Curriculum Vitae

Adrian W Moore PhD

Team Leader
Laboratory for Neurodiversity
RIKEN Center for Brain Science (CBS)2-1 Hirosawa, Wako-shi, Saitama
351-0198, Japanadrian.moore@riken.jp
Tel: 81-48-467-7278

September 2022

ORCID ID:
0000-0002-8242-301X
ResearcherID: AAN-5656-2021
Professional Experience
2018–
Team Leader, Laboratory for Neurodiversity, RIKEN Center for Brain Science, JPN
2012–2018
Team Leader, Laboratory for Genetic Control of Neuronal Architecture, RIKEN Brain
Science Institute, JPN
2004–2012
Unit Leader, RIKEN Brain Science Institute, JPN
1999–2003
Postdoctoral Fellow, Laboratory of Dr Yuh Nung Jan,
University of California, San Francisco, USA
1998
Postdoctoral Fellow, Laboratory of Dr Nicholas Hastie,
MRC Human Genetics Unit, Edinburgh, UK
1993–1997
Graduate Student, Laboratory of Dr Nicholas Hastie,
MRC Human Genetics Unit, Edinburgh, UK
1992
Research Assistant, Laboratory of Kim Nasmyth,
Institute of Molecular Pathology, Vienna, AUT
1990
Research Assistant, Type II Diabetes Research Team,
Glaxo Group Research, London, UK
Co-appointments
2022–
Visiting Associate Professor, Institute for Frontier Life and Medical Sciences; Kyoto
University, JP
2017–
Visiting Professor, Institute of Translational Medicine, University of Liverpool, UK2013–2018
Visiting Professor, School of Health Sciences, Malaysia University of Science, MYS
Education
1993–1997
1994
1990–1993

PhD, Biological Sciences, University of Edinburgh
MA, University of Cambridge
BA, Genetics, University of Cambridge, 1st class honorsAwards
2020
2016
2015
2014
2011–2012
1999–2002
1996

Naito Foundation Award
Takeda Science Foundation Award
Novartis Award
Mochida Memorial Foundation Award
RIKEN Presidents Fund Award
Wellcome Trust International Prize Traveling Research Fellowship
Promega Young Geneticist of the Year (Scotland); awarded by the Genetics Society

Selected Professional Activities
Editorial: Editorial Board, Fly. Associate Editor, Frontiers in Cellular Neuroscience, section CellularNeurophysiology. Ad Hoc Editor PLoS Genetics
ad hoc Advisor: Medical Research Council, UK.
British Council and UK Embassy in Japan Innovation Section, JPN
Meeting Organization
Meeting Chair: 2024, Asia Pacific Drosophila Neurobiology, Tokyo, JPN
Chair: 2022, RIKEN CBS Summer Course 2022: Architectures of the Brain
Meeting Chair: 2014, Epigenetics in the Brain: to the Single Cell Level, London, UK.
Meeting Chair: 2103, Neural Epigenetics: From Mechanisms to Disease, Tokyo, JPN
Scientific Committee: 2019, Asia Pacific Drosophila Neurobiology, Taipei, TWN
Scientific Committee: 2016, Asia Pacific Drosophila Neurobiology, Wuhan, CHN

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Symposium Organizer: 2020, 43rd annual meeting of the Molecular Biology Society of Japan, JPN(Decoding and Engineering Cell Shape)
Symposium Organizer: 2018, 17th European Drosophila Neurobiology Meeting, Krakow, POL(Cytoskeleton to Plasticity)
Publications
Suzuki T, Tatsukawa T, Sudo G, Delandre C, Pai YJ, Miyamoto H, Raveau M, Shimohata A, Ohmori I,
Hamano S, Haginoya K, Uematsu M, Takahashi Y, Morimoto M, Fujimoto S, Osaka H, Oguni H, OsawaM, Ishii A, Hirose S, Kaneko S, Inoue Y, Moore AW, Yamakawa K (2022) CUX2 deficiency causes
facilitation of excitatory synaptic transmission onto hippocampus and increased seizure
susceptibility to kainite Scientific Reports 12:e6505.
Tann JY, Wilkes OR, Xu F, Yoong LF, Skibbe H, Moore AW (2022) Study of dendrite differentiation
using Drosophila dendritic arborization neurons. Drosophila Neurobiology: A Laboratory Manual(2nd edition) in press.
Pai YJ, Moore AW (2021) Transcription factor encoding of neuron subtype: strategies that specify
arbor pattern. Curr. Opin. Neurobiol. 69: 149-158
Yoong LF, Lim HK, Tran H, Lackner S, Zheng Z, Hong P, Moore AW (2020) Atypical myosin tunes
dendrite arbor subdivision. Neuron 106:452-467
Rives-Quinto N, Komori N, Ostgaard CM, Janssens DH, Kondo S, Dai Q, Moore AW, Lee CY (2020)
Sequential activation of transcriptional repressors promotes progenitor commitment by silencing
stem cell identity genes Elife 9:e56187
Liang X, Kokes M, Fetter RD, Sallee MD, Moore AW, Feldman JL, Shen K (2020) Growth conelocalized microtubule organizing center establishes microtubule orientation in dendrites. Elife
9:e56547
Wilkes OR, Moore AW (2020) Distinct Microtubule Organizing Center Mechanisms Combine toGenerate Neuron Polarity and Arbor Complexity. Front. Cell. Neurosci. 14:e398
Urun FR, Moore AW (2020) Visualizing Cell Cycle Phase Organization and Control During Neural
Lineage Elaboration. Cells 9:e2112
Tann JY, Moore AW (2019) MTOC Organization and Competition During Neuron Differentiation.
Results. Probl. Cell. Differ. 67:337-357
Yoong LF, Pai YJ, Moore AW (2019) Stages and transitions in dendrite arbor differentiation.
Neurosci. Res. 138:70-78.
Pai YJ, Moore AW (2018) Dendritic actin delivery service. J. Cell. Biol. 217:3325-3326
Delandre C, Amikura R, Moore AW (2016) Microtubule Nucleation and Organization in Dendrites.
Cell Cycle 15:1685-92.
Klebanow LR, Peshel EC, Schuster AT, De K, Sarvepalli K, Lemieux ME, Lenoir JJ, Moore AW,
McDonald JA, and Longworth MS (2016) Drosophila Condensin II subunit, Chromosome AssociatedProtein-D3, regulates cell fate determination through non-cell autonomous signaling. Development
143:2791-802.
Yalgin C, Ebrahimi S, Delandre C, Yoong LF, Akimoto S, Tran H, Amikura R, Spokony R, Torben-Nielsen
B, White KP, Moore AW (2015) Centrosomin represses dendrite branching by orienting microtubule
nucleation. Nat. Neurosci. 18:1437-45.
Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M, Themistocleous AC, Strom TM, SamaraC, Moore AW, Cho LT, Young GT, Weiss C, Schabhüttl M, Stucka R, Schmid AB, Parman Y, GraulNeumann L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner M, Valente EM,Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C, Wieland T, Stafford F, Reimann F, von Au K,Finke C, Willems PJ, Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G, McAleer MA, Cilio
MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB, Windhager R, Weis J, Bergmann C, Rautenstrauss
B, Baets J, De Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T, Bennett DL, Woods CG,Senderek J (2015) Transcriptional regulator PRDM12 is essential for human pain perception. Nat.
Genet. 7:803-8.
Taniguchi H, Moore AW (2014) Chromatin regulators in neurodevelopment and disease: Analysis offly neural circuits provides insights. Bioessays 36:872-83.
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri
E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG(2014) Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital
heart defects. PLoS One 9:e89397.

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Karim MR, Endo K, Moore AW, Taniguchi H (2014) Whole mount immunolabeling of olfactory
receptor neurons in the Drosophila antenna. J Vis Exp (87).
Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EKY, Moore AW, Chen Y, Cheng C, and Ernst P(2013) MLL-dependent network sustains hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 110:12000-5.
Endo K, Karim MR, Taniguchi H, Krejci A, Kinameri E, Siebert M, Ito K, Bray S, Moore AW (2012)
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat. Neurosci.
15:224-33.
Hohenauer T, Moore AW (2012) The Prdm family: expanding roles in stem cells and development.
Development. 139:2267-82.
Nagel J, Delandre C, Zhang Y, Förstner F, Moore AW, Tavosanis G (2012) Fascin controls neuronalclass-specific dendrite arbor morphology. Development. 139:2999-3009.
Karim MR, Moore AW (2011) Convergent local identity and topographic projection of sensory
neurons. J. Neurosci. 31:17017-27.
Yalgin C, Karim MR, Moore AW (2011) Immunohistological labeling of microtubules in sensory
neuron dendrites, tracheae, and muscles in the Drosophila larva body wall. J Vis Exp. (57) :3662
Karim MR, Moore AW (2011) Morphological analysis of Drosophila larval peripheral sensory neuron
dendrites and axons using genetic mosaics. J. Vis. Exp. (57) e3111
Nishimura Y, Yalgin C, Akimoto S, Doumanis J, Sasajima R, Nukina N, Miyakawa H, Moore AW,
Morimoto T (2010) Selection of behaviors and segmental coordination during larval locomotion is
disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model.
J. Neurogenet. 24:194-206.
Doumanis J, Wada K, Kino Y, Moore AW, Nukina N (2009) RNAi screening in Drosophila cells
identifies new modifiers of mutant huntingtin aggregation. PLoS One. 4:e7275.
Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T, Moore AW (2008) Prdm protooncogene transcription factor family expression and interaction with the Notch-Hes pathway inmouse neurogenesis. PLoS One. 3:e3859.
Moore AW (2008) Intrinsic mechanisms to define neuron class-specific dendrite arbor morphology.
Cell. Adh. Migr. 2:81-82.
Jinushi-Nakao S, Arvind R, Amikura R, Kinameri E, Liu AW, Moore AW (2007) Knot/Collier and cut
control different aspects of dendrite cytoskeleton and synergize to define final arbor shape. Neuron.
56:963-978.
Kuzin A, Brody T, Moore AW, Odenwald WF (2005) Nerfin-1 is required for early axon guidance
decisions in the developing Drosophila CNS. Dev. Biol. 277:347-365.
Moore AW, Roegiers F, Jan LY, Jan YN (2004) Conversion of neurons and glia to external-cell fates inthe external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-typerespecification. Genes. Dev. 18:623-628.
King-Underwood L, Little S, Baker M, Clutterbuck R, Delassus S, Enver T, Lebozer C, Min T, Moore A,Schedl A, Pritchard-Jones K (2005) Wt1 is not essential for hematopoiesis in the mouse. Leuk. Res.
29:803-12.
Grueber WB, Ye B, Moore AW, Jan LY, Jan YN (2003) Dendrites of distinct classes of Drosophila
sensory neurons show different capacities for homotypic repulsion. Curr. Biol. 13:618-626.
Moore AW, Jan LY, Jan YN (2002) hamlet, a binary genetic switch between single- and multipledendrite neuron morphology. Science. 297:1355-1358.
Moore AW, Barbel S, Jan LY, Jan YN (2000) A genomewide survey of basic helix-loop-helix factors inDrosophila. Proc. Natl. Acad. Sci. U.S.A. 97:10436-10441.
Moore AW, McInnes L, Kreidberg J, Hastie ND, Schedl A (1999) YAC complementation shows arequirement for Wt1 in the development of epicardium, adrenal gland and throughout
nephrogenesis. Development. 126:1845-1857.
Davies R, Moore A, Schedl A, Bratt E, Miyahawa K, Ladomery M, Miles C, Menke A, van Heyningen V,Hastie N (1999) Multiple roles for the Wilms' tumor suppressor, WT1. Cancer Res. 59:1747s-1750s.
Moore AW, Schedl A, McInnes L, Doyle M, Hecksher-Sorensen J, Hastie ND (1998) YAC transgenicanalysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing
diaphragm and limb. Mech. Dev. 79:169-184.
Miyagawa K, Kent J, Moore A, Charlieu JP, Little MH, Williamson KA, Kelsey A, Brown KW, Hassam S,Briner J, Hayashi Y, Hirai H, Yazaki Y, van Heyningen V, Hastie ND (1998) Loss of WT1 function leadsto ectopic myogenesis in Wilms' tumour. Nat Genet. 18:15-17.

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Moll T, Schwob E, Koch C, Moore A, Auer H, Nasmyth K (1993) Transcription factors important forstarting the cell cycle in yeast. Philos. Trans. R. Soc. Lond. B Biol. Sci. 340:351-360.
Selected Presentations (since 2016)2022 Singapore Developmental Biology Club, NUS, SGP
2020 5th Asia Pacific Drosophila Research Conference, Pune, IND
2019 Department of Molecular Genetics and Cell Biology, University of Chicago, USA
Life Sciences Institute, University of Michigan, USA
Neuroscience, School of Medicine, Case Western University, USAJan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Baylor
College of Medicine, USA
Neurobiology & Anatomy, School of Medicine, University of Utah, USANEURO2019, Niigata, JPN
School of Medicine, Nanyang Technological University, SGP
Cell Biology, Temasek Life Sciences Laboratory, SGP
2018 Department of Zoology, University of Cambridge, UK
MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK
CRTD Technische Universität Dresden, DEU
Mechanobiology Institute, National University of Singapore, SGP
Duke Neuroscience, National University of Singapore, SGP
Cell Biology, Temasek Life Sciences Laboratory, SGP
The Center for Advanced Biomedical Sciences TWIns, Waseda University, Tokyo, JP
17th European Drosophila Neurobiology Conference, Krakow, POL
EMBO Workshop - Neural Development, Taipei, TWN
2017 RIKEN QBIC, Osaka, JPN
National Institute of Genetics, Mishima, JPN
Single Cell Science Symposium: Technology Meets Biology, Yokohama, JPN
Department of Neuroscience, Yale School of Medicine, USA
Developmental Biology Program, Sloan Kettering Institute, USA
Department of Biology, New York University, USA
Department of Neurology, University of Massachusetts Medical School, USA
Feinberg School of Medicine, Northwestern University, USA
Department of Biosciences and Nutrition, Karolinska Institute, SWE
SciLifeLab, SWEFaculty of Medicine and Health Sciences, University of Linkoping, SWE
Cell Biology, Temasek Life Sciences Laboratory, SGP
Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Baylor
College of Medicine, USA
EMBO Conference on Cell Biology of the Neuron: Polarity, Plasticity and Regeneration,
Heralikon, GRC
IUBMB Focused Meeting on Emerging Concepts of the Neuronal Cytoskeleton, PuertoMontt, CHL
1st Asia Pacific Drosophila Neurobiology Conference, Wuhan, CHN
2016 Neuroscience Program, University of California, San Francisco, USA
Department of Pathology, Stanford University School of Medicine, USA
Molecular, Cellular, Developmental Biology, University of California Santa Barbara, USA
Neurobiology Section, Dornsife College, Biological Sciences, University of Southern
California, USA
Department of Molecular Cell and Developmental Biology, University of California Los
Angeles, USA
Digital Representation of Neuronal Morphologies and Tissue, Workshop, OIST, JPN
Institute for Frontier Science Initiative, Kanazawa University, JPN

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