The World Anti-Doping CodeTHE 2015
PROHIBITED LISTINTERNATIONAL
STANDARD
The official text of the Prohibited List shall be maintained by WADA and shall be
published in English and French. In the event of any conflict between the English
and French versions, the English version shall prevail.

This List shall come into effect on 1 January 2015

The 2015 Prohibited List
20 September 2014

THE 2015 PROHIBITED LISTWORLD ANTI-DOPING CODE
Valid 1 January 2015

In accordance with Article 4.2.2 of the World Anti-Doping Code,all Prohibited Substances shall be considered as “SpecifiedSubstances” except Substances in classes S1, S2, S4.4, S4.5,
S6.a, and Prohibited Methods M1, M2 and M3.

SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES(IN- AND OUT-OF-COMPETITION)

PROHIBITED SUBSTANCES
S0. NON-APPROVED SUBSTANCES
Any pharmacological substance which is not addressed by any of thesubsequent sections of the List and with no current approval by any
governmental regulatory health authority for human therapeutic use (e.gdrugs under pre-clinical or clinical development or discontinued, designerdrugs, substances approved only for veterinary use) is prohibited at alltimes.
S1. ANABOLIC AGENTS
Anabolic agents are prohibited.
1.

Anabolic Androgenic Steroids (AAS)

a. Exogenous* AAS, including:1-androstenediol (5α-androst-1-ene-3β,17β-diol ); 1-androstenedione (5αandrost-1-ene-3,17-dione); bolandiol (estr-4-ene-3β,17β-diol ); bolasterone;boldenone;boldione(androsta-1,4-diene-3,17-dione);calusterone;

The 2015 Prohibited List
20 September 20142clostebol;
danazol([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol);dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta1,4-dien-3-one);desoxymethyltestosterone (17α-methyl-5α-androst-2-en17β-ol);
drostanolone;
ethylestrenol(19-norpregna-4-en-17α-ol);fluoxymesterone;
formebolone;furazabol(17α-methyl[1,2,5]oxadiazolo[3',4':2,3]-5α-androstan-17β-ol);gestrinone;
4hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one); mestanolone;
mesterolone; metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3one); metenolone; methandriol; methasterone (17β-hydroxy-2α,17αdimethyl-5α-androstan-3-one);methyldienolone(17β-hydroxy-17αmethylestra-4,9-dien-3-one);methyl-1-testosterone(17β-hydroxy-17αmethyl-5α-androst-1-en-3-one); methylnortestosterone (17β-hydroxy-17αmethylestr-4-en-3-one); methyltestosterone; metribolone (methyltrienolone,17β-hydroxy-17α-methylestra-4,9,11-trien-3-one); mibolerone; nandrolone;
19-norandrostenedione (estr-4-ene-3,17-dione); norboletone; norclostebol;
norethandrolone;
oxabolone;oxandrolone;
oxymesterone;
oxymetholone;
prostanozol(17β-[(tetrahydropyran-2-yl)oxy]-1'Hpyrazolo[3,4:2,3]-5α-androstane); quinbolone; stanozolol; stenbolone; 1testosterone (17β-hydroxy-5α-androst-1-en-3-one); tetrahydrogestrinone(17-hydroxy-18a-homo-19-nor-17α-pregna-4,9,11-trien-3-one);
trenbolone(17β-hydroxyestr-4,9,11-trien-3-one);and other substances with a similar chemical structure or similar biologicaleffect(s).
b. Endogenous** AAS when administered exogenously:
Androstenediol (androst-5-ene-3β,17β-diol); androstenedione (androst-4ene-3,17-dione);dihydrotestosterone(17β-hydroxy-5α-androstan-3-one);prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one);
testosterone;
and their metabolites and isomers, including but not limited to:
5α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane3β,17α-diol;
5α-androstane-3β,17β-diol;5β-androstane-3α,17β-diol;
androst-4-ene-3α,17α-diol; androst-4-ene-3α,17β-diol; androst-4-ene3β,17α-diol;
androst-5-ene-3α,17α-diol;
androst-5-ene-3α,17β-diol;
androst-5-ene-3β,17α-diol; 4-androstenediol (androst-4-ene-3β,17β-diol);
5-androstenedione (androst-5-ene-3,17-dione); androsterone (3β-hydroxy5α-androstan-17-one);
epi-dihydrotestosterone;
epitestosterone;
etiocholanolone; 7α-hydroxy-DHEA; 7β-hydroxy-DHEA; 7-keto-DHEA; 19norandrosterone; 19-noretiocholanolone.

2. Other Anabolic Agents
Including, but not limited to:
Clenbuterol, selective androgen receptor modulators
andarine and ostarine), tibolone, zeranol and zilpaterol.
The 2015 Prohibited List
20 September 2014

(SARMs,e.g.

3For purposes of this section:* “exogenous” refers to a substance which is not ordinarily produced by the bodynaturally.
** “endogenous” refers to a substance which is ordinarily produced by the bodynaturally.

S2.
PEPTIDE
HORMONES,SUBSTANCES AND MIMETICSGROWTH

FACTORS,RELATEDThe following substances, and other substances with similar chemical structure orsimilar biological effect(s), are prohibited:
1. Erythropoietin-Receptor agonists:
1.1
Erythropoiesis-Stimulating
Agents(ESAs)
includinge.g.
darbepoietin (dEPO); erythropoietins (EPO); EPO-Fc; EPO-mimetic
peptides (EMP), e.g. CNTO 530 and peginesatide; and methoxy
polyethylene glycol-epoetin beta (CERA);
1.2
Non-erythropoietic EPO-Receptor
asialo EPO and carbamylated EPO;

agonists,e.g.

ARA-290,

2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt and FG-4592; andHIF activators, e.g. argon, xenon;
3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and theirreleasing factors, e.g. buserelin, gonadorelin and triptorelin, in males;
4. Corticotrophins and their releasing factors, e.g corticorelin;
5. Growth Hormone (GH) and its releasing factors including Growth Hormone
Releasing Hormone (GHRH) and its analogues, e.g. CJC-1295, sermorelin
and tesamorelin; Growth Hormone Secretagogues (GHS), e.g. ghrelinand ghrelin mimetics, e.g. anamorelin and ipamorelin; and GH-Releasing
Peptides (GHRPs), e.g. alexamorelin, GHRP-6, hexarelin and pralmorelin(GHRP-2).
Additional prohibited growth factors:
Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF);
Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano
Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF);
Vascular-Endothelial Growth Factor (VEGF) and any other growth factor
The 2015 Prohibited List
20 September 20144

affecting muscle, tendon or ligament protein synthesis/degradation,vascularisation, energy utilization, regenerative capacity or fibre typeswitching.

S3. BETA-2 AGONISTSAll beta-2 agonists, including all optical isomers, e.g. d- and l- whererelevant, are prohibited.
Except:

Inhaled salbutamol (maximum 1600 micrograms over 24 hours);

Inhaled formoterol (maximum delivered dose 54 micrograms over 24hours); and

Inhaled salmeterol in accordance with the manufacturers’ recommended
therapeutic regimen.

The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol inexcess of 40 ng/mL is presumed not to be an intended therapeutic use of thesubstance and will be considered as an Adverse Analytical Finding (AAF) unlessthe Athlete proves, through a controlled pharmacokinetic study, that theabnormal result was the consequence of the use of the therapeutic inhaled dose
up to the maximum indicated above.

S4. HORMONE AND METABOLIC MODULATORSThe following hormones and metabolic modulators are prohibited:
1. Aromatase inhibitors including, but not limited to: aminoglutethimide;
anastrozole; androsta-1,4,6-triene-3,17-dione (androstatrienedione);
4-androstene-3,6,17 trione (6-oxo); exemestane; formestane;
letrozole and testolactone.
2. Selective estrogen receptor modulators (SERMs) including, but notlimited to: raloxifene; tamoxifen and toremifene.
3. Other anti-estrogenic substances including,clomiphene; cyclofenil and fulvestrant.

butnotlimited

to:4. Agents modifying myostatin function(s) including, but not limited, to:myostatin inhibitors.

The 2015 Prohibited List
20 September 20145

5. Metabolic modulators:
5.1
Activators of the AMP-activated protein kinase (AMPK), e.g.
AICAR; and Peroxisome Proliferator Activated Receptor δ (PPARδ)
agonists, e.g. GW 1516;
5.2

Insulins;

5.3

Trimetazidine.

S5. DIURETICS AND MASKING AGENTS
The following diuretics and masking agents are prohibited, as are othersubstances with a similar chemical structure or similar biological effect(s).
Including, but not limited to:Desmopressin; probenecid; plasma expanders, e.g. glycerol andintravenous administration of albumin, dextran, hydroxyethyl starch
and mannitol.

Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone;
etacrynicacid;furosemide;
indapamide;
metolazone;
spironolactone; thiazides, e.g. bendroflumethiazide, chlorothiazide
and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan.

Except:Drospirenone; pamabrom; and topical dorzolamide and brinzolamide.

Local administration of felypressin in dental anaesthesia.

The detection in an Athlete’s Sample at all times or In-Competition, as applicable,of any quantity of the following substances subject to threshold limits: formoterol,salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in
conjunction with a diuretic or masking agent, will be considered as an Adverse
Analytical Finding unless the Athlete has an approved TUE for that substance inaddition to the one granted for the diuretic or masking agent.

The 2015 Prohibited List
20 September 2014

6

PROHIBITED METHODS
M1. MANIPULATION OF BLOOD AND BLOOD COMPONENTS
The following are prohibited:
1.

The Administration or reintroduction of any quantity of autologous, allogenic(homologous) or heterologous blood, or red blood cell products of any origin
into the circulatory system.

2.

Artificially enhancing the uptake, transport or delivery of oxygen.
Including, but not limited to:
Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin
products, e.g. haemoglobin-based blood substitutes and microencapsulated
haemoglobin products, excluding supplemental oxygen.

3.

Any form of intravascular manipulation of the blood or blood components byphysical or chemical means.

M2. CHEMICAL AND PHYSICAL MANIPULATION
The following are prohibited:
1.

Tampering, or Attempting to Tamper, to alter the integrity and validity ofSamples collected during Doping Control.
Including, but not limited to:Urine substitution and/or adulteration, e.g. proteases.

2.

Intravenous infusions and/or injections of more than 50 mL per 6 hour period
except for those legitimately received in the course of hospital admissions,
surgical procedures or clinical investigations.

M3. GENE DOPING
The following, with the potential to enhance sport performance, are prohibited:
1.

The transfer of polymers of nucleic acids or nucleic acid analogues;

2.

The use of normal or genetically modified cells.

The 2015 Prohibited List
20 September 2014

7

SUBSTANCES AND METHODSPROHIBITED IN-COMPETITION
In addition to the categories S0 to S5 and M1 to M3 defined above,
the following categories are prohibited In-Competition:

PROHIBITED SUBSTANCES
S6. STIMULANTS
All stimulants, including all optical isomers, e.g. d- and l- where relevant, areprohibited.
Stimulants include:
a: Non-Specified Stimulants:
Adrafinil; amfepramone; amfetamine; amfetaminil; amiphenazole;
benfluorex;
benzylpiperazine;
bromantan;
clobenzorex;
cocaine;cropropamide; crotetamide; fencamine; fenetylline; fenfluramine;fenproporex; fonturacetam [4-phenylpiracetam (carphedon)]; furfenorex;
mefenorex;
mephentermine;mesocarb;
metamfetamine(d-);
pmethylamphetamine; modafinil; norfenfluramine; phendimetrazine;
phentermine; prenylamine and prolintane.
A stimulant not expressly listed in this section is a Specified Substance.
b: Specified Stimulants.
Including, but not limited to:
Benzfetamine; cathine**; cathinone and its analogues, e.g. mephedrone,
methedrone, and α- pyrrolidinovalerophenone; dimethylamphetamine;ephedrine***; epinephrine**** (adrenaline); etamivan; etilamfetamine;
etilefrine; famprofazone; fenbutrazate; fencamfamin; heptaminol;hydroxyamfetamine(parahydroxyamphetamine);isometheptene;
levmetamfetamine; meclofenoxate; methylenedioxymethamphetamine;
methylephedrine***;methylhexaneamine(dimethylpentylamine);
methylphenidate; nikethamide; norfenefrine; octopamine; oxilofrine(methylsynephrine); pemoline; pentetrazol; phenethylamine and its
derivatives;
phenmetrazine;
phenpromethamine;
propylhexedrine;
pseudoephedrine*****;
selegiline;
sibutramine;
strychnine;tenamfetamine (methylenedioxyamphetamine), tuaminoheptane;

The 2015 Prohibited List20 September 20148

and other substances with a similar chemical structure or similar biologicaleffect(s).
Except:Imidazole derivatives for topical/ophthalmic use and those stimulants included in
the 2015 Monitoring Program*.
*

Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine,pipradrol, and synephrine: These substances are included in the 2015
Monitoring Program, and are not considered Prohibited Substances.

**Cathine: Prohibited when its concentration in urine is greater than 5micrograms per milliliter.

***Ephedrine and methylephedrine: Prohibited when the concentration ofeither in urine is greater than 10 micrograms per milliliter.

****

Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal,
ophthalmologic, or co-administration with local anaesthetic agents.

*****

Pseudoephedrine: Prohibited when its concentration in urine is greaterthan 150 micrograms per milliliter.

S7. NARCOTICS
Prohibited:
Buprenorphine; dextromoramide; diamorphine (heroin); fentanyl and its
derivatives; hydromorphone; methadone; morphine; oxycodone;oxymorphone; pentazocine and pethidine.

S8. CANNABINOIDS
Prohibited:

Natural, e.g. cannabis, hashish and marijuana, or synthetic
9-tetrahydrocannabinol (THC).
Cannabimimetics, e.g. “Spice”, JWH-018, JWH-073, HU-210.

S9. GLUCOCORTICOIDS
All glucocorticoids are prohibited when administered by oral, intravenous,intramuscular or rectal routes.

The 2015 Prohibited List
20 September 2014

9

SUBSTANCES PROHIBITED IN PARTICULARSPORTSP1. ALCOHOL
Alcohol (ethanol) is prohibited In-Competition only, in the following sports.
Detection will be conducted by analysis of breath and/or blood. The dopingviolation threshold is equivalent to a blood alcohol concentration of 0.10 g/L.
Air Sports (FAI)
Archery (WA)
Automobile (FIA) Motorcycling (FIM) Powerboating (UIM)

P2. BETA-BLOCKERS
Beta-blockers are prohibited In-Competition only, in the following sports, andalso prohibited Out-of-Competition where indicated.








Archery (WA)*
Automobile (FIA)Billiards (all disciplines) (WCBS)
Darts (WDF)
Golf (IGF)
Shooting (ISSF, IPC)*
Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe andsnowboard halfpipe/big air
Underwater sports (CMAS) in constant-weight apnoea with or without fins,
dynamic apnoea with and without fins, free immersion apnoea, Jump Blueapnoea, spearfishing, static apnoea, target shooting and variable weight
apnoea.
*Also prohibited Out-of-Competition

Including, but not limited to:
Acebutolol; alprenolol; atenolol; betaxolol; bisoprolol; bunolol; carteolol;
carvedilol; celiprolol; esmolol; labetalol; levobunolol; metipranolol;
metoprolol; nadolol; oxprenolol; pindolol; propranolol; sotalol andtimolol.

The 2015 Prohibited List
20 September 201410