1. Fukuda T, Naganuma M, Kanai T.
[Treatment strategy for inflammatory bowel disease with a focus on biologicals].
Nihon Shokakibyo Gakkai Zasshi 2018;115:272-282.
2. Hamamoto Y, Shin N, Hoshino T, Kanai T.
Management of challenging immune-related gastrointestinal adverse events associated withimmune checkpoint inhibitors.
Future Oncol 2018;14:3187-3198.
3. Hisamatsu T, Kunisaki R, Nakamura S, Tsujikawa T, Hirai F, Nakase H, Watanabe K, YokoyamaK, Nagahori M, Kanai T, Naganuma M, Michimae H, Andoh A, Yamada A, Yokoyama T, Kamata
N, Tanaka S, Suzuki Y, Hibi T, Watanabe M.
Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease
with loss of response to infliximab: CERISIER trial.
Intest Res 2018;16:494-498.
4. Honjo M, Itoi T, Tsuchiya T, Tanaka R, Tonozuka R, Mukai S, Sofuni A, Nagakawa Y, Iwasaki H,Kanai T.
Safety and efficacy of ultra-tapered mechanical dilator for EUS-guided hepaticogastrostomy andpancreatic duct drainage compared with electrocautery dilator (with video).
Endosc Ultrasound 2018;7:376-382.
5. Horibe M, Ogura Y, Matsuzaki J, Kaneko T, Yokota T, Okawa O, Nakatani Y, Iwasaki E, Nishizawa
T, Hosoe N, Masaoka T, Yahagi N, Namiki S, Kanai T.
Absence of high-risk stigmata predicts good prognosis even in severely anemic patients withsuspected acute upper gastrointestinal bleeding.
United European Gastroenterol J 2018;6:684-690.
6. Hosoe N, Nakano M, Takeuchi K, Endo Y, Matsuoka K, Abe T, Omori T, Hayashida M, Kobayashi
T, Yoshida A, Mizuno S, Nakazato Y, Naganuma M, Kanai T, Watanabe M, Ueno F, Suzuki Y, HibiT, Ogata H.
Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of
Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis.
Inflamm Bowel Dis 2018;24:2641-2647.
7. Hosoe N, Ogata H, Kanai T.
[Review of the small intestinal mucosal lesion].
Nihon Shokakibyo Gakkai Zasshi 2018;115:605-611.
8. Hosoe N, Ohtsuka K, Endo Y, Naganuma M, Ogata N, Kuroki Y, Sasanuma S, Takabayashi K,Kudo SE, Takahashi H, Ogata H, Kanai T.
Insertability comparison of passive bending single-balloon prototype versus standard singleballoon enteroscopy: a multicenter randomized non-blinded trial.
Endosc Int Open 2018;6:E1184-e1189.
9. Ishigaki S, Masaoka T, Kameyama H, Kawaida M, Kameyama K, Mori T, Kanai T.
Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosaassociated Lymphoid Tissue Lymphoma.
Intern Med 2018;57:3249-3254.
10. Kashiwagi K, Seino T, Fukuhara S, Minami K, Horibe M, Iwasaki E, Takaishi H, Itoh K, Sugino
Y, Inoue N, Iwao Y, Kanai T.
Pancreatic Fat Content Detected by Computed Tomography and Its Significant Relationship With
Intraductal Papillary Mucinous Neoplasm.
Pancreas 2018;47:1087-1092.
11. Kasuga A, Hamamoto Y, Takeuchi A, Okano N, Togasaki K, Aoki Y, Suzuki T, Kawasaki K, Hirata
K, Sukawa Y, Kanai T, Takaishi H.

Post-progression survival following second-line chemotherapy in patients with advanced
pancreatic cancer previously treated with gemcitabine: a meta-analysis.
Invest New Drugs 2018;36:939-948.
12. Kinoshita S, Uraoka T, Nishizawa T, Naganuma M, Iwao Y, Ochiai Y, Fujimoto A, Goto O,Shimoda M, Ogata H, Kanai T, Yahagi N.
The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis.
Gastrointest Endosc 2018;87:1079-1084.
13. Kurokawa S, Kishimoto T, Mizuno S, Masaoka T, Naganuma M, Liang KC, Kitazawa M,Nakashima M, Shindo C, Suda W, Hattori M, Kanai T, Mimura M.
The effect of fecal microbiota transplantation on psychiatric symptoms among patients withirritable bowel syndrome, functional diarrhea and functional constipation: An open-label
observational study.
J Affect Disord 2018;235:506-512.
14. Masaoka T, Kameyama H, Yamane T, Yamamoto Y, Takeuchi H, Suzuki H, Kitagawa Y, Kanai T.
Pathophysiology of Potassium-competitive Acid Blocker-refractory Gastroesophageal Reflux and
the Potential of Potassium-competitive Acid Blocker Test.
J Neurogastroenterol Motil 2018;24:577-583.
15. Matsuoka K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H, Arai M, Sugimoto S, Iwao
Y, Ogata H, Hisamatsu T, Naganuma M, Kanai T, Mochizuki M, Hashiguchi M.
Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanesepatients with Crohn's disease.
PLoS One 2018;13:e0204632.
16. Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi
K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T,Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano
K, Shimosegawa T.
Evidence-based clinical practice guidelines for inflammatory bowel disease.
J Gastroenterol 2018;53:305-353.
17. Matsuoka K, Uemura Y, Kanai T, Kunisaki R, Suzuki Y, Yokoyama K, Yoshimura N, Hibi T.
Efficacy of Bifidobacterium breve Fermented Milk in Maintaining Remission of Ulcerative Colitis.
Dig Dis Sci 2018;63:1910-1919.
18. Matsuzaki J, Suzuki H, Togawa K, Yamane T, Mori H, Komori T, Masaoka T, Kanai T.
Burden of impaired sleep quality on work productivity in functional dyspepsia.
United European Gastroenterol J 2018;6:398-406.
19. Mikami Y, Takada Y, Hagihara Y, Kanai T.
Innate lymphoid cells in organ fibrosis.
Cytokine Growth Factor Rev 2018;42:27-36.
20. Minami K, Iwasaki E, Itoi T, Fukuhara S, Horibe M, Seino T, Kawasaki S, Katayama T, Takimoto
Y, Tamagawa H, Machida Y, Hamamoto Y, Ogata H, Kanai T.
Successful EUS-guided antegrade stenting for malignant severe biliary obstruction combined witha newly developed plastic stent.
Endosc Int Open 2018;6:E1336-e1339.
21. Miyanaga R, Hosoe N, Naganuma M, Hirata K, Fukuhara S, Nakazato Y, Ojiro K, Iwasaki E,Yahagi N, Ogata H, Kanai T.
Complications and outcomes of routine endoscopy in the very elderly.
Endosc Int Open 2018;6:E224-e229.
22. Miyoshi J, Matsuoka K, Yoshida A, Naganuma M, Hisamatsu T, Yajima T, Inoue N, Okamoto S,

Iwao Y, Ogata H, Ueno F, Hibi T, Kanai T.
5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis.
Intest Res 2018;16:635-640.
23. Miyoshi S, Tsugawa H, Matsuzaki J, Hirata K, Mori H, Saya H, Kanai T, Suzuki H.
Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9Expression.
Anticancer Res 2018;38:6163-6170.
24. Mizuno S, Nanki K, Kanai T.
[Future perspectives on fecal microbiota transplantation].
Nihon Shokakibyo Gakkai Zasshi 2018;115:449-459.
25. Mori H, Suzuki H, Matsuzaki J, Masaoka T, Kanai T.
Acquisition of double mutation in gyrA caused high resistance to sitafloxacin in Helicobacter
pylori after unsuccessful eradication with sitafloxacin-containing regimens.
United European Gastroenterol J 2018;6:391-397.
26. Mori K, Naganuma M, Mizuno S, Suzuki H, Kitazume MT, Shimamura K, Chiba S, Sugita A,Matsuoka K, Hisamatsu T, Kanai T.
beta-(1,3)-Glucan derived from Candida albicans induces inflammatory cytokines frommacrophages and lamina propria mononuclear cells derived from patients with Crohn's disease.
Intest Res 2018;16:384-392.
27. Murakami Y, Sugiyama K, Ebinuma H, Nakamoto N, Ojiro K, Chu PS, Taniki N, Saito Y, TerataniT, Koda Y, Suzuki T, Saito K, Fukasawa M, Ikeda M, Kato N, Kanai T, Saito H.
Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells.
BMC Cancer 2018;18:680.
28. Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A,Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T,Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T,Suzuki Y, Kanai T.
Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With
Ulcerative Colitis.
Gastroenterology 2018;154:935-947.
29. Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H,Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku
T.
Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethalendotoxic shock and post-influenza bacterial pneumonia.
PLoS Pathog 2018;14:e1006955.
30. Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima M,Takeshita K, Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T.
Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient withulcerative colitis.
Intest Res 2018;16:142-146.
31. Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori
S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo
H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T.
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric
Carcinogenesis.
Cell 2018;174:856-869.e17.
32. Nishizawa T, Akimoto T, Uraoka T, Mitsunaga Y, Maehata T, Ochiai Y, Fujimoto A, Goto O, Kanai

T, Yahagi N.
Endoscopic string clip suturing method: a prospective pilot study (with video).
Gastrointest Endosc 2018;87:1074-1078.
33. Nishizawa T, Suzuki H, Arita M, Kataoka Y, Fukagawa K, Ohki D, Hata K, Uraoka T, Kanai T,Yahagi N, Toyoshima O.
Pethidine dose and female sex as risk factors for nausea after esophagogastroduodenoscopy.
J Clin Biochem Nutr 2018;63:230-232.
34. Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M,Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa
Y, Kanai T, Sato T.
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during
Disease Progression.
Cell Stem Cell 2018;22:454-467.e6.
35. Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato
Y, Nakamura T, Kanai T, Sato T.
Reconstruction of the Human Colon Epithelium In Vivo.
Cell Stem Cell 2018;22:171-176.e5.
36. Sukawa Y, Hamamoto Y, Kanai T.
[Immune Checkpoint Induced Colitis].
Gan To Kagaku Ryoho 2018;45:1027-1030.
37. Sun X, Hosoe N, Miyanaga R, Kimura K, Mizuno S, Takabayashi K, Naganuma M, Niizeki H,Seki A, Ogata H, Kanai T.
A male Korean who was diagnosed with chronic enteropathy associated with SLCO2A1 (CEAS):
case report with literature review.
BMJ Open Gastroenterol 2018;5:e000223.
38. Taniki N, Nakamoto N, Chu PS, Mikami Y, Amiya T, Teratani T, Suzuki T, Tsukimi T, Fukuda S,
Yamaguchi A, Shiba S, Miyake R, Katayama T, Ebinuma H, Kanai T.
Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.
JCI Insight 2018;3.
39. Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S,Minamino T, Oike Y, Hokari R, Kanai T.
Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis.
J Clin Invest 2018;128:1581-1596.
40. Togasaki K, Sukawa Y, Kanai T, Takaishi H.
Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced orrecurrent gastric cancer: an evidence-based review of therapies.
Onco Targets Ther 2018;11:8239-8250.
41. Ugamura A, Chu PS, Nakamoto N, Taniki N, Ojiro K, Hibi T, Shinoda M, Obara H, Masugi Y,Yamaguchi A, Shiba S, Morikawa R, Usui S, Ebinuma H, Kitagawa Y, Saito H, Kanai T.
Liver Fibrosis Markers Improve Prediction of Outcome in Non-Acetaminophen-Associated AcuteLiver Failure.
Hepatol Commun 2018;2:1331-1343.
42. Wada M, Kato M, Hirai Y, Kubosawa Y, Sunata Y, Abe K, Hirata T, Takada Y, Banno S, Takatori
Y, Kinoshita S, Mori H, Takabayashi K, Kikuchi M, Kikuchi M, Suzuki M, Kanai T, Uraoka T.
Initial Management of Colonic Diverticular Bleeding: Observational Study.
Digestion 2018;98:41-47.
43. Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S,

Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe
M, Hibi T.
Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing inPatients With Crohn's Disease.
Clin Gastroenterol Hepatol 2018;16:542-549.e1.