IASMSAG
Metal Standard Aerosol Generation

IAS Inc.

MSAG is an indispensable tool for nano-particle analysis and direct gas analysis
such as laser ablation (LA) and Gas Exchange Device (GED) by ICP-MS.

Features◆ High precision syringe pump can introduce metal standard solution at a 1 μL/
min to a nebulizer and a 100% of solution is introduced to the plasma of ICPMS. As a result, the absolute amount of each element, e.g. ag/sec and atoms/
sec, introduced to the plasma can be calculated. As a result, analysis ofstandard nano-particle such as Au is not required.
◆ ICP-MS signal detected, e.g. counts/sec, from the standard solution above
gives the sensitivity of each element in ag/count.
◆ Transient signal analysis of ICP-MS can detects particles, which gives
absolute amount of each element in ag, which can calculate diameter of one
particle.
◆ Concentration of metallic impurities in gases in ng/kg or ng/m3 can becalculated as well as the particle size distribution of each element.
◆ Metal free structure for all contact parts with standard solution.

MSAG for nano particle analysis in solution.

Nano particle analysis in gas.

Calibration Curve by MSAG
●A 10 ng/mL mixed metal standard solution was directly introduced to a nebulizer from 0 to 3 μL/minby means of MSAG.

●MSGG (Metal Standard Gas Generation) unit was also used to monitor variation of ICP-MS
sensitivity, and Mo gaseous standard was used as an internal standard.

●

Linear calibration curves with internal standard correction were obtained below 3 μL/min.

●Three different nebulizer was checked with a 1 μL/min flow rate, and reproducible results wereobtained, which indicated that a 100% of standard solution introduced to the nebulizer was introduced
to the plasma of ICP-MS.
When the standard solution was introduced over 3 μL/min, the sensitivity started decreasing, whichindicated that some portion of standard solution was trapped in a spray chamber.
16000035000

140000Fe

140000120000Cu

Zn

120000

30000

100000

25000

80000

20000

80000

CountsCounts

100000

60000

15000

60000
40000

10000

20000

5000

40000
20000

0

0

00

2

0

4

2

uL/min450000042

51V
35,27836,07735,732
401
35,695
1.12

MSAG
208Pb
378,438391,145
393,8298,221
387,804
2.12

4uL/minuL/minNebulizer 1
Nebulizer 2
Nebulizer 3SD
Average
RSD (%)

238U
798,065
829,978
833,304
19,456820,449
2.37

52Cr
111,615
111,389
110,553559
111,186
0.50

MSGG
95Mo
182W
45,46088,48144,43588,35444,054
86,670727
1,011
44,65087,8351.63
1.15(Unit : count)

400000Fe ( 0 - 27 uL/min)

Mo gas

400000350000350000300000300000250000CountsCountsCounts●

250000200000200000150000150000100000100000

50000

50000

0001020uL/min

30

01020

uL/minCounts in Y axis is compensated intensity with Mo internal standard based on the count obtained at 1 uL/min uptake rate .

30

Metal particle analysis in NH3 gas by GED◆ Many particles of Cu and Zn were detected in a high purity NH3 gas by GED-ICP-MS.
◆ The concentration of Cu and Zn was calculated aqueous standard solution 0.48 and 0.07 ng/kg,respectively.
◆ One particle with 5 counts signal was equivalent to 30 and 36 nm particle size of pure Cu and Zn,respectively.
Ar blank

Ar blank

NH3NH3Specifications
Model： MSAG
Flow range ： 0.10～3.00 μL/min
Syringe： Glass 500 μL
Nebulizer： High efficiency concentric
Spray chamber： GlassIAS Inc.

Environment & Utilities
Room temperature ： 15～30℃
Humidity ： 35～85%RH no condensation
Power ： 100～240 VAC ±10% 2 A, Single
phase, 50/60 Hz
Size ： 166(W) x 295(D) x 630(H) mm
Weight ： 9 kg

IAS

2-2-1 Hinohonmachi, Hino, Tokyo, 191-0011 Japan
TEL: +81-42-589-5525
E-Mail: iasjapan@iasinc.jp URL: https://iasinc.jp

2022.04