Uptdated on 15 November 2016
Program for Stensen 4

On 29th November, evening, Welcome Pizza at Ciro in Toyohashi.
Overseas participants. Meeting at new Grand Hotel at 17.00
Start from Higashi-Okazaki at 17.35 by Meitetsu train and Toyohashi at 18.03 by
JR train and taxi from Futakawa to Ciro.
Returning taxi direct to Toyohashi Stn.
The first day (30th November 2016)
Opening
9.00-9.10 Masataka Murakami (Okazaki): Development of salivological view throughthe Stensen symposia for 20 years.
Session I. From Basic Research to Clinical Application.
9.10-9.45 Andy Wolff (Tel-Aviv): Medication-induced salivary gland dysfunction.
9.45-10.20 Jörgen Ekström (Göteborg): Experimental studies on secretory effects ofsome atypical antipsychotics with special reference to the clozapine-inducedsialorrhea.
10.20-10.40 Coffee Break
10.40-11.15 Shmuel Muallem (Bethesda): Sjögren’s syndrome and autoimmune
pancreatitis: Fixing the duct fixes the acini.
11.15-11.50 Min Goo Lee (Seoul): Bicarbonate permeation through anion channels.
11.50-13.10 Lunch
Session II. Protein secretion
13.10-13.45 Massimo Castagnola (Rome): The application of mass spectrometry to thestudy of the intact human salivary proteome.
13.45-14.20 Junko Fujita-Yoshigaki (Matsudo): Mechanism for selective transport ofsecretory proteins into secretory granules of parotid acinar cells.
14.20-14.45 Osamu Katsumata-Kato (Matsudo): The role of membrane microdomains
for granule maturation in the rat parotid gland. (also P-12)
14.45-15.15 Coffee break
Session III. Electrolyte and Fluid secretion
15.15-15.50 Martin Steward (Manchester): Computational modelling of epithelial ion
transport - is it worth the trouble?

15.50-16.25 Yoshiro Sohma (Tokyo): What two direct observation methods show us inmembrane transport physiology: CARS microscopy and high-speed AFM.
16.25-17.00 Tetsuji Nakamoto (Matsumoto): Analysis of electrolyte and water transport
by the ex vivo mouse submandibular gland perfusion technique in geneticallymodified mice.
18.00-20.30 Dinner
The second day: on 1st December 2016
Session IV. Purinergic Signals
9.00-9.35 Ivana Novak (Copenhagen): Purinergic signaling in pancreas in health anddisease.
9.35-10.10 Kishio Furuya (Nagoya): Real-time imaging of ATP release induced byalveolar inflation in the rat lung ex-vivo.
Session V. Regeneration of salivary gland.
10.10-10.35

ToruHayashi(Sagamihara):Dynamics

of5-methylcytosine

and5-hydroxymethylcitosine in fetal submandibular gland development. (also P-11)
10.35-11.10 Matthew Hoffman (Bethesda): Fibroblast Growth Factor Receptor function
in salivary gland progenitor populations during development.
11.10-11.25 Coffee Break
11.25-11.50 Tetsuya Akamatsu (Tokushuma): Sexual difference in the regeneration
model of the rat submandibular gland. (also P-15)
11.50-12.25 Yuichi Kadoya (Sagamihara): Basement membrane dynamics in developing
salivary gland. (also P-10)
12.25-13.25 lunch
Session VI. Posters
13.25-14.55 10-min talks on the posters P1-P9.
P-1. Rei Nakao (Fujisawa): PKCε regulates MEK/ERK signaling pathway infibroblasts.
P-2. Chenjuan Yao (Tokushima): Induced expression of a subtilisin-like proprotein
PACE4 in the regulation model of rat submandibular gland.
P-3. Makoto Yamaguchi (Nagoya): Simulation of intracellular pH change caused by
NH4+ and AcO- pulses in pancreatic duct cell.
P-4. Yoshinori Sahara (Morioka) V-ATPase a3 subunit KO mouse shows decreasedsalivation.

P-5. Yoshiyuki Shibukawa (Tokyo) The expression patterns of clock genes in rat
submandibular acinar and ductal cells.
P-6. Muxin Wei (Nanjing) Effects of Chinese herb HQ on salivary fluid secretion byisolated and perfused rat submandibular glands.
P-7. Sadamitsu Hashimoto (Tokyo): Visualization of microcirculation and paracellularpathway in the perfused submandibular gland.
P-8. Akihiko Nezu (Tobetsu): Simultaneous monitoring of Ca 2+ response and salivary
secretion reveals the threshold level of intracellular Ca 2+ concentration for salivary
secretion in rat submandibular gland.
P-9. Takao Morita (Tobetsu): Enhancement of salivary secretions and gene expressions
in the submandibular gland and the brain by preadministration of pilocarpine.

The following posters are also displayed.
P-10. Yuichi Kadoya (Sagamihara): Basement membrane dynamics in developing
salivary gland.
P-11.

Toru

Hayashi(Sagamihara):

Dynamicsof5-methylcytosineand5-hydroxymethylcitosine in fetal submandibular gland development.
P-12. Osamu Katsumata-Kato (Matsudo): The role of membrane microdomains for
granule maturation in the rat parotid gland.
P-13. Sandra Derouiche (Okazaki): Functional interaction between TRPV4 andTMEM16A/ to stimulated saliva and tear secretion.
P-14. Keitaro Satoh (Mizuho): Involvement of MARCKS phosphorylation andtranslocation in amylase release in exocrine gland acinar cells.
P-15, Tetsuya Akamatsu (Tokushuma): Sexual difference in the regeneration model ofthe rat submandibular gland.
14.55-16.00 Poster viewing session
16.00-17.00 Kyogen “Fukuroh” (Owl)
17.30-20.00 DinnerThe third day: on 2nd December (afternoon: moving to Tokyo)
Session VII. Calcium hometostasis and further linkage to secretion
9.00-9.40 Indu Ambudkar (Bethesda): Plasma membrane Ca2+ entry in regulation ofsalivary gland function and dysfunction.
9.40-10.20 James W. Putney (Research Triangle Park): Physiological functions ofstore-operated calcium channels in exocrine glands.
10.20-10.40 Coffee Break
10.40-11.05 Sandra Derouiche (Okazaki): Functional interaction between TRPV4 andTMEM16A/ to stimulated saliva and tear secretion. (also P-13)
11.05-11.30 Keitaro Satoh (Mizuho): Involvement of MARCKS phosphorylation andtranslocation in amylase release in exocrine gland acinar cells. (also P-14)
11.30-12.00 Hiroshi Sugiya (Fujisawa) NF-κB regulates MEK/ERK signaling pathway
in fibroblasts.
12.00-13.30 lunch
Session VIII. How to break a bottleneck13.30-14.10 Akihiko Tanimura (Tobetsu): Roles of muscarinic receptors on the functionsof salivary glands.
14.10-14.35 Masataka Murakami (Okazaki) Microcirculation and paracellular fluid
secretion in the isolated perfused submandibular gland of rat.
14.35-14.40 Closing by Masanori Kashimata.
Farewell to Domestic Participants.

For Overseas participants after Stensen 4 on 2nd December.
15.30 After finishing check-out, we will go to Higashi-Okazaki station.
16.17 Departure from Higashi Okazaki
16.47 Change to Shinkansen “Hikari” to Tokyo at Toyohashi
18.10 arrival at Tokyo(You may send your luggage on Thursday from Okazaki New Grand Hotel to The Keio
Presso Inn Ohtemachi in Tokyo)

20.00-22.00 Dinner at Genkai-Fugu in Kanda