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Category:American record producers Category:American male composers Category:21st-century American composers
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Category:21st-century male singersTargeting microRNA miR-17-92 to overcome resistance to HER2-targeted therapies. The
microRNA miR-17-92 is aberrantly overexpressed in various types of cancers, including breast cancer. In particular, miR-17-92
targets the PTEN tumor suppressor and the insulin receptor and, hence, has been proposed to mediate resistance to targetedtherapies. We analyzed whether miR-17-92 modulates sensitivity of HER2+ breast cancer cells to HER2-targeting therapies.
MiR-17-92 expression levels were determined in cell lines that had been engineered to overexpress HER2 and that weresensitive or resistant to lapatinib and trastuzumab. The functional

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