January, 2018

CURRICULUM VITAE

Hitoshi YOKOYAMA, MD, PhD
Professor and Chairman
Dept. of Cardiovascular Surgery
Fukushima Medical University
Fukushima 960-1295
JapanE-mail: hitoshiy@fmu.ac.jp
PROFESSIONAL APPOINTMENT:
2012.4-2014.3
Executive Director, Fukushima Medical University
2006.4-2012.3
Deputy Director, Fukushima Medical University Hospital
2001.1- Present Professor and Chairman
Dept. of Cardiovascular Surgery
Fukushima Medical University
1996.8-2000.12 Associate Professor
Dept. of Thoracic & Cardiovascular Surgery
Tohoku University School of Medicine, Sendai, Japan
1094.8-96.7
Research Associate (supported by Uehara Memorial Research Foundation,
Japan), Dept. of Cardiothoracic Surgery, Medical Collage of Pennsylvania &Hahnemann University, Philadelphia, USA
1994.7-96.7
Assistant Professor
Dept. of Thoracic & Cardiovascular Surgery, Tohoku University School of
Medicine, Sendai, Japan
1992.6-94.6
Stuff Surgeon
Dept. of Cardiovascular Surgery, Aomori General Hospital, Aomori, Japan
1991.4-92.5
Clinical Fellow
Dept. of Thoracic & Cardiovascular Surgery, Tohoku University Hospital,
Sendai, Japan
1983.4-87.3
Resident
Division of Cardiothoracic Surgery & Anesthesiology, Department of Surgery,
Mito National Hospital, Mito, Japan
CERTIFICATION:
1992.4
1989.4
1987.2
MEMBERSHIP:

JOURNAL:

Japanese Board of Cardiothoracic Surgery
Japanese Board of Surgery
Japanese Board of Anesthesiology
Japanese Society for Cardiovascular Surgery (Board member 2008-, Secretary
General 2013-, President 2018-)
Japanese Association for Thoracic Surgery
Japanese Circulation Society（Board member 2014-）
Japan Surgical Society
American Heart Association (Fellow)
International Society for Minimally Invasive Cardiothoracic Surgery
European Association for Cardiothoracic Surgery
Society of Thoracic Surgery
American Association of Thoracic Surgery
Journal of Japanese Society for Cardiovascular Surgery：Editor in Chief
Circulation Journal: Associate editor
Gen Thorac Cardiovasc Surg: Associate editor-in-chief（2013-14）

1January, 2018

EDUCATION:
1987.4-91.3
1977.4-83.3

Tohoku University Graduate School of Medicine
Tohoku University School of Medicine

CLINICAL INTEREST:
Off-pump coronary artery bypass
Mitral valve surgery
Aortic surgery
RESEARCH INTEREST:
Cardiovascular Pharmacology
Heart Transplantation
Cardiac ischemia-reperfusion injury
Stem-cell transplantaion for ischemic heart disease
Three-dimensional analysis of coronary artery motion
SELECTED PUBLICATONS:
1.

Irie Y, Kondo S, Rokkaku K, Tsuboi E, Takano H, Yokoyama H. Obturator foramen bypass for infective groincaused by closure device. Asian Cardiovasc Thorac Ann. 2016, [Epub ahead of print]

2.

Ishida K, Satokawa H, Takase S, Kagoshima A, Takano T, and Yokoyama H. Video-assisted endoscopic
resection of left ventricular papillary fibroelastoma through the aortic valve. Asian J Endosc Surg. 2016, [Epubahead of print]

3.

Katada Y, Kondo S, Tsuboi E, Rokkaku K, Irie Y, Yokoyama H. Endovascular total arch repair using in situ
fenestration for arch aneurysm and chronic Type A dissection. Ann Thorac Surg. 101(2), 625-630, 2016.

4.

Sato Y, Satokawa H, Yamamoto A, Yokoyama H, Maehara K. Giant right atrial diverticulum with thrombos
formation. Asian Cardiovasc Thorac Ann. 23 (3), 314-316, 2015.

5.

Kurosawa H, Seto Y, Wakamatsu H, Sato Y, Takase S, Omata S, Yokoyama H. Effects of phenylephrine andnoradrenaline on coronary artery motion in an open-chest porcine beating heart model.

Surgery Today. 44 (6),1128-1137, 2014.

6.

Satokawa H, Takase S, Seto Y, Yokoyama H, Gotoh M, Kogure M, Midorikawa H, Saito T, Maehara K.
Management strategy of isolated spontaneous dissection of the superior mesenteric artery. Ann Vasc Dis. 7(3),
2014.

7.

Igarashi T, Takahashi S, Takase S, Yokoyama H. Intraoperative thrombectomy for occluded carotid arteries inpatients with acute aortic dissection: report of two cases. Surg Today. 44(6), 1177-9, 2014.

2

January, 20188.

Igarashi T, Takase S, Satokawa H, Wakamatsu H, Kurosawa H, Yokoyama H. Left ventricular noncompaction
complicated by mitral valve prolapse: Report of a case.

9.

Surg Today. 43, 818-820, 2013.

Igarashi T, Takase S, Satokawa H, Misawa Y, Wakamatsu H, Sato Y, Kukosawa H, Seto Y, Tsuboi E,
Yokoyama H. Open-stent grafting with a GORE TAG Thoracic Endoprosthesis for an extended severely
atheromatous thoracic aortic aneurysm: Report of a case. Surgery Today. 43(1), 103-105, 2013.

10.

Igarashi T, Takase S, Satokawa H, Misawa Y, Wakamatsu H, Yokoyama H. Thoracic endovascular aortic repair
with viseral arteries intermittent clamp technique fro descending thoracic aortic aneurysm with shaggy aorta.
Ann Vasc Surg. 27(7), 974.e11-974.e14, 2013.

11.

Satokawa H, Seto Y, Yamamoto A, Yokoyama H, Kogure M, Ohtani S, Gotoh M. A case report ofaneuysmectomy after thrombo-intimectomy for spontaneous isolated superior mesenteric artery dissection. Ann
Vasc Dis. 15(2), 204-207, 2012.

12.

Seto Y, Yokoyama H, Takase S, Tanji M, Takahashi K, Takahashi S, Kondo S, Hagiwara K, Watanabe M.
The results of the enclose II proximal anastomotic device in 178 off-pump coronary artery bypass surgeries.
Innovations 7(4), 242-246, 2012.

13.

Wakamatsu H, Watanabe T, Sato Y, Takase S, Omata S, Yokoyama H. Landiolol reduces coronary artery
motion in an open chest porcine model: Implication for off-pump coronary artery bypass surgery. Surg Today
42:205-208, 2012.

14.

Wakamatsu H, Watanabe T, Sato Y, Takase S, Omata S, Yokoyama H. Selective beta-1 receptor blockade
further reduces the mechanically stabilized target coronary artery motion during beating heart surgery.
Innovations. 5, 349-354, 2010.

15.

Satokawa H, Yokoyama H, Wakamatsu H,and Igarashi T.

Comparison of endovenous laser treatment forvaricose veins with high ligation using pulse mode and without high ligation using continuous mode and lower
energy. Ann Vasc Dis. 3(1), 46-51, 2010.

16.

Takase S, Wakamatsu H, Yokoyama H. Short- and long-term outcome of the octogenarians after off-pumpcoronary artery bypass surgery. Gen Thorac Cardiovasc Surg. 58:561-567, 2010.

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January, 201817.

Wakamatsu H, Sato Y, Takase S, Sato Y, Satokawa H, Yokoyama H. Aortic arch repair with coronary arteryrevascularization. Fukushima J Med Aci. 55, 52-60, 2009.

18.

Saito T, Tsuchiya T, Kenjo A, Kimura T, Sato Y, Saito T, Anazawa T, Takase S, Satokawa H, Satoh Y,
Yokoyama H, Ohira H, Rai T, Gotoh M. Successful treatment ofpseudoaneurysms of celiac and superior
mesenteric arteries by combined endovascular and surgical approach.

J Hepatobil Panc Surg. 15 (4),444-448,2008.

19.

Sato Y, Satokawa H, Takase S, Misawa Y, Yokoyama H. Prolapse of aortic intimal flap into the left ventricle – A
rare cause of global myocardial ischemia in acute type A aortic dissection. Circ J. 70(2), 214-215, 2006.

20.

Watanabe T, Omata S, Odamura M, Okada M, Nakamura Y, Yokoyama H. Three-dimensional quantification ofcardiac surface motion: A newly developed three-dimensional digital motion-capture and reconstruction systemfor beating heart surgery. J Thorac Cardiovasc Surg. 132, 1162-71, 2006.

21.

Midorikawa H, Ogawa T, Satou K, Hoshino S, Takase S, Yokoyama H. Long-term results of endoluminal
grafting for descending thoracic aortic aneurysm. Jpn J Thorac Cardiovasc Surg. 53, 295-301, 2005.

22.

Izuha H, Hattori M, Igari T, Wakamatsu H, Watanabe T, Yokoyama H. Changes in platlet aggregation during
cardiopulmonary bypass: comparison of poly-2-methoxyethylacrylate and heparin as a circuit coating material.
Artif Organs. 8, 41-46, 2005.

23.

Yaoita H, Takase S, Maruyama Y, Sato Y, Satokawa H, Hoshi N, Ono N, Igari T, Ohto H, Yokoyama H.
Scintigraphic assessment of the effects of bone marrow-derived mononuclear cell transplantation combinedwith off-pump coronary artery bypass surgery in patients with ischemic heart disease. J Nucl Med. 46(10),1610-7, 2005.

24.

Yokoyama H, Sato Y, Takase S, Takahashi K, Wakamatsu H, Sato Y. Introduction of off-pump coronary artery
bypass into aortic arch repair: A new solution for the surgical treatment of multiorgan arteriosclerosis. J Thorac
Cardiovasc Surg. 129, 935-6, 2005.

25.

Sato Y, Yokoyama H, Watanabe M, and Hamada O. A surgical case of aortic valve replacement in patient withchronic idiopathic thrombocytopenic purpura. Fukushima J Med Sci. 50(1), 29-35, 2004.

4

January, 201826.

Ando M, Igari T, Ando S, Satokawa H, Yokoyama H. Repair of the aortico-left ventricular tunnel original fromthe right aortic sinus with severe aortic valve regurgitation. Annals of thoracic and cardiovasucukar surgery.
10(1), 47- 50, 2004.

27.

Yokoyama H, Takase S, Misawa Y, Takahashi K, Sato Y, Satokawa H. A simple technique of introducing
intracoronary shunts for off-pump coronary artery bypass surgery. Ann Thorac Surg. 78, 352-355, 2004.

28.

Satokawa H, Takahasi K, Hoshino Y, Yokoyama H, Saito T, Kazuma H.

Tuberculous pseudoaneurysm of theceliac artery. A case report. Int Angiol. 23(1), 85-8, 2004.

29.

Sato Y, Yokoyama H, Watanabe M, Hamada O. A surginal of combined vavular disease complicated by absent
right superior vena and persistent left superior

30.

Ando M, Igari T, Yokoyama H.

vena cava.

Ann Thorac Cardiovasc Surg. 9(6), 2003.

CT features of chronic contained rupture of an abdominal aortic aneurysm. Ann

Thorac Cardiovasc Surg. 9(4), 274-278, 2003.

31.

Sato Y, Yokoyama H, Satokawa H, Takase S, Maruyama Y. A report of a surgical case of papillary
fibroelastoma in the left ventricular outflow tract. Ann Thorac and Cardiovasc Surg. 9(4), 270-273, 2003.

32.

Yokoyama H. Aortic arch aneurysm complicated with coronary artery disease: Still a surgical challenge? Ann
Thorac Cardiovasc Surg. 8(2), 62-8, 2002.

33.

Igari T, Yokoyama H, Iwaya F, Hikichi H, Inagaki Y. Cardiopulmonary bypasss system-mountable anesthetic
machine: Pump operated with compressor. Artificial Organs. 25(10), 796, 2001.

34.

Sakuma K, Akimoto H, Yokoyama H, Iguchi A, Tabayashi K.Cryopreserved aortic homograft replacement in 3
patients with noninfectious Inflammatory vascular disease. Jpn J Thorac Cardiovasc Surg. 49(11), 652-655,
2001.

35.

Tabayashi K, Yokoyama H, Iguchi A, Watanabe S, Fukujyu T, Tsuru Y, Niibori K, Akimoto H, Tofukuji M.
Concomitant replacement of the aortic root and aortic arch with or without secondary thoracoabdominal aorta
replacement. Jpn J Thorac Cardiovasc Surg. 49, 42-46, 2001.

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January, 201836.

Iguchi A, Tsuru Y, Yokoyama H, Tabayashi K. Open surgical repair for a perigraft leak after endovascular
stent-graft emplacement of descending thoracic aorta. Jpn J Thorac Cardiovasc Surg. 49,618-620, 2001.

37.

Akimoto H, Tsuru Y, Yokoyama H, Sadahiro M, Tabayashi K. Commissure holder: An innovative device foraortic valve-sparing technique Ann Thorac Surg. 71, 1380-1381, 2001.

38.

Fukuchi M, Watanabe J, Kumagai K, Katori Y, Baba S, Fukuda K, Yagi T, Iguchi A, Yokoyama H, Miura M,
Kagaya Y, Sato S, Tabayashi K, Shirato K. Increased von Willbrand factor in the endocardium as a local
predisposing factor for thrombogenesis in overload human atrial appendage. J Am Coll Cardiol. 37, 1436-42,
2001.

39.

Yokoyama H, Ohmi M, Sadahiro M, Shoji Y, Moizumi Y, Tabayashi K. Spontaneous rupture of the thoracic
aorta. Ann Thorac Surg. 70, 683-689, 2000.

40.

Sato K, Iguchi A, Tanaka Y, Hata M, Sadahiro M, Yokoyama H, Ohmi M, Tabayashi K. Pedicled pericardial flap
for pulmonary artery in adult dogs. Jpn J Thorac Cardiovasc Surg. 48, 211-216, 2000.

41.

Sakurai M, Fukuyama N, Iguchi A, Akimoto H, Ohmi M, Yokoyama H, Nakazawa H, Tabayashi K. Quantitative
analysis of cardiac 3-L-nitrotyrosine during acute allograft rejection in an experimental heart transplantation.
Transplantation. 68, 1818-1822, 1999.

42.

Mohhiudin M, Yokoyama H, Reiss R, DiSesa VJ. Induction of tolerance to “untoleralized strain” by double strain
thymic innoculation in experimental rat cardiac transplantation. Transplant Proc. 31, 1-2, 1999.

43.

Niibori K, Wroblewski KP, Yokoyama H, Crestanello JA, Whitman GJR. Bioenergetic effect of liposomal
coenzyme Q10 on myocardial ischemia reperfusion injury. BioFactors. 9, 307-313, 1999.

44.

Yokoyama H, Sadahiro M, Iguchi A, Ohmi M, Tanaka S, Tabayashi K. Remnant omental transfer for the
mediastinitis after coronary revascularization with right gastro-epiploic artery. Ann Thorac Surg. 68, 269-271,
1999.

45.

Ohmi M, Tabayashi K, Hata M, Yokoyama H, Sadahiro M, Saito H. Brain damage after aortic arch repair using
selective cerebral perfusion Ann Thorac Surg. 66, 1250-1253, 1998.

6

January, 201846.

Niibori K, Wroblewski KP, Yokoyama H, Crestanello JA, Whitman GJR.Bioenergetic effect of acuteadministration of liposomal coenzyme Q10 on myocardial ischemia reperfusion injury. Surgical Forum. 49,
237-238, 1998.

47.

Niibori K, Yokoyama H, Crestanello JA, Whitman GJ. Acute administration of liposomal Coenzyme Q10
increases myocardial tissue levels and improves tolerance to ischemia reperfusion injury. J Surg Res, 79,
141-145, 1998.

48.

Whitman GJR, Niibori K, Yokoyama H, Crestanello JA, Lingle DM, Momeni R.

The mechanism of coenzyme

Q10 as therapy for myocardial ischemia reperfusion injury. Molec Aspects Med. 18, 195-203, 1997.

49.

Shen Z, Mohiuddin M, Yokoyama H, Reiss R, DiSesa VJ. Induction of tolerance to an experimental cardiac
allograft through intrathymic inoculation of class II major histocompatibility disparate antigens. J Thorac
Cardiovasc Surg. 112, 1315-1318, 1996.

50.

Shen Z, Pelletier S, Mohiuddin M, Yokoyama H, Reiss RG, DiSesa VJ. Different immune effects on cardiac
allografts and xenografts induced by neonatal intrathymic inoculation with allogeneic and xenogeneic antigens
J Heart Lung Transplant. 15, 1034-1038, 1996.

51.

Yokoyama H, Momeni R, Goldstein C, Mohiuddinn M, Shen Z, Fyfe B, Whitmann G, DiSesa VJ. Effect ofvesnarinone, a novel orally active inotropic agent with an immunosuppresive action, on experimental cardiac
transplantaion in rats. Transplantation. 62, 1540-1543, 1996.

52.

Yokoyama H, Lingle DM, Crestanello JA, Kamelgard J, Kott BR, Momeni R, Millili J, Mortensen SA, Whitman
GJ. CoQ10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect.
Surgery. 120, 189-196, 1996.

53.

Shen Z, Mohiuddin M, Goldstein C, Yokoyama H, DiSesa VJ. Durability of donor-specific and organ-specificheart transplant tolerance induced by intrathymic pretreatment with allogeneic spleen cells. J Thorac
Cardiovasc Surg. 111(2), 429-423, 1996.

54.

Mohiuddin M, Shen Z, Yokoyama H, Goldstein C, DiSesa VJ. Improved experimental cardiac xenograft survivalwith cyclophosphamide and intrathymic donor cells. Xenotransplantation. 3, 260-263, 1996.

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January, 2018

55.

Mohiuddin M, Shen Z, Goldstein C, Yokoyama H, DiSesa VJ. The molecular immunology of transplantation:
Monoclonal antibody to a specific T-cell receptor chain prolongs experimental heart graft survival. Surgical
Forum. 47, 35-37, 1996.

56.

Goldstein C, Reiss R, Yokoyama H, Shen Z, Mohiuddin M, Momeni R, Pelletier S, DiSesa VJ. A clinicallyapplicable intrathymic pretreatment regimen produces tolerance to experimental cardiac transplants. Surgical
Forum. 47, 245-247, 1996.

57.

Yokoyama H, Momeni R, Kott B, Crestanello JA, Whitman GJ. Improved coronary vasodilatory function after
ischemia reperfusion by lyposomal coenzyme Q10; Comparison with other antioxidant agents Surgical
Forum.47, 237-238, 1996.

58.

Mohiuddin M, Shen Z, Goldstein C, Yokoyama H, DiSesa VJ. Experimental cardiac xenografting with irradiationand intrathymic and intravenous xenogeneic cells.

59.

Transplant Proc. 28, 673, 1996.

Shen Z, Mohiuddin M, Goldstein C, Yokoyama H, DiSesa VJ.

Tolerance to experimental cardiac allografts but

not xenografts is induced after simultaneous neonatal intrathymic inoculation with allo-and xenogeneic cells.
Transplant Proc. 28, 719-720, 1996.

60.

Goldstein C, Reiss R, Mohiuddin M, Shen Z, Yokoyama H, DiSesa VJ.
a time lag between intrathymic treatment and transplantation.

61.

62.

Tolerance to cardiac allografts requires

J Surg Res. 63, 3-5, 1996.

Yokoyama H, Goldstein CD, Shen Z, Mohiuddin M, DiSesa VJ.

The effects of double strain intrathymic

inoculation on tolerance induction to experimental cardiac allografts.

Surg Forum.

46, 244-246, 1995.

Yokoyama H, Ohmi M, Murata S, Nakame T, Tabayashi K, Mohri H. Proposal of working left heart model with aheterotopic transplantation technique in rats. J Heart Lung Transplant. 14, 706-712, 1995.

63.

Yokoyama H, Haneda K, Satoh N, Ohmi M, Miura M, Satoh K, Mohri H. Early and late results after correction ofventricular septal defect with Down syndrome. Asian Cardiovasc Thorac Ann. 3, 23-25, 1995.

64.

Yokoyama H, Tanaka S. Simple arterial graft holder for coronary artery bypass grafting. Ann Thorac Surg. 59,
33-34, 1995.

8

January, 201865.

Tabayashi K, Ohmi M, Togo T, Miura M, Yokoyama H, Akimoto H, Murata S, Ohsaka K, Mohri H. Aortic arch
aneurysm repair using selective cerebral perfusion. Ann Thorac Surg. 57, 1305-1310, 1994.

66.

Yokoyama H, Maida K, Takahashi S, Tanaka S. Purulently infected abdominal aortic aneurysm: In situ
reconstruction with trans-mesocolic omental transposition technique. J Cardiovasc Surg. 2, 78-80, 1994.

67.

Yokoyama H, Togo T, Murata M, Osaka K, Tabayashi K, Mohri H. Cardiac over-dilatation after cardiopulmonary
bypass: Ceramic plate technique for sternal splinting. Ann Thorac Surg. 56, 971-972, 1993.

68.

Yokoyama H, Ohmi M, Iguchi A, Nakame T, Murata S, Tabayashi K, Mohri H. Changes in myocardialbeta-adrenergic receptors during acute rejection of heterotopically transplanted rat hearts. J Thorac Cardiovasc
Surg. 104, 1567-1571, 1992.

69.

Ohmi M, Yokoyama H, Nakame T, Murata S, Akimoto H, Tabayashi K, Mohri H. Hemodynamic performance ina heterotopically transplanted dog heart:oposal of techniques for working left heart model of heretotopic(abdominal) heart transplantation. J Heart Lung Transplant. 11, 1147-1150, 1992.

70.

Yokoyama H, Ishii K, Yanagisawa T, Taira N. An explanation of bell shaped dose-positive inotropic effect for
denopamine in canine right ventricular muscle. J Cardiovasc Pharmacol. 14, 570-576, 1989.

71.

Gotanda K, Yokoyama H, Satoh K, Taira N.

Cardiohemodynamic effects of cromakalim and pinacidil,

potassium channel openers, in the dog: Special reference to venous return.

J Cardiovasc Drug Therap. 3,507-515, 1989.

72.

Yokoyama H, Imagawa J, Satoh K, Taira N, Tamahashi N. Isolated dog hearts prepared in cold Tyrode solution
and reperfused with arterial blood are functionally and ultrastructually normal.

Tohoku J Exp Med. 156,

121-134, 1988.

73.

Yokoyama H, Yanagisawa T, Taira N. Details of mode and mechanism of action of Denopamine, a new orally
active cardiotonic agent with affinity for beta 1-receptors. J Cardiovasc Pharmacol. 12 (3), 323-331. 1988.

BOOK CHAPTERS
1.

Yokoyama H. Indication and safe strategy：Off-Pump Coronary Artery Bypass. Springer Japan, Tokyo, 39-44,
2016.

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January, 20182.

Yokoyama H. Stabilization：Off-pump Coronary Artery Bypass, Springer Japan, Tokyo, 75-86, 2016.

3.

Yanagisawa T, Ishii K, Yokoyama H, Kurosawa H, Taira N. Selective stimulation of high-affinity beta1-receptors:
Its implication in the treatment of mild heart failure. Recent Progress in Failing Heart Syndrome.
Springer-Verlag, Tokyo, 281-302,1991,

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