A cosmetic product shows brightening/whitening effect after
4 weeks under normal conditions of use, in adult females withfacial hyperpigmentation
Corinne Granger, Palmira Valderas-Martinez, Javier Bustos, Aurora GarreLaboratorios ISDIN, S.A.; Innovation and Development, Barcelona, Spain

RESULTS
After 4 weeks of use the product reduced significantly theappearance of spots and improve the skin homogeneity analyzed
by Visioface (Figure 2 and Table 1).

Participants reported high level ofsatisfaction with the results after 4weeks of use (Figure 3).
Self-assessment questionarie results

My skin seems healthierMy skin is soothed
My skin is smoother
The product refines skin texture
Figure 3

INTRODUCTION & OBJECTIVES
Photoaging leading hyperpigmentary disorders and uneven skintone is a major cosmetic concern as even-toned skin is universally
associated with healthy skin. Current treatments for pigmentary
disorders include drugs such as hydroquinone or topical steroids
which often produce undesired side effects and are not suitable forall skin types. For that reason, skin care specialists are looking forlong-term cosmetic products to address such concerns. We
conducted a study to assess the tolerability and whitening
effectiveness of a cosmetic product containing ingredients withskin whitening activity like Niacinamide, Hydroxyphenoxy Propionic
Acid and 4-n-Butylresorcinol.

The product leaves the skin more hydrated
The product helps to fade brown spots on the skin
The product withens the skin
The product has depigmenting effect

MATERIALS & METHODS
D0
Product use: Twice daily (morning and night)

The product evens out the skin tone

D28

The product minimizes dark spots
The product minimizes the appearance of colour imperfections

Figure 2: Visioface images

Figure 133 female> 1 measurable
pigmented spot

ClinicalScoring byDermatologist

D28Assessments- Color intensity ofthe pigmented spot
- Complexion
homogeneity

Instrumental- Visioface images

SubjectiveQuestionnaire- Cosmetic Qualities- Product Efficacy- Skin brightness- Skin luminosity- Overall moisturising
aspectFigure 1. Study design

Statistical analysis was performed by Repeated Measurement
ANOVA and results were considered significant at p<0.05.

%Variation

p-value

Spots-10%< 0.001

Skin homogeneity+10%< 0.0001

Table 1. Visioface analysisMoreover, several clinical evaluations show statistical improvement(Table 2).

Table 2

D0

Table 1The product minimizes the size of colour imperfections%Variation

p-value

Colour intensity of the pigmented spot

-10%

0.0039Complexion homogeneity+17%0.0001Skin brightness+12%0.0002Skin luminosity+15%< 0.0001

Overall appearance of moisturized skin+34%< 0.0001

Table 2. Clinical evaluation

50%

60%

70%

80%

90%

100%

Figure 3: Results of the subjective questionnaire done by the volunteers after 28 days of use.

Cutaneous acceptability of the investigational product wasconsidered as good.
CONCLUSIONS
Significant improvement of skin complexion and reduction of theskin hyperpigmentation linked to photoaging suggests that thecosmetic product containing ingredients like Niacinamide,
Hydroxyphenoxy Propionic Acid and 4-n-Butylresorcinol, could beconsidered effective after 4 weeks of treatment. The tolerance ofthe product was good.
References

Ohad N. Glabrene and Isoliquiritigenin as Tyrosinase Inhibitors from Licorice
Roots. J. Agric. Food Chem. 2003, 51, 1201-1207
Hakozaki T. The effect of niacinamide on reducing cutaneous pigmentation andsuppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31.

27th EADV Congress. France, Paris. 12-16 September 2018
© 2018 ISDIN S.A.