2022

List of Publications in 2022
WPI papers(1) Original Articles
1. Ikeda Y, Morita E, Muroi K, Arai, Y, Ikeda, T, Takahashi T, Shiraki N, Doki S, Hori D, Oi Y, Sasahara
S, Ishihara A, Matsumoto S, Yanagisawa M, Satoh M, Matsuzaki I (2022) Relationships between
sleep efficiency and lifestyle evaluated by objective sleep assessment: Sleep Epidemiology Project atUniversity of Tsukuba. Nagoya J. Med. Sci. 84(3):554-569. doi:10.18999/nagjms.84.3.554
2.

Fifel K, Deboer T (2022) Heterogenous electrophysiological responses of functionally distinct striatal
subregions to circadian and sleep-related homeostatic processes. Sleep 45(1).
doi:10.1093/sleep/zsab230

3.

Park I, Kokudo C, Seol J, Ishihara A, Zhang SM, Uchizawa A, Osumi H, Miyamoto R, Horie K, Suzuki
C, Suzuki Y, Okura T, Diaz J, Vogt KE, Tokuyama K (2022) Instability of non-REM sleep in older
women evaluated by sleep-stage transition and envelope analyses. Front. Aging Neurosci. 14.
doi:10.3389/fnagi.2022.1050648

4.

Hori D, Arai Y, Morita E, Ikeda Y, Muroi K, Ishitsuka M, Ikeda T, Takahashi T, Doki S, Oi Y, Sasahara
S, Ishihara A, Matsumoto S, Kanbayashi T, Yanagisawa M, Satoh M (2022) Morning preference isassociated with subjective happiness among Japanese female workers: A moderation analysis bysleepcharacteristics
from
the
SLEPT
study.
Chronobiol.
Int.
39(5):690-703.
doi:10.1080/07420528.2022.2028801

5.

Nemoto T, Irukayama-Tomobe Y, Hirose Y, Tanaka H, Takahashi G, Takahashi S, Yanagisawa M,
Kanbayashi T (2022) Effect of sevoflurane preconditioning on sleep reintegration after alteration by
lipopolysaccharide. J. Sleep Res. 31(5). doi:10.1002/advs.202203170

6.

Fifel K, Yanagisawa M, Deboer T (2022) Mechanisms of sleep/wake regulation underhypodopaminergic state: Insights from MitoPark mouse model of Parkinson's disease. Adv. Sci. 10(5).
doi:10.1002/advs.202203170

7.

Fujiyama T, Takenaka H, Asano F, Miyanishi K, Hotta-Hirashima N, Ishikawa Y, Kanno S, SeoaneCollazo P, Miwa H, Hoshino M, Yanagisawa M, Funato H (2022) Mice lacking cerebellar cortex andrelated structures show a decrease in slow-wave activity with normal non-REM sleep amount andsleep homeostasis. Front. Behav. Neurosci. 16. doi:10.3389/fnbeh.2022.910461

8.

Fifel K, El Farissi A, Cherasse Y, Yanagisawa M (2022) Motivational and valence-related modulationof sleep/wake behavior are mediated by midbrain dopamine and uncoupled from the homeostaticand circadian processes. Adv. Sci. 9(24). doi:10.1002/advs.202200640

9.

Han G, Matsumoto S, Diaz J, Greene RW, Vogt KE (2022) Dihydropyridine calcium blockers do notinterfere with non-rapid eye movement sleep. Front. Neurosci. 16. doi:10.3389/fnins.2022.969712

10. Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato
TA, Funato H, Yanagisawa M (2022) Metabolomic and pharmacologic analyses of brain substances
associated with sleep pressure in mice. Neurosci. Res. 177:16-24. doi:10.1016/j.neures.2021.11.008
11. Bjorness TE, Greene RW (2022) Arousal-mediated sleep disturbance persists during cocaine
abstinence in male mice. Front. Neurosci. 16. doi:10.3389/fnins.2022.868049
12. Xu JJ, Zhou R, Wang GD, Guo Y, Gao X, Zhou S, Ma CY, Chen L, Shi BH, Wang HY, Wang FC, Liu, Q(2022) Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinas5. Sleep
45(11). doi:10.1093/sleep/zsac198
13. Wang GD, Li Q, Xu JJ, Zhao S, Zhou R, Chen ZK, Jiang WT, Gao X, Zhou S, Chen ZY, Sun QZ, Ma
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CY, Chen L, Shi BH, Guo Y, Wang HY, Wang X, Li HY, Cai T, Wang YB, Chen ZN, Wang FC, Liu QH(2022) Somatic genetics analysis of sleep in adult mice. J. Neurosci. 42(28):5617-5640.
doi:10.1523/JNEUROSCI.0089-22.2022
14. Adachi M, Nagaura Y, Eto H, Kondo H, Kato C (2022) The impact of sleep-wake problems on healthrelated quality of life among Japanese nursing college students: a cross sectional survey. Health
Qual. Life Outcomes 20(1). doi:10.1186/s12955-022-02063-0
15. Miyazaki S, Kawano T, Yanagisawa M, Hayashi Y (2022) Intracellular Ca2+ dynamics in the ALA
neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans. iScience 25(6).
doi:10.1016/j.isci.2022.104452
16. Hasegawa E, Miyasaka A, Sakurai K, Cherasse Y, Li YL, Sakurai T (2022) Rapid eye movement sleep
is initiated by basolateral amygdala dopamine signaling in mice. Science 375(6584):994-1000.
doi:10.1126/science.abl6618
17. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T (2022) Effect of 12-week intake ofnicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese
adults:A
randomized,
double-blind
placebo-controlled
study.
Nutrients
14(4).
doi:10.3390/nu14040755
18. Zhou R, Wang GD, Li Q, Meng FX, Liu C, Gan R, Ju DP, Liao MM, Xu JJ, Sang D, Gao X, Zhou S, Wu
KJ, Sun QZ, Guo Y, Wu CY, Chen ZY, Chen L, Shi BH, Wang HY, Wang X, Li HY, Cai T, Li B, Wang
FC, Funato H, Yanagisawa M, Zhang EE, Liu QH (2022) A signalling pathway for transcriptional
regulation of sleep amount in mice. Nature 612(7940):519-527. doi:10.1038/s41586-022-05510-6
19. Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka
T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S,
Miyazaki, S, Tsuneoka, Y, Sugiyama, F, Takahashi, S, Hayashi, Y, Muratani, M, Liu, Q, Miyoshi, C,
Yanagisawa M, Funato H (2022) Kinase signalling in excitatory neurons regulates sleep quantity anddepth. Nature 612 (7940):512-518. doi:10.1038/s41586-022-05450-1
20. Chen ZK, Dong H, Liu CW, Liu WY, Zhao YN, Xu W, Sun X, Xiong YY, Liu YY, Yuan XS, Wang B,
Lazarus M, Cherasse Y, Li YD, Han F, Qu WM, Ding FF, Huang ZL (2022) A cluster of mesopontine
GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discov. 8(1):115.
doi:10.1038/s41421-022-00456-5
21. Tone D, Ode KL, Zhang QH, Fujishima H, Yamada RG, Nagashima Y, Matsumoto K, Wen ZQ, Yoshida
SY, Mitani TT, Arisato Y, Ohno R, Ukai-Tadenuma M, Garcon JY, Kaneko M, Shi, S, Ukai H, Miyamichi
K, Okada T, Sumiyama K, Kiyonari H, Ueda HR (2022) Distinct phosphorylation states of mammalian
CaMKII beta control the induction and maintenance of sleep. PLoS. Biol. 20(10).
doi:10.1371/journal.pbio.3001813
22. Uemura SI, Imanishi A, Terui Y, Park I, Satake M, Han G, Shioya T, Kanbayashi T, Nishino S (2022)
Residual effects of low dose of suvorexant, zolpidem, and ramelteon in healthy elderly subjects: A
randomized
double-blind
study.
Neuropsychopharmacol.
Rep.
42(3):288-298.
doi:10.1002/npr2.12262
23. Ogawa T, Kajiyama Y, Ishido H, Chiba S, Revankar GS, Nakano T, Taniguchi S, Kanbayashi T,
Ikenaka K, Mochizuki H (2022) Decreased cerebrospinal fluid orexin levels not associated with clinicalsleep disturbance in Parkinson's disease: A retrospective study. PLoS One 17(12).
doi:10.1371/journal.pone.0279747
24. Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H,
Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M (2022) OX2R-selective orexin
agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drugseeking behavior in mouse model of narcolepsy. PLoS One 17(7). doi:10.1371/journal.pone.0271901
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25. Korkutata M, Agrawal L, Lazarus M (2022) Allosteric modulation of adenosine A(2A) receptors as a
new therapeutic avenue. Int. J. Mol. Sci. 23(4):128-130. doi:10.3390/ijms23042101
26. Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H,
Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y,
Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T,
Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of
idiopathic hypersomnia in a Japanese population. Sleep Biol. Rhythms 20(1):137-148.
doi:10.1007/s41105-021-00349-2
27. Choi YJ, Nakamura Y, Akazawa N, Park, I, Kwak HB, Tokuyama K, Maeda S (2022) Effects ofnocturnal light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized
crossover trial. Chronobiol. Int. 39(4):602-612. doi:10.1080/07420528.2021.2014517
28. Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K,
Yanagisawa M, Vogt KE, Tokuda T, Sakurai T (2022) Optogenetic induction of hibernation-like statewithmodified
human
Opsin4
in
mice.
Cell
Reports
Methods2(11).
doi:10.1016/j.crmeth.2022.100336
29. Nagayama M, Aritake T, Hino H, Kanda T, Miyazaki T, Yanagisawa M, Akah, S, Murata N (2022)
Detecting cell assemblies by NMF-based clustering from calcium imaging data. Neural Netw. 149:2939. doi:10.1016/j.neunet.2022.01.023
30. Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A,
Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H,
Tanimura R, Yangisawa M, Nagase H (2022) Discovery of novel orexin receptor antagonists using a
1,3,5-trioxazatri-quinane bearing multiple effective residues (TriMER) library. Eur. J. Med. Chem.
240. doi:10.1016/j.ejmech.2022.114505
31. Miyagawa T, Tanaka S, Shimada M, Sakai N, Tanida K, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y,
Ogi K, Hiejima H, Kanbayashi T, Imanishi A, Ikegami A, Kamei Y, Hida A, Wada Y, Miyamoto M,
Takami M, Kondo H, Tamura Y, Taniyama Y, Omata N, Mizuno T, Moriya S, Furuya H, Kato M, Kato
K, Ishigooka J, Tsuruta K, Chiba S, Yamada N, Okawa M, Hirata K, Kuroda K, Kume K, Uchimura N,
Kitada M, Kodama T, Inoue Y, Nishino S, Mishima K, Tokunaga K, Honda M (2022) A rare genetic
variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia. npj Genom.
Med. 7(1). doi:10.1038/s41525-022-00298-w
32. Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura
N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H (2022) Discovery oforexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure:
Switching of receptor selectivity by chirality on the tetralin ring. Bioorg. Med. Chem. Lett. 60.
doi:10.1016/j.bmcl.2022.128555
33. Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper
HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli J (2022) Induced cognitive
impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model ofParkinson's disease. Adv. Sci. 9(10). doi:10.1002/advs.202103827
34. Tsuneoka Y, Atsumi Y, Makanae A, Yashiro M, Funato H (2022) Fluorescence quenching by highpower LEDs for highly sensitive fluorescence in situ hybridization. Front. Molec. Neurosci. 15.
doi:10.3389/fnmol.2022.976349
35. Yamada T, Shi S (2022) Estimating infection-related human mobility networks based on time series
data of COVID-19 infection in Japan. Appl. Sci.-Basel 12(18). doi:10.3390/app12189236
36. Iio K, Kutsumura N, Nagumo Y, Saitoh T, Tokuda A, Hashimoto K, Yamamoto N, Kise R, Inoue A,
Mizoguchi H, Nagase H (2022) Synthesis of unnatural morphinan compounds to induce itch-likebehaviors in mice: Towards the development of MRGPRX2 selective ligands. Bioorg. Med. Chem. Lett.
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56. doi:10.1016/j.bmcl.2021.128485
37. Hino T, Saitoh T, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y,
Tanimura R, Yanagisawa M, Nagase H (2022) Design and synthesis of novel orexin 2 receptor
agonists
basedonnaphthalene
skeleton.
Bioorg.
Med.
Chem.
Lett.
59.
doi:10.1016/j.bmcl.2022.128530
38. Katoh K, Kutsumura N, Yamamoto N, Nagumo Y, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y,
Tanimura R, Yanagisawa M, Nagase H (2022) Essential structure of orexin 1 receptor antagonist
YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nornalfurafine derivatives. Bioorg. Med. Chem. Lett. 59. doi:10.1016/j.bmcl.2022.128550
39. Moctezuma LA, Abe T, Molinas M (2022) Two-dimensional CNN-based distinction of human emotions
from EEG channels selected by multi-objective evolutionary algorithm. Sci. Rep 12(1).
doi:10.1038/s41598-022-07517-5
40. Shimazaki K, Sugimoto T, Toda H, Takahashi H (2022) A polyimide film-based simple force plate formeasuring the body mass of tiny insects. Sensors 22(21). doi:10.3390/s22218352
41. Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii KA, Tanaka T,
Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T (2022) Effects of eicosapentaenoic
acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans withdyslipidemia and type 2 diabetes. J. Diabetes Investig. 13(3):532-542. doi:10.1111/jdi.13699
42. Kawaminami A, Yamada D, Yanagisawa S, Shirakata M, Iio K, Nagase H, Saitoh A (2022) Selective
delta-opioid receptor agonist, KNT-127, facilitates contextual fear extinction via infralimbic cortex
and amygdala in mice. Front. Behav. Neurosci. 16. doi:10.3389/fnbeh.2022.808232
43. Omichi C, Kaminishi Y, Kadotani H, Sumi Y, Ubara A, Nishikawa K, Matsuda A, Ozeki Y (2022)
Limited social support is associated with depression, anxiety, and insomnia in a Japanese working
population. Front. Public Health 10. doi:10.3389/fpubh.2022.981592
44. Kitano M, Saitoh T, Nishiyama S, Einaga Y, Yamamoto T (2022) Electro-conversion of cumene into
acetophenone using boron-doped diamond electrodes. Beilstein J. Org. Chem. 18:1154-1158.
doi:10.3762/bjoc.18.119
45. Uenohara Y, Tsumura S, Hirayama S, Higashi E, Watanabe Y, Gouda H, Nagase H, Fujii H (2022)
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward delta andKappa opioid receptors. Bioorg. Med. Chem. 53. doi:10.1016/j.bmc.2021.116552
46. Okamura H, Yasugaki S, Suzuki-Abe H, Arai Y, Sakurai K, Yanagisawa M, Takizawa H, Hayashi Y(2022) Long-term effects of repeated social defeat stress on brain activity during social interactionin BALB/c mice. eNeuro 9(3). doi:10.1523/ENEURO.0068-22.2022
47. Shaikh SA, Kitagawa H, Matono A, Mariam K, Kim KS (2022) GeoFlink: An efficient and scalable
spatialdata
streammanagement
system.
IEEE
Access
10:24909-24935.
doi:10.1109/ACCESS.2022.3154063
48. Tao XX, Zhang R, Du RL, Yu TT, Yang H, Li JW, Wang YH, Liu Q, Zuo SK, Wang X, Lazarus M, Zhou
L, Wang BM, Yu Y, Shen YJ (2022) EP3 enhances adhesion and cytotoxicity of NK cells toward
hepatic stellate cells in a murine liver fibrosis model. J. Exp. Med. 219(5). doi:10.1084/jem.20212414
49. Sugimoto T, Kawasaki Y, Toda H, Takahashi H (2022) Measurement method of a microspringsupported force plate with an external laser displacement meter. Meas. Sci. Technol. 33(10).
doi:10.1088/1361-6501/ac7b12
50. Nakauchi Y, Nishinami S, Murakami Y, Ogura T, Kano H, Shiraki K (2022) Opalescence arising fromnetworkassemblyinantibody
solution.
Mol.
Pharm.
19(4):1160-1167.
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doi:10.1021/acs.molpharmaceut.1c00929
51. Katoh K, Yamamoto N, Ishikawa Y, Irukayama-Tomobe Y, Tanimura R, Saitoh T, Nagumo Y,
Kutsumura N, Yanagisawa M, Nagase H (2022) Effect of removal of the 14-hydroxy group on theaffinity of the 4,5-epox-ymorphinan derivatives for orexin and opioid receptors. Bioorg. Med. Chem.
Lett. 59. doi:10.1016/j.bmcl.2022.128527
52. Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi
T, Tanaka K, Yamada N (2022) Impairment of early neuronal maturation in anti-NMDA-receptor
encephalitis. Psychopharmacology 239(2):525-531. doi:10.1007/s00213-021-06036-x
53. Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H (2022)
Spectroscopic second and third harmonic generation microscopy using a femtosecond laser sourcein the third near-infrared (NIR-III) optical window. Biomed. Opt. Express 13(2):694-708
doi:10.1364/BOE.446273
54. Hinotsu K, Miyaji C, Yada Y, Kawai H, Sakamoto S, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K,
Takao S, Kishi Y, Takaki M, Yamada N (2022) The validity of atypical psychosis diagnostic criteria todetect anti-NMDA receptor encephalitis with psychiatric symptoms. Schizophr. Res. 248:292-299.
doi:10.1016/j.schres.2022.08.024
55. Yamada M, Kitagawa H, Amagasa T, Matono A (2022) Augmented lineage: traceability of data
analysis including complex UDF processing. VLDB J. doi:10.1007/s00778-022-00769-7
56. Yamauchi T, Yoshioka T, Yamada D, Hamano T, Ohashi M, Matsumoto M, Iio K, Ikeda M, Kamei M,
Otsuki T, Sato Y, Nii K, Suzuki M, Ichikawa H, Nagase H, Iriyama S, Yoshizawa K, Nishino S, Miyazaki
S, Saitoh A (2022) Cold-restraint stress-induced ultrasonic vocalization as a novel tool to measureanxiety in mice. Biol. Pharm. Bull. 45(3):268-275.
57. Li YD, Luo YJ, Chen ZK, Quintanilla L, Cherasse Y, Zhang LB, Lazarus M, Huang ZL, Song J (2022)
Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent
regulation of memory and anxiety-like behavior. Nat. Neurosci. 25(5):630–645. doi:10.1038/s41593022-01065-x
58. Yamazaki S, Inohara N, Ohmuraya M, Tsuneoka Y, Yagita H, Katagiri T, Nishina T, Mikami T, Funato
H, Araki K, Nakano H (2022) I kappa B zeta controls IL-17-triggered gene expression program inintestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies.
Mucosal Immunol. 15(8):1321-1337. doi:10.1038/s41385-022-00554-3
59. Tao XX, Du RL, Guo SM, Feng XL, Yu TT, OuYang Q, Chen QL, Fan XT, Wang XQ, Guo C, Li XZ, Xue
FX, Chen S, Tong MH, Lazarus M, Zuo SK, Yu Y, Shen YJ (2022) PGE(2)-EP3 axis promotes brown
adipose tissue formation through stabilization of WTAP RNA methyltransferase. Embo J. 41(16).
doi:10.15252/embj.2021110439
60. Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse
Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF,
Yamanaka A, Sakurai T, Ogawa S, Russo SJ (2022) Lateral habenula glutamatergic neurons
projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nat. Commun.
13(1):4089. doi:10.1038/s41467-022-31728-z
61. Horie K, Ota L, Miyamoto R, Abe T, Suzuki Y, Kawana F, Kokubo T, Yanagisawa M, Kitagawa H(2022) Automated sleep stage scoring employing a reasoning mechanism and evaluation of its
explainability. Sci. Rep. 12(1):12799. doi:10.1038/s41598-022-16334-9
62. Bou S, Kitagawa H, Amagasa T (2022) CPiX: Real-time analytics over out-of-order data streams byincremental sliding-window aggregation. IEEE Transactions on Knowledge and Data Engineering
34(11):5239-5250. doi:10.1109/TKDE.2021.3054898
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63. Miura K, Kobayashi R, Amagasa T, Kitagawa H, Fujita N, Boku T (2022) An FPGA-based accelerator
for regular path queries over edge-labeled graphs. Proc. IEEE BigData2022:415-422.
doi:10.1109/BigData55660.2022.10020406
64. Takdir, Kitagawa H, Amagasa T (2022) Region-based sub-snapshot (RegSnap): Enhanced fault
tolerance in distributed stream processing with partial snapshot. Proc. 7th Workshop on Real-time
Stream Analytics, Stream Mining, CER/CEP & Stream Data Management in Big Data:3374-3382.
doi:10.1109/BigData55660.2022.10020607
65. Shaikh S A, Kitagawa H, Matono A, Kim K S (2022) TStream: A framework for real-time and scalable
trajectorystreamprocessing
andanalysis.
Proc.
ACM
SIGSPATIAL
2022:30.
doi:10.1145/3557915.3560964
66. Seol J, Lee J, Park I, Tokuyama K, Fukusumi S, Kokubo T, Yanagisawa M, Okura T (2022)
Bidirectional associations between physical activity and sleep in older adults: a multilevel analysis
using polysomnography. Sci. Rep. 12(1):15399. doi:10.1038/s41598-022-19841-x
67. Uchizawa A, Funayama A, Osumi H, Enomoto Y, Zhang S, Tokuyama K, Omi N, Sagayama H (2022)
Food quotient assessments using one-week dietary records and food frequency questionnaires ofyoung Japanese runners. J. Nutr. Sci. Vitaminol. 68(1):47-54. doi: 10.3177/jnsv.68.47
68. Koyama K, Ito MK, Sakaguchi M, Ohnishi T (2022) Classification of power spectra of EEG by nonnegative matrix factorization. Technical Report of IEICE 121:111-116.
69. Koyanagi I, Tezuka T, Yu J, Srinivasan S, Naoi T, Yasugaki S, Nakai A, Taniguchi S, Hayashi Y,
Nakano Y, Sakaguchi M (2022) Fully automatic REM sleep stage-specific intervention systems using
single EEG in mice. Neurosci. Res. 186:51-58. doi:10.1016/j.neures.2022.10.001
70. Funato H, Yanagisawa M (2022) Hunt for mammalian sleep-regulation genes. Brain Sci. Adv.
8(3):173–182. doi:10.26599/BSA.2022.9050012
71. Ando T, Wakai M, Kanbayashi T, Katsuno M (2022) Status cataplecticus with rapid eye movement
sleep excess in late-onset narcolepsy type 1. Intern. Med. 61(19):2951-2955.
doi:10.2169/internalmedicine.8465-21(2) Review articles
72. Nagase H (2022) Research and development of morphinan derivatives for drug. THE CHEMICALTIMES 264(2):2-8.
73. Saitoh T (2022) Discovery of OX1R specific antagonists bearing morphinan skeleton. THE CHEMICALTIMES 264(2):9-15.
74. Nagumo Y (2022) Creation of a novel κ opioid analgesic based on an active conformation of
nalfurafine. THE CHEMICAL TIMES 264(2):16-19.
75. Kumar VM, Kumar D, Mallick HN, Gulia KK (2022) Capsaicin receptors in sleep regulation. Sleep andVigilance 6:41-49. doi:https://doi.org/10.1007/s41782-022-00193-5(3) Proceedings
76. Bou S, Amagasa T, Kitagawa H (2022) InTrans: Fast incremental transformer for time series data
prediction. Lecture Notes in Computer Science 13427:47-61. doi:10.1007/978-3-031-12426-6_4
77. Khalique, V, Kitagawa, H (2022) BPF: An effective cluster boundary points detection technique.
Lecture Notes in Computer Science 13426:404-416. doi:10.1007/978-3-031-12423-5_31

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78. Bou S, Amagasa T, Kitagawa H, Shaikh S A (2022) PR-MVI: Efficient missing value imputation overdata streams by distance likelihood. Lecture Notes in Computer Science 13635:338-351.
doi:10.1007/978-3-031-12423-5_31
79. Yamada M, Kitagawa H, Shaikh S A, Amagasa T, Matono A (2022) Streaming augmented lineage:
traceability of complex stream data analysis. Proc. iiWAS2022. Lecture Notes in Computer Science
13635:224-236. doi:10.1007/978-3-031-21047-1_20
80. Stenwig H. Soler A, Furuki J, Suzuki Y, Abe T, Molinas M (2022) Automatic sleep stage classification
with optimized selection of EEG channels," 21st IEEE International Conference on Machine Learning
and Applications (ICMLA) :1708-1715. doi:10.1109/ICMLA55696.2022.00262.
(4) Other English Articles
81. Shoi Shi (2022) Social sleep alteration in ants. J. Sleep Res. 31.
82. Nemoto T, Irukayama-Tomobe Y, Hirose Y, Takahashi S, Takahashi G, Tanaka H, Yanagisawa M,
Kanbayashi T (2022) Sevoflurane preconditioning promotes sleep reintegration fromlipopolysaccharide induced shattered sleep. Sleep 45:A66-A67.
83. Tsujino, N, Ikeda, M, Hirano, A, Sakurai, T (2022) Editorial: The role of neuropeptides insleep/wakefulness
statesandthecircadianclock.
Front.
Neurosci.
16.
doi:10.3389/fnins.2022.913371
84. Miyazaki S, Yoshizawa K, Kodama T, Ishido H, Imanishi A, Kashiwagi M, Sasajima T, Shimizu S,
Chiba S, Han G, Fukusumi S, Kondo H, Hayashi Y, Kanbayashi T, Kimura M (2022) Relationships
among sleep regulatory neuropeptides in cerebrospinal fluid of patients with hypersomnia. J. Sleep
Res. 31.
85. Ohba A, Sakaguchi M (2022) Contribution of adult-born neurons to memory consolidation during
rapid eye movement sleep. Neural Regen. Res. 17(2):307-308. doi:10.4103/1673-5374.317966
86. Chiba S, Han G, Kanbayashi T (2022) Large arachnoid cysts and hypersomnolence: Symptomatic or
not? Neural Regen. Res. 45:A364-A364.
87. Uchida T, Matsuzawa D, Sawada D, Kanbayashi T, Fujii K (2022) Two cases of Kleine-Levin syndrome
with good responses to lithium treatment at low serum levels. Pediatr. Int. 64(1).
doi:10.1111/ped.15103
88. Komagamine T, Kanbayashi T, Suzuki K, Hirata K, Nishino S (2022) Atypical psychoses and antiNMDA receptor encephalitis: A review of literature in the mid-twentieth century. Psychiatry Clin.
Neurosci. 76(2):62-63. doi:10.1111/pcn.13317
89. Sugimoto T, Toda H, Takahashi H (2022) 3D printed micro force plate for measuring the groundreaction force of a fruit fly. IEEE 35th International Conference on Micro Electro Mechanical Systems.
doi:10.1109/MEMS51670.2022.9699472
90. Miyazaki T, Williams JA, Toda H (2022) Measuring sleep in drosophila. Behavioral Neurogenetics :3956. doi:10.1007/978-1-0716-2321-3_4
91. Lazarus M, Oishi Y, Landolt HP (2022) Chapter 45 - Adenosinergic control of sleep. In: Principles andpractice of sleep medicine (seventh edition), eds. M. Kryger, T. Roth & W.C. Dement. Elsevier:452459.
92. Yamamoto T, Saitoh T (2022) Electro-organic synthesis. Einaga Y (ed.), Diamond electrodes.
Springer Nature Singapore Pte Ltd.:177-195.

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WPI-related papers(1) Original articles
93. Zamarbide M, Martinez-Pinilla E, Gil-Bea F, Yanagisawa M, Franco R, Perez-Mediavilla A (2022)
Genetic inactivation of free fatty acid receptor 3 impedes behavioral deficits and pathologicalhallmarks in the APP(swe) Alzheimer's disease mouse model. Int. J. Mol. Sci. 23(7).
doi:10.3390/ijms23073533
94. Inoue Y, Liao CW, Tsunakawa Y, Tsai IL, Takahashi S, Hamada M (2022) Macrophage-specific, Mafbdeficient mice showed delayed skin wound healing. Int. J. Mol. Sci. 23(16).
doi:10.3390/ijms23169346
95. Deng ZB, Kuno A, Ojima M, Takahashi S (2022) MafB maintains beta-Cell identity under MafAdeficient conditions. Mol. Cell. Biol. 42(8). doi:10.1128/mcb.00541-21
96. Samir O, Kobayashi N, Nishino T, Siyam M, Yadav MK, Inoue Y, Takahashi S, Hamada M (2022)
Transcription factor MAFB as a prognostic biomarker for the lung adenocarcinoma. Int. J. Mol. Sci.
23(17). doi:10.3390/ijms23179945
97. Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M,
Matsuzaka T, Sone H, Shimano H (2022) Hepatocyte- or macrophage-specific SREBP-1a deficiency
in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.
Am. J. Physiol.-Gastroint. Liver Physiol.s 323(6):G627-G639. doi:10.1152/ajpgi.00090.2022
98. Furuta Y, Yatoh S, Iwasaki H, Sugano Y, Sekiya M, Suzuki H, Shimano H (2022) L-asparaginaseinduced continuous hyperglycemia with type 1 diabetes-related antibodies and HLA genotypes: A
case study. Cureus. J. Med. Sci. 14(10). doi:10.7759/cureus.30067
99. Hashimoto M, Takeichi K, Murata K, Kozakai A, Yagi A, Ishikawa K, Suzuki-Nakagawa C, Kasuya Y,
Fukamizu A, Nakagawa T (2022) Regulation of neural stem cell proliferation and survival by protein
arginine methyltransferase 1. Front. Neurosci. 16. doi:10.3389/fnins.2022.948517
100. Suzuki Y, Suzuki H, Ishikawa T, Yamada Y, Yatoh S, Sugano Y, Iwasaki H, Sekiya M, Yahagi N, Hada
Y, Shimano H (2022) Exploratory analysis using machine learning of predictive factors for falls intype 2 diabetes. Sci. Rep. 12(1). doi:10.1038/s41598-022-15224-4
101. Ikeda T, Hori D, Sasaki H, Komase Y, Doki S, Takahashi T, Oi Y, Ikeda Y, Arai Y, Muroi K, Ishitsuka
M, Matsuura A, Go W, Matsuzaki I, Sasahara S (2022) Prevalence, characteristics, and psychologicaloutcomes of workplace cyberbullying during the COVID-19 pandemic in Japan: a cross-sectional
online survey. BMC Public Health 12(1). doi:10.1186/s12889-022-13481-6
102. Hori D, Oi Y, Doki S, Takahashi T, Ikeda T, Ikeda Y, Arai Y, Muroi K, Sasaki H, Ishitsuka M, Matsuura
A, Go W, Matsuzaki I, Sasahara S (2022) Ibaraki's Amabie-chan usage and its association with
infection prevention behavior and fear of COVID-19: a cross-sectional preliminary survey of the
Tsukuba Salutogenic Occupational Cohort Study. Environ. Health Prev. 27. doi:10.1265/ehpm.2200052
103. Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi S, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone
H, Shimano H, Nakagawa Y (2022) Wogonin, a compound in scutellaria baicalensis, activates ATF4FGF21 signaling in mouse hepatocyte AML12 cells. Nutrients 14(19). doi:10.3390/nu14193920
104. Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han
SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y,
Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H (2022) Morphological and functional
adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.
Biochim. Biophys. Acta-Mol. Basis Dis. 1868(4). doi:10.1016/j.bbadis.2022.166339

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105. Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S,
Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani
KI, Ema M (2022) Essential roles of exocyst complex component 3-like 2 on cardiovasculardevelopment in mice. Life-Basel 12(11). doi:10.3390/life12111730
106. Okuda S, Nakayama T, Uemura N, Hikawa R, Ikuno M, Yamakado H, Inoue H, Tachibana N, Hayashi
Y, Takahashi R, Egawa N (2022) Striatal-inoculation of α-synuclein preformed fibrils aggravated thephenotypes of REM sleep without atonia in A53T BAC-SNCA transgenic mice. Int. J. Mol.
Sci. 23(21):13390. doi:10.3390/ijms232113390
107. Li F, Matsumori S, Egawa N, Yoshimoto S, Yamashiro K, Mizutani H, Uchida N, Kokuryu A, Kuzuya A,
Kojima R, Hayashi Y, Takahashi R (2022) Predictive diagnostic approach to dementia and dementia
subtypesusing
wirelessandmobileelectroencephalography-A
pilot
study.
Bioelectricity. doi.org/10.1089/bioe.2021.0030
108. Tsuneki H, Maeda T, Takata S, Sugiyama M, Otsuka K, Ishizuka H, Onogi Y, Tokai E, Koshida C, Kon
K, Takasaki I, Hamashima T, Sasahara M, Rudich A, Koya D, Sakurai T, Yanagisawa M, Yamanaka
A, Wada T, Sasaoka T (2022) Hypothalamic orexin prevents non-alcoholic steatohepatitis andhepatocellular carcinoma in obesity. Cell Rep. 41(3):111497. doi: 10.1016/j.celrep.2022.111497
109. Islam Md Tarikul, Rump F, Tsuno Y, Kodani S, Sakurai T, Matsui A, Maejima T, Mieda M (2022)
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateralhypothalamicorexinneurons.
Curr.
Biol.
S0960-9822(22)01121-6.
doi:10.1016/j.cub.2022.07.020
110. Xu J, Zhou R, Wang G, Guo Y, Gao X, Zhou S, Ma C, Chen L, Shi B, Wang H, Wang F, Liu Q (2022)
Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase. Sleep
45(11):zsac198 doi:10.1093/sleep/zsac198
111. He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang
H (2022) Mitochondrial cristae architecture projects against mtDNA release and inflammation. Cell
Rep. 41(10):111774. doi:10.1016/j.celrep.2022.111774
112. Liu J, Fujii Y, Fujii K, Seol J, Kim M, Tateoka K, Nagata K, Zhang H, Okura T (2022) Pre-frailty
associated with traffic crashes in Japanese community-dwelling older drivers. Traffic Inj. Prev.
23(2):73-78. doi:10.1080/15389588.2022.2030473
113. Nagata K, Tsunoda K, Fujii Y, Tsuji T, Okura T (2022) Physical activity intensity and suspected
dementia in older Japanese adults: a dose-response analysis based on an 8-year longitudinal study.
Journal of Alzheimer’s Disease 87(3):1055-1064. doi:10.3233/JAD-220104
114. Gan SR, Low K, Okura T, Kawabata M (2022) Short-term effects of square stepping exercise on
cognitive and social functions in sedentary older adults: A home-based online trial. ACPES Journal of
Physical Education, Sport, and Health 2(2):70-77. doi:10.15294/ajpesh.v2i2.62184
115. Fujii K, Fujii Y, Kubo Y, Tateoka K, Liu J, Nagata K, Nakashima D, Okura T (2022) Frail older adults
without occupational dysfunction maintain good subjective well-being: a cross-sectional study.
Healthcare 10(10):1922. doi:10.3390/healthcare10101922
116. Shoji T, Fujii Y, Tateoka K, Tsuji T, Okura (2022) The association of the Japan Science andTechnology Agency Index of Competence with physical and cognitive function in community-dwellingolder adults. Geriatrics & Gerontology International, 22(9):753-758.
117. Yoon J, Isoda H, Ueda T. Okura T (2022) Cognitive and physical benefits of a game-like dual-task
exercise among the oldest nursing home residents in Japan. Alzheimer’s & Dementia-Translational
Research & Clinical Interventions 8(1):e12276. doi:10.1002/trc2.12276
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118. Katori M, Shi S, Ode KL, Tomita Y, Ueda HR (2022) The 103,200-arm acceleration dataset in the UK
Biobank revealed a landscape of human sleep phenotypes. Proc. Natl. Acad. Sci. U.S.A. 119(12):e2116729119. doi:10.1073/pnas.2116729119
119. Komagamine T, Kanbayashi T, Suzuki K, Hirata K, Nishino S (2022) "Atypical psychoses" and antiNMDA receptor encephalitis: A review of literature in the mid-twentieth century. Psychiatry Clin.
Neurosci. 76(2):62-63. doi:10.1111/pcn.13317(4) Other English Articles
120. Yanagawa T, Hirayama A, Osada K, Kuno A, Takahashi S (2022) Sufficient liver erythropoietin
synthesis is induced in hemodialysis patients not requiring erythropoiesis-stimulating agents. Clin.
Nephrol. 98(3):167-170. doi:10.5414/CN110749

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