第94回⽇本⽣理学会⼤会

公募シンポジウム 1

A 会場  Symposium 1

Hall A

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50【味の素株式会社協賛】
情動行動における口腔・腸̶脳連関の重要性【Supported by Ajinomoto Co., Inc.】

Oral/gut-brain interaction in emotional behavior
オーガナイザー・Organizer：
飛田 秀樹（名古屋市立大学 医学研究科 脳神経生理学）
Hideki Hida (Dept of Neurophysiol & Brain Sci, Nagoya City Univ Grad Sch Med Sci)
二ノ宮 裕三（九州大学 味覚・嗅覚センサ研究開発センター）
Yuzo Ninomiya (Div Sens Physiol, R&D Ctr Taste Odor Sens, Kyushu Univ)

1S01A1-1

口腔腸脳機能分子連関: グルコース輸送体を介する甘味受容伝達経路○二ノ宮 裕三1,2，中野 啓子1,3，大栗 弾宏3，岩田 周介2,3，高井 信吾3，吉田 竜介3，
重村 憲徳3，マルゴルスキー ロバート2,3
1九大・味覚嗅覚研究センター，2米国モネル化学感覚研，3九大・院歯・口腔機能

Oral-gut-brain linkage with molecules involved in glucose-sensing sweet taste
pathway

Yuzo Ninomiya1,2, Keiko Nakano1,3, Tadahiro Ohkuri3, Shusuke Iwata2,3,
Shingo Takai3, Ryusuke Yoshida3, Noriatsu Shigemura3, Robert Margolskee2,3

1Div Sens Physiol, R&D Ctr Taste Odor Sens, Kyushu Univ, Fukuoka, Japan, 2Monell Chem Sens
Ctr, Philadelphia, USA, 3Sect Oral Neurosci, Grad Sch Dent Sci, Kyushu Univ, Fukuoka, Japan

1S01A1-2

かつおだし摂取がマウスの情動行動に及ぼす効果とその神経メカニズム○西丸 広史1，Jargalsaikhan Undarmaa1，松本 惇平1，高村 雄策1，中村 友也1，
掘 悦郎1，近藤 高史 2，小野 武年1，西条 寿夫1
1富山大・院医・システム情動科学，2（株）味の素・イノベーション研究所

Effects of dried-bonito broth (dashi) ingestion on emotional behaviors and their
possible mechanism in young mice

Hiroshi Nishimaru1, Undarmaa Jargalsaikhan1, Jumpei Matsumoto1,
Yusaku Takamura1, Tomoya Nakamura1, Etsuro Hori1, Takashi Kondoh2,
Taketoshi Ono1, Hisao Nishijo1

1Syst Emotional Sci, Univ Toyama, Toyama, Japan, 2Inst Innovation, Ajinomoto Co, Inc, Kawasaki,
Japan

1S01A1-3

注意欠陥多動性モデルラットでの発育期のグルタミン酸ナトリウムによる攻撃性の減少
は胃迷走神経を介する○飛田 秀樹，横山 善弘，丸本 良介，三角 吉代，西垣 瑠里子，永井 遥，上田 佳朋，
石田 章真，鄭 且均
名古屋市大・院医・脳神経生理

Decreased aggression by monosodium glutamate during the period ofdevelopment is mediated by vagus nerve in an attention-deficit hyperactivity
disorder model rat
Hideki Hida, Yoshihiro Yokoyama, Ryosuke Marumoto, Sachiyo Misumi,
Ruriko Nishigaki, Haruka Nagai, Yoshitomo Ueda, Akimasa Ishida, Cha-gyun Jung
Dept Neurophysiol & Brain Sci, Nagoya City Univ Grad Sch Med Sci, Nagoya, Japan

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1S01A1-4

うつ病や関連疾患における腸内細菌の役割○功刀 浩

Lectures

国立精・神医研セ・疾病三部

Role of gut microbiota in depression and related disorders
Hiroshi Kunugi
Dept Mental Disorder Research, NCNP, Tokyo, JapanThe gut and the brain are closely connected. Recent neurobiological studies in this gut-brain crosstalk have revealed
bidirectional communication system by neural communication (vagal, sympathetic) and systemic communication (HPA axis,
neurotransmitters, bacterial metabolites, cytokines). This gut-brain crosstalk is likely to have multiple effects on affection,
motivation, and higher cognitive functions. Disturbances of this system have been implicated in a wide range of disorders,
including anxiety, depression and neurodevelopmental disease such as attention-deficit hyperactivity disorder (ADHD).
In this symposium, we focused on the effect of taste substances on emotional behavior from the aspect of “oral/gut-brain
interaction”. The importance of oral/gut-brain interactions will be shown by at least four speakers. Dr. Ninomiya will present
new data showing sugar sensing pathway in the gut is also found in taste cells in the oral cavity. Dr. Nishimaru will present
the effect of “umami” and “dashi” on the emotional behavior focusing on the amygdala and the prefrontal cortex. Dr. Hida
will show the effect of an umami substance on aggressive behavior in an ADHD model rat, which is mediated by vagus
nerve. Dr. Kunugi will show the importance of the gut-brain interaction in anxiety and depression.

Symposia

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

公募シンポジウム 2

B 会場  Symposium 2

Hall B

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

シナプス機能研究の新展開

New developments in synapse research
オーガナイザー・Organizer：
喜多村 和郎（山梨大学大学院 総合研究部）
Kazuo Kitamura (Graduate School Department of Interdisciplinary Research, University of Yamanashi)
篠田 陽（東京薬科大学 薬学部）
Yo Shinoda (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

1S02B1-1（AP2）哺乳類脳で内在性タンパク質の局在や動態を可視化する新たなストラテジー○三國 貴康1，西山 潤1，スン イェ 1,2，釜澤 尚美1，安田 涼平1
1マックスプランクフロリダ研究所，2フロリダアトランティック大A new strategy for imaging protein localization and dynamics in the mammalian
brain
Takayasu Mikuni1, Jun Nishiyama1, Ye Sun1,2, Naomi Kamasawa1,
Ryohei Yasuda1

1Max Planck Florida Inst Neurosci, Jupiter, USA, 2Florida Atlantic Univ, Jupiter, USA

1S02B1-2

シナプスタンパク質のリン酸化の化学量論およびシナプス構造の新しいモデル○細川 智永理研・脳科学

Stoichiometry of synaptic protein phosphorylation and a novel model forsynaptic structure
Tomohisa Hosokawa
RIKEN, BSI, Saitama, Japan

1S02B1-3

C1qファミリー分子によるシナプス形成制御機構○松田 恵子，柚崎 通介
慶應大・医学部・生理学

Synapse organization and modulation via C1q family proteins and their
receptors
Keiko Matsuda, Michisuke Yuzaki
Dept Physiol, Keio Univ Sch Med, Tokyo, Japan

1S02B1-4哺乳類中枢シナプス前終末の生理学的研究○坂場 武史同志社大学大学院脳科学研究科

Presynaptic physiology in the mammalian CNS
Takeshi Sakaba
Grad Sch Brain Science, Doshisha Univ, Kyoto, Japan

1S02B1-5

シナプス可塑性：基礎から臨床へ○高橋 琢哉横浜市立大学・医学部・生理学

Synaptic plasticity: from bench to bedside
Takuya Takahashi
Dept Physiol, Sch Med, Yokohama City Univ, Kanazawaku, Japan

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Symposia

Synapses are critical determinants for a wide range of neuronal functions including neural information processing, plasticity,
circuit formation and behavior. The advent of novel technologies such as imaging, optogenetics and genome editing has
shed light on important insights into the synaptic functions. Furthermore, discoveries of novel molecules and uniqueconcept have been extending our understanding of organization and functionality of synaptic circuits. In this symposium,
leading synapse researchers “synaptologists” will introduce their cutting-edge researches on pre- and post-synaptic
functions and their underlying mechanisms, and will discuss the future outlook of synapse research.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

公募シンポジウム 3

D 会場  Symposium 3

Hall D

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

味覚の分子生理学の最前線

Frontiers in molecular physiology of taste
オーガナイザー・Organizer：
樽野 陽幸（京都府立医科大学大学院医学研究科 細胞生理学）
Akiyuki Taruno (Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural
University of Medicine)
吉田 竜介（九州大学大学院歯学研究院 口腔機能解析学分野）
Ryusuke Yoshida (Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University)

1S03D1-1

味覚受容体リガンド結合領域への味物質結合と構造変化○山下 敦子
岡山大・医歯薬

Taste-substance binding and conformational change of the ligand-binding
domains of taste receptor
Atsuko Yamashita
Grad Sch Med, Dent & Pharm Sci, Okayama Univ, Okayama, Japan

1S03D1-2

霊長類味覚受容体の分子生理学○今井 啓雄京都大・霊長研

Molecular physiology of primate taste receptors
Hiroo Imai
Primate Research Inst, Kyoto Univ, Inuyama, Japan

1S03D1-3脂肪酸の感覚を伝えるためのGタンパク共役型受容体とマウス鼓索神経における神経
コーディング○安松 啓子，二ノ宮 裕三
九大・味覚・嗅覚センサR&DCtr

G-protein coupled receptors and neural coding for sensing fatty acids in mouse
chorda tympani nerve
Keiko Yasumatsu, Yuzo Ninomiya
Div Sensory Physiology, R&D Center for Taste and Odor Sensing, Kyushu Univ

1S03D1-4

口腔感覚修飾物質γ-glutamyl-valyl-glycineは三叉神経応答を増強する○丸山 豊1
1味の素・イノベーション研，2カリフォルニア大学デービス校

A flavor modifier, γ-glutamyl-valyl-glycine, has enhancement effect on the
response of trigeminal neuronal cells
Yutaka Maruyama1

1Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Japan, 2Dept Neurobiol, Physiol, Behavior,

Univ California, Davis, USA

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1S03D1-5

味幹細胞培養系の確立○岩槻 健

Lectures

東農大・応生・食安健

Generation of taste stem cell culture system
Ken Iwatsuki
Dept Nutri Sci Food Safety, Tokyo Univ Agri, Tokyo, Japan

Cloning of taste receptors and other taste-related genes has greatly facilitated our understanding of taste physiology atmolecular levels. However, information on dynamic aspects of these taste-related molecules is still lacking. Also, many taste
phenomena in detection and transmission of taste have yet to be delineated at molecular levels. Recently, by virtue ofapplication of molecular structural analyses and genomic techniques, remarkable progress has been made in this field.
In this symposium, we would like to introduce recent researches toward molecular mechanisms in the peripheral taste
system (i.e. taste buds). (1) The world’s first observation of conformational change of taste receptors (Yamashita) (2) SGLT1mediated taste receptor-independent mechanism for sensing sugars (Yasumatsu) (3) Discovery of oral sense modifiers(kokumi substances) and the receptor (Maruyama) (4) Enhancement of neuronal response by a flavor modifier (Maruyama)(5) Development of taste bud organoid culture system as a newest tool in taste research (Iwatsuki).

Symposia

Aims & Scope

The roster includes both male and female scientists who are junior, mid-track and senior, and who belong to university andcompany.

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

公募シンポジウム 4

E 会場  Symposium 4

Hall E

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

ナノ技術による生理学・医学の新展開

Promotion of physiology and medicine with nanotechnologies
オーガナイザー・Organizer：
八尾 寛（東北大学大学院 生命科学研究科）
Hiromu Yawo (Dept Dev Biol Neurosci, Tohoku Univ Grad Sch Life Sci)

Angelo Homayoun ALL (Dept Orthopedic Surgery, Natl Univ Singapore)

1S04E1-1

Controlling photon upconversion in lanthanide-doped nanocrystals
Xiaogang Liu1,2

1Dept Chem, Natl Univ Singapore, Singapore, 2Inst Materials Research Engineering, A*STAR,

Singapore

1S04E1-2

Selective stimulation of deeper CNS neuropathways by novel near infraredupconversion nanoparticles–channelrhodopsin transfection approach
Angelo Homayoun All
Dept Orthopedic Surgery, Natl Univ Singapore, Singapore

1S04E1-3

近赤外光駆動ナノロボットによる細胞機能の遠隔制御○都 英次郎
産総研・ナノ材料

Remote control of cellular functions by NIR light-powered nanorobots
Eijiro Miyako
AIST, NMRI, Tsukuba, Japan

1S04E1-4

有機−ナノハイブリッド材料設計に基づく生体解析技術の開発○水上 進
東北大・多元研

Development of bioanalytical technologies based on rational design of organicnano hybrid materials
Shin Mizukami
IMRAM, Tohoku Univ, Sendai, Japan

1S04E1-5

アップコンバージョン・ナノ粒子を用いた近赤外光によるニューロンネットワークの光操作○八尾 寛1,2，細島 頌子3，湯浅 英哉4，山下 貴之5，山中 章弘5，石塚 徹11東北大・院生命・脳機能解析，2東北大・院医・脳コア，3名工大・院工・生命応用化学，4東工大・生命理工，5名大・環境医学・神経2

Upconversion-rhodopsin hybrid system for near-infrared manipulation ofneural network

Hiromu Yawo1,2, Shoko Hososhima3, Hideya Yuasa4, Takayuki Yamashita5,
Akihiro Yamanaka5, Toru Ishizuka1

1Dept Dev Biol Neurosci, Tohoku Univ Grad Sch Life Sci, Sendai, Japan, 2Ctr Neurosci, Tohoku Univ

Grad Sch Med, Sendai, Japan, 3Dept Front Mater, Nagoya Inst Technol, Nagoya, Japan, 4Dept Life
Sci, Grad Sch Biosci Biotech, Tokyo Inst Technol, Yokohama, Japan, 5Dept Neurosci II, Res Inst
Environ Med, Nagoya Univ, Nagoya, Japan

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Symposia

One of the most promising tools for future applications in science and medicine is the use of nanotechnologies. The
nanoparticles which consist of various materials have unique properties, such as fluorescence, luminescence andthermogenesis, and have a potential to manipulate the molecular and cellular functions. For example, the upconversion
nanoparticles (UCNs), which absorb near-infrared light and emit visible light, have been applied as donors to activate
channelrhodopsins. As a result, the activity of a channelrhodopsin-expressing neuron was manipulated by near-infrared
light when the UCNs lie nearby. The UCNs would increase our understanding of the mechanisms of brain disease andenable us to develop novel therapies for them with at least two advantages. First, the targeted neurons would be able to be
irradiated remotely with minimal damage to the brain as near-infrared light penetrates deep in the biological tissues.
Second, the effects of irradiation would be localized to regions close to the UCNs. In this symposium, we will discuss how
the nanoparticles with various properties would contribute the future physiology and medicine.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

公募シンポジウム 5

F 会場  Symposium 5

Hall F

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

イオンチャネルのCa2+による調節機構の多様性とその病態生理機能

Diversification of Ca2+ tuning mechanism of ion channels and its pathophysiological role
オーガナイザー・Organizer：
森 誠之（京都大学工学研究科 合成・生物専攻）
Masayuki X. Mori (Dept Synth & Chem, Grad Sch Eng, Kyoto Univ)
亀山 正樹（鹿児島大学大学院医歯学総合研究科 神経筋生理学）
Masaki Kameyama (Dept Physiol, Grad Sch Med & Dent Sci, Kagoshima Univ)

1S05F1-1

Ca2+によるアクティブゾーンCa2+チャネルの微調節○持田 澄子
東京医大・医・細胞生理

Constitutive and Ca2+-dependent fine-tuning of the active zone Ca2+ channels※ご発表順変更
Sumiko Mochida
Changing
presentation order Dept Physiol, Tokyo Medical Univ, Tokyo, Japan
1S05F1-2

新規致死性不整脈「カルモジュリン病」の遺伝子基盤と病態生理、およびゲノム編集を用いた患者iPS心筋細胞の機能回復○蒔田 直昌1，山本 雄太2，牧山 武2，吉田 善紀3，堀江 稔4
1長崎大・分子生理，2京都大・循内，3京都大・iPS研究所，4滋賀医大・呼吸循内

Genetic and physiological basis of a lethal arrhythmia entity“calmodulinopathy”, and functional rescue by genome-editing in a patientderived iPS cell model

Naomasa Makita1, Yuta Yamamoto2, Takeru Makiyama2, Yoshinori Yoshida3,
Minoru Horie4

1Dept Mol Physiol, Nagasaki Univ Grad Sch Biol Sci, Nagasaki, Japan, 2Dept Cardiovasc Med, Kyoto

Univ Grad Sch Med, Kyoto, Japan, 3Kyoto Univ iPS Cell Research Application, Kyoto Japan, 4Dept
Resp Cardiovasc Med, Shiga Univ Med Sci, Otsu, Japan

1S05F1-3

カルモジュリンによるCav1.2チャネルの制御機構○蓑部 悦子1，森 誠之2，亀山 正樹11鹿児島大・医歯総研・神経筋生理，2京都大・工・合成生物化学

Regulation of Cav1.2 channels by calmodulin: A study on genetically mutatedchannels
Etsuko Minobe1, Masayuki X Mori2, Masaki Kameyama1

1Dept Physiol, Grad Sch Med & Dent Sci, Kagoshima Univ, Kagoshima Japan, 2Dept Synth & Chem,
Grad Sch Eng, Kyoto Univ, Kyoto, Japan

1S05F1-4

温めた心筋収縮系に備わったCa2+ 独立な収縮振動が明らかにする心拍におけるCa2+ 変動の役割○新谷 正嶺1,2，鷲尾 巧3，樋口 秀男11東京大学・理学部・物理学科，2日本学術振興会

特別研究員PD，3東京大学・人間環境学専攻

Ca2+ independent contractive oscillations intrinsic to heating cardiomyocytes
reveal an role of Ca2+ variations in heartbeat
Seine A Shintani1,2, Takumi Washio3, Hideo Higuchi1

1Dept Phys, Grad Sch Sci, Univ Tokyo, Tokyo, Japan, 2JSPS Research Fellow, 3Dept Human andEngineered Environmental Studies, Univ Tokyo, Tokyo, Japan

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1S05F1-5細胞増殖におけるTRPC3の役割○梅村 将就1，小田 香代子1，石川 義弘1,2

The function of Transient Receptor Potential Canonical 3 (TRPC3) channel in cellproliferation
Masanari Umemura1, Kayoko Oda1, Yoshihiro Ishikawa1,2

1Cardiovascular Research Inst, Yokohama City Univ Grad Sch Med, 2Dept Enviromental ImmunoDermato, Yokohama City Univ Grad Sch Med

Ca2+ buffering alters lobe specificity of CaM regulations on TRPC6 channels

Onur Kerem Polat1, Masatoshi Uno2, Terukazu Maruyama1, Masayuki X Mori1,
Kayo Imamura3, Mariko Ariyoshi2, Masahiro Shirakawa2, Hidehito Tochio3,
Yasuo Mori11Dept Syn and Biol Chem, Grad Sch Eng, Kyoto Univ, Japan, 2Dept Mol Eng, Grad Sch Eng, Kyoto

Univ, Japan, 3Dept Biophys, Grad Sch Sci, Kyoto Univ, Japan

1S05F1-7

Bidirectional Ca2+ regulations of Ca2+ permeable channels

Symposia

1S05F1-6

Lectures1横浜市立大学医学部循環制御医学，2横浜市立大学大学院 環境免疫病態皮膚科学

Xiaodong Liu, Yuxia Liu, Yaxiong Yang
Tsinghua University, China

Posters Day 3

Posters Day 2

Functional Ca2+ tuning of ion channels contributes to critical roles in heart, brain and the other systems. Previous studies
revealed remarkable diversification and complex tuning mechanisms of ion channels by Ca2+ which are mediated throughcalciumsensing proteins and/or classical or non-classical Ca2+ sensing amino acid residues. Furthermore, dysregulations of
the Ca2+ tuning are linked with genetic diseases such as autism, cardiac arrhythmia, and kidney diseases which are causedby disordersof the electrical / Ca2+ signaling activities. Thus, the tuning mechanisms of ion channels will have substantial
impact for therapeutic targets in future. Our aim in this symposium is to update the knowledge of ion channel tuning
mechanisms by Ca2+and to understand how and when Ca2+ tuning of ion channels occurs and contributes topathophysiological functions.

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Posters Day 1

Aims & Scope99第94回⽇本⽣理学会⼤会

公募シンポジウム 6

G 会場  Symposium 6

Hall G

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

生理学から薬理学への医学教育キャリーオーバー：何をどこまで教えればよいのか？

Carry-over of medical education from physiology to pharmacology:
what and to where should we teach?
オーガナイザー・Organizer：
安西 尚彦（千葉大学大学院医学研究院 薬理学）
Naohiko Anzai (Dept Pharmacol, Chiba Univ Grad Sch Med)
鯉淵 典之（群馬大学大学院医学系研究科 応用生理学分野）
Noriyuki Koibuchi (Department of Integrative Physiology Gunma University Graduate School of Medicine)

1S06G1-1

イントロダクション○安西 尚彦千葉大・院医・薬理Introduction
Naohiko Anzai
Dept Pharmacol, Chiba Univ Grad Sch Med, Chiba, Japan

1S06G1-2

薬理学講義、どこまで教えればよいのか？：基礎薬理学者の立場から○齊藤 源顕高知大・医・薬理Pharmacological lectures in Kochi Medical School
Motoaki Saito
Dept Pharmacol, Kochi Univ Kochi Med Sch, Japan

1S06G1-3

循環生理学教育における個人的悩み：医学生理学でどこまで教えると良いのか？
○平野 勝也香川大・医・自律機能生理

My personal concerns regarding to what extent I should teach in medical
physiology, with a focus on cardiovascular physiology
Katsuya Hirano
Dept Cardiovasc Physiol, Fac Med Kagawa Univ, Miki-cho, Kita-gun, Kagawa, Japan

1S06G1-4

基礎医学における生理学教育をどのように薬理学教育に繋げて行くのか○中島 昭
藤田保健衛生大・医・生理化学

Linking physiology education to pharmacology education in basic medical
sciences
Akira Nakashima
Dept Physiol Chem, Fujita Health Univ Sch Med, Aichi, Japan

ねらいと概要米国ECFMGが2023年以降、医学教育の国際的認証を受けている医科大学・医学部の卒業生以外には受験資格を認めないと宣言したことが引き金になり、我が国でも医学教育が国際認証を受けるべきとの気運が全国的に高まっているのは周知の事実である。特に米国では少なくとも80週行われている診療型参加実習の時間確保のため、評価ポイントとして重視される統合カリキュラムや少人数Active Learningの導入により、従来型の講義時間が大幅に削減されてきているのが共通の実情ではないかと思われる。そこでここ数年のうちに生理学ないし薬理学の教授に就任し、直後にコマ数削減という事態に直面した経験を持つ先生方を演者として、
項目的にオーバーラップの多い生理学と薬理学の棲み分けをどうすれば良いのか？、現在求められているキャリーオーバーについてそれぞれの視点から提案をすることで相互の理解を深めることを目的とする。
※本シンポジウムは全て日本語で開催されます。

This symposium will be held in Japanese.

100The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 7

H 会場  Symposium 7

Hall H

Lectures

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50【新学術「先端バイオイメージング支援プラットフォーム」共催】
非侵襲ヒト生体光イメージング：解剖・生理学研究の革新的ツール【Co-sponsored by the MEXT "Advanced bioimaging support"】

オーガナイザー・Organizer：
星 詳子（浜松医科大学光先端医学教育研究センター 生体医用光学研究室）
Yoko Hoshi (Dept Biomedical Optics, Hamamatsu Univ Sch Med)

1S07H1-1

時間領域拡散蛍光トモグラフィによる生体組織深部蛍光ターゲットの定量イメージング

Symposia

Non-invasive human optical imaging:innovative tools for investigating anatomy and physiology○西村 吾朗北海道大学・電子研

RIES, Hokkaido Univ, Japan

1S07H1-2

マイクロコンベックスプローブを用いた非侵襲光音響イメージング○大川 晋平1，精 きぐな2，新地 祐介3，中村 亜希子1，平沢 壮1，津田 均4，和田 隆亜5，
堀口 明男3，櫛引 俊宏1，笹 秀典2，古谷 健一2，淺野 友彦 3，石原 美弥1
1 防衛医大・医用工学，2 防衛医大・産科婦人科，3 防衛医大・泌尿器科，4 防衛医大・病態病理科，5 富士

フィルム・R&D統括本部

Noninvasive photoacoustic imaging using microconvex probe

Shinpei Okawa1, Kiguna Sei2, Masayuki Shinchi3, Akiko Nakamura1,
Takeshi Hirasawa1, Hitoshi Tsuda4, Takatsugu Wada5, Akio Horiguchi3,
Toshihiro Kushibiki1, Hidenori Sasa2, Kenichi Furuya2, Tomohiko Asano3,
Miya Ishihara1
1Dept Med Eng, Natl Def Med Col, Saitama, Japan, 2Dept Obst Gynec, Natl Def Med Col, Saitama,
Japan, 3Dept Urol, Natl Def Med Col, Saitama, Japan, 4Dept Basic Pathol, Natl Def Med Col,
Saitama, Japan, 5R&D HQ, Fuji Film, Kanagawa, Japan

1S07H1-3

階層ベイズ推定法を用いた連続光拡散光トモグラフィの逆問題解法○下川 丈明ATR・脳情報解析研

Hierarchical Bayesian inversion algorithms for continuous-wave diffuse optical
tomography

Posters Day 1

Goro Nishimura

教
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Posters Day 2

Time-domain fluorescence diffuse optical tomography for quantitative imaging
of a fluorescence target in deep biological tissue

Takeaki Shimokawa

1S07H1-4

Posters Day 3

ATR-NIA, Kyoto, Japan輻射輸送方程式に基づくタイムドメイン拡散光トモグラフィ○星 詳子
浜松医科大・生体医用光学Time-domain diffuse optical tomography based on the radiative transfer
equation
Yoko Hoshi
Dept Biomedical Optics, Hamamatsu Univ Sch Med, Hamamatsu, Japan

101

第94回⽇本⽣理学会⼤会

Aims & Scope
The advent of recent sophisticated optical techniques, such as optogenetics and two-photon microscopy, has been
contributing to elucidation of structures and functions at the microscopic level in mammals. These techniques are
exclusively applied to studies in small animals, cultured tissues and cells. This is partly due to limited penetration depth oflight. In contrast, optical imaging techniques using near-infrared light, which relatively easily penetrates biological tissues,
are potentially effective for investigating human anatomy and physiology. Using scattered lights, diffuse optical
tomography (DOT) reconstructs images of absorption and scattering coefficients, which provide information about
hemodynamics and structures. The DOT image reconstruction can be approximately divided into two kinds: one is alinearization approach (linear DOT) and another is a nonlinear iterative approach (nonlinear iterative DOT). DOT can beextended to fluorescence tomography (FDOT), which enables molecular imaging in human. Photoacoustic imaging (PAI) is
based on the PA effect, the generation of acoustic waves by the absorption of optical waves. In this symposium, the four
above-mentioned imaging modalities are presented, and their potential as a tool for investigating human anatomy andphysiology is discussed.

102

The 94th Annual Meeting of the Physiological Society of JapanI 会場  Symposium 8

公募シンポジウム 8Hall I

Lectures

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

筋生理学の最前線：筋形成、筋疾患の分子機構

Frontiers in skeletal muscle physiology:
molecular mechanism of myogenesis and myopathies

Symposia

オーガナイザー・Organizer：
林 由起子（東京医科大学 病態生理学分野）
Yukiko K. Hayashi (Dept Pathophysiol, Tokyo Medical Univ)
村山 尚（順天堂大学医学部 薬理学分野）
Takashi Murayama (Dept Pharmacol, Juntendo Univ Sch Med)

1S08I1-1リン脂質フリッパーゼの筋管形成における役割○原 雄二1,2，土谷 正樹1，伊藤 可梨1，奥田 雅貴1，西岡 諒太郎1，梅田 眞郷1
1京大・院工・合成・生物，2日本医療研究開発機構, PRIME

The role of phospholipid flippases in myotube formation

Yuji Hara1,2, Masaki Tsuchiya1, Karin Itoh1, Masaki Okuda1, Ryotaro Nishioka1,
Masato Umeda1
1Dept Synth Chem & Biol Chem, Kyoto Univ, Kyoto, Japan, 2PRIME

1S08I1-2

骨格筋と心筋の筋原線維形成の分子機構とその不全による筋疾患○遠藤 剛，高野 和儀

教
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千葉大・院理・生物

Posters Day 1

Molecular mechanisms of myofibrillogenesis in skeletal and cardiac muscles
and muscle diseases caused by their failure
Takeshi Endo, Kazunori Takano
Dept Biol, Grad Sch Sci, Chiba Univ, Chiba, Japan

1S08I1-3

ミオパチーのエキソーム解析○宮武 聡子1,2
1横浜市大附属病院・遺伝子診療部，2横浜市大・院医・遺伝学

Posters Day 2

Whole exome sequencing in congenital myopathy
Satoko Miyatake1,2

1Dept Clinical Genet, Yokohama City Univ Hospital, Yokohama, Japan, 2Dept Human Genet,

Yokohama City Univ Grad Sch Med, Yokohama, Japan

筋原線維配列の乱れとタンパク質凝集体を伴う筋疾患○林 由起子
東医大・医・病態生理

Myopathies associated with myofibril disorganization and protein aggregation

Posters Day 3

1S08I1-4

Yukiko K Hayashi
Dept Pathophysiol, Tokyo Medical Univ, Tokyo, Japan

103

第94回⽇本⽣理学会⼤会

1S08I1-5

RyR1関連筋疾患の分子機構：診断と治療に向けて○村山 尚
順天堂大・医・薬理Molecular mechanism of RyR1-related muscle diseases: toward diagnosis andtherapy
Takashi Murayama
Dept Pharmacol, Juntendo Univ Sch Med, Tokyo, Japan

Aims & Scope
For the proper development and effective force generation, skeletal muscle has various excellent and special physiologicalsystems. Lots of previous works have revealed the ingenious and precise molecular mechanisms of the myogenesis andmuscle contraction. Further, recent advances in molecular genetics identified many causative genes for myopathies and themolecular pathomechanisms of each disease are becoming to be clarified.
This symposium will provide new insights into the myogenesis and myopathies, including the roles of membrane
phospholipid translocases which produce asymmetrical distribution of phospholipids of plasma membrane, precise
mechanisms of thin filament formation, and clinical and molecular pathophysiology of muscle diseases associated withsarcomere components and T-tubule–sarcoplasmic reticulum system.

104

The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 9

J 会場  Symposium 9

Hall J

Lectures

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50

リハビリテーションと脳機能計測

Rehabilitation and functional brain imaging

黒澤 美枝子（国際医療福祉大学）
Kurosawa Mieko (International University of Health Welfare)

1S09J1-1

Non-invasive brain machine interfaces for assistive and rehabilitation robotics
Giuseppe Lisi, Jun Morimoto

Symposia

オーガナイザー・Organizer：
松川 寛二（広島大学）
Matsukawa Kanji (Hiroshima University)

Dept Brain Robot Interface, Comput Neurosci Lab, ATR Inst, Kyoto, Japan

ニューロリハビリテーションにおけるfNIRSの臨床応用
教
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○宮井 一郎
森之宮病院・神経リハ研

Clinical application of functional near-infrared spectroscopy inneurorehabilitation
Ichiro Miyai
Neurorehab Res Inst, Morinomiya Hosp, Osaka, Japan

Posters Day 1

再生医療におけるPETを用いたイメージングの活用○尾上 浩隆理研・CLST・生体機能評価

Positron emission tomography (PET) molecular and functional imaging forregenerative medicine
Hirotaka Onoe
RIKEN Center for Life Science Technologies, Kobe, Japan

1S09J1-4

運動開始前にみられる前頭前野酸素化ヘモグロビン濃度の増加とセントラルコマンド○松川 寛二，石井 圭，浅原 亮太，遠藤 加菜，梁 楠
広島大学・医学部保健学科・生理

Increased oxygenation of the prefrontal cortex prior to the onset of exercise has
relation to central command
Kanji Matsukawa, Kei Ishii, Ryota Asahara, Kana Endo, Nan Liang
Dept Integrative Physiol, Grad Sch Biomed & Health Sci, Hiroshima Univ, Hiroshima, Japan

Aims & Scope
Japan is now considered a highly-aged society and elderly people may suffer brain injury or damage due to stroke andneuro-degeneration disease. So it is important for compensating or recovering the brain function from the injury or
damage to promote evidenced-based rehabilitation. To do this, brain activity should be recorded in the course of
rehabilitation and understanding how injury or degeneration of brain tissue may alter physiological functions and what kindof the plastic changes in the brain may occur is needed. In this symposium, we would like to focus on the evidence andrecent progress of functional brain imaging to estimating brain activity using different imaging techniques (NIRS, f-MRI,
PET, and EEG). Each speaker will present their state-of-the-art data about in-vivo brain imaging during behaviors in normal
and disabled subjects. Drs. Kurosawa and Matsukawa have been organizing the rehabilitation-related symposiums since
the 89th Annual meeting of the Physiological Society in 2012 from various aspects (autonomic function, endocrine function,
cerebral blood flow regulation, integrative function facing aging, brain plasticity after stroke etc.).
105

Posters Day 2

1S09J1-3

Posters Day 3

1S09J1-2

第94回⽇本⽣理学会⼤会

公募シンポジウム 10

C 会場  Symposium 10

Hall C

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

DOHaD研究から先制医療への展望

Developmental origins of health and disease (DOHaD) research:
perspective toward preemptive medicine
オーガナイザー・Organizer：
根本 崇宏（日本医科大学生理学 生体統御学）
Takahiro Nemoto (Dept Physical, Nippon Medical School)
伊東 宏晃（浜松医科大学付属病院 周産期母子センター）
Hiroaki Itoh (Dept Obstetrics Gynecol, Hamamatsu Univ Sch Med)

1S10C2-1

胎生期低栄養の次世代への影響○根本 崇宏，柿沼 由彦
日本医大・生体統御学

Impact on fetal malnutrition of the next generation
Takahiro Nemoto, Yoshihiko Kakinuma
Dept Physical, Nippon Medical School, Tokyo, Japan

1S10C2-2

Maternal stress causes loss of parvalbumin neurons and alterations of
extracellular glycans in the mPFC of GAD67-GFP knock-in mouse

Tianying Wang1, Adya Saran Sinha1, Yuchio Yanagawa2, Kenichiro Hata3,
Atsuo Fukuda1
1Dept Neurophysiol, Hamamatsu Univ Sch Med, Hamamatsu, Japan, 2Dept Genet Behav Neurosci,
Gunma University Grad Sch Med, Maebashi, Japan, 3Dept Maternal-Fetal Biol, Natl Res Inst Child
Health Dev, Tokyo, Japan

1S10C2-3

胎生期の低栄養と成長後の肝脂肪変性 −小胞体ストレスの関わり−○伊東 宏晃浜松医大・周産母子センター

Undernourishment in utero and hepatic steatosis in later life; a possible
involvement of endoplasmic reticulum stressHiroaki Itoh
Dept Obstetrics Gynecol, Hamamatsu Univ Sch Med, Hamamatsu, Japan

1S10C2-4

早産低出生体重児における脂肪組織の発達とインスリン抵抗性○中野 有也
昭和大学・医学部・小児科

Fat tissue development and insulin resistance in preterm low-birth-weight
infants
Yuya Nakano
Dept Pediatrics, Showa Univ Sch Med, Tokyo, Japan

Aims & Scope
The mean birth weight has been declining, and the prevalence rate of low birth weight has increased from 1980s in Japan.
According to developmental origins of heath and disease (DOHaD) theory, which is based on the early epidemiologicalstudy carriedout by David Barker, low birth weight is known to be a risk factor of developing noncommunicable diseases(NCDs). The recent increase in low birth weight infants in Japan might be a social burden in the future and to solve theproblem is a matter ofgreat urgency. Timely interventions may reduce the risk of developing NCDs in individuals and also
limit its transgeneration. Therefore, it is necessary to understand the mechanisms underlying developing NCDs in low birthweight infants. We also need to adopt a preemptive approach that seeks to assess NCDs risk in order to perform earlyintervention and interrupt the development of NCDs. Moreover, we have to inform widely this DOHaD theory. The aim of
this symposium is to address recent challenges and to present novel approaches to clarify the mechanisms underlying
developing NCDs in low birth weight infants including new insights from basic science to clinical medicine.
106The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 11

D 会場  Symposium 11

Hall D

Lectures

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

日本生物物理学会連携シンポジウム
生物物理学的手法による生理学研究の新展開

Joint Symposium with the Biophysical Society of Japan
New horizons in physiology employing biophysical technologies

Symposia

オーガナイザー・Organizer：
福田 紀男（東京慈恵会医科大学 細胞生理学講座）
Norio Fukuda (Dept Cell Physiol, Jikei Univ Sch Med)安田 賢二（早稲田大学理工学術院 先進理工学部・物理学科）
Kenji Yasuda (Dept Physics, Waseda Univ)

1S11D2-1

アクチン線維の細胞内、細胞外構造解析○成田 哲博名古屋大・院理Structural analysis of the actin filament in vivo and in vitro
Akihiro Narita
Grad Sch Sci, Nagoya Univ, Nagoya, Japan

1S11D2-2

リバースジャイレースというDNAの二重鎖をきつく巻き上げる分子機械の一分子解析○小川 泰策

教
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理研・QBiC

Posters Day 1

Single-molecule analysis of DNA overwinding by reverse gyrase
Taisaku Ogawa
RIKEN QBiC, Osaka, Japan

顕微力学操作による細胞分裂機構のメカノケミカル制御○板橋 岳志1,2，石渡 信一1
1早大・理工・物理，2早大・WABIOS

Posters Day 2

Mechano-chemical control of cell division machinery by using
micromanipulation
Takeshi Itabashi1,2, Shinichi Ishiwata1

1Dept Phys, Fac Sci Eng, Waseda Univ, Tokyo, Japan, 2WASEDA Biosci Res Inst Singapore(WABIOS), Waseda Univ, Singapore, Singapore

1S11D2-4

マイクロファブリケーション技術を用いた人工神経回路構築技術○寺薗 英之1，服部 明弘1,2，安田 賢二1,2
1早大・総研機構・WABIOS，2早大･物理Construction of an artificial neuronal circuit using a microfabrication technique
Hideyuki Terazono1, Akihiro Hattori1,2, Kenji Yasuda1,2

1WASEDA Biosci Res Inst Singapore (WABIOS), Waseda Univ, 2Dept Physics, Waseda Univ, Tokyo,

Japan

107

Posters Day 3

1S11D2-3

第94回⽇本⽣理学会⼤会

1S11D2-5数理モデルによる心筋細胞の集団効果の解析○林 達也1，時弘 哲治1,2，栗原 裕基2,3，野村 典正4，安田 賢二2,5
1 東大院・数理，2 科学技術振興機構 , CREST，3 東京大学大学院医学系研究科，4 東京医科歯科大学生体材料工学研究所，5早稲田大学理工学術院

Analysis of the community effect of cardiomyocytes by mathematical modeling
Tatsuya Hayashi1, Tetsuji Tokihiro1,2, Hiroki Kurihara2,3, Fumimasa Nomura4,
Kenji Yasuda2,5

1Grad Sch Math Sci, Univ Tokyo, Tokyo, Japan, 2JST, CREST, Saitama, Japan, 3Grad Sch Med,
Univ Tokyo, 4Inst Biomat Bioeng, Tokyo Med Dent Univ, Tokyo, Japan, 5Fac Sci Eng, Waseda Univ,
Tokyo, Japan

1S11D2-6（AP3）マウス心臓における興奮収縮連関のナノイメージング○小比類巻 生，福田 紀男
慈恵医大・医・細胞生理

In vivo cardiac nano-imaging high-resolution analysis of excitation-contraction
coupling in the heart
Fuyu Kobirumaki, Norio Fukuda
Dept Cell Physiol, Jikei Univ Sch Med, Tokyo, Japan

Aims & Scope
For a complete understanding of the system dynamics of life, it is imperative to uncover the mechanisms of various cellularand sub-cellular functions based on physics (single-molecule dynamics, intracellular transport and localization of cellularcomponents, cell motility and cellular adaptation to external force); in doing so, a new era in physiology is brought forth.
This symposium brings together young scientists across Japan applying cutting-edge biophysical technologies in various
life science fields. We will discuss 1) structure determination of actin filament, 2) single molecular analysis of motor proteins,3) micromanipulation of cellular division, 4) experimental analysis and mathematical modeling of cell-cell communications,and5) nano-imaging of sarcomeric contraction in the heart in vivo.

108

The 94th Annual Meeting of the Physiological Society of JapanE 会場  Symposium 12

Hall E

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

イオンチャネル・トランスポータ分子の構造・動態・機能のシミュレーション研究

Simulation studies of structures, dynamics, and functions of ion channels and transporters

Lectures

公募シンポジウム 12

竹内 綾子（福井大学学術研究院 医学系部門・統合生理学）
Ayako Takeuchi (Integr Physiol Fac Med Sci, Univ Fukui)

1S12E2-1

コンピュータシミュレーションによって原子レベルで撮影されたイオンチャネルを通る
イオン透過の3D動画

Symposia

オーガナイザー・Organizer：
藤原 祐一郎（大阪大学医学系研究科 生理学講座）
Yuichiro Fujiwara (Dept Physiol, Grad Sch Med, Osaka Univ)○炭竈 享司，老木 成稔
福井大・医・分子生理

A 3-D movie of ion permeation through ion channel at the atomic level filmedby computer simulation
Takashi Sumikama, Shigetoshi Oiki
Facult Med Sci, Univ Fukui, Japan

1S12E2-2

粗視化シミュレーションによるアンキリンGの細胞膜周辺での動態の解析○近藤 寛子1，藤原 祐一郎2，城田 松之3,4,5，木下 賢吾4,5,6

教
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A study of dynamics of palmitoylated Ankyrin-G around a lipid bilayer by coarsegrained simulations

Hiroko X Kondo1, Yuichiro Fujiwara2, Matsuyuki Shirota3,4,5, Kengo Kinoshita4,5,6
1Grad Sch Info Sci, Hiroshima City Univ, Hiroshima, Japan, 2Dept Physiol, Grad Sch Med, Osaka
Univ, Suita, Japan, 3Grad Sch Med, Tohoku Univ, Sendai, Japan, 4Grad Sch Info Sci, Tohoku Univ,
Sendai, Japan, 5ToMMo, Tohoku Univ, Sendai, Japan, 6IDAC, Tohoku Univ, Sendai, Japan

リンパ球におけるミトコンドリア-小胞体Ca2+ クロストークの役割に関するフィジオー
ム研究

Posters Day 2○竹内 綾子1，金 鳳柱2，松岡 達1
1福井大・医・統合生理，2ソウル大・歯Physiome study on the roles of mitochondria-endoplasmic reticulum Ca2+
crosstalk in lymphocytes
Ayako Takeuchi1, Bongju Kim2, Satoshi Matsuoka1

1Integr Physiol Fac Med Sci, Univ Fukui, Japan, 2Dent Hosp Seoul Natl Univ, Korea

1S12E2-4

Kir2.1内向き整流性K+チャネルの細胞外K+に依存するK+透過と開閉のメカニズム○柳（石原）圭子1，松岡 達2，鷹野 誠1
1久留米大・医・生理・統合自律，2福井大・医・統合生理Mechanisms for external K+ dependence of K+ permeation and gating of Kir2.1
inward rectifier K+ channel
Keiko Ishihara1, Satoshi Matsuoka2, Makoto Takano1

1Dept Physiol, Kurume Univ Sch Med, Kurume, Japan, 2Dept Integ System Physiol, Fac Med Sci,
Univ Fukui, Japan109

Posters Day 3

1S12E2-3

Posters Day 1

1広市大・院情報，
2阪大・院医・生理，
3東北大・院医，
4東北大・院情報，
5東北大・メガバンク，
6東北大・加齢研第94回⽇本⽣理学会⼤会

Aims & Scope
Ion channels and transporters play key roles in the physiology of a wide range of cells, especially in membrane excitationand ionic homeostasis. They have been successfully analyzed by electrophysiology in combination with diverse approaches(molecular genetics, structural biology, imaging, etc.), but there are still sotme aspects the experimental analysis of which
are technically difficult. For example, understandings of molecular structural dynamics, inter molecular functional couplings
and integration of cellular function are still insufficient. Simulation study can become a powerful tool to overcome suchdifficulties. In particular, simulation approaches based on the mathematical modeling and the statistical mechanics rather
than on the genetic network are important. A wide range of computational approaches is also required in an attempt torelate the 3D structure to the physiological function. In this symposium, we will introduce our computational approaches
focusing on ion channels and transporters, in each hierarchy from the atomic to the cellular level. The symposium will also
cover the theoretical backgrounds and practical examples of simulation analysis combined with other techniques that willbring deep and novel understandings of membrane physiology.

110

The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 13

F 会場  Symposium 13

Hall F

Lectures

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

心臓におけるCa2+シグナル最前線 −分子から病態まで−

Forefront of Ca2+ signaling in the heart– from molecules to diseases –Symposia

オーガナイザー・Organizer：
西谷（中村）友重（国立循環器病研究センター・分子生理部）
Tomoe Y. Nakamura-Nishitani (Dept Mol Physiol, Natl Cereb Cardiovasc Ctr)
呉林 なごみ（順天堂大学医学部 薬理学教室）
Nagomi Kurebayashi (Dept Pharmacol, Facl Med, Juntendo Univ)

1S13F2-1

Angiotensin IIによる幼若心筋細胞のCaV1.2L型Ca2+チャネル活性化の分子機構○柏原 俊英，中田 勉，山田 充彦
信州大・医・分子薬理Angiotensin II activates L-type CaV1.2 Ca2+ channels in immature
cardiomyocytes
Dept Mol Pharmacol, Shinshu Univ Sch Med, Matsumoto, Japan

1S13F2-2心臓の線維化におけるTRPC3-Nox2機能連関の役割○冨田 拓郎1,2，北島 直幸3，西村 明幸1,2，西田 基宏1,2,3,4
1岡崎統合バイオ（生理研），2総研大，3九大院・薬，4JSTさきがけ

Functional and physical coupling between TRPC3 and Nox2 underlies
maladaptive cardiac fibrosis
Takuro Numaga-Tomita1,2, Naoyuki Kitajima3, Akiyuki Nishimura1,2,
Motohiro Nishida1,2,3,4

1Okazaki Inst Integr BioSci (Natl Inst Physiol Sci), Okazaki, Japan, 2Sokendai, 3Grad Sch Pharm

Sci, Kyushu Univ, Fukuoka, Japan, 4JST, PRESTO

1S13F2-3

心臓の可塑性におけるTRPV2の役割○片野坂 友紀

Posters Day 1

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Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada

岡山大院・医歯薬・システム生理

Posters Day 2

TRPV2 is required for the normal cardiac plasticity
Yuki Katanosaka
Dept Carddiovascular Physiol, Okayama Univ, Okayama, Japan

Ca2+センサー NCS-1による新規心筋ストレス防御機構○西谷（中村）友重1，中尾 周1，若林 繁夫2
1国循セ・研・分子生理，2大阪医・薬理Novel mechanism of stress tolerance of cardiomyocytes by a Ca2+ sensor
protein NCS-1

Posters Day 3

1S13F2-4

Tomoe Nishitani-Nakamura1, Shu Nakao1, Shigeo Wakabayashi2

1Dept Mol Physiol, Natl Cer Cardiovasc Ctr, Osaka, Japan, 2Dept Pharmacol, Osaka Med Univ,
Osaka, Japan

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Aims & Scope
Intracellular Ca2+ regulates various cellular processes such as muscle contraction via excitation-contraction (E-C) coupling,
and gene expression, leading to cardiac remodeling. There are a number of Ca2+ regulatory proteins, such as Ca2+permeable channels and Ca2+ sensors. Dysregulation of Ca2+ signals caused by functional impairments of these proteinswould lead to life-threatening arrhythmia, hypertrophy and heart failure. However, detailed molecular mechanisms
underlying these disease conditions are still not fully understood. In this symposium, we will focus on some of Ca2+
regulatory proteins, particularly the L-type Ca2+ channel, TRPC3 channel, TRPV2 channel and neuronal Ca2+ sensor NCS-1,
that are known to be important for E-C coupling and/or cardiac remodeling. We will present our current understanding of
how acute and chronic cardiac disorders occur by showing our recent data. We will also discuss possible crosstalk of Ca2+
regulations mediated by these proteins.

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H 会場  Symposium 14

公募シンポジウム 14

Hall H

Lectures

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

シナプス分布による神経情報制御の最前線

Roles of synaptic input distribution in neuronal signal processing

1S14H2-1

聴覚同時検出における非線形シナプス統合の役割○山田 玲，久場 博司
名古屋大・院医・細胞生理学

Sublinear integration at local dendrite of auditory coincidence detector neurons

Symposia

オーガナイザー・Organizer：
久場 博司（名古屋大学・医院・細胞生理学）
Hiroshi Kuba (Dept Cell Physiol, Grad Sch Med, Nagoya Univ)

Rei Yamada, Hiroshi Kuba
Dept Cell Physiol, Grad Sch Med, Nagoya Univ, Nagoya, Japan

1S14H2-2大脳皮質各種神経細胞へのシナプス入力○窪田 芳之1,2
1生理研，2総研大Synapse density and estimated number on various neurons of the rat frontal
cortex
Yoshiyuki Kubota1,2

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1S14H2-3大脳小脳連関に関与する小脳皮質のシナプス入力分布○石川 太郎，志牟田 美佐
慈恵医大・薬理Synaptic input distribution in the cerebellar cortex related to cerebro-cerebellar
communication
Taro Ishikawa, Misa Shimuta

Posters Day 1

1Div Cerebral Cir, Nat Inst Physiol Sci, Okazaki, Japan, 2SOKENDAI, Okazaki, Japan

樹状突起による上流ニューロン集団の選定○池谷 裕二東大・院薬

Dendrites screen presynaptic neuron ensembles
Yuji Ikegaya
Grad Sch Pharmaceut Sci, Univ Tokyo, Japan

Aims & Scope
Spatial pattern of synaptic inputs has strong impact on their integration at dendrites. Recent studies have revealed that thiseffect is more complex than previously thought, and plays a critical role in determining neuronal output. For example,
synaptic integration is augmented with accumulation of inputs within dendrites via supra-linear summation in cortical andhippocampal pyramidal neurons, whereas it is suppressed via sub-linear summation in inhibitory interneurons andbrainstem auditory neurons. In this symposium, top researchers in this field will get together and discuss their up-to-datefindings on the issues. Through the discussion, we will explore logics and strategies of determining synaptic distribution atdendrites in the nervous system.

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Posters Day 3

1S14H2-4

Posters Day 2

Dept Pharm, Jikei Univ Sch Med, Tokyo, Japan

第94回⽇本⽣理学会⼤会

公募シンポジウム 15

I 会場  Symposium 15

Hall I

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

in vivo 生理学：その観察と操作

in vivo physiology: observation and manipulation of biological activity
オーガナイザー・Organizer：
中村 渉（大阪大学 歯学研究科）
Wataru Nakamura (Lab Oral Chronobiol, Grad Sch Dent, Osaka Univ)
山中 章弘（名古屋大学環境医学研究所 神経系分野2）
Akihiro Yamanaka (Dep Neurosci II, Res Inst Environ Med, Nagoya Univ)

1S15I2-1性周期を制御するサーカディアンリズムの加齢変化○中村 渉
大阪大・院歯・口腔時間生物

Effects of aging on circadian pacemakers for regulating reproductive functions
Wataru Nakamura
Lab Oral Chronobiol, Grad Sch Dent, Osaka Univ, Osaka, Japan

1S15I2-2

加齢による概日リズム機能低下の神経機構○中村 孝博
明治大・農・動物生理

Neural mechanisms of age-related decline in circadian rhythmicity
Takahiro Nakamura
Lab Animal Physiol, Sch Agri, Meiji Univ Kanagawa, Japan

1S15I2-3

新規技術によってみえてくる科学的現象の新しい局面○沼野 利佳1，澤畑 博人3，安東 頼子2，河野 剛士3
1豊橋技科大・環境生命工，2豊橋技科大・アイリス，3豊橋技科大・電気電子

The novel technology to observe in vivo physiology gives us new sight behindscientific phenomena
Rika Numano1, Hirohito Sawahata3, Yoriko Ando2, Takeshi Kawano3

1Dept Env Life Sci, TOYOHASHI Univ Tech, Aichi, Japan, 2EIIRIS, TOYOHASHI Univ Tech, Aichi,
3Electrical and Electro Info, TOYOHASHI Univ Tech, Aichi, Japan

1S15I2-4（AP1）

知覚記憶の固定化を担う睡眠時の大脳皮質回路○宮本 大祐1,2,3,4，平井 大地2，ファン アラン チチュン5，犬束 歩1，小田川 摩耶2，
ボーリンガー ローマン6，アダイカン チナカルパン6，松原 智恵2，松木 則夫3，
深井 朋樹5，マクヒュー ジェイ トーマス6，山中 章弘1，村山 正宜2
1名大・環医研・神経系II，2理研BSI・行動神経生理学，3東大院・薬・薬品作用学，4学振特別研究員PD，
5理研BSI・脳回路機能理論，6理研BSI・神経回路、行動生理学

Cerebral cortex circuits for perceptual memory consolidation during sleep

Daisuke Miyamoto1,2,3,4, Daichi Hirai2, Chi-Chung Alan Fung5, Ayumu Inutsuka1,
Maya Odagawa2, Roman Boehringer6, Adaikkan Chinnakkaruppan6,
Chie Matsubara2, Norio Matsuki3, Tomoki Fukai5, Thomas J Mchugh6,
Akihiro Yamanaka1, Masanori Murayama2
1Dep Neurosci II, Res Inst Environ Med, Nagoya Univ, Nagoya, Japan, 2Lab Behav Neurophysiol,

RIKEN Brain Science Inst, Wako, Japan, 3Lab Chemi Pharmacol, Grad Sch Pharm Sci, Univ Tokyo,
Tokyo, Japan, 4JSPS Research Fellow, Tokyo, Japan, 5Lab Neural Circuit Theory, RIKEN Brain
Science Inst, Wako, Japan, 6Lab Circuit Behav Physiol, RIKEN Brain Science Inst, Wako, Japan

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1S15I2-5

記憶痕跡の観察と操作○松尾 直毅Lectures

阪大・院医・分子行動神経科学

Observation and manipulation of memory engram
Naoki Matsuo
Dept Mol & Behav Neurosci, Grad Sch Med, Osaka Univ, Osaka, Japan

1S15I2-6視床下部神経活動の記録と操作による睡眠覚醒と記憶の制御機構の解明○山中 章弘Akihiro Yamanaka
Dept Neurosci II, Res Inst Environmental Med, Nagoya Univ, Nagoya, Japan

Symposia

名古屋大・環境医学研・神経2

Regulatory mechanism of sleep⁄wakefulness and memory by measuring andmanipulating the activity of hypothalamic neurons

Aims & Scope

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Posters Day 3

Posters Day 2

Posters Day 1

Physiology is the scientific study of normal functions in living organisms, and focuses on how hierarchical systems, i.e.,organs, tissue, cells, and biomolecules, carry out the chemical or physical functions present in a living system. In this
symposium, we will discuss how to examine these physiological functions, along with time-associated variations such as
mammalian memory, sleep, and biological rhythms. Recent progress in each subject enables us to conduct detailed
observation and manipulation of in vivo systems by means of the latest opto-, toxi- and biochemical genetic techniques,using time-dependent environmental cues. This symposium will provide an understanding of the essential meaning of invivo physiology, by using live observation and dynamic manipulation of physiological functions.

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公募シンポジウム 16

J 会場  Symposium 16

Hall J

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40

健康状態と病態形成における亜鉛恒常性と亜鉛シグナリングの役割

Zinc homeostasis and signaling in health and disease
オーガナイザー・Organizer：
深田 俊幸（徳島文理大学薬学部 病態分子薬理学研究室）
Toshiyuki Fukada (Pharmaceutical Sci, Mol Cell Physiol, Tokushima Bunri Univ)
神戸 大朋（京都大学大学院生命科学研究科 統合生命科学専攻 応用生物機構学講座）
Taiho Kambe (Grad Sch Biostudies, Kyoto Univ)

1S16J2-1

Role of zinc transporters and signaling in homeostasis of epitheliual tissues
Toshiyuki Fukada
Pharmaceutical Sci, Mol Cell Physiol, Tokushima Bunri Univ, Tokushima, Japan

1S16J2-2

The zinc spark is a non-invasive marker of mammalian egg and embryo quality
Nan Zhang1, Francesca E Duncan1, Emily L Que1,2, Thomas V OHalloran3,
Teresa K Woodruff1

1Dept Obstet Gynecol, Northwestern Univ, Illinois, USA, 2Dept Chem Biochem, Univ Texas atAustin, USA, 3Dept Chem, Northwestern University, Illinois, USA

1S16J2-3

気道上皮細胞における亜鉛取り込み輸送体ZIP2の新規スプライススイッチが閉塞性肺疾
患の肺病態を調節する○首藤 剛1，亀井 竣輔1,2，首藤 恵子3，スイコ メリーアン1，甲斐 広文1
1熊本大・院薬・遺伝子機能応用学，2熊大院・リーディング大学院・HIGO，3崇城大・薬・薬理学

A novel splicing switch of zinc importer ZIP2 in airway epithelial cells that
controls the pathology of obstructive lung diseases

Tsuyoshi Shuto1, Shunsuke Kamei1,2, Keiko Ueno-Shuto3, Mary-Ann Suico1,
Hirofumi Kai1
1Dept Mol Med, Grad Sch Pharm Sci, Kumamoto Univ, Kumamoto, Japan, 2Prog Leading Grad Sch

HIGO, Kumamoto Univ, Kumamoto, Japan, 3Lab Pharmacol, Sojo Univ Pharm Sch, Kumamoto,Japan

1S16J2-4

メタロチオネインと加齢性疾患○川上 隆茂，門田 佳人，佐藤 政男，鈴木 真也
徳島文理大・薬・公衆衛生

Metallothionein and age-related diseases
Takashige Kawakami, Yoshito Kadota, Masao Sato, Shinya Suzuki
Fac Pharm Sci, Tokushima Bunri Univ Tokushima, Japan

1S16J2-5

ZnTトランスポーターによる亜鉛要求性酵素の活性化○神戸 大朋京大・院生命科学・統合生命

Zinc-requiring ectoenzyme activation by ZnT transporters
Taiho Kambe
Grad Sch Biostudies, Kyoto Univ, Kyoto, Japan

Aims & Scope
Zinc is an essential trace element for life, and recent studies revealed that zinc acts as a signaling factor: zinc signal, which ismediated bytransporters, channels, and metallothioneins, is involved in health and disease conditions. This symposium will
aim to discuss the roles of zinc signaling and its related molecules in physiology and pathogenesis, by inviting experts
including Prof. Dr. Kathy Taylor, who is the President Elect of International Society for Zinc Biology (ISZB).
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公募シンポジウム 17

D 会場  Symposium 17

Hall D

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

食嗜好の分子神経基盤

Molecular and neural basis for food preferences

Symposia

オーガナイザー・Organizer：
佐々木 努（群馬大学生体調節研究所 代謝シグナル解析分野）
Tsutomu Sasaki (Metabolic Signal, IMCR, Gunma Univ)
岡本 士毅（自然科学研究機構生理学研究所 生殖・内分泌系発達機構研究部門）
Shiki Okamoto (Div Endocrinol Metab, NIPS)

2S17D1-1

空腹による味覚感受性の変化を制御する脳部位の探索○中島 健一朗，傅 欧，岩井 優，三坂 巧
東大院農・応用生命化学

Hypothalamic regulation of hunger-induced changes in taste sensitivities
Ken-ichiro Nakajima, Ou Fu, Yuu Iwai, Takumi Misaka

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Dept Appl Biol Chem, Grad Sch Agri Life Sci, Univ Tokyo, Tokyo, Japan

2S17D1-2視床下部室傍核AMPKは食物嗜好性を調節する○岡本 士毅，佐藤 達也，箕越 靖彦
生理研・生殖内分泌系発達機構

AMPK in the paraventricular hypothalamic nucleus regulates food selection
behavior between fat and carbohydrate diet

Posters Day 1

Shiki Okamoto, Tatsuya Sato, Yasuhiko Minokoshi
Div Endocrinol Metab, NIPS, Okazaki, Japan

2S17D1-3

Sirt1はショ糖食選択行動を制御する○松居 翔，佐々木 努，河野 大輔，橋本 博美，小林 雅樹，北村 忠弘
群大・生調研・代謝シグナル

Sirt1 regulates sucrose diet selection behavior

Posters Day 2

Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Hiromi Yokota-Hashimoto,
Masaki Kobayashi, Tadahiro Kitamura
Metabolic Signal, IMCR, Gunma Univ, Maebashi, Japan

Elovl6欠損マウスはショ糖嗜好性が亢進する○松坂 賢，島野 仁
筑波大・医学医療系・代謝内科

Enhanced high sucrose diet preference in Elovl6 deficient mice
Takashi Matsuzaka, Hitoshi Shimano
Dept Int Med (Endocrinol Metabol), Facl Med, Univ Tsukuba, Japan

Posters Day 3

2S17D1-4

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Aims & Scope
Food preferences influence the decision of “what to eat,” and what we eat strongly influences our health. Therefore
understanding the mechanisms for food preferences is important, yet it remains elusive. Food preferences are made basedon the integration of past experiences and motivations/appetite, which is influenced by sensory inputs and metabolic
signaling. To decipher the complex mechanisms regulating food preferences, multi-disciplinary approaches are necessary.
In this symposium, we will discuss the new mechanisms for food preferences, revealed by new approaches and latest
technologies. Four topics will be discussed: (1) interaction between the central appetite-promoting neurons and thegustatory system; (2) the role of central energy-sensing molecule in affecting food preferences; (3) how hormones andenergy-sensing molecules interact to affect food preferences; and (4) how metabolic enzymes that regulate fatty acids
influence food preferences.
By presenting the latest research results, we would like to encourage other scientists to join the field of food preference
research and help making further progresses in the field, so that we can promote healthy eating behavior and health of
mankind.

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公募シンポジウム 18

E 会場  Symposium 18

Hall E

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

受精プロセスにおける免疫応答の仕組みと働き

Multiple functions of immunity during fertilization

Symposia

オーガナイザー・Organizer：
三輪 尚史（東邦大学医学部 生理学講座 細胞生理学分野）
Naofumi Miwa (Deparment of Physiology, School of Medicine, Toho University)
藤ノ木 政勝（獨協医科大学医学部 生理学（生体制御））Masakatsu Fujinoki (Department of Regulatory Physiology, School of Medicine, Dokkyo Medical University)

2S18E1-1

精漿タンパク質SVS2欠損マウスから見えてきた、精子を殺すメスの免疫機構○河野 菜摘子1，康 宇鎭2，吉田 薫3，吉田 学4，宮戸 健二2
1明治大・農・生命，2国立成育医療研究センター，3桐蔭横浜大学，4東京大学

Seminal vesicle protein SVS2 is required for sperm survival in the uterus
Natsuko Kawano1, Woojin Kang2, Kaoru Yoshida3, Manabu Yoshida4,
Kenji Miyado2

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1Dept Life Sci, Sch Agri, Meiji Univ, Kanagawa, Japan, 2Dept Reprod Biol, NCCHD, 3Toin Univ
Yokohama, 4Univ Tokyo

2S18E1-2

精子不動化抗体による精子運動調節○柴原 浩章兵庫医科大学・産科婦人科

Posters Day 1

Inhibitory effect on sperm movement by sperm immobilizing antibody
Hiroaki Shibahara
Dept Obstet Gynecol, Hyogo, Japan

多精子拒否におけるMMP-2の役割○岩尾 康宏
山口大・院創成・地球生命物質

The role of MMP-2 on polyspermy block at fertilization

Posters Day 2

Yasuhiro Iwao
Div Earth Sci Biol Chem, Grad Sch Sci & Tech for Innov, Yamaguchi Univ, Yamaguchi, Japan

2S18E1-4

マウスの子宮NK細胞は妊娠6日目に減少する○高島 明子1，石川 文雄21東邦大学佐倉病院産婦人科，2東邦大学医学部免疫学講座

Uterine natural killer cells severely decrease in number at gestation day 6 inmice
Akiko Takashima1, Fumio Ishikawa2

1Dept Obstet Gynecol, Toho Univ Med Center, Sakura Hospital, 2Dept Immunol, Toho Univ Sch Med

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Posters Day 3

2S18E1-3

第94回⽇本⽣理学会⼤会

Aims & Scope[Aims] During internal fertilization, sperm properly interact and fuse with an egg, leading to the generation of an embryo
inside the female body. For the female body, spermatozoa are invading “non-self” organisms, and the early embryointernalizes some properties of the “non-self” organism, indicating that the maternal innate immune system tolerates these“non-self” invaders during pregnancy. Therefore, in the field of reproductive physiology, it is important to consider how
innate maternal immunity is related with fertilization. This symposium aims to provide an up-to-date knowledge concerning
immunity and fertilization by introducing recent advances by several leading researchers in this field; this symposium,
together with PSJ members,also aims to discuss future perspectives for this field of study.
[Overviews] We will overview several major topics concerning immunity during fertilization-including (1) the immunologicalresponse against sperm that invade into the uterus and the oviduct; (2) essential roles of immune-related proteins at the
sperm-egg interaction; and (3) the immunological tolerance against embryo implantation-by modern analyses employing
several methods including imaging and electron microscopy studies in addition to physiological and biochemical ones.

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公募シンポジウム 19

F 会場  Symposium 19

Hall F

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

意識の神経メカニズム解明に向けた多面的な実験的アプローチ

Multidisciplinary experimental approaches for elucidatingneural mechanisms of consciousness

Symposia

オーガナイザー・Organizer：
澁木 克栄（新潟大学脳研究所システム 脳生理学分野）
Katsuei Shibuki (Dept Neurophysiol, Brain Res Inst, Niigata Univ)
山田 真希子（量子科学技術研究開発機構放射線医学総合研究所 脳機能イメージング研究部）
Makiko Yamada (Natl Inst Radiol Sci, Natl Inst Quantum Radiol Sci Tch, Japan)

2S19F1-1

こころの錯覚から見た自己意識の神経メカニズム○山田 真希子
量研機構・放医研・脳機能

Neural mechanisms of illusory self-awareness
Makiko Yamada
Brain and mind research team, Dept Functional Brain imaging research, NIRS, QST, Chiba, Japan

2S19F1-2

盲視における視覚と眼球運動○吉田 正俊1,2
1生理研・認知行動発達，2総研大・生理科学

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Masatoshi Yoshida1,2

1Dept System Neurosci, Natl Inst Physiol Sci, Okazaki, Japan, 2Sch Life Sci, Grad Univ Adv Studies,
Hayama, Japan

2S19F1-3

物体の視覚記憶を司るマカクザル大脳皮質の局所回路と大域ネットワークのメカニズム○平林 敏行
量研機構・放医研

Posters Day 2

Cortical microcircuit and large-scale network for visual object memory inprimates
Toshiyuki Hirabayashi
NIRS, QST, Chiba, Japan

マウスを用いた意識の順遺伝学的解析は可能か？
○澁木 克栄新潟大・脳研・生理

Feasibility of forward genetic analysis of consciousness using mouse models
Katsuei Shibuki

Posters Day 3

2S19F1-4

Posters Day 1

Vision and eye movements in blindsight

Dept Neurophysiol, Brain Res Inst, Niigata Univ, Niigata, Japan

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Aims & Scope
Consciousness is one of most important physiological functions of the brain, while only few physiological studies have been
undertaken so far. It is mainly because subjectively-experienced consciousness is a very difficult theme for physiologicalstudies, especially for those depending on animal experiments. However, recent development of artificial intelligenceattracts interest of many people on the differences between the computer and the human brain. Obviously, the presenceor absence of consciousness is one of the most remarkable differences. Difficulties in consciousness studies may beovercome by multidisciplinary studies. In the present symposium, four researchers of consciousness will introduce theirrecent results, which have beenobtained using humans, monkeys, and mice. Human studies are suitable for investigating
intricate aspects of consciousness, and verbal reports of subjectively-experienced consciousness are available. Monkey
studies are ideal for elucidating fine neural mechanisms using invasive techniques such as electrophysiology with electrodepenetration and brain lesioning. In mouse studies, numerous genetically-manipulated strains together with new techniquessuch as optogenetics or two-photon imaging are available. Therefore, it may be possible to make a breakthrough inconsciousness studies by combining the merits of each type of studies. We will discuss about such possibilities in
multidisciplinary studies.

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公募シンポジウム 20

H 会場  Symposium 20

Hall H

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

ニューロリハビリテーションの新戦略

The new strategy in the neurorehabilitation science

Symposia

オーガナイザー・Organizer：
浦川 将（広島大学大学院医歯薬保健学研究院 運動器機能医科学）
Urakawa Susumu (Dept of Musculoskeletal Functional Research and Regeneration, Hiroshima Univ)
西条 寿夫（富山大学大学院医学薬学研究部 システム情動科学）
Nishijo Hisao (System Emotional Science, Univ of Toyama)

2S20H1-1

神経リハビリテーションにおけるニューロモジュレーション技術の応用○三原 雅史1,2
1大阪大・国際医工・臨神医工，2大阪大・院医・神経内科

Clinical application of neuromodulation technique in neurorehabilitation

2S20H1-2

外界からの刺激がもたらす機能改善と神経ネットワーク機構○浦川 将1,2，大田 裕也2，高本 考一3，石黒 幸治2，小野 武年3，西条 寿夫2
1広島大・院医・運動器機能医科学，2富山大・院医・システム情動科学，3富山大・院医・神経整復学講座

Functional improvement via external stimuli and the neuronal network in thebrain

Susumu Urakawa1,2, Yuya Ota2, Koichi Takamoto3, Kouji Ishikuro2,
Taketoshi Ono3, Hisao Nishijo2

1Dept Musculoskeletal Funct Res & Regen, Grad Sch Biomed & Health Sci, Hiroshima Univ,

Hiroshima, Japan, 2Dept Syst Emo Sci, Grad Sch Med & Pharm Sci, Univ Toyama, Toyama, Japan,
3Dept Judo Neurophysiotherapy, Grad Sch Med & Pharm Sci, Univ Toyama, Toyama, Japan

2S20H1-3

運動学習には一次運動野ニューロンに対する一時的な抑制低下と持続的な興奮性シナプ
スの強化が必要である○木田 裕之，美津島 大
山口大・医・神経生理

Motor training promotes both synaptic and intrinsic plasticity of layer II/III
pyramidal neurons in the primary motor cortex
Hiroyuki Kida, Dai Mitsushima
Dept Physiol, Grad Sch Med, Yamaguchi Univ, Ube, Japan

2S20H1-4

不安・抑うつ行動に対するトレッドミル運動の効果（比較的軽度なストレスにより作成
され るモデルラットを用いた検討）○石田 和人，小池 航平，丸山 彰子，上西 祐貴，若山 聡夢，杉山 佳隆
名古屋大・院医・リハ療法学

Anxiety/depressive-like behaviors without the change of the HPA axis by mild
stress can be improved treadmill exercise in rats
Kazuto Ishida, Kohei Koike, Akiko Maruyama, Yuki Uenishi, Satomu Wakayama,
Yoshitaka Sugiyama
Dept Phys and Occup Ther, Grad Sch Med, Nagoya Univ, Nagoya, Japan

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Posters Day 1

Med Osaka Univ, Osaka, Japan

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Posters Day 2

1Div Clin Neuroeng, Global ctr MEI, Osaka Univ Osaka, Japan, 2Dept Neurol, Osaka Univ, Grad Sch

Posters Day 3

Masahito Mihara1,2

第94回⽇本⽣理学会⼤会

Aims & Scope
In clinical rehabilitation, it is important for the recovery from the motor dysfunction to intervene via external stimuli or
repetition of motor tasks. Recently, newly rehabilitative interventions have been developed, such as robot mediatedexercises, BMI (brain-machine interface), and so on. Moreover neuronal mechanisms underlying the recovery following therehabilitative interventions have been investigated in detail. In this symposium, we will focus on these interventions andneuronal mechanisms, and that will lead to understanding the new strategy of the neurorehabilitation.

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公募シンポジウム 21

I 会場  Symposium 21

Hall I

Lectures

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

酸化ストレスに対する生理機能を知る 〜低酸素実験から〜

Hypoxic study to identify effects of oxidative stress on physiological function

2S21I1-1

Symposia

オーガナイザー・Organizer：
小河 繁彦（東洋大学）
Shigehiko Ogoh (Toyo Univ)

低酸素が骨格筋特性に及ぼす影響○橋本 健志，大崎 智彦
立命館大学スポーツ健康科学部

The effect of hypoxia on skeletal muscle characteristic
Takeshi Hashimoto, Tomohiko Osaki
Facl Sport Health Sci, Ritsumeikan Univ, Shiga, Japan

2S21I1-2

教
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低酸素環境下での運動が認知機能に及ぼす影響○安藤 創一
電通大・情報理工学研究科

Cognitive function during exercise under hypoxia
Soichi Ando
Dept Mechanical Engineering Intelligent Systems, UEC, Tokyo, Japan

低酸素環境における呼吸筋活動の増加による運動時の循環調節への影響

Posters Day 1

2S21I1-3○片山 敬章1,2
1名大・保体，2名大・院医An increase in respiratory muscle activity affects cardiovascular regulation
during exercise under hypoxic conditions
Keisho Katayama1,2

1Res Heath Phy Fit Sports, Nagoya Univ, Nagoya, Japan, 2Grad Sch Med, Nagoya Univ, Japan

低酸素環境下における脳循環調節

Posters Day 2

2S21I1-4○小河 繁彦東洋大学

Cerebral blood flow regulation during hypoxia
Shigehiko Ogoh
Toyo Univ, Saitama, Japan

Oxidative stress, as one of the inside and outside environmental factors, is known to have a major impact on human healthand physiology. For example, the risk of early onset of age-related dementia is believed to be associated with oxidative
stress. However, the mechanism of oxidative stress-induced changes in physiological factors is not fully understood. Fromstudies performed in “a hypoxic-environment”, much new knowledge and understanding of the effects of oxidative stress isemerging. In this symposium, the researchers behind these studies will present recent findings and new hypothesis
regarding 1) cognitive function 2) respiratory function, peripheral chemoreflex and cardiovascular regulation 3) muscle
characteristic, and 4) cerebral blood flow regulation. Throughout the discussions we hope that new research projects,
methods and corporations will arise with the purpose of developing new countermeasures against the negative healtheffects of oxidative stress. We will formulate a clear rational and recommendations for future studies focusing on the effectsof oxidative stress on cerebral function and dementia as well as cardiovascular diseases.

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Posters Day 3

Aims & Scope第94回⽇本⽣理学会⼤会

公募シンポジウム 22

J 会場  Symposium 22

Hall J

大会第2日：3月29日（水）・March 29（Wed） 8:50 - 10:50

小胞体Ca2+ストア研究の進展

Recent advance in regulation of Ca2+ store in endoplasmic reticulum
オーガナイザー・Organizer：
南沢 享（東京慈恵会医科大学 細胞生理学講座）
Susumu Minamisawa (Dept Cell Physiol, Jikei Univ)

2S22J1-1

疾患変異RyR2はCa2+ 動態をどのように変調するか？−非心筋細胞および心筋由来細胞を用いた検討−○呉林 なごみ
順天堂大・医・薬理How do disease-linked RyR2s modulate Ca2+ dynamics in cultured non-cardiac
and cardiac cells?
Nagomi Kurebayashi
Dept Pharmacol, Fac Med, Juntendo Univ, Tokyo, Japan

2S22J1-2

心筋筋小胞体でのカルシウム再取り込み機構○南沢 享
東京慈恵会医科大学・細胞生理学

Regulation of calcium uptake into the sarcoplasmic reticulum in the heart
Susumu Minamisawa
Dept Cell Physiol, Jikei Univ, Tokyo, Japan

2S22J1-3

小胞体カウンターイオンチャネルTRIC-Bはコラーゲン分泌及び骨ミネラル化を制御する○趙 成珠1，竹島 浩2
1京都大・iPS，2京都大・院薬・生体分子

Endoplasmic reticulum counter-ion channel TRIC-B regulates collagenproduction and bone mineralization
Chengzhu Zhao1, Hiroshi Takeshima2

1CiRA, Kyoto Univ, Kyoto, Japan, 2Dept Bio Chem, Grad Sch Pharm, Kyoto Univ, Kyoto, Japan

2S22J1-4

SR Ca2+-ATPase構造研究における最近の進展○小川 治夫
東大・分生研Recent advances in structural studies of SR Ca2+-ATPase
Haruo Ogawa
IMCB, Univ Tokyo, Tokyo, Japan

Aims & Scope
The endoplasmic reticulum (ER), an extensive intracellular membrane system, integrally regulates the intracellular Ca2+
concentration in various organs. Ryanodine receptor (RyR) ans IP3 receptor plays a primary role in releasing Ca2+ from the
ER. The trimeric intracellular cation (TRIC) channels at the ER membrane support Ca2+ release by mediating cationic flux tomaintain electrical neutrality. Sarco(endo)plasmic reticulun calcium ATPase (SERCA) controls the uptake of Ca2+ into the ER.
The intracellular Ca2+ concentration is also fine-tuned by their intrinsic regulatory domains and associated ER proteins. A
growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling andCa2+-dependent signaling pathways play a critical role in maintaining cellular function. Therefore, impairment of ER
function directly causes diseases in various organs such as the heart, muscles, and bones. In this symposium, we will focus
on the recent advances in knowledge concerning Ca2+ regulation and function of the ER.
Key words: ryanodine receptor, IP3 receptor, sarcoplasmic reticulum, calcium ATPase, phospholamban, sarcolipin, TRIC,
sarcalumenin, heart failure, arrhythmia, malignant hyperthermia, bone mineralization
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Hall D

Lectures

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

日本病態生理学会連携シンポジウム
自律神経研究の新しい流れと病態生理学

Joint Symposium with Japanese Society of Pathophysiology
New studies on autonomic nervous system and pathophysiology
オーガナイザー・Organizer：
和田 圭司（国立精神・神経医療研究センター）
Keiji Wada (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National
Center of Neurology and Psychiatry)
田中 潤也（愛媛大学医学研究科・分子細胞生理学講座）
Junya Tanaka (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University)

2S23D2-1

オプトジェネティクスを用いた自律神経の操作：延髄C1ニューロン刺激による腎虚血再灌流障害の軽減作用を例に○安部 力1,2，井上 剛3，イングリス エム アンドリュース2，ビアル イ ケネス2，
ホアン リイピン3，ジェ ホン3，ダイアン エル ロジン3，ルース エル ストルネッタ2，
オオクサ ディ マーク3，ギエネ ジ パトリシュ 2
1岐阜大学・医・生理学，2バージニア大学，3バージニア大学

Protection of renal ischemia/reperfusion injury by optogenetic stimulation of
the C1 neurons
Chikara Abe1,2, Tsuyoshi Inoue3, Andrews M Inglis2, Kenneth E Viar2,
Li-Ping Huang3, Hong Ye3, Rosin L Diane3, Stornetta L Ruth2, Mark D Okusa3,
Patrice G Guyenet2

1Dept Physiol, Gifu Univ Grad Sch Med, Gifu, Japan, 2Dept Pharmacol, UVA, Charlottesville, VA,
USA, 3Dept Medicine, Div Nephrol, UVA, Charlottesville, VA, USA

2S23D2-2

心臓型アデニル酸シクラーゼの阻害は心機能を低下させることなくカテコラミン誘発性
不整脈を抑制する○吹田 憲治1，藤田 孝之2，奥村 敏1，石川 義弘2

Symposia

D 会場  Symposium 23

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Posters Day 1

公募シンポジウム 23

Inhibition of cardiac adenylyl cyclase suppresses catecholamine-induced
arrhythmias without deteriorating heart function
Kenji Suita1, Takayuki Fujita2, Satoshi Okumura1, Yoshihiro Ishikawa2

1Dept Physiol, Tsurumi Univ, Yokohama, Japan, 2Cardiovascular Research Institute, Yokohama

City Univ, Yokohama, Japan

摂食調節因子による自律神経調節と生理的意義○谷田 守
金沢医大・生理2

Posters Day 3

2S23D2-3

Posters Day 2

1鶴見大・歯・生理学，2横浜市大・院医・循環制御医学

Physiological significance of autonomic regulation by feeding regulators
Mamoru Tanida
Dept Physiol2, Kanazawa Med Univ, Isikawa, Japan

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2S23D2-4

非神経性心臓コリン作動系は迷走神経を介してストレス抵抗性を亢進させる○柿沼 由彦1，及川 誌乃1，甲斐 裕子1，大畠 久幸1，眞野 あすか1，溝口 尚子2，
洲鎌 秀永1，根本 崇宏1，鈴木 健治1，村本 和世2，金田 誠1
1日医大・院医・生体統御科学，2明海大学

歯学部

生理学

Non-neuronal cardiac cholinergic system induces central anti-stress responses

Yoshihiko Kakinuma1, Shino Oikawa1, Yuko Kai1, Hisayuki Ohata1,
Asuka Mano1, Naoko Mizoguchi2, Shuei Sugama1, Takahiro Nemoto1,
Kenji Suzuki1, Kazuyo Muramoto2, Makoto Kaneda11Dept Physiol, Grad Sch Med, Nippon Med Sch, Tokyo, Japan, 2Dept Physiol, Meikai Univ, Saitama,Japan

2S23D2-5

迷走神経共通肝枝と情動行動○関口 正幸
国立精神・神経医療研究センター

The common hepatic branch of the vagal nerve and emotional behaviors
Masayuki Sekiguchi
Dept Degen Neurol Dis, Natl Inst Neurosci, Natl Center Neurol Psychiat, Tokyo, Japan

Aims & Scope
Communication between brain and internal organs is likely to be utilized to maintain homeostasis in the body of animal.
Both afferent and efferent fibers of the autonomic nervous system play pivotal roles in this communication. Here, we
introduce recent advances in the studies about the autonomic nervous system. We also try to show the contribution ofthese advances to pathophysiology. For this purpose, four researchers who are active internationally in this field
respectively present their studies on various autonomic nervous systems in this symposium. It includes the autonomic
control of cardiac functions, brain-gut interaction, the vagus nerve stimulation, and interoceptional control of brain
emotional function by vagal afferents. By these topics, we aim to further stimulate studies on the autonomic nervous
system. This symposium is held under the coordination of the Physiological Society of Japan and Japanese Society of
Pathophysiology.

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The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 24

E 会場  Symposium 24

Hall E

Lectures

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

循環器疾患における神経・炎症・代謝性機序の関わりと重要性

Neurogenic, inflammatory, and metabolic mechanisms of cardiovascular disease

Symposia

オーガナイザー・Organizer：
佐田 悠輔（Baker研究所）
Yusuke Sata (Neurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute)

James Pearson（国立循環器病研究センター研究所 心臓生理機能部）(Department of Cardiac Physiology, National Cerebral and Cardiovascular Center)

2S24E2-1

Sympathetic nervous system mechanisms of cardiovascular disease
Murray D Esler
Baker IDI Heart and Diabetes Institute, Melbourne, Australia

Mechanisms underlying neurogenic hypertension in Schlager mouse

2S24E2-3

Identifying the neural network that triggers sympathetic activation following
acute myocardial infarction
Daryl O Schwenke, Ranjan Roy, Colin H Brown
Dept Physiol, Univ Otago, New Zealand

2S24E2-4肺高血圧症病態におけるInterleukin-6/Interleukin-21シグナル軸の役割○中岡 良和1，稲垣 薫克1，白井 幹康2
1国循研究所・血管生理，2国循研究所・肺高血圧症研究部

The role of interleukin-6/interleukin-21 signaling axis in pulmonary arterial
hypertension
Yoshikazu Nakaoka1, Tadakatsu Inagaki1, Mikiyasu Shirai2

1Dept Vasc Physiol, Natl Cereb Cardiovasc Ctr Res Inst, Suita, Japan, 2Dept Adv Med Res for PH,
Natl Cereb Cardiovasc Ctr Res Inst, Suita, Japan

Aims & Scope
Cardiovascular disease (CVD) is usually accompanied by multiple risk factors but largely preventable with comprehensive
risk assessment and effective management. However, even in the most common CVD, hypertension, only half of patients
have blood pressure under control. Sustained elevation of sympathetic nervous system is a hallmark of hypertension.
Importantly, the neural pathophysiology of hypertension is closely linked with other prevalent CVD risk factors such as
metabolic disease, including obesity and diabetes. Further, perturbed lipid metabolism and atherosclerosis are closely
linked with cardiac and vascular inflammation. Past and recent studies of the symposium invited speakers not only highlightstrong interrelationships between various CVD disease states, but also that sympathetic activation, altered immunity, andmetabolic disorder in particular evoke synergistic interactions that frequently lead to worsening of CVD and heart failure
over time. Multiple underlying factors have now been shown to be critical in the early pathogenesis of various forms ofhypertension that are complicated by obesity, atherosclerosis and diabetes. In this symposium, the world leading scientistsof the relevant fields will discuss the crucial relationship of sympathetic, immune, and metabolic mechanisms underlying
increasingly prevalent CVD.

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Posters Day 1

Baker IDI Heart and Diabetes Institute, Melbourne, Australia

Posters Day 2

Geoffrey A Head

Posters Day 3

2S24E2-2

第94回⽇本⽣理学会⼤会

公募シンポジウム 25

F 会場  Symposium 25

Hall F

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

生理学研究を深化させる新しい光学技術

New optical technology deepening the physiological research
オーガナイザー・Organizer：
守本 祐司（防衛医科大学校 分子生体制御学講座）
Yuji Morimoto (Dept Integrative Physiol & Bio-Nano Med, NDMC)

2S25F2-1

マルチスペクトルイメージング機構を備えた蛍光内視鏡と5-アミノレブリン酸を用いた
アテローム性プラークの検知技術○守本 祐司1，萩沢 康介2
1防衛医大・分子生体制御，2防衛医大・生理

Visualizing method of the atheromatous plaque pre-administered 5aminolevulinic acid using a fluorescent endoscope equipped with multispectral
imaging system
Yuji Morimoto1, Kohsuke Hagisawa2

1Dept Integrative Physiol & Bio-Nano Med, NDMC, Tokorozawa, Japan, 2Dept Physiol, NDMC,

Tokorozawa, Japan

2S25F2-2波長1000nmを超える近赤外波長域の新しいイメージング技術の開発○池原 譲1,2
1産総研・創薬基盤，2産総研・電子光技術

Development of a new near infrared imaging technology over 1000nm wave
lengthYuzuru Ikehara1,2

1Biotech Res Inst for Drug Discovery, AIST, Japan, 2Electronics and Phot Res Inst, AIST, Japan

2S25F2-3ラマン散乱を利用した細胞分子イメージング○藤田 克昌阪大・院工・応物

Raman microscopy for molecular imaging of living cells
Katsumasa Fujita
Dept Appl Phys, Osaka Univ, Osaka, Japan

2S25F2-4

遺伝子発現動態の光操作から明らかになる神経幹細胞の制御機構○今吉 格
京大・院・生命

Regulatory mechanism of neural stem cells revealed by optical manipulation ofgene expressions
Itaru Imayoshi
Grad Sch Biostudies, Kyoto Univ, Kyoto, Japan

Aims & Scope
It goes without saying the importance of observing living bodies in real-time in the physiological research field. To achieve
such observation, optical technology is very useful. Optical technology enables us to watch nano-scale structures, visualize
lesions without contrast agents, and clarify biological functions by the use of optogenetic methods, corresponding to thediscovery of unknown biological phenomenon and deepening physiology.
In this symposium, spotting on the new optical engineering technique that can be used in physiology research, leading
researchers will present their latest technological accomplishment. This topic greatly contributes to the life science andprofoundly encourages the young members of this society.
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公募シンポジウム 26

I 会場  Symposium 26

Hall I

Lectures

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

網膜内層における情報処理研究の最前線

Frontier of signal processing research in the inner layer of the retina

Symposia

オーガナイザー・Organizer：
金田 誠（日本医科大学大学院 感覚情報科学分野）
Makoto Kaneda (Dept Physiol, Nippon Med Sch)宮地 栄一（藤田保健衛生大学医学部 生理学）
Ei-ichi Miyachi (Department of Physiology, Fujita Health University School of Medicine)

2S26I2-1

水平細胞は網膜神経回路において多様な機能を有する○古川 貴久1，茶屋 太郎1，松本 彰弘2，杉田 祐子1，桒原 隆亮3，立花 政夫2
1大阪大・蛋白研，2東京大・人文社会系・心理学，3大阪大・超高圧電顕センター

Horizontal cells play versatile functional roles in the retinal circuit

Takahisa Furukawa1, Taro Chaya1, Akihiro Matsumoto2, Yuko Sugita1,
Ryusuke Kuwahara3, Masao Tachibana2
1Inst Protein Res, Osaka Univ, 2Dept Psychol, Grad Sch Humanities and Sciol, Univ Tokyo, 3Res
Center Ultrahigh Voltage Electron Microscopy, Osaka Univ

2S26I2-2

Congenital nystagmus gene FRMD7 Is necessary for establishing a neuronal
circuit asymmetry for direction selectivity

教
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Keisuke Yonehara

2S26I2-3

メラノプシンの光応答モデル構築にむけて○松山オジョス 武1，高橋 政代1，七田 芳則2
1理研・CDB・網膜再生，2京大・理学・生物物理・七田研

A new model for Melanopsin based photoresponses

Take Matsuyama1, Masayo Takahashi1, Yoshinori Shichida2
1RIKEN CDB, Retinal Regeneration Lab, Kobe, Japan, 2Kyoto Univ, Grad Sch Sci, Biophys, Japan

代謝型グルタミン酸受容体6型の極性輸送・膜発現に関わる分子機構の解析

Posters Day 2

2S26I2-4○赤木 巧，レイ ディリップ，木山 裕子，荻原 郁男，金田 誠
日本医科大学・システム生理学

Analysis of molecular mechanisms controlling the polarized targeting of
metabotropic glutamate receptor type 6
Takumi Akagi, Rai Dilip, Yuko Kiyama, Ikuo Ogiwara, Makoto Kaneda
Dept Physiol, Nippon Med Sch, Tokyo, Japan

広域画像の揺動下における網膜神経節細胞の非線型な受容野特性

Posters Day 3

2S26I2-5

Posters Day 1DANDRITE, Aarhus University, Denmark○松本 彰弘1，立花 政夫1,2
1東京大・院人社・心理，2立命館大・総合科学研究機構

Nonlinear modulation of receptive field properties of retinal ganglion cells
during global motion
Akihiro Matsumoto1, Masao Tachibana1,21Dept Psychol, Grad Sch Hum and Soc, Univ Tokyo, Tokyo, Japan, 2Center for System Vision

Science, Organization of Science and Technology, Ritsumeikan Univ, Shiga, Japan

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2S26I2-6

P2X受容体を介したコリン取り込み機構○金田 誠1，石井 俊行1，本間 耕平1，眞野 あすか1，重松 康秀2，井上 浩義3，柿沼 由彦1
1日医大・システム生理，2東京女子医大・東医療センター，3慶応大・医・化学

P2X-purinoceptor-mediated choline uptake

Makoto Kaneda1, Toshiyuki Ishii1, Kohei Homma1, Asuka Mano1,
Yasuhide Shigematsu2, Hiroyoshi Inoue3, Yoshihiko Kakinuma11Dept Physiol, Nippon Med Sch, Tokyo, Japan, 2Tokyo Women's Med Univ, Medical Center, East

Health Center, Tokyo, Japan, 3Dept Chem, Keio Univ Sch Med, Tokyo, Japan

Aims & Scope
Recent progress of the retinal research at the molecular level has shown that retinal neurons (horizontal cells, bipolar cells,
amacrine cells, and ganglion cells) are not homogenous population. They are subdivided into many subtypes on the basisof the differences of their histological architectures. The increasing evidences of the functional study for the individual
subtypes lead many researchers to think that the signal pathways of an individual subtype are used to process the different
properties of the vision in parallel. In this symposium, we will introduce how the subtype-specific signal processing pathway
is formed from the molecular and ionic basis. We will also introduce how the individual subtype contributes the signal
processing in the retina.

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The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 27

J 会場  Symposium 27

Hall J

Lectures

大会第2日：3月29日（水）・March 29（Wed） 13:30 - 15:30

痛みの感覚・情動を司る脳領域における慢性疼痛機序

The mechanisms of chronic pain in the brain areas related to sensory andemotional aspects of pain

Symposia

オーガナイザー・Organizer：
江藤 圭（生理学研究所 生体恒常性発達研究部門）
Kei Eto (Div Homeostatic Development, Natl Inst Physiol Sci)
古賀 浩平（弘前大学大学院医学研究科 脳神経生理学講座）
Kohei Koga (Dept Neurophysiol, Grad Scho Med, Hirosaki Univ)

2S27J2-1

一次体性感覚野の機能的変容による領域間調節機構の慢性疼痛への寄与○江藤 圭1，石川 達也1,2，石橋 仁1,3，鍋倉 淳一11生理研・生体恒常，2福井大・医・脳形態機能学，3北里大・医療衛生・生理

Kei Eto1, Tatsuya Ishikawa1,2, Hitoshi Ishibashi1,3, Junichi Nabekura1

1Div Homeostatic Development, Natl Inst Physiol Sci, Okazaki, Japan, 2Div Brain Struct and Func,
Sch Med, Univ Fukui, Fukui, Japan, 3Dept Physiol, Sch Allied Health Sci, Kitasato Univ,
Sagamihara, Japan

2S27J2-2

慢性疼痛が引き起こす前帯状回シナプス前長期増強の分子機構○古賀 浩平弘前大・院医・脳神経生理

Mechanisms of chronic pain induced presynaptic long-term potentiation in theanterior cingulate cortex
Kohei Koga
Dept Neurophysiol, Grad Scho Med, Hirosaki Univ, Aomori, Japan

2S27J2-3体性感覚皮質dysgranular領域が痛覚情報を表現する

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Posters Day 1

Contribution of inter-regional regulation of primary somatosensory cortical
functional change in chronic pain

Posters Day 2○尾崎 弘展，植田 禎史，宮田 麻理子
東京女子医大・医・生理

The dysgranular area of somatosensory cortex represents nociceptive
information
Hironobu Osaki, Yoshifumi Ueta, Mariko Miyata
Dept Physiol I (Neurophysiol), Sch Med, Tokyo Women's Medical Univ, Tokyo, Japan

侵害受容と痛み情動-痛みの慢性化における扁桃体の役割○高橋 由香里，杉本 真理子，宮沢 祐太，杉村 弥恵，篠原 恵，渡部 文子，加藤 総夫
慈恵医大・総合医科研・神経科学

Posters Day 3

2S27J2-4

From nociception to emotion and vice versa - Roles of the amygdala in pain
chronification
Yukari Takahashi, Mariko Sugimoto, Yuta Miyazawa, Yae K Sugimura,
Kei Shinohara, Ayako M Watabe, Fusao Kato
Dept Neurosci, Center for Neurosci of Pain, Jikei Univ Sch Med, Tokyo, Japan

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Aims & Scope
Pain is a complex experience with sensory and emotional aspects, and each aspect is conveyed via individual pathways. The
thalamus and primary somatosensory cortex (S1 have roles in the sensory aspects of pain, such as the location and durationof pain (sensory center), while the anterior cingulate cortex (ACC) and amygdala are central regions processing theemotional information of pain, such as recognition of the unpleasantness of pain (emotional center). Recent studies using
functional magnetic resonance imaging (fMRI) have demonstrated that activities in these areas alter under the chronic pain
conditions in humans and animal models, suggesting that plastic changes of neuronal function in these areas have criticalroles in chronic pain. However, it still remains unknown how these plastic changes relate to chronic pain. In this symposium,
speakers will talk of this issue in the ACC, amygdala, thalamus and S1 by using multiple advanced techniques including invivo two-photon imaging and we would like to discuss the future direction of pain research.

134

The 94th Annual Meeting of the Physiological Society of JapanC 会場  Symposium 28

公募シンポジウム 28

Hall C

Lectures

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50【新学術「温度生物学」共催】

温度生物学の視点から探る生理機能【Co-sponsored by the MEXT “Thermal biology”】

Physiological functions in thermal biology

Symposia

オーガナイザー・Organizer：
柴崎 貢志（群馬大学大学院医学系研究科 分子細胞生物学）
Koji Shibasaki (Dept Mol Cell Neurobiol, Gunma Univ Grad Sch Med)
岡部 弘基（東京大学大学院薬学系研究科 生体分析化学）
Kohki Okabe (Dept Bioanalytical Chem, Grad Sch Pharmac, Univ Tokyo)

2S28C3-1

脳内温度による神経活動の向上；温度センサー TRPV4の重要性○柴崎 貢志群馬大院・医・分子細胞

Enhancement of neuronal excitability by brain temperature and TRPV4

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Koji Shibasaki
Dept Mol Cell Neurobiol, Gunma Univ Grad Sch Med, Maebashi, Japan

2S28C3-2

電位依存性プロトンチャネルの温度感受性ゲーティング○藤原 祐一郎

Dept Physiol, Grad Sch Med, Osaka Univ, Suita, Japan

2S28C3-3

細胞内局所発熱による細胞機能発現○岡部 弘基1,2
1東大・院薬・分析，2JST さきがけ

Investigation on cell functions mediated by intracellular local thermogenesis
Kohki Okabe1,2

1Dept Bioanalytical Chem, Grad Sch Pharmac, Univ Tokyo, Tokyo, Japan, 2PRESTO, JST, Tokyo,

Japan

2S28C3-4

Functional interaction between thermosensitive TRPV4 and TMEM16A/
anoctamin 1 contributes to stimulated saliva and tear secretion

Sandra Derouiche1, Yasunori Takayama1, Masataka Murakami2, Makoto Tominaga1
1Div Cell Signal, NIPS, Okazaki, Japan, 2NIPS, Okazaki, Japan

Aims & Scope
Temperature affects various physiological functions and is one of the most important factors in homeostasis. Furthermore,temperature powerfully affects every biological process. Humans and many other mammals maintain their internal
temperature as a stable level around 37°C, which appears to be optimal for their functioning as we reported. Recently, wedemonstrated the first intracellular temperature mapping based on a fluorescent polymeric thermometer and fluorescence
lifetime imaging microscopy. Nuclei and mitochondria showed significantly higher temperature than the cytoplasm. These
results showed that our new intracellular thermometry could determine an intrinsic relationship between the temperatureand organelle function. In this symposium, we invited the excellent speakers about the interaction between physiological
functions of ion channels and temperature or measurement of intracellular temperature dynamics. We will introduce our
new and valuable topics related to temperature and physiological functions, and would like to discuss the importance withaudience. We invited an organizer from the biophysical society and a foreign speaker, and would like to have a diverse
symposium focusing on the heterogeneity of the audience.
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Posters Day 2

Yuichiro Fujiwara

Posters Day 3

Temperature-sensitive gating of voltage-gated H+ channels

Posters Day 1

阪大・院医・生理第94回⽇本⽣理学会⼤会

公募シンポジウム 29

D会場  Symposium 29

Hall D

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50

グルタミン酸シナプスの分子・細胞神経生物学

Molecular and cellular neurobiology of glutamatergic synapse
オーガナイザー・Organizer：
神谷 温之（北海道大学大学院医学研究科 神経生物学分野）
Haruyuki Kamiya (Dept Neurobiol, Grad Sch Med, Hokkaido Univ)

2S29D3-1

哺乳類中枢シナプス終末における単一シナプス小胞のライブイメージング○緑川 光春同志社大・脳科学

Live cell imaging of single synaptic vesicles at mammalian CNS presynaptic
terminals
Mitsuharu Midorikawa
Grad Sch Brain Sci, Doshisha Univ, Kyoto, Japan

2S29D3-2表面グルタミン酸受容体発現の長期増強の単一シナプスイメージング○石井 雄一郎，奥野 浩行，藤井 哉，尾藤 晴彦
東大・院医・神経生化

Imaging long-term potentiation of surface glutamate receptors at single
synapsesYuichiro Ishii, Hiroyuki Okuno, Hajime Fujii, Haruhiko Bito
Dept Neurochem, Grad Sch Med, Univ Tokyo, Japan

2S29D3-3

Presynaptic terminal morphology, calcium signaling and short-term plasticity at
hippocampal mossy fiber synapses
Sandrine Pouvreau1, Severine Deforges1, Fabrice P Cordelieres2,
Christophe Mulle1

1IINS, UMR 5297 Univ Bordeaux-CNRS, 33077 Bordeaux, France, 2BIC, UMS 3420 CNRS-UB-US4
INSERM, 33000 Bordeaux, France

2S29D3-4

海馬における軸索スパイクのアナログ制御○大浦 峻介，神谷 温之
北海道大・院医・神経生物

Analog modulation of axonal spikes in the hippocampus
Shunsuke Ohura, Haruyuki Kamiya
Dept Neurobiol, Grad Sch Med, Hokkaido Univ, Sapporo, Japan

Aims & Scope
Glutamatergic synapse plays central roles in excitatory transmission in the central nervous system (CNS). This symposium
will focus on recent progress in the studies on the vaious cellular and molecular aspects of glutamatergic synapses. High
resolution spatiotemporal dynamics of synaptic vesicles within the glutamatergic presynaptic terminals will bedemonstrated using total internal reflection fluorescence (TIRF) microscopy at resolution of single synaptic vesicles. Novel
molecular tools for visualizing postsynaptic glutamate receptor dynamics within the dendritic spines and their application
for the studies of synaptic plasticity will be reported. Roles of mitochondria as a low affinity buffer for Ca2+ handling in thepresynaptic terminals will be also discussed. Temporal modulation of the size of action potentials at the axon terminals willbe also reported using direct electrophysiological recording from the hippocampal mossy fiber axons, a representative en
passant axons with multiple glutamatergic presynaptic terminals. All the findings of these studies aim to illustrate in moredetail of real-time dynamics of the molecular and cellular machinery of glutamatergic synapses. These attempts to update
the biological views of key elements of neuronal signaling in the CNS, i.e. glutamatergic synapses, may help forcomprehensive understanding of the brain functions and their disorders.
136The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 30

F 会場  Symposium 30

Hall F

Lectures

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50

日本循環制御医学会連携シンポジウム
心臓の恒常性を制御するメカニズムとその破綻による病気の発症

Symposia

Joint Symposium with Japan Society of Circulation Control in Medicine
Cardiac regulatory mechanisms to preserve the homeostasis in the heart andinduction of heart disease caused by their disruptions
オーガナイザー・Organizer：
奥村 敏（鶴見大学歯学部 生理学講座）
Satoshi Okumura (Dept Physiol, Tsurumi Univ Yokohama)
藤田 孝之（横浜市立大学医学部 循環制御医学）
Takayuki Fujita (Cardiovasc Res Inst, Grad Sch Med, Yokohama City Univ)

圧負荷誘導心不全におけるDrp1依存性ミトコンドリアオートファジーの役割○白壁 章宏1，池田 義之2，齊藤 寿郎2，ペヨン ザイ2，畑 典武1，浅井 邦也3，
清水 渉3，佐渡島 純一2
1日本医科大学千葉北総病院・集中，2ラトガーズ大学・細胞生物学部門，3日本医科大学付属病院・循環器内科学

Drp1-dependent mitochondrial autophagy plays a protective role againstpressure-overload-induced mitochondrial dysfunction and heart failure
Akihiro Shirakabe1, Yoshiyuki Ikeda2, Toshiro Saito2, Zai Peiyong2,
Noritake Hata1, Kuniya Asai3, Wataru Shimizu3, Jyunichi Sadoshima2

1Nippon Med Sch Chiba Hokusoh Hospital, Div Intensive Care Unit, Chiba, Japan, 2Dept Cell Biol
Mol Med, Rutgers New Jersey Medical School, Newark, New Jersey, USA, 3Dept Cardiovasc
Medicine, Nippon Med Sch, Tokyo, Japan

2S30F3-2心筋細胞の生存維持におけるTCTPの役割○藤田 孝之，蔡 文倩，日高 祐子，金 慧玲，プラジャパティ ラジェッシュ，梁 宸，
中村 隆，石川 義弘
横浜市大・医・循環制御医学

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Posters Day 1

2S30F3-1

Posters Day 2

TCTP plays an important role in the survival of cardiac myocytes
Takayuki Fujita, Wenqian Cai, Yuko Hidaka, Huiling Jin, Rajesh Prajapati,
Chen Liang, Takashi Nakamura, Yoshihiro Ishikawa
Cardiovasc Res Inst, Grad Sch Med, Yokohama City Univ, Yokohama, Japan

2S30F3-3

心疾患発症過程におけるEpac1の役割○奥村 敏
鶴見大学・歯・生理The role of Epac1 for the development of heart failure

Posters Day 3

Satoshi Okumura
Dept Physiol, Tsurumi Univ Yokohama, Japan

2S30F3-4

交感神経系と副交感神経系による適切な心拍数調節のメカニズム○川田 徹，杉町 勝
国循・循環動態

Mechanisms of proper heart rate control by the sympathetic andparasympathetic systems
Toru Kawada, Masaru Sugimachi
Dept Cardiovasc Dynamics, Natl Cereb Cardiovasc Center, Suita, Japan

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Aims & Scope
The heart maintains the quality of the intracellular environment in response to various stimuli including mechanical,
metabolic, and neuro/hormonal, aging stresses, which might be mediated through the signaling such as autonomic
nervous system, hypertrophy, apoptosis and autophagy in the heart. However, inappropriate activation or termination ofthese signaling has been demonstrated to decrease the quality of the intracellular environment and disrupt the
homeostasis in the heart. More importantly, they might cause heart disease such as heart failure and arrhythmia. Thissymposium invites four active cardiologists about the field of autonomic nervous system, myocyte apoptosis, andautophagy-lysosome system in the heart. We asked them to review their interested regulatory mechanisms to preserve thehomogeneity in the heart and how these signaling might cause heart disease with their newly identified findings in theheart.

138

The 94th Annual Meeting of the Physiological Society of Japan

公募シンポジウム 31

J 会場  Symposium 31

Hall J

Lectures

大会第2日：3月29日（水）・March 29（Wed） 16:50 - 18:50

味覚と嗅覚におけるモードスイッチングメカニズム

Mode-switching mechanisms of gustatory and olfactory sensations
オーガナイザー・Organizer：
荒田 晶子（兵庫医科大学生理学 生体機能部門）
Akiko Arata (Department of Physiology, Hyogo College of Medicine)

2S31J3-1

Symposia

政岡 ゆり（昭和大学医学部 生体調節機能学）
Yuri Masaoka (Dept Physiol, Hyogo Coll Med)

扁桃体中心核セロトニン2A受容体による先天的と後天的な恐怖の階層性制御○山中（伊早坂）智子，松尾 朋彦，小早川 令子，小早川 高
関西医大・附属生命・神経機能

Htr2a-expressing cells in the central amygdala control the hierarchy between
olfactory-mediate innate and learned fear
Tomoko Isosaka-Yamanaka, Tomohiko Matsuo, Reiko Kobayakawa,
Ko Kobayakawa
Dept Functional Neurosci, Kansai Med Univ, Osaka, Japan

2S31J3-2

ヒトにおける味覚、嗅覚、視覚の多感覚相互作用：心理・生理学的研究○岡本 雅子1,2
1東大・院農・生命科学，2ERATO東原化学感覚プロジェクト

Interaction between taste, smell and visual information: human psychologicaland physiological studies
Masako Okamoto1,2

1Grad Sch Agric Life Sci, Univ, Tokyo, Japan, 2ERATO Touhara Chemosensory Signal Project

2S31J3-3

嗅覚、情動、呼吸リズム○政岡 ゆり昭和大・医・生体調節機能学

Respiration is for live, and for olfaction and emotions

Posters Day 2

Yuri Masaoka
Dept Physiol, Showa Uni Sch Med, Tokyo, Japan

2S31J3-4

Posters Day 1

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周産期における下位脳幹部の味覚神経回路の発達モードの変換点○荒田 晶子，中山 栗太，吉田 千晃
兵庫医科大学・生理・生体機能

The turning points of taste sensation during perinatal development
Akiko Arata, Kurita Nakayama, Chiaki Yoshida

Aims & Scope
Feeding behavior is much influenced by an interaction between gustatory and olfactory sensations. Various switchingmechanism underlying this taste and smell integration are important to understand the rewarding system, cognitive andemotional influences, decision making and social interaction in animals and humans. We would like to propose this
symposium to highlight a new insight of this integration from micro to macro views. This symposium is comprised of four
presenters; Dr. Isosaka-Yamanaka will talk about a mode-switching mechanism between olfactory-mediate innate fear andlearned fear, Dr. Okamoto will talk about the interaction between taste and smell perception influenced by an extrinsic
information, Dr. Masaoka will talk about themode-switching mechanism between respiration change and olfaction, and I
will talk about the turning points of taste sensation during development. We also aim to organize this symposium bymembers of woman scientists who dedicated their passions to their research works.
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Posters Day 3

Dept Physiol, Hyogo Coll Med, Nishinomiya, Hyogo, Japan

第94回⽇本⽣理学会⼤会

公募シンポジウム 32

A会場  Symposium 32

Hall A

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50【新学術「リポクオリティ」共催】
膜タンパク質̶脂質相互作用への新たな挑戦：
リポクオリティーによる膜タンパク質機能の制御【Co-sponsored by the MEXT “Lipoquality”】
Lipoquality and functions of membrane proteins
オーガナイザー・Organizer：
岡村 康司（大阪大学大学院 医学系研究科）
Yasushi Okamura (Dept Physiol, Grad Sch Med, Osaka Univ)
有田 誠（理化学研究所 統合生命医科学研究センター）
Makoto Arita (RIKEN IMS)

3S32A1-1脂肪酸クオリティの最先端リピドミクスと生理的意義の解明○有田 誠1,2,3
1理研・IMS・メタボローム，2慶應大・薬・代謝生理化学，3横市大・院生命医

Advanced lipidomics to understand the quality difference of fatty acids inbiological systems
Makoto Arita1,2,3

1RIKEN-IMS, Yokohama, Japan, 2Keio Univ Faculty of Pharmacy, Tokyo, Japan, 3Grad Sch Med

Life Sci, Yokohama City Univ, Yokohama, Japan

3S32A1-2

電位依存性ホスファターゼの構造生物学的研究○中川 敦史1，成田 宏隆1，神田 直樹1，川鍋 陽2，岡村 康司2
1阪大・蛋白研，2阪大・院医・統合生理

Structural studies of voltage-sensing phosphatase

Atsushi Nakagawa1, Hirotaka Narita1, Naoki Kanda1, Akira Kawanabe2,
Yasushi Okamura2
1Inst Protein Res, Osaka Univ, Japan, 2Dept Physiol, Grad Sch Med, Osaka Univ, Suita, Japan

3S32A1-3

電位依存性イオンチャネルの電位センサードメインへのリガンド結合による機能制御の構造メカニズム○大澤 匡範慶應義塾大・薬・生命機能物理学

Structural mechanism of functional regulation of the voltage-gated ion channels
by ligand binding to voltage-sensing domain
Masanori Osawa
Div Physics for Life Functions, Facl Pharmacy, Keio Univ, Japan

3S32A1-4

The molecular mechanism of polyunsaturated fatty acids opening voltage-gated
K channels
Fredrik Elinder
Dept Clin Exp Med, Linkoping Univ, Linkoping, Sweden

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The 94th Annual Meeting of the Physiological Society of Japan

3S32A1-5

電位依存性ホスファターゼにおける膜相互作用の動態と役割○岡村 康司1，川鍋 陽1，西澤 和久2，中川 敦史3，成田 宏隆3，坂田 宗平4，神野 有香1Mechanisms and roles of lipid interaction in voltage-sensing phosphatase
Yasushi Okamura1, Akira Kawanabe1, Kazuhisa Nishizawa2,
Atsushi Nakagawa3, Hirotaka Narita3, Souhei Sakata4, Yuka Jinno1

1Dept Physiol, Grad Sch Med, Osaka Univ, Suita, Japan, 2Dept Clinical Lab Sci, Teikyo Univ Sch
Medical Technol, Tokyo, Japan, 3Inst Protein Res, Osaka Univ, Suita, Japan, 4Dept Physiol, Med,
Osaka Medical College, Takatsuki, Japan

Aims & Scope

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Posters Day 3

Posters Day 2

Posters Day 1

Lipids are essential components of biological membranes and regulate ion channels and receptors through forming
environments and by direct association. Lipids also serve as important mediators of cell signaling in many biological or
pathological events such as inflammation and synaptic plasticity. Recent progress of cryoelectron-microscopy and X-ray
crystal structure analysis of ion channels has shown several examples where lipids are parts of complexes of membraneproteins serving as key substances for regulating protein functions, not just providing environment or supporting
membrane proteins. In addition, recent progress of mass spectrometry has identified surprisingly large number of lipid
molecules with diversities in the length of carbon chain of acyl-group. Understanding structural and chemical basis bywhich membrane proteins recognize such specific molecular details (so called “lipoquality”) for their functions is emerging
to be important. In this symposium, we will have four speakers from cutting edge research of lipids and membrane proteins
and will explore for future directions of “lipoquality”-based understandings of life.

Symposia

大・医・生理Lectures

1 大阪大・院医・統合生理，2 帝京大・医療技術・臨床検査，3 大阪大・蛋白研・超分子構造解析，4 大阪医141

第94回⽇本⽣理学会⼤会

公募シンポジウム 33

F 会場  Symposium 33

Hall F

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

神経科学から読み解く脳卒中リハビリテーションの作用：損傷脳はどう再編成されるか

Exploring the effects of poststroke rehabilitation on the reorganization of
the injured brain from a viewpoint of neuroscience
オーガナイザー・Organizer：
石田 章真（名古屋市立大学大学院医学研究科 脳神経生理学分野）
Akimasa Ishida (Dept Neurophysiol and Brain Sci, Nagoya City Univ Grad Sch Med Sci)
田尻 直輝（吉備国際大学大学院 心理学研究科）
Naoki Tajiri (Dept Psychol, Grad Sch Psychol, Kibi Inter Univ)

3S33F1-1

脳梗塞後の課題特異型訓練によるニューラルネットワークリモデリング○岡部 直彦，氷見 直之，丸山 恵美，成田 和彦，宮本 修
川崎医科大学・生理学2

Neural network remodeling induced by task-specific rehabilitative training after
strokeNaohiko Okabe, Naoyuki Himi, Emi Maruyama, Kazuhiko Narita,
Osamu Miyamoto
2nd Dept Physiol, Kawasaki Med Sch

3S33F1-2

脳血管障害後の集中リハビリテーションによる皮質-脳幹路の再編○石田 章真1，小林 憲太2，伊佐 正3，飛田 秀樹11名古屋市大・院医・脳神経生理，2生理研・ウイルスベクター開発室，3京都大・院医・神経生物

Rehabilitation-induced reorganization of the cortico-brainstem circuits after
strokeAkimasa Ishida1, Kenta Kobayashi2, Tadashi Isa3, Hideki Hida1

1Dept Neurophysiol and Brain Sci, Nagoya City Univ Grad Sch Med Sci, Nagoya, Japan, 2Sec Viral

Vector Dev, NIPS, Okazaki, Japan, 3Dept Physiol and Neurobiol, Kyoto Grad Sch Med, Kyoto, Japan

3S33F1-3

サル脳損傷モデルを用いたリハビリトレーニングによる把握動作の変化と神経の可塑的変化の解析○村田 弓，肥後 範行
産総研・人間情報

Training-induced recovery of grasping and underlying neuronal plasticity after alesion in macaque brain
Yumi Murata, Noriyuki Higo
Hum Informat Res Inst, AIST, Tsukuba, Japan

3S33F1-4

基礎研究から臨床応用へ向けてー脳疾患に対するリハビリテーションの展望ー○田尻 直輝1,2，安原 隆雄2，亀田 雅博2，守本 純2，岡崎 三保子2，金 恭平2，馬越 通有2，
金 一徹2，桑原 研2，上利 崇2，金子 裕次3，ボーロンガン ブイ シーザー 3，伊達 勲2
1吉備国大・院心・心理，2岡山大・院医・脳外科，3南フロリダ大・医・脳外科

CNS disorders : lab-to-clinic translational research

Naoki Tajiri1,2, Takao Yasuhara2, Masahiro Kameda2, Jun Morimoto2,
Mihoko Okazaki2, Kyohei Kin2, Michiari Umakoshi2, Ittestsu Kin2,
Ken Kuwahara2, Takashi Agari2, Yuji Kaneko3, Cesar V Borlongan3, Isao Date2
1Dept Psychol, Grad Sch Psychol, Kibi Inter Univ, Okayama, JAPAN, 2Dept Neurol Surg, Okayama

Univ Grad Sch Med, Okayama, JAPAN, 3Dept Neurol Surg, Univ South Florida Med, FL, USA

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Symposia

Poststroke rehabilitation is known as an important method to promote functional recovery. However, the detailed and basic
mechanism of the effects of rehabilitative therapy on the injured brain is still unclear. The aim of the present symposium is
to share the recent evidences presented by up-and-coming researchers about the factors involving rehabilitation. Various
remarkable topics will be introduced; such as the rehabilitation-induced reorganization of the injured brain, the influence ofthedifferences of the type of stroke on rehabilitation and the combination with the regenerative therapy. The symposium
can help understanding of the physiological effects of poststroke rehabilitation and stimulating the discussion.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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公募シンポジウム 34

H会場  Symposium 34

Hall H

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

ペリサイトの多様な機能と表現型 −基礎研究からベッドサイドへの展開−

The diverse functions and phenotypes of pericytes – from bench to bedside –オーガナイザー・Organizer：
橋谷 光（名古屋市立大学医学研究科 細胞生理学分野）
Hikaru Hashitani (Dept Cell Physiol, Grad Sch Med, Nagoya City Univ)

Theodor Burdyga（リバプール大学）(Dept Physiol, Univ, Liverpool)

3S34H1-1

Live imaging of ureteric microvascular networks in situ: topology, morphology,
Ca2+ signalling and vasomotor responses of myocytes and pericytes
Theodor Burdyga
Dept Physiol, Univ, Liverpool, UK

3S34H1-2

脳血管障害におけるペリサイトの役割と意義○吾郷 哲朗
九大・院医・病態機能内科学

Role and significance of pericyte in cerebrovascular diseases
Tetsuro Ago
Dept Med Clin Sci, Grad Sch Med Sci, Kyushu Univ, Fukuoka, Japan

3S34H1-3周皮細胞による血管新生の促進○森川 俊一東京女子医大・解剖発生

Promotion of angiogenesis by pericytes
Shunichi Morikawa
Dept Anat Dev Biol, Tokyo Women's Med Univ, Tokyo, Japan

3S34H1-4

内臓微小血管の各ユニットにおけるペリサイトの機能的連携○橋谷 光
名古屋市立大学・院医・細胞生理

Functional coupling of pericytes in different units of visceral microvasculature
Hikaru Hashitani
Dept Cell Physiol, Grad Sch Med, Nagoya City Univ, Nagoya, Japan

Aims & Scope
Pericytes were originally described as perivascular cells wrapping around capillaries but also distributed in pre-capillaryarterioles and post-capillary venules. These cells can be identified by their expression of PDGFRβ and NG2, but may also
express α-smooth muscle actin. Consistently, pericytes themselves sometimes appear contractile even sending electricalsignals to their upstream or downstream microvasculature to regulate their contractility. In several vascular beds, pericytes
develop spontaneous electrical or Ca2+ signals, and thus may function as pacemaker cells driving neighbouring mural cells.
Pericytes make close appositions with the endothelium, and pericyte-endothelium interactions are implicated in regulating
the blood flow in the microvasculature. Pericytes also have important roles in angiogenesis, maintenance of the vascularpermeability, and may act as multipotent stem and/or progenitor cells. During angiogenesis associated with wound healing
as well as tumor growth, pericytes undergo phenotypic changes. Altered function and morphology of pericytes play a
critical role in pathological conditions such as diabetic retinopathy or cerebral stroke, in which upregulation of signalling
pathways in pericytes may be casually related with the enhanced blood-brain barrier breakdown. Recent advances in theunderstanding of the diverse functions of pericytes as well as their phenotype changes in disease will be reviewed.

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公募シンポジウム 35

I 会場  Symposium 35

Hall I

Lectures

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

心臓のメカニクスとエナジェティクス

Cardiac mechanics and energetics
オーガナイザー・Organizer：
杉町 勝（国立循環器病研究センター 循環動態制御部）
Masaru Sugimachi (Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center)

3S35I1-1

Symposia

清水 秀二（国立循環器病研究センター 循環動態制御部）
Shuji Shimizu (Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center)

脊椎動物の心臓進化：冠循環の血流特性と心臓メカニクスからの推測○毛利 聡，花島 章，氏原 嘉洋，橋本 謙
川崎医科大学・生理学1

Evolution of vertebrate heart: Inference based on the relation between
coronary circulation and ventricular mechanics
Satoshi Mohri, Akira Hanashima, Yoshihiro Ujihara, Ken Hashimoto
First Dept Physiol, Kawasaki Med Sch, Kurashiki, Japan

3S35I1-2

ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用○ピアソン ジェームズ1,2，土持 裕胤1，八木 直人3，白井 幹康1
1国循・心臓生理，2モナシュ大・生理，3高輝度光科学研究センター

Modulation of cardiac sarcomeric function by rho-kinase and oxidative stress

教
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Monash University, Melbourne, Australia, 3JASRI, Harima, Japan

3S35I1-3

新しいテクノロジーによる左室メカノエナジェティクス解析の試み○小畑 孝二1，安部 力1，森田 啓之1，高木 都1,2
1岐阜大院・医・生理，2奈良県立医科大学医学部

Challenges of cardiac mechanoenergetics analysis with new technology
Koji Obata1, Chikara Abe1, Hironobu Morita1, Miyako Takaki1,2

1Dept Physiol, Gifu Univ, Grad Sch Med, Gifu, Japan, 2Nara Med Univ, Kashihara, Japan

3S35I1-4

心筋酸素消費最小化に着目した心筋梗塞治療○朔 啓太，砂川 賢二
九州大学・循環器病研究センター

Minimizing myocardial oxygen consumption by left ventricular assist device
limits the infract size and prevents the worsening of subsequent heart failure in
myocardial infarction

Posters Day 2

1Dept Cardiac Physiol, National Cerebral and Cardiovascular Center, Osaka, Japan, 2Dept Physiol,

Posters Day 1

James T Pearson1,2, Hirotsugu Tsuchimochi1, Naoto Yagi3, Mikiyasu Shirai1

Ctr Disruptive Cardiovasc Med, Kyushu Univ, Fukuoka, Japan

Aims & Scope
Several decades ago, Suga and Sagawa opened a new window for cardiac mechanics and energetics, that were theconcepts of maximal elastance (Emax) and systolic pressure-volume area (PVA). The concepts of Emax and PVA havebecome basic frameworks of ventricular contraction and total ventricular contractile energy, respectively. Sunagawa andSagawa also defined a new framework of ventricular afterload, effective arterial elastance (Ea). Up to the present, theseframeworks have been widely used in physiological and clinical studies. On the other hand, recent developments ofmolecular biology and analytical methods may open another new window in the field of cardiac mechanics and energetics.
In this symposium, we will demonstrate recent advancesin this field and discuss the significances. This symposium will add a
new insight into cardiac mechanics and energetics.
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Posters Day 3

Keita Saku, Kenji Sunagawa

第94回⽇本⽣理学会⼤会

公募シンポジウム 36

J 会場  Symposium 36

Hall J

大会第3日：3月30日（木）・March 30（Thu） 8:50 - 10:50

発見から20年〜時計遺伝子研究の現在地

20 years from the discovery 〜 current location of clock gene study
オーガナイザー・Organizer：
池田 正明（埼玉医科大学医学部生理学/ゲノム医学研究センター 分子時計プロジェクト）
Masaaki Ikeda (Dept Physiol, Facl Med, RCGM, Saitama Med Univ)
田丸 輝也（東邦大学医学部 生理学講座 細胞生理学分野）
Teruya Tamaru (Dept Physiol, Toho Univ Sch Med)

3S36J1-1

時計遺伝子発見と進歩- 発見20年を振り返って○池田 正明1，熊谷 恵1,2
1埼玉医大・医・生理，2埼玉医大・ゲノム研・分子時計

The 20th anniversary of the discovery of mammalian clock genes
Masaaki Ikeda1, Megumi Kumagai1,2

1Dept Physiol, Facl Med, Saitama Med Univ, Saitama, Japan, 2RCGM, Saitama Med Univ, Saitama,Japan

3S36J1-2

概日リズムの同期発振を制御する時計遺伝子の分子基盤○田丸 輝也1，河村 玄気2，吉種 光3，深田 吉孝3，小澤 岳昌2，高松 研1
1 東邦大・医学部・細胞生理，2 東京大学 大学院 理学系研究科 化学専攻，3 東京大学 大学院理学系研究科
生物科学専攻Molecular basis in clock genes to control synchronous circadian oscillation
Teruya Tamaru1, Genki Kawamura2, Hikari Yoshitane3, Yoshitaka Fukada3,
Takeaki Ozawa2, Ken Takamatsu1

1Dept Physiol, Toho Univ Sch Med, Tokyo, Japan, 2Dept Chemistry, Sch Sci, Univ Tokyo, Tokyo,
Japan, 3Dept Biological Sci Sch Sci, Univ Tokyo, Japan

3S36J1-3

ADAR2はA-to-I編集リズムを介してRNAリズムを生み出す○吉種 光，寺嶋 秀騎，深田 吉孝
東大・院理・生科

Circadian epitranscriptome: ADAR2 catalyzes circadian A-to-I editing andregulates RNA rhythm
Hikari Yoshitane, Hideki Terajima, Yoshitaka Fukada
Dept Biological Sci, Grad Sch Sci, Univ Tokyo, Japan

3S36J1-4

自由行動マウスの複数組織における時計遺伝子発現のin vivo追跡定量化○浜田 俊幸 1，サザーランド リー ケネス 2，石川 正純 1,2,3,4，宮本 直樹 2，本間 さと 5，
白土 博樹4,6，本間 研一51北海道大・院医・分子追跡医学，2北海道大・院医・物理工学，3北海道大・院保健・医用生体理工学，
4北海道大・国際連携研究教育局，5北海道大・院医・時間生理学，6北海道大・院医・放射線医学

In vivo imaging of clock gene expression in multiple tissues of freely moving mice
Toshiyuki Hamada1, Kenneth Lee Sutherland2, Masayori Ishikawa1,2,3,4,
Naoki Miyamoto2, Sato Honma5, Hiroki Shirato4,6, Ken-ichi Honma5

1Applied Molecular-Imaging Physics, Hokkaido Univ Grad Sch Med, Sapporo, Japan, 2Med Physics
Engineering, Hokkaido Univ Grad Sch Med, Sapporo, Japan, 3Dept Biomed Sci Engineering,
Hokkaido Univ Grad Sch Health Sci, Sapporo, Japan, 4GI-CoRE, Hokkaido Univ, 5Chronomedicine,
Hokkaido Univ Grad Sch Med, Sapporo, Japan, 6Radiation Med, Hokkaido Univ Grad Sch Med,
Sapporo, Japan

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3S36J1-5‘Timing’ critical periods in brain development

Aims & Scope
Study of the mammalian clock genes, initiated with the discovery of “Clock gene“ by Joseph Takahashi and his colleagues,
will mark its 20th anniversary this year. Clock genes in the narrow sense, including Clock, Bmal1, Per1/2, Cry1/2, compose
the core of the molecular circadian clocks, pace-making and orchestrating various circadian physiological rhythms in thecells/tissues of whole body. This exactly manifests “the logic illuminating harmony of the moleculer interplay”. In this
symposium, we will look back at the history of clock gene study, and review/discuss current location of the understanding
for molecular clock machinery including other clock-related genes and transcriptional /post-transcriptional (e.g., RNA) /translational/post-translational (e.g., protein modification) regulatory processes, and strategies to capture the molecular
events in living cells/tissues/animals. Additionally, we will discuss that perturbation of various physiological harmonies by
impairment of clock gene functions, containing their critical roles in temporally organized physiologies and protective
adaptation, which becomes risk/aggravating factors for various health problems and diseases.

Symposia

1Dept Mol Cell Biol, Harvard Univ, Cambridge, USA, 2Dept Neurol, Boston Children’s Hospital,
Boston, USA

Lectures

Yohei Kobayashi1,2, Takao K Hensch1,2

Posters Day 3

Posters Day 2

Posters Day 1

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第94回⽇本⽣理学会⼤会

公募シンポジウム 37

D会場  Symposium 37

Hall D

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

シナプス機能を理解し、そして制御するための新しい化学・分子技術の展開

Development of novel chemical and molecular techniques for understanding andcontrolling synaptic integrity
オーガナイザー・Organizer：
掛川 渉（慶應義塾大学医学部 生理学教室）
Wataru Kakegawa (Dept Physiol I, Keio Univ Sch Med)
清中 茂樹（京都大学大学院工学研究科 合成・生物化学専攻）
Shigeki Kiyonaka (Dept Synth Chem & Biol Chem, Grad Sch Eng, Kyoto Univ)

3S37D2-1

神経回路の超解像マッピング
○今井 猛
理研CDB

Large-scale super-resolution mapping of neuronal circuits
Takeshi ImaiRIKEN Center for Developmental Biology, Kobe, Japan

3S37D2-2神経細胞および脳組織における内在性AMPA型グルタミン酸受容体の可視化および動態評価○清中 茂樹1，浜地 格1,2
1京大・院工・合成生物化学，2JST CREST

Chemical labeling for visualizing native AMPA-type glutamate receptors in live
neurons
Shigeki Kiyonaka1, Itaru Hamachi1,21Dept Synth Chem & Biol Chem, Grad Sch Eng, Kyoto Univ, Kyoto, Japan, 2CREST, JST, Japan

3S37D2-3

小脳長期抑圧の制御技術開発と運動学習メカニズムの解析○松田 信爾1,2
1電通大・院情報理工・基盤理工，2科学技術振興機構 さきがけ

Analysis of the relationship between cerebellar LTD and motor learning by novel
optogenatical toolShinji Matsuda1,2

1Dept Engineering Sci, Grad Sch Informatics and Engineering, Univ Electro-Communications,Tokyo, Japan, 2JST PRESTO, Saitama, JAPAN3S37D2-4

新しいデザイナーシナプスコネクターを用いたシナプス形成・可塑性の制御○鈴木 邦道1，掛川 渉1，三浦 絵里子1，エレグハート ジョナサン2，
クレイトン アンバー 2，アリセク エイ ラドゥー 2，柚崎 通介11慶應義塾大学・医学部・生理学I，2オックスフォード大学・ヒト遺伝学ウェルカムトラストセンター・構

造生物学

A novel designer synapse connector: for the control of synapse formation andplasticity

Kunimichi Suzuki1, Wataru Kakegawa1, Eriko Miura1, Jonathan Elegheert2,
Amber Clayton2, Radu A Aricescu2, Michisuke Yuzaki1

1Dept Physiol I, Keio Univ Sch Med, Tokyo, Japan, 2Div Struc Biol, Wellcome Trust Ctr Hum Genet,
Univ Oxford, London, UK

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Symposia

Our brains contain billions of neurons, which connect with each other through synapses. Synapses underlie not only
neurotransmission but also learning and memory. Furthermore, various neurological and psychiatric diseases reportedly
involve abnormalities of synapse formation and function. Therefore, it is essential to understand how synapses are formed
and behave in vivo in both physiological and pathological contexts. Recently, there have been dramatic advances across anarray of chemical and molecular techniques for exploring detailed mechanisms underlying synaptic integrity. In this
symposium, four young scientists will discuss recent advances in chemical/molecular tools and techniques useful forunderstanding and manipulating synaptic integrity. Matsuda et al. will introduce a new optogenetic tool that controls
synaptic AMPA receptor trafficking and motor learning, while Kiyonaka et al. will discuss a chemical labeling method forvisualizing native AMPA receptors. Imai et al. will introduce an improved technique for brain tissue clearing, which enables
the large-scale analysis of fine synaptic structures. Suzuki et al. will detail new techniques for regulating synaptic functions
and animal behaviors using artificial synaptic connectors/disconnectors. We hope that this symposium will provide key
insights into the mechanisms underlying synaptic integrity and will be impactful to the conference audience.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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公募シンポジウム 38

E 会場  Symposium 38

Hall E

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

酸素濃度変化が起点となる心血管生理調節機構

Remodeling of cardiovascular system driven by oxygen
オーガナイザー・Organizer：
佐藤 元彦（愛知医科大学医学部 生理学講座）
Motohiko Sato (Dept Physiol, Aichi Med Univ)
横山 詩子（横浜市立大学医学部 循環制御医学）
Utako Yokoyama (Cardi Res, Yokohama City Univ Med)

3S38E2-1

虚血組織における血管新生シグナル制御○佐藤 元彦，マムン アル アブドラ，林 寿来
愛知医科大学・生理学

Regulation of angiogenic signals in the ischemic tissue
Motohiko Sato, Abdullah Al Mamun, Hisaki Hayashi
Dept Physiol, Aichi Med Univ, Nagakute, Japan

3S38E2-2酸素化により動脈管は解剖学的閉鎖を誘導する○金 美花1,2，横山 詩子2，石渡 遼2，南沢 享3，石川 義弘2
1国循・肺高血圧症先端医学部，2横浜市立大学・医学研究科・循環制御医学，3東京慈恵会医科大学・細胞生理学講座

Oxygenation-induced postnatal remodeling of the ductus arteriosus

Meihua Jin1,2, Utako Yokoyama2, Ryo Ishiwata2, Susumu Minamisawa3,
Yoshihiro Ishikawa2
1Dept Adv Med Res, NCVC, Osaka, Japan, 2Cardi Res, Yokohama City Univ Med, Yokohama, Japan,
3Dept Cell Physiol, Jikei Univ Sch Med, Tokyo, Japan

3S38E2-3低酸素誘導性肺血管リモデリングにおける炎症細胞の役割○武田 憲彦1,2
1東大・医・循環器，2JSTさきがけ

The role of inflammatory cells in hypoxia-induced pulmonary artery
remodelling
Norihiko Takeda1,2

1Dept Cardiovasc Med, Grad Sch Med, Univ Tokyo, Tokyo, Japan, 2PRESTO, JST

3S38E2-4血管リモデリングにおける低酸素応答因子HIF-1の役割○冨田 修平
大阪市大・院医・分子病態薬理学

Role of hypoxia inducible factor-1 in vascular remodeling
Shuhei Tomita
Dept Pharmacol, Osaka City Univ Grad Sch Med, Osaka, Japan

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Symposia

Oxygen is an essential substrate to maintain life system. Change of oxygen content induces physiological andpathophysiological responses in cells that lead to remodeling of tissues. Adaptation of cells to a new set point of oxygen is
accompanied by alteration of signal transduction in hormone- and oxygen-mediated pathways. Although oxygen
influences various responses in multiple tissues, this symposium will focus on cardiovascular events and signal alteration
operated by oxygen. Decrease of oxygen content influences cell proliferation, angiogenesis, pulmonary artery remodeling,metabolic pathway and survival, that are associated with change of hypoxia-inducible factors expression, inflammatory
signals or signal transduction mediated by vascular endothelial growth factor, angiotensin II and heterotrimeric G-protein.
On the other hand, the dramatic increase of oxygen tension at birth causes transformation of the circulation system, whichis concomitant with extracellular matrix remodeling in the artery walls. The recent advances of those topics will bepresented and discussed in this symposium. The symposium will contribute to our understanding of signal alteration andcardiovascular responses elicited by oxygen.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

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F 会場  Symposium 39

公募シンポジウム 39

Hall F

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

日本理学療法士協会連携シンポジウム
実験室から日常生活をつなぐ認知機能研究

Joint Symposium with Japanese Physical Therapy Association
A bridge of cognitive function studies between laboratory and daily life
オーガナイザー・Organizer：
小峰 秀彦（産業技術総合研究所 自動車ヒューマンファクター研究センター 生理機能研究チーム）
Hidehiko Komine (Automotive Human Factors Research Center, National Institute of Advanced Industrial Scienceand Technology)
金子 文成（札幌医科大学保健医療学部 理学療法学科）
Fuminari Kaneko (School of Health Science, Sapporo Medical University)

3S39F2-1

物体再認課題を用いた経頭蓋電気刺激法の評価○渡辺 由美子1，武井 宙之 1,2，高島 一郎11産総研・人間情報，2筑波大学

Assessment of transcranial electrical stimulations using object recognition tasks
Yumiko Watanabe1, Hiroyuki Takei1,2, Ichiro Takashima1
1AIST, Tsukuba, Japan, 2Univ Tsukuba, Tsukuba, Japan

3S39F2-2

脳活動計測技術を用いた実環境における認知機能の評価○岩木 直，武田 裕司，佐藤 稔久
産総研・AHFRCElectrophysiological measures to evaluate cognitive performance in real-world
behavior
Sunao Iwaki, Yuji Takeda, Toshihisa Sato
AHFRC, Natl Inst Adv Indust Sci Tech (AIST), Tsukuba, Japan

3S39F2-3

高齢者における認知機能と脳○土井 剛彦国立長寿医療研究センター

Cognitive function and brain in older adults
Takehiko Doi
Natl Ctr Geriatrics Gerontol, Aichi, Japan

3S39F2-4

地域における認知症予防のスキーム○島田 裕之国立長寿医療研究センター

Scheme for preventing dementia in the community
Hiroyuki Shimada
Natl Ctr Geriatrics Gerontol, Aichi, Japan

ねらいと概要高齢化の進展に伴って、認知症患者あるいは認知機能の低下した人の増加が社会的課題となりつつある。認知機能を予防・回復するためのエビデンス構築のためには、生理学的アプローチによるメカニズムの解明から、日常生活におけるフィールドスタディまでを横断的かつ相互補完的に進める必要がある。本シンポジウムでは、生理学会と理学療法士協会とが連携し、実験室レベルでの生理学研究から、認知機能低下者に対するリハビリテーションによる介入効果に関する研究発表を行う。これにより、実験室レベルで行う生理学的研究とフィールドを中心行う理学療法研究とが双方の長所を取り入れ、新たな研究展開へとつながることを期待する。
※本シンポジウムは全て日本語で開催されます。

This symposium will be held in Japanese.

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公募シンポジウム 40

H 会場  Symposium 40

Hall H

Lectures

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

概日時計システムの脳内機構

Circadian clock system in the mammalian brain

三枝 理博（金沢大学医学系分子神経科学 統合生理学）
Michihiro Mieda (Dept Mol Neurosci, Grad Sch Med Sci, Kanazawa Univ)

3S40H2-1

Optical detection of circadian voltage rhythms in the suprachiasmatic nucleus

Ryosuke Enoki1,2, Yoshiaki Oda1, Michihiro Mieda5, Daisuke Ono4, Sato Honma3,
Ken-ichi Honma3

Symposia

オーガナイザー・Organizer：
榎木 亮介（北海道大学大学院医学研究科 光バイオイメージング部門）
Ryosuke Enoki (Photonic Bioimaging, Hokkaido Univ, Grad Sch Med)

1Photonic Bioimaging, Hokkaido Univ, Grad Sch Med, Sapporo, Japan, 2JST PRESTO, 3Res&Educ

Center Brain Sci, Hokkaido Univ, Grad Sch Med, Sapporo, Japan, 4Nagoya Univ, Dep of Neurosci II,
Nagoya, Japan, 5Kanazawa Univ, Grad Sch Med Sci, Kanazawa, Japan

3S40H2-2

バソプレシン産生ニューロンは視交叉上核のペースメーカー機能に重要な役割を果たす○三枝 理博金沢大・院医・分子神経科学

AVP neurons play a critical role in the circadian pacemaking of SCN
Michihiro Mieda

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物体認識記憶の概日変動を生み出す分子メカニズム○清水 貴美子，小林 洋大，仲辻 英里香，深田 吉孝
東大・院理・生科

Molecular mechanism of circadian regulation of recognition memory
Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Yoshitaka Fukada
Dept Biol Sci, Grad Sch Sci, Univ Tokyo, Tokyo, Japan

概日光受容体メラノプシンの機能と性質

Posters Day 2

3S40H2-4○羽鳥 恵
慶應・医・眼・光生物

Mechanisms and properties of signaling by melanopsin retinal ganglion cells
Megumi Hatori
Photobiology lab, Dept Ophthalmol, Sch Med, Keio Univ, Tokyo, Japan

3S40H2-5

体内時計の中枢を制御するGz共役型オーファンGPCRシグナル○土居 雅夫，岡村 均
京大・院薬・医薬創成情報科学

Identification of a Gz-linked orphan GPCR that tunes the center of the circadianclock
Masao Doi, Hitoshi Okamura
Dept Syst Biol, Grad Sch Pharmaceut Sci, Kyoto Univ, Kyoto, Japan

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Posters Day 3

3S40H2-3

Posters Day 1

Dept Mol Neurosci, Grad Sch Med Sci, Kanazawa Univ, Kanazawa, Japan

第94回⽇本⽣理学会⼤会

Aims & Scope
The circadian clock in most living organisms on earth makes it possible to coordinate their biology with daily environmental
changes. In mammals, the master circadian clock is located in the hypothalamic suprachiasmatic nucleus (SCN), which
controlsdaily rhythms in physiology and behavior, such as sleep-wake cycle. At single cell level, recent studies revealed that
individual cellular oscillators are driven by autoregulatory transcriptional/post-translational feedback loops (TTFLs) involving
clock genes and their products. In contrast, network- and system-level mechanisms underlying the circadian clock in thebrain remain largely unknown. Aim of this symposium is to present the recent research topics on circadian system in the
mammalian brain, such as high-resolution multi-color imaging (Enoki) and cell-type specific genetic manipulation (Mieda)of the SCN neural network, screening/analysis of novel GPCR specifically expressed in the SCN (Doi), characterization ofregulators and cellular/neural pathways that mediate photic entrainment (Hatori), and clock-controlled memory formationin the hippocampus (Shimizu). We will discuss future direction toward the comprehensive understanding of circadiansystem in mammalian brain.

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公募シンポジウム 41

I 会場  Symposium 41

Hall I

Lectures

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

呼吸ニューロンネットワーク機構の多階層的理解：
延髄スライスでの微小神経回路から覚醒動物まで

Multi-level understanding of the respiratory neuron network function:from microcircuit in medullary slices to freely moving conscious animals

Symposia

オーガナイザー・Organizer：
岡田 泰昌（独立行政法人国立病院機構村山医療センター 臨床研究部 電気生理学研究室）
Yasumasa Okada (Clin Res Ctr, Murayama Medical Ctr)
越久 仁敬（兵庫医科大学生理学 生体機能部門）
Yoshitaka Oku (Dept Physiol, Hyogo College of Medicine)

マウス延髄スライス標本のpre-Botzinger complexにおける自発的同期活動を起こす興奮性ならびに抑制性の吸息性ニューロンの活性化パターン

1兵庫医大・生理・生体機能，2統数研・モデリング，3ドイツ・ライプツィヒ大学・カールルートヴィヒ生理学研究所，4ドイツ・ゲッティンゲン大学・麻酔学部門

Rhythmic activation patterns of excitatory/inhibitory inspiratory neurons in the
pre-Botzinger complex of the mice medulla slice
Yoshihiko Oke1, Fumikazu Miwakeichi2, Yoshitaka Oku1, Stefanie Besser3,
Johannes Hirrlinger3, Swen Huelsmann4

1Dept Physiol, Hyogo College of Medicine, Hyogo, Japan, 2Dept Stats Modeling, Inst Stats Math,

Tokyo Japan, 3Carl-Ludwig-Institute for Physiol, Univ Leipzig, Leipzig, Germany, 4Clinic forAnesthesiol, Gottingen Univ, Gottingen, Germany

3S41I2-2新生ラット摘出脳幹-脊髄標本における呼吸リズム形成○林 思女亭1，鬼丸 洋2
1昭和大・薬・薬物治療学，2昭和大・医・生体調節機能学

Respiratory rhythm generation in the in vitro brainstem-spinal cord preparationof the neonatal rat
Shih-Tien Lin1, Hiroshi Onimaru2

1Dept Pharmacother, Div Clin Pharm, Showa Univ, Tokyo, Japan, 2Dept Physiol, Sch Med, Showa

Univ, Tokyo, Japan

呼吸ニューロンネットワークの研究のための除皮質灌流標本○矢澤 格
星薬科大・生命科学研

A decerebrates and artificially-perfused in situ preparation for the study of
respiratory neuron network

Posters Day 3

3S41I2-3

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Posters Day 1○尾家 慶彦1，三分一 史和2，越久 仁敬1，ベッサー ステファニー 3，
ヒルリンガー ヨハネス3，ヒュルスマン スベン4

Posters Day 2

3S41I2-1

Itaru Yazawa
Hoshi Univ Sch Pharm Pharmaceut Sci, Tokyo, Japan

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3S41I2-4

呼吸と循環機能の協調的な調節における中脳の役割○堀内 城司，吉岡 優海，高橋 知幸
東洋大学・理工・生体医工Role of the midbrain in coordinated regulation of respiratory and cardiovascularfunction in anesthetized animals
Jouji Horiuchi, Yuumi Yoshioka, Tomoyuki Takahashi
Dept Biomed Engin, Toyo Univ, Saitama, Japan

3S41I2-5

自発呼吸下の覚醒マウスにおける低酸素換気応答とアストロサイトの役割○福士 勇人1,2，武田 湖太郎1,3，寺田 二郎1,4，ミエチスラフ ポコルスキー 1,5，
堀内 城司2，岡田 泰昌1
1 村山医療センター・臨床研究部，2 東洋大・院理工・生体医工，3 藤田保健衛生大・藤田記念七栗研究所，
4千葉大・呼吸内科，5Opole Medical School, Opole, Poland

Hypoxic ventilatory response in conscious mice

Isato Fukushi1,2, Kotaro Takeda1,3, Jiro Terada1,4, Pokorski Mieczyslaw1,5,
Jouji Horiuchi2, Yasumasa Okada1
1Clin Res Ctr, Murayama Medical Ctr, Tokyo, Japan, 2Dept Biomed Eng, Grad Sch Sci & Eng, Toyo
Univ, Saitama, Japan, 3Fujita Memorial Nanakuri Inst, Fujita Health Univ, Mie, Japan, 4Dept
Respirology, Chiba Univ, Chiba, Japan, 5Opole Medical School, Opole, Poland

Aims & Scope
Basic respiratory rhythm is generated primarily in the medulla. However, final respiratory motor output is formed byinterconnected neuron networks distributed from the higher brain to the spinal cord. To precisely and comprehensively
understand how respiratory rhythm is generated and ventilation is regulated to maintain homeostasis, it is necessary to
elucidate the respiratory neuron network mechanisms at multi-levels, i.e., from the microcircuit to the whole animal. In the
proposed symposium, we will introduce the latest studies conducted from microscopic to macroscopic viewpoints: (1)Respiratory rhythm generation in the microcircuit in the pre-Bötzinger complex (preBötC) using thin transverse slices of the
medulla (by Oke). (2) Respiratory control in the parafacial respiratory group (pFRG), another primary oscillator longitudinallycoupled with the preBötC, using isolated brainstem-spinal cord preparations of neonatal rodents (by Lin). (3) Respiratory
control in the more intact and mature condition using decerebrated, arterially perfused in situ preparations (by Yazawa). (4)Respiratory as well as cardiovascular neuron network function analyzed in anesthetized whole animals (Horiuchi). (5)Ventilation and its responses to various physiological stimuli such as hypoxia in unrestrained conscious animals (by Fukushi).
These multi-level approaches would enable us to better understand the respiratory neuron network function in health anddisease.

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The 94th Annual Meeting of the Physiological Society of JapanJ 会場  Symposium 42

Hall J

Lectures

大会第3日：3月30日（木）・March 30（Thu） 14:30 - 16:30

宇宙生理学の新展開 −臨床医学との融合−

Frontier in space physiology and medicine – from bench to bedside –オーガナイザー・Organizer：
後藤 勝正（豊橋創造大学大学院 健康科学研究科）
Katsumasa Goto (Lab Physiol, Sch Health Sci, Toyohashi SOZO Univ)
河合 康明（鳥取大学医学部 適応生理学）
Yasuaki Kawai (Division of Adaptation Physiology, Tottori University Faculty of Medicine)

3S42J2-1

熱ショック転写因子1の欠損は荷重除去によるミオシン重鎖の速筋化を抑制する○横山 真吾1，大平 充宣2，吉岡 利忠3，後藤 勝正1,4
1豊橋創造大・保健医療，2同志社大・院スポーツ健康科学，3弘前学院大，4豊橋創造大・院健康科学

Deficiency of heat shock transcription factor 1 suppresses unloading-associatedslow-to-fast transition of myosin heavy chain isoforms in mouse soleus muscle

Symposia

公募シンポジウム 42

Shingo Yokoyama1, Yoshinobu Ohira2, Toshitada Yoshioka3, Katsumasa Goto1,4

宇宙環境暴露による循環調節障害の機序：今後の研究展望を踏まえて○和気 秀文，山中 航
順天堂大・院スポ健・生理

Mechanisms underlying cardiovascular deconditioning induced by space flight:
current and future prospects
Hidefumi Waki, Ko Yamanaka
Dept Physiol, Grad Sch Health and Sports Science, Juntendo Univ, Chiba, Japan

3S42J2-3

再生医療実現を目指した高効率骨格筋前駆細胞誘導法の開発○細山 徹
山口大学・院医・器官病態外科

High efficient derivation of skeletal muscle progenitor cells from humanpluripotent stem cells for regenerative medicine
Tohru Hosoyama
Dept Surg Clinic Sci, Yamaguchi Univ Grad Sch Med, Ube, Japan

3S42J2-4

宇宙酔い発症における前庭系のかかわり−スペースシャトル上で行われた実験結果を踏
まえて−
○肥塚 泉
聖マリアンナ医大・耳鼻咽喉科

Space motion sickness and vestibular system –based on the results of the
NeuroLab experiment at space shuttle Columbia (STS-90)–
Izumi Koizuka
Dept Otolaryngol, St. Marianna Univ Sch Med, Kanagawa, Japan

Aims & Scope
Functions and structures of organs in mammals have been developed under 1-G environment on Earth. Therefore,
exposure to microgravity during spaceflight as well as to simulated microgravity impacts on physiological functions invarious organs such as bone, skeletal muscle, heart, vestibular organ, and so on. Scientific researches in this field could
provide us new aspects for both physiological and clinical approaches. In this symposium, we will discuss novel evidences ofspace and gravitational physiology and their applications in clinical medicine, showing a new insight and a future direction
into the translational research.
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Posters Day 1

3S42J2-2

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Posters Day 2

Doshisha Univ, Kyoto, Japan, 3Hirosaki Gakuin Univ, Aomori, Japan, 4Dept Physiol, Grad Sch
Health Sci, Toyohashi SOZO Univ, Aichi, Japan

Posters Day 3

1Lab Physiol, Sch Health Sci, Toyohashi SOZO Univ, Aichi, Japan, 2Grad Sch Health Sports Sci,