Appendix 1-4

List of Publications FY 2018
A. WPI papers
1. Original Articles
1) Nakamura Y, Matsuzaka, T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A(2018) Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation. Cell
Death & Disease 9:1181. doi:10.1038/s41419-018-1226-1

2) Bjorness TE, Greene RW (2018) Sleep deprivation alters the time course but not magnitude oflocomotor sensitization to cocaine. Sci Rep. 8:17672. doi:10.1038/s41598-018-36002-1

3) Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Mishima K, Honda M, Tokunaga K et al. (2018) A variant
at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia. J. Hum. Genet.
63(12):1259-1267 doi:10.1038/s10038-018-0518-8

4) Saito YC, Tsujino N, Abe M, Yamazaki M, Sakimura K, Sakurai T (2018) Serotonergic Input to Orexin

Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture. Front Neurosci. 12:892
doi:10.3389/fnins.2018.00892

5) Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M (2018) Sleep
and Wakefulness Are Controlled by Ventral Medial Midbrain/Pons GABAergic Neurons in Mice. J
Neurosci. 38(47):10080-10092. doi:10.1523/JNEUROSCI.0598-18.2018

6) Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa H, Takahashi S, Ema M (2018) Klf5
suppresses ERK signaling in mouse pluripotent stem cells. PLoS One 13(11):e0207321
doi:10.1371/journal.pone.0207321

7) Saitoh A, Soda A, Kayashima S, Yoshizawa K, Oka JI, Nagase H, Yamada M (2018) A delta opioid
receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate
transporter blocker-induced anxiety-like behavior in mice. J Pharmacol Sci. 138(3):176-183.
doi:10.1016/j.jphs.2018.09.009

8) Kaushik MK, AritakeK, Cherasse Y, Sharma R, Urade Y (2018) A gain-of-function study of ameliorationof pentylenetetrazole-induced seizures by endogenous prostaglandin D-2 Neurosci Lett. 686:140-144.
doi:10.1016/j.neulet.2018.09.011

9) Kutsumura N, Nagase H (2018) Unique Reactions of Morphinan Skeletons and Conversions of the
Skeletons to Active Alkaloids. J Syn Org Chem Jpn. [Japanese: 有機合成化学協会誌] 76(9):914-921.
doi:10.5059/yukigoseikyokaishi.76.914

10) Kutsumura N, Okada T, Imaide S, Fujii H, Nagase H (2018) Acetic Anhydride Mediated Retro-Ene

Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage.
Synthesis-Stuttgart 50(21):4263-4269. 10.1055/s-0036-1589138

11) Zhang Y, Sugai T, Yamamoto T, Yamamoto, N, Kutsumura N, Nishiyama S, Einaga Y, Saitoh, T, Nagase H(2018) Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide
Anions. ChemElectroChem. 5. 10.1002/celc.201801308.

12) Kuwano N, Kato, TA, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N,
Kubo H, Sakurai T, Kanba S (2018) Neuron-related blood inflammatory markers as an objective
evaluation tool for major depressive disorder: An exploratory pilot case-control study. J Affect
Disorders. 240:88-98. doi:10.1016/j.jad.2018.07.040
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Appendix 1-413) Murata K, Lu WZ, Hashimoto M, Ono N, Muratani M, Nishikata K, Kim JD, Ebihara S, Ishida J, Fukamizu
A (2018) PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals
Cryptic Alternative Splicing Products. iScience. 8:200-+. doi:10.1016/j.isci.2018.09.023

14) Sakikubo M, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, Goto T, Hirata K, Masui T, Dor
Y, Fujiyama T, Hoshino M, Uemoto S, Kawaguchi Y (2018) Ptf1a inactivation in adult pancreatic acinar
cells causes apoptosis through activation of the endoplasmic reticulum stress pathway. Sci Rep.
8:15812. doi:10.1038/s41598-018-34093-4

15) Cherasse Y, Aritake K, Oishi Y, Kaushik MK, Korkutata M, Urade Y (2018) The Leptomeninges Produce
Prostaglandin D-2 Involved in Sleep Regulation in Mice. Front Cell Neurosci. 12:357.
doi:10.3389/fncel.2018.00357

16) Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi
S, Funato H, Yanagisawa M (2018) A single phosphorylation site of SIK3 regulates daily sleep amounts
and sleep need in mice Proc Natl Acad Sci USA. 115(41):10458-10463. doi:10.1073/pnas.1810823115

17) Sugiyama, A, Yamada M, Saitoh A, Nagase H, Oka JI, Yamada M (2018) Administration of a delta opioid
receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats.
Psychopharmacology. 235(10):2947-2955. doi:10.1007/s00213-018-4984-7

18) Kulathunga K, Hamada M, Hiraishi Y, Otake M, Tran MTN, Cheng O, Tanaka J, Sakasai T, Sakaguchi S,
Sugiyama Y, Fleischmann BK, Takahashi S, Miwa Y (2018) A Novel iRFP-Incorporated in vivo Murine
Atherosclerosis Imaging System. Sci Rep. 8:14515. doi: 10.1038/s41598-018-32456-5

19) Kutsumura N, Kiriseko A, Niwa K, Saito T (2018) Total Syntheses of 3-epi-Litsenolide D-2 andLincomolide A. J Org Chem. 83(18):11450-11457. doi:10.1021/acs.joc.8b01825

20) Mochizuki A, Nakayama K, Nakamura S, Dantsuji M, Kamijo R, Shioda S, Sakurai T, Ozeki M, Inoue T(2018) Involvement of orexin in lipid accumulation in the liver. J Oral Sci. 60(3):76-82.
doi:10.1016/j.job.2018.07.001

21) Takaya D, Inaka K, Omura, A, Takenuki K, Kawanishi M, Yabuki Y, Nakagawa Y, Tsuganezawa K, Ogawa
N, Watanabe C, Honma T, Aritake K, Urade Y, Shirouzu M, Tanaka A (2018) Characterization of crystal
water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex byinteraction energy studies. Bioorgan Med Chem. 26(16):4726-4734. doi:10.1016/j.bmc.2018.08.014

22) Niwa Y, Kanda GN, Yamada RG, Shi S, Sunagawa GA, Ukai-Tadenuma M, Fujishima H, Matsumoto N,

Masumoto K, Nagano M, Kasukawa T, Galloway J, Perrin D, Shigeyoshi Y, Ukai H, Kiyonari H, Sumiyama
K, Ueda HR (2018) Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Cell Reports. 24(9):2231. doi:10.1016/j.celrep.2018.07.082

23) Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M (2018)

Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response.
Front Neurosci. 12:535. doi:10.3389/fnins.2018.00535

24) Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa
A, Kitaoka S, Sawas A, Narumiya S, Furuyashiki T (2018) Dopamine D1 receptor subtype mediates
acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex andcontributes to suppression of stress susceptibility in mice. Mol Psychiatry. 23(8):1717-1730.
doi:10.1038/mp.2017.177

25) Sato Y, Tsukaguchi H, Takahashi S, Yoshimura A et al. (2018) A mutation in transcription factor MAFB
causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome. Kidney Int. 94(2):396407. doi:10.1016/j.kint.2018.02.025
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Appendix 1-4

26) Yoshida S, Ohnishi R, Tsuneoka Y, Yamamoto-Mimura Y, Muramatsu R, Kato T, Funato H, Kuroda KO(2018) Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal
Absence-Induced Attenuation of Transport Response in Mouse Pups. Front Cell Neurosci. 12:204.
doi:10.3389/fncel.2018.00204

27) Saito YC, Maejima T, Nishitani M, Hasegawa E, Yanagawa Y, Mieda M, Sakurai T (2018) Monoamines

Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections toHypothalamic Arousal Neurons. J Neurosci. 38(28):6366-6378. doi:10.1523/JNEUROSCI.2835-17.2018

28) Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa
T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima Y,
Yanagisawa M, Funato H, Hoshino M (2018) Forebrain Ptf1a Is Required for Sexual Differentiation of
the Brain. Cell Reports 24(1):79-94. doi:10.1016/j.celrep.2018.06.010

29) Araki M, Nakagawa Y, Oishi A, Han S, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M,
Matsuzaka T, Shimano H (2018) The Peroxisome Proliferator-Activated Receptor alpha (PPAR
alpha)Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 19(7):2148.
doi:10.3390/ijms19072148

30) Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N,

Shimano H (2018) Malondialdehyde-modified LDL-related variables are associated with diabetic kidneydisease in type 2 diabetes. Diabetes Res Clin Pract. 141:237-243. doi:10.1016/j.diabres.2018.05.019

31) Wang ZQ, Ma J, Miyoshi C, Lie YX, Sato M, Ogawa Y, Lou TT, Ma CY, Gao X, Lee C, Fujiyama T, Yang XJ,
Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao LQ, Takahashi S,
Peng JM, Yu YH, Funato H, Yanagisawa M, Liu QH (2018) Quantitative phosphoproteomic analysis of
the molecular substrates of sleep need. Nature. 558(7710):435-439. doi:10.1038/s41586-018-0218-8

32) Yajima K, Iwayama K, Ogata H, Park I, Tokuyama K (2018) Meal rich in rapeseed oil increases 24-h fat
oxidation more than meal rich in palm oil. PLoS One. 13(6):e0198858.
doi:10.1371/journal.pone.0198858

33) Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M (2018)
Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy. Proc Natl
Acad Sci USA. 23:6046-6051. doi:10.1073/pnas.1722686115

34) Schoonakker M, Meijer JH, Deboer T, Fifel K (2018) Heterogeneity in the circadian and homeostatic
modulation of multiunit activity in the lateral hypothalamus. Sleep. 41(6): zsy051.
doi:10.1093/sleep/zsy051

35) Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han S, Takeuchi Y, Aita Y,

Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano
H (2018) Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy andExacerbate Insulin Resistance. Endocrinology. 159(6):2308-2323. doi:10.1210/en.2017-03179

36) Oda S, Tsuneoka Y, Yoshida S, Adachi-Akahane S, Ito M, Kuroda M, Funato H (2018)

Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex. J Comp Neurol.
526(8):1329-1350. doi:10.1002/cne.24409

37) Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM (2018) Genetic

Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing
Basal Forebrain Neurons in Behavioral State Control. J Neurosci. 38(22):5168-5181.
doi:10.1523/JNEUROSCI.2955-17.2018

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Appendix 1-438) Honjoh S, Sasai S, Schiereck SS, Nagai H, Tononi G, Cirelli C (2018) Regulation of cortical activity andarousal by the matrix cells of the ventromedial thalamic nucleus. Nat Commun. 9:2100.
doi:10.1038/s41467-018-04497-x

39) Bjorness TE, Greene RW (2018) Dose response of acute cocaine on sleep/waking behavior in mice.
Neurobiol Sleep Circadian Rhythms. 5:84-93. doi:10.1016/j.nbscr.2018.02.001

40) Wang YB, Cao LQ, Lee CY, Matsuo T, Wu KJ, Asher G, Tang LJ, Saitoh T, Russell J, Klewe-Nebenius D,

Wang L, Soya S, Hasegawa E, Cherasse Y, Zhou JM, Li YWB, Wang T, Zhan XW, Miyoshi C, Irukayama Y,
Cao J, Meeks JP, Gautron L, Wang ZQ, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H,
Kobayakawa R, Kobayakawa K, Beutler B, Liu QH (2018) Large-scale forward genetics screening
identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun.
9:2041. doi:10.1038/s41467-018-04324-3

41) Fifel K, Meijer JH, Deboer T (2018) Circadian and Homeostatic Modulation of Multi-Unit Activity in
Midbrain Dopaminergic Structures. Sci Rep. 8:7765. doi:10.1038/s41598-018-25770-542) Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T,
Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H (2018) Molecular association model of PPAR
alpha and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARM alpha.
Biochem Biophys Res Commun. 499(2):239-245. doi:10.1016/j.bbrc.2018.03.135

43) Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, Kokubo T, Kurokawa T (2018) Fc

engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS One.
13(5):e0196422. doi:10.1371/journal.pone.0196422

44) Toyama S, Shimoyama N, Tagaito Y, Nagase H, Saitoh T, Yanagisawa M, Shimoyama M (2018)
Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats.
Anesthesiology. 128(5):992-1003. doi:10.1097/ALN0000000000002161

45) Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B (2018)
Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology. 133:395-403.
doi:10.1016/j.neuropharm.2018.02.010

46) Luo YJ, Li YD, Wang L, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, Huang ZL(2018) Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine
D-1 receptors. Nat Commun. 9:1576. doi:10.1038/s41467-018-03889-3

47) Yang SR, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DR, Yuan XS, Ye CB, Guo W,
Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL (2018) The rostromedial tegmental nucleus isessential for non-rapid eye movement sleep. PLOS Biol. 16(4): e2002909.
doi:10.1371/journal.pbio.2002909

48) Katoh MC, Jung YS, Ugboma CM, Shimbo M, Kuno A, Basha WA, Kudo T, Oishi H, Takahashi S (2018)

MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic alpha Cells In Vivo. Mol Cell
Biol. 38(8): e00504-17. doi:10.1128/MCB.00504-17

49) Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H (2018)
Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice.
Pharmacol Rep. 70(2):350-354. doi:10.1016/j.pharep.2017.08.018

50) Monma T, Ando A, Asanuma T, Yoshitake Y, Yoshida G, Miyazawa T, Ebine N, Takeda S, Omi N, Satoh
M, Tokuyama K, Takeda F (2018) Sleep disorder risk factors among student athletes. Sleep Med.
44(76):76-81. doi:10.1016/j.sleep.2017.11.1130

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Appendix 1-451) Yamamoto T, Akahori M, Natsui K, Saitoh T, Einaga Y (2018) Controlled decoration of boron-doped
diamond electrodes by electrochemical click reaction (e-CLICK). Carbon. 130:350-354.
doi:10.1016/j.carbon.2017.12.098

52) Kitada N, Saitoh T, Ikeda Y, Iwano S, Obata R, Niwa H, Hirano T, Miyawaki A, Suzuki K, Nishiyama S,

Maki SA (2018) Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of
firefly luciferin analogues by allyl substitution. Tetrahedron Lett. 59(12)1087-1090.
doi:10.1016/j.tetlet.2018.01.078

53) Yamamoto T, Riehl B, Naba, K, Nakahara K, Wiebe A, Saitoh T, Waldvogel SR, Einaga Y (2018) A
solvent-directed stereoselective and electrocatalytic synthesis of diisoeugenol. Chem Commun
54(22):2771-2773. doi:10.1039/c8cc00794b

54) Kutsumura N, Koyama Y, Suzuki Y, Tominaga K, Yarnarnoto N, Saitoh T, Nagumo Y, Nagase H (2018)
Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton. Org Lett. 20(6):1559-1562.
doi:10.1021/acs.orglett.8b00288

55) Kaida K, Abe T (2018) Attentional lapses are reduced by repeated stimuli having own-name during amonotonous task. PLoS One. 13(3): e0194065. doi:10.1371/journal.pone.0194065

56) Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H,

Satoh T, Fukamizu A, Funato H, Yanagisawa M (2018) Sleep/Wake Behaviors in Mice During Pregnancy
and Pregnancy-Associated Hypertensive Mice. Sleep. 41(3): zsx209. doi:10.1093/sleep/zsx209

57) Fox BM, Becker BK, Loria AS, Hyndman KA, Jin CH, Clark H, Johns R, Yanagisawa M, Pollock DM,

Pollock JS (2018) Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived
Endothelin-1. J Am Heart Assoc. 7(4): e007863. doi:10.1161/JAHA.117.007863

58) Ikeda Y, Saitoh T, Niwa K, Nakajima T, Kitada N, Maki SA, Sato M, Citterio D, Nishiyama S, Suzuki K(2018) An allylated firefly luciferin analogue with luciferase specific response in living cells. Chem
Commun. 54(14):1774-1777. doi:10.1039/c7cc09720d

59) Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y,
Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2018) Essential structure of orexin 1
receptor antagonist YNT-707, Part II:Drastic effect of the 14-hydroxy group on the orexin 1 receptor
antagonistic activity. Bioorg Med Chem Lett. 28(4):774-777. doi:10.1016/j.bmcl.2017.12.069

60) Yuan XM, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T,
Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y(2018) Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity inadulthood. Nat Commun. 9:636. doi:10.1038/s41467-018-03038-w

61) Garcia SV, Brischoux F, Clement O, Libourel PA, Arthaud S, Lazarus M, Luppi PH, Fort P (2018)

Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep
behavior disorder. Nat Commun. 9:504. doi:10.1038/s41467-017-02761-0

62) Jung YS, Zhou, RY, Kato T, Usui, JK, Muratani, M, Oishi H, Heck MMS, Takahashi S (2018) Isl1 beta

Overexpression With Key beta Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin
Production and Secretion. Endocrinology. 159(2):869-882. doi:10.1210/en.2017-00663

63) Tateno K, Ogawa R, Sakamoto R, Tsuchiya M, Kutsumura N, Otani T, Ono K, Kawai H, Saito T (2018)
Dibenzopyrrolo[1,2-a][1,8]naphthyridines: Synthesis and Structural Modification of Fluorescent LShaped Heteroarenes. J Org Chem. 83(2):690-702. doi:10.1021/acs.joc.7b02674

University of Tsukuba -5
IIISAppendix 1-464) Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M (2018) The delta opioid
receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced
anxiety-like behaviors in mice. Behav Brain Res. 336:77-84. doi:10.1016/j.bbr.2017.08.041

65) Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M,

Nishino S, Shimizu T (2018) Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal
sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation.
Neuropsych Dis Treat. 14:1281-1286. doi:10.2147/NDT.S158865

66) Liguori G, Tafuri S, Miyoshi C, Yanagisawa M, Squillacioti C, De Pasquale V, Mirabella N, Vittoria A,
Costagliola A (2018) Localization of orexin B and orexin-2 receptor in the rat epididymis. ACTA
Histochem. 120(3):292-297. doi:10.1016/j.acthis.2018.02.011

67) Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K,

Uemura S, Shimizu T (2018) Orexin/hypocretin levels in the cerebrospinal fluid and characteristics ofpatients with myotonic dystrophy type 1 with excessive daytime sleepiness. Neuropsych Dis Treat.
14:451-457. doi:10.2147/NDT.S158651

68) Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M,

Yamagata K, Takahashi S (2018) Transcription factor MafB may play an important role in secondary
hyperparathyroidism. Kidney Int. 93(1):54-68. doi:10.1016/j.kint.2017.06.023

69) Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N,
Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2018) Novel non-alcoholic steatohepatitis model withhistopathological and insulin-resistant feature. Pathol Int. 68(1):12-22. doi:10.1111/pin.12612.

70) Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, Nagase H (2018)

Synthesis of Novel 1,3-Dioxa-5-thiazatriquinane and 1-Oxa-3,5-dithiazatriquinane Derivatives and their
Pharmacologies. Heterocycles. 97:687-695. doi: 10.3987/COM-18-S(T)40

2. Review articles
71) Doki,S, Sasahara S, Matsuzaki I (2018) Stress of working abroad: a systematic review. Int Arch Occup
Environ Health. 91(7):767-784. doi:10.1007/s00420-018-1333-4

72) Akers KG, Cherasse, Y, Fujita Y, Srinivasan S, Sakurai T, Sakaguchi M (2018) Concise Review: Regulatory
Influence of Sleep and Epigenetics on Adult Hippocampal Neurogenesis and Cognitive and Emotional
Function. Stem Cells. 36(7):969-976. doi:10.1002/stem.2815

73) Nakagawa Y, Shimano H (2018) CREBH Regulates Systemic Glucose and Lipid Metabolism. Int J Mol Sci.
19(5):1396. doi:10.3390/ijms19051396

3. Proceedings74) Lazarus M. (2018) The gating of sleep by motivated behavior. J Sleep Res. 27(1:SI):178.
75) Imanishi A, Ono T, Omori Y, Sagawa Y, Takahashi Y, Tsutsui K, Watanabe M, Kanbayashi T, Shimizu T(2018) INCREASING NUMBER OF CASES WHO HAD BOTH HYPERSOMNIA DISORDERS AND
DEVELOPMENTAL DISORDERS, SUCH AS ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) AND
AUTISM SPECTRUM DISORDER (ASD) IN JAPAN. Sleep. 41(1):A232-A233

76) Ito SU, Kanbayashi T, Suzuki S, Ito A, Kimoto Y, Terui Y, Satake M, Shioya T, Shimizu T, Nishino S (2018)
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Appendix 1-4

SLEEP FACILITATION BY AN ARTIFICIALLY CARBONATED SPRING; BODY TEMPERATURE, EEG AND
AUTONOMIC NERVOUS ACTIVITY EVALUATIONS. Sleep. 41(1):A144-A145.

4. Other English articles
77) Kashiwagi M, Hayashi Y (2018) Life Without Dreams: Muscarinic Receptors Are Required to Regulate
REM Sleep in Mice. Cell Rep. 24(9):2211-2212. doi:10.1016/j.celrep.2018.08.044

78) Fifel K, Videnovic A (2018) Light Therapy in Parkinson's Disease: Towards Mechanism-Based Protocols.
Trends Neurosci. 41(5):252-254. doi:10.1016/j.tins.2018.03.002

79) Fifel K (2018) Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment. J
Neurosci. 38(4):784-786. doi:10.1523/JNEUROSCI.3136-17.201780) Saitoh A, Nagase H (2018) Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development ofIndolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept. Handb Exp
Pharmacol. 247:3-19. doi:10.1007/164_2016_18

B. WPI-Related Papers
1. Original articles
81) Miyagawa T, Khor S, Toyod, H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y,

Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Takami M,
Higashiyama Y, Miyake R, Kondo H, Fujimura Y, Tamura Y, Taniyama Y, Omata N, Tanaka Y, Moriya S,
Furuya H, Kato M, Kawamura Y, Otowa T, Miyashita A, Kojima H, Saji H, Shimadal M, Yamasaki M,
Kobayashi T, Misawa R, Shigematsu Y, Kuwano R, Sasaki T, Ishigooka J, Wada Y, Tsuruta K, Chiba S,
Tanaka F, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y,
Mishima K, Honda M, Tokunaga K (2018) A variant at 9q34.11 is associated with HLA-DQB1*06:02
negative essential hypersomnia. J Hum Genet. 63(12):1259-1267.doi:10.1038/s10038-018-0518-8

82) Takeshima M, Ishikawa H, Kitadate A, Sasaki R, Kobayashi T, Nanjyo H, Kanbayashi T, Shimizu T (2018)

Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: a case report. BMC
Psychiatry. 18(1):150. doi:10.1186/s12888-018-1743-6.

83) Takeshima M, Shimizu T, Echizenya M, Ishikawa H, Kanbayashi T (2018) Inpatient phase-advancetherapy for delayed sleep-wake phase disorder: a retrospective study. Nat Sci Sleep. 10:327-333.
doi:10.2147/NSS.S179264

84) Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T (2018) Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells.
J Pathol. 244(1):84-96. doi:10.1002/path.4993

85) Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y (2018) A Hypothalamic Switch for REM
and Non-REM Sleep. Neuron. 97(5):1168-1176.e4. doi:10.1016/j.neuron.2018.02.005

86) Weber F, Hoang Do JP, Chung S, Beier KT, Bikov M, Saffari Doost M, Dan Y (2018) Regulation of REM
and Non-REM Sleep by Periaqueductal GABAergic Neurons. Nat Commun. 9(1):354. doi:10.1038/s41467017-02765-w

87) Mizukami H, Kim JD, Tabara S, Lu W, Kwon C, Nakashima M, Fukamizu A (2018) KDM5D-mediated H3K4

demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts. J
Biochem. 165(4):335-342. doi:10.1093/jb/mvy106
University of Tsukuba -7
IIISAppendix 1-4

88) Sato A, Kim JD, Mizukami H, Nakashima M, Kako K, Ishida J, Itakura A, Takeda S, Fukamizu A (2018)
Gestational changes in PRMT1
doi:10.1016/j.placenta.2018.04.001

expressionofmurineplacentas.

Placenta.

65:47-54.

89) Matsuzaki H, Okamura E, Kuramochi D, Ushiki A, Hirakawa K, Fukamizu A, Tanimoto K (2018) Synthetic
DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic
imprinting in transgenic mice. Epigenetics Chromatin. 11(1):36. doi:10.1186/s13072-018-0207-z

90) Yokoyama W, Hirota K, Wan H, Sumi N, Miyata M, Araoi S, Nomura N, Kako K, Fukamizu A (2018) rRNA
adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans. J Biochem.
163(6):465-474. doi:10.1093/jb/mvy018

91) Ohkuro M, Kim JD, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi-Kuramochi H, Muramoto K, Shirato M,

Michikawa-Tanaka F, Moriya J, Kozaki T, Takase K, Chiba K, Agarwala KL, Kimura T, Kotake M, Kawahara
T, Yoneda N, Hirota S, Azuma H, Ozasa-Komura N, Ohashi Y, Muratani M, Kimura K, Hishinuma I,
Fukamizu A (2018) Calreticulin and integrin alpha dissociation induces anti-inflammatory programmingin animal models of inflammatory bowel disease. Nat Commun. 9(1):1982. doi:10.1038/s41467-01804420-4

92) Araoi S, Daitoku H, Yokoyama A, Kako K, Hirota K, Fukamizu A (2018) The GATA transcription factor

ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans.
J Biochem. 163(5):433-440. doi:10.1093/jb/mvy012

93) Shigiyama F, Kumashiro N, Tsuneoka Y, Igarashi H, Yoshikawa F, Kakehi S, Funato H, Hirose T (2018)

Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice. Am J Physiol
Endocrinol Metab. 315(5):E848-E858. doi:10.1152/ajpendo.00072.201894) Green CB (2018) Circadian Posttranscriptional Regulatory Mechanisms in Mammals. Cold Spring Harb
Perspect Biol. 10(6) pii: a030692. doi:10.1101/cshperspect.a030692

95) Rosensweig C, Reynolds KA, Gao P, Laothamatas I, Shan Y, Ranganathan R, Takahashi JS, Green CB(2018) An evolutionary hotspot defines functional differences between CRYPTOCHROMES. Nat Commun.
9(1):1138. doi:10.1038/s41467-018-03503-6

96) Stubblefield JJ, Gao P, Kilaru G, Mukadam B, Terrien J, Green CB (2018) Temporal Control of Metabolic
Amplitude by Nocturnin. Cell Rep. 22(5):1225-1235. doi:10.1016/j.celrep.2018.01.011

97) Onder Y, Green CB (2018) Rhythms of metabolism in adipose tissue and mitochondria. Neurobiol Sleep
Circadian Rhythms. 4:57-63. doi:10.1016/j.nbscr.2018.01.001

98) Tsukada E, Kitamura S, Enomoto M, Moriwaki A, Kamio Y, Asada T, Arai T, Mishima K (2018) Prevalenceof childhood obstructive sleep apnea syndrome and its role in daytime sleepiness. PLoS One.
13(10):e0204409. doi:10.1371/journal.pone.0204409

99) Ayabe N, Okajima I, Nakajima S, Inoue Y, Watanabe N, Yamadera W, Uchimura N, Tachimori H, Kamei
Y, Mishima K (2018) Effectiveness of cognitive behavioral therapy for pharmacotherapy-resistant chronic
insomnia: a multi-center randomized controlled trial in Japan. Sleep Med. 50:105-112
doi:10.1016/j.sleep.2018.05.038

100) Kishi T, Ikuta T, Matsui Y, Inada K, Matsuda Y, Mishima K, Iwata N (2018) Effect of discontinuation

v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episodepsychosis: a meta-analysis. Psychol Med. 18:1-8. doi:10.1017/S0033291718001393

101) Okada M, Otaga M, Tsutsui T, Tachimori H, Kitamura S, Higuchi S, Mishima K (2018) Association of

sleep with emotional and behavioral problems among abused children and adolescents admitted toresidential care facilities in Japan. PLoS One. 13(6):e0198123. doi:10.1371/journal.pone.0198123
University of Tsukuba -8
IIISAppendix 1-4102) Shima Y, Miyabayashi K, Sato T, Suyama M, Ohkawa Y, Doi M, Okamura H, Suzuki K (2018) Fetal

Leydig cells dedifferentiate and serve as adult Leydig stem cells. Development. 145(23) pii: dev169136.
doi:10.1242/dev.169136

103) Yamaguchi Y, Okamura H (2018) Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under
Chronic Jet Lag. iScience. 5:118-122. doi:10.1016/j.isci.2018.06.008

104) Fustin JM, Kojima R, Itoh K, Chang HY, Ye S, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D,

Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, Okamura H (2018) Two Ck1δ transcripts regulated
by m6A methylation code for two antagonistic kinases in the control of the circadian clock. Proc Natl
Acad Sci USA. 115(23):5980-5985. doi:10.1073/pnas.1721371115

105) Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM(2018) CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. Proc Natl Acad Sci USA.
115(23):5986-5991. doi:10.1073/pnas.1721076115

106) Sengiku A, Ueda M, Kono J, Sano T, Nishikawa N, Kunisue S, Tsujihana K, Liou LS, Kanematsu A,
Shimba S, Doi M, Okamura H, Ogawa O, Negoro H (2018) Circadian coordination of ATP release in theurothelium via connexin43 hemichannels. Sci Rep. 8(1):1996. doi:10.1038/s41598-018-20379-0

107) Goda T, Doi M, Umezaki Y, Murai I, Shimatani H, Chu ML, Nguyen VH, Okamura H, Hamada FN (2018)
Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and bodytemperature in mammals. Genes Dev. 32(2):140-155. doi:10.1101/gad.307884.117

108) Chen Y, Yamaguchi Y, Suzuki T, Doi M, Okamura H (2018) Effect of Daily Light on c-Fos Expression

in the Suprachiasmatic Nucleus under Jet Lag Conditions. Acta Histochem Cytochem. 51(2):73-80.
doi:10.1267/ahc.18001

109) Ito K, Yasuda M, Maeda Y, Fustin JM, Yamaguchi Y, Kono Y, Negoro H, Kanematsu A, Ogawa O, Doi

M, Okamura H (2018) Circadian rhythms of micturition during jet lag. Biomed Res. 39(2):57-63.
doi:10.2220/biomedres.39.57

110) Tainaka M, Doi M, Inoue Y, Murai I, Okamura H (2018) Circadian PER2 protein oscillations do not

persist in cycloheximide-treated mouse embryonic fibroblasts in culture. Chronobiol Int. 35(1):132-136.
doi:10.1080/07420528.2017.1316731

111) Yeoh JW, James MH, Adams CD, Bains JS, Sakurai T, Aston-Jones G, Graham BA, Dayas CV (2018)

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaineseeking following abstinence and normalizes drug-associated increases in excitatory drive toorexin/hypocretin cells. Neuropharmacology. pii:S0028-3908(18)30696-8.
doi:10.1016/j.neuropharm.2018.09.033

112) Sladek V, Tokiwa H, Shimano H, Shigeta Y (2018) Protein Residue Networks from Energetic andGeometric Data: Are They
doi:10.1021/acs.jctc.8b00733

Identical?

J

Chem

TheoryComput.

11;14(12):6623-6631.

113) Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano

H, Kato K, Tanaka S, Sone H (2018) Relationship between intake of fruit separately from vegetables andtriglycerides - A meta-analysis. Clin Nutr ESPEN. 27:53-58. doi:10.1016/j.clnesp.2018.07.001

114) Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y (2018) Brg1 regulates pro-lipogenictranscription by modulating SREBP activity in hepatocytes. Biochim Biophys Acta Mol Basis Dis. 1864(9Pt B):2881-2889. doi:10.1016/j.bbadis.2018.05.022

115) Nakagawa Y, Shimano H (2018) CREBH Regulates Systemic Glucose and Lipid Metabolism. Int J Mol
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IIISAppendix 1-4

Sci. 19(5) pii: E1396. doi:10.3390/ijms19051396

116) Corty RW, Kumar V, Tarantino LM, Takahashi JS, Valdar W (2018) Mean-Variance QTL Mapping
Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice. G3 (Bethesda). 8(12):37833790. doi:10.1534/g3.118.200194

117) Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P,

Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES (2018) CellAutonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. Cell Rep. 25(1):19.e5. doi:10.1016/j.celrep.2018.09.015

118) Ye Y, Xiang Y, Ozguc FM, Kim Y, Liu CJ, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo AY, Zhou B, Wang
L, Chen Z, Takahashi JS, Mills GB, Yoo SH, Han L (2018) The Genomic Landscape and Pharmacogenomic
Interactions of Clock Genes in Cancer Chronotherapy. Cell Syst. 6(3):314-328.e2.
doi:10.1016/j.cels.2018.01.013

119) Rijo-Ferreira F , Carvalho T, Afonso C, Sanches-Vaz M, Costa RM, Figueiredo LM, Takahashi JS (2018)
Sleeping sickness is a circadian disorder. Nat Commun. 9(1):62. doi:10.1038/s41467-017-02484-2

120) Hori Y, Tanimoto Y, Takahashi S, Furukawa T, Koshiba-Takeuchi K, Takeuchi JK (2018) Important

cardiac transcription factor genes are accompanied by bidirectional long non-coding RNAs. BMC
Genomics. 19(1):967. doi:10.1186/s12864-018-5233-5

121) Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F,

Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y,
Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi
I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa
S, Ito E (2018) De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure
Syndrome. Am J Hum Genet. 103(3):440-447. doi:10.1016/j.ajhg.2018.07.020

122) Mao XW, Byrum S, Nishiyama NC, Pecaut MJ, Sridharan V, Boerma M, Tackett AJ, Shiba D, Shirakawa

M, Takahashi S, Delp MD (2018) Impact of Spaceflight and Artificial Gravity on the Mouse Retina:
Biochemical and Proteomic Analysis. Int J Mol Sci. 19(9) pii: E2546. doi:10.3390/ijms19092546

123) Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa

Y, Hase K, Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, Tanaka M, Asano K (2018)
Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases ofInflammation. J Immunol. 201(2):635-651. doi:10.4049/jimmunol.1800040

124) Horie K, Kudo T, Yoshinaga R, Akiyama N, Sasanuma H, Kobayashi TJ, Shimbo M, Jeon H, Miyao T,

Miyauchi M, Shirakawa M, Shiba D, Yoshida N, Muratani M, Takahashi S, Akiyama T (2018) Long-term
hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing
autoimmune
regulator(Aire).
Biochem
BiophysRes
Commun.
501(3):745-750.
doi:10.1016/j.bbrc.2018.05.060

125) Kubota T, Inoue M, Kubota N, Takamoto I, Mineyama T, Iwayama K, Tokuyama K, Moroi M, Ueki K,
Yamauchi T, Kadowaki T (2018) Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 9(1):4863. doi:10.1038/s41467018-07358-9

126) Egerod KL, Petersen N, Timshel PN, Rekling JC, Wang Y, Liu QH, Schwartz TW, Gautron L (2018)

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.
Mol Metab. 12:62-75. doi: 10.1016/j.molmet.2018.03.016.

127) Kubota T, Inoue M, Kubota N, Takamoto I, Mineyama T, Iwayama K, Tokuyama K, Moroi M, Ueki K,
Yamauchi T, Kadowaki T (2018) Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4University of Tsukuba -10
IIISAppendix 1-4

indeuced M2a-subtype macrophage activation in obesity. Nature Commun. 9:4863. doi:10.1038/s41467018-07358-9

2. Review articles
128) Takeshima M, Ishikawa H, Shimizu K, Kanbayashi T, Shimizu T (2018) Incidence of venous

thromboembolism in psychiatric inpatients: a chart review. Neuropsychiatr Dis Treat. 14:1363-1370.
doi:10.2147/NDT.S162760

129) Doki S, Sasahara S, Matsuzaki I (2018) Stress of working abroad: a systematic review. Int Arch Occup
Environ Health. 91(7):767-784. doi:10.1007/s00420-018-1333-4

130) Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K,

Hanyu O, Sone H (2018) Quantitative Relationship Between Cumulative Risk Alleles Based on GenomeWide Association Studies and Type 2 Diabetes Mellitus. J Epidemiol. 28(1): 3-18.
doi:10.2188/jea.JE20160151

131) Takeshima M, Ishikawa H, Kanbayashi T, Shimizu T (2018) Gabapentin enacarbil for antipsychotic

induced akathisia in schizophrenia patients: a pilot open-labeled study. Neuropsychiatr Dis Treat.
14:3179-3184. doi:10.2147/NDT.S184081

3. Proceedings132) Sato A, Kim JD, Mizukami H, Nakashima M, Kako K, Ishida J, Itakura A, Takeda S, Fukamizu A (2018)
Gestational changes in PRMT1
doi:10.1016/j.placenta.2018.04.001

expressionofmurineplacentas.

Placenta.

65:47-54

133) Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura
A, Takeshima H (2018) Gm7325 Transcription Is Regulated by MyoD in Activated Muscle Satellite Cells.
Biophys. J. 114(3):628a. doi: 10.1016/j.bpj.2017.11.3394

134) Tateishi R, Matsumura T, Uchino K, Fujiwara N, Senokuchi T, Kon K, Sasako T, Taniai M, Kawaguchi

T, Inoue H, Watada H, Kubota N, Shimano H, Kaneko S, Hashimoto E, Watanabe S, Shiota G, Ueki K,
Kashiwabara K, Matsuyama Y, Tanaka H, Kasuga M, Araki E, Koike K (2018) Hepatocellular Carcinoma
Development in Patients with Diabetes Mellitus: A Nationwide Case-Control Study. Hepatology 68:528A.

135) Usui T, Morito N, Hamada M, Yoh K, Usui J, Takahashi S, Yamagata K (2018) TRANSCRIPTION

FACTOR MAFB GENETIC OVEREXPRESSION IN PODOCYTES, OR THE MAFB INDUCER PROTECTS
AGAINST FOCAL SEGMENTAL GLOMERULAR SCLEROSIS IN MICE. Nephrol Dial Transplant. 33

136) Chen Z, Yoo SH, Takahashi JS (2018) Development and Therapeutic Potential of Small-Molecule
Modulators of Circadian Systems. Annu Rev Pharmacol Toxicol. 58:231-252. doi:10.1146/annurevpharmtox-010617-052645

4. Other English articles
137) Ono T, Kanbayashi T, Yonezawa K, Nishio S, Shimizu T (2018)Measurement of cerebrospinal fluid
orexin-A (hypocretin-1) by enzyme-linked immunosorbent assay: A comparison with radioimmunoassay.
Psychiatry Clin Neurosci. 72(11):849-850. doi: 10.1111/pcn.12780

138) Takeshima Masahiro, Ishikawa Hiroyasu, Kikuchi Yuka, Kanbayashi Takashi, Shimizu Tetsuo (2018)
Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report. Clin
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Psychopharmacol Neurosci. 16(3):346-348. doi: 10.9758/cpn.2018.16.3.346

139) Takeshima M, Ishikawa H, Ono T, Kanbayashi T, Shimizu T (2018) A case of perampanel-induced

delirium in a patient with symptomatic epilepsy. Seizure. 58:154-155. doi:10.1016/j.seizure.2018.04.014

140) Kanou A, Kako K, Hirota K, Fukamizu A (2018) PRMT-5 converts monomethylarginines into
symmetricaldimethylargininesdoi:10.1093/jb/mvy024

inCaenorhabditis

elegans.

J

Biochem.

163(4):351.

141) Greene RW (2018) Defining the Role of Interneuron N-Methyl-D-Aspartate Receptors in Prefrontal
Cortex Inhibition. Biol Psychiatry. 84(6):399-400. doi:10.1016/j.biopsych.2018.06.022

142) Benedetti F, Avery DH, Bauer M, Bunney WE, Çaliyurt O, Camardese G, Colombo C, Dallaspezia S,

Henriksen TE, Kasper S, Kuriyama K, Lam RW, Martiny K, Meesters Y, Mishima K, Schulte R, Suzuki M,Święcicki Ł, Uchiyama M, Veale D, Winkler D, Wu J, Kupeli NY, Yoshiike T, Yu X (2018) Evidence for the
Efficacy of Bright Light Therapy for Bipolar Depression. Am J Psychiatry. 175(9):905-906.
doi:10.1176/appi.ajp.2018.18020231

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