SAFETY DATA SHEETSECTION 1: PRODUCT AND COMPANY INFORMATION
Product name: Component K
Contact:
Elixirgen Scientific, Inc.
855 N. Wolfe St., Suite 631
Baltimore, MD 21205
Phone: +1 443-869-5420
https://www.elixirgensci.com
SECTION 2: HAZARD IDENTIFICATIONGHS classification of the substance/mixture:
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 4), H227
Acute toxicity, Oral (Category 4), H302
Acute aquatic toxicity (Category 2), H401
For the full text of the H-Statements mentioned in this Section, see Section 16.
GHS label elements, including precautionary statements:
Pictogram none
Signal word

Warning

Hazard statement(s)H227
Combustible liquid.
H302
Harmful if swallowed.
H401
Toxic to aquatic life.
Precautionary statement(s)P210
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P264
Wash skin thoroughly after handling.
P270
Do not eat, drink or smoke when using this product.
P273
Avoid release to the environment.
P280
Wear protective gloves/ protective clothing/ eye protection/ faceprotection.
P301 + P312
IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you
feel unwell.
P330
Rinse mouth.
P370 + P378
In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for1

P403 + P235
P501

extinction.
Store in a well-ventilated place. Keep cool.
Dispose of contents/ container to an approved waste disposal plant.

Other hazards which do not result in the classification or are not covered by the GHS:None.
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS SUBSTANCE
Hazardous components
component

Classification

Concentration

Dimethyl sulfoxide

Flam. Liq. 4; H227<= 100 %TretinoinAcute Tox. 4; Aquatic Acute2; H302, H401

0.2

For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance. Move out ofdangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult aphysician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2)
and/or in section 11.
Indication of any immediate medical attention and special treatment needed2

No data available.
SECTION 5: FIRE-FIGHTING MEASURES
Suitable extinguishing media:
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon
dioxide. For large fires, apply water from as far as possible. Use very large quantities(flooding) of water applied as a mist or spray; solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.
Specific hazards arising from the substance or mixture:
Carbon oxides, Sulphur oxides.
Special protective equipment and precautions for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures:
Avoid breathing vapours, mist or gas. Remove all sources of ignition. Beware of vapours
accumulating to form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
Environmental precautions:
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Contain spillage, and then collect with an electrically protected vacuum cleaner or by
wet-brushing and place in container for disposal according to local regulations (see section
13). Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
SECTION 7: HANDLING AND STORAGE
Precautions for safe handling:
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities:3

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
Specific end uses:
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters:
Components with workplace control parameters
Components with workplace control parameters
Component

CAS-No.

ValueControlparameters

Basis

Dimethylsulfoxide

67-68-5

TWA

250.000000
ppm

USA. Workplace Environmental
Exposure Levels (WEEL)

Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
Personal protective equipment:
Respiratory:
In case of insufficient ventilation wear suitable respiratory
equipment.
Eyes:
Safety goggles or splash guard safety glasses.
Body:
Lab coat and gloves.
Hygiene measures:
Handle in accordance with good industrial hygiene and safety
practice.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance:
Odor:
Odor threshold:pH:
Melting point/freezing point:
Initial boiling point and boiling range:
Flash point:
Evaporation rate:
Flammability (solid, gas):

Form: liquid, clear
Color: colorless
No data available.
No data available.
No data available.
Melting point/range: 16 - 19 °C (61 - 66 °F)
189 °C (372 °F)
87 °C (189 °F) - closed cup
No data available.
No data available.
4Upper/lower flammability or explosive limits:
Vapor pressure:
Vapor density:
Relative density:
Water Solubility(ies):
Partition coefficient: n-octanol/water:
Auto-ignition temperature:
Decomposition temperature:
Viscosity:
Explosive properties:
Oxidizing properties:

Upper explosion limit: 42 %(V)
Lower explosion limit: 3.5 %(V)0.55 hPa (0.41 mmHg) at 20 °C (68 °F)
2.70 - (Air = 1.0)
No data available.
completely miscible
No data available.
No data available.
No data available.
No data available.
No data available.
No data available.

Other safety information
Relative vapour density 2.70 - (Air = 1.0)
SECTION 10: STABILITY AND REACTIVITY
Reactivity:
Chemical stability:
Possibility of hazardous reactions:
Conditions to avoid:
Incompatible materials:

No data available.
Stable under recommended storage conditions.
No data available.
Heat, flames, and sparks.
Acid chlorides, Phosphorus halides, Strong acids/alkalis,
Strong oxidizing/reducing agents
Hazardous decomposition products: Other decomposition products - No data available
In the event of fire: see section 5SECTION 11: TOXICOLOGICAL INFORMATION
Acute toxicity:
Dimethyl sulfoxide
LD50 Oral - Rat - 14,500 mg/kg
LC50 Inhalation - Rat - 4 h - 40250 ppm
LD50 Dermal - Rabbit - > 5,000 mg/kg
Tretinoin
LD50 Oral - rat - 2,000 mg/kg
Inhalation: no data available
LD50 Dermal - rabbit - > 2,500 mg/kg
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Tretinoin
5

Eyes - rabbit
Result: No eye irritation
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity
Dimethyl sulfoxide
Mouselymphocyte
Cytogenetic analysis
Mouse
lymphocyte
Mutation in mammalian somatic cells.
Rat
Cytogenetic analysis
Mouse
DNA damage
Carcinogenicity
Dimethyl sulfoxide
Carcinogenicity - Rat - Oral
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages: Other:
Tumors.
Carcinogenicity - Mouse - Oral
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Leukaemia Skin andAppendages: Other: Tumors.
IARC:
ACGIH:NTP:
OSHA:

No component of this product present at levels greater than or equal to 0.1% isidentified as probable, possible or confirmed human carcinogen by IARC.
No component of this product present at levels greater than or equal to 0.1% isidentified as a carcinogen or potential carcinogen by ACGIH.
No component of this product present at levels greater than or equal to 0.1% isidentified as a known or anticipated carcinogen by NTP.
No component of this product present at levels greater than or equal to 0.1% isidentified as a carcinogen or potential carcinogen by OSHA.

Reproductive toxicity
Dimethyl sulfoxide
6Reproductive toxicity - Rat - Intraperitoneal
Effects on Fertility: Abortion.
Reproductive toxicity - Rat - Intraperitoneal
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total
number of implants).
Reproductive toxicity - Rat - Subcutaneous
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total
number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter; measured before birth).
Reproductive toxicity - Mouse - Oral
Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants perfemale; total number of implants per corpora lutea). Effects on Embryo or Fetus: Fetotoxicity(except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal
system.
Developmental Toxicity - Mouse - Intraperitoneal
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Musculoskeletal system.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
Dimethyl sulfoxide
RTECS: PV6210000
Tretinoin
RTECS: VH6475000
Exposure may cause irritation of eyes, mucous membranes, upper respiratory tract and skin.
Effects due to ingestion may include:, Nausea, Fatigue, Headache
To the best of our knowledge, the chemical, physical, and toxicological properties have not beenthoroughly investigated.
Eyes - Eye disease - Based on Human Evidence
SECTION 12: ECOLOGICAL INFORMATION7

Toxicity:Dimethyl sulfoxide
Toxicity to fish
Toxicity to daphnia
and other aquatic
invertebrates
Toxicity to algae
Tretinoin
Toxicity to fish

LC50 - Pimephales promelas (fathead minnow) - 34,000 mg/l - 96 h
LC50 - Oncorhynchus mykiss (rainbow trout) - 35,000 mg/l - 96 h
EC50 - Daphnia magna (Water flea) - 24,600 mg/l - 48 h(OECD Test Guideline 202)
EC50 - Pseudokirchneriella subcapitata (green algae) - 17,000 mg/l - 72 h
(OECD Test Guideline 201)
LC50 - Danio rerio (zebra fish) - 4.64 mg/l - 96 h

Persistence and degradabilityDimethyl sulfoxide
Biodegradability
Result: 31 % - According to the results of tests of biodegradability thisproduct is not readily biodegradable.
(OECD Test Guideline 301D)
Tretinoin
Biodegradability Result: > 60 % - Readily biodegradable.
Bioaccumulative potential
No data available.
Mobility in soil
No data available.
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
Other adverse effects
May be harmful to the aquatic environment.
Stability in water - 0.12 - 1.2 h at 30 °CSECTION 13: DISPOSAL INFORMATION
ProductThis combustible material may be burned in a chemical incinerator equipped with an afterburnerand scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: TRANSPORT INFORMATION
Dimethyl sulfoxide
DOT (US)NA-Number: 1993 Class: NONE Packing group: III
Proper shipping name: Combustible liquid, n.o.s. (Dimethyl sulfoxide) (Dimethyl sulfoxide)
Poison Inhalation Hazard: No
IMDG
Not dangerous goods.
IATA
Not dangerous goods.
Tretinoin
DOT (US)Not dangerous goods
IMDG
UN number: 3077 Class: 9 Packing group: III EMS-No: F-A, S-F
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
(Tretinoin)
Marine pollutant: Marine pollutant
IATA
UN number: 3077 Class: 9 Packing group: III
Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Tretinoin)
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings andcombination packagings containing inner packagings with Dangerous Goods > 5L for liquids or> 5kg for solids.

SECTION 15: REGULATORY INFORMATIONUS Federal Regulations:
SARA 302 Components.
No chemicals in this material are subject to the reporting requirements of SARA
Title III, Section 302.
SARA 313 Components
This material does not contain any chemical components with known CAS
9numbers that exceed the threshold (De Minimis) reporting levels established bySARA Title III, Section 313.
SARA 311/312 Hazards
No SARA Hazards
US State regulations:
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
CAS-No.
67-68-5
302-79-4

Dimethyl sulfoxide
Tretinoin
New Jersey Right To Know Components

CAS-No.
67-68-5
302-79-4

Dimethyl sulfoxide
Tretinoin

California Prop. 65 Components
This product does not contain any chemicals known to State of California tocause cancer, birth defects, or any other reproductive harm.
SECTION 16: OTHER INFORMATION
Dimethyl sulfoxide
HMIS Rating
Health hazard:
Chronic Health Hazard:
Flammability:
Physical Hazard:
NFPA Rating
Health hazard:
Fire Hazard:
Reactivity Hazard:
Tretinoin
HMIS Rating
Health hazard:
Chronic Health Hazard:
Flammability:

0200201010

Physical Hazard
NFPA Rating
Health hazard:
Fire Hazard:
Reactivity Hazard:

0000

Other comments:
The information provided herein is based on sources believed to be reliable as of 12/14/2017
and pertains only to the material designated. Elixirgen Scientific, Inc. makes no warranty orrepresentation to its completeness, accuracy, or currency, and assumes no liability resulting fromits use. This material is intended for use by persons with pertinent technical skills for its
intended use, the product’s safe use, and the product’s proper disposal. Disposal of hazardous
material may be subjected to federal, state or local laws or regulations.
Restriction of use:

For research use only.

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