September 19, 20092010 Prohibited List
Summary of Major Modifications
INTRODUCTORY PARAGRAPH

The introductory sentence on the use of drugs limited to medically justifiedindications has been deleted.

The reference to Specified Substances has been amended in accordance withchanges introduced in section S2.

SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OFCOMPETITION)
S1: Anabolic AgentsThe International Nonproprietary Name (INN) for methyltrienolone has been
included (metribolone)Comment S1.1b, including revisions, is addressed in another WADA document(Technical Document MRPL).

S2. Peptide Hormones, Growth Factors and Related Substances

In order to better define the substances within this category, the title has beenrevised to “Peptide Hormones, Growth Factors and Related Substances”.

To reflect the growing number of new erythropoeisis-stimulating substances
available, methoxy polyethylene glycol-epoetin beta (CERA) has been added as
an example.

The issue of growth factors enhancing certain functions was addressed in moredetail. Additional examples of growth factors affecting muscle, tendon orligament protein synthesis/degradation, vascularisation, energy utilization,regenerative capacity or fibre type switching [e.g. Platelet-derived GrowthFactor (PDGF), Fibroblast Growth Factors (FGFs), Vascular-Endothelial Growth
Factor (VEGF), Hepatocyte Growth Factor (HGF)] were included.

The status of Platelet-derived preparations (e.g. Platelet Rich Plasma, “bloodspinning”) has been clarified.

Comment S2 is addressed in another WADA document (Technical DocumentMRPL).

1S3. Beta-2 Agonists
The use of salbutamol and salmeterol by inhalation no longer requires a TUE but
a declaration of Use.

It is specified that the maximum dose for the controlled pharmacokinetic study
cannot exceed the maximum therapeutic dose for inhaled salbutamol (1600µg/day).

S4. Hormone antagonists and ModulatorsTwo examples of aromatase inhibitors, androstene-3,6,17 trione (6-oxo) andandrosta-1,4,6-triene-3,17-dione (androstatrienedione) have been added inview of their wide availability as components of nutritional supplements.

S5. Diuretics and Other masking AgentsThe status of glycerol (oral and intravenous) as a plasma expander was clarified
and is now included as another example.

The non-prohibited status of pamabrom was clarified because it is a weak
diuretic largely available as a combined over-the-counter medication for premenstrual/menstrual symptoms.

PROHIBITED METHODS
M1. Enhancement of Oxygen Transfer
Supplemental oxygen is no longer prohibited.

M2. Chemical and Physical Manipulation
 Proteases have been added as an example of sample adulteration.
 The status of intravenous infusions has been reviewed and now reads:“Intravenous infusions are prohibited except for those legitimately received in
the course of hospital admissions or clinical investigations.”
M3. Gene Doping

For clarification purposes the gene doping definition was reworded and split into
2 points.

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SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION
S6. Stimulants
Three stimulants, namely benfluorex, prenylamine, both known to metabolize tonon-specified stimulants (amphetamine or norfenfluramine) as well as
methylhexeneamine, a non-therapeutic substance, were added to the closed listof non-specified stimulants.

 Until 2003, the stimulant pseudoephedrine had been prohibited in sports with athreshold of 25 μg/mL. Pseudoephedrine has been included in the Monitoring
Program since 2004. Results from the Monitoring Program over the past 5years have shown a sustained increase in urinary concentrations ofpseudoephedrine. In addition, there is clear evidence of abuse in some sports
and some regions which show clusters of samples with high pseudoephedrine
concentrations many times in excess of concentrations normally found.
Furthermore, the available literature demonstrates scientific proof of its
performance enhancing effects at certain doses. Therefore, the List Committee
has reintroduced pseudoephedrine as a specified stimulant in the 2010
Prohibited List at a urinary threshold of 150 µg/mL based on the results fromcontrolled excretion studies as well as the literature. Given the wide availabilityof pseudoephedrine-containing medicines, WADA recommends that thereintroduction of pseudoephedrine is supported by active information/education
campaign by all stakeholders.
Although pseudoephedrine is now prohibited, it will remain in the Monitoring
Program for urinary concentrations below 150 µg/mL.

S8. Cannabinoids
It is clarified that synthetic cannabinoids are covered by this section.

SUBSTANCES PROHIBITED IN PARTICULAR SPORTS
P1. Alcohol and P2. Beta-blockers
As the responsibility for testing in the sports of Boules and Archery has beentransferred from the International Paralympic Committee (IPC) to the World
Bowling Federation and the International Archery Federation (FITA),
respectively, references to the IPC have been deleted.

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