1. Akiyama S, Matsuoka K, Fukuda K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H,Arai M, Sugimoto S, Iwao Y, Ogata H, Hisamatsu T, Naganuma M, Motobayashi M, Suzuki K,
Takenaka K, Fujii T, Saito E, Nagahori M, Ohtsuka K, Mochizuki M, Watanabe M, Hashiguchi
M, Kanai T.
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease
patients treated with thiopurine.
J Gastroenterol Hepatol 2019;34:1751-1757.
2. Aoki Y, Hamamoto Y, Ugamura A, Togasaki K, Suzuki T, Kawasaki K, Hirata K, Kasuga A,Sukawa Y, Kanai T, Takaishi H.
Early administration of systemic chemotherapy should be considered for scirrhous gastric cancer:
A case report.
Mol Clin Oncol 2019;10:113-117.
3. Fukuda T, Naganuma M, Kanai T.
Current new challenges in the management of ulcerative colitis.
Intest Res 2019;17:36-44.
4. Fukuda T, Naganuma M, Kanai T.
How Can We Assess "Complete Healing" Beyond Endoscopic Remission?
Inflamm Bowel Dis 2019;25:e68.
5. Fukuda T, Naganuma M, Sugimoto S, Ono K, Nanki K, Mizuno S, Kimura K, Mutaguchi M,Nakazato Y, Takabayashi K, Inoue N, Ogata H, Iwao Y, Kanai T.
Efficacy of Therapeutic Intervention for Patients With an Ulcerative Colitis Mayo Endoscopic
Score of 1.
Inflamm Bowel Dis 2019;25:782-788.
6. Fukuhara S, Kato M, Iwasaki E, Sasaki M, Tsutsumi K, Kiguchi Y, Akimoto T, Takatori Y,Nakayama A, Maehata T, Minami K, Ogata H, Kanai T, Yahagi N.
Management of perforation related to endoscopic submucosal dissection for superficial duodenalepithelial tumors.
Gastrointest Endosc 2019.
7. Hagihara Y, Yoshimatsu Y, Mikami Y, Takada Y, Mizuno S, Kanai T.
Epigenetic regulation of T helper cells and intestinal pathogenicity.
Semin Immunopathol 2019;41:379-399.
8. Hayashi Y, Hosoe N, Takabayashi K, Kamiya KJL, Mutaguchi M, Miyanaga R, Hirata K,Fukuhara S, Mikami Y, Sujino T, Masugi Y, Naganuma M, Ogata H, Kanai T.
Clinical and Endoscopic Characteristics of Pyogenic Granuloma in the Small Intestine: A Case
Series with Literature Review.
Intern Med 2019.
9. Hisamatsu T, Kato S, Kunisaki R, Matsuura M, Nagahori M, Motoya S, Esaki M, Fukata N, InoueS, Sugaya T, Sakuraba H, Hirai F, Watanabe K, Kanai T, Naganuma M, Nakase H, Suzuki Y,Watanabe M, Hibi T, Nojima M, Matsumoto T.
Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: aprospective randomised clinical trial (DIAMOND2).
J Gastroenterol 2019;54:860-870.
10. Hisamatsu T, Matsumoto T, Watanabe K, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S,Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe
M, Hibi T.

Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance
Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised
Clinical Trial [DIAMOND Study].
J Crohns Colitis 2019;13:1097-1104.
11. Horibe M, Sanui M, Sasaki M, Honda H, Ogura Y, Namiki S, Sawano H, Goto T, Ikeura T, TakedaT, Oda T, Yasuda H, Miyazaki D, Hirose K, Kitamura K, Chiba N, Ozaki T, Yamashita T, Koinuma
T, Oshima T, Yamamoto T, Hirota M, Yamamoto S, Oe K, Ito T, Masuda Y, Saito N, Iwasaki E,Kanai T, Mayumi T.
Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development ofInvasive Candidiasis: A Large Retrospective Multicenter Cohort Study.
Pancreas 2019;48:537-543.
12. Horie T, Hosoe N, Takabayashi K, Hayashi Y, Kamiya KJL, Miyanaga R, Mizuno S, Fukuhara K,Fukuhara S, Naganuma M, Shimoda M, Ogata H, Kanai T.
Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted
enteroscopy.
World J Gastrointest Endosc 2019;11:373-382.
13. Hosoe N, Takabayashi K, Ogata H, Kanai T.
Capsule endoscopy for small-intestinal disorders: Current status.
Dig Endosc 2019;31:498-507.
14. Ichikawa M, Sujino T, Kanai T.
[The Relationship between Gut Microbiome, Immune System, and Cancer].
Gan To Kagaku Ryoho 2019;46:1807-1813.
15. Igaki K, Nakamura Y, Tanaka M, Mizuno S, Yoshimatsu Y, Komoike Y, Uga K, Shibata A, Imaichi
H, Takayuki S, Ishimura Y, Yamasaki M, Kanai T, Tsukimi Y, Tsuchimori N.
Pharmacological effects of TAK-828F: an orally available RORgammat inverse agonist, in mousecolitis model and human blood cells of inflammatory bowel disease.
Inflamm Res 2019;68:493-509.
16. Ji F, Yeo YH, Wei MT, Ogawa E, Enomoto M, Lee DH, Iio E, Lubel J, Wang W, Wei B, Ide T,Preda CM, Conti F, Minami T, Bielen R, Sezaki H, Barone M, Kolly P, Chu PS, Virlogeux V,Eurich D, Henry L, Bass MB, Kanai T, Dang S, Li Z, Dufour JF, Zoulim F, Andreone P, Cheung
RC, Tanaka Y, Furusyo N, Toyoda H, Tamori A, Nguyen MH.
Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C
and hepatocellular carcinoma: A systematic review and meta-analysis.
J Hepatol 2019;71:473-485.
17. Kashiwagi K, Minami K, Seino T, Hirata K, Iwasaki E, Inoue N, Iwao Y, Kanai T.
Pancreatic fat content may increase the risk of imaging progression in low-risk branch duct
intraductal papillary mucinous neoplasm.
J Dig Dis 2019;20:557-562.
18. Kashiwagi K, Seino T, Makino K, Shimizu-Hirota R, Takayama M, Yoshida T, Iwasaki E, Sugino
Y, Inoue N, Iwao Y, Kanai T.
Negative effect of fatty liver on visualization of pancreatic cystic lesions at screening
transabdominal ultrasonography.
J Eval Clin Pract 2019.
19. Kato M, Ochiai Y, Fukuhara S, Maehata T, Sasaki M, Kiguchi Y, Akimoto T, Fujimoto A,Nakayama A, Kanai T, Yahagi N.
Clinical impact of closure of the mucosal defect after duodenal endoscopic submucosal dissection.
Gastrointest Endosc 2019;89:87-93.
20. Kato M, Sasaki M, Mizutani M, Tsutsumi K, Kiguchi Y, Akimoto T, Mutaguchi M, Nakayama A,

Takabayashi K, Fujimoto A, Ochiai Y, Maehata T, Kanai T, Yahagi N.
Predictors of technical difficulty with duodenal ESD.
Endosc Int Open 2019;7:E1755-e1760.
21. Kawasaki K, Fujii M, Sugimoto S, Ishikawa K, Matano M, Ohta Y, Toshimitsu K, Takahashi S,
Hosoe N, Sekine S, Kanai T, Sato T.
Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional
Serrated Adenoma.
Gastroenterology 2019.
22. Kiguchi Y, Kato M, Nakayama A, Sasaki M, Mizutani M, Tsutsumi K, Akimoto T, Takatori Y,Mutaguchi M, Takabayashi K, Ochiai Y, Maehata T, Kanai T, Yahagi N.
Feasibility study comparing underwater endoscopic mucosal resection and conventional
endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumor < 20 mm.
Dig Endosc 2019.
23. Kikuchi T, Arai M, Koda Y, Kato J, Shimizu T, Katano H, Fujii-Nishimura Y, Sakamoto M,Ebinuma H, Nakamoto N, Kanai T, Okamoto S, Mori T.
Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic
hematopoietic stem cell transplantation.
Transpl Infect Dis 2019;21:e13121.
24. Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai MM, Nomura E, Harada Y, Aoki R, Koda Y,Mikami Y, Mizuno S, Naganuma M, Hisamatsu T, Kanai T.
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitisby Altering the Gut Microbiome and Immune Cells.
Cell Mol Gastroenterol Hepatol 2019;7:135-156.
25. Koda Y, Nakamoto N, Chu PS, Ugamura A, Mikami Y, Teratani T, Tsujikawa H, Shiba S, Taniki
N, Sujino T, Miyamoto K, Suzuki T, Yamaguchi A, Morikawa R, Sato K, Sakamoto M, Yoshimoto
T, Kanai T.
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
J Clin Invest 2019;129:3201-3213.
26. Komatsu A, Yoshino T, Suzuki T, Nakamura T, Kanai T, Watanabe K.
Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A
retrospective cohort study.
Basic Clin Pharmacol Toxicol 2019;124:607-614.
27. Masaoka T, Kanai T.
[Current knowledge of irritable bowel syndrome -treatment].
Nihon Shokakibyo Gakkai Zasshi 2019;116:570-575.
28. Matsuzaki J, Suzuki H, Shimoda M, Mori H, Fukuhara S, Miyoshi S, Masaoka T, Iwao Y, Kanai
Y, Kanai T.
Clinical and endoscopic findings to assist the early detection of duodenal adenoma andadenocarcinoma.
United European Gastroenterol J 2019;7:250-260.
29. Matsuzaki J, Tsugawa H, Kashiwazaki Y, Mori H, Yamamoto Y, Kameyama H, Masaoka T, KanaiT, Suzuki H.
Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk ofDyspepsia.
Cell Mol Gastroenterol Hepatol 2019;8:295-297.e6.
30. Minami K, Horibe M, Sanui M, Sasaki M, Iwasaki E, Sawano H, Goto T, Ikeura T, Takeda T, OdaT, Yasuda H, Ogura Y, Miyazaki D, Kitamura K, Chiba N, Ozaki T, Yamashita T, Koinuma T,Oshima T, Yamamoto T, Hirota M, Tokuhira N, Azumi Y, Nagata K, Takeda K, Furuya T, Lefor

AK, Mayumi T, Kanai T.
The Effect of an Invasive Strategy for Treating Pancreatic Necrosis on Mortality: a Retrospective
Multicenter Cohort Study.
J Gastrointest Surg 2019.
31. Minami K, Iwasaki E, Fukuhara S, Horibe M, Seino T, Kawasaki S, Katayama T, Takimoto Y,Tamagawa H, Machida Y, Kanai T, Itoi T.
Electric Endocut and Autocut Resection for Endoscopic Papillectomy: A Systematic Review.
Intern Med 2019;58:2767-2772.
32. Minami K, Iwasaki E, Kawasaki S, Fukuhara S, Seino T, Katayama T, Takimoto Y, Tamagawa H,Machida Y, Horibe M, Kitago M, Ogata H, Kanai T.
A long (7 cm) prophylactic pancreatic stent decreases incidence of post-endoscopic papillectomy
pancreatitis: a retrospective study.
Endosc Int Open 2019;7:E1663-e1670.
33. Mizuno S, Naganuma M, Kanai T.
Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease.
Inflamm Bowel Dis 2019;25:e26.
34. Mori H, Suzuki H, Matsuzaki J, Masaoka T, Kanai T.
10-Year Trends in Helicobacter pylori Eradication Rates by Sitafloxacin-Based Third-Line RescueTherapy.
Digestion 2019:1-7.
35. Motoya S, Watanabe K, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K,
Hori T, Araki T, Watanabe M, Hibi T.
Correction: Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized,
double-blind, placebo-controlled study.
PLoS One 2019;14:e0215491.
36. Motoya S, Watanabe K, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K,
Hori T, Araki T, Watanabe M, Hibi T.
Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind,placebo-controlled study.
PLoS One 2019;14:e0212989.
37. Mutaguchi M, Naganuma M, Sugimoto S, Fukuda T, Nanki K, Mizuno S, Hosoe N, Shimoda M,
Ogata H, Iwao Y, Kanai T.
Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic
neoplasia in ulcerative colitis patients.
Dig Liver Dis 2019;51:1257-1264.
38. Naganuma M, Hirai F, Kobayashi K, Watanabe K, Takeuchi K, Aoyama N, Nozawa H, Motoya S,Ohmori T, Harada A, Nagai Y, Abe T, Yamada Y, Inagaki K, Shimizu N, Kanai T, Watanabe M.
Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic
remission by budesonide rectal foam.
PLoS One 2019;14:e0220413.
39. Naganuma M, Kobayashi T, Nasuno M, Motoya S, Kato S, Matsuoka K, Hokari R, Watanabe C,
Sakamoto H, Yamamoto H, Sasaki M, Watanabe K, Iijima H, Endo Y, Ichikawa H, Ozeki K,Tanida S, Ueno N, Fujiya M, Sako M, Takeuchi K, Sugimoto S, Abe T, Hibi T, Suzuki Y, Kanai T.
Significance of Conducting 2 Types of Fecal Tests in Patients with Ulcerative Colitis.
Clin Gastroenterol Hepatol 2019.
40. Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka
S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K,Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T.

Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc
analysis from the INDIGO study.
J Gastroenterol 2019.
41. Naganuma M, Sugimoto S, Suzuki H, Matsuno Y, Araki T, Shimizu H, Hayashi R, Fukuda T,Nakamoto N, Iijima H, Nakamura S, Kataoka M, Tamura Y, Tatsumi K, Hibi T, Suzuki Y, KanaiT.
Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanesenationwide survey.
J Gastroenterol 2019;54:891-896.
42. Naganuma M, Yokoyama Y, Motoya S, Watanabe K, Sawada K, Hirai F, Yamamoto T, Hanai H,Omori T, Kanai T, Hibi T.
Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label
prospective multicenter randomised controlled trial.
J Gastroenterol 2019.
43. Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS,
Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K,Narushima S, Yoshimura A, Honda K, Sato T, Kanai T.
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response
in primary sclerosing cholangitis.
Nat Microbiol 2019;4:492-503.
44. Nakayama A, Kato M, Takatori Y, Shimoda M, Mizutani M, Tsutsumi K, Kiguchi Y, Akimoto T,
Sasaki M, Mutaguchi M, Takabayashi K, Maehata T, Ochiai Y, Kanai T, Yahagi N.
How I do it: Endoscopic diagnosis for superficial non-ampullary duodenal epithelial tumors.
Dig Endosc 2019.
45. Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii
E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T.
Erratum: Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing inUlcerative Colitis.
J Crohns Colitis 2019;13:1590.
46. Sugimoto S, Shimoda M, Iwao Y, Mutaguchi M, Nanki K, Mizuno S, Kameyama K, Ogata H,Naganuma M, Kanai T.
Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative
colitis-associated high-grade dysplasia.
Dig Endosc 2019;31:706-711.
47. Suzuki T, Sukawa Y, Imamura CK, Masuishi T, Satake H, Kumekawa Y, Funakoshi S, Kotaka M,Horie Y, Kawai S, Okuda H, Terazawa T, Kondoh C, Kato K, Yoshimura K, Ishikawa H,Hamamoto Y, Boku N, Takaishi H, Kanai T.
A Phase II Study of Regorafenib With a Lower Starting Dose in Patients With Metastatic
Colorectal Cancer: Exposure-Toxicity Analysis of Unbound Regorafenib and Its Active
Metabolites (RESET Trial).
Clin Colorectal Cancer 2019.
48. Takabayashi K, Hosoe N, Kato M, Hayashi Y, Miyanaga R, Nanki K, Fukuhara K, Mikami Y,Mizuno S, Sujino T, Mutaguchi M, Naganuma M, Yahagi N, Ogata H, Kanai T.
Efficacy of Novel Ultrathin Single-Balloon Enteroscopy for Crohn's Disease: A Propensity ScoreMatched Study.
Gut Liver 2019.
49. Takabayashi K, Hosoe N, Miyanaga R, Fukuhara S, Kimura K, Mizuno S, Naganuma M, Yahagi
N, Ogata H, Kanai T. Correction: Clinical utility of novel ultrathin single-balloon enteroscopy: afeasibility study.

Endoscopy 2019;51:C2.
50. Takabayashi K, Hosoe N, Miyanaga R, Fukuhara S, Kimura K, Mizuno S, Naganuma M, Yahagi
N, Ogata H, Kanai T.
Clinical utility of novel ultrathin single-balloon enteroscopy: a feasibility study.
Endoscopy 2019;51:468-471.
51. Takimoto Y, Iwasaki E, Masaoka T, Fukuhara S, Kawasaki S, Seino T, Katayama T, Minami K,Tamagawa H, Machida Y, Ogata H, Kanai T.
Novel mainstream capnometer system is safe and feasible even under CO2 insufflation during
ERCP-related procedure: a pilot study.
BMJ Open Gastroenterol 2019;6:e000266.
52. Wada M, Nishizawa T, Kato M, Hirai Y, Kinoshita S, Mori H, Nakazato Y, Fujimoto A, Kikuchi
M, Uraoka T, Kanai T.
Colonic diverticular bleeding and predictors of the length of hospitalization: An observational
study.
J Gastroenterol Hepatol 2019;34:1351-1356.
53. Watanabe K, Motoya S, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K,
Hori T, Araki T, Watanabe M, Hibi T.
Effects of vedolizumab in Japanese patients with Crohn's disease: a prospective, multicenter,randomized, placebo-controlled Phase 3 trial with exploratory analyses.
J Gastroenterol 2019.
54. Yamashita T, Horibe M, Sanui M, Sasaki M, Sawano H, Goto T, Ikeura T, Hamada T, Oda T,Yasuda H, Ogura Y, Miyazaki D, Hirose K, Kitamura K, Chiba N, Ozaki T, Koinuma T, Oshima
T, Yamamoto T, Hirota M, Masuda Y, Tokuhira N, Kobayashi M, Saito S, Izai J, Lefor AK, Iwasaki
E, Kanai T, Mayumi T.
Large Volume Fluid Resuscitation for Severe Acute Pancreatitis is Associated With Reduced
Mortality: A Multicenter Retrospective Study.
J Clin Gastroenterol 2019;53:385-391.
55. Yoshimatsu Y, Naganuma M, Sugimoto S, Tanemoto S, Umeda S, Fukuda T, Nomura E, Yoshida
K, Ono K, Mutaguchi M, Nanki K, Mizuno S, Mikami Y, Fukuhara K, Sujino T, Takabayashi K,Ogata H, Iwao Y, Kanai T.
Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients withUlcerative Colitis.
Digestion 2019:1-7.