Strengthen ligaments
and tendons• Increase of tendon strengthand flexibility• Faster return-to-training• Clinically shown to reduce risk of injury

Collagen –The Body Protein!

Osteoporosis

Normal bonematrix

Collagen is a major component of the human body. About
30 % of our total body protein is collagen. Collagen is crucial
for mobile joints, stable bones, healthy muscles, strong
ligaments and tendons, smooth skin, glossy hair and healthy
finger nails. It is one of the primary structural proteinsof connective tissues and also abundant in blood vessels,intervertebral discs, the blood-brain barrier, the cornea,dentin and the intestinal wall – a vital component of ourwhole body.

Bioactive Collagen Peptides®
stimulate collagen metabolism
GELITA Bioactive Collagen Peptides ® (BCP) are a composition of different specific peptides optimized forspecific physiological benefits. The peptides are derived
from a highly controlled production process of collagen
which is determined by hydrolysation conditions.
As a result, GELITA Bioactive Collagen Peptides ® differ inphysiological functionality. They are optimized to maximizestimulation of the human cell types involved in collagenbiosynthesis.

Native collagen is split

The effect of collagen peptides on increased extracellularmatrix synthesis is based on two mechanisms:1)	Supply of typical collagen amino acids as valuablebuilding blocks2)	Stimulate cell synthesis
Bioactive Collagen Peptides®
Skin HealthFibroblasts

VERISOL®

Joint HealthChondrocytes

FORTIGEL®

Bone Health

Osteoblasts/Osteoclasts

FORTIBONE®

Body Toning

Muscle cells

BODYBALANCE®

Ligaments/Tendons

Ligamentocytes/Tendocytes

TENDOFORTE®

Extracellular matrix
CatabolismAnabolism

Extracellular matrix
Thermal/Chemical
Hydrolysis

Specific andcontrolled
enzymatichydrolysis
Bones

Native collagen in
raw material[2]

Bioactive Collagen
Peptides®

Proteases

CollagenProteoglycan
etc.

Connective tissue cells

Tendons and ligaments
determine mobility
Strong tendons and ligaments are crucial for lifelong wellness
and physical activity. Ligaments bind bones together andtendons bind muscle to bone. Made of collagen, they are
the connecting elements of the body, crucial for movement
control, stability, and better mobility.
Especially for active people, soft-tissue injuries, those affecting
muscles, tendons and ligaments, are extremely common at alllevels of sport. Whether it is running, climbing, tennis, golf
or soccer, most injuries result from the overuse of tendons.
These are very common because strength, power, and speed
are dependent on rigid tendons. However, harder tendons may
be better for performance but they are also more injury prone.
High performing tendons and ligaments combine strength andflexibility. Collagen fibres give them the right elasticity for
optimal function and performance. Tendon injuries are characterized by collagen fibre degeneration and are slow to recoverand disrupt training with a number of personal, competitive andfinancial consequences to the high per­formance athlete or theexercise enthusiast.
MuscleTENDOFORTE® strengthens
ligaments and tendonsTENDOFORTE ®, specific Bioactive Collagen Peptides ® fromGELITA, is designed to increase health and quality of ligaments
and tendons. Pre-clinical and clinical trials show the positiveeffects of TENDOFORTE®, especially when combined withphysical activity. The risk of injury decreases considerably,
whilst flexibility improves. TENDOFORTE ® significantly
strengthens tendons and ligaments and more studies areunderway.

BoneDeltoidligament

AchillestendonTendon

Tendon sheaths[3]

TENDOFORTE® is an effective
nutritional intervention forstrong tendons and ligaments

Significant expression of extracellular matrix
molecules with Bioactive Collagen Peptides®.
2.5*p<0.05n>12*

The strength of tendons and ligaments depends on an intact
composition of the extracellular matrix collagens, proteoglycans and elastic fibers. TENDOFORTE ® is a Bioactive Collagen
Peptide ®, optimized to stimulate the biosynthesis of new
extracellular matrix molecules for healthy tendons andligaments.

TENDOFORTE® benefits thebiosynthesis of matrix moleculesof tendons and ligaments
A first experiment in-vitro observed that Fibroblasts,
obtained from human ligaments and Achilles tendons,
were able to produce significantly more tissue matrix(1.2 to 2.4-fold) when directly exposed to the Bioactive
Collagen Peptides ® found in TENDOFORTE ®.
The RNA expression of collagen significantly increased,
and the synthesis of elastin - the most prominent componentof the ligament matrix - increased by approximately 50%.
The break-down of tissue was also reduced.

*2x-fold of control

Strong tendons and ligaments contribute to the foundationof high physical performance and fast return-to-training
in athletes. They are also the prerequisite for the fluid andflowing motion required in isometric, high flexibility exercises,
such as yoga and Pilates.

1.5

10.50Collagen Type I

DecorinProteoglycan

Schunck and Oesser, 2013.

TENDOFORTE® improves
extension properties of thefinger joints
In one of the first clinical trials to look at a nutritional inter­
vention for connective tissue weaknesses, the oral ingestion of
specific collagen peptides were shown to improve the extension
properties of the finger joints, due to firmer ligaments.

Proven improvements in mechanical stabilityof finger ligaments

This was the first study to suggest a role for Bioactive
Collagen Peptides ® in reducing the risk of injuries andrupture of ligaments and tendons.

Weh and Petau, 2001.

[4]

Versicancontrol

Recent study shows theefficacy of TENDOFORTE®
A study of the Australian Institute of Sport (AIS) examined thebenefits of TENDOFORTE® supplementation over a period of
6 months (cross-over design). The participants were 20 subjects
with long-term symptoms of chronic Achilles tendinopathy,
not responding to any traditional therapies and being unable
to train. Within 3 months, 12 out of 20 participants were able
to return to running after starting a therapy with daily intakeof 5 g TENDOFORTE® in combination with a highly specialized
exercise program. Furthermore, the effect is long-term. The
group starting with TENDOFORTE® in the cross-over design still
had beneficial effects after the 3 months wash-out phase.
South African Journal of Sports Medicine, 2017.

% of Participants Returned-to-training

AIS Study – participants starting with TENDOFORTE®
supplementation returned to running, faster

Improving ankle stability

8060

40

200Start

3 months

6 months

Strong tendons effectively transform muscle
work into movement

Reduced injuries due toimproved ankle stability
In 2017, a randomized controlled study examined the effect ofTENDOFORTE® on 60 men and women with ankle point instability
over a period of 6 months. The daily intake of 5 g TENDOFORTE®
showed a significant improvement of ankle stability during daily
activity and during sports as well as significantly less injuries.
Journal of Sport Science and Medicine, 2018.

[5]

TENDOFORTE® for Connective Strength
Flyer_TENDOFORTE_eng (6p)_04-2018_srg

TENDOFORTE® provides
connective strength
TENDOFORTE® is optimized to increase health and qualityof ligaments and tendons. The specific Bioactive Collagen
Peptides ® from GELITA address high performance athletes
and exercise enthusiasts as well as everybody having issuesrelated to ligaments and tendons, such as CAI (chronic ankleinstability), which often manifests after ankle sprains, oneof the most widely spread sport injuries.

TechnologicalpropertiesTENDOFORTE ® is a natural protein of neutral odor and tastethat can be implemented into a number of applications. It
provides excellent solubility and can be easily incorporated
in any delivery format.

TENDOFORTE®
promotes• clean label• high digestibility• no allergens• scientific evidence

Make innovative product ideas a reality!
TENDOFORTE® can be used in a variety of supplement formats such as bars,gels, sachets, powder jars or shakes, gummies and shots.

Gelita excludes any warranty and/or liability for any and all claims arising from or in relation with statements made in thisbrochure and/or the positioning of TENDOFORTE®, including but not limited to claims based on misleading advertising and/or
breach of relevant German and EU legislation. The positioning as well as the packaging, labelling and advertising of the client’s
products with TENDOFORTE® falls solely within the responsibility of the client.

GELITA AG · Uferstr. 7 · 69412 Eberbach · Germany · www.gelita.com