CONFIDENTIAL

3H Medi Solution
Patient Insight Capabilities

Seikatsu Kojo Website

l Japan's largest healthcare
information and monitoring
information website
l 840,000 member databases thatwould like to participate inmonitors
l More than 200 diseasecategories
l More than 100,000 clinical datal More than 150,000 dosing
informationl More than 10,000 monitor
referrals per year
l Able to make disease awarenessads and advertise clinical trials● Steering Company 3H Clinical Trials K.K.
● Media Name ”Seikatsu Kojo Web"□URL http://www.seikatsu-kojo.jp/● Ratio of male to female: 1:1□ Monthly PV count 2 million PVs● Number of monthly visitors 300,000● 10,000 patients enrolled per month

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2

Database(880,000 Patients)

94,000 people

138,000 people

71,000 people

35,000 people

73,500 people

1,800 people

14,300 people

26,000 people

38,500 people

102,000 people

15,200 people

8,800 people

18,000 people

880,000 people

14,900 people

6,800 people

5,300 people

694,000 people

Registered different conditions
Registered conditionsDisease by categoriesv

Database(880,000 Patients)
Registered Conditions TOP50
RANK

Disease Name

# Registered

RANK

1

Hypertension

37,681

2

Seasonal Allergy

33,7753Hyperlipidemia

4

Allergic Rhinitis

5

Disease Name

# Registered

26

Appendicitis

2,700

27

Iron-deficient Anemia

2,654

27,20228

Allergic Conjunctivitis

2,602

19,68629

Sinusitis

2,527

Insomnia

15,14530

Endometriosis

2,470

6

Depression

13,65931

Chronic Urticaria

2,463

7

Bronchitis

12,84632

Dysmenorrhea

2,392

8

Atopic Dermatitis

12,04333

Glaucoma

2,091

9

Acne

11,45634Type I Diabetes

2,086

10

Type II Diabetes

9,679

35

Panic Attack

1,910

11

Uricemia (Gout)

9,237

36

BPH

1,709

12

Venous Thrombosis

9,151

37

Angina Pectoris

1,632

13

Tinea Pedis

7,967

38

IBS

1,611

14

Back Pain

6,371

39

Schizophrenia

1,563

15

Dry Eye

5,880

40

Carpal Tunnel

1,516

16

Constipation

5,757

41

Rheumatoid Arthritis

9,447

17

Hypertriglyceridemia

5,568

42

Menopause

1,374

18

Uterine Fibroids

4,554

43

Cataracts

1,342

19

Peptic Ulcer

4,355

44

Chronic Gastritis

1,325

Myocardial Infarction

1,194Pneumonia

1,165

20

Overactive Bladder

4,277

4521

GERD

4,225

46

22

Osteoporosis

4,195

47

Arrhythmia

1,105

Dysautonomia

997

23

Alzheimer

4,011

48

24

Shingles

3,698

49

Joint Deformation

974

25

Duodenal ulcer

3,071

50

Seborhheic Dermatitis

939

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Membership information data in possession
Item

Contents

Hematology parameters
WBC count

Total Bilirubin

Uric acidRed blood cellcount

AST(GOT)】

Nitrogen urate

Age/SexMale/female age

Address

National prefectures/national municipalities

Date of birth

Day of birth

Hemoglobin
content

ALT(GPT)】Creatinine

Height/Weight/BMI

Height (cm)/Weight (kg)Hematocrit

ALPNa

Date of completion

Date Month YearMCVLDHK

Occupation

Students, company officers, officials, civil servants, self-employed, nonemployed, freeters, housewives, etc.

MCH

y-GT

CI

Drinking/Smoking

Drinking (yes/no) Smoking (yes/no)

MCHC

CPK

LDL cholesterol

Desired information

Clinical trials, beauty care, cosmetics and health foods

Platelet countHemoglobin A 1 C

Desired guidance
methodTelephone, e-mail, fax, and direct mailFasting plasmaglucoseTPTotal cholesterol

Systolic blood pressure (top)Desired contact time

Weekdays, Saturdays, Sundays, and Hours

A/GHDL-Cho

Medical information

Disease information, blood test data, medication information, etc.

Diastolic blood pressure(bottom)

ALB

TriglycerideTime of data extraction

Area

Disease name * All disease categories are more than 300

Endocrine metabolicdisease

Type 1 diabetes mellitus, type 2 diabetes mellitus, suspected diabetes mellitus, obesity, hyperuricemia, hypercholesterolemia, pediatric, etc.

CardiovasculardiseaseHypertension, atrial fibrillation, angina pectoris, heart failure, venous thrombosis, etc.

Digestive disorder

Ulcerative colitis, reflux esophagitis, gastric ulcer, Crohn's disease, irritable bowel syndrome, taste disorder, etc.

Respiratory disease

Bronchial asthma, pneumonitis, chronic obstructive pulmonary disease, respiratory infection, COPD, pediatric, etc.

Orthopedic disease

Low back pain, osteoporosis, rheumatoid arthritis, osteoarthritis of the knee, etc.

Neurologic disorders

Sleep disorder, sleep apnea syndrome, Alzheimer's dementia, other dementia, Parkinson's disease, Restless syndrome, cerebral infarction, pediatric,etc.

Psychiatric disorders

Schizophrenia, depression, social-anxiety disorder, anorexia, PTDs, panic disorder, epilepsy, bipolar disorder, pediatric, etc.

Renal, hepatic, andbiliary diseases

Renal impairment, hepatitis B/C, tumor, cirrhosis, liver dysfunction, etc.

Skin disease

Acne vulgaris, psoriasis vulgaris, atopic dermatitis, chronic urticaria, tinea unguium, herpes zoster, seborrheic dermatitis, pediatric, etc.

Patient InsightCollection of patient voices from our 856,000 database members using: internet, contact center, mailsurveys, face-to-face, communities…etc., Segmented data relating to diseases, lab stats, drug
administration are also attainable.

Internet Research
Phone Research

Member hearing conducted nationwide byspecialized communicators

856,000members>583 disease categoriesl Disease datal Laboratory data

150,000l Drug use data

350,000v

Most suited towards elderly members
Original copy of survey can be kept for records

Community Research

Best method for observational day-to-day records
such as patient occasion and disease status

Depth Interview

For hearing the patient's real voice which may besometimes difficult with surveys (insight research)

Group Interview

Conduct insight research efficiently through opendiscussion forums with patients

Copyright © 3H medi solution

Qualitative
Research250,000

Mail Research

Quantitative
ResearchOn patients with specific diseases is possible evenwith a low budget over a short period

6Clinical Research Solutions
Planning

DrugdesignDevelopment
PhaseⅠ〜Ⅲ

Market launch

Post-market

Ⅰ.Patient insight/PRO（Patient Reported Outcome)Protocol design

Areas of support︓
POC creation, protocol design, trial planning, DTC marketing, Patient-centred drug development

Ⅱ.Clinical research（Casestudies/surveys)

Site selection

Areas of support︓
Protocol design, research/survey planning, post-market evidence construction(expanded indication, safety, etc.)

Patientrecruitment

Research/Survey

Report/Journal
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Ⅲ.Clinical trial (Prevention, diagnosis,treatment, care)

Areas of support︓
Post-market evidence construction (expanded indication, safety, etc.)
PRO from RWD

Ⅳ.Patient support program（compliance/adherence）

Areas of support︓
Activities raising patient compliance & adherence, patient retention
7Marketing Services Overview
Analysis through PX（Patient Experience）

Trial
recruitment
data
Quantitative
Data

Site visit
action/drug
use data

Trialadvertisement
response data

PX Management Design

SWS（Strategy Workshop）

DTC Strategies

PX
PatientExperience

QOL data

Qualitative
Data

Variousresearch data

Patient insightCommunication DesignDirect

TargetingSegmentation

薬局
メルマガ

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疾患啓発サイト8

Patient Insight Research
Online survey

Mobile behavior observation

Compatible with most devices

Observe patient behavior through app
installed on 3Hʼs C-Phone device（MROC）
Members with the same healthcondition converse on online forum

Patient journeySocial media analysis

Digital diaryDiet, lifestyle, medication intake,health status, etc. are recordedv

Visualize patient action/feelings:
Disease onset→Hospital→Diagnosis→Prescription→Medication

Copyright © 3H medi solution

Online forum

Extract disease and health information
through social media and analyze

9Our Experiences: Past and current studies
ClientDiseasen=Method

Year

Global CRO

Type II DM

Pilot: 40
Main: 160

Interview +Web survey

2015

Global Pharmaceutical
Company

NSCLC

Online survey: 160
Interview: 10

Interview +Web survey

2016Japanese PharmaceuticalCompanyCNS patients

1,400

Phone Interview

2016

Global CRO

Uterine fibroid

External panel: 200
Seikatsu Kojo panel:
1,616

Web survey

2017Japanese Pharmaceutical
Company

Rheumatoid arthritis

MROC: 20
IDI: 5

MROC + Phone IDI

2017

Global CRO

Type II DM

Interview: 10
Web survey: 190

F2F Interview +Web survey

2018

Global Pharmaceutical
Company

Psoriasis

MROC: 50
IDI: 18

MROC + IDI

On Going

Global Pharmaceutical
Company

Acne patient survey

MROC: 300

MROC

On Going

Global Pharmaceutical
Company

Prostate cancer patient
qualitative survey

Qualitative: 10

F2F Interview

2018/2019

Global PharmaceuticalCompany

Lung cancer patients
quantitative survey

Quant: 100

Web Survey

2018/2019

STRICTLY PRIVATE AND CONFIDENTIAL Copyright 2018. 3H Inc.

Past and Current Studies (Patient Survey)
SampleSize

MethodDate

300s

WEB Survey

2018

Interview survey to grasp the Patient Journey
Map as well as on intent to use drug during
development.

16s

Qualitativeinterview(IDI)

2018

Quantitative survey ofcancer patient

Quantitative survey on the actual conditionand consultation of pain and anxiety forcancer patients and consultation partners.

300s

WEB Survey

2018-19

Qualitative survey ofProstate cancer

Interview survey on communication withmedical staff on fatigue / malaise during
treatment.

10s

Qualitativeinterview(Tel)2018-19

Quantitative researchof Lung Cancer
Patients

Quantitative survey on IC contents, selection
factors, IC satisfaction level etc. in drug
selection of lung cancer patients

100s

WEB Survey

2018-19

Acne Patients Survey

Quantitative Survey for concerning troubles
and countermeasures for patients with mild
acne (Reasons to visits / non-visits thehospital)

300s

MROC

2019

50s

MROC

2019

Quant:100s
Quality: 5s

WEB Survey
(IDI)

2019

ClientResearch ThemeDomestic
PharmaQuantitative Researchof Ulcerative Colitis
Patients

Quantitative survey on selection andacceptability of treatment methods for thepatients with ulcerative colitis.

Patient survey of OA(knee) · CLBP (lowback pain)

GlobalPharmaGlobalPharmaGlobalPharmaGlobalPharmaGlobalPharmaDomestic
PharmaDomestic
Pharmav

Survey Contents

Anaemia Patient
SurveySurvey to grasp the benefits of new drugs vscurrent therapies targeting Anaemia patients

Anaemia Patient
SurveyClinical CS survey for patients with Anaemia
Copyright © 3H111Patient Insight //Cancer treatment patients
Project Summary //SponsorGlobal Pharma

Support from 3H

Quantitative Research

Timing ofconsultation

Considering Disease AwarenessTargetOngoing treatment Cancer Patients# of sample

n=287(BC,LC,CML,RCC)

Target area

All Japan

Medias used

OncoloImpressive Number //Expert Analysis //üüüü

There are patients who can not consult their doctor about
their pain and anxiety.
Patients usually get the care/treatment after consultation
but there are the cases where care/treatment was notprovided as well as even after receiving there was not
improvement some said. So it is necessary to improve thecurrent situation.
After consultation 80% of patients were satisfied however
solving the pain & anxiety was key points
By communicating to doctor about their pain and anxiety toand getting the appropriate care which resulted in
acceptance of longer duration of cancer treatment.

v

90Japanese Cancer Patients were interviewed
to know about their pain and their caregiving condition whether it is sufficient or not.
Those who felt uneasy even once was 89.9%, wheremost of them had an anxiety experience. In addition,
65.5% answered that they felt pain even once, andthose who had pain during cancer treatments were over60%.
There were more than half of patients who answeredthat “pain” and “anxiety” were affecting their cancer
treatment. Further, half of total patient answered thatthey have consulted their doctors about pain where only
20% of patients replied that they have consulted to theirdoctors for anxiety. However 41.7% replied that they
had not got care after consulted with doctor about theiranxiety.

Copyright © 3H

12Patient Insights //OA/CLBP
Project Summary //3H Support

In-Depth-Interview(Qualitative)

Timing of consultation Pre Product Launch
TargetKnee OA, Back Pain CLBP

# of sample

n=12 (OA=6, CLBP=6)

Target Area

All JapanTactics

DBImpressive Number

4

Expert Analysis//
There was four main situation where pain put a great impact
on work and in daily life. The most affected group was physicallabour as well as nursing care service people who carry elderly
people by a car or transporting the luggage through truck. The
second is daily routine work such as getting up in the morningand going to washbasin with bended waist which put an affectin daily life. Next it was affecting in doing the housework,
childcare, hobby and sports.
Further, condition forced them to change their occupations
as well as they were continuously feeling pain and fatigue
in various actions on a daily basis, which was also
resulting in anxiety of becoming impossible to walk in thefuture.

v

Challenges. New drugs (Phase 3 completed:
NDA under process) being developed by pharmaceuticalcompany, this drug is based on new mechanism to preventthe pain. In order to make the launch successful in Japan,
sponsor wanted to get some clue to construct the message
for the patient through this interview.
Are OA/CLBP Patients having any trouble in treatment
currently. And if they have some problem then what istheir issue. Whether this new drug can provide thesolution of the problem of the patient or not. It was thetarget of this Interview.
Research Objective
・History of the intensity of pain from onset to the present
・In the history of treatment for the pain, what was theissue and what they wanted to have.
・Evaluating the concept of the new drugs

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Thank you
To know more please contact:

imran@3h-ms.co.jp