2023 September 25 (Mon.)GRANSHIP (Shizuoka Convention and Arts Center)

Room A

Room B

Room CRoom D

Room E

Room F

Exhibition

1F Medium Hall - Earth

11F Conference Hall - Winds

6F Reception Hall

10F Conference Room 1001-1&2

9F Conference Room 910

1F Main Hall - Ocean

1F Main Hall - Ocean

9:00

9:30

Short Course Opening Ceremony

10:00

Session 1
Target Protein Degrader (TPD)創薬への挑戦

10:30

Chairs:Harutoshi Kato, Kengo Watanabe
11:00

SC1-1: Mikihiko Naito
SC1-2: Yusuke Tominari
SC1-3: Masaya Shimada

11:30

Luncheon Seminar 2
12:00Chair: Seiji Okuizumi
Speaker: Kenji Nishikawa
Speaker: Masataka Oitate

Host: Tatsuya Matsumi
肝細胞自身が産生する液性因子による肝機能の維持メカニズムについて
Speaker: Yuji Ishida
ヒト肝細胞キメラマウスを用いた
ヒト薬物動態予測の精緻化研究
Speaker: Taiji Miyake

Sponsored by KONICA MINOLTA REALM, INC.

Sponsored by PhoenixBio

細胞内動態解析への挑戦、臓器から細胞レベルのイメージングへ

12:30

13:00

Luncheon Seminar 1

Keynote Lecture
血液脳関門通過の先端テクノロジー

13:30

Chair: Kengo Watanabe
Speaker: Takanori Yokota
14:00

Session 2
創薬モダリティーと評価モダリティーの交差点

14:30

Chairs:Masanori Nagata, Hideo Takakusa
SC2-1: Mitsutoshi Setou
SC2-2: Shunji Imai

15:00

Chairs:Kouhei Kiyota, Masataka Oitate
15:30

SC2-3: Rira Watanabe
SC2-4: Syunsuke Yamamoto
16:00

Session 3
Microphysiological Systems (MPS)の創薬実装

16:30

Chairs:
Shinji Iwasaki, Takashi Ueno
SC3-1: Norikazu Saiki
SC3-2: Kaori Takama
SC3-3: Tomoki Imaoka

17:00

Short Course Closing Ceremony
17:30

18:00

Meeting Opening Ceremony
Plenary lecture 1
An improved approach to P450 reaction
phenotyping

18:30

Chair: Kiyomi Ito
Speaker: R. Scott Obach
19:00

19:15-20:45
19:30

Welcome reception
3F Lobby2023 September 26 (Tue.)

9:00

9:30

10:00

10:30

GRANSHIP (Shizuoka Convention and Arts Center)

Room A

Room B

Room CRoom D

Room E

Room FExhibition

1F Medium Hall - Earth

11F Conference Hall - Winds

6F Reception Hall

10F Conference Room 1001-1&2

9F Conference Room 910

1F Main Hall - Ocean

1F Main Hall - Ocean

Symposium 1

Symposium 2

Symposium 3

Symposium 4

Symposium 5

Regulation DIS

JSSX-organized Asia-pacific symposium #1

DDS DISICCP450

ICCP450

Use and regulation of biomarkers
in drug development

Drug oxidation and metabolism
in pharmacology/toxicology

DDS Development Strategies
for the Creation of Innovative Drugs

Sustainability, biomarker, and bioremediation:
The role of cytochrome P450

Phase II conjugation reactions involved in theregulation of biologically active molecules

Chair: Akihiro Ishiguro
Chair: Kosuke Saito
S01-1: Kosuke Saito
S01-2: Hiroyuki Kusuhara
S01-3: Ryosuke WatariS01-4: Akihiro Ishiguro
S01-5: Yuchen Sun

Chair: Hiroshi Yamazaki
S02-1: Hiroshi Yamazaki
S02-2: Donghak Kim
S02-3: Yune-Fang Ueng
S02-4: Verawan Uchaipichat
S02-5: T. Thanga Mariappan

Chair: Shigeru Kawakami
Chair: Tatsuhiro Ishida

Chair: Hirofumi Ichinose
Chair: Mayumi Ishizuka

Chair: Sinichi Ikushiro
Chair: Katsuhisa Kurogi

S03-1: Hidefumi Mukai
S03-2: Makiya Nishikawa
S03-3: Hidenori Ando
S03-4: Kazunori Shimizu
S03-5: Hiroto Hatakeyama

S04-1: Hisato Iwata
S04-2: Hideyuki Inui
S04-3: Li Ji
S04-4: Elizabeth M.J. Gillam

S05-1: Ming-Cheh Liu
S05-2: Shin Yasuda
S05-3: Mitsuki Kondo
S05-4: Miyu Nishikawa

Poster Set‐up

11:00

Poster Presentation
11:30!P-XXX
12:00

12:30

13:00

Luncheon Seminar 1

Sponsored by SEKISUI MEDICAL CO., LTD.

Symposium 6
14:00

14:30

15:00

17:30

18:00

18:30

19:00

19:30

Symposium 7

Sponsored by Nihon Validation Technologies
CorporationSymposium 8

Introduction of Label-free and Real-time
Transporter Measurement System

BP Award Finalist

Chair: Masateru Miyake
Speaker: Mitsuyoshi Shimane

Viewing posters of participants during theinterview is not permitted.

Sponsored by Nanion Technologies Japan K.K.

Poster Display
Symposium 9Symposium 10

ICCP450

ICCP450

MOC-JSSX Session

Current trends in establishment andimplementation of new regulatory guidelines
related to pharmacokinetics

Frontline Research for Membrane Proteins andEnzymes for Human Diseases

Beyond bone health: Development of novelvitamin D derivatives and vitamin Dhydroxylases

Biophysical Techniques for P450 Studies

Animal models to predict drug metabolism andtoxicity in human

Chair: Akiko Ishii-Watabe
Chair: Naomi Nagai

Chair: Takeo Nakanishi
Chair: Sunhapas Soodvilai

Chair: Toshiyuki Sakaki
Chair: Midori Takimoto-Kamimura

Chair: Masaki Horitani
Chair: Ilia G. Denisov

Chair: Hiroshi Suemizu
Chair: Kaoru Kobayashi

S06-1: Akiko Ishii-Watabe
S06-2: Masayo Hashimoto
S06-3: Mototsugu Ito
S06-4: Ryosuke Kuribayashi
S06-5: Tsuyoshi Kobayashi

S07-1: Soodvilai Sunhapas
S07-2: Takahiro Ishimoto
S07-3: Kyeong-Man Kim
S07-4: Lushan Yu
S07-5: Takeo Nakanishi

S08-1: Fumihiro Kawagoe
S08-2: Kaori Yasuda
S08-3: Rita Ruth Bernhardt
S08-4: Yuu Hirano

S09-1: Ilia G. Denisov
S09-2: Katsumasa Fujita
S09-3: Masaki Horitani
S09-4: Yoshitaka Bessho

S10-1: Hiroshi Suemizu
S10-2: Chise Tateno
S10-3: Yasuhiro KazukiS10-4: Shuiying Hu

Plenary symposium
beloved mentor and a leader incytochrome P450 and biochemistry
Chair: Masahiko Negishi
Chair: Yasushi Yamazoe

17:00

Sponsored by K.K. AB SCIEX

Chair: Ryo Tanabe
Speaker: Yasufumi WadaJSSX BP Award Interview

JSSX-organized Asia-pacific symposium #2

Remembering Tsuneo Omura: A
16:30

Chair: Naokazu Okamoto
Speaker: Kayoko Kanemitsu

Luncheon Seminar 4

Regulation DIS

15:30

16:00

Luncheon Seminar 3

Using plasma 6β-hydroxycortisol/cortisol
Evaluation of antisense oligonucleotides
New drug discovery screening methodology asratio for minimally invasive CYP3A phenotyping pharmacokinetic properties in mice using LCmulti-organ microphysiological system (MPS)
MS/MSand its application to drug-drug interaction
Chair: Shinsuke Aoyama
Speaker: Hiromi Shibasaki

13:30

Luncheon Seminar 2

PS1-1: F. Peter GuengerichPS1-2: Bon-Chu Chung
PS1-3: Ulrich M. Zanger
PS1-4: Rita Ruth Bernhardt
PS1-5: Ken-ichirou Morohashi

Commercial Exhibition

2023 September 27 (Wed.)

9:00

Room A

Room B

Room CRoom D

Room ERoom FExhibition

1F Medium Hall - Earth

11F Conference Hall - Winds

6F Reception Hall

10F Conference Room 1001-1&2

9F Conference Room 910

1F Main Hall - Ocean

1F Main Hall - Ocean

Symposium 11

Symposium 12

ICCP450 P450 Engineering
9:30

10:00

10:30

GRANSHIP (Shizuoka Convention and Arts Center)

Innovations in P450 Engineering:
Recent Advances and Future Directions

Drug Metabolism andDrug Induced Toxicity DIS
Case study on human disproportionate
metabolite and its prediction

Symposium 13

Symposium 14

Drug Absorption DIS

ICCP450DRUG ABSORPTION FROM ZERO:
Keys to Successful PBPK Modeling andSimulation of Oral Drug Absorption

Breaking down boundaries:
Exploring non-P450 oxygenase

Selected Oral Presentation 1

Chair: Osami Shoji
Chair: Hidehiko Hirakawa

Chair: Satoshi Yamaori
Chair: Daigo Asano

Chair: Yoshiyuki Shirasaka
Chair: Toshimichi Nakamura

Chair: Takeshi Uchida
Chair: Masakazu Sugishima

Chair: Yuji Ishii
Chair: Yuu Miyauchi

S11-1:
S11-2: Vlada B. Urlacher
S11-3: Hidehiko Hirakawa
S11-4: Thomas M. Makris
S11-5：Yichi Zhang
S11-6：Victoria Barros Metlova

S12-1: Daigo Asano
S12-2: Shotaro Uehara
S12-3: Kazutaka Sekiguchi
S12-4: Hidetaka Kamimura

S13-1: Yoshiyuki Shirasaka
S13-2: Atsushi Kambayashi
S13-3: Tatsuki Mochizuki
S13-4: Satoshi Asano

S14-1: Jonathan A. R. Worrall
S14-2: Wei-Hau Chang
S14-3: Lennart Brewitz
S14-4: Masakazu Sugishima

SOP1-1: Albert Braeuning
SOP1-2: Tatsuya Sueyoshi
SOP1-3: Dave Arthur Robledo
SOP1-4: Damjana Rozman
SOP1-5: Sayaka Deguchi
SOP1-6: Reiko Watanabe
SOP1-7: Tamana Enami

Luncheon Seminar 5Luncheon Seminar 6

Poster Display

Commercial Exhibition

11:00

Efforts to use and automate Organoid on aNew technology to allow increased sensitivity
chip for more advanced prediction of biologicaland selectivity for the MS imaging offunctions in human bodytherapeutically relevant doses in drug
development
Chairs: Yoko Ejiri, Koji Udagawa
Speakers: Yoko Ejiri, Koji Udagawa
Speakers: Motoji Oshikata, Hiroko Iwasaki

11:30

12:00

Sponsored by Mimetas Japan K.K./Molecular Devices
Japan, LLC.

Sponsored by Nihon Waters K.K.

Luncheon Seminar 7
Successfully executing hAME studies –Insights and experiences from 500 studies
Chair: Anthony Vo
Speaker: John Kendrick
Sponsored by Labcorp Laboratories Japan G.K.

12:30

Poster Presentation

13:00

2P-XXX

13:30

Poster Display
基礎教育コース

14:00

Speaker: Shingo Nagano
Speaker: Tomoya Hino
Speaker: Yusuke Sato

14:30

Language: Japanese only

15:00

15:30

16:00

16:30

17:00

17:30

18:00

18:00-20:00

18:30

19:00

19:30

BanquetHOTEL GRAND HILLS SHIZUOKA 5F "Century Room"The predoctoral Researcher-

JSSX-sponsored event: Industry

Initiative Session（PRIS）2023

Networking Session for Young

Challenges of next-generation researchers tocreate knowledge and skillsResearchers from Industries

Chair: Takumi Sato
Chair: Yoshiki Hashimoto
PSY-EL: Yuu Miyauchi
PSY-1: Ryo Nakamura
PSY-2: Hiroki Sunakawa
PSY-3: Takumi Tanaka
PSY-4: Yasuhito Tsukushi
PSY-5: Takumi Iwasaka
PSY-6: Reiya Yamashita

Advance registration required, Language:
Japanese only.

Rapid Fire Talk
KONICA MINOLTA REALM
Shin Nippon Biomedical Laboratories
WuXi AppTec JapanSOLVO Biotechnology
KAC
Central Institute for Experimental Animals

2023 September 28 (Thu.)

9:00

9:30

GRANSHIP (Shizuoka Convention and Arts Center)

Room A

Room B

Room CRoom D

Room E

Room F

Exhibition

1F Medium Hall - Earth

11F Conference Hall - Winds

6F Reception Hall

10F Conference Room 1001-1&2

9F Conference Room 910

1F Main Hall - Ocean

1F Main Hall - Ocean

Symposium 15
Drug Metabolism andDrug Induced Toxicity DIS
Frontiers of drug metabolism/toxicity studies using novel in vitro
and in silico evaluation systems

Symposium 16

Symposium 17

Symposium 18

Symposium 19

ICCP450

BioAnalysis and BioImaging DIS

Transporter DIS

ICCP450

Structure and Chemistry of the P450 System

Single-cell analytical techniques
to visualize detailed pharmacokinetics

Future perspectives
in transporter-driven drug development

Neonicotinoids and P450;
metabolism of neonicotinoids in insects, fungi,vertebrates, and humans

10:00

Chair: Kousei Ito
Chair: Yoshiteru Kamiyama

Chair: Shingo Nagano
Chair: Emily E. Scott

Chair: Hideo Takakusa
Chair: Kosuke Saito

Chair: Sumio Ohtsuki
Chair: Kazuya Maeda

Chair: Satoshi Yamaori
Chair: Hirofumi Ichinose

10:30

S15-1: Ryuji Kato
S15-2: Akinori Takemura
S15-3: Kazuya Maeda
S15-4: Yoshiya Yamamura

S16-1: Shengying Li
S16-2: Andrew J. DevineS16-3: Xiaoqiang Wang
S16-4: Satoshi Nagao

S17-1: Hajime Mizuno
S17-2: Asami Toshima
S17-3: Yoshihiro Izumi
S17-4: Yuji Nashimoto
S17-5: Siyu Liu
S17-6: Natsuki Makiguchi

S18-1: Yuji Sakurai
S18-2: Hiroshi Arakawa
S18-3: Yoshitane Nozaki
S18-4: Katsuhisa Inoue

S19-1: Shinichi Banba
S19-2: Akiya Jouraku
S19-3: Hirofumi Hirai
S19-4: Mayumi Ishizuka, Shouta Nakayama,
Yoshinori Ikenaka

5演者の場合、8:30開始
Speaker：Poster Display

11:00

Poster Presentation
11:30

3P-XXX
12:00

Poster Display
12:30

13:00

13:30

Luncheon Seminar 8

Luncheon Seminar 9

Electronic laboratory notebook that promotes
collaboration and utilization from accumulationof information

Introduction of 4D-omics for drug discoveryand PK/PD studies

Luncheon Seminar 10
Enhancing Solubility and Achieving Sustained Release of Poorly
Water-Soluble Compounds Utilizing the Novel Pharmaceutical
Excipient SonanosTM (Hyaluronic Acid Nanogel)
Challenges in conducting DMPK studies in Japan and Solutions
which Pharmaron can provide

Luncheon Seminar 11
To The Future of Microscopy Imaging

Speaker: Takayoshi MatsubaraSpeaker: Ryo Nakabayashi

Chair: Takushi Kanazu
Speakers: Takashi Nakai, Masaki Ishigai

Chair: Shintaro Tanaka
Speakers: Syunsuke Yamamoto, Miyu
Nakayama, Toshiyuki Hatano

Sponsored by Revvity Japan Co., Ltd.

Sponsored by Bruker Japan K.K.

Sponsored by Pharmaron Japan, LLC.

Sponsored by Leica Microsystems, K.K.

Plenary lecture 2
14:00

14:30

15:00

15:30

Bile Acid Generating-Cytochrome P450 8B1:
Structure/Function Towards Drug Design
Chair: Kouichi Yoshinari
Speaker: Emily E. Scott

Symposium 20

Symposium 21

Modeling and Systems Pharmacology DIS

ICCP450

Comprehension of the present and future ofsystems modeling in drug discovery -Bridging

Mechanisms and Dynamics of P450

16:30

Chair: Takehiko Tosha
Chair: Yuma Morimoto

Chairs: Chie Emoto, Tsuyoshi Minematsu
S20-2: Amin Rostami-HodjeganS21-1: Alec H. Follmer
S21-2: Michael T. Green
S21-3: Mitsuo Shoji
S21-4: Binju Wang
S21-5: Peter Moody

Chairs: Yoshinobu Nakamaru, Ryoko Sawamura
S20-4: Shinji Yamazaki
17:00

Chairs: Shinichi Kijima, Yuki Iwaki
S20-5: Wangda Zhou
Panel Discussion
Chairs: Koji Chiba, Teruki Hamada

17:30

18:00

18:30

19:00

19:30

Symposium 22

Symposium 23

ICCP450

Educational and Crosscutting DIS

New Horizons in Nuclear Receptor Research:
Novel Molecular Mechanisms and Beyond

Basic course of pharmacokinetics
on cross-disciplinary

JSSX Award Winners'

Chair: Koji Chiba
S20-1: Teruki Hamada

Chairs: Hiroyuki Sayama, Satoshi Nakayama
S20-3: Takashi Yoshikado

New JSSX President's Lecture
Chair: Fumiyoshi Yamashita, Speaker: Yukio Kato

from the traditional model analysis to the latest
research16:00

JSSX Award Ceremony

Presentation
JSSX Award: Tamihide Matsunaga
Young Scientists Award: Hiroto Hatakeyama
Young Scientists Award: Yusuke Masuo
Young Industrial Scientists Award: Katsunori
Sasahara

Chair: Toshiyuki Sakaki
Chair: Masahiko Negishi

Chair: Seigo Sanoh
Chair: Tomomi Furihata

SY22-1: Ryota Shizu
SY22-2-1: Ryota Shizu, Kouichi Yoshinari
SY22-2-2: Hongbing Wang
SY22-3: Grace Guo
SY22-4: Naoki Harada
SY22-5: Taosheng Chen
SY22-6: Toshiyuki SakakiS23-1: Kaoru Kobayashi
S23-2: Kazuya Maeda
S23-3: Takahiro Iwao
S23-4: Shimpei Terasaka
S23-5: Takanobu Matsuzaki

Commercial Exhibition2023 September 29 (Fri.)

9:00

9:30

GRANSHIP (Shizuoka Convention and Arts Center)

Room A

Room B

Room CRoom D

Room E

Room F

Exhibition

1F Medium Hall - Earth

11F Conference Hall - Winds

6F Reception Hall

10F Conference Room 1001-1&2

9F Conference Room 910

1F Main Hall - Ocean

1F Main Hall - Ocean

Symposium 24

Symposium 25

Microphysiological system and iPS DISICCP450

Recent trends in MPS development and its
applications to drug discovery ―What is

P450 Across Plant, Insect,and Microbial Systems

Symposium 26

10:00

10:30

S24-1: Shinji Iwasaki
S24-2: Wataru Kishimoto
S24-3: Seiichi IshidaS24-4: Takeshi SakuraS24-5: Yuki Yamamoto
S24-6: Takashi Osaka

Chair: Hirofumi Ichinose
Chair: Masaharu Mizutani
Chair: Toshiyuki Ohnishi
S25-1: Max J. Cryle
S25-2: Birger Lindberg Møller
S25-3: Kentaro Itokawa
S25-4: Harro J. Bouwmeester
S25-5: Hirofumi Ichinose

Symposium 28

Drug Efficacy and Safety DIS

ICCP450

Lymphatic and glymphatic systemfrom the perspective of drug development
and clinical therapeutics

The power of metalloenzymes:
Insights from model complexes and beyondChair: Kouichi Yoshinari
Chair: Kenji Mizuguchi

Chair: Masanori Tachikawa
Chair: Yuki Kishino

Chair: Hiroshi Fujii
Chair: Wonwoo Nam

S26-1: Kenji Mizuguchi
S26-2: Chunzhi Ai
S26-3: Koichi Handa
S26-4: Yui Migura

S27-1: Masanori Tachikawa
S27-2: Tetsuya Kodama
S27-3: Kaoru Yamada
S27-4: Makoto Hirasawa
S27-5: Syunsuke Yamamoto

S28-1: Hiroshi Fujii
S28-2: Wonwoo Nam
S28-3: Tsunehiko Higuchi
S28-4: David P. Goldberg

ADMET and AI: What we can do now
and what we need to do in the future.

happening towards industrial implementation andregulatory acceptance in Japan? ―Chair: Hiroyuki Mizuguchi
Chair: Hideki Hirabayashi

Symposium 27

11:00

Plenary lecture ３
11:30

12:00

Biotransformation of Non-Native Substrates
by Cytochrome P450s Utilizing Their
Substrate Misrecognition Triggered by Decoy
Molecules
Chair: Shingo Nagano
Speaker: Osami Shoji

12:30

Luncheon Seminar 12
Pharmacokinetic Evaluation of New Modalities

13:00

Chair: Akihito Shimoi
Speaker: Yasuharu Nakanishi
Sponsored by Shin Nippon Biomedical Laboratories,
Ltd.

13:30

Symposium 29
14:00

Symposium 30

Symposium 31

Symposium 32

Selected Oral Presentation 2

New modality DIS

ICCP450

IQ Consortium Symposium

Rising to the challenge: First-in-human dose
determination of new therapeutic modalities

Oxygenase in natural product biosynthesis

Advance Technologies in DMPK Researchfor Drug Development

Drug Metabolism andDrug Induced Toxicity DIS
Application of biomarkers for prediction ofdrug metabolism and toxicity, and diagnosis

Chair: Syunsuke Yamamoto
Chair: Makiya Nishikawa

Chair: Osami Shoji
Chair: Takahiro Mori

Chair: Akihiro Hisaka
Chair: Takeshi Tajima

Chair: Seigo SanohChair: Toru Usui

Chair: Jonathan Worrall
Chair: Shinya Ariyasu

S29-1: Kazushige Maki
S29-2: Akihiko Goto
S29-3: Miho Nagayasu
S29-4: Tsuyoshi Karibe

S30-1: Yudai Matsuda
S30-2: Takahiro Mori
S30-3: Shunji Takahashi
S30-4: Takehiko Tosha

S31-1: Natalie A. Hosea
S31-2: Surinder Kaur
S31-3: Prashant Desai
S31-4-1: Ryuta Saito
S31-4-2: Kenichi Umehara
S31-5: Tycho Heimbach

S32-1: Ryousuke Kobayashi
S32-2: Sumio Ohtsuki
S32-3: Kosuke Saito
S32-4: Koretsugu Ogata
S32-5: Takafumi Akabane

SOP2-1: Peter J. Roy
SOP2-2: Svetlana Gorina
SOP2-3: Yasuhiro Tateishi
SOP2-4: Erisa Harada
SOP2-5: Alix Charles Harlington

14:30

15:00

Co-sponsored: "Forecasting Biosynthesis" inthe JSPS Grant-in-Aid for Transformative
Research Areas (A)

15:30

16:00

16:30

17:00

17:30

18:00

18:30

19:00

19:30

Awards ceremony and Closing

Poster Display

Commercial Exhibition