ProceedingsInternational Symposium on Medicinal and Useful Plants
in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy

薬学・生命科学分野における薬用・有用植物に関する４国間国際シンポジウム

June 1-2, 2024

主催：熊本大学薬学部
共催：４国間（日本・ネパール・トルコ・イタリア）国際シンポジウム組織委員会

組織委員長（共同）：渡邊高志、藤田美歌子
事務局：漢方・生薬「温故知新」講座組織委員会
会場: 熊本大学薬学部宮本記念館 （熊本市中央区大江本町 5-1）

Organizer: School of Pharmacy, Kumamoto University

International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, JapanInternational Symposium on Medicinal and Useful Plants in Pharmaceuticaland Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024

Welcome Message
1 June 2024
Dear Delegates:
On behalf of the Organizing Committee, I welcome you all to International Symposium on
Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences between Japan - Nepal –Turkey – Italy
The foundation of the Symposium is JSPS Bilateral Joint Research Project (2016-2017)“Development of inducers of anti-viral host factors based on Turkish medicinal plants and syntheticcompounds”. The Project is borderless, involving virologists, molecular biologists, medicinal
botanists, natural product chemists, synthetic organic chemists, and bioorganic medicinal chemists
between Japan to Nepal – Turkey - Italy sides.
The horizon of the Symposium is endless and limitless. We welcome all discipline of pharmaceuticaland biomedical sciences. We welcome very active discussion from participants of many countries.
Let’s kick off the global joint research with this Symposium.
Takashi Watanabe
Department of Medicinal Plants, School of Pharmacy
Kumamoto University, Japan.
Mikako Fujita
Department of Bioorganic Medicinal Chemistry, School of Pharmacy,Kumamoto University, Japan.
Stefano Dall'Acqua
Department of Pharmaceutical and Pharmacological Sciences,
University of Padova, Italy.
2International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, Japan

International Symposium on Medicinal and Useful Plants in Pharmaceuticaland Biomedical Sciences
between Japan and Nepal – Turkey - Italy

Date: June 1 (Sat.) - 2 (Sun.), 2024
Venue: Miyamoto Memorial Hall 1F, School of Pharmacy, Kumamoto University,
5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
Organizer: School of Pharmacy, Kumamoto University
Organizing Chair: Prof. Takashi Watanabe, PhD.
Department of Medicinal Plant, School of Pharmacy,Kumamoto University, Japan.
E-mail: wtakashi@kumamoto-u.ac.jp
Prof. Mikako Fujita, PhD.
Department of Bioorganic Medicinal Chemistry, School of Pharmacy
Kumamoto University, Japan.
E-mail: mfujita@kumamoto-u.ac.jp
Co-Organizer:

Stefano Dall’acqua, PhD.
Department of Pharmaceutical and Pharmacological Sciences,
University of Padova, Italy.
E-mail: stefano.dallacqua@unipd.it

Secretariat: Shyam Sharan Shrestha, PhD.
Himalayan Research and Development Center Nepal, Kathmandu, Nepal
E-mail: shyamsharan999@gmail.com
Supported by Kumamoto Organizing committee of the course on KAMPO Medicineand Herbal Medicine ‘Learning from the past’.

Co-Organized by the Organizing Committee of the Quadripartite(Japan, Nepal, Turkey and Italy) International Symposium.

3International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, Japan

Program ScheduleDay 1: June 1 (Sat.)

12:00

Reception

12:30

Opening remarks
Prof. Takashi Watanabe
School of Pharmacy, Kumamoto University, Japan

12: 45-13:00 Overview Remarks
Dr. Stefano Dall’acqua, University of Padova, Italy
Symposium Session I.
Pharmaceutical Sciences Zone
S-1

13:10 – 13:40

S-2

13:40 – 14:10

S-3

14:10 – 14:40

S-4

14:40 – 15:10

S-5

15:10 – 15:30
15:30 – 16:00

S-6

16:00 – 16:30

Residues of By-products as Natural Phenolic Sources
Prof. Dr. Nazim Sekeroglu
University of Gaziantep, Turkey
Zoom Online Invited Lecture -1
Reconstruction of Natural Product Scaffolding
Emeritus Prof. Dr. Masami Otsuka
Department of Medicinal and Biological ChemistryKumamoto University, Japan
Plant Resources and Human Life for a Sustainable Planet: Geospatial
Insights into Conservation and Management
Prof. Dr. Takashi Watanabe
Department of Medicinal Plant
Kumamoto University, Japan
Design, Synthesis and Structural Studies on New Anti-HIV Compounds
Based on a Plant Product Phytic Acid
Dr. Belgin Sever, Dr. Halilibrahim Ciftci
Department of Medicinal and Biological Chemistry
Kumamoto University, Japan
Coffee Break* 20 minEfficient Strategies for Unraveling Precise Taxonomic Relationships
among Medicinal and Useful Plants
Ms. Eranga Pawani Witharana
Analytical Research Center for Experimental Sciences
Saga University, JapanMedicinal and food plants: discovery and development of new
ingredients for the food supplements and functional foods
Prof. Dr. Stefano Dall’acqua
University of Padova, Italy
Zoom Online Invited Lecture -24

International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, Japan

S-7

16:30 – 17:00

S-8

17:00 – 17:30

Antiproliferative Activity of Saponin Compounds Isolated from Asteryomena against Human Gastric Cancer Cell Lines
Mr. Dongxing Wang
Department of Medicinal Plant
Kumamoto University, JapanPhytochemical Compounds of Himalayan Ethnomedicinal Plants ofNepal for Cancer Treatment
Dr. Shyam Sharan Shrestha
Himalayan Research and Development Center Nepal, Kathmandu, Nepal

Day 2: June 2 (Sun.)
Symposium Session II.
Botanist Zone & Biomedical
S-9

10:00 – 10:30

S-10

10:30 – 11:00

S-11

11:00 – 11:30

S-12

11:30 – 12:00

12:00 – 13:00

Hepatoprotective effects of Osbeckia octandra
Dr. Sudarma Bogahawaththa
Department of Advanced Lifesciences and Food Chemistry
Saga University, Japan
Genome analysis reveals insights into the genetic diversity of edible andmedicinal plants
Associate Prof. Dr. Yukio Nagano
Analytical Research Center for Experimental Sciences
Saga University, Japan
Development and application of thin film device for agriculture
Prof. Dr. Tokiyoshi Matsuda
Faculty of Science and Engineering
Kindai University, Japan
When Medicinal Plants meet Humanity: Traditional Spagyric medicine
in Italy
Ms. Mio Takahashi
Department of Environmental Humanities
Ca' Foscari University of Venice, Italy
Zoom Online Invited Lecture-3
Lunch Break5

International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, Japan

Poster Presentation Session (13:00 – 14:00)
Coordinator; Dr. Koji Sugimura

Department of Medicinal Plant, School of Pharmacy, Kumamoto University, Japan.
E-mail: sugimura@kumamoto-u.ac.jp
P-1

Comparison of the Bioactivity Evaluation and Active Constituents of Fudanso, aTraditional Vegetable of the Daylily Family, and Related Plants
Mr. Taisei Hayashi
Kumamoto University, Japan

P-2

Studying on the constituents of aerial parts of Genus Vitis (Fam. Vitaceae) and theevaluation of their physiological activities
Mr. Yuta Hosogoe
Kumamoto University, Japan
Comparison of Evaluation of Bioactivity and Active Components in Different Growth
Environments of Heracleum sphondylium L. var. nipponicum (Kitag.) H.Ohba
Mr. Taishi Ikagawa
Kumamoto University, Japan
Compositional Analysis of Higo Peony (Paeonia lactiflora) andComparison with Marketed Products
Mr. Genki Hidaka
Kumamoto University, Japan
Functionality evaluation about leaf of Higo peonies (Paeonia lactiflora)
Mr. Masatomo Yamauchi
Kumamoto University, Japan
Therapeutic Significance of the Medicinal Plant Ecballium elaterium, a Review
Mr. Berkay Beyri
Altinbas University, Turkey
Pyrimidine-Based New Thiazoles as Potential Anti-Lung Cancer AgentsDr. Halilibrahim Ciftci
Kumamoto University, Japan
Corn-Starch Based Gel Polymer Electrolyte for Improving of Electrochemical Double
Layer Supercapacitor
Dr. Sirin Siyahjani Gultekin
Ege University, Turkey
Development of a Man-made Phosphoinositide with Prodrug Groups
Mr. Takuya Masunaga
Kumamoto University, Japan
Design, Synthesis and In Vitro Determination of Anticancer Effects of New Naphthalene
Bearing Pyrazoline Compounds
Dr. Belgin Sever
Kumamoto University, Japan

P-3

P-4

P-5

P-6

P-7

P-8

P-9

P-106

International Symposium on Medicinal and Useful Plants in Pharmaceutical and Biomedical Sciences
between Japan - Nepal – Turkey - Italy
June 1-2, 2024, Kumamoto, Japan

Guidelines for Poster Presentation
Poster size: B0 Potrait, (1030 mm width x 1456 mm height)
Venue: Conference Room of Miyamoto Memorial Hall
Posting Date and time: June 2 (Sun.), 12:00 – 17:00 (Posters should be set up by 12:00)

Symposium Session II. (Continue)
Botanist Zone & Biomedical
S-13

14:00 – 14:30

S-14

14:30 – 15:00

15:00 – 15:30
S-15

15:30 – 16:00

S-16

16:00 – 16:30

S-17

16:30 – 17:00

17:00

Epidemic Risk Assessment of Mosquito-Borne Infectious Diseases andPotential Use of Plants for Mosquito Control
Prof. Dr. Mayuko Yonejima
Faculty of Humanities and Social Sciences
Kumamoto University, Japan
Biologically Active Triterpenes Found by Screening and Derivatization
Prof. Dr. Mikako Fujita
Department of Medicinal and Biological Chemistry
Kumamoto University, Japan
Coffee Break
Unveiling Nature’s Pharmacy: Habitat Suitability Modeling for
Medicinal Plants Using Machine Learning TechniquesProf. Dr. Aedla Raju
1
Vishnu Educational Development and Innovation Centre (VEDIC), Aziz
Nagar, Moinabad, Hyderabad, Telangana, India
2
BVRIT HYDERABAD College of Engineering for Women (BVRITH),
Bachupally, Nizampet, Hyderabad, India.
Zoom Online Invited Lecture-4
Turkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1
Release and Accelerate Cell Apoptosis
Mr. Wright Ofotsu Amesimeku
Department of Microbiology
Kumamoto University, Japan
Medicinal Plants an Important Resource of Nepal for Future Generation
Prof. Dr. Sangeeta Rajbhandary
Central Department of Botany
Tribhuvan University, Nepal
Zoom Online Invited Lecture-5

Closing remarks
Prof. Takashi Watanabe
School of Pharmacy, Kumamoto University, Japan7