SAFETY DATA SHEETSECTION 1: PRODUCT AND COMPANY INFORMATION
Product name:​ Component A
Contact:
Elixirgen Scientific, Inc.
855 N. Wolfe St., Suite 631
Baltimore, MD 21205
Phone: +1 443-869-5420
https://elixirgensci.com
SECTION 2: HAZARD IDENTIFICATIONGHS classification of the substance or mixture:
GHS Classification in accordance with 29 CFT 1910 (OSHA HCS)
Flammable liquids (Category 4), H227
Acute toxicity, Dermal (Category 4), H312
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute aquatic toxicity (Category 2), H401
For full text of the H-Statements mentioned in this Section, see Section16.
GHS label elements, including precautionary statements:
Hazard picograms:

Signal word:

Warning

Hazard Statement(s):H227
H302 + H312 + H332
H401 Toxic to aquatic life.

Combustible liquid.
Harmful if swallowed, in contact with skin or if inhaled.

Precautionary statements:
P210
P261
P264
P270
P271

Keep away from heat/sparks/open flames/hot
surfaces. No smoking.
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wash skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
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P273
P280

Avoid release to the environment.
Wear protective gloves/protective clothing/eye
protection/face protection.
IF SWALLOWED: Call a POISON CENTER ordoctor/physician if you feel unwell.
IF ON SKIN: Wash with plenty of soap and water.
IF INHALED: Remove patient to fresh air and keep at restin a position comfortable for breathing.
Specific measures (see supplemental first aid instructions
on this label.)
Rinse mouth.
Wash contaminated clothing before reuse.
In case of fire: Use dry sand, dry chemical or
alcohol-resistant foam for extinction.
Store in a well-ventilated place. Keep cool.
Dispose of contents/container to an approved waste
disposal plant.

P301+P312
P302+P352
P304+P340
P322
P330
P363
P370+P378
P403+P235
P501

Other hazards which do not result in the classification or are not covered by the GHS:
None.
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS​ ​SUBSTANCE
Substance/Mixture:

MixtureHazardous Ingredients
Chemical Name CAS-No.
Dimethyl67-68-5
sulfoxide
Colforsin
66575-29-9Dorsomorphin
866405-64-3
Tretinoin
302-79-4

GHS-US Hazardous Calssification
Flam. Liq. 4; H227

Concentration (%)<=100

Acute Tox. 4; H312
Acute Tox. 4; H302+H312+H332
Acute Tox. 4; Aquatic Acute 2;
H302, H401

<0.1
<0.1
0.2

For the full text of the H-statements mentioned in this Section, see Section 16.
SECTION 4: FIRST AID MEASURES
Description of first aid measure
General advice: Consult a physician. Show this safety data sheet to the doctor inattendance. Move out of dangerous area.
Inhalation:
If inhaled in, move person into fresh air. If not breathing, give artificialrespiration. Consult a physician.
2Skin contact:
Eye contact:
Ingestion:

Wash off with soap and plenty of water. Consult a physician.
Flush eyes with water as a precaution.
Never give anything by mouth to an unconscious person. Rinse mouthwith water. Consult a physician.

Most important symptoms/effects, acute and delayed.
The most important known symptoms and effects are described in the labelling (see section2.2) and/or in section 11.
Indication of immediate medical attention and special treatment needed.
No data available.
SECTION 5: FIRE-FIGHTING MEASURES
Suitable extinguishing media:
For small (incipient) fires, use media such as “alcohol” foam, dry chemical, or carbon
dioxide. For large fires, apply water from as far as possible. Use very large quantities(flooding) of water applied as a mist or spray; solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.
Specific hazards arising from the substance or mixture:
Carbon oxides, Sulphur oxides, and nitrogen oxides (NOx).
Advice for fire-fighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Further information:
Use water spray to cool unopened containers.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures:
Avoid dust formation. Avoid breathing vapors, mist, gas, or dust. Remove all sources ofignition. Beware of vapors accumulating to form explosive concentrations. Vapors canaccumulate in low areas. For personal protection use safety glasses, lab coat, and gloves.
Remove all sources of ignition. Remove persons to safety.
Environmental precautions:
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Contain spillage, and then collect with an electrically protected vacuum cleaner or by
wet-brushing and place in container for disposal according to local regulations (see section3

13). Keep in suitable, closed containers for disposal.
Reference to other section:
For disposal see section 13.
SECTION 7: HANDLING AND STORAGE
Precautions for safe handling:
Avoid contact with skin and eyes, inhalation of vapors, and mists. Avoid formation of dust
and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Keep away from sources of ignition – No smoking. Take measures to prevent the build upof electrostatic charge. For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Store under inert gas. Hygroscopic. Light sensitive.
Specific end use(s):Apart from the uses mentioned in section 1.2, no other specific uses are stipulated.
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters:
Ingredient

CAS No.

Dimethylsulfoxide

67-68-5

Value type(Form ofexposure)
TWA

Controlparameters/Permissibl
e concentration
250.000000 ppm

BasisUSA. Workplace
Environmental Exposure
Levels (WEEL)

Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
Personal protective equipment:
Eyes:
Body:
Skin:

Safety goggles or splash guard safety glasses.
Lab coat and gloves.
Handle with gloves. Gloves must be inspected prior to use. Useproper glove removal technique (without touching glove’s outersurface) to avoid skin contact with this product. Dispose ofcontaminated gloves after use in accordance with applicable laws
and good laboratory practices. Wash and dry hands.
4Respiratory:

Where risk assessment shows air-purifying respirators areappropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges
as a backup to engineering controls. If the respirator is the solemeans of protection, use a full-face supplied air respirator. Userespirators and components tested and approved under appropriate
government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure:
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance:
Odor:
Odor threshold:pH:
Melting point/freezing point:
Initial boiling point and boiling range:
Flash point:
Evaporation rate:
Flammability (solid, gas):
Upper/lower flammability or explosive limits:
Vapor pressure:
Vapor density:
Relative density:
Solubility(ies):
Partition coefficient: n-octanol/water:
Auto-ignition temperature:
Decomposition temperature:
Viscosity:
Explosive properties:
Oxidizing properties:

Aqueous solution.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.

SECTION 10: STABILITY AND REACTIVITY
Reactivity:
Chemical stability:
Possibility of hazardous reactions:
Conditions to avoid:
Incompatible materials:

No data available.
Stable under recommended storage conditions.
No data available.
Heat, light, flames and sparks.
Acid chlorides, Phosphorus halides, Strong acids, Strongbases, Oxidizing agents, Strong reducing agents.
Hazardous decomposition products: Other decomposition products - No data available.
In the event of fire: see section 55

SECTION 11: TOXICOLOGICAL INFORMATION
Acute toxicity:
Chemical NameDimethyl sulfoxide
Colforsin
Tretinoin

LD50 (oral,rat/mouse)= 14,500 mg/kg(Rat)= 2,550 mg/kg (Rat)= 2,000 mg/kg (Rat)

LD50 (dermal,rat/rabbit)>5,000 mg/kg(Rabbit)no data available
2,500 mg/kg(Rabbit)

LC50 (inhalation,rat/mouse)
40250 ppm 4h (Rat)no data available
no data available

Skin corrosion/irritation: ​No data available.
Serious eye damage/eye irritation:
Tretinoin
Eyes - rabbit
Result: No eye irritation
Respiratory or skin sensitization:​ No data available.
Mutagenicity:
Tretinoin
NegativeCarcinogenicity:
Dimethyl sulfoxide
Rat – Oral
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages:
Other: Tumors.
Mouse – Oral
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria. Leukemia Skin andAppendages: Other: Tumors.\IARC:

No component of this product present at levels greater than or equal to 0.1% isidentified as probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% isidentified as probable, possible or confirmed human carcinogen by ACGIH.
NTP:
No component of this product present at levels greater than or equal to 0.1% isidentified as probable, possible or confirmed human carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% isidentified as probable, possible or confirmed human carcinogen by OSHA.
Reproductive toxicity:
Dimethyl sulfoxide
Rat – Intraperitoneal
Effects on Fertility:

Abortion.
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Rat – Intraperitoneal
Effects on Fertility:
Rat – Subcutaneous
Effects on Fertility:

Mouse – OralEffects on Fertility:
Effects on Embryo or Fetus:

Post-implantation mortality (e.g., dead and/or resorbed
implants per total number of implants).
Post-implantation mortality (e.g., dead and/or resorbed
implants per total number of implants). Litter size (e.g.,#fetuses per litter; measured before birth).
Pre-implantation mortality (e.g., reduction in number ofimplants per female; total number of implants per corpora
lutea).
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Musculoskeletal system.

Specific target organ toxicity:
No data available.
Aspiration hazard:
No data available.
Additional Information:
Dimethyl sulfoxide
RTECS: PV6210000
Effects due to ingestion may include: Nausea, Fatigue, Headache
Tretinoin
RTECS: VH6475000
To the best of our knowledge, the chemical physical, and toxicological properties have notbeen thoroughly investigated.
SECTION 12: ECOLOGICAL INFORMATION
Toxicity:
Dimethyl sulfoxide
Toxicity to fish:
LC50 – Pimephales promelas (fathead minnow) – 34,000 mg/l – 96h
LC50 – Oncorhynchus mykiss (rainbow trout) – 35,000 mg/l – 96h
Toxicity to daphnia and other aquatic invertebrates:
EC50 – Daphnia magna (Water flea) – 24,600 mg/l – 48h7

(OECD Test Guideline 202)
Toxicity to algae:
Duration 48h – mg/l: 9268
Tretinoin
LC50 - Danio rerio (zebra fish) - 4.64 mg/l - 96 h
Persistence and degradability:
Dimethyl sulfoxide
Result: 31% - According to the results of tests of biodegradability this product is notreadily biodegradable.
(OECD Test Guideline 301D)
Tretinoin
Result: > 60 % - Readily biodegradable.
Bioaccumulative potential:
TretinoinDoes not bioaccumulate.
Mobility in soil:
No data available.
Results of PBT and vPvB assessment:
PBT/vPvB assessmenrt not available as chemical safety assessment not required/notconducted.
Other adverse effects:
An environmental hazard cannot be excluded in the event of unprofessional handling ordisposal. Toxic to aquatic life.
no data available
SECTION 13: DISPOSAL INFORMATION
Waste treatment methods:
ProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact alicensed professional waste disposal service to dispose of this material. Dissolve or mix thematerial with a combustible solvent and burn in a chemical incinerator equipped with anafterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
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SECTION 14: TRANSPORT INFORMATION
DOT (US)NA-Number: 1993
Class: None
Packaging group: III
Proper shipping name: Combustible liquid, n.o.s. (Dimethyl sulfoxide)
IMDG
UN number: 3077 Class: 9 Packing group: III EMS-No: F-A, S-F
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S .
(Tretinoin)
Marine pollutant: Marine pollutant
IATAUN number: 3077 Class: 9 Packing group: III
Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Tretinoin)
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings andcombination packagings containing inner packagings with Dangerous Goods > 5L for liquids or> 5kg for solids.
SECTION 15: REGULATORY INFORMATIONSARA 302 Components
No chemicals in this material are subject to the reporting requirements of SARA Title III,Section 302.
SARA 313 Components
This material does not contain any chemical components with known CAS numbers that exceed
the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard.
US State regulations:
Massachusetts Right To know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
4-(5-Benzol[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide hydrate

CAS-No96-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Colforsin
Dimethyl sulfoxide
Tretinoin

866405-64-3
66575-29-9
67-68-5
302-79-4

New Jersey Right To Know Components
CAS-No4-(5-Benzol[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide hydrate 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
866405-64-3
Colforsin
66575-29-9
Dimethyl sulfoxide
67-68-5
Tretinoin
302-79-4
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birthdefects, or any other reproductive harm.
SECTION 16: OTHER INFORMATION
Full text of H-Statements referred to under sections 2 and 3
6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Acute Tox.
Acute toxicity
H302
Harmful if swallowed.
H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled.
H312
Harmful in contact with skin.
Colforsin
Acute Tox.
H312

Acute toxicity
Harmful in contact with skin.

Dimethyl sulfoxide
Flam. Liq.
H227

Flammable liquids.
Combustible liquid.

Tretinoin
Acute Tox.
Aquatic AcuteH302
H401

Acute toxicity
Acute aquatic toxicity
Harmful if swallowed.
Toxic to aquatic life.
10HMIS Rating
4-(5-Benzol[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide hydrate
Health hazard:
0
Chronic Health Hazard:
Flammability:0
Physical Hazard:
0
6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Health hazard:
2
Chronic Health Hazard:
Flammability:0
Physical Hazard:
0
Colforsin
Health hazard:
Chronic Health Hazard:
Flammability:
Physical Hazard:
Dimethyl sulfoxide
Health hazard:
Chronic Health Hazard:
Flammability:
Physical Hazard:
Tretinoin
Health hazard:
Chronic Health Hazard:
Flammability:
Physical Hazard

100020100

NFPA Rating
4-(5-Benzol[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide hydrate
Health hazard:
0Fire Hazard:
0
Reactivity Hazard:
06-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Health hazard:
2Fire Hazard:
0
Reactivity Hazard:
011Colforsin
Health hazard:
Fire Hazard:
Reactivity Hazard:

100Dimethyl sulfoxide
Health hazard:
Fire Hazard:
Reactivity Hazard:

020Tretinoin
Health hazard:
Fire Hazard:
Reactivity Hazard:

000

Other comments:
The information provided herein is based on sources believed to be reliable as of 9/18/2018 andpertains only to the material designated. Elixirgen Scientific, Inc. makes no warranty orrepresentation to its completeness, accuracy, or currency, and assumes no liability resulting fromits use. This material is intended for use by persons with pertinent technical skills for its
intended use, the product’s safe use, and the product’s proper disposal. Disposal of hazardous
material may be subjected to federal, state or local laws or regulations.
Restriction of use:For research use only.

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