CURRICULUM VITAE
April 2018
	 YOSHIHIRO YOSHIHARA, PH.D.
Team Leader
Laboratory for Systems Molecular Ethology
RIKEN Center for Brain Science
Office Address:
Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: yoshihiro.yoshihara@riken.jp

Tel. +81-48-467-1699

Fax +81-48-467-2306

Education/Training:
1980–1984

Faculty of Pharmaceutical Sciences, Kyoto University

1984–1989

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
Ph.D., May 1989 Thesis Supervisor: Masamichi SatohPositions and Employment:
1989-1991

Postdoctoral Fellow, Department of Neuroscience, Osaka Bioscience Institute, Osaka, Japan

1992

Assistant Professor, Department of Biochemistry, Osaka Medical College, Osaka, Japan

1992-1996

Lecturer, Department of Biochemistry, Osaka Medical College, Osaka, Japan

1996-1998

Associate Professor, Department of Biochemistry, Osaka Medical College, Osaka, Japan

1998-2009

Team Leader, Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Japan

2018-

Team Leader, Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Wako, Japan

Other Experience and Professional Memberships:
Editorial Boards:

Chemical Senses (2005-)
Frontiers in Synaptic Neuroscience (2008-)
Neural Systems and Circuits (2010-2012)
Journal of Biochemistry (2016-)

Professional Societies:

Society for Neuroscience, USA
The Japan Neuroscience Society
The Molecular Biology Society of JapanThe Japanese Biochemical Society
The Japanese Association for the Study of Taste and Smell (organizing committee)

Honors:2006

Young Investigator Award, The Japanese Association for the Study of Taste and Smell

2018

22nd Ando Momofuku Award of Excellence, ANDO Foundation

Publications:Peer-Reviewed Articles:
1 Tsunoda M, Miyamichi K, Eguchi R, Sakuma Y, Yoshihara Y, Kikusui T, Kuwahara M, Touhara K. Identification of
an intra- and inter-specific tear protein signal in rodents. Current Biology (in press)
2 Koide T, Yabuki Y, Yoshihara Y. Terminal nerve GnRH3 neurons mediate slow avoidance from carbon dioxide inlarval zebrafish. Cell Reports 22: 1115-1123 (2018)
3 Iwata T, Niimura Y, Kobayashi C, Shirakawa D, Suzuki H, Enomoto T, Touhara K, Yoshihara Y, Hirota J. A longrange cis-regulatory element for class I odorant receptor genes. Nature Communications 8: 885 (2017)
4 Ishii K, Osakada T, Mori H, Miyasaka N, Yoshihara Y, Miyamichi K, Touhara K. A labeled-line neural circuit forpheromone-mediated sexual behaviors in mice. Neuron 95: 123-137 (2017)
5 Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki-Kajiyama T, Yoshihara Y. An adenosine receptor for olfaction
in fish. Current Biology 27:1437-1447 (2017)
6 Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y,
Yoshihara Y. Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior. Nature
Neuroscience 19: 897-904 (2016)
7 Eckstrum KS, Weis KE, Baur NG, Yoshihara Y, Raetzman LT. Icam5 expression exhibits sex differences in the
neonatal pituitary and is regulated by estradiol and bisphenol A. Endocrinology 157: 1408-1420 (2016)
8 Osterhout JA, Stafford BK, Nguyen PL, Yoshihara Y, Huberman AD. Contactin-4 mediates axon-target specificity
and functional development of the accessory optic system. Neuron 86: 985-999 (2015)
9 Deleyrolle L, Sabourin JC, Rothhut B, Fujita H, Guichet PO, Teigell M, Ripoll C, Chauvet N, Perrin F, Mamaeva D,
Noda T, Mori K, Yoshihara Y, Hugnot JP. OCAM regulates embryonic spinal cord stem cell proliferation bymodulating ErbB2 receptor. PLoS One 10: e0122337 (2015)
10 Gu Z, Imai F, Kim IJ, Fujita H, Katayama K, Mori K, Yoshihara Y, Yoshida Y. Expression of the immunoglobulin
superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One 10:
e0121550 (2015)
11 Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K,
Shimizu T, Hibi M. Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar
neural circuitry. Developmental Biology 397: 1-17 (2015)
12 Amo R, Fredes F, Kinoshita M, Aoki R, Aizawa H, Agetsuma M, Aoki T, Shiraki T, Kakinuma H, Matsuda M,
Yamazaki M, Takahoko M, Tsuboi T, Higashijima S, Miyasaka N, Koide T, Yabuki Y, Yoshihara Y, Fukai T,
Okamoto H. The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for
adaptive active avoidance of danger. Neuron 84: 1034-1048 (2014)13 Miyasaka N, Arganda-Carreras I, Wakisaka N, Masuda M, Sümbül U, Seung HS, Yoshihara Y. Olfactory
projectome in the zebrafish forebrain revealed by genetic single-neuron labeling. Nature Communications 5:3639 (2014)
14 Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R,
Harada A. Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis.
Journal of Cell Science 127: 422-431 (2014)
15 Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR,
Yoshihara Y. Goofy coordinates the acuity of olfactory signaling. Journal of Neuroscience 33: 12987-12996(2013)
16 Olivera A, Kitamura Y, Wright L, Allende ML, Chen W, Kaneko-Goto T, Yoshihara Y, Proia RL, Rivera J.
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.
Journal of Leukocyte Biology 94: 1013-1024 (2013)17 Braubach OR, Miyasaka N, Koide T, Yoshihara Y, Croll RP, Fine A. Experience-dependent vs. experienceindependent postembryonic development of distinct groups of zebrafish olfactory glomeruli. Journal of
Neuroscience 33: 6905-6916 (2013)

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18 Tachikawa KS, Yoshihara Y, Kuroda KO. Behavioral transition from attack to parenting in male mice: a crucialrole of the vomeronasal system. Journal of Neuroscience 33: 5120-5126 (2013)19 Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y. Vitronectin induces phosphorylation of
ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. Journalof Biological Chemistry 287: 39041-39049 (2012)20 Mizuguchi R, Naritsuka H, Mori K, Mao CA, Klein WH, Yoshihara Y. Tbr2 deficiency in mitral and tufted cells
disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. Journal of Neuroscience
32: 8831-8844 (2012)
21 Walling SG, Brown RAM, Miyasaka N, Yoshihara Y, Harley CW. Selective WGA uptake in the hippocampus fromthe locus coeruleus of DBH-WGA transgenic mice. Frontiers in Behavioral Neuroscience 6: 23 (2012)22 Mori Y, Matsui T, Furutani Y, Yoshihara Y, Fukuda M. Small GTPase Rab17 regulates the dendritic
morphogenesis and postsynaptic development of hippocampal neurons. Journal of Biological Chemistry 287:8963-8973 (2012)
23 Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern P, Tsuboi A.
5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborninterneurons in the mouse olfactory bulb. Journal of Neuroscience 32: 2217-2226 (2012)24 Langhauser M, Ustinova J, Rivera-Milla E, Ivannikov D, Seidl C, Slomka C, Finne J, Yoshihara Y, Bastmeyer M,
Bentrop J. Ncam1a and Ncam1b – two carriers of polysialic acid with different functions in the developing
zebrafish nervous system. Glycobiology 22: 196-209 (2012)
25 Matsumoto I, Ohmoto M, Narukawa M, Yoshihara Y, Abe K. Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Nature Neuroscience 14: 685-687 (2011)26 Mitsui S, Igarashi KM, Mori K, Yoshihara Y. Genetic visualization of the secondary olfactory pathway in Tbx21
transgenic mice. Neural Systems and Circuits 1: 5 (2011)27 Ohmoto M, Maeda N, Abe K, Yoshihara Y, Matsumoto I. Genetic tracing of bitter taste pathway in t2r5-WGA
transgenic mice. Biochemical and Biophysical Research Communications 400: 734-738 (2010)28 Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K. A
male mouse pheromone ESP1 enhances female sexual behaviour via a select vomeronasal receptor. Nature
466: 118-122 (2010)
29 Takeuchi H, Inokuchi K, Aoki M, Suto F, Tsuboi A, Matsuda I, Suzuki M, Aiba A, Serizawa S, Yoshihara Y,
Fujisawa H, Sakano H. Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map
topography at the bulb. Cell 141: 1056-1067 (2010)
30 Koide T, Miyasaka N, Morimoto K, Asakawa K, Urasaki A, Kawakami K, Yoshihara Y. Olfactory neural circuitry for
attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish. Proceedings of
National Academy of Sciences USA 106: 9884-9889 (2009)31 Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H, Yoshihara Y. From the olfactory bulb tohigher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. Journal of
Neuroscience 29: 4756-4767 (2009)32 Ohmoto M, Matsumoto I, Yasuoka A, Yoshihara Y, Abe K. Genetic tracing of the gustatory and trigeminal neuralpathways originating from T1R3-expressing chemosensory cells. Molecular and Cellular Neuroscience 38:505-517 (2008)33 Kaneko-Goto T, Yoshihara S, Miyazaki H, Yoshihara Y. BIG-2 mediates olfactory axon convergence to target
glomeruli. Neuron 57: 834-846 (2008)
34 Ichinohe N, Knight A, Ogawa M, Ohshima T, Mikoshiba K, Yoshihara Y, Terashima T, Rockland KS. Unusual
patch-matrix organization in the retrosplenial cortex of the reeler mouse and Shaking Rat Kawasaki. Cerebral
Cortex 18: 1125-1138 (2008)
35 Furutani Y, Matsuno H, Kawasaki M, Sasaki T, Mori K, Yoshihara Y. Interaction between telencephalin and ERM
family proteins mediates dendritic filopodia formation. Journal of Neuroscience 27: 8866-8876 (2007)

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36 Sato Y, Miyasaka N, Yoshihara Y. Hierarchical regulation of odorant receptor gene choice and subsequent axonal
projection of olfactory sensory neurons in zebrafish. Journal of Neuroscience 27: 1606-1615 (2007)37 Miyasaka N, Knaut H, Yoshihara Y. Cxcl12/Cxcr4 chemokine signaling is required for placode assembly andsensory axon pathfinding in the zebrafish olfactory system. Development 134: 2459-2468 (2007)38 Mitsui S, Saito M, Mori K, Yoshihara Y. A transcriptional enhancer that directs transgene expression in thetelencephalic neurons. Cerebral Cortex 17: 522-530 (2007)
39 Oka Y, Katada S, Omura M, Suwa M, Yoshihara Y, Touhara K. Odorant receptor map in the mouse olfactory bulb:
in vivo sensitivity and specificity of receptor-defined glomeruli. Neuron 52: 857-869 (2006)
40 Hirata T, Nakazawa M, Yoshihara S, Kitamura K, Yoshihara Y, Hibi M. Zinc finger gene Fez is required fordevelopment of olfactory system in mouse. Development 133: 1433-1443 (2006)
41 Matsuno H, Okabe S, Mishina M, Yanagida T, Mori K, Yoshihara Y. Telencephalin slows spine maturation.
Journal of Neuroscience 26: 1776-1786 (2006)
42 Sato Y, Miyasaka N, Yoshihara Y. Mutually exclusive glomerular innervation by two distinct types of olfactory
sensory neurons revealed in transgenic zebrafish. Journal of Neuroscience 25: 4889-4897 (2005)
43 Miyasaka N, Sato Y, Yeo SY, Hutson LD, Chien CB, Okamoto H, Yoshihara Y. Robo2 is required for establishmentof a precise glomerular map in the zebrafish olfactory system. Development 132: 1283-1293 (2005)
44 Mitsui S, Saito M, Hayashi K, Mori K, Yoshihara Y. A novel phenylalanine-based targeting signal directs
telencephalin to neuronal dendrites. Journal of Neuroscience 25: 1122-1131 (2005)
45 Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y. Arx homeobox gene is essential for developmentof mouse olfactory system. Development 132: 751-762 (2005)
46 Inaki K, Nishimura S, Nakashiba T, Itohara S, Yoshihara Y. Laminar organization of the developing lateralolfactory tract revealed by differential expression of cell recognition molecules. Journal of Comparative
Neurology 479: 243-256 (2004)
47 Nagayama S, Takahashi YK, Yoshihara Y, Mori K. Mitral and tufted cells differ in the decoding manner of odor
maps in the rat olfactory bulb. Journal of Neurophysiology 91: 2532-2540 (2004)
48 Hasegawa S, Yamaguchi M, Nagao H, Yoshihara Y, Mori K. Activated natural killer cells adhere to cultured
hippocampal neurons and affect the dendritic morphology. Journal of Neuroimmunology 151: 126-136(2004)
49 Inoue M, Nishimura S, Hori G, Nakahara H, Saito M, Yoshihara Y, Amari S. Improved parameter estimation forvariance-stabilizing transformation of gene-expression microarray data. Journal of Bioinformatics andComputational Biology 2: 669-679 (2004)
50 Nishiyori A, Hanno Y, Saito M, Yoshihara Y. Aberrant transcription of unrearranged T cell receptor b gene inmouse brain. Journal of Comparative Neurology 469: 214-226 (2004)
51 Sapir T, Geiman RJ, Wang Z, Belasquez T, Mitsui S, Yoshihara Y, Frank E, Alvarez FJ, Goulding M. Pax6 and En1
regulate distinct aspects of Renshaw cell development. Journal of Neuroscience 24: 1255-1264 (2004)
52 Serizawa S, Miyamichi K, Nakatani H, Suzuki M, Saito M, Yoshihara Y, Sakano H. Negative feedback regulation
ensures the one receptor – one olfactory sensory neuron rule in mouse. Science 302: 2088-2094 (2003)
53 Hanno Y, Nakahira M, Jishage K, Noda T, Yoshihara Y. Tracking mouse visual pathways with WGA transgene.
European Journal of Neuroscience 18: 2910-2914 (2003)
54 Ichinohe N, Yoshihara Y, Hashikawa T, Rockland KS. Developmental study of dendritic bundles in layer 1 of the
rat granular retrosplenial cortex with special reference to a cell adhesion molecule, OCAM. European Journalof Neuroscience 18: 1764-1774 (2003)
55 Treloar HB, Gabeau D, Yoshihara Y, Mori K, Greer CA. Inverse expression of OCAM in a subset of olfactory axons
and a subset of mitral/tufted cells in the developing olfactory bulb. Journal of Comparative Neurology 458:
389-403 (2003)
56 Kinoshita N, Mizuno T, Yoshihara Y. Adenovirus-mediated WGA gene delivery for transsynaptic labeling of mouseolfactory pathways. Chemical Senses 27: 215-223 (2002)

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57 Mizuno T, Kawasaki M, Nakahira M, Kagamiyama H, Kikuchi Y, Okamoto H, Mori K, Yoshihara Y. Moleculardiversity in zebrafish NCAM family: three members with different VASE usage and distinct localization.
Molecular and Cellular Neuroscience 18: 119-130 (2001)
58 Nagao H, Yoshihara Y, Mitsui S, Fujisawa H, Mori K. Two mirror-image sensory maps with domain organization in
the mouse main olfactory bulb. NeuroReport 11: 3023-3027 (2000)
59 Tian L, Nyman H, Kilgannon P, Yoshihara Y, Mori K, Andersson LC, Rauvala H, Gallatin WM, Gahmberg CG.
Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. Journal of Cell Biology
150: 243-252 (2000)
60 Tian L, Kilgannon P, Yoshihara Y, Mori K, Gallatin WM, Carpen O, Gahmberg CG. Binding of T lymphocytes tohippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte
integrin CD11a/CD18. European Journal of Immunology 30: 810-818 (2000)
61 Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-Morimoto T, Yuasa Y, Yoshihara Y, Nose A,
Okano H. The GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
Journal of Neuroscience Research 59: 94-99 (2000)
62 Mizuno T, Yoshihara Y, Kagamiyama H, Ohsawa K, Imai Y, Kohsaka S, Mori K. Neuronal adhesion moleculetelencephalin induces rapid cell spreading of microglia. Brain Research 849: 58-66 (1999)
63 Yoshihara Y, Mizuno T, Nakahira M, Kawasaki M, Watanabe Y, Kagamiyama H, Jishage K, Ueda O, Suzuki H,
Tabuchi K, Sawamoto K, Okano H, Noda T, Mori K. A genetic approach to visualization of multisynaptic neuralpathways using plant lectin transgene. Neuron 22: 33-41 (1999)
64 Nakai Y, Yoshihara Y, Hayashi H, Kagamiyama H. cDNA cloning and characterization of mouse nifS-like protein,mNfs1: mitochnodrial localization of eukaryotic NifS-like proteins. FEBS Letters 433: 143-148 (1998)
65 Okuda-Ashitaka E, Minami T, Tachibana S, Yoshihara Y, Nishiuchi Y, Kimura T, Ito S. Nocistatin, a peptide
blocking nociceptin action in pain transmission. Nature 392: 286-289 (1998)
66 Sakurai E, Hashikawa T, Yoshihara Y, Kaneko S, Satoh M, Mori K. Involvement of dendritic adhesion moleculetelencephalin in long-term potentiation. NeuroReport 9: 881-886 (1998)
67 Benson DL, Yoshihara Y, Mori K. Polarization and cell-type specific localization of telencephalin, an ICAM-related
protein, in hippocampal neurons. Journal of Neuroscience Research 52: 43-53 (1998)
68 Tamada A, Yoshihara Y, Mori K. Telencephalin, a dendritic adhesion molecule, promotes neurite outgrowth.
Neuroscience Letters 240: 163-166 (1998)
69 von Campenhausen H, Yoshihara Y, Mori K. OCAM reveals segregated mitral/tufted cell pathways in developing
accessory olfactory bulb. NeuroReport 8: 2607-2612 (1997)
70 Sugino H, Yoshihara Y, Copeland NJ, Gilbert DL, Jenkins NA, Mori K. Genomic organization and chromosomal
localization of the mouse telencephalin gene, a neuronal member of the ICAM family. Genomics 43: 209-215(1997)
71 Yoshihara Y, Kawasaki M, Tamada A, Fujita H, Hayashi H, Kagamiyama H, Mori K. OCAM: a new member of theNCAM family related to zone-to-zone projection of olfactory and vomeronasal axons. Journal of Neuroscience
17: 5830-5842 (1997)
72 Hino H, Mori K, Yoshihara Y, Iseki E, Akiyama H, Nishimura T, Ikeda K, Kosaka K. Reduction of telencephalin
immunoreactivity in the brain of patients with Alzheimer's disease. Brain Research 753: 353-357 (1997)
73 Fujimori KE, Takauji R, Yoshihara Y, Tamada A, Mori K, Tamamaki N. A procedure for in situ hybridization
combined with retrograde labeling of neurons: application to the study of cell adhesion molecule expression in
DiI-labeled rat pyramidal neurons. Journal of Histochemistry and Cytochemistry 45: 455-459 (1997)
74 Tian L, Yoshihara Y, Mizuno T, Mori K, Gahmberg CG. The neuronal glycoprotein, telencephalin, is a cellular
ligand for CD11a/CD18 leukocyte integrin. Journal of Immunology 158: 928-936 (1997)75 Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K. cDNA cloning and chromosomal localization of thehuman telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. Journal of
Biological Chemistry 272: 1156-1163 (1997)

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76 Yoshihara Y, Kawasaki M, Tamada A, Nagata S, Kagamiyama H, Mori K. Overlapping and differential expressionof BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of theimmunoglobulin superfamily. Journal of Neurobiology 28: 51-69 (1995)
77 Yoshihara Y, Kawasaki M, Tani A, Nagata S, Kagamiyama H, Mori K. BIG-1: a new TAG-1/F3-related member ofthe immunoglobulin superfamily with neurite outgrowth-promoting activity. Neuron 13: 415-426 (1994)
78 Yoshihara Y, Oka S, Nemoto Y, Watanabe Y, Nagata S, Kagamiyama H, Mori K. An ICAM-related neuronalglycoprotein, telencephalin, with brain segment-specific expression. Neuron 12: 541-553 (1994)
79 Koshimoto H, Katoh K, Yoshihara Y, Nemoto Y, Mori K. Immunohistochemical demonstration of embryonicexpression of an odor receptor protein and its zonal distribution in the rat olfactory epithelium. Neuroscience
Letters 169: 73-76 (1994)
80 Katoh K, Yoshihara Y, Mori K. Development of glomerular structure in rabbit olfactory bulb: three-dimentional
reconstitution under the confocal laser scanning microscopy. NeuroImage 1: 199-207 (1994)
81 Nemoto Y, Ikeda J, Katoh K, Koshimoto H, Yoshihara Y, Mori K. R2D5 antigen: a calcium-binding phosphoprotein
predominantly expressed in olfactory receptor neurons. Journal of Cell Biology 123: 963-976 (1993)
82 Kawasaki M, Yoshihara Y, Yamaji M, Watanabe Y. Expression of prostaglandin endoperoxide synthase in rat brain.
Molecular Brain Research 19: 39-46 (1993)
83 Yoshihara Y, Katoh K, Mori K. Odor stimulation causes disappearance of R4B12 epitope on axonal surface
molecule of olfactory sensory neurons. Neuroscience 53:101-110 (1993)
84 Koshimoto H, Katoh K, Yoshihara Y, Mori K. Distribution of putative odour receptor proteins in olfactory
epithelium. NeuroReport 3: 521-523 (1992)
85 Yoshihara Y, Yamaji M, Kawasaki M, Watanabe Y. Ontogeny of cytosolic phospholipase A activity in rat brain.
Biochemical and Biophysical Research Communications 185: 350-3 (1992)
86 Tani A, Yoshihara Y, Mori K. Increase in cytoplasmic free Ca2+ elicited by noradrenalin and serotonin in cultured
local interneurons of mouse olfactory bulb. Neuroscience 49: 193-199 (1992)
87 Yoshihara Y, Oka S, Watanabe Y, Mori K. Spatially and developmentally regulated expression of HNK-1
carbohydrate antigen on a novel phosphatidylinositol-anchored glycoprotein in rat brain. Journal of Cell
Biology 115: 731-744 (1991)
88 Satoh M, Ueda H, Tamura S, Yoshihara Y, Fukushima N. Inositol 1,4,5-trisphosphate activates Ca2+ channels in
the plasma membranes of rat brain nerve terminals. Advances in Experimental Medicine and Biology 287:
97-100 (1991)
89 Yoshihara Y, Watanabe Y. Translocation of phospholipase A2 from cytosol to membrane in rat brain induced bycalcium ions. Biochemical and Biophysical Research Communications 170: 484-490 (1990)
90 Yoshihara Y, Ueda H, Fujii N, Shide A, Yajima H, Satoh M. Purification of a novel type of calcium-activated neutral
protease from rat brain – possible involvement in production of the neuropeptide, kyotorphin, from calpastatin
fragments -. Journal of Biological Chemistry 265: 5809-5815 (1990)91 Ueda H, Yoshihara Y, Misawa H, Fukushima N, Katada T, Ui M, Takagi H, Satoh M. The kyotorphin (tyrosinearginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C
assays. Journal of Biological Chemistry 264: 3732-3741 (1989)
92 Yoshihara Y, Ueda H, Imajoh S, Takagi H, Satoh M. Calcium-activated neutral protease (CANP), a putative
processing enzyme of the neuropeptide, kyotorphin, in the brain. Biochemical and Biophysical ResearchCommunications 155: 546-553 (1988)
93 Ueda H, Fukushima N, Yoshihara Y, H. Takagi. A Met-enkephalin releaser, kyotorphin-induced release of plasma
membrane-bound Ca2+ from rat brain synaptosomes. Brain Research 419: 197-200 (1987)
94 Kitabatake S, Tsurutani R, Nakajima H, Tomita K, Yoshihara Y, Ueda H, Takagi H, Imahori K. A novel method forthe synthesis of kyotorphin, Tyr-Arg, and 3H-Tyr-Arg, catalyzed by tyrosyl-tRNA synthetase from Bacillus

stearothermophilus. Pharmaceutical Research 4: 154-157 (1987)

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95 Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H. Kyotorphin (tyrosine-arginine) synthetasein rat brain synaptosomes. Journal of Biological Chemistry 262: 8165-8173 (1987)
96 Ueda H, Yoshihara Y, Takagi H. A putative Met-enkephalin releaser, kyotorphin enhances intracellular Ca2+ in thesynaptosomes. Biochemical and Biophysical Research Communications 137: 897-902 (1986)
97 Ueda H, Matsumoto S, Yoshihara Y, Fukushima N, Takagi H. Uptake and release of kyotorphin in the rat brain
synaptosomes. Life Sciences 38: 2405-2411 (1986)
98 Ueda H, Yoshihara Y, Nakamura A, Shiomi H, Satoh M, Takagi H. How is kyotorphin (Tyr-Arg) generated in thebrain? Neuropeptide 5: 525-528 (1985)
Review Articles:
1 Miyasaka N, Wanner AA, Li J, Mack-Bucher J, Genoud C, Yoshihara Y, Friedrich RW. Functional development of
the olfactory system in zebrafish. Mechanisms of Development 130: 336-346 (2013)
2 Yoshihara Y, De Roo M, Muller D. Dendritic spine formation and stabilization. Current Opinion in
Neurobiology 19: 146-153 (2009)
3 Miyasaka N, Sato Y, Yoshihara Y. Axon guidance of olfactory sensory neurons in zebrafish. Chemical Senses
30: 92-93 (2005)
4 Y. Yoshihara. Visualizing selective neural pathways with WGA transgene: combination of neuroanatomy withgene technology. Neuroscience Research 44: 133-140 (2002)
5 Yoshihara Y, Nagao H, Mori K. Sniffing out odors with multiple dendrites. Science 291: 835-837 (2001)
6 Mori K, von Campenhausen H, Yoshihara Y. Zonal organization in mammalian olfactory system. The Royal
Society Philosophical Transactions: Biological Sciences 355: 1801-1812 (2000)
7 Mori K, Nagao H, Yoshihara Y. The olfactory bulb: coding and processing of odor molecule information. Science
286: 711-715 (1999)
8 Yoshihara Y, Mori K. Basic principles and molecular mechanisms of olfactory axon pathfinding. Cell and Tissue
Research 290: 457-463 (1997)
9 Mori K, Yoshihara Y. Molecular recognition and olfactory processing in the mammalian olfactory system.
Progress in Neurobiology 45: 585-620 (1995)
10 Yoshihara Y, Mori K. Telencephalin: a neuronal area code molecule? Neuroscience Research 21: 119-124(1994)
11 Yoshihara Y, Oka S, Ikeda J, Mori K. Immunoglobulin superfamily molecules in the nervous system.
Neuroscience Research 10: 83-105 (1991)
Book Chapters:
1 Miyasaka N, Wakisaka N, Yoshihara Y. Genetic mosaic labeling and immunofluorescence techniques in zebrafish
brain. In Immunocytochemistry and Related Techniques, Neuromethods (eds. A. Merighi and L. Loss) pp.81-92,
Springer (2015)
2 Yoshihara Y. Zebrafish olfactory system. In Olfactory System: How is the Odor Information Translated into

Motivational Behaviors in the Brain? (ed. K. Mori) pp.71-96 Springer (2014)
3 Yoshihara Y. Molecular genetic dissection of the zebrafish olfactory system. In Chemosensory Systems in

Mammals, Fishes and Insects (eds. W. Meyerhof and S. Korsching) pp.97-120, Springer (2009)
4 Yoshihara Y. Immunoglobulin superfamily cell adhesion molecules. In Encyclopedic References of Neuroscience(eds. M. D. Binder, N. Hirokawa, U. Windhorst) pp.1923-1926 (2009)
5 Yoshihara Y, Mori K. IgSF molecules involved in olfactory axon projection. In Molecular Basis of Axon Growth andNerve Pattern Formation (ed. H. Fujisawa) pp.143-153, Karger (1997)
6 Mori K, Tamada A, Sugino H, Mizuno T, Yoshihara Y. Multiple functional roles of brain segment-specific neuronalrecognition molecule, telencephalin. In Integrative and Molecular Approach to Brain Function. (eds. M. Ito and Y.
Miyashita) pp.97-106, Elsevier (1996)

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Invited Talks:
03/1996 19th Taniguchi International Symposium on Brain Sciences, Kyoto, Japan
03/1997 20th Taniguchi International Symposium on Brain Sciences, Kyoto, Japan
12/1997 Senri Life Science Foundation “Shin-Tekijuku” Osaka, Japan
12/1997 20th Annual Meeting for the Molecular Biology Society of Japan, Kyoto, Japan
07/1998 Workshop of MEXT Grant “Neuronal Apoptosis”, Hamamatsu, Japan
09/1998 Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
09/1998 COE International Symposium on “Plasticity and Regeneration of Neural Network”, Tokyo, Japan
10/1998 71st Annual Meeting for Japanese Biochemistry Society, Nagoya, Japan
11/1998 20th Annual Meeting for Japan Society for Biomedical Gerontology, Tokyo, Japan
12/1998 Osaka University, Graduate School of Engineering Science, Osaka, Japan
12/1998 Tsukuba University, Tsukuba, Japan
07/1999 22nd Annual Meeting for Japan Neuroscience Society, Osaka, Japan
10/1999 1st MIT-RIKEN Neuroscience Symposium on “New Frontiers in Brain Science”, Boston, USA
10/1999 72nd Annual Meeting for Japanese Biochemistry Society, Yokohama, Japan
10/1999 Kyoto University, Institute for Virus Research, Kyoto, Japan
11/1999 6th Synapse Research Meeting, Okazaki, Japan
02/2000 Azabu University, Sagamihara, Japan
02/2000 8th International Conference on “Peace through Mind/Brain Science”, Hamamatsu, Japan
04/2000 22nd Annual Meeting for Japanese Society of Biological Psychiatry, Tokyo, Japan
04/2000 Japanese Biochemistry Society, Kanto Branch Symposium, Yokohama, Japan
04/2000 National Institute of Genetics, Mishima, Japan
09/2000 24th Annual Meeting for Japan Neuroscience Society, Kyoto, Japan
11/2000 2nd Korea-Japan Joint Workshop on Neurobiology and Neuroinformatics, Kyongju, Korea
03/2001 78th Annual Meeting for Physiological Society of Japan, Kyoto, Japan
04/2001 RIKEN BSI Neuronal Function Research Group 1st Workshop, Wako, Japan
06/2001 Tokyo Medical and Dental University, Tokyo, Japan
07/2001 Nagasaki University, Faculty of Pharmaceutical Sciences, Nagasaki, Japan
07/2001 26th Workshop of Japan Society of Histochemistry and Cytochemistry, Kyoto, Japan
10/2001 35th Annual Meeting of Japanese Association for the Study of Taste and Smell, Kochi, Japan
12/2001 National Institute for Basic Biology, Okazaki, Japan
12/2001 24th Annual Meeting for the Molecular Biology Society of Japan, Yokohama, Japan
03/2002 World Brain Awareness Week, Wako, Japan
05/2002 The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
05/2002 RIKEN BSI Neuronal Function Research Group 2nd Workshop, Wako, Japan
03/2004 RIKEN BSI-CDB Joint Symposium, Kobe, Japan
10/2004 Tohoku University, Institute of Development, Aging and Cancer, Sendai, Japan
12/2004 27th Annual Meeting for the Molecular Biology Society of Japan, Kobe, Japan
07/2005 University of Hohenheim, Institute of Physiology, Stuttgart, Germany
07/2005 28th Annual Meeting for Japan Neuroscience Society, Yokohama, Japan
08/2005 Summer Workshop of MEXT Grant “Tougou-Nou”, Nagano, Japan
10/2005 The University of Tokyo, Graduate School of Medicine, Tokyo, Japan
10/2005 Osaka University, Graduate School of Frontier Biosciences, Osaka, Japan
11/2005 3rd International Symposium on Taste and Olfactory Perception, Fukuoka, Japan
11/2005 Gunma University, Institute for Molecular and Cellular Regulation, Maebashi, Japan
06/2006 Kyoritsu College of Pharmacy, Tokyo, Japan

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07/2006 40th Annual Meeting of Japanese Association for the Study of Taste and Smell, Fukuoka, Japan
07/2006 29th Annual Meeting for Japan Neuroscience Society, Kyoto, Japan
11/2006 The University of Tokyo, Faculty of Pharmaceutical Sciences, Tokyo, Japan
11/2006 Hokkaido University, Faculty of Pharmaceutical Sciences, Sapporo, Japan
12/2006 Nagaoka Institute of Technology, Nagaoka, Japan
01/2007 Kyushu University, Faculty of Science, Fukuoka, Japan
03/2007 National Institute of Genetics, Mishima, Japan
06/2007 Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
07/2007 9th China-Japan-Korea Joint Workshop on Neurobiology and Neuroinformatics, Cheju, Korea
09/2007 30th Annual Meeting for Japan Neuroscience Society, Yokohama, Japan
11/2007 5th International Symposium on Taste and Olfactory Perception, Fukuoka, Japan
11/2007 6th MIT-RIKEN Neuroscience Symposium on “New Frontiers in Brain Science”, Boston, USA
11/2007 Yale University School of Medicine, New Haven, USA
12/2007 30th Annual Meeting for the Molecular Biology Society of Japan, Yokohama, Japan
07/2008 31st Annual Meeting for Japan Neuroscience Society, Tokyo, Japan
09/2008 18th European Chemoreception Research Organization Congress, Portoroz, Slovenia
11/2008 Kochi University School of Medicine, Kochi, Japan
12/2008 46th Annual Meeting for the Biophysical Society of Japan, Fukuoka, Japan
05/2009 Japan Cement Association, Tokyo, Japan
09/2009 UCSF Neuroscience Graduate Program, San Francisco, USA
09/2009 43rd Annual Meeting of Japanese Association for the Study of Taste and Smell, Asahikawa, Japan
12/2009 32nd Annual Meeting for the Molecular Biology Society of Japan, Yokohama, Japan
04/2010 Nara Medical University, Nara, Japan
05/2010 87th Annual Meeting for Physiological Society of Japan, Morioka, Japan
05/2010 Janelia Farm Conference: Form and Function of the Olfactory System, Ashburn, USA
07/2010 Tohoku University GCOE Retreat, Sendai, Japan
10/2010 10th China-Japan-Korea Joint Workshop on Neurobiology and Neuroinformatics, Kunming, China
11/2010 International Symposium on Systems Molecular Ethology, Tokyo, Japan
09/2011 34th Annual Meeting for Japan Neuroscience Society, Tokyo, Japan
09/2011 84th Annual Meeting for Japanese Biochemistry Society, Kyoto, Japan
11/2011 Senri Life Science Seminar: “Smell, Scent and Pheromone”, Osaka, Japan
12/2011 International Institute for Advanced Studies, Research Conference, Kyoto, Japan
01/2012 Nagoya University GCOE Symposium, Nagoya, Japan
06/2012 16th International Symposium on Olfaction and Taste (ISOT), Stockholm, Sweden
09/2012 Workshop on “Neural Bases for Olfactory Information Processing”, Tokyo, Japan
09/2012 35th Annual Meeting for Japan Neuroscience Society, Nagoya, Japan
11/2012 Cold Spring Harbor Asia Conference on “Neural Circuit Basis of Behavior”, Suzhou, China
01/2013 University of Hyogo, Graduate School of Life Science, Harima, Japan
02/2013 RIKEN Joint Retreat, Shizuoka, Japan
02/2013 International Symposium on “Sensory Systems and Neural Circuits”, Tokyo, Japan
02/2013 International Institute for Advanced Studies, Research Conference, Kyoto, Japan
03/2013 90th Annual Meeting for Physiological Society of Japan, Tokyo, Japan
06/2013 36th Annual Meeting for Japan Neuroscience Society, Kyoto, Japan
11/2013 11th International Symposium on Taste and Olfactory Perception, Fukuoka, Japan
11/2013 Autumn Symposium: Japan Society of Developmental Biologists, Kobe, Japan
12/2013 National Institute of Physiological Science, Meeting on “Memory Circuit”, Okazaki, Japan
01/2014 Tokyo Institute of Technology, Workshop on “Sensory Systems”, Yokohama, Japan

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05/2014 Takasago International Corporation, Kanagawa, Japan
05/2014 ERATO Touhara Chemosensory Signal Project Symposium, Tokyo, Japan
07/2014 Okinawa Institute of Science and Technology (OIST) Developmental Neurobiology Course, Okinawa, Japan
09/2014 24th European Chemoreception Research Organization Congress, Dijon, France
10/2014 Plenary Lecture, Annual Meeting for Brewing Society of Japan, Tokyo, Japan
02/2015 Symposium on Olfactory Circuit and Behavior (Prof. Kensaku Mori Memorial Symposium), Tokyo, Japan
07/2015 38th Annual Meeting for Japan Neuroscience Society, Kobe, Japan
09/2015 25th European Chemoreception Research Organization Congress, Istanbul, Turkey
11/2015 KAO Corporation, Utsunomiya, Japan
12/2015 National Institute of Genetics, Workshop on “Circuit Construction in the Mammalian Brain”, Mishima, Japan
05/2016 Kumamoto University, Graduate School of Pharmaceutical Sciences, Kumamoto, Japan
06/2016 17th International Symposium on Olfaction and Taste (ISOT), Yokohama, Japan
12/2016 4th “Imaging Structure and Function in the Zebrafish Brain” Conference, Max Planck Institute, Martinsried, Germany
01/2017 National Institute of Genetics, Mishima, Japan
01/2017 Tokyo Institute of Technology, Workshop on “Sense, Sensor, Sensation”, Yokohama, Japan
03/2017 Kochi University School of Medicine, Kochi, Japan
04/2017 RIKEN Open Day, Wako, Japan
06/2017 Chemical Ecology Workshop, Hakodate, Japan
10/2017 National Institute of Physiological Sciences, Workshop on Emotion, Okazaki, Japan
10/2017 Sanofi Corporation Workshop, Tokyo, Japan
11/2017 Zebrafish Neural Circuits and Behavior Symposium, Bethesda, USA
11/2017 Monell Chemical Senses Center, Philadelphia, USA
12/2017 40th Annual Meeting for the Molecular Biology Society of Japan, Kobe, Japan
02/2018 ERATO Touhara Chemosensory Signal Project Symposium, Tokyo, Japan
03/2018 International Workshop on “Memory Dynamism”, Toyama, Japan
03/2018 95th Annual Meeting for Physiological Society of Japan, Takamatsu, Japan
05/2018 8th NEURIZONS Conference “Fire, Wire, Inspire”, Max Planck Institute, Göttingen, Germany
06/2018 Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
07/2018 41st Annual Meeting for Japan Neuroscience Society, Kobe, Japan
08/2018 Okinawa Institute of Science and Technology (OIST) Developmental Neurobiology Course, Okinawa, Japan
10/2019 Naito Conference, Hokkaido, Japan
06/2020 13th Uehara International Symposium, Tokyo, Japan

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