The World Anti-Doping CodeTHE 2005
PROHIBITED LISTINTERNATIONAL
STANDARD

The official text of the Prohibited List shall be maintained by WADA and shall be
published in English and French. In the event of any conflict between the English
and French versions, the English version shall prevail.

This List shall come into effect on 1 January 2005.

THE 2005 PROHIBITED LISTWORLD ANTI-DOPING CODE
Valid 1 January 2005

The use of any drug should be limited to medically justified
indications
SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES(IN- AND OUT-OF-COMPETITION)
PROHIBITED SUBSTANCESS1. ANABOLIC AGENTS
Anabolic agents are prohibited.
1.

Anabolic Androgenic Steroids (AAS)

a. Exogenous* AAS, including:
18α-homo-17β-hydroxyestr-4-en-3-one; bolasterone; boldenone;boldione; calusterone; clostebol; danazol; dehydrochloromethyltestosterone; delta1-androstene-3,17-dione; delta1-androstenediol;delta1-dihydro-testosterone; drostanolone; ethylestrenol;
fluoxymesterone; formebolone; furazabol; gestrinone;
4-hydroxytestosterone; 4-hydroxy-19-nortestosterone; mestanolone;
mesterolone; metenolone; methandienone; methandriol;
methyldienolone; methyltrienolone; methyltestosterone; mibolerone;
nandrolone; 19-norandrostenediol; 19-norandrostenedione;
norbolethone; norclostebol; norethandrolone; oxabolone; oxandrolone;
oxymesterone; oxymetholone; quinbolone; stanozolol; stenbolone;tetrahydrogestrinone; trenbolone and other substances with a similar
chemical structure or similar biological effect(s).
b. Endogenous** AAS:
androstenediol (androst-5-ene-3β,17β-diol); androstenedione (androst-4ene-3,17-dione); dehydroepiandrosterone (DHEA); dihydrotestosterone;
testosterone.

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1and the following metabolites and isomers:
5α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane3β,17α-diol;, 5α-androstane-3β,17β-diol; androst-4-ene-3α,17α-diol;
androst-4-ene-3α,17β-diol; androst-4-ene-3β,17α-diol; androst-5-ene3α,17α-diol; androst-5-ene-3α,17β-diol; androst-5-ene-3β,17α-diol;
4-androstenediol (androst-4-ene-3β,17β-diol); 5-androstenedione(androst-5-ene-3,17-dione); epi-dihydrotestosterone; 3α-hydroxy-5αandrostan-17-one; 3β-hydroxy-5α-androstan-17-one;
19-norandrosterone; 19-noretiocholanolone.
Where a Prohibited Substance (as listed above) is capable of being produced by
the body naturally, a Sample will be deemed to contain such Prohibited Substance
where the concentration of the Prohibited Substance or its metabolites or markers
and/or any other relevant ratio(s) in the Athlete’s Sample so deviates from therange of values normally found in humans that it is unlikely to be consistent withnormal endogenous production. A Sample shall not be deemed to contain aProhibited Substance in any such case where the Athlete proves by evidence thatthe concentration of the Prohibited Substance or its metabolites or markers
and/or the relevant ratio(s) in the Athlete’s Sample is attributable to aphysiological or pathological condition. In all cases, and at any concentration, thelaboratory will report an Adverse Analytical Finding if, based on any reliable
analytical method, it can show that the Prohibited Substance is of exogenousorigin.
If the laboratory result is not conclusive and no concentration as referred to in theabove paragraph is found, the relevant Anti-Doping Organization shall conduct afurther investigation if there are serious indications, such as a comparison toreference steroid profiles, for a possible Use of a Prohibited Substance.
If the laboratory has reported the presence of a T/E ratio greater than four (4) toone (1) in the urine, further investigation is obligatory in order to determine
whether the ratio is due to a physiological or pathological condition, except if thelaboratory reports an Adverse Analytical Finding based on any reliable analyticalmethod, showing that the Prohibited Substance is of exogenous origin.
In case of an investigation, it will include a review of any previous and/orsubsequent tests. If previous tests are not available, the Athlete shall be tested
unannounced at least three times within a three month period.
Should an Athlete fail to cooperate in the investigations, the Athlete’s Sample
shall be deemed to contain a Prohibited Substance.

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22.

Other Anabolic Agents, including but not limited to:

Clenbuterol, zeranol, zilpaterol.
For purposes of this section:“exogenous” refers to a substance which is not capable of being produced by thebody naturally.
**“endogenous” refers to a substance which is capable of being produced by thebody naturally.
*

S2. HORMONES AND RELATED SUBSTANCES
The following substances, including other substances with a similar chemical
structure or similar biological effect(s), and their releasing factors, are prohibited:
1. Erythropoietin (EPO);
2. Growth Hormone (hGH), Insulin-like Growth Factor (IGF-1),
Mechano Growth Factors (MGFs);
3. Gonadotrophins (LH, hCG);
4. Insulin;
5. Corticotrophins.
Unless the Athlete can demonstrate that the concentration was due to aphysiological or pathological condition, a Sample will be deemed to contain a
Prohibited Substance (as listed above) where the concentration of the Prohibited
Substance or its metabolites and/or relevant ratios or markers in the Athlete’s
Sample so exceeds the range of values normally found in humans so that it isunlikely to be consistent with normal endogenous production.
The presence of other substances with a similar chemical structure or similar
biological effect(s), diagnostic marker(s) or releasing factors of a hormone listed
above or of any other finding which indicate(s) that the substance detected is ofexogenous origin, will be reported as an Adverse Analytical Finding.

S3. BETA-2 AGONISTSAll beta-2 agonists including their D- and L-isomers are prohibited. Their use
requires a Therapeutic Use Exemption.
As an exception, formoterol, salbutamol, salmeterol and terbutaline, whenadministered by inhalation to prevent and/or treat asthma and exercise-induced
asthma/broncho-constriction require an abbreviated Therapeutic Use Exemption.

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23 September 20043Despite the granting of a Therapeutic Use Exemption, when the Laboratory hasreported a concentration of salbutamol (free plus glucuronide) greater than
1000 ng/mL, this will be considered as an Adverse Analytical Finding unless theathlete proves that the abnormal result was the consequence of the therapeutic
use of inhaled salbutamol.

S4. AGENTS WITH ANTI-ESTROGENIC ACTIVITY
The following classes of anti-estrogenic substances are prohibited:
1. Aromatase inhibitors including, but not limited to, anastrozole,letrozole, aminogluthetimide, exemestane, formestane, testolactone.
2. Selective Estrogen Receptor Modulators (SERMs) including, but notlimited to, raloxifene, tamoxifen, toremifene.
3. Other anti-estrogenic substances including, but not limited to,clomiphene, cyclofenil, fulvestrant.

S5. DIURETICS AND OTHER MASKING AGENTS
Diuretics and other masking agents are prohibited.
Masking agents include but are not limited to:Diuretics*, epitestosterone, probenecid, alpha-reductase inhibitors (e.g.
finasteride, dutasteride), plasma expanders (e.g. albumin, dextran,hydroxyethyl starch).
Diuretics include:
acetazolamide, amiloride, bumetanide, canrenone, chlortalidone,etacrynic acid, furosemide, indapamide, metolazone, spironolactone,thiazides (e.g. bendroflumethiazide, chlorothiazide, hydrochlorothiazide),triamterene, and other substances with a similar chemical structure or similar
biological effect(s).
*A Therapeutic Use Exemption is not valid if an Athlete’s urine contains a diuretic
in association with threshold or sub-threshold levels of a Prohibited
Substance(s).

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PROHIBITED METHODS
M1. ENHANCEMENT OF OXYGEN TRANSFER
The following are prohibited:a.

Blood doping, including the use of autologous, homologous or heterologous
blood or red blood cell products of any origin, other than for medicaltreatment.

b.

Artificially enhancing the uptake, transport or delivery of oxygen, including
but not limited to perfluorochemicals, efaproxiral (RSR13) and modified
haemoglobin
products(e.g.
haemoglobin-based
blood
substitutes,microencapsulated haemoglobin products).

M2. CHEMICAL AND PHYSICAL MANIPULATION
The following is prohibited:
Tampering, or attempting to tamper, in order to alter the integrity and validity ofSamples collected in Doping Controls.
These include but are not limited to intravenous infusions*, catheterisation, andurine substitution.
*

Except as a legitimate acute medical treatment, intravenous infusions areprohibited.

M3. GENE DOPING
The non-therapeutic use of cells, genes, genetic elements, or of the modulation ofgene expression, having the capacity to enhance athletic performance, isprohibited.

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5SUBSTANCES AND METHODSPROHIBITED IN-COMPETITION
In addition to the categories S1 to S5 and M1 to M3 defined above,
the following categories are prohibited in competition:

PROHIBITED SUBSTANCES
S6. STIMULANTS
The following stimulants are prohibited, including both their optical (D- and L-)
isomers where relevant:Adrafinil, amfepramone, amiphenazole, amphetamine, amphetaminil,
benzphetamine, bromantan, carphedon, cathine*, clobenzorex, cocaine,
dimethylamphetamine, ephedrine**, etilamphetamine, etilefrine,
famprofazone, fencamfamin, fencamine, fenetylline, fenfluramine,
fenproporex, furfenorex, mefenorex, mephentermine, mesocarb,
methamphetamine, methylamphetamine, methylenedioxyamphetamine,methylenedioxymethamphetamine, methylephedrine**, methylphenidate,modafinil, nikethamide, norfenfluramine, parahydroxyamphetamine,
pemoline, phendimetrazine, phenmetrazine, phentermine, prolintane,
selegiline, strychnine, and other substances with a similar chemical structure orsimilar biological effect(s)***.
* Cathine is prohibited when its concentration in urine is greater than 5
micrograms per milliliter.
** Each of ephedrine and methylephedrine is prohibited when its
concentration in urine is greater than 10 micrograms per milliliter.
*** The substances included in the 2005 Monitoring Program (bupropion,caffeine, phenylephrine, phenylpropanolamine, pipradrol, pseudoephedrine,synephrine) are not considered as Prohibited Substances.
NOTE: Adrenaline associated with local anaesthetic agentsadministration (e.g. nasal, ophthalmologic) is not prohibited.

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orbylocal

6S7. NARCOTICS
The following narcotics are prohibited:buprenorphine, dextromoramide, diamorphine (heroin), fentanyl and its
derivatives, hydromorphone, methadone, morphine, oxycodone,oxymorphone, pentazocine, pethidine.

S8. CANNABINOIDS
Cannabinoids (e.g. hashish, marijuana) are prohibited.

S9. GLUCOCORTICOSTEROIDS
All glucocorticosteroids are prohibited when administered orally, rectally,intravenously or intramuscularly. Their use requires a Therapeutic Use Exemption
approval.
All other routes of administration require an abbreviated Therapeutic Use
Exemption.
Dermatological preparations are not prohibited.

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SUBSTANCES PROHIBITED IN PARTICULARSPORTS
P1. ALCOHOL
Alcohol (ethanol) is prohibited in-Competition only, in the following sports.
Detection will be conducted by analysis of breath and/or blood. The doping
violation threshold for each Federation is reported in parenthesis.
••
•
•
•

Aeronautic (FAI)
Archery (FITA)
Automobile (FIA)Billiards (WCBS)
Boules (CMSB)(0.20 g/L)
(0.10 g/L)
(0.10 g/L)
(0.20 g/L)
(0.10 g/L)••••

Karate (WKF)(0.10 g/L)
Modern Pentathlon (UIPM) (0.10 g/L)
for disciplines involving shooting
Motorcycling (FIM)(0.00 g/L)
Skiing (FIS)(0.10 g/L)

P2. BETA-BLOCKERS
Unless otherwise specified, beta-blockers are prohibited in-Competition only, inthe following sports.
•••••••••••

Aeronautic (FAI)
Archery (FITA) (also prohibitedout-of-competition)
Automobile (FIA)Billiards (WCBS)
Bobsleigh (FIBT)Boules (CMSB)
Bridge (FMB)
Chess (FIDE)
Curling (WCF)
Gymnastics (FIG)
Motorcycling (FIM)

••
•
•
•
•
•

Modern Pentathlon (UIPM) for
disciplines involving shooting
Nine-pin bowling (FIQ)
Sailing (ISAF) for match racehelms only
Shooting (ISSF) (also prohibitedout-of-competition)
Skiing (FIS) in ski jumping & freestyle snow board
Swimming (FINA) in diving &synchronised swimmingWrestling (FILA)

Beta-blockers include, but are not limited to, the following:
acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol,carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol,metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol.

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SPECIFIED SUBSTANCES*“Specified Substances”* are listed below:
Ephedrine, L-methylamphetamine, methylephedrine;
Cannabinoids;
All inhaled Beta-2 Agonists, except clenbuterol;
Probenecid;
All Glucocorticosteroids;
All Beta Blockers;
Alcohol.

* “The Prohibited List may identify specified substances which are particularly
susceptible to unintentional anti-doping rule violations because of their generalavailability in medicinal products or which are less likely to be successfully abused
as doping agents.” A doping violation involving such substances may result in a
reduced sanction provided that the “…Athlete can establish that the Use of such aspecified substance was not intended to enhance sport performance…”

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