1
論文
1.

Yasumasu S, Shimada H, Inohaya K, Yamazaki K, Iuchi I, Yasumasu I, Yamagami K: Different exon-intronorganizations of the genes for two astacin-like proteases, high choriolytic enzyme (choriolysin H) and low
choriolytic enzyme (choriolysin L), the constituents of the fish hatching enzyme. Eur J Biochem. 237:752-8,
1996.

2.

Mitsunaga-Nakatsubo K, Yamazaki K, Hatoh-Okazaki M, Kawashita H, Okamura C, Akasaka K, Shimada H,
Yasumasu I: cDNA cloning of Na+, K(+)-ATPase alpha-subunit from embryos of the sea urchin,
Hemicentrotus pulcherrimus. Zoolog Sci. 13:833-41, 1996.

3.

Yamazaki K, Maruyama T, Ihara T, Yasumasu I: Behavior of Na+/K(+)-ATPase alpha-subunit alleles in sea
urchin eggs upon fertilization. Dev Growth Differ. 39:105-9, 1997.

4.

Inohaya K, Yasumasu S, Araki K, Naruse K, Yamazaki K, Yasumasu I, Iuchi I, Yamagami K: Speciesdependent migration of fish hatching gland cells that express astacin-like proteases in common. Dev GrowthDiffer. 39:191-7, 1997.

5.

Yamazaki K, Okamura C, Ihara T, Yasumasu I: Two types of Na+/K(+)-ATPase alpha subunit gene transcriptin embryos of the sea urchin, Hemicentrotus pulcherrimus. Zoolog Sci. 14:469-73, 1997.

6.

Kawamura A, Yokota S, Yamada K, Inoue H, Inohaya K, Yamazaki K, Yasumasu I, Higashinakagawa T: pc1
and psc1, zebrafish homologs of Drosophila Polycomb and Posterior sex combs, encode nuclear proteinscapable of complex interactions. Biochem Biophys Res Commun. 294:456-63, 2002.

7.

Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M, Hirohashi S: Expression profiling in
multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular
carcinoma. Hepatology. 37:198-207, 2003.

8.

Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S: Overexpression of KIT in chromophobe
renal cell carcinoma. Oncogene. 22:847-52, 2003.

9.

Koide N, Yamada T, Shibata R, Mori T, Fukuma M, Yamazaki K, Aiura K, Shimazu M, Hirohashi S, Nimura
Y, Sakamoto M: Establishment of perineural invasion models and analysis of gene expression revealed aninvariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer. Clin
Cancer Res. 12:2419-26, 2006.

10. Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F,
Imoto I, Ohki M, Inazawa J, Hirohashi S: Genome-wide array-based comparative genomic hybridization
analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Cancer Sci. 98:392-400, 2007.
11. Kuwabara Y, Yamada T, Yamazaki K, Du WL, Banno K, Aoki D, Sakamoto M: Establishment of an ovarian
metastasis model and possible involvement of E-cadherin down-regulation in the metastasis. Cancer Sci.
99:1933-9, 2008.
12. Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S,
Sakamoto M: Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer
cell motility. Lab Invest. 89:425-32, 2009.
13. Hibi T, Mori T, Fukuma M, Yamazaki K, Hashiguchi A, Yamada T, Tanabe M, Aiura K, Kawakami T, Ogiwara

2A, Kosuge T, Kitajima M, Kitagawa Y, Sakamoto M: Synuclein-gamma is closely involved in perineuralinvasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer. Clin
Cancer Res. 15:2864-71, 2009.
14. Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, Kitajima M, Kitagawa Y,
Sakamoto M: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal
cancer. Cancer Sci. 101:1731-7, 2010.
15. Masugi Y, Yamazaki K, Hibi T, Aiura K, Kitagawa Y, Sakamoto M: Solitary cell infiltration is a novel
indicator of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer. Hum Pathol. 41:10618, 2010.
16. Mamiya T, Yamazaki K, Masugi Y, Mori T, Effendi K, Du W, Hibi T, Tanabe M, Ueda M, Takayama T,
Sakamoto M: Reduced transforming growth factor-beta receptor II expression in hepatocellular carcinoma
correlates with intrahepatic metastasis. Lab Invest. 90:1339-45, 2010.
17. Kanamori H, Kawakami T, Effendi K, Yamazaki K, Mori T, Ebinuma H, Masugi Y, Du W, Nagasaka K,
Ogiwara A, Kyono Y, Tanabe M, Saito H, Hibi T, Sakamoto M: Identification by differential tissue proteome
analysis of talin-1 as a novel molecular marker of progression of hepatocellular carcinoma. Oncology. 80:40615, 2011.
18. Yamanoi K, Fukuma M, Uchida H, Kushima R, Yamazaki K, Katai H, Kanai Y, Sakamoto M: Overexpressionof leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. Pathol Int. 3:13-9, 2013.
19. Effendi K, Yamazaki K, Mori T, Masugi Y, Makino S, Sakamoto M: Involvement of hepatocellular carcinoma
biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression. Exp Cell Res.
319:35-44, 2013.
20. Fukuma M, Tanese K, Effendi K, Yamazaki K, Masugi Y, Suda M, Sakamoto M: Leucine-rich repeatcontaining G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular
carcinoma cells. Exp Cell Res. 319:113-21, 2013.
21. Emoto K, Masugi Y, Yamazaki K, Effendi K, Tsujikawa H, Tanabe M, Kitagawa Y, Sakamoto M: Presence ofprimary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma. Hum Pathol.
45:817-25, 2014.
22. Yamazaki K, Masugi Y, Effendi K, Tsujikawa H, Hiraoka N, Kitago M, Shinoda M, Itano O, Tanabe M,
Kitagawa Y, Sakamoto M: Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor
prognosis in pancreatic ductal adenocarcinoma. Lab Invest. 94:683-91, 2014.
23. Effendi K, Yamazaki K, Fukuma M, Sakamoto M: Overexpression of Leucine-Rich Repeat-Containing G
Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular
Carcinoma. Liver Cancer. 3:451-7, 2014.
24. Ueno A, Masugi Y, Yamazaki K, Komuta M, Effendi K, Tanami Y, Tsujikawa H, Tanimoto A, Okuda S, Itano
O, Kitagawa Y, Kuribayashi S, Sakamoto M: OATP1B3 expression is strongly associated with Wnt/β-cateninsignalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma. J Hepatol. 61(5):10807, 2014.
25. Masugi Y, Yamazaki K, Emoto K, Effendi K, Tsujikawa H, Kitago M, Itano O, Kitagawa Y, Sakamoto M:

3
Upregulation of integrin β4 promotes epithelial-mesenchymal transition and is a novel prognostic marker inpancreatic ductal adenocarcinoma. Lab Invest. 95:308-19, 2015.
26. Murayama Y, Satoh S, Hashiguchi A, Yamazaki K, Hashimoto H, Sakamoto M: Visualization of
acetaminophen-induced liver injury by time-of-flight secondary ion mass spectrometry. Anal Biochem.
488:51-8, 2015.
27. Masugi Y, Tanese K, Emoto K, Yamazaki K, Effendi K, Funakoshi T, Mori M, Sakamoto M: Overexpressionof adenylate cyclase-associated protein 2 is a novel prognostic marker in malignant melanoma. Pathol Int.
65:627-34, 2015.
28. Tsujikawa H, Masugi Y, Yamazaki K, Itano O, Kitagawa Y, Sakamoto M: Immunohistochemical molecularanalysis indicates hepatocellular carcinoma subgroups that reflect tumor aggressiveness. Hum Pathol. 50:2433, 2016.
29. Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J,
Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N: Serum Wisteria Floribunda
Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular
Carcinoma. Sci Rep. 7:244, 2017.
30. Fujii-Nishimura Y, Yamazaki K, Masugi Y, Douguchi J, Kurebayashi Y, Kubota N, Ojima H, Kitago M,
Shinoda M, Hashiguchi A, Sakamoto M: Mesenchymal-epithelial transition of pancreatic cancer cells atperineural invasion sites is induced by Schwann cells. Pathol Int. 68:214-223, 2018.
31. Kawaida M, Yamazaki K, Tsujikawa H, Fukuma M, Abe Y, Kitago M, Shinoda M, Kitagawa Y, Sakamoto M:
Diffuse and canalicular patterns of glypican-3 expression reflect malignancy of hepatocellular carcinoma.
Pathol Int. 69:125-134, 2019.
32. Ueno A, Masugi Y, Yamazaki K, Kurebayashi Y, Tsujikawa H, Effendi K, Ojima H, Sakamoto M: Precision
pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision
diagnosis of hepatocellular carcinoma. Pathol Int. 70:140-154, 2020.
33. Minagawa T, Yamazaki K, Masugi Y, Tsujikawa H, Ojima H, Hibi T, Abe Y, Yagi H, Kitago M, Shinoda M,
Itano O, Kitagawa Y, Sakamoto M: Activation of extracellular signal-regulated kinase is associated with
hepatocellular carcinoma with aggressive phenotypes. Hepatol Res. 50:353-364, 2020
34. Wagatsuma T, Nagai-Okatani C, Matsuda A, Masugi Y, Imaoka M, Yamazaki K, Sakamoto M, Kuno A:
Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of
Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets. Front Oncol.
10:338, 2020.
35. Kubota N, Ojima H, Hatano M, Yamazaki K, Masugi Y, Tsujikawa H, Fujii-Nishimura Y, Ueno A,
Kurebayashi Y, Shinoda M, Kitago M, Abe Y, Kitagawa Y, Sakamoto M: Clinicopathological features ofhepatocellular carcinoma with fatty change: Tumors with macrovesicular steatosis have better prognosis andaberrant expression patterns of perilipin and adipophilin. Pathol Int. 70:199-209, 2020.
36. Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M:
Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer
correlates with aggressive histologic types and worse outcomes. Jpn J Clin Oncol. 50:643-652, 2020.

4
37. Kwa WT, Effendi K, Yamazaki K, Kubota N, Hatano M, Ueno A, Masugi Y, Sakamoto M: Telomerase reverse
transcriptase (TERT) promoter mutation correlated with intratumoral heterogeneity in hepatocellular
carcinoma. Pathol Int. 70:624-632, 2020.
38. Ogawa Y, Masugi Y, Abe T, Yamazaki K, Ueno A, Fujii-Nishimura Y, Hori S, Yagi H, Abe Y, Kitago M,
Sakamoto M: Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of
Fibroblast Subpopulations and Collagen. Clin Cancer Res. 27:107-119, 2021.
39. Kurebayashi Y, Matsuda K, Ueno A, Tsujikawa H, Yamazaki K, Masugi Y, Kwa WT, Effendi K, Hasegawa Y,
Yagi H, Abe Y, Kitago M, Ojima H, Sakamoto M: Immunovascular classification of HCC reflects reciprocalinteraction between immune and angiogenic tumor microenvironments. Hepatology. 75:1139-1153, 2022.
40. Matsuda K, Kurebayashi Y, Masugi Y, Yamazaki K, Ueno A, Tsujikawa H, Ojima H, Kitago M, Itano O,
Shinoda M, Abe Y, Sakamoto M: Immunovascular Microenvironment in Relation to Prognostic Heterogeneity
of WNT/β-catenin-Activated Hepatocellular Carcinoma. Hepatol Res. 53:344-356, 2023.
総説
Yamazaki K, Masugi Y, Sakamoto M: Molecular pathogenesis of hepatocellular carcinoma: altering transforming
growth factor-β signaling in hepatocarcinogenesis. Dig Dis. 29:284-8, 2011.
著書1.

福間真理子, 山崎剣, 坂元亨宇. 膵癌の病理学的特性－分子機構の解明－. 画像診断 26:13-18, 2006

2.

山﨑剣, 真杉洋平, 坂元亨宇. 膵癌の浸潤・転移における EMT の役割. 実験医学 27:103-106, 2009

学会報告
1.

山﨑剣, 眞杉洋平, 坂元亨宇: Adenylate cyclase-associated protein 1 promotes pancreatic cancer cell
motility. 第 68 回日本癌学会学術総会, 横浜, 2009.10

2.

Ken Yamazaki, Yohei Masugi, Kathryn Effendi, Michiie Sakamoto: SMAD3 upregulation is a novel
biomarker of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer. AACR 104th Annual
Meeting 2013, Washington DC, USA, 2013.4

3.

辻川華子, 真杉洋平, Kathryn Effendi, 山崎剣, 坂元亨宇: 肝細胞癌における biliary/stem cell marker の発現. 第 102 回日本病理学会総会, 札幌, 2013.6

4.

Yohei Masugi, Ken Yamazaki, Katsura Emoto, Kathryn Effendi, Minoru Kitago, Osamu Itano, Yuko
Kitagawa, Michiie Sakamoto: Up-regulation of integrin β4 promotes epithelial-mesenchymal transition and isa novel prognostic marker in pancreatic cancer. AACR Annual Meeting 2014, San Diego, USA, 2014.4

5.

Takayoshi Tanaka, Yasuo Sugitani, Tokiya Abe, Miho Kawaida, Ken Yamazaki, Akinori Hashiguchi, Michiie
Sakamoto, Toshihiko Ohtomo: Immunofluorescent digital slide technology to evaluate correlation between
Glypican-3 expression and response to codrituzumab. AACR 107th Annual Meeting 2016, New Orleans,
USA, 2016.4

56.

川井田みほ, 山崎剣, 阿部時也, 辻川華子, 橋口明典, 田中孝欣, 大友俊彦, 板野理, 尾島英知, 坂元
亨宇: 肝細胞癌における Glypican-3 の細胞内局在ならびに発現量と臨床病理学的検討. 第 106 回日本病理学会総会, 東京, 2017.4

7.

山﨑剣, 眞杉洋平, 辻川華子, 尾島英知, 北郷実, 篠田昌宏, 北川雄光, 坂元亨宇: ムチン 1 発現は肝細胞癌の悪性度を反映する. 第 77 回日本癌学会学術総会, 大阪, 2018.09

8.

辻川華子, 山﨑剣, 真杉洋平, 坂元亨宇: 肝細胞癌におけるインテグリン β4 発現の意義. 第 108 回日
本病理学会総会, 東京, 2019.5

9.

西村瑶子, 真杉洋平, 橋口明典, 道口洵也, 山崎剣, 尾島英知, 北郷実, 板野理, 北川雄光, 坂元亨宇:
膵癌神経周囲浸潤部における focal differentiation の意義の検討. 第 79 回日本癌学会学術総会, 広島,
2020.10

10. 紅林泰, 松田紘典, 上野彰久, 辻川華子, 山崎剣, 眞杉洋平, エフェンディ カトリーヌ, クワ ウィト
ゥン, 尾島英知, 坂元亨宇: 肝細胞癌の免疫・血管微小環境に基づく分類：免疫チェックポイント阻害剤併用療法の効果予測を見据えて. 第 111 回日本病理学会総会, 神戸, 2022.4
11. 紅林泰, 松田紘典, 辻川華子, 上野彰久, kathryn Effendi, 山崎剣, 眞杉洋平, 尾島英知, 坂元亨宇: 肝細胞癌に対する抗腫瘍免疫応答の発達・疲弊過程の時空間的解析と臨床病理学的意義. 第 112 回日本病理学会総会, 下関, 2023.4