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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023
Date of issue for the 1st edition : 20/Jul/2017
Date of revision : 25/Jul/2023

Safety Data Sheet

Section 1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Benzene
Reference number(SDS):68155jis_J_E2-2
Product type：
Reagent
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

Section 2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
PHYSICAL AND CHEMICAL HAZARDS
Flammable liquids: Category 2
HEALTH HAZARDS
Acute toxicity (Oral): Category 4
Skin corrosion/irritation: Category 2
Serious eye damage/eye irritation: Category 2AGerm cell mutagenicity: Category 2
Carcinogenicity: Category 1A
Reproductive toxicity: Category 2
Specific target organ toxicity - single exposure: Category 1 (respiratory system)
Specific target organ toxicity - single exposure: Category 3 (Narcotic effects)
Specific target organ toxicity - repeated exposure: Category 1 (central nervous system, hematopoietic
system)Aspiration hazard: Category 1
ENVIRONMENT HAZARDS
Hazardous to the aquatic environment, short-term (acute): Category 2
Hazardous to the aquatic environment, long-term (chronic): Category 2(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H225-Highly flammable liquid and vapor
H302-Harmful if swallowed
H315-Causes skin irritation
H319-Causes serious eye irritation
H341-Suspected of causing genetic defects
H350-May cause cancer

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H361-Suspected of damaging fertility or the unborn child
H370-Causes damage to organs
H336-May cause drowsiness or dizzinessH372-Causes damage to organs through prolonged or repeated exposure
H304-May be fatal if swallowed and enters airways
H401-Toxic to aquatic life
H411-Toxic to aquatic life with long lasting effects
PRECAUTIONARY STATEMENT
Prevention
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Avoid release to the environment.
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
Do not breathe dust/fume/gas/mist/vapors/spray.
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
In case of fire: Use water mist, foam, dry powder, CO2 to extinguish.
Collect spillage.
Get medical advice/attention if you feel unwell.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF exposed or concerned: Call a POISON CENTER/doctor/physician.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
Rinse mouth. Do NOT induce vomiting.
IF SWALLOWED: Immediately call a POISON CENTER/doctor/physician.
IF SWALLOWED: Call a POISON CENTER/doctor/physician if you feel unwell.
Storage
Store in a well-ventilated place. Keep container tightly closed. Keep cool.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.
Specific Physical and Chemical hazards
Highly flammable liquid. Vapor/air mixture may explode.

Section 3. Composition/information on ingredients
Mixture/Substance selection:
Substance

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023
Ingredient name:Benzene
Content (%):99.5 <Chemical formula:C6H6
Chemicals No, Japan:3-1
CAS No.:71-43-2
MW:78.11
ECNO:200-753-7
Note : The figures shown above are not the specifications of the product.

Section 4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
Keep victim warm and quiet.
Call emergency medical service.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Give artificial respiration if victim is not breathing.
Administer oxygen if breathing is difficult.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
Wash with plenty of soap and water.
If skin irritation or rash occurs: Get medical advice/attention.
If skin irritation occurs: Get medical advice/attention.
In case of burns, immediately cool affected skin for as long as possible with cｈild water.
Do not remove clothing if adhering to skin.
Remove and isolate contaminated clothing and shoes.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth. Do NOT induce vomiting.
Immediately call a POISON CENTER/doctor/physician.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayed(Symptoms when inhalation or ingestion)
Nausea. Abdominal pain. Headache. Drowsiness. Dizziness. Shortness of breath.
Convulsions. Unconsciousness. Sore throat. Vomiting.
(Symptoms when skin and/or eye contact)
Dry skin. Conjunctival redness of the eyes. Redness of the skin. Pain.
Indication of any immediate medical attention and special treatment needed
Ensure that medical personnel are aware of the material(s) involved, and take precautions
to protect themselves.

Section 5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use water mist, foam, dry powder, CO2 to extinguish.

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Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with a full facepiece operated
in the positive pressure mode.

Section 6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Keep unauthorized personnel away.
In case of contact with substance, immediately flush skin or eyes with running water for atleast 20 minutes.
Ventilate area until material pick up is complete.
Wear proper protective equipment.
PUBLIC SAFTY: Ventilate closed spaces before entering.
Do not touch or walk through spilled material.
Environmental precautions
Runoff to sewer may create fire or explosion hazard.
Vapor explosion hazard indoors, outdoors or in sewers.
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean non-sparking tools to collect absorbed material.
All equipment used when handling the product must be grounded.
Preventive measures for secondary accident
Collect spillage.
Stop leak if you can do it without risk.
ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
Prevent entry into waterways, sewers, basements or confined areas.
A vapor suppressing foam may be used to reduce vapors.
Keep out of low areas.

Section 7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong acids, Oxidizing agents, Halogens should not be mixed with the chemicals.
Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
Take off contaminated clothing and wash it before reuse.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed. Keep cool.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

Section 8. Exposure controls/personal protection
Control parameters
Control value
Japan control value (2004) <= 1ppm
Adopted value
JSOH(1997) (Individual excess lifetime risk of cancer: 10E-3) Reference value: 1ppm;(Individual excess lifetime risk of cancer: 10E-4) Reference value: 0.1ppm
ACGIH(1997) TWA: (0.5ppm);
STEL: (2.5ppm) (Leukemia)
Notation…Skin
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Wear positive pressure self-contained breathing apparatus (SCBA).
Hand protection
Wear protective gloves. Recommended material(s): viton
Inspect before use and replace worn or damaged gloves.
Contact the glove manufacturer for specific advice on glove selection and breakthroughtimes for your use conditions.

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.

Section 9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Liquid
Color: Colorless-clear
Odor: Characteristic odor
Odor threshold: 4.68ppm
Melting point/Freezing point: 6℃
Boiling point or initial boiling point: 80℃
Boiling range data is not available.
Flammability (gases, liquids and solids): Ignitable
Lower and upper explosion limit/flammability limit:
Lower explosion limit: 1.2 vol %Upper explosion limit: 8.0 vol %Flash point: (c.c.)-11℃
Auto-ignition temperature: 498℃
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity: 0.604mPas(25℃)
Kinematic viscosity: 0.69mm2/s(25℃)
Solubility:
Solubility in water: 0.18g/100 ml（25℃）
Solubility in solvent: Very soluble in ethanol and diethyl ether.
n-Octanol/water partition coefficient: log Pow2.13
Vapor pressure: 10kPa（20℃）
Density and/or relative density: 0.88g/cm3(20℃)
Relative vapor density (Air=1): 2.7
Relative density of the Vapor/air - mixture at 20℃ (Air = 1): 1.2
Particle characteristics data is not available.
Other information
Critical temperature: 288.9℃
Evaporation rate data is not available.
VOC data is not available.

Section 10. Stability and Reactivity
Reactivity
Reactivity data is not available.
Chemical stability
Stable under normal storage/handling conditions.
Highly flammable.
Possibility of hazardous reactions
The vapour is heavier than air and may travel along the ground; distant ignition possible.
As a result of flow, agitation, etc., electrostatic charges can be generated.
Reacts violently with oxidants, nitric acid, sulfuric acid and halogens. This generates
fire and explosion hazard.
Attacks plastics (e.g. polyvinyl chloride) and rubber(e.g. natural rubber, nitrile rubber and butyl rubber).

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Conditions to avoid
Contact with incompatible materials.
Open flames. Heating. Sparks.
Incompatible materials
Strong acids, Oxidizing agents, Halogens.
Hazardous decomposition products
Carbon oxides

Section 11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[Product]Category 4, Harmful if swallowed[Data for components of the product][GHS Cat. Japan, base data]
rat LD50＝1620mg/kg (calcd.)
Acute toxicity (Dermal)[Product]
Based on available data, the classification criteria are not met.
[Data for components of the product][GHS Cat. Japan, base data]
rabbit LD50>=8200 mg/kg（NICNAS, 2001）
Acute toxicity (Inhalation)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product][GHS Cat. Japan, base data]
vapor : rat LC50＝44.66 mg/L/4hr（EHC 150, 1993）
Irritant properties
Skin corrosion/irritation[Product]Category 2, Causes skin irritation[Data for components of the product][GHS Cat. Japan, base data]
rabbit : irritation (NICNAS, 2001 et al)
Serious eye damage/irritation[Product]Category 2A, Causes serious eye irritation[Data for components of the product][GHS Cat. Japan, base data]
rabbit : moderate eyes irritation (NICNAS, 2001 et al)
Sensitization
Respiratory sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Skin sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023
Germ cell mutagenicity[Product]Category 2, Suspected of causing genetic defects[Data for components of the product][GHS Cat. Japan, base data]
cat. 2; EHC 150, 1993
Carcinogenicity[Product]Category 1A, May cause cancer[Data for components of the product][GHS Cat. Japan, base data]
cat.1A; IARC Gr.1 (IARC, 1987 et al.)[IARC]
Group 1 : Carcinogenic to humans[ACGIH]
A1(1997) : Confirmed Human Carcinogen[JSOH]
Group 1: The agents which are carcinogenic to humans[NTP]
Known : Known to be Human Carcinogens[NTP]
K/L; Known/likely human carcinogen(1996)[EU]
Category 1A; Substances known to have carcinogenic potential for humans
Reproductive toxicity[Product]Category 2, Suspected of damaging fertility or the unborn child[Data for components of the product][GHS Cat. Japan, base data]
cat. 2; ATSDR, 2005
Specific target organ toxicity (STOT)
STOT-single exposure[Product]Category 1, Causes damage to organs
Category 3, May cause drowsiness or dizziness[Data for components of the product][cat.1][GHS Cat. Japan, base data]
respiratory system (NICNAS, 2001)[cat.3 (narcotic effects)][GHS Cat. Japan, base data](Benzene)narcotic effect (EHC 150, 1993)
STOT-repeated exposure[Product]Category 1, Causes damage to organs through prolonged or repeated exposure[Data for components of the product][cat.1][GHS Cat. Japan, base data]
hematopoietic system, central nervous system (NICNAS, 2001)
Aspiration hazard[Product]Category 1, May be fatal if swallowed and enters airways

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023[Data for components of the product][cat.1][GHS Cat. Japan, base data]
cat. 1; hydrocarbon, kinematic viscosity =0.740 mm2/s (25℃)

Section 12. Ecological Information
Toxicity
Aquatic toxicity[Product]Category 2, Toxic to aquatic life
Category 2, Toxic to aquatic life with long lasting effects[Data for components of the product]
Hazardous to the aquatic environment, short-term (acute)[GHS Cat. Japan, base data]
Fish (rainbow trout) LC50=5.3mg/L/96hr (EU-RAR, 2008)
Hazardous to the aquatic environment, long-term (chronic)[GHS Cat. Japan, base data]
Fish (Pimephales promelas) NOEC=0.8mg/L/32hr (EU-RAR, 2008)
Water solubility[Data for components of the product]
0.18 g/100 ml (25℃) (ICSC, 2016)
Persistence and degradability[Data for components of the product]
Not rapidly degradable [BOD_Degradation: 40% (METI existing chemical safety inspections, 1979)]
Bioaccumulative potential[Data for components of the product]log Pow=2.13 (ICSC, 2016)
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

Section 13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Avoid release to the environment.
Dispose of contents/container in accordance with local/national regulation.

Section 14. Transport Information
UN No., UN CLASS
UN Number or ID Number : 1114
UN Proper Shipping Name : BENZENEClass or division (Transport hazard class) : 3
Packing group : II
ERG GUIDE No.: 130
IMDG Code (International Maritime Dangerous Goods Regulations)
UN Number or ID Number : 1114
UN Proper Shipping Name : BENZENEClass or division (Transport hazard class) : 3
Packing group : II

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Benzene,JUNSEI CHEMICAL CO., LTD.,68155jis_J_E2-2,25/Jul/2023
IATA (Dangerous Goods Regulations)
UN Number or ID Number : 1114
UN Proper Shipping Name : BENZENEClass or division (Transport hazard class) : 3
Hazard labels : Flamm.liquid
Packing group : II
Environmental hazards
Marine pollutants (yes/no) : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Noxious Liquid Substances ; Cat. Y
BenzeneFlammable Liquid
Benzene
MARPOL Annex V - HME (Harmful to the Marine Environment)
Carcinogenicity: cat.1, 1A, 1B
BenzeneSpecific target organ toxicity - repeated exposure: cat.1
BenzeneHazardous to the aquatic environment - long-term (chronic): cat.1, 2
BenzeneSection 15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
Labor Standards Act, Japan
Chemical substances or compounds (including alloys) causing disease (Regulation, Appended Table1-2-4-1)
BenzeneCarcinogen (Regulation, Appended Table 1-2-7)
BenzeneU.S. Toxic Substances Control Act (TSCA) Inventory
Chemicals listed in TSCA Inventory
71-43-2
All components are listed or exempted.
Superfund Amendments and Reauthorizations Act (SARA), Title III
SARA 313 (TRI)
BenzeneOther regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by yourresponsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informedby supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

Section 16. Other information
GHS classification and labelling
H225-Flammable liquids, Category 2: H225 Highly flammable liquid and vapour

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H302-Acute toxicity, Category 4: H302 Harmful if swallowed
H315-Skin corrosion/irritation, Category 2: H315 Causes skin irritation
H319-Serious eye damage/eye irritation, Category 2A: H319 Causes serious eye irritation
H341-Germ cell mutagenicity, Category 2: H341 Suspected of causing genetic defects
H350-Carcinogenicity, Category 1A: H350 May cause cancer
H361-Reproductive toxicity, Category 2: H361 Suspected of damaging fertility or the unbornchild
H370-STOT - single exposure, Category 1: H370 Causes damage to organs
H336-STOT - single exposure, Category 3, Narcotic effects: H336 May cause drowsiness ordizziness.
H372-STOT - Repeated exposure, Category 1: H372 Causes damage to organs through prolonged
or repeated exposure
H304-Aspiration hazard, Category 1: H304 May be fatal if swallowed and enters airways
H401-Hazardous to the aquatic environment, short-term (acute), Category 2: H401 Toxic toaquatic life
H411-Hazardous to the aquatic environment, long-term (chronic), Category 2: H411 Toxic toaquatic life with long lasting effects
References and sources for data
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 22nd edit., 2021 UN
IMDG Code, 2020 Edition (Incorporating Amendment 40-20)
IATA Dangerous Goods Regulations (64th Edition) 2023
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2023 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192022 Recommendation on TLVs (JSOH)
Notification No. 0111-1 (January 11, 2022), Chemical Hazards Control Division, Industrial
Safety and Health Department, Labour Standards Bureau, MHLW in Japan
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.24
(https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020,
METI)
Abbreviations and acronyms
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)

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JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of this
Safety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2021).