2021 ReportSocial andEnvironmental
ImpactCell Signaling Technology is a
global company of caring people
driven by a devotion to facilitating
good science—a company
committed to doing the right thingfor our customers, our communities,
and our planet.

Cover: Corporate Partner Seeding Labs
Highlight Chantal Atchie, Dedeou
Tchokponhoue, and Kenou Adonon
are observing miracle berry fruits
growing in the experimental fields at
the university.
Photo: courtesy Université d’Abomey-Calavi/
Seeding Labs

2

Photo: Josh Pelta-Heller, CST US Sales TeamA Letter from Michael Comb
For the first time since life has evolved, our planet’s natural systems are outof balance due to one species’ ability to dominate and determine what
future life will look like. Science can provide answers to some of thequestions we seek but our future will ultimately be determined by politicaland social will. As a citizen, and CEO of a private, family-owned biotech
company, I recognize my responsibility and place in a much larger world
economy that connects us and our actions to the health of the planet.
The path we are currently following is not sustainable. We need to makechanges in the way we operate as companies and as individuals.
CST continues its transition to become a more sustainable and innovative
company that will create positive change. We are rethinking the way we use
energy to stop burning fossil fuels that emit greenhouse gases and arefocused on how to use less water and generate less waste. If we can move
to more circular economies that reuse what is produced, we can allow
enough space for the rest of the planet’s amazing biodiversity to thrive. We
must show more respect and compassion for other life forms on the planetby preserving needed wild space. Our new partnership with 1% for thePlanet will reinforce our mission and align with our values.
For nearly a half century, Sir David Attenborough has inspired me tocelebrate the Earth’s natural systems and the incredible life and functions
they support. I couldn’t agree more with his sentiment:“The truth is: the natural world is changing. And we are totally dependent
on that world. It provides our food, water, and air. It is the most precious
thing we have, and we need to defend it.”Businesses must be more responsible and work in partnership with eachother and our communities to foster inclusion and respect. The impact ofhuman society on the natural world is evident. As a grandfather, scientist,businessman, and member of humanity, combating climate change and theloss of biodiversity is the most pressing challenge for my generationand future generations that follow.

Michael J. Comb, PhD,
President and Chief Executive Officer“The path we are
currently following is
not sustainable.
We need to makechanges in the way
we operate ascompanies and as
individuals. ”
3
Photo: Tristan Comb

Measuring Impact
The business of antibodies at Cell Signaling Technology has always

been about advancing science, first and foremost. Do researchers have the tools they need to
get the answers they pursue? That simple question started a business that thrives today. Eachdollar earned is an opportunity to reinvest, to learn more about the scientists in the field, theirneeds, and the challenges that they face every day. Each discovery made becomes knowledge
that benefits all.
Once you start thinking that big, it’s difficult to scale back. You start looking for new ways
to make the world better. How can we help fight climate change? How can we give back tocommunities near and far, scientific or otherwise? Beyond our research tools, what else can we
give?
These questions aren’t easily answered, but the most important thing is to do good. American
poet Maya Angelou said, “Do the best you can until you know better. Then when you know
better, do better.” We want to do better. One tenet we’ve lived since the beginning is the idea ofContinuous Improvement. Take what you can do today and make it better tomorrow.
Small enhancements can yield big results, but you can’t improve something that you don’t
understand. Improvement requires honest self-examination and data. We have prioritized oursocial and environmental impact areas into three pillars:• Innovation & Operations• Culture & Community• Planet & Health

It feels a bit strange to try to quantify our efforts to impact our business and the world aroundus. The past two years have given the added challenge of pivoting to necessary COVID-19related efforts. However, we also feel it’s important to be accountable. Are we doing what we
set out to do? How are we effecting positive change? This report is a way for us to paint the
picture in broad strokes. It’s a way for us to collect and focus our efforts, to make sure that next
year we do a little better.

“Do the best you
can until you know
better. Then when
you know better,
do better.”–Maya Angelou

Front entrance of CST Headquarters in
Danvers, MA

4

COVID-19 Pandemic Response
We worked to keep our employees, our families, and ourcommunity safe. Early in the pandemic it became clear that a measured
approach, backed by data and CDC guidance, would be the best pathto safety. We ramped down non-critical operations, while continuously
working on COVID-related development projects. There was no disruption
in shipping or supporting our Customers, who continued to performessential research to understand the virus.
Upon returning, CST employees met new challenges with vigor. Not only
did they perform their usual jobs, but did so with fewer people onsite,
learning new roles, and working around the clock to create a safe andflexible work environment to protect and support CST families. Everyone
was tremendously careful to protect each other.
We added employee benefits:• Health and wellness services• COVID testing onsite and at contracted clinics• Increased cleaning services at our facilities• Barriers, masks, other safety precautions at U.S. labs and global shipping
facilities.
• Flexible work-from-home policy• Seminars to help with mental health, child care, anxiety, and otherimpacts of the pandemic• IT equipment and ergonomic support for work-from-home employees

Staying connected was a priority.
The COVID Response Team communicated weekly with all employeeson the state of the pandemic and how it affected our business and our
employees’ welfare. We became virtually connected, creating linkages not
only on a business level, but personally to check on each other.

This was a global pandemic and it brought us
together as a global company.
We were informed by employees in our China office in January 2020 ofwhat was happening in Wuhan. They requested PPE for their crisis, and we
responded immediately. Later in the year, they would return the favor as thesituation worsened in the US. It was a reminder that all our global offices
worked through this together—supporting each other however we could
along the way.

Early efforts
by CST China tounderstand thevirus enabled us
to identify ACE2
and other potential
SARS-CoV-2
research targets
to be added to the
product development pipeline
immediately.
It was vital toprovide usefultools to scientists
researching thevirus as quickly as
possible.

As our U.S. facilities were temporarily
shutting down, CST immediately
donated nearly $10K worth of PPE toa local hospital desperately in need.

5Innovation & Operations
We are a company of scientists working for scientists. We understand how frustrating it
is to use tools that don’t work. Each experiment ought to be a success, even if the resulting dataaren’t what you predicted. Validation data and knowledge sharing help deliver discoveries andpromote advancements that benefit all.
Delivering expert scientific collaboration is a foundational part of who we are and what we do.
Can all that important work be made more sustainable? Are we acting responsibly with our
product development and production processes? Is each employee set up for success in thesafest possible work environment? These are the questions that drive this impact pillar.

Scientific Seminars
Expertise fades if it isn’t nurtured. It’s important to keep our development goals aligned withall of the latest advancements and discoveries in the field. Our mission is to develop the tools
researchers need, and this is one of the ways we calibrate our efforts with theirs. These aresome of the speaker highlights over the last few years.
• Dr. Lisa Coussens: Evaluating Myeloid Targets to Enhance Anti-Tumor Immune Responses in 		
Solid Tumors (2019)• Dr. Cigall Kadoch: Structure and Function of Mammalian SWI/SNF Chromatin Remodeling 		Complexes in Human Disease (2018)• Dr. Reuben Shaw:• AMPK and ULK1: Guardians of Metabolism and Mitochondira (2018)• The LBK1-AMPK Pathway: from Lung Cancer Immunotherapy to Parkinson’s Disease (2019)• New Unexpected Targets: AMPK Family Kinases That Suppress Lung Cancer and Restore
Metabolic Balance (2021)• Dr. Li-Huei Tsai: Non-invasive Sensory Stimulation to Induce Gamma Entrainment and Neuro		
protection (2021)

Between 2018 and 2021,
CST hosted over 60 invited
scientific speakers, from allover the world.

Left to right from top: Dr. Lisa Coussens
Dr. Cigall Kadoch, Dr. Reuben Shaw,
Dr. Li-Huei TsaiA History of Impact

1999

2000

• Founded• Recycle /Waste Reduction
Program begins• CST’s first catalog andannual nature calendar

6

Scientific Publications
CST products have earned 105,886 total citations with 49,520 citations
since 2018. Seven of the top ten most-cited antibodies in 2021 were from
CST. CST-authored YAP vs. TAZ: differences in expression revealed throughrigorous validation of target-specific monoclonal antibodies was awarded
Best Paper by the National Society for Histotechnology. Authors: Crosby,
Wood, Simendinger, Grange, Carr, Costa-Grant, Roller, Polakiewicz

Internships
Many of us have been lucky enough to be mentored by someone in ourlives — and we believe it is our responsibility to provide opportunities forhands-on internships to future scientists. Student interns at CST are pairedwith mentors in multiple areas of scientific discovery and business,
including R&D, Production, Marketing, and Information Technology
departments. Many of the student interns are invited to continue theirinternship for consecutive years. After completing their degrees, several
interns have returned as full-time employees.

While employed at
CST, our scientists
have authored or
co-authored nearly
160 peer-reviewed
articles since 1999,
and 55 since 2018.

In 2018-19, we hosted 80 interns with a program investment of $375K.
• Six of the interns have become full-time CST employees since finishing
their degrees.
• The internship program was paused for 2020-21 for COVID safety, but
returned in 2022.

A summer intern and her proud mentor
at the annual Internship Poster Session
held to display interns’ projects andhelp them earn valuable experience
presenting their work

2001
• Formation of Green 		Committee• Summer internprogram begins

2002• Formation of Corporate
Donations Committee

2003• Plight of the Pollinators
catalog7

Resource Conservation Programs
CST provides composting and single-stream recycling at all US facilities.
We have lab-specific recycling programs for EPS foam, pipette tip boxes
and amber glass bottles. The facilities team at the Danvers headquarters
is able to reuse waste water from our reverse osmosis deionized (RODI)
system for onsite irrigation.

Green ChemistryLabs at CST have reduced or eliminated the use of hazardous chemicals
like formaldehyde and dimethylformamide through process changes andthe utilization of less hazardous alternatives.

Equipment Reuse
Retired equipment is donated to scientists-in-need through programs likethose of Seeding Labs, giving it a second life for research. From 2018-2021,
a total of $16K worth of equipment was donated, including essential items
like electrophoresis equipment, water baths, vacuum pumps, thermocyclers, microscope accessories, freezers, and incubators.

Photo: courtesy of University of Namibia/
Seeding Labs

Pharmacy Technician students at
the University of Namibia School of
Pharmacy unpacking equipment
provided by Seeding Labs’ Instrumental
Access program2005• Shift to a 100% Post Consumer 		
Waste shipping envelope

8

CST ships all cold
products in thermal
packaging thatis completely
recyclable, withinsulation madefrom paper fibers
and lined withpaper. There is nouse of EPS foam
for shipping by any
CST facility.

2005• Switch to shipping someproducts and antibodies atroom temperature, reducing 		cold temp packaging andshipping materials

Culture & Community
Community is a funny thing. It exists on the smallest of scales but extends theworld over. All workers in a company share a culture, with subcultures in each group anddepartment. It’s important to us that we do good equally. How can we help each other within
the company? How can we help those around us, near and far?
So many things contribute to a rich and vibrant culture: the arts and humanities, giving andactivism, how we celebrate accomplishments and recognize excellence. Perhaps the mostimportant component is how we help each other when we see a need.
As individuals, we give back through employee volunteer work. Because there are so many
deserving volunteering organizations, CST partners with several non-profits to make sure that
we do good for those with the greatest need. It’s sometimes a struggle knowing you can’t help
everyone, but it’s deeply satisfying to help those we can.
We strive to build employee engagement to foster a positive work culture and an inclusivecompany community through Corporate Partnerships, Volunteering, and Giving, to engage our
employees in good citizenship and work/life balance.
We focus on the following areas to give back to our communities:• Inspiring the Next Generation of Scientists• Protecting the Environment• Community Support: Helping the Underserved and Supporting the Arts

Scholarships(U.S., Japan),$240K

Corporate
Partners

Education
in Science$371K

Environmental
Grants$367K

CST grant committees are
employee-run, with members
rotating every 2 years.

$240K

Community
Grants$394K

2018-2021 Annual Philanthropy
Categories and amounts

Photo: Sarah Klein, Group Leader, Multiplex Assay Development

2006

2006

• Relocate to 3 Trask
Lane, Danvers, MA• Renovate King’s Grant
Hotel into Trask Lane
LEED Certified biotech
facility• Art Gallery and Art Program
to support local artists started

9Corporate Partnerships
What makes a good Corporate Partner? We continuously look for ways tostrengthen our alignment with organizations that encourage science andenvironmental education, art enrichment, and support for theunderprivileged throughout our local communities.
Our Corporate Partnership Program identifies non-profit organizations
that demonstrate missions, visions, and values with which we feel aligned.

Volunteering
From 2018-2021 CST employees donated over 5,700 volunteer hours to
local nonprofits. Volunteer participation has been as high as 71% of U.S.
employees. Almost 200 nonprofits have benefitted from employee timeand effort.

Inspiring the Next Generation of Scientists
Education in Science Grants

These resources help make small dreams a reality at local schools andBetween 2018-2021, organizations. Teachers submit applications describing their unique needs
explaining how CST can help. During 2018-2021, 11 local high schools,
CST provided science and6 middle schools, 11 elementary schools, 13 STEM-focused nonprofits forteachers $317,846
K-12, and 2 clubs (Scouts and Girl Scouts) were awarded grants from CST.
in 64 grants to 43
Scholarships
different schools and Science
Scientific endeavor is instrumental in solving social, environmental, andtechnical challenges that societies face worldwide. We support schools inorganizations.
our community to inspire young people to choose a career committed toscience.
Our goal is to encourage and support students with an interest in STEM
by providing financial security during their college years with a $10K
scholarship.
Students of color are underrepresented in STEM programs and courses
compared to their overall college enrollment rate. There is racial
imbalance amongst STEM majors, evidenced by the fact that only 7.6
percent of all STEM bachelor’s degrees were obtained by students of color
in recent years. To help drive diversity and innovation, CST added four
additional $10K scholarships available to high school senior students ofcolor in Essex County, Massachusetts that are accepted and enrolled inundergraduate STEM-related majors.
Employee volunteers serve organizations to help promote scienceeducation, and CST is proud to provide financial support.

10

2007

2009

• Environmental speakerprogram begins• CSR Program formally
begins with creation of
CSR Director role.
Pictured: first Director
David Comb

Rising Black Scientist Awards
There is a representation problem within the U.S. scientific community.
Acknowledging the problem is an important first step, but it was important
to us to take immediate action to diversify the voices at the table–and in thelab, especially after the murder of George Floyd in 2020.
The annual Rising Black Scientists Awards were established with
Cell Press to provide a $10K cash prize and $1K in scientific materials
to two promising African American scientists in the U.S. The winners’
personal essays are published in the journal Cell. One undergraduate andone graduate or post-doctoral scholar are chosen by an independent
panel of reviewers.

Elle Lett, PhD, 2021
graduate Rising
Black Scientists
Award winner• 2020 Undergraduate winner Fola Olusanya of Howard University• 2020 Graduate Winner Chrystal Starbird, PhD of Yale University• 2021 Undergraduate winner Charleese Williams of Georgia State

Science Education Corporate Partners• Change is Simple 2018-2021 | $125K Instilling lifelong social& environmental responsibility through experiential learning that inspires
action for healthy people, planet, and community• Seeding Labs 2018-2021 | $41K Balancing the inequities ofresources to further scientific discovery

From 2018-2021, weawarded 20 STEM
student scholarships.
For 2021, we doubled
the number ofscholarships available
from 4 to 8 students
annually.

2009• First Greenhouse Gas
inventory completed

2010• Composting andcompostable food service
ware introduced

2011• First Sustainability
Coordinator hired

11

Protecting the Environment
Environmental Grants

A portion of our annual giving is earmarked for environmental causes. These funds help support local
conservation and preservation projects, address the loss of biodiversity, and engage the public with nature.
Every year, our Environmental Grant Committee always has a stack of quality proposals to sort through.
Of course, it would be wonderful to fund everything. Here are a few of the organizations receiving grants.
• Ecologic Development Fund
• Seaside Sustainability• Girls Inc. of Lynn
• Supportive Living• Backyard Growers

Environmental Corporate Partners• Greenbelt 2018-2021 | $27K: Championing conservation of
farmland, wildlife habitats, and scenic landscapes throughout theEssex County region• Ipswich River Watershed Association

2018-2021 |$50K: The voice of the Ipswich River, protecting natureand ensuring that there is enough clean water for people, fish, andwildlife—for today and future generations

We awarded $293K
in 46 environmental
grants from 20182021. These helped
preserve habitats
and wildlife andprovide preservation
education.

Aerial view of Russell Orchards in
Ipswich, Massachusetts, protectedby our Corporate Partner, Greenbelt;
Greenbelt works within the 34 cities andtowns of Essex County, Massachusetts,
helping individuals, families,
municipalities, and organizations
realize their conservation goals.

Photo: Greenbelt

2011• Alternative Transportation
Program implemented

			
12

2012
• LEFE qualified bonuses begin

2013• Bio cooler introduced toreplace sEPS foam forshipping• Mesoamerican Reef Marine
Conservation catalog

Community Support: Helping the Underserved
Community Grants

A percentage of our annual giving is reserved for the communities in which
we operate. These funds help provide, food, shelter, safety, and services tolocal residents in need. The Community Grant Committee determines which
eligible groups will receive funds each year. Here are some of the highlightsfrom the last few years.
• The Open Door/Cape Ann Food Pantry• North Shore Alliance of Gay, Lesbian, Bisexual, and Transgender Youth• Healing Abuse Work for Change• Lifebridge• Pathways or Children, Inc.

Disaster Relief
CST matches funds for global disaster relief donations by employees.
The following is a sample of employee + corporate combined giving.
• 2018 | $8,365: California Wild Fire Disaster Relief

CST awarded $394K
in 79 community
grants from 20182021. The grants
helped provide
community food,shelter, andrecovery programs.

• 2019 | $7,895: Hurricane Dorian Relief• 2020 | $50,794: Wildfires in Australia, Earthquake in Puerto Rico,
COVID outbreak in Wuhan• 2020 | $7,797: India COVID Relief• 2020 | $25,000: Japan Disaster Relief• 2020 | $19,936: U.S. Racial Justice (not including Rising Black
Scientists Awards):• 2021 | $27,000: U.S. Wildfires, Flooding in Germany, Earthquake in
Haiti, Kentucky Tornado Relief

Community Corporate Partners• Beverly Bootstraps 2018-2021 | $75K: Providing critical

Employees work at a local food bank,Haven from Hunger, separating andpackaging food for clients.

resources to families and individuals to achieve self-sufficiency: food,housing, education, counseling, and advocacy• LEAP for Education 2018-2021 | $21K: Empowering 		first-generation-to-college and underserved youth to graduate fromcollege and succeed in career and life

2013
• Employee community
gardens established2013• Small Grants program
established

			

2013
• Tozer Road facility
renovation
complete withseveral energy- 		
efficient upgrades

13

Global Giving
We enjoy gathering for summer and winter company events, but safety
protocols dictated that we forego such events during the COVID-19
pandemic. $150K that would have been used for company social eventswere donated to organizations across the globe, chosen by employees.

Employee-nominated Global Giving Recipient
Organizations (2021):• Beverly Bootstraps (U.S.)• Sierra Club Foundation (U.S.)• Han Hong Love Charity Foundation (China)• One Foundation (China)• Katariba (Japan)• Kidsdoor (Japan)• The Ocean Cleanup (Global)• Red Cross EU (Europe)• World Food Programme (Global)• Environmental Defense Fund (Global)
Supporting the Arts
Science and art are both intimately connected and universal languages.
You need to think creatively to inspire new science and truly innovate. CST
values this relationship and helps to foster it through our Arts Support
Programs.
We invite professional global artists to show their work in rotating exhibitions
to spark creativity and connect with our internal community.
We also encourage our own talented employees to show their work
(paintings, collage, photography, music, and dance) to inspire each otherand create bonds to strengthen our work culture. CST has curated acollection of work created by local artists, which is displayed in ourfacilities for employees to enjoy.
Michael Aghahowa with some of his many self-portraits
he created while attending Raw Art Works (RAW) - RAW is
located in Lynn, MA and provides free art therapy-based
programming to hundreds of young people in the community
every year. It is a place where youth build trusting
relationships, learn to express themselves through art,and make plans for the future.
Photo: Raw Art Works

2014• Nitrile glove take-backprogram started

14

2014
• Volunteer program begins

2014• First EV bonus given to
employeeArts Corporate Partners• Monserrat College of Art 2018-2021 | $20K: Providing

a place of inspiration, respect, and encouragement, where young artists
can develop their talents and achieve their vision• Raw Art Works 2018-2021 | $28K: Providing children thetools to create in unexpected ways and envision new possibilities for 		
their future

Company Culture

Diversity, Equity, and Inclusion
We strongly believe that diverse, inclusive environments are critical for
maximizing scientific achievement. Throughout history, so much scientificpotential has been squandered because of prejudice and bias. This mustend. We strive to develop a culture that cherishes its employees and thediversity of their ideas.
A monthly seminar series of external, expert speakers was launched in 2021,
providing CST employees opportunities to learn more about supporting
inclusive culture. Topics from the first year included: Unconscious Bias,
Equity and Equality, Belonging, Women in Leadership, Microaggression,
Confronting Ableism, Minding Your LGBTQ+, Diversity and Innovation,
Beating the Odds as an Immigrant, Prioritizing Mental Health, andBecoming Good Allies.

Diversity is the mix...
Inclusion is making
the mix work.”- Andrés Tapia

CST has committed to 50% diversity representation on the corporate
Leadership Team by 2025.
• Employee Resource Groups have been founded to support LGBTQ and
Women in Science within the CST community.
• A Reverse Mentorship Program was initiated to give members of CST
leadership fresh perspective on company culture and how young workers
regard careers and development.
• A CST Employee Art Auction to benefit US Racial Justice was hosted in
2021. Matching funds were donated to support the cause.

Andrés Tapia is a Senior Client Partner
and is Korn Ferry’s Global Diversity
and Inclusion Strategist. He is theauthor of several books on diversity
and inclusion, most recently The 5
Disciplines of Inclusive Leaders:
Unleashing the Power of All of Us.

2014• High-efficiency
ULT freezer( Stirling) piloted

2014• EV charging stations
are installed at Trask
Lane facility

2015• Global offices areincluded in
CSR programs

15

Global Employee Engagement
Balance is so important, especially when it comes to engagement. Are wecreating opportunities to get involved in all the areas we value: work/lifebalance, creating positive change, helping others and the environment?
Employee engagement opportunities at CST include:• Art Exhibitions• CSR Speaker Series• Lunch and Learn Knowledge Sharing• Friday Company Talks• Hobby and Interest Series• Clubs and Teams
In 2021, CST offically completed our
first-ever international cycling fundraising ride Stofwisselkracht (Metabolic
Force) to raise money for metabolic
disease in children. Employees fromacross the globe rallied to support thisimportant cause.

• Multicultural Potluck• Employee Concerts• Community Volunteering

CST employees in Danvers,
Massachusetts enjoy home-cooked
meals from their coworkers’ homelands,
an annual tradition we call The
Multicultural Potluck.

2015
Cell Signaling Technology
Empowering our Employees, Strengthening our Communities, and Reducing our Environmental Footprint

Corporate Social Responsibility
2014 Annual Report

16• First CSR Report is published• Science Scholarshipestablished2015• Compostable cup reduction
challenge to promote reuse

2016• EV Bonus begins

17-20% of our employees at CST
serve on our committees and boards
for a 2-4 year term. This truly meansthat the voices driving our awards
are those of our employees.

Employees volunteering outside of a
local grocery store collecting donations
to support our valued nonprofit
Community Partner, Beverly Bootstraps

Employee-run Committees at CST:
• Grant Committees• Scholarship Committee• Internship Committee• 401K Committee• Volunteer Committee• Green Committee

Photo: Kim Lee

Employees hard at work assembling
furniture for local nonprofit A Bed forEvery Child2016• Commit to Paris Agreement by
reducing greenhouse gas
emissions annually

2017• Solar PV arrays installed atboth U.S.-based facilities

2018• LED upgrades and retrofits
at both U.S.-based facilities

17Planet & Health
There’s no question that the planet is in crisis; the effects
of climate change are evident. The planet’s biodiversity is in jeopardy andthe science to understand the cause is clear. The only question we face
every day is: what can we do about it? It’s easy to dismiss individual action
when, at times, that contribution seems too small to make a difference. We
believe that corporate action must be paired with sustainable actions we
can all take in our everyday lives. We must empower employees, customers,
and our communities with the tools to create positive change.
The life science industry does a lot of good. We provide tools that help
researchers make discoveries to treat and cure disease. However, we also
use a lot of energy and resources in the process. The first step is toacknowledge the environmental costs. Then you can innovate and lead.
How can we continue to make the best research tools we can, but cut ourgreenhouse gas emissions in the process? Can we operate safely while
trying to eliminate single-use items? Can we think creatively about transport options and how our indvidual footprints together form the whole?

Image shared by our CST China officecolleagues of the devastation causedby flooding in the summer of 2020the intensity and frequency of
weather events continue to increase
due to climate change.

As important as it is to grow our business, the goal has always been to
improve human health overall. We must make sure that our employees workin healthier spaces, have a good work-life balance, and live a complete life
beyond the value they bring to CST. We must take advantage of theopportunities we have to go beyond our area of expertise and contribute toendeavors to create a better, healthier world whenever we are able.

A Fiery-throated Hummingbird(Panterpe insignis) typically found in
mountain cloud forests above 4,000 feetin Costa Rica and Panama
Photo: Carrol Henderson

2018• Corporate partnerships created as
Nonprofit Alliance Members

18

2018
• Disaster Relief Matching Program
established: Up to $25K/year in matching 		
funds

2018
• Employee Donation Matching 		
program created: $300 annually per
employee/yearReducing Emissions
CST is reducing its greenhouse gas emissions through energy conservation
measures and equipment upgrades, purchasing energy-efficient,ultra-low-temperature freezers, upgrading fume hoods and biosafetycabinets, and installing onsite renewables.

Solar panels installed at Trask Lane and Tozer Road facilities (U.S.)• Solar at Tozer Road has generated
776 MWh over its lifetime and avoided
466 MTCDE• Solar at Trask Lane has generated
323 MWh over its lifetime and avoided
194 MTCDE

MWh = Megawatt Hours • MTCDE = Metric Tons of Carbon Dioxide Equivalent

Onsite renewables ensure the use ofclean energy and help reduce CST
greenhouse gas emissions to combat
climate change.

Alternative Transportation ProgramThis Program offers incentives to our U.S.-based employees who commuteto and from work via carpool, bicycle, public transit, jogging, walking, andeven riding a motorcycle. Employees can earn an extra 2 days off per year
or pay it forward by donating proceeds to an environmental nonprofit of
their choice.

2019• Automatic sash closers for fumehoods installed at both U.S. facilities• $25K/year of matching funds 		
reserved to complement employee
personal donations

There have been
90 participants in
the Alternative
Transportation
Program since
2018.

2019
• Wildflower habitation pollinator 		
project planting along highway at
Trask Lane facility

19

Electric Vehicles Infrastructure
CST has committed to the future of electric vehicles (EV). We offer a $2K
rebate paid to employees who purchase an EV for their personal vehicle.
There are a total of 22 charging stations installed at U.S. facilities that are
free to use and open to the public.

Sustainable Business Travel
As a global business, a certain amount of international travel is necessary.
Offsetting the carbon footprint of these activities is also becoming a priority
throughout the organization.
The CST Netherlands office reduces CO2 emissions by using green seats
for each flight and working closely with Climate Neutral Group to invest in
climate projects, like the Borehole Uganda Project. By offsetting and flying
100% climate neutral, we minimize our impact on the climate and give
people in a country like Uganda access to clean energy and a better
standard of living.

57 CST employees
have purchased
personal electricvehicles to date. This
represents about
14% of the company,
and over 4x the U.S.
average for new car
sales.

Jeske Koomen from our Netherlands officevisited the Borehole Uganda Project thatwas funded through our commitment to
reducing our CO2 emissions calculated
through business travel.

2019• Beehives at Trask Lanefacility through Beverly
Bees

20

The CST Netherlands
office tracks andoffsets all greenhousegas emissions
associated with air
travel.
2020

2019• Commit to no pesticides used
onsite for landscaping at both 		U.S.- based facilities		• First Annual
Rising Black
Scientist Awards
in U.S.

Photo: Jonathan King, Senior Research Associate in Antibody Manufacturing

Nature and Ecosystems
We only get one planet. Its survival and our own are inextricably linked. We
also seek to take physical corrective action where we can. These represent
some of our initiatives to promote planetary health.

Pollinator Protection
Pollinator gardens were created at the Trask Lane facility in 2019, and havealways existed at our Tozer Road facility. These gardens offer pollinators
access to wildflowers in more continuous open spaces. To protect ourpollinators, we have made a commitment to no pesticide use onsite forlandscaping.

Community Garden
A community garden is maintained by the CST Garden Club, which isalso teaching individuals how to grow their own produce, promoting
plant-based diets, healthy soil, and biodiversity. Harvested produce isavailable to employees and has been served in our cafeterias.

Responsible Printing
In the past, the biotech industry utilized printed catalogs to describe
product offerings. Initial CST catalogs offered some of our earliest
opportunities to raise awareness for environmental conservation throughtargeted themes like Plight of the Pollinators and Mesoamerican Reef
Marine Conservation. We have since moved to digital catalogs, but when
we need to print, we do so responsibly by printing on-demand, using
eco-friendly paper and soy-based inks whenever possible.

Employee Wellness
Our important work begins with the health and wellness of employees. It’s
important to nurture every part of ourselves and come to work every day
refreshed. CST globally offers employees:• Plant-based food options served in our cafeterias• Onsite and virtual yoga classes• Step Challenges to promote health and physical activity• Weight loss support through on-site Weight Watchers and health andwellness challenges• Running, outdoor, fitness, cycling, dance, tennis, and other clubs topromote exercise• Shower and changing rooms as well as bike storage at U.S. facilities for
cyclists and participants in the Alternative Transportation program

2020• Four additional annual
scholarships dedicated to 		supporting students of color

2020• DE&I Committee founded• DE&I Seminar Series
launches for employees
globally

The CST Garden Club grows flowers for
local pollinators and a wide variety of
produce.

2021• Director of Sustainability
position created and filled,
reporting to CEO

2022• CST joins 1% for
the Planet21

Promise for Tomorrow
In the early days of CST, one of our goals was to make the best research
antibodies we could. As researchers ourselves, we saw that was a big needin our scientific community. Twenty-two years later, we’re still making thebest reagents available. We’ve never wavered in that commitment since thebeginning because our foundation is a strong belief in the positive impact ofscience on society and uncompromising business ethics.		
Researchers have used our tools to uncover biological mechanisms ofaction, to unlock the interplay and connection that cell signaling plays
throughout biology, and to study disease and seek therapeutic solutions. We
couldn’t be prouder of the discoveries we’ve made, the discoveries we’ve
made possible with our products, and the contributions made by sharing
knowledge and collaborating with fellow scientists. We are deeply
convinced that through our work and the quality we provide to so many
biomedical researchers we contribute to making the world a better place.
				
Now that we have achieved some of our scientific and business goals, werealize there are more opportunities to expand our impact. We can also
directly influence the lives of those in our community through outreach andphilanthropy. We can encourage everyone inside and outside the company
to live a life that balances health and work with art and seeks to enrich andprotect our natural and human environments.
			I’m honored to be part of an organization that believes in building abetter world. Our promise is to never stop searching for ways to improve,
fostering sound science, finding sustainable solutions, promoting wellness,and creating spaces for us all to be more connected.

Roby Polakiewicz,
Chief Scientific Officer
Cell Signaling Technology

22

Looking Forward
The Life Sciences have a major impact on the planet. Across the industry, research is resourceintensive and consumes massive amounts of energy which generates greenhouse gas
emissions. It relies heavily on single-use plastic that continues to fill our landfills and ouroceans. Life science research also generates hazardous waste that must be disposed ofproperly so that it does not enter the environment.
CST must be a leader in this space and demonstrate to our peers, Customers, and competitorsthat we can play a key role in advancing sustainability to combat climate change and improveplanetary health.
As such, our sustainability goals focus on emissions, waste, water, giving, and individual action.
Corporate goals are essential, but as individuals, we all have the ability to participate throughsustainable actions in our everyday lives. What may seem like small steps will add up.
CST has an ambitious, science-based climate goal to achieve net-zero emissions by the 30th
anniversary of our founding, in 2029. Scientists agree the world needs to attain net-zeroemissions by 2050 to limit global warming to no more than 1.5 degrees Celsius above preindustrial levels, simply to avert some of the worst impacts of climate change. We believe that
we need to act now and demonstrate to other organizations and individuals what is possible.
We will continue to strengthen and globalize our corporate social responsibility efforts andgiving through an inspiring philanthropy goal. We will pursue this goal starting in 2022 bybecoming a member of 1% for the Planet and joining the global network of businesses,
individuals, and nonprofit organizations tackling our planet’s most pressing environmental
issues.
The 1% for the Planet movement allows us all to participate in a myriad of ways. Through dailypurchases, partnerships, and memberships, we bring diverse efforts together to create agroundswell of collective action. It’s an incredible opportunity, and we are creating powerfuland effective change together. Becoming a 1% for the Planet Business Member is an investment
in ethical, relevant business for the future of our planet and people.
We are excited to drive progress and engage with you to create impactful actions andsolutions. Our efforts are stronger together.

Krystyna Hincman,
Director of Corporate Social Responsibility
Cell Signaling Technology

Anthony Michetti,
Director of Sustainability
Cell Signaling Technology

23

Cell Signaling Technology (CST) is a different kind of life
sciences company—one founded, owned, and run by
active research scientists, with the highest standards ofproduct and service quality, technological innovation,and scientific rigor for over 20 years. We consistently
provide fellow scientists around the globe with bestin-class products and services to fuel their quests fordiscovery. CST is a company of caring people driven
by a devotion to facilitating good science—a company
committed to doing the right thing for our customers,
our communities, and our planet.

© 2022 Cell Signaling Technology, Inc. Cell Signaling Technology, CST, and XP are trademarks of
Cell Signaling Technology, Inc. All other trademarks are the property of their respective owners.
Visit cellsignal.com/trademarks for more information.

www.cellsignal.com

CST Antibody Performance Guarantee:
CST antibodies are guaranteed to work – first time, every time
To learn more, please visit: www.cellsignal.com/abguarantee.

21-BCH-30598-MAR22 For Research Use Only. Not For Use in Diagnostic Procedures.