The 23rd TMIMS International Symposium on"New Frontiers in Ubiquitin Proteasome System"
December 6 (Tue), 2022
Tokyo Metropolitan Institute of Medical Science
Tokyo Metropolitan Institute of Medical Science (TMIMS) holds a series of the "TMIMS International
Symposium" on various subjects in medical and life science fields. The 23rd TMIMS International
Symposium takes place as a satellite meeting of the "Ubiquitin New Frontier ~ from Neo-Biology toTargeted Protein Degradation ~" held on December 3-4 at Ito Hall, the University of Tokyo. First of all,
we are very grateful to the invited speakers for attending consecutive conferences and visiting ourinstitute. As ubiquitin research is expanding in all areas of life science and medical research, many
researchers in TMIMS are very interested in the fundamental molecular mechanisms of ubiquitin
proteasome system and ubiquitin-related disease such as cancer, diabetes, neurodegenerative
disease, and neurodevelopmental disorders. In this symposium, prominent international scientists,
TMIMS researchers, and young researchers from the nearby universities gather and present the latest
findings and ideas on new molecular mechanisms of ubiquitin codes, proteasome, and developing
therapeutics.
I would like to thank TMIMS and the Grant-in-Aid for Scientific Research in Innovative Areas "Newfrontiers for ubiquitin biology driven by chemo-technologies", for supporting this symposium.
I hope that all participants, including young scientists and graduate students, enjoy high-quality
science and fruitful discussion!

Sincerely,
Yasushi Saeki, Ph.D.
Project Leader
Protein Metabolism Project
Tokyo Metropolitan Institute of Medical ScienceE-mail: saeki-ys@igakuken.or.jp

1General Information
Organizer
Yasushi Saeki (Tokyo Metropolitan Institute of Medical Science, Japan)
Sponsors
Tokyo Metropolitan Institute of Medical Science
Grant-in-Aid for Scientific Research on Innovative Areas ”New frontier for ubiquitin biology driven bychemo-technologies" from MEXT, JapanThe Uehara Memorial Foundation
Infection prevention measures
Participants are asked to wear masks. Please refrain from coming to the meeting if you have any of thesymptoms such as a fever of 37.5°C or higher, cough, sore throat, fatigue, or loss of taste or smell.
Registration
The registration desk will be open at the entrance hall from 9:00 a.m. on December 6.
Please pick up an abstract book and a name folder (please write your name).
Instructions for speakers
Presentations are expected to use his/her own laptop. The screen is optimized for 16:9 aspect (4:3 is alsofine). Only HDMI connector is available. If your computer is not equipped with HDMI, please bring anappropriate converter. For the speakers and chairpersons, lunch (Kamameshi) and buffet-style dinner will
be provided.
Venue
Auditorium, Tokyo Metropolitan Institute of Medical Science(Address: 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 Japan)

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Access to TMIMS~8-min walk from "Kamikitazawa" station of Keio-Line
Please note that ONLY local trains stop at "Kamikitazawa" station.

More information of TMIMS
Our institute aims to improve the medical treatment and welfare of citizens in Tokyo throughcomprehensive and integrative approaches to medical problems the big city is facing. We attempt toachieve the goals listed in the “Tokyo in Ten Years” plan which includes such projects as development of
diagnostic methods for early detection and assessment of cancer, improvement of the health caremeasures for elderly people and patients with incurable diseases, and accelerated clinical application ofresearch results. We will collaborate with municipal hospitals to develop new and better diagnostic
methods and also new drugs and therapeutic strategies.

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Program
9:00-10:00

Registration

10:00-10:10

Opening Remarks - Hisao Masai (The Director General of TMIMS)

10:10-11:50

Session 1 "Ubiquitin codes"
Chair: Fumiaki Ohtake (Hoshi University)

10:10-10:35

David Komander (Ubiquitin Signalling Division, WEHI, Australia)"Crossing Codes"

10:35-10:50

Jun-ichi Sakamaki (The University of Tokyo)"Ubiquitination of phosphatidylethanolamine in organellar membranes"

10:50-11:05

Yukiko Yoshida (Protein Metabolism Project, TMIMS)"Negative regulation of Nrf1 by noncanonical ubiquitination in NGLY1 deficiency"

11:05-11:20

Hiroyuki Sasanuma (Genome Project, TMIMS)"A role of UBC13-dependent ubiquitin signaling in the repair of blocking adducts from DNA
double-strand breaks"

11:20-11:35

Keijun Kakihara (Tokyo Institute of Technology)"Cis-activity regulation of USP8 and STAMBPL1, two endosomal deubiquitinating enzymes,and role of dysregulation in disease onset"

11:35-11:50

Shoji Hata (Calpain Project, TMIMS)"Identification of a novel ubiquitin-directed protease, CAPN15, as a regulator of E-cadherin"

11:50-13:00

Lunch

13:00-14:20

Session 2 "Proteasome structure and regulation"
Chair: Jun Hamazaki (The University of Tokyo)

13:00-13:25

Eri Sakata (Göttingen University, Germany)"Structural basis for regulation of the AAA+ ATPases in protein quality control"

13:25-13:40

Shoshiro Hirayama (The University of Tokyo)"The ESCRT-I complex mediates proteasomal degradation via PTPN23"

13:40-14:05

Kylie Walters (National Cancer Institute, USA)
"Interactions and Targeting of Proteasome Substrate Receptors hRpn10 and hRpn13"

14:05-14:20

Akinori Endo (Protein Metabolism Project, TMIMS)"Phase transition of ubiquitylated proteins triggered by ATP depletion"

14:20-14:40

Coffee Break

14:40-16:10

Session 3 "Protein quality control system"
Chair: Koji Yamano (TMDU)

14:40-15:05

Claudio Joazeiro (ZMBH, Heidelberg University, Germany)"Evolution of mechanisms for sensing and responding to ribosome stalling and collision"4

15:05-15:30

Hiroyuki Kawahara (Tokyo Metropolitan University)"Pre-emptive quality control machinery supports vesicular trafficking by ubiquitinating GDPbound Rab-family small GTPases"

15:30-15:55

Hsueh-Chi Sherry Yen (Institute of Molecular Biology, Academia Sinica, Taiwan)"C-degron pathways guard the fidelity of proteome"

15:55-16:10

Takuya Tomita (Protein Metabolism Project, TMIMS)"A quality control system for maintaining protein complex integrity"

16:10-16:30

Coffee Break

16:30-17:50

Session 4 "Physiology, disease and drug development"
Chair: Yasushi Saeki (TMIMS)

16:30-16:55

Daniel Finley (Harvard Medical School, USA)
"Global remodeling of the proteome in terminal differentiation"

16:55-17:10

Genjiro Suzuki (Dementia Research Project, TMIMS)"α-synuclein strains that cause distinct pathologies differentially inhibit proteasome"

17:10-17:25

Mari Suzuki (Diabetic Neuropathy Project, TMIMS)"A Drosophila model of diabetic neuropathy reveals a crucial role of proteasome activity inthe glia"

17:25-17:50

Alessio Ciulli (University of Dundee, UK)"How PROTAC degraders work: design principles and drug development for challenging
cancer targets"

17:50-18:00

Closing Remarks - Keiji Tanaka (The Board Chairperson of TMIMS)

18:00-20:00

Group Photo / Reception Party (Room 2BC)

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