⡿ᅜ䛾⢭⚄⑌ᝈศ㢮DSM-5 2013ᖺᨵᐃ

2022ᖺ12᭶13᪥ᩥ⛉┬䛾Ⓨ⾲ ඲Ꮫ❺䛾8.8%䛜Ⓨ㐩㞀ᐖ䛾ྍ⬟ᛶデ᩿ᇶ‽䛾ኚ໬䜔䚸ぶ䛜᪩ᮇ䛻་⪅䛻㐃䜜䛶⾜䛟䛣䛸䜒䚸Ⓨ㐩㞀ᐖቑຍ䛾୍ᅉ䛸
3䛺䛳䛶䛔䜛䛜䚸ᐇᩘ䜒ቑ䛘䛶䛔䜛䛸ከ䛟䛾ᑓ㛛ᐙ䛜ᣦ᦬䛧䛶䛔䜛䚹

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2012ᖺ䚸ᩥ⛉┬䛾ㄪᰝ䛷඲Ꮫ❺䛾6.5䠂䠄15ே䛻1ே䠅䛜Ⓨ㐩㞀ᐖ䛾ྍ⬟ᛶ䚹Ꮫ⩦㞀ᐖ䠄LD䠅䠖ㄞ䜏᭩䛝䚸⟬ᩘ䛰䛡䛖䜎䛟䛷䛝䛺䛔ὀពḞዴከືᛶ㞀ᐖ䠄ADHD䠅䠖ከືᛶ䚸⾪ືᛶ௚ே䛸䛾䝁䝭䝳䝙䜿䞊䝅䝵䞁䛜ⱞᡭ䚸ᖖྠ⾜ື䛺䛹䛾⑕≧䚹⮬㛢⑕䝇䝨䜽䝖䝷䝮㞀ᐖ䠄௨ୗ⮬㛢⑕䠅䠖

Ⓨ㐩㞀ᐖ䛾デ᩿ᇶ‽Ⓨ㐩㞀ᐖ䜔䛂ษ䜜䜔䛩䛔䛃䛂ᘬ䛝䛣䜒䜛䛃䛺䛹⬻䛾ാ䛝䛻㞀ᐖ䛾䛒䜛Ꮚ䛹䜒䛜ቑ䛘䛶䛔䜛䠍䠊ᅜෆ䛷ᛴቑ䛩䜛Ⓨ㐩㞀ᐖᮌᮧ䞊㯮⏣⣧Ꮚ䞊᪥ᖖ䛻䛒䜅䜜䜛⎔ቃ䝩䝹䝰䞁䜔⚄⤒᧠஘≀㉁䞊

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᭷ᐖ໬
໬Ꮫ≀㉁䛜

᭷ᐖ໬Ꮫ≀㉁䛛䜙Ꮚ䛹䜒䜢Ᏺ䜛䝛䝑䝖䝽䞊䜽タ❧㞟఍Ꮚ䛹䜒䛾⬻Ⓨ㐩䛻ཬ䜌䛩ᙳ㡪

2023ᖺ4᭶22᪥

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௧࿴4ᖺ7᭶12᪥ ᩥ㒊⛉Ꮫ┬㈨ᩱ䜘䜚᪥ᮏ䛻䛚䛡䜛Ⓨ㐩㞀ᐖᐖඣ䛾ቑຍຍຍ-≉ูᨭ᥼Ꮫ⣭䠆㈨ᩱ䜢㻿㻺㻿䛺䛹䛷౑⏝䛧䛯䛔ሙྜ䛿䚸ண䜑䛚▱䜙䛫䛟䛰䛥䛔䚹㒊ศⓗ䛻ษ䜚ྲྀ䛳䛯᝟ሗ䛿䚸ㄗゎ䜢ᣍ䛟䛣䛸䛜䛒䜛䛾䛷䛚㢪䛔䛧䜎䛩䚹㻣㻚 ᭷ᐖ໬Ꮫ≀㉁䛛䜙Ꮚ䛹䜒䜢Ᏺ䜛䛯䜑䛻㻢㻚 䝅䜾䝘䝹ẘᛶ䠎 ⚄⤒ఏ㐩⣔䜢᧠஘䛩䜛ẅ⹸๣䠄㎰⸆䠅㻡㻚 䝅䜾䝘䝹ẘᛶ䠍 ෆศἪ⣔䜢᧠஘䛩䜛⎔ቃ䝩䝹䝰䞁㻠㻚 Ⓨ㐩㞀ᐖ䛾せᅉ䛸䛺䜛᭷ᐖ໬Ꮫ≀㉁䛾✀㢮㻟㻚 ᪥ᮏே䛾໬Ꮫ≀㉁᭚㟢䛾ᐇែ㻞㻚 䝠䝖䛾⬻䛾Ⓨ㐩㻝㻚 Ⓨ㐩㞀ᐖ䛾ᛴቑ䛸䛭䛾ཎᅉ㻻㼁㼀㻸㻵㻺㻱

5㑇ఏᏊ䛿ኚ䛘䜙䜜䛺䛔䛜䚸⎔ቃせᅉ䛿ኚ䛘䜛䛣䛸䛜䛷䛝䜛䟿7䜋䛸䜣䛹䛾⑓Ẽ䜔⑌ᝈ䛻䛿㑇ఏᏊ䛜㛵ಀ䛩䜛䛜䚸⮬㛢⑕䛷䛿㐣኱ホ౯䛥䜜䛯䚹• 2011ᖺ ṇ☜䛺␿Ꮫㄪᰝ䛜ᐇ᪋䛥䜜䚸㑇ఏᛶ䛿⣙37䠂䛸ሗ࿌䛥䜜䛯䚹ṧ䜚䛾63䠂䛿⎔ቃせᅉ䚹Hallmayer et al. Arc Gen Psychiatry. 2011༢୍䛾ཎᅉ㑇ఏᏊ䛿ぢ䛴䛛䜙䛺䛛䛳䛯䛜䚸⌧ᅾ⣙1000䜒䛾⮬㛢⑕㛵㐃㑇ఏᏊ䛜ሗ࿌䚹䝅䝘䝥䝇䝅䝘䝥䝇ᙧᡂ䛻㛵㐃䛩䜛㑇ఏᏊ䛜ከ䛔䚹

• 1990ᖺ䛤䜝䡚 䛣䛾㑇ఏᛶ92䠂䛜㐣኱ホ౯䛥䜜䚸⮬㛢⑕䇾ཎᅉ䇿㑇ఏᏊ᥈⣴䛾◊✲➇த䛜ጞ䜎䛳䛯䚹• 1977ᖺ 䜲䜼䝸䝇䛾␿Ꮫㄽᩥ䛷䚸⮬㛢⑕䛿㑇ఏᛶ䛜92䠂䛸䛥䜜䛯䚹䠄䝷䝍䞊་ᖌ䠅
䛯䛳䛯21⤌䛾୍༸ᛶ཮⏕ඣ䛾ㄪᰝ䚸デ᩿ᇶ‽䛺䛹䚸䛣䛾◊✲䛿ၥ㢟䛜䛒䛳䛯䚹䠄䠆୍༸ᛶ཮⏕ඣ䛿పᰤ㣴䚸పయ㔜䛻䛺䜚䛜䛱䛺䛣䛸䜢⪃៖䛧䛶䛔䛺䛔䠅• 1943ᖺ ⡿ᅜ䛷䚸⮬㛢⑕䛾ึሗ࿌ 䠄䜹䝘䞊་ᖌ䠅⮬㛢⑕䛿ẕぶ䛾⫱䛶᪉䛜ᝏ䛔䛸䛔䛖䇾෭ⶶᗜ䝬䝄䞊ㄝ䇿䛜ᥦၐ䚹䇾⮬㛢⑕䛾ཎᅉ䇿䛾Ṕྐ⮬㛢⑕䛾㑇ఏᏊ◊✲䛛䜙䜟䛛䛳䛯⎔ቃせᅉ䛾㔜せᛶ

௧࿴4ᖺ7᭶12᪥ ᩥ㒊⛉Ꮫ┬㈨ᩱ䜘䜚᪥ᮏ䛻䛚䛡䜛Ⓨ㐩㞀ᐖ
ᐖඣ䛾ቑຍ
ຍຍ-㏻⣭

ከᅉᏊ⑌ᝈ

⮬㛢⑕䛺䛹Ⓨ㐩㞀ᐖ⢭⚄ⓗ䝇䝖䝺䝇
⎔ቃ໬Ꮫ≀㉁
ᨺᑕ⥺
⏕ά⩦័
etc.

㽢

etc.

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8

༢୍㑇ఏᏊ⑌ᝈ

• ୍ሷᇶከᆺ䠄SNP䠅• 㑇ఏᏊኚ␗
• ᰁⰍయ␗ᖖ㑇ఏせᅉ⚄ᡞ኱Ꮫ ᫍಙᙪᩍᤵ㈨ᩱ䜘䜚䛜䜣䛺䛹䜋䛸䜣䛹䛾⑌ᝈ䛻㑇ఏせᅉ䛸⎔ቃせᅉ䛜䛒䜛䚹⎔ቃせᅉ䛿ኚ䛘䜛䛣䛸䛜䛷䛝䜛

஦ᨾ䚸እയ

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⎔ቃせᅉ

⑌ᝈⓎ⑕䠙
⑌ᝈⓎ⑕

⑌ᝈⓎ⑕
⑕䞊㑇ఏせᅉ䛸⎔ቃせᅉⓎ㐩㞀ᐖ䛿ಶᛶ䛾ᘏ㛗䛸䜒⪃䛘䜙䜜䚸⣲ᬕ䜙䛧䛔⬟ຊ䜢Ⓨ᥹䛩䜛᪉䛜኱ໃ䛔䛶䚸୍ᴫ䛻ᝏ䛔䛸䛿䛔䛘䛺䛔䚹䛧䛛䛧䚸䝁䝭䝳䝙䜿䞊䝅䝵䞁䛻ᨭ㞀䛜䛒䜛䜿䞊䝇䛜ከ䛟䚸ᮏே䜒࿘ᅖ䜒ⱞປ䛩䜛䚹6⎔ቃせᅉ䛷ᛴቑ䛧䛶䛔䜛䛺䜙ཎᅉ✲᫂䛜ᚲせ䛷䛿䛺䛔䛛䚹ᰤ㣴䚸ᐙᗞ䞉♫఍⎔ቃ䛺䛹」㞧䛺ཎᅉ䛜⪃䛘䜙䜜䜛䛜䚸㎰⸆䛺䛹᭷ᐖ䛺⎔ቃ໬Ꮫ≀㉁䛾᭚㟢䛜୍ᅉ䛸䛩䜛◊✲䛜⵳✚䛧䛶䛝䛶䛔䜛䚹䠎䠊⎔ቃせᅉ䛜኱䛝䛟㛵䜟䛳䛶䛔䜛ྍ⬟ᛶ㑇ఏᏊ䛿䚸᪥ᮏே඲య䛺䛹㞟ᅋ䛷䚸▷ᮇ㛫䛻䛿ኚ䜟䜙䛺䛔䠍䠊㑇㑇ఏせᅉ䛷䛿ㄝ᫂䛜䛴䛛䛺䛔᫇䛛䜙Ⓨ㐩㞀ᐖ䛿䛒䛳䛯䛜䚸㏆ᖺ䛾ᛴቑ䛻䛿ཎᅉ䛜䛒䜛䛿䛪䟿Ⓨ㐩㞀ᐖᛴቑ䛾ཎᅉ12ே㛫䛾⾜ື䛿䚸䛩䜉䛶䛭䛾⾜ື䜢ᢸ䛖⚄⤒ᅇ㊰䛜ാ䛔䛶䛔䜛䚹⚄⤒ᅇ㊰䛿䚸⎔ቃせᅉ䠄໬Ꮫ≀㉁⎔ቃ䛸እ⏺䛛䜙䛾่⃭䠅䛻䜘䛳䛶ಶ䚻䛻ᑡ䛧䛪䛴㐪䛳䛶స䜙䜜䜛䠄ಶᛶ䛾㐪䛔䠅䝅䝘䝥䝇⤖ྜ䛿ྍረᛶ䠄ኚ໬䛧䜔䛩䛔䠅䛜䛒䜛䛾䛷䚸୍᪦䛷䛝䛯ᅇ㊰䜒ኚ䜟䜛ྍ⬟ᛶ䛜䛒䜛

10䝠䝖䛾⬻䛾Ⓨ㐩䛾ᇶ┙䛿䚸㑇ఏᏊDNA䚹DNA䛿タィᅗ䛻䛩䛞䛪䚸㑇ఏᏊⓎ⌧
䛜㔜せ䚹㑇ఏᏊⓎ⌧䜢ㄪ⠇䛧䛶䛔䜛኱䛝䛺䠎䛴䛾ᰕ䛿䚸䝩䝹䝰䞁౫Ꮡᛶ䚸እ㒊
11⎔ቃ䛛䜙䛾่⃭䛻䜘䜛⚄⤒άື౫Ꮡᛶ䛾ㄪ⠇䚹䜶䝁䝏䝹ㄪᰝ

⬻䛾㧗ḟᶵ⬟䜢ᢸ䛖኱⬻⓶㉁䛾⚄⤒ᅇ㊰䛸䝅䝘䝥䝇⤖ྜ

9䠎䠊䝠䝖䛾⬻䛾Ⓨ㐩

https://www.env.go.jp/chemi/ceh/index.html ᪂᝟ሗ䛜ᥖ㍕

2011ᖺ
ᖺ㛤ጞ䚸⌧ᅾ䚸㐍⾜୰䚸2014ᖺ䛛䜙5000ே䛾ヲ⣽ㄪᰝ

2022ᖺ 40ṓ䜎䛷ㄪᰝ䛻ኚ᭦Ꮚ䛹䜒䜈䛾೺ᗣᙳ㡪 Ⓨ㐩㞀ᐖ䛾ᛴቑ㑇ఏᏊⓎ⌧䛾ᴫせ

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㑇
ఏ
Ꮚ
Ⓨ
⌧

13

඲䛶䛾⣽⬊䛿ྠ䛨㻰㻺㻭䠄㑇ఏ᝟ሗ䠅䜢ᣢ䛳䛶䛔䜛䚹⬻䛾Ⓨ㐩䛻䛿䚸⭾኱䛺✀㢮䛾䝍䞁䝟䜽㉁䜢ᚲせ㔞䚸ḟ䚻䛻స䜛ᚲせ䛜䛒䜚䚸㑇ఏᏊⓎ⌧䛜㔜せ䚹㻰㻺㻭䛿タィᅗ䛷䛧䛛䛺䛟䚸㑇ఏᏊⓎ⌧䛿䚸⏕⌮ⓗ䛺໬Ꮫ≀㉁⩌䛾」㞧䛺཯ᛂ䛷䚸䝩䝹䝰䞁䜔እ㒊䛛䜙䛾่⃭䛷⢭⦓䛻ㄪ⠇䛥䜜䛶ᶵ⬟䛩䜛䚹እ㒊䛛䜙䛾่⃭䜒䚸⚄⤒ఏ㐩≀㉁䛺䛹䛾໬Ꮫ≀㉁䛻ኚ᥮䛥䜜䛶ാ䛟䛯䜑䚸ẅ⹸๣䛺䛹᭷ᐖ໬Ꮫ≀㉁䛻㜼ᐖ䚸᧠஘䛥
䜜䜛䚹
15

⬻

䝍䞁䝟䜽㉁

(䝯
䝯䝑䝉䞁䝆䝱䞊RNA䚸䝍䞁䝟䜽㉁䛾㗪ᆺ䠅

mRNA

DNA

⬻䛾Ⓨ㐩䛾ᇶ┙䛿㑇ఏᏊⓎ⌧⬻䛾Ⓨ㐩䛿䚸⫾ඣᮇ䜒㔜せ䛰䛜䚸ฟ⏕ᚋ䛾Ⓨ㐩䛿⬻䛾㧗ḟᶵ⬟䜢ᢸ䛖⚄⤒ᅇ㊰⥙䛜ฟ᮶䜛㔜せ䛺᫬ᮇ䚹Cowan, Sci Am. 1979;241

Courchesne, Neuron. 2007;56⫾ඣ䞉Ꮚ䛹䜒䛾⬻䛾Ⓨ㐩

14⬻䠄⚄⤒ᅇ㊰䞉䝅䝘䝥䝇䠅䛾Ⓨ㐩㐣⛬⬻䠄⚄⤒ᅇ㊰䝅䝘䝥䝇䠅䛾Ⓨ㐩㐣⛬䛸ẘᛶ䛾䛒䜛໬Ꮫ≀㉁䛾⬻䜈䛾౵ධ⤒㊰ཷᐜయ䜢௓䛧䛶⚄⤒⣔䜔䝩䝹䝰䞁䜢᧠஘䛩䜛⎔ቃ䝩䝹䝰䞁䜔ẅ⹸๣䠄䝅䜾䝘䝹ẘᛶ≀㉁䠅
௨እ䛻DNA䛻ᙳ㡪䜢ཬ䜌䛩≀㉁䜔䚸ᶆⓗ䛜୙᫂䛾⚄⤒ẘᛶ≀㉁䜒䛒䜛

⮬㛢⑕䛺䛹Ⓨ㐩㞀ᐖ䝠䝖䛾⬻䛾Ⓨ㐩䜢᧠஘䛩䜛⎔ቃ໬Ꮫ≀㉁16

Ⓨ㐩⚄⤒ẘᛶ䛺䛹⎔ቃ䝩䝹䝰䞁䛺䛹

0.32 μg/gCr

䖂84 μg/gCr

PBA

䝟䝷䝧䞁㢮

⥲Ỉ㖟

᭷ᶵ䝣䝑⣲໬ྜ≀䝎䜲䜸䜻䝅䞁㢮**⎔ቃ䝩䝹䝰䞁䚸䜶䝢䝆䜵䝛ኚ␗⎔ቃ䝩䝹䝰䞁䚸䜶䝢䝆䜵䝛ኚ␗

䖂4.4 μg/gCr

䖂0.16 μg/gCr

䖂12 pg-TEQ/g-fat

MEHHP

BPA

⎔ቃ䝩䝹䝰䞁䚸Ⓨ䛜䜣ᛶ⚄⤒ẘᛶ䚸Ⓨ㐩⚄⤒ẘᛶ

䖂1.8 ng/ml

䖂5.2 ng/ml

PFOA⎔ቃ䝩䝹䝰䞁䚸Ⓨ䛜䜣ᛶ䖂1.1 ng/ml

PFOS⎔ቃ䝩䝹䝰䞁䚸Ⓨ㐩⚄⤒ẘᛶ

䖂10 μg/gCr

MBP

௧࿴3ᖺᗘ䛾䝕䞊䝍䚸*௧࿴2ᖺᗘ䚸**ᖹᡂ30ᖺ https://www.env.go.jp/chemi/kenkou/monitoring.html
19䖂䛿᳨ᰝ඲ဨ᳨ฟ䚹ẘᛶ䛻䛴䛔䛶䛿⮬ศ䛜ຍ䛘䛯䜒䛾䛷䚸⎔ቃ┬䛾ぢゎ䛷䛿䛺䛔䚹⎔ቃ┬ ᖹᡂ30ᖺᗘ䡚௧࿴3ᖺᗘ໬Ꮫ≀㉁䛾ே䜈䛾䜀䛟㟢㔞䝰䝙䝍䝸䞁䜾ㄪᰝ䠄ྛᖺ80ே䛛䜙120ே䠅䜘䜚ᘬ⏝⾑ᾮ䝡䝇䝣䜵䝜䞊䝹㢮⎔ቃ 䝣䝍䝹㓟䜶䝇䝔䝹㢮䝩䝹䝰䞁௦ㅰ≀⎔ቃ䝩䝹䝰䞁䚸Ⓨ㐩⚄⤒ẘᛶ

Ⓨ㐩⚄⤒ẘᛶ䛺䛹2.0 μg/gCr

DEP䝯䝏䝹䝟䝷䝧䞁

Ⓨ㐩⚄⤒ẘᛶ䛺䛹

䖂1.5 μg/gCrDMP᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䝢䝺䝇䝻䜲䝗⣔㎰⸆௦ㅰ≀ཎయ䛿Ⓨ㐩⚄⤒ẘᛶ䛺䛹䝕䝇䝯䝏䝹䞉䜰䝉䝍䝭䝥䝸䝗* 䖂0.26 μg/gCr䝛䜸䝙䝁䝏䝜䜲䝗௦ㅰ≀Ⓨ㐩⚄⤒ẘᛶ䛺䛹

䖂0.76 μg/gCr䝆䝜䝔䝣䝷䞁

㎰⸆Ⓨ㐩⚄⤒ẘᛶ䚸⏕Ṫẘᛶ䛺䛹

䖂0.18 μg/gCr䜽䝻䝏䜰䝙䝆䞁

䝛䜸䝙䝁䝏䝜䜲䝗⣔㎰⸆

ᒀ

ẘᛶ䜔ᛶ㉁

୰ኸ್

໬Ꮫ≀㉁ྡ

ศ㢮䞉⏝㏵䛺䛹

ヨᩱ᭷ᐖ䛺⎔ቃ໬Ꮫ≀㉁䛻」ྜ᭚㟢䛧䛶䛔䜛᪥ᮏே䠉䠏

೺ᖖே490ྡ䠄2011䡚2016ᖺ䚸40~60ṓ䠅䛾䝪䝷䞁䝔䜱䜰䛾䝃䞁䝥䝹䜢 ᐃ䚹⾑ᾮㄪᰝ䛿㞴ศゎᛶ໬Ꮫ≀㉁䛻䛴䛔䛶ᐃ䚹䖂䠖᳨ᰝ඲ဨ䛻᳨ฟ †:2011ᖺ䛾䜏᳨ᰝ䚹*TEQ: ẘᛶ➼㔞䠄໬ྜ≀䛻䜘䜚ẘᛶ䛾ᙉ䛥䛜㐪䛖䛾䛷䚸ẘᛶ䛜ᙉ䛔
2,3,7,8-TeCDDẘᛶ䛻᥮⟬䛧䛯್䠅䚹**/g-fat䠖⬡⫫㔜㔞ᙜ䛯䜚䛾⃰ᗘ䚹ẘᛶ䛻䛴䛔䛶䛿⮬ศ䛜ຍ䛘䛯䜒䛾䛷䚸⎔ቃ┬䛾ぢゎ䛷䛿䛺䛔䚹䛂᪥ᮏே䛻䛚䛡䜛໬Ꮫ≀㉁䛾䜀䛟㟢㔞䛻䛴䛔䛶2017䛃䝟䞁䝣䝺䝑䝖䜘䜚ᢤ⢋䠄⎔ቃ┬䠅
http://www.env.go.jp/chemi/dioxin/pamph.html
17

㎰⸆

PFAS

䠏䠊᪥ᮏே䛾໬Ꮫ≀㉁᭚㟢䛾ᐇែ䠉䠍

18

㻝㻚㻣

㻟㻚㻜

㻥㻣㻚㻞

㻜㻚㻤

㻡㻚㻜

㻝㻡㻡㻚㻡

㻠㻚㻜

㻥㻚㻜

㻞㻣㻢㻚㻝

㻝㻡㻚㻠

䝟䞊䝉䞁䝍䜲䝹 㼚㼙㼛㼘㻛㻸
㻞㻡㼠㼔
㻡㻜㼠㼔
㻣㻡㼠㼔

46
Ikenaka Y, et al. Environ Toxicol Chem. 2019 )

1000

㻡㻚㻤

㻝㻜㻜

㻟㻡㻚㻠

䠆

㻡㼠㼔

㻞㻥㻚㻤

㻤㻞㻠㻚㻜

㻢㻟㻚㻤

㻥㻡㼠㼔

20

Oya N, Ito Y, et㻝㻞㻢㻚㻟㻞㻝㻡㻤㻚㻡㻟㻜㻤㻚㻞᭱㧗್㼚㼙㼛㼘㻛㻸

2012䠉2013ᖺ䝃䞁䝥䝹᥇ྲྀ 䠆: ᳨ฟ㝈⏺௨ୗ

㻝㻢㻣㻚㻟

㻠㻚㻥

㼚㼙㼛㼘㻛㻸

ᗄఱ
ᖹᆒ

㻝㻜㻜

㻣㻥㻚㻤

᳨ฟ
⋡㻑

al. Sci Total Environ. 2021)

2019
100

䝢䝺䝇䝻䜲䝗௦ㅰ≀㻟㻙㻼㻮㻭᭷ᶵ䝸䞁௦ㅰ≀䃂㻰㻹㻭㻼䝛䜸䝙䝁䝏䝜䜲䝗⥲㔞㎰⸆

Osaka A, et al. Environ Res. 2016, 147:89-96

ᅜෆ
ෆ㻟ṓඣ
ෆ㻟ṓඣ䠄
ṓඣ䠄
ඣ䠄㻞㻞㻟
䠄㻞㻞
㻞㻞㻟ྡ䠅䛾ᒀ୰䛻᭷ᶵ䝸䞁⣔䚸䝢䝺䝇䝻䜲䝗⣔䛜㻟ྡ䠅䛾ᒀ୰䛻᭷ᶵ䝸䞁⣔ྡ䞁⣔⣔䚸䝢䚸䝢䝺䝇䝻䜲
㻝㻜㻜㻜㻜䠂䚸䝛䜸䝙䝁䝏䝜䜲䝗⣔䛜㻜㻜䛜㻣㻥㻚㻤㻚㻤㻤䠂᳨ฟ

ẘᛶ䛻䛴䛔䛶䛿⮬ศ䛜ຍ䛘䛯䜒䛾䛷䚸⎔ቃ┬䛾ぢゎ䛷䛿䛺䛔䚹ᒀㄪᰝ䛿௦ㅰ䛜᪩䛔≀㉁䛻䛴䛔䛶 ᐃ䚹***/g cr: ᒀ୰䜽䝺䜰䝏䞁䛻ᑐ䛩䜛⃰ᗘ䚹#ND䛿᳨ฟ㝈⏺௨ୗ䚹䛂᪥ᮏே䛻䛚䛡䜛䝎䜲䜸䜻䝅䞁㢮➼䛾䜀䛟㟢㔞䛻䛴䛔䛶201䠓䛃䝟䞁䝣䝺䝑䝖䜘䜚ᢤ⢋䠄⎔ቃ┬⎔ቃಖ೺㒊䝸䝇䜽ホ౯ᐊ䠅http://www.env.go.jp/chemi/dioxin/pamph.html

䝥䝷䝇䝏䝑䜽

㝖⳦๣㎰⸆᪥ᮏே䛾໬Ꮫ≀㉁᭚㟢䛾ᐇែ䠉䠎⎔ቃ䝩䝹䝰䞁≀㉁䛻䛿ዪᛶ䝩䝹䝰䞁᧠஘స⏝䛾䛒䜛䜒䛾䛜ከ䛔䚹⎔ቃ䝩䝹䝰䞁䛿Ḣ⡿䛷つไ䛜㐍䜣䛷䛔䜛䛜䚸᪥ᮏ䛿㔝ᨺ䛧≧ែ
23• 䝩䝹䝰䞁䛾✀㢮䛿ከ䛔䛜䚸⎔ቃ䝩䝹䝰䞁䛻䜘䜛௚䛾䝩䝹䝰䞁䜈䛾ᙳ㡪䛿䚸䜋䜌ㄪ䜉䜙䜜䛶䛔䛺䛔䚹•• ⌧ᅾ䚸WHO䛺䛹䛷ෆศἪ᧠஘≀㉁䛸䛧䛶ᣦᐃ䛥䜜䛶䛔䜛䛾䛿䚸ዪᛶ䝩䝹䝰䞁䚸⏨ᛶ䝩䝹䝰䞁䚸⏥≧⭢䝩䝹䝰䞁䜈䛾ᙳ㡪䚹• 䝩䝹䝰䞁䜔⎔ቃ䝩䝹䝰䞁䛾స⏝䛿䚸㏻ᖖ䛾ẘ≀䛾䜘䛖䛺⏝㔞┦㛵ᛶ䛷䛿䛺䛟䚸㧗⃰ᗘ䛷䛛䛘䛳䛶ᙳ㡪䛜ᙅ䜎䜛䛣䛸䛜䛒䜛䚹㧗⃰ᗘ䛻䛺䜛䛸యෆ䛷䝣䜱䞊䝗䝞䝑䜽཯ᛂ䛜㉳䛝䜛䛯䜑䛸⪃䛘䜙䜜䜛䚹• 䝩䝹䝰䞁䛜ప⏝㔞䛷ຠᯝ䜢♧䛩䜘䛖䛻䚸⎔ቃ䝩䝹䝰䞁䛿ప⏝㔞䛷䚸䝩䝹䝰䞁స⏝䜢᧠஘䛧䚸య䜔⬻䛾Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䚹• య䜔⬻䛾Ⓨ㐩䛻䛿䚸ෆศἪ⣔䛾ാ䛝䛜ᚲ㡲䚹 ᛶ䝩䝹䝰䞁䛿⏕Ṫ⣔䜔⬻䛾ᛶศ໬䛰䛡䛷䛺䛟䚸ከᵝ䛺ാ䛝䜢䛧䛶䛔䜛䚹䝩䝹䝰䞁䜢᧠஘䞉㜼ᐖ䛩䜛䝥䝷䝇䝏䝑䜽ᡂศ䜔㎰⸆䛺䛹
䝩䝹
䝩
䜢᧠஘
஘ 㜼
㜼ᐖ䛩䜛䝥䝷䝇䝏䝑䜽ᡂศ䜔㎰⸆䛺䛹䠑䠊䠊䝅䜾䝘䝹ẘᛶ䠍䞊䞊ෆศἪ⣔䜢᧠஘䛩䜛⎔ቃ䝩䝹䝰䞁୍㒊䛾་⸆ရ䚸ឤᰁ⑕䜔⭠ෆ⣽⳦ྀ䛾␗ᖖ䛺䛹ච␿⣔䜈䛾ᙳ㡪䛺䛹• 㔜㔠ᒓ㢮䚸኱Ẽởᰁ䚸䝘䝜䝥䝷䝇䝏䝑䜽䚸᪩⏘䞉పయ㔜ฟ⏕䚸⹢ᚅ䞉䝛䜾䝺䜽䝖䚸
21

22ዪᛶ䝩䝹䝰䞁
⏨ᛶ䝩䝹䝰䞁
⏥≧⭢䝩䝹䝰䞁
etcฟ඾䠖䛂ᆅ⌫䜢⬣䛛䛩໬Ꮫ≀㉁䛃ᾏ㬆♫ ᮌᮧ䞊㯮⏣⣧Ꮚ⠂Ỉ⁐ᛶ䛾䝩䝹䝰䞁䛿䚸⣽⬊⭷䛻䛒䜛ཷᐜయ䛻⤖ྜ䛩䜛䛸䚸⣽⬊ෆ䛾2ḟ䝯䝑䝉䞁䝆䝱䞊䛾⃰ᗘ䛜ୖ᪼䛧䚸≉ᐃ䛾⺮ⓑ㉁䛜ቑ䛘䛯䜚䚸≉ᐃ䛾㑇ఏᏊⓎ⌧䛜ಁ㐍䛧䛯䜚䛩䜛䚹 24䜸䜻䝅䝖䝅䞁
䝞䝋䝥䝺䝑䝅䞁
䜲䞁䝅䝳䝸䞁 etcᛶ䝩䝹䝰䞁䜔⏥≧⭢䝩䝹䝰䞁䛺䛹⬡⁐ᛶ䛾䝩䝹䝰䞁䛿䚸⣽⬊⭷䜢㏻㐣䛧䚸⣽⬊ෆ䛻䛒䜛ཷᐜయ䛻⤖ྜ䛧䛶䚸≉ᐃ䛾㑇ఏᏊⓎ⌧䜢ಁ㐍䛩䜛䚹䝩䝹䝰䞁䛾స⏝• ᶆⓗ䛾ཷᐜయ䛿༢୍䛸䛿㝈䜙䛪䚸」ᩘ䛾ᶆⓗ䜢䜒䛴䜒䛾䜒䛒䜛䚹• 䝅䜾䝘䝹ẘᛶ䛿䚸䝩䝹䝰䞁స⏝䜢᧠஘䛩䜛⎔ቃ䝩䝹䝰䞁䚸እ㒊䛛䜙䛾่⃭䜢᧠஘䛩䜛ẅ⹸๣䛺䛹⚄⤒᧠஘≀㉁䛜䛒䜛䚹䛭䛾௚䛾⬻䜈䛾ᙳ㡪䠖⚄⤒ẘᛶ䛾☜ㄆ䛥䜜䛶䛔䜛᭷ᐖ໬Ꮫ≀㉁䛺䛹

㉳䛣䛩≀㉁ 䝡䝇䝣䜵䝜䞊䝹A䚸䝎䜲䜸䜻䝅䞁䚸䜾䝸䝩䝃䞊䝖䛺䛹• ⬻䛾Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩≀㉁䛿䚸ᚑ᮶䛾ẘᛶ䜢ᣢ䛴᭷ᐖ໬Ꮫ≀㉁௨እ
䛻䚸ཷᐜయ䜢௓䛧䛯䝅䜾䝘䝹ẘᛶ䜢ᣢ䛴᭷ᐖ໬Ꮫ≀㉁䛜䛒䜛䚹

JEPA䝙䝳䞊䝇91ྕ❧ᕝᾴ䞉ඖ௦⾲䛸Ⳣ㔝⣧ඛ⏕䛾ᑐㄯ䜘䜚䝅䜾䝘䝹ẘᛶ

• DNA䛾ሷᇶ㓄ิ䛻䛿ᙳ㡪䛧䛺䛔䛜䚸DNA䝯䝏䝹໬␗ᖖ䛺䛹DNA䛾ಟ㣭䛻ኚ␗䜢• ᨺᑕᛶ≀㉁䜔✺↛ኚ␗ཎᛶ䜢ᣢ䛴᭷ᐖ໬Ꮫ≀㉁→DNAሷᇶ㓄ิ䛾ኚ␗

DNA䛻✺↛ኚ␗䜢㉳䛣䛩≀㉁䜔䜶䝢䝀䝜䝮␗ᖖ䜢㉳䛣䛩≀㉁䝎䜲䜸䜻䝅䞁䛺䛹㞴ศゎᛶ᭷ᶵởᰁ≀㉁䠄POPs)㞴⇞๣PBDE䚸᭷ᶵ䝣䝑⣲໬ྜ≀䚸⎔ቃ䝩䝹䝰䞁స⏝䛾䛒䜛㎰⸆㢮䚸PCB䚸䝥䝷䝇䝏䝑䜽䛻ྵ䜎䜜䜛䝣䝍䝹㓟䜶䝇䝔䝹㢮䚸䝡䝇䝣䜵䝜䞊䝹㢮䜔ῧຍ๣䚸• 䝩䝹䝰䞁స⏝䜢᧠஘䛩䜛⎔ቃ䝩䝹䝰䞁䠄ෆศἪ᧠஘≀㉁䠅

᭷ᶵ䝸䞁⣔䚸䝢䝺䝇䝻䜲䝗⣔䚸䝛䜸䝙䝁䝏䝜䜲䝗⣔䚸䜹䝹䝞䝯䞊䝖⣔䚸᭷ᶵሷ⣲⣔⬻⚄⤒⣔䜢ᶆⓗ䛻䛧䛯ẅ⹸๣• ⬻Ⓨ㐩䛻ᚲせ䛺እ㒊่⃭䜢䚸┤᥋᧠஘䛩䜛⚄⤒᧠஘≀㉁䝅䜾䝘䝹ẘᛶ ཷᐜయ䜢௓䛧䛯ẘᛶ

䠐䠊Ⓨ㐩㞀ᐖ䛾せᅉ䛸䛺䜛᭷ᐖ໬Ꮫ≀㉁䛾✀㢮⏥≧⭢䝩䝹䝰䞁䠃
OH-PCB106ῧຍ

OH-PCB106ῧຍ

50pM

DNA

⺮ⓑ㉁

mRNA

DNA

⺮ⓑ㉁

mRNA

⬻䛾Ⓨ㐩䛻ᚲせ䛺⺮ⓑ㉁

⿵ຓ
ᅉᏊ⩌

㑇ఏᏊ

㑇
ఏ
Ꮚ

Ọ㐲䛾໬Ꮫ≀㉁䠄forever chemicals)䝎䜲䜸䜻䝅䞁⎔ቃ䝩䝹䝰䞁ᑐ⟇ᅜẸ఍㆟䝟䞁䝣䜘䜚Ἀ⦖䚸኱㜰䚸ᮾிከᦶᆅ༊䛷㧗⃰ᗘởᰁ඲ᅜྛᆅ䛷᳨ฟ䛥䜜䛶䛔䜛

Kim JI et al. Sci Total Environ. 2023 ;879:27

㡑ᅜ䛾◊✲䠖2ṓඣ䛷PFAS䛾⾑୰⃰ᗘ䛜㧗䛔Ꮚ䛹䜒䛻ADHD䛾䝸䝇䜽䛜ୖ᪼䚹᭷ᶵ䝣䝑⣲໬ྜ≀PFOS, PFOA䛿᧕Ỉᛶ䚸㜵Ỉᛶ䛺䛹䛾ᛶ㉁䛛䜙䚸ከ⏝䛥䜜䛶䛝䛯䚹኱㔞౑⏝ᚋ䚸㞴ศゎᛶ䚸⏕Ṫẘᛶ䚸⏥≧⭢䝩䝹䝰䞁᧠஘స⏝䚸Ⓨ䛜䜣ᛶ䚸₽⒆ᛶ኱⭠⅖
Ⓨ⑕䝸䝇䜽䛜☜ㄆ䛥䜜䚸᪤䛻ᅜ㝿ⓗ䛺ἲつไᑐ㇟䛻䛺䛳䛶䛔䜛䚹௦᭰䛾PFHxS䜒⎔ቃ䝩䝹䝰䞁స⏝䛜ሗ࿌䛥䜜䚸⎔ቃởᰁ䚸ேయởᰁ䛜☜ㄆ䛥䜜䚸2022ᖺ䠒᭶䛻ᅜ㝿ⓗ䛺つไᑐ㇟䛜Ỵ䜎䛳䛯䚹䛭䜜௨እ䛾᭷ᶵ䝣䝑⣲໬ྜ≀䜒䚸ྠᵝ䛺ẘᛶ䛜ᠱᛕ䚹᭷ᶵ䝣䝑⣲໬ྜ≀䠖⣙4700✀⏥≧⭢䝩䝹䝰䞁䠃
OH-PCB106ῧຍ

BPA䛿ዪᛶ䝩䝹䝰䞁䚸⏨ᛶ䝩䝹䝰䞁䚸⏥≧⭢䝩䝹䝰䞁䛺䛹䛾᧠஘䚸DNA䝯䝏䝹໬␗ᖖ䛺䛹ከᵝ䛺ᙳ㡪䛜ሗ࿌䛥䜜䛶䛔䜛

OH-PCB106ῧຍ䝁䞁䝖䝻䞊䝹

ዪᛶ䝩䝹䝰䞁䛿ᛶศ໬䛰䛡䛻ാ䛟䛾䛷䛿䛺䛟䚸⬻䛾Ⓨ㐩䜔グ᠈䚸Ꮫ⩦䛻䜒㔜せ䛺ാ䛝䜢䛧䛶䛔䜛䚹⏨ዪඹ䛻ዪᛶ䝩䝹䝰䞁䚸⏨ᛶ䝩䝹䝰䞁䛾䝞䝷䞁䝇䛜㔜せ䚹䝠䝖⬻䛾ᛶᕪ䛿䚸ᚑ᮶䜘䜚⏨ዪ䛷2䛴䛻༊ศ䛥䜜䜛䜟䛡䛷䛿䛺䛟䚸ከᵝᛶ䛜䛒䜛䚹䝠䝖䛾⬻䛾⏨ዪᕪ䛿䚸䛢䛳ṑ㢮䜔௚䛾㟋㛗㢮䜋䛹᫂䜙䛛䛷䛺䛟䚸ಶேᕪ䛾᪉኱䛝䛔䛸䛔䛖ㄝ䜒䛒䜛䚹⬻䛾Ⓨ㐩䛾⮫⏺ᮇ䛻䚸ዪᛶ䝩䝹䝰䞁㢮ఝ䛾⎔ቃ䝩䝹䝰䞁䛻᭚㟢䛩䜛䛸䚸⬻䛾ᛶศ໬䛻ᙳ㡪䜢ཬ䜌䛩ྍ⬟ᛶ䛜䛒䜛䚹
ື≀ᐇ㦂䛷䛿䚸䝡䝇䝣䜵䝜䞊䝹A䛺䛹䛷䚸⬻䛾ᛶᕪ䜔ᛶ⾜ື䛾ኚ໬䛺䛹䛜ከᩘሗ࿌䛥䜜䛶䛔䜛䚹⫾ඣ䛾⮫⏺ᮇ䛻䚸⢭ᕢ䛷⏘⏕䛥䜜䛯䝔䝇䝖䝇䝔䝻䞁䠄⏨ᛶ䝩䝹䝰䞁䛾1✀䠅䛜⬻䛻ാ䛝䚸⬻䛾ᛶศ໬䛜㉳䛣䜛䚹䝠䝖䛾ሙྜ䚸⮫⏺ᮇ䛿⫾⏕12㐌䛛䜙22㐌㡭䛸᥎ᐃ䚹

ᛶ䝩䝹䝰䞁䛾⬻Ⓨ㐩䜈䛾ᙺ๭⬻䛾Ⓨ㐩䛻䛚䛡䜛ᛶ䝩䝹䝰䞁䛾ᶵ⬟䠬䠟䠞⏥≧⭢䝩䝹䝰䞁
ཷᐜయ

᰾

Ⓨ
⌧
䛩
⏥≧⭢䝩䝹䝰䞁ᛂ⟅ᅉᏊゎ㞳 䜛

⚄⤒⣽⬊

᭷ᶵ
ᶵ䝣䝑⣲໬ྜ≀≀㻼㻲㻭㻿㻭㻿䛾⎔ቃ䝩䝹䝰䞁స⏝⬻䛾Ⓨ㐩䛻ᚲせ䛺⺮ⓑ㉁

⿵ຓ
ᅉᏊ⩌

㑇ఏᏊ

Ⓨ
⌧
䛩
䜛
㑇
ఏ
Ꮚ

PCB䛿䚸⏥≧⭢䝩䝹䝰䞁ཷᐜయ䛜DNAୖ䛾⏥≧⭢䝩䝹䝰䞁ᛂ⟅ᅉᏊ䛻≉␗ⓗ䛻⤖ྜ䛩䜛䛣䛸䜢㜼ᐖ⏥≧⭢䝩䝹䝰䞁᧠஘స⏝䛿䚸PCB௨እ䛻PBDE, PFOS, PFOA䛺䛹䛷ሗ࿌䛥䜜䛶䛔䜛⏥≧⭢䝩䝹䝰䞁

⏥≧⭢䝩䝹䝰䞁
ཷᐜయ᰾⏥≧⭢䝩䝹䝰䞁ᛂ⟅ᅉᏊ⤖ྜ⚄⤒⣽⬊⏥≧⭢䝩䝹䝰䞁䛸䛭䛾ཷᐜయ䛻䜘䜛⏥≧⭢䝩䝹䝰䞁䛸䛭
䞁䛸䛭
䛭䛾ཷ
䛾ཷ
ཷᐜయ䛻䜘䜛
ཷᐜ㑇ఏᏊⓎ⌧䛻䛚䛡䜛䜛㻼㻯㻮㻮䛾㜼ᐖ䞉᧠஘స⏝PCB㢮䛿䚸䛤䛟ప⏝㔞䛷⚄⤒⣽⬊䛾⏥≧⭢䝩䝹䝰䞁౫Ꮡᛶ䛾✺㉳ఙᒎ䜢㜼ᐖ䛧
⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䚹⏥≧⭢䝩䝹䝰䞁䛿Ꮚ䛹䜒䛾Ⓨ㐩䛻ᴟ䜑䛶㔜せ䚹

Kimura-Kuroda, J et al. Develop. Brain Res 2002⏥≧⭢䝩䝹䝰䞁ῧຍ1䝁䞁䝖䝻䞊䝹

㻼㻯㻮㻮䛿⚄⤒⣽⬊䛾⏥≧⭢䝩䝹䝰䞁䛻䛻䜘䜛ᡂ㛗䜢
䜢㜼ᐖ•⏥≧⭢䝩䝹䝰䞁䠃
OH-PCB106ῧຍฟ඾䠖䛂ᆅ⌫䜢⬣䛛䛩໬Ꮫ≀㉁䛃
ᾏ㬆♫ ᮌᮧ䞊㯮⏣⣧Ꮚ⠂䜸䜻䝅䝖䝅䞁䛿䚸⮬㛢⑕䜔⤫ྜኻㄪ⑕䚸䜰䝹䝒䝝䜲䝬―⑓䛺䛹⢭⚄⑌ᝈ䛸䛾㛵㐃䜒ሗ࿌䛥䜜䛶䛔䜛䚹⎔ቃ䝩䝹䝰䞁䛜䜸䜻䝅䝖䝅䞁䚸䝞䝋䝥䝺䝑䝅䞁䛾Ⓨ⌧䛻ᙳ㡪䜢ཬ䜌䛩◊✲ሗ࿌䜒䛒䜛䚹
PCB, BPA, 䝣䝍䝹㓟䜶䝇䝔䝹䚸᭷ᶵ䝸䞁⣔㎰⸆䛾᭚㟢䛜䚸䜸䜻䝅䝖䝅䞁䜔䝞䝋䝥䝺䝑䝅䞁䛻ᙳ㡪䜢ཬ䜌䛩䛣䛸䛜ሗ࿌䛥䜜䛶䛔䜛䚹䛣䜜䜙䛾᭷ᐖ໬Ꮫ≀㉁䛜䚸┤᥋ᙳ㡪䛩䜛䛾䛛䚸䜶䝇䝖䝻䝆䜵䞁䜢௓䛧䛯ᙳ㡪䛺䛾䛛䛿䜟䛛䛳䛶䛔䛺䛔䚹

OH-PCB106ῧຍ䝁䞁䝖䝻䞊䝹

䝞䝋䝥䝺䝑䝅䞁䛿䚸䜸䜻䝅䝖䝅䞁
䛸㏫䛾ാ䛝䜢䛩䜛䝩䝹䝰䞁䛷䚸୧᪉䛾䝞䝷䞁䝇䛜㔜せ䚹䜸䜻䝅䝖䝅䞁䛿ឡ䛸ಙ㢗䛾䝩䝹䝰䞁䛸䛧䛶ὀ┠䛥䜜䛶䛔䜛䚹⎔ቃ䝩䝹䝰䞁䛿䜸䜻䝅䝖䝅䞁䛻䜒ᙳ㡪

OH-PCB106ῧຍ
OH-PCB106ῧຍḢᕞ䛾␿Ꮫ◊✲䛛䜙䚸Ꮚ䛹䜒䛾⬻Ⓨ㐩䜈ᝏᙳ㡪䛜☜ㄆ䛥䜜䛶䛔䜛⎔ቃ䝩䝹䝰䞁䛾ΰྜ≀(BPA, 䝣䝍䝹㓟䜶䝇䝔䝹㢮4✀䚸PFAS3✀䠅䜢సᡂ䛧䚸䝠䝖⚄⤒⣔ᇵ㣴⣽⬊䜔䝊䝤䝷䝣䜱䝑䝅䝳䛺䛹䛻ప⏝㔞䛷ᢞ୚䛩䜛䛸䚸⮬㛢⑕㛵㐃㑇ఏᏊ䛾Ⓨ⌧␗ᖖ䜔⏥≧⭢䝩䝹䝰䞁᧠஘䛺䛹䛜㉳䛣䜛䚹ⴭ⪅䜙䛿䚸䛣䜜䜙䛾᭚㟢䛾༴㝤ᛶ䜢㆙࿌

Caporale N et al. From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures.
Science. 2022 Feb 18;375(6582)⏥≧⭢䝩䝹䝰䞁䠃

䝅䝷䝭㥑㝖๣䠄ᅜෆ䛾㎰⸆Ⓩ㘓䛺䛧䠅 䝇䝭䝇䝸䞁䠄㻱㼁䛷䛿ẅ⹸๣䠅ኻຠ 㻞㻜㻜㻥

⮯໬䝯䝏䝹䠄ୡ⏺䛷⚗Ṇ䛜㐍䜐䠅 ኻຠ 㻞㻜㻝㻝ᅵተ⇺↮๣ 䠄䜸䝌䞁ᒙ◚ቯ䠅ኻຠ 㻞㻜㻝㻝ኻຠ 㻞㻜㻝㻤ኻຠ 㻞㻜㻜㻤

䝥䝻䝟䝙䝹

䝆䜴䝻䞁

䜰䝉䝖䜽䝻䞊䝹

㝖ⲡ๣

㝖ⲡ๣

㝖ⲡ๣

32

ᐙᗞ⏝䛻౑⏝୰

౑⏝୰

౑⏝୰

౑⏝୰

౑⏝୰

౑⏝୰

ኻຠ 2004䝅䝬䝆䞁 (CAT)
㝖ⲡ๣

౑⏝୰

ኻຠ 2004
䜰䝖䝷䝆䞁

㝖ⲡ๣

౑⏝୰

ኻຠ 2006䜰䝷䜽䝻䞊䝹

౑⏝୰
㝖ⲡ๣

౑⏝୰

ኻຠ 2017౑⏝୰౑⏝୰ኻຠ 2006ኻຠ 㻞㻜㻝㻠౑⏝୰౑⏝୰ኻຠ 2000
ኻຠ 2007౑⏝୰᪥ᮏኻຠ 2007EUኻຠ 㻞㻜㻝㻠
㻠㻌

䝬䞁䝊䝤

ẅ⳦๣

䝬䞁䝛䝤

ẅ⳦๣

䝏䝷䜴䝮

䝥䝻䝅䝭䝗䞁ẅ⳦๣ẅ⳦๣䝣䜵䝙䝖䝻䝏䜸䞁

䝨䝹䝯䝖䝸䞁

䝢䝺䝇䝻䜲䝗⣔ẅ⹸๣᭷ᶵ䝸䞁⣔ẅ⹸๣䜹䝹䝞䝸䝹 (NAC)䜹䝹䝞䝯䞊䝖⣔ẅ⹸๣

㎰⸆ྡ

32

௦⾲ⓗ䛺⎔ቃ䝩䝹䝰䞁≀㉁ୗグ௨እ䛻䜒ከ✀㢮䛾⎔ቃ䝩䝹䝰䞁≀㉁䛜ሗ࿌䝡䝇䝣䜵䝜䞊䝹㢮 BPA䚸BPS, BPF䛺䛹
䝣䝍䝹㓟䜶䝇䝔䝹㢮
DEHP, DBP, BBP, DINP, DIDP, DNOP䛺䛹
⏥≧⭢䝩䝹䝰䞁䠃
OH-PCB106ῧຍ⮯⣲⣔㞴⇞๣
PBDE䚸䝫䝸⮯⣲໬䝡䝣䜵䝙䞊䝹䚸䝔䝖䝷䝤䝻䝰BPA䛺䛹OH-PCB106ῧຍ䝸䞁⣔㞴⇞๣ 䝸䞁㓟䝖䝸䝣䜵䝙䝹䛺䛹⣸እ⥺྾཰๣ UV-328䚸䜸䜻䝅䝧䞁䝌䞁䛺䛹•ከᩘ䛾␿Ꮫ◊✲䜢ゎᯒ䛧䛯⥲ㄝ䚹BPA䜔䝣䝍䝹㓟䜶䝇䝔䝹㢮䛾⫾ඣᮇ䛾᭚㟢䛿䚸⬻䛾Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䛸⤖ㄽ䚹䛸䛟䛻BPA䛿ADHD䛾Ⓨ⑕䝸䝇䜽䜢ୖ䛢䜛䚹㎰⸆䛾✀㢮䝬䜲䜽䝻䝥䝷䝇䝏䝑䜽䛿䚸ᾏὒ䚸኱Ẽ䚸ᅵተ䚸ேయ䠄⾑ᾮ䚸⫵䚸⫾┙䛺䛹䠅䚸඲䛶䛻᳨ฟ䛥䜜䛶䛔䜛䚹䝬䜲䜽䝻䝥䝷䝇䝏䝑䜽䛿䛥䜙䛻ᚤᑠ䛺䝘䝜䝥䝷䝇䝏䝑䜽䛻䛺䜚䚸⾑ᾮ⬻㛵㛛䜢㏻㐣䛧䚸⚄⤒⣔䛻ᝏᙳ㡪䜢ཬ䜌䛩ྍ⬟ᛶ䛜䛒䜛䚹•

Minatoya M 䠃Kishi R. A Review of Recent Studies on Bisphenol A and Phthalate Exposures
and Child Neurodevelopment. Int. J. Environ. Res. Public Health 2021, 18(7), 3585

⎔ቃ䝩䝹䝰䞁స⏝䚸Ⓨ䛜䜣ᛶ䚸⚄⤒ẘᛶ䛺䛹䛜ሗ࿌䛥䜜䛶䛔䜛䝡䝇䝣䜵䝜䞊䝹㢮䚸䝣䝍䝹㓟䜶䝇䝔䝹㢮䚸PFAS䚸⮯⣲⣔㞴⇞๣䚸䝸䞁⣔㞴⇞๣䛺䛹䝁䞁䝖䝻䞊䝹
䛥䜙䛻䝘䝜䝥䝷䝇䝏䝑䜽䛜⾑ᾮ⬻㛵㛛䜢㏻㐣䛧䚸⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩ྍ⬟ᛶ䜢ᣦ᦬䝥䝷䝇䝏䝑䜽䛾㐣๫౑⏝䛻䜘䜛⎔ቃ◚ቯ䜔䝠䝖䜈䛾೺ᗣᙳ㡪䛻㛵䛩䜛⥲ㄝ䝥䝷䝇䝏䝑䜽ᡂศ䛜Ꮚ䛹䜒䛾⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䛣䛸䛻ὀ┠㻱㼁㼁䛷ኻຠ䛧䛶䛔䜛⎔ቃ䝩䝹䝰䞁స⏝䛾䛒䜛㎰⸆䝥䝷䝇䝏䝑䜽䛿䚸ຍ⇕䜔Ἔ⬡䚸ຎ໬䛷䚸᭷ᐖᡂศ䛜⁐ฟ䛧䛶䛟䜛ྍ⬟ᛶ䛜㧗䛔䚹䝁䞁䝖䝻䞊䝹

••䝥䝷䝇䝏䝑䜽䛿䚸▼Ἔ䜢୺ཎᩱ䛸䛧䚸ከ✀㢮䛾ῧຍ๣䛜౑⏝䛥䜜䛶䛔䜛䛜ᡂศ䛿බ㛤䛥䜜䛶䛔䛺䛔䛜䚸⎔ቃ䝩䝹䝰䞁స⏝䛺䛹᭷ᐖ䛺໬Ꮫ≀㉁䛜ከ䛔䚹䠄ྍረ๣䠈㓟໬㜵Ṇ๣䠈⇕Ᏻᐃ๣䠈⣸እ⥺྾཰๣䠈㞴⇞๣䠈ᖏ㟁㜵Ṇ๣䠈ᑟ㟁๣䠈ᙉ໬๣䠈ⓎἻ๣䠈඘ሸ๣䠈╔Ⰽᩱ䛺䛹䠅•Landigan PI et al. The Minderoo-Monaco Commission on Plastics and Human Health. Ann
Glob Health. 2023 Mar 21;89(1):23.
㧗⏣⚽㔜ඛ⏕䜔ୡ⏺䛾40ே䛾ⴭ⪅•䝥䝷䝇䝏䝑䜽䛻ྵ䜎䜜䜛ཎᩱ䜔ῧຍ๣䛻䛿䚸⎔ቃ䝩䝹䝰䞁స⏝䜔Ⓨ䛜䜣ᛶ䚸⏕Ṫẘᛶ䚸⚄⤒ẘᛶ䛾䛒䜛䜒䛾䛜ከ䛔䚹䠄ẘᛶ䛿ㄪ䜉䜙䜜䛶䛔䛺䛔≀㉁䛜䜋䛸䜣䛹䠅•⎔ቃ䝩䝹䝰䞁స⏝䛾䛒䜛䝥䝷䝇䝏䝑䜽ཎᩱ䜔ῧຍ๣⎔ቃ䝩䝹䝰䞁䛜⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛧䚸Ⓨ㐩㞀ᐖ䛾䝸䝇䜽䜢ୖ䛢䜛␿Ꮫ◊✲䜔ື≀ᐇ㦂䛿ከᩘሗ࿌䛥䜜䛶䛔䜛 ୍㒊䜢⤂௓

Ⓨ㐩㞀ᐖ䛸⎔ቃ䝩䝹䝰䞁䝙䝁䝏䞁ᛶ
䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䜰䝉䝍䝭䝥䝸䝗䠄䝰䝇䝢䝷䞁䠅䜲䝭䝎䜽䝻䝥䝸䝗䠄䜰䝗䝬䜲䝲䞊䠅

㼼

䠇

䠇

᭷ᶵ䝸䞁⣔

䝛䜸䝙䝁䝏䝜䜲䝗⣔䝣䜵䝙䝹䝢䝷䝌䞊䝹⣔ẅ⹸๣䛿䚸᪻⹸䛾⚄⤒⣔䜢ᶆⓗ䛻䛧䛶䛔䜛䛜䚸᪻⹸䛸ே㛫䛾⚄⤒⣔䛿㢮ఝᛶ䛜䛒䜛䛾䛷䚸䝠䝖䛻䜒ᙳ㡪䜢ཬ䜌䛩䛣䛸䛜䛒䜛䚹

GABAཷᐜయ

Environ. Health Perspect䠄2010䠅Marks AR, et al. ዷ፬䛾ᒀ୰䛻᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䝺䝧䝹䛜ẚ㍑ⓗ䛻㧗䛔䛸䚸⏕䜎䜜䛯Ꮚ䛿⣙䠑ಸADHD䛻䛺䜚䜔䛩䛔

Environ. Health Perspect䠄2011䠅Bouchard MF, et al. ዷ፬䛾ᒀ୰䛻᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䝺䝧䝹䛜ẚ㍑ⓗ䛻㧗䛔䛸䚸⏕䜎䜜䛯Ꮚ䛾▱⬟䠄IQ䠅䛜ᖹᆒ7.0ୗ䛜䜛䚹

Environ. Health Perspect 䠄2011䠅Rauh V, et al. ዷ፬䛾᭷ᶵ䝸䞁⣔㎰⸆䝺䝧䝹䛜ẚ㍑ⓗ䛻㧗䛔䛸䠈⏕䜎䜜䛯Ꮚ䛾సᴗグ᠈⬟ຊ䛜2.8䠂ᝏ䛟䛺䜛䚹

Environ. Health Perspect 䠄2011䠅Engel SM, et al. ዷ፬䛾ᒀ୰䛾᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䛜ẚ㍑ⓗ䛻㧗䛔䛸䚸⏕䜎䜜䛯Ꮚ䛾▱ⓗⓎ㐩䛜ᝏ䛟䛺䜛䚹

Environ. Health Perspect 䠄2018䠅Sagiv SK, et al. ዷ፬䛾ᒀ୰䛾᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䛜ẚ㍑ⓗ䛻㧗䛔䛸䚸⮬㛢⑕䛾䝸䝇䜽䛜㧗䛟䛺䜛䚹

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• ᭷ᶵ䝸䞁⣔ẅ⹸๣䜽䝻䝹䝢䝸䝩䝇䛿䚸⬻䛻ᝏᙳ㡪䜢ཬ䜌䛩䛣䛸䛜᫂䜙䛛䛷䚸EU䛷䛿2020ᖺ
䛻Ⓩ㘓᢯ᾘ䚸⡿ᅜ䛷䜒䚸䝞䜲䝕䞁኱⤫㡿䛜2021ᖺ䚸㣗ရ䜈䛾౑⏝䛿⚗Ṇ䛧䛯䚹᪥ᮏ䛷䛿ᮍ
35䛰䛻౑⏝䛥䜜⥆䛡䛶䛚䜚䚸෌ホ౯䛾ணᐃ䜒Ỵ䜎䛳䛶䛔䛺䛔䚹• ື≀ᐇ㦂䛷䜒᭷ᶵ䝸䞁⣔㎰⸆䛜⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩ㄽᩥ䛿ከᩘ䛒䜛䚹⡿ᅜᑠඣ⛉Ꮫ఍ㄅ Pediatrics䠄2010䠅Bouchard MF, et al.
Ꮚ䛹䜒䛾ᒀ୰᭷ᶵ䝸䞁⣔㎰⸆௦ㅰ≀䝺䝧䝹䛜ẚ㍑ⓗ䛻㧗䛔䛸ADHD䛜⣙䠎ಸ•⎔ቃ໬Ꮫ≀㉁䛾୰䛷䜒᭷ᶵ䝸䞁⣔㎰⸆᭚㟢䛸Ⓨ㐩㞀ᐖ䚸▱⬟పୗ䛻
ቃ Ꮫ≀
䜒᭷
㎰⸆
㐩㞀ᐖ
┦㛵㛵ಀ᭷䜚䛸䛩䜛ㄽᩥ䛜2010ᖺ㡭䛛䜙⌧ᅾ䜎䛷ከᩘ䠄௨ୗ䛿䛭䛾୍㒊䠅Ⓨ㐩⚄⤒ẘᛶ䛾䛒䜛᭷ᶵ䝸䞁⣔㎰⸆

33• ᾐ㏱ᛶ㎰⸆䛿䚸Ỉ䛻⁐䛡䜔䛩䛟᳜≀඲య䛻ᾐ㏱䛧䚸ṧ␃䛩䜛䛸Ὑ䛳䛶䜒ⴠ䛱䛺䛔•䜰䝉䝏䝹䝁䝸䞁ศゎ㓝⣲䝣䜵䝙䝖䝻䝏䜸䞁䠄䝇䝭䝏䜸䞁䠅䝬䝷䝏䜸䞁䠄䝬䝷䝋䞁䠅䝣䜱䝥䝻䝙䝹䠄䝥䝸䞁䝇䠅䜶䝏䝥䝻䞊䝹䠄䜻䝷䝑䝥䠅䜰䝉䝏䝹䝁䝸䞁ศゎ㓝⣲䜹䝹䝞䝸䝹䠄䝕䝘䝫䞁䠅䞊䜹䝹䝞䝯䞊䝖⣔䝘䝖䝸䜴䝮䝏䝱䝛䝹䝨䝹䝯䝖䝸䞁䠄䜰䝕䜱䜸䞁ங๣䠅䞊䝢䝺䝇䝻䜲䝗⣔䝘䝖䝸䜴䝮䝏䝱䝛䝹
GABAཷᐜయ

⚄⤒䛾ᶆⓗ䞊㎰⸆䛾ලయ౛䠄ၟရྡ䠅

᭷ᶵሷ⣲⣔

ᾐ㏱ᛶ

DDT
BHC

୺䛺ẅ⹸๣䛾✀㢮䠒䠊䠊䝅䜾䝘䝹ẘᛶ䠎䞊⚄⤒ఏ㐩⣔䜢᧠஘䛩䜛ẅ⹸๣䠄㎰⸆䠅䝆䝜䝔䝣䝷䞁

䜽䝻䝏䜰䝙䝆䞁

䜰䝉䝍䝭䝥䝸䝗

䜲䝭䝎䜽䝻䝥䝸䝗

ᾐ㏱ᛶ㎰⸆-and-talking-points

36

https://www.epa.gov/safepestcontrol/pesticides-and-their-impact-children-key-facts䠑䠊⡿ᅜ䞉⎔ቃಖㆤᗇEPA䛿䚸㎰⸆䛻䛴䛔䛶Ꮚ䛹䜒䛻䛿䛸䛟䛻ὀព䛩䜛䜘䛖່࿌䜢ฟ䛧䛶䛔䜛
䠑䠊

Risk assessment of substances present in food intended for infants.

ච␿⣔䛺䛹䛾Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䛾䛷䚸᭚㟢䜢ᴟຊୗ䛢䜛䜘䛖ᥦゝ䚹䠐䠊Ḣᕞ㣗ရᏳ඲ᶵ㛵EFSA䛿2017ᖺ䚸㣗ရ୰䛾ṧ␃㎰⸆䜔㣗ရῧຍ≀䛿Ꮚ䛹䜒䛾⬻䜔䠐䠊WHO/UNEP State of the science of endocrine disrupting chemicals-2012.

Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䛸䜎䛸䜑䛯ห⾜≀䜢Ⓨ⾲䚹

3. WHO/UNEP䛿2012ᖺ䚸⎔ቃ䝩䝹䝰䞁䜔኱Ẽởᰁ䚸㎰⸆䛺䛹䛜Ꮚ䛹䜒䛾೺ᗣ䜔⬻䛾

International Journal of Gynecology and Obstetrics , 2015

䛔䜛䛸㆙࿌䜘䜚䚸䝠䝖䛾⏕Ṫ䚸ฟ⏘␗ᖖ䛜ቑ䛘䚸Ꮚ䛹䜒䛾೺ᗣ㞀ᐖ䜔⬻ᶵ⬟䛾Ⓨ㐩㞀ᐖ䛜ቑຍ䛧䛶

2. ᅜ㝿⏘፬ே⛉㐃ྜ䛿2015ᖺ䚸㎰⸆䜔⎔ቃ䝩䝹䝰䞁䛺䛹᭷ᐖ䛺⎔ቃ໬Ꮫ≀㉁᭚㟢䛻Pesticide exposure in children, 2012, Pediatricsཬ䜌䛧೺ᗣ㞀ᐖ䜢㉳䛣䛩䇾䛸බᘧ䛻່࿌䜢Ⓨ⾲䚹

1. ⡿ᅜᑠඣ⛉Ꮫ఍䛿2012ᖺ䚸䇾㎰⸆᭚㟢䛿ᑠඣ䛜䜣䛾䝸䝇䜽䜢ୖ䛢䚸⬻Ⓨ㐩䛻ᝏᙳ㡪䜢䛜䛢ୡ⏺䛷䛿Ꮚ䛹䜒䜢㎰⸆䜔⎔ቃ䝩䝹䝰䞁䛺䛹䛾䛷䛿Ꮚ䛹䜒䜢㎰⸆䜔⎔ቃ䝩䝹䝰䞁䛺᭚㟢䛛䜙Ᏺ䜛ື䛝䛜㐍䜣䛷䛔䜛

34

34

䝭䝒䝞䝏䞉䝖䞁䝪䛜ᾘ䛘䛯䟿䇾ỿ㯲䛾᫓䇿䛜⌧ᐇ䛻㻍㻍䛂ዣ䜟䜜䛧ᮍ᮶䛃䛷㎰⸆䛾⎔ቃ䝩䝹䝰䞁స⏝䜢ᣦ᦬䝛䜸䝙䝁ྠᵝ䛻ᾐ㏱ᛶ䞉䞉䞉䝣䜱䝥䝻䝙䝹䚸䜶䝏䝥䝻䞊䝹ᶆⓗ䛿GABAཷᐜయͤ䝛䜸䝙䝁䝏䝜䜲䝗䛸ྠᵝ䛾స⏝䝺䜲䝏䜵䝹䞉䜹䞊䝋䞁䛂ỿ㯲䛾᫓䛃䛷
㎰⸆䛾༴㝤ᛶ䜢㆙࿌䝣䜵䝙䝖䝻䝏䜸䞁䠄䝇䝭䝏䜸䞁䠅䝬䝷䝏䜸䞁䠄䝬䝷䝋䞁䠅

䝟䝷䝏䜸䞁

㻰㻰㼀

䝎䜲䜸䜻䝅䞁⎔ቃ䝩䝹䝰䞁ᑐ⟇ᅜẸ఍㆟䝟䞁䝣䜘䜚
http://kokumin-kaigi.org/᭷ᶵሷ⣲⣔௨እ䛿ᅜෆ䛷౑⏝୰䚹⌧ᅾ䚸ẅ⹸๣䛷᭱䜒౑⏝㔞䛜ከ䛔䛾䛿᭷ᶵ䝸䞁⣔䚸ḟ䛔䛷䝛䜸䝙䝁䝏䝜䜲䝗⣔䚹䝣䜵䝙䝹䝡䝷䝌䞊䝹⣔䝛䜸䝙䝁䝏䝜䜲䝗⣔䝢䝺䝇䝻䜲䝗⣔䜹䝹䝞䝯䞊䝖⣔

᭷ᶵ䝸䞁⣔

᭷ᶵሷ⣲⣔

㎰⸆䛾✀㢮

༴㝤䛺ẅ⹸๣䠄㎰⸆䠅䛾ኚ㑄䝛䜸䝙䝁䝏䝜䜲䝗⣔ ⬻Ⓨ㐩䜔⢭Ꮚᙧᡂ䜈䛾ᝏᙳ㡪䜢♧䛩ㄽᩥ䛜ከᩘ䚹
䛣䛾20ᖺ㏆䛟䛷౑⏝㔞䛜ᛴቑ䛧䛶䛔䜛䛾䛷䚸せὀព䟿•ฟ඾䠖䛂Ⓨ㐩㞀ᐖ䛾ཎᅉ䛸Ⓨ⑕䝯䜹䝙䝈䝮䛃㯮⏣ὒ୍㑻䚸ᮌᮧ䞊㯮⏣ඹⴭ 2020ᖺቑ⿵ᨵゞ∧䝛䜸䝙䝁䝏䝜䜲䝗⣔㎰⸆䛾䝅䜾䝘䝹ẘᛶ37

39ẅ⹸๣䛿⬻⚄⤒⣔䜢ᶆⓗ䛻䛧䛶䛔䜛䛾䛷䚸⬻⚄⤒⣔䜢┤᥋᧠஘䞉㜼ᐖ䛩䜛᭷ᶵ䝸䞁䚸䜹䝹䝞䝯䞊䝖䚸䝢䝺䝇䝻䜲䝗䚸䝛䜸䝙䝁䝏䝜䜲䝗䚸䛹䛾ẅ⹸๣䜒⫾ඣᮇ䛻᭚㟢䛩䜛䛸䚸7ṓ䛻䛺䛳䛯Ꮚ䛹䜒䛾IQ䛜᭷ព䛻పୗ䛩䜛䛸Ⓨ⾲䚹

Gunier RB, et al. Environ Health Perspect. 2017, 125:057002. ⡿ᅜ䜹䝸䝣䜷䝹䝙䜰኱䝢䝺䝇䝻䜲䝗⣔ ⬻Ⓨ㐩䜔⢭Ꮚᙧᡂ䜈䛾ᝏᙳ㡪䜢♧䛩ㄽᩥ䛜ቑ䛘䛶䛔䜛⮬㛢⑕䚸ADHDⓎ⑕䛸䛾㛵㐃䚸⢭Ꮚ䛾ῶᑡ→ ᭷ᶵ䝸䞁⣔䛰䛡䛜ཎᅉ䛷䛿䛺䛟䚸௚䛾せᅉ䛜㛵䜟䛳䛶䛔䜛䚹᭷ᶵ䝸䞁⣔㎰⸆䛜⬻Ⓨ㐩䛻ᝏᙳ㡪䜢ཬ䜌䛩䛣䛸䛿ከ䛟䛾◊✲䛛䜙☜ㄆ䛥䜜䛶䛝䛶䛔䜛䛜䚸᪥ᮏ䛾᭷ᶵ䝸䞁౑⏝㔞䛿ῶᑡഴྥ䛺䛾䛻䚸Ⓨ㐩㞀ᐖඣ䛜ቑ䛘䛶䛔䜛䚹

᭷ᶵ䝸䞁⣔
䞁⣔

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•

᭷ᶵ䝸䞁⣔௨እ䛾ẅ⹸๣䛷䜒Ⓨ㐩⚄⤒ẘᛶ䛾ሗ࿌䛜ቑ䛘䛶䛔䜛ಙྕ䝎䜲䜸䜻䝅䞁⎔ቃ䝩䝹䝰䞁ᑐ⟇ᅜẸ఍㆟䝟䞁䝣䜘䜚䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䛿䝍䝞䝁ྵ᭷䛾ẘ≀䝙䝁䝏䞁䛜䜘䛟⤖ྜ䛩䜛䛯䜑䛻࿨ྡ䚹ู䛾✀㢮䛾䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䜒䛒䜛䚹40䜰䝉䝏䝹䝁䝸䞁䛸䝙䝁䝏䞁ᛶཷᐜయ䛿䚸⬻⚄⤒⣔௨እ䛾⤌⧊䠄ච␿⣔䚸ᚠ⎔ჾ⣔䚸⏕Ṫჾ⣔䚸ୖ⓶⣔䛺䛹䠅䛻䜒Ꮡᅾ䛧䛶䛔䜛䛯䜑䚸䝙䝁䝏䞁䜔䝛䜸䝙䝁䛿⬻⚄⤒⣔௨እ䛻䜒ᝏᙳ㡪䜢ཬ䜌䛩ྍ⬟ᛶ䛜㧗䛔䚹䝍䝞䝁䛻ྵ䜎䜜䜛ẘ≀䝙䝁䝏䞁䛿䚸䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䛻⤖ྜ䛧䛶䚸䝙䝉᝟ሗ䜢㏦䛳䛶䚸⬻䛾Ⓨ㐩䜢㜼ᐖ䛩䜛䚹䝙䝁䝏䞁᭚㟢䛿᪩⏘䚸పฟ⏕య㔜䚸ஙඣ✺↛Ṛ⑕ೃ⩌䚸ADHDⓎ⑕䛾䝸䝇䜽䛜㧗䛟䛺䜛䚹䝛䜸䝙䝁䛻䜒ྠᵝ䛾ᙳ㡪䛜ᠱᛕ䛥䜜䜛䚹䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䛿䚸⫾ඣᮇ䛾⬻䛷䛿ᡂே䜘䜚䜒ከ䛟Ꮡᅾ䛧䛶䚸⬻䛾ṇᖖ䛺Ⓨ㐩䚸⚄⤒ᅇ㊰ᙧᡂ䜢ᢸ䛳䛶䛔䜛䚹䝛䜸䝙䝁䝏䝜䜲䝗䛾ᶆⓗ䚸䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䛸䜰䝉䝏䝹䝁䝸䞁䛿䚸ே㛫䛾⬻⚄⤒⣔䛷㔜せ䛰䛜䚸Ⓨ㐩ᮇ䛾⬻䛷䛿䛸䛟䛻㔜せ䛺ാ䛝䜢䛧䛶䛔䜛䚹38᭷ᶵ䝸䞁⣔䛿䚸䜰䝉䝏䝹䝁䝸䞁䛾ศゎ㓝⣲䜢㜼ᐖ䛧䚸䜰䝉䝏䝹䝁䝸䞁䛜䛔䛴䜎䛷䜒⯆ዧస⏝䜢㉳䛣䛩䚹ᙉẘ䛺䜰䝉䝏䝹䝁䝸䞁ศゎ㓝⣲㜼ᐖ๣䛿䝃䝸䞁䝛䜸䝙䝁䝏䝜䜲䝗䜔䝙䝁䝏䞁䛿䚸䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䛻⤖ྜ䛧䛶䝙䝉䞉ಙྕ䜢㏦䜛䝙䝉䞉⚄⤒ఏ㐩≀㉁ཷᐜయ䜔ศゎ㓝⣲䛿᪻⹸䛸䝠䝖䛷㢮ఝ䜰䝉䝏䝹䝁䝸䞁䛿᪻⹸䚸ே䛷
ඹ㏻䛾㔜せ䛺⚄⤒ఏ㐩≀㉁䝛䜸䝙䝁䝏䝜䜲䝗䛜Ꮚ䛹䜒䛻ᝏᙳ㡪䜢ཬ䜌䛩⌮⏤

ಙྕ

䝅䝘䝥䝇

䝘䝖䝸䜴䝮䝏䝱䝛䝹᭷ᶵሷ⣲⣔BHC䜔䝢䝺䝇䝻䜲䝗⣔䛾ᶆⓗ䜰䝉䝏䝹䝁䝸䞁⣔⚄⤒ఏ㐩䜢㜼ᐖ䞉᧠஘䛩䜛䜰䝉䝏䝹䝁䝸䞁⣔⚄⤒ఏ㐩䜢㜼ᐖ᧠஘䝛䜸䝙䝁䝏䝜䜲䝗䛸᭷ᶵ䝸䞁⣔ẅ⹸๣ᢞ୚ᚋ⚄⤒⣽⬊䝬䞊䜹䞊
⚄⤒⣽⬊100 μ䡉

ACE䠗䜰䝉䝍䝭䝥䝸䝗
IMI; 䜲䝭䝎䜽䝻䝥䝸䝗

Kimura-Kuroda
KimuraKuroda et al. PlosOne
P
2012

䝛䜸䝙䝁䝏䝜䜲䝗䛿䝷䝑䝖Ⓨ㐩ᮇ⚄⤒⣽⬊䛻䜸䝙䝁䝏䝜䜲䝗䛿䝷䝑䝖Ⓨ㐩ᮇ⚄⤒⣽⬊䝙䝁䝏䞁ᵝ䛾⯆ዧస⏝䜢㉳䛣䛩ᅜ❧⎔ቃ◊✲ᡤ䝕䞊䝍䝧䞊䝇
41㎰⸆ฟⲴ㔞䜘䜚

䜽䝻䝏䜰䝙䝆䞁

䜰䝉䝍䝭䝥䝸䝗

䜲䝭䝎䜽䝻䝥䝸䝗

䝙䝔䞁䝢䝷䝮

䝏䜰䜽䝻䝥䝸䝗

䝏䜰䝯䝖䜻䝃䝮

䝆䝜䝔䝣䝷䞁

䝇䝹䝩䜻䝃䝣䝻䝹

䝣䝹䝢䝸䝭䞁

䝛䜸䝙䝁䝏䝜䜲䝗⣔ẅ⹸๣→䝛䜸䝙䝁䝏䝜䜲䝗䛿့ங㢮䛻䜒స⏝䛩䜛 Ḣᕞ㣗ရᏳ඲ᶵ㛵䛜䛣䛾ㄽᩥ䜢⢭ᰝ䛧䚸䝛䜸䝙䝁䛻Ⓨ㐩⚄⤒ẘᛶ䛾ྍ⬟ᛶ䛒䜚䛸䛧䛯(2013ᖺ䠅43䝙䝁䝏䞁ᛶ䜰䝉䝏䝹䝁䝸䞁ཷᐜయ䜢Ⓨ⌧䛧䛶䛔䜛Ⓨ㐩ᮇ䛾䝷䝑䝖ᇵ㣴⚄⤒⣽⬊䛿䚸ప⃰ᗘ䠄䠍μM௨ୖ䠅䛾䜰䝉䝍䝭䝥䝸䝗䚸䜲䝭䝎䜽䝻䝥䝸䝗ᢞ୚䛻䜘䜚䝙䝁䝏䞁ᵝ䛾⯆ዧస⏝䜢㉳䛣䛧䛯䚹

0

50

100

150

200

250

300

350

400

450

䝛䜸䝙䝁䛿᪻⹸䛻䛿㧗ẘᛶ䛾䛯䜑⥲౑⏝㔞䛜ῶ䜚䚸ῶ㎰⸆䚸≉ู᱂ᇵ䛸䛧䛶㈍኎
䛥䜜䜛䛣䛸䜒䛒䜛

᭷ᶵ᭷ᶵ䝸䞁⣔䛾౑⏝㔞䛿ẅ⹸๣䛾䛺䛛䛷䛿䛔䜎䛰䛻୍␒ከ䛔䛜ῶᑡഴྥ⣔ ౑ 㔞 ẅ⹸๣ 䛺䜎䛰␒ከ 䛜ῶᑡ

ᢞ୚๓

䝖䞁

500

䝙䝁䝏䞁

䜰䝉䝍䝭䝥䝸䝗

䜲䝭䝎䜽䝻䝥䝸䝗

㻝㻥㻥㻜㻥㻜ᖺ௦䛛䜙ᛴቑ䛧䛯䝛䜸䝙䝁䝏䝜䜲䝗

Relative Ca2+ influxᑐ↷⩌ ప⏝㔞 㧗⏝㔞᭚㟢᭚㟢Ꮫᰯ⤥㣗䛻↓㎰⸆䞉᭷ᶵ㎰⏘≀䜢౑䛖䜘䛖ാ䛝䛛䛡䜛䚹䜸䞊䜺䝙䝑䜽⤥㣗䝬䝑䝥•䝥䝷䝇䝏䝑䜽〇ရ䛿⇕䜔Ἔ⬡䛷⎔ቃ䝩䝹䝰䞁䛜ฟ䛶䛟䜛ྍ⬟ᛶ᭷䚹㟁Ꮚ䝺䞁䝆ྍ䛷䜒䜺䝷䝇䜔䛫䛸䜒䛾䛷䚹䝥䝷䝇䝏䝑䜽䝣䝸䞊䛾⏕ά䜢┠ᣦ䛭䛖䚹᭷ᶵ䝣䝑⣲ຍᕤ〇ရ䛾౑⏝䛿Ṇ䜑䜛䚹䝣䝑⣲ຍᕤ䛾䝣䝷䜲䝟䞁䜔㜵Ỉ〇ရ䛺䛹Ỉ㖟䛺䛹㔜㔠ᒓ䜢㑊䛡䜛䠖Ỉ㖟䛿䝬䜾䝻䛺䛹䛾㨶䛻ከ䛔 ཌປ┬䜘䜚䝟䞁䝣᭷

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PCB䚸䝎䜲䜸䜻䝅䞁䜢㑊䛡䜛䠖⏕ែ⣔ୖ఩䛾㨶䜔⫗䛾⬡䠄䜽䝆䝷䚸䝬䜾䝻䛾䝖䝻䛺䛹䠅኱Ẽởᰁ䜢㑊䛡䜛 PM2.5, 䝬䜲䜽䝻䝥䝷䝇䝏䝑䜽䚸䝘䝜䝥䝷䝇䝏䝑䜽䛿༴㝤䚹ᨺᑕᛶ≀㉁䜔Ⓨ䛜䜣ᛶ䛾䛒䜛໬Ꮫ≀㉁䛻䜒ὀព䚹䛯䛟䛥䜣䛒䜚䜎䛩䛜䚸䛒䜎䜚⚄⤒㉁䛻䛺䜙䛪䛻䚸䛷䛝䜛䛣䛸䛛䜙䜔䜚䜎䛧䜗䛖䚹

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ᢠ⳦๣䚸ẅ⳦๣䚸ᾘ⮯๣䛾஘⏝䜢㑊䛡䜛䚹ᢠ⏕๣䛾஘⏝䛻䜒ὀព䚹

•https://www.mhlw.go.jp/topics/bukyoku/iyaku/syoku-anzen/suigin/dl/100601-1.pdf
䜰䝹䝭㘠䛿㓟ᛶ㣗ရ䛷⚄⤒ẘᛶ䜢䜒䛴䜰䝹䝭䜲䜸䞁䛜⁐ฟ䛩䜛䛾䛷㑊䛡䜘䛖䚹ᐙᗞ⏝䞉ᅬⱁ⏝ẅ⹸๣䚸㝖ⲡ๣䜢౑䜟䛺䛔䚹Ꮚ䛹䜒䛻䛿≉䛻ὀព

•https://organic-lunch-map.studio.site/home㎰⏘≀䛿䛺䜛䜉䛟↓㎰⸆䚸᭷ᶵ㎰⏘≀䜢㑅䜃䚸㣗ရῧຍ≀䜒䛷䛝䜛䛰䛡㑊䛡䜛䚹•䠓䠊᭷ᐖ໬Ꮫ≀㉁䛛䜙Ꮚ䛹䜒䜢Ᏺ䜛䛯䜑䛻

42

䝠䝖䛾Ⓨ㐩㞀ᐖ䛾୍㒊䛿䝛䜸䝙䝁䝏䝜䜲䝗᭚㟢䛥䜜䛯㞝௘䝬䜴䝇䛷෌⌧䛥䜜䛶䛔䜛ྍ⬟ᛶ• 䝠䝖䛷䛿⮬㛢⑕䛺䛹Ⓨ㐩㞀ᐖ䛿⏨Ꮚ䛻ከ䛟䚸≉ᐃ䛾⾜ື䛾䜏␗ᖖ䛜䜏䜙䜜䜛䚹• ௘䝬䜴䝇⬻ෆ䛛䜙䜰䝉䝍䝭䝥䝸䝗䛜᳨ฟ䛥䜜䚸ẕ⫾䛛䜙௘䛾⬻䛻⛣⾜䛜☜ㄆ䛥䜜䛯䚹ᢞ୚䛩䜛䛸㞝௘䝬䜴䝇䛷୙Ᏻ⾜ື䚸ᨷᧁ⾜ື䚸ᛶ⾜ື䛺䛹䛻䚸␗ᖖ⾜ື䛜䜏䜙䜜䛯䚹㎰⸆ẘᛶヨ㦂䛷↓ẘᛶ㔞䛿7.1mg/kg䛺䛾䛷䚸↓↓ẘᛶ㔞௨ୗ䛷␗ᖖ䛜☜ㄆ䛥䜜䛯䚹• ẕ䝬䜴䝇䛻⤒ཱྀᢞ୚䛷䜰䝉䝍䝭䝥䝸䝗䜢1, 10mg/kgయ㔜/᪥䚸⫾௘ᮇ䡚ᤵஙᮇ䛻ᅜ❧⎔ቃ◊✲ᡤ Sano K et al. Front Neurosci. 2016 Volume 10

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㞝௘䝬䜴䝇䛾୙Ᏻ⾜ື⫾௘ᮇ䚸ᤵஙᮇ䛻䜰䝉䝍䝭䝥䝸䝗䜢ప⏝㔞㛗ᮇ᭚㟢䛧䛯㞝௘䝬䜴䝇䛻␗ᖖ⾜ື⎔ቃ⬻⚄⤒⛉Ꮫ᝟ሗ䝉䞁䝍䞊HP https://environmental-neuroscience.info/㎰⸆䜾䝸䝩䝃䞊䝖䜔䝛䜸䝙䝁䝏䝜䜲䝗䚸⎔ቃ䝩䝹䝰䞁䛺䛹䛻䛴䛔䛶䚸᝟ሗᥦ౪䚹᪥ᮏㄒ䛾⥲ㄝ䠄䜾䝸䝩䝃䞊䝖䚸䝛䜸䝙䝁䠅䛺䛹䝣䝸䞊䝎䜴䞁䝻䞊䝗䛷䛝䜛䜒䛾䜒ᥖ㍕• ಶே䝺䝧䝹䛷᭷ᐖ䛺໬Ꮫ≀㉁䛾᭚㟢䜢㑊䛡䜛ᑐ⟇䜢䛸䜝䛖• Ꮚ䛹䜒䜿䝭䝛䝑䝖䛸ඹ䛻䚸ᾘ㈝⪅ᅋయ䚸⏕༠䜔⎔ቃ㻺㻼㻻䛺䛹䛸㐃ᦠ䛧䛶䚸㎰⸆䜔᭷ᐖ໬Ꮫ≀㉁䛾つไᙉ໬䚸ἲつไ䛾ᩚഛ䛺䛹䜢㐍
䜑䜘䛖䚹

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䛄Ⓨ㐩㞀ᐖ䛾ཎᅉ䛸Ⓨ⑕䝯䜹䝙䝈䝮䛅ඹⴭ䚸Ἑฟ᭩ᡣ᪂♫䚸20142020ᖺᨵゞ∧Ⓨ኎୰

45䛄ᆅ⌫䜢⬣䛛䛩໬Ꮫ≀㉁䛅
ᾏ㬆♫䚸2018

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䛤Ύ⫈䚸᭷㞴䛖䛤䛦䛔䜎䛧䛯䚹௨ୗ䜒ᚚぴ䛟䛰䛥䛔䚹• ண㜵ཎ๎䛜㔜せ䠖⬻䛾Ⓨ㐩䛾䝯䜹䝙䝈䝮䛿᭱ඛ➃䛾་Ꮫ䛷䜒䜎䛰ᮍ▱䛾䛣䛸䛜ከ䛔䚹༴䛺䛔䛣䛸䛜ศ䛳䛯ẁ㝵䛷༴㝤䜢㑊䛡䜛䛣䛸䛜኱ษ䚹ᚋ䛻䛺䛳䛶䚸ྲྀ䜚㏉䛧䛜䛴䛛䛺䛟䛺䜛• Ⓨ㐩㞀ᐖᛴቑ䛾ཎᅉ䛸䛧䛶䚸㎰⸆䜔⎔ቃ䝩䝹䝰䞁䛺䛹᭷ᐖ䛺⎔ቃ໬Ꮫ≀㉁䛾ᝏᙳ㡪䛻䛴䛔䛶䚸⛉Ꮫⓗ஦ᐇ䛜⵳✚䛧䛶䛔䜛䚹ᐇ㝿䛻䛿」㞧䛺」ྜᙳ㡪䛜㉳䛣䛳䛶䛚䜚䚸ヲ⣽䛺⛉Ꮫⓗ䛺ゎ᫂䛿᫬㛫䛜䛛䛛䜛䚹

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