1/5Urease
First issue : Apr. 2, 2012
Revised: May. 31. 2022
SDS No.610F

Material Safety Data Sheet
1

Product and Company Identification
Product Name
Product CodeSupplierName
Address
Department
Phone
Fax
Recommended use and restrictions onuse

UreaseURH-201TOYOBO CO.,LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan
Biotechnology Overseas Sales and Marketing Department+81-6-6348-3846+81-6-6348-3833
diagnostic product2 Hazard Identification
Most Important Hazards and Effects

GHS classification
Physical hazards
Health hazards-: Classification not possible

Environmental hazards

The product might be harmful if swallowed.
Causes damage to organs through prolonged orrepeated exposure. (kidney)
Classification not possible
Acute toxicity - Oral
Acute toxicity - Dermal
Acute toxicity - Inhalation (Gas)
Acute toxicity - Inhalation (Vapours)
Acute toxicity - Inhalation (Dust)
Acute toxicity - Inhalation (Mist)
Skin corrosion/irritation
Eye damage/irritation
Sensitization - Respiratory
Sensitization - Skin
Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ systemic toxicity(Single exposure)Specific target organ systemic toxicity(Repeated exposure)
Aspiration toxicity
Hazardous to the aquatic environment(Acute hazard)
Hazardous to the aquatic enviromnent(Chronic hazard)

521(kidney)33

2/5Urease
First issue : Apr. 2, 2012
Revised: May. 31. 2022
SDS No.610F

Material Safety Data Sheet
Label elements
SymbolSignal word
Hazard statements

Prevention

Harmful to aquatic life with long lasting effectDo not handle until all safety precautions have beenread and understood.

ResponseDo not eat, drink or smoke when using this product.
Wear protective gloves.
Wear protective eye/face protection.
Use ventilation equipment or respiratory protection
if necessary.
Do not breathe dust/fume.
Avoid release to the environment
Wash hands thoroughly after handling.
Call a POISON CENTER or doctor if you feel unwell.
IF ON SKIN: Wash with plenty of soap and water. Ifskin irritation occurs, get medicaladvice/attention.
IF IN EYES: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easyto do. Continue ringing.
Store locked up.
Dispose of contents and container in accordance withregulation.

Storage
Disposal

3Danger
May be harmful if swallowed
Suspected of damaging fertility or theCauses damage to organs through prolonged orrepeated exposure (kidney)

Composition/Information on Ingredients
Substance/Preparation
Preparation
Chemical Nature
UreaseCAS#9002-13-5
Amounts contained
16%(W/W)
Ingredients Contributing to the Hazard
Chemical name
Ethylenediaminetetraacetate
Abbreviation
EDTA
Amounts contained
11%(W/W)
Chemical formula
C10H16N2O8
CAS#60-00-4

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UreaseFirst issue : Apr. 2, 2012
Revised: May. 31. 2022
SDS No.610F

Material Safety Data Sheet
4First Aid Measures
Inhalation
Skin Contact
Eye ContactIngestion

Remove to fresh air. Consult a physician whenunpleasantness occurs.
Wash off with plenty of water.
Rinse off with running water for 15 minutes or
longer immediately, consult a physician afterwards.
Swill plentiful amount of water or milk for
immediate vomiting, consult a physician.

5 Fire Fighting Measures
Extinguishing Media
Protection of Firefighters

Water spray, dry chemical powder, or carbon dioxide
etc.
Avoid working at leeward.

6 Accidental Release Measures
Personal Precautions
Environmental PrecautionsMethods for Cleaning up

Wear protective gear to avoid eye/skin contact andinhalation. Do not work at leeward.
High concentrated waste fluid should not be directly
discharged into rivers.
Use cloth, paper or anything similar to soak up thesolution leaking out of the container. Take up undervacuum using dust collecting filter, wash residual
spill with copious amounts of water (Waste water
should be treated with activated sludge etc.).

7 Handling and Storage
Handling
Technical Measures

Precautions
Safe Handling AdviceStorage
Technical Measures
Incompatible Products
Storage ConditionsPackaging Materials

Wear protective gear to avoid eye/skin contact andinhalation. Do not drop the container to prevent thecontent popping out.
None specified.
Wear protective gear, avoiding contact on eye, skinand cloths.
Keep sealed container in refrigerator.
None specified.
Store under -20℃.
Use the initial container of the product.

8 Exposure Controls/Personal Protection
Engineering Measures
Personal Protective Equipment
Respiratory Protection
Hand Protection
Eye Protection
Skin and Body Protection

Provide shower and vanity unit nearby.
Protecting mask.
Protecting gloves(rubbers or plastic gloves etc.).
Safety goggles.
Long sleeve working wear.

4/5Urease
First issue : Apr. 2, 2012
Revised: May. 31. 2022
SDS No.610F

Material Safety Data Sheet
9 Physical and Chemical Properties
Physical State, form and colour

Solid, powder, whiteOdour
pH
Decomposition Temperature
Flash Point
Density
Solubility

No odourApproximate pH7.5 in the case of 10 mg/ml in water.
No information available.
No information available.
No information available.
Freely soluble in water.

10 Stability and Reactivity
Stability

Stable at temperatures below -20℃. Proteins, whenleft for long at room temperature, might bedegraded, which does not cause any hazardous
reaction though.

Possible hazard reactions at specific Not specified.
condition
Conditions to avoid
Prolonged storage under higher temperature than room
temperature and high humidity.
Materials to avoid
Any materials which dissolve or destroy proteinssuch as strong acid or alkali.
Hazardous Decomposition Products
No information available.

11 Toxicological Information
Though there is no information about this product, there are information about EDTA asfollows.
Acute Toxicity (Oral)
Rat LD50 2580mg/kg
Temporal Edema/Rubefaction/Opacity of the cornea
Eye damage/irritation
were observed in test on rabbit.
Toxic to reproduction
Birth defect was observed in test on animals.
Specific target organ systemic toxicity A case of human kidney damage was reported.
(Repeated exposure)

12 Ecological Information
Though there is no information about this product, there are information about EDTA asfollows.
Algae (Selenastrum); 72hErC50=6mg/L
Ecotoxicity
Bioaccumulative potential
Bio-concentration factor (BCF) =123
Persistence and degradability
Hardly biodegradable (0% by BOD)

13 Disposal Considerations
Waste from Residues
Contaminated packaging

Dispose of protein in accordance with all applicable
local and national laws and regulations.
Wash with copious amounts of water and waste
conforming to local regulations depending on thetype of the material.

5/5Urease
First issue : Apr. 2, 2012
Revised: May. 31. 2022
SDS No.610F

Material Safety Data Sheet
14 Transport Information
International Regulations
Specific Precautions

None specified (Not classified as hazardous material
as per the UN recommendation).
Keep at temperatures below -20℃.

15 Regulatory Information
Regulations

None specified.

16 Other Information
Notice

The contents specified here is made based on thedocuments, information or data which are currently
available and subject to revision in the future.
TOYOBO makes no warranty and assumes no liability
whatsoever in connection with any use of thisinformation.