‫؝ڭ‬ਞଵ੍ᙺඅ৵ుਞଵ੍ᙺඅ੎ඪ৅੿पৌघॊॖ९উটॸঞঀ‫ش‬ঝ੅ਢลো௜১भਫ਼ୈ‫؟‬१ঝঈॱঔ‫ش‬ঝ੅ਢลো௜১॑ৌසधखञ੗઱ਝુ৊੸੎ᆟਫ਼ছথॲ঒৲ૻຎ૥ୡ‫&ق‬,7५ॱॹॕ‫ك‬‫ॺ॔؝ڮ‬আ‫ش‬ਙຜჹ༇ჩ౩ୢপဟരਸ਼ਕ୰੹৵ుఐ৤ඖ ෥௟‫؝گ‬୫੟॔ঞঝॠ‫ش‬‫॔؝ڰ‬ঞঝॠ‫ش‬ਙ࿀༇‫ؚ‬ग॒ऽख॒ಉ‫॔؝‬ঞঝॠ‫ش‬৅ඪ੒ଆմऒƸ‫ݱ‬δưஇ‫ٶ‬Ʒॸࣱ၌धưƢմऒ඙ၲᲴGLƴǑǔ೅แ҄,&,7भਜ਼઼હऐम‫ؼ‬ࣱ࣯ႆ˺ᕤཋၲඥȗȩȳᲢᲬᲬ᳸ᲫᲯബᲣ‫ݱ‬ႆ˺И஖඙ၲᡙь඙ၲɶႆ˺‫ٻ‬ႆ˺E㻞่⃭⸆྾ධE㻞่⃭⸆཯᚟྾ධ㻻㻞྾ධධ㝔E㻞่⃭⸆཯᚟྾ධ
㻻㻞྾ධ䚸㍺ᾮ䝇䝔䝻䜲䝗⸆㟼ὀ䜰䝭䝜䝣䜱䝸䞁Ⅼ⁲E㻞่⃭⸆཯᚟྾ධ

䝇䝔䝻䜲䝗⸆ᢞ୚䠄㟼ὀ䞉⤒ཱྀ䠅㼍㼚㼐㻛㼛㼞䜰䝭䝜䝣䜱䝸䞁Ⅼ⁲NAEPP䠖⡿ᅜႍᜥ䜺䜲䝗䝷䜲䞁ǤǽȗȭȆȬȎȸȫਤዓԈλၲඥ䚸䝇䝔䝻䜲䝗⸆㟼ὀ཯᚟ᢘദȷᅹ‫ܖ‬ႎƳᚸ̖ƳƘžኺ᬴ႎſƴ).҄ƞǕƯƍǔᲨଐஜƩƚƷ඙ၲඥᲨɭမ೅แƱƷ᧓ƴᱨᱰᲨ᣻ၐႆ˺ƴ‫ݣ‬ƠŴ
SALਤዓԈλǛᘍƏICITƴ᧙Ƣǔᚡ᠍ă໯Ơ

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R/A
FiO2 40%ễẲถࢊ/ɧᏡദࠝ ɧ‫ר‬ሁMaxɶễẲễẲɶᓸଢദࠝ ˯ɦ/ᐻ‫ڠ‬ଣზஇᡈỉႆ˺Ჹᙺඅ५॥॔धखथ03,6॑৭৒खञ৶૓ 03,6मᙺඅ৅੿भ੎ඪ২धঢ়৴ँॊणभඨ৯॑૚‫ر‬஺మप५॥॔৲ख‫ؚ‬जभ়ੑகद௬੼औोॊ‫ق‬6S2‫ؚ‬ళลਯ‫ؚ‬ੱ༭ਯ‫ؚ‬ลਞళਞૻ‫ᙺؚ‬๥भங২‫౑ؚ‬ৡళลभங২‫؛ك‬ऒभɼᙲᚸ̖᪮Ⴘиഏᚸ̖᪮ႸPIǹǳǢોծ͌ᲢᲭ଺᧓ࢸᲣzPIǹǳǢᲢᲫᲬ଺᧓ࢸᲣzԠԈૠોծྙᲢᲭ଺᧓ࢸᲣ‫ࣱ࢘ڲ‬Ŵᚸ̖ᎍ᧓ƷȐȩȄǭǛஇ‫҄ݱ‬Ƣǔ߻‫پ‬ƕ࣏᪰Შअठลਞళਞૻ‫ᙺؚ‬๥भங২‫౑ؚ‬ৡళลम௬੼঻ऋ਌௴৓पਖ਼৒घॊඨ৯दँॊ‫؛‬ऒभञी૥ୡৰ઱प੔য়ठ‫ؚ‬૥ୡ૞ਸୢపपम'9'ઇ౫॑৷ःञঽഞ৾ಆ॑खथຘःञ‫؛‬ऽञ௬੼঻৔दभગਠਙ‫ؚ‬౮ऩॊ௬੼঻৑भ঳ಱ২॑೾৒ख‫ؚ‬५॥॔धखथभਦ౅২॑௬੼खञ‫؛‬3,५॥॔भਦ౅ਙ௬੼y ၴदु৊गக ٙ ௬੼঻৑ਦ౅ਙ‫ق‬,QWHU5DWHU5HOLDELOLW\‫ك‬૙஬ᲢCD, DVDᲣǛ˺ᙌŴᚸ̖ᎍ᧓ȷᚸ̖ᎍϋƷɟᐲྙȷϐྵࣱǛᄩᛐᲨăȈȬȸȋȳǰƷܱ଀ᲨPIἋἅỴӳᚘໜỉኢϋႻ᧙̞ૠ㘠ኢϋႻ᧙̞ૠᾉ὿ᵌᾈᾆᾇίҔᵋҔ὿ᵌᾈᾇẆҔᵋჃ὿ᵌᾈᾇὸ㘠ỽἕἣί
ίNὸ̞ૠᾉҔᵋҔẆҔᵋჃểờĢ὿ᵌᾇ ί᭗ẟɟᐲὸ'9'ઇ౫॑৷ःञ௬੼১भॺঞ‫ॽش‬থॢ‫ڀ‬ളਯभ௬੼঻ऋ৊ৎप൧௄ख‫ؚ‬৅੿੎ඪ২॑ਖ਼৒‫ڀ‬௬੼঻৑भ௬੼঳ಱ૨॑௬੼

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03,6द௬੼घॊŰƄƈƎƄƚƄ ŷŏŃŤƏƏƈƕƊƒƏƒƊƜ ŬƑƗ ŕœŔŗŞŃřŖŝŃřœŖŐřœŚᚾ᬴ỉ૾ඥ῍ỴỸἚἻỶὅ䡚ᾀബ῍ᵏᵖബச฼ỉൢሥૅմऒ᣻ၐႆ˺धᎍᵐ଺᧓ˌϋỆᵱᵟᵠᵟ᧓എԈλᵐ‫଀ׅ‬ᘍࢸỉᵮᵧἋἅỴầᵗໜˌɥộẺỊ И஖඙ၲỆợỤẵύᵮᵧἋἅỴầᵏᾄໜˌɥपঢ়घॊ੘௜ਾઔ‫ؚ‬எञठ‫ᙺق‬අ௧୅ୢ‫ك‬भ੘௜৽ୡेॉ‫ؚ‬໪ब੘௜৫઩৏ৎ৑ங২ऊैᙺඅ৅੿ඪ૾भ੝ఒ॑ੳीॊ೩঻ऋ੗ःऒध‫ؚ‬03,6௬੼भञीपम੅ਢลো‫ق‬෷ಞ‫॑ك‬ী৑র૵खथ6S2॑௬੼घॊ૑ਏऋँॊऒधऊै‫ँؚ‬ॊங২भ৅੿੝ఒऋৄ੢ऽोॊ૾ଙदभ௬੼ऋిਊधઅइञ‫؛‬ӷॖӕࢽἻὅἒἲл˄਌ਏ௬੼भৎ਋॑੘௜৫઩ৎ৑৏धखञ৶૓ૌுभ̣ඵౕఇ੅ਢลো௜১‫ق‬శ,&,7‫ك‬भ૛ધ‫ؚ‬ব৔भ,&,7ᢘ఍ࣱЙૺႇ᥵ỶἏἩἿἘἾἠὊἽ፭ἇἽἨἑἴὊἽ፭ᶊᵋỶἏἩἿἘἾἠὊἽਤዓԈλὺμ៲ࣱἋἘἿỶἛἇἽἨἑἴὊἽਤዓԈλὺμ៲ࣱἋἘἿỶἛ

ὉᵮᵧἋἅỴ‫҄٭‬᣽ίᾂ଺᧓ὸ

ᵮᵧἋἅỴίᵑ଺᧓ὸ

ᵮᵧἋἅỴίᵑ଺᧓ὸ

Ẕиഏᚸ̖᪮ႸẕᵮᵧἋἅỴίᵏᵐ଺᧓ὸᵮᵧἋἅỴίᵏᵐ଺᧓ὸᚾ᬴ᕤᾉἒἨἽἒἱὊ эẔɼᙲᚸ̖᪮Ⴘẕ

ὉᵮᵧἋἅỴ‫҄٭‬᣽ίᵏᵐ଺᧓ὸὉԠԈૠ‫ྙ҄٭‬ίᵑ଺᧓ὸὉ࣎ਊૠ‫ྙ҄٭‬ίᵑ଺᧓ὸ
Ὁμᑍોծࡇίᵑ଺᧓Ẇᵏᵐ଺᧓ὸᚾ᬴඙ၲί12hὸᚾ᬴඙ၲ‫ܦ‬ʕίᵏᵐ଺᧓ࢸὸ࣏ᙲỆࣖẳềਤዓԈλዒዓ

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ᚇ‫ݑ‬஖᧓ᾉਤዓԈλኳʕࢸᵐᵒ଺᧓ộỂਤዓԈλɶỆႆྵẲẺஊܹʙᝋỊ᠃࠙ửᄩᛐẴỦộỂᡙួᛦ௹20

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㻜2+ǹǳǢ‫҄٭‬᣽2+ǹǳǢ‫҄٭‬᣽㻙㻞㻠㻞㻙㻞㻜㻙㻞㻙㻠ⴭ᫂ᨵၿ䚷䚷䚷䚷ᨵ䚷ၿ䚷䚷䚷䚷䜔䜔ᨵၿ䚷䚷䚷䚷୙䚷ኚ䚷䚷䚷䚷䚷ᝏ䚷໬ⴭ᫂ᨵၿ䚷䚷䚷䚷ᨵ䚷ၿ䚷䚷䚷䚷䜔䜔ᨵၿ䚷䚷䚷䚷୙䚷ኚ䚷䚷䚷䚷䚷ᝏ䚷໬μᑍોծࡇμᑍોծࡇ㻙㻞㻙㻠㻙㻢㻙㻢㻙㻤㻙㻤㻙㻝㻜㻙㻝㻜㻙㻝㻞㻙㻜㻚㻢㻙㻜㻚㻠㻙㻜㻚㻞㻜㻜㻚㻞㻙㻝㻞㻙㻜㻚㻢㻜㻚㻠㻙㻜㻚㻠,&,7ᵮᵧἋἅỴ‫҄٭‬᣽ểԠԈૠ‫҄٭‬᣽
2+ǹǳǢ‫҄٭‬᣽ƱԠԈૠ‫ྙ҄٭‬᧏‫ ࢸ᧓଺ڼ‬P

2+ǹǳǢ‫҄٭‬᣽ƱԠԈૠ‫ྙ҄٭‬᧏‫ ࢸ᧓଺ڼ‬P㻙㻜㻚㻞㻜㻜㻚㻞㻜㻚㻠࣎ਊૠ‫ྙ҄٭‬࣎ਊૠ‫ྙ҄٭‬

6$/

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㻢2+ǹǳǢ‫҄٭‬᣽

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2+ǹǳǢ‫҄٭‬᣽Ʊ࣎ਊૠ‫ྙ҄٭‬᧏‫ ࢸ᧓଺ڼ‬P

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㻜㻚㻤َ॔क़ॺढ़঒੐ఏُदमँॉऽच॒ऋ
&44ઃਸ਼द‫ؚ‬৸ऎৄइऩऊढञऒधऋ‫ؚ‬ৄइञॉखऽघ‫؝‬

Asthma Phenotypes
henotypes
enoty
otyypes,/पৌघॊঔঀॡট‫ॼش‬ঝ

Late-onset
eosinophilicVeryLate-onset(woman)Th2Severityಿ৬मᙺඅ੝ఒ஍ટ॑થघॊऊ‫ء‬AllergicAsthma

Obesityassociated

EIAChild
Wenzel S., Nature Med 2012

Adult

Age at onset

Adult

Smooth muscle mediatedpaucigranulocyteᙺඅ୰ଙद੎ਏऩ१ॖॺढ़ॖথ

Smoking-associated,
neutrophilic

onn-type 2
Non

Non-Th2

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