㨇කቇ♽⎇ⓥ⑼ౣ↢ක⑼ቇኾ᡹㨉
1. ᢎ⢒࡮⎇ⓥߩℂᔨ㧘⋡ᮡࡅ࠻ోㆮવሶߩႮၮ㈩೉ߩ⸃⺒߇⚳ੌߒߚ 21 ਎♿ߦ߅ߌࠆකቇ࡮ක≮ߩਛᔃ⺖㗴ߩ৻ߟߪ㧘㑆㆑޿ߥߊౣ↢කቇ࡮ක≮ߢ޽ࠆ‫ޕ‬2006 ᐕ 8 ᦬ߦࡑ࠙ࠬ߆ࠄ㧘2007 ᐕ 11 ᦬ߦߪࡅ࠻߆ࠄ㧘ฃ♖ෆࠍ૶ࠊߕߦ૕⚦⢩߆ࠄಽൻᄙ⢻ᕈࠍᜬߟ⚦⢩㧔iPS ⚦⢩㧕߇᮸┙ߐࠇ㧘ߎߩ㗔ၞߦᄢ߈ߥㅴᱠ߇⷗ࠄࠇߚ‫ޕ‬ౣ↢ක⑼ቇኾ᡹ߪකቇ㧘↢๮࡮ᖱႎᎿቇਗ߮ߦ↢๮୶ℂቇߣߩ࡙࠾࡯ࠢߥㅪ៤ߩਅ㧘⚦⢩↢‛ቇ࡮ಽሶㆮવකᎿቇ⊛ቇ໧૕♽ߦട߃㧘ߎࠇࠍ⥃ᐥߦᔕ↪ߔࠆߚ߼ߩౣ↢Ꮏቇ࡮ౣ↢ᔕ↪࡮୶ℂቇߩቇ໧૕♽߆ࠄߥࠆ‫ޕ‬කቇㇱ㧘Ꮏቇㇱ╬ߩ಴り⠪ߦవ┵⊛ౣ↢ක⑼ቇߩ⎇ⓥߣ࡙࠾࡯ࠢߥࠗࡦ࠲࡯ࡀ࠶࠻ᄢ
ቇ㒮ᢎ⢒ New Research Oriented Bidirectional Education Linkage(NOBEL) ࠍⴕ޿㧘ಽሶ↢‛ቇ㧘ක↪↢๮࡮ᖱႎᎿቇ㧘⥃ᐥකቇ߅ࠃ߮␠ળකቇߩฦಽ㊁ߢౣ↢ක⑼ቇࠍਛᔃ⊛ߦᜂ߁ߎߣߩߢ߈ࠆ⍮⊛ഃㅧᕈ࡮ኾ㐷ᕈߣ౒ߦ୶ℂᕈ࡮ੱ㑆ᕈ࡮␠ળᕈߩ⼾߆ߥੱ᧚ࠍ⢒ᚑߔࠆߎߣࠍ⋡ᮡߣߒߡ޿ࠆ‫ޕ‬

2. ౣ↢ක⑼ቇኾ᡹ߩ᭴ᚑ
↢‛ቇ⊛ౣ↢ක⑼ቇࠍ⋡ᜰߔ⁛┙ኾ᡹♽ౣ↢ක⑼ቇߦߪ␠ળ⊛࠾࡯࠭㧘ᧄቇߩታ❣ߣ⃻⁁ࠍ⠨ᘦߒ
ߡ 3 ߟߩ㗔ၞ߆ࠄߥࠆ⚵❱ࠍ⟎޿ߡ޿ࠆ‫ߜࠊߥߔޕ‬㧘ಽሶ↢‛ቇ㧘⊒↢ቇ㧘ㆮવሶᎿቇࠍࡌ࡯ࠬߣߒ
ߚౣ↢ಽሶ⛔ᓮቇ㧘ᦨᣂߩ↢๮Ꮏቇ࡮ᖱႎᎿቇࠍࡌ࡯ࠬߣߒߚౣ↢Ꮏቇ෸߮ߎࠇࠄࠍࡌ࡯ࠬߣߒߚ⥃ᐥᔕ↪ߣߘࠇߦ઻߁୶ℂ⊛໧㗴ࠍᛒ߁ౣ↢ᔕ↪࡮୶ℂቇߢ޽ࠆ‫ߢߎߘޕ‬㧘ᧄኾ᡹ߪ㧘એਅߩ 3 ߟߩ⻠ᐳߢ᭴ᚑߒ㧘㜞ᐲߩ⎇ⓥ⢻ജ߇޽ࠆ⎇ⓥ⠪ࠍಽ㊁೎ߦ 1 ߟߩ᦭ᯏ⊛⛔৻૕ߣߥࠆࠃ߁⚵❱ߒߡ޿ࠆ‫ޕ‬
㧔1㧕ౣ↢ಽሶ⛔ᓮቇ⻠ᐳౣ↢ಽሶ⛔ᓮቇ⻠ᐳߪ㧟ߟߩᢎ⢒⎇ⓥಽ㊁߆ࠄߥࠆ‫ޕ‬ᐙ⚦⢩߆ࠄ⚵❱࡮ེቭᒻᚑߩಽሶ೙ᓮࠍᜂᒰ
ߔࠆ⚵❱࡮ེቭᒻᚑಽ㊁㧘ᧄቇߦ߅ߌࠆ෻኿⎇ⓥᣉ⸳ߩવ⛔ࠍ〯߹߃ߚ␹⚻♽ߩౣ↢ࠍᜂᒰߔࠆ␹⚻↢‛ಽ㊁㧘ౣ↢ߦ߅ߌࠆᓸ↢‛ߩᓎഀࠍᜂᒰߔࠆ∛ේ૕೙ᓮቇಽ㊁ߢ޽ࠆ‫ߦࠄߐޕ‬㧘⚵❱࡮ེቭᒻᚑ
ಽ㊁ߦߪ㧘ߘߩ㊀ⷐᕈࠍ⠨ᘦߒߡㅪ៤⻠ᐳߣߒߡጟፒ࿖┙౒ห⎇ⓥᯏ᭴ၮ␆↢‛ቇ⎇ⓥᚲ⊒↢↢‛ቇ⎇ⓥ♽߇ෳടߒߡ޿ࠆ‫ޕ‬
㧔2㧕ౣ↢Ꮏቇ⻠ᐳౣ↢Ꮏቇ⻠ᐳߪ㧘㧞ߟߩᢎ⢒⎇ⓥಽ㊁߆ࠄߥࠆ‫ޕ‬ㆮવሶ࡮࠲ࡦࡄࠢߩಽሶ᭴ㅧ⸃ᨆߣ㧘ߘࠇߦၮߠ
ߊౣ↢ක≮ߦഃ⮎߿ಽሶࡊࡠ࡯ࡉߩ㐿⊒࡮ᔕ↪ࠍᜂᒰߔࠆ↢๮ᯏ⢻ಽሶ⸳⸘ಽ㊁ߣ㧘⚦⢩߆ࠄ⚵❱࡮ེቭ߇ᒻᚑߐࠇࠆࡊࡠ࠮ࠬߩ㧟ᰴర᭴▽ࠦࡦࡇࡘ࡯࠲ߦࠃࠆࠗࡔ࡯ࠫൻࠍਥߦਛᨔ␹⚻♽ߢᜂᒰߔࠆ⍮⢻ࠗࡔ࡯ࠫᖱႎಽ㊁ߢ޽ࠆ‫ޕ‬
㧔3㧕ౣ↢ᔕ↪ቇ⻠ᐳౣ↢ᔕ↪ቇ⻠ᐳߪ㧘3 ߟߩᢎ⢒⎇ⓥಽ㊁߆ࠄߥࠆ‫ޕ‬ਥߦᓴⅣེ࡮๭ๆེ♽ߩౣ↢ක≮ࠍᜂᒰߔࠆᓴ
Ⅳ∛ᘒቇߣ๭ๆ∛ᘒቇ㧘ߥࠄ߮ߦකቇ♽୶ℂ࡮␠ળකቇߢ޽ࠆ‫ޕ‬ߎࠇࠄߩ⚵❱ߪ㧘නߦਗ೉ߔࠆ⎬⋥ൻߒߚ⚵❱ߢߪߥߊ㧘ᖚ⠪ਗ߮ߦቇ↢㧘ડᬺࠍ฽߻␠ળ⊛࠾࡯࠭ߦᔕ߃ࠆᣂߒ޿ౣ↢ක≮ߩᢎ⢒࡮⎇ⓥࠍ⋡ᜰߒߚ 1 ߟߩ᦭ᯏ⊛⛔৻૕ߣߒߡ⚵❱ߐࠇߡ޿ࠆ‫ࠇߎޕ‬ߦࠃࠅ㧘⎇ⓥࠍࠝ࡯ࡊࡦߦߔࠆߎߣ߇ߢ߈㧘⎇ⓥ⠪㑆ߩ⋧੕࠴ࠚ࠶ࠢ૕೙ࠍᢛ߃㧘⎇ⓥߩ࡟ࡌ࡞ࠕ࠶
ࡊࠍ࿑ࠆ߽ߩߢ޽ࠆ‫ߚ߹ޕ‬㧘ᄢቇ㒮↢ߪ⥄ಽߩ⎇ⓥ߫߆ࠅߢߪߥߊ㧘᭽‫⎇ߩ࠻ࠢࠚࠫࡠࡊߥޘ‬ⓥߦធ
⸅ߔࠆߎߣ߇ߢ߈㧘୶ℂࠍ฽߼ߚᐢ޿ⷞ㊁ߣ⁛ഃ⊛ߥᕁ⠨ㆊ⒟ࠍᜬߟක⑼ቇ⎇ⓥ⠪ࠍ㙃ᚑߔࠆߎߣ߇
น⢻ߣߥࠆ‫ޕ‬㧙㧙

3. ቇ↢ቯຬߣ౉ቇ⁁ᴫౣ↢ක⑼ቇኾ᡹ߩ౉ቇቯຬ㧘෼ኈቯຬ෸߮ㆊ෰㧡ᐕ㑆ߩ౉ቇ⁁ᴫߪᰴ⴫ߩߣ߅ࠅߢ޽ࠆ‫ޕ‬೨ᦼ⺖⒟࡮
ᓟᦼ⺖⒟ߣ߽ߦ౉ቇቯຬࠍߪࠆ߆ߦ⿥߃ߚᔒ㗿⠪߇޽ࠆ‫ߚ߹ޕ‬㧘౉ቇ⠪ߪ౉ቇቯຬߩ⚂ 1.5 ୚ߢ޽ࠅ㧘߈ࠊ߼ߡ㗅⺞ߦផ⒖ߒߡ޿ࠆ‫ޕ‬ౣ↢ක⑼ቇኾ᡹ߩቇ↢ቯຬ෸߮෼ኈቯຬ⎇ⓥ⑼ኾ᡹කቇ♽⎇ⓥ⑼ౣ↢ක⑼ቇኾ᡹

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4. ࠞ࡝ࠠࡘ࡜ࡓߩ✬ᚑᣇ㊎ᧄኾ᡹ߪ㧘↢๮୶ℂ࡮කቇਗ߮ߦ↢๮࡮ᖱႎᎿቇਔಽ㊁߇Ⲣวߒߚᣂߚߥⷞὐ߆ࠄߩౣ↢ක⑼ቇߦ
㑐ߔࠆ໧㗴⸃᳿ဳ⢻േᢎ⢒ࠍⴕ޿㧘㜞ㆳߥ↢๮୶ℂ࡮␠ળᕈ㧘ౣ↢ක⑼ቇ࡮ක≮ߩ⊒ዷߦ⽸₂ߔࠆ್ᢿജ㧘ታⴕജ෸߮⁛ഃᕈߦን߻ੱ㑆ᕈ⼾߆ߥ⎇ⓥ⠪㧔ඳ჻ᓟᦼ⺖⒟㧕ਗ߮ߦ㜞ᐲኾ㐷⡯ᬺੱ㧔೨ᦼ⺖⒟㧘ᓟᦼ⺖⒟㧕ࠍ⢒ᚑߔࠆߎߣࠍ⋡ᮡߣߒߡᢎ⢒⺖⒟ࠍ✬ᚑߒߡ޿ࠆ‫ޕ‬ߎߩࠞ࡝ࠠࡘ࡜ࡓ✬ᚑᣇ㊎ߦၮߠ߈㧘↢๮୶ℂ࡮ౣ↢ක≮ߩၮᧄ⊛ᢎ㙃ࠍりߦઃߌ㧘߆ߟ㧘ౣ↢කቇߩၮ␆࡮⥃ᐥਗ߮ߦౣ↢Ꮏቇߦߟ޿ߡߩᦨవ┵ߩᛛⴚࠍ᦭ߒ㧘ᣂߚߥౣ↢ක⑼ቇࠍవ㚟⊛ߦขࠅ⚵߻⢻ജࠍ᦭ߔࠆ⎇ⓥ⠪࡮㜞ᐲኾ㐷⡯ᬺੱࠍ⢒ᚑߔࠆ‫ޕ‬
㧔1㧕ጁୃၮḰԘඳ჻೨ᦼ⺖⒟2 ᐕ㑆ߩ㑆ߦว⸘ 30 න૏એ਄ࠍୃᓧߒቇ૏⺰ᢥክᩏߦวᩰߒߥߌࠇ߫ߥࠄߥ޿‫ߒߛߚޕ‬㧘․ߦఝࠇ
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ਈߔࠆߎߣ߇޽ࠆ‫ޕ‬⑼‫ޓ⋡ޓ‬඙‫ޓ‬ಽᦨૐጁୃන૏ᢙ

౒‫ޓ‬ㅢ‫⋡ޓ⑼ޓ‬㧢ቇ‫ޓ‬㓙‫⋡ޓ⑼ޓ‬㧞ኾ‫ޓ‬㐷‫⋡ޓ⑼ޓ‬㧝㧠․‫ޓ‬೎‫ޓ⎇ޓ‬ⓥ㧤ว‫⸘ޓޓޓ‬㧟㧜஻‫ޓ‬⠨㧔ᵈ㧕තᬺߒߚቇㇱߦࠃࠅጁୃᣇᴺ߇⇣ߥࠆ‫ޕ‬
ኾ᡹ಽ㊁߆ࠄᔅୃ⑼⋡ 10 න૏ࠍ฽߼㧘14 න૏એ਄ᵈ㧕㧝㧚කቇ෶ߪᱤቇࠍጁୃߔࠆ⺖⒟ࠍතᬺߒߚ⠪ߪ㧘౒ㅢ⑼⋡ߩጁୃන૏ߦ↢๮Ꮏቇ෸߮ᖱႎᎿቇ
ߩ㧞න૏ࠍጁୃߒߥߌࠇ߫ߥࠄߥ޿‫ޕ‬㧙㧙㧞㧚೨㗄ߦ⹥ᒰߔࠆ⠪એᄖߩ⠪ߪ㧘౒ㅢ⑼⋡ߩጁୃන૏ߦ↢๮Ꮏቇ෶ߪᖱႎᎿቇߩ޿ߕࠇ߆㧝න૏ࠍ฽߼ߥߌࠇ߫ߥࠄߥ޿‫ޕ‬ԙඳ჻ᓟᦼ⺖⒟3 ᐕ㑆ߦᦨૐ㒢 10 න૏ࠍขᓧߒߥߌࠇ߫ߥࠄߥ޿‫ߒߛߚޕ‬㧘․ߦఝࠇߚ⎇ⓥᬺ❣ࠍ਄ߍߚ⠪ߪ㧘2ᐕએ਄࿷☋ߒᚲቯߩⷐઙࠍḩߚߒߚ႐ว㧘3 ᐕᧂḩߢ߽ቇ૏ࠍ᝼ਈߔࠆߎߣ߇޽ࠆ‫ޕ‬⑼‫ޓ⋡ޓ‬඙‫ޓ‬ಽᦨૐጁୃන૏ᢙ

౒‫ޓ‬ㅢ‫⋡ޓ⑼ޓ‬㧞㧔ᵈ㧕තᬺߒߚቇㇱߦࠃࠅጁୃᣇᴺ߇⇣ߥࠆ‫ޕ‬ቇ‫ޓ‬㓙‫⋡ޓ⑼ޓ‬㧞㧔ᵈ㧕තᬺߒߚቇㇱߦࠃࠅጁୃᣇᴺ߇⇣ߥࠆ‫ޕ‬
ኾ᡹ಽ㊁߆ࠄᔅୃ⑼⋡ 10 න૏ࠍ฽߼㧘14 න૏એ਄ኾ‫ޓ‬㐷‫⋡ޓ⑼ޓ‬㧞․‫ޓ‬೎‫ޓ⎇ޓ‬ⓥ㧠ว‫⸘ޓޓޓ‬

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஻‫ޓ‬⠨

ᵈ㧕
㧝㧚කቇ෶ߪᱤቇࠍጁୃߔࠆ⺖⒟ࠍතᬺߒߚ⠪ߪ㧘౒ㅢ⑼⋡ߩ↢๮Ꮏቇ෶ߪᖱႎᎿቇࠍ฽߼ߥߌ
ࠇ߫ߥࠄߥ޿‫ޕ‬㧞㧚೨㗄ߦ⹥ᒰߔࠆ⠪એᄖߩ߽ߩߪ㧘౒ㅢ⑼⋡ߩಽሶ↢‛⑼ቇ෶ߪ᭴ㅧ∛ᘒකቇࠍ฽߼ߥߌࠇ߫
ߥࠄߥ޿‫ޕ‬㧟㧚ౣ↢ක⑼ቇኾ᡹ඳ჻೨ᦼ⺖⒟߆ࠄㅴቇߒߚ⠪ߪ㧘౒ㅢ⑼⋡෸߮ቇ㓙⑼⋡ߩጁୃࠍ఺㒰ߔࠆ‫ޕ‬
㧔2㧕ᢎ⢒⎇ⓥಽ㊁㧘ᜰዉᢎຬౣ↢ක⑼ቇኾ᡹ߦ߅ߌࠆฦ㗔ၞ೎ߩᢎ⢒⎇ⓥಽ㊁㧘ᜰዉᢎຬ㧘ਥߥ⎇ⓥౝኈߪᰴߩ⴫ߩߣ߅ࠅߢ޽ࠆ‫ޕ‬٤ౣ↢ಽሶ⛔ᓮቇ㗔ၞ㧔⻠ᐳ㧕ಽ‫ޓޓޓ‬㊁⚵❱࡮ེቭᒻᚑ

␹⚻↢‛∛ේ૕೙ᓮቇ

ᜰዉᢎຬ⎇‫ޓޓޓ‬ⓥ‫ޓޓޓ‬ౝ‫ޓޓޓ‬ኈ࿡⽵㓉ᒄ⢦ᕈᐙ⚦⢩㧔ES ⚦⢩㧘iPS ⚦⢩㧕ࠍ฽߻ᐙ⚦⢩߆ࠄ⚵❱࡮ེቭᒻᚑߦ⥋ࠆ⚦⢩ߩჇᱺ࡮ಽൻߩࡔࠞ࠾࠭ࡓߦߟ޿ߡ㧘⚦⢩↢‛ቇ⊛ᚻᴺߣಽሶ↢‛ቇ⊛ᚻᴺࠍ↪޿ߡ⎇ⓥࠍⴕ߁‫․ޕ‬ቯߩ⚦⢩࡮⚵❱࡮⤳ེߦߣࠄࠊࠇࠆߎߣߥߊ㧘ᐙ⚦⢩߆ࠄߩ⚵❱࡮⤳ེߩᒻᚑㆊ⒟ߣᐙ⚦⢩⥄りߩಽൻ࡮Ⴧᱺ࡮⥄Ꮖౣ↢ᯏ᭴ߩ⸃ᨆ
ࠍㅢߒߡ㧘ౣ↢⃻⽎ߩಽሶ೙ᓮᯏ᭴ߩᦨ⚳⊛ߥ⸃᣿ߦะߌߡᢎ
⢒࡮⎇ⓥࠍⴕ߁‫ ࠻ࡅޕ‬ES ⚦⢩࡮iPS ⚦⢩߆ࠄ⚵❱࡮⤳ེࠍ⺃ዉߒౣ↢ක≮߳ㆡ↪ߔࠆ⎇ⓥ߽ㅴ߼ߡ޿ࠆ‫ޕ‬ਛᎹᢅᐘ␹⚻⑼ቇ㗔ၞߦ߅޿ߡ㧘␹⚻ᐙ⚦⢩ߩჇᱺ࡮ಽൻ⺃ዉ࡮ࠕࡐ࠻࡯ࠪࠬ㧔ᄌᕈ㧕ᯏ᭴ߩ⸃᣿ߪ␹⚻∔ᖚߩᴦ≮ᴺߩ㐿⊒ߦߣࠅ㊀ⷐߥ⺖㗴ߢ޽ࠆ‫‛↢⚻␹ޕ‬ಽ㊁ߢߪ␹⚻ᄌᕈ㧔ࠕࡐ࠻࡯ࠪࠬ㧕ߩಽሶ೙ᓮᯏ᭴ߦ㑐ਈߔࠆㆮવሶ⟲ࠍ✂⟜⊛ߦหቯߔࠆᣇᴺࠍ
⏕┙ߒ㧘␹⚻ᄌᕈ㑐ㅪㆮવሶߩ⚦⢩߆ࠄ࿕૕࡟ࡌ࡞ߢߩ૞↪ᯏ᭴ߦߟ߈㧘ಽሶ↢‛ቇ㧘⚦⢩↢‛ቇ㧘෸߮ࡑ࠙ࠬㆮવቇࠍ㚟૶ߒߚ⎇ⓥࠍⴕ߁‫ߦࠄߐޕ‬㧘ࠕ࡞࠷ࡂࠗࡑ࡯∛ߦઍ⴫ߐࠇࠆ␹⚻ᄌᕈ∔ᖚߩ∛ᘒߩ⸃᣿ߦߟ޿ߡ߽ขࠅ⚵߻‫ޕ‬ᳯፒቁⴕ∔∛෸߮㜞㦂ൻߦࠃࠅ఺∉♽߇⎕უߐࠇߡ޿ߊਛߢ㧘1,000 ⒳㘃ࠍ⿧ߔᓸ↢‛∛ේ૕ߦኻߔࠆ୘‫ߩޘ‬ኋਥߩᛶ᛫ᕈߩ࡟ࡌ࡞ࠍ
੍᷹ߒቯ㊂ൻߔࠆᣇᴺࠍ⎇ⓥ㐿⊒ߔࠆ‫ࠅࠃߦࠇߎޕ‬㜞ᐲߩ⤳ེౣ↢ක≮߇ታⴕߐࠇࠆ႐วߦㆣㆄߔࠆᗵᨴࠍ੍᷹ߒ㧘ᓸ↢‛ࠍ૶↪ߒߚ୘‫ߩޘ‬୘૕⁛⥄ߩᗵᨴᛶ᛫ᕈߩౣ↢ࠍⴕ߁ᴦ≮ᴺߩ⏕┙ࠍ⋡ᜰߔ‫ޕ‬㧙㧙٤ౣ↢Ꮏቇ㗔ၞ㧔⻠ᐳ㧕ಽ‫ޓޓޓ‬㊁⍮⢻ࠗࡔ࡯ࠫᖱႎ

ᜰዉᢎຬ⎇‫ޓޓޓ‬ⓥ‫ޓޓޓ‬ౝ‫ޓޓޓ‬ኈ⮮↰ᑝᔒࠦࡦࡇࡘ࡯࠲ࠍ㚟૶ߒߡ㧘ක↪↹௝ᖱႎࠍ޿ࠈ޿ࠈߥⷺᐲ߆ࠄ
ಣℂ࡮ടᎿߒ㧘ౣ↢ක⑼ቇࠍߪߓ߼᭽‫ߥޘ‬ක≮ಽ㊁ߦ߅ߌࠆ↹௝ᖱႎࠍขࠅᛒߞߚᢎ⢒࡮⎇ⓥࠍⴕ߁‫߫߃଀ޕ‬㧘ࠦࡦࡇࡘ࡯࠲ᡰេ
⸻ᢿ㧔CAD㧕ߣ๭߫ࠇߡ޿ࠆ߇㧘↹௝਄ߩ߇ࠎ∛ᄌߩ૏⟎ࠍࠦࡦࡇࡘ࡯࠲ߢᜰ៰ߒߚࠅ㧘∛ᄌㇱ૏ߩࠦࡦࡇࡘ࡯࠲ಽᨆߦࠃࠆ⚿ᨐࠍකᏧߦឭଏߔࠆߎߣߦࠃߞߡ㧘ࠃࠅᱜ⏕ߢ⏕ታߥකᏧߩ↹௝⸻ᢿ߇ⴕ߃ࠆࠃ߁ߦᡰេߔࠆࠪࠬ࠹ࡓߩ㐿⊒ߢ޽ࠆ‫↹ޕ‬௝ᖱႎಣℂᛛⴚ㧘ࡃ࡯࠴ࡖ࡞࡝ࠕ࡝࠹ࠖ㧔VR㧘઒ᗐ⃻ታ㧕㧘ੱᎿ⍮⢻ߥߤߩᦨవ┵ߩක≮↹௝ᖱႎቇߦ㑐ߔࠆၮ␆⎇ⓥࠍⴕ޿㧘߹ߚ㧘කᎿቇ
ಽ㊁ߩฦ⒳ߩቇ㓙㗔ၞߩ↹௝⎇ⓥߦᔕ↪ߔࠆ‫ޕ‬٤ౣ↢ᔕ↪ቇ㗔ၞ㧔⻠ᐳ㧕ಽ‫ޓޓޓ‬㊁

ᓴⅣ∛ᘒቇ

๭ๆ∛ᘒቇ

කቇ♽୶ℂ࡮␠ળකቇ

ᜰዉᢎຬ⎇‫ޓޓޓ‬ⓥ‫ޓޓޓ‬ౝ‫ޓޓޓ‬ኈḊญା਽ੱ࡮േ‛࡮ᬀ‛࡮㝼੺㘃ߩ∛ේᓸ↢‛ߩขࠅᛒ޿ࠍ⠌ᾫߐߖ㧘ߎࠇࠄߩᗵᨴ∝ࠍ੍㒐೙ᓮߔࠆᣇᴺ⺰ࠍୃᓧߐߖࠆ‫ࠗࡃߦ․ޕ‬ࠝ࠹ࡠኻ╷㧘㜞㦂ൻ␠ળߩᣣ๺⷗ᗵᨴ∝ࠍ೙ᓮߔࠆਔᭂ┵ߩᗵ
ᨴ೙ᓮᣇᴺࠍ⠌ᓧߐߖ㧘ᗵᨴ೙ᓮߩᜰዉ㧘⎇ⓥᜰዉ߇ߢ߈ࠆੱ
᧚ࠍ⢒ᚑߔࠆ‫ޕ‬Ḋญା਽ᄖ⇇ߣធߒߡ޿ࠆ๭ๆེ♽ߪ⒳‫∛ߩޘ‬ේ૕߿᦭ኂ‛⾰ߦߐࠄߐࠇ㧘ߘࠇߦࠃࠅᄙߊߩ᳇㆏߿⢖⢩ߩ்ኂࠍ↢ߓࠆ‫∉఺ߚ߹ޕ‬ᯏ᭴ߩ⊒㆐ߒߡ޿ࠆ๭ๆེ♽ߪ㧘૕ౝ߿ᄖ⇇߆ࠄߩ⒳‫ߩޘ‬ೝỗߦࠃࠆ఺∉ᔕ╵ߩ⇣Ᏹߦࠃࠆ்ኂ߽↢ߓࠆ‫ޕ‬৻ᣇ㧘்ኂᓟߩୃᓳߩࡊࡠ࠮ࠬߪಽൻ㧘Ⴧᱺ㧘ࠕࡐ࠻࡯ࠪࠬ
ߩࡊࡠ࠮ࠬߦࠃࠅౣ↢ߐࠇࠆ‫்ޕ‬ኂߦࠃࠅ↢ߓࠆ๭ๆེ♽ߩઍ⴫⊛∔ᖚߣߒߡ᳇㆏਄⊹ߩ்ኂࠍ᧪ߔᘟᕈ᳇▤ᡰἻ㧘⢖⢩்ኂࠍ᧪ߔ⢖᳇⣲㧘⚦⢩ߩㆮવሶᄌ⇣ࠍ᧪ߔ⢖߇ࠎ㧘఺∉ᯏ᭴ߩ⇣Ᏹ߆ࠄ↢ߓࠆ᳇▤ᡰ༎ᕷ߿㑆⾰ᕈ⢖Ἳ߇޽ࠆ‫்ࠄࠇߎޕ‬ኂࠍฃߌߚ๭ๆེ♽ߩ⚦⢩߿⚵❱ࠍ repair ߔࠆߚ߼ౣ↢කቇߔߥࠊߜ
∛⊛⚵❱㧘ེቭߩୃᓳߩߚ߼ᐙ⚦⢩⺃ዉ㧘⒖ᬀ㧘⚵❱㧘ེቭߩ⒖ᬀ㧘ಽൻ㧘Ⴧᱺ㧘ࠕࡐ࠻࡯ࠪࠬ⺃ዉࠍ⋥ធⴕ߁ߎߣ߿ㆮવሶ
ᴦ≮ߦࠃࠅౣ↢ࠍⴕ߁‫ޕ‬ၭ㙃♽ߣߒߡ᳇㆏਄⊹߿⢖⢩਄⊹⚦⢩ࠍ↪޿ߚၭ㙃ታ㛎♽㧘േ‛ࡕ࠺࡞ߣߒߡ⢖᳇⣲㧘⢖✢⛽∝㧘⢖߇ࠎ㧘᳇▤ᡰ༎ᕷࡕ࠺
࡞ࠍ↪޿ߚታ㛎♽ਗ߮ߦࡅ࠻ߩ∔ᖚࠍኻ⽎ߣߒߚ⎇ⓥࠍవ┵⊛⥃ᐥᔕ↪ࠍ⋡ᜰߒߡᢎ⢒ߣ⎇ⓥࠍⴕ߁‫ޕ‬Ⴆ↰ᢘ⟵

1978 ᐕߦ‫⑼⊖ࠬࠢ࠶ࠪࠛࠝࠗࡃޟ‬੐ౖ‫߇ޠ‬಴ ߐࠇߡ߅ࠅ㧘ߘߩ㗃ߦ‫↢ޟ‬๮୶ℂቇ‫߇ޠ‬ᚑ┙ߒߚߣ޿ࠊࠇߡ޿ࠆ‫ࠅࠃߣ߽ޕ‬කߩ୶ℂቇߪ㧘቟ᭉᱫ㧘⣖ᱫ࡮⤳ེ⒖ᬀ㧘ੱᎿᅧᆼਛ⛘ߥߤ㧘ᓥ᧪ߩක≮ⴕὑߩਛߢߪ⑌ᱛߐࠇߡ޿ߚⴕὑߩ⸵ኈၮḰࠍ᣿ࠄ߆ߦߔࠆ⋡⊛ߢ㓸⚂ߐࠇߡ߈ߚߣ⸃ߐࠇࠆ‫߇ࠈߎߣޕ‬㧘ᤓ੹ࠢࡠ࡯
ࡦ୘૕໧㗴߇ᶋ਄ߒ㧘↢๮୶ℂߩ㊀ᔃ߇୘ੱߩ⥄Ꮖ᳿ቯ߆ࠄ౏
౒ㆬᛯߦ⒖േߒߡ߈ߡ߅ࠅ㧘ߘߎߦߪࠕࡔ࡝ࠞဳߣ࡛࡯ࡠ࠶ࡄ
ဳߩኻ┙߽ㄭᐕߒߛ޿ߦ᣿ࠄ߆ߦߥߞߡ߈ߡ޿ࠆ‫ޕ‬කቇ࡮ක≮ߩታ㓙ࠍ⍮ࠆ⠪߇㧘ౣ↢ක⑼ቇߦ઻߁ోߡߩ୶ℂ⊛㧘␠ળකቇ⊛ߥ໧㗴ࠍ࠲࡯ࠥ࠶࠻ߣߒߡ㧘ᣣᧄߢߩὼࠆߴ߈↢๮୶ℂࠍ⠨ⓥߔߴߊߘߩᢎ⢒࡮⎇ⓥࠍⴕ߁‫ޕ‬

㧔3㧕ၮ␆ᛛⴚ࠻࡟࡯࠾ࡦࠣࠦ࡯ࠬ
ක⑼ቇኾ᡹ 4 ߩ㧔3㧕ߢ␜ߒߚၮ␆ᛛⴚ࠻࡟࡯࠾ࡦࠣࠦ࡯ࠬࠍⴕߞߡ޿ࠆ‫ޕ‬㧙㧙㧔4㧕ᄢቇ㒮․೎⻠⟵ฦ⻠ᐳߩ⎇ⓥ⊒⴫࡮․೎⻠Ṷ߆ࠄߥࠆవ┵ౣ↢ක⑼ቇ࠮ࡒ࠽࡯ࠍᐕ 6 ࿁㧘ౣ↢ක⑼ቇኾ᡹ߩో⻠ᐳ߇ෳടߒߡⴕߞߡ޿ࠆ‫ߚ߹ޕ‬ᄢቇ㒮․೎⻠⟵ߪ㧘ฦ⻠ᐳࠍਛᔃߦ㓐ᤨታᣉߒߡ޿ࠆ‫ޕ‬

5. ᢎ⢒ᵴേ
㧔1㧕ᢎ⢒ᵴേߩታᣉౝኈߣᣇᴺౣ↢ක⑼ቇኾ᡹߇㐿⻠ߒߡ޿ࠆ⻠⟵⑼⋡ࠍએਅߦ␜ߔ‫ޕ‬Ԙ ඳ჻೨ᦼ⺖⒟᝼‫ޓޓޓޓ‬ᬺ‫⋡ޓޓޓޓ⑼ޓޓޓޓ‬න૏ᢙㆬᛯ࡮ᔅୃߩ೎↢๮Ꮏቇ1ㆬ‫ޓޓ‬ᛯᖱႎᎿቇ1ㆬ‫ޓޓ‬ᛯ

᭴ㅧ↢‛කቇ

1ㆬ‫ޓޓ‬ᛯ

↢‛කቇ୶ℂ1ᔅ‫ୃޓޓ‬↢‛කቇ୶ℂṶ⠌1ᔅ‫ୃޓޓ‬⚵❱࡮ེቭ⊒↢

2

ㆬᛯᔅୃ

␹⚻↢‛ቇ

2

ㆬᛯᔅୃ

∛ේ૕೙ᓮቇ

2ㆬᛯᔅୃㆮવᖱႎഃ⮎

2ㆬᛯᔅୃක↪ᖱႎಣℂ2ㆬᛯᔅୃ⥃ᐥౣ↢කቇ

2ㆬᛯᔅୃකቇ♽୶ℂ࡮␠ળකቇ

2

ㆬᛯᔅୃ

න૏ᢙ

ㆬᛯ࡮ᔅୃߩ೎

౒‫ޓ‬ㅢ‫⋡ޓ⑼ޓ‬ቇ‫ޓ‬㓙‫⋡ޓ⑼ޓ‬ਥߥኾ㐷⑼⋡

ԙඳ჻ᓟᦼ⺖⒟᝼‫ޓޓޓޓ‬ᬺ‫⋡ޓޓޓޓ⑼ޓޓޓޓ‬౒‫ޓ‬ㅢ‫⋡ޓ⑼ޓ‬ቇ‫ޓ‬㓙‫⋡ޓ⑼ޓ‬ኾ‫ޓ‬㐷‫⋡ޓ⑼ޓ‬ၮ␆⥃ᐥౣ↢කቇ1ㆬ‫ޓޓ‬ᛯ

ౣ↢ක≮୶ℂ1ᔅ‫ୃޓޓ‬

ౣ↢ක≮୶ℂṶ⠌1ᔅ‫ୃޓޓ‬

ᐙ⚦⢩⚵❱ᎿቇṶ⠌2ㆬᛯᔅୃಽሶ␹⚻⚦⢩↢‛ቇṶ⠌

2

ㆬᛯᔅୃ

ᓸ↢‛ࡃࠗࠝࠗࡦࡈࠜࡑ࠹ࠖ࠶ࠢࠬṶ⠌

2

ㆬᛯᔅୃ

⍮⢻ࠗࡔ࡯ࠫᖱႎᔕ↪Ṷ⠌

2

ㆬᛯᔅୃ

⚦⢩࡮⚵❱࡮ེቭ⒖ᬀ࡮ㆮવሶᴦ≮Ṷ⠌

2

ㆬᛯᔅୃ

කቇ♽୶ℂṶ⠌2ㆬᛯᔅୃቇ↢ߪ㧘੍߼ᜰዉᢎຬߩᜰ␜ࠍฃߌߡጁୃߔࠆ᝼ᬺ⑼⋡ࠍ᳿ቯߔࠆ‫ߚ߹ޕ‬㧘ᜰዉᢎຬ߇ᔅⷐߣ⹺߼
ࠆᤨߪ㧘ቇㇱߩ᝼ᬺ⑼⋡㧘ઁߩኾ᡹࡮⎇ⓥ⑼╬ߩ᝼ᬺ⑼⋡ࠍጁୃߔࠆߎߣ߇ߢ߈ࠆ‫ޕ‬ቇ↢ߪᜰዉᢎຬ
ߩᜰዉߩਅߢ⎇ⓥ⸘↹ᦠࠍ૞ᚑߩ਄㧘ቇ૏⺰ᢥ૞ᚑߦᔅⷐߥ⎇ⓥᵴേࠍⴕ߁‫ޕ‬ౣ↢ක⑼ቇኾ᡹ߢߪ㧘ᢎቶߢߩ⻠⟵㧘ታ㛎ቶߢߩታ㛎ᜰዉ㧘࠮ࡒ࠽࡯ቶߢߩታ㛎࠺࡯࠲ߩ⸛⺰㧘⺰ᢥߩ⹦⺒ળࠍᲤㅳⴕߞߡ޿ࠆ‫ޕ‬ඳ჻೨ᦼ⺖⒟෸߮ᓟᦼ⺖⒟ߩᢎ⢒ߪ㧘ࠗࡦ࠲࡯ࡀ࠶࠻࡮ࡎ࡯ࡓࡍ࡯ࠫ "NOBEL" ࠍㅢߓߡⴕߞߡ޿
ࠆ‫ޕ‬㐿⻠ᦼ㑆ਛ㧘ฦ⑼⋡ࠍㆬᛯߒߚቇ↢ߪࠗࡦ࠲࡯ࡀ࠶࠻਄ߩࡎ࡯ࡓࡍ࡯ࠫ෸߮ࡔ࡯࡝ࡦࠣ࡝ࠬ࠻ࠍ
ㅢߓߡᢎຬߣᗧ⷗੤឵ࠍⴕ޿㧘ਈ߃ࠄࠇߚ⺖㗴ߦ㑐ߒߡᢎຬ෸߮ቇ↢߇⼏⺰ࠍⓍߺ㊀ߨࠆ‫ୃߩ⋡⑼ޕ‬㧙㧙ੌᤨߦߪ࡟ࡐ࡯࠻ࠍឭ಴ߒ㧘ቇ⠌ᚑᨐࠍ㧘ฦ⑼⋡ࠍㆬᛯߒߚቇ↢ߣᢎຬߦኻߒߡ⻠Ṷߒฦ⑼⋡ࠍୃੌߔࠆ‫ޕ‬1㧕 ೨ᦼ㧦4 ᦬㧙 7 ᦬㧘NOBEL ᴺߦߡࠗࡦ࠲࡯ࡀ࠶࠻਄ߢ⺖㗴ࠍቇ⠌
9 ᦬ߦᦨ⚳࡟ࡐ࡯࠻ឭ಴ߣ⊒⴫⻠Ṷ
2㧕 ᓟᦼ :10 ᦬㧙 1 ᦬㧘NOBEL ᴺߦߡࠗࡦ࠲࡯ࡀ࠶࠻਄ߢ⺖㗴ࠍቇ⠌
2 ᦬ߦᦨ⚳࡟ࡐ࡯࠻ឭ಴ߒ⊒⴫⻠Ṷ߹ߚ㧘ౝᄖߩᄢቇ࡮⎇ⓥᯏ㑐ߣߩ౒ห⎇ⓥਗ߮ߦ⇐ቇ↢੤឵߽Ⓧᭂ⊛ߦ᛼ߒㅴ߼㧘ቇ㓙⊛࡮✚ว⊛⎇ⓥߩផㅴߣߣ߽ߦ࿖㓙⊛ㅢ↪ᕈ࡮౒ㅢᕈߩ⏕଻ߦ߽ജࠍᵈ޿ߢ޿ࠆ‫ޕ‬ߎߩ߶߆㧘ᧄኾ᡹ߩᢎ⢒࡮⎇ⓥᵴേߩ․ᓽߣߒߡએਅߩ߽ߩࠍ᜼ߍࠆߎߣ߇ߢ߈ࠆ‫ޕ‬Ԙ⻠ᐳන૏ߢቇ↢ߩᢎ⢒࡮⎇ⓥᜰዉߦᒰߞߡ޿ࠆ߇㧘ᒰኾ᡹߇ቇ㓙⊛ಽ㊁ߢ޽ࠆߎߣ߽޽ࠅ㧘⻠ᐳߩᨒߦߣࠄࠊࠇߕකቇၮ␆♽࡮⥃ᐥ♽࡮Ꮏቇ♽߇౒หߒߡቇ↢ߩ⎇ⓥᜰዉࠍⴕ߁ߥߤ㧘ᨵエߥᜰዉ૕೙ࠍណ↪
ԙ ᄢቇ㒮⸳⟎ၮḰ╙ 14 ᧦․଀ߩᤤᄛ㐿⻠೙ࠍታᣉԚ↢๮࡮ක≮୶ℂࠍ㊀ⷞߒ㧘೨ᦼ⺖⒟ߢߪ↢‛කቇ୶ℂࠍ㧘ᓟᦼ⺖⒟ߢߪౣ↢ක≮୶ℂߩጁୃࠍᔅୃൻԛ೨ᦼ⺖⒟ߢߪ⚦⢩↢‛ቇ㧘ಽሶ⊒↢ቇ㧘ಽሶ↢‛ቇ╬ߩၮ␆↢๮⑼ቇߩᢎ⢒࡮⎇ⓥࠍ㧘ᓟᦼ⺖⒟ߢߪౣ↢ᔕ↪╬ߩᔕ↪↢๮⑼ቇߩᢎ⢒࡮⎇ⓥࠍታᣉ㧙㧙6㧚 ⎇ⓥᵴേާౣ↢ಽሶ⛔ᓮቇ⻠ᐳި
㧔1㧕⚵❱࡮ེቭᒻᚑಽ㊁1㧚⎇ⓥߩ᭎ⷐ
࿡⽵ߣᧄᯅߪ ES ⚦⢩߆ࠄ⺃ዉߒߚ⚦⢩࡮⚵❱࡮ེቭࠍౣ↢ක≮ߦㆡ↪ߔࠆߚ߼ߩၮ␆⎇ⓥࠍⴕߞߡ޿
ࠆ‫ޕ‬2000 ᐕએ㒠ߦࡑ࠙ࠬ ES ⚦⢩߆ࠄ࡟ࡦ࠭㧘✂⤑⚦⢩ࠍ฽߻⌒᭽᭴ㅧࠍ⺃ዉߔࠆᛛⴚߩ㐿⊒ߦᚑഞߒ㧘ES ⚦⢩߆ࠄ⹜㛎▤ౝߢ⚵❱࡮ེቭࠍ⺃ዉߢ߈ࠆߣ޿߁೨଀ߩߥ޿น⢻ᕈࠍ␜ߒߡએ᧪㧘⌒᭽᭴ㅧߩౣ↢ක≮߳ߩㆡ↪ࠍ߼ߑߒ㧘࠻࡝߿ࡑ࠙ࠬߩ⌒⃿߳⒖ᬀߒ↢⌕ߔࠆߎߣࠍ⏕⹺ߒߚ‫ᦨޕ‬ㄭ㧘ጘ㒂ᄢቇ⣲≌∛ℂߣߩ౒หߢࡅ࠻ ES ⚦⢩߆ࠄ✂⤑᭽᭴ㅧࠍ⺃ዉߔࠆߎߣߦᚑഞߒߚ‫ޕ‬␹⚻ႇ⚦⢩ߪ␹⚻▤߆ࠄ⊒↢ߔࠆᄖ⢦⪲↱᧪ߩ⚦⢩ߢ޽ࠅ㧘㕖Ᏹߦᄙ᭽ߥ⚦⢩㧔⦡⚛⚦⢩㧘ᐔṖ╭㧘㛽࡮エ㛽ߥߤߩ㑆⪲♽⚦⢩㧘␹⚻⚦⢩㧘ࠣ࡝ࠕ⚦⢩ߥߤߩᧃ᪳␹⚻♽⚦⢩㧘ౝಽᴲེቭ᭴ᚑ⚦⢩ߥߤ㧕ߦಽൻჇᱺߔࠆᄙಽൻ⢻ࠍ᦭ߒߡ޿ࠆ‫ޕ‬ᚒ‫ ߪޘ‬ES ⚦⢩߆ࠄߎߩ␹⚻ႇ⚦⢩ࠍ⺃ዉߔࠆߎߣߦᚑഞߒ㧘ߎߩ vitroߩಽൻჇᱺࠍ⹦⚦ߦ⸃ᨆߔࠆߎߣߢ㧘⃻࿷߹ߢߘߩో⽩߇᣿ࠄ߆ߦߐࠇߡ޿ߥ޿␹⚻ႇ⚦⢩ߩ⊒↢෸߮ಽൻߩࡔࠞ࠾࠭ࡓࠍ᣿ࠄ߆ߦߒߟߟ޽ࠆ‫ޕ‬ౣ↢ක≮߳ߩขࠅ⚵ߺߣߒߡ㧘␹⚻ႇ⚦⢩ߩ⇣Ᏹߦࠃߞߡ⊒∝ߔ
ࠆ㊀◊ߥᧃ᪳␹⚻⎕✋ߢ޽ࠆ Hirschsprung disease ߿ Waardenburg Syndrome ߥߤߩ␹⚻ႇ∝ߩ⚦⢩ᴦ≮ߦ⚿߮ߟߌߚ޿ߣ⠨߃ߡ޿ࠆ‫ޕ‬ߎࠇࠄߩ⎇ⓥߩ⥃ᐥᔕ↪ࠍⷞ㊁ߦ౉ࠇ㧘2003 ᐕߦࡅ࠻ ES ⚦⢩ߩ૶↪⸵นࠍฃߌ㧔ᣣᧄߢ 5 ⇟⋡ߩ૶↪ᯏ㑐㧕㧘⃻࿷߹ߢߦᔃ╭㧘ⴊᶧ⚦⢩㧘✂⤑⦡⚛⚦⢩ߥߤߩ⺃ዉߦᚑഞߒߡ޿ࠆ‫ޕ‬
2006ᐕ߆ࠄ㧘ᚻႦࠍਛᔃߦญ⣧∛ᘒቇߣߩ౒หߢⷫ⍮ࠄߕ߆ࠄ㑆⪲♽ᐙ⚦⢩ࠍណขߒ㧘⃻࿷߹ߢߦ⚂200ੱಽߩᱤ⢦ᐙ⚦⢩ࡃࡦࠢࠍ᮸┙ߒߡ޿ࠆ‫⚦ߩࠄࠇߎޕ‬⢩ࠍ↪޿ߡ዁᧪ᱤ߿㛽ߩౣ↢ක≮ࠍⴕ߁ߴߊ㧘
ᢛᒻᄖ⑼ቇߣߩ౒หࠍ฽߻ಽ㊁ᮮᢿ⊛ߥ⎇ⓥࠍㅴ߼ߡ޿ࠆ‫ߦࠢࡦࡃߩઁޕ‬Ყߴ቟ో࡮቟ଔ࡮ല₸⦟ߊ⚦⢩ࡃࡦࠢ߇᭴ᚑߢ߈ࠆ೑ὐࠍ↢߆ߒ㧘਎⇇ߢೋ߼ߡߩታ↪⊛ߥᐙ⚦⢩ࡃࡦࠢߦ⊒ዷߐߖߚ޿‫ޕ‬ญ⣧∛ᘒቇ㧘੩ㇺᄢቇౣ↢කቇ⎇ⓥ࠮ࡦ࠲࡯ߣߩ౒ห⎇ⓥߦࠃࠅࡅ࠻ᱤ⢦ᐙ⚦⢩ߪઁߩࡅ࠻⚦⢩ߦᲧߴߡੱᎿᄙ⢻ᕈᐙ⚦⢩㧔iPS ⚦⢩㧕ߦല₸ࠃߊ⺃ዉߐࠇࠆߎߣࠍ᣿ࠄ߆ߦߒߚ‫ߩߎޕ‬ᚑᨐࠍၮ␆ߦ㧘JST ጊਛ iPS ․೎ࡊࡠࠫࠚࠢ࠻ߩጘ㒂ᄢቇࠨ࠹࡜ࠗ࠻࠴࡯ࡓߣߒߡല₸⊛ߥ iPS ⚦⢩⺃ዉࠍ⋡ᜰߔ⎇ⓥ߇ 2008ᐕᐲࠃࠅ㐿ᆎߐࠇߚ‫ޕ‬ᚻႦߪⶄ㔀♽ࡕ࠺࡞ߩ߭ߣߟߢ޽ࠆ෻ᔕ᜛ᢔ♽ࠍ↪޿ߡ㧘઒ᗐ㛽࡝ࡕ࠺࡝ࡦࠣࡕ࠺࡞‫ޟ‬iBone‫ࠍޠ‬૞⵾ߒ㧘㛽ߦሽ࿷ߔࠆ⚦⢩߇ജቇⅣႺߦㆡᔕߒߚ㛽ᓸ⚦ᒻᘒࠍᒻᚑߔࠆㆊ⒟ࠍࠪࡒࡘ࡟࡯࠻ߒߚ‫⎇ߌ߇߈ߐޕ‬ⓥߥߤߩᄢဳቇᄖ୘ੱ⎇ⓥ⾌ߥߤࠍฃߌ㧘ᧄቇᢛᒻᄖ⑼㧘ญ⣧ᄖ⑼ߩදജࠍᓧߡ㧘ࡅ࠻ᄢ⣽㛽ㄭ૏┵ߩᒻ⁁ߩౣ⃻㧘㗶㛽ߩᒻᚑ࡮ୃᓳㆊ⒟߿㛽☻㝃∝ߩౣ⃻ߦ߽ᚑഞߒߡ޿ࠆ‫ߦࠄߐޕ‬㧘ᄢℂ⍹∛ߩࡕ࠺࡞ࡑ࠙ࠬ
ࠍ↪޿ߡߎߩ∛ᘒߩㅴⴕㆊ⒟ࠍࠪࡒࡘ࡟࡯࠻ߔࠆ⎇ⓥ߽㐿ᆎߒ㧘iBone ߩ᦭ലᕈࠍࠃࠅ⹦⚦ߦᬌ⸽ߒߡ޿
ࠆ‫ᦨޕ‬ㄭ㧘ߎߩࡊࡠࠣ࡜ࡒࡦࠣᛛⴚࠍ iPS ⚦⢩ߩ⺃ዉߦᔅⷐߥ⚦⢩ߩೋᦼൻߩࠪࡒࡘ࡟࡯࡚ࠪࡦߦㆡ↪ߔߴߊ㧘ᣂߚߥዷ㐿߽࿑ߞߡ޿ࠆ‫ޕ‬
2㧚ฬ★
࿡⽵㓉ᒄ
ᢎ᝼㧦
ಎᢎ᝼㧦 ᚻႦᑪ৻
ᧄᯅജ⻠Ꮷ㧦Takahiro Kunisada
Ken-ichi Tezuka
Tsutomu Motohashi

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
1㧕 ᚻႦᑪ৻㧘㐿␭ม㧚࠹ࠖ࠶ࠪࡘࠛࡦࠫ࠾ࠕ࡝ࡦࠣ 2006㧦↰⇌ᵏᒾ㧘ጟ㊁శᄦ✬㧚㛽࡮エ㛽ᒻᚑߢ௛ߊ⺃ዉ࿃ሶ, ᧲੩㧦ᣣᧄකቇ㙚㧧2006 ᐕ㧧18㧙23㧚
2㧕 ᚻႦᑪ৻㧚㤥ᧁ⊓ᔒᄦ㧘⸵ධᶈ✬㧚ᡷ⸓ၭ㙃⚦⢩ታ㛎ࡂࡦ࠼ࡉ࠶ࠢ, ᧲੩㧦⟠࿯␠㧧2008 ᐕ㧦314㧙318.
3㧕 ᚻႦᑪ৻㧘਄ጟኡ. ࡔࠞ࠾ࠞ࡞ࠬ࠻࡟ࠬߣ㛽㨪㛽⚦⢩ߩ↢‛ቇ߆ࠄ㛽࡝ࡕ࠺࡝ࡦࠣࠪࡒࡘ࡟࡯࡚ࠪࡦ߳㨪㛽☻㝃∝࡯⥃ᐥߣ⎇ⓥߩᦨᣂേะ, ᧲੩㧦කᱤ⮎಴ 㧧2008 ᐕ㧦76㧙80.
⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
1㧕 ࿡⽵㓉ᒄ㧚ES ⚦⢩(ਁ⢻⚦⢩)ߩ⎇ⓥߩ⃻⁁㧘⃻ઍකቇ 2006 ᐕ㧧54 Ꮞ㧦9㧙14.

㧙㧙2㧕 㕍ᧁੳ⟤㧘࿡⽵㓉ᒄ㧚ES ⚦⢩ߣ⋡ߩེቭᒻᚑ㧘ࠕ࠾࠹࠶ࠢࠬ 2006 ᐕ㧧19 Ꮞ㧦6㧙14.
3㧕 ⮮Ꮞ੫ੑ㧘ᚻႦᑪ৻㧚Notch ࠪࠣ࠽࡞ߣ⚦⢩ಽൻ㧘CLINICAL CALCIUM 2006 ᐕ㧧16 Ꮞ㧦114㧙119㧚
4㧕 ࿡⽵㓉ᒄ㧚ౣ↢ක≮ࠍᎼࠆᣂߚߥዷ㐿㧘ᣣᧄ⥃ᐥౝ⑼ቇળળ⹹ 2008 ᐕ㧧22 Ꮞ㧦533㧙542.
5㧕 ࿡⽵㓉ᒄ㧚⊕㜬ߩಽሶᯏ᭴㧘ᣣᧄ⊹⤏⑼ቇળ⹹ 2008 ᐕ㧧117 Ꮞ㧦2177㧙2178.
6㧕 㕍ᧁੳ⟤㧘࿡⽵㓉ᒄ㧚ᦨᣂߩࡔ࡜࠾ࡦ⦡⚛⎇ⓥߦߟ޿ߡ㧘ࡈ࡟ࠣ࡜ࡦࠬࠫࡖ࡯࠽࡞ 2008 ᐕ㧧36 Ꮞ㧦10㧙16.
✚⺑㧔᰷ᢥ㧕
1㧕 Motohashi T, Aoki H, Yoshimura N, Kunisada T. Induction of melanocytes from embryonic stem cells
and their therapeutic potential. Pigment Cell Res. 2006;19:284-289.
2㧕 Aoki H, Kunisada T. Colourless side of the nude mutation: Foxn1 and hair pigmentation. Pigment Cell
Melanoma Res. 2008;21:338-339.
ේ⪺㧔๺ᢥ㧕
ߥߒේ⪺㧔᰷ᢥ㧕
1㧕 Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K,
Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H. Genetic marking ofhematopoietic stem and endothelial cells: Identification of the Tmtsp gene encoding a novel
cell-surface protein with the thrombospondin-1 domain. Blood. 2006;107:4317-4325.
2㧕 Tezuka K, Takeda T, Wada Y, Takahashi A, Kikuchi M. Computer simulation of human mandible bone
structure by iBone, a novel reaction-diffusion bone remodeling model. Key Engineering Materials.
2006;306-308;1277-1282.
3㧕 Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.
Identification of genes expressed at the condensation stage of a chondrogenic cell line, ATDC5, by the
SST-REX method. J. Bone Miner Metabol. 2006;24:153-157.
4㧕 Fujimaki R, Toyama Y, Hozumi N, Tezuka K. Involvement of Notch signaling in initiation ofprechondrogenic condensation and formation of nodules in limb bud micromass cultures. J. Bone
Miner Metabol. 2006;24:191-198.
5㧕 Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H. Characterization of CD133+
hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun.
2006;351:820-824.
6㧕 D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR,
Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role ofMc1r in UV-induced tanning. Nature. 2006;443:340-344.
7㧕 Hara A, Niwa M, Kumada M, Aoki H, Kunisada T, Oyama T, Yamamoto T, Kozawa O, Mori H.
Intraocular injection of folate antagonist methotrexate induces neuronal differentiation of embryonicstem cells transplanted in the adult mouse retina. Brain Res. 2006;1085:33-42.
8㧕 Hara A, Niwa M, Aoki H, Kumada M, Kunisada T, Oyama T, Yamamoto T, Kozawa O, Mori H. A newmodel of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent,cobalt chloride. Brain Res. 2006;1109:192-200.
9㧕 Takahashi T, Kawai T, Ushikoshi H, Nagano S, Oshika H, Inoue M, Kunisada T, Takemura G,
Fujiwara H, Kosai KI. Identification and Isolation of Embryonic Stem Cell-Derived Target Cells byAdenoviral Conditional Targeting. Mol Ther. 2006;14:673-683.
10㧕 Tosaki H, Kunisada T, Motohashi T, Aoki H, Yoshida H, Kitajima Y. Mice transgenic for Kit(V620A):
recapitulation of piebaldism but not progressive depigmentation seen in humans with this mutation. J
Invest Dermatol. 2006;126:1111-1118.
11㧕 Aoki H, Hara A, Nakagawa S, Motohashi T, Hirano M, Takahashi Y, Kunisada T. Embryonic stem
cells that differentiate into RPE cell precursors in vitro develop into RPE cell monolayers in vivo. Exp
Eye Res. 2006;82:265-274.
12㧕 Motohashi T, Aoki H, Chiba K, Yoshimura N, Kunisada T. Multipotent cell fate of neural crest-likecells derived from embryonic stem cells. Stem Cells. 2007;25:402-410.
13㧕 Miyazono A, Yamada A, Morimura N, Takami M, Suzuki D, Kobayashi M, Tezuka K, Yamamoto M,
Kamijo R: TGF-b suppresses POEM expression through ERK1/2 and JNK in osteoblasts. FEBS Lett.
2007;581:5321-5326.
14㧕 Oka N, Soeda A, Inagaki A, Onodera M, Maruyama H, Hara A, Kunisada T, Mori H, Iwama T. VEGF
promotes tumorigenesis and angiogenesis of human glioblastoma stem cells. Biochem Biophys Res
Commun. 2007;360:553-559.
15㧕 Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T.
Long- term maintenance of brain tumor stem cell properties under at non-adherent and adherent
culture conditions. Biochem Biophys Res Commun. 2007;361:586-592.
16㧕 Hara A, Taguchi A, Niwa H, Aoki H, Yamada Y, Ito H, Nagata K, Kunisada T, Mori H. Localization of
septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of㧙㧙IF 10.896

IF 1.425

IF 1.425

IF 2.749

IF 28.751

IF 2.218

IF 2.218

IF 5.862

IF 4.829

IF 2.651
IF 7.531

IF 3.263

IF 2.904

IF 2.904photoreceptor cell degeneration. Neurosci Lett. 2007;423:205-210.
17㧕 Tomita H, Yamada Y, Oyama T, Hata K, Hirose Y, Hara A, Kunisada T, Sugiyama Y, Adachi Y,
Linhart H, Mori H. Development of gastric tumors in Apc Min/+ mice by the activation of theE-catenin/Tcf signaling pathway. Cancer Res. 2007;67:4079-4087.
18㧕 Miwa M, Inoue-Murayama M, Aoki H, Kunisada T, Hiragaki T, Mizutani M, Ito S. Endothelin receptor
B2 (EDNRB2) is associated with the panda plumage colour mutation in Japanese quail. Anim Genet.
2007;38:103-108.
19㧕 Aoki H, Hara A, Niwa M, Motohashi T, Suzuki T, Kunisada T. An in vitro mouse model for retinal
ganglion cell replacement therapy using eye-like structures differentiated from ES cells. Exp Eye Res.
2007;84:868-875.
20㧕 Takeda T, Tezuka Y, Horiuchi M, Hosono K, Iida K, Hatakeyama D, Miyaki S, Kunisada T, Shibata T,
Tezuka K: Characterization of Dental Pulp Stem Cells of Human Tooth Germs. J Dent Res.
2008;87:676-681.
21㧕 Aoki H, Hara A, Niwa M, Motohashi T, Suzuki T, Kunisada T. Transplantation of cells from eye-likestructures differentiated from embryonic stem cells in vitro and in vivo regeneration of retinal
ganglion-like cells. Graefes Arch Clin Exp Ophthalmol. 2008;246:255-265.
22㧕 Kawaguchi A, Chiba K, Tanimura Y, Motohashi T, Aoki H, Takeda T, Hayashi SI, Shimizu K,
Kunisada T. Isolation and characterization of Kit-independent melanocyte precursors induced in theskin of Steel factor transgenic mice. Dev Growth Differ. 2008;50:63-69.
23㧕 Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng H, Hara A, Aoki H, Kunisada T, Yamashita S,
Mori H. Further upregulation of beta-catenin/Tcf transcription is involved in the development ofmacroscopic tumors in the colon of ApcMin/+ mice. Carcinogenesis. 2008;29:666-672.
24㧕 Soeda A, Inagaki A, Oka N, Ikegame Y, Aoki H, Yoshimura SI, Nakashima S, Kunisada T, Iwama T.
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
J Biol Chem. 2008;383:10958-10966.
25㧕 Aoki H, Yoshida H, Hara A, Suzuki T, Kunisada T. Transplantation of melanocytes into iris: method foriris repigmentation. Transplantation. 2008;85:492-494.
26㧕 Hara A, Aoki H, Taguchi A, Niwa M, Yamada Y, Kunisada T, Mori H. Neuron-like Differentiation and
Selective Ablation of Undifferentiated Embryonic Stem Cells Containing Suicide Gene with Oct-4
Promoter. Stem Cells Dev. 2008;17:619-628.
27㧕 Tsuji Y, Yoshimura N, Aoki H, Sharov AA, Ko MS, Motohashi T, Kunisada T. Maintenance of
undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined
culture condition. Dev Dyn. 2008;237:2129-2138.
28㧕 Aoki H, Hara A, Motohashi T, Chem H, Kunisada T. Iris as a recipient tissue for pigment cells:
Organized in vivo differentiation of melanocytes and pigmented epithelium derived from embryonicstem cells in vitro. Dev Dyn. 2008;237:2394-2404.
29㧕 Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H. Differentiation of mouse
hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice withliver fibrosis. Transplantation. 2008;86:1178-86.

IF 2.085

IF 7.672

IF 2.640

IF 2.651

IF 3.496

IF 1.590

IF 1.908

IF 5.406

IF 5.581
IF 3.641

IF 3.224

IF 3.084

IF 3.084

IF 3.641

4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦࿡⽵㓉ᒄ㧧ࠦࠬࡔ࠻ࡠࠫ࡯⎇ⓥ⽷࿅⎇ⓥഥᚑ㧦⦡⚛⚦⢩ᐙ⚦⢩ߩ೙ᓮߦࠃࠆ⊕᢬∝ᴦ≮ࡕ࠺࡞ߩ㐿⊒㧧ᐔᚑ 17㧙18 ᐕᐲ㧧1,000 ජ౞(500㧦500)ජ౞
2㧕 ⎇ⓥઍ⴫⠪㧦࿡⽵㓉ᒄ㧧ጘ㒂ᄢቇ․೎ᢎ⢒⎇ⓥ⚻⾌㧦ࡅ࠻ ES ⚦⢩࡮⚵❱ᐙ⚦⢩ࠍ↪޿ߚ✂⤑ౣ↢ක≮ࡕ࠺࡞(േ‛ࡕ࠺࡞)ߩ⏕┙㧧ᐔᚑ 18㧙20 ᐕᐲ㧧62,000 ජ౞(44,000㧦12,00㧦6,000 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦ᚻႦᑪ৻㧧ᐔᚑ 18 ᐕᐲጘ㒂ᄢቇ↥ቭቇࡑ࠶࠴ࡦࠣࡈࠔࡦ࠼೙ᐲ㧦↢૕ࠪࡒࡘ࡟࡯࡚ࠪ
ࡦࠍ೑↪ߒߚᰴ਎ઍ CT ࠺࡯࠲⸃ᨆࠪࠬ࠹ࡓߩታ↪ൻ㧦ᐔᚑ 18 ᐕᐲ㧧3,800 ජ౞(3,800 ජ౞)
4㧕 ⎇ⓥઍ⴫⠪㧦ᚻႦᑪ৻㧧ᚢ⇛⊛ഃㅧ⎇ⓥផㅴ੐ᬺ ୘ੱဳ⎇ⓥ‫⑼(ޠߌ߇߈ߐޟ‬ቇᛛⴚᝄ⥝ᯏ᭴)㧦㛽
࡝ࡕ࠺࡝ࡦࠣࠪࡒࡘ࡟࡯࡚ࠪࡦߢ᜸߻࠹࡯࡜࡯ࡔࠗ࠼ౣ↢ක≮㧧ᐔᚑ 16㧙19 ᐕᐲ㧦42,262 ජ౞(22,049㧦10,613㧦7,600㧦2,000 ජ౞)
5㧕 ⎇ⓥઍ⴫⠪㧦ᧄᯅ ജ㧧ᐔᚑ 18 ᐕᐲ ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ၮ⋚⎇ⓥ(C)㧦␹⚻ႇ∝ᴦ≮ߦะߌߚ ES⚦⢩↱᧪ߩ␹⚻ႇ⚦⢩ߩಽൻᯏ᭴ߩ⸃ᨆ㧧ᐔᚑ 18㧙20 ᐕᐲ㧧4,400 ජ౞(2,000㧦1,500㧦900 ජ౞)
6㧕 ⎇ⓥઍ⴫⠪㧦ᚻႦᑪ৻㧧ᐔᚑ 19 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ⪚⧘⎇ⓥ㧦ࡅ࠻㛽∔ᖚࠪࡒࡘ࡟࡯࡚ࠪࡦߩ
ߚ߼ߩ㛽ᚑ㐳ࡕ࠺࡞ߩ᭴▽㧦ᐔᚑ 19㧙20 ᐕᐲ㧦3,200 ජ౞(230㧦90 ජ౞)
7㧕 ⎇ⓥઍ⴫⠪㧦ᚻႦᑪ৻㧧ᐔᚑ 19 ᐕᐲጘ㒂ᄢቇ↥ቭቇࡑ࠶࠴ࡦࠣࡈࠔࡦ࠼೙ᐲ㧦↢૕ࠪࡒࡘ࡟࡯࡚ࠪ
ࡦࠍ೑↪ߒߚᰴ਎ઍ CT ࠺࡯࠲⸃ᨆࠪࠬ࠹ࡓߩታ↪ൻ㧦ᚻႦᑪ৻㧦ᐔᚑ 19 ᐕᐲ㧦900 ජ౞8㧕 ⎇ⓥઍ⴫⠪㧦ᧄᯅ ജ㧧ᐔᚑ 18 ᐕᐲ ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ၮ⋚⎇ⓥ(C)㧦␹⚻ႇ∝ᴦ≮ߦะߌߚ ES⚦⢩↱᧪ߩ␹⚻ႇ⚦⢩ߩಽൻᯏ᭴ߩ⸃ᨆ㧧ᐔᚑ 18㧙19 ᐕᐲ㧧3,500 ජ౞(2,000㧦1,500 ජ౞)㧙㧙9㧕 ⎇ⓥઍ⴫⠪㧦ᧄᯅ ജ㧧ᐔᚑ 20 ᐕᐲ ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ၮ⋚⎇ⓥ(C)㧦ES ⚦⢩ࠍ೑↪ߒߚ␹⚻ႇ∝ᴦ≮ࡕ࠺࡞ߩ⏕┙࡮␹⚻ႇ⚦⢩ߩಽൻᯏ᭴ߩ⸃ᨆ㧧ᐔᚑ 20㧙22 ᐕᐲ㧧3,600 ජ౞(1,500㧦1,400㧦
700 ජ౞)10㧕 ⎇ⓥઍ⴫⠪㧦ᧄᯅ ജ㧧ᐔᚑ 20 ᐕᐲ ጘ㒂ᄢቇකቇㇱ⎇ⓥ⑼㐳࡮ቇㇱ㐳ⵙ㊂⚻⾌‫ޟ‬ᚑ૕⚵❱ߦሽ࿷ߔࠆᄙಽൻ⢻ࠍ᦭ߔࠆ␹⚻ႇ⚦⢩ߩหቯ෸߮ߘߩ⸃ᨆ‫ޠ‬ᐔᚑ 20 ᐕᐲ㧧500 ජ౞
11㧕 ⎇ⓥઍ⴫⠪㧦࿡⽵㓉ᒄ㧧JST ጊਛ iPS ․೎ࡊࡠࠫࠚࠢ࠻(⑼ቇᛛⴚᝄ⥝ᯏ᭴)㧦ᱤ⢦ᐙ⚦⢩߆ࠄߩ iPS⚦⢩ߩ⺃ዉല₸ߩ⏕⹺ߣࡅ࠻ iPS ⚦⢩ߩ⺃ዉ࿃ሶᷫዋൻߩᬌ⸛㧧ᐔᚑ 20㧙24 ᐕᐲ㧦50,000 ජ౞(10,000㧦10,000㧦10,000㧦10,000 ජ౞)
2㧕ฃ⸤⎇ⓥ1㧕 ᚻႦᑪ৻㧦↢૕ࠪࡒࡘ࡟࡯࡚ࠪࡦࠍ೑↪ߒߚᰴ਎ઍ CT ࠺࡯࠲⸃ᨆࠪࠬ࠹ࡓߩታ↪ൻ㧦ᐔᚑ 18 ᐕᐲ㧧
1,900 ජ౞㧦࡜࠻࠶ࠢࠪࠬ࠹ࡓࠛࡦࠫ࠾ࠕ࡝ࡦࠣ(ᩣ)
2㧕 ᚻႦᑪ৻㧦↢૕ࠪࡒࡘ࡟࡯࡚ࠪࡦࠍ೑↪ߒߚᰴ਎ઍ CT ࠺࡯࠲⸃ᨆࠪࠬ࠹ࡓߩታ↪ൻ㧦ᐔᚑ 19 ᐕᐲ㧧
819 ජ౞㧦࡜࠻࠶ࠢࠪࠬ࠹ࡓࠛࡦࠫ࠾ࠕ࡝ࡦࠣ(ᩣ)
3㧕 ࿡⽵㓉ᒄ㧦ᐙ⚦⢩ߩಓ⚿଻ሽߦ߅ߌࠆಓኂ଻⼔೷߅ࠃ߮ಓ⚿ᣇᴺߩ㐿⊒㧦ᐔᚑ 20 ᐕᐲ㧧2,000 ජ౞㧦ᄢ㓁ᣣ㉄(ᩣ)3㧕౒ห⎇ⓥߥߒ
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫ
1㧕 ࿡⽵㓉ᒄ㧦ࡈࠖ࡯࠳࡯⚦⢩ߩ㕖ሽ࿷ਅ㧘ήⴊᷡၭ࿾ਛߢ⢦ᕈᐙ⚦⢩ࠍᶋㆆၭ㙃ߔࠆߎߣࠍ․ᓽߣߔ
ࠆ㧘⢦ᕈᐙ⚦⢩ߩ⛽ᜬᣇᴺ㧧ᐔᚑ 18 ᐕ(․㗿 2006-051115). 
2㧕 ᚻႦᑪ৻㧘ᩊ↰ᢅਯ㧘࿡⽵㓉ᒄ㧘₹⟎਽೰㧘ᱞ↰⍮ሶ㧘ጊਛિᒎ㧘㜞ᯅ๺೑:ࡅ࠻ᱤ⢦ᐙ⚦⢩߆ࠄߩੱᎿᄙ⢻ᕈᐙ⚦⢩(iPS ⚦⢩)ߩ㜞ല₸⺃ዉᴺ㧧ᐔᚑ 20 ᐕ(಴㗿ᷣ).
3㧕 Tezuka, K., Shibata, T., Kunisada, T., Tamaoki, N., Takeda, T., Yamanaka, S., Takahashi, K.:
Efficientmethodforestablishing
inducedpluripotent
stem
cells.;2008(PCT/JP2008/08320(PCT/JP2008/068320)).
6㧚ቇળᵴേ
1㧕ቇળᓎຬ
࿡⽵㓉ᒄ㧦
1㧕 ᣣᧄ⦡⚛⚦⢩ቇળ੐ോዪ㐳࿖㓙⦡⚛⚦⢩ቇળᜂᒰℂ੐(2007 ᐕ㨪⃻࿷)2㧕 ᣣᧄౣ↢ᆔਔቇળ⹏⼏ຬ(㨪⃻࿷)2㧕ቇળ㐿௅
ߥߒ
3㧕ቇⴚ㔀⹹
ߥߒ
7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳࿡⽵㓉ᒄ㧦
1㧕 13th Meeting of the European Society for Pigment Cell Research (2006.09, Barcelona, Spain,
Symposium, Derivation of melanocyte precursors from embryonic stem cells and theirdifferentiation in vivo; Speaker)
2㧕 ╙ 82 ࿁ାᎺ⊹⤏⣲≌ᙣ⹤ળ(ᐔᚑ 18 ᐕ 2 ᦬㧘᧻ᧄ㧘․೎⻠Ṷ‫⚦⚛⦡ޟ‬⢩ᐙ⚦⢩ߩേᘒߣࡔ࡜ࡁ࡯ࡑ
ᐙ⚦⢩‫ޠ‬Ṷ⠪)3㧕 ╙ 3 ࿁ጘ㒂⣖⑼ቇ⎇ⓥળ(ᐔᚑ 18 ᐕ 11 ᦬㧘ጘ㒂㧘᜗ᓙ⻠Ṷ‫ޟ‬ES ⚦⢩ࠍ↪޿ߚ⌒ߩౣ↢ක≮ߩน⢻ᕈ‫ޠ‬Ṷ⠪)
4㧕 ╙ 106 ࿁ᣣᧄ⊹⤏⑼ቇળ✚ળ(ᐔᚑ 19 ᐕ 4 ᦬㧘ᮮᵿ㧘ᢎ⢒⻠Ṷ 12‫⚦⚛⦡ޟ‬⢩ߩ↢‛ቇ‫ޠ‬㧘⊕㜬ߩಽሶᯏ᭴(࿡⽵㧘ᧄᯅ㧘㕍ᧁ) Ṷ⠪)
5㧕 ╙ 28 ࿁ᣣᧄἻ∝࡮ౣ↢කቇળ(ᐔᚑ 19 ᐕ 8 ᦬㧘᧲੩㧘ࠪࡦࡐࠫ࠙ࡓ 2‫⚻␹ޟ‬ႇ⚦⢩㧦↢૕ᐙ⚦⢩ߣ㧙㧙ߒߡߩน⢻ᕈ‫ޠ‬㧘ES ⚦⢩߆ࠄ⺃ዉߒߚ␹⚻ႇ᭽⚦⢩ߩಽൻ⢻ജ(ᧄᯅജ㧘㕍ᧁੳ⟤㧘࿡⽵㓉ᒄ) Ṷ⠪)
6㧕 ╙ 3 ࿁ᣣᧄ⥃ᐥౝ⑼කቇળ(ᐔᚑ 19 ᐕ 9 ᦬㧘․೎⻠ṶΧ‫ޟ‬ౣ↢ක≮ࠍᎼࠆᣂߚߥዷ㐿‫ޠ‬Ṷ⠪)7㧕 ╙ 21 ࿁ᣣᧄ⦡⚛⚦⢩ቇળᐕᰴቇⴚᄢળ(ᐔᚑ 19 ᐕ 12 ᦬㧘৻⥸Ṷ㗴 1.ࡔ࡜ࡁࠨࠗ࠻ߩಽൻ ᐳ㐳)8㧕 ᄢ㓁ᣣ㉄ࡔࠫࡖ࡯ࠢ࡜ࡉ ਛㇱࡔ࠺ࠖࠞ࡞ળ✚ળ(ᐔᚑ 19 ᐕ 6 ᦬㧘᜗ᓙ⻠Ṷ‫ޟ‬ౣ↢ක≮ߩㅴዷߣߘࠇ
ࠍᡰ߃ࠆࠟࠬᛛⴚ‫ޠ‬Ṷ⠪)9㧕 20th International Pigment Cell Conference and 5th International Melanoma Research Congress(2008.05, Hokkaido, ࠨ࠹࡜ࠗ࠻ࠪࡦࡐࠫ࠙ࡓ, Melanocytes in eye, harderian gland and ear:Different requirement of Kit and Endothelin 3 signalings for the development of non-cutaneous
melanocytes, invited co-author)
10㧕 20th International Pigment Cell Conference and 5th International Melanoma Research Congress(2008.05, Hokkaido, Signal transduction and life cycle of melanocytes, invited speaker)
11㧕 20th International Pigment Cell Conference and 5th International Melanoma Research Congress(2008.05, Hokkaido, CS-09:Signaling cascade in melanocyte and melanoma, co-chair person)
12㧕 ᖱႎᯏ᭴ਥ௅ߦࠃࠆౣ↢ක≮࠮ࡒ࠽࡯(ᐔᚑ 20 ᐕ 7 ᦬㧘᧲੩㧘‫ޟ‬ᐙ⚦⢩ࠍ↪޿ߚౣ↢ක≮ߩน⢻ᕈ‫ޠ‬Ṷ⠪)
13㧕 ᾢᧄᄢቇࠣࡠ࡯ࡃ࡞ COE ࡝ࠛ࠱ࡦ࡜ࡏ⎇ⓥળ(ᐔᚑ 20 ᐕ 10 ᦬㧘ᾢᧄ㧘᜗ᓙ⻠Ṷ‫ޟ‬Establishment of
iPS cell bank from dental pulp stem cells and its possible use for regenerative medicine‫ޠ‬Ṷ⠪)ජ
14㧕 ╙ 24 ࿁᡼ᓇ⎇㊀☸ሶක⑼ቇ࠮ࡦ࠲࡯⎇ⓥ੤ᵹળ(వ┵ㆮવሶ⊒⃻⎇ⓥࠣ࡞࡯ࡊ)(ᐔᚑ 20 ᐕ 10 ᦬㧘⪲㧘᜗ᓙ⻠Ṷ‫ޟ‬ጘ㒂ᄢቇᱤ⢦ᐙ⚦⢩ࡃࡦࠢ߅ࠃ߮ iPS ⚦⢩ࡃࡦࠢߩ᮸┙ߣ iPS ⚦⢩ࠍ↪޿ߚౣ↢ක≮ߩน⢻ᕈ‫ޠ‬Ṷ⠪)ᚻႦᑪ৻㧦
1㧕 ╙ 111 ࿁ᣣᧄ⸃೬ቇળ✚ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ᶆ๺(ർ㉿ᄢቇ)㧘᜗ᓙࠪࡦࡐࠫࠬ࠻‫ޟ‬㛽࡝ࡕ࠺࡝ࡦࠣࠪ
ࡒࡘ࡟࡯࡚ࠪࡦ‫ޟ‬iBone‫ޠ‬㨪⚦⢩ߦࠃࠆᦨㆡ᭴ㅧ⸳⸘㨪‫ޠ‬Ṷ⠪)2㧕 ↥ቇቭ࠹ࠢࡁࡊ࡜ࠩጘ㒂(ᐔᚑ 18 ᐕ 2 ᦬㧘›ጊ㧘᜗ᓙ⻠Ṷ‫ޟ‬㛽࡝ࡕ࠺࡝ࡦࠣࠪࡒࡘ࡟࡯࡚ࠪࡦࠍ೑
↪ߒߚᣂߒ޿ౣ↢ක≮ᛛⴚ‫ޠ‬Ṷ⠪)
3㧕 ࡃࠗࠝࡈ࡜ࠬࠦᚢ⇛ࡢ࡯࡚ࠢࠪ࠶ࡊ(ᐔᚑ 19 ᐕ 3 ᦬㧘᧲੩(⑼ቇᛛⴚᝄ⥝ᯏ᭴ ⎇ⓥ㐿⊒ᚢ⇛࠮ࡦ࠲࡯)㧘⹤㗴ឭଏ‫↢ޟ‬๮ࠪࠬ࠹ࡓߩࡠࠫ࠶ࠢߩ᛽಴ ᯏ᪾ࠪࠬ࠹ࡓ߳ߩ⠡⸶࡮ォ౮‫ޠ‬Ṷ⠪)
4㧕 ᣣᧄᱤ⑼ℂᎿቇળਛㇱᡰㇱᄐᦼ࠮ࡒ࠽࡯(ᐔᚑ 20 ᐕ 8 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫▚⸘ޟ‬ᯏࠪࡒࡘ࡟࡯࡚ࠪ
ࡦ iBone ࠍ૶ߞߚ࠹࡯࡜࡯ࡔࠗ࠼㛽ౣ↢ක≮‫ޠ‬Ṷ⠪)ᧄᯅ ജ㧦
1㧕 ╙ 44 ࿁ᣣᧄዊఽᄖ⑼ቇቇળ✚ળ(ᐔᚑ 19 ᐕ 5 ᦬㧘᧲੩㧘ࠪࡦࡐࠫ࠙ࡓ‫∛ߩ∛ࠣࡦ࡞ࡊࠬࡘࠪ࡞ࡅޟ‬࿃⺰‫ޠ‬Ṷ⠪)2㧕 20th International Pigment Cell Conference and 5th International Melanoma Research Congress(2008.05, Hokkaido, Multipotent cell fates of melanocyte precursors isolated from embryonicand neonatal skin, speaker)
8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫߥߒ9㧚␠ળᵴേᧄᯅ ജ㧦
1㧕 ๺᱌ጊ⋵┙ᣣ㜞㜞╬ቇᩞࠬ࡯ࡄ࡯ࠨࠗࠛࡦࠬࡂࠗࠬࠢ࡯࡞․೎⻠⟵‫ࠆ߆ࠊޟ‬ౣ↢කቇ ES ⚦⢩࡮iPS⚦⢩ࠍℂ⸃ߒࠃ߁‫(ޠ‬2008 ᐕ 10 ᦬ 27 ᣣ ๺᱌ጊ⋵ᓮဌᏒ ⋵┙ᣣ㜞㜞╬ቇᩞ)10㧚ႎ๔ᦠ
1㧕 ᚻႦᑪ৻㧦ⶄ㔀♽㛽࡝ࡕ࠺࡝ࡦࠣࠪࡒࡘ࡟࡯࡚ࠪࡦࠍ೑↪ߒߚࡅ࠻㛽∔ᖚࡕ࠺࡞ߩ⸃ᨆ㧦ᐔᚑ 16 ᐕᐲ㧙17 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄(ၮ⋚⎇ⓥ C)⎇ⓥᚑᨐႎ๔ᦠ㧦1㧙41(2006 ᐕ 3 ᦬)
2㧕 ᧄᯅ ജ㧦␹⚻ႇ∝ᴦ≮ߦะߌߚ ES ⚦⢩↱᧪ߩ␹⚻ႇ⚦⢩ߩಽൻᯏ᭴ߩ⸃ᨆ㧦ᐔᚑ 18 ᐕᐲ㧙19 ᐕ
ᐲ ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(C)ᚑᨐႎ๔ᦠ㧦1㧙49(2008 ᐕ 3 ᦬)㧙㧙

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1㧕 ࿡⽵㓉ᒄ㧦⺒ᄁᣂ⡞ᦺೀ 㨬ᐙ⚦⢩ߩ੹㧘਎⇇ߩ⎇ⓥ࡟࡯ࠬടㅦ㨭(2006 ᐕ 5 ᦬ 29 ᣣ)2㧕 ࿡⽵㓉ᒄ㧦࡜ࠫࠝ NIKKEI‫⊕ޠ࡯࠽ࡒ࠮⑼⤏⊹ࡎ࡞ࡑޟ‬㜬ߩಽሶᯏ᭴(2007 ᐕ 10 ᦬ 23 ᣣ)
3㧕 ᚻႦᑪ৻㧦ጘ㒂ᣂ⡞ᦺೀ ‫ޟ‬㛽ߩᒻត᳞㧘ක≮ᔕ↪⋡ᜰߔ‫(ޠ‬2008 ᐕ 1 ᦬ 15 ᣣ)
4㧕 ࿡⽵㓉ᒄ㧦ጘ㒂ᣂ⡞ᦺೀ ‫ޟ‬ᣣᧄੱ⚦⢩߆ࠄਁ⢻⚦⢩‫(ޠ‬2008 ᐕ 4 ᦬ 9 ᣣ)
12㧚⥄Ꮖ⹏ଔ⹏ଔ
3 ᐕ㑆ߩ⎇ⓥ⺰ᢥߩᢙ㧘ࠗࡦࡄࠢ࠻ߦ㑐ߒߡߪਇ⿷ߪߥ޿‫⎇ޕ‬ⓥ⊒⴫ߦ㑐ߒߡߪ㧘࿖㓙ቇળߢߩ⊒⴫ࠍჇ߿ߔᔅⷐ߇޽ࠆ‫┹ޕ‬੎⊛⎇ⓥ⾌ߩ₪ᓧߪචಽߣߪ⸒߃ߥ޿߇㧘౒ห⎇ⓥ࡮౒ห೑↪ߦࠃࠅ⚻⾌ߩ▵ᷫࠍ࿑ߞߡ߽߅ࠅ㧘ᷓೞߥਇ⿷ߦߪ㒱ߞߡ޿ߥ޿‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷⎇ⓥኻ⽎߇᜛ᢔ᳇๧ߢ㧘⎇ⓥ⠪࡮ቇ↢ᢙࠍൊ᩺ߔࠇ߫චಽߥ⎇ⓥᚑᨐࠍ᜼ߍߡ޿ࠆ߇㧘ࠗࡦࡄࠢ࠻ߩ
㜞޿ᚑᨐ⊒⴫ߦߪߟߥ߇ߞߡ޿ߥ޿‫ߪߩ޿ߥࠇ߈ࠅ⛉ࠍࡑ࡯࠹ޕ‬㧘෩ߒ޿⎇ⓥ⾌₪ᓧߩ⁁ᴫ㧔ᒰಽ㊁ߩ⑼ቇ⎇ⓥ⾌ណᛯ₸߇ૐ޿㧕ࠍᛂ㐿ߔߴߊ㧘޽ࠆ⒟ᐲ⾗㊄ߩឭଏవߦวࠊߖߚ⎇ⓥࠍߖߑࠆࠍᓧߥ޿ߣ޿
߁⁁ᴫߩ෻ᤋߢ߽޽ࠅ㧘ࠫ࡟ࡦࡑߦ㒱ߞߡ޿ࠆ‫ޕ‬
ᒰಽ㊁ߩࠬ࠲࠶ࡈߪฦ⥄ᔅⷐߥദജࠍᕃߞߡߪ޿ߥ޿߇㧘ᄢቇ㒮౉ቇ⠪ߩᷫዋߣ߽㊀ߥࠅ㧘⥄ഥദജߢ഍⊛ߥࡄࡈࠜ࡯ࡑࡦࠬߩะ਄ࠍ⸘ࠇࠆ߆ߪ⇼໧ߢ޽ࠆ‫ޕ‬ઃട⊛ߥ⸥ㅀࠍ⸵ߒߡ߽ࠄ߃ࠆߥࠄ㧘ጘ㒂ᄢቇකቇㇱో૕ߦ߅ߌࠆ⎇ⓥᓥ੐⠪ߩᕆᷫߣ㧘ࠃࠅ⦟޿⎇ⓥⅣႺࠍ᳞߼ߡߩఝ⑲ߥቇౝ⎇ⓥ⠪ߩቇᄖ߳ߩᵹᄬߪ㧘ᒰಽ㊁ߦ㒢ࠄߕၮ␆ฦಽ㊁ߦ߅ߌࠆ⎇ⓥߩ㊂ߣ⾰ߩਔᣇࠍૐਅߐߖ㧘ጘ㒂ᄢቇකቇㇱߦ߅ߌࠆၮ␆⎇ⓥࠍუṌߐߖࠆᕟࠇ߇޽ࠆ‫ޕ‬ጘ㒂ᄢቇකቇㇱߩ⎇ⓥ⢻ജࠍ⛽ᜬߒ㧘ఝ⑲ߥᓟ⛮⠪ࠍ⢒ᚑߔࠆߚ߼ߩౕ૕⊛ߥࡊ࡜ࡦߩ૞⵾ߣታⴕ߇ᕆോߣ⠨߃ࠆ‫ޕ‬੹ᓟߩዷᦸᭉⷰ⊛ߥⷐ⚛ߪ⊝ήߢߪ޽ࠆ߇㧘iPS ⚦⢩ࠍਛᔃߦߒߚᣂߒ޿⎇ⓥ࠹࡯ࡑࠍᓥ᧪ߩౣ↢ක≮⎇ⓥߦขࠅㄟߺ㧘⎇ⓥߩ⾰ߣ㊂ߩࡃ࡜ࡦࠬߦ㈩ᘦߒߚ⁛⥄ߩ⎇ⓥࠍⴕ߁ߎߣߢ޽ࠆ⒟ᐲߪෂᯏ⊛⁁ᴫ߇࿁ㆱน⢻ߣ⠨߃ࠆ‫ޕ‬ቇౝߢലᨐ⊛ߥ౒ห⎇ⓥࠍⴕ޿㧘࡝࠰࡯ࠬߣᖱႎࠍ᦭ലߦᵴ↪ߔࠆߎߣ߽৻ጀⓍᭂ⊛ߦⴕ޿
ߚ޿‫ޕ‬

㧙㧙

㧔2㧕␹⚻↢‛ಽ㊁1㧚⎇ⓥߩ᭎ⷐ
ౣ↢ක⑼ቇኾ᡹ ౣ↢ಽሶ⛔ᓮቇ⻠ᐳ ␹⚻↢‛ಽ㊁ߢߪ㧘ಽሶ↢‛ቇ߅ࠃ߮⚦⢩↢‛ቇߦ߅ߌࠆᦨᣂߩ
ᛛⴚࠍ㚟૶ߒ㧘␹⚻ᄌᕈ∔ᖚߩ∛ᘒ⸃᣿㧘ߐࠄߦᴦ≮ᴺߩ㐿⊒ࠍ⋡ᜰߒߚᢎ⢒ߣ⎇ⓥࠍⴕߞߡ޿ࠆ‫⚻␹ޕ‬ᄌᕈ∔ᖚߩᄙߊߪ㔍ᴦᕈߢ޽ࠅ㧘ᴦ≮ᴺߩ㐿⊒߇ᕆോߢ޽ࠆ‫∛ߪߦ߼ߚߩߘޕ‬ᘒߩ⸃᣿߇ᦨఝవ⺖㗴ߢ޽ࠅ㧘කቇߩߺߥࠄߕ⚦⢩↢‛ቇ㧘ಽሶ↢‛ቇ㧘↢ൻቇߥߤฦኾ㐷ಽ㊁ࠍⲢวߒߚ Interdisciplinary
Research and Education㧔ቇ㓙⊛⎇ⓥ߅ࠃ߮ᢎ⢒㧕߇ᔅⷐߢ޽ࠆ‫ᧄޕ‬ಽ㊁ߩᢎ⢒ߣ⎇ⓥߪ⎇ⓥቶߩࡎ࡯ࡓࡍ࡯ࠫ㧔http://www1.gifu-u.ac.jp/~neurobio/㧕ߦ⸥タߒߡ޿ࠆ߇㧘એਅߦᦨᣂߩ㧔ᐔᚑ 20 ᐕ⃻࿷㧕⎇ⓥߣᢎ⢒ౝኈࠍ␜ߔ‫ޕ‬
A. ⎇ⓥ
1㧚㔍ᴦᕈ␹⚻ᄌᕈ∔ᖚߦ߅ߌࠆዊ⢩૕ࠬ࠻࡟ࠬߩᓎഀߩ⸃᣿
ዊ⢩૕ߪ⚦⢩ౝዊེቭߢ޽ࠅ㧘⚦⢩ౝࠞ࡞ࠪ࠙ࡓỚᐲ⺞▵߅ࠃ߮࠲ࡦࡄࠢ⾰ߩୃ㘼ࠍⴕ޿㧘↢๮⃻⽎ߦ߅ߌࠆ⚦⢩ᯏ⢻⛽ᜬ߅ࠃ߮ᖱႎવ㆐ߦ㊀ⷐߥᓎഀࠍᨐߚߒߡ޿ࠆ‫ߩߘޕ‬ᯏ⢻߇㓚ኂߐࠇࠆߣዊ⢩૕ࠬ࠻࡟ࠬߣ
๭߫ࠇࠆ⃻⽎߇߅ߎࠅ㧘ዊ⢩૕ౝߦ᛬ࠅ⇥ߺ⇣Ᏹࠍ⿠ߎߒߚ࠲ࡦࡄࠢ⾰߇⫾Ⓧߔࠆ‫⚦ޕ‬⢩ߪᯏ⢻ࠍᱜᏱߥ⁁ᘒߦᚯߔࠃ߁ߦዊ⢩૕⤑਄ߦሽ࿷ߔࠆ࠲ࡦࡄࠢ⾰ࠍᵴᕈൻ㧔ዊ⢩૕ࠬ࠻࡟ࠬᔕ╵㧕ߔࠆ߇㧘ߘߩ⎕✋ߦࠃࠅ⚦⢩ᱫ߇⺃ዉߐࠇࠆ㧔ਛᎹ╬, Nature 2000㧕‫ᧄޕ‬ಽ㊁ߢߪ㧘ዊ⢩૕ࠬ࠻࡟ࠬ೙ᓮ࿃ሶ߅ࠃ߮ࠕ࡞࠷ࡂࠗࡑ࡯
∛ߦ߅ߌࠆࠕࡒࡠࠗ࠼-ࡌ࡯࠲↥↢ߦ㑐ਈߔࠆࠟࡦࡑ-࠮ࠢ࡟࠲࡯࠯೙ᓮ࿃ሶࠍࠥࡁࡓࡢࠗ࠼ߦࠬࠢ࡝࡯࠾ࡦ
ࠣߔࠆᣇᴺࠍ⏕┙ߒ㧘ࠕ࡞࠷ࡂࠗࡑ࡯∛㧘ࡂࡦ࠴ࡦ࠻ࡦ∛ߩᴦ≮ᴺ㐿⊒ࠍ⋡ᜰߒߚᢎ⢒ߣ⎇ⓥࠍⴕߞߡ޿ࠆ‫ޕ‬㧔ࠕ㧕 ࡂࡦ࠴ࡦ࠻ࡦ∛㧦Ᏹᨴ⦡૕ఝᕈㆮવ᭽ᑼࠍ␜ߒ㧘ਇ㓐ᗧㆇേߣ♖␹␹⚻∝⁁ࠍ․ᓽߣߔࠆ␹⚻ᄌᕈ∔ᖚߢ޽ࠆ‫ޕ‬ㆮવሶᄌ⇣ߦࠃࠅࠣ࡞࠲ࡒࡦ߇ᄙᢙㅪ⛯ߒ㧘␹⚻ᄌᕈࠍ߈ߚߔߣ⠨߃ࠄࠇߡ޿ࠆ߇㧘ߘߩᯏ᭴ߩ⹦⚦ߪਇ᣿ߩ߹߹ߢ޽ࠆ‫ᧄޕ‬ಽ㊁ߢߪ㧘ࡂࡦ࠴ࡦ࠻ࡦ∛ࡕ࠺࡞ࡑ࠙ࠬߦ߅޿ߡ㧘ዊ⢩૕ߩᒻᘒ⇣Ᏹࠍ᣿ࠄ߆ߦߒ㧘ߘߩ⇣Ᏹ߆ࠄ∛ᘒߩ⸃᣿ࠍ⋡ᜰߒߡ޿ࠆ‫ޕ‬㧔ࠗ㧕 ࠕ࡞࠷ࡂࠗࡑ࡯∛㧦ᣣᧄ࿖ౝߛߌߢ߽ 205 ਁੱ㧔2005 ᐕ㧕㧘30 ᐕᓟߩ 2035 ᐕߦߪ⚂ 2.2 ୚ߩ 445ਁੱߩᖚ⠪ᢙߦ㆐ߔࠆߣ੍ᗐߐࠇࠆ⹺⍮∝ࠍ߈ߚߔઍ⴫⊛ߥ∔ᖚߢ޽ࠆ‫ߒ߆ߒޕ‬㧘ߘߩ 90 ࡄ࡯࠮ࡦ࠻એ਄ߪㆮવሶᄌ⇣ࠍ⹺߼ߥ޿ߚ߼㧘ේ࿃߽ਇ᣿ߩ߹߹ߢ޽ࠆ‫ߒ߆ߒޕ‬㧘ኅᣖᕈࠕ࡞࠷ࡂࠗࡑ࡯
∛ߩ⎇ⓥ߆ࠄ㧘ࠕࡒࡠࠗ࠼-ࡌ࡯࠲↥↢ߦ㑐ࠊࠆࠟࡦࡑ-࠮ࠢ࡟࠲࡯࠯ߩ∛ᘒ߳ߩ㑐ਈ߇␜ໂߐࠇߡ
޿ࠆ‫ᧄޕ‬ಽ㊁ߢߪ㧘㕖ኅᣖᕈࠕ࡞࠷ࡂࠗࡑ࡯∛ߩ∛ᘒߩ⸃᣿ࠍ⋡ᜰߒ㧘ࠟࡦࡑ-࠮ࠢ࡟࠲࡯࠯ᵴᕈߩ
೙ᓮᯏ᭴ߩ⸃᣿ߦ㑐ߔࠆ⎇ⓥࠍⴕߞߡ޿ࠆ‫ޕ‬
2㧚␹⚻⚦⢩․⇣⊛ߥ⚦⢩ᱫ㑐ㅪㆮવሶߩหቯߣᯏ⢻⸃ᨆࠞࠬࡍ࡯ࠬ㧔ࠪࠬ࠹ࠗࡦࡊࡠ࠹ࠕ࡯࠯㧕ߪ✢⯻߆ࠄູ੃㘃߹ߢ⋧หㆮવሶ߇ሽ࿷ߒ㧘ࠕࡐ࠻࡯ࠪࠬ㧔⚦⢩ᱫ㧕ࠍ⺃ዉߔࠆࡊࡠ࠹ࠕ࡯࠯ߣߒߡਛᔃ⊛ߥᓎഀࠍᨐߚߒߡ޿ࠆ‫ᧄޕ‬ಽ㊁ߢߪ㧘ࠞࠬࡍ࡯ࠬߩᓎഀ㧘․ߦ㔍ᴦᕈ␹⚻∔ᖚ㧔⣄㜑ዊ⣖ᄌᕈ∝㧕߳ߩ㑐ਈࠍ⸃᣿ߔࠆߚ߼㧘ࠬࡕ࡯࡞ࡊ࡯࡞ cDNA ࡜ࠗࡉ࡜࡝࡯ࠍ
૶ߞߚㆮવሶߩࠢࡠ࡯࠾ࡦࠣᴺߦࠃࠆㆮવሶߩหቯߣᯏ⢻⸃ᨆࠍⴕߞߡ޿ࠆ‫⸃ߩߎޕ‬ᨆߦߡ㧘␹⚻∔ᖚߩේ࿃ㆮવሶࠍหቯߒ㧘ᯏ⢻߅ࠃ߮∛ᘒߩ⸃ᨆ߆ࠄᴦ≮ᴺ㐿⊒ߦะߌߚᢎ⢒ߣ⎇ⓥࠍⴕߞߡ޿ࠆ‫ ޕ‬
3㧚ᄢ⣖⊹⾰ㆇേㅪว㊁߅ࠃ߮೨ᐸ␹⚻♽ߩਛᨔᯏᐨߩ⎇ⓥ
㔚᳇↢ℂቇ⊛ᚻᴺࠍ↪޿, ␹⚻ᯏ⢻ߩ⸃ᨆࠍⴕߞߡ޿ࠆ‫ޕ‬
B. ᢎ⢒
ᄢቇ㒮↢㧔ඳ჻೨ᦼ߅ࠃ߮ᓟᦼ㧕ߪ㧘዁᧪㧔ᰴ਎ઍ㧕ߩ⎇ⓥ⠪ߦߥࠆߚ߼ߦ㧘⻉ᄖ࿖ߢⴕࠊࠇߡ޿ࠆࡊ
ࡠࠣ࡜ࡓࠍෳ⠨ߦߒߚᢎ⢒ߣ⎇ⓥᜰዉ߇ᔅⷐߛߣ⠨߃ߡ޿ࠆ‫߼ߚߩߘޕ‬㧘ᧄಽ㊁ߢߪએਅߩ⢻ജࠍୃᓧߔ
ࠆߎߣࠍ⋡ᜰߒߚᢎ⢒ᜰዉࠍⴕߞߡ޿ࠆ‫ޕ‬x ୘‫ߩޘ‬ታ㛎⚿ᨐࠍ⠨ኤߔࠆ⢻ജx ⥄ಽߩ⎇ⓥᚑᨐࠍ߹ߣ߼ࠆ⢻ജx ⎇ⓥᚑᨐࠍ⊒⴫ߔࠆ⢻ജx ⸛⺰ߔࠆ⢻ജx ⧷⺆⢻ജ㧔⧷⺆ജࠍりߦߟߌࠆߚ߼㧘ᄢቇ㒮↢߇ਛᔃߣߥࠅ Molecular Biology of THE CELL, Cell
Biology ࠍᲤㅳ⺒ࠎߢ޿ࠆ‫ߚ߹ޕ‬㧘࡜ࡏࡒ࡯࠹ࠖࡦࠣࠍ฽߼㧘น⢻ߥ㒢ࠅ⧷⺆ߢߩࠦࡒࡘ࠾ࠤ࡯࡚ࠪ
ࡦࠍⴕߞߡ޿ࠆ‫ޕ‬
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2㧚ฬ★
ਛᎹᢅᐘ
ᢎ᝼㧦
ಎᢎ᝼㧦 Ꮉፉ ථ
૒┻⵨ቁ
⻠Ꮷ㧦

Toshiyuki Nakagawa
Takashi Kawashima
Hirotaka Satake㧙㧙3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
ߥߒ⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
ߥߒ✚⺑㧔᰷ᢥ㧕
ߥߒේ⪺㧔๺ᢥ㧕
ߥߒේ⪺㧔᰷ᢥ㧕
1㧕 Hayakawa Y, Itoh M, Yamada A, Mitsuda T, Nakagawa T. Expression and localization of Cayman
ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner.
Brain Res. 2007;1129:100-109.
2㧕 Mitsuda T, Hayakawa Y, Itoh M, Ohta K, Nakagawa T. ATF4 regulates -secretase activity during
amino acid imbalance. Biochem Biophys Res Commun. 2007;352:722-727.
3㧕 Takai Y, Matikainen T, Jurisicova A, Kim MR, Trbovich AM, Fujita E, Nakagawa T, Lemmers B,
Flavell RA, Hakem R, Momoi T, Yuan J, Tilly JL, Perez GI. Caspase-12 compensates for lack of
caspase-2 and caspase-3 in female germ cells. Apoptosis. 2007;12:791-800.
4㧕 Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H.
Epidermal growth factor signaling mediated by grb2 associated binderl is required for the
spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.
Stem Cells. 2007;25:1410-1422.
5㧕 Song S, Lee H, Kam TI, Tai ML, Lee JY, Noh JY, Shim SM, Seo SJ, Kong YY, Nakagawa T, Chung
CW, Choi DY, Oubrahim H, JungYK. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated A
neurotoxicity. J Cell Biol. 2008;182:675-684.

IF 2.218
IF 2.749

IF 3.043

IF 7.531

IF 9.5984㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄ਛᎹᢅᐘ㧦1㧕 ⎇ⓥઍ⴫⠪㧦ਛᎹᢅᐘ㧧ᐔᚑ 17 ᐕᐲ⥄ὼ⑼ቇ♽⎇ⓥഥᚑ㊄㧔ᣩ⎣ሶ⽷࿅㧕㧦ዊ⢩૕߆ࠄ⊒ାߐࠇࠆ⚦⢩ᱫࠪࠣ࠽࡞ߦࠃࠆࠞࠬࡄ࡯࠯ᵴᕈൻᯏ᭴ߩ⸃᣿㧧ᐔᚑ 17㧙18 ᐕᐲ㧧5,000 ජ౞(4,000㧦1,000ජ౞)
2㧕 ⎇ⓥઍ⴫⠪㧦ਛᎹᢅᐘ㧘 ⎇ⓥಽᜂ⠪㧦ᣧᎹ૫⧐㧧⑼ቇ⎇ⓥ⾌․ቯ㗔ၞ⎇ⓥ㧦ᯏ⢻⊛ࠬࠢ࡝࡯࠾ࡦࠣ
ᴺߩ⏕┙ߦࠃࠆዊ⢩૕ࠬ࠻࡟ࠬ೙ᓮ࿃ሶߩ✂⟜⊛ត⚝࡮ᯏ⢻⸃ᨆ㧧ᐔᚑ 17㧙18 ᐕᐲ㧦5,800 ජ౞(2,900㧦2,900 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦ਛᎹᢅᐘ㧧⑼ቇ⎇ⓥ⾌⵬ഥ㊄⪚⧘⎇ⓥ㧦ォ౮࿃ሶ ATF4 ߦࠃࠆࠟࡦࡑ࡯࠮ࠢ࡟࠲࡯࠯
ᵴᕈൻߩ೙ᓮᯏ᭴ߩ⸃᣿㧧ᐔᚑ 19㧙21 ᐕᐲ㧧3,100 ජ౞(1,500㧦900㧦700 ජ౞)
4㧕 ⎇ⓥઍ⴫⠪㧦ਛᎹᢅᐘ㧧⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦⣖ౝࠕࡒࡁ㉄ࡃ࡜ࡦࠬ⇣Ᏹߦࠃࠆ⹺⍮∝⊒∝ᯏ᭴ߩ⸃᣿㧧ᐔᚑ 20㧙22 ᐕᐲ㧧14,200 ජ౞(7,800㧦3,600㧦2,800 ජ౞)⍫㊁(ᣧᎹ)૫⧐㧦1㧕 ⎇ⓥઍ⴫⠪㧦⍫㊁(ᣧᎹ)૫⧐㧧⑼ቇ⎇ⓥ⾌⵬ഥ㊄(⧯ᚻ⎇ⓥ B)㧦ࠪ࠽ࡊࠬߦ߅ߌࠆዊ⣖ㆇേᄬ⺞∝ේ࿃ಽሶ Caytaxin ߩᯏ⢻⸃ᨆ; ᐔᚑ 19 ᐕᐲ㧧1,300 ජ౞
2㧕ฃ⸤⎇ⓥߥߒ
3㧕౒ห⎇ⓥߥߒ㧙㧙5㧚⊒᣿࡮․⸵಴㗿⁁ᴫߥߒ
6㧚ቇળᵴേ
1㧕ቇળᓎຬ
ߥߒ
2㧕ቇળ㐿௅
ߥߒ
3㧕ቇⴚ㔀⹹
ߥߒ
7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳ਛᎹᢅᐘ㧦
1㧕 ╙ 3 ࿁ዊ⢩૕ࠬ࠻࡟ࠬ⎇ⓥળ(2008 ᐕ 10 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫ࠆߌ߅ߦ࡞࠽ࠣࠪࠬࠪ࡯࠻ࡐࠕޟ‬ዊ⢩૕ߩᓎഀ‫ޠ‬Ṷ⠪)8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫߥߒ9㧚␠ળᵴേ
ਛᎹᢅᐘ㧘⍫㊁(ᣧᎹ)⧐૫㧦
1㧕 ࠨࠗࠛࡦࠬࡢ࡯࡞࠼㧔ጘ㒂⋵㧕੐ᬺ‫ޡ‬㜞ᩞ↢ߩߚ߼ߩ‫ޟ‬ᄞߩߚ߹ߏ‫ࠍޠ‬⢒ߡࠆࠨࠗࠛࡦࠬࠠࡖࡦࡊ‫ޢ‬(ᐔᚑ 18 ᐕᐲ㧦6 ฬ㧘ᐔᚑ 19 ᐕᐲ㧦3 ฬ㧘ᐔᚑ 20 ᐕᐲ㧦3 ฬ)
10㧚ႎ๔ᦠਛᎹᢅᐘ㧦
1㧕 ਛᎹᢅᐘ㧦ዊ⢩૕ࠬ࠻࡟ࠬߦࠃࠆࠞࠬࡄ࡯࠯ᵴᕈൻߦ߅ߌࠆ Bcl-xL ଐሽᕈ೙ᓮᯏ᭴ߩ⸃᣿㧦ᐔᚑ 17
ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ✚᜝ታ❣ႎ๔ᦠ(2006 ᐕ 3 ᦬)
2㧕 ਛᎹᢅᐘ㧘ᣧᎹ૫⧐㧦ᯏ⢻⊛ࠬࠢ࡝࡯࠾ࡦࠣᴺߩ⏕┙ߦࠃࠆዊ⢩૕ࠬ࠻࡟ࠬ೙ᓮ࿃ሶߩ✂⟜⊛ត⚝࡮ᯏ⢻⸃ᨆ㧦ᐔᚑ 17 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ✚᜝ታ❣ႎ๔ᦠ(2006 ᐕ 3 ᦬)
3㧕 ਛᎹᢅᐘ㧘ᣧᎹ૫⧐㧦ᯏ⢻⊛ࠬࠢ࡝࡯࠾ࡦࠣᴺߩ⏕┙ߦࠃࠆዊ⢩૕ࠬ࠻࡟ࠬ೙ᓮ࿃ሶߩ✂⟜⊛ត⚝࡮ᯏ⢻⸃ᨆ㧦ᐔᚑ 18 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ✚᜝ታ❣ႎ๔ᦠ(2007 ᐕ 3 ᦬)
4㧕 ਛᎹᢅᐘ㧦ォ౮࿃ሶ ATF4 ߦࠃࠆࠟࡦࡑ࡯࠮ࠢ࡟࠲࡯࠯ᵴᕈൻߩ೙ᓮᯏ᭴ߩ⸃᣿:ᐔᚑ 19 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄(⪚⧘⎇ⓥ)✚᜝ታ❣ႎ๔ᦠ(2007 ᐕ 3 ᦬)
5㧕 ਛᎹᢅᐘ㧘ᣧᎹ૫⧐㧘દ⮮ᱜᓼ㧦ዊ⢩૕߆ࠄ⊒ାߐࠇࠆ⚦⢩ᱫࠪࠣ࠽࡞ߦࠃࠆࠞࠬࡄ࡯࠯ᵴᕈൻᯏ
᭴ߩ⸃᣿㧧ᐔᚑ 18 ᐕᐲ⥄ὼ⑼ቇ♽⎇ⓥഥᚑ㊄ႎ๔ᦠ㧦1㧙5(2007 ᐕ 5 ᦬)⍫㊁(ᣧᎹ)૫⧐㧦1㧕 ⍫㊁(ᣧᎹ)૫⧐㧦ࠪ࠽ࡊࠬߦ߅ߌࠆዊ⣖ㆇേᄬ⺞∝ේ࿃ಽሶ Caytaxin ߩᯏ⢻⸃ᨆ㧦ᐔᚑ 19 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄(⧯ᚻ⎇ⓥ B)✚᜝ታ❣ႎ๔ᦠ(2007 ᐕ 10 ᦬)11㧚ႎ㆏ߥߒ12㧚⥄Ꮖ⹏ଔ
⹏ଔ
⑼⎇⾌㧔․ቯ㗔ၞ⎇ⓥ㧘⪚⧘⎇ⓥ㧘ၮ⋚⎇ⓥ㧕߅ࠃ߮⽷࿅߆ࠄߩ⎇ⓥ⾌ࠍ₪ᓧߒ㧘ࠝ࡝ࠫ࠽࡞ߥ⎇ⓥࠍᐢߊⴕߞߡ޿ࠆ‫ޕ‬ඳ჻ᓟᦼ⺖⒟߅ࠃ߮ඳ჻೨ᦼ⺖⒟ߩᄢቇ㒮↢ߪ㗅⺞ߦჇ߃ߡ߅ࠅ㧘࿖㓙࡮࿖ౝቇળ
ߩ⊒⴫╬ߦࠃࠅ⋡ᮡࠍ᣿⏕ߦߒߚᢎ⢒ᵴേࠍⴕߞߡ޿ࠆ‫⎇ࠄࠇߎޕ‬ⓥ߅ࠃ߮ᄢቇ㒮ᢎ⢒ߦ㑐ߒߡߩㅴ᝞
⁁ᴫߪ㧘✚ߓߡ㗅⺞ߦ⊒ዷߒߡ޿ࠆ‫ޕ‬㧙㧙⃻⁁ߩ໧㗴ὐ߅ࠃ߮ߘߩኻᔕ╷2008 ᐕ⃻࿷߹ߢ㧘ᧄಽ㊁ߩ⎇ⓥߪ㧘ᢎຬ 2 ฬ㧔ᢎ᝼㧘ഥᢎ㧕ߣᄢቇ㒮↢ 6 ฬ㧔ඳ჻ᓟᦼ⺖⒟㧦4 ฬ㧧ඳ჻⺖⒟೨ᦼ⺖⒟㧦1 ฬ㧧␹⚻ౝ⑼ቇ࡮⠧ᐕቇಽ㊁ක⑼ቇ⺖⒟㧦1 ฬ㧘ᰴᐕᐲ߽ᄢቇ㒮↢ߩ౉ቇࠍ੍ቯߒ
ߡ޿ࠆ㧕ߢ⎇ⓥࠍⴕߞߡ޿ࠆ‫⃻ޕ‬࿷ߩᄢቇ㒮↢ߪ㧘⮎ቇ♽࡮Ꮏቇ♽࡮කቇ♽ߩઁᄢቇ಴り⠪߇ᄙߊ㧘ᧄቇකቇㇱ಴り⠪ߩᧄಽ㊁߳ߩᄢቇ㒮౉ቇߪ੹ߩߣߎࠈߥ޿‫⎇ޕ‬ⓥࠍᐢߊዷ㐿ߔࠆߚ߼ߦߪ㧘᭽‫ߥޘ‬ኾ㐷ಽ㊁಴り⠪ߩ㓸ว㧔Ⲣว㧕૕߇ᔅⷐߢ޽ࠆ‫੹߼ߚߩߘޕ‬ᓟߪઁᄢቇ࡮ઁಽ㊁಴り⠪ߩߺߥࠄߕᧄቇකቇㇱ಴りߩఝ⑲ߥቇ↢ߩ⏕଻ߦദജߒߚ޿‫ޕ‬⑼⎇⾌ขᓧߣᬺ❣㧔⺰ᢥ㧕߇⋧ᒰ㐳ᦼ㑆ߥ޿ 2 ฬߩᢎຬߪ㧘⃻࿷ߩකቇ⎇ⓥߩ਎⇇߆ࠄ߆ߌ㔌ࠇߡ޿ࠆߚ߼㧘ᄢቇ㒮↢ߩᢎ⢒ߣ⎇ⓥߪᢎ᝼ߣഥᢎߩ 2 ฬߢⴕߞߡ޿ࠆ‫ߥ߆⚦ࠅࠃޕ‬ᜰዉߣ਎⇇ߦㅢ↪ߔࠆ⎇ⓥ⠪⢒ᚑࠍല₸ࠃߊ㆐ᚑߔࠆߚ߼ߦ߽ఝ⑲ߥࠬ࠲࠶ࡈߩ⏕଻ߣ⵬ల߇ᦸ߹ࠇࠆ‫ߚ߹ޕ‬㧘ᄢቇ㒮↢ᢎ⢒ߩᤨ㑆⊛ߥలታߣ࿖㓙ൻࠍ⋡ᜰߒ㧘Ფㅳ࿯ᦐᣣߩඦ೨ਛߦ࡜ࡏࡒ࡯࠹ࠖࡦࠣࠍⴕ޿㧘⊒⴫߅ࠃ߮⾰⇼ᔕ╵ࠍోߡ⧷⺆ߢⴕߞߡ޿ࠆ‫੹ޕ‬ᓟᄖ࿖ੱ⎇ⓥ⠪ߣߩ੤ᵹ߿࠮ࡒ࠽࡯ߩలታࠍߪ߆ࠅߚ޿‫ޕ‬⎇ⓥᚑᨐߦ㑐ߒߡ㧘࿖㓙࡮࿖ౝቇળߢᲤᐕ⊒⴫ߒߡ޿ࠆ߇㧘⺰ᢥᢙࠍჇ߿ߔദജ߇ᔅⷐߢ޽ࠆ‫ޕ‬੹ᓟߩዷᦸಽሶ↢‛ቇ߅ࠃ߮⚦⢩↢‛ቇࠍ㚟૶ߒߥ߇ࠄ␹⚻ᄌᕈ∔ᖚߩ∛ᘒ⸃᣿ࠍⴕߞߡ޿ࠆ߇㧘⌕ታߦᚑᨐ߇
⃻ࠇߡ߈ߡ޿ࠆߚ߼㧘ᴦ≮ᴺ㐿⊒߳ߩᔕ↪㧔࠻࡜ࡦࠬ࡟࡯࡚ࠪ࠽࡞࡝ࠨ࡯࠴㧕ࠍ⋡ᜰߒߚ⎇ⓥ߽ขࠅ౉ࠇߚ޿ߣ⠨߃ߡ޿ࠆ‫ޕ‬ᢎ⢒࡮⎇ⓥࠍㅢߒߡ㧘ࠣࡠ࡯ࡃ࡞ߥⷞ㊁ߢ㧘⁛ഃ⊛ߥᕁ⠨߇಴᧪ࠆᄢቇ㒮↢ࠍ⢒ᚑߒߚ޿‫ޕ‬㧙㧙㧔3㧕∛ේ૕೙ᓮಽ㊁1㧚⎇ⓥߩ᭎ⷐ
∛ේ૕೙ᓮಽ㊁ߢߪ∛ේᓸ↢‛ߩಽሶ♽⛔ಽ㘃ߩ⎇ⓥࠍⴕ޿ߥ߇ࠄ㧘⎇ⓥቶߦᤘ๺ 25 ᐕ߆ࠄ 4 ઍߦࠊߚࠆᢎ᝼ߦࠃߞߡ଻ሽߐࠇߡ߈ߚ∛ේ⚦⩶㧘⚂ 2 ਁᩣࠍᚒ߇࿖ߩ⚦⩶ቇ⠪ߦಽ⼑ߔࠆࠨ࡯ࡆࠬࠍⴕߞߡ߈
ߚ‫ޕ‬ᐕ㑆 500 ᩣ߆ࠄ 1000 ᩣࠍಽ⼑ߒ㧘ㆮવቇ⊛ߥหቯଐ㗬ᩣ߽ᐕ㑆ᐔဋ 300 ᩣߦ㆐ߒߡ޿ࠆ‫⩶ޕ‬ᩣߩ♽⛔଻ሽߪ⎇ⓥಽ㊁ߩ⁛⥄ߩᵴേߣߐࠇ㧘ᄢቇߩេഥߪฃߌߡ޿ߥ޿߇㧘࿖ߩ National Bioresource Project
㧔NBRP㧕ߩᡰេࠍ߁ߌߡ⛽ᜬߒߡ޿ࠆ‫ޕ‬
ಽ㊁ߢߪߎࠇࠄߩ⾗↥ࠍ㊀ⷐߥ⎇ⓥၮ⋚ߣߒߡ⎇ⓥᵴേߦ೑↪ߒߡ߈ߚ‫∛ޕ‬ේᓸ↢‛ߩⅣႺࡕ࠾࠲࡯㧘ᗵᨴ∝ߩ✂⟜⊛ߥ⸻ᢿᛛⴚࠍ․⸵ൻߒ㧘⥃ᐥ⸻ᢿߩߺߥࠄߕ㧘ⅣႺᳪᨴߩࡕ࠾࠲࡯㧘⚵ߺᦧ߃૕೑↪ߩ቟ోᕈ⹏ଔᛛⴚ㧘㘩ຠߩᵹㅢࠪࠬ࠹ࡓߩ቟ో▤ℂߥߤߩ᏷ᐢ޿ಽ㊁ߢߩ೑↪ߦะߌߚขࠅ⚵ߺࠍⴕߞߡ޿ࠆ‫ޕ‬↢‛⾗Ḯߪߐࠄߦᓸ↢‛ߩᣂߒ޿♽⛔ಽ㘃ቇߩ᭴▽ߦ⽸₂ߒߡ߅ࠅ㧘ᚒ‫⎇ߩޘ‬ⓥቶ߇਎⇇ߢ໑৻ dnaJㆮવሶߩᄢ㊂࠺࡯࠲ࡌ࡯ࠬࠍ଻᦭ߒߡ߅ࠅ㧘ߎߩ࠺࡯࠲ߢ∛ේᓸ↢‛ߩ⒳ species ߩቯ⟵ߩឭ᩺ߦะߌߚ
Ⓧᭂ⊛ߥ⎇ⓥࠍዷ㐿ߒߡ߈ߚ‫ߚ߹ޕ‬㜞ᐲ∛ේ૕ࠍ଻᦭ߔࠆᢙዋߥ޿⎇ⓥቶߣߒߡୃ჻⺖⒟ߣ㧘ඳ჻⺖⒟ߢ
ߪ∛ේ૕ߩขࠅᛒ޿ߦᾫ✵ߒߚቇ↢ߩ⢒ᚑࠍ߅ߎߥ޿ኾ㐷ኅᢎ⢒ߦዧജߒߡ߈ߚ‫ޕ‬
2㧚ฬ★
ᳯፒቁⴕ
ᢎ᝼㧦
ಎᢎ᝼㧦 ᄢᬮᷡᢥ
↲⇌ବ㇢⻠Ꮷ㧦

Takayuki Ezaki
Kiyofumi Ohkusu
Shunro Kohbata

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
1㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ ⸶㧚శጟ⍮⿷✬㧚⣺ౝࡈࡠ࡯࡜ߩหቯ㧦DNA ࡊࡠ࡯ࡉߣࡊ࡜ࠗࡑ࡯㧦⣺ౝ⚦⩶ߩಽሶ↢‛ቇ⊛ታ㛎ᴺ㧘᧲੩㧦ᣣᧄࡆࡈࠖ࠭ࠬ⩶࠮ࡦ࠲࡯㧧2006 ᐕ㧦15㧙28㧚
2㧕 ᳯፒቁⴕ ⸶㧚శጟ⍮⿷✬㧚⣺ౝߦ↢ᕷߔࠆ⚦⩶ߩ♽⛔㧦㧚⣺ౝ⚦⩶ߩಽሶ↢‛ቇ⊛ታ㛎ᴺ㧘᧲੩㧦ᣣᧄࡆ
ࡈࠖ࠭ࠬ⩶࠮ࡦ࠲࡯㧧2006 ᐕ㧦7㧙14㧚
3㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ ⸶㧚ዊᳰ๺ᒾ✬㧘ⁿ⁚ᷕ✬㧚Emergency ߦኻᔕߢ߈ࠆㄦㅦᬌᩏᴺ㧦⥃ᐥᬌᩏ Yearbook
2006 ⥃ᐥᓸ↢‛ቇ㧔ᗵᨴ∝ቇ㧕ߦ㑐ߔࠆၮ␆⍮⼂㧘᧲੩㧦⥃ᐥ∛ℂೀⴕળ㧧2006 ᐕ㧦145㧙150㧚
4㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ ⸶㧚⑔੗ᰴ⍫㧘㤥Ꮉᷡ⋙ୃ㧦╙ 137 ┨ ࠨ࡞ࡕࡀ࡜∝㧦ࡂ࡝࠰ࡦౝ⑼ቇ ╙ 2 㧘᧲੩㧦ࡔ࠺ࠖࠞ࡞࡮ࠨࠗࠛࡦࠬ࡮ࠗࡦ࠲࡯࠽࡚ࠪ࠽࡞㧧2006 ᐕ㧦49㧙55㧚
5㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ ⸶㧚⑔੗ᰴ⍫㧘㤥Ꮉᷡ⋙ୃ㧦╙ 138 ┨ ⚦⩶ᕈ⿒∯ࡂ࡝࠰ࡦౝ⑼ቇ ╙ 2 㧘᧲੩㧦ࡔ࠺ࠖࠞ࡞࡮ࠨࠗࠛࡦࠬ࡮ࠗࡦ࠲࡯࠽࡚ࠪ࠽࡞㧧2006 ᐕ㧦55㧙59㧚
6㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ ⸶㧦ࡉ࡜࠶ࠢᓸ↢‛ቇ(2 )㧘╙ 9 ┨ ಽ㘃ቇ౉㐷㧦ࡃࠢ࠹࡝ࠕ㧘ਣༀᩣᑼળ␠㧘2007
ᐕ㧦240㧙271㧚
7㧕 ⑔᳗⡸㧘ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ᓸ↢‛ߩ੐ౖ㧦ᕈᗵᨴ∝㧘᧲੩㧦ᦺୖᦠᐫ㧧2008 ᐕ㧦491㧙495㧚
8㧕 ᄢᬮᷡᢥ㧘⑔᳗⡸㧘ᳯፒቁⴕ㧦ᓸ↢‛ߩ੐ౖ㧘࡟ࠫࠝࡀ࡜ᗵᨴ∝㧘Q ᾲ㧘᧲੩㧦ᦺୖᦠᐫ㧧2008 ᐕ㧦480
㧙484㧚
9㧕 ᄢᬮᷡᢥ㧘㊁↰ਁᏗሶ㧘ᳯፒቁⴕ㧦ᓸ↢‛ߩ੐ౖ㧘⣺▤ᗵᨴ∝㧘᧲੩㧦ᦺୖᦠᐫ㧧2008 ᐕ㧦471㧙480㧚⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
1㧕 ᳯፒቁⴕ㧚ਃේ৻ఝ㧚⍹ᴤᳪᨴኻ╷ߦ߅ߌࠆࡃࠗࠝ࡟ࡔ࠵࡯ࠛ࡯࡚ࠪࡦߩ↢ᘒ♽ᓇ㗀⹏ଔᚻᴺ㧘↥ᬺߣⅣႺ 2006 ᐕ㧧4 Ꮞ㧦87㧙90㧚
2㧕 ᳯፒቁⴕ㧚ᄢᬮᷡᢥ.ᣂߒ޿⥃ᐥᬌᩏ࡮ᧂ᧪ߩ⥃ᐥᬌᩏ ᗵᨴ∝ᬌᩏ DNA ࠴࠶ࡊࠍ↪޿ߚ⚦⩶ߩหቯ㧘ᬌᩏߣᛛⴚ 2006 ᐕ㧧34 Ꮞ㧦1303㧙1307.
3㧕 ᳯፒቁⴕ㧚╙ 1 ࿁ ᡷቯ߇੍ቯߐࠇߡ޿ࠆᗵᨴ∝ᴺߣ∛ේ૕ߩ଻ሽಽ⼑㧘ㅪタ‫ޟ‬ᓸ↢‛ߩ቟ో▤ℂ‫ޠ‬
Microbiol.Cult.Coll. 2006 ᐕ㧧4 Ꮞ㧦125㧙128.
4㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ᗵᨴ∝⸻ᢿߩㄦㅦൻࠍ߼ߑߒߡ ㆮવሶ߅ࠃ߮ࠪࠣ࠽࡞Ⴧ᏷ᴺ ⥃ᐥߣᓸ↢‛
2007 ᐕ㧧34 Ꮞ㧦459㧙478.
5㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ᗵᨴ∝⸻ᢿߩㄦㅦൻࠍ߼ߑߒߡ Ⱟశࡑࠗࠢࡠࡆ࡯࠭ࠕ࡟ࠗ ⥃ᐥߣᓸ↢‛ 2007
ᐕ㧧34 Ꮞ㧦482㧙486.
6㧕 ᵄᄙብᐘ㧘ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ᗵᨴ∝⸻ᢿߩㄦㅦൻࠍ߼ߑߒߡ ࠪ࡯ࠢࠛࡦࠬ⸃ᨆ ⥃ᐥߣᓸ↢‛ 2007
ᐕ㧧34 Ꮞ㧦487㧙492.
7㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦∛ේᕈ⚦⩶ߩᱜᑼ⊒⴫⩶ฬ࡝ࠬ࠻ ᣣᧄ⥃ᐥᓸ↢‛ቇ㔀⹹ 2007 ᐕ㧧17 Ꮞ㧦53㧙
108.
8㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ᗵᨴ∝ߩ⸻ᢿ ㆮવሶቇ⊛⸻ᢿᴺ ᣣᧄ⥃ᐥ 65 Ⴧೀภ 2007 ᐕ㧧2 Ꮞ㧦199㧙207.

㧙㧙9㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦ዩ〝ᗵᨴ∝ߩㆮવሶᬌᩏ ⥃ᐥᬌᩏ 2007 ᐕ㧧51 Ꮞ㧦159㧙163.
10㧕 ᳯፒቁⴕ㧦ᓸ↢‛ߩෂ㒾ᐲಽ㘃. ⥃ᐥߣᓸ↢‛ 2008 ᐕ㧧35 Ꮞ㧦279㧙292.
11㧕 ᄢᬮᷡᢥ㧦ᗵᨴ∝⸻ᢿߦ߅ߌࠆㆮવሶ⸃ᨆᛛⴚߩㆡᔕ ᣣᧄ⥃ᐥᓸ↢‛ቇળ⹹ 2008 ᐕ㧧18 Ꮞ㧦163㧙176.
12㧕 ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧦ㆮવሶᬌᩏߦࠃࠆ᛫㉄⩶ᗵᨴ∝ߩㄦㅦ⸻ᢿ ⚿ᩭ 2008 ᐕ㧧83 Ꮞ㧦684㧙688.
✚⺑㧔᰷ᢥ㧕
ߥߒේ⪺㧔๺ᢥ㧕
1㧕 Ⓑ⷗↱♿ሶ㧘⍹๺↰⒤ᒾ㧘ᷓᴛජ⛗㧘ᄢᬮᷡᢥ㧘⪉ᧁߪࠆ߆㧘ᱞ↰⚩ᳯ㧘ᴡ㊁㓁৻㧚㜑ᶧᬌ૕ߦኻߔࠆ⢖Ἳ⃿⩶ዩਛ᛫ේㄦㅦᬌ಴ࠠ࠶࠻ߩ૶↪߇⸻ᢿ਄᦭↪ߢ޽ߞߚ⢖Ἳ⃿⩶ᕈ㜑⤑Ἳߩ 1 ଀㧘ዊఽᗵᨴ఺∉
2006 ᐕ㧧18 Ꮞ㧦405㧙409㧚
2㧕 ቟ጟ⍾❱㧘ዊ᫾ᱜ㆏㧘⍫㊁ਭሶ㧘๺↰㗅ሶ㧘ኹፉብ㧘ጟᧄౖሶ㧘⣁ᧄᐘᄦ㧘Ḵ਄㓷ผ㧘᫪㓷⟤㧘ᅏ૑ᝰሶ㧘ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧘㑆ች⚩৻㇢㧦㥦ຜ༄ౝⷞ㏜ߩᵞᵺ࡮ᶖᲥߩታᘒߣᗵᨴ੍㒐╷ߩᬌ⸛㧘ⅣႺᗵᨴ 2006
ᐕ㧧21 Ꮞ㧦263㧙268.
3㧕 ㊁᧛෹Ꮧሶ㧘౷↰ᐘᏗ㧘ᩊ↰㓷ᒾ㧘㕍ᩉື㧘⦼ᧁᤩᒾ㧘⣁ဈߜ߭ࠈ㧘ᄢᬮᷡᢥ㧘ᷡ᳓ብ㧦ᄙ⊒ᕈ⊹ਅ࡮╭⤥≌ࠍ๒ߒߚࡁࠞ࡞ࠫࠕ∝ ᣣᧄ⊹⤏⑼ቇળ㔀⹹ 2007 ᐕ㧧117 Ꮞ㧦1745㧙1751.
4㧕 ⷗਄⵨⟤ሶ㧘ᄢႦ༑ੱ㧘᧖ᶆ⑲ሶ㧘ᄢᬮᷡᢥ㧘ᳯፒቁⴕ㧘㗇᳗⦟㧘ၳਯౝ⑲ੑ㧘ฎᎹᕺ৻㧘ᱞ↰੩ሶ㧦
Anaerobiospirillum succiniciproducens ߦࠃࠆᢌⴊ∝ߩ 1 ଀ ⥃ᐥ∛ℂ 2007 ᐕ㧧55 Ꮞ㧦930㧙935.
5㧕 ખ㊁ᢕሶ㧘᦭ᧄ෹ቄሶ㧘Ꮏ⮮ౖઍ㧘ᤊ㊁⋥㧘ᄢᬮᷡᢥ㧦2 ࡩᚲߦ㗖ㇱ⤥≌ࠍᒻᚑߒߚ₀߭ߞ߆߈∛ߩዊఽ଀㧘ᣣᧄ⡊㥦ຜ༄⑼ᗵᨴ∝⎇ⓥળળ⹹ 2007 ᐕ㧧25 Ꮞ㧦157㧙160.
6㧕 ᧶ᷨ⾆ᵗ㧘ᄢႦ༑ੱ㧘ᄢᬮᷡᢥ㧘ਛ⷏੩ሶ㧘ቝ૒⟤๺↵㧘ᳯፒቁⴕ㧦Corynebacterium durum ߇⿠Ἳ⩶ߣߒߡ⇼ࠊࠇߚ⢖Ἳߩ 1 ଀㧘ᣣᧄ⥃ᐥᓸ↢‛ቇ㔀⹹ 2007 ᐕ㧧17 Ꮞ㧦1㧙7.
7㧕 㐳Ỉᥓ૫ሶ㧘ᷦ⼱૫⋥㧘᳓⼱㓁ሶ㧘ᷡፉ⌀ℂሶ㧘ᄢᬮᷡᢥ㧦㜞㦂⠪ߦ↢ߓߚ዆Ᏹᕈ⁤≙ߩ 2 ଀㧘⥃ᐥ⊹⤏⑼ 2007 ᐕ㧧61 Ꮞ㧦235㧙238.
8㧕 ട⾐⼱⌀⿠ሶ㧘㜞ᯅඳਯ㧘ਛ㊁⑲ᤘ㧘ᄢᬮᷡᢥ㧦ࡁࠞ࡞ࠫࠕߦࠃࠆᄙ⊒ᕈ╭⡺ౝ⤥≌ߩ 1 ଀ ⷏ᣣᧄ⊹⤏⑼ 2008 ᐕ㧧70 Ꮞ㧦286㧙291.
9㧕 ਃᶆ૒⍮ሶ㧘ᷰᥓਭ㧘቟↰◊ᔒ㧘᫪ᣧ⧣㧘የ᩟㓉㧘⇌ਛቬඳ㧘ᄢᬮᷡᢥ㧦ⴊᶧၭ㙃 10 ᣣ⋡ߦᬌ಴ߒᓧߚ
Helicobacter cinaedi ᢌⴊ∝ߩ 1 ଀ ർᶏ㆏⥃ᐥᬌᩏᛛᏧ⹹ 2008 ᐕ㧧6 Ꮞ㧦42㧙45.
10㧕 ㋈ᧁᥓሶ㧘⨹Ꮉᥓ૫ሶ㧘ᷦ⼱૫⋥㧘ᷡፉ⌀ℂሶ㧘ᵻ㊁⵨ሶ㧘ᄢᬮᷡᢥ㧦“M. ulcerans subsp. shinshuense”
ߦࠃࠆ⊹⤏ẩ≌ ⊹⤏∛⸻≮ 2008 ᐕ㧧30 Ꮞ㧦145㧙148.
11㧕 ⍹๺↰⒤ᒾ㧘⪉ᧁߪࠆ߆㧘ᷰㆻᱜᴦ㧘ᄢᬮᷡᢥ㧘ᴡ㊁㓁৻㧦BCG ⩶ߣࡅ࠻ဳ⚿ᩭ⩶ߩ㐓೎ߦ PCR ᴺ߇᦭
↪ߢ޽ߞߚ⢷ㇱ⊹ਅ⤥≌࡮⡻㛽㛽㜑Ἳߩ 1 ዊఽ଀ ᗵᨴ∝ቇ㔀⹹ 2008 ᐕ㧧82 Ꮞ㧦30㧙33.
12㧕 ᫪ᣧ⧣㧘ᷰᥓਭ㧘቟↰◊ᔒ㧘ਃᶆ૒⍮ሶ㧘የ᩟㓉㧘⇌ਛቬඳ㧘ᄢᬮᷡᢥ㧦Solobacterium moorei ᢌⴊ∝ߩ
1 ଀㧦ᧄ㇌ೋߩႎ๔∝଀ߣ⩶ᩣߩ․ᓽߦߟ޿ߡ ᣣᧄ⥃ᐥᓸ↢‛ቇ㔀⹹ 2008 ᐕ㧧18 Ꮞ㧦236㧙243.
ේ⪺㧔᰷ᢥ㧕
1㧕 Huang X, Xu H, Sha M.M, Zhao L, Ohkusu K, Kawamura Y, Ezaki T. Virulence-defective strains ofSalmonella enterica serover Typhi as candidates for education at level 2 facilites. Microbiol Immunol.
2006;50:273-279.
2㧕 Otsuka Y, Ohkusu K, Kawamura Y, Baba S, Ezaki T, Kimura S. Emergence of multidrug-resistant
Corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with
underlying diseases. Diagnostic Microbiol Infect Dis. 2006;54:109-114.
3㧕 Fukasawa C, Ohkusu K, Sanayama, Y, Yasufuku K, Ishiwada N, Ezaki T, Kohno Y. A mixed bacterial
infection of bronchogenic lung cyst diagnosed by polymerase chain reaction. J Med Microbiol
2006;55:791-794.
4㧕 Itoh Y, Kawamura Y, Kasai H, Shah MM, Nhung PH, Yamada M, Sun X, Koyama, T, Ohkusu K, Ezaki
T. dnaJ and gyrB gene sequence relationship among species and strains of the genus Streptococcus.
Syst. Applied Microbiol. 2006;29:368-374.
5㧕 Maski T, Ohkusu K, Hata H, Fujiwara N, Iihara H, Noda MY, Nhung PH, Hayashi M, Asano Y,
Kawamura Y, Ezaki T. Mycobacterium kumamotonense sp. nov. and the first isolation report of
Mycobacterium arupense in Japan: novel slowly growing, nonchromognenic clinical isolates related to
Mycobacterium terrae complex. Microbiol Immunol. 2006;50:889-897.
6㧕 Iihara H, Suzuki T, Kawamura Y, Ohkusu K, Inoue Y, Zhang W, Shah MM, Katagiri Y, Ohashi Y, Ezaki
T. Emerging multiple mutations and high-level fluoroquinolone resistance in methicillin-resistant
Staphylococcus aureus isolated from ocular infections. Diagnostic Microbiol Infect Dis.
2006;56:297-303.
7㧕 Ichimura S, Nagano M, Ito N, Shimojima M, Egashira T, Miyamoto C, Ohkusu K, Ezaki T. Evaluationof the Invader assay with the BACTEC MGIT 960 system for prompt isolation and identification of
Mycobacteria from clinical specimens. J Clin Microbiol. 2007;45:3316-3322.
8㧕 Suzuki T, Iihara H, Uno T, Hara Y, Ohkusu K, Hata H, Shudo M, Ohashi Y. Suture-related keratidis
caused by Corynebacterium macginleyi. J Clin Microbiol. 2007;45:3833-3836.
9㧕 Funato M, Kaneko H, Matsui E, Teramoto T, Kato Z, Fukao T, Ohkusu K, Kondo N. Refractory㧙㧙

IF 1.440

IF 2.316

IF 2.484

IF 2.456

IF 1.440

IF 2.316

IF 3.445
IF 3.445

osteomyelitis caused by bacille Calmette-Guérin vaccination: a case report. Diag Microbiol Infect Dis.
2007;59:89-91.
IF
10㧕 Sakamoto M, Ohkusu K, Masaki T, Kato H, Ezaki T, Benno Y. Prevotella pleuritidis sp. nov., isolated
from pleural fluid. International J Systematic Evolutionary Microbiol. 2007;57:1725-1728.
IF
11㧕 Iihara H, Niwa T, Shah MM, Nhung PH, Sun XS, Hayashi M, Ohkusu K, Itoh Y, Makino S, Ezaki T.
Rapid multiplex immunofluorescent assay to detect antibodies against Burkholderia pseudomallei andtaxonomically closely related nonfermenters. Jpn J Infect Dis. 2007;60:230-234.
IF
12㧕 Noda YM, Ohkusu K, Hata H, Shah MM, Nhung PH, Sun X, Hayashi M, Ezaki T. Mycobacterium
species identification - A new approach via dnaJ gene sequencing. Systematic Applied Microbiol.
2007;30:453-462.
IF
13㧕 Nhung PH, Ohkusu K, Miyasaka J, Sun XS, Ezaki T. Rapid and specific identification of 5 humanpathogenic Vibrio species by multiplex polymerase chain reaction targeted to dnaJ gene. Diag
Microbiol Infect Dis. 2007;59:271-275.
IF
14㧕 Nhung PH, Hata H, Ohkusu K, Noda M, Shah MM, Goto K, Ezaki T. Novel phylogenetic marker dnaJand DNA-DNA hybridization for clarifying interrelationships among the genus Aeromonas.
International J Systematic Evolutionary Microbiol. 2007;57:1232-1237.
IF
15㧕 Nhung PH, Ohkusu K, Mishima N, Noda M, Shah MM, Sun X, Hayashi M, Ezaki T. Phylogeny andspecies identification of the family Enterobacteriaceae based on dnaJ sequences. Diag Microbiol InfectDis. 2007;58:153-161.
IF
16㧕 Nureki S, Miyazaki E, Matsuno O, Takenaka R, Ando M, Kumamoto T, Nakano, T, Ohkusu K, Ezaki T.
Corynebacterium ulcerans infection of the lung mimicking the histology of Churg-Strauss syndrome.
Chest. 2007;131:1237-1239.
IF
17㧕 Nhung PH, Shah MM, Ohkusu K, Noda M, Hata H, Sun X, Iihara H, Goto K, Masaki T, Ezaki T. dnaJ
gene as a novel phylogenetic marker for identification of Vibrio species. Systematic Applied Microbiol.
2007;30:309-315.
IF18㧕 Huang X, Xu H, Sun X, Ohkusu K, Kawamura Y, Ezaki T. Genome-wide scan of the gene expression
kinetics of Salmonella enterica serovar Typhi during hyperosmotic stress. Int J Mol Sci.
2007;8:116-135.
IF
19㧕 Masue N, Deguchi T, Yokoi S, Yamada T, Ohkusu K, Ezaki T. System for simultaneous detection of 16
pathogens related to urethritis to diagnose mixed infection. Int J Urology. 2007;14:39-42.
IF
20㧕 Kitamura T, Kawamura Y, Ohkusu K, Masaki T, Iwashita H, Sawa T, Fujii S, Okamoto T, Akaike T.
Helicobacter cinaedi cellutitis and bacteremia in immunocompetent hosts after orthopedic surgery. J
Clin Microbiol. 2007;45:31-38.
IF
21㧕 Shah MM, Iihara H, Noda M, Sun X, Nhung PH, Ohkusu K, Kawamura Y, Ezaki T. dnaJ genesequence-based assay for species identification and phylogenetic grouping in the genus Staphylococcus.
Int J Systematic Evolutionary Microbiol. 2007;57:25-30.
IF
22㧕 Kuroki H, Miyamoto H, Fukuda K, Iihara H, Kawamura Y, Ogawa M, Wang Y, Ezaki T, Taniguchi H.
Legionella impletisoli sp. nov. and Legionella yabuuchiae sp. nov., isolated from soils contaminatedwith industrial wastes in Japan. Systematic Applied Microbiol. 2007;30:273-279.
IF
23㧕 Ohtsuki,R., Kawamoto,K., Kato,Y., Sha, M.M., Ezaki,T., and Makino,S-I. Rapid detection of Brucellaspp. By the loop-mediated isothermal amplification method. J Appl Microbiol. 2008;1-7.
IF
24㧕 Ohno T, Kishimoto W, Chihara D, Sakamoto T, Miyamoto K, Takeoka T, Tsuji M, Kida K, Ohkusu K,
Ezaki T. First case report of sepsis caused by Mycobacterium wolinskyi in chronic myelogenous
leukemia. Diag Microbiol Infect Dis. 2008;62:433-436.
IF
25㧕 Yamamoto Y, Shioshita K, Takazono T, Seki M, Izumikawa K, Kakeya H, Yanagihara K, Tashiro T,
Otsuka Y, Ohkusu K, Kohno S. An autopsy case of Erysipelothrix rhusiopathiae endocarditis. Inter
Med. 2008;47:1437-1440.

2.553
2.662

0.910

2.037

2.553

2.662

2.553

3.924

2.037

0.679
0.691

3.445

2.662

2.037
2.501

2.553

4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛ᄖㇱ⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦ᳯፒቁⴕ㧘⎇ⓥಽᜂ⠪㧦ᴡ᧛ᅢ┨㧘ᄢᬮᷡᢥ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦
⚦⩶ߩᣂߒ޿⩶⒳ߩቯ⟵ࠍ૞ᚑߔࠆߚ߼ߩᄙဳㆮવሶ࠺࡯࠲ࡌ࡯ࠬߩ૞ᚑ㧧ᐔᚑ 16㧙18 ᐕᐲ㧧
14,200 ජ౞(5,600㧦4,300㧦4,300 ජ౞)
2㧕 ⎇ⓥઍ⴫⠪㧦ᳯፒቁⴕ㧘⎇ⓥಽᜂ⠪㧦ᴡ᧛ᅢ┨㧘ᄢᬮᷡᢥ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦
⚦⩶ߩᣂߒ޿⩶⒳ߩቯ⟵ࠍ૞ᚑߔࠆߚ߼ߩᄙဳㆮવሶ࠺࡯࠲ࡌ࡯ࠬߩ૞ᚑ㧧ᐔᚑ 16㧙18 ᐕᐲ㧧
14,200 ජ౞(5,600㧦4,300㧦4,300 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦’㊁ჽ৻㧔Ꮺᐢ⇓↥ᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌
⵬ഥ㊄㧦↢‛࠹ࡠߦ૶↪ߐࠇࠆน⢻ᕈߩ㜞޿⚦⩶࡮࠙ࠖ࡞ࠬ╬ߦࠃࠆᗵᨴ∝ߩ⬧ᑧ㒐ᱛ‫੍ޔ‬㒐‫⸻ޔ‬ᢿ‫ޔ‬ᴦ≮ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 15㧙18 ᐕᐲ㧧16,500 ජ౞(5,600㧦4,300㧦4,300㧦2,300 ජ౞)
4㧕 ⎇ⓥઍ⴫⠪㧦ศ↰⌀৻㧔਻Ꮊᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㧙㧙㊄㧦⚦⩶ᕈ⣺▤ᗵᨴ∝ߩ∛ᘒ⸃ᨆ࡮⸻ᢿ࡮ᴦ≮࡮∉ቇ࡮੍㒐ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 18 ᐕᐲ㧧500 ජ౞5㧕 ⎇ⓥઍ⴫⠪㧦’㊁ჽ৻㧔Ꮺᐢ⇓↥ᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌
⵬ഥ㊄㧦↢‛࠹ࡠߦ૶↪ߐࠇࠆน⢻ᕈߩ㜞޿⚦⩶࡮࠙ࠖ࡞ࠬ╬ߦࠃࠆᗵᨴ∝ߩ⬧ᑧ㒐ᱛ‫੍ޔ‬㒐‫⸻ޔ‬ᢿ‫ޔ‬ᴦ≮ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 19 ᐕᐲ㧧2,000 ජ౞6㧕 ⎇ⓥઍ⴫⠪㧦ศ↰⌀৻㧔਻Ꮊᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧦⚦⩶ᕈ⣺▤ᗵᨴ∝ߩ∛ᘒ⸃ᨆߣߘߩᔕ↪⊛⎇ⓥ㧧ᐔᚑ 19 ᐕᐲ㧧1,080 ජ౞7㧕 ⎇ⓥઍ⴫⠪㧦ᳯፒቁⴕ㧘⎇ⓥಽᜂ⠪㧦ᄢᬮᷡᢥ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦ⵙቯᆔຬળߦ㜞ᐲ∛ේ૕ߩᣂಽ㘃ᴺࠍឭ᩺ߔࠆߚ߼ߩᩮ᜚ߣߔࠆㆮવᖱႎߩ෼㓸㧧ᐔᚑ 20㧙24 ᐕᐲ㧧15,440
ජ౞(6,240㧦2,800㧦2,100㧦2,200㧦2,100 ජ౞)
8㧕 ⎇ⓥઍ⴫⠪㧦’㊁ჽ৻㧔Ꮺᐢ⇓↥ᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌
⵬ഥ㊄㧦࠹ࡠߩน⢻ᕈߩ޽ࠆ∛ේ૕╬ߩᣧᦼᬌ⍮࡮ㄦㅦ⸻ᢿᴺߩ㐿⊒ߣߘߩ⹏ଔᴺߩ⏕┙ߦ㑐ࠊࠆ
⎇ⓥ㧧ᐔᚑ 20 ᐕᐲ㧧3,000 ජ౞9㧕 ⎇ⓥઍ⴫⠪㧦ᳯፒቁⴕ㧘⎇ⓥಽᜂ⠪㧦ᄢᬮᷡᢥ㧧࿾ၞࠗࡁࡌ࡯࡚ࠪࡦഃ಴⎇ⓥ㐿⊒੐ᬺ㧔▤ℂᴺੱ㧦ᩣᑼળ␠࠻࡜ࠬ࠻㧕㧦ᗵᨴ∝ߩ∛ᘒ೎‫ޔ‬ㄦㅦᄙ㗄⋡⸻ᢿࠪࠬ࠹ࡓߩ㐿⊒㧙⸻ᢿᣇᴺ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧3,499,650 ౞
10㧕 ⎇ⓥઍ⴫⠪㧦ᳯፒቁⴕ㧘⎇ⓥಽᜂ⠪㧦ᄢᬮᷡᢥ㧧࿾ၞࠗࡁࡌ࡯࡚ࠪࡦഃ಴⎇ⓥ㐿⊒੐ᬺ㧔▤ℂᴺੱ㧦․ቯ㕖༡೑ᵴേᴺੱ ⾗Ḯ࡝ࠨࠗࠢ࡞ࠪࠬ࠹ࡓ࠮ࡦ࠲࡯㧕㧦PCR ߣࡊࡠ࡯ࡉ࿕ቯၮ᧼ࠍ↪޿ߚ◲ᤃㄦㅦᓸ↢‛ᬌᩏᛛⴚߩ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧11,660,250 ౞
11㧕 ⎇ⓥઍ⴫⠪㧦ศ↰⌀৻㧔਻Ꮊᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧦ᗵᨴ∝ߩ∛ᘒ೎‫ޔ‬ㄦㅦᄙ㗄⋡⸻ᢿࠪࠬ࠹ࡓߩ㐿⊒㧙⸻ᢿᣇᴺ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧950 ජ౞
12㧕 ⎇ⓥઍ⴫⠪㧦’㊁ჽ৻㧔Ꮺᐢ⇓↥ᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ᳯፒቁⴕ㧔ጘ㒂ᄢቇ㧕㧧ᢥㇱ⑼ቇ⋭ ㇺᏒࠛ࡝ࠕ↥ቇቭㅪ៤ផㅴ੐ᬺ㧦㘩ߩⶄว⊛ᯏ⢻ᕈ࡮㜞ᐲߥ቟ోᕈߦଥࠆ㑐ㅪᛛⴚߩน⢻ᕈ⎇ⓥ෸߮⹜㛎࡮⺞ᩏ㧧ᐔᚑ 20 ᐕᐲ㧧5,000 ජ౞
2㧕ฃ⸤⎇ⓥ1㧕 ᳯፒቁⴕ㧦ᶖ⥇ലᨐߣᲕ⩶૞↪ߩ޽ࠆ቟ቯൻੑ㉄ൻႮ⚛ߩⅣႺ೑↪ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 18 ᐕᐲ㧧800
ජ౞㧦(᦭)ጘ㒂ⴡ᧚
2㧕 ᳯፒቁⴕ㧦ᓸ↢‛ߩ㐿᡼♽೑↪ߦଥࠆ⹏ଔᚻᴺ╷ቯߩߚ߼ߩၮ␆⺞ᩏ㧧ᐔᚑ 18 ᐕᐲ㧧4,500 ජ౞㧦(⽷)ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯දળ
3㧕 ᳯፒቁⴕ㧦∛ේᓸ↢‛ㆮવ⾗Ḯߩ෼㓸࡮଻ሽ࡮ឭଏ૕೙ߩ᭴▽㧧ᐔᚑ 14㧙18 ᐕᐲ㧧24,592 ජ౞(7,000㧦
7,000㧦4,762㧦3,130㧦2,700 ජ౞)㧦㧔⁛㧕⑼ቇᛛⴚᝄ⥝ᯏ᭴
4㧕 ᳯፒቁⴕ㧦ࡑࠗࠢࡠࠕ࡟ࠗࠍ↪޿ߚⅣႺਛߩ∛ේᓸ↢‛╬ߩࡕ࠾࠲࡝ࡦࠣ㧧ᐔᚑ 15㧙18 ᐕᐲ㧧48,041
ජ౞(9,114㧦12,631㧦12,600㧦13,696 ජ౞)㧦(⽷)ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯දળ
5㧕 ᳯፒቁⴕ㧦๭ๆེ♽࠙ࠖ࡞ࠬᬌ಴↪ DNA ࠴࠶ࡊߩ㐿⊒⎇ⓥ㧙࠙ࠖ࡞ࠬࠬࠢ࡝࡯࠾ࡦࠣ↪ DNA ࠴࠶ࡊߩᬌ⸛㧙㧧ᐔᚑ 17㧙18 ᐕᐲ㧧1,000 ජ౞㧔500㧦500 ජ౞㧕㧦ጘ㒂⋵଻ஜⅣႺ⎇ⓥᚲ
6㧕 ᳯፒቁⴕ㧦ࡆ࡯࠭ࠕ࡟ࠗߢᄙ⒳㘃ߩ∛ේ૕ߩㆮવሶࠍ⸃ᨆߒᗵᨴ∝ࠍ⸻ᢿߔࠆᣇᴺߩᛛⴚ㐿⊒㧧ᐔᚑ 18㧙19 ᐕᐲ㧧3,000 ජ౞㧦ࠛ࡯ࠛࡓࠕ࡯࡞ࢃ
7㧕 ᳯፒቁⴕ㧦ࡆ࡯࠭ࠕ࡟ࠗߢᄙ⒳㘃ߩ∛ේ૕ߩㆮવሶࠍ⸃ᨆߒᗵᨴ∝ࠍ⸻ᢿߔࠆᣇᴺߩᛛⴚ㐿⊒㧧ᐔᚑ 19㧙20 ᐕᐲ㧧3,000 ජ౞㧦ࠛ࡯ࠛࡓࠕ࡯࡞ࢃ
8㧕 ᳯፒቁⴕ㧦ᓸ↢‛ߩ㐿᡼♽೑↪ߦଥࠆ⹏ଔᚻᴺ╷ቯߩߚ߼ߩၮ␆⺞ᩏ㧧ᐔᚑ 19 ᐕᐲ㧧4,000 ජ౞㧦(⽷)ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯දળ㧔⁛㧕
9㧕 ᳯፒቁⴕ㧦∛ේᓸ↢‛ㆮવ⾗Ḯߩ෼㓸࡮଻ሽ࡮ឭଏ૕೙ߩ᭴▽㧧ᐔᚑ 19 ᐕᐲ㧧42,833 ජ౞㧦⑼ቇᛛⴚᝄ⥝ᯏ᭴10㧕 ᳯፒቁⴕ㧦㢚ෆ᛫૕ᛛⴚࠍ↪޿ߚฦ⒳∛ේ૕ߩᬌ಴෸߮ᗵᨴ੍㒐㧧ᐔᚑ 19 ᐕᐲ㧧819 ජ౞㧦㧔ᩣ㧕ࠗࡓࠫࠚࡦ
11㧕 ᳯፒቁⴕ㧦๭ๆེ♽࠙ࠖ࡞ࠬᬌ಴↪ DNA ࠴࠶ࡊߩ㐿⊒⎇ⓥ㧙࠙ࠖ࡞ࠬࠬࠢ࡝࡯࠾ࡦࠣ↪ DNA ࠴࠶ࡊߩᬌ⸛㧙㧧ᐔᚑ 19 ᐕᐲ㧧500 ජ౞㧦ጘ㒂⋵଻ஜⅣႺ⎇ⓥᚲ
12㧕 ᳯፒቁⴕ㧦⣺ౝ⚦⩶ߩ dnaJ ㆮવሶႮၮ㈩೉ߩ᳿ቯ෸߮⹏ଔ㧧ᐔᚑ 19 ᐕᐲ㧧1,882 ජ౞㧦㧔⁛㧕⵾ຠ⹏ଔᛛⴚၮ⋚ᯏ᭴13㧕 ᳯፒቁⴕ㧦᛫㉄⩶ㆮવሶหቯࡊࡠ࡯ࡉߩ․⇣ᕈߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 19 ᐕᐲ㧧3,000 ජ౞㧦᧲ᵗ⚜❣
㧔ᩣ㧕14㧕 ᳯፒቁⴕ㧦∛ේᓸ↢‛ㆮવ⾗Ḯߩ෼㓸࡮଻ሽ࡮ឭଏ૕೙ߩ᭴▽㧧ᐔᚑ 20 ᐕᐲ㧧3,900 ජ౞㧦㧔⁛㧕⑼ቇᛛⴚᝄ⥝ᯏ᭴㧙㧙

15㧕 ᳯፒቁⴕ㧦ⅣႺਛߩ∛ේᕈᓸ↢‛ߩᄌേࠍᛠីߔࠆߚ߼ߩᚻᴺߦ㑐ߔࠆၮ␆⺞ᩏ㧧ᐔᚑ 20 ᐕᐲ㧧
5,250 ජ౞㧦(⽷)ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯දળ
16㧕 ᳯፒቁⴕ㧦ᶷ⩶߅ࠃ߮ࠢ࡜ࡒࠫࠕหቯࡊࡠ࡯ࡉߩ․⇣ᕈߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 20 ᐕᐲ㧧2,000 ජ౞㧦᧲ᵗ⚜❣㧔ᩣ㧕
3㧕౒ห⎇ⓥ1㧕 ᳯፒቁⴕ㧦ੱ⇓౒ㅢ∛ේ૕ߩ଻⩶⁁ᴫࠍࠬࠢ࡝࡯࠾ࡦࠣߔࠆᬌᩏᴺߩ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧3,000 ජ౞㧦㧔ᩣ㧕ࠫ࡯ࠛ࡯ࡆ࡯
2㧕 ᳯፒቁⴕ㧦ㄦㅦ⢖Ἳ⸻ᢿࠍ⋡⊛ߣߒߚࠞ࠮࠶࠻ᑼ◲ᤃ⸻ᢿᯏེߩ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧150 ජ౞㧦᦭㒢ળ␠ ጊญ࠹ࠖ࡯࡮ࠛ࡞࡮ࠝ࡯
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫ
1㧕 ᳯፒቁⴕ㧦ࠝ࡝ࠧ࠿ࠢ࡟ࠝ࠴࠼࠮࠶࠻෸߮ߘߩ೑↪ᴺ(․⸵)㧧ᐔᚑ 18 ᐕᐲ
2㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦DnaJ ㈩೉ࠍ೑↪ߒߚ⚦⩶ߩᬌ಴࡮หቯᣇᴺ(․⸵)㧧ᐔᚑ 18 ᐕᐲ
3㧕 ᳯፒቁⴕ㧦∛ේᓸ↢‛ߩ࠲࡯ࠥ࠶࠻ᩭ㉄ Ⴧ᏷ᴺ෸߮Ⴧ᏷↪ࡊ࡜ࠗࡑ࡯ ᷙว‛(G1-H17-64)㧧ᐔᚑ
19 ᐕᐲ
4㧕 ᳯፒቁⴕ㧦↢⩶ߩ㜞ᗵᐲㆮવሶᬌᩏᴺ(G1-H19-9)㧧ᐔᚑ 19 ᐕᐲ
5㧕 ᳯፒቁⴕ㧦DnaJ ㆮવሶࠍ೑↪ߒߚ⚦⩶ߩᬌ಴߅ࠃ߮ߘߩ೑↪(G1-H17-64)㧧ᐔᚑ 19 ᐕᐲ
6㧚ቇળᵴേ
1㧕ቇળᓎຬᳯፒቁⴕ㧦
1㧕 ᣣᧄ⚦⩶ቇળ⹏⼏ᆔຬ(㨪⃻࿷)2㧕 ᣣᧄ⥃ᐥᓸ↢‛ቇળ೽ળ㐳(㨪⃻࿷)3㧕 ᣣᧄᗵᨴ∝ቇળ⹏⼏ຬ(㨪⃻࿷)4㧕 ᣣᧄⅣႺᗵᨴቇળ⹏⼏ຬ(㨪⃻࿷)5㧕 ࿖㓙ᓸ↢‛ㅪ⋖ National Organizing committee(2007 ᐕ㨪⃻࿷)㧘
ⵙቯᆔຬ Judicial committee(㨪⃻࿷)㧘
๮ฬዊᆔຬ Subcommittee of Staphylococcal and Streptococcal nomenclature(㨪⃻࿷)6㧕 ᣣᧄᓸ↢‛⾗Ḯቇળℂ੐(㨪⃻࿷)7㧕 ᣣᧄ♽⛔ಽ㘃⎇ⓥળળ㐳(㨪⃻࿷)ᄢᬮᷡᢥ㧦1㧕 ᣣᧄ⥃ᐥᓸ↢‛ቇળᐙ੐⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ⹏⼏ຬ(㨪⃻࿷)3㧕 ⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળᐙ੐(㨪⃻࿷)2㧕ቇળ㐿௅
ߥߒ
3㧕ቇⴚ㔀⹹
ߥߒ
7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳ᳯፒቁⴕ㧦
1㧕 ╙ 45 ࿁ᣣᧄ↢૕කᎿቇળᄢળ(ᐔᚑ 18 ᐕ 5 ᦬㧘ඳᄙ㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ቝቮ⦁ౝߢߩᗵᨴ∝⸻ᢿ෸߮
⦁ౝ⩶ฌߩࡕ࠾࠲࡯ࠪࠬ࠹ࡓ‫ޠ‬Ṷ⠪)
2㧕 ╙ 13 ࿁ᣣᧄᓸ↢‛⾗Ḯቇળ(ᐔᚑ 18 ᐕ 6 ᦬㧘ၯ₹㧘ࠪࡦࡐࠫ࠙ࡓ‫∛ޟ‬ේ࿃ሶߩጁᱧࠍ៞タߒߚࠞ࡞࠴ࡖ࡯ࠦ࡟࡚ࠢࠪࡦߩ⩶ᩣᖱႎ⊒ାߣᓎഀ‫ޠ‬Ṷ⠪)
3㧕 ╙ 41 ࿁ᣣ☨ࠦ࡟࡜วหㇱળ(ᐔᚑ 18 ᐕ 11 ᦬㧘ጘ㒂㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬E. coli (1)‫ޠ‬ᐳ㐳)
4㧕 ╙ 26 ࿁ᣣᧄᓸ↢‛♽⛔ಽ㘃⎇ⓥળ(ᐔᚑ 18 ᐕ 11 ᦬㧘ጘ㒂㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ᄙ᭽ߥㆮવሶࠍᜬߟ਄
૏ಽ㘃㓏⚖ߦߤߩࠃ߁ߥᯏ⢻ᖱႎࠍઃടߔࠆ߆‫ޠ‬Ṷ⠪)5㧕 ⅣႺࡆࠫࡀࠬࠦࠕഃ಴࠮ࡒ࠽࡯(ᐔᚑ 19 ᐕ 8 ᦬㧘ᄢ㒋㧘⻠Ṷ)㧙㧙6㧕 ╙ 21 ࿁ International workshop in Space Microbiology(ᐔᚑ 19 ᐕ 9 ᦬㧘᧲੩㧘JAXA ࿖㓙ࠪࡦࡐࠫ࠙ࡓ)7㧕 ࠽࡚ࠪ࠽࡞ࡃࠗࠝࡊࡠࠫࠚࠢ࠻(ᐔᚑ 19 ᐕ 9 ᦬㧘ජ⪲‫ޟ‬ᣂᗵᨴ∝ᴺ߳ߩኻᔕ‫ޠ‬Ṷ⠪)8㧕 ICCC 11 Goslar Germany(ᐔᚑ 19 ᐕ 10 ᦬㧘࠼ࠗ࠷㧘̌DnaJ sequences as a new species
identification of bacteria̍Ṷ⠪)
9㧕 ╙ 27 ࿁ᣣᧄᓸ↢‛♽⛔ಽ㘃⎇ⓥળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ጊ᪸㧘‫ߩ⩶⚦ޟ‬਄૏ಽ㘃㓏⚖‫ޠ‬Ṷ⠪)10㧕 ╙ 27 ࿁ᣣᧄᓸ↢‛♽⛔ಽ㘃⎇ⓥળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ጊ᪸㧘‫ߩ⩶⚦ޟ‬਄૏ಽ㘃㓏⚖‫ޠ‬Ṷ⠪)11㧕 ╙ 52 ࿁ᣣᧄㄘ⧓ቇળ(ᐔᚑ 20 ᐕ 3 ᦬㧘ฬฎደ,‫ࠗ࡟ࠕࡠࠢࠗࡑޟ‬෸߮ቯ㊂ PCR ᴺࠍ૶ߞߚⅣႺਛߩ
∛ේ૕ߩࠬࠢ࡝࡯࠾ࡦࠣߣࡐࡇࡘ࡟࡯࡚ࠪࡦ⸃ᨆ‫ޠ‬Ṷ⠪)12㧕 ᣣᧄᗵᨴ∝ቇળ⻠Ṷ(‫ޟ‬㘩ਛᲥ⚦⩶ߩᬌ಴࡮หቯࠪࠬ࠹ࡓߩᣂዷ㐿‫ޠ‬Ṷ⠪)
13㧕 ᣣᧄㆮવሶ⸻≮ቇળ(ᐔᚑ 20 ᐕ㧘‫⩶⚦ޟ‬ᗵᨴ∝‫ޠ‬Ṷ⠪)
14㧕 ╙ 30 ࿁ᣣᧄ㘩ຠᓸ↢‛ቇળ(ᐔᚑ 20 ᐕ㧘ᐢፉ㧘‫ޟ‬㘩ਛᲥ⚦⩶ߩᬌ಴࡮หቯࠪࠬ࠹ࡓߩᣂዷ㐿‫ޠ‬Ṷ⠪)
15㧕 ᣣᧄᓸ↢‛⾗Ḯቇળ(ᐔᚑ 20 ᐕ㧘‫଻⛔♽ߩ⩶⚦ޟ‬ሽᵴേ߆ࠄ⷗߃ߡ߈ߚ⩶⒳ߩౣቯ⟵߳ߩ⺖㗴‫ޠ‬Ṷ⠪)ᄢᬮᷡᢥ㧦
1㧕 ජ⪲⋵⥃ᐥᓸ↢‛⎇ⓥ⃰⻠Ṷળ(ᐔᚑ 18 ᐕ 1 ᦬㧘ජ⪲㧘ᢎ⢒⻠Ṷቶ‫∛ޟ‬㒮ᬌᩏቶߦዉ౉น⢻ߥᗵᨴ∝ㆮવሶᬌᩏߩ᭴▽ࠍ⋡ᜰߒߡ㧦ㆮવሶᬌᩏ߇᦭↪ߢ޽ߞߚ∝଀ߩᢙ‫ޠޘ‬Ṷ⠪)2㧕 ᄢ㒋ᐭ⥃ᐥᬌᩏᛛᏧળቇⴚㇱᗵᨴ࡮఺∉ᬌᩏㇱ㐷ᓸ↢‛ᬌᩏಽ㊁↢ᶦᢎ⢒⎇ୃ(ᐔᚑ 18 ᐕ 1 ᦬㧘ᄢ㒋㧘ᢎ⢒⻠Ṷቶ‫ޟ‬ㆮવሶᬌᩏᵴ↪ⴚᢎ߃߹ߔ‫ޠ‬Ṷ⠪)
3㧕 ╙ 17 ࿁ᣣᧄ⥃ᐥᓸ↢‛ቇળ✚ળ(ᐔᚑ 18 ᐕ 1 ᦬㧘ᮮᵿ㧘․೎⻠Ṷ‫ⴕޟ‬೉ߩߢ߈ࠆㆮવሶ⎇ⓥቶ㧙⎇ⓥቶ߆ࠄᬌᩏቶ߳ߩࠕࡊࡠ࡯࠴ߘߒߡ࡜ࡦ࠺ࠖࡦࠣ㧙‫ޠ‬Ṷ⠪)
4㧕 ╙ 45 ࿁↢૕කᎿቇળᄢળ(ᐔᚑ 18 ᐕ 5 ᦬㧘ඳᄙ㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ቝቮ⦁ౝߢߩᗵᨴ∝⸻ᢿ෸߮⦁ౝ
⩶ฌߩࡕ࠾࠲࡯ࠪࠬ࠹ࡓ‫ޠ‬Ṷ⠪)
5㧕 ╙ 10 ࿁ർᶏ㆏࡮᧲ർᓸ↢‛⎇ⓥળ(ᐔᚑ 18 ᐕ 5 ᦬㧘ᧅᏻ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᣣᏱᬌᩏߢหቯ࿎㔍ߥ⩶ᩣߩหቯ㧙ᦨᣂߩᛛⴚࠍ㚟૶ߒߡ㧙‫ޠ‬Ṷ⠪)6㧕 ᣂẟ⋵⥃ᐥⴡ↢ᬌᩏᛛᏧળᗵᨴ೙ᓮㇱ㐷ᓸ↢‛㗔ၞ⎇ୃળ(ᐔᚑ 18 ᐕ 7 ᦬㧘ᣂẟ㧘․೎⻠Ṷ‫ࠆߥޟ‬߶ߤ㧍ᗵᨴ∝ߩㆮવሶᬌᩏ㨪ㆮવሶᬌᩏᴺߩၮ␆߆ࠄ⃻⁁ߘߒߡ੹ᓟߩዷᦸ‫ޠ‬Ṷ⠪)7㧕 2006 ᐕᐲ JICA ⥃ᐥᬌᩏᛛⴚ⎇ୃળ(ᐔᚑ 18 ᐕ 11 ᦬㧘᧲੩㧘․೎⻠Ṷ‫ⴊޟ‬ᶧ࡮㜑ᶧᬌᩏᴺ‫ޠ‬Ṷ⠪)8㧕 ╙ 22 ࿁ጟጊ⥃ᐥᓸ↢‛⎇ⓥળ(ᐔᚑ 18 ᐕ 11 ᦬㧘ጟጊ㧘․೎⻠Ṷ‫⩶⚦ޟ‬หቯߦ⧰ᘦߒߚ㓙ߦᓎ┙ߟಽሶ↢‛ቇ⊛หቯᣇᴺ‫ޠ‬Ṷ⠪)9㧕 ᣣᧄ⥃ᐥᬌᩏᛛᏧળ ᐔᚑ 18 ᐕᐲᗵᨴ೙ᓮㇱ㐷⎇ୃળ(ᐔᚑ 18 ᐕ 11 ᦬㧘╳ᵄ㧘․೎⻠Ṷ‫ޟ‬ᗵᨴ∝ㆮવሶᬌᩏߩ⥃ᐥᔕ↪ߩน⢻ᕈ‫ޠ‬Ṷ⠪)10㧕 ⑔ፉ⋵⥃ᐥⴡ↢ᬌᩏᛛᏧળ ᗵᨴ೙ᓮㇱ㐷ᓸ↢‛㗔ၞ⎇ୃળ(ᐔᚑ 18 ᐕ 12 ᦬㧘㇭ጊ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᗵᨴ∝㗔ၞߦ߅ߌࠆㆮવሶᬌᩏߩ᦭↪ᕈ㧦ࡕࡗ࠶ߣߒߚ⩶ᩣ㧒ᬌ૕߽ㆮવሶᬌᩏߢࠬ࠶ࠠ࡝‫ޠ‬Ṷ⠪)11㧕 ⑔ፉ⋵⥃ᐥⴡ↢ᬌᩏᛛᏧળ ╙ 14 ࿁ቇⴚ⻠Ṷળ(ᐔᚑ 18 ᐕ 12 ᦬㧘㇭ጊ㧘․೎⻠Ṷ‫ޟ‬ᣣᧄߣ☨࿖ߩ⥃ᐥᬌᩏቶߢߩߔ߫ࠄߒ߈ੱ‫ߩߣޘ‬಴ㅩ޿㧙น⢻ᕈߩ޽ࠆࠊ߇࿖ߩ⥃ᐥᬌᩏᛛᏧ㧙‫ޠ‬Ṷ⠪)12㧕 ╙ 56 ࿁ᣣᧄකቇᬌᩏቇળ(ᐔᚑ 19 ᐕ 5 ᦬㧘ችፒ㧘ࠪࡦࡐࠫ࠙ࡓ‫⚻ޟ‬ᷣല₸ࠍㅊ෸ߒߚ⑳㆐ߩឭ᩺㧙☨࿖ߩ⃻⁁߆ࠄ⠨߃ࠆ㧙‫ޠ‬Ṷ⠪)
13㧕 ╙ 20 ࿁⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળ✚ળ(ᐔᚑ 19 ᐕ 7 ᦬㧘੩ㇺ㧘ࠪࡦࡐࠫ࠙ࡓ‫ߩࠄ߆ࠇߎޟ‬ᓸ↢‛ㄦㅦ⸻ᢿߩᣇะ㧙ㆮવሶᬌᩏ㧙‫ޠ‬Ṷ⠪)
14㧕 ౓ᐶ⋵⥃ᐥᬌᩏᛛᏧળᓸ↢‛ᬌᩏ⎇ୃળ(ᐔᚑ 19 ᐕ 9 ᦬㧘␹ᚭ㧘․೎⻠Ṷ‫ᦨޟ‬వ┵࡮ㆮવሶᬌᩏߦ
ࠃࠆ⚦⩶ߩหቯߣᗵᨴ∝⸻ᢿ‫ޠ‬Ṷ⠪)
15㧕 ᧲੩ㇺ⥃ᐥᬌᩏᛛᏧળᓸ↢‛ᬌᩏ⎇ୃળ(ᐔᚑ 19 ᐕ 10 ᦬㧘᧲੩㧘․೎⻠Ṷ‫ޟ‬ㆮવሶᬌᩏ‫ޠ‬Ṷ⠪)16㧕 2007 ᐕᐲ JICA ⥃ᐥᬌᩏᛛⴚ⎇ୃળ(ᐔᚑ 19 ᐕ 11 ᦬㧘․೎⻠Ṷ‫ⴊޟ‬ᶧ࡮㜑ᶧᬌᩏᴺ‫ޠ‬Ṷ⠪)17㧕 㒮ౝᗵᨴ⎇ୃળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ᾢᧄ㧘․೎⻠Ṷ‫ޟ‬ᣣᏱߩ⥃ᐥᓸ↢‛ᬌᩏߢㆮવሶᬌᩏߩഥߌ߇ᔅ
ⷐߥߩߪߤࠎߥᤨ㧫‫ޠ‬Ṷ⠪)18㧕 ᐔᚑ 19 ᐕᐲጘ㒂⋵⥃ᐥⴡ↢ᬌᩏᛛᏧળ⑺ቄ᜛ᄢ⎇ୃળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫☨ޟ‬࿖ߦ߅ߌࠆᬌᩏ૕೙ߩ⃻⁁߆ࠄ੹ᓟߩᗵᨴ∝ᬌᩏࠍ⠨߃ࠆ‫ޠ‬Ṷ⠪)
19㧕 ᄢಽ⋵⥃ᐥⴡ↢ᬌᩏᛛᏧળ ╙ 4 ࿁ᗵᨴ೙ᓮㇱ㐷⎇ୃળ(ᐔᚑ 20 ᐕ 1 ᦬㧘ᄢಽ㧘․೎⻠Ṷ‫ޟ‬ㆮવሶᬌᩏߩၮ␆߆ࠄᔕ↪‫ޠ‬Ṷ⠪)20㧕 ╙ 19 ࿁ᣣᧄ⥃ᐥᓸ↢‛ቇળ✚ળ(ᐔᚑ 20 ᐕ 1 ᦬㧘᧲੩㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ㄦㅦ⸻ᢿᬌᩏ㧦ߘߩ᦭↪ᕈߣ዁᧪ዷᦸ 4㧚ㆮવሶᬌᩏԚ ㄦㅦㆮવሶ⸃ᨆߩ⩶⒳หቯ߳ߩኻᔕ‫ޠ‬Ṷ⠪)
21㧕 ╙ 23 ࿁ᣣᧄⅣႺᗵᨴቇળ✚ળ(ᐔᚑ 20 ᐕ 2 ᦬㧘㐳ፒ㧘ࠪࡦࡐࠫ࠙ࡓ‫⥃ޟ‬ᐥᬌᩏࠍߤߩࠃ߁ߦᗵᨴኻ㧙㧙╷ߦᓎ┙ߡࠆ߆ 4㧚ㆮવሶᬌᩏ㧦ᗵᨴ∝ߩㄦㅦ⸻ᢿߣಽሶ∉ቇ⸃ᨆ‫ޠ‬Ṷ⠪)22㧕 ╙ 82 ࿁ᣣᧄᗵᨴ∝ቇળ✚ળ(ᐔᚑ 20 ᐕ 4 ᦬㧘᧻ᳯ㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ᗵᨴ∝ߩㄦㅦ⸻ᢿᴺߩᣂߒ޿ዷ
㐿 4㧚ోりᗵᨴ∝ߩㄦㅦㆮવሶ⸻ᢿᴺ‫ޠ‬Ṷ⠪)23㧕 ╙ 83 ࿁ᣣᧄ⚿ᩭ∛ቇળ✚ળ(ᐔᚑ 20 ᐕ 4 ᦬㧘᧲੩㧘ࠪࡦࡐࠫ࠙ࡓ‫⥃ޟ‬ᐥ᛫㉄⩶ቇߩᦨ೨✢ 2㧚ㆮવሶᬌᩏߦࠃࠆ᛫㉄⩶ᗵᨴ∝ߩㄦㅦ⸻ᢿ‫ޠ‬Ṷ⠪)24㧕 ᐔᚑ 20 ᐕᐲ ࿖┙ᄢቇ∛㒮ᗵᨴኻ╷ද⼏ળ කᏧ࡮⋴⼔Ꮷࡉࡠ࠶ࠢ೎⃰⎇ୃળ(ᐔᚑ 20 ᐕ 6 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫ޟ‬ᗵᨴ∝ߩㄦㅦ⸻ᢿߣಽሶ∉ቇ⸃ᨆ‫ޠ‬Ṷ⠪)25㧕 ᐔᚑ 20 ᐕᐲ ╙ 2 ࿁ᓸ↢‛ᬌᩏ⎇ⓥ⃰⎇ୃળ(ᐔᚑ 20 ᐕ 7 ᦬㧘ජ⪲㧘․೎⻠Ṷ‫ޟ‬ㆮવሶᬌᩏ߆ࠄ⥃ᐥ⸻ᢿ߳ߩࠕࡊࡠ࡯࠴‫ޠ‬Ṷ⠪)26㧕 ╙ 21 ࿁㑐᧲↲ା࿾඙ᓸ↢‛ᬌᩏ⎇ୃળ(ᐔᚑ 20 ᐕ 9 ᦬㧘㐳㊁㧘․೎⻠Ṷ‫ޟ‬ㆮવሶᬌᩏߩ዁᧪௝㧙ߘߩน⢻ᕈߣᔕ↪㧙‫ޠ‬Ṷ⠪)27㧕 ᐔᚑ 20 ᐕᐲ྾࿖࿾඙ᓸ↢‛ᬌᩏ⎇ୃળ(ᐔᚑ 20 ᐕ 9 ᦬㧘᧻ጊ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᗵᨴ∝⸻ᢿߢㄦㅦㆮવሶ
ᬌᩏࠍᵴ↪ߔࠆߩߪߤࠎߥᤨ㧫‫ޠ‬Ṷ⠪)28㧕 ╙ 48 ࿁ㄭ⇰කቇᬌᩏቇળ(ᐔᚑ 20 ᐕ 10 ᦬㧘␹ᚭ㧘․೎⻠Ṷ‫☨ޟ‬࿖ߩ⥃ᐥᓸ↢‛ᬌᩏߩ⃻ᴫ߆ࠄ੹ᓟߩᬌᩏ૕೙ࠍ⠨߃ࠆ‫ޠ‬Ṷ⠪)29㧕 ╙ 15 ࿁ਛㇱᓸ↢‛ᬌᩏ⎇ⓥ⃰ኋᴱ⎇ୃળ(ᐔᚑ 20 ᐕ 10 ᦬㧘ጘ㒂㧘ᢎ⢒⻠Ṷ‫ߩޘᤨޟ‬ㆮવሶᬌᩏ ᔓࠆߴ߆ࠄߕ㧙ㆮવሶᬌᩏࠍᵴ↪ߒߚᗵᨴ∝⸻≮ᡰេ㧙‫ޠ‬Ṷ⠪)↲⇌ବ㇢㧦
1㧕 ╙ 54 ࿁ᣣᧄൻቇ≮ᴺቇળ✚ળ(ᐔᚑ 18 ᐕ 5 ᦬㧘੩ㇺ㧘ࠪࡦࡐࠫ࠙ࡓ‫੹ޟ‬ᓟᵈ⋡ߐࠇࠆᗵᨴ∝ ࡄ࡯ࠠࡦ࠰ࡦ∛ߣࡁࠞ࡞ࠫࠕ‫ޠ‬Ṷ⠪)
2㧕 ╙ 43 ࿁ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ✚ળ(ᐔᚑ 18 ᐕ 10 ᦬㧘ጘ㒂㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ᓸ↢‛߇ේ࿃࡮ᘾᖡ࿃
ሶߣߥࠆ∔ᖚߦߟ޿ߡߩᦨㄭߩ⹤㗴 ࡄ࡯ࠠࡦ࠰ࡦ∛㧧ߘߩේ࿃ߦ߅ߌࠆࡁࠞ࡞ࠫࠕᗵᨴ㑐ਈߩน⢻ᕈ‫ޠ‬Ṷ⠪)8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫ1㧕 ᳯፒቁⴕ㧦ᣣᧄᓸ↢‛⾗Ḯቇળ⾨(ᐔᚑ 20 ᐕᐲ)
9㧚␠ળᵴേᳯፒቁⴕ㧦
1㧕 ᣣᧄቇⴚળ⼏ㅪ៤ᆔຬ㧘࿖㓙੐ᬺᆔຬ㧘․೎⎇ⓥᆔຬ(㨪⃻࿷)2㧕 ㅢ↥⋭ ↥ᬺ᭴ㅧᆔຬ㧘ൻቇ࡮ࡃࠗࠝㇱળ⚵ߺᦧ߃ DNA ᛛⴚዊᆔຬ(㨪⃻࿷)3㧕 ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯දળ㧘ⅣႺኻᔕᛛⴚ㐿⊒ᆔຬ(㨪⃻࿷)4㧕 ⁛┙ⴕ᡽ᴺੱ⵾ຠ⹏ᛛⴚၮ⋚ᯏ᭴ㆮવሶ⚵឵߃↢‛╬ߩᬌ಴ᛛⴚᬌ⸛ᆔຬ(㨪⃻࿷)5㧕 ⁛┙ⴕ᡽ᴺੱ⵾ຠ⹏ᛛⴚၮ⋚ᯏ᭴ᮡḰൻᬺോផㅴᆔຬ(㨪⃻࿷)6㧕 ⁛┙ⴕ᡽ᴺੱᴒ✽⑼ቇᛛⴚ⎇ⓥၮ⋚ᢛ஻ᯏ᭴ࡃࠗࠝ࠮࡯ࡈ࠹ࠖ࡯ᆔຬ(㨪⃻࿷)7㧕 Bergy’s manual ࿖㓙ℂ੐(㨪⃻࿷)10㧚ႎ๔ᦠ
1㧕 ᳯፒቁⴕ㧦࡟ࠫࠝࡀ࡜ߩㆮવሶᬌᩏ߅ࠃ߮᛫૕ᬌᩏᴺߩ૞ᚑߦ㑐ߔࠆ⎇ⓥ㧦ᐔᚑ 15 ᐕᐲ㧙ᐔᚑ 17ᐕᐲෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ✚᜝࡮ಽᜂ✚ว⎇ⓥႎ๔ᦠ(ศ↰⃰)㧦45㧙48 (2006 ᐕ 3 ᦬)
2㧕 ᳯፒቁⴕ㧦ࡑࠗࠢࡠࠕ࡟ࠗࠍ↪޿ߚⅣႺਛߩ∛ේᓸ↢‛╬ߩࡕ࠾࠲࡝ࡦࠣ㧦ㆮવሶ⚵ߺ឵߃૕ߩ↥ᬺ೑↪ߦ߅ߌࠆ࡝ࠬࠢ▤ℂߦ㑐ߔࠆ⎇ⓥ ᛛⴚ⾗ᢱ㓸㧦172㧙223 (2006 ᐕ 3 ᦬)
3㧕 ᳯፒቁⴕ࡮ᄢᬮᷡᢥ㧦࠽࡚ࠪ࠽࡞ࡃࠗࠝ࡝࠰࡯ࠬࡊࡠࠫࠚࠢ࠻ ᐔᚑ 17 ᐕᐲ⹏ଔႎ๔ᦠ㧘ᢥㇱ⑼ቇ
⋭ ᣂ਎♿㊀ὐ⎇ⓥഃ਎ࡊ࡜ࡦ㧦49㧙51 (2006 ᐕ 3 ᦬)
4㧕 ᳯፒቁⴕ㧦ᐔᚑ 17 ᐕᐲⅣႺኻᔕᛛⴚ㐿⊒╬ ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯ ቟ోኻ╷⺞ᩏႎ๔ᦠ (2006ᐕ 3 ᦬)
5㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦ਅ∯ߩ⣺ౝ⚦⩶ฌߩ⎇ⓥᣇᴺߩ㐿⊒㧦ᐔᚑ 18 ᐕᐲෘ↢ഭ௛⑼ቇ⎇ⓥ⾌࿖㓙කቇදജ⎇ⓥ੐ᬺ ✚᜝࡮ಽᜂ⎇ⓥႎ๔ᦠ㧦153㧙159 (2006 ᐕ 12 ᦬)
6㧕 ᳯፒቁⴕ㧦ᐔᚑ 18 ᐕᐲⅣႺኻᔕᛛⴚ㐿⊒╬ ࡃࠗࠝࠗࡦ࠳ࠬ࠻࡝࡯ 213㧙241 ቟ోኻ╷⺞ᩏႎ๔ᦠ(2007 ᐕ 3 ᦬)
7㧕 ᳯፒቁⴕ࡮ᄢᬮᷡᢥ㧦࠽࡚ࠪ࠽࡞ࡃࠗࠝ࡝࠰࡯ࠬࡊࡠࠫࠚࠢ࠻ ᐔᚑ 18 ᐕᐲ⹏ଔႎ๔ᦠ㧘ᢥㇱ⑼ቇ
⋭ ᣂ਎♿㊀ὐ⎇ⓥഃ਎ࡊ࡜ࡦ㧦49㧙51 (2007 ᐕ 3 ᦬)㧙㧙

8㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦⚦⩶ᕈ⣺▤ᗵᨴ∝ߩ∛ᘒ⸃ᨆߣߘߩᔕ↪⊛⎇ⓥ㧦ᐔᚑ 19 ᐕᐲෘ↢ഭ௛⑼ቇ⎇ⓥ⾌࿖㓙කቇදജ⎇ⓥ੐ᬺ ✚᜝࡮ಽᜂ⎇ⓥႎ๔ᦠ㧦102㧙104 (2007 ᐕ 12 ᦬)
9㧕 ᳯፒቁⴕ㧘ᄢᬮᷡᢥ㧦࠽࡚ࠪ࠽࡞ࡃࠗࠝ࡝࠰࡯ࠬࡊࡠࠫࠚࠢ࠻ ᐔᚑ 19 ᐕᐲ⹏ଔႎ๔ᦠ㧘ᢥㇱ⑼ቇ
⋭ ᣂ਎♿㊀ὐ⎇ⓥഃ਎ࡊ࡜ࡦ㧦49㧙51 (2008 ᐕ 3 ᦬)
11㧚ႎ㆏
1㧕 ᳯፒቁⴕ㧦㧔ࡁࡠߥߤਅ∯ᗵᨴ∝ኻ╷ߦ㧕࠙ࠗ࡞ࠬ 100 ⒳ 2 ᣣߢ․ቯ㧦ਛᣣᣂ⡞(2007 ᐕ 1 ᦬ 25 ᣣ)
2㧕 ᳯፒቁⴕ㧦ⅣႺ‫ޔ‬㘩ߩ቟ోߢ౒ห⎇ⓥ㧔ጘ㒂ᄢකቇㇱߣ☨ࠦࡠ࡜࠼Ꮊ┙ᄢឭ៤㧕㧦ጘ㒂ᣂ⡞(2008 ᐕ
11 ᦬ 19 ᣣ)
12㧚⥄Ꮖ⹏ଔ
⹏ଔౣ↢ක⑼ቇኾ᡹ߢ 2 ᐕߩୃ჻⺖⒟ߣ 3 ᐕߩඳ჻⺖⒟ߩቇ↢ߩᢎ⢒⎇ⓥߦᓥ੐ߒ㧘ᒰೋ⸘↹ߒߚୃ჻ߢ
∛ේᓸ↢‛ߩขࠅᛒ޿⚻㛎ߩ޽ࠆኾ㐷ኅࠍ⢒ᚑߒ␠ળߦㅍࠅ಴ߔ‫ޕ‬ඳ჻⺖⒟ߢߪ∛ේ⚦⩶ࠍ૶ߞߚ⎇ⓥߦᓥ੐ߐߖ㧘ኾ㐷ኅࠍ⢒ᚑߔࠆ⸘↹ࠍ┙ߡߚ‫ୃߪ⊛⋡ߩߎޕ‬჻⺖⒟ߩතᬺ↢ߪ∛ේ⚦⩶ߩขࠅᛒ޿߇ߢ
߈ࠆੱ᧚ߣߒߡዞ⡯ᵴേ߇ࠬࡓ࡯࠭ߦዷ㐿ߒ㧘ᒰೋߩ⸘↹߇㆐ᚑߐࠇߚ‫ߒ߆ߒޕ‬ඳ჻⺖⒟ߢߪ 3 ᐕ㑆ߣ޿߁⍴ᦼ㑆ߦኾ㐷ኅߩ⢒ᚑߪ࿎㔍ߢ޽ߞߚ‫߇ࡈ࠶࠲ࠬߦ․ޕ‬ዋߥ޿⃻⁁ߢ㧘ߔߴߡߩ∛ේ૕ߦኻߔࠆ৻
ቯ࡟ࡌ࡞ߩ⚻㛎ߣ⍮⼂ࠍ⠌ᓧߐߖߚੱ᧚⢒ᚑߦᚑഞߒߚߣߪ⸒߃ߥ޿‫ޕ‬♽⛔଻ሽ੐ᬺߪ࿖ߩᡰេࠍ߁ߌ㧘ࠗࡦࡈ࡜ߩᢛ஻ࠍផㅴߒ㧘∛ේ૕ࠍ଻᦭ߔࠆⅣႺߣߒߡߪ࿖㓙᳓Ḱߦ೔㆐ߒߚߣ⠨߃ߡ޿ࠆ‫ߩߎޕ‬ⅣႺࠍ⛽ᜬߔࠆ⚻ᷣ⊛ၮ⋚ࠍ੹ᓟ߽⛽ᜬߢ߈ࠆ⾗㊄ߩ⺞㆐߇ᔅⷐߦߥࠆ‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷ࠊ߇࿖ߦߪ∛ේᓸ↢‛ࠍ♽⛔଻ሽߒ㧘⎇ⓥ⠪ߦࠨ࡯ࡆࠬߔࠆ࿖ߩᯏ㑐߇ሽ࿷ߒߥ޿ߚ߼㧘ࠊࠇࠊࠇ߇
ⴕߞߡ޿ࠆࠨ࡯ࡆࠬߪࠊ߇࿖ߩ⎇ⓥၮ⋚ࠍၮ␆߆ࠄᡰ߃ࠆ㊀ⷐߥၮ⋚ߦߥߞߡ޿ࠆ‫ޕ‬ᢥㇱ⑼ቇ⋭ߩၮ⋚ᢛ஻੐ᬺߦࠃࠆᡰេ૕೙ߪᐕᐲߏߣߩ੍▚ߢㆇ༡ߐࠇߡ߅ࠅ㧘ߎࠇ߹ߢߩᡰេߢࠗࡦࡈ࡜ᢛ஻ࠍ߅ߎߥ
ߞߚ߇㧘ᰴᐕᐲߩ੍▚ൻߪ⚂᧤ߐࠇߡ޿ߥ޿ߩߢ㧘ࠨ࡯ࡆࠬᬺോߦᓥ੐ߔࠆੱ᧚ߪ⎇ⓥ⾌߆ࠄࠕ࡞ࡃࠗ
࠻ߢ㓹↪ߔࠆߥߤ㧘ᭂ߼ߡਇ቟ቯߢ޽ࠆ‫ޕ‬⒖ォᓟ㧘ᄢቇ߇⩶ᩣ଻ሽቶߩ᦭ᢱൻࠍ᳿ቯߒ㧘⎇ⓥᡰេࠍⴕߥߞߡ޿ߥ޿⃻⁁ߢߪ㧘ᓸ↢‛⾗Ḯߩ᦭ᢱൻࠍଦㅴߒ㧘ੱ᧚ࠍ⏕଻ߒߥߌࠇ߫ߥࠄߥ޿‫ߦࠄߐޕ‬࿖࡟ࡌ࡞ߢߩ∛ේ૕ߩ♽⛔଻ሽ੐ᬺࠍᕡᏱ⊛ߥ੍▚ߦߔࠆ௛߈߆ߌ߇ᔅⷐߣ⠨߃ߡ޿ࠆ‫ޕ‬ᄢቇ㒮ᢎ⢒ߢߪඳ჻⺖⒟ᓟᦼߩතᬺ⠪ߩ㓹↪⏕଻߇੹ᓟߩ㊀ⷐߥ⺖㗴ߢ޽ࠆ߇㧘ᄢ߈ߥዷᦸߪ㐿ߌߡ޿ߥ޿‫⎇ޕ‬ⓥߩ㜞ᐲൻ㧘㓸ਛൻߢᄢဳߩ┹੎⊛⎇ⓥ⾗㊄ߩ⏕଻ߪ࿎㔍ߦߥߞߡ߅ࠅ㧘ࠃࠅ․⦡ߩ޽ࠆಽ
㊁߳⎇ⓥࠍ⛉ࠅㄟ߻ദജ߇ᔅⷐߣ⠨߃ߡ޿ࠆ‫ޕ‬੹ᓟߩዷᦸࠊ߇࿖ߢߪ∛ේᓸ↢‛ߩขࠅᛒ޿ߦ⠌ᾫߒߚੱ᧚߇ᷫዋߒߡ޿ࠆߩߢୃ჻㧘ඳ჻⺖⒟ߢߪ∛ේᓸ↢‛
ߦ․ൻߒߚੱ᧚ߩ⢒ᚑࠍ੹ᓟ߽⛮⛯ߔࠆ⸘↹ߢ޿ࠆ‫⎇ߚ߹ޕ‬ⓥቶ଻᦭ߩᓸ↢‛⾗Ḯࠍ⾗↥ߣߒߚᔕ↪ᛛⴚ㐿⊒ߪ੹ᓟ߽㊀ⷐߥ⎇ⓥ⾗㊄ߩ⺞㆐ᣇᴺߣ⠨߃ߡ߅ࠅ㧘ߎߩಽ㊁ߩ⎇ⓥࠍផㅴߔࠆ⸘↹ߢ޿ࠆ‫ߦ․ޕ‬㧘ࠊ߇࿖ߩၮ␆⎇ⓥߢߪ⺰ᢥ⊒⴫߇ఝవߒ㧘․⸵ߩขᓧߪᬺ❣ߣߒߡ޽߹ࠅ㊀ⷞߐࠇߡߎߥ߆ߞߚ߇㧘ᄢဳ┹੎⊛⎇ⓥ⾗㊄ߩ₪ᓧߦߪ․⸵ߩขᓧߪ㊀ⷐߥ⹏ଔ㗄⋡ߢ޽ࠆ‫ޕ‬Ⓧᭂ⊛ߦ⁛⥄ᕈࠍࠕࡇ࡯࡞ߢ߈ࠆಽ
㊁ߢߩ․⸵ࠍขᓧߒ㧘⎇ⓥ⾗㊄ߩ⺞㆐ߦߟߥߍߚ޿‫ޕ‬⎇ⓥߢߪ⃻࿷⫾Ⓧߒߡ޿ࠆ dnaJ ߩ࠺࡯࠲ࡌ࡯ࠬࠍߐࠄߦ᜛ᄢߒ㧘ᦨㄭߩ⒳ species ߩᣂߒ޿ㆮવቇ⊛᏷ࠍ⸘᷹ߒ㧘࿖㓙␠ળߦࠥࡁࡓᤨઍߩ⩶⒳ species ߩቯ⟵ࠍឭ᩺ߔࠆ‫ޕ‬㧙㧙ާౣ↢Ꮏቇ⻠ᐳި
㧔1㧕↢๮ᯏ⢻ಽሶ⸳⸘ಽ㊁1㧚⎇ⓥߩ᭎ⷐ
ᧄ⎇ⓥࠣ࡞࡯ࡊߢߪ㧘⣖࡮␹⚻ᯏ⢻ߩಽሶ࡟ࡌ࡞ߢߩ⸃᣿ߣߘࠇߦၮߠߊ∛ᘒᴦ≮⮎࡮⸻ᢿ⮎ߩ㐿⊒ࠍ⋡ᮡߦ㧘in vitro ߢߩࠪࠣ࠽࡞⸃ᨆࡊࡠ࡯ࡉ߆ࠄ୘૕ߩ߽ߟࠪࠬ࠹ࡓߣߒߡߩ in vivo ߢߩ↢૕ᯏ⢻ߩ⸃ᨆ࡮೙ᓮࠍታ⃻ߔࠆ㜞ᯏ⢻ૐಽሶࡊࡠ࡯ࡉ㧔PET ࡊࡠ࡯ࡉࠍ฽߻㧕ߩഃ⵾⎇ⓥࠍⴕߞߡ޿ࠆ‫ߩࠇߕ޿ޕ‬⎇ⓥ߽ࡅ࠻߳ߩᔕ↪㧔ഃ⮎㧕ࠍⷞ㊁ߦ౉ࠇ㧘කቇ࡮↢‛ቇ♽ߩ⎇ⓥࠣ࡞࡯ࡊߣߩቇ㓙࡮ቇⲢ⊛౒ห⎇ⓥࠍዷ㐿ߒߡ޿ࠆ‫ޕ‬1㧕ਛᨔ␹⚻଻⼔૞↪ࠍ␜ߔࡊࡠࠬ࠲ࠣ࡜ࡦࠫࡦಽሶࡊࡠ࡯ࡉߩഃ⵾
㜞㉄⚛⁁ᘒߢᒁ߈⿠ߎߐࠇࠆᶏ㚍␹⚻⚦⢩ߩࠕࡐ࠻࡯ࠪࠬࠍ㒖ኂߔࠆߥߤᒝജߥ␹⚻଻⼔૞↪ࠍ␜ߔࡊࡠࠬ࠲ࠣ࡜ࡦࠫࡦ㘃✼૕ 15R-TIC ࠍഃ⵾ߒ㧘㓁㔚ሶ᡼኿ᢿጀ↹௝᠟ᓇᴺ㧔PET㧕ߦࠃࠆࡅ࠻⣖ߢߩ invivo ⣖ౝേᘒߣฃኈ૕ߩ↹௝ൻߦᚑഞߒߚ‫ޕ‬15R-TIC ߪ⣖ౝਛᨔ␹⚻♽⚵❱ߦሽ࿷ߔࠆᣂⷙࡊࡠࠬ࠲ࠨ
ࠗࠢ࡝ࡦฃኈ૕ߦ․⇣⊛ߦ⚿วߔࠆߎߣࠍ⸽᣿ߒߡ޿ࠆ߇㧘ߘߩฃኈ૕᝝₪࡮หቯߩߚ߼ߩ non-RI ဳశⷫ๺ᕈᮡ⼂ࡊࡠ࡯ࡉ߿ࠕࡈࠖ࠾࠹ࠖࠥ࡞ߩಽሶ⸳⸘߅ࠃ߮วᚑ⎇ⓥࠍⴕߞߡ޿ࠆ‫ߚ߹ޕ‬㧘15R-TIC ߩ⣖ᯏ⢻ᡷༀ⮎࡮␹⚻ᄌᕈ∔ᖚߩᴦ≮⮎ߣߒߡߩ㐿⊒ߦะߌߡ㧘࡝࠴࠙ࡓࠛࡁ࡜࡯࠻ߩ᭴ㅧ߅ࠃ߮෻ᔕᕈߦ㑐ߔࠆၮ␆⎇ⓥࠍዷ㐿ߒ㧘3 ᚑಽㅪ⚿ࡊࡠࠬ࠲ࠣ࡜ࡦࠫࡦวᚑᴺࠍၮゲߣߔࠆࠣ࡝࡯ࡦࡊࡠ࠮ࠬߦࠃࠆᄢ㊂
วᚑᴺߩ⏕┙ࠍ߼ߑߒߡ޿ࠆ‫ߦࠄߐޕ‬㧘␹⚻⓭⿠િዷଦㅴ૞↪ߣ㉄ൻࠬ࠻࡟ࠬߦࠃࠆ␹⚻⚦⢩ᱫࠍᛥ೙ߔ
ࠆోߊᣂߒ޿૞↪ࠍᜬߟࡊࡠࠬ࠲ࠣ࡜ࡦࠫࡦ㘃✼૕ NEPP ߿㧘GDNF ⺃ዉଦㅴ૞↪ࠍ␜ߔᣂⷙࠪࠢࡠࡍ
ࡦ࠹ࡁࡦൻว‛ߩഃ⵾ߦᚑഞߒߡ߅ࠅ㧘ߘߩ↢૕ౝᮡ⊛ಽሶߩหቯߣ૞↪ࡔࠞ࠾࠭ࡓߩ⸃᣿㧘PET ߦࠃࠆࠗࡔ࡯ࠫࡦࠣߥߤࠍ߼ߑߒߚಽሶࡊࡠ࡯ࡉߩ⸳⸘࡮วᚑࠍⴕߞߡ޿ࠆ‫ޕ‬
2㧕㜞ㅦࡔ࠴࡞ൻ෻ᔕߦࠃࠆ PET ࡊࡠ࡯ࡉߩഃ⵾
PET ⎇ⓥߢ↪޿ࠄࠇࠆ⍴ኼ๮᡼኿ᩭߢ޽ࠆ 11C ࠍᜬߟࡔ࠴࡞ၮࠍ㧘᦭ᯏಽሶߦ⍴ᤨ㑆ߢ㜞ല₸⊛ߦዉ౉ߔࠆ↹ᦼ⊛ߥൻቇ෻ᔕࠍ㐿⊒ߒߚ‫ޕ‬㒢ቯߐࠇߚ᭴ㅧࠍᜬߟൻว‛ߩઍ⻢ਇ቟ቯߥㇱ૏ࠍ࡜ࡌ࡞ൻߔࠆᓥ
᧪ᴺߣߪ⇣ߥࠅ㧘ᧄᴺߪ὇⚛὇⚛⚿วࠍᒻᚑߔࠆߚ߼㧘߶ߣࠎߤ޽ࠄࠁࠆ᦭ᯏಽሶߦߟ޿ߡઍ⻢቟ቯߥ
PET ࡊࡠ࡯ࡉൻ߇น⢻ߢ޽ࠆ‫ߩߎޕ‬ᣂᛛⴚࠍၮ⋚ߦ㧘ߎࠇ߹ߢߩࠣ࡞ࠦ࡯ࠬ߿᳓ߩ࡜ࡌ࡞૕ࠍ↪޿ߚઍ⻢⊛ߥ⸃ᨆ⎇ⓥ߆ࠄ㧘ฃኈ૕߿࠲ࡦࡄࠢ⾰ߥߤߩ↢૕ౝಽሶ߿⮎೷ಽሶߘߩ߽ߩࠍนⷞൻߔࠆᣂ਎ઍ
PET ࠗࡔ࡯ࠫࡦࠣ⎇ⓥ߇ዷ㐿ߐࠇࠆ߽ߩߣ⠨߃ࠄࠇࠆ‫ᧄޕ‬ᚻᴺߩᔕ↪ߦࠃࠆᧃ᪳♽ࡊࡠࠬ࠲ࠨࠗࠢ࡝ࡦ
ฃኈ૕㧘ࡌࡦ࠱ࠫࠕ࠯ࡇࡦฃኈ૕㧘⣖ౝࠛࠬ࠻ࡠࠥࡦฃኈ૕㧘ᩭౝ࡟࠴ࡁࠗࡦ㉄ฃኈ૕ߩࠗࡔ࡯ࠫࡦࠣ㧘ᜂ≸ࡑ࠙ࠬࠍ↪޿ߚ⣲≌ࠗࡔ࡯ࠫࡦࠣ㧘ࠕ࡞࠷ࡂࠗࡑ࡯∛ߩ⸻ᢿߣߥࠆ⣖ౝࠕࡒࡠࠗ࠼Ǫࠗࡔ࡯ࠫࡦࠣߥ
ߤߦะߌߚ PET ࡊࡠ࡯ࡉߩวᚑࠍⴕߞߡ޿ࠆ‫ߚ߹ޕ‬㧘෻ᔕⵝ⟎ߩࡒࠢࡠൻ㧔ࡑࠗࠢࡠ࡝ࠕࠢ࠲࡯㐿⊒㧕ߣ㧘⾆㊀ߥၮ⾰ߩ૶↪㊂ߩ೥ᷫ㧘෻ᔕല₸ߩะ਄ߥߤࠍ߼ߑߒߚ㧘ᦨవ┵࠽ࡁ࠹ࠢࡁࡠࠫ࡯ᛛⴚߩᔕ↪ߦࠃࠆ PET ↪♖ኒวᚑⵝ⟎ߩ㐿⊒ࠍㅴ߼ߡ޿ࠆ‫ޕ‬
3㧕ਛᨔ␹⚻૞↪ࠍᜬߟࠡࡦࠧ࡜ࠗ࠼⺃ዉ૕ߩ⸳⸘ߣ⣖ౝಽሶࠗࡔ࡯ࠫࡦࠣ
ࠗ࠴࡚࠙⪲ࠛࠠࠬࠃࠅᓧࠄࠇࠆࠡࡦࠦ࡜ࠗ࠼ߪ⣖ᯏ⢻ᡷༀ૞↪ࠍ␜ߔߎߣ߆ࠄ⹺⍮∝㧔ࠕ࡞࠷ࡂࠗࡑ࡯
∛㧕ߥߤߩᴦ≮⮎ߣߥࠆߣᦼᓙߐࠇߡ޿ࠆ‫ ߪߦ࠼ࠗ࡜ࠦࡦࠡޕ‬A㧘B㧘C㧘J ߩฦ㘃✼૕߇ሽ࿷ߒ㧘in vitroߢߪࠣ࡝ࠪࡦฃኈ૕㧘GABA ฃኈ૕㧘PAF ฃኈ૕ߥߤߩᯏ⢻ࠍ೙ᓮߔࠆߎߣ߇ႎ๔ߐࠇߡ޿ࠆ߇㧘⹦⚦ߥಽሶᯏ᭴߿ in vivo ߦ߅޿ߡ⣖ౝߦ೔㆐ߒߡ޿ࠆ߆ߥߤߪਇ᣿ߢ޽ࠆ‫ߢߎߘޕ‬㧘ࠡࡦࠦ࡜ࠗ࠼ߩ૕ౝേ
ᘒ߿ᮡ⊛ฃኈ૕ߩ⣖ౝಽᏓߥߤߩ⹦⚦ࠍ⸃ᨆߔࠆߚ߼㧘ࡐࠫ࠻ࡠࡦࠗࡔ࡯ࠫࡦࠣᴺߦะߌߚ PET ࡊࡠ࡯ࡉߩ⸳⸘߅ࠃ߮วᚑ⎇ⓥࠍⴕߞߡ޿ࠆ‫ߚ߹ޕ‬㧘ᄤὼࠡࡦࠦ࡜ࠗ࠼ࠃࠅᮡ⊛ฃኈ૕߳ߩ⚿ว⢻߇㜞޿⺃ዉ૕ࠍวᚑߒ㧘ߘߩ PET ࡊࡠ࡯ࡉൻߣዊേ‛ࠍ↪޿ߚࠗࡔ࡯ࠫࡦࠣ⎇ⓥߦࠃࠅหൻว‛߇⣖ౝߦ⒖ⴕߒߡ޿
ࠆߎߣࠍ⸽᣿ߒߚ‫ޕ‬
4㧕␹⚻࿃ᕈ−∩ߩ⊒∝ᯏ᭴⸃᣿ߣᴦ≮࡮⸻ᢿ⮎㐿⊒ߦะߌߚ․⇣⊛ಽሶࡊࡠ࡯ࡉߩഃ⵾
ࠕࡠ࠺ࠖ࠾ࠕߥߤߩ␹⚻࿃ᕈ−∩ߪᣢሽߩ㎾∩೷߇ല߆ߥ޿㔍ᴦᕈߩ∛ᘒߢ޽ࠅ㧘ᴦ≮⮎ߩ㐿⊒ߦߪ∛ᘒߦ߆߆ࠊࠆฃኈ૕߿ࠪࠣ࠽࡞ಽሶߩหቯߥߤ㧘ಽሶࡔࠞ࠾࠭ࡓߩ⸃᣿߇ਇนᰳߢ޽ࠆ‫ޕ‬Ქࠠࡁࠦ߆ࠄ᛽
಴ߐࠇߚࠕࡠ࠺ࠖ࠾ࠕ⺃⊒૞↪ࠍ␜ߔࠕࡒࡁ㉄ߩ᭴ㅧࠍၮߦಽሶࡊࡠ࡯ࡉࠍ⸳⸘࡮วᚑߒ㧘ߘߩᵴ↪ߦࠃࠅࠕࡠ࠺ࠖ࠾ࠕߦ߆߆ࠊࠆᣂⷙฃኈ૕ߩหቯߣᯏ⢻⸃ᨆࠍⴕߞߡ޿ࠆ‫ߚ߹ޕ‬㧘⮎‛ߦࠃࠅ⺃⊒ߐࠇࠆࠕࡠ
࠺ࠖ࠾ࠕࠍૐ↪㊂ߢᛥ೙ߔࠆൻว‛ߩഃ⵾ߦᚑഞߒ㧔࿖㓙․⸵㧕㧘␹⚻࿃ᕈ−∩ᴦ≮⮎ߣߒߡߩ㐿⊒⎇ⓥ
ߦ⌕ᚻߒߡ޿ࠆ‫ޕ‬
5㧕␹⚻⚦⢩ᱫᛥ೙೷ߩഃ⵾
␹⚻ᄌᕈ∔ᖚᴦ≮⮎ߩ㐿⊒ࠍ߼ߑߒߡ␹⚻⚦⢩ᱫᛥ೙૞↪ࠍ␜ߔૐಽሶൻว‛ߩ⸳⸘࡮วᚑ⎇ⓥࠍⴕߞߡ޿ࠆ㧚ߎࠇ߹ߢߦ㉄ൻࠬ࠻࡟ࠬ߅ࠃ߮ዊ⢩૕ࠬ࠻࡟ࠬ⚦⢩ࡕ࠺࡞♽ߦኻߒߡᒝജߥ⚦⢩ᱫᛥ೙૞↪ࠍ␜㧙㧙ߔൻว‛ࠍวᚑߔࠆߎߣߦᚑഞߒߡ߅ࠅ㧔․⸵಴㗿Ḱ஻ਛ㧕㧘૞↪ᯏᐨߩ⸃ᨆࠍㅴ߼ࠆߣߣ߽ߦ㧘in vivoേ‛ࡕ࠺࡞ߢߩ᦭ലᕈߩታ⸽ߦะߌߚ⎇ⓥࠍ㐿ᆎߒߚ‫ޕ‬
6㧕ᩭౝฃኈ૕ߩಽሶࠗࡔ࡯ࠫࡦࠣࡊࡠ࡯ࡉߩഃ⵾
ㆮવሶ⊒⃻ߩ೙ᓮߣ↢૕ᯏ⢻ߩ㑐ㅪࠍ PET ᴺߦࠃࠅ in vivo ߢ⸃ᨆߔࠆߚ߼㧘ᩭౝฃኈ૕ࠍ੺ߒߡㆮવ
ሶォ౮ࠍ೙ᓮߒߡ޿ࠆ࡟࠴ࡁࠗ࠼߅ࠃ߮㑐ㅪൻว‛ߩ PET ࠻࡟࡯ࠨ࡯ߩ⸳⸘෸߮วᚑࠍⴕߞߡ޿ࠆ‫ޕ‬7㧕ᣂ૞↪ᯏ᭴ࠍᜬߟ᛫࠙ࠗ࡞ࠬ೷ߩ㐿⊒ߣ PET ࠻࡟࡯ࠨ࡯ൻmRNA ߩࠬࡊ࡜ࠗࠪࡦࠣ෻ᔕߦ㑐ࠊࠆ࡝ࡦ㉄ൻ㉂⚛㧔SRPK㧕ࠍ㒖ኂߒ㧘ᚑᾫ mRNA ߩᒻᚑㆊ⒟ߩㅴ
ⴕࠍߊ޿ᱛ߼ࠆᣂⷙ᛫࠙ࠖ࡞ࠬ೷ߩ㐿⊒ࠍⴕߞߡ޿ࠆ‫ߥ߁ࠃߩߎޕ‬૞↪ᯏᐨࠍ߽ߟ SIS-1 ࠍ࡝࡯࠼ൻว
‛ߣߒ㧘ࠃࠅㆬᛯᕈ࡮ᵴᕈߩ㜞޿ൻว‛ߩഃ⵾ߦᚑഞߒߡ߅ࠅ㧘PET ࠻࡟࡯ࠨ࡯ൻ߽ᬌ⸛ߒߡ޿ࠆ‫ޕ‬8㧕⿥ㆬᛯᕈ Rho ࠠ࠽࡯࠯㒖ኂ೷ߩ PET ࠻࡟࡯ࠨ࡯ൻ
ㆃ⊒ᕈ⣖ⴊ▤ᡨ❗㑐ㅪ⿥ㆬᛯ⊛ Rho ࠠ࠽࡯࠯㒖ኂ೷㧔H1152㧕߇ࡊࡠࠬ࠲ࠣ࡜ࡦࠫࡦฃኈ૕ EP3 ૞േ⮎ߦࠃࠆ NO ↥↢ࠍ㒖ኂߒ㧘Ἳ∝ᕈ−∩߿␹⚻࿃ᕈ−∩ࠍᛥ೙ߔࠆߎߣ߇ࠊ߆ߞߚ‫⮎ߩߎޕ‬೷ߩ␹⚻࿃ᕈ−∩ߦኻߔࠆലᨐࠍಽሶ࡟ࡌ࡞ߢᬌ⸽ߒ㧘∩ߺߩ⸻ᢿ޽ࠆ޿ߪᴦ≮⮎ߦᔕ↪ߔࠆߚ߼ PET ࡊࡠ࡯ࡉൻࠍ
ⴕߥߞߡ޿ࠆ‫ޕ‬
2㧚ฬ★
ಎᢎ᝼㧦 ฎ↰੨ผഥᢎ㧦ฎጊᶈሶ

Kyoji Furuta
Hiroko Koyama

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
ߥߒ⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
ߥߒ✚⺑㧔᰷ᢥ㧕
ߥߒේ⪺㧔๺ᢥ㧕
ߥߒේ⪺㧔᰷ᢥ㧕
1㧕 Satoh T, Okamoto S.-i, Cui J, Watanabe Y, Furuta K, Suzuki M, Tohyama K, S. A. Lipton. Activation of
the Keap1/Nrf2 Pathway for Neuroprotection by Electrophilic Phase II Inducers. Proc Natl Acad Sci
USA. 2006;103:768-773.
2㧕 Sun P, Wang G. X, Furuta K, Suzuki M. Synthesis of a Bis-Azido Analogue of Acromelic Acid forRadioisotope-Free
Photoaffinity Labeling and Biochemical Studies. Bioorg Med Chem Lett.
2006;16:2433-2436.
3㧕 Kaneko S, Ando A, Okuda-Ashitaka E, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S. Ornithine
Transport Via Cationic Amino Acid Transporter-1 Is Involved in Ornithine Cytotoxicity in Retinal
Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2007;48:464-471.
4㧕 Furuta K, Maeda M, Hirata Y, Shibata S, Kiuchi K, Suzuki M. Synthesis of Neuroprotective
Cyclopentenone Prostaglandin Analogs: Suppression of Manganese-induced Apoptosis of PC12 Cells.
Bioorg Med Chem Lett. 2007;17:5487-5491.
5㧕 Kaneko S, Okuda-Ashitaka E, Ando A, Nishimura K, Igarashi K, Suzuki M, Matsumura M, Ito S.
Polyamines Upregulate the mRNA Expression of Cationic Amino Acid Transporter-1 in Human
Retinal Pigment Epithelial Cells. Am J Physiol Cell Physiol. 2007;293:C729-C737.
6㧕 Soen M, Minami T, Tatsumi S, Mabuchi T, Furuta K, Maeda M, Suzuki.M, Ito S. A Synthetic Kainoid,(2S,3R,4R) -3-Carboxymethyl-4- (Phenylthio) Pyrrolidine-2-Carboxylic Acid (PSPA-1) Serves as a
Novel Anti-Allodynic Agent for Neuropathic Pain. Eur J Pharmacol. 2007;575:75-81.
7) Hao HL, Sun P, Wang GX, Furuta K, Suzuki M. Synthesis of Both Epimeric Triacid Analogs of Kainic
Acid. Chinese Chem Lett. 2008;19:269-272.

㧙㧙

IF 9.598

IF 2.604

IF 3.528

IF 2.604

IF 4.230

IF 2.376

4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦⪤ේᱜᢅ㧔᧲੩ක⑼ᱤ⑼ᄢቇ㧕㧘⎇ⓥಽᜂ⠪㧦ฎጊᶈሶ㧘㋈ᧁᱜᤘ㧘੗਄ᢅ㧧଻ஜක≮
ಽ㊁ߦ߅ߌࠆၮ␆⎇ⓥផㅴ੐ᬺ⎇ⓥࡊࡠࠫࠚࠢ࠻㧧SR Ⱞ⊕࡝ࡦ㉄ൻ㉂⚛㒖ኂᵴᕈࠍ᦭ߔࠆᣂߒ޿᛫
࠙ࠖ࡞ࠬൻว‛ߩวᚑߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 16㧙20 ᐕᐲ㧧25,000 ජ౞(6,000㧦6,000㧦5,000㧦4,000㧦
4,000 ජ౞)2㧕 ⎇ⓥઍ⴫⠪㧦ฎ↰੨ผ㧘⎇ⓥಽᜂ⠪㧦ᐔ↰ᵗሶ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦␹⚻⚦⢩଻⼔૞↪ࠍ␜ߔᣂⷙࠪࠢࡠࡍࡦ࠹ࡁࡦಽሶࡊࡠ࡯ࡉߩഃ⵾ߣᵴ↪㧧ᐔᚑ 17㧙19 ᐕᐲ㧧12,500 ජ
౞(5,700㧦3,800㧦3,000 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦ฎ↰੨ผ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄⪚⧘⎇ⓥ㧦∩ߺߩࠗࡔ࡯ࠫࡦࠣߦะߌߚࡊࡠ
࡯ࡉಽሶߩ⸳⸘㧧ᐔᚑ 18㧙19 ᐕᐲ㧧3,300 ජ౞(1,400㧦1,900 ජ౞)
4㧕 ⎇ⓥઍ⴫⠪㧦ฎ↰੨ผ㧘⎇ⓥಽᜂ⠪㧦⷏Ỉᐙ㓶㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄․ቯ㗔ၞ⎇ⓥ ౏൐⎇ⓥ㧦∩ⷡߦ㑐ࠊࠆࠕࠢࡠࡔ࡝ࡦ㉄ฃኈ૕ត⚝ࡊࡠ࡯ࡉߩഃ⵾㧦ᐔᚑ 18㧙20 ᐕᐲ㧧8,500 ජ౞(3,200㧦2,600㧦2,700 ජ౞)
5㧕 ⎇ⓥઍ⴫⠪㧦ฎ↰੨ผ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦ࠕࡠ࠺ࠖ࠾ࠕ⺃⊒ߦ߆߆ࠊࠆᣂ
ⷙฃኈ૕ߩត⚝ࡊࡠ࡯ࡉߩഃ⵾㧧ᐔᚑ 20㧙22 ᐕᐲ㧧13,900 ජ౞(5,300㧦4,800㧦3,800 ජ౞)
2㧕ฃ⸤⎇ⓥ1㧕 ฎጊᶈሶ㧧⣖⣲≌ߩࠕ࡞ࠠ࡞ൻ᛫≸೷⠴ᕈ࠲ࡦࡄࠢᵴᕈߩ PET ࠗࡔ࡯ࠫࡦࠣ⸻ᢿߩ㐿⊒㧧ᐔᚑ 20
㧙21 ᐕᐲ㧧3,055 ජ౞(975 ජ౞㧦2,080 ජ౞)㧦JST
3㧕౒ห⎇ⓥ1㧕 ฎ↰੨ผ㧦ಽሶࡊࡠ࡯ࡉߩวᚑߣᯏ⢻⹏ଔߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 19㧙20 ᐕᐲ㧦ℂൻቇ⎇ⓥᚲ
2㧕 ฎ↰੨ผ㧘ᐔ↰ᵗሶ㧦ᣂⷙ␹⚻଻⼔⮎ߩ⎇ⓥ㧧ᐔᚑ 19 ᐕᐲ㧧100 ජ౞㧦ද๺㉙㉂Ꮏᬺ(ᩣ)
3㧕 ฎጊᶈሶ㧦ක⮎ຠ╬ߦ᦭ᦸߣ⠨߃ࠆ࡝ࡦ㉄ൻ㉂⚛㒖ኂ૞↪╬૗ࠄ߆ߩ↢ℂᵴᕈࠍ᦭ߔࠆൻว‛ߦ㘃✼ߒ‫ߪߚ߹ޔ‬ห᭽ߩ૞↪ࠍ᦭ߔࠆߎߣ߇ᦼᓙߐࠇࠆૐಽሶൻว‛ࠍวᚑߒ‫ޔ‬ක⮎ຠ╬ߣߒߡ㐿⊒ߔࠆߎߣ߇᦭ᦸߥ߽ߩࠍត⚝ߔࠆ㧧ᐔᚑ 20 ᐕᐲ㧧1,000 ජ౞㧦㧔ᩣ㧕ࠠࡁࡈࠔ࡯ࡑ
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫ
1㧕 ㋈ᧁᱜᤘ㧘ฎ↰੨ผ㧘દ⮮⺈ੑ㧘ධᢅ᣿㧦ࡊࡠ࡝ࡦ㘃✼૕㧧ᐔᚑ 18 ᐕ(․㗿 2005㧙347711)
2㧕 ㋈ᧁᱜᤘ㧘ฎ↰੨ผ㧘દ⮮⺈ੑ㧘ධᢅ᣿㧦␹⚻࿃ᕈ−∩ࠍᛥ೙ߔࠆᣂⷙࡆࡠ࡝ࠫࡦ㘃✼૕߅ࠃ߮ߘ
ߩ⵾ㅧᣇᴺ㧧ᐔᚑ 19 ᐕ(․㗿 2006-157874, PCT/JP2007/60489, WO2007/142028)
6㧚ቇળᵴേ
1㧕ቇળᓎຬ
ߥߒ
2㧕ቇળ㐿௅
ߥߒ
3㧕ቇⴚ㔀⹹
ߥߒ
7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳ฎ↰੨ผ㧦
1㧕 ᣣᧄൻቇળ᧲ᶏᡰㇱ ᧲ᶏࠦࡦࡈࠔ࡟ࡦࠬ 2007㧙ഃ⮎࡮ක⮎߳ߩൻቇ߆ࠄߩ᜸ᚢ̆(ᐔᚑ 19 ᐕ 9 ᦬㧘ጘ㒂㧘ଐ㗬⻠Ṷ‫ࠕ࠾ࠖ࠺ࡠࠕޟ‬ᛥ೙ൻว‛ߩഃ⵾‫ޠ‬Ṷ⠪)ฎጊᶈሶ㧦
1㧕 ಽሶࠗࡔ࡯ࠫࡦࠣ⎇ⓥࠪࡦࡐࠫ࠙ࡓ 2008㧘‫␠ޟ‬ળߩ࠾࡯࠭ߦะߌߚಽሶࠗࡔ࡯ࠫࡦࠣ⎇ⓥߩዷ㐿‫(ޠ‬ᐔ
ᚑ 20 ᐕ 1 ᦬㧘᧲੩㧘᧲੩࿖㓙ࡈࠜ࡯࡜ࡓ㧘Poster Session‫ޟ‬㔍ᴦᗵᨴ∝ߦኻߔࠆᣂⷙᴦ≮⮎㐿⊒ߩߚ߼ߩࠗࡔ࡯ࠫࡦࠣ⎇ⓥ‫ޠ‬Ṷ⠪)㧙㧙8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫߥߒ9㧚␠ળᵴേฎ↰੨ผ㧦
1㧕 ᣣᧄቇⴚᝄ⥝ળ⑼ቇ⎇ⓥ⾌ᆔຬળኾ㐷ᆔຬ(ᐔᚑ 18㨪19 ᐕᐲ)
10㧚ႎ๔ᦠ
1㧕 ฎ↰੨ผ㧦␹⚻⚦⢩଻⼔૞↪ࠍ␜ߔᣂⷙࠪࠢࡠࡍࡦ࠹ࡁࡦಽሶࡊࡠ࡯ࡉߩഃ⵾ߣᵴ↪㧦ᐔᚑ 17 ᐕᐲ
㧙19 ᐕᐲ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ၮ⋚⎇ⓥ(B)⎇ⓥᚑᨐႎ๔ᦠ(2008 ᐕ 5 ᦬)
11㧚ႎ㆏1㧕 ฎ↰੨ผ㧦⮎ߩ↢૕ౝߢߩേ߈ࠍㅊ〔㧦 ጘ㒂ᣂ⡞(2008 ᐕ 10 ᦬ 21 ᣣ)
12㧚⥄Ꮖ⹏ଔ
⹏ଔ⎇ⓥ㕙ߢߪ㧘⑼ቇ⎇ⓥ⾌ߦࠃࠆၮ␆⎇ⓥࠍਛᔃߦⴕߞߡ޿ࠆ߇㧘ታ↪ൻߦะߌߚ․⸵߽ขᓧߒߡ߅ࠅ
㧔࿖㓙․⸵ߢ JST ࠃࠅ 7 ࠞ࿖⒖ⴕߩᡰេࠍฃߌߚ㧕㧘㔍ᴦᕈ∔ᖚߩᴦ≮⮎୥⵬ߣߒߡᵈ⋡ࠍ㓸߼ߡ޿ࠆ‫ޕ‬ߎࠇࠄਥⷐ⎇ⓥ࠹࡯ࡑߢߩ․⸵಴㗿ߩߚ߼㧘⺰ᢥ߿ቇળ⊒⴫╬ࠍប߃ߡ޿ߚ߇㧘಴㗿ߩᷣࠎߛ߽ߩߦ㑐ߒߡߪ⺰ᢥߣߒߡߢ߈ࠆ㒢ࠅᣧߊᚑᨐࠍ౏⴫ߒߡ޿ߊ੍ቯߢ޽ࠆ‫ࠆ߈ߢ⴫౏ޕ‬ᚑᨐߦ㑐ߒߡߪ࿖ౝ࡮࿖
㓙ቇળߢᲤᐕ⊒⴫ߒߡ޿ࠆ‫ޕ‬ᄖㇱ⾗㊄ߢߪ⑼ቇ⎇ⓥ⾌ࠍᲤᐕ₪ᓧߒߡ޿ࠆ‫ߦࠄߐޕ‬㧘⽷࿅ߩ⎇ⓥ⾌߿ડᬺ߆ࠄߩ⾗㊄₪ᓧߦะߌߡ㧘․⸵ࠍ߽ߣߦߒߚ౒ห⎇ⓥࠍㅴ߼ࠆ⸘↹ߢ޽ࠆ‫੹ޕ‬ᓟ߽ቇⴚ⊛ߥ⎇ⓥࠍផ
ㅴߔࠆߣߣ߽ߦߘߩᚑᨐࠍ␠ળߦㆶరߦߒߡ޿߈ߚ޿‫ޕ‬ቇ↢ߩ⎇ⓥᜰዉ࡮ᢎ⢒㕙ߢߪ࿖ౝᄖߩቇળ⊒⴫ߩઁ㧘ઁᄢቇ߿ℂൻቇ⎇ⓥᚲߣߩ౒ห⎇ⓥߦෳടߐߖࠆߥߤ㧘ᣂᛛⴚߦኻᔕߢ߈ࠆቇ㓙࡮࿖㓙⊛⎇ⓥ࡮ᛛⴚ⠪ߩ⢒ᚑߦะߌߡദജߒߡ޿ࠆ‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷ᐔᚑ 17 ᐕ 9 ᦬ࠃࠅ㋈ᧁᱜᤘᢎ᝼߇ℂൻቇ⎇ⓥᚲࡈࡠࡦ࠹ࠖࠕ⎇ⓥࠪࠬ࠹ࡓಽሶࠗࡔ࡯ࠫࡦࠣࡊࡠࠣ࡜
ࡓ࡮࠴࡯ࡓ࡝࡯࠳࡯౗છߣߥࠅ㧘ᐔᚑ 20 ᐕ 4 ᦬ߦหኾછߣߒߡℂൻቇ⎇ⓥᚲߦォ಴ߣߥߞߚߚ߼⎇ⓥቶⷙᮨ߇❗ዊߒߡ޿ࠆ‫⃻ޕ‬࿷㧘ᧄಽ㊁ߢߪකቇ♽⎇ⓥ⑼ඳ჻೨ᦼ⺖⒟ߩቇ↢ߣᎿቇㇱ↢๮Ꮏቇ⑼ߩත⎇↢㧔4 ᐕ↢㧕߅ࠃ߮ഃ⮎ක≮ᖱႎ⎇ⓥ⑼ߩඳ჻ᓟᦼ⺖⒟ߩቇ↢ߩ⎇ⓥᜰዉࠍⴕߞߡ޿ࠆ‫ߩߢ߹ࠇߎޕ‬ඳ჻೨ᦼ⺖⒟ߩቇ↢ߪ 100%߇↢๮Ꮏቇ⑼߆ࠄ㈩ዻߐࠇߚත⎇↢ߩㅴቇߦࠃࠆ߽ߩߢ޽ࠅ㧘ઁᄢቇ߆ࠄߩ౉
ቇ⠪ߪ޿ߥ޿‫ޕ‬Ꮏቇㇱ߆ࠄߩ㈩ዻත⎇↢ߩᢙߪ⡯ຬ᭴ᚑߦࠃࠅ᳿߹ࠆߚ߼ᓥ᧪ߣᲧߴඨᷫߒߡ޿ࠆߎߣ
߆ࠄ㧘੹ᓟඳ჻೨ᦼ⺖⒟ߩቇ↢ᢙߩᷫዋ߇⷗ㄟ߹ࠇࠆ‫↢ޕ‬๮Ꮏቇ⑼ߦ߅޿ߡ߽ൻቇ♽ࠍᔒᦸߔࠆቇ↢ᢙ߇ᷫߞߡ߅ࠅ㧘ቇㇱᢎ⢒ߩᲑ㓏ߦ߅޿ߡᎿቇㇱߣߩㅪ៤ࠍᒝൻߔࠆᔅⷐ߇޽ࠆ‫ߚ߹ޕ‬㧘ઁᄢቇ╬߆ࠄߩቇ↢൐㓸߽Ⓧᭂ⊛ߦⴕ߁ᔅⷐ߇޽ࠆߣ⠨߃ߡ޿ࠆ‫⎇ޕ‬ⓥ㕙ߢ߽㧘ㅴⴕਛߩࡊࡠࠫࠚࠢ࠻ߩਥജ⵬ഥຬߣ
ߥࠆᄢቇ㒮↢ߩ⏕଻߇⺖㗴ߢ޽ࠆ‫ޕ‬੹ᓟߩዷᦸ࿖㓙․⸵ࠍขᓧߒߚ␹⚻࿃ᕈ−∩ᛥ೙೷ߩᴦ≮⮎ߣߒߡߩ㐿⊒ߦะߌߡ೨⥃ᐥ⹜㛎߳ߩዷ㐿ࠍ⋡ᜰߔ‫ޕ‬␹⚻⚦⢩ᱫᛥ೙೷ߦߟ޿ߡ߽ጘ㒂ᄢቇߩᡰេ߇᳿ቯߒߡ߅ࠅ㧘․⸵಴㗿ࠍߢ߈ࠆ㒢ࠅᣧߊⴕ߁‫ߚ߹ޕ‬㧘ߎࠇࠄൻว‛ߩ PET ࡊࡠ࡯ࡉൻߣಽሶࠗࡔ࡯ࠫࡦࠣߦࠃࠆᦨవ┵ഃ⮎⎇ⓥࠍផㅴߒߚ޿‫ߦࠄߐޕ‬㧘ᢎ⢒㕙ߢ߽ࠃࠅ߈߼⚦߆ߥᜰዉ૕೙ࠍ⏕┙ߒ㧘ၮ⋚ߣߥࠆวᚑᛛⴚߣචಽߥၮ␆ቇജࠍ஻߃ߚഃㅧᕈ⼾߆ߥቇ↢ࠍ⢒ᚑߒߚ޿‫ޕ‬㧙㧙㧔2㧕⍮⢻ࠗࡔ࡯ࠫᖱႎಽ㊁1㧚⎇ⓥߩ᭎ⷐ
ౣ↢ක⑼ቇኾ᡹ౣ↢Ꮏቇ⻠ᐳ⍮⢻ࠗࡔ࡯ࠫᖱႎಽ㊁ߢߪ㧘ࠦࡦࡇࡘ࡯࠲ࠍ㚟૶ߒߡක↪↹௝ᖱႎࠍ޿ࠈ
޿ࠈߥⷺᐲ߆ࠄಣℂ࡮ടᎿߒ㧘ౣ↢කቇࠍߪߓ߼᭽‫ߥޘ‬ක≮ಽ㊁ߦ߅ߌࠆ↹௝ᖱႎࠍขࠅᛒߞߚᢎ⢒࡮⎇ⓥࠍⴕߞߡ޿ࠆ‫߫߃଀ޕ‬㧘ࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔computer-aided diagnosis, CAD㧕ߣ๭߫ࠇࠆ߇㧘↹௝਄ߩ∛ᄌߩ૏⟎ࠍࠦࡦࡇࡘ࡯࠲ಣℂߢᜰ៰ߒ㧘޽ࠆ޿ߪ∛ᄌㇱ૏ߩࠦࡦࡇࡘ࡯࠲ߦࠃࠆቯ㊂⊛ߥಽᨆᖱႎࠍකᏧߦឭଏߔࠆߎߣߦࠃߞߡ㧘ࠃࠅᱜ⏕ߢ⏕ታߥකᏧߩ↹௝⸻ᢿ߇ⴕ߃ࠆࠃ߁ߦᡰេߔࠆࠪࠬ࠹ࡓߩ
㐿⊒ߢ޽ࠆ‫ޕ‬ℂᎿቇ♽⎇ⓥ⠪ߣකᏧ߿ࠦ࡮ࡔ࠺ࠖࠞ࡞ࠬ࠲࠶ࡈߣߩ᦭ᯏ⊛ߥ౒ห⎇ⓥ߇․ᓽߢ޽ࠆ‫↹ޕ‬௝
ᖱႎಣℂ㧘ࡃ࡯࠴ࡖ࡞࡝ࠕ࡝࠹ࠖ㧔VR㧘઒ᗐ⃻ታ㧕㧘ੱᎿ⍮⢻ߥߤߩᦨవ┵ߩᎿቇᛛⴚߩᢎ⢒ࠍⴕ޿㧘߹ߚකᎿቇ⊛ߥቇ㓙㗔ၞߩ↹௝⎇ⓥߦᔕ↪ߔࠆ‫߅ߥޕ‬㧘⎇ⓥቶߩ⹦⚦߿⎇ⓥౝኈߥߤߦߟ޿ߡߪ㧘⎇ⓥቶߩ
ࡎ࡯ࡓࡍ࡯ࠫߦឝタߒߡ޽ࠆ㧔http://www.fjt.info.gifu-u.ac.jp/㧕‫ᧄޕ‬ಽ㊁ߩᦨㄭߩ㊀ὐ⊛ߥ⎇ⓥ⺖㗴ߢ޽ࠆ CAD ⎇ⓥߩ᭎ⷐߦߟ޿ߡ㧘એਅߦ◲නߦ⺑᣿ߔࠆ‫ޕ‬
1㧕3 ߟߩ↹௝⸻ᢿ㗔ၞߦ߅ߌࠆࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕ࠪࠬ࠹ࡓߩታ↪ൻ⎇ⓥ
ᧄ⎇ⓥߪ㧘ᐔᚑ 16 ᐕᐲ߆ࠄ 5 ᐕ⸘↹ߢណ↪ߐࠇጘ㒂࡮ᄢ၂࿾ၞߢᆎ߹ߞߚᢥㇱ⑼ቇ⋭ߩ⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ⎇ⓥߦࠃࠆ⎇ⓥ㧔ࡠࡏ࠹ࠖ࠶ࠢవ┵ක≮ࠢ࡜ࠬ࠲࡯㧕ߢ޽ࠆ㧔http://www.cluster-g.jp/what.html㧕
‫ޕ‬⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ੐ᬺߣߪ㧘࿾ᣇ⥄ᴦ૕ߩਥ૕ᕈࠍ㊀ⷞߒ㧘⍮⊛ഃㅧߩ᜚ὐߚࠆᄢቇ㧘౏⊛⎇ⓥᯏ㑐╬ࠍᩭߣߒߚ㑐ㅪ⎇ⓥᯏ㑐㧘⎇ⓥ㐿⊒ဳડᬺ╬ߦࠃࠆ࿖㓙⊛ߥ┹੎ജߩ޽ࠆᛛⴚ㕟ᣂߩߚ߼ߩ㓸Ⓧߩഃᚑࠍ⋡ᜰߔᢥㇱ⑼ቇ⋭ߩ੐ᬺߢ޽ࠆ㨫ᧄቇߦ߅޿ߡ߽㧘ਛᦼ⸘↹ߢขࠅ਄ߍࠄࠇߡ޿ࠆ㊀ⷐ⎇ⓥࡊࡠࠫࠚࠢ࠻
ߢ޽ࠆ‫ޕ‬3 ߟߩࡔࠗࡦࡊࡠࠫࠚࠢ࠻㧔ૐଚⷅᓸ⚦ᚻⴚᡰេ࡮ᢎ⢒⸠✵ࠪࠬ࠹ࡓߩ㐿⊒㧘ක≮⸻ᢿᡰេࠪࠬ
࠹ࡓߩ㐿⊒㧘߅ࠃ߮ක≮੺⼔ᡰេࠪࠬ࠹ࡓߩ㐿⊒㧕߇ㅴⴕਛߢ޽ࠅ㧘ᧄ⎇ⓥቶߢߪ㧘ක≮⸻ᢿᡰេࠪࠬ࠹
ࡓߩਛߢ㧘‫↹ޟ‬௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒‫ࠍޠ‬ᜂᒰߒߡ޿ࠆ‫ޕ‬⃻࿷㧘⣖ MR ↹௝㧘੃⣼⿥㖸ᵄ↹௝㧘߅ࠃ߮⌒ᐩ↹௝ߩߚ߼ߩ CAD ࠪࠬ࠹ࡓߩ㐿⊒ࠍ㧘ᧄቇ㒝ዻ∛㒮ࠍೋ߼ߣߒߚ⋵ౝᄖߩකቇ♽㑐ଥ⠪㧘⋵ౝߩᛛⴚ♽ᄢቇ㧘߅ࠃ߮⋵ౝᄖߩⶄᢙߩડᬺߣ౒ห⎇ⓥࠍⴕߞߡ޿ࠆ‫⋡ޕ‬ᮡࠍ㆔߆ߦ਄࿁ࠆ․⸵ൻ㧘⺰ᢥൻ߇㗅⺞ߦㅴࠎߢ߅ࠅ㧘㐿⊒ࠪࠬ࠹ࡓߩⶄᢙߩ੐ᬺൻ㧔໡ຠൻ㧕߽㗅⺞ߦ㆐ᚑਛߢ㧘ᄖㇱ⹏ଔᆔຬળ߆ࠄߪᏱߦᦨ㜞ߩ⹏ଔࠍ޿ߚߛ޿ߡ޿ࠆ㨫
2㧕૕ᐙㇱ X ✢ CT ↹௝ߩߚ߼ߩࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕ࠪࠬ࠹ࡓߩ㐿⊒⎇ⓥߎߩࡊࡠࠫࠚࠢ࠻ߢߪ㧘૕ᐙㇱ㗔ၞߦ߅ߌࠆੱ૕⤳ེ╬ߩᱜᏱ᭴ㅧߩ⥄േ⸃ᨆߩ㐿⊒ࠍផㅴߒߡ߅ࠅ㧘ᱜᏱ᭴ㅧߩℂ⸃࡮⹺⼂ߩⷰὐ߆ࠄߩࠕࡊࡠ࡯࠴ߦ⌕⋡ߒߚ CAD ⎇ⓥߢ޽ࠆ‫ߪࡑ࡯࠹ߩߎޕ‬㧘ᐔᚑ 15 ᐕ㧔ᐔᚑ 15 ᐕᐲᐲ⊒⿷ߩᢥㇱ⑼ቇ⋭ߩ⑼ቇ⎇ⓥ⾌⵬ഥ㊄࡮․ቯ⎇ⓥ㗔ၞ‫ޟ‬ᄙᰴరක↪↹௝ߩ⍮⊛⸻ᢿᡰេ‫ޠ‬㨪ᐔᚑ 18 ᐕᐲ㧕ߦ߅ߌࠆ⸘↹⎇ⓥ࠹࡯ࡑߦណ↪ߐࠇ㧘4 ᐕ㑆ߦࠊߚߞߡ⺰ᢥൻࠍਛᔃߦᄙᄢߥᚑᨐࠍ᜼
ߍߚ‫⎇ᧄޕ‬ⓥߢ㐿⊒ߒߚฦ⤳ེߩ⥄േ⹺⼂࡮᛽಴ᚻᴺߪ㧘CAD ߳ߩᔕ↪ߩߺߥࠄߕ㧘ฦ⒳⎇ⓥࡊࡠࠫࠚࠢ࠻߳ߩ੹ᓟߩዷ㐿߽น⢻ߢ޽ࠆ‫߅ߥޕ‬㧘ห․ቯ㗔ၞ࠹࡯ࡑߪ㧘ᐔᚑ 19 ᐕᐲߦⴕࠊࠇߚ⚳ੌ⹏ଔߢ㧘ᦨ㜞૏ߩ⹏ଔࠍฃߌߡ޿ࠆ‫ޕ‬
3㧕੃߇ࠎ↹௝⸻ᢿߩߚ߼ߩࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕ࠪࠬ࠹ࡓߩ㐿⊒⎇ⓥߎߩࡊࡠࠫࠚࠢ࠻ߪߔߢߦ 1995 ᐕ߆ࠄ 10 ᐕ㑆એ਄ࠊߚࠅડᬺߣߩ౒ห⎇ⓥࠍⴕߞߡ߅ࠅ㧘ㄭ‫ޘ‬㧘CAD
ࠪࠬ࠹ࡓ߇໡ຠߣߒߡታ↪ൻߐࠇࠃ߁ߣߒߡ޿ࠆ㧔౒ห⎇ⓥవડᬺࠃࠅ⮎੐⹺น↳⺧ਛ㧕‫ޕ‬㓸࿅ᬌ⸻߿♖ኒᬌᩏߢ੃߇ࠎߩ↹௝⸻ᢿߢ೑↪ߐࠇࠆ੃ᚱ X ✢↹௝ߦ߅ߌࠆ߇ࠎ୥⵬㒶ᓇߩ૏⟎ࠍࠦࡦࡇࡘ࡯࠲ߩ⸃
ᨆ⚿ᨐߦࠃࠅ⍫ශߥߤߢ↹௝਄ߦᜰ៰ߒ㧘කᏧߩ⺒ᓇߩᱜ⏕ᐲߣߩะ਄߿⸻ᢿ⚿ᨐߩࡃ࡜࠷ࠠߩᷫዋ㧘ߐࠄߦ↢↥ᕈߩะ਄㧔⸻ᢿᤨ㑆ߩ⍴❗㧕ߥߤࠍ⋡⊛ߣߡ޿ࠆ‫ߚ߹ޕ‬㧘ᬌ಴ߐࠇߚ୥⵬ߩ⦟ᖡᕈߩ㐓೎ಣℂ㧘
୥⵬㒶ᓇߩ⸃ᨆ⚿ᨐឭ␜ᯏ⢻㧘࠺ࠖࠬ࠻࡯࡚ࠪࡦ∛ᄌߩᬌ಴ㅊടᯏ⢻ߥߤߦߟ޿ߡ߽㧘㐿⊒ࠍ⛯ߌߡ޿ࠆ‫ޕ‬ߥ߅㧘࠺ࡦࠬࡉ࡟ࠬ࠻߇ᄙ޿ᧄ㇌ᅚᕈ੃ᚱߩᬌ⸻ߩߚ߼ߦߪ㧘⿥㖸ᵄ↹௝߽⦟ߊ೑↪ߐࠇߡ޿ࠆߚ߼㧘਄⸥ 1㧕ߩ⍮⊛ࠢ࡜ࠬ࠲࡯ࡊࡠࠫࠚࠢ࠻ߢߪ㧘੃⣼ 3 ᰴర⿥㖸ᵄ↹௝ߩߚ߼ߩ CAD ࠪࠬ࠹ࡓߩ㐿⊒߽ⴕߞߡ޿ࠆ‫ޕ‬
4㧕ߘߩઁ਄⸥એᄖߦ߽㧘MRI ↹௝ߦ߅ߌࠆ⢄⤳∔ᖚߩ⥄േᬌ಴߿⸃ᨆߩߚ߼ߩ CAD ⎇ⓥ㧘PET ߦ߅ߌࠆ߇ࠎ
∛ᄌᬌ಴ߩߚ߼ߩ CAD ⎇ⓥ㧘ᢇᕆක≮ߩߚ߼ߩ↹௝ᡰេ⸻ᢿߩߚ߼ߩ CAD ⎇ⓥߥߤߦߟ޿ߡ㧘ቇౝᄖߩᄙߊߩ౒ห⎇ⓥ⠪ߣߣ߽ߦ⎇ⓥ㐿⊒ࠍⴕߞߡ޿ࠆ‫߅ߥޕ‬㧘੃߇ࠎ↹௝⸻ᢿߩߚ߼ߩ CAD ߦߟ޿ߡߪෘ
↢ഭ௛⋭ߩ߇ࠎ⎇ⓥഥᚑ㊄࡮⍹ᯅ⃰⎇ⓥࡊࡠࠫࠚࠢ࠻㧔࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖߦࠃࠆ੃߇ࠎᬌ⸻ߩല₸෸߮♖ᐲะ਄࡮⹏ଔߦ㑐ߔࠆ⎇ⓥ㧕ߣㅪ៤ߒߡ߅ࠅ㧘߹ߚ㧘ฦ⒳ߩ߇ࠎ↹௝⸻ᢿߩߚ߼ߩ CAD ࠪࠬ࠹ࡓߩ㐿⊒ߪ㧘ห⋭ߩ߇ࠎ⎇ⓥഥᚑ㊄࡮㐳⼱Ꮉ⃰⎇ⓥࡊࡠࠫࠚࠢ࠻‫↹࡞࠲ࠫ࠺ޟ‬௝ಣℂߦࠃࠆ߇ࠎ⸻ᢿᡰេࠪ
ࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ‫ߣޠ‬ㅪ៤ߒߡ⎇ⓥᵴേࠍⴕߞߡ޿ࠆ‫ޕ‬

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ಎᢎ᝼㧦 ේ ᱞผ
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Hiroshi Fujita
Takeshi Hara
Xiangrong Zhou

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
1㧕 ⮮↰ᐢᔒ㧚CAD ࠪࠬ࠹ࡓߩᎿቇ⊛ⷰὐ߆ࠄߩ⃻⁁㧙ᛛⴚ⊛೔㆐ὐߣ੹ᓟ߳ߩ⺖㗴㧘ߘߒߡᧂ᧪̆㧦᦬ೀᣂක≮࠺࡯࠲ࡉ࠶ࠢ࡮ࠪ࡝࡯࠭ ක≮ᯏེࠪࠬ࠹ࡓ⊕ᦠ 2006㨪2007㧘᧲੩㧦㧔ᩣ㧕ࠛࡓ࡮ࠗ࡯ᝄ⥝දળ㧧2006
ᐕ㧦275㧙281㧚
2㧕 ⮮↰ᐢᔒ㧚࠺ࠫ࠲࡞ࡑࡦࡕߣ CAD㧘ታ〣 ࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖ-ၮ␆߆ࠄ⸻ᢿ߹ߢ㧔✬㓸㧦ᄢౝᙗ᣿㧕㧘᧲੩㧦ਛጊᦠᐫ㧧2006 ᐕ㧦42㧙50㧚
3㧕 ⮮↰ᐢᔒ㧚X ✢↹௝ߩᒻᚑ㧦ක↪↹௝ᖱႎቇ㧔ᡷ⸓ 2 㧘᩵Ꮉ⨃ᒾ ✬⪺㧕㧘᧲੩㧦ධጊၴ㧧2006 ᐕ㧦27
㧙51㧚
4㧕 ⮮↰ᐢᔒ㧚ࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕㧙੃ᚱ X ✢౮⌀ߩࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧙㧦ක↪↹௝ᖱႎቇ㧔ᡷ
⸓ 2 㧘᩵Ꮉ⨃ᒾ ✬⪺㧕㧘᧲੩㧦ධጊၴ㧧2006 ᐕ㧦191㧙208㧚
5㧕 ⮮↰ᐢᔒ㧚࠺ࠖࠫ࠲࡞↹௝ߩ⴫␜㧦࿑⸃ ⸻≮᡼኿✢ᛛⴚታ〣ࠟࠗ࠼㧙╙৻✢ߢᔅߕᓎ┙ߟ⍮⼂࡮ታ〣ߩߔߴߡ㧙㧔╙ 2 㧕㧘㜞ᯅᱜᴦ࡮㜞ᯅ 㓉 ✬㧘᧲੩㧦ᢥశၴ㧧2006 ᐕ㧦616㧙619㧚
6㧕 ⮮↰ᐢᔒ㧚ࡑࡦࡕࠣ࡜ࡈࠖߦ㑐ߔࠆࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕㧦࿑⸃ ⸻≮᡼኿✢ᛛⴚታ〣ࠟࠗ࠼㧙╙৻✢ߢᔅߕᓎ┙ߟ⍮⼂࡮ታ〣ߩߔߴߡ㧙㧔╙ 2 㧕㧘㜞ᯅᱜᴦ࡮㜞ᯅ 㓉 ✬㧘᧲੩㧦ᢥశၴ㧧2006 ᐕ㧦625
㧙628㧚
⪺ᦠ㧔᰷ᢥ㧕
1㧕 Fukuoka D, Hara T, Fujita H. Detection, characterization, and visualization of breast cancer using 3-D
ultrasound images. In: eds. Suri, JS and Rangayyan, RM. Recent Advances in Breast Imaging,
Mammography, and Computer-Aided Diagnosis of Breast Cancer, Chapter 16, Press Monograph
PM155, SPIE Press;2006:563-572.
2㧕 Matsubara T, Hara T, Fujita H. Automated detection for architectural distortions with retraction andspeculation on mammograms. In: eds. Suri JS, Rangayyan RM, and Laxminarayan S. Emerging
Technologies in Breast Imaging and Mammography, Chapter 24, American Scientific Publishers;
2008:463-469.
✚⺑㧔๺ᢥ㧕
1㧕 ⮮↰ᐢᔒ㧚CAD ߩታ↪ൻߣ᥉෸ߦะߌߡ㧘ᣂක≮ 2006 ᐕ㧧33 Ꮞ㧦95㧙102㧚
2㧕 ⮮↰ᐢᔒ㧚੃ᚱ᠟ᓇᛛⴚߩ⃻⁁ߣ዁᧪㧙੃ᚱ↹௝ಣℂᛛⴚ㧙㧘ᣣᧄ౮⌀ቇળ⹹ 2006 ᐕ㧧69 Ꮞ㧦16㧙22㧚
3㧕 ⮮↰ᐢᔒ㧚࠺ࠖࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖ⎇ⓥ߳ߩᦼᓙߣ⺖㗴㧘ᣣᧄ᡼኿✢ᛛⴚቇળ࡮↹௝ㅢା 2006 ᐕ㧧29Ꮞ㧦4㧙13㧚
4㧕 ේ ᱞผ㧘⮮↰ᐢᔒ㧚ࡑࡦࡕࠣ࡜ࡈࠖߦ߅ߌࠆ CAD ߩ⃻⁁ߣዷᦸ㧘Rad Fan 2006 ᐕ㧧4 Ꮞ㧦67㧙71㧚
5㧕 ๟ ะᩕ㧘⮮↰ᐢᔒ㧚૕ᐙㇱ㗔ၞߩන⚐ CT ↹௝ߦ߅ߌࠆ⸃೬ቇ⊛ᱜᏱ᭴ㅧߩ⹺⼂㧘Medical Imaging
Technology 2006 ᐕ㧧24 Ꮞ㧦167㧙172㧚
6㧕 ⮮↰ᐢᔒ㧘ේ ᱞผ㧘᧻ේ෹ሶ㧘⑔ጟᄢテ㧚੃߇ࠎ↹௝⸻ᢿ㗔ၞߦ߅ߌࠆࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕㧘੃ᚱ↹௝․㓸࡮᜗ᓙ⺰ᢥ㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2006 ᐕ㧧23 Ꮞ㧦19㧙26㧚
7㧕 ⮮↰ᐢᔒ㧚CAD ߩዷᦸ㧙ࡑࡦࡕࠣ࡜ࡈࠖߩ CAD㧘੃⣼⿥㖸ᵄ↹௝ߩ CAD㧘߅ࠃ߮੃⣼ MRI ߩ CAD㧘INNERVISION 2006 ᐕ㧧21 Ꮞ㧦38㧙42㧚
8㧕 ੳᧁ ⊓㧘⮮↰ᐢᔒ㧚ක↪↹௝ߩ⎇ⓥᦨ೨✢㧘㔚ሶᖱႎㅢାቇળᖱႎ࡮ࠪࠬ࠹ࡓ࠰ࠨࠗࠛ࠹ࠖ⹹ 2007 ᐕ㧧
12 Ꮞ㧦6㧙13㧚
9㧕 ⮮↰ᐢᔒ㧘ᖱႎಽ㊁ᜂᒰ ᣣᧄක↪‛ℂቇળ↪⺆ᆔຬળ✬㧚කቇ‛ℂ↪⺆㓸 2007㧘කቇ‛ℂ 2007 ᐕ㧧
27 Ꮞ㧚
10㧕 ኹᧄ◊ม, ጊ↰ቬ↵, ᧛⿧⾆ⴕ, ᵤဈ᣽೑, ⮮↰ᐢᔒ㧚௑ᢳဳ CT ࠍ↪޿ߚ㜞ኒᐲታⵝၮ᧼⸃ᨆ㧘ࠛ࡟ࠢ࠻ࡠ࠾ࠢࠬታⵝቇળ⹹ 2007 ᐕ㧧10 Ꮞ㧦528㧙532㧚
11㧕 ⮮↰ᐢᔒ㧚ක≮↹௝ߩࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧘․㓸ภ㧦ක≮ߣ੺⼔ࠍᡰេߔࠆᣂஜᐽࡈࡠࡦ࠹ࠖࠕ․㓸ภ㧘ࠪࠬ࠹ࡓ/೙ᓮ/ᖱႎ㧔ࠪࠬ࠹ࡓ೙ᓮቇળ⹹㧕 2007 ᐕ㧧51 Ꮞ㧦433㧙438㧚
12㧕 ⮮↰ᐢᔒ㧚ක≮↹௝⸻ᢿߣ࠺ࠖࠬࡊ࡟ࠗ㧘․㓸 2㧦ක≮ߣ࠺ࠖࠬࡊ࡟ࠗ㧘᦬ೀ࠺ࠖࠬࡊ࡟ࠗ 2007 ᐕ㧧13
Ꮞ㧦47㧙50㧚
13㧕 ⮮↰ᐢᔒ㧚ࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕ߩ⃻⁁᭎ⷰ㧘ᣣᧄ᡼኿✢ᛛⴚቇળ㔀⹹ 2007 ᐕ㧧63 Ꮞ㧦1389
㧙1395㧚
14㧕 ๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧚ᱜᏱ᭴ㅧߩℂ⸃ߦၮߠߊ⍮⊛ CAD㧘․㓸 CAD ᦨ೨✢ 2007㧦ᰴ਎ઍ CAD
ࠪࠬ࠹ࡓ߳ߩ᜸ᚢ㧔ᄙ⤳ེ࡮ᄙ∔∛ CAD ࠪࠬ࠹ࡓ㐿⊒ࡊࡠࠫࠚࠢ࠻ߩᚑᨐ㧕㧘INNERVISION 2007 ᐕ㧧
22 Ꮞ㧦21㧙25㧚
15㧕 ⮮↰ᐢᔒ㧚ᬌ⸻ߦ߅ߌࠆ CAD㧘ᢎ⢒⻠Ṷ㧘᡼኿✢᠟ᓇಽ⑼ળ⹹㧔ᣣᧄ᡼኿✢ᛛⴚቇળ㧕 2008 ᐕ㧧50 ภ㧦
3㧙6㧚
16㧕 ട⮮ඳၮ㧘౗᧻㓷ਯ㧘ㄭ⮮ᶈผ㧘੖ፉ ⡡㧘ᨷᬀ⵨੺㧘๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧚CAD ࠍ↪޿ߚ⢄㧙㧙⎬ᄌ∝ߩ MRI ⸻ᢿ㧘ᤋ௝ᖱႎ Medical 2008 ᐕ㧧40 Ꮞ㧦470㧙473㧚
17㧕 ਛᎹବ᣿㧘⮮↰ᐢᔒ㧚ࠬ࠹࡟ࠝ⌒ᐩࠞࡔ࡜ߣߪ㧫㧔․㓸㧦⥃ᐥᬌᩏࠍ⍮ߞߡ޿߹ߔ߆㧫㧕㧘Q㧒A ߢࠊ߆ࠆ⢈ḩߣ♧ዩ∛ 2008 ᐕ㧧7 Ꮞ㧦413㧙415㧚
18㧕 ේ ᱞผ㧚ࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕ߩၮ␆ 2㧚ⓨ㑆㗔ၞߢߩ↹௝ಣℂ㧘ᣣᧄ᡼኿✢ᛛⴚቇળ㔀⹹
2008 ᐕ㧧64 Ꮞ㧦638㧙646㧚
19㧕 ⮮↰ᐢᔒ㧚CAD ታ↪ൻ 10 ๟ᐕ㧙⥃ᐥ⃻႐߳ߩዉ౉ߩ⃻⁁ߣ⺖㗴㧙㧘ᣂක≮ 2008 ᐕ㧧35 Ꮞ㧦102㧙105㧚
20㧕 ๟ ะᩕ㧘⮮↰ᐢᔒ㧚㛽ᩰ࡮㛽ᩰ╭ߩ image-based model ߅ࠃ߮ CAD㧘․㓸‫ޟ‬㛽㑐▵↹௝⸻ᢿߩᦨ೨✢㧙MSK ࠍ❱ࠆ-‫ޠ‬㧘⥃ᐥ↹௝ 2008 ᐕ㧧24 Ꮞ㧦1361㧙1370㧚
21㧕 ⮮↰ᐢᔒ㧚੃ᚱ↹௝⸻ᢿ߳ߩ⸻ᢿᡰេߩ⠨߃ᣇߣ⃻⁁㧘ᤋ௝ᖱႎ Medical 2008 ᐕ㧧40 Ꮞ㧦1120㧙1126㧚
22㧕 ਛᎹବ᣿㧘⇌ਛ⵨ม㧘᧛᧻ජᏀሶ㧘⮮↰ᐢᔒ㧚⌒ᐩ↹௝ߩࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿߩ⃻⁁ߣ⺖㗴㧘⸃⺑㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2008 ᐕ㧧25 Ꮞ㧦70㧙77㧚✚⺑㧔᰷ᢥ㧕
1㧕 H. Fujita, Y. Uchiyama, T. Nakagawa, D. Fukuoka, Y. Hatanaka, T. Hara, Y. Hayashi, Y. Ikedo, G.N.
Lee, X. Gao, X. Zhou. CAD on brain, fundus, and breast images, eds. X.W. Gao, et al., Proc. ofInternational Conference on Medical Imaging and Informatics (MIMI2007), Middlesex University
Press, 2007;278-301 (skip 279-288).
2㧕 Fujita H, Uchiyama Y, Nakagawa T, Fukuoka D, Hatanaka Y, Hara T, Hayashi Y, Ikedo Y, Lee GN,
Gao X, Zhou X. CAD on brain, fundus, and breast images, Medical Imaging and Informatics, Lecture
Notes in Computer Science, Springer Berlin / Heidelberg, 2008;4987;358-366.
3㧕 Zhang X, Fujita H, Qin T, Zhao J, Kanematsu M, Hara T, Zhou X, Yokoyama R, Kondo H, Hoshi H.
CAD on liver using CT and MRI, Medical Imaging and Informatics, Lecture Notes in Computer
Science, Springer Berlin / Heidelberg. 2008;4987:367-376.
4㧕 Fujita H, Uchiyama Y, Nakagawa T, Fukuoka D, Hatanaka Y, Hara T, Lee GN, Hayashi Y, Ikedo Y,
Gao X, Zhou X. Computer-aided diagnosis: The emerging of three CAD systems induced by Japanese
health care needs, Review, Computer Methods and Programs in Biomedicine, 2008;92:238-248.
ේ⪺㧔๺ᢥ㧕
1㧕 ᏒᎹൎᒄ㧘ዊኹศⴤ㧘ᄢᯅ৻਽㧘᧖ጊ㓷ਯ㧘ች࿾೑᣿㧘⮮↰ᐢᔒ㧚╬⸃௝ᐲ↹௝ࠍ↪޿ߚ CT ߩᕈ⢻⹏ଔ㧘ᣣᧄ᡼኿✢ᛛⴚቇળ㔀⹹ 2006 ᐕ㧧62 Ꮞ㧦522㧙528㧚
2㧕 ਛᎹବ᣿㧘ᨋ ૫ౖ㧘⇌ਛ⵨ม㧘㕍ጊ 㓁㧘᳓⨲ ⼾㧘⮮↰᣿ብ㧘ടฎᎹᱜൎ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ጊᧄື਽㧚1 ᨎߩ 2 ᰴర⌒ᐩ↹௝ࠍ↪޿ߚ 3 ᰴర⌒ᐩ↹௝ߩ᭴▽㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2006 ᐕ㧧23 Ꮞ㧦
85㧙90㧚
3㧕 㜞ᯅ ੫㧘⇌ਛ⵨ม㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧘㕍ጊ 㓁㧘᳓⨲ ⼾㧘⮮↰᣿ብ㧘ടฎᎹᱜൎ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧚⌒ᐩ↹௝ߦ߅ߌࠆ㜞ⴊ࿶∝⸻ᢿᡰេߩߚ߼ߩⴊ▤੤෷ㇱߩ⥄േ⸃ᨆ㧘Medical Imaging Technology
2006 ᐕ㧧24 Ꮞ㧦270㧙276㧚
4㧕 ਛᎹବ᣿㧘ᨋ ૫ౖ㧘⇌ਛ⵨ม㧘㕍ጊ 㓁㧘᳓⨲ ⼾㧘⮮↰᣿ብ㧘ടฎᎹᱜൎ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ጊᧄື਽㧚⌒ᐩ↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩߚ߼ߩⴊ▤ᶖ෰↹௝ࠍ↪޿ߚⷞ␹⚻੃㗡ߩ⥄േ⹺⼂෸߮ᡆૃ┙૕ⷞ↹௝↢ᚑ߳ߩᔕ↪㧘㔚ሶᖱႎㅢାቇળ⺰ᢥ⹹ D 2006 ᐕ㧧J89-D Ꮞ㧦2491㧙2501㧚
5㧕 ኹᧄ◊ม㧘᧛⿧⾆ⴕ㧘ᵤဈ᣽೑㧘⮮↰ᐢᔒ㧚ߪࠎߛࡃࡦࡊߦ⊒↢ߒߚᓸዊࡏࠗ࠼ߩ⥄േᬌ಴㧘㔚᳇ቇળ⺰ᢥ⹹ D 2006 ᐕ㧧126 Ꮞ㧦1514㧙1521㧚
6㧕 ᧻የ ᖗ㧘᧡ਅᷕᰴ㧘⮮↰ᐢᔒ㧘 ᷨືᦶ㧘᧖ጊᷕሶ㧚࠺ࠖࠫ࠲࡞૏⋧ࠦࡦ࠻࡜ࠬ࠻ࠗࡔ࡯ࠫࡦࠣߦ߅ߌ
ࠆࠛ࠶ࠫᒝ⺞ߩ⹏ଔ㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2006 ᐕ㧧23 Ꮞ㧦120㧙123㧚
7㧕 Ꮉዥ வ㧘๟ ะᩕ㧘ᒛ ቇァ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘ㄭ⮮ᶈผ㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚න
⚐ X ✢ CT ↹௝ߦ߅ߌࠆ⢄⤳ⴊ▤ߩ⥄േ᛽಴ᴺߩೋᦼᬌ⸛㧘 ක↪↹௝ᖱႎቇળ㔀⹹ 2006 ᐕ㧧23 Ꮞ㧦141
㧙144㧚
8㧕 ጊౝ዁ผ㧘ౝጊ⦟৻㧘ዊ᫾ Ả㧘ᮮጊ㦖ੑ㇢㧘ේ ᱞผ㧘቟⮮ᒄ㆏㧘ጊᎹᒄ଻㧘ጤ㑆 ੧㧘ᤊ ඳᤘ㧘⮮↰ᐢᔒ㧚MRA ↹௝ߦ߅ߌࠆ⣖ⴊ▤ฬߩ⥄േኻᔕઃߌᚻᴺߩ㐿⊒㧘↢૕කᎿቇ 2007 ᐕ㧧45 Ꮞ㧦27㧙35㧚
9㧕 ૒⮮⌀⍮ሶ㧘›੗ᱜ↵㧘๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧚ࡕ࠺࡞ࡑ࠶࠴ࡦࠣߦࠃࠆࡑ࡞࠴ࠬ࡜ࠗࠬ CT ↹௝߆ࠄߩ❑ㇳౝ⢖േ⣂ߩ᛽಴㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2007 ᐕ㧧24 Ꮞ㧦13㧙18㧚
10㧕 ౝጊ⦟৻㧘᧻੗ ◊㧘ᮮጊ㦖ੑ㇢㧘๟ ะᩕ㧘ේ ᱞผ㧘቟⮮ᒄ㆏㧘ᵻ㊁㓉ᒾ㧘ട⮮ඳၮ㧘ጤ㑆 ੧㧘ᤊඳᤘ㧘⮮↰ᐢᔒ㧚⣖ MR ↹௝ߦ߅ߌࠆ࡜ࠢ࠽᪪Ⴇߩᬌ಴ᴺ㧘㔚ሶᖱႎㅢାቇળ⺰ᢥ⹹ D 2007 ᐕ㧧J90-D
Ꮞ㧦1820㧙1829㧚
11㧕 ዊ᫾ Ả㧘ౝጊ⦟৻㧘ጊౝ዁ผ㧘ᮮጊ㦖ੑ㇢㧘ේ ᱞผ㧘ጊᎹᒄ଻㧘቟⮮ᒄ㆏㧘ጤ㑆 ੧㧘ᤊ ඳᤘ㧘⮮↰ᐢᔒ㧚ࡌࠢ࠻࡞㓸ਛᐲࡈࠖ࡞࠲ࠍ↪޿ߚ MRA ↹௝ߦ߅ߌࠆ⣖േ⣂≜ߩᬌ಴ᴺ㧘ක↪↹௝ᖱႎቇળ㔀⹹
2007 ᐕ㧧24 Ꮞ㧦84㧙89㧚
12㧕 ർᎹノᒾ㧘๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘ㄭ⮮ᶈผ㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚⢄⤳㔚ሶࠕ࠻࡜ࠬߣ✢ᒝ⺞ࡈࠖ࡞࠲ߦࠃࠆ૕ᐙㇱ㕖ㅧᓇ X ✢ CT ௝߆ࠄߩਛ⢄㕒⣂ߩ⥄േ᛽಴㧘ᣣᧄ᡼኿✢ᛛⴚቇળ㔀⹹ 2007 ᐕ㧧63 Ꮞ㧦1382㧙1387㧚
13㧕 ᨋ ㆐㇢㧘๟ ะᩕ㧘㒸 ⪇ጪ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘᩿↢ᜏม㧘ᤊ ඳᤘ㧚X ✢ CT ௝ߦ߅ߌࠆ⣄ᬁᬁ૕ㇱߩ㛽ኒᐲߩ⺞ᩏ㧘ක↪↢૕Ꮏቇ 2007 ᐕ㧧45 Ꮞ㧦256㧙266㧚
14㧕 ࿡ᨑ℉਽㧘ౝጊ⦟৻㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ട⮮ඳၮ㧘ᵻ㊁㓉ᒾ㧘ᤊ ඳᤘ㧘ጊᎹᒄ଻㧘቟⮮ᒄ㆏㧘ጤ㑆੧㧚ࠢ࡜ࠬ࠲࡝ࡦࠣࠍ↪޿ߚ⣖࠼࠶ࠢ MR ↹௝ߦ߅ߌࠆή∝୥ᕈᄢ⣖⊕⾰∛ᄌߩᬌ಴ᴺ㧘Medical Imaging

㧙㧙Technology 2008 ᐕ㧧26 Ꮞ㧦39㧙47㧚
15㧕 ᨋ ㆐㇢㧘๟ ะᩕ㧘㒸 ⪇ጪ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚X ✢ CT ௝ߦ߅ߌࠆ᳇▤࡮᳇▤ᡰߩᒻ⁁ᖱႎߩ⸘᷹㧘ක↪↹௝ᖱႎቇળ㔀⹹ 2008 ᐕ㧧25 Ꮞ㧦18㧙21㧚
16㧕 ർᎹノᒾ㧘๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘ㄭ⮮ᶈผ㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚૕ᐙㇱ㕖ㅧᓇ
X ✢ CT ↹௝ߦ߅ߌࠆ⢄⤳ࠕ࠻࡜ࠬߩ⥄േ↢ᚑᴺߩឭ᩺ߣߘߩ⢄⤳⥄േ᛽಴ᴺ߳ߩᔕ↪㧘㔚ሶᖱႎㅢାቇ
ળ⺰ᢥ⹹ D 2008 ᐕ㧧J91-D Ꮞ㧦1837㧙1850㧚
17㧕 ␹⼱⋥Ꮧ㧘๟ ะᩕ㧘㒸 ⪇ጪ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚㛽ᩰߣ㛽ᩰ╭ߩ⸃೬ቇ⊛૏⟎㑐ଥߦၮߠߊ૕ᐙㇱ X ✢ CT ↹௝߆ࠄߩ㛽ᩰ╭ߩ⥄േ᛽಴㧘㔚ሶᖱႎㅢାቇળ⺰ᢥ⹹ D
2008 ᐕ㧧J91-D Ꮞ㧦1918㧙1922㧚
18㧕 ᳰᚭ␭ม㧘⑔ጟᄢテ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘㜞↰ᖝ㓶㧘㆙⮮⊓༑ሶ㧘᫪↰ቁሶ㧚ో੃ᚱ⿥㖸ᵄ↹௝ߦ߅ߌࠆ⣲≜௝⥄േᬌ಴ࠪࠬ࠹ࡓߩߚ߼ߩᏀฝ੃ᚱ↹௝ߩᲧセߦࠃࠆன㓁ᕈ೥㒰ᴺ㧘㔚ሶᖱႎㅢାቇળ⺰ᢥ⹹ D
2008 ᐕ㧧J91-D Ꮞ㧦1923㧙1926㧚
19㧕 ጊౝ዁ผ㧘ౝጊ⦟৻㧘ዊ᫾ Ả㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧘቟⮮ᒄ㆏㧘ጊᎹᒄ଻㧘ጤ㑆 ੧㧚⣖ MRA ↹௝ߦ߅ߌࠆ⋧ኻ⊛ⴊ▤㐳ߦၮߠ޿ߚ㐽Ⴇߩ⥄േᬌ಴ᴺ㧘Medical Imaging Technology 2008 ᐕ㧧26 Ꮞ㧦251
㧙260㧚
20㧕 ᄹ⦟᧛੖චᔒ㧘ᨋ ㆐㇢㧘๟ ะᩕ㧘ේ ᱞผ㧘㒸 ⪇ጪ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚૕ᐙㇱ X ✢ CT ↹௝ߦ߅ߌࠆ૕⣧᭴ㅧߩ⥄േ⹺⼂㧘Medical Imaging Technology 2008 ᐕ㧧26 Ꮞ㧦261
㧙271㧚
21㧕 ᨋ ㆐㇢㧘๟ ะᩕ㧘㒸 ⪇ጪ, ේ ᱞผ㧘⮮↰ᐢᔒ㧘ᮮጊ㦖ੑ㇢㧘౗᧻㓷ਯ㧘ᤊ ඳᤘ㧚X ✢ CT ↹௝߆ࠄߩੱ૕ߩᬁ૕ᶏ✎㛽ㇱߦ߅ߌࠆૐ㛽ኒᐲ㗔ၞߩಽᏓߦ㑐ߔࠆ⎇ⓥ㧘↢૕කᎿቇ 2008 ᐕ㧧46 Ꮞ㧦451
㧙457㧚
22㧕 ⑔↰࿻૓㧘ਛᎹବ᣿㧘⇌ਛ⵨ม㧘ᨋ ૫ౖ㧘ේ ᱞผ㧘⮮↰ᐢᔒ㧚↢૕⹺⸽ߩߚ߼ߩ⌒ᐩ↹௝ߦ߅ߌࠆⴊ
▤௝ࠍ↪޿ߚ㘃ૃᐲ▚಴ᴺ㧘↹௝㔚ሶቇળ⹹ 2008 ᐕ㧧37 Ꮞ㧦1020㧙1028㧚ේ⪺㧔᰷ᢥ㧕
1㧕 Nakagawa T, Hara T, Fujita H, Iwase T, Endo T. A novel automated contour extraction method of
mammographic mass shadow using an improved active contour model. Proc. 7th International
Workshop on Digital Mammography. 2006:618-622.
2㧕 Matsubara T, Ichikawa T, Hara T, Fujita H, Kasai S, Endo T, Iwase T. Automated detection methods
for architectural distortions based on concentration of mammary gland on mammograms. Proc. 7thInternational Workshop on Digital Mammography. 2006:646-650.
3㧕 Sano K㧘Kawasaki M㧘Ishihara Y㧘Okubo M㧘Tsuchiya K㧘Nishigaki K㧘Zhou X㧘Minatoguchi S㧘
Fujita H㧘Fujiwara H. Assessment of vulnerable plaques causing acute coronary syndrome using
integrated backscatter intravascular ultrasound. J Amer Coll Cardiol. 2006;47:734-741.
IF 11.054
4㧕 Lee GN, Hara T, Fujita H. Classifying masses as benign or malignant based on co-occurrence matrix
textures: A comparison study of different gray level quantizations. Digital Mammography, 8thInternational Workshop IWDM2006 Proceedings. Eds. S.M.Astley, M.Brady, C.Rose, and R.Zwiggelaar,
Lecture Notes in Computer Science. 2006;4046:332-339.
5㧕 Hara T, Makita T, Matsubara T, Fujita H, Inenaga Y, Endo T, Iwase T. Automated detection method forarchitectural distortion with spiculation based on distribution assessment of mammary gland on
mammogram. Digital Mammography, 8th International Workshop IWDM2006 Proceedings. Eds.
S.M.Astley, M.Brady, C.Rose, and R.Zwiggelaar, Lecture Notes in Computer Science.
2006;4046:370-3375.
6㧕 Fukuoka D, Ikedo Y, Hara T, Fujita H, Takeda E, Endo T, Morita T. Development of breast ultrasound
CAD system for screening. Digital Mammography. 8th International Workshop IWDM2006
Proceedings, Eds. S.M.Astley, M.Brady, C.Rose, and R.Zwiggelaar, Lecture Notes in Computer Science.
2006;4046:392-398.
7㧕 Sugisaki K, Fujita H, Goto H, Hoshi H. Complementary role of computer aided detection in
mammography. Digital Mammography, 8th International Workshop IWDM2006 Proceedings. Eds.
S.M.Astley, M.Brady, C. Rose, and R. Zwiggelaar, Lecture Notes in Computer Science.
2006;4046:504-508.
8㧕 Zhou X, Hayashi T, Hara T, Fujita H, Yokoyama R, Kiryu T, Hoshi H. Automatic segmentation andrecognition of anatomical lung structures from high-resolution chest CT images. Computerized
Medical Imaging and Graphics. 2006;30:299-313.
IF 0.848
9㧕 Uchiyama Y, Yamauchi M, Ando H, Yokoyama R, Hara T, Fujita H, Iwama T, Hoshi H. Automatedclassification of cerebral arteries in MRA images and its application to maximum intensity projection.
Proc. of the 28th IEEE EMBS Annual International Conferencs. 2006:4865-4868.
10㧕 Zhou X, Kitagawa T, Hara T, Fujita H, Zhang X, Yokoyama R, Kondo H, Kanematsu M, Hoshi H.
Constructing a probabilistic model for automated liver region segmentation using non-contrast X-ray
torso CT images. Proc. of 9th International Conference for Medical Image Computing andComputer-Assisted Intervention - MICCAI 2006, Part II. 2006:4191:856-863.
11㧕 Ichikawa K, Kodera Y, Fujita H. MTF measurement method for medical displays by using abar-pattern image. Journal of the Society for Information Display. 2006;14:831-837.

㧙㧙12㧕 Teramoto A, Murakoshi T, Tsuzaka M, Fujita H. Automated X-ray inspection method for fillet-lessmounted chip components. IEEJ Transactions of Electrical & Electronic Engineering (TEEE), letter.
2007;2:195-197.
13㧕 Yokoyama R, Zhang X, Uchiyama Y, Fujita H, Hara T, Zhou X, Kanematsu M, Asano T, Kondo H,
Goshima S, Hoshi H, Iwama T. Development of an automated method for the detection of lacunar
infarct regions in brain MR images. IEICE Trans. Inf. & Syst. 2007;E90-D:943-954.
14㧕 Kato H, Kanematsu M, Zhang X, Saio M, Kondo H, Goshima S, Fujita H. Computer-aided diagnosis ofhepatic fibrosis: Preliminary evaluation of MRI texture analysis using the finite difference method andan artificial neural network. AJR. 2007;189:117-122.
15㧕 Dalal P, Munsell BC, Wang S, Tang J, Oliver K, Ninomiya H, Zhou X, Fujita H. A fast 3D
correspondence method for statistical shape modeling. Proc. of IEEE Conference on Computer Vision
and Pattern Recognition (CVPR). 2007;1-8.
16㧕 Teramoto A, Murakoshi T, Tsuzaka M, Fujita H. Development of high speed oblique X-ray CT systemfor printed circuit board. SICE Trans. on Industrial Application. 2007;6:72-77.
17㧕 Uchiyama Y, Yokoyama R, Ando H, Asano T, Kato H, Yamakawa H, Yamakawa H, Hara T, Iwama T,
Hoshi H, Fujita H. Improvement of automated detection method of lacunar infarcts in brain MR
images. Proc. of 29th IEEE Engineering in Medicine and Biology Conference Management System(EMBS) Annual International Conference. 2007;1599-1602.
18㧕 Nakagawa T, Hayashi Y, Hatanaka Y, Aoyama A, Hara T, Fujita A, Kakogawa M, Fujita H,
Yamamoto T. Three-dimensional reconstruction of optic nerve head from stereo fundus images and its
quantitative estimation. Proc. of 29th IEEE Engineering in Medicine and Biology ConferenceManagement System (EMBS) Annual International Conference. 2007;6747-6750.
19㧕 Teramoto A, Murakoshi T, Tsuzaka M, Fujita H. Automated solder inspection method by means of
X-ray oblique computed tomography. Proc. of IEEE International Conference on Image Processing.
2007;V-433-V-436.
20㧕 Teramoto A, Murakoshi T, Tsuzaka M, Fujita H. Automated solder inspection technique for
BGA-mounted substrates by means of oblique computed tomography. IEEE Trans. Electronics
Packaging Manufacturing. 2007;30:285-292.
21㧕 Ikedo Y, Fukuoka D, Hara T, Fujita H, Takada E, Endo T, Morita T. Development of a fully automatic
scheme for detection of masses in whole breast ultrasound images. Medical Physics. 2007;34:4378-4388.
22㧕 Teramoto A, Yamada M, Murakoshi T, Tsuzaka M, Fujita H. High speed oblique CT system for solder
bump inspection. Proc. of the 33rd Annual Conference of the IEEE Industrial Electronics Society(IECON). 2007;2689-2693.
23㧕 Nagata C, Matsubara T, Hara T, Fujita H, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H.
Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Cancer Epidemiolgy,
Biomarkers & Prevention. 2007;16:2509-2512.
24㧕 Uchiyama Y, Yokoyama R, Ando H, Asano T, Kato H, Yamakawa H, Yamakawa H, Hara T, Iwama T,
Hoshi H, Fujita H. Computer-aided diagnosis scheme for detection of lacunar infarcts in MR images.
Academic Radiology. 2007;14:1554-1561.
25㧕 Lee GN and Fujita H. K-means clustering for classifying unlabelled MRI data, Proc. of Digital Image
Computing Techniques and Applications (DICTA 2007). IEEE Computer Society. 2007;92-98.
26㧕 Zhou X, Ninomiya H, Hara T, Fujita H, Yokoyama R, Cheng H, Kiryu T, Hoshi H. Automatedestimation of the upper surface of the diaphragm in 3-D CT images. IEEE Transactions on Biomedical
Engineering. 2008;55:351-353.
27㧕 Zhang X, Fujita H, Qin T, Zhao J, Qin Y, Gao C, Long L, Zhang Z. A novel method for extraction of
spleen by using thin-plate splines (TPS) deformation and edge detection from abdominal CT images.
2008 International Conference on BioMedical Engineering and Informatics. 2008:830-834.
28㧕 Matsuo S, Fujita H, Morishita J, Katafuchi T, Honda C, Sugisaki J. Evaluation of a phase contrast
imaging with digital mammography, Digital Mammography, E.A.Krupinski (Ed.), Springer Lectures
Notes in Computer Science (LNCS) series; LNCS5116. 2008:130-136.
29㧕 Ikedo Y, Morita T, Fukuoka D, Hara T, Fujita H, Takada E, Endo T. Computerized classification ofwhole breast ultrasound images based on mammary gland patterns, Digital Mammography,
E.A.Krupinski (Ed.), Springer Lectures Notes in Computer Science (LNCS) series; LNCS5116.
2008:188-195.
30㧕 Lee GN, Fukuoka D, Ikedo Y, Hara T, Fujita H, Takada E, Endo T, Morita T. Classification of benign
and malignant masses in ultrasound breast image based on geometric and echo features, 9thInternational Workshop on Digital Mammography, Digital Mammography, E.A.Krupinski (Ed.),
Springer Lectures Notes in Computer Science (LNCS) series; LNCS5116. 2008:433-439.
31㧕 Hara T, Fukuoka D, Ikedo Y, Takada E, Fujita H, Endo T, Morita T. Development of whole breast
ultrasound viewer and automated mass detection system, Digital Mammography, E.A.Krupinski (Ed.),
Springer Lectures Notes in Computer Science (LNCS) series; LNCS5116. 2008:455-462.
32㧕 Nakagawa T㧘Hara T㧘Fujita H㧘Horita K㧘Iwase T, Endo T. Radial-searching contour extraction
method based on a modified active contour model for mammographic masses, Radiological Physics and㧙㧙

IF 0.245

IF 2.470

IF 0.903
IF 3.198

IF 4.642

IF 2.094

IF 1.622

Technology. 2008;1:151-161.
33㧕 Kawajiri S, Zhou X, Zhang X, Hara T, Fujita H, Yokoyama R, Kondo H, Kanematsu M, Hoshi H.
Automated segmentation of hepatic vessels in non-contrast X-ray CT images, Radiological Physics andTechnology. 2008;1:214-222.
34㧕 Uchiyama Y, Kunieda T, Asano T, Kato H, Hara T, Kanematsu M, Iwama T, Hoshi H, Kinosada Y,
Fujita H. Computer-aided diagnosis scheme for classification of lacunar infarcts and enlarged
Virchow-Robin spaces in brain MR image, Proc of 30th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society. 2008:3908-3911.
35㧕 Hatanaka Y, Nakagawa T, Hayashi Y, Hara T, Fujita H. Improvement of automated detection methodof hemorrhages in fundus images, Proc of 30th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society. 2008:5429-5432.
36㧕 Zhou X, Han M, Hara T, Fujita H, Sugisaki K, Chen H, Lee G, Yokoyama R, Kanematsu M, Hoshi H.
Automated segmentation of mammary gland regions in non-contrast X-ray CT images. Computerized
Medical Imaging and Graphics. 2008;32:699-709.
IF 0.848
37㧕 Nakagawa T, Suzuki T, Hayashi Y, Mizukusa Y, Hatanaka Y, Ishida K, Hara T, Fujita H, Yamamoto T.
Quantitative depth analysis of opticnerve head using stereo retinal fundus image pair. Journal of
Biomedical Optics. 2008;13:1-10.
IF 3.0844㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦⮮↰ᑝᔒ㧘⎇ⓥಽᜂ⠪㧦ᤊ ඳᤘ㧘ᓟ⮮⵨ᄦ㧘౗᧻㓷ਯ㧘᩿↢ᜏม㧘ේ ᱞผ㧘๟ ะᩕ㧘૒੗◊௾㧘᧻ේ෹ሶ㧘᧘ ㎬▸㧘⇌ਛ⵨ม㧘⑔ጟᄢテ㧘㆙⮮⊓༑ሶ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄․ቯ㗔ၞ⎇ⓥ㧔ᄙᰴరක↪↹௝ߩ⍮⊛⸻ᢿᡰេ㧕㧦ᱜᏱ᭴ㅧߩℂ⸃ߦၮߠߊ⍮⊛ CAD㧧ᐔᚑ 15
㧙18 ᐕᐲ㧧56,000 ජ౞(14,000㧦14,000㧦14,000㧦14,000 ජ౞)
2㧕 ⎇ⓥઍ⴫⠪㧦⮮↰ᑝᔒ㧘⎇ⓥಽᜂ⠪㧦G.N.Lee㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧔․೎⎇ⓥຬᅑബ⾌㧕㧦ක↪↹௝ߦ߅ߌࠆࠦࡦࡇࡘ࡯࠲ᡰេ߇ࠎ⥄േᬌ಴ࠪࠬ࠹ࡓߩ㐿⊒ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 17㧙18 ᐕᐲ㧧
2,400 ජ౞(1,200㧦1,200 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦✽㊁ ❥㧘⎇ⓥಽᜂ⠪㧦㐳⼱Ꮉ⚐৻㧘ᷡ᳓ᤘિ㧘ᧃ᳗ᐽੳ㧘⮮↰ᑝᔒ㧘ฬข ඳ㧘๺↰⌀৻㧘ੳᧁ ⊓㧘ౝጊ⩿ᥓሶ㧧ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄㧦ᯏ᪾㐿⊒⎇ⓥ‫↹࡞࠲ࠫ࠺ޟ‬௝ࠍ೑↪
ߒߚ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ‫ޠ‬㧧ᐔᚑ 17㧙18 ᐕᐲ㧧2,400 ජ౞(1,200㧦1,200 ජ౞)㧔ಽᜂಽ㧕4㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧘⎇ⓥಽᜂ⠪㧦 ᷨືᦶ㧘⮮↰ᑝᔒ㧧⁛┙ⴕ᡽ᴺੱᣣᧄቇⴚᝄ⥝ળ⑼ቇ⎇ⓥ
⾌⵬ഥ㊄ၮ⋚⎇ⓥ࡮ડ↹㧦PET-CT ↹௝ߦ߅ߌࠆⶄᢙ PET ᩭ⒳ߩ㓸ⓍಽᏓ࠺࡯࠲ࡌ࡯ࠬൻߦ㑐ߔࠆ⺞ᩏ㧧ᐔᚑ 18 ᐕᐲ㧧1,800 ජ౞5㧕 ⎇ⓥઍ⴫⠪㧦๟ ะᩕ㧧⁛┙ⴕ᡽ᴺੱᣣᧄቇⴚᝄ⥝ળ⑼ቇ⎇ⓥ⾌⵬ഥ㊄⧯ᚻ⎇ⓥ(B)㧦3 ᰴర૕ᐙㇱCT ↹௝߆ࠄߩੱ૕⚵❱࡮⤳ེ㗔ၞߩ⥄േ⹺⼂ߦ㑐ߔࠆၮ␆⊛⎇ⓥ㧧ᐔᚑ 17㧙19 ᐕᐲ㧧1,900 ජ౞(700㧦700㧦500 ජ౞)
6㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧧ᄢ๺⸽೛ࡋ࡞ࠬ⽷࿅㧦ਛ࡮㜞ᐕ⠪ߩ଻㒾࡮ක≮߅ࠃ߮⑔␩╬ߦ㑐ߔࠆ⎇ⓥ⺞ᩏ㧦⿥⸃௝ᛛⴚࠍ↪޿ߚࡐࠫ࠻ࡠࡦᢿጀ᠟௝㧔PET㧕ⵝ⟎ߩ㜞⸃௝ᐲൻ㧧ᐔᚑ 18㧙19 ᐕᐲ㧧1,000ජ౞7㧕 ⎇ⓥઍ⴫⠪㧦㐳⼱Ꮉ⚐৻㧘⎇ⓥಽᜂ⠪㧦ੳᧁ ⊓㧘⮮↰ᑝᔒ㧘ᷡ᳓ᤘિ㧘᫪ ஜ╷㧘✽㊁ ❥㧘᫪㓷᮸㧘◉ፒ⾫ᴦ㧘᧛᧻ᐘ↵㧘᧻ㄼᱜ᮸㧘ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄㧦ᯏ᪾㐿⊒⎇ⓥ‫↹࡞࠲ࠫ࠺ޟ‬௝
ಣℂߦࠃࠆ߇ࠎ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ‫ޠ‬㧧ᐔᚑ 19㧙20 ᐕᐲ㧧2,900 ජ౞(1,400㧦1,500 ජ౞)㧔ಽᜂ㈩ಽ㗵㧕8㧕 ⎇ⓥઍ⴫⠪㧦⍹ᯅᔘม㧘⎇ⓥಽᜂ⠪㧦⍹↰ቁት㧘ᬀ᧻ቁᖝ㧘ጊ↰㓉ਯ㧘ౝጊ⩿ᥓሶ㧘ේ ᱞผ㧘ෘ‫ࠎ߇੃ࠆࠃߦࠖࡈ࡜ࠣࡕࡦࡑ࡞࠲ࠫ࠺ޟ‬ᬌ⸻ߩല₸෸߮♖ᐲะ਄࡮⹏ଔߦ
↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄㧦㑐ߔࠆ⎇ⓥ‫ޠ‬㧧ᐔᚑ 19㧙20 ᐕᐲ㧧2,400 ජ౞(1,200㧦1,200 ජ౞)㧔ಽᜂ㈩ಽ㗵㧕9㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧘⎇ⓥಽᜂ⠪㧦 ᷨືᦶ㧘⮮↰ᑝᔒ㧘⁛┙ⴕ᡽ᴺੱᣣᧄቇⴚᝄ⥝ળ⑼ቇ⎇ⓥ
⾌⵬ഥ㊄㧦‫ⶄޟ‬ᢙ PET ᩭ⒳ߩ㓸ⓍಽᏓߩቯ㊂ൻߦࠃࠆੱ૕ઍ⻢ࠕ࠻࡜ࠬߩ᭴▽ߦ㑐ߔࠆ⎇ⓥ‫ޠ‬㧧ᐔᚑ19㧙22 ᐕᐲ(900 ජ౞㧦1,100 ජ౞㧦800 ජ౞㧦700 ජ౞)
10㧕 ⎇ⓥઍ⴫⠪㧦᳗↰⍮㉿㧘⎇ⓥಽᜂ⠪㧦ᷡ᳓ᒄਯ㧘⮮↰ᑝᔒ㧘ᱞ↰ೣਯ㧧⁛┙ⴕ᡽ᴺੱᣣᧄቇⴚᝄ⥝ળ⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(B)㧦੃߇ࠎ࡝ࠬࠢߣߒߡߩࠛࠬ࠻ࡠࠥࡦ㧘ࡔ࡜࠻࠾ࡦߣࠨ࡯ࠞ࠺ࠖࠕ
ࡦ࡝࠭ࡓߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 19㧙21 ᐕᐲ㧧14,800 ජ౞(5,200㧦4,800㧦4,800 ජ౞)
11㧕 ⎇ⓥઍ⴫⠪㧦⮮↰ᑝᔒ㧧ᐔᚑ 19 ᐕᐲࠦ࠾ࠞࡒࡁ࡞࠲↹௝⑼ቇᝄ⥝⽷࿅⎇ⓥഥᚑ㊄㧧ᐔᚑ 19 ᐕ㧧300ජ౞
12㧕 ⎇ⓥઍ⴫⠪㧦๟ ะᩕ㧧ጘ㒂ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼⎇ⓥᵴᕈൻ㧔ක㧕ߩߚ߼ߩ⎇ⓥ⾌⵬ഥ㊄㧧ᐔ㧙㧙ᚑ 19 ᐕ㧧100 ජ౞
13㧕 ⎇ⓥઍ⴫⠪㧦๟ ะᩕ㧧ᨰ᫪ᖱႎ⑼ቇᝄ⥝⽷࿅‫ޟ‬ᐔᚑ 19 ᐕᐲ⎇ⓥഥᚑ㊄‫ޠ‬㧧ᐔᚑ 19 ᐕ㧧900 ජ౞
14㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧧ᐔᚑ 20 ᐕᐲ┙⍹⑼ቇᛛⴚᝄ⥝⽷࿅⎇ⓥഥᚑ㊄㧧ᐔᚑ 20 ᐕ㧧2,500 ජ౞
15㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧧ᐔᚑ 20 ᐕᐲ㔚᳇ㅢା᥉෸⽷࿅ᶏᄖᷰ⥶ᣏ⾌េഥ㊄㧧ᐔᚑ 20 ᐕ㧧230 ජ౞
16㧕 ⎇ⓥઍ⴫⠪㧦๟ ะᩕ㧧⽷࿅ᴺੱฬฎደ↥ᬺ⑼ቇ⎇ⓥᚲ‫ޟ‬ᐔᚑ 20 ᐕᐲ⎇ⓥ╬ഥᚑ㧔ᶏᄖᷰ⥶េഥ㧕‫ޠ‬㧧
ᐔᚑ 20 ᐕ㧧300 ජ౞
17㧕 ⎇ⓥઍ⴫⠪㧦ේ ᱞผ㧧੗਄⑼ቇᝄ⥝⽷࿅‫ޟ‬࿖㓙⎇ⓥ㓸ળ߳ߩ಴Ꮸᣏ⾌ߩ৻ㇱេഥ㊄‫ޠ‬㧧ᐔᚑ 20 ᐕ㧧
250 ජ౞
18㧕 ⎇ⓥઍ⴫⠪㧦๟ ะᩕ㧧ᐔᚑ 20 ᐕᐲጘ㒂ᄢቇ⎇ⓥᵴᕈൻ⚻⾌㧔⎇ⓥ㧦⑼⎇ណᛯᡰេ㧕㧧ᐔᚑ 20 ᐕ㧧
1,020 ජ౞2㧕ฃ⸤⎇ⓥ1㧕 ⮮↰ᑝᔒ㧦ක≮⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪㧧ᐔᚑ 18 ᐕᐲ㧧59,729
ජ౞㧦⽷࿅ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔ᢥ⑼⋭࿾ၞ⑼ቇᛛⴚᝄ⥝੐ᬺ⾌⵬ഥ㊄㧔⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ
੐ᬺ㧦ጘ㒂࡮ᄢ၂࿾ၞ‫ࠢ࠶ࠖ࠹ࡏࡠޟ‬వ┵ක≮ࠢ࡜ࠬ࠲࡯‫ޠ‬㧕ߦࠃࠆᆔ⸤㧕2㧕 ⮮↰ᑝᔒ㧦ක≮⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪ࠬ࠹࡟ࠝ⌒ᐩ↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪㧧ᐔᚑ 18 ᐕᐲ㧧5,384 ජ౞㧦⽷࿅ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔ᢥ⑼⋭࿾ၞ⑼ቇᛛⴚᝄ⥝੐ᬺ⾌⵬ഥ㊄㧔⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ੐ᬺ㧦ጘ㒂࡮ᄢ၂࿾ၞ‫ࠢ࠶ࠖ࠹ࡏࡠޟ‬వ┵ක≮ࠢ࡜ࠬ࠲࡯‫ޠ‬㧕ߦࠃࠆᆔ⸤㧕3㧕 ⮮↰ᑝᔒ㧦⌒ᐩ┙૕↹௝ࠍ↪޿ߚ⌒⑼ஜᐽ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㧧ᐔᚑ 18 ᐕᐲ㧧834 ජ౞㧦⽷࿅
ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔⚻ᷣ↥ᬺ⋭࿾ၞᣂ↢ࠦࡦ࠰࡯ࠪࠕࡓ⎇ⓥ㐿⊒੐ᬺߦࠃࠆᆔ⸤㧕
4㧕 ⮮↰ᑝᔒ㧦↹௝⸻ᢿᡰេᛛⴚߩ⎇ⓥ㐿⊒㧧ᐔᚑ 18 ᐕᐲ㧧200 ජ౞㧦ࠦ࠾ࠞࡒࡁ࡞࠲ࠛࡓࠫ࡯㧔ᩣ㧕
5㧕 ⮮↰ᑝᔒ㧦ක≮⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪㧧ᐔᚑ 19 ᐕᐲ㧧66,500
ජ౞㧦⽷࿅ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔ᢥ⑼⋭࿾ၞ⑼ቇᛛⴚᝄ⥝੐ᬺ⾌⵬ഥ㊄㧔⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ
੐ᬺ㧦ጘ㒂࡮ᄢ၂࿾ၞ‫ࠢ࠶ࠖ࠹ࡏࡠޟ‬వ┵ක≮ࠢ࡜ࠬ࠲࡯‫ޠ‬㧕ߦࠃࠆᆔ⸤㧕
6㧕 ⮮↰ᑝᔒ㧦⌒ᐩ┙૕↹௝ࠍ↪޿ߚ⌒⑼ஜᐽ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㧧ᐔᚑ 19 ᐕᐲ㧧151 ජ౞㧦⽷࿅
ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔⚻ᷣ↥ᬺ⋭࿾ၞᣂ↢ࠦࡦ࠰࡯ࠪࠕࡓ⎇ⓥ㐿⊒੐ᬺߦࠃࠆᆔ⸤㧕7㧕 ⮮↰ᑝᔒ㧦↹௝⸻ᢿᡰេᛛⴚߩ⎇ⓥ㐿⊒㧧ᐔᚑ 19 ᐕᐲ㧧200 ජ౞㧦ࠦ࠾ࠞࡒࡁ࡞࠲ࠛࡓࠫ࡯㧔ᩣ㧕
8㧕 ⮮↰ᑝᔒ㧦ක≮⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㨪㧧ᐔᚑ 20 ᐕᐲ㧧46,779
ජ౞㧦⽷࿅ᴺੱጘ㒂⋵⎇ⓥ㐿⊒⽷࿅㧔ᢥ⑼⋭࿾ၞ⑼ቇᛛⴚᝄ⥝੐ᬺ⾌⵬ഥ㊄㧔⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ
੐ᬺ㧦ጘ㒂࡮ᄢ၂࿾ၞ‫ࠢ࠶ࠖ࠹ࡏࡠޟ‬వ┵ක≮ࠢ࡜ࠬ࠲࡯‫ޠ‬㧕ߦࠃࠆᆔ⸤㧕9㧕 ⮮↰ᑝᔒ㧦↹௝⸻ᢿᡰេᛛⴚߩ⎇ⓥ㐿⊒㧧ᐔᚑ 20 ᐕᐲ㧧300 ජ౞㧦ࠦ࠾ࠞࡒࡁ࡞࠲ࠛࡓࠫ࡯㧔ᩣ㧕
3㧕౒ห⎇ⓥߥߒ
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫ
1㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ߅ࠃ߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․
㗿 2006-33562)
2㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝ಣℂⵝ⟎߅ࠃ߮↹௝ಣℂࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-82323)
3㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧦ක↪േ↹௝ߦࠃࠆ↹௝⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-83221)
4㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ੑ᧛ ੳ㧦ක↪↹௝ಣℂⵝ⟎෸߮ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-83950)
5㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫↹߮ࠃ߅ޔ‬௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿 2006-196322)
6㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫↹߮ࠃ߅ޔ‬௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿 2006-196323)
7㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ጤ㑆 ੧㧘቟⮮ᒄ㆏㧘ੑ᧛ ੳ㧦ක↪↹௝ಣℂⵝ⟎(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(PCT/JP2006/316595㧦․㗿 2007-533204)8㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝᠟ᓇⵝ⟎෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-243484)
9㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝᠟ᓇⵝ⟎෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿㧙㧙2006-243485)
10㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ߅ࠃ߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․
㗿 2006-255243)
11㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ߅ࠃ߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(PCT/JP2006/318761)
12㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ੑ᧛ ੳ㧦ක↪↹௝ಣℂⵝ⟎‫↹ޔ‬௝ಣℂᣇᴺ෸߮ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18
ᐕᐲ(․㗿 2006-257617)
13㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ੑ᧛ ੳ㧦ක↪↹௝ಣℂⵝ⟎‫ޔ‬ක↪↹௝ಣℂᣇᴺ෸߮ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ
18 ᐕᐲ(․㗿 2006-257695)
14㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧦⿥㖸ᵄ੃ᚱ⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-257169)
15㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ߅ࠃ߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․
㗿 2006-260340)
16㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝ಣℂⵝ⟎߅ࠃ߮↹௝ಣℂࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(PCT/JP2006/318912)
17㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫↹߮ࠃ߅ޔ‬௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕ
ᐲ(PCT/JP2006/318911)
18㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫↹߮ࠃ߅ޔ‬௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕ
ᐲ(PCT/JP2006/318910)
19㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧘ᨋ ૫ౖ㧦⿥㖸ᵄ੃ᚱ⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿 2006-257170)
20㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧘ᨋ ૫ౖ㧦⿥㖸ᵄ੃ᚱ⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕ
ᐲ(PCT/JP2006/319165)
21㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧦⿥㖸ᵄ੃ᚱ⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(PCT/JP2006/319164)
22㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ੑ᧛ ੳ㧦ක↪↹௝ಣℂⵝ⟎‫↹ޔ‬௝ಣℂᣇᴺ෸߮ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18
ᐕᐲ(PCT/JP2006/319304)
23㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧘ੑ᧛ ੳ㧦⺒ᓇᡰេⵝ⟎‫⺒ޔ‬ᓇᡰេᣇᴺ෸߮ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․
㗿 2006-262257)24㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧦੃ᚱ↹௝⸻ᢿࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 18 ᐕᐲ(․㗿
2006-268087)
25㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘㋈ᧁቁ૫㧦↹௝ಣℂⵝ⟎(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․㗿 2007-41792)26㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦⌒ᐩ↹௝⹺⸽ⵝ⟎෸߮⌒ᐩ↹௝⹺⸽ࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․㗿 2007-48691)
27㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫ޔ‬෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․
㗿 2007-62899)
28㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫ޔ‬෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․
㗿 2007-86828)
29㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫ޔ‬෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․
㗿 2007-86829)
30㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦⌒ᐩᬌᩏ↹௝⸃ᨆࠪࠬ࠹ࡓ‫ޔ‬෸߮⌒ᐩᬌᩏ↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 19 ᐕᐲ(․㗿 2007-188419)
31㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧘㚍ᧁᷡ㓉㧦⿥㖸ᵄ੃ᚱ⸻ᢿᡰេࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ
20 ᐕᐲ(․㗿 2008-72795)
32㧕 ⮮↰ᑝᔒ㧘⑔ጟᄢテ㧘ේ ᱞผ㧘ട⮮ᕺม㧘㚍ᧁᷡ㓉㧦⿥㖸ᵄ⸻ᢿᡰេࠪࠬ࠹ࡓ(⊒᣿)㧧ᐔᚑ 20 ᐕᐲ(․㗿 2008-72796)
33㧕 ⮮↰ᑝᔒ㧘ౝጊ⦟৻㧦ක↪↹௝ಣℂⵝ⟎෸߮⇣Ᏹ㒶ᓇᬌ಴ᣇᴺ(⊒᣿)㧧ᐔᚑ 20 ᐕᐲ(․㗿 2008-75961)
34㧕 ⮮↰ᑝᔒ㧘ਛᎹବ᣿㧘ᨋ ૫ౖ㧦↹௝⸃ᨆࠪࠬ࠹ࡓ‫ޔ‬෸߮↹௝⸃ᨆࡊࡠࠣ࡜ࡓ(⊒᣿)㧧ᐔᚑ 20 ᐕᐲ(PCT/JP2008/054272)

㧙㧙6㧚ቇળᵴേ
1㧕ቇળᓎຬ⮮↰ᑝᔒ㧦
1㧕 ᣣᧄක↪↹௝Ꮏቇળᐙ੐(㨪⃻࿷)2㧕 ᣣᧄ੃⣼࡮↲⁁⣼⿥㖸ᵄ⸻ᢿળ⼏ᐙ੐(㨪⃻࿷)3㧕 ᣣᧄ੃≸↹௝⎇ⓥળ࠺ࠫ࠲࡞ಽ⑼ળᆔຬ(㨪⃻࿷)4㧕 ࠦࡦࡇࡘ࡯࠲ᡰេ↹௝⸻ᢿቇળ೽ળ㐳(㨪ᐔᚑ 20 ᐕ 9 ᦬)
5㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળ೽ኾ㐷ᆔຬ㐳(㨪ᐔᚑ 19 ᐕ 5 ᦬)
6㧕 ක↪↹௝ᖱႎቇળળ㐳(㨪⃻࿷)7㧕 Computer Assisted Radiology and Surgery (CARS 2006), Program Committee member(㨪ᐔᚑ 18
ᐕ 6 ᦬)
8㧕 ᣣᧄක↪↹௝Ꮏቇળ JAMIT ᄢળ 2006 ࡊࡠࠣ࡜ࡓᆔຬ(ᐔᚑ 18 ᐕ 1 ᦬㨪ᐔᚑ 18 ᐕ 7 ᦬)
9㧕 6th Symposium of the Scandinavian Japan Radiological Society and 9th Nordic Japan PACS
Symposium, Scientific Advisory Board member (ᐔᚑ 18 ᐕ 1 ᦬㨪ᐔᚑ 18 ᐕ 9 ᦬)
10㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ⹏⼏ຬ(ᐔᚑ 18 ᐕ 4 ᦬㨪ᐔᚑ 20 ᐕ 4 ᦬)
11㧕 ᣣᧄࠬࠞࡦࠫ࠽ࡆࠕ᡼኿✢කቇදળᐙ੐(ᐔᚑ 18 ᐕ 4 ᦬㨪⃻࿷)12㧕 ᣣᧄ੃≸ᬌ⸻ቇળ ╙ 16 ࿁✚ળࡊࡠࠣ࡜ࡓᆔຬ(ᐔᚑ 18 ᐕ 4 ᦬㨪ᐔᚑ 18 ᐕ 11 ᦬)
13㧕 International Workshop on Digital Mammography 2008, Scientific Committee member(ᐔᚑ 18
ᐕ 7 ᦬㨪ᐔᚑ 20 ᐕ 7 ᦬)
14㧕 Medical Imaging and Informatics (MIMI 2007), International Program Committee member(ᐔᚑ18 ᐕ 10 ᦬㨪ᐔᚑ 19 ᐕ 8 ᦬)
15㧕 Computer Assisted Radiology and Surgery (CARS 2007), Program Committee member(ᐔᚑ 18
ᐕ 12 ᦬㨪ᐔᚑ 19 ᐕ 6 ᦬)
16㧕 ᣣᧄක↪↹௝Ꮏቇળ JAMIT ᄢળ 2007 ࡊࡠࠣ࡜ࡓᆔຬ(ᐔᚑ 19 ᐕ 1 ᦬㨪ᐔᚑ 19 ᐕ 7 ᦬)
17㧕 ᣣᧄ↢૕කᎿቇળઍ⼏ຬ(ᐔᚑ 19 ᐕ 4 ᦬㨪⃻࿷)18㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળኾ㐷ᆔຬ㐳(ᐔᚑ 19 ᐕ 5 ᦬㨪⃻࿷)19㧕 Computer Assisted Radiology and Surgery (CARS 2008), Program Committee member(ᐔᚑ 19
ᐕ 12 ᦬㨪ᐔᚑ 20 ᐕ 6 ᦬)
20㧕 ጘ㒂᧲ᵗකቇ⎇ⓥળ਎⹤ੱ(ᐔᚑ 19 ᐕ 12 ᦬㨪⃻࿷)21㧕 SPIE Medical Imaging 2009 meeting(2009.2 in Kissimmee, Florida) Program committee
member(ᐔᚑ 20 ᐕ 5 ᦬㨪⃻࿷)22㧕 ᣣᧄ੃≸↹௝⎇ⓥળ࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖಽ⑼ળ࡮࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖ♖ᐲ▤ℂࡑ࠾ࡘࠕ࡞
૞ᚑࡢ࡯ࠠࡦࠣࠣ࡞࡯ࡊᆔຬ(ᐔᚑ 20 ᐕ 8 ᦬㨪⃻࿷)23㧕 International Forum on Medical Imaging in Asia 2009, Advisory Board member(ᐔᚑ 20 ᐕ 9 ᦬㨪⃻࿷)
24㧕 Computer Assisted Radiology and Surgery (CARS 2009), Program Committee member(ᐔᚑ 20
ᐕ 12 ᦬㨪⃻࿷)25㧕 ๭ๆᯏ⢻ࠗࡔ࡯ࠫࡦࠣ⎇ⓥળ਎⹤ੱ(ᐔᚑ 20 ᐕ 12 ᦬㨪⃻࿷)26㧕 ᣣᧄක↪↹௝Ꮏቇળ JAMIT ᄢળ 2009 ࡊࡠࠣ࡜ࡓᆔຬ(ᐔᚑ 20 ᐕ 12 ᦬㨪⃻࿷)ේ ᱞผ㧦
1㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ↹௝ಽ⑼ળᆔຬ(㨪⃻࿷)2㧕 ක↪↹௝ᖱႎቇળᏱോℂ੐(㨪ᐔᚑ 20 ᐕ 5 ᦬)
3㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળኾ㐷ᆔຬ(㨪ᐔᚑ 19 ᐕ 5 ᦬)
4㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળᐙ੐⵬૒(ᐔᚑ 19 ᐕ 5 ᦬㨪⃻࿷)5㧕 ක↪↹௝ᖱႎቇળℂ੐(ᐔᚑ 20 ᐕ 5 ᦬㨪⃻࿷)๟ ะᩕ㧦
1㧕 International Forum on Medical Imaging in Asia 2009, Program Committee member(ᐔᚑ 20 ᐕ 9᦬㨪⃻࿷)2㧕 㔚ሶᖱႎㅢାቇળ 2009 ᐕ✚วᄢળࡊࡠࠣ࡜ࡓ✬ᚑᆔຬ(ᐔᚑ 20 ᐕ 12 ᦬㨪⃻࿷)㧙㧙

2㧕ቇળ㐿௅⮮↰ᑝᔒ㧦
1㧕 Asian Forum on Medical Imaging 2007 ᄢળ㐳(ᐔᚑ 19 ᐕ 1 ᦬㧘ᷣᎺፉ㧘㖧࿖)
3㧕ቇⴚ㔀⹹⮮↰ᑝᔒ㧦
1㧕 ࠦࡦࡇࡘ࡯࠲ᡰេ↹௝⸻ᢿቇળ✬㓸ᆔຬ㐳(㨪ᐔᚑ 20 ᐕ 9 ᦬)
2㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ⧷⺆⺰ᢥ⹹✬㓸ᆔຬળᆔຬ(ᐔᚑ 19 ᐕ 4 ᦬㨪ᐔᚑ 20 ᐕ 4 ᦬)
3㧕 㔚ሶᖱႎㅢାቇળ࡮๺ᢥ⺰ᢥ⹹✬㓸ᆔຬળ࡮ක↪↹௝․㓸ภ✬㓸೽ᆔຬ㐳(ᐔᚑ 19 ᐕ 9 ᦬㨪ᐔᚑ 20ᐕ 7 ᦬)
ේ ᱞผ㧦
1㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ✬㓸ᆔຬ(㨪ᐔᚑ 19 ᐕ 2 ᦬)
2㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ✬㓸ડ↹ᆔຬ(ᐔᚑ 19 ᐕ 2 ᦬㨪ᐔᚑ 20 ᐕ 2 ᦬)
3㧕 ක↪↹௝ᖱႎቇળ✬㓸ᆔຬ㐳(㨪ᐔᚑ 20 ᐕ 5 ᦬)
7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳⮮↰ᑝᔒ㧦1㧕 ක↪↹௝ㅪวࡈࠜ࡯࡜ࡓ(ᐔᚑ 18 ᐕ 1 ᦬㧘ችฎፉ㧘᜗ᓙ⻠Ṷ‫ޟ‬Clinical Application of Phase Contrast
X-ray‫ޠ‬㧒‫ޟ‬Solid State Thick Film X-ray Image Sensor‫ޠ‬ᐳ㐳)2㧕 ╙ 13 ࿁ Nishiowari Radiological Technology Seminar(2006 ᐕ 2 ᦬㧘৻ች㧘․೎⻠Ṷ‫࡯ࡘࡇࡦࠦޟ‬࠲ᡰេ⸻ᢿ(CAD㧕ߩ⃻⁁ߣ዁᧪‫ޠ‬Ṷ⠪)
3㧕 ᧲ᶏ࿾ၞࠢ࡜ࠬ࠲࡯ࡈࠜ࡯࡜ࡓ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘‫ޟ‬ක≮↹௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ੐ᬺൻ‫ޠ‬Ṷ⠪)‫࡜ࠣࡕࡦࡑ࡞࠲ࠫࠖ࠺ޟ‬4㧕 ᣣᧄ᡼኿✢ᛛⴚቇળቇⴚᄢળ࡮╙ 59 ࿁↹௝ಽ⑼ળ(ᐔᚑ 18 ᐕ 4 ᦬㧘ᮮᵿ㧘ࡈࠖ⎇ⓥ߳ߩᦼᓙߣ⺖㗴‫ޠ‬Ṷ⠪)5㧕 Neusoft Research in Northeastern University(2006.05, Shenyang, Development ofcomputer-aided diagnosis in Japan and at Fujita Lab.; Invited speaker)
6㧕 20th. International congress and exhibition of computer assisted radiology and surgery,CARS2006(2006.06, Osaka, Development of breast CAD and its clinical applications in Japan;
Invited speaker㧕
7㧕 2nd. International symposium on future CAD(2006.07, Osaka, Digital representation ofdiagnostic knowledge: Anatomical structure in human torso region; Speaker)
8㧕 ╙ 10 ࿁ጘ㒂ࠪࡦࡐࠫ࠙ࡓ‫ޡ‬IT ߣࡠࡏ࠶࠻ߢ⸻ࠆ࡮ᴦߔ̆ࡠࡏ࠹ࠖ࠶ࠢవ┵ක≮‫(ޢ‬ᐔᚑ 18 ᐕ 7 ᦬㧘ጘ㒂㧘‫∛ޟ‬ᄌ⊒⷗ߢฬකߦߖ߹ࠆ㧍㧙ࠦࡦࡇࡘ࡯࠲߇↹௝⸻ᢿࠍᡰេߒ߹ߔ㧙‫ޠ‬Ṷ⠪㧘ᐳ㐳)9㧕 ╙ 2 ࿁ᣣᧄ᡼኿✢ᛛⴚቇળ࡮ᣣᧄ౮⌀ቇળ౒ห㐿௅ࠪࡦࡐࠫ࠙ࡓ(ᐔᚑ 18 ᐕ 7 ᦬㧘ᄢ㒋㧘ࡄࡀ࡞࠺ࠖࠬࠞ࠶࡚ࠪࡦ‫੃ޟ‬ᚱ↹௝ߩࡕ࠾࠲࡯⸻ᢿߩ⃻⁁ߣ዁᧪‫ޠ‬ᐳ㐳)‫ޟ‬਎⇇ߣᣣ
10㧕 ╙ 25 ࿁ᣣᧄක↪↹௝Ꮏቇળᄢળࠪࡦࡐࠫ࠙ࡓ‫ޟ‬CAD ߩᣂዷ㐿‫(ޠ‬ᐔᚑ 18 ᐕ 7 ᦬㧘੩ㇺ㧘ᧄߦ߅ߌࠆ CAD ߩ⃻⁁㧔✚᜝㧕‫ޠ‬Ṷ⠪)
11㧕 World congress on medical physics and biomedical engineering 2006, CAD workshop on “Toward
the realization of computer aided diagnosis in patient care: Experiences and future role ofacademic institutions and industry”(2006.08, Seoul, Recent CAD research projects in Japan,
Speaker & Chair)12㧕 6th Symposium of the Scandinavian Japan radiological society (2006.09, Stockholm, Opening
lecture: CAD in Japan; Speaker)
13㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ╙ 22 ࿁ࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ㧔CAD㧕࠮ࡒ࠽࡯㧦ਛ⚖✬(ᐔᚑ 18 ᐕ 9 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫ޟ‬Recent CAD research projects in Japan‫ޠ‬Ṷ⠪)
14㧕 MeVis at the University of Bremen(2006.10, Bremen, Invited lecture based on a guest
professorship: Overview of CAD research at Fujita Lab. in Gifu University; Speaker)
15㧕 ╙ 15 ࿁ᣣᧄࠦࡦࡇࡘ࡯࠲ᄖ⑼ቇળᄢળ࡮╙ 16 ࿁ࠦࡦࡇࡘ࡯࠲ᡰេ↹௝⸻ᢿቇળᄢળ(ᐔᚑ 18 ᐕ 10᦬㧘᧲੩㧘วหࠪࡦࡐࠫ࠙ࡓ‫ޟ‬ጘ㒂࡮ᄢ၂࿾ၞ ࡠࡏ࠹ࠖ࠶ࠢవ┵ක≮ࠢ࡜ࠬ࠲࡯ߩ⃻⁁ߣ዁᧪‫ޠ‬㧘‫↹ޟ‬௝⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒‫ޠ‬Ṷ⠪㧘ᐳ㐳)16㧕 ㊄ᴛᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼଻ஜቇኾ᡹‫ޟ‬㝯ജ޽ࠆᄢቇ㒮ᢎ⢒ࠗ࠾ࠪࠕ࠹ࠖࡉ FD ࡈࠜ࡯࡜ࡓ‫(ޠ‬ᐔ㧙㧙ᚑ 18 ᐕ 12 ᦬㧘㊄ᴛ㧘‫ޟ‬ቇ㓙⊛⎇ⓥࡊࡠࠫࠚࠢ࠻ߦࠃࠆੱ᧚⢒ᚑ‫⻠ޠ‬Ṷ)17㧕 State-of-the-art on computer-aided diagnosis: Past, present, and future(2007.02, Invited speakerat the Department of Computer Science, the University of South Carolina)
18㧕 Latest research on computer-aided diagnosis in Gifu University (2007.04, ⪇௟ᄢቇ㧘⻠Ṷ)
19㧕 Medical Imaging and Informatics (MIMI 2007)(2007.08, Beijing, Workshop: Computer-aided
diagnosis (CAD), Workshop organizer, chair, and speaker)
20㧕 ╙ 35 ࿁ᣣᧄ᡼኿✢ᛛⴚቇળ⑺ቄቇⴚᄢળ࡮╙ 43 ࿁ᣣᧄකቇ᡼኿✢ቇળ⑺ቄ⥃ᐥᄢળ(ᐔᚑ 19 ᐕ 10᦬㧘ฬฎደ㧘วห․೎⻠Ṷ㧦࠻࡛࠲⥄േゞ㧔ᩣ㧕ᛛ⋙ ᨋ ධ౎ ᳁㧦‫↥↢࠲࡛࠻ޟ‬ᣇᑼߩᧄ⾰ߣㅴൻ(ᷓൻ) -ᬺ⒳ࠍ໧ࠊߕዷ㐿ߢ߈ࠆ㧦TOYOTA WAY-‫ޠ‬มળ)
21㧕 ╙ 17 ࿁ࠦࡦࡇࡘ࡯࠲ᡰេ↹௝⸻ᢿቇળᄢળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ᐢፉ㧘CADM ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬CAD
ߩ⮎੐ᛚ⹺‫ޠ‬ᐳ㐳)22㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળ㧔MI㧕(ᐔᚑ 19 ᐕ 9 ᦬㧘ඳᄙ㧘․೎⻠Ṷ‫ޟ‬᡼኿శߦࠃࠆකቇࠗࡔ
࡯ࠫࡦࠣ‫ޠ‬ᐳ㐳)23㧕 㔚ሶᖱႎㅢାቇળක↪↹௝⎇ⓥળ㧔MI㧕(ᐔᚑ 19 ᐕ 11 ᦬㧘㊄ᴛ㧘ࡈࠚࡠ࡯⸥ᔨ⻠Ṷ‫ߪ࡞࠻ࠗ࠲ޟ‬↢૕ᯏ⢻⸘᷹ߣߒߡߺ߹ߒߚ‫ޠ‬ᐳ㐳)24㧕 ╙ 17 ࿁ᣣᧄ੃≸ᬌ⸻ቇળ✚ળ(ᐔᚑ 19 ᐕ 11 ᦬㧘ᮮᵿ㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬New modality ߦࠃࠆ੃≸ᬌ⸻ߩน⢻ᕈࠍតࠆ‫)࠻ࠬࠫࡐࡦࠪޠ‬25㧕 㔚ሶᖱႎㅢାቇળ࡮ක↪↹௝⎇ⓥળ(ᐔᚑ 20 ᐕ 1 ᦬㧘ᴒ✽㧘․೎⻠Ṷ‫ޟ‬New Approaches for Ultrasonic
Breast Imaging‫ޠ‬෸߮‫ޟ‬Computer-aided Diagnosis for 2D, 3D, and Whole Breast Ultrasound‫ޠ‬มળ)26㧕 ක↪↹௝ᖱႎቇળᐔᚑ 19 ᐕᐲᤐቄ㧔╙ 150 ࿁㧕ᄢળ(ᐔᚑ 20 ᐕ 2 ᦬㧘ᄢ㒋㧘․೎⻠Ṷ‫ޟ‬ක↪↹௝ᖱႎቇળᄢળ 150 ࿁ߩᱠߺ‫ޠ‬ᐳ㐳)27㧕 ╙ 15 ࿁ᣣᧄ CT ᬌ⸻ቇળቇⴚ㓸ળ(ᐔᚑ 20 ᐕ 2 ᦬㧘᧲੩㧘ࠪࡦࡐࠫ࠙ࡓΣ‫ޟ‬CAD ߣ CT ᬌ⸻‫ࠪޠ‬ࡦࡐࠫࠬ࠻)
28㧕 ╙ 11 ࿁ Radiology Update ⻠Ṷળ(ᐔᚑ 20 ᐕ 3 ᦬㧘ᄢ㒋㧘᜗ᓙ⻠Ṷ‫↹ޟ‬௝⸻ᢿߦ߅ߌࠆࠦࡦࡇࡘ࡯
࠲ᡰេ⸻ᢿ㧔CAD㧦Computer-aided diagnosis)ߩ⃻⁁ߣ዁᧪‫ޠ‬Ṷ⠪㧕29㧕 ╙ 64 ࿁ᣣᧄ᡼኿✢ᛛⴚቇળ✚ળቇⴚᄢળ(ᐔᚑ 20 ᐕ 4 ᦬㧘ᮮᵿ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᬌ⸻ߦ߅ߌࠆ CAD‫ޠ‬Ṷ⠪)
30㧕 ᣣᧄ᡼኿✢ᛛⴚቇળ╙ 63 ࿁↹௝ಽ⑼ળ(ᐔᚑ 20 ᐕ 4 ᦬㧘ᮮᵿ㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬⢷ㇱࠦࡦࡇࡘ࡯࠲ᡰ
េ⸻ᢿ㧔CAD)ߩ㜞ᐲൻߣ዁᧪‫࠻ࠬࠫࡐࡦࠪޠ‬㧕31㧕 ක↪↹௝ᖱႎᴺቇળᐔᚑ 20 ᐕᐲᐕᰴ㧔╙ 151 ࿁㧕ᄢળ(ᐔᚑ 20 ᐕ 5 ᦬㧘ጘ㒂㧘ᛛⴚ࠮ࡒ࠽࡯ᐳ㐳)32㧕 ╙ 10 ࿁ᾢᧄ↹௝⸻ᢿ࠹ࠢࡁࡠࠫ࡯⎇ⓥળ(ᐔᚑ 20 ᐕ 7 ᦬㧘ᾢᧄ㧘․೎⻠Ṷ‫࠲࡯ࡘࡇࡦࠦޟ‬ᡰេ⸻ᢿߩ⃻⁁ߣ⺖㗴‫ޠ‬Ṷ⠪)33㧕 MI ⎇(ᐔᚑ 20 ᐕ 7 ᦬㧘ᧅᏻ㧘․೎⻠Ṷ‫ޟ‬ᖱႎࡀ࠶࠻ࡢ࡯ࠢߦࠃࠆ࿾ၞක≮ࠨࡐ࡯࠻‫ޠ‬ᐳ㐳)34㧕 ᣣᧄ੃≸↹௝⎇ⓥળ╙ 10 ࿁࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖಽ⑼ળ(ᐔᚑ 20 ᐕ 8 ᦬㧘ฬฎደ㧘․೎⻠Ṷ‫ޟ‬ን჻ࡈࠗ࡞ࡓߩ⋥ធᄌ឵ᣇᑼ࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖߦߟ޿ߡ‫ޠ‬มળ)35㧕 ╙ 28 ࿁ක≮ᖱႎቇㅪวᄢળ㧔╙ 9 ࿁ᣣᧄක≮ᖱႎቇⴚᄢળ㧕(ᐔᚑ 20 ᐕ 11 ᦬㧘ᮮᵿ㧘ࠪࡦࡐࠫ࠙
ࡓ‫ޟ‬CAD ታ↪ൻߩ⃻⁁ߣ዁᧪ዷᦸ‫ޠ‬Ṷ⠪)ේ ᱞผ㧦
1㧕 ᣣᧄ᡼኿✢ᛛⴚቇળቇⴚᄢળ(ᐔᚑ 18 ᐕ 4 ᦬㧘ᮮᵿ㧘ࡕ࡯࠾ࡦࠣ࠮ࡒ࠽࡯‫࠲࡯ࡘࡇࡦࠦޟ‬ᡰេ⸻ᢿߦߟ޿ߡ‫ޠ‬㧘ᐳ㐳)2㧕 ᣣᧄ᡼኿✢ᛛⴚቇળቇⴚᄢળ(ᐔᚑ 20 ᐕ 4 ᦬㧘ᮮᵿ㧘ࠪࡦࡐࠫ࠙ࡓ‫ࡦࠝߣࡉࠚ࠙ࠢ࠶ࠖ࠹ࡦࡑ࠮ޟ‬㧘Ṷ⠪)࠻ࡠࠫ࡯ ᖱႎ῜⊒ᤨઍߩ㆏ᮡ‫ޠ‬๟ ะᩕ㧦
1㧕 ╙ਃ࿁․ቯ㗔ၞ‫ޟ‬⍮⊛↹௝⸻ᢿᡰេ‫(ࡓ࠙ࠫࡐࡦࠪޠ‬ᐔᚑ 18 ᐕ 1 ᦬㧘੩ㇺ㧘ᱜᏱ᭴ㅧߩℂ⸃ߦၮߠߊ⍮⊛ CAD㧙⎇ⓥᚑᨐ᭎ⷐ̆㧘Ṷ⠪)8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫ1㧕 Hara T, Fujita H, et al.: SPIE Medical Imaging 2006 ߦ߅޿ߡ Honorable Mention Poster Award⾨(ᐔᚑ 18 ᐕ 2 ᦬)
2㧕 Zhou X, Hara T, Fujita H, et al.: 2006 ᐕർ☨කቇ᡼኿✢ቇળ㧔RSNA2006㧕ߩ Education Exhibit㧙㧙Excellence in Design ⾨(ᐔᚑ 18 ᐕ 11 ᦬)
3㧕 Hara T, Fujita H, et al. : Cum Laude Poster Award (SPIE Medical Imaging 2007 Symposium) (ᐔᚑ 19 ᐕ 2 ᦬)
4㧕 Hara T, Fujita H, et al. : Honorable Mention Poster Award (SPIE Medical Imaging 2007
Symposium) (ᐔᚑ 19 ᐕ 2 ᦬)
5㧕 ේ ᱞผ㧘⮮↰ᑝᔒ㧘ઁ㧦╙ 63 ࿁ᣣᧄ᡼኿✢ᛛⴚቇળ✚ળቇⴚᄢળߦ߅޿ߡ㊄⾨㧔㔚ሶࡐࠬ࠲㧕(ᐔᚑ 19 ᐕ 4 ᦬)
6㧕 ේ ᱞผ㧘⮮↰ᑝᔒ㧘ઁ㧦╙ 64 ࿁ᣣᧄ᡼኿✢ᛛⴚቇળ✚ળቇⴚᄢળߦ߅޿ߡ㌃⾨㧔㔚ሶࡐࠬ࠲㧕(ᐔᚑ 19 ᐕ 4 ᦬)
7㧕 ේ ᱞผ㧘⮮↰ᑝᔒ㧘ઁ㧦ක↪↹௝ᖱႎቇળ ౝ↰⺰ᢥ⾨(ᐔᚑ 19 ᐕ 6 ᦬)
8㧕 ේ ᱞผ㧘๟ ะᩕ㧘ઁ㧦ක↪↹௝ᖱႎቇળ ㊄᫪ᅑബ⾨(ᐔᚑ 19 ᐕ 6 ᦬)
9㧕 ๟ ะᩕ㧘ේ ᱞผ㧘⮮↰ᑝᔒ㧘ઁ㧦㔚ሶᖱႎㅢାቇળ࡮ቇⴚᅑബ⾨㧔2007 ᐕ㔚ሶᖱႎㅢାቇળ✚ળᄢળ⻠Ṷߦኻߒߡ㧕(ᐔᚑ 20 ᐕ 3 ᦬)
10㧕 ⮮↰ᑝᔒ㧦ᣣᧄ᡼኿✢ᛛⴚቇળ࡮ቇⴚ⾨(ᐔᚑ 20 ᐕ 4 ᦬)
11㧕 Hara T, Fujita H, et al.: 2008 ᐕർ☨කቇ᡼኿✢ቇળ㧔RSNA2008㧕ߩ Education Exhibit ߦ߅޿ߡ‫ޟ‬Certificate of Merit‫(⾨ޠ‬ᐔᚑ 20 ᐕ 12 ᦬)
9㧚␠ળᵴേ
⮮↰ᑝᔒ㧦
1㧕 ⽷࿅ᴺੱ ጘ㒂⋵⎇ⓥ㐿⊒⽷࿅ ⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ੐ᬺ ጘ㒂࡮ᄢ၂࿾ၞߦ߅ߌࠆ⍮⊛ࠢ࡜ࠬ࠲࡯ផ
ㅴળ⼏ᆔຬ(㨪ᐔᚑ 20 ᐕᐲ)
2㧕 ⽷࿅ᴺੱ ጘ㒂⋵⎇ⓥ㐿⊒⽷࿅ ⍮⊛ࠢ࡜ࠬ࠲࡯ഃᚑ੐ᬺ ጘ㒂࡮ᄢ၂࿾ၞߦ߅ߌࠆ⍮⊛ࠢ࡜ࠬ࠲࡯⍮⊛⽷↥ᚢ⇛ળ⼏ᆔຬ(ᐔᚑ 18 ᐕᐲ㨪ᐔᚑ 20 ᐕᐲ)
3㧕 ⽷࿅ᴺੱ ጘ㒂⋵⎇ⓥ㐿⊒⽷࿅ ᐔᚑ 18 ᐕᐲ࿾ၞᣂ↢ࠦࡦ࠰࡯ࠪࠕࡓ⎇ⓥ㐿⊒੐ᬺ㧔⌒ᐩ┙૕↹௝ࠍ↪޿ߚ⌒⑼ஜᐽ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒㧕ᆔຬળ㧔⌒ᐩ↹௝⸻ᢿ㐿⊒ᆔຬળ㧕ᆔຬ(ᐔᚑ 18 ᐕ 9᦬㨪ᐔᚑ 19 ᐕᐲ)ේ ᱞผ㧦
1㧕 ጘ㒂⋵ᢎ⢒ᆔຬળ IT ੱ᧚⢒ᚑࡊࡠࠫࠚࠢ࠻ㆇ༡ᜰዉᆔຬ(㨪ᐔᚑ 19 ᐕ 3 ᦬)
10㧚ႎ๔ᦠ
1㧕 ⍹၂ᱞ↵㧘ችဈ๺↵㧘⷏⼱ ᒄ㧘દ⮮ᤐᶏ㧘㆙⮮⊓༑ሶ㧘᧛↰༑ઍผ㧘቟⮮ ⵨㧘ዊኹศⴤ㧘ᳰ↰ల㧘ፉᧄ૫ኼᐢ㧘⮮↰ᐢᔒ㧘የㄞ⑲┨㧘ᬮᧄ᣽ᒾ㧘ේ ⋿ດ㧘૒‫ᧁޘ‬ᐽᄦ㧘ᷰㄝ⑲ᐘ㧘ട⮮సᒾ㧦ᮡḰ⊛㔚ሶࠞ࡞࠹ߦ߅ߌࠆ↹௝ⷰኤᶧ᥏ࡕ࠾࠲㧘᳢↪ᶧ᥏ࡕ࠾࠲ߩᮡḰൻߣ♖ᐲ▤ℂߦ㑐ߔࠆ⎇ⓥ㧘
ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄࡮ක≮ᛛⴚ⹏ଔ✚ว⎇ⓥ੐ᬺ㧘ᐔᚑ 15 ᐕᐲ㧙ᐔᚑ 17 ᐕᐲ✚ว⎇ⓥႎ๔ᦠ㧔⍹၂⃰㧕㧦1㧙88(2006 ᐕ 3 ᦬)
2㧕 ⍹၂ᱞ↵㧘ችဈ๺↵㧘⷏⼱ ᒄ㧘㆙⮮⊓༑ሶ㧘᧛↰༑ઍผ㧘቟⮮ ⵨㧘ዊኹศⴤ㧘ᳰ↰ ల㧘ፉᧄ૫ኼᐢ㧘⮮↰ᐢᔒ㧘የㄞ⑲┨㧘ᬮᧄ᣽ᒾ㧘ේ ⋿ດ㧘૒‫ᧁޘ‬ᐽᄦ㧘ᷰㄝ⑲ᐘ㧦ᮡḰ⊛㔚ሶࠞ࡞࠹ߦ
߅ߌࠆ↹௝ⷰኤᶧ᥏ࡕ࠾࠲㧘᳢↪ᶧ᥏ࡕ࠾࠲ߩᮡḰൻߣ♖ᐲ▤ℂߦ㑐ߔࠆ⎇ⓥ㧘ෘ↢ഭ௛⑼ቇ⎇ⓥ
⾌⵬ഥ㊄࡮ක≮ᛛⴚ⹏ଔ✚ว⎇ⓥ੐ᬺ㧘ᐔᚑ 17 ᐕᐲ✚᜝ႎ๔ᦠ㧔⍹၂⃰㧕㧦1㧙51(ᐔᚑ 18 ᐕ 3 ᦬)
3㧕 ✽㊁ ❥㧦࠺ࠫ࠲࡞↹௝ࠍ೑↪ߒߚ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ㧔✽㊁ ❥㧘㐳⼱Ꮉ⚐৻㧘ᷡ᳓ᤘિ㧘ᧃ᳗ᐽੳ㧘⮮↰ᐢᔒ㧘ฬข ඳ㧘๺↰⌀৻㧘ੳᧁ ⊓㧘◉ፒ⾫ᴦ㧕㧦ෘ↢ഭ௛⋭
߇ࠎ⎇ⓥഥᚑ㊄ߦࠃࠆ⎇ⓥႎ๔㓸㧔ᐔᚑ 17 ᐕᐲ㧕ᯏ᪾㐿⊒⎇ⓥ㧦467㧙471(ᐔᚑ 18 ᐕ 9 ᦬)
4㧕 ᄢౝᙗ᣿㧦ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄ߦࠃࠆ੃߇ࠎᬌ⸻ߩ♖ᐲ෸߮ല₸ะ਄ߦ㑐ߔࠆ⎇ⓥ㧔15-14㧕㧘✚ว⎇ⓥႎ๔㧔ᐔᚑ 15㨪18 ᐕᐲ㧕㧘ಽᜂ㧦⮮↰ᑝᔒ㧦34㧙37㧘102㧙104(2007 ᐕ 3 ᦬)
5㧕 ✽㊁ ❥㧦࠺ࠫ࠲࡞↹௝ࠍ೑↪ߒߚ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ㧔✽㊁ ❥㧘㐳⼱Ꮉ⚐৻㧘ᷡ᳓ᤘિ㧘ᧃ᳗ᐽੳ㧘⮮↰ᐢᔒ㧘ฬข ඳ㧘๺↰⌀৻㧘ੳᧁ ⊓㧘◉ፒ⾫ᴦ㧕㧦ෘ↢ഭ௛⋭
߇ࠎ⎇ⓥഥᚑ㊄ߦࠃࠆ⎇ⓥႎ๔㓸㧔ᐔᚑ 18 ᐕᐲ㧕ᯏ᪾㐿⊒⎇ⓥ㧦405㧙409(2007 ᐕ 9 ᦬)
6㧕 ✽㊁ ❥㧦࠺ࠫ࠲࡞↹௝ࠍ೑↪ߒߚ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ㧔✽㊁ ❥㧘㐳⼱Ꮉ⚐৻㧘ዊ⇌⑲ᢥ㧘ᷡ᳓ᤘિ㧘ᧃ᳗ᐽੳ㧘ᳰ↰ ల㧘⮮↰ᐢᔒ㧘ฬข ඳ㧘᫪ 㓷᮸㧘๺↰⌀৻㧘ੳᧁ ⊓㧘ጊᧄ⋿ม㧘⑔ፉ㊀ᑝ㧘◉ፒ⾫ᴦ㧕㧦ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄ߦࠃࠆ⎇ⓥႎ๔㓸(ᐔᚑ 18ᐕᐲ)ᯏ᪾㐿⊒⎇ⓥ㧦665㧙667(2007 ᐕ 9 ᦬)
7㧕 ⮮↰ᐢᔒ㧘ේ ᱞผ㧘๟ ะᩕ㧘᩿↢ᜏม㧘౗᧻㓷ਯ㧘ᓟ⮮⵨ᄦ㧘ᤊ ඳᤘ㧘᧘ ㎬▸㧘૒੗◊௾㧘㧙㧙⑔ጟᄢテ㧘⇌ਛ⵨ม㧘᧻ේ෹ሶ㧘㆙⮮⊓༑ሶ㧦ᱜᏱ᭴ㅧߩℂ⸃ߦၮߠߊ⍮⊛ CAD㧘II-109-II-121㧘
(2008)㧚
‫ޟ‬ᄙᰴరක↪↹௝ߩ⍮⊛⸻ᢿᡰេ‫ޠ‬㧔㗔ၞ 424㧕㧘ᐔᚑ 15 ᐕᐲ߆ࠄᐔᚑ 18 ᐕᐲ㧘⑼ቇ⎇ⓥ⾌
⵬ഥ㊄㧔․ቯ㗔ၞ⎇ⓥ㧕⎇ⓥᚑᨐႎ๔ᦠ㧘㗔ၞઍ⴫⠪࡮ዊ⇌⑲ᢥ(ᐔᚑ 20 ᐕ 3 ᦬)㧚
8㧕 㐳⼱Ꮉ⚐৻㧦࠺ࠫ࠲࡞↹௝ಣℂߦࠃࠆ߇ࠎ⸻ᢿᡰេࠪࠬ࠹ࡓߩ㐿⊒ߣ೑↪ߦ㑐ߔࠆ⎇ⓥ㧔㐳⼱Ꮉ⚐৻㧘ੳᧁ ⊓㧘⮮↰ᐢᔒ㧘ᷡ᳓ᤘિ㧘᫪ ஜ╷㧘✽㊁ ❥㧘᫪ 㓷᮸㧘◉ፒ⾫ᴦ㧘᧛᧻ᐘ↵㧘᧻ㄼᱜ᮸㧕㧦ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄ߦࠃࠆ⎇ⓥႎ๔㓸㧔ᐔᚑ 19 ᐕᐲ㧕ᯏ᪾㐿⊒⎇ⓥ㧦396㧙401 (2008ᐕ 9 ᦬)
9㧕 ⍹ᯅᔘม㧦࠺ࠫ࠲࡞ࡑࡦࡕࠣ࡜ࡈࠖߦࠃࠆ੃߇ࠎᬌ⸻ߩല₸෸߮♖ᐲะ਄࡮⹏ଔߦ㑐ߔࠆ⎇ⓥ㧔⍹㧦ෘ↢ഭ௛⋭߇ࠎ⎇ⓥഥᚑ㊄ߦࠃᯅᔘม㧘ᄢ⽾ᐘੑ㧘ᬀ᧻ቁᖝ㧘᧻ᧄ᡽㓶㧘ౝጊ⩿ᥓሶ㧘ේ ᱞผ㧕ࠆ⎇ⓥႎ๔㓸㧔ᐔᚑ 19 ᐕᐲ㧕⸘↹⎇ⓥ㧦326㧙330(2008 ᐕ 9 ᦬)
11㧚ႎ㆏
1㧕 ⮮↰ᑝᔒ㧦ᦨవ┵ක≮ߩ㝯ജࠍ⚫੺‫ޟ‬IT ߣࡠࡏ࠶࠻ߢ⸻ࠆ࡮ᴦߔ‫ޠ‬㧦⺒ᄁᣂ⡞(2006 ᐕ 7 ᦬ 8 ᣣ)
2㧕 ⮮↰ᑝᔒ㧦੃߇ࠎࠍ⍫ශ⴫␜㧦ࠦࡦࡇࡘ࡯࠲࡯⸻ᢿࠍᚻഥߌ ⿥㖸ᵄ↹௝ಽᨆ㧦⺒ᄁᣂ⡞(2006 ᐕ 7
᦬ 26 ᣣ)3㧕 ේ ᱞผ㧦ᄢ๺⸽೛ࡋ࡞ࠬ⽷࿅ ᠟ᓇᴺ PET ⎇ⓥ㧦ጘ㒂ᣂ⡞(2006 ᐕ 11 ᦬ 10 ᣣ)
4㧕 㨪ࠬ࠹࡟ࠝ⌒ᐩࠞࡔ࡜㨪ⷞ␹⚻੃㗡ߩᒻ⁁⸃ᨆߦ᦭↪㧔╙ 18 ࿁ᣣᧄ✛ౝ㓚ቇળ㧕㧦Medical
Tribune(2007 ᐕ 11 ᦬ 22 ᣣ)
5㧕 ੃߇ࠎᬌᩏ߁ߟ߱ߖߢ ⿥㖸ᵄ⸻ᢿᡰេ ࠕࡠࠞߣጘ㒂ᄢ㐿⊒㧦ᣣ⚻↥ᬺᣂ⡞(2008 ᐕ 7 ᦬ 23 ᣣ)෸߮หᣣઃߌᣣ⚻࠽ࡆ
6㧕 ⮮↰ᑝᔒ㧦੃߇ࠎ⼂೎ ᡰេ࠰ࡈ࠻㧦ᦺᣣᣂ⡞㧔2008 ᐕ 12 ᦬ 26 ᣣ㧕෸߮ 12 ᦬ 31 ᣣઃߌ asahi.com
㧔੃߇ࠎ߆߽ ↹௝⸻ᢿ කᏧ⵬ഥߔࠆ࠰ࡈ࠻㐿⊒㧕12㧚⥄Ꮖ⹏ଔ
⹏ଔ⑼⎇⾌ߦࠃࠆၮ␆⎇ⓥ㧘↥ቭቇߦࠃࠆᄢဳ⎇ⓥ㧘߅ࠃ߮ડᬺߣߩ↥ቇ౒หߦࠃࠆታ↪ൻ⎇ⓥࠍ᏷ᐢߊⴕߞߡ߅ࠅ㧘ߎࠇࠄߩߔߴߡߦ߅޿ߡ⎇ⓥߩㅴ᝞⁁ᴫߪ㧘ᄖㇱ⹏ଔߩ⚿ᨐ߽㜞ߊ㧘✚ߓߡᭂ߼ߡ㗅⺞ߢ޽ࠆ‫੹ޕ‬ᓟ߽ߎߩࡍ࡯ࠬߢ㧘ߐࠄߦකᎿㅪ៤ࠍၮ⺞ߣߒߚ౒ห⎇ⓥࠍㅴ߼ࠆ⸘↹ߢ޽ࠅ㧘ක↪↹௝ᖱႎ
ಣℂಽ㊁ߦ߅ߌࠆ਎⇇⊛࡟ࡌ࡞ߩቇⴚ⎇ⓥߩផㅴ㧘߅ࠃ߮ߘߩ␠ળ߳ߩㆶరߦദജߒߡ޿߈ߚ޿‫ޕ‬ቇ↢ߩ⎇ⓥᜰዉ࡮ᢎ⢒㕙ߢߪ㧘ᐕ㑆 100 ઙࠍ⿥ߔ࿖ౝᄖߩቇળ╬ߦ߅ߌࠆ⎇ⓥ⊒⴫ߥߤߦࠃࠆ⢒ᚑㆊ⒟ࠍㅢ
ߓߡ㧘㜞޿࡟ࡌ࡞ߩᢎ⢒࡮⎇ⓥᵴേࠍⴕߞߡ߅ࠅ㧘ਥߥዞ⡯ડᬺవ߆ࠄߩ⹏್߽᭎ߒߡ⦟ᅢߢ޽ࠅ㧘㜞ߊ⹏ଔߐࠇߡ޿ࠆ‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷⃻࿷㧘ᧄಽ㊁ߩᢎຬ 3 ฬ߇㧘Ꮏቇㇱᔕ↪ᖱႎቇ⑼ߦ಴ะ߈㧘ᄙߊߩ⻠⟵߿ታ㛎ࠍᜂᒰߒ㧘߆ߟතᬺ⎇ⓥߩᜰዉ㧔Ფᐕቇㇱ 3 ᐕᰴߩ⑺߆ࠄቇ↢㈩ዻ㧔Ფᐕ 10 ฬᒙ⒟ᐲ㧕߇ᆎ߹ࠅ㧘4 ᐕᰴතᬺ߹ߢߩ㑆ߩ 1 ᐕඨߩᦼ㑆㧕ࠍⴕߞߡ޿ࠆ‫ߩࠄࠇߎޕ‬ቇ↢߇ᄢቇ㒮ㅴቇᤨߦౣ↢ක⑼ቇኾ᡹ߩඳ჻೨ᦼ⺖⒟ߦ౉ቇߒ㧘৻ㇱߪᓟᦼ⺖⒟ߦ߹ߢㅴቇߒߡ޿ࠆ߇㧘ઁᄢቇ߆ࠄߩ౉ቇ⠪ᢙߪᭂ߼ߡዋߥ޿⃻⁁ߢ޽ࠆ‫੹ޕ‬ᓟߪઁᄢቇ
ߦ߽ᐢߊᐢႎࠍⴕ޿㧘᏷ᐢߊో࿖ⷙᮨߢఝ⑲ߥቇ↢ߩ൐㓸ߦോ߼ߚ޿‫ޕ‬໧㗴ὐߣߒߡߪ㧘ਥߦᎿቇ♽߆ࠄߩᄙߊߩቇ↢ࠍฃߌ౉ࠇߡ޿ࠆ߇㧔2008 ᐕᧃߢ㧘ඳ჻ᓟᦼ⺖⒟ 7 ฬ㧘ඳ჻೨ᦼ⺖⒟ 16 ฬ㧘ቇㇱ 4 ᐕ↢ 6 ฬ㧘ቇㇱ 3 ᐕ↢ 7 ฬ㧦⸘ 36 ฬ㧕㧘ߎࠇࠄߩቇ↢ߩᢎ⢒࡮⎇ⓥߦߪ㧘ᢎຬ 3 ฬߩߺ߇ਛᔃߣߥߞߡⴕߞߡ޿ࠆߩ߇⃻⁁ߢ㧘߈߼⚦߆ߥᜰዉࠍߔࠆߦߪࠬ࠲࠶ࡈਇ⿷ߪุ߼ߥ
޿⁁ᘒߢ޽ࠆ‫ߚ߹ޕ‬㧘⎇ⓥቶߣߒߡ೑↪ߢ߈ࠆ⎇ⓥቶ࡮ታ㛎ቶߩⷙᮨ߇ᎿቇㇱߦᲧߴߡዊߐߊ㧘ߎࠇࠄ߇ᡷༀߐࠇࠆߎߣ߇ᦸ߹ࠇࠆ‫ޕ‬කᎿቇ♽޽ࠆ޿ߪකቇ♽ߩ࿖㓙ળ⼏ߦ߅ߌࠆ⊒⴫Ṷ㗴ᢙߪᐕ㑆 30 ઙࠍ⿥߃ߡ߅ࠅ㧘ዷ␜╬ߢߪⶄᢙߩ
⾨ࠍฃ⾨ߒߡ޿ࠆ߇㧘ߎࠇࠄߩ࿖㓙⹹߳ߩ⺰ᢥൻ߇ዋߒㆃࠇߡ޿ࠆ⁁ᴫߢ޽ࠅ㧘ᡷༀߦദ߼ࠆ‫ޕ‬੹ᓟߩዷᦸ⍮⊛ࠢ࡜ࠬ࠲࡯ࡊࡠࠫࠚࠢ࠻⎇ⓥࠍߪߓ߼㧘ขࠅ⚵ࠎߢ޿ࠆฦ⒳⎇ⓥߦ߅ߌࠆࠦࡦࡇࡘ࡯࠲ᡰេ⸻ᢿ
㧔CAD㧕ࠪࠬ࠹ࡓߩ㐿⊒㧘෸߮ߘߩታ↪ൻࠍߐࠄߦㅴዷߐߖࠆ‫ߚ߹ޕ‬㧘⃻࿷ߪ㧘᡼኿✢කቇߢขࠅᛒࠊ
ࠇࠆ⸻ᢿ↪ߩ↹௝㗔ၞࠍኻ⽎ߩਛᔃߣߒߡ⎇ⓥࠍㅴ߼ߡ޿ࠆ߇㧘੹ᓟߪ㧘ౣ↢ක⑼ቇ㑐ଥߩ↹௝ಣℂ࡮
⸃ᨆ࡮⹺⼂ߦ㑐ߔࠆ⎇ⓥ࠹࡯ࡑ߳ߩߐࠄߥࠆⓍᭂ⊛ߥขࠅ⚵ߺࠍᬌ⸛ߔࠆ‫ޕ‬ᢎ⢒㕙ߢߪߐࠄߦ߈߼⚦߆ߥᜰዉ૕೙ࠍ⏕┙ߒ㧘⥄ਥᕈ㧘ഃㅧᕈ㧘࠴ࡖ࡟ࡦࠫ♖␹ߦንࠎߛቇ↢ߩ⢒ᚑࠍ⋡ᜰߔ‫ޕ‬㧙㧙ާౣ↢ᔕ↪ቇ⻠ᐳި
㧔1㧕ᓴⅣ∛ᘒቇಽ㊁1㧚⎇ⓥߩ᭎ⷐ
1㧕ౣ↢කቇ
1㧕㛽㜑⚦⢩⒖ᬀߦࠃࠆᔃ╭᪪Ⴇ㧘㐽Ⴇᕈേ⣂⎬ൻ∝ߦኻߔࠆౣ↢කቇ࡮ක≮2㧕G-CSF㧔㗰☸⃿ࠦࡠ࠾࡯ೝỗ࿃ሶ㧕ߥࠄ߮ߦ Erythropoietin ࠍ↪޿ߚ⁜ᔃ∝࡮ᔃ╭᪪Ⴇ࡮ᔃਇో
㐽Ⴇᕈേ⣂⎬ൻ∝ߦኻߔࠆౣ↢≮ᴺߩ㐿⊒
3㧕Gelatin hydrogel ߩ Drug Delivery System ࠍ↪޿ߚౣ↢≮ᴺߩ㐿⊒
4㧕࡝ࡐ࠱࡯ࡓࠍ↪޿ߚ࠽ࡁකቇߦࠃࠆౣ↢≮ᴺߩ㐿⊒
5㧕ࡎ࡯ࡒࡦࠣ㑐ㅪಽሶ⊒⃻ᐙ⚦⢩ߦࠃࠆᔃ╭᪪Ⴇ࡮ᔃਇో࡮㐽Ⴇᕈേ⣂⎬ൻ∝ߦኻߔࠆౣ↢කቇ࡮ක≮2㧕ࠕࡐ࠻࡯ࠪࠬ࡮ࠝ࡯࠻ࡈࠔࠫ࡯
1㧕ᓴⅣེ∔ᖚߣࠕࡐ࠻࡯ࠪࠬ
⡺⧘⚵❱⚦⢩ࠕࡐ࠻࡯ࠪࠬ㒖ኂߦࠃࠆᔃ╭᪪ႧᓟᏀቶ࡝ࡕ࠺࡝ࡦࠣߩ੍㒐
2㧕ᓴⅣེ∔ᖚߣࠝ࡯࠻ࡈࠔࠫ࡯
㘫㙈࡮⯯ⴊࠬ࠻࡟ࠬ㧘ᔃਇోߦ߅ߌࠆᔃ╭⚦⢩ࠝ࡯࠻ࡈࠔࠫ࡯ߩ∛ᘒ↢ℂ
3㧕⣢∔ᖚߣࠕࡐ࠻࡯ࠪࠬ
♧ዩ∛ᕈ⣢∝ߩ⊒∝ࡔࠞ࠾࠭ࡓߦ߅ߌࠆࠕࡐ࠻࡯ࠪࠬߩᓎഀߩ⸃᣿
3㧕⯯ⴊᔃ╭଻⼔ߩࡔࠞ࠾࠭ࡓ⸃᣿ߣ new drug ߩ㐿⊒1㧕Ischemic preconditioning ߣ ischemic postconditioning ߩࡔࠞ࠾࠭ࡓ⸃᣿
2㧕᛫♧ዩ∛⮎ߢ޽ࠆ miglitol, acarbose, voglibose ߥߤD-glucosidase 㒖ኂ⮎㧘pioglitazone ߦࠃࠆ⯯ⴊᔃ╭଻⼔૞↪ߩࡔࠞ࠾࠭ࡓ⸃᣿
3㧕ฦ⒳ᔃⴊ▤⮎㧔ฦ⒳㒠࿶⮎㧘ࠬ࠲࠴ࡦ㧘᛫ⴊዊ᧼⮎㧕ߩ⯯ⴊᔃ╭଻⼔૞↪ߩࡔࠞ࠾࠭ࡓ⸃᣿
4㧕ㆮવሶᴦ≮1㧕ᔃਇోߦኻߔࠆ HGF, sFas, นṁᕈ TGF-Eฃኈ૕, Decorin ߩㆮવሶᴦ≮2㧕ᔃ╭᪪Ⴇߦኻߔࠆ HGF, ࡋࡄ࡝ࡦ⚿วဳ EGF ᭽Ⴧᱺ࿃ሶߩㆮવሶᴦ≮3㧕♧ዩ∛ᕈ⣢∝ߦኻߔࠆ HGF ㆮવሶᴦ≮5㧕IB-IVUS ߅ࠃ߮ IB-ࠛࠦ࡯ߦࠃࠆ⚵❱ᕈ⁁⸻ᢿ
1㧕㜞⢽ⴊ∝ᴦ≮⮎㧘ACE 㒖ኂ⮎ߩ౰േ⣂߅ࠃ߮㗖േ⣂ࡊ࡜࡯ࠢᕈ⁁ߦਈ߃ࠆᓇ㗀ߩ⸃ᨆ
2㧕౰േ⣂⎬ൻ∛ᄌߩ progression ߣ⚵❱∛ᄌ
3㧕⣢∔ᖚ∛ᄌߩ⣢⚵❱ᕈ⁁⸻ᢿ
4㧕ᔃᚱ⚦േ∝଀ߩᔃᚱ⚵❱ᕈ⁁⸻ᢿ
5㧕IB-IVUS ↹௝ߩ 3 ᰴరൻ
6㧕േ⣂⎬ൻ∝ߩ∛ᘒߦኻߔࠆಽሶ↢‛ቇ⊛ࠕࡊࡠ࡯࠴
1㧕LOX-1
7㧕3D-CT ߦࠃࠆ౰േ⣂∛ᄌ⸻ᢿ
1㧕3D-CT ↹௝ߣ IB-IVUS ↹௝ߣߩ⚵❱ᕈ⁁⸻ᢿᲧセ8㧕ਇᢛ⣂1㧕ࠞ࠹࡯࠹࡞ࠕࡉ࡟࡯࡚ࠪࡦߦࠃࠆฦ⒳㗫⣂ᕈਇᢛ⣂ᴦ≮
2㧕T-wave alternans ߣ sleep apnea ߩ㑐ଥ9㧕౰േ⣂ࠗࡦ࠲࡯ࡌࡦ࡚ࠪࡦ
1㧕ᚒ߇࿖ߦ߅ߌࠆ CAG, PCI, CABG ߅ࠃ߮ AMI ߩో࿖⺞ᩏ
2㧕⁜ᔃ∝ߦኻߔࠆ⮎‛≮ᴺ㧘PCI ߅ࠃ߮ CABG ߩ⃻⁁ߣࠦࠬ࠻3㧕J-SAP ⎇ⓥ
4㧕ᔃ⣢ㅪ㑐ߦ㑐ߔࠆ⎇ⓥ
10㧕 ⥃ᐥᩭකቇ
1㧕ᔃ╭᪪Ⴇ㧘⁜ᔃ∝㧘⢈ᄢဳᔃ╭∝㧘ੑᰴᕈᔃ╭∔ᖚ㧔ࠨ࡞ࠦࠗ࠼࡯ࠪࠬߥߤ㧕ߩᩭකቇ⊛ᬌ⸛
2㧕D㧙ࠣ࡞ࠦࠪ࠳࡯࠯㒖ኂ⮎ߩ⯯ⴊᔃ╭଻⼔૞↪ߩᩭකቇ⊛ᬌ⸛11㧕 ᧲ᵗකቇ⊛ࠕࡊࡠ࡯࠴
1㧕ᄤบὖ⮎ߩ⣢∔ᖚߦኻߔࠆലᨐߩᬌ⸛
12㧕 㑐ㅪ∛㒮ߣߩᄢⷙᮨ⥃ᐥ⹜㛎
1㧕౰ᡨ❗ᕈ⁜ᔃ∝ߩ੍ᓟ࿃ሶߩᬌ⸛㧙㧙

2㧕DES㧔Drug Eluting Stent㧕ᤨઍߦ߅ߌࠆ⮎‛≮ᴺߩᬌ⸛
3㧕ᣧᦺ㜞ⴊ࿶ߩ⣂ᜉᢙߦ㑐ߔࠆ⎇ⓥ
2㧚ฬ★
ᢎ᝼㧦
ಎᢎ᝼㧦
ಎᢎ᝼㧦
⻠Ꮷ㧦
⻠Ꮷ㧦
⥃ᐥ⻠Ꮷ㧦
⥃ᐥ⻠Ꮷ㧦

Ḋญା਽
┻᧛రਃ
⷏၂๺ᒾ
Ꮉፒ㓷ⷙ
㕍ጊ℉⏴
᧛↰৻⍮ᦶ
‐⿧ඳᤘ

Shinya Minatoguchi
Genzou Takemura
Kazuhiko Nishigaki
Masanori Kawasaki
Takuma Aoyama
Ichijiro Murata
Hiroaki Ushikoshi

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
1㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚II. ౰േ⣂∔ᖚ 1㧚ᕆᕈᔃ╭᪪Ⴇ㧦ጊญᔀ㧘ၳᱜੑ✬㧚ᓴⅣེ∔ᖚ ᦨᣂߩᴦ≮
2006-2007㧘᧲੩㧦ධᳯၴ㧧2006 ᐕ㧦57г62㧚
2㧕 ⷏၂๺ᒾ㧚㧙⑳ߪߎ߁ᴦ≮ߒߡ޿ࠆ㧦቟ቯ⁜ᔃ∝㧔ౝ⑼㧕
㧦੹ᣣߩᴦ≮ᜰ㊎ 2006 ᐕ 㧘᧲੩㧦කቇᦠ㒮㧧
2006 ᐕ㧦265г268㧚
3㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚PCI ߩㆡᔕߣ⑌ᔊ㧦శ⮮๺᣿✬㧚ᣂ⋡ߢ⷗ࠆᓴⅣེ∛ࠪ࡝࡯࠭ 20 ࠞ࠹࡯࠹࡞ࠗࡦ
࠲࡯ࡌࡦ࡚ࠪࡦ㧘᧲੩㧦ࡔࠫࠞ࡞ࡆࡘ࡯␠㧧2006 ᐕ㧦3642㧚
4㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚╙ 2 ┨ ⁜ᔃᕈ ℂ⸃ߩࡐࠗࡦ࠻ 3 ⁜ᔃᕈߢߪߤߩࠃ߁ߥᴦ≮ߣ⋴⼔ࠍߔࠇ߫ࠃ
޿ߢߔ߆㧫 㧙ᴦ≮ߣ੍ᓟ㧙 ౝ⑼⊛ᴦ≮㧦ᐔጊ◊ᔒ✬㧚2006 ᐕࡂ࡯࠻࠽࡯ࠪࡦࠣ⑺ᦼჇೀ Q&A ࠃࠅߪߓ߼ࠃ߁㧍 ౰േ⣂ࡑࠬ࠲࡯ࡉ࠶ࠢ㧘ᄢ㒋㧦ࡔ࠺ࠖࠞ಴ 㧧2006 ᐕ㧦44㧙57㧚
5㧕 ┻᧛రਃ㧘Ḋญା਽㧘⮮ේਭ⟵㧚15. G-CSF ⯯ⴊ∔ᖚ㧦᧻ᧄ㇌ᄦ㧘↰⇌ᵏᒾ✬㧚IV. ⚦⢩Ⴧᱺ࿃ሶߩฦ⺰⚦⢩Ⴧᱺ࿃ሶߣౣ↢ක≮㧘ᄢ㒋㧦ࡔ࠺ࠖࠞ࡞࡟ࡆࡘ࡯␠㧧2006 ᐕ㧦374㧙379㧚
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7㧕 ┻᧛రਃ㧘⮮ේਭ⟵㧚‫ޟ‬⢈ᄢဳᔃ╭∝ࡂࡦ࠼ࡉ࠶ࠢ –Life-long disease ߣߒߡߩࡑࡀࠫࡔࡦ࠻-‫ޠ‬7 ┨ ੍ᓟ࡮⥄ὼᱧ 5㧦੹ᴰീ⋙ୃ㧘ฎ⾐⟵ೣ✬㧚ᔃ╭࡝ࡕ࠺࡝ࡦࠣߩࡔࠞ࠾࠭ࡓ㧘᧲੩㧦ᣣᧄක੐ᣂႎ␠㧧2007
ᐕ㧦224㧙232㧚
8㧕 ┻᧛రਃ㧘⮮ේਭ⟵㧚‫ޡ‬ᔃ╭∝‫ޢ‬㧦᧻᫪ᤘ✬㧚[ᣂ⋡ߢߺࠆᓴⅣེ∛ࠪ࡝࡯࠭Ԧ] VIII. ᔃ╭∝⸻ᢿߩㅴᱠ㧦ᔃ╭∝ߩౣ↢ᴦ≮㧘᧲੩㧦ࡔࠫࠞ࡞ࡆࡘ࡯␠㧧2007 ᐕ㧦331㧙336㧚
9㧕 ┻᧛రਃ㧘⮮ේਭ⟵㧚╙ 1 ┨ ᕆᕈ౰∝୥⟲ߩᚑ࿃㧦∛ℂߣ∛ᘒ↢ℂ㧦㜞㊁ᾖᄦ✬㧚ᦨᣂකቇ೎ౠ‫ޟ‬ᣂߒ޿⸻ᢿߣᴦ≮ߩ ABC ╙ 48 Ꮞ ᕆᕈ౰∝୥⟲‫ޠ‬㧘ᄢ㒋㧦ᦨᣂකቇ␠㧧2007 ᐕ㧦15㧙21.
10㧕 ┻᧛రਃ㧘Ḋญା਽㧚‫ޟ‬ౣ↢ක≮ߩ⃻⁁ࠍ⼂ࠆ‫[ ޠ‬ᴦߔ] 13㧚G-CSF ࠍ↪޿ߚⴊ▤ౣ↢≮ᴺ㧦᧲੩㧦Heart
View㧦2007 ᐕ㧦97㧙104㧚
11㧕 Ꮉፒ㓷ⷙ㧚Integrated Backscatter Intravascular Ultrasound㧦IVUS ࡂࡦ࠼ࡉ࠶ࠢ㧘᧲੩㧦ਛጊᦠᐫ㧧
2006 ᐕ㧦282㧙289㧚
12㧕 Ꮉፒ㓷ⷙ㧚Integrated Backscatter Intravascular Ultrasound (IB-IVUS)㧦Coronary Intervention 2 Ꮞ
No.1㧘᧲੩㧦ࡔ࠺ࠖࠕ࡞ࡈࠔ㧧2006 ᐕ㧦96㧙102㧚
13㧕 Ꮉፒ㓷ⷙ㧚Integrated Backscatter Intravascular Ultrasound (IB-IVUS)㧦Heart View 10 Ꮞ No.3㧘᧲੩㧦ࡔࠫࠞ࡞ࡆࡘ࡯␠㧧2006 ᐕ㧦68㧙73㧚
14㧕 Ꮉፒ㓷ⷙ㧚ᓴⅣེ㗔ၞߦ߅ߌࠆᦨㄭߩක≮ᯏེ㧙౰േ⣂ࠗࡔ࡯ࠫࡦࠣⵝ⟎㧦ቇળᣂႎ 27 Ꮞ㧘No.1㧘᧲੩㧦ද᦭␠㧧2006 ᐕ㧦5㧙9㧚
15㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚╙Υㇱ㧦ᔃ∔ᖚෂ㒾࿃ሶߩᴦ≮ 5㧚༛ᾍ㧦ᄤ㊁ᕺሶ㧘ጊญᔀ✬㧚ᕈᏅ߆ࠄߺߚᅚᕈ
ߩᓴⅣེ∔ᖚ㧘᧲੩㧦ࡔࠫࠞ࡞ࡆࡘ࡯␠㧧2006 ᐕ㧦148㧙154㧚
16㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚Υ⸻ᢿߣᴦ≮ A.⯯ⴊᕈᔃ∔ᖚ 4㧚ᓴⅣེ∔ᖚߦ߅ߌࠆ༛ᾍߩ࡝ࠬࠢߣኻ╷㧦⍫ፒ⟵㓶㧘ጊญᔀ㧘㜞ᧄ⋿৻㧘ਛỈ⺈✬㧚Annual Review ᓴⅣེ㧘᧲੩㧦ਛᄖකቇ␠㧧2006 ᐕ㧦141㧙147㧚
17㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚15㧕༛ᾍ㧦ઍ↰ᶈਯ✬㧚౰േ⣂∔ᖚࡊࡠࡈࠚ࠶࡚ࠪࡦ 5 ౰േ⣂∔ᖚߩ੍㒐ᚢ⇛୘‫ޘ‬ߩෂ㒾࿃ሶߩ∉ቇ㧘⹏ଔᴺ㧘ᴦ≮ᴺߣߘߩࠛࡆ࠺ࡦࠬ㧘᧲੩㧦ਛጊᦠᐫ㧧2006 ᐕ㧦70㧙73㧚
18㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚Τേ⣂⎬ൻߩ੍㒐ߣᴦ≮ Step1 ෂ㒾࿃ሶߦኻߔࠆᴦ≮ D ࠲ࡃࠦࠍ߿߼ߐߖߚ޿
ߣ߈㧦ᢧ⮮ᐽᔒ㧘ጊ↰ାඳ✬㧚േ⣂⎬ൻ⸻≮ࡑ࠾ࡘࠕ࡞㧘᧲੩㧦ධᳯၴ㧧2006 ᐕ㧦132㧙136㧚
19㧕 ⮮ේਭ⟵㧘㘵↰⌀⟤㧘ਭᧁጊᷡ⾆㧘ᦳ໪ੑ㇢㧘㈕ᔘ๺㧚PASSPORT TO STOP SMOKING ╙ 2 㧘੩ㇺ㧦㧔␠㧕ᣣᧄᓴⅣེቇળ/ᣣᧄᓴⅣེቇળ⑌ᾍផㅴᆔຬળ㧧2006 ᐕ㧚
20㧕 㘵↰⌀⟤㧚ᣣᧄᓴⅣེቇળ㧘ᣣᧄ≸ቇળ㧘ᣣᧄ⢖≸ቇળ㧘╙ 3 ᰴኻ߇ࠎኻ╷✚วᚢ⇛⎇ⓥ⃰⑌ᾍᴦ≮ᮡḰᚻ㗅ᦠ૞ᚑࠣ࡞࡯ࡊ✬㧚⑌ᾍᴦ≮ߩߚ߼ߩᮡḰᚻ㗅ᦠ㧧2006 ᐕ㧚
21㧕 㘵↰⌀⟤㧚1.㕖⮎‛≮ᴺߦࠃࠆ੍㒐ߣ▤ℂ 2㧕⑌ᾍᵴേ‫ޡ‬ᔃਇోࠍ੍㒐ߔࠆ ⊒∝ߐߖߥ޿ ౣ⊒ߐߖߥ޿ߚ߼ߩ⸻≮ࠬ࠻࡜࠹ࠫ࡯‫ޢ‬㧦Φ.੍㒐ߣ▤ℂߩታ㓙㧘᧲੩㧦ਛጊᦠᐫ㧧2006 ᐕ㧦143㧙148㧚
22㧕 ⷏၂๺ᒾ㧚гᔃ╭∝ࠍ⼂ࠆ࡮⸻ࠆ࡮ᴦߔг㧦⏷ㇱశ┨㧘᧻ፒ⋉ᓼ✬㧚X㧚ᔃ╭∝ߩ㕖⮎‛ᴦ≮ߪߎߎ߹ߢㅴ

㧙㧙ᱠߒߚ 1㧚ᔃ⤳⒖ᬀߩㆡᔕߣ⃻ᴫ гᔃ⒖ᬀᖚ⠪ߩ⊓㍳ߩㅴ߼ᣇгᣂ࡮ᔃ⤳∛⸻≮ࡊ࡜ࠢ࠹ࠖࠬ 10.㧘᧲੩㧦ᢥశၴ㧧2007 ᐕ㧦356㧙358.
23㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚IV. ⯯ⴊᕈᔃ∔ᖚ ᄢⷙᮨ⹜㛎 ⁜ᔃ∝ ‫ޡ‬JSAP Study‫ޢ‬㧘ᣣᧄ⥃ῼ ‫ޡ‬ᄢⷙᮨ⥃ᐥ⹜㛎 㧙ᓴⅣ࡮ઍ⻢♽ࠍਛᔃߦ㧙‫ޢ‬2008 ᐕ㧦68(Ⴧೀภ)㧦357㧙362㧚⪺ᦠ㧔᰷ᢥ㧕
1㧕 Takemura G, Fujiwara H. Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to
management. Prog Cardiovasc Dis. 2007;49:330-352.
✚⺑㧔๺ᢥ㧕
1㧕 ⷏၂๺ᒾ㧚․㓸‫߇ࠊޡ‬࿖ߩ౰േ⣂∔ᖚߩ⥃ᐥࠛࡆ࠺ࡦࠬ‫ޢ‬1㧚ࠊ߇࿖ߩ౰േ⣂∔ᖚߩ∉ቇ㧘Vascular Biology& Medicine 㧙ⴊ▤කቇ㧙 2006 ᐕ㧧33 Ꮞ㧦11㧙16㧚
2㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚․㓸‫ޡ‬ᔃ╭᪪Ⴇߣ⣖᪪ႧߩኻᲧ гupdateг‫ ⺑⸃ޢ‬3㧚ᣣᧄੱߣ᰷☨ੱߩࠛࡆ࠺ࡦࠬ㧦㘃ૃὐߣ⋧㆑ὐ The evidence of the Japanese and the Westerner: The similarity and the difference. ᓴ
Ⅳ⑼ 2006 ᐕ㧧59 Ꮞ㧦503㧙509㧚
3㧕 ⷏၂๺ᒾ㧚Lecture ‫ޡ‬ᢛᒻᄖ⑼߇⺋ࠅ߿ߔ޿๟ⴚᦼ▤ℂߣ⢖Ⴇᩖ∝‫ޢ‬㧘⥃ᐥᢛᒻᄖ⑼ 2006 ᐕ㧧41 Ꮞ㧦1071
㧙1081㧚
4㧕 ⷏၂๺ᒾ㧚Sarpogrelate, a 5-HT2 receptor blocker, have an ischemic preconditioning-like effect.㧘
Angiology Frontier 2006 ᐕ㧧5 Ꮞ㧦74㧙78㧚
5㧕 ⷏၂๺ᒾ㧚Editorial Comment‫ޡ‬Ἳ∝ᕈ∔ᖚߣߒߡߩᕆᕈ౰∝୥⟲ hsCRP ߦࠃࠆ࡝ࠬࠢጀ೎ൻ‫ޢ‬㧘Japanese
Journal of Cardiovascular Catheter Therapeutics 2006 ᐕ㧧6 Ꮞ㧦344㧙345㧚
6㧕 ┻᧛రਃ㧚․㓸㧛ᘟᕈᔃਇోߩಽሶᯏ᭴㧦ᣂߒ޿ᴦ≮ᚢ⇛ࠍ᳞߼ߡ‫ߣࠬࠪ࡯࠻ࡐࠕޟ‬ᔃਇో‫ޠ‬㧘ᓴⅣེ⑼
2006 ᐕ㧧59 Ꮞ㧦547㧙554㧚
7㧕 ┻᧛రਃ㧘Ḋญା਽㧘⮮ේਭ⟵㧚․㓸㧛ᔃ⤳ⴊ▤♽ߩౣ↢කቇ㧦ᦨㄭߩㅴᱠߣ੹ᓟߩേะ‫ޟ‬ᔃ╭᪪Ⴇᴦ≮ߦ߅ߌࠆ G-CSF㧙᪪ႧᎽߦኻߔࠆ૞↪‫ޠ‬㧘ᓴⅣེ⑼ 2006 ᐕ㧧60 Ꮞ㧦33㧙38㧚
8㧕 ┻᧛రਃ㧘Ḋญା਽㧘⮮ේਭ⟵㧚․㓸‫▤ⴊޟ‬ᣂ↢ Update‫▤ⴊޠ‬ᣂ↢࿃ሶ G-CSF㧘⣂▤ቇ 2006 ᐕ㧧46
Ꮞ㧦317㧙325㧚
9㧕 ┻᧛రਃ㧚ᔃਇో UPDATE ᔃਇో⊒∝ߩࡔࠞ࠾࠭ࡓ ᔃਇోߣࠕࡐ࠻࡯ࠪࠬ㧙ᦨㄭߩㅴᱠ㧘කቇߩ޽ࠁ
ߺ 2006 ᐕ㧧218 Ꮞ㧦1117㧙1123㧚
10㧕 ┻᧛రਃ㧚ᔃ╭↢ᬌߩ੹ᣣ⊛ᗧ⟵㧘කቇߩ޽ࠁߺ 2006 ᐕ㧧219 Ꮞ㧦486㧙487㧚
11㧕 ┻᧛రਃ㧘⮮ේਭ⟵㧚․㓸‫ޟ‬ᔃਇోᴦ≮㧙Controversy 2006㧙‫ޠ‬VI. ౣ↢ක≮㧙⚦⢩߆㧫ࠨࠗ࠻ࠞࠗࡦ߆㧫㧙 (2) ࠨࠗ࠻ࠞࠗࡦ㧘Cardiovascular Med-Surg 2006 ᐕ㧧8 Ꮞ㧦59㧙67㧚
12㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚࡜ࠗࡈࠬ࠲ࠗ࡞࠼࡜࠶ࠣ߆ࠄᴦ≮⮎߳ߩዷ㐿 ‫ޟ‬༛ᾍ∛ߩᴦ≮㧙⑌ᾍࠟࠗ࠼࡜ࠗࡦ
ߦ߅ߌࠆ⮎‛≮ᴺࠍਛᔃߦ㧙‫ޠ‬㧘⮎ዪ 2006 ᐕ㧧57 Ꮞ㧦98㧙104㧚
13㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚༛ᾍߩஜᐽᓇ㗀ߣ‫⑌ޟ‬ᾍࠟࠗ࠼࡜ࠗࡦ‫ޠ‬㧘ో⮎ࠫࡖ࡯࠽࡞ 2006 ᐕ㧧224 ภ㧦12㧙
15㧚
14㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚࠲ࡃࠦߩኂ࡯޽ߥߚ߽ᱛ߼ࠄࠇࠆ ‫⑌ޟ‬ᾍࠟࠗ࠼࡜ࠗࡦ࡯ࡊ࡜ࠗࡑ࡝ࠤࠕකߩ૶޿
ᣇ‫ޠ‬㧘ࠢ࡝࠾ࠞ࡞ࡊ࡜ࠢ࠹ࠖࠬ 2006 ᐕ㧧25 Ꮞ㧦734㧙738㧚
15㧕 㘵↰⌀⟤㧘⮮ේਭ⟵㧚⑌ᾍࠟࠗ࠼࡜ࠗࡦߩࡐࠗࡦ࠻ ㅪタ‫ޡ‬ᓴⅣེ∔ᖚߩ⹤㗴 TOPIC‫ޢ‬㧘ࡂ࡯࠻࠽࡯ࠪࡦ
ࠣ 19 2006 ᐕ.
16㧕 㘵↰⌀⟤㧚࠾ࠦ࠴ࡦଐሽ∝▤ℂᢱгᧄ▤ℂᢱߩో૕௝ࠍߣࠄ߃ࠆг‫⑌ޟ‬ᾍᴦ≮ߩߚ߼ߩᮡḰᚻ㗅ᦠ‫ޠ‬㧘ᴦ≮
2006 ᐕ㧧88 Ꮞ㧦2475㧙2480㧚
17㧕 ⮮ේਭ⟵㧘┻᧛రਃ㧚ᣣᧄ⥃ᐥჇೀภ ᔃਇో㧔਄㧕㧦̅ᦨㄭߩၮ␆࡮⥃ᐥ⎇ⓥߩㅴᱠ̅ ᔃਇోၮ␆⎇ⓥߩ
ㅴᱠߣ੹ᓟߩ⺖㗴㧘㧧ᣣᧄ⥃ᐥ㧧2007㧦65(Suppl 4)㧦9㧙16㧚
18㧕 ┻᧛రਃ㧚ᣣᧄ⥃ᐥჇೀภ ᔃਇో㧔਄㧕:̅ᦨㄭߩၮ␆࡮⥃ᐥ⎇ⓥߩㅴᱠ̅ ᔃ╭⚦⢩ߩࠕࡐ࠻࡯ࠪࠬߣࠝ
࡯࠻ࡈࠔࠫ࡯㧘᧲੩㧦ᣣᧄ⥃ᐥ㧧2007 ᐕ㧦65(Suppl 4)㧦143㧙148㧚
19㧕 ┻᧛రਃ㧚ᔃ╭ࠕࡐ࠻࡯ࠪࠬ㧦๭ๆߣᓴⅣ; 2007 ᐕ㧦55㧦429㧙440㧚
20㧕 ┻᧛రਃ㧚‫ޡ‬ᣣᧄ⥃ᐥ‫ޢ‬
㧦2007 ᐕ೎ౠ ᓴⅣེ∝୥⟲(╙ 2 ) (I) ̅ߘߩઁߩᓴⅣེ∔ᖚࠍ฽߼ߡ࡯: II ᔃਇో㧦᪪Ⴇᓟᔃਇో㧚ᄢ㒋㧦ᣣᧄ⥃ᐥ␠㧧2007 ᐕ㧦168㧙172㧚
21㧕 ┻᧛రਃ㧘Ḋญା਽㧚‫ޟ‬ౣ↢ක≮ߩ⃻⁁ࠍ⼂ࠆ‫[ ޠ‬ᴦߔ] 13㧚G-CSF ࠍ↪޿ߚⴊ▤ౣ↢≮ᴺ㧦᧲੩㧦Heart
View; 2007 ᐕ㧦97㧙104㧚 
22㧕 ┻᧛రਃ㧚․㓸㧦ᘟᕈᔃਇో⮎‛ᴦ≮ߩ⃻⁁ߣ੹ᓟߩዷᦸ 12. ⽺ⴊᴦ≮࡮ࠨࠗ࠻ࠞࠗࡦ≮ᴺ㧦ᓴⅣེ⑼㧘
᧲੩㧦⑼ቇ⹏⺰␠㧧2007 ᐕ㧦473㧙481㧚
23㧕 ⷏၂๺ᒾ㧚╙ 71 ࿁ᣣᧄᓴⅣེቇળቇⴚ㓸ળ ᓴⅣེᢎ⢒࠮࠶࡚ࠪࡦ III ACS ߩ࡝ࠬࠢጀ೎ൻߣᴦ≮ᚢ⇛
–PCI ߣ CABG ࠍਛᔃߦ-㧦‫ࠢࠬ࡝ߗߥޡ‬ጀ೎ൻ߇ᔅⷐ߆㧫 ̆࡝ࠬࠢጀ೎ൻߩᔅⷐᕈߣታ㓙̆‫ޢ‬㧘᧲੩㧦ᓴ
Ⅳེኾ㐷ක㧧2007 ᐕ㧦70㧙79㧚
24㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚╙ 8 ࿁㊀∝ᔃਇోᴦ≮ࡈࠜ࡯࡜ࡓ ࠪࡦࡐࠫ࠙ࡓ ‫ޡ‬ᔃ⤳⒖ᬀߩⴚ೨ⴚᓟߣ㐳ᦼ▤ℂ‫ޢ‬㧦ࠊ߇࿖ߦ߅ߌࠆᔃ⤳⒖ᬀߩ⃻⁁ߣ໧㗴ὐ㧘᧲੩㧦๭ๆߣᓴⅣ㧧2007 ᐕ㧦S9㧙S17㧚
25㧕 ⷏၂๺ᒾ㧚ࠊ߇࿖ߪାߓ߇ߚ޿ᔃ⤳⒖ᬀ“ᓟㅴ࿖”㧘KNG ጘ㒂⋵ᔃ⤳∛ఽ⠪ߩળ㧔․㓸ภ㧕2008㧧332 Ꮞ㧦
4㧙5㧚
26㧕 ⷏၂๺ᒾ㧘⮮ේਭ⟵㧚⹤㗴ߩ⺰ᢥ‫ޡ‬COURAGE Trial: ቟ቯ౰േ⣂∔ᖚᖚ⠪ߦኻߔࠆೋᦼᴦ≮ߣߒߡ⥋ㆡ⮎‛ᴦ≮ߦ⚻⊹⊛౰േ⣂ࠗࡦ࠲࡯ࡌࡦ࡚ࠪࡦ㧔PCI㧕ࠍㅊടߒߡ߽ᱫ੢߅ࠃ߮ᔃ╭᪪Ⴇߩ࡝ࠬࠢࠍᛥ೙ߔࠆ
ലᨐߪߥ޿‫ޢ‬㧘ⴊᩖߣᓴⅣ 2008㧧16 Ꮞ㧦85㧙87㧚㧙㧙

27㧕 ⷏၂๺ᒾ㧘ጊፒ ജ㧚Japanese Coronary Artery Disease (JCAD)⎇ⓥߦ߅ߌࠆ⎣㉄⮎ߩᔃⴊ▤♽ࠗࡌࡦ࠻߳ߩᓇ㗀ߦߟ޿ߡ㧘Medicament News 2008 ᐕ㧧1953 ภ㧦29㧚✚⺑㧔᰷ᢥ㧕
1㧕 Takemura G, Fujiwara H. Morphological aspects of apoptosis in heart diseases. J Cell Mol Med.
2006;10:5-75.
ේ⪺㧔๺ᢥ㧕
1㧕 Ḋญା਽㧚ࠨࠗ࠻ࠞࠗࡦߦࠃࠆᔃⴊ▤ౣ↢≮ᴺ㧘േᘒᩭකቇ 2006 ᐕ㧧23 Ꮞ㧦11㧙16㧚
2㧕 ┻᧛రਃ㧘Ḋญା਽㧘⮮ේਭ⟵㧚ⴊ▤ᣂ↢࿃ሶ G-CSF㧘⣂▤ቇ 2006 ᐕ㧧46 Ꮞ㧦317㧙325㧚
3㧕 ⮮ේਭ⟵㧘⷏၂๺ᒾ㧚․㓸‫ߗߥޡ‬ౝ⑼කߪ⒖ᬀක≮ߦ߆߆ࠊࠄߥ޿߆㧫‫ޢ‬ᔃ⤳⒖ᬀߩ┙႐߆ࠄ 㧙ᚒ߇࿖ߪାߓ߇ߚ޿ᔃ⤳⒖ᬀᓟㅴ࿖㧙㧘ᣣᧄ⒖ᬀቇળ㔀⹹ ⒖ᬀ 2006 ᐕ㧧41 Ꮞ㧦2㧙9㧚
4㧕 ጟ↰⧷ᔒ㧘ዊႮା੺㧘ጤ૒዁ల㧘Ꮉ᧛৻ᄥ㧘ዊୖ⌀ᴦ㧘቟↰⌀ᥓ㧘ᦡ⻞ᰴ㧘᫪㤀㧘⷏၂๺ᒾ㧘┻᧛రਃ㧘Ḋญା਽㧘⮮ේਭ⟵㧘㜞ᧁᐘᶈ㧚කᏧหਸ਼ߦࠃࠆጘ㒂ဳᢇᕆࡋ࡝ߦࠃࠆㄦㅦߥ៝ㅍߦࠃߞߡᢇ๮ߒ߃ߚᕆ
ᕈᔃ╭᪪Ⴇߩ৻଀㧘ጘ㒂⋵කᏧળකቇ㔀⹹ 2007 ᐕ㧧20 Ꮞ㧦47㧙51㧚
5㧕 ዊᨋᶈਯ㧘Ḋญା਽㧘൮࠽࡟ࡦ࠻ࡗ㧘቟↰⌀ᥓ㧘ᠲ⵨㧘ዊ㊁ᧁᶈੱ㧘‐⿧ඳᤘ㧘⨹੗ᱜ⚐㧘ጤ૒዁ల㧘㣐⷗዁ᐔ㧘┻᧛రਃ㧘⮮ේਭ⟵㧘↰⇌ᵏᒾ㧘⮮ේహሶ㧚ࠛ࡝ࠬࡠࡐࠗࠛ࠴ࡦ⮎‛ᓢ᡼ࠪࠬ࠹ࡓ(Drug Delivery
System)ߩᔃ╭᪪Ⴇࠨࠗ࠭❗ዊ߅ࠃ߮࡝ࡕ࠺࡝ࡦࠣᛥ೙ലᨐ㧘ጘ㒂⋵ౝ⑼කળ㔀⹹ 2007 ᐕ㧧21 Ꮞ㧦23㧙
24㧚
6㧕 ↰ਛᣂ৻㇢㧘Ḋญା਽㧘⊝Ꮉᄥ㇢㧘⷏၂๺ᒾ㧘Ꮉ᧛৻ᄥ㧘㣐⷗዁ᐔ㧘ᮮጊߜߪࠆ㧘ศ⋿ ቁ㧘㆙ᷰ⚐ノ㧘┻ጊବᤘ㧘ฬ๺㓉⧷㧘ዊႮା੺㧘Ꮉፒ㓷ⷙ㧘┻᧛రਃ㧘⮮ේਭ⟵㧚ST ਄᣹ဳᕆᕈᔃ╭᪪Ⴇౣἠᵹᓟߩᣧᦼ
ㆇേ≮ᴺ੺౉߇ᏀቶኈⓍߦਈ߃ࠆᓇ㗀ߩᬌ⸛—ࠬ࠹ࡦ࠻ᤨઍߩᣧᦼㆇേ≮ᴺ—㧘ᔃ⤳࡝ࡂࡆ࡝࠹࡯࡚ࠪࡦ㧔JJCR㧕2008 ᐕ㧧13 Ꮞ㧦189㧙194㧚
7㧕 ⷏၂๺ᒾ㧚Challenge QUIZ ⾆ᣇ߽ฬක‫ ଀∝ޡ‬27 ᱦ⊕ੱᅚᕈࡉ࡜ࠫ࡞಴り ਥ⸷:ᄬ␹⊒૞‫ޢ‬㧘CLINIC
magazine 2008 ᐕ㧧467 Ꮞ㧦72㧙73㧚
8㧕 ⷏၂๺ᒾ㧚․㓸‫ޡ‬ᓴⅣེ♽∔ᖚߩ࠻ࡇ࠶ࠢࠬ‫ޢ‬㧘౰ᡨ❗ᕈ⁜ᔃ∝ߩᦨᣂ⮎‛≮ᴺ Medicament News 2008ᐕ㧧1964 ภ㧦5㧙7.
ේ⪺㧔᰷ᢥ㧕
1㧕 Hirano T, Tsuchiya K, Nishigaki K, Sou K, Kubota T, Ojio S, Kawasaki M, Minatoguchi S, Fujiwara H,
Ueno K, Hosokawa H, Morita N, Nagano T, Suzuki T, Watanabe S. Clinical features of emergency
electrocardiography in patients with acute myocardial infarction caused by left main trunk
obstruction. Circ J. 2006;70:525-529.
2㧕 Miyata S, Takemura G, Kawase Y, Li Y, Okada H, Maruyama R, Ushikoshi H, Esaki M, Kanamori H,
Li L, Misao Y, Tezuka A, Toyo-Oka T, Minatoguchi S, Fujiwara T, Fujiwara H. Autophagiccardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocytecolony-stimulating factor. Am J Pathol. 2006;168:386-397.
3㧕 Misao Y, Takemura G, Arai M, Sato S, Suzuki K, Miyata S, Kosai K, Minatoguchi S, Fujiwara T,
Fujiwara H. Bone marrow-derived myocyte like cells and regulation of repair-related cytokines after
bone marrow cell transplantation. Cardiovasc Res. 2006;69:476-490.
4㧕 Sano K, Kawasaki M, Ishihara Y, Okubo M, Tsuchiya K, Nishigaki K, Zhou X, Minatoguchi S, Fujita H,
Fujiwara H. Assessment of vulnerable plaques causing acute coronary syndrome using integrated
backscatter intravascular ultrasound. J Am Coll Cardiol. 2006;47:734-741.
5㧕 Li Y, Takemura G, Okada H, Miyata S, Esaki M, Maruyama R, Kanamori H,Li L, Ogino A, Misao Y,
Khai NC, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. Treatment with granulocytecolony-stimulating factor ameliorates chronic heart failure. Lab Invest. 2006;86:32-44.
6㧕 Suzuki K, Nagashima K, Arai M, Uno Y, Misao U, Takemura G, Nishigaki K, Minatoguchi S, Watanabe
S, Tei C, Fujiwara H. Effect of granulocyte colony-stimulating factor treatment at a low dose but for along duration in patients with coronary heart disease –a pilot study-. Circ J. 2006;70:430-437.
7㧕 Tanihata S, Nishigaki K, Kawasaki M, Takemura G, Minatoguchi S, Fujiwara H. Outcomes of patientswith stable low –risk coronary artery disease receiving medical- and PCI- preceding therapies I Japan– J-SAP Study 1-1-. Circ J. 2006;70:365-369.
8㧕 Takahashi M, Minatoguchi S, Nishigaki K, Kawasaki M, Arai M, Uno Y, Fujiwara H. Long-term andstrict blood pressure lowering by imidapril reverses left ventricular hypertrophy in patients withessential hypertension: an evaluation using a novel indicator of burden on the left ventricle.
Hypertens Res. 2006;29:89-94.
9㧕 Li L, Takemura G, Li Yien, Miyata S, Esaki M, Okada H, Kanamori H, Khai NC, Maruyama R, Ogino
A, Minatoguchi S, Fujiwara T, Fuijiwara H. Preventive effect of erythropoietin on cardiac dysfunction
in doxorubicin-induced cardiomyopathy. Circulation. 2006;113:535-543.
10㧕 Onogi H, Minatoguchi S, Chen XH, Bao N, Kobayashi H, Misao Y, Yasuda S, Yamaki T, Maruyama R,
Masazumi A, Takemura G, Fujiwara H. Edaravone reduces the myocardial infarct size and improves
cardiac function and remodeling in Rabbits. Clin Exp Pharmacol Physiolol. 2006;33:1035-1041.
11㧕 Maruyama R, Takemura G, Tohse N, Ohkusa T, Ikeda Y, Tsuchiya K, Minatoguchi S, Matsuzaki M,㧙㧙IF 2.135

IF 0.333

IF 5.826

IF 9.701

IF 4.453

IF 2.135

IF 2.135

IF 3.177

IF 10.940

IF 1.780

FujiwaraT, Fujiwara H. Synchronous progression of calcium transient-dependent beating andsarcomere destruction inapoptotic adult cardiomyocytes. Am J Physiol Heart Circ Physiol.
2006;290:H1493-H1502.
IF
12㧕 Tadokoro M, Osumi Y, Minatoguchi S, Kariya T, Yokoyama H, Araki H, Sawada S, Ohashi S,
Watanabe S, Ito H, Fujiwara H. Plasma BNP level in chronic hemodialysis patients: a good indicator ofleft ventricular diastolic dysfunction. Dialysis&Transplantation. 2006;35:10-14.
IF13㧕 Koda M, Takemura G, Okada H, Kanoh M, Maruyama R, Esaki M, Li Y, Miyata S, Kanamori H, Li L,
Ogino A, Kondo T, Minatoguchi S, Fujiwara T, Fujiwara H. Nuclear hypertrophy reflects increased
biosynthetic activities in myocytes of human hypertrophic hearts. Circ J. 2006;70:710-718.
IF
14㧕 Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H.
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair
mediated by G-CSF. Cardiovasc Res. 2006;71:455-465.
IF
15㧕 Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Li L, Higuchi M, Minatoguchib S, Fujiwara T,
Fujiwara H. Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin
in chronic heart failure. Cardiovasc Res. 2006;71:684-694.
IF
16㧕 Fukunishi M, Nishigaki K, Okubo M, Kawasaki M, Takemura G, Minatoguchi S, Fujiwara H. J-SAP
Study 1-2: Outcome of patients with stable high-risk coronary artery disease receiving
medical-preceding therapy in Japan. Circ J. 2006;70:1012-1016.
IF
17㧕 Arai M, Misao Y, Nagai H, Kawasaki M, Nagashima K, Suzuki K, Tsuchiya K, Otsuka S, Uno Y,
Takemura G, Nishigaki K, Minatoguchi S, Fujiwara H. Granulocyte colony-stimulating Factor – anoninvasive regeneration therapy for treating atherosclerotic peripheral artery disease. Circ J.
2006;70:1093-1098.
IF
18㧕 Lu C, Minatoguchi S, Arai M, Wang N, MD; Chen X, Bao N, Kawamura I, Yasuda S, Kobayashi H, Wu
D, Takemura G, Fujiwara H. Nicorandil improves post-ischemic myocardial dysfunction in association
with opening the mitochondrial KATP channels and decreasing hydroxyl radicals in isolated rat hearts.
Circ J. 2006;70:1650-1654.
IF
19㧕 Yuhgetsu H, Ohno Y, Funaguchi N, Asai T, Sawada M, Takemura G, Minatoguchi S, Fujiwara T,
Fujiwara H. Beneficial effects of autologous bone marrow mononuclear cell transplantation via thetrachea against elastase-induced emphysema in rabbits. Exp Lung Res. 2006;32:413-426.
IF
20㧕 Tsujimoto A, Takemura G, Mikami A, Aoyama T, Ohno T, Maruyama R, Nakagawa M, Minatoguchi S,
Fujiwara H. A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced
apoptosis in human vascular smooth muscle cells. J Cardiovasc Pharmacol. 2006;48:160-165.
IF
21㧕 Kagawa T, Takemura G, Kosai K, Murata I, Ohno T, Takahashi T, Esaki M, Maruyama R, Fujiwara T,
Ohashi H, Fujiwara H. Hepatocyte growth factor gene therapy slows down the progression of diabetic
nephropathy in db/db mice. Nephron Physiol. 2006;102:92-102.
IF
22㧕 Takemura G, Miyata S, Kawase Y, Okada H, Maruyama R, Fujiwara H. Autophagic degeneration anddeath of cardiomyocytes in heart failure. Autophagy. 2006;2:212-214.
23㧕 Lu C, Arai M, Misao Y, Chen X, Wang N, Onogi H, Kobayashi H, Uno Y, Takemura G, Minatoguchi S,
Fujiwara T, Fujiwara H. Autologous bone marrow cell transplantation improves left ventricularfunction in rabbit hearts with cardiomyopathy via myocardial regeneration-unrelated mechanisms.
Heart Vessels. 2006;21:180-187.
IF
24㧕 Takahashi T, Kawai T, Ushikoshi H, Nagano S, Oshika H, Inoue M, Kunisada T, Takemura G,
Fujiwara H, Kosai KI. Identification and isolation of embryonic stem cell-derived target cells by
adenoviral conditional targeting. Mol Ther. 2006;14:673-683.
IF
25㧕 Kawasaki M, Bouma BE, Bressner J, Houser SL, Nadkarni SK, MacNeill BD, Jang IK, Fujiwara H,
Tearney GJ. Diagnostic accuracy of optical coherence tomography and integrated backscatter
intravascular ultrasound images for tissue characterization of human coronary plaques. J Am Coll
Cardiol. 2006;48:81-88.
IF
26㧕 Khai NC, Takahashi T, Nagano S, Yuge K, Esaki M, Kawai T, Goto K, Murofushi Y, Fujiwara T,
Fujiwara H, Kosai KI. In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury
and induces liver regeneration in mice: A comparative study to HGF. J Hepatol. 2006;44:1046-1054.
IF
27㧕 Iida H, Iida M, Takenaka M, Fujiwara H, Dohi S. Angiotensin II type 1(AT1)-receptor blocker prevents
impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rat. Life Sci.
2006;78:1310-1316.
IF
28㧕 Iida H, Iida M, Ohata H, Michino T, Dohi S. Effects of dexmedetomidine on cerebral circulation andsystematic hemodynamics after cardiopulmonary resuscitation in dogs. J Anesth. 2006;20:202-207.
29㧕 Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Esaki M, Khai NC, Kanamori H, Li L, Ogino A,
Minatoguchi S, Fujiwara T, Fujiwara H.ANG II type 1A receptor signaling causes unfavorable scar
dynamics in the postinfarct heart.Am J Physiol. Heart Circ Physiol. 2007;292:H946-H953.
IF
30㧕 Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Esaki M, Kanamori H, Li L, Ogino A, Ohno T,
Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Molecular signaling mediated byangiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart
failure. J Card Fail. 2007;13:155-162.
IF

㧙㧙

3.724

0.248

2.135

5.826

5.826

2.135

2.135

2.135

1.427

1.625

1.462

1.056

5.841

9.701

6.073

2.389

3.724

2.737

31㧕 Miyajima K, Minatoguchi S, Ito Y, Fukunishi M, Matsuno Y, Kakami M, Kawasaki M, Nishigaki K,
Takemura G, Fujiwara H. The reduction of QTc dispersion by angiotensin II receptor blocker valsartan
may be related to its anti-oxidative stress effect in patients with essential hypertension. Hypertens
Res. 2007;30:307-313.
32㧕 Kanamori H, Takemura G, Li Y, Okada H, Maruyama R, Aoyama T, Miyata S, Esaki M, Ogino A,
Nakagawa M, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara H. Inhibition of Fas-associatedapoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricularremodeling by olmesartan. Am J Physiol Heart Circ Physiol. 2007;292:H2184-H2194.
33㧕 Chen XH, Minatoguchi S, Arai M, Wang N, Lu C, Bao N, Uno Y, Misao Y, Takemura G, Fujiwara T,
Fujiwara H. Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitricoxide in a rabbit model of myocardial infarction.Circ J. 2007;71:574-579.
34㧕 Asai T, Ohno Y, Minatoguchi S, Funaguchi N, Yuhgetsu H, Sawada M, Takemura G, Komada A,
Fujiwara T, Fujiwara H.The specific free radical scavenger edaravone suppresses bleomycin-induced
acute pulmonary injury in rabbits. Clin Exp Pharmacol Physiol. 2007;34:22-26.
35㧕 Misao Y, Arai M, Ohno T, Ushikoshi H, Onogi H, Kobayashi H, Takemura G, Minatoguchi S, Fujiwara
T, Fujiwara H. Modification of post-myocardial infarction granulocyte-colony stimulating factor
therapy with myelosuppressives. Circ J. 2007;71:580-590.
36㧕 Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Ogino A, Maruyama R, Nakagawa
M, Minatoguchi S, Fujiwara T, Fujiwara H. Granulocyte colony-stimulating factor improves left
ventricular function of doxorubicin-induced cardiomyopathy. Lab Invest. 2007;87:440-455.
37㧕 Funaguchi N, Ohno Y, La BL, Asai T, Yuhgetsu H, Sawada M, Takemura G, Minatoguchi S, Fujiwara T,
Fujiwara H. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol
Physiol. 2007;34:766-770.
38㧕 Sawada M, Ohno Y, La BL, Funaguchi N, Asai T, Yuhgetsu H, Takemura G, Minatoguchi S, Fujiwara
H, Fujiwara T. The fas/fas-ligand pathway does not mediate the apoptosis in elastase-induced
emphysema in mice. Exp Lung Res. 2007;33:277-288.
39㧕 Nakagawa M, Ohno T, Maruyama R, Okubo M, Nagatsu A, Inoue M, Tanabe H, Takemura G,
Minatoguchi S, Fujiwara H. Sesquiterpene lactone suppresses vascular smooth muscle cellproliferation and migration via inhibition of cell cycle progression. Biol Pharm Bull.
2007;30:1754-1757.
40㧕 Bao N, Minatoguchi S, Kobayashi H, Yasuda S, Kawamura I, Iwasa M, Yamaki T, Sumi S, Misao Y,
Arai M, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H. Pravastatin reduces myocardial infarct
size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opeing themitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Circ J.
2007;71:1622-1628.
41㧕 Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S, Esaki M, Nakagawa M,
Aoyama T, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara T, Fujiwara H. Amlodipine inhibits
granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction
cardiac remodeling. Am J Physiol Heart Circ Physiol. 2007;293:H2271-H2280.
42㧕 Io K, Minatoguchi S, Nishigaki K, Ojio S, Tanaka T, Segawa T, Matsuo H, Wtanabe S, Hattori A, Ueno
K, Ono H, Hiei K, Sato H, Morita N, Noda T, Kato T, Kawasaki M, Takemura G, Fujiwara H. Effects ofbenidipine and some other calcium channel blockers on the prognosis of patients with vasospastic
angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Arzneimittelforschung. 2007;57:573-581.
43㧕 Chen X-H, Minatoguchi S, Kosai K, Yuge K, Takahashi T, Arai M, Wang N, Misao Y, Lu C, Onogi H,
Kobayashi H, Yasuda S, Esaki M, Ushikoshi H, Takemura G, Fujiwara T, Fujiwara H. In vivo
hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its
multiple actions. J Card Fail. 2007;13:874-883.
44㧕 Okubo M, Masanori K, Ishihara Y, Takeyama U, Kubota T, Yamaki T, Ojio S, Nishigaki K, Takemura
G, Saio M, Takami T, Minatoguchi S, Fujiwara H. Development of integrated Backscatter
intravascular ultrasound for tissue characterization of coronary plaques. Ultrasound Med Biol
2008;34:655-663.
45㧕 Nishigaki K, Yamazaki T, Kitabatake A, Yamaguchi T, Kanmatsuse K, Kodama I, Takekoshi N,
Tomoike H, Hori M, Matsuzaki M, Takeshita A, Shimbo T, Fujiwara H, for the JSAP (Japanese Stable
Angina Pectoris) Study Investigators. Percutaneous coronary intervention plus medical therapy
reduces the incidence of acute coronary syndrome more effectively than initial medical therapy only
among patients with low-risk coronary artery disease: A randomized, comparative, multicenter study.
J Am Coll Cardiol: Cardiov Interv 2008;1:469-479.
46㧕 Tanaka S, K, Ojio S, Okubo M, Yasuda S, Ishihara Y, Kubota T, Takasugi N, Kawamura I, Yamaki T,
Ushikoshi H, Aoyama T, Kawasaki M, Takkemura G, Minatoguchi S. Can negative cardiac effect ofproton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stableangina? J Cardiol 2008;52:39-48.
47㧕 Okubo M , Kawasaki M, Ishihara Y, Takeyama U, Yasuda S, Kubota T, Tanaka S, Yamaki T, Ojio S,㧙㧙

IF 3.177

IF 3.724

IF 2.135

IF 1.780

IF 2.135

IF 4.453

IF 1.780

IF 1.427

IF 1.522

IF 2.135

IF 3.724

IF 0.596

IF 2.737

Nishigaki K, Takemura G, Saio M, Takami T, Fujiwara H, Minatoguchi S. Tissue characterization ofcoronary plaques -Comparison of integrated Backscatter intravascular ultrasound with virtual
histology intravascular ultrasound. Circ J 2008;72:1631-1639.
IF 2.13548㧕 Tanaka S, Yokoyama C, Kawamura I, Takasugi N, Kubota T, Ushikoshi H, Aoyama T, Kawasaki M,
Nishigaki K, Takemura G, Minatoguchi S. Conservative medication follow-up for over 20 years of apatient with ischemic heart disease after diagnosis of chronic total occlusion of the 3 main coronary
arteries. Circ J 2008;72:1205-1209.
IF 2.135
49㧕 Kobayashi H, Minatoguchi S, Yasuda S, Bao N, Kawamura I, Iwasa M, Yamaki T, Sumi S, Misao Y,
Ushikoshi H, Nishigaki K, Takemura G, Fujiwara T, Tabata Y, Fujiwara H. Post-infarct treatment
with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair. Cardiov Res
2008:79:611-620.
IF 5.82650㧕 Tanaka S, Nishigaki K, Ojio S, Yasuda S, Okubo M, Yamaki T, Kubota T, Takasugi N, Ishihara Y,
Kawasaki M, Minatoguchi S. Transcatheter embolization by autologous blood clot is usefulmanagement for small side branch perforation due to percutaneous coronary intervention guide wire.
J Cardiol. 2008;52:285-289.

4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦Ḋญା਽㧘⎇ⓥಽᜂ⠪㧦ߥߒ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚⎇ⓥ(C)(2)㧦⯯ⴊᕈᔃ∔ᖚߦኻߔࠆ㗰☸⃿ࠦࡠ࠾࡯ೝỗ࿃ሶ⊹ਅᵈ኿ߦࠃࠆૐଚⷅ≮ᴺߩ㐿⊒㧧ᐔᚑ 18㧙19 ᐕᐲ㧧3,890
ජ౞(2,200㧦1,690 ජ౞)
2㧕 ⎇ⓥઍ⴫⠪㧦Ꮉፒ㓷ⷙ㧘⎇ⓥಽᜂ⠪㧦ߥߒ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄⪚⧘⎇ⓥ㧦᳇▤ᡰญ⣧ౝ⿥㖸ᵄᢿጀᴺߦ߅ߌࠆᓟᣇᢔੂᵄߦࠃࠆ⚵❱ᕈ⁁⸻ᢿࡊࡠࠣ࡜ࡓߩ㐿⊒㧧ᐔᚑ 18㧙19 ᐕᐲ㧧3,100
ජ౞(1,500㧦1,600 ජ౞)
3㧕 ⎇ⓥઍ⴫⠪㧦⊕ୖ⦟ᄥ(ᄢ㒋ᄢቇ)㧘⎇ⓥಽᜂ⠪㧦⮮ේਭ⟵㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄ࡅ࠻ࠥࡁࡓ࡮
ౣ↢ක≮╬⎇ⓥ੐ᬺ㧦⒖ᬀක≮ߦ㑐ߔࠆ࿖㓙Ყセಽᨆߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 18 ᐕᐲ㧧2,000 ජ౞4㧕 ⎇ⓥઍ⴫⠪㧦෹ᳰੳᥰ(࿖┙ᓴⅣེ∛࠮ࡦ࠲࡯)㧘⎇ⓥಽᜂ⠪㧦╴੗ᶈਯ(ർᶏ㆏ᄢቇ)㧘ਭ଻↰᡹(ጊᒻᄢቇ)㧘᳗੗⦟ਃ(᧲੩ᄢቇ)㧘ዊᎹ⡡(ᘮᔕ⟵Ⴖᄢቇ)㧘๺ᴰᔀ(ർ㉿ᄢቇ)㧘⮮ේਭ⟵㧘᧻᫪ᤘ(੩ㇺᄢቇ)㧘
ਛ⼱ᱞ༹(࿖┙ᓴⅣེ∛࠮ࡦ࠲࡯)㧘ၳᱜੑ(ᄢ㒋ᄢቇ)㧘ᮮጊశብ(␹ᚭᄢቇ)㧘᧻㦮⋉ᓾ(ጊญᄢቇ)㧘⍾Ꮉ⾫ੑ(਻Ꮊᄢቇ)㧘੹ᴰീ(ਭ⇐☨ᄢቇ)㧘㈕ᔘ๺(㣮ఽፉᄢቇ)㧧ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㔍ᴦᕈ∔ᖚస᦯⎇ⓥ੐ᬺ㧦․⊒ᕈᔃ╭∝ߦ㑐ߔࠆ⺞ᩏ⎇ⓥ㧧ᐔᚑ 17㧙19 ᐕᐲ㧧2,500 ජ౞(1,500㧦1,000㧦ජ౞)
5㧕 ⎇ⓥઍ⴫⠪㧦╴੗ᶈਯ(ർᶏ㆏ᄢቇ)㧘⎇ⓥಽᜂ⠪㧦ጊญᔀ(⯥ߩ㐷∛㒮)㧘☨Ỉ৻਽(࿖┙∛㒮ᯏ᭴ವ㙚∛㒮)㧘ਅᎹብ᣿(᧲ർᄢቇ)㧘᳗੗⦟ਃ(᧲੩ᄢቇ)㧘๺ᴰᔀ(ർ㉿ᄢቇ)㧘ዊᎹ⡡(ᘮᔕ⟵Ⴖᄢቇ)㧘ᮮጊᐢⴕ(࿖┙∛㒮ᯏ᭴㕒ጟක≮࠮ࡦ࠲࡯)㧘⮮ේਭ⟵㧘෹ᳰੳᥰ(࿖┙ᓴⅣེ∛࠮ࡦ࠲࡯)㧘ၳᱜੑ(ᄢ㒋ᄢቇ)㧘ᮮጊశብ(␹ᚭᄢቇ)㧘⫌ጊ⒤(ᄢ㒋Ꮢ┙ᄢቇ)㧘᧻㦮⋉ᓾ(ጊญᄢቇ)㧘੹ᴰീ(ਭ⇐☨ᄢቇ)㧘᧻ᧄ㜞ብ(࿖┙∛㒮ᯏ᭴਻Ꮊක≮࠮ࡦ࠲࡯)㧘ጊፒജ(᧲੩ᄢቇ)㧘Ḵ਄ື਽(਻Ꮊᄢቇ)㧘ጯ⃍ሶ(ർᶏ㆏ᄢቇ)㧧
ෘ↢ഭ௛⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ᓴⅣེ∔ᖚ╬↢ᵴ⠌ᘠ∛ኻ╷✚ว⎇ⓥ੐ᬺ㧦ో࿖ᖚ⠪⊓㍳࠺࡯࠲ࠍ↪
޿ߚࠊ߇࿖ߩᘟᕈᔃਇోᖚ⠪ߩᕆᕈჇᖡ࡮㔍ᴦൻⷐ࿃ߩ⸃᣿ߣലᨐ⊛ᴦ≮ᴺߩ⏕┙㧧ᐔᚑ 17㧙19 ᐕᐲ㧧0 ජ౞(ਥછ⎇ⓥ⠪৻᜝⸘਄ߩߚ߼)6㧕 ⎇ⓥઍ⴫⠪㧦Ḋญା਽㧘⎇ⓥಽᜂ⠪㧦᧘㦖⯥㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄․೎⎇ⓥຬᅑബ⾌㧦ࠛ࡝ࠬࡠࡐࠛ࠴ࡦᓢ᡼ൻ࠼࡜࠶ࠣ࠺࡝ࡃ࡝࡯ࠪࠬ࠹ࡓߦࠃࠆ㐽Ⴇᕈേ⣂⎬ൻ∝ᴦ≮ᴺߩ㐿⊒㧧ᐔᚑ 19㧙20 ᐕᐲ㧧2,200 ජ౞(1,100㧦1,100 ජ౞)
7㧕 ⎇ⓥઍ⴫⠪㧦Ꮉፒ㓷ⷙ㧘⎇ⓥಽᜂ⠪㧦ߥߒ㧧ᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ၮ⋚(C)⎇ⓥ㧧౰േ⣂ਇ቟ቯࡊ࡜࡯ࠢᬌ಴ߩߚ߼ߩᣂߒ޿ਃᰴర↹௝᭴▽ⵝ⟎ߩ㐿⊒ߣ⥃ᐥᔕ↪㧧ᐔᚑ 20㧙22 ᐕᐲ㧧3,600 ජ౞(1,300㧦1,400㧦900 ජ౞)
2㧕ฃ⸤⎇ⓥ1㧕 Ḋญା਽㧦ᄤบὖ⮎ߩ᛫േ⣂⎬ൻ૞↪ߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 18 ᐕᐲ㧧500 ජ౞㧦๺᱌ጊ⋵Ꮏᬺᛛⴚ࠮ࡦ࠲࡯2㧕 Ḋญା਽㧦ࠪࡦࡃࠬ࠲࠴ࡦߩ᪪Ⴇࠨࠗ࠭❗ዊലᨐ࡮࡝ࡕ࠺࡝ࡦࠣᡷༀലᨐߦߟ޿ߡߩᬌ⸛㧧ᐔᚑ 18
㧙19 ᐕᐲ㧧2,100 ජ౞㧦ਁ᦭⵾⮎ᩣᑼળ␠3㧕 ┻᧛రਃ㧦ࠛ࡝ࠬࡠࡐࠛ࠴ࡦߩᔃਇోᡷༀലᨐߩᬌ⸛㧧ᐔᚑ 17㧙19 ᐕᐲ㧧2,000 ජ౞(1,000㧦1,000㧦
0 ජ౞)㧦ਛᄖ⵾⮎ᩣᑼળ␠4㧕 ⮮ේਭ⟵㧦࡚ࠫ࡯ࠬ࠹ࡦ࠻ࠣ࡜ࡈ࠻ࡑࠬ࠲࡯Ꮢ⽼ᓟ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 16㧙19 ᐕᐲ㧧21 ජ౞㧦ࠕ㧙㧙ࡏ࠶࠻࡮ࡧࠔࠬࠠࡘ࡜࡯࡮࠺ࡃࠗࠪࠬ࡮ࠫࡖࡄࡦᩣᑼળ␠
5㧕 ⮮ේਭ⟵㧘⷏၂๺ᒾ㧘࿯ደ㇌ᒾ㧘ਭ଻↰⍮Ꮧ㧦ࡔ࠼࠻ࡠ࠾࠶ࠢ InSync8040 ෸߮ࠕ࠹ࠗࡦ࡝࡯࠼ߩ
૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 16㧙20 ᐕᐲ㧧ᧂቯ(63㧦105㧦105㧦42 ජ౞)㧦ᣣᧄࡔ࠼࠻ࡠ࠾࠶ࠢᩣᑼળ␠
6㧕 Ḋญା਽㧦ࠢ࡟ࠬ࠻࡯࡞㍤૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 17㧙18 ᐕᐲ㧧210 ජ౞㧦Ⴎ㊁⟵⵾⮎ᩣᑼળ␠7㧕 ⷏၂๺ᒾ㧘Ḋญା਽㧘Ꮉፒ㓷ⷙ㧦౰േ⣂∔ᖚࠍ᦭ߔࠆ㜞ࠦ࡟ࠬ࠹ࡠ࡯࡞ⴊ∝ᖚ⠪ߦ߅ߌࠆࡠࠬࡃࠬ
࠲࠴ࡦ㐳ᦼᛩਈᤨߩⴊ▤ౝ⿥㖸ᵄᬌᩏᴺࠍ↪޿ߚ᦭ലᕈ߅ࠃ߮቟ోᕈߩᬌ⸛㧧ᐔᚑ 17㧙19 ᐕᐲ㧧
2,318.4 ජ౞(1,159.2㧦695.52㧦463.68 ජ౞)㧦Ⴎ㊁⟵⵾⮎ᩣᑼળ␠㧧ᐔᚑ 18 ᐕᐲ㧧472.5 ජ౞㧦
8㧕 Ḋญା਽㧦ࡉࡠࡊ࡟ࠬ㍤․ቯ૶↪ᚑ❣⺞ᩏ‫ޟ‬ᘟᕈᔃਇో㧦㐳ᦼ૶↪‫ޠ‬ᱞ↰⮎ຠᎿᬺᩣᑼળ␠
9㧕 ⷏၂๺ᒾ㧘࿯ደ㇌ᒾ㧘ਭ଻↰⍮Ꮧ㧦ࠕ࠹ࠗࡦ OTW ࡝࡯࠼ߩ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 18㧙20 ᐕᐲ㧧315
ජ౞㧦ᣣᧄࡔ࠼࠻ࡠ࠾࠶ࠢᩣᑼળ␠
10㧕 Ḋญା਽㧦࡝ࡑ࠴࡞㍤ 100mg ߩ೽૞↪⺞ᩏ㧧ᐔᚑ 18㧙20 ᐕᐲ㧧21 ජ౞㧦ෳᄤ⵾⮎ᩣᑼળ␠11㧕 Ḋญା਽㧘᧛↰৻⍮ᦶ㧘᫪㤀㧦ࡉ࡟࠺ࠖ࠾ࡦ㍤ේ⊒ᕈ♻⃿૕∔ᖚࠍේ࿃ߣߔࠆࡀࡈࡠ࡯࠯∝୥⟲․ቯ૶↪ᚑ❣⺞ᩏ(㐳ᦼ૶↪ߦ㑐ߔࠆ⺞ᩏ)㧧ᐔᚑ 18㧙22 ᐕᐲ㧧630 ජ౞㧦ᣩൻᚑࡈࠔ࡯ࡑᩣᑼળ␠
12㧕 Ḋญା਽㧦࠲ࠠ࠰࠹࡯࡞ᵈ೽૞↪⹦⚦⺞ᩏ㧧ᐔᚑ 18 ᐕᐲ㧧21 ජ౞㧦ࠨࡁࡈࠖ࡮ࠕࡌࡦ࠹ࠖࠬᩣᑼ
ળ␠
13㧕 ⷏၂๺ᒾ㧘࿯ደ㇌ᒾ㧘ਭ଻↰⍮Ꮧ㧦ࡔ࠼࠻ࡠ࠾࠶ࠢ InSyncΥࡑ࡯ࠠ࡯ߩ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 19㧙
20 ᐕᐲ㧧ᧂቯ(63 ජ౞)㧦ᣣᧄࡔ࠼࠻ࡠ࠾࠶ࠢᩣᑼળ␠
14㧕 ⷏၂๺ᒾ㧘ਭ଻↰⍮Ꮧ㧦ࠦࡦ࠲࠶ࠢ ࡝࠾ࡘ࡯ࠕ࡞ 4㧘ࠦࡦ࠲࠶ࠢ ࡝࠾ࡘ࡯ࠕ࡞ 4HE ෸߮㧛߽ߒߊߪࠗ࡯ࠫ࡯࠻࡜࠶ࠢ 2 ࡝࡯࠼㧘ࠗ࡯ࠫ࡯࠻࡜࠶ࠢ 2CS ࡝࡯࠼ߩ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 19 ᐕᐲ㧧210
ජ౞㧦ᣣᧄࠟࠗ࠳ࡦ࠻ᩣᑼળ␠
15㧕 ⷏၂๺ᒾ㧘Ḋญା਽㧘Ꮉፒ㓷ⷙ㧦ࡠࠬࡃࠬ࠲࠴ࡦ⵾ㅧ⽼ᄁᓟ⥃ᐥ⹜㛎㧧ᐔᚑ 19 ᐕᐲ㧧463.68 ජ౞㧦Ⴎ㊁⟵⵾⮎ᩣᑼળ␠
16㧕 ⷏၂๺ᒾ㧦ࠪࠣࡑ࡯࠻ᵈ૶↪ᚑ❣⺞ᩏ㧙ᕆᕈᔃਇో㧙㧔ᘟᕈᔃਇోߩᕆᕈჇᖡᦼࠍ฽߻㧕㧧ᐔᚑ 20
ᐕᐲ㧙22 ᐕᐲ㧧ᧂቯ(210 ජ౞)㧦ਛᄖ⵾⮎ᩣᑼળ␠
3㧕౒ห⎇ⓥ1㧕 Ḋญା਽㧦ࠪࡦࡃࠬ࠲࠴ࡦߩ᪪Ⴇࠨࠗ࠭❗ዊലᨐ࡮࡝ࡕ࠺࡝ࡦࠣᡷༀലᨐߦߟ޿ߡߩᬌ⸛㧧ᐔᚑ 18
㧙19 ᐕᐲ㧧2,100 ජ౞㧦ਁ᦭⵾⮎ᩣᑼળ␠2㧕 ┻᧛రਃ㧦ࠛ࡝ࠬࡠࡐࠛ࠴ࡦߩᔃਇోᡷༀലᨐߩᬌ⸛㧧ᐔᚑ 17㧙19 ᐕᐲ㧧2,000 ජ౞(1,000㧦1,000㧦
0 ජ౞)㧦ਛᄖ⵾⮎ᩣᑼળ␠3㧕 Ḋญା਽㧘ᄢ㊁ᐽ㧦ߓ߾߫ࠄߩ᳇▤ᡰ༎ᕷߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 19 ᐕᐲ㧧1,000 ජ౞㧦๺᱌ጊ⋵᧲—ᇋ㇭ർጊ᧛
4㧕 Ḋญା਽㧘ᄢ㊁ᐽ㧦ߓ߾߫ࠄߩ᳇▤ᡰ༎ᕷߦ㑐ߔࠆ⎇ⓥ㧧ᐔᚑ 20 ᐕᐲ㧧1,000 ජ౞㧦๺᱌ጊ⋵᧲—ᇋ㇭ർጊ᧛5㧕 ┻᧛రਃ㧦ᓴⅣེ∔ᖚߦ߅ߌࠆⴊ▤ౣ↢ߩᓎഀ㧧ᐔᚑ 20 ᐕᐲ㧧5,500 ජ౞㧕㧦ᄢႦ⵾⮎ᩣᑼળ␠
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫߥߒ
6㧚ቇળᵴേ
1㧕ቇળᓎຬḊญା਽㧦
1㧕 ᣣᧄᓴⅣེቇળ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄᓴⅣེቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)3㧕 ᣣᧄᓴⅣ೙ᓮකቇળ⹏⼏ຬ(㨪⃻࿷)4㧕 ᣣᧄᔃਇోቇળ⹏⼏ຬ(㨪⃻࿷)5㧕 ᣣᧄᔃ⤳∛ቇળ⹏⼏ຬ(㨪⃻࿷)6㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)7㧕 ᣣᧄ㜞ⴊ࿶ቇળ⹏⼏ຬ(㨪⃻࿷)8㧕 ᣣᧄᔃ⤳࡝ࡂࡆ࡝࠹࡯࡚ࠪࡦቇળ⹏⼏ຬ(㨪⃻࿷)㧙㧙┻᧛రਃ㧦
1㧕 ᣣᧄᓴⅣེቇળ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄᓴⅣེቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)3㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)4㧕 ᣣᧄᔃਇోቇળ⹏⼏ຬ(㨪⃻࿷)5㧕 ᣣᧄ⥃ᐥಽሶᒻᘒቇળ⹏⼏ຬ(㨪⃻࿷)6㧕 ᣣᧄࠕࡐ࠻࡯ࠪࠬ⎇ⓥળ⹏⼏ຬ(㨪⃻࿷)7㧕 ᔃ╭↢ᬌ⎇ⓥળᐙ੐(㨪⃻࿷)8㧕 ࠕࡔ࡝ࠞᔃ⤳∛ቇળ Fellow(㨪⃻࿷)⷏၂๺ᒾ㧦1㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄᓴⅣེቇળᔃ⤳⒖ᬀᆔຬળ࡮ᔃ⤳⒖ᬀㆡᔕᬌ⸛ዊᆔຬળᐙ੐(㨪⃻࿷)3㧕 ᣣᧄᓴⅣེቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)4㧕 ᣣᧄᔃⴊ▤ࠞ࠹࡯࠹࡞ᴦ≮ቇળ⹏⼏ຬ(㨪⃻࿷)5㧕 ᣣᧄᔃⴊ▤ࠞ࠹࡯࠹࡞ᴦ≮ቇળ᧲ᶏർ㒽࿾ᣇળ⹏⼏ຬ(㨪⃻࿷)6㧕 ᣣᧄᔃਇోቇળ⹏⼏ຬ(㨪⃻࿷)7㧕 ᣣᧄᔃ⤳∛ቇળ⹏⼏ຬ(㨪⃻࿷)8㧕 ᣣᧄᓴⅣེቇળ‫ޡ‬౰േ⣂∔ᖚߦ߅ߌࠆࠗࡦ࠲࡯ࡌࡦ࡚ࠪࡦᴦ≮ߩㆡᔕࠟࠗ࠼࡜ࠗࡦ㧔౰േ⣂ࡃࠗࡄࠬⴚߩㆡᔕࠍ฽߻㧕ᓙᯏ⊛ࠗࡦ࠲࡯ࡌࡦ࡚ࠪࡦ‫ޢ‬ᡷ⸓ ⃰ຬ࡮੐ോዪ(㨪⃻࿷)9㧕 ᣣᧄᓴⅣེቇળ‫ޡ‬Ꮉፒ∛ᔃ⤳ⴊ▤ᓟㆮ∝ߩ⸻ᢿߣᴦ≮ߦ㑐ߔࠆࠟࠗ࠼࡜ࠗࡦ‫ޢ‬ᡷ⸓ ⃰ຬ(㨪⃻࿷)Ꮉፒ㓷ⷙ㧦1㧕 ᣣᧄᓴⅣེቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)3㧕 ᣣᧄᔃⴊ▤↹௝േᘒቇળ⹏⼏ຬ(㨪⃻࿷)㕍ጊ℉⏴㧦1㧕 ᣣᧄᓴⅣེቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)ᄢ㊁ᐽ㧦
1㧕 ᣣᧄ๭ๆེቇળ⹏⼏ຬ(㨪⃻࿷)2㧕 ᣣᧄ⢖≸ቇળ⹏⼏ຬ(㨪⃻࿷)3㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)2㧕ቇળ㐿௅
ߥߒ
3㧕ቇⴚ㔀⹹
Ḋญା਽㧦
1㧕 Circ.J. Editorial board (㨪⃻࿷)2㧕 Journal of Life Style Medicine‫ޡ‬Life Style Medicine‫✬ޢ‬㓸ᆔຬ(㨪⃻࿷)⷏၂๺ᒾ㧦1㧕 ᣣᧄᔃⴊ▤ࠞ࠹࡯࠹࡞ᴦ≮ቇળ㔀⹹‫ޡ‬JACCT‫✬ޢ‬㓸㘈໧(㨪⃻࿷)7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳⮮ේਭ⟵㧦
1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Late Breaking Clinical Trials
in Japan‫ޟ‬J-SAP Study Outcomes of Patients with Low Risk Angina Receiving Medical -and PCIPreceding Therapies in Japan‫ޠ‬Ṷ⠪)
2㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘ળ㐳⻠Ṷ‫ޟ‬Regeneration㧙㧙Medicine as the Ultimate Medicine‫ޠ‬Ṷ⠪)
3㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘ᣣᧄᔃ⤳⽷࿅૒⮮⾨ฃ⾨⸥ᔨ⻠Ṷ‫ޟ‬Identification of Genetic Factors and Development of Genetic Risk Diagnosis Systems for
Cardiovascular Deseases‫ޠ‬ᐳ㐳)
4㧕 ╙ 2 ࿁㧔ㅢ▚ 23 ࿁㧕ਛ㑆ᴺੱᣣᧄ⥃ᐥౝ⑼කળ✚ળ(ᐔᚑ 18 ᐕ 4 ᦬㧘ᮮᵿ㧘․೎⻠Ṷ‫ޟ‬༛ᾍߪ∔ᖚ㧘༛ᾍ⠪ߪᖚ⠪̆9 ቇળวห⑌ᾍࠟࠗ࠼࡜ࠗࡦࠍਛᔃߦ̆‫ޠ‬Ṷ⠪)
5㧕 ╙ 36 ࿁ᣣᧄౝ⑼ቇળർᶏ㆏ᡰㇱ↢ᶦᢎ⢒⻠Ṷળ(ᐔᚑ 18 ᐕ 9 ᦬㧘ᧅᏻ㧘․೎⻠Ṷ‫ޟ‬ᚒ߇࿖ߩ⁜ᔃ∝࡮ᔃ╭᪪Ⴇᴦ≮ߩ໧㗴ὐ‫ޠ‬Ṷ⠪)Ḋญା਽㧦
1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Symposium2(IHD)‫ޟ‬Pharmacological Intervention for Coronary Artery Disease‫ޠ‬ᐳ㐳)2㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Symposium2(IHD)‫ޟ‬D㧙
Glucosdsse Inhibitorsane protective against ischemia / reperfusion injury‫ޠ‬Ṷ⠪)
3㧕 ᣣᧄ૕ജකቇળ✚ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ጘ㒂㧘⻠Ṷ‫ޟ‬ౣ↢කቇ߆ࠄౣ↢ක≮߳㧙․ߦᓴⅣེ∔ᖚߦߟ޿ߡ㧙‫ޠ‬Ṷ⠪)
4㧕 ╙ 71 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 19 ᐕ 3 ᦬㧘␹ᚭ㧘Featured Research Session16(H)‫ޟ‬Vascular Injury and Neointimal Formation in Animal Models(basic) ‫ޠ‬ᐳ㐳)
5㧕 ╙ 71 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 19 ᐕ 3 ᦬㧘␹ᚭ㧘࡜ࡦ࠴࡚ࡦ࠮ࡒ࠽࡯‫ⴊ⯯ޟ‬ᔃ╭଻⼔ߣ Ca ᜟ᛫⮎‫ޠ‬Ṷ⠪)
6㧕 ᣣᧄ NO ቇળ(ᐔᚑ 19 ᐕ 6 ᦬㧘ᄢᵤ㧘․೎⻠Ṷ 2‫ޟ‬NO ߣ⯯ⴊᔃ╭଻⼔‫ޠ‬Ṷ⠪)7㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ↢ᶦᢎ⢒⻠Ṷળ(ᐔᚑ 19 ᐕ 10 ᦬㧘ฬฎደ㧘⻠Ṷ‫ޟ‬ฦ⒳ᓴⅣེ⮎ࠍ↪޿ߚ⯯ⴊᔃ╭଻⼔‫ޠ‬Ṷ⠪)8㧕 ╙ 72 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 20 ᐕ 3 ᦬㧘⑔ጟ㧘Symposium1(IHD)‫ޟ‬DES ᤨઍߩ⮎‛≮ᴺࠍౣ⹏ଔߔࠆ‫ޠ‬ᐳ㐳)9㧕 ╙ 72 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 20 ᐕ 3 ᦬㧘⑔ጟ㧘Plenary Session2(IHD)‫ޟ‬A Low
Dose but Long Duration Post-myocardial Infarction Treatment with Granulocyte
Colony-stimulating Factor Shows a Beneficial Effect without any Complications‫ޠ‬Ṷ⠪)⷏၂๺ᒾ㧦
1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Controversy1(IHD/M)‫ޟ‬ᣣᧄੱߩૐᏀቶᯏ⢻ᖚ⠪ߩ੍ᓟߣᴦ≮ㆬᛯ‫ޠ‬ᐳ㐳)2㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Luncheon Seminar 38 ⯯ⴊᔃ╭଻⼔ -Pharmacological preconditioning ߣ ischemic postconditioning- ⻠Ṷ 1 ‫ޟ‬Sarpogrelate,a 5-HT2 receptor blocker, have an ischemic preconditioning-like effect‫ޠ‬Ṷ⠪)
3㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘ᣣᧄᓴⅣེቇળᆔຬળᵴേ㧔ᔃ
⤳⒖ᬀᆔຬળ㧕╙ 2 ࿁ᔃ⤳⒖ᬀ࠮ࡒ࠽࡯ ‫ޟ‬ᬀ߃ㄟߺဳ⵬ഥᔃ⤳ߩ⃻⁁ߣ੹ᓟߩ⺖㗴‫⻠ޠ‬Ṷ ႎ๔ 1‫߇ࠊޟ‬࿖ߦ߅ߌࠆᔃ⤳⒖ᬀߩ⃻ᴫ‫ޠ‬Ṷ⠪)
4㧕 ᣣᧄᓴⅣེቇળ╙ 128 ࿁᧲ᶏ࡮╙ 113 ࿁ർ㒽วห࿾ᣇળ ࠨ࠹࡜ࠗ࠻ᢎ⢒⻠Ṷ(ᐔᚑ 18 ᐕ 11 ᦬㧘ฬฎደ㧘‫ޟ‬㐳ᦼ੍ᓟ߆ࠄ⷗ߚ⁜ᔃ∝ߩᴦ≮ᚢ⇛‫⹤ޠ‬㗴ឭଏ 3 ‫ޟ‬ૐ࡝ࠬࠢ⁜ᔃ∝ߩ㐳ᦼ੍ᓟ гPCI వⴕ≮ᴺߣ⮎‛వⴕ≮ᴺߩᲧセг‫ޠ‬Ṷ⠪)┻᧛రਃ㧦
1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Meet the Expert3(M)‫ޟ‬Morphology Revisited㧙ᓴⅣེ∛⎇ⓥ࡮⥃ᐥߦ߅ߌࠆᒻᘒቇߩ૏⟎ઃߌ‫ޠ‬ᐳ㐳)2㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘Plenary Session-3㧦 Cell Deathand Repair –Regeneration in Cardiac and Vascular Diseases “Distinct Features of Apoptosis andRegeneration in Cardiac Myocytes and Nonmyocytes”Ṷ⠪)ฬฎደ㧘Meet the Expert-3㧦 Morphology
3㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘
Revisited: ᓴⅣེ∛⎇ⓥ࡮⥃ᐥߦ߅ߌࠆᒻᘒቇߩ૏⟎ઃߌ“Electron Microscopic Cytochemistry: A
Tool for Bridging Structures with Function and Molecular Events and for More”Ṷ⠪)4㧕 The Annual Scientific Meeting of American Heart Association (2006.11, Chicago, IL, USA,
Cardiovascular Seminar #59: AHA-JCS Joint Symposium: Myocyte Death in Heart㧙㧙failure-Autophagy, Apoptosis and Necrosis: “Apoptosis and autophagy in failing heart”;
Symposist)Ꮉፒ㓷ⷙ㧦1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘TOPICS 5 Beyond Conventional
Signal Analysis ᐳ㐳)8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫ1㧕 Ꮉፒ㓷ⷙ㧦⽷࿅ᴺੱ࿾ၞකቇ⎇ⓥၮ㊄⎇ⓥഥᚑ․೎ᅑബ⾨(ᐔᚑ 18 ᐕᐲ)
2㧕 ਭ଻↰⍮Ꮧ㧦ᄖጊၮ㊄ߦࠃࠆ࿖㓙੤ᵹഥᚑ(ᐔᚑ 18 ᐕᐲ)
3㧕 ⍹ේ⟵ਯ㧦⽷࿅ᴺੱක⑼ቇᔕ↪⎇ⓥ࿅࿖㓙੤ᵹഥᚑ(ᐔᚑ 19 ᐕᐲ)
4㧕 Ꮉፒ㓷ⷙ㧦㜞ⴊ࿶ߣ౰േ⣂∔ᖚ⎇ⓥળ⎇ⓥഥᚑ⎇ⓥ․೎⾨(ᐔᚑ 19 ᐕᐲ)
5㧕 ┻᧛రਃ㧦ᐔᚑ 19 ᐕጘ㒂ᄢቇᵴᕈൻ⚻⾌(ᐔᚑ 19 ᐕᐲ)
6㧕 ⷏၂๺ᒾ㧦╙ 11 ࿁ᣣᧄᔃਇోቇળቇⴚ㓸ળఝ⑲Ṷ㗴⾨(ᐔᚑ 19 ᐕᐲ)
7㧕 Ḋญା਽㧦㋈ᧁ⻞ਃ⸥ᔨ⽷࿅ᴺੱක⑼ቇᔕ↪⎇ⓥ⽷࿅ ⎇ⓥഥᚑ㊄(ᐔᚑ 20 ᐕᐲ)
8㧕 ⩆㊁ᢕผ㧦╙ 46 ࿁ጘ㒂⋵ౝ⑼කળ⻠Ṷળጘ㒂⋵ౝ⑼කળᅑബ⾨(ᐔᚑ 20 ᐕᐲ)
9㧕 ㊄᫪ኡల㧦╙ 12 ࿁ᣣᧄᔃਇోቇળቇⴚ㓸ળ YIA ఝ⑲⾨(ᐔᚑ 20 ᐕᐲ)
10㧕 ㊄᫪ኡల㧦╙ 30 ࿁ᔃ╭↢ᬌ⎇ⓥળ⧯ᚻᅑബ⾨(ᐔᚑ 20 ᐕᐲ)
9㧚␠ળᵴേ
ߥߒ
10㧚ႎ๔ᦠ
1㧕 ⮮ේਭ⟵㧦᜛ᒛဳᔃ╭∝ߦኻߔࠆ㗰☸⃿ࠦࡠ࠾࡯ೝỗ࿃ሶࠍ↪޿ߚ㕖ଚⷅᕈౣ↢ක≮ߩ᜸ᚢ㧦ᐔᚑ
15 ᐕᐲ㧙17 ᐕᐲᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ⎇ⓥᚑᨐႎ๔ᦠ㧦1㧙150(2006 ᐕ 5 ᦬)
2㧕 Ḋญା਽㧦ᔃ╭᪪Ⴇߦኻߔࠆ G-CSF ലᨐߩᣂߒ޿ࡔࠞ࠾࠭ࡓ‫ޔ‬ᴦ≹ㆊ⒟ଦㅴലᨐߩಽሶᯏ᭴㧦ᐔᚑ
16 ᐕᐲ㧙17 ᐕᐲᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ⎇ⓥᚑᨐႎ๔ᦠ㧦1㧙11(2006 ᐕ 5 ᦬)
3㧕 ⷏၂๺ᒾ㧦㗰☸⃿ࠦࡠ࠾࡯ೝỗ࿃ሶ(G㧙CSF)ࠍ↪޿ߚ㔍ᴦᕈ⁜ᔃ∝ߦኻߔࠆౣ↢ක≮ߩ㐿⊒㧦ᐔᚑ
16 ᐕᐲ㧙17 ᐕᐲᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ⎇ⓥᚑᨐႎ๔ᦠ㧦1㧙52(2006 ᐕ 5 ᦬)
4㧕 ┻᧛రਃ㧦ᄢဳ᪪Ⴇᓟᔃਇోߦኻߔࠆࠕࡐ࠻࡯ࠪࠬ㒖ኂߥࠄ߮ߦᔃ╭ౣ↢ߩ૬↪≮ᴺߩ⹜ߺ㧦ᐔᚑ
16 ᐕᐲ㧙17 ᐕᐲᢥㇱ⑼ቇ⋭⑼ቇ⎇ⓥ⾌⵬ഥ㊄ ⎇ⓥᚑᨐႎ๔ᦠ㧦1㧙59(2006 ᐕ 5 ᦬)
11㧚ႎ㆏1㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 12
ᣣ)2㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 14
ᣣ)3㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 16
ᣣ)4㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 18
ᣣ)5㧕 ⮮ේਭ⟵㧦ᔃ⤳∛ࠞ࠹࡯࠹࡞ᴦ≮ᣣᧄߪታᣉㆊᄙ㧫࿖㓙ࠪࡦࡐߢႎ๔㧦ᣣᧄ⚻ᷣᣂ⡞(2006 ᐕ 2 ᦬
20 ᣣ)
6㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 22
ᣣ)7㧕 ⮮ේਭ⟵㧦ᕆᕈᔃ╭᪪Ⴇߩේ࿃‛⾰⿥㖸ᵄߢᣧᦼߦ․ቯ㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 23 ᣣ)
8㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 23
ᣣ)9㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 25
ᣣ)10㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ਛᣣᣂ⡞(2006 ᐕ 2 ᦬ 25
ᣣ)11㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 26

㧙㧙

ᣣ)
12㧕 ⮮ේਭ⟵㧦ᓴⅣེක≮ߩߐࠄߥࠆ⊒ዷ࡮ㅴᱠࠍ߼ߑߒߡ㧦ਛᣣᣂ⡞(2006 ᐕ 2 ᦬ 28 ᣣ)
13㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 2 ᦬ 28
ᣣ)14㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 3 ᦬ 1ᣣ)15㧕 ⮮ේਭ⟵㧦╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ‫ޟ‬Ꮢ᳃౏㐿⻠ᐳ‫ޠ‬㧦ᦺᣣᣂ⡞(2006 ᐕ 3 ᦬ 2ᣣ)16㧕 ⮮ේਭ⟵㧦‫ޟ‬༛ᾍߪ∛᳇‫ߦޠ‬ᛶ᛫൓ജߩო㧦⺒ᄁᣂ⡞(2006 ᐕ 3 ᦬ 9 ᣣ)
12㧚⥄Ꮖ⹏ଔ
⹏ଔ
ฦಽ㊁ߢߩ⎇ⓥ߇㗅⺞ߦㅴⴕߒ㧘৻ᵹߩࠫࡖ࡯࠽࡞ߦ಴ ߐࠇ㧘2005 ᐕߪ⧷ᢥ⺰ᢥᢙ 17 ߢࠗࡦࡄࠢ
࠻ࡈࠔࠢ࠲࡯߇ 40 ὐ㧘2006 ᐕߪ⧷ᢥ⺰ᢥᢙ 26 ߢࠗࡦࡄࠢ࠻ࡈࠔࠢ࠲࡯߇ 85 ὐ㧘2007 ᐕߪ⧷ᢥ⺰ᢥ
ᢙ 17 ߢࠗࡦࡄࠢ࠻ࡈࠔࠢ࠲࡯߇ 47 ὐ㧘2008 ᐕߪ⧷ᢥ⺰ᢥᢙ 17 ߢ޽ߞߚ‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷ᄙᢙߩᄢቇ㒮↢߿⎇ⓥ⠪ࠍᛴ߃㧘࠺ࠬࠢ߿ࠬࡍ࡯ࠬࠍ⏕଻ߔࠆߎߣߦ࿎㔍ߒߡ޿ࠆ‫⥃ߚ߹ޕ‬ᐥ㧘ᢎ⢒,⎇ⓥߩ޿ߕࠇߦ߽ᤨ㑆ࠍ⾌߿ߔߚ߼㧘⎇ⓥߦචಽߥᤨ㑆߇޽ࠆߣߪ⸒޿㔍޿‫ޕ‬੹ᓟߩዷᦸ㜞㦂ൻߥࠄ߮ߦ↢ᵴ᭽ᑼߩ᰷☨ൻߦ઻޿㧘ᓴⅣེ∔ᖚ㧘⣢⤳∔ᖚߪჇടߩ৻ㅜࠍㄡߞߡ޿ࠆ‫ߙࠇߘޕ‬ࠇߩ∛᳇ߩࡔࠞ࠾࠭ࡓࠍേ‛ታ㛎㧘⥃ᐥ⎇ⓥࠍㅢߓߡ⸃᣿ߒ㧘ᴦ≮ߦᔕ↪ߒߡ޿ߊߎߣ߇㊀ⷐߢ޽ࠆ‫ޕ‬੹ᓟ㧘ᓴⅣེ∔ᖚ㧘⣢⤳∔ᖚߩಽ㊁ߦ߅޿ߡ⚦⢩ᱫߥࠄ߮ߦ⚦⢩ᄌᕈ㧔ࠕࡐ࠻࡯ࠪࠬ㧘ࠝ࡯࠻ࡈࠔࠫ࡯
╬㧕㧘⚦⢩ࠍౣ↢ߔࠆౣ↢කቇߥߤ߇߹ߔ߹ߔ㊀ⷐߥ⎇ⓥ࠹࡯ࡑߣߥࠆߎߣ߇੍ᗐߐࠇࠆ‫ޕ‬ᓥߞߡᚒ‫ߪޘ‬ߎߩὐࠍචಽ⹺⼂ߒ㧘⚦⢩↢‛ቇ⊛ᚻᴺࠍ㚟૶ߒᣂߒ޿࠺ࡃࠗࠬࠍዉ౉ߒߡ㧘ߐࠄߦᵴ⊒ߥ⎇ⓥᵴേࠍ
ⴕߞߡ޿߆ߥߊߡߪߥࠄߥ޿ߣ⠨߃ࠆ‫ޕ‬㧙㧙㧔2㧕๭ๆ∛ᘒቇಽ㊁1㧚⎇ⓥߩ᭎ⷐ
1㧕ౣ↢කቇ
1㧕COPD㧘⢖✢⛽∝ߦኻߔࠆ㛽㜑ᐙ⚦⢩⒖ᬀߦࠃࠆౣ↢කቇ࡮ක≮2㧕G-CSF㧔㗰☸⃿ࠦࡠ࠾࡯ೝỗ࿃ሶ㧕ࠍ↪޿ߚ COPD㧘⢖✢⛽∝ߦኻߔࠆౣ↢≮ᴺߩ㐿⊒
2㧕ࠕࡐ࠻࡯ࠪࠬ࡮ࠝ࡯࠻ࡈࠔࠫ࡯
1㧕๭ๆེ∔ᖚߣࠕࡐ࠻࡯ࠪࠬ
⢖⢩✢⛽⧘⚦⢩ࠕࡐ࠻࡯ࠪࠬ㒖ኂߦࠃࠆ࡝ࡕ࠺࡝ࡦࠣߩ੍㒐
3㧕COPD ߩࡔࠞ࠾࠭ࡓ⸃᣿ߣ new drug ߩ㐿⊒1㧕㉄ൻࠬ࠻࡟ࠬߣ๭ๆེ∔ᖚ㧔COPD㧘᳇▤ᡰ༎ᕷ㧘⢖✢⛽∝㧕ߩࡔࠞ࠾࠭ࡓ⸃᣿
2㧕᛫㉄ൻ⮎ߢ޽ࠆ Tetomilast ߦࠃࠆ⢖⢩଻⼔૞↪ߩࡔࠞ࠾࠭ࡓ⸃᣿
3㧕ࡠࠗࠦ࠻࡝ࠛࡦᜟ᛫⮎ߩ COPD ߦኻߔࠆ૞↪ߩࡔࠞ࠾࠭ࡓ⸃᣿
4㧕ㆮવሶᴦ≮1㧕⢖߇ࠎߦኻߔࠆ RhoC ߦࠃࠆㆮવሶᴦ≮2㧕⢖✢⛽∝ߦኻߔࠆ HGF ߩㆮવሶᴦ≮5㧕IB-EBUS ߅ࠃ߮ IB-ࠛࠦ࡯ߦࠃࠆ⚵❱ᕈ⁁⸻ᢿ
1㧕᛫㉄ൻ⮎ߩ᳇㆏਄⊹ߦਈ߃ࠆᓇ㗀ߩ⸃ᨆ
2㧕᳇㆏࡝ࡕ࠺࡝ࡦࠣߩ progression ߣ⚵❱∛ᄌ
3㧕⢖∛ᄌߩ⚵❱ᕈ⁁⸻ᢿ
4㧕⢖߇ࠎ∝଀ߩ⚵❱ᕈ⁁㧘࡝ࡦࡄ▵⸻ᢿ
6㧕COPD ߩ∛ᘒߦኻߔࠆಽሶ↢‛ቇ⊛ࠕࡊࡠ࡯࠴
1㧕Free Radical Scavenger ߦࠃࠆᴦ≮ᴺߩ㐿⊒
7㧕3D-CT ߦࠃࠆ᳇㆏∛ᄌ⸻ᢿ
1㧕3D-CT ↹௝ߣ IB-EBUS ↹௝ߣߩ⚵❱ᕈ⁁⸻ᢿᲧセ8㧕⌧⌁ᤨή๭ๆ
1㧕CPAP ߦࠃࠆ⌧⌁ᤨή๭ๆᴦ≮
2㧕COPD ߣ sleep apnea ߩ㑐ଥ9㧕᳇▤ᡰࠗࡦ࠲࡯ࡌࡦ࡚ࠪࡦ
1㧕⢖߇ࠎߦኻߔࠆ࡟࡯ࠩ࡯≮ᴺߩ㐿⊒
2㧕ᣂߚߥ᳇㆏ࠬ࠹ࡦ࠻≮ᴺߩ㐿⊒
3㧕⢖ᔃ⣢ㅪ㑐ߦ㑐ߔࠆ⎇ⓥ
10㧕 ⥃ᐥᩭකቇ
1㧕ࠨ࡞ࠦࠗ࠼࡯ࠪࠬߥߤߩᩭකቇ⊛ᬌ⸛
2㧕PET/CT ߦᣈߌࠆ IB-EBUS ߣߩ㑐ଥ11㧕 ᧲ᵗකቇ⊛ࠕࡊࡠ࡯࠴
1㧕ᄤบὖ⮎ߩ⢖߇ࠎߦኻߔࠆലᨐߩᬌ⸛
2㧕ߓ߾߫ࠄߩ᛫ࠕ࡟࡞ࠡ࡯૞↪ߩᬌ⸛Ԙࠕ࠻ࡇ࡯ᕈ⊹⤏Ἳࡕ࠺࡞ࡑ࠙ࠬߦࠃࠆᬌ⸛
ԙ᳇▤ᡰ༎ᕷࡑ࠙ࠬߦኻߔࠆᬌ⸛
Ԛ⧎☳∝ᖚ⠪ߦኻߔࠆᬌ⸛
12㧕 㑐ㅪ∛㒮ߣߩᄢⷙᮨ⥃ᐥ⹜㛎
1㧕ᘟᕈ⢖ࠕࠬࡍ࡞ࠡ࡞ࠬ∝ߩᄙᣉ⸳౒ห⎇ⓥ
2㧕⢖߇ࠎࠢ࡝࠾ࠞ࡞ࡄࠬߩ᦭ലᕈߩᬌ⸛
3㧕ᄤบὖ⮎ߩ⢖߇ࠎߦኻߔࠆ᦭ലᕈߩᬌ⸛
13㧕 ᳇▤ᡰౝⷞ㏜ᬌᩏ
2㧚ฬ★
ᢎ᝼(૬છ)㧦
⻠Ꮷ㧦
කຬ㧦
කຬ㧦
කຬ㧦
කຬ㧦

Ḋญା਽
ᄢ㊁ ᐽ
⥱ญ␸ᒾ
᫪ ⑲ᴺ
㆙ᷰ⚐ノ
દ⮮ᢥ㓉

Shinya Minatoguchi
Yasushi Ohno
Norihiko Funaguchi
Hidenori Mori
Junki Endo
Fumitaka Ito㧙㧙3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
ߥߒ⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
1㧕 ᄢ㊁ ᐽ㧚᳇▤ᡰࡆ࠺ࠝࠬࠦ࡯ࡊࠍ૶↪ߔࠆⰯశ᳇▤ᡰౝⷞ㏜↹௝ߦߟ޿ߡ ᣣᧄ⢖≸ቇળ᳇▤ᡰ㏜ᚲ⷗
ಽ㘃ᆔຬળ ⢖≸ 2007 ᐕ㧧47 Ꮞ㧦215㧙221㧚
2㧕 ᄢ㊁ ᐽ㧚⢖≸ⴚ೨࡝ࡦࡄ▵ォ⒖⸻ᢿߦ߅ߌࠆ‫⿛ࠬࠢ࠶ࡌࡦࠦޔ‬ᩏᑼ⿥㖸ᵄ᳇▤ᡰ㏜ࠟࠗ࠼ਅ↢ᬌ
㧔EBUS-TBNA㧕ߩታ㓙 ᣣᧄ⢖≸ቇળ᳇▤ᡰ㏜ᚲ⷗ಽ㘃ᆔຬળ ⢖≸ 2007 ᐕ㧧47 Ꮞ㧦207㧙214㧚✚⺑㧔᰷ᢥ㧕
ߥߒේ⪺㧔๺ᢥ㧕
1㧕 ㋈ᧁ㓷㓶㧘ᄢ㊁ᐽ㧘ᄢ㊁ፏሶ㧘ᳯᎹ㓷ੱ㧘⧣᧛ஜᴦ㧘⿒የᷡ೰㧘⍫㊁ᔘ㧘⮮ේਭ⟵㧚㎞ᴦ≮߇᦭ലߢ޽ߞ
ߚ߮߹ࠎᕈ᳢⚦᳇▤ᡰἻߩ৻∝଀ ోᣣᧄ㎞ἲቇળ㔀⹹ 2007 ᐕ㧧57㧦621㧙632.
2㧕 ⥱ญ␸ᒾ㧘ᄢ㊁ᐽ㧘㆙ᷰ⚐ノ㧘દ⮮ᢥ㓉㧘᫪⑲ᴺ㧘↱᦬⧷ⴕ㧘Ỉ↰᣽ᶈ㧘⮮ේਭ⟵㧚ਛᨔᕈ๭ๆਇోࠍ߈
ߚߒߚዊ⚦⢩⢖≸ว૬᛫ Hu ᛫૕㓁ᕈற⣲≌␹⚻∝୥⟲ߩ 1 ଀ ᣣᧄ๭ๆེቇળ㔀⹹ 2008 ᐕ㧧46 Ꮞ㧦
314㧙318.
ේ⪺㧔᰷ᢥ㧕
1㧕 Yuhgetsu H, Ohno Y, Funaguchi N, Asai T, Sawada M, Takemura G, Minatoguchi S, Fujiwara T,
Fujiwara H. Beneficial effects of autologous bone marrow mononuclear cell transplantation via thetrachea against elastase-induced emphysema in rabbits. Exp Lung Res. 2006;32:413-426.
2㧕 Asai T, Ohno Y, Minatoguchi S, Funaguchi N, Yuhgetsu H, Sawada M, Takemura G, Komada A,
Fujiwara T, Fujiwara H. The specific free radical scavenger edaravone suppresses bleomycin-induced
acute pulmonary injury in rabbits. Clin Exp Pharmacol Physiol. 2007;34:22-26.
3㧕 Funaguchi N, Ohno Y, La BL, Asai T, Yuhgetsu H, Sawada M, Takemura G, Minatoguchi S, Fujiwara T,
Fujiwara H. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol
Physiol. 2007;34:766-770.
4㧕 Sawada M, Ohno Y, La BL, Funaguchi N, Asai T, Yuhgetsu H, Takemura G, Minatoguchi S, Fujiwara
H, Fujiwara T. The fas/fas-ligand pathway does not mediate the apoptosis in elastase-induced
emphysema in mice. Exp Lung Res. 2007;33:277-288.

IF 1.427

IF 1.780

IF 1.780

IF 1.4274㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄ߥߒ
2㧕ฃ⸤⎇ⓥ
1㧕 ᄢ㊁ᐽ㧘⥱ญ␸ᒾ㧘ᧁ᧛ᥙᄦ㧦CSS࡮AGA ࠍኻ⽎ߣߒߚ GGS ߩੑ㊀⋤ᬌᛩਈᤨᦼή૞ὑൻ೨ᓟᲧセ⹜㛎(╙Υ⋧⥃ᐥ⹜㛎)㧧ᐔᚑ 18㧙19 ᐕᐲ㧧321.3 ජ౞㧦Ꮲੱࡈࠔ࡯ࡑᩣᑼળ␠
2㧕 ᄢ㊁ᐽ㧦ࠕ࡝ࡓ࠲ᵈ኿↪ 500mg ․ቯ૶↪ᚑ❣⺞ᩏ㧔ᖡᕈ⢷⤑ਛ⊹⣲㧕㧧ᐔᚑ 19㧙20 ᐕᐲ㧧126 ජ౞㧦ᣣᧄࠗ࡯࡜ࠗ࡝࡝࡯ᩣᑼળ␠
3㧕 ᄢ㊁ᐽ㧘⥱ญ␸ᒾ㧘㆙ᷰ⚐ノ㧘᫪⑲ᴺ㧘દ⮮ᢥ㓉㧦࠲࡞࠮ࡃ㍤․ቯ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 19㧙20 ᐕᐲ㧧
472.5 ජ౞㧦ਛᄖ⵾⮎ᩣᑼળ␠4㧕 ᄢ㊁ᐽ㧘⥱ญ␸ᒾ㧘㆙ᷰ⚐ノ㧘᫪⑲ᴺ㧘દ⮮ᢥ㓉㧦ࠗ࠻࡝࠱࡯࡞ᵈ 1%૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 19㧙20
ᐕᐲ㧧210 ජ౞㧦ࡗࡦ࠮ࡦࡈࠔ࡯ࡑᩣᑼળ␠㧔╙ੑᦼ㧕㧧ᐔᚑ 20 ᐕ
5㧕 ᄢ㊁ᐽ㧦ࠢ࡝ࠕࠢ࠲࡯ᵈ․ቯ૶↪ᚑ❣⺞ᩏ‫ޟ‬ᕆᕈ⢖Ⴇᩖ∝ߦ㑐ߔࠆో଀⺞ᩏ‫ޠ‬ᐲ㧧157.5 ජ౞㧦ࠛ࡯ࠩࠗᩣᑼળ␠
6㧕 ᄢ㊁ᐽ㧘⥱ญ␸ᒾ㧘㆙ᷰ⚐ノ㧘᫪⑲ᴺ㧘દ⮮ᢥ㓉㧦ࠫࠚ࠾࠽࠶ࠢ㍤ 200mg ૶↪ᚑ❣⺞ᩏ㧧ᐔᚑ 20
ᐕᐲ㧧105 ජ౞㧦ᄢᱜንጊක⮎ຠᩣᑼળ␠
㧧ᐔᚑ
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20 ᐕᐲ㧧157.5 ජ౞㧦ᄢ㢈⮎ຠᎿᬺᩣᑼળ␠㧙㧙3㧕౒ห⎇ⓥ
1㧕 ᄢ㊁ᐽ㧦๭ๆེ∔ᖚߦ߅ߌࠆ㉄ൻࠬ࠻࡟ࠬߩᓎഀ㧧ᐔᚑ 19 ᐕᐲ㧧5,920 ජ౞㧦ᄢႦ⵾⮎ᩣᑼળ␠2㧕 ᄢ㊁ᐽ㧦๭ๆེ∔ᖚߦ߅ߌࠆ㉄ൻࠬ࠻࡟ࠬߩᓎഀ㧧ᐔᚑ 20 ᐕᐲ㧧11,420 ජ౞㧦ᄢႦ⵾⮎ᩣᑼળ␠3㧕 ᄢ㊁ᐽ㧦Elastase 㓚ኂ⢖᳇⣲ࡕ࠺࡞ࡑ࠙ࠬߦኻߔࠆ Montelukast ߦࠃࠆ᦭ലᕈߩᬌ⸛㧧ᐔᚑ 20 ᐕ
ᐲ㧧2,600 ජ౞㧦ਁ᦭⵾⮎ᩣᑼળ␠
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1㧕 ᣣᧄ๭ๆེቇળઍ⼏ຬ࡮ࡊࡠࠣ࡜ࡓᆔຬ(㨪⃻࿷)2㧕 ᣣᧄ๭ๆེౝⷞ㏜ቇળጘ㒂࿾඙ᐙ੐(㨪⃻࿷)3㧕 ᣣᧄ⢖≸ቇળ⹏⼏ຬ(㨪ᐔᚑ 20 ᐕ 11 ᦬)࡮᳇▤ᡰ㏜ᚲ⷗ಽ㘃ᆔຬ(㨪⃻࿷)4㧕 ᣣᧄౝ⑼ቇળ᧲ᶏᡰㇱ⹏⼏ຬ(㨪⃻࿷)2㧕ቇળ㐿௅
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7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳ߥߒ
8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫߥߒ9㧚␠ળᵴേ
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10㧚ႎ๔ᦠߥߒ11㧚ႎ㆏ߥߒ12㧚⥄Ꮖ⹏ଔ
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๭ๆེಽ㊁ߢߩ⎇ⓥ߇㗅⺞ߦㅴⴕߒ㧘৻ᵹߩࠫࡖ࡯࠽࡞ߦ಴ ߐࠇ㧘࿖㓙ቇળߢ߽⊒⴫ࠍⴕߞߚ‫ᦨޕ‬ᣂߩක≮ᛛⴚߣߒߡࠟࠗ࠼ࠪ࡯ࠬᴺࠍ↪޿ߚᧃ᪳⢖∛ᄌߩ⸻ᢿ㧘ᭂ⚦ᓘ᳇▤ᡰ㏜ࠍ↪޿ߚ CT ࠟࠗ࠼ਅ᳇▤ᡰ㏜㧘ਛᨔ᳇▤ᡰߦኻߔࠆ᳇▤ᡰ⣧ౝᾖ኿㧘᳇▤ᡰ⿥㖸ᵄౝⷞ㏜ਅๆᒁ㊎↢ᬌ㧔EBUS-TBNA㧕ߥߤࠍⓍᭂ⊛ߦዉ౉ߒ㧘⋵ౝᄖ߆ࠄߏଐ㗬ࠍฃߌ㧘∝଀ߩ⫾Ⓧࠍߒߡ޿ࠆ‫ޕ‬⃻⁁ߩ໧㗴ὐ߅ࠃ߮ߘߩኻᔕ╷ᄙᢙߩᄢቇ㒮↢߿⎇ⓥ⠪ࠍᛴ߃㧘࠺ࠬࠢ߿ࠬࡍ࡯ࠬࠍ⏕଻ߔࠆߎߣߦ࿎㔍ߒߡ޿ࠆ‫⥃ߚ߹ޕ‬ᐥ㧘ᢎ⢒㧘⎇ⓥߩ޿ߕࠇߦ߽ᤨ㑆ࠍ⾌߿ߔߚ߼㧘⎇ⓥߦචಽߥᤨ㑆߇޽ࠆߣߪ⸒޿㔍޿‫ޕ‬੹ᓟߩዷᦸ㜞㦂ൻߥࠄ߮ߦ↢ᵴ᭽ᑼߩ᰷☨ൻߦ઻޿㧘๭ๆེ∔ᖚߪჇടߩ৻ㅜࠍㄡߞߡ޿ࠆ‫∛ߩࠇߙࠇߘޕ‬᳇ߩࡔࠞ࠾࠭ࡓࠍേ‛ታ㛎㧘⥃ᐥ⎇ⓥࠍㅢߓߡ⸃᣿ߒ㧘ᴦ≮ߦᔕ↪ߒߡ޿ߊߎߣ߇㊀ⷐߢ޽ࠆ‫੹ޕ‬ᓟ㧘๭ๆེ∔ᖚߩಽ㊁ߦ߅޿ߡ⚦⢩ᱫߥࠄ߮ߦ⚦⢩ᄌᕈ㧔ࠕࡐ࠻࡯ࠪࠬ㧘ࠝ࡯࠻ࡈࠔࠫ࡯╬㧕㧘⚦⢩ࠍౣ↢ߔࠆౣ㧙㧙↢කቇߥߤ߇߹ߔ߹ߔ㊀ⷐߥ⎇ⓥ࠹࡯ࡑߣߥࠆߎߣ߇੍ᗐߐࠇࠆ‫ޕ‬ᓥߞߡᚒ‫ߩߎߪޘ‬ὐࠍචಽ⹺⼂ߒ㧘⚦⢩↢‛ቇ⊛ᚻᴺࠍ㚟૶ߒᣂߒ޿࠺ࡃࠗࠬࠍዉ౉ߒߡ㧘ߐࠄߦᵴ⊒ߥ⎇ⓥᵴേࠍⴕߞߡ޿߆ߥߊߡߪߥ
ࠄߥ޿ߣ⠨߃ࠆ‫ޕ‬㧙㧙㧔3㧕කቇ♽୶ℂ࡮␠ળකቇಽ㊁1㧚⎇ⓥߩ᭎ⷐ
ߎࠇ߹ߢߣห᭽㧘ౣ↢ක⑼ቇࠍ฽߻කቇ࡮ක≮ో⥸ߦ㑐ߔࠆ↢๮୶ℂߦ㑐ߔࠆ⻉໧㗴ࠍ⠨ⓥߒ㧘࡜ࠗࡈࠨࠗࠛࡦࠬ࡮ක≮࡮⋴⼔ߩၮ␆⊛෸߮ᔕ↪⊛ߥ⻉໧㗴ߦኻᔕߢ߈ࠆ↢๮୶ℂᢎ⢒ࠍዷ㐿ߢ߈ࠆࠃ߁㧘ᧄ㇌ߦ߅ߌࠆ Bioethics ߩ⏕┙ࠍ⋡ᜰߒߡ⎇ⓥᵴേࠍ⛮⛯ߒߡ߈ߚ‫ߩߘޕ‬ၮᧄℂᔨߪ㧘ᐔᚑ 14㧔2002㧕ᐕ 4᦬㧘ጘ㒂ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼ߦౣ↢ක⑼ቇኾ᡹߇ߢ߈㧘ᒰಽ㊁߇㐿⸳ߐࠇߡ߆ࠄ㧘⃻࿷߽㚂የ৻⽾ߒߡ޿ࠆ‫ޕ‬ᒰᦼߩ⎇ⓥᵴേߪ㧘೨ᦼ߆ࠄᒁ߈⛯޿ߡ㧘‫ߦ∛⚻␹ޟ‬ଥࠆၮ␆ౣ↢⎇ⓥߣ⸻ᢿᴦ≮㐿⊒ߩⷞὐߦ㑐ߔࠆ⎇ⓥ‫ޠ‬㧘ߐࠄߦක੐ᴺቇ⊛⷗࿾߆ࠄ‫ޟ‬කᏧߩ⟵ോߣⵙ㊂㧔ᮭ㧕ߦ㑐ߔࠆ⎇ⓥ‫␠ߣޠ‬ળቇ⊛⷗࿾߆ࠄ‫଻ޟ‬㒾⠪ᯏ⢻ᒝൻߣක≮೙ᐲᡷ㕟ߦ㑐ߔࠆ⎇ⓥ‫ࠍޠ‬ᣂߚߦ⸘↹ߒ㧘ᄢ߈ߊ࠹࡯ࡑࠍ 3 ߟߦಽߌߡ୶ℂ⊛࡮ᴺ⊛࡮␠ળ⊛໧㗴㧔ELSI㧦Ethical, Legal and Social Issues㧕ߣߒߡ໧㗴⟲ࠍᢛℂߒߥ߇ࠄ⎇ⓥᵴേࠍⴕߞߚ‫ ࠄࠇߎޕ‬3 ߟߩ࠹࡯ࡑߦߟ޿ߡߩ⎇ⓥߦ౒ㅢߔࠆߎߣߪ㧘‫ޟ‬୘ߩක≮‫␠⥸৻ޟߣޠ‬ળ‫ࠬࡦ࡜ࡃߩߣޠ‬ࠍᅤ૗ߦ଻ߜߟߟ↢๮୶ℂߩ໧㗴ࠍ⸃᳿ߦะࠊߖࠆ߆ߣ޿߁ߎߣߦዧ߈ࠆ‫ޕ‬ౣ↢ක≮ࠍ዁᧪ࠝ࡯࠳࡯ࡔࠗ
࠼ක≮ߦ߹ߢ⊒ዷߐߖࠆߚ߼ߦߪ㧘hES ⚦⢩߿ iPS ⚦⢩ߥߤߩవ┵ᛛⴚ╬ߩකቇ⊛೑↪߇ਇนᰳߢ޽ࠆ‫ޕ‬ߒ߆ߒ㧘⃻⁁ߪࠟࠗ࠼࡜ࠗࡦ╬ߩᡷ⸓߇ㅴ߼ࠄࠇߡ߈ߡ޿ࠆ߽ߩߩ㧘᰷☨ߣᲧߒߡᦝߥࠆ〯ߺㄟࠎߛ⼏⺰߇ᔅⷐߢ޽ࠆ‫ߚ߹ޕ‬㧘‫ޟ‬කᏧߩ⟵ോߣⵙ㊂㧔ᮭ㧕ߦ㑐ߔࠆ⎇ⓥ‫଻ޟߣޠ‬㒾⠪ᯏ⢻ᒝൻߣක≮೙ᐲᡷ㕟ߦ㑐ߔࠆ⎇ⓥ‫ߩޠ‬ฦ⎇ⓥ߆ࠄ߽㧘ᖚ⠪㧔ⵍ㛎⠪㧕ߩ⥄Ꮖ᳿ቯߩၮᧄේೣ߇ၷᜬߐࠇ⛯ߌࠄࠇࠆߚ߼ߦߪ㧘࠮࡯ࡈ࠹ࠖ࡯ࡀ࠶࠻ߣߒߡߩක≮೙ᐲ࡮කቇ⎇ⓥ૕೙ߩᩮᐙࠍ᭴▽ߒ㧘␠ળ⊛ߥᗧᕁ᳿ቯ߇ὑߐࠇࠆ࿯ფࠍ㉯ᚑߔࠆᔅⷐ߇޽ࠆ‫ޕ‬ᒰಽ㊁ߢߪ㧘ߎߩὐࠍਥᒛߔࠆߚ߼ߦ⛮⛯ߒߡ⪺૞࡮⺰ᢥ╬ࠍㅢߓߡ␠ળߦ⊒ାߒߡ޿ࠆ‫ߡߒߣ࠼࡯ࡢ࡯ࠠޕ‬㧘␠ળⴕὑⷙ▸ߩᒻᚑࠍឝߍ㧘⍦⋫ὐࠍ⼏⺰ᜰ៰ߒߟߟ␠ળߩᚑᾫᐲวߣᴺ೙ᐲ
╬ߩ␠ળࠪࠬ࠹ࡓ߇⺞๺ߢ߈ࠆࠃ߁㧘੹ᓟ߽࿖㓙␠ળߩേะߦᵈ⋡ߒߥ߇ࠄ⛮⛯ߒߡ⎇ⓥࠍㆀⴕߒߡ޿ߊ‫ޕ‬
2㧚ฬ★
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㦭↰ᢘ⟵
⼱ญᵏᒄ

Yukiyoshi Tsukata
Yasuhiro Taniguchi

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕
ߥߒ⪺ᦠ㧔᰷ᢥ㧕
ߥߒ✚⺑㧔๺ᢥ㧕
1㧕 ⼱ญᵏᒄ㧚ታ㛎⊛ක≮ߩታᣉߦะߌߚ↢๮୶ℂቇ⊛ᬌ⸛㧙࡝ࠬࠢࠦࡒࡘ࠾ࠤ࡯࡚ࠪࡦߩⷞὐ߆ࠄ㧙㧘␠ળක≮⎇ⓥ 2007 ᐕ㧧5 Ꮞ㧦27㧙35㧚
✚⺑㧔᰷ᢥ㧕
ߥߒේ⪺㧔๺ᢥ㧕
1㧕 ⼱ญᵏᒄ㧚ࡃࠗࠝࠛࠪ࠶ࠢࠬߦ߅ߌࠆ␠ળ⊛ᗧᕁ᳿ቯⷐ࿃ߩേะ㧘␠ળක≮⎇ⓥ 2006 ᐕ㧧4 Ꮞ㧦11㧙17㧚
2㧕 ⼱ญᵏᒄ㧘㦭↰ᢘ⟵㧚HIV ᗵᨴ∝ߣ౏⊛ක≮଻㒾೙ᐲ㧙ක≮⾗Ḯߩ㈩ಽ߆ࠄߩⷞὐ㧙㧘The Journal of AIDS
Research(ᣣᧄࠛࠗ࠭ቇળ⹹) 2006 ᐕ㧧8 Ꮞ㧦140㧙145㧚
3㧕 ⼱ญᵏᒄ㧚ක≮⚻༡ਥ૕ߦ߅ߌࠆࡑࡀࠫࡔࡦ࠻୶ℂߩᔅⷐᕈ㧙ડᬺᵴേ߆ࠄߩ␜ໂ㧙㧘␠ળක≮⎇ⓥ 2007
ᐕ㧧5 Ꮞ㧦11㧙20㧚
4㧕 ⼱ญᵏᒄ㧚଻㒾⠪ᯏ⢻ᒝൻߣක≮೙ᐲᡷ㕟, ␠ળක≮⎇ⓥ 2008 ᐕ㧧6 Ꮞ㧦5㧙12㧚ේ⪺㧔᰷ᢥ㧕
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4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ
1㧕┹੎⊛⾗㊄1㧕 ⎇ⓥઍ⴫⠪㧦⼱ญᵏᒄ㧘⎇ⓥಽᜂ⠪㧦㦭↰ᢘ⟵㧧ጘ㒂ᄢቇᵴᕈൻ⎇ⓥ⾌㧦ක≮⚻༡ਥ૕ߦ߅ߌࠆ⚻ᷣ୶ℂߩ᭴▽ߦะߌߚ⎇ⓥ㧧ᐔᚑ 18 ᐕᐲ㧧377 ජ౞2㧕 ⎇ⓥઍ⴫⠪㧦㦭↰ᢘ⟵㧘⎇ⓥಽᜂ⠪㧦⼱ญᵏᒄ㧧ጘ㒂ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼ߩ⎇ⓥᵴᕈൻ(ක)ߩߚ

㧙㧙߼ߩᡰេ੐ᬺ(ࡊࡠࠫࠚࠢ࠻‫ߩ♽⚻␹ޟ‬ၮ␆⎇ⓥߣౣ↢⎇ⓥߣߘߩᔕ↪ߦၮߠߊ␹⚻∛⸻ᢿᴦ≮㐿⊒‫)ޠ‬㧦ᣂߒ޿ታ㛎⊛ක≮ࠍㆡᱜߦታᣉߔࠆߚ߼ߩ↢๮୶ℂቇ⊛ᬌ⸛㧙␹⚻∛ߦଥࠆၮ␆ౣ↢⎇ⓥߣ⸻ᢿᴦ≮㐿⊒߆ࠄߩⷞὐ㧙㧧ᐔᚑ 18 ᐕᐲ㧧200 ජ౞3㧕 ⎇ⓥઍ⴫⠪㧦㦭↰ᢘ⟵㧘⎇ⓥಽᜂ⠪㧦⼱ญᵏᒄ㧧⽷࿅ᴺੱ߇ࠎ㓸ቇ⊛ᴦ≮⎇ⓥ⽷࿅⎇ⓥഥᚑ㊄㧦߇ࠎ㓸ቇ⊛ᴦ≮૕೙ߩᢛ஻ߣ᜛లߦ㑐ߔࠆ⎇ⓥ㧙↢๮୶ℂ࡮␠ળකቇߩⷞὐ߆ࠄ㧙㧧ᐔᚑ 20 ᐕᐲ㧧
1,000 ජ౞2㧕ฃ⸤⎇ⓥߥߒ
3㧕౒ห⎇ⓥߥߒ
5㧚⊒᣿࡮․⸵಴㗿⁁ᴫߥߒ
6㧚ቇળᵴേ
1㧕ቇળᓎຬ㦭↰ᢘ⟵㧦
1㧕 ᣣᧄ␠ળක≮ቇળℂ੐(㨪⃻࿷)2㧕 ᣣᧄౣ↢ක≮ቇળ⹏⼏ຬ(㨪⃻࿷)3㧕 ᣣᧄ⒖ᬀቇળ⹏⼏ຬ(㨪⃻࿷)4㧕 ᣣᧄ↢๮୶ℂቇળ⹏⼏ຬ(㨪⃻࿷)5㧕 ᣣᧄ DNA ᄙဳቇળ⹏⼏ຬ(ᐔᚑ 18 ᐕ 11 ᦬㨪⃻࿷)2㧕ቇળ㐿௅㦭↰ᢘ⟵㧦
1㧕 ᣣᧄ␠ળක≮ቇળ╙ 7 ࿁ቇⴚᄢળ(ᐔᚑ 18 ᐕ 10 ᦬㧘ᑧጟ)
3㧕ቇⴚ㔀⹹Ⴆ↰ᢘ⟵㧦1㧕 ౣ↢ක≮㧙ᣣᧄౣ↢ක≮ቇળ⹹㧧✬㓸หੱ(㨪⃻࿷)7㧚ቇળ᜗ᓙ⻠Ṷ㧘᜗ᓙࠪࡦࡐࠫࠬ࠻㧘ᐳ㐳㦭↰ᢘ⟵㧦
1㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᖱႎ୶ℂߣ⥃ᐥ∉ቇ⎇ⓥ‫ޠ‬Ṷ⠪)2㧕 ╙ 70 ࿁⸥ᔨᣣᧄᓴⅣེቇળ✚ળ࡮ቇⴚ㓸ળ(ᐔᚑ 18 ᐕ 3 ᦬㧘ฬฎደ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᖱႎ୶ℂߣ⥃ᐥ∉ቇ⎇ⓥ‫ޠ‬ᐳ㐳)
3㧕 ╙ 31 ࿁ᮮᵿᏒ┙ᄢቇකቇળ࡮╙ 40 ࿁୾ㅴળวห✚ળ(ᐔᚑ 18 ᐕ 4 ᦬㧘ᮮᵿ㧘․೎⻠Ṷ‫ޟ‬ක≮ߩ㒢⇇ߣᖚ⠪ߩᦼᓙࠍ߼ߋࠆᴺ⊛໧㗴‫ޠ‬Ṷ⠪)
4㧕 ╙ 21 ࿁කቇᢎ⢒࠮ࡒ࠽࡯‫ޟ‬㔚ሶࠞ࡞࠹ߣකቇᢎ⢒(╙ 2 ࿁)㧙⸻≮㍳⸥タߩᢎ⢒㧙‫(ޠ‬ᐔᚑ 18 ᐕ 8 ᦬㧘ጘ㒂㧘․೎⻠Ṷ‫ޟ‬ቇ↢ߩ⸻≮㍳⸥タߩᜰዉ࡮⋙ᩏߪߤߩࠃ߁ߦⴕ߁߆‫ޠ‬Ṷ⠪)
5㧕 ᣣᧄ␠ળක≮ቇળ╙ 7 ࿁ቇⴚᄢળ(ᐔᚑ 18 ᐕ 10 ᦬㧘ᑧጟ㧘ᢎ⢒⻠Ṷ‫ޟ‬ᓟㆮ∝ࠍ߼ߋࠆ⻉⋧ߦߟ޿ߡ
㧙PTSD ᳃੐⸷⸩ࠍਛᔃߦߒߡ‫ޠ‬Ṷ⠪)
6㧕 ╙ 19 ࿁ᣣᧄ↢๮୶ℂቇળᐕᰴᄢળ(ᐔᚑ 19 ᐕ 11 ᦬㧘᧲੩㧘࠮࠶࡚ࠪࡦ‫ޟ‬ක≮ߣ⚻ᷣ‫ޠ‬ᐳ㐳)7㧕 ᐔᚑ 20 ᐕᐲᣣᧄ㆙㓒ක≮ቇળቇⴚᄢળ(ᐔᚑ 20 ᐕ 10 ᦬㧘ጘ㒂㧘ࠪࡦࡐࠫ࠙ࡓ‫ޟ‬㆙㓒ක≮ߩࠟࠗ࠼࡜ࠗࡦ㧙ߘߩ୶ℂ⊛␠ળ⊛໧㗴㧙‫ޠ‬Ṷ⠪)8㧕 ᣣᧄ␠ળක≮ቇળ╙ 9 ࿁ቇⴚᄢળ(ᐔᚑ 20 ᐕ 10 ᦬㧘ᑧጟ㧘ࠪࡦࡐࠫ࠙ࡓ‫޿ߒߐ߿ߦੱޟ‬ක≮ߣ࿾ၞ⑔␩ࠍ߼ߑߒߡ‫)࡯࠲࡯ࡀࠖ࠺࡯ࠦޠ‬8㧚ቇⴚ⾨╬ߩฃ⾨⁁ᴫ
ߥߒ

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1㧕 ᣣᧄㆮવሶ⸻≮ቇળ୶ℂ໧㗴ᆔຬળᆔຬ(㨪⃻࿷)2㧕 ᣣᧄ⒖ᬀቇળ୶ℂᆔຬળᆔຬ(㨪⃻࿷)3㧕 ⤟࡮⤟ፉ⒖ᬀ⎇ⓥળ਎⹤ੱ(㨪⃻࿷)4㧕 ㄭ⇰⤟⒖ᬀᬌ⸛ળ਎⹤ੱ(㨪⃻࿷)5㧕 ੩ㇺᄢቇౣ↢ක⑼ቇ⎇ⓥᚲකߩ୶ℂᆔຬળᆔຬ(㨪⃻࿷)6㧕 ⽷࿅ᴺੱᨵ㆏ᢛᓳ⎇ୃ⹜㛎⽷࿅࿖ኅ⹜㛎ᐙ੐ᆔຬ(㨪⃻࿷)7㧕 ⽷࿅ᴺੱ߇ࠎ㓸ቇ⊛ᴦ≮⎇ⓥ⽷࿅⹏⼏ຬ࡮୶ℂᆔຬળᆔຬ㐳(㨪⃻࿷)8㧕 ṑ⾐ක⑼ᄢቇേ‛↢๮⑼ቇ⎇ⓥ୶ℂᆔຬળᆔຬ(㨪⃻࿷)9㧕 ⁛┙ⴕ᡽ᴺੱ↥ᬺᛛⴚ✚ว⎇ⓥᚲකᎿቇᔕ↪ታ㛎୶ℂᆔຬળᆔຬ೽ᆔຬ㐳(㨪⃻࿷)10㧕 ጘ㒂⋵଻ஜᚲ╬୶ℂክᩏᆔຬળᆔຬ㐳(㨪⃻࿷)11㧕 ᧲ᵗ≮ᴺ⎇ୃ⹜㛎⽷࿅╙ 8 ᦼ޽ࠎ៺ࡑ࠶ࠨ࡯ࠫᜰ࿶Ꮷ‫ࠅߪޔ‬Ꮷ෸߮߈ࠀ߁Ꮷ⹜㛎ᆔຬ(ᐔᚑ 18 ᐕ 7᦬㨪⃻࿷)
12㧕 ᣣᧄ DNA ᄙဳቇળ୶ℂᆔຬળᆔຬ㐳(ᐔᚑ 18 ᐕ 11 ᦬㨪⃻࿷)13㧕 ጘ㒂⋵කᏧળᴦ㛎ክᩏᆔຬળᆔຬ(ᐔᚑ 19 ᐕ 4 ᦬㨪⃻࿷)
14㧕 ጘ㒂᧲ᵗකቇ⎇ⓥળ਎⹤ੱ(ᐔᚑ 19 ᐕ 12 ᦬㨪⃻࿷)15㧕 ᣣᧄᚻߩᄖ⑼ቇળ୶ℂᆔຬળࠕ࠼ࡃࠗࠩ࡯(ᐔᚑ 20 ᐕ 3 ᦬㨪⃻࿷)16㧕 ᣣᧄᢛᒻᄖ⑼ቇળ⣄ᬁౝⷞ㏜ਅᚻⴚ࡮ᛛⴚ⹺ቯ೙ᐲᆔຬળᆔຬ(ᐔᚑ 20 ᐕ 9 ᦬㨪⃻࿷)17㧕 ⤟࡮⤟ፉ⒖ᬀ⎇ⓥળ୶ℂᆔຬળᆔຬ(ᐔᚑ 20 ᐕ 12 ᦬㨪⃻࿷)10㧚ႎ๔ᦠ
1㧕 ⼱ญᵏᒄ㧘㦭↰ᢘ⟵㧦ක≮⚻༡ਥ૕ߦ߅ߌࠆ⚻ᷣ୶ℂߩ᭴▽ߦะߌߚ⎇ⓥ㧦ጘ㒂ᄢቇᵴᕈൻ⎇ⓥ⾌ႎ๔ᦠ㧦1㧙2(2007 ᐕ 12 ᦬)
2㧕 㦭↰ᢘ⟵㧘⼱ญᵏᒄ㧦␹⚻∛ߦଥࠆၮ␆ౣ↢⎇ⓥߣ⸻ᢿᴦ≮㐿⊒ࠍ౞Ṗߦታᣉߔࠆߚ߼ߩ↢๮୶ℂቇ⊛ᬌ⸛㧙࡝ࠬࠢࠦࡒࡘ࠾ࠤ࡯࡚ࠪࡦߩⷞὐ߆ࠄ㧙㧦╙ 2 ࿁ጘ㒂ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼࡮කቇㇱ࡮㒝ዻ∛㒮ቇⴚ⎇ⓥ⊒⴫ળႎ๔㓸㧦66(2007 ᐕ 3 ᦬)
11㧚ႎ㆏1㧕 㦭↰ᢘ⟵㧦ᴦ≮ᜎุ଀ߢਥᴦක߇ᢌ⸷(ࠦࡔࡦ࠻)㧦ᣣ⚻ࡔ࠺ࠖࠞ࡞(2006 ᐕ 3 ᦬ 10 ᣣ)
2㧕 㦭↰ᢘ⟵㧦ࡅ࠻⢦㧘ES ⚦⢩ࠍ߼ߋࠆ↢๮୶ℂ(ࠦࡔࡦ࠻)㧦ㅳೀකቇ⇇ᣂ⡞(2006 ᐕ 4 ᦬ 3 ᣣ)
12㧚⥄Ꮖ⹏ଔ
⹏ଔ᭎ⷐߦ␜ߒߚᒰಽ㊁ߩ⋡ᮡߦᴪߞߡ㧘ᢎቶຬฦ⥄߇ฦ‫⎇ߩޘ‬ⓥ࠹࡯ࡑߦᴪߞߡ⎇ⓥࠍታᣉߒߚ‫ޕ‬‫⚻␹ޟ‬∛ߦଥࠆၮ␆ౣ↢⎇ⓥߣ⸻ᢿᴦ≮㐿⊒ߩⷞὐߦ㑐ߔࠆ⎇ⓥ‫ߪߡ޿ߟߦޠ‬㧘ቇౝࡊࡠࠫࠚࠢ࠻ߦෳടߒ㧘⎇ⓥࠍⴕߞߚ‫⎇ޕ‬ⓥߩᡰេߣߒߡ㧘ጘ㒂ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼ߩ⎇ⓥᵴᕈൻ㧔ක㧕ߩߚ߼ߩᡰេ੐ᬺ
㧔ࡊࡠࠫࠚࠢ࠻‫ߩ♽⚻␹ޟ‬ၮ␆⎇ⓥߣౣ↢⎇ⓥߣߘߩᔕ↪ߦၮߠߊ␹⚻∛⸻ᢿᴦ≮㐿⊒‫ޠ‬㧕ߩၮ㊄߆ࠄᐔ
ᚑ 18 ᐕᐲߦ 200 ජ౞ߩഥᚑࠍฃߌߚ‫ߚ߹ޕ‬㧘‫ޟ‬කᏧߩ⟵ോߣⵙ㊂㧔ᮭ㧕ߦ㑐ߔࠆ⎇ⓥ‫ߪߡ޿ߟߦޠ‬㧘ቇౝㆇ༡⾌㧔⻠ᐳ⾌㧕ࠍ↪޿ߡ⎇ⓥࠍⴕ޿㧘කቇㇱᢎ⢒㧔࠹ࡘ࠻࡯࡝ࠕ࡞↢๮୶ℂ࡮ᴺකቇࠦ࡯ࠬ㧕ߦౕ૕⊛ߥ੐଀ឭ␜ࠍⴕ޿㧘ㆶరߒߡ޿ࠆ‫ߦࠄߐޕ‬㧘‫଻ޟ‬㒾⠪ᯏ⢻ᒝൻߣක≮೙ᐲᡷ㕟ߦ㑐ߔࠆ⎇ⓥ‫ߦޠ‬㑐ߒߡߪ㧘ಽ㊁ౝ౒ห⎇ⓥࠍⴕ޿㧘⎇ⓥഥᚑߣߒߡ㧘ጘ㒂ᄢቇᵴᕈൻ⎇ⓥ⾌㧦ක≮⚻༡ਥ૕ߦ߅ߌࠆ⚻ᷣ୶
ℂߩ᭴▽ߦะߌߚ⎇ⓥ㧔ᐔᚑ 18 ᐕᐲ㧧377 ජ౞㧕ߣߒߡᡰេࠍฃߌߚ‫ޕ‬ᒰಽ㊁ߩ┙᩺ߒߚ⎇ⓥ⸘↹߇ክᩏࠍฃߌ⎇ⓥߩഥᚑࠍฃߌߡ޿ࠆߎߣ߆ࠄ㧘␠ળ⊛ߥᤨᵹߦᴪߞߚౝኈߢ޽ࠅ㧘␠ળߩ࠾࡯࠭߆ࠄㅺ⣕ߔࠆ߽ߩߢߪߥ޿‫⹏ߡߞࠃޕ‬ଔߐࠇߚ߽ߩߣ್ᢿߔࠆ‫ޕ‬⃻⁁ߩ໧㗴ὐ෸߮ߘߩኻᔕ╷ᒰಽ㊁߇ⴕߞߚ⎇ⓥߪ㧘ᢎቶຬߩฦ಴りಽ㊁ࠍ෻ᤋߒ㧘ਥߦ␠ળ⑼ቇ߆ࠄߩⷞὐࠍએߞߡ㧘↢๮୶ℂߦ㑐ߔࠆ㗔ၞߩ⻉໧㗴ࠍ⪺૞࡮⺰ᢥᒻᑼߢ␠ળߦ⊒ାߒߡ޿ࠆ‫ߒ߆ߒޕ‬㧘ታ㓙ߦක≮ឭଏࠍⴕ߁ᯏ㑐ߦᚲዻߔࠆ৻ኾ㐷ಽ㊁ߣߒߡ㧘ࠃࠅౕ૕⊛ߦ㧘ࠃࠅታലᕈࠍ઻ߞߡᚲዻᯏ㑐ౝߢ⍮⼂ߩ౒᦭ൻ߇࿑ࠄࠇࠆ
ࠃ߁ߥᓎഀ߇ᨐߚߖߡ޿ࠆ߆ߣ⠨߃ߚ႐ว㧘ᄙዋߩᡷༀߔߴ߈ὐ߽᜼ߍࠄࠇࠆ‫ߪߢ⁁⃻ޕ‬ቢోߦߪ໧㗴ߦኻಣߢ߈ߡ޿ߥ޿‫ޕ‬ᯏ㑐ౝߩ․ᱶߥಽ㊁ߣߩ૏⟎ߠߌߦ↞߃ࠆߎߣߥߊ㧘ቇౝᄖߢࠦࡒࡘ࠾ࠤ࡯࡚ࠪ
ࡦࠍขࠅߟߟ㧘↢๮୶ℂߦ㑐ߔࠆࠦࡦࠨ࡞࠹࡯࡚ࠪࡦࠍⴕ߁ߥߤߩ໧㗴ᗧ⼂ߩ౒᦭ൻࠍ࿑ࠆߎߣ߇⢄ⷐ㧙㧙ߢ޽ࠆ‫ߩߘޕ‬ኻ╷ߣߒߡ㧘ቇౝߩ Faculty Development ߦⓍᭂ⊛ߦෳടߒ㧘ᖱႎࠍ⊒⸒ߔࠆߎߣ߿㧘ઁ
ߩಽ㊁ߣ౒หߢ࠮ࡒ࠽࡯ࠍⴕ߁ߥߤߩⓍᭂ⊛ߥᵴേࠍዷ㐿ߔࠆᔅⷐ߇޽ࠆ‫ߚ߹ޕ‬㧘කቇ⎇ⓥ╬୶ℂክᩏ
ᆔຬળߦ߅ߌࠆክᩏㆊ⒟ߦ߅޿ߡ㧘⎇ⓥ⠪ߦኻߔࠆ⛮⛯ߒߚ↢๮୶ℂߦଥࠆᖱႎߩឭଏߣᢎ⢒໪⊒ࠍⴕ߁ᔅⷐ߽޽ࠆ‫ޕ‬੹ᓟߩዷᦸ೨࿁ߩᧄ⥄Ꮖὐᬌ⹏ଔႎ๔ᦠߩ૞ᚑᤨߦߪ㧘iPS ⚦⢩᮸┙ߩႎ๔ߪߥ߆ߞߚ‫ࠄ߆ࠇߎޕ‬వ߽ක≮࡮࡜ࠗࡈࠨࠗࠛࡦࠬߩᦝߥࠆㅴዷߦ઻޿㧘ᣂߒ޿⍮⷗ߣߘࠇߦઃ㓐ߔࠆ⚻㛎ߒߚߎߣߩߥ޿ࠃ߁ߥ↢๮୶ℂ໧㗴ߦ⋥㕙ߔࠆߎߣ߇੍᷹ߐࠇࠆ‫ޕ‬ᒰಽ㊁ߣߒߡ⫾Ⓧߒߡ߈ߚ⍮⼂ࠍᧄോᩞߣ␠ળߦㆶరߢ߈ࠆࠃ߁㧘ߎࠇ߹ߢߣห᭽ߦ⎇ⓥࠍ⛮⛯ߒ㧘ࡃࠗࠝࠛࠪ࠶ࠢࠬࠍ⎇ⓥߔࠆኾ㐷⊛ߥᢎቶߣߒߡ㧘⺰ᢥ࡮⪺૞ࠍㅢߓߡ␠ળߦ⊒ାࠍ⛯ߌߡ޿ߊ‫ߚ߹ޕ‬㧘ቇㇱᢎ⢒߅ࠃ߮ᄢቇ㒮ᢎ⢒ߩਛߦᦨᣂ࠻ࡇ࠶ࠢࠍណࠅ౉ࠇ㧘↢๮୶
ℂߦ♖ㅢߒߚੱ᧚ࠍ㙃ᚑߔࠆߎߣ߽⛮⛯ߒߡⴕ߁‫ߪߦࠄߐޕ‬㧘ᣣᧄߦ߅ߌࠆකቇ⎇ⓥ୶ℂክᩏᆔຬળߩ
ᦝߥࠆ⾰ߩะ਄ࠍ⋡ᜰߒߡ㧘ઁߩකቇㇱ࡮ක⑼ᄢቇߣ✕ኒߦㅪ⛊ࠍขߞߡ޿ߊߎߣ߽ⷞ㊁ߦ޿ࠇߡ޿ࠆ‫ޕ‬ⴕ᡽߿৻⥸␠ળࠍᏎ߈ㄟࠎߛో࿖⊛ⷞ㊁ߢߩ↢๮୶ℂߦ㑐ߔࠆ⎇ⓥ߅ࠃ߮ᢎ⢒ᵴേ߇ዷ㐿ߐࠇࠆࠃ߁㧘ߘߩ৻⠢ࠍᜂ߁ㇱ㐷ߣߒߡߩ␠ળ⊛⽿છ߇ᨐߚߖࠆࠃ߁ദജߒߡ޿ߊ‫ޕ‬㧙㧙

7. ቇ૏ߩ᝼ਈ⁁ᴫߣ⎇ⓥᚑᨐ
ౣ↢ක⑼ቇኾ᡹ߦ߅޿ߡඳ჻㧔ౣ↢ක⑼ቇ㧕ߩቇ૏ࠍ᝼ਈߒߚᢙߪ㧘ᰴ⴫ߩߣ߅ࠅߢ޽ࠆ‫ޕ‬඙ಽ

ᐔᚑ 16 ᐕᐲᐔᚑ 17 ᐕᐲᐔᚑ 18 ᐕᐲᐔᚑ 19 ᐕᐲ

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ᐔᚑ 15 ᐕᐲᐔᚑ 16 ᐕᐲᐔᚑ 17 ᐕᐲᐔᚑ 18 ᐕᐲᐔᚑ 19 ᐕᐲᐔᚑ 20 ᐕᐲ

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ᐔᚑ 15 ᐕᐲᐔᚑ 16 ᐕᐲᐔᚑ 17 ᐕᐲᐔᚑ 18 ᐕᐲᐔᚑ 19 ᐕᐲᐔᚑ 20 ᐕᐲ

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9. ⥄Ꮖ⹏ଔ࡮⺖㗴ߣዷᦸԘᢎຬ⚵❱ߩᒝൻߣ⥄Ꮖ⹏ଔߩᔀᐩ
ᐔᚑ 16 ᐕ 6 ᦬ߦᣂ▽ߐࠇߚකቇㇱ࡮㒝ዻ∛㒮߳ߩ⒖ォߦ઻޿㧘ౣ↢ක⑼ቇኾ᡹ߩోᢎຬ߇ห৻

ࡈࡠࠕ࡯ߦ㓸߹ࠅ㧘ኒធߥදജ߇ታᣉน⢻ߥᘒ൓߽ߢ߈ߚ‫৻ޕ‬ᣇ㧘කቇ♽⎇ⓥ⑼ߦ߅ߌࠆᢎຬᢙߩ
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2㧕 ᄢቇ㒮ቇ↢ߩ⎇ⓥᯏ⢻ߩలታ : ౣ↢ක⑼ቇኾ᡹ߩ⎇ⓥᯏ⢻ߪ߆ߥࠅలታߒߡ߈ߡ߅ࠅ㧘࿖㓙⊛৻ᵹ⹹߳ߩᛩⓂࠍ⋡ᜰߔ‫ޕ‬3㧕 ⎇ⓥ⾌ߩలታ㧘ᄢဳ⸳஻ߩᢛ஻ : ⃻࿷߽ᢥㇱ⑼ቇ⋭㧘ෘ↢ഭ௛⋭╬߆ࠄᄢဳ⎇ⓥ⾌ࠍᓧߡ޿ࠆ
ᢎຬ߽޿ࠆ߇㧘ࠃࠅ৻ጀߩ₪ᓧࠍ⋡ᜰߒ㧘ᄢဳ⸳஻╬ߩలታࠍ࿑ࠆ‫ޕ‬ᐔᚑ 16 ᐕ 6 ᦬ߦකቇㇱ࡮㒝ዻ∛㒮߇⒖ォߒ㧘ᐔᚑ 17 ᐕᐲߦߪ↢๮⑼ቇ᫟߇ᣂ▽ߐࠇࠕࠗ࠰࠻࡯ࡊታ㛎ᣉ⸳㧘േ‛ታ㛎ᣉ⸳ߥߤߩᦨᣂ⸳஻߇ᢛߞߚᑪ‛߇ቢᚑߒ㧘ᄙߊߩ⎇ⓥ⠪ߦࠃߞߡ೑↪ߐࠇߡ޿ࠆ‫ེ࡮❱⚵ޕ‬ቭᒻ
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ᯏེ࠮ࡦ࠲࡯߇⸳⟎ߐࠇ㧘ዉ౉ߐࠇߚᄢဳᯏེ߇ౣ↢ක⑼ቇ෸߮ක⑼ቇኾ᡹ࠍ໧ࠊߕᄙߊߩ⎇ⓥ⠪߿ᄢቇ㒮↢ߦࠃߞߡᵴ↪ߐࠇߡ޿ࠆ‫ޕ‬Ԛᢎ⢒ᯏ⢻ߩలታ
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