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WELCOME

Greetings from a head investigator of the research team of “neo-self”
Welcome to The 1st International Symposium on “NEO-SELF” in Awaji
Island. The purpose of this symposium is to discuss how pathogenic T cells
and B cells are generated during the course of various immune diseases.
What is “neo-self” in the first place? Many studies have been conducted with the belief that
autoimmune disease and allergy are the abnormal immune responses against “self” and “non-self”,respectively. However, recent findings suggested that there must be other forms of immune-cellrecognition. This idea has come from the results suggesting that complex between peptide antigen andMHC (pMHC) is not a simple structure that had been appreciated. Instead, other forms of pMHC havebeen found, which was unexpected in a classical immunological view of “self” vs. “non-self”. Basedon these findings, we thought that it would be important to elucidate the exact nature of pMHC in aquantitative and qualitative way with a proposal of a novel concept of “neo-self”. The project has been
supported by Grants-in-Aid for Scientific Research, Japan Society for the promotion of science (JSPS)
KAKENHI since 2016. The research team consists of 7 planned research groups and 21 publicly
offered groups.
In this symposium, we will discuss on a fundamental issue of immunology: How immune
cells are recognizing both foreign antigens and those of our own body during the immune response. It
is our great pleasure to have two distinguished guests in the symposium: Prof. Jamie Rossjohn fromMonash University and Prof. Kenneth Murphy from Washington University in St. Louis. I am hopingthat this great opportunity will accelerate the exchange of many interesting ideas in order to elucidate
what exactly “neo-self” is.
Sincerely yours
Mitsuru Matsumoto, M.D., Ph.D.

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The 1st International Symposium on NEO-SELF
DATE

July.10（Tue）〜 11（Wed）, 2018

VENUE Awaji Yumebutai International Conference Center, Reception Hall B
1 Yumebutai, Awaji City, Hyogo 656-2306 Japan
Phone: 81-799-74-1020
http://www.yumebutai.org/english/index.html
REGISTRATION
Location: Awaji Yumebutai International Conference Center, Foyer of Reception Hall B
Day/Date/Hours: Tuesday, 10 July, 11:30 – 18:30
Wednesday, 11 July, 8:30 – 11:00
All the participants are asked to wear name tags at the symposium site. Please return thename tag holder after the symposium is over.
Please pay the accommodation fee and welcome reception fee in Japanese yen uponregistration.
LODGING
THE WESTIN AWAJI ISLAND RESORT & CONFERENCE CENTER
2 Yumebutai, Awaji City, Hyogo 656-2306 Japan
Phone: 81-799-74-1111
http://www.westin-awaji.com/en/
Check-In Scheduled Time and Place: Tuesday, 10 July, 17:50 – 18:20 at Foyer of Reception
Hall B
Check-Out Time and Place: Wednesday, 11 July, until 11:00 at Front Desk in The WESTIN
HotelINTERNET ACCESSReception Hall B - Network Name: ‘115’, Password: Unnecessary
Foyer of Reception Hall B - Network Name: ‘RB’, Password: Unnecessary
The Westin Hotel 2F - Network Name: ‘westin-awaji-guest’, Password: Unnecessary
The Westin Hotel Guest Rooms – Both network name and password are written in the blackbook in each room.
SPEAKER INFORMATION
Speaker Check-In: Please preview your slides at the console beside the podium in Reception
Hall B prior to the break before your session. You can familiarize yourself with the laser
pointer and stage set-up.
Presentation Guidelines: Oral presentation is scheduled to be 20 minutes in talk plus questions
and answers. Please prepare your personal laptops, conversion connector, AC power cordconnector, and VGA D-Sub 15 pin connector or HDMI connector.
SCIENTIFIC DATA
Please note that many of the findings in presentations are being disclosed prior to publication.
All information communicated by presenters should be considered “personal communication.”
Please seek permission from the presenter before quoting unpublished research results orusing data as a basis for further investigations.
** PHOTOGRAPHY OF PRESENTATIONS IS NOT ALLOWED. **2

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OTHER CONSIDERATIONS
As a courtesy to all meeting attendees, please note the following:・ Please make sure all cell phones are turned off when sessions are in progress.
・ Photography is prohibited in all sessions. Your cooperation is greatly appreciated.
PARKING
Please park your car at the parking of The Westin Hotel and take a parking ticket to the front
desk of the hotel. Participants can park cars for free.
CHILD CARE
Due to the professional nature of this meeting, children are not allowed in session, so pleaseplan accordingly. Child care arrangements should be made in advance.
EMERGENCIES
Please notify Awaji Yumebutai International Conference Center staff or The Westin Hotel staff
for basic medical assistance.
ELECTRICITY
Appliances in Japan run on 100V A.C. and plug in to a 2-flat pin, Type A socket. It is difficult tofind sockets compatible with 3-pin plugs or supplying 120V, 200V, and 220V electricity, so werecommend you to bring an adapter with you.
CURRENCY EXCHANGE
Money exchange is possible at the hotel front.
LOCAL TAXESJapan has a sales tax rate of 8% on consumer goods and services.
TIME ZONE
Japan is on Japan Standard Time (JST) or UTC +9 hours.
LIABILITY
The Symposium organizers cannot accept liability for injuries or losses arising from accidents
or other situations during or as a consequence of the Symposium.

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FLOOR MAP

BREAKFAST

Breakfast is included with your accommodation and will be served at the Westin Hotel, 2F,
restaurant ‘COCCOLARE’ with your meal ticket.

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WELCOME RECEPTION
We will throw a Welcome Reception at the Westin hotel, 1F, Banquet Room ‘STELLA’ on
Tuesday, 10 July starting at 18:30.

SMOKING
Both Awaji Yumebutai International Conference Center and The Westin Hotel are smoke-freefacilities except for smoking areas and permitted guest rooms.

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ACCESSBy Public Transportation

Bus154560
451900

8Bus156

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BUS TIMETABLE

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SYMPOSIUM TIMETABLE

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SYMPOSIUM SCHEDULE
July, 1012:30 – 12:45 Opening remarks（Mitsuru Matsumoto, Hiroyuki Kishi）

12:45 – 13:45 Keynote lecture 1（Chair：Mitsuru Matsumoto, Yasunobu Yoshikai）
Kenneth Murphy (Washington University School of Medicine in St. Louis): Development, Help and Cross-presentation by Dendritic cells
13:45 – 14:00 Break
14:00 – 15:00 Session 1（Chair：Hiroyuki Kishi）
Mitsuru Matsumoto（Tokushima University）：Immune tolerance mediated by Aire
Yasunobu Yoshikai (Kyushu University)：Host defense by gamma delta T cells recapitulates their thymic ontogeny
Ichiro Taniuchi (RIKEN)：Regulation of dendritic cell development by Runx factors
15:00 – 15:15 Break15:15 – 16:15 Session 2（Chair：Mitsuru Matsumoto）
Keiko Udaka (Kochi University)：How do tumor-specific Th cells find their way into tumor tissues?
Yasuharu Nishimura (Kumamoto University): Invigoration of tumor immunity by a combined blockade of IL-6- and PD1-mediatedsignals
Shohei Hori (The University of Tokyo)：Transcriptional control of tissue Treg cells
16:15 – 16:30 Break
16:30 – 17:50 Session 3（Chair： Keiko Udaka）
Tadashi Yokosuka (Tokyo Medical University)：Advantages of single molecule imaging for neo-selfTadahiro Suenaga (Osaka University)：Misfolded proteins as the neo-self targets of autoantibodies
Hiroyuki Kishi (University of Toyama)：Toward the repertoire analysis of neo-self recognizing receptors
Hiroshi Kawamoto (Kyoto University)：Regeneration of antigen-specific T cells using the iPS cell technology
17:50 – 18:30 Hotel Check-in（Foyer of Reception Hall B）

18:30 – 20:30 Welcome Reception (Banquet Room ‘STELLA’ on the 1st Floor of the hotel)

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July, 119:00 – 10:00
Keynote lecture 2（Chair： Takehiko Sasazuki, Shigeyuki Yokoyama）
Jamie Rossjohn (Monash University): Immune sensing of vitamin B metabolites
10:00 – 10:15 Break
10:15 – 11:15 Session 4（Chair： Tadashi Yokosuka）
Takehiko Sasazuki (Kyushu University)：HLA controls clinical conversion from Hashimoto thyroiditis to Graves’ disease.
Shigeyuki Yokoyama (RIKEN)：Structure and function of an HLA-DP5•peptide complex
Kouetsu Ogasawara (Tohoku University)：Identification of the pathogenic T cells in metal allergy
11:15 – 11:30 Break
11:30 – 12:30 Session 5（Chair： Koetsu Ogasawara）
Takashi Shiina (Tokai University)：Reference grade characterization of polymorphisms in full-length HLA genes
Kazuyoshi Hosomichi (Kanazawa University)：Landscape of the human MHC via NGS technologies
Hisashi Arase (Osaka University)：Immune evasion by pathogens via MHC class I recognizing inhibitory receptors
12:30 – 12:40 Closing remarks（Yasunobu Yoshikai）

12:40 – 13:00 Commemorative Photo10