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ABSTRACTS

8.4 and 3.2 respectively. 30-day unscheduled readmission OR wereincreased with Ca/VTE (4.2), Ca (3.4) and VTE (1.9). Hospital lengthof stay incidence-rate ratio (IRR) were increased with Ca/VTE (4.9),
Ca (2.4) and VTE (4.5).
Conclusion: Cancer increases the risk of VTE which significantly
impacted on healthcare burden with increased mortality, length of
hospital stay and unscheduled readmission rates. Further studies on
VTE prophylaxis should be considered.
Disclosure of Interest: None declared.

PO505-TUE
A novel microfluidic device development for venous
thrombus understanding
Sugita N1, Hirakata H2, Inoue K3, Tatsumi K4, Koike K3 andMurai T1
1Psychiatry, Kyoto University/Japan; 2Anesthesiology, Kyoto
Medical Center; 3Primary Care and Emergency Medicine;4
Mechanical Engineering and Science, Kyoto University / Japan,
Kyoto City, Japan
Background: Pulmonary thromboembolism sometimes causes sudden
death. Prevention is hard for lacking mechanism understanding. There
are much fewer previous venous thrombus studies than arterial one.
Aims: Our aim is to extract physical elements of randomness andreproducibility of venous thrombus formation as convective reactiondiffusion system.
Methods: To meet our aim, we made a microfluidic device of silicone
rubber and a cover glass to visualize and quantify the thrombus formation with spatial, time and fluid field information. The inside wasfully siliconized and partly coated with collagen and temperature wascontrolled. Fluorescently-stained blood was flowed with venous shear
rate by a pressure control pumping device. We imaged the thrombus
formation by high-speed camera.
Results:
1 The length of collagen-coated part correlated with size of thrombus.
2 Temperature significantly influenced thrombus formation.
3 Temperature influenced the plasma viscosity much more thanhematocrit.
4 There were some reproducible patterns in the motion and the positional relation of fibrin, platelets, hemocytes and other elements.
5 Small fluorescent particles could be observed in fluid field.
Conclusion: Basically our element technologies of microfluidics can be
useful to quantify the thrombus formation with spatial, time and fluid
field information. It will be helpful for understanding the mechanismof venous thromboembolism as convective reaction-diffusion system.
Fluid field will be analyzed in particle image velocimetry by our imaging technology. To bring more physiological conditions, we have some
improvement plans such as lining the inside with endothelial cells,
designing another fluidic device of round-shaped cross section, and soon. Above technologies should be useful to develop a mathematicalmodel for calculating venous thrombogenesis in future. We made anovel microfluidic device to visualize and quantify the venous thrombus formation. It will be helpful for understanding the mechanism ofvenous thromboembolism.
Disclosure of Interest: None declared.

PO506-TUE
Anticoagulants for prevention of thrombotic
complications in patients on parenteral nutrition: asystematic review
Barco S1, Atema J2, Coppens M1, Serlie M3 and Middeldorp S1
1
Vascular Medicine; 2Surgery, Academic Medical Center;
3
Endocrinology and Metabolism, Academic Medical Centern,
Amsterdam, The Netherlands
Background: Patients on parenteral nutrition (PN) for intestinal failure
require central venous access, which is associated with the risk of catheter-related thrombosis (CRT) and pulmonary embolism (PE). Thereis poor consensus on CRT thromboprophylaxis, whilst comorbidities
often represent a contraindication for anticoagulants.
Aims: The aim of this review is to systematically evaluate the effect ofanticoagulation for CRT prevention in patients receiving PN.
Methods: We performed a systematic literature search. Intervention
and observational studies regarding either adult or pediatric patientson PN receiving anticoagulant regimens were included. Primary outcomes were: the rates of objectively confirmed CRT, PE, and major
bleeding events. Secondary outcomes were: prevalence, pharmacokinetics, and cost-effectiveness of anticoagulant agents, and rate of heparin-induced thrombocytopenia.
Results: We identified 1125 studies, of which 22 were included (7 intervention studies). None of the intervention studies showed an effect ofprophylactic unfractionated heparin for primary CRT prevention, while observational studies showed heterogeneous results. No
studies involved patients with acute CRT. Data regarding the rates ofother complications were scarce. The prevalence of anticoagulant
administration varied, ranging from 22 to 54% in studies publishedduring the past decade.
Conclusion: The administration of anticoagulants for CRT prevention
in patients on PN is not supported by evidence. Although anticoagulation is often prescribed, crucial gaps of knowledge regard efficacy andsafety of anticoagulants in this specific population, as well as theirpharmacokinetics and quality of treatment.
Disclosure of Interest: S. Barco: None declared, J. Atema: NoneDeclared, M. Coppens Grant/Research Support from: Boehringer Ingelheim and Sanquin Blood Supply, Consultant for: Boehringer Ingelheim, Daiichi Sankyo, the alliance of Bristol-Myers Squibb and Pfizer
and Sanquin Blood Supply, Speaker Bureau of: Boehringer Ingelheim,
Daiichi Sankyo, the alliance of Bristol-Myers Squibb and Pfizer andSanquin Blood Supply, M. Serlie Grant/Research Support from:TEFA Mediq, Consultant for: Fresenius, S. Middeldorp Grant/
Research Support from: Glaxo SmithKline, Aspen, Bristol-Meyers
Squibb/Pfizer and Sanquin Blood Supply, Consultant for: Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Daiichi-Sankyo.

PO507-TUE
Long-term parenteral nutrition-associatedthromboembolic and hemorrhagic complications in236 single-center outpatients
Barco S1, Coppens M1, Heuschen C1, Salman B1, Brekelmans M1,Serlie M2 and Middeldorp S1
1
Vascular Medicine, Academic Medical Center; 2Endocrinology
and Metabolism, Academic Medical Centern, Amsterdam, TheNetherlands
Background: Prevalence of home parenteral nutrition (PN) in Europe
is 1–13/million inhabitants. Although patients on PN require central
venous access and are often anticoagulated, little information is available regarding the rates of catheter-related thrombosis (CRT), pulmonaryembolism(PE),major
bleeding,
heparin-inducedthrombocytopenia (HIT), and vena cava syndrome (VCS).
© 2015 International Society on Thrombosis and Haemostasis 13 (Suppl. 2) (2015) 1–997