FY2016

List of Publications FY 2016
A. WPI papers
1.) Original articles
01. Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang ZQ, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki
M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T,
Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S,
Sakimura K, Hayashi Y, Liu QH, Kume K, Wakana S, Takahashi JS, Yanagisawa M (2016) Forward-genetics
analysis of sleep in randomly mutagenized mice. Nature 539(7629): 378-383. doi:10.1038/nature20142
02. Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T,
Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H,
Yanagisawa M (2016) Identification of mutations through dominant screening for obesity using C57BL/6
substrains. Sci Rep 6: 34253. doi:10.1038/srep32453
03. Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H (2016) High-fat diet feeding alters olfactory-, social-,
and reward-related behaviors of mice independent of obesity. Obesity 24(4): 886-894.
doi:10.1002/oby.21441
04. Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M, Smith CC, FernandezG, Deisseroth K, Greene RW, Morris RGM (2016) Locus coeruleus and dopaminergic consolidation of everyday
memory. Nature 537(7620): 357-362. doi:10.1038/nature19325
05. Bjorness TE, Dale N, Mettlach G, Sonneborn A, Sahin B, Fienberg AA, Yanagisawa M, Bibb JA, Greene RW(2016) An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep. J. Neurosci. 36(13): 3709-3721.
doi:10.1523/JNEUROSCI.3906-15.2016
06. McEown K, Takata Y, Cherasse Y, Nagata N, Aritake K, Lazarus M (2016) Chemogenetic inhibition of themedial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. eLife 5: e20269.
doi:10.7554/eLife.20269
07. Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe
D, Furuyashiki T, Narumiya S (2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling
Regulating Synaptic Efficacy and Anxiety. Cell Reports 17(9): 2405-2417. doi:10.1016/j.celrep.2016.10.088
08. Kong DP, Shen YJ, Liu GZ, Zuo SK, Ji Y, Lu AK, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y
(2016) PKA regulatory II alpha subunit is essential for PGD(2)-mediated resolution of inflammation. J. Exp.
Med. 213(10): 2209-2226. doi:10.1084/jem.20160459
09. Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM,
Huang ZL (2016) Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition ofElectroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice.
Neuropsychopharmacology 41(8): 2133-2146. doi:10.1038/npp.2016.13
10. Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Lofberg A, Jaarola M,
Kugelberg UO, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schuetz G, Parkitna
JR, Saper CB, Blomqvist A, Engblom D (2016) Prostaglandin-dependent modulation of dopaminergic
neurotransmission elicits inflammation- induced aversion in mice. J. Clin. Invest. 126(2): 695-705.
doi:10.1172/JCI83844
11. Fujinaka A, Li RS, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai
T, Kee N, Nakajima S, Wang SH, Sakaguchi M (2016) Effect of context exposure after fear learning on
memory generalization in mice. Mol. Brain 9:2 doi:10.1186/s13041-015-0184-0

1

FY2016

12. Oishi Y, Takata Y, Taguchi Y, Kohtoh S, Urade Y, Lazarus M (2016) Polygraphic Recording Procedure for
Measuring Sleep in Mice. J. Vis. Exp 107: e53678. doi:10.3791/53678
13. Doki S, Kaneko H, Oi Y, Usami K, Sasahara S, Matsuzaki I (2016) Risk Factors for Suicidal Ideation Among
Telephone Crisis Hotline Callers in Japan. Crisis 37(6): 438-444. doi:10.1027/0227-5910/a000384
14. Doki S, Sasahara S, Oi Y, Matsuzaki I (2016) A survey of support systems for return to work in Japanesecompanies: a cross-sectional study. Ind. Health 54(6): 564-572. doi:10.2486/indhealth.2015-0185
15. Doki S, Sasahara S, Hirai Y, Oi Y, Matsuzaki I (2016) Absenteeism due to mental health problems andsystems for return to work: an internet-based unmatched case-control study. Int. Arch. Occup. Environ.
Health 89(8): 1279-1287. doi:10.1007/s00420-016-1162-2
16. Yajima S, Saitoh T, Kawa K, Nakamura K, Nagase H, Einaga Y, Nishiyama S (2016) Asymmetric induction
in cyclohexadienones carrying alpha-D-glucopyranosyl moiety. Tetrahedron 72(51): 8428-8435.
doi:10.1016/j.tet.2016.10.068
17. Kutsumura N, Koyama Y, Tateno K, Yamamoto N, Nagase H, Saito T (2016) ZnCl2-Promoted
Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of
Dihydrodibenzo[b,g][1,8]naphthyridines. Chem. Pharm. Bull. 64(9): 1364-1369. doi:10.1248/cpb.c16-00363
18. Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H (2016)
Odour-induced analgesia mediated by hypothalamic orexin neurons in mice. Sci Rep 6: 37129.
doi:10.1038/srep37129
19. Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T,
Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T (2016) QRFP-Deficient Mice Are Hypophagic, Lean,
Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One 11(11): e0164716.
doi:10.1371/journal.pone.0164716
20. Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa
M, Sakurai T, Sasaoka, T (2016) Timed Inhibition of Orexin System by Suvorexant Improved Sleep and
Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology 157(11): 4146-4157. doi:10.1210/en.20161404
21. Mieda M, Okamoto H, Sakurai T (2016) Manipulating the Cellular Circadian Period of Arginine Vasopressin
Neurons Alters the Behavioral Circadian Period. Curr. Biol. 26(18): 2535-2542. doi:10.1016/j.cub.2016.07.022
22. Tsuneki H, Sasaoka T, Sakurai T. Sleep Control, GPCRs, and Glucose Metabolism (2016) Trends
Endocrinol. Metab. 27(9): 633-642. doi:10.1016/j.tem.2016.06.011
23. Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M(2016) Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc. Natl. Acad.
Sci. U.S.A. 113(21): 6023-6028. doi:10.1073/pnas.1518658113
24. Tsuneki H, Nagata T, Fujita M, Kon K, Wu NZ, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa
M, Sakurai T, Sasaoka T (2016) Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism
via the Hypothalamic Orexin System in Mice. Endocrinology 157(1): 195-206. doi:10.1210/en.2015-1488
25. Nakagawa Y, Satoh A, Tezuka H, Han S, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone
H, Matsuzaka T, Yamada N, Shimano H (2016) CREB3L3 controls fatty acid oxidation and ketogenesis insynergy with PPAR alpha. Sci Rep 6: 39182. doi:10.1038/srep39182
26. Sunaga H, Matsui H, Anjo S, Syamsunarno MRAA, Koitabashi N, Iso T, Matsuzaka T, Shimano H,
Yokoyama T, Kurabayashi M (2016) Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven
Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein

2

FY2016

Kinase/Kruppel-Like Factor 4 (AMPK/KLF4) Signaling. J. Am. Heart Assoc. 5(12): e004014. doi:
10.1161/JAHA.116.004014
27. Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y,
Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H(2016) Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia byreducing Npc1l1 expression. Mol. Metab. 5(11): 1092-1102. doi:10.1016/j.molmet.2016.09.004
28. Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H (2016)
Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.
PLoS One 11(7): e0159375. doi:10.1371/journal.pone.0159375
29. Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han S, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki
H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H (2016)
Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced NonAlcoholic Fatty Liver Disease in Mice. PLoS One 11(6): e0157580. doi:10.1371/journal.pone.0157580
30. Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han S,
Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N,
Shimano H (2016) Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a
one-step CRISPR/Cas9 system. Sci Rep 6: 27857. doi:10.1038/srep27857
31. Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T(2016) Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with orwithout midbrain involvement A case series. Medicine(Baltimore) 95(29): e4281.
doi:10.1097/MD.0000000000004281
32. Omokawa M, Ayabe T, Nagai T, Imanishi A, Omokawa A, Nishino S, Sagawa Y, Shimizu T, Kanbayashi T(2016) Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome. Am. J. Med. Genet. A 170(5):1181-1186. doi:10.1002/ajmg.a.37542
33. Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida
S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M (2016) Peripherally
administered orexin improves survival of mice with endotoxin shock. eLife 5: e21055. doi:10.7554/eLife.21055
34. Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M (2016)
Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice andEpiblast Stem Cells. PLoS One 11(7): e0159246. doi:10.1371/journal.pone.0159246
35. Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S,
Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F (2016) Generation of CRISPR/Cas9-mediated bicistronic
knock-in ins1-cre driver mice. Exp. Anim. 65 (3): 319-327. doi:10.1538/expainm.16-0016
36. Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, ElShemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F (2016) Germline
recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54(7): 389-397.
doi:10.1002/dvg.22944
37. Tran MTN, Hamada M, Nakamura M, Jeon H, Kamei R, Tsunakawa Y, Kulathunga K, Lin YY, Fujisawa K,
Kudo T, Takahashi S (2016) MafB deficiency accelerates the development of obesity in mice. FEBS Open Bio
6(6): 540-547. doi:10.1002/2211-5463.12058
38. Daassi D, Hamada M, Jeon H, Imamura Y, Tran MTN, Takahashi S (2016) Differential expression patternsof MafB and c-Maf in macrophages in vivo and in vitro. Biochem. Biophys. Res. Commun. 473(1): 118-124.
doi:10.1016/j.bbrc.2016.03.063

3FY2016

39. Jeon H, Waku T, Azami T, Khoa LTP, Yanagisawa J, Takahashi S, Ema M (2016) Comprehensive
Identification of Kruppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic
Stem Cells and Cellular Reprogramming. PLoS One 11(3): e0150715. doi:10.1371/journal.pone.0150715
40. Abdellatif' AM, Oishi H, Itagaki T, Jung YS, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, ElSayed MA, Shoaib MB, Sugiyama F, Takahashi S (2016) beta-Cell-Specific Mafk Overexpression Impairs
Pancreatic Endocrine Cell Development. PLoS One 11(2): e0150010. doi:10.1371/journal.pone.0150010
41. Matsuyama M, Ishii Y, Sakurai H, Ano S, Morishima Y, Yoh K, Takahashi S, Ogawa K, Hizawa N (2016)
Overexpression of ROR gamma t Enhances Pulmonary Inflammation after Infection with Mycobacterium
Avium. PLoS One 11(1): e0147064. doi:10.1371/journal.pone.0147064
42. Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, Murata T (2016) Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One 11(12): e0167729.
doi:10.1371/journal.pone.0167729
43.Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama
A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast(Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A(2A)
receptors. J. Sleep Res. 25(6): 746-753. doi:10.1111/jsr.12434
44. Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T,
Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y (2016) Japanese sake yeast supplementation
improves the quality of sleep: a double-blind randomised controlled clinical trial. J. Sleep Res. 25(1): 116-123.
doi:10.1111/jsr.12336
45. Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA(2016) The calcium sensor
Copine-6 regulates spine structural plasticity and learning and memory. Nat. Commun. 7: 11613.
doi:10.1038/ncomms11613
46. Hyndman KA, Dugas C, Arguello AM, Goodchild TT, Buckley KM, Burch M, Yanagisawa M, Pollock JS(2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via
upregulated ETB receptor expression. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 311(2): R263-R271.
doi:10.1152/ajpregu.00016.2015
47. Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O,
Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H,
Yanagita M (2016) Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.
JCI Insight 1(11): e87860. doi:10.1172/jci.insight.87680
48. Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A (2016)
Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis
Res. Ther. 18(1): 113. doi:10.1186/s13075-016-1011-4
49. Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM (2016) Functional ETA-ETB Receptor
Cross-talk in Basilar Artery In Situ From ETB Receptor Deficient Rats. J. Cardiovasc. Pharmacol. 67(3): 212217. doi:10.1097/FJC.0000000000000335
50. Kutsumura N, Numata K, Saito T (2016) First total synthesis of haplacutine C. Tetrahedron Lett. 57(50):5581-5583. doi:10.1016/j.tetlet.2016.10.070
51. Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG (2016) A TPX2 Proteomimetic Has Enhanced
Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. ACS Chem. Biol. 11(12): 3383-3390.
doi:10.1021/acschembio.6b00727

4

FY2016

52. Ioka S, Saitoh T, Maki SA, Imoto M, Nishiyama S (2016) Development of a luminescence-controllable
firefly luciferin analogue using selective enzymatic cyclization. Tetrahedron 72(47): 7505-7508.
doi:10.1016/j.tet.2016.09.069
53. Honda T, Lee CY, Honjo K, Furukubo-Tokunaga K (2016) Artificial Induction of Associative Olfactory
Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic
Neurons in Drosophila Larvae. Front. Behav. Neurosci. 10: 137. doi:10.3339/fnbeh.2016.00137
54. Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S (2016) Synthesis ofFirefly Luciferin Analogues and Evaluation of the Luminescent Properties. Chem.-Eur. J. 22(27): 9330-9337.
doi:10.1002/chem.201600278
55. Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J(2016) OPIOID SYSTEMS IN THE LATERAL HYPOTHALAMUS REGULATE FEEDING BEHAVIOR THROUGH
OREXIN AND GABA NEURONS. Neuroscience 320(183): 193 doi: 10.1016/j.neuroscience.2016.02.002

2.) Review articles
56. Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H (2016) Sleep as a biologicalproblem: an overview of frontiers in sleep research. J. Physiol. Sci 66(1): 1-13.
doi:10.1007/s12576-015-0414-3
57. Saito T, Kobayashi S, Otani T, Kutsumura N (2016) Development of Synthetic Methodologies for
Heterocycles Using Diene-transmissive Hetero-Diels-Alder Reaction. J. Synth. Org. Chem. Jpn. 74(8): 803813. doi:10.5059/yukigoseikyokaishi.74.803

3.) Proceedings
58. Ikeda H, Ardianto C, Yonemochi N, Yamamoto S, Yang LZ, Takenoya F, Shioda S, Nagase H, Kamei J(2016) Hypothalamic opioid receptors control feeding behavior though orexin and GABA Neurons. Int. J.
Neuropsychopharmacol. 19(Suppl_1): 57. doi:10.1093/ijnp/pyw044.706
59. Sakurai T (2016) Neural Circuits of Orexin Neurons: Interface of Systems of Emotion, Energy Homeostasis
and Arousal. Int. J. Neuropsychopharmacol. 19: 325
60. Lazarus M, Oishi Y (2016) Why do we fall asleep when bored? - The role of the nucleus accumbens insleep-wake regulation. J. Sleep Res. 25(1:SI): 94-94.

B. WPI-related papers
1.) Original articles
61. Zhang SY, Xu M, Chang WC, Ma CY, Do JPH, Jeong D, Lei T, Fan JL, Dan Y (2016) Organization of longrange inputs and outputs of frontal cortex for top-down control. Nat. Neurosci. 19(12): 1733-1742
doi:10.1038/nn.4417
62. Do JP, Xu M, Lee SH, Chang WC, Zhang SY, Chung S, Yung TJ, Fan JL, Miyamichin K, Luo LQ, Dan Y(2016) Cell type-specific long-range connections of basal forebrain circuit. eLife 5: e13214.
doi:10.7554/eLife.13214
63. Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW,
Fishell G, Mullins C, Goncalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsaki G, Stevens C(2016) What is memory? The present state of the engram. BMC Biol. 14:40. doi:10.1186/s12915-016-0261-6

5FY2016

64. Harrison TC, Pinto L, Brock JR, Dan Y (2016) Calcium Imaging of Basal Forebrain Activity during Innateand Learned Behaviors. Front. Neural Circuits 10:36. doi:10.3389/fncir.2016.00036
65. Liu L, She L, Chen M, Liu TY, Lu HDD, Dan Y, Poo MM (2016) Spatial structure of neuronal receptive field
in awake monkey secondary visual cortex (V2). Proc. Natl. Acad. Sci. U.S.A. 113(7): 1913-1918.
doi:10.1073/pnas.1525505113
66. Cox J, Pinto L, Dan Y (2016) Calcium imaging of sleep-wake related neuronal activity in the dorsal pons.
Nat. Commun. 7: 10763. doi:10.1038/ncomms10763
67. Ushiki A, Matsuzaki H, Ishida J, Fukamizu A, Tanimoto K (2016) Long-Range Control of Renin Gene
Expression in Tsukuba Hypertensive Mice. PLoS One 11(11): e0166974. doi:10.1371/journal.pone.0166974
68. Daitoku H, Kaneko Y, Yoshimochi K, Matsumoto K, Araoi S, Sakamaki J, Takahashi Y, Fukamizu A (2016)
Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. Mol. Cell. Biol.
36(21): 2755-2766. doi:10.1128/MCB.00265-16
69. Sasaki T, Tanaka Y, Kulkeaw K, Yumine-Takai A, Tan KS, Nishinakamura R, Ishida J, Fukamizu A,
Sugiyama D (2016) Embryonic Intra-Aortic Clusters Undergo Myeloid Differentiation Mediated by
Mesonephros-Derived CSF1 in Mouse. Stem Cell Rev. Rep. 12(5): 530-542. doi:10.1007/s12015-016-9668-2
70. Egashira Y, Takase M, Watanabe S, Ishida J, Fukamizu A, Kaneko R, Yanagawa Y, Takamori S (2016)
Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading.
Proc. Natl. Acad. Sci. U.S.A. 113(38): 10702-10707. doi:10.1073/pnas.1604527113
71. Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, UranoY. (2016) Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution. Angew. Chem.-Int. Edit.
55(33): 9619-9623. doi:10.1002/anie.201603328
72. Kaneko Y, Daitoku H, Komeno C, Fukamizu A (2016) CTF18 interacts with replication protein A in
response to replication stress. Mol. Med. Rep. 14(1): 367-372. doi:10.3892/mmr.2016.5262
73. Waku T, Nakajima Y, Yokoyama W, Nomura N, Kako K, Kobayashi A, Shimizu T, Fukamizu A (2016) NMLmediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent
manner. J. Cell Sci. 129(12): 2382-2393. doi:10.1242/jcs.183723
74. Murata K, Ishida J, Ishimaru T, Mizukami H, Hamada J, Saito C, Fukamizu A (2016) Lactation Is a Risk
Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression.
J. Biol. Chem. 291(21): 11241-11251. doi:10.1074/jbc.M115.699009
75. Itoh Y, Fuchino H, Sanosaka M, Kako K, Hada K, Fukamizu A, Takemori H, Kawahara N (2016) Pterosin B
has multiple targets in gluconeogenic programs, including coenzyme Q in ROR alpha-SRC2 signaling.
Biochem. Biophys. Res. Commun. 473(2): 415-420. doi:10.1016/j.bbrc.2016.03.016
76. Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami
K, Ishikawa C, Li HY, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane
M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R,
Wang YY, Ito T, Kokubu Y, Noguchi TAK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N,
Takeda S, Takahashi S (2016) Ground-based assessment of JAXA mouse habitat cage unit by mouse
phenotypic studies. Exp. Anim. 65(2): 175-187. doi:10.1538/expanim.15-0077
77. Toma-Fukai S, Kim JD, Parka KE, Kuwabara N, Shimizu N, Krayukhina E, Uchiyama S, Fukamizu A,
Shimizu T (2016) Novel helical assembly in arginine methyltransferase 8. J. Mol. Biol. 428(6): 1197-1208
doi:10.1016/j.jmb.2016.02.007
78. Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, Fukamizu A (2016) Severe Hypomyelination andDevelopmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the

6

FY2016

Central Nervous System. J. Biol. Chem. 291(5): 2237-2245. doi:10.1074/jbc.M115.684514
79. Lopez-Huerta VG, Nakano Y, Bausenwein J, Jaidar O, Lazarus M, Cherassse Y, Garcia-Munoz M,
Arbuthnott G (2016) The neostriatum: two entities, one structure? Brain Struct. Funct. 221(3): 1737-1749.
doi:10.1007/s00429-015-1000-4
80. Lopez-Huerta VG, Nakano Y, Bausenwein J, Jaidar O, Lazarus M, Cherassse Y, Garcia-Munoz M,
Arbuthnott G (2016) The neostriatum: two entities, one structure? (vol 221, pg 1737, 2016) Brain Struct.
Funct. 221(3): 1789-1789. doi:10.1007/s00429-015-1017-8
81. Liu HM, Liang CY, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang ZQ, Yoo KS, Yadav GP, Kinch LN, Grishin
NV, Nam Y, Corey DR, Kittler R, Liu QH (2016) HP1BP3, a Chromatin Retention Factor for Co-transcriptional
MicroRNA Processing. Mol. Cell 63(3): 420-432. doi:10.1016/j.molcel.2016.06.014
82. Hori D, Tsujiguchi H, Kambayashi Y, Hamagishi T, Kitaoka M, Mitoma J, Asakura H, Suzuki F, Anyenda EO,
Nguyen TTT, Hibino Y, Shibata A, Hayashi K, Sagara T, Sasahara S, Matsuzaki I, Hatta K, Konoshita T,
Nakamura H (2016) The associations between lifestyles and mental health using the General Health
Questionnaire 12-items are different dependently on age and sex: a population-based cross-sectional study in
Kanazawa, Japan. Environ. Health Prev. 21(6): 410-421. doi:10.1007/s12199-016-0541-3
83. Komatsu T, Katsuyama S, Nagase H, Mizoguchi H, Sakurada C, Tsuzuki M, Sakurada S, Sakurada T (2016)
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal
cord. Pharmacol. Biochem. Behav. 140: 68-74. doi:10.1016/j.pbb.2015.10.010
84. Okamura H, Doi M, Goto K, Kojima R (2016) Clock genes and salt-sensitive hypertension: a new type ofaldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II. Hypertens. Res. 39(10):681-687. doi:10.1038/hr.2016.91
85. Kobayakawa M, Okamura H, Yamagishi A, Morita T, Kawagoe S, Shimizu M, Ozawa T, An E, Tsuneto S,
Shima Y, Miyashita M (2016) Family caregivers require mental health specialists for end-of-life psychosocial
problems at home: a nationwide survey in Japan. Psycho-Oncol. 25(6): 641-647. doi:10.1002/pon.3982
86. Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW,Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H (2016)
Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behavior. Nat.
Commun. 7: 10583. doi:10.1038/ncomms10583
87. Yamaguchi Y, Okada K, Mizuno T, Ota T, Yamada H, Doi M, Kobayashi M, Tei H, Shigeyoshi Y, Okamura H(2016) Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely
Moving Rats. J. Biol. Rhythms 31(1): 108-111. doi:10.1177/0748730415621412
88. Seo D, Kitashima M, Sakurai T, Inoue K (2016) Kinetics of NADP(+)/NADPH reduction-oxidation catalyzed
by the ferredoxin-NAD(P)(+) reductase from the green sulfur bacterium Chlorobaculum tepidum. Photosynth.
Res. 130(42738): 479-489. doi:10.1007/s11120-016-0285-3
89. Akter M, Inoue C, Komori H, Matsuda N, Sakurai T, Kataoka K, Higuchi Y, Shibata N (2016) Biochemical,
spectroscopic and X-ray structural analysis of deuterated multicopper oxidase CueO prepared from a new
expression construct for neutron crystallography. Acta Crystallogr. F-Struct. Biol. Commun. 72: 788-794.
doi:10.1107/S2053230X1601400X
90. Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko
S, Wada T (2016) Messenger RNA expression profile of sleep-related genes in peripheral blood cells inpatients with chronic kidney disease. Clin. Exp. Nephrol. 20(2): 218-225. doi:10.1007/s10157-015-1150-y
91. Yoshizawa S, Kodama S, Fujihara K, Ishiguro H, Ishizawa M, Matsubayashi Y, Matsunaga S, Yamada T,
Shimano H, Kato K, Hanyu O, Sone H (2016) Utility of nonblood-based risk assessment for predicting type 2
diabetes mellitus: A meta-analysis. Prev. Med. 91: 180-187. doi:10.1016/j.ypmed.2016.07.026

7FY2016

92. Ibe Y, Miyakawa H, Fuse-Nagase Y, Hirose AS, Hirasawa R, Yachi Y, Fujihara K, Kobayashi K, Shimano H,
Sone H (2016) Association of eating three meals irregularly with changes in BMI and weight among young
Japanese men and women: A 2-year follow-up. Physiol. Behav. 163: 81-87.
doi:10.1016/j.physbeh.2016.04.045
93. Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao XY, Toya N, Oya Y, Shikama A, Takarada A,
Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O,
Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK,
Shimano H (2016) KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.
Cell Reports 16(9): 2373-2386. doi:10.1016/j.celrep.2016.07.069
94. Saito Y, Ishii K, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K (2016) Loss of SDHB
Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.
Neurochem. Res. 41(4): 696-706. doi:10.1007/s11064-015-1738-3
95. Fujihara K, Hanyu O, Heianza Y, Suzuki A, Yamada T, Yokoyama H, Tanaka S, Yagyu H, Shimano H,
Kashiwagi A, Yamazaki K, Kawai K, Sone H (2016) Comparison of clinical characteristics in patients with type2
diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination
therapy by diabetes specialists. J. Diabetes Investig. 7(2): 260-269. doi:10.1111/jdi.12387
96. Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O,
Sone H (2016) Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2
diabetes mellitus. Diabetes-Metab. Res. Rev. 32(2): 178-186. doi:10.1002/dmrr.2680
97. Takeshima M, Ishikawa H, Shimizu T, Toyoshima A, Manabe M (2016) Lamotrigine-Induced DisseminatedIntravascular Coagulation With Anticonvulsant Hypersensitivity Syndrome: A Case Report. Psychosomatics
57(5): 540-542. doi:10.1016/j.psym.2016.02.009
98. Sekine A, Hozumi S, Shimizu T (2016) Influence of painful physical symptoms in the treatment ofJapanese patients with melancholic major depressive disorder: A prospective cohort study. Psychiatry Res.
242: 240-244. doi:10.1016/j.psychres.2016.05.053
99. He BK, Nohara K, Park N, Park YS, Guillory B, Zhao ZY, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH,
Chen Z (2016) The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms
and Protect against Metabolic Syndrome. Cell Metab. 23(4): 610-621. doi:10.1016/j.cmet.2016.03.007
100. Pagani L, Clair PAS, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M,
Castrillon G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie
B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM,
Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB (2016)
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating forsevere bipolar disorder. Proc. Natl. Acad. Sci. U.S.A. 113(6): E754-E761. doi:10.1073/pnas.1513525113
101. Miyai M, Hamada M, Moriguchi T, Hiruma J, Kamitani-Kawamoto A, Watanabe H, Hara-Chikuma M,
Takahashi K, Takahashi S, Kataoka K (2016) Transcription Factor MafB Coordinates Epidermal Keratinocyte
Differentiation. J. Invest. Dermatol. 136(9): 1848-1857. doi:10.1016/j.jid.2016.05.088
102. Huang CW, Hong TW, Wang YJ, Chen KC, Pei JC, Chuang TY, Lai WS, Tsai SH, Chu R, Chen WC, Sheen
LY, Takahashi S, Ding ST, Shen TL (2016) Ophiocordyceps formosana improves hyperglycemia anddepression-like behavior in an STZ-induced diabetic mouse model. BMC Complement. Altern. Med. 16(1): 310.
doi:10.1186/s12906-016-1278-7
103. Shawki HH, Kigoshi T, Katoh Y, Matsuda M, Ugboma CM, Takahashi S, Oishi H, Kawashima A (2016)
Identification, localization, and functional analysis of the homologues of mouse CABS1 protein in porcine
testis. Exp. Anim. 65(3): 253-265. doi:10.1538/expanim.15-0104

8

FY2016104. Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A,
Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M,
Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda
T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T,
Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S (2016) Aberrant PD-L1
expression through 3 '-UTR disruption in multiple cancers. Nature 534(7607): 402-406.
doi:10.1038/nature18294
105. Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD (2016) Lineageaffiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. J. Clin.
Invest. 126(3): 865-878. doi:10.1172/JCI83894
106. Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S,
Sugiyama F, Yagami KI, Takahashi S, Okuda A, Okazaki Y (2016) Combined Overexpression of JARID2,
PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced
Pluripotent Stem Cells. Stem Cells 34(2): 322-333. doi:10.1002/stem.2243
107. Sato H, Kubota N, Kubota T, Takamoto I, Iwayama K, Tokuyama K, Moroi M, Sugi K, Nakaya K, Goto M,
Jomori T, Kadowaki T (2016) Anagliptin increases insulin-induced skeletal muscle glucose uptake via an NOdependent mechanism in mice. Diabetologia 59(11): 2426-2434. doi:10.1007/s00125-016-4071-8
108. Obata A, Kubota N, Kubota T, Iwamoto M, Sato H, Sakurai Y, Takamoto I, Katsuyama H, Suzuki Y,
Fukazawa M, Ikeda S, Iwayama K, Tokuyama K, Ueki K, Kadowaki T (2016) Tofogliflozin Improves Insulin
Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice. Endocrinology 157(3):1029-1042. doi:10.1210/en.2015-1588
109. Ogata H, Kobayashi F, Hibi M, Tanaka S, Tokuyama K (2016) A novel approach to calculating the thermic
effect of food in a metabolic chamber. Physiol. Rep. 4: e12717. doi:10.14814/phy2.12717
110. Komori H, Kataoka K, Tanaka S, Matsuda N, Higuchi Y, Sakurai T (2016) Exogenous acetate ion reaches
the type II copper centre in CueO through the water-excretion channel and potentially affects the enzymatic
activity. Acta Crystallogr. F-Struct. Biol. Commun. 72(7): 558-563. doi:10.1107/S2053230X16009237
111. Seo D, Soeta T, Sakurai H, Setif P, Sakurai T (2016) Pre-steady-state kinetic studies of redox reactions
catalysed by Bacillus subtilis ferredoxin-NADP(+) oxidoreductase with NADP(+)/NADPH and ferredoxin.
Biochim. Biophys. Acta-Bioenerg. 1857(6): 678-687. doi:10.1016/j.bbabio.2016.03.005
112. Arulmozhiraja S, Matsuo N, Ishitsubo E, Okazaki S, Shimano H, Tokiwa H (2016) Comparative Binding
Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs - An Ab Initio Fragment Molecular Orbital
Study. PLoS One 11(11): e0166275 doi:10.1371/journal.pone.0166275
113. Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato, K, Hanyu
O, Sone H (2016) Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings ofgenome-wide association studies. Ann. Epidemiol. 26(11): 816-818. doi:10.1016/j.annepidem.2016.09.004
114. Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ,
Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A (2016) Mouse Tmem135
mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal
pathologies. eLife 5: e19264. doi:10.7554/eLife.19264
115. Huang GC, Zhang YF, Shan YL, Yang SZ, Chelliah Y, Wang H, Takahashi JS (2016) Circadian Oscillationsof NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells. J. Biol. Chem. 291(46):23906-23914. doi:10.1074/jbc.M116.728774
116. Qu ZP, Zhang H, Huang ML, Shi GS, Liu ZW, Xie PC, Li H, Wang W, Xu GQ, Zhang Y, Yang L, Huang GC,
Takahashi JS, Zhang WPJ, Xu Y (2016) Loss of ZBTB20 impairs circadian output and leads to unimodal
behavioral rhythms. eLife 5: e17171 doi:10.7554/eLife.17171

9FY2016117. Inoue A, Matsumoto I, Tanaka Y, Umeda N, Takai C, Kawaguchi H, Ebe H, Yoshida H, Matsumoto Y,
Segawa S, Takahashi S, Sumida T (2016) TIARP attenuates autoantibody-mediated arthritis via the
suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression. Sci Rep 6: 38684.
doi:10.1038/srep38684

2.) Review articles
118. Weber F, Dan Y (2016) Circuit-based interrogation of sleep control. Nature 538(7623): 51-59.
doi:10.1038/nature19773
119. Ishiguro H, Kodama S, Horikawa C, Fujihara K, Hirose AS, Hirasawa R, Yachi Y, Ohara N, Shimano H,
Hanyu O, Sone H (2016) In Search of the Ideal Resistance Training Program to Improve Glycemic Control andits Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Sports Med.
46(1): 67-77. doi:10.1007/s40279-015-0379-7

3.) Proceedings120. Green CB (2016) Circadian Post-transcriptional Control of Metabolism. Res. Perspect. End. Int. 41-50.
doi:10.1007/978-3-319-27069-2_5
121. Noguchi K, Ishida J, Ishimaru T, Kawasaki S, Kwon C, Kim JD, Kako K, Ohtsu H, Yamagata K, Fukamizu A(2016) HISTAMINE IS INVOLVED IN THE PATHOPHYSIOLOGY OF HEART AND KIDNEY DYSFUNCTIONS IN
MICE. Nephrol. Dial. Transplant. 31: i430. doi:10.1093/ndt/gfw188.27
122. Kobayakawa M, Okamura H, Yamagishi A, Morita T, Kawagoe S, Shimizu M, Ozawa T, Tsuneto S, Shima
Y, Miyashita M (2016) Family caregivers require mental health specialists for end-of-life psychosocial problems:
A nation-wide survey from the Japan Hospice and Palliative care Evaluation study (JHOPE2) Psycho-Oncol.
25(SP. S3): 51. doi:10.1002/pon.3982
123. Takahashi JS (2016) Molecular Architecture of the Circadian Clock in Mammals. Res. Perspect. End. Int.
pp. 13-24 doi: 10.1007/978-3-319-27069-2_2
124. Shimamoto S, Nakahata Y, Nakagawa Y, Fukuda Y, Aritake K, Urade Y, Hidaka Y (2016) Structural Analysis
of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J(2). Biophys. J. 110(3): 379A
doi:10.1016/j.bpj.2014.11.2792
125. Nakagawa Y, Shimamoto S, Fukuda Y, Maruno T, Kobayashi Y, Ohkubo T, Aritake K, Urade Y, Hidaka Y(2016) Isothermal Analysis of Interaction between Lipocalin-Type Prostaglandin D Synthase and Prostanoids.
Biophys. J. 110(3): 541A-542A doi.org/10.1016/j.bpj.2015.11.2899

4.) Other English articles
126. Azmahani A, Nakamura Y, Felizola SJA, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H,
Zouboulis CC, Aiba S, Sasano H (2016) Reply to comments to Letter to the Editor: comment on Azmahani etal. steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous
glands under normal and pathological conditions. J. Steroid Biochem. Mol. Biol. 155: 178-180.
doi:10.1016/j.jsbmb.2015.09.028
127. Matsuzaka T, Shimano H (2016) Novel role for the CRTC2 in lipid homeostasis. J. Diabetes Investig.
7(5): 677-679. doi:10.1111/jdi.12497
128. Green CB (2016) Cold cuts' added to the circadian smorgasbord of regulatory mechanisms Genes Dev.
30(17): 1909-1910. doi:10.1101/gad.289587.116

10