ISN 2014 Special Conference – Program at a Glance
LegendPlenary lecture

Keynote Lecture

BreakSocial Event

Round Table

Poster Session

Young Investigators

Oral session“Dynamic Change of Nanostructure in the Brain in Health and Disease– Cutting Edge of the Technical Innovation –”Saturday, September 20, 2014
12:00

Registration Opens
14:00-14:15 - Opening remarks - Katsuhiko Mikoshiba

14:15 15:15

15:15 17:00(PL1) Opening Lecture
Chair: Tomoaki Shirao
14:15-15:15 - Toshio Ando, Japan
Video imaging of walking myosin V by high-speed atomic force microscopy(S1) Development of new techniques of optical microscopy
Chairs: Rainer Duden & Yuko Sekino
15:15-15:45 - Valentin Nagerl, France - STED imaging of neuronal synapses
15:45-16:15 - Irina Majoul, Germany - Molecules controlling the rearrangement of highly
permeable cell-cell contact interfaces
16:15-16:45 - Johnny Tam, Spain - Cross-Talk-Free Multi-Color STORM
16:45-17:00 - Short talk: L. F. Yoong, Japan - An in vivo time-lapse imaging screen reveals thatatypical myosin regulate growth cone behavior in complex dendritic branching

Sunday, September 21, 2014
09:00 09:45

09:45 10:15(KL1) Keynote Lecture
Chair: Hiroshi Ohnishi
So Iwata, UK - Structure studies on G-protein coupled receptors

Coffee Break10:15 11:30

11:30 13:30(S2) Probe microscopy and NMR
Chairs: Elena Grintsevich & Tatsuo Ushiki
10:15-10:45 - Tatsuo Ushiki, Japan - Scanning ion conductance microscopy and its applications inbiology
10:45-11:15 - Inagaki F., Japan - "Initial phosphorylation step required for FGF receptor activation"
11:15-11:30 - Short talk: K. Takahashi, Japan - Quantitative observation of cultured glia and gliomausing high-resolution acoustic impedance microscope
Break & Poster Session

13:30 14:15(KL2) Keynote Lecture
Chair: Yumiko Saito
Olivier Civelli, USA - Orphan GPCRs and the search for their ligands

14:15 16:00(S3) Molecular signature and dissection of G-protein-coupled receptor
Chair: Peter Penzes
14:15-14:45 - Takuya Kobayashi, Japan - Crystallization of human GPCRs using antibody fragments
14:45-15:15 - Lakshimi A. Devi, USA - Opioid receptor heteromer regulation by endogenous
chaperones
15:15-15:45 - Kazushige Touhara, Japan - Chemosensory receptors and animal behavior
15:45-16:00 - Short talk: Akie Hamamoto, Japan - The intracellular residues which are important
for the selective activation of Gi/o proteins in rat melanin-concentrating hormone

16:00 16:30

16:30 18:30

Coffee Break(S4) Membrane receptors, transporters and synapses
Chairs: Yoshikatsu Kanai & Mica Ohara-Imaizumi
16:30-17:00 - Joseph Schlessinger, USA - Structural basis for KIT receptor tyrosine kinase inhibition
by antibodies targeting the D4 membrane-proximal region
17:00-17:30 - Atsuko Yamashita, Japan - Structure and function of a prokaryotic SLC6 transporter
LeuT - a footing for understanding neurotransmitter transporters
17:30-18:00 - Maria Mittelbrunn, Spain The immune synapse as a platform to facilitate theintercellular transfer of genetic information
18:00-18:30 - Stepane Oliet, France - Surface dynamics of astroglial glutamate transporter GLT-1
shapes excitation

Monday, September 22, 2014
09:00 09:45
09:45 10:00(KL3) Keynote Lecture
Chair: Keiichi Uyemura
Tomoaki Shirao, Japan - Drebrin and its function
Coffee Break10:00 12:00

12:00 14:00(S5) Nanostructure of actin-myosin system
Chairs: Christian Gonzalez-Billault & Shinichi Hisanaga
10:00-10:30 - Elena Grintsevich, USA - Nanoscale remodeling of actin filaments by drebrin A andits implication for regulatory interactions
10:30-11:00 - Phillip R. Gordon, UK - Drebrin function in Neuritogenesis and Cancer
11:00-11:15 - Ryoki Ishikawa, Japan - Properties of the sliding of myosin on actin filaments
decorated with various kinds of actin-binding proteins
11:15- 11:45 - Rainer Duden, Germany - Functional Insights into remodelling of cell-cell contactsby AB5 toxins
11:45-12:00: Short talk: E. Butkevich, Germany - Drebrin-like protein 1 is a novel sarcomere
component which stabilizes actin filaments during muscle contraction

Break & Poster Session

14:00 14:45(YL1) Young Investigator Lecture
Chair: Hiroshi Kiyama
Hideto Takahashi, Canada - Neuronal adhesion complexes inducing CNS synapse development

14:45 15:45

Round Table
Chairs: Itsuki Ajioka & Miwako Kobayashi
Participants: All speakers and the registrants who sign up

15:45 16:00

Coffee Break

16:00 17:45(S6) Dynamic structure of signaling proteins
Chairs: Nobuyuki Takei & Lambright DG
16:00-16:30 - Lambright DG, USA - Structural dynamics of autoregulation in phosphoinositidedependent Arf GTPase exchange factors
16:30-17:00 - Daisuke Kohda, Japan - Structural and dynamic basis for mitochondrial presequence
recognition by Tom20
17:00-17:30 - Taisuke Tomita, Japan - Structure of γ-secletase
17:30-17:45 - Short talk: Shin-ichi Terawaki, Japan - Structural basis for the membrane-targetingof Rac-specific guanine nucleotide exchange factors, Tiam1/2”

17:45 18:45(PL2) Closing Lecture
Chair: Kazuhiro Ikenaka
17:45-18:45 - Katsuhiko Mikoshiba, Japan
IP3 receptors and calcium in health and disease-from crystal structure to in vivo analysis
18:45-18:50 - Closing Remarks - Tomoaki Shirao

19:30-22:00 - Farewell Party