AMMRA
Annual Report
2012Table of Contents

AMMRA, the Past and Future............................................................... 1
Welcome Address ................................................................................ 4
AMMRA Members ............................................................................... 6
AMMRA Charter .................................................................................. 7
AMMRA Organizations........................................................................11
Briefing from Member Institutions......................................................13
Biological Resource Centre, A-STAR, Singapore ...................................15
Center for Animal Resources and Development, Kumamoto ...............17
Laboratory Animal Resource Center, KRIBB, Ochang ...........................23
National Applied Research Laboratories, Taipei ..................................29
National Center for Mutant Mice of China, Nanjing ............................35
RIKEN BioResource Center (BRC), Tsukuba ..........................................43
AMMRA Annual meetings… ............................................................. ..51
Contact List .........................................................................................53

AMMRA, the Past and Future
President – Dr. Xiang Gao
AMMRA services as a strong bondage for us all.
Personally, I wish to express my appreciation to Dr.
Ken-ichi Yamamura for his vision and tremendous
efforts over last 6 years. Of course I am also in debt
to all members in AMMRA for the achievement of
AMMRA. Nothing can be achieved without your hard
work and enthusiasm. And with your continuous
support, AMMRA will overcome all difficulties.

Aiming the functional annotation of all mammal coding genes, several key institutes
for mouse genetic research in EU, American and Canada formed the International
Mouse Knockout Consortium (IKMC) in 2006. Unfortunately, Asian countries were left
out of circle. This fact prompts us to consider establish a multinational organization
for promoting the mouse mutagenesis in Asia. In November 22, 2006, Shanghai
Institute of Life Science of Chinese Academy organized a special workshop forlaunching the Asian Mouse Mutagenesis and Resource Association (AMMRA) at
Shanghai. More than 40 scientists from China, Japan, Korea, Taiwan, and Singapore
attended this meeting and agreed on the needs for establishing AMMRA. AMMRA
mission is “to promote mouse mutagenesis projects and to facilitate access to mouse
resources in Asia”. The founding members include following institutes: 1) Center for
Animal Resources and Development, Kumamoto; 2) Biological Resource Center,
Singapore; 3) National Laboratory Animal Center, National Applied ResearchLaboratories, Taipei; 4) National Resource Center for Mutant Mice, Nanjing University,
Nanjing; 5) Shanghai Institute of Biological Sciences, Shanghai; 6) Shanghai ResearchCenter for Model Organisms, Shanghai; 7) Peking University- BLARC, Beijing, 8)
Beijing Institute of Laboratory Animal Science, CAMS, PUC, Beijing; 9) Bio-Evaluation
1

Center, KRIBB, Daejeon; 10) Riken BioResource Center, Tsukuba. Most of these
institutes are key resource centers in the region. Dr. Kenichi Yamamura from
Kumamoto University, the chairman of the workshop, was elected as first presidentof AMMRA.
Subsequently, AMMRA annual meeting was held at NRCMM at Nanjing in 2007,
KRIBB at Daejeon in 2008, CARD at Kumamoto in 2009, NLAC NARLabs at Taipei in
2010, BRC at Singapore in 2011, and NRCMM at Nanjing in 2012. At early years,
AMMRA activities were mostly focused on the communication among the resource
centers. Eventually, these resource centers started to hold joined the education
program on mouse related technologies. For instance, CARD had held training classes
for cryopreservation in Shanghai and Beijing in 2009 and 2012. The mouse pathology
workshop held by NLAC NARLabs and Johns Hopkins University was opened to all
AMMRA members in 2010. Moreover, MARC of Nanjing University and BRC RIKEN
agreed to establish a joined international short course series for mouse research.
This short course covers broad range of content in mouse genetics, from history ofmouse research to genetic manipulation, disease model phenotyping, stem cell andcloning, cryopreservation, mouse colonial management. The first class was held in
BRC RIKEN in July 2012. And the second class is scheduled in MARC, Nanjing in July
2013.
To further enhance the solid collaboration for generating, preserving and distributing
mouse resources among members, AMMRA outlined the policies and charters of theassociation, such as the definition, mission, goal, purpose, structure, and governanceat the 5th conference in Taipei in November 2010. At the 6th conference organized in
Singapore on November 2011, IT committee (Dr. Masuya at RIKEN BRC serves as thechair) and annual report committee (Dr. Wang from NLAC NARLabs in Taipei serves as
the chair) were formalized. Currently, an integrated database of mouse strains in
Asian is under construction and the first annual report of AMMRA is published in
2013.
The AMMRA activity also facilitated the birth of Asian Mouse Phenotyping
Consortium (AMPC). In September 23rd 2011, the International Mouse Phenotyping
Consortium (IMPC) kicked off at NIH. The ambitious ten years project is aimed tosystematically phenotype KO strains generated using ES cell lines developed by IKMC.
2

Both RIKEN BRC in Japan and MARC in China became the IMPC member in 2011. In
summer of 2012, Korea also joined the IMPC and NLAC in Taiwan will follow soon. In
accordance with the IMPC pipeline, AMMRA members began to discuss additional
functional screening for better utilizing the existing phenotyping platform in China,
Japan, Korea and Taiwan. These discussions eventually led to the inauguration of the
AMPC at Taipei in 2010. All large phenotyping centers, including NLAC NARLabs in
Taiwan, MARC/NRCMM in China, IDB of Fudan University in China, KRIBB in Korea,
and RIKEN BRC in Japan are founding members of AMPC. In March 2012, AMMRA
and AMPC held joined annual meeting in Nanjing, attracted more than 100
participants.
I believe the most important question is whether AMMRA can continuously fulfill its
role in future. With the new genome manipulation technologies, such as ZFN, TALEN
and CRISPR-Cas, mutant mice are generated much easily today. How do we get thesestrains’ information more accurate and faster? Where can we find better service
center for making these disease models? We are still not even close to satisfy
ourselves.
Another crucial issue for AMMRA is that how AMMRA will take concerted action with
the IMPC. The current IMPC pipeline is focused on only gene functional annotation,
not clinic or pharmaceutical applications. For instance, the challenge model or aging
model is not included in the standard IMPC assay. Nevertheless, these assays may
post the most crucial clinic application. Should the AMPC and AMMRA work together
to solve the problem and initiate the new pipeline?
And at last, the training issue. Currently, most the training courses are provided andmanaged by individual institute, is it possible AMMRA serves as a coordinator for
promoting these courses as well as make them more suitable for systematic studies?
Indeed the earth is becoming flat. And we are all become close friends thorough the
AMMRA activities. This annual report just signatures the new beginning of bright
future of Asian mouse research.

3

Welcome Address

Honorary Former Chair – Dr. Ken-ichi Yamamura
Dear AMMRA members,
AMMRA started in 2006. Since then, there weredramatic changes in terms of production,
cryopreservation, supply and phenotyping ofgenetically engineered mice. To promote life sciencesin Asia, it is essential to trust, help, and cooperate witheach other. I believe that initial phase is successful
through the activities of AMMRA. Let’s move on to thegrowth phase of AMMRA.

4

Welcome Address

Vice President – Dr. Yuichi Obata
The mouse is the most sophisticated experimental
animal among many species. By the scientificendeavors over 100 years, many inbred mouse strains
have been established, DNA sequence of a wholegenome was determined and the methods formodification of genes and manipulation of embryo
have been developed. The disadvantage in the mouseas an experimental animal is its high cost of rearing.
Due to this disadvantage, the science using the mouse
was much delayed in Asia when compared with that in North America and Europe.
However, in the last decade or so, significant social and scientific advancement andimprovement were made in Asia. It is time for Asian scientists to be in the front line ofscience. To accelerate this movement in Asia, AMMRA was established.
There are many issues to be solved for AMMRA. Examples are how to ensure easy
access to mouse strains held by AMMRA members, improve technologies, harmonize
quality control of mouse strains, and train and educate of staff in the member
institution. It would be very difficult for a single institution to solve all these issues,
but it may be possible as an association if there are collaborative efforts among
member institutions.
As a vice president of this association, I do my best to help the AMMRA president, Dr.
Gao and each member institutes to accomplish the common goals of AMMRA bysolving issues stated above.

5

AMMRA Members


Biological Resource Center, Singapore (Founding member)Center for Animal Resources and Development, Kumamoto (Founding member)Institute of Developmental Biology and Molecular Medicine of Fudan University,
ShanghaiInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences,
Peking Union Medical College, Beijing (Founding member)Laboratory Animal Resource Center, KRIBB, Ochang (Founding member)Laboratory of Cardiovascular Genomics of Ewha Woman’s University, Seoul
Nanfang Center for Model Organism, Shanghai (Founding member)

National Institute of Food and Drug Safety Evaluation, Seoul

National Laboratory Animal Center, National Applied Research Laboratories,
Taipei (Founding member)

National Resource Center for Mutant Mice, Nanjing University, Nanjing(Founding member)

Peking University-Beijing Laboratory Animal Research Center Mouse Genomics
Center, Beijing (Founding member)

Peking University-Beijing Laboratory Animal Research Center Mouse Genomics
Center, Beijing (Founding member)



Riken BioResource Center, Tsukuba (Founding member)Seoul National University, Seoul

Shanghai Laboratory Animals Center, Shanghai Institute of Biological Sciences,
Shanghai (Founding member)

Sookmyung Women’s University, Seoul

Yonsei University, Seoul
6

AMMRA Charter

Definition
The Asian Mouse Mutagenesis and Resource Association (AMMRA) is a collaborative
group of the development, archiving/distribution, coordination of phenotyping andinformatics of mutant mice in Asia.
MissionTo promote and coordinate the development, archiving/distribution, phenotyping,and informatics of mutant mouse, and to facilitate access to mouse resources in Asia
Goal
Use of mouse models for understanding the genome function and improvement of
human healthPurpose
1. AMMRA is an international organization whose members, in a manner consistent
with the governmental obligations and legal responsibilities of each, pledge to:(1) facilitate the use of mouse resource and research centers across nationalboundaries and barriers in Asia;(2) commit to cooperative, standardized approaches to the development,archiving/distribution and quality control of mouse models;(3) establish commonly shared principles on operation control as regards toanimal health, genetics and environmental management;(4) work cooperatively to facilitate access to and utilization of available resources,
services, and expertise in all aspects of the development,archiving/distribution, coordination of phenotyping and informatics of mousemodels2. AMMRA’s goal is to facilitate the use of mouse models of human disease, behavior
and development for the benefit of researchers in biomedical field.
Structure and Governance
1. The primary criterion for admission to AMMRA institutional membership is each7

member must be a mouse repository or mouse research facilities, supported by
the national government, which has an independent, sustainable operating
budget, and dedicated infrastructure and resources. The applicant organizationmust also agree to the AMMRA’s principles of operations, and actively participate
in AMMRA operations. Commercial membership is also available based on the
merits of the applicant company in compliance to the AMMRA’s principles andwith support to AMMRA activities.
2. AMMRA is governed by the members of Board of Directors (BOD) includingpresident and vice president, comprised of the institutional members of each
Asian country / region.
3. The Board of Directors is responsible for developing strategic and financial plansand, when appropriate, will appoint committees to address specific goals. It is
responsible for:(1) convening at least one meeting annually(2) electing officers(3) considering additions and eliminations of the membership(4) ensuring to maintain the web site(5) empowering educational activities(6) adopting the standards of operation agreed upon in committee(7) preparing amendments to the AMMRA Charter(8) fund raising with governmental, industrial and private funding agencies andacademic institutions(9) overseeing the ultimate dissolution of AMMRA
4. President of AMMRA is elected by the members of Board of Directors (BOD). The
term of President is 2 years and takes turns to be selected from different area.
5. The Vice-President is nominated by the president. The President andVice-President are responsible for the activities and finances of AMMRA, with theconcurrence of the BOD.
6. Prospective member organizations must make application through the BOD of therelevant area. The Vice-President will assist in preparing the case for admission,bring it to the convened AMMRA Board, and shepherd it through to a vote.
Elimination of a member organization will proceed in a similar fashion with the
BOD of the relevant area moving for elimination.
7. Although consensus on all matters will be sought, practice dictates passage of all
votes by a half majority, provided a quorum is present.
8

Head office
President’s institution
Websitehttp://www.ammra.info/
Membership
1. Institutional membership:
Annual fee: $1,000 USD
Duty:(1) Providing information on their resources(2) Sharing mice resources(3) Support to expanding professional techniques in mouse biology(4) Providing annual report according to AMMRA forms
2. Individual membershipOpen to mouse scientists in Asia
Integration of AMMRA into IKMCAMMRA as a whole is integrated into IKMC
Terms of Reference
The role of the Steering Committee is to provide oversight of and to facilitate
coordination between international efforts in the generation of knockout mouse
resources. Specifically the Steering Committee will:
1. Promote coordination of the international efforts through the sharing ofproduction plans (such as gene lists, plans for mouse production, etc.) andproduction status to minimize unnecessary redundancy;
2. Promote maximum efficiency in the generation of mouse-gene knockouts byensuring the sharing of information regarding new approaches and technologies
developed during the programs;
3. Ensure free and open release of data and resources generated;
4. Promote dissemination of knowledge, tools, policy and best practice in the field ofmouse genomics;
5. Promote coordination on issues such as archiving and distribution to ensure thedata and resources generated are readily accessible to the scientific community;
6. Promote discussion of future strategy for mouse functional genomics;
9

7. Coordinate public communications regarding individual efforts or the international
effort as a whole.
Advisory Board
Advisory Board members will be invited from global society in the field of mouse
genetics and other related field.

10

AMMRA Organizations

President(Term 2012-2014)

Xiang Gao, NRCMM

Vice-President(Term 2012-2014)

Yuichi Obata, Riken BRC

BOD from Institutional Members

Kumamoto University
Riken BRC
Nanjing University
KRIBB
BRC
NLAC NARLabs

General Secretary and Treasurer

Je Kyung Seong, SNU

IT Committee

Hiroshi Masuya, Riken BRC (Chair)
Arun Kumar Manickam, BRC
Ki-Hoan Nam, KRIBB
Xiaojun Lei, NRCMM
Hsian-Jean Genie Chin, NLAC NARLabs
Yukiko Yamazaki, NIG

Annual Report Committee

Chi-Kuang Leo Wang, NLAC NARLabs (Chair)

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12

Briefing from Member Institutions

13

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Biological Resource Centre, A-STAR, Singapore
Institute Director/ President

Dr. Lim Juay Yong

AMMRA contact person 1

Dr. Sathivel Ponniah

Phone(65)6478 8568

E-mailPonniah_sathivel@brc.a-star.edu.sg

AMMRA contact person 2

Manickam Arun Kumar

Phone(65)6478 8575

E-mailarunkumar@brc.a-star.edu.sg

Mailing address

Biological Resource Centre,
20 Biopolis Way #07-01 Centros,
Singapore 138668

Institute address

Biological Resource Centre,
20 Biopolis Way #07-01 Centros,
Singapore 138668

Websitewww.brc.a-star.edu.sg

15

Biological Resource Centre, A-STAR, Singapore
Institution Briefing
Biological Resource Centre (BRC) started its operation in 2005. It was set up to serve
the laboratories of the A-STAR institutes to meet their research-related animal
requirements.
BRC houses mice, rats, guinea pigs, rabbits and mini pigs. One of its main functions
include basic husbandry of these animals and providing an optimal environment suchthat the external factors influencing the researchers’ work is minimized.
BRC offers scientific services and these include microinjection of DNA and ES cells in
mice, cryopreservation of mouse spermatozoa and embryos and rederivation of mice
into SPF.
BRC would like to share its available mutant strains with the AMMRA community andis working with the respective researchers to obtain their approval, while at thesame time benefit from the other available strains from the AMMRA members.

16

Center for Animal Resources and Development, Kumamoto
Institute Director/ President

Urano Toru

AMMRA contact person

Ken-ichi Yamamura

Phone+81-96-373-6596

Emailyamamura@gpo.kumamoto-u.ac.jp

Address

2-2-1 Honjo, Kumamoto 860-0811, Japan

Websitehttp://card.medic.kumamoto

17

Center for Animal Resources and Development, Kumamoto

Part I – Institution Briefing










The CARD is located at Honjo campus, Kumamoto University which is one of thegovernment-funded non-profit national university corporation and wasestablished in 1998 according to recommendations published in the report“Preservation, Supply and Development of Genetically Engineered Animals” by
the Ministry of Education, Culture, Sports, Science and Technology in JapanWeb sites (http://card.medic.kumamoto-u.ac.jp/card/english/index.html).
CARD is a world hub center for production, phenotyping, cryopreservation, andsupply of genetically engineered mice. To promote biological sciences
worldwide, CARD produces genetically engineered mice and exchangeable genetrap ES cell clones, cryopreserves mouse embryos and sperm, supplies theseresources and organizes training courses to educate people. Kumamoto Mouse
Clinic will start its full activity on April, 2013.
As a founding member of the International Gene Trap Consortium, theFederation of International Mouse Resources (FIMRe), and the Asian Mouse
Mutagenesis and Resource Association (AMMRA), CARD is contributing to thepromotion of biological sciences in the world. CARD transfers data on mousestrains to the International Mouse Strain Resource (IMSR,
http://www.findmice.org/) and data on Exchangeable Gene Trap Clone(http://egtc.jp/) to the International Gene Trap Consortium (IGTC,
http://www.genetrap.org/index.html).
Information on various services can be obtained at the CARD web site(http://cardb.cc.kumamoto-u.ac.jp/transgenic/index.jsp).
Recently, we developed a high efficient cryopreservation method for mouse spermfrom any strain including C57BL/6. More than 1,000 pups can be obtained using
frozen-thawed sperm from just one C57BL/6 male via in vitro fertilization and18

embryo transfer techniques.
(http://card.medic.kumamoto-u.ac.jp/card/english/sigen/manual/spfreeze.html).

19

Part II - Mouse/Rat Strain Resource
Center for Animal Resources and Development
CARD, Kumamoto University
Repository Director

Ken-ichi Yamamura

Emailyamamura@gpo.kumamoto-u.ac.jp

Repository personnel

PI: 1
Staff: 10

Mouse strain resource

Cryopreserved: 1,532

IMSR registered?

● Yes
○ No

Source of resource○ Government funding generated● Deposited by researchers

Wild type andspontaneous
mutation, 15,
1%
Inducedmutation , 5,0%Targeted
mutation andTransgenic,
668, 45%

Mutant
Mouse
Strains
Gene trap,
818, 54%20

Part III - Special Announcement
We had training courses on Cryopreservation of Mouse Germplasm in othercountries.
1) Shanghai Laboratory Animal Center, Chinese Academy of Sciences, Shanghai(2002)
2) College of Life Sciences, Peking University, Beijing (2005)
3) Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), Chungbuk (2008)
4) BIOPOLIS, Singapore (2011)
5) National Laboratory Animal Center, National Applied Research Laboratories (NLAC
NARLabs), Taipei (2012).

We have been establishing online manuals concerning reproductive engineering
techniques in mice.
http://card.medic.kumamoto-u.ac.jp/card/english/sigen/index.html

21

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Korea Research Institute of Bioscience and Biotechnology, Ochang
Institute Director/ President

Dr. Hyoung-Chin Kim

AMMRA contact person

Dr. Hyoung-Chin Kim

Phone+82-43-240-6560

Emailhckim@kribb.re.kr

Address

Biomedical mouse resource center, KRIBB,
30 Yeongudanji-ro, Ochang-eup, Chengwon-gun,
Chungcheongbuk-do 363-883, Korea

Websitehttp://www.kribb.re.kr/(KRIBB)
http://mouse.kribb.re.kr/(LARC, KRIBB, under reconstruction)

23

Laboratory Animal Resource Center, KRIBB, OchangPart I – Institution Briefing
Korea Research Institute of Bioscience and Biotechnology (KRIBB) is a non-profit
institute funded by Korean government.
The Korea Research Institute of Bioscience and Biotechnology (KRIBB) is thegovernment-funded non-profit research institute dedicated to state-of the-art
bioscience and biotechnology. The Korean government has been systematicallypromoting biotechnology through the national plan [Bio-Vision 2016] to make Korea
much stronger in bioscience and technology.

KRIBB is also designated by Ministry of Education, Science and Technology (MEST) asa principal institution responsible for archiving resources used for researches anddevelopment in the field of bioscience. The Laboratory Animal Resource Center(LARC), KRIBB is one of the centers in KRIBB and is in charge of the archiving mouse
resource.
Therefore, one of the main missions of LARC, KRIBB is to archive the mouse resource.
Deposited mouse resources are kept as frozen embryos or sperms. Those frozen
24resources are re-vitalized when requested by researchers. One of the mostimportant works serviced by LARC, KRIBB is to diagnose microbiologicalcontamination in mouse and to clean them. LARC, KRIBB have a platform to produce
chimeric mouse using ES cell clones, but do not provide a paid service yet. The
information on the deposited mouse strains is accumulated into our data base which
is opened to public in a limited fashion. LARC, KRIBB also is building a broad-based
mouse phenotyping platform right now. LARC, KRIBB will provide these services toscientific society, soon.
LARC, KRIBB is always seeking new ways to provide a better service to researchcommunity.

25

Part II - Mouse/Rat Strain Resource

MBRC
Repository Director

Dr. Hyoung-Chin Kim

Emailhckim@kribb.re.kr

Repository personnel

PI: 4
Staff: 23

Mouse strain Resource

Live: 10
Cryopreserved: 96

IMSR registered?

○ Yes
● No

Source of resource● Government funding generated● Deposited by researchers

Wild type andspontaneous
mutation, 2,2%Inducedmutation , 23,
22%

Mutant
Mouse
Strains
Targeted
mutation andTransgenic,
78, 73%

Gene trap, 3,
3%

26

Part III - Special Announcement
Local training
Laboratory animal Workshop- Basic technics for laboratory animals- Health and genetic monitoring- Embryo freezing/thawing/transfer
Date: November 20-21, 2012
Place: KRIBB
Organizer: KRIBBCIEA-KRIBB Joint
Workshop- Health monitoring& management
Date: March 14-16, 2013
Place: KRIBB
Organizer: KRIBB-CIEA

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National Laboratory Animal Center,
National Applied Research Laboratories, Taipei
Institute Director/ President

Dr. Chun-Keung Yu

AMMRA contact person

Dr. Chi-Kuang Leo Wang

Phone

+886-2-27895567

Emailcklwang@nlac.narl.org.tw

Mailing address

P.O. BOX 1-86 Nangang, Taipei City 11529
TaiwanInstitute address

128 Academia Road, Section 2, Nankang, Taipei
115, Taiwan

Websitehttp://www.nlac.org.tw/english/default.asp

29National Laboratory Animal Center,
National Applied Research Laboratories, Taipei

Part I – Institution Briefing
The National Laboratory Animal Center (NLAC) is a non-profit institute under the
National Applied Research Laboratories (NARLabs); the funding source is supportedby the government. The missions of NLAC NARLabs are to supply rodent resources
and technical supports for the research communities in Taiwan. NLAC NARLabs
operations are accredited by ISO/IEC17025, ISO27001:2005, ISO 9001:2008, andawarded by AAALAC Full Accreditation; NLAC NARLabs services are also enrolled in
Performance Evaluation Program for Diagnostic Laboratories (PEP) to assure quality
control performance.
In addition to the rodent supply and diagnostic services, NLAC NARLabs has been
devoting deeply in the generation, archiving and sharing of GM mouse and rat
models. To advocate the use of important rodent resource in Taiwan, NLAC
NARLabs lunched a regional repository project in 2009, named Rodent Model
Resource Center (RMRC). RMRC-NLAC offers cryopreservation and ART services
upon requests to collect and preserve GM models generated by researchers in
Taiwan. Furthermore, RMRC-NLAC also generates novel GM models to enrich therepository resource. Since 2010, RMRC-NLAC has been a registered member ofInternational Mouse Strain Resource (IMSR). With the successful development of aunique BAC gene manipulation system, NLAC NARLabs subsequently strengthens thetransgenic mice/rat platform as well as the conditional knockout / Cre mice
production pipelines.
To better support the research communities, NLAC NARLabs will continuously seek
for connection and collaboration with renowned organizations and associations
around the world.

30

Part II - Mouse/Rat Strain Resource

Rodent Model Resource Center (RMRC)
Repository Director

Dr. Chi-Kuang Leo Wang

Emailcklwang@nlac.narl.org.tw

Repository personnel

PI: 6
Staff: 43

Mouse strain Resource

Live: 35
Cryopreserved: 97

Rat strain Resource

Live: 9IMSR registered?

● Yes
○ No

Source of resource● Government funding generated● Deposited by researchers

Wild type andspontaneous
mutation, 19,
13%

Mutant
Mouse
Strains

Inducedmutation , 4,3%31Targeted
mutation andTransgenic,
118, 84%

Part III - Special Announcement
Local training
Breeding and analysis Course of the genetic modification Mice
-GEMMS workshop of TG mice
Date: February 13-14, 2012
Place: Academia Sinica
Organizer: NLAC NARLabs-GEMMS
Sponsors: TMMC, TMC
Mouse and Rat Blood Sampling, Drug Administration, Euthanasia Practical Training& Introduction to Histology
February 17, 2012 @ NLAC NARLabs-Taipei CenterApril 03, 2012 @ NLAC NARLabs-Tainan Facility
May 25, 2012 @ NLAC NARLabs-Taipei Center
September 25, 2012 @ NLAC NARLabs-Tainan Facility
Clinical and Pathological Phenotyping Course
April 19, 2012 @ Academia SinicaJune 28, 2012 @ NLAC NARLabs-Tainan Facility

Mouse Colony Management Workshop
Date: August 27, 2012
Place: Academia Sinica
Bone Marrow Smear Examination
Date: October 03, 2012
Place: Academia Sinica
Physiological Features and Common
Diseases of Rodent and Rabbit
Date: November 20, 2012
Place: Academia Sinica
Cryopreservation and Reproduction Techniques for Laboratory Mouse
32

NLAC NARLabs with Center for Animal Resources & Development (CARD) of
Kumamoto University, Japan signed the memorandum of cooperation in 2010, washonored to introduce the course of Dr. Nakagata team this year. The course will
provide 2-Days training program to Reproductive engineering techniques and theirapplication in mice.
Date: November 14-15, 2012
Place: NLAC NARLabs-Taipei Center
Laboratory Rodent Histology
Date: December 11, 2012
Place: Academia Sinica
NLAC NARLabs plans to hold an advanced course related to rodent animal models
with speakers from Jackson Laboratory in 2014.

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National Resource Center of Mutant Mice (NRCMM), Nanjing
Institute Director/ President

Dr. Xiang Gao

AMMRA contact person

Dr. Jing Zhao

Phone

+86 2558641533

Emailzhaojing@nicemice.cn,
gaoxiang@nju.edu.cn

Address

12 Xuefu Road, Pukou District, Nanjing
210061

Websitewww.nicemice.cn
www.nbri-nju.com/en-us/35

National Center for Mutant Mice of China, NanjingPart I – Institution Briefing
National Resource Center of Mutant Mice (NRCMM) is one of the 8 national
laboratory animal resource centers designated by the Ministry of Science andTechnology of China. Established in 2005, NRCMM is affiliated with the Model
Animal Research Center of Nanjing University (MARC) and Nanjing Biomedical
Research Institute of Nanjing University (NBRI).
The mission of NRCMM is to promote the biomedical research in China by providing
services related to mouse models. NRCMM services include depository,
cryopreservation, and distribution of mutant mice. As one of the major transgenic
platforms in China, NRCMM also provide services to generate and phenotype KI/KO
and transgenic mouse lines for biomedical research community. In addition, NRCMM
also hosts education programs for mouse colony management and mouse genetics
studies.
NRCMM has three divisions. The resource department is responsible for the mouse
importation, breeding, distribution, cryopreservation, and genetic/microbiologicalmonitoring. The technical service department provides transgenic service andphenotyping service. And the administration office manages the human resource,
financial affair, facility maintenance, and education program.
NRCMM joined the International Mouse Phenotyping Consortium in 2011 and is thefounding member of Asian Mouse Mutagenesis and Resource Association (AMMRA)
and Asian Mouse Phenotyping Consortium (AMPC). NRCMM became a member ofInternational Mouse Strain Resource (IMSR) since 2011. Currently, NRCMM holds
total 1400 strains of mice. 508 strains are available for general distribution in 2012.
NRCMM has been awarded full accreditation by AAALACI since 2006.
36

In 2012, NRCMM supplied more than 220 strains of mice to more than 300 customs
in China. These customs include 88 universities, 60 research institutes, 97 hospitals,
and 30 pharmaceutical companies in 29 provinces. Most of these mice are used as
disease models for diabetes, AD, autoimmune diseases. NRCMM also helped theChinese scientists in 29 research institutes/universities to import total 73 strains ofmice from US, UK, France, Australia and Austria.
In return, NRCMM is grateful to receive 72 new mutant strains donated by scientists
in China in 2012. Additional information can be found at www.nicemice.cn andwww.nbri-nju.com/en-us/

37

Part II - Mouse/Rat Strain Resource

National Resource Center of Mutant Mice (NRCMM)
Repository Director

Dr. Xiang Gao

Emailgaoxiang@nju.edu.cn

Mouse strain Resource

Live: 245
Cryopreserved: 264

IMSR registered?

● Yes
○ No

Source of resource● Government funding generated● Deposited by researchers

Wild type andspontaneous
mutation, 33,
7%Targeted
mutation andTransgenic,
399, 78%

Mutant
Mouse
Strains

Inducedmutation , 77,15%38

Part III - Special Announcement
7th AMMRA and 3rd AMPC Annual Meeting. Nanjing, China. March 15-17, 2012
Delegations of AMMRA and IMPC joined the meeting and reported the activity ofeach centers around Asian. Dr. Xiang Gao became the president of AMMRA and Dr.
Yuichi Obata was voted as President-elected for next term.
Onsite visit from AAALACI. Nanjing, China. July 21-23, 2012
This was the third onsite evaluation by AAALACI. NRCMM became the first institutethat fully complying with the new NIH Guide for Laboratory Animal Use and Care in
China. A full accreditation was awarded again by AAALACI in December.
4th Summer Camp for Model Animal Research. Nanjing, China. July 15-24, 2012
More than 60 senior college students participated in this summer camp.
Nanjing University MARC/RIKEN BRC International Short Summer Course of the
Mouse. Tsukuba, Japan. August 27-29, 2012
The course provided comprehensive introduction for model technology of mouse
genetics and phenotyping. 16 students from 5 countries joined the course.
Model Animal Research Workshop for Celebrating 10 Year Anniversary of MARC.
Nanjing, China. November 9-19, 2012
More than 100 top scientists form US, UK, Japan, and China joined the celebration
and workshop.
Selected Publications from NRCMM
1. Jiang X, Zhou Y, Xian L, Chen WQ, Wu HW, Gao X (2012) The mutation in Chd7
causes misexpression of Bmp4 and developmental defects in telencephalicmidline. American Journal of Pathology 181: 626-641.
2. Zhou Y, Jiang X, Gu PY, Chen WQ, Zeng XS, Gao X (2012) Gsdma3 mutation causes
bulge stem cell depletion and alopecia mediated by skin inflammation. American
Journal of Pathology 180: 763-774.
3. Ducommun S, Wang HY, Sakamoto K, MacKintosh C, Chen S (2012)
Thr(649)Ala-AS160 knock-in mutation does not impair
contraction/AICAR-induced glucose transport in mouse muscle. American Journalof Physiology-Endocrinology and Metabolism 302: E1036-E1043.
4. Yang H, Shi LY, Wang BA, Liang D, Zhong CQ, Liu W, Nie YZ, Liu J, Zhao J, Gao X, Li
39

DS, Xu GL, Li JS (2012) Generation of genetically modiﬁed mice by oocyte
injection of androgenetic haploid embryonic stem cells. Cell, 149:605-17
5. Lin ZY, Perez P, Lei D, Xua J, Gao X, Bao JX (2011) Two-phase analysis of molecularpathways underlying iPS cell induction. Stem Cells, 29:1963-74
6. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X (2012) Fibroblast
growth factor 13 is a microtubule-stabilizing protein regulating neuronalpolarization and migration. Cell. 149:1549-64.
7. Yang WW, Xia Y, Ji HT, Zheng YH, Liang J, Huang WH, Gao X, Aldape K, Lu ZM (2011)
Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.
Nature, 478: 118-122
8. Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD,
Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y (2011) PKA phosphorylation couples
hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism.
Proc Natl Acad Sci USA. 108:15852-7
9. Di RM, Wu XQ, Chang Z, Zhao X, Feng QT, Lu SS, Luan Q, Hemmings BA, Li XL,Yang ZZ (2012) S6K inhibition renders cardiac protection against myocardial
infarction through PDK1 phosphorylation of Akt. Biochemical Journal 441:
199-207.
10. Sun T, Zheng W, Peng H, Zhang A, Chen Y, Tan R, Shen P (2012) A small molecule
IFB07188 inhibits proliferation of human cancer cells by inducing G2/M cell cycle
arrest and apoptosis. Biomed Pharmacother 66: 512-518.
11. Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, Wu X, Dong Z, Gao X, Liu G, Yang L, Xu Y
(2012) The circadian mutation PER2(S662G) is linked to cell cycle progression andtumorigenesis. Cell Death and Differentiation 19: 397-405.
12. Chu DD, Pan HS, Wan P, Wu J, Luo J, Zhu H, Chen J (2012) AIP1 acts with cofilin tocontrol actin dynamics during epithelial morphogenesis. Development 139:
3561-3571.
13. Shi DQ, Dai J, Ikegawa S, Jiang Q (2012) Genetic study on developmental dysplasiaof the hip. European Journal of Clinical Investigation 42: 1121-1125.
14. Wang L, Chen X, Zheng YY, Li F, Lu Z, Chen C, Liu J, Wang Y, Peng YJ, Shen ZL, Gao
JM, Zhu MS, Chen HQ (2012) MiR-23a inhibits myogenic differentiation throughdown regulation of fast myosin heavy chain isoforms. Experimental Cell Research
318: 2324-2334.
15. Yu Y, Lv N, Lu Z, Zheng YY, Zhang WC, Chen C, Peng YJ, He WQ, Meng FQ, Zhu MS,
Chen HQ (2012) Deletion of myosin light chain kinase in endothelial cells has aminor effect on the lipopolysaccharide-induced increase in microvascularendothelium permeability in mice. Febs Journal 279: 1485-1494.

40

16. Gu PY, Qi X, Zhou Y, Wang Y, Gao X (2012) Generation of Ppp2Ca and Ppp2Cb
conditional null alleles in mouse. Genesis 50: 429-436.
17. Yang W, Lu Y, Xu Y, Xu L, Zheng W, Wu Y, Li L, Shen P (2012) Estrogen Represses
Hepatocellular Carcinoma (HCC) Growth via Inhibiting Alternative Activation ofTumor-associated Macrophages (TAMs). J Biol Chem 287: 40140-40149.
18. Lu Y, Bao XF, Sun TZ, Xu JF, Zheng W, Shen PP (2012) Triptolide attenuate theoxidative stress induced by LPS/D-GalN in mice. Journal of Cellular Biochemistry113: 1022-1033.
19. Xu HW, Wei YN, Zhang Y, Xu YC, Li F, Liu J, Zhang W, Han XD, Tan RX, Shen PP (2012)
Oestrogen attenuates tumour progression in hepatocellular carcinoma. Journal of
Pathology 228: 216-229.
20. Zhang Q, He XY, Chen L, Zhang CX, Gao X, Yang ZZ, Liu G (2012) Synergistic
regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion
morphogenesis during heart development. Journal of Pathology 228: 416-428.
21. Zhang CH, Chen C, Lifshitz LM, Fogarty KE, Zhu MS, ZhuGe RH (2012) Activation of
BK channels may not be required for bitter tastant-induced bronchodilation.
Nature Medicine 18: 648-650.
22. Xu JY, Qi X, Gong JF, Yu MY, Zhang FX, Sha HB, Gao X (2012) Fstl1 Antagonizes BMP
Signaling and Regulates Ureter Development. Plos One 7: e32554.
23. Zhu GJ, Wang F, Chen C, Xu L, Zhang WC, Fan C, Peng YJ, Chen J, He WQ, Guo SY,
Zuo J, Gao X, Zhu MS (2012) Myosin Light-Chain Kinase Is Necessary for
Membrane Homeostasis in Cochlear Inner Hair Cells. Plos One 7: e34894.
24. Yan J, Xie BX, Capodice JL, Katz AE (2012) Zyflamend inhibits the expression andfunction of androgen receptor and acts synergistically with bicalutimide to inhibit
prostate cancer cell growth. Prostate 72: 244-252.

41

42

RIKEN BioResource Center (BRC), Tsukuba
Institute Director/ President

Yuichi Obata

AMMRA contact person

Yuichi Obata

Phone+81-29-836-9144

Emailyobata@rtc.riken.go.jp

Address

3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan

Websitehttp://www.brc.riken.jp/inf/en/index.shtml

43

RIKEN BioResource Center (BRC), TsukubaPart I – Institution Briefing

RIKEN BioResource Center (BRC) was established in 2001 at Tsukuba, Japan.
Type and Funding source: Not-for-profit and government-funded institution.

Experimental Animal Division (http://www.brc.riken.jp/lab/animal/en/) has
been designated as the core facility for mouse resources by the National
Bioresource Project (NBRP, http://www.nbrp.jp/index.jsp) of the MEXT, Japan
since FY2002.
A searchable database: http://www2.brc.riken.jp/lab/animal/search.php
A contact address: animal@brc.riken.jp
Cryopreservation and advanced reproductive technology: Bioresource
Engineering Division headed by Dr. Atsuo Ogura.
http://www.brc.riken.jp/lab/kougaku/indexE.html
A phenotyping platform: Japan Mouse Clinic lead by Dr. Shigeharu Wakana.








http://www.brc.riken.jp/lab/jmc/mouse_clinic/en/index.html
RIKEN BRC is a founding member of Asian Mouse Mutagenesis & Resource
Association (AMMRA, http://www.ammra.info/), The Federation ofInternational Mouse Resources (FIMRe, http://www.fimre.org/), Asian Mouse
Phenotyping Consortium (AMPC, http://ampc.asia), and Asian Network of
Research Resource Centers (ANRRC, http://www.anrrc.org/).
44







RIKEN BRC registers its mouse strains in the International Mouse Strain Resource(IMSR, http://www.findmice.org/), a one-stop database of FIMRe, and gene-trap
ES cells in the International Gene Trap Consortium (IGTC,
http://www.genetrap.org/index.html).
Japan Mouse Clinic and Experimental Animal Division have been participating in
the International Mouse Phenotyping Consortium (IMPC) since September,2011. http://www.mousephenotype.org/
RIKEN BRC has been offering training courses on advanced technologies for theuse of mouse resources to Asian scientists and technicians

NANJING UNIVERSITY MARC/RIKEN BRC International Short Summer Course of the Mouse
was held on August 27-29, 2012 at RIKEN BRC, Tsukuba. Fifteen trainees from 6
countries participated in the course.

45

Part II - Mouse/Rat Strain Resource

RIKEN BRC Experimental Animal Division
Repository Director

Atsushi Yoshiki, Ph.D., Head

Emailyoshiki@brc.riken.jp

Repository personnel

PI: 1
Senior Research Scientist: 2
Senior Technical Scientist: 2
Research Scientist: 1
Technical Staff: 11
Contract Staff: 53

Websitehttp://www.brc.riken.jp/lab/animal/en/

Mouse strain Resource

Live: 660
Cryopreserved: 4,120
ES/iPS cells a: 1,769
BAC clones b: C57BL/6N, MSM

Rat strain Resource

BAC clonesb: F344, LE, ACIIMSR registered?

● Yes
○ No

Source of resource● Government funding generated● Deposited by researchers

Notes:
a: 1,750 gene-trap ES cell clones developed by Dr. Ishida, 12 mouse ES cells, and 7
iPS cells are distributed from RIKEN BRC Cell Engineering Division (Cell Bank)(Dr. Yukio Nakamura, cellqa@brc.riken.jp).
b: Distributed from RIKEN BRC Gene Engineering Division (DNA Bank) (Dr. Yuichi
Obata, dnabank@brc.riken.jp).

46Mutant
Mouse
Strains

Transgenic

1,787, 26%

Targeted knockout

1,702, 25%

Gene-trap

242, 4%

ENU-induced phenotype-driven mutant

506, 7%

ENU-induced gene-driven mutant

561, 8%Wild-derived

153, 2%Inbred and spontaneous mutant

81, 1%

Recombinant inbred

62, 1%

Consomic

39, 1%

Gene-trap ES clones (Cell Bank, RIKEN
BRC)
471,750, 25%

Ins1 Pancreatic
beta cells

Vil1 Gut epitheium

Wap Mammary
gland epithelium

Tek/Tie2
Endothelium

Tissue-specific cre mice for conditional experiments

48

Part III - Special Announcement
NANJING UNIVERSITY MARC/RIKEN BRC International Short Summer Course of the
Mouse will be held on August 27-29, 2012.
The First International Short Summer Course of the Mouse by Model Animal
Research Center, Nanjing University, China (Director: Dr. Xiang Gao) and RIKEN
BioResource Center, Japan (Director: Dr. Yuichi Obata) was co-organized by Drs. Xiang
Gao and Yoichi Gondo. The course provided a short educational program using
laboratory mouse and navigate participants from basic to cutting-edge technologies.
A laboratory tour at RIKEN BioResource Center was also included in the program.
IMPC International Symposium in Tokyo -International Mouse Phenotyping
Consortium: -Its activity and value for biomedical sciencesDate: September 28th, 2012 10:00-17:00
Place: WTC Conference Center (Hamamatsu-cho, Tokyo)
Organizer: RIKEN BRC
Sponsors: IMPC, MEXT, JALAS & MBSJURL http://impc.brc.riken.jp/en/sympo_1.html
The 60th annual meeting of Japanese Association of Laboratory Animal Science(JALAS) will be held on May 15-17, 2013 at Tsukuba International Congress Centerby Dr. Yuichi Obata, Director of RIKEN BRC.
2013 AMMRA & AMPC business meeting will be held on May 18th at RIKEN BRC.

RIKEN BRC/NANJING UNIVERSITY MARC International Summer Intensive Course of
the Mouse will be held on July 29-31, 2013 at MARC of Nanjing University.
Keynote speakers: Dr. Tom Weaver, Director of MRC Mary Lyon Centre (UK) andProf. David Wasserman, Director of Mouse Metabolic Phenotyping Center,
Vanderbilt University

49

50

AMMRA annual meetings
1st AMMRA meeting, Shanghai, China, Nov., 22-24, 2006
2nd AMMRA meeting, Nanjing, China, Nov., 14-16, 2007
3rd AMMRA meeting, Daejeon, Korea, Oct., 23-24, 2008
4th AMMRA meeting, Kumamoto, Japan, Dec. 17-18, 2009
5th AMMRA pre-meeting, HongKong, Aug., 26-27, 2010
5th AMMRA meeting, Taipei, Taiwan, Nov., 8-11, 2010
6th AMMRA meeting, Biopolis, Singapore, Nov., 29-Dec., 2, 2011
7th AMMRA meeting, Nanjing, China, Mar., 15-17, 2012
8th AMMRA meeting, Tsukuba, Japan, May, 18, 2013

51

52

(Accumulative list of attendants from past AMMRA meetings)

ARAKI, Kimi
IRDA, Kumamoto University, Japanarakimi@gpo.kumamoto-u.ac.jp
ARAKI, Masatake
IRDA, Kumamoto University, Japan
maraki@gpo.kumamoto-u.ac.jp
CHIN, Hsian-Jean
National Laboratory Animal Center
National Applied Research Laboratories, Taiwan
geneichin@nlac.narl.org.tw
CHUNG, Bon-Chu
Institute of Molecular Biology, Academia Sinica, Taiwan
mbchung@sinica.edu.tw
DENG, Hongkui
Department of Cell Biology
The college of Life Sciences, Peking University, China
hongkui_deng@pku.edu.cn
FEI, Jian
Shanghai Research Center for Biomodel Organism, China
Jfei@sibs.ac.cn
GAN, Ke
Model Animal Research Center, Nanjing University, China
ganke1131105@163.com
GAO, Xiang
Nanjing University; China
gaoxiang@nju.edu.cn
GONDO, Yoichi
RIKEN BioResource Center, Japan
53

CONTACT LIST

Contact List

CONTACT LIST

gondo@brc.riken.jp
IKAWA, Masahito
Research Institute for Microbial Diseases, Osaka University, Japanikawa@biken.osaka-u.ac.jp
IWAKURA, Yoichiro
Center for Experimental Medicine and Systems Biology
Institute of Medical Science, University of Tokyo, Japaniwakura@ims.u-tokyo.ac.jp
HICKS, Geoffrey
University of Manitoba; Canada
hicksgg@cc.umanitoba.ca
JIANG, Si-Tse
National Laboratory Animal Center
National Applied Research Laboratories, Taiwan
stjiang@nlac.narl.org.tw
KAKUTA, Shigeru
Center for Experimental Medicine and Systems Biology
Institute of Medical Science, University of Tokyo, Japan
kakuta@ims.u-tokyo.ac.jp
KANEDA, Hideki
RIKEN BioResource Center, Japanhkaneda@brc.riken.jp
KANG, Hoil
National Institute of Food and Drug Safety Evaluation
Korea Food and Drug Administration, Korea
kanghoil@korea.kr
KATOH, Hideki
Institute for Experimental Animals
Hama-matsu University School of Medicine, Japanhideki-k@hama-med.ac.jp
KIM, Hyoung-Chin
Korea Research Institute of Bioscience and Biotechnology, Korea
hckim@kribb.re.kr
KOROGI, Rie
Institute of Resource Development and Analysis, Kumamoto University, Japan
54

Institute of laboratory Animal Science,
Peking Union Medical College and Chinese Academy of Medical Sciences,
China
Li_Wanbo2006@yahoo.com.cn
LIN, Shu-Wha
College of Medicine, National Taiwan University,
Department of Clinical Laboratory Sciences and Medical Biotechnology, Taiwan
mtshuwha@ntu.edu.tw
LIN, Chia-Yu
National Laboratory Animal Center,
National Applied Research Laboratories, Taiwan
vetchiayu@nlac.narl.org.tw
LIANG, San-Chi
National Laboratory Animal Center,
National Applied Research Laboratories, Taiwan
simon@nlac.narl.org.tw
MANICKAM, Arun Kumar
Biological Resource Centre, Singapore
arunkumar@brc.a-star.edu.sg
MASUYA, Hiroshi
RIKEN BioResource Center, Japanhmasuya@brc.riken.jp
MOORE, Mark W.
International Mouse Phenotyping Consortium, USA
mwmoore880@comcast.net
MORIWAKI, Kazuo
55

CONTACT LIST

korogi@kumamoto-u.ac.jp
LEE, Han-Woong
Yonsei University (Department of Biochemistry), Korea
hwl@yonsei.ac.kr
LI, Zheng-hua
Institute of Resource Development and Analysis, Kumamoto University, Japanliseika@kumamoto-u.ac.jp
LI, Wanbo
Disease Resource Experimental Animal Center,

CONTACT LISTRIKEN BioResource Center, Japan
moriwaki@brc.riken.jp
MURATA, Takuya
RIKEN BioResource Center, Japan
takuyam@brc.riken.jp
NAKAGATA, Naomi
Kumamoto University, Center for Animal Resources and Development, Japannakagata@kumamoto-u.ac.jp
NAM, Ki-Hoan
Korea Research Institute of Bioscience and Biotechnology, Korea
namk@kribb.re.kr
OBATA, Yuichi
RIKEN BioResource Center, Japanyobata@rtc.riken.go.jp
OKABE, Masaru
Osaka University; Japanokabe@gen-info.osaka-u.ac.jp
OH, Goo Taeg
Ewha Womans University, Laboratory of Cardiovascular Genomics
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Korea
gootaeg@ewha.ac.kr
PARK, Jong Hoon
Sookmyung Women’s University, Korea
parkjh@sookmyung.ac.kr
PONNIAH, Sathivel
Biological Resource Center, Singapore
ponniah_sathivel@brc.a-star.edu.sg
QIN, Chuan
The Chinese Association for Laboratory Animal Science (CALAS)
The institute of Laboratory Animal Science, CAMS&PUMC, China
calas_ie@126.com
SARUKI, Shigefumi
RIKEN Tsukuba Planning Section, Japanssaruki@riken.jp
SEONG, Je Kyung
56

CONTACT LIST

Seoul National University; Korea
snumouse@snu.ac.kr
SERIKAWA, Tadao
Kyoto University; Japan
serikawa@anim.med.kyoto-u.ac.jp
SUZUKI, Tomohiro
Riken BioResource Center, Japansuzukito@brc.riken.jp
TAKABAYASHI, Shuji
Institute for Experimental Animals,
Hamamatsu University School of Medicine, Japan
Shuji@hama-med.ac.jp
TAKEDA, Shuko
The Japanese Association for Laboratory Animal Science (JALAS);
Osaka University Graduate School of Medicine; Japan;
takeda@cgt.med.osaka-u.ac.jp
TERAOKA, Nobuaki
Beijing Office, Riken, China
teraoka@riken.org.cn
WAKANA, Shigeharu
RIKEN BioResource Center; Japanswakana@brc.riken.jp
WANG, Chi-Kuang Leo
National Laboratory Animal Center,
National Applied Research Laboratories, Taiwan
cklwang@nlac.narl.org.tw
WANG, Zhu-Gang
Shanghai Research Center for Model Organisms; China
zhugangw@shsmu.edu.cn
WEAVER, Thomas A.
UK Medical Research Council Harwell; UK
t.weaver@har.mrc.ac.uk
WU, XiaohuiFudan University; China
xiaohui_wu@fudan.edu.cn
57

CONTACT LIST

WURST, Wolfgang
Helmholtz Zentrum München; Germany
wurst@helmholtz-muenchen.de
XIE, Gui-Lin
Chian Biotech, Labzhou Institute of Biological Product, China
guilxie@public.lz.gs.cn
XU, Ping
Shanghai Laboratory Animal Center, Chi-nese Academy of Sciences, &Shanghai SLAC Laboratory Animal Co., Ltd., China
xuping@saccas.com
YANG, Zhi-Wei
Institute of Laboratory Animal Science
Chinese Academy of Medical Sciences, China
YAMADA, Gen
Department of Developmental Genetics Research
Wakayama Medical University, Japangensan7@wakayama-med.ac.jp
YAMAMURA, Ken-ichi
Center for Animal Resources and Development (CARD),
Kumamoto University, Japan
yamamura@gpo.kumamoto-u.ac.j
YAMAZAKI, Yukiko
Genetic Informatics Laboratory, Center for Genetic Resource Information,
National Institute of Genetics, Japanyyamazak@lab.nig.ac.jp
YANG, Xiao
Genetic Laboratory of Development and Diseases,
Beijing Institute of Biotechnology, China
yangx@nic.bmi.ac.cn
YEN, Jeffrey J.Y.
Academia Sinica, Taiwan
bmjyen@ibms.sinica.edu.tw
YOSHIKI, Atsushi
RIKEN BioResource Center; Japan
yoshiki@brc.riken.jp58Model Animal Research Center, Nanjing University
zhaojing@nicemice.cn

59

CONTACT LIST

YU, Dae-Yeul
Korea Research Institute of Bioscience and Biotechnology, Korea
dyyu10@kribb.re.kr
Lianfeng ZHANG
Institute of Laboratory Animal Science
Chinese Academy of Medical Sciences
Peking Union Medical College, Chinazhanglianfeng@cnilas.pumc.edu.cn
ZHAO, Jing

2012
2
AMMRA Annnual Rep
port
Editing Gro
oup/
Chi‐Kuang Leo W
Wang / Hsiaan‐Jean Gen
nie Chin
Yi‐Ling Doreeen Lin / Men
ng‐Feng Rya
an LinPublishhing Date：May, 2013