第94回⽇本⽣理学会⼤会

公募シンポジウム 1

A 会場  Symposium 1

Hall A

大会第1日：3月28日（火）・March 28（Tue） 9:50 - 11:50【味の素株式会社協賛】
情動行動における口腔・腸̶脳連関の重要性【Supported by Ajinomoto Co., Inc.】

Oral/gut-brain interaction in emotional behavior
オーガナイザー・Organizer：
飛田 秀樹（名古屋市立大学 医学研究科 脳神経生理学）
Hideki Hida (Dept of Neurophysiol & Brain Sci, Nagoya City Univ Grad Sch Med Sci)
二ノ宮 裕三（九州大学 味覚・嗅覚センサ研究開発センター）
Yuzo Ninomiya (Div Sens Physiol, R&D Ctr Taste Odor Sens, Kyushu Univ)

1S01A1-1

口腔腸脳機能分子連関: グルコース輸送体を介する甘味受容伝達経路○二ノ宮 裕三1,2，中野 啓子1,3，大栗 弾宏3，岩田 周介2,3，高井 信吾3，吉田 竜介3，重村 憲徳3，マルゴルスキー ロバート2,3
1九大・味覚嗅覚研究センター，2米国モネル化学感覚研，3九大・院歯・口腔機能

Oral-gut-brain linkage with molecules involved in glucose-sensing sweet taste
pathway

Yuzo Ninomiya1,2, Keiko Nakano1,3, Tadahiro Ohkuri3, Shusuke Iwata2,3,
Shingo Takai3, Ryusuke Yoshida3, Noriatsu Shigemura3, Robert Margolskee2,3

1Div Sens Physiol, R&D Ctr Taste Odor Sens, Kyushu Univ, Fukuoka, Japan, 2Monell Chem SensCtr, Philadelphia, USA, 3Sect Oral Neurosci, Grad Sch Dent Sci, Kyushu Univ, Fukuoka, Japan

1S01A1-2

かつおだし摂取がマウスの情動行動に及ぼす効果とその神経メカニズム○西丸 広史1，Jargalsaikhan Undarmaa1，松本 惇平1，高村 雄策1，中村 友也1，掘 悦郎1，近藤 高史 2，小野 武年1，西条 寿夫1
1富山大・院医・システム情動科学，2（株）味の素・イノベーション研究所

Effects of dried-bonito broth (dashi) ingestion on emotional behaviors and their
possible mechanism in young mice

Hiroshi Nishimaru1, Undarmaa Jargalsaikhan1, Jumpei Matsumoto1,Yusaku Takamura1, Tomoya Nakamura1, Etsuro Hori1, Takashi Kondoh2,Taketoshi Ono1, Hisao Nishijo1

1Syst Emotional Sci, Univ Toyama, Toyama, Japan, 2Inst Innovation, Ajinomoto Co, Inc, Kawasaki,
Japan

1S01A1-3

注意欠陥多動性モデルラットでの発育期のグルタミン酸ナトリウムによる攻撃性の減少
は胃迷走神経を介する○飛田 秀樹，横山 善弘，丸本 良介，三角 吉代，西垣 瑠里子，永井 遥，上田 佳朋，
石田 章真，鄭 且均
名古屋市大・院医・脳神経生理

Decreased aggression by monosodium glutamate during the period ofdevelopment is mediated by vagus nerve in an attention-deficit hyperactivity
disorder model rat
Hideki Hida, Yoshihiro Yokoyama, Ryosuke Marumoto, Sachiyo Misumi,Ruriko Nishigaki, Haruka Nagai, Yoshitomo Ueda, Akimasa Ishida, Cha-gyun Jung
Dept Neurophysiol & Brain Sci, Nagoya City Univ Grad Sch Med Sci, Nagoya, Japan90

The 94th Annual Meeting of the Physiological Society of Japan

1S01A1-4

うつ病や関連疾患における腸内細菌の役割○功刀 浩

Lectures

国立精・神医研セ・疾病三部

Role of gut microbiota in depression and related disorders
Hiroshi Kunugi
Dept Mental Disorder Research, NCNP, Tokyo, JapanThe gut and the brain are closely connected. Recent neurobiological studies in this gut-brain crosstalk have revealed
bidirectional communication system by neural communication (vagal, sympathetic) and systemic communication (HPA axis,neurotransmitters, bacterial metabolites, cytokines). This gut-brain crosstalk is likely to have multiple effects on affection,motivation, and higher cognitive functions. Disturbances of this system have been implicated in a wide range of disorders,
including anxiety, depression and neurodevelopmental disease such as attention-deficit hyperactivity disorder (ADHD).
In this symposium, we focused on the effect of taste substances on emotional behavior from the aspect of “oral/gut-braininteraction”. The importance of oral/gut-brain interactions will be shown by at least four speakers. Dr. Ninomiya will present
new data showing sugar sensing pathway in the gut is also found in taste cells in the oral cavity. Dr. Nishimaru will present
the effect of “umami” and “dashi” on the emotional behavior focusing on the amygdala and the prefrontal cortex. Dr. Hida
will show the effect of an umami substance on aggressive behavior in an ADHD model rat, which is mediated by vagus
nerve. Dr. Kunugi will show the importance of the gut-brain interaction in anxiety and depression.

Symposia

Aims & Scope

Posters Day 3Posters Day 2

Posters Day 1

教育プログラム91第94回⽇本⽣理学会⼤会

企画シンポジウム 2

A 会場  Planned Symposium 2

Hall A

大会第1日：3月28日（火）・March 28（Tue） 16:40 - 18:40【株式会社ミユキ技研協賛】
てんかん病態の基礎と臨床のtranslatability：オシロロジーからのアプローチ【Supported by Miyuki Giken Co., Ltd.】The translatability between basic and clinical studies for the pathophysiology of epilepsy:
approach from oscillology
オーガナイザー・Organizer：
長峯 隆（札幌医科大学医学部 神経科学講座）
Takashi Nagamine (Department of Systems Neuroscience, School of Medicine, Sapporo Medical University)
池田 昭夫（京都大学大学院医学研究科 てんかん・運動異常生理学講座）
Akio Ikeda (Dept Epilepsy Movement Disorders Physiol, Kyoto Univ Grad Sch Med)

1PS02A2-1

今日のてんかん病態の理解と未解決の問題点○池田 昭夫
京都大・院医・てんかん運動異常

Overview of current state of epilepsy and unsolved problems
Akio Ikeda
Dept Epilepsy Movement Disorders Physiol, Kyoto Univ Grad Sch Med, Kyoto, Japan

1PS02A2-2

基礎研究からのアプローチー Scn1a遺伝子変異ラットを用いた高体温感受性痙攣の電気生理学的研究ー○大守 伊織1，小林 勝弘2
1岡山大・院教育・特別支援教育，2岡山大・院医歯薬・発達神経病態学

Approach from basic and molecular study -Electrophysiological study ofhyperthermia-induced seizures in Scn1a mutant ratsIori Ohmori1, Katsuhiro Kobayashi2

1Dept Special Needs Education, Okayama Univ Grad Sch Edu, Okayama, Japan, 2Dept ChildNeurol, Okayama Univ Grad Sch Med Dent Pharm Sci, Okayama, Japan

1PS02A2-3

てんかん原性と関連ネットワーク：臨床神経生理学的アプローチ○松本 理器1，小林 勝哉1，菊池 隆幸2，吉田 和道2，國枝 武治3，池田 昭夫4
1京都大・院医・臨床神経学，2京都大学大学院医学研究科脳神経外科学，3愛媛大学大学院医学系研究科脳神経外科学，4京都大学大学院医学研究科てんかん・運動異常生理学講座

Epileptogenicity and related network: Approach from clinical neurophysiology

Riki Matsumoto1, Katsuya Kobayashi1, Takayuki Kikuchi2, Kazumichi Yoshida2,Takeharu Kunieda3, Akio Ikeda41Dept Neurol, Kyoto Univ Grad Sch Med, Kyoto, Japan, 2Dept Neurosurgery, Kyoto Univ Grad SchMed, Kyoto, Japan, 3Dept Neurosurgery, Ehime Univ Grad Sch Med, Toon, Japan, 4Dept Epilepsy
Movement Disorders Physiol, Kyoto Univ Grad Sch Med, Kyoto, Japan

1PS02A2-4

脳の動的活動状態に埋め込まれた数学的構造の発見：理論と応用○津田 一郎，行木 孝夫
北大・理学研究院・数学部門

Finding mathematical structures in the brain dynamics: theory and its
application
Ichiro Tsuda, Takao Namiki
Dept Math, Grad Sch Sci, Hokkaido Univ, Sapporo, Japan62

The 94th Annual Meeting of the Physiological Society of JapanSymposia

Epilepsy is one of the common disorders of the central nervous system, and neurons produce extraordinarily hyperexcitable
activity and clinically epileptic seizures occurred. It is caused by either increased excitation or decreased inhibition
depending on the various causes, and thus the treatment regimen also may depend on it. Both neurons and glia generates
even very high frequency- and infraslow activity respectively which makes the analysis of physiological data muchcomplicated. Since clinical neurophysiological data have been obtained by invasive EEG and by microelectrodes, a directcomparison between clinical situation and animal study is more plausible and translatability between the two is one of themost important approaches to solve the clinical and fundamental problems in epilepsy. In this symposium, the following
different approaches are introduced. 1) Overview of current state of epilepsy and unsolved problems, 2) Approach frombasic and molecular studies, 3) Approach from clinical neurophysiology, 4) Approach from mathematical analysis andmodeling. Upon those translatable approaches, it is expected that both normal cortical function and epileptic symptoms
may share the similar and dissimilar spectrum of physiological property as well as genetic property. It is also expected thattheoretical analysis of epileptic neurophysiological property and its subsequent modeling may help establish conceptual
basic principle and common framework of epileptic abnormality.

Lectures

Aims & Scope

Posters Day 3

Posters Day 2

Posters Day 1

教
育プログラム63