The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 1

C 会場  Planned Symposium 1

Hall C

Lectures

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

日韓合同シンポジウムー FAOPS2019に向けてー
心血管の機能と病態におけるミトコンドリア恒常性制御

Japan-Korea Joint Symposium – Towards FAOPS2019 –Mitochondrial homeostasis in cardiovascular function and disease

Symposia

オーガナイザー・Organizer：
西田 基宏（自然科学研究機構岡崎統合バイオサイエンスセンター（生理学研究所）心循環シグナル研究部門）
Motohiro Nishida (Div Cardiocirc Signal, Okazaki Inst Integr BioSci (Natl Inst Physiol Sci), NINS)Jin Han (Dept Physiol, Col Med, CMDC, Inje Univ)

1PS01C1-1

Cardiac mitochondrial defects in the sepiapterin reductase KO mouse
Jin Han, Hyoungkyu Kim, Taehee Ko, Nari Kim, Sung-Ryul Lee, Kyungsoo Ko,
Byoungdoo Rhee
ミトコンドリアtRNA修飾によるタンパク質恒常性の維持機構○魏 范研1，鈴木 勉2，富澤 一仁1
1熊大・院医・分子生理，2東京大学大学院工学系研究科化学生命工学専攻

Regulation of cellular protein homeostasis by mitochondrial tRNA modification
Fan-Yan Wei1, Tsutomu Suzuki2, Kazuhito Tomizawa1

1Dept Mol Physiol, Faculty of Life Sci, Kumamoto Univ, Kumamoto, Japan, 2Dept Chem Biotech, Sch
Engineering, Univ Tokyo, Tokyo, Japan

1PS01C1-3

平滑筋Ca2+シグナルにおけるミトフュージン2の生理機能○山村 寿男，川崎 桂輔，稲垣 奏，鈴木 良明，今泉 祐治
名市大・院薬・細胞分子薬効解析

Physiological functions of mitofusin 2 on cytosolic Ca2+ signaling in smoothmuscle cells
Hisao Yamamura, Keisuke Kawasaki, Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi
Dept Mol Cell Pharmacol, Grad Sch Pharmaceut Sci, Nagoya City Univ, Nagoya, Japan

1PS01C1-4

心筋ミトコンドリア動態のレドックス制御機構○西田 基宏1,2,3,4
1 岡崎生理研統合バイオ・心循環，2 九州大・院薬・創薬育薬研究施設，3 総研大・生理科学専攻，4JST さ

きがけ「疾患代謝」

Mechanism underlying redox regulation of cardiac mitochondria dynamics
Motohiro Nishida1,2,3,4

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Posters Day 1

1PS01C1-2

Posters Day 2

Dept Physiol, Col Med, CMDC, Inje Univ, Busan, Korea

2Dept Transl Pharm Sci, Grad Sch Pharm Sci, Kyushu Univ, Fukuoka, Japan, 3Dept Physiol,
SOKENDAI, Okazaki, Japan, 4JST, PRESTO

Aims & Scope
Maintenance of organellar functions has been now attracted attention as a new strategy for the prevention ofcardiovascular diseases. Especially, mitochondria plays pivotal roles including energy production, Ca2+ handling, andautophagy. Mitochondrial dysfunction causes various muscular refractory diseases. Mitochondrial dynamics are precisely
regulated by various environmental factors, such as hypoxia, oxidative stress (including electrophilic environmental
pollutants) and hyperglycemia, and failure of mitochondrial quality control will increase the risk of cardiovascular diseases.
In this symposium, we will introduce cutting-edge researches on the molecular mechanisms underlying controlling
mitochondrial quality, and consider new strategies for the prevention or treatment of cardiovascular diseases.
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Posters Day 3

1Div Cardiocirc Signal, Okazaki Inst Integr BioSci (Natl Inst Physiol Sci), NINS, Okazaki, Japan,

第94回⽇本⽣理学会⼤会

企画シンポジウム 2

A 会場  Planned Symposium 2

Hall A

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40【株式会社ミユキ技研協賛】
てんかん病態の基礎と臨床のtranslatability：オシロロジーからのアプローチ【Supported by Miyuki Giken Co., Ltd.】The translatability between basic and clinical studies for the pathophysiology of epilepsy:
approach from oscillology
オーガナイザー・Organizer：
長峯 隆（札幌医科大学医学部 神経科学講座）
Takashi Nagamine (Department of Systems Neuroscience, School of Medicine, Sapporo Medical University)
池田 昭夫（京都大学大学院医学研究科 てんかん・運動異常生理学講座）
Akio Ikeda (Dept Epilepsy Movement Disorders Physiol, Kyoto Univ Grad Sch Med)

1PS02A2-1

今日のてんかん病態の理解と未解決の問題点○池田 昭夫
京都大・院医・てんかん運動異常

Overview of current state of epilepsy and unsolved problems
Akio Ikeda
Dept Epilepsy Movement Disorders Physiol, Kyoto Univ Grad Sch Med, Kyoto, Japan

1PS02A2-2

基礎研究からのアプローチー Scn1a遺伝子変異ラットを用いた高体温感受性痙攣の電気
生理学的研究ー○大守 伊織1，小林 勝弘2
1岡山大・院教育・特別支援教育，2岡山大・院医歯薬・発達神経病態学

Approach from basic and molecular study -Electrophysiological study ofhyperthermia-induced seizures in Scn1a mutant ratsIori Ohmori1, Katsuhiro Kobayashi2

1Dept Special Needs Education, Okayama Univ Grad Sch Edu, Okayama, Japan, 2Dept Child
Neurol, Okayama Univ Grad Sch Med Dent Pharm Sci, Okayama, Japan

1PS02A2-3

てんかん原性と関連ネットワーク：臨床神経生理学的アプローチ○松本 理器1，小林 勝哉1，菊池 隆幸2，吉田 和道2，國枝 武治3，池田 昭夫4
1京都大・院医・臨床神経学，2京都大学大学院医学研究科脳神経外科学，3愛媛大学大学院医学系研究科脳神経外科学，4京都大学大学院医学研究科てんかん・運動異常生理学講座

Epileptogenicity and related network: Approach from clinical neurophysiology

Riki Matsumoto1, Katsuya Kobayashi1, Takayuki Kikuchi2, Kazumichi Yoshida2,
Takeharu Kunieda3, Akio Ikeda4

1Dept Neurol, Kyoto Univ Grad Sch Med, Kyoto, Japan, 2Dept Neurosurgery, Kyoto Univ Grad Sch
Med, Kyoto, Japan, 3Dept Neurosurgery, Ehime Univ Grad Sch Med, Toon, Japan, 4Dept Epilepsy
Movement Disorders Physiol, Kyoto Univ Grad Sch Med, Kyoto, Japan

1PS02A2-4

脳の動的活動状態に埋め込まれた数学的構造の発見：理論と応用○津田 一郎，行木 孝夫
北大・理学研究院・数学部門

Finding mathematical structures in the brain dynamics: theory and its
application
Ichiro Tsuda, Takao Namiki
Dept Math, Grad Sch Sci, Hokkaido Univ, Sapporo, Japan

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The 94th Annual Meeting of the Physiological Society of Japan

Symposia

Epilepsy is one of the common disorders of the central nervous system, and neurons produce extraordinarily hyperexcitable
activity and clinically epileptic seizures occurred. It is caused by either increased excitation or decreased inhibition
depending on the various causes, and thus the treatment regimen also may depend on it. Both neurons and glia generates
even very high frequency- and infraslow activity respectively which makes the analysis of physiological data muchcomplicated. Since clinical neurophysiological data have been obtained by invasive EEG and by microelectrodes, a directcomparison between clinical situation and animal study is more plausible and translatability between the two is one of themost important approaches to solve the clinical and fundamental problems in epilepsy. In this symposium, the following
different approaches are introduced. 1) Overview of current state of epilepsy and unsolved problems, 2) Approach frombasic and molecular studies, 3) Approach from clinical neurophysiology, 4) Approach from mathematical analysis andmodeling. Upon those translatable approaches, it is expected that both normal cortical function and epileptic symptoms
may share the similar and dissimilar spectrum of physiological property as well as genetic property. It is also expected thattheoretical analysis of epileptic neurophysiological property and its subsequent modeling may help establish conceptual
basic principle and common framework of epileptic abnormality.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

企画シンポジウム 3

B 会場  Planned Symposium 3

Hall B

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

生理学におけるメカノバイオロジーのインパクト

The impact of mechanobiology in physiology
オーガナイザー・Organizer：
曽我部 正博（名古屋大学大学院医学系研究科 メカノバイオロジー・ラボ）
Masahiro Sokabe (Mechanobiology Lab, Nagoya Univ Grad Sch Med)

1PS03B2-1

接着斑において細胞骨格で制御される機械受容チャネルのメカノトランスダクション○曽我部 正博
名古屋大・院医・メカノバイオ

Mechanotransduction by cytoskeleton-regulated MS channels at focal
adhesions
Masahiro Sokabe
Mechanobiology Lab, Nagoya Univ Grad Sch Med, Nagoya, Japan

1PS03B2-2

血流センシングと血管の生理・病理○山本 希美子1，安藤 譲二2
1東大・院医・システム生理，2獨協医大・医・生体医工

Blood-flow sensing mechanism and their role in vascular physiology andpathology
Kimiko Yamamoto1, Joji Ando2

1System Physiol, Grad Sch Med, Univ Tokyo, Japan, 2Biomed Eng, Dokkyo Med Univ, Japan

1PS03B2-3

骨恒常性とメカノバイオロジー○中島 友紀1,2,3
1医科歯科大・院医歯学・分子情報，2AMED-CREST，3JSTさきがけ

Bone homeostasis and mechano-biology
Tomoki Nakashima1,2,3

1Dept Cell Signaling, Tokyo Medical and Dental Univ, Tokyo, Japan, 2AMED-CREST, Tokyo, Japan,
3JST, Tokyo, Japan

1PS03B2-4

遺伝子発現を制御するメカノトランスダクション○小椋 利彦東北大・加齢研・神経機能情報

Mechanotransduction and transcriptional control of gene expression
Toshihiko Ogura
Dept Dev Neurobiol, IDAC, Tohoku Univ Sendai, Japan

Aims & Scope
Mechanobiology is an emerging interdisciplinary field aiming at understanding roles and mechanisms underlying the actionof forces in organisms. Over the past decade mechanobiology has unveiled that not only specialized mechanosensory cells
including inner ear hair cells and baroreceptors, but also virtually all types of cells are equipped with a variety ofmechanosensing machineries which regulate fundamental cell functions such as cell cycle, proliferation, differentiation,
apoptosis, shape and migration. Furthermore, molecular identification of a variety of cell mechanosensors made it possible
to study their mechanotransduction processes using cutting edge technologies. These achievements have promoted
mechanobiology as a fundamental discipline across life sciences. One of the pressing issues in mechanobiology is tounderstand detailed molecular and biophysical mechanisms underlying the cell mechano-sensing and -signaling that leadto physiological and pathological responses. This symposium focuses on biophysical mechanisms of tension/shear stresssensing, and biochemical mechanisms of bone/muscle metabolism driven and/or modulated by mechanical stresses.
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The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 4

A 会場  Planned Symposium 4

Hall A

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

遺伝学と生理学の融合 −疾患研究から迫る分子機能の理解−

From genetics to physiology:
for understanding molecular functions and disease mechanisms

Symposia

オーガナイザー・Organizer：
才津 浩智（浜松医科大学医学部医学科 医化学講座）
Hirotomo Saitsu (Dept Biochem, Hamamatsu Univ, Sch Med)秋田 天平（浜松医科大学医学部医学科 神経生理学講座）
Tenpei Akita (Dept Neurophysiol, Hamamatsu Univ Sch Med)

2PS04A1-1

次世代シークエンス解析によるヒト疾患を引き起こす原因遺伝子（分子）の同定○才津 浩智浜松医科大学・医化学

Next-Generation Sequencing uncovers molecules essential for humanphysiology
Hirotomo Saitsu
Dept Biochem, Hamamatsu Univ, Sch Med, Hamamatsu, Japan

2PS04A1-2

神経K+-Cl− 共輸送体KCC2の両アレル変異による軽度機能低下が遊走性焦点発作を伴う
重篤な発達遅滞の原因となる

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Tenpei Akita1, Hirotomo Saitsu2, Miho Watanabe1, Naomichi Matsumoto3,
Atsuo Fukuda1

1Dept Neurophysiol, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Biochem, Hamamatsu
Univ Sch Med, Hamamatsu, Japan, 3Dept Hum Genet, Yokohama City Univ Grad Sch Med,
Yokohama, Japan

2PS04A1-3

てんかん関連リガンド-受容体LGI1-ADAM22：疾患原因変異から分子機能・治療戦略の理解へ○深田 優子
生理研・生体膜

Epilepsy-related ligand-receptor, LGI1 and ADAM22: from disease-causing
mutations to molecular functions and therapeutic strategies
Yuko Fukata

Posters Day 2

Mild functional impairment of neuronal K+-Cl− cotransporter KCC2 by biallelicmutations causes migrating focal seizures and severe developmental delay

Posters Day 1○秋田 天平1，才津 浩智2，渡部 美穂1，松本 直通3，福田 敦夫11浜松医大・医・神経生理学，2浜松医大・医・医化学，3横浜市大・医・遺伝学

2PS04A1-4

MIRAGE症候群：SAMD9変異とモノソミー 7のミステリー○鳴海 覚志
国立成育医療研究セ・分子内分泌

MIRAGE syndrome: a mystery of SAMD9 mutations and acquired monosomy 7
Satoshi Narumi
Dept Mol Endocrinol, Natl Res Inst Child Health & Dev, Tokyo, Japan

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Posters Day 3

Membrane Physiology, NIPS, Okazaki, Japan

第94回⽇本⽣理学会⼤会

Aims & Scope
Recent advances in next-generation sequencing (NGS) technology enable us to screen mutations in all the genes at once,
revealing pathogenic mutations in many human disorders. This “forward genetics” in humans uncovers the genes essential
for normal physiological functions. However, critical gaps remain in our understanding of how identified mutations affectour physiology. In this symposium, four speakers from genetics and physiology show their attempts to fill the gaps byreviewing the advantages of NGS and its recent applications (Saitsu), by reporting new examples of gene mutations causing
migrating focal seizures and severe developmental delay (Akita) and a multisystem disorder due to growth restriction andgeneralized organ hypoplasia (Narumi), and by providing a possible therapeutic option ameliorating the seizure
susceptibility due to a single gene mutation (Fukata). This symposium will provide a novel physiological insight intomolecular functions, indicating the importance of close collaboration between geneticists and physiologists.

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企画シンポジウム 5

B 会場  Planned Symposium 5

Hall B

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

日本薬理学会連携シンポジウム
光遺伝学の新展開〜非興奮性細胞への活用と新ツールの開発

Symposia

Joint Symposium with the Japanese Pharmacological Society
Innovation of optogenetics 〜 application to non-excitable cells anddevelopment of the new tools
オーガナイザー・Organizer：
日比野 浩（新潟大学大学院 医歯学総合研究科）
Hiroshi Hibino (Niigata University School of Medicine)山崎 良彦（山形大学 医学部）
Yoshihiko Yamazaki (Dept Physiol, Yamagata Univ Sch Med)

内耳の非興奮性細胞の光操作を駆使した変動性難聴モデル動物の確立
野 浩1

Reconstitution of short-term hearing fluctuation by application of the
optogenetic approach to non-excitable, non-glial cells in the inner ear

Fumiaki Nin1, Mitsuo Paulo Sato2, Taiga Higuchi1, Kenji F Tanaka3 , Hiroshi Hibino1
1Dept Mol Physiol, Niigata Univ Sch Med, Niigata, Japan, 2Dept Otorhinolaryngol, Faculty Med,
Kindai Univ, Osakasayama, Japan, 3Dept Neuropsychi, Sch Med, Keio Univ, Tokyo, Japan

2PS05B1-2

オリゴデンドロサイトの膜電位変化による有髄線維の軸索伝導と出力先シナプス伝達に対する修飾効果○山崎 良彦山形大・医・生理

Modulatory effects of the changes in membrane potential of oligodendrocytes
on axonal conduction and synaptic responses in the hippocampus
Yoshihiko Yamazaki
Dept Physiol, Yamagata Univ Sch Med, Yamagata, Japan

In vitroおよびin vivoにおける光活性化アデニル酸シクラーゼの利用

Posters Day 2

2PS05B1-3○小山 隆太，池谷 裕二
東京大・院薬・薬品作用The use of photoactivated adenylyl cyclase (PAC) in vitro and in vivo
Ryuta Koyama, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, Japan

2PS05B1-4

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Posters Day 1○任 書晃1，佐藤 パウロ 満雄2，樋口 大河1，田中 謙二3 ,1新潟大・医・分子生理，2近畿大・医・耳鼻咽喉科，3慶應大・医・精神神経オルガネラ・オプトジェネティクス−細胞内Ca2+ダイナミクスの光制御○五十嵐 敬幸1，吉川 彩香2，浅野 豪文3，今野 歩4，櫻木 繁雄2，石塚 徹2，平井 宏和4，
八尾 寛1,2
1 東北大・院医・神経細胞制御学，2 東北大・院生命・生命，3 東京医科歯科大・院医歯学総合・細胞生物学，4群馬大学・院医・脳神経再生医学

Organelle-optogenetics –Intervention of intracellular Ca2+ dynamics by light–
Hiroyuki Igarashi1, Ayaka Yoshikawa2, Toshifumi Asano3, Ayumu Konno4,
Shigeo Sakuragi2, Toru Ishizuka2, Hirokazu Hirai4, Hiromu Yawo1,2

1Dept Physiol Pharmacol, Grad Sch Med, Tohoku Univ, Sendai, Japan, 2Dept Dev Biol Neurosci,

Grad Sch Life Sci, Tohoku Univ, Sendai, Japan, 3Dept Cell Biol, Grad Sch Med Den Sci, Tokyo Med
and Den Univ, Tokyo, Japan, 4Dept Neurophysiol Neural Repair, Grad Sch Med, Gunma Univ,
Maebashi, Japan

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Posters Day 3

2PS05B1-1

第94回⽇本⽣理学会⼤会

2PS05B1-5ゲノムの光操作技術○佐藤 守俊東大・院総合文化

Optical control of the genome
Moritoshi Sato
Grad Sch Arts and Sciences, Univ Tokyo, Tokyo, Japan

Aims & Scope
Optogenetics has been used in a variety of field in neuroscience for these ten years and clarified the mechanisms
underlying numerous physiological phenomena in the brain. In this approach, particular neuronal cell types are geneticallyengineered to harbor light-gated cation or anion channels. Optical stimulation of the brain activates or inactivates thesecells by inducing ionic flows, which results in selectively modulating the function of certain network. Recent technologies
have targeted myoblasts as well and succeeded in controlling their differentiation. Besides these studies for excitable cells,
advances of the optogenetics have allowed the researchers to express the channels in non-excitable compartments such asepithelial-like tissue and glial cells. Furthermore, intracellular signal transductions as well as genomic elements can be
currently analyzed with novel light-sensitive tools to investigate cellular physiological architectures. In this symposium, thespeakers will show these achievements and state-of-the-art techniques and discuss the application of the optogenetic
approaches to open the next generation of life science.

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企画シンポジウム 6

C 会場  Planned Symposium 6

Hall C

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

細胞代謝-機能連関研究の最前線

Recent advances in cellular metabolism-function coupling
オーガナイザー・Organizer：
鈴木 優子（浜松医科大学 医生理学講座）
Yuko Suzuki (Dept of Medical Physiology, Hamamatsu University School of Medicine)

2PS06C1-1

Symposia

田久保 圭誉（国際医療センター研究所 生体恒常性プロジェクト）
Keiyo Takubo (Dept of Stem Cell Biology, Res Institute, National Center for Global Health and Medicine)

造血幹細胞の機能発揮に必要な代謝シグナル○田久保 圭誉
国際医療研セ研・生体恒常性プロ

Metabolic regulation of hematopoietic stem cell function
Keiyo Takubo
Dept Stem Cell Biol, Research Institute, National Center for Grobal Health and Medicine, Tokyo,
Japan

2PS06C1-2

多能性幹細胞の代謝と心臓再生医療○遠山 周吾慶應義塾大・医・循環器内科

Posters Day 1

Manipulation of pluripotent stem cell metabolism for cardiac regenerative
medicine
Shugo Tohyama
Dept Cardiol, Keio Univ Sch Med, Tokyo, Japan

2PS06C1-3

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アポトーシスにおける細胞内ATPダイナミクスのイメージング○今村 博臣京大・生命科学・高次生体統御

Imaging of intracellular ATP dynamics during apoptosis

Posters Day 2

Hiromi Imamura
Dept Funct Biol, Grad Sch Bio, Kyoto Univ, Kyoto, Japan

2PS06C1-4

GTPセンサーの発見○千田 俊哉1，竹内 恒2，千田 美紀1，佐々木 敦朗3
1高エネ機構・物構研・構造生物，2産総研創薬分子プロファイリング研究セ，3シンシナティ大Discovery of a GTP sensor with a structural reverse genetic approach
Toshiya Senda1, Koh Takeuchi2, Miki Senda1, Atsuo T Sasaki3
Cincinnati Col Med, Ohio, USA

Aims & Scope“The Warburg effect” is a well-known phenomenon that cancer cells metabolize glucose to generate the energy in a
distinct manner from that of normal cells, which was reported by Otto Warburg in 1924. Warburg found that unlike mostnormal tissues, cancer cells tend to “ferment” glucose into lactate even in the presence of sufficient oxygen to support
mitochondrial oxidative phosphorylation. Originating from the reports that oncogenic mutations are responsible for themodification in the uptake of nutrients and cellular metabolism, recent excellent studies on the maintenance of the stem cellhomeostasis, the advantage of unique metabolic properties of cardiomyocyte for cardiac regenerative therapy, the imaging
of intracellular ATP distribution in podocyte, and a newly identified intracellular GTP sensor for metabolism andtumorigenesis will be discussed. Advanced understandings of the mechanistic links between cellular metabolism and cellfunction such as growth, differentiation, etc. may ultimately lead to better understanding of the logic of life.
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Posters Day 3

1SBRC, IMSS, KEK, Tsukuba, Japan, 2Molprof, AIST, Tokyo, Japan, 3Dept Internal Medicine, Univ

第94回⽇本⽣理学会⼤会

企画シンポジウム 7

B 会場  Planned Symposium 7

Hall B

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30【新学術「オシロロジー」共催】

パーキンソン病の生理と臨床【Co-sponsored by the MEXT “Oscillology”】

Parkinson’s disease: from basic neuroscience to clinical application
オーガナイザー・Organizer：
美馬 達哉（立命館大学大学院 先端総合学術研究科）
Tatsuya Mima (The Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University)
南部 篤（生理学研究所 生体システム研究部門）
Atsushi Nambu (Natl Inst Physiol Sci)

2PS07B2-1

GABA interneurons generate oscillations in the dopamine-depleted striatum
Constance Hammond
INMED, INSERM, Marseille, France

2PS07B2-2

中脳ドーパミン神経シグナルの多様性○松本 正幸筑波大・医学医療・認知行動神経

Multiple signals transmitted by midbrain dopamine neurons
Masayuki Matsumoto
Lab Cogn & Behav Neurosci, Fac Med, Univ Tsukuba, Japan

2PS07B2-3

D1ドーパミン受容体を介する神経伝達は運動情報の伝達と運動の発現に不可欠である○笹岡 俊邦1,2,3，佐藤 朝子2,3，知見 聡美4，大久保 直3，前島 純3，新井 慧3，砂山 智子2,5，
小田 佳奈子1，酒井 清子1，前田 宜俊1，神保 幸弘1，中尾 聡宏1，佐藤 俊哉1,3，
藤澤 信義1，南部 篤4
1新潟大・脳研，2基生研，3北里大・医，4生理研，5東大院

Dopamine D1 receptor-mediated transmission maintains information flow
through the cortico-striato-entopeduncular direct pathway to release
movements

Toshikuni Sasaoka1,2,3, Asako Sato2,3, Satomi Chiken4, Tadashi Okubo3,
Jun Maeshima3, Satoshi Arai3, Tomoko Sunayama2,5, Kanako Oda1, Seiko Sakai1,
Yoshitaka Maeda1, Yukihiro Jinbo1, Satohiro Nakao1, Toshiya Sato1,3,
Nobuyoshi Fujisawa1, Atsushi Nambu4
1Brain Res Inst Niigata Univ, Niigata, 2Natl Inst Basic Biol, 3KItasato Univ Sch Med, 4Natl Inst
Physiol Sci, 5Grad Sch Art Sci, Univ Tokyo, Japan

2PS07B2-4

ジストニアにおける視床運動核の神経振動○村瀬 永子1，松橋 眞生2，前田 裕仁3，平林 秀裕41京都医療センター・神経内科，2京都大学・教育研究推進センター，3神戸大学・災害・救急医学分野，
4奈良医療センター・脳神経外科

Oscillatory neurons of the motor thalamus in dystonia

Nagako Murase1, Masao Matsuhashi2, Yuji Maeda3, Hidehiro Hirabayashi4
1Dept Neurol, NHO Kyoto medical Center, Kyoto, Japan, 2Research and Educational Unit of Leaders

for Integrated Medical System, Kyoto Univ, Kyoto, Japan, 3Dept Emergency and Critical Care
Medicine, Kobe Univ Grad Sch Med, Kobe, Japan, 4Dept Neurosurgery, National Hospital
Organization Nara Medical Center, Nara, Japan

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Symposia

Since the introduction of the “direct and indirect pathways model” of the basal ganglia in early 1990s, there has been
tremendous progress in understanding the normal functions of the basal ganglia and pathophysiology of movement
disorders. The basic knowledge has helped new development of the therapy of basal ganglia disorders, such as Parkinson’s
disease and dystonia. In the present symposium, we will invite basic and clinical neuroscientists, summarize recent progressof the basal ganglia functions, including the dopamine and higher brain functions, and discuss future therapeutic strategies
for basal ganglia disorders.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

教
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第94回⽇本⽣理学会⼤会

企画シンポジウム 8

C 会場  Planned Symposium 8

Hall C

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

日台合同シンポジウムー FAOPS2019に向けて
イオンチャネルの生理・病態生理

Japan-Taiwan Joint Symposium– Towards FAOPS2019 –Ion channels in physiology and patho-physiology
オーガナイザー・Organizer：
樽野 陽幸（京都府立医科大学大学院医学研究科 細胞生理学）
Akiyuki Taruno (Dept Mol Cell Physiol, Grad Sch Med, Kyoto Pref Univ Med)

Pei-Chun Chen (Dept Physiol, Grad Sch Basic Med, Natl Cheng Kung Univ)

2PS08C2-1

CALHMチャネルによる味覚の神経伝達○樽野 陽幸1，丸中 良典1,21京都府立医大・院医・細胞生理，2京都府立医大・院医・バイオイオノミクス

Neurotransmission of taste mediated by calcium homeostasis modulator ion
channels
Akiyuki Taruno1, Yoshinori Marunaka1,2

1Dept Mol Cell Physiol, Grad Sch Med, Kyoto Pref Univ Med, Kyoto, Japan, 2Dept Bio-Ionomics,
Grad Sch Med, Kyoto Pref Univ Med, Kyoto, Japan

2PS08C2-2

Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in
pancreatic β-cells
Pei-Chun Chen1, Yi Wu2, Show-Ling Shyng2

1Dept Physiol, Grad Sch Basic Med, Natl Cheng Kung Univ, Tainan, Taiwan, 2Dept Biochem and
Mol Biol, OHSU, USA

2PS08C2-3

少数の分子による嗅覚情報伝達チャネルの修飾○竹内 裕子，倉橋 隆
阪大・院・生命・生理

Modification of the olfactory transduction channel by small molecules
Hiroko Takeuchi, Takashi Kurahashi
Grad Sch Front Biosci, Osaka Univ, Japan

2PS08C2-4

Regulation of adult neurogenesis in the mouse SGZ by Kv1.1 potassium channel
Shi-Bing Yang
Inst Biomed Sci, Academia Sinica, Taipei, Taiwan

Aims & Scope
Towards the success of FAOPS 2019 in Japan, the Physiological Society of Japan (PSJ) has been organizing joint symposia
with FAOPS countries. Here, we would like to propose a joint symposium with the Chinese Physiological Society (CPS)(Taiwan). ThisCPS-PSJ joint symposium is focused on "ion channels in physiology and patho-physiology" and consists of 4
talks by 2 CPS speakers and 2 PSJ speakers.
Growing evidence has demonstrated that ion channels play important roles in health and diseases throughout our body.
Since ion channels mediate many physiological processes, malfunction of ion channels lead to diseases (a.k.a.
channelopathy). Thus, knowing ion channels involved in physiological systems and their regulatory mechanisms is crucial
for treating channelopathies. In this symposium, we would like to introduce recent advances in ion channel researches leadby Taiwanese and Japanese researchers. Taruno will talk about discovery of a novel ion channel that mediates
neurotransmission of tastes. Chen will present their work on concerted trafficking regulation of Kv2.1 and KATP channels byleptin in pancreatic β-cells. Takeuchi will introduce how the olfactory transduction channels are modified by small
molecules. And finally, Yang will discuss regulation of adult neurogenesis by Kv1.1 channel.
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H 会場  Planned Symposium 9

Hall H

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30【文部科学省 先端研究基盤共用促進事業 原子・分子の顕微イメージングプラットフォーム共催】

マスイメージング技術講習会

Lectures

企画シンポジウム 9【Co-sponsored by the MEXT National Program for Advanced Research Platforms

Symposia“Imaging Platform”】
Mass imaging technical workshop

オーガナイザー・Organizer：
瀬藤 光利（浜松医科大学国際マスイメージングセンター）
Mitsutoshi Setou (Intl Mass Imaging Ctr, Hamamatsu Univ Sch Med)山崎 文義（浜松医科大学国際マスイメージングセンター）
Fumiyoshi Yamazaki (Intl Mass Imaging Ctr, Hamamatsu Univ Sch Med)

2PS09H2-1

Improvements in MALDI imaging used to drive new frontiers of biologicalhypothesis testing

教
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○マイケル イースターリング
ブルカー・ダルトニクス株式会社

Improvements in MALDI imaging used to drive new frontiers of biologicalhypothesis testing
Easterling L Michael

2PS09H2-2

Rapid matrix-free molecular imaging of drugs and metabolites in tissues using
desorption electrospray ionization (DESI) mass spectrometry○パクストン タナイ，佐藤 太，寺崎 真樹
日本ウオーターズ

Rapid matrix-free molecular imaging of drugs and metabolites in tissues using
desorption electrospray ionization (DESI) mass spectrometry
Thanai Paxton, Futoshi Sato, Maki Terasaki

Posters Day 1

Bruker Daltonics, Inc., MA, USA

2PS09H2-3

Posters Day 2

Analytical and Measuring Instruments Division, Nihon Waters K.K., Tokyo, Japan

高空間分解能を実現するイメージング質量顕微鏡○緒方 是嗣島津製作所

Imaging mass microscopy for high special resolution analysis
Koretsugu Ogata
Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

ライフサイエンス分野におけるラベルフリーラマンイメージングついて

Posters Day 3

2PS09H2-4○中野 辰彦，にしかわ のりあき，でみず ひろし，ジェニファー ラミレス
サーモフィッシャーサイエンティフィック株式会社

Label-free raman imaging for life science application
Tatsuhiko Nakano, Noriaki Nishikawa, Hiroshi Demizu, Ramirez Jennifer
Thermo Fisher Scientific73第94回⽇本⽣理学会⼤会

2PS09H2-5

質量顕微鏡法による腹部大動脈瘤壁の解析○田中 宏樹1，財満 信宏2，海野 直樹3，浦野 哲盟1，瀬藤 光利4
1 浜松医科大学・医生理学，2 近畿大学農学部応用生命化学，3 浜松医科大学・血管外科，4 浜松医科大学・
細胞分子解剖学

Imaging mass spectrometry reveals a novel mechanism of abdominal aortic
aneurysm development

Hiroki Tanaka1, Nobuhiro Zaima2, Naoki Unno3, Tetsumei Urano1,
Mitsutoshi Setou4

1Dept Med Physiol, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Applied Biol Chem, Grad

Sch Agriculture, Kindai Univ, 3Div Vascular Surgery, Hamamatsu Univ Sch Med, Hamamatsu,
Japan, 4Dept Cell Mol Anat, Hamamatsu Univ Sch Med, Hamamatsu, Japan

2PS09H2-6

TOF-SIMSを用いた細胞内脂肪酸分布のイメージング○堀川 誠1,2
1浜松医科大・解剖学，2国際マスイメージングセンター

Intracellular imaging of fatty acids by using time-of-flight secondary ion mass
spectrometry
Makoto Horikawa1,2

1Dept Cell Mol Anat, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2International Mass Imaging

Center, Hamamatsu Univ Sch Med, Hamamatsu, Japan

Aims & Scope
This symposium is a joint symposium by Physiological Society of Japan and MEXT National Program for Advanced Research
Platforms “Imaging Platform”. Imaging Platform is comprised of Hakkaido University, Hamamatsu University of Medicine
and Hiroshima University, which have a wide variety of advanced imaging analysis equipment in various fields of study suchas biochemistry, material, environment, energy, and universe. In this symposium recent findings and technology of imaging
mass spectrometry, which is a core technology in Hamamatsu University of Medicine International Mass Imaging Center in
Imaging Platform, will be presented. We aim to develop human resources and imaging techniques through acquiring a
new technique, information sharing and discussion among user, researcher, student and engineer in academic andindustries.

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The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 10

B 会場  Planned Symposium 10

Hall B

Lectures

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50【新学術「先端バイオイメージング支援プラットフォーム」共催】

光バイオイメージングによる多階層的生理研究【Co-sponsored by the MEXT “Advanced bioimaging support”】

Optical bio-imaging to visualize the hierarchical physiology

Symposia

オーガナイザー・Organizer：
瀬藤 光利（浜松医科大学 細胞分子解剖学講座）
Mitsutoshi Setou (Dept Cell Biol Anat, Hamamatsu Univ Sch Med)和氣 弘明（神戸大学大学院医学研究科 システム生理学分野）
Hiroaki Wake (Div System Neurosci, Kobe Univ Grad Sch Med)

2PS10B3-1

中枢神経系免疫システムの可視化○和氣 弘明1,2,3
1神戸大・院医・システム生理，2自然科学研究機構 生理学研究所，3さきがけ、科学技術振興機構

Visualization of immune system in brain

教
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Hiroaki Wake1,2,3

1Dept Neurophysiol, Grad Sch Med, Univ Kobe, JAPAN, 2Dept Homeostatic development, NIPS,
NINS, JAPAN, 3PRESTO, JST

2PS10B3-2

超解像イメージングによるシナプス伝達制御機構の解析○矢尾 育子Dept Optical Imaging, Hamamatsu Univ Sch Med, Hamamatsu, Japan

2PS10B3-3

マスイメージングにより明らかになった翻訳後修飾変異マウス脳における神経伝達物質の変化○瀬藤 光利1,2
1浜松医大・分子解剖，2国際マスイメージングセンター

Mass spectrometry imaging revealed the alteration of the neurotransmitters inbrain tissue sections of post-translational modification mutant mouse
Mitsutoshi Setou1,2

1Dept Cell Biol Anat, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2International Mass Imaging

Center, Hamamatsu Univ Sch Med, Hamamatsu, Japan

2PS10B3-4

Cruising inside cells○宮脇 敦史理研BSI

Posters Day 2

Ikuko Yao

Posters Day 1

浜松医大・光イメージング

Super resolution imaging of synaptic site to analyze the transmission regulation

Atsushi Miyawaki
RIKEN BSI, Saitama, Japan

Aims & Scope
Research into physiological phenomena has taken a leap forward by recent advanced optical bio imaging techniques.
Traditionally, physiological phenomena including cell division, cell function, molecular transport and cell death weredetected by biochemical methods. However, this information lacked high resolution spatial or temporal information. Using
recent bio imaging techniques, both spatial and temporal information can be integrated across the molecular, cellular andsystems levels that allow us to further investigate the hierarchical interaction of organ systems. In this session, we will discuss
the current and potential future state of imaging techniques, and will further discuss what information can be revealed by
the visualization of single molecules, lipid to cell function, and system physiology.
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Posters Day 3

Cruising inside cells

第94回⽇本⽣理学会⼤会

企画シンポジウム 11

E 会場  Planned Symposium 11

Hall E

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50

JPS編集委員会企画シンポジウム
新たな段階を迎えたJPSの展開

JPS in the next stage; its future direction
オーガナイザー・Organizer：
石川 義弘（横浜市立大学大学院 医学研究科）
Yoshihiro Ishikawa (Cardiovasc Res Inst, Yokohama City Univ)

2PS11E3-1

メガジャーナルのパイオニアPLOS ONEについて○横山 詩子，石川 義弘
横浜市大・医・循環制御医学

PLOS ONE as a pioneer of mega journals
Utako Yokoyama, Yoshihiro Ishikawa
Cardiovasc Res Inst, Yokohama City Univ, Yokohama, Japan

2PS11E3-2

国際神経内分泌学会の公式機関誌であるジャーナルオブニューロエンドクリノロジーについて○上田 陽一
産業医大・医・第1生理学

The Journal of Neuroendocrinology as an official journal of International
Neuroendocrine Federation
Yoichi Ueta
Dept Physiol, Sch Med, Univ Occup Environ Health, Kitakyushu, Japan

2PS11E3-3

生理学会英文雑誌の次なる課題は何か○石川 義弘
横浜市立大・院医・循環制御

What is the next step for JPS
Yoshihiro Ishikawa
CVRI, Yokohama City Univ Sch Med, Yokohama, Japan

Aims & Scope
The Journal of Physiological Sciences, the official English journal of the Physiological Society of Japan, was established morethan 60 years ago. Its impact factor has reached 2.165, and thus the Journal has already established its position as a leading
physiology journal in Asia. In this symposium, Youichi Ueta will introduce the journal activity of the Journal of
Neuroendocrinology. Utako Yokoyama will introduce PlosOne, which is an open access journal, because JPS is going to be
an open access journal in the near future. Yoshihiro Ishikawa will introduce JPS in the next stage. We will also instruct young
scientists how to publish their work in these journals.

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H 会場  Planned Symposium 12

Hall H

Lectures

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50

タウリンの多彩な生理機能

Joint Symposium with Society for Taurine Research
Diverse physiological actions of taurine
オーガナイザー・Organizer：
村上 茂（福井県立大学 生物資源学部）
Shigeru Murakami (Dept Biosci, Fukui Pref Univ)
栃谷 史郎（福井大学 子どものこころの発達研究センター）
Shiro Tochitani (Res Cent Child Mental Dev, Univ Fukui)

2PS12H3-1

タウリンは脂肪組織の炎症反応を抑制することによりマウスにおいて抗肥満作用を示す

Symposia

企画シンポジウム 12○村上 茂
福井県立大・生物資源

Taurine ameliorates obesity by regulating adipocyte inflammatory response inmice
Shigeru Murakami
Dept Biosci, Fukui Pref Univ, Fukui, Japan

2PS12H3-2

タウリンとBCAAの摂取が運動後の筋損傷に及ぼす影響
○大森 肇

教
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筑波大・体育系・運動生化学

Faculty Health Sport Sci, Univ Tsukuba, Tsukuba, Japan

2PS12H3-3

母体由来タウリンはマウス発生期大脳皮質神経系前駆細胞の内在的性質を制御する○栃谷 史郎福井大・子どものこころ

Maternally-derived taurine regulates the intrinsic properties of the neuralprogenitors in the mouse developing neocortex
Shiro Tochitani
Res Cent Child Mental Dev, Univ Fukui, Fukui, Japan

2PS12H3-4

タウリン欠乏は大脳皮質感覚野錐体細胞におけるポストシナプスのGABAA 受容体数を減少させる。
○細井 泰志1，秋田 天平2，渡部 美穂2，武藤 弘樹2，宮嶋 裕明1，福田 敦夫2
1浜松医科・医・第一内科，2浜松医大・医・神経生理

Taurine depletion reduces postsynaptic GABAA receptors in layer 2/3 pyramidal
neurons of the somatosensory cortex
Yasushi Hosoi1, Tenpei Akita2, Miho Watanabe2, Hiroki Mutoh2,
Hiroaki Miyajima1, Atsuo Fukuda2

1First Dept Intern Med, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Neurophysiol,

Hamamatsu Univ Sch Med, Hamamatsu, Japan

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Posters Day 3

Hajime Ohmori

Posters Day 2

Posters Day 1

Effect of taurine and BCAA intake on muscle damage after exercise

第94回⽇本⽣理学会⼤会

Aims & Scope
Taurine is a sulfur-containing β–amino acid with various physiological functions including osmoregulation, antioxidant
effects, and protein stabilization. Taurine also functions as ligands for GABAA receptors and glycine receptors. However,many researchers in the field of physiology are unfamiliar with taurine. In this symposium, we would like to introduce thebasics of taurine to the audience and highlight the recent progresses in the studies of taurine in various physiological fields.
Dr. Murakami will show us the functions of taurine in lipid metabolism and obesity. Dr. Omori will explain about the effectsof taurine in exercise and muscle functions. Drs. Tochitani and Hosoi will refer to the functions of taurine in the various
events of neural development. We hope that the audience would realize the diverse functions of taurine and its potentials
in preventive and therapeutic medicine.

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The 94th Annual Meeting of the Physiological Society of Japan

企画シンポジウム 13

B 会場  Planned Symposium 13

Hall B

Lectures

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50【新学術「オシロロジー」共催】

非線形・振動現象の新展開【Co-sponsored by the MEXT “Oscillology”】

Nonlinear and oscillatory phenomenon in neurophysiology

Symposia

オーガナイザー・Organizer：
虫明 元（東北大学大学院 医学系研究科）
Hajime Mushiake (Dept Physiol, School of Medicine, Tohoku Univ)
森田 賢治（東京大学大学院教育学研究科 身体教育学コース）
Kenji Morita (Physical and Health Education, Grad Sch Edu, Univ Tokyo)

3PS13B1-1

神経系発振ステートを制御するアストロサイト活動の解明
○松井 広
教
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東北大・院医・新医学領域創生

Glial regulation of neuronal oscillations
Ko Matsui
Div Interdisciplinary Med Sci, Grad Sch Med, Tohoku Univ, Sendai, Japan

3PS13B1-2

目的指向型行動における腹側線条体カルシウム振動の役割

1Dept Neuropsychiatry, Sch Med, Keio Univ, Tokyo, Japan, 2JSPS Research Fellow, Tokyo, Japan,
3Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

3PS13B1-3神経細胞のResonance特性に関わるイオンチャネルの解析○橋本 浩一1，槇殿 佳子1，中山 寿子1，山崎 美和子2，宮崎 太輔2，小林 和人3，
渡辺 雅彦2，狩野 方伸4，崎村 建司5
1広大・医歯薬保健学・神経生理学，2北大・院医・解剖，3福島県立医科大・生体情報伝達研究所・生体機能研究部門，4東大・院医・神経生理学，5新潟大・脳研・細胞神経生物学

Ion channels for the resonant property of neurons

Kouichi Hashimoto1, Yoshiko Makidono1, Hisako Nakayama1, Miwako Yamasaki2,
Taisuke Miyazaki2, Kazuto Kobayashi3, Masahiko Watanabe2, Masanobu Kano4,
Kenji Sakimura5
1Dept Neurophysiol, Grad Sch Biomed Health Sci, Hiroshima Univ, Japan, 2Dept Anat, Grad Sch

Med, Hokkaido Univ, Japan, 3Dept Mol Gen, Grad Sch Med, Fukushima Med Univ, Japan, 4Dept
Neurophysiol, Grad Sch Med, Univ Tokyo, Japan, 5Dept Cell Neurobiol, Brain Res Institute, Niigata
Univ, Japan

3PS13B1-4ラット大脳皮質における波状に伝播する内因性信号の観察○大城 朝一，虫明 元
東北大・医・生体システム生理

Optical imaging of the intrinsic signal revealed a wave-like propagation of theinfra-slow oscillation over the rat cortex
Tomokazu Ohshiro, Hajime Mushiake
Dept Physiol, School of Medicine, Tohoku Univ, Sendai, Japan

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Posters Day 2

Iku Kimura1,2, Akiyo Natsubori3, Hiroshi Nishida1, Kenji F Tanaka1

Posters Day 3

The roles of ventral striatal Ca2+ oscillations in goal-directed behavior

Posters Day 1○木村 生1,2，夏堀 晃世3，西田 洋司1，田中 謙二1
1慶應・医・精神，2日本学術振興会特別研究員RPD，3東京都医学総合研究所

第94回⽇本⽣理学会⼤会

3PS13B1-5

ヒト非線形神経振動の操作的研究○北城 圭一1，桂川 需1,2
1理研・脳科学総合研究センター，2東京大・院医

Manipulative approaches to nonlinear neural oscillations in the human brain
Keiichi Kitajo1, Motomu Katsurakawa1,2

1BSI-Toyota Collaboration Center, RIKEN BSI, Wako, Saitama, Japan, 2Univ Tokyo Grad Sch Med,Tokyo, Japan

3PS13B1-6

ドーパミンと強化学習の動的平衡について○森田 賢治東京大・院教育・身体教育

Dopamine and dynamic equilibrium of reinforcement learning
Kenji Morita
Physical and Health Education, Grad Sch Edu, Univ Tokyo, Tokyo, Japan

3PS13B1-7

サル運動野のLFPシータパワーの増加は運動の記憶を反映する○保坂 亮介1，渡辺 秀典2，中島 敏2，虫明 元2
1福岡大・理・応用数学，2東北大学医学部生体システム生理学分野

Increased LFP θ power in primate motor areas reflects memorization of
movement

Ryosuke Hosaka1, Hidenori Watanabe2, Toshi Nakajima2, Hajime Mushiake2
1Dept Applied Math, Fukuoka Univ, 2Dept Physiol, Tohoku Univ Sch Med, Sendai, Japan

Aims & Scope
The network in the nervous system is full of nonlinearity, which gives rise to spatiotemporal pattern beyond the summationof its components, and oscillatory phenomena, which emerge from complex interaction among slow and fast frequency
oscillations. To understand the physiological significance of nonlinearity and oscillations, we need integrative approach
including experimental and theoretical approach at micro- and macro-scopic levels. In this symposium, we will introduce
various approaches to understanding nonlinear and/or oscillatory phenomenon.

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企画シンポジウム 14

C 会場  Planned Symposium 14

Hall C

Lectures

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

日中合同シンポジウム―FAOPS2019に向けて―Computational physiologyの進展

Japan-China Joint Symposium – Towards FAOPS2019 –Progress in computational physiology

Symposia

オーガナイザー・Organizer：
松岡 達（福井大学医学部 統合生理学）
Satoshi Matsuoka (Dept Integ Sys Physiol Fac Med Sci Univ Fukui)

Jianwei Shuai (Dept Physics, Xiamen Univ)

3PS14C1-1

Simulation study of multiscale Ca2+ signals
Jianwei Shuai
Dept Physics, Xiamen Univ, China

3PS14C1-2

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小型中枢神経シナプスにおける伝達物質放出機構の実験とモデルによる解析○川口 真也
同志社大・脳科学研究科

Experimental and model analysis of transmitter release mechanisms at small
presynaptic terminals in the CNS
Shinya Kawaguchi

3PS14C1-3

Posters Day 1

Grad Sch Brain Sci, Doshisha Univ, Kyoto, Japan

心臓ミトコンドリアエネルギー代謝のCa2+調節に関するシミュレーション研究○松岡 達1，竹内 綾子1，齋藤 隆太2，姫野 友紀子31福井大学・医・統合生理，2田辺三菱製薬・先端医薬研究所，3立命館大学・生命科学・生命情報

A simulation study on Ca2+ regulation of energy metabolism in cardiac
mitochondria
Satoshi Matsuoka1, Ayako Takeuchi1, Ryuta Saito2, Yukiko Himeno3

Tanabe Pharma Co. Saitama, Japan, 3Dept Bioinfo, Col Life Sci, Ritsumeikan Univ, Shiga, Japan

3PS14C1-4（AP4）

心臓興奮伝導における生理学的および病態生理学的モデリング研究○津元 国親，倉智 嘉久
大阪大・院医・薬理Physiological and pathophysiological modeling studies of excitation conductionin the heart: prediction from changes in the subcellular Na+ channel distribution
Kunichika Tsumoto, Yoshihisa Kurachi

Posters Day 2

1Dept Integ Sys Physiol Fac Med Sci Univ Fukui, Fukui, Japan, 2Adv Drug Res Lab Mitsubishi

Aims & Scope
Mathematics and computational analysis have been useful tools for integrative and quantitative understanding of logic oflife, physiology. The application has been widely spreading. In this symposium, we will introduce recent progress ofcomputational physiology in China and Japan to further facilitate quantitative research using computation. Profs. Shuai(China), Kawaguchi, Tsumoto and Matsuoka will present simulation-based physiological study on multiscale Ca2+ signals,
transmitter release dynamics at a small CNS presynaptic terminal, electrical conduction in the physiological andpathophysiological heart and cardiac energy metabolism, respectively. We expect this symposium will foster collaborative
works in physiology between China and Japan.

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Posters Day 3

Div Pharma, Grad Sch Med, Osaka Univ, Osaka, Japan

第94回⽇本⽣理学会⼤会

企画シンポジウム 15

D会場  Planned Symposium 15

Hall D

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

視床下部の機能における新たなGABAの役割

Novel roles of GABA in the hypothalamic function
オーガナイザー・Organizer：
矢田 俊彦（自治医科大学医学部 生理学講座 統合生理学部門）
Toshihiko Yada (Div IntegrativePhysiol, Dept Physiol, Jichi Med Univ Sch Med)
渡部 美穂（浜松医科大学医学部医学科 神経生理学講座）
Miho Watanabe (Dept Neurophysiol, Hamamatsu Univ Sch Med)

3PS15D1-1

視床下部におけるGABA神経回路の発達○高山 千利，清水 千草
琉球大・医・分子解剖

Chronological embryonic development of GABAergic networks in the
hypothalamic nuclei involved in feeding behavior
Chitoshi Takayama, Chigusa Shimizu
Dept Mol Anat, Sch Med, Univ Ryukyus, Okinawa, Japan

3PS15D1-2

視床下部背内側核GABA作動性ニューロンの活性化は摂食を亢進する○須山 成朝1，オトゴンウール ゼセムドルジェ 1，小野寺 宏2，矢田 俊彦11自治医大・医・統合生理，2東大・工・光量子センター

Activation of GABAergic neurons in dorsomedial hypothalamus promotes foodintakeShigetomo Suyama1, Zesemdorj Otgonuul1, Hiroshi Onodera2, Toshihiko Yada1

1Div IntegrativePhysiol, Dept Physiol, Jichi Med Univ Sch Med, Tochigi, Japan, 2Photon Sci Cen
Univ Tokyo, Dept Electric Engineering, Univ Tokyo, Tokyo, Japan

3PS15D1-3

生殖機能制御における興奮性GABA作用の役割○渡部 美穂1，鍋倉 淳一2,3，福田 敦夫11浜松医大・神経生理，2生理研・生体恒常，3総研大・生理科学

The role of excitatory action of GABA in the regulation of reproduction
Miho Watanabe1, Junichi Nabekura2,3, Atsuo Fukuda1

1Dept Neurophysiol, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Homeostatic Develop,

Natl Inst Physiol Sci, Okazaki, Japan, 3Dept Physiol Sci, SOKENDAI, Hayama, Japan

3PS15D1-4

視床下部−下垂体系のCRH放出制御における新たなGABAの役割○柿沢 圭亮1，福田 敦夫2
1浜松医大・医・第二内科，2浜松医大・医・神経生理

A novel role of GABA in the release of CRH in the hypothalamic-pituitary
pathway
Keisuke Kakizawa1, Atsuo Fukuda2

1Second Dept Med, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Neurophysiol,

Hamamatsu Univ Sch Med, Hamamatsu, Japan

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3PS15D1-5

マウス視交叉上核におけるGABAの機能○小野 大輔1，本間 研一2，柳川 右千夫3，本間 さと2Roles of GABA in the circadian clock in the mouse suprachiasmatic nucleus
Daisuke Ono1, Ken-ichi Honma2, Yuchio Yanagawa3, Sato Honma2

1Neurosci Res, RIEM, Nagoya Univ, Nagoya, Japan, 2Res & Educ Center Brain Sci, Hokkaido Univ,
Grad Sch Med, Sapporo, Japan, 3Dep of Genet & Behav Neurosci, Gunma Univ Grad Sch Med,
Maebashi, Japan

Lectures

1名大・環研・神経2，2北大・院医・脳科学，3群大・院医・遺伝発達行動

The role of the hypothalamus in regulation of homeostasis is essential for survival and reproduction. In this symposium, we
will focus on the role of GABAergic neurons in the regulation of the hypothalamic function. GABA is typically an inhibitory
neurotransmitter in the mature adult central nervous system. Some neurons in the hypothalamus show the unusual
characteristic of being excited by GABA. GABA has long been implicated as a major player in the regulation of
hypothalamic neurons. However, the precise physiological role of the GABA action on hypothalamic neurons remains
elusive. By using latest technologies such as optogenetics and some transgenic mice, we will discuss recent findings
including (1) the development of GABAergic neuronal network in the hypothalamus; (2) the role of GABAergic neurons in
dorsomedial hypothalamus in feeding regulation; (3) the role of excitatory GABA action in the regulation of corticotropinreleasing hormone neurons and gonadotropin-releasing hormone neurons.

Symposia

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

企画シンポジウム 16

E 会場  Planned Symposium 16

Hall E

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

日本解剖学会連携シンポジウム
機能再生の生物学

Joint Symposium with the Japanese Association of Anatomists
Biology in ‘functional recovery’
オーガナイザー・Organizer：
平井 宏和（群馬大学大学院医学系研究科 脳神経再生医学分野）
Hirokazu Hirai (Dept Neurophysiol & Neural Repair, Gunma Univ Grad Sch Med)
山下 俊英（大阪大学大学院医学系研究科 分子神経科学）
Toshihide Yamashita (Dept Mol Neurosci, Grad Sch Med, Osaka Univ)

3PS16E1-1

損傷神経軸索再生の形態機能生物学○木山 博資名古屋大・院医・機能組織

The morphological and functional biology of nerve regeneration
Hiroshi Kiyama
Dept Functional Anatomy & Neurosci, Nagoya Univ, Grad Sch Med, Nagoya, Japan

3PS16E1-2

正常なマウス膵内分泌組織発生には外分泌組織との共存が必要である○川口 義弥京都大学・iPS細胞研究所

Requirement of exocrine tissue formation for proper endocrine development inmurine pancreas
Yoshiya Kawaguchi
Center for iPS Cell Research and Application, Kyoto Univ Kyoto, Japan

3PS16E1-3

成熟マウス小脳においてプロテインキナーゼCγは運動機能を制御する○平井 宏和，高橋 伸卓，渡邊 将，今野 歩
群馬大・院医・脳神経再生医学

Protein kinase Cγ plays a crucial role in motor function in mature cerebellum
Hirokazu Hirai, Nobutaka Takahashi, Masashi Watanabe, Ayumu Konno
Dept Neurophysiol & Neural Repair, Gunma Univ Grad Sch Med, Gunma, Japan

3PS16E1-4

中枢神経回路の修復のメカニズムと治療法の確立○山下 俊英1
1阪大・院医・分子神経，2阪大・院生命

Development of the therapeutic strategy to regulate reorganization of the
injured central nervous system
Toshihide Yamashita1

1Dept Mol Neurosci, Grad Sch Med, Osaka Univ, Osaka, Japan, 2Grad Sch Front Biosci, Osaka Univ,
Osaka, Japan

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Symposia

Physiological functional recovery of the damaged tissues or organs is pivotal for curing patients. To attain such ‘functional
recovery’ in patients, we need precise and extensive understanding of pathophysiological mechanisms from molecular to invivo aspects. To fulfill that purpose efficiently, we should continue to update our knowledge about the mechanisms and try
to develop novel therapeutic interventions in a multi-disciplinary manner. In this symposium, we would like to offer theaudience an opportunity to update recent knowledge about ‘functional recovery’ based on pathophysiological mechanisms
for various diseases, which speakers with various research expertise have revealed recently. Moreover, through discussions
in this symposium, we expect that the research community as well as the audience would be inspired and stimulated, which
could lead to the future seeds or development of novel therapeutic methods based on the knowledge about ‘functional
recovery’.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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企画シンポジウム 17

B 会場  Planned Symposium 17

Hall B

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

日本神経内分泌学会連携シンポジウム
新しい技術を用いた神経ペプチドニューロン研究の展開

Joint Symposium with the Japan Neuroendocrine Society
Developments of neuropeptide neuron research with new technologies
オーガナイザー・Organizer：
尾仲 達史（自治医科大学生理学講座 神経脳生理学部門）
Tatsushi Onaka (Dept Physiol, Jichi Med Univ)
有馬 寛（名古屋大学大学院医学系研究科 糖尿病・内分泌内科学）
Hiroshi Arima (Dept Endocrinology and Diabetes, Nagoya Univ Grad Sch Med)

3PS17B2-1

マウスiPS細胞を用いたバソプレシンニューロン小胞体ストレスの新たなin vitroモデル○有馬 寛，光本 一樹，萩原 大輔，須賀 英隆
名古屋大学糖尿病・内分泌内科学

A new in vitro model using mouse iPS cells to study endoplasmic reticulum
stress in vasopressin neurons
Hiroshi Arima, Kazuki Mitsumoto, Daisuke Hagiwara, Hidetaka Suga
Dept Endocrinology and Diabetes, Nagoya Univ Grad Sch Med, Nagoya, Japan

3PS17B2-2

グレリンとGLP-1の迷走神経求心路を介する摂食調節機序○迫田 秀之1，ワイズ ティーエム ザベット1，ナズニン ファーハナ1，岡田 只士1，
十枝内 厚次2，中里 雅光1,3
1宮崎大学・医学部・内科学講座，2至学館大学，3AMED-CREST

Interaction between ghrelin and GLP-1 regulates feeding through vagal afferent
systemHideyuki Sakoda1, Zaved Tm Waise1, Farhana Naznin1, Tadashi Okada1,
Koji Toshinai2, Masamitsu Nakazato1,3

1Dept Internal Medicine, Univ, Miyazaki, Miyazaki, Japan, 2Shigakkan University, Obu, Japan,
3AMED-CREST, Tokyo, Japan

3PS17B2-3オレキシンは青斑核に働き情動行動を増強する○櫻井 武1,2，征矢 晋吾1,2，高橋 徹2，前島 隆司21筑波大・医・国際統合睡眠医科学，2金沢大・院医歯薬保健・統合生理Orexin acts on Locus Coeruleus to enhance and sustain emotional behavior
Takeshi Sakurai1,2, Shingo Soya1,2, Toolu Takahashi2, Takashi Maejima2
1WPI-IIIS, Univ Tsukuba, Ibaraki, Japan, 2Dept Mol Neurosci, Kanazawa Univ, Japan

3PS17B2-4

遺伝子改変技術を用いたバゾプレッシンニューロン活動制御の試み○吉村 充弘，丸山 崇，上田 陽一
産業医大・医・第1生理Transgenic approaches to regulate the neuronal activity in vasopressin neuron
Mitsuhiro Yoshimura, Takashi Maruyama, Yoichi Ueta
Dept Physiol, Sch Med, UOEH, Kitakyushu, Japan

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3PS17B2-5

遺伝子改変動物とウィルスベクターを用いたオキシトシンシステム特異的な機能調節○吉田 匡秀，高柳 友紀，犬束 歩，尾仲 達史

Lectures自治医大・医・生理Transgene expression and site-specific ablation in oxytocin system by making
use of transgenic animals and virus vectors
Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Tatsushi Onaka
Dept Physiol, Jichi Med Univ, Tochigi, Japan

Molecular technologies including optogenetics, DREADDs and neurotracing methods with various virus vectors andtransgenic animals have advanced our knowledge in the field of neuropeptide research. Especially, manipulation andrecordings of specific peptidergic pathways enable us to clarify physiological roles of the pathways.
In this symposium, new developments in the field of vasopressin, oxytocin and novel peptides will be introduced. Thissymposium is organized with co-operation of neuroendocrinology society.

Symposia

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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企画シンポジウム 18

C 会場  Planned Symposium 18

Hall C

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

若手の会運営委員会企画シンポジウム
多様な感覚に基づく身体機能の調節 −基礎と臨床の視点から−

Associates of Young Researchers of Physiology
Modulation of body systems based on various sensory inputs– from the perspectives of basic research and clinical application –オーガナイザー・Organizer：
井手 正和（国立障害者リハビリテーションセンター研究所 脳機能系障害研究部 発達障害研究室）
Masakazu Ide (Developmental Disorders Section, Department of Rehabilitation for Brain Functions, ResearchInstitute of National Rehabilitation Center for Persons with Disabilities)
山口 佳小里（国際医療福祉大学成田保健医療学部 作業療法学科）
Kaori Yamaguchi (International University of Health and Welfare, School of Health Sciences at Narita,
Department of Occupational Therapy)

3PS18C2-1

親に運ばれる時に示す子の協調的反応：乳児と仔マウスを用いた比較生物学的解析○吉田 さちね1,2，大西 竜子3,4，恒岡 洋右1，小田 哲子1，黒田 優1，船戸 弘正1，黒田 公美3
1東邦大・医・解剖，2JST・さきがけ，3理研・脳科学総合研究センター，4琉球大・教育学部

An Infant cooperation to maternal carrying: comparative analyses in humans
and mice
Sachine Yoshida1,2, Ryuko Ohnishi3,4, Yousuke Tsuneoka1, Satoko Oda1,
Masaru Kuroda1, Hiromasa Funato1, Kumi O Kuroda3

1Dept Anatomy, Sch Med, Toho Univ, Tokyo, Japan, 2JST, PRESTO, Kawaguchi, Japan, 3RIKNE,
BSI, Wako, Japan, 4Fac Edu, Univ Ryukyus, Okinawa, Japan

3PS18C2-2

知覚／運動系における時間と空間の相互作用○黒田 剛士静岡大学・情報学部

Spatiotemporal interactions in perception and motor action
Tsuyoshi Kuroda
Fac Inform, Shizuoka Univ, Hamamatsu, Japan

3PS18C2-3

統合失調症と自閉性スペクトラム障害における感覚情報処理○中川 与四郎
中部大学作業療法学科

Sensory processing in schizophrenia and autism spectrum disorder
Yoshiro Nakagawa
Dept Occupational therapy, Chubu Univ, Aichi, Japan

3PS18C2-4

自閉症スペクトラム障害における感覚特性と作業療法の実践○松島 佳苗京都大・医学・人間健康科学

Unusual sensory features in autism spectrum disorders and occupational
therapy
Kanae Matsushima
Grad Sch Med, Kyoto Univ, Kyoto, Japan

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我々は、自分の周囲に存在する多様な刺激の 時間 に関わる情報を処理し、外界に対して適応的に身体を調整する。例えば、乳幼児期の哺乳類では、周期的に体性感覚を刺激することで副交感神経の活動は安定し、身体は弛緩する。一方、発達障害や精神疾患において刺激の時間に関わる処理が変容するという報告があり、これは副交感神経による感覚の調節機能にも影響する。このような基礎研究で得られた知見を臨床の現場に応用するような試みは、今後ますます重要性を増していくだろう。
本シンポジウムは、基礎と臨床それぞれの立場の若手研究者を招き、体性感覚や時間感覚、自律神経等について、関連する臨床症状と併せて、学際融合的な討議の場を提供することを目的とする。

Lectures

ねらいと概要※本シンポジウムは全て日本語で開催されます。

Symposia

This symposium will be held in Japanese.

Posters Day 3

Posters Day 2

Posters Day 1

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