FY2017

List of Publications FY 2017
A. WPI papers(1) Original Articles
1. Honjoh S, Ihara A, Kajiwara Y, Yamamoto T, Nishida E (2017) The Sexual Dimorphism of Dietary
Restriction Responsiveness in Caenorhabditis elegans. Cell Rep 21(13): 3646–3652.
doi:10.1016/j.celrep.2017.11.108
2. Liu J, Zhang MQ, Wu X, Lazarus M, Cherasse Y, Yuan MY, Huang ZL, Li RX (2017) Activation of
Parvalbumin Neurons in the Rostro-Dorsal Sector of the Thalamic Reticular Nucleus Promotes Sensitivity
to Pain in Mice. Neuroscience 16(366): 113-123. doi:10.1016/j.neuroscience.2017.10.013
3. Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T (2017)
Prostaglandin D-2 metabolite in urine is an index of food allergy. Sci Rep 7(1): 17687.
doi:10.1038/s41598-017-17798-w
4. Ogawa Y, Kanda T, Vogt K, Yanagisawa M (2017) Anatomical and electrophysiological development of the
hypothalamic orexin neurons from embryos to neonates. J. Comp. Neurol. 525(18): 3809-3820.
doi:10.1002/cne.24261
5. Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller
PM, Saper CB (2017) A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron
96(5): 1153-1167. doi:10.1016/j.neuron.2017.10.009
6. Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H,
Higami Y (2017) Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric
restriction. FEBS Lett. 591(24): 4067-4073. doi:10.1002/1873-3468.12914
7. Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y,
Fujii R, Usui T, Kulathunga K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T,
Takahashi S (2017) MafB is a critical regulator of complement component C1q. Nat. Commun. 8(1): 1700.
doi:10.1038/s41467-017-01711-0
8. Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017) Orexin
modulates behavioral fear expression through the locus coeruleus. Nat. Commun. 8(1): 1606.
doi:10.1038/s41467-017-01782-z
9. Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S (2017) T
cells upon activation promote endothelin 1 production in monocytes via IFN-gamma and TNF-alpha. Sci
Rep 7(1): 14500. doi:10.1038/s41598-017-14202-5
10. Um MY, Kim S, Jin YH, Yoon M, Yang H, Lee J, Jung J, Urade Y, Huang ZL, Kwon S, Cho S (2017) A novel
neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye
movement sleep in mice through histamine H-1 receptors. Mol. Nutr. Food. Res. 61(11).
doi:10.1002/mnfr.201700316
11. Kutsumura N, Shibuya K, Yamaguchi H, Saito T (2017) n-Butyllithium-promoted regioselective eliminationof vicinal bis-triflate having an adjacent ether oxygen. Tetrahedron Lett. 58(43): 4099–4102.
doi:10.1016/j.tetlet.2017.09.036
12. Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R,
Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M (2017) Klf5 maintains the balance ofprimitive endoderm versus epiblast specification during mouse embryonic development by suppression of
Fgf4. Development 144(20): 3706-3718. doi:10.1242/dev.150755

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13. Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d'Exaerde AD, Li RX,
Huang ZL (2017) Striatal adenosine A(2A) receptor neurons control active-period sleep via parvalbumin
neurons in external globus pallidus. eLife 6: e29055. doi:10.7554/eLife.29055
14. Suda H, Kanbayashi T, Ito SU, Sagawa Y, Imanishi A, Tsutsui K, Takahashi J, Kikuchi Y, Takahashi Y,
Shimizu T (2017) Residual effects of eszopiclone on daytime alertness, psychomotor, physicalperformance and subjective evaluations. Sleep Biol Rhythms 15(4): 311–316.
doi:10.1007/s41105-017-0112-z
15. Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schiffmann SN, d'Exaerde
AD, Urade Y, Qu WM, Huang ZL, Lazarus M (2017) Slow-wave sleep is controlled by a subset of nucleus
accumbens core neurons in mice. Nat. Commun. 8(1): 734. doi:10.1038/s41467-017-00781-4
16. Yamamoto N, Okada T, Harada Y, Kutsumura N, Imaide S, Saitoh T, Fujii H, Nagase H (2017) The
application of a specific morphinan template to the synthesis of galanthamine. Tetrahedron. 73(39):5751-5758. doi:10.1016/j.tet.2017.08.014
17. Fujii H, Shimada N, Ohtawa M, Karaki F, Koshizuka M, Hayashida K, Kamimura M, Makino K, Nagamitsu T,
Nagase H (2017) Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside,
and alkaloid derivatives. Tetrahedron 73(36): 5425-5429. doi:10.1016/j.tet.2017.07.047
18. Malyshevskaya O, Aritake K, Kaushik MK, Uchiyama N, Cherasse Y, Kikura-Hanajiri R, Urade Y (2017)
Natural (Delta(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through thecannabinoid CB1 receptor. Sci Rep 7(1): 10516. doi:10.1038/s41598-017-10447-2
19. Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa
Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H (2017) Essential structure oforexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Bioorg. Med. Chem. Lett. 27(17): 4176-4179. doi:10.1016/j.bmcl.2017.07.011
20. Tsuneoka Y, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Neurotransmitters andneuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male
mouse. Sci Rep 7(1): 9809. doi:10.1038/s41598-017-10213-4
21. Kutsumura N, Ohshita R, Horiuchi J, Tateno K, Yamamoto N, Saitoh T, Nagumo Y, Kawai H, Nagase H(2017) Synthesis of heterocyclic compounds with adamantane-like cage structures consisting ofphosphorus, sulfur, and carbon. Tetrahedron 73(34): 5214-5219. doi:10.1016/j.tet.2017.07.016
22. Kaushik MK, Aritake K, Takeuchi A, Yanagisawa M, Urade Y (2017) Octacosanol restores stress-affected
sleep in mice by alleviating stress. Sci Rep 7(1): 8892. doi:10.1038/s41598-017-08874-2
23. Wakai E, Aritake K, Urade Y, Fujimori K (2017) Prostaglandin D-2 enhances lipid accumulation throughsuppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Biochem. Biophys. Res. Commun.
490(2): 393-399. doi:10.1016/j.bbrc.2017.06.053
24. Kutsumura N, Koyama Y, Nagumo Y, Nakajima R, Miyata Y, Yamamoto N, Saitoh T, Yoshida N, Iwata S,
Nagase H (2017) Antitrichomonal activity of delta opioid receptor antagonists, 7-benzylidenenaltrexone
derivatives. Bioorg. Med. Chem. 25(16): 4375-4383. doi:10.1016/j.bmc.2017.06.026
25. Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC,
Nakamura M, Urade Y, Murata T (2017) Mast cell-derived prostaglandin D-2 attenuates anaphylactic
reactions in mice. J. Allergy Clin. Immunol. 140(2): 630–632.e9. doi:10.1016/j.jaci.2017.02.030
26. Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M (2017) Activation ofventral tegmental area dopamine neurons produces wakefulness through dopamine D-2-like receptors inmice. Brain Struct. Funct. 222(6): 2907-2915. doi:10.1007/s00429-017-1365-7

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27. Watanabe Y, Hayashida K, Saito D, Takahashi T, Sakai J, Nakata E, Kanda T, Iwai T, Hirayama S, Fujii H,
Yamakawa T, Nagase H (2017) Design and synthesis of novel delta opioid receptor agonists with anazatricyclodecane skeleton for improving blood-brain barrier penetration. Bioorg. Med. Chem. Lett.
27(15): 3495-3498. doi:10.1016/j.bmcl.2017.05.072
28. Shitara H, Cao LQ, Yamaguchi M, Yonekawa H, Taya C (2017) Establishment of a heteroplasmic mousestrain with interspecific mitochondrial DNA haplotypes and improvement of a PCR-RFLP-based
measurement system for estimation of mitochondrial DNA heteroplasmy. Transgenic Res. 26(4): 559-565.
doi:10.1007/s11248-017-0009-2
29. Kodani S, Soya S, Sakurai T (2017) Excitation of GABAergic Neurons in the Bed Nucleus of the Stria
Terminalis Triggers Immediate Transition from Non-Rapid Eye Movement Sleep to Wakefulness in Mice. J.
Neurosci. 37(30): 7164-7176. doi:10.1523/JNEUROSCI.0245-17.2017
30. Iwayama K, Kawabuchi R, Nabekura Y, Kurihara R, Park I, Kobayashi M, Ogata H, Kayaba M, Omi N, Satoh
M, Tokuyama K (2017) Exercise before breakfast increases 24-h fat oxidation in female subjects. PLoS
One 12(7): e0180472. doi:10.1371/journal.pone.0180472
31. Takahashi J, Kanbayashi T, Uemura SI, Sagawa Y, Tsutsui K, Takahashi Y, Omori Y, Imanishi A, Takeshima
M, Satake M, Shimizu T (2017) Residual effects of eszopiclone and placebo in healthy elderly subjects: arandomized double-blind study. Sleep Biol. Rhythms 15(3): 235-241. doi:10.1007/s41105-017-0101-2
32. Takei K, Han S, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H,
Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H (2017) Selective peroxisome
proliferator-activated receptor-alpha modulator K-877 efficiently activates the peroxisome proliferatoractivated receptor-alpha pathway and improves lipid metabolism in mice. J. Diabetes. Investig. 8(4): 446452. doi:10.1111/jdi.12621
33. Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han S, Takeuchi Y, Aita Y,
Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N Shimano H (2017)
Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass andIncreasing Insulin Secretory Capacity. Diabetes 66(7): 1833-1846. doi:10.2337/db16-1277
34. Hayashida K, Hirayama S, Iwai T, Watanabe Y, Takahashi T, Sakai J, Nakata E, Yamakawa T, Fujii H,
Nagase H (2017) Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent
agonistic activities. Bioorg. Med. Chem. Lett. 27(12): 2742-2745. doi:10.1016/j.bmcl.2017.04.059
35. Ku CJ, Sekiguchi JM, Panwar B, Guan YF, Takahashi S, Yoh K, Maillard I, Hosoya T, Engel JD (2017) GATA3
Abundance Is a Critical Determinant of T Cell Receptor beta Allelic Exclusion. Mol. Cell. Biol. 37(12):e00052-17. doi:10.1128/MCB.00052-17
36. Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S,
Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M (2017) Nonpeptide orexin
type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc. Natl. Acad.
Sci. U.S.A. 114(22): 5731-5736. doi:10.1073/pnas.1700499114
37. Saito H, Cherasse Y, Suzuki R, Mitarai M, Ueda F, Urade Y (2017) Zinc-rich oysters as well as zinc-yeastand astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trialof healthy individuals. Mol. Nutr. Food. Res. 61(5). doi:10.1002/mnfr.201600882
38. Toyama T, Saitoh T, Takahashi Y, Oka K, Citterio D, Suzuki K, Nishiyama S (2017) Click Reaction Based on
the Biosynthesis of Firefly Luciferin. Chem. Lett. 46(5): 753-755. doi:10.1246/cl.170094
39. Li JJ, Kong DP, Wang Q, Wu W, Tang YP, Bai TT, Guo L, Wei LM, Zhang QQ, Yu Y, Qian YT, Zuo SK, Liu, GZ,
Liu, Q, Wu, S, Zang, Y, Zhu, Q, Jia DL, Wang YY, Yao WY, Ji Y, Yin HY, Nakamura M, Lazarus M, Breyer

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FY2017

RM, Wang LF, Yu Y (2017) Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D
prostanoid receptor 1 activation. EMBO Mol. Med. 9(5): 571-588. doi:10.15252/emmm.201606987
40. Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet
BK, Roth BL (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat. Chem.
Biol. 13(5): 529-536. doi:10.1038/nchembio.2334
41. Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M (2017)
Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing
amygdala activity. Proc. Natl. Acad. Sci. U.S.A. 114(17): E3526-E3535. doi:10.1073/pnas.1614552114
42. Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani K, Miwa Y, Matsumoto K,
Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M (2017) Fluorescence andBioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Sci Rep 7: 46597.
doi:10.1038/srep46597
43. Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M (2017) Effects of repeated treatment with adelta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav. Brain
Res. 323: 11-14. doi:10.1016/j.bbr.2016.11.008
44. Purple RJ, Sakurai T, Sakaguchi M (2017) Auditory conditioned stimulus presentation during NREM sleep
impairs fear memory in mice. Sci Rep 7: 46247. doi:10.1038/srep46247
45. Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y (2017)
Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain ofmouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One 12(4): e0175452.
doi:10.1371/journal.pone.0175452
46. Takei K, Nakagawa Y, Wang Y, Han S, Satoh A, Sekiya M, Matsuzaka T, Shimano H (2017) Effects of K-877,
a novel selective PPAR alpha modulator, on small intestine contribute to the amelioration of hyperlipidemia
in low-density lipoprotein receptor knockout mice. J. Pharmacol. Sci. 133(4): 214-222.
doi:10.1016/j.jphs.2017.02.003
47. Park I, Ochiai R, Ogata H, Kayaba M, Hari S, Hibi M, Katsuragi Y, Satoh M, Tokuyama K (2017) Effects of
subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of
the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial. Br. J.
Nutr. 117(7): 979-984. doi:10.1017/S0007114517000587
48. Wang YQ, Li R, Wang DR, Cherasse Y, Zhang Z, Zhang MQ, Lavielle O, McEown K, Schiffmann SN,
d'Exaerde AD, Qu WM, Lazarus M, Huang ZL (2017) Adenosine A(2A) receptors in the olfactory bulb
suppress rapid eye movement sleep in rodents. Brain Struct. Funct. 222(3): 1351-1366.
doi:10.1007/s00429-016-1281-2
49. Zhang BJ, Huang ZL, Chen JF, Urade Y, Qu WM (2017) Adenosine A(2A) receptor deficiency attenuates
the somnogenic effect of prostaglandin D-2 in mice. Acta Pharmacol. Sin. 38(4): 469-476.
doi:10.1038/aps.2016.140
50. Yokosawa M, Kondo Y, Tahara M, Iizuka-Koga M, Segawa S, Kaneko S, Tsuboi H, Yoh K, Takahashi S,
Matsumoto I, Sumida T (2017) T-bet over-expression regulates aryl hydrocarbon receptor-mediated T
helper type 17 differentiation through an interferon (IFN)-independent pathway. Clin. Exp. Immunol.
188(1): 22-35. doi:10.1111/cei.12912
51. Kayaba M, Park I, Iwayama K, Seya Y, Ogata H, Yajima K, Satoh M, Tokuyama K (2017) Energy
metabolism differs between sleep stages and begins to increase prior to awakening. Metab. Clin. Exp. 69:
14-23. doi:10.1016/j.metabol.2016.12.016

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52. Grewe BF, Grundemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li
JZ, Luthi A, Schnitzer MJ (2017) Neural ensemble dynamics underlying a long-term associative memory.
Nature 543(7647): 670-675. doi:10.1038/nature21682
53. Tsuneoka Y, Tsukahara S, Yoshida S, Takase K, Oda S, Kuroda M, Funato H (2017) Moxd1 Is a Marker for
Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala.
Front. Neuroanat. 11: 26. doi:10.3389/fnana.2017.00026
54. Tang J, Shen YJ, Chen GL, Wan QY, Wang K, Zhang J, Qin J, Liu GZ, Zuo SK, Tao B, Yu Y, Wang JW,
Lazarus M, Yu Y (2017) Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing
after myocardial infarction. Nat. Commun. 8: 14656. doi:10.1038/ncomms14656
55. Kong DP, Li JJ, Shen YJ, Liu GZ, Zuo SK, Tao B, Ji Y, Lu AK, Lazarus M, Breyer RM, Yu Y (2017) Niacin
Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2
Receptor Subtype 1. J. Pharmacol. Exp. Ther. 360(3): 435-444. doi:10.1124/jpet.116.238261
56. Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A,
Hosoya T, McHugh TJ, Kuwahara M, Itohara S (2017) Schizophrenia-like phenotypes in mice with NMDA
receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Transl.
Psychiatry 7(2): e1047. doi:10.1038/tp.2017.19
57. Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y (2017) Triethylene glycol, an active componentof Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One 12(2):e0172508. doi:10.1371/journal.pone.0172508
58. Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe
Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M (2017) Design and
Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and
Their Pharmacologies. J. Med. Chem. 60(3): 1018-1040. doi:10.1021/acs.jmedchem.6b01418
59. Mieda M, Hasegawa E, Kessaris N, Sakurai T (2017) Fine-Tuning Circadian Rhythms: The Importance of
Bmal1 Expression in the Ventral Forebrain. Front Neurosci 11: 55. doi:10.3389/fnins.2017.00055
60. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao JH,
Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK (2017) SREBP1
Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.
Cell Metab. 25(2): 412-427. doi:10.1016/j.cmet.2016.11.009
61. Ohtaki Y, Oi Y, Doki S, Kaneko H, Usami K, Sasahara S, Matsuzaki I (2017) Characteristics of Telephone
Crisis Hotline Callers with Suicidal Ideation in Japan. Suicide Life Threat. Behav. 47(1): 54-66.
doi:10.1111/sltb.12264
62. Garcia SV, Libourel PA, Lazarus M, Grassi D, Luppi PH, Fort P (2017) Genetic inactivation of glutamate
neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder. Brain
140(2): 414-428. doi:10.1093/brain/aww310
63. Zhang BJ, Shag SR, Aritake K, Takeuchi A, Urade Y, Huang, ZL, Lazarus M, Qu WM (2017) Interleukin-1βinduces sleep independent of prostaglandin D2 in rats and mice. Neuroscience 340: 258-267.
doi:10.1016/j.neuroscience.2016.09.053
64. Korkutata M, Saitoh T, Feng D, Murakoshi N, Sugiyama F, Cherasse Y, Nagase H, Lazarus M (2017)
Allosteric modulation of adenosine A2A receptors in mice induces slow-wave sleep without cardiovasculareffects. Sleep Medicine 40: e181. doi:10.1016/j.sleep.2017.11.530
65. Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A,
Kitaoka S, Sawa A, Narumiya S, Furuyashiki T (2017) Dopamine D1 receptor subtype mediates acutestress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes tosuppression of stress susceptibility in mice. Mol Psychiatry . doi:10.1038/mp.2017.177

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66. Tsutsui K, Kanbayashi T, Takaki M, Omori Y, Imai Y, Nishino S, Tanaka K, Shimizu T (2017) N-Methyl-Daspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports
and methods for detection. Neuropsychiatr Dis Treat. 13: 339–345. doi:10.2147/NDT.S125800
67. Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N,
Sakashita S, Matsukawa T, Isoda H, Ohkohchi N (2017) Novel non-alcoholic steatohepatitis model withhistopathological and insulin-resistant features. Pathol Int. 68(1): 12-22. doi:10.1111/pin.12612
68. Hamada Y, Tasaki Y, Morita K, Yamamizu K, Narita M, Matsuyama F, Suzuki M, Ikegami D, Arakawa K,
Nagumo Y, Kawata M, Uezono Y, Nagase H, Aoki K, Yamashita JK, Kuzumaki N, Narita M (2017) The κopioid receptor agonist nalfurafine enhances the chemotherapy-induced survival advantage in pancreaticcancer-bearing mice. Jpn. J. Pharm. Palliat. Care Sci 10: 7-12(2) Review articles
69. Shimano H, Sato R (2017) SREBP-regulated lipid metabolism: convergent physiology — divergent
pathophysiology. Nat. Rev. Endocrinol. 13(12):710-730. doi:10.1038/nrendo.2017.91
70. Cherasse Y, Urade Y (2017) Dietary Zinc Acts as a Sleep Modulator Int. J. Mol. Sci. 18(11), 2334.
doi:10.3390/ijms18112334
71. Leprince J, Bagnol D, Bureau R, Fukusumi S, Granata R, Hinuma S, Larhammar D, Primeaux S, Santos
JSD, Tsutsui K, Ukena K, Vaudry H (2017) The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide
and its receptor: IUPHAR Review 24. Br. J. Pharmacol. 174(20):3573-3607. doi:10.1111/bph.13907
72. Greene RW, Bjorness TE, Suzuki A (2017) The adenosine-mediated, neuronal-glial, homeostatic sleep
response. Curr. Opin. Neurobiol. 44:236-242. doi:10.1016/j.conb.2017.05.015
73. Miyazaki S, Liu CY, Hayashi Y (2017) Sleep in vertebrate and invertebrate animals, and insights into thefunction and evolution of sleep. Neurosci. Res. 118: 3-12. doi:10.1016/j.neures.2017.04.017
74. Oishi Y, Lazarus M (2017) The control of sleep and wakefulness by mesolimbic dopamine systems.
Neurosci. Res. 118: 66-73. doi:10.1016/j.neures.2017.04.008
75. Kanda T, Ohyama K, Muramoto H, Kitajima N, Sekiya H (2017) Promising techniques to illuminate
neuromodulatory control of the cerebral cortex in sleeping and waking states. Neurosci. Res. 118: 92103. doi:10.1016/j.neures.2017.04.009(3) Proceedings
76. Asada K, Shimamoto S, Oonoki T, Maruno T, Kobayashi Y, Aritake K, Urade Y, Hidaka Y (2017) Molecular
Recognition Mechanism of Hematopoietic Prostaglandin D Synthase with its Cofactor and Substrate.
Biophys. J. 112(3): 494a. doi:10.1016/j.bpj.2016.11.2675
77. Nakamura T, Maeda S, Harada H, Aritake K, Shimosawa T, Urade Y, Yatomi Y, Murata T (2017) Urinary
Prostaglandin D2 Metabolite Is a Novel Biomarker of Food Allergy. J. Allergy Clin. Immunol. 139(2):AB190. doi:10.1016/j.jaci.2016.12.618
78. Hsiao Y, Tsai C, Lin H, Yu L, Tsai F (2017) Untangling kinase-based signaling interactions in endothelial cell
migration and angiogenesis. Molecular Biology of the Cell

(4) Other English articles

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FY201779. Hayashi Y, Itohara S (2017) Cutting-edge approaches to unwrapping the mysteries of sleep. Neurosci.
Res. 118: 1-2. doi:10.1016/j.neures.2017.04.014
80. Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB (2017) Adenosine and sleep. Handb. Exp/
Pharmacol. doi:10.1007/164_2017_36(5) Articles written in other than English
81. Oishi Y and Lazarus M. (2017) Reward system and sleep/wake [Japanese: 報酬系と睡眠・覚醒]. J.

Clin. Exp. Med. [Japanese: 医学のあゆみ] 263:761-764.

WPI-Related Papers(1) Original Articles
82. Ikeda T, Uno M, Honjoh S, Nishida E (2017) The MYST family histone acetyltransferase complex regulates
stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors.
EMBO Rep. 18(10): e201743907. doi:10.15252/embr.201743907
83. Honjoh S, de Vivo L, Okuno H, Bito H, Tononi G, Cirelli C (2017) Higher Arc Nucleus-to-Cytoplasm Ratio
during Sleep in the Superficial Layers of the Mouse Cortex. Front. Neural Circuits 11: 60.
doi:10.3389/fncir.2017.00060
84. Hoshikawa H, Uno M, Honjoh S, Nishida E (2017) Octopamine enhances oxidative stress resistancethrough the fasting-responsive transcription factor DAF-16/FOXO in C. elegans. Genes to Cells 22(2):210-219. doi:10.1111/gtc.12469
85. Ihara A, Uno M, Miyatake K, Honjoh S, Nishida E (2017) Cholesterol regulates DAF-16 nuclear localizationand fasting-induced longevity in C-elegans. Exp. Gerontol. 87(Pt A): 40-47.
doi:10.1016/j.exger.2016.10.011
86. Tanno S, Tanigawa T, Maruyama K, Eguchi E, Abe T, Saito I (2017) Sleep-related intermittent hypoxia isassociated with decreased psychomotor vigilance in Japanese community residents. Sleep Med. 29: 7-12.
doi:10.1016/j.sleep.2016.08.024
87. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida
Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A,
Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K (2017) CD206(+)
M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte
progenitors. Nat. Commun. 8(1): 286. doi:10.1038/s41467-017-00231-1
88. Chao HW, Doi M, Fustin JM, Chen HT, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N,
Yamaguchi Y, Yasunaga J, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H (2017) Circadianclock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway. Nat. Commun. 8(1):2238. doi:10.1038/s41467-017-02207-7
89. Fustin JM, Karakawa S, Okamura H (2017) Circadian Profiling of Amino Acids in the SCN and Cerebral
Cortex by Laser Capture Microdissection-Mass Spectrometry. J. Biol. Rhythms 32(6): 609-620.
doi:10.1177/0748730417735922
90. Oishi Y, Hayashi S, Isagawa T, Oshima M, Iwama A, Shimba S, Okamura H, Manabe I (2017) Bmal1
regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. Sci Rep
7
IIISFY20177(1): 7086. doi:10.1038/s41598-017-07100-3
91. Kori H, Yamaguchi Y, Okamura H (2017) Accelerating recovery from jet lag: prediction from a multioscillator model and its experimental confirmation in model animals. Sci Rep 7: 46702.
doi:10.1038/srep46702
92. Dojo K, Yamaguchi Y, Fustin JM, Doi M, Kobayashi M, Okamura H (2017) Carbachol Induces Phasedependent Phase Shifts of Per1 Transcription Rhythms in Cultured Suprachiasmatic Nucleus Slices. J. Biol.
Rhythms 32(2): 101-108. doi:10.1177/0748730417691205
93. Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang LD, Yoshida M, Miyazato M, Ichimura A,
Takeshima H (2017) Gm7325 is MyoD-dependently expressed in activated muscle satellite cells. Biomed.
Res. 38(3): 215-219. doi:10.2220/biomedres.38.215
94. Akamine Y, Sugawara-Kikuchi Y, Uno T, Shimizu T, Miura M (2017) Quantification of the steady-state
plasma concentrations of clozapine and N-desmethylclozapine in Japanese patients with schizophrenia
using a novel HPLC method and the effects of CYPs and ABC transporters polymorphisms. Ann. Clin.
Biochem. 54(6): 677-685. doi:10.1177/0004563216686377
95. Tanaka O, Maeda E, Fushimi M, Iwata T, Shimizu T, Saito S, Murata K (2017) Precarious Employment Is
Not Associated with Increased Depressive Symptoms: A Cross-Sectional Study in Care Service Workers ofJapan. Tohoku J. Exp. Med. 243(1): 19-26. doi:10.1620/tjem.243.19
96. Takeshima M, Ishikawa H, Shimizu T (2017) Acute Respiratory Distress Syndrome and Lamotrigine: A
Case Report. Psychosomatics 58(3):313-316. doi:10.1016/j.psym.2016.12.005
97. Kamigaki T, Dan Y (2017) Delay activity of specific prefrontal interneuron subtypes modulates memoryguided behavior. Nat. Neurosci. 20(6): 854-863. doi:10.1038/nn.4554
98. Minces V, Pinto L, Dan Y, Chiba AA (2017) Cholinergic shaping of neural correlations. Proc. Natl. Acad.
Sci. U.S.A. 114(22): 5725-5730. doi:10.1073/pnas.1621493114
99. Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hormann N, Chang WC, Zhang Z, Do JP, Ao
SY, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y (2017) Identification of preoptic sleep
neurons using retrograde labelling and gene profiling. Nature 545(7655): 477-481.
doi:10.1038/nature22350
100. Fontenot MR, Berto S, Liu YX, Werthmann G, Douglas C, Usui N, Gleason K, Tamminga, CA, Takahashi JS,
Konopka G (2017) Novel transcriptional networks regulated by CLOCK in human neurons. Genes Dev.
31(21): 2121-2135. doi:10.1101/gad.305813.117
101. Sun L, Jiang ZF, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang JH, Wang KW, Kilaru GK, Mohawk
JA, Quan JX, Scott L, Hildebrand S, Li XH, Tang M, Zhan XM, Murray AR, La Vine D, Moresco EMY,
Takahashi JS, Beutler B (2017) HCFC2 is needed for IRF1-and IRF2-dependent Tlr3 transcription and forsurvival during viral infections. J. Exp. Med. 214(11): 3263-3277. doi:10.1084/jem.20161630
102. Yoo SH, Kojima S, Shimomura K, Koike N, Buhr ED, Furukawa T, Ko CH, Gloston G, Ayoub C, Nohara K,
Reyes BA, Tsuchiya Y, Yoo OJ, Yagita K, Lee C, Chen Z, Yamazaki S, Green CB, Takahashi JS (2017)
Period2 3 '-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein
accumulation. Proc. Natl. Acad. Sci. U.S.A. 114(42): E8855-E8864. doi:10.1073/pnas.1706611114
103. Hughes ME, Abruzzi KC, Allada R, Anafi, R, Arpat, AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D,
Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L,
Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH,
Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel
H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N,
Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li JJ, Li XD, Liu AC, Loros JJ, Martino TA, Menet JS,

8
IIISFY2017

Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptacek LJ,
Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi
P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark
PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB (2017) Guidelines for
Genome-Scale Analysis of Biological Rhythms. J. Biol. Rhythms 32(5): 380-393.
doi:10.1177/0748730417728663
104. Rijo-Ferreira F, Takahashi JS, Figueiredo LM (2017) Circadian rhythms in parasites. PLoS Pathog. 13(10):e1006590. doi:10.1371/journal.ppat.1006590
105. Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA,
Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin
YX, Cowan CW (2017) HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens toRegulate Cocaine-Conditioned Behaviors. Neuron 96(1): 130-144.e6. doi:10.1016/j.neuron.2017.09.015
106. Wang H, van Spyk E, Liu Q, Geyfman M, Salmans ML, Kumar V, Ihler A, Li N, Takahashi JS, Andersen B(2017) Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. Cell
Reports 20(5): 1061-1072. doi:10.1016/j.celrep.2017.07.022
107. Ehlen JC, Brager AJ, Baggs J, Pinckney L, Gray CL, DeBruyne JP, Esser KA, Takahashi JS, Paul KN (2017)
Bmal1 function in skeletal muscle regulates sleep. eLife 6: e26557. doi:10.7554/eLife.26557
108. Acosta-Rodriguez VA, de Groot MHM, Rijo-Ferreira F, Green CB, Takahashi JS (2017) Mice under Caloric
Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder
System. Cell Metab. 26(1): 267-277.e2. doi:10.1016/j.cmet.2017.06.007
109. Rijo-Ferreira F, Pinto-Neves D, Barbosa-Morais NL, Takahashi JS, Figueiredo LM (2017) Trypanosoma
brucei metabolism is under circadian control. Nat. Microbiol. 2:17032. doi:10.1038/nmicrobiol.2017.32
110. Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM,
Takahashi JS, Partch CL (2017) Formation of a repressive complex in the mammalian circadian clock ismediated by the secondary pocket of CRY1. Proc. Natl. Acad. Sci. U.S.A. 114(7): 1560-1565.
doi:10.1073/pnas.1615310114
111. Verkooijen S, van Bergen AH, Knapen SE, Vreeker A, Abramovic L, Pagani L, Jung Y, Riemersma-van der
Lek R, Schoevers RA, Takahashi JS, Kahn RS, Boks MPM, Ophoff RA (2017) An actigraphy study
investigating sleep in bipolar I patients, unaffected siblings and controls. J. Affect. Disorders 208: 248254. doi:10.1016/j.jad.2016.08.076
112. Sinturel F, Gerber A, Mauvoisin D, Wang JK, Gatfield D, Stubblefield JJ, Green CB, Gachon F, Schibler U(2017) Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles. Cell
169(4): 651-663.e14. doi:10.1016/j.cell.2017.04.015
113. Ohtaki Y, Ohi YC, Suzuki S, Usami K, Sasahara S, Matsuzaki I (2017) Parental bonding during childhood
affects stress-coping ability and stress reaction. J. Health Psychol. 22(8): 1004-1011.
doi:10.1177/1359105315621780
114. Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y,
Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K,
Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N (2017) Effect of sodiumglucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose
neurocircuitry. Biochem. Biophys. Res. Commun. 493(1): 40-45. doi:10.1016/j.bbrc.2017.09.081
115. Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto
M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T (2017) Critical Role of CREBH-MediatedInduction of Transforming Growth Factor beta 2 by Hepatitis C Virus Infection in Fibrogenic Responses in
Hepatic Stellate Cells. Hepatology 66(5): 1430-1443. doi:10.1002/hep.29319

9
IIISFY2017116. Matsunaga S, Tanaka S, Fujihara K, Horikawa C, Iimuro S, Kitaoka M, Sato A, Nakamura J, Haneda M,
Shimano H, Akanuma Y, Ohashi Y, Sone H (2017) Association between all-cause mortality arid severity ofdepressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications
Study (JDCS). J. Psychosom Res. 99: 34-39. doi:10.1016/j.jpsychores.2017.05.020
117. Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O,
Sone H (2017) Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis. J. Diabetes.
Investig. 8(4): 501-509. doi:10.1111/jdi.12623
118. Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao XY,
Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y,
Kawakami Y, Kadowaki T, Yamada N, Shimano H (2017) A key role of nuclear factor Y in the refeeding
response of fatty acid synthase in adipocytes. FEBS Letters. 591(7): 965-978.
doi:10.1002/1873-3468.12620
119. Fujihara K, Igarashi R, Matsunaga S, Matsubayashi Y, Yamada T, Yokoyama H, Tanaka S, Shimano H,
Maegawa H, Yamazaki K, Kawai K, Sone H (2017) Comparison of baseline characteristics and clinicalcourse in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic
agents were chosen by diabetes specialists as initial monotherapy (JDDM 42). Medicine 96(7): e6122.
doi:10.1097/MD.0000000000006122
120. Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA,
Dickinson ME, Hadjantonakis AK (2017) Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic
Lethality and Defects in Early Mesodermal Derivatives. Cell Reports 20(9) :2116-2130.
doi:10.1016/j.celrep.2017.08.014
121. Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger
JM, Reversade B, Ito H, Imai Y, Kuba K (2017) ELABELA-APJ axis protects from pressure overload heart
failure and angiotensin II-induced cardiac damage. Cardiovasc. Res. 113(7): 760-769.
doi:10.1093/cvr/cvx061
122. Hirota K, Shigekawa C, Araoi S, Sha L, Inagawa T, Kanou A, Kako K, Daitoku H, Fukamizu A (2017)
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations
in Caenorhabditis elegans. J. Biochem. 161(6): 521-527. doi:10.1093/jb/mvw101
123. Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZS, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T,
Hozawa A, Karumanchi SA, Suzuki N, Yamamoto M (2017) Nrf2 inactivation enhances placental
angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Sci Signal10(479): eaam5711. doi:10.1126/scisignal.aam5711
124. Ishimaru T Ishida J, Kim JD, Mizukami H, Hara K, Hashimoto M, Yagami K, Sugiyama F, Fukamizu A(2017) Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells.
J. Biochem. 161(3): 255-258. doi:10.1093/jb/mvw095
125. Sha L, Daitoku H, Araoi S, Kaneko Y, Takahashi Y, Kako K, Fukamizu A (2017) Asymmetric Arginine
Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans.
Mol. Cell. Biol. 37(6): e00504-16. doi:10.1128/MCB.00504-16
126. Taniguchi H, Okamuro S, Koji M, Waku T, Kubo K, Hatanaka A, Sun YM, Chowdhury AMMA, Fukamizu A,
Kobayashi A (2017) Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis byregulating the gene expression of deubiquitinating enzymes. Biochem. Biophys. Res. Commun. 484(1):176-183. doi:10.1016/j.bbrc.2017.01.038
127. Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi JB, Fukamizu A, Sugiyama F, Takahashi S,
Yamamoto M (2017) Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative
Stress. Cell Reports 18(8): 2030-2044. doi:10.1016/j.celrep.2017.01.064

10
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FY2017128. Kawasaki S, Kako K, Nagashima Y, Kanou A, Ishida J, Fukamizu A (2017) Hydralazine is involved in telemethylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive
mice. J. Biochem. 161(2): 155-158. doi:10.1093/jb/mvw090
129. Kanou A, Kako K, Hirota K, Fukamizu A (2017) PRMT-5 converts monomethylarginines into symmetricaldimethylarginines in Caenorhabditis elegans. J. Biochem. 161(2): 231-235. doi:10.1093/jb/mvw066
130. Matsuda T, Hiyama TY, Niimura F, Matsusaka T, Fukamizu A, Kobayashi K, Kobayashi K, Noda M (2017)
Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ. Nat.
Neurosci. 20(2):230-241. doi:10.1038/nn.4463
131. Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, Okada R, Wakui H, Tsunakawa Y,
Watanabe H, Kimata K, Narimatsu H, Kudo T, Takahashi S (2017) Postnatal lethality andchondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and-2.
PLoS One 12(12): e0190333. doi:10.1371/journal.pone.0190333
132. Yang KM, Bae E, Ahn SG, Pang K, Park Y, Park J, Lee J, Ooshima A, Park B, Kim J, Jung Y, Takahashi S,
Jeong J, Park SH, Kim SJ (2017) Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B
in Triple-Negative Breast Cancer Cells. Cell Reports 21(10): 2952-2964. doi:10.1016/j.celrep.2017.11.026
133. Yu JS, Hamada M, Ohtsuka S, Yoh KY, Takahashi S, Miaw SC (2017) Differentiation of IL-17-Producing
Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf. Front Immunol 8:1399. doi:10.3389/fimmu.2017.01399
134. Okada T, Keino-Masu K, Nagamine S, Kametani F, Ohto T, Hasegawa M, van Kuppevelt TH, Kunita S,
Takahashi S, Masu M (2017) Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for
Corticospinal Tract Formation. Sci Rep 7(1): 13847. doi:10.1038/s41598-017-14185-3
135. Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y,
Takahashi S, Yagami K, Sugiyama F (2017) Simple generation of hairless mice for in vivo imaging. Exp.
Anim. 66(4): 437-445. doi:10.1538/expanim.17-0049
136. Dai SB, Mizuno H, Yumoto A, Shimomura M, Kobayashi H, Morita H, Shimbo M, Hamada M, Kudo T,
Shinohara, M, Asahara H, Shirakawa M, Takahashi S (2017) Development of new experimental platform'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on
mice. Sci Rep 7(1): 10837. doi:10.1038/s41598-017-10998-4
137. Sato F, Kawai E, Martinez NE, Omura S, Park AM, Takahashi S, Yoh K, Tsunoda I (2017) T-bet, but not
Gata3, overexpression is detrimental in a neurotropic viral infection. Sci Rep 7(1): 10496.
doi: 0.1038/s41598-017-10980-0
138. Morita H, Yamaguchi A, Shiba D, Shirakawa M, Takahashi S (2017) Impact of a simulated gravity load foratmospheric reentry, 10 g for 2 min, on conscious mice. J Physiol Sci. 67(4): 531-537.
doi:10.1007/s12576-017-0526-z
139. Ishikawa C, Li HY, Ogura R, Yoshimura Y, Kudo T, Shirakawa M, Shiba D, Takahashi S, Morita H, Shiga T(2017) Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mousebrain. PLoS One 12(6): e0177833. doi:10.1371/journal.pone.0177833
140. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T,
Yoshimura A (2017) MAFB prevents excess inflammation after ischemic stroke by accelerating clearanceof damage signals through MSR1. Nat. Med. 23(6): 723-732.doi:10.1038/nm.4312
141. Miura Y, Bich VNT, Furuya M, Hasegawa H, Takahashi S, Katagiri N, Hongu T, Funakoshi Y, Ohbayashi N,
Kanaho Y (2017) The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator forskin wound healing. Sci Rep 7: 46649. doi:10.1038/srep46649

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FY2017142. Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H,
Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi, S, Ueno N, Takahashi S, Takada S, Yoshida S(2017) SHISA6 Confers Resistance to Differentiation-Promoting Wnt/beta-Catenin Signaling in Mouse
Spermatogenic Stem Cells. Stem Cell Reports 8(3): 561-575. doi:10.1016/j.stemcr.2017.01.006
143. Koshida R, Oishi H, Hamada M, Takei Y, Takahashi S (2017) MafB is required for development of thehindbrain choroid plexus. Biochem. Biophys. Res. Commun. 483(1): 288-293.
doi:10.1016/j.bbrc.2016.12.150
144. Takahashi Y, Ha D, Oshima N, Yamada K, Abe T, Suzuki K (2017) Aerodecelerator Performance of FlareType Membrane Inflatable Vehicle in Suborbital Reentry. J Spacecr Rockets. 54(5): 993-1004
doi:10.2514/1.A33682
145. Matsumura E, Sekiya M, Omoto M, Santo K, Shikama A, Kuba M, Sugano Y, Iwasaki H, Yatou S, Sato T,
Hara H, Takekoshi K, Suzuki H, Shimano H (2017) A Rare Coexistence of Pheochromocytoma andParkinson's Disease With Diagnostic Challenges. Intern Med. 57(7): 979-985
doi:10.2169/internalmedicine.9242-17
146. Muranaka H, Hayashi A, Minami K, Kitajima S, Kohno S, Nishimoto Y, Nagatani N, Suzuki M, Kulathunga
LAN, Sasaki N, Okada N, Matsuzaka T, Shimano H, Tada H, Takahashi C (2017) A distinct function of theretinoblastoma protein in the control of lipid composition identified by lipidomic profiling. Oncogenesis.
6(6): e350. doi:10.1038/oncsis.2017.51
147. Yang K-M, Bae E-J, Ahn SK, Pang KW, Park Y, Park J, Lee J, Park B, Kwak M-K, Ooshima A, Kim J, Jung Y,
Takahashi S, Jeong J, Park SH, Kim S-J (2017) Co-chaperone BAG2 determines pro-oncogenic role of
Cathepsin B in triple-negative breast cancer cells. Cell Rep 21(10): 2952-2964.
doi:10.1016/j.celrep.2017.11.026
148. Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H,
Matsunaga S, Ogawa Y, Shimano H, Sone H (2017) Relationships among cardiorespiratory fitness,muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for andprevent ng the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano)
2. Pediatr Diabetes. doi:10.1111/pedi.12623(2) Review articles
149. Goto K, Doi M, Wang TY, Kunisue S, Murai I, Okamura H (2017) G-protein-coupled receptor

signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock. Endocr. J.
64(6): 571-579. doi:10.1507/endocrj.EJ17-0130

150. Takahashi JS (2017) Transcriptional architecture of the mammalian circadian clock. Nat. Rev. Genet.

18(3): 164-179. doi:10.1038/nrg.2016.150

151. Thompson MD, Sakurai T, Rainero I, Maj MC, Kukkonen JP (2017) Orexin Receptor Multimerization

versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid
Signalling and Pharmacogenetics. 10(4): 79. doi:10.3390/ph10040079.
152. Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K,

Hanyu O, Sone H (2018) Quantitative Relationship Between Cumulative Risk Alleles Based on
Genome-Wide Association Studies and Type 2 Diabetes Mellitus. J Epidemiol. 28(1): 3-18.
doi:10.2188/jea.JE20160151(3) Proceedings

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FY2017153. Iizuka M, Takahashi S, Matsumoto I, Sumida T, Yoshimura A (2017) TCR analysis of infiltrated CD4(+) T
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154. Kilduff TS, Dan Y (2017) Editorial overview: Neurobiology of sleep 2017. Curr. Opin. Neurobiol. 44: A1A3. doi:10.1016/j.conb.2017.05.020
155. Takahashi JS (2017) Enriching the Circadian Proteome. Cell Metab.25(1): 1-2.
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