Curriculum Vitae
2018. 9. 18

Masanori MATSUZAKI
Position
Professor
Department of Physiology, Graduate School of Medicine, The University of Tokyo
Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Phone: -81-3-5841-3471; E-mail: mzakim [at] m.u-tokyo.ac.jp
Team Leader
Brain Functional Dynamics Collaboration Laboratory, RIKEN Center for Brain Science
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: masanori.matsuzaki [at] riken.jp
Education
2001

Ph.D. (Medicine), Graduate School of Medicine, The University of Tokyo, Japan1996

M. Sci., Graduate School of Science, The University of Tokyo, Japan1994

B. Sci., Department of Biophysics and Biochemistry, School of Science, The University of Tokyo, Japan

Academic Employment
2018-

Team leader, RIKEN Center for Brain Science, Japan

2016-Professor, The University of Tokyo, Japan

2010-2016

Professor, National Institute for Basic Biology, Japan, SOKENDAI, Japan

2008-2010

Associate Professor, The University of Tokyo, Japan

2005-2007

Assistant Professor, The University of Tokyo, Japan

2002-2005

Assistant Professor, National Institute for Physiological Sciences, JapanAwards
2017 JSPS (Japan Society for the Promotion of Science) Prize, Japan
2005 The Young Scientists' Prize, The Commendation for Science and Technology by the Minister of Education,Culture, Sports, Science and Technology, Japan
2005 Young Investigator Award, Japan Neuroscience SocietyPublications
1.

Terada S., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M. Super-wide-field two-photon imaging witha micro-optical device moving in post-objective space. Nature Communications 9, 3550, 2018.

2.

Tanaka Y.H., Tanaka Y.R., Kondo M., Terada S., Kawaguchi Y., and Matsuzaki M. Thalamocortical axonal
activity in motor cortex exhibits layer-specific dynamics during motor learning. Neuron 100, AOP, 2018.

3.

Yoshida E., Terada S., Tanaka Y.H., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M. Wide-field
calcium imaging of mouse thalamocortical synapses with an 8 K ultra-high-definition camera. ScientificReports 8, 8324, 2018.

4.

Ebina, T., Masamizu Y., Tanaka Y.R., Watakabe A., Hirakawa R., Hirayama Y., Hira R., Terada S.,Koketsu

D., Hikosaka K., Mizukami H., Nambu A., Sasaki E., Yamamori T., and Matsuzaki M. Two-photon imagingof neuronal activity in motor cortex of marmosets during upper-limb movement tasks. Nature
Communications 9, 1879, 2018.
5.

Endo K., Ishigaki S., Masamizu Y., Fujioka Y., Watakabe A., Yamamori T., Hatanaka N., Nambu A., Okado
H., Katsuno M., Watanabe H., Matsuzaki M., and Sobue G. Silencing of FUS in the common marmoset(Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA.
Neuroscience Research 130, 56-64, 2018.

6.

Kondo M., Kobayashi K., Ohkura M., Nakai J., and Matsuzaki M. Two-photon calcium imaging of themedial prefrontal cortex and hippocampus without cortical invasion. eLife 6, e26839, 2017.

7.

Terada S., Matsubara D., Onodera K., Matsuzaki M., Uemura T., and Usui T. Neuronal processing of noxious
thermal stimuli mediated by dendritic Ca2+ influx in Drosophila sensory neurons. eLife 5, e12959, 2016.

8.

Sadakane O., Masamizu Y., Watakabe A., Terada S., Ohtsuka M., Takaji M., Mizukami H., Ozawa K.,Kawasaki H., Matsuzaki M., and Yamamori T. Long-term two-photon calcium imaging of neuronal
populations with subcellular resolution in adult non-human primates. Cell Reports 13, 1989-1999, 2015.

9.

Hira R., Terada S., Kondo M., and Matsuzaki M. Distinct functional modules for discrete and rhythmicforelimb movements in the mouse motor cortex. Journal of Neuroscience 35, 13311-13322, 2015.

10. Hira R., Ohkubo F., Masamizu Y., Ohkura M., Nakai J., Okada T., and Matsuzaki M.
Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron
operant conditioning. Nature Communications 5, 5551, 2014.
11. Masamizu Y., Tanaka Y.R., Tanaka Y.H., Hira R., Ohkubo F., Kitamura K., Isomura Y., Okada T., andMatsuzaki M. Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.
Nature Neuroscience 17, 987-994, 2014.
12. Asrican B., Augustine G.J., Berglund K., Chen S.,Chow N., Deisseroth K., Feng G., Gloss B., Hira R.,

Hoffmann C., Kasai H., Katarya M., Kim J., Kudolo J., Lee L., Lo S., Mancuso J., Matsuzaki M., NakajimaR., Qui L., Tan G., Tang Y., Ting J.T., Tsuda S., Wen L., Zhang X, and Zhao S. Next-generation transgenic
mice for optogenetic analysis of neural circuits. Frontiers in Neural Circuits 7, 160, 2013.
13. Hayama T., Noguchi J., Watanabe S., Takahashi N., Hayashi-Takagi A., Ellis-Davies G.C.R., Matsuzaki M.,
and Kasai H. GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.
Nature Neuroscience 16, 1409-1416, 2013.
14. Hira R., Ohkubo F., Tanaka Y.R., Masamizu Y., Augustine G.J., Kasai H., and Matsuzaki M. In vivo
optogenetic tracing of functional corticocortical connections between motor forelimb areas. Frontiers in
Neural Circuits 7, 55, 2013.

15. Hira R., Ohkubo F., Ozawa K., Isomura Y., Kitamura K., Kano M., Kasai H., and Matsuzaki M.
Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary
movement. Journal of Neuroscience 33, 1377-1390, 2013.
16. Kimura R., Saiki A., Fujiwara-Tsukamoto Y., Ohkubo F., Kitamura K., Matsuzaki M., Sakai Y., and Isomura
Y. Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents.
Journal of Neurophysiology 108, 1781-1792, 2012.
17. Ako R., Wakimoto M., Ebisu H., Tanno K., Hira R., Kasai H., Matsuzaki M., and Kawasaki H. Simultaneous
visualization of multiple neuronal properties with single-cell resolution in the living rodent brain. Molecularand Cellular Neuroscience 48, 246-257, 2011.
18. Kanemoto Y., Matsuzaki M., Morita S., Hayama T., Noguchi J., Senda N., Momotake A., Arai T., and Kasai
H. Spatial distributions of GABA receptors and local inhibition of Ca2+ transients studied with GABA
uncaging in the dendrites of CA1 pyramidal neurons. PLoS One 6, e22652, 2011.
19. Noguchi J., Nagaoka A., Watanabe S., Ellis-Davies G.C.R., Kitamura K., Kano M., Matsuzaki M., and Kasai
H. In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines
in the neocortex of adult mice. Journal of Physiology 589, 2447-2457, 2011.
20. Matsuzaki M., Ellis-Davies G.C.R., Kanemoto Y. and Kasai H. Simultaneous two-photon activation ofpresynaptic cells and calcium imaging in postsynaptic dendritic spines. Neural Systems & Circuits 1, 2, 2011.
21. Matsuzaki M., Hayama T., Kasai H. and Ellis-Davies G.C.R. Two-photon uncaging of γ-aminobutyric acid inintact brain tissue. Nature Chemical Biology 6, 255-257, 2010.
22. Obi N., Momotake A., Kanemoto Y., Matsuzaki M., Kasai H. and Arai T.
1-Acyl-5-methoxy-8-nitro-1,2-dihydroquinoline: A biologically useful photolabile precursor of carboxylic
acids. Tetrahedron letters 51. 1642-1647, 2010.
23. Kantevari S., Matsuzaki M., Kanemoto Y., Kasai H. and Ellis-Davies G.C.R. Two-color, two-photon
uncaging of glutamate and GABA. Nature Methods 7, 123-125, 2010.
24. Hira R., Honkura N., Noguchi J., Maruyama Y., Augustine G.J., Kasai H. and Matsuzaki M. Transcranial
optogenetic stimulation for functional mapping of the motor cortex. Journal of Neuroscience Methods 179,258-263, 2009.
25. Yasumatsu N., Matsuzaki M., Miyazaki T., Noguchi J. and Kasai H. Principles of long-term dynamics ofdendritic spines. Journal of Neuroscience 28, 13592-13608, 2008.
26. Honkura N., Matsuzaki M., Noguchi J., Ellis-Davies G.C.R. and Kasai H. The subspine organization of actin
fibers regulates the structure and plasticity of dendritic spines. Neuron 57, 719-729, 2008.
27. Tanaka J., Horiike Y., Matsuzaki M., Miyazaki T., Ellis-Davies G.C.R. and Kasai H. Protein-synthesis andneurotrophin dependent structural plasticity of single dendritic spines. Science 319, 1683-1687, 2008.
28. Matsuzaki M., Ellis-Davies G.C.R. and Kasai H. High-resolution mapping of synaptic connections bytwo-photon macro photolysis of caged glutamate. Journal of Neurophysiology 99, 1535-1544, 2008.
29. Ellis-Davies G.C.R., Matsuzaki M., Paukert M., Kasai H. and Bergles D.E.
4-carboxymethoxy-5,7-dinitroindolinyl-glu: an improved caged glutamate for expeditious ultraviolet and2-photon photolysis in brain slices. Journal of Neuroscience 27, 6601-6604, 2007.

30. Wang H., Peca J., Matsuzaki M., Matsuzaki K., Noguchi J., Qiu L., Wang D., Zhang F., Boyden E.,
Deisseroth K., Kasai H., Hall W.C., Feng G., and Augustine G.J. High-speed mapping of synaptic
connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proceedings of the National
Academy of Sciences of the United States of America 104, 8143-8148, 2007.
31. Matsuzaki M. Factors critical for the plasticity of dendritic spines and memory storage. Neuroscience
Research 57, 1-9, 2007.
32. Ohkura M., Matsuzaki M., Kasai H., Imoto K. and Nakai J. Genetically encoded bright Ca2+ probe applicablefor dynamic Ca2+ imaging of dendritic spines. Analytical Chemistry 77, 5861-5869, 2005.
33. Noguchi J., Matsuzaki M., Ellis-Davies G.C.R. and Kasai H. Spine-neck geometry determines
NMDA-receptor dependent Ca2+ signaling in dendrites. Neuron 46, 609-622, 2005.
34. Tanaka J., Matsuzaki M., Tarusawa E., Momiyama A., Molnar E., Kasai H. and Shigemoto R. Number anddensity of AMPA receptors in single synapses in immature cerebellum. Journal of Neuroscience 25, 799-807,
2005.
35. Sakai N., Tsubokawa H., Matsuzaki M., Kajimoto T., Takahashi E., Ren Y., Ohmori S., Shirai Y.,
Matsubayashi H., Chen J., Duman RS., Kasai H. and Saito N. Propagation of γPKC translocation along thedendrites of Purkinje cell in γPKC-GFP transgenic mice. Genes to Cells 9, 945-57, 2004.
36. Matsuzaki M., Honkura N., Ellis-Davies G.C.R. and Kasai H. Structural basis of long-term potentiation insingle dendritic spines. Nature 429, 761-766 2004.
37. Kasai H., Matsuzaki M., Noguchi J., Yasumatsu N. and Nakahara H. Structure-stability-function relationshipsof dendritic spines. Trends in Neurosciences 26, 360-368, 2003.
38. Matsuzaki M., Ellis-Davies G.C.R., Nemoto T., Miyashita Y., Iino M. and Kasai H. Dendritic spine geometryis critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nature Neuroscience 4,1086-1092, 2001.
39. Matsuzaki M. and Saigo K. hedgehog signaling independent of engrailed and wingless required for post-S1
neuroblast formation in Drosophila CNS. Development 122, 3567-3575, 1996.
40. Higashijima S., Shishido E., Matsuzaki M. and Saigo K. eagle, a member of the steroid receptor genesuperfamily is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in theDrosophila CNS. Development 122, 527-536, 1996.