Construction of Doctor’s Cosmetics Market

Building Doctors Cosmetics Market
A request from a doctor who was consulted by a female patient was thebeginning of this research and development - to reduce the irritancy andoxidizing property of whitening ingredient (hydroquinone). This research
produced a newly improved whitening ingredient (SHQ-1). OEM products
for medical institutions and other products for prescribing at hospitals are
made with making use of the basic research of the ingredient. This
ingredient has been sold to 154 companies and 1,224 medical institutions
around the world within 3 years since it was developed.

Message to the Medical Institutions and Researchers
The ingredients which are developed by our group have been received a high evaluation from manydermatologists, plastic surgeons and cosmetic surgeons.
At the present time, we continuously improve the quality of the ingredients through studies and analysisof their “safety” “efficacy” “quality stability” “compatibility with other ingredients” and “texture” using
patented technology, to prove their efficacy at the various conferences.
Over the past several years, SHQ-1 has continued to receive Excellent Evaluation and PositiveFeedbacks from the leading & trustworthy doctors in Japan.

Voices from Doctors（who used to prescribe Hydroquinone）
I prescribed hydroquinone since the past approximately 30 years…
However, patients complained of inflammation and itching, contact-related dermatitis had
been caused by only 1-2 times of use by the constitution and physical condition cameconventionally.
Therefore, I tried various Hydroquinone, but the problems did not disappear.
However, all problems disappeared after switching to SHQ-1 from 2004.”- Dermatologist with 35 years’ experience, Tokyo“I used the steroid medicine of the infinitesimal together to suppress inflammation by the stimulation on the occasion ofconventional hydroquinone prescription” Since I started to prescribe SHQ-1 to my patients, No claims to be heard (e.g.
redness, itching), and there was no need to use steroid together for the treatment.
- Formation vanity surgery specialist with12 years’ experience, Tokyo“Since SHQ-1 does not produce stimulation and a reddish tinge, I combine it with cream as medicine for external
application of the stains for these past several years and prescribe it to patients. It is also easy to use compared with theformer Hydroquinone since it is difficult to deteriorate by oxidation.”- Dermatologist with 20 years’ of experience, Tokyo

Q&A concerned with medical field
Q1. What is SHQ-1?
A1. The “first of its kind “raw material derived from Hydroquinone( a pharmaceutical ingredient).

It is highly effective, reliable and safe “Skin Whitening & Brightening” ingredient.
It is blended even in cosmetics thanks to its - “Stability & Safety ”
Many doctors around the world use the hydroquinone for treating skin blemishes
The history of this therapeutic agent for dark spot and discoloration is old, and HQ (hydroquinone) hasbeen used in Europe and the US for decades. It has also been used in Japan since the 1960s with aprescription by dermatologists.
Hydroquinone is highly effective, but the problems of the ingredient were that being easily deteriorated
if not been stored properly, having strong stimulation, and being the cause of irritation to skin, SHQ-1
was developed thanks to the cooperation of many skincare professionals in order to improve these
problems that hydroquinone had.
Thus, To put it simply, SHQ-1 is an ingredient with low irritant and hard to hurt skin. In addition,
SHQ-1 can permeate gradually and it provides a sustained mild effect to the skin. The Japanese
Dermatological Society has reported an improvement of between 10-40% using SHQ-1 overhydroquinone.
* SHQ-1 is a registered trademark of Ecology and Management Holdings Co., Ltd.

Q2. What is the safety of SHQ-1?
A2. Safety has been proven by various test data.

The important thing which we would like to mention about it that SHQ-1 ismedically proved ingredient that it is safe, end effective ingredient.
We often hear about cases of deleterious cosmetic ingredients such as
Hydroquinone mono-benzyl ether which is prohibited to add in cosmetic products or,
Rhododenol, a skin-whitening agent which may cause vitiligo-like symptoms.
However, SHQ-1 is totally different from such ingredients.
Q3.What is the effect of SHQ-1?
A3. It is effective in cases of abnormal increase of melanin, causing *blemishes and____pigmentation on small areas of skin.
____*Liver spot, freckles, post inflammatory hyperpigmentation, senile pigment freckles

The ordinal texture of hydroquinone is cream, and prevents it from changing its
color by using antioxidant. It doesn’t make the ingredient absorbing gradually.
On the other hand, SHQ-1 made it possible to absorb into skin *gradually by ourtechnology. *”gradually” describes a function which enables an active ingredient to dissolve slowly.
Thanks to the function, the ingredient gradually permeates, and is more effective
to the skin with low stimulation.