＜統合研究による発表論文一覧＞

1. Fujita Y, Shinkai S, Taniguchi Y, Miura Y, Tanaka M, Ohsawa I, Kitamura A,
Ito M. Association Between Serum GDF15 Concentration and Total Mortality
in Community-Dwelling Japanese Older Populations: The Involvement ofRenal Dysfunction. J Gerontol A Biol Sci Med Sci . 2023 Aug 27;78(9):17011707.
2. Kitago M, Seino S, Shinkai S, Nofuji Y, Yokoyama Y, Hata T, Abe T, Taniguchi
Y, Amano H, Murayama H, Kitamura A, Akishita M, Fujiwara Y. CrossSectional and Longitudinal Associations of Creatinine-to-Cystatin C Ratio with
Sarcopenia Parameters in Older Adults. J Nutr Health Aging. (in press)
3. Abe T, Seino S, Nofuji Y, Yokoyama Y, Amano H, Yamashita M, Shinkai S,
Kitamura A, Fujiwara Y. Modifiable healthy behaviours and incident disability
in older adults: Analysis of combined data from two cohort studies in Japan.
Exp Gerontol . 2023 Mar:173:112094.
4. Toyoshima K, Seino S, Tamura Y, Ishikawa J, Chiba Y, Ishizaki T, Fujiwara
Y, Shinkai S, Kitamura A, Araki A. Difference between "physical fitness age"
based on physical function and chronological age is associated with obesity,
hyperglycemia, depressive symptoms, and low serum albumin. J Nutr
Health Aging (in press) (Toyoshima K and Seino S contributed equally tothis work).
5. Ikeuchi T, Yano Y, Sato W, Morikawa F, Toru S, Nishimura C, Miyazawa N,
Kuroha Y, Koike R, Tanaka S, Utsumi K, Kasuga K, Tokutake T, Ono K,

Yano S, Naruse S, Yajima R, Hamano T, Yokoyama Y, Kitamura A, Kaneko
E, Yamakado M, Nagao K. Development of a Novel Nutrition-Related
Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma
Free Amino Acid Profile. Nutrients. 2022 Feb 1;14(3):637. doi:
10.3390/nu14030637.
6. Abe T, Kitamura A, Yamashita M, Kim H, Obuchi, P.S, Ishizaki T, Fujiwara
Y, Awata S, Toba K, IRIDE Cohort Study investigators. Simple screening
models for cognitive impairment in community settings: The IRIDE Cohort
Study. Geriatr Gerontol Int (Online ahead of print), 2022 Feb 20. doi:
10.1111/ggi.14360.
7. Seino S, Kitamura A, Abe T, Taniguchi Y, Murayama H, Amano H, Nishi M,
Nofuji Y, Yokoyama Y, Narita M, Shinkai S, Fujiwara Y. Dose-Response
Relationships of Sarcopenia Parameters with Incident Disability andMortality in Older Japanese Adults. J Cachexia Sarcopenia Muscle (inpress). doi: 10.1002/jcsm.12958.
8. Iwasaki M, Ohara Y, Motokawa K, Hayakawa M, Shirobe M, Edahiro A,
Watanabe Y, Awata S, Okamura T, Inagaki H, Sakuma N, Obuchi S, Kawai
H, Ejiri M, Ito K, Fujiwara Y, Kitamura A, Nofuji Y, Abe T, Iijima K, Tanaka
T, Son BK, Shinkai S, Hirano H. Population-based reference values for
tongue pressure in Japanese older adults: A pooled analysis of over 5,000
participants. J Prosthodont Res, 2022 Jan 27. Online ahead of print. doi:
10.2186/jpr.JPR_D_21_00272.

9. Iwasaki M, Hirano H, Motokawa K, Shirobe M, Edahiro A, Ohara Y, Kawai
H, Kojima M, Obuchi S, Murayama H, Fujiwara Y, Ihara K, Shinkai S,
Kitamura A. Interrelationship among whole-body skeletal muscle mass,masseter muscle mass, oral function, and dentition status in older
Japanese adults. BMC Geriatr, 2021 Oct 20;21(1):582. doi:
10.1186/s12877-021-02552-9.
10. Ishikawa J, Seino S, Kitamura A, Toba A, Toyoshima K, Tamura Y,
Watanabe Y, Fujiwara Y, Inagaki H, Awata S, Shinkai S, Araki A, Harada K.
The relationship between blood pressure and cognitive function. Int J
Cardiol Cardiovasc Risk Prev, 2021;10:200104. doi:
10.1016/j.ijcrp.2021.200104.
11. Ozawa T, Yamashita M, Seino S, Kamiya K, Kagiyama N, Konishi M, Saito
H, Saito K, Ogasahara Y, Maekawa E, Kitai T, Iwata K, Jujo K, Wada H,
Kasai T, Momomura S, Hamazaki N, Nozaki K, Kim HK, Obuchi S, Kawai H,
Kitamura A, Shinkai S, Matsue Y. Standardized gait speed ratio in elderly
patients with heart failure. ESC Heart Failure, 2021 Oct;8(5):3557-3565.
doi: 10.1002/ehf2.13392.
12. Makizako H, Nishita Y, Jeong S, Otsuka R, Shimada H, Iijima K, Obuchi S,
Kim H, Kitamura A, Ohara Y, Awata S, Yoshimura N, Yamada M, Toba K,
Suzuki T. Trends in the prevalence of frailty in Japan: A meta-analysis fromthe ILSA-J. Journal of Frailty & Aging (in press).

13. Kitamura A, Seino S, Abe T, Nofuji Y, Yokoyama Y, Amano H, Nishi M,
Taniguchi Y, Narita M, Fujiwara Y, Shinkai S. Sarcopenia: prevalence,associated factors, and the risk of mortality and disability in Japanese older
adults. Journal of Cachexia, Sarcopenia and Muscle. 2021 Feb;12(1):3038. doi: 10.1002/jcsm.12651. Epub 2020 Nov 25.
14. Yokoyama Y, Kitamura A, Seino S, Kim HK, Obuchi S, Kawai H, Hirano H,
Watanabe Y, Motokawa K, Narita M, Shinkai S. Association of nutrientderived dietary patterns with sarcopenia and its components in communitydwelling older Japanese: a cross-sectional study. Nutr J. 2021 Jan
18;20(1):7. doi: 10.1186/s12937-021-00665-w.
15. Abe T, Kitamura A, Seino S, Yokoyama Y, Amano H, Taniguchi Y, Nishi M,
Nofuji Y, Ikeuchi T, Sugiyama T, Shinkai S. Frailty status and transport
disadvantage: comparison of older adults' travel behaviours between
metropolitan, suburban, and rural areas of Japan. Int J Environ Res Public
Health, 2020 Sep 1;17(17):6367. doi: 10.3390/ijerph17176367.
16. Suzuki T, Nishita Y, Jeong S, Shimada H, Otsuka R, Kondo K, Kim H,
Fujiwara Y, Awata S, Kitamura A, Obuchi S, Iijima K, Yoshimura N,
Watanabe S, Yamada M, Toba K, Makizako H. Are Japanese older adults
rejuvenating? Changes in health-related measures among older community
dwellers in the last decade. Rejuvenation Res. 2020 Jul 8. doi:
10.1089/rej.2019.2291.

17. Maekawa K, Ikeuchi T, Shinkai S, Hirano H, Ryu M, Tamaki K, Yatani H,
Kuboki T, Kusatsu ISLE Study Working Group Collaborators,* Kimura-Ono
A, Kikutani T, Suganuma T, Ayukawa Y, Gonda T, Ogawa T, Fujisawa M,
Ishigaki S, Watanabe Y, Kitamura A, Taniguchi Y, Fujiwara Y, Edahiro A,
Ohara Y, Furuya J, Nakajima J, Umeki K, Igarashi K, Horibe Y, Kugimiya Y,
Kawai Y, Matsumura H, Ichikawa T, Ohkawa S. Number of functional teeth
more strongly predicts all-cause mortality than number of present teeth inJapanese older adults. Geriatr Gerontol Int. 2020 Jun;20(6):607-614.
18. Kojima G, Taniguchi Y, Kitamura A, Fujiwara Y. Is living alone a risk factor
of frailty? A systematic review and meta-analysis. Ageing Research
Reviews. 2020 May;59:101048. doi: 10.1016/j.arr.2020.101048.
19. Seino S, Kitamura A, Abe T, Taniguchi Y, Yokoyama Y, Amano H, Nishi M,
Nofuji Y, Narita M, Ikeuchi T, Fujiwara Y, Shinkai S. Dose-Response
Relationships between Body Composition Indices and All-Cause Mortality inOlder Japanese Adults. J Am Med Dir Assoc. 2020 Jun;21(6):726-733.e4.
doi: 10.1016/j.jamda.2019.11.018.
20. Osuka Y, Kim H, Kawai H, Taniguchi Y, Yokoyama Y, Seino S, Obuchi S,
Kitamura A, Shinkai S. Sarcoscore: a novel approach for assessing
sarcopenia and functional disability in older adulsts. J Clin Med. 2020 Mar
4;9(3). pii: E692. doi: 10.3390/jcm9030692.
21. Abe T, Kitamura A, Seino S, Yokoyama Y, Amano H, Taniguchi Y, Nishi M,
Narita M, Ikeuchi T, Tomine Y, Fujiwara Y, Shinkai S. Differences in thePrevalence of and Factors Associated with Frailty in Five Japanese
Residential Areas. Int J Environ Res Public Health. 2019 Oct 18;16(20). pii:
E3974. doi: 10.3390/ijerph16203974.Yokoyama Y, Kitamura A, Yoshizaki
T, Nishi M, Seino S, Taniguchi Y, Amano H, Narita M, Shinkai S. ScoreBased and Nutrient-Derived Dietary Patterns Are Associated with
Depressive Symptoms in Community-Dwelling Older Japanese: A CrossSectional Study. J Nutr Health Aging. 2019;23(9):896-903. doi:
10.1007/s12603-019-1238-2.
22. Yokoyama Y, Kitamura A, Nishi M, Seino S, Taniguchi Y, Amano H, Ikeuchi
T, Shinkai S. Frequency of Balanced-Meal Consumption and Frailty in
Community-Dwelling Older Japanese: A Cross-Sectional Study. J Epidemiol.
2019 Oct 5;29(10):370-376. doi: 10.2188/jea.JE20180076. Epub 2018
Nov 17.
23. Kojima G, Iliffe S, Taniguchi Y, Shimada H, Rakugi H, Walters K. Prevalenceof Frailty in Japan. A Systematic Review and Meta-analysis. J Epidemiol.
2017 Aug;27(8):347-353. doi: 10.1016/j.je.2016.09.008. Epub 2016 Nov
15.
24. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of TNFSF13,SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial

fibrillation by an exome-wide association study. Mol Med Rep. 2017
Nov;16(5):5823-5832. doi: 10.3892/mmr.2017.7334. Epub 2017 Aug 23.
25. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of C21orf59
and ATG2A as novel determinants of renal function-related traits inJapanese by exome-wide association studies. Oncotarget. 2017 Jul
11;8(28):45259-45273. doi: 10.18632/oncotarget.16696.
26. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification ofpolymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic
determinants of blood pressure in Japanese by exome-wide association
studies. Oncotarget. 2017 Jun 27;8(26):43068-43079. doi:
10.18632/oncotarget.17474.
27. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of eight genetic
variants as novel determinants of dyslipidemia in Japanese by exome-wide
association studies. Oncotarget. 2017 Jun 13;8(24):38950-38961. doi:
10.18632/oncotarget.17159.

28. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of rs7350481
at chromosome 11q23.3 as a novel susceptibility locus for metabolic
syndrome in Japanese individuals by an exome-wide association study.
Oncotarget. 2017 Jun 13;8(24):39296-39308. doi:
10.18632/oncotarget.16945.
29. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of six
polymorphisms as novel susceptibility loci for ischemic or hemorrhagic
stroke by exome-wide association studies. Int J Mol Med. 2017
Jun;39(6):1477-1491. doi: 10.3892/ijmm.2017.2972. Epub 2017 May 3.
30. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of STXBP2 as anovel susceptibility locus for myocardial infarction in Japanese individuals
by an exome-wide association study. Oncotarget. 2017 May
16;8(20):33527-33535. doi: 10.18632/oncotarget.16536.
31. Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki
T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S,
Kawai H, Shinkai S, Mori S, Arai T, Tanaka M. Identification of EGFLAM,SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm inJapanese individuals by exome-wide association studies. Int J Mol Med.
2017 May;39(5):1091-1100. doi: 10.3892/ijmm.2017.2927. Epub 2017
Mar 21.
32. Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M,
Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K,
Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M,
Tanaka M. Inverse Association Between Height-Increasing Alleles andExtreme Longevity in Japanese Women. J Gerontol A Biol Sci Med Sci. 2018
Apr 17;73(5):588-595. doi: 10.1093/gerona/glx155.
33. Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Nofuji Y, Narita
M, Matsuo E, Seino S, Kawano Y, Shinkai S. Dietary variety and decline inlean mass and physical performance in community-dwelling older
Japanese: A 4-year follow-up study. J Nutr Health Aging. 2017;21(1):1116. doi: 10.1007/s12603-016-0726-x.
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missense single nucleotide polymorphism, V114I of the Werner syndrome
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Nishi M, Murayama H, Taniguchi Y, Amano H, Takahashi R. Reference
values and age differences in body composition of community-dwellingolder Japanese men and women: A pooled analysis of four cohort studies.
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【その他の共同研究等】

1. 成田美紀, 北村明彦, 武見ゆかり, 横山友里, 森田明美, 新開省二．地域在宅高齢者における食品摂取多様性と栄養素等摂取量，食品群別摂取量及び主食・主菜・副菜を組み合わせた食事日数との関連．日本公衆衛生雑誌．2020, 67(3), 171182.
2. Seino S, Sumi K, Narita M, Yokoyama Y, Ashida K, Kitamura A, Shinkai S.
Effects of low-dose dairy protein plus micronutrient supplementation duringresistance exercise on muscle mass and physical performance in olderadults: A randomized, controlled trial. J Nutr Health Aging. 2018;22(1):5967. doi: 10.1007/s12603-017-0904-5.
3. Nofuji Y, Shinkai S, Taniguchi Y, Amano H, Nishi M, Murayama H, Fujiwara
Y, Suzuki T. Associations of Walking Speed, Grip Strength, and Standing
Balance with Total and Cause-Specific Mortality in a General Population ofolder Japanese. J Am Med Dir Assoc. 2016 Feb;17(2):184.e1-7. doi:
10.1016/j.jamda.2015.11.003. Epub 2015 Dec 21.
4. Shinkai S, Yoshida H, Taniguchi Y, Murayama H, Nishi M, Amano H, Nofuji
Y, Seino S, Fujiwara Y. Public health approach to preventing frailty in thecommunity and its effect on healthy aging in Japan. Geriatr Gerontol Int.
2016 Mar;16 Suppl 1:87-97. doi: 10.1111/ggi.12726.