2ফা঩ূপள୅੶୛൥ൡ

ਸ਼৚&63+25ফভَ42/௬੼भਈ৐଍ ‫ع‬ফभஷॉନॉध০৏भன஦‫ُع‬

4$/< 4XDOLW\$GMXVWHG/LIH<HDUz ৽ৎ஍৷கभශ଍৲એ஋ েோফਯ॑42/ ஍৷க द੎ातऐ4$/<भੰෲपঢ়ॎॊଁੑ৓ऩਖ਻ຠ⏝್1ূ਎প৾প৾੹ ୢ৾௺ଢ଼஢ఐ௏೨ఐ৾‫่؞‬૧৾௧వ ে੟ଁੑ৾ী৙༖ਉ೨೗᏶඲䛺೺ᗣ᭤⥺໬㠃✚䠙QALY0েோফਯध42/॑৊ৎपઅൟ

⏕Ꮡᖺᩘ

345&7ॹ‫॑ॱش‬৷ःञ4$/<भଁੑੰෲz ষअधऌ ಏ෫ଢ଼஢भ௏೨ঢ়৴42/॔क़ॺढ़঒धखथ

¾ ୻ਤষ᷈ቅदभ*(67૥ୡ 8HQRHWDO-&2 ા৷஍ટীෲभ஍ટधखथ

¾ ୻ৣ⍴ንᯂदभ9HQ86 ,,૥ୡ 6RDUHV HWDO%0-
¾ হ୻धखथງஂz […], median QALY were 0.401 in thegemcitabine group, […]z The QALY value in the GS group was
significantly better than that in thegemcitabine group (P<.001).

z ম঩भਵ਻ ૥ୡ਋৑भીവऩन॑৶૓पखञઊठજॉ ঋ‫ش‬५ছॖথ஍৷கदभ৹ତ56হ୻‫ৣ؟‬⍴ንᯂपৌघॊঐ०ॵॺ௜১ क़४ད भા৷஍ટীෲ

॔क़ॺছॖথz হ୻ງஂ 9HQ86 ,,૥ୡॹ‫॑ॱش‬৷ःञા৷஍ટীෲ ଁੑੰෲभ੶ൗz ଁੑ৓ୖ਻ ઊठજॉॹ‫ॱش‬ध4$/<भଁੑੰෲ ঋ‫ش‬५ছॖথ஍৷கदभ৹ତz হ୻दभ੥ટधऽधी7হ୻‫ৣ؟‬⍴ንᯂपৌघॊঐ०ॵॺ௜১ क़४ད भા৷஍ટীෲ8হ୻दभଁੑੰෲभ੶ൗ

z 9HQ86 ,,ছথॲ঒৲૥ୡ ঐ०ॵॺ௜১ ੡ ୯඄਋৑‫؟‬ਈপऊাYVঁॖॻট।ঝ ੡¾ ીೕपఃஈऔोञ೩঻म‫ع‬ऊাभ୯඄਋৑
¾ ‫ع‬ऊাभँःटप୯඄ીവऋ৅ে
¾ ଈಝमऺऻऩख ஍৷கभ೾৒

Dumville et al. BMJ 2009.
Soares et al. BMJ 2009.

¾ (4'द‫ؚؚؚؚ‬ऊা৯z ऊাऽदभ4$/<॑ଁੑੰෲ ા৷஍ટীෲभ஍ટधखथz We used inverse probability weighting toestimate the mean […] QALYs, accounting forthe censored nature of these data.
z The weights were evaluated as the inverse ofKaplan Meier estimator of censoring probability.
z For QALYs […], we partitioned the study time
horizon in homogenous subintervals (quarterlyintervals) […]z Linear regression was used […]. We included
baseline EQ-5D scores as a covariate in theestimation of QALYs.

9

๕஑৓ऩ5&7भॹ‫ॱش‬ଡୗ

104$/<ੰෲपउऐॊ୯඄ીവधઊठજॉz ଈಝ৐ऽञमঢ়ੱभँॊৎਡ৐प୯඄ऋીവघॊ6䛛᭶䛾 …
ຠ⏝್

ᝈ⪅ID

⩌

ほᐹ⏕Ꮡᖺᩘ

Ṛஸ
䛒䜚

0䛛᭶䛾
ຠ⏝್

3䛛᭶䛾
ຠ⏝್

HOR-001

10.4

YES

0.8

0.7

HOR-002

21.2

YES

0.7

0.8

0.4

…

HOR-003

20.6

YES

0.8

Ḟ

0.7

…

HOR-004

11.5NO

0.90.81.0…

HOR-005

21.1

NO

0.7

0.7

0.9…

HOR-006

12.3

NO

0.7

0.80.4…

HOR-007

10.3

YES

0.50.6Ṛஸᚋ…

䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉䞉Ṛஸᚋ

धઌभ4$/<मਂ৥…

ຠ⏝್z ઌभেோফਯऋ୯඄ીവৎਡ㏣㊧⤊஢भফਯेॉশःऒधमॎऊॊ

1 েோফਯभઊठજॉz ઌभ4$/<ऋ୯඄ીവৎਡऽ

दभ4$/<ेॉপऌःऒधम
ॎऊॊ᭤⥺໬㠃✚䠙ᡴ䛱ษ䜚QALYz ණ‫௴ؚ‬௄েோফਯ‫ؚ‬ଈಝથ૮‫৽ؚ‬ৎ஍৷கz ऒभॹ‫ॱش‬ऊै೩঻ओधप4$/<॑ੑ઴खथ

 4$/<भઊठજॉ

0ණ৑ૻຎ॑खञःᡴ䛱ษ䜚ᚋ䛾ຠ⏝್䛿0௨ୖ䛸௬ᐃ

⏕Ꮡᖺᩘ

1112๕஑৓ऩॹ‫ॱش‬भেோফਯप.DSODQ0HLHU১॑ి৷ઊठજॉॹ‫ॱش‬भଁੑੰෲz েோৎ৑ੰෲधखथ৅னz ୯඄॑ਢऐञधऌभઌभ㻝㻚㻜z ঽேऩૢ৷ েோৎ৑ੰෲু১दઊठજॉ4$/<॑ੰෲ¾ .DSODQ0HLHU১ऩन॑ి৷

"඲⏕Ꮡ๭ྜ .DSODQ0HLHU১‫ؚ‬টॢছথॡਫ਼৒‫&ؚ‬R[৚ష‫ؼؚ‬"েோফਯऋॎऊढञधघॊ㻜㻚㻤 .DSODQ0HLHUශ଍मઌभ

㻜㻚㻢,,,, ,,,,,,, ,,, ,,, ,,,,, ,, ,,,,, ,, ,,,, ,,,,,,, , ,, ,,,, , ,,,, ,,,,,,, ,, , ,,,,, ,,,,,,,,, , , , ,,, ,, ,,㻷㼍㼜㼘㼍㼚㻙㻹㼑㼕㼑㼞᭤⥺┿䛾⏕Ꮡᖺᩘ䛾ศᕸ㻜㻚㻜ి৷मඦ੎प

,, ,,, ,㻜㻚㻠㻜㻚㻞z 4$/<भଁੑੰෲषभ.DSODQ0HLHU১ऩनभেோශ଍॑ેী੺๚,,, ,,,,,㻜㻚㻜㻜㻚㻡㻝㻚㻜㻝㻚㻡㻞㻚㻜㻞㻚㻡㻟㻚㻜⏕Ꮡᖺᩘ1314๕஑৓ऩॹ‫ॱش‬भ4$/<प.DSODQ0HLHU১॑ి৷㻽㻭㻸㼅䛾⏕Ꮡ๭ྜ㻝㻚㻜,,,,,,㻜㻚㻤,z ੔ऺनभ๕஑৓ऩॹ‫ॱش‬ऊैয॑௷ऌলघ㻽㻭㻸㼅䛾㻷㼍㼜㼘㼍㼚㻙㻹㼑㼕㼑㼞᭤⥺┿䛾㻽㻭㻸㼅䛾ศᕸ,,,,,,,

㻜㻚㻢ල౐ऩ୻दઅइथाॊ,,,,,,, ,㻜㻚㻠 ஍৷கमৎ৑धधुप૗৲खऩः೩঻z .DSODQ0HLHUශ଍मઌभ
,,,,,,, ,,, ,,,,,,,,,,,, ,,,,,,, ,,,,, , ,,,,,,,,,,,,,, , ,, , ,,,,,,,, , ,㻜㻚㻞ᝈ⪅ID⩌A 䛥䜣

13,, ,, ,,B 䛥䜣

13C 䛥䜣

1D 䛥䜣E 䛥䜣F 䛥䜣,,,,,,

㻜㻚㻜㻜㻚㻜

㻜㻚㻡㻝㻚㻜 ୯඄॑ਢऐञधऌभমਊभেோফਯऋॎऊढञधघॊ4$/<॑পऌऎ௓৒
 4$/<ਰ঱भસ়
¾ YV㻝㻚㻡㻞㻚㻜㻞㻚㻡㻟㻚㻜Ṛஸ䛒䜚ຠ⏝್┿䛾
QALYほᐹQALY2NO

0.9

2.7

1.82NO

0.5

1.5

1.0

32NO0.20.60.4

133

YES

0.9

2.72.7

133

YES

0.5

1.5

1.5

133YES

0.2

0.60.6┿䛾ほᐹ⏕Ꮡᖺᩘ ⏕Ꮡᖺᩘ

㻽㻭㻸㼅

1516

ऩछ.DSODQ0HLHU১द4$/<भীഘ॑ਫखऎ௓೾दऌऩःभऊ

ऩछ.DSODQ0HLHU১द4$/<भীഘ॑ਫखऎ௓೾दऌऩःभऊz ਖ਻मઊठજैोञ೩঻भඞः্z .DSODQ0HLHU১मੲਾभऩःઊठજॉ॑ෘ৒

ᝈ⪅ID

⩌

┿䛾⏕Ꮡᖺᩘほᐹ⏕ᏑᖺᩘṚஸ
䛒䜚ຠ⏝್

┿䛾
QALY

ほᐹ
QALYA 䛥䜣

132

NO

0.9

2.7

1.8B 䛥䜣

132NO

0.5

1.5

1.0C 䛥䜣

132NO

0.2

0.60.4䐟䐠z ௴௄েோফਯमઌभেோফਯ॑੒೾खऩः ⋇ েோফਯदमੲਾभऩःઊठજॉz ௴௄4$/<मઌभ4$/<॑੒೾ ⋈ 4$/<दमੲਾभँॊઊठજॉ ஍৷கऋঢ়બघॊ4$/<भଁੑੰෲदमਛॉয়ञऩः
Cox et al. JRSS A 1992.

z ௓೾भෙॉ఻় ংॖ॔५भপऌऔ ઊठજॉभ୤ऋ੗ःऺन‫ؚ‬পऌः ೩঻৑द஍৷கप୷ऋँॊऺन‫ؚ‬পऌः¾ ৢଞ‫ؚ‬4$/<॑পऌऎৄ஋ुॊ্਱भংॖ॔५z ્पିਔघसऌ૾ய ණ৑दেோফਯृ஍৷கभীഘऋ౮ऩॊৃ়
¾ ණ৑ૻຎभ੠पংॖ॔५ऋৼ௨औोऩः

1718ৌ૪১‫؟‬,3&:১

ઊठજैोऩःન૨भ௓৒,QYHUVH3UREDELOLW\RI&HQVRULQJ:HLJKWHG১z েோফਯदੲਾभऩःઊठજॉभৃ়z ઊठજैोऩःન૨भಗਯदઊठજैोथःऩःॹ‫॑ॱش‬੎ातऐघॊ্১z $‫)ع‬औ॒भॹ‫ॱش‬भઊठજैोऩःન૨ ‫ع‬ফ‫؟‬¾ '‫)ع‬औ॒मযীੰෲष๾൴ᝈ⪅ID⩌┿䛾⏕Ꮡᖺᩘほᐹ⏕ᏑᖺᩘṚஸ
䛒䜚

A 䛥䜣

132NOB 䛥䜣

132NOC 䛥䜣

132NOD 䛥䜣

133YESE 䛥䜣

133YESF 䛥䜣

133YESᡴ䛱ษ䜙䜜䛺䛔☜⋡ ઊठજैोञ೩঻भॹ‫ऺ॑ॱش‬ऊभ೩঻ऋ๛৻ॎॉ ‫ع‬ফ‫؟‬ ઊठજॉ॑ॖঋথॺधखञ.DSODQ0HLHU১द௓৒

Zhao et al. Biometrika 1997.

㻝㻚㻜,,,,,,,,,,,, ,,, ,,, ,,,, ,,,, ,, ,,,,,,,,,,,, ,,,,,,, ,,, ,,,,,,,,,,,,,,,,,,,,, , ,,,,,, ,,,,, ,,,,,,,,, ,,,,, ,,,,,,,,,,,,,,,,,,,,

㻜㻚㻤,,,,,,,,,, ,,,,,,, ,, ,

㻜㻚㻢㻜㻚㻠

,,,, ,,,

 ઊठજैोऩःન૨

,,,,,, ,,,¾ ফ‫؟‬ফ‫؟‬¾ ফ‫؟‬ফ‫؟‬㻜㻚㻞㻜㻚㻜㻜㻚㻜㻜㻚㻡

㻝㻚㻜

㻝㻚㻡

,,,,,㻞㻚㻜㻞㻚㻡㻟㻚㻜⏕Ꮡᖺᩘ19๕஑৓ऩॹ‫ॱش‬प,3&:১॑ి৷㻽㻭㻸㼅䛾⏕Ꮡ๭ྜ㻝㻚㻜,,,,,,

㻜㻚㻤,,㻜㻚㻢,,,,,,, ,হ୻दभଁੑੰෲभ੶ൗ ગ㻵㻼㻯㼃ἲ㻷㼍㼜㼘㼍㼚㻙㻹㼑㼕㼑㼞ἲ┿䛾㻽㻭㻸㼅䛾ศᕸ,,,,,,,,,,,,, ,,, ,㻜㻚㻠z ,3&:১मઌभ4$/<भী,,,,,,,,,,, ,,,,,,, ,,,,

ഘपปअ, , ,,,,,,,,,,,,,, , ,, , ,,,,,

 ೩঻ਯऋ੗ऐोय঳ಱ,,, , ,㻜㻚㻞,, ,, ,,,,,,,,

㻜㻚㻜㻜㻚㻜㻜㻚㻡㻝㻚㻜㻝㻚㻡㻞㻚㻜㻞㻚㻡

20㻟㻚㻜

㻽㻭㻸㼅

z We used inverse probability weighting toestimate the mean […] QALYs, accounting forthe censored nature of these data.
z The weights were evaluated as the inverse ofKaplan Meier estimator of censoring probability.
z For QALYs […], we partitioned the study time
horizon in homogenous subintervals (quarterlyintervals) […]z Linear regression was used […]. We included
baseline EQ-5D scores as a covariate in theestimation of QALYs.

21ଢ଼஢਋৑॑ীસखथ,3&:১॑ి৷z ਴಑4$/< 4भ਴಑  4भ਴಑ 4भ਴಑  4भ਴಑ ‫ؚؚؚ‬ऊাऽदઊठજैोऩःન૨॑௓৒ ઊठજैोथःऩः4f4॑੎ातऐੰෲ ௓৒ಖ২भ਱঱ऋ਋ୄऔोॊຠ⏝್
122ණ৑द॔থংছথ५ऩऊা৯भ஍৷கz ਴಑(4'५॥॔भ௓୎0䛛᭶

3䛛᭶

6䛛᭶

9䛛᭶

12䛛᭶

䝬䝂䝑䝖⒪ἲ⩌

0.485

0.556

0.592

0.585

0.595

䝝䜲䝗䝻䝀䝹⩌

0.539

0.559

0.566

0.628

0.625

 ऊা৯दঁॖॻট।ঝණभ্ऋऺनৈः ছথॲ঒৲मखथःॊऋ‫ؚ‬4$/<षभ୶஭প

Manca et al. Health Econ 2005.

Q2Q103䛛᭶Q36䛛᭶z ঋ‫ش‬५ছॖথ஍৷கदभ৹ତ ၉ேभုॉभ৹ତQ49䛛᭶ ௓৒ಖ২‫؞‬ਫ਼লৡभ਱঱12䛛᭶Ramsey et al. Value Health 2015.

¾ फ़ॖॻছॖথदम৹ତ॑ਘऎਏ੷⏕Ꮡᖺᩘ23ৌ૪১‫؟‬4$/<भ৚షীෲ
z ,3&:১॑৷ःञ੎ाહऌ৚ష
௞ଵଶ௞଴௞ଵ ଵ ߚଵଵ ൅ ߚଶଵ ൅ ߚଷଵ ൅ ߚସଵ¾ ऊাऽदभ਴಑4$/<भ৹ତੋाණ৑୷ ఻৬৓पमਰৣभ௓৒୤॑ੑ઴
ఋீ ௑ೖ೔σ௡௜ୀଵ ෠ ೖ೔ ࢄ௜ ࢄ்௜ିଵহ୻दभ4$/<भੰෲ੥ટz ऊাऽदभ4$/<पණ৑୷मऩः
12䛛᭶䜎䛷䛾ᖹᆒQALY(95% ಙ㢗༊㛫)௞ଶ ଶ¾ Żණ‫ ؚ‬Żঋ‫ش‬५ছॖথ஍৷க

෡௞ ൌ
¾ࢼ

24

ఋ ொீ ௑ೖ೔σ௡௜ୀଵ ෠ೖ೔ ೖ೔ ࢄ௜෠ ‫ ݐ‬ઊठજॉपৌघॊ.DSODQ0HLHU௓৒୤
¾‫ܩ‬¾ ߜ௞ ય৑Ǝभॖঋথॺ੐ં૗ਯ‫ؚܺ‬௞ ય৑Ǝभઊठજॉન૨௬੼ৎਡ
Willan et al. Stat Med 2005.

䝬䝂䝑䝖⒪ἲ⩌0.551 (0.505, 0.591)

䝝䜲䝗䝻䝀䝹⩌0.540 (0.489, 0.589)⩌㛫ᕪ

0.011 (í0.067, 0.071)

 ઊठજॉ‫ؚ‬ঋ‫ش‬५ছॖথ஍৷கदभ৹ତੋा
¾ ঋ‫ش‬५ছॖথ஍৷க॑৹ତखऩऊढञैउजैऎණ৑୷भਡ௓৒கम଀z ા৷஍ટীෲदमَા৷ৌ஍ટम৊ಉُध੥૛

25

264$/<ੰෲदभ୯ਸभଁੑ৓ਵ਻

ऽधीz ા৷஍ટীෲपउऐॊા৷भଁੑੰෲz ઊठજॉ॑ൣअ4$/<भଁੑੰෲ

 4$/<ध৊஘भॹ‫ॱش‬ଡୗ

 .DSODQ0HLHU১ऩनभఏ૆৓ऩেோৎ৑ੰෲু১दम

ෙढञ௓೾भതो ા৷౐ਜ਼ৎ৑ਊञॉभા৷ ¼ েோফਯ
¾ 4$/< ஍৷க ¼ েோফਯ ిજऩੰෲ১भऱधणम,3&:১z ঋ‫ش‬५ছॖথ஍৷கदभ৹ତੰෲz েோফਯभਗዠ

 5&7भ୯඄਋৑म଒৒৓ ၉ேभုॉ॑৹ତ ଁੑ৓पളහद‫ु਻ୖؚ‬੗ः

 ,3&:১ ৚షীෲद ௓৒ಖ২‫؞‬ਫ਼লৡभ਱঱ ા৷஍ટীෲद੷ीैोॊऒधऋ੗ः
¾ ૞અ/DWLPHU11,&(76'27૞અધ൴zzহ୻ 8HQR,RND 7,NHGD0HWDO5DQGRPL]HGSKDVH,,,VWXG\RIJHPFLWDELQHSOXV66
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