Nomenclature file from goRENI, version 3.19 as of 10-Jun-2024
Organ Working Group
OrgansRespiratory System
Nasal cavity
Respiratory System
Nasal cavity

LesionCleft palate
Deviation, nasal septum

Respiratory System

Nasal cavity

Perforation, septum

Respiratory System
Respiratory System
Respiratory System

Nasal cavity
Nasal cavity
Nasal cavity

AtrophyDegeneration
Eosinophilic globules

Respiratory System
Respiratory System
Respiratory System
Respiratory System

Nasal cavity
Nasal cavity
Nasal cavity
Nasal cavity

Corpora amylacea
Amyloid
Necrosis
Erosion/ulcer

Respiratory System
Respiratory System

Nasal cavity
Nasal cavity

Regeneration
Inflammation

Respiratory System

Nasal cavity; Paranasal sinus;
Infiltrate
Nasopharynx; Larynx; Trachea;
Bronchi; Lung: Bronchioles;
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura

Respiratory System

Nasal cavity; Trachea; Bronchi;
Lung: Bronchioles
Nasal cavity
Nasal cavity
Nasal cavity
Nasal cavity

Respiratory System
Respiratory System
Respiratory System
Respiratory System

Epithelial attenuation
Congestion
Edema
Hemorrhage
Angiectasis

Modifier(s)Acute; Chronic; Chronic active;
Granulomatous; Lymphocytic or
eosinophilic
Type of inflammatory cell that
represents the predominant cell
type in the infiltrate:
Lymphocyte; Plasma cell; Mast
cell; Monocyte/macrophage;
Mononuclear; Neutrophil;
Eosinophil; Basophil; Mixed

Synonym

StatusPublished
Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Published
Published
Published
Modified after
publication
Published
Modified after
publication
Added after
publication

Added after
publication
Published
Published
Published
PublishedOrgan Working GroupRespiratory System

OrgansNasal cavity

LesionThrombus

Respiratory System

Metaplasia, squamous cell

Respiratory System

Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity

Metaplasia, respiratory,
olfactory/glandular epithelium

Published

Respiratory System
Respiratory System

Nasal cavity
Nasal cavity

Published
Published

Respiratory System

Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity

Hyperplasia, squamous cell
Hyperplasia, transitional
epithelium
Hyperplasia, respiratory
epithelium
Hyperplasia/metaplasia,
mucous cell
Hyperplasia, olfactory
epithelium
Hyperplasia, basal cell
Hyperplasia, neuroendocrine
cell
Hyperplasia, atypicalPublished

Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System

Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx
Nasal cavity; Paranasal sinus;
Nasopharynx

Modifier(s)Synonym

StatusModified after
publication
Published

Published
Published
Published
Published

Papilloma, squamous cell

Modified after
publication
Published

AdenomaPublished

Carcinoma, squamous cell

Published

Carcinoma, adenosquamous

Published

Adenocarcinoma

PublishedOrgan Working GroupRespiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System

OrgansNasal cavity; Paranasal sinus;
Nasopharynx
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi

LesionCarcinoma, neuroepithelium
Degeneration

StatusModified after
publication
Published

Necrosis

Published

Erosion/ulcer

Modified after
publication
Modified after
publication
Published

Ectasia, submucosal gland

Larynx; Trachea; Bronchi; Lung: Regeneration
Bronchioles
Larynx; Trachea; Bronchi; Lung: Inflammation
Bronchioles
Bronchi; Lung: Bronchioles
Bronchiectasis
LarynxLarynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles

Modifier(s)Epithelial alteration
Metaplasia, squamous cell

Modified after
publication
Modified after
publication
Published
Published

Hyperplasia, squamous cell

Published

Hyperplasia, respiratory
epithelium
Hyperplasia, mucous cell

Modified after
publication
Published

Hyperplasia, neuroendocrine
cell
Hyperplasia, atypicalPublished

Papilloma

Acute; Granulomatous; Chronic;
Chronic active

Synonym

Modified after
publication
PublishedOrgan Working GroupRespiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System

Respiratory System

OrgansLarynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Larynx; Trachea; Bronchi; Lung:
Bronchioles
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura

LesionTumor, neuroendocrine cell,benignCarcinoma, squamous cell

Lung: Terminal bronchioles;
Lung: Alveoli; Pleura

Fibrosis

Modifier(s)Synonym

StatusPublished
Published

Adenocarcinoma

Published

Tumor, neuroendocrine cell,malignantCyst, congenital

Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published

Hypoplasia
Degeneration
Necrosis
Regeneration
Macrophages, increased
Lipoproteinosis, alveolus
Pigment/foreign material
Inflammation

Acute alveolar/interstitial;
Chronic interstitial; Acutebronchioloalveolar; Chronic
bronchioloalveolar;
Granulomatous

Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication

Modified after
publication

Organ Working GroupRespiratory System

OrgansLung: Alveoli

LesionEctasia, acinus

Respiratory System

Lung: Alveoli

Emphysema, alveolus

Respiratory System

Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli; Pleura
PleuraAtelectasis

Metaplasia, mucous cell

Respiratory System
Respiratory System

Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
PleuraLung: Alveoli

Respiratory System

Lung: Alveoli

Epithelioma, cystic, keratinizing

Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System

Modifier(s)Hemorrhage

StatusModified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published

Congestion
Edema
Embolus
Hypertrophy, media, artery
Mineralization
Effusion, noninflammatory

Metaplasia, squamous cell
Hyperplasia, bronchioloalveolar
Hyperplasia, mesothelium
Cyst, keratinizing

Synonym

Alveolar; Bronchiolar(bronchiolization); Mixed

Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication

Organ Working GroupRespiratory System

OrgansLung: Alveoli

LesionEpithelioma, nonkeratinizing

Modifier(s)Respiratory System

Adenoma, bronchiolo-alveolar

Solid; Papillary; Mixed; Alveolar;
TubularHepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung: Terminal bronchioles;
Lung: Alveoli
Lung; Lung: Bronchioles; Lung:
Terminal bronchioles; Lung:
Alveoli
Liver
Liver
Liver
Liver

Hepatobiliary System
Hepatobiliary System

Liver
Liver

Mineralization
Pigment

Hepatobiliary System
Hepatobiliary System

Liver
Liver

Hepatobiliary System

Liver

Crystals
Inclusions, intranuclear andcytoplasmic
Hypertrophy, hepatocyte

Hepatobiliary System

Liver

Atrophy, hepatocyte

Hepatobiliary System

Liver

Cytoplasmic alteration

Respiratory System
Respiratory System
Respiratory System
Respiratory System
Respiratory System

Carcinoma, bronchiolo-alveolar
Carcinoma, acinar
Carcinoma, adenosquamous
Carcinoma, squamous cell

Non-keratinizing; Keratinizing

Material, extracellular [insert
morphology/color]
Hepatodiaphragmatic nodule
Fatty change
Phospholipidosis
Amyloid

Lipofuscin; Iron/hemosiderin;
Porphyrin; Bile (cholestasis)

Synonym

StatusModified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Added after
publication
Published
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Modified after
publication
Modified after
publication
PublishedOrgan Working Group
Hepatobiliary System

OrgansLiver

LesionRarefaction

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Liver
Liver
Liver

Degeneration, hydropic
Degeneration, cystic
Single cell necrosis

Hepatobiliary System
Hepatobiliary System

Liver
Liver

Necrosis, focal/multifocal
Necrosis, zonal

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Karyocytomegaly and/or
multinucleated hepatocytes
Cyst, bile duct

Hepatobiliary System

Liver

Infiltrate, neutrophil

Hepatobiliary System

Liver

Infiltrate, mononuclear cell

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Infiltrate, mixed inflammatory
cell
Infiltrate, peribiliary

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Liver
Liver
Liver
Liver

Fibrosis
Helicobacter sp. hepatitis
Murine norovirus hepatitis
Mouse hepatitis virus hepatitis

Hepatobiliary System

Liver

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Liver
Liver
Liver

Tyzzer's disease (Clostridium
piliforme infection)
Congestion
Angiectasis
Thrombus

Modifier(s)Centrilobular; Midzonal;
Periportal; Diffuse

Synonym

StatusAdded after
publication
Published
Published
Modified after
publication
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published

Cystic; Cavernous

Published
Published
Modified after
publication

Organ Working Group
Hepatobiliary System

OrgansLiver

LesionInfarct

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Hypertrophy/karyomegaly,
endothelial cell
Hyperplasia,
hemangioendothelial
Focus of cellular alteration

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Hepatobiliary System
Hepatobiliary System

Liver
Liver

Hyperplasia, hepatocyte, nonregenerative
Hyperplasia, hepatocyte,
regenerative
Hypertrophy/hyperplasia,
Kupffer cell
Hyperplasia, Ito cell
Hyperplasia, bile duct

Hepatobiliary System
Hepatobiliary System

Liver
Liver

Cholangiofibrosis
Hyperplasia, oval cell

Hepatobiliary System

Liver

Adenoma, hepatocyte

Hepatobiliary System

Liver

Carcinoma, hepatocyte

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Liver
Liver
Liver
Liver

Hepatoblastoma
Cholangioma
Cholangiocarcinoma
Adenoma,hepatocholangiocellular

Modifier(s)Amphophilic; Basophilic,diffuse; Basophilic, tigroid;
Basophilic, NOS; Basophilic;
Mixed cell; Clear cell;
Eosinophilic

Synonym

StatusModified after
publication
Modified after
publication
Modified after
publication
Published

Modified after
publication
Modified after
publication
Published

CysticAcinar; Solid; Trabecular;
Adenoid
Simple; Cystic

Published
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Published
PublishedOrgan Working Group
Hepatobiliary System

OrgansLiver

LesionModifier(s)Carcinoma,
hepatocholangiocellular
Tumor, Ito cell, benign
Histiocytic sarcoma
Hemangioma
Capillary type; Cavernous type
Hemangiosarcoma
Extramedullary hematopoiesis
Intrahepatocellular erythrocytes

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Hepatobiliary System

Liver
Liver
Liver
Liver
Liver
Liver

Hepatobiliary System

Liver

Hepatobiliary System

Liver

Hepatobiliary System
Hepatobiliary System

Liver
Gallbladder

Metaplasia, pancreatic acinar
cell
Metaplasia, glandular,
hepatocyte
Intravascular hepatocytes
Ectopic tissue, hepatocytes

Hepatobiliary System

Gallbladder

Ectopic tissue, pancreas

Hepatobiliary System
Hepatobiliary System

GallbladderGallbladder

Hyalinosis
Metaplasia, glandular

Hepatobiliary System

GallbladderCalculus

Hepatobiliary System

Gallbladder

Inflammation

Hepatobiliary System
Hepatobiliary System
Hepatobiliary System
Urinary System

GallbladderGallbladderGallbladder
KidneyHyperplasia
Adenoma
Adenocarcinoma
Ectopic tissue, adrenal

Urinary System

KidneyAplasia

Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Published
Modified after
publication
Modified after
publication

Organ Working GroupUrinary System
Urinary System

OrgansKidneyKidneyLesionHypoplasia
Renal dysplasia

Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyAtrophy, tubule
Degeneration, tubule
Single cell necrosis

Urinary System
Urinary System

KidneyKidneyNecrosis
Necrosis, papilla

Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyKidneyKidneyInfarct
Hemorrhage
Vacuolation
Accumulation, glycogenAccumulation, hyaline droplets

Urinary System
Urinary System

KidneyKidneyAlpha2u-globulin nephropathy
Dilatation, tubule

Urinary System
Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyKidneyUrinary System

KidneyCyst
Nephropathy, retrograde
Basophilia, tubule
Chronic progressive
nephropathy (CPN)Cast

Urinary System

KidneyUrinary System
Urinary System

KidneyKidneyAccumulation, adipocytes,
interstitial
Crystals
Nephropathy, obstructive

Modifier(s)Synonym

StatusPublished
Modified after
publication
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published

Hyaline; Granular

Modified after
publication
Modified after
publication
Published
PublishedOrgan Working GroupUrinary System

OrgansKidney; Renal pelvis

LesionMineralization

Urinary System
Urinary System

KidneyKidneyMetaplasia, osseous
Pigment

Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyInclusion bodies
Basophilic granules
Amyloid, interstitial

Urinary System
Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyKidneyRegeneration, tubule
Karyomegaly
Hypertrophy, tubule
Glomerulonephritis

Urinary System
Urinary System

KidneyKidneyUrinary System
Urinary System
Urinary System

KidneyKidneyKidneyGlomerulopathy, hyaline
Glomerulopathy,
mesangioproliferative
Glomerulosclerosis
Mesangiolysis
Amyloid, glomerular

Urinary System

KidneyAtrophy, glomerulus

Urinary System

KidneyDilatation, Bowman's space

Urinary System

KidneyUrinary System

KidneyMetaplasia/hyperplasia,
Bowman's capsule
Hyperplasia, mesangium

Urinary System

KidneyInfiltrate, inflammatory cell,interstitium

Modifier(s)SynonymTubule; Intraluminal; Basement
membrane; Interstitial

Membranoproliferative;
Crescentic

StatusPublished

Published
Modified after
publication
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
PublishedOrgan Working GroupUrinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

OrgansKidneyKidneyKidneyKidney; Renal pelvis
KidneyKidneyLesionInterstitial nephritis
Microabscess
Edema, interstitial
Pyelonephritis
Fibrosis, interstitial
Inflammation, interstitial

Modifier(s)Urinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyKidneyKidneyKidneyHyperplasia, tubule
Simple; AtypicalHyperplasia, oncocytic
Extramedullary hematopoiesis
Hyperplasia, juxtaglomerular
Adenoma
Amphophilic vacuolar adenoma

Urinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

KidneyKidneyKidneyKidneyKidneyKidneyUreter

Oncocytoma
Carcinoma
Nephroblastematosis
Nephroblastoma
Renal mesenchymal tumor
Renal sarcoma
Aplasia, ureter

Urinary System

Renal pelvis

Dilatation, pelvis

Urinary System

UreterDilatation

Urinary System
Urinary System
Urinary System

Renal pelvis; Ureter; Urethra
Renal pelvis; Urinary bladderRenal pelvis; Urinary bladder

Infiltrate, inflammatory cell
Erosion
Ulcer

Urinary System
Urinary System

Urinary bladder
Urinary bladderVacuolation, urothelium
Inclusions, urothelium

Synonym

StatusPublished
Published
Published
Published
Published
Added after
publication
Published
Published
Published
Published
Published
Added after
publication
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Published
PublishedOrgan Working GroupUrinary System

LesionCalculus

Urinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

OrgansRenal pelvis; Ureter; Urinary
bladder
Renal pelvis; Ureter; Urinary
bladder
Urinary bladder
Urinary bladder
Urinary bladder
Urinary bladder
Urinary bladder
Urinary bladder

Urinary System
Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

Urinary bladder
Urinary bladder
Urinary bladder
Urinary bladder
Urinary bladder; Urethra
Urinary bladder

Mineralization
Uropathy, obstructive
Diverticulum
Hypertrophy, urothelium
Proteinaceous plug
Parasite, nematode

Urinary System
Urinary System
Urinary System

UrethraUrethraRenal pelvis; Ureter; Urinary
bladder; Urethra
Renal pelvis; Ureter; Urinary
bladder; Urethra
Ureter; Urinary bladder;
UrethraUreter; Urinary bladder;
UrethraRenal pelvis; Ureter; Urinary
bladder; Urethra
Renal pelvis; Ureter; Urinary
bladder; Urethra

Obstruction
Infiltrate, inflammatory cell
Hyperplasia, urothelium

Urinary System

Urinary System
Urinary System
Urinary System
Urinary System
Urinary System

Modifier(s)Crystals
Edema
Infiltrate, inflammatory cell
NecrosisHemorrhage
Angiectasis
Dilatation

Simple; Papillary; Nodular; With
atypia; Without atypia

Synonym

StatusModified after
publication
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published

Metaplasia, squamous cell

Published

Metaplasia, glandular

Published

Papilloma, urothelial cell

Modified after
publication
Modified after
publication
Modified after
publication

Papilloma, squamous cell
Carcinoma, urothelial

Organ Working GroupUrinary System
Urinary System
Urinary System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System

OrgansUreter; Urinary bladder;
UrethraUreter; Urinary bladder;
UrethraUrinary bladder; Urethra
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord

LesionCarcinoma, squamous cell

Modifier(s)Adenocarcinoma
Mesenchymal proliferative
lesionChromatolysis
Neuronal heterotopia
Necrosis, neuron
Neuronophagia
Vacuolation, neuron

Synonym

StatusPublished
Published

Solid; Polypoid

Published
Published
Modified after
publication
Modified after
publication
PublishedType II astrocytes

Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published

Astrocyte swelling/vacuolation

Published

Astrocyte swelling

Added after
publication
Published

Atrophy, axon
Degeneration, axon
Dystrophy, axon

Astrocytosis
Gliosis, not otherwise specified(NOS)

PublishedOrgan Working Group
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System

OrgansBrain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord

LesionMicrogliosis

Modifier(s)Synonym

StatusPublished

Satellitosis

Published

Demyelination

Published

Intramyelinic edema

Published

Vacuolation

Published

Infarct

Published

Thrombus

Published

Cholesterol clefts

Published

Hemorrhage

Published

Hydrocephalus
Inflammation

Published
Published

Infiltrate, inflammatory cell

Published

Pigment, lipofuscin

Modified after
publication
Published

Mineralization
Cyst, squamous
Syringomyelia/hydromyelia

Modified after
publication
PublishedOrgan Working Group
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System

Nervous System

OrgansBrain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord

LesionSyringomyelia

Modifier(s)Medulloblastoma

StatusAdded after
publication
Added after
publication
Published

Neuromyoblastoma, malignant

Published

Hydromyelia

Astrocytoma, malignant

Low grade; High grade.
Protoplasmic; Fibrillary;
Gemistocytic; Pilocytic (pilloid)
Low grade; High grade

Synonym

Modified after
publication

Nervous System
Nervous System
Nervous System

Brain; Cerebrum; Cerebellum; Glioma, mixed, malignant
Spinal cord
Brain; Cerebrum; Cerebellum; Oligodendroglioma, malignant
Spinal cord
General proliferative terms
Schwannoma, benign
General proliferative terms
Schwannoma, malignant
Cerebral meninx; Spinal meninx Aggregate, granular cell

Nervous System

Cerebral meninx; Spinal meninx Tumor, granular cell, benign

Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Published

Nervous System

Cerebral meninx; Spinal meninx Tumor, granular cell, malignant

Published

Nervous System

Cerebral meninx; Spinal meninx Meningioangiomatosis

Published

Nervous System

Cerebral meninx; Spinal meninx Meningioma, benign

Nervous System

Cerebral meninx; Spinal meninx Meningioma, malignant

Nervous System

Brain; Cerebrum; Cerebellum;
Spinal cord

Nervous System

Ependymoma, benign

Low grade; High grade

Fibroblastic type;
Meningothelial type; Mixed
type
Fibrous type; Spindloid type;
Undifferentiated type

Published

Published
PublishedOrgan Working Group
Nervous System

LesionEpendymoma, malignant

Mammary Gland and other
Mammary Gland and other

OrgansBrain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum
Brain; Cerebrum; Cerebellum
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Mammary gland
Mammary gland

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Mammary gland
Mammary gland
Mammary gland
Mammary gland

Necrosis
Basophilia
Infiltrate
Inflammation

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Mammary gland
Mammary gland
Mammary gland
Mammary gland
Mammary gland
Mammary gland

FibrosisCongestion
Edema
Hemorrhage
Angiectasis
Thrombus

Mammary Gland and other
Mammary Gland and other

Mammary gland
Mammary gland

Corpora amylacea
Amyloid

Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System

Modifier(s)Synonym

StatusPublished

Papilloma, choroid plexus
Carcinoma, choroid plexus
Hamartoma, lipomatous

Published
Published
Published

Reticulosis, malignant

Published

Dark neuron artifact

Published

Myelin bubbles

Published

Vacuolation, white matter

Modified after
publication
Published
Modified after
publication
Published
Published
Published
Published

Degeneration
Single cell necrosis

Acute; Chronic; Chronic active;
Granulomatous

Published
Published
Published
Published
Published
Modified after
publication
Published
PublishedOrgan Working Group
Mammary Gland and other

Organs
Mammary gland

LesionDilatation

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Mammary gland
Mammary gland
Mammary gland
Mammary gland

Mammary Gland and other

Mammary gland

Pigment
Mineralization
Atrophy
Hypertrophy/hyperplasia,
alveolar and/or ductal cell
Hyperplasia, lobuloalveolar

Mammary Gland and other

Mammary gland

Adenoma

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Mammary gland
Mammary gland
Mammary gland
Mammary gland
Mammary gland

Fibroadenoma
Adenomyoepithelioma
Tumor, mixed, benign
Carcinoma, adenosquamous
Adenocarcinoma

Mammary Gland and other

Mammary gland

Mammary Gland and other

Mammary gland

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Mammary gland
Zymbal's gland
Zymbal's gland

Adenocarcinoma arising infibroadenoma
Sarcoma arising infibroadenoma
Carcinosarcoma
Degeneration
Single cell necrosis

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Zymbal's gland
Zymbal's gland
Zymbal's gland

Necrosis
Basophilia
Infiltrate

Modifier(s)Diffuse; Focal; Focal with atypia;
Focal with fibrous tissue
proliferation
Cystic; Papillary;
Alveolar/tubular
Adenomatous; Fibromatous
Adenolipoma type
Alveolar/tubular; Comedo;
Cribriform; Cystic;
Medullary/solid; Papillary;
Scirrhous; Spindle cell;
UndifferentiatedSynonym

StatusModified after
publication
Published
Published
Published
Modified after
publication
Published

Published
Published
Published
Published
Published
Published

Published
Published
Published
Published
Modified after
publication
Published
Published
PublishedOrgan Working Group
Mammary Gland and other

Organs
Zymbal's gland

LesionDilatation

Mammary Gland and other

Zymbal's gland

Atrophy, acinar cell

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Zymbal's gland
Zymbal's gland
Zymbal's gland
Zymbal's gland

Hyperplasia
Adenoma, sebaceous cell
Papilloma, squamous cell
Carcinoma, sebaceous cell

Mammary Gland and other

Zymbal's gland

Carcinoma, squamous cell

Mammary Gland and other
Mammary Gland and other

Clitoral gland; Preputial gland
Clitoral gland; Preputial gland

Degeneration
Single cell necrosis

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Clitoral gland; Preputial gland
Clitoral gland; Preputial gland
Clitoral gland; Preputial gland
Clitoral gland; Preputial gland

Necrosis
Basophilia
Infiltrate
Inflammation

Mammary Gland and other

Clitoral gland; Preputial gland

Dilatation

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Clitoral gland; Preputial gland
Clitoral gland; Preputial gland
Clitoral gland; Preputial gland

Atrophy
Hyperplasia
Hyperplasia, squamous cell

Mammary Gland and other
Mammary Gland and other
Mammary Gland and other

Clitoral gland; Preputial gland
Clitoral gland; Preputial gland
Clitoral gland; Preputial gland

Adenoma
Papilloma, squamous cell
Adenocarcinoma

Mammary Gland and other
Mammary Gland and other

Clitoral gland; Preputial gland
Clitoral gland; Preputial gland

Tumor, basal cell, malignant
Carcinoma, squamous cell

Modifier(s)Ductular

Sebaceous cell; Squamous cell

Acute; Chronic; Chronic active;
Granulomatous
Ductular

Acinar; Ductular

Solid; Cystic; Papillary;
Papillary/cystic; Mixed cell
Keratinizing; Non-keratinizing

Synonym

StatusModified after
publication
Modified after
publication
Published
Published
Published
Modified after
publication
Added after
publication
Published
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
Published
Added after
publication
Published
Published
Published
Published
Added after
publication

Organ Working Group
Male Reproductive

OrgansTestisLesionAplasia

Male Reproductive
Male Reproductive
Male Reproductive

TestisTestisTestisHypoplasia
Cryptorchidism
Degeneration/atrophy, tubule

Male Reproductive

TestisDegeneration, tubule

Male Reproductive

TestisAtrophy, tubule

Male Reproductive

TestisNecrosis, tubule

Male Reproductive
Male Reproductive

TestisTestisNecrosis, testis
Vacuolation, tubule

Male Reproductive

TestisMultinucleated giant cells

Male Reproductive

TestisDilatation, tubule

Male Reproductive

TestisDilatation, rete testis

Male Reproductive
Male Reproductive

TestisTestisExfoliation, germ cell
Sperm stasis

Male Reproductive
Male Reproductive

TestisTestisSpermatocele
Degeneration, germ cell

Modifier(s)Spermatogonia; Spermatocytes;
Round spermatids; Elongating
spermatids

Synonym

StatusModified after
publication
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Published
PublishedOrgan Working Group
Male Reproductive

OrgansTestisLesionDepletion, germ cell

Male Reproductive

TestisSpermatid retention

Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive

TestisTestisTestisTestisTestisTestisTestisTestisTestisTestisResidual bodies, atypicalVacuolation, Leydig cell
Atrophy, Leydig cell
Necrosis, Leydig cell
Amyloid
Fibrosis
Mineralization
Pigment
Vacuolation, macrophage
Inflammation

Male Reproductive
Male Reproductive

TestisTestisMale Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive

TestisTestisTestisTestisTestisTestisTestisTestisTestisTestisTestisSperm granuloma
Necrosis/inflammation,
vascular/perivascular
Edema
Angiectasis
Hyperplasia, Leydig cell
Hyperplasia, rete testis
Hyperplasia, mesothelium
Adenoma, Leydig cell
Carcinoma, Leydig cell
Adenoma, rete testis
Carcinoma, rete testis
Mesothelioma, malignant
Tumor, mixed Sertoli-Leydig
cell, benign

Modifier(s)Synonym
Spermatogonia; Spermatocytes;
Round spermatids; Elongating
spermatids

Neutrophilic; Lymphocytic;
Mixed cell; Granulomatous

StatusPublished

Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published

Retiform (in rat)

Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive

OrgansTestisTestisTestisTestisTestisTestisTestisTestisLesionTumor, Sertoli cell, benign
Tumor, Sertoli cell, malignant
Tumor, granulosa cell, benign
Seminoma, benign
Seminoma, malignant
Carcinoma, embryonal
Choriocarcinoma
Carcinoma, yolk sac

Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive

TestisTestisEfferent ducts; Epididymis
Efferent ducts; Epididymis
Efferent ducts; Epididymis
Efferent ducts; Epididymis

Teratoma, benign
Teratoma, malignant
Aplasia
Hypoplasia
Spermatocele
Degeneration, epithelium

Male Reproductive

Efferent ducts; Epididymis

Atrophy, duct

Male Reproductive

Efferent ducts; Epididymis

Dilatation, duct

Male Reproductive
Male Reproductive

Efferent ducts; Epididymis
Efferent ducts; Epididymis

Cribriform change
Vacuolation, epithelium

Male Reproductive

Efferent ducts; Epididymis

Single cell necrosis

Male Reproductive
Male Reproductive

Efferent ducts; Epididymis
Efferent ducts; Epididymis

Metaplasia, squamous cell
Cell debris, lumen

Male Reproductive

Epididymis

Sperm, decreased, lumen

Male Reproductive
Male Reproductive

Efferent ducts; Epididymis
Efferent ducts; Epididymis

Sperm stasis
Amyloid

Modifier(s)CysticMacrovesicular; Microvesicular;
Basophilic

Caput; Cauda

Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Published
PublishedOrgan Working Group
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive

OrgansEpididymis
Epididymis
Efferent ducts; Epididymis
Efferent ducts; Epididymis

LesionKaryomegaly
Adenosis
Edema
Infiltrate, inflammatory cell

Male Reproductive

Efferent ducts; Epididymis

Inflammation

Male Reproductive
Male Reproductive

Efferent ducts; Epididymis
Efferent ducts; Epididymis

Published
Published

Male Reproductive
Male Reproductive
Male Reproductive

Epididymis
Epididymis
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland

Sperm granuloma
Necrosis/inflammation,
vascular/perivascular
Adenoma, Leydig cell
Histiocytic sarcoma
Aplasia

Hypoplasia

Published

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Modifier(s)Lymphocytic; Neutrophilic;
Plasmacytic; Mixed
inflammatory cell
Neutrophilic; Lymphocytic;
Lymphoplasmacytic; Mixed
inflammatory cell. Other
modifiers include purulent or
granulomatous

Synonym

StatusPublished
Published
Published
Published

Published

Published
Published
Published

Dilatation, acinar/vesicle

CysticModified after
publication

Atrophy

Acinar; Vesicle; Cystic

Published

Vacuolation, epithelium

Macrovesicular; Microvesicular

Modified after
publication

Organ Working Group
Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Male Reproductive

Organs
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland

LesionSingle cell necrosis

Modifier(s)Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland
Prostate; Seminal vesicle;
Coagulating gland;
Bulbourethral gland; Urethral
glandsFibrosis, stroma

Modified after
publication

Inflammation,
vascular/perivascular

Published

Angiectasis

Published

Necrosis

Metaplasia

Synonym

StatusModified after
publication
Published

Mucinous; Squamous cell;
Transitional cell

Published

Amyloid

Published

Corpora amylacea

Modified after
publication

Infiltrate, inflammatory cell

Inflammation

Lymphocytic; Neutrophilic;
Plasmacytic; Mixed
inflammatory cell
Neutrophilic; Lymphocytic;
Lymphoplasmacytic; Mixed cell.
Other modifiers include
purulent, or granulomatous

Published

PublishedOrgan Working Group
Male Reproductive
Male Reproductive
Male Reproductive

Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Male Reproductive
Soft Tissue

Organs
Prostate; Seminal vesicle;
Coagulating gland
Prostate; Seminal vesicle;
Coagulating gland
Prostate; Seminal vesicle;
Coagulating gland; Ampullary
gland
Prostate; Seminal vesicle
Prostate; Seminal vesicle;
Coagulating gland
Prostate; Coagulating gland
Seminal vesicle
Prostate; Seminal vesicle;
Coagulating gland
Prostate; Coagulating gland
Prostate
Prostate
Prostate; Seminal vesicle;
Coagulating gland
Prostate; Seminal vesicle;
Coagulating gland
Soft tissue

LesionHyperplasia, reactive

Modifier(s)Hyperplasia, diffuse

Synonym

StatusPublished
Modified after
publication
Published

Hyperplasia, atypicalMesenchymal proliferative
lesionAdenomaPublished

Papilloma, squamous cell
Tumor, epithelial-stromal,
benignAdenocarcinoma

Published
Published

Carcinoma, squamous cell
Carcinosarcoma
Tumor, neuroendocrine cell,malignantTumor, granular cell, benign

Published

Published
Adenosquamous

Tumor, granular cell, malignant
Infiltrate, inflammatory cell

Published
Published
Modified after
publication
Published
Published

Mononuclear cell; Lymphocyte;
Neutrophil; Eosinophil; Plasma
cell; Polymorphonuclear cell;
Mixed cell

PublishedOrgan Working Group
Soft Tissue

OrgansSoft tissue

LesionInflammation

Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue

Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Adipose tissue

Fibrosis
Fibroplasia
Necrosis
Mineralization
Metaplasia
Amyloid
Infiltrate, inflammatory cell

Soft Tissue

Adipose tissue

Inflammation

Soft Tissue

Adipose tissue

Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue

Adipose tissue
Adipose tissue
Adipose tissue
Adipose tissue

Inflammation,
lipogranulomatous
Necrosis
Atrophy
Hyperplasia, adipose tissue
Microvesicular change

Soft Tissue

Adipose tissue

Macrovesicular change

Soft Tissue

Soft tissue

Hyperplasia, smooth muscle

Modifier(s)Neutrophil (purulent);
Lymphocyte (non-purulent);
Eosinophil; Plasma cell;
Mononuclear cell; Mixed cell;
Granulomatous

Osseous; Cartilaginous type
Mononuclear cell; Lymphocyte;
Neutrophil; Eosinophil; Plasma
cell; Polymorphonuclear cell;
Mixed cell
Neutrophil (purulent);
Lymphocyte (non-purulent);
Eosinophil; Plasma cell;
Mononuclear cell; Mixed cell;
Granulomatous

Synonym

StatusPublished

Published
Published
Published
Published
Published
Published
Published

Published

Published

Serous; Mucoid

Published
Published
Published
Added after
publication
Added after
publication
PublishedOrgan Working Group
Soft Tissue

OrgansSkeletal muscle

LesionInfiltrate, inflammatory cell

Soft Tissue
Soft Tissue

Skeletal muscle
Skeletal muscle

Necrosis
Inflammation

Soft Tissue
Soft Tissue
Soft Tissue

Skeletal muscle
Skeletal muscle
Skeletal muscle

Hypertrophy
AtrophyDegeneration

Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue
Soft Tissue

Skeletal muscle
Skeletal muscle
Mesothelium
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue
Soft tissue

Soft Tissue

Mesothelium

Vacuolation
Mineralization
Hyperplasia
Fibroma
Fibrosarcoma
Fibrosarcoma, pleomorphic
LipomaHibernoma
Liposarcoma
Rhabdomyosarcoma
Leiomyoma
Leiomyosarcoma
Mesenchymoma, malignant
Sarcoma, NOS (Not otherwise
specified)
Mesothelioma, malignant

Modifier(s)Synonym
Mononuclear cell; Lymphocyte;
Neutrophil; Eosinophil; Plasma
cell; Polymorphonuclear cell;
Mixed cell

Neutrophil (purulent);
Lymphocyte (non-purulent);
Eosinophil; Plasma cell;
Mononuclear cell; Mixed cell;
Granulomatous

Angiomatous type

Epithelioid type; Sarcomatoid
type; Biphasic type

StatusPublished

Published
Published

Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Soft Tissue

OrgansSoft tissue

LesionTumor, granular cell, benign

Integument

Skin; Epidermis

Atrophy, epidermis

Integument
Integument

Skin; Epidermis
Skin; Epidermis

Erosion/ulcer
Necrosis, epidermis

Integument

Skin; Epidermis

Edema, epidermis, intracellular

Integument

Skin; Epidermis

Edema, epidermis, intercellular

Integument
Integument

Skin; Epidermis
Skin; Epidermis

Integument

Skin; Epidermis

VesicleInfiltrate, inflammatory cell,
epidermis
PustuleIntegument

Skin; Epidermis

Hyperkeratosis, epidermis

Integument

Skin; Cutaneous adnexa

Atrophy, adnexa

Integument

Skin; Cutaneous adnexa

Adnexal dysplasia

Integument

Skin; Cutaneous adnexa

Inflammation, adnexa

Integument

Skin; Cutaneous adnexa

Necrosis, adnexa

Integument

Skin; Cutaneous adnexa

Hyperkeratosis, adnexa

Integument

Skin; Dermis and subcutis

Atrophy, dermis

Integument

Skin; Dermis and subcutis

Edema, dermis

Modifier(s)Full thickness type; Single cell
type

Lymphocytic; Mononuclear;
Neutrophilic; Eosinophilic
Lymphocytic; Mononuclear;
Neutrophilic; Eosinophilic
Orthokeratotic; Parakeratotic;
Crust

Lymphocytic; Neutrophilic;
Eosinophilic; Granulomatous
Single cell type; Diffuse type

Synonym

StatusAdded after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication

Organ Working Group
Integument
Integument

Organs
Skin; Dermis and subcutis
Skin; Epidermis

LesionElastosis
Hyperplasia, epidermis

Modifier(s)Integument
Integument

Skin; Epidermis
Skin; Cutaneous adnexa

Cyst, squamous
Hyperplasia, adnexa

Integument
Integument

Skin; Dermis and subcutis
Skin; Epidermis

Hyperplasia, melanocyte
Papilloma, squamous cell

Integument

Skin; Epidermis

Carcinoma, squamous cell

Well differentiated type;
Moderately differentiated type;
Poorly differentiated type

Published

Integument

Skin; Cutaneous adnexa

Tumor, basal cell, benign

Modified after
publication

Integument

Skin; Cutaneous adnexa

Carcinoma, basal cell

Basosquamous type;
Trichoblastoma type; Granular
type
Basosquamous type; Solid type

Integument
Integument
Integument
Integument

Skin; Cutaneous adnexa
Skin; Cutaneous adnexa
Skin; Cutaneous adnexa
Skin; Cutaneous adnexa

Adenoma, sebaceous cell
Carcinoma, sebaceous cell
Keratoacanthoma
Tumor, hair follicle, benign

Integument
Integument
Integument
Female Reproductive
Female Reproductive
Female Reproductive

Skin; Cutaneous adnexa
Skin; Dermis and subcutis
Skin; Dermis and subcutis
Ovary
Ovary
Ovary

Carcinoma, eccrine gland
Melanoma, benign
Melanoma, malignant
AmyloidAngiectasis
Cyst, bursal

With cellular atypia

Hair follicle; Sebaceous gland

Exophytic; Endophytic; With
cellular atypia; Non-keratinizing

Trichofolliculoma type;
Trichoepithelioma type;
Tricholemmoma type;
Pilomatricoma typeAmelanotic type

Synonym

StatusPublished
Modified after
publication
Published
Modified after
publication
Published
Published

Published
Published
Published
Published
Published

Published
Published
Published
Published
Published
PublishedOrgan Working Group
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

LesionCyst, epithelial
Cyst, follicular
Cyst, luteal
Cyst, rete ovarii
Cyst, paraovarian
Cyst, NOS

Modifier(s)Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Organs
Ovary
Ovary
Ovary
Ovary
Ovary
Ovary; Uterus; Uterine cervix;
Vagina
Ovary
Ovary
Ovary
Ovary
Ovary
Ovary

Follicle, luteinizedVacuolation, theca cell
Vacuolation, granulosa cell
Vacuolation, interstitial cell
Vacuolation, corpora lutea
Mineralization

CysticIncreased; Decreased
Increased; Decreased
Increased; Decreased

Female Reproductive

Ovary

Infiltrate, inflammatory cellFemale Reproductive

Ovary

Inflammation, ovary

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Ovary
Ovary
Ovary
Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Age-related atrophy
Atrophy
Atrophy, corpora lutea
Corpora lutea, increased
numberDecreased number/absent
corpora lutea
Decreased number/absent
follicles

Female Reproductive

Ovary

Degeneration, corpora lutea

Oocyte; Corpus luteum;
Interstitial cell
Eosinophilic; Histiocytic;
Neutrophilic; Lymphocytic;
Mononuclear; Mixed
Neutrophilic; Lymphocytic;
Mononuclear; Mixed. Other
modifiers include suppurative,
granulomatous

Old; New; Recent
Primordial; Primary; Secondary;
Vesicular; Tertiary; Atretic

Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published

Published

Published
Published
Published
Modified after
publication
Published
Published

PublishedOrgan Working Group
Female Reproductive

Organs
Ovary

LesionAtretic follicles, increased
numberFemale Reproductive
Female Reproductive

Ovary
Ovary

Degeneration, oocyte
Pigment

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Ovary
Ovary
Ovary
Ovary
Ovary

Edema
Ovotestis
Follicle, polyovular
Ectopic tissue
Immature

Female Reproductive
Female Reproductive

Ovary
Ovary

Hypertrophy, interstitial cell
Hypertrophy, corpora lutea

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Ovary
Ovary
Ovary
Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Hyperplasia, interstitial cell
Hyperplasia, tubulostromal
Hyperplasia, cystic/papillary
Hyperplasia, sex cord stromal,
granulosa cell
Hyperplasia, sex cord stromal,
theca cell
Hyperplasia, sex cord stromal,
Sertoli cell
Hyperplasia, sex cord stromal,
luteinizedHyperplasia, sex cord stromal,
mixed

Modifier(s)Synonym
Primordial; Primary; Secondary;
Vesicular; Tertiary; Atretic

Hemosiderin; Lipofuscin;
Ceroid. Alternatively, if pigment
isn't definitively identified,colors can be used as modifiers

Diffuse; Focal

StatusPublished

Published
Published

Published
Published
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Added after
publication
Modified after
publication

Organ Working Group
Female Reproductive

Organs
Ovary

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Ovary
Ovary
Ovary
Ovary
Ovary
Ovary
Ovary; Uterus; Uterine cervix
Ovary; Uterus; Uterine cervix
Ovary; Uterus; Uterine cervix
Ovary
Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

Female Reproductive

Ovary

LesionHyperplasia, smooth muscle,
mesovarium
Hyperplasia, rete ovarii
Adenoma, rete ovarii
Cystadenoma
Cystadenocarcinoma
Adenoma, tubulostromal
Carcinoma, tubulostromal
Carcinoma, yolk sac
Choriocarcinoma
Carcinoma, embryonal
Dysgerminoma
Leiomyoma, mesovarium
Tumor, sex cord stromal,
granulosa cell, benign
Tumor, sex cord stromal,
granulosa cell, malignant
Tumor, sex cord stromal, Sertoli
cell, benign
Tumor, sex cord stromal, Sertoli
cell, malignant
Tumor, sex cord stromal, mixed,
benignTumor, sex cord stromal, mixed,
malignantTumor, sex cord stromal, thecacell, benign
Tumor, sex cord stromal, thecacell, malignant
Tumor, sex cord stromal,
luteinized, benign

Modifier(s)Synonym

StatusModified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication

Organ Working Group
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

OrgansOvary; Uterus
Ovary; Uterus
UterusUterus; Uterine cervix; Vagina

LesionTeratoma, benign
Teratoma, malignant
Aplasia, segmental
Atrophy

Female Reproductive
Female Reproductive

UterusUterusHypoplasia
Hypertrophy, epithelium

Female Reproductive

UterusHypertrophy, myometrium

Female Reproductive

UterusDilatation, lumen

Female Reproductive

UterusDilatation, glandular, cystic

Female Reproductive
Female Reproductive
Female Reproductive

UterusAdenomyosis
UterusAngiectasis
Oviduct; Uterus; Uterine cervix; Infiltrate, inflammatory cell
VaginaFemale Reproductive

UterusInflammation, endometrium

Female Reproductive

UterusInflammation, myometrium

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

UterusUterusUterusUterusAbscess(es)PyometraGranuloma
Amyloid

Modifier(s)Epithelial; Endometrial;
Myometrial; Stromal
Endometrial; Epithelial

CysticEosinophilic; Histiocytic;
Neutrophilic; Lymphocytic;
Mononuclear; Mixed
Neutrophilic; Lymphocytic;
Mononuclear; Mixed. Other
modifiers include suppurative,
granulomatous
Neutrophilic; Lymphocytic;
Mononuclear; Mixed. Other
modifiers include suppurative,
granulomatous

Synonym

StatusPublished
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Published

Published

Published

Published
Published
Published
PublishedOrgan Working Group
Female Reproductive

OrgansUterusLesionPigment

Female Reproductive

UterusApoptosis

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

UterusUterusUterusUterusUterusUterusUterusNecrosis
Fibrosis
Decidual reaction
Decidualization, focal
Mesonephric duct remnants
Metaplasia, squamous cell
Vacuolation, epithelium

Female Reproductive

Oviduct

Inflammation, oviductFemale Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Oviduct
Oviduct
UterusUterusUterusFemale Reproductive

UterusFemale Reproductive
Female Reproductive

UterusUterus

Salpingitis isthmica nodosa
Atrophy
Hyperplasia, glandular, cystic
Hyperplasia, glandular, focal
Hyperplasia, endometrium,
diffuseHyperplasia, endometrial
stromalHyperplasia, angiomatous
Hyperplasia, myometrium

Female Reproductive

Oviduct

Hyperplasia, epithelium

Modifier(s)Synonym
Hemosiderin; Ceroid;
Lipofuscin/ceroid. Alternatively,
if pigment isn't definitively
identified, colors can be used as
modifiers
Endometrial; Luminal;
Epithelial; Glandular; Stromal
Endometrial; Myometrial
Myometrial; Stromal

Non-keratinizing; Keratinizing

Neutrophilic; Lymphocytic;
Mononuclear; Mixed. Other
modifiers include suppurative,
granulomatous

Cystic; Endometrial
AtypicalStatusPublished

Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published

Published
Published
Published
Published
Modified after
publication
Published
Published
Modified after
publication
Modified after
publication

Organ Working Group
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

OrgansUterus; Uterine cervix
Uterus; Uterine cervix
UterusUterusUterus; Uterine cervix

LesionPolyp, glandular
Polyp, endometrial stromal
Sarcoma, endometrial stromal
Histiocytic sarcoma
Adenoma, endometrium

Modifier(s)Female Reproductive

Uterus; Uterine cervix

Adenocarcinoma, endometrium

Female Reproductive
Female Reproductive
Female Reproductive

Uterus; Uterine cervix
Uterus; Uterine cervix; Vagina
Uterus; Uterine cervix

Carcinoma, adenosquamous
Carcinoma, squamous cell
Keratinizing; Non-keratinizing
Tumor, mixed Müllerian, benign Homologous; Heterologous

Female Reproductive

Uterus; Uterine cervix

Female Reproductive

Uterus; Uterine cervix; Vagina

Tumor, mixed Müllerian,malignantLeiomyoma

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Uterus; Uterine cervix; Vagina
Uterus; Uterine cervix; Vagina
Uterus; Uterine cervix; Vagina
Uterine cervix; Vagina
Uterine cervix; Vagina

Leiomyosarcoma
Schwannoma, benign
Schwannoma, malignant
Aggregate, granular cell
Atrophy, epithelium

Female Reproductive

Uterine cervix; Vagina

Degeneration, epithelium

Female Reproductive
Female Reproductive
Female Reproductive

Uterine cervix; Vagina
VaginaUterine cervix; Vagina

Erosion/ulcer
Imperforate vagina
Keratinization, increased

Female Reproductive

Uterine cervix; Vagina

Mucification, increased

Synonym

StatusPublished
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Published

Homologous; Heterologous

Published

Myometrium; Mesovarium;
UterusUterusPublished
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Modified after
publication

Organ Working Group
Female Reproductive

OrgansUterus; Uterine cervix; Vagina

LesionInflammation

Female Reproductive

Uterine cervix; Vagina

Necrosis, epithelium

Female Reproductive
Female Reproductive
Female Reproductive

Uterus; Uterine cervix; Vagina
VaginaUterine cervix; Vagina

Prolapse
Prostatic rudiment
Vacuolation, epithelium

Female Reproductive
Female Reproductive

Uterine cervix; Vagina
Uterine cervix; Vagina

AdenosisHyperplasia, epithelium

Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive
Female Reproductive

Uterus; Uterine cervix; Vagina
Uterine cervix
Uterine cervix
Uterine cervix; Vagina
Uterus; Uterine cervix; Vagina
VaginaUterine cervix
Uterus; Uterine cervix; Vagina
Uterus; Uterine cervix; Vagina

Hyperplasia, granular cell
Hyperplasia, stroma
Hypertrophy, stroma
Keratoacanthoma
Keratinizing; Non-keratinizing
Papilloma, squamous cell
Keratinizing; Non-keratinizing
Polyp, vaginal
Sarcoma, stromal
Tumor, granular cell, benign
Tumor, granular cell, malignant

Digestive

Oral cavity, NOS

Ectopic tissue, sebaceous gland

Digestive
Digestive
Digestive
Digestive

Oral cavity, NOS
Esophagus
Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus

Cleft palate
Dilatation, esophagus
Diverticulum, esophagus
Malformation

Modified after
publication
Published
Published
Published
Published

Cyst

Published

Digestive

Modifier(s)Neutrophilic; Lymphocytic;
Mononuclear; Mixed. Other
modifiers include suppurative,
granulomatous

Basal cell; Squamous cell

Synonym

StatusPublished

Modified after
publication
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive

Digestive
Digestive
Digestive
Digestive

OrgansTongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus

LesionModifier(s)Atrophy, squamous epithelium

Synonym

StatusPublished

Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus

Inflammation, mononuclear cell

Published

Inflammation, mixed cell

Published

Inflammation, foreign body

Published

Inflammation, vessel

Published

Erosion/ulcer

Published

Apoptosis, squamous
epithelium
Necrosis, squamous epithelium Single cell

Published

Apoptosis/single cell necrosis
Degeneration/necrosis, muscle

Modified after
publication
Published

Amyloid

Published

Mineralization

Published

Pigment

Published

Published

Hyperkeratosis

Orthokeratotic; Parakeratotic

Published

Infiltrate

Type of inflammatory cell that
represents the predominant cell
type in the infiltrate

PublishedOrgan Working Group
Digestive

LesionEdema

Digestive

OrgansTongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Tongue; Pharynx; Oral cavity,
NOS; Esophagus
Nonglandular stomach
Nonglandular stomach;
Glandular stomach
Nonglandular stomach

Atrophy, squamous epithelium

Published

Digestive

Nonglandular stomach

Published

Digestive

Nonglandular stomach

Digestive

Nonglandular stomach

Vacuolation, squamous
epithelium
Apoptosis, squamous
epithelium
Necrosis, squamous epithelium Single cell

Digestive

Nonglandular stomach

Apoptosis/single cell necrosis

Digestive
Digestive
Digestive

Nonglandular stomach
Nonglandular stomach
Glandular stomach

Erosion/ulcer
Hyperkeratosis
Dilatation, gland

Digestive

Glandular stomach

Cyst, glandular

Modified after
publication
Published
Published
Modified after
publication
Published

Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive

Modifier(s)Hemorrhage
Hyperplasia, squamous cell

Synonym

StatusPublished
Published

AtypicalPublished

Hyperplasia, basal cell

Published

Papilloma, squamous cell

Published

Carcinoma, squamous cell

Published

Tumor, granular cell, benign

Published

Cyst, squamous
Ectopic tissue

Published
Published

Hepatocytes; Pancreas

Orthokeratotic; Parakeratotic

Published
PublishedOrgan Working Group
Digestive

OrgansGlandular stomach

LesionAtrophy

Digestive

Glandular stomach

Vacuolation, epithelium

Digestive

Glandular stomach

Secretion, decreased

Digestive
Digestive
Digestive
Digestive

Glandular stomach
Glandular stomach
Glandular stomach
Glandular stomach

Eosinophilic globules
Apoptosis
Necrosis, mucosa
Apoptosis/single cell necrosis

Digestive
Digestive
Digestive
Digestive
Digestive

Glandular stomach
Glandular stomach
Glandular stomach
Glandular stomach
Nonglandular stomach;
Glandular stomach

Erosion/ulcer
Hypertrophy, mucous cell
Amyloid
Mineralization
Infiltrate

Digestive

Nonglandular stomach;
Glandular stomach

Inflammation

Digestive

Nonglandular stomach;
Glandular stomach
Nonglandular stomach;
Glandular stomach
Nonglandular stomach
Nonglandular stomach
Nonglandular stomach
Nonglandular stomach
Nonglandular stomach

Helicobacter

Published

Yeast

Published

Digestive
Digestive
Digestive
Digestive
Digestive
Digestive

Hyperplasia, squamous cell
Hyperplasia, basal cell
Papilloma, squamous cell
Carcinoma, squamous cell
Tumor, basal cell, benign

Modifier(s)Mucosa or specific cell type(e.g., chief cell, parietal or
mucous cell)
Mucosa or specific cell type(e.g., chief cell, parietal or
mucous cell)

Single cell

Type of inflammatory cell that
represents the predominant cell
type in the infiltrate
Type of inflammatory cell that
represents the predominant cell
type in the infiltrate

Reactive

Synonym

StatusPublished

Published

Modified after
publication
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published

Published

Published
Published
Published
Published
PublishedOrgan Working Group
Digestive
Digestive
Digestive

OrgansNonglandular stomach
Glandular stomach
Glandular stomach

LesionTumor, basal cell, malignant
Diverticulum
Hyperplasia, mucosa, focal

Digestive

Glandular stomach

Hyperplasia, mucosa, diffuse

Digestive

Glandular stomach

Digestive
Digestive

Glandular stomach
Glandular stomach

Hyperplasia, neuroendocrine
cell
Adenoma
Adenocarcinoma

Digestive

Glandular stomach

Digestive

Glandular stomach

Digestive
Digestive
Digestive

Glandular stomach
Glandular stomach
Glandular stomach

Digestive

Glandular stomach

Digestive

Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Cyst, squamous
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS

Digestive

Modifier(s)Cystic; AtypicalAtypical

Polypoid; Papillary; Sessile
Tubular; Papillary; Cystic; Solid;
Scirrhous; Mucinous; Signet
ring; Undifferentiated; Mixed

Tumor, neuroendocrine cell,benignTumor, neuroendocrine cell,malignantLeiomyoma
Leiomyosarcoma
Gastrointestinal stromal tumor(GIST), benign
Gastrointestinal stromal tumor(GIST), malignant
Ectopic tissue
Pancreas

Synonym

StatusPublished
Published
Modified after
publication
Modified after
publication
Published
Published
Published

Published
Published
Published
Published
Published
Published
Published

PublishedOrgan Working Group
Digestive

Organs
Duodenum

LesionAtrophy, Brunner's glands

Modifier(s)Digestive

Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS
Cecum; Colon; Rectum; Large
intestine, NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum

Atrophy

Villous; Mucosal

StatusModified after
publication
Published

Hypertrophy

Villous; Mucosal

Published

Digestive

Digestive
Digestive
Digestive
Digestive

Digestive
Digestive

Digestive

Paneth cell, decreased

Synonym

Hypertrophy, Paneth cell

Modified after
publication
Published

Metaplasia, Paneth cell

Published

Vacuolation, mucosa

Degeneration/necrosis,
Brunner's glands
Lymphangiectasis

Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Syncytia, epithelium
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS

Foamy

Published

Published
Published

PublishedOrgan Working Group
Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Organs
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS

LesionApoptosis

Modifier(s)Necrosis, mucosa

Single cell

Synonym

StatusPublished

Published

Apoptosis/single cell necrosis

Modified after
publication

Erosion/ulcer

Published

Amyloid

Published

Mineralization

Published

Metaplasia, osseous

Published

Dilatation

PublishedOrgan Working Group
Digestive

Digestive
Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive
Digestive

Organs
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Rectum; Large intestine, NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum
Colon; Rectum; Large intestine,
NOS

LesionIntussusception

Prolapse
Infiltrate

Modifier(s)Type of inflammatory cell that
represents the predominant cell
type in the infiltrate

Synonym

StatusPublished

Published
Published

Inflammation

Type of inflammatory cell that
represents the predominant cell
type in the inflammation

Published

Parasite

Protozoa; Nematode

Published

Degeneration, neuron,
myenteric plexus

Modified after
publication

Diverticulum

Cystic; AtypicalPublished

Hyperplasia, mucosa

Avillous; Atypical; Goblet cell

Published

Hyperplasia, Brunner's glands
Metaplasia, squamous cell

Published
PublishedOrgan Working Group
Digestive

Digestive

Digestive
Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

OrgansLesionDuodenum; Jejunum; Ileum;
Adenoma
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Adenocarcinoma
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum
Carcinoma, Brunner's glands
Duodenum; Jejunum; Ileum;
Leiomyoma
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Leiomyosarcoma
Small intestine, NOS; Cecum;
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Gastrointestinal stromal tumor
Small intestine, NOS; Cecum;(GIST), benign
Colon; Rectum; Large intestine,
NOS
Duodenum; Jejunum; Ileum;
Gastrointestinal stromal tumor
Small intestine, NOS; Cecum;(GIST), malignant
Colon; Rectum; Large intestine,
NOS
Submandibular gland;
Ectopic tissue
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Vacuolation
Sublingual gland; Parotid gland;
Salivary gland, NOS

Modifier(s)Polypoid; Papillary; Sessile

Solid; Papillary; Cystic;
Scirrhous; Mucinous; Signet
ring; Mixed; UndifferentiatedSynonym

StatusPublished

Published

Published
Published

Published

Published

Published

Parotid gland; Submandibular
gland; Sublingual gland

Published

Foamy

PublishedOrgan Working Group
Digestive

Digestive

Digestive

Digestive

Digestive

Digestive
Digestive
Digestive

Digestive

Digestive

Digestive

OrgansLesionModifier(s)Submandibular gland;
Accumulation, adipocytes
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Apoptosis
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Necrosis
Single cell
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Apoptosis/single cell necrosis
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Secretion, decreased, acinar cell
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland
Secretion, decreased, granular
duct
Submandibular gland
Granules increased, granular
duct
Submandibular gland;
Atrophy
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Mineralization
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Pigment
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Amyloid
Sublingual gland; Parotid gland;
Salivary gland, NOS

Synonym

StatusPublished

Published

Published

Modified after
publication
Modified after
publication
Modified after
publication
Published
Published

Published

Published

PublishedOrgan Working Group
Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive
Digestive

Digestive

OrgansLesionSubmandibular gland;
Infiltrate
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Inflammation
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Edema
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Hemorrhage
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Calculus, duct
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Ectasia, duct
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Fibrosis
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Hypertrophy, acinar cell
Sublingual gland; Parotid gland;
Salivary gland, NOS
Parotid gland
Focus, hypertrophic, basophilic
Submandibular gland;
Metaplasia, acinar cell
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Metaplasia, squamous cell
Sublingual gland; Parotid gland;
Salivary gland, NOS

Modifier(s)Synonym
Type of inflammatory cell that
represents the predominant cell
type in the infiltrate
Type of inflammatory cell that
represents the predominant cell
type in the inflammation

StatusPublished

Published

Published

Published

Modified after
publication
Published

Published

Published

Published
Published

PublishedOrgan Working Group
Digestive

StatusPublished

Digestive
Digestive
Digestive
Digestive
Digestive

OrgansLesionModifier(s)Synonym
Submandibular gland;
Hyperplasia
Acinar; Ductal; Reactive;
Sublingual gland; Parotid gland;
Atypical
Salivary gland, NOS
Submandibular gland;
AdenomaAcinar; Tubular; Papillary; Solid;
Sublingual gland; Parotid gland;
Mixed acinar/tubular
Salivary gland, NOS
Submandibular gland;
Adenocarcinoma
Acinar; Tubular; Papillary; Solid;
Sublingual gland; Parotid gland;
Mixed acinar/tubular/solid
Salivary gland, NOS
Submandibular gland;
Carcinoma, squamous cell
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Tumor, mixed, benign
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Tumor, mixed, malignant
Sublingual gland; Parotid gland;
Salivary gland, NOS
Submandibular gland;
Myoepithelioma, malignant
Sublingual gland; Parotid gland;
Salivary gland, NOS
Pancreas (exocrine)
Ectopic tissue
Pancreas (exocrine)
Vacuolation, acinar cell
Foamy
Pancreas (exocrine)
Accumulation, adipocytes
Pancreas (exocrine)
Eosinophilic globules
Pancreas (exocrine)
Autophagic vacuoles, acinar cell

Digestive
Digestive
Digestive

Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)

Published
Published
Modified after
publication

Digestive

Digestive

Digestive

Digestive

Digestive

Digestive

Apoptosis
Necrosis
Apoptosis/single cell necrosis

Single cell

Published

Published

Published

Published

Published

Published

Published
Published
Published
Published
PublishedOrgan Working Group
Digestive

Organs
Pancreas (exocrine)

LesionModifier(s)Secretion, decreased, acinar cell

Digestive
Digestive
Digestive
Digestive
Digestive

Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)

Atrophy, acinar cell
Mineralization
Amyloid
Pigment
Infiltrate

Digestive

Pancreas (exocrine)

Inflammation

Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive

Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)

Inflammation, vessel
Edema
Hemorrhage
Hypertrophy, acinar cell
Halos, peri-insular, increased
Halos, peri-insular, decreased
Focus, basophilic
Metaplasia, hepatocyte

Digestive

Pancreas (exocrine)

Metaplasia, ductule

Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Digestive
Cardiovascular System

Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)
Pancreas (exocrine)Heart

Ectasia, duct
FibrosisHyperplasia, acinar cell
Hyperplasia, ductal cell
Adenoma, acinar cell
Adenoma, ductal cell
Adenocarcinoma, acinar cell
Adenocarcinoma, ductal cell
CardiomegalyType of inflammatory cell that
represents the predominant cell
type in the infiltrate
Type of inflammatory cell that
represents the predominant cell
type in the inflammation

Focal; Diffuse

Synonym

StatusModified after
publication
Published
Published
Published
Published
Published

Published

Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Cardiovascular System
Cardiovascular System
Cardiovascular System

Organs
Heart
Heart
Heart

Cardiovascular System

Heart

LesionHypertrophy, cardiomyocyte
Degeneration, cardiomyocyte
Degeneration/necrosis,
cardiomyocyte
Necrosis, cardiomyocyte

Cardiovascular System

Heart

Necrosis/infiltrate

Cardiovascular System

Heart

Infiltrate/fibrosis

Cardiovascular System

Heart

Cardiovascular System
Cardiovascular System
Cardiovascular System

Heart
Heart
Heart

Rodent progressive
cardiomyopathy
Vacuolation, cardiomyocyte
Apoptosis, cardiomyocyte
Infarct

Cardiovascular System
Cardiovascular System

Heart
Heart

Fibrosis, myocardium
Infiltrate, inflammatory cell

Cardiovascular System
Cardiovascular System
Cardiovascular System

Heart
Heart
Heart

Cardiovascular System

Heart

Cardiovascular System

Heart

Edema, myocardium
Thrombus, atrium
Mineralization, cardiomyocyte
or myocardium
Pigment, cardiomyocyte or
myocardium
Amyloid

Cardiovascular System

Heart valves

Cardiovascular System

Heart valves

Degeneration, myxomatous,
valve
Proliferation, stroma, valve

Cardiovascular System

Heart valves

Inflammation, valve

Modifier(s)Hyaline; Vacuolar; Fatty

Coagulative; Lytic; Contraction
band (Zenker's)Synonym

StatusPublished
Published
Published
Published
Modified after
publication
Modified after
publication
Added after
publication
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
Modified after
publication
PublishedOrgan Working Group
Cardiovascular System
Cardiovascular System

OrgansHeart valves
Blood vessels; Aorta

LesionAngiectasis, valve
Hypertrophy, endothelium

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System
Cardiovascular System

Blood vessels; Aorta
Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System
Cardiovascular System
Cardiovascular System
Cardiovascular System
Cardiovascular System

Blood vessels; Aorta
Blood vessels; Aorta
Blood vessels; Aorta
Blood vessels; Aorta
Blood vessels; Aorta

Hypertrophy, media or wall,arteryHemorrhage, media or wall,arteryDegeneration/necrosis, media
or wall, artery
Necrosis/inflammation, media
or wall, artery
Inflammation, media or wall,arteryVacuolation, media oradventitia, artery
Infiltrate, inflammatory cell,
perivascular
Fibrosis, perivascular
Intimal thickening, acellular,arteryMineralization, media or wall,arteryAneurysm, artery or aortic
Angiectasis
Thrombus
Embolus
Amyloid, media or wall, artery

Cardiovascular System
Cardiovascular System

Blood vessels; Aorta
Heart

Intramural plaque, artery
Hyperplasia, Schwann cell,subendocardium

Modifier(s)Dilated; Dissecting; Aortic

Synonym

StatusPublished
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
PublishedOrgan Working Group
Cardiovascular System

OrgansHeart

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System

Blood vessels; Aorta

Cardiovascular System
Cardiovascular System
Cardiovascular System
Cardiovascular System

Blood vessels; Aorta
Heart
Heart
Heart

Cardiovascular System
Cardiovascular System
Cardiovascular System
Cardiovascular System
Skeletal Tissues

Heart
Heart
Blood vessels; Aorta
Blood vessels; Aorta
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS

Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

LesionHyperplasia, mesothelium,
epicardium or pericardium
Proliferation, intimal, artery orveinHyperplasia,
hemangioendothelium
Hyperplasia, angiomatous
Schwannoma, endocardial
Schwannoma, intramural
Mesothelioma, epicardium or
pericardium
Mesothelioma, atriocaval
Paraganglioma
Hemangioma
Hemangiosarcoma
Fibro-osseous lesion (FOL)

Modifier(s)Epithelioid type; Sarcomatoid
type; Biphasic type

Capillary; Cavernous

Synonym

StatusModified after
publication
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published

Fibrous osteodystrophy (FOD)

Published

Bone, increased, trabeculae
and/or cortex
Osteoid, increased

Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication

Osteoblastic surface, increased
Osteoclasts, increased
Eroded surface, increased
Bone, decreased, trabeculae
and/or cortex

Organ Working Group
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

OrgansFemur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS
Femur; Sternum; Vertebrae;
Bone, NOS

LesionCyst, bone

Modifier(s)Synonym

StatusPublished

Necrosis

Published

Fracture

PublishedPhysis, increased thickness

Growth plate closed

Modified after
publication
Added after
publication
Modified after
publication
Published

Hyperplasia, chondrocyte

Published

Hyperplasia, osteoblast, focal

Published

OsteomaPublished

Osteoblastoma

Published

Osteofibroma

Published

Osteosarcoma

Published

Fibrosarcoma, osteogenic
Chondroma

Modified after
publication
Published

Chondrosarcoma

Published

Physeal dysplasia
Physis, decreased thickness

Organ Working Group
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

OrgansFemur; Sternum; Vertebrae;
Bone, NOS
Vertebrae; Bone, NOS
Joint
Joint
Joint

LesionOsteochondroma

Skeletal Tissues

Joint

Skeletal Tissues
Skeletal Tissues

Joint
Joint

Chordoma
Inflammation
Osteophyte
Degeneration,chondromucinous
Degenerative joint disease(DJD)
Hyperplasia, synovial cell
Sarcoma, synovial

Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

Tooth
Tooth
Tooth
Tooth
Tooth
Tooth
Tooth

Degeneration
Necrosis
Periodontal pocket
Dentin niches
Dentin, decreased
Dentin matrix alteration
Dental dysplasia

Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

Tooth
Tooth
Tooth

Fracture
Resorption
Denticle

Skeletal Tissues
Skeletal Tissues

Tooth
Tooth

Pulp concretion
Cyst

Skeletal Tissues
Skeletal Tissues
Skeletal Tissues
Skeletal Tissues

Tooth
Tooth
Tooth
Tooth

Thrombus
Odontoma
Ameloblastic odontoma
Ameloblastoma

Modifier(s)Synonym

StatusPublished
Published
Published
Published
Modified after
publication
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
PublishedOrgan Working Group
Skeletal Tissues

Organs
Tooth

LesionFibroma, odontogenic

Skeletal Tissues

Tooth

Fibroma, cementifying/ossifying

Skeletal Tissues
Skeletal Tissues

Tooth
Tooth

Tumor, odontogenic, benign
Tumor, odontogenic, malignant

Endocrine

Pituitary gland

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland

Aberrant craniopharyngeal
structures
Angiectasis
Aplasia/hypoplasia
Atrophy
Cyst
Fibrosis
Gliosis, pars nervosa
Hemorrhage
Hypertrophy, pars intermedia
Hypertrophy, pars distalis
Infiltrate, inflammatory cell
Inflammation
Metaplasia, osseous

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland

Persistent Rathke's pouch
Pigment
Pseudocyst
Thrombus
Vacuolation
Hyperplasia, pars distalis
Hyperplasia, pars intermedia
Adenoma, pars distalis
Adenoma, pars intermedia
Ganglioneuroma, benign

Modifier(s)Synonym

StatusModified after
publication
Modified after
publication
Published
Published
Published

Hemosiderin; Lipofuscin

Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Organs
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland
Pituitary gland

LesionModifier(s)Pituicytoma, benign
Pituicytoma, malignant
Carcinoma, pars distalis
Carcinoma, pars intermedia
Craniopharyngioma, benign
Craniopharyngioma, malignant

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Pineal gland
Pineal gland
Pineal gland
Pineal gland
Pineal gland
Pineal gland
Pineal gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland

Fibrosis
Infiltrate, inflammatory cell
Mineralization
Striated muscle fibers
Vacuolation
Pinealoma, benign
Pinealoma, malignant
Amyloid
Atrophy
Colloid alteration
Cystic follicle
Ectopic tissue, thymus
Ectopic tissue, thyroid
Hypertrophy, follicular cell
Dilatation, follicle, diffuse

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland
Thyroid gland

Infiltrate, inflammatory cell
Inflammation
Mineralization
Persistent thyroglossal duct
Pigment
Thyroid dysplasia
Cyst, ultimobranchial

Endocrine

Thyroid gland

Hyperplasia, follicular cell

Focal; Cystic; Diffuse

Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Modified after
publication
PublishedOrgan Working Group
Endocrine

OrgansThyroid gland

LesionAdenoma, follicular cell

Modifier(s)Synonym
Follicular; Cystic; Papillary; Solid

StatusPublished

Endocrine

Thyroid gland

Carcinoma, follicular cell

Published

Endocrine
Endocrine

Thyroid gland
Thyroid gland

Hyperplasia, C-cell
Adenoma, C-cell

Follicular; Papillary;
Pleomorphic; Solid
Focal; Diffuse; Complex type
Ganglioneuroma type; Complex
type

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Thyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland
Parathyroid gland

Carcinoma, C-cell
AmyloidAngiectasis
Atrophy
Cyst
Ectopic tissue, parathyroid
Ectopic tissue, thymus
FibrosisHypertrophy
Infiltrate, inflammatory cell
Inflammation
Multinucleated giant cells

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Parathyroid gland
Parathyroid gland
Parathyroid gland
Adrenal gland
Adrenal gland
Adrenal gland

Hyperplasia
Adenoma
Carcinoma
AmyloidAngiectasis
Atrophy, cortex

Endocrine

Adrenal gland

Cyst, cortex

Endocrine
Endocrine
Endocrine

Adrenal gland
Adrenal gland
Adrenal gland

Degeneration, cystic
Ectopic tissue, adrenocortical
Fibrosis

Diffuse; Focal

Focal; Diffuse

Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
PublishedOrgan Working Group
Endocrine
Endocrine
Endocrine

OrgansAdrenal gland
Adrenal gland
Adrenal gland

LesionExtramedullary hematopoiesis
Hemorrhage
Hypertrophy, cortex, diffuse

Endocrine

Adrenal gland

Hypertrophy, cortex, focal

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Adrenal gland
Adrenal gland
Adrenal gland
Adrenal gland
Adrenal gland

Infiltrate, inflammatory cell
Inflammation
Mineralization
Necrosis
Metaplasia, osseous

Endocrine
Endocrine
Endocrine

Adrenal gland
Adrenal gland
Adrenal gland

Endocrine

Adrenal gland

Endocrine

Adrenal gland

Endocrine

Adrenal gland

Endocrine
Endocrine

Adrenal gland
Adrenal gland

Pigment
Thrombus
Vacuolation, cortex, increased,
diffuseVacuolation, cortex, increased,
focal
Vacuolation, cortex, decreased,
diffuseVacuolation, cortex, decreased,
focal
Persistent X-zone
Hyperplasia, cortex, diffuse

Endocrine

Adrenal gland

Hyperplasia, cortex, focal

Endocrine

Adrenal gland

Adenoma, cortex

Endocrine

Adrenal gland

Carcinoma, cortex

Endocrine

Adrenal gland

Hyperplasia, subcapsular cell

Modifier(s)Type A; Type B; Mixed type

Synonym

StatusPublished
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
PublishedOrgan Working Group
Endocrine

OrgansAdrenal gland

LesionAdenoma, subcapsular cell

Modifier(s)Type A; Type B; Mixed type

Endocrine
Endocrine

Adrenal gland
Adrenal gland

Carcinoma, subcapsular cell
Hyperplasia, medulla, diffuse

Type A; Type B; Mixed type

Endocrine

Adrenal gland

Hyperplasia, medulla, focal

Endocrine
Endocrine

Adrenal gland
Adrenal gland

Pheochromocytoma, benign
Pheochromocytoma, malignant

Endocrine

Adrenal gland

Endocrine

Adrenal gland

Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine
Endocrine

Adrenal gland
Adrenal gland
Adrenal gland
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)

Pheochromocytoma, complex,
benignPheochromocytoma, complex,
malignantGanglioneuroma, benign
Neuroblastoma, malignant
Myelolipoma
Amyloid, islet
Angiectasis, islet
Apoptosis, islet cell
Atrophy, islet cell
Degranulation, islet cell
Fibrosis, islet
Hemorrhage, islet
Hypertrophy, islet cell
Infiltrate, inflammatory cell
Inflammation
Metaplasia, hepatocyte
Single cell necrosis

Endocrine
Endocrine

Pancreas (endocrine)
Pancreas (endocrine)

Pigment, islet
Vacuolation, islet cell

Synonym

StatusModified after
publication
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
PublishedOrgan Working Group
Endocrine

Organs
Pancreas (endocrine)

LesionHyperplasia, islet cell

Endocrine
Endocrine
Endocrine
Endocrine
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Pancreas (endocrine)
Eye
Eye
Eye
Eye
Eye
Eye
Eye

Adenoma, islet cell
Adenoma, acinar-islet cell
Carcinoma, islet cell
Carcinoma, acinar-islet cell
Apoptosis
Atrophy
Fibroplasia
Fibrosis
Infiltrate, inflammatory cell
Inflammation
Mitotic figures, increased

Special Senses

Eye

Single cell necrosis

Special Senses
Special Senses

EyeEyelidSpecial Senses
Special Senses
Special Senses

EyelidEyelidEyelidSpecial Senses

EyelidNeovascularization
Infiltrate, inflammatory cell,
eyelidInflammation, eyelid
Atrophy, Meibomian gland
Infiltrate, inflammatory cell,
Meibomian gland
Inflammation, Meibomian glandSpecial Senses

EyelidSpecial Senses
Special Senses
Special Senses

Cornea; Conjunctiva
CorneaCornea; Conjunctiva

Inflammation, granulomatous,
Meibomian gland
Atrophy, epithelium
Attenuation, endothelium
Cyst, inclusion

Modifier(s)SynonymElongated or irregular islet type;
Focal (single islet); Multifocal(several islets); Diffuse (mostislets)StatusPublished

Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working GroupSpecial Senses
Special Senses
Special Senses
Special Senses
Special Senses

OrgansCornea; Conjunctiva
Cornea; Conjunctiva
CorneaCorneaCorneaSpecial Senses

Cornea; Conjunctiva

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Cornea; Conjunctiva
CorneaCorneaCorneaCornea; Conjunctiva
CorneaSpecial Senses

Special Senses
Special Senses
Special Senses
Special Senses

Filtration angle/Trabecularmeshwork
Filtration angle/Trabecularmeshwork
Anterior chamber; Aqueous
humor
Anterior chamber; Aqueous
humor
Uvea; Iris; Ciliary body
Uvea; Iris; Ciliary body
Uvea; Iris; Ciliary body
Uvea; Iris; Ciliary bodySpecial Senses
Special Senses
Special Senses
Special Senses

Uvea; Iris; Ciliary body
Uvea; Ciliary body
Uvea; Iris; Ciliary body
Uvea; Iris; Ciliary bodySpecial Senses
Special Senses
Special Senses

LesionEdema
Erosion/ulcer
Fibroplasia
Fibrosis, stroma
Hypertrophy, Descemet's
membrane
Infiltrate, inflammatory cell,
conjunctiva
Inflammation
Keratinization
Mineralization
Neovascularization
Pigment
Vacuolation, epithelium or
endothelium
Malformation, filtration angle

Modifier(s)Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published

Narrowed filtration angle

Published

Inflammation

Published

Proteineous fluid

Published

Adhesion, iris
Hypoplasia, ciliary body
Malformation, iris
Persistent pupillary membrane

Published
Published
Published
Published

Atrophy, iris
Atrophy, ciliary bodyCongestion
Infiltrate, inflammatory cell

Published
Published
Published
PublishedOrgan Working GroupSpecial Senses
Special Senses

OrgansUvea; Iris; Ciliary body
Uvea; Iris; Ciliary bodySpecial Senses

Uvea; Iris; Ciliary bodySpecial Senses
Special Senses

Lens
Lens

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Lens
Lens
Lens
Lens
Lens
Lens
Lens
Lens
Lens

Special Senses

Vitreous

Special Senses
Special Senses

Vitreous
Vitreous

Special Senses
Special Senses
Special Senses

Vitreous
Vitreous
Vitreous

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Vitreous
Vitreous
Vitreous
Vitreous
RetinaLesionModifier(s)Inflammation
Pigment, increased/decreased,iris
Vacuolation, cytoplasm,
epithelium
Degeneration, lens fiber
Dislocation, lens, anterior orposterior
Fibroplasia, lens epithelium
Hypertrophy, lens capsule
Hypertrophy, lens epithelium
Hypertrophy, lens fiber
Inflammation, lensMineralization, lens fiber
Necrosis, lens epithelium
Rupture, lens capsule
Vacuolation, lens epithelium orlens fiber
Aplasia, vitreous
Persistent hyaloid vessels
Persistent hyperplastic primary
vitreous
Fibroplasia; Vitreous fibrosis
Hemorrhage
Pigment, macrophage,
hemosiderin
Infiltrate, inflammatory cell
Inflammation
Metaplasia, bone or cartilage
Mineralization, vitreous
Retinal rosettes

Synonym

StatusPublished
Published
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
Published
Published
Published
PublishedOrgan Working GroupSpecial Senses
Special Senses

OrgansRetinaRetinaLesionRetinal folds
Atrophy, inner retina

Special Senses

RetinaAtrophy, outer retina

Special Senses

RetinaAtrophy, retina, global

Special Senses
Special Senses

RetinaRetinaSpecial Senses

RetinaDetachment, retina
Displacement, photoreceptor
nucleiFibroplasia, retina or epiretina

Special Senses

RetinaGlial cells, increased number

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

RetinaRetinaRetinaRetinaRetinaInfiltrate, inflammatory cell
Inflammation
Mineralization
Myelin, increased
Single cell necrosis

Special Senses
Special Senses

RetinaRetinaPigment, increased
Vacuolation, cytoplasm

Special Senses
Special Senses

RetinaRetinaVacuolation, extracellular
Arteriolar loop, pre-retina

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

RetinaUvea; Choroid
RetinaOptic nerve
Optic nerve

Hemorrhage
Neovascularization
Neovascularization
AtrophyDegeneration, axon

Modifier(s)Synonym

StatusPublished
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Modified after
publication
Published
Modified after
publication
Published
Modified after
publication
Published
Published
Published
Published
Modified after
publication

Organ Working GroupSpecial Senses
Special Senses

Organs
Optic nerve
Optic nerve

LesionDemyelination
Glial cells, increased number

Special Senses
Special Senses
Special Senses
Special Senses

Infiltrate, inflammatory cell
Inflammation
Vacuolation
Atrophy

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Optic nerve
Optic nerve
Optic nerve
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
Retinal pigment epithelium(RPE)
ScleraScleraScleraScleraCornea; Conjunctiva
Cornea; Conjunctiva

Special Senses

Cornea; Conjunctiva

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Deposits, extracellular matrix,
subretina
Fibroplasia, subretina
Hypertrophy, RPE

Modifier(s)Synonym

StatusPublished
Modified after
publication
Published
Published
Published
Published
Published
Modified after
publication
Published

Inclusions (intracytoplasmic
accumulation), RPE
Necrosis

Published

Pigment, decreased

Modified after
publication
Modified after
publication
Published

Pigment, increased
Polarity, loss, RPE
Atrophy
Infiltrate, inflammatory cell
Inflammation
Metaplasia, bone or cartilage
Dermoid, ocular
Hyperplasia/hypertrophy,
endothelium
Hyperplasia, squamous cell

Published

Published
Published
Published
Published
Published
Published
PublishedOrgan Working GroupSpecial Senses

LesionProliferation, trabecularmeshwork (TM)Hyperplasia, melanocyte
Hyperplasia, lens epithelium
Hyperplasia, RPE

Special Senses
Special Senses
Special Senses

OrgansFiltration angle/Trabecularmeshwork
Uvea
Lens
Retinal pigment epithelium(RPE)
Cornea; Conjunctiva
Cornea; Conjunctiva
Uvea

Special Senses

Uvea

Melanoma, uvea

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Uvea
Optic nerve
Optic nerve
Optic nerve
Optic nerve
Optic nerve
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS

Schwannoma, intraocular
Meningioma, benign
Meningioma, malignant
Schwannoma, benign
Schwannoma, malignant
Glioma (Astrocytoma), benign
Apoptosis

Special Senses
Special Senses
Special Senses

Special Senses

Special Senses

Papilloma, squamous cell
Carcinoma, squamous cell
Leiomyoma, uvea

Modifier(s)Synonym

StatusPublished
Published
Published
Published
Published
Published
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published
Published
Published

Single cell necrosis

Modified after
publication

Degeneration

PublishedOrgan Working GroupSpecial Senses

Special Senses

Special Senses

Special Senses

Special Senses

Special Senses

Special Senses

Special Senses

OrgansHarderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS

LesionRegeneration

Modifier(s)Synonym

StatusPublished

Hypertrophy

Published

Atrophy

Published

Hemorrhage

Published

Dilatation

Modified after
publication

Cyst

Published

Infiltrate, inflammatory cell

Published

Inflammation

PublishedOrgan Working GroupSpecial Senses

Special Senses
Special Senses

Special Senses

Special Senses
Special Senses

Special Senses
Special Senses
Special Senses
Special Senses

Special Senses

Special Senses
Special Senses
Special Senses

OrgansHarderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland
Extraorbital lacrimal gland;
Intraorbital lacrimal gland;
Lacrimal gland, NOS
Harderian gland; Extraorbital
lacrimal gland; Intraorbital
lacrimal gland; Lacrimal gland,
NOS
Harderian gland

LesionInflammation, granulomatous

Modifier(s)Synonym

StatusPublished

Extraorbital lacrimal gland;
Intraorbital lacrimal gland;
Lacrimal gland, NOS
Nasolacrimal duct

Hyperplasia, acinar cell

Harderian gland
Harderian gland
Extraorbital lacrimal gland;
Intraorbital lacrimal gland;
Lacrimal gland, NOS
Extraorbital lacrimal gland;
Intraorbital lacrimal gland;
Lacrimal gland, NOS
Nasolacrimal duct
Nasolacrimal duct
Main olfactory epithelium(MOE)

Adenoma
Adenocarcinoma
Adenoma

Modified after
publication
Published
Published
Published

Adenocarcinoma

Published

Papilloma, squamous cell
Carcinoma, squamous cell
Atrophy, MOE

Published
Published
Published

Porphyrin, increased
Karyomegaly

Published
Published

Cytoplasmic alteration, acinar

Modified after
publication

Hyperplasia, acinar cell

Modified after
publication
Modified after
publication

Hyperplasia, epithelium

Organ Working GroupSpecial Senses

Special Senses
Special Senses
Special Senses
Special Senses

OrgansMain olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Vomeronasal organ (VNO)
Vomeronasal organ (VNO)
Vomeronasal organ (VNO)
Vomeronasal organ (VNO)

Special Senses
Special Senses

Vomeronasal organ (VNO)
Vomeronasal organ (VNO)

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

LesionDegeneration, MOE

Modifier(s)Synonym

StatusPublished

Erosion/ulcer, MOE

Published

Apoptosis, MOE

Published

Necrosis; Single cell necrosis,
MOE
Regeneration, MOE

Published

Infiltrate, inflammatory cell,
MOE
Inflammation, MOE

Published

Edema, MOE

Published

Hemorrhage, MOE

Published

Thrombus, MOE

Published

Eosinophilic globules, MOE

Published

Corpora amylacea, MOE

Published

Atrophy, VNO
Degeneration, VNO
Apoptosis, VNO
Necrosis; Single cell necrosis,
Single cell
VNO
Regeneration, VNO
Regeneration, neuroepithelium,
VNO

Published
Published
Published
Published

Published

Published

Published
Modified after
publication

Organ Working GroupSpecial Senses

OrgansVomeronasal organ (VNO)

Special Senses
Special Senses
Special Senses

Vomeronasal organ (VNO)
Vomeronasal organ (VNO)
Vomeronasal organ (VNO)

Special Senses
Special Senses
Special Senses
Special Senses

Septal organ of Masera (SOM)
Septal organ of Masera (SOM)
Septal organ of Masera (SOM)
Grueneberg ganglion (GG)

Special Senses

Grueneberg ganglion (GG)

Special Senses
Special Senses

Grueneberg ganglion (GG)
Grueneberg ganglion (GG)

Special Senses
Special Senses

Grueneberg ganglion (GG)
Olfactory bulb

Special Senses
Special Senses

Olfactory bulb
Olfactory bulb

Special Senses
Special Senses

Olfactory bulb
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Main olfactory epithelium(MOE)
Vomeronasal organ (VNO)
Septal organ of Masera (SOM)

Special Senses
Special Senses
Special Senses
Special Senses

LesionInfiltrate, inflammatory cell,
VNO
Inflammation, VNO
Edema, VNO
Dilatation/diverticulum, VNO
Atrophy, SOM
Degeneration, SOM
Apoptosis, SOM
Degeneration/necrosis,
ganglion cells (GG)
Degeneration, epithelium (GG)

Modifier(s)Synonym

StatusPublished
Published
Published
Modified after
publication
Published
Published
Published
Published
Published

Erosion/ulcer, epithelium (GG)
Infiltrate, inflammatory cell
(GG)
Inflammation (GG)
Degeneration/vacuolation,
olfactory bulb
Apoptosis, olfactory bulb
Infiltrate, inflammatory cell,
olfactory bulb
Inflammation, olfactory bulb
Hyperplasia, MOE

Published
Modified after
publication
Published
Published

Metaplasia, respiratory, MOE

Published

Metaplasia, squamous cell,
MOE
Hyperplasia, VNO
Metaplasia, squamous cell,
SOM

Published

Published
Published
Published
Published

Published
PublishedOrgan Working GroupSpecial Senses
Special Senses

OrgansMain olfactory epithelium(MOE)
Vomeronasal organ (VNO)

Special Senses

Ear, external

Special Senses

Ear, external

Special Senses

Ear, external

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Ear, externalEar, externalEar, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle

Special Senses
Special Senses

Ear, middle
Ear, middle

Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses
Special Senses

Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle
Ear, middle

LesionCarcinoma, neuroepithelial,
MOE
Carcinoma, neuroepithelial,
VNO
Perforation, tympanic
membrane
Inflammation, auricularcartilage
Inflammation, external ear
canal
Debris, external ear canal
Cyst, tympanic membrane
Mineralization
Ulcer
Necrosis, bone
Necrosis, tympanic membrane
Infiltrate, inflammatory cell
Inflammation, middle ear
Inflammation, middle ear,catarrhal
Metaplasia, squamous cell
Metaplasia, tall cuboidal tocolumnar
Fibrosis
Granulation tissue
Inflammation, granulomatous
Hemorrhage
Edema
Cyst
Cholesteatoma
Atrophy, bone
New bone formation

Modifier(s)Synonym

StatusPublished
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working GroupSpecial Senses

Organs
Ear, innerSpecial Senses

Ear, inner

LesionModifier(s)Degeneration, hair cells and/or
epithelium
Hair cell, decreased number

Special Senses
Special Senses
Special Senses
Special Senses

Ear, inner
Ear, inner
Ear, inner
Ear, inner

Necrosis, hair cell
Necrosis, cartilage
Necrosis, vestibular organ
Necrosis, neuron

Special Senses

Ear, inner

Degeneration, axon

Special Senses

Ear, innerSpecial Senses

Ear, innerSpecial Senses

Ear, innerSpecial Senses
Special Senses
Special Senses
Special Senses

Ear, inner
Ear, inner
Ear, inner
Ear, innerSpecial Senses
Special Senses
Special Senses
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

Ear, inner
Ear, inner
Ear, inner
General hematolymphoid
General hematolymphoid
General hematolymphoid

Hematolymphoid System

General hematolymphoid

Cellularity, decreased, spirallimbus, spiral ligament, and/or
stria vascularis
Cellularity, decreased, spiralganglion
Vacuolation, haircell/supporting cell
Vacuolation, stria vascularis
Inflammation, inner ear
Fibrosis
Otolith loss, disorganization, or
disruption
Edema
Hemorrhage
New bone formation
Amyloid
Aplasia/hypoplasia
Apoptosis, increased,
lymphocyte
Cellularity, increased, mast cell

Synonym

StatusPublished
Modified after
publication
Published
Published
Published
Modified after
publication
Modified after
publication
Modified after
publication
Modified after
publication
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Hematolymphoid System

OrgansGeneral hematolymphoid

LesionExtramedullary hematopoiesis(EMH)
Infiltrate (indicate modifier)Hematolymphoid System

General hematolymphoid

Hematolymphoid System

General hematolymphoid

Inflammation (indicate
modifier)

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

General hematolymphoid
General hematolymphoid
General hematolymphoid

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

General hematolymphoid
General hematolymphoid
General hematolymphoid
General hematolymphoid
General hematolymphoid
General hematolymphoid
General hematolymphoid

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

General hematolymphoid
Bone marrow
Bone marrow

Inflammation, neutrophil
Abscess
Inflammation, mononuclear
cell, lymphocyte, monocyte,
eosinophil, mixed cell,
lymphoplasmacytic, or
pyogranulomatous
Inflammation, granulomatous
Granuloma
Metaplasia, osseous
Mineralization
Necrosis
Pigment, macrophage
Tingible body macrophage,
increased
Vacuolation, macrophage
Angiectasis
Cellularity, decreased,adipocyte

Modifier(s)Erythroid; Myeloid
Neutrophil; Eosinophil; Mast
cell; Monocyte; Macrophage;
Mixed cell
Neutrophil; Mononuclear cell;
Lymphocyte; Monocyte; Mixed
cell; Lymphoplasmacytic;
Pyogranulomatous;
Granulomatous; Acute;
Subacute; Chronic; Chronic
activeSynonym

StatusPublished
Published

Published

Published
Published
Published

Lymphoid; Lymphocyte

Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Hematolymphoid System

OrgansBone marrow

LesionCellularity, decreased, bonemarrow

Hematolymphoid System

Bone marrow

Dyshematopoiesis

Hematolymphoid System
Hematolymphoid System

Bone marrow
Bone marrow

Hematolymphoid System
Hematolymphoid System

Bone marrow
Bone marrow

FibrosisHypersegmentation,
granulocyte
Serous atrophy of fat
Cellularity, increased, adipocyte

Hematolymphoid System

Bone marrow

Cellularity, increased, bonemarrow

Hematolymphoid System

Bone marrow

Hematolymphoid System

Bone marrow

Cellularity, increased,
macrophage
Cellularity, increased, mast cell

Hematolymphoid System

ThymusHematolymphoid System

ThymusHematolymphoid System

ThymusHematolymphoid System

ThymusHematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

ThymusThymusThymusThymusApoptosis, increased,
lymphocyte
Cellularity, decreased,
lymphocyte
Corticomedullary ratio,
decreased
Corticomedullary ratio,
increased
Cyst, epithelial
Ectopic tissue, parathyroid
Ectopic tissue, (specify tissue)
Ectopic tissue, thymus

Modifier(s)Erythroid; Myeloid(granulocytic, monocytic);
Megakaryocytic; NOS
Erythroid; Myeloid(granulocytic, monocytic);
Megakaryocytic; NOS

Synonym

StatusPublished

Published

Published
Published
Published
Published
Erythroid; Myeloid(granulocytic, monocytic);
Megakaryocytic; Lymphocytic;
Plasma cell; NOS
Tingible body; Pigmented;
Vacuolated; Aggregates

Published

Published
Published
Published
Published
Published
Published
Published
Published
Published
PublishedOrgan Working Group
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

OrgansThymusThymusThymusHematolymphoid System
Hematolymphoid System

ThymusThymusHematolymphoid System

ThymusHematolymphoid System

ThymusHematolymphoid System
Hematolymphoid System

ThymusSpleenHematolymphoid System

SpleenHematolymphoid System
Hematolymphoid System

SpleenSpleenHematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

SpleenSpleenSpleenSpleenSpleenSpleenHematolymphoid System

SpleenHematolymphoid System

SpleenHematolymphoid System

SpleenLesionModifier(s)Hypoplasia
Involution, age-related
Loss of corticomedullary
distinction
Necrosis, lymphocyte
Cellularity, increased, epithelial
cell
Cellularity, increased,
T cell; B cell
lymphocyte
Epithelium-free areas, increased

Synonym

StatusPublished
Published
Published
Published
Published
Published
Published

Thymic corpuscles, increased
Apoptosis, increased,
lymphocyte
Cellularity, decreased, white
Lymphoid; Lymphocyte
pulp
Angiectasis
Cellularity, decreased, red pulp

Published
Published

Congestion
Contraction
Ectopic tissue, spleen
Erythrophagocytosis
Fibrosis
Aggregates, macrophage,
Vacuolated; Pigmented
increased
Cellularity, increased, plasma
cell, white pulp
Cellularity, increased, white
Lymphoid; Lymphocyte
pulp
Cellularity, increased, adipocyte

Published
Published
Published
Published
Published
Published

Published
Published
Published

Published
Published
PublishedOrgan Working Group
Hematolymphoid System

OrgansSpleenHematolymphoid System

SpleenHematolymphoid System

SpleenHematolymphoid System

SpleenHematolymphoid System

SpleenHematolymphoid System

SpleenHematolymphoid System
Hematolymphoid System

SpleenLymph node

Hematolymphoid System

Lymph node

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

Lymph node
Lymph node
Lymph node
Lymph node

Hematolymphoid System

Lymph node

Hematolymphoid System

Lymph node

Hematolymphoid System

Lymph node

Hematolymphoid System

Lymph node

LesionModifier(s)Cellularity, increased,
Tingible body; Pigmented;
macrophage
Vacuolated; Aggregates
Cellularity, increased, mast cell
Cellularity, increased,mesothelial cell
Cellularity, increased, plasma
cell, red pulp
Cellularity, increased, stromal
cell
Extramedullary hematopoiesis,
increased
Hyperplasia, nodular
Apoptosis, increased,
lymphocyte
Cellularity, decreased,
Lymphoid; Lymphocyte
lymphocyte
Dilatation, sinus
Erythrocytes, intrasinusoidal
Lymphangiectasis
Aggregates, increased,
Pigmented; Vacuolated
macrophage
Cellularity, increased,interdigitating dendritic cell
Cellularity, increased,
Lymphoid; Lymphocyte
lymphocyte
Cellularity, increased, plasma
cell
Cellularity, increased, stromalcell

Synonym

StatusPublished
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PublishedOrgan Working Group
Hematolymphoid System

OrgansLymph node

LesionHyperplasia, angiomatous

Hematolymphoid System

Lymph node

Published

Hematolymphoid System

Lymph node

Hematolymphoid System

Lymph nodeHypertrophy/hyperplasia, highendothelial venule (HEV)
Cellularity, increased,
Pigmented; Vacuolated
macrophage, intrasinusoidal
Cellularity, increased, mast cell

Hematolymphoid System
Hematolymphoid System

Lymph node
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)
MALT (mucosa-associatedlymphoid tissue)

Fibrosis
Cellularity, decreased,
lymphocyte
Degeneration, follicleassociated epithelium
Hyaline material

Published
Published

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

Modifier(s)Synonym
Lymphatic (if vessels contain
only proteinaceous fluid and noerythrocytes)

Lymphoid; Lymphocyte

StatusPublished

Published
Published

Published
Published

Lymphangiectasis

Published

Aggregates, macrophage

Published

Cellularity, increased,
lymphocyte
Cellularity, increased,
Tingible body; Pigmented;
macrophage
Vacuolated; Aggregates
Hyperplasia, follicle-associatedepithelium
Hyperplasia, goblet cell, follicleassociated epithelium
Hypertrophy/hyperplasia, highendothelial venule (HEV)
Metaplasia, squamous, follicleassociated epithelium

Published
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PublishedOrgan Working Group
Hematolymphoid System

OrgansOther lymphoid tissues

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System

Other lymphoid tissues
Hematolymphoid neoplasms
Hematolymphoid neoplasms
Hematolymphoid neoplasms

LesionTertiary lymphoid structures(TLSs)
SALCs, increased
Leukemia, erythroid
Leukemia, megakaryocytic
Leukemia, myeloid

Hematolymphoid System
Hematolymphoid System

Hematolymphoid neoplasms
Hematolymphoid neoplasms

Leukemia, NOS
Lymphoma

Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Hematolymphoid System
Nervous System
Nervous System

Hematolymphoid neoplasms
Hematolymphoid neoplasms
Hematolymphoid neoplasms
Hematolymphoid neoplasms
ThymusThymusSpinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord

Histiocytic sarcoma
Leukemia, mast cell
Tumor, mast cell, benign
Tumor, mast cell, malignant
Thymoma, benign
Thymoma, malignant
Autophagy, neuron, ganglion
Degeneration, nerve fiber

Modifier(s)Neutrophilic; Eosinophilic;
Basophilic; Myelomonocytic;
Monocytic; NOS (not otherwise
specified)
Subtype modifiers:
Lymphoblastic; Pleomorphic;
Follicular; Immunoblastic;
Lymphocytic; Plasmacytic;
Epitheliotrophic cutaneous Tcell; Marginal zone; LGL; NOS.
Cell type modifiers: T cell; B cell.
Qualifier (optional): Leukemic(can be used when there is an
obvious leukemia present
judging from the peripheral
blood smears or tissue sections)

Epithelial; Spindeloid
Epithelial; Spindeloid

Synonym

StatusPublished
Published
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Published
PublishedOrgan Working Group
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System
Nervous System

OrgansBrain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord
Peripheral nerve
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord
Brain; Cerebrum; Cerebellum;
Spinal cord; Peripheral nerve

LesionRadiculoneuropathy

Modifier(s)Synonym

StatusPublished

Accumulation, laminar,
Schwann cell
Accumulation, matrix

Published

Ectopic tissue

Published

Renaut body
Hyperplasia, glial cell, nototherwise specified (NOS)
Glioma, not otherwise specified(NOS)
Cellularity, decreased, neuron

Published
Published

Necrosis/inflammation, media
or wall, artery

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Published

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Published