¸¹=º»P¼½

@ 15g- ῌ῍῎       ῏ῌ  ῍  ῎    ῏  !"#$% &'()*J[za `) b 10 8MA+,- ./0 #1234 56. 3 7891.

GABA 

!"#$%&'(): !" #$.;6# :<=6>?@:A BC.D%E*F&G'(H)I 2003 * ? 15 JK+.D%.,-cdG.[z.v [`J[za.`efU!LM9? N../*0##1+1 O!: 100 .[z8gh GABA.0P.?LQLQ2RQ:#ST%4U!

*MA GABA 8 CQ:[zi. 5Or j:A .V3W!?@:456 78X 130

 Lactococcus lactis # Streptococcus thermophilus  GABA

Y139 mmHg LMZ9X 85Y89 mmHg [\]W

C^!k!"#T9%4MA N"? ". 2 Z 78X 140Y159 mmHg LMZ9X 90

U q%b-*8lM  100.

Y99 mmHg [!U :;<= #^ _m/? x*z8 GABA mQ: Lc. lactis YIT 2027>;?@A`,(ab-cd# :M9 BCe8f9MC

8 GABA C N[z#UnoMA 8N!UeDg.hE?8i* j- Q:"#F=?@:A k[8(`M [ GABA .pi# : x*zlBGm?@:"#\nH%4U!: I? BJK.qris !M9 t % GABA XuMv

L.MopN)Iq4U!:1.1OrU[w $MA_ N48SPUst(*q4MBJ8QRQ:"#1Gm.`#U [*C8b-x.¡Kdxyz. 20

?@uvA ".\v wS$%BJ#UT9%4U!: g- d89:xyUz GABA VWMA GABA X{|nLYQGABA mq¢:yz8STMA 1 Z? GABA:dxyz.Z? }opN81~"#n$%H%n $~ x*zqre{.!#!v|~.^814U!:A 44 [z.\]^8NU [KL~.b-*8M }~ .S?f $% GABA 8C£!¤¢ $MA N"?  x*z8qrq¢:^

Q:IA8_ &GABA fG[`

x*z8 [z.pN?qrq¢ "48C^.![z8b-* Lc. lactis YIT 2027 #.
¥¦'\_m/3 GABA 8 CQ:IA8§¨MA N. ©-ª`e N!%4:.V3! x*zqr^8« Lactobacillus casei strain Shirota Lb.
johnsonii YIT 0284 Lc. cremoris YIT 2007j4U!MA N.?1 Lb. casei strain Shirota ¬{Tq4U[_ B­®1!"#$% x*zqre{.!
[z#UnoQ:"#MA K+.b-*
8LT Lc. lactis YIT 2027 # Lb. casei strain Shirota . 2
8¥¦'M#"u XuM . GABA  Cq4:"#8T9M j¯ 3172150 °A
2.

GABA   +,-./01 23456

789:34;<=>p±.IA?(`M GABA fG[`J[za `) 8 ®?²³MIA? X
,(SHR/Izm) @:!N.i*,

(WKY/Izm) ­O:M#"u SHR/Izm .

j- ?@:45¨}opNT9%4 LM . GABA 8:U1
 %4MA MU s . GABA .­O:
? 45´µ8T¶ .¨}m8«? 1 GABA fG[`J[za `)

Q"#«·q4MA "."# QRQ:BJ#U

% 16³U´²µ¶·¸¹  GABA  !" # $%&' %( 3.

º¸3»¼½

 w GABA /12$@9  12%0*CC v4w&f
2y&@tJ# &>GABA   !"4.

' %( GABA  !"#GABA %12fxy&@b'  1950 ?@wA)*$+,-.$/01234560123 M% OC2B@MCy& ;M

%789:;<= & *>?@*?A GABA 1CD@E&* F9$X

BCD12@EFGH;IJ ' %K &LMN OC>?CPQ

M GABA 12fxy&C!w &LM&wL O'kk G¡C¢7$HI SHR/Izm @&M

 !" @R STCUV@WL &X J,MCOC@UJ OCsT GABA Cf2y&£YZI[F\]$^_

3$M`a $bMc& !@W "d$- #e@$Mf2@%&&/0123X-g560123 86'@R$ GABA  !" CS # @(hJ )K*U+Wij%Wk 10mg / 100 mL / , C GABA @  l   !"GABA @&7mn op @ 1 - 1 ,.qr OCsT / 2 $t-.$  !" C.q$-u12
v4w$0x OCy&z1 &@2{J12 &3C$v4w$4 |}@t :~FR
 *&wL  # & RC5&wL bM /0123C

108 '@R$)

K*U+Wij@ #6$e&12fxy& #@( GABA  !" >* /123%.qJ 7 O' /123@R #6&@ OCsT /123C
12fxr&' %!w &L 'C'  3+C8$XM SHR/Izm C12fxr% /12

WKY/Izm C12$@9&wLsT P: $4C;x$&>
* .qC:

' w 1 -$ 3 ,&J @ $&M<C12fxy&%&'  =>&y&5&' @($3SHR/Izm CNO8PY$ GABA X-gOC=­G ® =F¯­G@QQr ¤CRQ2 °I=±:FSCT²L§¨SEM. ῌp©0.05, ῌῌp©0.01: EFGH;I$
J Dunnett UM$ 2 /0123X-g560123$ GABA   !" @F9 ¤C12CK¥ (n¦86)
L§¨SEM. #p©0.05, ##p©0.01: 7mni$J ªC& t UM , ῌp©0.05, ῌῌp©0.01: .q«¬-$J Dunnett UM¦§£¹º¨©

»ª¼4§½ a1  P[; 9.)QP[;jk  lmnop)XRP[;&.kST"/.* Uqr9./%&'( JVsWt&.kB %& J[;)"* )+,+- ./)+uZ%&Hv* J&JVs&.kXwS012)" 3!4"#&5$x yH>?.z _{|Y},+Z['\~67&%8 GABA 9: GABAB ?* GABA ῏ 17

!"#$>?@ABCD E3$F

;<=]AO^?' _.=2,&GH;IJ+)+W`)S%&;?8k* Uab GABAB ;<= >?

GABA 3JKLJVsTc    2004 d eKABCD)"%&'L,7 M' 3N* '7fgh2 `E3uZie >j&klmn nL&/ ( GABAB %&' !

O)'PQ+"* )+/op* %%& UKL37 q7GABA *R+,)S& T-.&/.'0U J>V^ =_ ilr'p+"&&jQ* e

E6=Y7'3W8fgh `nosU 21e & E3 2 mmHg 8F)S

FX%&9Z* %%& GABA ':[;\])%& d 2 tZu'v,&.k* W_Q/.%&X?7* !% :<

JKL'E3'uZiwxI%&.

= SHR/Izm  ./5$5Z* GABA  :

.*

12'3W45X%&

=. SHR/Izm >/?@AE3$F

L"L"%",+yz;7{Z|e}[;' = SHR/Izm  $3

9~ !XWt/ Zm

Z+",7*E6=Y7 :=?

no05'qrW /..&PQ*. GABA +,23W8%&'9Z+"
* %"+BC,+ GABA E3$F^=_UqrW5Z2 ". `GABA 'X%&2aDGH;IL4qrJ%&')"/(b'EcX%& FG¤¥¦F * §¨ ©ª«¬¬:<9./ =%&')"J>V 124* ­ ®Z&Xei . X*5'd%%&e 2HIX&PQ+"*¯°UqrW ±AH>U¡9²¢O³£'

5. ῍ ῌ ῎`Zmno¤´/e µ/5Z¶·?%&¥¸JKL) f 3g7M3X* hNO&/iX* ¡¢£