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Chiba S, Hisamatsu T, Suzuki H, Mori K, Kitazume MT, Shimamura K,Mizuno S, Nakamoto N, Matsuoka K, Naganuma M, Kanai T. Glycolysis
regulates LPS-induced cytokine production in M2 polarized humanmacrophages. Immunol Lett 2017;183:17-23.
Chu PS, Nakamoto N, Taniki N, Ojiro K, Amiya T, Makita Y, Murata H,
Yamaguchi A, Shiba S, Miyake R, Katayama T, Ugamura A, Ikura A, TakedaK, Ebinuma H, Saito H, Kanai T. On-treatment decrease of NKG2D
correlates to early emergence of clinically evident hepatocellular carcinoma
after interferon-free therapy for chronic hepatitis C. PLoS One
2017;12:e0179096.
Fukuda T, Naganuma M, Sugimoto S, Nanki K, Mizuno S, Mutaguchi M,
Nakazato Y, Inoue N, Ogata H, Iwao Y, Kanai T. The risk factor of clinicalrelapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as
maintenance therapy: A report from the IBD registry. PLoS One
2017;12:e0187737.
Fukuhara S, Masaoka T, Nishimura S, Nakamura M, Matsuzaki J, Tsugawa
H, Miyoshi S, Mori H, Kawase S, Shibata S, Okano H, Kanai T, Suzuki H.
Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency
Contributes to Delayed Gastric Emptying. Dig Dis Sci 2017;62:3359-3369.
Hamamoto Y, Nojima M, Aoki Y, Suzuki T, Kawasaki K, Hirata K, Sukawa
Y, Kasuga A, Kawakubo H, Takeuchi H, Murakami K, Takaishi H, Kanai T,Kitagawa Y. Inter-evaluator heterogeneity of clinical diagnosis for locallyadvanced esophageal squamous cell carcinoma. Esophagus 2017;14:324-332.
Hayashi A, Mikami Y, Miyamoto K, Kamada N, Sato T, Mizuno S,Naganuma M, Teratani T, Aoki R, Fukuda S, Suda W, Hattori M, Amagai M,
Ohyama M, Kanai T. Intestinal Dysbiosis and Biotin Deprivation Induce
Alopecia through Overgrowth of Lactobacillus murinus in Mice. Cell Rep
2017;20:1513-1524.
Hirata K, Yokoyama A, Nakamura R, Omori T, Kawakubo H, Mizukami T,Maruyama K, Kanai T, Yokoyama T. Soft palatal melanosis, a simple
predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholicmen. Cancer Sci 2017;108:1058-1064.
Horibe M, Sasaki M, Sanui M, Sugiyama D, Iwasaki E, Yamagishi Y,Sawano H, Goto T, Ikeura T, Hamada T, Oda T, Yasuda H, Shinomiya W,
Miyazaki D, Hirose K, Kitamura K, Chiba N, Ozaki T, Yamashita T,
Koinuma T, Oshima T, Yamamoto T, Hirota M, Moriya T, Shirai K, Mayumi
T, Kanai T. Continuous Regional Arterial Infusion of Protease Inhibitors
Has No Efficacy in the Treatment of Severe Acute Pancreatitis: ARetrospective Multicenter Cohort Study. Pancreas 2017;46:510-517.
Hosoe N, Ohmiya N, Hirai F, Umeno J, Esaki M, Yamagami H, Onodera K,Bamba S, Imaeda H, Yanai S, Hisamatsu T, Ogata H, Matsumoto T. ChronicEnteropathy Associated With SLCO2A1 Gene [CEAS]-Characterisation of
an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn's
Disease. J Crohns Colitis 2017;11:1277-1281.
Ikeura T, Horibe M, Sanui M, Sasaki M, Kuwagata Y, Nishi K, Kariya S,Sawano H, Goto T, Hamada T, Oda T, Yasuda H, Ogura Y, Miyazaki D,Hirose K, Kitamura K, Chiba N, Ozaki T, Yamashita T, Koinuma T, Oshima
T, Yamamoto T, Hirota M, Yamamoto S, Oe K, Ito T, Iwasaki E, Kanai T,Okazaki K, Mayumi T. Validation of the efficacy of the prognostic factor

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score in the Japanese severity criteria for severe acute pancreatitis: A large
multicenter study. United European Gastroenterol J 2017;5:389-397.
Kashiwagi K, Inoue N, Yoshida T, Bessho R, Yoneno K, Imaeda H, Ogata H,Kanai T, Sugino Y, Iwao Y. The impact of visceral adipose tissue as best
predictor for difficult colonoscopy and the clinical utility of a longsmall-caliber scope as rescue. PLoS One 2017;12:e0189817.
Kashiwagi K, Inoue N, Yoshida T, Bessyo R, Yoneno K, Imaeda H, Ogata H,Kanai T, Sugino Y, Iwao Y. Polyp detection rate in transverse and sigmoid
colon significantly increases with longer withdrawal time during screeningcolonoscopy. PLoS One 2017;12:e0174155.
Kashiwagi K, Nakazato Y, Arai M, Iwasaki E, Naganuma M, Inoue N, Iwao
Y, Ogata H, Murakami K, Kanai T. Limited Identification of Dual-time-point
Positron Emission Tomography/Computed Tomography in Advanced
Colorectal Neoplasms. Intern Med 2017;56:1287-1292.
Kasuga A, Hamamoto Y, Takeuchi A, Kawasaki K, Suzuki T, Hirata K,Sukawa Y, Takaishi H, Kanai T. Positive relationship between subsequentchemotherapy and overall survival in pancreatic cancer: meta-analysis ofpostprogression survival for first-line chemotherapy. Cancer ChemotherPharmacol 2017;79:595-602.
Kawasaki K, Hamamoto Y, Horibe M, Shimura K, Nakamura A, Kanai T,Takaishi H. Curative resectability of gastrointestinal cancer identified fromiron deficiency anemia. Oncol Lett 2017;14:4301-4304.
Kawasaki K, Hamamoto Y, Suzuki T, Hirata K, Sukawa Y, Kasuga A,Hayashi Y, Takaishi H, Kameyama K, Kanai T. Benefit of rebiopsy for
deciding treatment strategy in rectal cancer: A case report. Oncol Lett
2017;14:3697-3700.
Kinoshita S, Nishizawa T, Hisamatsu T, Kanai T, Yahagi N. Polyglycolicacid sheet for closure of esophagobronchial fistula in a patient with Behcet's
disease. Gastrointest Endosc 2017;85:1094-1096.
Kinoshita S, Nishizawa T, Ochiai Y, Uraoka T, Akimoto T, Fujimoto A,
Maehata T, Goto O, Kanai T, Yahagi N. Accuracy of biopsy for the
preoperative diagnosis of superficial nonampullary duodenal
adenocarcinoma. Gastrointest Endosc 2017;86:329-332.
Kishikawa H, Kimura K, Ito A, Arahata K, Takarabe S, Kaida S, Kanai T,
Miura S, Nishida J. Correction: Association between Increased Gastric JuiceAcidity and Sliding Hiatal Hernia Development in Humans. PLoS One
2017;12:e0172375.
Kishikawa H, Kimura K, Ito A, Arahata K, Takarabe S, Kaida S, Kanai T,
Miura S, Nishida J. Association between Increased Gastric Juice Acidity andSliding Hiatal Hernia Development in Humans. PLoS One
2017;12:e0170416.
Kishikawa H, Kimura K, Ito A, Arahata K, Takarabe S, Kaida S, Miyauchi J,
Miura S, Kanai T, Nishida J. Cutoff Pepsinogen Level for Predicting
Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects
with Seemingly Normal Pepsinogen Levels. Digestion 2017;95:229-236.
Kitamura K, Horibe M, Sanui M, Sasaki M, Yamamiya A, Ishii Y, Yoshida H,Sawano H, Goto T, Ikeura T, Hamada T, Oda T, Yasuda H, Ogura Y,Miyazaki D, Hirose K, Chiba N, Ozaki T, Yamashita T, Koinuma T, Oshima
T, Yamamoto T, Hirota M, Azumi Y, Nagata K, Saito N, Sato M, Miyamoto K,

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Iwasaki E, Kanai T, Mayumi T. The Prognosis of Severe Acute Pancreatitis
Varies According to the Segment Presenting With Low Enhanced Pancreatic
Parenchyma on Early Contrast-Enhanced Computed Tomography: AMulticenter Cohort Study. Pancreas 2017;46:867-873.
Matsushita M, Nakatake Y, Arai I, Ibata K, Kohda K, Goparaju SK,
Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SBH, Kanai T, Yuzaki
M, Ko MSH. Neural differentiation of human embryonic stem cells inducedby the transgene-mediated overexpression of single transcription factors.
Biochem Biophys Res Commun 2017;490:296-301.
Minami K, Iwasaki E, Itoi T, Hibi T, Kanai T. Successful EUS-guided
nondilated pancreatic duct stent placement in patient with refractorypancreatic fistula after pancreaticoduodenectomy. VideoGIE 2017;2:315-316.
Miyamoto K, Horibe M, Sanui M, Sasaki M, Sugiyama D, Kato S, Yamashita
T, Goto T, Iwasaki E, Shirai K, Oe K, Sawano H, Oda T, Yasuda H, Ogura Y,
Hirose K, Kitamura K, Chiba N, Ozaki T, Oshima T, Yamamoto T, Nagata K,
Mine T, Saito K, Sekino M, Furuya T, Matsuda N, Hayakawa M, Kanai T,Mayumi T. Plasmapheresis therapy has no triglyceride-lowering effect inpatients with hypertriglyceridemic pancreatitis. Intensive Care Med
2017;43:949-951.
Mizukami T, Sugimoto S, Masaoka T, Suzuki H, Kanai T. Colonicdysmotility and morphological abnormality frequently detected in Japanesepatients with irritable bowel syndrome. Intest Res 2017;15:236-243.
Mizuki A, Tatemichi M, Nakazawa A, Tsukada N, Nagata H, Kanai T.
Changes in the Clinical Features and Long-term Outcomes of ColonicDiverticulitis in Japanese Patients. Intern Med 2017;56:2971-2977.
Mizuno S, Kanai T. Fecal microbiota transplantation. Nihon Rinsho
2017;75:492-497.
Mizuno S, Masaoka T, Naganuma M, Kishimoto T, Kitazawa M, Kurokawa S,Nakashima M, Takeshita K, Suda W, Mimura M, Hattori M, Kanai T.
Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful
Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome.
Digestion 2017;96:29-38.
Mizuno S, Nanki K, Matsuoka K, Saigusa K, Ono K, Arai M, Sugimoto S,Kiyohara H, Nakashima M, Takeshita K, Naganuma M, Suda W, Hattori M,Kanai T. Single fecal microbiota transplantation failed to change intestinal
microbiota and had limited effectiveness against ulcerative colitis inJapanese patients. Intest Res 2017;15:68-74.
Mizuno S, Wakui M, Machida Y, Hosoe N, Hisamatsu T, Ishida T,Kameyama K, Naganuma M, Kanai T. Increased levels of prostaglandin
E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis
patients: A case report. Medicine (Baltimore) 2017;96:e9237.
Mori H, Suzuki H, Matsuzaki J, Masaoka T, Kanai T. Antibiotic resistanceand gyrA mutation affect the efficacy of 10-day
sitafloxacin-metronidazole-esomeprazole therapy for Helicobacter pylori inpenicillin allergic patients. United European Gastroenterol J
2017;5:796-804.
Mori H, Suzuki H, Matsuzaki J, Taniguchi K, Shimizu T, Yamane T,
Masaoka T, Kanai T. Gender Difference of Gastric Emptying in Healthy
Volunteers and Patients with Functional Dyspepsia. Digestion

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2017;95:72-78.
Naganuma M, Hosoe N, Nakazato Y, Ogata H, Kanai T. Reply to Gheorghe
et al. Endoscopy 2017;49:1286.
Naganuma M, Kanai T. Endoscopy for inflammatory bowel disese. NihonRinsho 2017;75:380-385.
Naganuma M, Okuda S, Hisamatsu T, Matsuoka K, Mori K, Hosoe N,Nakazato Y, Ogata H, Kanai T. Findings of ulceration and severe stricture
on MRE can predict prognosis of Crohn's disease in patients treated with
anti-TNF treatment. Abdom Radiol (NY) 2017;42:141-151.
Naganuma M, Yahagi N, Bessho R, Ohno K, Arai M, Mutaguchi M, Mizuno
S, Fujimoto A, Uraoka T, Shimoda M, Hosoe N, Ogata H, Kanai T.
Evaluation of the severity of ulcerative colitis using endoscopic dual red
imaging targeting deep vessels. Endosc Int Open 2017;5:E76-e82.
Nakamoto N, Amiya T, Aoki R, Taniki N, Koda Y, Miyamoto K, Teratani T,
Suzuki T, Chiba S, Chu PS, Hayashi A, Yamaguchi A, Shiba S, Miyake R,
Katayama T, Suda W, Mikami Y, Kamada N, Ebinuma H, Saito H, Hattori
M, Kanai T. Commensal Lactobacillus Controls Immune Tolerance during
Acute Liver Injury in Mice. Cell Rep 2017;21:1215-1226.
Nakase H, Motoya S, Matsumoto T, Watanabe K, Hisamatsu T, Yoshimura
N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y,Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T. Significance ofmeasurement of serum trough level and anti-drug antibody of adalimumabas personalised pharmacokinetics in patients with Crohn's disease: asubanalysis of the DIAMOND trial. Aliment Pharmacol Ther
2017;46:873-882.
Nakazato Y, Naganuma M, Sugimoto S, Bessho R, Arai M, Kiyohara H, OnoK, Nanki K, Mutaguchi M, Mizuno S, Kobayashi T, Hosoe N, Shimoda M,Abe T, Inoue N, Ogata H, Iwao Y, Kanai T. Endocytoscopy can be used toassess histological healing in ulcerative colitis. Endoscopy 2017;49:560-563.
Nishizawa T, Ochiai Y, Uraoka T, Akimoto T, Mitsunaga Y, Goto O,Fujimoto A, Maehata T, Kanai T, Yahagi N. Endoscopic slip-knot clip
suturing method: prospective pilot study (with video). Gastrointest Endosc
2017;85:433-437.
Nishizawa T, Suzuki H, Fujimoto A, Kinoshita H, Yoshida S, Isomura Y,Toyoshima A, Kanai T, Yahagi N, Toyoshima O. Effects of patient age andchoice of antisecretory agent on success of eradication therapy for
Helicobacter pylori infection. J Clin Biochem Nutr 2017;60:208-210.
Nishizawa T, Suzuki H, Goto O, Ogata H, Kanai T, Yahagi N. Effect ofprophylactic clipping in colorectal endoscopic resection: A meta-analysis ofrandomized controlled studies. United European Gastroenterol J
2017;5:859-867.
Nishizawa T, Suzuki H, Hosoe N, Ogata H, Kanai T, Yahagi N.
Dexmedetomidine vs propofol for gastrointestinal endoscopy: Ameta-analysis. United European Gastroenterol J 2017;5:1037-1045.
Nishizawa T, Suzuki H, Sakitani K, Yamashita H, Yoshida S, Hata K,Kanazawa T, Fujiwara N, Kanai T, Yahagi N, Toyoshima O. Family history
is an independent risk factor for the progression of gastric atrophy among
patients with Helicobacter pylori infection. United European Gastroenterol J2017;5:32-36.

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Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S,
Sugimoto S, Kanai T, Sato T. Visualization and targeting of LGR5(+) humancolon cancer stem cells. Nature 2017;545:187-192.
Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N,Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T.
Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healingin Ulcerative Colitis. J Crohns Colitis 2017;11:84-91.
Sugimoto S, Naganuma M, Iwao Y, Matsuoka K, Shimoda M, Mikami S,Mizuno S, Nakazato Y, Nanki K, Inoue N, Ogata H, Kanai T. Endoscopic
morphologic features of ulcerative colitis-associated dysplasia classified
according to the SCENIC consensus statement. Gastrointest Endosc
2017;85:639-646.e2.
Tanemoto S, Sujino T, Kanai T. [Intestinal immune response is regulated bygut microbe]. Nihon Rinsho Meneki Gakkai Kaishi 2017;40:408-415.
Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Hida S, Okada Y,Kurihara C, Ebinuma H, Nakamoto N, Saito H, Hibi T, Miura S, Hokari R,Kanai T. Free cholesterol accumulation in liver sinusoidal endothelial cells
exacerbates acetaminophen hepatotoxicity via TLR9 signaling. J Hepatol
2017;67:780-790.
Usui S, Ebinuma H, Chu PS, Nakamoto N, Yamagishi Y, Saito H, Kanai T.
Detection of bacterial DNA by in situ hybridization in patients withdecompensated liver cirrhosis. BMC Gastroenterol 2017;17:106.
Yamada S, Kamada N, Amiya T, Nakamoto N, Nakaoka T, Kimura M, Saito
Y, Ejima C, Kanai T, Saito H. Gut microbiota-mediated generation ofsaturated fatty acids elicits inflammation in the liver in murine high-fat
diet-induced steatohepatitis. BMC Gastroenterol 2017;17:136.