Access
Venue: Tohoku University Seiryo Auditorium, Sendai, Japan
2-1 Seiryo-machi, Aoba, Sendai 980-8575, Japan
https://www.tohoku.ac.jp/en/about/map_directions.html

Seiryo Campus, Tohoku University
4

Seiryo Auditorium

Kita-Yobancho, Subway Station

School of Medicine Centennial Hall48

Bus stop "In front of
Tohoku University Hospital"

Bus stop“Tohoku Daigaku Byoin Mae”

45
Tohoku University
Hospital main gate

48
Subway Station"Kita-Yobancho"
Bus stop “Tohoku Daigaku Byoin Mae”

4

Tohoku University School of Medicine main gate

Richmond Hotel Premier Sendai Ekimae

Tohoku Medical Megabank Organization (ToMMo) Building
・1F, Atrium (18:15-, Nov 4 Round-Table Discussion)

Subway "Sendai Station" North 4 Exit

JR and Subway Sendai Station

By taxi:
10 min from Sendai Station
By subway NAMBOKU Line:
Three stops from Sendai station,
get off at “Kita-Yobancho” Station and take the exit labelled “North 2 Exit”, then walk 15 min*Visit Transportation Bureau City of Sendai website for further information:
https://www.kotsu.city.sendai.jp/english/subway/norikata.html
By bus:Catch a bus from platform 10 at the west entrance in front of Sendai Station.
bound for the “Tohoku Daigaku Byoin Mae” (for Tohoku University Hospital)
get off at “Tohoku Daigaku Byoin Mae” (for Tohoku University Hospital)
Approx. a 20 min ride
*Visit Transportation Bureau City of Sendai website for further information:
https://www.kotsu.city.sendai.jp/english/bus/noriba_sendai.html
https://www.kotsu.city.sendai.jp/english/bus/norikata.html－4－Floor Plan

Seiryo Auditorium
1st floor
CO-OP Store
CLOSED

Entrance
Hall
Poster viewing
Poster presentation

EV

University Cafeteria

Café
Tully’s

Lunch (Nov 3 - 5)
Welcome Reception (18:30-, Nov 3)

CLOSED

2nd floor

Main
Hall

closedRoom 3

Exhibition
Drink Service(Nov 3 - Nov 5)

Room 2secretariat

Room 1
Cloak

EV

Registration
Desk

－5－

Information for Participants
Registration Desk
Place: 2F Seiyo Auditorium
Date & Time: Nov 3 (Fri) 8:30 Nov 4 (Sat) 8:15 Nov 5 (Sun) 8:15 Registration Fee:
Please note that the payment must be made in Japanese yen cash at the Registration Desk.
Category

Pre-registration by website

Onsite Registration

Regular5,000 JPY

10,000 JPY*Registration Fee includes:- Name Card
- Program & Abstract Book
- Lunch box *Pre-registration Only
- Welcome Reception: 18:30-, Nov 3 at 1F Cafeteria- Round-Table Discussion: 18:15-, Nov 4 at 1F Atrium, Tohoku Medical Megabank Organization (ToMMo)
Building- Excursion Tour: Nov 5 & 6 *Pre-registration Only*Name Card, Receipt of Registration Fee and Program & Abstract Book will be provided at the on-site
Registration Desk.
<Pre-registered Participants>
Please pay the pre-registration fee and receive your Name Card and Program & Abstract Book at theregistration desk on your arrival at the venue. If you do not submit the “No Publication Policy Form” to thesecretariat, please hand in the form to the registration desk.

Cloak Room
Place: 2F Room 1
Date & Time: Nov 3 (Fri) 8:30 - 18:30
Nov 4 (Sat) 8:15 - 18:00
Nov 5 (Sun) 8:00 - 15:30*Please bring your belongings to 1F Cafeteria during Welcome Reception on Nov 3*Please bring your belongings to 1F ToMMo building during Round-Table Discussion on Nov 4*Please note that valuables will not be accepted.

Welcome Reception
18:30-, Nov 3 at 1F Cafeteria*Free for all participants

Round-Table Discussion
18:15-, Nov 4 at 1F Atrium, Tohoku Medical Megabank Organization (ToMMo) Building*See Access Map on P4.
*Free for all participants

Lunch
We will provide the lunch box at 1F Cafeteria to those who registered and applied for a lunch box in advance.

－6－

Information for Speakers
Oral presentation
For oral presentations, speakers are encouraged to bring your own laptop computer to avoid projection
troubles. Please prepare a PowerPoint presentation within the time frame indicated below. We will prepare
a projector with analogue RBG (D-Sub 15 pin) and HDMI input connector; please bring an adapter for
D-Sub 15 pin and HDMI connecter if you need. Alternatively, speakers can use computers we have prepared(Mac OS X with PowerPoint for Mac.).
Presentation

Time

Keynote lecture:

45 min including 10 min discussion

Invited talks:

40 min including 5 min discussion
30 min including 5 min discussion
20 min including 5 min discussion

Selected posters:

30 min including 5 min discussion
20 min including 5 min discussion
15 min including 3 min discussion

Poster presentation
All posters will be displayed in the poster session room during the whole conference.
Please bring the poster with you and put it up on the poster board before starting the symposium, 8:309:30AM, Nov. 3.
The poster size should be 150 cm long and 120 cm wide or smaller. Be sure to include the abstract title,
author names, and institution in capital letters at the top of your poster. The poster number will be preparedby the secretariat. The posters should be removed by yourself between 12:15 -13:00, Nov. 5.
Poster session:
Odd number: 12:25-13:55, Nov 3
Even number: 12:50-14:20, Nov 4
If your poster is selected for the “Oral presentation for selected poster”, the presenter will prepare BOTH
a poster AND a PowerPoint presentation as described above in the “Oral presentation”.
The organizing committee is planning a POSTER AWARD to a few poster presenters. The award winners
will be announced at the closing remarks on Nov. 5 afternoon.

－7－

Wi-FiWi-Fi
1. Campus Wi-Fi Service “eduroam” is available in Seiryo Auditorium with your account ID and yourpassword issued in your university / institute in advance.
2. In addition, we provide a guest account and password for TAINS Wi-Fi network. Your account ID andpassword will be on your name card.

How to connect your device to
TAINS Wi-Fi network using guest account
You can use high-speed Wi-Fi Internet connection supplied by the Tohoku University TAINS network. Below
are the instructions showing you how to set up your device on the network.
Your account ID: (your account)@guest.tohoku.ac.jp
Your password: your password
SSID: eduroam
Security: WPA2 Enterprise (AES)
Connection method: PEAP/MSCHAPv2
Rooting Certificate: Security Communication RootCA2
If you cannot succeed to make a connection, you should try NOT use this rooting certificate procedureA pproved connection strategy:
	PPTP (GRE(47/ip), 1723/tcp), OpenVPN (1194/tcp, 1194/udp), SSH (22/tcp), IPSec NAT-Traversal (4500/udp, 4500/tcp, 500/udp), HTTP (80/tcp), HTTPS (443/tcp), MSA (Message Submission Agent) (587/tcp), IMAP (143/tcp), IMAPS (993/tcp), POP3
(110/tcp), POP3S (995/tcp), SMTPS (465/tcp), FTP (21/tcp), ICMP (1/ip)

This account will be activate for a limited time and you should follow the rules below,
When you connect to SSID of TAINS, and click to open your web browser,
you can see a manual webpage that indicates how to connect to TAINS Wi-Fi.
✓ Do not give this account to another person✓ Do not share this account with another person✓ Do not act to destroy out service network✓ Do not act with this account to break the low
If you have any questions about this procedure, please contact the conference staff at anytime.

－8－Time TableTime

Nov 3 (Fri)Nov 4 (Sat)Nov 5 (Sun)

Nov 6
(Mon)

8:30

Session 8: The KEAP1-NRF2 Systemand Drug Development 1

9:00

Opening Remarks Masayuki YAMAMOTO

10:00

Keynote Lectures
9:35-11:05

KL-1 Masayuki YAMAMOTO
KL-2 Thomas W KENSLER

Session 4:
The KEAP1-NRF2 System
and Cancers 1
9:00-11:00

S4-1 Anna-Liisa LEVONEN
S4-2 Young-Joon SURH
S4-3 Gina M DENICOLA
S4-4 Kate D. SUTHERLAND

11:00

8:40-10:10

S8-1 Karen T. LIBY
S8-2 Terry W MOORE
S8-3 Akihito OTSUKI

Session 9:
The KEAP1-NRF2 Systemand Drug Development 2
10:30-12:00

12:00

13:00

11:25-12:25

S1-1 Hozumi MOTOHASHI
S1-2 Michael Ben MAJOR

Session 5:
The KEAP1-NRF2 System
and Cancers 2
11:20-12:50

S5-1 Fumiki KATSUOKA
S5-2 Liam BAIRD
S5-3 Thales PAPAGIANNAKOPOULOS
S5-4 Akira KOBAYASHI

Lunch time &Poster Discussion (ODD number)
12:25-13:55

Closing Remark

Masayuki YAMAMOTO 12:00-12:15

Lunch
12:15-13:30

Lunch time &Poster Discussion (EVEN number)
12:50-14:20

14:00

Public Lecture “Space & Health”
Session 2:
Molecular Mechanisms of theKEAP1-NRF2 System Function 2
15:00

13:55-16:05

S2-1 Albena T DINKOVA-KOSTOVA
S2-2 Ken ITOH
S2-3 Elias S.J. ARNÉR
S2-4 Takafumi SUZUKI

Session 6:
The KEAP1-NRF2 Systemand Diseases 1

13:30-15:00

14:20-15:40

S6-1 Jingbo PI
S6-2 Gerasimos SYKIOTIS
S6-3 Mi-Kyoung KWAK

16:00

17:00

Session 3:
Molecular Mechanisms of theKEAP1-NRF2 System Function 3
16:25-18:15

18:00

19:00

S3-1 Donna D ZHANG
S3-2 Youngtae JEONG
S3-3 John D. HAYES
S3-4 Nobunao WAKABAYASHI
S3-5 Tetsuro ISHII

Welcome Reception @Cafeteria
18:30-

Session 7:
The KEAP1-NRF2 Systemand Diseases 2
16:00-17:50

S7-1 Ian COPPLE
S7-2 Ana I ROJO
S7-3 Ioannis TROUGAKOS
S7-4 Florian A KARRETH
S7-5 Masaki HOSHINO

Excursion Tour
“Towards Building
the Future of Healthcare”
16:00-

Round-Table Discussion @ ToMMo atrium
18:15-－9－

Excursion Tour -15:30

Session 1: Molecular Mechanisms of
the KEAP1-NRF2 System Function 1

S9-1 Anqi ZHANG
S9-2 Sharadha DAYALAN NAIDU
S9-3 Aikseng OOI
S9-4 Xiaoxin Luke CHEN
S9-5 Antonio CUADRADO

Public Lecture: Space & Health
Information
During space flight, astronauts are subjected to extreme
conditions, including microgravity and cosmic radiation, which
disturb the homeostasis of physiological systems within thehuman body. To investigate the impacts of space flight on animal
health, experiments involving space mice have been conductedSpace Healthusing the International Space Station (ISS). However, thesuccessful live return of mice from space, or even achieving
their “space travel”, has been challenging. To overcome thishurdle, the Japan Aerospace Exploration Agency (JAXA)
recently established comprehensive mouse experimental system

During space flight, astronauts are subjected to extreme conditions, including microgravity and cosmic radiation, which disturb the homeostasis ofphysiological systems within the human body. To investigate the impacts of space flight on animal health, experiments involving space mice havebeen conducted using the International Space Station (ISS). However, the successful live return of mice from space, or even achieving their “spacetravel”, has been challenging. To overcome this hurdle, the Japan Aerospace Exploration Agency (JAXA) recently established comprehensive mouse
experimental system for space flight. The first missions employing this system, named Mouse Habitat Unit-1 (MHU-1), successfully launched twelve
wild-type male mice, all of which returned safely to Earth after approximately a one-month stay on the ISS. One salient discovery in these missions
is that ageing phenotypes, including reduced bone density and muscle mass, were significantly accelerated during space flight. Furthermore, theMHU-3 project unveiled how the deletion of Nrf2, a primary regulator of stress defense pathways, affects the health of mice staying on the ISS. The
speakers will discuss future space research utilizing murine gene knockout-disease models and will provide insights to mitigate space-induced
stresses that limit the further exploration of space by humans.

Venue

School of Medicine Centennial Hall (Seiryo Auditorium), Seiryo Campus, Tohoku University
Kato-Kosaka Hall, Sendai Astronomical Observatory

Facilitator

Panelists

for space flight. The first missions employing this system, named
Mouse Habitat Unit-1 (MHU-1), successfully launched twelve
wild-type male mice, all of which returned safely to Earthafter approximately a one-month stay on the ISS. One salient
discovery in these missions is that ageing phenotypes, including

Norishige Kanai(JAXA) Crew member on board
the International Space Station(ISS) for Expedition 54/55

Masayuki Yamamoto Satoru Takahashi(Tohoku University)
Principal investigator of
MHU-3 Project

Program
13:00 ................Door Open
13:30 –13:40.....Opening: Introduce Panelists and Facilitator
13:40 –14:20.....Lecture: Introduction of the latest space researchfrom each Panelists
14:20 –14:40.....Discussion
14:40 –15:00.....Q & A
15:00 ................Closing~ Request to participants ~・ Audio and video recording of lectures is prohibited.
・ Anyone with a fever of 37.5c or higher cannot enter.

(University of Tsukuba)
Principal investigator of
MHU-1 Project

Dai Shiba(JAXA)
Deputy Director forRodent Research

Maki Okada(JAXA)
Study coordinator of
MHU missions★Important request for cooperation★
Please take a few minutes to fill out this survey during this lecture.

URL：https://questant.jp/q/jta23022202

After the Lecture, please tell our staff that you answered the survey at theregistration desk. We will give you a small gift “Space food Jelly” forappreciation. Thank you for your kind cooperation!
*Please not that those who will join the excursion tour on Nov 5 & 6, please
fill out this survey on Nov 6.

reduced bone density and muscle mass, were significantly
accelerated during space flight. Furthermore, the MHU-3 project unveiled how the deletion of Nrf2, a
primary regulator of stress defense pathways, affects the health of mice staying on the ISS. The speakers will
discuss future space research utilizing murine gene knockout-disease models and will provide insights tomitigate space-induced stresses that limit the further exploration of space by humans.

Date
Nov 5 (Sun) 13:30 - 15:00

Venue
Kato-Kosaka Hall, Sendai Astronomical Observatory
School of Medicine Centennial Hall (Seiryo Auditorium), Seiryo Campus, Tohoku University－ 10 －

Facilitator
Norishige Kanai (JAXA)

Panelists
Maki Okada (JAXA)Dai Shiba (JAXA)
Satoru Takahashi (University of Tsukuba)
Masayuki Yamamoto (Tohoku University)

Program
13:00

Door Open

13:30-13:40

Opening: Introduce Panelists and Facilitator

13:40-14:20

Lecture: Introduction of the latest space research from each Panelists

14:20-14:40

Discussion

14:40-15:00

Q&A

15:00

Closing

Request to participants- Audio and video recording of lectures is prohibited.
- Anyone with a fever of 37.5c or higher cannot enter.
- Please take a few minutes to fill out the survey during this lecture.

Important request for cooperation
Please take a few minutes to fill out this survey during this lecture.
URL: https://questant.jp/q/jta23022202－ 11 －

Excursion Tour on Nov 5 and 6“Towards Building the Future of Healthcare”
The Tohoku Medical Megabank Organization (ToMMo) was established to overcome unprecedented
damages that occurred due to the Great East Japan Earthquake and tsunami on March 11, 2011. The missionof ToMMo is to contribute to the recovery of tsunami-affected areas through reconstructing medical systemand to build the foundations for next-generation medicine.
ToMMo has been developing five-year plans, which consist of the first, second, and third phase operations. It
has now been over 10 years since its establishment in 2012, and we are now implementing the third phase.
In the first phase, we have worked on cohort recruitment extensively. Since 2013, we have established twocohorts strategically, one is the Community-Based Cohort that targeting general residents in Miyagi and
Iwate prefectures, while the other is the Birth and Three-Generation Cohort that targeted pregnant womenand their families. The former cohort has been established in collaboration with Iwate Medical University.
Combining these two cohorts, we have been recruited a total of 157,000 people. We would like to express our
sincere gratitude to the people of Miyagi and Iwate prefectures who participated in this project.
In the second phase, we tried to create a large-scale and modern biobank that allowed us to securely store
biological samples and information that have been entrusted to us. Furthermore, we are also conducting
whole genome sequence and multi-omics analyses on these samples to develop integrated biobank, whichshare large scale information along with biological samples.
In the third phase, we have started strengthening the industry-academia collaboration system throughallowing many researchers to be able to use the samples and information stored in our biobank. We areworking on the establishment of efficient follow-up methods of our participants. We are also examining
the health status of the participants and mid- to long-term effects of earthquakes and tsunami to the healthof our participants. As one of the biggest population based biobanks in Japan, we wish to make positive
contributions to the establishment of modern biobank in Japan.
ToMMo is striving to establish a next-generation medical system, focusing on personalized healthcare andmedicine through integrating the results of cohort studies, biobank projects, and genomic-omics analyses.
Our staff is determined to work together in order to create a future medicine in which each individual canchoose suitable medical treatment and prevention approach that is backed up with strong lines of scientificevidence.
Masayuki Yamamoto
Executive Director, Tohoku Medical Megabank Organization (ToMMo)－ 12 －

ItineraryNov. 5 (Sun)
16:00

Meet at 1F, Tohoku University Seiryo Auditorium (after Special Session “Space & Health”)

16:15

Depart from Tohoku University Seiryo Auditorium to Matsushima (45min by bus)

17:00-17:45

Sightseeing: Zuiganji-temple (evening lighting)

18:00

Arrive and stay at Hotel Matsushima TAIKANSO

Nov. 6 (Mon)
9:00

Depart from Hotel (60min by bus)

10:00-11:00

Sightseeing: Earthquake remains Ishinomaki City Okawa Elementary School Ruins

11:00

Depart from Ishinomaki to Matsushima (60min by bus)

12:00-13:00

Lunch at Matsushima

13:00-14:00

Free time (Sightseeing: Entsuin-temple with beautiful autumn colors)

14:00

Depart from Matsushima to Tagajo (30min by bus)

14:30-15:00

Technical visit: ToMMo Tagajo Community support Center
Depart from Tagajo to Sendai (30min by bus)

15:30

Arrive at Sendai Station－ 13 －