2021

List of Publications in 2021
WPI papers(1) Original Articles
1. Suzuki Y, Kawana F, Satoh M, Abe T (2021) The abrupt shift to slower frequencies after arousal
from sleep in healthy young adults. Journal of Clinical Sleep Medicine 17(12): 2373-2381.
doi:10.5664/jcsm.9434
2.

Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato TA, Sakaguchi M (2021)
Metabolic fingerprints of fear memory consolidation during sleep. Molecular Brain 14(1).
doi:10.1186/s13041-021-00733-6

3.

Iwasaki K, Fujiyama T, Nakata S, Park M, Miyoshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M,
Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M (2021) Inductionof mutant Sik3(Sleepy) allele in neurons in late infancy increases sleep need. Journal of Neuroscience
41(12): 2733-2746. doi:10.1523/JNEUROSCI.1004-20.2020

4.

Choi J, Kim SJ, Fujiyama T, Miyoshi C, Park M, Suzuki-Abe H, Yanagisawa M, Funato H (2021) The
role of reproductive hormones in sex differences in sleep homeostasis and arousal response in mice.
Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.739236

5.

Kashiwagi M, Kanuka M, Tanaka K, Fujita M, Nakai A, Tatsuzawa C, Kobayashi K, Ikeda K, Hayashi
Y (2021) Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice. MolecularBrain 14(1). doi:10.1186/s13041-021-00879-3

6.

Gao TX, Li JY, Watanabe Y, Hung CJ, Yamanaka A, Horie K, Yanagisawa M, Ohsawa M, Kume K(2021) GI-SleepNet: A highly versatile image-based sleep classification using a deep learningalgorithm. Clocks & Sleep 3(4): 581-597. doi:10.3390/clockssleep3040041

7.

Zhang SM, Tanaka Y, Ishihara A, Uchizawa A, Park I, Iwayama K, Ogata H, Yajima K, Omi N, Satoh
M, Yanagisawa M, Sagayama H, Tokuyama K (2021) Metabolic flexibility during sleep. Scientific
Reports 11(1). doi:10.1038/s41598-021-97301-8

8.

Uchida S, Soya S, Saito YC, Hirano A, Koga K, Tsuda M, Abe M, Sakimura K, Sakurai T (2021) A
discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia
during REM sleep and cataplexy in mice. Journal of Neuroscience 41(7): 1582-1596.
doi:10.1523/JNEUROSCI.0688-20.2020

9.

Tezuka T, Kumar D, Singh S, Koyanagi I, Naoi T, Sakaguchi M (2021) Real-time, automatic, opensource sleep stage classification system using single EEG for mice. Scientific Reports 11(1).
doi:10.1038/s41598-021-90332-1

10. Liu CY, Tsai CJ, Yasugaki S, Nagata N, Morita M, Isotani A, Yanagisawa M, Hayashi Y (2021) Copine7 is required for REM sleep regulation following cage change or water immersion and restraint stressin mice. Neuroscience Research 14-25. doi:10.1016/j.neures.2020.04.002
11. Park I, Diaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh
M, Tokuyama K, Vogt KE (2021) Exercise improves the quality of slow-wave sleep by increasingslow-wave stability. Scientific reports 11(1). doi:10.1038/s41598-021-83817-6
12. Kaushik MK, Aritake K, Cherasse Y, Imanishi A, Kanbayashi T, Urade Y, Yanagisawa M (2021)
Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice. Sleep 44(8).
doi:10.1093/sleep/zsab043
13. Uchizawa A, Hibi M, Sagayama H, Zhang SM, Osumi H, Tanaka Y, Park I, Tokuyama K, Omi N (2021)
Novel equations to estimate resting energy expenditure during sitting and sleeping. Annals of
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Nutrition and Metabolism 77(3): 159-167. doi:10.1159/000516174
14. Seol J, Park I, Kokudo C, Zhang SM, Suzuki C, Yajima K, Satoh M, Tokuyama K, Okura T (2021)
Distinct effects of low-intensity physical activity in the evening on sleep quality in older women: A
comparisonofexerciseandhousework.
Experimental
Gerontology
143.
doi:10.1016/j.exger.2020.111165
15. Suzuki F, Morita E, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K,
Kannon T, Tajima A, Matsumoto S, Ishihara A, Hori D, Doki S, Oi Y, Sasahara S, Satoh M, Matsuzaki
I, Yanagisawa M, Ikaga T, Nakamura H (2021) Protein intake in inhabitants with regular exercise isassociated with sleep quality: Results of the Shika study. PLOS ONE 16(2).
doi:10.1371/journal.pone.0247926
16. Seol J, Lee J, Nagata K, Fujii Y, Joho K, Tateoka K, Inoue T, Liu J, Okura T (2021) Combined effectof daily physical activity and social relationships on sleep disorder among older adults: crosssectional and longitudinal study based on data from the Kasama study. BMC Geriatrics 21(1).
doi:10.1186/s12877-021-02589-w
17. Yang YF, Dong H, Shen Y, Li L, Lazarus M, Qu WM, Huang ZL (2021) Mesencephalic dopamine
neurons are essential for modafinil-induced arousal. British Journal of Pharmacology 178(24): 48084825. doi:10.1111/bph.15660
18. Tanida K, Shimada M, Khor SS, Toyoda H, Kato K, Kotorii N, Kotorii T, Ariyoshi Y, Kato T, Hiejima H,
Ozone M, Uchimura N, Ikegami A, Kume K, Kanbayashi T, Imanishi A, Kamei Y, Hida A, Wada Y,
Kuroda K, Miyamoto M, Hirata K, Takami M, Yamada N, Okawa M, Omata N, Kondo H, Kodama T,
Inoue Y, Mishima K, Honda M, Tokunaga K, Miyagawa T (2022) Genome-wide association study of
idiopathic hypersomnia in a Japanese population. Sleep and Biological Rhythms 20(1): 137-148.
doi:10.1007/s41105-021-00349-2
19. Kaneko Y, Inoue Y, Fujiki N, Han G, Nishino S, Shimizu T, Kanbayashi T, Kondo H (2021) The
anticataplectic and REM suppression effect of milnacipran, an SNRI, on human and canine narcolepsy.
Sleep and Biological Rhythms 19(2): 137-143. doi:10.1007/s41105-020-00298-2
20. Ishihara A, Park I, Suzuki Y, Yajima K, Cui H, Yanagisawa M, Sano T, Kido J, Tokuyama K (2021)
Metabolic responses to polychromatic LED and OLED light at night. Scientific reports 11(1).
doi:10.1038/s41598-021-91828-6
21. Saito R, Miyoshi C, Koebis M, Kushima I, Nakao K, Mori D, Ozaki N, Funato H, Yanagisawa M, Aiba
A (2021) Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed
the contribution of each deleted region to psychiatric disorders. Molecular Brain 14(1).
doi:10.1186/s13041-021-00778-7
22. Choi YJ, Nakamura Y, Akazawa N, Park I, Kwak HB, Tokuyama K, Maeda S (2022) Effects of nocturnal
light exposure on circadian rhythm and energy metabolism in healthy adults: A randomized crossover
trial. Chronobiology International 39(4): 602-612. doi:10.1080/07420528.2021.2014517
23. Vergara P, Kumar D, Srinivasan S, Koyanagi I, Naoi T, Singh S, Sakaguchi M (2021) Remapping ofadult-born neuron activity during fear memory consolidation in mice. International Journal of
Molecular Sciences 22(6). doi:10.3390/ijms22062874
24. Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL (2021)
Medial parabrachial nucleus is essential in controlling wakefulness in rats. Frontiers in Neuroscience
15. doi:10.3389/fnins.2021.645877
25. Inagawa Y, Shimizu S, Takenoshita n, Tsugawa A, Hirose D, Kanbayashi T, Imanishi A, Sakurai H,
Hanyu H, Kanetaka H, Hirao K (2021) Association between cerebrospinal fluid Orexin A level andseverity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies.
Psychogeriatrics 21(1): 128-130. doi:10.1111/psyg.12618
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26. Li YD, Luo YJ, Xu W, Ge J, Cherasse Y, Wang YQ, Lazarus M, Qu WM, Huang ZL (2021) Ventral
pallidal GABAergic neurons control wakefulness associated with motivation through the ventral
tegmental pathway. Molecular Psychiatry 26(7): 2912-2928. doi:10.1038/s41380-020-00906-0
27. Miyanishi K, Sato A, Kihara N, Utsunomiya R, Tanaka J (2021) Synaptic elimination by microglia anddisturbed
higherbrain
functions.
Neurochemistry
International142.
doi:10.1016/j.neuint.2020.104901
28. Yu JH, Naoi T, Sakaguchi M (2021) Fear generalization immediately after contextual fear memory
consolidation in mice. Biochemical and Biophysical Research Communications 102-106.
doi:10.1016/j.bbrc.2021.04.072
29. Tanaka Y, Ogata H, Park I, Ando A, Ishihara A, Kayaba M, Yajima K, Suzuki C, Araki A, Osumi H,
Zhang SM, Seol J, Takahashi K, Nabekura Y, Satoh M, Tokuyama K (2021) Effect of a single bout ofmorning or afternoon exercise on glucose fluctuation in young healthy men. Physiological Reports
9(7). doi:10.14814/phy2.14784
30. Liu C, Lee CY, Asher G, Cao LQ, Terakoshi Y, Cao P, Kobayakawa R, Kobayakawa K, Sakurai K, Liu
QH (2021) Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia inmice. Nature Communications 12(1). doi:10.1038/s41467-021-22914-6
31. Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii KA, Tanaka T,
Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T (2022) Effects of eicosapentaenoic
acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans withdyslipidemia and type 2 diabetes. Journal of Diabetes Investigation 13(3): 532-542.
doi:10.1111/jdi.13699
32. Yamamoto T, Saitoh T, Einaga Y, Nishiyama S (2021) Anodic oxidation of phenols: A key step forthe synthesis of natural products. Chemical Record 21(9): 2254-2268. doi:10.1002/tcr.202100032
33. Noorani SK, Hojati V, Akbari E, Ehsani S, Sakurai T, Ardeshiri MR (2021) The role of interaction
between orexin receptors and beta 2 adrenergic receptors in basolateral amygdala in dentate gyrus
synaptic
plasticity
in
male
rats.
Brain
Research
Bulletin164-171.
doi:10.1016/j.brainresbull.2021.09.020
34. Maejima T, Tsuno Y, Miyazaki S, Tsuneoka Y, Hasegawa E, Islam MT, Enoki R, Nakamura TJ, Mieda
M (2021) GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus
molecular clocks enable circadian behavior. PNAS 118(6). doi:10.1073/pnas.2010168118
35. Yamada D, Takahashi J, Iio K, Nagase H, Saitoh A (2021) Modulation of glutamatergic synaptictransmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid
receptors in mice. Biochemical and Biophysical Research Communications 192-198.
doi:10.1016/j.bbrc.2021.05.002
36. Bittar TP, Pelaez MC, Silva JCH, Quessy F, Lavigne AA, Morency D, Blanchette LJ, Arsenault E,
Cherasse Y, Seigneur J, Timofeev I, Sephton CF, Proulx CD, Labonte B (2021) Chronic stress induces
sex-specific functional and morphological alterations in corticoaccumbal and corticotegmental
pathways. Biological Psychiatry 90(3): 194-205. doi:10.1016/j.biopsych.2021.02.014
37. Sakamoto K, Yamada D, Yamanaka N, Nishida M, Iio K, Nagase H, Saitoh A (2021) A selective delta
opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal
glutamatergic system in mice. Brain Research 1757. doi:10.1016/j.brainres.2021.147297
38. Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary
E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N,
Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume
K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM,
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Dauvilliers Y, Arnulf I, Mignot EJM (2021) Kleine-Levin syndrome is associated with birth difficulties
and genetic variants in the TRANK1 gene loci. PNAS 118(12). doi:10.1073/pnas.2005753118
39. Matsuo T, Isosaka T, Hayashi Y, Tang LJ, Doi A, Yasuda A, Hayashi M, Lee CY, Cao LQ, Kutsuna N,
Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu QH, Kobayakawa R,
Kobayakawa K (2021) Thiazoline-related innate fear stimuli orchestrate hypothermia and antihypoxia via sensory TRPA1 activation. Nature Communications 12(1). doi:10.1038/s41467-02122205-0
40. Nagata K, Nagase H, Okuzumi A, Nishiyama C (2021) Delta opioid receptor agonists amelioratecolonic inflammation by modulating immune responses. Frontiers in Immunology 12.
doi:10.3389/fimmu.2021.730706
41. Ohrui S, Irukayama-Tomobe Y, Ishikawa Y, Yanagisawa M, Nagase H (2021) Design and synthesisof novel orexin antagonists via structural simplification of the morphinan skeleton. Heterocycles
103(2): 929-951. doi:10.3987/COM-20-S(K)63
42. Hino T, Kutsumura N, Saitoh T, Yamamoto N, Nagumo Y, Mogi Y, Watanabe Y, Nagase H (2021)
Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives. Tetrahedron Letters 63.
doi:10.1016/j.tetlet.2020.152714
43. Yu LY, Tseng TJ, Lin HC, Hsu CL, Lu TX, Tsai CJ, Lin YC, Chu I, Peng CT, Chen HJ, Tsai FC (2021)
Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration.
Science Advances 7(31). doi:10.1126/sciadv.abg2106
44. Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi
T, Tanaka K, Yamada N (2022) Impairment of early neuronal maturation in anti-NMDA-receptor
encephalitis. Psychopharmacology 239(2): 525-531. doi:10.1007/s00213-021-06036-x
45. Nakagawa Y, Wang YN, Han S, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe
Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano
H (2021) Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive
inhibition. Cellular and Molecular Gastroenterology and Hepatology 11(4): 949-971.
doi:10.1016/j.jcmgh.2020.11.004
46. Mizunoe Y, Kobayashi M, Saito H, Goto A, Migitaka R, Miura K, Okita N, Sudo Y, Tagawa R, Yoshida
M, Umemori A, Nakagawa Y, Shimano H, Higami Y (2021) Prolonged caloric restriction ameliorates
age-related atrophy in slow and fast muscle fibers of rat soleus muscle. Experimental gerontology
154. doi:10.1016/j.exger.2021.111519
47. Ryanto GRT, Ikeda K, Miyagawa K, Tu L, Guignabert C, Humbert M, Fujiyama T, Yanagisawa M,
Hirata K, Emoto N (2021) An endothelial activin A-bone morphogenetic protein receptor type 2 linkis overdriven in pulmonary hypertension. Nature communications 12(1). doi:10.1038/s41467-02121961-3
48. Shimamoto S, Nakagawa Y, Hidaka Y, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, Ohkubo T,
Aritake K, Kaushik MK, Urade Y (2021) Substrate-induced product-release mechanism of lipocalintype prostaglandin D synthase. Biochemical and biophysical research communications 66-71.
doi:10.1016/j.bbrc.2021.06.092
49. Omoya R, Miyajima M, Ohta K, Suzuki Y, Aoki A, Fujiwara M, Watanabe T, Yoshida N, Suwa H,
Kawara T, Takahashi H, Matsushima E, Takeuchi T (2021) Heart rate response to orthostaticchallenge in patients with dementia with Lewy bodies and Alzheimer's disease. Psychogeriatrics
21(1): 62-70. doi:10.1111/psyg.12625
50. Murata K, Mimura A, Suzuki H, Mikami N, Hamada Y, Kato K, Iki N, Ishida M, Daitoku Y, Tanimoto
Y, Okiyoneda T, Fujiyama T, Dinh TTH, Mizuno S, Sugiyama F (2021) Efficient induction of proximitydependent labelling by biotin feeding in BMAL1-BioID knock-in mice. Journal of Biochemistry 170(4):University of Tsukuba -4

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453-461. doi:10.1093/jb/mvab059
51. Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim
JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H (2021)
Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH
signaling. FASEB Journal 35(6). doi:10.1096/fj.202002784RR
52. Shokirova H, Inomata T, Saitoh T, Zhu J, Fujio K, Okumura Y, Yanagawa A, Fujimoto K, Sung J,
Eguchi A, Miura M, Nagino K, Hirosawa K, Kuwahara M, Akasaki Y, Nagase H, Murakami A (2021)
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal
neovascularization and inflammation. Scientific Reports 11(1). doi:10.1038/s41598-021-88118-6
53. Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan
ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S,
Yagami K, Wilson V, Arkell RM, Sugiyama F (2021) Disruption of entire Cables2 locus leads toembryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Elife 10.
doi:10.7554/eLife.50346
54. Takei Y, Hirai R, Fukuda A, Miyazaki S, Shimada R, Okamatsu-Ogura Y, Saito M, Leproux P, Hisatake
K, Kano H (2021) Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse
ultra-multiplex CARS microspectroscopy with an onstage incubator. Journal of Chemical Physics
155(12). doi:10.1063/5.0063250
55. Aso T, Amagasa T, Kitagawa H (2021) A system for relation-oriented faceted search over knowledge
bases. International Journal of Web Information Systems 17(6) 698-713. doi:10.1108/IJWIS-032021-0035
56. Takagi H, Chen H, Furuse K, Kitagawa H (2021) Aggregate nearest neighborhood queries. Proc.
FICC 2021. Advances in Intelligent Systems and Computing 1364 396–414. doi:10.1007/978-3-03073103-8_28
57. Kato Y, Chen H, Furuse K, Kitagawa H (2021) Unifying spatial keyword indexing in continuous searchon dynamic objects. Proc. FICC 2021. Advances in Intelligent Systems and Computing 1364 415–
430. doi:10.1007/978-3-030-73103-8_29
58. Khalique V, Kitagawa H (2021) VOA*: Fast angle-based outlier detection over high-dimensional data
streams. Proc. PAKDD 2021. Lecture Notes in Computer Science 12712 44-52. doi:10.1007/978-3030-75762-5_4
59. Yoshimura C, Kitagawa H (2021) TLV-Bandit: Bandit method for collecting topic-related local tweets.
Proc. 2021. IEEE 4th International Conference on Multimedia Information Processing and Retrieval(MIPR) 56-62. doi:1109/MIPR51284.2021.00016
60. Yamada M, Kitagawa H, Amagasa T, Matono A (2021) Augmented lineage: Traceability of data
analysis including complex UDFs. Proc. DEXA 2021. Lecture Notes in Computer Science 12923 65–
77. doi:10.1007/978-3-030-86472-9_6
61. Aso T, Amagasa T, Kitagawa H (2021) A method for searching documents using knowledge bases.
Proc. iiWAS2021 250-258. doi:10.1145/3487664.3487699
62. Carrier-Ruiz A, Sugaya Y, Kumar D, Vergara P, Koyanagi I, Srinivasan S, Naoi T, Kano M, Sakaguchi
M (2021) Calcium imaging of adult-born neurons in freely moving mice, STAR Protocols 2(1):100328,
2021Mar19. doi/10.1016/j.xpro.2020.100238
63. Tsai CJ, Nagata T, Liu CY, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M,
Vogt V, Yanagisawa M, Hayashi Y (2021) Cerebral capillary blood flow upsurge during REM sleep ismediated by A2a receptors. Cell Reports 36(7). doi:10.1016/j.celrep.2021.109558
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64. Sakamoto K, Morikuni K, Sakurai T, Matsumoto S, Vogt K (2021) Online spectral classification for
long-term spike sorting. 2021 5th International Conference on Medical and Health Informatics Pages
89-97
65. Park I, Díaz J, Matsumoto S, Iwayama K, Nabekura Y, Ogata H, Kayaba M, Aoyagi A, Yajima K, Satoh
M, Tokuyama K, Vogt K (2021) Exercise improves the quality of slow-wave sleep by increasing slowwave stability. Scientific Reports 11(1). doi:10.1038/s41598-021-83817-6
66. Park I, Suzuki C, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Kokubo T, Tokuyama K, Yanagisawa
M, Satoh M (2021) Effects of body pillow use on sleeping posture and sleep architecture in healthy
young adults. Sleep Medicine Research 12(1): 57-63.
67. Ikeda T, Hori D, Arai Y, Muroi K, Ikeda Y, Takahashi K, Shiraki N, Doki S, Oi Y, Sasahara S, Morita
E, Matsuzaki I (2021) Association between forest and greenspace walking and stress-coping skills
among workers of Tsukuba Science City, Japan: a cross-sectional study. Public Health in Practice.
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68. Sakurai T, Saito Y, Yanagisawa M (2021) Interaction between orexin neuronsand monoaminergic
systems. Front Neurol Neurosci 45 11-21. doi:10.1159/000514955
69. Suzuki Y, Abe T, Kawana F, Okabe S, Kokubo T, Hoshino K, Baba M, Fujiyama M, Yanagisawa M(2021) O-EG004.Comparing the accuracy of sleep staging data from a new wearable sleep
electroencephalography device versus the Fitbit Charge 3 with polysomnography as reference.
Clinical Neurophysiology 132(8): 67. doi:10.1016/j.clinph.2021.02.125
70. Suzuki-Abe H, Sonomura K, Nakata S, Miyanishi K, Mahmoud A, Hotta-Hirashima N, Miyoshi C, Sato
T, Funato H, Yanagisawa M (2021) Metabolomic and pharmacologic analyses of brain substances
associated with sleep pressure in mice. Journal of Neuroscience Research 177 16-24.
doi:10.1016/j.neures.2021.11.008
71. Iwasaki K, Hotta-Hirashima N, Funato H, Yanagisawa M (2021) Protocol for sleep analysis in thebrain of genetically modified adult mice. STAR Protocols 2(4): 100982. doi:
10.106/j.xpro.2021.100982
72. Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H (2021)
Spectroscopic second and third harmonic generation microscopy using a femtosecond laser sourcein the third near-infrared (NIR-III) optical window. Biomedical Optics Express 13(2): 694-708. doi:
10.1364/BOE.446273
73. Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H(2021) Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondria
disease. Cell Metabolism 33:1974-1987(2) Review articles
1. Fifel K, Videnovic A (2021) Circadian and sleep dysfunctions in neurodegenerative disorders-an
update. Frontiers in Neuroscience 14. doi:10.3389/fnins.2020.627330
2.

Bjorness ET, Greene WR (2021) Interaction between cocaine use and sleep behavior: A
comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions
influenceon
rewardseeking.
Pharmacology Biochemistry and Behavior 206.
doi:10.1016/j.pbb.2021.173194

3.

Tsuneoka Y, Funato H (2021) Cellular composition of the preoptic area regulating sleep, parental,
and sexual behavior. Frontiers in Neuroscience 15. doi:10.3389/fnins.2021.649159

4.

Choudhury ME, Miyanishi K, Takeda H, Tanaka J (2021) Microglia and the aging brain: Are geriatricmicroglia linked to poor sleep quality?. International Journal of Molecular Sciences 22(15).
doi:10.3390/ijms22157824
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5.

Yoshida S, Funato H (2021) Physical contact in parent-infant relationship and its effect on fostering
a feeling of safety. Iscience 24(7). doi:10.1016/j.isci.2021.102721

6.

Kikuchi JK, Nagashima Y, Mano T, Ishiura H, Hayashi T, Shimizu J, Matsukawa T, Ichikawa Y,
Takahashi Y, Karino S, Kanbayashi T, Kira J, Goto J, Tsuji S (2021) Cerebellar ataxia as a common
clinical presentation associated with DNMT1 p.Y511H and a review of the literature. Journal of
Molecular Neuroscience 71(9): 1796-1801. doi:10.1007/s12031-020-01784-5

7.

Nakagawa Y, Araki M, Han SI, Mizunoe Y, Shimano H (2021) CREBH systemically regulates lipid
metabolism
bymodulating
andintegrating
cellularfunctions.
Nutrients 13(9).
doi:10.3390/nu13093204

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Shibata T, Kawai H, Sakamoto S, Tsutsui K, Kanbayashi T, Tanaka K, Takaki M (2021) Rituximab
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17. Imanishi A, Omori Y, Ishido H, Sagawa Y, Han G, Mishima K, Kanbayashi T, Kondo H (2021)
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NMDA receptor encephalitis: A review of literature in the mid-twentieth century. Psychiatry andClinical Neurosciences 76(2): 62-63. doi:10.1111/pcn.13317
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21. Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y,
Mishima K (2021) The Role of the thalamus in the neurological mechanism of subjective sleepiness:
An fMRI study. Nature and Science of Sleep 899-921. doi:10.2147/NSS.S297309
22. Doki S, Sasahara S, Hori D, Oi Y, Takahashi T, Shiraki N, Ikeda Y, Ikeda T, Arai Y, Muroi K, Matsuzaki
I (2021) Comparison of predicted psychological distress among workers between artificial intelligenceand psychiatrists: a cross-sectional study in Tsukuba Science City, Japan. BMJ Open 11(6).
doi:10.1136/bmjopen-2020-046265
23. Shiraki N, Doki S, Ikeda Y, Ikeda T, Takahashi T, Andrea CS, Hori D, Oi Y, Sasahara S, Matsuzaki I(2021) Differences in psychological distress between managers and non-managers in female
workers: a cross-sectional study in Tsukuba Science City, Japan. Nagoya Journal of Medical Science83(1): 63-74. doi:10.18999/nagjms.83.1.63
24. Inada K, Enomoto M, Yamato K, Marumoto T, Takeshima M, Mishima K (2021) Effect of residual
insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a healthinsurance claims database. Journal of Affective Disorders 539-546. doi:10.1016/j.jad.2020.12.040
25. Motomura Y, Katsunuma R, Ayabe N, Oba K, Terasawa Y, Kitamura S, Moriguchi Y, Hida A, Kamei
Y, Mishima K (2021) Decreased activity in the reward network of chronic insomnia patients. Scientific
Reports 11(1). doi:10.1038/s41598-020-79989-2
26. Ishizuya A, Enomoto M, Tachimori H, Takahashi H, Sugihara G, Kitamura S, Mishima K (2021) Risk
factors for low adherence to methylphenidate treatment in pediatric patients with attentiondeficit/hyperactivity disorder. Scientific Reports 11(1). Doi:10.1038/s41598-021-81416-z
27. Narisawa H, Inoue Y, Kobayashi M, Okajima I, Kikuchi T, Kagimura T, Matsui K, Inada K, Mishima K(2021) Development and validation of the Benzodiazepine Hypnotics Withdrawal Symptom Scale(BHWSS)
based
on
item
response
theory.
Psychiatry
Research300.
doi:10.1016/j.psychres.2021.113900
28. Jeon H, Asano K, Wakimoto A, Kulathunga K, Tran MTN, Nakamura M, Yokomizo T, Hamada M,
Takahashi S (2021) Generation of reconstituted hemato-lymphoid murine embryos by placental
transplantation into embryos lacking HSCs. Scientific Reports 11(1). doi:10.1038/s41598-02183652-9
29. Daitoku H, Someya M, Kako K, Hayashi T, Tajima T, Haruki H, Sekiguchi N, Uetake T, Akimoto Y,
Fukamizu A (2021) siRNA screening identifies METTL9 as a histidine N pi-methyltransferase thattargets the proinflammatory protein S100A9. Journal of Biological Chemistry 297(5).
doi:10.1016/j.jbc.2021.101230
30. Inada K, Enomoto M, Yamato K, Mishima K (2021) Prescribing pattern of hypnotic medications inpatients initiating treatment at Japanese hospitals: A nationwide, retrospective, longitudinal,
observational study using a claims database. Drugs-real World Outcomes 8(3): 277-288.
doi:10.1007/s40801-021-00244-9
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31. Kulathunga K, Wakimoto A, Hiraishi Y, Yadav MK, Gentleman K, Warabi E, Sakasai T, Miwa Y, Mizuno
S, Takahashi S, Hamada M (2021) Albino mice with the point mutation at the tyrosinase locus showhigh cholesterol diet-induced NASH susceptibility. Scientific Reports 11(1). doi:10.1038/s41598-02100501-5
32. Yamato K, Inada K, Enomoto M, Marumoto T, Takeshima M, Mishima K (2021) Patterns of hypnotic
prescribing for residual insomnia and recurrence of major depressive disorder: a retrospective cohort
study using a Japanese health insurance claims database. BMC Psychiatry 21(1).
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33. Shimizu Y, Tamura T, Kemmochi A, Owada Y, Ozawa Y, Hisakura K, Matsuzaka T, Shimano H, Nakano
N, Sakashita S, Oda T, Ohkohchi N (2021) Oxidative stress and Liver X Receptor agonist induce
hepatocellular carcinoma in Non-alcoholic steatohepatitis model. Journal of Gastroenterology andHepatology 36(3): 800-810. doi:10.1111/jgh.15239
34. Ishii S, Suzuki T, Wakahashi K, Asada N, Kawano Y, Kawano H, Sada A, Minagawa K, Nakamura Y,
Mizuno S, Takahashi S, Matsui T, Katayama Y (2021) FGF-23 from erythroblasts promotes
hematopoietic progenitor mobilization. Blood 137(11): 1457-1467. doi:10.1182/blood.2020007172
35. Hashimoto M, Kumabe A, Kim JD, Murata K, Sekizar S, Williams A, Lu WZ, Ishida J, Nakagawa T,
Endo M, Minami Y, Fukamizu A (2021) Loss of PRMT1 in the central nervous system (CNS) induces
reactive astrocytes and microglia during postnatal brain development. Journal of Neurochemistry156(6): 834-847. doi:10.1111/jnc.15149
36. Suzuki T, Ishii S, Shinohara M, Kawano Y, Wakahashi K, Kawano H, Sada A, Minagawa K, Hamada
M, Takahashi S, Furuyashiki T, Tan NS, Matsui T, Katayama Y (2021) Mobilization efficiency is
critically regulated by fat via marrow PPAR delta. Haematologica 106(6): 1671-1683.
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39. Dong Y, Xiao C, Chen H, Yu JX, Takeoka K, Oyamada M, Kitagawa H (2021) Continuous top-k spatial–
keyword search on dynamic objects. The International Journal on Very Large Data Bases 30 141–161. doi:10.1007/s00778-020-00627-4
40. Bedont J, Toda H, Shi M, Park CH, Quake C, Stein C, Kolesnik A, Sehgal A (2021) Short and long
sleeping mutants reveal links between sleep and macroautophagy. eLife 10, e64140. doi:
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41. Seol J, Fujii Y, Inoue T, Kitano N, Tsunoda K, Okura T (2021) Effects of morning versus evening
home-based exercise on subjective and objective sleep parameters in older adults: A Randomized
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42. Kizawa T, Hosokawa K, Nishijima T, Takahashi S, Shimizu T, Ono T, Han G, Kanbayashi T, Sakurai
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1 (PRMT1) in brain development and disease. Biochimica et Biophysica Acta-General Subjects
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