ඳ჻ቇ૏⺰ᢥክᩏⷐᣦᚑ く ᄢ ቇቇ૏ⷙೣ㧔ᤘ๺  ᐕ㧠᦬㧝ᣣᢥㇱ⋭઎╙㧥ภ㧕╙㧤᧦ߩⷙቯߦࠃࠆ౏⴫ࠍ⋡⊛ߣߒߡ㧘ᧄቇߦ߅޿ߡඳ჻ߩቇ૏ࠍ᝼ਈߒߚ⠪ߩ⺰ᢥክᩏߩⷐᣦࠍᰴߩߣ߅ࠅ⊓タߔࠆ‫ޕ‬ቇ૏⸥⇟ภߦઃߒߚ↲ߪᧄቇቇ૏ⷙೣ╙㧟᧦╙㧟㗄ߦࠃࠆ߽ߩߢ޽ࠆ‫ޕ‬᳁     ฬ  GOUDARZINEMATI, Alirezaቇ ૏ ߩ ⒳ 㘃  ඳ჻㧔Ꮏቇ㧕ቇ ૏ ⸥ ⇟ ภ  ↲╙ภቇ૏᝼ਈᐕ᦬ᣣ   ᐕ㧟᦬  ᣣቇ૏᝼ਈߩ↪ઙ  ቇ૏ⷙೣ╙㧠᧦╙㧝㗄⹥ᒰ⠪ቇ ૏ ⺰ ᢥ 㗴 ⋡  Multi-source Streaming Models for Mobile P2P Overlay Networks.⺰ ᢥ ክ ᩏ ᆔ ຬ  ਥᩏ Ṛᴛ  ⺈ᆔຬ ጤፒ  ቇ࡮ᩙᨋ િ৻࡮᧛਄ ੳᏆࠆ‫࡯࡝࠻ࠬߒ᦭଻ࠍ࠻ࠢࠚࠫࡉࠝ࡮ࠕࠖ࠺ࡔ࠴࡞ࡑޕ‬=⺰ᢥౝኈߩⷐᣦ?
ࡒࡦࠣ࡮ࠨ࡯ࡆࠬࠍឭଏߔࠆࡇࠕࠍㅍାࡇࠕߣߒ㧘ߎߎࠇ߹ߢߩᖱႎࠪࠬ࠹ࡓߩਛᔃߢ޽ߞߚࠢ࡜ࠗࠕࠇࠍฃߌࠆࡇࠕࠍฃାࡇࠕߣߔࠆ‫ޕ‬P2P ࠝ࡯ࡃ࡯࡟ࡦ࠻࡮ࠨ࡯ࡃ࡮ࡕ࠺࡞ߦട߃ߡ㧘ᣂߚߦࡇࠕ࡮࠷࡯࡮ࡇࠕ(P2P: peer-to-peer)ࠝ࡯ࡃ࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ߇

ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ਄ߩ‫ߩࠕࡇޟ‬⒖േ‫ࠍޠ‬㧘ᧄ⺰ᢥߢߪᐢߊ೑↪ߐࠇߡ߈ߡ޿ࠆ‫ޕ‬P2P ࡀ࠶࠻ࡢ࡯ࠢߢߪ㧘ฦࡊࡠ࠮ࠬߪኻ╬(ࡇࠕ: peer)ߢ޽ࠅ㧘ࠨ࡯ࡃ࡯ߣࠢ࡜ߡࡕ࠺࡞ൻߔࠆ‫ޕ‬⒖േߔࠆฃାࡇࠕ߇㧘ⷐ᳞ࠍḩ⿷ߔࠗࠕࡦ࠻ߩਔᣇߩᓎഀࠍṶߓࠆߎߣ߇ߢ߈ࠆ‫ޕ‬ฦࡇࠕⶄᢙߩㅍାࡇࠕ߆ࠄࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩ߇⥄ᓞ⊛ߢ޽ࠆߎߣ߆ࠄ㧘⒳‫ߩޘ‬ᖱႎ㧘․ߦࡆ࠺ࠝ㧘ࠬ࠻࡝࡯ࡒࡦࠣ࡮ࠨ࡯ࡆࠬࠍฃାߔࠆᣇᑼߦߟ޿ߡߩ㖸ჿߩࠃ߁ߥࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻߇㧘࠳࠙⎇ⓥߢ޽ࠆ‫ޕ‬ࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩ‫ޟ‬QoS ߩᄌൻ‫ߒߣޠ‬ࠆ QoS ࠍ଻㓚ߒߥ߇ࠄ㧘ࡀ࠶࠻ࡢ࡯ࠢ਄ߦಽᢔߒߚ߹ߕ㧘╙ 1 ┨ߢߪ㧘ᧄ⺰ᢥߩ⋡⊛㧘⎇ⓥߩᣇᴺ⺰㧘ࡦࡠ࡯࠼㧘ࠠࡖ࠶ࠪࡦࠣ╬ߦࠃࠅ⥄ὼ⊒↢⊛ߦⶄᢙߩࡇࠕ㑆ߦಽᢔߐࠇߡ޿ߊ․ᓽ߇޽ࠆ‫ߚ߹ޕ‬㧘ฦࡇࠕߢ․⦡ࠍㅀߴ㧘㑐ㅪ⎇ⓥߦߟ޿ߡ⺰ߒߡ޿ࠆ‫ޕ‬╙ 2 ┨ߢߪ㧘ᧄ⺰ᢥߢኻ⽎ߣߔࠆ P2P ࠪࠬ࠹ࡓߩ

ߪ㧘ࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩ৻ㇱ㧘ߐࠄߦࠨ࡯ࡆࠬຠ⾰(QoS: Quality of Service)߇ૐਅߒߚ࡟ࡊ

ࡕ࠺࡞ߦߟ޿ߡ⼏⺰ߒߡ޿ࠆ‫ࡉࠝ࡮ࠕࠖ࠺ࡔ࠴࡞ࡑޕ‬࡝ࠞ╬ߩ⒳‫ߩޘ‬ᒻᘒ߇଻ᜬߐࠇࠆ‫ߪࠕࡇޕ‬㧘ࡀ࠶࠻ࡢࠫࠚࠢ࠻ࠍ଻ᜬߒߡ޿ࠆࡇࠕࠍㅍାࡇࠕ㧘ߎࠇࠍฃା

࡯ࠢ਄ߢ૏⟎࿕ቯߩࠦࡦࡇࡘ࡯࠲ߩߺߥࠄߕ㧘៤Ꮺ┵ߒ೑↪⠪ߦ಴ജߔࠆࡇࠕࠍฃାࡇࠕߣߔࠆ‫ߩࠄࠇߎޕ‬ᧃ╬ߩ⒖േ૕ᯏེߦࠃࠅታ⃻ߐࠇߡ޿ࠆ‫⺰ᧄޕ‬ᢥߢߪ㧘
P2P ࠝ࡯ࡃ࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ਄ߦಽᢔߒߚࡑ࡞࠴ࡔ

ࡇࠕߪ㧘P2P ࠝ࡯ࡃ࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ਄ߦಽᢔߒߡ

࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩࠨ࡯ࡆࠬߩਛߢ㊀ⷐߣߥߞߡࠢ਄ߩㅢାන૏ߢ޽ࠆࠝࡉࠫࠚࠢ࠻න૏ߦಽഀߐࠇ޿ࠆࠬ࠻࡝࡯ࡒࡦࠣ(streaming)࡮ࠨ࡯ࡆࠬࠍ⠨߃ࠆ‫ޕ‬ㅍାߐࠇࠆ‫ߚ߹ޕ‬㧘ࡇࠕߣߒߡ⒖േ૕ᯏེ߽⠨߃㧘ࠝߎߎߢߪ㧘ࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩ࠺࡯࠲ࠍ

࡯ࡃ࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ਄ߢߩߡࡇࠕߩ⒖േࠍ㧘ᣂߚㅪ⛯⊛ߦ߆ߟ৻ቯᤨ㑆ౝߦ㈩ㅍߔࠆߎߣ߇᳞߼ࠄࠇߦ‫ޟ‬QoS ߩᄌൻ‫࡞࠺ࡕߒߣޠ‬ൻߒߡ޿ࠆ‫ޕ‬޿ࠆ‫ߪ࠻ࠢࠚࠫࡉࠝ࡮ࠕࠖ࠺ࡔ࠴࡞ࡑޕ‬㧘ࡀ࠶࠻ࡢ࡯㧙㧙ㅍାࡇࠕౝߩࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ࠍ㧘ฃㅍାࡇࠕ߇หߓࠝࡉࠫࠚࠢ࠻න૏ࠍ౬㐳ߦㅍାߔࠆାࡇࠕߦㅍାߔࠆᣇᴺߣߒߡ㧘ࠨ࡯ࡃ㨯ࠢ࡜ࠗࠕࡦ࠻ߎߣߦࠃࠅหᦼࠍߣࠆᣇᑼࠍᣂߚߦ⠨᩺ߒߚ‫ߦࠇߎޕ‬ࡕ࠺࡞ࠍၮᧄߣߒߚන৻ㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ
(SSS: single-source streaming)ࡕ࠺࡞߇ߎࠇ߹ߢ↪

ࠃࠅ㧘ㅍାࡇࠕ߇ಾࠅᦧࠊߞߡ߽ QoS ࠍ଻㓚ߒߥ߇ࠄㅪ⛯⊛ߦࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ࠍฃାࡇࠕ޿ࠄࠇߡ߈ߚ‫ߩ࡞࠺ࡕߩߎޕ‬໧㗴ὐߣߒߡ㧘ㅍାࡇࠕ

ߦ㈩ㅍߢ߈ࠆ‫⹏ࠆࠃߦࡦ࡚ࠪ࡯࡟ࡒࡘࠪޕ‬ଔࠍⴕ޿㧘ࡏ࠻࡞ࡀ࠶ࠢߣߥࠆߎߣ߇޽ࠆ‫ߦࠇߎޕ‬ኻߒߡ㧘ᧄ⺰セߒߡ㧘ࠝࡉࠫࠚࠢ࠻න૏ߩ⚗ᄬ₸ࠍ 55㧑ૐᷫߢ߈ᢥߩ╙㧟┨ߢߪ㧘ᣂߚߦ㧘ⶄᢙߩㅍାࡇࠕߦࠃࠅࠬ࠻ࠆߎߣࠍ␜ߒߚ‫ߩ┨ᧄޕ‬ᚑᨐߪ㧘ਅ⸥ߩ⺰ᢥߣߒߡ⊒࡝࡯ࡒࡦࠣࠍⴕ߁ᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ(MSS:⴫ߒߡ޿ࠆ‫ޕ‬߇න৻᡿㓚ὐ(single point of failure)ߣߥࠅ㧘ᕈ⢻ߩmulti-source streaming)ࡕ࠺࡞ࠍ⺰ߓߡ޿ࠆ‫ޕ‬MSSฃାࡇࠕߩ⒳‫ߩޘ‬⒖േㅦᐲߦኻߒߡ㧘ᓥ᧪ߩᣇᑼߣᲧ

•ࡕ࠺࡞ࠍಽ㘃ߒ㧘ⶄᢙߩㅍାࡇࠕߩਛߢ㧘৻ߟߩㅍା

ࡇࠕߩߺ߇ㅍାࠍⴕ߁⋥೉ MSS(SMSS: serial MSS)

Overlay

MSS(PMSS: parallel MSS)ࠍᣂߚߦ⠨᩺ߒߚ‫┨ᧄޕ‬•

Goudarzinemati,“ApplicationA.,

LevelandTakizawa,

inMultimedia•

ConferenceonAdvanced

Information

NetworkingandofMobile

Goudarzinemati, A., Enokido, T., and Takizawa,M., “A Multi-Source Streaming Model for Mobile

the International Conference on Network-BasedInformation Systems (NBiS2008), Turin, Italy,

Applications

Sep. 2008, pp. 122-131.

(IEEE AINA2008) Workshops, Okinawa, March2008, pp. 319-324.

JournalPeer-to-Peer (P2P) Overlay Networks,” Proc. ofPeer-to-Peer (P2P) Networks,” Proc. of theInternational

Networks,”

Multimedia (JMM), Vol. 5, No.1, 2009, pp. 45-63.

M.,

QoS

Transmission Procedures for a Multi-Source

Streaming Model in Mobile Peer-to-Peer (P2P)

ߣ㧘ⶄᢙߩㅍାࡇࠕ߇หᤨߦㅍାࠍⴕ߁ਗ೉ߩ⎇ⓥᚑᨐߪએਅߩ⺰ᢥߣߒߡ⊒⴫ߒߡ޿ࠆ‫ޕ‬

Goudarzinemati, A. and Takizawa, M., “Data╙㧡┨ߢߪ㧘ⶄᢙߩㅍାࡇࠕ߇ਗⴕߒߡ㧘ࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩࠝࡉࠫࠚࠢ࠻න૏ࠍฃାࡇࠕᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ(MSS ࡕ࠺࡞)ߣߒߡ㧘ߦㅍାߔࠆਗ೉ᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ(PMSS)⋥೉ᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ㧔SMSS㧕ߣਗ೉ᄙࡕ࠺࡞ߦߟ޿ߡ⺰ߓߡ޿ࠆ‫ߪߢߎߎޕ‬㧘ฦㅍାࡇࠕߦㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ㧔PMSS㧕ࡕ࠺࡞߇޽ࠆ‫ޕ‬ ╙㧠┨ߢߪ㧘⋥೉ MSS(SMSS)ᣇᑼߦߟ޿ߡ⼏⺰ߒߡ޿ࠆ‫ޕ‬SMSS ࡕ࠺࡞ߢߪ㧘ⶄᢙߩㅍାࡇࠕߩߥ߆ߢ㧘ฦᤨὐߢฃାࡇࠕ߇ᔅⷐߣߔࠆ QoS ࠍឭଏߢ߈ࠆㅍାࡇࠕ߇ㆬ߫ࠇ㧘ߎࠇ߇ฃାࡇࠕߦࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ߤߩࠝࡉࠫࠚࠢ࠻න૏ࠍㅍାߔࠆ߆ࠍ␜ߔࠬࠤࠫࡘ࡯࡞ࠍ޽ࠄ߆ߓ߼᳿߼ߡ߅ߊ㕒⊛ PMSS(SPMSS)ࡕ
࠺࡞ࠍ⺰ߓ㧘ߘߩࠬࠤࠫࡘ࡯࡝ࡦࠣ࡮ࠕ࡞ࠧ࡝࠭ࡓࠍ⼏ ⺰ ߒ ߡ ޿ ࠆ ‫ ޕ‬ᣢ ߦ 㧘 [Itaya, Enokido, Takizawa,
ICPP2005] ߦࠃࠆ PMSS ࠕ࡞ࠧ࡝࠭ࡓ߇޽ࠆ߇㧘ߎࠝࡉࠫࠚࠢ࠻ࠍㅍାߔࠆ߽ߩߢ޽ࠆ‫⋥ޕ‬೉MSS(SMSS)ߪߐࠄߦ㧘એਅߩੑ⒳ࠍ⠨߃ࠆߎߣ߇ߢߎߢߪⶄᢙߩㅍାࡇࠕߩㅍାᤨ㑆ࠍᦨዊߣߔࠆߎߣ߇⋡ᮡߣߥߞߡ޿ߚ‫߼ߚߩߎޕ‬㧘ฃାࡇࠕߢ㧘ࠝࡉࠫ߈ࠆ㧦•㕒⊛ SMSS㧔SSMSS: static SMSS㧕ࡕ࠺࡞‫ޕ‬ࠚࠢ࠻න૏ࠍฃାߒߡ߆ࠄ೑↪⠪ߦ಴ജ㧘଀߃߫ࡆ࠺േ⊛ SMSS㧔DSMSS: dynamic SMSS㧕ࡕ࠺࡞‫ޕ‬ࠝ࠺࡯࠲ߩ⴫␜߹ߢߩಣℂᤨ㑆߇⠨ᘦߐࠇߡ߅ࠄߕ㧘ᔅⷐߥ QoS ߩࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ࠍฃାߪ໧㗴ߣߥߞߡ޿ߚ‫߼ߚߩߎޕ‬㧘ᧄ⺰ᢥߢߪ㧘ฃାࡇ•㕒⊛ SMSS㧔SSMSS㧕ߪࡕ࠺࡞ߢߪ㧘ฃାࡇࠕ߇㧘ฃାࡇࠕߢߩࡃ࠶ࡈࠔ࡝ࡦࠣᤨ㑆߇㐳ߊߥࠆߎߣ߇
ࠕ߇ᦨೋߩࠝࡉࠫࠚࠢ࠻න૏ࠍฃାߒߡ߆ࠄ QoS ࠍߢ߈ࠆࠃ߁ߦㅍାࠍⴕ߁ㅍାࡇࠕࠍ޽ࠄ߆ߓ߼᳿߼ḩ⿷ߒߥ߇ࠄㅪ⛯⊛ߦࠝࡉࠫࠚࠢ࠻ࠍ಴ജߔࠆߎߣߡ ߅ ߊ ߽ ߩ ߢ ޽ ࠆ ‫ ߦ ࠇ ߎ ޕ‬ኻ ߒ ߡ 㧘 േ ⊛SMSS(DSMSS)ࡕ࠺࡞ߢߪ㧘⃻࿷ㅍାਛߩㅍାࡇࠕ߇ߣ㧘ࠝࡉࠫࠚࠢ࠻න૏ࠍฃାࠝࡉࠫࠚࠢ࠻߇ฃାߒߡ

ࡇࠕߩਛ߆ࠄ QoS ᧦ઙࠍḩ⿷ߔࠆㅍାࡇࠕࠍㆬ߮㧘ࠃ߁ߦㅍାࠍⴕ߁ࠬࠤࠫࡘ࡯࡝ࡦࠣ࡮ࠕ࡞ࠧ࡝࠭ࡓࠍ

ᔅⷐߥ QoS ࠍㆡ↪ߢ߈ߥߊߥߞߡߊࠆߣ㧘ઁߩㅍା߆ࠄ಴ജߔࠆ߹ߢࡃ࠶ࡈࠔ࡝ࡦࠣᤨ㑆ࠍᦨዊߣߔࠆߎࠇߦㅍାࠍⴕࠊߖࠆ߽ߩߢ޽ࠆ‫ߪߢ┨ᧄޕ‬㧘DSMSS⠨᩺ߒߚ‫ߦࠄߐޕ‬㧘ㅍାࡇࠕߩ᡿㓚㧘ࡀ࠶࠻ࡢ࡯ࠢߩ
ユマ㧘ฃାࡇࠕߩࡃ࠶ࡈࠔࠝ࡯ࡃ࡯࡜ࡦߦࠃࠅ㧘ฃାࡕ࠺࡞ߦߟ޿ߡᬌ⸛ࠍⴕߞߡ޿ࠆ‫⃻ޕ‬࿷ߩㅍାࡇࠕߩ
QoS ߇ૐᷫߒߡ߈ߚߣ߈ߦ㧘޽ࠄ߆ߓ߼ᰴߩㅍାࡇࠕࠍ⊒⷗ߒ㧘ㅍାḰ஻ࠍⴕࠊߖࠆ‫⺰ᧄޕ‬ᢥߢߪ㧘ᣂᣥߩࡇࠕߢࠝࡉࠫࠚࠢ࠻න૏߇⚗ᄬ߹ߚߪㆃᑧฃାߔࠆߎߣ߇޽ࠆ‫ࠅࠃߦࠇߎޕ‬㧘ࠝࡉࠫࠚࠢ࠻න૏ࠍㅪ⛯⊛ߦ಴ജߢ߈ߥ޿໧㗴߇޽ࠆ‫߼ߚߩߎޕ‬㧘ㅪ⛯ߒߚ d ୘㧙㧙ߩࠝࡉࠫࠚࠢ࠻න૏ߦኻߒߡ৻ߟߩࡄ࡝࠹ࠖන૏ࠍ⸳ߌ㧘ߎࠇࠍㅍାࡇࠕߦಽᢔߔࠆߎߣߦࠃࠅ㧘d + 1㓚ߔࠆߚ߼ߦ㧘ㅪ⛯ߒߚࠝࡉࠫࠚࠢ࠻න૏ߣࡄ࡝࠹ࠖ୘ߩන૏ߩਛߩߤࠇ߆৻ߟ߇⚗ᄬߒߡ߽ోࠝࡉࠫࠚߘߩ⹏ଔࠍⴕߞߚ‫⎇ߩࠄࠇߎޕ‬ⓥᚑᨐߪ㧘P2P ࠝ࡯ࡃࠢ࠻න૏ࠍㅪ⛯ߒߡ಴ജߢ߈ࠆᣇᑼࠍ⠨᩺ߒߚ‫ߚ߹ޕ‬㧘࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢߢߩࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠨ࡯ࡆࠬࠍฦㅍାࡇࠕߣฃାࡇࠕ㑆ߩࡃ࡯ࠬ࠻⊛ࠝࡉࠫࠚࠢ࠻ឭଏߔࠆߚ߼ߩ޽ࠄߚߥᨒ⚵ߺߣߥࠆ߽ߩߢ޽ࠆ‫ޕ‬ᣢන૏ࠍ㧘ⶄᢙߩㅍାࡇࠕ߆ࠄㅍାߔࠆᣇᑼࠍ⠨᩺ߒ㧘න૏⚗ᄬߦኻߒߡ߽㧘ࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߦ㧘2 ઙߩ⺰ᢥ(╩㗡⪺⠪)ࠍ࿖㓙⺰ᢥ⹹ߦ⊒⴫ߒ㧘10ࠍㅪ⛯಴ജߢ߈ࠆ‫⹏ࠅࠃߦࡦ࡚ࠪ࡯࡟ࡘࡒࠪޕ‬ଔࠍⴕઙߩ⺰ᢥ(4 ઙߪ╩㗡⪺⠪)ࠍ࿖㓙ળ⼏ߢ⊒⴫ߒߡ޿ࠆ‫ޕ‬޿㧘ࡀ࠶࠻ࡢ࡯ࠢߩ⚗ᄬ₸ߦኻߒߡ㧘ฃାࡇࠕ߇ㅪ⛯߹ߚ㧘ߎࠇࠄߩ⎇ⓥᚑᨐߪ࿖㓙⊛ߦ߽㜞ߊ⹏ଔߐࠇ㧘ߒߡࠝࡉࠫࠚࠢ࠻න૏ࠍ಴ജߢ߈㧘߆ߟࡃ࠶ࡈࠔ࡝ࡦࠣᤨ㑆ࠍ⍴❗ߢ߈ࠆߎߣࠍ␜ߒߚ‫ޕ‬એ਄ߩ⎇ⓥᚑᨐߪ㧘⾨ࠍฃ⾨ߒߡ޿ࠆ‫ߦࠄߐޕ‬ਛፉᐔ๺⽷࿅߆ࠄ߽ 2008ਅ⸥ߩ⺰ᢥߣߒߡ⊒⴫ߐࠇߡ޿ࠆ‫ޕ‬

Goudariznemati, A., Enokido, T., and Takizawa,ᐕᐲߦ⎇ⓥഥᚑࠍฃ⾨ߒߡ޿ࠆ‫ޕ‬Streaming Multimedia Objects in P2P Overlayඳ჻㧔Ꮏቇ㧕ߩቇ૏⺰ᢥߣߒߡචಽߥଔ୯ࠍ᦭ߔࠆ߽

•M., “Scheduling Algorithms for ConcurrentlyNetworks,” International Journal of Computer࿖㓙ળ⼏ BWCCA2007 ߣ NBiS2008 ߣߢ best paperࠃߞߡ㧘ᧄ⺰ᢥߪ㧘Ꮏቇ⊛ߦᣂⷙᕈ㧘᦭↪ᕈ߇޽ࠅ㧘ߩߣ⹺߼ࠄࠇࠆ‫ޕ‬

Systems Science and Engineering, Vol. 25, No.
2, 2010, pp. 47-61.
•Goudarzinemati, A., Enokido, T., and Takizawa,M., “Models for P2P Multi-Source Streaming,”

Proc. of the 3rd International Conference
Complex, Intelligent and Software Intensive

Systems (CISIS2009), Fukuoka, Japan, March2009, pp. 35-42.
•

Goudarzinemati, A., Enokido, T., and Takizawa,M., “Serial and Parallel Transmission Modelsfor Multi-source Streaming of Multimedia

Objects, ” Proc. of IEEE the 22nd International
Conference

NetworkingonandAdvanced

Applications

Information(AINA2009),

Bradford, UK., May 2009, pp. 479-486.

ᧄ⺰ᢥߢߪ㧘㊀ⷐߥᖱႎࠪࠬ࠹ࡓߩࡕ࠺࡞ࠍߥߞߡ߈ߡ޿ࠆ P2P ࠝ࡯ࡃ࡟ࠗ࡮ࡀ࠶࠻ࡢ࡯ࠢ਄ߦಽᢔߒߚࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ߩࠬ࠻࡝࡯ࡒࡦࠣ࡮ࠨ࡯ࡆࠬࠍታ⃻ߔࠆߚ߼ߩᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ(MSS)ࡕ࠺࡞ࠍ⼏⺰ߒߡ޿ࠆ‫ߩߎޕ‬ਛߢ㧘߹ߕⶄᢙߩㅍାࡇࠕߩਛߢ৻ᤨߦ৻ߟߩㅍାࡇࠕ߇ㅍାࠍⴕ޿㧘QoS ૐਅߦኻߒߡ੐೨ߦઍᦧㅍାࡇࠕࠍ↪ᗧߔࠆേ ⊛ ⋥ ೉ ᄙ ㅍ ା ࡇ ࠕ ࡮ ࠬ ࠻ ࡝ ࡯ ࡒ ࡦ ࠣ (DSMSS:dynamic serial multi-source streaming)ࡕ࠺࡞ࠍᣂ

ߚߦឭ᩺ߒ㧘ߘߩ⹏ଔࠍⴕߞߚ‫ߦࠄߐޕ‬㧘ⶄᢙߩㅍାࡇࠕ߇ਗ೉ߦࡑ࡞࠴ࡔ࠺ࠖࠕ࡮ࠝࡉࠫࠚࠢ࠻ࠍㅍାߔࠆਗ೉ᄙㅍାࡇࠕ࡮ࠬ࠻࡝࡯ࡒࡦࠣ(PMSS: parallelmulti-source streaming)ࡕ࠺࡞ࠍᬌ⸛ߒߚ‫ߩߎޕ‬ਛߢ㧘ᣂߚߦฃାࡇࠕߢߩࠝࡉࠫࠚࠢ࠻න૏ߩ಴ജᤨ㑆ߣ㧘ࠝࡉࠫࠚࠢ࠻න૏ߩ⚗ᄬ㧘ㆃᑧߦኻߔࠆ⠴᡿㓚ᕈࠍ଻㧙㧙ඳ჻ቇ૏⺰ᢥክᩏⷐᣦᚑ く ᄢ ቇቇ૏ⷙೣ㧔ᤘ๺  ᐕ㧠᦬㧝ᣣᢥㇱ⋭઎╙㧥ภ㧕╙㧤᧦ߩⷙቯߦࠃࠆ౏⴫ࠍ⋡⊛ߣߒߡ㧘ᧄቇߦ߅޿ߡඳ჻ߩቇ૏ࠍ᝼ਈߒߚ⠪ߩ⺰ᢥክᩏߩⷐᣦࠍᰴߩߣ߅ࠅ⊓タߔࠆ‫ޕ‬ቇ૏⸥⇟ภߦઃߒߚ↲ߪᧄቇቇ૏ⷙೣ╙㧟᧦╙㧟㗄ߦࠃࠆ߽ߩߢ޽ࠆ‫ޕ‬᳁     ฬᄤ㆐ ᵗᢥ

ቇ૏ߩ⒳㘃ඳ჻㧔Ꮏቇ㧕ቇ૏⸥⇟ภ↲╙  ภቇ૏᝼ਈᐕ᦬ᣣ

 ᐕ㧟᦬  ᣣቇ૏᝼ਈߩⷐઙ

ቇ૏ⷙೣ╙㧠᧦╙㧝㗄⹥ᒰ⠪ቇ ૏ ⺰ ᢥ 㗴 ⋡Measurement of Productive Efficiency of Decision Making Units⺰ ᢥ ክ ᩏ ᆔ ຬਥᩏ ਄↰  ᔀᆔຬ ጤፒ  ቇ࡮ᷰㆺ ৻ⴡߩ⢛᥊㧘⋡⊛ߥߤߦߟ޿ߡㅀߴ㧘⺰ᢥߩో૕᭴ᚑߦߟ㨇⺰ᢥౝኈߩⷐᣦ㨉޿ߡ߽ㅀߴߡ޿ࠆ‫ޕ‬ ᧄቇ૏⺰ᢥߪ㧘ᗧᕁ᳿ቯ⚵❱ (Decision Making Unit㧘એਅ㧘DMU ߣ⇛ߔ) ߩ⋧ኻ⊛ല₸ߩ᷹ቯᣇᴺߣ㧘DMUߩ⚻ᷣ⊛߹ߚߪ⚻༡⊛ಽᨆᣇᴺߣ㧘ല₸ߩᡷༀ⸘↹ࠍ╷ቯߔࠆᣇᴺࠍኻ⽎ߣߒߡ޿ࠆ㧔એਅ㧘ߎࠇࠄࠍ✚⒓ߒߡല₸᷹ቯߣ⸒߁㧕‫ߚ߹ޕ‬㧘ડᬺᬺ❣߹ߚߪല₸ߩ╙㧞┨ߪ̌Network DEA for matrix-type organizations

and super-efficiency̍㧘‫߼ߚߩ❱⚵ဳࠬࠢ࠶࡝࠻ࡑޟ‬ߩࡀ࠶࠻ࡢ࡯ࠢ DEA ߣ⿥ല₸ᕈ‫ޕࠆ޽ߢޠ‬ല₸᷹ቯߩ ଢ ೑ ߥ ࠷ ࡯ ࡞ ߣ ߒ ߡ 㧘 DEA (Data Envelopment✚ว⹏ଔᜰᢙߣ⸒ࠊࠇࠆᩣଔࠍ㐳ᦼ㑆ߦࠊߚߞߡ੍Analysis)߇޽ࠆ‫ޕ‬ㅢᏱߩ DEA ߪ⚵❱ߩౝㇱ᭴ㅧࠍ⠨᷹ߢ߈ࠆࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒߡ޿ࠆ‫ޕ‬ᘦߒߥ޿ߢ㧘ᄖㇱ౉಴ജߩߺߢല₸᷹ቯࠍⴕߞߡ޿ࠆ‫ޕ‬ߒ߆ߒ㧘⚵❱ߦߪౝㇱ᭴ㅧ߇޽ࠅ㧘ߘߩ㑆ߩౝㇱ౉಴ᧄቇ૏⺰ᢥߪ㧤┨߆ࠄ᭴ᚑߐࠇߡ߅ࠅ㧘╙㧝┨ߪജ߇޽ࠆ‫ޕ‬ᄖㇱ౉಴ജߣౝㇱ౉಴ജߩਔᣇࠍ↪޿ߡല

̌Introduction̍㧘╙㧞┨ߪ̌Network DEA for matrix-type₸᷹ቯࠍⴕ߁㧘ࡀ࠶࠻ࡢ࡯ࠢ DEA ߇޽ࠆ‫ઁޕ‬ᣇ㧘⦡‫ޘ‬organizations and super-efficiency̍㧘╙㧟┨ߪ̌Networkߥ࿾ၞන૏ߢ✬➏ߐࠇߡ޿ࠆ↥ᬺㅪ㑐⴫ߪ․ቯߩ࿾

DEA and input-output tables̍㧘╙㧠┨ߪ̌Network DEAၞߣᦼ㑆ߦⴕࠊࠇߚ⽷ߣࠨ࡯ࡆࠬߩ↥ᬺ㑆ขᒁࠍ৻in DEA assurance region method̍㧘╙㧢┨ߪ̌Minimum࡯࠲ߩቲᐶߢ޽ࠆߎߣ߽⠨߃ࠆߣ㧘ߘࠇࠍ᦭ല೑↪ߢand returns to scale̍㧘╙㧡┨ߪ̌Determination of Bounds
distancealgorithms

andefficienciesofߟߩⴕ೉㧔ࡑ࠻࡝࠶ࠢࠬ㧕ߦ␜ߒߚ⛔⸘⴫ߢ޽ࠅ㧘࠺

chemical߈ࠆᣇᴺ߇⠨߃ߛߐࠇߥ޿㒢ࠅቲߩᜬߜ⣣ࠇߢ޽ࠆ‫ޕ‬

models and fractal analysis̍㧘╙㧤┨ߪ̌Conclusion̍㐷ߣᦨ⚳ㇱ㐷ࠍ߽ߟࡀ࠶࠻ࡢ࡯ࠢߛߌࠍᛒߞߡ߈ߚ

ߣߥߞߡ޿ࠆ‫ޕ‬ߚ߼㧘↥ᬺㅪ㑐⴫ߩಽᨆߦߪ૶߃ߥ޿‫ߢߎߘޕ‬㧘ᧄ⎇ ╙㧝┨ߪ̌Introduction̍㧘‫ࠅ޽ߢޠ⸒✜ޟ‬㧘ᧄ⎇ⓥⓥߢߪ㧘DEA ߣ↥ᬺㅪ㑐⴫ࠍ↪޿ߡ㧘࿖᳃⚻ᷣ߿࿾

companies̍㧘╙㧣┨ߪ̌Forecasting stock prices using ARߎࠇ߹ߢឭ᩺ߐࠇߡ߈ߚࡀ࠶࠻ࡢ࡯ࠢ DEA ߪ㐿ᆎㇱ㧙㧙╙ 㧢 ┨ ߪ ̌ Minimum distance algorithms andၞ⚻ᷣߩല₸᷹ቯࠍߔࠆߎߣߩߢ߈ࠆᣂߒ޿ࡑ࠻࡝
࠶ࠢࠬဳࡀ࠶࠻ࡢ࡯ࠢ DEA ߩࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒ

efficiencies of chemical companies̍㧘‫〒ޟ‬㔌ᦨዊൻࠕߡ޿ࠆ‫ޕ‬DEA ߪ౉಴ജߩᢙ߇Ⴧ߃ࠆߣല₸⊛㧔ല₸࡞ࠧ࡝࠭ࡓߣൻቇળ␠ߩല₸ᕈ‫ޕࠆ޽ߢޠ‬ല₸ߩᡷༀ୯㧝㧕ߣ್ቯߐࠇࠆ DMU ߽Ⴧ߃ߡ޿ߊߚ߼㧘౉಴ജ⸘↹ࠍ૞ࠆߚ߼ߦ㧘ෳ⠨ߣߔࠆ DMU ࠍㆬᛯߔࠆ㓙㧘ᢙ߇ᄢ߈޿↥ᬺㅪ㑐⴫ಽᨆߢߪ㧘ല₸⊛ߥ DMU 㑆ߩఝഠࠍ᷹ࠆዤᐲ߇ᔅⷐߣߥࠆ‫ဳࠬࠢ࠶࡝࠻ࡑߢߎߘޕ‬ࡀ࠶࠻ࡢ࡯ࠢ DEA ߦ߅ߌࠆ㧝ࠃࠅ߽ᄢ߈ߥല₸୯㧔⿥ല₸୯㧕߽᷹ࠇࠆዤᐲࠍឭ᩺ߒߡ޿ࠆ‫ޕ‬ᓥ᧪ߪ㧘ࠕ࡞ࠧ࡝࠭ࡓߩ◲ᤃߐࠍ㊀ࠎߓߡ⹏ଔኻ⽎
DMU ߆ࠄߺߡᦨ߽㆙޿૏⟎ߦ޽ࠆ DMU ࠍㆬᛯߒߡ޿ࠆߚ߼ߦ㧘ෳ⠨ߦߔࠆߎߣ߇࿎㔍ߥ଀߇ᄙ߆ߞߚ‫ޕ‬ᧄ⺰ᢥߢߪ㧘⹏ଔኻ⽎ DMU ߆ࠄߩ〒㔌߇ᦨዊߢ޽ࠆ

DMU ࠍෳ⠨ߣߔࠆ Add-min ࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒ㧘 ╙㧟┨ߪ̌Network DEA and input-output tables̍㧘ൻቇળ␠ߦㆡ↪ߒߡߘߩ᦭ലᕈࠍ⏕⹺ߒߡ޿ࠆ‫ޕ‬ᣣᧄߩ㧠㧣ㇺ㆏ᐭ⋵㑆ߩ↥ᬺㅪ㑐⴫ߦ╙㧞┨ߢㅀߴ ╙㧣┨ߪ̌Forecasting stock prices using AR models‫ ࠢ࡯ࡢ࠻࠶ࡀޟ‬DEA ߣ↥ᬺㅪ㑐⴫‫ߕ߹ޕࠆ޽ߢޠ‬㧘ࠄࠇߚࡑ࠻࡝࠶ࠢࠬဳࡀ࠶࠻ࡢ࡯ࠢ DEA ࠍㆡ↪ߒߡand fractal analysis̍㧘‫ޟ‬AR㧔⥄Ꮖ࿁Ꮻ㧕ࡕ࠺࡞ߣࡈㇺ㆏ᐭ⋵ߩല₸ᕈ߿↥ᬺߩ․ᓽ㧘ෳ⠨ߣߔߴ߈ㇺ㆏ᐭ࡜ࠢ࠲࡞ࠍ૶ߞߚᩣଔ੍᷹‫ ޕࠆ޽ߢޠ‬ᩣଔߪડᬺߩ⋵ߪߤߎ߆ߥߤࠍ᣿ࠄ߆ߦߒߡ޿ࠆ‫ߦࠄߐޕ‬㧘ࠕࠫ✚ว⹏ଔᜰᮡߣ⋡ߐࠇ㧘ߘߩ੍᷹ߪ㊀ⷐߥ⺖㗴ߢ޽ࠆ‫ޕ‬ࠕ࡮ᄥᐔᵗߩ⻉࿖㑆↥ᬺㅪ㑐⴫ߦ߽ࡑ࠻࡝࠶ࠢࠬဳࡀ

DEA ߣ⇣ߥࠅ㧘ᩣଔߢߪ㧘DMU ߩ⚻༡⊛ಽᨆ߿ല₸࠶࠻ࡢ࡯ࠢ DEA ࠍㆡ↪ߒߡㇺ㆏ᐭ⋵ߣห᭽ߩಽᨆࠍߩᡷༀ⸘↹ߩ╷ቯߪߢ߈ߥ޿߇㧘ᩣଔߩ੍᷹ࠍㅢߓߡⴕߞߡ޿ࠆ‫ޕ‬዁᧪ߩല₸ࠍ੍᷹ߢ߈ࠆน⢻ᕈ߇޽ࠆ‫⺰ᧄޕ‬ᢥߢߪ㧘AR ࡕ࠺࡞ߣࡈ࡜ࠢ࠲࡞ಽᨆࠍ⚵ߺวࠊߖࠆߎߣߦࠃ╙㧠┨ߪ̌Network DEA and returns to scale̍㧘‫ࡀޟ‬࠶࠻ࡢ࡯ࠢ DEA ߣⷙᮨߩല₸ᕈ‫ⷙޕࠆ޽ߢޠ‬ᮨߦ㑐ࠅ㧘ᩣଔࠍ㐳ᦼ㑆ߦࠊߚߞߡ੍᷹ߢ߈ࠆࠕ࡞ࠧ࡝࠭ࡓ
ࠍឭ᩺ߒߡ޿ࠆ‫ޕ‬㧞,㧞㧤㧟␠ ߩ⚂㧟㧜ᐕߦࠊߚࠆᩣ

ߔࠆ෼ⓠ㧔ⷙᮨߩല₸ᕈ㧘Returns to Scale㧘એਅߢߪଔ࠺࡯࠲ࠍ૶ߞߡ㧘ᩣଔ߇ࡈ࡜ࠢ࠲࡞ᕈࠍᜬߟߎߣࠍ

RTS ߣ⇛ߔ㧕ߪࡒࠢࡠ⚻ᷣቇߩ᭎ᔨߩ৻ߟߢ㧘౉ജߩ᣿ࠄ߆ߦߒ㧘㧝㧜㧜ᣣ㧔ታⒿ௛ᣣߢ⚂ඨᐕ㧕ᓟߩ੍᷹ᄌൻߦኻߔࠆ಴ജߩᄌൻࠍ⴫ߔᜰᮡߢ޽ࠅ㧘ㅢᏱᄙ౉߇ᐔဋ㧞ഀ⒟ᐲߩ⺋Ꮕߢน⢻ߦߥࠆߎߣࠍ␜ߒߡ޿ജ㧝಴ജࠍᛒ߁‫ޕ‬ㅢᏱߩ DEA ߢߪᄙ౉ജᄙ಴ജߩࠆ‫ޕ‬

RTS ࠍ᷹ቯߢ߈ࠆ‫⎇ᧄޕ‬ⓥߢߪ㧘ㅢᏱߩ DEA ߩ RTSࠍࡀ࠶࠻ࡢ࡯ࠢ DEA ߦ᜛ᒛߒ㧘㧠㧣ㇺ㆏ᐭ⋵㑆ߩ↥╙㧤┨ߪ̌Conclusion̍㧘‫⎇ᧄޕࠆ޽ߢޠ⺰⚿ޟ‬ⓥᬺㅪ㑐⴫ߦㆡ↪ߒߡ㆏Ꮊ೙ߩዉ౉ߩലᨐࠍᬌ⸛ߒߡߦࠃࠅ㧘DEA ࠍ↥ᬺㅪ㑐⴫ߦㆡ↪ߔࠆࠕ࡞ࠧ࡝࠭ࡓ޿ࠆ‫⚿ߩߘޕ‬ᨐ㧘⃻࿷ߩㇺ㆏ᐭ⋵ߪ⃻ઍߩ↥ᬺ␠ળߢߣᚻᴺࠍឭ᩺ߒߚߎߣ㧘DEA ࠍ↥ᬺㅪ㑐⴫ߦㆡ↪ߔߪᄢ߈ߔ߉ࠆ႐ว߇޽ࠅ㧘ឭ᩺ߐࠇߡ޿ࠆ㆏Ꮊߪ㧘ᄢࠆߎߣߢ㧘ᄙߊߩᣂߒ޿ࡑࠢࡠ⚻ᷣቇ߅ࠃ߮ࡒࠢࡠ⚻ㇱಽ߇ⷙᮨߩ෼ⓠߩૐᷫߩߚ߼ߦ↥ᬺല₸߇ૐਅߔᷣቇߩಽᨆ߇಴᧪ࠆߎߣࠍ␜ߒߚߎߣ㧘㗔ၞ㒢ቯᴺߩࠆน⢻ᕈ߇㜞޿ߥߤߩ⍮⷗ࠍᓧߡ޿ࠆ‫ޕ‬㗔ၞࠍ᳿߼ࠆࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒߚߎߣ㧘ᦨ⍴〒㔌╙㧡┨ߪ̌Determination of Bounds in DEA assurance

region method̍㧘‫ޟ‬DEA 㗔ၞ㒢ቯᴺߦ߅ߌࠆ㗔ၞ᳿ቯߦ޽ࠆෳᾖ DMU ࠍല₸⊛ߦត⚝ߔࠆࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒߚߎߣ㧘੐଀⎇ⓥߢ᦭↪ᕈࠍ␜ߒߚߎߣ㧘㐳ᦼᩣଔ੍᷹ߩน⢻ߥࠕ࡞ࠧ࡝࠭ࡓࠍឭ᩺ߒߚߎߣߥߤ㧘ᴺ‫ ޕࠆ޽ߢޠ‬DEA ߪ⹏ଔኻ⽎ߦߣߞߡᦨ߽᦭೑ߣߥᗧᕁ᳿ቯਥ૕ߩല₸ᕈ᷹ቯߦ㑐ࠊࠆ᭽‫⺖ߥޘ‬㗴ࠍ⸃ࠆਸ਼ᢙ㧔౉಴ജߩ㊀ⷐᐲ㧕ࠍㆬ߱ߚ߼㊀ⷐᐲ߇࠯ࡠ㧘᳿ߒ㧘᦭ല೑↪ߩᣇᴺ߇ಽ߆ࠄߥ߆ߞߚ↥ᬺㅪ㑐⴫ߩߔߥࠊߜήⷞߐࠇࠆ౉಴ജ߇಴߿ߔ޿ߣ޿߁ᰳὐ߇ᣂߒ޿ಽᨆᴺࠍឭ᩺ߒߚߎߣߢ⤘ᄢߥ࠺࡯࠲ߩಽᨆ޽ࠆ‫ߢߎߘޕ‬ਸ਼ᢙߩ㗔ၞࠍ㒢ቯߔࠆ DEA 㗔ၞ㒢ቯᴺ߇ᦼᓙߢ߈ࠆߥߤ㧘ߘߩᎿቇ⊛ᗧ⟵ߪᭂ߼ߡᄢ߈޿߽߇ឭ᩺ߐࠇߚ߇㧘㗔ၞߩ᳿ቯᣇᴺߪ᣿ࠄ߆ߢߥ߆ߞߚ‫ޕ‬ߩߢ޽ࠆ‫ޕ‬ᧄ⎇ⓥߢߪ㧘ᓥ᧪޽ࠆ㗔ၞ㒢ቯᴺࠕ࡞ࠧ࡝࠭ࡓࠍ೑↪
ߔࠆ㓙ߦᔅⷐߥ㗔ၞߩ਄ਅ㒢ࠍ᳞߼ࠆࠕ࡞ࠧ࡝࠭ࡓ ࠃߞߡ㧘ᧄ⺰ᢥߪඳ჻㧔Ꮏቇ㧕ߩቇ૏⺰ᢥߦ୯ߔࠆࠍឭ᩺ߒ㧘㊁⃿ㆬᚻ㧘ൻቇળ␠ߦㆡ↪ߒߡߘߩ᦭ലᕈ߽ߩߢ޽ࠆ‫ ޕ‬ࠍ⏕⹺ߒߡ޿ࠆ‫ޕ‬㧙㧙ඳ჻ቇ૏⺰ᢥክᩏⷐᣦᚑ く ᄢ ቇቇ૏ⷙೣ㧔ᤘ๺  ᐕ㧠᦬㧝ᣣᢥㇱ⋭઎╙㧥ภ㧕╙㧤᧦ߩⷙቯߦࠃࠆ౏⴫ࠍ⋡⊛ߣߒߡ㧘ᧄቇߦ߅޿ߡඳ჻ߩቇ૏ࠍ᝼ਈߒߚ⠪ߩ⺰ᢥክᩏߩⷐᣦࠍᰴߩߣ߅ࠅ⊓タߔࠆ‫ޕ‬ቇ૏⸥⇟ภߦઃߒߚਸߪᧄቇቇ૏ⷙೣ╙㧟᧦╙㧠㗄ߦࠃࠆ߽ߩߢ޽ࠆ‫ޕ‬᳁     ฬ₺ ാቇ૏ߩ⒳㘃ඳ჻㧔Ꮏቇ㧕ቇ૏⸥⇟ภਸ╙  ภቇ૏᝼ਈᐕ᦬ᣣ

 ᐕ㧟᦬  ᣣቇ૏᝼ਈߩⷐઙቇ૏ⷙೣ╙㧠᧦╙㧞㗄⹥ᒰ⠪ቇ ૏ ⺰ ᢥ 㗴 ⋡ੇ῎࿾ߢߩᬀ‛↢⢒㧘㘩ᢱ↢↥ߩߚ߼ߩⶄวᯏ⢻ᕈ‛⾰ߩ㐿⊒ߣ೑↪

⺰ ᢥ ክ ᩏ ᆔ ຬਥᩏ ዊፉ ♿ᓼᆔຬ ㉿Ꮉ ㊀ᄦ࡮ጊፒ ┨ᒄ   ട⮮  ⨃㧔․೎⎇ⓥ᜗⡜ᢎ᝼㧕ㇱߪᯏ⢻ᕈ‛⾰วᚑߣ⹏ଔ㧘╙㧟ㇱߪⶄวᯏ⢻ᕈ‛⾰㧔଻㨇⺰ᢥౝኈߩⷐᣦ㨉᳓೷࡮✭ലᕈ⢈ᢱⶄว᧚ᢱ㧕ߩ⵾ㅧߣᔕ↪㧘╙㧠ㇱߪ⚿ᧄ⺰ᢥߪੇ῎࿾ߢߩᬀ‛↢⢒㧘㘩ᢱ↢↥ߩߚ߼ߩ⦟ᅢ⸒ߣߥߞߡ޿ࠆ‫ޕ‬╙ 1 ㇱ‫ޡ‬ᐨ⺰‫ ╙ߪޢ‬1 ┨‫ ╙ޕࠆߥࠅࠃޢ⸒✜ޡ‬1 ┨ߢߥ଻᳓ᕈߣ✭ലᕈ⢈ᢱߩᯏ⢻ࠍᜬߟⶄวᯏ⢻ᕈ‛⾰ࠍ㐿⊒ߒ㧘ੇ῎࿾࿯ფߩ଻᳓ᕈߣ࿯ფߩ㙃ಽਇ⿷ߩ໧㗴ࠍหߪ㧘਎⇇․ߦਛ࿖ߩᴕṼൻߩ⃻⁁ߣᓇ㗀ߦߟ޿ߡߩ᭎⺰ᤨߦ⸃᳿ߔࠆߎߣࠍ⋡ᜰߒߚ߽ߩߢ޽ࠆ‫ߩߎޕ‬᭽ߥ⎇ⓥ

ࠍ⸥ߒ㧘ᧄ⎇ⓥߢኻ⽎ߣߔࠆੇ῎࿾ߢߩᬀ‛↢⢒㧘㘩ᢱߩ⋡⊛ࠍ㆐ᚑߔࠆߚ߼ߦ㧘߹ߕනᯏ⢻ࠍ᦭ߔࠆᯏ⢻ᕈ‛↢↥ߩߚ߼ߩᯏ⢻ᕈ‛⾰㐿⊒ߩ⃻⁁ߣᛛⴚࠍឭ␜ߒ㧘⎇⾰ߣߒߡ଻᳓ᕈะ਄ߩߚ߼ߩ⠴Ⴎᕈࠪ࡝ࠞࠥ࡞࡯CMCⓥߩ⋡⊛ࠍㅀߴߡ޿ࠆ‫ޕ‬♽଻᳓೷㧘↢ಽ⸃ᕈ⏕଻ߩߚ߼ߩᩑᷦ♽଻᳓೷㧘ㆃലᕈ╙㧞ㇱ‫ޡ‬ᯏ⢻ᕈ‛⾰วᚑߣ⹏ଔ‫ߪޢ‬એਅߩ㧟ߟߩ┨ߢ⢈ᢱߣߒߡߩᣂဳ࠙࡟ࠕࡎ࡞ࡓ⓸⚛ࠍวᚑߒߚ‫৻ޕ‬ᣇ㧘᭴ᚑߐࠇߡ߅ࠅ㧘ߘࠇߙࠇ⋡⊛ߣ↪ㅜ߇⇣ߥࠆᯏ⢻ᕈ‛ⶄวᯏ⢻ᕈ‛⾰ߣߒߡ଻᳓೷࡮✭ലᕈ⢈ᢱࠍหᤨߦᜂᜬ

⾰ߢ޽ࠆ଻᳓೷޽ࠆ޿ߪ㜞ಽሶ⢈ᢱࠍวᚑߒ㧘วᚑߒߚߔࠆߚ߼ߦᦨ߽ㆡߒߚ‛⾰ߣߒߡࡐ࡝࠙࡟࠲ࡦࡈࠜ࡯ࡓᯏ⢻ᕈ‛⾰ߩᕈ⾰⹏ଔࠍⴕߞߡ޿ࠆ‫ޕ‬ࠍㆬᛯߒ㧘ߘߩ⵾ㅧᴺ߆ࠄᬌ⸛ߔࠆߎߣߦࠃࠅᏒ⽼ߩ଻╙㧞┨‫ޡ‬⠴Ⴎᕈࠪ࡝ࠞࠥ࡞࡯CMC ♽଻᳓೷ߩวᚑߣ᳓೷ߣㆃലᕈ⢈ᢱࠍ଻ᜬߒߚⶄวᯏ⢻ᕈ᧚ᢱߩวᚑ߇น⹏ଔ‫ߪߢޢ‬㧘଻᳓೷ߩๆ᳓ㅦᐲߣ⠴Ⴎᕈࠍᡷༀߔࠆߚ߼⢻ߢ޽ࠆߎߣࠍታ⸽ߒߚ‫῎ੇޕ‬࿾ㄘᬺ߳ߩᔕ↪ࠍ࿑ࠆ⋡ߦ㧘㜞ⷫ᳓ᕈ߿⠴Ⴎᕈࠍᜬߟࠪ࡝ࠞࠥ࡞ߣ CMC ♽଻᳓⊛ߢ㧘ᧄⶄวᯏ⢻ᕈ‛⾰ࠍ↪޿ߡᡷ⦟ߒߚੇ῎࿾ߢߩ࿯೷ߣߩⶄวൻࠍⴕ޿㧘⠴Ⴎᕈࠪ࡝ࠞࠥ࡞࡯CMC ♽଻᳓ფᡷ⦟ലᨐࠍಽᨆߒ㧘⍾⾰࿯ფᡷ⦟ലᨐ⊒⃻ߩࡔࠞ࠾࠭

CMC ♽଻᳓೷ߩ 64.5 g/g ߦኻߒ 103.4 g/g ߹ߢჇടߒߚ‫ޕ‬ࡓࠍ⸃᣿ߒߚ‫ᦨޕ‬ᓟߦᬀ‛↢⢒㧘↢↥ߦᔅⷐߥ᭽‫ߥޘ‬ᬌ⸛ࠍⴕߞߚ‫ޕ‬ᧄ⺰ᢥߪ㧠ㇱ᭴ᚑߦߥߞߡ߅ࠅ㧘╙㧝ㇱߪᐨ⺰㧘╙㧞೷ࠍᓧߡ޿ࠆ‫ޕ‬0.9 %ߩ NaCl ᳓ṁᶧਛߢߩๆ᳓₸ߪ㧘㘻๺ๆ᳓₸߹ߢߦ⥋ࠆᤨ㑆ߪ 2 ᤨ㑆߆ࠄ 1.5 ᤨ㑆߹ߢᷫዋߒ㧘ๆ᳓ㅦᐲ߇ᡷༀߐࠇߚ‫ޕ‬ๆ᳓㧔Ⴎ᳓㧕ࡔࠞ࠾࠭ࡓ㧙㧙ߦኻߔࠆ઒⺑ࠍឭ᩺ߒ㧘⹜㛎⚿ᨐߦၮߠ߈઒⺑ߩᅷᒰᕈሶ㗼ᓸ㏜ߣశቇ㗼ᓸ㏜ߣࠍ↪޿ߡ࿯ფ᭴ㅧߣ࿅☸ൻߒߚࠍ␜ߒߚ‫ޕ‬࿯ფ߇‛ℂ⊛ᕈ⾰ߦਈ߃ࠆᓇ㗀ࠍᛠីߒ㧘⍾⾰࿯ფߩ‛╙㧟┨‫↢ޡ‬ಽ⸃ᕈᩑᷦ♽଻᳓೷ߩวᚑߣ⹏ଔ‫ߪߢޢ‬㧘ⅣႺߦఝߒ޿଻᳓೷ࠍวᚑߔࠆߚ߼ߦ㧘ㅒ Ộࡑࠗࠢࡠℂᕈ߳ߩᓇ㗀ࠍ᣿ࠄ߆ߦߔࠆߣߣ߽ߦ⍾⾰࿯ფᡷ⦟ߩࡔࠞ࠾࠭ࡓࠍឭ᩺ߒߚ‫ޕ‬ࠛࡑ࡞࡚ࠪࡦ㊀วᴺࠍ↪޿ߡࠕࠢ࡝࡞㉄ߣᩑᷦࠍේᢱߣߒߡ࠽ࡁ↢ಽ⸃ᕈᩑᷦ♽଻᳓೷ࠍวᚑߒ㧘ๆ᳓₸ 800 ୚╙㧣┨‫ⶄޡ‬วᯏ⢻ᕈ‛⾰ߩੇ῎࿾ߢߩᬀ‛↢⢒㧘↢↥߳ߩലᨐ‫ޢ‬ߢߪ㧘ⶄวᯏ⢻ᕈ‛⾰ߩੇ῎࿾ߢߩᬀ‛↢⢒㧘ࠍ␜ߔ଻᳓೷ࠍᓧߡ޿ࠆ‫ޕ‬᳓ࠍๆ෼ߐߖߚ଻᳓೷ߪ㧘ߐ↢↥߳ߩലᨐࠍ⹏ଔߔࠆߚ߼㧘ⶄวᯏ⢻ᕈ‛⾰ࠍ⍾⾰࿯ࠄߦᄙ㊂ߩ᳓ਛߢ⦟ߊಽᢔߒ㧘࠽ࡁ☸ሶࠍᒻᚑߒߚ‫࠽ޕ‬

ფߦ 0.5 %ᷙวߒ㧘৻ቯߩ᳓᧦ઙਅߢ㧔1㧕ᣣᧄዊ᧻⩿(2)ࡁ↢ಽ⸃ᕈᩑᷦ♽଻᳓೷ᒻᚑߩࡔࠞ࠾࠭ࡓߦ㑐ߔࠆ઒⺑ਛ࿖ࡓ࡜ࠨࠠ࠙ࡑࠧࡗࠪߦኻߒߡએਅߩ⹜㛎ࠍታᣉߒߚ‫ޕ‬ࠍឭ᩺ߔࠆߣߣ߽ߦ㧘ߘߩᅷᒰᕈࠍㅘㆊ㔚ሶ㗼ᓸ㏜ࠍ↪

ߔߥࠊߜ಴⧘₸㧘ᩮ♽ߩᒻᘒ㧘⨲ਂ㧘↢⢒ᦼ㑆㧘෼㊂ߦ޿ߡᬌ⸽ߒߚ‫଻ߪߡ޿ߟߦ⾰‛ᧄޕ‬᳓೷એᄖߩ᭽‫↪ߥޘ‬ਈ߃ࠆᓇ㗀ࠍ⺞ߴ㧘ⶄวᯏ⢻ᕈ‛⾰ߩ᦭ߔࠆ଻᳓ᕈߣ⢈ㅜ߇น⢻ߢ޽ࠆߎߣ߽␜ໂߐࠇߚ‫ޕ‬ᢱ✭ലᕈ߇ᬀ‛↢⢒㧘↢↥ߦਈ߃ࠆലᨐࠍಽᨆߒߚ‫ޕ‬ᬀ‛ߩᚑ㐳ߩߚ߼ߦᔅⷐߥ᳓ߣ⢈ᢱ߇หᤨߦଏ⛎ߐࠇ╙㧠┨‫ޡ‬ᣂဳ࠙࡟ࠕࡎ࡞ࡓ⓸⚛ߩวᚑߣ⹏ଔ‫ߪߢޢ‬㧘୯㧕߇߶߷ 100㧑ߣߥࠆ࠙࡟ࠕࡎ࡞ࡓ⓸⚛ࠍวᚑߒߚ‫ޕ‬㜞ಽሶ⢈ᢱߩ㜞ല₸೑↪ߩߚ߼ߦ⓸⚛ߩ೑↪ല₸㧔AIߚߎߣߢ㧘㜞޿⋧੕૞↪㧘ߔߥࠊߜ㧘㜞޿᳓ߣ⢈ᢱߩ೑ዩ⚛ࠍࡎ࡞ࡑ࡝ࡦߦኻߒ 2 ࿁ߦಽߌߡࡕ࡞Ყߢ 3 ୚㊂ട↪₸߇⹺߼ࠄࠇ㧘ᄢ᏷ߦᬀ‛↢↥㊂߇Ⴧടߒߚ‫ޕ‬ዊ᧻⩿߃ߥ߇ࠄ㧘ࡅ࠼ࡠࠠࠪࡔ࠴࡟ࡦൻ෻ᔕࠍ pH8.0㧘᷷ᐲ 50

㨪60 ͠㧘120 ಽ㑆ⴕߞߚᓟ㧘ࡔ࠴࡟ࡦൻ෻ᔕࠍ pH5.0㧘ᧄ‛⾰ࠍ↪޿ࠆߣᦨ㜞 98㧑ߣߥࠅ㧘ᬀ‛↢↥㊂ߪ 9.8 ୚᷷ᐲ 90 ͠㧘90 ಽߩ᧦ઙߢⴕߞߚߣ߈㧘ᦨ߽㜞޿෼₸ࠍߦ㧘৻ᣇ૶↪᳓㊂ߪ 94㨪81㧑߹ߢᷫዋߒߚ‫৻ޕ‬ᣇࡓ࡜ࠨࠠ࠙ࡑࠧࡗࠪߦߟ޿ߡߪ㧘Ყセߣߒߡ㤛⍾ࠍ↪޿ߚߣ߈ߩ⊒⧘₸ߪ㧘㠽ข⍾ߛߌߩ႐วߩ⊒⧘₸ 65㧑ߦᲧߒߡ㧘ᓧߚ‫⦟ߦࠄߐޕ‬ᅢߥᓢ᡼ᕈലᨐ߽⏕⹺ߐࠇ㧘㜞޿ታ↪ᕈߩ⊒⧘₸ 24㧑ߦኻߒ 96㧑㧘ᬀ‛↢↥㊂ߢߪᦨᄢ 9.5 ୚߇ᦼᓙߐࠇߚ‫ޕ‬ߣߥߞߚ‫ޕ‬ᯏ⢻ᕈ‛⾰ߪ⍾࿯ფߩᡷ⦟᧚ߣߒߡ૶↪ߐࠇ╙㧟ㇱ‫ⶄޡ‬วᯏ⢻ᕈ‛⾰㧔଻᳓೷࡮✭ലᕈ⢈ᢱⶄว᧚ࠆઁ㧘ੇ῎࿾એᄖߩㄘᬺ㧘ᨋᬺߩᩕ㙃Ⴎଏ⛎೷ߣߒߡ↪

ᢱ㧕ߩ⵾ㅧߣᔕ↪‫ޢ‬ߪએਅߩ㧟ߟߩ┨ߢ᭴ᚑߐࠇߡ߅ࠅ㧘޿ߚ႐วߢ߽⢈ᢱߩᓢ᡼ᕈᯏ⢻ߪ⢈ᢱߩ㜞ല₸೑↪ࠍ߽╙㧞ㇱߢㅀߴߚන৻ᯏ⢻ߦ⇐߹ࠄߥ޿㧘ⶄว⊛ߥᯏ⢻ࠍߚࠄߒ㧘࿾ਅ᳓ߩ⢈ᢱᳪᨴࠍ೥ᷫߒ㧘↢ᘒⅣႺ଻ోߦ߽᦭ߔࠆ᧚ᢱߩวᚑᴺߣߘߩ⹏ଔ㧘․ߦ⍾⾰࿯ფߦᷙวߒነਈߔࠆ߽ߩߣᦼᓙߐࠇࠆ‫ޕ‬╙㧠ㇱ㧘╙㧤┨‫ߪߢޢ⺰⚿ޡ‬㧘ᧄ⎇ⓥߩᚑᨐ߅ࠃ߮ᬌ

ߚ㓙ߩലᨐ߿㊁⩿⢒ᚑߦᔕ↪ߒߚ㓙ߩᬀ‛ᚑ㐳ߦਈ߃ࠆᓇ㗀߹ߢߩ⹏ଔࠍⴕߞߡ޿ࠆ‫ޕ‬⸛੐㗄ߦߟ޿ߡㅀߴߡ޿ࠆ‫ޕ‬╙㧡┨‫ⶄޡ‬วᯏ⢻ᕈ‛⾰㧔଻᳓೷࡮✭ലᕈ⢈ᢱⶄว᧚ ᢱ㧕ߩ⵾ㅧߣ⹏ଔ‫ߪߢޢ‬㧘㕟ᣂ⊛ߥ࠺ࠩࠗࡦߦࠃࠅⶄวએ਄ࠍⷐ⚂ߔࠆߦ㧘᳓ߩ⛘ኻ⊛଻ᜬ㊂߇ዋߥߊ࿯ფߩᯏ⢻ᕈߔߥࠊߜ଻᳓ᕈߣ✭ലᕈ⢈ᢱߩᯏ⢻ࠍᜬߚߖߚⶄ⢈ᴅᐲ߽ᭂ߼ߡૐ޿⍾࿾࿯ფੇ῎࡮ඨੇ῎࿾ၞߢߪ㧘ᬀวᯏ⢻ᕈ‛⾰ߩวᚑࠍⴕߞߡ޿ࠆ‫ߩߘޕ‬ౝㇱߦߪ᭽‫ߥޘ‬‛߇↢⢒ߔࠆߚ߼ߦᔅⷐߥ᳓ߣ⢈ᴅᐲࠍⅣႺߦఝߒ޿⚛

ⓣᓘߩ⚦ሹ᭴ㅧ߇ᒻᚑߐࠇ㧘ᄢ߈ߥ᳇ᵃⓣߦߪ᳓߇㧘ዊ᧚ࠍ↪޿ߡ⏕଻ߔࠆߎߣ߇㕖Ᏹߦ㊀ⷐߢ޽ࠆ‫߼ߚߩߘޕ‬ߐ޿᳇ᵃⓣߦߪⓨ᳇߇⾂⬿ߐࠇࠆ‫ޕ‬᳇ᵃߩ㑆ࠍߐ߹ߑ߹ߦ㧘ᧄ⺰ᢥߢߪ߹ߕ㧘଻᳓ᕈ㧘ㆃലᕈ㧘ⅣႺㆡวᕈߩߘߥᓘߩࡄࠗࡊߢធ⛯ߒߚ᧚ᢱߦ㧘᳓ࠍᶐㅘߐߖߚᓟᬀ‛ࠇߙࠇߩᯏ⢻ࠍᏒ⽼ຠߦᲧߴᡷ⦟ߔࠆߎߣ߇ߢ߈ࠆනᯏࠍᬀ߃ࠆߣ㧘ᩮ♽ߪࡄࠗࡊࠍㅢㆊߒ㧘ᬀ‛ᚑ㐳ߦᔅⷐߥ⢻ᕈ‛⾰ߩ㐿⊒ࠍⴕߞߡ޿ࠆ‫ߦࠄߐޕ‬㧘ߎࠇࠄࠍⶄวൻⓨ᳇㧘᳓㧘ᩕ㙃ಽߩߘࠇߙࠇߦធ⸅ߔࠆߎߣ߇น⢻ߣߥߐߖࠆߣ޿߁⋡⊛ߦㆡߒߚᯏ⢻ࠍ⊒⃻ߐߖߚࡐ࡝࠙࡟࠲ࠅ㧘ੇ῎࿾ߢߩᬀ‛↢↥ߦ᦭ലߢ޽ࠆߣᦼᓙߐࠇߚ‫ޕ‬ࡦࡈࠜ࡯ࡓࠍ⥄ࠄวᚑߒ㧘ߎࠇࠍ㜞ಽሶ☼⌕೷ߣߒߡ↪

╙㧢┨‫ⶄޡ‬วᯏ⢻ᕈ‛⾰ߦࠃࠆ⍾⾰࿯ფᡷ⦟ലᨐߩ⹏޿଻᳓೷ߣ㜞ಽሶ⢈ᢱߥߤࠍ☼⌕ߐߖࠆߎߣߢ㧘ੇ῎࿾ଔ‫ߪߢޢ‬㧘ⶄวᯏ⢻ᕈ‛⾰ࠍ࿯ფߦᷙวߔࠆߎߣߢ㧘ㅘߩᬀ‛↢↥ߦㆡߒߚⶄวᯏ⢻ᕈ‛⾰߇⵾ㅧน⢻ߢ޽ࠆߎ᳓ᕈ㧘଻᳓ᕈࠍᡷༀߒ࿅☸᭴ㅧࠍ߽ߚࠄߔߎߣ߇ឭ᩺ߐࠇߚ‫ޕ‬㠽ข⍾ߦ 0.5%ߩᯏ⢻ᕈ‛⾰ࠍᷙวߒߡ㧘ቯ᳓૏ᴺߣࠍ㧘Ꮢ⽼ߩ଻᳓೷㧘ㆃലᕈ⢈ᢱࠍ↪޿ߡ⏕⹺ߒ㧘ߐࠄ߅ࠃ߮ട࿶᧼ᴺࠍ↪޿ߡㅘ᳓ᕈ㧘଻᳓ᕈߩ⹏ଔࠍⴕߞߚ‫ޕ‬ߩ᷹ቯߣੇ῎࿾ߢߩᬀ‛↢⢒㧘↢↥ታ㛎ࠍㅢߒߡ㧘ታ⸽⍾࿯ფߩ᳇⋧㧘࿕⋧ߪᷫዋ㧘ᶧ⋧ߪჇടߒ㧘⍾࿯ფߩㅘߒߡ޿ࠆ‫ޕ‬ߦߎߩ᦭ലᕈࠍ᭽‫ߥޘ‬ታ㛎㧘ߔߥࠊߜ⍾⾰࿯ფᡷ⦟ലᨐ᳓ᕈߣ଻᳓ᕈߣ߇ᡷༀߐࠇ㧘⍾⾰࿯ფߩᬀ‛ߦࠃࠆ೑↪

ᧄ⺰ᢥߪනᯏ⢻‛⾰߅ࠃ߮ߘࠇࠄߩⶄวൻߦࠃࠆⶄวน⢻᳓㊂߇Ⴧടߒ㧘⍾⾰࿯ფᡷ⦟ലᨐ߇⏕⹺ߐࠇߚ‫ޕ‬㔚ᯏ⢻ᕈ‛⾰㐿⊒߇㧘੹ᓟߩੇ῎࿾ߢߩᬀ‛↢⢒㧘㘩ᢱ↢㧙㧙↥ߩߚ߼ߩ㐿⊒ᛛⴚߩ᭽‫ߥޘ‬ዷ㐿ߩน⢻ᕈࠍ߽ߚࠄߔߎߣࠍᄢ߈ߊ␜ໂߒߡ߅ࠅ㧘ߘߩᎿቇ⊛ᗧ⟵ߪ߈ࠊ߼ߡᄢ߈޿߽ߩߢ޽ࠆ‫ޕ‬ࠃߞߡᧄ⺰ᢥߪඳ჻㧔Ꮏቇ)ߩቇ૏⺰ᢥߦචಽ୯ߔࠆ߽ߩߢ޽ࠆ‫ޕ‬㧙㧙ඳ჻ቇ૏⺰ᢥክᩏⷐᣦᚑ く ᄢ ቇቇ૏ⷙೣ㧔ᤘ๺  ᐕ㧠᦬㧝ᣣᢥㇱ⋭઎╙㧥ภ㧕╙㧤᧦ߩⷙቯߦࠃࠆ౏⴫ࠍ⋡⊛ߣߒߡ㧘ᧄቇߦ߅޿ߡඳ჻ߩቇ૏ࠍ᝼ਈߒߚ⠪ߩ⺰ᢥክᩏߩⷐᣦࠍᰴߩߣ߅ࠅ⊓タߔࠆ‫ޕ‬ቇ૏⸥⇟ภߦઃߒߚਸߪᧄቇቇ૏ⷙೣ╙㧟᧦╙㧠㗄ߦࠃࠆ߽ߩߢ޽ࠆ‫ޕ‬᳁     ฬਅ᪯  ቇቇ૏ߩ⒳㘃ඳ჻㧔Ꮏቇ㧕ቇ૏⸥⇟ภਸ╙  ภቇ૏᝼ਈᐕ᦬ᣣ ᐕ㧟᦬  ᣣቇ૏᝼ਈߩⷐઙቇ૏ⷙೣ╙㧠᧦╙㧞㗄⹥ᒰ⠪ቇ ૏ ⺰ ᢥ 㗴 ⋡ᄤὼࠕࡒࡁᄙ♧߅ࠃ߮૏⟎ㆬᛯ⊛ߦࠕࡒࡁ♧஥㎮ࠍዉ౉ߒߚᨑಽ߆ࠇဳࠕࡒࡁᄙ♧ࠍ↪޿ߚ㜞ಽሶක⮎ߩ㐿⊒⎇ⓥ⺰ ᢥ ክ ᩏ ᆔ ຬਥᩏ ട⮮ ᣿⦟ᆔຬ ዊፉ ♿ᓼ࡮ේ  ▵ሶṚญ ᵏਯ㧔ජ⪲Ꮏᬺᄢቇᢎ᝼㧕ㄭᐕၮ␆⎇ⓥ߿ᔕ↪⎇ⓥ߇⋓ࠎߦߥߞߡ߈ߚ‫ޕ‬㨇⺰ᢥౝኈߩⷐᣦ㨉ࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦߪಝ㓸ᕈ㧘᛫⩶ᕈ㧘⚦⢩⾮ᵴᵴᕈ㧘ࠠ࠴ࡦߪ࠮࡞ࡠ࡯ࠬߦᰴ޿ߢ⥄ὼ⇇ߢᄢ㊂ߦ↢↥ߐࠇ଻᳓ᕈ㧘଻Ḩᕈ㧘ๆ⌕⢻㧘ࠥ࡞ൻ⢻㧘㍲૕ᒻᚑ⢻ߥߤᄙߡ޿ࠆᄙ♧ߢ㧘ߘߩ᭴ㅧߪ࠮࡞ࡠ࡯ࠬߦ㘃ૃߒߡ޿ࠆ‫ޕ‬ጘߦࠊߚࠆ․ᓽ⊛ߥᕈ⾰ࠍ᦭ߒ㧘ߘߩ೑↪ߦะߌߚ⎇ⓥ㎮⁁ߩ᭴ㅧࠍߒߡ߅ࠅ㧘৻ᣇࠠ࠴ࡦߪ N-ࠕ࠮࠴࡞-D-ࠣଦㅴ೷ߣߒߡ㧘᛫⩶ᕈࠍ೑↪ߒ᛫⩶❫⛽߿᛫⩶ࠪ࡯࠻ߩ࡞ࠦࠨࡒࡦ߇㧘ࠠ࠴ࡦࠍ⣕ࠕ࠮࠴࡞ൻಣℂߒߡᓧࠄࠇࠆ⚛᧚ߣߒߡ㧘߹ߚๆ⌕⢻ߦၮߠߊ⢽⢌ๆ෼ᛥ೙ߩߚ߼ߩ

β-1,4 ⚿วߢ⚿วߒߡ޿ࠆ‫ߩࠄࠇߎޕ‬ᄙ♧ࠍ᭴ᚑߒߡ޿ࠆ࠳ࠗࠛ࠶࠻㘩ຠ⚛᧚ߣߒߡ೑↪ߐࠇߡ޿ࠆ‫ࠇߘߦࠄߐޕ‬ࠄ߇቟ోᕈ߿↢૕ㆡวᕈߦఝࠇߡ޿ࠆߎߣ߇᣿ࠄ߆ߦߥන♧ߪ޿ߕࠇ߽᳓㉄ၮߣࡅ࠼ࡠࠠࠪࡔ࠴࡞ၮ߇ࡇ࡜ࡁ࡯

ࠆߦߟࠇ㧘ක⮎ಽ㊁߳೑↪ߔࠆᔕ↪⎇ⓥ߇ᵴ⊒ߦⴕࠊࠇ

ࠬⅣߦࠛࠢࠕ࠻࡝ࠕ࡞⟎឵ߒ㧘ߐࠄߦߎࠇࠄන♧ห჻߇ࠆࠃ߁ߦߥߞߡ߈ߚ‫ޕ‬ᚻⴚߩ❔ว♻㧘ੱᎿ⊹⤏㧘ੱᎿ⣷㧘ࠛࠢࠕ࠻࡝ࠕ࡞ߦ⚿วߒߚᾲജቇ⊛ߦ቟ቯߥ᭴ㅧࠍߒߡ

ߥߤߦ↪޿ࠄࠇߡ޿ࠆ‫ߒ߆ߒޕ‬㧘ࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦߪ৻

ߔߥࠊߜ࠮࡞ࡠ࡯ࠬߪ D-ࠣ࡞ࠦ࡯ࠬ߇ β-1,4 ⚿วߒߚ⋥ࠠ࠻ࠨࡦߪ D-ࠣ࡞ࠦࠨࡒࡦ߇㧘࠮࡞ࡠ࡯ࠬߣోߊหߓ

߇ߥߐࠇߡ޿ࠆ‫ޕ‬ಝ㓸ᕈࠍ೑↪ߒឃ᳓ಣℂߦ߅ߌࠆᴉᲚ

޿ࠆ‫ޕ‬᭴ㅧߩ㘃ૃᕈ߆ࠄ࠮࡞ࡠ࡯ࠬߣࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦ⥸⊛ߥṁᇦߦኻߔࠆṁ⸃ᕈ߇ૐ޿ߣ޿߁ᰳὐ߆ࠄ㧘ᧂߛߩᕈ⾰ߦߪ㘃ૃᕈ߇ߺࠄࠇࠆ߇㧘࠮࡞ࡠ࡯ࠬߪቭ⢻ၮߣߦᧂ೑↪⾗Ḯߣߒߡߘߩᱴߤ߇ᑄ᫈ߐࠇߡ߅ࠅ㧘ᦨ߽ᄙߒߡ᳓㉄ၮߒ߆߽ߚߥ޿߇㧘ࠠ࠴ࡦߪ᳓㉄ၮߩઁߦ N-㊂ߦ೑↪ߐࠇߡ޿ࠆߩߪᵺൻᮏߦ߅ߌࠆಝ㓸೷ߣߒߡߩࠕ࠮࠴࡞ࠕࡒࡁၮࠍ㧘ࠠ࠻ࠨࡦߪࠕࡒࡁၮࠍ᦭ߒߡ޿ࠆ೑↪ߢ㧘߹ߛߘߩ․ᕈࠍචಽߦᵴ↪ߒߡ޿ࠆߣߪ⸒߃ߥߣ޿߁㆑޿߇޽ࠆ‫ߩߎޕ‬ಽሶ᭴ㅧ⊛ߥ․ᓽߩߚ߼㧘ࠠ࠴޿‫ޕ‬ࡦ࡮ࠠ࠻ࠨࡦߪ࠮࡞ࡠ࡯ࠬߦᲧߴߡᄢᄌ⥝๧ᷓ޿‛ᕈ߿ߘߎߢᧄቇ૏⺰ᢥߪ㧘ᄤὼߩࠕࡒࡁᄙ♧ߢ޽ࠆࠠ࠴↢‛ᵴᕈࠍ␜ߒ㧘ᄤὼߩᯏ⢻ᕈ⚛᧚ߣߒߡᵈ⋡ࠍ㓸߼㧘ࡦ࡮ࠠ࠻ࠨࡦߩක⮎ಽ㊁ߦ߅ߌࠆ೑↪ߩน⢻ᕈࠍᐢߍࠆ㧙㧙ߎߣࠍ⋡⊛ߦ㧘ߎࠇ߹ߢߦᱴߤߘߩᯏ⢻ߦߟ޿ߡᬌ⸛߇ߥߐࠇߡ޿ߥ޿ࠗࠞエ↲↱᧪ߩࠠ࠻ࠨࡦࠍ↪޿ߡ߁ⲁ㧔⯻ᱤ㧕੍㒐೷߳ߩ೑↪ߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫ࠠߚ߹ޕ‬ㆬᛯᕈࠍ᦭ߒߡ޿ࠆߎߣ߇␜ߐࠇߚ‫ޕ‬╙㧠┨ߪ㧘‫ࠞࠗޟ‬エ↲↱᧪ࠠ࠻ࠨࡦߩ߁ⲁ੍㒐೷ߣߒߡน⢻ᕈ‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫ ╙ޕ‬3 ┨ߩ⚿ᨐࠍ〯߹߃㧘࠴ࡦ࡮ࠠ࠻ࠨࡦߩṁ⸃ᕈߩᰳὐࠍ⸃᳿ߔࠆߚ߼⺃ዉ૕ߩβ-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦࠍ߁ⲁ੍㒐೷ߣߒߡ೑↪ߔࠆนᬌ⸛ࠍⴕ޿㧘ߎߩ⺃ዉ૕ࠍ↪޿ߡᣂⷙߩᨑಽ߆ࠇဳࠕࡒ⢻ᕈࠍតࠆߎߣࠍ⋡⊛ߦ㧘ࡅ࠻ߢ߁ⲁේ࿃⩶ᢙࠍᷫࠄߔࡁᄙ♧ࠍഃ⵾ߒߘߩ᛫≸ᵴᕈߦߟ޿ߡᬌ⸛ࠍⴕ޿㧘ߘࠇࠄߩၮ␆⊛ߥ⍮⷗ࠍ߹ߣ߼ߚ߽ߩߢ޽ࠆ‫ޕ‬ലᨐ߇޽ࠆߩ߆ߤ߁߆㧘⥃ᐥ⹜㛎ࠍታᣉߒߚ‫ⵍޕ‬ᬌ⠪ 3ฬߢ⹜㛎ࠍታᣉߒߚ⚿ᨐ㧘3 ฬߣ߽ࠠ࠻ࠨࡦ 2 ㅳ㑆ಣℂᧄቇ૏⺰ᢥߪ 10 ┨߆ࠄߥߞߡ߅ࠅ㧘╙ 1 ┨ߢߪߎࠇߦࠃߞߡ㧘ญ⣧ౝߩ✚࡟ࡦࠨ⃿⩶ᢙߦኻߔࠆ߁ⲁේ࿃⩶߹ߢߩࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦߩ⎇ⓥႎ๔ࠍ⸃⺑ߒߥ߇ࠄ㧘ᧄᢙߩභ߼ࠆഀวߪ᦭ᗧߦᷫዋߒߚ‫⚿ߩߎޕ‬ᨐߪ㧘ࡅ࠻ߩ⎇ⓥߩ⋡⊛ߣᗧ⟵ߦߟ޿ߡㅀߴߡ޿ࠆ‫ޕ‬ญ⣧ౝߩ࡟ࡦࠨ⃿⩶ߦኻߒߡ β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦߪ╙㧞┨ߪ‫ࠞࠗޟ‬エ↲↱᧪ࠠ࠻ࠨࡦߩ࠙ࠪⴊᷡࠕ࡞ࡉࡒㆬᛯ⊛ߦ૞↪ߔࠆߎߣࠍ␜ໂߒߡ߅ࠅ㧘β-ࠠ࠴ࡦ↱᧪ߩࡦߣߩಝ㓸ᕈ‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫᧪↱࠾ࠞ߿ࡆࠛޕ‬㧔α-ࠠ࠻ࠨࡦߪ߁ⲁ੍㒐೷ߣߒߡ೑↪น⢻ߢ޽ࠆߎߣ߇᣿ࠄࠠ࠴ࡦ↱᧪㧕ߩࠠ࠻ࠨࡦߣ߿߿㆑ߞߚ․ᕈࠍ᦭ߔࠆࠗࠞ߆ߣߥߞߚ‫ޕ‬エ↲↱᧪㧔β-ࠠ࠴ࡦ↱᧪㧕ߩࠠ࠻ࠨࡦߩᯏ⢻․ᕈࠍ᣿ࠄ╙㧡┨ߪ㧘‫ޟ‬ᣂⷙߥᒻᘒࠍ᦭ߔࠆ㕖᥏ᕈߩౣᴉᲚࠠ࠻ࠨ߆ߦߔࠆߎߣࠍ⋡⊛ߦ㧘ಝ㓸ᕈߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫ޕ‬ࡦ‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫ߩࡦࠨ࠻ࠠޕ‬෻ᔕᕈࠍᡷༀߔࠆߔߥࠊߜ㧘࠙ࠪⴊᷡࠕ࡞ࡉࡒࡦ㧔BSA㧕ߣߩಝ㓸ᕈߦߟ޿ߡ㧘β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦߣ α-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨߎߣࠍ⋡⊛ߦౣᴉᲚߩᚻᴺߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫࠻ࠠޕ‬ࠨࡦࠍ 2 % ㈶㉄ṁᶧߦṁ⸃ᓟ㧘5 % ᳓㉄ൻ࠽࠻࡝࠙ࡓࡦߩᲧセࠍⴕߞߚ‫ޕ‬᭽‫ߥޘ‬ૐಽሶ㊂ߩࠠ࠻ࠨࡦࠍ⺞⵾ߔṁᶧߦṢਅߒ㧘ᦨㆡ᧦ઙਅߢᴉᲚ‛ߣߒߡ࿁෼ߒಓ⚿ੇࠆߚ߼㧘Ⴎ㉄ߣ᳓㉄ൻ࠽࠻࡝࠙ࡓࠍ↪޿ߚᓥ᧪ߩൻቇ⊛῎ࠍⴕ޿㧘ౣᴉᲚࠠ࠻ࠨࡦߣߒߡ✎ߩࠃ߁ߥ❫⛽⁁ࠠ࠻

ᣇᴺࠍ↪޿ߡૐಽሶൻࠍⴕߞߚ⚿ᨐ㧘β-ࠠ࠴ࡦ↱᧪ߩࠠࠨࡦࠍᓧߚ‫ޕ‬ౣᴉᲚࠠ࠻ࠨࡦߩ X ✢⸃ᨆߩ⚿ᨐ㧘⚿᥏᭴࠻ࠨࡦߩૐಽሶൻߪ α-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦࠃࠅⓏ๺

ㅧߪᒙ߹ࠅ㕖᥏ᕈߩ‛⾰ߣߥߞߚߎߣ߇᣿ࠄ߆ߣߥࠅ㧘ߥ᧦ઙߢⴕ߃ࠆߎߣ߇ࠊ߆ߞߚ‫ߚ߹ޕ‬㧘β-ࠠ࠴ࡦ↱᧪ߩࠝ࡝ࠫ࠽࡞ߩࠠ࠻ࠨࡦࠃࠅⓏ๺ߥ᧦ઙߢൻቇ෻ᔕ߇ㅴⴕ

ࠠ࠻ࠨࡦߣ BSA ߣߩಝ㓸ᕈߪࠠ࠻ࠨࡦߩỚᐲ㧘ಽሶ㊂߅ࠃ߮ṁᶧߩ pH ߿౒ሽߔࠆႮỚᐲߩᓇ㗀ࠍᒝߊฃߌࠆߔࠆߎߣࠍ⷗಴ߒߚ‫ߜࠊߥߔޕ‬㧘ቢోߦ N-ࠕ࠮࠴࡞ൻߐࠇߚࠠ࠴ࡦࠍ⺞⵾ߔࠆߚ߼ߩේᢱߣߒߡ㧘߹ߚ࠻࡝࠴࡞࿷ߔࠆߎߣ߇␜ߐࠇߚ‫․ߩࠄࠇߎޕ‬ᕈߪ α-ࠠ࠴ࡦ↱᧪ߩൻ෻ᔕߩ಴⊒ේᢱߣߒߡߩ᦭↪ᕈ߇␜ߐࠇߚ‫ߩࠄࠇߎޕ‬ࠠ࠻ࠨࡦߣ߶߷ห╬ߢ޽ߞߚ߇㧘ಝ㓸ᕈߩᒝߐߣ޿߁ὐ࠻ࠨࡦ޽ࠆ޿ߪߘࠇࠄߩ⺃ዉ૕ࠍวᚑߔࠆߚ߼ߩఝࠇߚߎߣ߇್᣿ߒ㧘ಝ㓸ᕈߩᒝᒙߦߪߘࠇࠄߩᦨㆡ᧦ઙ߇ሽ

ߢߪ β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦߩᣇ߇ α-ࠠ࠴ࡦ↱᧪ߩࠠ࠻⚿ᨐ߆ࠄ㧘ౣᴉᲚࠠ࠻ࠨࡦߪ᭴ㅧ⊛ߦ᣿⏕ߥࠠ࠴ࡦ࡮ࠠේᢱߢ޽ࠆߎߣ߇␜ߐࠇߚ‫ޕ‬╙㧢┨ߪ㧘‫♖ޟ‬ኒߥൻቇୃ㘼ࠍⴕ߁ߚ߼ߩ෻ᔕ೨㚟૕ࡈࠨࡦࠃࠅ⧯ᐓᒝ޿ߎߣ߇ࠊ߆ߞߚ‫ޕ‬╙㧟┨ߪ‫ࠞࠗޟ‬エ↲↱᧪ࠠ࠻ࠨࡦߩ߁ⲁේᕈ࡟ࡦࠨ⃿࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦߩวᚑߣߘߩ⹏ଔ‫ߡ޿ߟߦޠ‬ㅀߴߡ⩶ߦኻߔࠆ᛫⩶૞↪‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫ޕ‬β-ࠠ࠴ࡦ↱޿ࠆ‫ߩࡦࠨ࠻ࠠޕ‬ṁ⸃ᕈߩᡷༀߣ૏⟎ㆬᛯ⊛ߥ⺃ዉ૕ൻ᧪ߩࠠ࠻ࠨࡦߩᯏ⢻․ᕈࠍ᣿ࠄ߆ߦߔࠆߎߣࠍ⋡⊛ߦ㧘ࠍⴕ߁ߚ߼ߩ෻ᔕ೨㚟૕ߩ㐿⊒ࠍ⋡⊛ߣߒߚ‫ޕ‬፾㜞޿ࡈߎߎߢߪ᛫⩶ᕈߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫ߜࠊߥߔޕ‬㧘߁ⲁ࠲ࡠࠗ࡞ၮࠍዉ౉ߔࠆߎߣߢṁ⸃ᕈ߇ᡷༀߐࠇࠆߣ⠨߃㧘㧔⯻ᱤ㧕ේ࿃⩶ߦኻߔࠆ᛫⩶ᕈߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫ޕ‬

߁ⲁේ࿃⩶ࡒࡘ࡯࠲ࡦࠬ࡟ࡦࠨ⃿⩶㧔S. mutans ߣ S.
sobrinus㧕ࠍ฽߼ߚญ⣧Ᏹ࿷࡟ࡦࠨ⩶ߦኻߒ㧘5 µg/mLߩỚᐲߩࠠ࠻ࠨࡦṁᶧࠍ↪޿ߡ᛫⩶ᕈࠍ⺞ߴߚ⚿ᨐ㧘ߘ
ߩ᛫⩶ᕈߪోߡߩญ⣧Ᏹ࿷࡟ࡦࠨ⃿⩶ߦኻߒߡ⊒⃻ߐࠇ

N-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦߩวᚑࠍⴕߞߚ‫ޕ‬N,N-ࠫࡔ࠴࡞ࡎ࡞ࡓࠕࡒ࠼㧔DMF㧕ਛ㧘120 ͠ߢࠠ࠻ࠨࡦߩࡈ࠲ࡠࠗ࡞ൻࠍⴕߞߚ⚿ᨐ㧘ࡈ࠲ࡠࠗ࡞ၮߪࠕࡒࡁၮߛߌߢߪߥ

ߊ C-6 ૏ߩ᳓㉄ၮߦ߽ዉ౉ߐࠇߚ‫ߒ߆ߒޕ‬෻ᔕߩㅴⴕߦ઻޿᳓߇↢ᚑߒ㧘ߎߩᓇ㗀ߢ C-6 ૏ߩࡈ࠲ࡠࠗ࡞ၮߪಾ

ߚ߇㧘⩶⒳ߦࠃߞߡㆬᛯᕈ߇⹺߼ࠄࠇ㧘S. mutans ߣ S.

ᢿߐࠇࠆߎߣࠍ⓭߈ᱛ߼ߚ‫ߢߎߘޕ‬㧘DMF/H2O ᷙว♽ࠃࠅ߽ᒝ߆ߞߚ‫৻ޕ‬ᣇ㧘α-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦ߽ห᭽ᨐ㧘ࠕࡒࡁၮߦ૏⟎ㆬᛯ⊛ߦࡈ࠲ࡠࠗ࡞ၮࠍዉ౉ߢ߈ࠆsobrinus ߦኻߔࠆ᛫⩶ᕈߪ㧘㕖߁ⲁේ࿃⩶ߦኻߔࠆߘࠇ
ߦ S. mutans ߣ S. sobrinus ߦኻߒߡ᛫⩶ᕈࠍ⊒⃻ߒߚ߇㧘β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦ߶ߤㆬᛯᕈߪ᣿⏕ߢߪߥ߆ߞߚ‫⚿ߩࠄࠇߎޕ‬ᨐ߆ࠄ㧘β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦߩญ⣧࡟ࡦࠨ⃿⩶ߦኻߔࠆ᛫⩶ᕈߪ㧘ᣢሽߩ᛫⩶೷ߦߪߥ޿

㧔ᦨㆡᷙวᲧߪ 95㧦5㧕ߢࡈ࠲ࡠࠗ࡞ൻ෻ᔕࠍⴕߞߚ⚿ߎߣࠍ⷗಴ߒ㧘৻Ბ㓏ߩ෻ᔕߢ N-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦࠍᓧࠆวᚑ⚻〝ࠍ㐿⊒ߒߚ‫ ߩߎޕ‬N-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨ

ࡦߪࠫࠢࡠࡠ㈶㉄㧘m-ࠢ࡟࠱࡯࡞㧘8 % Ⴎൻ࡝࠴࠙ࡓ฽᦭ N,N-ࠫࡔ࠴࡞ࠕ࠮࠻ࠕࡒ࠼㧘㘻๺Ⴎൻࠞ࡞ࠪ࠙ࡓࠍ฽㧙㧙߻ࡔ࠲ࡁ࡯࡞ߥߤߩṁᇦߦṁ⸃ߒߚ‫ߩߎߚ߹ޕ‬෻ᔕ೨㚟ߐࠇߡ޿ߚ‫ߒ߆ߒޕ‬ಽጘဳࠠ࠻ࠨࡦߩಝ㓸ߩ⒟ᐲߪ⟎឵૕ࠍ↪޿ߡ࠻࡝࠴࡞ൻ෻ᔕࠍⴕ޿㧘C-6 ૏ࠍ૏⟎ㆬᛯ⊛ᐲߩᓇ㗀ࠍฃߌ㧘⟎឵ᐲߩჇടߦ઻޿ᷫዋߒߚ‫⟎ޕ‬឵ᐲߦ࠻࡝࠴࡞ൻߢ߈ࠆߎߣࠍ␜ߒߚ‫⚿ߩࠄࠇߎޕ‬ᨐ߆ࠄ㧘ߩ਄᣹ߦ઻߁࡝࠱࠴࡯ࡓߦࠃࠆಽ⸃ᕈߩૐਅߣ BSA ߣN-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦߪࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦࠍ૏⟎ㆬᛯߩಝ㓸ᕈߩૐਅߪ㧘஥㎮ߣߒߡዉ౉ߐࠇߚ♧ߩ፾㜞ߐ߇⊛ߦൻቇୃ㘼ߔࠆߚ߼ߩఝࠇߚ෻ᔕ೨㚟૕ߢ޽ࠆߎߣ߇

ᓇ㗀ߒߡ޿ࠆ߽ߩߣផኤߒߚ‫ߦࠄߐޕ‬ಽጘဳࠠ࠻ࠨࡦߩ

᣿ࠄ߆ߣߥߞߚ‫    ޕ‬

᛫⩶ᕈߦߟ޿ߡᬌ⸛ߒߚ⚿ᨐ㧘B. subtilis 㧘S. aureus 㧘╙㧣┨ߪ‫࡞ࠗࡠ࠲ࡈࡠࡠࠢࠫߩࡦࠨ࠻ࠠޟ‬ൻߦࠃࠆൻ

C. albicans㧘E. coli㧘P. aeruginosa ߅ࠃ߮ S. mutansቇㆬᛯ⊛଻⼔ᴺߩ㐿⊒‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫ࡦࠨ࠻ࠠޕ‬ߦኻߒࠠ࠻ࠨࡦߣห⒟ᐲߩ᛫⩶ᕈࠍ⊒⃻ߒߚ‫ޕ‬ಽጘဳࠠߩ଻⼔࡮⣕଻⼔෻ᔕࠍⓏ๺ߥ᧦ઙਅߢⴕ߁ߚ߼ߦ㧘N-ࠫ࠻ࠨࡦߪਛᕈߩ᳓ߦṁ⸃ߔࠆߎߣ߆ࠄ㧘᳓ṁᕈߩᣂߚߥࠢࡠࡠࡈ࠲ࡠࠗ࡞ൻߦߟ޿ߡᬌ⸛ࠍⴕߞߚ‫ޕ‬ㅢᏱ㧘ࠠ࠻

᛫⩶೷ߣߒߡߩน⢻ᕈ߇␜ߐࠇߚ‫ޕ‬ಽጘဳࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦߩ଻⼔࡮⣕଻⼔෻ᔕߪૐಽሶൻࠍ઻߁ߚ߼㧘Ⓩ๺ߥࠨࡦߩ᭴ㅧߪ᛫≸೷ߣߒߡ↪޿ࠄࠇߡ޿ࠆᄤὼߩᨑಽ߆᧦ઙਅߢ଻⼔࡮⣕଻⼔߇น⢻ߥ෻ᔕ೨㚟૕ߩ㐿⊒߇ᦸ߹ࠇဳᄙ♧ߢ޽ࠆ࡟ࡦ࠴࠽ࡦ߿ࠪ࠱ࡈࠖ࡜ࡦߣ᭴ㅧ߇ૃߡࠇࠆ‫ߢߎߘޕ‬㧘ࡈ࠲ࡠࠗ࡞ၮࠃࠅ߽ߐࠄߦ፾㜞޿ࠫࠢࡠ޿ࠆߎߣ߆ࠄ㧘᛫≸ᵴᕈߦߟ޿ߡ࡟ࡦ࠴࠽ࡦߣᲧセߒߚ‫ޕ‬ࡠࡈ࠲ࡠࠗ࡞ၮࠍࠠ࠻ࠨࡦߦዉ౉ߒ㧘ߘߩ଻⼔࡮⣕଻⼔ߘߩ⚿ᨐ㧘ಽጘဳࠠ࠴ࡦ߅ࠃ߮ಽጘဳࠠ࠻ࠨࡦߪࡑࠢࡠߩ෻ᔕ᧦ઙߩᬌ⸛ߣ෻ᔕ೨㚟૕ߣߒߡߩ⹏ଔࠍⴕߞߚ‫ޕ‬ࡈࠔ࡯ࠫࠍ⋥ធᵴᕈൻߒ⣲≌უᱫ࿃ሶ㧔TNF-α㧕ߣ৻㉄ࡈ࠲ࡠࠗ࡞ൻߣห᭽ߦ DMF/H2O㧔95㧦5㧕ߩᷙวṁᇦਛ㧘ࠠ࠻ࠨࡦߩࠫࠢࡠࡠࡈ࠲ࡠࠗ࡞ൻ෻ᔕࠍⴕ޿㧘৻Ბ㓏ߩ෻ᔕߢࠕࡒࡁၮߦ૏⟎ㆬᛯ⊛ߦࠫࠢࡠࡠࡈ࠲ࡠࠗ࡞
ၮࠍዉ౉ߒ㧘N-ࠫࠢࡠࡠࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦࠍᓧߚ‫ޕ‬N-ࠫࠢࡠࡠࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦߩ⣕଻⼔ߩ᧦ઙߪ㧘N-ൻ⓸⚛㧔NO㧕ߩ↥↢ࠍ⺃ዉߔࠆߎߣࠍ⷗಴ߒߚ‫ޕ‬ಽጘဳࠠ࠴ࡦߩೝỗߦࠃߞߡ↥↢ߐࠇߚ TNF-α ㊂ߪ࡟ࡦ࠴࠽ࡦߩ⚂ 250 ୚㧘ಽጘဳࠠ࠻ࠨࡦߩߘࠇߪ࡟ࡦ࠴࠽ࡦߩ

⚂ 1400 ୚ߢ޽ߞߚ‫․ߩࠄࠇߎޕ‬ᕈߪࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦߦߪߥ޿ߎߣ߆ࠄ㧘஥㎮ߣߒߡ♧߇ዉ౉ߐࠇߚߎߣߦ↱ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦߩ⣕଻⼔ߩ᧦ઙࠃࠅ⧯ᐓ෩ߒ޿᧦᧪ߔࠆߎߣ߇ࠊ߆ߞߚ‫ ߚ߹ޕ‬RAW264.7 ⚦⢩㧔ࡑ࠙ࠬࡑઙߢ޽ߞߚ߇㧘C-6 ૏ࠍ૏⟎ㆬᛯ⊛ߦൻቇୃ㘼ߔࠆ෻ᔕࠢࡠࡈࠔ࡯ࠫ᭽⚦⢩㧔TNF-α ↥↢ᩣ㧕㧕㧘L929 ⚦⢩ߦ߅޿ߡߪ㧘N-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦࠃࠅ㜞޿෻ᔕᕈࠍ

Vero ⚦⢩㧔ࠕࡈ࡝ࠞࡒ࠼࡝ࠩ࡞㧘⣢⤳਄⊹⚦⢩㧕㧘
Mv.1.Lu␜ߒ㧘N-ࠫࠢࡠࡠࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦ߽ N-ࡈ࠲ࡠࠗ㧘㧔TNF-α ᗵฃᕈᩣ㧕
㧘B16 ⚦⢩㧔ࡑ࠙ࠬࡔ࡜ࡁ࡯ࡑ⚦⢩㧕࡞ൻࠠ࠻ࠨࡦߣห᭽ߦࠠ࠴ࡦ࡮ࠠ࠻ࠨࡦࠍ૏⟎ㆬᛯ⊛ߦ⚦⢩㧔ࡒࡦࠢ㧘⢖਄⊹⚦⢩㧕߅ࠃ߮ WI-38 ⚦⢩㧔ࡅ࠻⢝ൻቇୃ㘼ߔࠆߚ߼ߩఝࠇߚ෻ᔕ೨㚟૕ߢ޽ࠆߎߣ߇᣿ࠄఽ⢖㧘❫⛽⧘⚦⢩㧕ߩฦ⒳⚦⢩ߦኻߔࠆ⚦⢩Ქᕈߪ࡟ࡦ߆ߣߥߞߚ‫    ޕ‬࠴࠽ࡦࠃࠅ߿߿ᒝ߆ߞߚ߽ߩߩ߶߷ห╬ߢ޽ߞߚ‫ࠇߎޕ‬╙㧤┨ߪ㧘‫ޟ‬㕖ᄤὼဳಽጘဳࠠ࠴ࡦ߅ࠃ߮ࠠ࠻ࠨࡦߩวࠄߩ⚿ᨐ߆ࠄಽጘဳࠠ࠴ࡦ߅ࠃ߮ࠠ࠻ࠨࡦߪ࡟ࡦ࠴࠽ࡦᚑߣ᛫≸೷ߣߒߡߩࡑࠢࡠࡈࠔ࡯ࠫᵴᕈൻ⢻‫ߡ޿ߟߦޠ‬ห᭽ૐᲥᕈߩ᛫≸೷ߣߒߡ೑↪น⢻ߢ޽ࠆߎߣ߇ࠊ߆ߞㅀߴߡ޿ࠆ‫ࡁࡒࠕޕ‬ᄙ♧ߦᣂߚߥᯏ⢻ࠍઃਈߔࠆߎߣࠍߚ‫ޕ‬⋡⊛ߦ㧘N-ࡈ࠲ࡠࠗ࡞ൻࠠ࠻ࠨࡦࠍ↪޿ߡᨑಽ߆ࠇဳࠠ╙㧥┨ߪ‫ޟ‬N-ࠕ࠮࠴࡞-D-ࠣ࡞ࠦࠨࡒࡦࠍ஥㎮ߦᜬߟ࠴ࡦ߅ࠃ߮ᨑಽ߆ࠇဳࠠ࠻ࠨࡦߩวᚑࠍⴕߞߚ‫ޕ‬N-ࡈ࠲㕖ᄤὼဳᨑಽ߆ࠇဳࠞ࡯࠼࡜ࡦߩഃ⵾ߣ᛫≸೷ߣߒߡߩ࠮࠴࡞ၮߢ଻⼔ߒ㧘ߘߩᓟ C-6 ૏ࠍ⣕࠻࡝࠴࡞ߒ㧘ߎࠇน⢻ᕈ‫ߡ޿ߟߦޠ‬ㅀߴߡ޿ࠆ‫ޕ‬ᨑಽ߆ࠇဳᄙ♧ߩ᭴ㅧ-ࡠࠗ࡞ൻࠠ࠻ࠨࡦߩ C-6 ૏ࠍ࠻࡝࠴࡞ൻᓟ㧘C-3 ૏ࠍࠕᵴᕈ⋧㑐ࠍ⺞ߴࠆ⋡⊛ߢ㧘࡟ࡦ࠴࠽ࡦߩਥ㎮ߢ޽ࠆࠞ࡯ࠍ♧ฃኈ૕ߣߒߡ↪޿㧘ࠣ࡞ࠦࠨࡒࡦ↱᧪ࡄ࡯ࠕ࠮࠴࡞

࠼࡜ࡦ㧔β-1,3 ࠣ࡞ࠞࡦ㧕ߦ஥㎮ߣߒߡ N-ࠕ࠮࠴࡞-D-ࠝࠠࠨ࠱࡝ࡦ⺃ዉ૕ߩࠣ࡝ࠦࠪ࡞ൻ෻ᔕࠍⴕ޿㧘C-6 ૏ࠣ࡞ࠦࠨࡒࡦࠍዉ౉ߒߚಽᨑဳࠞ࡯࠼࡜ࡦࠍഃ⵾ߒߚ‫ޕ‬ߦ D-ࠣ࡞ࠦࠨࡒࡦ஥㎮ߦᜬߟಽጘဳࠠ࠻ࠨࡦࠍวᚑߒߚ‫࡞࠴࠮ࠕࠍࠇߎޕ‬ൻಣℂߒ㧘C-6 ૏ߦ N-ࠕ࠮࠴࡞-Dࠣ࡞ࠦࠨࡒࡦ஥㎮ߦᜬߟಽጘဳࠠ࠴ࡦࠍวᚑߒߚ‫ࠇߎޕ‬ࠄߩᯏ⢻․ᕈߦߟ޿ߡᬌ⸛ߒߚ⚿ᨐ㧘ಽጘဳࠠ࠴ࡦߪࠠ࠴ࡦߣห᭽ߦ࡝࠱࠴࡯ࡓߦࠃߞߡಽ⸃ߐࠇ㧘↢ಽ⸃ᕈࠍࠞ࡯࠼࡜ࡦߩ C-6 ૏ࠍ࠻࡝࠴࡞ၮߢ଻⼔ߒ㧘ࡈࠚ࠾࡞ࠗ࠰ࠪࠕ࠽࡯࠻ࠍ↪޿ߡ C-2 ૏ߣ C-4 ૏ߦࡈࠚ࠾࡞ࠞ࡞ࡃ

ࡕࠗ࡞ၮࠍዉ౉ߒ㧘2,4-ࠫ-O-ࡈࠚ࠾࡞ࠞ࡞ࡃࡕࠗ࡞-6-O-࠻࡝࠴࡞ࠞ࡯࠼࡜ࡦࠍวᚑߒ㧘ߘߩᓟ C-6 ૏ࠍ⣕଻⼔ߒ㧘♧஥㎮ዉ౉ߩ೨㚟૕ߣߒߡࠞ࡯࠼࡜ࡦߩ C-6 ૏ߩߺߦㆆ᦭ߔࠆߎߣ߇␜ߐࠇߚ‫ޕ‬ಽጘဳࠠ࠴ࡦߩಽ⸃ߩ⒟ᐲߪ⟎㔌ߩ᳓㉄ၮࠍᜬߟ 2,4-ࠫ-O-ࡈࠚ࠾࡞ࠞ࡞ࡃࡕࠗ࡞ࠞ࡯឵ᐲߩᓇ㗀ࠍฃߌ㧘⟎឵ᐲߩჇടߦ઻޿ᷫዋߒߚ‫ߚ߹ޕ‬࠼࡜ࡦࠍวᚑߒߚ‫ߡ޿↪ࠍࠇߎޕ‬㧘ࠣ࡞ࠦࠨࡒࡦ↱᧪ߩߣห᭽ߦ BSA ߣಝ㓸ߒ㧘࠲ࡦࡄࠢ⾰ߣߩಝ㓸ᕈߪ⛽ᜬࠝࠠࠨ࠱࡝ࡦ⺃ዉ૕ߣࠣ࡝ࠦࠪ࡞ൻ෻ᔕࠍⴕ޿㧘ߘߩᓟ

BSA ߣಽጘဳࠠ࠻ࠨࡦߩಝ㓸ᕈࠍ⺞ߴߚ⚿ᨐ㧘ࠠ࠻ࠨࡦࡈࠚ࠾࡞ࠞ࡞ࡃࡕࠗ࡞ၮࠍ⣕଻⼔ߒ㧘C-6 ૏ߦ஥㎮ߣߒ㧙㧙ߡ N-ࠕ࠮࠴࡞-D-ࠣ࡞ࠦࠨࡒࡦࠍᜬߟಽᨑဳࠞ࡯࠼࡜ࡦࠍวᚑߒߚ‫ߩߎޕ‬ಽᨑဳࠞ࡯࠼࡜ࡦ߽ಽጘဳࠠ࠴ࡦ㧘ࠠ࠻ࠨࡦห᭽ࡑࠢࡠࡈࠔ࡯ࠫࠍ⋥ធᵴᕈൻߒ㧘TNF-α ߩ↥↢ࠍ⺃ዉߒߚ‫↢↥ߩߘޕ‬㊂ߪ࡟ࡦ࠴࠽ࡦߩ⚂ 2500 ୚ߢ޽ߞߚ‫╙ޕ‬㧤┨ߣ╙㧥┨ߩ⚿ᨐ߆ࠄ㧘᛫≸ᕈࠍ⊒⃻ߔࠆߚ߼ߦߪ㧘஥㎮ߩ♧߇㕖Ᏹߦ㊀ⷐߢ޽ࠅ㧘ߘߩᒝᒙߦߪ⟎឵ᐲ߇ᓇ㗀ߒߡ޿ࠆߎߣ߇ᒝߊ␜ໂߐࠇߚ‫ ߚ߹ޕ‬N-

ࠕ࠮࠴࡞-D-ࠣ࡞ࠦࠨࡒࡦࠍᜬߟಽᨑဳࠞ࡯࠼࡜ࡦߪ Nࠕ࠮࠴࡞-D-ࠣ࡞ࠦࠨࡒࡦࠍᜬߟಽጘဳࠠ࠴ࡦࠃࠅᒝߊ
ࡑࠢࡠࡈࠔ࡯ࠫࠍᵴᕈൻߒߚߎߣ߆ࠄ㧘ਥ㎮ߩ♧߽ᵴᕈൻ⢻ߦߪ㊀ⷐߢ޽ࠆߎߣ߇␜ໂߐࠇߚ‫ߦࠄߐޕ‬ಽᨑဳࠞ࡯࠼࡜ࡦߩ⚦⢩Ქᕈߪ࡟ࡦ࠴࠽ࡦߣ߶߷ห╬ߢૐ߆ߞߚ‫ޕ‬ߎࠇࠄߩ⚿ᨐ߆ࠄ㧘N-ࠕ࠮࠴࡞-D-ࠣ࡞ࠦࠨࡒࡦࠍ஥㎮ߦᜬߟಽᨑဳࠞ࡯࠼࡜ࡦߪ᛫≸೷ߣߒߡ೑↪ߢ߈ࠆน⢻ᕈ߇ᒝߊ␜ߐࠇߚ‫ޕ‬╙ 10 ┨ߪ‫✚ޟ‬᜝‫ࠅ޽ߢޠ‬㧘ᧄ⎇ⓥߢᓧࠄࠇߚ⚿ᨐߦߟ޿ߡ߹ߣ߼ߡ޿ࠆ‫ᦨޕ‬ᓟߦ‫⺰ޟ‬ᢥ⋡㍳‫ߡߒߣޠ‬㧘࡟ࡈࠚ࡝࡯ઃቇⴚ⺰ᢥࠍઃ⸥ߒߡ޿ࠆ‫ޕ‬એ਄ߩࠃ߁ߦ㧘β-ࠠ࠴ࡦ↱᧪ߩࠠ࠻ࠨࡦߪ߁ⲁ੍㒐೷ߣߒߡ೑↪น⢻ߢ޽ࠆߎߣ߇᣿ࠄ߆ߦߥߞߚ‫ޕ‬߹ߚ㧘⒳‫ޘ‬ߩൻቇୃ㘼ᴺࠍ㚟૶ߒߡ⺞⵾ߒߚ㕖ᄤὼဳߩᨑಽ߆ࠇဳࠕࡒࡁᄙ♧ߪᣂⷙߥ᛫≸೷ߣߒߡ೑↪น⢻ߢ޽ࠆߎߣ߽᣿ࠄ߆ߦߔࠆߎߣ߇ߢ߈ߚ‫⎇ᧄߦࠄߐޕ‬ⓥߢߪ᭴ㅧ߇᣿
⏕ߥᄙ♧ࠍ↪޿ߚߚ߼㧘᭴ㅧ─ᵴᕈ⋧㑐ߦ㑐ߔࠆၮ␆⊛ߢ᦭⋉ߥ⍮⷗ࠍឭଏߔࠆߎߣ߇ߢ߈ߚ‫ޕ‬ࠃߞߡ㧘ᧄ⺰ᢥߪඳ჻㧔Ꮏቇ㧕ߩቇ૏⺰ᢥߣߒߡలಽଔ୯߇޽ࠆ߽ߩߣ⹺߼ࠆ‫ޕ‬㧙㧙