Table of Contents

Welcome Address

2

AMMRA Current Members

4

Program6
5th AMMRA Council Meeting6

Selected Scientific Program

16

Poster Program

21
32

AMMRA Member List

1

Welcome Address
Dear AMMRA members,
It is a great pleasure for me to welcome all of you to the
5th AMMRA meeting in Taipei. As discussed in the previous meeting held in Kumamoto, we are going to enter
the new phase of AMMRA. I want to discuss several issues
such as membership, obligation, function and goal to start
the new AMMRA. Looking forward to seeing you soon.

Kenichi Yamamura
Chair, Asian Mouse Mutagenesis Resource Association (AMMRA)

2

Welcome Address
Dear friends and Colleagues,
As one of the founding members, it is of great delightand honor for the National Laboratory Animal Center(NLAC) to be the organizer of the 5th AMMRA Annual
Meeting in 2010. Since its foundation in 2000, AMMRA has
been growing steadily and continuously, and the 4 annual gatherings, that evidently manifested greater magnitude ineducation, research and resources one after another; I am
certain that the annual meeting this year will be as fruitful andunforgettable to all of you.
In particular, we are very excited and thrilled to incorporate the 4th AFLAS
Congress Meeting and the 11th CSLAS Annual Meeting with 5th AMMRA Meeting, andthis 3-in-1 event indisputably will present a journey for abundance and refreshment.
Hence, we appreciate the participation and support from all of you, and are sincerely
looking forward to seeing everyone at the International Convention Center in Taipei,
Taiwan in November 2010!

San-Chi Simon Liang
Director General, National Laboratory Animal Center (NLAC), Taiwan

3

AMMRA Current Members
Founding Members
Bio-Evaluation Center of Korean Research Institute of Bioscience and Biotechnology,
Chungbuk
Biological Resource Center, Singapore
Center for Animal Resources and Development of Kumamoto University, Kumamoto
Institute of Laboratory Animal Sciences of Peking Union Medical College, Beijing
National Laboratory Animal Center, Taipei
National Resource Center for Mutant Mice of Nanjing University, Nanjing
Peking University-BLARC, Beijing
Riken BioResource Center, Tsukuba
Shanghai Institute of Biological Sciences of Chinese Academy of Sciences, Shanghai
Shanghai Research Center for Model Organisms, Shanghai

New Joined Members
Institute of Developmental Biology and Molecular Medicine of Fudan University,
ShanghaiLaboratory of Cardiovascular Genomics of Ewha Woman’s University, Seoul
National Institute of Food and Drug Safety Evaluation, Seoul
Seoul National University, Seoul
Sookmyung Women’s University, Seoul
Yonsei University, Seoul

4

Taskforce Committee
Chairperson

Dr. Kenichi YAMAMURA
Center for Animal Resources and Development (CARD) ,Kumamoto University; Japan

Members

Dr. Xiang GAOModel Animal Research Center, Nanjing University, China

Dr. Hyoung-Chin KIM
Korea Research Institute of Bioscience and Biotechnology,
Korea
Dr. Je Kyung SEONG
Seoul National University; Korea

Dr. Chi-Kuang Leo WANG
National Laboratory Animal Center, NARL, Taiwan

55th AMMRA Council Meeting
Monday, November 8, 2010
14:00-17:00

AMMRA Council Meeting (Invited Only)

14:00-14:20

Opening Remark

14:20-15:20

AMMRA related issues

Far Eastern Plaza Hotel

Moderator: Kenichi YAMAMURA(1) Policy(2) CHARTER: Definition, Mission and Goals(3) Other issues that is not covered by the CHARTER
1) Head office2) Website
3) Issues in regards to the membership: enrollment, annual fee, obligation etc.
(4) Integration of the AMMRA into the IKMC
15:20-15:40

Coffee Break

15:40-16:40

Reports from Resource Center

Moderator: Chi-Kuang Leo WANG
(1) The current status of aiding researchers to produce gene-manipulated animals in the Genome Information Research Center, Osaka University
Masaru OKABE(2) Current status of mouse bank in CARD at Kumamoto University.
Naomi NAKAGATA(3) Toward the development of new epistatic mouse model resources
with the next-generation sequencers.
Yoichi GONDO(4) The current status of mouse resources at RIKEN BioResource Center in 2010
Atsushi YOSHIKI
6

(5) Taiwan Mouse Clinic—the current status.
Jeffrey J.Y. YEN(6) The Transgenic Mouse Models Core of NRPGM
Shu-Wha LIN(7) Rodent Model Resource Center – The rodent strain resource service
in Taiwan
Chi-Kuang Leo WANG
16:40-17:00

Discussion

Moderator: Kenichi YAMAMURA
17:30-19:30

AMMRA Welcome Dinner (Invited Only)7

Far Eastern Plaza HotelAbstracts
The current status of aiding researchers to produce gene-manipulated
animals in the Genome Information Research Center, Osaka University
Masaru Okabe
Research Institute for Microbial Diseases, Osaka University, JapanWe are functioning as a core facility to aid researchers in producing gene‐ manipu‐
lated animals in Osaka University. We have been involved in about 200 cases of
producing gene knockout mouse lines and over 400 cases of producing transgenic
mice in the past decade. One of our characteristic procedures is to use our "green"
ES cells. In so doing, if the chimera is infertile, we can take out the testis and ex‐
amine whether or not there is any green fluorescent area in the seminiferous tu‐
bule. If we find such an area, we recover the germ line cells from that fluorescentgreen part and perform ICSI or ROSNI to obtain pups. We have used this procedure
successfully to establish a few lines of knockout mice, saving us from having
to repeat the experiment from scratch.

8

Current status of mouse bank in CARD at Kumamoto University
Naomi Nakagata
Center for Animal Resources and Development, Kumamoto University, 2‐2‐1 Honjo,
Kumamoto 860‐0811, JapanIn CARD at Kumamoto University, our embryo/sperm bank has been managed for the
maintenance of mouse strains as genetic resources since 1998. Our essential services
are: 1) Collection: We have collected over 1500 mouse strains, including mutant andgenetically engineered mice. 2) Cryopreservation: We generally produce embryosfrom these mouse strains using in vitro fertilization. Spermatozoa and over 300
two‐cell embryos for each strain were cryopreserved. 3) Database: Information re‐garding 1,288 strains that we have cryopreserved is available as an online database in
CARD R‐BASE (http://cardb.cc.kumamoto‐u.ac.jp/transgenic/index.jsp<http://cardb.cc.kumamoto‐u.ac.jp/transgenic/index.jsp> ). This information can bealso searched for in IMSR (International Mouse Strain Resource,
http://www.informatics.jax.org/imsr/index.jsp<http://www.informatics.jax.org/imsr/index.jsp> ). 4) Quality control: The quality ofcryopreserved embryos is tested by the development of embryos to normal offspring
after embryo transfer, and subsequent microbial monitoring. 5) Supply: These cryo‐preserved embryos or populations derived from cryopreserved embryos are supplied
to the scientific community. We have supplied 429 strains worldwide.

9

Toward the development of new epistatic mouse model resources with thenext-generation sequencers.
Yoichi Gondo
Team Leader, Mutagenesis and Genomics Team, RIKEN BioResource Center, JAPAN.

We have established the RIKEN ENU Mutant Mouse Libraray1 and have made it open
to research community since 20022. The RIKEN Library encompasses ~3 x 107 point
mutations randomly in the 10,000 G1 mice3 and has been providing allelic series ofpoint mutations of ~10 independent strains per any target gene based on users’ re‐quests4. Many users have been using the RIKEN ENU Mutant Mouse Library as a newreverse genetic resource, namely, a next‐generation gene targeting system5.
Users conducted backcrosses more than 6 generations to make the congenic strain of
the discovered mutations in their target gene and already established various humandisease models; e.g., mental illnesses6, schizophrenia7, pharmacogenetical8 and de‐velopmental malformation9 models.
At present, it is very quick (~6 months) to establish allelic series of mutant strains but
takes more than 2 years to obtain the congenic strains before starting the phenotype
analyses. During the time course of the backcrosses, very useful modifiers and mul‐tigenic effectors are intentionally discarded in vain. Human diseases are mostly poly‐
genic more or less; thus, it is crucial to establish mutant model mice exhibiting epi‐
static interactions. The International knockout mouse consortium (IKMC) has been
establishing model mice of monogenic traits by conventional gene targeting tech‐
nologies. ENU mutagenesis with Mutant Mouse Library should be an effective tool toprovide epistatic model mice, since each G1 mice contains ~3,000 point mutations10.
In order to fully utilize the RIKEN Mutant Mouse Library, we have started to reveal all
the coding mutations in each G1 mouse genome by the next‐generation sequencers
with the whole‐mouse‐exome target sequencing. The first trial using Illumina/SOLiD
with Agilent SureSelect Target Enrichment System discovered 67 ENU‐induced muta‐
tions in one G1 genome by targeting 50‐Mb whole mouse exome. Any modifiers
and/or multigenic effectors, if any in the G1 genome, are likely to be in the discov‐ered 67 mutations because they are coding mutations. Even if such epistatic interac‐10tions are due to non‐coding mutations, then the genomewide 67 mutations should
give rise to the markers for the quick QTL mapping. We are now accepting trial users
to establish epistatic mouse models with respect to the core mutation in their target
gene. This new strategy to reveal epistatic interaction in the mouse genome as anovel bioresource for the human disease modeling will also be presented at the AF‐
LAS11 in details.
1. Sakuraba et al. Biochem Biophys Res Commun 336: 609‐616, 2005.
2. URL; http://www.brc.riken.go.jp/lab/mutants/
3. Gondo et al., Exp Anim 59: 537‐548, 2010.
4. Gondo et al., BMB Rep 42: 315‐323, 2009.
5. Gondo, Nature Rev Genet 9: 803‐810, 2008.
6. Clapcote et al., Neuron 54: 387‐402, 2007.
7. Labrie et al., Hum Mol Genet 18: 3227‐3243, 2009
8. Erickson et al., Biochem Biophys Res Commun 370: 285‐288, 2008.
9. Masuya et al., Genomics 89: 207‐214, 2007.
10. Gondo, J. Genet. Genomics 37: 559‐572, 2010.
11. Makino et al., The 4th AFLAS Congress Meeting, Poster No. B16.

11

The current status of mouse resources at RIKEN BioResource Center in2010
Atsushi Yoshiki
Experimental Animal Division, RIKEN BioResource Center, Tsukuba, Japan
yoshiki@brc.riken.jp, http://www.brc.riken.jp/lab/animal/en
RIKEN BioResource Center (BRC) has collected, preserved, conducted quality control
of and distributed mouse resources since 2002 as the core facility of the National
BioResource Project by the MEXT, Japan. Our mouse resources include over 5,000
strains, such as fluorescent reporters, Cre/Flp‐drivers, conditional floxed/flrted mice,
TET mice which contain a tetracycline‐regulated switch on/off system for the gene
expression, and phenotype‐ and gene‐driven ENU‐induced mutant mice modelinghuman diseases. In collaboration with our Cell Bank we have collected and madeavailable to scientific community gene‐trap knockout resources as embryonic stem
cell clones generated by using a novel poly‐A‐trap strategy, UPATrap. We havecleaned up all the deposited mice free from pathogens by cesarean rederivation orembryo transfer. Genetic modifications and backgrounds are examined by our rigor‐
ous quality control programs. We have distributed since 2002 over 15,400 mouse
resources of the high quality to 732 organizations around the world. Our division
closely collaborates with the Japan Mouse Clinic at RIKEN BRC, a comprehensive
mouse phenotyping platform which can generate standardized phenotypic data forour mouse resources. The RIKEN BRC would like to contribute in the promotion oflife sciences in Asia with the advanced mouse resources of the highest quality.

12

Taiwan Mouse Clinic—the current status
Jeffrey J.Y. Yen, Yen‐Hui Chen, Ya‐Wen Hsaio
Taiwan Mouse Clinic, NRPGM, and IBMS, AS, Taipei, Taiwan
Since May 2008, we have established a comprehensive mouse phenotyping core fa‐
cility in Taipei, called Taiwan Mouse Clinic, to promote local biomedical researches
using the mouse as model by the funding through the National Research Program on
Genomic Medicine (NRPGM), NSC, Taiwan. The key component of this project is theestablishment of the Mouse Hotel which honors the health certificates from all
mouse vivaria and only requests a minimum essential specific pathogen list andgreatly reduces the turn‐around time of animal trafficking within mouse clinic. All
animals in hotel are all‐in and all‐out and are handled as if in P2 vivarium, and bothanimals and equipments in phenotyping laboratories are monitored for pathogen
contamination routinely. In the past one and half year there are more than 90 labor‐
atories all over Taiwan requested our services and the regular services have grown up
to 3000 items per month and have completed above 60,000 cases.

13

The Transgenic Mouse Models Core of NRPGM
Shu‐Wha Lin
College of Medicine Taiwan National University, Department of Clinical Laboratory
Sciences and Medical Biotechnology, Taipei, Taiwan
Mouse is one of the most important tools in dissecting human gene functions. The
applications of mouse embryonic stem (ES) cell technology by thousands of laborato‐
ries over the last 20 years have made huge progress in this field. Prof. Shu‐Wha Lin of
the College of Medicine’s Department of Clinical Laboratory Sciences and Medical
Biotechnology and her research team started using gene knockout mice to conduct
research into gene functions in 1995. The team ultimately spawned a special re‐search team dedicated to animal models for human diseases. Prof. Lin also began
working with the Center for Genomic Medicine at National Taiwan University on theplanning and establishment of the Gene Knockout Mouse Core Laboratory in 2002.
With these experiences, the team earned herself the support from the National Re‐
search Program for Genomic Medicine (NRPGM) and has become a national core tohelp the researchers in Taiwan since 2005. The core facility is established for services
on generating knockout mice and for developing techniques for that purpose. Since
then, the core has successfully created over 110 varieties of genetically‐manipulated
mice and has 80 more strains to accomplish. Underscoring the international acclaim,
the team has earned several international contracts for providing gene targeting ser‐vices.

14

Rodent Model Resource Center – The rodent strain resource service in
TaiwanChi‐Kuang Leo Wang
National Laboratory Animal Center, National Applied Research Laboratories, Taipei,
TaiwanAs the national resource center of laboratory animals in Taiwan, the National Labor‐
atory Animal Center (NLAC) has been dedicated to fulfilling the nation’s need on la‐boratory animals since 1994. In order to further facilitate the biomedical studies
using genetically modified rodents, the Rodent Model Resource Center (RMRC), sub‐ordinate to NLAC, was officially open in 2009 with the ultimate goal to energize local
research through the linkage with global research activities, while most GM rodent
resource related services are maintained by the RMRC operations. Furthermore,
due to the tremendous needs of human disease models for translational medical re‐search, a medical driven mechanism for generating GM model is critical. Thus,
RMRC has initiated a strategic effort for GM model creation. Genes with medical
merit and/or with novel importance to the researchers in Taiwan is the first priority
for disease model production in RMRC. For better utilization, all animal models
generated from this project will be included in the RMRC repository for public searchand sharing. Significant influences to the research and biomedical communities are
greatly expected.

15

Selected Scientific Program for AMMRA Participants
Tuesday, November 9, 2010
08:00-17:00

Registration of Delegates

Lobby, 1F

09:00-09:30

Opening Ceremony

201 BCDE, 2F

09:30-10:40

Keynote Session 1

201 BCDE, 2F

Moderator : Min-Liang KUOFunctional Annotation of the Mouse Genome
Wolfgang WURST
10:40-12:00

Keynote Session 2

201 BCDE, 2F

Moderator : San-Chi Simon LIANG
10:40-11:30 Research Animal Care and Use: Globalization, Harmonization
and Transformation
Kathryn BAYNE
11:30-12:00 Animal Welfare Standards in the 8th Edition of the Guide for
the Care and Use of Laboratory Animals
Lida ANESTIDOU & Janet GARBER
12:00-13:30

Lunch

13:30-14:20

Keynote Session 3

201BCDE, 2F

Moderator : Bon-Chu CHUNG
Transgenic and Stem Cell Technology
Andras NAGY
14:40-17:10

Oral Session 1 : Mutant Rodent Resource

201 BCDE, 2F

Moderator : Chi-Kuang Leo WANG
Xiang GAO
14:40-15:10 NorCOMM, Resources and Tools for Genetic Modeling in Mice
Geoffrey G. HICKS
15:10-15:40 Humanized Mice for Functional Genomics and Human Disease
Model
Kenichi YAMAMURA
15:40-16:10 Advanced Mouse Resources at RIKEN BioResource Center
Atsushi YOSHIKI
16

16:10-16:40 Mutant Rat Resources at National BioResource Project – Rat inJapan
Tadao SERIKAWA
16:40-17:10 Mutant Mouse Resource in China
Xiang GAO
17:30-20:00

Welcome Reception

Banquet Hall, 3F

Wednesday, November 10, 201008:30-09:00

Morning Refreshment

09:00-09:50

Keynote Session 4101, 1F
201 BCDE, 2F

Moderator : Chia-Hung Frank MAO
Current Challenges to Accurate Microbiologic Surveillance of
Research Animals
William R. SHEK
10:00-11:00

Special Topic Lecture 1

202, 2F

Moderator : Si-Tse JIANG
Mouse Sperm and Embryo Cryopreservation
Naomi NAKAGATA
11:00-12:00

Special Topic Lecture 2

202, 2F

Moderator : Si-Tse JIANG
Chimeras and Tetraploid Complementation Assay
Andras NAGY
12:00-13:30

Lunch

13:30-16:30

Oral Session 7 : Rodent Models for Biomedical Research 201 BCDE, 2F
Moderator : Huey-Kang SYTWU
Je Kyung SEONG

13:30-13:55 Integrated Growth Factor Signalling Regulates Urogenital/Reproductive Organ Formation; A General Hint to Think
About Organ Development
Gen YAMADA
13:55-14:20 Circadian Rhythms and Animal Models
Ying XU
14:20-14:45 A Crucial Role of RNA Helicase Rig-I in IgG3 Production andNfkb1/p105 Translation17

Zhu-Gang WANG
14:45-15:10 Molecular and Genetic Investigation on Autoimmune Diabetes:
From Mechanism Dissection to Clinical Application
Huey-Kang SYTWU
15:10-15:35 Role of SNUR4 on Adipogenesis and Osteogenesis, Lessons
from SNUR4 KO Mice
Je Kyung SEONG
15:35-16:00 The Gene-Manipulated Animals and Research in Mechanism of
Fertilization
Masaru OKABE
16:00-16:25 Intravital Molecular Imaging of Cellular Processes in Live Mice
Liqin CAO
Thursday, November 11, 201008:30-09:00

Morning Refreshment

09:00-09:50

Keynote Session 5

101, 1F
201 BC, 2F

Moderator : Chi-Kuang Leo WANG
The Establishment on an International Mouse Phenotyping
Consortium to Develop an Encyclopedia of Mammalian Gene
Function
Mark W. MOORE
10:00-12:00

Oral Session 10 : Laboratory Animal Advanced Technology

201 BC, 2F

Moderator : Chi-Kuang Leo WANG
Xiao-Hui WU
10:00-10:25 Cryopreservation of Mouse Embryos and Spermatozoa andTheir Application
Naomi NAKAGATA
10:25-10:50 Recent Technical Advancements of Nuclear Transfer in the
Mouse
Atsuo OGURA
10:50-11:15 Mammalian Genetic Manipulations with the PiggyBac Transposon
Xiao-Hui WU
18

11:15-11:40 Lentiviral Vector Mediated Transgenesis and Its Application in
Mouse Genetics
Masahito IKAWA
11:40-12:05 Gnotobiology for Laboratory Animal Sciences: How Should We
Utilize Intestinal Microbiota
Kikuji ITOH
10:00-12:00

Oral Session 11 : Mouse Phenotyping

102, 1F

Moderator : Pin OUYANG
10:00-10:50 Epithelial Identity and Differentiation: Insight into the Functionof PNN
Stephen P. SUGRUE
10:50-11:15 4-1 BB (CD137), a TNF Receptor Superfamily, Deficiency Reduces Atherosclerosis in Hyperlipidmic Mice
Goo Taeg OH
11:15-11:40 Focused-Ultrasound Brain-Drug Delivery: Integration with
Nanomedicine Platform
Tzu-Chen YEN
11:40-12:05 Taiwan Mouse Clinic - An Experiment for Phenotyping Service
Jong-Young Jeffrey YEN
12:00-13:30

Technician Lunch & Learn

102, 1F

Sponsored by E Joy 2 Corp
13:30-14:20

Keynote Session 6

201BC, 1F

Moderator : Jong-Young Jeffrey YEN
Large-Scale Mouse Genetic Infrastructure: Programs at the
UK Medical Research Council
Thomas A. WEAVER
14:40-16:40

Mini-Symposium 5 :Trends in Large-Scale Mouse
Phenotyping Program in Asia
Moderator : Shigeharu WAKANA
Si-Tse JIANG
Introduction of the Japan Mouse Clinic
Shigeharu WAKANA
19

102, 1F

Introduction of Taiwan Mouse Clinic
Jong-Young Jeffrey YEN
Mouse Phenotype Networking in Korea
Je Kyung SEONG
Introduction of China Mouse Phenotyping Program
Xiang GAOA Large-Scale Mouse Phenotyping Program in China
Xiao-Hui WU
Recent Activity of IMPC and AMPC Initiative
Shigeharu WAKANA
16:40-17:40

Special Topic Lecture 3102, 1F

Moderator : Si-Tse JIANG
Modified-SHIRPA: High-Throughput Screen Method to Analyze
Mouse Morphhology and Behavior Phenotypes
Hiroshi MASUYATomohiro SUZUKI

20

Poster Program
Tuesday, November 9, am 9:00 to Thursday, November 11, pm 13:30
Category

Poster Number

Animal Models for Biomedical Research

A1 ~ A49

Facility Management, Animal Welfare, and Rodent Resource

B1 ~ B20

Laboratory Animal Technologies

C1 ~ C27

Nonclinical Animal Testing

D1 ~ D48

Quality Control

E1 ~ E23

Animal Models for Biomedical Research ( A1 ~ A49 )Poster
Paper Title
Number
A1 Development of a Novel Immunodeficient Mouse Strain, B10.S/SgSlc‐Prkdcpiy
A2Mechanistic Interaction Between Diabetes Mellitus and Alzheimer Disease: Gener‐
ation of Novel Transgenic Mouse Models of Alzheimer Disease with Diabetes

A3

Loss of Erc/Mesothelin Gene Decreased the Growth of Renal Tumors in Tsc2
Knockout Mice
A Novel CHD7 Mutation in Mice Causes Midline Developmental Defects

A4
A5
A6
A7

A8
A9

Protein Phosphatase 2A Catalytic Subunit Alppha is Essential for Normal Erythro‐poieses in the Mouse Fetal
Systemic POMC Overexpression Increased Visceral Fat Accumulation in C57BL/6
Mice
A Novel Trimeric Collagen Scaffold Molecule, BDL‐F, and Its Functional Assay on
TNF‐Alpha Over‐Expressing Cells and Collagen Antibody‐Induced Arthritis in
DBA/1J Mice
Analysis of Murine Matrix Metalloproteinase 9 Transgene Integration and Gene
Expression in Mice
Establish and Analysis of Mesenchymal Stem Cells from Green Fluorescent Protein
Transgenic Mouse

21

PosterPaper Title
Number
A10 The NF‐κb Binding Sites Play the Role in 2.2 κb Human Matrix Metalloproteinase 9
Gene Promoter Region Induced by TNF‐α
A11
A12
A13

A14
A15

Study on Embryo Transfer in Thalassemia Transgenic Mouse at National Laboratory
Animal Center
All Endocrine Cell Populations Are of Polyclonal Origin As Shown by a Direct in SITU
Demonstration in EGFP/BALB/c Chimeric MicemTOR Inhibition by Rapamycin Exacerbates the Blood Glucose Homeostasis but
Prevents Against Obesity State in KK/H1J Mice Fed a High Fat Diet
Peroxiredoxin I Inhibits K‐RasG12D‐Driven Lung Carcinogenesis in Mice Via Redox
Neutralization
Applications of Microdialysis Coupled with Atomic Absorption Spectrometry and
High‐Performance Liquid Chromatography in the Determination of Brain Trace
Element and Oxidative Levels in Gerbils During Focal Cerebral Ischemia

A16

The Establishment of Hyperoxia‐Induced Acute Lung Injury (ALI) Mouse Model andthe Assessment of rhED‐SOD Treatment to Protect Lung Injury

A17

Easy Applicable Model of Ischemia and Reperfusion on Lung Transplantation

A18

Prominent Expression of Laminin γ3 in Leydig Cells is Nonessential for Mouse Fer‐
tilityPlzf Controls Body Weight in Mice Abstract

A19
A20

Immunological Aspects and Therapeutic Significance of an Aitonantibody Against
Histone H1 in a Rat Model of Concanavalin A‐Induced Hepatitis

A21
A22

Production of Optimum Humanized Mouse Model for Familial Amyloidotic Poly‐neuropathy
Cisd2 Mediates Brown Adipose Tissue Metabolism and Thermoregulation

A23

SNUR4 Inhibition Decrease Fat Mass and Improves Insulin Sensitivity

A24

Phenotypic Effects of Cisd2 Deficiency on Cardiac and Skeletal Muscles in Tis‐

A25

sue‐Specific Knockout Mice
Chemotherapeutic Effects of Resveratrol on Fatty Liver and Hepato‐Carcinogenesis
in HBx Transgenic Mice22

PosterPaper Title
Number
A26 Molecular Process of Hepatocellular Carcinoma in HBx tg Mice Revealed by Gene
Expression Profiling and Functional Analysis
A27

Genomic Analysis of Insulin‐Sensitive Tissues from Anti‐Diabetic Drug Treated ZDF
Rats, T2DM Animal Models

A28

The Role of Cisd2, a Mitochondrial Protein, in Adipogenesis of the Mouse

A29

Anticancer Activities of Furanopyrimidine Aurora Kinase Inhibitors

A30

Neural Stem Cells Promote Motor Function Recovery on SAMP8 Mice Subjected toTraumatic Brain Injury
Pharmacologically Enhanced Imaging of 18F‐FDG Pet for Evaluation of Parkinson's
Disease in Rats
Positional Cloning of a Spontaneous Coat Color Mutation of C57BL/6 Mice and a
Novel SNP on Chromosome 2
The Modulation of Hepc1 on cTnTR141W Transgenic Mice

A31
A32
A33
A34

The Development of Transgenic Rat Models Harboring Cre/loxP Recombination
SystemA35

The Effect of Human Adipose Tissue‐Derived Mesenchymal Stem Cells on Avas‐
cular Necrosis of the Femoral Head in Nude Rats

A36

Polymyositis with Severe Macrophage Infiltration in a Cynomolgus Monkey

A37

Primary and Secondary Infections of Dengue Virus Serotype 3 and Serotype 2 inPigtailed Macaques (Macaca nemestrina)

A38

The WHHLMI Rabbit as a Model Animal for Coronary Spastic Angina

A39

The Analysis of In Vitro Protein Expression Profiles of Tilapia (Oreochromis mos‐sambicus) Testes after Administration of Gonadotropins by Using Two‐Dimensional(2D) Gel Electrophoresis

A40

The Analysis of Cell Cycle Stages and Transplantation of Zebrafish Embryonic Cells
Expressed Green Fluorescent Protein in Zebrafish (Danio rerio)

A41

Alteration of Cardiac Parameters and Myocardial Injury Induced by Whole Body

A42

Hyperthermia in Pigs
Challenge and Polymorphism Analysis of the Novel a (H1N1) Influenza Virus toNormal Animals
23

PosterPaper Title
NumberA43 Experimental Study on Hepatitis C Virus (HCV) Infection in Tupaia belangeri
A44

Application of Recombinant Leptin and Its Receptor Protein

A45

A Review on Domestic Laboratory Mini Pig Models of Circulatory Diseases

A46

Application Prospect of Miniature Pig for Animal Model of Human Disease in Bio‐
medical Research
Genomics Assessment of Functional Food and Traditional Drug Using Monkey
Model

A47
A48

Genomics Assessment of Nanomaterials in Monkeys: Effect in Alteration of Ma‐
crophage Function and Immune System

A49

Assay of Inflammatory Bowel Diseases on Rodent Model of Inflammatory Colitis

Facility Management, Animal Welfare, and Rodent Resource ( B1 ~ B20 )Poster
Paper Title
NumberB1 Evaluation of Individually Ventilated Cage System: Temperature and Relative Hu‐
midity of Intra‐Cage Environment
B2
B3
B4
B5
B6

Personnel Training in Performing Clinical Assessing the Health and Condition ofRodents
Medetomidine, Midazolam and Butorphanol Anesthesia in the Rat and Its Reversal
Using Atipamezole
Efficiency of Double Layer Paper Box with Wire Mesh for Transportation of Labor‐
atory Animal
Ethical Concept on Laboratory Animal Use in Turkey
Felasa “C” Category Laboratory Animal Training in Turkey

B7

Effect of Environmental Enrichment Program Change to Urinary Cortisol Level in
Cynomolgous Monkeys (Macaca fascicularis)

B8

Total Quality Management Improves Laboratory Animal Health, Use and Facility

B9

Environment in a Medical Center
Evaluation of Ozone Sterilization of an Animal Facility
24

PosterPaper Title
Number
B10 Reproductive Performance Index of Outbred Wistar Rat in 41st ‐ 50th Generation at
National Laboratory Animal Center, Mahidol University
B11

Laboratory Animal Rooms Building Energy Modeling Analysis

B12

CFD (Computational Fluid Dynamics) Analysis of Animal Rooms for Gnotobiotic
Mini‐Pigs
Effects of Proton Beam on Mouse Embryos
Cryopreservation Utlilizing a Vitrification Spatula: A Cost Effective Tool for Mouse
Colony Management
Breeding Strategy for Gene Targeting Chimera Mouse in National Laboratory Ani‐
mal Center (Tainan)

B13
B14
B15
B16
B17

Riken Next‐Generation Gene‐Targeting System with the ENU Mutant Mouse Li‐
brary
Rodent Model Resource Center – The First Rodent Resource Repository in Taiwan

B18

Development of Web‐Based Database "Pheno‐Pub" for Analyses and Browse ofComprehensive Phenotyping Data in Japan Mouse Clinic

B19

Current Progress of Comprehensive Mouse Phenotype in Japan Mouse Clinic

B20

The International Association of Colleges of Laboratory Animal Medicine: A Global
Demographic Survey of Diplomate Practices and Trends Across Colleges

Laboratory Animal Technologies ( C1 ~ C27 )Poster
Paper Title
NumberC1
Sperm Preincubation Using Methyl‐Beta‐Cyclodextrin Brings about a High Fertiliza‐tion Rate for Fresh and Frozen‐Thawed Sperm in Two Substrains of 129 Mice
C2

Combined Genetic and Pharmacological Approaches for Cognitive Functions

C3

Factors Affecting the Outcome of Mouse ICSI: Factorial Analysis by Genotypes,
Stage of Male Germ Cells and Freeze‐Thawing Treatment

C4

Granulosa Cell Tumor in Ovaries of a Young Swiss Mouse
25

PosterPaper Title
NumberC5
An Effective In Vitro Fertilization System to the Reproduction from the C57BL/6J
Frozen Sperm
C6
Genetic Profiling System for High‐Throughput Whole Genome Scan in Mice
C7

Generation of X‐Linked Severe Combined Immunodeficiency (X‐SCID) Rats Using
Zinc Finger Nuclease Technology

C8

Taiwan Mouse Clinic – National Phenotyping Center

C9

C11

Designing a C57BL/6 v.s. 129 Speed Congenic Panel Using Microsatellite Markers toAssist Production of Congenic Mice
Breeding Status of Laboratory Syrian Hamster Colony Established at National La‐
boratory Animal Centre, Thailand
Acute Renal Toxicity Study of Melamine and Cyanuric Acid Combination in Rats

C12

Safety Evaluation of SMA‐Nanosilver in Mice

C13

Safety Evaluation of Hybrid Genetically Modified Papaya Fruits in Taiwan

C14

Evaluation the Efficacy of BALB/cAnN.Cg‐Foxn1nu/CrlNarl Mating Strategy in IVC
SystemProduction, Purification and Functional Characterization of Recombinant Canine
Follicle‐Stimulating Hormone
Services of Cryopreservation, Rederivation and Genotyping by National Laboratory
Animal Center, Tainan
A Technique Platform for Pre‐Clinical Development of Hybridoma Cells: Molecular
Cloning of Target Immunoglobulin Genes, Serum‐Free Expression of Therapeutic
Antibodies and Ab/Ag Binding Kinetic Analysis
Generation of Induced Pluripotent Stem Cells in Rabbits

C10

C15
C16
C17

C18
C19
C20

C21
C22

Expression of Capsid Protein of a Newly Identified Rat Parvovirus and Application in
Serodiagnosis of RPV Infection
The Development of the PCR Assays for Mouse Parvovirus (MPV) and Minute Virusof Mice (MVM), and the Surveillance of MPV and MVM Infection in Laboratory
Mice in Taiwan
The Culture Conditions of Differentiating Osteoblasts from Murine Mesenchymal
Stem Cells
Embryo Transplantation in Rabbit
26

PosterPaper Title
Number
C23 Preliminary Study of Gene Targeting in Tibet Minipig Fetal Fibroblasts
C24
C25
C26
C27

Molecular Cloning and Prokaryotic Expression of Partial Leptin Receptor Extracel‐lular Domain of Tibet Minipig
Targeted Manipulation of Cellular Genomes Using Designed Zinc Finger Nucleases
A New Depression‐Like Behavior Mouse Model Induced by Reserpine Injection
Alone or in Combination with Electrical Stimulation
Assay of Inflammatory Bowel Diseases on Rodent Model of Inflammatory Colitis

Nonclinical Animal Testing ( D1 ~ D49 )Poster
Paper Title
Number
D1 A 28 Days Subacute Toxicity Study of 188Re‐BMEDA‐liposomes in Rats
D2

The 14‐Day Repeated Dose Toxicity Study of Recombinant Human Factor IX in Rats

D3

The Multiple‐Dose Pharmacokinetics of Recombinant Human Factor IX in Rats

D4

Hydrogel Contained Chestnut Honey Accelerates Diabetic Ulcer Healing in db/db
Mice
Safety Evaluation of Extracellular Polysaccharopeptides Produced from Trametes
versicolor LH‐1 Submerged Culture in Mice

D5
D6

Bioactivity Evaluation of Medical Grade PVC Compound for Insufflation Tubing

D7
D8

A Kindling Model of Temporal Lobe Epilepsy in Rhesus macaque Induced by Coria‐
ria Lactone
Subacute (28‐Day) Oral Toxicity Study in Rats Fed with ELGUCARE

D9

Evaluation Study of Hepaprotection Function of Bpogen

D10

Studies on Brain and Lung in Cynomolgus Monkeys Exposure to Welding Fumes by
the Inhalation
Memory Enhancement and Antiamnesic Effect by Bing‐Han Seng Ler Capsule in
Mice

D11

27

PosterPaper Title
Number
D12 Neutralizing Antibodies as a Key Protective Mechanism During Chronic SHIV Infec‐
tion in CD8+ T‐Cell‐Depleted Macaques
D13

Characteristics of Circle of Willis Variations in the Mongolian Gerbil and a Newly
Established Ischemia‐Prone Gerbil GroupD14

The Expression and Significance of Vascular Endothelial Growth Factor in the Acute
Rejection Reaction of Orthotopic Liver Transplantation in Rats

D15

In vivo Study on Immune‐Modulation Function of Li Te Antrodia camphorate

D16

The Preliminary Study on EKM‐Gene Therapy of AIDS Rhesus Monkeys Model

D17

Contact Hypersensitivity Response by Presensitization with Alpha‐Hexyl Cinnamal‐
dehyde and Histologic Findings in ICR Strain Mice

D18

Animal Models for Evaluating Immunogenicity of Polysaccharide‐Protein Conjugate
Vaccines
Chromium Supplementation Attenuates Development of Obesity in C57BL/6J Mice

D19
D20

Fed a High‐Fat Diet
Chromium Supplementation Reduced Atherosclerosis Lesions in ApoE‐Knockout
Mice

D21

The Immuno‐Regulatory Effects of rh‐EGF on LPS‐Induced Sepsis Mice

D22

Endocrine Disrupting Activity Induced by Benomyl and Carbendazim in theThree‐Generation of Rats
Thiabendazole Might Exhibit Antagonistic Effect on Mammary Gland Tumor In‐
duced by 17ß‐Estradiol in Wistar Rats

D23
D24

Androgen Receptor Mediated Developmental Toxicity and Endocrine Disrupting
Activity Induced by Benomyl and Carbendazim with Whole Embryo Culture of Rats

D25

Effects of Routes of Fructose Consumption on C57Bl/6J Mice

D26

Effect of Arctium lappa L. in the Dextran Sulfate Sodium Colitis Mouse Model

D27

Application of ivGTT Model for Drug Screening of Anti‐Diabetic (Type 2) Herbal
Medicine
13‐Weeks Subchronic Oral Toxicity Study with Polygonum Multiflorum Thunb. in
Rats

D28

28

PosterPaper Title
Number
D29 6,7‐di‐O‐Acetylsinococuline (FK‐3000) Induces G2/M Arrest in MDA‐MB‐231 Breast
Carcinoma Cells Through p38MAPK Phosphorylation and cdc25B Dephosphoryla‐tion
D30 FK‐3000 Isolated from Stephania delavayi Diels. Inhibits Breast Cancer Cell Prolife‐
ration by Suppressing NF‐κB and COX‐2
D31

Antiproliferative Effects of Phenolic Compounds Isolated from Brazilian Propolis

D32
D33
D34

Effect of Kaerophyllin on Collagen Induced Arthritis in Rats
Vitatin, a Soybean Fermentation Product, Attenuates Nonalcoholic Fatty Liver ofHyperlipidemic Hamsters
Urocortin Reduces Intracerebral Hemorrhage‐Induced Injury in Rats

D35

Efficiency of Chinese Herbal Medicine HM‐02 on Blood Glucose and Blood Lipid
Modulation in Type II Diabetic Mice Induced with High Fat Diet

D36
D37

The Influences of Organic and Inorganic Selenium Compounds on Proteomic Ex‐pression and Oxidative Stress in Aged Mice Brain
The Protective Effects of Osmanthus fragrans Flower Extract on Brain Monoamine
Oxidase and Oxidative Stress of OVA‐Immunized Mice

D38

Antioxidative Effects of Propofol in Alloxan‐Induced Diabetic Mice

D39

Detection of Anti‐Drug Antibodies (ADAS) Against Therapeutic Protein in Colla‐
gen‐Induced Arthritis (CIA) Animal Model

D40

Human Anti‐HSV‐1 Monoclonal Antibody Prevent Mice from Herpes Simplex Virus
Type 1 Infection
The Effects of Resveratrol on Atherosclerosis in ApoE‐Deficient Mice

D41
D42

Study of Rapamycin Combined 5‐Fluorouracil in Treatment of Colorectal Tumor in
BALB/cByNarl Mice Bearing CT‐26 Tumor Cells

D43
D44

Anti‐Tumor Efficacy and Mechanism Studies of the Antrodia Camphorata from
Fermented Mycelium
Amelioration of Dextran Sulfate Sodium‐Induced Colitis by Oral Bacteroides fragilis

D45

in Grem‐Free Mice
The Ant‐Inflammatory Effects of Ganoderma Tsuge on the Heatstroke of Rats

29

PosterPaper Title
Number
D46 Cellular Immunity of Germ‐Free Mice Induced by Bacteroides fragilis
D47

D48

Assessing the Effect and Proper Drug‐Light Interval of Chlorin E6 for Light‐Emitted
Diode Photodynamic Therapy by Using Murine Melanoma Expressing Green Fluo‐
rescence Protein
The Anti‐Inflammation Effect of Chlorogenic Acid in Dextran Sulfate Sodium(DSS)‐Induced Experimental Mouse Colitis

Quality Control ( E1 ~ E23 )Poster
Paper Title
Number
E1
Serum Proteomic Signatures of Laboratory Rats Housed in Individual Ventilation
Cages VS. General Diluting Ventilation Cages
E2

Studying Technique for Genetic Monitoring in Outbred Stock Zebrafish

E3

Use of a Probe to Detect Five Common Laboratory Rodent Parvoviruses in Cell Cul‐
ture
Evaluation the Efficacy of Pathogens Detection in IVC System by Soiled‐Bedding
Sentinel Program
Application of Polymerase Chain Reaction to Detect Corynebacterium bovis Asso‐
ciated with Hyperkeratotic Dermatitis of Athymic Nude Mice

E4
E5
E6

Malignant Schwannoma in Heterozygous BALB/cMlac Nude Mouse

E7

Carcinosarcoma in Heterozygous BALB/cMlac Nude Mouse

E8

Distribution of Unidentified Helicobacter Spp. in the Gastrointestinal Tract and the
Hepatobiliary System of Laboratory Mice

E9
E10
E11

A Survey of Microbilogical Status of Laboratory Rats and Mice in Taiwan During
2008‐2009
Monitoring of Health Status in Inbred and Outbred Mice at the National Laboratory
Animal Center, Mahidol University, Thailand
Serum Chemistry Value in 2009 of Sprague‐Dawley Rat at the National Laboratory
Animal Center, Mahidol University, Thailand
30

PosterPaper Title
Number
E12 Establish a Procedure for Detecting Campylobacter jejuni by Culture Method in La‐
boratory Rodents
E13 Mutual Recognition of Laboratory Animal Facility Accreditation Results and Role of
Accreditation Bodys
E14 Characterization and Genetic Diversity Analysis of Microsatellite DNA in Tree
Shrews (Tupaia belangeri chinensis)
E15
E16
E17
E18

Investigation on Etiopathogenisis and Disease Control in a Large‐Scale Dysenteria
Outbreak in Cynomolgus
Development and Characterization of Eight Novel Microsatellite Markers from
Guinea Pig (Cavia porcellus)
The Distribution of Microorganisms in Laboratory Mice and Rats of Animal Facilities
in Korea
The Comparison of Blood Physiological and Biochemical Parameters Between
Three Kinds of Mini Pigs in Guangzhou

E19

Surveillance of Murine Norovirus in Japan

E20

Development of Genetic Markers in Common Marmoset

E21

Age‐Related Changes in Serum Chemistry and Hematology Values of C57BL/6JNarl
Mice
Automated Analysis of HomeCageScan to Identify Based Behaviour in Mice

E22
E23

Eradication of Helicobacter and Mouse Norovirus Using Neoatal Transfer with Hy‐
pochlorous Acid Immersion

31

AMMRA MEMBER LISTARAKI, Kimi

GANDO, Yoichi
RIKEN BioResource Center, Japan

IRDA, Kumamoto University, Japan

gondo@brc.riken.jp

arakimi@gpo.kumamoto-u.ac.jp
ARAKI, Masatake

IKAWA, Masahito
Research Institute for Microbial Diseases,

IRDA, Kumamoto Universit, Japan

Osaka University, Japan

maraki@gpo.kumamoto-u.ac.jp

ikawa@biken.osaka-u.ac.jp

CHIN, Hsian-Jean
National Laboratory Animal Center, Na-IWAKURA, Yoichiro
Center for Experimental Medicine and Sys-

tional Applied Research Laboratories; Tai-tems Biology,Institute of Medical Science,

wan

University of Tokyo, Japan

geneichin@nlac.narl.org.tw

iwakura@ims.u-tokyo.ac.jp

CHUNG, Bon-Chu
Institute of Molecular Biology, Academia

HICKS, Geoffrey

Sinica, Taiwan

University of Manitoba; Canada

mbchung@sinica.edu.twhicksgg@cc.umanitoba.ca

DENG, Hongkui

JIANG, Si-Tse

Department of Cell Biology

National Laboratory Animal Center, Na-

The college of Life Sciences, Peking Uni-tional Applied Research Laboratories; Tai-

versity, China

wanhongkui_deng@pku.edu.cn

stjiang@nlac.org.tw

FEI, Jian

KAKUTA, Shigeru

Shanghai Research Center for Biomodel

Center for Experimental Medicine and Sys-

Organism,China

tems Biology,Institute of Medical Science,

Jfei@sibs.ac.cn

University of Tokyo, Japan
kakuta@ims.u-tokyo.ac.jp

GAN, Ke
Model Animal Research Center, Nanjing

KANEDA, Hideki

University, China

RIKEN BioResource Center, Japan

ganke1131105@163.com

hkaneda@brc.riken.jp

GAO, Xiang
Nanjing University; China
gaoxiang@nju.edu.cn

32

KANG, Hoil

LIN, Shu-Wha

National Institute of Food and Drug Safety

College of Medicine Taiwan National Uni-

Evaluation,Korea Food and Drug Adminis-

versity, Department of Clinical Laboratory

tration, Korea

Sciences and Medical Biotechnology, Tai-

kanghoil@korea.kr

wanmtshuwha@ntu.edu.tw

KATOH, Hideki
Institute for Experimental Animals, Hama-

LIN, Chia-Yu

matsu University School of Medicine, Japan

National Laboratory Animal Center, Na-hideki-k@hama-med.ac.jp

tional Applied Research Laboratories; Taiwan

KIM, Hyoung-Chinvetchiayu@nlac.org.tw

Korea Research Institute of Bioscience andBiotechnology, Korea

LIANG, San-Chi
National Laboratory Animal Center, Na-hckim@kribb.re.kr

tional Applied Research Laboratories; Tai-

KOROGI, Rie
Institute of Resource Development andwan

Analysis, Kumamoto University, Japansimon@nlac.org.tw

korogi@kumamoto-u.ac.jp

MANICKAM, Arun Kumar
Biological Resource Centre, Singapore

LEE, Han-Woong
Yonsei University (Department of Biochemistry), Korea

arunkumar@brc.a-star.edu.sg
MASUYA, Hiroshi

hwl@yonsei.ac.kr

RIKEN BioResource Center, Japan

LI, Zheng-hua
Institute of Resource Development andAnalysis, Kumamoto University, Japanhmasuya@brc.riken.jp
MOORE, Mark W.
International Mouse Phenotyping Consor-

liseika@kumamoto-u.ac.jp

tium; USA

LI, Wanbo
Disease Resource Experimental Animal
Center, Institute of laboratory Animal

mwmoore880@comcast.net
MORIWAKI, Kazuo
RIKEN BioResource Center, Japan

Science, Peking Union Medical College andChinese Academy of Medical Sciences,Chinamoriwaki@brc.riken.jp
MURATA, Takuya
RIKEN BioResource Center, Japan

Li_Wanbo2006@yahoo.com.cn

takuyam@brc.riken.jp

33

NAKAGATA, Naomi

SARUKI, Shigefumi

Kumamoto University, Center for Animal

RIKEN Tsukuba Planning Section, Japan

Resources and Development; Japanssaruki@riken.jp

nakagata@kumamoto-u.ac.jp

SEONG, Je Kyung

NAM, Ki-Hoan

Seoul National University; Korea

Korea Research Institute of Bioscience andBiotechnology, Korea
namk@kribb.re.kr

snumouse@snu.ac.kr
SERIKAWA, Tadao
Kyoto University; Japan

OBATA, Yuichi
RIKEN BioResource Center, Japanyobata@rtc.riken.go.jp

serikawa@anim.med.kyoto-u.ac.jp
SUZUKI, Tomohiro
Riken BioResource Center, Japan

OKABE, Masaru
Osaka University; Japanokabe@gen-info.osaka-u.ac.jp

suzukito@brc.riken.jp
TAKABAYASHI, Shuji
Institute for Experimental Animals, Hama-

OH, Goo Taegmatsu University School of Medicine, Japan

Ewha Womans University, Laboratory of
Cardiovascular Genomics, Division of Lifeand Pharmaceutical Sciences, Ewha Wo-

Shuji@hama-med.ac.jp
TAKEDA, Shuko
The Japanese Association for Laboratorymans University, Korea

Animal Science (JALAS); Osaka University

gootaeg@ewha.ac.kr

Graduate School of Medicine; Japan;

PARK, Jong Hoon
Sookmyung Women’s University, Korea

takeda@cgt.med.osaka-u.ac.jp
TERAOKA, Nobuaki

parkjh@sookmyung.ac.kr

Beijing Office, Riken, China

PONNIAH, Sathivel
Biological Resource Center, Singapore

teraoka@riken.org.cn
WAKANA, Shigeharu
RIKEN BioResource Center; Japanponniah_sathivel@brc.a-star.edu.sg

swakana@brc.riken.jp

QIN, Chuan
The Chinese Association for Laboratory

WANG, Chi-Kuang Leo

Animal Science (CALAS); The institute of

National Laboratory Animal Center, Na-

Laboratory Animal

tional Applied Research Laboratories; Tai-

Science,CAMS&PUMC; China

wancalas_ie@126.com

cklwang@nlac.narl.org.tw

34

WANG, Zhu-Gang

YAMAMURA, Ken-ichi

Shanghai Research Center for Model Or-

Center for Animal Resources and Develop-

ganisms; China

ment (CARD) , Kumamoto University; Ja-

zhugangw@shsmu.edu.cn

panyamamura@gpo.kumamoto-u.ac.j

WEAVER, Thomas A.
UK Medical Research Council Harwell; UK

YAMAZAKI, Yukiko
Genetic Informatics Laboratory, Center fort.weaver@har.mrc.ac.uk

Genetic Resource Information, National

WU, XiaohuiInstitute of Genetics, Japan

Fudan University; China

yyamazak@lab.nig.ac.jp

xiaohui_wu@fudan.edu.cn
WURST, Wolfgang

YANG, Xiao
Genetic Laboratory of Development andHelmholtz Zentrum München; Germany

Diseases, Beijing Institute of Biotechnology,

wurst@helmholtz-muenchen.de

China

XIE, Gui-Lin

yangx@nic.bmi.ac.cn

Chian Biotech, Labzhou Institute of
Biological Product, China

YEN, Jeffrey J.Y.
Academia Sinica; Taiwan

guilxie@public.lz.gs.cn

bmjyen@ibms.sinica.edu.tw

XU, Ping
Shanghai Laboratory Animal Center, Chi-

YOSHIKI, Atsushi

nese Academy of Sciences, &RIKEN BioResource Center; Japan

Shanghai SLAC Laboratory Animal Co.,
Ltd., China

yoshiki@brc.riken.jp
YU, Dae-Yeul

xuping@saccas.com

Korea Research Institute of Bioscience andYANG, Zhi-Wei

Biotechnology, Korea

Institute of Laboratory Animal Science,
Chinese Academy of Medical Sciences,

dyyu10@kribb.re.kr
Lianfeng ZHANG

ChinaInstitute of Laboratory Animal Science

YAMADA, Gen

Chinese Academy of Medical Sciences

Institute of Molecular Embryology and Ge-

Peking Union Medical College, China

netics (IMEG), Kumamoto University; Ja-zhanglianfeng@cnilas.pumc.edu.cn

pan

ZHAO, Jing
Model Animal Research Center, Nanjingtransg@kumamoto-u.ac.jp

University

35

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