PRODUCTS AND SERVICES
ターゲットリスト

P.1-11キナーゼ蛋白質製品リスト

P.12

キナーゼアッセイキットリスト ～QuickScout Screening Assist® Kits～

P.13

キナーゼプロファイリング・スクリーニングサービスリスト～QuickScout® Custom Profiling & Panel Profiling Series～

P.14

キナーゼプロファイリング・スクリーニングターゲットリスト～Preincubation～

P.15

カイネティクス測定アッセイ ～Phosphosens™～ ターゲットリスト

P.16

キナーゼ蛋白質相互作用解析 ～Residence Timer™～ ターゲットリスト

P.17-18 NanoBRET™ TE Intracellular Kinase キナーゼセルべースアッセイターゲットリスト
P.19

ヒト腫瘍細胞株パネル ～Oncolines™～ 対象ヒト腫瘍細胞株リスト

P.20

タンパク質相互作用のセルベースアッセイ 安定発現細胞株リスト

P.21

結晶化構造解析サービスターゲットリスト FastLane™ Structures～Premium～

P.22-23 結晶化構造解析サービスターゲットリスト FastLane™ Structures～Standard～キナーゼ蛋白質製品リスト※商品詳細は別紙PRODUCT AND SERVICES 1~3ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Tyrosine Kinases
Protein Kinase
ABL(ABL1)
ABL(ABL1) [E255K]
ABL(ABL1) [T315I]
ACK(TNK2)
ALK
ALK [C1156Y]
ALK [D1203N]
ALK [F1174L]
ALK [F1174/G1202R]
ALK [G1202R]
ALK [G1269A]
ALK [I1171N]
ALK [I1171N/L1198F]
ALK [I1171S]
ALK [I1171T]
ALK [L1196M]
ALK [L1196M/G1202R]
ALK [L1198F]
ALK [L1198F/G1202R]
ALK [R1275Q]
ALK [T1151_L1152insT]
ALK [V1180L]
ARG(ABL2)
AXL
BLK
BMX

BRK(PTK6)BTK

BTK [C481S]

BTK[M437R]

BTK [T316A]
BTK [T474I]
BTK [T474S]
CSK
DDR1
DDR1(SRC treated)
DDR2
EGFR
EGFR [C797S]

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemHIS

ABL(ABL1)

08-001

Full-length2-1130

NP_005148.2

N-terminal His

Insect (sf21)

BTN

BTN-ABL(ABL1)

08-401-20N

Full-length2-1130

NP_005148.2

N-terminal DYKDDDDK

Insect (sf21)

HIS

ABL(ABL1)[E255K]

08-094Full-length2-1130

NP_005148.2

N-terminal His

Insect (sf21)

HIS

ABL(ABL1)[T315I]

08-093Full-length2-1130

NP_005148.2

N-terminal His

Insect (sf21)

BTN

BTN-ABL(ABL1)[T315I]

08-493-20N

Full-length2-1130

NP_005148.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ACK(TNK2)

08-196

Catalytic domain

110-476

NP_005772.3

N-terminal GST

Insect (sf21)

GST

ALK

08-518

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK

08-405-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[C1156Y]

08-530

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[C1156Y]

08-730-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[D1203N]

08-583

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

GST

ALK[F1174L]

08-519Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[F1174L]

08-719-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[F1174/G1202R]

08-568

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[F1174L/G1202R]

08-768-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[G1202R]

08-544

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[G1202R]

08-744-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[G1269A]

08-537

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[G1269A]

08-737-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[I1171N]

08-566

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[I1171N]

08-766-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[I1171N/L1198F]

08-567

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[I1171N/L1198F]

08-767-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[I1171S]

08-569Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[I1171S]

08-769-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[I1171T]

08-590

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[I1171T]

08-790-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[L1196M]

08-529Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[L1196M]

08-429-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[L1196M/G1202R]

08-556

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[L1196M/G1202R]

08-756-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[L1198F]

08-571

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[L1198F]

08-771-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[L1198F/G1202R]

08-584

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

GST

ALK[R1275Q]

08-520

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[R1275Q]

08-720-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ALK[T1151_L1152insT]

08-539Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

GST

ALK[V1180L]

08-570

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal GST

Insect (sf21)

BTN

BTN-ALK[V1180L]

08-770-20N

Cytoplasmic domain

1058-1620

NP_004295.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ARG(ABL2)

08-102Full-length

2-1161

NP_001161708.1

N-terminal GST

Insect (sf21)

GST

AXL

08-107

Cytoplasmic domain464-885

NP_001690.2

N-terminal GST

Insect (sf21)

BTN

BTN-AXL

08-407-20N

Cytoplasmic domain464-885

NP_001690.2

N-terminal DYKDDDDK

Insect (sf21)

GST

BLK

08-164Full-length

1-505

NP_001706.2

N-terminal GST

Insect (sf21)

GST

BMX

08-179Full-length

1-675

NP_001712.1

N-terminal GST

Insect (sf21)

BTN

BTN-BMX

08-479-20N

Full-length

1-675

NP_001712.1

N-terminal DYKDDDDK

Insect (sf21)

GST

BRK(PTK6)

08-165Full-length

2-451

NP_005966.1

N-terminal GST

Insect (sf21)

BTN

BTN-BRK(PTK6)

08-465-20N

Full-length

2-451

NP_005966.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BRK(PTK6)[non-activated]

08-465-23N

Full-length

2-451

NP_005966.1

N-terminal DYKDDDDK

Insect (sf21)

GST

BTK

08-180Full-length

2-659

NP_000052.1

N-terminal GST

Insect (sf21)

BTN

BTN-BTK

08-480-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[non-activated]

08-480-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

GST

BTK[C481S]

08-547Full-length

2-659

NP_000052.1

N-terminal GST

Insect (sf21)

BTN

BTN-BTK[C481S]

08-417-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[C481S][non-activated]

08-417-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

GST

BTK[M437R]

08-805Full-length

2-659

NP_000052.1

N-terminal GST

Insect (sf21)

BTN

BTN-BTK[M437R]

08-705-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[M437R][non-activated]

08-705-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T316A]

08-418-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T316A][non-activated]

08-418-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T474I]

08-419-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T474I][non-activated]

08-419-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T474S]

08-420-20N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-BTK[T474S][non-activated]

08-420-23N

Full-length

2-659

NP_000052.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CSK

08-111

Full-length

1-450

NP_004374.1

N-terminal GST

Insect (sf21)

GST

DDR1

08-113

Cytoplasmic domain

444-876

NP_001945.3

N-terminal GST

Insect (sf21)

BTN

BTN-DDR1

08-432-20N

Cytoplasmic domain

444-876

NP_001945.3

N-terminal DYKDDDDK

Insect (sf21)

GST

DDR1(SRC treated)

08-132

Cytoplasmic domain

444-876

NP_001945.3

N-terminal GST

Insect (sf21)

BTN

BTN-DDR1(SRC treated)

08-732-20N

Cytoplasmic domain

444-876

NP_001945.3

N-terminal DYKDDDDK

Insect (sf21)

GST

DDR2

08-114

Cytoplasmic domain422-855

NP_006173.2

N-terminal GST

Insect (sf21)

BTN

BTN-DDR2

08-414-20N

Cytoplasmic domain422-855

NP_006173.2

N-terminal DYKDDDDK

Insect (sf21)

GST

EGFR

08-115

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR

08-415-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

GST

EGFR[C797S]

08-561

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[C797S]

08-761-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

Page 1

キナーゼ蛋白質製品リスト※商品詳細は別紙PRODUCT AND SERVICES 1~3ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Tyrosine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

EGFR[C797S/L858R]

08-563

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[C797S/L858R]

08-763-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

GST

EGFR[d746-750]

08-527

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[d746-750]

08-427-20N

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

GST

EGFR[d746-750/C797S]

08-564

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[d746-750/C797S]

08-764-20N

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

EGFR [d746-750/T790M]

GST

EGFR[d746-750/T790M]

08-528

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [d746-750/T790M/C797S]

GST

EGFR[d746-750/T790M/C797S]

08-565

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal GST

Insect (sf21)

GST

EGFR[d746-750/T790M/C797S/L858R]

08-811

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [C797S/L858R]
EGFR [d746-750]
EGFR [d746-750/C797S]

EGFR [d746-750/T790M/C797S/L858R]

BTN

BTN-EGFR[d746-750/T790M/C797S/L858R] 08-711-20N

Cytoplasmic domain669-745, 751-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

EGFR [D770_N771insNPG]

GST

EGFR[D770_N771insNPG]

08-553

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [D770_N771insNPG/T790M]

GST

EGFR[D770_N771insNPG/T790M]

08-558

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [L718M/T790M/C797S/L858R]

GST

EGFR[L718M/T790M/C797S/L858R]

08-801

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [L718Q/T790M/C797S/L858R]

GST

EGFR[L718Q/T790M/C797S/L858R]

08-802

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [L718V/T790M/C797S/L858R]

GST

EGFR[L718V/T790M/C797S/L858R]

08-803

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [L747P]

GST

EGFR[L747P]

08-588

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [L792H]

GST

EGFR[L792H]

08-562

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

GST

EGFR[L858R]

08-502

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[L858R]

08-402-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

EGFR [L861Q]

GST

EGFR[L861Q]

08-513

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [N771_P772insH]

GST

EGFR[N771_P772insH]

08-149Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [N771GY]

GST

EGFR[N771GY]

08-110

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EGFR [S768I]

GST

EGFR[S768I]

08-589Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

GST

EGFR[T790M]

08-194

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[T790M]

08-494-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

GST

EGFR[T790M/L858R]

08-510

Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

BTN

BTN-EGFR[T790M/L858R]

08-410-20N

Cytoplasmic domain669-1210

NP_005219.2

N-terminal DYKDDDDK

Insect (sf21)

EGFR [T790M/C797S/L858R]

GST

EGFR[T790M/C797S/L858R]

08-559Cytoplasmic domain669-1210

NP_005219.2

N-terminal GST

Insect (sf21)

EML4-ALK

GST

EML4-ALK

08-516

Fused

1-1059

BAF73611.1

N-terminal GST

Insect (sf21)

EPHA1

GST

EPHA1

08-119Cytoplasmic domain586-976

NP_005223.3

N-terminal GST

Insect (sf21)

GST

EPHA2

08-121

Cytoplasmic domain572-976

NP_004422.2

N-terminal GST

Insect (sf21)

BTN

BTN-EPHA2

08-421-20N

Cytoplasmic domain572-976

NP_004422.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-EPHA2[non-activated]

08-421-23N

Cytoplasmic domain572-976

NP_004422.2

N-terminal DYKDDDDK

Insect (sf21)

EPHA3

GST

EPHA3

08-122

Cytoplasmic domain579-983

NP_005224.2

N-terminal GST

Insect (sf21)

EPHA4

GST

EPHA4

08-123

Cytoplasmic domain586-986

NP_004429.1

N-terminal GST

Insect (sf21)

EPHA5

GST

EPHA5

08-124

Catalytic domain662-948

NP_004430.3

N-terminal GST

Insect (sf21)

EPHA6

GST

EPHA6

08-125

Cytoplasmic domain683-1130

NP_001073917.2

N-terminal GST

Insect (sf21)

EPHA7

GST

EPHA7

08-126

Cytoplasmic domain595-998

NP_004431.1

N-terminal GST

Insect (sf21)

EPHA8

GST

EPHA8

08-127

Catalytic domain

571-924

NP_065387.1

N-terminal GST

Insect (sf21)

EPHB1

GST

EPHB1

08-128

Cytoplasmic domain578-984

NP_004432.1

N-terminal GST

Insect (sf21)

EPHB2

GST

EPHB2

08-129Cytoplasmic domain

581-987

NP_004433.2

N-terminal GST

Insect (sf21)

EPHB3

GST

EPHB3

08-130

Cytoplasmic domain596-998

NP_004434.2

N-terminal GST

Insect (sf21)

EPHB4

GST

EPHB4

08-131

Cytoplasmic domain

577-987

NP_004435.3

N-terminal GST

Insect (sf21)

GST

FAK(PTK2)

08-137

Truncated376-1052

NP_722560.1

N-terminal GST

Insect (sf21)

BTN

BTN-FAK(PTK2)

08-437-20N

Truncated376-1052

NP_722560.1

N-terminal DYKDDDDK

Insect (sf21)

FER

GST

FER

08-139Full-length

1-822

NP_005237.1

N-terminal GST

Insect (sf21)

FES

GST

FES

08-140Full-length1-413, 416-822

NP_001996.1

N-terminal GST

Insect (sf21)

GST

FGFR1

08-133

Cytoplasmic domain398-822

NP_075598.2

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR1

08-435-20N

Cytoplasmic domain398-822

NP_075598.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR1[non-activated]

08-435-23N        Cytoplasmic domain398-822

NP_075598.2

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR1[V561M]

08-536

Cytoplasmic domain398-822

NP_075598.2

N-terminal GST

Insect (sf21)

GST

FGFR2

08-134

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2

08-434-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[non-activated]

08-434-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[C491A]

08-576

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[C491A]

08-903-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[C491A][non-activated]

08-903-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[C491A/V564I]

08-578

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[C491A/V564I]

08-905-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[C491A/V564I][non-activated] 08-905-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[C491A/V564L]

08-579Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[C491A/V564L]

08-906-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[C491A/V564L][non-activated] 08-906-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[E565A]

08-807

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[E565A]

08-907-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[E565A][non-activated]

08-907-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

FGFR2 [K659M]

GST

FGFR2[K659M]

08-817

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

FGFR2 [L617V]

GST

FGFR2[L617V]

08-816

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

FGFR2 [M537I]

GST

FGFR2[M537I]

08-812

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

FGFR2 [M537I/M538L]

GST

FGFR2[M537I/M538L]

08-814

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

FGFR2 [M538L]

GST

FGFR2[M538L]

08-813

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

GST

FGFR2[N549D]

08-808

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[N549D]

08-908-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[N549D][non-activated]

08-908-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[N549H]

08-532

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[N549H]

08-901-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[N549H][non-activated]

08-901-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

EGFR [L858R]

EGFR [T790M]
EGFR [T790M/L858R]

EPHA2

FAK(PTK2)

FGFR1
FGFR1 [V561M]
FGFR2

FGFR2 [C491A]

FGFR2 [C491A/V564I]

FGFR2 [C491A/V564L]

FGFR2 [E565A]

FGFR2 [N549D]FGFR2 [N549H]

Page 2

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Tyrosine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

FGFR2[N549K]

08-809Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[N549K]

08-909-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[N549K][non-activated]

08-909-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[V564F]

08-810

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

GST

FGFR2[V564I]

08-546

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[V564I]

08-902-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[V564I][non-activated]

08-902-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR2[V564L]

08-577

Cytoplasmic domain399-821NP_000132.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR2[V564L]

08-904-20N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FGFR2[V564L][non-activated]

08-904-23N

Cytoplasmic domain399-821NP_000132.3

N-terminal DYKDDDDK

Insect (sf21)

GST

FGFR3

08-135

Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR3

08-433-20N

Cytoplasmic domain

436-806

NP_000133.1

N-terminal DYKDDDDK

Insect (sf21)

FGFR3 [G697C]

GST

FGFR3[G697C]

08-542

Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

FGFR3 [K650E]

GST

FGFR3[K650E]

08-501

Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

FGFR2 [N549K]
FGFR2 [V564F]
FGFR2 [V564I]

FGFR2 [V564L]

FGFR3

FGFR3 [K650M]

GST

FGFR3[K650M]

08-199Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

FGFR3 [V555L]

GST

FGFR3[V555L]

08-548

Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

FGFR3 [V555M]

GST

FGFR3[V555M]

08-543

Cytoplasmic domain

436-806

NP_000133.1

N-terminal GST

Insect (sf21)

GST

FGFR4

08-136

Cytoplasmic domain

460-802

NP_002002.3

N-terminal GST

Insect (sf21)

BTN

BTN-FGFR4

08-436-20N

Cytoplasmic domain

460-802

NP_002002.3

N-terminal DYKDDDDK

Insect (sf21)

FGFR4 [N535K]

GST

FGFR4[N535K]

08-524

Cytoplasmic domain

460-802

NP_002002.3

N-terminal GST

Insect (sf21)

FGFR4 [V550E]

GST

FGFR4[V550E]

08-525

Cytoplasmic domain

460-802

NP_002002.3

N-terminal GST

Insect (sf21)

FGFR4 [V550L]

GST

FGFR4[V550L]

08-526

Cytoplasmic domain

460-802

NP_002002.3

N-terminal GST

Insect (sf21)

FGR

GST

FGR

08-166Full-length

1-529

NP_005239.1

N-terminal GST

Insect (sf21)

FLT1

GST

FLT1

08-189Cytoplasmic domain781-1338

NP_002010.1

N-terminal GST

Insect (sf21)

GST

FLT3

08-154

Cytoplasmic domain

564-993

NP_004110.2

N-terminal GST

Insect (sf21)

BTN

BTN-FLT308-454-21N

Cytoplasmic domain

564-993

NP_004110.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FLT3[non-activated]

08-454-23N

Cytoplasmic domain

564-993

NP_004110.2

N-terminal DYKDDDDK

Insect (sf21)

GST

FLT4

08-190

Cytoplasmic domain798-1298

NP_002011.1

N-terminal GST

Insect (sf21)

GST

FMS(CSF1R)

08-155

Cytoplasmic domain538-972

NP_005202.2

N-terminal GST

Insect (sf21)

BTN

BTN-FMS(CSF1R)

08-455-21N

Cytoplasmic domain538-972

NP_005202.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-FMS(CSF1R)[non-activated]

08-455-20N

Cytoplasmic domain538-972

NP_005202.2

N-terminal DYKDDDDK

Insect (sf21)

GST

FRK

08-167

Catalytic domain

223-505

NP_002022.1

N-terminal GST

Insect (sf21)

GST

FYN[isoforma]

08-168Full-length

1-537

NP_002028.1

N-terminal GST

Insect (sf21)

BTN

BTN-FYN[isoforma]

08-468-20N

Full-length

1-537

NP_002028.1

N-terminal DYKDDDDK

Insect (sf21)

FYN [isoform b]

GST

FYN[isoformb]

08-531

Full-length

1-534

NP_694592.1

N-terminal GST

Insect (sf21)

HCK

GST

HCK

08-169Truncated

25-526

NP_002101.2

N-terminal GST

Insect (sf21)

HER2(ERBB2)

HIS

HER2(ERBB2)

08-016

Cytoplasmic domain676-1255

NP_004439.1

N-terminal His

Insect (sf21)

HER4(ERBB4)

GST

HER4(ERBB4)

08-118

Cytoplasmic domain676-1308

NP_005226.1

N-terminal GST

Insect (sf21)

GST

IGF1R

08-141

Cytoplasmic domain959-1367

NP_000866.1

N-terminal GST

Insect (sf21)

BTN

BTN-IGF1R

08-441-20N

Cytoplasmic domain959-1367

NP_000866.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-IGF1R[non-activated]

08-441-23N

Cytoplasmic domain959-1367

NP_000866.1

N-terminal DYKDDDDK

Insect (sf21)

GST

INSR

08-142

Catalytic domain

1005-1310

NP_000199.2

N-terminal GST

Insect (sf21)

BTN

BTN-INSR

08-442-20N

Catalytic domain

1005-1310

NP_000199.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-INSR[non-activated]

08-442-23N

Catalytic domain

1005-1310

NP_000199.2

N-terminal DYKDDDDK

Insect (sf21)

GST

IRR(INSRR)

08-143

Cytoplasmic domain953-1297

NP_055030.1

N-terminal GST

Insect (sf21)

GST

ITK

08-181

Full-length

2-620

NP_005537.3

N-terminal GST

Insect (sf21)

BTN

BTN-ITK

08-481-20N

Full-length

2-620

NP_005537.3

N-terminal DYKDDDDK

Insect (sf21)

GST

JAK1

08-144

Catalytic domain

850-1154

NP_002218.2

N-terminal GST

Insect (sf21)

BTN

BTN-JAK1

08-444-20N

Catalytic domain

850-1154

NP_002218.2

N-terminal DYKDDDDK

Insect (sf21)

HIS

JAK2

08-045

Catalytic domain826-1132

NP_004963.1

N-terminal His

Insect (sf21)

BTN

BTN-JAK2

08-445-20N

Catalytic domain826-1132

NP_004963.1

N-terminal DYKDDDDK

Insect (sf21)

JAK2(JH1 JH2)

GST

JAK2(JH1JH2)

08-514

Catalytic/pseudo-kinase domain532-1132

NP_004963.1

N-terminal GST

Insect (sf21)

JAK2(JH1 JH2) [V617F]

GST

JAK2(JH1JH2)[V617F]

08-515

Catalytic/pseudo-kinase domain532-1132

NP_004963.1

N-terminal GST

Insect (sf21)

FGFR4

FLT3
FLT4
FMS(CSF1R)FRK
FYN [isoform a]

IGF1R

INSR
IRR(INSRR)
ITK
JAK1
JAK2

JAK3

HIS

JAK3

08-046

Catalytic domain795-1124

NP_000206.2

N-terminal His

Insect (sf21)

GST

KDR

08-191

Cytoplasmic domain790-1356

NP_002244.1

N-terminal GST

Insect (sf21)

BTN

BTN-KDR(VEGFR2)

08-491-20N

Cytoplasmic domain790-1356

NP_002244.1

N-terminal DYKDDDDK

Insect (sf21)

GST

KIT

08-156

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

BTN

BTN-KIT08-456-21N

Cytoplasmic domain544-976

NP_000213

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-KIT[non-activated]

08-456-23N

Cytoplasmic domain544-976

NP_000213

N-terminal DYKDDDDK

Insect (sf21)

KIT [D816E]

GST

KIT[D816E]

08-541

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [D816V]

GST

KIT[D816V]

08-505

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [D816Y]

GST

KIT[D816Y]

08-534

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [T670I]

GST

KIT[T670I]

08-195

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [T670I/D816V]

GST

KIT[T670I/D816V]

08-555

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [V560G]

GST

KIT[V560G]

08-504

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [V560G/D816V]

GST

KIT[V560G/D816V]

08-535

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

KIT [V654A/D816V]

GST

KIT[V654A/D816V]

08-554

Cytoplasmic domain544-976

NP_000213.1

N-terminal GST

Insect (sf21)

GST

LCK

08-170Full-length

1-509

NP_005347.2

N-terminal GST

Insect (sf21)

BTN

BTN-LCK

08-470-20N

Full-length

1-509

NP_005347.2

N-terminal DYKDDDDK

Insect (sf21)

LTK

GST

LTK

08-106

Catalytic domain498-796

NP_002335.2

N-terminal GST

Insect (sf21)

LTK [I565N]

GST

LTK[I565N]

08-593

Catalytic domain498-796

NP_002335.2

N-terminal GST

Insect (sf21)

LTK [L590M]

GST

LTK[L590M]

08-594

Catalytic domain498-796

NP_002335.2

N-terminal GST

Insect (sf21)

LTK [L592F]

GST

LTK[L592F]

08-595

Catalytic domain498-796

NP_002335.2

N-terminal GST

Insect (sf21)

LTK [L650F]

GST

LTK[L650F]

08-597

Catalytic domain498-796

NP_002335.2

N-terminal GST

Insect (sf21)

GST

LYNa

08-171

Full-length

1-512

NP_002341.1

N-terminal GST

Insect (sf21)

BTN

BTN-LYNa

08-471-20N

Full-length

1-512

NP_002341.1

N-terminal DYKDDDDK

Insect (sf21)

GST

LYNb

08-172Full-length

1-491

NP_001104567.1

N-terminal GST

Insect (sf21)

GST

MER(MERTK)

08-108

Cytoplasmic domain

528-999

NP_006334.2

N-terminal GST

Insect (sf21)

BTN

BTN-MER(MERTK)

08-408-20N

Cytoplasmic domain

528-999

NP_006334.2

N-terminal DYKDDDDK

Insect (sf21)

KDR(VEGFR2)

KIT

LCK

LYNa
LYNb
MER(MERTK)Page 3

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Tyrosine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
System

GST

MET

08-151

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET

08-451-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MET[D1228H]

08-540

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET[D1228H]

08-440-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MET[D1228N]

08-120

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET[D1228N]

08-760-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MET[M1250T]

08-545

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET[M1250T]

08-745-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-MET[Y1230C]

08-709-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MET[Y1230H]

08-178

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET[Y1230H]

08-478-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MET[Y1235D]

08-198

Cytoplasmic domain956-1390

NP_000236.2

N-terminal GST

Insect (sf21)

BTN

BTN-MET[Y1235D]

08-498-20N

Cytoplasmic domain956-1390

NP_000236.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MUSK

08-153

Catalytic domain

527-869

NP_005583.1

N-terminal GST

Insect (sf21)

BTN

BTN-MUSK

08-453-20N

Catalytic domain

527-869

NP_005583.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-MUSK[non-activated]

08-453-23N

Catalytic domain

527-869

NP_005583.1

N-terminal DYKDDDDK

Insect (sf21)

GST

NPM1-ALK

08-517

Fused

1-680

BAA08343.1

N-terminal GST

Insect (sf21)

GST

PDGFRα(PDGFRA)

08-157

Cytoplasmic domain

550-1089

NP_006197.1

N-terminal GST

Insect (sf21)

BTN

BTN-PDGFRα(PDGFRA)[non-activated]

08-457-23N

Cytoplasmic domain

550-1089

NP_006197.1

N-terminal DYKDDDDK

Insect (sf21)

PDGFRα(PDGFRA) [D842V]

GST

PDGFRα(PDGFRA)[D842V]

08-506

Cytoplasmic domain

550-1089

NP_006197.1

N-terminal GST

Insect (sf21)

PDGFRα(PDGFRA) [T674I]GSTPDGFRα(PDGFRA)[T674I]

08-503

Cytoplasmic domain

550-1089

NP_006197.1

N-terminal GST

Insect (sf21)

PDGFRα(PDGFRA) [V561D]GST

PDGFRα(PDGFRA)[V561D]

08-507

Cytoplasmic domain

550-1089

NP_006197.1

N-terminal GST

Insect (sf21)

GST

PDGFRβ(PDGFRB)

08-158

Cytoplasmic domain557-1106

NP_002600.1

N-terminal GST

Insect (sf21)

BTN

BTN-PDGFRβ(PDGFRB)

08-458-20N

Cytoplasmic domain557-1106

NP_002600.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-PDGFRβ(PDGFRB)[non-activated]

08-458-23N

Cytoplasmic domain557-1106

NP_002600.1

N-terminal DYKDDDDK

Insect (sf21)

GST

PYK2(PTK2B)

08-138Full-length

1-967

NP_775267.1

N-terminal GST

Insect (sf21)

BTN

BTN-PYK2(PTK2B)

08-438-20N

Full-length

1-967

NP_775267.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RET

08-159Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET

08-459-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RET[G691S]

08-522

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET[G691S]

08-722-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-RET[G691S][non-activated]

08-722-23N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

RET [G810C]

GST

RET[G810C]

08-572

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

RET [G810C/M918T]

GST

RET[G810C/M918T]

08-580

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

RET [G810R]

GST

RET[G810R]

08-573

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

RET [G810S]

GST

RET[G810S]

08-574

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

GST

RET[M918T]

08-508

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET[M918T]

08-708-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-RET[M918T][non-activated]

08-708-23N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RET[S891A]

08-523

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET[S891A]

08-723-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-RET[S891A][non-activated]

08-723-23N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RET[V804M]

08-560

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET[V804M]

08-460-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-RET[V804M][non-activated]

08-460-23N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RET[Y791F]

08-521

Cytoplasmic domain658-1114

NP_066124.1

N-terminal GST

Insect (sf21)

BTN

BTN-RET[Y791F]

08-721-20N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-RET[Y791F][non-activated]

08-721-23N

Cytoplasmic domain658-1114

NP_066124.1

N-terminal DYKDDDDK

Insect (sf21)

RON(MST1R)

GST

RON(MST1R)

08-152

Cytoplasmic domain979-1400

NP_002438.1

N-terminal GST

Insect (sf21)

ROS(ROS1)GSTROS(ROS1)

08-163

Cytoplasmic domain

1883-2347

NP_002935.2

N-terminal GST

Insect (sf21)

ROS(ROS1) [G2032R]

GST

ROS(ROS1)[G2032R]

08-585

Cytoplasmic domain

1883-2347

NP_002935.2

N-terminal GST

Insect (sf21)

ROS(ROS1) [G2032R/L2086F]

GST

ROS(ROS1)[G2032R/L2086F]

08-587

Cytoplasmic domain

1883-2347

NP_002935.2

N-terminal GST

Insect (sf21)

ROS(ROS1) [L2086F]

GST

ROS(ROS1)[L2086F]

08-586

Cytoplasmic domain

1883-2347

NP_002935.2

N-terminal GST

Insect (sf21)

GST

SRC

08-173Full-length

1-536

NP_005408.1

N-terminal GST

Insect (sf21)

BTN

BTN-SRC

08-473-20N

Full-length

1-536

NP_005408.1

N-terminal DYKDDDDK

Insect (sf21)

GST

SRM(SRMS)

08-174

Catalytic domain215-488

NP_543013.1

N-terminal GST

Insect (sf21)

GST

SYK

08-176Full-length

1-635

NP_003168.2

N-terminal GST

Insect (sf21)

BTN

BTN-SYK

08-476-20N

Full-length

1-635

NP_003168.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-SYK[non-activated]

08-476-23N

Full-length

1-635

NP_003168.2

N-terminal DYKDDDDK

Insect (sf21)

GST

TEC

08-182

Catalytic domain359-631

NP_003206.2

N-terminal GST

Insect (sf21)

BTN

BTN-TEC

08-482-20N

Catalytic domain359-631

NP_003206.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-TEC[non-activated]

08-482-23N

Catalytic domain359-631

NP_003206.2

N-terminal DYKDDDDK

Insect (sf21)

GST

TIE2(TEK)

08-185

Cytoplasmic domain

771-1124

NP_000450.1

N-terminal GST

Insect (sf21)

BTN

BTN-TIE2

08-485-20N

Cytoplasmic domain

771-1124

NP_000450.1

N-terminal DYKDDDDK

Insect (sf21)

GST

TNK1

08-104

Catalytic domain

106-390

Q13470-2

N-terminal GST

Insect (sf21)

GST

TRKA(NTRK1)

08-186

Cytoplasmic domain436-790

NP_001012331.1

N-terminal GST

Insect (sf21)

BTN

BTN-TRKA(NTRK1)

08-486-20N

Cytoplasmic domain436-790

NP_001012331.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-TRKA(NTRK1)[non-activated]

08-486-23N

Cytoplasmic domain436-790

NP_001012331.1

N-terminal DYKDDDDK

Insect (sf21)

GST

TRKB(NTRK2)

08-187

Cytoplasmic domain

456-822NP_001018074.1

N-terminal GST

Insect (sf21)

BTN

BTN-TRKB(NTRK2)

08-487-20N

Cytoplasmic domain

456-822NP_001018074.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-TRKB(NTRK2)[non-activated]

08-487-23N

Cytoplasmic domain

456-822NP_001018074.1

N-terminal DYKDDDDK

Insect (sf21)

GST

TRKC(NTRK3)

08-197

Cytoplasmic domain

456-825

NP_002521.2

N-terminal GST

Insect (sf21)

BTN

BTN-TRKC(NTRK3)

08-497-20N

Cytoplasmic domain

456-825

NP_002521.2

N-terminal DYKDDDDK

Insect (sf21)

GST

TXK

08-183

Catalytic domain

260-527

NP_003319.2

N-terminal GST

Insect (sf21)

BTN

BTN-TXK

08-483-20N

Catalytic domain

260-527

NP_003319.2

N-terminal DYKDDDDK

Insect (sf21)

GST

TYK2

08-147

Catalytic domain871-1187

NP_003322.3

N-terminal GST

Insect (sf21)

BTN

BTN-TYK2

08-447-20N

Catalytic domain871-1187

NP_003322.3

N-terminal DYKDDDDK

Insect (sf21)

GST

TYK2(JH1 JH2)

08-148

Catalytic/pseudo-kinase domain556-1187

NP_003322.3

N-terminal GST

Insect (sf21)

BTN

BTN-TYK2(JH1 JH2)

08-448-20N

Catalytic/pseudo-kinase domain556-1187

NP_003322.3

N-terminal DYKDDDDK

Insect (sf21)

MET
MET [D1228H]
MET [D1228N]
MET [M1250T]
MET [Y1230C]
MET [Y1230H]
MET [Y1235D]

MUSK
NPM1-ALKPDGFRα(PDGFRA)PDGFRβ(PDGFRB)

PYK2(PTK2B)
RET

RET [G691S]

RET [M918T]

RET [S891A]

RET [V804M]

RET [Y791F]

SRC
SRM(SRMS)
SYK

TEC

TIE2(TEK)TNK1
TRKA(NTRK1)

TRKB(NTRK2)

TRKC(NTRK3)
TXK
TYK2
TYK2(JH1 JH2)

Page 4

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Tyrosine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

TYRO3

08-109Cytoplasmic domain453-890

NP_006284.2

N-terminal GST

Insect (sf21)

BTN

BTN-TYRO3

08-409-20N

Cytoplasmic domain453-890

NP_006284.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-TYRO3[non-activated]

08-409-23N

Cytoplasmic domain453-890

NP_006284.2

N-terminal DYKDDDDK

Insect (sf21)

GST

YES(YES1)

08-175Full-length

1-543

NP_005424.1

N-terminal GST

Insect (sf21)

BTN

BTN-YES(YES1)

08-475-20N

Full-length

1-543

NP_005424.1

N-terminal DYKDDDDK

Insect (sf21)

YES(YES1) [T348I]GST

YES(YES1)[T348I]

08-533Full-length

1-543

NP_005424.1

N-terminal GST

Insect (sf21)

ZAP70

GST

ZAP70

08-177Full-length

1-619

NP_001070

N-terminal GST

Insect (sf21)

TYRO3

YES(YES1)

Serine / Threonine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

ACTR2B(ACVR2B)

09-132

Cytoplasmic domain161-512

NP_001097.2

N-terminal GST

BTN

BTN-ACTR2B(ACVR2B)

09-432-20N

Cytoplasmic domain161-512

NP_001097.2

N-terminal DYKDDDDK

Insect (sf21)

GST

ACVR1C(ALK7)

09-150

Cytoplasmic domain139-493

NP_660302.2

N-terminal GST

Insect (sf21)

GST

ACVR2A

09-131

Cytoplasmic domain

162-513

NP_001607.1

N-terminal GST

Insect (sf21)

BTN

BTN-ACVR2A

09-431-20N

Cytoplasmic domain

162-513

NP_001607.1

N-terminal DYKDDDDK

Insect (sf21)

GST

ACVRL1(ALK1)

09-133

Truncated139-503

NP_000011.2

N-terminal GST

Insect (sf21)

GST

AKT1

01-101

Catalytic domain

104-480

NP_005154.2

N-terminal GST

Insect (sf21)

BTN

BTN-AKT1

01-401-20N

Catalytic domain

104-480

NP_005154.2

N-terminal DYKDDDDK

Insect (sf21)

GST

AKT2

01-102

Catalytic domain

120-481

NP_001617.1

N-terminal GST

Insect (sf21)

BTN

BTN-AKT2

01-402-20N

Catalytic domain

120-481

NP_001617.1

N-terminal DYKDDDDK

Insect (sf21)

AKT3

GST

AKT3

01-103

Catalytic domain

108-479

NP_005456.1

N-terminal GST

Insect (sf21)

ALK2(ACVR1)

GST

ALK2(ACVR1)

09-134

Truncated145-509

NP_001096.1

N-terminal GST

Insect (sf21)

ALK2(ACVR1) [Q207D]

GST

ALK2(ACVR1)[Q207D]

09-149Truncated145-509

NP_001096.1

N-terminal GST

Insect (sf21)

ALK2(ACVR1) [R206H]

GST

ALK2(ACVR1)[R206H]

09-148

Truncated145-509

NP_001096.1

N-terminal GST

Insect (sf21)

ALK4(ACVR1B)

GST

ALK4(ACVR1B)

09-135

Cytoplasmic domain

150-505

NP_004293.1

N-terminal GST

Insect (sf21)

GST

AMPKα1/β1/γ1(PRKAA1/B1/G1)

02-113Full-length

1-550

NP_006242.4

N-terminal GST

Insect (sf21)

ACTR2B(ACVR2B)
ACVR1C(ALK7)
ACVR2AACVRL1(ALK1)
AKT1
AKT2

AMPKα1/β1/γ1(PRKAA1/B1/G1)

Insect (sf21)

BTN

BTN-AMPKα1/β1/γ1(PRKAA1/B1/G1)

02-413-20N

Full-length

1-550

NP_006242.4

N-terminal DYKDDDDK

Insect (sf21)

GST

AMPKα1/β2/γ1(PRKAA1/B2/G1)

02-147Full-length

1-550

NP_006242.4

N-terminal GST

Insect (sf21)

BTN

BTN-AMPKα1/β2/γ1(PRKAA1/B2/G1)

02-447-20N

Full-length

1-550

NP_006242.4

N-terminal DYKDDDDK

Insect (sf21)

AMPKα2/β1/γ1(PRKAA2/B1/G1)

GST

AMPKα2/β1/γ1(PRKAA2/B1/G1)

02-114Full-length

1-552

NP_006243.2

N-terminal GST

Insect (sf21)

AMPKα2/β2/γ1(PRKAA2/B2/G1)

GST

AMPKα2/β2/γ1(PRKAA2/B2/G1)

02-148Full-length

1-552

NP_006243.2

N-terminal GST

Insect (sf21)

GST

AurA(AURKA)

05-101

Full-length

1-403

NP_940835.1

N-terminal GST

Insect (sf21)

BTN

BTN-AurA(AURKA)

05-401-20N

Full-length

1-403

NP_940835.1

N-terminal DYKDDDDK

Insect (sf21)

GST

AurB(AURKB)/INCENP

05-102Full-length

1-344

NP_004208.2

N-terminal GST

Insect (sf21)

BTN

BTN-AurB(AURKB)/INCENP

05-402-21N

Full-length

1-344

NP_004208.2

N-terminal DYKDDDDK

Insect (sf21)

GST

AurC(AURKC)

05-103Full-length

1-275

NP_003151.2

N-terminal GST

Insect (sf21)

GST

BARK1(ADRBK1)

01-111

Full-length

1-689

NP_001610.2

N-terminal GST

Insect (sf21)

BTN

BTN-BARK1(ADRBK1)

01-411-20N

Full-length

1-689

NP_001610.2

N-terminal DYKDDDDK

Insect (sf21)

BARK2(ADRBK2)

GST

BARK2(ADRBK2)

01-112Full-length

1-688

NP_005151.2

N-terminal GST

Insect (sf21)

BMPR1AGST

BMPR1A

09-137

Catalytic domain

187-532

NP_004320.2

N-terminal GST

Insect (sf21)

BMPR1BGST

BMPR1B

09-138

Cytoplasmic domain

149-502

NP_001194.1

N-terminal GST

Insect (sf21)

BMPR2

GST

BMPR2

09-139Cytoplasmic domain

174-1038

NP_001195.2

N-terminal GST

Insect (sf21)

GST

BRAF

09-122

Catalytic domain433-726

NP_004324.2

N-terminal GST

Insect (sf21)

BTN

BTN-BRAF

09-422-20N

Catalytic domain433-726

NP_004324.2

N-terminal DYKDDDDK

Insect (sf21)

BRAF [T599_V600insT]

GST

BRAF[T599_V600insT]

09-147

Catalytic domain433-726

NP_004324.2

N-terminal GST

Insect (sf21)

BRAF [V600E]

GST

BRAF[V600E]

09-144

Catalytic domain433-726

NP_004324.2

N-terminal GST

Insect (sf21)

BRSK1

GST

BRSK1

02-115Full-length

1-778

NP_115806.1

N-terminal GST

Insect (sf21)

BRSK2

GST

BRSK2

02-116Full-length

1-674

ABA17261.1

N-terminal GST

Insect (sf21)

GST

BUB1/BUB3

05-187Full-length

1-1085

NP_004327

N-terminal GST

Insect (sf21)

BTN

BTN-BUB1/BUB3

05-487-20N

Full-length

1-1085

NP_004327

N-terminal DYKDDDDK

Insect (sf21)

BUBR1(BUB1B)

GST

BUBR1(BUB1B)

05-105Full-length

1-1050

NP_001202.4

N-terminal GST

Insect (sf21)

CaMK1α(CAMK1)

GST

CaMK1α(CAMK1)

02-104Full-length

1-370

NP_003647.1

N-terminal GST

Insect (sf21)

CaMK1β(PNCK)GSTCaMK1β(PNCK)

02-105Full-length

1-343

Q6P2M8N-terminal GST

Insect (sf21)

CaMK1δ(CAMK1D)GST

CaMK1δ(CAMK1D)

02-106Full-length

1-357

NP_065130.1

N-terminal GST

Insect (sf21)

CaMK2α(CAMK2A)

GST

CaMK2α(CAMK2A)

02-109Full-length

1-478

NP_741960.1

N-terminal GST

Insect (sf21)

GST

CaMK2β(CAMK2B)

02-110Full-length

1-503

NP_742078.1(iso5)

N-terminal GST

Insect (sf21)

BTN

BTN-CaMK2β(CAMK2B)

02-410-20N

Full-length

1-503

NP_742078.1(iso5)

N-terminal DYKDDDDK

Insect (sf21)

GST

CaMK2γ(CAMK2G)

02-112Full-length

1-518

NP_751910.1

N-terminal GST

Insect (sf21)

GST

CaMK2δ(CAMK2D)

02-111

Full-length

1-478

NP_742113.1

N-terminal GST

Insect (sf21)

BTN

BTN-CaMK2δ(CAMK2D)

02-411-20N

Full-length

1-478

NP_742113.1

N-terminal DYKDDDDK

Insect (sf21)

CaMK4

GST

CaMK4

02-108Full-length

1-473

NP_001735.1

N-terminal GST

Insect (sf21)

CAMKK1GST

CAMKK105-107Full-length

1-505

NP_115670.1

N-terminal GST

Insect (sf21)

CAMKK2GST

CAMKK205-108Full-length

1-588

NP_006540.3(isoform-1)

N-terminal GST

Insect (sf21)

CDC7/ASK

GST

CDC7/ASK

05-109Full-length

1-574

NP_003494.1

N-terminal GST

Insect (sf21)

CDK1(CDC2)BTN

BTN-CDK1(CDC2)

04-480-20N

Full-length

1-297

NP_001777.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK1(CDC2)/CycA2

04-119Full-length

1-297

NP_001777.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK1(CDC2)/CycA2

04-419-20N

Full-length

1-297

NP_001777.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK1(CDC2)/CycB1

04-102Full-length

1-297

NP_001777.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK1(CDC2)/CycB1

04-402-20N

Full-length

1-297

NP_001777.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK1(CDC2)/CycE1

04-176Full-length

1-297

NP_001777.1

N-terminal GST

Insect (sf21)

GST

CDK2/CycA2

04-103Full-length

1-298

NP_001789.2

N-terminal GST

Insect (sf21)

BTN

BTN-CDK2/CycA2

04-403-20N

Full-length

1-298

NP_001789.2

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK2/CycE1

04-165Full-length

1-298

NP_001789.2

N-terminal GST

Insect (sf21)

BTN

BTN-CDK2/CycE1

04-465-20N

Full-length

1-298

NP_001789.2

N-terminal DYKDDDDK

Insect (sf21)

CDK3

BTN

BTN-CDK3

04-481-20N

Full-length

1-305

NP_001249.1

N-terminal DYKDDDDK

Insect (sf21)

CDK3/CycC

GST

CDK3/CycC

04-174Full-length

1-305

NP_001249.1

N-terminal GST

Insect (sf21)

GST

CDK3/CycE1

04-104Full-length

1-305

NP_001249.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK3/CycE1

04-404-20N

Full-length

1-305

NP_001249.1

N-terminal DYKDDDDK

Insect (sf21)

AMPKα1/β2/γ1(PRKAA1/B2/G1)

AurA(AURKA)
AurB(AURKB)/INCENP
AurC(AURKC)
BARK1(ADRBK1)

BRAF

BUB1/BUB3

CaMK2β(CAMK2B)
CaMK2γ(CAMK2G)
CaMK2δ(CAMK2D)

CDK1(CDC2)/CycA2
CDK1(CDC2)/CycB1
CDK1(CDC2)/CycE1
CDK2/CycA2
CDK2/CycE1

CDK3/CycE1

Page 5

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Serine / Threonine Kinases
Protein Kinase
CDK4/CycD1

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

CDK4/CycD1

04-120Full-length

1-303

NP_000066.1

N-terminal GST

Insect (sf21)

GST

CDK4/CycD3

04-105Full-length

1-303

NP_000066.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK4/CycD3

04-405-20N

Full-length

1-303

NP_000066.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-CDK5

04-493-20N

Full-length

1-292

NP_004926.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK5/p25

04-106Full-length

1-292

NP_004926.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK5/p25

04-406-20N

Full-length

1-292

NP_004926.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK5/p35

04-192Full-length

1-292

NP_004926.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK5/p35

04-492-20N

Full-length

1-292

NP_004926.1

N-terminal DYKDDDDK

Insect (sf21)

CDK6

BTN

BTN-CDK6

04-494-20N

Full-length

1-326

NP_001250.1

N-terminal DYKDDDDK

Insect (sf21)

CDK6/CycD1

GST

CDK6/CycD1

04-114Full-length

1-326

NP_001250.1

N-terminal GST

Insect (sf21)

GST

CDK6/CycD3

04-107Full-length

1-326

NP_001250.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK6/CycD3

04-407-20N

Full-length

1-326

NP_001250.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-CDK6/CycD3[non-activated]

04-407-23N

Full-length

1-326

NP_001250.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK7/CycH/MAT1

04-108Full-length

1-346

NP_001790.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK7/CycH/MAT1

04-408-20N

Full-length

1-346

NP_001790.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK8/CycC

04-109Full-length

1-464

NP_001251.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK8/CycC

04-409-20N

Full-length

1-464

NP_001251.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK9/CycK

04-111

Full-length

1-372

NP_001252.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK9/CycK

04-411-20N

Full-length

1-372

NP_001252.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK9/CycT1

04-110Full-length

1-372

NP_001252.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK9/CycT1

04-410-20N

Full-length

1-372

NP_001252.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CDK9/CycT2

04-121

Full-length

1-372

NP_001252.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK9/CycT2

04-421-20N

Full-length

1-372

NP_001252.1

N-terminal DYKDDDDK

Insect (sf21)

CDK10(PISSLRE)/CycQ

GST

CDK10(PISSLRE)/CycQ

04-171

Full-length

1-360

NP_443714.3

N-terminal GST

Insect (sf21)

CDK12(CRKRS)(720-1490aa)/CycKBTN

BTN-CDK12(CRKRS)(720-1490aa)/CycK

04-413-20N

Truncated

720-1490

NP_057591.2

N-terminal DYKDDDDK

Insect (sf21)

CDK4/CycD3
CDK5
CDK5/p25
CDK5/p35

CDK6/CycD3

CDK7/CycH/MAT1
CDK8/CycC
CDK9/CycKCDK9/CycT1
CDK9/CycT2

CDK13(CHED)(694-1512aa)/CycKBTN

BTN-CDK13(CHED)(694-1512aa)/CycK

04-482-20N

Truncated694-1512

NP_003709.3

GST

CDK13(CHED)/CycK

04-123

Catalytic domain694-1039

NP_003709.3

BTN

BTN-CDK13(CHED)/CycK

04-483-20N

Catalytic domain694-1039

NP_003709.3

N-terminal GST,
N-terminal His
N-terminal DYKDDDDKGSTCDK19(CDC2L6)/CycC

04-112Full-length

1-502

NP_055891.1

N-terminal GST

Insect (sf21)

BTN

BTN-CDK19(CDC2L6)/CycC

04-412-20N

Full-length

1-502

NP_055891.1

N-terminal DYKDDDDK

Insect (sf21)

CGK2(PRKG2)GST

CGK2(PRKG2)

01-143Full-length

1-762

NP_006250.1

N-terminal GST

Insect (sf21)

CHAK1(TRPM7)

GST

CHAK1(TRPM7)

10-111

Catalytic domain

1158-1865

NP_060142.3

N-terminal GST

Insect (sf21)

GST

CHK1(CHEK1)

02-117Full-length

1-476

NP_001265.2

N-terminal GST

Insect (sf21)

BTN

BTN-CHK1(CHEK1)

02-417-20N

Full-length

1-476

NP_001265.2

N-terminal DYKDDDDK

Insect (sf21)

CHK2(CHEK2)

GST

CHK2(CHEK2)

02-162Full-length

1-543

NP_009125.1

N-terminal GST

Insect (sf21)

CK1α(CSNK1A1)

GST

CK1α(CSNK1A1)

03-101

Full-length

1-337

NP_001883.4

N-terminal GST

Insect (sf21)

CK1γ1(CSNK1G1)

GST

CK1γ1(CSNK1G1)

03-105Full-length

1-422

NP_071331.2

N-terminal GST

Insect (sf21)

CK1γ2(CSNK1G2)

GST

CK1γ2(CSNK1G2)

03-106Full-length

1-415

NP_001310.3

N-terminal GST

Insect (sf21)

CK1γ3(CSNK1G3)

GST

CK1γ3(CSNK1G3)

03-107Full-length

1-447

NP_004375.2

N-terminal GST

Insect (sf21)

CK1δ(CSNK1D)GST

CK1δ(CSNK1D)

03-103

Catalytic domain

1-294

NP_001884.2

N-terminal GST

E. coliCK1ε(CSNK1E)

GST

CK1ε(CSNK1E)

03-104

Catalytic domain

1-348

NP_001885.1

N-terminal GST

05-184Full-length(CK2α1)

NP_001886.1(CK2α1),
NP 001311 3(CK2β)
NP_0011887.1(CK2α2),
NP 001311 3(CK2β)
NP_004062.2

N-terminal GST(CK2α1),N-terminal His(CK2β)
N-terminal GST(CK2α2),N-terminal His(CK2β)
N-terminal GST

CDK13(CHED)/CycK
CDK19(CDC2L6)/CycC

CHK1(CHEK1)

05-185Full-length(CK2α2)

CLK104-126

Catalytic domain

GST

CLK2

04-127Full-length

1-499

NP_001281267.1

N-terminal GST

Insect (sf21)

BTN

BTN-CLK2

04-427-20N

Full-length

1-499

NP_001281267.1

N-terminal DYKDDDDK

Insect (sf21)

GST

CLK3

04-128Full-length

1-490

NP_003983.2

N-terminal GST

Insect (sf21)

GST

CLK4

04-129Full-length

1-481

NP_065717.1

N-terminal GST

Insect (sf21)

BTN

BTN-CLK4

04-429-20N

Full-length

1-481

NP_065717.1

N-terminal DYKDDDDK

Insect (sf21)

COT(MAP3K8)07-301 (Tag-free)

Catalytic domain

30-397

NP_005195.2

Tag-freeInsect (sf21)

CK2α2/β(CSNK2A2/B)

GST/HIS

CLK4
COT(MAP3K8)

Insect (sf21)

CK2α2/β(CSNK2A2/B)

CK2α1/β(CSNK2A1/B)

CLK3

Insect (sf21)

GST

GST/HIS

CLK2

Insect (sf21)
Insect (sf21)

1-391(CK2α1),1-215(CK2β)
1-350(CK2α2),1-215(CK2β)
129-484

CK2α1/β(CSNK2A1/B)
CLK1

N-terminal DYKDDDDK

Tag-freeInsect (sf21)
Insect (sf21)
Insect (sf21)

CRIK(CIT)

GST

CRIK(CIT)

01-104

Catalytic domain

1-449

NP_009105.1

N-terminal GST

Insect (sf21)

DAPK1

GST

DAPK1

02-134

Catalytic domain

1-289

NP_004929.1

N-terminal GST

Insect (sf21)

GST

DAPK3

02-136Full-length

1-454

NP_001339.1

N-terminal GST

Insect (sf21)

BTN

BTN-DAPK3

02-436-20N

Full-length

1-454

NP_001339.1

N-terminal DYKDDDDK

Insect (sf21)

DCAMKL1GST

DCAMKL1

02-139Full-length

1-729

NP_004725.1

N-terminal GST

Insect (sf21)

DCAMKL2GST

DCAMKL2

02-140

Truncated

1-691

NP_001035350.2

N-terminal GST

Insect (sf21)

GST

DLK(MAP3K12)

09-111

Catalytic domain

1-520

NP_006292.3

N-terminal GST

Insect (sf21)

BTN

BTN-DLK(MAP3K12)

09-411-20N

Catalytic domain

1-520

NP_006292.3

N-terminal DYKDDDDK

Insect (sf21)

DMPK1(DMPK)GSTDMPK1(DMPK)

01-105

Catalytic domain

1-544

NP_001075032.1

N-terminal GST

Insect (sf21)

DMPK2(CDC42BPG)

GST

DMPK2(CDC42BPG)

01-106

Catalytic domain

1-473

NP_059995.2

N-terminal GST

Insect (sf21)

DRAK1(STK17A)

GST

DRAK1(STK17A)

02-137Full-length

1-414

NP_004751.2

N-terminal GST

Insect (sf21)

GST

DYRK1A

04-130Full-length

1-763

NP_001387.2

N-terminal GST

Insect (sf21)

BTN

BTN-DYRK1A

04-430-20N

Full-length

1-763

NP_001387.2

N-terminal DYKDDDDK

Insect (sf21)

DYRK1BGSTDYRK1B

04-131

Full-length

1-629

NP_004705.1

N-terminal GST

Insect (sf21)

DYRK2

GST

DYRK2

04-132Full-length

1-528

NP_003574.1

N-terminal GST

Insect (sf21)

DYRK3

GST

DYRK3

04-133Full-length

1-588

NP_003573.2

N-terminal GST

Insect (sf21)

DYRK4

DYKDDDDK

DYRK404-434Full-length

1-520

NP_003836.1

N-terminal DYKDDDDK

Insect (sf21)

EEF2K

GST

EEF2K

10-113Full-length

1-725

NP_037434.1

N-terminal GST

E. coliErk1(MAPK3)

GST

Erk1(MAPK3)

04-142Full-length

1-379

NP_002737.1

N-terminal GST

E. coliErk2(MAPK1)

GST

Erk2(MAPK1)

04-143Full-length

1-360

NP_002736.3

N-terminal GST

E. coliErk5(MAPK7)

GST

Erk5(MAPK7)

04-146

Catalytic domain

1-398

NP_002740.2

N-terminal GST

E. coliErk7(MAPK15)

GST

Erk7(MAPK15)

04-147Full-length

1-544

NP_620590.2

N-terminal GST

Insect (sf21)

GST

GCN2(EIF2AK4)

05-153Full-length

1-1649NP_001013725

N-terminal GST

Insect (sf21)

BTN

BTN-GCN2(EIF2AK4)

05-453-20N

Full-length

1-1649NP_001013725

N-terminal DYKDDDDK

Insect (sf21)
Insect (sf21)

DAPK3

DLK(MAP3K12)DYRK1A

GCN2(EIF2AK4)
GPRK4(GRK4)

Tag-free

GPRK4(GRK4)

01-313 (Tag-free)

Full-length

1-578

NP_892027.2

Tag-freeGPRK6(GRK6)

Tag-freeGPRK6(GRK6)

01-315 (Tag-free)

Full-length

1-560

NP_001004105.2

Tag-freeInsect (sf21)

GPRK7(GRK7)

GSTGPRK7(GRK7)

01-116Full-length

1-553

NP_631948.1

N-terminal GST

Insect (sf21)

GSK3α(GSK3A)

GST

GSK3α(GSK3A)

04-140Full-length

1-483

NP_063937.2

N-terminal GST

Insect (sf21)

GST

GSK3β(GSK3B)

04-141

Full-length

1-420

NP_001139628.1

N-terminal GST

Insect (sf21)

BTN

BTN-GSK3β(GSK3B)

04-441-20N

Full-length

1-420

NP_001139628.1

N-terminal DYKDDDDK

Insect (sf21)

GSK3β(GSK3B)

Page 6

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Serine / Threonine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
System

Haspin(GSG2)

GST

Haspin(GSG2)

05-111

Full-length

1-798

NP_114171.2

N-terminal GST

Insect (sf21)

HGK(MAP4K4)GST

HGK(MAP4K4)

07-137

Catalytic domain

1-328

NP_004825.2

N-terminal GST

Insect (sf21)

HH498 (TNNI3K)

GST

HH498(TNNI3K)

09-112

Catalytic domain

1-727

NP_057062.1

N-terminal GST

Insect (sf21)

HIPK1

GST

HIPK1

04-135

Catalytic domain

158-555

NP_689909.2

N-terminal GST

Insect (sf21)

HIPK2

GST

HIPK2

04-136Full-length

1-1198NP_073577.3

N-terminal GST

Insect (sf21)

HIPK3

GST

HIPK3

04-137

Catalytic domain161-562

NP_005725.3

N-terminal GST

Insect (sf21)

HIPK4

GST

HIPK4

04-138Full-length

1-616

NP_653286.2

N-terminal GST

Insect (sf21)

HPK1(MAP4K1)

DYKDDDDK

HPK1(MAP4K1)

07-410Catalytic domain

1-346

NP_009112.1

N-terminal DYKDDDDK

Insect (sf21)

HRI(EIF2AK1)

GST

HRI(EIF2AK1)

05-154Full-length

1-630

BAC11461.1

N-terminal GST

E. coli

ICK

GST

ICK

04-156Full-length

1-632

NP_057597.2

N-terminal GST

Insect (sf21)

GST

IKKα(CHUK)

05-112Full-length

1-745

NP_001269.3

N-terminal GST

Insect (sf21)

BTN

BTN-IKKα(CHUK)

05-412-20N

Full-length

1-745

NP_001269.3

N-terminal DYKDDDDK

Insect (sf21)

HIS

IKKβ(IKBKB)

05-084

Truncated

1-662

NP_001547.1

N-terminal His

Insect (sf21)

BTN

BTN-IKKb(IKBKB)

05-484-20N

Truncated

1-662

NP_001547.1

N-terminal DYKDDDDK

Insect (sf21)

GST

IKKε(IKBKE)

05-114Full-length

1-716

NP_054721.1

N-terminal GST

Insect (sf21)

IKKα(CHUK)IKKβ(IKBKB)IKKε(IKBKE)
IRAK1

GST

IRAK1

09-101

Truncated

194-712

NP_001560.2

N-terminal GST

Insect (sf21)

GST

IRAK4

09-145Full-length

1-460

NP_057207.2

N-terminal GST

Insect (sf21)

BTN

BTN-IRAK4

09-445-20N

Full-length

1-460

NP_057207.2

N-terminal DYKDDDDK

Insect (sf21)

JNK1(MAPK8)GSTJNK1(MAPK8)

04-163

Catalytic domain

2-364

NP_620634.1

N-terminal GST

E. coli

JNK2(MAPK9)GSTJNK2(MAPK9)04-164

Catalytic domain

1-364

NP_002743.3

N-terminal GST

E. coli

JNK3(MAPK10)GST

JNK3(MAPK10)04-150Full-length

1-426

NP_620446.1

N-terminal GST

E. coli

LATS1/MOBKL1A

GST

LATS1/MOBKL1A

01-523

Catalytic domain589-1130

NP_004681.1

N-terminal GST

Insect (sf21)

GST

LATS2/MOBKL1A

01-524

Catalytic domain553-1088

NP_055387.2

N-terminal GST

Insect (sf21)

BTN

BTN-LATS2/MOBKL1A

01-424-20N

Catalytic domain553-1088

NP_055387.2

N-terminal DYKDDDDK

Insect (sf21)

GST

LIMK1

09-105

Truncated

285-638

NP_002305.1

N-terminal GST

Insect (sf21)

GST

LIMK2

09-106Full-length

1-638

NP_005560.1

N-terminal GST

Insect (sf21)

BTN

BTN-LIMK2

09-406-20N

Full-length

1-638

NP_005560.1

N-terminal DYKDDDDK

Insect (sf21)

LKB1(STK11)/MO25α/STRADαGST

LKB1(STK11)/MO25α/STRADα

02-119Full-length

1-433

NP_000446.1

N-terminal GST

Insect (sf21)

LOK(STK10)

GST

LOK(STK10)

07-115Full-length

1-968

NP_005981.3

N-terminal GST

Insect (sf21)

LRRK2

GST

LRRK2

09-110Catalytic domain

960-2527

NP_940980.4

N-terminal GST

Insect (sf21)

IRAK4

LATS2/MOBKL1A
LIMK1
LIMK2

LRRK2 [G2019S]GST

LRRK2[G2019S]

09-146

Catalytic domain

960-2527

NP_940980.4

N-terminal GST

Insect (sf21)

LZK(MAP3K13)

GST

LZK(MAP3K13)

09-114Full-length

1-966

NP_004712.1

N-terminal GST

Insect (sf21)

MAP2K1

GST

MAP2K107-141

Full-length

1-393

NP_002746.1

N-terminal GST

Insect (sf21)

MAP2K1 [F129L]

GST

MAP2K1[F129L]

07-151

Full-length

1-393

NP_002746.1

N-terminal GST

Insect (sf21)

MAP2K1 [P124L]

GST

MAP2K1[P124L]

07-150Full-length

1-393

NP_002746.1

N-terminal GST

Insect (sf21)

MAP2K2GST

MAP2K207-142Full-length

1-400

NP_109587.1

N-terminal GST

Insect (sf21)

MAP2K3

GST

MAP2K307-143Full-length

1-347

NP_659731.1

N-terminal GST

Insect (sf21)

MAP2K4GST

MAP2K407-144Full-length

1-399

NP_003001.1

N-terminal GST

Insect (sf21)

MAP2K5GST

MAP2K507-145Full-length

1-448

NP_660143.1

N-terminal GST

Insect (sf21)

MAP2K6GST

MAP2K607-146Full-length

1-334

NP_002749.2

N-terminal GST

Insect (sf21)

MAP2K7GST

MAP2K707-148Full-length

1-419

NP_660186.1

N-terminal GST

Insect (sf21)

MAP3K1

GST

MAP3K107-103

Catalytic domain1327-1646

XP_042066.8

N-terminal GST

Insect (sf21)

MAP3K2

GST

MAP3K207-104

Catalytic domain337-620

NP_006600.3

N-terminal GST

Insect (sf21)

MAP3K3

GST

MAP3K307-105Full-length

1-626

NP_002392.2

N-terminal GST

Insect (sf21)

MAP3K4GST

MAP3K407-106

Catalytic domain1312-1608

NP_005913.2

N-terminal GST

Insect (sf21)

GST

MAP3K507-107

Catalytic domain654-971

NP_005914.1

N-terminal GST

Insect (sf21)

BTN

BTN-MAP3K5

07-407-20N

Catalytic domain654-971

NP_005914.1

N-terminal DYKDDDDK

Insect (sf21)

MAP3K6GST

MAP3K607-108

Catalytic domain

622-950

NP_004663.3

N-terminal GST

Insect (sf21)

MAP3K14GST

MAP3K1407-102

Catalytic domain

319-947

NP_003945.2

N-terminal GST

Insect (sf21)

MAP4K2

GST

MAP4K207-111

Full-length

1-820

NP_004570.2

N-terminal GST

Insect (sf21)

MAP4K5(KHS1)

GST

MAP4K5(KHS1)

07-113Full-length

1-846

NP_006566.2

N-terminal GST

Insect (sf21)

MAPKAPK2

GST

MAPKAPK2

02-142Full-length

1-400

NP_116584.2

N-terminal GST

Insect (sf21)

MAPKAPK3

GST

MAPKAPK3

02-143Full-length

1-382

NP_004626.1

N-terminal GST

Insect (sf21)

MAPKAPK5

GST

MAPKAPK502-144Full-length

1-471

NP_003659.2

N-terminal GST

Insect (sf21)

MARK1

GST

MARK1

02-120Full-length

1-795

AAF72103.1

N-terminal GST

Insect (sf21)

MARK2

GST

MARK2

02-121

Full-length

1-745

NP_059672.2

N-terminal GST

Insect (sf21)

MARK3

GST

MARK3

02-122Full-length

1-729

NP_002367.4

N-terminal GST

Insect (sf21)

MARK4

GST

MARK4

02-123Full-length

1-688

NP_113605.2

N-terminal GST

Insect (sf21)

MELK

GST

MELK

02-124

Truncated

1-493

NP_055606.1

N-terminal GST

E. coliMINK(MINK1)GST

MINK(MINK1)

07-139Catalytic domain

1-314

NP_056531.1

N-terminal GST

Insect (sf21)

GST

MLK1(MAP3K9)

09-115

Catalytic domain

110-422

NP_149132.2

N-terminal GST

Insect (sf21)

BTN

BTN-MLK1(MAP3K9)

09-415-20N

Catalytic domain

110-422

NP_149132.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MLK2(MAP3K10)

09-116

Catalytic domain

75-462

NP_002437.2

N-terminal GST

Insect (sf21)

BTN

BTN-MLK2(MAP3K10)

09-416-20N

Catalytic domain

75-462

NP_002437.2

N-terminal DYKDDDDK

Insect (sf21)

GST

MLK3(MAP3K11)

09-117

Catalytic domain

99-398NP_002410.1

N-terminal GST

Insect (sf21)

BTN

BTN-MLK3(MAP3K11)

09-417-20N

Catalytic domain

99-398NP_002410.1

N-terminal DYKDDDDK

Insect (sf21)

GST

MLK4

09-118

Catalytic domain

114-420

NP_115811.2

N-terminal GST

Insect (sf21)

GST

MNK1(MKNK1)

02-145Full-length

1-424

NP_001129025.1

N-terminal GST

Insect (sf21)

BTN

BTN-MNK1(MKNK1)

02-445-20N

Full-length

1-424

NP_001129025.1

N-terminal DYKDDDDK

Insect (sf21)

MNK2(MKNK2)GST

MNK2(MKNK2)

02-146Full-length

1-465

NP_951009.1

N-terminal GST

Insect (sf21)

MOS

GST

MOS

05-118Full-length

1-346

NP_005363.1

N-terminal GST

Insect (sf21)

MRCKα(CDC42BPA)GST

MRCKα(CDC42BPA)

01-107

Truncated

1-574

NP_003598.2

N-terminal GST

Insect (sf21)

MRCKβ(CDC42BPB)

GST

MRCKβ(CDC42BPB)

01-108

Truncated

1-473

NP_006026.3

N-terminal GST

Insect (sf21)

MSK1(RPS6KA5)

GST

MSK1(RPS6KA5)01-147Full-length

1-802

NP_004746.2

N-terminal GST

Insect (sf21)

MAP3K5

MLK1(MAP3K9)
MLK2(MAP3K10)
MLK3(MAP3K11)
MLK4
MNK1(MKNK1)Page 7

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Serine / Threonine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
System

MSK2(RPS6KA4)

GST

MSK2(RPS6KA4)

01-148Full-length

1-772

NP_003933.1

N-terminal GST

Insect (sf21)

MSSK1(STK23)

GST

MSSK1(STK23)

04-159Full-length

1-567

NP_055185.2

N-terminal GST

Insect (sf21)

MST1(STK4)

GST

MST1(STK4)

07-116Full-length

1-487

NP_006273.1

N-terminal GST

Insect (sf21)

GST

MST2(STK3)

07-117Full-length

1-491

NP_006272.2

N-terminal GST

Insect (sf21)

BTN

BTN-MST2(STK3)

07-417-20N

Full-length

1-491

NP_006272.2

N-terminal DYKDDDDK

Insect (sf21)

MST3(STK24)

GST

MST3(STK24)

07-118Full-length

1-431

NP_001027467.2

N-terminal GST

Insect (sf21)

MST4

GST

MST4

07-119Full-length

1-416

NP_057626.2

N-terminal GST

Insect (sf21)

GST

MYLK4

02-161

Full-length

1-388

NP_001012418.2

N-terminal GST

Insect (sf21)

BTN

BTN-MYLK4

02-461-20N

Full-length

1-388

NP_001012418.2

N-terminal DYKDDDDK

Insect (sf21)

MYT1(PKMYT1)

GST

MYT1(PKMYT1)

05-176Full-length

1-499

NP_004194.3

N-terminal GST

Insect (sf21)

NDR1(STK38)

GST

NDR1(STK38)

01-125Full-length

1-465

NP_009202.1

N-terminal GST

Insect (sf21)

NDR2(STK38L)

GST

NDR2(STK38L)

01-126Full-length

1-464

NP_055815.1

N-terminal GST

Insect (sf21)
Insect (sf21)

MST2(STK3)

MYLK4

NEK1

GST

NEK1

05-123

Catalytic domain

1-505

NP_036356.1

N-terminal GST

NEK2

Tag-freeNEK205-226 (Tag-free)

Full-length

1-445

NP_002488.1

Tag-freeInsect (sf21)

NEK3

GST

NEK3

05-127Full-length

1-506

NP_002489.1

N-terminal GST

Insect (sf21)

NEK4

GST

NEK4

05-128Full-length

1-841

NP_003148.2

N-terminal GST

Insect (sf21)

NEK6

GST

NEK6

05-130Full-length

1-313

NP_055212.2

N-terminal GST

Insect (sf21)

NEK7

GST

NEK7

05-131

Full-length

1-302

NP_598001.1

N-terminal GST

Insect (sf21)

GST

NEK9

05-133

Truncated

1-346, 733-979

NP_149107.4

N-terminal GST

Insect (sf21)

BTN

BTN-NEK905-433-20N

Truncated

1-346, 733-979

NP_149107.4

N-terminal DYKDDDDK

Insect (sf21)

NEK11

GST

NEK11

05-125Full-length

1-645

NP_079076.2

N-terminal GST

Insect (sf21)

NIM1K(MGC42105)

GST

NIM1K(MGC42105)

02-175Full-length

1-436

NP_699192.1

N-terminal GST

Insect (sf21)

NLK

GST

NLK

04-151

Truncated

121-515

NP_057315.2

N-terminal GST

Insect (sf21)

NuaK1

GST

NuaK1

02-126Full-length

1-661

NP_055655.1

N-terminal GST

Insect (sf21)

GST

NuaK2

02-127Full-length

1-628

NP_112214.3

N-terminal GST

Insect (sf21)

BTN

BTN-NuaK2

02-427-20N

Full-length

1-628

NP_112214.3

N-terminal DYKDDDDK

Insect (sf21)

GST

OSR1(OXSR1)

07-122Full-length

1-527

NP_005100.1

N-terminal GST

Insect (sf21)

GST

p38α(MAPK14)

04-152

Truncated

9-352

NP_620581.1

N-terminal GST

E. coli

BTN

BTN-p38α(MAPK14)04-452-20N

Truncated

9-352

NP_620581.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-p38α(MAPK14)[inactive]

04-452-10-20N

Truncated

9-352

NP_620581.1

N-terminal DYKDDDDK

Insect (sf21)

p38β(MAPK11)

GST

p38β(MAPK11)04-153Full-length

1-364

NP_002742.3

N-terminal GST

E. colip38γ(MAPK12)GST

p38γ(MAPK12)04-155Full-length

1-367

NP_002960.2

N-terminal GST

E. colip38δ(MAPK13)

GST

p38δ(MAPK13)

04-154Full-length

1-365

NP_002745.1

N-terminal GST

E. coli

p70S6K(RPS6KB1)

GST

p70S6K(RPS6KB1)

01-156

Catalytic domain

1-421

NP_003152.1

N-terminal GST

Insect (sf21)

p70S6Kβ(RPS6KB2)

GST

p70S6Kβ(RPS6KB2)

01-155Full-length

1-482

NP_003943.2

N-terminal GST

Insect (sf21)

PAK1

GST

PAK1

07-123Full-length

1-545

NP_002567.3

N-terminal GST

Insect (sf21)

PAK2

GST

PAK2

07-124Full-length

1-524

NP_002568.2

N-terminal GST

Insect (sf21)

PAK3

GST

PAK3

07-125Full-length

1-544

NP_002569.1

N-terminal GST

Insect (sf21)

GST

PAK4

07-126Full-length

1-591

NP_005875.1

N-terminal GST

Insect (sf21)

BTN

BTN-PAK4

07-426-20N

Full-length

1-591

NP_005875.1

N-terminal DYKDDDDK

Insect (sf21)

GST

PAK5(PAK7)

07-127

Catalytic domain425-719

NP_065074.1

N-terminal GST

Insect (sf21)

GST

PAK6

07-128Full-length

1-681

NP_064553.1

N-terminal GST

Insect (sf21)

BTN

BTN-PAK6

07-428-20N

Full-length

1-681

NP_064553.1

N-terminal DYKDDDDK

Insect (sf21)

PASK

GST

PASK

02-128

Catalytic domain949-1323

NP_055963.2

N-terminal GST

Insect (sf21)

PBK

GST

PBK

05-168Full-length

1-322

NP_060962.2

N-terminal GST

Insect (sf21)

PCTAIRE1(CDK16)/CycY

GST

PCTAIRE1(CDK16)/CycY

04-116

Catalytic domain

107-496

NP_006192.1

N-terminal GST

Insect (sf21)

PDHK1(PDK1)

GST

PDHK1(PDK1)

10-123Full-length

1-436

NP_002601.1

N-terminal GST

Insect (sf21)

PDHK2(PDK2)GST

PDHK2(PDK2)

10-140Full-length

1-407

NP_002602.2

N-terminal GST

Insect (sf21)

PDHK3(PDK3)

GST

PDHK3(PDK3)

10-124Full-length

1-406

NP_005382.1

N-terminal GST

Insect (sf21)

PDHK4(PDK4)GST

PDHK4(PDK4)

10-125Full-length

1-411

NP_002603.1

N-terminal GST

E. coli

PDK1(PDPK1)

GST

PDK1(PDPK1)

01-132Full-length

1-556

NP_002604.1

N-terminal GST

Insect (sf21)

PEK(EIF2AK3)GST

PEK(EIF2AK3)

05-155

Cytoplasmic domain536-1116

NP_004827.3

N-terminal GST

E. coli

PGK(PRKG1)GSTPGK(PRKG1)

01-142Full-length

1-686

NP_006249.1

N-terminal GST

Insect (sf21)

PHKG1

GST

PHKG1

02-152Full-length

1-387

NP_006204.1

N-terminal GST

Insect (sf21)

PHKG2

GST

PHKG2

02-153Full-length

1-406

NP_000285.1

N-terminal GST

Insect (sf21)

PIM1

HIS

PIM1

02-054Full-length

1-313

NP_002639.1

N-terminal His

Insect (sf21)

PIM2

GST

PIM2

02-155Full-length

1-311

NP_006866.2

N-terminal GST

Insect (sf21)

PIM3

GST

PIM3

02-156Full-length

1-326

NP_001001852.2

N-terminal GST

Insect (sf21)

GST

PKACα(PRKACA)

01-127Full-length

1-351

NP_002721.1

N-terminal GST

Insect (sf21)

BTN

BTN-PKACα(PRKACA)

01-427-20N

Full-length

1-351

NP_002721.1

N-terminal DYKDDDDK

Insect (sf21)

PKACβ(PRKACB)GSTPKACβ(PRKACB)

01-128Full-length

1-351

NP_002722.1

N-terminal GST

Insect (sf21)

PKACg(PRKACG)

GST

PKACg(PRKACG)

01-129Full-length

1-351

NP_002723.2

N-terminal GST

Insect (sf21)

GST

PKCα(PRKCA)

01-133Full-length

1-672

NP_002728.1

N-terminal GST

Insect (sf21)

BTN

BTN-PKCα(PRKCA)

01-433-20N

Full-length

1-672

NP_002728.1

N-terminal DYKDDDDK

Insect (sf21)

PKCβ1(PRKCB1)

GST

PKCβ1(PRKCB1)

01-134Full-length

1-671

NP_997700.1

N-terminal GST

Insect (sf21)

PKCβ2(PRKCB2)

GST

PKCβ2(PRKCB2)

01-165Full-length

1-673

NP_002729.2

N-terminal GST

Insect (sf21)

GST

PKCγ(PRKCG)

01-137Full-length

1-697

NP_002730.1

N-terminal GST

Insect (sf21)

BTN

BTN-PKCγ(PRKCG)

01-437-20N

Full-length

1-697

NP_002730.1

N-terminal DYKDDDDK

Insect (sf21)

NEK9

NuaK2
OSR1(OXSR1)

p38α(MAPK14)

PAK4
PAK5(PAK7)
PAK6

PKACα(PRKACA)

PKCα(PRKCA)

PKCγ(PRKCG)

Page 8

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Serine / Threonine Kinases
Protein Kinase

Tag

Carna Product Name

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
System

PKCδ(PRKCD)

GST

PKCδ(PRKCD)

01-135Full-length

1-676

NP_006245.2

N-terminal GST

Insect (sf21)

PKCε(PRKCE)GST

PKCε(PRKCE)

01-136Full-length

1-737

NP_005391.1

N-terminal GST

Insect (sf21)

PKCζ(PRKCZ)

GST

PKCζ(PRKCZ)

01-141

Full-length

1-592

NP_002735.3

N-terminal GST

Insect (sf21)

GST

PKCη(PRKCH)

01-138Full-length

1-683

NP_006246.2

N-terminal GST

Insect (sf21)

BTN

BTN-PKCη(PRKCH)

01-438-20N

Full-length

1-683

NP_006246

N-terminal DYKDDDDK

Insect (sf21)

PKCθ(PRKCQ)GST

PKCθ(PRKCQ)

01-140Full-length

1-706

NP_006248.1

N-terminal GST

Insect (sf21)

PKCι(PRKCI)GST

PKCι(PRKCI)

01-139Full-length

1-587

NP_002731.3

N-terminal GST

Insect (sf21)

PKD1(PRKD1)GST

PKD1(PRKD1)

02-157Full-length

1-912

NP_002733.1

N-terminal GST

Insect (sf21)

PKD2(PRKD2)GST

PKD2(PRKD2)

02-158Full-length

1-878

NP_057541.2

N-terminal GST

Insect (sf21)

PKD3(PRKD3)GST

PKD3(PRKD3)

02-159Full-length

1-890

NP_005804.1

N-terminal GST

Insect (sf21)

GST

PKN1

01-144Full-length

1-942

NP_002732.3

N-terminal GST

Insect (sf21)

BTN

BTN-PKN1

01-444-20N

Full-length

1-942

NP_002732.3

N-terminal DYKDDDDK

Insect (sf21)

PKN2

GST

PKN2

01-145Full-length

1-984

NP_006247.1

N-terminal GST

Insect (sf21)

PKN3

GST

PKN3

01-146Full-length

1-889

NP_037487.2

N-terminal GST

Insect (sf21)

PKR(EIF2AK2)GST

PKR(EIF2AK2)

05-156

Catalytic domain252-551

NP_002750.1

N-terminal GST

Insect (sf21)

GST

PLK1

05-157Full-length

1-603

NP_005021.2

N-terminal GST

Insect (sf21)

PKCη(PRKCH)

PKN1

PLK1

BTN

BTN-PLK1

05-457-20N

Full-length

1-603

NP_005021.2

N-terminal DYKDDDDK

Insect (sf21)

PLK2

GST

PLK2

05-158Full-length

1-685

NP_006613.2

N-terminal GST

Insect (sf21)

PLK3

GST

PLK3

05-159Catalytic domain

58-340

NP_004064.2

N-terminal GST

Insect (sf21)

PRKX

GST

PRKX

01-130Full-length

1-358

NP_005035.1

N-terminal GST

Insect (sf21)

QIK(SNF1LK2)GST

QIK(SNF1LK2)

02-129Full-length

1-926

NP_056006.1

N-terminal GST

Insect (sf21)

GST

RAF1

09-125

Catalytic domain306-648

NP_002871.1

N-terminal GST

Insect (sf21)

BTN

BTN-RAF1

09-425-20N

Catalytic domain306-648

NP_002871.1

N-terminal DYKDDDDK

Insect (sf21)

GST

RIPK2

09-128

Catalytic domain

1-305

NP_003812.1

N-terminal GST

Insect (sf21)

GST

ROCK1

01-109Catalytic domain

1-477

NP_005397.1

N-terminal GST

Insect (sf21)

BTN

BTN-ROCK1

01-409-20N

Catalytic domain

1-477

NP_005397.1

N-terminal DYKDDDDK

Insect (sf21)

ROCK2

GST

ROCK2

01-110Catalytic domain

1-553

NP_004841.2

N-terminal GST

Insect (sf21)

RSK1(RPS6KA1)

GST

RSK1(RPS6KA1)

01-149Full-length

1-735

NP_002944.2

N-terminal GST

Insect (sf21)

RSK2(RPS6KA3)

GST

RSK2(RPS6KA3)

01-150Full-length

1-740

NP_004577.1

N-terminal GST

Insect (sf21)

RSK3(RPS6KA2)

GST

RSK3(RPS6KA2)

01-151

Full-length

1-733

NP_066958.2

N-terminal GST

Insect (sf21)

RSK4(RPS6KA6)

GST

RSK4(RPS6KA6)01-152Full-length

1-745

NP_055311.1

N-terminal GST

Insect (sf21)

SGK

GST

SGK

01-158

Truncated

61-431

NP_005618.2

N-terminal GST

Insect (sf21)

SGK2

GST

SGK2

01-159Full-length

1-367

NP_733794.1

N-terminal GST

Insect (sf21)

SGK3(SGKL)

GST

SGK3(SGKL)

01-160

Truncated

119-496

NP_037389.4

N-terminal GST

Insect (sf21)

SIK(SNF1LK)

GST

SIK(SNF1LK)

02-131

Full-length

1-783

NP_775490.2

N-terminal GST

Insect (sf21)

SIK3(QSK)GST

SIK3(QSK)

02-130Full-length

1-1369NP_001353615.1

N-terminal GST

Insect (sf21)

SIK3(QSK)(59-365aa)

GST

SIK3(QSK)(59-365aa)

02-133

Catalytic domain

59-365

NP_001353615.1

N-terminal GST

Insect (sf21)

skMLCK(MYLK2)

GST

skMLCK(MYLK2)

02-150Full-length

1-596

NP_149109.1

N-terminal GST

Insect (sf21)

SLK

GST

SLK

07-129Full-length

1-1152

NP_055535.1

N-terminal GST

Insect (sf21)

smMLCK(MYLK)

GST

smMLCK(MYLK)

02-151

Catalytic domain1428-1771

NP_444253.2

N-terminal GST

Insect (sf21)

GST

SRPK1

04-160Full-length

1-655

NP_003128.3

N-terminal GST

E. coli

BTN

BTN-SRPK1

04-460-20N

Full-length

1-655

NP_003128.3

N-terminal DYKDDDDK

Insect (sf21)

SRPK2

GST

SRPK2

04-161

Full-length

1-688

NP_872633.1

N-terminal GST

Insect (sf21)

SSTK(TSSK6)GST

SSTK(TSSK6)

02-163Full-length

1-273

NP_114426.1

N-terminal GST

Insect (sf21)

STK33

02-301 (Tag-free)

Full-length

1-514

NP_112168.1

Tag-freeInsect (sf21)

GST

STLK3(STK39)

07-130Full-length

1-545

NP_037365.2

N-terminal GST

Insect (sf21)

RAF1
RIPK2
ROCK1

SRPK1

STK33
STLK3(STK39)

Tag-freeHIS

TAK1-TAB1(MAP3K7)

09-019

Fused

1-303

NP_663304.1

N-terminal His

Insect (sf21)

BTN

BTN-TAK1-TAB1(MAP3K7)

09-419-21C

Fused

1-303

NP_663304.1

C-terminal DYKDDDDK

Insect (sf21)

TAOK2

GST

TAOK2

07-133

Catalytic domain

1-319

NP_004774.1

N-terminal GST

Insect (sf21)

TAOK3

GST

TAOK3

07-135Full-length

1-898

NP_057365.3

N-terminal GST

Insect (sf21)

GST

TBK1

05-115Full-length

1-729

NP_037386.1

N-terminal GST

Insect (sf21)

BTN

BTN-TBK1

05-415-20N

Full-length

1-729

NP_037386.1

N-terminal DYKDDDDK

Insect (sf21)

GST

TESK1

09-107Full-length

1-626

NP_006276.2

N-terminal GST

Insect (sf21)

GST

TGFβR1(TGFBR1)(ALK5)

09-141

Catalytic domain

200-503

NP_004603.1

N-terminal GST

Insect (sf21)

BTN

BTN-TGFβR1(TGFBR1)(ALK5)

09-441-20N

Catalytic domain

200-503

NP_004603.1

N-terminal DYKDDDDK

Insect (sf21)

TGFβR2(TGFBR2)GSTTGFβR2(TGFBR2)

09-142

Catalytic domain

194-567

NP_003233.2

N-terminal GST

Insect (sf21)

TLK1

GST

TLK1

05-166Full-length

1-766

NP_036422.3

N-terminal GST

Insect (sf21)

TLK2

GST

TLK2

05-167Full-length

1-750

NP_006843.2

N-terminal GST

Insect (sf21)

GST

TNIK

07-138

Catalytic domain

1-314

NP_055843.1

N-terminal GST

Insect (sf21)

BTN

BTN-TNIK

07-438-20N

Catalytic domain

1-314

NP_055843.1

N-terminal DYKDDDDK

Insect (sf21)

TAK1-TAB1(MAP3K7)

TBK1
TESK1
TGFβR1(TGFBR1)(ALK5)

TNIK
TSSK1

Tag-free

TSSK102-364 (Tag-free)

Full-length

1-367

NP_114417.1

Tag-freeInsect (sf21)

TSSK2

GST

TSSK2

02-165Full-length

1-358

NP_443732.3

N-terminal GST

Insect (sf21)

TSSK3

GST

TSSK3

02-166Full-length

2-268

NP_443073.1

N-terminal GST

Insect (sf21)

TTBK1

GST

TTBK1

03-108

Catalytic domain

1-343

NP_115927.1

N-terminal GST

Insect (sf21)

TTBK2

GST

TTBK2

03-109Catalytic domain

1-331

NP_775771.3

N-terminal GST

Insect (sf21)

TTK

GST

TTK

05-169Full-length

1-857

NP_003309.2

N-terminal GST

Insect (sf21)

ULK3

GST

ULK3

05-173Full-length

1-472

NP_001092906.1

N-terminal GST

Insect (sf21)

VRK1

GST

VRK1

03-110Full-length

1-396

NP_003375.1

N-terminal GST

E. coli

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Serine / Threonine Kinases
Protein Kinase
VRK2

Tag

CarnaProductName

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
System

GST

VRK2

03-111

Catalytic domain

1-483

NP_006287.2

N-terminal GST

Insect (sf21)

GST

WEE1

05-177

Catalytic domain215-646

NP_003381.1

N-terminal GST

Insect (sf21)

BTN

BTN-WEE1

05-477-20N

Catalytic domain215-646

NP_003381.1

N-terminal DYKDDDDK

Insect (sf21)

GST

WNK1

05-179Catalytic domain

1-491

NP_061852.1

N-terminal GST

Insect (sf21)

BTN

BTN-WNK1

05-479-20N

Catalytic domain

1-491

NP_061852.1

N-terminal DYKDDDDK

Insect (sf21)

WNK2

GST

WNK2

05-180Catalytic domain

166-489

NP_006639.3

N-terminal GST

Insect (sf21)

WNK3

GST

WNK3

05-181

Catalytic domain

1-434

NP_065973.2

N-terminal GST

Insect (sf21)

GST

WNK4

05-182

Catalytic domain

1-444

NP_115763.2

N-terminal GST

Insect (sf21)

BTN

BTN-WNK4

05-482-20N

Catalytic domain

1-444

NP_115763.2

N-terminal DYKDDDDK

Insect (sf21)

YSK1(STK25)

GST

YSK1(STK25)

07-136Full-length

1-426

NP_006365.2

N-terminal GST

Insect (sf21)

ZAK

GST

ZAK

09-120Full-length

1-455

NP_598407.1

N-terminal GST

Insect (sf21)

WEE1

WNK1

WNK4

Lipid Kinases
Protein Kinase
DGKα(DGKA)
DGKα(DGKA)(196-735aa)

DGKβ(DGKB)

DGKβ(DGKB)(235-803aa)

DGKγ(DGKG)

DGKγ(DGKG)(261-791aa)
DGKδ(DGKD)

DGKε(DGKE)

DGKη(DGKH)

DGKι(DGKI)

DGKκ(DGKK)

DGKθ(DGKQ)

DGKζ(DGKZ)MTOR(FRAP)/MLST8

Tag

CarnaProductName

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemGST

DGKα(DGKA)

12-101

Full-length

1-735

NP_958852.1

N-terminal GST

BTN

BTN-DGKα(DGKA)

12-401-20N

Full-length

1-735

NP_958852.1

N-terminal DYKDDDDK

Insect (sf21)
Insect (sf21)

BTN

BTN-DGKα(DGKA)(196-735aa)

12-411-20N

Truncated

196-735

NP_958852.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKβ(DGKB)

12-102Full-length

1-803

NP_001337638.1

N-terminal GST

Insect (sf21)

BTN

BTN-DGKβ(DGKB)

12-402-20N

Full-length

1-803

NP_001337638.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

mouse BTN-DGKβ(DGKB)

12M-402-20N

Full-length

1-802

NP_001348615.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-DGKβ(DGKB)(235-803aa)

12-412-20N

Truncated

235-803

NP_001337638.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKγ(DGKG)

12-103Full-length

1-791

NP_001337.2

N-terminal GST

Insect (sf21)

BTN

BTN-DGKγ(DGKG)

12-403-20N

Full-length

1-791

NP_001337.2

N-terminal DYKDDDDK

Insect (sf21)

BTN

mouse BTN-DGKγ(DGKG)

12M-403-20N

Full-length

1-788

NP_619591.1

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-DGKγ(DGKG)(261-791aa)

12-413-20N

Truncated

261-791

NP_001337.2

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKδ(DGKD)

12-104

Catalytic domain

1-1141

NP_690618.2

N-terminal GST

Insect (sf21)

BTN

BTN-DGKδ(DGKD)

12-404-20N

Catalytic domain

1-1141

NP_690618.2

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKε(DGKE)

12-115

Truncated protein

48-567

NP_003638.1

N-terminal GST

Insect (sf21)

BTN

BTN-DGKε(DGKE)

12-415-20N

Truncated protein

48-567

NP_003638.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKη(DGKH)

12-106

Catalytic domain

1-1147

NP_821077.1

N-terminal GST

Insect (sf21)

BTN

BTN-DGKη(DGKH)

12-406-20N

Catalytic domain

1-1147

NP_821077.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKι(DGKI)

12-107Full-length

1-1065

NP_004708.1

N-terminal GST

Insect (sf21)

BTN

BTN-DGKι(DGKI)

12-407-20N

Full-length

1-1065

NP_004708.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKκ(DGKK)

12-108

Catalytic domain

216-1271

NP_001013764.1

N-terminal GST

Insect (sf21)

BTN

BTN-DGKκ(DGKK)

12-408-20N

Catalytic domain

216-1271

NP_001013764.1

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKθ(DGKQ)

12-109Full-length

1-942

NP_001338.2

N-terminal GST

Insect (sf21)

BTN

BTN-DGKθ(DGKQ)

12-409-20N

Full-length

1-942

NP_001338.2

N-terminal DYKDDDDK

Insect (sf21)

GST

DGKζ(DGKZ)

12-110Full-length

1-929

NP_003637.2

N-terminal GST

Insect (sf21)

BTN

BTN-DGKζ(DGKZ)

12-410-20N

Full-length

1-929

NP_003637.2

N-terminal DYKDDDDK

Insect (sf21)

DYKDDDDKMTOR(FRAP)/MLST8

11-431

Catalytic domain1362-2549(MTOR),
1-326(MLST8)

NP_004949.1(MTOR),
NP_071767.3(MLST8)

N-terminal DYKDDDDK

Insect (sf21)

PI4KB

GST

PI4KB

11-131

Full-length

1-828

NP_002642.1

N-terminal GST

Insect (sf21)

PIK3C3GST

PIK3C3

11-122Full-length

1-887

NP_002638.2

N-terminal GST

Insect (sf21)

GST

PIK3CA/PIK3R1

11-101

Full-length

1-1068NP_006209.2

N-terminal GST

Insect (sf21)

BTN

BTN-PIK3CA/PIK3R1

11-401-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA [E542K]/PIK3R1

BTN

BTN-PIK3CA[E542K]/PIK3R1

11-413-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA [E545K]/PIK3R1

BTN

BTN-PIK3CA[E545K]/PIK3R1

11-414-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA [H1047R]/PIK3R1

BTN

BTN-PIK3CA[H1047R]/PIK3R1

11-415-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA [P539R]/PIK3R1

BTN

BTN-PIK3CA[P539R]/PIK3R1

11-412-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA [R88Q]/PIK3R1

BTN

BTN-PIK3CA[R88Q]/PIK3R1

11-411-20N

Full-length

1-1068NP_006209.2

N-terminal DYKDDDDK

Insect (sf21)

GST

PIK3CB/PIK3R1

11-102Full-length

1-1070

NP_006210.1

N-terminal GST

Insect (sf21)

BTN

BTN-PIK3CB/PIK3R1

11-402-20N        Full-length

1-1070

NP_006210.1

N-terminal DYKDDDDK

Insect (sf21)

GST

PIK3CD/PIK3R1

11-103Full-length

1-1044

NP_005017.3

N-terminal GST

Insect (sf21)

BTN

BTN-PIK3CD/PIK3R1

11-403-20N   

Full-length

1-1044

NP_005017.3

N-terminal DYKDDDDK

Insect (sf21)

BTN

BTN-PIK3CG

11-404-20N      Full-length

1-1102

NP_002640.2

N-terminal DYKDDDDK

Insect (sf21)

GST

PIKFYVE(PIP5K3)

11-118Full-length

1-2098NP_055855.2

N-terminal GST

Insect (sf21)

BTN

BTN-PIKFYVE(PIP5K3)

11-418-20N

Full-length

1-2098NP_055855.2

N-terminal DYKDDDDK

Insect (sf21)

PIP4K2A

GST

PIP4K2A

11-115Full-length

1-406

NP_005019

N-terminal GST

Insect (sf21)

PIP4K2B

GST

PIP4K2B

11-116Full-length

1-416

NP_003550

N-terminal GST

Insect (sf21)

PIP4K2C

GST

PIP4K2C

11-117Full-length

1-421

NP_079055

N-terminal GST

Insect (sf21)

PIP5K1A

GST

PIP5K1A

11-111

Full-length

1-549

NP_003548.1

N-terminal GST

Insect (sf21)

PIP5K1B

GST

PIP5K1B

11-112Full-length

1-540

NP_003549.1

N-terminal GST

Insect (sf21)

PIP5K1C

GST

PIP5K1C

11-113Full-length

1-668

NP_036530

N-terminal GST

Insect (sf21)

PIP5KL1GST

PIP5KL1

11-114Full-length

1-394

NP_001128691.1

N-terminal GST

Insect (sf21)

GST

SPHK1

11-105Full-length

1-384

NP_001136074.1

N-terminal GST

Insect (sf21)

BTN

BTN-SPHK1

11-405-20N

Full-length

1-384

NP_001136074.1

N-terminal DYKDDDDK

Insect (sf21)

GST

SPHK2

11-106Full-length

1-618

NP_001191089.1

N-terminal GST

Insect (sf21)

BTN

BTN-SPHK2

11-406-20N

Full-length

1-618

NP_001191089.1

N-terminal DYKDDDDK

Insect (sf21)

PIK3CA/PIK3R1

PIK3CB/PIK3R1

PIK3CD/PIK3R1
PIK3CGPIKFYVE(PIP5K3)

SPHK1

SPHK2

Page 10

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お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Inactive Kinases**Protein Kinase

Tag

CarnaProductName

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemErk2(MAPK1) [inactive]

GST

Erk2(MAPK1)[inactive]

04-143-10

Full-length

1-360

NP_002736.3

N-terminal GST

E. coliErk5(MAPK7) [inactive]

GST

Erk5(MAPK7)[inactive]

04-146-10

Catalytic domain

1-398

NP_002740.2

N-terminal GST

E. coli

JNK1(MAPK8) [inactive]

GST

JNK1(MAPK8)[inactive]

04-163-10

Catalytic domain

2-364

NP_620634.1

N-terminal GST

E. coli

JNK2(MAPK9) [inactive]

GST

JNK2(MAPK9)[inactive]

04-164-10

Catalytic domain

1-364

NP_002743.3

N-terminal GST

E. coli

GST

MAP2K1[inactive]

07-141-10

Full-length

1-393

NP_002746.1

N-terminal GST

E. coli

MAP2K1 [inactive]

BTN

BTN-MAP2K1[inactive]

07-441-10-20N

Full-length

1-393

NP_002746.1

N-terminal DYKDDDDK

Insect (sf21)

MAP2K6 [inactive]GST

MAP2K6[inactive]

07-146-10

Full-length

1-334

NP_002749.2

N-terminal GST

E. coli

MAP2K7 [inactive]GST

MAP2K7[inactive]

07-147-10

Full-length

1-419

NP_660186.1

N-terminal GST

E. colip38α(MAPK14) [inactive]GST

p38α(MAPK14)[inactive]

04-152-10

Truncated

9-352

NP_620581.1

N-terminal GST

E. coli

Inactive Mutant Kinases**Protein Kinase

Tag

CarnaProductName

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemErk2(MAPK1) [inactive mutant]

GST

Erk2(MAPK1)[inactivemutant]

04-143-11

Full-length

1-360

NP_002736.3

N-terminal GST

E. coliErk5(MAPK7) [inactive mutant]

GST

Erk5(MAPK7)[inactivemutant]

04-145-11

Catalytic domain

1-398

NP_002740

N-terminal GST

Insect (sf21)

IKKα(CHUK) [inactive mutant]

BTN

BTN-IKKα(CHUK)[inactivemutant]

05-412-11-20N

Full-length

1-745

NP_001269.3

N-terminal DYKDDDDK

Insect (sf21)

JNK1(MAPK8) [inactive mutant]

GST

JNK1(MAPK8)[inactivemutant]

04-163-11

Catalytic domain

2-364

NP_620634.1

N-terminal GST

E. coli

MAP2K1 [inactive mutant]

GST

MAP2K1[inactivemutant]

07-109-11

Full-length

1-393

NP_002746.1

N-terminal GST

Insect (sf21)

MAP2K6 [inactive mutant]

GST

MAP2K6[inactivemutant]

07-146-11

Full-length

1-334

NP_002749.2

N-terminal GST

E. coli

MAP2K7 [inactive mutant]

GST

MAP2K7[inactivemutant]

07-110-11

Full-length

1-419

NP_660186.1

N-terminal GST

Insect (sf21)

p38α(MAPK14) [inactive mutant]GST

p38α(MAPK14)[inactivemutant]

04-152-11

Truncated

9-352

NP_620581.1

N-terminal GST

E. coli** 弊社のinactive kinaseは上流のキナーゼでリン酸化されると、さらに下流の基質をリン酸化する活性を持ちます。
Inactiveと表示をしていますが、大腸菌で発現しても弱い活性を持つものはあり、弊社通常キナーゼ製品と比較して、非常に低い活性しかないことは確認しておりますが、完全に活性が無い状態ではありません。
Inactive mutant kinaseは上流のキナーゼでリン酸化はされますが、さらに下流のキナーゼをリン酸化する活性はありません。

Protein Substrates
Protein Kinase

Tag

CarnaProductName

Catalog No.

Construct

Sequence

Accession Number

Tag Location

Expression
SystemCofilin2

GST

Cofilin2

00-003Full-length

1-166

NP_068733.1

N-terminal GST

E. coli

EIF2S1GST

EIF2S100-006Full-length

1-315

NP_004085.1

N-terminal GST

E. coli

EIF4EBP1GST

EIF4EBP100-008Full-length

1-118

NP_004086.1

N-terminal GST

E. coli

Smad1

GST

Smad1

00-000Full-length

1-465

NP_005891.1

N-terminal GST

E. coli

Smad3

GST

Smad3

00-004Full-length

1-425

NP_005893.1

N-terminal GST

E. coli

Page 11

キナーゼアッセイキットリスト ～QuickScout Screening Assist® Kits～
Tyrosine Kinases
ABL(ABL1)
ABL(ABL1) [E255K]
ABL(ABL1) [T315I]
ACK(TNK2)
ALK
ALK [C1156Y]
ALK [F1174L]
ALK [G1202R]
ALK [G1269A]
ALK [L1196M]
ALK [R1275Q]
ALK [T1151_L1152insT]
EML4-ALK
NPM1-ALK
ARG(ABL2)
AXL
BLK
BMX
BRK(PTK6)BTK
BTK [C481S]
CSK
DDR1
DDR2
EGFR
EGFR [d746-750]
EGFR [d746-750/T790M]
EGFR [D770_N771insNPG]EGFR [L858R]
EGFR [L861Q]
EGFR [T790M/L858R]
EGFR [T790M]
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHA6
EPHA7
EPHA8
EPHB1
EPHB2
EPHB3
EPHB4
FAK(PTK2)
FER
FES
FGFR1
FGFR1 [V561M]
FGFR2
FGFR2 [N549H]
FGFR2 [V564I]
FGFR3
FGFR3 [G697C]
FGFR3 [K650E]
FGFR3 [K650M]
FGFR3 [V555L]
FGFR3 [V555M]
FGFR4
FGFR4 [N535K]
FGFR4 [V550E]
FGFR4 [V550L]
FGR
FLT1
FLT3
FLT4
FMS(CSF1R)FRK
FYN [isoform a]
FYN [isoform b]
HCK
HER2(ERBB2)
HER4(ERBB4)
IGF1R
INSR
IRR(INSRR)
ITK
JAK1
JAK2
JAK2(JH1 JH2)
JAK2(JH1 JH2) [V617F]
JAK3
KDR
KIT
KIT [D816E]
KIT [D816V]
KIT [D816Y]
KIT [T670I]
KIT [V560G]
KIT [V560G/D816V]
KIT [V654A]
LCK
LTK
LYNa
LYNb
MER(MERTK)MET
MET [D1228H]
MET [Ｍ1250Ｔ]
MET [Y1235D]MUSKPDGFRα(PDGFRA)PDGFRα(PDGFRA) [D842V]
PDGFRα(PDGFRA) [T674I]PDGFRα(PDGFRA) [V561D]PDGFRβ(PDGFRB)
PYK2(PTK2B)
RET
RET [G691S]
RET [M918T]
RET [S891A]
RET [Y791F]
RON(MST1R)
ROS(ROS1)SRC
SRM(SRMS)
SYK
TEC
TIE2(TEK)TNK1
TRKA(NTRK1)
TRKB(NTRK2)
TRKC(NTRK3)
TXK
TYK2
TYRO3
YES(YES1)YES(YES1) [T348I]
ZAP70

MSA

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TRFRET

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Serine/Threonine Kinases

MSA

ACTR2B (ACVR2B)
ACVR2AACVRL1(ALK1)
AKT1
AKT2
AKT3
ALK2(ACVR1)
ALK4(ACVR1B)
AMPKα1/β1/γ1(PRKAA1/B1/G1)
AMPKα2/β1/γ1(PRKAA2/B1/G1)
AurA(AURKA)
AurA(AURKA)/TPX2
AurB(AURKB)/INCENP
AurC(AURKC)
BMPR1ABMPR1B
BRAF
BRAF [V600E]
BRSK1
BRSK2
BUB1/BUB3
CaMK1α(CAMK1)
CaMK1δ(CAMK1D)
CaMK2α(CAMK2A)
CaMK2β(CAMK2B)
CaMK2δ(CAMK2D)
CaMK2γ(CAMK2G)
CaMK4
CDC2/CycB1
CDC2L6/CycC
CDC7/ASK
CDK2/CycA2
CDK2/CycE1
CDK3/CycE1
CDK4/CycD3
CDK5/p25
CDK6/CycD3
CDK7/CycH/MAT1
CDK8/CycC
CDK9/CycT1
CGK2(PRKG2)
CHK1(CHEK1)
CHK2(CHEK2)
CK1α(CSNK1A1)
CK1δ(CSNK1D)
CK1ε(CSNK1E)
CK1γ1(CSNK1G1)
CK1γ2(CSNK1G2)
CK1γ3(CSNK1G3)
CK2α1/β(CSNK2A1/B)
CK2α2/β(CSNK2A2/B)
CLK1
CLK2
CLK3
COT(MAP3K8)CRIK(CIT)DAPK1DCAMKL2
DLK(MAP3K12)DYRK1ADYRK1B
DYRK2
DYRK3
DYRK4
EEF2K
Erk1(MAPK3)
Erk2(MAPK1)
Erk5(MAPK7)
GSK3α(GSK3A)
GSK3β(GSK3B)
Haspin(GSG2)
HGK(MAP4K4)
HIPK1
HIPK2
HIPK3
HIPK4
HPK1(MAP4K1)
IKKa(CHUK)IKKβ(IKBKB)IKKε(IKBKE)
IRAK1
IRAK4
LATS2
LOK(STK10)
LZK(MAP3K13)
MAP2K1
MAP2K2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP2K7
MAP3K1
MAP3K2
MAP3K3
MAP3K4
MAP4K2
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MELK
MINK(MINK1)
MLK1(MAP3K9)
MLK2(MAP3K10)
MLK3(MAP3K11)
MNK1(MKNK1)
MNK2(MKNK2)MOS
MRCKα(CDC42BPA)MRCKβ(CDC42BPB)
MSK1(RPS6KA5)
MSK2(RPS6KA4)MSSK1(STK23)
MST1(STK4)
MST2(STK3)
MST3(STK24)
MST4
NDR1(STK38)
NDR2(STK38L)
NEK1
NEK2
NEK4
NEK6
NEK7
NEK9

FP

(IMAP™)

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ELISA

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Page 12

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TRFRET●●

Serine/Threonine Kinases
NIM1K(MGC42105)
NuaK1
NuaK2
p38α(MAPK14)p38β(MAPK11)p38γ(MAPK12)p38δ(MAPK13)
p70S6K(RPS6KB1)
p70S6Kβ(RPS6KB2)
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PASK
PBK
PDHK2(PDK2)
PDHK4(PDK4)PEK
PGK(PRKG1)
PHKG1
PHKG2
PIM1
PIM2
PIM3
PKACα(PRKACA)PKACβ(PRKACB)PKACγ(PRKACG)
PKCα(PRKCA)
PKCβ1(PRKCB1)
PKCβ2(PRKCB2)
PKCγ(PRKCG)
PKCδ(PRKCD)PKCε(PRKCE)
PKCζ(PRKCZ)
PKCη(PRKCH)
PKCθ(PRKCQ)PKCι(PRKCI)
PKD1(PRKD1)
PKD2(PRKD2)
PKD3(PRKD3)
PKR
PLK1
PLK2
PLK3
PRKX
QIK(SNF1LK2)
RAF1
ROCK1
ROCK2
RSK1(RPS6KA1)
RSK2(RPS6KA3)
RSK3(RPS6KA2)
RSK4(RPS6KA6)
SGK
SGK2
SGK3(SGKL)SIK(SNF1LK)
skMLCK(MYLK2)
SLK
SRPK1
SRPK2
TAK1-TAB1(MAP3K7)
TAOK2
TBK1
TGFβR1(TGFBR1)
TNIK
TSSK1
TSSK2
TSSK3
TTK
WEE1
WNK1
WNK2
WNK3

Lipid Kinase

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SPHK1
SPHK2
DGKα(DGKA)
DGKβ(DGKB)
DGKγ(DGKG)
DGKδ(DGKD)
DGKε(DGKE)
DGKη(DGKH)
DGKι(DGKI)
DGKθ(DGKQ)
DGKζ(DGKZ)PIK3CA／PIK3R1
PIK3CA[E542K]／PIK3R1
PIK3CA[E545K]／PIK3R1
PIK3CA[H1047R]／PIK3R1
PIK3CA[P539R]／PIK3R1
PIK3CA[R88Q]／PIK3R1
PIK3CB／PIK3R1
PIK3CD／PIK3R1
PIKFYVE(PIP5K3)
PIP4K2A
PIP4K2B
PIP5K1A
PIP5K1B
PIP5K1C
PIP5KL1

MSA

FP

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(IMAP™)

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MSA

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ELISA

TRFRET

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ADPGlo™

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MSA (Mobility Shift Assay)
FP (IMAP™)
TR-FRET
ELISA
ADP-Glo™

296
81
31
28
24

※商品詳細は別紙PRODUCT AND SERVICES 4ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

キナーゼプロファイリング・スクリーニングサービスリスト～QuickScout® Custom Profiling & Panel Profiling Series～
Tyrosine Kinases

CustomKmbin●
ABL(ABL1)●
ABL(ABL1) [E255K]●
ABL(ABL1) [T315I]●
ACK(TNK2)●
ALK●
ALK [C1156Y]●
ALK [F1174L]●
ALK [G1202R]●
ALK [G1269A]●
ALK [L1196M]●
ALK [R1275Q]●
ALK [T1151 L1152insT]●
ARG(ABL2)
●
AXL
●
BLK
●
BMX
●
BRK(PTK6)●BTK●
BTK [C481S]
●
CSK
●
DDR1
●
DDR2
●
EGFR
●
EGFR [C797S/L858R]●
EGFR [d746-750]●
EGFR [d746-750/C797S]●
EGFR [d746-750/T790M]
EGFR [d746-750/T790M/C797S ●●EGFR [D770 N771insNPG]●EGFR [L858R]●
EGFR [L861Q]●
EGFR [T790M]
EGFR [T790M/C797S/L858R]●
EGFR [T790M/L858R]●
EML4-ALK
●
EPHA1
●
EPHA2
●
EPHA3
●
EPHA4
●
EPHA5
●
EPHA6
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EPHA7
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EPHA8
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EPHB1
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EPHB2
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EPHB3
●
EPHB4
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FAK(PTK2)
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FER
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FES
●
FGFR1
●
FGFR1 [V561M]
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FGFR2
●
FGFR2 [V564I]
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FGFR3
●
FGFR3 [K650E]●
FGFR3 [K650M]●
FGFR3 [V555L]●
FGFR3 [V555M]
●
FGFR4
●
FGFR4 [N535K]●
FGFR4 [V550E]●
FGFR4 [V550L]
●
FGR
●
FLT1
●
FLT3
●
FLT4
●
FMS(CSF1R)●FRK●
FYN [isoform a]●
FYN [isoform b]●
HCK●
HER2(ERBB2)●
HER4(ERBB4)
●
IGF1R
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INSR
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IRR(INSRR)
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ITK
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JAK1
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JAK2
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JAK3
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KDR
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KIT
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KIT [D816E]●
KIT [D816V]●
KIT [D816Y]●
KIT [T670I]●
KIT [V560G]●
KIT [V654A]
●
LCK
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LTK
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LYNa
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LYNb
●
MER(MERTK)●MET●
MET [D1228H]●
MET [M1250T]●
MET [Y1235D]●
MUSK●
NPM1-ALK●PDGFRα(PDGFRA)●PDGFRα(PDGFRA) [D842V]●
PDGFRα(PDGFRA) [T674I]●PDGFRα(PDGFRA) [V561D]●PDGFRβ(PDGFRB)●
PYK2(PTK2B)●
RET●
RET [G691S]●
RET [M918T]●
RET [S891A]●
RET [Y791F]●
RON(MST1R)●
ROS(ROS1)●SRC●
SRM(SRMS)
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SYK
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TEC
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TIE2(TEK)●TNK1●
TRKA(NTRK1)●
TRKB(NTRK2)

Panel

1mM

TK

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Tyrosine Kinases
TRKC(NTRK3)
TXK
TYK2
TYRO3
YES(YES1)YES(YES1) [T348I]
ZAP70

Serine/Threonine Kinases

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AKT1
AKT2
AKT3
AMPKα1/β1/γ1(PRKAA1/B1/G1)
AMPKα2/β1/γ1(PRKAA2/B1/G1)
AurA(AURKA)
AurA(AURKA)/TPX2
AurB(AURKB)/INCENP
AurC(AURKC)
BRAF
BRAF [V600E]
BRSK1
BRSK2
BUB1/BUB3
CaMK1α(CAMK1)*
CaMK1δ(CAMK1D)
CaMK2α(CAMK2A)
CaMK2β(CAMK2B)
CaMK2γ(CAMK2G)
CaMK2δ(CAMK2D)
CaMK4
CDC7/ASK
CDK1(CDC2)/CycB1
CDK2/CycA2
CDK2/CycE1
CDK3/CycE1*
CDK4/CycD3
CDK5/p25
CDK6/CycD3
CDK7/CycH/MAT1
CDK9/CycT1
CGK2(PRKG2)
CHK1(CHEK1)
CHK2(CHEK2)
CK1α(CSNK1A1)
CK1γ1(CSNK1G1)
CK1γ2(CSNK1G2)
CK1γ3(CSNK1G3)
CK1δ(CSNK1D)
CK1ε(CSNK1E)
CK2α1/β(CSNK2A1/B)
CK2α2/β(CSNK2A2/B)
CLK1
CLK2
CLK3
COT(MAP3K8)CRIK(CIT)DAPK1DCAMKL2
DLK(MAP3K12)DYRK1ADYRK1B
DYRK2
DYRK3
EEF2K
Erk1(MAPK3)
Erk2(MAPK1)
Erk5(MAPK7)*
GSK3α(GSK3A)
GSK3β(GSK3B)
Haspin(GSG2)
HGK(MAP4K4)
HIPK1
HIPK2
HIPK3
HIPK4
HPK1(MAP4K1)
IKKα(CHUK)IKKβ(IKBKB)IKKε(IKBKE)
IRAK1
IRAK4*
JNK1(MAPK8)JNK2(MAPK9)JNK3(MAPK10)
LATS2
LOK(STK10)
MAP2K1
MAP2K2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP2K7
MAP3K1
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP4K2
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MELK
MINK(MINK1)

Custom

Km
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1mM
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Custom

Km
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Panel

1mM

STK MAPK

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Cell

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Serine/Threonine Kinases

TK

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プレインキュベーションサービスリストは14ページをご参照ください。
※商品詳細は別紙PRODUCT AND SERVICES 5～6ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。
予めご了承下さい。

Page 13

MLK1(MAP3K9)
MLK2(MAP3K10)
MLK3(MAP3K11)
MNK1(MKNK1)
MNK2(MKNK2)MOS
MRCKα(CDC42BPA)MRCKβ(CDC42BPB)
MSK1(RPS6KA5)
MSK2(RPS6KA4)MSSK1(STK23)
MST1(STK4)
MST2(STK3)
MST3(STK24)
MST4
NDR1(STK38)
NDR2(STK38L)
NEK1
NEK2
NEK4
NEK6
NEK7
NEK9
NIM1K(MGC42105)
NuaK1
NuaK2
p38α(MAPK14)p38β(MAPK11)p38γ(MAPK12)p38δ(MAPK13)
p70S6K(RPS6KB1)
p70S6Kβ(RPS6KB2)
PAK1
PAK2
PAK4
PAK5(PAK7)
PAK6
PASK
PBK
PDHK2(PDK2)
PDHK4(PDK4)
PDK1(PDPK1)PEK(EIF2AK3)
PGK(PRKG1)
PHKG1
PHKG2
PIM1
PIM2
PIM3
PKACα(PRKACA)PKACβ(PRKACB)PKACγ(PRKACG)
PKCα(PRKCA)
PKCβ1(PRKCB1)
PKCβ2(PRKCB2)
PKCγ(PRKCG)
PKCδ(PRKCD)PKCε(PRKCE)
PKCζ(PRKCZ)
PKCη(PRKCH)
PKCθ(PRKCQ)PKCι(PRKCI)
PKD1(PRKD1)
PKD2(PRKD2)
PKD3(PRKD3)PKN1
PKR(EIF2AK2)
PLK1
PLK2
PLK3
PRKX
QIK(SNF1LK2)
RAF1
ROCK1
ROCK2
RSK1(RPS6KA1)
RSK2(RPS6KA3)
RSK3(RPS6KA2)
RSK4(RPS6KA6)
SGK
SGK2
SGK3(SGKL)SIK(SNF1LK)
skMLCK(MYLK2)*
SLK
SRPK1
SRPK2
TAK1-TAB1(MAP3K7)
TAOK2
TBK1
TNIK
TSSK1
TSSK2
TSSK3
WNK1
WNK2
WNK3

Custom

Km
bin

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1mM

Panel
STK MAPK

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*ATP濃度：Km = 1mM

Lipid Kinases

SPHK1
SPHK2
DGKα(DGKA)
DGKβ(DGKB)
DGKγ(DGKG)
DGKδ(DGKD)
DGKε(DGKE)
DGKη(DGKH)
DGKι(DGKI)
DGKκ(DGKK)
DGKθ(DGKQ)
DGKζ(DGKZ)PIK3CA/PIK3R1
PIK3CA[E542K]/PIK3R1
PIK3CA[E545K]/PIK3R1
PIK3CA[H1047R]/PIK3R1
PIK3CA[P539R]/PIK3R1
PIK3CA[R88Q]/PIK3R1

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PIK3CB/PIK3R1
PIK3CD/PIK3R1
PIKFYVE(PIP5K3)
PIP4K2A
PIP4K2B
PIP5K1A
PIP5K1B
PIP5K1C
PIP5KL1

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キナーゼプロファイリング・スクリーニングターゲットリスト～QuickScout® Custom Profiling Series～
Preincubation

Tyrosine Kinases
ABL(ABL1)
ABL(ABL1) [E255K]
ABL(ABL1) [T315I]
ALK
ALK [C1156Y]
ALK [G1202R]
ALK [G1269A]
ALK [F1174L]
ALK [L1196M]
ALK [R1275Q]
ARG(ABL2)BMX
EGFR(ERBB1)
EGFR(ERBB1) [d746-750]
EGFR(ERBB1) [d746-750/C797S]
EGFR(ERBB1) [L858R]
EGFR(ERBB1) [L861Q]
EGFR(ERBB1) [T790M]
EGFR(ERBB1) [T790M/L858R]
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHA6
EPHA7
EPHA8
EPHB1
EPHB2
EPHB3
EPHB4
FER
FES
FGFR1
FGFR2
FGFR2 [V564I]
FGFR4
FGFR4 [V550L]
FLT1
FLT4
FRK
HER4(ERBB4)
IGF1R
INSR
JAK2
KDR
LCK
LYNa
LYNb
MER(MERTK)MET
MET [D1228H]
MET [M1250T]
MET [Y1235D]
NPM1-ALKPDGFRα(PDGFRA)PDGFRα(PDGFRA) [D842V]
PDGFRα(PDGFRA) [V561D]PDGFRβ(PDGFRB)

Tyrosine Kinases
PYK2(PTK2B)
RET
RET [G691S]
RET [M918T]
RET [S891A]
RET [Y791F]
RON(MST1R)
ROS(ROS1)SRC
SRM(SRMS)
TEC
TIE2(TEK)TRKB(NTRK2)
TRKC(NTRK3)TYRO3YES(YES1)YES(YES1) [T348I]

Serine/Threonine Kinases
AKT1
AKT2
AKT3
AMPKα1/β1/γ1(PRKAA1/B1/G1)
AMPKα2/β1/γ1(PRKAA2/B1/G1)
AurA(AURKA)/TPX2
AurB(AURKB)/INCENP
BRSK1
BRSK2
BUB1/BUB3
CaMK2α(CAMK2A)
CaMK2β(CAMK2B)
CaMK2γ(CAMK2G)
CaMK2δ(CAMK2D)
CaMK4CDC2(CDK1)/CycB1
CDK2/CycA2
CDK2/CycE1
CDK3/CycE1
CDK5/p25
CGK2(PRKG2)
CHK1(CHEK1)
CHK2(CHEK2)
CK1γ1(CSNK1G1)
CK1γ2(CSNK1G2)
CK1γ3(CSNK1G3)
CK1δ(CSNK1D)CK2α1(CSNK2A1)/βCK2α2(CSNK2A2)/β
CLK1
CLK2
CLK3
DYRK1ADYRK1B
DYRK2
DYRK3
Erk1(MAPK3)
Erk2(MAPK1)GSK3αSerine/Threonine Kinases
GSK3β
Haspin(GSG2)
HIPK1
HIPK2
HIPK3
IKKβ(IKBKB)
JNK1(MAPK8)JNK2(MAPK9)JNK3(MAPK10)
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARK1
MARK2
MARK3
MARK4
MNK1(MKNK1)
MNK2(MKNK2)
MSK1(RPS6KA5)
NEK2
NEK4
NIM1K(MGC42105)
Nuak1
Nuak2
p38α(MAPK14)p38β(MAPK11)p38γ(MAPK12)p38δ(MAPK13)
p70S6K(RPS6KB1)
p70S6Kβ(RPS6KB2)
PAK1
PAK2
PAK5(PAK7)
PIM1
PKCε(PRKCE)
PKD1(PRKD1)
PKD2(PRKD2)QIK(SIK2)
RSK3(RPS6KA2)
RSK4(RPS6KA6)
SGK
SGK3(SGKL)
skMLCK(MYLK2)
TBK1
TSSK1

Lipid Kinase
SPHK1
Tyrosine Kinases 76
Serine/Threonine Kinases 84
Lipid Kinase 1
Total 161 targets※商品詳細は別紙PRODUCT AND SERVICES 5ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 14

カイネティクス測定アッセイ ～Phosphosens™～ ターゲットリスト
Tyrosine Kinases
ABL1

CSK

EPHA6

FGFR4

LCK

RET [Y791F]

ABL1 [E255K]

DDR1 (SRC treated)

EPHA7

FGR

LTK

RET:CCDC6 (CCDC6‐RET)ABL1 [T315I]

DDR2

EPHA8

FLT1

LYNa

ROS1 (ROS)ABL2 (ARG)

EGFR (ERBB1)

EPHB1

FLT3

LYNb

ROS1 [G2032R]

ALK

EGFR (D770_N771insNPG)

EPHB2

FLT4

MERTK (MER)SRC

ALK [C1156Y]

EGFR [C797S/L858R]

EPHB3

FRK

MET (c‐MET, HGFR)SRMS (SRM)

ALK [F1174L]

EGFR [d746‐750/C797S/T790M]

EPHB4

FYNa

MST1R (RON)SYKALK [G1269A]

EGFR [d746‐750/C797S]

ERBB2 (HER2)

FYNb

MUSK

TEC

ALK [G1202R]

EGFR [d746‐750/T790M]

ERBB2 (HER2)[A775/G776insYVMA]HCKNTRK1 (TRKA)

TEK (TIE2)

ALK [L1196M/G1202R]

EGFR [d746‐750]

ERBB4 (HER4)

IGF1R

NTRK2 (TRKB)TNK2 (ACK)ALK [L1196M]

EGFR [L858R]

FER

INSR (IR)NTRK3 (TRKC)TXKALK [R1275Q]

EGFR [L861Q]

FES

INSRR (IRR)

PDGFRA (PDGFRα)TYK2 [JH1]

ALK [T1151‐L1152 INS T]

EGFR [T790M/C797S/L858R]

FGFR1

ITK

PDGFRB (PDGFRβ)TYRO3

ALK:NPM1 (NPM1‐ALK)EGFR [T790M/L858R]

FGFR2

JAK1 [JH1]

PTK2 (FAK)

YES1 (YES)AXL

EGFR [T790M]

FGFR3

JAK1 [JH1‐JH2]

PTK2B (PYK2)

ZAP70

BLK

EPHA1

FGFR3 [G697C]

JAK2 [JH1]

PTK6 (BRK)

BMX

EPHA2

FGFR3 [K650E]

JAK2 [JH1‐JH2]

RET

BTK

EPHA3

FGFR3 [K650M]

JAK3 [JH1]

RET [G691S]

BTK [C481S]

EPHA4

FGFR3 [V555L]

KDR (VEGFR2)

RET [M918T]

CSF1R (FMS)EPHA5

FGFR3 [V555M]

KIT

RET [S891A]

AKT1 (PKB)

CLK1

ICK

MARK1

PKN1

AKT2 (PKBβ)CLK2IKKB (IKKβ)

MARK2

PKN2

AKT3 (PKBγ)

CLK3

IKKE (IKKe)

MARK3

PKN3

RPS6KB2 (p70S6KB)AURKA (AURA)CSNK1A1 (CK1A1, CK1α)

IRAK1

MARK4

PLK1

SBK1 (SBK)AURKB (AURB)CSNK1A1L (CK1A1L, CK1α2)

IRAK4

MASTL

PLK3

SGK1 (SGK)AURKC (AURC)CSNK1D (CK1D, CK1δ)

KSR1

MELK

PLK4

SGK2

BRSK1

CSNK1E (CK1E, CK1ε)KSR2MINK1 (ZC3)PNCK (CAMK1β)

SGK3

BRSK2

CSNK1G1 (CK1G1, CK1γ1)

LATS1

MKNK1 (MNK1)PRKAA1‐B1‐G1 (AMPKα1β1γ1)

SIK1 (SIK)

BUB1

CSNK1G2 (CK1G2, CK1γ2)

LATS2

MKNK2 (MNK2)PRKAA1‐B2‐G1 (AMPKα1β2γ1)

SIK2 (QIK)CAMK1A (CAMK1α)CSNK1G3 (CK1G3, CK1γ3)LRRK2

MYLK (MLCK)PRKAA2‐B1‐G1 (AMPKα2β1γ1)

SIK3 (QSK)CAMK1D (CAMK1δ)CSNK2A1 (CK2A1, CK2α1)

LRRK2 [G2019S]

MYLK2

PRKAA2‐B2‐G1 (AMPKα2β2γ1)

SLK

CAMK1G (CAMK1γ)

CSNK2A2 (CK2A2, CK2α2)

MAK

MYO3A

PRKACA (PKACα)SNRKCAMK2A (CAMK2α)

DAPK1

MAP2K1 (MEK1), Cascade

MYO3B

PRKACB (PKACβ)SRPK1

CAMK2B (CAMK2β)DAPK2 (DRP‐1)

MAP2K1 (MEK1), Direct

NEK1

PRKACG (PKACG, PKACg)

SRPK2

CAMK2D (CAMK2δ)DAPK3 (ZIPK)

MAP2K2 (MEK2), Cascade

NEK2

PRKCA (PKCα [alpha])

SRPK3 (MSSK1)

CAMK2G (CAMK2γ)

DCLK1 (DCAMKL1)

MAP2K2 (MEK2), Direct

NEK3

PRKCB1 (PKCβ1 [beta1])

STK3 (MST2)

CAMK4

DCLK2 (DCAMKL2)

MAP3K1 (MEKK1)NEK4PRKCB2 (PKCβ2 [beta2])

STK4 (MST1)CAMKK1

DYRK1A

MAP3K2 (MEKK2)NEK5PRKCD (PKCδ [delta])

STK10 (LOK)CDC42BPB (MRCKB)DYRK1B

MAP3K3 (MEKK3)NEK7PRKCE (PKCe [epsilon])

STK11 (LKB1, AMPKK)CDC42BPG (DMPK2)DYRK2MAP3K5 (ASK1)NEK9PRKCG (PKCγ [gamma])

STK17A (DRAK1)

CDK1/CycB1(CDC2)DYRK3MAP3K8 (Tpl2, COT)NEK10PRKCH (PKCη [eta])

STK17B (DRAK2)

CDK1/CycE1

DYRK4

MAP3K9 (MLK1)

NIM1 (NIM1K)PRKCI (PKCι [iota])

STK24 (MST3)

CDK2/CycA2

EEF2K (eEF2K)

MAP3K11 (MLK3)NLK (LAK1)PRKCQ (PKCθ [theta])

STK25 (YSK1)CDK2/CycE1

EIF2AK1 (HRI)

MAP3K19 (YSK4)NUAK1 (ARK5)

PRKCZ (PKCζ [zeta])

STK26 (MST4)

CDK3/CycE1

EIF2AK2 (PKR), Full length

MAP3K20 (MLK7, ZAK)

NUAK2 (SNARK)PRKD1 (PKD1)

STK38 (NDR1)

CDK4/CycD3

EIF2AK3 (PERK/PEK)

MAP4K1 (HPK1)

PAK1

PRKD2 (PKD2)

STK38L (NDR2)

CDK5/p25

EIF2AK4 (GCN2)

MAP4K2 (GCK)

PAK2

PRKD3 (PKD3)

TAOK1 (TAO1)

CDK5/p35

ERN1 (IRE1)

MAP4K3 (GLK, KHS2)PAK3PRKDC (DNA‐PK)

TAOK2 (TAO2)

CDK6/CycD1

ERN2 (IRE2)

MAP4K4 (HGK, ZC1)

PAK4

PRKG1 (PKG1, PGK)TAOK3 (TAO3)

CDK6/CycD3

FAM20C

MAP4K5 (KHS1)

PAK5 (PAK7)

PRKG2 (PKG2, PGK2, CGK2)

TBK1

CDK7/CycH/MAT1

GRK1 (RHOK)MAPK1 (ERK2)

PAK6

PRKX

TNIK (ZC2)

CDK9 (TAK) w/CycK

GRK2 (ADRBK1, BARK1)

MAPK3 (ERK1)PBK (TOPK)

Raf, b‐ (V600E), Cascade

TRPM7 (CHAK1)

CDK9 (TAK) w/CycT1

GRK3 (ADRBK2, BARK2)

MAPK7 (ERK5)

PDK1 (PDHK1)

Raf, b‐ (V600E), Direct

TSSK1B (TSSK1)

CDK14 (PFTAIRE1)/CycY

GRK4 (GPRK4)

MAPK8 (JNK1)

PDK2 (PDHK2)

RAF1 (Y340E/Y341E), Cascade

TSSK2

CDK16/CycY

GRK5 (GPRK5)

MAPK9 (JNK2)

PDK3 (PDHK3)

RAF1 (Y340E/Y341E), Direct

TSSK3

CDK17 (PCTAIRE2)/CycY

GRK7 (GPRK7)

MAPK10 (JNK3)

PDK4 (PDHK4)

RIPK2

TTK

CDK18/CycY (PCTAIRE3)

GSK3A (GSK3α)

MAPK11 (p38β)

PDPK1 (PDK1)

ROCK1

TTBK1

CDPK1 (toxoplasma gondii)

GSK3B (GSK3β)

MAPK12 (p38γ)

PHKG1

ROCK2

TTBK2

CDPK3 (toxoplasma gondii)

HASPINMAPK13 (p38δ)PHKG2

RPS6KA1 (RSK1)

ULK1

CHEK1 (CHK1)

HIPK1

MAPK14 (p38α)

PIM1

RPS6KA2 (RSK3)

ULK2

CHEK2 (CHK2)HIPK2MAPKAPK2 (MK2)PIM2

RPS6KA3 (RSK2)CHUK (IKKA, IKKα)HIPK3MAPKAPK3 (MK3)PIM3

RPS6KA4 (MSK2)

CIT (CRIK)HIPK4MAPKAPK5 (MK5)PINK1 (PINK)RPS6KA5 (MSK1)

PTPN2 (TCPTP, PTPT)PTPN2 (TCPTP, PTPT)PTPN4 (MEG1)
PTPN5 (STEP)PTPN6 (SHP‐1, PTP-1C)

PTPN7 (HEPTP, LC-PTP)
PTPN9 (MEG2)
PTPN11 (SHP‐2, PTP2C, PTP1D)PHLPP1 (PHLPP, SCOP)PHLPP2 (PHLPPL)

PPM1D (WIP1, PP2C-delta)
PPM1F (CamKPase)

PPM1A (PP2Cα, PP2CA)

PPM1G (PP2Cγ)

CDC25A

CDC25B

Serine/Threonine Kinases
RPS6KA6 (RSK4)RPS6KB1 (p70S6K)

Tyrosine Phosphatase

PTPN12 (PTP-PEST, PTPG1)
PTPN13 (FAP-1, PTP-BAS, PTP-E1, PNP1)

PTPN22 (PTPN8, Lyp)PTPRA (R-PTP-alpha, PTPA, LRP)PTPRB (R-PTP-beta, VEPTP)
PTPRC (L-CA, CD45, T200)
PTPRE (R-PTP-epsilon)

PTPRF (LAR)
PTPRG (R-PTP-gamma)
PTPRJ (R-PTP-eta, DEP1, CD148)
PTPRM (PTPµ, PTPRL1, RPTP-mu)
PTPRS (R-PTP-sigma)

Serine / Threonine Phosphatase
PPP1CA (PP1A/PPP1A)
PPP1CB (PP1B, PPP1B)
PPP2CA (PP2A‐α, RP-C)

PPP2CB (PP2Abeta)
PPP3CA/B (Calcineurin A/B,
CNA alpha/beta, CALNA/B)

Dual Phosphatase
CDC25CDUSP3 (VHR)

DUSP22 (JSP-1, LMW-DSP2, MKPX)

赤文字：PhosphoSens™ REDでの利用可※商品詳細は別紙PRODUCT AND SERVICES 7ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 15

キナーゼ蛋白質相互作用解析 ～Residence Timer™～ ターゲットリスト
KinaseABL(ABL1)
ACVR2A
AKT1
AKT2
ALK
ALK [C1156Y]
ALK [F1174L]
ALK [F1174L／G1202R]
ALK [G1202R]
ALK [G1269A]
ALK [I1171N]
ALK [I1171N／L1198F]
ALK [I1171S]
ALK [I1171T]
ALK [L1196M]
ALK [L1196M／G1202R]
ALK [L1198F]
ALK [R1275Q]
ALK [V1180L]AMPKα1/β1/γ1
AMPKα1/β2/γ1
AurA (AURKA)
AurB(AURKB)／INCENP *
AXL
BMX
BRAF
BRK(PTK6) *BTK *BTK[non-activated]
BTK [C481S] *BTK [C481S][non-activated]
BTK [T316A] *BTK [T316A][non-activated]
BTK [T474I] *BTK [T474I][non-activated]
BTK [T474S] *BTK [T474S][non-activated]
CaMK2β(CAMK2B)
CaMK2δ(CAMK2D)
CDK1(CDC2)／CycA2
CDK1(CDC2)／CycB1
CDK2／CycA2
CDK2／CycE1
CDK3／CycE1
CDK4／CycD1
CDK4／CycD3
CDK5／p25
CDK6／CycD1
CDK6／CycD3
CDK6／CycD3[non-activated]
CDK7／CycH／MAT1
CDK8／CycC
CDK9／CycKCDK9／CycT1
CDK9／CycT2
CHK1(CHEK1)
DDR1
DDR2 *EGFR
EGFR [C797S]
EGFR [C797S／L858R]
EGFR [d746-750]
EGFR [d746-750／C797S]
EGFR [d746-750／T790M／C797S／L858R]

EGFR [L858R]
EGFR [T790M]
EGFR [T790M／L858R]
EPHA2
FAK(PTK2)
FGFR1 *
FGFR1[non-activated]
FGFR2 *
FGFR2[non-activated]
FGFR2 [C491A/V564I] *FGFR2 [C491A] *FGFR2 [C491A][non-activated]
FGFR2 [C491A／V564I][non-activated]

FGFR2 [N549H] *FGFR2 [N549H][non-activated]
FGFR2 [V564I] *FGFR2 [V564I][non-activated]
FGFR2 [V564L] *FGFR2 [V564L][non-activated]
FGFR3 *FGFR4
FLT3 *
FLT3 [non-activated]
FMS(CSF1R)[non-activated]
FMS(CSF1R) *FYN [isoform a]
GCN2(EIF2AK4)

Kinase

対象化合物として評価可能薬剤

GSK3β(GSK3B)
HPK1(MAP4K1)
IGF1R *
IGF1R[non-activated]
IKKα(CHUK) *IKKα(CHUK)[inactive mutant]
INSR *
INSR[non-activated]
IRAK4
ITK *
JAK2
KDR(VEGFR2)
KIT *LATS2／MOBKL1A
LCK
LIMK2
LYNa
MAP2K1[inactive]
MAP3K5
MER(MERTK)MET
MET [D1228H]
MET [D1228N]
MET [M1250T]
MET [Y1230C]
MET [Y1230H]
MLK1(MAP3K9)
MLK2(MAP3K10)
MLK3(MAP3K11)
MST2(STK3)
MYLK4
Nuak2
p38α(MAPK14)p38α(MAPK14)[inactive]
PAK4
PAK6
PDGFRα(PDGFRA) *PDGFRα(PDGFRA)[non-activated]
PDGFRβ(PDGFRB) *PDGFRβ(PDGFRB)[non-activated]
PIK3CA／PIK3R1
PIK3CA [E542K]／PIK3R1
PIK3CA [E545K]／PIK3R1
PIK3CA [H1047R]／PIK3R1
PIK3CA [P539R]／PIK3R1
PIK3CA [R88Q]／PIK3R1
PIK3CB／PIK3R1
PIK3CD／PIK3R1
PIK3CGPIK3CG/PIK3R5PIKFYVE(PIP5K3)
PKACα(PRKACA)
PKCα(PRKCA)
PKCη(PRKCH)
PKN1
PLK1
PYK2(PTK2B) *RAF1 (CRAF)
RET
RET [G691S] *RET [G691S][non-activated]
RET [M918T] *RET [M918T][non-activated]
RET [S891A] *RET [S891A][non-activated]
RET [V804M] *RET [V804M][non-activated]
RET [Y791F] *RET [Y791F][non-activated]
ROCK1
SPHK1
SRC
SRPK1
SYK *
SYK[non-activated]
TBK1
TGFβR1(TGFBR1)
TIE2(TEK) *TNIK
TRKA(NTRK1) *TRKA(NTRK1)[non-activated]
TRKB(NTRK2) *TRKB(NTRK2)[non-activated]
TRKC(NTRK3) *TYRO3 *
TYRO3[non-activated]
WEE1
WNK1
WNK4
YES(YES1)

abemaciclib, staurosporine
bosutinib
GSK-1838705, staurosporine, cabozantinib
brigatinib
IKKβ inhibitor
IKKβ inhibitor
BMS-754807, ceritinib, GSK1838705A, linsitinib, NVP-ADW742
BMS-754807, ceritinib, GSK1838705A, linsitinib, NVP-ADW742
crizotinib, sunitinib
crizotinib, sunitinib
staurosporine
vandetanib
pazopanib, masitinib, staurosporine
staurosporine
ponatinib, regorafenib
dasatinib
ponatinib, regorafenib, tamatinib
crizotinib, dasatinib, trametinib
staurosporine, bosutinib, sunitinib
BMS-777607
crizotinib
foretinib
foretinib
MET/RON inhibitor
crizotinib
MET/RON inhibitor
bosunitib, dabrafenib, midostaurin, sunitinib
bosunitib, dabrafenib, midostaurin, sunitinib
bosunitib, dabrafenib, midostaurin, sunitinib
midostaurin
dovitinib
staurosporine
sorafenib, p38 MAPK inhibitors
sorafenib, p38 MAPK inhibitors
GSK690693, staurosporine, bosutinib
staurosporine
nintedanib, axitinib, crenolanib, gilteritinib
nintedanib, axitinib, crenolanib, gilteritinib
nintedanib, axitinib, crenolanib, gilteritinib
nintedanib, axitinib, crenolanib, gilteritinib
pictilisib, dactolisib
idelalisib
idelalisib
idelalisib
idelalisib
idelalisib
apitolisib
idelalisib, duvelisib
apitolisib, dactolisib, duvelisib
apitolisib, duvelisib
YM201636
A-674563
A-674563, enzastaurin, sotrastaurin
staurosporine
GSK690693
GSK461364
crizotinib
dabrafenib
ponatinib, regorafenib, vandetanib, dasatinib, sorafenib
staurosporine
cabozantinib
staurosporine
staurosporine
staurosporine
quizartinib
staurosporine
staurosporine
staurosporine
cediranib
GSK-429286A
PF-543 citrate
A-770041, ponatinib, regorafenib
staurosporine
staurosporine
staurosporine
staurosporine
SB 431542
ponatinib, vandetanib
bosutinib, sunitinib
AZ23, ponatinib
AZ23, ponatinib
AZ23, ponatinib
ponatinib
AZ23, sorafenib
BMS-777607
BMS-777607
AZD1775
WNK463WNK463
staurosporine, saracatinib

対象化合物として評価可能薬剤
ponatinib, bosutinib, dasatinib, imatinib
dasatinib
GSK690693
GSK690693
alectinib, crizotinib
GSK1838705
crizotinib
brigatinib
lorlatinib
brigatinib
brigatinib
brigatinib
ceritinibbrigatinib
brigatinib, crizotinib
TAE684gilteritinib
brigatinib
TAE684
fasudil, GSK690693, TAE684, WZ4003
GSK690693, WZ4003
MK-5108, pan-Aurora inhibitors
MK-5108, pan-Aurora inhibitors
crizotinib, sunitinib
bosutinib, dasatinib
dabrafenib, vemurafenib
ibrutinib
ponatinib, ibrutinib, dasatinib
ponatinib, ibrutinib, dasatinib
fenebrutinib
fenebrutinib, ibrutinib
fenebrutinib, ibrutinib
fenebrutinib, acalabrutinib
ARQ-531, ibrutinib
ibrutinib
ARQ-531, ibrutinib
ibrutinib
midostaurin
sunitinib
staurosporine
AT7519, dinaciclib, flavopiridol, PHA-793887, PHA-848125
PHA-793887, dinaciclib
SNS-032
AT7519dinaciclib
dinaciclib, palbociclib, ribociclib, abemaciclib
SNS-032, dinaciclib
dinaciclib
ribociclib
ribociclib
dinaciclib, pan-CDK inhibitorsstaurosporine
PHA-739887, dinaciclib
dinaciclib, pan-CDK inhibitorsstaurosporine, dinaciclib
bosutinib, sunitinib
imatinib
ponatinib, dasatinib, imatinib, sorafenib
afatinib, erlotinib, gefitinib
afatinibafatinib, erlotinib, gefitinib
gefitinib, erlotinib, afatinib
gefitinib, erlotinib, afatinib
brigatinib
afatinibafatinib
osimertinib
BMS-777607, dasatinib, staurosporine,
crizotinib
infigratinib, ponatinib
infigratinib, ponatinib
ponatinib
ponatinib
dovitinib
ponatinib
ponatinib
ponatinib
axitinib
axitinib
axitinib
axitinib
axitinib
axitinibinfigratinib, sunitinib
infigratinib, sunitinib
imatinib, dasatinib
crenolanib, gilteritinib, midostaurin, sunitinib
dasatinib
dasatinib
dasatinib, ponatinib, regorafenib
A-92* 精製後活性向上の為ATP処理を施しているキナーゼ蛋白質※商品詳細は別紙PRODUCT AND SERVICES 8ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 16

NanoBRET™ TE Intracellular Kinase キナーゼセルべースアッセイターゲットリスト
青字のターゲットは当社にて評価済のものです。
青字以外のターゲットの納期につきましてはお問い合わせ下さい。

Kinase Name
AAK1

CDK7

FAK(PTK2)

LIMK2

NLK

RSK3(RPS6KA2)

ABL1(ABL)

CDK7／Cyc H

FER

LRRK2

NRK

RSK4(RPS6KA6)

ABL1(ABL) [E255K]

CDK8／Cyc CFESLRRK2 [G2019S]

NUAK1(ARK5)

SBK3

ABL1(ABL) [F317I]

CDK9／Cyc K

FGFR1

LRRK2 [I2020T]

NUAK2

SGK1(SGK)ABL1(ABL) [F317L]

CDK9／Cyc T1

FGFR2

LRRK2 [R1441C]

PAK4

SGK2

ABL1(ABL) [H396P]

CDK10／Cyc L2

FGFR2 [K659M]

LTK

PAK6

SIK1(SIK)

ABL1(ABL) [M351T]

CDK11A／Cyc K

FGFR2 [L617F]

LYN

PAK7(PAK5)

SIK2(QIK, SNF1LK2)

ABL1(ABL) [Q252H]

CDK11A／Cyc L2

FGFR2 [L617V]

MAP2K5(MEK5)PDGFRA [V561D]

SIK3(QSK)ABL1(ABL) [T315I]

CDK12／Cyc K

FGFR2 [M537I]

MAP2K6

PHKG1

SLKABL1(ABL) [Y253F]

CDK13／Cyc K

FGFR2 [N549H]

MAP3K2

PHKG2

SNRK

ABL2(ARG)

CDK14／Cyc Y

FGFR2 [N549K]

MAP3K3

PI4KA

SRC

ACVR1(ALK2)

CDK15／Cyc Y

FGFR2 [V564F]

MAP3K4PI4KB

SRMS(SRM)

ACVR1(ALK2) [G328V]

CDK16(PCTAIRE1)／CycY

FGFR2 [V564I]

MAP3K9(MLK1)PIK3C3

STK3(MST2)

ACVR1(ALK2) [G356D]

CDK17／Cyc Y

FGFR3

MAP3K10(MLK2)PIK3CA／PIK3R1

STK4(MST1)

ACVR1(ALK2) [Q207D]

CDK18／Cyc Y

FGFR3 [G380R]

MAP3K11(MLK3)PIK3CA [C420R]／PIK3R1

STK10(LOK)ACVR1(ALK2) [R206H]

CDK19／Cyc C

FGFR3 [G697C]

MAP3K12(DLK)PIK3CA [E542K]／PIK3R1

STK11

ACVRL1(ALK1)

CDK20／Cyc H

FGFR3 [V555M]

MAP3K13(LZK)PIK3CA [E545A]／PIK3R1

STK16

ADK

CDKL1

FGFR4

MAP3K19

PIK3CA [E545K]／PIK3R1

STK17A(DRAK1)

AKT1

CDKL2

FGR

MAP3K21(MLK4)PIK3CA [H1047L]／PIK3R1

STK17B

AKT1 [E17K]

CDKL3

FLT1

MAP4K1(HPK1)PIK3CA [H1047R]／PIK3R1

STK24(MST3)

AKT2

CDKL5

FLT3

MAP4K2PIK3CA [H1047Y]／PIK3R1

STK26(MST4)

AKT2 [E17K]

CHEK1(CHK1)

FLT3 [D835H]

MAP4K3

PIK3CA [I800L]／PIK3R1

STK32A

AKT3 [E17K]

CHEK2(CHK2)

FLT3 [D835V]

MAP4K5PIK3CA [M1043I]／PIK3R1

STK32B

AKT3 [G171R]

CLK1

FLT3 [D835Y]

MAPK4PIK3CA [Q546K]／PIK3R1

STK33

ALK

CLK2

FLT3 [K663Q]

MAPK6

PIK3CB／PIK3R1

STK35

ALK4(ACVR1B)

CLK4

FLT3 [N841I]

MAPK11(p38β)

PIK3CD／PIK3R1

STK36

AURKA

COQ8B

FLT3 [R834Q]

MAPK14(p38α)

PIK3CGSTK38(NDR1)AURKBCRAF(RAF1)

FRK

MAPK14(p38α) [T106M]

PIKFYVE(PIP5K3)

STK38L(NDR2)

AURKC

CSF1R(FMS)

FYN

MARK2

PIM3

TBK1

AXL

CSK

FYN [Y531F]

MARK3

PIP4K2CTEC

BLK

CSNK1A1L

GAK

MARK4

PIP5K1B

TEK(TIE2)

BMP2K

CSNK1D(CK1δ)GSK3A(GSK3α)

MAST3PKACα(PRKACA)TEK(TIE2) [A1124V]

BMPR1ACSNK1E(CK1ε)GSK3B(GSK3β)

MAST4PKACβ(PRKACB)TEK(TIE2) [P883A]

BMX

CSNK1G2(CK1γ2)

HCK

MELK

PKCα(PRKCA)TEK(TIE2) [R849W]

BRAF

CSNK2A1(CK2α1)

HIPK2

MELK [T460M]

PKCβ1(PRKCB1)TEK(TIE2) [Y1108F]

BRAF [V600E]

CSNK2A2(CK2α2)

HIPK3

MER(MERTK)

PKCγ(PRKCG)TEK(TIE2) [Y897C]

BRK(PTK6)

DAPK2

HIPK4

MER(MERTK) [A708S]

PKCδ(PRKCD)TEK(TIE2) [Y897S]

BRSK1

DCLK1(DCAMKL1) [isoform1]

ICK

MET

PKCε(PRKCE)

TESK1

BRSK2

DCLK1(DCAMKL1) [isoform2]

IGF1R

MET [D1228H]

PKCη(PRKCH)TGFBR1(ALK5)

BTK

DCLK3

IKBKE(IKKε)MET [D1228N]

PKCθ(PRKCQ)TGFBR2

BTK [C481S]

DDR1

INSR

MET [F1200I]

PKMYT1(MYT1)

TIE1

BTK [E41K]

DDR2

IRAK1

MET [M1250T]

PLK1

TLK1

BTK [L528W]

DDR2 [N456S]

IRAK3

MET [P991S]

PLK2

TLK2

BTK [P190K]

DYRK1AIRAK4

MET [T1173I]

PLK3

TNK1

BTK [T474I]

DYRK1BITK

MET [T992I]

PLK4

TNK2(ACK)CAMK1(CaMK1α)

DYRK2

JAK1

MET [V1092I]

PNCK(CaMK1β)

TNNI3K(HH498)

CAMK1D(CaMK1δ)EGFR

JAK1_JH2 Domain

MET [Y1230A]

PRKAA1(AMPKα1)

TRKA(NTRK1)

CAMK1G(CaMK1γ)

EGFR [d746-750]

JAK2

MET [Y1230C]

PRKAA2(AMPKα2)

TRKA(NTRK1) [G667C]

CAMK2A(CaMK2α)

EGFR [L858R]

JAK2 [V617F]

MET [Y1230D]

PRKG2(CGK2)

TRKB(NTRK2)

CAMK2D(CaMK2δ)EGFR [T790M／L858R]

JAK2_JH1 Domain

MET [Y1230H]

PRKX

TSSK1BCAMK2G(CaMK2γ)

EIF2AK4(GCN2)_Domain2

JAK3

MET [Y1235D]PYK2 (PTK2B)TTKCAMKK1(124-411)

EPHA1

JNK1(MAPK8)MKNK2(MNK2)

RET

TXK

CAMKK2(165-445)

EPHA2

JNK2(MAPK9)MLTK(ZAK)

RET [M918T]

TYK2

CDK1／Cyc A2(CDC2／CycA2)

EPHA3

JNK3(MAPK10)

MOK

RET [V804L]

TYK2_JH1 Domain

CDK1／Cyc B1(CDC2／CycB1)

EPHA4

KDR(VEGFR2)

MUSK

RET [V804M]

TYK2_JH2 Domain

CDK1／Cyc E1(CDC2／CycE1)

EPHA5

KIT

MYLK2(skMLCK)

RIOK2

TYRO3

CDK2／Cyc A1

EPHA6

KIT [A829P]

MYLK3

RIPK1

ULK1

CDK2／Cyc A2

EPHA7

KIT [D816H]

MYLK4

RIPK2

ULK2

CDK2／Cyc E1

EPHA8

KIT [D816V]

NEK1

RIPK3

ULK3

CDK3／Cyc E1

EPHB1

KIT [L576P]

NEK2

ROCK1

WEE1

CDK4／Cyc D1

EPHB2

KIT [V559D]

NEK3

ROCK2

WEE2

CDK4／Cyc D3

EPHB3

KIT [V559D,T670I]

NEK4

RON

YES1(YES)

CDK5

EPHB4

KIT [V559D,V654A]

NEK5

RPS6KA4(MSK2)

CDK5／CDK5R1

ERK1(MAPK3)

LATS1

NEK6

RSK1(RPS6KA1)

CDK5／CDK5R2

ERK2(MAPK1)

LATS2

NEK9

RSK2(RPS6KA3)

CDK6／Cyc D1

ERN1

LCK

NEK11

RSK2(RPS6KA3) [I416V]

CDK6／Cyc D3

ERN2

LIMK1

NIM1K(MGC42105)

RSK2(RPS6KA3) [L608F]※商品詳細は別紙PRODUCT AND SERVICES 9ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 17

NanoBRET™ TE Intracellular Kinase キナーゼセルべースアッセイ【パネルアッセイサービス】～ ＣＤＫパネルアッセイサービス ～Kinase Name

CDK1(CDC2)／CycB1

CDK5／CDK5R1

CDK9／CycT1

CDK15／CycY

CDK2／CycA1

CDK6／CycD1

CDK10／CycL2

CDK16／CycY

CDK2／CycE1

CDK6／CycD3

CDK11A／CycL2

CDK17／CycY

CDK3／CycE1

CDK7／CycH

CDK12／CycK

CDK18／CycY

CDK4／CycD1

CDK8／CycC

CDK13／CycK

CDK19／CycC

CDK4／CycD3

CDK9／CycKCDK14／CycY

CDK20／CycH～ Kinome-Wide Profiling Service (K192) ～Kinase Name
AAK1

DCLK3

LTK

PHKG2

ACK (TNK2)DLK (MAP3K12)

MAP3K2PKACα (PRKACA)

AKT2

DRAK2 (STK17B)

MAP3K3PKACβ (PRKACB)AMPKα1 (PRKAA1)

DYRK1A

MAP3K4PKCε (PRKCE)AMPKα2 (PRKAA2)

DYRK1B

MAP3K19

PLK2

ARG (ABL2)

EPHA1

MAP4K2PLK3AurA (Aurora A)
AurB (Aurora B)

EPHA4
EPHA6

MAP4K3
MAP4K5PLK4PRKX

AurC (Aurora C)

EPHA7

MAPK4

PYK2 (PTK2B)

AXL

EPHB1

MAPK6

QIK (SIK2)

BMP2K

EPHB4

MARK2

RET

BMX

ERN1

MARK4

RIOK2

BRAF[V600E]

ERN2

MAST3

RIPK1

BRK (PTK6)

FAK (PTK2)

MAST4

RIPK2

BRSK1

FER

MELK

RON

BRSK2

FES

MER (MERTK)

RSK1

BTK

FGFR1

MET

RSK2

CaMK1α (CAMK1)

FGFR2

MLK1 (MAP3K9)

RSK3

CaMK2α (CAMK2A)

FGFR3

MLK2 (MAP3K10)

RSK4

CaMK2δ (CAMK2D)

FGFR4

MLK3 (MAP3K11)

SBK3

CDC2 (CDK1)／CycB1

FLT3

MLK4 (MAP3K21)

SGK (SGK1)

CDK2／CycE1

FYN [isoform a] (FYN)

MNK2 (MKNK2)SIK (SIK1)

CDK3／CycE1

GAK

MPSK1 (STK16)

SIK3 (QSK)CDK4／CycD3

HH498 (TNNI3K)

MSK2 (RPS6KA4)

skMLCK (MYLK2)

CDK5／p25 (CDK5R1)

HIPK2

MST1 (STK4)SLK

CDK6／CycD1

HIPK3

MST2 (STK3)

SNRK

CDK7

HIPK4

MUSK

SRM (SRMS)

CDK9／CycK

HPK1 (MAP4K1)

MYLK3

STK32B

CDK10／CycL2

ICK

MYLK4

STK33

CDK14／CycY

IGF1R

MYT1 (PKMYT1)

STK35

CDK15／CycY

IKKε (IKBKE)

NDR1 (STK38)

STK36

CDK17／CycY

INSR

NDR2 (STK38L)

TBK1

CDK18／CycY

IRAK3

NEK1

TEC

CDK20／CycH

IRAK4

NEK2

TIE1

CDKL1

ITK

NEK3

TIE2 (TEK)CDKL2

JAK2[V617F]

NEK4

TLK1

CDKL3

JAK3

NEK5

TLK2

CDKL5

JNK1

NEK9

TNK1

CHK2 (CHEK2)

JNK2

NEK11

TRKA (NTRK1)CK1γ2 (CSNK1G2)

JNK3

NIM1K (MGC42105)

TRKB (NTRK2)

CK1δ (CSNK1D)

LATS1

NLK

TXK

CK2α1 (CSNK2A1)

LATS2

NUAK1

TYRO3

CK2α2 (CSNK2A2)

LCK

p38α (MAPK14)

ULK1

CLK1

LIMK1

p38β (MAPK11)

ULK2

CLK2

LIMK2

PAK4

ULK3

CLK4

LKB1 (STK11)

PAK6

WEE1

CSNK1A1L

LOK (STK10)PCTAIRE1 (CDK16)／CycY

WEE2

DAPK2

LRRK2

PHKG1

ZAK (MLTK)※商品詳細は別紙PRODUCT AND SERVICES 10ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 18

ヒト腫瘍細胞株パネル 対象ヒト腫瘍細胞株リスト

Oncolines™
Cell Line Name
5637
769-P
786-O
A-172
A-204
A375
A388
A-427
A-498
A-549
A-704
ACHN
AN3 CAAsPC-1
AU-565
BT-20
BT-549BxPC-3C-33 ACAL 27
CCF-STTG1
CCRF-CEM
COLO 205
COLO 829
Daoy
DB
DLD-1
DoTc2 4510
DU 145
DU4475
ES-2
FaDu
G-361
HCT 116
HCT-15
HL-60
Hs 578T
Hs 746T
Hs 766THT
HT-1080
HuTu 80
J82
JAR
Jurkat E6.1
K-562
KATO III
KG-1
KLE
KU812
LNCaP FGC

Tissue Origin
Bladder
KidneyKidneyCNSSoft tissue
Skin
Skin
Lung
KidneyLung
KidneyKidneyUterus; endometrium
Pancreas
BreastBreastBreastPancreas
CervixAero-digestive tract
CNS
Blood
Colon
Skin
CNS
Blood
Colon
Cervix
Prostate
BreastOvary
Aero-digestive tract
Skin
Colon
Colon
Blood
BreastStomachPancreas
Blood
Connective tissue
Duodenum
Bladder
Placenta
Blood
Blood
StomachBlood
Uterus; endometrium
Blood
Prostate

Cell Line Name
LoVo
LS 174T
LS411N
MCF7
MeWo
MG-63
MIA PaCa-2
MOLT-4NCCIT
NCI-H460
NCI-H661
NCI-H82
OVCAR-3
PA-1
PC-3
PFSK-1RD
RKO
RL
RL95-2
RPMI-7951
RS4-11
RT4
SHP-77SJCRH30
SK-N-AS
SK-N-FI
SNU-5
SNU-C2BSR
SU-DHL-1
SU-DHL-6
SUP-T1
SW48
SW480
SW620
SW626
SW837
SW872
SW900
SW948
SW982
T24
T98G
TCCSUP
THP-1
TT
U-118 MG
U-2 OS
U-87 MG
VA-ES-BJ

Tissue Origin
Colon
Colon
Cecum
BreastSkin
Bone
Pancreas
Blood
Testis
Lung
Lung
Lung
Ovary
Ovary
Prostate
CNS
Soft tissue
Colon
Blood
Uterus; endometrium
Skin
Blood
Bladder
Lung
Soft tissue
CNS
CNS
Stomach
Cecum
Blood
Blood
Blood
Blood
Colon
Colon
Colon
Colon
RectumSoft tissue
Lung
Colon
Soft tissue
Bladder
CNS
BladderBlood
Thyroid
CNS
Bone
CNS
Soft tissue※商品詳細は別紙PRODUCT AND SERVICES 11ページをご参照ください。
お知らせ： 掲載の内容は予告なく変更する場合があります。予めご了承下さい。

Page 19

タンパク質相互作用のセルベースアッセイ 安定発現細胞株リスト
GPCR

マークの付いた細胞株は弊社ホームページにてリアルタイムモニタリングの動画がご覧いただけます。

Target GPCR and Description

Receptor
FamilyCoupling

Accession
Numberβ-Arrestin
Isoform

Cell LineSpecies

PXC-001-1

ADCYAP1R1

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

VIP and PACAP

Gs

NM_001118

β- Arrestin-1

HEK293Human

PXC-002-2

ADRA2A

Alpha-2-adrenergic receptor

Adrenoceptor

Gi

NM_000681

β- Arrestin-2

HEK293Human

PXC-003-1

ADRB2

Beta-2-adrenergic receptor

Adrenoceptor

Gs

NM_000024

β- Arrestin-1

HEK293Human

PXC-003-2

ADRB2

Beta-2-adrenergic receptor

Adrenoceptor

Gs

NM_000024

β- Arrestin-2

HEK293Human

PXC-004-1

AGTR1

Angiotensin II receptor, type 1

Angiotensin

Gq

NM_000685

β- Arrestin-1

HEK293Human

PXC-004-2

AGTR1

Angiotensin II receptor, type 1

Angiotensin

Gq

NM_000685

β- Arrestin-2

HEK293Human

PXC-005-1

AGTRL1

Apelin receptor

ApelinGi

NM_005161

β- Arrestin-1

HEK293Human

PXC-005-2

AGTRL1

Apelin receptor

ApelinGi

NM_005161

β- Arrestin-2

HEK293Human

PXC-006-1

CCKBR

Cholecystokinin B receptor

Cholecystokinin

Gq

NM_176875

β- Arrestin-1

HEK293Human

PXC-006-2

CCKBR

Cholecystokinin B receptor

Cholecystokinin

Gq

NM_176875

β- Arrestin-2

HEK293Human

PXC-007-1

CCR7

CC chemokine receptor 7 (human)

Chemokine

Gi

NM_001838

β- Arrestin-1

HEK293Human

PXC-007-2

CCR7

CC chemokine receptor 7 (human)

Chemokine

Gi

NM_001838

β- Arrestin-2

HEK293Human

PXC-008-1

EDG1

Endothelial differentiation protein/sphingosine-1-phosphate receptor 1

Lysophospholipid

Gi

NM_001400

β- Arrestin-1

HEK293Human

PXC-008-2

EDG1

Endothelial differentiation protein/sphingosine-1-phosphate receptor 1

Lysophospholipid

Gi

NM_001400

β- Arrestin-2

HEK293Human

PXC-009-2

ENDRA

Endothelin receptor type A

Endothelin

Gq

NM_001957

β- Arrestin-2

HEK293Human

PXC-010-1

ENDRB

Endothelin receptor type B

Endothelin

Gs

NM_000115

β- Arrestin-1

HEK293Human

PXC-010-2

ENDRB

Endothelin receptor type B

Endothelin

Gs

NM_000115

β- Arrestin-2

HEK293Human

PXC-011-1

EP4

Prostaglandin E2 receptor 4

Prostanoid

Gs

NM_000958

β- Arrestin-1

HEK293Human

PXC-011-2

EP4

Prostaglandin E2 receptor 4

Prostanoid

Gs

NM_000958

β- Arrestin-2

HEK293Human

PXC-012-2

NPY1R

Neuropeptide Y receptor Y1

Neuropeptide Y

Gi

NM_000909

β- Arrestin-2

HEK293Human

PXC-013-1

OPRM1

Opioid receptor, mu 1

OpioidGi

NM_000914

β- Arrestin-1

HEK293Human

PXC-013-2

OPRM1

Opioid receptor, mu 1

OpioidGi

NM_000914

β- Arrestin-2

HEK293Human

PXC-014-1

SSTR2

Somatostatin receptor 2Somatostatin

Gi

NM_001050

β- Arrestin-1

HEK293Human

PXC-014-2

SSTR2

Somatostatin receptor 2Somatostatin

Gi

NM_001050

β- Arrestin-2

HEK293Human

PXC-015-1

EDG3

Endothelial differentiation protein/sphingosine-1-phosphate receptor 3

Lysophospholipid

Gi

NM_005226.2

β-Arrestin-1

HEK293

Human

Accession Number (β)

Cell LineSpeciesCat.#

タンパク相互作用
Cat.#

Accession Number (α)

Target Description

PXC-PPI-1

Hif-1 complex

Hypoxia inducible factor 1 alpha, Hydrocarbon receptor nuclear translocator (ARNT)

NM_001530

NM_001668

HEK293Human

PXC-PPI-2

IkBa/b-TRCP Complex

NFKB inhibitor alpha (NFKBIA), beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript

NM_020529

NM_001256856

HEK293Human

PXC-PPI-3

ARIA/PTEN Complex

endothelial cell-specific molecule-2 (ECSM2), protein tyrosine phosphatase (TEP1)

DQ462572

U96180

HEK293

Human

試薬
Cat.#
PXR-SG001

Name of ProductSplit Glow Cell Assay Reagent

安定発現細胞株ご購入時に添付されます。単品でもご購入いただけます。
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Page 20結晶化構造解析サービスターゲットリスト FastLane™ Structures～Premium～
Kinases
BTK

Tyrosine-protein kinase BTK

CK2Casein kinase II subunit alpha

CLK3

Dual specificity protein kinase CLK3

DAPK3(ZIP,ZIPK)

Death-associated protein kinase 3

DYRK1A

Dual specificity tyrosine-phosphorylation-regulated kinase 1A (a.a. 127-485)

EphA7

Ephrin type-A receptor 7 kinase

MAP2K4(JNKK1, MEK4, MKK4)

Dual specificity mitogen-activated protein kinase kinase 4

LATS2

Large tumor suppressor, homolog 2 (Drosophila)

PIK3C3(Vps34)

Phosphatidylinositol 3-kinase catalytic subunit type 3

PFKFB36-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

PIM1

Pim-1 oncogene

PIP4K2A(PIP5K2A)

Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaPLK4(STK18)

Serine/threonine-protein kinase

RSK1

Ribosomal protein S6 kinase

STK10(LOK)LOK or Serine/threonine-protein kinase 10

STK17A(DRAK1)

DRAK1 or Serine/threonine-protein kinase 17A

STK17B(DRAK2)

DRAK2 or Serine/threonine-protein kinase 17B

Epigenetics
ATAD2A

Bromodomain, ATPase family AAA domain-containing protein 2 (a.a. 981-1108)

ATAD2B

Bromodomain, ATPase family AAA domain-containing protein 2B, (a.a. 952-1086)

JMJD2C(KDM4C)

KDM4C or Lysine-specific demethylase 4C (a.a. 1-347)

SMARCA2B

bromodomain of human BRM

SMARCA4

Bromodomain, Transcription activator BRG1

Proteases
Cathepsin C(DPPI)

DPPI or Dipeptidyl peptidase 1

DPP4

Dipeptidyl peptidase 4

Thrombinhuman alpha thrombin

USP7

Ubiquitin specific peptidase 7

USP8

Ubiquitin carboxyl-terminal hydrolase 8

OthersAldose reductase(AR)AR or Aldose reductase (a.a. 1-316)

BCAT2

Branched-chain-amino-acid aminotransferase, mitochondrial

Beta-lactamase(BlaC)

BlaC or Beta-lactamase (M. tuberculosis)

Bfl-1

Bcl-2-related protein A1

DHODH

Dihydroorotate dehydrogenase (human)

DNA GyraseB

Type II topoisomerase

eIF4E

Eukaryotic translation initiation factor 4E

Gal-3C

Galectin-3 carbohydrate recognition domain

Gal-8N

Galectin-8

GART

Trifunctional purine biosynthetic protein adenosine-3

GMPR2

GMP reductase 2

HSP90

Heat shock protein HSP 90-alphaIL-17A

IInterleukin-17A

LDHA

L-lactate dehydrogenase A chain (rabbit)

PDE4D

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

PTP1B(PTPN1)

PTPN1 or Tyrosine-protein phosphatase non-receptor type 1

ROR-gamma

Nuclear receptor ROR-gamma

S100A4(Mts 1)

Mts1 or Protein S100-A4

S100A9(MRP14)

MRP14 or Protein S100-A9

S100A12

Protein S100-A12

TubulinPig tubulin alpha-1A

mAb targets
CD47

Cluster of Differentiation 47

CD137

Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB

CD142(tissue factor)

Platelet tissue factor, factor III

GPVI

Glycoprotein VI

HER2(ERBB2)

Receptor tyrosine-protein kinase erbB-2

IL-23

Interleukin-23

TIM-3

Hepatitis A virus cellular receptor 2

TNF-alphaTumor necrosis factor alfa
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Page 21結晶化構造解析サービスターゲットリスト FastLane™ Structures～FastLane™ Standard～
Kinase
AK1
AK2
AK3L1
AK5
BMPR2
CAMK1D(CaMK1δ)CAMK1G(CaMK1γ)
CAMK2A(CaMK2α)CAMK2B(CaMK2β)
CAMK2D(CaMK2δ)CAMK2G(CaMK2γ)
CAMK4
CLK1
CLK2
CLK3
CSNK1G1(CK1γ1)
CSNK1G2(CK1γ2)
CSNK1G3(CK1γ3)DMPK
DYRK1A
DYRK2
EphA7
FLT1(VEGFR1)
GAK
Haspin(GSG2)
ITPK1
ITPKC
LOK
MAP2K6(MAPKK6, MEK6)
MAP3K5(ASK1, MEKK5)
MAPK11(p38β)
MAPK6(ERK3)
MPSK1(STK16)
MST4
NEK2(NEK2A, NLK1)
PAK4
PAK5(PAK7)
PAK6
PCTK1(PCTAIRE1(CDK16)／CycY)
PHKG2
PIP5K2C(PIP4K2C)
PKM2
PKMYT1PTK2B(PYK2)
RSK1(RPS6KA1 or p90RSK)
SLK
SRPK2
TTK
VRK1
VRK2
VRK3
YSK1(STK25)

Adenylate kinase isoenzyme 1 (a.a. 1-193)
Adenylate kinase isoenzyme 2, mitochondrial (a.a. 1-239)
Adenylate kinase isoenzyme 4, mitochondrial (a.a. 1-223)
Adenylate kinase isoenzyme 5 (a.a. 366-562)
Bone morphogenetic protein receptor type-2 (a.a. 189-517)
Calcium/calmodulin-dependent protein kinase type 1D (a.a. 1-333)
Calcium/calmodulin-dependent protein kinase type 1G (a.a. 18-316)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (a.a. 13-302)
Calcium/calmodulin-dependent protein kinase type II subunit beta (a.a. 11-303)
Calcium/calmodulin-dependent protein kinase type II subunit delta (a.a. 11-309)
Calcium/calmodulin-dependent protein kinase type II subunit gamma (a.a. 5-315)
Calcium/calmodulin-dependent protein kinase type IV (a.a. 15-340)
Dual specificity protein kinase CLK1 (a.a. 148-484)
Dual specificity protein kinase CLK2 (a.a. 135-496)
Dual specificity protein kinase CLK3 (a.a. 284-638)
Casein kinase I isoform gamma-1 (a.a. 45-352)
Casein kinase I isoform gamma-2 (a.a. 43-353)
Casein kinase I isoform gamma-3 (a.a. 35-362)
Myotonin-protein kinase (a.a. 11-420)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (a.a. 127-485)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (a.a. 146-552)
Ephrin type-A receptor 7 (a.a. 590-899)
VEGFR1 or Tyrosine-protein kinase receptor FLT (a.a. 801-1158)
Cyclin-G-associated kinase (a.a. 12-347)
GSG2 or Serine/threonine-protein kinase haspin (a.a. 465-798)
Inositol-tetrakisphosphate 1-kinase (a.a. 1-327)
Inositol-trisphosphate 3-kinase C (a.a. 425-683)
STK10 or Serine/threonine-protein kinase 10 (a.a. 18-317).
Dual specificity mitogen-activated protein kinase kinase 6 (a.a. 47-334)
Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5), (a.a. 659-951)
Mitogen-activated protein kinase 11 (p38b), (a.a. 5-350)
Mitogen-activated protein kinase 6 (a.a. 9-327)
STK16 or Serine/threonine-protein kinase 16 (a.a. 13-305)
Serine/threonine-protein kinase (a.a. 1-300)
Serine/threonine-protein kinase (a.a. 1-271)
Serine/threonine-protein kinase PAK 4 (a.a. 291-591)
PAK7 or Serine/threonine-protein kinase PAK 7 (a.a. 425-719)
Serine/threonine-protein kinase PAK 6 (a.a. 383-681)
Cyclin-dependent kinase 16 (a.a. 163-478)
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (a.a. 6-293)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (a.a. 32-421)
Pyruvate kinase isozymes (a.a. 3-530)
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (a.a. 75-362)
Protein-tyrosine kinase 2-beta (a.a. 414-692)
RPS6KA1 or p90RSK or Ribosomal protein S6 kinase alpha-1 (a.a. 413-719)
STE20-like serine/threonine-protein kinase (a.a. 19-320)
SRSF protein kinase 2 (a.a. 51-688)
Dual specificity protein kinase TTK (a.a. 519-808)
Serine/threonine-protein kinase (a.a. 3-364)
Serine/threonine-protein kinase (a.a. 14-335)
Inactive serine/threonine-protein kinase VRK3 (a.a. 146-474)
STK25 or Serine/threonine kinase 25 (a.a. 1-293)

Phosphatase
DUSP13
IMPA2
INPP5B
INPP5EINPPL1
ITPA
LHPP
MDP1
MTMR6
NANP
PHPT1
PTPN3
PTPN4
PTPN5
PTPN7
PTPN9(MEG2)
PTPN11
PTPN14
PTPN18
PTPN22
PTPRB
PTPRE
PTPRG
PTPRJ
PTPRK
PTPRN2
PTPRO
PTPRR
PTPRT
RNGTT
THTPA

Dual specificity protein phosphatase 13 isoform B (a.a. 1-198)
Inositol monophosphatase 2 (a.a. 16-288)
Type II inositol 1,4,5-trisphosphate 5-phosphatase (a.a. 339-643)
72 kDa inositol polyphosphate 5-phosphatase (a.a. 275-623)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (a.a. 419-732)
Inosine triphosphate pyrophosphatase (a.a. 1-194)
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (a.a. 1-270)
Magnesium-dependent phosphatase 1 (a.a. 1-165)
Myotubularin-related protein 6 (a.a. 1-505)
N-acylneuraminate-9-phosphatase (a.a. 1-248)
14 kDa phosphohistidine phosphatase (a.a. 5-125)
Non-receptor tyrosine-protein phosphatase type 3 (a.a. 628-913)
Non-receptor tyrosine-protein phosphatase type 4 (a.a. 611-926).
Non-receptor tyrosine-protein phosphatase type 5 (a.a. 282-563)
Non-receptor tyrosine-protein phosphatase type 7 (a.a. 65-358)(MEG2), Non-receptor tyrosine-protein phosphatase type 9 (a.a. 277-582)
Non-receptor tyrosine-protein phosphatase type 11 (a.a. 237-533)
Non-receptor tyrosine-protein phosphatase type 14 (a.a. 886-1187)
Non-receptor tyrosine-protein phosphatase type 18 (a.a. 6-299)
Non-receptor tyrosine-protein phosphatase type 22 (a.a. 1-302)
Receptor-type tyrosine-protein phosphatase beta (a.a. 1686-1971)
Receptor-type tyrosine-protein phosphatase epsilon (a.a. 107-697)
Receptor-type tyrosine-protein phosphatase epsilon (a.a. 827-1445)
Receptor-type tyrosine-protein phosphatase eta (a.a. 1019-1311)
Receptor-type tyrosine-protein phosphatase eta (a.a. 865-1154)
Receptor-type tyrosine-protein phosphatase N2 (a.a. 715-1010).
Receptor-type tyrosine-protein phosphatase O (a.a. 916-1208)
Receptor-type tyrosine-protein phosphatase R (a.a. 375-655).
Receptor-type tyrosine-protein phosphatase T (a.a. 868-1151)
mRNA-capping enzyme (a.a. 1-219)
Thiamine-triphosphatase (a.a. 1-215)※商品詳細は別紙PRODUCT AND SERVICES 15ページをご参照ください。
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Page 22結晶化構造解析サービスターゲットリスト FastLane™ Structures～FastLane™ Standard～
Epigenetic : bromodomains
ASH1L
BAZ2B
BPTF
BRD1
BRD9
BRWD1
CECR2
CREBBP
EP300
KAT2A
KAT2B
PBRM1
PBRM1
PBRM1
PBRM1
PBRM1
SMARCA4
PHIP
TAF1
TAF1
TAF1L

Bromodomain, Histone-lysine N-methyltransferase ASH1L (a.a. 2438-2561)
Bromodomain adjacent to zinc finger domain protein 2B (a.a. 2054-2168)
Bromodomain, Nucleosome-remodeling factor subunit BPTF (a.a. 2914-3037)
Bromodomain-containing protein 1 (a.a. 556-688)
Bromodomain-containing protein 9 (a.a. 134-239)
Bromodomain and WD repeat-containing protein 1 (a.a. 1310-1430 Bromodomain 2)
Bromodomain, Cat eye syndrome critical region protein 2 (a.a. 424-538)
Bromodomain, CREB-binding protein (a.a. 1081-1197)
Bromodomain, Histone acetyltransferase p300, (a.a. 1040-1161)
Bromodomain, Histone acetyltransferase KAT2A, (a.a. 729-837).
Bromodomain, Histone acetyltransferase KAT2B (a.a. 715-831)
Bromodomain, Protein polybromo-1 (a.a. 43-156).
Bromodomain, Protein polybromo-1 (a.a. 178-291).
Bromodomain, Protein polybromo-1 (a.a. 388-494)
Bromodomain, Protein polybromo-1 (a.a. 645-766)
Bromodomain, Protein polybromo-1 (a.a. 773-917)
Bromodomain, Transcription activator BRG1 (a.a. 1448-1569).
Bromodomain, PH-interacting protein (a.a. 1302-1434 Bromodomain 2)
Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1373-1635, Bromodomains 1 & 2).
Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1501-1635 Bromodomain 2)
Bromodomain, Transcription initiation factor TFIID subunit 1-like (a.a. 1523-1654)

Epigenetic Demethlases & Others
JMJD2A(KDM4A)
JMJD2B(KDM4B)
JMJD2C(KDM4C)
JMJD2D(KDM4D)
JMJD3(KDM6B)
JMJD6KDM4E(KDM4DL)
MINA
PHF8
PARP2
PARP3
PARP10
PARP12
PARP14
PARP15TNKS
TNKS2ZC3HAV1

JMJD2A - Lysine-specific demethylase 4A (a.a. 1-359).
JMJD2B - KDM4B or Lysine-specific demethylase 4B (a.a. 1-346).
JMJD2C - KDM4C or Lysine-specific demethylase 4C (a.a. 875-995 tudor domains).
JMJD2D - KDM4D or Lysine-specific demethylase 4C (a.a. 12-341).
JMJD3 - Lysine-specific demethylase 6B (a.a.1176-1502).
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (a.a. 1-335)
KDM4DL or Lysine-specific demethylase 4E (a.a. 1-336)
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (a.a. 26-465)
Histone lysine demethylase PHF8 (a.a. 115-483)
Poly [ADP-ribose] polymerase 2 (a.a. 235-579).
Poly [ADP-ribose] polymerase 3 (a.a. 178-532)
Poly [ADP-ribose] polymerase 10 (a.a. 809-1017)
Poly [ADP-ribose] polymerase 12 (a.a. 489-684)
Poly [ADP-ribose] polymerase 14 (a.a. 1611-1801)
Poly [ADP-ribose] polymerase 15 (a.a. 459-656)
Tankyrase-1 (a.a. 1091-1325)
Tankyrase-2 (a.a. 946-1152)
Zinc finger CCCH-type antiviral protein 1 (a.a. 724-896)

Other Targets
ARNT
BAK1
BCL2A1
DPP4
EPAS1(Hif2a)
GLS
GMPR2
MMP12
MTH1(NUDT1 or 7)
NT5C2
NT5C3
NUDT3
NUDT6
NUDT10
NUDT14
NUDT16
NUDT16L1
NUDT18
NUDT21
PHGDH
PSAT1
PPARG
PYCR1
ROR-gamma
THEM2
USP2
USP5

Aryl hydrocarbon receptor nuclear translocator (a.a. 356-470)
Bcl-2 homologous antagonist/killer, mitochondrial apoptosis regulator (a.a. 21-190)
Bcl-2-related protein A1 (a.a. 1-149)
Dipeptidyl peptidase 4
Hif2a or Endothelial PAS domain-containing protein 1 (a.a. 239-350)
Glutaminase kidney isoform, mitochondrial (a.a. 221-533)
GMP reductase 2 (a.a. 10-341).
Matrix metalloproteinase-12
NUDT1 or 7,8-dihydro-8-oxoguanine triphosphatase (a.a. 42-197).
Cytosolic purine 5'-nucleotidase (a.a. 1-536)
Cytosolic 5'-nucleotidase 3A (a.a. 64-336)
Diphosphoinositol polyphosphate phosphohydrolase 1 (a.a. 1-172)
Nucleoside diphosphate-linked moiety X motif 6 (a.a. 141-316)
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (a.a. 17-144)
Uridine diphosphate glucose pyrophosphatase (a.a. 28-222)
U8 snoRNA-decapping enzyme (a.a. aa1-aa195)
Protein syndesmos (a.a. 6-211)8-oxo-dGDP phosphatase NUDT18 (a.a. 26-179)
Cleavage and polyadenylation specificity factor subunit 5 (a.a. 21-227)
D-3-phosphoglycerate dehydrogenase (a.a. 4-314)
Phosphoserine aminotransferase (a.a. 17-370)
Peroxisome proliferator-activated receptor gamma (a.a. 232-505)
Pyrroline-5-carboxylate reductase 1, mitochondrial (a.a. 1-300)
Nuclear receptor ROR-gamma.
Acyl-coenzyme A thioesterase 13 (a.a. 19-140)
Ubiquitin carboxyl-terminal hydrolase 2 (a.a. 258-605)
Ubiquitin carboxyl-terminal hydrolase 5 (a.a. 163-291)※商品詳細は別紙PRODUCT AND SERVICES 15ページをご参照ください。
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Page 23

Memo

Memo