The original disclosure in Japanese was released on May 12, 2022 at 15:00 (GMT +8)
Note: This document has been translated from the Japanese original for reference purposes only. In the event ofany discrepancy between this translated document and the Japanese original, the original shall prevail.

May 12, 2022
CompanyHeadquarters
Representative
Contact
Telephone
WebsiteTakara Bio Inc. (Prime Market TSE, code: 4974)
Nojihigashi 7-4-38, Kusatsu, Shiga, Japan
Koichi Nakao, President & CEO
Takuya Kakemi, Executive Officer, Head ofCorporate Management Division(+81)77-565-6970
https://www.takara-bio.co.jp/

Notice of Dividends of Surplus

Takara Bio Inc. announced the declaration of the following dividend of retained earnings with a record date ofMarch 31, 2022 at the Board of Directors meeting on May 12, 2022. This matter will be resolved at the Annual
General Meeting of Shareholders to be held on June 24, 2022.

1. Details of dividends

Determined amount

Most recent dividend
forecast (Announced onFebruary. 10, 2022)

Results for the previous
fiscal year (Year ended
March 31, 2021)

Record date

March 31, 2022

March 31, 2022

March 31, 2021Dividend per share¥33.00¥30.00¥16.00Total dividend
amount¥3,973 million-¥1,926 million

Effective dateJune 27, 2022-

June 25, 2021

Dividend source

Retained earnings-

Retained earnings

2. Reason
We consider returning profits to shareholders to be an important management issue, while paying attention toenhancing internal reserves in order to actively implement R&D activities in both Bioindustry business andGene therapy business. Our basic policy is to return profits to shareholders based on a comprehensive
consideration of our operating results and financial position. Specifically, the Company's policy is to pay
dividends from retained earnings of approximately 20% of the estimated net income, which is calculated
without taking into account extraordinary gains and losses in the consolidated financial statements.

The original disclosure in Japanese was released on May 12, 2022 at 15:00 (GMT +8)
Based on this policy, we revised its fiscal year-end dividend for the year ended March 31, 2022 to ¥33.00,
an increase of ¥3.00 from the previous forecast of ¥30.00 per share announced on February 10, 2022.

(Reference)

Record Date
Actual results
Results for the previous fiscal year
(Year ended March 31, 2021)

ndEnd of 2 quarter¥0.00

Dividends per share
Year-end¥33.00Total¥33.00¥0.00¥16.00¥16.00Forward-Looking Statements
Statements contained in these materials with respect to the Company’s current plans, forecasts, strategies and beliefs thatare not historical facts are forward-looking statements about the further performance of the Company and its consolidated
subsidiaries. These statements are based on management’s assumptions and beliefs in light of information currently
available to it, but are based on a number of assumptions and beliefs derived from information that contains significant
risks and uncertainties. Actual results may differ materially from these forecasts due to various factors. Factors that could
influence actual results include, but are not limited to, economic conditions, especially trends in consumer spending, as
well as exchange rate fluctuations, changes in laws and government systems, pressure from competitors’ prices and productstrategies, declines in selling power of the Company’s existing and new products, disruptions to production, violations ofour intellectual property rights, rapid advances in technology, and unfavorable verdicts in major litigation.