NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART,DIRECTLY OR INDIRECTLY, IN ANY JURISDICTION WHERE TO DO SO WOULDCONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION
THIS ANNOUNCEMENT IS NOT AN ANNOUNCEMENT OF A FIRM INTENTION TOMAKE AN OFFER UNDER RULE 2.7 OF THE UK CITY CODE ON TAKEOVERS AND
MERGERS (THE "CODE") AND THERE CAN BE NO CERTAINTY THAT AN OFFER WILL
BE MADE, OR AS TO THE TERMS ON WHICH ANY OFFER WILL BE MADE.
FOR IMMEDIATE RELEASETakeda Statement Regarding Shire plcCambridge, Mass. April 19, 2018 and Osaka, Japan, April 19, 2018 – Takeda Pharmaceutical
Company Limited (“Takeda”) notes recent press speculation regarding Shire plc (“Shire”) andconfirms that on April 12 it made a revised proposal to the Board of Shire to acquire the entire
issued and to be issued share capital of Shire for a price equivalent to £46.50 per share, comprisedof £17.75 in cash (to be paid in US$) and £28.75 of new Takeda shares.
Takeda was subsequently notified that the Board of Shire had rejected its proposal. Discussions
between the parties regarding a potential offer are ongoing.
Takeda and its Board reiterate that it will remain disciplined with respect to the terms of any suchoffer. As previously stated, Takeda intends to maintain its well-established dividend policy andinvestment grade credit rating.
Building on Takeda’s existing momentum, the acquisition of Shire would accelerate its
transformation and result in a global, value-based, R&D-driven biopharmaceutical leader
headquartered in Japan, with a balanced geographic footprint, a robust, modality-diverse pipeline
and enhanced financial strength.
Irrespective of the outcome of discussions between the two parties, Takeda remains wellpositioned to continue its transformation, delivering portfolio growth while strengthening its
pipeline and boosting profitability.

Other matters
The making of any firm offer by Takeda would be subject to the following matters:•satisfactory completion of a customary due diligence review by Takeda;•

unanimous and unconditional recommendation by the Board of Shire in respect ofTakeda’s proposal;•the directors of Shire providing irrevocable undertakings to vote in favour of, or accept,
the transaction in respect of their Shire shares on terms satisfactory to Takeda; and//1•final approval by the Board of Takeda.

Takeda reserves the right to waive in whole or in part any of the pre-conditions to making an offer
set out in this announcement.
Takeda’s proposal does not constitute an offer or impose any obligation on Takeda to make anoffer, nor does it evidence a firm intention to make an offer within the meaning of the Code. Therecan be no certainty that a formal offer will be made. A further statement will be made as
appropriate.
Takeda reserves the following rights:•to introduce other forms of consideration and/or to vary the mix of consideration;•to make an offer for Shire at any time on less favourable terms:•owith the agreement or recommendation of the Board of Shire;

oif a third party announces a firm intention to make an offer for Shire which, at thedate Takeda announces a firm intention to make an offer for Shire, is valued at alower price than contemplated by the terms of this proposal; orofollowing the announcement by Shire of a whitewash transaction pursuant to theCode; andin the event that any dividend and/or other form of capital return or distribution isannounced, declared, made or paid by Shire, other than the 2017 second interim dividendof £0.2146 per ordinary share and $0.8937 per ADS payable on 24 April 2018, to reduce
its offer by the amount of such dividend and/or other form of capital return or distribution.

In accordance with Rule 2.6(a) of the Code, Takeda must, by no later than 5.00 p.m. (Londontime) on 25 April 2018, either announce a firm intention to make an offer, subject to conditions orpre-conditions if relevant, for Shire in accordance with Rule 2.7 of the Code or announce that it
does not intend to make an offer for Shire, in which case the announcement will be treated as astatement to which Rule 2.8 of the Code applies. This deadline will only be extended with theconsent of the UK Panel on Takeovers and Mergers (the “Panel”) in accordance with Rule 2.6(c)of the Code.
In accordance with Rule 26.1 of the Code, a copy of this announcement will be published on theTakeda website (https://www.takeda.com/newsroom/) by no later than 12 noon (London time) on
April 20, 2018. The content of the websites referred to in this announcement is not incorporated
into and does not form part of this announcement.

About Takeda
Takeda is a global, research and development-driven pharmaceutical company committed tobringing better health and a brighter future to patients by translating science into life-changing
medicines. Takeda focuses its R&D efforts on oncology, gastroenterology and neuroscience
therapeutic areas plus vaccines. Takeda conducts R&D both internally and with partners to stay atthe leading edge of innovation. Innovative products, especially in oncology and gastroenterology,
as well as Takeda’s presence in Emerging Markets, are currently fuelling the growth of Takeda.

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Approximately 30,000 Takeda employees are committed to improving quality of life for patients,
working with Takeda’s partners in health care in more than 70 countries.
For more information, visit https://www.takeda.com/newsroom/.
Contacts:Takeda
Elissa Johnsen
elissa.johnsen@takeda.com+1 224 554 3185Takeda
Tsuyoshi Tada
tsuyoshi.tada@takeda.com+1 617 551 2933

Evercore Partners International LLP(joint financial advisor to Takeda)(US) Will Hiltz
John Honts+1 212 857 3100
(UK) Julian Oakley+44 207 653 6000

J.P. Morgan(joint financial advisor to Takeda)
Michele Colocci
Dwayne Lysaght
James Mitford+44 207 742 4000

Nomura (joint financial advisor to Takeda)
Akira Kiyota
Paolo Cicchine
Andrew McNaught
Oliver Tucker+44 207 102 1000

Finsbury(communications support to Takeda)(UK) James Murgatroyd / Rollo Head / Anjali
Unnikrishnan+44 207 251 3801
(US) Kal Goldberg / Chris Ryall+1 646 805 2000

IMPORTANT NOTICEThis announcement is not intended to, and does not, constitute, represent or form part of any offer,invitation or solicitation of an offer to purchase, otherwise acquire, subscribe for, sell or otherwise
dispose of, any securities whether pursuant to this announcement or otherwise.
The distribution of this announcement in jurisdictions outside the United Kingdom or Japan may
be restricted by law or regulation and therefore any person who comes into possession of thisannouncement should inform themselves about, and comply with, such restrictions. Any failure tocomply with such restrictions may constitute a violation of the securities laws or regulations of any
such relevant jurisdiction.
Evercore Partners International LLP ("Evercore"), which is authorised and regulated in the United
Kingdom by the Financial Conduct Authority, is acting as financial adviser for Takeda and no one
else in connection with the matters set out in this announcement and will not regard any otherperson as its client in relation to the matters in this announcement and will not be responsible toanyone other than Takeda for providing the protections afforded to clients of Evercore, nor forproviding advice in relation to any matter referred to herein.
JPMorgan Securities Japan Co., Ltd., together with its affiliate J.P. Morgan Securities plc (whichconducts its UK investment banking business as J.P. Morgan Cazenove and which is authorised in
the United Kingdom by the Prudential Regulation Authority and regulated in the United Kingdom//3

by the Prudential Regulation Authority and the Financial Conduct Authority) ("J.P. Morgan"), isacting as financial adviser for Takeda and no one else in connection with the matters set out in thisannouncement and will not regard any other person as its client in relation to the matters set out inthis announcement and will not be responsible to anyone other than Takeda for providing theprotections afforded to clients of J.P. Morgan or its affiliates, nor for providing advice in relation
to any matter referred to herein.
Nomura International plc ("Nomura"), which is authorised by the Prudential Regulation Authority
and regulated by the Prudential Regulation Authority and the Financial Conduct Authority in theUnited Kingdom, is acting as financial adviser for Takeda and no one else in connection with thematters set out in this announcement and Nomura International plc, its affiliates and its respective
officers, employees, agents, representatives and/or associates will not regard any other person as
their client, nor will they be responsible to anyone other than Takeda for providing the protections
afforded to clients of Nomura International plc nor for giving advice in relation to any matter orarrangement referred to in this announcement.
Forward-Looking Statements
This announcement contains forward-looking statements regarding Takeda’s future business,future position and results of operations, including estimates, forecasts, targets and plans. These
forward-looking statements may be identified by the use of forward-looking words such as “aim,”“anticipate,” “assume,” “believe,” “continue,” “endeavor ,” “estimate,” “expect,” “forecast,”“initiative,” “intend,” “may,” “outlook,” “plan,” “potential,” “probability,” “pro forma,” “project,”“risk,” “seek” “should,” “strive,” “target,” “will,” or similar words or expressions of the negative
thereof, or by discussions of strategy, plans or intentions.
Any forward-looking statements in this announcement are based on the current assumptions andbeliefs of Takeda in light of the information currently available to it. Such forward-looking
statements do not represent any guarantee by Takeda or its management of future performance andinvolve known and unknown risks, uncertainties and other factors, including but not limited to: theeconomic circumstances surrounding Takeda’s business, including general economic conditions inJapan, the United States and worldwide; competitive pressures and developments; applicable laws
and regulations; the success of or failure of product development programs; decisions of regulatory
authorities and the timing there of; changes in exchange rates; claims or concerns regarding thesafety or efficacy of marketed products or products candidates; and post-merger integration withacquired companies, any of which may cause Takeda’s actual results, performance, achievements
or financial position to be materially different from any future results, performance, achievements
or financial position expressed or implied by such forward-looking statements. Neither to Takeda
nor its management gives any insurances that the expectations expressed in these forward-looking
statements will turn out to be correct, and actual results, performance or achievements could
materially differ from expectations.
Any forward-looking statements herein speak only as of the date of this announcement , andTakeda and its management undertake no obligation to update or revise any forward-looking
statements or other information contained in this presentation, whether as a result of newinformation, future events or otherwise.
Disclosure requirements of the Code//4

Under Rule 8.3(a) of the Code, any person who is interested in 1% or more of any class of relevant
securities of an offeree company or of any securities exchange offeror (being any offeror otherthan an offeror in respect of which it has been announced that its offer is, or is likely to be, solelyin cash) must make an Opening Position Disclosure following the commencement of the offer
period and, if later, following the announcement in which any securities exchange offeror is firstidentified. An Opening Position Disclosure must contain details of the person’s interests and shortpositions in, and rights to subscribe for, any relevant securities of each of (i) the offeree companyand (ii) any securities exchange offeror(s). An Opening Position Disclosure by a person to whom
Rule 8.3(a) applies must be made by no later than 3.30 pm (London time) on the 10th business day
following the commencement of the offer period and, if appropriate, by no later than 3.30 pm(London time) on the 10th business day following the announcement in which any securities
exchange offeror is first identified. Relevant persons who deal in the relevant securities of theofferee company or of a securities exchange offeror prior to the deadline for making an Opening
Position Disclosure must instead make a Dealing Disclosure.
Under Rule 8.3(b) of the Code, any person who is, or becomes, interested in 1% or more of any
class of relevant securities of the offeree company or of any securities exchange offeror must makea Dealing Disclosure if the person deals in any relevant securities of the offeree company or of anysecurities exchange offeror. A Dealing Disclosure must contain details of the dealing concernedand of the person’s interests and short positions in, and rights to subscribe for, any relevant
securities of each of (i) the offeree company and (ii) any securities exchange offeror(s), save to theextent that these details have previously been disclosed under Rule 8. A Dealing Disclosure by aperson to whom Rule 8.3(b) applies must be made by no later than 3.30 pm (London time) on thebusiness day following the date of the relevant dealing.
If two or more persons act together pursuant to an agreement or understanding, whether formal orinformal, to acquire or control an interest in relevant securities of an offeree company or asecurities exchange offeror, they will be deemed to be a single person for the purpose of Rule 8.3.
Opening Position Disclosures must also be made by the offeree company and by any offeror andDealing Disclosures must also be made by the offeree company, by any offeror and by any persons
acting in concert with any of them (see Rules 8.1, 8.2 and 8.4).
Details of the offeree and offeror companies in respect of whose relevant securities Opening
Position Disclosures and Dealing Disclosures must be made can be found in the Disclosure Tableon the Panel’s website at www.thetakeoverpanel.org.uk, including details of the number ofrelevant securities in issue, when the offer period commenced and when any offeror was firstidentified. You should contact the Panel’s Market Surveillance Unit on +44 (0)20 7638 0129 if
you are in any doubt as to whether you are required to make an Opening Position Disclosure or a
Dealing Disclosure.

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