東京都医学総合研究所年報
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東京都医学総合研究所

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͞ΗΉͲ͹‫ڂݜ‬੔Վն ᚰࡢ೺ᗣ࡙ࡃࡾ㻌 㻌ᑡᏊ㧗㱋໬䚸⤒῭䜔ᩥ໬䛾䜾䝻䞊䝞䝹໬䚸᝟ሗ䜔䝁䝭䝳䝙䜿䞊䝅䝵䞁䛾 㻵㼀 ໬䛿䚸♫఍ᵓ㐀䛸ಶே䛾ព㆑䜢ኚᐜ䛥䛫䚸ᐙᗞ䚸⫋ሙ䚸Ꮫᰯ䚸ᆅᇦ䛾⎔ቃ䛻኱䛝䛺ኚ໬䜢䜒䛯䜙䛧䛶䛔䜛䚹䛭䜜䛻㛵㐃䛧䛶⏕䛨䜛䝇䝖䝺䝇䜔ⴱ⸨䛿䚸ಶே䛾䝯䞁䝍䝹䝦䝹䝇୙ㄪ䛻䛴䛺䛜䜚䜔䛩䛟䚸䝯䞁䝍䝹䜿䜰䛾඘ᐇ䛜ᚲせ䛸䛥䜜䜛䚹ලయⓗၥ㢟䛸䛧䛶䚸䛯䛸䛘䜀⮬ 䖂㻼㼀㻿㻰 デ ᩿ ᑻ ᗘ 䛾㛤 Ⓨ 䛸ᬑ ཬẅ䜔䛖䛴⑓䛾ቑຍ䚸⶝ᘏ䛩䜛⸆≀஘⏝䚸ඣ❺ᛮ᫓ᮇ䛾୙㐺ᛂ䜔ၥ㢟⾜ື䚸ᚰⓗ䝖䝷䜴䝬䛜䜒䛯䜙䛩 㻼㼀㻿㻰 㛵㐃㞀ᐖ䚸ྖἲ⢭⚄་Ꮫⓗㄢ㢟䛸䛧䛶䛾ຍᐖ⾜ື䛾⑓⌮➼ 䖂౫Ꮡ⑕デ᩿ᑻᗘ䛾㛤Ⓨ䛸ᬑཬ䛿䚸᪂䛯䛺䝯䞁䝍䝹䝦䝹䝇䝥䝻䝰䞊䝅䝵䞁䛾䛒䜚᪉䛾◊✲䜢ồ䜑䛶䛔䜛䚹䛭䛾┠ⓗ䛻ྥ䛡䛶䚸䜶䝡䝕䞁䝇䜢㔜ど䛧䛯ᐇドⓗ◊✲ᡭἲ䛻䜘䜚䚸␿Ꮫⓗᐇែ䚸ຠᯝⓗ䛺἞⒪䞉 䖂ᛮ᫓ᮇ䛻䛚䛡䜛኱つᶍ䝁䝩䞊䝖◊✲௓ධ䜔ண㜵ᩍ⫱䛻䛴䛔䛶᫂䜙䛛䛻䛧䚸ᮃ䜎䜜䜛ไᗘ䜔ᨻ⟇䛾ᐇ⌧䛻䜒ᐤ୚䛩䜛䛣䛸䜢┠ᣦ䛩䚹

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յ ᚰࡢ⑓ࡢཎᅉ✲᫂䖂⤫ྜኻㄪ⑕䛾Ⓨ⑕ཎᅉ㑇ఏᏊ䛾Ⓨぢཬྛ✀䛾⢭⚄㞀ᐖ䠄Ẽศ㞀ᐖ䚸୙Ᏻ䞉䝇䝖䝺䝇ᛶ㞀ᐖ䚸⤫ྜኻㄪ⑕䚸≀㉁౫Ꮡ䚸╧╀㞀ᐖ䛺䛹䠅䛻ᑐ䛧䛶䚸㑇ఏᏛⓗ䞉ศᏊ⏕≀Ꮫⓗᡭἲ䛻䜘䜛ཎᅉ✲᫂䛾䛯䜑䛾◊✲䜢 䜃἞⒪⸆䛾㛤Ⓨ㐍ᒎ䛥䛫䜛䚹ྛ⑓ែ䛻䛚䛔䛶䚸㑇ఏᏊከᆺ䜔ೃ⿵㑇ఏᏊ䞉㛵㐃㑇ఏᏊ䛾ゎᯒ䚸Ṛᚋ⬻䜔⏕యヨᩱ䜢⏝䛔䛯⏕໬Ꮫⓗゎᯒ䚸⏕≀Ꮫⓗ⬤ᙅᛶ䛻㛵䛩䜛ศᏊ䞉⣽⬊䝺䝧䝹 䖂㑇ఏᏊゎᯒ䛻䜘䜛⸆≀ឤཷᛶண ἲ䛾㛤䛾ゎᯒ䚸㑇ఏᏊᨵኚ䝬䜴䝇䜢⏝䛔䛯⾜ື䝺䝧䝹䛾ゎᯒ䛺䛹䛻䜘䜚䚸ཎᅉཬ䜃ᇶ♏䝯䜹䝙䝈䝮䜢ゎ᫂䛩䜛䚹䛒䜟䛫䛶⬻Ἴ䜔⮬ᚊ⚄⤒άື䛺䛹䛾⢭⚄⏕⌮Ꮫⓗᣦᶆ䛾ศ Ⓨᯒ䜔䚸䝙䝳䞊䝻䜲䝯䞊䝆䞁䜾ᡭἲ䛻䜘䜛⑓ែゎ᫂䛚䜘䜃἞⒪ᣦᶆ䜔᪩ᮇデ᩿䛻ᙺ❧䛴◊✲䜢㐍䜑䜛䚹䛥䜙䛻᪂つ⸆๣䛾㛤Ⓨ䜔䚸⑓ែ䛻ᙳ㡪䛩䜛ᰤ㣴⣲䛾◊✲䚸ື≀䝰 䖂㐣╀⑕䛾⑓ែ䛻㛵୚䛩䜛㑇ఏᏊ䛾Ⓨぢ䝕䝹䛻䜘䜛ೃ⿵἞⒪⸆ᶆⓗศᏊ䛾స⏝ᶵᗎ䛾ゎᯒ䛺䛹䜢㏻䛨䛶䚸䜸䞊䝎䞊䝯䜲䝗䛾἞⒪ἲ䜔ண㜵ἲ䛾ᐇ⌧䜢┠ᣦ䛩䚹

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䖂䝟䞊䜻䞁䝋䞁⑓䛻䛚䛡䜛⣽⬊Ṛ㜼Ṇἲ䛾㛤䜰䝹䝒䝝䜲䝬䞊⑓䜔䝟䞊䜻䞁䝋䞁⑓䚸䝺䝡䞊ᑠయᆺㄆ▱⑕䠄㻰㻸㻮䠅䚸๓㢌ഃ㢌ⴥኚᛶ⑕䠄㻲㼀㻸㻰䠅䚸➽ⴎ⦰ᛶഃ⣴◳໬⑕䠄㻭㻸㻿䠅䚸ከ⣔⤫ⴎ⦰⑕䚸⬨㧊ᑠ⬻ኚᛶ⑕➼䛷⵳ Ⓨ✚䛩䜛␗ᖖ⺮ⓑ㉁䠄䝍䜴䚸䃐 䝅䝚䜽䝺䜲䞁䚸㼀㻰㻼㻙㻠㻟䚸䝫䝸䜾䝹䝍䝭䞁➼䠅䛾Ⓨ⌧ᶵᗎ䛸⚄⤒⣽⬊ኚᛶ㐣⛬䛾ゎ᫂䛻䜘䜚䚸䛣䜜䜙ㄆ▱⑕⑌ᝈ䜔ᡂேᮇ⚄⤒㞴⑓䛾デ᩿ἲ䞉἞ 䖂䃑䜰䝭䝻䜲䝗䛻ᑐ䛩䜛 㻰㻺㻭 䝽䜽䝏䞁䛾㛤Ⓨ⒪ἲ䛾㛤Ⓨ䜢⾜䛖䚹≉䛻䜰䝹䝒䝝䜲䝬䞊⑓⬻䜈䛾䜰䝭䝻䜲䝗 䃑 ⺮ⓑ㉁⵳✚䜢ῶᑡ䛥䛫䜛 㻰㻺㻭 䝽䜽䝏䞁䛾ᐇ⏝໬䜢᥎㐍䛩䜛䚹䛥䜙䛻䚸ከᵝ䛺⚄⤒㞴⑓䜔ᵝ䚻䛺ཎᅉ䛻㉳ 䖂ㄆ▱⑕䛸 㻭㻸㻿 䛻ඹ㏻䛩䜛ཎᅉ⺮ⓑ㉁␗ᖖ
ᅉ䛩䜛ᮎᲈ⚄⤒㞀ᐖ䛻䛴䛔䛶䚸䝠䝖䛾⬻⚄⤒⣔䛾ゎᯒ䛸ື≀䞉⣽⬊䝰䝕䝹䛾ゎᯒ䛸䜢⼥ྜ䛧䛶㐍䜑䚸䛭䛾⑓ᅉ䞉⑓ែ䜢᫂䜙䛛䛻䛧䛶἞⒪ἲ䛾㛤Ⓨ䛻⤖䜃䛴䛡䜛䚹䜢Ⓨぢ䛧䚸⑓ែ䜢ゎ᫂ճ ㄆ▱⑕࡜⚄⤒㞴⑓䖂ᐟ୺ᅉᏊ䜢ᶆⓗ䛻䛧䛯ᢠ 㻯 ᆺ⫢⅖䜴䜲䝹᪂⯆ཬ䜃㞴἞ᛶ䜴䜲䝹䝇ឤᰁ⑕䛾ண㜵䛻᭷ຠ䛺䝽䜽䝏䞁䜔᪂䛯䛺἞⒪ἲ䛾☜❧䜢┠ᣦ䛩䚹᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛻ᑐ䛧䛶䝥䝺䝟䞁䝕䝭䝑䜽୙ά໬䝽䜽䝏䞁䛜ഛ 䝇๣䛾㛤Ⓨ␆䛥䜜䛶䛔䜛䚹䛧䛛䛧䚸ὶ⾜ᰴ䛜ண 䛷䛝䛺䛔䛣䛸䚸᥋✀ᚋຠᯝ䛜ฟ䜛䜎䛷㛗ᮇ㛫䛛䛛䜛䛣䛸䛜ၥ㢟ど䛥䜜䛶䛔䜛䚹䛭䛣䛷䚸༢ᅇ᥋✀䞉▷ᮇ㛫䛷䜒᭷ຠ䛺⤌᥮䛘⏕䝽䜽䝏 䖂㻯 ᆺ⫢◳ኚ἞⒪⸆䛾㛤Ⓨ䞁➼䛻䜘䜛ண㜵ἲ䛾☜❧䜢┠ᣦ䛩䚹䜎䛯䚸㻯 ᆺ⫢⅖䜴䜲䝹䝇䚸㻮 ᆺ⫢⅖䜴䜲䝹䝇➼ᣢ⥆ឤᰁ໬䛩䜛䜴䜲䝹䝇⑌ᝈ䛾἞⒪䛿ᅔ㞴䛷䛒䜛䚹䜴䜲䝹䝇」〇䜢ᢚไ䛩䜛᰾㓟䜰 䖂᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ண㜵䝽䜽䝏䞁䛾㛤Ⓨ䝘䝻䜾䜔䝥䝻䝔䜰䞊䝊㜼ᐖ๣➼䛜἞⒪䛻⏝䛔䜙䜜䛶䛔䜛䛜䚸⸆๣⪏ᛶ䜴䜲䝹䝇䛜ฟ⌧䛧᫆䛟䚸⤊⏕ᢞ⸆἞⒪䛜ᚲせ䛷䛒䜛䚹䛭䛣䛷䚸ᐟ୺ᅉᏊ䜢ᶆⓗ䛻䛧䛯ᢠ䜴䜲䝹䝇๣ 䖂䝕䞁䜾⇕ண㜵䝽䜽䝏䞁䛾㛤Ⓨ䛸ච␿䛻䜘䜛᤼㝖⣔䛾ᙉຊ䛺άᛶ໬䜢䜒䛯䜙䛩䛣䛸䛷䚸䛣䜜䜙᰿἞ᅔ㞴䛺䜴䜲䝹䝇⑌ᝈ䛾᏶඲䛺⑓ែไᚚ䜢┠ᣦ䛩䚹䖂᪂ᆺ䝁䝻䝘䜴䜲䝹䝇ឤᰁ⑕ண㜵䝽䜽䝏䞁䛾㛤Ⓨղ ឤᰁ⑕ࡢඞ᭹

䖂䝀䝜䝮䛾Ᏻᐃ䛺⥔ᣢ䚸ఏᦙ䛸Ⓨ䛜䜣䛾䝯䜹䛜䜣⣽⬊䛾䝀䝜䝮䛿䛂୙Ᏻᐃ䛃䛷䛒䜚ከ䛟䛾ኚ␗䚸㑇ఏᏊ␗ᖖ䜢⵳✚䛧䛶䛔䜛䚹䝀䝜䝮୙Ᏻᐃᛶ䛿䚸ᰁⰍయ䛾」〇䜔ಟ᚟䚸ศ㓄䛺䛹䜢ᢸ䛖ᶵ⬟䛾␗ᖖ䛸῝䛟㛵㐃䛩䜛䚹䝙䝈䝮䛾ゎ᫂
ᮏ◊✲ㄢ㢟䛷䛿䚸ᰁⰍయ䞉䝀䝜䝮䛾ୡ௦䜢㏻䛨䛯Ᏻᐃ䛺⥔ᣢ䚸⥅ᢎ䛾䝯䜹䝙䝈䝮䚸䛭䛾୙඲䛜䜒䛯䜙䛩⣽⬊䝺䝧䝹䚸ಶయ䝺䝧䝹䛷䛾␗ᖖ䜢ゎ᫂䛩䜛䛸䛸䜒䛻䚸✀䚻䛾䛜䜣䖂䛜䜣䝞䜲䜸䝬䞊䜹䞊䛾᥈⣴䛸㎿㏿䛺デ᩿⣽⬊䚸⭘⒆䛾䝀䝜䝮䚸䜶䝢䝀䝜䝮䝺䝧䝹䛷䛾ኚ໬䚸㑇ఏⓗ≉ᛶ䚸䛒䜛䛔䛿␗ᖖቑṪ䛾ᇶ┙䛸䛺䜛⣽⬊࿘ᮇ䞉ᰁⰍయ䝃䜲䜽䝹ไᚚ␗ᖖ䜢ゎ᫂䛩䜛䚹䛣䜜䜙䛾▱ぢ䛿䚸䛜䜣ἲ䛾㛤Ⓨᚁᅽ䛾䛯䜑䛾᪂䛧䛔ศᏊᶆⓗ䛾Ⓨぢ䜢䜒䛯䜙䛩䛸䛸䜒䛻䚸䛜䜣䛾䝍䜲䝥䛻ᇶ䛵䛔䛯ಶู἞⒪ἲ䛾㛤Ⓨ䛾ᇶ┙䛸䜒䛺䜛䚹䛜䜣䛾᧞⁛䛾䛯䜑䛻䛿䚸ண㜵䚸᪩ᮇⓎぢ䛜䛝䜟䜑䖂⑊③἞⒪䛻䛚䛡䜛㙠③⸆ឤཷᛶண 䝅䝇䛶㔜せ䛷䛒䜛䚹䛭䜜䛸䛸䜒䛻䚸䛜䜣ᝈ⪅䛾ⱞ③䜢㍍ῶ䛩䜛἞⒪䜒ᮃ䜎䜜䜛䚹䛣䛾䛯䜑䛻ᮏ◊✲ㄢ㢟䛷䛿䚸✀䚻䛾䛜䜣⣽⬊䚸⭘⒆䛻䛚䛡䜛䝞䜲䜸䝬䞊䜹䞊䛾ྠᐃ䛸⡆౽䚸䝔䝮䛾㛤Ⓨ㎿㏿䛺᪩ᮇデ᩿ἲ䛾㛤Ⓨ䜒┠ᣦ䛧䚸䛜䜣䛾᪩ᮇⓎぢ䈄἞⒪ཬ䜃䛜䜣ᛶ⑊③䛾἞⒪䛾᪂䛯䛺ᡓ␎䜢ぢฟ䛩䚹ձ ࢤࣀ࣒࡜ࡀࢇ

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͞ΗΉͲ͹‫ڂݜ‬੔Վே䛾⾜ື䜢䝝䞊䝗䜴䜵䜰ⓗ䛻ᨭ䛘䜛㐠ື䝅䝇䝔䝮䠄㐠ື⓶㉁㐃ྜ㔝䚸ᇶᗏ᰾䚸ᑠ⬻䚸⬻ᖿ䞉⬨㧊䛾㐠ື⚄⤒᰾䚸ᮎᲈ⚄⤒䞉➽䠅䚸䛚䜘䜃ឤぬ䝅䝇䝔䝮䠄どぬ䞉⫈ぬ䞉࿡ 䖂㝶ព㐠ື᫬䛻䛚䛡䜛⬨㧊䛾㐠ືไᚚᶵᵓぬ䞉Ⴅぬ䞉యᛶឤぬ䠅䜢䝅䝇䝔䝮䝺䝧䝹䛛䜙ศᏊ䝺䝧䝹䜎䛷䛾ከᒙⓗ䞉」ྜⓗ䜰䝥䝻䞊䝏䛷◊✲䛧䚸䛭䛾ᶵ⬟㞀ᐖ䛾ඞ᭹䜢ᅗ䜛䚹≉䛻䚸኱⬻䠉ᑠ⬻䠉ᇶᗏ᰾㐃㛵䛻䛚䛡 䛾ゎᯒ䜛᝟ሗฎ⌮ᶵᵓ䜢ゎ᫂䛩䜛◊✲䜢᥎㐍䛧䚸㐠ືኻㄪ䜢䛝䛯䛩⑌ᝈ䠄䝟䞊䜻䞁䝋䞁⑓䚸⬨㧊ᑠ⬻ኚᛶ⑕䛺䛹䠅䛷ぢ䜙䜜䜛㐠ື䝅䝇䝔䝮␗ᖖ䛾⑓ែゎ᫂䜔἞⒪ἲ㛤Ⓨ䜢┠ 䖂୙㝶ព㐠ື䛾⚄⤒ᅇ㊰ᶵ⬟䛾ゎ᫂ᣦ䛩䚹䜎䛯䚸⬻⾑⟶㞀ᐖ䚸⬻⬨㧊ᦆയ䚸⢾ᒀ⑓䜔㑇ఏᛶ䝙䝳䞊䝻䝟䝏䞊䚸⚄⤒⅖䛺䛹䛾ᮎᲈ⚄⤒㞀ᐖ䚸➽⑌ᝈ䚸どᶵ⬟㞀ᐖ䛺䛹䛾⑓ែ䚸䛚䜘䜃䝨䜲䞁䝁䞁䝖䝻䞊䝹䜔ឤ 䖂ṇᖖ║ᅽ⥳ෆ㞀䛾Ⓨ⑕䝯䜹䝙䝈䝮䛾ゎ᫂ぬᶵᵓ䛾ゎ᫂䛾䛯䜑䛾◊✲䜢⾜䛖䚹䛭䜜䜙䛻䜘䜚䚸㑇ఏᏊ἞⒪䜔⣽⬊⛣᳜἞⒪䚸䝤䝺䜲䞁䝬䝅䞁䜲䞁䝍䞊䝣䜵䞊䝇䜢㥑౑䛧䛯䝃䜲䝞䞊་⒪➼䛾㠉᪂ⓗ་⒪䛾ᐇ⏝໬䛻䜒✚ᴟⓗ䛻ྲྀ䜚⤌䜣䛷䛔䛟䚹ռ 㐠ືឤぬᶵ⬟࡜ࡑࡢ␗ᖖ

䖂⚄⤒ẘ䜢฼⏝䛩䜛䝅䝘䝥䝇ఏ㐩ᶵ⬟䛾ゎே䛜෇⁥䛺♫఍⾜ື䜢㐙⾜䛩䜛䛯䜑䛻Ḟ䛟䛣䛸䛾䛷䛝䛺䛔㧗ḟ⬻ᶵ⬟䠄ㄆ▱ᶵ⬟䚸⤫ྜ䞉㐃ྜᶵ⬟䚸᝟ືᶵ⬟䚸⾜ືไᚚᶵᵓ䛺䛹䠅䛻䛴䛔䛶⏕⌮Ꮫⓗ䚸ゎ๗Ꮫⓗ䚸䛚 ᫂䜘䜃ศᏊ⏕≀Ꮫⓗᡭἲ䛻䜘䜚䝯䜹䝙䝈䝮ゎ᫂䛾◊✲䜢⾜䛖䚹䛭䛧䛶䚸⬻༞୰䞉⬻እയ䞉䛶䜣䛛䜣䜢䛿䛨䜑ᵝ䚻䛺ཎᅉ䛻䜘䛳䛶㉳䛣䜛㧗ḟ⬻ᶵ⬟㞀ᐖ䠄Ꮫ⩦䞉グ᠈㞀ᐖ䚸ὀ 䖂ពḧ䜔ືᶵ௜䛡䛾⬻ෆ䝯䜹䝙䝈䝮䛾ゎ᫂ព㞀ᐖ䚸㐙⾜ᶵ⬟㞀ᐖ䚸♫఍ⓗ⾜ື㞀ᐖ䚸ኻㄒ⑕䛺䛹䠅䛾⑓ែゎ᫂䛚䜘䜃⬻ᶵ⬟㞀ᐖ䛾἞⒪ἲ䛾㛤Ⓨ䛾䛯䜑䛾◊✲䜢᥎㐍䛩䜛䚹䜎䛯䚸኱⬻䜢୰ᚰ䛸䛧䛯ྛ㧗ḟ⬻ᶵ⬟ 䖂グ᠈㞀ᐖ䛻㛵୚䛩䜛㑇ఏᏊ䛾Ⓨぢ䛾䝅䝇䝔䝮ⓗゎᯒ䛻ຍ䛘䛶䚸⚄⤒⣽⬊㛫䛾ఏ㐩ᶵᵓ䚸⣽⬊ෆศᏊᶵᵓ䛾ゎᯒ䚸ᶵ⬟㑇ఏᏊཬ䜃⾜ື㑇ఏᏛⓗゎᯒ䜢⾜䛖䚹⬻⾑ὶ䜔䜶䝛䝹䜼䞊௦ㅰ䜢ᣦᶆ䛻䛧䛯䚸⬻ 䖂᪂䛧䛔⬻άືィ ἲ䛾㛤Ⓨᶵ⬟䜢⏬ീ໬䛩䜛᪂䛧䛔ᢏ⾡䜢ᛂ⏝䛧䛶䚸᪂つⓗ䛺デ᩿䞉἞⒪ἲ䛾㛤Ⓨ䛾䛯䜑䛾◊✲䜒㐍䜑䜛䚹ջ 㧗ḟ⬻ᶵ⬟࡜ࡑࡢ␗ᖖպ ⑌⑓ࡢ㑇ఏᏛ䖂ᶆⓗ⣽⬊䝜䝑䜽䜰䜴䝖䠄㼀㻾㻱㻯㻷䠅ἲ䛻䜘䜛䝠䝖⑌ᮏ◊✲ㄢ㢟䛿䚸䝠䝖䛾⑌ᝈ䛸䛭䛾㈐௵㑇ఏᏊ䛸䛾┦஫㛵ಀ䜢㑇ఏᏛⓗᡭἲ䛻䜘䜚ゎ᫂䛧䚸⑌⑓䛾ཎᅉ✲᫂䜔䛭䜜䜢ᇶ♏䛸䛧䛯᪂つ἞⒪ἲ䛾㛤Ⓨ䛻䛴䛺䛢䜛䛣䛸䜢┠ ᝈ䝰䝕䝹䝬䜴䝇䛾సฟⓗ䛸䛧䛶䛔䜛䚹᪉ἲ䛿௨ୗ䛾 㻞 䛴䛷䛒䜛䚹➨ 㻝 䛿䚸䝠䝖⑌ᝈ䚸䛒䜛䛔䛿䝠䝖⑌ᝈ䝰䝕䝹ື≀䛾ከᵝ䛺⾲⌧ᆺ䜢ᨭ㓄䛩䜛㈐௵㑇ఏᏊ䜢ྠᐃ䛧䚸䛭䛾㑇ఏᏊ䛾ᵓ㐀䛸ᶵ⬟䛛 䖂䝠䝖⑌ᝈ䝰䝕䝹䝬䜴䝇䜢⏝䛔䛯㞴⫈䚸ⓑෆ㞀䜙䚸⑓Ẽ䛾ཎᅉ䜢᫂䜙䛛䛻䛧䛶䛔䛟㑇ఏᏛⓗ᪉ἲ䛷䛒䜛䚹➨ 㻞 䛿ೃ⿵㈐௵㑇ఏᏊ䜢⏝䛔䛶㑇ఏᏊᨵኚ䝬䜴䝇䜢సฟ䛧䚸≉ᐃ䛾㑇ఏᏊ䛾ᶵ⬟䛜⑌⑓Ⓨ⑕䛸ᑐᛂ䛩䜛䛛䛹 ཎᅉ㑇ఏᏊ䛾✲᫂䛖䛛䜢᳨ド䛩䜛㏫㑇ఏᏛⓗ᪉ἲ䛷䛒䜛䚹䛣䜜䜙䛾◊✲䛾⤖ᯝ䚸ᶞ❧䛥䜜䛯䝠䝖⑌ᝈ䝰䝕䝹ື≀䛿䚸᭷⏝䛺䝸䝃䞊䝏䝒䞊䝹䛸䛧䛶䚸ᶆⓗ䛸䛺䜛ᵝ䚻䛺⑌⑓䛾἞⒪ἲ䜔ண㜵 䖂䝭䝖䝁䞁䝗䝸䜰⑓◊✲䛾䛯䜑䛾䝭䝖䝁䞁䝗䝸䜰ྍど໬䝬䜴䝇ἲ䛾㛤Ⓨ䛻ᙺ❧䛴䚹䖂䜰䝖䝢䞊ᛶ⓶⭵⅖䝰䝕䝹䛸䛧䛶䛾↓ẟ໬䝬䜴䝇䖂䜰䝺䝹䜼䞊䝬䜴䝇䛾సฟ䚸䛺䜙䜃䛻䜰䝺䝹ⰼ⢊⑕䞉Ẽ⟶ᨭႍᜥ䞉䜰䝖䝢䞊ᛶ⓶⭵⅖䛿䚸㒔ෆ䛷䜒ᝈ⪅ᩘ䛾ከ䛔⑌ᝈ䛷䛒䜛䚹䜎䛯䚸Ḣ⡿ᆺ䛾㣗⏕ά䛻䜘䜛䝯䝍䝪䝸䝑䜽⑕ೃ⩌䜒ᖺ䚻῝้໬䛧䛶䛔䜛䚹䛣䛾䜘䛖䛺䜰䝺 䜼䞊㈐௵⣽⬊䛾Ⓨぢ䝹䜼䞊ᛶ⑌ᝈ䜔⏕ά⩦័⑓䛿䚸㼀 ⣽⬊䚸⫧‶⣽⬊䚸⬡⫫⣽⬊➼䛾ㄪ⠇␗ᖖ䛻㉳ᅉ䛩䜛䛯䜑䚸䜎䛪㈐௵⣽⬊䛾ቑṪ䞉ศ໬䞉ືဨ䛾ศᏊᶵᵓ䜢᫂䜙䛛䛻䛩䜛ᚲせ䛜䛒䜛䚹 䖂ⰼ⢊⑕䜢㍍ῶ䛥䛫䜛᪂䛧䛔἞⒪ἲ䛾◊✲୍᪉䚸ෆⓗせᅉ䛻䜘䛳䛶䛚䛣䜛⮬ᕫච␿⑌ᝈ䚸௦ㅰ␗ᖖ䚸㞴἞ᛶ⮚ჾኚᛶ⑌ᝈ䛾౛䜒ከ䛔䚹䛣䜜䜙䜢ඞ᭹䛩䜛䛻䛿䚸◚⥢䛧䛯⣽⬊ᶵ⬟䛸㈐௵ศᏊ䛸䜢ྠᐃ䛧䚸䛣䜜䜙䜢 䖂⫧‶ᛶ⢾ᒀ⑓䛾ᝏ໬ᅉᏊ䜿䝰䜹䜲䞁⸆≀ᢞ୚䜔⣽⬊⛣᳜䛻䜘䛳䛶ṇᖖ໬䛥䛫䛺䛡䜜䜀䛺䜙䛺䛔䚹⤌⧊ᖿ⣽⬊䜔 㼕㻼㻿 ⣽⬊䜢⏝䛔䛯෌⏕་⒪ἲ䜒⪃៖䛥䜜䜛䜉䛝䛷䛒䜛䚹ᮏ◊✲ㄢ㢟䛷䛿䚸⏕య㜵ᚚ䛾䝯䜹䝙 㻯㼄㻯㻸㻝㻠 䛾ゎ᫂䝈䝮䜢ಶయ䞉⣽⬊䞉ศᏊ䝺䝧䝹䛷◊✲䛧䚸䛭䜜䜙䛾◚⥢䛻㉳ᅉ䛩䜛ྛ✀⑌ᝈ䛾἞⒪ἲ䞉ண㜵ἲ䛾㛤Ⓨ䜢┠ᣦ䛩䚹չ ⏕య㜵ᚚࡢ࣓࢝ࢽࢬ࣒

䖂⣽⬊ᛶච␿䛻䛚䛡䜛䝥䝻䝔䜰䝋䞊䝮䛾ᙺ
⺮ⓑ㉁䛿⣽⬊䛾ቑṪ䜔ศ໬䛺䛹⏕࿨άື䛾ᇶ┙䜢ྖ䛳䛶䛚䜚䚸㓝⣲䚸⣽⬊㦵᱁䚸㌿෗ᅉᏊ䚸ཷᐜయ䛺䛹ከ✀ከᵝ䛺ᶵ⬟䜢ᣢ䛴䚹ᚑ䛳䛶⺮ⓑ㉁䛾◚⥢䛿䚸ᝏᛶ⭘⒆䚸 ๭䛾ゎ᫂䝯䝍䝪䝸䝑䜽⑕ೃ⩌䚸⮬ᕫච␿⑌ᝈ䚸➽⑌ᝈ䚸⚄⤒ኚᛶ⑌ᝈ䛺䛹ᵝ䚻䛺⑓ែ䜢ᘬ䛝㉳䛣䛩䚹⑌ᝈ䛾デ᩿䞉἞⒪䞉ண㜵䛾䛯䜑䛻䛿䚸䛣䜜䜙⺮ⓑ㉁䛾ᵓ㐀䛸ᶵ⬟䜢ศᏊ䝺䝧䝹 䖂䝥䝻䝔䜰䝋䞊䝮䛻䜘䜛䝍䞁䝟䜽㉁ศゎ⤒㊰䛷ゎ᫂䛧䚸⺮ⓑ㉁䛾ᶵ⬟୙඲䛻䜘䜛⑓ែⓎ⑕ᶵᗎ䛾ศᏊ䝯䜹䝙䝈䝮䜢᫂☜䛻䛩䜛䛣䛸䛜ᴟ䜑䛶㔜せ䛷䛒䜛䚹඲䛶䛾⺮ⓑ㉁䛿༓ᕪ୓ู䛾ᑑ࿨䜢䜒䛳䛶䝍䞊䞁䜸䞊䝞䞊䛧 䛾ゎ᫂䛶䛚䜚䚸䛭䛾㛫䛻䝸䞁㓟໬䚸䝴䝡䜻䝏䞁໬䚸䝨䝥䝏䝗㙐ษ᩿䚸䛺䛹ᶵ⬟ኚ᥮䛾䛯䜑䛾ᵝ䚻䛺⩻ヂᚋಟ㣭䜢ཷ䛡䜛䚹䛧䛛䛧䚸⺮ⓑ㉁䛾௦ㅰ䝅䝇䝔䝮䚸⢾䞉⬡㉁䛾ྜᡂ䞉ศゎ䛻 䖂⚄⤒⣽⬊䛾⮬㣗స⏝䛜䚸⚄⤒ኚᛶ⑌ᝈ㛵୚䛩䜛㓝⣲ᶵ⬟䚸䛥䜙䛻䚸⺮ⓑ㉁䛸௚䛾⏕యศᏊ䛸䛾┦஫స⏝䛻䜘䜛᝟ሗఏ㐩䛾䝯䜹䝙䝈䝮䛺䛹⺮ⓑ㉁䛾స⏝䛾኱㒊ศ䛜ᮍ▱䛾䜎䜎䛷䛒䜛䚹䛭䛣䛷ᮏ◊✲ㄢ㢟䛷 䛾Ⓨ⑕䜢㣗䛔Ṇ䜑䜛䛿䚸⏕໬Ꮫ䚸䝥䝻䝔䜸䞊䝮䚸ศᏊ⏕≀Ꮫ䚸⣽⬊⏕≀Ꮫ䚸ᵓ㐀⏕≀Ꮫ䚸㑇ఏᏛ䛺䛹䛾᭱ඛ➃ᢏ⾡䜢㥑౑䛧䛶䚸⺮ⓑ㉁䛜⏕࿨άື䛻䛚䛔䛶ᯝ䛯䛩ᙺ๭䜢ゎ᫂䛧䚸䛭䛾సື 䖂⤌⧊≉␗ⓗ䜹䝹䝟䜲䞁䛾᪂䛧䛔స⏝ᶵᗎ䛾Ⓨぢཎ⌮䛻㛵䛩䜛᪂䛧䛔ᴫᛕ䛾๰ᡂ䜢┠ᣦ䛩䚹ո ⺮ⓑ㉁ࡢ௦ㅰ࡜⑌⑓

䖂㻭㻸㻿 䛾ᅾᏯேᕤ࿧྾ჾ⒪ἲ䛾☜❧䛸ไᗘ⬻⾑⟶㞀ᐖ䚸䛜䜣䚸⚄⤒䞉➽⑌ᝈ䚸⢭⚄⑌ᝈ䛻క䛖ṧ㑇⑕≧䜔ᶵ⬟㞀ᐖ䜢ཎᅉ䛸䛧䛯೺ᗣၥ㢟䜔᪥ᖖ⏕ά䛾ᨭ㞀䜢㍍ῶ䛩䜛䛣䛸䛿䚸㞀ᐖ䛻ⱞ䛧䜐ே䚻䛾䠭䠫䠨䠄⏕ά ໬䜈䛾㈉⊩䛾㉁䠅䛾ྥୖ䛻䛸䛳䛶ᚲ㡲䛷䛒䜛䚹䛣䛾◊✲ㄢ㢟䛷䛿䚸䛭䛾┠ⓗ䛻ྥ䛡䛶䚸䜘䜚䜘䛔┳ㆤ䞉௓ㆤἲ䚸䝸䝝䝡䝸ἲ䚸௦᭰ἲ䜔⦆࿴䜿䜰ἲ䛾㛤Ⓨ䜢┠ᣦ䛩◊✲䜢᥎㐍䛩䜛䚹䛺 䖂኱⬻༙⌫ᦆയᚋ䛾㧗ḟ⬻ᶵ⬟㞀ᐖ䛾デ䛛䛷䜒䚸㠀౵くⓗேᕤ࿧྾ἲ䠄㻺㻼㻼㼂䠅䛺䛹⒪㣴⪅䛸௓ㆤ⪅䛻㈇ᢸ䛜ᑡ䛺䛟Ᏻ඲䛺┳ㆤᨭ᥼ἲ䜔ᅾᏯ་⒪⟶⌮ἲ䛾㛤Ⓨ䚸ᆅᇦ䛷⏕ά䜢Ⴀ䜐㞀ᐖ⪅䛾♫఍᚟ᖐ䡡♫఍ཧ ᩿ἲ䛾☜❧ຍ䛾ᨭ᥼䛾඘ᐇ䚸ಖ೺䞉་⒪䞉⚟♴䛜㐃ᦠ䛧䛯㈝⏝ᑐຠᯝ䛾㧗䛔䝃䞊䝡䝇ᥦ౪యไ䛾☜❧䛺䛹䜢┠ᣦ䛧䛯◊✲䜢ᒎ㛤䛩䜛䚹䜎䛯䚸ᑓ㛛་⒪ᶵ㛵䛸㐃ᦠ䛧䛶䚸ᐈほⓗ䛺 䖂➽άື䛾ᐃ㔞ⓗゎᯒ䛻䜘䜛㐠ືᶵ⬟ホ౯ᣦᶆ䛻ᇶ䛵䛟┳ㆤ䞉௓ㆤ䛾ホ౯䝅䝇䝔䝮䜢⏝䛔䛯ᐇドⓗ䛺ㄪᰝ◊✲䜢⾜䛖䚹䛥䜙䛻䚸㧗ḟ⬻ᶵ⬟䚸㐠ື䞉ឤぬ䝅䝇䝔䝮䚸⢭⚄⑌ᝈ⑓ែ➼䛻㛵䛩䜛⚄⤒⛉Ꮫ◊✲䛛䜙ᚓ䜙 ἲ䛾㛤Ⓨ䜜䛯᪂▱ぢ䜢䝸䝝䝡䝸䝔䞊䝅䝵䞁䛾⌧ሙ䛷ά⏝䛩䜛䛯䜑䛾᪂䛧䛔⿦⨨䜔ᡭἲ㛤Ⓨ䛾◊✲䜢᥎㐍䛩䜛䚹䖂ㄆ▱⑕䜿䜰䝥䝻䜾䝷䝮䛾㛤Ⓨཬ䜃ᬑཬշ ┳ㆤ㺃௓ㆤࢣ࢔࡜ࣜࣁࣅࣜ

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峵岞岽島峳峘ଡୗ峮଻‫ر‬峘ૌங峕ঢ়ଖ峃峵౤৕峙岝୭୆峒峘ৼ൩੿৷峕峬ൂ 崚崶嵈峘ಲഅ峕ঢ়ଖ峃峵ற෷崟崘崲嵓峒਑౪౤ோ峁峐૗৲峁岝崚崶嵈૗৿峼峬峉峳峁岝岶峽峼அ峪ர‫ر‬峘ႈ೩峘ਉ౤峒峬峔峵岞৕岝峇島峳峘଻৬৅ে嵣ী৲峕岴岻峵ਃચ峼ੰ৥

3- റู‫ط‬3- ஶୁ੡റู
嵒嵤崨嵤੡

‫ڭ‬ম崿嵕崠崏崗崰峑峙岝崚崶嵈೐੅嵣ಲഅ峕ঢ়ଖ峃峵崚崶嵈嵣ഉ౦৬峘੗஘峔ଡ

*HQRPH'\QDPLFV3URMHFWୗ峮਑౪౤৕峘ে৶৓ਔଝ峼ੰ৥峃峵岞岽峘ଢ଼஢峘ਛટ峙岝崚崶嵈૗৿岶 ୭୆౤৕峕峲峵崚崶嵈૗৿峘ා଑峒ႈ೩৅ে峘ਫ੩୲௟峬峉峳峃ႈ೩峘৅েਃ๰峼ੰ৥峁岝ৗૠ峘൧૵岝੘௜১峘৫৅峕峎峔岼峵岞ী৕ਃଡ峼ੰ৥峁岝ৗ峁岮੘௜ਅറ峼ੁ৒峃峵ଡ峘ੰ৥୔ല 3-'HDIQHVV3URMHFW୺ਆᆜ࿜崓嵓崹崌嵛峕峲峵ে৬ਃચ೐
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‫گ‬峃峵崚崶嵈৿ଙ 3-୔ല峘఩஫৓ਏ౤峒৅ඪਃ‫ڮ‬਍৒೐੅峘ী৕੦ೕ峼ੰ৥峃峵୔ല峼峬峎ৗেు峙৺  য峕  য峘સ়峑ไে峁岝峨峉ਸೡ峕峲峴᡺೩૨岶঱ಊ峃峵岞୔ല೩঻峘৺઄ਯ峙఩஫৓ਏ౤峕峲峴৅ඪ峃峵岽峒岵峳岝൧૵岝੒ଆ岴峲峝੘௜১峘નয়峘峉峫峕峙岝ਉ౤峒峔峵఩஫৕峘৊৒岴峲峝ਃચੰ৥岶૶ਜ峑岬峵岞峨峉岝୔ല峙ႇႌ୰岝ৈഷಓඪ峔峓౎峘ႈ೩岶৅ඪ嵒崡崗峒峔峵岽峒岝঳্峑岝ੳੴඪ岝ੱ৶঺ভ৓ႈ೩峙୔ല岶৅ඪ嵒崡崗峒峔峵岽峒岵峳岝୔ല峒ঢ়৴ႈ೩峒峘౤ટঢ়બ峼ੰ৥峃峵岽峒峙੎ਏ峔ୖ਻峑岬峵岞 ੔ଠਙ岝ਸೡਙ岴峲峝๱ఠਙ୔ല峘৅ඪ峕ঢ়ଖ峃峵఩஫৕峼৊৒峁岝ਃચ峼ੰ৥峃峵 ୔ല嵊崯嵓৿੟峼৷岮峐୔ല峒౎峘ႈ೩峒峘౤ટঢ়બ峼৥峳岵峕峃峵 ৗ峉峔୔ല嵊崯嵓৿੟峘৫৅岝୔ല੒ଆ嵣੘௜১峘નয়峼৯੐峃崓嵓崹崌嵛峙಍ཝ৔峘ᐨஜସীੰᇪಞ‫ق‬崿嵕崮崊嵤崤‫ك‬峑岬峴岝஘‫ر‬峔੦ 崓嵓崹崌嵛峕峲峵੦ସ崧嵛崹崗ସীੰ岶૑ਏ峔ে৶ସᐨஜସ峕ৌ峃峵੎ਏ峔嵊崠嵍嵔嵤崧嵤峒峁峐ਃચ峃峵岞峇峘峉峫岝崓嵓崹崌嵛ણਠ଴峼્৒峁岝崓嵓崹崌嵛ણਙ৲峕ඹ峵嵉崓崳崢嵈ਙ峘ਂ৸嵣౮ଞ峙൙崠崡崰嵕崽崋嵤‫ق‬੐৒୔୰ ‫ك‬岝୫੊༇岝ຜჹႈ೩岝峒峇峘ਔଝ峼৥峳岵峕峃峵崓嵓崹崌嵛 3-ཽႈ೩峔峓峘৅ඪ峨峉峙ப৲ਏ౤峒峔峍峐岮峵岞岽島峳峘୰ଙ๞സ峕峙岝崓嵓崹 崓嵓崹崌嵛ਃચ峘ಳ௤峨峉峙ᕓਤ岶ਬ岷କ岽峃ႈ

&DOSDLQ3URMHFW崌嵛峘ে৶ਃચ৶ੰ岶૑೼峑岬峵岞ম崿嵕崠崏崗崰峑峙岝崓嵓崹崌嵛఩஫৕੝૗

೩ਠ଴峕ৌ峁岝੒ଆ嵣੘௜嵣൧૵峼૭ચ峒峃峵ૼ৵৙໲৕嵆崎崡峘ੰෲ峼রੱ峕岝崓嵓崹崌嵛峘ৗૠਃચ峒峇峘嵉崓崳崢嵈峼৥峳岵峕峃峵岞୒৫৅੦ೕ峘નয়峼৯੐峃
 &;&/ 峕峲峵಍༳嵣岶峽಍ཝ峘ඊႵൾ௾嵉崓崳ୌ಍ཝ峼ਹ৷峁峉ৗ峁岮岶峽ඊႵ௜১峘ർด峒൉ఇ‫ڱ‬ਈ੺岝઺਋৓峔岶峽ඊႵ௜১岶৫৅岿島岝੗岹峘岶峽೩঻峘୵岶೰峹島峐岮峵岞峁岵峁岝峇島岶஍岵峔岮பਙᇯᯂ峮૶ਙஜഷ୰峘೩঻峬ൂே峒峁峐੗岮岞峇岽峑মଢ଼஢峑峙岝೑‫ر‬岶ৄ峎岻峉岶峽ඊႵੜਘ౤৕峒ಿஜഷ୰৲

崢嵈峒峇峘ে৶৓ਔଝ峼ੰ৥峁岝岶峽ඊႵ௜১ಉ
峘৫৅峕૽য়峐峵 岶峽嵣ஜഷ୰ୌ಍ཝ峘েோ峕૑೼峔఩஫৕峼৊

ୌ಍ཝ 3-়੟峼ৰ৷৲峃峵峉峫峘ଢ଼஢峼௓ਤ峃峵岞峨峉岝崺崰 L36 ಍ཝ峘သു௺峒崺崰৒峁岝ৗ峁岮岶峽ী৕ఏ৓ఇ峘৫৅峕峎峔岼峵

6WHP&HOO3URMHFW஑ඊႵ௺峼੅峎৿੟嵊崯嵓峼৷岮峐岝য৑峘岶峽ඊႵਃଡ峘ੰ৥峕峬රਅ 崺崰 L36 ಍ཝ峘૥ୡଵ৔ୗഷ峒崺崰஑ඊႵ௺峼੅ਉ ේ಻

峃峵岞岽島峳峙岝ৗ峁岮岶峽੘௜১峼৫৅峃峵峉峫峘੎ਏ峔崡崮崫崿峑岬峵岞峎嵆崎崡௺ଁ峘੿ল峼ৢ峂峐岝ৗ峁岮岶峽ඊႵ௜১৫৅峘ਉ৶峒௬੼௺峼નয়峃峵崧嵛崹崗ସ৻ප౮ଞ峕峲峵ႈ೩৅ඪਃଡ峘ੰ৥峒਑౪‫ڲ‬ᐨஜସ৻ප 3-
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ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡᅜෆእࡢ◊✲≧ἣᰁⰍయࡢ」〇 ⤌᥮࠼ ಟ᚟➼ࡢ◊✲ࡣࠊ✀ࠎࡢ⏕≀✀࡛㐍ࢇ࡛࠸ࡿࠋ」〇㛤ጞࡢ㓝⣲Ꮫⓗ◊✲ࡣฟⱆ㓝ẕࡢ⣔࡛ᅜእ࡛ᛴ㏿࡟㐍⾜ࡋ࡚࠸ࡿࠋᡃࠎࡣ」〇ࣉࣟࢢ࣒ࣛࡢไᚚᅉᏊRif1ࢆୡ⏺࡟ඛ㥑ࡅ࡚ྠᐃࡋࡓࠋRif1ࡣG4⤖ྜࢆ௓ࡋ࡚᰾⭷㏆ഐ࡟ᶵ⬟ⓗ࡞ࢡ࣐ࣟࢳࣥ㧗ḟᵓ㐀ࢆᙧᡂࡍࡿࠋཪࠊ⣽⳦࠿ࡽࣄࢺ
ࡲ࡛ಖᏑࡉࢀࡓᬑ㐢ⓗ࡞」〇㛤ጞᶵᵓ࡟G4ࡀ㛵୚ࡍࡿྍ⬟ᛶࢆᣦ᦬ࡋࡓࠋࡋ
࠿ࡋࠊG4ࡢࢤࣀ࣒ᶵ⬟ไᚚ࡟࠾ࡅࡿᙺ๭ࡢ඲యീࠊ⣽⬊ෆ࡛ࡢᏑᅾᵝᘧࠊࡑࡢᙧᡂࡀ࠸࠿࡟ไᚚࡉࢀࡿ࠿࡜࠸࠺᰿ᮏⓗ࡞ၥ㢟ࡀᮍゎỴ࡛࠶ࡿࠋ(3)

Kanoh et al. Life Science Alliance (2023) 6,320200613 Yang and Masai, Mol. Cell.
Biol. 43, 1-21 Nemeth et al. (2023) Chemical
iomedical Imaging㸹㸦2023㸧
1.157-167 Yoshizawa-Sugata et al. (2021) J. Biol. Chem. 297(6):101367 Irie et al.
J. Med. Chem. 64(19):14153-14164 Masai et al. (2020) BBRC, 531, 75 Yang et al.
(2019) E-life, 8. pii: e50796. Ito et al. (2019) Scientific Reports, 9(1), 18622 Masai
et al. (2019), Scientific Reports, 9(1), 8618 Kobayashi et al. (2019) Mol. Cell. Biol.
pii: e00364-18. Masai et al., J. Biol. Chem. 293, 17033 Moriyama et al. (2018) J.
Biol. Chem. 293, 3607 Irie et al. Eur. J. Med. Chem. 130, 406 Masai et al. (2017)
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et al. (2016) Cell Cycle 15, 1213 Tanaka et al. (2016) J. Biol. Chem. 291, 6316
e0132595 Kanoh et al. (2015) Nature Struct. Mol. Biol. 22, 889 Hisao Masai et al.
13th isDDRHD (Dec. 9-11th, 2022) Shenzhen,China,(Invited) Hisao Masai et al.
2022 INTERNATIONAL IBS CONFERENCE FOR GENOMIC INTEGRITY(October 18-20, 2022) Grand Josun Hotel, Haeundae, Busan, South Korea, (Invited)ṇ஭ ஂ㞝 ➨95ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࣒࢘2022ᖺ11᭶11᪥ࠊྡྂᒇᅜ
㝿఍㆟ሙࠊྡྂᒇࠊᣍᚅㅮ₇ ṇ஭ ஂ㞝ࡽ ➨45ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵࣉ2022ᖺ11᭶30 12᭶2᪥ ᖥᙇ࣓ࢵࢭࠊ༓ⴥ Hiroyuki Sasanuma➨81ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ ࢩ࣏ࣥࢪ࣒࢘ࠊ2022ᖺ9᭶31᪥-10᭶1᪥ࠊࣃࢩࣇ
࢕ࢥᶓ὾ࠊᶓ὾ࠊᣍᚅㅮ₇

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ᡂᯝࡢᴫせ

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Rif1-G4」ྜయࠊRif1-G4-⬡㉁」ྜయࡢศᏊᙧែ࠾ࡼࡧືែࢆCryo㟁㢧ࠊ ⥺⤖ᬗᵓ㐀ゎᯒ࠾ࡼࡧAFM࡟ࡼࡾヲ⣽࡟ゎᯒࠋ
࣭ Rif1Cᮎኚ␗యࡢࢡ࣐ࣟࢳࣥ⤖ྜࠊᰁⰍయ┦஫స⏝(HiC)ࡢゎᯒࠋ࣭ ᰾ෆᅉᏊࡢࣃ࣑ࣝࢺ࢖ࣝ໬ࡢ⏕≀Ꮫⓗᶵ⬟ࡢゎ᫂ࠋ࣭ G4/RNA-DNA hybrid౫ᏑⓗDNA」〇㛤ጞࡢ㓝ẕ⣽⬊ࠊື≀⣽⬊࡛ࡢ᳨ド࣭ ⾑Ύ㣚㣹ࠊ㧗 ࠊᾐ㏱ᅽࠊ㓟໬࡞࡝✀ࠎࡢ⏕యࢫࢺࣞࢫ࡟ࡼࡿ」〇㞀ᐖㄏᑟ࠶ࡿ࠸ࡣChk1άᛶ໬ࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ ClaspinࡢศᏊෆ┦஫స⏝࡟ࡼࡿάᛶไᚚ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ ⚄⤒ࠊ⾑⌫⣽⬊࡟࠾ࡅࡿCdc7ཬࡧASK㠀౫ᏑⓗቑṪࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ ᪂つG4ࣉ࣮ࣟࣈࡢ㛤Ⓨ࡜ࡑࢀࢆ⏝࠸ࡓࠊ⣽⬊ෆࡢG4ᵓ㐀ࡢࢤࣀ࣒ࣉࣟࣇ࢓
࢖ࣝࠊࢲ࢖ࢼ࣑ࢡࢫࡢゎᯒࠋ࣭ Cdc7㜼ᐖ࡜ࡢే⏝࡟ࡼࡾ⣽⬊Ṛࢆㄏᑟࡍࡿ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ
࣭ BRCA1, BRCA2ࡢ⮚ჾ≉␗ⓗAID࣐࢘ࢫࢆᶞ❧ࡋࠊࡑࡢ⾲⌧ᆺࢆゎᯒࡍࡿࠋ(2)

࣭ Rif1Cᮎ㡿ᇦࡣࠊ୧ぶ፹ᛶcoiled-coilᵓ᝿ࢆ௓ࡋ࡚ࣜࣥ⬡㉁࡜┦஫స⏝ࡍࡿࠋ࣭ Rif1ࡣ」ᩘ⟠ᡤ࡟ࣃ࣑ࣝࢺ࢖ࣝ໬ࢆ࠺ࡅࠊRif1ࡢdetergent୙⁐⏬ศ࡬ࡢ㞟✚࡟ᚲせ࡛࠶ࡿࠋࡲࡓࠊ✀ࠎࡢ᰾ෆ」〇ᅉᏊࡶࣃ࣑ࣝࢺ࢖ࣝ໬ࢆཷࡅࡿࡇ࡜ࢆぢฟࡋࠊࡑࢀࡀࠊ」ྜయᙧᡂࠊ᰾ෆᒁᅾ࡟ᚲせ࡛࠶ࡿࡇ࡜ࢆⓎぢࡋࡓࠋ࣭ ㌿෗ࣉ࣮ࣟࣔࢱ࣮࡜G4ᙧᡂ㓄ิ࠿ࡽ኱⭠⳦ࢤࣀ࣒඲యࢆ」〇ࡋ࠺ࡿ」〇㛤ጞࣘࢽࢵࢺࢆྜᡂࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋ࣭ ✀ࠎࡢ⏕యࢫࢺࣞࢫࡣࠊG1ᮇ࠾ࡼࡧSᮇࡢ୧⪅࡟࠾࠸࡚ࠊࡑࢀࡒࢀࠊClaspin㠀౫ᏑⓗࠊClaspin౫Ꮡⓗ࡟」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺࢆάᛶ໬ࡍࡿࠋ
࣭ Integrated stress response (IRS)⤒㊰࡛άᛶ໬ࡉࢀࡿISR, PERK, HIRࡣࠊheat࡞࡝࡟ࡼࡿChk1άᛶ໬࡟ᚲせ࡜ࡉࢀࡿࠋ
࣭ Cdc7,ASKࡣⓎ⏕ึᮇ࡟࠾ࡅࡿ⚄⤒ᖿ⣽⬊ࡢ⬻Ⓨ⏕࡟ᚲ㡲࡛ࡣ࡞࠸ࡀࠊㄌ⏕ᚋࡢᑠ⬻ࠊ኱⬻ࡢᙧᡂ࡟ᚲ㡲࡛࠶ࡿࠋࡲࡓࠊቑṪࡢࡳ࡛࡞ࡃࠊᒙᵓ㐀ᙧᡂ࡟ᚲせ࡞⣽⬊⛣ື࡟Cdc7ࡀᙺ๭ࢆᯝࡓࡍྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ࣭ ⾑⌫⣽⬊࡟࠾࠸࡚ࡣࠊ」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺάᛶ໬ࡣClaspinࣀࢵࢡ࢔࢘ࢺᰴ࡛ࡶほᐹࡉࢀࡿࠋࡋࡓࡀࡗ࡚ࠊT/B⣽⬊࡛ࡣClaspin௨እࡢ௰௓ศᏊࡀ」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺࢆάᛶ໬ࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ
࣭ Cdc7㜼ᐖ࡜ ee1㜼ᐖ๣ࠊ࠶ࡿ࠸ࡣ ATR㜼ᐖ๣ే⏝࡛ࡀࢇ⣽⬊Ṛࢆㄏᑟ࡛ࡁࡿ
ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ࣭ ⢭〇ࡋࡓ඲㛗࣐࢘ࢫRif1ࢱࣥࣃࢡ㉁ࢆAFM࡛ゎᯒࡋࡓ⤖ᯝࠊRif1ࡣIDP౫Ꮡⓗ࡟ࢲ࢖ࢼ࣑ࢵࢡ࡟ᵓ㐀ࢆኚ໬ࡉࡏࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ங⒴ࡢཎᅉ㑇ఏᏊ࡛࠶ࡿBRCA1, BRCA2ࠊࢤࣀ࣒୙ᏳᐃᛶࢆㄏᑟࡍࡿDSBᙧᡂ࡟㛵㐃ࡍࡿTop1,Top2,Top3࡞࡝ࡢAID⣽⬊ᰴࠊ࣐࢘ࢫࢆᶞ❧ࡋࡓࠋ◊       ✲       ᡂ       ᯝඹྠ◊✲⪅ᑠ㔝 ᐩ⏨㸦㑇ఏᏊᨵኚ㸧㐍⸨ ┿⏤⨾㸦⺮ⓑゎᯒᐊ㸧୸ᒣ ༓⛅㸦⬻⚄⤒ᅇ㊰ᙧᡂ㸧㛗⃝ ࿴ኵ㸦ᮾி㎰ᕤ኱㸧
Huilin Li㸦Van Andel ResearchInstitute㸧⚄⏣ ኱㍜㸦஑ᕞ኱Ꮫ㸧ᖹ㇂ ఀᬛᮁ㸦⌮◊㸧ᰘ⏣ ᖿᙪ㸦㔠ἑ኱Ꮫ㸧(2) ◊✲⪅ྡ
➲἟ ༤அ
㧗஭ ⿱Ꮚ
⏣୰ ༟
ຍ⣡ ㇏
஭ཱྀ ᬛᘯ
⏣ᓥ 㝧୍
ఀ⸨ ࡉࡺࡾ
Chi-Chun Yang(1) ◊✲ᮇ㛫
2020ᖺ4᭶㹼2025ᖺ3᭶
㸦5ᖺ㛫㸧

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  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ṇ஭ ஂ㞝㸧㸦◊✲௦⾲⪅ྡ㸧◊  ✲  ෆ  ᐜࢤࣀ࣒ࡢ⥅ᢎ࣭⥔ᣢ࡜ࡑࡢ㞀ᐖ࡟ࡼࡿࡀࢇ࡞࡝ࡢ⑌ᝈⓎ⏕ࡢศᏊᶵᵓ㸭ࢤࣀ࣒ືែࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊✲ㄢ㢟ྡᡃࠎࡣࠊᰁⰍయࡢ」〇ࢆ୰ᚰ࡟ࢤࣀ࣒ࡢᏳᐃ࡞⥔ᣢ࡜ఏ᧛࡟㛵୚ࡍࡿࢤࣀ࣒ไᚚ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࢆ┠ᣦࡋ࡚࠸ࡿࠋࡇࡢࡓࡵ࡟ࠊᰁⰍయ」〇ࢆไᚚࡍࡿࢤࣀ࣒㡿ᇦࢆྠᐃࡋࠊ㌿෗࡟ࡼࡾᙧᡂࡉࢀࡿࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀࡟౫Ꮡࡍࡿ」〇㛤ጞࡢᬑ㐢ⓗᶵᵓࡢゎᯒࢆ㐍ࡵࡓࠋࡲࡓࠊᰁⰍయ㧗ḟᵓ㐀ࢆᙧᡂࡍࡿࢱࣥࣃࢡ㉁ࡢᶵ⬟ࠊᵓ㐀ࠊ⣽⬊⭷࡜ࡢ┦஫స⏝ࡢ࣓࢝ࢽࢬ࣒ࢆ᫂
ࡽ࠿࡟ࡋࡓࠋ」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺάᛶ໬࡟࠾ࡅࡿClaspinࡢไᚚᶵᵓࢆゎ᫂ࡋࠊࡀࢇ⣽⬊࡜ṇᖖ⣽⬊࡟࠾ࡅࡿ」〇ไᚚᶵᵓࡢ㐪࠸ࢆⓎぢࡋࠊࡑࢀ࡟ࡼࡿ᪂つไࡀࢇᡓ␎ࢆᥦၐࡋࡓࠋ

(1)୺࡞◊✲ᡂᯝ 

－7－

ᡂᯝࡢᴫせ
ձ࣐࢘ࢫ 12 ␒ᰁⰍయୖࡢຍ㱋ᛶ㞴⫈Ⓨ⑕᢬ᢠᛶ㑇ఏᏊࡢ᥈⣴MSM/Ms (MSM) ࣐࢘ࢫࡣຍ㱋ᛶ㞴⫈ࡢⓎ⑕࡟᢬ᢠᛶࢆ♧ࡍࠋᡃࠎࡣ MSM ࡢຍ㱋ᛶ㞴⫈᢬ᢠᛶ࡟㛵୚ࡍࡿ㑇ఏᏊᗙࠊahl10 ࡀ➨
12 ␒ᰁⰍయࡢࢭࣥࢺ࣓ࣟ࢔ഃ࠾ࡼࡑ 9.1 Mb ࡢ㡿ᇦ࡟఩⨨ࡍࡿࡇ࡜ࢆሗ࿌ࡋࡓ (Biomedicines 2022) ࠋᡃࠎࡣࡇࡢ㡿ᇦ࡟Ꮡᅾࡍࡿ
㑇ఏᏊ⩌࠿ࡽຍ㱋ᛶ㞴⫈Ⓨ⑕᢬ᢠᛶ㑇ఏᏊࡢೃ⿵ࢆ⤠ࡾ㎸ࡴࡓ
ࡵࠊBacterial Artificial Chromosome (BAC) ࡢຍ㱋 ᛶ 㞴⫈ ࣔࢹ ࣝ
C57BL/6J (B6) ࣐࢘ࢫ࡬ࡢࢺࣛࣥࢫࢪ࢙ࢿࢩࢫࢆ⾜࠸ࠊahl10 㑇ఏᏊᗙෆࡢ 5 㑇ఏᏊࢆྵࡴ BAC ࢆᑟධࡋࡓࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐
࢘ࢫࡀࠊ≉࡟㧗㡢ᇦࡢຍ㱋ᛶ㞴⫈Ⓨ⑕ࢆᢚไࡍࡿࡇ࡜ࢆᐇドࡋࡓࠋࡇࡢ⤖ᯝࡣࠊBAC ෆ࡟ྵࡲࢀࡿ 5 㑇ఏᏊࡀຍ㱋ᛶ㞴⫈᢬ᢠᛶ࡟ᶵ⬟ࡍࡿࡇ࡜ࢆ♧၀ࡍࡿ᭷ຊ࡞᰿ᣐ࡜࡞ࡗࡓࠋ
(1)

ᴫせඛኳᛶ㞴⫈ࡣ᪂⏕ඣࡢ⣙1,000ே࡟1 ே࡜㧗㢖ᗘ࡛Ⓨ⑕ࡍࡿࠋࡲࡓࠊ⫈ຊࡣຍ㱋࡟క࠸⾶࠼ࠊ65ṓࢆ㉸࠼ࡿ㧗㱋⪅࡛ࡣ3
ே࡟1ேࡀຍ㱋ᛶ㞴⫈ࢆⓎ⑕ࡍࡿ࡜᥎ᐃࡉࢀ࡚࠸ࡿࠋࡉࡽ࡟ࠊ
༴㝤࡞㡢㡪࡛ࣞ࣋ࣝࡢࣃ࣮ࢯࢼ࣮ࣝ࢜ࢹ࢕࢜ࡢ౑⏝࡟ࡼࡾࠊ
10㹼30ṓୡ௦ࢆ୰ᚰ࡟ୡ⏺ࡢ10൨ே௨ୖࡀ⫈ぬ⤌⧊࣭⣽⬊ᦆയ࡟㉳ᅉࡋࡓ㦁㡢ᛶ㞴⫈ࢆⓎ⑕ࡍࡿྍ⬟ᛶ࡟ࡉࡽࡉࢀ࡚࠸
ࡿࠋᚑࡗ࡚ࠊ㞴⫈ࡢⓎ⑕࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠊデ᩿ἲࠊண㜵ἲ
࠾ࡼࡧ἞⒪ἲࡢ☜❧ࡣ௒ᚋ㧗㱋⪅ேཱྀࡀቑ኱ࡍࡿᮾி㒔࡟࡜ࡗ࡚㔜せ࡞ㄢ㢟࡛࠶ࡿࠋᡃࠎࡢࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ1㸧㡰㑇ఏᏛᢏ⾡࡟ᇶ࡙ࡃ࣐࢘ࢫ
ࣔࢹࣝ࠿ࡽ᪂ࡓ࡞㞴⫈ཎᅉ㑇ఏᏊࡢྠᐃࠊ2㸧㞴⫈ࡢ୺せ࡞ཎᅉ࡜࡞ࡿෆ⪥᭷ẟ⣽⬊ࡢᙧᡂ࣭⥔ᣢᶵᵓࡢゎ᫂ࠊ3㸧ࣄࢺ㞴⫈
ࡢⓎ⑕ᶵᗎࡢゎ᫂ࡢࡓࡵࡢື≀ࣔࢹࣝࡢᶞ❧࡟ᇶ࡙ࡁࠊ㞴⫈ࡢ᪂ࡓ࡞ண㜵࣭἞⒪ἲࡢ☜❧ࢆ┠ⓗ࡟◊✲ࢆᐇ᪋ࡍࡿࠋ

ղ࢝ࢻ࣊ࣜࣥ 23 㑇ఏᏊ࢔ࣞࣝ㛫ࡢ㦁㡢ᛶ㞴⫈࠿ࡽࡢᅇ᚟ࡢᕪ␗
࢝ࢻ࣊ࣜࣥ23 (CDH23) 㑇ఏᏊࡣࠊ㦁㡢ᛶ㞴⫈ࡢⓎ⑕࡟ࡶ㛵୚ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣB6࣐࢘ࢫࡢ㑇ఏⓗ⫼ᬒ࡟࠾࠸(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࡚ࠊ㔝⏕ᆺ࢔ࣞࣝ࡜ຍ㱋ᛶ㞴⫈ࡢⓎ⑕ཎᅉ࡛࠶ࡿCdh23ࡢࣁ࢖࣏࣭ Biomedicines, 10, 2221, 2022.
࣭ ་Ꮫࡢ࠶ࡺࡳ㸪282, 648-656, 2022.
ࣔࣝࣇ࢔ࣞࣝ㸦ahl㸧㛫ࡢ㦁㡢ឤཷᛶࢆㄪᰝࡋࡓࠋࡑࡢ⤖ᯝࠊ㔝࣭ ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ࡜࢖ࣥࢲࢫࢺ࣮ࣜ㸪80, 301-305, 2022.
⏕ᆺ࢔ࣞࣝࢆࡶࡘB6࣐࢘ࢫ࡛ࡣᭀ㟢ᚋ࡟඲㡢ᇦ୍࡛㐣ᛶ࡟㔜ᗘ㞴
࣭ 36th International Mammalian Genome Conference. March 28, ⫈ࢆⓎ⑕ࡍࡿࡀࠊ2㐌㛫ᚋࠊ⫈ຊࣞ࣋ࣝࡣᭀ㟢๓࡜ྠ⛬ᗘࡲࡓࡣ
2023, Tsukuba, Japan㍍ᗘ㞴⫈ࣞ࣋ࣝ࡟ᅇ᚟ࡋ࡚࠸ࡓࠋ୍᪉ࠊahl࢔ࣞࣝ࣍ࣔࡢ࣐࢘ࢫ
࡛ࡣࠊప୰㡢ᇦࡢ⫈ຊࡣ㍍ᗘ㞴⫈ࣞ࣋ࣝ࡬࡜ᅇ᚟ࡋࡓࡶࡢࡢࠊ㧗(3) ᅜෆእࡢ◊✲≧ἣ㡢ᇦ࡛ࡢ⫈ຊࡢᅇ᚟ࡀㄆࡵࡽࢀ࡞࠿ࡗࡓࠋࡲࡓࠊࡇࡢ୧࢔ࣞࣝ㛫ࣄࢺ࡟࠾࠸࡚ࡣࠊࡇࢀࡲ࡛120✀ࢆ㉸࠼ࡿ㞴⫈Ⓨ⑕ཎᅉ㑇 ࡢ㦁㡢ᛶ㞴⫈࠿ࡽࡢᅇ᚟ࡢᕪ␗ࡣࠊ᭷ẟ⣽⬊⫈ẟ㛫ࢆࡘ࡞ࡄ⫈ẟఏᏊࡀྠᐃࡉࢀ࡚࠸ࡿࡀࠊ࡯ࡰ඲࡚ࡀඛኳᛶ㞴⫈ࡢཎᅉ㑇ఏ ⣒ࡢ෌⏕⬟ࡢᕪ࡟㉳ᅉࡍࡿࡇ࡜ࡀ⾲⌧ᆺゎᯒ࡟ࡼࡗ࡚♧၀ࡉࢀᏊ࡛࠶ࡾࠊຍ㱋ᛶ㞴⫈ࡢཎᅉ㑇ఏᏊ࡟ࡘ࠸࡚ࡣࢤࣀ࣒㛵㐃ゎ ࡓࠋᯒ࡟࠾࠸࡚ᩘ✀ࡢከᆺ࡜ࡢ㛵㐃ࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊຠᯝࡀᐇドࡉࢀࡓ㑇ఏᏊࡣ࡯ࡰ࡞࠸ࠋࡲࡓࠊຍ㱋ᛶ㞴⫈᢬ᢠᛶ㑇ఏ (2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼Ꮚ࡟㛵ࡍࡿሗ࿌౛ࡣ3౛ࡢࡳ࡛࠶ࡿࠋࡉࡽ࡟ࠊ㦁㡢ᛶ㞴⫈࡜ ࣭ 㑇ఏᏊⓎ⌧ゎᯒ࠾ࡼࡧࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡢస〇࣭ゎᯒ࡟ࡼࡢ㛵㐃ࡀᐇドࡉࢀࡓ㑇ఏᏊࡣ࣐࢘ࢫ࡛ྠᐃࡉࢀࡓ3㑇ఏᏊࡢࡗ࡚ຍ㱋ᛶ㞴⫈㑇ఏᏊᗙahl10ࡢᐇែࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ࡳ࡛࠶ࡾࠊຍ㱋ᛶ㞴⫈ឤཷᛶ࣭᢬ᢠᛶ࠾ࡼࡧ㦁㡢ᛶ㞴⫈࡟㛵 ࣭ ヲ⣽࡞⾲⌧ᆺゎᯒ࠾ࡼࡧ㑇ఏᏊⓎ⌧ゎᯒ࡟ࡼࡗ࡚ࠊ⫈ẟ⣒ࡢࡍࡿ㑇ఏᏊࡢ᝟ሗࡣ࠸ࡲࡔஈࡋ࠸≧ἣ࡟࠶ࡿࠋ
෌⏕⬟ࡢ࣓࢝ࢽࢬ࣒࡬࢔ࣉ࣮ࣟࢳࡍࡿࠋ

(1)㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ㸦ᩍ⫱◊ಟ⏕㸧౳ 㞷ྵ㸦༠ຊ◊✲ဨ㸧
ⱝ஭ᜨ㔛
㕥ᮌἋ⌮
ᐑᆏຬ㍤

㸦ᐈဨ◊✲ဨ㸧
㮚ྜ⚽ᶞ
Ⲕᅭ ⱱ
ᯇᒸ㑥ᯞ
࿴⏣೺ኴ

㸦እ㒊ᨭ᥼◊✲ᢏ⾡ဨ㸧
㧘ᶫ࠶࠸
ẟ 㟇

㸦㠀ᖖ໅◊✲⿵ຓဨ㸧
Ornjira Prakhongcheep

(2)

◊✲⪅ྡ
㸦ᖖ໅◊✲ဨ㸧
ྜྷᕝḠு
Ᏻ⏣ಇᖹ
㛵 ඃኴ

◊✲ᮇ㛫
2020ᖺ4᭶䡚2025ᖺ3᭶
㸦5ᖺ㛫㸧

(1)

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
㞴⫈ࡢ㑇ఏⓗせᅉ࡜Ⓨ⑕ᶵᵓࡢゎ᫂㸭㞴⫈ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ྜྷᕝḠு㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ －－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ(3) ᅜෆእࡢ◊✲≧ἣ࢝ࣝࣃ࢖ࣥࢆྵࡴࢱࣥࣃࢡ㉁ศゎ⣔ࡣୡ⏺୰࡛άⓎ࡟◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿศ㔝࡛࠶ࡾࠊᵝࠎ࡞ࣄࢺ⑌ᝈࡢ἞⒪ᶆⓗ࡜ࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿࠋࡲࡓࠊ࢝ࣝࣃ࢖ࣥ㑇ఏᏊኚ␗࡟ࡼࡿࣄࢺ
⑌ᝈ࡟㛵ࡍࡿ◊✲࡜᝟ሗ஺᥮ࡢሙࡀ☜❧ࡉࢀ࡚ࡁ࡚࠸ࡿࠋᙜ
ࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࢝ࣝࣃ࢖ࣥ㑇ఏᏊᨵኚ࣐࢘ࢫࡢ⾲⌧ᆺ࡜⏕໬Ꮫⓗ࡞࢝ࣝࣃ࢖ࣥࡢ⏕⌮ᶵ⬟ゎᯒ⤖ᯝ࡜ࡢ⥲ྜࠊ≉࡟࢝ࣝࣃ࢖ࣥࢆ௓ࡋࡓ⣽⬊㛫࣭⤌⧊㛫ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࢆど㔝࡟ධࢀࡓ࢝ࣝࣃ࢖ࣥ◊✲ࢆᚰࡀࡅ࡚࠸ࡿࠋ

(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ BBA Mol Cell Res 1869 (2022) 119188.
࣭ Encyclopedia of Biological Chemistry III (2021) 280-291.
࣭ Bioscience Report 40 (2020) BSR20200552.
࣭ Biology Open 9(2020) bio048975.
࣭ BBA Proteins and Proteomics 1868 (2020) 140411.
࣭ ࠕ㞴⑓࡜ᅾᏯࢣ࢔ࠖ1 (2023) 14-18.
࣭ ➨95ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ (2020.9.9-11).
࣭ ➨94ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ (2021.11.3-5, web㛤ദ).
࣭ ➨93ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ (2020.9.14-16, web㛤ദ).

(1) ᴫせ࣭ ⣽⬊ෆࢱࣥࣃࢡ㉁ษ᩿㓝⣲ࠕ࢝ࣝࣃ࢖ࣥࠖάᛶࡢ␗ᖖ㸦୙඲ཬࡧஹ㐍㸧ࡣ⚄⤒ኚᛶ⑌ᝈࠊ➽ࢪࢫࢺࣟࣇ࢕࣮ࠊ㣗㐨
⅖ࠊ⓶⭵⑌ᝈࠊ║⑌ᝈࠊᚠ⎔ჾ⣔⑌ᝈ࡞࡝ࡢⓎ⑕ࡲࡓࡣᝏ໬せᅉ࡜࡞ࡿࠋ࣭ ࡇࢀࡽ⑌ᝈࡢ἞⒪࣭デ᩿ࡣࠊ♫఍ⓗ࡟኱ࡁ࡞ᚲせᛶ࡜⥭ᛴᛶࢆᣢࡕࠊከ㠃ⓗ࠿ࡘ⥅⥆ⓗ࡞࢔ࣉ࣮ࣟࢳ࡟ࡼࡗ࡚⑓ែࡢ
ศᏊᶵᵓࢆゎ᫂ࡍࡿࡇ࡜ࡀᚲせ࡛࠶ࡿࠋ࣭ ୙᫂࡞㒊ศࡢከ࠸ࠕ࢝ࣝࣃ࢖ࣥࠖࡀ⏕యᶵ⬟ࢆ⥔ᣢࡍࡿ࣓࢝ࢽࢬ࣒࡜ࡧ㛵㐃⑌ᝈࡢⓎ⑕ཎᅉ࣭ᶵᵓࢆゎ᫂ࡋࠊ἞⒪࣭
デ᩿࡬ࡢᒎ㛤ࢆ┠ᣦࡋ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ✲       ᡂ


ᯝ


◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ྛ࢝ࣝࣃ࢖ࣥࡢ㑇ఏᏊᨵኚ࣐࢘ࢫࡢ⾲⌧ᆺ࡟ࡘ࠸࡚ࠊศᏊ࣓
࢝ࢽࢬ࣒ࡢゎᯒࢆࡍࡍࡵࡿࠋ་Ꮫ◊࡟ᑟධࡉࢀ࡚࠸ࡿᵝࠎ࡞ࢩࢫࢸ࣒㸦ࢱࣥࣃࢡ㉁ཬࡧ㑇ఏᏊⓎ⌧ࡸࠊ⣽⬊ᙧែࡢゎᯒࢶ࣮ࣝ㸧ࢆ✚ᴟⓗ࡟ά⏝ࡋࠊᡤෆእࡢ࢚࢟ࢫࣃ࣮ࢺ࡜ࡢඹྠ◊✲ࢆᒎ㛤ࡍࡿࠋ◊✲⤖ᯝࢆࡶ࡜࡟ࠕ೺ᗣ࡞≧ែࢆಖࡘࡓࡵࡢ࢝ࣝࣃ
࢖ࣥࡢാࡁ᪉ࠖࢆ᫂☜࡟ࡍࡿࡇ࡜࡛ࠊ㒔Ẹࡢ೺ᗣቑ㐍ࡸ⛉Ꮫ࣭೺ᗣ࡟㛵ࡍࡿព㆑ࡢ㧗ᥭ࡟㈉⊩࡛ࡁࡿࡼ࠺࡞᝟ሗⓎಙࡢᶵ఍ࢆ
సࡗ࡚࠸ࡁࡓ࠸ࠋ

㦵᱁➽࡟Ⓨ⌧ࡍࡿ࢝ࣝࣃ࢖ࣥ 㸦CAPN 㸧࣭ CAPN3ᶵ⬟Ḟᦆ㸦ࣀࢵࢡ࢖ࣥ(KI)ࠊࣀࢵࢡ࢔࢘ࢺ(KO)㸧࣐࢘ࢫ࡛ࡣࠊ㦵᱁➽ࡢࡳ࡛࡞ࡃ⫢⮚࡟࠾ࡅࡿ௦ㅰࣂࣛࣥࢫࡢ␗ᖖ
ࡀㄆࡵࡽࢀࡿࠋ࣭ ᦆയࢆཷࡅࡓ㦵᱁➽࡟࠾࠸࡚ࠊCAPN3ࡢάᛶ໬࡜ࡑࡢᚋࡢᅇ
᚟ࡸ⤌⧊෌ᵓ⠏࡜ࢆ㛵㐃࡙ࡅࡿ」ᩘࡢศᏊࢆぢฟࡋࡓࠋ⓶⭵࡟Ⓨ⌧ࡍࡿ࢝ࣝࣃ࢖ࣥ 㸦CAPN 㸧࣭ CAPN12ࡢⓎ⌧ୖ᪼ࡣ⓶⭵⑌ᝈ㸦஝Ⓞ࡞࡝㸧ࡢ⑓ែᝏ໬࡜┦㛵ࡍࡿྍ⬟ᛶࡀ࠶ࡿࠋ
ୖ⓶⣽⬊࡟Ⓨ⌧ࡍࡿ࢝ࣝࣃ࢖ࣥ 㸦CAPN 㸧࣭ CAPN15࡟ࡣ⣽⬊㛫᥋╔ࢆㄪ⠇ࡍࡿᶵ⬟ࡀ࠶ࡾࠊࣘࣅ࢟ࢳࣥ㙐⤖ྜ࡟ࡼࡿࣘࢽ࣮ࢡ࡞ไᚚᶵᵓࢆᣢࡘࠋ
ࡑࡢ௚࣭ ࢝ࣝࣃ࢖ࣥ ࠊ࢝ࣝࣃ࢖ࣥ ࠊཬࡧࠊ࢝ࣝࣃ࢖ࣥ ࡣࠊ࠸ࡎࢀ
ࡶࣉࣟࢸ࢔࣮ࢮάᛶ࡟ࡼࡾᶵ⬟ࡋ࡚࠸ࡿࡇ࡜ࡀࠊ㑇ఏᏊᨵኚ࣐࢘ࢫཬࡧ⣽⬊ࡢゎᯒ࡟ࡼࡾ᫂☜࡟࡞ࡗࡓࠋ᪂つࡢᇶ㉁≉␗ᛶࡸάᛶ໬ᶵᵓࡢᏑᅾࡀ♧၀ࡉࢀࡿࠋ

㸦ᐈဨ◊✲ဨ㸧ᒣ㔝 ᫭ྐ኱ᾏ ᚸ㸦༠ຊ◊✲ဨ㸧
ሯ⏣ᓅ኱
♞Ἴ୍ኵ
ᑿᔱᏕ୍
ᒣᮏ ᆂ
ᑠᓥ ࿴⳹

㸦◊✲⿵ຓ㸧
ᅵ஭ዉ✑Ꮚ

◊✲⪅ྡ
ᑠ㔝ᘺᏊ
⛙ ຾ᚿ
ධỤ ᩔ
ஂᜏᬛ༤
኱ෆྐᏊ
㔝ཱྀ࠶ࡸ
(2)

(1) ᡂᯝࡢᴫせ(1) ◊✲ᮇ㛫ࣄࢺ⑌ᝈ࡟┤᥋㛵ࢃࡿ࢝ࣝࣃ࢖ࣥࡢᣲື࣭άᛶ␗ᖖࠊཬࡧࠊ
2020ᖺ4᭶㹼2025ᖺ3᭶࢝ࣝࣃ࢖ࣥࡢ᪂ࡓ࡞ᵓ㐀ᶵ⬟┦㛵࣭ไᚚᶵᵓ࡟ࡘ࠸࡚௨ୗࡢ▱
㸦5ᖺ㛫㸧
ぢࢆᚓࡓࠋ

◊


࢝ࣝࣃ࢖ࣥ࡟ࡼࡿ⏕యᶵ⬟⥔ᣢࡢศᏊᶵᵓ㸭࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠ㔝ᘺᏊ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－

－

(3)

ᅜෆእࡢ◊✲≧ἣḢ⡿࡛ಟ㣭᰾㓟࡜ࢳ࢙ࢵࢡ࣏࢖ࣥࢺ㜼ᐖ๣࡜ࢆ⤌ࡳྜࢃࡏࡓࡀࢇᝈ⪅ࡢ⮫ᗋ἞㦂ࡀ㐍⾜୰࡛࠶ࡿࠋࡋ࠿ࡋࠊࣄࢺࡢ⭘⒆ࢿ࢜ᢠཎࢆྠᐃࡍࡿ᭷ຠ࡞ᡭἲࡸࠊC CL14ࢆ฼⏝ࡋࡓච␿ቑᙉ๣ࡣࡲࡔ㛤Ⓨࡉࢀ࡚࠸࡞࠸ࠋT-ALL⸆࡟㛵ࡋ࡚ࡣࠊḢ⡿
࡛」ᩘࡢ⮫ᗋ἞㦂ࡀᐇ᪋ࡉࢀ࡚࠸ࡿࡀࠊㄆྍ࡟ࡣ⮳ࡗ࡚࠸࡞࠸ࠋ᭱ᚋ࡟ࠊDD 1ࢆྵࡵࡓRNA࣊ࣜࢣ࣮ࢫ⩌ࡣࠊࡀࢇ⣽⬊ࡢ㌿෗࡜⩻ヂ࡟῝ࡃ㛵ࢃࡗ࡚࠾ࡾࠊᏛ⾡ⓗ࡟࣍ࢵࢺ࡞◊✲ศ㔝࡜࡞ࡗ࡚࠸ࡿࠋ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Micromachines, 11: 305, 2020.
࣭ Exp. Cell Res., 390: 111915, 2020.
࣭ Bioorg. Med. Chem. Lett., 30: 127837, 2021.
࣭ Nucl. Acid Res., 2021. 49: e40, 2021.
࣭ J. Immunol., 207: 459-469, 2021.
࣭ Front. Cell Dev. Biol., 10: 870629, 2022.
࣭ Proc. Natl. Acad. Sci. U.S.A., 119: e2116027119, 2022.
࣭ Stem Cells, 40: 906-918, 2022.

(2)

(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼
MHCࣄࢺ໬࣐࢘ࢫ࡟ࡘ࠸࡚ࡣࠊ࣊ࢸ࣐ࣟ࢘ࢫࡢᮍཷ⢭༸ࢆ⏝࠸ࡓ㢧ᚤᤵ⢭࡟ࡼࡗ࡚࣐࣍ࣔ࢘ࢫ⣔⤫ࡢᶞ❧ࢆ┠ᣦࡍࠋࡇࢀ࡜
୪⾜ࡋ࡚ࠊ࣐࢘ࢫMHC᏶඲ḞᦆMHCࣄࢺ໬ES⣽⬊ࡢ⏕Ṫ⣔ิఏᦙࡶヨࡳࡿࠋࣄࢺiPS⣽⬊ࡢศ໬◊✲࡛ࡣࠊ㞴㢟࡛࠶ࡿ㐀⾑ᖿ⣽⬊ࡢศ໬ㄏᑟ࡟ຍ࠼ࠊᢠ⭘⒆άᛶࢆᣢࡘ࣐ࢡࣟࣇ࢓࣮ࢪࡢศ໬ㄏ ᑟ ࡟ࡶ ὀຊ ࡍࡿ ࠋ CpG DNA-C CL14ཷ ᐜయ ࡢ ◊✲ ࡟ 㛵ࡋ ࡚ࡣࠊྠᐃࡋࡓ2✀㢮ࡢ⭷ࢱࣥࣃࢡ㉁ࡢᙺ๭ࢆド᫂ࡋ࡚ࠊㄽᩥ໬ࢆ
┠ᣦࡍࠋᢠT-ALL⸆ࡢ㛤Ⓨ࡟ࡘ࠸࡚ࡣࠊࡇࢀࡲ࡛ࡢࢹ࣮ࢱࢆㄽᩥ
໬ࡋࡓᚋࠊRa 37/Ra 61ࡢT-ALL⣽⬊Ṛ⁛άᛶ࡜⬡⫫௦ㅰ㓝⣲࡜ࡢ㛵ಀゎ᫂࡟඲ຊࢆὀࡄࠋ᭱ᚋ࡟ࠊDD 1࡟㛵ࡋ࡚ࡣRTCB」ྜ
య࡟ࡼࡿtRNA splicingࡢไᚚᶵᵓࢆゎࡁ᫂࠿ࡋ࡚࠸ࡃࠋ

ᡂᯝࡢᴫせMHCࣄࢺ໬࣊ࢸ࣐ࣟ࢘ࢫࡢ⦾Ṫ࡟ᡂຌࡋࡓࠋࡲࡓࠊMHCࣄࢺ
໬࣐࣍ࣔ࢘ࢫࡀ⏕Ꮡ࡛ࡁ࡞࠸ሙྜ࡟ഛ࠼࡚ࠊMHCࣄࢺ໬࣊ࢸࣟ
ES⣽⬊ࡢ࣐࢘ࢫMHC㑇ఏᏊ⩌39ಶ඲࡚ࢆ◚ቯࡋࡓES⣽⬊ࢡ࣮ࣟࣥࢆసฟࡋࡓࠋ➨2࡟ࠊࣄࢺiPS⣽⬊ࡢ࢜ࣝ࢞ࣀ࢖ࢻศ໬ㄏᑟ⣔࡛
ࡣࠊFLT3ࡀⓎ⌧ࡋ࡚࠸࡞࠸ࡓࡵ㐀⾑ᖿ࣭๓㥑⣽⬊ࡢ⏘⏕ຠ⋡ࡀప࠸ࡇ࡜ࢆㄽᩥⓎ⾲ࡋࡓࠋࡑࡋ࡚ࠊFLT3ࡢ㐣๫Ⓨ⌧࡟ࡼࡗ࡚ࠊࣄࢺiPS⣽⬊࠿ࡽ࣐ࢡࣟࣇ࢓࣮ࢪࢆቑ⏘ࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋḟ࡟ࠊఇ╀ᮇࡢ⓶⭵࡛ࡣC CL14ࡢⓎ⌧ୖ᪼ࡀ㯤Ⰽࣈࢻ࢘⌫⳦ࡢ㐣ቑ Ṫ ࢆ 㜵 ࠸ ࡛ ࠸ ࡿ ࡇ ࡜ ࢆ ㄽ ᩥ Ⓨ ⾲ ࡋ ࡓ ࠋ ḟ ࡟ ࠊ CpGDNA/C CL14」ྜయ࡟ᑐࡍࡿཷᐜయ࡜ࡋ࡚ࠊ2✀㢮ࡢ⭷ࢱࣥࣃࢡ㉁A࡜BࢆྠᐃࡋࡓࠋAࡣCpG-DNAࡢ࢚ࣥࢻࢯ࣮࣒㐠ᦙ࡟㛵୚ࡋ
࡚࠸ࡓࠋ%㑇ఏᏊࢆḞᦆࡉࡏࡓ࣐࢘ࢫ࡛ࡣࠊCpG-DNAᢞ୚࡟ࡼࡿྠ⣔࣓ࣛࣀ࣮࣐⣽⬊ࡢቑṪᢚไຠᯝࡀቑᙉࡉࢀ࡚࠸ࡓࠋ➨3࡟ࠊᡃࠎࡀ๰ฟࡋࡓᢠT-ALL໬ྜ≀Ra 61࡟ࡣࠊ≉ᐃࡢ⬡⫫௦ㅰ㓝⣲ࢆ㧗Ⓨ⌧ࡍࡿᅛᙧ⒴⣽⬊ࢆin vitroཬࡧin vivo࡛Ṛ⁛ࡉࡏࡿຠᯝࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓࠋ᭱ᚋ࡟ࠊDD 1ࡣintronࢆྵࡴtRNAศᏊ✀ࡢsplicing࡟ᚲ㡲࡛࠶ࡿࡀࠊXBP1 mRNAࡢligation࡟ࡣ㛵୚ࡋ࡚࠸࡞࠸ࡇ࡜ࢆド᫂ࡋࡓ(ㄽᩥrevise୰)ࠋ
(1)

ᴫせ㏆ᖺࠊ࢜ࣉࢪ࣮࣎ࡢࡼ࠺࡞⏬ᮇⓗ࡞ࡀࢇච␿⒪ἲࡀ㛤Ⓨࡉࢀࠊከࡃࡢ㔜⑕ࡀࢇᝈ⪅ࡢ࿨ࡀᩆࢃࢀ࡚࠸ࡿࠋࡋ࠿ࡋࠊࡇࢀ
ࡽࡀຠ࠿࡞࠸ࡀࢇᝈ⪅ࡣከᩘᏑᅾࡋࠊࡀࢇච␿⒪ἲࡢ㐺⏝ᣑ኱࡜᪂ࡋ࠸ศᏊᶆⓗ⸆ࡢ㛤Ⓨࡀồࡵࡽࢀ࡚࠸ࡿࠋᮏ ◊✲࡛ࡣࠊࣄࢺࡢ⭘⒆ࢿ࢜ᢠཎࢆྠᐃࡍࡿࡓࡵࡢࢩࢫࢸ࣒ᵓ⠏ࠊCpG
DNA-C CL14࡟ࡼࡿࡀࢇච␿⣔άᛶ໬ࡢศᏊᶵᗎゎ᫂ࠊᛴᛶTࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓(T-ALL)࡟ᑐࡍࡿ≉ຠ⸆ࡢ㛤Ⓨࠊ⒴ᖿ⣽⬊ࡢRNA௦ㅰ࡟ാࡃRNA࣊ࣜࢣ࣮ࢫDD 1ࡢᶵ⬟ゎ᫂ࢆࠊ4ᮏࡢᰕ࡜ࡋࡓᇶ♏◊✲ࢆ᥎㐍ࡍࡿࠋ

(1)㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ(2) ◊✲⪅ྡ
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2020ᖺ4᭶㹼2025ᖺ3᭶
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ᴫせ
ࣘࣅ࢟ࢳ࣭ࣥࣉࣟࢸ࢔ࢯ࣮࣒⣔࡟ࡼࡿ㑅ᢥⓗࢱࣥࣃࢡ㉁ศゎࡢ␗ᖖࡀ⚄⤒ኚᛶ⑌ᝈࡸ⮬ᕫච␿⑌ᝈࠊࡀࢇࠊⓎ㐩㞀ᐖ࡞࡝ࡢᵝࠎ࡞⑌ᝈࢆᘬࡁ㉳ࡇࡍࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚ࡁࡓࠋࡋ࠿
ࡋࠊࣘࣅ࢟ࢳ࣭ࣥࣉࣟࢸ࢔ࢯ࣮࣒⣔ࡣ኱つᶍ࠿ࡘ」㞧࡞⏕య㜵ᚚࢩࢫࢸ࣒࡛࠶ࡾࠊᮍࡔ࡟㑅ᢥⓗ࡞ࢱࣥࣃࢡ㉁ศゎࢆಖ㞀ࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࡀ୙࡛᫂࠶ࡾࠊ㛵㐃⑌ᝈࡢⓎ⑕ᶵᵓࡶ୙
࡛᫂࠶ࡿࠋࡑࡇ࡛ࠊᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࣘࣅ࢟ࢳࣥಟ㣭ࡢᵓ㐀ከᵝᛶ㸦ࣘࣅ࢟ࢳࣥࢥ࣮ࢻ㸧ࠊࣉࣟࢸ࢔ࢯ࣮࣒ไᚚศ
Ꮚࠊࣉࣟࢸ࢔ࢯ࣮࣒ኚ␗࣐࢘ࢫ࡞࡝ࡢゎᯒࢆ㏻ࡌ࡚ࠊ㑅ᢥⓗࢱࣥࣃࢡ㉁ศゎࡢసືᶵᵓࢆศᏊ࡛ࣞ࣋ࣝ᫂ࡽ࠿࡟ࡍࡿ࡜࡜
ࡶ࡟ࠊࣉࣟࢸ࢔ࢯ࣮࣒㛵㐃⑌ᝈࡢⓎ⑕ᶵᵓࢆゎ᫂ࡍࡿࡇ࡜
࡛ࠊ㏆ᖺࠊ㐍ᒎࡀⴭࡋ࠸ࣘࣅ࢟ࢳࣥ๰⸆ࡢศᏊᇶ┙ࢆᥦ౪ࡍࡿࠋㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
Mol Cell 81, 1411-1424 (2021) Genes Cells 26, 298-312 (2021) J
Med Chem 64, 15868-15882 (2021) EMBO Rep 23, e51182 (2022)
Plant Cell 34, 1354-1374 (2022) Front Microbiol 13, 967019 (2022)
Nat Chem Biol 19, 311-322 (2023) ᐇ 㦂 ་ Ꮫ 39, 1620-1627(2021) ⏕໬Ꮫ 93, 536-540 (2021) MEDCHEM NE S 31, 136142 (2021) J Biochem 171, 261-268 (2022) ➨62ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ ᪥ᮏࣉࣟࢸ࣮࣒࢜Ꮫ఍2021ᖺ኱఍ ➨94ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ➨44ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ➨16ᅇ᪥ᮏࢣ࣑
࢝ࣝࣂ࢖࢜ࣟࢪ࣮Ꮫ఍ ᪥ᮏࣉࣟࢸ࣮࣒࢜Ꮫ఍2022ᖺ኱఍ࢤࣀ࣒๰⸆࣭๰Ⓨࣇ࢛࣮࣒ࣛ➨10ᅇࢩ࣏ࣥࢪ࣒࢘ ➨95ᅇ᪥ᮏ ⏕ ໬ Ꮫ ఍ ኱ ఍ ➨ 45 ᅇ ᪥ ᮏ ศ Ꮚ ⏕ ≀ Ꮫ ఍ ᖺ ఍ The 23rd
TMIMS International Symposiumᅜෆእࡢ◊✲≧ἣࣉࣟࢸ࢔ࢯ࣮࣒㜼ᐖ๣ࡸᶆⓗࢱࣥࣃࢡ㉁ศゎㄏᑟ๣࡞࡝ࣘࣅ
࢟ࢳࣥ๰⸆ࡀୡ⏺ⓗ࡟኱ࡁࡃ㐍ᒎࡋ࡚࠾ࡾࠊࣘࣅ࢟ࢳ࣭ࣥࣉ
ࣟࢸ࢔ࢯ࣮࣒⣔ࡢᇶ♏◊✲࡟ᑐࡍࡿࢽ࣮ࢬ࡜ᮇᚅࡀ㧗ࡲࡗ࡚࠸ࡿࠋᙜ◊✲ᐊࡣඛ➃ⓗ࡞ࣘࣅ࢟ࢳ࣭ࣥࣉࣟࢸ࣑࢜ࢡࢫゎᯒ
ἲࡸ඲㌟ᛶࣉࣟࢸ࢔ࢯ࣮࣒ኚ␗࣐࢘ࢫࡢ㛤Ⓨ࡟ᡂຌࡋ࡚࠾
ࡾࠊୡ⏺ⓗ࡟ࡳ࡚ࡶ㧗࠸◊✲ࣞ࣋ࣝ࡟࠶ࡿࠋ

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(1) ᡂᯝࡢᴫせձࣘࣅ࢟ࢳࣥಟ㣭ࡢᵓ㐀ከᵝᛶy ࢱ ࣥ ࣃ ࢡ ㉁ ศ ゎ ㄏ ᑟ ๣ ࡀ ࠊ K29/K48 ศ ᒱ ᆺ ࣘ ࣅ ࢟ ࢳ ࣥ 㙐 ࡸ
K11/K48/K63 ศᒱᆺࣘࣅ࢟ࢳࣥ㙐ࡢᙧᡂࢆㄏᑟࡋᶆⓗࢱࣥࣃࢡ㉁ࡢ
ࣉࣟࢸ࢔ࢯ࣮࣒ศゎࢆᙉຊ࡟ㄏᑟࡍࡿࡇ࡜ࢆぢฟࡋࡓ㸦Mol Cell
2021 Nat Chem Biol 2023㸧
y ⢾㙐ㄆ㆑ E3 ࣮ࣜ࢞ࢮ SCF-FBS2 ࡀ⢾ࢱࣥࣃࢡ㉁ࡢ⢾ࢆࣘࣅ࢟ࢳࣥ
໬ࡍࡿࡇ࡜ࢆⓎぢࡋࡓ㸦ㄽᩥ‽ഛ୰㸧ࠋy ࣉࣟࢫࢱࢢࣛࣥࢪࣥྜᡂ㓝⣲ H-PGDS ࢆศゎㄏᑟࡍࡿᶆⓗࢱࣥࣃࢡ㉁ศゎㄏᑟ๣ࢆᅜ❧⾨◊࡜ඹྠ㛤Ⓨࡋࠊప⃰ᗘ㸦100 pM㸧࡛ HPGDS ศゎࢆㄏᑟ࡛ࡁࡿࡇ࡜ࠊࣉࣟࢸ࣮࣒࢜ゎᯒ࡟ࡼࡾ࢜ࣇࢱ࣮ࢤ
ࢵࢺࡀⓙ↓࡛࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸦J Med Chem 2021㸧ࠋy ࣘࣅ࢟ࢳࣥ࡜㧗ぶ࿴ᛶ㸦Kd㸸 1 nM㸧࡛⤖ྜࡍࡿேᕤᢠయࣔࣀ࣎ࢹ
࢕ࢆྡ኱࡜ඹྠ㛤Ⓨࡋࠊࣃ࣮࢟ࣥࢯࣥ⑓ᝈ⪅⬻ษ∦ࡢࣞࣅ࣮ᑠయ
ࡢ᳨ฟ࡟᭷⏝࡛࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸦≉チฟ㢪 2022-10877㸧ࠋղࣉࣟࢸ࢔ࢯ࣮࣒ไᚚศᏊ
y 㧗ᾐ㏱ᅽࢫࢺࣞࢫ่⃭࡟ࡼࡾࣉࣟࢸ࢔ࢯ࣮࣒ࡀࣘࣅ࢟ࢳࣥ໬ᇶ㉁࡜ᾮ㸫ᾮ┦ศ㞳ࡋࠊࢱࣥࣃࢡ㉁ศゎࡢࡓࡵࡢ⣽⬊ෆᾮ⁲ࢆᙧᡂࡍࡿࡇ࡜ࢆ௨๓ሗ࿌ࡋࡓࡀ㸦Nature 2020㸧ࠊ⣽⬊⪁໬ࡸ ATP ࣞ࣋ࣝపୗ࡟࠾࠸࡚ྠᵝࡢᵓ㐀యࡀ⏕ࡌࡿࡇ࡜ࢆぢฟࡋࡓ㸦Nat Communㄅᨵゞ୰ࠊㄽᩥ‽ഛ୰㸧ࠋ≉࡟ ATP ࢫࢺࣞࢫᾮ⁲ࡣࠊゎᾘࡀ㐜ᘏࡍࡿ࡜ࣘࣅ࢟ࢳࣥ໬ᇶ㉁ࡀ୙⁐໬㸦┦㌿⛣㸧ࡍࡿࡇ࡜ࢆぢฟࡋࠊࣘࣅ࢟ࢳࣥ㝧ᛶᑒධయࡢᙧᡂ࡟㛵୚ࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋࠋy ࣉࣟࢸ࢔ࢯ࣮࣒࡜┦஫స⏝ࡍࡿࣘࣅ࢟ࢳ࣮ࣥࣜ࢞ࢮ E6-AP㸦ู⛠UBE3Aࠊ࢔ࣥࢪ࢙࣐ࣝࣥ⑕ೃ⩌ࡢ㈐௵㑇ఏᏊ㸧ࡢࣀࢵࢡ࢔࢘ࢺ⣽⬊࡟࠾࠸࡚ࠊ᪂⏕୙Ⰻࢱࣥࣃࢡ㉁ࡀ୙⁐ᛶ⏬ศ࡟⵳✚ࡍࡿࡇ࡜ࢆ
ⓎぢࡋࠊE6-AP ࡀࣜ࣎ࢯ࣮࣒ရ㉁⟶⌮ᶵᵓ࡜㛵㐃ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋճ ࣉࣟࢸ࢔ࢯ࣮࣒ኚ␗࣐࢘ࢫ
y Ⓨ㐩㞀ᐖᝈ⪅⏤᮶ࡢኚ␗ࢆࡶࡘ඲㌟ᛶࣉࣟࢸ࢔ࢯ࣮࣒ᶵ⬟ῶᙅ࣐࢘ࢫࡢ㛤Ⓨ࡟ᡂຌࡋࠊᡂ㛗㐜⁫ࠊ⭈ᶵ⬟పୗࠊ⫢ᶵ⬟పୗࡢ௚ࠊ
㢌㒊ᙧែ␗ᖖࡸືࡁฟࡋ㐜ᘏࠊୖ఩୰ᯡᛶࡢ③ぬ␗ᖖ࡞࡝ࡢ᪂ࡓ
࡞⾲⌧ᆺࢆぢฟࡋࡓ㸦≉㢪 2021-166891㸧ࠋ◊㸦༠ຊ◊✲ဨ㸧Ᏻ⏣ࡉࡸ㤶㸦ᐈဨ◊✲ဨ㸧ᮧ⏣ⱱ✑㸦ᮾ኱⸆㸧ᕝཎ⿱அ㸦㒔❧኱㸧ฟỈᗤ௓㸦ᅜ❧⾨◊㸧኱➉ྐ᫂㸦ᫍ⸆኱㸧ᯘ ๛௓㸦ྡ኱ᕤ㸧(2) ◊✲⪅ྡ㸦ᖖ໅◊✲ဨ㸧
బ఑ Ὀ
ྜྷ⏣㞷Ꮚ
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ࢱࣥࣃࢡ㉁௦ㅰ␗ᖖ࡟ࡼࡿ⑌ᝈⓎ⑕ᶵᵓࡢゎ᫂࡜ไᚚ㸭⺮ⓑ㉁௦ㅰࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸బ఑ Ὀ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

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◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊       ✲       ᡂ       ᯝ31␒┠ࡢࢢࣜࢩࣥ࠿ࡽ100␒┠ࡢࣟ࢖ࢩࣥࡲ࡛ࡀ⥺⥔࣭ ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼୰ᚰࢆᙧᡂࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ≉␗ⓗ࡞࣭ Yang Y, Shi Y, Schweighauser M, hang , Kotecha A, Murzin
PETࣜ࢞ࣥࢻ࡜ࡋ࡚㛤Ⓨ࡞࡝ࠊࣞࣅ࣮ᑠయ⑓ࡢࡼࡾⰋ
AG, Garringer HJ, Cullinane P , Saito Y, Foroud T, arner࠸デ᩿ἲࡢ㛤Ⓨ࡟ᙺ❧ࡘ࡜⪃࠼ࡽࢀࡿ(Nature 2022)ࠋ
TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B,
Hasegawa M, Lashley T, Scheres SH , Goedert M. Structures
RI Į-synuclein filaments from human brains with Lewy (2) ᵝࠎ࡞๗᳨⬻ࡢࢡࣛ࢖࢜㟁㢧ゎᯒ࠿ࡽࠊ᪂つ࢔࣑ࣟ࢖ࢻ
pathology. Nature 2022 Oct 610(7933):791-795.
TMEM106BࡀⓎぢࡉࢀࡓࠋTMEM106Bࡣࣛ࢖ࢯࢰ࣮࣒/࢚࣭ࣥ Schweighauser M, Arseni D, Bacioglu M, Huang M, L vestamࢻࢯ࣮࣒ࡢࢱࣥࣃࢡ㉁࡛࠶ࡿࠋᏙⓎᛶ࠾ࡼࡧ㑇ఏᛶࡢࢱ࢘
S, Shi Y, Yang Y, hang , Kotecha A, Garringer HJ, Vidal R,࢜ࣃࢳ࣮ࠊAș࢔࣑ࣟ࢖ࢻ࣮ࢩࢫࠊࢩࢾࢡࣞ࢖ࣀࣃࢳ࣮ࠊ
Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M,
TDP-43ࣉࣟࢸ࢖ࣀࣃࢳ࣮ࡢ22ே࡜ࠊ࢔࣑ࣟ࢖ࢻỿ╔ࢆㄆࡵ
Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs
࡞࠸ᑐ↷⪅3ேࡢ๓㢌ⴥ⓶㉁࡟࠾࠸࡚ࠊTMEM106B⥺⥔ࡀ
GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantiniྵࡲࢀᵓ㐀ࡀỴᐃࡉࢀࡓࠋᢠTMEM239ᢠయࢆ⏝࠸࡚ࠊ20MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres
101ṓࡢ೺ᖖ⪅16ྡࡢ๓㢌ⴥ⓶㉁ࡢ୙⁐ᛶᢳฟ≀ࢆゎᯒࡋࡓSH . Age-dependent formation of TMEM106B amyloid⤖ᯝࠊ27kDa௜㏆࡟୙⁐ᛶࣂࣥࢻࡀ᳨ฟࡉࢀࠊTMEM106B
filaments in human brains. Nature 2022 May, 605(7909):310ࡣຍ㱋౫Ꮡⓗ࡟⵳✚ࡍࡿ࡜⤖ㄽࡉࢀࡓࠋ
3148.
࣭ Tarutani A, Adachi T, Akatsu H, Hashizume Y, Hasegawa K,
Saito Y, Robinson AC, Mann DMA, Yoshida M, Murayama S, (3) ࢱ࢘࢜ࣃࢳ࣮ࠊࢩࢾࢡࣞ࢖ࣀࣃࢳ࣮ཬࡧ TDP-43ࣉࣟࢸ࢖ࣀ
Hasegawa M. Ultrastructural and biochemical classification ofࣃࢳ࣮ᝈ⪅⬻࡟⵳✚ࡍࡿ␗ᖖᆺࢱࣥࣃࢡ㉁ࡢ㉸ᚤ⣽ᵓ㐀
SDWKRJHQLF WDX Į-synuclein and TDP-43. Acta Neuropatholⓗࠊ⏕໬Ꮫⓗศ㢮࡟ࡘ࠸࡚᭱᪂ࡢ▱ぢࢆྵࡵ࡚ゎㄝࡋࡓ
2022 Jun 143(6):613-640. ௚࣭ ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ᅜෆእࡢ◊✲≧ἣ௒ᚋࡶࡲࡔゎ᫂ࡉࢀ࡚࠸࡞࠸ㄆ▱⑕ࡸ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែᙧ
ᮏ◊✲ࡢ⏕໬Ꮫࠊ⺮ⓑ໬Ꮫゎᯒ࡟ᇶ࡙࠸࡚⑓⌮デ᩿ࡀ☜ᐃ ᡂ࡜㐍⾜࡟㛵ࢃࡿ␗ᖖ⑓⌮࡟ࡘ࠸࡚ゎᯒࢆ㐍ࡵࠊ⣽⬊ࠊື≀ࣔࡉࢀࠊ⑌ᝈࡢデ᩿ࡸศ㢮࡟ᙺ❧ࡗ࡚࠸ࡿࠋᵓ⠏ࡉࢀࡓື≀ࣔ ࢹࣝࢆᵓ⠏ࡋࠊㄆ▱⑕ࡢ᰿ᮏⓗ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡓ࠸ࠋ
ࢹࣝࡣ἞⒪⸆ࡢホ౯࡞࡝࡟ࡶ౑ࢃࢀ࡚࠸ࡿࠋ

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◊✲⪅ྡ
㛗㇂ᕝᡂே
㔝୰ 㝯
㕥ᮌඖ἞㑻
㕥᥃㞞⨾
㧗ᯇⰾᶞ
ட㇂ᐩ⏤ᶞ
Ἑୖ ⥴
ᶡ㇂ឡ⌮
ஂỌ┾ᕷ

◊✲ᮇ㛫
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(1)

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ㄆ▱⑕ࡢศᏊᶵᵓ㸭ㄆ▱⑕ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㛗㇂ᕝᡂே㸧࣭ ᴫせ࣭ ᡂᯝࡢᴫせㄆ▱⑕ࡣࠊ⚄⤒ኚᛶࡢཎᅉࢱࣥࣃࢡ㉁ࡢ✀㢮㸦ࢱ࢘ࠊĮࢩ (1) ⚄⤒ኚᛶ⑌ᝈࡢ୰࡛2␒┠࡟ከ࠸ࣃ࣮࢟ࣥࢯࣥ⑓(PD)ࢾࢡࣞ࢖ࣥࠊTDP-43࡞࡝㸧࡟ࡼࡗ࡚ศ㢮ࡉࢀࠋ␗ᖖࢱࣥࣃࢡ
࡜ࣞࣅ࣮ᑠయᆺㄆ▱⑕(DLB)ᝈ⪅⬻࠿ࡽȘࢩࢾࢡࣞ࢖㉁⑓ኚࡢᗈࡀࡾ࡜⑓ែ㐍⾜ࡀ῝ࡃ㛵ಀࡋ࡚࠸ࡿࠋ⑓ኚᙧᡂ࣓
ࣥ⥺⥔ࢆㄪ〇ࡋࠊMRC࡜ඹྠ◊✲࡛ࡑࡢᵓ㐀ࢆゎ᫂ࡋ࢝ࢽࢬ࣒ཬࡧ⑓ែ㐍⾜ࢆᢚ࠼ࡿ἞⒪ἲࢆ㛤Ⓨࡍࡿࡓࡵࠊᝈ⪅ࡓࠋ1౛ࡢPDᝈ⪅ࠊ2౛ࡢㄆ▱⑕ࢆక࠺PDᝈ⪅ࠊ3౛ࡢ๗᳨⬻ࡢゎᯒࢆ⾜࠸ࠊࡑࡢ⤖ᯝࢆ⮫ᗋ⌧ሙ࡟㑏ඖࡍࡿ࡜ඹ
DLBᝈ⪅⬻࠿ࡽȘࢩࢾࢡࣞ࢖ࣥ⥺⥔ࢆゎᯒࡋࡓ⤖ᯝࠊ࡟ࠊᐇ㦂ࣔࢹࣝࡢస〇࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

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Eur J Neurosci. 56, 4558-4571 (2022)➨  ᅇ᪥ᮏ⚄⤒⛉ᏛᏛ఍ ᖺグ᠈◊✲఍ ᣍᚅㅮ₇➨ᅇ᪥ᮏࢩࣙ࢘ࢪࣙ࢘ࣂ࢚◊✲㞟఍ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(3)ᅜෆእࡢ◊✲≧ἣࢥࢿࢡࢺ࣮࣒ゎᯒ➼࠿ࡽ⚄⤒⣽⬊ࡢ⤖ྜᵝᘧࡀ୍⣽⬊࡛ࣞ࣋ࣝヲ⣽࡟㐍ࡳࠊྛ⾜ື㐣⛬࡛ࡢ⚄⤒άື࡟ᑐࡍࡿゎ๗Ꮫⓗᑐᛂ௜ࡅin vivo࢖࣓࣮ࢪࣥࢢ࡞࡝࡟ࡼࡾ኱ࡁࡃ㐍ᒎࡋ࡚࠸ࡿࠋ୍᪉࡛༢࡞ࡿ⚄⤒άື࡛ࡣㄝ᫂ฟ᮶࡞࠸஦㇟ࡶぢฟࡉࢀ࡚࠾ࡾࠊࡇࡢゎ᫂ࡀ⬻ࡢാࡁࢆ⌮ゎࡍࡿୖ࡛୙ྍḞ࡛࠶ࡿࡇ࡜ࡀㄆ㆑ࡉࢀ࡚ࡁ࡚࠸ࡿࠋ

࣭

࣭

(2)
࣭
࣭

(1)

ᴫせ
Ꮫ⩦࣭グ᠈ࡢ࣓࢝ࢽࢬ࣒ࢆ⣽⬊࣭ᅇ㊰ࣞ࣋ࣝ࠿ࡽ㑇ఏᏊ࣭ศᏊࣞ࣋ࣝ࡟࠿ࡅ࡚ゎᯒࡍࡿࠋ᫂ࡽ࠿࡟࡞ࡗࡓᏛ⩦グ᠈ࡢ࣓࢝ࢽࢬ࣒࡟↷ࡽࡋࠊຍ㱋ࡸ⑌ᝈ࡞࡝࡟ࡼࡾ㉳ࡇࡿㄆ▱㞀ᐖࡢཎᅉࢆ᫂ࡽ࠿࡟ࡋࠊண㜵࣭ᨵ
ၿ࣭἞⒪ࡢ᪉ἲㄽࡢ☜❧࡟㈉⊩ࡍࡿࠋ୺࡞◊✲ᡂᯝ✲       ᡂ
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௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ 㛗ᮇグ᠈Ꮫ⩦ᚋࡢグ᠈⑞㊧⣽⬊෌άᛶ໬࡜グ᠈㥆໬࡜ࡢ㛵ࢃࡾࢆ᫂ࡽ࠿࡟ࡍࡿࠋ࣭ ≧ἣ࡟ᛂࡌࡓᏛ⩦ࡢ㑅ᢥ࡜Რ༷ࡢ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡍࡿࡓ
ࡵࠊ㡰ග᮲௳௜ࡅ࡜㏫⾜᮲௳௜ࡅ࡛ㄏᑟࡉࢀࡿ⣽⬊ෆࢩࢢࢼࣝࡢ㐪࠸ࢆ᫂ࡽ࠿࡟ࡍࡿ࣭ ࢟ࣀࢥయ⚄⤒⣽⬊࡜DA⚄⤒⣽⬊ࡢ㛫࡛ᙧᡂࡉࢀࡿ┦஫ࢩࢼࣉࢫ࡟ࡼࡿ࢟ࣀࢥయ⚄⤒⣽⬊࠿ࡽࡢࢩࢼࣉࢫฟຊࡀ᮲௳௜ࡅᚋ
ࡢDAᨺฟ࡜Ꮫ⩦ᡂ❧࡟㛵୚ࡍࡿྍ⬟ᛶࢆㄪ࡭ࡿࠋ
࣭ ⇕㏨㑊࡟ࡼࡿ᎘ᝏ᝟ືࡢఏᰁ࡟ຍ࠼࡚ࠊ௚ࡢ᎘ᝏ᝟ືࡶどぬ᝟ሗࢆࡶ࡜࡟ఏᰁࡍࡿ࠿᳨ウࡍࡿࠋᡂᯝࡢᴫせ࣭ ຍ㱋య࡛ࡣ㛗ᮇグ᠈Ꮫ⩦ᚋグ᠈⑞㊧⣽⬊ࡢ෌άᛶ໬ࡀ㉳ࡇࡿࡇ࡜ࢆin vivoࡢⓎග࢖࣓࣮ࢪࣥࢢゎᯒ࠿ࡽぢฟࡋࡓࠋ࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚᎘ᝏᛶໝ࠸᮲௳௜ࡅ࡟࠾࠸࡚ࠊNMDAཷᐜయࡢMg2 ࣈࣟࢵࢡ࡟ࡼࡾࢩࣙࢵࢡ࡟ᛂࡌࡓグ᠈୰ᯡ࢟ࣀࢥయ
⚄⤒⣽⬊࡬ࡢCa2 ὶධࡀ㡰⾜᮲௳௜ࡅ࡛㉳ࡇࡾࠊ㏫⾜᮲௳௜ࡅ࡛ࡣᢚไࡉࢀࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭ ᮲௳௜ࡅᚋ࡟ᣢ⥆ࡍࡿDAᨺฟࡀᏛ⩦ᙉ໬࡟ᯝࡓࡍᙺ๭ࢆㄪ
࡭ࠊᏛ⩦ࡣDAࡀ↓ࡃ࡜ࡶ୍᪦ࡣᡂ❧ࡍࡿࡀࠊࡑࡢᚋDAࡢᨺฟࡀ↓࠸࡜ᡂ❧ࡋࡓᏛ⩦ࡀ⥔ᣢ࡛ࡁ࡞ࡃ࡞ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟
ࡋࡓࠋ࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ᝟ືఏᰁࢆᢸ࠺୍⤌ࡢࢭࣟࢺࢽࣥసືᛶ
⚄⤒⣽⬊ࡀ୰ᚰయࡢᡪ≧యࡢ➨㸴ᒙ࡜ᴃ෇యࡢR3ᒙ࡟ᢞᑕࡋ
࡚࠸ࡿࡇ࡜ぢฟࡋࡓࠋࡉࡽ࡟➨㸴ᒙ࡟Ⓨ⌧ࡍࡿࢭࣟࢺࢽࣥ2B
ཷᐜయࡀ᝟ືఏᰁࡢ⾲ฟ࡟ᚲせ࡞ࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ
(1)

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(2) ◊✲⪅ྡ
㰺⸨ ᐇ
ᐑୗ▱அ
ୖ㔝⪔ᖹ
ᯇ㔝ඖ⨾
㛗㔝ៅኴ㑻
㕥ᮌຊ᠇
▼ᕝாᏹ

◊✲ᮇ㛫
2020ᖺ4᭶䡚2025ᖺ3᭶
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(1)

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Ꮫ⩦グ᠈ᅇ㊰ࡢືసཎ⌮࡜◚⥢ᶵᗎࡢゎ᫂㸭Ꮫ⩦グ᠈ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㰺⸨ ᐇ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－1 －◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᴫせ᪥ᮏ࡟ࡣ10୓ேࡢ⬨㧊ᦆയᝈ⪅ࠊ130୓ேࡢ⬻᱾ሰᝈ⪅ࡀ࠾ࡾࠊࡇࢀࡽࡢᝈ⪅ࡢ㯞⑷ࡋࡓ㐠ືᶵ⬟ࡸయᛶឤぬᶵ⬟ࢆྲྀࡾᡠࡍࡓࡵࡢ㠉᪂ⓗ࡞἞⒪ᡓ␎ࡀᚅᮃࡉࢀ࡚࠸ࡿࠋ⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࡇࢀࡲ࡛୙἞ࡢ⑓࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸
ࡓ⬻⬨㧊ᦆയ࡟ᑐࡍࡿ㠉᪂ⓗ࡞἞⒪ἲ͆ேᕤ⚄⤒᥋⥆͇ࢆ⬻᱾ሰᝈ⪅࡜⬨㧊ᦆയᝈ⪅࡟ᐇ㊶ࡋࠊᦆയ࡟ࡼࡗ࡚ኻࡗࡓᶵ⬟࡛࠶ࡿ͆⮬ศࡢ㌟యࢆឤࡌࠊ⮬ศ࡛ື࠿ࡍ͇ࡇ࡜ࢆ෌⋓ᚓࡍࡿࡇ࡜ࢆ┠ᣦࡍࠋࡲࡓࠊ⬻࣭⬨㧊ᦆയᝈ⪅ࡢከࡃࡣᚰࡢ⑓ࢆ
ేⓎࡋࠊࡑࢀࡀᶵ⬟ᅇ᚟ࡢጉࡆ࡟࡞ࡗ࡚࠸ࡿࠋࡑࡇ࡛ࠊ⢭⚄ᶵ⬟࡜㐠ືᶵ⬟ࡢྥୖࢆಁࡍ௓ධἲࢆ㛤Ⓨࡍࡿࠋ(1)㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

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ashin

㧗ᶫ⌶ဢ㸦ᶓ὾ᕷ❧኱Ꮫ㸧㜿㒊ᘯᇶ㸦ᶓ὾ᕷ❧኱Ꮫ㸧୰ᓥ࿴ᕼ㸦ᶓ὾ᕷ❧኱Ꮫ㸧ᾆ୸ᾈ୍㸦ᶓ὾ᕷ❧኱Ꮫ㸧ᫍ㔝┿ே㸦࣍ࣥࢲ㸧኱⇃஧㑻㸦࣍ࣥࢲ㸧᳝ྡ࠶ࡍ㤶㸦࣍ࣥࢲ㸧ᫍ⏤㈡㔛㸦࣍ࣥࢲ㸧すᓥ඘ᓫ㸦࣍ࣥࢲ㸧Ⲉᮌᣅஓ㸦NTTࢹ࣮ࢱ㸧㛗ᒸ㝧㸦NTTࢹ࣮ࢱ㸧ᮧ㉺ࡲࡦࡿ㸦NTTࢹ࣮ࢱ㸧᱈ᮌ⨾Ⓩ㔛㸦NTTࢹ࣮ࢱ㸧ຍ⸨೺἞㸦ᅜ❧㛗ᑑ◊㸧㇂ᕝᗈᶞ㸦⸨⏣་⛉኱㸧ᱵ⏣㐩ஓ㸦ி㒔኱Ꮫ㸧ᑠụᖾ⏕㸦NTTே㛫᝟ሗ◊㸧㟷ᮌⰋ㍜㸦NTTே㛫᝟ሗ◊㸧ఀໃᓮ㝯ྖ(NTTே㛫᝟ሗ◊㸧℈㔝཭ᕼ㸦᪩✄⏣኱Ꮫ㸧㸦༠ຊ◊✲ဨ㸧Ἑྜ୍Ṋ㸦᪥ᮏ኱Ꮫ㸧Ᏹᕝ⩏୍㸦⚟ᓥ་⛉኱㸧
Steve Perlmutter (Univ ofgton)㸦ᐈဨ◊✲ဨ㸧(2) ◊✲⪅ྡすᮧᖾ⏨ࠊ୰ᒣ⩏ஂ⏣ῧṓᶞࠊᶓᒣ ಟⳢཎ ⩧ࠊ㕥ᮌ㏔ㄹව㔜⨾ᕼࠊ୰ᕝ ᫭
⮻⏣ ༖

(1)

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸すᮧᖾ⏨㸧㸦1㸧ᡂᯝࡢᴫせ࣭ ࣐࢝ࢡࢧ࡛ࣝ໬Ꮫ㑇ఏᏛⓗ࡟㐠ືไᚚᶵᵓࡢ⚄⤒άືࢆ㈿ά
ࡉࡏࠊ㐠ື⬟ຊࢆྥୖࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓࠋ࣭ ࡚ࢇ࠿ࢇᝈ⪅ࡀ⬻่⃭࡟ࡼࡗ࡚ច㉳ࡉࢀࡓయᛶឤぬ⤒㦂ࡢᙉᗘࢆࣜ࢔ࣝࢱ࢖࣒࡟ሗ࿌࡛ࡁࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭ ᣑᩓ⚄⤒ࢺࣛࢡࢺࢢࣛࣇ࢕ἲࢆ⏝࠸࡚ࠊࣄࢺࡢྠഃ⓶㉁⬨㧊
㊰ࡢⓎฟ⓶㉁㡿ᇦࡢྠᐃࠊ⓶㉁ෆࡢศᕸࡢᐃ㔞໬ࡋࡓࠋ࣭ ⓶㉁⚄⤒⣽⬊࡜⬨㧊㛫ࡢேᕤ⚄⤒᥋⥆ࢆ㐺⏝ࡍࡿࡇ࡜࡛⬨㧊ᦆയࢧࣝࡢ㯞⑷ᡭࡢຊㄪ⠇ᶵ⬟ࢆ෌ᘓࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋ࣭ ពḧࢆྖࡿ୰⬻⓶㉁⣔ࡀࠊ㐠ືᡂ⦼ࡢ᪥ෆኚືࡔࡅ࡛࡞ࡃࠊ
᪥ࢆ㉸࠼ࡓ㛗ᮇኚື࡜ࡶ㛵㐃ࡍࡿࡇ࡜ࢆ❧ドࡋࡓࠋ࣭ ┠ⓗ㐩ᡂࡢࡓࡵࡢ⾜ືࢆᐇ⌧ࡓࡵ࡟ࠊࣄࢺࡢ⫼ഃ㐠ື๓㔝ෆ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ࡀᙺ๭ศᢸࡋ࡚࠸ࡿࡇ࡜ࢆぢฟࡋࡓࠋㄽᩥᥖ㍕ㄅ࣭ ⬨㧊ᦆയᚋ࡟Ṍ⾜㛵㐃ࡢ⬨㧊ෆᅇ㊰ࡀ෌⤌⧊ࡍࡿࡇ࡜ࢆぢฟ࣭ J Physiol ࣭ Front Neural Circuits ࣭ NeuroImage, ࣭ NeuroscienceࡋࡓࠋResearch࣭Front Syst Neurosci࣭Front Human Neurosci࣭Front Bioeng࣭ ୙඲㯞⑷ᝈ⪅࡟ᑐࡍࡿேᕤ⚄⤒᥋⥆ࢆ⏝࠸ࡓṌ⾜ࣜࣁຠᯝࡀ
Biotechnol࣭Proceedings of the National Academy of Sciences࣭eLife,ᐇドࡉࢀࡓࠋ
࣭Front Neurosci࣭BRAIN and NERVE(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࠋⓎ⾲Ꮫ఍࣭ ࢧ࡛ࣝ໬Ꮫ㑇ఏᏛ࡟ࡼࡿ⤒㊰㑅ᢥⓗ⚄⤒άື᧯సࢆ⾜࠸ࠊ㐠࣭➨45ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭FENS FORUM 2022.
ືไᚚ࡟࠾ࡅࡿྛୗ⾜㊰ࡢᶵ⬟ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
࣭➨16ᅇMotor Control◊✲఍࣭51st annual meeting of the Society for࣭࡚ࢇ࠿ࢇᝈ⪅ࡢయᛶឤぬ㔝ࢆୖ⫥ࡢຊࡸ఩⨨࡟ᛂࡌ࡚㟁Ẽ่
Neuroscience ࣭ ➨ 99 ᅇ ᪥ ᮏ ⏕ ⌮ Ꮫ ఍ ኱ ఍ ࣭ ASENT2023 Annual⃭ࡋࠊࡑࡢ᝟ሗࢆ฼⏝ࡋ࡚㐠ືࢆไᚚ࡛ࡁࡿ࠿ࢆ᳨ドࡍࡿࠋ
Meeting of Neurotherapeutics Conference(3) ᅜෆእࡢ◊✲≧ἣ࣭ 㝶ព㐠ືไᚚࢆᨭ࠼ࡿ⬻⬨㧊ࡢᶵ⬟㐃㛵ࢆྍど໬ࡍࡿࠋ⬨㧊࡬ࡢேᕤ⚄⤒᥋⥆ࡣすᮧࡀࣃ࢖࢜ࢽ࢔࡛࠶ࡾࠊ⚄⤒ᶵ ࣭ ᦠᖏྍ⬟࡞ேᕤ⚄⤒᥋⥆࡛⮬⏤⾜ືୗࡢ⬨㧊ᦆയࢧࣝࡢ㯞⑷ᗎゎ᫂ࢆ┠ᣦࡋࡓ◊✲࡛ࡶࠊ⮫ᗋ◊✲࡟࠾࠸࡚ࡶୡ⏺ࢆඛᑟ⫥ࡢᢕᣢ࣭ᘬࡁୖࡆ㐠ືࢆ෌ᘓ࡛ࡁࡿࡇ࡜ࢆ♧ࡍࠋࡋ࡚࠸ࡿࠋࡲࡓࠊື≀ࣔࢹࣝࢆ⏝࠸ࡓពḧ࡟㛵ࢃࡿഃᆘ᰾ࡀ ࣭ ⭡ഃ୰⬻ࡢ㐠ືᡂ⦼ྥୖ࡬ࡢᅉᯝⓗᙺ๭ࢆ᳨ドࡍࡿࠋ⬨㧊ᦆയᚋ࡟ᶵ⬟ᅇ᚟࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ◊✲ࡶࠊす ࣭ ࣄࢺ࡟࠾࠸࡚ࠊ⑂ປ᫬࡟㝈⏺ࢆ㉺࠼࡚ୖ⫥ࡢຊࢆⓎ᥹ࡍࡿ㐣ᮧࡀぢฟࡋࡓࡶࡢ࡛࠶ࡾࠊࡑࢀࢆࣄࢺ࡬ᒎ㛤ࡋ࡚࠸ࡿࠋࡇࡢ
⛬ࡢ⚄⤒ᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ᡂᯝࡣ⢭⚄⛉㡿ᇦ࡜ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ㡿ᇦࢆ⧅ࡆࡿࡶࡢ࡜ ࣭ ៏ᛶᮇ⬨㧊ᦆയᝈ⪅࡟࠾ࡅࡿேᕤ⚄⤒᥋⥆ࣜࣁࡢ⚄⤒ᶵᗎࢆ࡞ࡿ࡜⪃࠼ࡽࢀࠊ௒ᚋ኱ࡁ࡞ὀ┠ࡀ㞟ࡲࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ
♧ࡋࠊ៏ᛶᮇ⬻༞୰ᝈ⪅ࢆᑐ㇟࡜ࡋࡓேᕤ⚄⤒᥋⥆ࣜࣁࢆ≉ᐃ⮫ᗋ◊✲࡜ࡋ࡚ᐇ᪋ࡍࡿࠋ

୺࡞◊✲ᡂᯝ

－1 －◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ࢘࢖ࣝࢫ㛵㐃ᛴᛶ⬻⑕࡟㛵ࡍࡿ◊✲ࡣ౫↛❧ࡕ㐜ࢀ࡚࠸ࡿࡀࠊᡃࠎࡶཧຍࡋ࡚࠸ࡿᅜෆእࡢከᶵ㛵ඹྠ◊✲ࡀ㐍⾜ࡋ࡚࠸ࡿࠋࡲࡓᙜࣉࣟࢪ࢙ࢡࢺࡣᑠඣࡢච␿ᛶ⚄⤒⑌ᝈ࡟㛵ࡍࡿ⮫ᗋ࣭ᇶ♏◊✲ࢆᐇ᪋ࡋ࡚࠸ࡿᩘᑡ࡞࠸◊✲ᐊ࡛࠶ࡿࠋ᪂ᆺ
ࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡣ཰᮰ࡋࡘࡘ࠶ࡿࡀࠊྜే⑕࡜ࡋ࡚ࡢ
ᛴᛶ⬻⑕࡟ࡘ࠸࡚ᘬࡁ⥆ࡁ᳨ウࡍࡿᚲせࡀ࠶ࡿࠋRheb㜼ᐖ๣ࡢ◊✲ࡣᙜ◊✲ᐊ⊂⮬ࡢࡶࡢ࡛࠶ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ㄽᩥᥖ㍕
࣭ J Neurosci, Front Neurosci (2ሗ), Brain Dev≉ู࣭ᩍ⫱ㅮ₇࣭ ᪥ᮏᑠඣ⚄⤒Ꮫ఍࣭᪥ᮏᑠඣ⛉Ꮫ఍࣭ Asian Society for Pediatric ResearchᏛ఍Ⓨ⾲᪥ᮏ⚄⤒ච␿Ꮫ఍

(1)

ᴫせձ ⮫ᗋ◊✲
1) ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡢ⚄⤒ྜే⑕࡟㛵ࡍࡿ◊✲,2) ⮬ᕫච␿ᛶ⚄⤒⑌ᝈ࡜ᢠ⚄⤒ᢠయ3) Infection-triggered encephalopathy syndrome(ITES)࡟㛵ࡍࡿᅜ㝿ࢥࣥࢭࣥࢧࢫࡢᙧᡂ
4) ᑠඣච␿ᛶ⚄⤒⑌ᝈ࡟ᑐࡍࡿデ⒪ࡢᶆ‽໬ղ ᇶ♏◊✲
5) Rhebࡢάᛶ໬ࢆ୰ᚰ࡜ࡋࡓࢩࢢࢼࣝఏ㐩␗ᖖ࡟╔┠ࡋࡓ⤖⠇ᛶ◳໬⑕ࡢ⑓ែゎ᫂6) Pilocarpine TLR ligands඲㌟ᢞ୚࡟ࡼࡿ᪂ࡓ࡞࣐࢘ࢫࡅ࠸
ࢀࢇ㔜✚ࣔࢹࣝࡢసᡂ
7) ࣄࢺMOGᢠయࡢ⑓ཎᛶࡢゎ᫂୺࡞◊✲ᡂᯝ 

࣭

࣭

(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⮫ᗋ◊✲࡛ࡣᘬࡁ⥆ࡁከᶵ㛵ඹྠ◊✲ࢆᇶ┙࡜ࡍࡿ⮫ᗋ◊✲࣭ࣂ࢖࣐࣮࣮࢜࢝◊✲ࢆ⥅⥆ࡍࡿࠋࡲࡓᑠඣච␿ᛶ⚄⤒⑌ᝈࡢデ᩿ᇶ‽ࡸデ⒪࢞࢖ࢻࣛ࢖ࣥసᡂ࡞࡝ࢆ㏻ࡌ࡚ᑠඣ
⚄⤒⑌ᝈࡢデ⒪Ỉ‽ࡢྥୖ࡟㈉⊩ࡍࡿࠋᇶ♏◊✲࡛ࡣࢩࢼࣉࢫྍረᛶ␗ᖖࡢศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒
ࢆ୰ᚰ࡟⤖⠇ᛶ◳໬⑕➼ࡢ⚄⤒Ⓨ㐩⑕㛵㐃⑌ᝈࡢ◊✲࡟ຊࢆධࢀࡿࠋࡲࡓᑠඣ⚄⤒⑌ᝈࡢື≀ࣔࢹࣝࢆ⏝࠸ࡓ◊✲ࢆ
Ⓨᒎࡉࡏࡿࠋᡂᯝࡢᴫせձ ⮫ᗋ◊✲
1) ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕࡟క࠸ᡃࡀᅜ࡛31౛ࡢᑠඣᛴᛶ
⬻⑕ࡀⓎ⏕ࡋࡓࡇ࡜ࢆሗ࿌ࡋࠊࡑࡢ⮫ᗋⓗ≉ᚩ࡜ணᚋࢆ᫂
ࡽ࠿࡟ࡋࡓ㸦Front Neurosci㸧ࠋ2) ⮬ᕫච␿ᛶ࡚ࢇ࠿ࢇ࡟࠾ࡅࡿᢠ⚄⤒ᢠయ㝧ᛶࢆண ࡍࡿAPEࢫࢥ࢔ࡢᑠඣ࡟࠾ࡅࡿ᭷⏝ᛶࢆ᳨ウࡋࡓࠋ3) ITES࡟㛵ࡍࡿᅜ㝿◊✲ࢢ࣮ࣝࣉࢆ⤌⧊ࡋ࡚࣓ࢱ࢔ࢼࣜࢩࢫ
ࢆ㛤ጞࡋࡓ࡯࠿ࠊᅜ㝿デ᩿ᇶ‽ࡢసᡂ࡟ྲྀࡾ᥃࠿ࡗࡓࠋ
4) ᑠඣᛴᛶ⬻⑕デ⒪࢞࢖ࢻࣛ࢖ࣥࢆᨵゞࡋࡓ࡯࠿ࠊ⮬ᕫච␿ᛶ⬻⅖࡟㛵ࡍࡿᡃࡀᅜึࡢ඲ᅜㄪᰝ࡟ຍࢃࡗࡓࠋղ ᇶ♏◊✲
5) Rheb㜼ᐖ๣࡛࠶ࡿlonafarnibࡀin vivo࡟࠾࠸࡚Rhebࡢάᛶ໬ࢆ㜼ᐖࡋࠊࡉࡽ࡟Tsc2ኚ␗࣐࢘ࢫ࡟࠾࠸࡚ほᐹࡉࢀࡿグ᠈␗ᖖࡸ⚄⤒⣽⬊ࡢᶞ≧✺㉳ࢫࣃ࢖ࣥࡢᙧែ␗ᖖࢆṇᖖ໬ࡉࡏࡿࡇ࡜ࢆぢฟࡋࡓ㸦J Neurosci㸧ࠋ6) ᪂ࡓ࡞࣐࢘ࢫࣔࢹ࡛ࣝࠊࡅ࠸ࢀࢇࡢ㔜⑕໬࡜⮴Ṛ⋡ࡢቑຍ࣭⾑ᾮ⬻㛵㛛㏱㐣ᛶஹ㐍ࠊ⬻ෆࡢ⅖⑕ᛶࢧ࢖ࢺ࢝࢖ࣥࡢቑ
ຍ࡜࠸࠺ேࡢᛴᛶ⬻⑕࡟㏆࠸⑓ែࡢ෌⌧࡟ᡂຌࡋࡓࠋ
7) MOGᢠయ㛵㐃⑌ᝈ࡛ぢࡽࢀࡿࣄࢺMOGᢠయࡀ⿵యࢆ௓ࡋ࡚
⣽⬊㞀ᐖ⬟ࢆ♧ࡍࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸦Front Neurosci㸧ࠋ(1)◊       ✲       ᡂ       ᯝ
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◊✲ᮇ㛫

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ᯘ 㞞ᬕ

ᮾி㒔❧⚄⤒⑓㝔ᫍ㔝 ឡᮾி㒔❧ᗓ୰⒪⫱ࢭࣥࢱ࣮
ᑠඣ⛉
⏣἟┤அ

⬻࣭⚄⤒⛉Ꮫ◊✲ศ㔝
బஂ㛫ၨ
ᓥ⏣ᛅஅ
⚄ᒣ㑥Ꮚ
ᇼ㔝ᮅᏊ
す⏣⿱ဢ
᳃ᒣ๢ග
୰஭⌮ᜨ
᳃ ㈗ᖾ
⸨⏣ᇶ㈨
㕥ᮌᬛ඾
ከ⏣ᘯᏊ

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2020ᖺ4᭶䡚2025ᖺ3᭶
㸦5ᖺ㛫㸧

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ࡇ࡝ࡶࡢ⬻ࡢࡓࡵࡢࢺࣛࣥࢫ࣮ࣞࢩࣙࢼࣝ◊✲㸭ࡇ࡝ࡶࡢ⬻ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸బஂ㛫ၨ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 15 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

after ischemic stroke. Neurosci Res. (2023)
Sakai S, Shichita T. Role of alarmins in poststroke
inflammation and neuronal repair. Semin Immunopathol.
(2022)➨51ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍
➨65ᅇ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍➨40ᅇ᪥ᮏࣄࢺ⣽⬊Ꮫ఍
➨63ᅇ᪥ᮏ⚄⤒Ꮫ఍ᅜෆእࡢ◊✲≧ἣ⬻࡟࠾ࡅࡿ⅖⑕⑓ែࡣࠊᵝࠎ࡞⚄⤒࣭⢭⚄⑌ᝈ࡟ᑐࡍࡿ᭷
ᮃ࡞἞⒪ᶆⓗ࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠾ࡾࠊୡ⏺ⓗ࡞㛵ᚰࡀ㧗ࡲࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺࡣ୺࡟⬻༞୰ࢆ㢟ᮦ࡜ࡋ࡚◊✲ࢆ㐍ࡵ࡚࠾ࡾࠊ⬻᱾ሰᚋࡢ⅖⑕࡟࠾ࡅࡿศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ࡢヲ⣽ࢆࠊୡ⏺࡟ඛ㥑ࡅ࡚ゎ᫂ࡋࡓ㸦Nat Med 2009, 2012,2017, Nature 2019㸧ࠋ➨㸲ᮇࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻༞୰ᚋࡢಟ᚟ᶵ㌿ࡢศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ࡢゎ᫂࡟ᣮࢇ࡛࠾ࡾࠊ⬻༞୰ᚋࡢᶵ⬟ᅇ᚟ࢆᣢ⥆ࡉࡏࡿ἞⒪⸆㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋ

࣭

࣭
࣭
࣭
࣭
࣭

Ꮫ఍ㅮ₇㸦ᣍᚅㅮ₇㸧
Stroke Immunology Conference㸦ᅜ㝿⬻༞୰ච␿఍㆟㸧࣭⥲ㄝ࣭ Koyama R, Shichita T. Glial roles in sterile inflammation࣭ ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ㄽᩥᥖ㍕
࣭ PLOS Biol. 19(5):e3000939 (2021)

ᴫせ⬻༞୰ࡣṚᅉࡢ➨఩ࠊᐷࡓࡁࡾࡢཎᅉࡢ➨఩ࢆ༨ࡵ࡚࠸
ࡿࠋᮏ㑥࡛ࡣ⬻༞୰ᑐ⟇ᇶᮏἲࡀᡂ❧ࡋࠊ⬻༞୰ᝈ⪅ࡢᶵ⬟ணᚋࢆᨵၿࡍࡿ἞⒪ᡭẁࡢ☜❧ࡀồࡵࡽࢀ࡚࠸ࡿࠋᮏ◊✲࡛ࡣࠊ⬻༞୰࡛ᦆയࡋࡓ⚄⤒ᅇ㊰ࢆࠊ௦ൾⓗ࡟෌ᵓ⠏ࡍࡿࡓࡵࡢ⬻⣽⬊ࢆㄏᑟ࣭⥔ᣢࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋ࡚ࠊ⏬ᮇⓗ࡞⚄⤒ᶵ⬟ᨵၿ⸆ࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡿࠋ

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2020ᖺ4᭶㹼2023ᖺ3᭶㸦3 ᖺ㛫㸧
(1)

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⬻᱾ሰᚋࡢಟ᚟ࢆᣢ⥆ࡉࡏࡿ἞⒪㛤Ⓨ⬻᱾ሰᚋࡢ࣑ࢡࣟࢢࣜ࢔ࡀಟ᚟ᶵ⬟ࢆ᭷ࡍࡿ஦ࢆぢฟࡋࠊࡇࢀࡽ
ࡢಟ᚟ᛶ࣑ࢡࣟࢢࣜ࢔ࡣಟ᚟ࡢᙺ๭ࢆ⤊࠼࡚ࡶ࡞࠾ࠊ⬻⤌⧊࡟ṧࡾ⥆ࡅࡿࡇ࡜ࢆⓎぢࡋࡓࠋಟ᚟ᶵ⬟ࢆ⤊ࢃࡽࡏࡿ㌿෗ᅉᏊࡢྠᐃ࠿
ࡽࠊ࣑ࢡࣟࢢࣜ࢔࡟ࡼࡿಟ᚟ᶵ⬟ࢆᣢ⥆ࡉࡏࡿࡇ࡜࡟ࡼࡾ⬻᱾ሰᚋࡢᶵ⬟ᅇ᚟ࢆಁ㐍ࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࡇ࡜ࢆド᫂ࡋࡓࠋճ(2) ◊✲⪅ྡᖖ໅◊✲ဨ୐⏣ ᓫղ ⬻᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࣓࢝ࢽࢬ࣒ࡢゎ᫂㓇஭ㄔ୍㑻⬻᱾ሰ࡟࠾ࡅࡿࣜࣥ⬡㉁࡜ࡑࡢ௦ㅰ≀࡟ὀ┠ࡋ࡚◊✲ࢆ㐍ࡵࠊ⬻ ὠᒣ ῟
᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࡟㛵ࢃࡿ᪂つࡢ⬻ಟ᚟ⓗ࡞⬡㉁ࢆྠᐃ
ࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋ⬻᱾ሰ࿘ᅖ࡛⏘⏕ࡉࢀࡿ࣍ࢫ࣍ࣜࣃ࣮ࢮA2ࡣ⬻ಟ᚟ⓗ⬡㉁ࢆ⏕ᡂࡋࠊ⚄⤒⣽⬊࡟ᑐࡋ࡚⚄⤒ಟ᚟ⓗ࡞స⏝ࢆࡶࡓࡽࡍࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ⬻᱾ሰ࡟ᑐࡍࡿ἞⒪๣࡜ࡋ࡚⬻ಟ᚟ⓗ࡞⬡㉁ࢆ⏝࠸ࡿࡇ࡜ࡀྍ⬟࡞࡯࠿ࠊ⏬ᮇⓗ࡞⬻ᶵ⬟ᅇ᚟㣗ࡢ㛤Ⓨ࡟ᛂ⏝ྍ⬟࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿ㸦≉チ⏦ㄳ῭ࡳࠊㄽᩥᢞ✏୰㸧ࠋ

ձ

ᡂᯝࡢᴫせ
⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞⅖⑕ច㉳ᅉᏊࡢྠᐃ⬻ ᱾ ሰ ࡟ ࠾ ࡅ ࡿ ᪂ つ ࡢ ෆ ᅉ ᛶ ⅖ ⑕ ច ㉳ ᅉ Ꮚ ࡜ ࡋ ࡚ DJ-1
㸦Park7㸧ࢱࣥࣃࢡ㉁ࢆྠᐃࡋࡓࠋ⣽⬊እ࡟ᨺฟࡉࢀࡓ DJ-1 ࡣ
⅖⑕ࢆច㉳ࡍࡿస⏝ࢆ᭷ࡍࡿࡇ࡜࠿ࡽ⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞἞⒪ᶆⓗ࡜࡞ࡾᚓࡿࡇ࡜ࡀド࡛᫂ࡁࡓ㸦PLOS Biol 2021㸧ࠋ

(1)

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⬻༞୰ᚋࡢ⚄⤒ಟ᚟࡟㛵ࢃࡿศᏊ㺃⣽⬊࣓࢝ࢽࢬ࣒ࡢゎ᫂㸭⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୐⏣ ᓫ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 16 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡࢩࢼࣉࢫᙧᡂࡸ⚄⤒⣽⬊⛣ື࡞࡝⚄⤒ᅇ㊰ᙧᡂึᮇࡢ␗ᖖࡀ
ᵝࠎ࡞⢭⚄⑌ᝈࡢཎᅉ࡟࡞ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟ࡉࢀࡘࡘ࠶ࡿࠋ
ࡇࢀࡽ⑌ᝈࡢ⑓ᅉࢆゎ᫂ࡋࠊ㐺ษ࡞἞⒪ἲࢆ㛤Ⓨࡍࡿ࡟ࡣࠊ
⬻⚄⤒ᅇ㊰ᙧᡂࡢᇶ♏ⓗ࡞ศᏊᶵᵓࢆゎ᫂ࡍࡿᚲせࡀ࠶ࡿࠋࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡣ᭱ึᮇ࡟ㄌ⏕ࠊᡂ⇍ࡍࡿࢽ࣮ࣗࣟ
࡛ࣥࠊ⬻⚄⤒ᅇ㊰ᙧᡂࡢึᮇẁ㝵࡟㔜せ࡞ᙺ๭ࢆࡍࡿࡇ࡜ࡀ
♧၀ࡉࢀ࡚࠸ࡿࠋࡲࡓࠊࣉࣟࢸ࢜ࢢࣜ࢝ࣥࡢ␗ᖖ࡜⮬㛢⑕Ⓨ⑕࡜ࡢ㛵㐃ࡶ᫂ࡽ࠿࡟࡞ࡾࡘࡘ࠶ࡿࠋ

(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭bioRixiv (2023)
࣭Mol Psychiatry (2023)
࣭Front Neurosci (2022)
࣭Int J Mol Sci.(2021)
࣭Front.Cell Dev.Biol (2021)
࣭Sci Adv (2021)
࣭Front Neural Circuits.(2021)
࣭Cortical Development Conference (2022) ࢖ࢱࣜ࢔㸦ᣍᚅㅮ₇㸧࣭᪂Ꮫ⾡㡿ᇦ◊✲ࠕⓎ⏕᫬ィ࡜ሙࡢ㐃ᦠࠖᅜ㝿ࢩ࣏ࣥࢪ࣒࢘
㸦2022)㸦ᣍᚅㅮ₇㸧࣭᪥ᮏ⚄⤒⛉Ꮫ኱఍(2021,2022)
࣭ NEURO2022ࢩ࣏ࣥࢪ࣒࢘(2022)㸦ᣍᚅㅮ₇㸧࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍(2021ࠊ2022)
࣭(3) ᅜෆእࡢ◊✲≧ἣ

(1)

ᴫせᮏࣉࣟࢪ࢙ࢡࢺ◊✲ࡣ ͆⬻ࡢᵓ⠏ཎ⌮ࡢ⌮ゎ͇࡜࠸࠺ほⅬ࠿ࡽ࠿ࡽ⢭⚄࣭⚄⤒⑌ᝈⓎ⑕ཎᅉࡢゎ᫂࡟࢔ࣉ࣮ࣟࢳࡍ
ࡿࠋ⬻ᙧᡂ࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢᶵ⬟ゎᯒ࡟ࡼࡿ⬻ᵓ⠏ࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࡸࠊᇶᮏⓗ࡞ࢩࢼࣉࢫᙧᡂ
ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡛ࠊⓎ㐩㞀ᐖࠊᚰࡢ⑓ࡢཎᅉ
ࡸ㧗ḟ⬻ᶵ⬟ࡢ␗ᖖ࡟ࡘ࠸࡚ࡢ⌮ゎࢆ῝ࡵࠊᑗ᮶ⓗ࡟ࡣࡑࡢ἞⒪࡬ࡢᛂ⏝ࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ✲       ᡂ
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௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭࡬ࣃࣛࣥ◲㓟ࡢ⢾㙐ಟ㣭ࡢࢩࢼࣉࢫᙧᡂࠊཬࡧ኱⬻⓶㉁ᙧᡂ࡟
࠾ࡅࡿᶵ⬟ࢆゎᯒࡍࡿࠋ

࣭SpN ࡢᩘࢆ DT ẘ⣲࡟ࡼࡾῶᑡࡉࡏࡿ᮲௳ࢆỴᐃᚋࠊ⬻ᵓ⠏࡬ࡢᙳ㡪ࢆㄪ࡭ࡿ

࣭㟋㛗㢮࡛ SP ᒙࡀཌ࠸ࡇ࡜࡟ᐤ୚ࡋ࡚࠸ࡿศᏊ࣓࢝ࢽࢬ࣒ࢆゎ
᫂ࡍࡿ

(2)

ճ ⚄⤒ᅇ㊰ᙧᡂ࡟࠾ࡅࡿࣉࣟࢸ࢜ࢢࣜ࢝ࣥࡢᶵ⬟ゎᯒࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᗂ⹸ࡢ⚄⤒➽᥋ྜ㒊㸦NMJ㸧࡟࠾ࡅࡿࢩࢼ
ࣉࢫᙧᡂ࡟ᚲ㡲ࡢ HSPG ࡛࠶ࡿࢽ࣮ࣗࣞ࢟ࢩࣥ㸦Nrx)ࡢ HS
ࡀ௜ຍࡉࢀ࡚࠸࡞࠸࣑࣮ࣗࢱࣥࢺࢆసᡂࡋ࡚ゎᯒࡋࡓ⤖ᯝࠊࢩࢼࣉࢫᙧᡂ࡟ HS 㙐ࡀ㔜せ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
ࡲࡓ࣐࢘ࢫ࡛ Hs3st4 ࢆ⣽⬊✀≉␗ⓗ࡟ KO ࡍࡿࡓࡵࡢ flox ࣐࢘ࢫࢆసᡂࡋࡓࠋղ ከ ᑠ ⬻ᅇ ࡢ᪂ つࡢ ཎᅉ 㑇ఏᏊ Pa
ࡢ ࣐࢘ ࢫ⬻ ᵓ⠏ ࡟ ࠾ࡅࡿᶵ⬟ゎᯒ ከᑠ⬻ᅇࡢᝈ⪅࠿ࡽぢࡘ࠿ࡗ࡚ࡁࡓࠊPak2 ࡢ㑇ఏᏊኚ␗ࢆᣢࡘⓎ⌧ࣉࣛࢫ࣑ࢻࢆ࣐࢘ࢫ⬻ࡸࠊᇵ㣴⚄⤒⣽⬊࡬ᑟධࡍࡿ࡜ࠊ⣽⬊⛣ືࡢ␗ᖖࡸ࢔ࢡࢳࣥືែࡢ␗ᖖࡀぢࡽࢀࠊᮏ㑇ఏᏊࡢ⬻ᙧᡂ࡬ࡢ㛵୚ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ

ᡂᯝࡢᴫせձ ኱⬻⓶㉁ᙧᡂ࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥ SpN ࡢᶵ⬟⫾⏕ᮇࡢศᏊ࣐࣮࣮࢝ࡢྠᐃࢆ⾜࠸ࠊRNAScope ἲࢆ⏝࠸࡚Ⓨ⌧ࢆ☜ㄆࡋࠊࢧࣈࢱ࢖ࣉࡀྠᐃ࡛ࡁࡓࠋࡲࡓࠊ࣐࣮ࣔࢭࢵ
ࢺࠊࣄࢺ⫾ඣࡢ Visium ゎᯒࡶ⾜࠸ࠊ✀㛫࡛ࢧࣈࣉ࣮ࣞࢺᒙ࡛
ࡢⓎ⌧㑇ఏᏊࡢẚ㍑ゎᯒࢆ⾜࡞ࡗࡓࠋࡑࡢ⤖ᯝࠊ㟋㛗㢮≉␗ⓗ࡟Ⓨ⌧ࡀ㧗࠸㑇ఏᏊࢆྠᐃࡋࡓࠋࡲࡓࠊDTR/DT ࡢ⣔࡛ࢪࣇࢸࣜ࢔ẘ⣲࡟ࡼࡾ࣐࢘ࢫ SpN ࢆ ablation ࡍࡿ⣔ࡢ᮲௳᳨ウࢆ⾜ࡗࡓࠋSpN ࡢ኱⬻ࡢ⾑⟶ᙧᡂ࡬ࡢ㛵୚ࡶ☜ㄆ࡛ࡁࡓࠋ

(1)

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࣭◊ಟ⏕
㜿▱Ἴ ࡦ࡜ࡳ(ᮾ኱࣭㝔㸧࿴⏣ ி௓㸦᪂₲኱࣭㝔㸧᳃ᒸ Ṍክ㸦᪂₲኱࣭㝔㸧㔝ᮧ 㐶 ໭㔛኱ᮡ⏣ ♸㍜ ᮾி⌮⛉኱㸧∦ᒣ ᾴ㤶㸦᪩✄⏣኱㸧㔝ཱྀ ཭⌮ె㸦࠾Ⲕ኱࣭◊✲ᢏ⾡ဨᖹ஭ ஂ⨾Ꮚ
ᑠ⏣ᔱ ឡᏊ㧗ᶫ ῄᏊⰼᔱ ࠿ࡾ࡞㸦᪩✄⏣኱Ꮫ㸧࣭ᐈဨ◊✲ဨ
๓⏣ಙ᫂㸦๓࣮ࣜࢲ࣮㸧⏤Ⰻ ᩗ㸦࠾ⲔࡢỈዪᏊ኱㸧㔝ᮧ ┿㸦ி㒔ᗓ❧་኱㸧

(1)

◊✲ᮇ㛫
2020ᖺ4᭶䡚2025ᖺ3᭶㸦5ᖺ㛫㸧(2) ◊✲⪅ྡ
࣭◊✲ဨ
୸ᒣ ༓⛅
⚄ᮧ ᆂு
㝰ඖ ᣅ㤿
Ᏺᒇ ᩗᏊ
ᯇᮧ Ὀᏹ
㧗ἑ ඞᏊ
␊୰ ⏤⨾Ꮚ◊ ✲ᮇ  㛫࣭  ◊✲  ⪅ྡ  ➼
⬻࣭⚄⤒ᅇ㊰ࡢᵓ⠏ཎ⌮࡜ࡑࡢᙧᡂ␗ᖖࡢ࣓࢝ࢽࢬ࣒㸭⬻⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୸ᒣ༓⛅㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－ 17 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᅜෆእࡢ◊✲≧ἣࣄࢺࠊື≀ࠊ⣽⬊ࠊin vitro࡛ࣞ࣋ࣝࡢከ㠃ⓗどⅬ࠿ࡽࠊ⢾໬ࢫࢺࣞࢫኚᐜ࡜⾲⌧ᆺ࡜ࡢ㛵㐃ࠊ⢾໬ࡀ௓ᅾࡍࡿ㑇ఏᏊⓎ⌧ไᚚ࡞࡝ࠊ⢭⚄⑌ᝈࡢᛮ᫓ᮇⓎ⑕ᶵᗎ࡟㏕ࡿ◊✲ᡓ␎ࡣᅜෆእ࡟࠾࠸࡚ⓙ↓࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣᐈほⓗデ᩿࡟᭷⏝࡞ࣂ࢖࣐࣮࣮࢜࢝ࡢ᥈
⣴ࠊ⢾໬ไᚚࢆ㍈࡜ࡋࡓศᏊᶵᗎࡢゎ᫂ࢆ⥅⥆ࡋ࡚࠸ࡿࠋ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
Tabata et al. Schizophr 2022 Kirihara et al. Schizophr Res. 2022 Koike etal. Biochem Biophys Res Commun. 2022 Ishida et al. Psychiatry Res
Case Reports 1 2022 Inoue et al. Front. Physiol. 2022 Yamazaki et al. Surg
Today. 2022 Okamura et al. Healthcare 2022 Kushima et al. Psychiatry
Clin Neurosci. 2022 Yoshikawa et al. PLoS One. 2022 Ishiguro et al. Front
Psychiatry. 2022 Kushima et al. Biol Psychiatry 2022 Ruan et al. Nat
Genet. 2022 Toriumi et al. Front Genet. 2022 Suzuki et al. Schizophr 2022
Mizutani et al. Front Neurorobot. 2022 Suzuki et al. J Physiol. 2022
Sanada et al. J Epidemiol. 2022 Shinba et al. Sensors 2022 Arseni et al.
Nature. 2022 Endo et al. Schizophr Res. 2022 Toriumi et al. BioClinica
2022 Toriumi et al. Redox Biol. 2022 ௚ࠊ⥲ㄝ, ⣒ᕝࡽ, ᪥ᮏ་ᖌ఍
㞧ㄅ 2022 ⣒ᕝࡽ, ⢭⚄⚄⤒Ꮫ㞧ㄅ 2022 ⃝ࡽ, ᐇ㦂་Ꮫ 2022 ᇼෆࡽ, ⏕యࡢ໬Ꮫ 2022 ᇼෆࡽ, ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍ㄅ 2022ᅜෆᏛ఍ 27 ௳㸦᪥ᮏ⏕໬Ꮫ఍኱఍ࠊ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ࠊ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍ࠊ᪥ᮏ⢭⚄⚄⤒Ꮫ఍ࠊ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ࠊ᪥ᮏ
ᚤ㔞ඖ⣲Ꮫ఍㸧, ᬑཬάື࣭ㅮ₇఍➼ 36 ௳.

ᴫせձ㑇ఏᏊኚ␗ࢆ᭷ࡍࡿ⑕౛ࡸዌຌ⑕౛➼ࡢ௦ㅰ⏘≀࣭ࢤࣀ࣒࣭⮫ᗋ
᝟ሗࢆ㋃ࡲ࠼ࠊ⑌ᝈࡢணᚋண ࡸ἞⒪཯ᛂᛶ➼࡟ᐤ୚ࡍࡿࣂ࢖࣐࢜
࣮࣮࢝ࢆ᫂ࡽ࠿࡟ࡍࡿࠋղ๗᳨⬻࡛ࡢ▱ぢࢆᇶ┙࡟ࠊ⢾໬⬤ᙅᛶ࡟㛵ࢃࡿ⬻ෆ⑓ែᅇ㊰ࢆゎ᫂ࡍࡿࠋճ⢾໬⬤ᙅᛶࡢ㑇ఏ⣲ᅉࠊᚰ⌮♫఍ⓗࢫࢺࣞࢫ➼ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊ⮫ᗋ࡟ἢࡗࡓࣔࢹࣝື≀ࡢసฟ࡜⾜ື⸆⌮Ꮫⓗゎᯒࢆ᥎㐍ࡋࠊࡑࡢศᏊᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
մ⣽⬊ࣔࢹࣝࠊLQ YLWURࣔࢹࣝࢆά⏝ࡋࠊ᪂ࡓ࡞ᢠ⢾໬≀㉁ࡢࢫࢡ
࣮ࣜࢽࣥࢢ࡜ࡑࡢస⏝ᶵᗎࢆ⣽⬊࠿ࡽLQ YLWUR࡛ࣞ࣋ࣝゎ᫂ࡍࡿࠋյ㒔❧ᯇἑ⑓㝔ࠊࢤࣀ࣒་Ꮫ◊✲ࢭࣥࢱ࣮ࠊ♫఍೺ᗣ་Ꮫࢭࣥࢱ࣮
➼࡜㐃ᦠࢆᅗࡾࠊ⢾໬ไᚚ࡜ࣛ࢖ࣇࢫࢸ࣮ࢪࢆ㍈࡟ࠊ㠉᪂ⓗ࡞ண㜵࣭἞⒪ᡓ␎ࡢ๰ฟࠊ௓ධⅬࡢྠᐃࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ✲       ᡂ
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( ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ḟᖺᗘ௨㝆ࡶࠊ㒔❧ᯇἑ⑓㝔ࢆྵࡴ་⒪ᶵ㛵ࠊࢤࣀ࣒་Ꮫ◊✲ࢭࣥࢱ࣮ࠊ♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮ࠊ௚ࣉࣟࢪ࢙ࢡࢺ࡜㐃ᦠࡋࠊձྛ✀ࡢࣂ࢖࣐࣮࣮࢜࢝ࢆ㍈࡟ࠊ⢾໬ࢺࣛࢪ࢙ࢡࢺ࣮ࣜ࡜ࣛ࢖ࣇࢫࢸ࣮ࢪ࡟࠾ࡅࡿ
೺ᗣ࢔࢘ࢺ࣒࢝࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋղ⤫ྜኻㄪ⑕ࢆྵࡴ⑕౛ࠊཬ
ࡧᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺࣂ࢖࢜ࢧࣥࣉࣝࢹ࣮ࢱࢆά⏝ࡋࡓ┦஫᳨ド࠿ࡽࠊ⢾໬ࢺࣛࢪ࢙ࢡࢺ࣮ࣜࡢ㐓⬺ࢆᘬࡁ㉳ࡇࡍಟ㣭せᅉ㸦㑇ఏᅉ⎔ቃᅉ㸧ࢆྠᐃࡋࠊࡑࡢ௓ධ⟇ࢆ᫂ࡽ࠿࡟ࡍࡿࠋճ๗᳨⬻ࢆά⏝ࡋࡓ࣌ࣥࢺ
ࢩࢪࣥ⵳✚ࡢ⬻⑓⌮ゎᯒࢆ⥅⥆ࡍࡿࠋմ࣌ࣥࢺࢩࢪࣥ⵳✚ࣔࢹࣝື≀㸦࣐࢘ࢫ࣭࣐࢝ࢡࢨࣝ㸧࡛ࡢ⾜ືゎᯒ࡜ࡑࡢศᏊᶵᗎゎ᫂ࢆ᥎㐍ࡍࡿࠋյ࣌ࣥࢺࢩࢪࣥ⵳✚⣽⬊ࣔࢹࣝࢆά⏝ࡋࡓಟ㣭ࢱࣥࣃࢡ㉁ࡢྠᐃࡸண㜵࣭἞⒪⸆ࢫࢡ࣮ࣜࢽࣥࢢࢆ⥅⥆ࡋࠊࡑࡢస⏝ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿࠋն♫఍ᐇ⿦࡟⤖ࡧ௜ࡃ⢾໬ࡢไᚚ࣭᧯సἲࢆ᫂ࡽ࠿࡟ࡋࠊ⤫ྜኻㄪ⑕ࡢⓎ⑕࡜⑓ែቑᝏࡢண㜵ࡸ἞⒪ἲ㛤Ⓨࠊ೺ᗣᑑ࿨ࡢᘏఙ࡟ྥࡅࡓᨭ᥼⟇ࢆ๰ฟࡍࡿࠋ㸦 㸧ᡂᯝࡢᴫせ⤊ᮎ⢾໬⏘≀ࡢࡦ࡜ࡘ࡛࠶ࡿ࣌ࣥࢺࢩࢪࣥ⵳✚ࡀㄆࡵࡽࢀࡓ⤫ྜኻㄪ⑕࡟ࡘ࠸࡚ࠊ࣌ࣥࢺࢩࢪࣥࡀ⵳✚ࡍࡿ⚄⤒⣽⬊ࣔࢹࣝࠊ࣐࢘ࢫࣔࢹࣝࠊ࣐
࢝ࢡࢨࣝࣔࢹࣝࢆᵓ⠏ࡋࠊศᏊ⑓ែ࡟㛵ࡍࡿゎᯒࢆ᥎㐍ࡋࡓࠋࡲࡓࠊ⤫ྜኻㄪ⑕ᝈ⪅ࡢ๗᳨⬻ࡢゎᯒ࠿ࡽࠊ࣌ࣥࢺࢩࢪࣥ⵳✚ࡀ㢧ⴭ࡟ㄆࡵࡽࢀ
ࡿ⬻㒊఩ࢆ≉ᐃࡋࠊ⬻ෆ⬤ᙅ㒊఩࡜⚄⤒ᅇ㊰ࡢ୍➃ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ࣌
ࣥࢺࢩࢪࣥࡀ⵳✚ࡋࡓ⬻㡿ᇦࡣࠊど⫈ぬ᝟ሗࡢฎ⌮࡟ຍ࠼ࠊ」ᩘࡢឤぬ᝟ሗࢆ⤫ྜࡋࠊ⾜ືࡸᛮ⪃࡟⤖ࡧࡘࡅࡿᑠ⬻㸫኱⬻ᇶᗏ᰾㸫኱⬻㐃㛵࡬ࡢ㛵୚ࡀ♧၀ࡉࢀࡓࠋ
ᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ஦ᴗࢆ᥎㐍ࡍࡿ♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮࡜㐃ᦠࡋࠊᛮ᫓ᮇඣ❺࡟࠾࠸࡚⤫ྜኻㄪ⑕Ⓨ⑕ࣜࢫࢡ࡜⪃࠼ࡽࢀࡿᗄࡘ࠿ࡢᡤ
ぢࢆ⦪᩿ゎᯒ࡟ࡼࡾ᫂ࡽ࠿࡟ࡋࡓࠋ≉࡟ࠊձప➽ຊࡀ࣌ࣥࢺࢩࢪࣥୖ᪼
ࢆ௓ࡋ࡚⢭⚄⑓⑕≧ࡢࡦ࡜ࡘ࡛࠶ࡿᛮ⪃ࡢၥ㢟࡜㛵㐃ࡍࡿࡇ࡜ࠊղᛮ⪃ࡢၥ㢟ᑻᗘࢫࢥ࢔ࡀ㧗࠸ඣ❺࡛ࡣẟ㧥ள㖄⃰ᗘࡀ᭷ព࡟ప࠸ࡇ࡜ࠊճᒀ
୰ࡢศἪᑠ⬊࢚࢟ࢯࢯ࣮࣒࡟ໟྵࡉࢀࡓ6✀miRNAࡀ⢭⚄⑓య㦂ࡢᣢ⥆ࢆண ࡍࡿࡇ࡜ࢆぢฟࡋࠊሗ࿌ࡋࡓࠋ
ࡉࡽ࡟ࠊ࣌ࣥࢺࢩࢪࣥ⵳✚ࡀㄆࡵࡽࢀࡓ⤫ྜኻㄪ⑕ᝈ⪅ࡢ㑇ఏᏊゎᯒ࡟ࡼࡾࠊ᪂ࡓ࡞CNV/miRNAḞኻ࣭㔜」ࢆ᭷ࡍࡿ⑕౛ࢆぢฟࡋࠊሗ࿌ࡋ
ࡓࠋ

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㸦㠀ᖖ໅⫋ဨ㸧
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㔝ཎἨ
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㨣㢌⫱௦
⏣⏿ග୍

(2) ◊✲⪅ྡ㸦ᖖ໅⫋ဨ㸧
⣒ᕝᫀᡂ
ᇼෆὈỤ
㫽ᾏ࿴ஓ
▼⏣⿱᫛

(1) ◊✲ᮇ㛫
2020ᖺ4᭶㹼2025ᖺ3᭶
㸦5ᖺ㛫㸧

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸᪂஭ ㄔ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

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ࢼࣝࢥࣞࣉࢩ࣮Ⓨ⑕௬ㄝࠕ⮬ᕫච␿ᶵᗎ࡟ࡼࡿ࢜ࣞ࢟ࢩࣥ⚄⤒⣽⬊࠾ኚᛶࠖ࡟ࡘ࠸࡚ࠊCD4 ,CD8 T⣽⬊ࢆศྲྀࡋ⥙⨶ⓗDNA࣓ࢳࣝ໬ゎᯒࢆࡍࡍࡵࠊࢼࣝࢥࣞࣉࢩ࣮ࡢ㑇ఏᅉ࡜⎔ቃᅉࡢྠᐃࢆ⾜࠺ࠋ⑓ⓗ╀Ẽホ౯ἲ࡜ࡋ࡚╧╀₯᫬▷⦰࡟ຍ࠼⥲╧╀᫬㛫㑄ᘏࡀᐃ⩏ࡉࢀࡓࡀࠊධ╀᫬࣒ࣞ╧╀ᮇ࡞࡝᪂ᣦᶆࡢព⩏ࡢ᳨ウࢆࡍࡍࡵࠊ╀Ẽ࡟ࡘ࠸࡚ࡢ」ྜⓗᴫᛕࢆ᳨ド࣭ᥦၐࡍࡿࠋ⚄⤒Ⓨ㐩⑕࡜㐣╀⑕ྜే⑕౛࡟
࠾ࡅࡿ⏕⌮Ꮫⓗ࣭⏕໬Ꮫⓗᣦᶆࡢ≉ᚩࢆ᥈⣴ྠᐃࡋ㐣╀⑕ࡢࢧࣈࢱ࢖
ࣉ࡜ࡋ࡚఩⨨࡙ࡅࡿࠋ࢔ࢭࢳࣝࢥࣜࣥ⚄⤒࡜ࢭࣟࢺࢽࣥ⚄⤒࡟ࡼࡿ⤫ྜⓗ࡞⬻௦ㅰάືไᚚ
ࢆゎ᫂ࡋࠊ╧╀ぬ㓰ࡢ⚄⤒ไᚚࡢᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋࡲࡓ⚄⤒⣽⬊࡛ࡢ⣽⬊ෆATP⃰ᗘ᧯సἲࢆ☜❧ࡋࠊ࢚ࢿࣝࢠ࣮≧ែ࡟ࡼࡿ╧╀ぬ㓰ไᚚ(≉࡟࣒ࣞ╧╀᫬ࡢATPపୗ)ࡢᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ⏕⌮ⓗ࡞╧╀᮲௳ࡢゎ᫂ࢆ㏻ࡌ࡚Ⰻ㉁࡞╧╀ࡢ୍᪦ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼᪂ࡓ࡞ᣦᶆ࡜ࡋ࡚ᒀ୰MLT௦ㅰ≀㔞ࡀ╧╀ᣦᶆ࡜㛵㐃ࡍࡿࡇ࡜ࡶぢฟࡋࡓࠋICD11Ⓨຠ(2022.2)࡟క࠸᪂ࡓ࡟⊂❧❶࡜࡞ࡗࡓ╧╀ぬ㓰㞀ᐖศ㢮ࡢ
ᬑཬၨⓎࡢࡓࡵࡢ⤂௓ࢆ⾜ࡗࡓ ㄽᩥմ ࠋճ ࢚ࢿࣝࢠ࣮௦ㅰ࠿ࡽࡳࡓ╧╀ぬ㓰ไᚚࡢᇶ┙◊✲╧╀ぬ㓰≧ែ౫Ꮡⓗ࡞⚄⤒⣽⬊ෆATP⃰ᗘࡢኚືࡀ኱⬻⓶㉁඲య࡛ྠᮇ
ࡍࡿᶵᗎࡢ᳨ウࢆ㐍ࡵࡓࠋỗᛶᢞᑕᛶࡢࢭࣟࢺࢽࣥ⚄⤒⣔ࡢ㈿άࡀ࢔ࢫ
ࢺࣟࢧ࢖ࢺࡢάᛶ໬(cAMPୖ᪼ࠊCaቑຍ)࡜ࢢࣜࢥ࣮ࢤࣥศゎࢆࡶࡓࡽࡋ
⚄⤒⣽⬊࡬ங㓟ࡀ౪⤥ࡉࢀࡿࡇ࡜ࢆሗ࿌࡛ࡁࡓࠋ ㄽᩥճ ࢔ࢫࢺࣟࢧ࢖ࢺ㈿ά࡟ࡣ࢔ࢭࢳࣝࢥࣜࣥ⚄⤒ࡢᐤ୚ࡶᚲせ࡜ぢฟࡋࡓࠋ࣭ ୰ᯡᛶ㐣╀⑕ࡢࡦ࡜ࡘ࡛࠶ࡿ≉Ⓨᛶ㐣╀⑕ࡣࠊᐙ᪘ෆⓎ⑕ࡀከ࠸ࡀ㑇ఏᅉ୙᫂ࠋ㐺ษ࡞⑓ែᣦᶆࡀᮍ☜❧࡛ࠊ᭷ຠ࡞἞⒪ἲ࡟ஈࡋ࠸ၥ㢟ࡀ࠶ࡿࠋᅜෆከ᪋タඹྠ◊✲࡛ከᩘ⑕౛ࢆᑐ㇟࡜ࡋࡓG AS࡛ࡣࢤࣀ࣒࣡࢖ࢻ᭷ព࡞⑌ᝈ㛵㐃㑇ఏᏊࢆྠᐃ࡛ࡁ࡞࠿ࡗࡓࡀࠊࣞ࢔ࣂࣜ࢔ࣥࢺ᥈⣴࡛≉Ⓨᛶ㐣╀⑕ࡢཎᅉ㑇ఏᏊࢆึࡵ࡚ྠᐃࡋࡓ ㄽᩥձ ࠋ࣭ ࢼࣝࢥࣞࣉࢩ࣮࡟≉␗ⓗ࡜ᛮࢃࢀࡓ࢜ࣞ࢟ࢩࣥ๓㥑యࡢcleavage siteࡢ୍ሷᇶ⨨᥮ࡀ≉Ⓨᛶ㐣╀⑕࡟ࡶ㛵㐃ࡍࡿ࡜࠸࠺ពእ࡞Ⓨぢ࡛࠶ࡿࠋ௨๓ࡼࡾᥦၐࡋ
࡚࠸ࡿࢼࣝࢥࣞࣉࢩ࣮࡜㛵㐃㐣╀⑕࡟࠾ࡅࡿ⬡⫫㓟௦ㅰ␗ᖖ࡟ࡘ࠸࡚RNAseq࡛ࡶ⬡⫫㓟௦ㅰ㛵㐃㑇ఏᏊࡀぢฟࡉࢀࠊ࢔ࢩࣝ࢝ࣝࢽࢳࣥࡀ㐣╀⑕ࡢ᪂ࡓ࡞
⑓ែᣦᶆ࡛࠶ࡿࡇ࡜ࢆሗ࿌࡛ࡁࡓ ㄽᩥղ࣭ HLA㑇ఏᏊ࡜ࢼࣝࢥࣞࣉࢩ࣮⑓ែࡢ㛵㐃ࡣ㛗ᖺᮍゎ࡛᫂࠶ࡿࡀࠊ࣓ࢳࣝ໬࡜
RNAseqゎᯒ࡟ࡼࡾࠊࡶ࠺୍ࡘࡢHLA࢔ࣜࣝࡢⓎ⌧㔞ࢆኚ໬ࡉࡏࡿࡇ࡜ࢆぢฟࡋࡓࠋ୺ほⓗ╀Ẽࡢ㐺ษ࡞ホ౯ἲղ୰ᯡᛶ㐣╀⑕ࡢ⏕≀ᣦᶆࡢ᥈⣴ྠᐃ✲       ᡂ
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㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾࢩࢽ࢔◊✲ဨඣ⋢ ஽ᒸᡞᬕ⏕ᐇ㦂⿵ຓဨྵእ㒊ᨭ᥼ 
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㠀ᖖ໅◊✲ဨྵእ㒊ᨭ᥼ Ḓ ⚽⌋㸦ࢡ࢛ࣥ ࢫࢪࣥ㸧༠ຊ◊✲ဨ ᔱከ⨾✑Ꮚᇶ┙ᢏ⾡◊✲ဨ ᑠᓥ ᓫ(2) ◊✲⪅ྡ
ᐑᕝ ༟
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(1) ◊✲ᮇ㛫
2020ᖺ4᭶䡚2025ᖺ3᭶
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╧╀㞀ᐖࡢ⑓ᅉ࣭⑓ែゎ᫂࡜἞⒪ἲࡢ㛤Ⓨ㸭╧╀ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᮏከ ┿㸧(1)ᅜෆእࡢ◊✲≧ἣᅜ㝿⤫ྜ╧╀་⛉Ꮫ◊✲ᶵᵓ࡛ࡣ࣐࢘ࢫ࡛ࡢ኱つᶍmutagenesis◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࡋ࠿ࡋ࣐࢘ࢫ࡟ࡣ╧╀࡜ぬ㓰ࡢࡳࡀ࠶ࡾࠕ╀Ẽࠖࢆ༊ู࡛ࡁ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ⮫ᗋ⑕౛ࢆฟⓎⅬ࡜ࡋ⮫ᗋ᳨య ղࢆ⏝࠸ࡓゎᯒ࡜⑕≧/╧╀᳨ᰝᣦᶆ࡜ࡢ㛵㐃࡟ᇶ࡙ࡁࠊከඖᛶࢆࡶ
ࡘ╀Ẽࡢ⑓ែᣦᶆࢆ᥈⣴ྠᐃࡋࠊ⮫ᗋ⌧ሙ࡟㑏ඖࡍࡿయไࢆ࡜ࡿࠋ
ᅜෆᒅᣦࡢ㐣╀⑕እ᮶/Ⓨ㐩እ᮶ࢆࡶࡘᬕ࿴⑓㝔/ᑠ▼ᕝᮾி⑓㝔࡜ࡢᐦ᥋࡞ඹྠ◊✲࡛950௨ୖࡢ⑕౛⵳✚ࡀ᏶஢ࠊ᪥ᮏே㞟ᅋ࡛ࡢ⏕ճ≀ᣦᶆ࣭⑓ែᣦᶆࡸ㑇ఏᅉ⎔ቃᅉࡢ᳨ウࡀྍ⬟࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓ╧╀ぬ㓰ࡢ⚄⤒ᶵᵓࢆᨭ࠼ࡿ⚄⤒⣽⬊ࡢ࢚ࢿࣝࢠ࣮≧ែ࡟ࡘ࠸࡚ࠊ⚄⤒⣽⬊ෆATP⃰ᗘࡢin vivoࣜ࢔ࣝࢱ࢖࣒ィ ἲࢆά⏝ࡋࠊୡ⏺࡟ඛ㥑ࡅ࡚╧╀ไᚚࡢ௦ㅰᇶ┙ࢆゎ᫂ࡋ࡚࠸ࡿࠋ

(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ձMiyagawa T,-- Honda M. A rare genetic variant in the cleavage site of
prepro-orexin is associated with idiopathic hypersomnia. NPJ Genomic
Medicine, 7: 29-29. doi: 10.1038/s41525-022-00298-w 2022/04/12
ղHonda M,-- Miyagawa T. Low carnitine palmitoyltransferase1 activity
is a risk factor for narcolepsy type 1 and other hypersomnia. Sleep, doi:
10.1093/sleep/zsac160 2022/07/10
ճNatsubori A,-- Honda M. Serotonergic neurons control cortical neuronal
intracellular energy dynamics by modulating astrocyte-neuron lactate
shuttle iScience, 26:105830, 2023 doi: 10.1016/j.isci.2022.105830
մᮏከ┿㸸 ╧╀࣭ぬ㓰㞀ᐖ(Sleep-wake Disorders) ICD-11ศ㢮࡜⑓ྡゎㄝࢩ࣮ࣜࢬྛㄽ12 ⢭⚄⤒ㄅ124: 192-197,2022.

(1) ᴫせ⌧௦♫఍࡛ࡣ⏕άᵝᘧࡸປാࡢ㉁ⓗኚ໬࠿ࡽ╧╀㞀ᐖࡀቑຍࡋ࡚
࠸ࡿࠋ╧╀㞀ᐖࡢ᪥ᖖ࣭♫఍⏕άୖ࡛ࡢ᭱኱ࡢၥ㢟ࡣ╀Ẽ࡟క࠺ㄆ▱ᶵ⬟పୗ࡛࠶ࡾࠊຠ⋡పୗࡸ⏘ᴗ஦ᨾࡣⳘ኱࡞♫఍⤒῭ⓗᦆኻ(᥎ᐃ15඙෇/ᖺ)ࢆࡶࡓࡽࡍࠋࡋ࠿ࡋ㔜⠜࡞ OL㞀ᐖࢆక࠺୰ᯡᛶ㐣╀⑕ࡢデ᩿ࡣ㐜ࢀࡀࡕ࡛᰿἞⒪ἲࡶ࡞࠸ࠋᮏ◊✲࡛ࡣ᪥ᮏே࡟ከ࠸
㐣╀⑕ࡢ㑇ఏᏊゎᯒ࡜ᶵ⬟᳨ウ࠿ࡽ⑓ᅉゎ᫂ࢆ⾜࠺࡜࡜ࡶ࡟ࠊ⑓ែ
ᣦᶆࡸ⑓ⓗ╀Ẽุᐃἲࢆ☜❧ࡋࠊ㐺ษ࡞デ᩿ศ㢮ᥦၐ࡜ᬑཬၨⓎࢆ⾜࠺ࠋࡲࡓ⬻ෆ࢚ࢿࣝࢠ࣮௦ㅰ࡜╧╀ぬ㓰≧ែ࡜ࡢ㛵㐃࠿ࡽ╧╀ぬ㓰ไᚚࡢ௦ㅰᇶ┙ࢆゎ᫂ࡋࠊ╧╀ࡢ⌮ゎ࡜╧╀ᨵၿἲ㛤Ⓨ࡟⤖ࡧࡘࡅࡿࠋ୺࡞◊✲ᡂᯝ

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࣭ ࠺ࡘ⑓ࡸ⤫ྜኻㄪ⑕ࠊࡲࡓADHDࠊASD࡞࡝ࡢⓎ㐩㞀ᐖࡢ⑓ែ࣓࢝
ࢽࢬ࣒ࡢゎ᫂ࢆ㐍ࡵࠊ᪂つ἞⒪ἲ࠾ࡼࡧண㜵ἲࡢᥦ᱌ࢆ┠ᣦࡍࠋࡀࠊᅜࡈ࡜ࡢၥ㢟ࡢ㐪࠸ࡸ౫Ꮡᛶ≀㉁࡟ᑐࡍࡿឤཷᛶࡢே✀ᕪ࡞࡝ࡀ࠶ࡾࠊᮏ㑥࡛ࡢၥ㢟ࡢゎỴ࡟ࡣ⮳ࡗ࡚࠸࡞࠸ࠋ≉(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࡟ࠊ୰ᯡ่⃭⸆౫Ꮡ࡟ᑐࡍࡿ἞⒪⸆ࡣୡ⏺ⓗ࡟࡞࠸ࠋ㙠③࡟ ձ ⸆≀౫Ꮡ◊✲㛵ࡋ࡚ࡣࠊಶู໬་⒪ࡢ㔜せᛶࡸᐇ⌧ᛶࡀୡ⏺ⓗ࡟㧗ࡲࡗ࡚ ࣭ ᙜࣉࣟࢪ࢙ࢡࢺࡀ୰ᚰ࡜࡞ࡗ࡚᪥ᮏᏛ⾡఍㆟࢔ࢹ࢕ࢡࢩࣙࣥศ⛉఍࠾ࡾࠊ୰࡛ࡶࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࡢ◊✲ࡣࠊᙜ◊✲ࢢࣝࡢάືࢆ㐍ࡵ࡚࠸ࡿࠋぬ㓰๣౫Ꮡ⑕἞⒪⸆ࡢ㛤Ⓨࡸࢠࣕࣥࣈࣝ㞀ᐖ࣮ࣉࡀୡ⏺ࢆ≌ᘬࡋ࡚࠸ࡿࠋ㛵㐃⢭⚄⚄⤒⑌ᝈ◊✲࡟࠾࠸࡚ࡢື≀ࣔࢹࣝࡀసฟࡉࢀࡿィ⏬࡛࠶ࡿࠋࡣࠊື≀ᐇ㦂࡜⮫ᗋ◊✲ࡣ⼥ྜⓗ࡞ᒎ㛤࡟ࡣ࡞ࡗ࡚࠸࡞࠸ࠋ ղ 㙠③◊✲≉࡟ࠊ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕(ASD)ࡢ୰ᚰ⑕≧ࡢ἞⒪⸆ࡣୡ⏺ⓗ ࣭ ࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࢆ㛤ጞࡋ࡚࠸ࡿࡢ࡛ࠊ௒ᚋࡣࡑࡢᨵⰋࡸᣑ
኱ࡀᮇᚅ࡛ࡁࡿࠋᘬࡁ⥆ࡁ㛵㐃㑇ఏᏊከᆺࢆぢฟࡍィ⏬࡛࠶ࡿࠋ࡟ࡶࡲࡔ࡞ࡃࠊ㞴἞ᛶ࠺ࡘ⑓࡟἞⒪ຠᯝࡢ࠶ࡿࢣࢱ࣑ࣥࡢసճ 㛵㐃⢭⚄⚄⤒⑌ᝈ◊✲⏝ᶵᗎࡶ୙࡛᫂࠶ࡾࠊ◊✲㛤Ⓨࡀồࡵࡽࢀ࡚࠸ࡿࠋ

(1)㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊✲ᮇ㛫(2) ◊✲⪅ྡụ⏣࿴㝯ࠊ஭ᡭ⪽୍㑻ࠊ➟஭ៅஓࠊ⸨⏣㞞௦ࠊす⃝኱㍜ࠊ኱ᒸ㟼⾰ࠊྂ⏣ᓥᾈᏊࠊⴗ㔝ὒᏊࠊ᳃ᒇ
⏤⣖ࠊ㟷ᮌㅬ඾ࠊኳ㔝ຌ஧㑻ࠊ᯽஭ὒᩥࠊ኱㇂ಖ࿴ࠊ㛗㇂ᕝ‽Ꮚࠊடࣨ㇂ᝋᏊࠊ୰ᒣிᏊࠊỤ⏿⿱Ꮚࠊᯇᓥ⏤⣖Ꮚࠊ⏣୰⨾Ṍࠊ㧗ᶫ㤶ኸ㔛ࠊụ❑⤖Ꮚࠊሯᮏṇኴ㑻ࠊ஭ୖ⌮ᜨࠊᑠᓮⰾᙪࠊⴠྜ㑳⣖Ꮚࠊῧ⏣ ⴌࠊ⩏㑣᭷ᙬࠊᇼ Ᏻ⳯ࠊຍ⸨႐ஂࠊᒾୗ ྡྂ ⏤ెࠊᯇᒣᑦᶟࠊᒣᓊឡᐇࠊ᳃஭㞞Ꮚࠊᒣཱྀಖᬕࠊ⯆ὠ㞞ேࠊ㒟 Ợ⍧ࠊ୸ᒣ㱟அ௓ࠊ᪂஭⏣ᝡࠊጧ⿱ዉࠊ┦⏣Ⳁዉࠊ᳃ᮏ᲍ࠎⰼࠊ
/HD %DXPDQQࠊᱵᮧ஧ⴥࠊᮧᒸ
Ώࠊబ⸨ᩔᚿࠊᒾ⏣ ೺ࠊཎཱྀᙬ
Ꮚࠊᖹ἟ᙬᏊࠊྜྷ⏣㤶⧊ࠊ୰ᮏⓒྜỤࠊ᳃㔝ⰋⶶࠊᏱ㔝ᜤ௓ࠊᴋ஭ඃ㤶ࠊᐑす ⫕ࠊἨᑿ┤Ꮥࠊὸ㔝᫡ᚿࠊ⸨஭ᣅ☻ࠊబࠎᮌ୍┈ࠊᇼᒸᕼ⾰ࠊ⥴᪉ඖẼࠊᒣᮏ೺୍
ࠊෆ㔝ⱱኵࠊᑠᯘ ᚭࠊྜྷ஭ගಙ
ࠊ᭮Ⰻ୍㑻ࠊᒾᶫ࿴ᙪࠊᯘ⏣┾࿴ࠊᵽཱྀ 㐍ࠊ⚟⏣ㅬ୍ࠊጒᑿᰤ୍ࠊᱵ㔝 ඘ࠊụ⏣᭸ᗈࠊ኱஭୍
㧗ࠊᘅ୰┤⾜ࠊᯇୗᖾ⏕2020ᖺ4᭶䡚2025ᖺ3᭶
㸦5ᖺ㛫㸧

(1)

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౫Ꮡᛶ≀㉁ࡢస⏝ᶵᗎゎ᫂࡜ࡑࡢ་⒪ᛂ⏝㸭౫Ꮡᛶ≀㉁ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ụ⏣࿴㝯㸧(1) ᡂᯝࡢᴫせձ ⸆≀౫Ꮡ◊✲࣭ GIRKࢳࣕࢿࣝ࡟㑇ఏᏊኚ␗ࢆᣢࡘ࢘࢕࣮ࣂ࣮࣐࢘ࢫ࡛ࠊぬ㓰๣Ⴔዲᛶࡢᾘኻ࡞࡝ࢆぢฟࡋࡓࠋࡲࡓࠊGIRKࢳࣕࢿࣝ㜼ᐖ⬟ࢆ᭷ࡍࡿ࢖ࣇ
࢙ࣥࣉࣟࢪࣝࡢぬ㓰๣౫Ꮡ἞⒪ຠᯝࢆࣉࣛࢭ࣎ᑐ↷஧㔜┣᳨ヨ㦂࡟ࡼࡗ୍࡚㒊᫂ࡽ࠿࡟ࡋࡓࠋ࣭ ⥺⹸ࡀࣔࣝࣄࢿႴዲᛶࢆ♧ࡍࡇ࡜࡞࡝ࢆぢฟࡋࡓࠋ࣭ ࢻ࣮ࣃ࣑ࣥࢆḞஈࡉࡏࡓ࣐࢘ࢫࢆゎᯒࡋࠊ㐠ືஹ㐍ࡢ㝿࡟ࡣࠊᾏ㤿⚄⤒⣽⬊ࡀ≉␗ⓗ࡟άືࡋ࡚࠸ࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ 㯞⸆࡛࠶ࡿ5-MeO-DIPTࡢస⏝ᶵᗎࢆぢฟࡋࡓࠋ࣭ ᮍᡂᖺ⪅࡟࠾࠸࡚ࠊࢤ࣮࣒ㄢ㔠ไᗘࡢၥ㢟ࢆぢฟࡋࡓࠋղ 㙠③◊✲(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ ⑊③ឤཷᛶ࠾ࡼࡧ㙠③⸆ឤཷᛶ࡜㛵㐃ࡍࡿ㑇ఏᏊከᆺ࡜ࡋ࡚ࠊPAR2,
࣭ Ide et al. Int J Mol Sci. 24(4):3351 (2022)
TRPM8, ASTN2, SCN9A, LPAR1, HS3ST4, CNR1, SLC17A9, P2RY12,
࣭ Kashii et al. Hum Genomics in press.
C3orf20, TRPC3ࡢ㑇ఏᏊከᆺࢆぢฟࡋࡓࠋ࡞࡝ࠊཎⴭㄽᩥ47௳ࠊ⥲ㄝ➼20௳ࠊᏛ఍Ⓨ⾲࣭ㅮ₇➼122௳ ࣭ 㟁Ẽ②ᨥ⒪ἲ࡟ࡼࡗ࡚ࣔࣝࣄࢿ㙠③ຠᯝࡀቑᙉࡍࡿ࣓࢝ࢽࢬ࣒ࢆື
㸦2020-2022ᖺᗘ㸧≀ᐇ㦂࡟ࡼࡾ᫂ࡽ࠿࡟ࡋࡓࠋճ 㛵㐃⢭⚄⚄⤒⑌ᝈ◊✲࣭ ⤫ྜኻㄪ⑕ᝈ⪅࡛ࡢႚ↮ࡸ௚ࡢ⢭⚄⑌ᝈ࡜ࡢ㛵ಀࢆ࣏ࣜࢪ࢙ࢽࢵࢡ
(3) ᅜෆእࡢ◊✲≧ἣࣜࢫࢡࢫࢥ࢔ゎᯒ࡟ࡼࡾ᫂ࡽ࠿࡟ࡋࡓࠋ⫾⏕ᮇࡢࣆࢡࣟࢺ࢟ࢩࣥᭀ
⸆≀౫Ꮡ࡟㛵ࡋ࡚ࡣࠊ࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇ᇶᮏἲࠊࢠ
㟢ࡀASDᵝ⾜ືࢆᘬࡁ㉳ࡇࡍࡇ࡜ࢆぢฟࡋࡓࠋASDࣔࢹࣝື≀࡛࠶ࣕࣥࣈࣝ➼౫Ꮡ⑕ᑐ⟇ᇶᮏἲࡀ᪋⾜ࡉࢀࡓࡀࠊᅜෆ࡛ࡢ◊✲ࡿTSC1࠾ࡼࡧTSC2ࡢ࣊ࢸࣟḞᦆ࣐࢘ࢫ࡟ຍ࠼ࠊࢲࣈࣝ࣊ࢸ࣐ࣟ࢘
ࡣ୙༑ศ࡛࠶ࡿࠋᅜእ࡛ࡣ኱つᶍ࡞◊✲㈝ࡀᢞࡌࡽࢀ࡚࠸ࡿࢫࢆస〇ࡋ࡚ࠊTSC2ศᏊࡢᙺ๭ࡢ኱ࡁࡉࢆぢฟࡋࡓࠋ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᴫせ౫Ꮡᛶ≀㉁ࡢస⏝ᶵᗎࢆゎ᫂ࡍࡿࡇ࡜࡛ࠊ౫Ꮡᛶ≀㉁ࡢ᭷
ᐖᛶ࡜ࡋ࡚⸆≀౫Ꮡࡢ◊✲ࠊ᭷⏝ᛶ࡜ࡋ࡚㙠③࠾ࡼࡧⓎ㐩㞀ᐖ࣭࠺ࡘ⑓࡞࡝ࡢ㛵㐃⢭⚄⚄⤒⑌ᝈࡢ἞⒪࡟㛵ࡍࡿ◊✲ࢆ㐍ࡵࡓࠋලయⓗ࡟ࡣࠊࠕ⸆≀౫Ꮡ἞⒪ἲ࠾ࡼࡧண㜵ἲࡢᥦ᱌ࠖࠊࠕࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ἲࡢᐇ⌧ࠖࠊࠕ᪂つ἞⒪ἲࡢᥦ᱌ࠖ࡜࠸࠺ࠊ3ࡘࡢ᫂☜࡞♫఍㑏ඖ࡛ࣞ࣋ࣝࡢ┠ᶆࢆタᐃࡋࠊศᏊࣞ࣋ࣝࠊື≀ࣞ࣋ࣝࠊࣄࢺࣞ࣋ࣝࠊ♫఍㑏ඖࣞ࣋ࣝࡢ◊✲ࢆ᭷ᶵⓗ࡟Ⓨᒎࡉࡏࡓࠋ

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㸸COVID-19ࡣ௒ᚋࡶᣢ⥆ࡋ࡚࠸ࡃࡇ࡜ࡀ᝿ᐃࡉࢀࡿࠋ
⌧⾜࣡ࢡࢳࣥࡼࡾࡶ๪཯ᛂࡀᑡ࡞ࡃࠊᗂඣ࠿ࡽ⪁ேࡲ࡛ࡀᏳᚰࡋ
࡚᥋✀࡛ࡁࠊ࠿ࡘຠᯝࡀࡼࡾ㛗ᮇ㛫ᣢ⥆ᛶࡍࡿ࣡ࢡࢳࣥࡢ㛤Ⓨࢆ┠ᣦࡋࠊ㧗ᗘᙅẘ໬࣡ࢡࢩࢽ࢔࢘࢖ࣝࢫ࣋ࢡࢱ࣮࣡ࢡࢳࣥࢆ⏘Ꮫ㐃ᦠయไ࡛㛤Ⓨࡋ࡚࠸ࡿࠋ៏ᛶ⫢⑌ᝈ㸸἞⒪⸆ࡢ㛤Ⓨࡀᛴົ࡛࠶
ࡿ⫢◳ኚ࡟ᑐࡋ࡚ࠊ⥺⥔໬ᢚไࠊ⥺⥔ศゎࠊ࡞ࡽࡧ࡟⫢⣽⬊ᶵ⬟ᅇ᚟ࢆ♧ࡍ᪂つ἞⒪⸆ࡢ⮫ᗋᛂ⏝࡟ྥࡅ࡚ࠊ་ᖌ୺ᑟ἞㦂ࡢᐇ᪋࡜ඹ࡟ࠊ⸆๣ࡢస⏝ᶵᗎゎᯒࠊ㠀౵くᛶࡢ἞⒪ホ౯࣐࣮࣮࢝ࡢ᥈
⣴ࢆ㐍ࡵ࡚࠸ࡿࠋࢹࣥࢢ⇕㸸⌧ᅾㄆྍࡉࢀ࡚࠸ࡿࢹࣥࢢ⇕࣡ࢡࢳ࡛ࣥၥ㢟࡜࡞ࡗ࡚࠸ࡿᢠయ౫Ꮡᛶឤᰁቑᙉຠᯝ㸦ADE㸧ࢆ♧ࡉ࡞࠸ࠊ⣽⬊ᛶච␿ㄏᑟࢆ୺య࡜ࡋࡓ᪂つ࣡ࢡࢳࣥࡢ㛤Ⓨࢆ」ᩘࡢ◊✲ᶵ㛵࡜ඹ࡟㐍ࡵ࡚࠸ࡿࠋ

Ꮫ఍㸸 Ᏻ஭ᩥᙪࡽ ➨ᅇ᪥ᮏ࣡ࢡࢳࣥᏛ఍Ꮫ⾡㞟఍  Ᏻ஭ᩥᙪࡽ ➨ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍   ᮏ⏣ᬛᏊࡽ ➨ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ ᯇᮏ♸௓ࡽ ➨ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍   ᒣᮏ┤ᶞࡽ ➨ᅇ᪥ᮏ࢘࢖
ࣝࢫᏛ఍Ꮫ⾡㞟఍   Ჷ᪉⩼ࡽ ➨ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ
⾡㞟఍   Ᏻ஭ᩥᙪࡽ ➨ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍Ꮫ⾡㞟఍㸦ᣍᚅㅮ₇㸧 ᒣᮏ┤ᶞࡽ ➨ᅇ᪥ᮏ⫢⮚Ꮫ఍኱఍㸦ࢩ࣏ࣥ
ࢪ࣒࢘ㅮ₇㸧ㄽᩥ㸸1) Otsubo N, et al. BMC Endocr Disord. 2023 3(1):5, 2) Sanada
T, et al. J Infect Chemother. 2022 S1341-321 (22)00335- , 3) Inuo
E, et al. Psychiatry Clin Neurosci. 2022, 4) Ishigaki H, et al. Front
Microbiol. 2022 13:967019, 5) ҈Ҭชඛ พ࡯ ҫָ͹͍ΑΊ111ʷ
118, 2022

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ຠᯝⓗ࡞ண㜵ἲࡸ἞⒪ἲࡀ㛤Ⓨࡉࢀ࡚࠸࡞࠸㞴἞ᛶ࢘࢖ࣝࢫឤ
ᰁ⑕ࡣࠊ་⒪యไࡀᩚഛࡉࢀ࡚࠸ࡿඛ㐍ㅖᅜ࡟࠾࠸࡚ࡶ⏒኱࡞⿕ᐖࢆࡶࡓࡽࡍࠋᮏ◊✲ㄢ㢟࡛ࡣࠊCOVID-19ࠊࢹࣥࢢ⇕ࠊ㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨࠊᛴᛶ⫢⑌ᝈ㸦Aᆺ⫢⅖࢘࢖ࣝࢫឤᰁ⑕㸧ཬࡧ៏ᛶ⫢⑌ᝈ㸦Bᆺ࣭Cᆺ⫢⅖࢘࢖ࣝࢫឤᰁ⑕࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫⫢⅖㸧ࡢⓎ⑕࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋࠊᏳ඲࠿ࡘ᭷ຠ࡞἞⒪ཬࡧண㜵ἲࡢ☜❧ࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ 㸦㸰㸧௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ᗈᇦ஺ᕪ㜵ᚚຠᯝࢆ♧ࡍrDIs-Sࡢస⏝ᶵᗎࢆ᫂ࡽ࠿࡟ࡋࠊᮏ࣡ࢡࢳ
ࣥೃ⿵ࡢ᭷⏝ᛶࢆ♧ࡍࠋ࣡ࢡࢳࣥ᥋✀⪅ࡢᢠయ౯ㄪᰝ࡛ࡣࠊᘬࡁ⥆ࡁCOVID-19ឤᰁὶ⾜࡜ᢠయ౯ࡢ┦㛵ᛶࡢゎᯒࢆ㐍ࡵࡿࠋ࣭ ⫢⥺⥔⑕἞⒪⸆ೃ⿵PRI-724ࡀ♧ࡍస⏝ࡢࡼࡾヲ⣽࡞ᶵᗎࡢゎ᫂ࢆ┠
ᣦࡍࠋHBV἞⒪⸆ೃ⿵ࡢస⏝ᶵᗎࢆヲ⣽࡟ゎᯒࡍࡿࠋ࣭ ᪂つࢹࣥࢢ࣡ࢡࢳࣥࡢ㜵ᚚຠᯝࢆ㟋㛗㢮ࣔࢹ᳨࡛ࣝドࡍࡿࠋ㸦㸯㸧ᡂᯝࡢᴫせձ CI࣭㧗ᗘᙅẘ໬࣡ࢡࢩࢽ࢔࢘࢖ࣝࢫDIsᰴࢆ࣋ࢡࢱ࣮࡜ࡋࡓSࢱࣥࣃࢡ㉁Ⓨ⌧࣡ࢡࢳࣥ㸦rDIs-S㸧ࡀᅜෆὶ⾜ᰴ࡛࠶ࡗࡓ࣑࢜ࢡࣟࣥᰴBA.1ཬࡧ
BA.5࡟ᑐࡋ࡚ண㜵ຠᯝࢆ♧ࡍࡇ࡜ࢆ࣐࢘ࢫࣔࢹ࡛ࣝ☜ㄆࡋࡓࠋ᭦࡟ࠊ
ࡑࡢண㜵ຠᯝࡣ࣡ࢡࢳࣥ᥋✀ᚋ1ᖺ௨ୖᣢ⥆ࡍࡿࡇ࡜ࡀุ᫂ࡋࠊ⌧⾜࣡ࢡࢳ࡛ࣥၥ㢟࡜࡞ࡗ࡚࠸ࡿච␿ᛂ⟅ࡢపୗࢆඞ᭹࡛ࡁࡿྍ⬟ᛶࡀ♧ࡉࢀࡓ(Front Microbiol.㸦2022㸧࡟Ⓨ⾲)ࠋ
࣭㒔❧⑓㝔ࡢ༠ຊࡢࡶ࡜ࠊ་⒪ᚑ஦⪅ࢆᑐ㇟࡟࣡ࢡࢳࣥ3ᅇ┠ཬࡧ4ᅇ┠᥋✀ᚋࡢᢠయᛂ⟅ࢆゎᯒࡋࡓࠋ࣡ࢡࢳࣥ3ᅇ┠᥋✀7ࣧ᭶ᚋࡢᗄఱᖹᆒᢠ
య౯ࡣࠊ3ᅇ┠᥋✀4ࣧ᭶ᚋ࡜ẚ㍑ࡋࡓሙྜ࡟ࡣ᭷ព࡞పୗࡀࡳࡽࢀࡓ
ࡀࠊ࣡ࢡࢳࣥ2ᅇ┠᥋✀7ࣧ᭶ᚋ࡜ẚ㍑ࡋࡓ㝿࡟ࡣ᭷ព࡟㧗ࡃࠊ3ᅇ┠ࢆ᥋✀ࡍࡿࡇ࡜࡛ᢠయ౯ࢆࡼࡾ㧗ࡃ⥔ᣢ࡛ࡁࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋ᭦࡟ࠊ4ᅇ┠ࡢ᥋✀⪅࡛ࡣࠊ㠀᥋✀⪅࡜ẚ࡭࡚ᢠSᢠయ౯࣭୰࿴ᢠయ౯࡜ࡶ࡟᭷
ព࡟㧗್࡛࠶ࡾࠊᐃᮇⓗ࡞㏣ຍ᥋✀ࡣᢠయ౯ࢆ㧗ࡃ⥔ᣢࡍࡿࡇ࡜࡟᭷ຠ
࡛࠶ࡿࡇ࡜ࡀ♧ࡉࢀࡓ㸦J Infect Chemother. (2022)࡟Ⓨ⾲㸧ࠋղ ⫢⅖࣭㑅ᢥⓗ nt/ȕ-catenin/CBPࢩࢢࢼࣝ㜼ᐖ๣PRI-724ࡢᏳ඲ᛶ࡜᭷ຠᛶࢆホ౯ࡍࡿࡓࡵ࡟ࠊCᆺࡲࡓࡣBᆺ⫢◳ኚᝈ⪅ࢆᑐ㇟࡜ࡋࡓ་ᖌ୺ᑟ࡟ࡼࡿከ᪋タඹྠࡢ࣮࢜ࣉࣥࣛ࣋ࣝ㠀ࣛࣥࢲ࣒໬ẚ㍑➨I/ IIaヨ㦂㸦ᅜෆ3
᪋タࠊ➨I┦:15ྡࠊ➨IIa┦:15ྡ㸧ࡀᐇ᪋ࡉࢀࡓࠋPRI-724ᢞ୚࡟ࡼࡾ
FibroScan࡛ ᐃࡋࡓ⫢◳ᗘࡢ᭷ព࡞పୗ࡜Child-Pughศ㢮ࡀBࡢ2౛ࡢ⿕㦂⪅࡛A࡬ࡢᨵၿࡀㄆࡵࡽࢀࡓࠋ
࣭ Bᆺ⫢⅖࢘࢖ࣝࢫ㸦HBV㸧࡟ᑐࡍࡿ᪂つ἞⒪⸆ࡢ㛤Ⓨࢆ┠ᣦࡋࠊ⫢⣽⬊ᣦྥᛶ⬡㉁࣏ࣜ⢏Ꮚ࡛࠶ࡿGalNAc-LNP࡟⮬↛ච␿ࢆㄏᑟࡍࡿpICࢆ
ᑒධࡋࡓGalNAc-LNP/pICࢆ⏝࠸࡚ࠊHBVᣢ⥆ឤᰁࣄࢺ⫢⮚࣓࣐࢟ࣛ࢘ࢫ࡛἞⒪ຠᯝࢆ᳨ウࡋࠊ⫢⮚୰cccDNAࡢῶᑡࡀ☜ㄆ࡛ࡁࡓࠋճ ࢹࣥࢢ⇕࣭᪂つࢹࣥࢢ⇕࣡ࢡࢳࣥࡢ㛤Ⓨ㸸 T⣽⬊ㄏᑟᆺ࣡ࢡࢳࣥ࡜ࡋ࡚సฟࡋ
ࡓrDIs-N25-GND࣡ࢡࢳࣥࡢ᭷ຠࢆ࣐࢘ࢫࣔࢹ࡛ࣝ☜ㄆ࡛ࡁࡓࠋ◊       ✲       ᡂ       ᯝ(2) ◊✲⪅ྡ
Ᏻ஭ᩥᙪ
ᑠཎ㐨ἲ
Ჷ᪉ ⩼
ᒣ᰿኱඾
ᒣᆅ㈼୕㑻
ᒣᮏ┤ᶞ
┿⏣ᓫᘯ
ᯇᮏ♸௓
ᮏ⏣ᬛᏊ
Ἑ㔝ࡾࡉ
㧗ᮌᮅᏊ
ẚ჆㞞ᙪ
እᒣဏ⣖Ꮚ
ྂ㛵ᩥ

(1)

◊✲ᮇ㛫
2020ᖺ4᭶䡚2025ᖺ3᭶
㸦5ᖺ㛫㸧

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸Ᏻ஭ᩥᙪ㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－ 1－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠụ

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࢘࢖ࣝࢫ」〇ᶵᵓࡢゎ᫂࡜࣡ࢡࢳࣥࡢ㛤Ⓨ㸭࢘࢖ࣝࢫឤᰁࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ(1)(1) ◊✲ᮇ㛫(1) ᡂᯝࡢᴫせᴫせ࢚ ࣥ ࢸ ࣟ ࢘ ࢖ ࣝ ࢫ 71(EV71) ࠊ ࢥ ࢡ ࢧ ࢵ ࢟ ࣮ ࢘ ࢖ ࣝ ࢫ ࣭ ᪥ᮏᅜෆ࡛ศ㞳ࡉࢀࡓEV71ᰴࠊ࣋ࢺࢼ࣒࡛ศ㞳ࡉࢀࡓ 2020ᖺ4᭶䡚2025ᖺ3᭶
㸦5ᖺ㛫㸧
EV71ᰴࢆSCARB2 tg࣐࢘ࢫ࡟᥋✀ࡍࡿࡇ࡜࡟ࡼࡾẘຊࢆホ
A6(CVA6)࡞࡝࡞࡝ᛴᛶࡢ࢘࢖ࣝࢫឤᰁ⑕ࡢ」〇ᶵᵓࠊ⑓౯ࡋࡓࠋὶ⾜ᖺࡸὶ⾜ᆅࡈ࡜࡟⑓ཎᛶࡀኚ໬ࡋ࡚࠸ࡿࡇ࡜ (2) ◊✲⪅ྡ
ཎᛶⓎ⌧ᶵᵓࢆㄪ࡭ࡿࠋࡑࡢ▱ぢࢆඖ࡟ឤᰁື≀ࣔࢹࣝ⣔ࡀุ᫂ࡋࡓࠋEV71ࡢಶయ㛫ఏ᧛࡟క࠸ࢃࡎ࠿࡞ኚ␗ࢆ⵳ ᑠụ ᬛ࡞࡝ࢆ☜❧ࡋ᭷ຠ࡞࣡ࢡࢳࣥࢆ㛤Ⓨࡍࡿࡇ࡜ࢆ┠ᶆ࡜ࡍ✚ࡋࠊ⑓ཎᛶࡢ␗࡞ࡿ᪂ࡓ࡞ᰴ⩌ࡀᖖ࡟⏕ᡂࡉࢀ࡚࠸ࡿࡇ ᑠᯘ㒓௓ࡿࠋ࡜ࢆド᫂ࡋࡓࠋᲚཎ┤ᶞ࣭ ࡉࡽ࡟ୖグࡢEV71ᙉẘᰴ࡜ᙅẘᰴࡢ࣓࢟ࣛ࢘࢖ࣝࢫࢆస
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼〇ࡋ࡚ẘຊ࡟ᙳ㡪ࢆ୚࠼ࡿ㒊఩ࡀ5 -UTR࡟࠶ࡿࡇ࡜ࢆྠ
࣭ Miwatashi , Ishida M, Takashino A, Kobayashi K,
Yamaguchi M, Shitara H, Koike S. Mouse Scarb2
ᐃࡋࠊࡑࡢ୰࡛ࡶ≉࡟2ሷᇶࡢኚ␗ࡀ㔜せ࡛࠶ࡿࡇ࡜ࢆ✺Modulates EV71 Pathogenicity in Neonatal Mice. J.
ࡁṆࡵࡓࠋ
Virol. 96(15) e0056122. doi: 10.1128/jvi.00561-22.
࣭ ࡉࡽ࡟㏆ᖺ㔜⑕౛ࢆక࠺኱つᶍ࡞EV71ࡢὶ⾜ࡀ࠶ࡗࡓ࣋
PMID: 35867561 㸦ᰝㄞ᭷㸧ࢺࢼ࣒ࠊ୰ᅜ࡞࡝ࡢᰴࢆㄪ࡭ࡓ࡜ࡇࢁࠊୖグᙉẘᆺᰴࡀὶ࣭ Tamura K, Kohnoe M, Takashino A, Kobayashi K,⾜ࡋ࡚࠸ࡓࡇ࡜ࢆぢฟࡋࡓࠋࡍ࡞ࢃࡕࠊ5 UTRࡣࡇࡢ࢘࢖
Koike S, Karwal L, Fukuda S, Vang F, Das SC, DeanࣝࢫࡢẘຊࢆỴᐃࡍࡿ᭱ࡶ㔜せ࡞㒊఩࡛࠶ࡾࠊࡇࡢ㒊఩ࡢ
HJ. TAK - 021, an inactivated Enterovirus 71 vaccineኚ␗࡜㔜⑕໬࡟ࡣ῝࠸㛵㐃ࡀ࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋ
candidate,providescross-protection
against࣭ୖグᙉẘኚ␗௨እ࡟࢘࢖ࣝࢫࡢẘຊ࡜㛵ࢃࡾࡢ࠶ࡿ⟠ᡤࢆ
heterologous sub-genogroups in human scavenger᥈ࡋࡓ࡜ࡇࢁࠊ࢘࢖ࣝࢫࡢ࢝ࣉࢩࢻ㡿ᇦࡶᙉẘ໬࡜㛵㐃ࡀ
receptor B2 transgenic mice. Vaccine 40(24):3330࠶ࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
3337. doi: 10.1016/j.vaccine.2022.04.064. PMID:
35501179㸦ᰝㄞ᭷㸧(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼
࣭ 5 UTR࡟ྠᐃࡉࢀࡓᙉẘ࣭ᙅẘᛶࢆኚ໬ࡉࡏࡿኚ␗ࡀ࡝
(3) ᅜෆእࡢ◊✲≧ἣࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡟ᇶ࡙࠸࡚ኚ໬ࡍࡿ࠿ࠊࡑࡢ࣓࢝ࢽ
EV71ࣞࢭࣉࢱ࣮㑇ఏᏊ༢㞳ࡣୡ⏺࡛ᡃࠎࡀࡣࡌࡵ࡟ᡂ
ࢬ࣒ࢆ᥈⣴ࡍࡿࠋ
ຌࡋࡓࠋ௒ᖺᗘࡣື≀ࣔࢹࣝࢆ⏝࠸ࡓ࢘࢖ࣝࢫࡢẘຊࡢ ࣭ ࢝ࣉࢩࢻ㡿ᇦࡢኚ␗࡟ࡼࡿᙉẘ໬ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍホ౯࡟㛵ࡍࡿ◊✲ࡀ㐍ᒎࡋࡓࠋᅜෆእ࡛ࡇࡢࡼ࠺࡞ᐇ㦂ࡿࠋ⣔ࢆᣢࡗ࡚࠸ࡿࢢ࣮ࣝࣉࡣ࡞࠸ࠋEV71࣡ࢡࢳࣥࡢ㛤Ⓨࡣ ࣭ ࡇࢀࡲ࡛⾜ࡗ࡚࠸ࡓ࣡ࢡࢳࣥ㛤Ⓨࡣ◊✲௦⾲⪅ࡀ୰Ṇࢆ୰ᅜ࡛ᐇ⏝໬ࡉࢀࡓࡀࠊ⏕⏘㔞࡞࡝ࡢၥ㢟ࡀ࠶ࡿࡓࡵࠊ
Ỵᐃࡋࡓࡓࡵ⤊஢ࡋࡓࡀࠊูࡢ᪂ࡓ࡞ᯟ⤌ࡳ࡛࣡ࢡࢳࣥ
௒ᚋࡉࡽ࡞ࡿᨵⰋࡀ࡞ࡉࢀࡓ࣡ࢡࢳࣥࡀᚲせ࡜ࡉࢀ࡚࠸
㛤Ⓨࢆ┠ᣦࡍࠋ
ࡿࠋࡇࡢ࢘࢖ࣝࢫࡢ⑓ཎᛶࢆỴᐃࡋ࡚࠸ࡿኚ␗ࡢ◊✲࡟࠾࠸࡚ࡶୡ⏺ࢆ࣮ࣜࢻࡋ࡚࠸ࡿࠋ

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ᡂᯝࡢᴫせ
 㑇ఏᏊ἞⒪࡟ࡼࡿど⚄⤒෌⏕㸦Molecular Therapy㸧⚄⤒ᰤ㣴ᅉᏊཷᐜయ࡛࠶ࡿ 7UN% ࡢ⣽⬊ෆ㡿ᇦࢆษࡾฟࡋࠊேᕤⓗ࡟⣽⬊⭷࡟⤖ྜࡉࡏࡿࡇ࡜࡟ࡼࡗ࡚ࠊᖖ࡟άᛶᆺ࡜࡞ࡿ 7UN% ศᏊࢆ㛤ⓎࡋࡓࠋྠศᏊࢆ⤌ࡳ㎸ࢇࡔ㑇ఏᏊ἞⒪࣋ࢡࢱ࣮ࢆ║⌫ෆ࡟ᢞ୚ࡍࡿ࡜ࠊ⥳ෆ㞀ࣔࢹࣝ࡟࠾࠸࡚㐍⾜ࡀᢚไࡉࢀࡓࠋど⚄⤒ᦆയࣔࢹࣝ࡟࠾࠸࡚ࡣࠊከࡃࡢ෌⏕⥺⥔ࡀど஺ཫࡲ࡛฿㐩ࡋࡓࠋࡉࡽ࡟どぬ㔝௜㏆࡛どぬ㊰ࢆษ᩿ࡋࡓ࣐࢘ࢫ࡛ࡣࠊ㍈⣴ࡢ෌⏕࡜ඹ࡟ࠊどᶵ⬟ࡀ㒊ศⓗ࡟ᅇ᚟ࡋࡓࠋ௨ୖ࠿ࡽᨵኚᆺ 7UN% ࢆ⏝࠸ࡓ㑇ఏᏊ἞⒪ࡀࠊ⥳ෆ㞀ࡢ㐍⾜ᢚไࡸどᶵ⬟ᅇ᚟࡟ᐤ୚ࡍࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋㄽᩥᥖ㍕ㄅ䞉Ⓨ⾲Ꮫ఍ྡ➼࣭ 1LVKLMLPD(+RQGD6.LWDPXUD<HWDOMolecular Therapy
࣭ .L\RWD1HWDONeuroscience Letters
࣭ ,QRXH<DQDJLPDFKL0HWDOExp Eye Res
࣭ *XR;.LPXUD$1DPHNDWD.HWDOPNAS,
࣭ 6KLQR]DNL<HWDOScience Advances
࣭ 1DPHNDWD.HWDOJournal of Biological Chemistry
࣭ +DUDGD&HWDOAntioxidants࣭ ཎ⏣㧗ᖾ ➨  ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘࣭ .L\RWD1HWDO$592PHHWLQJ࣭ ཎ⏣㧗ᖾ ➨  ᅇ᪥ᮏ⚄⤒║⛉Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘
࣭ .LPXUD$HWDO1HXURVFLHQFH0HHWLQJ࣭ ⾜᪉࿴ᙪ ➨  ᅇ᪥ᮏ⏕໬Ꮫ఍࣭ ཎ⏣㧗ᖾ ➨  ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘
࣭ 1LVKLMLPD(HWDO:RUOG*ODXFRPD&RQJUHVV
࣭ *XR;HWDO$592PHHWLQJ

㑇ఏᏊ἞⒪࡟ࡼࡿど⚄⤒෌⏕㸦Science Advances㸧⥳ෆ㞀ࣜࢫࢡ㑇ఏᏊࡢ㸯ࡘ࡛࠶ࡿ $%&$ ࡣ࢔ࢫࢺࣟࢧ࢖ࢺ࡟㧗Ⓨ⌧ࡍࡿࡇ࡜ࢆⓎぢࡋࡓࠋ࢔ࢫࢺࣟࢧ࢖ࢺ≉␗ⓗ $%&$ Ḟᦆ࣐࢘ࢫࢆస〇ࡍࡿ࡜ࠊṇᖖ║ᅽ⥳ෆ㞀ࡢ⑕≧ࢆ࿊ࡋࡓࠋ㸯⣽⬊ 51$ ࢩ࣮ࢡ࢚ࣥࢫࡢ⤖ᯝ࠿ࡽࠊ$%&$ ࡀḞᦆࡋࡓ࢔ࢫࢺࣟࢧ࢖ࢺ࡛ࡣࡼ
ࡾከࡃࡢࢣࣔ࢝࢖ࣥࢆ⏘⏕ࡍࡿࡇ࡜࡟ࡼࡗ࡚ࠊ⅖⑕ࢆច㉳ࡍࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ௨ୖ࠿ࡽࠊ࢔ࢫࢺࣟࢧ࢖ࢺࡀ⥳ෆ㞀➼࡟࠾ࡅࡿ᪂ࡓ࡞
἞⒪ᶆⓗ࡜࡞ࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋᅜෆእ䛾◊✲≧ἣ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣐࢘ࢫ࠾ࡼࡧ࣐࣮ࣔࢭࢵࢺ㸦㟋㛗㢮㸧࡟࠾ࡅࡿṇᖖ║ᅽ⥳ෆᙜࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊᨵኚᆺ⚄⤒ᰤ㣴ᅉᏊཷᐜయࢆ⏝࠸ࡓ᪂ࡓ࡞
㞀ࣔࢹࣝࡢ☜❧ࡣᙜࣉࣟࢪ࢙ࢡࢺ࡟ࡼࡿୡ⏺ึࡢᡂᯝ࡛࠶ࡿࠋ 㑇ఏᏊ἞⒪࣋ࢡࢱ࣮ࢆ㛤Ⓨࡋࠊ≉チ⏦ㄳࢆ⤊࠼࡚࠸ࡿࠋྠ࣋ࢡࢱ࣮
㑇ఏᏊ἞⒪ࡸᖿ⣽⬊⛣᳜➼࡟ࡼࡗ࡚⥳ෆ㞀ࡢண㜵ࡸど⚄⤒෌ ࡛ࡣᙉຊ࡞⚄⤒ಖㆤຠᯝ࡜ど⚄⤒෌⏕ຠᯝࢆᚓࡽࢀࡿࡇ࡜࠿ࡽࠊ⮫⏕ࢆㄏᑟࡍࡿ᪉ἲࡣࠊୡ⏺ⓗ࡟ࡶ඲ࡃ▱ࡽࢀ࡚࠸࡞࠸ࠋ
ᗋᛂ⏝࡟ྥࡅࡓ᳨ウࢆ㐍ࡵࡿィ⏬࡛࠶ࡿࠋ

ど⚄⤒⅖࡟࠾ࡅࡿ PLFURJOLD ࡢᶵ⬟ゎ᫂㸦PNAS㸧
0$3. ࡢ㸯ࡘ࡛࠶ࡿ $6. ࡣከⓎᛶ◳໬⑕ࣔࢹࣝࡢ㔜⑕໬࡟㛵୚ࡍࡿࠋ᪂つ࡟⣽⬊✀≉␗ⓗ $6. Ḟᦆ࣐࢘ࢫࢆస〇ࡋࡓ⤖ᯝࠊ
PLFURJOLD ࡟Ⓨ⌧ࡍࡿ $6. ࡣⓎ⑕᪩ᮇ࡟ࠊDVWURF\WH ࡢ $6. ࡣᚋᮇ࡟ࠊ௚᪉ࡢ⣽⬊✀࡟ാࡁ࠿ࡅ࡚⅖⑕ࢆቑᝏࡉࡏ࡚࠸ࡓ ࡘࡲࡾ $6.
ࡣ PLFURJOLDíDVWURF\WH 㛫ࡢ┦஫స⏝ࢆ⑓ᮇ≉␗ⓗ࡟ไᚚࡍࡿࡓࡵࠊ᭷
⏝࡞἞⒪ᶆⓗ࡜࡞ࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋᴫせ᪥ᮏ࡟࠾ࡅࡿ୰㏵ኻ᫂ཎᅉࡢከࡃࡣ⥙⭷࠾ࡼࡧど⚄⤒ࡢኚᛶ⑌ᝈ࡛࠶ࡿࠋࡲࡓ㏆ᖺ࡛ࡣࠊ㧗㱋໬♫఍ࢆ⫼ᬒ࡟ࠕ║ࡢᡂே⑓ࠖ࡜ࡶ࠸࠼ࡿ⥳ෆ㞀࡞࡝ࡢᝈ⪅ᩘቑຍࡀ኱ࡁ࡞ㄢ㢟࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ㧗㱋໬ࢆ㏄࠼ࡿ᪥ᮏ♫఍඲యࡢ 42/ྥୖ࡜ࠊ㒔Ẹࡢࢽ࣮ࢬ࡟ᗈࡃᛂ࠼ࡿࡓࡵ࡟ࠊ㞴἞ᛶ║⑌ᝈࣔࢹࣝࡢ㛤Ⓨࢆ㏻ࡋ࡚ࠊࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒࡜἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ≉࡟㑇ఏᏊ἞⒪࡞࡝ࡢᡭἲ࡟ࡼࡗ࡚ࠊ⥙⭷࣭ど⚄⤒ࡢಖㆤࡸ෌⏕ࢆಁ㐍ࡋࠊ⥳ෆ㞀➼ࡢ㐍⾜ᢚไ࡟ຍ࠼࡚ࠊ୍᪦ኻࢃࢀࡓどᶵ⬟ࢆಶయ࡛ࣞ࣋ࣝᅇ᚟ࡉࡏࡿࡇ࡜ࢆ┠ᶆ࡜ࡍࡿࠋ



ᐈဨ◊✲ဨ
኱ᶫ ຮ

㔝࿅㝯ᙪ
すᓥ⩏㐨
እᅬᬗᏊ
㸦ᮾிឿᜨ఍་⛉኱Ꮫ║⛉㸧ᮏ⏣⣪㔛㸦㡰ኳᇽ኱Ꮫ║⛉㸧໭ᮧ⿱ኴ㸦༓ⴥ኱Ꮫ║⛉㸧Ύ⏣┤ᶞ㸦ᮾ໭኱Ꮫ║⛉㸧ࢭࢢࣛ࢝࢜ࣜ
㸦ᮾ㑥኱Ꮫ⌮Ꮫ㒊㸧
ཎ⏣▱ຍᏊ


◊✲⪅ྡ
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⾜᪉࿴ᙪ
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
◊✲ᮇ㛫
ᖺ᭶㹼ᖺ᭶㸦 ᖺ㛫㸧

㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌◊✲ᮇ㛫䞉◊✲⪅ྡ➼㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ཎ⏣㧗ᖾ㸧㸦◊✲௦⾲⪅ྡ㸧㻌◊㻌 㻌 㻌 㻌 㻌 㻌 㻌✲㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᡂ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᯝ㻌㻌⥙⭷࣭ど⚄⤒ࡢಖㆤ࡜෌⏕࡟ࡼࡿどぬ㞀ᐖࡢ἞⒪ἲࡢ㛤Ⓨ㸭どぬ⑓ែࣉࣟࢪ࢙ࢡࢺ

◊✲ㄢ㢟ྡ㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊㻌 㻌 ✲㻌 㻌 ෆ㻌 㻌 ᐜ୺࡞◊✲ᡂᯝ

－－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ⢾ᒀ⑓࡟క࠺ᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢᇶ♏◊✲࡟ᚑ஦ࡍࡿ
◊✲⪅࣭་ᖌࡀᑡ࡞࠸≧ἣࡢ୰࡛ࠊᙜࣉࣟࢪ࢙ࢡࢺࡣ୺せ◊✲ᣐⅬࡢ୍ࡘ࡜ࡋ࡚ᮇᚅࡉࢀ࡚࠸ࡿࠋᘯ๓኱ࠊឡ▱Ꮫ㝔኱ࠊឿᜨ་኱ࠊᕝᓮ་኱ࠊᮾி⸆⛉኱ࠊᮥᯘ኱㸦ᮎᲈ⚄⤒㞀ᐖ㸧ࠊ㜰኱ࠊⰪᾆᕤ኱㸦ㄆ▱⑕㸧➼࡜ࡢඹྠ◊✲ࢆ᥎㐍ࡋࠊࡑࡢᡂᯝࢆ㒔ᨻ࡟㑏ඖࡍࡿ࡜࡜ࡶ࡟ᅜෆእ࡟ྥࡅ࡚ᗈࡃⓎಙࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ JCI Insight (2022)
࣭ Kidney International (2022)
࣭ International Journal of Molecular Sciences (2022, 2021)
࣭ Scientific Reports (2021)
࣭ Journal of Neurochemistry (2021)
࣭ Brain Communications (2020)
࣭ Histochemistry and Cell Biology (2020)࣭ ᭶ห⢾ᒀ⑓ (2020)࣭ ᪥ᮏ⢾ᒀ⑓Ꮫ఍ࠊ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ࠊ⢾ᒀ⑓Ꮫࡢ㐍Ṍࠊ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍ࠊ᪥ᮏ⚄⤒Ꮫ఍ࠊ᪥ᮏᮎᲈ⚄⤒Ꮫ఍࣭ ᪥ᮏ⏕⌮Ꮫ఍ࠊ᪥ᮏ⏕໬Ꮫ఍ࠊ᪥ᮏศᏊ⏕≀Ꮫ఍(1)

ᴫせ࣭ ゎ⢾⣔ഃ๪㊰௦ㅰஹ㐍ࠊ⢾໬ࠊ㓟໬ࢫࢺࣞࢫࠊ Rho/Rho
kinaseஹ㐍➼ࢆ௓ࡋࡓ⢾ᒀ⑓ᛶᮎᲈ⚄⤒㞀ᐖࡢⓎ⑕ᶵᵓゎ᫂ࠊ᭷ຠ࡞἞⒪ἲࡢ☜❧࣭ */3íཷᐜయసື⸆exendin-4ࡸࠊ࡚ࢇ࠿ࢇ࣭ࣃ࣮࢟ࣥࢯ
ࣥ⑓἞⒪⸆zonisamideࡢᮎᲈ⚄⤒ಖㆤస⏝ࡢᶵᵓゎ࣭᫂ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓࠊ㐣ᰤ㣴ࡸ⢾ᒀ⑓࡟ࡼࡿ⚄⤒ኚᛶᶵᵓゎ࣭᫂ 㛵㐃ࡍࡿᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢ⑓ែゎ᫂୺࡞◊✲ᡂᯝ✲       ᡂ
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(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⢾ᒀ⑓ᛶᮎᲈ⚄⤒㞀ᐖࡢ⣽⬊࣭ಶయ࡛ࣞ࣋ࣝࡢゎᯒࢆ㐍ࡵࠊᡂᅉ࡟ᇶ࡙ࡃ἞⒪⸆ࡢ㛤Ⓨ࡟㈉⊩ࡍࡿࠋ㔝⏕ᆺࢩࣙ࢘ࢪࣙ࢘ࣂ
࢚ࢆ㧗⢾㉁㣗࡛㣫⫱ࡋࠊᮎᲈ⚄⤒ࡢኚᛶࡸࢱࣥࣃࢡ㉁จ㞟࡬ࡢᙳ㡪ࢆ᳨ウࡍࡿࠋࡲࡓ௚᪋タ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ㑇ఏᛶࠊ⸆๣ᛶࠊච␿௓ᅾᛶᮎᲈ⚄⤒㞀ᐖࡢ⑓ែゎ᫂࡟㈉⊩ࡍࡿࠋᡂᯝࡢᴫせ࣭ ⢾ᒀ⑓࣐࢘ࢫయෆ࡛ቑຍࡋࡓ᭱⤊⢾໬⏘≀AGEsࡀ࣐ࢡࣟࣇ࢓
࣮ࢪࡢཷᐜయRAGE࡟⤖ྜࡋ࡚⅖⑕ㄏᑟᛶᙧ㉁M1࡜࡞ࡾࠊᮎ
ᲈ⚄⤒ࡢ࢖ࣥࢫࣜࣥࢩࢢࢼࣝࡸ㏫⾜ᛶ㍈⣴㍺㏦ࢆ㞀ᐖࡋ⣽⬊యࡢኚᛶࢆㄏᑟࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (JCI Insight 2022)ࠋ
࣭ zonisamideࡣp38 MAP kinaseࢩࢢࢼࣝࡢᢚไ࠾ࡼࡧPI3 kinaseࢩࢢࢼࣝࡢஹ㐍ࢆ௓ࡋ࡚ࠊᢠࡀࢇ๣oxaliplatin࡟ࡼࡿDRGࢽ࣮ࣗࣟࣥࡢ⣽⬊ṚࡸDRGࢽ࣮ࣗࣟࣥࢩࣗ࣡ࣥ⣽⬊ඹᇵ㣴⣔ࡢ㍈⣴ኚᛶ࣭⬺㧊ᵝ⑓ኚㄏᑟࢆ⦆࿴ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (IntJ Mol Sci 2022)ࠋ
࣭ ᚋ᰿⚄⤒⠇ (DRG)ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊ࢆ㧗ࢢࣝࢥ࣮ࢫ
࣭እᅉᛶࣆࣝࣅࣥ㓟Ḟኻ⎔ቃୗ࡟ᭀ㟢ࡍࡿ࡜ࠊゎ⢾⣔㸫TCA
ᅇ㊰ࢆ௓ࡋࡓATP⏘⏕ࡀⴭࡋࡃ㜼ᐖࡉࢀࠊゎ⢾⣔ഃ๪㊰௦ㅰࡸ㓟໬ࢫࢺࣞࢫࡀஹ㐍ࡋࠊ▷᫬㛫࡛㢧ⴭ࡞⣽⬊Ṛࡀㄏᑟࡉࢀ
ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸦Sci Rep 2021㸧ࠋ࣭ exendin-4ࡣࡑࡢ⮅స⏝㸦࢖ࣥࢫࣜࣥศἪಁ㐍㸧࡟ຍ࠼ࠊDRG
ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊࡟┤᥋స⏝ࡋࠊPI3 kinase⤒㊰ࢆ௓ࡋ࡚⚄⤒✺㉳ఙ㛗ࠊࢩࣗ࣡ࣥ⣽⬊㐟㉮ࠊ㧊㠧ᙧᡂࢆಁ㐍ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (Int J Mol Sci 2021)ࠋ
࣭ ࢺࣛࣥࢫࢧ࢖ࣞࢳࣥE61Kኚ␗࡟ࡼࡿ࢔࣑ࣟ࢖ࢻࢽ࣮ࣗࣟࣃࢳ
࣮ࡢ⑓ែ࡟ࠊࢩࣗ࣡ࣥ⣽⬊ࡢ࢔࣏ࢺ࣮ࢩࢫࡀ㛵୚ࡍࡿࡇ࡜ࢆ
᫂ࡽ࠿࡟ࡋࡓ (J Neurochem 2021)ࠋ
࣭ 㧗⾑⢾ୗ࡛ࢢࣝࢥࢧ࣑ࣥࡀᮎᲈ⚄⤒࡟⵳✚ࡋࠊ࢖ࣥࢫࣜࣥࢩ
ࢢࢼࣝࡢᢚไࡸATP⏘⏕ࡢ㜼ᐖࢆ௓ࡋ࡚ᮎᲈ⚄⤒㞀ᐖࡢⓎ⑕࡟㛵୚ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (Brain Commun 2020)ࠋ
(1)

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(2) ◊✲⪅ྡ୕஬୍᠇㸦་Ꮫ◊㸧㕥ᮌ࣐ࣜ㸦་Ꮫ◊㸧ඵᏊⱥྖ㸦་Ꮫ◊㸧ຍ⸨ᏹ୍㸦ឡ▱Ꮫ㝔኱㸧ᮧୖ㱟ᩥ㸦ᕝᓮ་኱㸧ᒣෆ῟ྖ㸦ᮾி⸆⛉኱㸧ᮧᯇ᠇㸦ᮥᯘ኱㸧(1)◊✲ᮇ㛫2020ᖺ4᭶㹼2025ᖺ3᭶
㸦5ᖺ㛫㸧

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୕஬୍᠇㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ－－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᅜෆእࡢ◊✲≧ἣᅜෆእ࡛ࠊiPS⣽⬊࡜ࢤࣀ࣒⦅㞟ࢆ⤌ࡳྜࢃࡏࡓ◊✲ࡣ┒ࢇ࡟㐍ࡵࡽࢀ࡚࠾ࡾࠊᇶ♏◊✲ࡸᢏ⾡㛤Ⓨ࡟ຍ࠼ࠊ⮫ᗋᛂ⏝࡟ྥࡅࡓྲྀ⤌ࡳࡶ㐍ࢇ࡛࠸ࡿࠋ

(3)㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ✲       ᡂ
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(1) ᡂᯝࡢᴫせ࣭ ࢤࣀ࣒⦅㞟⤖ᯝࢆEGFP࡜mCherryࡢ⺯ග࡟ࡼࡗ᳨࡚ฟ࡛ࡁࡿ࣏࣮ࣞ
ࢱ࣮K562⣽⬊ࢆ⏝࠸࡚ࠊ⤌᥮࠼ࡀ㉳ࡁࡓ⣽⬊࡟≉␗ⓗ࡟Ⓨ⌧ࡋ࡚࠸ࡿ㑇ఏᏊ⩌ࢆRNAseq࡟ࡼࡾྠᐃࡋࡓࠋUV↷ᑕ࡟཯ᛂࡋ࡚⣽⬊࡛Ⓨ⌧ࡀୖ᪼ࡍࡿ㑇ఏᏊ࡞࡝ࡀከࡃྵࡲࢀ࡚࠾ࡾࠊDNA⤌᥮࠼࡟㛵୚ࡍࡿ㑇ఏᏊࡀᮇᚅ㏻ࡾ࡟ྠᐃࡉࢀ࡚࠸ࡿࡇ࡜ࡀ☜ㄆ࡛ࡁࡓࠋྠᐃࡋࡓ
㑇ఏᏊࡢ୍㒊࡟ࠊᤄධ࣭Ḟኻࡢㄏᑟࢆᢚไࡍࡿάᛶࡶㄆࡵࡽࢀࡓࠋ
࣭ Single Particle isolation System (SPiS)࡜࠸࠺⮬ື㸯⣽⬊ศὀ⿦⨨ࢆ⏝࠸࡚ࠊࢤࣀ࣒⦅㞟ࢆ⾜ࡗࡓࣄࢺᇵ㣴⣽⬊ࡢ㸯⣽⬊⏤᮶ࢡ࣮ࣟࣥࢆከᩘ
༢㞳ࡋࠊḟୡ௦ࢩ࣮ࢡ࢚ࣥࢫ࡟ࡼࡾゎᯒࡋࡓࠋࡑࡢ⤖ᯝࠊ㸯⣽⬊༢఩࡛ほᐹࡍࡿ࡜ࠊ඲࡚ࡢᶆⓗ㑇ఏᏊࡀ⦅㞟ࡉࢀࡿ⣽⬊࡜ࠊ඲ࡃࢤࣀ
࣒⦅㞟ࡀ㉳ࡇࡽ࡞࠸⣽⬊࡟஧ᴟ໬ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋྠᵝࡢഴྥࡀゎᯒࢆ⾜ࡗࡓHEK293T⣽⬊ࠊHeLa⣽⬊ࠊPC9⣽⬊ࡢ඲࡚࡛ほᐹࡉࢀࡓࡓࡵࠊࢤࣀ࣒⦅㞟ࡢ୍⯡ⓗ࡞≉ᛶ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋ࣭ ⌮◊ࡢᯘὒᖹ༤ኈ࡜ࡢඹྠ◊✲࡛ࠊࢤࣀ࣒⦅㞟ࢆ⾜ࡗࡓࣄࢺiPS⣽⬊࠿ࡽศ໬ࡉࡏࡓ⫢⣽⬊ࡢ࢘࢕ࣝࢯࣥ⑓ࣔࢹࣝゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ࢘࢕ࣝࢯࣥ⑓ࡢཎᅉ࡛࠶ࡿATP7B㑇ఏᏊࡢኚ␗࡟ࡣᵝࠎ࡞✀㢮ࡀ࠶ࡿࡀࠊ୍㒊ࡢኚ␗ࡣATP7Bࡢࢱࣥࣃࢡ㉁㔞ࢆῶᑡࡉࡏࡓ୍᪉ࠊ
ATP7B㔞ࡀኚኚ໬ࡋ࡞࠸ኚ␗ࡶㄆࡵࡽࢀࡓࠋᙜࣉࣟࢪ࢙ࢡࢺ࡛ゎᯒࢆ㐍ࡵ࡚ࡁࡓR778Lኚ␗ࡣࠊATP7Bࡢࢱࣥࣃࢡ㉁㔞ࢆῶᑡࡉࡏࡿኚ␗
࡛࠶ࡗࡓࠋ୍᪉࡛ࠊATP7Bࡢ඲࡚ࡢኚ␗࡟ࡼࡗ࡚ࠊCeruloplasminࡢศἪ㔞ࡣపୗࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ࣭ ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢ᭱኱ࡢ༴㝤ᅉᏊ࡛࠶ࡿAPOEከᆺࢆᣢࡘiPS⣽⬊ࡢస〇ࢆࢤࣀ࣒⦅㞟࡟ࡼࡾ㐍ࡵࡓࠋ◊⬊࡟࠾࠸࡚ホ౯ࡍࡿࠋᰁⰍయᩘࢆ⥔ᣢࡋࡓ⣽⬊✀࡟ࡶ㐺⏝ࡍࡿࡓࡵ࡟ࠊ㧗ຠ⋡࡞ࢡ࣮ࣟࣥ
༢㞳ࢆྍ⬟࡟ࡍࡿࢤࣝᇵ㣴ἲࢆ㛤Ⓨࡍࡿࠋ࣭ APOEከᆺࢆࢤࣀ࣒⦅㞟ࡋࡓiPS⣽⬊⏤᮶⚄⤒⣔⣽⬊ࢆ⏝࠸ࡓࠊ࢔ࣝ
ࢶࣁ࢖࣐࣮⑓ࣔࢹࣝࢆ☜❧ࡍࡿࠋ࣭ 㸯⣽⬊ࡈ࡜ࡢࢤࣀ࣒⦅㞟⤖ᯝゎᯒᡭἲࢆࠊࣄࢺiPS⣽⬊࡞࡝ࡢṇᖖ࡞

◊✲⪅ྡ
భ୍㑻
᭸Ꮚ
๛
ඹྠ◊✲⪅
Bruce Conklin(Gladstone Institutes, USA)
Nathan Salomonis(Cincinnati Children s
Hospital, USA)
Chuck Murry(University of ashington)ᯘ ὒᖹ㸦⌮◊ࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥ
ࢱ࣮㸧

ᐑᒸ
ຍ⸨
㧗ᶫ

(2)

(1)

◊✲ᮇ㛫
2020ᖺ4᭶㹼2025ᖺ3᭶
㸦5ᖺ㛫㸧

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iPS⣽⬊ᢏ⾡࡜ࢤࣀ࣒⦅㞟ᢏ⾡ࡢ⼥ྜ࡟ࡼࡿ㑇ఏᛶ⑌ᝈࡢ἞⒪ἲࡢ㛤Ⓨ㸭෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᐑᒸభ୍㑻㸧ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
ཎⴭㄽᩥ
ྠ➼㈉⊩
࣭ de Majo M , Koontz M , et al. Granulin loss of function in humanmature brain organoids implicates astrocytes in TDP-43 pathology.
Stem Cell Reports S2213-6711 2023
࣭ Takahashi G, et al. Genome editing is induced in a binary mannerin single human cells. iScience 25:105619. 2022
࣭ Song D , Takahashi G , et al. Retinoids rescue ceruloplasminsecretion and alleviate oxidative stress in ilson s disease-specifichepatocytes. Human Molecular Genetics 31:3652-3671. 2022
࣭Ⓨ⾲Ꮫ఍(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Cold Spring Harbor Laboratory Meeting, Genome Engineering࣭ ⺯ග࣏࣮ࣞࢱ࣮K562⣽⬊ࢆ⏝࠸࡚ྠᐃࡋࡓࠊ⤌᥮࠼࡟ࡼࡿࢤࣀ࣒⦅
࣭ ➨45ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍㞟ࢆಁ㐍ࡍࡿࡇ࡜ࡀண ࡉࢀࡿศᏊࡢάᛶࢆࠊHEK293T⣽⬊ࡸiPS⣽࣭ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍➨7఍኱఍

(2)

(1)

ᴫせ
iPS⣽⬊࡟ࡣᵝࠎ࡞་⒪ᛂ⏝ࡀᮇᚅࡉࢀࠊ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋࡉࡽ࡟ࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓎᒎ࡟ࡼࡾࠊiPS⣽⬊ࡢ㑇ఏ᝟ሗᨵኚࡀྍ⬟࡜࡞ࡾࡘࡘ࠶ࡾࠊᛂ⏝ࡢྍ⬟ᛶࡣ኱ࡁࡃᗈࡀࡗ࡚࠸ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊiPS⣽⬊ࡢࢤࣀ࣒⦅㞟ࢆࠊ἞⒪ຠᯝࢆ㧗ࡵࡓ⣽⬊ࢆ⏝࠸ࡓ⛣᳜἞⒪ࠊ㑇ఏⓗ⫼ᬒࡀྠ୍࡞⑌ᝈ
ࣔࢹࣝ࡞࡝ࠊᖜᗈ࠸iPS⣽⬊ࡢ་⒪ᛂ⏝࡟ࡘ࡞ࡆࡿࠋ㏫࡟ࠊ
ࣄࢺࡢࢤࣀ࣒DNAࢆ᭷ࡋࠊ࠶ࡽࡺࡿ⣽⬊✀࡟ศ໬࡛ࡁࡿiPS⣽⬊ࢆホ౯⣔࡜ࡋ࡚ࠊ་⒪࡬ᛂ⏝ྍ⬟࡞ࠊṇ☜࡛㧗ຠ⋡࡞ࢤࣀ࣒⦅㞟ᢏ⾡ࡢ㛤Ⓨࢆ⾜࠺ࠋࡇࢀࡽࡢ◊✲ࢆ㏻ࡋ࡚ࠊ㑇ఏᛶ⑌ᝈࡢ᪂ࡓ࡞἞⒪ἲࡢ㛤Ⓨࢆ┠ⓗ࡜ࡍࡿࠋ୺࡞◊✲ᡂᯝ

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ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼㸦ᖺᗘ㸧.XUDRNDHWDOP%LRH
72%,5$➨ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ୹㔝⚽ᓫ㸦ᣍᚅㅮ₇㸧➨ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍ ୹㔝⚽ᓫ ࣏ࢫࢱ࣮Ⓨ⾲⣽⬊ࢆ๰ࡿ◊✲఍ ୹㔝⚽ᓫ ࣏ࢫࢱ࣮Ⓨ⾲

(3)ᅜෆእࡢ◊✲≧ἣࡀࢇ≉␗ⓗ7&5ࢆ⏝࠸ࡓ⮫ᗋヨ㦂ࡣ௳ࡀୡ⏺୰࡛ᐇ᪋ࡉ
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ࢆⓎ⌧ࡋ࡚࠸࡞࠸ࡓࡵᮏ㑇ఏᏊ἞⒪ἲࢆཷࡅࡿࡇ࡜ࡀ࡛ࡁ࡞
࠸ࠋ࡝ࡢࡼ࠺࡞S+/$ࢆⓎ⌧ࡋ࡚࠸࡚ࡶࡑࢀ࡟⤖ྜࡍࡿ7&5ࢆ
㎿㏿࡟Ⓨぢ࡛ࡁࢀࡤࠊ7&5㑇ఏᏊ἞⒪ἲࡢ୍⯡໬࡟኱ࡁࡃ㏆
௜ࡃࡀࠊ7&5S+/$ࡢ┦஫స⏝ࢆ⥙⨶ⓗ࡟ゎᯒ࡛ࡁࡿᢏ⾡ࡣ⌧ᅾࡢ࡜ࡇࢁᏑᅾࡋ࡞࠸ࠋ

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(2)

(1)

ᴫせ
7⣽⬊ࡣ⣽⬊⾲㠃࡟Ⓨ⌧ࡍࡿ7FHOOUHFHSWRU 7&5 ࢆ௓ࡋࠊ⑓ཎ⣽⬊ࡀⓎ⌧ࡍࡿSHSWLGH+/$ S+/$ 」ྜయࢆㄆ㆑ࡋࠊ⑓
ཎ⣽⬊ࢆẅയࡍࡿࠋ㏆ᖺࠊࡀࢇ≉␗ⓗ7&5ࢆࡀࢇᝈ⪅ࡢ7⣽⬊
࡟Ⓨ⌧ࡉࡏࡿ㑇ఏᏊ἞⒪ἲࡀ┠ぬࡲࡋ࠸ᡂᯝࢆᣲࡆ࡚࠸ࡿࠋ
ࡋ࠿ࡋࠊ᪤Ꮡࡢᢏ⾡࡛ࡣࡀࢇ≉␗ⓗ7&5ࢆⓎぢࡍࡿࡇ࡜ࡀᅔ
㞴࡛࠶ࡗࡓࡾࠊ+/$ᣊ᮰ᛶࡢၥ㢟࠿ࡽⓎぢࡉࢀࡓࡀࢇ≉␗ⓗ7&5ࡣᴟ୍㒊ࡢᝈ⪅࡟ࡋ࠿㐺⏝࡛ࡁ࡞࠸࡜࠸ࡗࡓၥ㢟ࡀᏑᅾ
ࡋࠊᮏ἞⒪ἲࢆ୍⯡໬ࡍࡿࡇ࡜ࡀᅔ㞴࡛࠶ࡿࠋࡑࡇ࡛ᮏࣉࣟ
ࢪ࢙ࢡࢺ࡛ࡣᢠཎ≉␗ⓗ7&5࡜ࡑࡢᶆⓗS+/$ࡢ┦஫స⏝ࢆ୍ᩧྠᐃ࡛ࡁࡿᢏ⾡ࢆ㛤Ⓨࡍࡿࡇ࡜࡟ࡼࡾࠊࡀࢇ≉␗ⓗ7&5ࢆ࡝ࡢࡼ࠺࡞ᝈ⪅࠿ࡽࡶ㎿㏿࡟Ⓨぢࡋࠊㄡ࡛ࡶᏳ඲࡟ཷࡅࡽࢀࡿ᪂つࡀࢇ㑇ఏᏊ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ୺࡞◊✲ᡂᯝᡂᯝࡢᴫせ✲       ᡂ
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௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࡑࢀࡒࢀࡢ⒴ᝈ⪅⏤᮶᳨య࡟ᑐࡋ࡚ࢫࢡ࣮ࣜࢽࣥࢢࢆ⾜࠸ࠊ⒴≉␗ⓗ 7&5 ࢆ༢㞳ࡍࡿࠋࡑࡢᚋࠊ ᖺᗘ࡟㛤Ⓨࡋࡓ S+/$ ࡢࢹ࢕ࢫࣉࣞ࢖ᢏ⾡࡜⤌ࡳྜࢃࡏࡿࡇ࡜࡟ࡼ
ࡾࠊ7&5 ࡀఱࡢ⒴ᢠཎ࠾ࡼࡧ +/$ ࢆㄆ㆑ࡋ࡚࠸ࡿࡢ࠿ࢆྠ
ᐃࡍࡿࠋࡑࡋ࡚⒴≉␗ⓗ 7&5 ࢆᑟධࡋࡓ 7 ⣽⬊ࡢ⒴ẅയຠᯝࢆ⒴⣽⬊ᰴ᳨࡛ドࡋࠊື≀ᐇ㦂࡛ࡶ⒴἞⒪ຠᯝ࠾ࡼࡧ๪స⏝ࡢࣞ࣋ࣝࢆ᳨ドࡍࡿࠋຍ࠼࡚ࠊ⭘⒆ෆᾐ₶ᢠయࢆ㓝ẕࢹ࢕ࢫࣉࣞ࢖ἲ࡛㧗㏿ࢫࢡ࣮ࣜࢽࣥࢢࡋࠊ⒴≉␗ⓗᢠయࡢ༢㞳ࢆ⾜࠺ࠋ⒴≉␗ⓗᢠయࢆ༢㞳ᚋࠊࡑࡢ⒴ẅ
യຠᯝࢆྠᵝ࡟᳨ドࡍࡿࠋ ᖺᗘࡣඹྠ◊✲ඛ࠿ࡽ⒴ᝈ⪅⏤᮶᳨య㸦⬡⫫⫗⭘ࠊ⁥⭷⫗⭘ࠊ⬺ศ໬ᆺ⬡⫫⫗⭘ࠊ⮅⮚⒴ࠊ⫵⒴㸧ࢆධᡭฟ᮶ࡓࡓࡵࠊ⒴≉␗ⓗ 7&5 ࢆ༢㞳࡛ࡁࡿ࠿࡝࠺࠿ࢆ᳨
ドࡋࡓࠋࡲࡎࠊࡑࢀࡒࢀࡢ⒴᳨య࡟ࡘ࠸࡚⣽⬊ᰴࡢస〇ࢆᐇ᪋ࡋࠊ⬺ศ໬ᆺ⬡⫫⫗⭘௨እࡢ⣽⬊ᰴࢆᶞ❧ࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋࡲࡓࠊࡑࢀࡒࢀࡢ⭘⒆ෆ࡟ᾐ₶ࡋ࡚࠸ࡿ
7 ⣽⬊࡟㸯⣽⬊ࢩ࣮ࢡ࢚ࣥࢫࢆᐇ᪋ࡋࠊ7&5 ࣞࣃࢺ࢔ࢆỴᐃࡋࡓࠋ᭦࡟ࠊᝈ⪅⏤᮶ 7&5 ࣛ࢖ࣈ࣮ࣛࣜࢆ 7 ⣽⬊ᰴ࡟ࢹ࢕ࢫࣉࣞ࢖ࡉࡏࠊᝈ⪅⏤᮶⒴⣽⬊ᰴ࡜཯ᛂࡉࡏࡿࡇ࡜
࡟ࡼࡾࠊ⒴≉␗ⓗ 7&5 ࡢ㓄ิࢆ㧗㏿࡟Ỵᐃࡍࡿࡇ࡜ࢆ⌧ᅾヨࡳ࡚࠸ࡿࠋࡲࡓࠊ⭘⒆ෆ࡟ᾐ₶ࡋ࡚࠸ࡿ % ⣽⬊ࡀ࡝ࡢࡼ࠺࡞ᢠయࢆⓎ⌧ࡋࠊఱࡢᢠཎࢆㄆ㆑ࡋ࡚࠸ࡿ࠿ࡣ࡯
࡜ࢇ࡝ゎ᫂ࡉࢀ࡚࠸࡞࠸ࠋࡑࡇ࡛ࠊ⭘⒆ෆᢠయࡢ≉ᚩࢆ
㧗㏿࡟ㄪ࡭ࡿࡓࡵ࡟ࠊ㓝ẕ࡟ࡼࡿᢠయࢹ࢕ࢫࣉࣞ࢖ᢏ⾡ࡢᐇ㦂⣔ࢆ❧ࡕୖࡆࡓࠋ⌧ᅾࠊᢠయࢹ࢕ࢫࣉࣞ࢖ᢏ⾡ࢆ⭘⒆᳨య࡟㐺⏝ࡋゎᯒࢆ㐍ࡵ࡚࠸ࡿࠋ

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୹㔝 ⚽ᓫ
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୹㔝 ཭㔛
໭ᮧ ⣖Ꮚ

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ࡀࢇච␿ࡢ⥙⨶ⓗゎᯒ࠾ࡼࡧࡑࡢ㑇ఏᏊ἞⒪࡬ࡢᛂ⏝ࡀࢇච␿ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୹㔝 ⚽ᓫ㸧ྡ㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－ 6－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ࢭࣥࢱ࣮ྡ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(3) ᅜෆእࡢ◊✲≧ἣ᫬ィ㑇ఏᏊPeriodࡢྠᐃ࡜㌿෗ࣇ࢕࣮ࢻࣂࢵࢡ௬ㄝࡢᥦၐࡣ2017ᖺࡢࣀ
࣮࣋ࣝ㈹ࡢᑐ㇟࡜࡞ࡗࡓࡇ࡜࠿ࡽࡶࠊᗈࡃࡇࡢ௬ㄝࡀཷࡅධࢀࡽࢀ࡚
࠸ࡿ୍᪉࡛ࠊ࠸ࡃࡘࡶࡢ▩┪ࡶሗ࿌ࡉࢀ࡚࠾ࡾࠊ┿ࡢ᫬ィ᣺ືᏊࢆྠ
ᐃࡍࡿࡇ࡜ࡀ࡛ࡁࢀࡤศ㔝ࢆ㉸࠼࡚ᙉ࠸࢖ࣥࣃࢡࢺࢆ୚࠼ࡿ࡜ᮇᚅ࡛
ࡁࡿࠋࡲࡓࠊᴫ᪥᫬ィ◊✲࠿ࡽ⪁໬⑕≧ࡢ᰿ᗏཎ⌮࡟㏕ࡾࡓ࠸ࠋYasuko O. Abe, Hikari Yoshitane (Co-correspondence) et al.
Nature Communications, 13 (1): 4652 (2022)
Shingo Hiroki, Hikari Yoshitane et al.
Nature Communications, 13(1): 2928 (2022)
Hikari Yoshitane (Co-correspondence) et al.
Antioxidants & Redox Signaling, Online ahead of print (2022)
Satoshi Kawakami, Hikari Yoshitane (Co-correspondence) et al.
Journal of Biochemistry, 171(5): 509-518 (2022)
Hitomi Yamamoto-Matsuda, …, Hikari Yoshitane, …, Mikiko C Siomi
EMBO Rep., 23(10): e53813 (2022)
Taira Wada, …, Hikari Yoshitane, …, Shigeki Shimba
J. Endocrinol., 254 (2): 121-133 (2022)
Takashi Ogino, …, Hikari Yoshitane, …, Shigehiro Ohdo.
Elife, 10: e66155 (2021)
Atsushige Ashimori, …, Hikari Yoshitane, …, Yasumasa Bessho
Front Neurosci., 15: 647589 (2021)(2)(1) ᴫせ⣙24᫬㛫࿘ᮇࡢࣜࢬ࣒ࢆ⏕ࡳฟࡍᴫ᪥᫬ィࡣࠊ㌿෗⩻ヂࢆ௓ࡋࡓࣇ࢕࣮
ࢻࣂࢵࢡไᚚ࡟ࡼࡾ᣺ືࡍࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡓࠋࡋ࠿ࡋᡃࠎࡣࠊ⩻ヂᚋಟ㣭ࡸᵓ㐀ኚ໬࡞࡝ࡢࢱࣥࣃࢡ㉁ࢲ࢖ࢼ࣑ࢡࢫࡀ᫬ィࡢࢡ࣮࢜ࢶ࡜ࡋ࡚
ᶵ⬟ࡍࡿ࡜⪃࠼ࠊࡑࡢศᏊ࡛ࣞ࣋ࣝࡢ⌮ゎࢆ┠ᣦࡍࠋࡉࡽ࡟ࠊ᫬ィࡀቯࢀࡿࡇ࡜࡟ࡼࡾ⪁໬⌧㇟ࡀᑟ࠿ࢀࡿ௙⤌ࡳ࡟╔┠ࡋࠊࡇࢀࢆ⌮ゎࡋ࡚ᛂ⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊᑑ࿨ࡸ⪁໬࡬ࡢศᏊ࢔ࣉ࣮ࣟࢳࢆ┠ᣦࡍࠋ࠙ᴫ᪥᫬ィࢡ࣮࢜ࢶ㸦Circadian quartz㸧ࣉࣟࢪ࢙ࢡࢺࠚ
ᴫ᪥᫬ィࡀ24᫬㛫࿘ᮇࡢࣜࢬ࣒ࢆ⏕ࡳฟࡍศᏊ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿ࠙᫬ィ⪁໬㸦Clock aging㸧ࣉࣟࢪ࢙ࢡࢺࠚ
᫬ィࡀቯࢀࡿ࡜⪁໬⌧㇟ࡀᑟ࠿ࢀࡿ௙⤌ࡳࢆ⌮ゎࡋࠊᛂ⏝ࢆ┠ᣦࡍ୺࡞◊✲ᡂᯝᡂᯝࡢᴫせ✲       ᡂ   ᯝ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼◊✲ᐊ❧ࡕୖࡆ࠿ࡽ 2 ᖺ㛫࡛ࠊ᝿ᐃ௨ୖ࡟㡰ㄪ࡟◊✲ࢆ㐍ࡵࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡇࡢࢫࣆ࣮ࢻࢆⴠ࡜ࡉࡎ࡟ࡼࡾຍ㏿࡛ࡁࡿࡼ࠺඲ຊ
࡛◊✲࡟ᡴࡕ㎸ࡳࡓ࠸ࠋ≉࡟ࠊ㌿෗ࣜࢬ࣒ࡀ࡞࠸᮲௳࡟࠾࠸࡚ࡶ
᫬ィ᣺ືࡀ⥅⥆ࡍࡿศᏊ࣓࢝ࢽࢬ࣒࡟࢔ࣉ࣮ࣟࢳࡍࡿࠋࡲࡓࠊຍ
㱋࡟కࡗ࡚᫬ィࡢฟຊࣜࢬ࣒ࡀ஘ࢀࡿࡇ࡜ࡀุ᫂ࡋࡓࡀࠊࡑࡢ௙
⤌ࡳࡀ୙࡛᫂࠶ࡿࠋࡇࡢᇶ♏ⓗ࡞⌮ゎࢆ⮫ᗋࡢ⌧ሙ࡟ᒆࡅࡿࡓࡵ
࡟ࡶࠊ᫬ィ⪁໬ࡢ᰿ᮏⓗ࡞ศᏊ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋ(2)◊✲ᐊ❧ࡕୖࡆࡢࢫࢱ࣮ࢺࢲࢵࢩࣗ࡟ᡂຌࡋࠊ2 ᖺ┠࡟ࡶᩘከࡃࡢ
ཎⴭㄽᩥࡢⓎ⾲ࢆࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋ౛࠼ࡤࠊ᫬ィධຊ⤒㊰࡜ࡋ
࡚ mTOR-AKT ࢩࢢࢼࣝࡢ㔜せᛶࢆⓎぢࡋࡓࠋࡲࡓࠊ⪁໬ࣔࢹࣝ࡜
ࡋ࡚ Lnma-KO ࣐࢘ࢫࢆ⏝࠸ࡓゎᯒ࠿ࡽࠊ᫨⾜ᛶ࡜ኪ⾜ᛶࡢࢫ࢖ࢵ
ࢳ࡟௦ㅰࣂࣛࣥࢫࡀ㔜せ࡛࠶ࡿࡇ࡜ࢆሗ࿌ࡋࡓࠋࡉࡽ࡟ࠊ᫬ィ㑇ఏᏊ Bmal1 ࡢ㌿෗ไᚚ㓄ิ࡟ὀ┠ࡋ࡚ࠊBmal1 㑇ఏᏊࡢⓎ⌧ࣜࢬ࣒ࡔࡅࢆ᏶඲࡟೵Ṇࡉࡏࡓ⣽⬊࡜࣐࢘ࢫࢆᶞ❧ࡋࠊBmal1 ࡢ㌿෗ࣜࢬ࣒ࡀ᫬ィ᣺ື࡟ᚲ㡲࡛ࡣ࡞࠸ࡇ࡜ࢆ♧ࡍ࡜࡜ࡶ࡟ࠊࡋ࠿ࡋ㐍໬ୖ࡞ࡐ Bmal1 ࡢ㌿෗ࣜࢬ࣒ࡀಖᏑࡉࢀ࡚ࡁࡓࡢ࠿ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜
ࡀ࡛ࡁࡓࠋ᫬ィ⪁໬ࡢࢥࣥࢭࣉࢺ࡛๰Ⓨⓗ◊✲࡟᥇ᢥࡉࢀࠊຍ㱋࡟క࠸᫬ィࡢ ᶵ ⬟ࡀ ◚ ⥢ ࡍ ࡿ ࣓ ࢝ ࢽࢬ ࣒ ࢆ ㏣ồ ࡋ ࡚ ࠸ ࡿ ࠋ ࡉ ࡽ ࡟ AMEDFORCE ࡟᥇ᢥࡉࢀࠊ᫬ィ⪁໬ࢆࡘ࠸࡟ࣄࢺ⮫ᗋ◊✲࡬࡜ᛂ⏝ࡍࡿ➨୍Ṍࡢ◊✲ࢆ᥎㐍ࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋ

ᴫ᪥᫬ィࢡ࣮࢜ࢶ࡟ࡘ࠸࡚ࠊ᫬ィࢱࣥࣃࢡ㉁ࡢ┦஫స⏝ࣜࢬ࣒࡜⩻ヂᚋಟ㣭ࣜࢬ࣒ࢆ࢔࣑ࣀṧᇶࡢゎീᗘ࡛ゎ᫂ࡋࡓࠋࡇࢀࡽࢱࣥ
ࣃࢡ㉁ࢲ࢖ࢼ࣑ࢡࢫ࡟╔┠ࡋ࡚ࠊ᪂つ┦஫స⏝ᅉᏊࡸ᪂つ⩻ヂᚋಟ㣭ࡀ௚ࡢࢲ࢖ࢼ࣑ࢡࢫ࡟୚࠼ࡿᙳ㡪ࢆㄪ࡭ࡿ࡜࡜ࡶ࡟ࠊ᫬ィ᣺ື࡟࠾ࡅࡿ㔜せᛶࢆホ౯ࡋ࡚࠸ࡿࠋࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮࡛࠶ࡿ
ྜྷ✀ࢆ㡿ᇦ௦⾲࡜ࡋ࡚ࠊᏛ⾡ኚ㠉㡿ᇦ Bࠕ᫬㛫ࢱࣥࣃࢡ㉁ᏛࠖࢆⓎ㊊ࡋࡓ(https://chronoproteinology.org)ࠋᙜヱࣉࣟࢪ࢙ࢡࢺࢆᡂຌࡉ
ࡏࠊࡼࡾ኱ࡁ࡞࣒࣮ࣈ࣓ࣥࢺ࡬࡜Ⓨᒎࡉࡏࡓ࠸ࠋ

(1)

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◊ ✲ ⪅ ྡ࠙◊ಟ⏕ࠚஎ㒊 ඃኴ㸦ᮾ኱ ༤ኈ2ᖺ㸧ᕝୖ ⪷ྖ㸦ᮾ኱ ༤ኈ2ᖺ㸧ගྜྷ ᝋᏊ㸦ឿᜨ ༤ኈ1ᖺ㸧ఀ⸨ ⯗ႛ㸦ᮾ኱ ಟኈ2ᖺ㸧᳃ᮧ ኴ㈗㸦ᮾ኱ ಟኈ2ᖺ㸧Ᏻ⸨ ᾴ㡢㸦ἲᨻ Ꮫ㒊4ᖺ㸧࠙ᐈဨ◊✲ဨࠚ῝⏣ ྜྷᏕ࠙㠀ᖖ໅⫋ဨࠚ಴ᯘ ள⌮Ἃ

࠙ᖖ໅◊✲ဨࠚ
ྜྷ✀ ග
಴ᯘ ఙ༤
⏣୰ ᬛᏊ
ᘅᮌ 㐍࿃
ຍ⸨ 㞷
ୖᮏ ᜤᖹ

ᴫ᪥᫬ィ࡜ᑑ࿨࣭⪁໬ࢱ࢖࣐࣮యෆ᫬ィ㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ྜྷ✀ ග㸧㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ

－ 7－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ࢭࣥࢱ࣮ྡ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(3) ᅜෆእࡢ◊✲≧ἣᮏࢭࣥࢱ࣮࡛㐍ࡵ࡚࠸ࡿࢤࣀ࣒ୖࡢ㠀㑇ఏᏊ㡿ᇦ࡟Ꮡᅾࡍࡿ⑌ᝈ㛵㐃ከᙧࡢᶵ⬟ゎᯒࡸࠊ⣽⬊ẖ࠶ࡿ࠸ࡣᚤᑠ༊⏬ẖࡢ㑇ఏᏊⓎ⌧ゎᯒࡢຠᯝⓗ࡞ά⏝ࡣࠊୡ⏺ⓗ࡟ࡶὀ┠ࡉࢀ࡚࠸ࡿ◊✲㡿ᇦ࡛࠶ࡿࠋ

ᅜ㝿Ꮫ఍Kasukawa, T. et al. IMGC2023 (2022)⥲ㄝྜྷᕝⲁࡽࠊ᪥ᮏ⢭⚄⚄⤒Ꮫ఍ㄽᩥ
Yoshizawa-Sugata, N. Masai, H. Methods Mol. Biol. 2519, 163 185 (2023).
Mukae, J. et al. Leuk. Lymphoma 63, 3261 3264 (2022).
Koido, M. et al. Nat Biomed Eng (2022).
Nakagawa, R. et al. Hum. Mol. Genet. 31, 2223 2235 (2022).
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Das, S. K., et al. Mol. Cell 82, 140 158.e12 (2022).
Gotoh̺Saito, S. et al. Genes to Cells 27, 689̽705 (2022)(2)(1) ᴫせࢤࣀ࣒ࡢᶵ⬟ࠊ≉࡟㑇ఏᏊࡢⓎ⌧ไᚚ࡟㛵ࡍࡿᶵ⬟ࢆ᫂ࡽ࠿࡟ࡍࡿ
ࡇ࡜࡛་⒪࣭๰⸆࡬㈉⊩ࡍࡿ࡜ඹ࡟ࠊࣉࣟࢪ࢙ࢡࢺ◊✲ࡸ㒔❧⑓㝔➼࡟࠾ࡅࡿࢤࣀ࣒ゎᯒᢏ⾡ࡢຠᯝⓗ࡞ά⏝ࢆ┠ᣦࡋࡓ㐃ᦠ◊✲ࡢ᥎㐍ࢆ┠ⓗ࡜ࡍࡿࠋᐇ㦂 ᐃ࠶ࡿ࠸ࡣ᝟ሗゎᯒࡢࡑࢀࡒࢀ࡟ᑓ㛛ࢆᣢࡘ8ྡࡢ◊✲ဨ࡛ᵓᡂࡉࢀࡿయไࡢୗࠊ㌿෗ไᚚ㡿ᇦࡢゎ᫂࡜ᶵ⬟ゎᯒࠊ㛗㙐
RNA㓄ิゎᯒࢆࡣࡌࡵ࡜ࡍࡿ᰾㓟་⸆㛤Ⓨᇶ┙ࡢ⥔ᣢ࣭ᨵၿࢆ᥎㐍ࡋࡓࠋࡇࢀ࡜ඹ࡟ࠊ⣽⬊ẖ࣭ᚤᑠ༊⏬ẖࡢ㑇ఏᏊⓎ⌧ゎᯒࡸࠊࢤࣀ࣒ᵓ
㐀࡟㛵ࡍࡿ኱つᶍィ⟬ゎᯒᢏ⾡➼ࢆ⏝࠸ࡓ㐃ᦠ◊✲ࢆࠊࣉࣟࢪ࢙ࢡࢺ
◊✲ࡸ㒔❧⑓㝔࡜ඹ࡟ᒎ㛤ࡋࡓࠋ୺࡞◊✲ᡂᯝ

඲㛗 RNA ࡢ㓄ิゎᯒᢏ⾡࡜ࡋ࡚ࠊ㛗㙐 cDNA ࡢㄪ〇࡜ṇ☜࡞ሷᇶ㓄ิỴᐃ࠾ࡼࡧᶆⓗ⃰⦰ᢏ⾡ࡢᴫᛕᐇドࢆ⾜࠺࡜ඹ࡟ࠊ
᰾㓟་⸆ရ㛤Ⓨࡢᇶ┙ࢹ࣮ࢱࢆᏳᐃⓗ࡟ᥦ౪ࡋࡓࠋ
࣐࢘ࢫ࣭ࣄࢺ⬻Ⓨ⏕᫬ࡢ✵㛫ࢺࣛࣥࢫࢡࣜࣉࢺ࣮࣒ゎᯒ(⬻⚄⤒ᅇ㊰ᙧᡂ PJ)ࠊ኱つᶍ࡞୍⣽⬊Ⓨ⌧ゎᯒࢹ࣮ࢱ⤫ྜゎᯒ(⬻༞୰ PJ)ࠊ㦵㧊⮫ᗋ᳨య୍⣽⬊ゎᯒ(㥖㎸⑓㝔)ࠊ⤫ྜኻㄪ⑕ᝈ
⪅ࢤࣀ࣒ࡢࢥࣆ࣮ᩘኚ໬ゎᯒ (Yoshikawa et al., 2022 ⤫ྜኻㄪ
⑕ PJ)ࠊⓑ⾑⑓⣽⬊ࡢච␿࢚ࢫࢣ࣮ࣉᶵᵓࡢゎᯒ(㥖㎸⑓㝔 ⾑ᾮෆ⛉)ࠊᕧ⣽⬊ᛶື⬦⅖ (ከᦶ໭㒊་⒪ࢭࣥࢱ࣮) ࢆࡣࡌࡵ࡜ࡍࡿඹྠ◊✲ࢆ᥎㐍ࡋࡓ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼᪂つ࡟ྠᐃࡋࡓࢩࢫ࢚࣓ࣞࣥࢺ࠾ࡼࡧࡑࡢᶆⓗࠊࡲࡓࠊ㛤Ⓨࡋࡓ ᐃ࣭ゎᯒᢏ⾡࡟㛵ࡍࡿ◊✲ሗ࿌ࢆ㐍ࡵࡿ࡜ඹ࡟ࠊ㛤Ⓨ୰ࡢᢏ⾡ࢆ᏶ᡂࡉࡏࡿࠋ
᰾㓟་⸆ရࡢᏳ඲ᛶ࣭᭷ຠᛶホ౯࡟ཧ↷ࡉࢀ࡚࠸ࡿࢹ࣮ࢱ࣋
࣮ࢫࡢ඘ᐇࢆᅗࡿࡓࡵࠊ⑌ᝈ࡟࠾ࡅࡿ RNA ඲㛗ሷᇶ㓄ิࡢᐃ࡟╔ᡭࡍࡿࠋ
᪤࡟࠶ࡿ㐃ᦠ◊✲ࢸ࣮࣐ࢆ᥎㐍ࡍࡿ࡜ඹ࡟ࠊ᪂ࡓ࡞㐃ᦠࢆᶍ
⣴ࡍࡿࠋ

࣭

࣭

(2)
࣭

࣭

࣭

࣓ࢵࢭࣥࢪ࣮ࣕRNA ࡸ㠀ࢥ࣮ࢻ RNA ࡢ㌿෗㛤ጞⅬࢆᐃ㔞ⓗ࡟ᐃࡍࡿ CAGE ἲࢆ⏝࠸ࡿࡇ࡜࡛ྠᐃࡋࡓࠊ⸆๣ᛂ⟅ⓗ࡟άᛶ໬ࡉࢀࡿࢩࢫ࢚࣓ࣞࣥࢺೃ⿵࡟ࡘ࠸࡚ࠊࡑࡢάᛶ࡜ᶆⓗ㑇ఏᏊࢆᐇ㦂ⓗ࡟♧ࡋࡓࠋࡲࡓࠊࢩࢫ࢚࣓ࣞࣥࢺࡢᶆⓗྠᐃࢆࡼࡾຠᯝⓗ࡟ᐇ⌧ࡍࡿࡓࡵࠊᶆⓗண ࡟㛵ࡍࡿィ⟬ᡭἲ࠾ࡼࡧ࢚ࣆࢤࣀ࣒⦅㞟ᢏ⾡࡟㛵ࡍࡿ᪂ᢏ⾡ࡢᴫᛕᐇドࢆ⾜࠸ࠊ௵ពࡢ DNA ሷᇶ㓄ิࡢ㌿෗ไᚚάᛶࢆ ᐃࡍࡿ㉸୪ิ࣏࣮ࣞࢱ
࣮࢔ࢵࢭ࢖ࢆ⏝࠸ࡓ ᐃᣑ኱ࠊࡲࡓࢩࢫ࢚࣓ࣞࣥࢺ࣭ࢹ࣮ࢱ
࣮࣋ࢫࡢᵓ⠏࡟╔ᡭࡋࡓࠋ

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ࢤࣀ࣒་Ꮫ◊✲ࢭࣥࢱ࣮㸦๪ࢭࣥࢱ࣮㛗㸸ᕝ㊰ⱥဢ㸧✲⪅䠄◊ಟ⏕㻕㻌ᅄ᪉ 㐩ஓ䠄༠ຊ◊✲ဨ㻕㻌
㔠ᨻ భ඾
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㻔㠀ᖖ໅⫋ဨ㻕㻌᳃ ⿱Ꮚ࿴⏣ ᾴᏊᖹ㛫 ༓ὠᏊᑠᕝ ⨾ዉ䠄ᖖ໅◊✲ဨ䠅ṇ஭ ஂ㞝䠄ව䠅ᕝ㊰ ⱥဢ
኱ಖᮌ ၨ௓
Ώ㑔 ఙᫀ
ྜྷἑ ┤Ꮚ
ኟ┠㇏ᙲ
ཎ 㞝୍㑻
㰺⸨ ⣪ᕼ
㻴㼑㼠㼠㼕㼍㼞㼍㼏㼔㼏㼔㼕㻌㻺㼕㼘㼙㼕㼚㼕㻌◊ྡ㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ－－◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊       ✲       ᡂ       ᯝ♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮㸭ᚰࡢ೺ᗣࣘࢽࢵࢺ
㸦ࣘࢽࢵࢺ࣮ࣜࢲ࣮㸸す⏣῟ᚿ㸧ࢀࡓᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ4᫬Ⅼ⦪᩿ࢹ࣮ࢱࢆ⏝࠸࡚ࠊRI-CLPM࡞࡝ࡢ⤫ィᡭἲࢆ㥑౑ࡋࡓᅉᯝ᥎ㄽ◊✲ࡶྍ⬟࡜࡞ࡾࠊࡑࡢᏛ⾡ⓗ౯್ࡀ㧗ࡲࡗ࡚࠸
ࡿ(Stanyon D et al., Schizophr Bull, 2023)ࠋᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺࡢࢹ࣮ࢱࡢ
౑⏝ࢆᕼᮃࡍࡿᾏእ◊✲⪅ࢆ✚ᴟⓗ࡟ᣍ⪸ࡋࠊᾏእࢥ࣮࣍ࢺ࡜ࡢ㐃ᦠ◊✲ࡀ୍ᒙ᥎㐍ࡉࢀ࡚࠸ࡿ㸦DeVylder J et al., Schizophr Bull, 2023㸧ࠋࡲࡓࠊᮾி
㒔┘ᐹ་ົ㝔࡜ࡢ㐃ᦠ࡟ࡼࡿ║ᡣỈࢆ⏝࠸ࡓ◊✲࡟ࡼࡾࠊ⮬ẅ࡜యෆᚤ㔞ࣜࢳ࣒࢘࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟(Ando S et al., Transl Psychiatry,2022) ࠊᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ᳨యࢆ⏝࠸ࡓࣜࢳ࣒࢘◊✲ࡶ╔ᐇ࡟㐍ᒎࠋ࣭ 㒔ᨻ┤⤖ᆺ◊✲࡜ࡋ࡚᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁᣑ኱ࢆᢚ࠼ࡿࡓࡵࡢࠕேὶ
ࣔࢽࢱࣜࣥࢢࢩࢫࢸ࣒ࠖࢆ㛤Ⓨࡋࠊᙜࢭࣥࢱ࣮ࡀཧ⏬ࡍࡿᮾி㒔iCDCᑓ㛛ᐙ࣮࣎ࢻ␿Ꮫ࣭බ⾗⾨⏕ࢳ࣮࣒㸦ி㒔኱Ꮫ࣭すᾆᩍᤵ㸧࡜ࡶ㐃ᦠࡋࡘࡘࠊࣁ ࢖ ࣜ ࢫ ࢡ ே ὶ ࡜ ឤ ᰁ ≧ ἣ ࡜ ࡢ 㛗 ᮇ ⓗ 㛵 㐃 ࢆ ᫂ ࡽ ࠿ ࡟ ࡋ ࡓ 㸦 Okada
Yamasaki et al., under review㸧ࠋㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛ◊✲ࡣࠊCOVID-19ࡢ
ὶ⾜ୗ࡛ࡶ◊ಟࢆຠᯝⓗ࡟ᒎ㛤ࡋ࡚࠸ࡃࡓࡵࡢ࢜ࣥࣛ࢖ࣥࢩࢫࢸ࣒ࢆ㛤Ⓨࠋᚑ᮶ࡢ◊ಟ࡜ྠ⛬ᗘࡢຠᯝࡀ࠶ࡿࡇ࡜ࢆ☜ㄆࡋࠊ㒔ෆ㸲㸰ࡢ⮬἞య࡟ᬑཬࠋᮾி㒔࠾ࡼࡧ4ࡘࡢ⮬἞య࡜㐃ᦠࡋࠊඣ❺⹢ᚅࡢᮍ↛㜵Ṇࢣ࢔ࣉࣟࢢ
࣒ࣛࡢ㛤Ⓨࡋࠊຠᯝ᳨ド◊✲ࢆ㛤ጞࠋࣜࢡ࣮ࣝࢺ᏶஢ࠋ

(3)ᅜෆእࡢ◊✲≧ἣ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࣉࣟࢪ࢙ࢡࢺࡣࢃࡀᅜึ࡛࠶ࡾࠊᛮ
᫓ᮇࢆ⦪᩿㏣㊧ࡋࠊ⢭⚄⑓⌮➼ࡢᙧᡂࣉࣟࢭࢫ࡟ᙳ㡪ࢆ୚࠼ࡿせ ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ᅉ➼ࢆゎ᫂ࡍࡿព⩏ࡣ኱ࡁ࠸ࠋㄆ▱⑕ࡢேࡢ⾜ືᚰ⌮⑕≧ࢣ࢔ࣉ ࣭ ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࡢ20ṓ᫬ㄪᰝࢆ⥅⥆ࡍࡿࠋㄆ▱⑕ࢣ࢔ࣉࣟࢢࣛ
ࣟࢢ࣒ࣛࡢ♫఍ᐇ⿦࡟㛵ࡍࡿ◊✲ࠊ࠾ࡼࡧඣ❺⹢ᚅண㜵࡟㛵ࡍࡿ࣒ࡢࡉࡽ࡞ࡿᬑཬ࡟ྥࡅᮾி㒔࠾ࡼࡧ༠ຊ⮬἞య࡜㐃ᦠࡍࡿࠋඣ❺⹢ᚅண◊✲ࡣྛᅜ᪋⟇ࡢ↔Ⅼ࡜ࡶ࡞ࡗ࡚࠾ࡾࠊᡃࡀᅜ࡛ྲྀࡾ⤌ࢇ࡛࠸ࡿ㜵࡟㛵ࡍࡿዷፎᮇ࠿ࡽࡢᐙ᪘ᨭ᥼ࢩࢫࢸ࣒࡜ࡑࢀࢆᢸ࠺ேᮦࡢ⫱ᡂࣉࣟࢢ࣒ࣛࢆ㛤Ⓨࡋࠊࡑࡢຠᯝ᳨ド◊✲ࢆ㐍ࡵࡿࠋᶵ㛵ࡣஈࡋ࠸ࠋCOVID-19ࡢឤᰁ≧ἣࢆண ࡍࡿࡓࡵࡢேὶࣔࢽ
ࢱࣜࣥࢢࢩࢫࢸ࣒ࡢ㛤Ⓨ࡜⛉Ꮫⓗ᳨ドࡶႚ⥭ࡢ♫఍ㄢ㢟࡛࠶ࡿࠋ࣭ ᮾி㒔⚟♴ಖ೺ᒁ㛗⾲ᙲ㸦2022ᖺ3᭶㸧(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Stanyon D et al (2023) Schizophr Bull, 49:329-338.
࣭ DeVylder J et al (2023) Schizophr Bull, 49:385-396.
࣭ Ando S et al (2022) Transl Psychiatry, 12:466.
࣭ Nakanishi M et al (2022) J Adolesc Health., 70:877-884.
࣭ Nakanishi M et al (2022) J Alzheimers Dis, 88:493-502.
࣭ Niimura J et al (2022) Soc Psychiatry Psychiatr Epidemiol. 57:2207-2215.
࣭ Endo K et al (2022) Front Psychiatry. 13:806669.
࣭ Hosozawa M et al (2022) Child Adolesc Psychiatry Ment Health. 16:107.
࣭ Tabata K et al (2022) Schizophrenia (Heidelb). 8:107.
࣭ Suzuki K et al (2022) Schizophrenia (Heidelb). 8:44.

(1)

✲

⪅

ྡ

㸦◊✲ဨ㸧
す⏣῟ᚿ
ᒣᓮಟ㐨
ᐑୗගᘯ
㤿ሙ㤶㔛
᪂ᮧ㡰Ꮚ
㐲⸨㤶⧊
ᒣཱྀᬛྐ
୰ᓥ┤⨾
Dan StanyonᏳ⸨ಇኴ㑻㸦ᐈဨ㸧ᑠụ㐍௓㸦ᐈဨ㸧㕥ᮌ ⚽ே㸦ᐈဨ㸧ᐑᮏ᭷⣖㸦ᐈဨ㸧୰す୕᫓㸦㠀ᖖ໅㸧㸦㐃ᦠ◊✲ဨ㸧
ྂᕝኖு
Ᏹబ⨾្

◊

㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾᴫせ(1) ᡂᯝࡢᴫせᚰࡢ೺ᗣࡣࠊಶேࡢ⏕άࡢ㉁ࢆ኱ࡁࡃᕥྑࡍࡿࠋࡇ࡜࡟኱㒔ᕷ ࣭ ♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮ࡀᥖࡆࡿ3ࡘࡢ࣑ࢵࢩࣙࣥࠊ༶ࡕࠊձ㛗ᮇⓗᒎᮃ࡟❧ࡗࡓ⊂⮬◊✲㸦ᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ㸧ࠊղ㠉᪂ⓗᡂᯝࢆ┠ᣦࡍᡤෆࡢ⏕ά⪅ࡣࠊᚰࡢ೺ᗣࢆ⼃ࡴࡉࡲࡊࡲ࡞せᅉ࡟᫹ࡉࢀࡿࠋᑡᏊ㧗㐃ᦠ◊✲㸦ࢥ࣮࣍ࢺ᳨యࢆά⏝ࡋࡓᡤෆඹྠ◊✲㸧ࠊճ㒔ᨻ┤⤖ᆺ◊✲㱋໬ࡀ㐍ࡴᮾி࡟࠾࠸࡚ࠊᏊ࡝ࡶ࣭ⱝ⪅ࡢ࣓ࣥࢱࣝ࣊ࣝࢫࡸ⮬㸦ඣ❺⹢ᚅண㜵ࣉࣟࢢ࣒ࣛ◊✲ࠊ᪂ᆺࢥࣟࢼேὶศᯒࠊㄆ▱⑕ࢣ࢔ࣉࣟࢢ
ẅࠊㄆ▱⑕ࢆࡣࡌࡵ࡜ࡍࡿᚰࡢ೺ᗣၥ㢟ࡣࠊ㒔Ẹࡢࡃࡽࡋ࡜೺ᗣ
࣒ࣛ◊✲㸧࡟ࡑࡗ࡚⢭ຊⓗ࡟◊✲άືࢆᒎ㛤ࡋࠊ2022ᖺᗘࡶ23⦅ࡢㄽᩥ࡟㛵ࢃࡿႚ⥭ࡢၥ㢟࡛࠶ࡿࠋ༊࣭ᕷ࡜㐃ᦠࡋࡓ኱つᶍฟ⏕ࢥ࣮࣍㸦ᅜ㝿ㄅ㸧ࢆⓎ⾲ࡋࡓࠋࢺ◊✲࡟ࡼࡿⱝ⪅ࡢ⢭⚄ⓗ೺ᗣࡸ࢙࣭࢘ࣝࣅ࣮࢖ࣥࢢ࡟㛵ࡍࡿᐇドⓗᡂᯝࡸ⮫ᗋ࣭ࢣ࢔⌧ሙ࡜ࡢ༠ാ࡟ࡼࡿㄆ▱⑕࣭⹢ᚅண㜵ࡢᆅ ࣭ ᪂ࡓ࡟኱ᆺ◊✲㈝㸦Ꮫ⾡ኚ㠉㡿ᇦ㸦A㸧㸧ࢆ⋓ᚓࡋࠊᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ
20ṓ᫬ㄪᰝࢆ㛤ጞࠋ20ṓ᫬ㄪᰝ࡛ࡣࠊᡞูゼၥㄪᰝࡢࡳ࡞ࡽࡎࠊ᮶ᡤᆺㄪ
ᇦࢣ࢔ࣉࣟࢢ࣒ࣛ㛤ⓎࠊCOVID-19ேὶศᯒ➼ࠊ♫఍་Ꮫ◊ⓗ᪉ᰝࡶ࠶ࢃࡏ࡚ᐇ᪋ࡋࠊᗈ⠊ᅖ࡞ࣂ࢖࣐࣮࣮࢜࢝ࢆ཰㞟ࡍࡿࠋࡍ࡛࡟཰㞟ࡉἲ࡟ࡼࡿᚰࡢ೺ᗣ࡙ࡃࡾ◊✲ࡢ♫఍㑏ඖࡀồࡵࡽࢀ࡚࠸ࡿࠋ

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ᴫせ
ALSࡢࢣ࢔┳ㆤ◊✲࡟㛵ࡍࡿࡇࢀࡲ࡛ࡢᐇ⦼ࢆᇶ┙࡜ࡋࡘࡘࠊ
ࡑࡇ࡛ᇵࡗ࡚ࡁࡓ⒪㣴⎔ቃࡢᩚഛࡸ┳ㆤᢏ⾡ࡢྥୖ➼࡟㛵ࡍࡿࣀ࢘ࣁ࢘ࢆࠊ⚄⤒㞴⑓࡟㝈ࡽࡎ㞴⑓඲య࡟ỗ⏝ࡋ࡚࠸ࡃࡓࡵࡢ◊✲ࢆ⾜࠺ࠋேᕤ࿧྾ჾ౑⏝⪅࣮࢜ࣉࣥࢥ࣮࣍ࢺ஦౛ࡢ⵳✚࠿ࡽࡇࢀࡲ࡛▱ࡽࢀ࡚ࡇ࡞࠿ࡗࡓ㠀㐠ື⑕≧࡟ࡘ࠸࡚ࡢ཰㞟࡜ᶵᗎゎ᫂࡟ࡘ࠸࡚⑓⌮Ꮫⓗぢゎࢆྵࡵ⾜࠺ࠋᑓ㛛እ᮶ࢆᣐⅬ࡜ࡋࡓ㏣㊧ㄪᰝ࡟ࡼࡗ࡚ࠊ⑌ᝈ⤒㐣࡟࡜ࡶ࡞࠺⒪㣴⏕άࢽ࣮ࢬࡢኚ㑄ࢆ⦪᩿ⓗ࡟᫂ࡽ࠿࡟ࡋࠊຠᯝⓗ࡞┳ㆤࢣ࢔ࣉࣟࢢ࣒ࣛࡢලయ໬ࢆ┠ᣦࡍࠋ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ࢭࣥࢱ࣮ྡᡂᯝࡢᴫせ✲       ᡂ
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࣭ேᕤ࿧྾⒪㣴⪅ࡢࢹ࣮ࢱ࣮࣋ࢫᵓ⠏㸸ALS ᅾᏯேᕤ࿧྾⿦╔⪅ࡢ⤒㐣㏣㊧ㄪᰝࢆ⥅⥆ࡋࠊẼ⟶ษ㛤㸦TIV㸧ㄪᰝᑐ㇟⣼ィ 100 ྡ࡜࡞ࡗࡓࠋ඲⤒㐣ࢥ࣮࣍ࢺᵓ⠏ࡢ୍⎔࡜ࡋ࡚ࠊ2010 ᖺ௨㝆ࡢ A ⑓㝔ධ㝔ᝈ⪅࡛ࡢேᕤ࿧྾⟶⌮ࡢᐇ᪋≧ἣࢆᚋࢁྥࡁ࡟ㄪᰝࡋࡓࠋㄪ
ᰝᮇ㛫ෆࡢேᕤ࿧྾ჾ⟶⌮ᐇ౛ࡣ 1,033 ࠶ࡾࠊ࠺ࡕ ALS ࡣ 368 ౛
࡛࠶ࡗࡓࠋ

(1)

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⪅

୰ᒣඃᏘ㸦་Ꮫ◊㸧ཎཱྀ㐨Ꮚ(་Ꮫ◊)ᯇ⏣༓᫓㸦་Ꮫ◊㸧ᑠ಴ᮁᏊ(་Ꮫ◊)ᯈᇉࡺࡳ㸦་Ꮫ◊㸧ᕝᮧబ࿴Ꮚ(་Ꮫ◊)ΎỈಇኵ(⚄⤒⑓㝔)ᑠ᳃㝯ྖ(⚄⤒⑓㝔)ᮌ⏣⪔ኴ(⚄⤒⑓㝔)

◊

✲

ྡ

㸰㸮㸰㸱ᖺ㸱᭶㸱㸯᪥⌧ᅾ♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮㸭㞴⑓ࢣ࢔┳ㆤࣘࢽࢵࢺ
㸦ࣘࢽࢵࢺ࣮ࣜࢲ࣮㸸୰ᒣඃᏘ㸧࣭⑓⌮ࢹ࣮ࢱ࣮࣋ࢫ࡜⫵ྜే⑕㸸㐃⥆๗᳨౛ࡢ୰࠿ࡽ 10 ᖺ௨ୖࠊTIV ࢆ⾜ࡗࡓ 12 ⑕౛ࢆᑐ㇟࡟⫵ࡢ⤌⧊ᡤぢࢆ᳨ウࡋࡓࠋ⫵Ẽ⭘ࠊ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
ჾ㉁໬⫵⅖ࠊ⬚⭷ࡢ⫧ཌ⥺⥔໬࡟ຍ࠼࡚ࠊ⾑⟶ቨࡢ⥺⥔໬࡜୰⭷ㄽᩥᖹ⁥➽ࡢኚᛶࡀඹ㏻ࡋࡓᡤぢ࡜ࡋ࡚ㄆࡵࡽࢀࡓࠋ⮫ᗋⓗ࡟ࡣ TIV
࣭ Matsuda C, Shimizu T , Nakayama Y et al. Neurological Sciences ,ࡢ⤊ᮎᮇ࡟ࡣ⬚⭍ෆᅽࡀᚎࠎ࡟ୖ᪼ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊ⫵2023.
࣭Kamei T, Yamamoto Y, Nakayama Y et al. Annals of Mixed Methods 㧗⾑ᅽ⑕࡟㢮ఝࡋࡓ⑓ែࡀ⫼ᬒ࡟Ꮡᅾࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ
Research. 2022(2).111-135.
࣭TIV ᮇࡢ௦ㅰ␗ᖖ㸸デ᩿᫬-Ẽ⟶ษ㛤᫬-᭱⤊ㄪᰝ᫬Ⅼ࡛ࡢᢞ୚࢝
࣭ Nakayama Y, Shimizu T , Matsuda C et al. Metabolites 2022, Volume
࣮ࣟࣜཬࡧ⾑ᾮᏛⓗᰤ㣴ᣦᶆ㸦TP,Alb,TG,TC,Glu㸧ࡢ᥎⛣ࢆࢫࢸ
12, Issue 2, 191
࣮ࢪู࡟᳨ウࡋࠊࢫࢸ࣮ࢪ V ࡛ࡣẼ⟶ษ㛤ᚋ࡟ᰤ㣴ᢞ୚㔞ࡀῶࡗⓎ⾲Ꮫ఍㸦ᣍ⪸ࡢࡳ㸧࡚࠸ࡿ࡟ࡶ࠿࠿ࢃࡽࡎ BMI ࡣቑຍࡋࠊALB ࡀ᭱ࡶపୗࡋ࡚࠸ࡿࡇ
࣭୰ᒣඃᏘ.➨63 ᅇ᪥ᮏ⚄⤒Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘
࡜ࡀ♧ࡉࢀ௦ㅰ␗ᖖࡣࢫࢸ࣮ࢪ࡟ࡼࡾ␗࡞ࡿྍ⬟ᛶࢆ⿬௜ࡅࡓࠋ࣭ ୰ᒣඃᏘ. ➨27 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ࢩ࣏ࣥࢪ࣒࢘
࣭⒪㣴⾜⛬࡟ᇶ࡙ࡃࢣ࢔ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨ࡜ࡋ࡚ࠊ㞴⑓ࡢ⥅⥆ⓗ࣭ ୰ᒣඃᏘ. ➨4ᅇ᪥ᮏᅾᏯ་⒪㐃ྜᏛ఍ࢩ࣏ࣥࢪ࣒࢘⒪㣴ᨭ᥼యไࡢయไ࣭ᶵ⬟࡜ࡋ࡚ࠊᨭ᥼ᶵ㛵㛫ࡢᵓᡂせ⣲࠾ࡼࡧ(3) ᅜෆእࡢ◊✲≧ἣ㐃ᦠࡢᒁ㠃ࡢ≉ᚩࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
ཎᅉ✲࣭᫂἞⒪ἲ㛤Ⓨ࡟ྥࡅࡓྲྀࡾ⤌ࡳࡀ๓㐍ࡋ࡚࠾ࡾࠊ㐍⾜࣭㞴⑓ࡢᆅᇦࢣ࢔ࢩࢫࢸ࣒ࡢᵓ⠏࡟ᚑ஦ࡍࡿ඲ᅜࡢ㒔㐨ᗓ┴➼ࡢᢚไࡸணᚋࡢ㐍ᒎࡀᮇᚅ࡛ࡁࡿ㌿᥮ᮇࢆ㏄࠼࡚࠸ࡿࠋ
ಖ೺ᖌࢆᑐ㇟࡟ࠊ◊✲ᡂᯝࡢᬑཬ࠾ࡼࡧᚲせ࡞ไᗘ➼ࡢ᝟ሗࡸά㞴 ⑓ ་ ⒪ ἲ ࡢ ᪋ ⾜ 㸦 2015 㸧 ࡜ ࡑ ࡢ ぢ ┤ ࡋ ࡸ 㞀 ᐖ ⪅ ᕪ ู ゎ ᾘ ἲື᪉ἲ➼ࢆᏛࡪ་Ꮫ◊ኟࡢࢭ࣑ࢼ࣮ࢆ㸵᭶ᮎ࠿ࡽ㸷᭶ᮎ࡟ web 㛤㸦2016㸧ࠊ་⒪ⓗࢣ࢔ඣἲ㸦2021㸧 ࡞࡝ࠊ♫఍᝟ໃࡢ኱ࡁ࡞㌿᥮ദࡋࡓࠋᮇࡢ୰ࠊ᫬௦࡟༶ࡋࡓಖ೺࣭་⒪࣭⚟♴ࡢ㐃ᦠ࡟ࡼࡿࢧ࣮ࣅࢫᥦ
౪యไࡢ☜❧ࡀᚲせ࡛࠶ࡿࡀࠊ㞴⑓࡟࠾࠸࡚ࡇࢀࡽࢆ⤫ྜࡋࡓ◊(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼✲άືࢆ⾜ࡗ࡚࠸ࡿ᪋タࡣࠊᙜᡤࢆ࠾࠸࡚௚࡟࡞࠸ࠋ
㒔❧⚄⤒⑓㝔࡜ඹྠࡋࠊデ᩿᫬࠿ࡽ⒪㣴ᮇ඲యࡢ㏣㊧ࢥ࣮࣍ࢺேᕤ࿧྾⒪ἲࡢᬑཬ࣭㛗ᮇ໬࡟కࡗ࡚⏕ࡌࡓ᪂ࡓ࡞ၥ㢟(㠀㐠ືయไࡢᵓ⠏࡜௒ࡲ࡛▱ࡽࢀ࡚ࡇ࡞࠿ࡗࡓ
ALS ࡟㛵ࡍࡿ㠀㐠ື⑕≧⑕≧)ࡸᇶ♏⮫ᗋ◊✲ᡂᯝ࡟ࡼࡗ࡚᫂ࡽ࠿࡜࡞ࡗ࡚ࡁ࡚࠸ࡿㄢ㢟ࢆࡢ᥈⣴࡟⧅ࡆࡿࠋࡉࡽ࡟ࠊࡇࢀࡽࡢᡂᯝࢆࢹ࣮ࢱ࣮࣋ࢫ࡜ࡋ࡚ࠊ
ඞ᭹ࡍࡿࡓࡵࡢ┳ㆤࢣ࢔ᢏ⾡ࡢ㛤ⓎࡀồࡵࡽࢀࠊALSࢆࣔࢹࣝ࡟
⵳✚࣭Ⓨಙࡍࡿࡇ࡜ࠊཷク◊ಟࡸኟࡢࢭ࣑ࢼ࣮࡞࡝ࡢᬑཬ஦ᴗࢆ
㞴⑓඲⯡࡟ᛂ⏝ࡋ࡚࠸ࡃࡇ࡜ࡀồࡵࡽࢀ࡚࠸ࡿࠋ
㏻ࡌ࡚ࠊᅜෆእ࡛ࡢ㛵ಀ⫋✀ࡢ◊ಟ࣭ࢫ࢟ࣝ࢔ࢵࣉ࡟ᐤ୚ࡍࡿࠋ

(1)୺࡞◊✲ᡂᯝ

◊✲άື 㸦2022 ᖺᗘ㸧

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   㸦஧㔜ୗ⥺㸧 㒔ὴ㐵◊✲ဨ࣭ᅛ᭷ᖖ໅◊✲ဨ࣭እ㒊ᨭ᥼ᖖ໅◊✲ဨ   㸦୍㔜ୗ⥺㸧 㠀ᖖ໅◊✲ဨ㸦෌㞠⏝◊✲ဨྵࡴ㸧࣭㠀ᖖ໅◊✲⿵ຓဨ࣭እ㒊ᨭ᥼㠀ᖖ໅◊✲ဨ࣭◊ಟ⏕ࣉࣟࢪ࢙ࢡࢺྡ

ࢤࣀ࣒ືែࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 12 ௳㸧1.

Toshiaki Nakano, Takahito Moriwaki, Masataka Tsuda, Misa Miyakawa, Yuto Hanaichi, Hiroyuki
Sasanuma, Kouji Hirota, Masanobu Kawanishi, Hiroshi Ide, Keizo Tano, Tadayoshi Bessho.
(2022) SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-ƍ-deoxycytidine-Induced
Genomic Instability in Human TK6 Cell Line. Chemical Research in Toxicology, 35(11): 20592067, 20221025. (doi.org/10.1021/acs.chemrestox.2c00213)

2.

Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki
Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi,
Takuro Sunada, Shusuke Akamatsu, Gang He, Junji Itou, Masakazu Toi, Mary Miyaji, Kimiko M.
Tsutsui, Scott Keeney, Shintaro Yamada. (2022) ATM suppresses c-Myc overexpression in the
mammary epithelium in response to estrogen. Cell Reports, 42,(1):11909.,(doi.org/10.1016/j.celrep.2022.111909)

3.

Salma Akter, Akihiro Shimba, Koichi Ikuta, Rasel Al Mahmud, Shintaro Yamada, Hiroyuki
Sasanuma, Masataka Tsuda, Masakatsu Sone, Yukio Ago, Kenichi Murai, Hisashi Tanaka,
Shunichi Takeda. (2022) Physiological concentrations of glucocorticoids induce pathological
DNA double strand breaks. Genes to Cells, 28(1): 53-67, 20221122. (doi.org/10.1111/gtc.12993)

4.

Hideaki Nakamura, Hiroki Sekine, Hiroyuki Kato, Hisao Masai, Katarina Gradin, Lorenz
Poellinger. (2022) Hypoxia-inducible factor-ĮDQGSRO\>$'3ULERVH@SRO\PHUDVHFRRSHUDWLYHO\regulate Notch3 expression under hypoxia via a noncanonical mechanism. Journal of Biological
Chemistry, 298,7: 102137-102137, 202207 (doi.org/10.1016/j.jbc.2022.102137)

5.

Naoko Yoshizawa-Sugata, Hisao Masai. (2023) Histone Modification Analysis of LowMappability Regions. Methods in molecular biology (Clifton, N.J.), 2519, 163-185.
(doi.org/10.1007/978-1-0716-2433-3 18)

6.

Hao- en Hsiao, Chi-Chun Yang, Hisao Masai. (2023) Claspin-Dependent and -Independent
Chk1 Activation by a Panel of Biological Stresses. Biomolecules, 13,1: 125-125, 20230107.
(doi.org/10.3390/biom13010125)

－

－

7.

Chi-Chun Yang, Hisao Masai. (2023) Claspin is Required for Growth Recovery from SerumStarvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells. Molecular
and Cellular Biology, 43,1: 1-21, 20230102 (doi.org/10.1080/10985549.2022.2160598)

8.

endi Sun, Kian Leong Lee, Lorenz Poellinger, Hisao Masai and Hiroyuki Kato (2023)
Catalytic domain-dependent and -independent transcriptional activities of the tumor suppressor
histone H3K27 demethylase UT /KDM6A in specific cancer types. Epigenetics 18(1):2222245.
(doi: 10.1080/15592294.2023.2222245)

9.

Yutaka Kanoh, Seiji Matsumoto, Masaru Ueno, Motoshi Hayano, Satomi Kudo, Hisao Masai.
(2023) Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic
defect and cell death. Life Science Alliance 6(4):e202201603. (doi:10.26508/lsa.202201603)

10. Maki Sakurada-Aono, Takashi Sakamoto, Masayuki Kobayashi, Yoko Takiuchi, Fumie Iwai,
Kohei Tada, Hiroyuki Sasanuma, Shigeki Hirabayashi, Yasuhiro Murakawa, Kotaro Shirakawa,
Chihiro Sakamoto, Keisuke Shindo, Jun-Ichirou Yasunaga, Masao Matsuoka, Yves Pommier,
Shunichi Takeda, Akifumi Takaori-Kondo. (2023) HTLV-1 b IP factor impairs DNA mismatch
repair system. Biochemical and biophysical research communications, 657, :43-49, 20230321(doi.org/10.1016/j.bbrc.2023.03.049)
11. Tamas Nemeth, Naoko Yoshizawa-Sugata, Agnes Pallier, Youichi Tajima, va T th, Hisao
Masai, and Yoko Yamakoshi (2023)

ater-Soluble Gd(III)-Porphyrin Complexes Capable ofBoth Photosensitization and Relaxation Enhancement. Chemical & Biomedical Imaging
12 1(2):157-167. (doi: 10.1021/cbmi.3c00007)
12. Karin Hori, Satoshi Yamazaki, Chiaki Ohtaka-Maruyama, Tomio Ono, Tomohiro Iguchi, andHisao Masai (2023) Cdc7 kinase is required for postnatal brain development. Genes Cellsdoi:

10.1111/gtc.13059.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 4 ௳㸧

Masai, H. (2022) TT-pocket/HIRAN: binding to 3 -terminus of DNA for recognition andprocessing of stalled replication forks. J. Biochem. 172(2):57-60. (doi: 10.1093/jb/mvac042)2.

ṇ஭ஂ㞝 (2022) ࢤࣀ࣒࡟₯ࡴᮍゎ᫂ࡢࢩࢢࢼࣝ㸪ࢢ࢔ࢽࣥ 4 㔜㙐 ᐇ㦂་Ꮫ ቑหྕ ࠗࢭࣥࢺࣛࣝࢻ
ࢢ࣐ࡢ᪂ᖖ㆑࠘Vol.40-No.12 66-76.⨺ᅵ♫ (ᰝㄞ᭷)3.

Masai, H. (2022) Replicon hypothesis revisited Biochemical and Biophysical ResearchCommunications 633:77-80. (doi: 10.1016/j.bbrc.2022.09.060)

4.

஭ཱྀ ᬛᘯࠊṇ஭ ஂ㞝 (2022) ࢢ࢔ࢽࣥ 4 㔜㙐ࡢᙧᡂ࡜」〇࡟࠾ࡅࡿᙺ๭࡜ ⏕≀Ꮫⓗព⩏ᮾி⌮⛉኱Ꮫ ⛉Ꮫࣇ࢛࣮࣒ࣛ ➨ 432 ྕ 4-7 ࣮࣌ࢪ－ 1－

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 10 ௳㸧
1.

➲἟ ༤அࠕDNA ௦ㅰࡢᇶ┙࡜࡞ࡿ⣽⬊᰾ᵓ㐀ࡢ᫬✵㛫ⓗゎᯒࠖ2022 ᖺ7 ᭶4 ᪥ 5 ᪥ ᰁⰍయᏳᐃ⥔ᣢ◊✲఍ࠊᅜ❧㑇ఏᏛ◊✲ᡤࠊ㟼ᒸࠊᣍᚅㅮ₇2.

➲἟ ༤அࠊ௚4 ྡࠕDDIAS promotes homologous recombination via control of Rad51 recombinaseࠖ(࢜ࣥࣛ࢖ࣥཧຍ) 2022 ᖺ9 ᭶14 ᪥ 16 ᪥ࠊ➨94 ᅇ᪥ᮏ㑇ఏᏛ఍ࠊᮐᖠࠊᣍᚅㅮ₇3.

➲἟ ༤அࠊ௚4 ྡࠕA role of DDIAS in homologous recombination࣮ࠖ࣡ࢡࢩࣙࢵࣉࠕྂࡃ࡚᪂ࡋ࠸DNA
㙐ษ᩿ಟ᚟ࡢ⌮ゎࢆ┠ᣦࡋ࡚ࠖ2022 ᖺ9 ᭶15 ᪥ࠥ17 ᪥ࠊᨺᑕ⥺ᙳ㡪Ꮫ఍ࠊ኱㜰ࠊᣍᚅㅮ₇

4.

Hiroyuki Sasanuma BRCA1 promotes repair of estrogen-induced and topoisomerase II-dependent DNA doublestrand breaks ࢩ࣏ࣥࢪ࣒࢘ࠕ㑇ఏᛶங⒴ࡢᇶ♏ࡢ⮫ᗋࠖࠊ➨81 ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ ࠊ2022 ᖺ9 ᭶31
᪥ 10 ᭶1 ᪥ࠊࣃࢩࣇ࢕ࢥᶓ὾ࠊᶓ὾ࠊᣍᚅㅮ₇

5.

Hisao Masai, ௚7 ྡ Regulation of replication timing and DNA repair by nuclear membrane tethering of Rif1 2022
INTERNATIONAL IBS CONFERENCE FOR GENOMIC INTEGRITY (October 18-20, 2022) Grand Josun
Hotel, Haeundae, Busan, South Korea, ᣍᚅㅮ₇

6.

Hisao Masai, ௚3 ྡ Transcription can drive replication 㑇ఏ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࠕ᪂᫬௦ࡢᰁⰍయ」〇◊✲㸸ྂࡃ࡚᪂ࡋ࠸⏕࿨⛉Ꮫࡢၥ㢟ࠖ2022 ᖺ11 ᭶í ᪥ ᅜ❧㑇ఏ◊ࠊ୕ᓥࠊᣍᚅㅮ₇7.

ṇ஭ ஂ㞝ࠊ௚6 ྡࠕ᰾㓟-ࢱࣥࣃࢡ㉁-ࣜࣥ⬡㉁┦஫స⏝ࢆ௓ࡋࡓᰁⰍయ㧗ḟᵓ㐀ࡢᙧᡂࠖ➨95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ࢩ࣏ࣥࢪ࣒࢘ࠊ2022 ᖺ11 ᭶11 ᪥ࠊྡྂᒇᅜ㝿఍㆟ሙࠊྡྂᒇࠊᣍᚅㅮ₇8.

ṇ஭ ஂ㞝ࠊ௚3 ྡ

RNA-DNA hybrid driven formation of G-quadruplex promotes an alternative mode of the

Escherichia coli chromosome replication ࠊ ➨45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2022 ᖺ11 ᭶30 12 ᭶2 ᪥ ᖥᙇ࣓ࢵࢭࠊ༓ⴥࠊᣍᚅㅮ₇9.

➲἟ ༤அࠊ௚1 ྡ ࣮࣡ࢡࢩࣙࢵࣉࠕDNA ಟ᚟ࡢ⌮ゎ / Understanding of DNA damage repairs ศᏊ࠿ࡽಶ
య࡬㸸DNA ᦆയಟ᚟ᶵᵓࡢໟᣓⓗ⌮ゎࢆ┠ᣦࡋ࡚ࠖࠊ➨45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2022 ᖺ11 ᭶
30 12 ᭶2 ᪥ ᖥᙇ࣓ࢵࢭࠊ༓ⴥࠊᣍᚅㅮ₇

10. Hisao Masai, ௚7 ྡ Regulation of replication timing and DNA repair by nuclear membrane tethering of Rif1 13th
isDDRHD (Dec. 9-11th, 2022) Shenzhen, China, ᣍᚅㅮ₇ࡑࡢ௚ 㸦ィ 18 ௳㸧⮬⏤ᥖ㍕－－

࠙ᅜෆ◊✲఍ࠊᏛ఍࡞࡝㸸ཱྀ㢌Ⓨ⾲࠾ࡼࡧ࣏ࢫࢱ࣮ࠚ
1.

➲἟༤அࠊᒣ⏣⯟ୡࠊ⣽㔝┿⏤ࠊṇ஭ஂ㞝, 㐟బᏹ௓recombination via control of Rad51 recombinase.

DDIAS promotes homologous᪥ᮏ㑇ఏᏛ఍➨ 94 ᅇ኱఍ 2022/9/14㹼

2022/9/17 ࢜ࣥࣛ࢖ࣥ
2.

➲἟༤அࠊᒣ⏣⯟ୡࠊ⣽㔝┿⏤ࠊ㐟బᏹ௓a role of DDIAS in homologous recombination

ࠗBRCA2 ࡜ྜᡂ⮴Ṛᛶࢆࡋࡵࡍ DDIAS 㑇ఏᏊࡣࠊ┦ྠ⤌᥮࠼࡟㔜せ࡞ᙺ๭ࢆᯝࡓࡍ࠘
᪥ᮏᨺᑕ⥺ᙳ㡪Ꮫ఍➨ 65 ᅇ኱఍ 2022/9/14㹼2022/9/17 ኱㜰බ❧኱Ꮫᮡᮏ࢟ࣕࣥࣃࢫ/኱
㜰ᕷ
3.

➲἟༤அ

ࠗBRCA1 ࡣࠊ࢚ࢫࢺࣟࢤࣥ࡟ࡼࡗ࡚ㄏᑟࡉࢀࡿࢺ࣏࢖ࢯ࣓࣮ࣛࢮ 2 ᆺ㓝⣲࡟ࡼࡿ DNA ஧༑㙐ษ᩿ࡢಟ᚟ࢆಁ㐍ࡍࡿ࠘➨ 81 ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡㞟఍ 2022/9/29㹼
2022/10/1 ࣃࢩࣇ࢕ࢥᶓ὾/⚄ዉᕝ┴ᶓ὾ᕷ4.

ṇ஭ஂ㞝,ࠊ஭ཱྀᬛᘯࠊఀ⸨ࡉࡺࡾࠊぬṇ┤Ꮚࠊ῝ὠ⌮஀ࠊ᳃ᒣ㈼἞ࠊ➲἟༤அ ࠗ᰾㓟ࢱࣥࣃࢡ㉁-ࣜࣥ⬡㉁┦஫స⏝ࢆ௓ࡋࡓᰁⰍయ㧗ḟᵓ㐀ࡢᙧᡂ࠘ ➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ኱఍
2022/11/9㹼2022/11/11 ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ5.

hiying You, Chi-Chun Yang, Hisao Masai Regulation of DNA replication fork activity by
Claspin phosphorylation and intramolecular interaction㑇ఏ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ 2022

2022/11/11㹼2022/11/12 ᅜ❧㑇ఏᏛ◊✲ᡤ/㟼ᒸ┴୕ᓥᕷ
6.

ᇼ࠿ࡾࢇ, Tomohiro Iguchi, Satoshi Yamazaki, Hisao Masai Roles of Cdc7 Kinase Complex in
Brain Development㑇ఏ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ 2022 2022/11/11㹼2022/11/12 ᅜ❧㑇ఏᏛ◊✲ᡤ/㟼ᒸ┴୕ᓥᕷ7.

Hao- en Hsiao

Differential roles of Claspin in DNA replication, checkpoint signaling, andfunction in cancer cells and in CD4 T cells.

㑇ఏ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ 2022 2022/11/11㹼

2022/11/12 ᅜ❧㑇ఏᏛ◊✲ᡤ/㟼ᒸ┴୕ᓥᕷ8.

ṇ஭ஂ㞝ࠊ∦ᒣຮ DNA 」〇ࢩࢫࢸ࣒ ࠗከᵝ࡞」〇ࢩࢫࢸ࣒࡟ࡼࡿ⎔ቃኚືᑐᛂࡢ࣓
࢝ࢽࢬ࣒࠘➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ ࣮࢜࢞ࢼ࢖ࢨ࣮ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵ

ࢭ/༓ⴥ┴
9.

Hiroyuki Sasanuma ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵࣉ ࣮࢜࢞ࢼ࢖ࢨ࣮
2022 ᖺ 11 ᭶ 30 12 ᭶ 2 ᪥ᖥᙇ࣓ࢵࢭࠊ༓ⴥ

10. ⏣୰༟, 㮛᭸Ꮚ, ῝ὠ⌮஀, ṇ஭ஂ㞝 ࠗMulti-replicon ᵝᘧࡢ኱⭠⳦ᰁⰍయ」〇ࡣ㌿෗࡟క࠺ G4 ᙧᡂ࡟౫Ꮡࡍࡿ࠘➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴
11. ຍ⣡㇏, ᯇᮏΎ἞, ୖ㔝຾, ṇ஭ஂ㞝 ࠗRif1 ࡢ㐣๫Ⓨ⌧ࡣᰁⰍయࢆ෌㓄⨨ࡋᰁⰍయศ㓄ࢆ㜼ᐖࡍࡿ࠘ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴－－12. 㧗஭⿱Ꮚ, ᳿඼㥴, ṇ஭ஂ㞝 ࠗClaspin ࡢࣜࣥ㓟໬࡜ศᏊෆ┦஫స⏝࡟ࡼࡿ」〇ࣇ࢛࣮ࢡ」ྜయࡢάᛶไᚚ࠘ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ
┴13. ⏣ᓥ㝧୍ Cell fusion upregulates PD-L1 expression and promotes tumor formation.

➨ 45 ᅇ

᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴14. ஭ཱྀᬛᘯ, ᒣᓮ⪽ᚿ, ᑠ㔝ᐩ⏨, ▼஭㔛⤮, ᇼ࠿ࡾࢇ, ᑠᯘ㥴㍜, ➲἟༤அ, ṇ஭ஂ㞝
ࠗCdc7 ࠾ࡼࡧ ASK㸦Dbf4㸧Ḟᦆ࣐࢘ࢫࡣඹ㏻࠿ࡘ␗࡞ࡿ⾲⌧ᆺࢆ♧ࡍ࠘ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴ࠊཱྀ㢌Ⓨ⾲
15. 㮛᭸Ꮚ, ⏣୰༟, ຍ⣡㇏,ṇ஭ஂ㞝 ࠗศ⿣㓝ẕ࣭኱⭠⳦࡟࠾ࡅࡿ RNA-DNA hybrid ࡢ⣽⬊ෆ࡛ࡢᏑᅾᵝᘧࡢゎᯒ࠘➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴
16. ᳿඼㥴ࠊⷜⓡᩥࠊṇ஭ஂ㞝ࠗከᵝ࡞⏕యࢫࢺࣞࢫ཯ᛂ࡟࠾ࡅࡿ」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺ࣓
ࢹ࢕࢚࣮ࢱ࣮Claspin ࡢ᪂つᶵ⬟ࡢゎ᫂࠘ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼
2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴17. ᮡᒣ ൉ࠊ௚8 ྡ, ṇ஭ ஂ㞝, ๓⃝ ๰

Dynamic nuclear lamina-chromatin interactions during spermatogenesis

2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴ࠊཱྀ㢌Ⓨ⾲
18. Hisao Masai , Chi-Chun Yang, Hao- en Hsiao , hiying You Novel roles of Claspin in cellularresponses to biological stresses.

AT 2023 2023/3/2㹼2023/3/5 ி㒔ᗓ❧ி㒔Ꮫ࣭Ṕᙬ㤋/ி㒔ᕷࠊ(ཱྀ㢌Ⓨ⾲)III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 2 ௳㸧࠙᪂Ꮫ⾡㡿ᇦ 㡿ᇦ఍㆟ࠚ
1.

ṇ஭ஂ㞝ࠗࢢ࢔ࢽࣥ㸲㔜㙐ࢆ௓ࡋ࡚᰾⭷㏆ഐ࡟ᙧᡂࡉࢀࡿࢡ࣐ࣟࢳࣥࢻ࣓࢖ࣥ࡟ࡼࡿᰁ
Ⰽయືែไᚚ࠘ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢡ࣐ࣟࢳࣥ₯ᅾ⬟ࠖ➨ 2 ᅇ㡿ᇦ఍㆟ࠊ2022 ᖺ 5 ᭶ 25 27 ᪥ࠊᒸᓮࢥࣥࣇ࢓ࣞࢫࢭࣥࢱ࣮ࠊឡ▱2.

ṇ஭ஂ㞝࢚ࠗࣆࢤࣀ࣒᝟ሗ࡜ࡋ࡚ࡢࢢ࢔ࢽࣥ㸲㔜㙐ࡢᙧᡂ࡜」〇㛤ጞ࡟࠾ࡅࡿᙺ๭࡜⏕≀Ꮫⓗព⩏࠘ ᪂Ꮫ⾡㡿ᇦ ࠕ㠀ࢤࣀ࣒᝟ሗ」〇ࠖ➨ 5 ᅇ 㡿ᇦ఍㆟ࠊࢩ࣮ࢧ࢖ࢻ࣍ࢸࣝ⯙Ꮚࣅࣛ⚄ᡞࠊ2022 ᖺ 8 ᭶ 1 3 ᪥ (hybrid)－－IV. ≉グ஦㡯࠙኱Ꮫㅮ⩏ࠚ
1. ṇ஭ ஂ㞝ࠊ஭ཱྀ ᬛᘯࠊ➲἟ ༤அ ᮾி⌮⛉኱Ꮫ ⌮ᕤᏛ㒊㸪ᛂ⏝⏕≀⛉Ꮫ⛉  ᖺᗘ⏕≀⛉Ꮫ≉ูㅮ⩏㸦ᑐ㠃ᤵᴗ㸧ࠕࢤࣀ࣒ࡢ⥅ᢎ࣭⥔ᣢ࣭ᶵ⬟Ⓨ⌧ࡢ᪂ཎ⌮ࡢゎ᫂ࢆ┠ᣦࡋ࡚ࠖ ᖺ ᭶ ᪥ࠊ ᭶ ᪥
2.

➲἟ ༤அࠕࡀࢇ⏕≀Ꮫࠊ'1$ ᦆയಟ᚟ᶵᵓ࡜ࡑࡢ◚⥢࡟ࡼࡿ⑓ែࠖᮾி⌮⛉኱Ꮫ ⌮ᕤᏛ㒊㸪ᛂ⏝⏕≀⛉Ꮫ⛉ࠊ⏕≀⛉Ꮫ≉ูㅮ⩏ࠊ ᖺ ᭶ ᪥

3. ṇ஭ ஂ㞝 ᮾி኱Ꮫ ⌮Ꮫ㒊 ⏕≀໬Ꮫ⛉ࠊ ᖺᗘ ⣽⬊ศᏊ⏕≀Ꮫࠊᮾ኱⌮Ꮫ㒊⏕≀⛉Ꮫ⛉ㅮ⩏ᐊ㸦ᑐ㠃ᤵᴗ㸧 ᖺ ᭶ ᪥ࠊ ᭶ ᪥
4. ➲἟ ༤அࠕ⑓⌮Ꮫ⥲ㄽ࣭ᨺᑕ⥺⏕≀Ꮫࠊᨺᑕ⥺ࠊ⣸እ⥺ࠊᢠࡀࢇ๣࡟ࡼࡿ'1$ ᦆയಟ᚟ࠖࠊி㒔኱Ꮫ ་Ꮫ㒊  ᖺ ᭶ ᪥
5. ➲἟ ༤அࠕ⑓⌮Ꮫ⥲ㄽ࣭ᨺᑕ⥺⏕≀Ꮫࠊᨺᑕ⥺⿕᭚ࡢ඲㌟࡬ࡢᙳ㡪ࠖࠊி㒔኱Ꮫ ་Ꮫ㒊  ᖺ ᭶᪥
6. ṇ஭ ஂ㞝 ஑ᕞ኱Ꮫ ⸆Ꮫ⣔◊✲⛉ ㅮ⩏ 㸦ᑐ㠃ᤵᴗ㸧ࠕᰁⰍయ⏕≀Ꮫ࡜ࡑࡢ⒴◊✲࡬ࡢᛂ⏝ࠖ ᖺ᭶ ᪥
7. ṇ஭ஂ㞝 ᮾி኱Ꮫ ᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉  ᖺᗘ Ⓨᒎㅮ⩏,9㸦=RRP㸧 ࠕࢤࣀ࣒」〇ไᚚࢆ௓ࡋࡓࢤ
ࣀ࣒Ᏻᐃᛶ⥔ᣢࡢศᏊᶵᵓ࡜ࡑࡢ◚⥢࡟ࡼࡿ⑌ᝈࡢⓎ⏕ࠖ ᖺ ᭶ ᪥
8. ṇ஭ஂ㞝 ᪥ᮏ኱Ꮫᩥ⌮Ꮫ㒊 ◊✲ᡤゼၥ 㸦=RRP㸧 ᖺ ᭶ ᪥
9. ➲἟ ༤அࠊ஭ཱྀ ᬛᘯࠊṇ஭ ஂ㞝 ᐑᇛ┴௝ྎ➨஧㧗➼Ꮫᰯ ◊✲ᡤゼၥ  ᖺ ᭶ ᪥
10. ṇ஭ ஂ㞝 ᮾி㎰኱ ࣂ࢖࢜ࢧ࢖࢚ࣥࢫᑓᨷࠕศᏊ⣽⬊⏕≀Ꮫࠖ㸦ᑐ㠃ᤵᴗ㸧ࠕࢤࣀ࣒࡟Ꮡᅾࡍࡿࠊኚࢃࡗ
ࡓᙧࢆࡋࡓ'1$ ࡜ࠊࡑࡢ'1$ 」〇ไᚚ࡟࠾ࡅࡿᙺ๭ࠖ ᖺ ᭶ ᪥－ 5－ࣉࣟࢪ࢙ࢡࢺྡ

㞴⫈ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou,Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie
Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino, Toyoyuki Takada, Toshihiko Shiroishi, Ryo
Kominami, Yoshiaki Kikkawa. Two Loci Contribute to Age-Related Hearing Loss Resistance in
the Japanese Wild-Derived Inbred MSM/Ms Mice Biomedicines., 10,9: 2221, 20220907.
(doi.org/10.3390/biomedicines10092221)

2.

Ikuo Miura, Yoshiaki Kikkawa, Shumpei P. Yasuda, Akiko Shinogi, Daiki Usuda, Vivek Kumar,
Joseph S. Takahashi, Masaru Tamura, Hiroshi Masuya, Shigeharu Wakana Characterization ofSingle Nucleotide Polymorphisms for a Forward Genetics Approach using Genetic Crosses in
C57BL/6 and BALB/c Substrains of Mice Experimental Animals, 71,2: 240-251 20220520. (doi:10.1538/expanim.21-0181)

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1. 㛵 ඃኴࠊྜྷᕝḠு㸸㞴⫈ࡢ㑇ఏⓗせᅉ࡜Ⓨ⑕࣓࢝ࢽࢬ࣒ ་Ꮫࡢ࠶ࡺࡳ㸪282, 648-656,
2022.
2. ྜྷᕝḠு㸪㛵 ඃኴ㸪Ᏻ⏣ಇᖹ㸸࣑࢜ࢩࣥVIࣁࣉࣟ୙඲࡟㉳ᅉࡍࡿຍ㱋ᛶ㞴⫈㸬ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ࡜࢖ࣥࢲࢫࢺ࣮ࣜ㸪80, 301-305, 2022.
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕

－ 6－

1.

Yoshiaki Kikkawa, Shumpei P. Yasuda, Ai Takahashi, Ting Mao, Ornjira Prakhongcheep, Yuta
Seki, Hiroshi Shitara, Kunie Matsuoka: Functional Analysis of Downregulated Genes afterSpecific Depletion of Outer Hair Cells in mice. 36th International Mammalian Genome
Conference. 20230328-20230331, Tsukuba, Japan ࣏ࢫࢱ࣮Ⓨ⾲

2.

Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou, Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie
Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino, Toyoyuki Takada, Toshihiko Shiroishi, Ryo
Kominami, Yoshiaki Kikkawa: Two loci, ahl3 and ahl10, Contribute to Age-Related Hearing Loss
Resistance in Japanese Wild-derived Inbred MSM/Ms Mice. 36th International Mammalian
Genome Conference. 20230328-20230331, Tsukuba, Japan ࣏ࢫࢱ࣮Ⓨ⾲

3.

Yuta Seki, Hiroshi Shitara, Rie Ishii, Takafumi Ouchi, Shumpei P. Yasuda, Yoshiaki Kikkawa:
Myosin VI Haploinsufficiency Reduced Hearing Ability in Mice. 36th International Mammalian
Genome Conference. 20230328-20230331, Tsukuba, Japan ࣏ࢫࢱ࣮Ⓨ⾲

4.

Xuehan Hou, Shumpei P. Yasuda, Ting Mao, Ornjira Prakhongcheep, Yoshiaki Kikkawa:
Cadherin 23 Genotypes are Associated with Differences in Recovery from Hearing Loss Due toNoise Trauma in Mice. 36th International Mammalian Genome Conference. 20230328-20230331,
Tsukuba, Japan ཱྀ㢌࠾ࡼࡧ࣏ࢫࢱ࣮Ⓨ⾲

5.

Ᏻ⏣ಇᖹ㸪ᐑᆏຬ㍤㸪౳ 㞷ྵ㸪ᑠཎ ኸ㸪タᴦᾈᚿ㸪㛵 ඃኴ㸪ᯇᒸ㑥ᯞ㸪㧘ᶫ࠶࠸㸪ⱝ஭ᜨ㔛㸪᪥ẚ㔝ᾈ㸪㧗⏣㇏⾜㸪ᇛ▼ಇᙪ㸪ᮌ༡ ෽㸪ྜྷᕝḠு㸸ahl3 ࠾ࡼࡧ ahl10
㑇ఏᏊᗙࡣ᪥ᮏ⏘㔝⏕࣐࢘ࢫ⏤᮶ MSM ⣔⤫ࡢຍ㱋ᛶ㞴⫈᢬ᢠᛶ࡟㛵୚ࡍࡿ㸬᪥ᮏ㑇ఏᏛ఍➨ 94 ᅇ኱఍㸬20220914-20220916, ໭ᾏ㐨኱ᏛᕤᏛ㒊, ໭ᾏ㐨ᮐᖠᕷ ཱྀ㢌Ⓨ⾲6.

Ᏻ⏣ಇᖹ㸪㛵 ඃኴ㸪౳ 㞷ྵ㸪㧗⏣㇏⾜㸪ᇛ▼ಇᙪ㸪ྜྷᕝḠு㸸MSM/Ms ࣐࢘ࢫࡢahl10 㑇ఏᏊᗙࡢຍ㱋ᛶ㞴⫈Ⓨ⑕ᢚไຠᯝࡢ᳨ド㸬➨ 69 ᅇ ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍
20220518-20220520 ௝ྎᅜ㝿ࢭࣥࢱ࣮, ᐑᇛ┴௝ྎᕷ ࣏ࢫࢱ࣮Ⓨ⾲

7.

㛵 ඃኴࠊタᴦᾈᚿࠊ▼஭㔛⤮ࠊ኱ෆᓫྐࠊᏳ⏣ಇᖹࠊྜྷᕝ Ḡு ࣑࢜ࢩࣥუࡢࣁࣉࣟ୙
඲ࡣ࣐࢘ࢫࡢ⫈ຊపୗࢆࡶࡓࡽࡍ ➨ 69 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 20220518-20220520
௝ྎᅜ㝿ࢭࣥࢱ࣮ ᐑᇛ┴௝ྎᕷ ࣏ࢫࢱ࣮Ⓨ⾲

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯－ 7－ࣉࣟࢪ࢙ࢡࢺྡ

࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

BBA Mol Cell Res 1869 (2022) 119188.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 1 ௳㸧ࠕ㞴⑓࡜ᅾᏯࢣ࢔ࠖ1 (2023) 14-18.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

㔝ཱྀ࠶ࡸࠊ⛙຾ᚿࠊᅵᒇගࠊタᴦᾈᚿࠊ⏣୰ၨ஧ࠊబ఑Ὀࠊᑠ㔝ᘺᏊ㸸ࣘࣅ࢟ࢳࣥ㸫࢝ࣝࣃ࢖ࣥ⣔࡟ࡼࡿ⣽⬊᥋╔ไᚚ㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍㸦ࢩ࣏ࣥࢪ࣒࢘㸸⣽⬊ෆࢩࢢࢼࣝࡢ㛤ጞ࣭⥅⥆࣭⤊↉࡟ാࡃከᵝ࡞ࢱࣥࣃࢡ㉁ศゎᶵᵓ㸪2022.11.11㸧

ࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕
1.

኱ෆྐᏊࠊᅵ஭ዉ✑Ꮚࠊ୕ୖᜤᖹࠊ஭ཱྀ⩏ಙࠊ⛙຾ᚿࠊᑠ㔝ᘺᏊ㸸⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕
࣮㹐㸯ᆺࣔࢹ࣐ࣝ࢘ࢫࡢ⫢⮚࡟࠾ࡅࡿ⬡㉁⵳✚ᢚไ㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍
㸦2022.11.9ࠊ
ཬࡧ 2022.11.10(ཱྀ㢌)㸧

2.

⛙຾ᚿࠊ㔝ཱྀ࠶ࡸࠊᅵᒇගࠊᾏಖឡࠊタᴦᾈᚿࠊ⏣୰ၨ஧ࠊబ఑Ὀࠊᑠ㔝ᘺᏊ㸸CAPN15ࡣࣘࣅ࢟ࢳࣥ໬ࢱࣥࣃࢡ㉁ࢆᶆⓗ࡜ࡍࡿ࢝ࣝࣃ࢖࡛ࣥ࠶ࡾ⣽⬊᥋╔ࢆไᚚࡍࡿ㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍㸦2022.11.10㸧

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧
࡞ࡋ

－

－

IV. ≉グ஦㡯
ᑠ㔝ᘺᏊ
1.

ᩍ⫱άື
࣭⡿࣭࢔ࣜࢰࢼ኱Ꮫ⣽⬊ศᏊ་Ꮫ◊✲⛉ᐈဨ≉௵ㅮᖌ࣭⟃Ἴ኱Ꮫ኱Ꮫ㝔㐃ᦠᩍဨࠊ࠾ⲔࡢỈዪᏊ኱Ꮫ኱Ꮫ㝔㐃ᦠᩍဨ

2.

Ꮫ⾡άື
࣭Journal of General Physiology ⦅㞟ጤဨ
࣭BBA Molecular Cell Research ⦅㞟ጤဨ࣭᪥ᮏ⑓ែࣉࣟࢸ࢔࣮ࢮᏛ఍ホ㆟ဨ

3.

♫఍άື
࣭ື≀⏝⤌ࡳ᥮࠼ DNA ᢏ⾡ᛂ⏝་⸆ရㄪᰝ఍ ⸆஦࣭㣗ရ⾨⏕ᑂ㆟఍ᑓ㛛ጤဨ࣭ື≀⏝෌⏕་⒪➼〇ရ࣭ࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮ᛂ⏝་⸆ရㄪᰝ఍ጤဨ
࣭ᅜ㝿⏕≀Ꮫ࢜ࣜࣥࣆࢵࢡ᪥ᮏጤဨ఍㐠Ⴀጤဨ࣭స㢟ጤဨ－－ࣉࣟࢪ࢙ࢡࢺྡ

ᖿ⣽⬊ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 3 ௳㸧
1.

K. Kitajima, M. Shingai, H. Ando, M. Hamasaki, and T. Hara. An interferon-Ȗ)/7D[LV
SRVLWLYHO\UHJXODWHVKHPRSRLHWLFSURJHQLWRUFHOOH[SDQVLRQIURPKXPDQSOXULSRWHQWVWHPFHOOVStem Cells, 40: 906-918, 2022. (GRLRUJVWPFOVV[DF (ᰝㄞ᭷2.

K. Tsujihana , K. Tanegashima , Y. Santo, H. Yamada, S. Akazawa, R. Nakao, K. Tominaga, R.
Saito, Y. Nishito, R. Hata, T. Nakamura, I. Murai, Y. Kono, M. Sugawa, M. Tanioka, G. Egawa,
M. Doi, T. Isa, K. Kabashima, T. Hara , and H. Okamura . Circadian protection against bacterial
skin infection by HSLGHUPDO&;&/-mediated innate immunity. Proc. Natl. Acad. Sci. U.S.A.,
119: e2116027119, 2022. (GRLRUJSQDV  Equally contributed authors.
Co-corresponding authors. (ᰝㄞ᭷

K. Yamazaki, K. Matsuo, A. Okada, N. Uno, T. Suzuki, S. Abe, S. Hamamichi, N. Kishima, S.
Togai, K. Tomizuka, and Y. Kazuki. Simultaneous loading of PCR-based multiple fragments on
mouse artificial chromosome vectors in DT40 cell for gene delivery. Sci. Rep., 12: 21790-21790,
2022. GRLRUJV-022-- (ᰝㄞ᭷ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

ཎ㸦ィ 1 ௳㸧Ꮥᙪ㸸࣐࢘ࢫఇ╀ᮇࡢ⓶⭵࡛ാࡃᢠ⳦ච␿ࢩࢫࢸ࣒. Bioscience & Industry, 81: 28-29,

20.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 9 ௳㸧⮬⏤ᥖ㍕

－

－

1.

ᩪ⸨⌮బ, ✀Ꮚᓥᖾ♸, ཎ Ꮥᙪ. Innate immune responses triggered by CpG DNA-&;&/
FRPSOH[LVPHGLDWHGE\,PPXQRJOREOLQVXSHUIDPLO\SURWHLQV 㸦ཱྀ㢌Ⓨ⾲㸧➨  ᅇ᪥ᮏච␿Ꮫ
఍Ꮫ⾡㞟఍, 2022.12.7-9, ⇃ᮏ.

2.

✀Ꮚᓥᖾ♸, ᩪ⸨⌮బ, ཎ Ꮥᙪ.ࢣࣔ࢝࢖ࣥ &;&/ ࡜ Ig superfamily ࢱࣥࣃࢡ࡟ࡼࡿ࢜
ࣜࢦࢹ࢜࢟ࢩࢾࢡࣞ࢜ࢳࢻࡢ⣽⬊ෆ㏦㐩ᶵᵓࡢゎᯒ.㸦ཱྀ㢌Ⓨ⾲㸧➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2022.-12.2, ᖥᙇ.

໭ᓥ೺஧, ┿㈅⨾ዉᏊ, Ᏻ⸨㍤, ཎ Ꮥᙪ)/7)/7/VLJQDOLQJDXJPHQWVWKHLQGXFWLRQRI
tumor-killing macrophages from human induced pluripotent stem cells.㸦ཱྀ㢌Ⓨ⾲㸧➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍-12.2, ᖥᙇ.

4.

ಖᒇ㔝⩧ኴ, 㛵ᩥဢ, ୰⏣༓ᑜ, ඵᮌᣅဢ, す⸨Ὀᫀ, ᮾᬛஓ, ໭⏣᪼㞝, ∾ᫀḟ㑻, ཎ Ꮥ
ᙪ. ᛴᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࢆ≉␗ⓗ࡟Ṛ⁛ࡉࡏࡿ໬ྜ≀ࡢస⏝ᶵᗎ. ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍-12.2, ᖥᙇ.

┿㈅⨾ዉᏊ, ໭ᓥ೺஧, Ᏻ⸨㍤, ὾ᓮ┿Ꮚ, ཎ Ꮥᙪ. Analysis of differentiation process fromhuman induced pluripotent stem cells to hematopoietic cells using a new in vitro differentiationinduction method. ➨ 4 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍-12.2, ᖥᙇ.

6.

బࠎᮌ⣸ಖ, 㕥ᮌ㍤ᙪ, ᒣᕝ┿ዉ, ᐑᮏே୸, Ᏹ㔝ឡᾏ, 㤶᭶ᗣᏹ, ཎ Ꮥᙪ. ᰁⰍయᕤᏛ
ᢏ⾡ᛂ⏝㸦㸱㸧
㸸࣐࢘ࢫ ES ⣽⬊ࢆᰁⰍయ౪୚⣽⬊࡜ࡋࡓᰁⰍయᑟධᢏ⾡ࡢ㛤Ⓨ. ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍-12.2, ᖥᙇ.

7.

⣽㇂ ᭸㍤, ᮾ ᬛஓ, ಖᒇ㔝 ⩧ኴ, 㛵 ᩥဢ, ໭⏣ ᪼㞝, ᖹ㔝 ㄃, ཎ Ꮥᙪ, ∾ ᫀḟ㑻.
ᢠ T ⣽⬊ᛶᛴᛶࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓άᛶࢆ᭷ࡍࡿ໬ྜ≀ࡢ⨨᥮ᇶ R ಟ㣭㒊఩ࡢ᥈⣴. ➨ ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍-12.2, ᖥᙇ.

8.

ಖᒇ㔝⩧ኴ, 㛵ᩥဢ, ୰⏣༓ᑜ, ඵᮌᣅဢ, す⸨Ὀᫀ, ᮾᬛஓ, ∾ᫀḟ㑻, ཎ Ꮥᙪ. ᛴᛶ Tࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࢆ≉␗ⓗ࡟Ṛ⁛ࡉࡏࡿ໬ྜ≀ࡢస⏝ᶵᗎ. ᮾி㒔❧኱Ꮫࣂ࢖࢜
࢝ࣥࣇ࢓ࣞࣥࢫ, 2022.11.11, ༡኱ἑ.

9.

໭ᓥ೺஧, ┿㈅⨾ዉᏊ, Ᏻ⸨㍤, ཎᏕᙪ An interferon-Ȗ)/7$[LVSRVLWLYHO\UHJXODWHVKHPRSRLHWLFSURJHQLWRUFHOOH[SDQVLRQIURPKXPDQSOXULSRWHQWVWHPFHOOV. ➨ 19 ᅇᖿ⣽⬊ࢩ࣏ࣥࢪ࣒࢘27-28, ῐ㊰ᓥ.

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧

－ 1－

IV. ≉グ஦㡯
1.

ཎ Ꮥᙪ. Frontiers in Cell Dev. Biol., Associate editor2.

ཎ Ꮥᙪ. ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔࣭་ṑᏛ⥲ྜ◊✲⛉ࠕ㒔་Ꮫ◊⑌ᝈศᏊ⏕≀Ꮫࠖ㐃ᦠᩍᤵ࣭ศ㔝㛗㸦኱Ꮫ㝔⏕ 7 ྡࢆᣦᑟ㸧.

.

ཎ Ꮥᙪ. ᮾி㒔❧኱Ꮫ኱Ꮫ㝔࣭⌮Ꮫ◊✲⛉⏕࿨⛉Ꮫᑓᨷࠕᖿ⣽⬊ไᚚᏛࠖ㐃ᦠᩍᤵ㸦኱Ꮫ㝔⏕ 1 ྡࢆᣦᑟ㸧.

4.

ཎ Ꮥᙪ. ୰ኸ኱Ꮫ⌮ᕤᏛ㒊 ㅮ⩏ࠕ࢚࢖ࢪࣥࢢ⏕≀Ꮫࠖ㸦⏕࿨⛉Ꮫ⛉࡞࡝  ᖺ⏕ 47 ྡ㸧
2022.4 7 ᭶ (ィ 14 ᅇ㸩ᮇᮎヨ㦂  ᚋᴦᅬ.

.

ཎ Ꮥᙪ. ᮾி㒔໭༊ࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࢫࢡ࣮ࣝ㸦୰㧗⏕ 21 ྡ㸧ࠕ་⒪࡜⏕࿨⛉Ꮫࡢୡ⏺
ࢆࡢࡒ࠸࡚ࡳࡼ࠺ࠖ2022.7.28, ࢜ࣥࣛ࢖ࣥ.

6.

㕥ᮌ㍤ᙪ, ཎ Ꮥᙪ. PCT ฟ㢪ࠕMHC 㑇ఏᏊ⩌ࣄࢺ໬ື≀ࠖ௧࿴  ᖺ  ᭶ 14 ᪥－－ࣉࣟࢪ࢙ࢡࢺྡ

⺮ⓑ㉁௦ㅰࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧

<RVKLQR$NL]XNL0DL0RULWD<XNL0RUL$L.DLKR6RPD6KLYDQL'L[LW$NLQRUL(QGR0DULH
6KLPRJDZD*RVXNH+D\DVKL0LNLKLNR1DLWR$NLPLWVX2NDPRWR.HLML7DQDND<DVXVKL6DHNL)XPLDNL2KWDNHF,$3EDVHGGHJUDGHUVLQGXFHGHJUDGDWLRQYLDEUDQFKHGXELTXLWLQDUFKLWHFWXUHV 
Nature Chemical Biology.,    GRLRUJV 

7VX\RVKL7DNDKDVKL7DWVX\D8FKLED\DVKL1R]RPL,VKLL,FKLUR0DWVXR<XNLNR<RVKLGD7DGDVKL6X]XNL/XPLQHVFHQFHGHWHFWLRQRISHSWLGH1JO\FDQDVHDFWLYLW\XVLQJHQJLQHHUHGVSOLWLQWHLQVChemical communications &DPEULGJH 
GRLRUJGFFH 



<RNR+DVHJDZD7KDLV+XDUDQFFD5H\HV7RPRKLUR8HPXUD$QLUEDQ%DUDO$NDUL)XMLPDNL <RQJPLQJ/XR<RVKLH0RULWD<DVXVKL6DHNL6KXJR0DHNDZD6KLJHWDND<DVXGD.RNL
0XNXWD<RLFKLUR)XNDR.HLML7DQDND$NLKLNR1DNDQR-XQSHL7DNDJL5LVKLNHVK3%KDOHUDR-XQML<DPDJXFKL7DNHR6DWR7KH7*1((61$5(SURWHLQ6<3DQGWKHXELTXLWLQOLJDVH
$7/FRRSHUDWLYHO\UHJXODWHSODQWUHVSRQVHVWRFDUERQQLWRURJHQFRQGLWLRQVLQ$UDELGRSVLV
Plant Cell   GRLSOFHOONRDF 

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.HQ]DEXUR<DPDML&RQJ7KDQK1JX\HQ<RVKLQRUL.LWDJDZD7DNDKLUR6DQDGD7RPRNR+RQGD7VXEDVD0XQDNDWD0DVDKLNR+LJD6DNLNR7R\DPD 5LVD.RQR $VDNR7DNDJL <XVXNH
0DWVXPRWR$\D.RVHNL .DRUL+D\DVKL 0DVDQRUL6KLRKDUD .RML,VKLL <DVXVKL6DHNL <DVKXVKL,WR 0LFKLQRUL.RKDUD$QDWWHQXDWHGYDFFLQLDYDFFLQHHQFRGLQJWKH6$56&R9VSLNHSURWHLQHOLFLWVEURDGDQGGXUDEOHLPPXQHUHVSRQVHVDQGSURWHFWVF\QRPROJXVPDFDTXHVDQGKXPDQ$&(WUDQVJHQLFPLFHIURP6$56&R9DQGLWVYDULDQWV Front Microbiol., 
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I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 31 ௳㸧
1.

Ying Li, Jian Dai, Fuyuki Kametani, Masahide Yazaki, Akihito Ishigami, Masayuki Mori, Hiroki
Miyahara, Keiichi Higuchi㸬Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of
Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging. The American journal ofpathology., 20230323. (doi.org/10.1016/j.ajpath.2023.03.002)

2.

Tomoaki Murakami, Toshisuke Kaku, Kaori Tsukakoshi, Susumu Iwaide, Yoshiyuki Itoh, Miki
Hisada, Kohji Nomura, Rikako Kubo, Kazunori Ikebukuro, Yukiko Sassa-O Brien, Fuyuki Kametani.
Identification of novel amyloidosis in dogs: Į-S1-casein acquires amyloidogenicity in mammary
tumor by overexpression and N-terminal truncation. Veterinary pathology., 20230121.
(doi.org/10.1177/03009858221148511)

3.

Hiroki Miyahara, Jian Dai, Ying Li, iaoran Cui, Hibiki Takeuchi, Naomi Hachiya, Fuyuki Kametani,
Masahide Yazaki, Masayuki Mori, Keiichi Higuchi. Macrophages in the reticuloendothelial system
inhibit early induction stages of mouse apolipoprotein A-II amyloidosis. Amyloid㸸the international
journal of experimental and clinical investigation: the official journal of the International Society of
Amyloidosis., 1-14, 20221210. (doi.org/10.1080/13506129.2022.2153667)

4.

Kyoko Kobayashi, Susumu Iwaide, Hiroki Sakai, Fuyuki Kametani, Tomoaki Murakami. Keratinic
amyloid deposition in canine hair follicle tumors. Veterinary Pathology., 20221011.
(doi.org/10.1177/03009858221128924)

5.

Fuyuki Kametani, Masato Hasegawa6WUXFWXUHVRIWDXDQGĮ-synuclein filaments from brains ofpatients with neurodegenerative diseases. Neurochemistry International., 158: 105362-105362,
202209. (doi.org/10.1016/j.neuint.2022.105362)

6.

Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko
Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo
Murayama, Hideki Mochizuki. Neuropathology of spinocerebellar ataxia type 8: Common features andunique tauopathy. Neuropathology., 20230126. (doi.org/10.1111/neup.12894)

7.

Goichi Beck, Rika Yamashita, Kansuke Kido, Kensuke Ikenaka, Tomoya Chiba, Yuki Yonenobu,
Yuko Saito, Eiichi Morii, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki. An autopsy case－ 7－

of progressive supranuclear palsy treated with monoclonal antibody against tau. Neuropathology.,
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8.

Peter T. Nelson, Edward B. Lee, Matthew D. Cykowski, Irina Alafuzoff, Konstantinos Arfanakis,
Johannes Attems, Carol Brayne, Maria M. Corrada, Brittany N. Dugger, Margaret E. Flanagan,
Bernardino Ghetti, Lea T. Grinberg, Murray Grossman, Michel J. Grothe, Glenda M. Halliday, Masato
Hasegawa, Suvi R. K. Hokkanen, Sally Hunter, Kurt Jellinger, Claudia H. Kawas,C. Dirk Keene,
Naomi Kouri, Gabor G. Kovacs, James B. Leverenz, Caitlin S. Latimer, Ian R. Mackenzie, inwen
Mao, Kirsty E. McAleese, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa
Myllykangas, Sukriti Nag, Janna H. Neltner, Kathy L. Newell, Robert A. Rissman, Yuko Saito, S.
Ahmad Sajjadi, Katherine E. Schwetye, Andrew F. Teich, Dietmar R. Thal, Sandra O. Tom , Juan C.
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Schneider, Dennis

ang, Charles L.

hite, Thomas

isniewski, Hyun-Sik Yang, Julie A.

. Dickson, Manuela Neumann. LATE-NC staging in routine neuropathologic

diagnosis: an update. Acta Neuropathologica., 20221213. (doi.org/10.1007/s00401-022-02524-2)
9.

Yang Yang, Yang Shi, Manuel Schweighauser, ianjun hang, Abhay Kotecha, Alexey G. Murzin,
Holly J. Garringer, Patrick. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T.

arner, Kazuko

Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa,Tammaryn Lashley, Sjors H.

. Scheres, MicheO*RHGHUW6WUXFWXUHVRIĮ-synuclein filaments fromhuman brains with Lewy pathology. Nature., 610, 7933: 791-795, 20221027.
(doi.org/10.1038/s41586-022-05319-3)
10. Sho Kaide, Hiroyuki

atanabe, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono. Synthesis and

Evaluation of 18F-/DEHOHG&KDOFRQH$QDORJXHIRU'HWHFWLRQRIĮ-Synuclein Aggregates in the Brain
Using the Mouse Model. ACS chemical neuroscience., 13, 20: 2982-2990,
20221019(doi.org/10.1021/acschemneuro.2c00473)
11. Yuki Suzuki, Tadashi Adachi, Mayuko Sakuwa, Ryoichi Sakata, Hiroshi Takigawa, Masato Hasegawa,Ritsuko Hanajima. An autopsy case of progressive supranuclear palsy. Pallidoဨnigroဨluysian type withargyrophilic grains clinically presenting with personality and behavioral changes. Neuropathology., 42,
5: 447 - 452, 202210. (doi.org/10.1111/neup.12815)
12. Ai Shimizu, Akio Akagi, Chiho Ishida, Kenji Sakai, Kiyonobu Komai, Mitsuru Kawamura, Masato

Hasegawa, Takeshi Ikeuchi, Masahito Yamada. Frontotemporal Lobar Degeneration with
Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy. Journal of Neuropathology
and Experimental Neurology., 81, 7: 581- 584, 20220620 (doi.org/10.1093/jnen/nlac039)
13. Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito,

Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama, Masato Hasegawa.
8OWUDVWUXFWXUDODQGELRFKHPLFDOFODVVLILFDWLRQRISDWKRJHQLFWDXĮ-synuclein and TDP-43. Acta
Neuropathologica., 143, 6: 613-640 (doi.org/10.1007/s00401-022-02426-3)
14. Yuya Kishino, Koji Matsukawa, Taisei Matsumoto, Ryota Miyazaki, Tomoko－－

akabayashi, Takashi

Nonaka, Fuyuki Kametani, Masato Hasegawa, Tadafumi Hashimoto, Takeshi Iwatsubo. Casein kinaseįİSKRVSKRU\ODWHVIXVHGLQVDUFRPD )86 DQGDPHOLRUDWHV)86-mediated neurodegeneration.
Journal of Biological Chemistry., 102191-102191, 202206 (doi.org/10.1016/j.jbc.2022.102191)
15. Takahiro Akasaka, Hiroyuki

atanabe, Sho Kaide, Shimpei Iikuni, Masato Hasegawa, Masahiro Ono.

6\QWKHVLVDQGHYDOXDWLRQRIQRYHOUDGLRLRGLQDWHGSKHQ\OEHQ]RIXUDQRQHGHULYDWLYHVDVĮ-synuclein
imaging probes. Bioorganic & Medicinal Chemistry Letters., 64, 128679-128679, 20220515(doi.org/10.1016/j.bmcl.2022.128679)
16. Rika Yamashita, Goichi Beck, Yuki Yonenobu, Kimiko Inoue, Akihiko Mitsutake, Hiroyuki Ishiura,

Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki. scp TDP /scp ဨ43 Proteinopathy
Presenting with Typical Symptoms of Parkinson s Disease. Movement Disorders.,
20220509(doi.org/10.1002/mds.29048)
17. Yuji Saitoh, Masaki Iwasaki, Masashi Mizutani, Yukio Kimura, Masato Hasegawa, Noriko Sato,

Masaki Takao, Yuji Takahashi. Pathologically Verified Corticobasal Degeneration Mimicking
Richardson s Syndrome Coexisting with Clinically and Radiologically ShuntဨResponsive Normal
Pressure Hydrocephalus. Movement Disorders Clinical Practice., 9, 4: 508-515, 202205.
(doi.org/10.1002/mdc3.13442)
18. Saitoh Y, Imabayashi E, Mizutani M, Tsukamoto T, Hasegawa M, Saito Y, Matsuda H, Takahashi

Y. 18F-THK5351 PET for visualizing predominant lesions of pathologically confirmed corticobasal
degeneration presenting with frontal behavioral-spatial syndrome. J Neurol. 2022
Sep 269(9):5157-5161. (doi: 10.1007/s00415-022-11121-y)
19. Hiroaki Miyahara, Akio Akagi, Yuichi Riku, Jun Sone, Yasushi Otsuka, Motoko Sakai, Satoshi Kuru,

Masato Hasegawa, Mari Yoshida, Akiyoshi Kakita, Yasushi Iwasaki. Independent distribution between
tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical
analysis in autopsy cases including cases treated with aggressive antiviral therapies. Brain pathology( urich, Switzerland)., e13069, 20220404 (doi.org/10.1111/bpa.13069)
20. Goichi Beck, Kazue Shigenobu, Koto Ukon, Rika Yamashita, Yuki Yonenobu, Eiichi Morii, Masato

Hasegawa, Manabu Ikeda, Shigeo Murayama, Hideki Mochizuki. An autopsy case of Alzheimer sdisease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like
psychiatric symptoms. Neuropathology:, official journal of the Japanese Society of Neuropathology.,
42,2: 147-154, 202204. (doi.org/10.1111/neup.12786)
21. Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka

Y, Miyahara H, Sone J, Hattori N, Yoshida M, Katsuno M, Sobue G. Motor neuron TDP-43
proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain. 2022 Aug
27 145(8):2769-2784. (doi: 10.1093/brain/awac091)
22. Ito Kawakami, Tetsuaki Arai, Kenji Ikeda, Kazuhiro Niizato, Kenichi Oshima, Haruhiko Akiyama.

Possible association of limbic tau pathology with psychosis or behavioral disturbances: Studies of two－－

autopsied psychiatric patients. Neuropathology:, official journal of the Japanese Society of
Neuropathology., 20221107, (doi.org/10.1111/neup.12870)
23. Ito Kawakami, Jun-Ichi Iga, Sho Takahashi, Yi-Ting Lin, Hiroshige Fujishiro. Towards anunderstanding of the pathological basis of senile depression and incident dementia: Implications fortreatment. Psychiatry and Clinical Neurosciences., 20221002, (doi.org/10.1111/pcn.13485)
24. Atsuko Motoda, Tomoyasu Matsubara, en-ichi Tanei, Yasuhiro Sakashita, Mikihiro Yamazaki, Ito

Kawakami, Renpei Sengoku, Tomio Arai, Hirofumi Maruyama, Yuko Saito, Shigeo Murayama.
Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber
density in elderly individuals. NEUROPATHOLOGY., 202208. (doi.org/10.1111/neup.12856)
25. Shunichiro Shinagawa, Ito Kawakami, Emi Takasaki, Masahiro Shigeta, Tetsuaki Arai, Manabu Ikeda.

The Diagnostic Patterns of Referring Physicians and Hospital Expert Psychiatrists Regarding Particular
Frontotemporal Lobar Degeneration Clinical and Neuropathological Subtypes. Journal of Alzheimer's
Disease: JAD., 20220602 (doi.org/10.3233/JAD-215516)
26. Ἑୖ ⥴ ရᕝ ಇ୍㑻 ᪂஭ ဴ᫂ Ọ಴ ᬡே ኱ᓥ ೺୍ ᪂㔛 ࿴ᘯ ❑⏣ ⨾ᜨ[ᆏୗ]㇂ཱྀ ኱♸ ᭹㒊 ಙᏕ ụ⏣ Ꮫ ຍ⸨ ᛅྐࠕ㉸᪩ᮇⓎ⑕ࡋࡓ๓㢌ഃ㢌ᆺㄆ▱⑕ࡢ⮫ᗋ⑓⌮≉ᚩࠖ(බ♫)᪥ᮏ⢭⚄⚄⤒Ꮫ఍ 124,4 ௜㘓 385 㡫 202204
27. Schweighauser M, Arseni D, Bacioglu M, Huang M, L vestam S, Shi Y, Yang Y, hang

, Kotecha

A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y,
Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M,
Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SH . Age-dependent
formation of TMEM106B amyloid filaments in human brains. Nature., 2022 May,
605(7909):310-3148.
28. Takahashi M, Takasugi T, Kawakami A,

ei R, Ando K, Ohshima T, Hisanaga SI. Valproic

Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient
Mice. Neurochem Res. 2022 Sep 47(9):2773-2779. (doi: 10.1007/s11064-022-03642-9)
29. Im DS, Joselin A, Svoboda D, Takano T, Rousseaux M C, Callaghan S, Slack RS, Hisanaga SI,

Davis RJ, Park DS, u D. Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowththrough Notch1 inhibition. BMC Biol. 2022 May 17 20(1):115. (doi:
10.1186/s12915-022-01312-4)
30. Kikuchi K, Sakamoto Y, Uezu A, Yamamoto H, Ishiguro KI, Shimamura K, Saito T, Hisanaga SI,

Nakanishi H. Map7D2 and Map7D1 facilitate microtubule stabilization through distinct
mechanisms in neuronal cells. Life Sci Alliance. 2022 Apr 25 5(8):e202201390. (doi:10.26508/lsa.202201390)
31. Hisanaga SI, Krishnankutty A, Kimura T. In vivo analysis of the phosphorylation of tau and thetau protein kinases Cdk5-SDQG*6.ȕE\XVLQJ3KRV-tag SDS-PAGE. J Proteomics. 2022 Jun－5 －30 262:104591. doi: 10.1016/j.jprot.2022.104591. Epub 2022 Apr 14.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 7 ௳㸧㛗㇂ᕝᡂே. ࢡࣛ࢖࢜㟁㢧ࡀゎࡁ᫂࠿ࡍ⚄⤒ኚᛶ⑌ᝈࡢ࣓࢝ࢽࢬ࣒. ௻⏬ࠊ⦅㞟ࠊᕳ㢌ࡢࡇ࡜ࡤ. ་Ꮫࡢ࠶ࡺࡳ 283(13): 2022ᖺ12᭶.

2.

ᶡ㇂ឡ⌮ࠊ㛗㇂ᕝᡂே. ࢱ࢘⥺⥔ᵓ㐀࡟ᇶ࡙࠸ࡓࢱ࢘࢜ࣃࢳ࣮ࡢ⑌ᝈศ㢮. ་Ꮫࡢ࠶ࡺࡳ
283(13): 2022ᖺ12᭶.

3.

㛗㇂ᕝᡂே. ALS ᝈ⪅⬻࡟⵳✚ࡍࡿ TDP-43 ⥺⥔ࡢᵓ㐀. ་Ꮫࡢ࠶ࡺࡳ 283(13): 2022 ᖺ
12 ᭶.

4.

ᶡ㇂ឡ⌮ࠊ㛗㇂ᕝᡂே. ␗ᖖᆺࢱ࢘ࡢᵓ㐀ከᆺࡣከᵝ࡞ࢱ࢘࢜ࣃࢳ࣮⑓⌮ࡢᙧᡂ࡟ᐤ୚ࡍ
ࡿ Brain & Nerve 74 (7), 919-925, 2022.

5.

Ἑୖ ⥴࠙⢭⚄⛉⮫ᗋ࡜⬻⛉Ꮫࡢ㊥㞳ࡣ⦰ࡲࡗࡓ࠿?-᭱᪂◊✲ࡢ⌧ሙ࠿ࡽࠚ⪁ᖺᮇࡢ⚄⤒⑓⌮Ꮫ◊✲ࡀࡶࡓࡽࡍᡂᯝ࡜ࡣ (ᰴ)ᫍ࿴᭩ᗑ 37 ᕳ 11 ྕ 1229-1233ࠊ202211

6.

Ἑୖ ⥴ ⢭⚄⛉࡟࠾ࡅࡿ๗᳨࣭CPC ࡢព⩏⮫ᗋ⢭⚄་Ꮫ 51 ᕳ 5 ྕ 535-540

2022057.

Ἑୖ ⥴ ධ㇂ ಟྖ 㛵ཱྀ ⿱Ꮥ Ἑୖ ⥴ ⸨ᇛ ᘯᶞ Huitinga Inge ࠙⢭⚄⛉ࣈࣞ࢖ࣥࣂ
ࣥࢡࠚ⢭⚄⛉ࣈࣞ࢖ࣥࣂࣥࢡ ୡ⏺࡜᪥ᮏࡢ⌧≧࡜ᮍ᮶ࠊ(᭷)⛉Ꮫホㄽ♫ 40 ᕳ 4 ྕ 407-415ࠊ
202204II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 13 ௳㸧
1.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶࡢཎᅉ࡜࡞ࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢ⏕໬Ꮫࠊᵓ㐀ゎᯒ. Movement
Disorders Conference. 2023 ᖺ 3 ᭶ 30 ᪥. (࢜ࣥࣛ࢖ࣥ㛤ദ).

2.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែᙧᡂ࡜㐍⾜ᶵᗎ ➨ 242 ᅇ⏕࿨⛉Ꮫࣇ࢛࣮࣒ࣛ. 2023 ᖺ
3 ᭶ 29 ᪥. ᪥ᮏグ⪅ࢡࣛࣈ.

3.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟࠾ࡅࡿ⑓ⓗࢱࣥࣃࢡ㉁ࡢ⵳✚࡜ఏ᧛. ௧࿴ 4 ᖺᗘ ᪥ᮏ⚄⤒Ꮫ఍஑ᕞᆅ༊⏕ᾭᩍ⫱ㅮ₇఍. 2023 ᖺ 3 ᭶ 26 ᪥㸦᪥㸧(࢜ࣥࣛ࢖ࣥ㛤ദ)

4.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ⬻࡟⵳✚ࡍࡿ⣽⬊ෆ␗ᖖࢱࣥࣃࢡ㉁⥺⥔ࡢᵓ㐀ゎᯒ.
Parkinson s Disease Meet The Expert in Miyagi. 2023 ᖺ 2 ᭶ 8 ᪥. (࢜ࣥࣛ࢖ࣥ㛤ദ)

5.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟⵳✚ࡍࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢ⏕໬Ꮫࠊᵓ㐀ゎᯒ. Nano tech2023 ➨ 22 ᅇᅜ㝿ࢼࣀࢸࢡࣀࣟࢪ࣮⥲ྜᒎ࣭ᢏ⾡఍㆟. 2023 ᖺ 2 ᭶ 3 ᪥. ᮾிࣅࢵࢡࢧ࢖
ࢺ.

－ 51 －

6.

㛗㇂ᕝᡂே. ALS ᝈ⪅⬻࡟⵳✚ࡍࡿ TDP-43 ⥺⥔ࡢᵓ㐀ゎᯒ. ➨ 6 ᅇ ࡏࡾ࠿ᇶ㔠 ཷ㈹ᘧ. 2022 ᖺ 12 ᭶ 16 ᪥. ᮾி (ࣁ࢖ࣈࣜࢵࢻ㛤ദ).

7.

㛗㇂ᕝᡂே. ࢱ࢘ࠊĮ ࢩࢾࢡࣞ࢖ࣥࠊTDP-43 จ㞟యࡢ❧యᵓ㐀. ➨ 41 ᅇ᪥ᮏㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍ ➨ 37 ᅇ᪥ᮏ⪁ᖺ⢭⚄་Ꮫ఍ ྜྠ㛤ദ. 2022 ᖺ 11 ᭶ 28 ᪥. ᮾி

8.

㛗㇂ᕝᡂே. Prion-OLNH SURSDJDWLRQ RI SDWKRORJLFDO ĮV\QXFOHLQ LQ 3' DQG UHODWHG GLVRUGHUV
Novartis Symposium on PD and Related Neurological Disorders (NSPD) 2022,

2022 ᖺ 11 ᭶

20 ᪥, Tokyo.
9.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟࠾ࡅࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢ⑓ኚᙧᡂᶵᵓ. Global NeuroCPC.
2022 ᖺ 9 ᭶ 12 ᪥. (࢜ࣥࣛ࢖ࣥ㛤ദ)

10. Hasegawa M. Molecular mechanisms of formation and propagation of pathological proteins inneurodegenerative diseases. The 2022 Tokizane Memorial Award. NEURO2022. July 1, 2022.
(Okinawa, Hybrid)
11. 㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟࠾ࡅࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢఏ᧛ᶵᵓ. ➨ 63 ᅇ ᪥ᮏ⚄⤒⑓⌮Ꮫ఍⥲఍Ꮫ⾡◊✲఍. 2022 ᖺ 6 ᭶ 25 ᪥. ி㒔.
12. 㛗㇂ᕝᡂே. ㄆ▱⑕ᝈ⪅⬻࡟⵳✚ࡍࡿ⑓ⓗࢱࣥࣃࢡ㉁ࡢ⏕໬Ꮫ. ᵓ㐀ゎᯒ ᩥ㒊⛉Ꮫ┬ ⛉Ꮫ◊✲㈝ Ꮫ⾡ኚ㠉㡿ᇦ◊✲ ࠗᏛ⾡◊✲ᨭ᥼ᇶ┙ᙧᡂ࠘⏕࿨⛉Ꮫ 4 ࣉࣛࢵࢺࣇ࢛࣮࣒ࠕᨭ
᥼ㄝ᫂఍࣭࢟ࢵࢡ࢜ࣇࢩ࣏ࣥࢪ࣒࢘ࠖ2022 ᖺ 6 ᭶ 3 ᪥. ᘺ⏕ㅮᇽ୍᮲࣮࣍ࣝ.
13. Hasegawa M. Biochemical distinction CBD/PSP. 63rd Annual Meeting of the Japanese Society of
Neurology. May 18, 2022. (Tokyo, Hybrid)ࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
1.

ุ⏣ຬ௓, ⏣Ἑ㡪, ᮃ᭶భ௓, ᒣᮏ࿴ᶞ, ຍ⸨ಟ᫂, ட㇂ᐩ⏤ᶞ, 㛵ᓥⰋᶞ, ▮ᓮṇⱥ ༑஧ᣦ⭠⚄⤒ෆศἪ୺せ㸦NET)࡟క࠺ AIAPP㸦࢔࣑ࣜࣥ㸧࢔࣑ࣟ࢖ࢻ࣮ࢩࢫ㸸ච␿⤌⧊໬Ꮫⓗ᥈⣴࡜ỿ╔࢔࣑ࣟ࢖ࢻࡓࢇࡥࡃࡢ⏕໬Ꮫⓗ≉ᚩ࡟ࡘ࠸࡚ ➨ 9 ᅇ᪥ᮏ࢔࣑ࣟ࢖ࢻ࣮
ࢩࢫᏛ఍Ꮫ⾡㞟఍

2022/10/16⚄ᡞࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮/රᗜ┴⚄ᡞᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧
࡞ࡋ

－5 －

IV. ≉グ஦㡯
1.

2022 ᖺᗘ ᫬ᐇ฼ᙪグᛕ㈹ ཷ㈹2.

2022 ᖺᗘ ࢡࣛࣜ࣋࢖ࢺᘬ⏝ᰤ㄃㈹ (Citation Laureate 2022) ཷ㈹－5 －ࣉࣟࢪ࢙ࢡࢺྡ

Ꮫ⩦グ᠈ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe. Dopamine activity in projection
neurons regulates short-lasting olfactory approach memory in Drosophila. The European journalof neuroscience., B, 20220711. (doi.org/10.1111/ejn.15766)

2.

Minoru Saitoe, Shintaro Naganos, Tomoyuki Miyashita, Motomi Matsuno, Kohei Ueno. A noncanonical on-demand dopaminergic transmission underlying olfactory aversive learning.
Neuroscience research., B178, 1-9, 202205. (doi.org/10.1016/j.neures.2021.12.008)

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 0 ௳㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

㛗㔝ៅኴ㑻, ୖ㔝⪔ᖹ, 㰺⸨classical conditioning

2.

㕥ᮌຊ᠇

ᐇ Post-associative dopamine release works as a reinforcer for2022 ᖺᗘグ᠈◊✲఍2022/9/7 ⮬↛⛉Ꮫ◊✲ᶵᵓ/ឡ▱┴ᒸᓮᕷ

Adaptive motor control via NMDA signaling in Drosophila ventral nerve cord ➨15 ᅇ᪥ᮏࢩࣙ࢘ࢪࣙ࢘ࣂ࢚◊✲㞟఍

2022/9/12㹼2022/9/14 ྡྂᒇ኱Ꮫᆏ⏣࣭ᖹ⏣࣮࣍ࣝࡑࡢ௚ 㸦ィ 10 ௳㸧⮬⏤ᥖ㍕

－5 －

1.

ᐑୗ▱அ ࢢࣜ࢔⣽⬊࠿ࡽࡢࢢࣝࢱ࣑ࣥ㓟ᑠ⬊㛤ཱྀᨺฟࡀ᎘ᝏᛶ㐃ྜᏛ⩦࡟࠾ࡅࡿ᎘ᝏ
᝟ሗࢆఏ㐩ࡍࡿ ࢢࣜ࢔ࢹࢥ࣮ࢻ➨ 5 ᅇ㡿ᇦ఍㆟ 2023/2/8㹼2023/2/9 ࣇࣛࢡࢩ࢔ရᕝ/ᮾி㒔

2.

ᮧ㇂᪥ྥᏊ NMDA ཷᐜయ Mg²ͻࣈࣟࢵࢡࢆᇶ┙࡜ࡋࡓ㏫⾜᮲௳௜ࡅᡂ❧ᢚไ࣓࢝ࢽࢬ
࣒ࡢゎ᫂ ࢢࣜ࢔ࢹࢥ࣮ࢻ➨ 5 ᅇ㡿ᇦ఍㆟ 2023/2/8㹼2023/2/9

ࣇࣛࢡࢩ࢔ရᕝ/ᮾி㒔
3.

ᐑୗ▱அ ឤぬ᝟ሗࢆఏ㐩ࡍࡿࢢࣜ࢔⣽⬊ࡢࢹࢥ࣮ࢹ࢕ࣥࢢ

ࢢࣜ࢔⣽⬊࠿ࡽࡢࢢࣝࢱ

࣑ࣥ㓟ᑠ⬊㛤ཱྀᨺฟࡀ᎘ᝏᛶ㐃ྜᏛ⩦ᡂ❧࡟ᚲせ࡞ࢻ࣮ࣃ࣑ࣥࡢᨺฟࢆไᚚࡍࡿ ࢢࣜ࢔ࢥࢹ࣮ࢺⱝᡭࡢ఍ 2022/9/30㹼2022/10/2
4.

ி㒔኱Ꮫ/ி㒔ᕷᮧ㇂᪥ྥᏊ ឤぬ᝟ሗࢆఏ㐩ࡍࡿࢢࣜ࢔⣽⬊ࡢࢹࢥ࣮ࢹ࢕ࣥࢢ NMDA ཷᐜయ࡜ࢻ࣮ࣃ
࣑ࣥཷᐜయࡢࢩࢢࢼࣝ⤫ྜ࡟ࡼࡿ㏫⾜᮲௳௜ࡅᡂ❧ࡢᢚไ ࢢࣜ࢔ࢥࢹ࣮ࢺⱝᡭࡢ఍
2022/9/30㹼2022/10/2 ி㒔኱Ꮫ/ி㒔ᕷ5.

ᯇ㔝ඖ⨾ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᡂ⹸⬻࡟࠾ࡅࡿࢻ࣮ࣃ࣑ࣥཷᐜయ࡜ࢻ࣮ࣃ࣑ࣥࢺࣛࣥࢫ࣏
࣮ࢱ࣮ࡢᒁᮦ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3 web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ

6.

ᐑୗ▱அ ໝ࠸᎘ᝏᏛ⩦࡟࠾ࡅࡿ NMDA ཷᐜయ࡜ࢻ࣮ࣃ࣑ࣥཷᐜయࡢࢩࢢࢼࣝࡢ⤫ྜ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3

web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥ

ࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ
7.

ᮧ㇂᪥ྥᏊ ໝ࠸᎘ᝏᏛ⩦࡟࠾ࡅࡿ NMDA ཷᐜయ࡜ࢻ࣮ࣃ࣑ࣥཷᐜయࡢࢩࢢࢼࣝࡢ⤫ྜ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3 web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥ

ࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ
8.

㕥ᮌຊ᠇ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡟࠾ࡅࡿᰂ㌾࡞㐠ືไᚚࡢ⚄⤒ศᏊᇶ┙ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3 web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ9.

㛗㔝ៅኴ㑻 ໝ࠸グ᠈ಖᣢ࡟ᚲせ࡞᮲௳௜ᚋࡢࢻ࣮ࣃ࣑ࣥᨺฟࢆไᚚࡍࡿ⚄⤒ᶵᵓ ➨45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3 web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ
࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ

10. ୖ㔝⪔ᖹ,㛗㔝ៅኴ㑻, 㰺⸨ ᐇࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢໝ࠸㐃ྜᏛ⩦࡟࠾ࡅࡿ㸰ࡘࡢࢻ࣮ࣃ࣑ࣥᨺฟᵝᘧ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3 web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧

－ 55 －

IV. ≉グ஦㡯－ 56 －

ࣉࣟࢪ࢙ࢡࢺྡ

⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 10 ௳㸧
1.

Obara K, Kaneshige M, Suzuki M, Yokoyama O, Tazoe T, Nishimura Y. Corticospinal interface
to restore voluntary control of joint torque in a paralyzed forearm following spinal cord injury in
non-human primates. Frontiers in Neuroscience, 07 March 2023,
https://doi.org/10.3389/fnins.2023.1127095

2.

Kaneshige M, Obara K, Suzuki M, Tazoe T, Nishimura Y. Tuning of motor outputs produced byspinal stimulation during voluntary control of torque directions in monkeys. eLife, 2022 Dec
13 11:e78346. doi: 10.7554/eLife.78346.

3.

Umeda T, Isa T, Nishimura Y. Temporal dynamics of the sensorimotor convergence underlying
voluntary limb movement. Proceedings of the National Academy of Sciences 2022 Nov
29 119(48):e2208353119. doi: 10.1073/pnas.2208353119.

4.

Insausti-Delgado A, L pez-Larraz E, Nishimura Y, iemann U, Ramos-Murguialday A. Noninvasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG.
Front Bioeng Biotechnol. 2022 Oct 31 10:975037. doi: 10.3389/fbioe.2022.975037. eCollection
2022.

5.

Kawai K, Tazoe T, Yanai T, Kanosue K, Nishimura Y. Activation of human spinal locomotor
circuitry using transvertebral magnetic stimulation. Frontiers in Human Neuroscience 2022
Sep23 16:1016064. doi: 10.3389/fnhum.2022.1016064

6.

Suzuki M, Nishimura Y. The ventral striatum contributes to the activity of the motor cortex andmotor outputs in monkeys. Frontiers in Systems Neuroscience, 2022 Aug 29 16:979272. doi:
10.3389/fnsys.2022.979272

7.

Usuda N, Sugawara S.K, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y. uantitative
comparison of corticospinal tracts arising from different cortical areas in humans. Neuroscience
Research, 2022 Jul 1 S0168-0102(22)00189-4. doi: 10.1016/j.neures.2022.06.008.㸦ᰝㄞ᭷㸧8.

Nakayama Y, Sugawara S.K, Fukunaga M, Hamano Y.H, Sadato N, Nishimura Y. The dorsal
premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior inhumans. NeuroImage, 2022 Aug 1 256:119221. doi: 10.1016/j.neuroimage.2022.119221.䠄ᰝㄞ᭷㸧－ 57 －

9.

Ninomiya T, Nakagawa H, Inoue K, Nishimura Y, Oishi T, Yamashita T, Takada M. Origin ofMultisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization
After Spinal Cord Injury. Frontiers in Neural Circuits,2022 Apr 6 16:847100. doi: 10.3389/
fncir.2022.847100㸦ᰝㄞ᭷㸧

10. Suzuki M, Inoue KI, Nakagawa H, Ishida H, Kobayashi K, Isa T, Takada M, Nishimura Y. A
multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. The
Journal of physiology . 2022 Apr 600(7):1731-1752. doi: 10.1113/JP282429.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 9 ௳㸧࠙⥲ㄝㄽᩥࠚ
1.

㕥ᮌ㏔ㄹࠊすᮧᖾ⏨ ពḧࡀ㌟య㐠ື࡟ᙳ㡪ࢆཬࡰࡍ⚄⤒ᇶ┙ య⫱ࡢ⛉Ꮫ ➨ 73 ᕳ 5
᭶ྕ, 296-300, May 1, 2023

2.

⏣ῧṓᶞࠊすᮧᖾ⏨ ேᕤ⚄⤒᥋⥆ࢆ⏝࠸ࡓ⬻࣭⬨㧊ᦆയᚋࡢ㌟య㐠ືᶵ⬟ࡢ෌ᘓ
BRAIN and NERVE

2022 Sep 74(9):1111-1116. doi: 10.11477/mf.1416202190.

࠙㞧ㄅ࣭᪂⪺➼ࠚ
1.

すᮧᖾ⏨ 2022.12 .15 Yano E plusࠕ᭱᪂⬻⛉Ꮫ࡜ᛂ⏝㸦㸯㸧㹼⬻ࡢ⚄⤒ᅇ㊰ᶵᵓ㹼ࠖNo.177, 2022.12, 77-81 㡫㸧࡟ࠕேᕤ⚄⤒᥋⥆࣭⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺࠖグ஦ᥖ㍕
㸦ᰴ㸧▮㔝⤒῭◊✲ᡤ2.

୰ᒣ⩏ஂ 2022.12.6 ẖ᪥᪂⪺࣭ᮅห 16 㠃ࠕ࢔ࢡࢭࣝ࡜ࣈ࣮ࣞ࢟ࠊ࡞ࡐ㋃ࡳ㛫㐪࠺㸽⬻ࡢࠗ㐠ື๓㔝࠘࡟⛎ᐦࠖ

3.

すᮧᖾ⏨ 2022.10.7 ᮅ᪥᪂⪺࣭ᮅห ࠕኻࡗࡓ㐠ືᶵ⬟ ᚟ά࡛ࡁࡿ㸽ࠖ

4.

୰ᒣ⩏ஂ 2022.10 㒔་Ꮫ◊ NE S No.047

Topics ᥖ㍕ࠕࣄࢺࡢ๓㢌ⴥࠗ㐠ື๓㔝࠘ࡣ」ᩘࡢ㡿ᇦࡀᙺ๭ศᢸࡍࡿࡇ࡜࡛┠ⓗ㐩ᡂࡢࡓࡵࡢ⾜ືࢆᐇ⌧ࡉࡏ࡚࠸ࡿࠖ
5.

すᮧᖾ⏨

2022 ᖺ 8 ᭶ 28 ᪥ᨺ㏦ BS ࣇࢪࠗ࢞ࣜࣞ࢜

࠘ࠕ࡞ࡐ࢝ࣛࢲࡣືࡃࡢ࠿

⚄⤒࣭ᚰ࣭➽⫗ࡢ㛵ಀࠖ
6.

㕥ᮌ㏔ㄹ 2022.06 㒔་Ꮫ◊ NE S No.046 Topics ᥖ㍕ࠕືᶵ࡙ࡅࢆྖࡿ⬻㡿ᇦࡀ➽άືࢆ⏕ࡳฟࡍࡇ࡜ࢆⓎぢ㹼ᚰ࡜㌟యࢆ⧅ࡄ⚄⤒⤒㊰㹼ࠖ7.

୰ᒣ⩏ஂ 2022.07.25 Active

Brain CLUBII. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧࠙ᅜ㝿Ꮫ఍㸸ᣍᚅㅮ₇ࠚ－5 －eb ࢧ࢖ࢺ◊✲⤂௓

1.

Nishimura Y. Neural interface ࡟ࡼࡿ artificial neural connection. ASENT2023 Annual Meeting
Virtual Neurotherapeutics Conference㸦2023.3.14

eb 㛤ദ㸧ࡑࡢ௚ 㸦ィ 23 ௳㸧⮬⏤ᥖ㍕
࠙ᅜ㝿Ꮫ఍ࠚ
1.

Kawai K, Tazoe T, Nishimura Y. Stimulus intensity- and location-specific activation of humanlocomotor circuitry by non-invasive transvertebral magnetic stimulation. 51st annual meeting of
the Society for Neuroscience (2022.11.12-16 San Diego, U.S.A)

2.

Tazoe T, Murayama T, Tosaka T, Kaneshige M, Suzuki M, Kikuchi N, Ugawa Y, Nishimura Y.
Reorganization of human spinal locomotor circuitry after spinal cord injury. 51st annual meetingof the Society for Neuroscience (2022.11.12-16 San Diego, U.S.A)

3.

Nakayama Y, Yokoyama O, Hoshi E, Nishimura Y. Evolving contralateral dominance of hand
movements from the caudal cingulate motor area to the primary motor cortex via the
supplementary motor area in monkeys. 51st annual meeting of the Society for Neuroscience(2022.11.12-16 San Diego, U.S.A)

4.

Sugawara S.K, Nakayama Y, Yamamoto T, Hamano H.Y, Fukanaga M, Sadato N, Nishimura Y.
The ventral midbrain commonly representing approach and avoidance motivations encodes futureforce generation. 51st annual meeting of the Society for Neuroscience (2022.11.12-16 San Diego,
U.S.A)

5.

Usuda N, Sugawara S.K, Fukuyama H, Nakazawa K, Amemiya K, Nishimura Y. uantitative
comparison of corticospinal tracts in humans based on diffusion fiber tractography. 51st annual
meeting of the Society for Neuroscience (2022.11.12-16 San Diego, U.S.A)

6.

Suzuki M, Kobayashi K, Nishimura Y. Chemogenetic activation of convergent inputs to the spinal
motoneurons enhances motor outputs in monkeys. 51st annual meeting of the Society for
Neuroscience (2022.11.12-16 San Diego, U.S.A)

7.

Obara K, Kaneshige M, Suzuki M, Tazoe T, Nishimura Y. Adaptation to cortico-spinal interface
to restore forearm paralysis in spinal cord injury. 51st annual meeting of the Society for
Neuroscience (2022.11.12-16 San Diego, U.S.A)

8.

Sugawara S.K. Pre-movement spinal cord activity in humans: a simultaneous brain-spinal cord
fMRI study. FENS FORUM 2022. (2022.7.9-13 Paris France)࠙ᅜෆᏛ఍ࠚ
1.

㕥ᮌ㏔ㄹ ࢧࣝ㢁㧊࡬ࡢ཰᮰ࢽ࣮ࣗࣟࣥ⩌ࡢ໬Ꮫ㑇ఏᏛⓗ㈿ά࡟ࡼࡿୖ⫥㐠ືࣃࣇ࢛࣮
࣐ࣥࢫቑᙉ

2.

᪥ᮏ⏕⌮Ꮫ఍➨ 100 ᅇグᛕ኱఍㸦2023.3.14 ி㒔㸧Ἑᮧᚰ ➽㟁άືࢆண ࡍࡿィ⟬ㄽⓗࣔࢹࣝࡣ኱⬻⓶㉁࡜➽⫗ࡢ㛫ࡢᶵ⬟ⓗ࡞⚄⤒⤖ྜࢆ཯ᫎࡋ࡚ண ࢆ⾜ࡗ࡚࠸ࡿ᪥ᮏ⏕⌮Ꮫ఍➨ 100 ᅇグᛕ኱఍㸦2023.3.14

－5 －

ி㒔㸧

3.

㕥ᮌ㏔ㄹࠊᑠᯘ᠇ኴࠊすᮧᖾ⏨ ࢧࣝ㢁㧊࡬ࡢ཰᮰ࢽ࣮ࣗࣟࣥ⩌ࡢ໬Ꮫ㑇ఏᏛⓗ࡞άᛶ໬࡟ࡼࡿୖ⫥㐠ືࣃࣇ࢛࣮࣐ࣥࢫࡢቑᙉ ➨ 16 ᅇ Motor Control ◊✲఍ ᪩✄⏣኱Ꮫᅜ㝿఍㆟ሙ㸦2022.8.25-27 ᮾி㸧

4.

ᑿཎᆂࠊව㔜⨾ᕼࠊ㕥ᮌ㏔ㄹࠊᶓᒣಟࠊ⏣ῧṓᶞࠊすᮧᖾ⏨ ேᕤⓗ࡞⓶㉁-⬨㧊㊰࡟ᑐࡋ࡚⬨㧊ᦆയࣔࢹࣝࢧࣝࡣ኱⬻⓶㉁㐠ື㔝ࡢࢽ࣮ࣗࣟࣥ⩌ࢆ㐺ᛂࡉࡏࡿ ➨ 16 ᅇ Motor
Control ◊✲఍ ᪩✄⏣኱Ꮫᅜ㝿఍㆟ሙ㸦2022.8.25-27

5.

ᶓᒣಟࠊ㕥ᮌ㏔ㄹࠊすᮧᖾ⏨ᮾி㸧㝶ព㐠ື࡟࠾ࡅࡿ୍ḟ㐠ື㔝-୍ḟయᛶឤぬ㔝㛫ࡢ㐠ື㐣⛬࣭࿘Ἴᩘ౫Ꮡⓗ࡞཮᪉ྥ᝟ሗఏ㐩➨ 16 ᅇ Motor Control ◊✲఍ ᪩✄⏣኱Ꮫᅜ㝿఍㆟ሙ㸦2022.8.25-27 ᮾி㸧
6.

ව㔜⨾ᕼࠊᑿཎᆂࠊ㕥ᮌ㏔ㄹࠊ⏣ῧṓᶞࠊすᮧᖾ⏨⬨㧊ᦆയᚋࡢ㐠ືᶵ⬟ࡢᅇ᚟㐣⛬࡟࠾࠸࡚ࠊቑ኱ࡋࡓ⬨㧊ࡢ࢔࢘ࢺࣉࢵࢺࡣࠊ୍ḟ㐠ື㔝⚄⤒⣽⬊άືࡢኚㄪࡢῶᑡ࡜㛵㐃ࡍࡿ ➨ 16 ᅇ Motor Control ◊✲఍ ᪩✄⏣኱Ꮫᅜ㝿఍㆟ሙ㸦2022.8.25-277.

ᮾி㸧⏣ῧṓᶞࠊᮧᒣᑛྖࠊᡞᆏ཭ஓࠊව㔜⨾ᕼࠊ㕥ᮌ㏔ㄹࠊ⳥ᆅᑦஂࠊᏱᕝ⩏୍ࠊすᮧᖾ⏨᏶඲⬨㧊ᦆയ⪅࡟࠾ࡅࡿ⬨㧊Ṍ⾜୰ᯡࡢάືஹ㐍 ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍
㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧8.

ව㔜⨾ᕼࠊᑿཎᆂࠊ㕥ᮌ㏔ㄹࠊ⏣ῧṓᶞࠊすᮧᖾ⏨⬨㧊ᦆയᚋࡢ㐠ືᶵ⬟ᅇ᚟࡟࠾ࡅ

ࡿୖ᪼ࡋࡓ⬨㧊ࡢ࢔࢘ࢺࣉࢵࢺࡣࠊ㐠ື㔝⚄⤒⣽⬊άືࡢኚ໬࡜㛵㐃ࡍࡿ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧9.

୰ᒣ⩏ஂࠊబ㔝ᬸဢࠊ▱ぢ⪽⨾ࠊ༡㒊⠜ࠊすᮧᖾ⏨ୖ⫥฿㐩㐠ືࡢไᚚ㐣⛬࡟ᑠ⬻ࢆ㉳Ⅼ࡜ࡋ➽⫗࡟⮳ࡿ⚄⤒⤒㊰ࡀ㛵୚ࡍࡿ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖
/Hybrid 㛤ദ㸧10. Ⳣཎ⩧ࠊ⮻⏣༖ࠊ⚟ᒣ༤ᖾࠊ㞵ᐑࡁࡼࡳࠊすᮧᖾ⏨࡟㛵ࢃࡿ⚄⤒ᇶ┙㐠ືࣃࣇ࢛࣮࣐ࣥࢫࡢ㛗ᮇⓗኚື➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧11. 㕥ᮌ㏔ㄹࠊᑠᯘ᠇ኴࠊすᮧᖾ⏨ ໬Ꮫ㑇ఏᏛⓗᡭἲ࡟ࡼࡿୗ⾜ᛶ㐠ື㊰ࡢάᛶ໬ࡣ➽άືࢆ㧗ࡵࡿ

➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧12. ⮻⏣༖ࠊⳢཎ⩧ࠊ⚟ᒣ༤ᖾࠊ㞵ᐑࡁࡼࡳࠊすᮧᖾ⏨ࣄࢺྠഃ⓶㉁⬨㧊㊰ࡢᐃ㔞ẚ㍑➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧13. ᑿཎᆂࠊව㔜⨾ᕼࠊ㕥ᮌ㏔ㄹࠊ⏣ῧṓᶞࠊすᮧᖾ⏨ேᕤⓗ࡞⓶㉁⬨㧊㊰࡬ࡢ㐺ᛂ࡟క࠺⬨㧊ᦆയࢧࣝࡢ୍ḟ㐠ື㔝ࢽ࣮ࣗࣟࣥ⩌ࡢྠㄪ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍
㸦2022.6.29-7.3,Ἀ⦖/Hybrid 㛤ദ㸧14. ᱵ⏣㐩ஓࠊఀబṇࠊすᮧᖾ⏨㝶ព㐠ື࡟࠾࠸࡚ୗ⾜ᛶධຊ࡜ឤぬࣇ࢕࣮ࢻࣂࢵࢡಙྕ

ࡣ㐃⥆ⓗ࡟➽άື⏕ᡂ࡟ᐤ୚ࡍࡿ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.29-7.3,Ἀ⦖/Hybrid㛤ദ㸧
15. ఀໃᓮ㝯ྖࠊ㕥ᮌ㏔ㄹࠊ㟷ᮌⰋ㍜ࠊᑠụᖾ⏕ࠊすᮧᖾ⏨

GBoost ࢆ⏝࠸ࡓࢧࣝࡢ⓶㉁⬻Ἴ࡟ᇶ࡙ࡃ๓⫥➽άືࢹࢥ࣮ࢹ࢕ࣥࢢࡢ᳨ウ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍㸦2022.6.297.3,Ἀ⦖/Hybrid 㛤ദ㸧－6 －III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧
1.

すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆㹼ࢥࢥࣟ࡜㌟యࢆࡘ࡞ࡄ㹼ࢥ࣮ࢫࠕ⬻࡜೺ᗣࠖ㹼⬻࡜᝟ሗᢏ⾡࠿ࡽ⪃࠼ࡿᛂ⏝⬻⛉Ꮫ࢔࢝ࢹ࣑࣮࢔ࢻࣂࣥࢫ

ell-being㹼➨㸲ᅇ ୍⯡♫ᅋἲேᛂ⏝⬻⛉Ꮫࢥࣥࢯ࣮ࢩ࢔࣒㸦2022.9.27 ᮾி / Hybrid 㛤ദ㸧2.

Ⳣཎ⩧ ⬻ࡣ࡝ࡢࡼ࠺࡟ឤ᝟ࡸពḧࢆไᚚࡍࡿ㸽 ୡ⏺⬻㐌㛫⾜஦ㅮ₇఍ ᮾிᏛⱁ኱
Ꮫ㝃ᒓ㧗➼Ꮫᰯ㸦2022.11.28

3.

ᮾி㸧

すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ࡼࡿ⬻ᶵ⬟෌ᘓࣈ࣮ࢫᒎ♧ TOBIRA ➨ 10 ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ㸦2022.6.10 ᮾி㸧
4.

ᑿཎᆂ ேᕤⓗ࡞⓶㉁⬨㧊㊰࡬ࡢ㐺ᛂ࡟క࠺⬨㧊ᦆയࢧࣝࡢ୍ḟ㐠ື㔝ࢽ࣮ࣗࣟࣥ⩌ࡢྠㄪ࣏ࢫࢱ࣮Ⓨ⾲TOBIRA ➨ 10 ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ㸦2022.6.10 ᮾி㸧

IV. ≉グ஦㡯䛆ጤဨ➼䛇1.

すᮧᖾ⏨ ᪥ᮏᏛ⾡᣺⯆఍ ⛉Ꮫ◊✲㈝ጤဨ఍ᑓ㛛ጤဨ

2.

すᮧᖾ⏨ ࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ(ࢽ࣍ࣥࢨࣝ)ᥦ౪᳨ウጤဨ఍ጤဨ

3.

すᮧᖾ⏨ Motor Control ◊✲఍⌮஦

4.

すᮧᖾ⏨ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ᐇ㦂ື≀⟶⌮⪅5.

Ⳣཎ⩧ ࣄࢺ⬻࢖࣓࣮ࢪࣥࢢ◊✲఍

6.

Ⳣཎ⩧

7.

Ⳣཎ⩧ ᪥ᮏᏛ⾡᣺⯆఍ ≉ู◊✲ဨ஦ᴗ➼ࠊᑂᰝ఍ᑓ㛛ጤဨ

8.

⏣ῧṓᶞ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ேᑐ㇟◊✲೔⌮ᑂᰝጤဨ఍ጤဨ

9.

⏣ῧṓᶞ Editorial board member, Journal of Neurophysiologyⱝᡭ࣮࣡࢟ࣥࢢࢢ࣮ࣝࣉጤဨ㛗

Review editor, Frontiers in Human Neuroscience

10. ⏣ῧṓᶞ Review editor, Frontiers in Human Neuroscience䛆ᩍ⫱άື䛇
1.

すᮧᖾ⏨ ᪩✄⏣኱Ꮫ⌮ᕤᏛ⾡㝔 ඛ㐍⌮ᕤᏛ㒊 㟁Ẽ࣭᝟ሗ⏕࿨ᕤᏛ⛉ 㠀ᖖ໅ㅮᖌ

2.

すᮧᖾ⏨ ᪂₲኱Ꮫ㐃ᦠ኱Ꮫ㝔 ᐈဨᩍᤵ3.

すᮧᖾ⏨ 㒔་Ꮫ◊ 㐃ᦠ኱Ꮫ㝔ㄝ᫂఍࡛ࡢㅮ₇ࠕேᕤ⚄⤒᥋⥆࡟ࡼࡿ⬻ᶵ⬟෌ᘓ-ᇶ♏
◊✲࠿ࡽ⮫ᗋ◊✲ࡲ࡛ࡢᶫΏࡋࠖ

4.

୰ᒣ⩏ஂ ᪥ᮏ኱Ꮫ⏕⏘ᕤᏛ㒊 㠀ᖖ໅ㅮᖌ ᢸᙜ⛉┠㸸ᚰ⌮Ꮫࠊᚰ⌮Ꮫ(S)5.

ᶓᒣಟ ᮾὒ኱Ꮫ♫఍Ꮫ㒊㠀ᖖ໅ㅮᖌ ⚄⤒࣭⏕⌮ᚰ⌮Ꮫᇶ♏ࠊ⚄⤒࣭⏕⌮ᚰ⌮Ꮫ

－ 61 －

6.

◊ಟ⏕ཷࡅධࢀ ᪂₲኱Ꮫ኱Ꮫ㝔 ་ṑᏛ⥲ྜ◊✲⛉㸦㸯ྡ㸧ࠊᮾ໭኱Ꮫ኱Ꮫ㝔 ་Ꮫ◊✲⛉㸦㸯ྡ㸧ᮾி㒔❧⏘ᴗᢏ⾡ᑓ㛛Ꮫᰯ㸦㸯ྡ㸧ᮾி⌮⛉኱Ꮫ㸦㸯ྡ㸧

䛆ཷ㈹䛇
2023 ᖺ Neuroscience Research (NSR) ㄽᩥ㈹

1.

⮻⏣༖

2.

ᾆ୸ᾈ୍ 2022 ᖺᗘ ᡤෆ◊✲Ⓨ⾲఍ ➨ 3 㒊఍ ඃ⚽Ⓨ⾲⪅3.

ᑿཎᆂ ➨ 16 ᅇ Motor Control ◊✲఍ ⱝᡭ◊✲⪅ዡບ㈹ ཷ㈹

－6 －

ཷ㈹

ࣉࣟࢪ࢙ࢡࢺྡ

ࡇ࡝ࡶࡢ⬻ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 13 ௳㸧
1.

Yuka Murofushi, Hiroshi Sakuma, Hiroko Tada, Masashi Mizuguchi, Jun-Ichi
Takanashi. Changes in the treatment of pediatric acute encephalopathy in Japanbetween 2015 and 2021: A national questionnaire-based survey. Brain &development., C 45, 3: 153-160, 202303. (doi.org/10.1016/j.braindev.2022.10.008)

2.

Sakuma H* & Takanashi JI, Muramatsu K, Kasai M, Tada H, Mizuguchi M, et al.
Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2. Front
Neurosci. 2023 17: 1085082.20230207 (doi: 10.3389/fnins.2023.1085082.)

3.

Keisuke Hatano, Ayataka Fujimoto, Keishiro Sato, Takamichi Yamamoto, Hiroshi
Sakuma, Hideo Enoki. Unexplained Progressive Neurological Deficits after Corpus
Callosotomy May Be Caused by Autoimmune Encephalitis: A Case of Suspected
Postoperative Anti-NMDAR Encephalitis. Brain Sciences., 13,1: 20230112.
(doi.org/10.3390/brainsci13010135)

4.

Kazumi Tomioka, Masahiro Nishiyama, Shoichi Tokumoto, Hiroshi Yamaguchi,
Kazunori Aoki, Yusuke Seino, Daisaku Toyoshima, Hiroshi Kurosawa, Hiroko Tada,
Hiroshi Sakuma, Kandai Nozu, Azusa Maruyama, Ryojiro Tanaka, Kazumoto Iijima,
Hiroaki Nagase. Time course of serum cytokine level changes within 72hrs after onset
in children with acute encephalopathy and febrile seizures. BMC Neurology., 23,1:
7-7, 20230107. (doi.org/10.1186/s12883-022-03048-8)

5.

Naohiro Yamamoto, Takeshi Inoue, Ichiro Kuki, Kohei Matsubara, Naoki Yamada,Shizuka Nagase-Oikawa, Keisuke Oki, Megumi Nukui, Shin Okazaki, Hiroshi
Sakuma, Akio Kimura, Takayoshi Shimohata, Hisashi Kawawaki. A pediatric case of
autoimmune glial fibrillary acidic protein astrocytopathy with unique brain imaging
patterns and increased cytokines/chemokines. Brain & Development., C 44,10:753-758, 202211. (doi.org/10.1016/j.braindev.2022.06.011)

6.

Satoru Ochiai, Itaru Hayakawa, Eri Ohashi, Sho Hamano, Yohane Miyata, Hiroshi
Sakuma, Keita Hogetsu, Yoshihiro Gocho, Masao Ogura, Toru Uchiyama, Yuichi Abe.
Fatal X-linked lymphoproliferative disease type 1-associated limbic encephalitis withpositive anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
antibody. Brain & Development., C 44, 9: 630-634, 202210(doi.org/10.1016/j.braindev.2022.06.004)

7.

Naoki Yamada, Ichiro Kuki, Taeka Hattori, Naohiro Yamamoto, Shizuka Nagase,
Megumi Nukui, Takeshi Inoue, Shin Okazaki, Hisashi Kawawaki, Asako Horino,
Hiroshi Sakuma. Late relapse of anti-N-methyl-d-aspartate receptor encephalitis withamusia and transiently reduced uptake in 123I-iomazenil single-photon emission
computed tomography. Brain & Development., C 44,8: 558-561, 202209.
(doi.org/10.1016/j.braindev.2022.05.003)
－6 －

8.

Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro
Nakashima, Hiroshi Sakuma. Complement-dependent cytotoxicity of humanautoantibodies against myelin oligodendrocyte glycoprotein. Frontiers in
Neuroscience., 17, 1014071-1014071, 2023 (doi.org/10.3389/fnins.2023.1014071)

9.

Tadayuki Shimada, Kanato Yamagata. Spine morphogenesis and synapse formationin tubular sclerosis complex models. Frontiers in Molecular Neuroscience., 15,1019343-1019343, 2022. (doi.org/10.3389/fnmol.2022.1019343)

10. Katoh Y, Iriyama T, Kotajima-Murakami H, Sakuma H, Ikeda K, Osuga Y, et al.
Increased production of inflammatory cytokines and activation of microglia in the
fetal brain of preeclamptic mice induced by angiotensin II. J Reprod Immunol.
2022;154:103752. Doi: 10.1016/j.jri.2022.103752.
11. Yamamoto N, Inoue T, Kuki I, Okazaki S, Sakuma H, Kawawaki H, et al. A pediatriccase of autoimmune glial fibrillary acidic protein astrocytopathy with unique brain
imaging patterns and increased cytokines/chemokines. Brain Dev. 2022;44:753-758.
Doi: 10.1016/j.braindev.2022.06.011.
12. Fujita Y, Imataka G, Sakuma H, Takanashi JI, Yoshihara S. Multiple encephalopathy
syndrome: a case of a novel radiological subtype of acute encephalopathy in childhood.
Eur Rev Med Pharmacol Sci. 2022;26:5729-5735. Doi: 10.26355/eurrev_202208_29509.
13. Ochiai S, Hayakawa I, Ohashi E, Miyata Y, Sakuma H, Abe Y, et al. Fatal X-linked
lymphoproliferative disease type 1-associated limbic encephalitis with positiveanti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody.
Brain Dev. 2022 ;44:630-634. Doi: 10.1016/j.braindev.2022.06.004.
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 4 ௳㸧࠙㞧ㄅ⦅㞟ࠚ
1. Topic Editor: Infection-Triggered Encephalopathy Syndromes as Emerging Pediatric
Neuroinflammatory Diseases, Frontiers in Neuroscience, 20220727
࠙ሗ࿌᭩ࠚ
2. బஂ㛫ၨ㸬࡚ࢇ࠿ࢇ㛵㐃⑌ᝈ࡟࠾ࡅࡿᣦᐃ㞴⑓࡜ᑠඣ៏ᛶ≉ᐃ⑌⑓ࡢᑐᛂ≧ἣ㸬ཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ࠕ⛥ᑡ࡚ࢇ࠿ࢇ࡟㛵ࡍࡿໟᣓⓗ◊✲ࠖ௧࿴
4 ᖺᗘศᢸ◊✲ሗ࿌᭩
3. బஂ㛫ၨ㸬᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕࡟క࠺ᑠඣᛴᛶ⬻⑕࡟㛵ࡍࡿ඲ᅜㄪᰝ㸬ཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ࠕᑠඣᛴᛶ⬻⑕ࡢ᪩ᮇデ᩿࣭᭱㐺἞⒪࣭࢞࢖ࢻࣛ࢖ࣥ⟇ᐃ࡟ྥࡅࡓయไᩚഛࠖ௧࿴ 4 ᖺᗘศᢸ◊✲ሗ࿌᭩
4. బஂ㛫ၨ㸬ᑠඣ⮬ᕫච␿ᛶ⬻⅖ࡢデ᩿࡟࠾ࡅࡿ㧊ᾮ୰ࢧ࢖ࢺ࢝࢖ࣥࡢ ᐃព⩏㸬ཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠㸦᪂⯆࣭෌⯆ឤᰁ⑕ཬࡧண㜵᥋✀ᨻ⟇᥎㐍◊✲஦ᴗ㸧ࠕᑠᛴᛶᘱ⦆ᛶ㯞⑷➼ࡢ⚄⤒⑌ᝈ࡟㛵ࡍࡿ⥙⨶ⓗ⑓ཎయ᳨⣴ࢆྵࡵࡓཎᅉཬࡧ⑓ែࡢ✲᫂ࠊ἞⒪ἲࡢ☜❧࡟㈨ࡍࡿ⮫ᗋ␿Ꮫ◊✲ࠖ௧࿴ 4 ᖺᗘศᢸ◊✲ሗ࿌᭩－6 －II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧
1.

Sakuma H. COVID-19-associated acute encephalopathy. 17th Asian Society for PediatricResearch Congress. 2022.9.16-18 (9/17), Virtual.

2.

బஂ㛫ၨ㸬ᢠ myelin oligodendrocyte glycoprotein (MOG) ᢠయ㛵㐃⑌ᝈࡢ⮫ᗋ㸬➨ 64 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍㸬

3.

2022.6.2ࠥ4 (6.2). 㧗ᓮబஂ㛫ၨ㸬⬨㧊ᛶ➽ⴎ⦰⑕ࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ㸬ጤဨ఍ࢭ࣑ࢼ࣮ࠕ⬨㧊ᛶ➽ⴎ⦰⑕ࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ㸸⌧≧࡜ㄢ㢟ࠖ㸬➨ 64 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍㸬
2022.6.2ࠥ4 (6.2). 㧗ᓮ

4.

బஂ㛫ၨ㸬Overview: Immune therapy for autoimmune encephalitis. International Session: Cutting
Edge: Treatment of Autoimmune Encephalitis. ➨ 64 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍㸬 2022.6.2
ࠥ4 (6.2). 㧗ᓮ

5.

బஂ㛫ၨ㸬㞴἞㢖ᅇ㒊ศⓎస㔜✚ᆺᛴᛶ⬻⅖ࡢ᭱᪂᝟ሗ㸬ࢩ࣏ࣥࢪ࣒࢘ࠕᑠඣᛴᛶ⬻⑕
up-to-dateࠖ㸬➨ 64 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍㸬

6.

2022.6.2ࠥ4 (6.4). 㧗ᓮబஂ㛫ၨࠊ㜿㒊⿱୍ࠊᒣᙧᓫ೔ࠊᑠ∾ ᏹᩥ㸬⬨㧊ᛶ➽ⴎ⦰⑕ࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥ
ࢢ㸬ࢩ࣏ࣥࢪ࣒࢘ ࠕᣑ኱᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡢᒎᮃ࡜ㄢ㢟㸸᪂つೃ⿵⑌ᝈࡢ࢚ࣅ
ࢹࣥࢫࠖ㸪➨ 125 ᪥ᮏᑠඣ⛉Ꮫ఍Ꮫ⾡㞟఍㸬2022.4.15ࠥ17㸦4.17㸧.Hybrid㸦⚟ᓥ㸧ࡑࡢ௚ 㸦ィ ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1. బஂ㛫ၨ㸬ࠕ࡚ࢇ࠿ࢇ࡜⅖⑕࣭ච␿ࠖ2023.2.22. ᒣ᲍ᑠඣ Epilepsy Education Seminar㸦 eb ㅮ₇㸧

－ 65 －

ࣉࣟࢪ࢙ࢡࢺྡ

⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 0 ௳㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 5 ௳㸧

Shichita T, Ooboshi H, Yoshimura A. Neuroimmune mechanisms mediating post-ischemic brain
injury and repair. Nat Rev Neurosci. (2023) doi: 10.1038/s41583-023-00690-0

2.

Koyama R, Shichita T. Glial roles in sterile inflammation after ischemic stroke. Neurosci Res.
187:67-71 (2023)

3.

Sakai S, Shichita T. Role of alarmins in poststroke inflammation and neuronal repair. Semin
Immunopathol. (2022) doi: 10.1007/s00281-022-00961-54.

୐⏣ᓫ 㸸⬻ ⾑ ⟶ 㞀ᐖ࡜ ⅖ ⑕ ⣽ ⬊㸬 ᭱ ᪂ ⮫ᗋ⬻ ༞ ୰ Ꮫ ➨ 2 ∧ ୗᕳ ᪥ ᮏ ⮫ ∠ ቑ ห

80(2):668-672 (2022)5.

୰ᮧᮒ㔛ࠊ୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⚄⤒⣽⬊Ṛࡢㄏᑟᶵᵓ

་Ꮫࡢ࠶ࡺࡳ

283(5):506-510 (2022)

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧1.

୐⏣ᓫ㸸⬻᱾ሰᚋࡢ⚄⤒ಟ᚟ࢆಁ㐍ࡉࡏࡿ἞⒪ᡓ␎Ꮫ఍ྡ㸸➨ 48 ᅇ᪥ᮏ⬻༞୰Ꮫ఍Ꮫ⾡㞟఍ ሙᡤ㸸ࣃࢩࣇ࢕ࢥᶓ὾ ᖺ᭶㸸2023 ᖺ 3/16 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ₇㸧
2.

Takashi Shichita㸸Lipid metabolism triggering neural repair in brain ischemia. Ꮫ఍ྡ㸸➨ 51
ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍ ሙᡤ㸸⇃ᮏᇛ࣮࣍ࣝ ᖺ᭶㸸2022 ᖺ 12/8 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ
₇㸧

3.

୐⏣

ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⚄⤒ಟ᚟ࡢ࣓࢝ࢽࢬ࣒ Ꮫ఍ྡ㸸➨ 65 ᅇ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍ሙᡤ㸸⏥ᗓグᛕ᪥࣍ࢸࣝ ᖺ᭶㸸2022 ᖺ 10/29 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ₇㸧4.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕࡜⚄⤒ಟ᚟ࡢ㛤ጞ࣓࢝ࢽࢬ࣒

－ 66 －

Ꮫ఍ྡ㸸➨ 40 ᅇ᪥ᮏࣄࢺ

⣽⬊Ꮫ఍ ሙᡤ㸸኱㜰 CIVI ◊ಟࢭࣥࢱ࣮ ᖺ᭶㸸2022 ᖺ 10/22 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ₇㸧
5.

ᓫ㸸Molecular mechanisms initiating sterile inflammation and neural repair after ischemic୐⏣

stroke. Ꮫ఍ྡ㸸➨ 7 ᅇ Diabetes Research Innovation Symposium ሙᡤ㸸ᮾிࣄࣝࢺࣥ࠾ྎ
ሙ
6.

ᖺ᭶㸸2022 ᖺ 7/10 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ₇㸧୐⏣఍ᓫ㸸⬻᱾ሰᚋ࡟࠾ࡅࡿ⅖⑕࡜ಟ᚟ࡢ㛤ጞ࣓࢝ࢽࢬ࣒ Ꮫ఍ྡ㸸➨ 63 ᅇ᪥ᮏ⚄⤒Ꮫሙᡤ㸸ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ ᖺ᭶㸸2022 ᖺ 5/19 ཱྀ㢌Ⓨ⾲㸦ᣍᚅㅮ₇㸧ࡑࡢ௚ 㸦ィ 9 ௳㸧⮬⏤ᥖ㍕
1.

ὠᒣ῟: Role of innate myeloid in functional recovery after ischemic stroke. Ꮫ఍ྡ: ➨ 51 ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍ ሙᡤ: ⇃ᮏᇛ࣮࣍ࣝ ᖺ᭶: 2022 ᖺ 12/8 ࣏ࢫࢱ࣮Ⓨ⾲

2.

୰ᮧᖾኴ㑻, ᑠᒣ㱟ᶞ, ୐⏣

ᓫ: Extracellular DJ-1 has an essential role in the induction ofsterile inflammation. Ꮫ఍ྡ: ➨ 51 ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍ ሙᡤ: ⇃ᮏᇛ࣮࣍ࣝ ᖺ᭶:
2022 ᖺ 12/8 ࣏ࢫࢱ࣮Ⓨ⾲
3.

Sakai S, Ishiwatari R, Yogiashi Y, Shichita T. Functional connectivity is enhanced sensorimotor
cortex after ischemic stroke.Ꮫ఍ྡ㸸Neuroscience 2022

ሙᡤ㸸San Diego, USA ᖺ᭶㸸2022

ᖺ 11/15 ࣏ࢫࢱ࣮Ⓨ⾲
4.

Nakamura K, Sakai S, Tsuyama J, Shichita T㸸Extracellular DJ-1 Induces Sterile Inflammation In
Ischemic Brain Ꮫ఍ྡ㸸Neuroscience 2022 ሙᡤ㸸San Diego, USA ᖺ᭶㸸2022 ᖺ 11/15

࣏

ࢫࢱ࣮Ⓨ⾲
5.

୰ᮧᮒ㔛, 㓇஭ㄔ୍㑻, ᮧୖㄔ, ୐⏣ᓫ: ⬻᱾ሰᚋࡢᶵ⬟ᅇ᚟ࢆಁ㐍ࡍࡿ⏕⌮άᛶ⬡㉁ࡢྠᐃ Ꮫ఍ྡ: ➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ሙᡤ: ྡྂᒇᅜ㝿఍㆟ሙ ᖺ᭶: 2022 ᖺ 11/11
ཱྀ㢌Ⓨ⾲࣭࣏ࢫࢱ࣮Ⓨ⾲
6.

୰ᮧᮒ㔛: ⬡㉁௦ㅰ࡟ࡼࡗ࡚㛤ጞࡉࢀࡿ⬻⮬ᚊⓗ࡞ᶵ⬟ᅇ᚟࣓࢝ࢽࢬ࣒ Ꮫ఍ྡ: ➨ 65 ᅇ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍Ꮫ⾡㞟఍ ሙᡤ: ⏥ᗓグᛕ᪥࣍ࢸࣝ ᖺ᭶: 2022 ᖺ 10/28 ཱྀ㢌Ⓨ⾲(≉ู௻⏬)

7.

୰ᮧᮒ㔛: ⚄⤒⣽⬊࡟࠾ࡅࡿ Padi4 ࡢⓎ⌧ࡣ⬻᱾ሰᚋࡢᶵ⬟ᅇ᚟ࢆಁ㐍ࡍࡿ ఍㆟ྡ:AMED ௧࿴ 4 ᖺᗘ 㐺ᛂ࣭ಟ᚟㡿ᇦⱝᡭ୺యࡢ఍㆟

ሙᡤ: 㛗ᓮฟᓥ࣓ࢵࢭ ᖺ᭶: 2022

ᖺ 10/3 ཱྀ㢌Ⓨ⾲
8.

Nakamura A, Sakai S, Murakami M, Shichita T: The identification of neuro-reparative lipids inischemic stroke, Ꮫ఍ྡ: Brain 2022 ሙᡤ㸸Glasgow ᖺ᭶㸸2022 ᖺ 6 ᭶ 1 ᪥ ࣏ࢫࢱ࣮Ⓨ⾲

9.

Nakamura K, Sakai S, Tsuyama J, Shichita T㸸Extracellular DJ-1 plays a pivotal role in the
induction of sterile inflammation after ischemic stroke Ꮫ఍ྡ㸸BRAINᡤ㸸Glasgow, Scotland ᖺ᭶㸸2022 ᖺ 5/30 ࣏ࢫࢱ࣮Ⓨ⾲－ 67 －BRAIN PET 2022 ሙ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯≉チ⏦ㄳ࣭Ⓨ᫂ࡢྡ⛠㸸⬻ᦆയࡢ἞⒪⏝ࡢ་⸆⤌ᡂ≀ฟ㢪␒ྕ㸸2023-44551Ⓨ᫂⪅࣭ฟ㢪ே㸸ὠᒣ ῟ࠊ୐⏣ ᓫฟ㢪᪥㸸2023 ᖺ 3 ᭶ 27 ᪥

－6 －ࣉࣟࢪ࢙ࢡࢺྡ

⬻⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 3 ௳㸧
1. Hirai S, Miwa H, Shimbo H, Nakajima K, Kondo M, Tanaka T, Ohtaka-Maruyama C, Hirai S,
Okado H.

The mouse model of intellectual disability by BTB18/RP58 haploinsufficiency shows

cognitive dysfunction with synaptic impairment.

ol Psychiatry, 2023 Feb 1.

doi:10.1038/s41380-023-01941-3. Online ahead of print.
2. Hisako Takigawa-Imamura, Saito Hirano, Chisato

atanabe, Chiaki Ohtaka- Maruyama,

Masatsugu Ema, Ken-Ichi Mizutani. Computational Model Exploring Characteristic Pattern
Regulation in Periventricular Vessels. Life (Basel, Switzerland)., 12, 12: 20221209.
doi.org/10.3390/life12122069
3. Noe Kaneko, Kumiko Hirai, Minori Oshima, Kei Yura, Mitsuharu Hattori, Nobuaki Maeda, Chiaki
Ohtaka-Maruyama. ADAMTS2 regulates radial neuronal migration by activating TGF-ȕVLJQDOLQJ
at the subplate layer of the developing neocortex. bioRxiv (2022) 2022.08.07.502954
doi.org/10.1101/2022.08.07.502954

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼
1.

㸦1 ௳㸧

Takuma Kumamoto, Chiaki Ohtaka-Maruyama. Visualizing Cortical Development and Evolution:
A Toolkit Update. Frontiers in neuroscience., 16, 876406-876406, 2022.
(doi.org/10.3389/fnins.2022.876406)

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 3 ௳㸧
1. Ohtaka-Maruyama CࠕAnalysis of the developmental and evolutionary origins of SpNs andtheir role in cerebral developmentࠖInternational Symposium on Neural Development andDiseases ᪂Ꮫ⾡㡿ᇦ◊✲ࠕⓎ⏕᫬ィ࡜ሙࡢ㐃ᦠࠖ2023 ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘  2023/3/16 ி㒔኱Ꮫ་Ꮫ㒊Ⱚ⹒఍㤋 ி㒔ᗓ ி㒔ᕷ

－6 －2. Ohtaka-Maruyama C,ࠕIdentification of embryonic molecular markers of mouse subplate

neurons and search for their developmental originsࠖ➨45ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍(NEURO2022)ࠕFormation of the earliest cortical neuronal circuits orchestrated bysubplate neural activityࠖࢩ࣏ࣥࢪ࣒࢘ࠕࢧࣈࣉ࣮ࣞࢺ⚄⤒άືࡢࢲ࢖ࢼ࣑ࢬ࣒࡟ࡼࡿ⬻⚄⤒ᅇ㊰ࡢⓎ㐩ᶵࠖ 2022/6/30 Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮ Ἀ⦖┴ ᐅ㔝‴ᕷ
3. Ohtaka-Maruyama C ࠕRole of subplate neurons in neocortical development and evolutionࠖ
Cortical Development Conference 2022ࠕNeural Stem Cells to Neural

Circuitsࠖ2022/5/30

Milazzo ࢩࢳࣜ࢔ᓥ ࢖ࢱࣜ࢔ࡑࡢ௚ 㸦ィ 24 ௳㸧⮬⏤ᥖ㍕
1.

㝰ඖᣅ㤿 ᪂つࣀࢵࢡ࢖ࣥࣛࢵࢺࠕRtbowࠖࡢᶞ❧࡜ᛂ⏝ࠖ ᅜෆඹྠ฼⏝࣭ඹྠ◊✲ᣐ
Ⅼ஦ᴗ 2022 ᖺᗘᡂᯝሗ࿌఍ 2023/3/13 ᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤ/ᮾி㒔

2.

ᯇᮧὈᏹ Functional analysis of a transcription factor ST18 expressing in human SpNs in mice➨ 16 ᅇ⚄⤒Ⓨ⏕ウㄽ఍ 2023/3/10㹼2023/3/11 ᪩✄⏣኱Ꮫඛ➃⏕࿨་⛉Ꮫࢭࣥࢱ࣮/ᮾி㒔

3.

࿴⏣ி௓ Analysis of neuronal migration pattern in the developing avian brain ➨ 16 ᅇ⚄⤒Ⓨ⏕ウㄽ఍ 2023/3/10㹼2023/3/11 ᪩✄⏣኱Ꮫඛ➃⏕࿨་⛉Ꮫࢭࣥࢱ࣮/ᮾி㒔4.

㔝ᮧ㐶 Induction of SpN cell death in the mouse cerebral cortex using DT and DTR

expression control systems ➨ 16 ᅇ⚄⤒Ⓨ⏕ウㄽ఍ 2023/3/10㹼2023/3/11 ᪩✄⏣኱Ꮫඛ➃⏕࿨་⛉Ꮫࢭࣥࢱ࣮/ᮾி㒔5.

ᮡ⏣♸㍜, ᏲᒇᩗᏊ, ୸ᒣ༓⛅ Subplate neurons decrease subtype-specifically in postnatal
development➨ 16 ᅇ⚄⤒Ⓨ⏕ウㄽ఍ 2023/3/10㹼2023/3/11 ᪩✄⏣኱Ꮫඛ➃⏕࿨་⛉Ꮫࢭࣥࢱ࣮/ᮾி㒔6.

㝰ඖᣅ㤿 㫽㢮኱⬻࡟࠾ࡅࡿࢢࣜ࢔⣽⬊⏘⏕࣓࢝ࢽࢬ࣒ࡢゎᯒ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ 2022 ᖺᗘᡂᯝⓎ⾲఍ 2023/2/8㹼2023/2/9 ⍇⍈†࣍ࢸࣝ/⁠㈡┴኱ὠᕷ7.

୸ᒣ༓⛅ Visium ✵㛫㑇ఏᏊゎᯒࢆ⏝࠸࡚኱⬻⓶㉁ࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢᮇ㝈ࢆ᥈ࡿ2022 ᖺᗘࠕඛ㐍ࢤࣀ࣒ᨭ᥼ࠖᣑ኱⌜఍㆟ 2023/1/19㹼2023/1/20 ࣃࢩࣇ࢕ࢥᶓ὾/⚄ዉᕝ┴ᶓ὾ᕷ
8.

㝰ඖᣅ㤿 Ⓨ⏕ᮇࡢࢽ࣡ࢺࣜ኱⬻࡟࠾ࡅࡿࢢࣜ࢔⣽⬊Ⓨ⌧ᵝᘧ 2022 ᖺᗘࠕඛ㐍ࢤࣀ࣒ᨭ᥼ࠖᣑ኱⌜఍㆟

9.

2023/1/19㹼2023/1/20 ࣃࢩࣇ࢕ࢥᶓ὾/⚄ዉᕝ┴ᶓ὾ᕷ㜿▱Ἴࡦ࡜ࡳ, ᳃ᒸṌክ, 㝰ඖᣅ㤿, ཎ㞝୍㑻, ᕝ㊰ⱥဢ, ከ㈡ཝኴ㑻, ୸ᒣ༓⛅ ࢩࣥࢢࣝࢭࣝ RNAseq ࡟ࡼࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥⓎ⌧㑇ఏᏊࡢྠᐃ ᪩ᮇࣛ࢖ࣇ㡿ᇦ௧࿴ 5ᖺᗘ㡿ᇦ఍㆟ 2022/12/22㹼2022/12/24 ࣇࢡࣛࢩ࢔ရᕝࢡࣜࢫࢱࣝ/ᮾி㒔－7 －10. ୸ᒣ༓⛅, ྜྷᮧ⏤⨾Ꮚ, ᇛᡤ༤அ,ከ㈡ཝኴ㑻 ࢧࣈࣉ࣮ࣞࢺ⚄⤒άືࡢࢲ࢖ࢼ࣑ࢬ

࣒࡟ࡼࡿ⬻⚄⤒ᅇ㊰ࡢⓎ㐩ᶵᵓ ᪩ᮇࣛ࢖ࣇ㡿ᇦ௧࿴ 4 ᖺᗘ㡿ᇦ఍㆟
2022/12/24

2022/12/22㹼

ࣇࢡࣛࢩ࢔ရᕝࢡࣜࢫࢱࣝ/ᮾி㒔

11. ᯇᮧὈᏹ ࣄࢺ࡜࣐࢘ࢫ࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺ࣐࣮࣮࢝㑇ఏᏊࡢẚ㍑ゎᯒ ᪩ᮇࣛ࢖ࣇ
㡿ᇦ௧࿴ 4 ᖺᗘ㡿ᇦ఍㆟ 2022/12/22㹼2022/12/24 ࣇࢡࣛࢩ࢔ရᕝࢡࣜࢫࢱࣝ/ᮾி㒔
12. 㔝ᮧ㐶 ࢪࣇࢸࣜ࢔ẘ⣲㸦DT㸧࡜ࡑࡢཷᐜయ㸦DTR㸧ࡢⓎ⌧ไᚚ⣔ࢆ⏝࠸ࡓࢧࣈࣉࣞ

࣮ࢺࢽ࣮ࣗࣟࣥ㸦SpN㸧ࡢ⣽⬊Ṛㄏᑟ ᪩ᮇࣛ࢖ࣇ㡿ᇦ௧࿴ 4 ᖺᗘ㡿ᇦ఍㆟ 2022/12/22
㹼2022/12/24

ࣇࢡࣛࢩ࢔ရᕝࢡࣜࢫࢱࣝ/ᮾி㒔

13. 㔝ཱྀ཭⌮ె ့ங㢮኱⬻⓶㉁ᙧᡂ࡟㔜せ࡞ᶵ⬟ࢆᯝࡓࡍࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢⓎ⏕㉳※᪩ᮇࣛ࢖ࣇ㡿ᇦ௧࿴ 4 ᖺᗘ㡿ᇦ఍㆟ 2022/12/22㹼2022/12/24 ࣇࢡࣛࢩ࢔ရᕝࢡ

ࣜࢫࢱࣝ/ᮾி㒔
14. ᮡ⏣♸㍜ ࣐࢘ࢫࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢ⏕ᚋⓎ㐩㐣⛬࡟࠾ࡅࡿᣲື ᪩ᮇࣛ࢖ࣇ㡿ᇦ௧࿴ 4 ᖺᗘ㡿ᇦ఍㆟ 2022/12/22㹼2022/12/24 ࣇࢡࣛࢩ࢔ရᕝࢡࣜࢫࢱࣝ/ᮾி㒔
15. 㔝ཱྀ཭⌮ె, 㜿▱Ἴࡦ࡜ࡳ, 㝰ඖᣅ㤿, ୸ᒣ༓⛅ ࢺࣛࣥࢫࢡࣜࣉࢺ࣮࣒ࢹ࣮ࢱゎᯒ࡛᥈ࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢⓎ⏕㉳※ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼
2022/12/2

ᖥᙇ࣓ࢵࢭ/༓ⴥ┴16. ᮡ⏣♸㍜, ᏲᒇᩗᏊ, 㧗ᶫῄᏊ, ୸ᒣ༓⛅ ⏕ᚋⓎ⏕㐣⛬࡟࠾ࡅࡿ࣐࢘ࢫࢧࣈࣉ࣮ࣞࢺࢽ
࣮ࣗࣟࣥࡢᣲື ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴17. 㝰ඖᣅ㤿 Development and evolutional origin of subplate neurons
Olasticity of the Brain 2022/10/21㹼2022/10/23

Hotel

Development andResorts ISE/୕㔜┴ᚿᦶᕷ18. 㜿▱Ἴࡦ࡜ࡳ, ᳃ᒸṌክ, 㝰ඖᣅ㤿, ཎ㞝୍㑻, ᕝ㊰ⱥဢ, ከ㈡ཝኴ㑻, ୸ᒣ༓⛅ ࢩࣥࢢࣝࢭࣝ RNA ゎᯒ࡟ࡼࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢࢧࣈࢱ࢖ࣉྠᐃ

ࢩࣥࢢࣝࢭࣝࢤࣀ࣑

ࢡࢫ 2022 2022/8/30㹼2022/8/31 ࡳࡸࡇࡵࡗࡏ/ி㒔ᕷ
19. ୸ᒣ༓⛅ Identification of embryonic molecular markers of mouse subplate neurons and search
for their developmental origins ࢧࣈࣉ࣮ࣞࢺ⚄⤒άືࡢࢲ࢖ࢼ࣑ࢬ࣒࡟ࡼࡿ⬻⚄⤒ᅇ㊰ࡢⓎ㐩ᶵᵓ NEURO2022 ➨ 45 ᅇ ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/29㹼2022/7/3 Ἀ⦖ࢥࣥ࣋ࣥࢩ
ࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ
20. 㝰ඖᣅ㤿, Ᏽ⚈㉪,୸ᒣ༓⛅ Ⓨ⏕ᮇࡢࢽ࣡ࢺࣜ኱⬻࡟࠾ࡅࡿࢢࣜ࢔⣽⬊Ⓨ⌧ᵝᘧ

NEURO2022 ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/30㹼2022/7/3

Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥ

ࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ
21. ᏲᒇᩗᏊ Dynamics of Subplate neurons in postnatal development NEURO2022 ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/29㹼2022/7/3 Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ

－ 71 －

22. 㔝ཱྀ཭⌮ె, 㝰ඖᣅ㤿, ୸ᒣ༓⛅ ့ங㢮኱⬻⓶㉁࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢⓎ⏕㉳※ NEURO2022 ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2022/6/29㹼2022/7/3 Ἀ⦖ࢥࣥ࣋ࣥࢩ
ࣙࣥࢭࣥࢱ࣮௚/Ἀ⦖┴ᐅ㔝‴ᕷ
23. ୸ᒣ༓⛅ Role of subplate cells in neocortical development and evolutioniOn switch is a novel
lineage tracing tool in the chick cortex
Cells to Neural Circuits

Cortical Development Conference 2022 Neural Stem

2022/5/28㹼2022/6/3 Milazzo, Sicily, Italy

24. 㜿▱Ἴࡦ࡜ࡳ, 㝰ඖᣅ㤿, ཎ㞝୍㑻, ᕝ㊰ⱥဢ, ୸ᒣ༓⛅ Identification of marker genes inembryonic subplate neurons by single-cell analysis

Cortical Development Conference 2022

Neural Stem Cells to Neural Circuits 2022/5/28㹼2022/6/3 Milazzo, Sicily, Italy

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧
1.

୸ᒣ༓⛅⫾ඣᮇ࠿ࡽࡢ⬻Ⓨ㐩࡟ᶵ⬟ࡍࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢᙺ๭ࠖ ➨  ᅇᮾி
2023/3/13 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤㅮᇽ࡜࢜ࣥࣛ

㒔❧⑓㝔ᶵᵓ➼࡜ࡢ㐃ᦠ◊✲ࢭ࣑ࢼ࣮࢖ࣥࡢࣁ࢖ࣈࣜࢵࢻ
2.

୸ᒣ༓⛅ ࠕ⬻Ⓨ⏕Ꮫ◊✲࡟ࡓ࡝ࡾ╔ࡃࡲ࡛ࠖዪᛶ་⒪ே࢟ࣕࣜ࢔ᙧᡂࢭࣥࢱ࣮୺ദ ࣆ࢔࣮ࣛࢽࣥࢢ for ࡸࡼ࠸ࡧ࡜㸦➨ 3 ᅇ㸧ㅮ₇఍ 2023/2/22㸦࢜ࣥࣛ࢖ࣥ㸧

3.

୸ᒣ༓⛅ ࠕࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢ⚄⤒άື࡟ࡼࡿ኱⬻᪂⓶㉁ᵓ⠏ࡢ࣓࢝ࢽࢬ࣒ࠖ
2022/9/13 ྠᚿ♫኱Ꮫ⬻⛉Ꮫ◊✲⛉ 2022 ࣜࢺ࣮ࣜࢺㅮ₇఍ ྠᚿ♫኱Ꮫ ி⏣㎶࢟ࣕࣥࣃࢫ ᜨ㐨㤋 201 ி㒔ᗓ ி⏣㎶ᕷ

4.

୸ᒣ༓⛅ࠕ⬻ࡀ࡛ࡁࡿ᫬ࠊቯࢀࡿ᫬ࠖ 2022/4/26௧࿴  ᖺᗘ᫫ᱜ఍⥲఍ㅮ₇఍㸦࢜ࣥࣛ࢖ࣥ㓄ಙ㸧IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

୸ᒣ༓⛅ ᪂₲኱Ꮫ኱Ꮫ㝔་ṑᏛ ་⛉Ꮫᑓᨷ࣭⬻࣭⚄⤒⛉Ꮫ◊✲ศ㔝㸦ಟኈㄢ⛬㸧ᐈဨᩍဨ

2.

2022.10.01-2023.03.31

୸ᒣ༓⛅ ᪂₲኱Ꮫ኱Ꮫ㝔་ṑᏛ ศᏊ⣽⬊་Ꮫᑓᨷ࣭⬻࣭⚄⤒⛉Ꮫ◊✲ศ㔝㸦༤ኈㄢ⛬㸧ᐈဨᩍဨ 2022.10.01-2023.03.31

3.

୸ᒣ༓⛅ ᮾி㒔❧኱Ꮫ ᐈဨ෸ᩍᤵ 2022.04.01-2023.03.31

4 ୸ᒣ༓⛅ ࠾ⲔࡢỈዪᏊ኱Ꮫ ኱Ꮫ㝔ே㛫ᩥ໬๰ᡂ⛉Ꮫ◊✲⛉
2022.04.01-2024.03.31

－7 －

ᐈဨ෸ᩍᤵ

5.

⚄ᮧᆂு ᪥ᮏ኱Ꮫᩥ⌮Ꮫ㒊㠀ᖖ໅ㅮᖌ

6.

⚄ᮧᆂு

7.

ᏲᒇᩗᏊ ኱ጔዪᏊ኱Ꮫከᦶᰯ 㠀ᖖ໅ㅮᖌ ඲Ꮫඹ㏻⛉┠ࠗ⏕άࡢ໬Ꮫ࠘ᚋᮇ㏻ᖺ

8.

ᏲᒇᩗᏊ ᫂ᾏ኱ᏛṑᏛ㒊 㠀ᖖ໅ㅮᖌ

9.

ᏲᒇᩗᏊ ᪥ᮏ⋇་⏕࿨⛉Ꮫ኱Ꮫ኱Ꮫ㝔 ⋇་Ꮫᑓᨷ༤ኈㄢ⛬≉ูㅮ⩏  ㅮ⩏ᒸᒣ኱Ꮫ་Ꮫ㒊㠀ᖖ໅ㅮᖌ

2022.04.01-2023.03.31
2022.04.01-2023.03.31

ࠗ⏕⌮Ꮫᐇ⩦࠘๓ᮇ㞟୰࠙♫఍࣭ᬑཬάືࠚ
1.

୸ᒣ༓⛅ 㒔་Ꮫ◊ኟࡢࢭ࣑ࢼ࣮ ࠕ⚄⤒⣽⬊ࢆྍど໬ࡋ࡚኱⬻᪂⓶㉁ࡢᒙᵓ㐀ࡢࡾ❧ࡕࢆ᥈ࡿࠖ  ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤᮾி㒔

2.

୸ᒣ༓⛅ ᪥ᮏ⏕⌮Ꮫ఍ ⏕⌮Ꮫዪᛶ◊✲⪅ࡢ఍ :3- ௻⏬ጤဨ

3.

୸ᒣ༓⛅ ᩥ㒊⛉Ꮫ┬ ⛉Ꮫᢏ⾡࣭Ꮫ⾡ᨻ⟇◊✲ᡤ ⛉Ꮫᢏ⾡ண

4.

୸ᒣ༓⛅ ᪥ᮏᏛ⾡᣺⯆఍≉ู◊✲ဨ➼ᑂᰝ఍ᑓ㛛ጤဨ

5.

୸ᒣ༓⛅ ⛉Ꮫ◊✲㈝ጤဨ఍ᑓ㛛ጤဨ㸦ᑂᰝ࣭ホ౯➨஧㒊఍㸧6.

୸ᒣ༓⛅ Dana Alliance Brain Initiative (DABI) ጤဨ

7.

୸ᒣ༓⛅ ࠕNeuroscience Research ࠖAssociate Editor8.

୸ᒣ༓⛅ ࠕCellsࠖGuest Editor

9.

⚄ᮧᆂு ࣉࣟࢸ࢜ࢢࣜ࢝ࣥࣇ࢛࣮࣒ࣛୡヰே࡜ࡋ࡚ࣉࣟࢸ࢜ࢢࣜ࢝ࣥ◊✲ࡢ఍㆟㛤ദ
ࡢ㐠Ⴀ

－7 －

ࢭࣥࢱ࣮ ᑓ㛛ㄪᰝဨࣉࣟࢪ࢙ࢡࢺྡ

⤫ྜኻㄪ⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 15 ௳㸧
1.

Tomita Y, Suzuki K, Yamasaki S, Toriumi K, Miyashita M, Ando S, Endo K, Yoshikawa A,
Tabata K, Usami S, Hiraiwa-Hasegawa M, Itokawa M, Kawaji H, Kasai K, Nishida A, Arai M.
Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences.
Schizophrenia (Heidelb). 2023 Mar 11 9(1):14. doi: 10.1038/s41537-023-00340-5.

2.

Kirihara K, Fujioka M, Suga M, Kondo S, Ichihashi K, Koshiyama D, Morita K, Ikegame T, Tada
M, Araki T, Jinde S, Taniguchi K, Hosokawa T, Sugishita K, Dogan S, Marumo K, Itokawa M,
Kasai K. Betaine supplementation improves positive symptoms in schizophrenia. Schizophr Res.
2022 Dec 250:120-122. doi: 10.1016/j.schres.2022.11.009.

3.

Tabata K, Miyashita M, Yamasaki S, Toriumi K, Ando S, Suzuki K, Endo K, Morimoto Y,
Tomita Y, Yamaguchi S, Usami S, Itokawa M, Hiraiwa-Hasegawa M, Takahashi H, Kasai K,
Nishida A, Arai M. Hair zinc levels and psychosis risk among adolescents. Schizophrenia(Heidelb). 2022 Nov 25 8(1):107. doi: 10.1038/s41537-022-00307-y.

4.

Koike S, Miyaji Y, Suzuki K, Miyashita M, Itokawa M, Arai M, Ogasawara Y.
Plasma unconjugated bile acids as novel biomarker for schizophrenia.
Biochem Biophys Res Commun. 2022 Oct 4 634:70-74. doi:10.1016/j.bbrc.2022.09.110.

5.

Inoue T, Shinba T, Itokawa M, Sun G, Nishikawa M, Miyashita M, Suzuki K, Kariya N, Arai M,
Matsui T. The development and clinical application of a novel schizophrenia screening systemusing yoga-induced autonomic nervous system responses. Front Physiol. 2022 Oct 5 13:902979.
doi:10.3389/fphys.2022.902979.

6.

Ishida H, Miyashita M, Oshima K, Kawakami I, Sekiyama K, Kounoe M, Seki E, Arai N,
Takizawa S, Nagata E, Itokawa M, Arai M. Carbonyl stress-sensitive brain regions in the patientwith treatment-resistant schizophrenia with a glyoxalase 1 frameshift mutation: Autopsy study.
Psychiatry Research Case Reports. . 1(2) Dec. 100064, 2022.
https://doi.org/10.1016/j.psycr.2022.100064

7.

Kushima I, Aleksic B, Kimura H, Nakatochi M, Lo T, Ikeda M, Arai M, Hashimoto R, Numata S,
Okamura Y, Obara T, Inada T, Ozaki N.

chromosome aneuploidies and schizophrenia:－7 －association analysis and phenotypic characterization. Psychiatry Clin Neurosci. 2022
Dec 76(12):667-673. doi: 10.1111/pcn.13474.
8.

Yoshikawa A, Kushima I, Miyashita M, Suzuki K, Iino K, Toriumi K, Horiuchi Y, Kawaji H,
Ozaki N, Itokawa M, Arai M. Exonic deletions in IMMP2L in schizophrenia with enhanced
glycation stress subtype. PLoS One. 2022 Jul 1 17(7):e0270506. doi:
10.1371/journal.pone.0270506.

9.

Ishiguro H, Kibret BG, Horiuchi Y, Onaivi ES. Potential Role of Cannabinoid Type 2 Receptors in
Neuropsychiatric and Neurodegenerative Disorders. Front Psychiatry. 2022 Jun 14 13:828895.
doi: 10.3389/fpsyt.2022.828895.

10. Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka
K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y,
Ogawa N, Iritani S, Hayashi Y, Lo T, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T,
Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M,
Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T,

atanabe Y, Egawa J,

Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H,
Kato TA, Kanba S, Horikawa H, Usami M, Kodaira M,

akuda T,

atanabe K, Yoshikawa T, Toyota T,

Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung M, Kasai K, Ikegame T, Jinde
S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa
S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto YI, Okumura Y, Ito T,
Arioka Y, Mori D, Ozaki N. Cross-Disorder Analysis of Genic and Regulatory Copy Number
Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder. Biol Psychiatry.
2022 Apr 22:S0006-3223(22)01197-0. doi: 10.1016/j.biopsych.2022.04.003.
11. Ruan Y, Lin YF, Feng YA, Chen CY, Lam M, Guo

Stanley Global Asia Initiatives, He L, Sawa

A, Martin AR, in S, Huang H, Ge T. Improving polygenic prediction in ancestrally diverse
populations. Nat Genet. 2022 May 54(5):573-580. doi: 10.1038/s41588-022-01054-7.
12. Toriumi K,

ang G , Berto S, Usui N. Editorial: Decoding Brain Function Through Genetics.

Front Genet., 202204.
13. Suzuki K, Yamasaki S, Miyashita M, Ando S, Toriumi K, Yoshikawa A, Nakanishi M, Morimoto
Y, Kanata S, Fujikawa S, Endo K, Koike S, Usami S, Itokawa M,

ashizuka S, Hiraiwa-

Hasegawai M, Herbert Meltzer H, Kasai K, Nishida A, Arai M. Role of advanced glycation end
products in the longitudinal association between muscular strength and psychotic symptoms
among adolescents. Schizophr 8, 44 (2022). https://doi.org/10.1038/s41537-022-00249-5
14. Mizutani R, Noguchi S, Saiga R, Yamashita Y, Miyashita M, Arai M, Itokawa M. SchizophreniaMimicking Layers Outperform Conventional Neural Network Layers. Front Neurorobot. 2022
Mar 28 16:851471. doi: 10.3389/fnbot.2022.851471.

－ 75 －

15. Suzuki M, Inoue KI, Nakagawa H, Ishida H, Kobayashi K, Isa T, Takada M, Nishimura Y. A
multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. J
Physiol. 2022 Apr 600(7):1731-1752. doi: 10.1113/JP282429.
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 5 ௳㸧

1. 㫽ᾏ࿴ஓࠊ⏣⏿ග୍ࠊ⋤ᜣ෈ࠊᮅ಴⯙ࠊᐑୗගᘯࠊ᪂஭ㄔ㠀㓝⣲ⓗ⢾໬཯ᛂ㸦࣓࢖࣮ࣛࢻ཯ᛂ㸧ࡢ⑌ᝈ࡟࠾ࡅࡿᙺ๭࡜௒ᚋࡢᒎᮃ㸦3㸧࢝ࣝ࣎ࢽࣝࢫࢺࣞࢫ࡜⢭⚄⑌ᝈ

BioClinica 37 (10): 28-33, 2022.
2. Toriumi K, Miyashita M, Suzuki K, Tabata K, Horiuchi Y, Ishida H, Itokawa M, Arai
M. Role of glyoxalase 1 in methylglyoxal detoxification-the broad player of psychiatricdisorders. Redox Biol. 2022 Feb;49:102222. doi: 10.1016/j.redox.2021.102222.1.
3. ⣒ᕝᫀᡂ≉㞟 6࣭࠶ࡁࡽࡵࡀᝏ࠸࣓ࣥࢱࣝ࣊ࣝࢫ࣐࢞ࢪࣥࡇࡇࢁࡢඖẼ plus 181:1617 2022
4. ⣒ᕝᫀᡂ⢭⚄་Ꮫ࡟࠾ࡅࡿ⑕౛ሗ࿌ࡢព⩏⮫ᗋ⢭⚄་Ꮫ 51(2): 133-137, 2022
5. ⃝᫂ᇼෆὈỤ᪂஭ㄔᵽཱྀ㍤ᙪ⣒ᕝᫀᡂࠕ⢭⚄⑌ᝈࢤࣀ࣒◊✲ᅜ㝿ࢥࣥࢯ࣮ࢩ࢔
࣒ࠖࡢࡈ⤂௓2014 ᖺ࠿ࡽࡢ㌶㊧ᐇ㦂་Ꮫ 40(1):63-65, 2022.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 25 ௳㸧⮬⏤ᥖ㍕
1.

▼⏣⿱᫛ࠊᐑୗගᘯࠊ኱ᓥ೺୍ࠊ Ἑୖ⥴ࠊ 㛵ᒣ୍ᡂࠊ 㬨Ụ┿⥔ࠊ 㛵⤮㔛㤶ࠊ ᪂஭ಙ㝯ࠊ℧⃝ಇஓࠊỌ⏣ᰤ୍㑻ࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬៏ᛶᮇ⤫ྜኻㄪ⑕ᝈ⪅ࡢṚᚋ⬻࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ⵳✚㸬➨  ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍㹙2023/3/25㹛 㸦ཱྀ㢌Ⓨ⾲㸧WEB 㛤ദ2.

᪂஭ㄔࠊ ụ⃝⪽㸬୍⯡₇㢟ࢭࢵࢩࣙࣥ I-1-4㸬➨ 17 ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍
㹙2023/3/26㹛㸦ᗙ㛗㸧WEB 㛤ദ

3.

㫽ᾏ࿴ஓࠊᑠụఙࠊẁᏕࠊ㕥ᮌ୍ᾈࠊᐑୗගᘯࠊᇼෆὈỤࠊᑠ➟ཎ⿱ᶞࠊᐑ⏣ᩄ⏨ࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝゎẘ㞀ᐖ࡟ࡼࡿ⤫ྜኻㄪᵝ⾜ື␗ᖖⓎ⌧ࡢศᏊᶵᗎゎ᫂ ➨ 96 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍ [2022/11/30㹼2022/12/3]
ᕝ┴ᶓ὾ᕷ－ 76 －

ࣃࢩࣇ࢕ࢥᶓ὾⚄ዉ

4.

㫽ᾏ࿴ஓࠊ㣤㔝㡪ḷࠊᑠ⃝᭷㒔⳯ࠊᐑୗගᘯࠊ㕥ᮌ୍ᾈࠊ⏣⏿ග୍ࠊ⣒ᕝᫀᡂࠊỌ஭❳ඣࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟㛵㐃ࡋࡓ᪂つ࣌ࣥࢺࢩࢪࣥྜᡂ⤒㊰ࡢྠᐃ㸬➨ 32 ᅇ᪥ᮏ࣓࢖
࣮ࣛࢻᏛ఍ 㹙2022/11/12㹛㸦ཱྀ㢌Ⓨ⾲㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ

5.

▼⏣⿱᫛ࠊᐑୗගᘯࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕⢾໬ࢫࢺࣞࢫ⑓ែࡣ๓㢌ⴥѸ኱⬻ᇶᗏ᰾Ѹᑠ⬻ࡀ㛵୚ࡍࡿ࠿㸽Ѹ⤫ྜኻㄪ⑕ᝈ⪅Ṛᚋ⬻࡜㠀ࣄࢺ㟋㛗㢮ࣔࢹࣝ◊✲Ѹ㸬➨ 32 ᅇ᪥ᮏ࣓࢖ࣛ
࣮ࢻᏛ఍ 㹙2022/11/12㹛㸦ཱྀ㢌Ⓨ⾲㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ

6.

⋤ᜣ෈㸪㫽ᾏ࿴ஓࠊ 㕥ᮌ୍ᾈࠊ ⣒ᕝᫀᡂࠊ ᪂஭ㄔ㸬⫾ඣᮇ࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝ᭚㟢ࡀᡂయᮇ࣐࢘ࢫࡢ⾜ື࡜⚄⤒ఏ㐩⣔࡟୚࠼ࡿ㛗ᮇⓗ࡞ᙳ㡪㸬➨ 32 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍
㹙2022/11/12㹛㸦࣏ࢫࢱ࣮Ⓨ⾲࣭ඃ⚽࣏ࢫࢱ࣮㈹㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ7.

ᮅ಴⯙ࠊ㫽ᾏ࿴ஓࠊ㔝ᓮ⥤ࠊ᳿㔠⦋ࠊ❧ᓮோࠊ᪂஭ㄔ㸬᪂つྜᡂ⤒㊰࡟ᇶ࡙ࡃ࣌ࣥࢺࢩ
ࢪࣥྜᡂ㜼ᐖ๣ࡢ᥈⣴㸬➨  ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 㹙2022/11/12㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ8.

ᑠ⃝᭷㒔⳯ࠊ㫽ᾏ࿴ஓࠊ㐲⸨ᙯ๎ࠊబ఑Ὀࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ
⵳✚⑓ែࡢゎ᫂㸬➨ 32 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 㹙2022/11/12㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ

9.

㣤㔝㡪ḷࠊ㫽ᾏ࿴ஓࠊ᪂஭ㄔ㸬࣌ࣥࢺࢩࢪࣥ⵳✚ᆺ⤫ྜኻㄪ⑕࡟࠾ࡅࡿ AKR1A1 ࡢ㑇ఏᏊゎᯒ㸬➨ 32 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 㹙2022/11/12㹛㸦࣏ࢫࢱ࣮Ⓨ⾲࣭ඃ⚽࣏ࢫࢱ࣮㈹㸧ಟᩥ኱Ꮫ/ឡ▱┴୍ᐑᕷ10. 㣤㔝㡪ḷࠊ㫽ᾏ࿴ஓࠊᮾỤ⍵Ꮚࠊᐑୗගᘯࠊ㕥ᮌ୍ᾈࠊᇼෆὈỤࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ AKR1A1 ᶵ⬟ゎᯒ㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹙2022/11/11㹛㸦ཱྀ㢌࣭࣏ࢫࢱ࣮Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ
11. ⏣⏿ග୍ࠊᐑୗගᘯࠊᒣᓮಟ㐨ࠊ㫽ᾏ࿴ஓࠊᏳ⸨ಇኴ㑻ࠊ㕥ᮌ୍ᾈࠊ㧗ᶫⱥᙪࠊ➟஭Ύ
Ⓩࠊ⣒ᕝᫀᡂࠊす⏣῟ᚿࠊ᪂஭ㄔ㸬ᛮ᫓ᮇ࡟࠾ࡅࡿẟ㧥ள㖄⃰ᗘ࡜⢭⚄⑓Ⓨ⑕ࣜࢫࢡࡢ
㛵㐃㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹙2022/11/9㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㹙2022/11/11㹛㸦ཱྀ㢌Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ12. 㫽ᾏ࿴ஓࠊᑠụఙࠊẁᏕࠊ㕥ᮌ୍ᾈࠊᐑୗගᘯࠊᇼෆὈỤࠊᑠ➟ཎ⿱ᶞࠊᐑ⏣ᩄ⏨ࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝゎẘ㞀ᐖ࡟ࡼࡿ⤫ྜኻㄪ⑕ᵝ⾜ື␗ᖖⓎ⌧ࡢศᏊᶵᗎゎ᫂㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹙2022/11/10㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ
13. ⋤ᜣ෈ࠊ㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊᑠ⃝᭷㒔⳯ࠊṇ⏣┿ౡᏊࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⫾ඣᮇ࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝ᭚㟢ࡀᡂయᮇ࣐࢘ࢫࡢ⾜ື࡜⚄⤒ఏ㐩⣔࡟୚࠼ࡿ㛗ᮇⓗ࡞ᙳ㡪㸬➨95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹙2022/11/9㹛㸦ཱྀ㢌Ⓨ⾲㸧㹙2022/11/10㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ－ 77 －

14. ᮅ಴⯙ࠊ㫽ᾏ࿴ஓࠊ㔝ᓮ⥤ࠊ᳿㔠⦋ࠊ❧ᓮோࠊ㕥ᮌ୍ᾈࠊᐑୗගᘯࠊ⣒ᕝᫀᡂࠊ᪂஭
ㄔ㸬in vitro ୗ࡛ࡢ࣌ࣥࢺࢩࢪࣥྜᡂ㜼ᐖ๣ࡢ᥈⣴㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍
㹙2022/11/10㹛㸦ཱྀ㢌Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ15. ᑠ⃝᭷㒔⳯ࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊᐑୗගᘯࠊ㐲⸨ᙯ๎ࠊబ఑Ὀࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ⵳✚⑓ែࡢゎ᫂㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍
㹙2022/11/9㹛㸦ཱྀ㢌࣭࣏ࢫࢱ࣮Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ
16. ᐩ⏣ᗣᩥࠊ㕥ᮌ୍ᾈࠊ⏣⏿ග୍ࠊᕝ㊰ⱥဢࠊᐑୗගᘯࠊ㫽ᾏ࿴ஓࠊᒣᓮಟ㐨ࠊᏳ⸨ಇኴ
㑻ࠊ➟஭ΎⓏࠊす⏣῟ᚿࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬ᒀ୰࢚࢟ࢯࢯ࣮࣒ྵ᭷ miRNA ࡟ࡼࡿ⢭⚄⑓ᵝయ㦂ࡢᣢ⥆ࡢண 㸬➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹙2022/11/10㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ17. 㕥ᮌ୍ᾈࠊᒣᓮಟ㐨ࠊᐑୗගᘯࠊᏳ⸨ಇኴ㑻ࠊ㫽ᾏ࿴ஓࠊྜྷᕝⲁࠊ୰す୕᫓ࠊ᳃ᮏ⿱
Ꮚࠊ㔠⏣΅ࠊ⸨ᕝៅஓࠊ㐲⸨㤶⧊ࠊᑠụ㐍௓ࠊᏱబ⨾្ࠊ⣒ᕝᫀᡂࠊ㮖ሯఙ௓ࠊ㛗㇂ᕝ┾⌮Ꮚࠊ➟஭ΎⓏࠊす⏣῟ᚿࠊ᪂஭ ㄔ㸬ᛮ᫓ᮇࡢప➽ຊ࡜⢭⚄⑓Ⓨ⑕ࣜࢫࢡࡢ⦪᩿ⓗ㛵㐃࡟࠾ࡅࡿ⢾໬ࢫࢺࣞࢫࡢព⩏㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍ 㹙2022/11/05㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
18. ᑿᓮ⣖ኵࠊ᪂஭ㄔ㸬ࢩ࣏ࣥࢪ࣒࢘ 2㸸⬤ᙅᛶ࡜ࣞࢪ࢚ࣜࣥࢫࡢ⢭⚄⑌ᝈ◊✲̿ྍረᛶࡢ
⬻⛉Ꮫ̿㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍ 㹙2022/11/04㹛㸦ᗙ㛗㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
19. 㫽ᾏ࿴ஓ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ⢾໬ࢫࢺࣞࢫ⵳✚ࡢศᏊᶵᗎ㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍

㹙2022/11/04㹛㸦ཱྀ㢌Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔

20. ᐑୗගᘯࠊᒣᓮಟ㐨ࠊᏳ⸨ಇኴ㑻ࠊ㕥ᮌ୍ᾈࠊ㫽ᾏ࿴ஓࠊ㐲⸨㤶⧊ࠊ୰ᓥ┤⨾ࠊᒣཱྀᬛྐࠊす⏣῟ᚿࠊ᪂஭ㄔ㸬ᮍ᭹⸆ᛮ᫓ᮇඣ❺࡟࠾ࡅࡿᒀ୰࣌ࣥࢺࢩࢪࣥ࡜⢭⚄⑓⌮ࡢ㛵㐃㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍ 㹙2022/11/05㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸ
ࣝ/ᮾி㒔
21. ▼⏣⿱᫛ࠊᐑୗගᘯࠊ኱ᓥ೺୍ࠊἙୖ⥴ࠊ㛵ᒣ୍ᡂࠊ㬨Ụ┿⥔ࠊ㛵⤮㔛㤶ࠊ᪂஭ಙ㝯ࠊ℧⃝ಇஓࠊỌ⏣ᰤ୍㑻ࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕ᝈ⪅Ṛᚋ⬻ࡢ኱⬻ᇶᗏ᰾ᑠ⬻࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ⵳✚ BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍㸧㹙2022/11/04㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
22. ⏣⏿ග୍ࠊᏞᶞ὜ࠊᐑ⏣῟ࠊ▼⏣⿱᫛ࠊ⣒ᕝᫀᡂࠊ㧗ᶫⱥᙪࠊᮧ஭ಇဢࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ࣍ࣔࢩࢫࢸ࢖ࣥ࡜ⓑ㉁ᚤ⣽ᵓ㐀ࡢ㛵㐃㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍
㹙2022/11/04㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
23. ⋤ᜣ෈ࠊ㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊᑠ⃝᭷㒔⳯ࠊṇ⏣┿ౡᏊࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⫾ඣᮇ࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝ᭚㟢ࡀᡂయᮇ࣐࢘ࢫࡢ⾜ື࡜⚄⤒ఏ㐩⣔࡟୚࠼ࡿ㛗ᮇⓗ࡞ᙳ㡪㸬
BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍ 㹙2022/11/04㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
－7 －24. ᑠ⃝᭷㒔⳯ࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊᐑୗගᘯࠊ㐲⸨ᙯ๎ࠊబ఑Ὀࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ㸬⤫ྜኻㄪ⑕࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ⵳✚⑓ែࡢゎ᫂㸬BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍
㹙2022/11/04㹛㸦࣏ࢫࢱ࣮Ⓨ⾲㸧㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ/ᮾி㒔
25. ⏣⏿ග୍ࠊᐑୗගᘯࠊᒣᓮಟ㐨ࠊ㫽ᾏ࿴ஓࠊᏳ⸨ಇኴ㑻ࠊ㕥ᮌ୍ᾈࠊ㧗ᶫⱥᙪࠊ➟஭Ύ
Ⓩࠊ⣒ᕝᫀᡂࠊす⏣῟ᚿࠊ᪂஭ㄔ㸬ᛮ᫓ᮇ࡟࠾ࡅࡿẟ㧥ள㖄⃰ᗘ࡜⢭⚄⑓Ⓨ⑕ࣜࢫࢡࡢ
㛵㐃㸬➨ 33 ᅇ᪥ᮏᚤ㔞ඖ⣲Ꮫ఍㹙2022/9/9㹛㸦ཱྀ㢌Ⓨ⾲㸧ῐ㊰ክ⯙ྎᅜ㝿఍㆟ሙ㸭රᗜ┴ῐ㊰ᕷIII. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧

IV. ≉グ஦㡯
1. 2022 ᖺ 11 ᭶ 12 ᪥ࠊ➨ 32 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ᖺ఍࡟࠾࠸࡚ࠊ㐃ᦠ኱Ꮫ㝔⏕ࡢ⋤ᜣ෈ࠊ㣤㔝㡪ḷࡀඃ⚽࣏ࢫࢱ࣮㈹ࢆཷ㈹࣭⋤ᜣ෈㸸⫾ඣᮇ࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝ᭚㟢ࡀᡂయᮇ࣐࢘ࢫࡢ⾜ື࡜⚄⤒ఏ㐩⣔࡟୚࠼ࡿ㛗ᮇⓗ࡞ᙳ㡪
࣭㣤㔝㡪ḷ㸸࣌ࣥࢺࢩࢪࣥ⵳✚ᆺ⤫ྜኻㄪ⑕࡟࠾ࡅࡿ AKR1A1 ࡢ㑇ఏᏊゎᯒ
2. 2022 ᖺ 11 ᭶ 4 ᪥ࠊ➨ 44 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍࡟࠾࠸࡚ࠊ⏣⏿ග୍㠀ᖖ໅◊✲ဨࡀࠊඃ⚽₇㢟Ⓨ⾲ᙲࢆཷ㈹࣭◊✲ㄢ㢟ࠕ⤫ྜኻㄪ⑕࡟࠾ࡅࡿ࣍ࣔࢩࢫࢸ࢖ࣥ࡜ⓑ㉁ᚤ⣽ᵓ㐀ࡢ㛵㐃ࠖ

－7 －ࣉࣟࢪ࢙ࢡࢺྡ

╧╀ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Akiyo Natsubori, Shinobu Hirai, Soojin Kwon, Daisuke Ono, Fei Deng, Jinxia

an, Momoka

Miyazawa, Takashi Kojima, Haruo Okado, Akihiro Karashima, Yulong Li, Kenji F Tanaka,
Makoto Honda. Serotonergic neurons control cortical neuronal intracellular energy dynamics bymodulating astrocyte-neuron lactate shuttle. iScience., 26:105830, 2023 doi:
10.1016/j.isci.2022.105830.
2.

Akiyo Natsubori, Momoka Miyazawa, Takashi Kojima, Makoto Honda. Region-specificinvolvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in
nociception. Neuroscience Research., 2023 Jun 191:48-56.doi: 10.1016/j.neures.2022.12.008B,
202212.

3.

Susumu Tanaka, Yoshiko Honda, Misa Sawachika, Kensuke Futani, Namika Yoshida, Tohru
Kodama. Degradation of STK16 via KCTD17 with Ubiquitin-Proteasome System in Relation to
Sleep- ake Cycle. Kinases and Phosphatases. 2023, 1(1) 14-22
https://doi.org/10.3390/kinasesphosphatases1010003

4.

Makoto Honda, Yosuke Shigematsu, Mihoko Shimada, Yoshiko Honda, Katsushi Tokunaga, Taku
Miyagawa. Low carnitine palmitoyltransferase1 activity is a risk factor for narcolepsy type 1 andother hypersomnia. Sleep., A, 20220710. (doi.org/10.1093/sleep/zsac160)

5.

Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu
Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi
Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamatoada, Masayuki

Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto
Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun
Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji
Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji
Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda. A rare genetic variant in thecleavage site of prepro-orexin is associated with idiopathic hypersomnia. npj Genomic Medicine.,
7, 1: 20220412. (doi.org/10.1038/s41525-022-00298-w)
6.

Yu Itoh, Masahiro Takeshima, Yoshitaka Kaneita, Naohisa Uchimura, Yuichi Inoue, Makoto
Honda,

ataru Yamadera, Norioatanabe, Shingo Kitamura, Isa Okajima, Naoko Ayabe, Kyoko－－

Nomura, Kazuo Mishima. Associations Between the 2011 Great East Japan Earthquake andTsunami and the Sleep and Mental Health of Japanese People: A 3- ave Repeated Survey.
Nature and Science of Sleep., 14:61-73, 2022 DOI: 10.2147/NSS.S338095

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 5 ௳㸧

Honda M: Search for the personality characteristic for narcolepsy type 1. Sleep Biol Rhythms 21,
pages 1 2 (2023) doi.org/10.1007/s41105-022-00430-42.

ᮏከ┿㸸ࢼࣝࢥࣞࣉࢩ࣮࡟࠾ࡅࡿ㐣╀ࡢ⑓ែᇶ┙ ⢭⚄་Ꮫ 64:1319-1326 2022/10/15

3.

ኟᇼ᫭ୡ㸸࢔ࢫࢺࣟࢧ࢖ࢺࡢ࢚ࢿࣝࢠ࣮௦ㅰㄪ⠇ᶵ⬟࡜ᙺ๭ ࣇ࢓࣐ࣝࢩ࢔ ᪥ᮏ⸆Ꮫ఍
58: 877-881, 2022/9/01

4.

ᮏከ┿㸸╧╀ ぬ㓰㞀ᐖࡢᅜ㝿デ᩿ศ㢮 DSM-5 ࡢၥ㢟Ⅼࡶྵࡵ࡚ ⢭⚄⛉ Resident 2022
ᖺ Summe ྕ .3(3):12 2022/08/20

5.

ᮏከ┿㸸╧╀࣭ぬ㓰㞀ᐖ(Sleep-wake Disorders) ICD-11 ศ㢮࡜⑓ྡゎㄝࢩ࣮ࣜࢬྛㄽ 12⢭⚄⤒ㄅ 124: 192-197,2022.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧
1.

ኟᇼ᫭ୡ㸸ࢭࣟࢺࢽࣥ⚄⤒ㄪ⠇ୗࡢ࢔ࢫࢺࣟࢧ࢖ࢺ࡟ࡼࡿ⬻ෆ࢚ࢿࣝࢠ࣮௦ㅰㄪ⠇ᶵᵓ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍࣮࣡ࢡࢩࣙࢵࣉ ᣍᚅㅮ₇ >@2.

ᮏከ┿㸸ࢼࣝࢥࣞࣉࢩ࣮࡜ࣄࢫࢱ࣑ࣥ➨  ᅇᛂ⏝⸆⌮ࢩ࣏ࣥࢪ࣒࢘ ᣍᚅㅮ₇ =RRP
࢙࢘ࣅࢼ࣮>@3.

ᮏከ┿㸸㐣╀⑕ࡢ㚷ูデ᩿̿ࢩ࣏ࣥࢪ࣒࢘  ኱Ꮫ⏕ࡢ╧╀ၥ㢟࡜࣏ࢫࢺࢥࣟࢼ♫఍࡟࠾ࡅࡿᑐ⟇ ➨  ᅇ᪥ᮏ╧╀Ꮫ఍ᐃᮇᏛ⾡㞟఍ࠊி㒔>@4.

ᮏከ┿㸸ධ╀᫬࣒ࣞ╧╀ᮇ㸸᪂ࡓ࡞╀Ẽホ౯ἲ̿ࢩ࣏ࣥࢪ࣒࢘  ୰ᯡᛶ㐣╀⑕ XSGDWH
➨  ᅇ᪥ᮏ╧╀Ꮫ఍ᐃᮇᏛ⾡㞟఍ࠊி㒔>@5.

ᮏከ┿㸸㐣╀⑕デ᩿ࡢㄢ㢟̿ࢩ࣏ࣥࢪ࣒࢘  㟂せ㧗ࡲࡿ 06/7 ࡢ㐺ṇ࡞㐠⏝ࢆ⪃࠼ࡿ➨ ᅇ᪥ᮏ╧╀Ꮫ఍ᐃᮇᏛ⾡㞟఍ࠊி㒔>@6.

ᐑᕝ༟㸸≉Ⓨᛶ㐣╀⑕ឤཷᛶ㑇ఏᏊࡢྠᐃࢩ࣏ࣥࢪ࣒࢘  ୰ᯡᛶ㐣╀⑕ XSGDWH➨ ᅇ᪥ᮏ╧╀Ꮫ఍ᐃᮇᏛ⾡㞟఍ࠊி㒔>@－ 1－ࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

Miyagawa T et al, A rare genetic variant in the cleavage site of prepro-orexin is associated with
idiopathic hypersomnia. ASHG Annual Meeting 2022, 2022/10/26

2.

M Honda,Ito: Sleep Onset REM Period Beyond the Diagnostic Marker. SLEEP2022, Charlotte

Convention Center NC USA 2022/06/05
3.

ᐑᕝ༟௚㸸࢜ࣞ࢟ࢩࣥ๓㥑య㑇ఏᏊࡢ⛥࡞ኚ␗࡜≉Ⓨᛶ㐣╀⑕࡜ࡢ㛵㐃 ᪥ᮏே㢮㑇ఏᏛ఍➨4.

ᅇ኱఍ ᶓ὾ኟᇼ ᫭ୡ㸸ࠕࢭࣟࢺࢽࣥ⚄⤒࡜࢔ࢫࢺࣟࢧ࢖ࢺ௦ㅰࢿࢵࢺ࣮࣡ࢡ࡟ࡼࡿ࢚ࢿࣝࢠ࣮ᜏᖖ
ᛶ⥔ᣢࡢゎ᫂ࠖᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝⿵ຓ㔠 Ꮫ⾡ኚ㠉㡿ᇦ◊✲ࢢ ➨ࢢࣜ࢔ࢹࢥ࣮ࢹ࢕ࣥ

ᅇࢢࣜ࢔ࢹࢥʊࢻ㡿ᇦ఍㆟

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 10 ௳㸧1.

ᮏከ┿㸸╧╀࡜ࡇࡇࢁࡢ೺ᗣ ୡ⏣㇂༊ಖ೺ࢭࣥࢱ࣮ㅮ₇఍2.

ᮏከ┿㸸╧╀㞀ᐖࡢ⑓ែ࡜἞⒪ ௧࿴㸲ᖺᗘ⸨ᯞ⸆๣ᖌᐃ౛◊ಟ఍

3.

ᮏከ┿㸸≉Ⓨᛶ㐣╀⑕ࡢデ᩿ࢆࡵࡄࡗ࡚

᪥ᮏࢼࣝࢥࣞࣉࢩ࣮༠఍ ➨ᅇᐃᮇ⥲఍࢜ࣥࣛ࢖ࣥබ㛤ㅮ₇఍
4.

ᮏከ┿ࠊᐑᕝ༟㸸╧╀Ꮫ࡬ࡢᣍᚅ 㒔❧ᡞᒣ㧗ᰯ5.

ᮏከ┿㸸ᒸᒣ᧯ᒣ୰Ꮫ ◊✲ᡤぢᏛ ་Ꮫ◊6.

ᮏከ┿㸸ࡑࡢ╀Ẽࠊ⑓Ẽ࠿ࡶ ╀Ẽࡢホ౯࡜ ᒃ╀ࡾ⑓ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ
➨7.

ㅮ₇఍ ᡞᒣ㧗ᰯㅮᇽ

ࢭ࣑ࢼ࣮ᐊ
ᖺᗘ

ᅇ㒔Ẹㅮᗙ ་Ꮫ◊ㅮᇽᮏከ┿㸸Ꮚ౪ࡢ╧╀࡜೺ᗣ 㺀ࡍ࠸ࡳࢇࡢ᪥㺁≉ู௻⏬ ╧╀೺ᗣ᥎㐍ᶵᵓ࢜ࣥࣛ࢖ࣥࢭ࣑
ࢼ࣮

8.

ኟᇼ᫭ୡ㸸╧╀ぬ㓰࡟క࠺⬻ෆ࢚ࢿࣝࢠ࣮௦ㅰㄪ⠇࡟࠾ࡅࡿࢭࣟࢺࢽࣥ⚄⤒ࡢᙺ๭➨

9.

◊✲஺ὶࣇ࢛࣮࣒ࣛ

ᮏከ┿㸸≉Ⓨᛶ㐣╀⑕ࡢデ᩿࡜἞⒪ ➨ᅇ╧╀་Ꮫࢭ࣑ࢼ࣮ ᗈᓥ኱Ꮫ኱Ꮫ㝔╧╀་Ꮫㅮᗙ
10. ᮏከ┿㸸╧╀ࡢ㉁࡜ࡣఱ࠿

໭ᾏ㐨ᩍ⫱኱Ꮫ㝃ᒓภ㤋୰Ꮫ ◊✲ᡤぢᏛ－－

IV. ≉グ஦㡯࠙ཷ㈹ࠚ
ᐑᕝ༟ ⌮஦㛗⾲ᙲຌ⦼㢧ⴭ㒊㛛ࠕ࣑࢜ࢵࢡࢫゎᯒ࡟ࡼࡿ୰ᯡᛶ㐣╀⑕ࡢ⑓ែゎ᫂ࠖ࠙≉チࠚᴙᯘ⩏Ꮥ ᯇ⏣ⰾᶞ ⠛ᓮࡓࡁᏊ ᑠ⃝ಙᖾ Ώ㑓ⴌ 㜿㒊ᆂ୍ ᮧᒣᐉே㸸≉チ➨ྕ࠺ࡘ⑓ࡸᛴᛶࢫࢺࣞࢫ㞀ᐖࡢデ᩿ࣂ࢖࣐࣮࣮࢜࢝ཬࡧ἞⒪ཪࡣண㜵⏝⤌ᡂ≀࠙ጤဨࠚ
1.

ᮏከ┿㸸ཌ⏕ປാ┬2.

ᮏከ┿㸸᪥ᮏ╧╀Ꮫ఍⌮஦ᑓ㛛ጤဨ⥲ົጤဨ㛗ࠊデ᩿ศ㢮ጤဨ㛗ࠊᣦᐃ㞴⑓᳨ウጤဨ఍ጤဨ

㛗ࠊ╧╀Ꮫࡢⓒ⛉஦඾⦅㞟ጤဨ఍๪ጤဨ㛗ࠊᑗ᮶ᵓ᝿ጤဨ఍ጤဨࠊ㈈ົጤဨ఍ጤဨࠊ฼
┈┦཯ጤဨ఍ጤဨࠊホ㆟ဨ᥎⸀ጤဨ఍ጤဨࠊᶵ㛵⣬⦅㞟ጤဨ఍ጤဨ
3.

ᮏከ┿㸸᪥ᮏ⢭⚄⚄⤒Ꮫ఍4.

ᮏከ┿㸸ࠕ╧╀་⒪ࠖ⦅㞟ጤဨࠊ Sleep Biological Rhythms Associate Editor5.

ᐑᕝ༟㸸᪥ᮏ⤌⧊㐺ྜᛶᏛ఍6.

ᐑᕝ༟㸸ᩥிᏛ㝔኱Ꮫ࣭ಖ೺་⒪ᢏ⾡Ꮫ㒊ࠊᮾி኱Ꮫ࣭་Ꮫ㒊࣭་Ꮫ⛉ࠊᮾி኱Ꮫ࣭་

⢭⚄⛉⑓ྡ᳨ウ㐃⤡఍ጤဨ⌮஦࣭ホ㆟ဨ➼㑅௵ጤဨ఍ጤဨཬࡧ⦅㞟ᗈሗጤဨ఍ጤဨ

Ꮫ㒊࣭೺ᗣ⥲ྜ⛉Ꮫ⛉ ே㢮㑇ఏᏛ㠀ᖖ໅ㅮᖌ7.

ኟᇼ᫭ୡ㸸ᮾிዪᏊ་⛉኱Ꮫ ་Ꮫ㒊 ⚄⤒⏕⌮Ꮫศ㔝 㠀ᖖ໅ㅮᖌࡲࡓࡣ≉ูㅮᖌ8.

ᯇ⏣ⰾᶞ㸸᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ホ㆟ဨ－－ࣉࣟࢪ࢙ࢡࢺྡ

౫Ꮡᛶ≀㉁ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 21 ௳㸧
1.

Shoji H, Ikeda K, Miyakawa T (2023) Behavioral phenotype, intestinal microbiome, and brainneuronal activity of male serotonin transporter knockout mice. Mol Brain 16(1):32. ᰝㄞ᭷ doi:
10.1186/s13041-023-01020-2.

2.

Moriya Y, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS,
Uhl GR, Sora I (2023) Role for mu-opioid receptor in antidepressant effects of delta-opioid
receptor agonist KNT-127. J Pharmacol Sci 151(3):135-141. ᰝㄞ᭷ doi:
10.1016/j.jphs.2022.12.008.

3.

Nago-Iwashita Y, Moriya Y, Hara S, Ogawa R, Aida R, Miyajima K, Shimura T, Muramatsu S, Ide
S, Ikeda K, Ichinose H (2023) Overexpression of tyrosine hydroxylase in dopaminergic neurons
increased sensitivity to methamphetamine. Neurochem Int 164:105491. ᰝㄞ᭷ doi:
10.1016/j.neuint.2023.105491.

4.

Kashii K, Kasai S, Sato A, Hagino Y, Nishito Y, Kobayashi T, Hino O, Mizuguchi M, Ikeda K(2023) Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mousemodel of tuberous sclerosis complex. Hum Genomics 17(1):4. ᰝㄞ᭷ doi: 10.1186/s40246-02300450-2.

5.

Ide S, Iwase N, Arai K, Kojima M, Ushiyama S, Taniko K, Ikeda K (2023) Inhibitory effects of anovel mu-opioid receptor nonpeptide antagonist, UD-030, on morphine-induced conditioned place
preference. Int J Mol Sci 24(4):3351 ᰝㄞ᭷ doi: 10.3390/ijms24043351.

6.

Aoki Y, Nishizawa D, Ohka S, Kasai S, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S,
Hiranuma A, Hasegawa J, Nakayama K, Ebata Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K(2023) rs11726196 single-nucleotide polymorphism of the transient receptor potential canonical 3(TRPC3) gene is associated with chronic pain. Int J Mol Sci 24(2):1028 ᰝㄞ᭷ doi:
10.3390/ijms24021028.

7.

Sasaki K, Rabozzi R, Kasai S, Ikeda K, Ishikawa T (2023) Fentanyl-induced muscle rigidity in adog during weaning from mechanical ventilation after emergency abdominal surgery: A casereport. Vet Med Sci 9(1):37-42. ᰝㄞ᭷ doi: 10.1002/vms3.1001.

－

－

8.

Katoh Y, Iriyama T, Yano E, Sayama S, Seyama T, Kotajima-Murakami H, Sato A, Sakuma H,
Iguchi Y, Yoshikawa M, Inaoka N, Ichinose M, Toshimitsu M, Sone K, Kumasawa K, Nagamatsu
T, Ikeda K, Osuga Y (2022) Increased production of inflammatory cytokines and activation of
microglia in the fetal brain of preeclamptic mice induced by angiotensin II. J Reprod Immunol
154:103752. ᰝㄞ᭷ doi: 10.1016/j.jri.2022.103752.

9.

Ohka S, Hao Tan S, Kaneda S, Fujii T, Schiavo G (2022) Retrograde axonal transport ofpoliovirus and EV71 in motor neurons. Biochem Biophys Res Commun 626:72-78. ᰝㄞ᭷ doi:
10.1016/j.bbrc.2022.08.015.

10. 㔠๛ᕥிࠊ୕ୖ㯞㔛ዉࠊ㟷ᮌ⌮ャࠊỌ㇂(἟ᑼ)┿㈗ࠊす⃝኱㍜ࠊụ⏣࿴㝯ࠊᒾᶫ࿴ᙪࠊ
ᑠ㔝⃝⿱ஓ (2022) ⫧‶࡜㑇ఏᏊከᆺ (ADRB3, HTR2A, NOS1) ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚ࡢ᳨ウ.

་Ꮫ᳨ᰝ 71(4):651-656. ᰝㄞ᭷ doi: 10.14932/jamt.22-14.
11.

Ohka S, Tan SH, Ishiyama E, Ogasawara K, Hanasaka T, Ishida K, Hagiwara K, Liu CC, Chong
PC, Hanaki KI, Schiavo G (2022) The uncoating of EV71 in mature late endosomes requires CDM6PR. Biol Open 11(9):bio059469. ᰝㄞ᭷ doi: 10.1242/bio.059469.

12. Fujita M, Ochiai Y, Hagino Y, Kobayashi K, Pavey G, Dean B, Ikeda K (2022) Involvement ofmuscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice. Mol Brain
15(1):96. ᰝㄞ᭷ doi: 10.1186/s13041-022-00984-x.
13. Nishizawa D, Terui T, Ishitani K, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Ikeda K (2022)
Genome-wide association study identifies candidate loci associated with opioid analgesic
requirements in the treatment of cancer pain. Cancers 14(19):4692. ᰝㄞ᭷ doi:
10.3390/cancers14194692.
14. Tanaka M, Sato A, Kotajima-Murakami H, Kashii H, Hagino Y, Ide S, Ikeda K (2022) Interaction
between social behavior and paternal age in offspring of the same paternal mice.
Neuropsychopharmacol Rep 42(3):343-346. ᰝㄞ᭷ doi: 10.1002/npr2.12258.
15. Saita K, Sumitani M, Nishizawa D, Tamura T, Ikeda K,

akai K, Sudo Y, Abe H, Otonari J,

Ikezaki H, Takeuchi K, Hisida A, Tanaka K, Shimanoe C, Takezaki T, Ibusuki R, Oze I, Ito H,
Ozaki E, Matsui D, Nakamura Y, Kusakabe M, Suzuki S, Nakagawa-Senda H, Arisawa K,
Katsuura-Kamano S, Kuriki K, Kita Y (2022) Genetic polymorphism of pleiotrophin is associatedwith pain experience in Japanese adults: case-control study. Medicine 101(37):e30580. ᰝㄞ᭷
doi: 10.1097/MD.0000000000030580.
16.

Ohi K, Nishizawa D, Sugiyama S, Takai K, Fujikane D, Kuramitsu A, Hasegawa J, Soda M,
Kitaichi K, Hashimoto R, Ikeda K, Shioiri T (2022) Cognitive performances across individuals athigh genetic risk for schizophrenia, high genetic risk for bipolar disorder, and low genetic risks: a
combined polygenic risk score approach. Psychol Med 1-10. ᰝㄞ᭷ doi:
10.1017/S0033291722001271.

－ 5－

17. Ochiai Y, Fujita M, Hagino H, Kobayashi K, Okiyama R, Takahashi K, Ikeda K (2022)
Therapeutic effects of quetiapine and 5-HT1A receptor agonism on hyperactivity in dopaminedeficient mice. Int J Mol Sci 23(13):7436. ᰝㄞ᭷ doi: 10.3390/ijms23137436.
18. Mikami M, Kongo S, Aoki R, Kawai A, Nishizawa D, Ikeda K, Onozawa Y, Iwahashi K (2022)
Association between mu opioid receptor gene polymorphisms and alcohol dependence in a
Japanese population. Japanese Journal of Medical Technology 71(3):424-430. ᰝㄞ᭷ doi:
10.14932/jamt.22-5.
19. Hashimoto K, Ide S, Arata M, Nakata A, Ito A, Ito TK, Kudo N, Lin B, Nunomura K,
Tsuganezawa K, Yoshida M, Nagaoka Y, Sumiyoshi T (2022) Discovery of benzylpiperazine
derivatives as CNS-penetrant and selective histone deacetylase 6 inhibitors. ACS Med Chem Lett
13(7):1077-1082. doi: 10.1021/acsmedchemlett.2c00081.
20. ୕ୖ㯞㔛ዉࠊ㔠๛ᕥிࠊ㟷ᮌ⌮ャࠊす⃝኱㍜ࠊụ⏣࿴㝯ࠊᮏ⏣᫭Ꮚࠊ ᑠ㔝⃝⿱ஓࠊᒾᶫ
࿴ᙪ (2022) 㧗⾑ᅽ࡜ HTR2A, NOS3, ADRB3 ࣂࣜ࢔ࣥࢺࡢ⤌ࡳྜࢃࡏ࠾ࡼࡧ୙Ᏻ࡜ࡢ㛵㐃. ᪥ᮏ⮫ᗋ᳨ᰝ་Ꮫ఍ㄅ 70(6):471-476. ᰝㄞ᭷
21. 㔠๛ᕥிࠊ୕ୖ㯞㔛ዉࠊ㟷ᮌ⌮ャࠊ ᑠ㔝⃝⿱ஓࠊᮏ⏣᫭Ꮚࠊす⃝኱㍜ࠊụ⏣࿴㝯ࠊᒾᶫ࿴ᙪ (2022) ᪥ᮏேዪᛶ࡟࠾ࡅࡿ CYP2C19 㑇ఏᏊከᆺ࡜㛤ᨺᛶࡢ㛵㐃. ᪥ᮏ࢔ࣝࢥ࣮ࣝ

⸆≀་Ꮫ఍㞧ㄅ 57(2):81-89. ᰝㄞ᭷ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 7 ௳㸧

Kotajima-Murakami H, Ide S, Ikeda K (2022) GIRK channels as candidate targets for thetreatment of substance use disorders. Biomedicines 10(10):2552. ᰝㄞ᭷ doi:
10.3390/biomedicines10102552.

2.

᳃஭㞞Ꮚࠊす⃝኱㍜ࠊ ụ⏣࿴㝯 (2022) 㑇ఏᏊከᆺ࡜࢜ࣆ࢜࢖ࢻ㸫㑇ఏᏊ࡟ࡼࡾ࢜ࣆ࢜
࢖ࢻࡢຠᯝ㸪๪స⏝ࡢண ࡀ࡛ࡁࡿࡢ࠿. LiSA 29 ู෉ 22 ⛅ྕ :157-163. ᰝㄞ↓

3.

஭ᡭ⪽୍㑻ࠊఀబṇࠊす㇂㝧Ꮚࠊ༡㞞ᩥࠊᮧ஭ಇဢࠊ㧘ᶫⱥᙪࠊᐑ⏣ஂႹࠊஂᡃᘯ඾ࠊ
ᯇᮏಇᙪࠊ୰㎸࿴ᖾࠊ ụ⏣࿴㝯 (2022) ࢃࡀᅜ࡟࠾ࡅࡿ࢔ࢹ࢕ࢡࢩࣙࣥ◊✲ࡢ᪉ྥᛶ.

⢭⚄⛉ 41(2):279-285. ᰝㄞ↓
4.

す⃝኱㍜ࠊụ⏣࿴㝯ࠊ↷஭೺ (2022) ࡀࢇᝈ⪅࡟࠾ࡅࡿ⑊③἞⒪ࡢຠᯝ࡟㛵ࢃࡿ㑇ఏᏊせᅉࡢ᥈⣴. ⮫ᗋ⸆⌮ࡢ㐍Ṍ 43:132-139. ᰝㄞ᭷

5.

ụ⏣࿴㝯 (2022) ࢔ࢹ࢕ࢡࢩࣙࣥ࡜⬻. In: య࡜ᚰ ಖ೺⥲ྜ኱ⓒ⛉ ୰࣭㧗ᰯ⦅ 2022,
pp136-138. ᮾி: ᑡᖺ෗┿᪂⪺♫. ᰝㄞ↓

6.

ᯘ⏣┾࿴ࠊす⃝኱㍜ࠊụ⏣࿴㝯 (2022) ࢜ࣆ࢜࢖ࢻཷᐜయ㑇ఏᏊࢆྵࡴ㛵㐃㑇ఏᏊ࡜࢜ࣆ࢜࢖ࢻឤཷᛶ㸫ࡀࢇᛶ⑊③࢜ࣆ࢜࢖ࢻ἞⒪ࡢᑗ᮶࡬ྥࡅ࡚. In: ࡀࢇᛶ⑊③ ⸆ࡢ౑࠸᪉
(ⰼᒸ୍㞝⦅), pp164-168. ᮾி: ඞㄔᇽฟ∧. ᰝㄞ↓
－ 6－

7.

Sato A, Ikeda K (2022) Genetic and environmental contributions to autism spectrum disorderthrough mechanistic target of rapamycin. Biological Psychiatry: Global Open Science 2(2):95105. ᰝㄞ᭷ doi: 10.1016/j.bpsgos.2021.08.005.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

ụ⏣࿴㝯.

ᅜ㝿Ꮫ఍ࠊᏛ఍㐃ྜࠊᏛ⾡఍㆟➼࡛ࡢ㐃ᦠಁ㐍࡟ࡼࡿඞ᭹. BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.6 㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊
2.

Ikeda K, Nishizawa D, Hayashida M, Fukuda K. Genetic mechanisms underlying individual
differences in opioid sensitivity revealed by genome-wide association studies. 33rd CINP
Congress of Neuropharmacology. 2022.6.10 Virtual

orld

Taipei, Taiwanࡑࡢ௚ 㸦ィ 30 ௳㸧⮬⏤ᥖ㍕
1.

஭ᡭ⪽୍㑻ࠊᒾ℩ᚨ᫂ࠊ᪂஭೺୍ࠊᑠᓥṇ⿱ࠊ∵ᒣⱱࠊ㇂ྂ㤶ࠊụ⏣࿴㝯. ᪂つ ȝ ࢜ࣆ࢜࢖ࢻཷᐜయ㑅ᢥⓗ࢔ࣥࢱࢦࢽࢫࢺ UD-030 ࡢࣔࣝࣄࢿሗ㓘స⏝࡟ᑐࡍࡿຠᯝ.

᪥ᮏ⸆Ꮫ఍➨ 143 ᖺ఍. 2023.3.26 ໭ᾏ㐨኱Ꮫ, ໭ᾏ㐨ᮐᖠᕷ
2.

஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯. Addiction-like behaviors in laboratory animals. ᪥ᮏ⏕⌮Ꮫ఍➨100 ᅇグᛕ኱఍. 2023.3.14 ᅜ❧ி㒔ᅜ㝿఍㤋, ி㒔ᗓி㒔ᕷ3.

す⃝኱㍜ࠊ↷஭೺ࠊ▼㇂㑥ᙪࠊ➟஭ៅஓࠊ㛗㇂ᕝ‽Ꮚࠊ୰ᒣிᏊࠊỤ⏿⿱Ꮚࠊụ⏣࿴㝯.
ࡀࢇᛶ⑊③἞⒪࡟࠾ࡅࡿ࢜ࣆ࢜࢖ࢻ㙠③⸆ᚲせ㔞ࡢࢤࣀ࣒࣡࢖ࢻゎᯒ. ᪥ᮏே㢮㑇ఏᏛ఍➨ 67 ᅇ኱఍. 2022.12.15㹼12.17 ࣃࢩࣇ࢕ࢥᶓ὾, ⚄ዉᕝ┴ᶓ὾ᕷ

4.

ᒣᓊឡᐇࠊ஭ᡭ⪽୍㑻ࠊụ❑⤖Ꮚࠊ୕ရᫀ⨾ࠊụ⏣࿴㝯. NMDA ཷᐜయ GluN2D ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ࡟࠾ࡅࡿ(2R,6R)-ࣄࢻࣟ࢟ࢩࣀࣝࢣࢱ࣑ࣥࡢᣢ⥆ⓗᢠ࠺ࡘຠᯝࡢᾘኻ.
JP 2022㸦➨ 96 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍ / ➨ 43 ᅇ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍Ꮫ⾡⥲఍
ദ㸧.

5.

ྠ᫬ᮇ㛤

2022.12.3 ࣃࢩࣇ࢕ࢥᶓ὾, ⚄ዉᕝ┴ᶓ὾ᕷ኱஭୍㧗ࠊす⃝኱㍜ࠊᮡᒣಇ௓ࠊ㧗஭೺ኴᮁࠊ⸨ව኱㍜ࠊ⸝‶ᙬ⤖ᐇࠊ㛗㇂ᕝ‽Ꮚࠊ᭮⏣⩫ࠊ໭ᕷΎᖾࠊᶫᮏுኴࠊụ⏣࿴㝯ࠊሷධಇᶞ. ⤫ྜኻㄪ⑕ࡢ㧗㑇ఏⓗࣜࢫࢡ⩌ࠊ཮ᴟᛶ㞀ᐖࡢ㧗㑇ఏⓗࣜࢫࢡ⩌ࠊ࠾ࡼࡧప㑇ఏⓗࣜࢫࢡ⩌࡟࠾ࡅࡿㄆ▱ᶵ⬟㸸」ྜⓗ࡞࣏ࣜࢪ࢙ࢽࢵࢡࣜࢫࢡࢫࢥ࢔࡟ࡼࡿ࢔ࣉ࣮ࣟࢳ.

BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.5 㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊6.

す⃝኱㍜ࠊ↷஭೺ࠊ▼㇂㑥ᙪࠊ➟஭ៅஓࠊ㛗㇂ᕝ‽Ꮚࠊ୰ᒣிᏊࠊỤ⏿⿱Ꮚࠊụ⏣࿴㝯.

ࢤࣀ࣒࣡࢖ࢻ㛵㐃ゎᯒ(G AS)࡟ࡼࡿࡀࢇᛶ⑊③἞⒪࡟࠾ࡅࡿ࢜ࣆ࢜࢖ࢻ㙠③⸆ᚲ

せ㔞࡟ᙳ㡪ࡍࡿ㑇ఏᏊከᆺࡢྠᐃ. BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11..5
－ 7－

㒔ᕷࢭࣥ

ࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊
7.

኱ᒸ㟼⾰ࠊᒣ⏣ኊ୍ࠊᮌୗ୍⨾ࠊ⚟஭ⰋᏊࠊ㛗㇂ᕝ‽Ꮚࠊす⃝኱㍜ࠊ⚟ኈ⚽ᝋࠊᾏ⪁ཎ⚽႐ࠊụ⏣࿴㝯. ᖏ≧⑁⑈࣭ᖏ≧⑁⑈ᚋ⚄⤒③࡟㛵㐃ࡍࡿ heparan sulfate glucosamine 3O-sulfotransferase 4 ࡢ SARS-CoV-2 ឤᰁ࡟ཬࡰࡍᙳ㡪. BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍.
2022.11.5

8.

㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊ᒣᓊឡᐇࠊ஭ᡭ⪽୍㑻ࠊụ❑⤖Ꮚࠊ୕ရᫀ⨾ࠊụ⏣࿴㝯. NMDA ཷᐜయ GluN2D ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ࡟࠾ࡅࡿ(2R,6R)-ࣄࢻࣟ࢟ࢩࣀࣝࢣࢱ࣑ࣥࡢᣢ⥆ⓗᢠ࠺ࡘຠᯝࡢᾘኻ.
BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.5

9.

す⃝኱㍜ࠊụ⏣࿴㝯. 㞴἞ᛶ⑊③ཬࡧ㙠③࣭⸆≀౫Ꮡ࡟㛵㐃ࡍࡿ㑇ఏᏊከᆺ.
BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍.

10.

㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊

2022.11.5

㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊ఫ㇂ᫀᙪࠊⶶ㔝ಙࠊᅵ⏣㝣ᖹࠊす⃝኱㍜ࠊụ⏣࿴㝯. ③ࡳ࡜ࣜࢰ࣍ࢫࣇ࢓ࢳࢪࣥ㓟
㸦LPA㸧ࢩࢢࢼࣜࣥࢢ. BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.5

㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ,ᮾி㒔༓௦⏣༊11.

ⴗཎⱥ㞝ࠊᑠΎỈஂႹࠊ᭹㒊⪽Ꮚࠊ⏣୰⨾Ṍࠊụ⏣࿴㝯ࠊᐑᕝ๛.

࣐࢘ࢫᾏ㤿࡟࠾ࡅ

ࡿ㐣ᡂ⇍⌧㇟. BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.4 㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔
༓௦⏣༊
12.

ྂ⏣ᓥᾈᏊࠊⴗཎⱥ㞝ࠊబ⸨ᩔᚿࠊⴗ㔝ὒᏊࠊ⏣୰⨾Ṍࠊຍ⸨႐ஂࠊす⸨Ὀᫀࠊ㧗ᯇᖾ㞝ࠊෆ㔝ⱱኵࠊᐑᕝ๛ࠊụ⏣࿴㝯. GABAA ཷᐜయ࢔ࣥࢱࢦࢽࢫࢺࡢࣆࢡࣟࢺ࢟ࢩࣥᭀ
㟢࡟ࡼࡿ௘ࡢ⮬㛢⑕ᵝ⾜ື࡜㑇ఏᏊⓎ⌧ゎᯒ.

BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍. 2022.11.4

㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ᮾி㒔༓௦⏣༊
13.

Han DH, Hong I, Choi JE, Park P, Baek JY, Park H, Ide S, Mishina M, Ikeda K, Kaang BK.
Abolished ketamine effects on medial prefrontal cortex neurons in GluN2D knockout mice.
International Conference KSMCB 2022. 2022.9.28㹼9.30

34thInternational Convention Center(ICC), Jeju, Korea
14. ྂ⏣ᓥᾈᏊ. ⤖⠇ᛶ㌾໬⑕࡟క࠺⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ⑕࡬ࡢ⾜ື⒪ἲ࡟ࡼࡿຠᯝ࡜࣓࢝
ࢽࢬ࣒ࡢゎ᫂. ➨ 10 ᅇ᪥ᮏ⤖⠇ᛶ㌾໬⑕Ꮫ఍. 2022.9.18⡿Ꮚࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮, 㫽ྲྀ┴⡿Ꮚᕷ15.

஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯. ⥺⹸㸦C. elegans㸧࡟࠾ࡅࡿ࢜ࣆ࢜࢖ࢻ౫Ꮡᙧᡂ.

2022 ᖺᗘ࢔

ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ ྜྠᏛ⾡⥲఍. 2022.9.9 ௝ྎᅜ㝿ࢭࣥࢱ࣮, ᐑᇛ┴௝ྎᕷ
16.

ᒣᓊឡᐇࠊ஭ᡭ⪽୍㑻ࠊụ❑⤖Ꮚࠊ୕ရᫀ⨾ࠊụ⏣࿴㝯. NMDA ཷᐜయ GluN2D Ḟᦆ࣐࢘ࢫ࡟࠾ࡅࡿ(2R, 6R)-ࣄࢻࣟ࢟ࢩࣀࣝࢣࢱ࣑ࣥࡢᣢ⥆ⓗᢠ࠺ࡘຠᯝࡢᾘኻ.
ࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ 2022 ᖺᗘⱝᡭᨭ᥼ᢏ⾡ㅮ⩦఍.
ࡕ,ឡ▱┴ྡྂᒇᕷ

－

－

ඛ➃ࣔࢹ

2022.8.31 ࢘࢖ࣥࢡ࠶࠸

17.

delta

᳃ᒇ⏤⣖ࠊ➟ཎዲஅࠊ⸨஭⚽᫂ࠊ㛗℩༤ࠊ஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯ࠊ᭮Ⰻ୍㑻.

࢜ࣆ࢜࢖ࢻཷᐜయసື⸆ KNT-127 ࡢᢠ࠺ࡘస⏝࡟࠾ࡅࡿ mu ࢜ࣆ࢜࢖ࢻཷᐜయࡢᙺ๭ࡢ
ゎ᫂.

ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ 2022 ᖺᗘⱝᡭᨭ᥼ᢏ⾡ㅮ⩦఍.

2022.8.31

࢘࢖ࣥࢡ࠶࠸ࡕ, ឡ▱┴ྡྂᒇᕷ18.

୍℩ᏹࠊྡྂ㸦ᒾୗ㸧⏤ెࠊ≟㣫㥴ᘺࠊཎ᛭ࠊ᳃ᒇ⏤⣖ࠊụ⏣࿴㝯. ࢽࢥࢳࣥ࡟ࡼࡿ
ࢳࣟࢩࣥỈ㓟໬㓝⣲άᛶ࠾ࡼࡧࢱࣥࣃࢡ㉁㔞ไᚚᶵᵓࡢゎᯒ. බ┈㈈ᅋἲேႚ↮⛉Ꮫ◊✲㈈ᅋ ➨ 36 ᅇ௧࿴ 3 ᖺᗘຓᡂ◊✲Ⓨ⾲఍. 2022.7.21 ி⋤ࣉࣛࢨ࣍ࢸࣝ, ᮾி㒔᪂ᐟ༊19.

஭ᡭ⪽୍㑻ࠊ⸨⏣㞞௦ࠊụ⏣࿴㝯.

ࢻࣃ࣑ࣥ㛵㐃㑇ఏᏊᨵኚ࣐࢘ࢫࢆ⏝࠸ࡓࢽࢥࢳࣥ

౫Ꮡ࡜⾜ືႴⒷࡢゎᯒ. බ┈㈈ᅋἲேႚ↮⛉Ꮫ◊✲㈈ᅋ ➨ 36 ᅇ௧࿴ 3 ᖺᗘຓᡂ◊✲Ⓨ⾲఍.
20.

2022.7.21 ி⋤ࣉࣛࢨ࣍ࢸࣝ, ᮾி㒔᪂ᐟ༊す⃝኱㍜ࠊ㛗㇂ᕝ‽Ꮚࠊụ⏣࿴㝯.

ࢽࢥࢳࣥ➼≀㉁౫Ꮡ⬤ᙅᛶ࣭㔜⑕ᗘಶேᕪ࡟࠾ࡅ

ࡿ࢔ࣝࢥ࣮ࣝ௦ㅰ㛵㐃㑇ఏᏊከᆺࡢ㛵୚. බ┈㈈ᅋἲேႚ↮⛉Ꮫ◊✲㈈ᅋ ➨ 36 ᅇ௧࿴
3 ᖺᗘຓᡂ◊✲Ⓨ⾲఍. 2022.7.21 ி⋤ࣉࣛࢨ࣍ࢸࣝ, ᮾி㒔᪂ᐟ༊
21.

Kotajima-Murakami H, Hagihara H, Sato A, Hagino Y, Tanaka M, Katoh Y, Nishito Y, Takamatsu
Y, Uchino S, Miyakawa T, Ikeda K.

Exposure to GABAA receptor antagonist picrotoxin in

pregnant mice causes autism-like behaviors and aberrant gene expression in offspring.
NEURO2022.

2022.7.2 Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮ࠊᐅ㔝‴ᕷ❧య⫱㤋ࠊࣛࢢࢼ࣮࢞

ࢹࣥ࣍ࢸࣝ, Ἀ⦖┴ᐅ㔝‴ᕷ
22.

Nishizawa D, Nagashima S, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Hayashida M, Ikeda K.
Association of a single nucleotide polymorphism rs12496846 in the C3orf20 gene region,
identified to be associated with postoperative analgesia after mandibular sagittal split ramus
osteotomy, with postoperative analgesia after major abdominal surgery and C3orf20 gene
expression in the brain.
6.13

23.

Virtual33rd CINP

orld Congress of Neuropsychopharmacology. 2022.6.9㹼

Taipei, Taiwan

Soeda M, Ohka S, Nishizawa D, Hasegawa J, Nakayama K, Ebata Y, Fukuda K, Ikeda K.
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associatedwith phantom tooth pain. 33rd CINP
2022.6.9㹼6.13

24.

Virtualorld Congress of Neuropsychopharmacology.

Taipei, Taiwan

Fujita M, Ochiai Y, Hagino Y, Kobayashi K, Pavey G, Dean B, Ikeda K. Involvement ofmuscarinic receptors for psychomotor hyperactivity in dopamine deficient mice. 33rd CINP
orld Congress of Neuropsychopharmacology. 2022.6.9㹼6.13 Virtual

25.

Taipei, Taiwan

Moriya Y, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS,
Uhl GR, Sora I. A role for the mu opioid receptor in the antidepressant effects of a delta opioid
receptor agonist KNT-127. 33rd CINP

orld Congress of Neuropsychopharmacology.

－－

2022.6.9㹼6.13
26.

VirtualTaipei, Taiwan

Kotajima H, Takano A, Hirakawa S, Ogai Y, Funada D, Tanibuchi Y, Ban E, Kikuchi M,
Tachimori H, Maruo K, Kawashima T, Tomo Y, Sasaki T, Oi H, Matsumoto T, Ikeda K.
Ifenprodil for the treatment of methamphetamine use disorder: An exploratory, randomized,
double-blind, placebo-controlled trial. 33rd CINP

orld Congress of

Neuropsychopharmacology. 2022.6.9㹼6.13 Virtual
27.

Taipei, Taiwan

Ohi K, Nishizawa D, Sugiyama S, Takai K, Fujikane D, Kuramitsu A, Hasegawa J, Soda M,
Kitaichi K, Hashimoto R, Ikeda K, Shioiri T. Cognitive performances across individuals at highgenetic risk for schizophrenia, high genetic risk for bipolar disorder, and low genetic risks: a

28.

combined polygenic risk score approach. 33rd CINP

orld Congress of

Neuropsychopharmacology. 2022.6.9㹼6.13 Virtual

Taipei, Taiwan

Ohka S, Yamada S, Kinoshita H, Fukui Y, Hasegawa J, Nishizawa D, Fukushi S, Ebihara H,
Ikeda K. Effect of heparan sulfate glucosamine 3-O-sulfotransferase 4 on SARS-CoV-2
infection. 33rd CINP

orld Congress of Neuropsychopharmacology.

2022.6.9㹼6.13

VirtualTaipei, Taiwan
29.

Ochiai Y, Fujita M, Hagino Y, Kobayashi K, Okiyama R, Takahashi K, Ikeda K. The
therapeutic effects of 5-HT1A receptor agonist on the psychomotor hyperactivity in dopaminedeficient mice. 33rd CINP
Virtual30.

orld Congress of Neuropsychopharmacology. 2022.6.9㹼6.13

Taipei, Taiwan

Ide S, Kunitomo H, Iino Y, Ikeda K. Addiction-like behavior of morphine via the opioid-likereceptor NPR-17 in Caenorhabditis elegans. 33rd CINP

orld Congress of

Neuropsychopharmacology. 2022.6.9㹼6.13 Virtual

Taipei, Taiwan

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 5 ௳㸧
1.

ụ⏣࿴㝯.

౫Ꮡ⑕ࡢᇶ♏▱㆑ ㅮ₇ୡ⏣㇂༊❧ඵᖭᒣᑠᏛᰯ⸆≀஘⏝㜵Ṇㅮ⩦఍.

2022.12.15 ඵᖭᒣᑠᏛᰯ, ᮾி㒔ୡ⏣㇂༊
2.

ụ⏣࿴㝯.

⬻⛉Ꮫศ㔝ࡢ⏘Ꮫ㐃ᦠ ㅮ₇࣒࣮ࣥࢩࣙࢵࢺᆺ◊✲㛤Ⓨ஦ᴗ ┠ᶆ㸯 ◊✲㛤Ⓨࣉࣟࢪ࢙ࢡࢺ ㌟యⓗ⬟ຊ࡜▱ぬ⬟ຊࡢᣑᙇ࡟ࡼࡿ㌟యࡢไ⣙࠿ࡽࡢゎᨺ බ㛤࣮࣡ࢡࢩࣙࢵࣉࠕTrusted BrainTech / BMI ࡢᐇ⌧࡟ྥࡅ࡚ࠖ. 2022.10.28 ࢔ࢵࢺࣅࢪࢿࢫ
ࢭࣥࢱ࣮ᮾி㥐ඵ㔜Ὢ㏻ࡾ,
3.

ụ⏣࿴㝯.

ᮾி㒔୰ኸ༊

࢔ࢹ࢕ࢡࢩࣙࣥࡢᇶ♏▱㆑࡜᭱㏆ࡢ◊✲࡟ࡘ࠸࡚ ㅮ₇᪥ᮏࢣ࣑ࣇ࢓ᰴ

ᘧ఍♫ㅮ₇఍. 2022.9.21 ᪥ᮏࢣ࣑ࣇ࢓ᰴᘧ఍♫ ๰⸆◊✲ᡤ, ᇸ⋢┴୕㒓ᕷ
4.

ụ⏣࿴㝯.

ࡀࢇ⑊③⦆࿴࡟᭷⏝࡞࢜ࣆ࢜࢖ࢻ㙠③⸆࡟㛵ࡍࡿከゅⓗ▱ぢ ㅮ⩏ᇽ኱Ꮫ኱Ꮫ㝔≉ูㅮ⩏. 2022.9.13

ࣜ࢔ࣝࢱ࢖࣒࢜ࣥࣛ࢖ࣥ㓄ಙ
－

－

㡰ኳ

5.

ụ⏣࿴㝯.

ࢸ࣮࣮࣓ࣛ࢖ࢻࡢ࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇࡟ྥࡅ࡚ ㅮ₇ࣝࢥ࣮ࣝ⮫ᗋ᠓ヰ఍㸫TALK㸫.

➨ 40 ᅇᮾி࢔

2022.6.23 ⚄⏣ࢫࢡ࢚࢔࢝ࣥࣇ࢓ࣞࣥࢫ,ᮾி㒔༓௦⏣༊㸦ࣁ࢖ࣈࣜࢵࢻ㛤ദ㸧IV. ≉グ஦㡯㸺ཷ㈹㸼
1.

ῧ⏣ⴌ㸦2022 ᖺ 7 ᭶㸧JSNP Excellent Presentation Award for CINP 2022 ཷ㈹2.

ⴠྜ㑳⣖Ꮚ㸦2022 ᖺ 6 ᭶㸧CINP 2022 Student Encouragement Award ཷ㈹㸺௚ᶵ㛵࡬ࡢ༠ຊ㸼1.

ụ⏣࿴㝯㸦2019 ᖺ 11 ᭶-⌧ᅾ㸧ᮾி㒔࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇᥎㐍ጤဨ఍ጤဨ㛗2.

ụ⏣࿴㝯㸦2017 ᖺ 12 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ㞴἞ᛶ⑌ᝈᐇ⏝໬◊✲஦ᴗ ㄢ㢟ホ౯ጤဨ఍ጤဨ
3.

ụ⏣࿴㝯㸦2017 ᖺ 1 ᭶-⌧ᅾ㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ⸆஦࣭㣗ရ⾨⏕ᑂ㆟఍⮫᫬ጤဨ4.

ụ⏣࿴㝯㸦2017 ᖺ 1 ᭶-⌧ᅾ㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ┘どᣦᑟ࣭㯞⸆ᑐ⟇ㄢ౫Ꮡᛶ⸆≀᳨ウ఍ᵓᡂဨ5.

ụ⏣࿴㝯㸦2016 ᖺ 4 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓࣉࣟࢢ࣒ࣛ࢜ࣇ࢕ࢧ࣮

6.

ụ⏣࿴㝯㸦2015 ᖺ 12 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓㄢ㢟ホ౯ጤဨ఍ጤဨ

7.

ụ⏣࿴㝯㸦2014 ᖺ 10 ᭶-2026 ᖺ 9 ᭶㸧᪥ᮏᏛ⾡఍㆟㐃ᦠ఍ဨ㸦࢔ࢹ࢕ࢡࢩࣙࣥศ⛉఍ጤဨ㛗㸸2017 ᖺ-⌧ᅾ ᇶ♏་Ꮫጤဨ఍ጤဨ㸸2021-⌧ᅾ, ⬻࡜ࡇࡇࢁศ⛉఍ᖿ஦㸸20152020, ጤဨ㸸2015 ᖺ-⌧ᅾ ⚄⤒⛉Ꮫศ⛉఍ጤဨ㸸2017 ᖺ-⌧ᅾ㸧8.

ụ⏣࿴㝯㸦2019 ᖺ 10 ᭶-⌧ᅾ㸧៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊9.

ụ⏣࿴㝯㸦2014 ᖺ 4 ᭶-⌧ᅾ㸧᪂₲኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉࣭ᐈဨᩍᤵ

ᐈဨᩍᤵ

10. ኱ᒸ㟼⾰㸦2017 ᖺ-⌧ᅾ㸧ᩥ⛉┬⛉Ꮫᢏ⾡࣭Ꮫ⾡ᑂ㆟఍ ⏕࿨೔⌮࣭Ᏻ඲㒊఍㑇ఏᏊ⤌᥮࠼ᢏ⾡➼ᑓ㛛ጤဨ఍ᑓ㛛ጤဨ㸺Ꮫ఍άື㸼
1.

ụ⏣࿴㝯 ᪥ᮏ⚄⤒⛉ᏛᏛ఍㸦఍ဨ㸸1996-⌧ᅾࠊࣉࣟࢢ࣒ࣛጤဨ㸸2020, 2021,2022㸧

2.

ụ⏣࿴㝯 ᪥ᮏศᏊ⏕≀Ꮫ఍㸦఍ဨ㸸1994-⌧ᅾ㸧

3.

ụ⏣࿴㝯 ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍㸦఍ဨ㸸2001-⌧ᅾࠊホ㆟ဨ㸸2004-⌧ᅾࠊ50 ࿘ᖺグᛕ஦ᴗ࣮࣡࢟ࣥࢢࢢ࣮ࣝࣉጤဨ㛗㸸2018-2020ࠊ㈈ົጤဨ㛗㸸2020-2022)
－ 1－

4.

ụ⏣࿴㝯 㙠③⸆࣭࢜ࣆ࢜࢖ࢻ࣌ࣉࢳࢻ◊✲఍㸦఍ဨ㸸1996-⌧ᅾࠊୡヰே㸸2006-⌧ᅾ㸧

5.

ụ⏣࿴㝯 ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍(JMSAAS) (ᪧࢽࢥࢳ࣭ࣥ⸆≀౫Ꮡ◊✲ࣇ࢛࣮࣒ࣛࠊ᪥ᮏ࢔ࣝࢥ࣮ࣝ⢭⚄་Ꮫ఍ࠊ᪥ᮏ౫Ꮡ⚄⤒⢭⚄⛉Ꮫ఍ࠊ᪥ᮏ࢔ࣝࢥ࣮
࣭ࣝ⸆≀་Ꮫ఍) (఍ဨ㸸2002-⌧ᅾࠊᏛ⾡ホ㆟ဨ㸸2005-⌧ᅾࠊ⌮஦㸸2008-2022ࠊᗈሗጤဨ㛗㸸2012-2020ࠊᏛ⾡⥲఍ᢸᙜጤጤဨ㛗㸸2020-2022ࠊᑗ᮶ᵓ᝿ጤဨ㛗㸸2021-⌧ᅾ)

6.

ụ⏣࿴㝯 ᪥ᮏ⑊③Ꮫ఍㸦఍ဨ㸸2008-⌧ᅾ㸧

7.

ụ⏣࿴㝯 ᪥ᮏ⦆࿴་⒪⸆Ꮫ఍㸦఍ဨ㸸2009-⌧ᅾ㸧

8.

ụ⏣࿴㝯 ᪥ᮏ⸆⌮Ꮫ఍㸦఍ဨ㸸2009-⌧ᅾࠊᏛ⾡ホ㆟ဨ㸸2017-⌧ᅾࠊ௦㆟ဨ㸸20202024ࠊ⸆⌮Ꮫ࢚ࢹࣗࢣ࣮ࢱ࣮㸸2020-2024㸧

9.

ụ⏣࿴㝯 ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍㸦఍ဨ㸸2011-⌧ᅾ㸧

10. ụ⏣࿴㝯 ᪥ᮏ࣌࢖ࣥࢡࣜࢽࢵࢡᏛ఍㸦ホ㆟ဨ㸸2021-⌧ᅾ㸧
11. ụ⏣࿴㝯 ᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ㸦ホ㆟ဨ㸸2012-⌧ᅾࠊᑗ᮶ᵓ᝿ጤဨ㸸2018-⌧ᅾࠊ㐠Ⴀጤဨ㸸2020-⌧ᅾࠊ⏘Ꮫ㐃ᦠㅎၥጤဨ఍ጤဨ㛗㸧12. ụ⏣࿴㝯 Society for Neuroscience (USA) (SfN) (఍ဨ㸸1996-⌧ᅾ)
13. ụ⏣࿴㝯 International Brain Research Organization (IBRO) (఍ဨ㸸1996-⌧ᅾࠊCJK ጤဨ㸸
2017-⌧ᅾ)
14. ụ⏣࿴㝯 International Narcotics Research Conference (INRC) (఍ဨ㸸1996-⌧ᅾ)
15. ụ⏣࿴㝯 International Drug Abuse Research Society (IDARS) (఍ဨ㸸2006-⌧ᅾ)
16. ụ⏣࿴㝯 College on Problems of Drug Dependence (CPDD) (఍ဨ㸸2006-⌧ᅾ)
17. ụ⏣࿴㝯 International College of Neuropsychopharmacology (CINP) (఍ဨ㸸2010-⌧ᅾࠊConstitution and By-law Committee Member㸸2014-⌧ᅾࠊCredentials and Membership
Committee Chair㸸2018-⌧ᅾࠊFinance and Budget Committee Chair㸸2008-⌧ᅾࠊTreasurer㸸
2018-2022ࠊPresident-elect㸸2022-⌧ᅾ)
18. ụ⏣࿴㝯 Asian College of Neuropsychopharmacology (AsCNP) (఍ဨ㸸2009-⌧ᅾࠊCouncilor㸸2017-⌧ᅾࠊPresident㸸2019-2020ࠊPast-President㸸2021-2022)
19. ụ⏣࿴㝯 American College of Neuropsychopharmacology (ACNP) (Member㸸2014-2020ࠊ
Fellow㸸2021-⌧ᅾ)
20. ụ⏣࿴㝯 International Association for the Study of Pain (IASP) (Member㸸2015-⌧ᅾ)
21. ụ⏣࿴㝯 Cochrane (Member㸸2015-⌧ᅾ)
22. ஭ᡭ⪽୍㑻 ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ホ㆟ဨ

23. ஭ᡭ⪽୍㑻 ᪥ᮏ⸆⌮Ꮫ఍ Ꮫ⾡ホ㆟ဨ
－－24. ➟஭ៅஓ ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ㸦2012-⌧ᅾ㸧
25. ➟஭ៅஓ ᪥ᮏ౫Ꮡ⚄⤒⢭⚄⛉Ꮫ఍ホ㆟ဨ

26. す⃝኱㍜ ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ㸦2012-⌧ᅾ㸧
27. す⃝኱㍜ ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍

Ꮫ⾡ホ㆟ဨ㸦2020-⌧ᅾ㸧

28. ኱ᒸ㟼⾰ ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ㸦2021-⌧ᅾ㸧
29. ྂ⏣ᓥᾈᏊ ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ホ㆟ဨ㸦2021-⌧ᅾ㸧

30. ⴗ㔝ὒᏊ ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ㸦2012-2022㸧ຌປ఍ဨ㸦2022-⌧ᅾ㸧㸺Ꮫ⾡㞧ㄅ⦅㞟㸼1.

ụ⏣࿴㝯 Biological Psychiatry: Global Open Science, Editorial Board Member (2020-present)2.

ụ⏣࿴㝯 Neuropsychopharmacology Reports, Associate Editor (2018-present)3.

ụ⏣࿴㝯 Alcoholism: Clinical4.

ụ⏣࿴㝯 Journal of Drug and Alcohol Research, Associate Editor Board Member (2012-

Experimental Research, Field Editor (2017- present)

present)5.

ụ⏣࿴㝯 Addiction Genetics, Editorial Advisory Board Member (2012-present)6.

ụ⏣࿴㝯 PLoS ONE, Academic Editor (2009-present)7.

ụ⏣࿴㝯 The Open Neuropsychopharmacology Journal, Editorial Advisory Board Member(2008-present)8.

ụ⏣࿴㝯 The Open Pain Journal, Editorial Advisory Board Member (2008-present)－－ࣉࣟࢪ࢙ࢡࢺྡ

ឤᰁไᚚࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 12 ௳㸧
1.

Sadahiro Iwabuchi, Tomohide Tsukahara, Toshitugu Okayama, Masahiro Kitabatake, Hideki
Motobayashi, Shigeyuki Shichino, Tadashi Imafuku, Kenzaburo Yamaji, Kyohei
Miyamoto, Shinobu Tamura, Satoshi Ueha, Toshihiro Ito, Shin-Ichi Murata, Toshikazu
Kondo, Kazuho Ikeo, Yutaka Suzuki, Kouji Matsushima, Michinori Kohara, Toshihiko
Torigoe, Hiroki Yamaue, Shinichi Hashimoto. B cell receptor repertoire analysis from autopsy
samples of COVID-19 patients. Frontiers Immunology. 20230223. 14:1034978. (doi:10.3389/fimmu.2023.1034978.)2.

Takuro Uchida, Michio Imamura, C Nelson Hayes, Yosuke Suehiro, Yuji Teraoka, Kazuki Ohya,
Hiroshi Aikata, Hiromi Abe-Chayama, Yuji Ishida, Chise Tateno, Yuichi Hara, Keisuke Hino,
Toru Okamoto, Yoshiharu Matsuura, Hideki Aizaki, Kenjiroake, Michinori Kohara, T Jake

Liang, Shiro Oka, Kazuaki Chayama. HBV with precore and basal core promoter mutations
exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver
chimeric mice. Hepatology. 20230313. (doi: 10.1097/HEP.0000000000000335.)
2.

Naoya Otsubo, Tatsuya Fukuda, Hiroko Beppu, Chisato Maki, Fumihiko Yasui, Tomohide
Hanawa, Chise Sugita, Masanori Murakami, Tetsuya Yamada, Michinori Kohara, Sachikoakai.

Reduced antibody response to SARS-CoV-2 in COVID-19 patients with newly diagnosed
diabetes: a retrospective observational study. BMC Endocrine Disorders., 202300116 23(1):5(doi: 10.1186/212902-023-01263-z.)
3.

Takahiro Sanada, Tomoko Honda, Masahiko Higa, Kenzaburo Yamaji, Fumihiko Yasui,
Michinori Kohara. Antibody response to third and fourth BNT162b2 mRNA booster vaccinationsin healthcare workers in Tokyo, Japan. Journal of Infection and Chemotherapy: official journalof the Japan Society of Chemotherapy., 20221227. (doi.org/10.1016/j.jiac.2022.12.012)

4.

Eriko Inuo, Mitsuhiro Miyashita, Fumihiko Yasui, Ken Matsumura, Kentaro Sakashita, Eiji
Hayashi, Masahiro Ono, Shyoji Sugii, Michinori Kohara, Masahiko Saito. Longitudinal changesof SARS-CoV-2 immunoglobulin G and immunoglobulin M in psychiatric disorders withcoronavirus infection. Psychiatry and Clinical Neurosciences. 20221224. 77(2):124-125. (doi:
10.1111/pcn.13513.)

－

－

5.

Takashi Toya, Daichi Sadato, Takahiro Sanada, Tomoko Honda, Yuya Atsuta, Noritaka Sekiya,
Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Yuka Harada, Michinori Kohara, Noriko
Doki. A third dose of COVID-19 mRNA vaccine induces limited humoral response in stem celltransplant recipients who got two vaccine doses before transplant. eJHaem., 20221222.
(doi.org/10.1002/jha2.637)

6.

Osamu Yoshida, Sheikh Mohammad Fazle Akbar, Yusuke Imai, Takahiro Sanada, Kyoko
Tsukiyama-Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Yoshio Tokumoto,
Hayato Hikita, Masataka Tsuge, Masahito Shimizu, Mamun Al Mahtab, Julio Cesar Aguilar,
Gerardo Guillen, Michinori Kohara, Yoichi Hiasa. Intranasal therapeutic vaccine containing
HBsAg and HBcAg for patients with chronic hepatitis B 18 months follow-up results of phase
IIa clinical study. Hepatology Research: the official journal of the Japan Society of Hepatology.,
20221118. (doi.org/10.1111/hepr.13851)

7.

Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto,
Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda,
Tsubasa Munakata, Masahiko Higa, Sakiko Toyama, Risa Kono, Asako Takagi, Yusuke
Matsumoto, Aya Koseki, Kaori Hayashi, Masanori Shiohara, Koji Ishii, Yasushi Saeki, Yasushi
Itoh, Michinori Kohara. An attenuated vaccinia vaccine encoding the severe acute respiratory
syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects
cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe
acute respiratory syndrome coronavirus-2 and its variants. Frontiers in Microbiology., 13, 967019,
20221118. (doi.org/10.3389/fmicb.2022.967019)

8.

Takashi Toya, Yuya Atsuta, Takahiro Sanada, Tomoko Honda, Daichi Sadato, Noritaka Sekiya,
Hiroko Kogure, Sonomi Takakuwa, Daishi Onai, Naoki Shingai, Hiroaki Shimizu, Yuho Najima,
Takeshi Kobayashi, Kazuteru Ohashi, Yuka Harada, Michinori Kohara, Noriko Doki. AttenuatedHumoral Response Against SARS-CoV-2 mRNA Vaccination in Allogeneic Stem Cell
Transplantation Recipients. Cancer Science., B 20220926. (doi.org/10.1111/cas.15603)

9.

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Md
Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito
Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara. Characterization of innate immune
response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model.
Frontiers in Virology., 2, 20220818. (doi.org/10.3389/fviro.2022.926831)

10. Takahiro Sanada, Michinori Kohara. Response to the Letter to the Editor regarding Serologic
survey of IgG against SARS-CoV-2 among hospital visitors without a history of SARS-CoV-2
infection in Tokyo. Journal of Epidemiology., 20220730. (doi.org/10.2188/jea.JE20220202)
11. Yutaro Neriya, Shohei Kojima, Arata Sakiyama, Mai Kishimoto, Takao Iketani, Tadashi
atanabe, Yuichi Abe, Hiroshi Shimoda, Keisuke Nakagawa, Takaaki Koma, Yusuke Matsumoto.
－ 5－

A comprehensive list of the Bunyavirales replication promoters reveals a unique promoter
structure in Nairoviridae differing from other virus families. Scientific Reports., A 12, 1: 1356013560, 20220809. (doi.org/10.1038/s41598-022-17758-z)
12. Masamichi Kimura, Koji Nishikawa, Yosuke Osawa, Jun Imamura, Kenzaburo Yamaji, Kenichi
Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Kouichi Miura, Atsushi Tanaka, Tatsuya
Kanto, Michinori Kohara, Terumi Kamisawa, Kiminori Kimura. ,QKLELWLRQRI&%3ȕ-cateninsignaling ameliorated fibrosis in cholestatic liver disease. Hepatology Communications.
20220720. 6(10):2732-2747. (doi: 10.1002/hep4.2043.)

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 5 ௳㸧1.

Ᏻ஭ᩥᙪ ู෉ ་Ꮫࡢ࠶ࡺࡳ 111ʷ118, 2022

2.

Mohammad Enamul Hoque Kayesh, Ibrahim Khalil, Michinori Kohara, Kyoko TsukiyamaKohara. Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview.
Tropical Medicine and Infectious Disease., 20230103. 8(1):32. (doi:10.3390/tropicalmed8010032.)

3.

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara. Epidemiology
and Risk Factors for Acute Viral Hepatitis in Bangladesh: An Overview. Microorganisms.
20221115. 10(11):2266. (doi: 10.3390/microorganisms10112266.)

4.

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara. Toll-like
Receptor Response to Hepatitis C Virus Infection: A Recent Overview. International Journal of
Molecular Sciences. 20220513. 23(10):5475. (doi: 10.3390/ijms23105475.)

5.

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Michinori Kohara, Kyoko TsukiyamaKohara. In vivo Delivery Tools for Clustered Regularly Interspaced Short Palindromic
Repeat/Associated Protein 9-Mediated Inhibition of Hepatitis B Virus Infection: An Update.
Frontiers Microbiology. 20220701. 13:953218. (doi: 10.3389/fmicb.2022.953218.)II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  1 ௳㸧
1.

Ᏻ஭ᩥᙪࠊఀ⸨㟹ࠊᒣᆅ㈼୕㑻ࠊᒣᮏ┤ᶞࠊᯇᮏ♸௓ࠊ┿⏣ᓫᘯࠊᮏ⏣ᬛᏊࠊᲷ᪉⩼ࠊ▼ᇉᏹோࠊ௰ᒣ⨾ἋᏊࠊ㧗ᮌᮅᏊࠊ▼஭ᾈྖࠊᑠཎ㐨ἲ. COVID-19 ࣡ࢡࢩࢽ࢔࢘࢖ࣝࢫ࣋ࢡ
ࢱ࣮࣡ࢡࢳࣥࡢ㛤Ⓨ. ➨ 69 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ࠊᐑᇛࠊ2022/5/18㹼2022/5/20㸦ࢩ࣏ࣥࢪ࣒࢘ࠊᣍᚅㅮ₇㸧－ 6－ࡑࡢ௚ 㸦ィ 16 ௳㸧⮬⏤ᥖ㍕
1.

ᒣ᰿኱඾, ᯘඃ㔛,ᕷ⫱௦ ⬡⫫㓟୙㣬࿴໬㓝⣲ࢆ௓ࡋࡓ C ᆺ⫢⅖࢘࢖ࣝࢫ」〇࡜ࣇ࢙ࣟࢺ࣮ࢩࢫࡢไᚚ ➨ 347 ᅇ⬡⁐ᛶࣅࢱ࣑ࣥ⥲ྜ◊✲ጤဨ఍

2022/12/16 ᮾி㎰ᴗ኱Ꮫ

/ᮾி㒔
2.

Ᏻ஭ᩥᙪ, ᯇᮏ♸௓, ▼ᇉᏹோ, ௰ᒣ⨾ἋᏊ, ᒣᮏ┤ᶞ, ┿⏣ᓫᘯ, ᒣᆅ㈼୕㑻, Cong
Thanh Nguyen, ᮏ⏣ᬛᏊ, ໭ᕝၿ⣖, ఀ⸨㟹, ᑠཎ㐨ἲ 㧗ᗘᙅẘ໬࣡ࢡࢩࢽ࢔࢘࢖ࣝࢫ
࣋ࢡࢱ࣮Dis ࢆ⏝࠸ࡓ COVID-19 ࣡ࢡࢳࣥࡢ஺ᕪ཯ᛂᛶ࡜㛗ᮇච␿ᣢ⥆ຠᯝࡢ᳨ウ ➨ 26ᅇ᪥ᮏ࣡ࢡࢳࣥᏛ఍Ꮫ⾡㞟఍ 2022/11/26㹼2022/11/27

3.

㤶ᕝ┴┴Ẹ࣮࣍ࣝ/㤶ᕝ┴㤶ᕝᕷFumihiko Yasui, Yusuke Matsumoto, Naoki Yamamoto, Takahiro Sanada, Tomoko Honda,
Tsubasa Munakata, Yasushi Itoh, Michinori Kohara

Infectivity and pathogenisity of DARS-CoV-2 beta variant in wild-type mice ➨ 69 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2022/11/13㹼
2022/11/15
4.

ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ

Tsubasa Munakata and Michinori Kohara. CLEC1B is a novel host factor that facilitates hepatitis B
virus infection. ➨ 㻢㻥 ᅇ᪥ᮏ䜴䜲䝹䝇Ꮫ఍Ꮫ⾡㞟఍ 2022/11/13㹼2022/11/15 ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ

5.

Tomoko Honda, Sakiko Toyama, Yusuke Matsumoto, Takahiro Sanada, Fumihiko Yasui, Takashi
Miyazaki, Takashi Kamishita, Natsumi Kodaka, Michinori Kohara

Single dose intranasal

inoculation of SARS-CoV-2 spike protein with mucoadhesive polymer enhances the mucosal andsystemic immunogenicity ➨ 69 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍

2022/11/13㹼2022/11/15

ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ
6.

ᯇᮏ♸௓ࠊ┿⏣ᓫᘯࠊᏳ஭ᩥᙪࠊᑠཎ㐨ἲ. ᪂つࣄࢺ ACE2 Ⓨ⌧࢔ࢹࣀ࢘࢖ࣝࢫ࣋ࢡࢱ࣮
ࢆ⏝࠸ࡓ COVID-19 ࣐࢘ࢫࣔࢹࣝࡢ☜❧. ➨ 69 ᅇ᪥ᮏ䜴䜲䝹䝇Ꮫ఍Ꮫ⾡㞟఍ 2022/11/13
㹼2022/11/15 ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ

7.

ᒣᮏ┤ᶞࠊబ⸨ᝆ௓ࠊᮧୖ࿘Ꮚࠊ⏣୰㟹ேࠊཎᓥ⚽ྜྷࠊᑠཎ㐨ἲ. ࣏ࣜ IC ࢆᦚ㍕ࡋࡓ⫢ᐇ㉁⣽⬊ᣦྥᛶ⮬↛ච␿ㄏᑟ๣࡟ࡼࡿ B ᆺ⫢⅖࢘࢖ࣝࢫ cccDNA ῶᑡᶵᗎࡢゎᯒ. ➨ 㻢㻥 ᅇ᪥ᮏ䜴䜲䝹䝇Ꮫ఍Ꮫ⾡㞟఍ 2022/11/13㹼2022/11/15

8.

ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ㧗ᮌᮅᏊࠊᑽᏊ㇏ࠊᒣ᰿኱඾ࠊ࢟ࢱࣈ࣭ࣈࢩࣗࣛࠊᚨỌඃᏊࠊ࢔࣮࣒ࢻ࣭࢚࣭ࣝࢦࣁ࣮ࣜࠊᑠཎ 㐨ἲࠊᑠཎ ᜤᏊ. C ᆺ⫢⅖࢘࢖ࣝࢫ㸦㑇ఏᏊᆺ 4a)ࡢ 3'UTR ෆ poly(U)㓄ิࡢ」〇ไᚚ࡟࠾ࡅࡿᙺ๭. ➨ 㻢㻥 ᅇ᪥ᮏ䜴䜲䝹䝇Ꮫ఍Ꮫ⾡㞟఍ 2022/11/13㹼2022/11/15

ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ9.

㧗ᮌᮅᏊࠊᑽᏊ㇏ࠊᒣ᰿኱඾ࠊ࢟ࢱࣈ࣭ࣈࢩࣗࣛࠊᚨỌඃᏊࠊ࢔࣮࣒ࢻ࣭࢚࣭ࣝࢦࣁࣜ
࣮ࠊᑠཎ 㐨ἲࠊᑠཎ ᜤᏊ. C ᆺ⫢⅖࢘࢖ࣝࢫ㸦㑇ఏᏊᆺ 4a)ࡢ 3'UTR ෆ poly(U)㓄ิ
ࡢ」〇ไᚚ࡟࠾ࡅࡿᙺ๭. ➨ 81 ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ 2022/9/29㹼2022/10/1 ࣃࢩࣇ࢕ࢥᶓ὾/⚄ዉᕝ┴ᶓ὾ᕷ

－ 7－

10. Ჷ᪉⩼, ᑠཎ㐨ἲ

CLEC1B is a novel host factor that facilitates hepatitis B virus infection➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ኱఍ 2022/11/9㹼2022/11/11 ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ
11. Kenzaburo Yamaji, Yuko Tokunaga, Sadahiro Iwabuchi, Shinichi Hashimoto, Daisuke Yamane,
Sakiko Toyama, Bouchara Kitab, Kyoko Tsukiyama-Kohara, Michinori Kohara $&%3ȕcatenin signaling

inhibitor, PRI-724 ameliorates NASH-induced liver fibrosis and disorder

AASLD ⡿ᅜ⫢⮚Ꮫ఍ The Liver Meeting 2022 2022/11/4㹼2022/11/8

ashington,DC/USA࢜ࣥࣛ࢖ࣥ
12. Tomoko Honda, Sakiko Toyama, Yusuke Matsumoto, Takahiro Sanada, Fumihiko Yasui, Takashi
Miyazaki, Takashi Kamishita, Natsumi Kodaka, Michinori Kohara

Co-administration of a

mucoadhesive polymer with purified spike protein of SARS-CoV-2 induces robust mucosal andsystemic immune responses

2022 ISV annual congress

2022/9/18㹼2022/9/20

uebec

City Convention Centre/ uebec City, Canada
13. Naoki Yamamoto, Yusuke Sato, Shuko Murakami, Yasuhiro Tanaka, Hideyoshi Harashima,
Michinori Kohara

Hepatic

parenchymal cell-topic innate immune modulator using

poly(I:C) reduced HBV cccDNA in the liver of chimeric mice International HBV meeting
2022

2022/9/18㹼2022/9/22

14. ᯇᮏ♸௓࢜ࣥࣛ࢖ࣥ

A comprehensive list of the replication promoters of segmented negative-sense RNA

viruses indicates virs family-specific RNA synthesis mechanisms ➨ 23 ᅇ᪥ᮏ RNA Ꮫ఍
2022/7/20㹼2022/7/22 ࡳࡸࡇࡵࡗࡏ/ி㒔ᕷ
15. ᒣᮏ┤ᶞࠊ⏣୰㟹ேࠊᑠཎ㐨ἲ. ࣏ࣜ IC ࢆᦚ㍕ࡋࡓ⫢ᐇ㉁⣽⬊ᣦྥᛶ⬡㉁ࢼࣀ⢏Ꮚࢆ฼⏝ࡋࡓ B ᆺ⫢⅖࢘࢖ࣝࢫ cccDNA ไᚚࡢ᳨ウ. ➨ 26 ᅇ᪥ᮏ⫢⮚Ꮫ఍኱఍ JDDW2022ࠊ
2022/10/27㹼2022/10/30㸦ࢩ࣏ࣥࢪཱྀ࣒࢘㢌Ⓨ⾲㸧⚟ᒸᅜ㝿఍㆟ሙ/⚟ᒸ┴⚟ᒸᕷ
16. እᒣဏ⣖Ꮚࠊᮏ⏣ᬛᏊࠊᒣᆅ㈼୕㑻ࠊᒾῡ⚞ᘯࠊᶫᮏ┿୍ࠊᐑᓮ㝯ࠊᑠཎ㐨ἲ. ᫬✵㛫ⓗ㑇ఏᏊⓎ⌧ゎᯒࢆ⏝࠸ࡓ SARS-CoV-2 ࢫࣃ࢖ࢡࢱࣥࣃࢡ㉁࡟ᑐࡍࡿ⤒㰯࣡ࢡࢳࣥࡢච
␿ᛂ⟅ㄏᑟᶵᗎࡢゎᯒ. ➨ 68 ᅇ᪥ᮏ⑓⌮Ꮫ఍⛅ᮇ≉ู⥲఍ࠊᒾᡭࠊ2022/11/17㹼
2022/11/18 ┒ᒸᕷẸᩥ໬࣮࣍ࣝ ኱࣮࣭࣍ࣝ࢔࢖࣮ࢼᒾᡭ┴Ẹ᝟ሗ஺ὶࢭࣥࢱ࣮/ᒾᡭ┴┒ᒸᕷIII. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯－－ࣉࣟࢪ࢙ࢡࢺྡ

࢘࢖ࣝࢫឤᰁࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

akako Miwatashi, Minori Ishida, Ayako Takashino, Kyousuke Kobayashi, Midori Yamaguchi,
Hiroshi Shitara, Satoshi Koike. Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal
Mice. Journal of Virology., A 96,15: e0056122, 20220810. (doi.org/10.1128/jvi.00561-22)

2.

Kanami Tamura, Mai Kohnoe, Ayako Takashino, Kyousuke Kobayashi, Satoshi Koike, Lovkesh
Karwal, Shigeru Fukuda, Fue Vang, Subash C Das, Hansi J Dean. TAK- 021, an inactivatedEnterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups
in human scavenger receptor B2 transgenic mice. Vaccine., B e40(24) : 3330- 3337. 20220429.
(doi.org/10.1016/j.vaccine.2022.04.064) PMID: 35501179㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 0 ௳㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
࠙ᅜ㝿Ꮫ఍࣭࣏ࢫࢱ࣮ࠚ
1.

K. Kobayashi, N. Nomura, A. Ohkubo, T. Nishizawa, S. Koike Two nucleotide mutations in
IRES stem-loop IV define neuron-specific EV-A71 proliferation The 20th Awaji International
Forum on Infection and Immunity㸦2022 ᖺ 9 ᭶ 8 ᪥ ࢜ࣥࣛ࢖ࣥ㛤ദ㸧－－

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯1.

ᑠụᬛ 㸸ᮾ໭኱Ꮫ⸆Ꮫ㒊 ឤᰁ⑕Ꮫㅮ⩏㸦2022 ᖺ 10 ᭶ 20 ᪥㸧2.

ᑠụᬛ 㸸⋊༠་⛉኱Ꮫ ᚤ⏕≀Ꮫㅮ⩏㸦2022 ᖺ 12 ᭶ 2 ᪥㸧

3.

ᑠụᬛ 㸸㔠ἑ኱Ꮫ་⸆ಖ೺Ꮫᇦ་Ꮫ㢮 ࠕ࢚ࣥࢸࣟ࢘࢖ࣝࢫࡢ⑓ཎᛶࠖࡢㅮ⩏㸦2023
ᖺ 2 ᭶ 14 ᪥㸧

4.

ᑠᯘ㒓௓㸸᪂⯆࢚ࣥࢸࣟ࢘࢖ࣝࢫឤᰁ⑕ࡢ㔜⑕໬࡟㛵ࢃࡿᐟ୺ᅉᏊࡢゎᯒ Ṋ⏣⛉Ꮫ᣺⯆㈈ᅋ ࣁ࢖ࣜࢫࢡ᪂⯆ឤᰁ⑕◊✲ຓᡂ5.

ᑠᯘ㒓௓㸸ዪᏊ୰㧗⏕ኟࡢᏛᰯ 2022ࠥ⛉Ꮫ࣭ᢏ⾡࣭ே࡜ࡢฟ఍࠸ࠥ ࢟ࣕࣜ࢔┦ㄯ఍
㸦2022 ᖺ 8 ᭶ 7 ᪥࢜ࣥࣛ࢖ࣥ㛤ദ㸧－1－ࣉࣟࢪ࢙ࢡࢺྡ

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ཎ⏣㧗ᖾ

 ᖺࠥ ᚨᓥ኱Ꮫ኱Ꮫ㝔 ་ṑ⸆Ꮫ◊✲㒊 ║⛉Ꮫศ㔝 ᐈဨᩍᤵ ᖺࠥ 㜵⾨་⛉኱Ꮫᰯ ෌⏕Ⓨ⏕Ꮫㅮᗙ 㠀ᖖ໅ㅮᖌࠊ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉ ║⛉Ꮫศ㔝 㠀ᖖ໅ㅮᖌࠊᮾி㒔❧ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮║⛉ 㠀ᖖ໅་ᖌ
ㅮ⩏ࢸ࣮࣐ࠕ7KH(<('HYHORSPHQW'LVHDVHV 5HJHQHUDWLRQࠖ
¾

௨ୗࡢᏛ఍άືࢆ⾜ࡗࡓ ᖺ  ᭶  ᪥ ➨  ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍ ࠕᇶ♏◊✲ࠖᗙ㛗➨  ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍ ࢥ࢔࣓ࣥࣂ࣮ࠊࣉࣟࢢ࣒ࣛጤဨ
➨  ᅇ᪥ᮏ║⸆⌮Ꮫ఍ ࣉࣟࢢ࣒ࣛጤဨ


⾜᪉࿴ᙪ

 ᖺࠥ ᮾ㑥኱Ꮫ⌮Ꮫ㒊 ᐈဨᩍᤵࠊᮾ㑥኱Ꮫ⌮Ꮫ㒊 ኱Ꮫ㝔ㅮ⩏㸦ே㛫⏕≀Ꮫ㸧ᢸᙜ  ㅮ⩏ࢸ࣮࣐ࠕ⑌ᝈࣔࢹ࣐ࣝ࢘ࢫ࡜⑓⌮ゎᯒ࣭⚄⤒㍈⣴ࡢ෌⏕ㄏᑟ࣭᭱᪂ࡢ⥳ෆ㞀◊✲ࠖ

－1－ࣉࣟࢪ࢙ࢡࢺྡ

⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 9 ௳㸧
1.

Tatsufumi Murakami, Yuri Ito, Kazunori Sango, Kazuhikoatabe, Yoshihide Sunada. Humantransthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model ofhereditary transthyretin amyloidosis. Neurochemistry International., 164, 105507-105507,
202303. (doi.org/10.1016/j.neuint.2023.105507)
2.

Yosuke Nagai, Keiichiro Matoba, Hideji Yako, Shinji Ohashi, Kensuke Sekiguchi, Etsuko
Mitsuyoshi, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura. Rhokinase inhibitor restores glomerular fatty acid metabolism in diabetic kidney disease. Biochemical
and Biophysical Research Communications., 649, 32-38, 20230131.
(doi.org/10.1016/j.bbrc.2023.01.088)

3.

Sho Osonoi, Hiroki Mizukami, Yuki Takeuchi, Hikari Sugawa, Saori Ogasawara, Shizuka Takaku,
Takanori Sasaki, Kazuhiro Kudoh, Koichi Ito, Kazunori Sango, Ryoji Nagai, Yasuhiko
Yamamoto, Makoto Daimon, Hiroshi Yamamoto, Soroku Yagihashi. RAGE activation in
macrophages and development of experimental diabetic polyneuropathy. JCI Insight., B 7, 23:20221208. (doi.org/10.1172/jci.insight.160555)

4.

Hanif Ali, Miyu Kobayashi, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji
Hayashi, Ryushi Kawakami, Koichiro Tsuchiya, Kazunori Sango, Tamotsu Tanaka. Peroxisomes
attenuate cytotoxicity of very long-chain fatty acids. Biochimica et Biophysica Acta (Molecularand cell biology of lipids)., 1868, 2: 159259-159259, 20221129.
(doi.org/10.1016/j.bbalip.2022.159259)

5.

Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Nozomi Sakata, Naoko Niimi, Koji
Fukui, Minoru Saitoe, Kazunori Sango. A Drosophila model of diabetic neuropathy reveals a
crucial role of proteasome activity in the glia. Cold Spring Harbor Laboratory., 20220923.
(doi.org/10.1101/2022.09.22.509008)

6.

Shizuka Takaku, Kazunori Sango. Pretreatment with onisamide Mitigates Oxaliplatin-Induced
Toxicity in Rat DRG Neurons and DRG Neuron Schwann Cell Co-Cultures. International
Journal of Molecular Sciences., 23, 17: 9983-9983, 20220901. (doi.org/10.3390/ijms23179983)

－1

－

7.

Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke
Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori
Utsunomiya, Rimei Nishimura. Rho-associated, coiled-coil-containing protein kinase 1 regulates
development of diabetic kidney disease via modulation of fatty acid metabolism. Kidney
International., 20220518. (doi.org/10.1016/j.kint.2022.04.021)

8.

Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo,
Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango,
Koichi Kato. Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell
Death via the AMPK-Dependent Signaling Pathway in Immortalized Fischer Rat Schwann Cells 1.
International Journal of Molecular Sciences., 23, 8: 4405-4405, 20220415.
(doi.org/10.3390/ijms23084405)

9.

Shiori Memezawa, Takanari Sato, Arisa Ochiai, Miku Fukawa, Sui Sawaguchi, Kazunori Sango,
Yuki Miyamoto, Junji Yamauchi. The Antiepileptic Valproic Acid Ameliorates Charcot-MarieTooth 2(CMT2 ) Disease-Associated HARS1 Mutation-Induced Inhibition of Neuronal Cell

Morphological Differentiation Through c-Jun N-terminal Kinase. Neurochemical Research.,20220405. (doi.org/10.1007/s11064-022-03587-z)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 4 ௳㸧

Kazunori Sango. Novel neuron Schwann cell co-culture models to study peripheral nerve
degeneration and regeneration. Neural Regeneration Research., 2022, December 21. (doi:10.4103/1673-5374.363195)

2.

Kazunori Sango, Shizuka Takaku, Masami Tsukamoto, Naoko Niimi, Hideji Yako. Glucagon-Like
Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating
Remedies. Frontiers in Cell and Developmental Biology., 10, 950623-950623, 2022.
(doi.org/10.3389/fcell.2022.950623)

 ୕஬୍᠇ຍ⸨ᏹ୍⢾ᒀ⑓ᛶᮎᲈ⚄⤒㞀ᐖࡢ᪂つ἞⒪ᶆⓗࡢ᥈⣴⢾ᒀ⑓ྜే⑕࣓
ࢹ࢕࢝ࣝࢪ࣮ࣕࢼࣝ♫ᮾி36, 262-265, 2022.
4. ୕஬୍᠇, ኱▮཭Ꮚ. ➨ 44 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵࣉ㛤ദሗ࿌Japan

Maillard Reaction Society News Letter., 21, 4-5, 2022.

－1 5－

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 3 ௳㸧
1.

୕஬୍᠇ ᰴ໬ Schwann ⣽⬊ࢆ⏝࠸ࡓ㍈⣴෌⏕ࡸࢽ࣮ࣗࣟࣃࢳ࣮◊✲ࡢ᪂ࡓ࡞ᒎ㛤➨34 ᅇ᪥ᮏ⚄⤒ච␿Ꮫ఍Ꮫ⾡㞟఍ 2022/10/20㹼2022/10/21 ฟᓥ࣓ࢵࢭ㛗ᓮ/㛗ᓮ┴㛗ᓮᕷ
2. ୕஬୍᠇ ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊ࡢᇵ㣴⣔ࢆ⏝࠸ࡓᮎᲈ⚄⤒⑓ኚ࡬ࡢ࢔ࣉ࣮ࣟࢳ
UBE ᰴᘧ఍♫ࢭ࣑ࢼ࣮ 2022/6/3㹼2022/6/4 UBE ᰴᘧ఍♫ᒣཱྀ┴Ᏹ㒊ᕷ
3. 㕥ᮌ࣐ࣜ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⚄⤒⑌ᝈ◊✲㹼⚄⤒ኚᛶ⑌ᝈ࠿ࡽ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖ࡬㹼➨ 65 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ࢩ࣏ࣥࢪ࣒࢘ࠕ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖ㹼ᇶ♏࡜⮫

ᗋࡢ⼥ྜࢆ┠ᣦࡋ࡚㹼ࠖ 2022/5/12㹼5/14 ⚄ᡞᅜ㝿఍㆟ሙරᗜ┴⚄ᡞᕷࡑࡢ௚ 㸦ィ 15 ௳㸧⮬⏤ᥖ㍕
1.

Kazunori Sango, Shizuka Takaku, Hideji Yako, Masami Tsukamoto, Naoko Niimi Exendin-4
enhances DRG neurite outgrowth, Schwann cell survival/migration and myelination via activating
PI3K-AKT signaling pathway ᪥ᮏ⏕⌮Ꮫ఍➨ 100 ᅇグᛕ኱఍

2023/3/14㹼3/16 ᅜ❧ி㒔ᅜ㝿఍㤋/ி㒔ᗓி㒔ᕷ
2.

ඵᏊⱥྖࠊ୕஬୍᠇

㧗࢞ࣛࢡࢺ࣮ࢫ㈇Ⲵ࡛ㄏᑟࡉࢀࡿࢩࣗ࣡ࣥ⣽⬊ᰴ㞀ᐖ࡜ aldose

reductase 㜼ᐖ⸆ࡢ᳨ウ ➨ 7 ᅇ᪥ᮏ࣑࢚ࣜࣥ◊✲఍

2023/2/11 ᶓ὾ࣛࣥࢻ࣐࣮ࢡ/⚄ዉᕝ┴ᶓ὾ᕷ
3.

㧗ஂ㟼㤶ࠊ୕஬୍᠇ ᰴ໬ឤぬࢽ࣮ࣗࣟࣥ ND7/23 ࡜ᰴ໬ࢩࣗ࣡ࣥ⣽⬊ IFRS1 ࡢ࣑࢚ࣜࣥᙧᡂඹᇵ㣴⣔⣔ࡢ☜❧ ➨ 7 ᅇ᪥ᮏ࣑࢚ࣜࣥ◊✲఍

2023/2/11 ᶓ὾ࣛࣥࢻ࣐࣮ࢡ/⚄ዉᕝ┴ᶓ὾ᕷ
4.

᪂ぢ┤Ꮚࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫୗ࡛ࡢ⾑⟶ෆ⓶⣽⬊ࡢ⢾௦ㅰ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2022/11/30㹼12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴༓ⴥᕷ5.

㧗ஂ㟼㤶ࠊ୕஬୍᠇ ᮎᲈ⚄⤒⑓ኚ࡟ᑐࡍࡿࢰࢽࢧ࣑ࢻࡸ࢚ࢡࢭࢼࢳࢻࡢ᭷⏝ᛶ ➨ ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ࢩ࣏ࣥࢪ࣒࢘ࠕ㍈⣴ᦆയ࡜ࢽ࣮ࣗࣟࣃࢳ࣮ࡢ⑓ែ⏕໬Ꮫࠖ2022/11/9
㹼11/11 ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ

6.

୕஬୍᠇ࠊඵᏊⱥྖ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿࢩࣗ࣡ࣥ⣽⬊Ṛࡣ Poly(ADP-ribose) polymerase 㜼ᐖ࡟ࡼࡾᢚไࡉࢀࡿ ➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ኱఍
2022/11/9㹼11/11 ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ7.

୕஬୍᠇ ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖ◊✲ࡢࢺࣆࢵࢡࢫ ➨ 37 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ࢩ࣏ࣥࢪ
࣒࢘ࠕ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ◊✲࣭デ⒪᭱᪂▱ぢࠖ 2022/10/21㹼10/22 ᅜ❧ி㒔ᅜ㝿఍㤋/ி㒔ᗓி㒔ᕷ

－1 6－

8.

ඵᏊⱥྖࠊ᪂ぢ┤Ꮚࠊ㧗ஂ㟼㤶ࠊ୕஬୍᠇

࢞ࣛࢡࢺ࣮ࢫ㈇Ⲵ࡟ࡼࡿ IMS32 ࢩࣗ࣡ࣥ⣽➨ 37 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍

⬊㞀ᐖ࡜࣏࣮ࣜ࢜ࣝ௦ㅰ⤒㊰ࡢゎᯒ

2022/10/21㹼

10/22 ᅜ❧ி㒔ᅜ㝿఍㤋/ி㒔ᗓி㒔ᕷ
9.

୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭ࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡛ㄏᑟࡉࢀࡿࢩࣗ࣡ࣥ⣽⬊Ṛࡢᶵᗎゎᯒ
➨ 33 ᅇ᪥ᮏᮎᲈ⚄⤒Ꮫ఍Ꮫ⾡㞟఍㒔2022/9/9㹼9/10 ៞᠕⩏ሿ኱Ꮫ୕⏣࢟ࣕࣥࣃࢫ/ᮾி༊

10. ୕஬୍᠇ࠊ➉⃝♸㈗ࠊ㧗ஂ㟼㤶 ᰴ໬ឤぬࢽ࣮ࣗࣟࣥ ND7/23 ࡜ᰴ໬ࢩࣗ࣡ࣥ⣽⬊ IFRS1ࡢ㧊㠧ᙧᡂඹᇵ㣴⣔ࡢ☜❧➨ 31 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍

2022/8/27㹼8/28 ᒱ㜧኱Ꮫᰗᡞ࢟ࣕࣥࣃࢫ/ᒱ㜧┴ᒱ㜧ᕷ
11. Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Naoko Niimi, Minoru Saitoe, Kazunori Sango
Role of glial proteasome activity in a Drosophila model of diabetic peripheral neuropathy ➨ 45ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ (Neuro2022)

2022/6/30㹼7/3 Web 㛤ദ㸤Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥ

ࢱ࣮Ἀ⦖┴ᐅ㔝‴ᕷ
12. Kazunori Sango Immortalized adult rodent Schwann cells as useful tools to study peripheral
nerve degeneration and regeneration. European Society of Medicine (ESMED) General
Assembly 2022 2022/8/4㹼8/6 On line
13. Kazunori Sango, Hideji Yako. Involvement of Poly (ADP-ribose) polymerase in Schwann cell
death under high-glucose pyruvate-depleted conditions. 2022 Peripheral Nerve Society Annual
Meeting, 2021/5/14㹼5/17 On line

Miami/USA

14. ୕஬୍᠇ࠊ㧗ஂ㟼㤶 Zonisamide alleviates oxaliplatin-induced DRG neuron death invitro ➨ 63 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2022/5/18㹼5/21 Web 㛤ദ㸤ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ/ᮾி㒔༓௦⏣༊15. ඵᏊⱥྖࠊຍ⸨ᩥᏊࠊ᪂ぢ┤Ꮚࠊ㧗ஂ㟼㤶ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉ
ᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿ⣽⬊Ṛ࡜ゎ⢾⣔-TCA ᅇ㊰ࣇࣛࢵࢡࢫࡢไᚚ࡟࠾ࡅࡿ
PARP ࡢᙺ๭ࡢゎ᫂ ➨ 65 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ 2022/5/12㹼5/14 ⚄ᡞᅜ㝿఍㆟ሙරᗜ┴⚄ᡞᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧 ୕஬୍᠇ ࢫࢺࢵࣉ࣭ࢨ࣭⢾ᒀ⑓ྜే⑕ ඲Ꮫయ㦂ࢮ࣑ࢼ࣮ࣝ 2022/12/18 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤᮾி㒔ୡ⏣㇂༊

－1 7－

IV. ≉グ஦㡯࠙ㅮ⩏➼ࠚ
1. ୕஬୍᠇ ⢾ᒀ⑓࡜௦ㅰ ᶓ὾ᕷ❧኱Ꮫ་Ꮫ㒊ㅮ⩏ࠕ⑓ែ௦ㅰ⏕⌮Ꮫࠖ 2022/4/22 ᶓ὾ᕷ❧኱Ꮫ་Ꮫ㒊/⚄ዉᕝ┴ᶓ὾ᕷ࠙ࡑࡢ௚ࠚ
1. ୕஬୍᠇ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍බເ࣮࣡ࢡࢩࣙࢵࣉ࣮࢜࢞ࢼ࢖ࢨ࣮ࠕ⢾໬ࢫࢺࣞࢫ࡜⚄⤒⣔⑌ᝈ◊✲ࡢ᭱๓⥺ࠖ2022/11/30 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴༓ⴥᕷ
2. ୕஬୍᠇ ➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍බເࢩ࣏ࣥࢪ࣒࣮࢘࢜࢞ࢼ࢖ࢨ࣮ࠕ㍈⣴ᦆയ࡜ࢽࣗ
࣮ࣟࣃࢳ࣮ࡢ⑓ែ⏕໬Ꮫࠖ2022/11/11 ྡྂᒇᅜ㝿఍㆟ሙ/ឡ▱┴ྡྂᒇᕷ
3. Kazunori Sango Guest Editor, International Journal of Molecular Sciences, Associate Editor (Boardof Clinical Diabetes), Frontiers in Endocrinology
4. ୕஬୍᠇  Ⱚᾆᕤᴗ኱Ꮫ㐃ᦠ኱Ꮫ㝔ᐈဨᩍᤵࠊᶓ὾ᕷ❧኱Ꮫᐈဨᩍᤵ࣭་Ꮫ㒊㠀ᖖ໅ㅮᖌࠊឡ▱Ꮫ㝔኱Ꮫ⸆Ꮫ㒊⸆๣἞⒪Ꮫㅮᗙᐈဨ◊✲ဨࠊ᪥ᮏᮎᲈ⚄⤒Ꮫ఍⌮஦࣭⦅㞟ጤဨ㛗࣭࠶ࡾ᪉ጤဨ࣭㈈ົጤဨࠊ᪥ᮏ⑓ែ⏕⌮Ꮫ఍⌮஦࣭┘஦ࠊ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ᙺဨࠊ᪥
ᮏ࣑࢚ࣜࣥ◊✲఍ୡヰேࠊ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍ᖿ஦ࠊ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ホ㆟ဨࠊ᪥ᮏ⏕⌮Ꮫ఍ホ㆟ဨ

－1－ࣉࣟࢪ࢙ࢡࢺྡ

෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧1.

equal contribution, co-corresponding author

Nakajima I, Tsukimura T, Ono T, Shiga T, Shitara H, Togawa T, Sakuraba H, Miyaoka Y. In Vivo
Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent
Stem Cells. Cell Transplantation 32:9636897231173734. 2023㸦ᰝㄞ᭷㸧

2.

de Majo M, Koontz M, Marsan E, Salinas N, Ramsey A, Kuo YM, Seo K, Li H, Dr ger N, Leng
K, Gonzales SL, Kurnellas M, Miyaoka Y, Klim JR, Kampmann M, ard ME, Huang EJ, Ullian
EM. Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43
pathology. Stem Cell Reports 18:706-719. 2023㸦ᰝㄞ᭷㸧

3.

Takahashi G, Kondo D, Maeda M, Morishita Y, Miyaoka Y. Genome editing is induced in abinary manner in single human cells. iScience 25:105619. 2022㸦ᰝㄞ᭷㸧

4.

Song D , Takahashi G , heng Y , Matsuo-Takasaki M, Li J, Takami M, An Y, Hemmi Y,
Miharada N, Fujioka T, Noguchi M, Nakajima T, Saito MK, Nakamura Y, Oda T, Miyaoka Y ,Hayashi Y . Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in ilson sdisease-specific hepatocytes. Human Molecular Genetics 31:3652-3671. 2022㸦ᰝㄞ᭷㸧

5.

Takahashi R, Takahashi G, Kameyama Y, Sato M, Ohtsuka M and ada K. Gender-Difference inHair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional
FGF5 Mutations. International Journal of Molecular Sciences 23:11855. 2022㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

ᐑᒸ భ୍㑻 ௚ⴭ⪅40ྡྥ࡜Ᏻ඲ᛶ࿘▱2023ᖺ

ࢤࣀ࣒⦅㞟ᢏ⾡᝟ሗᶵᵓ㸦ィ 1 ௳㸧㹼ᐇ㦂ୖࡢ࣏࢖ࣥࢺ㸭⏘ᴗ฼⏝࡟ྥࡅࡓ◊✲㛤Ⓨື

ISBN

978-4-86502-242-1

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕－1－

࠙Ⓨ⾲Ꮫ఍ࠚ
1.

Cold Spring Harbor Laboratory Meeting, Genome Engineering

2.

➨45ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍

3. ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍➨7ᅇ኱఍

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧࣭ ᐑᒸభ୍㑻㸸2022.11.24,

ࠕ⏕࿨⛉Ꮫ◊✲⪅ࡢᐇែࠖ࡜㢟ࡋ࡚ࠊୡ⏣㇂༊❧ඵᖭᒣᑠᏛ

ᰯඣ❺࡟࢟ࣕࣜ࢔ᩍ⫱ㅮ₇－ 11 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࡀࢇච␿ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Masayuki Kuraoka, Nicholas C Curtis, Akiko Watanabe, Hidetaka Tanno, Seungmin
Shin, Kevin Ye, Elizabeth Macdonald, Olivia Lavidor, Susan Kong, Tarra Von Holle,
Ian Windsor, Gregory C Ippolito, George Georgiou, Emmanuel B Walter, Garnett
Kelsoe, Stephen C Harrison, M Anthony Moody, Goran Bajic, Jiwon Lee. Infant
Antibody Repertoires during the First Two Years of Influenza Vaccination. mBio.,e0254622, 20221031. (doi.org/10.1128/mbio.02546-22)

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

୹㔝⚽ᓫ㸦ᣍᚅㅮ₇㸧72%,5$➨ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ  ࠾ⲔࡢỈࢯࣛࢩࢸ࢕
࢝ࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮

2.

୹㔝⚽ᓫ㸦ᣍᚅㅮ₇㸧ᮾிᕤᴗ኱Ꮫ࣭⣽⬊ไᚚᕤᏛ◊✲ࢭࣥࢱ࣮ ࡑࡢ௚ 㸦ィ 2 ௳㸧⮬⏤ᥖ㍕
1.

୹㔝⚽ᓫ
࣮࣍ࣝ

࣏ࢫࢱ࣮Ⓨ⾲  ➨ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍  ⇃ᮏᇛ

2.

୹㔝⚽ᓫ
఍㤋

࣏ࢫࢱ࣮Ⓨ⾲  ⣽⬊ࢆ๰ࡿ◊✲఍  ᮾᕤ኱ⶶ๓

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

－ 111 －

ࣉࣟࢪ࢙ࢡࢺྡ

యෆ᫬ィࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Yasuko O. Abe, Hikari Yoshitane * Co-correspondence , Dae ook Kim, Michinori Koebis,
Kazuki Nakao, Atsu Aiba, Jae Kyoung Kim and Yoshitaka Fukada Rhythmic transcription of
Bmal1 stabilizes the circadian timekeeping system in mammals. Nature Communications (IF:14.92), 13 (1): 4652 (2022)

2.

Hitomi Yamamoto-Matsuda, Keita Miyoshi, Mai Moritoh, Hikari Yoshitane, Yoshitaka Fukada,
Kuniaki Saito, Soichiro Yamanaka, Mikiko C SiomiLint-O cooperates with L(3)mbt in target genesuppression to maintain homeostasis in fly ovary and brain. EMBO Rep. (IF: 8.81), 23 (10):e53813 (2022)

3.

Taira ada, Yukiko Yamamoto, Yukiko Takasugi, Hirotake Ishii, Taketo Uchiyama, Kaori Saitoh,
Masahiro Suzuki, Makoto Uchiyama, Hikari Yoshitane, Yoshitaka Fukada, Shigeki Shimba
Adiponectin regulates the circadian rhythm of glucose and lipid metabolism. J. Endocrinol. (IF:4.29), 254 (2):121-133 (2022)

4.

Shingo Hiroki, Hikari Yoshitane, Hinako Mitsui, Hirofumi Sato, Chie Umatani, Shinji Kanda,
Yoshitaka Fukada, Yuichi Iino. Molecular encoding and synaptic decoding of context during salt
chemotaxis in C. elegans. Nature Communications (IF: 14.92), 13 (1): 2928 (2022)

5.

Satoshi Kawakami, Hikari Yoshitane (* Co-correspondence), Taiki Morimura, ataru Kimura,and Yoshitaka Fukada Diurnal shift of mouse activity by the deficiency of an aging-related gene
Lmna. Journal of Biochemistry (IF: 3.39), 171 (5): 509-518 (2022)

6.

Hikari Yoshitane (* Co-correspondence), Kiyomichi Imamura, Takenori Okubo, Yuta Otobe,
Satoshi Kawakami, Shunsuke Ito, Toru Takumi, Kazuki Hattori, Isao Naguro, Hidenori Ichijo, andYoshitaka Fukada mTOR-AKT signaling in cellular clock resetting triggered by osmotic stressAntioxidants & Redox Signaling I. , 37 (10-12): 631-646 (2022)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼－ 11 －

㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 10 ௳㸧
1.

Hikari Yoshitane, Post-translational regulation of the mammalian clock protein complexࠊ࢔ࢪ࢔᫬㛫⏕≀Ꮫ఍ ASRS 2023ࠊ2023/3/31ࠊࢺࣝࢥ ࢖ࢫࢱࣥࣈ࣮ࣝࠊᣍᚅㅮ₇2.

ྜྷ✀ගࠊ᫬ィ⪁໬: ຍ㱋࡟ᇶ࡙ࡃ⪁໬⌧㇟ࡢศᏊ࣓࢝ࢽࢬ࣒ࠊ᪥ᮏ⏕⌮Ꮫ఍ ➨ 100 ᅇ グᛕ኱఍ࢩ࣏ࣥࢪ࣒࢘ 2S07eࠕᴫ᪥ࣜࢬ࣒ࡀᇶ㍈࡜࡞ࡿ⏕࿨ࡢᜏᖖᛶ࣭ᣢ⥆ᛶ㸸యෆ᫬ィࡢ஘ࢀࡀᣍࡃ೺
ᗣၥ㢟ࡢඞ᭹࡟ྥࡅ࡚ࠖࠊ2023/3/15ࠊி㒔ᗓ㸦ி㒔ᅜ㝿఍㆟ሙ㸧ࠊᣍᚅㅮ₇3.

ྜྷ✀ගࠊᴫ᪥᫬ィࢡ࣮࢜ࢶ㸸┿᰾⏕≀࡛ࡶࢱࣥࣃࢡ㉁᣺ືᏊࡀ⮬ᚊ᣺ືࡍࡿྍ⬟ᛶࠊ➨ 29 ᅇ ᪥ᮏ᫬㛫⏕≀Ꮫ఍Ꮫ⾡኱఍ࠊ2022/12/4ࠊᰣᮌ┴㸦Ᏹ㒔ᐑ኱Ꮫ㸧ࠊᣍᚅㅮ₇4.

ྜྷ✀ගࠊ᫬㛫ࢱࣥࣃࢡ㉁Ꮫ㸸᫬ィࢱࣥࣃࢡ㉁ࡢ┦஫స⏝ࣜࢬ࣒࡜⩻ヂᚋಟ㣭ࢥ࣮ࢻࠊ➨ 95 ᅇ ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࣒࢘ 1S03e ᫬㛫ࢱࣥࣃࢡ㉁Ꮫࠥ᫬ࢆ⏕ࡳฟࡍࢱࣥࣃࢡ㉁≉ᛶࠥࠊ
2022/11/9ࠊឡ▱┴㸦ྡྂᒇᅜ㝿఍㆟ሙ ᅜ㝿఍㆟ሙ㸧ࠊᣍᚅㅮ₇5.

ྜྷ✀ගࠊࠕ᫬ࠖࢆ⏕ࡳฟࡍศᏊ࣓࢝ࢽࢬ࣒ࠊ༓ⴥ኱Ꮫ 2022 ᖺᗘ ⏕໬Ꮫ≉ㄽ ➨ 18 ᅇ⏕໬ࢭ࣑ࢼ
࣮ࠊ2022/10/27ࠊ༓ⴥ┴㸦༓ⴥ኱Ꮫ ⸆Ꮫ㒊ㅮ⩏ᐊ 13 ␒ᩍᐊ㸧ࠊᣍᚅㅮ₇

6.

Hikari Yoshitane, Circadian quartz: Implication for protein oscillator in mammalian circadianclockworkࠊSapporo Symposium on Biological Rhythmࠊ2022/8/14ࠊ໭ᾏ㐨㸦໭ᾏ㐨኱Ꮫ
International Conference ࣮࣍ࣝ㸧ࠊᣍᚅㅮ₇

7.

Hikari Yoshitane, Yasuko O. Abe, Dae W. Kim, Jae K. Kim and Yoshitaka Fukada, Rhythmictranscription of Bmal1 stabilizes the circadian timekeeping system in mammalsࠊ࣮ࣚࣟࢵࣃ
᫬㛫⏕≀Ꮫ఍ EBRS 2022ࠊ2022/7/26ࠊࢫ࢖ࢫ ࢳ࣮ࣗࣜࢵࣄࠊᣍᚅㅮ₇8.

ྜྷ✀ගࠊࠕ᫬ࠖࢆࣅࢵࢡࢹ࣮ࢱ࡜ࢩࢫࢸ࣒ࣂ࢖࢜ࣟࢪ࣮࡛⌮ゎࡍࡿࠊᮾி኱Ꮫ ⏕≀⛉Ꮫࢭ࣑ࢼ
࣮ࠊ2022/7/4ࠊᮾி㒔㸦ᮾி኱Ꮫ ⌮Ꮫ㒊 3 ྕ㤋㸧ࠊᣍᚅㅮ₇

9.

Hikari YoshitaneࠊMolecular mechanism of circadian clockworkࠊThe University of Tokyo,
Advanced photon life sciencesࠊ2022/4/26ࠊ࢜ࣥࣛ࢖ࣥࠊᣍᚅㅮ₇10.

ྜྷ✀ගࠊࠕ᫬ࠖࢆ⏕ࡳฟࡍศᏊ࣓࢝ࢽࢬ࣒ࠊᮾி㒔❧኱Ꮫ 2022 ᖺᗘ ⏕࿨⛉Ꮫᩍᐊࢭ࣑ࢼ࣮ࠊ
2022/4/22ࠊᮾி㒔㸦ᮾி㒔❧኱Ꮫ 12 ྕ㤋 202 ᐊ㸧ࠊᣍᚅㅮ₇ࡑࡢ௚ 㸦ィ ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

－ 11 －

IV. ≉グ஦㡯－ 11 －

ࣉࣟࢪ࢙ࢡࢺྡ

I.

⣽⬊⭷◊✲ᐊ

ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y,
Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi
N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y,
Murakami M.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8

Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups   Cell Rep 42(2):111940, 2023 doi: 10.1016/j.celrep.2022.111940.
2.

Komatsuya K, Iguchi T, Fukuyama M, Kawashima I, Ogura K, Kikuchi N, Shimoda Y, Takeda Y,
Shimonaka M, Yamamoto N, Sugiura N, Maeda N, Kasahara K. Phosphacan acts as a repulsive
cue in murine and rat cerebellar granule cells in a TAG-1/GD3 raft-dependent manner     
J Neurochem 163(5): 375-390, 2022 doi:10.1111/jnc.15709 㸦⾲⣬࡟᥇⏝ࡉࢀࡓ㸧

3.

Komatsuya K, Sakura T, Shiomi K, Omura S, Hikosaka K, Nozaki T, Kita K, and Inaoka D-K.
Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and
Complex III Pharmaceuticals (Basel) 15(7): 903, 2022

4.

Liang L, Takamiya R, Miki Y, Heike K, Taketomi Y, Sugimoto N, Yamaguchi M, Shitara H,
Nishito Y, Kobayashi T, Hirabayashi T, Murakami M. Group IVE cytosolic phospholipase A2
limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine
FASEB J. 36(5):e22301, 2022.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 4 ௳㸧

Komatsuya K, Kikuchi N, Hirabayashi T, Kasahara K. Gangliosies and Ganglioside GD3-Binding
Proteins Encyclopedia 42718, 2023. https://encyclopedia.pub/entry/42718

2.

Komatsuya K, Kikuchi N, Hirabayashi T, Kasahara K. : The Regulatory Roles of Cerebellar
Glycosphingolipid Microdomains/Lipid Rafts Int J Mol Sci 24(6):5566, 2023. doi:
10.3390/ijms24065566.

3.

Harada S, Taketomi Y, Aiba T, Kawaguchi M, Hirabayashi T, Uranbileg B, Kurano M, Yatomi Y,
Murakami M. The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine－ 115 －

Metabolism. Biomolecules 13:47, 2023 doi: 10.3390/biom13030471.
4.

ᖹᯘ ဴஓ ࢔ࢩࣝࢭ࣑ࣛࢻ௦ㅰ࡜⓶⭵ࣂࣜ࢔ᙧᡂ ࢔ࣞࣝࢠ࣮ࡢ⮫ᗋ 42(2) 143-147
2022 ᖺ 2 ᭶

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

ᑠᯇ㇂ၨ௓ࠊ⳥ụ⣖ோࠊᑠ಴₩ࠊᕝᓥ⫱ኵࠊ㓇஭⚈ኴࠊ῝⃝ᚁ⩏ࠊⰼ⏣㈼ኴ㑻ࠊ㛗⏣┤ᶞࠊ✀Ꮚᓥᖾ♸ࠊཎᏕᙪࠊ➟ཎᾈ஧ SARS-CoV-2 ࡢ⬡㉁ࣛࣇࢺࢆ௓ࡋࡓ⣽⬊౵ධᶵᵓࡢゎ᫂
➨ 15 ᅇࢭ࣑ࣛࢻ◊✲఍Ꮫ⾡㞟఍ 2022 ᖺ 10 ᭶ 19-21 ᪥ ᮐᖠ

2.

ᑠᯇ㇂ၨ௓ࠊ⳥ụ⣖ோࠊᑠ಴₩ࠊᕝᓥ⫱ኵࠊⰼ⏣㈼ኴ㑻ࠊ㛗⏣┤ᶞࠊ✀Ꮚᓥᖾ♸ࠊཎᏕᙪࠊ➟ཎᾈ஧

SARS-CoV-2 ࡢ⬡㉁ࣛࣇࢺࢆ௓ࡋࡓ⣽⬊ෆྲྀࡾ㎸ࡳ

➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍

2022 ᖺ 11 ᭶ 9-11 ᪥ ྡྂᒇ3.

4.

ᕝཱྀ⯙ࠊ➟ཎᾈ஧ࠊᮧୖㄔࠊᖹᯘဴஓ

PNPLA6 ࠾ࡼࡧ PNPLA7 ࡣ୰ᯡ⚄⤒⣔࡟࠾࠸࡚ࢽ

࣮ࣗࣟࣥࡢ⥔ᣢ࡜ᜏᖖᛶ࡟ᚲせ࡛࠶ࡿ

Neuro2022

2022 ᖺ 6 ᭶ 30 ᪥-7 ᭶ 3 ᪥ Ἀ⦖

Kawaguchi M, Kasahara K, Hirabayashi T, Murakami M. The lysophospholipases PNPLA6 and
PNPLA7 are required for neuronal homeostasis in the CNS. 17th International Conference on
Bioactive Lipids in Cancer, Inflammation, and Related Diseases 2022.10.30-11.2 New Orleans,Louisiana, USA

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 3 ௳㸧
1.

ᖹᯘဴஓ ࢔ࢩࣝࢭ࣑ࣛࢻ௦ㅰ␗ᖖ࡟ࡼࡿ㨶㫣Ⓞ⑓ែࡢゎᯒᡤෆ◊✲Ⓨ⾲఍㸦➨ 1 㒊఍㸧

2.

➟ཎᾈ஧ ⣽⬊⭷࡟࠾ࡅࡿ⢾⬡㉁ࡢᶵ⬟ゎᯒ ᡤෆ◊✲Ⓨ⾲఍㸦➨ 2 㒊఍㸧

3.

ᕝཱྀ⯙

୰ᯡ⚄⤒⣔ࡢࣜࢰ࣍ࢫ࣍ࣜࣃ࣮ࢮḞᦆ࡟ࡼࡿ⚄⤒ኚᛶ࡜➽ⴎ⦰ᡤෆ◊✲Ⓨ⾲

఍㸦➨ 3 㒊఍㸧

IV. ≉グ஦㡯1.

ᑠᯇ㇂ၨ௓㸸➨ 15 ᅇࢭ࣑ࣛࢻ◊✲఍Ꮫ⾡㞟఍ 2022 ᖺᗘ Young Investigator Award ཷ㈹2.

ᕝཱྀ⯙㸸ᡤෆ◊✲Ⓨ⾲఍㸦➨ 3 㒊఍㸧ඃ⚽Ⓨ⾲⪅－ 116 －

3.

➟ཎᾈ஧㸸බ┈㈈ᅋἲே Ỉ㇂⢾㉁⛉Ꮫ᣺⯆㈈ᅋ㑅⪃ጤဨ

4.

ᖹ ᯘ ဴ ஓ ࠊᮧ ୖ ㄔ 㸸 3&7 ฟ 㢪 ࠕ ⚄⤒ ኚ ᛶ ཬࡧ➽ ⴎ ⦰ ࣔ ࢹࣝ ື ≀ ࠖᅜ㝿 ฟ 㢪 ␒ ྕ 㸸
PCT/JP2022/038495 ᅜ㝿ฟ㢪᪥㸸2022.10.11－ 117 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࣇࣟࣥࢸ࢕࢔◊✲ᐊ㸦⬻௦ㅰไᚚࢢ࣮ࣝࣉ㸧I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1

Sayaka Hirai, Hideki Miwa, Hiroko Shimbo, Keisuke Nakajima, Masahiro Kondo, Tomoko
Tanaka, Chiaki Ohtaka-Maruyama, Shinobu Hirai, Haruo Okado. The mouse model of intellectual
disability by BTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic
impairment. Molecular psychiatry

2

Akiyo Natsubori, Shinobu Hirai, Soojin Kwon, Daisuke Ono, Fei Deng, Jinxia

an, Momoka

Miyazawa, Takashi Kojima, Haruo Okado, Akihiro Karashima, Yulong Li, Kenji F Tanaka,
Makoto Honda. Serotonergic neurons control cortical neuronal intracellular energy dynamics bymodulating astrocyte-neuron lactate shuttle. iScience 26(1) 105830-105830
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼1.

㸦ィ 2 ௳㸧᪥ᮏ⚄⤒⛉ᏛᏛ఍ Ꮫ఍ㄅෆ ⚄⤒⛉Ꮫࢽ࣮ࣗࢫ࡬ࡢᐤ✏͆⢭⚄⑌ᝈࡢ᪂ࡓ࡞⎔ቃせᅉࢆᥦၐࠊ⾲⌧ᆺࢆⓎぢ͇ᖹ஭ᚿఙ 1R0D\&RQVHFXWLYH1XPEHU

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2022 ᖺ 3 ᭶ 21 ᪥

➨ 16 ᅇ

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2022 ᖺ 6 ᭶ 9 - 13 ᪥ 33rd CINP Hybrid
࣮Ⓨ⾲

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orld Congress of Neuropsychopharmacology ࣏ࢫࢱHigh-sucrose diets contribute to brain angiopathy with impaired glucose uptake into thebrain parenchyma and psychosis-related higher brain dysfunctions in mice
Miwa, Yasuto Kunii, Makoto Arai, Haruo Okado

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 2 ௳㸧2022 ᖺᗘ∧ 㒔་Ꮫ◊ࣃࣥࣇࣞࢵࢺ࡬ࡢ◊✲⤂௓ࡢᐤ✏ ᖹ஭ᚿఙ2022 ᖺ 4 ᭶ྕ 㒔་Ꮫ◊ NE S ࡬ࡢᐤ✏ ᖹ஭ᚿఙIV. ≉グ஦㡯ཷ㈹➨ 16 ᅇ ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ ୍⯡₇㢟㈹ ዡບ㈹ᖹ஭ᚿఙ➨ 15 ᅇࠕ㈨⏕ᇽ ዪᛶ◊✲⪅ࢧ࢖࢚ࣥࢫࢢࣛࣥࢺࠖᖹ஭ᚿఙ
JSNP Excellent Presentation Award for CINP 2022 ᖹ஭ᚿఙ－ 11 －

Shinobu Hirai, Hidekiࣉࣟࢪ࢙ࢡࢺྡ

ࢤࣀ࣒་Ꮫ◊✲ࢭࣥࢱ࣮I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 16 ௳㸧
1.

Koichiro Kanamori, Kentaro Suina, Takehito Shukuya, Fumiyuki Takahashi, Takuo Hayashi,
Kieko Hara, Tsuyoshi Saito, Yoichiro Mitsuishi, Shoko Sonobe Shimamura,ira

inardi, Ken

Tajima, Ryo Ko, Tomoyasu Mimori, Tetsuhiko Asao, Masayoshi Itoh, Hideya Kawaji, Yoshiyuki
Suehara, Kazuya Takamochi, Kenji Suzuki, Kazuhisa Takahashi. CALML5 is a novel diagnostic
marker for differentiating thymic squamous cell carcinoma from type B3 thymoma. Thoracic
cancer., 20230316(doi.org/10.1111/1759-7714.14853)
2.

David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori
Tomoyasu. Transcriptomic exploration of the Coleopteran wings reveals insight into the evolutionof novel structures associated with the beetle elytron. Journal of Experimental Zoology. Part B,
Molecular and developmental evolution. 340,2: 197-213, 202303 (doi.org/10.1002/jez.b.23188)

3.

Ryo Negishi, Hitomi Yamakawa, Takeru Kobayashi, Mayuko Horikawa, Tatsu Shimoyama,
Fumiaki Koizumi, Takeshi Sawada, Keisuke Oboki, Yasushi Omuro, Chikako Funasaka, Akihiko
Kageyama, Yusuke Kanemasa, Tsuyoshi Tanaka, Tadashi Matsunaga, Tomoko Yoshino.
Transcriptomic profiling of single circulating tumor cells provides insight into human metastatic
gastric cancer. Communications Biology., 5,1㸸202212 (doi.org/10.1038/s42003-021-02937-x)

4.

Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa, Fumiya Yoshifuji, Toyoaki Natsume,
Atsushi Higashitani, Tomoo Ogi, Antony M. Carr, Masato T. Kanemaki, Yasukazu Daigaku.
Global landscape of replicative DNA polymerase usage in the human genome. Nature
Communications., 20221124. (doi.org/10.1038/s41467-022-34929-8)

5.

Masaru Koido, Chung-Chau Hon, Satoshi Koyama, Hideya Kawaji, Yasuhiro Murakawa,Kazuyoshi Ishigaki, Kaoru Ito, Jun Sese, Nicholas F. Parrish, Yoichiro Kamatani, Piero Carninci,
Chikashi Terao. Prediction of the cell-type-specific transcription of non-coding RNAs fromgenome sequences via machine learning. Nature Biomedical Engineering., 20221121.
(doi.org/10.1038/s41551-022-00961-8

6.

Laura J Grange, John J Reynolds, Farid Ullah, Bertrand Isidor, Robert F Shearer, enia Latypova,
Ryan M Baxley, Antony

Oliver, Anil Ganesh, Sophie L Cooke, Satpal S Jhujh, Gavin S

McNee, Robert Hollingworth, Martin R Higgs, Toyoaki Natsume, Tahir Khan, Gabriel－1－

Martos-Moreno, Sharon Chupp, Christopher G Mathew, David Parry, Michael A Simpson, Nahid
Nahavandi, afer Y ksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad
Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla

Brigatti, Alexander P A Stegmann, Masato

Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, ineb
Ammous, Jes s Argente, Naomichi Matsumoto, Constance T R M Stumpel, Alexander M R
Taylor, Andrew P Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E
Davis, Grant S Stewart. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes
and mosaic variegated hyperploidy. (doi.org/10.1038/s41467-022-34349-8) Nature
Communications., 13,1:
7.

6664-6664, 20221104. (doi.org/10.1038/s41467-022-34349-8)

Sundaramoorthy Revathidevi, Kazuyoshi Hosomichi, Toyoaki Natsume, Hirofumi Nakaoka,
Naoko T. Fujito, Hisako Akatsuka, Takehito Sato, Arasambattu Kannan Munirajan, Ituro Inoue.
AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits
Hyperproliferative Potential in hTERT-RPE1 Cells. International Journal of Molecular
Sciences., 23,19: 11124-11124,20220922. (doi.org/10.3390/ijms231911124)

8.

Junichi Mukae, Daichi Sadato, Takashi Toya, Satoru

atanabe, Chizuko Hirama, Ryosuke

Konuma, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Motohiro Kato, Kentaro Ohki,
Keisuke Oboki, Hironori Harada, Kazuteru Ohashi, Takao Deguchi, Yuka Harada, Noriko Doki.
Labile CD22 and CD19 expression in a case of Philadelphia chromosome-like acute lymphoblastic
leukemia. Leukemia & lymphoma., 1,4: 20220914. (doi.org/10.1080/10428194.2022.2116936)
9.

㓇஭ ▱ྐ, ΎỈ ၨ᫂, ㈆௵ ኱ᆅ, ᖹ㛫 ༓ὠᏊ, ⚄ཎ ᗣᘯ, ᑠ἟ ு௓, ࿴⏣ ᩔྖ,ෆᇼ 㞝௓, ᑿෆ ኱ᚿ, すᓥ ᬡᙪ, ㏄ ⣧୍, ᪂㇂ ┤ᶞ, 㐲▮ ᔞ, ྡᓥ ᝆᓠ, ᑠᯘ Ṋ,኱ಖᮌ ၨ௓, ཎ⏣ ᾈᚨ, ᆏᕳ ኖ, ኱ᶫ ୍㍤, ཎ⏣ ⤖ⰼ, ᅵᒱ ඾Ꮚ ࠕTKI ࡟᢬ᢠᛶࢆ
♧ࡋࠊྠ✀⛣᳜ᚋ᪩ᮇ࡟ CNS ෌Ⓨࢆㄆࡵࡓ CML ࡢ 1 ౛ࠖ(୍♫)᪥ᮏ⾑ᾮᏛ఍ᮾி஦ົᒁ

⮫ᗋ⾑ᾮ-., 63,5: 497- 497 202205
10. Sanna Vuoristo, Shruti Bhagat, Christel Hyd n-Granskog, Masahito Yoshihara, Lisa Gawriyski,
Eeva-Mari Jouhilahti, Vipin Ranga, Mahlet Tamirat, Mikko Huhtala, Ida Kirjanov, Sonja
Nyk nen, Kaarel Krjut kov, Anastassius Damdimopoulos, Jere

eltner, Kosuke Hashimoto,G.Recher, Sini Ezer, Priit Paluoja, Pauliina Paloviita, Yujiro Takegami, Ai Kanemaru, Karolina
Lundin, Tomi T Airenne, Timo Otonkoski, Juha S Tapanainen, Hideya Kawaji, Yasuhiro
Murakawa, Thomas R B rglin, Markku Varjosalo, Mark S Johnson, Timo Tuuri, Shintaro
Katayama, Juha Kere. DU 4 is a multifunctional factor priming human embryonic genome
activation. iScience., 254, 104137-104137, 20220415. (doi.org/10.1016/j.isci.2022.104137)
11. Naoko Yoshizawa-Sugata, Hisao Masai. Histone Modification Analysis of Low-Mappability
Regions, Methods in Molecular Biolog., 2519, 163 185 2023.
(doi.org/10.1007/978-1-0716-2433-3 18)
12. Ryuichi Nakagawa, Kei Takasawa, Maki Gau, Atsumi Tsuji-Hosokawa, Hideya Kawaji, Yasuhiro－1 1－

Murakawa, Shuji Takada, Masashi Mikami, Satoshi Narumi, Maki Fukami, Rajini Sreenivasan,
Tetsuo Maruyama, Elena Tucker, Liang hao, Josephine Bowles, Andrew Sinclair, Peter
Koopman,Yoshihide Hayashizaki, Tomohiro Morio, Kenichi Kashimada.

Two ovarian candidate

enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations
identified in ovarian insufficiency. Hum. Mol. Genet. 31, 2223 2235,2022.
(doi.org/10.1093/hmg/ddac023)
13. Akane Yoshikawa, Itaru Kushima, Mitsuhiro Miyashita, Kazuhiro Suzuki, Kyoka Iino, Kazuya
Toriumi, Yasue Horiuchi, Hideya Kawaji, Norio Ozaki, Masanari Itokawa, Makoto Arai. Exonic
deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype, PLoS One 17,
e0270506,2022. (doi: 1a0.1371/journal.pone.0270506)
14. Tomomi Morikawa, Tatsuki Fukami, Saki Gotoh-Saito, Masataka Nakano, Miki Nakajima.
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and lipid metabolism. Biochem. Pharmacol. 199, 115010,20220318, (doi:
10.1016/j.bcp.2022.115010)
15. Subhendu K Das, Vlandislav Kuzin, Donald P Cameron, Suzanne Sanford, Rajiv Kumar Jha,uqin Nie, Marta Trullols Rosello, Ronald Holewinski, Thorkell Andresson, Janisniewski,

Toyoaki Natsume, David H Price, Brian A Lewis, Fedor Kouzine, David Levens, Laura Baranello.
MYC assembles and stimulates topoisomerases 1 and 2 in a topoisome ,Mol. Cell 82, 140

158.e12, 20211209,( doi: 10.1016/j.molcel.2021.11.016)
16. Saki Gotoh-Saito, Daichi Sadato, Futoshi Shibasaki. INT6/eIF3e represses E-cadherin expression
through HIF2a in lung carcinoma A549 cells.

enes to Cells 27, 689 705, 20220929,( doi:

10.1111/gtc.12984)

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼⥲ㄝ
1. ྜྷᕝⲁࡽࠊ᪥ᮏ⢭⚄⚄⤒Ꮫ఍II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 10 ௳㸧⮬⏤ᥖ㍕－1－

㸦ィ 1 ௳㸧

1.

ཎ㞝୍㑻,

ྜྷἑ┤Ꮚ, ᕝ㊰ⱥဢ ♽ඛ㌿෗ไᚚࡢᐇ㦂ⓗ᚟ඖ࡟ᇶ࡙ࡃ㑇ఏᏊࡢ๰ᡂ࣭ᾘ

ኻ㐣⛬ࡢゎ᫂ 2022 ᖺᗘࠕඛ㐍ࢤࣀ࣒ᨭ᥼ࠖᣑ኱⌜఍㆟ 2023/1/19㹼2023/1/20 ࣃࢩࣇ࢕ࢥᶓ὾/⚄ዉᕝ┴ᶓ὾ᕷ
2.

ཎ㞝୍㑻,

㰺⸨⣪ᕼ, ࿴⏣ᾴᏊ,FLAT-seq: Full-Length cDNAᕝ㊰ⱥဢ

sequencing with Adapative sampling of TSS ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼

3.

2022/12/2

ᖥᙇ࣓ࢵࢭ/༓ⴥ┴ྜྷἑ┤Ꮚ,ཎ㞝୍㑻, ࿴⏣ᾴᏊ,ᕝ㊰ⱥဢ㌿෗⤊⤖Ⅼ㏆ഐ㡿ᇦࢆᑐ㇟࡜ࡋࡓࠊ㌿෗㛤ጞไᚚάᛶࡢ⥙⨶ⓗゎᯒ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍

2022/11/30㹼2022/12/2

ᖥᙇ࣓ࢵࢭ/༓ⴥ┴4.

ᕝ㊰ⱥဢ Unified identification of transcribed cis-regulatory elements and theirinteractions ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴

5.

㰺⸨⣪ᕼ,

࿴⏣ᾴᏊ, ᕝ㊰ⱥဢCAGE ゎᯒ࡟ࡼࡿ⸆≀௦ㅰ㓝⣲ UGT1A1 㑇ఏᏊࡢ᪂つ࢚ࣥࣁࣥࢧ࣮㡿ᇦࡢྠᐃ ➨ 45 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2022/11/30㹼2022/12/2 ᖥᙇ࣓ࢵࢭ/༓ⴥ┴6.

ᕝ㊰ⱥဢ

FANTOM5 ࡟࠾ࡅࡿ UCSC Genome Browser Track Hub ࡢ฼⏝࡜ᒎ㛤

Bio”Pack”athon 20222022/9/2
7.

ཎ㞝୍㑻 㑇ఏᏊࡢ㐠࿨ࢆᕥྑࡍࡿࢤࣀ࣒ࡢሙ ᅜ❧㑇ఏᏛ◊✲఍ࠕ⏕࿨⛉Ꮫࢆᨭ࠼ࡿศ
Ꮚ⣔⤫Ꮫࠖ 2022/8/3㹼2022/8/48.

ᅜ❧㑇ఏᏛ◊✲ᡤ/㟼ᒸ┴୕ᓥᕷཎ㞝୍㑻 ୙ᆒ୍࡞ࢤࣀ࣒ࡢሙ࡛ࡢ✺↛ኚ␗࡜㑇ఏᏊ㐍໬ࡢ࣮ࣔࢻ ᪥ᮏ㐍໬Ꮫ఍ᖺ኱
఍

9.

࢜ࣥࣛ࢖ࣥ

➨ 24 ᅇ἟ὠ኱఍ 2022/8/4㹼2022/8/7

ᕝ㊰ⱥဢ,
Ꮫ఍

ᅜ❧㑇ఏᏛ◊✲ᡤ௚/㟼ᒸ┴୕ᓥᕷᘅ℩┤Ẏ ࢝ࢽࢡ࢖ࢨࣝ ᶆ‽ࢤࣀ࣒㓄ิ࣭㑇ఏᏊࣔࢹࣝࡢ᭦᪂᪥ᮏ᰾㓟་⸆➨㸵ᅇᖺ఍ 2022/7/31㹼2022/8/3

10. Takeya Kasukawa, Scott࠾ⲔࡢỈࢯࣛࢩࢸ࢕࢝ࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮

alker, Akira Hasegawa, Nishad Thalhath,Toyoyuki Takada, Hiroshi

Masuya, Hideya Kawaji, Shinya Oki. A new integrated transcriptional regulation data platform
with cis-regulatory elements,trans-factors and epigenomic states, IMGC,202303,Ⲉᇛ┴ࡘࡃࡤᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧

IV. ≉グ஦㡯－1－ࣉࣟࢪ࢙ࢡࢺྡ

♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮࣭ᚰࡢ೺ᗣࣘࢽࢵࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 27 ௳㸧
1Nakanishi M, Richards M, Stanyon D, Yamasaki S, Endo K, Sakai M, Yoshii H, Nishida A (2022)
Adolescent Carers Psychological Symptoms and Mental

ell-being During the COVID-19:

Longitudinal Study Using Data from the UK Millennium Cohort Study. Journal of Adolescent
Health, 2022 Jun 70(6):877-884.

2

doi: 10.1016/j.jadohealth.2022.01.228

Nakanishi M, Yamasaki S, Niimura J, Endo K, Nakajima N, Stanyon D, Baba K, Oikawa
N, Hosozawa M, Ando S, Hiraiwa-Hasegawa M, Kasai K, Nishida A (2022) Association
between maternal perceived capacity in life and physical punishment of teenage children:a longitudinal analysis of a population-based cohort in Tokyo, Japan. BMJ Open, 2022
Mar 17 12(3):e058862. doi: 10.1136/bmjopen-2021-058862

3

Tetsuka J, Matsukawa T, Yokoyama K, Yamasaki S, Ando S, Nishida
A, Hiraiwa-Hasegawa M, Kasai K (2022) Effects of trace elements on anthropometriccharacteristics of children: Cobalt and childhood body mass index. Juntendo Medical
Journal, 68 (3) 251-260. doi: 10.14789/jmj.JMJ21-0043-OA

4

Suzuki K, Yamasaki S, Miyashita M, Ando S, Toriumi K, Yoshikawa A, Nakanishi M,
Morimoto Y, Kanata S, Fujikawa S, Endo K, Koike S, Usami S, Itokawa M,

ashizuka S,

Hiraiwa-Hasegawai M, Herbert Meltzer H, Kasai K, Nishida A, Arai M (2022) Role ofadvanced glycation end products in the longitudinal association between muscularstrength and psychotic symptoms among adolescents. Schizophrenia (Heidelb), (2022)
8:44. doi: 10.1038/s41537-022-00249-5
5Endo K, Stanyon D, Yamasaki S, Nakanishi M, Niimura J, Kanata S, Fujikawa S,
Morimoto Y, Hosozawa M, Baba K, Oikawa N, Nakajima N, Suzuki K, Miyashita M,
Ando S, Hiraiwa-Hasegawa M, Kasai K, Nishida A (2022) Self-reported maternal
parenting stress from 9m is longitudinally associated with child ADHD symptoms at age
12: findings from a population-based birth cohort study. Frontiers in Psychiatry, 2022
Apr 28 13:806669. eCollection 2022. doi: 10.3389/fpsyt.2022.806669

－1

－

6

Kasai K, Yagishita S, Tanaka S, Koike S, Murai T, Nishida A, Yamasaki S, Ando S,
Kawakami N, Kanehara A, Morita K, Kumakura Y, Takahashi Y, Sawai Y, Uno A,
Sakakibara E, Okada N, Okamoto Y, Nochi M, Kumagaya S, Fukuda M (2022)
Personalized values in life as point of interaction with the world:developmental/neurobehavioral basis and implications for psychiatry. Psychiatry andClinical Neurosciences Reports, 1(2):e12. doi: 10.1002/pcn5.12

7

Nagaoka D, Tomoshige N, Ando S, Morita M, Kiyono T, Kanata S, Fujikawa S, Endo K,
Yamasaki S, Fukuda M, Nishida A, Hiraiwa-Hasegawa M, Kasai K (2022) Being praisedfor prosocial behaviors longitudinally reduces depressive symptoms in early adolescents:
A population-based cohort study. Frontiers in Psychiatry, 2022 May 17 13:865907.
eCollection 2022. doi: 10.3389/fpsyt.2022.865907

8

Nakanishi M, Yamasaki S, Ando S, Endo K, Richards M, Hiraiwa-Hasegawa M, Kasai K,
Nishida A (2022) Neighborhood Social Cohesion and Dementia-Related Stigma Among
Mothers of Adolescents in the Pre- and Current COVID-19 Period: An Observational
Study Using Population-Based Cohort Data. Journal of Alzheimer's Disease, 88 (2) 493
502. doi: 10.3233/JAD-220043

9

Kiyono T, Ando S, Morishima R, Fujikawa S, Kanata S, Morimoto Y, Endo K, Yamasaki
S, Hiraiwa-Hasegawa M, Nishida A, Kasai K (2022) Sex-Based Differences in theLongitudinal Association between Autistic Traits and Positive Psychotic Experiences in
Adolescents: A Population-Based Cohort Study. Schizophrenia Research, 2022 Jun
10 246:1-6. Epub 2022 Jun 10. doi: 10.1016/j.schres.2022.05.027

10 Niimura J, Nakanishi M, Yamasaki S, Ando S, Kanata S, Fujikawa S, Morimoto Y, Endo
K, Hiraiwa-Hasegawa M, Kasai K, Nishida A (2022) Maternal parenting stress from birth
to 36 months, maternal depressive symptoms, and physical punishment to 10-year-old
children: A population-based birth cohort study. Social Psychiatry and Psychiatric
Epidemiology, 2022 Jul 5, 2022 Nov 57(11):2207-2215. Epub 2022 Jul 5.
doi: 10.1007/s00127-022-02319-6
11 Nakanishi M, Nakashima T, Miyamoto Y, Yamasaki S, Nishida A (2022) Family
caregivers concerns about advance care planning for home-dwelling people withdementia: a cross-sectional observational study in Japan. BMC Palliative Care, 21(1).
doi: 10.1186/s12904-022-01008-0
12 DeVylder J (2022) Suicide Risk Prediction in Clinical Settings Additional
Considerations for Face-to-Face Screening and Machine Learning
Approaches. JAMA Network Open, 2022 5(5):e2212106.

－1 5－doi: 10.1001/jamanetworkopen.2022.12106
13 Kanehara A, Morishima R, Takahashi Y, Koike H, Usui K, Sato S, Uno A, Sawai Y,
Kumakura Y, Yagishita S, Usami S, Morita M, Morita K, Kanata S, Okada N, Yamasaki
S, Nishida A, Ando S, Koike S, Shibuya T, Joseph S, Kasai K (2022) Young carers inJapan: Reliability and validity testing of the BBC/University of Nottingham young carers
survey questionnaire and prevalence estimation in 5,000 adolescents. Psychiatry andClinical Neurosciences Reports, 1(3):e46. doi: 10.1002/pcn5.46
14 Nakanishi M, Yamasaki S, Endo K, Ando S, Sakai M, Yoshii H, Nishida A (2022)
Suicide rates during the COVID-19 pandemic in Japan from April 2020 to December
2021. Psychiatry Research, 2022 Aug 7 316:114774. Epub 2022 Aug 7.
doi: 10.1016/j.psychres.2022.114774
15 Ando S, Suzuki H, Matsukawa T, Usami S, Muramatsu H, Fukunaga T, Yokoyama K,
Okazaki Y, Nishida A (2022) Comparison of lithium levels between suicide andnon-suicide fatalities:cross-sectional study. Translational Psychiatry, (2022) 12:466.
doi: 10.1038/s41398-022-02238-9
16 Tabata K, Miyashita M, Yamasaki S, Toriumi K, Ando S, Suzuki K, Endo K, Morimoto
Y, Tomita Y, Yamaguchi S, Usami S, Itokawa M, Hiraiwa-Hasegawa M, Takahashi H,
Kasai K, Nishida A, Arai M (2022) Hair zinc levels and psychosis risk among
adolescents. Schizophrenia (Heidelb), (2022) 8:107. doi: 10.1038/s41537-022-00307-y
17 Hosozawa M, Cable N, Yamasaki S, Ando S, Endo K, Usami S, Nakanishi M, Niimura J,
Nakajima N, Baba K, Oikawa N, Stanyon D, Suzuki K, Miyashita M, Iso H,
Hiraiwa-Hasegawa M, Kasai K, Nishida A (2022) Predictors of chronic loneliness duringadolescence: A Population-based Cohort Study. Child and Adolescent Psychiatry and
Mental Health, 2022 Dec 21 16(1):107. doi: 10.1186/s13034-022-00545-z
18 DeVylder J, Yamasaki S, Ando S, Miyashita M, Endo K, Baba K, Niimura J, Nakajima N,
Yamaguchi S, Stanyon D, Narita , Schiffman J, Hiraiwa-Hasegawa M, Kasai K
Nishida A (2023) Attributes of auditory hallucinations that are associated with self-harm:
A prospective cohort study. Schizophrenia Research, 2023 Jan 251:30-36. Epub 2022
Dec 16. doi: 10.1016/j.schres.2022.12.008
19 DeVylder J, Anglin D, Munson M.R, Nishida A, Oh H, Marsh J, Narita , Bareis N,
Fedina L (2023) Ethnoracial variation in risk for psychotic experiences. Schizophrenia
Bulletin, 2023 Mar 15 49(2):385-396. doi: 10.1093/schbul/sbac171
20 Stanyon D, DeVylder J, Yamasaki S, Yamaguchi S, Ando S, Usami S, Endo K, Miyashita
M, Kanata S, Morimoto Y, Hosozawa M, Baba K, Nakajima N, Niimura J, Nakanishi M,－1 6－

Hiraiwa-Hasegawa M, Kasai K, Nishida A (2023) Auditory hallucinations andself-injurious behavior in general population adolescents: modeling within-person effects
in the Tokyo Teen Cohort. Schizophrenia Bulletin, 2023 Mar 15 49(2):329-338.
doi: 10.1093/schbul/sbac155
21 Davies S.J.C, Bolea-Alamanac B, Endo K, Yamamoto Y, Yamasaki S, Malins A, Evans J,
Sullivan S, Ando S, Nishida A, Kasai K (2023) Urban factors and mental healthsymptoms in children of the Tokyo Early Adolescence Survey impact of proximity torailway stations. Journal of Transport & Health, 28(2023)
101564. doi: 10.1016/j.jth.2022.101564
22 Nakanishi M, Tanaka T, Nishida A, Mandai N, Kitamura N, Yoshii H (2023) An online
intervention to promote mental health literacy for psychosis among parents of adolescents:
A pilot randomised controlled trial. Early Intervention in Psychiatry, 2023 Jan 10. Online
ahead of print. doi: 10.1111/eip.13390
23 Tanaka R, Ando S, Kiyono T, Minami R, Endo K, Miyashita M, Yamasaki S, Kanata S,
Fujikawa S, Hiraiwa-Hasegawa M, Nishida A, Kasai K (2023) The longitudinal
relationship between dissociative symptoms and self-harm in adolescents: A
population-based cohort study. European Child & Adolescent Psychiatry, 2023 Mar 8.
Online ahead of print. doi: 10.1007/s00787-023-02183-y
24 Nakanishi M, Ogawa A, Sakai M, Yoshii H, Yamasaki S, Nishida A (2023) uality ofEnd-of-Life Care for Older Adults with Dementia During COVID-19 Pandemic. Journalof the American Medical Directors Association, 2023 Mar 13 S1525-8610(23)00280-3.
Epub 2023 Mar 13. doi: 10.1016/j.jamda.2023.03.001
25 Nakanishi M, Ogawa A, Sakai M, Yoshii H, Miyashita M, Yamasaki S, Nishida A (2023)
Depression and Anxiety in Older Adults with Dementia During the COVID-19
Pandemic. Journal of Alzheimer's Disease Reports, 7(1):307-315.
doi: 10.3233/ADR-230019
26 Tomita Y, Suzuki K, Yamasaki S, Toriumi K, Miyashita M, Ando S, Endo K,Yoshikawa
A, Tabata K, Usami S, Hiraiwa-Hasegawa M, Itokawa M, Kawaji H, Kasai K, Nishida A,
Arai M (2023) Urinary exosomal microRNAs as predictive biomarkers for persistent
psychotic-like experiences. Schizophrenia (Heidelb), 2023 Mar 11 9(1):14.
doi: 10.1038/s41537-023-00340-5
27 Nakanishi M, Nakashima T, Miyamoto Y, Sakai M, Yoshii H, Syudo Yamasaki S,
Nishida A (2023) Association between advance care planning and depressive symptoms
among community-dwelling people with dementia: An observational cross-sectional study－1 7－

during the COVID-19 pandemic in Japan. Frontiers in Public Health, 2023 Mar
30 11:915387. doi: 10.3389/fpubh.2023.915387
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 0 ௳㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯㸺ᮾி㒔⚟♴ಖ೺ᒁ࣭ឤᰁ⑕ᑐ⟇㒊㸼1.

ᮾி㒔 iCDC ࢔ࢻࣂ࢖ࢨ࣮࣮ࣜ࣎ࢻ␿Ꮫ࣭බ⾗⾨⏕ࢳ࣮࣒ ࣓ࣥࣂ࣮㸦す⏣㸧

2.

ᮾி㒔 iCDC ឤᰁண

3.

ᮾி㒔᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ࣔࢽࢱࣜࣥࢢ఍㆟࡬ࡢฟᖍせㄳ

4.

ᮾி㒔᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇ᮏ㒊఍㆟࡬ࡢฟᖍせㄳ

5.

ᮾி㒔᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇ᑂ㆟఍࡬ࡢฟᖍせㄳ

6.

㒔ෆ୺せ⦾⳹⾤⁫␃ேཱྀศᯒ࣭๪▱஦ࣈ࣮ࣜࣇ࢕ࣥࢢ

ࢩ࣑࣮ࣗࣞࢩࣙࣥࢱࢫࢡࣇ࢛࣮ࢫ ࣓ࣥࣂ࣮㸦す⏣㸧㸺ᮾி㒔⚟♴ಖ೺ᒁ࣭㧗㱋♫఍ᑐ⟇㒊㸼7.

ᮾி㒔ㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛ᥎㐍஦ᴗ࣭ࣇ࢛࣮ࣟ࢔ࢵࣉ◊ಟㅮᖌ㸦す⏣࣭ᒣ㷂࣭᪂ᮧ㸧－1－㸺ᮾி㒔⚟♴ಖ೺ᒁ࣭ᑡᏊ♫఍ᑐ⟇㒊㸼8.

ᮾி㒔ඣ❺⹢ᚅண㜵ⓗᨭ᥼ࣔࢹࣝࡢ㛤Ⓨ࡜ຠᯝ᳨ド஦ᴗ ࣇ࢓࣑࣮ࣜࢧ࣏࣮ࢺ࣮࣮࣡࢝
⫱ᡂ◊ಟ㸦す⏣࣭ᒣ㷂࣭ᐑୗ࣭᪂ᮧ࣭㤿ሙ࣭୰ᓥ㸧㸺ཌ⏕ປാ┬࣭᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇࢔ࢻࣂ࢖ࢨ࣮࣮ࣜ࣎ࢻ㸼9.

ཌ⏕ປാ┬ ᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇࢔ࢻࣂ࢖ࢨ࣮࣮ࣜ࣎ࢻ࣭ࢹ࣮ࢱゎᯒࢳ࣮࣒࣓ࣥࣂ࣮㸦す⏣࣭ᒣ㷂㸧

10. ཌ⏕ປാ┬ ᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇࢔ࢻࣂ࢖ࢨ࣮࣮ࣜ࣎ࢻ఍㆟ ᗙ㛗࡟ࡼࡿฟᖍせㄳ㸦す⏣㸧㸺ཌ⏕ປാ┬࣭⪁೺ᒁ㸼
11. ㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛࡢ඲ᅜᬑཬ࡟ྥࡅࡓ᳨ド஦ᴗጤဨ㸦す⏣㸧

㸺ෆ㛶ᐁᡣ㸼
12. ෆ㛶ᐁᡣ㛗ᐁࣈ࣮ࣜࣇ࢕ࣥࢢ㸦す⏣࣭ᒣ㷂㸧
13. ᪂ᆺࢥࣟࢼ࢘࢕ࣝࢫឤᰁ⑕ᑐ⟇ᢸᙜ኱⮧ࣈ࣮ࣜࣇ࢕ࣥࢢ㸦す⏣࣭ᒣ㷂㸧㸺ᩥ㒊⛉Ꮫ┬㸼
14. Ꮚ࡝ࡶࡓࡕࡢ࢙࢘ࣝࣅ࣮࢖ࣥࢢࡢᅾࡾ᪉࡟㛵ࡍࡿ◊✲఍ ጤဨ㸦す⏣㸧㸺OECD㸸⤒῭༠ຊ㛤Ⓨᶵᵓ㸼
15. OECD Future of Education and Skills 2030 Project Thought Leader (す⏣)－1－ࣉࣟࢪ࢙ࢡࢺྡ

♫఍೺ᗣ་Ꮫ◊✲ࢭࣥࢱ࣮࣭㞴⑓ࢣ࢔┳ㆤࣘࢽࢵࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 3 ௳㸧
1.

Matsuda C, Shimizu T,Nakayama Y, Haraguchi M, Hakuta C, Hidaka R, Nishiyama A,
Numayama T. Clinical relevance of macroglossia to disease progression in ventilation dependentpatients with advanced ALS. Neurological Sciences., 20230130. (doi.org/10.1007/s10072-02306646-7)

2㸬ᯈᇉ ࡺࡳ, ୰ᒣ ඃᏘ, ཎཱྀ 㐨Ꮚ, ᯇ⏣ ༓᫓, ᑠ಴ ᮁᏊ, ➟ཎ ᗣ௦, ᑠ᳃ ဴኵࠕᅾᏯே
ᕤ࿧྾ჾ౑⏝ᝈ⪅ᨭ᥼஦ᴗࢆ฼⏝ࡋ࡚࠸ࡿᝈ⪅ࡢ≉ᚩ࡜ゼၥ┳ㆤᖌ࡟ࡼࡿホ౯ࠖ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ. 27, 3: 86-94, 202212.
3.

Kamei T, Yamamoto Y, Nakayama Y, Kanamori T, Harada T, Nishio K, Nakano Y, Fetters DM.
Prospective fully longitudinal mixed methods evaluation to improve health literacy of older adults
with chronic conditions through home-monitoring-based telenursing in Japan. Annals of Mixed
Methods Research., 1, 2: 111- 135, 20220820. (doi.org/10.51108/ammr.1.2 111)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 12 ௳㸧1㸬 ୰ᒣ ඃᏘ , ᯈᇉ ࡺࡳ, ཎཱྀ 㐨Ꮚ, ᯇ⏣ ༓᫓, ᑠ಴ ᮁᏊ. 㞴⑓┳ㆤࡢຠᯝⓗ⥅⥆௓ධ㹼㞴⑓┳ㆤᖌࡢά⏝࡟ࡼࡿ㞴⑓ᨭ᥼ࡢ㉁ྥୖࢆ┠ᣦࡋ࡚㹼2022 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ
஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌ 
2㸬 ཎཱྀ 㐨Ꮚ, ➟ཎ ᗣ௦, ୰ᒣ ඃᏘ, ᑠ಴ ᮁᏊ, ᯇ⏣ ༓᫓, ᯈᇉ ࡺࡳ. 㞴⑓⒪㣴⤒㐣࡟࠾ࡅࡿᨭ᥼ᶵ㛵➼ࡢ㐃ᦠ. 2022 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌
3㸬 ᑠ಴ ᮁᏊ㸪༓ⴥ ᆂᏊ, ᑠ᳃ ဴኵ. 㞴⑓ಖ೺࡟࠾ࡅࡿᆅᇦᨭ᥼యไᩚഛࡢ᥎㐍̿⅏ᐖᑐ⟇ᇶᮏἲᨵṇᚋࡢ⅏ᐖ᫬ᨭ᥼యไࡢ᥎㐍̿. 2022 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ
㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩.p4753.2023
4㸬 ༓ⴥ ᆂᏊ㸪ᑠ಴ ᮁᏊ㸪ᑠ᳃ ဴኵ. 㞴⑓┦ㄯᨭ᥼ࢭࣥࢱ࣮ࡢయไ࡜௚ᶵ㛵㐃ᦠࡢᆒ㟏໬࡟㛵ࡍࡿせᅉศᯒ. 2022 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊－1－✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩.p54-61.2023
5㸬 ⓑ஭ ᏕᏊ, ཎཱྀ 㐨Ꮚ, ௒ᮧ ᩥ඾, 㙊⏣ ⿱Ꮚ ௚. ௧࿴ 5 ᖺᗘཌ⏕ປാ┬⪁ேಖ೺஦ᴗ᥎
㐍㈝➼⿵ຓ㔠 EPA ࡟ᇶ࡙ࡃእᅜே௓ㆤ⚟♴ኈೃ⿵⪅ࡀཷࡅධࢀ᪋タ࡛⩦ᚓࡍࡿ௓ㆤᢏ
⾡ࡢ⤫୍ⓗ࡞ホ౯᪉ἲࢆ☜❧ࡍࡿࡓࡵࡢㄪᰝ◊✲஦ᴗሗ࿌᭩, ᅜ㝿ཌ⏕஦ᴗᅋ.
6㸬 ▼ᒣ 㯇Ꮚ㸦᳨ウጤဨ㛗㸧, 㐲⸨ ᚁஓ, ཎཱྀ 㐨Ꮚ ௚. ௧࿴ 5 ᖺᗘཌ⏕ປാ┬⪁ேಖ೺೺ᗣ᥎㐍➼஦ᴗࠕ௓ㆤᨭ᥼ᑓ㛛ဨࡢ㈨㉁ྥୖ࡟㈨ࡍࡿ◊ಟ➼ࡢᅾࡾ᪉࡟㛵ࡍࡿㄪᰝ◊✲஦ᴗࠖሗ࿌᭩, ᪥ᮏ⥲◊.
7㸬 ୰ᒣ ඃᏘ, 㞴⑓┳ㆤᖌไᗘࡢᵓ⠏࡟ྥࡅࡓྲྀࡾ⤌ࡳ.≉㞟ճ୍⯡♫ᅋἲே᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ࣭㞴⑓┳ㆤᖌไᗘࡢࡇࢀࡲ࡛ࡢṌࡳ࡜άື.᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ 27(1).37-41.2022.
8㸬 ᶫᮏ ె௦Ꮚ, 㧗㔝 ඖ, ୰ᒣ ඃᏘ.㞴⑓ࡢぶࢆᣢࡘᏊ౪ࡓࡕ ࣖࣥࢢࢣ࢔࣮ࣛࡢ⏕ࡲࢀࡿሙᡤ࠿ࡽ㹼.㞴⑓࡜ᅾᏯࢣ࢔.27㸦11㸧.40-42.2022  
9㸬 ཎཱྀ 㐨Ꮚ, 㜿㒊 㐩ဢ. 㞴⑓⒪㣴ᨭ᥼࡟࠾ࡅࡿ⥅⥆ⓗᨭ᥼ᶵ⬟࡜ᨭ᥼ᶵ㛵㐃ᦠࡢᐇែ, 㞴⑓࡜ᅾᏯࢣ࢔.26-29.5.
10㸬 ཎཱྀ 㐨Ꮚ㸦ศᢸᇳ➹㸧. 㠀౵くⓗ㝧ᅽ᥮Ẽ⒪ἲ㸦NPPV㸧ࢆཷࡅࡿ⒪㣴⪅ࡢ┳ㆤ, p190197, ⣔⤫┳ㆤᏛㅮᗙ ᆅᇦ࣭ᅾᏯ┳ㆤㄽ, ་Ꮫ᭩㝔. 
11㸬 ཎཱྀ 㐨Ꮚ㸦ศᢸᇳ➹㸧. 㞴⑓ಖ೺άື, p152-157, ಖ೺ᖌᅜᐙヨ㦂ࡢࡓࡵࡢࣞࣅ࣮ࣗࣈ
ࢵࢡ 2022 ➨ 22 ∧, ་⒪᝟ሗ⛉Ꮫ◊✲ᡤ㸦⦅㞟㸧, ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔. 
12㸬 ཎཱྀ 㐨Ꮚ㸦ศᢸᇳ➹㸧. 㞴⑓ಖ೺άື,281-293, ࢡ࢚ࢫࢳ࣭ࣙࣥࣂࣥࢡಖ೺ᖌᅜᐙヨ㦂ၥ㢟ゎㄝ 2022 ➨ 14 ∧, ་⒪᝟ሗ⛉Ꮫ◊✲ᡤ㸦⦅㞟㸧, ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 3 ௳㸧
1. ୰ᒣ ඃᏘ. ᮾி㒔་ᖌ఍㞴⑓┦ㄯ఍ࡢࡇࢀࡲ࡛ 㹼㞴⑓᪋⟇࡜ࡢ㛵㐃࠿ࡽ㹼➨ 27 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍Ꮫ⾡㞟఍㺂ࢩ࣏ࣥࢪ࣒࢘ 1.㞴⑓┦ㄯࡢ㌶㊧࠿ࡽ 2022.8.18 ᮾி(web)2. ୰ᒣ ඃᏘ, ᅾᏯ⚄⤒㞴⑓࿧྾ࢣ࢔࡟࠾ࡅࡿ┳ㆤࡢᙺ๭.➨ 4 ᅇ᪥ᮏᅾᏯ་⒪㐃ྜᏛ఍,ࣃࢿࣝࢹ࢕ࢫ࢝ࢵࢩࣙࣥ.2022.7.24 ⚄ᡞ
3. ୰ᒣ ඃᏘ㸬⚄⤒㞴⑓ᝈ⪅ࡢ┳ㆤ ᆅᇦ࡛ࡢ⏕άࢆᨭ࠼ࡿࡓࡵ࡟㸬➨ 63 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍㸪ࢩ࣏ࣥࢪ࣒࢘ 33 㞴⑓་⒪ᥦ౪యไ࡜ᆅᇦඹ⏕㹼㞴⑓ἲࡢぢ┤ࡋࢆぢᤣ࠼࡚㹼
2022.5.21 ᮾிࡑࡢ௚ 㸦ィ 20 ௳㸧⮬⏤ᥖ㍕－1 1－࠙ᅜෆᏛ఍㸸ཱྀ₇࣭࣏ࢫࢱ࣮ࠚ
1.

ཎཱྀ 㐨Ꮚ, ୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, ᯈᇉ ࡺࡳ, ᑠ಴ ᮁᏊ. ་⒪ᶵ㛵࡜ゼၥ┳ㆤ஦ᴗᡤࡢ
┳ㆤ㐃ᦠ࡟ࡼࡿᅾᏯ⒪㣴ࣜࢫࢡ⟶⌮ࡢᵓᡂせ⣲, ➨ 12 ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍,
㸦Web 㛤ദ㸧, 2022.11

2.

᳃ᓥ ு, ᯇ⏣ ༓᫓, ᑠ᳃ 㝯ྖ, ΎỈ ಇኵ, ୰ᒣ ඃᏘ, 㧗ᶫ ୍ྖࠕேᕤ࿧྾ჾ⿦╔ᚋ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢࢥ࣮࣍ࢺ◊✲(➨ 1 ሗ) ⤊ᮎᮇࢆ㏄࠼ࡿሙᡤ࡜๗᳨ࡢഃ㠃࠿ࡽࠖ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ఍ᶵ㛵ㄅ,3.

10, 1: 107- 107, 2022.11.

ཎཱྀ 㐨Ꮚ, 㜿㒊 㐩ဢ, ୰ᒣ ඃᏘ, ᑠ಴ ᮁᏊ, ᯇ⏣ ༓᫓, ᯈᇉ ࡺࡳ, ᑠ᳃ ဴኵࠕ㞴⑓⥅⥆ⓗᨭ᥼యไ࡟࠾ࡅࡿᨭ᥼ᶵ㛵ࡢ㐃ᦠࡢㄢ㢟࡟㛵ࡍࡿ㉁ⓗ᳨ウࠖ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ
࣮࣡ࢡᏛ఍ᶵ㛵ㄅ, 10, 1: 98- 98, 2022. 11.

4.

ᯇ⏣ ༓᫓, ୰ᒣ ඃᏘ, ཎཱྀ 㐨Ꮚ, ᯈᇉ ࡺࡳ, ᑠ಴ ᮁᏊ, ዟᒣ ඾Ꮚ, ᳃ᓥ ு, ΎỈ ಇኵ ࠕ㠀౵くⓗ᥮Ẽ⒪ἲࢆᐇ᪋ࡍࡿ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ࢜ࣆ࢜࢖ࢻ౑⏝࡜య᱁ᣦᩘ
࡜ࡢ㛵ಀࠖ(୍♫)᪥ᮏ⚄⤒἞⒪Ꮫ఍

5.

⚄⤒἞⒪Ꮫ., 39, 6: S280- S280, 202210.

ཎཱྀ 㐨Ꮚ, ᮌ⏣ ⪔ኴ, ᯘ ೺ኴ㑻, ᮌᮧ ⱥ⣖, ΎỈ ಇኵ, ᪩எዪ ㈗Ꮚ, ᮏ㛫 Ṋⶶ, ኱ሺ ඃᏊ, ᮧୖ ᮍ᮶, ኱✽ ┿ᘪ, ୕ᮧ ᜨ⨾, ᪂஭ ⋢༡, ▮྿ ࡳࡺࡁ, ቑ⏣ ⌮ᜨ, ྜྷἨ⨾⍛Ꮚ, ሮ ⰋỤ, ዟᒣ ඾Ꮚ, ୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, 㧗ᶫ ୍ྖ ࠕALS/MND ࢭࣥࢱ࣮እ᮶࡟࠾ࡅࡿ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅࡬ࡢከ⫋✀ࢳ࣮࣒࢔ࣉ࣮ࣟࢳࠖ(୍♫)᪥ᮏ⚄⤒἞⒪Ꮫ఍ ⚄⤒἞⒪Ꮫ. 39, 6: S276- S276, 2022.10.

6.

୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, ཎཱྀ 㐨Ꮚ, ᯘ ೺ኴ㑻, ᮌ⏣ ⪔ኴ, ΎỈ ಇኵࠕ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ⾑ᾮᏛⓗᰤ㣴ᣦᶆࡢ᥎⛣࡜ពᛮఏ㐩ࢫࢸ࣮ࢪ࡜ࡢ㛵ಀࠖ(୍♫)᪥ᮏ⚄⤒἞⒪Ꮫ఍ ⚄⤒἞⒪Ꮫ. 39, 6: S275- S275, 2022.10.

7.

ᯘ ೺ኴ㑻, 㛵 ⤮㔛㤶, ୰ᒣ ඃᏘ, ᑠᓥ ฼㤶, ᯇ⏣ ༓᫓, ᮌ⏣ ⪔ኴ, ΎỈ ಇኵ, ᑠ᳃㝯ྖ, 㧗ᶫ ୍ྖࠕ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ㐠ືࢽ࣮ࣗࣟࣥ௨እ࡬ࡢ⑓ኚᣑ኱ࡢ⮫ᗋⓗព⩏ࠖ(୍♫)᪥ᮏ⚄⤒Ꮫ఍

8.

⮫ᗋ⚄⤒Ꮫ. 62, Suppl.: S214- S214, 2022.10.

ᯘ ೺ኴ㑻㸪ᯇ⏣ ༓᫓㸪㛵 ⤮㔛㤶㸪୰ᒣ ඃᏘ㸪ᑠᓥ ฼㤶㸪ᮌ⏣ ⪔ኴ㸪ΎỈ ಇኵ㸪ᑠ᳃ 㝯ྖ㸪㧗ᶫ ୍ྖ㸬➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿయ㔜ῶᑡ࡜⑓⌮Ꮫⓗ࡞⑓ኚᣑ኱ࡢ㛵㐃㸬➨ 18 ᅇ᪥ᮏ⚄⤒ᦤ㣗ᄟୗ࣭ᰤ㣴Ꮫ఍Ꮫ⾡㞟఍㸪ᮾி㸪2022.9

9.

୰ᒣ ඃᏘ㸪ᯇ⏣ ༓᫓㸪ཎཱྀ 㐨Ꮚ㸪ᯘ ೺ኴ㑻㸪ᮌ⏣ ⪔ኴ㸪ΎỈ ಇኵ㸬➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ⾑ᾮᏛⓗᰤ㣴ᣦᶆࡢ᥎⛣㸬➨ 18 ᅇ᪥ᮏ⚄⤒ᦤ㣗ᄟୗ࣭ᰤ㣴Ꮫ఍Ꮫ⾡㞟఍㸪ᮾி㸪2022.9

10. ཎཱྀ 㐨Ꮚ , ୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, ᯘ ೺ኴ㑻, ᮌ⏣ ⪔ኴ, ΎỈ ಇኵ㸬እ᮶㏻㝔ᮇࡢ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ⌫㯞⑷⑕≧࡜㛵㐃ࡋࡓᶵ⬟㞀ᐖ, ⮫ᗋ⤒㐣࡜ࡢ㛵㐃㸬➨ 18 ᅇ᪥ᮏ⚄⤒ᦤ㣗ᄟୗ࣭ᰤ㣴Ꮫ఍Ꮫ⾡㞟఍㸪ᮾி㸪2022.9－1－

11. ᯇ⏣ ༓᫓㸪ᯈᇉ ࡺࡳ㸪୰ᒣ ඃᏘ㸪ཎཱྀ 㐨Ꮚ㸪ᑠ಴ ᮁᏊ㸪ዟᒣ ඾Ꮚ㸪᳃ᓥ ு㸪ΎỈಇኵ㸬Ẽ⟶ษ㛤ୗேᕤ࿧྾⒪ἲࢆᐇ᪋ࡍࡿ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ⭡㒊ྜే⑕㸬➨ 18
ᅇ᪥ᮏ⚄⤒ᦤ㣗ᄟୗ࣭ᰤ㣴Ꮫ఍Ꮫ⾡㞟఍㸪ᮾி㸪2022.9
12. ᯈᇉ ࡺࡳ, ୰ᒣ ඃᏘ, ཎཱྀ 㐨Ꮚ, ᯇ⏣ ༓᫓, ᑠ಴ ᮁᏊ, ᑠ᳃ ဴኵ ࠕ⌧⾜ไᗘୗ࡟࠾
ࡅࡿゼၥ┳ㆤࡢᥦ౪≧ἣ࠿ࡽࡳࡓᅾᏯ⒪㣴୰ࡢ㞴⑓ᝈ⪅࡟ᚲせ࡞┳ㆤࠖ᪥ᮏ㞴⑓┳ㆤᏛ

఍ㄅ. 27, 2: 77- 77, 2022.8.
13.

ᯇ⏣ ༓᫓, ཎཱྀ 㐨Ꮚ, ୰ᒣ ඃᏘ, ᯈᇉ ࡺࡳ, ᑠ಴ ᮁᏊࠕእ᮶㏻㝔ᮇ࡟࠶ࡿ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ⯉ࡢཌࡳ࡜⮫ᗋ⑕≧࡜ࡢ㛵ಀࠖ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ. 27, 2: 74- 74,
2022.8.

14. ཎཱྀ 㐨Ꮚ, 㜿㒊 㐩ဢ, ୰ᒣ ඃᏘ, ᑠ಴ ᮁᏊ, ᯇ⏣ ༓᫓, ᯈᇉ ࡺࡳ, ᑠ᳃ ဴኵࠕ㞴⑓⒪㣴ᨭ᥼࡟࠾ࡅࡿ⥅⥆ⓗᨭ᥼ᶵ⬟࡜ᨭ᥼ᶵ㛵㐃ᦠࡢᐇែࠖ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ. 27, 2:
70- 70, 2022.8.
15. ᑠ಴ ᮁᏊ, ᯈᇉ ࡺࡳ, ཎཱྀ 㐨Ꮚ, ᯇ⏣ ༓᫓, ୰ᒣ ඃᏘࠕ㞴⑓ᝈ⪅ࡢ⅏ᐖᑐ⟇࡟㛵ࡍࡿ㞴⑓ಖ೺άື࡜ㄢ㢟ࠖ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ. 27, 2: 65- 65, 2022.8
16. ᯈᇉ ࡺࡳ, ୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, ཎཱྀ 㐨Ꮚ, ᑠ಴ ᮁᏊ, ᑠ᳃ ဴኵ :ᅾᏯேᕤ࿧྾ჾ
౑⏝ᝈ⪅ᨭ᥼஦ᴗࢆ౑⏝ࡋ࡚࠸ࡿᝈ⪅ࡢ≉ᚩ࡜ゼၥ┳ㆤࡢ≧ἣ㸪➨ 27 ᅇ᪥ᮏᅾᏯࢣ࢔Ꮫ
఍Ꮫ⾡㞟఍㸪➨ 27 ᅇ᪥ᮏᅾᏯࢣ࢔Ꮫ఍Ꮫ⾡㞟఍ㅮ₇ᢒ㘓㞟.74,2022.7,WEB
17. ᯈᇉ ࡺࡳ, ୰ᒣ ඃᏘ, ᯇ⏣ ༓᫓, ཎཱྀ 㐨Ꮚ, ᑠ಴ ᮁᏊ, ᑠ᳃ ဴኵ :ゼၥ┳ㆤᖌࡀ㞴⑓ᝈ⪅࡟ᚲせ࡞ゼၥ┳ㆤ㔞ࢆุ᩿ࡋࡓせᅉ㸪➨ 12 ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍,㸦Web㛤ദ㸧, 2022.11
18. ᯇ⏣ ༓᫓, ୰ᒣ ඃᏘ㸪ΎỈ ಇኵ㸪ཎཱྀ 㐨Ꮚ㸪ᯈᇉ ࡺࡳ㸪ᑠ಴ ᮁᏊ㸪ᑠ᳃ 㝯ྖ㸬➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ㑇᪘ࡢ⑓⌮ゎ๗ࡢᤊ࠼᪉㸬➨ 63 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍㸪ᮾி㸪2022㸦5㸧
19. ΎỈ ಇኵ㸪ᮌ⏣ ⪔ኴ, ᮌᮧ ⱥ⣖㸪ᕝῧ ൉ஓ㸪᳃ᓥ ு㸪ᮧᒣ ᫂ᕼ㸪୰ᒣ ඃᏘ㸪㧗ᶫ୍ྖ㸬➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ offset ₯᫬࠿ࡽồࡵࡓṇ୰⚄⤒㐠ືఏᑟ㏿ᗘ࡜⏕࿨ணᚋ㸬➨ 63 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍㸪ᮾி㸪2022㸦5㸧
20. ᯘ ೺ኴ㑻㸪㛵 ⤮㔛㤶㸪୰ᒣ ඃᏘ㸪ᑠᓥ ฼㤶㸪ᮌ⏣ ⪔ኴ㸪ΎỈ ಇኵ㸪ᑠ᳃ 㝯ྖ㸪㧗ᶫ ୍ྖ㸬➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ㐠ືࢽ࣮ࣗࣟࣥ௨እ࡬ࡢ⑓ኚᣑ኱ࡢ⮫ᗋⓗព⩏㸬➨ 63 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍⥲఍Ꮫ⾡◊✲఍㸪ᮾி㸪2022.

－1－III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 41 ௳㸧
1.

୰ᒣ ඃᏘ㸬ࡑࡢேࡽࡋࡉࢆᨭ࠼ࡿ
ㆤᐇ㊶ຊࢆ㧗ࡵࡿ D㞴⑓┳ㆤࢣ࢔ࡢ☜❧㸬➨ 21 ᅇ JANS ࢭ࣑ࢼ࣮ ┳ࡢ௒࡜ࡇࢀ࠿ࡽ㸸ࢹ࣮ࢱ࣭ࢹࢪࢱࣝᢏ⾡ࡢᡓ␎ⓗά⏝ࡢࣄࣥࢺࢆ

Ꮫࡰ࠺.᪥ᮏ┳ㆤ⛉ᏛᏛ఍㸦࢜ࣥࢹ࣐ࣥࢻ◊ಟ㸧࠙ᣍᚅㅮ₇ࠚ
2.

୰ᒣ ඃᏘ.

HMV ゼၥ┳ㆤࡢᐇ㝿, 2022 ᖺᗘ ᅾᏯேᕤ࿧྾ჾ࡟㛵ࡍࡿㅮ⩦఍, 2022.3

㸦web 㛤ദ㸧
࠙ᣍᚅㅮ₇ࠚ
3.

୰ᒣ ඃᏘ. 㐠ືࢽ࣮ࣗࣟࣥ⑌ᝈࡢ⑕≧࡟ࡳ࡞ࡉࢀ࡟ࡃ࠸⑕≧࡜ࡑࡢࢣ࢔.⚄⤒㞴⑓⦆࿴ࢣ࢔ web ㅮ₇఍ 2023.03.22࠙ᣍᚅㅮ₇ࠚ

4.

ཎཱྀ 㐨Ꮚ. 㞴⑓ࡢࢣ࢔࣐ࢿࢪ࣓ࣥࢺ㸫ᨭ᥼ࡢ≉ᚩ࡜ᒎ㛤㸫, ᶓ὾ᕷ㞴⑓ᝈ⪅ᨭ᥼ࢣ࢔࣐
ࢿࢪ࣮ࣕ◊ಟ, 2023. 3.16࠙ᣍᚅㅮ₇ࠚ

5.

୰ᒣ ඃᏘ.

ࢸࣞࢼ࣮ࢩࣥࢢࡢᐇ㊶᪉ἲ㸬᪥ᮏᅾᏯࢣ࢔Ꮫ఍࢖ࣀ࣮࣋ࢩࣙࣥ◊ಟ఍,2022࢜ࣥࢹ࣐ࣥࢻ◊ಟ఍࠙ᣍᚅㅮ₇ࠚ
6.

୰ᒣ ඃᏘ. ⥔ᣢ࣭Ᏻᐃᮇࡢ┳ㆤ㹼㌟య≧ἣࡀᏳᐃࡋࠊ㞴⑓࡜࡜ࡶ࡟ඹᏑࡋࠊ⮬ศࡽࡋ࠸⏕άࢆ㏦ࡿࡓࡵࡢᨭ᥼㹼.⚄⤒⑓㝔┳ㆤ◊ಟࢪ࢙ࢿࣛࣝࢥ࣮ࢫ,2023.1.25

7.

୰ᒣ ඃᏘ. ࣃࢿࣜࢫࢺ᪥⤒೺ᗣࢭ࣑ࢼ࣮21ࠕࡇࢀ࠿ࡽࡢ ALS ἞⒪࡜ࢣ࢔ࠖ2023.1.16

8.

ཎཱྀ 㐨Ꮚ. 㐍⾜ᮇ࣭ពᛮỴᐃᨭ᥼ࡢ┳ㆤ, ᮾி㒔❧⚄⤒⑓㝔⚄⤒㞴⑓┳ㆤ◊ಟ,2022.12.16.

9.

୰ᒣ ඃᏘ , ᯈᇉ ࡺࡳ 㸪ཎཱྀ 㐨Ꮚ㸪ᯇ⏣ ༓᫓㸪ᑠ಴ ᮁᏊ. 㞴⑓┳ㆤࡢຠᯝⓗ⥅⥆௓ධ㹼㞴⑓┳ㆤᖌࡢά⏝࡟ࡼࡿ㞴⑓ᨭ᥼ࡢ㉁ྥୖࢆ┠ᣦࡋ࡚㹼ཌ⏕ປാ┬㞴἞ᛶ⑌ᝈඞ᭹
ᨻ⟇◊✲,㞴⑓ᝈ⪅࡬ࡢ⥲ྜⓗᨭ᥼యไ࡟㛵ࡍࡿ◊✲, ⌜఍㆟, 2022.12.10web 㛤ദ

10. ୰ᒣ ඃᏘ. ࠙┳ㆤᐇ㊶ղࠚ㸲㸬⏕άሙ㠃࣭≧ἣูᨭ᥼, ➨ 10 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ, 2022.12 web ㅮ⩏
11. ཎཱྀ 㐨Ꮚ. 㞴⑓ไᗘࡢ⌧≧, ➨ 10 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ,2022.12 web ㅮ⩏
12. ୰ᒣ ඃᏘ㸬඲ᅜ㞴⑓ᝈ⪅⏕άᐇែㄪᰝ࠿ࡽぢ࠼ࡿ㞴⑓ᝈ⪅ࡢከᵝ࡞ࢽ࣮ࢬ࡜ᨭ᥼࡟㝿ࡋ
࡚ࡢどⅬ㸬2022 ᖺ㞴⑓ᨭ᥼Ꮫ⾡ࢥࣥࢯ࣮ࢩ࢔࣒ྜྠ఍㆟͆㞴⑓ࡢᣑࡀࡾ࡜ᑓ㛛ᛶࡢ㏣
ồ͇,2022.12.1web
13. ୰ᒣ ඃᏘ.ࠕALS ᝈ⪅ࡀ⮬ศࡽࡋࡃ⏕ࡁ࡚࠸ࡃࡓࡵ࡟㹼ࡘ࡞ࡀࡾࢆ኱ษ࡟ࠊ⒪㣴⏕άࢆㆤࡿ㹼ࠖ.௧࿴㸲ᖺᗘ➨㸯ᅇරᗜ┴㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᨭ᥼༠㆟఍⚄⤒㞴⑓㒊఍◊ಟ఍.2022.11.26.රᗜ┴࠙ᣍᚅㅮ₇ࠚ
14. ཎཱྀ 㐨Ꮚ. 㞴⑓┳ㆤ஦౛᳨ウ ⚄⤒㞴⑓ゼၥ┳ㆤࡢ┳ㆤ㐣⛬, ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳－1－ㆤᖌ➼㣴ᡂ◊ಟ ᗙᏛ◊ಟϩ㸦web), 2022.11.1-12.13.
15. ୰ᒣ ඃᏘ. ⚄⤒㞴⑓⒪㣴⪅࡟࠾ࡅࡿẼ㐨ࢣ࢔࡜ᅾᏯ⏝་⒪ᶵჾࡢᏳ඲⟶⌮, ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟᛂ⏝ࢥ࣮ࢫ, 2022.11
16. ᯇ⏣ ༓᫓㸬ቚ⏣༊ಖ೺ᡤ(ᮾி㒔)

web ㅮ⩏◊ಟ఍ㅮᖌ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅⅏ᐖ᫬ಶูᨭ᥼ィ⏬◊ಟ

2022.11

17. ᯇ⏣ ༓᫓㸬ᮾி㒔❧ከᦶ❧ᕝಖ೺ᡤ ◊ಟ఍ㅮᖌ ᅾᏯேᕤ࿧྾ჾ⿦╔㞴⑓ᝈ⪅ࡢ⅏ᐖᑐ⟇㹼ከ⫋✀㐃ᦠ࡛ྲྀࡾ⤌ࡴᖹᖖ᫬࠿ࡽࡢഛ࠼㹼(ᮾி㒔)

2022.1118. ୰ᒣ ඃᏘ. 㞴⑓ᝈ⪅ࡢ⌮ゎ࡜ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ,2022 ᖺᗘᒣ᲍┴ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐ࢿ
࣮ࢪ࣮ࣕ㣴ᡂ◊ಟ఍,2022.11.1,㸦ᒣ᲍┴┳ㆤ༠఍,㸧
19. ཎཱྀ 㐨Ꮚ. 㞴⑓ᝈ⪅ࡢ⌮ゎ࡜ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ, 2022 ᖺᗘᒣ᲍┴ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐ࢿ
࣮ࢪ࣮ࣕ㣴ᡂ◊ಟ఍,2022.11.1,㸦ᒣ᲍┴┳ㆤ༠఍㸧
20. ᑠ಴ ᮁᏊ. ୰㔝༊ಖ೺ᡤ࣭㞴⑓ಖ೺ᖌ◊ಟ 㸦୰㔝༊㸧2022.10.27
21. ᑠ಴ ᮁᏊ㸬ᒸᒣᐙ᪘┳ㆤ◊✲఍ 㞴⑓⒪㣴ࢆᨭ࠼ࡿ᪋⟇࡜⚄⤒㞴⑓ࡢ≉ᛶ࣭ᨭ᥼࡟㝿ࡋ࡚␃ពࡋࡓ࠸ࡇ࡜

(web 㛤ദ) 2022.10.22 ࠙ᣍᚅㅮ₇ࠚ

22. ᯇ⏣ ༓᫓㸬ಙᕞ኱Ꮫ ࢤࢫࢺㅮᖌ

㞴⑓┳ㆤࡢᐇ㊶ࡸ◊✲άື(㛗㔝┴) 2022.10

23. ᯇ⏣ ༓᫓㸬බ┈♫ᅋἲேᮾி㒔┳ㆤ༠఍ࢼ࣮ࢫࣉࣛࢨ ゼၥ┳ㆤᖌ⫱ᡂᇶᮏࢥ࣮ࢫࡢ◊ಟㅮᖌ ALS࣭ࣃ࣮࢟ࣥࢯࣥ⑓ᝈ⪅ࡢ┳ㆤ㸦ᮾி㒔㸧2022.10

24. ᯇ⏣ ༓᫓㸬බ┈♫ᅋἲேᮾி㒔┳ㆤ༠఍ࢼ࣮ࢫࣉࣛࢨ ゼၥ┳ㆤᖌ⫱ᡂᇶᮏࢥ࣮ࢫࡢ◊ಟㅮᖌࠕᅾᏯ࡛ࡢேᕤ࿧྾ჾ⿦╔⒪㣴⪅ࡢ┳ㆤ (ᮾி㒔)

2022.1025. ୰ᒣ ඃᏘ. ᅜ❧⑓㝔ᶵᵓ௧࿴㸲ᖺᗘࠕ⚄⤒࣭➽⑌ᝈࠖᨻ⟇་⒪ࢿࢵࢺ࣮࣡ࢡ༠㆟఍୰ᅜᅄᅜࣈࣟࢵࢡ◊ಟ఍ 2022.10.20web ࠙ᣍᚅㅮ₇ࠚ
26. ᯇ⏣ ༓᫓㸬᪂ᐟ༊ಖ೺ᡤ

ㅮ₇఍ㅮᖌ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖࡢഛ࠼㹼ࢥࣟࢼ⚝࡛⪃࠼ࡿࡇ࡜㹼(ᮾி㒔) 2022.10
27. ᯇ⏣ ༓᫓㸬ᮾி㒔すከᦶಖ೺ᡤ ◊ಟ఍ㅮᖌ ALS ࢆ୰ᚰ࡜ࡋࡓ࿧྾㞀ᐖ࡜ᄟୗ㞀ᐖࡢᨭ᥼ࡢ࣏࢖ࣥࢺ(ᮾி㒔)

2022.928. ᯇ⏣ ༓᫓㸬ᮾி㒔❧⚄⤒⑓㝔 ◊ಟ఍ㅮᖌ ࿧྾ࢣ࢔࡟ࡘ࠸࡚▱ࢁ࠺ ᅾᏯ࡛ࡼࡃ࠶ࡿ
ࢺࣛࣈࣝ࡜ほᐹࡢ࣏࢖ࣥࢺ

ேᕤ࿧྾ჾ⿦╔⪅ࡢ┳ㆤ(ᮾி㒔)

2022.929. ཎཱྀ 㐨Ꮚ. ၻ⑱྾ᘬ➼ㄆᐃ≉ᐃ⾜Ⅽᴗົࡢไᗘ, ᅾᏯ་⒪Ᏻ඲. 㒔་Ꮫ◊ኟࡢࢭ࣑ࢼ࣮
㞴⑓ࡢᆅᇦࢣ࢔ࢥ࣮ࢫ, 2022.7-9.26 web ㅮ⩏－1 5－

30. ᯇ⏣ ༓᫓㸬ᯈᶫ༊ಖ೺ᡤ

◊ಟ఍ㅮᖌ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ಶูᨭ᥼ィ⏬సᡂ࡟క࠺་⒪ᶵჾࡢ㟁※⟶⌮(ᮾி㒔)

2022.831. ᯇ⏣ ༓᫓㸬ᮾி㒔༡ከᦶಖ೺ᡤ ◊ಟ఍ㅮᖌ ᮾி㒔ᅾᏯேᕤ࿧྾ჾ౑⏝⪅⅏ᐖ᫬ಶูᨭ᥼ᣦ㔪ࢆά⏝ࡋࡓಶูᨭ᥼ィ⏬⟇ᐃ࡜ᨭ᥼࡟ࡘ࠸࡚(ᮾி㒔)

2022.732. ᯇ⏣ ༓᫓㸬㟼ᒸ♫఍೺ᗣ་Ꮫ኱Ꮫ㝔 ࢤࢫࢺㅮᖌ 㞴⑓┳ㆤࡢᐇ㊶ࡸ◊✲άື(㟼ᒸ┴)
2022.7
33. ᯇ⏣ ༓᫓. ᮾி㒔ከᦶ❧ᕝಖ೺ᡤ◊ಟ఍ㅮᖌ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢᨭ᥼ࡢ࣏࢖ࣥ

ࢺ(ᮾி㒔) 2022.7
34. ୰ᒣ ඃᏘ. ⚄⤒㞴⑓⒪㣴⪅ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥᨭ᥼, ௧࿴ 4 ᖺᗘ ᅾᏯேᕤ࿧྾ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟ, ᇶ♏ࢥ࣮ࢫ, eb ㅮ⩏, 2022.6
35. ཎཱྀ 㐨Ꮚ. ᅾᏯேᕤ࿧྾⟶⌮࡟࠾ࡅࡿࣄࣖࣜࣁࢵࢺ, ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟ ᗙᏛ◊ಟϨ㸦web), 2022.6.24-8.30.
36. ཎཱྀ 㐨Ꮚ. 㞴⑓ࡢゼၥ┳ㆤ. ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟ ᗙᏛ◊ಟϨ㸦web), 2022.6.24-8.30.
37. ᯇ⏣ ༓᫓㸬බ┈♫ᅋἲேᮾி㒔┳ㆤ༠఍ࢼ࣮ࢫࣉࣛࢨ ◊ಟㅮᖌ⿦╔⒪㣴⪅ࡢ┳ㆤ(ᮾி㒔)
38. ᯇ⏣ ༓᫓㸬༡ከᦶಖ೺ᡤ
ᡂ࡟ࡘ࠸࡚(ᮾி㒔)ᅾᏯ࡛ࡢேᕤ࿧྾ჾ

2022.6◊ಟ఍ㅮᖌ ಖ೺ᖌࡢ⅏ᐖ᫬άືࡢᇶᮏ࡜ಶูᨭ᥼ィ⏬ࡢస

2022.639. ᯇ⏣ ༓᫓㸬ᮾி㒔ከᦶᑠᖹಖ೺ᡤ

◊ಟ఍ㅮᖌ ⅏ᐖ᫬ಶูᨭ᥼ィ⏬࡟ࡘ࠸࡚(ᮾி㒔)

2022.640. ཎཱྀ 㐨Ꮚ. ㉁ⓗ◊✲, ᮾி㒔❧⚄⤒⑓㝔┳ㆤ◊✲ᣦᑟ, 2022.5.31.
41. ཎཱྀ 㐨Ꮚ. ࢡࣜࢸ࢕࣮ࢡ, ᮾி㒔❧⚄⤒⑓㝔┳ㆤ◊✲ᣦᑟ, 2022.5.20.

IV. ≉グ஦㡯<Ꮫ఍άື>1.

୰ᒣ ඃᏘ ᪥ᮏ⚄⤒Ꮫ఍➽ⴎ⦰ᛶഃ⣴◳໬⑕(ALS)デ⒪࢞࢖ࢻࣛ࢖ࣥసᡂጤဨ

2.

୰ᒣ ඃᏘ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍⌮஦

3.

୰ᒣ ඃᏘ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ┳ㆤᖌㄆᐃጤဨ఍/ᩍ⫱◊ಟጤဨ/ᰝㄞጤဨ

4.

୰ᒣ ඃᏘ ➨ 27 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍௻⏬ጤဨ(ᴗົᇳ⾜⌮஦)

－1 6－

5.

୰ᒣ ඃᏘ ➨ 5 ᅇ᪥ᮏᅾᏯ་⒪㐃ྜᏛ఍Ꮫ⾡኱఍๪኱఍㛗6.

୰ᒣ ඃᏘ ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ఍⌮஦

7.

୰ᒣ ඃᏘ ୍♫)ᅾᏯࢣ࢔Ꮫ఍ᅾᏯࢣ࢔࢖ࣀ࣮࣋ࢩࣙࣥ◊✲࣭◊ಟጤဨ఍ጤဨ

8.

୰ᒣ ඃᏘ ᕝᓮ࿧྾ࢣ࢔ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ◊✲఍ୡヰே

9.

ཎཱྀ 㐨Ꮚ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍⌮஦ (⥲ົᢸᙜ⌮஦)

10. ཎཱྀ 㐨Ꮚ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍ ㄆᐃ 㞴⑓┳ㆤᖌㄆᐃጤဨ/ᰝㄞጤဨ
11. ཎཱྀ 㐨Ꮚ ୍♫㸧᪥ᮏᅾᏯ┳ㆤᏛ఍ ⦅㞟ጤဨ12. ᯇ⏣ ༓᫓ ᪥ᮏ⚄⤒Ꮫ఍➽ⴎ⦰ᛶഃ⣴◳໬⑕(ALS)デ⒪࢞࢖ࢻࣛ࢖ࣥసᡂ◊✲༠ຊ⪅
13. ᯇ⏣ ༓᫓ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍ ᩍ⫱◊ಟጤဨ఍ጤဨ
14. ᯇ⏣ ༓᫓ ᪥ᮏ⚄⤒➽ᦤ㣗ᄟୗ࣭ᰤ㣴Ꮫ⾡㞟఍ᮾி኱఍ࠊ๪஦ົᒁ㛗15. ᯇ⏣ ༓᫓ ➨ 27 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ ௻⏬ጤဨ
16. ᑠ಴ ᮁᏊ ୍♫㸧᪥ᮏ㞴⑓┳ㆤᏛ఍⌮஦ ⥲ົᢸᙜ⌮஦<♫఍άື࣭ጤဨ>17. ୰ᒣ ඃᏘ ᮾி㒔㞀ᐖ⪅᪋⟇᥎㐍༠㆟఍ᑓ㛛ጤဨ18. ୰ᒣ ඃᏘ ᮾி㒔㞀ᐖᇶ♏ㄪᰝጤဨ19. ୰ᒣ ඃᏘ ᮾி㒔≉Ṧ⑌⑓ᑐ⟇༠㆟఍ᅾᏯ⒪㣴࣭་⒪㐃ᦠᨭ᥼ᑐ⟇㒊఍ጤဨ
20. ୰ᒣ ඃᏘ ᮾி㒔㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ጤဨ
21. ୰ᒣ ඃᏘ ᪥ᮏ ALS ༠఍ࠕᆅᇦ㛫᱁ᕪ࡟㛵ࡍࡿ◊✲఍ࠖጤဨ22. ୰ᒣ ඃᏘ ᅾᏯேᕤ࿧྾ჾ࡟㛵ࡍࡿㅮ⩦఍ጤဨ఍ጤဨ
23. ཎཱྀ 㐨Ꮚ ௓ㆤ⚟♴ኈᅜᐙヨ㦂ጤဨ
24. ᑠ಴ ᮁᏊ 㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ጤဨ㸦⏫⏣ᕷⴱ㣭༊ከᦶᑠᖹಖ೺ᡤすከᦶಖ೺ᡤ㸧25. ᑠ಴ ᮁᏊ 㞴⑓᝟ሗࢭࣥࢱ࣮஦ᴗ㸦㞴⑓་Ꮫ◊✲㈈ᅋ㸧 㐠Ⴀጤဨ
26. ᑠ಴ ᮁᏊ 㞴⑓┦ㄯᨭ᥼ࢭࣥࢱ࣮㛫ࡢࢿࢵࢺ࣮࣡ࢡ஦ᴗ௻⏬㐠Ⴀ㒊఍ 㒊఍ဨ
27. ᑠ಴ ᮁᏊ ඵ⋤Ꮚᕷ㞴⑓ಖ೺་⒪⚟♴ㄪᩚ఍㆟ ጤဨ<ᩍ⫱άື>
28. ୰ᒣ ඃᏘ ᮾி་⛉ṑ⛉኱Ꮫ/ᖇி⛉Ꮫ኱Ꮫ 㠀ᖖ໅ㅮᖌ－1 7－

29. ᑠ಴ ᮁᏊ ᮾி་⛉ṑ⛉኱Ꮫ/Ⲉᇛ࢟ࣜࢫࢺᩍ኱Ꮫ/Ṋⶶ㔝኱Ꮫ㠀ᖖ໅ㅮᖌ30. ᯈᇉ ࡺࡳ ᮾி㒔❧኱Ꮫ㠀ᖖ໅ㅮᖌ－1－ࣉࣟࢪ࢙ࢡࢺྡ

I.

ᇶ┙ᢏ⾡ᨭ᥼ࢭࣥࢱ࣮࣭ື≀ᐇ㦂㛤Ⓨᐊㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Yasuda SP, Miyasaka Y, Hou, Obara Y, Shitara H, Seki Y, Matsuoka K, Takahashi A,

akai E,

Hibino H, Takada T, Shiroishi T, Kominami R, Kikkawa Y. (2022) Two Loci Contribute to AgeRelated Hearing Loss Resistance in the Japanese

ild-Derived Inbred MSM/Ms Mice. doi:

10.3390/biomedicines10092221 Biomedicines 10(9):2221
2.

Miwatashi, Ishida M, Takashino A, Kobayashi K, Yamaguchi M, Shitara H, Koike S. (2022)

Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice. doi:10.1128/jvi.00561-22 J
Virol 96(15):e0056122
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧࡞ࡋIV. ≉グ஦㡯

－1－

㸦ィ 0 ௳㸧ࣉࣟࢪ࢙ࢡࢺྡ

I.

ᇶ┙ᢏ⾡ᨭ᥼ࢭࣥࢱ࣮࣭◊✲ᢏ⾡㛤Ⓨᐊㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Kashii H, Kasai S, Sato A, Hagino Y, Nishito Y, Kobayashi T, Hino O, Mizuguchi M, Ikeda K.
(2023) Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mousemodel of tuberous sclerosis complex. Hum Genomics. 2023 Feb 2 17(1):4. doi: 10.1186/s40246023-00450-2.

2.

Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y,
Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi
N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y,
Murakami M. (2023) Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8
supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell Rep. 2023
Jan 30 42(2):111940. doi: 10.1016/j.celrep.2022.111940.

3.

Ryosuke Ishimura, Afnan H El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko
Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol LeeOkada, Tarek M Mohamed, Takehiko Yokomizo, Takashi Ueno, Kenji Sakimura, Tohru
Natsume, Hiroyuki Sorimachi, Toshifumi Inada, Satoshi

aguri, Nobuo N Noda, Masaaki

Komatsu. (2022) The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat
Commun. 2022 Dec 21 13(1):7857. doi: 10.1038/s41467-022-35501-0.
4.

Tsujihana K, Tanegashima K, Santo Y, Yamada H, Akazawa S, Nakao R, Tominaga K, Saito R,
Nishito Y, Hata RI, Nakamura T, Murai I, Kono Y, Sugawa M, Tanioka M, Egawa G, Doi M, Isa T,
Kabashima K, Hara T, Okamura H. (2022) Circadian protection against bacterial skin infection by
epidermal C CL14-mediated innate immunity. Proc Natl Acad Sci U S A. 2022 Jun
21 119(25):e2116027119. doi: 10.1073/pnas.2116027119. Epub 2022 Jun 15.

5.

Liang L, Takamiya R, Miki Y, Heike K, Taketomi Y, Sugimoto N, Yamaguchi M, Shitara H,
Nishito Y, Kobayashi T, Hirabayashi T, Murakami M. (2022) Group IVE cytosolic phospholipase
A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.
FASEB J. 2022 May 36(5):e22301. doi: 10.1096/fj.202101958R.

－1

－

6.

Akiyoshi Matsugi, Satoru Nishishita, Naoki Yoshida, Hiroaki Tanaka, Shinya Douchi, Kyota
Bando, Kengo Tsujimoto, Takeru Honda, Yutaka Kikuchi, Yuto Shimizu, Masato Odagaki, Hideki
Nakano, Yohei Okada, Nobuhiko Mori, Koichi Hosomi, Youichi Saitoh. Impact of Repetitive
Transcranial Magnetic Stimulation to the Cerebellum on Performance of a Ballistic Targeting
Movement. The Cerebellum., B 20220704. (doi.org/10.1007/s12311-022-01438-9)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 5 ௳㸧⮬⏤ᥖ㍕
1.

኱ෆྐᏊࠊᅵ஭ዉ✑Ꮚࠊ୕ୖᜤᖹࠊ஭ཱྀ⩏ಙࠊ㐍⸨┿⏤⨾ࠊ⛙຾ᚿࠊᑠ㔝ᘺᏊᖏᆺ➽ࢪࢫࢺࣟࣇ࢕࣮㹐㸯ᆺࣔࢹ࣐ࣝ࢘ࢫࡢ⫢⮚࡟࠾ࡅࡿ⬡㉁⵳✚ᢚไ ➨⫥ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ྡྂᒇ 2022/11/9-112.

ྂ⏣ᓥᾈᏊࠊⴗཎⱥ㞝ࠊబ⸨ᩔᚿࠊⴗ㔝ὒᏊࠊ⏣୰⨾Ṍࠊຍ⸨႐ஂࠊす⸨Ὀᫀࠊ㧗ᯇᖾ㞝ࠊෆ㔝ⱱኵࠊᐑᕝ๛ࠊụ⏣࿴㝯 (2022) GABAA ཷᐜయ࢔ࣥࢱࢦࢽࢫࢺࡢࣆࢡࣟࢺ࢟ࢩࣥᭀ
㟢࡟ࡼࡿ௘ࡢ⮬㛢⑕ᵝ⾜ື࡜㑇ఏᏊⓎ⌧ゎᯒ,

BPCNPNPPP4 Ꮫ఍ྜྠᖺ఍, 㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ, ி㒔 2022/11/4
3.

OBA Masaki, SHINDO Mayumi, FUKUI Koji, SANGO Kazunori, SU UKI Mari (2022) Agerelated changes in Rubicon post-translational modifications in Drosophila. 45 ᅇ᪥ᮏᇶ♏⪁໬Ꮫ఍኱఍ி㒔 2022/7/27-28

4.

Kotajima-Murakami H, Hagihara H, Sato A, Hagino Y, Tanaka M, Katoh Y, Nishito Y, Takamatsu
Y, Uchino S, Miyakawa T, Ikeda K (2022) Exposure to GABAA receptor antagonist picrotoxin in
pregnant mice causes autism-like behaviors and aberrant gene expression in offspring.
NEURO2022. Ἀ⦖>@5.

Motomi Matsuno, Tomoyuki Miyashita, Kotaro Konno, Kyohei Mikami, Junjiro Horiuchi,
Masahikoatanabe, Minoru Saitoe. ͆Localization of dopamine receptors and dopamine transporterin adult Drosophila brain.͇ ➨ 45 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍

2022 ᖺ 7 ᭶ 2 ᪥－1 1－Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧࡞ࡋIV. ≉グ஦㡯－1－ࣉࣟࢪ࢙ࢡࢺྡ

I.

ᇶ┙ᢏ⾡ᨭ᥼ࢭࣥࢱ࣮

ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1. Akiyoshi Matsugi, Satoru Nishishita, Naoki Yoshida, Hiroaki Tanaka, Shinya Douchi, Kyota Bando,
Kengo Tsujimoto, Takeru Honda, Yutaka Kikuchi, Yuto Shimizu, Masato Odagaki, Hideki Nakano,
Yohei Okada, Nobuhiko Mori, Koichi Hosomi, Youichi Saitoh. Impact of Repetitive Transcranial
Magnetic Stimulation to the Cerebellum on Performance of a Ballistic Targeting Movement. The
Cerebellum., B 20220704. (doi.org/10.1007/s12311-022-01438-9)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼㸦ィ 0 ௳㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ ௳㸧ࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
1.

Motomi Matsuno, Tomoyuki Miyashita, Kotaro Konno, Kyohei Mikami, Junjiro Horiuchi,
Masahikoatanabe, Minoru Saitoe. Localization of dopamine receptors and dopamine transporterin adult Drosophila brain. ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍

 ᖺ  ᭶  ᪥III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧࡞ࡋIV. ≉グ஦㡯－1－Ἀ⦖ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮

ࣉࣟࢪ࢙ࢡࢺྡ

I.

⑓㝔➼㐃ᦠᨭ᥼ࢭࣥࢱ࣮࣭ศᏊ⑓⌮࣭ࣄࢫࢺࣟࢪ࣮ゎᯒᐊㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 8 ௳㸧
1.

Miho Uematsu, Kyohei Mikami, Ayako Nakamura, Ryosuke Takahashi, Takanori Yokota, Katsuiku
Hirokawa, Toshiki Uchihara. Parallel gold enhancement of quantum dots 565/655 for doublelabelling correlative light and electron microscopy on human autopsied samples. Scientific Reports.
2022 Apr 12 12(1): 6113.

2.

Seki E, Komori T, Arai N. Distribution of amyloid-ȕprecursor protein-immunoreactive axons differs
according to the severity of cerebral ischemia in autopsy brains. Neuropathology. 2022 Aug 42(4): 269-273. doi: 10.1111/neup.12809.

3.

Hiroaki Ishida, Mitsuhiro Miyashita, Kenichi Oshima, Ito Kawakami, Kazunari Sekiyama, Mai
Kounoe, Erika Seki, Nobutaka Arai, Shunya Takizawa, Eiichiro Nagata, Masanari Itokawa, Makoto
Arai. Carbonyl stress-sensitive brain regions in the patient with treatment-resistant schizophrenia
with a glyoxalase 1 frameshift mutation: Autopsy study. Psychiatry Research Case Reports. 2022
Dec 100064.

4.

Katoh Y, Iriyama T, Yano E, Sayama S, Seyama T, Kotajima-Murakami H, Sato A, Sakuma H, Iguchi
Y, Yoshikawa M, Inaoka N, Ichinose M, Toshimitsu M, Sone K, Kumasawa K, Nagamatsu T, Ikeda
K, Osuga Y. Increased production of inflammatory cytokines and activation of microglia in the fetal
brain of preeclamptic mice induced by angiotensin II. J Reprod Immunol. 2022 Dec 154: 103752.

5.

Yonenobu Y, Beck G, Kido K, Maeda N, Yamashita R, Inoue K, Saito Y, Hasegawa M, Ito H,
Hasegawa K, Morii E, Iwaki T, Murayama S, Mochizuki H. Neuropathology of spinocerebellar
ataxia type 8: Common features and unique tauopathy. Neuropathology. 2023 Jan 26. doi:
10.1111/neup.12894.

6.

Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y,
Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi N,
Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y,
Murakami M. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies
endogenous choline to replenish the methionine cycle with methyl groups. Cell Rep. 2023 Jan 30
42(2):111940. doi: 10.1016/j.celrep.2022.111940.

－1

－

7.

Seki E, Komori T, Arai N. Expanded ischemic lesion due to herniation leads to axonal injury in asite remote to the primary lesion on autopsy brain with acute focal cerebral ischemia.
Neuropathology. 2023 Feb 28. doi: 10.1111/neup.12900.

8.

Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM,
Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM,
Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG,
Leverenz JB, Latimer CS, Mackenzie IR, Mao, McAleese KE, Merrick R, Montine TJ, Murray

ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye
KE, Teich AF, Thal DR, Tom SO, Troncoso JC,

ang SJ,

hite CL 3rd,isniewski T, Yang HS,

Schneider JA, Dickson D , Neumann M. LATE-NC staging in routine neuropathologic diagnosis:
an update. Acta Neuropathol. 2023 Feb 145(2):159-173.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼
1.

㸦5 ௳㸧

㛵⤮㔛㤶 ୰ᯡ⚄⤒⣔ࡢᰁⰍἲ࡜⤌⧊ᡤぢ ➨  ᅇ ᪥ᮏ⚄⤒⑓⌮Ꮫ఍⚄⤒⑓⌮ࢥ࢔࣒࢝ࣜ࢟ࣗࣛᩍ⫱ࢭ࣑ࢼ࣮ࣁࣥࢻ࢔࢘ࢺ➨  ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍㸸 ᖺ  ᭶2.

㛵⤮㔛㤶࣐࣍ࣝࣜࣥᅛᐃ࣭ࣃࣛࣇ࢕ࣥษ∦㸯㸧ᅛᐃ㸦㸵㸧୰ᯡ⚄⤒⣔ࡀࢇࢤࣀ᳨࣒
ᰝࡢ᳨యࡢྲྀࡾᢅ࠸0HGLFDO 7HFKQRORJ\  ᖺ  ᭶

3.

㛗㇂ᕝᡂேࢡࣛ࢖࢜㟁㢧ࡀゎࡁ᫂࠿ࡍ⚄⤒ኚᛶ⑌ᝈࡢ࣓࢝ࢽࢬ࣒௻⏬ࠊ⦅㞟ࠊᕳ㢌ࡢࡇ࡜ࡤ་Ꮫࡢ࠶ࡺࡳ  ᖺ᭶

4.

ᶡ㇂ឡ⌮ࠊ㛗㇂ᕝᡂே ࢱ࢘⥺⥔ᵓ㐀࡟ᇶ࡙࠸ࡓࢱ࢘࢜ࣃࢳ࣮ࡢ⑌ᝈศ㢮 ་Ꮫࡢ࠶ࡺ
ࡳ  ᖺ᭶

5.

㛗㇂ᕝᡂே $/6 ᝈ⪅⬻࡟⵳✚ࡍࡿ 7'3 ⥺⥔ࡢᵓ㐀 ་Ꮫࡢ࠶ࡺࡳ    ᖺ  ᭶

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 7 ௳㸧1.

㛵⤮㔛㤶. ୰ᯡ⚄⤒⣔ࡢᰁⰍἲ࡜⤌⧊ᡤぢ. ➨ 17 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍⚄⤒⑓⌮ࢥ࢔࣒࢝ࣜ࢟ࣗࣛᩍ⫱ࢭ࣑ࢼ࣮. 2022 ᖺ 6 ᭶ 27 ᪥̽7 ᭶ 29 ᪥. (࢜ࣥࢹ࣐ࣥࢻ)2.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶࡢཎᅉ࡜࡞ࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢ⏕໬Ꮫࠊᵓ㐀ゎᯒ. Movement
Disorders Conference. 2023 ᖺ 3 ᭶ 30 ᪥ (࢜ࣥࣛ࢖ࣥ㛤ദ)

3.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែᙧᡂ࡜㐍⾜ᶵᗎ. ➨ 242 ᅇ⏕࿨⛉Ꮫࣇ࢛࣮࣒ࣛ. ᪥ᮏグ⪅ࢡࣛࣈ. 2023 ᖺ 3 ᭶ 29 ᪥.

－1 5－

4.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟࠾ࡅࡿ⑓ⓗࢱࣥࣃࢡ㉁ࡢ⵳✚࡜ఏ᧛. ௧࿴ 4 ᖺᗘ ᪥ᮏ⚄⤒Ꮫ఍஑ᕞᆅ༊⏕ᾭᩍ⫱ㅮ₇఍. 2023 ᖺ 3 ᭶ 26 ᪥. (࢜ࣥࣛ࢖ࣥ㛤ദ)

5.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ⬻࡟⵳✚ࡍࡿ⣽⬊ෆ␗ᖖࢱࣥࣃࢡ㉁⥺⥔ࡢᵓ㐀ゎᯒ.
Parkinson s Disease Meet the Expert in Miyagi. 2023 ᖺ 2 ᭶ 8 ᪥. (࢜ࣥࣛ࢖ࣥ㛤ദ)

6.

㛗㇂ᕝᡂே. ⚄⤒ኚᛶ⑌ᝈ࡟⵳✚ࡍࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢ⏕໬Ꮫࠊᵓ㐀ゎᯒ. Nano tech2023 ➨ 22 ᅇᅜ㝿ࢼࣀࢸࢡࣀࣟࢪ࣮⥲ྜᒎ࣭ᢏ⾡఍㆟. ᮾிࣅࢵࢡࢧ࢖ࢺ. 2023 ᖺ 2 ᭶
3 ᪥.

7.

㛗㇂ᕝᡂே. ALS ᝈ⪅⬻࡟⵳✚ࡍࡿ TDP-43 ⥺⥔ࡢᵓ㐀ゎᯒ. ➨ 6 ᅇ ࡏࡾ࠿ᇶ㔠 ཷ㈹ᘧ. ᮾி. 2022 ᖺ 12 ᭶ 16 ᪥. (ࣁ࢖ࣈࣜࢵࢻ㛤ദ)ࡑࡢ௚ 㸦ィ 10 ௳㸧⮬⏤ᥖ㍕
1.

ᯘ೺ኴ㑻, 㛵⤮㔛㤶, ᑠᓥ฼㤶. ➽ⴎ⦰ᛶഃ⣴◳໬⑕ࡢ⑓⌮ࢹ࣮ࢱ࣮࣋ࢫࡢᵓ⠏ ᖺᗘ㒔❧⑓㝔➼㐃ᦠ◊✲Ⓨ⾲఍2022/6/2 ᮾி 2.

㛵⤮㔛㤶, ᑠ᳃㝯ྖ, ᪂஭ಙ㝯. ȕ-Amyloid precursor protein ච␿⤌⧊໬ᏛᰁⰍ᳨࡛ฟࡉࢀࡿ

⬻⹫⾑࡟ࡼࡿ㍈⣴㞀ᐖࡢศᕸࡣ⬻⹫⾑ࡢ㔜⑕ᗘࢆ཯ᫎࡍࡿ. ➨ 63 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍,2022/6/25 (ி㒔).
3.

ᑠᓥ฼㤶, 㛵⤮㔛㤶, ᳜ᮌಙᏊ, ඵᮌ᭸Ꮚ, ᒣすᖖ⨾, ᪂஭ಙ㝯. ᮾி㒔་Ꮫ◊࣭⬻⚄⤒⑓⌮ࢹ࣮ࢱ࣮࣋ࢫ  ᖺḟሗ࿌. ➨  ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍, 2022/6/25 (ி㒔) .
4.

㛵⤮㔛㤶, ᑠᓥ฼㤶, ᳜ᮌಙᏊ, ඵᮌ᭸Ꮚ, ᪂஭ಙ㝯. ࢙࢘ࣈࢧ࢖ࢺࢆά⏝ࡋࡓ୰ᯡ⚄⤒⣔ᶆᮏస〇ࡢ᝟ሗⓎಙ-㉁ၥࢥ࣮ࢼ࣮ࡢ㛤タ. ➨ 63 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍, 2022/6/26 (ி㒔).
5.

ᑠᓥ฼㤶, 㛵⤮㔛㤶, ᪂஭ಙ㝯. ࣓ࢭࢼ࣑ࣥ㖟ᰁⰍἲࡢ᳨ウ. ➨ 63 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍,2022/6/26 (ி㒔).
6.

ᯘ೺ኴ㑻, 㛵⤮㔛㤶, ୰ᒣඃᏘ, ᑠᓥ฼㤶, ᯇ⏣༓᫓, ᮌ⏣⪔ኴ, ΎỈಇኵ, ᑠ᳃㝯ྖ, 㧗ᶫ୍ྖ. ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿ⮫ᗋ⤒㐣ࡢ㏿ࡉ࡜㐠ືࢽ࣮ࣗࣟࣥ௨እ࡬ࡢ⑓ኚᣑ኱ࡢ
㛵㐃. ➨ 63 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍, 2022/6/26 (ி㒔).
7. ᯘ೺ኴ㑻ᯇ⏣༓᫓㛵⤮㔛㤶୰ᒣඃᏘᑠᓥ฼㤶ᮌ⏣⪔ኴΎỈಇኵᑠ᳃㝯ྖ㧗ᶫ୍ྖ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿయ㔜ῶᑡ࡜⑓⌮Ꮫⓗ࡞⑓ኚᣑ኱ࡢ㛵㐃᪥ᮏ⚄⤒ᦤ㣗ᄟୗᰤ㣴Ꮫ఍, 2022/9/3 (ᮾி).
8. ▼⏣⿱᫛, ᐑୗගᘯ, ኱ᓥ೺୍, Ἑୖ⥴, 㛵ᒣ୍ᡂ, 㬨Ụ┿⥔, 㛵⤮㔛㤶, ᪂஭ಙ㝯, ℧⃝ಇஓ, Ọ⏣ᰤ୍㑻, ⣒ᕝᫀᡂ, ᪂஭ㄔ. ⤫ྜኻㄪ⑕ᝈ⪅Ṛᚋ⬻ࡢ኱⬻-ᇶᗏ᰾-ᑠ⬻࡟࠾ࡅࡿ࣌
ࣥࢺࢩࢪࣥ⵳✚. ➨ 44 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫᖺ఍, 2022/11/4 (ᮾி).
9. ኱ෆྐᏊ, ᅵ஭ዉ✑Ꮚ, ୕ୖᜤᖹ, ஭ཱྀ⩏ಙ, 㐍⸨┿⏤⨾, ⛙຾ᚿ, ᑠ㔝ᘺᏊ. ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕࣮㹐㸯ᆺࣔࢹ࣐ࣝ࢘ࢫࡢ⫢⮚࡟࠾ࡅࡿ⬡㉁⵳✚ᢚไ. ➨ 95 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍,2022/11/9ࠥ10 (ྡྂᒇ).

－1 6－

10.

▼⏣⿱᫛, ᐑୗගᘯ, ኱ᓥ೺୍, Ἑୖ⥴, 㛵ᒣ୍ᡂ, 㬨Ụ┿⥔, 㛵⤮㔛㤶, ᪂஭ಙ㝯, ℧⃝ಇஓ, Ọ⏣ᰤ୍㑻, ⣒ᕝᫀᡂ, ᪂஭ㄔ. ៏ᛶᮇ⤫ྜኻㄪ⑕ᝈ⪅ࡢṚᚋ⬻࡟࠾ࡅࡿ࣌ࣥࢺࢩࢪࣥ⵳✚. ➨ 17 ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍, 2023/3/25 (࢜ࣥࣛ࢖ࣥ㛤ദ).

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ ௳㸧࡞ࡋIV. ≉グ஦㡯

－1 7－ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤᖺሗ㸦2023 ᖺ∧㸧2023ᖺ᭶Ⓨ⾜⦅㞟࣭Ⓨ⾜බ┈㈈ᅋἲே ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ
ࠛ156-3100 ᮾி㒔ୡ⏣㇂༊ୖ໭ἑ 2-1-6㟁ヰ␒ྕ 03-5316-3100㸦௦⾲㸧
URL http://www.igakuken.or.jp/

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古紙配合率70％再生紙を使用しています