Publication List of Motomu Kanai(1) “An Expeditious Total Synthesis of Dolastatin 10” Kiyoshi Tomioka, Motomu Kanai, and Kenji
Koga, Tetrahedron Letters, 32, (21), 2395-2398 (1991).
(2) “Enantioselective Conjugate Addition of Organocuprate Using a Chiral Amidophosphine
Ligand” Motomu Kanai, Kenji Koga, and Kiyoshi Tomioka, Tetrahedron Letters, 33, (37), 71937196 (1992).
(3) “Solvent Effect and NMR Behavior in a Chiral Amidophosphine Mediated Reaction ofOrganocuprate with Chalcone” Motomu Kanai, Kenji Koga, and Kiyoshi Tomioka, J. Chem. Soc.,
Chem. Commun., (16), 1248-1249 (1993).
(4) “Asymmetric Conjugate Addition of Organocopper-Amidophosphine Reagents to Cycloalkenones” Motomu Kanai and Kiyoshi Tomioka, Tetrahedron Letters, 35, (6), 895-898 (1994).
(5) “Origin of Regioselectivity in Electrophilic Reaction of Ambident Enaldimines” Kiyoshi
Tomioka, Tetsuji Okamoto, Motomu Kanai and Hiroshi Yamataka, Tetrahedron Letters, 35, (12),1891-1892 (1994).
(6) “Asymmetric Conjugate Addition of Organomagnesium Cuprates Controlled by StoichiometricAmount of Chiral Phosphine” Motomu Kanai and Kiyoshi Tomioka, Tetrahedron Letters, 36 (24),4273-4274 (1995).
(7) “Catalytic Asymmetric Conjugate Addition of Grignard Reagents Controlled by Copper(I)Chiral Bidentate Phosphine Complex” Motomu Kanai and Kiyoshi Tomioka, Tetrahedron Letters,
36 (24), 4275-4278 (1995).
(8) “Asymmetric Conjugate Addition Reaction of Organocopper Based on Metal Differentiating
Coordination. (Review in Japanese)” Motomu Kanai and Kiyoshi Tomioka, Organometallic News,2, 44-49 (1995).
(9) “Diastereoselective Thiophenol Addition to (S)-N--Unsaturated Carbonyl--trityloxymethyl-butyrolactams” Kiyoshi Tomioka, Aki Muraoka, and Motomu Kanai, J. Org. Chem., 60 (19),6188-6190 (1995).
(10) “Enantioselective Reaction of An Imine with Methyllithium Catalyzed by A Chiral Ligand”
Isao Inoue, Mitsuru Shindo, Kenji Koga, Motomu Kanai, and Kiyoshi Tomioka, Tetrahedron:
Asymmetry, 6, (10), 2527-2533 (1995).
(11) “Conformational Preference and Diastereoselectivity of (S)-N-(-Unsaturated Carbonyl)-trityloxymethyl--butyrolactam” Motomu Kanai, Aki Muraoka, Takanori Tanaka, Masami Sawada,
Nobuo Ikota and Kiyoshi Tomioka, Tetrahedron Letters, 36 (51), 9349-9352 (1995).
(12) “Theoretical Calculation-Based Reproduction of Thermodynamic, Kinetic Behaviors andCytotoxicity of Azasteganes. (Special Issue for the Memory of Prof. Yoshio Ban)” Kiyoshi
Tomioka, Motomu Kanai, and Nobuo Ikota, Heterocycles, 42 (1), 43-45 (1995).

1

(13) “Asymmetric Conjugate Addition Reaction of Organometallic Reagents (Review in Japanese)”
Motomu Kanai and Kiyoshi Tomioka, Kagaku, 51 (1), 64-65 (1996).
(14) “Catalytic Asymmetric Conjugate Addition Reaction of Organocopper (Review in Japanese)”
Motomu Kanai and Kiyoshi Tomioka, Farumasia, 32 (2), 171-174 (1996).
(15) “Catalytic Asymmetric Conjugate Addition Reaction of Organocopper Reagents (Review inJapanese)” Motomu Kanai, Yuichi Nakagawa, and Kiyoshi Tomioka, J. Syn. Org. Chem. Jpn., 54(6), 474-480 (1996).
(16) “Chiral Ligand Controlled Enantioselective Opening of Oxirane and Oxetane” Masashi
Mizuno, Motomu Kanai, Akira Iida and Kiyoshi Tomioka, Tetrahedron: Asymmetry, 7 (9), 24832484 (1996).
(17) “Structural Requirements of External, Chiral Amidophosphine Ligand for Asymmetric
Reaction of Organocopper Reagent” Yuichi Nakagawa, Motomu Kanai, Yasuo Nagaoka, andKiyoshi Tomioka, Tetrahedron Letters, 37 (43), 7805-7808 (1996).
(18) “A Ternary Complex-Reagent for An Asymmetric Reaction of Lithium Ester Enolates with
Imines” Hiroki Fujieda, Motomu Kanai, Takeshi Kambara, Akira Iida and Kiyoshi Tomioka J. Am.
Chem. Soc., 117 (8), 2060-2061 (1997).
(19) “Asymmetric Addition Reaction of Phenyllithium to 1,2-Ethylenediimine with An Aid of A
Chiral Ligand” Daisuke Taniyama, Motomu Kanai, Akira Iida and Kiyoshi Tomioka, Chem.
Pharm.Bull., 45 (10) 1705-1707 (1997).
(20) “An External Chiral Ligand Controlled Enantioselective Opening of Oxirane and Oxetane By
Organolithiums” Masashi Mizuno, Motomu Kanai, Akira Iida, and Kiyoshi Tomioka, Tetrahedron,53, 10699-10708 (1997).
(21) “Varying the Size of Multivalent Ligands: The Dependence of Concanavalin A Binding on
Neoglycopolymer Length” Motomu Kanai, Kathleen H. Mortell, Lauara L. Kiessling J. Am. Chem.
Soc., 119, 9931-9932 (1997).
(22) “Enantiselective Addition of Methyllithium to 2-Furaldehyde Imine with the Aid of Chiral
Ligand” Daisuke Taniyama, Motomu Kanai, Akira Iida, Kiyoshi Tomioka Heterocycles, 46165-168(1997).
(23) “Enantioselective Addition of Thiazolylithium to Aldimines with the Aid of Chiral Ligand.
Asymmetric Synthesis of (S)-DOE, a Component of Marine Natural Product, Dolastatin 10” Kiyoshi
Tomioka, Maki Satoh, Daisuke Taniyama, Motomu Kanai, and Akira Iida, Heterocycles, 47, 77-80(1998).
(24) “An External Chiral Amidophosphine Ligand for Asymmetric Conjugate Addition ofOrganocopper” Yuichi Nakagawa, Motomu Kanai, Yasuo Nagaoka, and Kiyoshi Tomioka
Tetrahedron 54, 10295-10307 (1998).
(25) “Structural Requirements of a Chiral Ligand for the Catalytic Asymmetric Addition of2

Thiophenol to -Unsaturated Esters” Kiyoshi Tomioka, Manabu Okuda, Katsumi Nishimura,
Shino Manabe, Motomu Kanai, Yasuo Nagaoka, and Kenji Koga Tetrahedron Lett. 39, 2141-2144(1998).
(26) “Linking BINOL: C2-symmetric Ligands for Investigations on Asymmetric Catalysis”
Erasmus M. Vogl, Shigeki Matsunaga, Motomu Kanai, Takehiko Iida, and Masakatsu Shibasaki
Tetrahedron Lett. 39, 7917-7920 (1998).
(27) “Catalytic Asymmetric Michael Addition of Nitromethane to Enones Controlled by (R)-LPB”
Ken Funabashi, Yoshinobu Saida, Motomu Kanai, Takayoshi Arai, Hiroaki Sasai, and Masakatsu
Shibasaki Tetrahedron Lett. 39, 7557-7558 (1998).
(28) “Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands
for Concanavalin A” David A. Mann, Motomu Kanai, Dustin J. Maly, and Laura Kiessling J. Am.
Chem. Soc., 120, 10575-10582 (1998).
(29) “Catalytic Enantioselective Conjugate Addition of Grignard Reagents to Cyclic Unsaturated Carbonyl Compounds” Motomu Kanai, Yuichi Nakagawa, Kiyoshi Tomioka
Tetrahedron 55, 3843-3854 (1999).
(30) “An Asymmetric Conjugate Addition Reaction of Lithium Organocopper Reagent Controlled
by a Chiral Amidophosphine” Motomu Kanai, Yuichi Nakagawa, Kiyoshi Tomioka Tetrahedron 55,
3831-3842 (1999).
(31) “Catalytic Asymmetric Addition of Diphenylphosphine oxide to Cyclic Imines” Koichi
Yamakoshi, Simon, J. Harwood, Motomu Kanai, Masakatsu Shibasaki Tetrahedron Lett. 40, 25652568 (1999).
(32) “A New Bifunctional Asymmetric Catalysis: An Efficient Catalytic Asymmetric
Cyanosilylation of Aldehydes” Yoshitaka Hamashima, Daisuke Sawada, Motomu Kanai, Masakatsu
Shibasaki J. Am. Chem. Soc., 121, 2641-2642 (1999).
(33) “Development of Lewis-Acid Lewis Base Bifunctional Asymmetric Catalyst” Motomu Kanai,
Yoshitaka Hamashima, Masakatsu Shibasaki Farumasia 35, 690-694 (1999).
(34) “Direct Chlorohydrin and Acetoxy Alcohol Synthesis from Olefins Promoted by a Lewis Acid,
Bis(trimethylsilyl) Peroxide and (CH3)3SiX” I. Sakurada, S. Yamasaki, R. Goetlich, T. Iida, M. Kanai,and M. Shibasaki J. Am. Chem. Soc. 122, 1245-1246 (2000).
(35) “Dichlorotin Oxide-catalyzed New Direct Functionalization of Olefins: Synthesis of trans Azidohydrins and 1,2-Diols” I. Sakurada, S. Yamasaki, M. Kanai and M. Shibasaki Tetrahedron Lett.,
41, 2415-2418 (2000).
(36) “Design of a New Bifunctional Asymmetric Catalyst from Carbohydrates: Application to
Catalytic Asymmetric Cyanosilylation of Aldehydes and Acetophenone” M. Kanai, Y. Hamashima
and M. Shibasaki Tetrahedron Lett., 41, 2405-2409 (2000).
(37) “A Catalytic Asymmetric Strecker-Type Reaction: Interesting Reactivity Difference between
3

TMSCN and HCN” M. Takamura, Y. Hamashima, H. Usuda, M. Kanai and M. Shibasaki Angew.
Chem. Int. Ed. 2000, 39, 1650-1652.
(38) “Asymmetric Reissert-type Reaction Promoted by Bifunctional Catalyst” M. Takamura, K.
Funabashi, M. Kanai, and M. Shibasaki J. Am. Chem. Soc., 122, 6327-6328 (2000).
(39) “Catalytic Enantioselective Cyanosilylation of Ketones” Y. Hamashima, M. Kanai, and M.
Shibasaki J. Am. Chem. Soc., 122, 7412-7413 (2000).
(40) “Highly Enantioselective Cyanosilylation of Aldehydes Catalyzed by a Lewis Acid-Lewis Base
Bifunctional Catalyst” Y. Hamashima, D. Sawada, H. Nogami, M. Kanai, and M. Shibasaki
Tetrahedron 2001, 57, 805-814.
(41) “Enantioselective Total Synthesis of Epothilone A and B Using Multifunctional Asymmetric
Catalysis” D. Sawada, M. Kanai and M. Shibasaki J. Am. Chem. Soc., 122, 10521-10532 (2000)(42) “A Catalytic Asymmetric Strecker-Type Reaction Promoted by Lewis Acid-Lewis Base
Bifunctional Catalyst” M. Takamura, Y. Hamashima, H. Usuda, M. Kanai, and M. Shibasaki Chem.
Pharm. Bull, 48, 1586-1592 (2000)(43) “Enantioselective Strecker-type reaction promoted by polymer-supported bifunctional catalyst”
H. Nogami, S. Matsunaga, M. Kanai and M. Shibasaki Tetrahedron Lett., 42, 279-283 (2001)(44) “Catalytic enantioselective cyanosilylation of ketones: improvement of enantioselectivity andcatalyst turn-over by ligand tuning” Y. Hamashima, M. Kanai and M. Shibasaki Tetrahedron Lett.,
2001, 42, 691-694.
(45) “Novel Multiaction of Zr Catalyst: One-Pot Synthesis of -Cyanohydrins from Olefins” S.
Yamasaki, M. Kanai, M. Shibasaki J. Am. Chem. Soc. 2001, 123, 1256-1257.
(46) “Anti- and Syn-Selective Cyanosilylation Reactions Promoted by a Sugar-Based Bifunctional
Catalyst: Stereoselctive Synthesis of Essential Building Blocks for HIV Protease Inhibitor andBestatin” Govindaswamy Manickam, Hiroyuki Nogami, Motomu Kanai, Harald Groeger, Masakatsu
Shibasaki Synlett 2001, 5, 617-620.
(47) “Multifunctional Asymmetric Catalysis” M. Shibasaki, M. Kanai Chem. Pharm. Bull. 49, 511524 (2001).
(48) “Catalytic Enantioselective Reissert-Type Reaction: Development and Application to theSynthesis of a Potent NMDA Receptor Antagonist (-)-L-689,560 Using a Solid-Supported Catalyst”
M. Takamura, K. Funabashi, M. Kanai, and M. Shibasaki J. Am. Chem. Soc., 123, 6801-6808 (2001)(49) “Zirconium Alkoxides in Catalysis” S. Yamasaki, M. Kanai, and M. Shibasaki Chem. Eur. J., 7,4066-4073 (2001)(50) “Development and Application of Enantioselective Lewis Acid-Lewis Base Bifunctional
Catalyst” M. Kanai, Y. Hamashima, M. Takamura, and M. Shibasaki Journal of Synthetic
Organic Chemistry, Japan, 59, 767-778 (2001)
4

(51) “Switching Enantiofacial Selectivities Using One Chiral Source: Catalytic Enantioselective
Synthesis of the Key Intermediate for (20S)-Camptothecin Family by (S)-Selective Cyanosilylationof Ketones” K. Yabu, S. Masumoto, S. Yamasaki, Y. Hamashima, M. Kanai, W. Du, D. P. Curran,and M. Shibasaki J. Am. Chem. Soc., 123, 9908-9909 (2001)(52) “Enantioselective Construction of Quaternary Stereocenter through a Reissert-Type Reaction
Catalyzed by an Electronically Tuned Bifunctional Catalyst: Efficient Synthesis of Various
Biologically Significant Compounds” K. Funabashi, H. Ratni, M. Kanai, and M. Shibasaki J. Am.
Chem. Soc., 123, 10784-10785 (2001)(53) “Development and Application of Enantioselective Lewis Acid–Lewis Base Bifunctional
Catalyst” M. Kanai Yakugaku Zasshi, 121, 949–960 (2001).
(54) “Studies toward the Total Synthesis of Garsubellin A: A Concise Synthesis of the 18-epiTricyclic Core” H. Usuda, M. Kanai, M. Shibasaki Org. Lett., 4, 859-862 (2002)(55) “Studies toward the total synthesis of garsubellin A: Synthesis of 8-deprenyl-garsubellin A” H.
Usuda, M. Kanai, M. Shibasaki Tetrahedron Lett., 43, 3621-3624 (2002)(56) “Control of Multivalent Interactions by Binding Epitope Density” C. W. Cairo, J. E. Gestwicki,
M. Kanai, L. L. Kiessling J. Am. Chem. Soc., 124, 1615-1619 (2002).
(57) “Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones”
Shuji Masumoto, Kazuo Yabu, Motomu Kanai and Masakatsu Shibasaki Tetrahedron Lett., 43, 29192922 (2002).
(58) “Studies toward practical synthesis of (20S)-camptothecin family through catalytic
enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning” Kazuo
Yabu, Shuji Masumoto, Motomu Kanai, Dennis P. Curran and Masakatsu Shibasaki Tetrahedron
Lett., 43, 2923-2926 (2002).
(59) “Recent progress in asymmetric two-center catalysis” M. Shibasaki, M. Kanai, K. Funabashi
Chem. Commun.1989-1999 (2002).
(60) “A General Catalytic Allylation Using Allyltrimethoxysilane” Shingo Yamasaki, Kunihiko Fujii,
Reiko Wada, Motomu Kanai, and Masakatsu Shibasaki J. Am. Chem. Soc. 124, 6536-6537 (2002).
(61) “Efficient Synthesis of Antihyperglycemic (S)--Aryloxy--phennylpropionic Acid Using a
Bifunctional Asymmetric Catalyst” Takamura, M.; Yanagisawa, H.; Kanai, M.; Shibasaki, M.
Chem. Pharm. Bull. 50, 1118-1121 (2002).
(62) “Dramatic Switching of Protein Kinase C Agonist/Antagonist Activity by Modifying the 12Ester Side Chain of Phorbol Esters”
Wada, R.; Suto, Y.; Kanai, M.; Shibasaki, M. J. Am. Chem.
Soc. 124, 10658-10659 (2002).
(63) “Enhancement of Lewis Acidity by Ligand-Defined Metal Geometry: A Catalytic Allylation of
Aldehydes with Allyltrimethylsilane” Kanai, M.; Kuramochi, A.; Fujii, K.; Shibasaki, M.
5

Synthesis, 1956-1958 (2002).
(64) “A Practical Synthesis of (S)-Oxybutynin” Masumoto, S.; Suzuki, M.; Kanai, M.; Shibasaki,
M. Tetrahedron Lett. 2002, 43, 8647–8651.
(65) “Catalytic Enantioselective Synthesis of (20S)-Camptothecin Intermediates Using
Cyanosilylation of Ketones Promoted by D-Glucose-Derived Lanthanide Catalyst” Yabu, K.;
Masumoto S.; Kanai, M.; Du, W.; Curran, D. P.; Shibasaki, M. Heterocycles, 59, 369-385 (2003).
(66) “Efficient Synthesis of a Key Intermediate of Neurokinin Receptor Antagonists Using a
Bifunctional Asymmetric Catalyst” Takamura, M.; Yabu, K.; Nishi, T.; Yanagisawa, H.; Kanai,
M.; Shibasaki, M. Synlett 2003, 353.
(67) “Application of the Lewis Acid–Lewis Base Bifunctional Asymmetric Catalysts to
Pharmaceutical Syntheses: Streoselective Chiral Building Block Syntheses of HIV Protease Inhibitorand 3–Adrenergic Receptor Agonist” Nogami, H.; Kanai, M. Shibasaki, M. Chem. Pharm. Bull.
2003, 51, 702-709.
(68) “Formal Catalytic Asymmetric Total Synthesis of Fostriecin” Fujii, K.; Maki, K.; Kanai, M.;
Shibasaki, M. Org. Lett. 2003, 5, 733-736.
(69) “Catalytic Enantioselective Strecker Reaction of Ketoimines” Masumoto, S.; Usuda, H.;
Suzuki, M.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 5634-5635.
(70) “A New Method for the Catalytic Aldol Reaction to Ketones” Oisaki, K.; Suto, Y.; Kanai, M.;
Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 5644-5645.
(71) “Direct Catalytic Aldol–Type Reaction Using RCH2CN” Suto, Y; Kumagai, N.; Matsunaga,
S.; Kanai, M.; Shibasaki, M. Organic Letters 2003, 5, 3147-3150.
(72) “Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic
Alkylation of Ketones: Me2Zn Addition to -Ketoesters” Funabashi K.; Jachmann, M.; Kanai, M.;
Shibasaki M. Angew. Chem. Int. Ed. 2003, 42, 5489-5492.
(73) “General and practical catalytic enantioselective Strecker reaction of ketoimines: significant
improvement through catalyst tuning by protic additives” Nobuki Kato, Masato Suzuki, Motomu
Kanai, and Masakatsu Shibasaki Tetrahedron Lett. 2004, 45, 3147-3151.
(74) “Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN
and stoichiometric amount of HCN” Nobuki Kato, Masato Suzuki, Motomu Kanai, and Masakatsu
Shibasaki Tetrahedron Lett. 2004, 45, 3153-3155.
(75) “Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of SubtypeSelective LPA-Receptor Agonists and an Antagonist” Yoko Tamaruya, Masato Suzuki, Goshu
Kamura, Motomu Kanai, Kotaro Hama, Kumiko Shimizu, Junken Aoki, Hiroyuki Arai, andMasakatsu Shibasaki Angew. Chem. Int. Ed. 2004, 43, 2834-2837.
(76) “Catalytic Enantioselective Allylboration of Ketones” Reiko Wada, Kounosuke Oisaki, Motomu
6Kanai, and Masakatsu Shibasaki J. Am. Chem. Soc. 2004, 126, 8910-8911.
(77) “New Entries in Lewis Acid-Lewis Base Bifunctional Asymmetric Catalyst: Catalytic
Enantioselective Reissert Reaction of Pyridine Derivatives” Eiko Ichikawa, Masato Suzuki, Kazuo
Yabu, Matthias Albert, Motomu Kanai, and Masakatsu Shibasaki J. Am. Chem. Soc. 2004, 126,
11808-11809.
(78) “Practical Synthesis of Chiral Ligands for Catalytic Enantioselective Cyanosilation of Ketones
and Ketoimines” Nobuki Kato, Daisuke Tomita, Keisuke Maki, Motomu Kanai, and Masakatsu
Shibasaki J. Org. Chem. 2004, 69, 6128-6130.
(79) “Catalytic Asymmetric Synthesis of (S)-Oxybutynin and a Versatile Intermediate for
Anitimuscarinic Agents” Shuji Masumoto, Masato Suzuki, Motomu Kanai, and Masakatsu Shibasaki
Tetrahedron 2004, 60, 10497-10504.
(80) “Challenge toward Structural Complexity Using Asymmetric Catalysis: Target-Oriented
Development of Catalytic Enantioselective Diels-Alder Reaction” Hiroyuki Usuda, Akiyoshi
Kuramochi, Motomu Kanai, and Masakatsu Shibasaki Org. Lett. 2004, 6, 4387-4390.
(81) “Catalytic Enantioselective Conjugate Addition of Cyanide to -Unsaturated N-Acylpyrroles”
Tsuyoshi Mita, Kazuki Sasaki, Motomu Kanai, Masakatsu Shibasaki J. Am. Chem. Soc. 2005, 127,
514–515.
(82) “Enantioselective Alkenylation and Phenylation Catalyzed by a Chiral CuF Complex” Daisuke
Tomita, Reiko Wada, Motomu Kanai, Masakatsu Shibasaki J. Am. Chem. Soc. 2005, 127, 4138–4139.
(83) “New Chiral Bis(diphenylphospholane) Ligands: Design, Synthesis, and Application to Catalytic
Enantioselective Aldol Reaction to Ketones” Kounosuke Oisaki, Dongbo Zhao, Yutaka Suto,
Motomu Kanai, Masakatsu Shibasaki Tetrahedron Lett. 2005, 46, 4325–4329.
(84) “Catalytic Enantioselective Synthesis of Key Intermediates for Triazol Antifungal Agents”
Masato Suzuki, Nobuki Kato, Motomu Kanai, Masakatsu Shibasaki Org. Lett. 2005, 7, 2527–2530.
(85) “Power of Cooperativity: Lewis Acid–Lewis Base Bifunctional Asymmetric Catalysis” Motomu
Kanai, Nobuki Kato, Eiko Ichikawa, Masakatsu Shibasaki Synlett 2005, 1491–1508.
(86) “Catalytic Enantioselective Desymmetrization of meso-N-Acylaziridines with TMSCN”
Tsuyoshi Mita, Ikuo Fujimori, Reiko Wada, Jianfeng Wen, Motomu Kanai, Masakatsu Shibasaki J.
Am. Chem. Soc. 2005, 127, 11252–11253.
(87) “Cu(I)-Catalyzed Direct Enantioselective Cross Aldol-Type Reaction of Acetonitrile” Yutaka
Suto, Riichiro Tsuji, Motomu Kanai, Masakatsu Shibasaki Org. Lett. 2005, 7, 3757–3760.
(88) “Total Synthesis of (±)-Garsubellin A” Akiyoshi Kuramochi, Hiroyuki Usuda, Kenzo
Yamatsugu, Motomu Kanai, Masakatsu Shibasaki J. Am. Chem. Soc. 2005, 127, 14200–14201.
(89) “Recent Progress in Lewis Acid-Lewis Base Bifunctional Asymmetric Catalysis” Motomu
Kanai, Nobuki Kato, Eiko Ichikawa, Masakatsu Shibasaki Pure Appl. Chem. 2005, 77, 2047-2052.
7

(90) “Catalyst-Controlled Asymmetric Synthesis of Fostriecin and 8-epi-Fostriecin” Keisuke Maki,
Rie Motoki, Kunihiko Fujii, Motomu Kanai, Takayasu Kobayashi, Shinri Tamura, Masakatsu
Shibasaki J. Am. Chem. Soc. 2005, 127, 17111-17117.
(91) “Synthetic Strategies of Fostriecin” Masakatsu Shibasaki, Motomu Kanai, Heterocycles 2005,
66, 727-741.
(92) “Chiral, Poly(Rare-Earth Metal) Complexes in Asymmetric Catalysis” Masakatsu Shibasaki,
Motomu Kanai, Shigeki Matsunaga, Aldrichimica Acta 2006, 39, 31-39.
(93) “Catalytic Asymmetric Total Synthesis of (+)-Lactacystin” Nobuhisa Fukuda, Kazuki Sasaki,
T. V. R. S. Sastry, Motomu Kanai, Masakatsu Shibasaki J. Org. Chem. 2006, 71, 1220-1225.
(94) “Assembly State of Catalytic Modules as Chiral Switches in Asymmetric Strecker Amino Acid
Synthesis” Nobuki Kato, Tsuyoshi Mita, Motomu Kanai, Buruno Therrien, Masaki Kawano,
KentaroYamaguchi, Hiroshi Danjo, Yoshihisa, Sei, Akihiro Sato, Sanae Furusho, Masakastu
Shibasaki J. Am. Chem. Soc. 2006, 128, 6768-6769.
(95) “De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso-Aziridines
with TMSN3” Yuhei Fukuta, Tsuyoshi Mita, Nobuhisa Fukuda, Motomu Kanai, Masakatsu Shibasaki
J. Am. Chem. Soc. 2006, 128, 6312-6313.
(96)“ Catalytic Enantioselective Allylation of Ketoimines” Reiko Wada, Tomoyuki Shibuguchi,
Sae Makino, Kounosuke Oisaki, Motomu Kanai, Masakatsu Shibasaki J. Am. Chem. Soc. 2006, 128,7687-7691.
(97) “Catalytic Enantioselective Aldol Reaction of Ketones” Kounosuke Oisaki, Dongbo Zhao,
Motomu Kanai, Masakatsu Shibasaki J. Am. Chem. Soc. 2006, 128, 7164-7165.
(98) “Design and Development of Subtype-Selective LPA Ligands Based on Sugar Skeleton (Review
in Japanese)” Rie Motoki, Motomu Kanai, Masakatsu Shibasaki MedChem News 2006, 16, 10-14.
(99) “Development of Catalytic Asymmetric Reactions Using Chiral Multifunctional Rare-Earth
Metal Catalyst (Review in Japanese)” Masakatsu Shibasaki, Motomu Kanai, Shigeki Matsunaga, TCI
Mail 2006, 131, 2-13.
(100) “Nucleophilic Activation of Alkenyl and Aryl Boronates by a Chiral CuIF Complex: Catalytic
Enantioselective Alkenylation and Arylation of Aldehydes” Daisuke Tomita, Motomu Kanai,
Masakatsu Shibasaki, Chem. Asian. J. 2006, 1, 161–166.
(101) “Identification of Potent, Selective Protein Kinase C Inhibitors Based on a Phorbol Skeleton”
Yamatsugu, K.; Motoki, R.; Kanai, M.; Shibasaki, M. Chem. Asian. J. 2006, 1, 314-321.
(102) “Dramatic Ligand Effect in Catalytic Asymmetric Reductive Aldol Reaction of Allenic Esters
to Ketones” Zhao, D.; Oisaki, K.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2006, 128, 1444014441.

8

(103) “Catalytic Enantioselective Alkenylation and Phenylation of Trifluoromethyl Ketones” Motoki,
R.; Tomita, D.; Kanai, M.; Shibasaki, M. Tetrahedron Lett. 2006, 47, 8083-8086.
(104) “Key Role of the Lewis Base Position in Asymmetric Bifunctional Catalysis: Design and
Evaluation of a New Ligand for Chiral Polymetallic Catalysts” Fujimori, I.; Mita, T.; Maki, K.; Shiro,
M.; Sato, A.; Furusho, S.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2006, 128, 16438-16439.
(105) “Total Synthesis of Lactacystin and Salinosporamide A” Shibasaki, M.; Kanai, M.; Fukuda, N.
Chem. Asian J. (Focus Review) 2007, 2, 20-38.
(106) “Second Generation Catalytic Asymmetric Synthesis of Tamiflu: Allylic Substitution Route”
Mita, T.; Fukuda, N.; Roca, F. X.; Kanai, M.; Shibasaki, M. Org. Lett. 2007, 9, 259-262.
(107) “A concise synthesis of Tamiflu: third generation route via the Diels-Alder reaction and theCurtius rearrangement” Yamatsugu, K.; Kamijo, S.; Suto, Y.; Kanai, M.; Shibasaki, M. Tetrahedron
Lett. 2007, 48, 1403-1406.
(108) “Catalytic Enantioselective Mannich-type Reactions of Ketoimines” Suto, Y.; Kanai, M.;
Shibasaki, M. J. Am. Chem. Soc. 2007, 129, 500-501.
(109) “Pd-Catalyzed allylic alkylation of secondary nitroalkanes” Maki, K.; Kanai, M.; Shibasaki, M.
Tetrahedron 2007, 63, 4250-4257.
(110) “Catalytic Asymmetric Synthesis of Biologically Active Molecules” Kanai, M.; Shibasaki, M.
J. Synth. Org. Chem., Jpn. 2007, 65, 439-449.
(111) “Catalytic Enantioselective Alkylative Aldol Reaction: Efficient Multicomponent-Assemblingof Dialkylzincs, Allenic Esters, and Ketones toward Highly Functionalized -Lactones with
Tetrasubstituted Chiral Center” Oisaki, K.; Zhao, D.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc.
2007, 129, 7439-7443.
(112) “A New Approach for the Construction of a Highly Congested Bicyclic System in Polycyclic
Polyprenylated Acylphloroglucinols (PPAPS)” Shimizu, Y.; Kuramochi, A.; Usuda, H.; Kanai, M.;
Shibasaki, M. Tetrahedron Lett. 2007, 48, 4173-4177.
(113) “Toward a rational design of the assembly structure of polymetallic asymmetric catalysts:
design, synthesis, and evaluation of new chiral ligands for catalytic asymmetric cyanation reactions”
Fujimori, I.; Mita, T.; Maki, K.; Shiro, M.; Sato, A.; Furusho, S.; Kanai, M.; Shibasaki, M.
Tetrahedron 2007, 63, 5820-5831.
(114) “Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rareearth metal complexes” Shibasaki, M.; Kanai, M. Org. Biol. Chem. 2007, 5, 2027-2039.
(115) “Copper(I) Alkoxide-Catalyzed Alkynylation of Trifluoromethyl Ketones” Motoki, R.; Kanai,
M.; Shibasaki, M. Org. Lett. 2007, 9, 2997-3000.
(116) “Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-MediatedLysophosphatidic Acid Signaling in Mice” Hama, K.; Aoki, J.; Inoue, A.; Endo, T.; Amano, T.;
9Motoki, R.; Kanai, M.; Ye, X.; Chun, J.; Matsuki, N.; Suzuki, H.; Shibasaki, M.; Arai, H. Biol.
Reproduction 2007, 77, 954-959.
(117) “A Method for the Synthesis of an Oseltamivir PET Tracer” Morita, M.; Sone, T.; Yamatsugu,
K.; Sohtome, Y.; Matsunaga, S.; Kanai, M.; Watanabe, Y.; Shibasaki, M. Bioorg. Med. Chem. Lett.
2008, 18, 600-602.
(118) “Pharmacologic Action of Oseltamivir on the Nervous System” K. Ishii, H. Hamamoto, T.
Sasaki, Y. Ikegaya, K. Yamatsugu, M. Kanai, M. Shibasaki, K. Sekimizu, Drug Discoveries &Therapeutics, 2008, 2, 24-34.
(119) “P-Glycoprotein Restricts the Penetration of Oseltamivir across the Blood-Brain Barrier” A.
Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita, A. Yamamoto, Y. Sugiyama,
Drug Metab. Dispos. 2008, 36, 427-434.
(120) “Oseltamivir Enhances Hippocampal Network Synchronization” A. Usami, T. Sasaki, N. Satoh,T. Akiba, S. Yokoshima, T. Fukuyama, K. Yamatsugu, M. Kanai, M. Shibasaki, N. Matsuki, Y.
Ikegaya, J. Pharmacol. Sci. 2008, 106, 659-662.
(121) “Synthetic Strategies for Oseltamivir Phosphate” M. Shibasaki, M. Kanai Eur. J. Org. Chem.
2008, 1839-1850.
(122) “A Catalytic Enantioselective Conjugate Addition of Cyanide to Enones” Tanaka, Y.; Kanai,
M.; Shibasaki, M. J. Am. Chem. Soc. 2008, 130, 6072-6073.
(123) “Cu(I)-catalyzed asymmetric allylation of ketones and ketimines” Kanai, M.; Wada, R.;
Shibuguchi, T.; Shibasaki, M. Pure Appl. Chem. 2008, 80, 1055-1062.
(124) “Asymmetric Synthesis of Tertiary Alcohols and α-Tertiary Amines via Cu-Catalyzed C−C
Bond Formation to Ketones and Ketimines” Shibasaki, M.; Kanai, M. Chem. Rev. 2008, 108, 28532873.
(125) “Catalytic Conjugate Addition of Cyanide to Enones: Cooperative Catalysis of Ni(0) andGd(OTf)3” Tanaka, Y.; Kanai, M.; Shibasaki, M. Synlett 2008, 2295-2298.
(126) “Asymmetric Reductive Mannich Reaction to Ketimines Catalyzed by a Cu(I) Complex” Du,Y.; Xu, W.; Shimizu, Y.; Oisaki, K.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2008, 130, 1614616147.
(127) “Cu(I)-Catalyzed Hetero-Diels–Alder Reaction between Danishefsky-Type Siloxy Dienes and
Ketones” Chen, I.-H.; Oisaki, K.; Kanai, M.; Shibasaki, M. Org. Lett. 2008, 10, 5151-5154.
(128) “A Synthesis of Tamiflu by Using a Barium-Catalyzed Asymmetric Diels–Alder-Type
Reaction” Yamatsugu, K.; Yin, L.; Kamijo, S.; Kimura, Y.; Kanai, M.; Shibasaki, M. Angew. Chem.,
Int. Ed. 2009, 48, 1070–1076 (featured by Synfacts 2009, 702).
(129) “Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-Amino-3-(1-Ethoxypropoxy)-1Cyclohexene-1-Carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of10

Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter
3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)” Ose, A.; Ito, M.;
Kusuhara, H.; Yamatsugu, K.; Kanai, M.; Shibasaki, M.; Hosokawa, M.; Schuetz, J. D.; Sugiyama,
Y. Drug Metab. Disp. 2009, 37, 321-329.
(130) “Two Methods for Catalytic Generation of Reactive Enolates Promoted by a Chiral Poly Gd
Complex: Application to Catalytic Enantioselective Protonation Reactions” Morita, M.; Drouin, L.;
Motoki, R.; Kimura, Y.; Fujimori, I.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2009, 131, 3858–
3859 (featured by Synfacts 2009, 626).
(131) “Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by
autotaxin in blood” Tomoko Endo, Kuniyuki Kano, Rie Motoki1, Kotaro Hama, Shinichi Okudaira,
Mayuko Ishida, Hideo Ogiso, Masayuki Tanaka, Norio Matsuki, Ryo Taguchi, Motomu Kanai,
Masakatsu Shibasaki, Hiroyuki Arai, and Junken Aoki J. Biochem. 2009, 146, 283–293.
(132) “Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil
Chemotaxis” Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga,
Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko
Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A. Frohman, Yoshinori
Fukui Science 2009, 324, 384-387.
(133) “Design and Synthesis of Immobilized Tamiflu Analog on Resin for Affinity Chromatography”
Kimura, Y.; Yamatsugu, K.; Kanai, M.; Echigo, N.; Kuzuhara, T.; Shibasaki, M. Tetrahedron Lett.
2009, 50, 3205-3208 (50th anniversary issue).
(134) “Enantioselective Synthesis of SM-130686 Based on the Development of Asymmetric Cu(I)F
Catalysis To Access 2-Oxindoles Containing a Tetrasubstituted Carbon” Tomita, D.; Yamatsugu, K.;
Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2009, 131, 6946–6948.
(135) “An alternative synthesis of Tamiflu®: a synthetic challenge and the identification of aruthenium-catalyzed dihydroxylation route” Yamatsugu, K.; Kanai, M.; Shibasaki, M. Tetrahedron
2009, 65, 6017–6024.
(136) “Nucleophile Generation via Decarboxylation: Asymmetric Construction of Contiguous
Trisubstituted and Quaternary Stereocenters through a Cu(I)-Catalyzed Decarboxylative MannichType Reaction” Yin, L.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2009, 131, 9610–9611 (featured
by Synfacts 2009, 1111).
(137) “Catalytic Asymmetric Synthesis of Chiral Tertiary Organoboronic Esters through Conjugate
Boration of -Substituted Cyclic Enones” Chen, I.-H.; Yin, L.; Itano, W.; Kanai, M.; Shibasaki, M.
J. Am. Chem. Soc. 2009, 131, 11664–11665.
(138) “Recent Progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems”
Shibasaki, M.; Kanai, M.; Matsunaga, S.; Kumagai, N. Acc. Chem. Res. 2009, 42, 1117–1127.
(139) “Catalytic Asymmetric Total Synthesis of ent–Hyperforin” Shimizu, Y.; Shi, S.-L.; Ususda,
H.; Kanai, M.; Shibasaki, M. Angew. Chem., Int. Ed. 2010, 49, 1103–1106 (featured by Chem. & Eng.
News 2010, Jan. 25, p 28).
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(140) “Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography”
Kimura, Y.; Yamatsugu, K.; Kanai, M.; Echigo, N.; Kuzuhara, T.; Shibasaki, M. Bull. Korean Chem.
Soc. 2010, 31, 588–594 (dedication issur to Professor Sunggak Kim).
(141) “Identification of Modular Chiral Bisphosphines Effective for Cu(I)-Catalyzed Asymmetric
Allylation and Propargylation of Ketones” Shi, S.-L.; Xu, L.-W.; Oisaki, K.; Kanai, M.; Shibasaki，
M. J. Am. Chem. Soc. 2010, 132, 6638–6639.
(142) “Catalytic Asymmetric Synthesis of R207910” Saga, Y.; Motoki, R.; Makino, S.; Shimizu, Y.;
Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2010, 132, 7905-7907.
(143) “Catalytic Enantioselective Construction of -Quaternary Carbons via a Conjugate Addition of
Cyanide to ,-Disubstituted ,-Unsaturated Carbonyl Compound” Tanaka, Y.; Kanai, M.;
Shibasaki, M. J. Am. Chem. Soc. 2010, 132, 8862-8863.
(144) “The First Catalytic Asymmetric Total Synthesis of ent-Hyperforin” Shimizu, Y.; Shi, S.-L.;
Usuda, H.; Kanai, M.; Shibasaki, M. Tetrahedron 2010, 33, 6569-6584.
(145) “Copper(I)−Secondary Diamine Complex-Catalyzed Enantioselective Conjugate Boration ofLinear β,β-Disubstituted Enones” Chen, I.-H.; Kanai, M.; Shibasaki, M. Org. Lett. 2010, 12, 4098–
4101 (featured by Synfacts 2010, 1253).
(146) “Lewis Acid Catalyzed Benzylic C−H Bond Functionalization of Azaarenes: Addition to
Enones” Komai, H.; Yoshino, T.; Matsunaga, S.; Kanai, M. Org. Lett. 2011, 13, 1706–1709.
(147) “Recent Development in Synthetic Strategies for Oseltamivir Phosphate” Shibasaki, M.; Kanai,M.; Yamatsugu, K. Isr. J. Chem. 2011, 51, 316–328.
(148) “Catalytic Asymmetric Ring-Opening of meso-Aziridines with Malonates under
Heterodinuclear Rare Earth Metal Schiff Base Catalysis” Xu, Y.; Lin, L.; Kanai, M.; Matsunaga, S.;
Shibasaki, M. J. Am. Chem. Soc. 2011, 133, 5791-5793.
(149) “A Facile Pathway to Enantiomerically Enriched 3-Hydroxy-2-Oxindoles: Asymmetric
Intramolecular Arylation of α-Keto Amides Catalyzed by a Palladium–DifluorPhos Complex” Yin,
L.; Kanai, M.; Shibasaki, M. Angew. Chem., Int. Ed. 2011, 50, 7620-7623.
(150) “Catalytic Migratory Oxidative Coupling of Nitrones” Hashizume, S.; Oisaki, K.; Kanai, M.
Org. Lett. 2011, 13, 4288-4291.
(151) “Catalytic Migratory Oxidative Coupling of Nitrones through an Outer-Sphere C(sp3)-H
Activation Process” Hashizume, S.; Oisaki, K.; Kanai, M. Chem. Rec. 2011, 5, 236-241.
(152) “Cu(I)-Catalyzed Decarboxylative Aldol-Type and Mannich-Type Reactions For AsymmetricConstruction Of Contiguous Trisubstituted and Quaternary Stereocenters” Yin, L.; Kanai, M.;
Shibasaki, M. Tetrahedron 2012, 68, 3497-3506.
(153) “Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed
Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions” Shi, S.-L.; Kanai, M.; Shibasaki, M.
Angew. Chem. Int. Ed. 2012, 51, 3932-3935.
(154) “Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine
through Double Michael Reaction of Bisoxindole” Mitsunuma, H.; Shibasaki, M.; Kanai, M.;
Matsunaga, S. Angew. Chem. Int. Ed. 2012, 51, 5217-5221.
12

(155) “Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator
DOCK2” Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, Qinhong Cao, Yuji Okamura, Takashi
Saitoh, Nae Saito, Shunsuke Sakaoka, Yao Du, Atsushi Suenaga, Mutsuko Kukimoto-Niino, Kei
Miyano, Kazuhito Gotoh, Takayoshi Okabe, Fumiyuki Sanematsu, Yoshihiko Tanaka, Hideki
Sumimoto, Teruki Honma, Shigeyuki Yokoyama, Tetsuo Nagano, Daisuke Kohda, Motomu Kanai,
Yoshinori Fukui Chem. & Biol. 2012, 19, 488-497.
(156) "Mg-catalyzed Enantioselective Benzylic C-H Bond Functionalization of Isoindolinones:
Addition to Imines" Yudai Suzuki, Motomu Kanai, Shigeki Matsunaga Chem. Eur. J. 2012, 18, 7654–
7657.
(157) "Lewis Acid Catalyzed Benzylic C-H Bond Functionalization of Azaarenes; Addition to Imines
and Enones" Komai, H.; Yoshino, T.; Matsunaga, S.; Kanai, M. Synthesis 2012, 44, 2185–2194.
(158) “Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of
Isothiocyanato Oxindoles” Shota Kato, Tatsuhiko Yoshino, Masakatsu Shibasaki, Motomu Kanai and
Shigeki Matsunaga Angew. Chem. Int. Ed. 2012, 51, 7007-7010.
(159) “Functional-Group-Tolerant Catalytic Migratory Oxidative Coupling of Nitrones” Shogo
Hashizume, Kounosuke Oisaki and Motomu Kanai, Chem. Asian J. 2012, 7, 2600–2606.
(160) “Cu(I)-catalyzed α-alkylation of ketones with styrene derivatives” Shohei Majima, Yohei
Shimizu, Motomu Kanai, Tetrahedron Lett. 2012, 53, 4381-4384.
(161) “Catalytic aerobic production of imines en route to mild, green, and concise derivatizations ofamines” Toshiaki Sonobe, Kounosuke Oisaki, Motomu Kanai, Chem. Sci. 2012, 3, 3249–3255.
(162) “Rhodium-Catalyzed Cross-Aldol Reaction: In Situ Aldehyde-Enolate Formation from
Allyloxyboranes and Primary Allylic Alcohols” Luqing Lin, Kumiko Yamamoto, Shigeki Matsunaga,
Motomu Kanai, Angew. Chem. Int. Ed. 2012, 51, 10275–10279.
(163) “Copper(I)-Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the
Synthesis of Versatile Alkaloid Precursors” Shi, S.-L.; Wei, X.-F.; Shimizu, Y.; Kanai, M. J. Am.
Chem. Soc. 2012, 134, 17019–17022.
(164) “Synthesis of a New Oseltamivir Derivative Through Late-Stage Catalytic C-HFunctionalization” Kenta Saito, Motomu Kanai Heterocycles 2013, 86, 1565-1574.
(165) “Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug
form of the anti-influenza agent oseltamivir” Miki Hiasa, Yumiko Isoda, Yasushi Kishimoto, Kenta
Saitoh, Yasuaki Kimura, Motomu Kanai, Masakatsu Shibasaki, Dai Hatakeyama, Yutaka Kirino,
Takashi Kuzuhara British J. Pharmacology 2013, 169, 115-129.
(166) “A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic
Organometallic Species: Directed C-H Bond Activation” Yoshino, T. Ikemoto, H.; Matsunaga, S.;
Kanai, M. Angew. Chem. Int. Ed. 2013, 52, 2207–2211.
(167) “Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines” Takashi Andou, Yutaka Saga,
Hirotomo Komai, Shigeki Matsunaga, Motomu Kanai Angew. Chem. Int. Ed. 2013, 52, 3213-3216.
(168) “Copper-Catalyzed C–H Alkoxylation of Azoles” Noriaki Takemura, Yoichiro Kuninobu,
Motomu Kanai Org. Lett. 2013, 15, 844-847.
13

(169) “Intracellular activation of acetyl-CoA by an artificial reaction promoter and its fluorescentdetection” Hirokazu Komatsu, Yutaka Shindo, Shigehiro A. Kawashima, Kenzo Yamatsugu, Kotaro
Oka, Motomu Kanai Chem. Commun. 2013, 49, 2876-2878.
(170) “Iron-Catalyzed Oxidative C(3)–H Functionalization of Amines” Noriaki Takasu, Kounosuke
Oisaki, and Motomu Kanai Org. Lett. 2013, 15, 1918–1921.
(171) “Catalytic Asymmetric Synthesis of Spirooxindoles via Addition of Isothiocyanato Oxindoles
to Aldehydes Under Dinuclear Nickel Schiff Base Catalysis” Shota Kato, Motomu Kanai, Shigeki
Matsunaga, Chem. Asian J. 2013, 8, 1768–1771.
(172) “Sultam Synthesis via Cu-Catalyzed Intermolecular Carboamination of Alkenes with NFluorobenzenesulfonimide” Keiichi Kaneko, Tatsuhiko Yoshino, Shigeki Matsunaga, Motomu Kanai
Org. Lett. 2013, 15, 2502–2505.
(173) “From Chiral Base Catalysts to Redox-Active Catalysts: Chasing the Identity of Metal Catalysts
in Carbon–Carbon Bond-Forming Reactions” Motomu Kanai, Shigeki Matsunaga, Kounosuke Oisaki,
Yohei Shimizu J. Synth. Org. Chem. Japan 2013, 71, 433-442.
(174) “In situ Catalytic Generation of Allylcopper Species for Asymmetric Allylation: Toward 1HIsochromene Skeletons” Junya Kawai, Prasanna Kumara Chikkade, Yohei Shimizu and Motomu
Kanai Angew. Chem. Int. Ed. 2013, 52, 7177–7180.
(175) “Cp*CoIII-Catalyzed C2-Selective Addition of Indoles to Imines” Tatsuhiko Yoshino, Hideya
Ikemoto, Shigeki Matsunaga and Motomu Kanai Chem. Eur. J. 2013, 19, 9142–9146.
(176) “Manganese-Catalyzed Aerobic Dehydrogenative Cyclization toward Ring-Fused Indole
Skeletons” Oisaki, K.; Abe, J.; Kanai, M. Org. Biomol. Chem. 2013, 11, 4569–4572.
(177) “Copper-Catalyzed Intramolecular N–S Bond Formation by Oxidative Dehydrogenative
Cyclization” Zhen Wang, Yoichiro Kuninobu, Motomu Kanai, J. Org. Chem. 2013, 78, 7337–7342.
(178) “Catalytic Anomeric Aminoalkynylation of Unprotected Aldoses” Kimura, Y.; Ito, S.; Shimizu,
Y.; Kanai, M. Org. Lett. 2013, 15, 4130–4133.
(179) “Catalytic Asymmetric Synthesis of Spirooxindoles via Addition of Isothiocyanato Oxindoles
to Aldehydes Under Dinuclear Nickel Schiff Base Catalysis” Shota Kato, Motomu Kanai, Shigeki
Matsunaga, Chem. Asian J. 2013, 8, 1768-1771.
(180) “Rhenium-Catalyzed Synthesis of 3-Imino-1-isoindolinones by C–H Bond Activation:
Application to the Synthesis of Polyimide Derivatives” Shunsuke Sueki, Yuanfang Guo, Motomu
Kanai, Yoichiro Kuninobu, Angew. Chem. Int. Ed. 2013, 52, 11879-11883.
(181) “Rh-Catalyzed Aldehyde–Aldehyde Cross-Aldol Reaction under Base-Free Conditions: In Situ
Aldehyde-Derived Enolate Formation through Orthogonal Activation” Luqing Lin, Kumiko
Yamamoto, Shigeki Matsunaga, Motomu Kanai, Chem. Asian J. 2013, 8, 2974–2983.
(182) “Structure-activity relationship study of novel iminothiadiazolo-1 pyrimidinone antimicrobial
agents” Atmika Paudel, Keiichi Kaneko, Ayako Watanabe, Shigeki Matsunaga, Motomu Kanai,
Hiroshi Hamamoto, Kazuhisa Sekimizu, J. Antibiotics 2013, 66, 663-667.

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(183) “Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic
Photooxygenation” Taniguchi, A.; Sasaki, D.; Shiohara, A.; Iwatsubo, T.; Tomita, T.; Sohma, Y.;
Kanai, M. Angew. Chem. Int. Ed. 2014, 53, 1382-1385.
(184) “Enantioselective Synthesis of Spirooxindoles via Direct Catalytic Asymmetric Aldol-Type
Reaction of Isothiocyanato Oxindoles” Shota Kato, Motomu Kanai, Shigeki Matsunaga,
Heterocycles, 2014, 88, 475-491.
(185) “A Catalytic C-C Bond-Formation with Minimal Use of Protecting Groups: Construction of
Functionalized Isotetronic Acid Derivatives” Yohei Shimizu, Kouji Yasuda, Motomu Kanai,
Heterocycles, 2014, 88, 919-927.
(186) “Cobalt-Catalyzed C-4 Selective Alkylation of Quinolines” Yamamoto, S.; Saga, Y.; Andou,T.; Matsunaga, S.; Kanai, M. Adv. Synth. Cat. 2014, 356, 401-405.
(187) “Catalytic enantioselective synthesis of 2-(2-hydroxyethyl)indole scaffolds via consecutive
intramolecular amido-cupration of allenes and asymmetric addition of carbonyl compounds”
Prasanna Kumara Chikkade, Yohei Shimizu, Motomu Kanai, Chem. Sci. 2014, 5, 1585–1590.
(188) “Regioselective Trifluoromethylation of N-Heteroaromatic Compounds using
Trifluoromethyldifluoroborane Activator” Nishida, T.; Ida, H.; Kuninobu, Y.; Kanai, M. Nat.
Commun. 2014, 5, 3387–3392 (doi:10.1038/ncomms4387).
(189) “Synthesis of Pyridine N-Oxide–BF2CF3 Complexes and Their Fluorescence Properties”
Tomoaki Nishida, Aiko Fukazawa, Eriko Yamaguchi, Hiroya Oshima, Shigehiro Yamaguchi,
Motomu Kanai, Yoichiro Kuninobu, Chemistry Asian J. 2014, 9, 1026–1030.
(190) “Copper-Catalyzed Intramolecular C(sp3)–H and C(sp2)–H Amidation by Oxidative
Cyclization” Zhen Wang, Jizhi Ni, Yoichiro Kuninobu, Motomu Kanai, Angew. Chem. Int. Ed. 2014,
53, 3496–3499.
(191) “Copper-Catalyzed Benzylic C(sp3)-H Alkoxylation of Heterocyclic Compounds” Takemura,N.; Kuninobu, Y.; Kanai, M. Org. Biomol. Chem. 2014, 12, 2528–2532.
(192) “Palladium-Catalyzed C–H Fluorosilylation of 2-Phenylpyridines: Synthesis of Silafluorene
Equivalents” Qing Xiao, Xiangtai Meng, Motomu Kanai, Yoichiro Kuninobu, Angew. Chem. Int. Ed.
2014, 53, 3168–3172.
(193) “Asparagine-Selective Cleavage of Peptide Bonds through Hypervalent Iodine-MediatedHofmann Rearrangement in Neutral Aqueous Solution” Kana Tanabe, Atsuhiko Taniguchi, Takuya
Matsumoto, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai, Chem. Sci. 2014, 5, 2747 – 2753.
(194) “Palladium-Catalyzed Direct C–H Silylation and Germanylation of Benzamides andCarboxamides” Kyalo Stephen Kanyiva, Yoichiro Kuninobu, Motomu Kanai, Org. Lett. 2014, 16,
1968–1971.
(195) “Pyrroloindolone Synthesis via a Cp*CoIII-Catalyzed Redox-Neutral Directed C–H
Alkenylation/Annulation Sequence” Hideya Ikemoto, Tatsuhiko Yoshino, Ken Sakata, Shigeki
Matsunaga, Motomu Kanai, J. Am. Chem. Soc. 2014, 136, 5424–5431.
(196) “Air-Stable Carbonyl(pentamethylcyclopentadienyl)cobalt Diiodide Complex as a Precursor
for Cationic (Pentamethylcyclopentadienyl)cobalt(III) Catalysis: Application for Directed C-2
15

Selective C-H Amidation of Indoles” Sun, B.; Yoshino, T.; Matsunaga, S.; Kanai, M. Adv. Synth.
Catal. 2014, 356, 1491–1495.
(197) “Copper-Catalyzed Regio- and Stereoselective Intermolecular Three-Component Oxyarylationof Allenes” Itoh, T.; Shimizu, Y.; Kanai, M. Org. Lett. 2014, 16, 2736–2739.
(198) “Recent progress in copper-catalyzed difunctionalization of unactivated carbon-carbon
multiple bonds” Shimizu, Y.; Kanai, M. Tetrahedron Lett. 2014, 55, 3727–3737.
(199) “Chemoselective aerobic oxidation catalyzed by a metal/stable organoradical redox conjugate”
Seki, Y.; Oisaki, K.; Kanai, M. Tetrahedron Lett. 2014, 55, 3738–3746.
(200) “Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper
Organoradical Conjugate” Seki, Y.; Tanabe, K.; Sasaki, D.; Sohma, Y.; Oisaki, K.; Kanai, M. Angew.
Chem. Int. Ed. 2014, 53, 6501–6505.
(201) “Rational Design and Identification of Non-Peptidic Aggregation Inhibitor of Amyloid-beta
Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]” Tadamasa Arai,
Takushi Araya, Daisuke Sasaki, Atsuhiko Taniguchi, Takeshi Sato, Youhei Sohma, Motomu Kanai,
Angew. Chem. Int. Ed. 2014, 53, 8236–8239.
(202) “Regiodivergent Kinetic Resolution of Terminal and Internal rac-Aziridines with Malonates
under Dinuclear Schiff Base Catalysis“ Yingjie Xu, Keiichi Kaneko, Motomu Kanai, Masakatsu
Shibasaki, and Shigeki Matsunaga, J. Am. Chem. Soc. 2014, 136, 9190–9194.
(203) “Reaction mediated artificial cell termination: control of vesicle viability using Rh(I)-catalyzedhydrogenation” Hirokazu Komatsu, Yuki Daimon, Kohsaku Kawakami, Motomu Kanai, Jonathan P.
Hillad, Katsuhiko Ariga, Phys. Chem. Chem. Phys. 2014, 16, 16454-16457.
(204) “Molybdenum-Mediated Desulfurization of Thiols and Disulfides” Zhen Wang, Yoichiro
Kuninobu, Motomu Kanai, Synlett 2014, 25, 1869-1872.
(205) “Chemoselective aerobic photo-oxidation of 9H-fluorenes for the synthesis of 9-fluorenones”
Masahiro Kojima, Kounosuke Oisaki, Motomu Kanai, Tetrahedron Lett. 2014, 55, 4736-4738.
(206) “Copper-Mediated Direct C(sp3)-H and C(sp2)-H Acetoxylation” Wang, Z.; Kuninobu, Y.;
Kanai, M. Org. Lett., 2014, 16, 4790–4793.
(207) “A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less Toxic
Off-Pathway Amyloid-beta Oligomers” Tadamasa Arai; Daisuke Sasaki; Takushi Araya; Takeshi
Sato; Youhei Sohma; Motomu Kanai, ChemBioChem, 2014, 15, 2577–2583.
(208) “Structure-based design and synthesis of a bivalent iminobiotin analog showing strong affinity
toward a low immunogenic streptavidin mutant” Kawato, T.; Mizohata, E.; Shimizu, Y.; Meshizuka,
Y.; Yamamoto, T.; Takasu, N.; Matsuoka, M.; Matsumura, H.; Kodama, T.; Kanai, M.; Doi, H.; Inoue,T.; Sugiyama, A. Bioscience, Biotechnology, and Biochemistry 2015, 79, 640–642.
(209) “A Cp*CoI2-dimer as a precursor for cationic Co(III)-catalysis: application to C-H
phosphoramidation of indoles” Sun, B.; Yoshino, T.; Matsunaga, S.; Kanai, M. Chem. Commun. 2015,
51, 4649–4661.
(210) “Design and synthesis of biotin analogues reversibly binding with streptavidin” Yamamoto, T.;
Aoki, K.; Sugiyama, A.; Doi, H.; Kodama, T.; Shimizu, Y.; Kanai, M. Chem. Asian J. 2015, 10,1071–1078.
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(211) “Structure-based design of a streptavidin mutant specific for an artificial biotin analogue”
Kawato, T.; Mizohata, E.; Shimizu, Y.; Mshizuka, T.; Yamamoto, T.; Takasu, N.; Matsuoka, M.;
Matsumura, H.; Kodama, T.; Kanai, M.; Doi, H.; Inoue, T.; Sugiyama, A. J. Biochem. 2015, 157,
467–475.
(212) “Cp*Co(III)-catalyzed oxidative C-H alkenylation of benzamides with ethyl acrylate” Suzuki,
Y.; Sun, B.; Yoshino, T.; Kanai, M.; Matsunaga, S., Tetrahedron 2015, 71, 4552–4556.
(213) “Iridium-Catalyzed ortho-Selective C-H Silylation of Aromatic Compounds Directed toward
the Synthesis of π-Conjugated Molecules with Lewis Acid-Base Interaction” Wakaki, T.; Kanai, M.;
Kuninobu, Y. Org. Lett. 2015, 17, 1758–1761.
(214) “Copper-Catalyzed Intermolecular C(sp3)-H Bond Functionalization Towards the Synthesis of
Tertiary Carbamates” Chikkade, P. K.; Kuninobu, Y.; Kanai, M. Chem. Sci. 2015, 6, 3195–3200.
(215) “Palladium-Catalyzed Construction of Heteroatom-Containing π-Conjugated Systems by
Intramolecular Oxidative C-H/C-H Coupling Reaction” Saito, K.; Chikkade, P. K.; Kanai, M.;
Kuninobu, Y. Chem. Eur. J. 2015, 21, 8365–8368.
(216) “Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation”
Wang, Z.; Kuninobu, Y.; Kanai, M. J. Am. Chem. Soc. 2015, 137, 6140–6143.
(217) “Metal-free C(3)-H arylation of coumarins promoted by catalytic amounts of 5,10,15,20tetrakis(4-diethylaminophenyl)porphyrin” Kojima, M.; Oisaki, K.; Kanai, M. Chem. Commun. 2015,
51, 9718–9721.
(218) “Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif”
Kino, R.; Araya, T.; Arai, T.; Sohma, Y.; Kanai, M. Bioorg. Med. Chem. Lett. 2015, 25, 2972–2975.
(218) “Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic
properties” Shinoda, K.; Sohma, Y.; Kanai, M. Bioorg. Med. Chem. Lett. 2015, 25, 2976–2979.
(219) “Chemoselective Boron-Catalyzed Nucleophilic Activation of Carboxylic Acids for MannichType Reactions” Morita, Y.; Yamamoto, T.; Nagai, H.; Shimizu, Y.; Kanai, M. J. Am. Chem. Soc.
2015, 137, 7075–7078.
(220) “Organocatalytic Aerobic Oxdation to α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room
Temperature” Kadoh, Y.; Tashiro, M.; Oisaki, K.; Kanai, M. Adv. Synth. Catal. 2015, 357, 21932198.
(221) “Dehydrative Direct C-H Allylation with Allylic Alcohols under [Cp*CoIII] Catalysis” Suzuki,
Y.; Sun, B.; Sakata, K.; Yoshino, T.; Matsunaga, S.; Kanai, M. Angew. Chem. Int. Ed. 2015, 54, 99449947.
(222) “A meta-selective C–H borylation directed by a secondary interaction between ligand andsubstrate” Yoichiro Kuninobu, Haruka Ida, Mitsumi Nishi, Motomu Kanai Nature Chemistry 2015,
7, 712-717.
(223) “Benzylic C(sp3)-H Perfluoroalkylation of 6-Membered Heteroaromatic Compounds” Yoichiro
Kuninobu, Masahiro Nagase, Motomu Kanai Angew. Chem. Int. Ed. 2015, 54, 10263-10266.
(224) “Cp*CoIII Catalyzed Site-Selective C–H Activation of Unsymmetrical O-Acyl Oximes:
Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes” Bo Sun, Dr.
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Tatsuhiko Yoshino, Motomu Kanai, Shigeki Matsunaga Angew. Chem. Int. Ed. 2015, 54, 1296812972.
(225) “Copper-Catalyzed Oxyboration of Unactivated Alkenes” Itoh, T.; Matsueda, T.; Shimizu, Y.;
Kanai, M. Chem. Eur. J. 2015, 21, 15955–15959.
(226) “Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of
Trisulfonated Calix[4]arenes” Kimura, Y.; Saito, N.; Hanada, K.; Liu, J.; Okabe, T.; Kawashima, S.
A.; Yamatsugu, K.; Kanai, M. ChemBioChem 2015, 16, 2599–2604.
(227) “Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for the Rapid andFlexible Synthesis of 1,3-Polyols” Lin, L.; Yamamoto, K.; Mitsunuma, H.; Kanzaki, Y.; Matsunaga,
S.; Kanai, M. J. Am. Chem. Soc. 2015, 137, 15418–15421.
(228) “Chemo- and Regioselective Oxygenation of C(sp3)-H Bonds in Aliphatic Alcohols Using a
Covalently Bound Directing Activator and Atmospheric Oxygen“ Ozawa, J.; Tashiro, M.; Ni, J.;
Oisaki, K.; Kanai, M. Chem. Sci. 2016, 7, 1904-1909.
(229) “An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent
Propargylation of Unprotected Aldoses” X.-F. Wei, Y. Shimizu, M. Kanai, ACS. Cent. Sci. 2016, 2,
21–26.
(230) "Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondaryC(sp3)-H bonds in aliphatic alcohols" Ni, J.; Ozawa, J.; Oisaki, K.; Kanai, M. Org. Biomol. Chem.
2016, 14, 4378–4381.
(231) "Ligand-Promoted, Boron-Mediated Chemoselective Carboxylic Acid Aldol Reaction" Nagai,
H.; Morita, Y.; Shimizu, Y.; Kanai, M. Org. Lett. 2016, 18, 2276−2279.
(232) “4-Position-Selective C–H Perfluoroalkylation and Perfluoroarylation of Six-Membered
Heteroaromatic Compounds” Masahiro Nagase, Yoichiro Kuninobu, and Motomu Kanai, J. Am.
Chem. Soc. 2016, 138, 6103−6106.
(233) “Rhenium-Catalyzed Synthesis of 1,3-Diiminoisoindolines via Insertion of Carbodiimides intoa C-H Bond of Aromatic and Heteroaromatic Imidates” Wang, Z.; Sueki, S.; Kanai, M.; Kuninobu,
Y. Org. Lett. 2016, 18, 2459–2462.
(234) “Cp*CoIII-Catalyzed Dehydrative C-H Allylation of 6-Arylpurines and Aromatic Amides
Using Allyl Alcohols in Fluorinated Alcohols” Bunnno, Y.; Murakami, N.; Suzuki, Y.; Kanai, M.;
Yoshino, T.; Matsunaga, S. Org. Lett. 2016, 18, 2216–2219.
(235) “Ligand-Enabled, Copper-Catalyzed Regio- and Stereoselective Synthesis of
Trialkylsubstituted Alkenylboronates from Unactivated Internal Alkynes” Itoh, T.; Shimizu, Y.;
Kanai, M. J. Am. Chem. Soc. 2016, 138, 7528−7531.
(236) "Switchable Photooxygenation Catalysts that Sense Higher-Order Amyloid Structures"
Taniguchi, A.; Shimizu, Y.; Oisaki, K.; Sohma, Y.; Kanai, M. Nat. Chem. 2016, 8, 974–982.
(237) “Enhanced Structural Variety of Nonplanar N-Oxyl Radical Catalysts and Their Application to
the Aerobic Oxidation of Benzylic C-H Bonds” Kadoh, Y.; Oisaki, K.; Kanai, M. Chem. Pharm. Bull.
2016, 64, 737–753.
(238) “5-Position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives” Kuninobu, Y.;
Nishi, M.; Kanai, M. Org. Biomol. Chem. 2016, 14, 8092–8100.
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(239) “Transition Metal-Free, Tryptophan-Selective Bioconjugation of Proteins” Seki, Y.; Ishiyama,T.; Sasaki, D.; Abe, J.; Sohma, Y.; Oisaki, K.; Kanai, M. J. Am. Chem. Soc. 2016, 138, 10798–10801.
(240) “Tris(pentafluorophenyl)borane-Catalyzed Acceptorless Dehydrogenation of N-Heterocycles”
Kojima, M.; Kanai, M. Angew. Chem. Int. Ed. 2016, 55, 12224–12227.
(241) “Copper(I)-Catalyzed Dehydrative C-Glycosidation of Unprotected Pyranoses with Ketones”
Wei, X.-F.; Shi, S.-L.; Xie, X.-W.; Shimizu, Y.; Kanai, M. ACS Catal. 2016, 6, 6718–6722.
(242) “Lewis Acid-Base Interaction-Controlled ortho-Selective C-H Borylation of Aryl Sulfides”
Hong Liang Li, Yoichiro Kuninobu, Motomu Kanai Angew. Chem. Int. Ed. 2017, 56, 1495- 1499.
(243) “Scandium(III) triflate-promoted serine/threonine selective peptide bond cleavage” Jizhi Ni,
Youhei Sohma, Motomu Kanai Chem. Commun. 2017, 53, 3311–3314.
(244) “Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles
and Tetrahydronaphthalenes” Shota Kato, Yutaka Saga, Masahiro Kojima, Hiromu Fuse, Shigeki
Matsunaga, Arisa Fukatsu, Mio Kondo, Shigeyuki Masaoka, Motomu Kanai J. Am. Chem. Soc. 2017,
139, 2204–2207.
(245) “Silver-Catalyzed C(sp3)–H Chlorination” Jun Ozawa, Motomu Kanai, Org. Lett. 2017, 19,
1430–1433.
(246) “Copper(I)-Catalyzed Enantioselective Addition of Enynes to Ketones” Xiao-Feng Wei, XiaoWei Xie, Yohei Shimizu, and Motomu Kanai, J. Am. Chem. Soc. 2017, 139, 4647–4650.
(247) “Iron-Catalyzed Acyloxyalkylation of Styrenes Using Hypervalent Iodine Reagents” Z Wang,
M Kanai, Y Kuninobu, Org. Lett. 2017, 19, 2398–2401.
(248) “Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of
DOCK1” Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga,
Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima,
Fumiyuki Sanematsu, Teruki Honma, Takaho Terada, Eiji Oki, Senji Shirasawa, Yoshihiko Maehara,
Dongchon Kang, Jean-François Côté, Shigeyuki Yokoyama, Motomu Kanai, Yoshinori Fukui, Cell
Reports 2017, 19, 969–980.
(249) “Stereoselective Synthesis of Tetrasubstituted Alkenes via a Cp*CoIII‐Catalyzed C− H
Alkenylation/Directing Group Migration Sequence” H Ikemoto, R Tanaka, K Sakata, M Kanai, T
Yoshino, S Matsunaga, Angew. Chem. Int. Ed. 2017, 56, 7156–7160.
(250) “Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone
Acylation of Native Chromatin” Yoshifumi Amamoto, Yuki Aoi, Nozomu Nagashima, Hiroki Suto,
Daisuke Yoshidome, Yasuhiro Arimura, Akihisa Osakabe, Daiki Kato, Hitoshi Kurumizaka,
Shigehiro A. Kawashima, Kenzo Yamatsugu, and Motomu Kanai, J. Am. Chem. Soc. 2017, 139,
7568–7576.
(251) “Synthetic Chromatin Acylation by an Artificial Catalyst System” Tadashi Ishiguro, Yoshifumi
Amamoto, Kana Tanabe, Jiaan Liu, Hidetoshi Kajino, Akiko Fujimura, Yuki Aoi, Akihisa Osakabe,
Naoki Horikoshi, Hitoshi Kurumizaka, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai,
Chem 2017, 2, 840–859.
(252) “Ligand-Free, Copper-Catalyzed Aerobic Benzylic sp3 C-H Oxygenation” Hirotaka Tanaka,
Kounosuke Oisaki, Motomu Kanai, Synlett 2017, 28, 1576–1580.

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(253) “Iridium/Bipyridine-Catalyzed ortho-Selective C–H Borylation of Phenol and Aniline
Derivatives” Hong-Liang Li, Motomu Kanai, Yoichiro Kuninobu, Org. Lett. 2017, 19, 5944–5947.
(254) “Boron-Catalyzed Carboxylic Acid-Selective Aldol Reaction with Trifluoromethyl Ketones”
Kouhei Ishizawa, Hideoki Nagai, Yohei Shimizu, Motomu Kanai, Chem. Pharm. Bull. 2018, 66, 231–234.
(255) “LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins
to acylated nucleosomes” Tanabe, K.; Liu, J.; Kato, D.; Kurumizaka, H.; Yamatsugu, K.; Kanai,M.; Kawashima, S. A. Sci. Rep. 2018, 8, 2656–2666.
(256) “Total synthesis of (+)-lysergic acid” Rentaro Kanno, Satoshi Yokoshima, Motomu Kanai,
Tohru Fukuyama, J. Antibiot. 2018, 71, 240–247.
(257) “DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by selfactivating Rac1 P29S mutation” Takahiro Tomino, Hirotada Tajiri, Takaaki Tatsuguchi, Takahiro
Shirai, Kounosuke Oisaki, Shigeki Matsunaga, Fumiyuki Sanematsu, Daiji Sakata, Tomoharu
Yoshizumi, Yoshihiko Maehara, Motomu Kanai, Jean-Francois Cote, Yoshinori Fukui, Takehito
Uruno, Biochem. Biophys. Res. Commun., 2018, 497, 298–304.
(258) “Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero) Aryl Halides
via CH Bond Activation” Takayuki Wakaki, Takaya Togo, Daisuke Yoshidome, Yoichiro Kuninobu,
Motomu Kanai, ACS Catal., 2018, 8, 3123–3128.
(259) “2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives” Takahiro Shirai,
Motomu Kanai, and Yoichiro Kuninobu, Org. Lett., 2018, 20, 1593–1596.
(260) “Acceptorless Dehydrogenation of Hydrocarbons by Noble-Metal-Free Hybrid Catalyst
System” Hiromu Fuse, Masahiro Kojima, Harunobu Mitsunuma, Motomu Kanai, Org. Lett. 2018, 20,
2042-2045.
(261) “Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide” Jizhi Ni, Atsuhiko
Taniguchi, Shuta Ozawa, Yukiko Hori, Yoichiro Kuninobu, Takashi Saito, Takaomi C. Saido,
Taisuke Tomita, Youhei Sohma, Motomu Kanai, Chem, 2018, 4, 807–820.
(262) “C(sp3)–H Cyanation Promoted by Visible‐Light Photoredox/Phosphate Hybrid Catalysis”
Takayuki Wakaki, Kentaro Sakai, Takafumi Enomoto, Mio Kondo, Shigeyuki Masaoka, Kounosuke
Oisaki, Motomu Kanai, Chem. Eur. J. 2018, 24, 8051–8055.
(263) “Leading approaches in synthetic epigenetics for novel therapeutic strategies” Kenzo
Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai, Current Opinion in Chemical Biology, 2018,46, 10–17.
(264)“Organophotoredox/Copper
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Aminodecarboxylation of β, γ-Unsaturated Carboxylic Acids” AD Manick, H Tanaka, K Oisaki, M
Kanai, Synthesis 2018, 50, 2936–2947.
(265) “Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic
Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids” Taiki
Fujita, Tomohiro Yamamoto, Yuya Morita, Hongyu Chen, Yohei Shimizu, and Motomu Kanai, J.
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(266) “Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylationand chromosomal localization of shugoshin proteins” Tadashi Ishiguro, Kana Tanabe, Yuki
Kobayashi, Shinsuke Mizumoto, Motomu Kanai, Shigehiro A. Kawashima, Sci. Rep. 2018, 8, 7671.
(267) “Copper(I)‐Catalyzed Enantio‐ and Diastereodivergent Borylative Coupling of Styrenes andImines” Taisuke Itoh, Yamato Kanzaki, Yohei Shimizu, Motomu Kanai, Angew. Chem. Int. Ed. 2018,57, 8265–8269.
(268) “Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation
catalysts” Kenzo Yamatsugu, Masahiro Furuta, Siqi Xi, Yoshifumi Amamoto, Jiaan Liu, Shigehiro
A. Kawashima, Motomu Kanai, Bioorg. Med. Chem. 2018, 26, 5359–5367.
(269) “A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch
for fibril formation" Masashi Yamamoto, Kiyomichi Shinoda, Jizhi Ni, Daisuke Sasaki, Motomu
Kanai, Youhei Sohma, Org. Biomol. Chem. 2018, 16, 6537–6542.
(270) "A Catalytic One-step Synthesis of Peptide Thioacids: The Synthesis of Leuprorelin via
Iterative Peptide-fragment Coupling Reactions" Takuya Matsumoto, Koki Sasamoto, Ryo Hirano,
Kounosuke Oisaki, Motomu Kanai, Chem. Commun. 2018, 54, 12222–12225.
(271) "Hydroxy Group Directed Catalytic Hydrosilylation of Amides" Jizhi Ni, Tsubasa Oguro, Taka
Sawazaki, Youhei Sohma, Motomu Kanai, Org. Lett. 2018, 20, 7371–7374.
(272) "Convergent and Functional-Group-Tolerant Synthesis of B-Organo BODIPYs" Taka
Sawazaki, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai, Org. Lett. 2018, 20,
7767–7770.
(273) "Palladium-Catalyzed C-H Heteroarylation of 2,5-Disubstituted Imidazoles" Takaya Togo,
Youhei Sohma, Yoichiro Kuninobu, Motomu Kanai, Chem. Pharm. Bull. 2019, 67, 196–198.
(274) "Catalytic, Regio- and Enantio-Selective Proton Migration from Skipped Enynes to Allenes"
Xiao-Feng Wei, Takayuki Wakaki, Taisuke Itoh, Hong-Liang Li, Takayshi Yoshimura, Aya
Miyazaki, Kounosuke Oisaki, Miho Hatanaka, Yohei Shimizu, Motomu Kanai, Chem 2019, 5, 585–
599. DOI: 10.1016/j.chempr.2018.11.022(275) “Catalytic Asymmetric Allylation of Aldehydes with Alkenes through Allylic C (sp3)‒H
Functionalization Mediated by Organophotoredox and Chiral Chromium Hybrid Catalysis”
Harunobu Mitsunuma, Shun Tanabe, Hiromu Fuse, Kei Ohkubo, Motomu Kanai, Chem. Sci. 2019,10, 3459–3465.
(276) “Hydrogen Bond-Accelerated meta-Selective CH Borylation of Aromatic Compounds andExpression of Functional Group and Substrate Specificities” Xu Lu, Yusuke Yoshigoe, Haruka Ida,
Mitsumi Nishi, Motomu Kanai, Yoichiro Kuninobu, ACS Catal. 2019, 9, 1705−1709.
(277) “Design and properties of [Met35 (O)] Aβ42-lactam (Asp23/Lys28) possessing a lactam tether
as a salt-bridge surrogate” Masashi Yamamoto, Kiyomichi Shinoda, Daisuke Sasaki, Motomu Kanai,
Youhei Sohma, Bioorg. Med. Chem. 2019, 27, 888–893.
(278) “Molecular mechanism of lysophosphatidic acid-induced hypertensive response” Kuniyuki
Kano, Hirotaka Matsumoto, Asuka Inoue, Hiroshi Yukiura, Motomu Kanai, Jerold Chun, Satoshi
Ishii, Takao Shimizu, Junken Aoki, Scientific Reports 2019, 9, 2662.

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(279) “Photo-oxygenation inhibits tau amyloid formation” Takanobu Suzuki, Yukiko Hori, Taka
Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Youhei Sohma,
Motomu Kanai, Taisuke Tomita, Chem. Commun. 2019, 55, 6165–6168.
(280) “Site-selective synthetic acylation of a target protein in living cells promoted by a chemical
catalyst/donor system” Wataru Hamajima, Akiko Fujimura, Yusuke Fujiwara, Kenzo Yamatsugu,
Shigehiro A. Kawashima, Motomu Kanai, ACS Chem. Biol. 2019, 14, 1102–1109.
(281) “Copper(I)-Catalyzed Stereodivergent Propargylation of N-Acetyl Mannosamine for Protecting
Group Minimal Synthesis of C3-Substituted Sialic Acids” Kouhei Ishizawa, Sohei Majima, XiaoFeng Wei, Harunobu Mitsunuma, Yohei Shimizu, Motomu Kanai, J. Org. Chem. 2019, 84, 10615–
10628.
(282) “Synthetic Methodology-Driven Chemical Protein Modifications” Katsuya Maruyama,
Motomu Kanai, Chem. Lett. 2019, 48, 1421–1432.
(283) “Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl
BODIPYs” Atsuhiko Taniguchi, Taka Sawazaki, Yusuke Shimizu, Youhei Sohma, Motomu Kanai,Med. Chem. Commun. 2019, 10, 1121–1125.
(284) “Amine-Tethered Phenylboronic Acid-Enabling Ring-Opening Strategy for Carbon Chain
Elongation from Double Aldol Cyclic Hemiacetals” Yamato Kanzaki, Yuki Hirao, Harunobu
Mitsunuma, Motomu Kanai, Org. Biomol. Chem. 2019, 17, 6562-6565.
(285) “Nanoscale view of amyloid photodynamic damage” Patricia Bondia, Joaquim Torra, Caterina
M. Tone, Taka Sawazaki, Adrián del Valle, Begoña Sot, Santi Nonell, Motomu Kanai, Youhei Sohma,
Cristina Flors, J. Am. Chem. Soc. 2020, 142, 922–930.
(286) "Identification of Bond‐Weakening Spirosilane Catalyst for Photoredox α‐C-H Alkylation of
Alcohols" Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai, Adv. Synth. Catal. 2020, 362, 337–343.
(287) "Design, synthesis, and properties of a chemically-tethered amyloid-β segment trimer resistant
to inter-trimer mis-aggregation" Kiyomichi Shinoda, Motomu Kanai, Yohei Sohma J. Org. Chem.
2020, 85, 1635–1643.
(288) "Catalytic Chemoselective O-Phosphorylation of Alcohols" K. Domon, M. Puripat, K.
Fujiyoshi, M. Hatanaka, S. A. Kawashima, K. Yamatsugu and M. Kanai ACS Cent. Sci. 2020, 6, 283–
292.
(289) “Catalytic Acceptorless Dehydrogenation of Aliphatic Alcohols” Hiromu Fuse, Harunobu
Mitsunuma, Motomu Kanai J. Am. Chem. Soc. 2020, 142, 4493−4499.
(290) "Hydroxamic Acid‐Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under
Physiological Conditions" Shinsuke Mizumoto, Siqi Xi, Yusuke Fujiwara, Shigehiro A. Kawashima,
Kenzo Yamatsugu, Motomu Kanai Chem. Asian J. 2020, 15, 833-839.
(291) "A Stable and Cleavable O-Linked Spacer for Drug Delivery Systems" Kei Ito, Toshifumi
Tatsumi, Kazuki Takahashi, Yohei Shimizu, Kenzo Yamatsugu, Motomu Kanai Chem. Pharm. Bull.
2020, 68, 212-215.
(292) “Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction
toward folate-receptor-positive cancer cells” Hiroshi Tagawa, Katsuya Maruyama, Koichi Sasaki,
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Natsuki Konoue, Akihiro Kishimura, Motomu Kanai, Takeshi Mori, Kounosuke Oisaki, Yoshiki
Katayama RSC Adv. 2020, 10, 16727-16731. DOI: 10.1039/d0ra03291c.
(293) “A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C–H
Alkylation of Alcohols" Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai Synthesis 2020, 52, 2171–
2189.
(294) “Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in
Peptide/Protein Synthesis” Kento Ohkawachi, Daishiro Kobayashi, Kyohei Morimoto, Akira
Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai, Akira Otaka, Org. Lett. 2020, DOI:
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(295) “Synthetic hyperacetylation of nucleosomal histones” Hidetoshi Kajino, Tomomi Nagatani,
Miku Oi, Tomoya Kujirai, Hitoshi Kurumizaka, Atsuya Nishiyama, Makoto Nakanishi, Kenzo
Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai, RSC Chem. Biol. 2020, 1, 56–59.
(296) “Catalytic Allylation of Aldehydes Using Unactivated Alkenes” Shun Tanabe, Harunobu
Mitsunuma, Motomu Kanai, J. Am. Chem. Soc. 2020, 142, 12374−12381.
(297) "Photocatalytic redox-neutral hydroxyalkylation of N-heteroaromatics with aldehydes" Hiromu
Fuse, Hiroyasu Nakao, Yutaka Saga, Arisa Fukatsu, Mio Kondo, Shigeyuki Masaoka, Harunobu
Mitsunuma and Motomu Kanai, Chem. Sci. 2020, 11, 12206-12211.
(298) "Chromium-Catalyzed Linear-Selective Alkylation of Aldehydes with Alkenes" Yuki Hirao,
Yuri Katayama, Harunobu Mitsunuma and Motomu Kanai, Org. Lett 2020, 22, 8584-8588.
(299) "Integrating abiotic chemical catalysis and enzymatic catalysis in living cells" Christopher
Adamson and Motomu Kanai, Org. Biomol. Chem. 2021, 19, 37-45.
(300) "Chemical Insights into Liquid-Liquid Phase Separation in Molecular Biology" Yugo R.
Kamimura and Motomu Kanai, Bull. Chem. Soc. Jpn 2021, 94, 1045-1058.
(301) "POSOP", Kohei Fujiyoshi, Kenzo Yamatsugu and Motomu Kanai, Electronic Encyclopediaof Reagents for Organic Synthesis e-EROS 2021, Wiley.
(302) "Live-cell epigenome manipulation by synthetic histone acetylation catalyst system" Yusuke
Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka,
Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima and Motomu Kanai, Proc. Natl. Acad.
Sci. U.S.A. 2021, 118, e2019554118. DOI: 10.1073/pnas.2019554118(303) “Catalytic photooxygenation degrades brain Aβ in vivo” Nozomu Nagashima, Shuta Ozawa,
Masahiro Furuta, Miku Oi, Yukiko Hori, Taisuke Tomita, Yohei Sohma and Motomu Kanai Science
Advances 2021, 7, eabc9750. DOI: 10.1126/sciadv.abc9750(304) “Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in the brains of
Alzheimer’s disease model mice” Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi,
Takanobu Suzuki, Wenbo Wang, Yung Wen Chiu, Reiko Koike, Satoshi Yokoshima, Tohru
Fukuyama, Sho Takatori, Youhei Sohma, Motomu Kanai, and Taisuke Tomita Brain 2021, 144,
1884-1897.
(305) "Axially-substituted silicon phthalocyanine payloads for antibody-drug conjugates" Kazuki
Takahashi, Akira Sugiyama, Kei Ohkubo, Toshifumi Tatsumi, Tatsuhiko Kodama, Kenzo
Yamatsugu and Motomu Kanai Synlett 2021, 32, 1098-1103.
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(306) "A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with
Phosphoenolpyruvate Phosphodiester" Kohei Fujiyoshi, Shigehiro A Kawashima, Kenzo Yamatsugu
and Motomu Kanai Synlett 2021, 32, 1135-1140.
(307) "プロトン性官能基存在下での一価銅触媒による選択的結合形成反応" 金井 求, 有機
合成化学協会誌 2021, 79, 391-405.
(308) “Chemical Catalysis Intervening to Histone Epigenetics” Tamiko Nozaki and Motomu Kanai,Acc. Chem. Res. 2021, 54, 2313-2322.
(309) “Siloxy Esters as Traceless Activators of Carboxylic Acids: Boron-Catalyzed Chemoselective
Asymmetric Aldol Reaction” Taiki Fujita, Mina Yamane, W. M. C. Sameera, Harunobu
Mitsunuma, Motomu Kanai, Angew. Chem. Int. Ed. 2021, 60, 24598–24604.
(310) “A 4-hydroxyproline/trimethyl borate system for asymmetric synthesis of triple aldols fromdouble aldol cyclic hemiacetals” Yuki Hirao, Yamato Kanzaki, Harunobu Mitsunuma, Motomu
Kanai Tetrahedron 2021, 98, 132448.
(311) "Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis"
Christopher Adamson, Hidetoshi Kajino, Shigehiro A. Kawashima, Kenzo Yamatsugu, Motomu
Kanai J. Am. Chem. Soc. 2021, 143, 14976-14980.
(312) "Protein Modification at Tyrosine with Iminoxyl Radicals" Katsuya Maruyama, Takashi
Ishiyama, Yohei Seki, Kentaro Sakai, Takaya Togo, Kounosuke Oisaki, Motomu Kanai J. Am. Chem.
Soc. 2021, 143, 19844-19855.
(313) "Data-driven catalyst optimization for stereodivergent asymmetric synthesis by iridium/boron
hybrid catalysis" Hongyu Chen, Shigeru Yamaguchi, Yuya Morita, Hiroyasu Nakao, Xianging Zhai,
Yohei Shimizu, Harunobu Mitsunuma, Motomu Kanai Cell Reports Physical Sciences 2021, 2,
100679.
(314) “Chemical catalyst-promoted photooxygenation of amyloid proteins” Yohei Sohma, Taka
Sawazaki, Motomu Kanai Org. Biomol. Chem. 2021, 19, 10017-10029.
(315) “Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression andnon-covalent binding system” Kenzo Yamatsugu, Hiroto Katoh, Takefumi Yamashita, Kazuki
Takahashi, Sho Aki, Toshifumi Tatsumi, Yudai Kaneko, Takeshi Kawamura, Mai Miura, Masazumi
Ishii, Kei Ohkubo, Tsuyoshi Osawa, Tatsuhiko Kodama, Shumpei Ishikawa, Motomu Kanai, Akira
Sugiyama Protein Expression and Purification 2022, 192, 106043.
(316) “Knoevenagel Condensation between 2-Methyl-thiazolo [4, 5-b] pyrazines and Aldehydes”
Taka Sawazaki, Youhei Sohma, Motomu Kanai Chem. Pharm. Bull. 2022, 70, 82-84.
(317) “Titanium(IV) Chloride-Catalyzed Photoalkylation via C(sp3)−H Bond Activation of Alkanes”
Mina Yamane, Yamato Kanzaki, Harunobu Mitsunuma, Motomu Kanai Org. Lett. 2022, 24,
1486−1490.
(318) “Identification of a Self-Photosensitizing Hydrogen Atom Transfer Organocatalyst System”
Hiromu Fuse, Yu Irie, Masaaki Fuki, Yasuhiro Kobori, Kosaku Kato, Akira Yamakata, Masahiro
Higashi, Harunobu Mitsunuma, Motomu Kanai J. Am. Chem. Soc. 2022, 144, 6566–6574.
(319) “A Germanium Catalyst Accelerates the Photoredox α-C(sp3)–H Alkylation of Primary Amines”
Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai, Org. Lett. 2022, 24, 3325-3330.
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(320) “Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes
antitumor immunity” Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki,
Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura,
Tetsuya Sakurai, Teruki Honma, Takeshi Bamba, Masafumi Nakamura, Motomu Kanai, Makoto
Suematsu, Yoshinori Fukui Biochem. Biophys. Res. Commun. 2022, 609, 183-188.
(321) “Site-Selective α-Alkylation of 1, 3-Butanediol Using a Thiophosphoric Acid Hydrogen Atom
Transfer Catalyst” Hiroyasu Nakao, Harunobu Mitsunuma, Motomu Kanai Chem. Pharm. Bull. 2022,
70, 540-543.
(322) “Catalytic Alkylation of Ketones via sp3 C–H Bond Activation” Xue Peng, Yuki Hirao,
Shunsuke Yabu, Hirofumi Sato, Masahiro Higashi, Takuya Akai, Shigeyuki Masaoka, Harunobu
Mitsunuma, Motomu Kanai J. Org. Chem. 2022, (the Progress in Photocatalysis for Organic
Chemistry special issue)(323) “Activatable Iodinated BODIPYs for Selective Imaging and Photodynamic Disruption of
Amyloid Structures in Pathogenic Bacterial Biofilms” Joaquim Torra, Taka Sawazaki, Patricia
Bondia, Santi Nonell, Motomu Kanai, Youhei Sohma, Cristina Flors Sensors and Actuators B:
Chemical, 2022, 132475.
(324) “Linear-Selective Allylation of Aldehydes with Simple Alkenes Mediated by Quadruple
Hybrid Catalysis” Irie, Y.; Chen, H.; Fuse, H.; Mitsunuma, H.; Kanai, M. Adv. Synth. Catal. 2022,
364, 3378–3383.

Books(1) “Asymmetric Michael Reactions” in Catalytic Asymmetric Synthesis Motomu Kanai, Masakatsu
Shibasaki, Wiley-VCH (2000) I. Ojima Ed., pp. 569-592.
(2) “Rare earth bimetallic asymmetric catalysis” in Multimetallic Catalysts in Organic Synthesis
Motomu Kanai, Masakatsu Shibasaki (2004), 103-120.
(3) “Catalytic Asymmetric Total Synthesis of (–)-Strychnine and Fostriecin” in Strategies and Tactics
in Organic Synthesis Vol. 4, Elsevier, Masakatsu Shibasaki, Motomu Kanai, Takashi Ohshima 2004
年, pp. 347–363.
(4) “Nitroaldol Reaction” in Comprehensive Asymmetric Catalysis, Supplement 1 Springer, Berlin,
Masakatsu Shibasaki, Harald Gröger, Motomu Kanai, 2004 年, pp.131–133.
(5) 実験化学講座第５版：触媒化学、電気化学“医薬・農薬”柴崎正勝、金井求 2006 年、
pp. 77-88.
(6) 「抗インフルエンザ薬タミフルの純化学的合成」柴崎正勝、金井求 医学のあゆみ 2006
年、Vol. 219, No. 10, 781.
(7) 「タミフルの新合成法」柴崎正勝、金井求

化学と薬学の教室 2006 年、No.155, 33.

(8) “Chiral Bifunctional Acid/Base Catalysts” in New Frontiers in Asymmetric Catalysis Masakatsu
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Shibasaki and Motomu Kanai, Eds. Mikami, K. and Lautens, M. Wiley Interscience, 2007.
(9) 「タミフル実用合成への道－切れのある合成を目指して－」柴崎正勝、金井求、山次健
三、現代科学 2009 年 1 月号、454, pp 38-43.
(10) “The Catalytic Asymmetric Strecker Reaction” Shibasaki, M.; Kanai, M.; Mita, T. Org. React.
2008, 70, 1-117.
(11) 「インフルエンザパンデミックに備える－科学者の使命－」柴崎正勝、金井求、化学と工業 2009, 62, 22-24.
(12) “Catalytic Enantioselective Synthesis of α,α-Disubstituted Amino Acids: The Strecker Reactionof Ketimines Using Chiral Poly-Gadolinium Complexes” Shibasaki, M.; Kanai, M. in Asymmetric
Synthesis and Application of α-Amino Acids, Editors: Vadim A. Soloshonok, Kunisuke Izawa, ACS
Symposium Series, Volume 1009, 2009, Chapter 7, pp. 102–115.
(13) “Recent Topics in Cooperative Catalysis: Asymmetric Catalysis, Polymerization, Hydrogen
Activation, and Water Splitting” Kanai, M. in Organic Chemistry–Breakthroughs and Perspectives,
Editors: Kuiling Ding and Li-Xin Dai, Wiley-VCH, 2012, Chapter 11, pp. 385–412.
(14) 「銅触媒の多様な活性化形式を活用する反応開発と医薬リード合成」”Noble Catalytic
Functions by Ubiquitous Copper Complexes: Asymmetric Catalysis to Oxidative Coupling” 嵯峨裕、金井求、「未来を拓く元素戦略－持続可能な社会を実現する化学－」日本化学会編、
化学同人 2013 年(15) “Site-Selective Peptide/Protein Cleavage” Jizhi Ni, Motomu Kanai in Site-Selective Catalysis,
Topics in Current Chemistry, Editor: Takeo Kawabata, Springer Berlin Heidelberg, 2015, DOI:
10.1007/128_2015_652.
(16) “Catalytic asymmetric addition reactions of Cu(I)-conjugated soft carbon nucleophiles”
Xiaofeng Wei, Yohei Shimizu and Motomu Kanai, in Progress in enantioselective Cu(I)-catalyzed
formation of stereogenic centers, Topics in Organometallic Chemistry, Editor: Syuzanna
Harutyunyan, Springer 2016, Vol. 58, Chapter 5, pp. 169-182, DOI: 10.1007/3418_2015_163.
(17) 「無保護糖の直接変換を可能とする触媒開発」清水洋平、金井求、JACI News Letter 2016,
No. 58, p.7.
(18)「金属触媒と有機分子触媒の違い」小島正寛、金井求 有機分子触媒の化学～モノづく
りのパラダイムシフト 日本化学会 編、2016 年、 CSJ Current Review, pp. 30-35.
(19) “Chemical Catalyst-Mediated Selective Photo-oxygenation of Pathogenic Amyloids” Youhei
Sohma, Motomu Kanai, Handbook of In Vivo Chemistry in Mice: From Lab to Living System 2020,
Eds. Katsunori Tanaka, Kenward Vong, Wiley-VCH, pp 355-371.
(20) "Chemical catalyst-promoted regioselective histone acylation" Yuki Yamanashi, Motomu Kanai,
Supramolecular Catalysis: New Directions and Developments 2021, Wiley.

26

(21) "化学触媒による合成的エピジェネティクス" 山次 健三, 金井 求, 化学 2021, 76, 12.
(22) "エピゲノム操作が可能なヒストンアシル化触媒の開発" 川島 茂裕, 金井 求, ファル
マシア 2021, 57, 810-814.
(23) 「光触媒／ラジカル触媒／金属錯体触媒の３成分ハイブリッドによる炭化水素の水素放出反応および炭素－炭素結合形成反応」三ツ沼治信、金井求 有機光反応の化学～光が誘起する電子移動・触媒系・有機合成 日本化学会 編、2022 年、CSJ Current Review, pp.
94-103.
(24) 「触媒医療に向けた細胞や個体で機能する化学触媒」岩井篤志、幅﨑美涼、金井求
中有機合成の開発動向 シーエムシー出版、2022 年、ファインケミカルシリーズ

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