2019

List of Publications in 2019
WPI papers(1) Original Articles
1. Chang YH, Nishimura S, Oishi H, Kelly VP, Kuno A, Takahashi S (2019) TRMT2A is a novel cell cycle
regulator that suppresses cell proliferation. Biochem Biophys Res Commun 508(2): 410-415.
doi:10.1016/j.bbrc.2018.11.104
2.

Fujii S, Kaushik MK, Zhou XZ, Korkutata M, Lazarus M (2019) Acute social defeat stress increases sleep
in mice. Front Neurosci 13. doi:10.3389/fnins.2019.00322

3.

Fujimori K, Aritake K, Oishi Y, Nagata N, Maehara T, Lazarus M, Urade Y (2019) L-PGDS-produced
PGD(2) in premature, but not in mature, adipocytes increases obesity and insulin resistance. Sci Rep 9.
doi:10.1038/s41598-018-38453-y

4.

Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, et al. (2019) A new
mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of
glucose kinetics in the brain. Dis Model Mech 12(9). doi:10.1242/dmm.038828

5.

Hada K, Hirota K, Inanobe A, Kako K, Miyata M, Araoi S, Matsumoto M, Ohta R, et al. (2019)
Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonicdevelopment in Caenorhabditis elegans. J Biol Chem 294(9): 3091-3099.
doi:10.1074/jbc.RA118.004726

6.

Hori D, Oi Y, Ohtaki Y, Andrea CS, Takahashi T, Shiraki N, Ikeda T, Ikeda Y, et al. (2019) Association
between flourishing mental health and occupational stress among workers of Tsukuba Science City,
Japan: a cross-sectional study. Environ Health Prev 24(1). doi:10.1186/s12199-019-0823-7

7.

Hori D, Takao S, Kawachi I, Ohtaki Y, Andrea CS, Takahashi T, Shiraki N, Ikeda T, et al. (2019)
Relationship between workplace social capital and suicidal ideation in the past year among employees
in Japan: a cross-sectional study. BMC Public Health 19. doi:10.1186/s12889-019-7244-9

8.

Imanishi A, Kanbayashi T, Sagawa Y, Taniguchi T, Usumoto A, Yuge K, Kotorii N, Kinoshita T, et al.
(2019) Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination. Sleep
Biol Rhythms 17(2): 259-261. doi:10.1007/s41105-019-00210-7

9.

Kakizaki M, Tsuneoka Y, Takase K, Kim SJ, Choi J, Ikkyu A, Abe M, Sakimura K, Yanagisawa M, Funato
H (2019) Differential roles of each orexin receptor signaling in obesity. iScience 20: 1-13.
doi:10.1016/j.isci.2019.09.003

10. Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda
H, et al. (2019) Clec10a regulates mite-induced dermatitis. Sci Immunol 4(42).
doi:10.1126/sciimmunol.aax6908
11. Kawai H, Takaki M, Sakamoto S, Shibata T, Tsuchida A, Yoshimura B, Yada Y, Matsumoto N, et al.
(2019) Anti-NMDA-receptor antibody in initial diagnosis of mood disorder. Eur Neuropsychopharmacol
29(9): 1041-1050. doi:10.1016/j.euroneuro.2019.07.137
12. Kitamura S, Takahashi M, Mishima K (2019) Sleep problem but not chronotype is associated withretirement from shift work: a cross-sectional retrospective study. Sleep Biol Rhythms 17(3): 331-337.
doi:10.1007/s41105-019-00221-4
13. Kodani S, Soya S, Sakurai T (2019) Optogenetic manipulation of neural circuits during monitoring
sleep/wakefulness states in mice. J Vis Exp (148). doi:10.3791/58613
14. Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin RJ, Murakoshi N, Fujii S, et al. (2019) Enhancing
endogenous adenosine A(2A) receptor signaling induces slow-wave sleep without affecting body
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temperature and cardiovascular function. Neuropharmacology 144: 122-132.
doi:10.1016/j.neuropharm.2018.10.022
15. Kutsumura N, Inagaki M, Kiriseko A, Saito T (2019) Total synthesis of 3-epi-Juruenolide C. Chem
Pharm Bull 67(6): 594-598. doi:10.1248/cpb.c19-00209
16. Kutsumura N, Numata K, Mosaki S, Saito T (2019) Total synthesis of haplacutines B and C.
Heterocycles 99(1): 614-624. doi:10.3987/COM-18-S(F)7
17. Lu WZ, Kim JD, Tabara S, Kwon C, Mizukami H, Kimura K, Fukamizu A (2019) The N-terminal sequenceof murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.
Biochem Biophys Res Commun 514(4): 1185-1191. doi:10.1016/j.bbrc.2019.05.077
18. Matsubara T, Suzuki K, Kawasaki A, Miyamoto M, Okamura M, Kanbayashi T, Takekawa H, Nakamura
T, et al. (2019) Sudden onset of sleep caused by hypothalamic infarction: a case report. BMC Neurol
19(1). doi:10.1186/s12883-019-1414-3
19. Miyagawa T, Hida A, Shimada M, Uehara C, Nishino Y, Kadotani H, Uchiyama M, Ebisawa T, et al.
(2019) A missense variant in PER2 is associated with delayed sleep-wake phase disorder in a Japanese
population. J Hum Genet 64(12): 1219-1225. doi:10.1038/s10038-019-0665-6
20. Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, et al. (2019)
Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice. Proc
Natl Acad Sci U.S.A. 116(32): 16062-16067. doi:10.1073/pnas.1906774116
21. Mizukami H, Kim JD, Tabara S, Lu WZ, Kwon C, Nakashima M, Fukamizu A (2019) KDM5D-mediatedH3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts.
J Biochem 165(4): 335-342. doi:10.1093/jb/mvy106
22. Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M,
Wakai K (2019) Frequency of forest walking is not associated with prevalence of hypertension based oncross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study.
Nagoya J Med Sci 81(3): 489-500. doi:10.18999/nagjms.81.3.489
23. Nagano K, Kwon C, Ishida J, Hashimoto T, Kim JD, Kishikawa N, Murao M, Kimura K, et al. (2019)
Cooperative action of APJ and alpha 1A-adrenergic receptor in vascular smooth muscle cells induces
vasoconstriction. J Biochem 166(5): 383-392. doi:10.1093/jb/mvz071
24. Nakahara K, Naba K, Saitoh T, Sugai T, Obata R, Nishiyama S, Einaga Y, Yamamoto T (2019)
Electrochemical pinacol coupling of acetophenone using boron-doped diamond electrode.
ChemElectroChem 6(16): 4153-4157. doi:10.1002/celc.201900202
25. Ogata H, Kayaba M, Tanaka Y, Yajima K, Iwayama K, Ando A, Park I, Kiyono K, et al. (2019) Effect ofskipping breakfast for 6 days on energy metabolism and diurnal rhythm of blood glucose in young
healthy Japanese males. Am J Clin Nutr 110(1): 41-52. doi:10.1093/ajcn/nqy346
26. Ohtaki Y, Doki S, Kaneko H, Hirai Y, Oi Y, Sasahara S, Matsuzaki I (2019) Relationship between suicidal
ideation and family problems among young callers to the Japanese crisis hotline. PLoS One 14(7).
doi:10.1371/journal.pone.0220493
27. Ono H, Kanbayashi T, Imanishi A, Ayabe T, Sagawa Y, Tsutsui K, Ohmori Y, Takeshima M, Nishino S,
Shimizu T (2019) Clinical characteristics of symptomatic narcolepsy or hypersomnia: an analysis of 182
consecutive cases with neurological disorders associated with hypersomnolence. Sleep Biol Rhythms
17(1): 123-140. doi:10.1007/s41105-018-0186-2
28. Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y,
et al. (2019) Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in
4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Bioorg Med Chem Lett 29(18):
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2655-2658. doi:10.1016/j.bmcl.2019.07.039
29. Schutz B, Ruppert AL, Strobel O, Lazarus M, Urade Y, Buchler MW, Weihe E (2019) Distribution pattern
and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract.
Sci Rep 9. doi:10.1038/s41598-019-53997-3
30. Seol J, Fujii Y, Park I, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Okura T, et al. (2019) Distinct effectsof orexin receptor antagonist and GABA(A) agonist on sleep and physical/cognitive functions after
forced awakening. Proc Natl Acad Sci U.S.A. 116(48): 24353-24358. doi:10.1073/pnas.1907354116
31. Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang YN, Motomura K, Shimura T, et al.
(2019) Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders byactivating brown adipose tissue and improving liver metabolism. Sci Rep 9. doi:10.1038/s41598-01941631-1
32. Srinivasan S, Hosokawa T, Vergara P, Cherasse Y, Naoi T, Sakurai T, Sakaguchi M (2019) Miniaturized
microscope with flexible light source input for neuronal imaging and manipulation in freely behaving
animals. Biochem Biophys Res Commun 517(3): 520-524. doi:10.1016/j.bbrc.2019.07.082
33. Sugiyama A, Yamada M, Furuie H, Gotoh L, Saitoh A, Nagase H, Oka JI, Yamada M (2019) Systemic
administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear
memory in rats. J Pharmacol Sci 139(3): 174-179. doi:10.1016/j.jphs.2019.01.002
34. Takahashi T, Hori D, Ikeda T, Ikeda Y, Shiraki N, Andrea CS, Ohtaki Y, Doki S, et al. (2019) NonRegular Employment Status Is Associated with Psychological Distress among Young Researchers: A
Cross-Sectional Study in Tsukuba, Japan. Tohoku J Exp Med 249(1): 57-64. doi:10.1620/tjem.249.57
35. Tanimura J, Nakagawa H, Tanake T, Kikuchi A, Osada S, Tanaka Y, Tokuyama K, Takamura T (2019)
The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia. Endocr
J 66(7): 615-620. doi:10.1507/endocrj.EJ18-0542
36. Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui T, Kanai M, et al. (2019)
Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients. Exp
Anim 68(1): 103-111. doi:10.1538/expanim.18-0093
37. Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M(2019) Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus forvisualization of VEGFR3 expression in vascular and lymphatic endothelial cells. PLoS One 14(1).
doi:10.1371/journal.pone.0210060
38. Watanabe T, Miyajima M, Ohta K, Yoshida N, Omoya R, Fujiwara M, Suzuki Y, Murata I, et al. (2019)
Predicting postictal suppression in electroconvulsive therapy using analysis of heart rate variability. J
Affect Disord 246: 355-360. doi:10.1016/j.jad.2018.12.090
39. Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, Oishi H, Takahashi S (2019) MafB is
important for pancreatic β-cell maintenance under a MafA deficient condition. Mol Cell Biol 39(17).
doi:10.1128/MCB.00080-19
40. Yamabe M, Horie K, Shiokawa H, Funato H, Yanagisawa M, Kitagawa H (2019) MC-SleepNet: Largescale Sleep Stage Scoring in Mice by Deep Neural Networks. Sci Rep 9. doi:10.1038/s41598-01951269-8
41. Yamada D, Yanagisawa S, Yoshizawa K, Yanagita S, Oka JI, Nagase H, Saitoh A (2019) Selective
agonists of the delta-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning ofcontextual fear memory in mice. Neuropharmacology 160. doi:10.1016/j.neuropharm.2019.107792
42. Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y,
et al. (2019) Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 143

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hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707
derivatives lacking the 4,5-epoxy ring. Bioorg Med Chem 27(8): 1747-1758.
doi:10.1016/j.bmc.2019.03.010
43. Yasugaki S, Liu CY, Kashiwagi M, Kanuka M, Honda T, Miyata S, Yanagisawa M, Hayashi Y (2019)
Effects of 3 weeks of water immersion and restraint stress on sleep in mice. Front Neurosci 13.
doi:10.3389/fnins.2019.01072
44. Yata M, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y,
Yanagisawa M, Nagase H (2019) A novel rearrangement reaction of morphinan to arylmorphan
skeletons and the pharmacologies of arylmorphan derivatives. Heterocycles 99(1): 134-144.
doi:10.3987/COM-18-S(F)53
45. Zhang Y, Sugai T, Yamamoto T, Yamamoto N, Kutsumura N, Einaga Y, Nishiyama S, Saitoh T, Nagase
H (2019) Oxidative cleavage of the acyl-carbon bond in ohenylacetone with electrogenerated
superoxide anions. ChemElectroChem 6(16): 4194-4198. doi:10.1002/celc.201801308
46. Zhang Z, Liu WY, Diao YP, Xu W, Zhong YH, Zhang JY, Lazarus M, Liu YY, Qu WM, Huang AL (2019)
Superior colliculus GABAergic neurons are essential for acute dark induction of wakefulness in mice.
Curr Biol 29(4): 637-644. doi:10.1016/j.cub.2018.12.031
47. Zhou XZ, Oishi Y, Cherasse Y, Korkutata M, Fujii S, Lee CY, Lazarus M (2019) Extracellular adenosine
and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in
mice. Neurochem Int 124: 256-263. doi:10.1016/j.neuint.2019.01.020(2) Review Articles
48. Barton M, Yanagisawa M (2019) Endothelin: 30 years from discovery to therapy. Hypertension 74(6):1232-1265. doi:10.1161/HYPERTENSIONAHA.119.12105
49. Fifel K, Videnovic A (2019) Chronotherapies for Parkinson's disease. Prog Neurobiol 174: 16-27.
doi:10.1016/j.pneurobio.2019.01.002
50. Kako K, Kim JD, Fukamizu A (2019) Emerging impacts of biological methylation on genetic information.
J Biochem 165(1): 9-18. doi:10.1093/jb/mvy075
51. Koyanagi I, Akers KG, Vergara P, Srinivasan S, Sakurai T, Sakaguchi M (2019) Memory consolidation
during sleep and adult hippocampal neurogenesis. Neural Regen Res 14(1): 20-23. doi:10.4103/16735374.243695
52. Lazarus M, Oishi Y, Bjorness TE, Greene RW (2019) Gating and the need for sleep: dissociable effects
of adenosine A(1) and A(2A) receptors. Front Neurosci 13. doi:10.3389/fnins.2019.00740
53. Mhatre PH, Karthik C, Kadirvelu K, Divya KL, Venkatasalam EP, Srinivasan S, Ramkumar G, Saranya C,
Shanmuganathan R (2019) Plant growth promoting rhizobacteria (PGPR): A potential alternative toolfor nematodes bio-control. Biocatal Agric Biotechnol 17: 119-128. doi:10.1016/j.bcab.2018.11.009
54. Mizunoe Y, Kobayashi M, Tagawa R, Nakagawa Y, Shimano H, Higami Y (2019) Association between
lysosomal dysfunction and obesity-related pathology: a key knowledge to prevent metabolic syndrome.
Int J Mol Sci 20(15). doi:10.3390/ijms20153688
55. Takaesu Y, Utsumi T, Okajima I, Shimura A, Kotorii N, Kuriyama K, Yamashita H, Suzuki M, Watanabe
N, Mishima K (2019) Psychosocial intervention for discontinuing benzodiazepine hypnotics in patientswith chronic insomnia: A systematic review and meta-analysis. Sleep Med Rev 48.
doi:10.1016/j.smrv.2019.101214(3) Proceedings
56. Bjorness TE, Greene RW (2019) Conditional knockout of adenosine a1 receptors occludes sleep
deprivation-induced enhancement of conditioned place preference. Sleep 42.
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57. Imanishi A, Kanbayashi T, Omori Y, Kazuhisa Y, Tsutsui K, Ono T, Mishima K (2019) Patients with
developmental disorders (adhd and asd) accompany with hypersomnolence have normal orexin levels.
Sleep 42.
(4) Other English Articles
58. Fifel K (2019) Neuropathology of circadian alterations in Parkinson disease. JAMA Neurol 76(1): 115115. doi:10.1001/jamaneurol.2018.3755
59. Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin RJ, Murakoshi N, Fujii S, et al. (2019) Enhancing
endogenous adenosine A(2A) receptor signaling induces slow-wave sleep without affecting bodytemperature and cardiovascular function (vol 144, pg 122, 2019). Neuropharmacology 153: 153-153.
doi:10.1016/j.neuropharm.2019.04.027

WPI-related papers(1) Original articles
60. Beytebiere JR, Trott AJ, Greenwell B, Osborne CA, Vitet H, Spence J, Yoo SH, Chen Z, et al. (2019)
Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmicenhancer-enhancer interactions. Genes Dev 33: 294-309. doi:10.1101/gad.322198.118
61. Cedernaes J, Huang WY, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, et al.
(2019) Transcriptional basis for rhythmic control of hunger and metabolism within the AgRP neuron.
Cell Metab 29(5): 1078-1091. doi:10.1016/j.cmet.2019.01.023
62. de Groot MHM, Castorena CM, Cox KH, Kumar V, Mohawk JA, Ahmed NI, Takahashi JS (2019) A novel
mutation in Slc2a4 as a mouse model of fatigue. Genes Brain Behav 18(8). doi:10.1111/gbb.12578
63. Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, et al. (2019)Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and bodytemperature rhythmicity. Nat Commun 10. doi:10.1038/s41467-019-10532-2
64. Ghandour K, Ohkawa N, Fung CCA, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, et al.
(2019) Orchestrated ensemble activities constitute a hippocampal memory engram. Nat Commun 10.
doi:10.1038/s41467-019-10683-2
65. Hamada Y, Takata T, Kawakita R, Kobara H, Okada M, Tamiya T, Kanbayashi T, Touge T, Deguchi K,
Masaki T (2019) Orexin secretion abnormality involved in excessive somnolence in CNS lymphoma
without hypothalamic lesions. J Clin Neurosci 64: 6-7. doi:10.1016/j.jocn.2019.03.066
66. Kikuchi YS, Kanbayashi T, Shimizu T (2019) Relationship between clozapine-induced
electroencephalogram abnormalities and serum concentration of clozapine in Japanese patients withtreatment-resistant schizophrenia. Psychiatry Investig 16(4): 279-284. doi:10.30773/pi.2018.12.16
67. Kishi T, Ikuta T, Matsui Y, Inada K, Matsuda Y, Mishima K, Iwata N (2019) Effect of discontinuation v.
maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episodepsychosis: a meta-analysis. Psychol Med 49(5): 772-779. doi:10.1017/S0033291718001393
68. Le PT, Bornstein SA, Motyl KJ, Tian L, Stubblefield JJ, Hong HK, Takahashi JS, Green CB, Rosen CJ,
Guntur AR (2019) A novel mouse model overexpressing Nocturnin results in decreased fat mass inmale mice. J Cell Physiol 234: 20228-20239. doi:10.1002/jcp.28623
69. Mohawk JA, Cox KH, Sato M, Yoo SH, Yanagisawa M, Olson EN, Takahashi JS (2019) Neuronal
myocyte-specific enhancer factor 2d (mef2d) is required for normal circadian and sleep behavior inmice. J Neurosci 39(40): 7958-7967. doi:10.1523/JNEUROSCI.0411-19.2019

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70. Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Saber ZM, Wada N, Li EX, Piao XY, et al. (2019)
Glucocorticoid receptor suppresses gene expression of Rev-erb alpha (Nr1d1) through interaction with
the CLOCK complex. FEBS Lett 593(4): 423-432. doi:10.1002/1873-3468.13328
71. Nohara K, Mallampalli V, Nemkov T, Wirianto M, Yang J, Ye YQ, Sun YX, Han L, et al. (2019) Nobiletin
fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic
challenge. Nat Commun 10. doi:10.1038/s41467-019-11926-y
72. Onder Y, Laothamatas I, Berto S, Sewart K, Kilaru G, Bordieanu B, Stubblefield JJ, Konopka G, Mishra
P, Green CB (2019) The circadian protein nocturnin regulates metabolic adaptation in brown adipose
tissue. iScience 19: 83-92. doi: 10.1016/j.sici.2019.07.16
73. Osawa T, Fujihara K, Harada M, Yamamoto M, Ishizawa M, Suzuki H, Ishiguro H, Matsubayashi Y, et al.
(2019) Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes. DiabetesMetab Res Rev 35(3). doi:10.1002/dmrr.3120
74. Qin RJ, Murakoshi N, Xu DZ, Tajiri K, Feng D, Stujanna EN, Yonebayashi S, Nakagawa Y, et al. (2019)
Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic
tone in myocardial infarction mice. Physiol Rep 7(4). doi:10.14814/phy2.13972
75. Sasako T, Ohsugi M, Kubota N, Itoh S, Okazaki Y, Terai A, Kubota T, Yamashita S, et al. (2019)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun 10.
doi:10.1038/s41467-019-08591-6
76. Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, et al. (2019)
Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine
pulmonary fibrosis. JCI Insight 4(1). doi:10.1172/jci.insight.122163
77. Shimura S, Watari H, Komatsu M, Kuchibiro T, Fukuda S, Nishio H, Kita M, Kida K, et al. (2019)
Antimicrobial susceptibility surveillance of obligate anaerobic bacteria in the Kinki area. J InfectChemother 25(11): 837-844. doi:10.1016/j.jiac.2019.07.018
78. Tanimoto K, Matsuzaki H, Okamura E, Ushiki A, Fukamizu A, Engel JD (2019) Transvection-likeinterchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26
locus in mouse. PLoS One 14(2). doi:10.1371/journal.pone.0203099
79. Toda H, Williams JA, Gulledge M, Sehgal A (2019) A sleep-inducing gene, nemuri, links sleep andimmune function in Drosophila. Science 363(6426). doi:10.1126/science.aat1650
80. Yang SZ, Siepka SM, Cox KH, Kumar V, de Groot M, Chelliah Y, Chen J, Tu B, Takahashi JS (2019)
Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice.
Proc Natl Acad Sci USA 116(44): 22229-22236. doi:10.1073/pnas.1904485116
81. Yasuda K, Maki T, Takata M, Kimura K, Takahashi T, Kanbayashi T, Murase N, Ohtani R, Takahashi R,
Nakamura M (2019) Bilateral oculomotor nerve palsy in a case of anti-aquaporin-4 antibody-positive
neuromyelitis optica spectrum disorder. J Clin Neurosci 66: 271-272. doi:10.1016/j.jocn.2019.05.043
82. Yoshitane H, Asano Y, Sagami A, Sakai S, Suzuki Y, Okamura H, Iwasaki W, Ozaki H, Fukada Y (2019)
Functional D-box sequences reset the circadian clock and drive mRNA rhythms. Commun Biol 2.
doi:10.1038/s42003-019-0522-3
83. Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, et al.
(2019) Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon. Proc
Natl Acad Sci USA 116(39): 19449-19457. doi:10.1073/pnas.1907875116(2) Review articles
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84. Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, et al. (2019)
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol 15(9):519-539. doi:10.1038/s41582-019-0226-9
85. Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, etal. (2019) Medicine in the fourth dimension. Cell Metab 30(2): 238-250.
doi:10.1016/j.cmet.2019.06.019
86. Cox KH, Takahashi JS (2019) Circadian clock genes and the transcriptional architecture of the clock
mechanism. J Mol Endocrinol 63(4): R93-R102. doi:10.1530/JME-19-0153
87. Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Rasadi K, Amarenco P, Barter PJ, Ceska R, et al.
(2019) The selective peroxisome proliferator-activated receptor alpha modulator (SPPARM) paradigm:
conceptual framework and therapeutic potential: A consensus statement from the International
Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc
Diabetol 18. doi:10.1186/s12933-019-0864-7
88. Kishi T, Nomura I, Sakuma K, Kitajima T, Mishima K, Iwata N (2019) Melatonin receptor agonistsramelteon and melatonin-for bipolar disorder: a systematic review and meta-analysis of double-blind,randomized, placebo-controlled trials. Neuropsychiatr Dis Treat 15: 1479-1486.
doi:10.2147/NDT.S198899
89. Kishi T, Sakuma K, Nomura I, Matsuda Y, Mishima K, Iwata N (2019) Brexpiprazole as Adjunctive
Treatment for Major Depressive Disorder Following Treatment Failure With at Least One Antidepressantin the Current Episode: a Systematic Review and Meta-Analysis. Int J Neuropsychopharmacol 22(11):698-709. doi:10.1093/ijnp/pyz040
90. Rijo-Ferreira F, Takahashi JS (2019) Genomics of circadian rhythms in health and disease. Genome
Med 11(1). doi:10.1186/s13073-019-0704-0
91. Sakamoto S, Kawai H, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K, Mizuki Y, Takaki M, Yamada N(2019) Anti-N-methyl-D-aspartate receptor encephalitis in psychiatry. Acta Med Okayama 73(3): 189195.
(3) Proceedings
92. Cho K, Ushiki T, Ishiguro H, Katagiri T, Suwabe T, Hirai H, Nakagawa Y, Masuko M, et al. (2019)
SOCS3 Deficiency on a High-Fat Diet Accelerates Systemic Inflammation and Results in Lethal Myeloid
Hematopoiesis without Obesity and Adiposity. Diabetes 68. doi:10.2337/db19-1910-P
93. Czeisler ME, Shan YL, Schalek RL, Takahashi J, Lichtman J (2019) 3-D reconstruction of neurons
driving circadian rhythms. Sleep 42.
94. Ishihara A, Morita E, Matsumoto S, Suzuki C, Hiei T, Ikeda Y, Ishitsuka M, Hori D, et al. (2019)
Association between the evening use of electronic media, sleep, and chronotypes of employees inJapan. Neuropsychobiology 78(3): 164-164.
95. Nakagawa H, Yoshida S, Ohnishi A, Terada T, Funato H, Tsukamoto M (2019) Effect of using
smartphone during breast-feeding. UbiComp/ISWC '19 Adjunct: Adjunct Proc 2019 ACM Int Joint Conf
Pervasive and Ubiquit Comput and Proc 2019 ACM Int Symp Wearable Comput: 1190-1193.
doi:10.1145/3341162.3344840
96. Shigiyama F, Kumashiro N, Yoshikawa F, Tsuneoka Y, Funato H, Hirose T (2019) Mechanisms ofhepatic steatosis and insulin resistance induced by sleep deprivation in mice. Diabetes 68.
doi:10.2337/db18-1848-P
97. Wu A, Noel G, Wingate R, Kielstein H, Gill M, Sakurai T, Viranta-Kovanen S, Chien CL, et al. (2019)
Internationalization of medical education and the anatomy course - outcomes of an international
partnership of 11 anatomy departments in 4 continents. Faseb J 33.
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(4) Other English articles
98. Green CB (2019) Many paths to preserve the body clock. Science 363(6423): 124-125.
doi:10.1126/science.aav9706
99. Miyamoto T, Matsuzaka T, Shimano H (2019) Rho-associated, coiled-coil-containing protein kinase 1 asa new player in the regulation of hepatic lipogenesis. J Diabetes Investig 10(5): 1165-1167.
doi:10.1111/jdi.13051
100. Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M (2019) Sleep
and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in mice (vol 38, pg
10080, 2018). J Neurosci 39(11): 2157-2157.
101. Xu P, Cox KH, Takahashi JS (2019) A hyperkinetic redox sensor drives flies to sleep. Trends Neurosci
42(8): 514-517. doi:10.1016/j.tins.2019.05.007

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