Recruitment of Specially Appointed Researchers
Cell Simulation Research Group, Center for Frontier Biosciences【Details】(Immediately after hiring)The Cell Simulation Research Group of the Center for Frontier
Biosciences is engaged in research and development of cellular modeling and simulation, andresearch on the principles and theories of life system operation by utilizing them. This positionis open to anyone who is interested in working with our group members to elucidate thefundamental principles and mathematical mechanisms of living systems.
(Scope of change)Services provided by the National Institutes of Natural Sciences.
Theoretical studies in the life sciences have revealed mathematical insights, such as thegeneration of Turing patterns in reaction-diffusion systems. Fundamental mechanisms andstructures that interconnect between bioinformatic functional networks (e.g., transcription,metabolism and signal transduction) and physical properties (e.g., viscosity, temperature, andrefractive index) of living systems, however, still remain unclear. The living system
synchronizes microscopic biological phenomena with macroscopic phenomena, and theinteraction of these phenomena makes it a single system. By exploring the fundamental
principles underlying such cross-correlative interactions, we aim to tackle the fundamentalquestion, "What is life?”.
Conventional cell modeling based on systems biology approaches has built a foundation forunderstanding complex cellular systems by mathematically modeling life functions such astranscription, metabolism, and signal transduction. In past studies of systems biology, such as
whole-cell modeling of Escherichia coli and Mycoplasma, modeling focused on thefunctionality of connecting various biomolecular networks has been mainly conducted [AhnHorst, T. et al NPJ Syst. Biol. Appl. (2022); Karr, J. et al. Cell (2012); Tomita, M. et alBioinform. (1999)]. However, cells are not just aggregates of biomolecular networks; they also
contain governing equations and various physical quantities derived from thermology, optics,fluid dynamics, statistical mechanics, and quantum biology. Cells exist as a single life system
by simultaneously having correlation between biomolecular networks and various physicalproperties of cellular interiors. In this laboratory, we are developing not only cell modelingand simulation platforms based on systems biology approaches but also new cell modelingmethods that can simultaneously handle biological information as well as physical information
based on physical laws and governing equations (e.g., heat conduction equations and waveequations) that should be established inside cells.
Below are examples of research themes, but proposals based on your own intellectual curiosity
are also welcome:• Modeling of intercellular transport processes of Dendra2 in Physcomitrella patens
protonemata• Implementation of phase retrieval algorithms in phase-contrast/differential interference
contrast microscope images• Numerical simulation of the phase transport equation and its application

The Center for Frontier Biosciences is an Inter-University Research Institute located inOkazaki, Aichi Prefecture. The Institute for Physiological Sciences, the Institute for BasicBiology, and the Institute for Molecular Science are also located on the same campus andconduct research in collaboration with each other. The research center and the three research
institutes are equipped with a full range of advanced equipment and shared instruments, andare in an ideal environment to promote collaborative research with other research groups,
especially with experimentalists in the biological/medical sciences, so that they canconcentrate on their research. We encourage our researchers to advance not only their research
projects but also their careers.
Cell Simulation Research Group:https://www.excells.orion.ac.jp/en/research-group/cell-modeling-and-simulation【Eligibility】
Doctoral degree or expected to obtain by the date of employment.
【Number of applicants】
Specially Appointed Researchers/Postdoctoral Fellows: 1【Place of employment】(Immediately after hiring) Cell Simulation Research Group, Center for the Exploration ofLife Science(Scope of change)Location determined by the National Institutes of Natural Sciences【Work type】
Full-time (with term of office)【Term of office】
1 year (extension possible until 2027)(Workload at the end of the contract period - Worker's work performance and attitude Worker's ability and engagement
The renewal will be determined based on the progress of the work (project) in progress).
【Treatment】
Salary: Salary will be based on an annual salary scale. (Determined based on work historyand education)
Insurance, etc.: Mutual aid association of the Ministry of Education, Culture, Sports, Scienceand Technology, unemployment insurance, workers' accident compensation insurance
Other matters shall be in accordance with the employment regulations of the Organization.
【Application period】

Applications will be closed as soon as a suitable candidate is found. Please contact us first bye-mail (see below).
【How to apply】
Please send the following documents as email attachments(1) Curriculum vitae (any format, photo attached, e-mail address provided)(2) Research and Achievement List(3) pdf of major papers(4) Summary of research to date and future aspirations(5) Contact information for at least one person whose opinion can be sought about the person【Selection Details】
After screening of documents, interviews will be conducted in person or via web conference.
The results will be notified by e-mail.
【Inquiries and documents should be sent to】〒444-8787
5-1 Aza Higashiyama, Myodaiji-cho, Okazaki-shi, Aichi, Japan
Inter-University Research Institute for Natural Sciences
Cell Simulation Research Group, Center for Frontier Biosciences
Masaki Watanabe
m-watabe@nibb.ac.jp
If you have any questions regarding this application, please do not hesitate to contact us bye-mail.