Dimethyl carbonate
August 12, 2012
Version: 1

Product Safety Summary for Dimethyl carbonate
SUBSTANCE NAME
Dimethyl carbonate
Carbonic acid, dimethyl ester
Dimethylcarbonat
DMC

GENERAL STATEMENT
Dimethyl carbonate is a colorless liquid with a pleasant odor. It is an organic compound with a wide range ofuses and applications, both in industrial and consumer level. Its main use is as raw material for the productionof plastics and as solvent for several different applications. Its use as solvent has considerably increased due
to its low hazard properties for human health and environment in comparison to other solvent alternatives.
Dimethyl carbonate is a flammable substance. Flammability is its main hazard property. Therefore, fire
prevention needs to be carefully managed.

CHEMICAL IDENTITYEC Name: dimethyl carbonate
EC-No. : 210-478-4
CAS-No. : 616-38-6
Molecular formula: C3H6O3Structural formula:

USES AND APPLICATIONS
Dimethyl carbonate is a colorless liquid used as monomer for the manufacturing of polycarbonatediols and as
raw material for the production of certain plastics. It is also used in chemical, pharmaceutical and agriculturalindustry. Dimethyl carbonate can also be found in products such as pH-regulators, flocculants, precipitants andneutralization agents. Its main use is as cleaning agent and as solvent in paints, adhesives, sealants, inks andelectrolyte solutions for batteries.

PHYSICAL CHEMICAL PROPERTIES
Dimethyl carbonate is a colorless liquid at room temperature and pressure. It has a pleasant odor.

Melting point/range: 4.65 °C at atmospheric pressure

1Dimethyl carbonate
August 12, 2012
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Boiling point/boiling range: 90.35 °C at atmospheric pressure
Decomposition temperature: Not determinedFlashpoint: 16.7 °C (closed cup) at atmospheric pressure
Flammability (solid, gaseous): highly flammable
Selfignition temperature: 458 °C at atmospheric pressure
Explosion limits:
Lower: 4.22%
Upper: 12.87%
Explosive properties: Non explosive.
Molecular weight: 90.0779 g/mol
pH value: Not applicablelog Pow: 0.354 (at 20 °C)
Vapor pressure: 7570.4 Pa at 25 °C
Vapor density: Not determined
Relative density: 1.0633 at 25 °C
Dissociation constant: Not applicable
Solubility in/Miscibility with water: 114.7 g/l (at 20 °C)
Dynamic Viscosity: 0.585 mPa.s (at 20°C)
Oxidizing properties: Not applicable

HEALTH EFFECTS
Dimethyl carbonate is a small molecule which is highly water soluble and has an octanol/water partition
coefficient of 0.354. It could be expected that it is likely to be absorbed into the body by the dermal route of
exposure and based on its moderate vapour pressure of 7.57 KPa at 25 °C and its boiling point of 90 °C, it
could also be expected that absorption through inhalation might be likely. However, according to the toxicity
studies, there was no indication of inhalatory or dermal absorption, metabolism, excretion or distribution. The
acute rat oral, dermal and inhalation studies, together with the repeat dose inhalation study and the one
generation reproductive toxicity study indicated no resultant adverse toxicity. Similarly, there was no evidenceof significant skin or eye irritation or sensitization potential.

EFFECT ASSESSMENTRESULT

Acute Toxicity (oral/dermal/inhalation)

Dimethyl carbonate is of low acute toxicity via oral, skin andinhalation routes of exposure.

Irritation/Corrosivity

Dimethyl carbonate is not irritating to the skin or to the eyes.

(skin/eye/respiratory tract)

Corrosivity was not tested on the basis of the absence ofirritation properties.

Sensitization

Based on the available data Dimethyl carbonate is not(skin/respiratory tract)considered to have skin or respiratory sensitization properties.

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Mutagenicity

Dimethyl carbonate
August 12, 2012
Version: 1
All available test data indicates that Dimethyl carbonate does
not cause mutagenic effects.

Carcinogenicity

No carcinogenicity data is available.

Reproductive Toxicity

All available data suggest that Dimethyl carbonate has noadverse fertility or reproductive effects.

Repeated Dose Exposure

Test results with oral exposure indicate that there is no marked
repeated dose toxicity.
Repeated dose toxicity via the inhalation and dermal exposure
route have not been tested.

ENVIRONMENTAL EFFECTS
Dimethyl carbonate is partitioned into air and water with negligible amounts in soil, sediment and biota. In theaqueous environment it is considered to be readily biodegradable. Its low partition coefficient suggests thatDimethyl carbonate has low bioaccumulation potential. All available information indicates that Dimethylcarbonate is not environmentally hazardous.

EFFECT ASSESSMENTRESULT

Aquatic Toxicity

Fish, daphnia, algae and plant studies indicate that theenvironmental toxicity of dimethyl carbonate is low.

FATE AND BEHAVIORRESULT

Biodegradation

Dimethyl carbonate is readily biodegradable in water.
Biodegradability in soil and sediment is not relevant.

Bioaccumulation potential

Based on the low partition coefficient it is concluded that thebioaccumulation potential of Dimethyl carbonate is very low
and does not need to be studied further.

PBT/vPvB conclusion

Dimethyl carbonate is neither PBT nor vPvB based on
biodegradation and bioaccumulation results and no hazard toaquatic species.

EXPOSURE
Human Health
Exposure to Dimethyl carbonate can occur to workers in industrial facilities where it is produced, stored,
handled or processed. Professional users or consumers may come into contact with Dimethyl carbonate
through commonly used formulated products, such as paints, sealants, adhesives, inks, cleaners and batteries.
Based on the physical properties of Dimethyl carbonate, skin contact and inhalation are the most likely routesof exposure. The health effects of dimethyl carbonate are such that it does not pose a risk to any kind of user.
The most relevant risk of Dimethyl carbonate is its flammability. Therefore, fire prevention is the most relevant
3Dimethyl carbonate
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measure to protect workers.

Environment
Dimethyl carbonate may be released to the environment in air and water from manufacturing and industrial use
facilities. All identified uses of the substance have been assessed as safe for the environment. The physicalproperties of the substance are such that exposure to sediment is unlikely. Indirect release to sediment is also
unlikely since the substance is readily biodegradable.

RISK MANAGEMENT RECOMMENDATIONS
Dimethyl carbonate poses very low human health and environmental risks. However, it is a good practice totrain personnel that handle the substance and to protect workers who may be exposed to Dimethyl carbonate
by taking the usual precautionary measures to protect against chemical exposure. Therefore, protective
clothing, gloves and safety glasses should be worn when handling Dimethyl carbonate. Unless highconcentrations are present, respiratory protection is not required, provided ventilation is good.
Flammability is the main hazard property of Dimethyl carbonate, therefore risk management needs to focus onfire prevention. Containers and equipment containing Dimethyl carbonate should be correctly labeled clearly
indicating its flammability. All electrical installations should be explosion proof. The creation and accumulationof static discharge during transfer of the substance should be controlled by precautionary measures such asgrounding and bonding containers and equipment. Dimethyl carbonate should be stored in a special, ventilated,enclosure, grouped by risk category and adequately isolated from incompatible substances or substances that
may give rise to hazardous reactions. In addition, Dimethyl carbonate should be stored in undamaged, secure
packaging. Only those quantities necessary for immediate work should be kept in the work area. Open pouring
should be avoided and operations involving the possible release of liquid, vapor, dust, etc. should be carriedout using closed processes or, failing this, in well-ventilated areas or in installations with local extractionsystems.
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Dimethyl carbonate is included in the OECD list of High Production Volume (HPV) chemicals.
Dimethyl carbonate is listed in the following Chemical Inventories: AICS, EINECS, IECSC, Canada DSL, KECI,ECNS, TSCA, PICCS, NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Flammable liquid: Flammable liquid Category 2; H225 Highly flammable liquid and vapor.

4Dimethyl carbonate
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Version: 1Labeling according to REGULATION (EC) No 1272/2008:
Pictogram:

Signal word: DangerHazard statements: H225: Highly flammable liquid and vapor.

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company: UBE Industries, Ltd.
Department: Fine Chemicals Business Unit
Address: Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo
Town/Country: Japan
Postal code: 105-8449
E-mail: ube-fine@ube-ind.co.jp

Additional information can be found at:
http://www.ube.co.jp

GLOSSARY
Acute toxicity

Harmful effect resulting from a single or short term exposure to asubstance.

AICS

Australian Inventory of Chemical Substances.

Biodegradation

Decomposition or breakdown of a substance under natural
conditions (actions of micro-organisms etc).

Bioaccumulation

Progressive accumulation in living organisms of a chemical
substance present in the environment.

Canadian DSL

Domestic Substances List of Canada.

CarcinogenicitySubstance effects causing cancer.

CAS

Chemical Abstracts Service (division of the American ChemicalSociety).

Chronic toxicity

Harmful effect after repeated exposures or long term exposure to asubstance.

EINECS

European Inventory of Existing Commercial Chemical Substances

ENCS

Existing Notified Chemical Substances (Japan).

5Flash point

Dimethyl carbonate
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The lowest temperature at which vapor of the substance may form
an ignitable mixture with air.

Genotoxicity

Substance effect that causes damage to genes, including
mutagenicity and clastogenicity.

GHS

Globally Harmonized System of Classification and Labeling ofChemicals

HPVHigh Production Volume Chemicals.

Hydrolyze

Undergo hydrolysis; decompose by reacting with water.

IECSC

Inventory of Existing Chemical Substances Produced or Importedin China.

Intermediate

Substance that is manufactured for and consumed in or used forchemical processing in order to be transformed into anothersubstance.

KECI

Korean Existing Chemical Inventory.

Monomer

Means a substance which is capable of forming covalent bonds
with a sequence of additional like or unlike molecules under theconditions of the relevant polymer-forming reaction used for theparticular process.

MutagenicitySubstance effect that cause mutation on genes.

NZIoC

New Zealand Inventory of Chemicals

PBT

Persistent, bioaccumulative, toxic chemical.

Persistence

Refers to the length of time a compound stays in the environment,
once introduced.

PICCS

Philippine Inventory of Chemicals and Chemical Substances.

Risk Management Measures

Engineering controls, conditions and protective equipment needed
to be implemented to ensure that the risks to human health and theenvironment are adequately controlled.

REACH (EC) No. 1907/2006

European Commission Regulation concerning the Registration,
Evaluation, Authorization and Restriction of Chemicals.

REGULATION (EC) No 1272/2008

European Commission Regulation on Classification, Labeling andPackaging of Substances and Mixtures.

Reproductive toxicity

Including teratogenicity, embryotoxicity and harmful effects onfertility.

Sensitizing

Allergenic.

Sediment

Topsoil, sand and minerals washed from land into water forming in
the end a layer at the bottom of rivers and sea.

TSCA

Toxic Substance Control Act (USA).

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Vapor pressure

Dimethyl carbonate
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A measure of a substance’s property to evaporate.

vPvB

Very persistent, very bio-accumulative.

DISCLAIMER
This information is furnished without warranty, expressed or implied, except that it is accurate to the best
knowledge of UBE INDUSTRIES, LTD. The data on this sheet related only the specific material designatedherein. UBE INDUSTRIES, LTD. assumes no legal responsibility for use or reliance upon these data.

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