III Precautions When Using the Applicator
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●To patients who are using OneCrinoneⓇOneCrinone® 90mg Vaginal Gel Instructions

Follow the instructions of your physician and apply the gel at the same time every day.
If you have forgotten to apply the gel, do so when at the time that you realize.
Note that you must not apply an amount of the gel more than that to be applied once daily.
Gel may build-up inside the vagina and may form a solid discharge.
This is not abnormal, however discuss this with your physician if you have any concerns.
Do not use with other transvaginal drugs. If applying other drugs, leave at last
6 hours before or after applying this drug.
If you drop the applicator on the floor before use, use a new one for hygiene
reasons.

OneCrinone is a progesterone gel for once daily vaginaladministration using a prefilled applicator.
● Carefully read through this User Guide before use, and follow the instructions provided.
● Store this guide where it can be accessed at any time.

● This drug has been prescribed for your personal use only. Do not give it to others or share it with others.

● Read through this document carefully, and check with your physician if you are unsure of how to use theapplicator or if you have concerns while using OneCrinone.

Store this drug between (1℃ to 30℃).
Store in a cool location if you are in an area where temperatures exceed 30℃ in summer.

●Names of Applicator Parts

Follow the instructions of your physician and discard of used applicators inaccordance with your municipal regulations. (Made of polyethylene)
Residues may be discharged when having a bath or washing while using this drug,
however is not a problem with dosage. Take care during washing or other activities,
as applying excess pressure to the abdominal region immediately after using the gel
may cause it to be pushed out.
Snap tab※ When using at high altitudes (exceeding 760 m): additional required preparation
The difference in air pressure may cause the gel to spurt out whensnapping off the snap tab, so the following preparations are required.

Gel (drug)

Tube
Plastic ball(Assists with discharging the gel. Remains
inside the applicator after use)

Seam line

Applicator end

Bulb portion(Filled with air. Squeezing this portion
creates air pressure to discharge the gel)

① After Step 1, use a needle or pin to prick open a pinhole in aroundthe center of the bulb portion. This eliminates the difference in airpressure inside and outside the applicator at high altitudes,
allowing the appropriate dosage to be applied.
② The same procedures are used for Step 2 to 5.

●Each OneCrinone comes in an individually sealed package.

③ In Step 6, squeeze the bulb portion while keeping your finger
covering the pinhole you opened there.

On the Patient Website, you can view how-to videos as well as a FAQ.
https://www.mbj-fertility-patients.jp/ja/home/onecrinone.html
Costs incurred for network streaming shall be covered by the customer

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Applicator

Sealed package

JP-CRI-00094
Created December 2022

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OneCrinone® 90mg Vaginal Gel Instructions

I
Step

１

Preparing the applicator before insertion※Refer to the back cover if using at altitudes exceeding 760 m.

II Insert the applicator (drug)
Step

4

Snap tab

Lying face up

Tear open the sealed package and take out
the applicator.
Do not snap oﬀ the snap tab yet.

Standing in half-crouchingposition

Sitting down

Get into a position that makes it easier
to insert into the vagina, such as
sitting in a chair, half-crouching or
lying face up.

Step

2

Hold the applicator along the seam line(the joint of the bulb portion) between yourthumb and index finger.

GelPlastic ball

Step

3

5

Shake it 3 or 4 times with a snap of thewrist so that the gel collects toward the tip of
the tube.

Hold the applicator end, and slowly
insert it to the vagina until just before
the seam line (the joint of the bulbportion).

Hold the applicator end and twist off the snap
tab until it is smoothly removed, and discard it.
Do not cut open with scissors.
Take care not to pull the snap tab oﬀ while twisting it.
[Cutting open with scissors or pulling oﬀ the snap
tab while twisting, it will make the cut surface
sharp and may cause internal injury inside thevagina. Avoid using the applicator if it is in this condition.]
If you have diﬃculty twisting oﬀ the snap tab, try again
until it is twisted oﬀ. If the snap tab still cannot be twistedoﬀ, use a diﬀerent applicator.
When doing so, do not squeeze the bulb portion or the gel may
leak before use. (A small amount of gel may be discharged,
but this is not a problem.)If you are worried about the amount of gel that leaks out
before application, discuss the matter with your physician.

2Step

Step

6

With the applicator inserted, squeeze
the bulb portion swiftly and firmly todischarge the gel.
After discharging, withdraw the applicatorwhile still squeezing the bulb portion.
A small amount of gel may remain inside the tube,
however this is not a problem as the required dosage
has been discharged.
If the applied gel leaks out immediately after
application, discuss the matter with your physician.
If you are worried about the amount of gel remaining
inside the tube, discuss the matter with your physician.

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