), case reports, and correspondence will also be considered.

2. Ethics
Authors must provide assurance that all human and animalstudies were approved by Institutional Review Board(s) (aspecific declaration of approval should be given in the text).

Online Manuscript Submission
Manuscripts should be submitted online via KJM’s online
submission and peer review website (known as ScholarOneManuscripts) at http://mc.manuscriptcentral.com/kjm.
• Simply log on to ScholarOne Manuscripts and follow theonscreen instructions for all submissions (you will need toregister before your first submission to KJM).
• For figures, submission of original and editable artwork
files is encouraged. Digital photograph files should have aresolution of at least 300 dpi.
• If you have any technical problems or questions related
to the electronic submission process or uploading yourfiles, please contact our Support Desk. For other inquiries,
please contact our Editorial Office.

3. Conflict of Interest/Financial Disclosure Statement
Authors should disclose in the online submission system
any commercial affiliation or consultancy that could be construed as a conflict of interest with respect to the submitted
data.

ScholarOne Manuscripts Support Desk (Japan)
Phone: +81-3-3910-4517
E-mail: s1-support@kyorin.co.jp
Open weekdays from 09:00 to 17:00 (closed 12:00 to 13:00) JST
ScholarOne Manuscripts Support Desk (USA)
ScholarOne, Inc., Thomson Reuters
Phone: 434-964-4100/888-503-1050 (U.S.-based numbers)
Open weekdays from 12:00 to 20:30 EST
E-mail: Please send e-mail from “Get Help Now” on the upper right corner of the online submission homepage.
The KJM Editorial Office
School of Medicine, Keio University, 35 Shinanomachi,Shinjuku, Tokyo 160-8582, JAPAN
Phone: +81-3-3353-1211 (Ext. 64023)
Fax: +81-3-3351-3116
E-mail: keio-j-med@imic.or.jp
Prerequisites for Publication
Papers will be received on the understanding that they havenot been published in whole or in part elsewhere.
1. Copyright Transfer
The Editorial Board reserves the right to revise the manuscripts when required. KJM owns all copyright to any work
published in the Journal. Any material submitted, whether
appearing in the journal or not, may not be used, reproduced,
or transmitted without the written consent of KJM.
The Copyright Transfer Statement, which is available at:
http://www.kjm.keio.ac.jp/page/authors_top.html, must besigned by corresponding author and must be submitted to thejournal’s editorial office by uploading it as a PDF file or byfax (+81-3-3351-3116) at the same time that you submit yourmanuscript via ScholarOne Manuscripts.
IMPORTANT: Upon receipt of the Certification for Manuscript Submission, manuscripts are officially recognized assubmissions.

4. Copyright Permissions
Authors wishing to include figures and/or tables that havealready been published elsewhere are required to obtain permission from the copyright owner(s) (and pay any associated costs) for both the print and online formats. The source
should be given in the article.
5. Accelerated Reviews of Manuscripts
The reviewing of manuscripts by the Editorial Committee
may be accelerated on an exceptional basis when publication, if approved, would be urgent. The author must state thespecific reasons for the request to accelerate the review process when submitting the manuscript via ScholarOne Manuscripts. The reasons should be described in the Cover Letterbox or in an attached cover letter.
Types of Manuscripts
1. Original Articles are scientific reports of the results oforiginal research in clinical, laboratory, or experimentalmedicine. New, significant, innovative, and original findings
are suitable as original articles.
2. Reviews are usually invited by the editors. They should
contain at least 1 figure or table.
3. Case Reports should contain information which significantly advances our knowledge on medical sciences or practice and are to be presented as concisely as possible. The
number of references should be kept to an absolute minimum.
Preparation of Manuscripts
Manuscripts should be double-spaced with 3-cm margins
on only one side of the paper. Manuscripts should follow theusual layout for scientific papers and be as brief as full documentation allows (rarely exceeding 20 printed pages).
1. Cover Letter As part of the initial submission, the author
must explain the originality or essence of his/her paper ina cover letter. Revised manuscripts should be accompanied
by a cover letter explaining how the manuscript has beenchanged and a separate point-by-point response to reviewers’comments.

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2. Title Page The title page should bear the title of the paper
and the name(s) of the author(s), together with the address(es)at which the work was carried out. The name, full postal address, and e-mail address of the corresponding author who
will be responsible for reading the proofs should be givenon the first page. A running title must also be provided (notexceeding 50 characters including spaces).
3. Summary A summary must appear on the second page ofthe paper; it should be no longer than 250 words and should
be a single paragraph. It should state the subject, new findings, and conclusions of the article in generally intelligible
terms.
4. Keywords Up to five keywords identifying the nature of
the subject matter may be used to alert readers. Keywords
should be listed below the abstract. Use terms from the medical subject headings list of Index Medicus.
5. Text Papers should be written clearly in good scientificEnglish. Avoid laboratory slang and minimize jargon.
For case reports, the text should be arranged as follows: (1)Introduction, (2) Case Presentation, (3) Discussion.
For original articles, the text should be organized in the following order:(1) Introduction:
The section should contain a clear statement of the purpose of the work, the reasons for undertaking the research, and pertinent background to the study.
(2) Materials and Methods:
Description of methods should be brief, but with sufficient detail to enable the experiments to be repeated bythe readers. The design of the study or experiments, any
specific procedures used, and statistical analyses must bedescribed clearly and carefully. References to other papers describing the techniques may be given. The nameand location (city and state/country) of commercial suppliers of uncommon chemicals, reagents, or instruments
should be mentioned.
(3) Results:
The results should be presented concisely. Tables and figures should be used only if they are essential for the comprehension of the data.
(4) Discussion:
The purpose of the discussion is to interpret the results
and to relate them to existing knowledge in the field.
Information already given in the introduction or results
should not be repeated.
6. Acknowledgments All acknowledgments, including thoseof financial support, should be given here. Acknowledgmentsof people precede those of financial support. Names of grantsources should be spelled out.
7. References References should be numbered consecutively
in the order of citation in the text. Abbreviations for titles ofmedical periodicals should conform to those in the latest edition on Index Medicus. In the reference list, give the namesof all authors. Authors are responsible for the accuracy of thereferences.

(1) Periodicals:
1. Boatman JB, Boucek MM, Rabinovitz MJ: Mitochondrial swelling during cold exposure of the rat and hamster.
Am J Physiol 1962; 202: 1037–1040.
2. Kennedy CR, McCann DC, Campbell MJ, Law CM, Mullee
M, Petrou S, Watkin P, Worsfold S, Yuen HM, Stevenson
J: Language ability after early detection of permanentchildhood hearing impairment. N Engl J Med 2006; 354:
2131–2141.
(2) Books:
1. Irving L: Comparative anatomy and physiology of gas
transport mechanisms. In: Fenn WO, Rahn H, eds, Handbook of Physiology, Washington DC, American Physiological Society, 1964; 177–212.
Only papers that are published or in press may be cited in
the reference list.
8. Tables Tables should be numbered (Arabic numerals) in
the order in which they are referred to in the text. Each tableshould have a brief title, be on a separate page, and be double-spaced throughout. Non-standard abbreviations should
be used sparingly and must be defined in a legend at the bottom of the table. Table citations in the text should be boldface(e.g., Table 1).For table titles, use lower case letters with only
the first letter capitalized.
9. Figures All illustrations (line drawings and photographs)
are classified as figures. Digital photograph files should havea resolution of at least 300 dpi. Figures should be cited in consecutive order in the text. Figure citations in the text should
be boldface. The abbreviation “Fig.” should be used when using parenthesis (e.g., (Fig. 1)), otherwise the word “Figure”
should be spelled out (e.g., Figure 1) throughout the text. If afigure consists of multiple parts, capital letters (A, B, C, etc.)
should be used to label them (e.g., Fig. 1A). Legends for thefigures should be double-spaced, in numerical order, and on a
separate page. Non-standard abbreviations should be definedin legends. For figure titles, use lower case letters with only
the first letter capitalized.
The magnification of microphotographs should be indicatedin the legends or a bar should be included in the figure to indicate the scale (or both). Lettering of figures requires carefulattention. Illustrations may be submitted in the final size orlarger for reduction by the printer. Symbols and lines should
be chosen to remain legible after the degree of reduction thatwill be used.
10. Abbreviations, Symbols, and Typesetting Standard abbreviations for certain substances and for units of measurement do not need to be defined. Other abbreviations that areconsidered to be non-standard should be kept to a minimum
and must be spelled out on first usage, followed by the abbreviation in parentheses. Mark gene names for typesetting
in italics to distinguish them from gene products of the sameor similar name, ad hoc designations for genes, gene segments, and gene clusters, families, complexes, or groups. Ingeneral, genotypes should be italicized; phenotypes should
not be italicized. Using italics for emphasis should be avoided
throughout the text.

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Publication Fees
For page charges, see the table below (not including tax).
The corresponding author will be invoiced after publication.
Monochrome(yen/page)Color(yen/page)¥ 5,000¥ 55,000

The Journal reserves the right to modify the charges without
prior notification.

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