W0930-08-51

Correlation between excipient material
attributes and powder feeder systems
Sri Sharath Kulkarni, Sunil Kumar N, Bernhard Meir, Bas van Laarhoven,
Bastiaan HJ Dickhoff, DFE Pharma, Goch, Germany

Contact Information: sunil.kumarn@dfepharma.com

PURPOSERESULT(S)How Purpose
To Use This Poster Template

Pharmatose
200M®

Custommade coarse

Custommade fineFeeder outcome –Pharmatose

Gravimetric mode®

x50 (μm)

42.6

56.8

32.6

Relative standard

Bulk density (g/ml)

0.59

0.67

Tapped density (g/ml)

0.92

Hausner ratio• Headings – Purpose, Methods, Results, Conclusion.

Carr’s index• QR Code location or size.

Table 1a: Material attributes of Pharmatose® 200M along with custom made grades of coarse and finePharmatose® 200M.

Material attributes

With continuous manufacturing gaining ever so importance inHighlight
this text and replace
it bytyping excipients is vital.
the pharmaceuticalindustry,
useeitherof consistentDoNot
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text, orcopying texta Microsofttheby
performanceof fromexcipientsin different process units
as powder
blenders,
granulatorsWord such
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slidecontinuousand• etc.,
The AAPS logo.
needspasting
it in.to be understood.

Font Raw material feeding is usually one of the first unit operation
1.
2.

CONCLUSION(S)and variations in this step could affect finished product
Font size must be 20 points or larger.
quality. The variations in a feeder can be caused due to the• Title, Author, Affiliation area.
inconsistency
in the material
orfont.
process inaccuracy.
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not center

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Loss-in-weight (LIW) gravimetric feeders with a control system

Fig 1: Experimental setup using a gravimetric loss in weight feeder (Gericke).

METHOD(S)Sections– Purpose,Method(s),Results,
mass
control system,
fixed twin
screw speed) with decreasing
them hard to read.
Conclusions,Charts,
Pictures– may
moved mode (usinghopper level(no materialrefill)
and begravimetric
In a gravimetric mode, the variations between the three grades ofProofread:•Good spelling,grammar,and punctuation
improveyour®
controlsystem,
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was reduced
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systemof theand resized to fit.
credibility.feeder. The feeder in this mode compensates for the variations
materialrefill
360 s). Two
feedratesof 9.5 kg/h and 14 kg/h
Do notrenamethe(~sections.
You
must
includewere studied.
in the material attributes by adjusting the twin screw rpm andPurpose, Method(s), Results, and Conclusion.
andpictures
totellastory:Organizetheminawaythe• Use figuresdelivers a constant feed rate for all the three grades as can beeye can follow.
seen in Figure 2. The relative standard deviation and relative error
The discharged excipients were collected in a bin placed on a®
forallthethreegrades
werelow(Table1b).
Pharmatose
200M
Mettler Toledo weight scale. Weight measurements were taken
Less
isMore:•Many posters have been smothered by the weight ofshowedtheleastvariation,but
thedifferences
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Similarevery 1 s and the data was analyzed by a software developedtoo
by many words. Simplify graphics and figures as much as possible
results were obtained at 9.5 kg/h (results not shown).
Gericke using LabView.
without sacrificing accuracy. Keep cutting your text until you canmade coarse

made fine

0.56

0.91 top navigation.
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Table 1b: Relative standard deviation and relative error for gravimetric feeding at 14 kg/hAdding Graphs

Volumetric feeding

The recommended18font for captions is Calibri, no smaller than 15 pt.
Fig 1: Volumetric
Leftalignedif it refers to a figure on its left. Start the captions rightfeedingof
16
200M of the picture (graph or photo).
atPharmatose
the top edge

Conclusion(s)14Feed rate (kg/h)with custom madegrades of fine andcoarse Pharmatose®
200M at 530 rpm

121086Pharmatose® 200M

4Custom made coarse

20

Custom made fine00,20,40,60,81

Hopper fill (%)

Gravimetric feedingFig 2: Gravimetricfeeding ofPharmatose® 200M
with custom madegrades of fine andcoarse Pharmatose®
200M at 14 kg/hGrafiektitel

6®

The need for consistent excipients with a tight particle size and5is vital to obtain accurate feeding. Volumetric mode operates
4
in a fixedcontrol system (fixed twin screw rpm) and therefore
3
truly represents
the material attributes such as particle size
distribution, bulk density, etc. Using a gravimetric loss-in-weight2
feeder system, constant feeding can be achieved by varying
1
the screw rpm. However, during refiling, the gravimetric system
0switches to Category
a volumetricmode
wherematerial
consistency
again1Category
2
Category
3
Category
4
Series 1
Series 2
Series 3
becomes crucial. Therefore
it is importantto have consistentexcipients and a reliable gravimetric feeding system forprocessing in continuous manufacturing.

15

FUNDING / GRANTS / ENCORE /REFERENCE OR OTHER USE

DFE Pharma offers ObD support and consistent pharmaceutical
excipients for pharmaceutical development and manufacturing
and suitable for Continuous Manufacturing.

14,5
Feed rate (kg/h)

OBJECTIVE(S)Custom

Simple graphs can be created in Microsoft Excel or PowerPoint.
Graphs created in scientific graphing programs (e.g. Sigma Plot,Prism, etc.) must be saved in JPEG or PNG format.

Tips for a Successful Poster(twin screw with varying rpm) are generally used to counter• Focus:
Convey 2-3 findings in simple, clear language.
these variations. However, intrinsic material attributes suchasparticle size distribution (PSD), flow, bulk density, wall friction
Result(s)Conclusion
First: Here’s how many scientists read your paper: Title•etc., could impact the accuracy of powder feeding. Hence, to®
-> Conclusion-> EverythingElse.
To hookforthem,focusgradeson a title
andTheexcipientmaterial
attributes
differentofstudy
andunderstandthese
correlations,standardPharmatose
How to use this poster template…
®
conclusionPharmatosethat will gain
theircanattention.
200M
be seen in Table 1a. A screw speed of200M (DFE Pharma, Germany) along with custom made fine
Simply andhighlight
thistextandreplace
itbytyping
inyour®
530 rpm was used to feed the excipients in a volumetric mode.
coarse grade of Pharmatose 200M were analyzed.
Data:• Data, Data,
own text, or copy and paste your text from a MS Word
Scientists
wanttoseeadata-driven
conclusion,
Figure 1 shows the feed rate of the three grades at varying
document or a PowerPoint slide presentation.
not a promiseto levels(Thedo the research.
hopperhopper is completely filled at the start and isMethod(s)allowed to drain till empty). As seen in the figure, the feed rate ofposter must match exactly, the accepted• Titles: The title of your®
®
Pharmatose 200M and the custom made fine and coarse
Pharmatose 200M was consistently dosed in between the feedposter abstract.
grades of Pharmatose® 200M were supplied by DFE Pharma,
rate range of custom made coarse and fine grade of Pharmatose®
Germany. Powder feeding systems was manufactured by• Use Capitalization
200M. Dueto the tightparticle
size
distribution
anddensity
ofSparingly:
Words
andsentences
writtenin
Gericke AG , Switzerland.
Pharmatose® 200M, the variations caused during feeding werecapital letters are hard to read.
reduced. Therefore it shows the need for consistent excipients toSections
maintainfeeding in a volumetricmode.
Make aconstant
Point: Underlining• Use Bold toand italicizing
words makeThe feeder was operated in two modes, volumetric (disabledInserting Pictures200M

Custom1413,513

Pharmatose 200M
Custom made coarse

12,512

Promote Your Poster!

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Custom made fine

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Time (s)600

800

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