38th Annual Meeting of the Society for Actinomycetes Japan
Dates: September 10 (Tue) - 11 (Wed), 2024
Venue: Hitotsubashi Hall, National Center of Sciences Building

September 10th (Tue)

9:00

Venue Opened

9:30

Opening Remark

9:35

Oral presentations (O1〜O6)

O-1

Classification of “Streptomyces hyalinum” and diversity of members in
the genus Embleya○Hisayuki Komaki1, Akira Hosoyama1, Akane Kimura1, Natsuko Ichikawa1,
Yasuhiro Igarashi2, Tomohiko Tamura1

O-2(1NBRC, 2 Fac. Eng., Toyama Prefectural Univ.)
Molecular phylogeny and biosynthetic gene clusters○Hideyuki Muramatsu, Masayuki Igarashi(Lab. Microbiol., BIKAKEN)

O-3

Increase in isolation frequency of rare actinomycetes bywater-in-oil droplets (WODL) cultivation
Jo Saito1, Akihiro Nakamura2, Wataru Ogasawara2, ○Natsumi Saito3(1Dept. Adv. Eng., NIT, Tsuruoka College, 2Nagaoka Univ. of Tech.,
3O-4

Dept. Creative Eng., NIT Tsuruoka College)

Exploring indicators to distinguish soil particles suitable for the isolation of
new actinomycetes○Mizuki Abe1, Yuka Nakanishi2, AN CHIJUN2, Takeshi Hosaka1,2,3(1Grad. Sch. of Sci. and Technol., Shinshu Univ. 2Fac. of Agric., Shinshu Univ.
3

O-5

IBS-ICCER., Shinshu Univ.)

In situ secondary metabolites detection from actinomycetes colonies by
Raman spectroscopy○Shunnosuke Suwa1,2, Masahiro Ando2,3, Takuji Nakashima3,
Haruko Takeyama1,2,3,4(1Grad. Sch. Adv. Sci. Eng., Waseda Univ., 2CBBD-OIL, AIST-Waseda Univ.,
3

Res. Org. Nano Life Innov.,

4

Inst. Adv. Res. Biosyst. Dyn., Waseda Res. Inst. Sci. Eng., Waseda Univ.)

1

O-6

Search for antimalarial compounds from microbial broths
So-ichiro Kimura1, ○Yoshihiro Watanabe1,2, Rei Hokari1,2, Aki Isiyama1,2,
Yuta Kikuchi1,2, Hayama Tsutsumi1,2, Yuki Inahashi1,2, Masato Iwatsuki1,2(1 Grad. Sch. Infection Control Sci., Kitasato Univ.,2Ōmura Satoshi Memorial Inst., Kitasato Univ.)

10:45

Break (10 min)

10:55

Oral presentations（O7〜O12）

O-7

Exploring natural products from rare actinomycetes targeting Ffh protein○Shotaro Hoshino1, Emiko Nagai2, Hisayuki Komaki3, Shinta Ijichi1,
Hiroyasu Onaka1

O-8(1Dept. of Life Sci., Gakushuin Univ., 2AECM, 3NBRC)
Heterologous production of lanthipeptide using biosynthetic genes fromthe actinomycete Streptomyces durhamensis○Marino Tsugimoto, Shinya Kodani(Grad. Sch. Agr. Sci. Shizuoka Univ.)

O-9

Alanyl-tRNA

Synthetase-like

Enzyme-Catalyzed

AminoacylationinAscamycin Biosynthesis○Yu Zheng1, Naoko Morita1, Hiroshi Takagi1, Yumi Shiozaki-Sato1, Jun Ishikawa2,
Kazuo Shin-ya3, Shunji Takahashi1(1 RIKEN CSRS, 2 NIID, 3 AIST)
O-10

Characterization of a sulfur insertion enzyme in albomycin biosynthesis○Richiro Ushimaru1,2, Ziyang Zhang2, Takahiro Mori1, Hung-wen Liu2, Ikuro Abe1

O-11

(1Grad. Sch. Pharm. Sci., Univ. Tokyo, 2 Dept. Chem., Univ. Texas, Austin)
Characterization of Biosynthetic Gene Cluster Containing a Novel GTP
Cyclohydrolase○Akari Umezawa1, Takeshi Tsunoda2, Ippei Shintaku1, Yasushi Ogasawara2,
Tohru Dairi2

O-12(1 Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2 Grad. Sch. Eng., Hokkaido Univ.)
Biosynthetic study on a compound consisting of maleic anhydride andpolyketide skeleton○Reona Suzuki1, Hayama Tsutsumi1,3, Akihiro Ishii1, Ayano Komaki2,
Yuka Yamakawa2, Yoshihiro Watanabe1,3, Masato Iwatsuki1,3,
Tomoyasu Hirose1,3, Toshiaki Sunazuka1,3, Yuki Inahashi1,3(1Grad. Sch. Infection Cont. Sci., Kitasato Univ., 2Sch. Science. Kitasato Univ.,
3

12:05

Ōmura Inst. Kitasato Univ.)

Lunch

2

13:25The SAJ Plenary Meeting

13:55

Award Ceremony

14:20

Award Lecture〈SAJ Merit Award〉
Isolation and taxonomic studies of untapped actinomycetes
Atsuko Matsumoto（Institute of Microbial Chemistry）

15:00

Award Lectures〈Hamada Award〉
Chemoenzymatic synthesis of cyclic peptides using biosynthetic enzymes
derived from actinobacteria
Kenichi Matsuda（Faculty of Pharmaceutical Sciences, Hokkaido University)
Studies on amino acid biosynthesis to boot-up the secondary metabolism
for peptide natural products in Streptomyces bacteria
Fumihito Hasebe（Faculty of Bioscience and Biotechnology, Fukui Prefectural
University）

15:30

Break (10 min)

15:40

Invited Lecture
Leveraging the Actinobacterial Strain Collection and Genome Database at NPDC
for Natural Products and Drug Discovery
Ben Shen1,2,3 (1Department of Chemistry, 2Department of Molecular Medicine,and 3Natural Products Discovery Center, The Herbert Wertheim UF Scripps
Institute for Biomedical Innovation & Technology)

16:25

Break (10 min)

16:35

Poster Presentations (Odd number)

17:35

Break, Move to the banquet venue

18:00

Banquet（Gakushi Kaikan）

3

September 11th (Wed)
9:00

Venue Opened

9:15

Oral presentations (O13〜O18)

O-13

Analysis of unique degradation pathway for black pepper alkaloid in
actinomycetes○Pu Jian1, Takuto Kumano2, Mio Kimura3, Makoto Kurisaki3,
Yoshiteru Hashimoto2 and Michihiko Kobayashi2(1Degree Program in Life and Agricultural Sciences, University of Tsukuba,

O-14

2

MiCS, University of Tsukuba,

3

Graduate School of Life and Environmental Sciences, University of Tsukuba)

Functional analysis of the sporangium membrane protein SmpB in

Actinoplanes missouriensis○Takeaki Tezuka1,2, Satoshi Maeda1, Kyota Mitsuyama1, Yasuo Ohnishi1,2(1Grad. Sch. of Agric. and Life Sci., Univ. of Tokyo, 2CRIIM, Univ. of Tokyo)
O-15

Analysis of the production mechanism of heat shock metabolites (HSMs) in

Streptomyces sp. AY2○Yanagi Mori1, Sosuke Kataoka1, Shun Saito1, Yohei Katsuyama2,3,
Yasuo Ohnishi2, 3, Midori A. Arai1(1Grad. Sch. Sci. Tech., Keio Univ., 2 Grad. Sch. Of Agric. And Life Sci., and3

O-16

CRIIM, Utokyo)

Studies on Cs resistance enhancement of Streptomyces lividans TK24
○Yohei Iizaka1, Aoi Ino1, Ayana Shimizu1, Nagisa Zaizen1, Atsushi Fukumoto1,
Yojiro Anzai1(1Fac. Pharm. Sci. Toho Univ.)

O-17

Characterization of chaplins and rodlins for the rodlet formation and cellsurface hydrophobicity of Streptomyces spp.
○Nurul Syahirah Shamsol Anuar1, Noraiza Suhaimi1, Takeaki Tezuka1,2,
Kenshi Suzuki1, Naoki Sunagawa1, Yasuo Ohnishi1,2, Hirofumi Hara1,2(1 Grad. Sch. of Agric. And Life Sci., The Univ. of Tokyo,
2

O-18

CRIIM, The Univ. of Tokyo)

Discovery of virus-like nanoparticles facilitating sporogenic differentiationof Streptomyces davawensis JCM 4913 through organisation of multicellular
structures○Toshiki Nagakubo1,2, Tatsuya Nishiyama3, Tatsuya Yamamoto1,
Nobuhiko Nomura1,2,4, Masanori Toyofuku1,2(1Facul. Life and Environ. Sci., Univ. Tsukuba, 2MiCS, Univ. Tsukuba,
3

Biores. Sci., Nihon University, 4TARA Center, Univ. Tsukuba)4

10:25

Break (10 min)

10:35

Poster Presentations (Even number)

11:35

Lunch

12:55

Oral presentations (O19〜O24)

O-19

Copper inactivates DcsB by oxidizing Cys86, one of the metal ligands, to thesulfinic acid
○Kosuke Oda1, Kenji Komaguchi2, Yasuyuki Matoba1(1Faculty of pharmacy, Yasuda Womensʼs Univ.
2

O-20

Grad. Sch. Adv. Sci. Eng, Hiroshima Univ.)

Probing the potential of biarylitide P450 as biocatalyst with rational enzyme
design and substrate manipulation○Yongwei Zhao1, Maxine Treisman1, Mathias Hansen1, Laura Coe2,
James De Voss2, Julien Tailhades1, Max J. Cryle1(1 The Monash Biomedicine Discovery Institute, Monash University, Australia,
2

School of Chemistry and Molecular Biosciences, University of Queensland,

Australia.)
O-21

Enhancement of cell membrane permeability of peptides by PIECE method○Kohei Kaneda, Kaito Suzuki, Tomoya Ogura, Fumihito Hasebe,
Chitose Maruyama, and Yoshimitsu Hamano

O-22(Grad. Sch. Biosci. Biotec., Fukui Pref. Univ.)
Transcriptionally induced nucleoid-associated protein-like ccr1 incombined-culture serves as a global effector of Streptomyces secondary
metabolism○Shumpei Asamizu1,2, Yukun Lei2, Hiroyasu Onaka2,3(1EGBRC, Kobe Univ., 2Grad. Sch. Agric., Univ. of Tokyo,
3

Dept. Life Sci., Gakushuin Univ.)

O-23 Identification and analysis of an unprecedented thioesterase in aryl polyene
biosynthesis○Seiji Kawai1, Yohei Katsuyama1,2, Yasuo Ohnishi1,2(1 Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo, 2 CRIIM, The Univ. of Tokyo)
O-24 Machine learning-guided discovery of novel oxygen and PLP-dependent
enzymes○Tomohiro Noguchi1,2, Takayoshi Awakawa2, Yutaka Saito1(1 Graduate School of Frontier Engineering, Kitasato Univ., 2CSRS, RIKEN.)
14:05

Break (15 min)5

14:20Awarding Ceremony (Excellent Poster Award)

14:40

SAJ39th Annual Meeting Announcement

14:45

Closing Remarks

15:20

The Memorial Symposium for Prof. Teruhiko Beppu(Open to the public, Hitotsubashi Hall)

6

Poster Presentations
P-1

Taxonomic study of motile actinomycetes isolated from the campus of
Chulalongkorn University, Thailand○Gaku Machida1, Chompoonik Kanchanabanca2, Shinya Kodani 3,
Ryota Moriuchi 4, Moriyuki Hamada 5, Susumu Kokubo 1, Youji Nakagawa 1,
Hideki Yamamura1(1Fac. Life Environ. Sci,, Univ. Yamanashi,

P-22

Dept. Microbiol., Fac. Sci., Chulalongkorn Univ., 3Fac. Agric., Shizuoka Univ.

4

Shizuoka Inst., Shizuoka Univ., 5NITE-NBRC)

Search for actinomycetes in soils of Ogimi Village, Okinawa Prefecture○Yukitoshi Iha1,2,3, Hidehiro Yokoda2, Ryo Higa2, Yuko Murayama1,
Naoko Yasuda1, Shinya Ikematsu1,2(1 NIT, Okinawa College GEAR5.0., 2 NIT, Okinawa College, Course of B. E.,
3

P-3

University of the Ryukyus, Faculty of Medicine.)

Proposal of a novel species of the genus Actinoplanes isolated from soil
○Jiahao Zeng1, Yohei Iizaka1, Moriyuki Hamada2, Aya Iwai1, Riku Takeuchi1,
Atsushi Fukumoto1, Tomohiko Tamura2, Yojiro Anzai1(1 Fac. Pharm. Sci., Toho Univ., 2 NITE, NBRC.)

P-4

Proposal of two novel species of the genera Streptomyces andKitasatospora isolated from xylose-added soil
○Moriyuki Hamada1, Narumi Enomoto1, Mayuko Abe2, Takuto Nishikubo2,
Shigeto Otsuka2,3(NITE, NBRC1, Grad. Sch. Agric. Life Sci, Univ. Tokyo.2, CRIIM, Univ. Tokyo.3)
P-5

A selective isolation for rare actinomycetes utilizing goadsporin○Shinta Ijichi, Shotaro Hoshino, Hiroyasu Onaka(Dept. of Life Sci., Gakushuin Univ.)

P-6

Isolation of actinobacteria from seashore environments on Boso Peninsulaand proposal of a new species of the genus Herbiconiux○Tomoyo Takagi, Narumi Enomoto, Hanako Naito, Tomohiko Tamura,Moriyuki Hamada(NITE・NBRC)

P-7

Isolation of anti-Bacillus compound-producing actinomycetes fromhigh-salinity fermented fish gravy and its microbiological characterization○Sakura Nogimura1, Saki Takamori2, Takahiro Osada3, Sachiko Masaki1,
Kosuke Kita1, Ryosuke Unno1, Kenji Arakawa4, Morio Ishikawa1, Toshihiro Suzuki1(1 Grad. Sch. Dept. Ferment. Sci., Tokyo Univ. Agric., 2 Dept. Ferment. Sci.,
Tokyo Univ. Agric., 3Osada Shouten., 4Integ. Sci. life., Hiroshima Univ.)

7

P-8

Identification of soybean root endophytic core bacteria grown in different
environments○Onishi Yuki1,2, Nishikawa Yohei 2,3 , Kifushi Masako1,2, Hosokawa Masato1,2,3,4,
Matsumoto Atsuko3, Nakashima Takuji3, Anai Toyoaki5, Takeyama Haruko1,2,3,4(1Grad. Sch. Adv. Sci. Eng., Waseda Univ., 2CBBD-OIL, AIST-Waseda Univ.,
3

Res.Org. Nano Life Innov., Waseda Univ., 4Inst. Adv. Res. Biosyst. Dyn.,

Waseda Res. Inst. Sci. Eng., Waseda Univ., 5Fac. Agric., Kyushu Univ.)
P-9

Development of a method to detect actinomycetes producing secondary
metabolites○Akira Také1, Yoshihiko Sakaguchi2, Yuki Inahashi3,4, Kazuyoshi Gotoh5,
Shunji Hayashi1(1Sch. Med., Kitasato Univ., 2Pharm. Sci., Tokushima Bunri Univ.,
3

Grad. Sch. Infection Control Sci., Kitasato Univ., 4Ōmura Satoshi Mem. Inst.,

Kitasato Univ., 5 Grad. Sch. Health Sci., Okayama Univ.)
P-10 Complete genome sequence of Lentzea jejuensis JNUCC 0626, a promisingbacterium for natural product discovery○Kyung A Hyun1, Seung-Young Kim3, Kyung-Hwan Boo1, Won-Jae Chi4,
and Chang-Gu Hyun2(1Dept. Biotech. Coll. Appl. Life Sci. Jeju Univ., 2Dept. Beaut. Cosmetol.
Jeju Inside Agy. Cosmetic Science Ctr. Jeju Univ., 3Dept. Pharm. Eng. Biotech,
Sunmoon Univ., 4Gen. Res. Ass. Div. Nat. Inst. Bio. Res.)
P-11 Structural biology of the mutant ribosome from a secondary metabolismActivated strain of Streptomyces coelicolor A3(2)○Taiyo Kuramoto1, Atsushi Minami, Takehito Tanzawa2, Takeshi Hosaka3,
Tomohisa Kuzuyama 1,4, Tetsuhiro Ogawa 1,4(1GSALS, UTokyo, 2IPR, Osaka Univ.,
3

Grad. Sch. of Sci. and Technol., Shinshu Univ., 4CRIIM, UTokyo.)P-12 Functional analysis of cell wall-localized proteins involved in mycelial
growth and sporangium formation in Actinoplanes missouriensis○Zhuwen Tan1, Takeaki Tezuka1,2, Yasuo Ohnishi1,2(1Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo,
2

CRIIM, The Univ. of Tokyo)

P-13 A master regulator for the concentration-dependent effects of the antibiotic
lincomycin on Streptomyces coelicolor A3(2)○Tomoko Shibayama1, Keiichiro Mukai1, Takeshi Hosaka1,2(1Grad. Sch. of Sci. and Technol.., Shinshu Univ. 2IBS-ICCR, Shinshu Univ.)8

P-14 Analysis of high-copy plasmids from Streptomyces sp. and their application
to the light-inducible production system○Atsushi Takamatsu, Hideaki Takano(Grad. Sch. Bioresour. Sci., Nihon Univ.)
P-15 Properties of granaticin as an organocatalyst and granaticin binding protein○Tatsuya Nishiyama, Natsuki Ota, Yujin Hiraga, Kenji Ueda
(College of Bioresource Sciences, Nihon University)
P-16 Analysis of light induction mechanism through SigK-RskA regulatory system○Ryuya Kageyama, Hideaki Takano(Grad. Sch. Bioresour. Sci., Nihon Univ.)
P-17 Expression analysis of selenium-containing formate dehydrogenase from theactinomycete Streptomyces incarnatus○Zhao Xiaohui, Mao Kubo, Tadayoshi Kanao, Michiko Nemoto, Takashi Tamura(Grad. Sch. Env. Life Nau. Sci., Okayama Univ.)
P-18 Analysis of DNA methyltransferases involved in genome methylation
modifications in Streptomyces○Ryuta Noya, Hideaki Takano(Grad. Sch. Bioresour. Sci., Nihon Univ.)
P-19 A highly precise and fast Actinobacterial genome editing system using therare-cutting restriction endonuclease PacI
○Syunsuke Kabaya1, Nobuki Sakurai2, Tadao Oikawa1, Kazuya Yamanaka1(1Grad. Sch. Sci. Eng. Kansai Univ., 2 JNC Corp. Yokohama RC)
P-20 A study on the development of bioformulation using actinomycete isolates
antagonistic to white spot disease fungus.
○Shun Kusakabe¹, Susumu Kokubo¹, Hiroshi Nakagawa¹, Mitsuyoshi Soya²,
Tomoya Izumi², Masayuki Hayakawa³, Hideki Yamamura¹(¹Fac. Life Environ Sci., Univ. Yamanashi, ²Suzuken Kogyo Co., Ltd.,³Yamanashi Pref. Univ.)
P-21 Effects of acid or heat stress on nucleic acid antibiotic production andexpression of quality control genes in Streptomyces incarnatus○Mao Kubo, Haruka Yamagata, Yuriko Nakashima, Tadayoshi Kanao,
Michiko Nemoto, and Takashi Tamura(Grad. Sch. Env. Life Nat. Sci., Okayama Univ.)
P-22 Drug repurposing: The story of rifampicin○Ye-Jin Lee, Yang Xu, Xu-hui Liang, Hyeon-Mi Kim, Sung-Min Bae,
Chang-Gu Hyun
(Jeju Inside Agency and Cosmetic Science Center, Department of Chemistry and
Cosmetics, Jeju National University)9P-23 Feedback inhibition insensitive aspartate kinase PddD in the biosynthesis ofγ-poly-D-diaminobutyric acid: characterization and its application for the
DAP pathway reinforcement○Yoshiya Miyake1, Tadao Oikawa1, Kazuya Yamanaka1(1Grad. Sch. Sci. Eng., Kansai Univ.,)
P-24 The effects of low concentrations of rifampicin on the development of rpoB
mutations in Streptomyces lividans○Miran Hasegawa1, Kosuke Tanioka1, Takeshi Hosaka1,2(1Grad. Sch. Sci. Technol., Shinshu Univ., 2IBS-ICCER, Shinshu Univ.)
P-25 Functional analysis of genes involved in the pigment production inducedby combined-culture○Ayari Kuboki1, Yukun LEI2 , Shumpei Asaimizu2, 3, Shotaro Hoshino1,
Hiroyasu Onaka1, 2(1Dept. of Life Sci., Gakushuin Univ. 2 The Univ. of Tokyo, 3Kobe Univ. EGBRC)
P-26 In Streptomyces, pyrogallol-induced hyphal branching mechanism involving
Oxidative Stress○Saho Fukuhara 1, Manami Kato 2, Shumpei Asamizu 3, Shotaro Hoshino 1,
Hiroyasu Onaka 1(1Dept. Of Life Sci., Gakushuin Univ., 2The Univ. of Tokyo, 3Kobe Univ. EGBRC)
P-27 Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter
actinomycete Actinoplanes sp. MM794L-181F6.
○Yasuhiro Takehana1, Hideyuki Muramatsu1, Masaki Hatano1, Maya Umekita1,
Yuko Shibuya1, Chigusa Hayashi1, Tomoyuki Kimura3, Toshifumi Takeuchi2,
Ryuichi Sawa3, Masayuki Igarashi1(1Lab. Microbiol., BIKAKEN, 2Lab. Chem., BIKAKEN,
3

Lab. Mol. Struct. Anal., BIKAKEN)

P-28 Relationship between salt-induced compatible solute accumulation andsecondary metabolite biosynthesis in Nocardiopsis alba TUA-HK2GM
isolated from Japanese traditional fermented fish product○Ryota Taira1, Yu Komiyama1, Motoki Takahashi2, Takahiro Osada3,
Ryosuke Unno1, Morio Ishikawa1, Toshihiro Suzuki1(1 Grad. Sch. Dept. Ferment. Sci., Tokyo Univ. Agric.,2

Dept. Ferment. Sci., Tokyo Univ. Agric., 3 Osada Shouten)

P-29 Searching for Specific Inhibitor of Novel Peptide Epimerase (MurL)
Participating in Peptidoglycan Biosynthesis○Aika Ono1, Takeshi Tsunoda2, Nonaka Kenichi3,4, Inahashi Yuki3,4,
Yasushi Ogasawara2, Tohru Dairi2(1Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2Grad. Sch. Eng., Hokkaido Univ.,
3

Grad. Sch. Infection Cont. Sci., Kitasato Univ., 4Ōmura Inst., Kitasato Univ.)10

P-30 Analysis of kinanthraquinone biosynthesis○Katsuyuki Sakai, Yuzhu Zhao, Shunji Takahashi(RIKEN CSRS)
P-31 Biosynthetic investigation of azoxyalkene compounds using comparative
genome analysis○Kaito Fukumori1, Haruka Nagano1, Yu Tanaka1, Takuya Kishimoto2,
Hirofumi Kunitake2, Kenji Arakawa1, 2(1Grad. Sch. Integr. Sci. Life, Hiroshima Univ.,
2

Grad. Sch. Adv. Sci. Matt., Hiroshima Univ.)

P-32 Functional analysis of an unprecedented NRPS-like machinery that
assembles amino acid building blocks into two dimensions○Kosei Fukue1, Haruhiko Kamada2, Tadao Oikawa1, Kazuya Yamanaka1(1Grad. Sch. Sci. Eng., Kansai Univ.,2 National Institute of Biomedical Innovation)
P-33 Genome mining of natural products with a five-membered carbon ringproduced by actinomycetes○Genki Hibi1, Taro Shiraishi1,2, Tomohisa Kuzuyama1,2(1GSALS, UTokyo, 2CRIIM, UTokyo)
P-34 Biosynthesis of Antitumor Antibiotic Mitomycin○Yudai Takahashi1, Takeshi Tsunoda2, Tohru Dairi2, Yasushi Ogasawara2(1Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2 Grad. Sch. Eng., Hokkaido Univ.)
P-35 Construction of a highly caprazamycin-producing strain using the genome
amplification mechanism from the kanamycin-producing Streptomyces stain○Yoshimasa Ishizaki, Sayaka takahashi, Masaki Hatano, Maya Umekita,
Masayuki Igarashi(Lab. Microbiol., BIKAKEN)
P-36 New elasnin and neoantimycin derivatives from Streptomyces sp. RK18A0406 expressing Syo_1.56 SARP regulator○Islam A. Abdelhakim1, Yushi Futamura2, Yukihiro Asami3, Hideaki Hanaki3,
Naoko Kito1, Arisa Shibata4, Sachiko Masuda4, Atsuya Muranaka5,
Hiroyuki Koshino5, Ken Shirasu4, Hiroyuki Osada2, Jun Ishikawa6,and Shunji Takahashi1(1 Nat. Prod. Biosynth., RIKEN CSRS; 2 Chem. Res. Dev., RIKEN CSRS;
3Ōmura Satoshi Memorial Institute, Kitasato Univ;

4

Plant Immunity, RIKEN CSRS; 5 Mol. Struct. Charact., RIKEN CSRS; 6 NIID)

P-37 Secondary metabolite analysis with an unstudied genus Cryptosporangium○Md. Julkar Nime1, Desy W. Triningsih1, Noa Yoshizaki1, Hideki Yamamura2,
Masayuki Hayakawa3, Nobuyasu Matsuura4, Naoya Oku1, and Yasuhiro Igarashi1(1Toyama Pref. Univ., 2Yamanashi Univ., 3Yamanashi Pref. Univ.,
4

Okayama Univ. Sci)
11

P-38 Effect of Nocardia spp. growth at the liquid interface on the production of
secondary metabolites○Ryosuke Ito¹, Susumu Kokubo¹, Youji Nakagawa¹, Masayuki Hayakawa2,
Hideki Yamamura1(1Fac. Life Environ. Sci., Univ. Yamanashi, 2Yamanashi Pref. Univ.)
P-39 Biosynthetic Study of Cyclopropylglycine Containing Peptide○Yu Suto1, Takeshi Tsunoda2, Yasushi Ogasawara2(1Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2Grad. Sch. Eng., Hokkaido Univ.)
P-40 Functional elucidation of polyketide synthase KS domain○Hiromitsu Yamamoto1, Misaki Aso2, Takuma Konno2, 3, Konoa Suda2, 3,Satoshi Yuzawa1, 2(1Syst. Biol. Prog. Grad. Sch. Media & Governance, Keio Univ.,
2Inst. Adv. Biosci., Keio Univ., 3Tsuruoka Chuo H.S.)

P-41 Analysis of secondary metabolites produced by Streptomyces sp.
TUA-HK1GM isolated from Japanese traditional fermented fish product,in the presence of salt
○Sachiko Masaki1, Sho Ogaki2, Asahi Hirata2, Takahiro Osada3, Ryosuke Unno1,
Morio Ishikawa1, Kenji Arakawa2, Toshihiro Suzuki1(1 Grad. Sch. Dept. Ferment. Sci., Tokyo Univ. Agric.,2

Integ. Sci. life., Hiroshima Univ., 3 Osada Shouten)

P-42 Studies in the lysine biosynthesis during ε-poly-L-lysine production in

Streptomyces albulus○Daisuke Shimada, Chitose Maruyama, Yoshimitsu Hamano, Fumihito Hasebe(Grad. Sch. Biosci. Biotec., Fukui Pref. Univ.)
P-43 Genome mining of a biosynthetic gene cluster with ANS pathway genes
from Streptomyces yatensis NBRC 101000○Yoshiyuki Kawano1, Yohei Katsuyama1, 2, Yasuo Ohnishi1, 2(1 Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo,
2

CRIIM, The Univ. of Tokyo)

P-44 Functional analysis of α-ketoglutarate-dependent oxygenase catalyzing
L-methionine demethylation○Taku Mizutani1, Lyu Zhou1,2, Takayoshi Awakawa2, Ikuro Abe1
(1 The Univ. of Tokyo, 2RIKEN, CSRS)
P-45 The Effect of mutagenesis of the rpoB gene on H457 to increase sinefungin
production.
○Takashi Tamura1, Hiromu Hasegawa1 , Tadayoshi Kanao1, Michiko Nemoto1,
Michio Yamamoto2(1Grad. Sch. Env. Life Sci., Okayama Univ., 2Osaka University)12P-46 Biosynthesis of streptazone polyketides from Streptomyces○Kento Yamada1, Taichi Hiramatsu1, Yohei Katsuyama1,2, Yasuo Ohnishi1,2(1 Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo,
2

CRIIM, The Univ. of Tokyo)
P-47 Engineering of unprecedented dehydratase Agm6 to expand the substratespecificity○Hitoki Takizawa1, Taro Shiraishi1,2, Tomohisa Kuzuyama1,2(1GSALS, UTokyo, 2CRIIM, UTokyo)
P-48 Biosynthetic Studies on Lasso Peptide RES701-2 Containing
7-Hydroxytryptophan
Yuka Yamaya1, ○Takeshi Tsunoda2, Yu Nakashima3, Chitose Maruyama4,
Yoshimitsu Hamano4, Hiroyuki Morita3, Yasushi Ogasawara2, Tohru Dairi2(1Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2Grad. Sch. Eng., Hokkaido Univ.,
3Inst. of Nat. Med., Univ. of Toyama, 4Grad. Sch. Biosci. Biotec., Fukui Pref. Univ.)

P-49 Functional enhancement of antitumor polyketides based on computational
prediction○Mei Okano1, Natsumi Nishiura2, Rukman Muslimin2, Kiep Min Do3,
Hiroyuki Morita3, Ahmed T. Ayoub4, Kenji Arakawa1,2(1Grad. Sch. Integr. Sci. Life, Hiroshima Univ.,
2

Grad. Sch. AdSM, Hiroshima Univ., 3Toyama Univ., 4HToO Bioscience）

P-50 Isolation, structure determination, and analysis for thermotolerancepromoting mechanism of the heat shock metabolite (HSM) produced by

Streptomyces sp. HR41
○Sosuke Kataoka, Shun Saito, Midori A. Arai
(Grad. Sch. Sci. Tech., Keio Univ.)
P-51 Development of a high-precision DNA assembly method for long
biosynthetic gene clusters○Tomoki Takeda1,2, Misaki Aso1, Hiroko Ueda1, Shotaro Kato1,2, Satoshi Yuzawa1,2(1Inst. Adv. Biosci., Keio Univ.,
2

Syst. Biol. Prog. Grad. Sch. Media & Governance, Keio Univ.)

P-52 Extensive screening of secondary metabolites in Indonesian Actinomycetes○Sho Ogaki1, Rukman Muslimin1, Alimuddin Ali2, Kenji Arakawa1(1 Grad. Sch. Integr. Sci. Life, Hiroshima Univ., 2 Makassar State Univ.)
P-53 Study on the activation of secondary metabolite production in actinomycetesby nisin○Yuta Awano1, Kaho Anegawa1, Miho Nagayoshi2, Hayama Tsutsumi1,2,
Yuta Kikuchi1,2, Yuki Inahashi1,2(1Grad. Sch. Infection Cont. Sci., Kitasato Univ., 2 Ōmura Inst., Kitasato Univ.)13

P-54 Analysis of salt-dependent co-production mechanism of surugamide andanti-Saccharomyces compound in Streptomyces diastaticus strain
TUA-NKU25 isolated from Niijima Kusaya○Takuma Ikegami1, Miu Ueki1, Mio Taguchi1, Shigeru Kitani2, Kenichi Matsuda3,
Toshiyuki Wakimoto3, Ryosuke Unno1, Morio Ishikawa1, Kenji Arakawa4,and Toshihiro Suzuki1(1Grad. Sch. Dept. Ferment. Sci., Tokyo Univ. Agric.,2

Dept. Chem. Biol. Sci., Aoyama. Gakuin Univ.,

3

Grad. Sch. Pharm., Hokkaido Univ., 4Integ. Sci. life, Hiroshima Univ.)

P-55 Development of a chemical structure-based method for discovering secondary
metabolites of actinomycetes using LC-Raman○Takuma Kyotani1, Takuji Nakashima2, Masahiro Ando2,3, Haruko Takeyama1,2,3,4(1 Grad. Sch. Adv. Sci. Eng., Waseda Univ., 2 Res. Org. Nano Life Innov., Waseda Univ.,
3

CBBD-OIL, AIST-Waseda Univ.,

4Inst. Adv. Res. Biosyst. Dyn., Waseda Res. Inst. Sci. Eng., Waseda Univ.)
P-56 Study on a Novel Organocatalyst Produced by Actinomycetes Analysis○Runa Akiba, Tatsuya Kanbayashi, Kenji Ueda, Tatsuya Nishiyama(College of Bioresource Sci., Nihon Univ.)
P-57 Structural diversity of 2,3-disubstituted butenolide-type signaling molecule
SRB and its application for genome mining○Momoko Akimoto1, Asahi Hirata1, Hazuki Fujita2, Miho Sumiyoshi3,
Miyuki Otsuka4, Maki Matsuura4, Aiko Teshima1, Kenji Arakawa1(1Grad. Sch. Integr. Sci. Life, Hiroshima Univ., 2Facul. Engineer., Hiroshima Univ.,
3

Grad. Sch. AdSM, Hiroshima Univ., 4Coll. Agric., Tamagawa Univ.)

P-58 Phylogeny-guided Characterization of Bacterial Hydrazine Biosynthesis
Mediated by Cupin/methionyl tRNA Synthetase-like Enzymes○Yuto Nakahara, Kuga Arima, Atina Rizkiya Choirunnisa, Kenichi Matsuda,
Toshiyuki Wakimoto(Grad. Sch. Pharm. Sci., Hokkaido Univ.)
P-59 Biosynthetic study of ST analogue possessing O-acylpeptide side chain○Kanki Matsuda1, Shun Uchiyama1, Yasushi Ogasawara2, Junko Hashimoto3,
Fumihito Hasebe1, Kazuo Shin-ya4, Tohru Dairi2, Yoshimitsu Hamano1,
Chitose Maruyama1(1 Grad. Sch. Biosci. Biotec., Fukui Pref. Univ., 2Grad. Sch. Eng., Hokkaido Univ.,
3

JBIC, 4AIST)

P-60 Chemical investigation on unstudied actinomycete of the genus Gandjariella○Desy Wulan Triningsih1, Satsuki Kimachi1, Fitria Ningsih2,
Wellyzar Sjamsuridzal2, Yasuhiro Igarashi1(1 Toyama Pref. Univ., 2 Univ. of Indonesia)
14P-61 Heterologous production of lanthipeptide using biosynthetic genes ofactinomycete Microbispora rosea○Ryo Kobayashi, Shinya Kodani(Grad. Sch. Agr. Sci., Shizuoka Univ.)
P-62 First microbial production of the ornithine homopolymer via forced
expression of a genetically dormant synthetase gene○Haruto Shimizu1, Munenori Takehara2, Tadao Oikawa1, Kazuya Yamanaka1(1Grad. Sch. Sci. Eng., Kansai Univ.,2 Univ. of Shiga Prefecture)
P-63 Genome mining of novel natural products focusing on rare actinomycetes○Yuka Matsuura1, Hayama Tsutsumi2, Yuki Inahashi2, Yohei Katsuyama1, 3,
Yasuo Ohnishi1, 3(1 Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo,
2Ōmura Memorial Ins. and Grad. Sch. of Infection Control Sci., Kitasato Univ.,

3

CRIIM, The Univ. of Tokyo)

P-64 Reaction Mechanism of Novel Peptide Epimerase (MurL) Participatingin Peptidoglycan Biosynthesis○Masaki Horiuchi1, Yu Nakashima2, Takeshi Tsunoda3, Hiroyuki Morita2,
Yasushi Ogasawara3, Tohru Dairi3(1Grad. Sch. Chem. Sci. Eng., Hokkaido Univ., 2Inst. of Nat. Med., Univ. of Toyama,
3

Grad. Sch. Eng., Hokkaido Univ.)

P-65 Structure-function analysis of a novel sulfonamide synthase SbzM in thebiosynthesis of altemicidin○Yuhao Zhu1, Takahiro Mori1,2, Takayoshi Awakawa1,3, Ikuro Abe1,2(1 Grad. Sch. Pharm. Sci., The University of Tokyo, 2 CRIIM, The University of Tokyo,
3

RIKEN CSRS)
P-66 Isolation and cultivation of microorganisms responsive to light irradiation
Linon Kubo1, Sakurako Moroga1, Kunio Yanatori1, ○Rei Miyano2, 3(1Mita International High school, 2Science Communicator,
3

Kitasato Inst. Life Sci.)

P-67 Screening method for actinomycetes based on imaging techniques○Maho Hajime1, Rei Miyano2,3(1 MITA International high school, 2 Science communicator,
3

Kitasato Inst. Life Sci.)

15

P-68 Engineering of Cytochrome P450 for Synthesis of Novel Reveromycin
Derivatives○Ya Fen Yong1,2, Song Liu3, Katsuyuki Sakai1, Keisuke Fujiyama1, Hiroshi Takagi1,
Yushi Futamura4, Takeshi Shimizu4, Hiroyuki Osada4, Takeo Usui5,
Eugene Boon Beng Ong2, Shunji Takahashi1(1 Nat. Prod. Biosynth., RIKEN CSRS, 2 INFORMM, Univ. Sains Malaysia,
3

Sci. Cent. Future Foods, Jiangnan Univ., 4 Chem. Res. Dev., RIKEN CSRS,

5

Grad. Sch. Life and Environ. Sci., Univ. Tsukuba)
P-69 Construction of genome editing system of cellulosic thermophilic

S. thermodiastaticus K5 strain.
○Kenji Yamagishi, Masakazu Ike, Ken Tokuyasu(National Agricultural and Food Research Organization (NARO), Institute of Food
Research)
P-70 The Distinct Protein Secretome of Two Streptomyces lavendulae Strains○Yoko Fujita-Yamaguchi1, 2, Rose Sheila Atukunda3, Hideyuki Muramatsu4,
Masayuki Igarashi4, Daniel Roeth1, Markus Kalkum1(1Beckman Research Inst. of City of Hope, 2Juntendo University Grad. Sch. Med.,
3

Irell & Manella Grad. Sch. Biol. Sci., City of Hope, 4Inst. of Microbial Chemistry)P-71 Construction of genome analyzing tools for natural products discovery○Hayama Tsutsumi1,2, Yuta Kikuchi1,2, Yuki Inahashi1,2(1Grad. Sch. Infection Cont. Sci., Kitasato Univ., 2Ōmura Inst., Kitasato Univ.)
P-72 Cultivation of actinomycetes on solid media with sterilized humus○Kota Kobayashi1, Mizuki Abe1, Takeshi Hosaka1,2(1Grad. Sch. Sci. Technol., Shinshu Univ., 2IBS-ICCER, Shinshu Univ.)
P-73 Structure-activity relationship of goadsporin aiming for novel antibiotic○Chihiro Hoshino, Shotaro Hoshino, Hiroyasu Onaka(Dept. of Life Sci., Gakushuin Univ.)

16