Ammoniu
um SulphateeAugust 12, 2012
Version: 1

Producct Safetyy Summ
mary forr Ammo
onium SSulphateeSUBSTANNCE NAME
EAmmonium Sulphate
Ammonium sulfate
Ammoniumssulfat
Diammonium
m sulphate
Di-ammonium sulfate
d di-ammoniu
um salt
Sulfuric acidSulfuric acidd di-ammoniu
um salt (1:2)
Mascagnite

GENERALL STATEMENT
Ammonium Sulphate is a white odorlless solid pro
oduct. It is mainlymused foor fertilizer appplications, butb it hasvarious othe
er uses in thee chemical annd pharmace
eutical industtry as well ass for insecticcides, herbicides,fungicides and flame retaardants. Con
nsumer appli cations are suchsthat connsumer expoosure will typ
pically beinfrequent, fo
or brief perio
ods and to sm
mall quantitie
es or low con
ncentrations. Ammonium Sulphate is not known toocause adverrse human heealth or environmental efffects and it is not classiffied as a danngerous product. The
usual genera
al precaution
nary measure
es to preventt worker and environmental exposuree to chemicals should alsoobe taken when handling Ammonium Sulphate in industrial uses. No other specific riskk management measuress
are required.

CHEMICAAL IDENTIT
TYEC Name: aammonium sulphate
EC-No. : 231-984-1
7783-20-2
CAS-No. : 7
Molecular fo
ormula: H3N
N.1/2H2O4S
SStructural fformula:

USES ANDD APPLICAATIONSn of sulphuric acid and/or oleum with ammonia. Ammonium
Ammonium Sulphate is obtainedoby neutralizationnA
Sulphate cann also be obtained in thee caprolactam
m manufacturing process. The primarry applicationn ofat, it is used in a variety ofAmmonium Sulphate is asa a fertilizerr. Besides thao applicationns. It is usedd as a pHcorrective ag
gent and as chemicalc
inte
ermediate in a range of chemicalcman
nufacturing pprocesses. Itt finds also1

Ammonium Sulphate
August 12, 2012
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application in insecticides, herbicides and fungicides, as an ingredient in pharmaceutical and cosmeticproducts, as well as in flame retardants and as laboratory chemicals. Although the substance may becontained in certain products for professional or consumer use, Ammonium Sulphate is mainly applied in pureor more concentrated form in products for industrial use.

PHYSICAL CHEMICAL PROPERTIES
Ammonium Sulphate is a white odorless crystalline solid at room temperature and pressure.

Melting point/range: >280 °C
Boiling point/boiling range: Not applicable, as the substance decomposes before boiling
Decomposition temperature: 280 °C
Flammability (solid, gaseous): Product is not flammable. It does not release flammable gases in contact
with water.
Ignition temperature: Not determined
Explosion limits:
Lower: Not determined
Upper: Not determined
Molecular weight: 132.1395 g/molpH value: 5-6log Pow: Not applicable
Vapor pressure: 4.053E-9 hPa at 25 °C
Relative density: 1.77 g/cm3 at 25 °C
Dissociation constant: Not applicable, as the substance is a salt
Solubility in/Miscibility with water: 767 g/l (at 20 °C)

HEALTH EFFECTS
Ammonium Sulphate is not classified as a hazardous substance. Its acute toxicity is low via all exposure routes.
Studies have not shown long term effects or CMR properties. Ammonium Sulphate has neither irritant nor
sensitizing properties. If it is taken up in the body via ingestion or inhalation, then it dissociates in theammonium and sulphate ions (NH4 +, SO4 2-). Ammonium is an endogenous substance that serves a majorrole in the maintenance of the acid-base balance. Sulphate is a normal intermediate in the metabolism ofendogenous sulphur compounds and is excreted unchanged or in conjugated form in urine. Inhalation ofammonium in dust form should be avoided.

EFFECT ASSESSMENTRESULT

Acute Toxicity (oral/dermal/inhalation)

Ammonium Sulphate is of low acute toxicity via oral, skin andinhalation routes of exposure.

Irritation/Corrosivity

Ammonium Sulphate is not irritating to the skin or to the eyes.

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Ammonium Sulphate
August 12, 2012
Version: 1(skin/eye/respiratory tract)
Sensitization

Based on the available data Ammonium Sulphate is not(skin/respiratory tract)considered to have skin or respiratory sensitization properties.

Mutagenicity

Available in/vitro and in/vivo data indicate that Ammonium
Sulphate does not cause mutagenic effects.

Carcinogenicity

No evidence of a carcinogenic potential was observed in
carcinogenicity studies addressing oral exposure.

Reproductive Toxicity

Studies have not shown any fertility and teratogenicity effects.
Therefore Ammonium Sulphate is not considered as toxic forreproductivity.

Repeated Dose Exposure

There is no information related to repeated exposure via theinhalation route. The information on repeated exposure via theoral and dermal route suggests that there is no marked
repeated dose toxicity.

ENVIRONMENTAL EFFECTS
In aqueous solution, ammonium salts are completely dissociated into the ammonium ion and thecorresponding anion, in this case the sulphate ion. Un-ionized ammonia (NH3) exists in the aquaticenvironment and the fraction of un-ionized ammonia steeply increases with elevated pH value or temperature.
It is well known that toxicity to aquatic organisms has been attributed to un-ionized ammonia species, and NH4+ species is considered to be non- or significantly less-toxic. Therefore toxicity values for ammonium salts(such as: ammonium -sulphates, phosphates, carbonates, chlorides or nitrates), where the major toxic
component is ammonia, can be considered as equivalent.

EFFECT ASSESSMENTRESULT

Aquatic Toxicity

Ammonium Sulphate is almost totally dissociated inammonium and sulphate ions in water. Depending on the pHof the water the ammonium- ion is in equilibrium with someunionized ammonia. The concentration of free ammonia is
generally low. Therefore the overall aquatic toxicity ofAmmonium Sulphate is also low.

FATE AND BEHAVIORRESULT

Biodegradation

Biodegradation criteria do not apply due to the inorganic
nature of Ammonium Sulphate and its presence in theenvironment in ionic form.

Bioaccumulation potential

Bioaccumulation is not expected due to the high water3Ammonium SulphateAugust 12, 2012
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solubility and the ionic nature of Ammonium Sulphate.
PBT/vPvB conclusion

Ammonium Sulphate does not meet the criteria for PBT andvPvB classification.

EXPOSURE
Human Health
Exposure can occur either in Ammonium Sulphate manufacturing facilities, by other industrial users ofAmmonium Sulphate or by professional users. Based on its physical properties, ingestion or skin contact are
the most likely routes of exposure. Of all uses of Ammonium Sulphate the uses in insecticides, herbicides andfertilizers are probably the only ones that may cause some degree of exposure to the general population.
However, in these applications the general population is only exposed to Ammonium Sulphate in diluted form.
Consumer applications are such that consumer exposure will typically be infrequent, for brief periods or insmall quantities. Therefore the use of Ammonium Sulphate by the consumer is not considered to pose a healthrisk.

Environment
Ammonium Sulphate occurs in the environment only in its dissociated form, i.e. as ammonium and sulphateions. Therefore there is no environmental exposure to Ammonium Sulphate itself. The ammonium ion is inequilibrium with non-ionized ammonia, which itself is a harmful substance. However, under typicalenvironmental conditions, the concentration of non-ionized ammonia is so low that it poses no risk. Therefore,
all uses of Ammonium Sulphate are considered to be safe for the environment.

RISK MANAGEMENT RECOMMENDATIONS
Ammonium Sulphate is not known to cause adverse human health or environmental effects. However it is agood practice to train personnel that handle the substance and to protect workers who may be exposed toAmmonium Sulphate by taking the usual precautionary measures to protect against chemical exposure.
Therefore protective clothing, gloves and safety glasses with side shields should be worn when handlingAmmonium Sulphate. It is recommended to prevent the formation of dust, to avoid contact with eyes, skin andclothing. Good ventilation at the workplace should be provided and local suction extraction should be installed
if dust formation cannot be avoided. Respiratory protection should be worn if local extraction is absent orinsufficient. Soiled and contaminated clothing should be removed. Ammonium Sulphate should be kept awayfrom foodstuffs, beverages and feed. Workers should not eat, drink, smoke or sniff while working with theproduct and they should wash their hands before breaks and at the end of work. Ammonium Sulphate should
be stored in dry conditions and away from water, alkaline substances, nitrites and nitrates. For environmental
protection in case of accidental release: do not allow product to reach sewage system or any water course.
Retain and dispose of contaminated wash water.

STATE AGENCY REVIEW4

Ammonium SulphateAugust 12, 2012
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This substance has been registered under REACH (EC) No. 1907/2006.
Ammonium Sulphate is included in the OECD list of High Production Volume (HPV) chemicals.
Ammonium Sulphate is listed in the following Chemical Inventories: TSCA, EINECS, ENCS, AICS, Canadian
DSL, KECI, PICCS, IECSC, and NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.

Labeling according to REGULATION (EC) No 1272/2008:
Pictogram: Signal word: Hazard statements: CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company: UBE Industries, Ltd.
Department: Caprolactam Business Unit
Address: Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo
Town/Country: Japan
Postal code: 105-8449
E-mail: ube-cpl@ube-ind.co.jp

Additional information can be found at:
http://www.ube.co.jp

GLOSSARY
Acute toxicity

Harmful effect resulting from a single or short term exposure to asubstance.

AICS

Australian Inventory of Chemical Substances.

Biodegradation

Decomposition or breakdown of a substance under naturalconditions (actions of micro-organisms etc).

Bioaccumulation

Progressive accumulation in living organisms of a chemical
substance present in the environment.

Canadian DSL

Domestic Substances List of Canada.

Carcinogenicity

Substance effects causing cancer.

CAS

Chemical Abstracts Service (division of the American ChemicalSociety).

5Chronic toxicity

Ammonium Sulphate
August 12, 2012
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Harmful effect after repeated exposures or long term exposure to asubstance.

EINECS

European Inventory of Existing Commercial Chemical Substances

ENCS

Existing Notified Chemical Substances (Japan).

Flash point

The lowest temperature at which vapor of the substance may form
an ignitable mixture with air.

Genotoxicity

Substance effect that causes damage to genes, including
mutagenicity and clastogenicity.

GHS

Globally Harmonized System of Classification and Labeling ofChemicals

HPV

High Production Volume Chemicals.

Hydrolyze

Undergo hydrolysis; decompose by reacting with water.

IECSC

Inventory of Existing Chemical Substances Produced or Imported
in China.

Intermediate

Substance that is manufactured for and consumed in or used forchemical processing in order to be transformed into anothersubstance.

KECI

Korean Existing Chemical Inventory.

Monomer

Means a substance which is capable of forming covalent bonds
with a sequence of additional like or unlike molecules under theconditions of the relevant polymer-forming reaction used for theparticular process.

Mutagenicity

Substance effect that cause mutation on genes.

NZIoC

New Zealand Inventory of Chemicals

PBT

Persistent, bioaccumulative, toxic chemical.

Persistence

Refers to the length of time a compound stays in the environment,
once introduced.

PICCS

Philippine Inventory of Chemicals and Chemical Substances.

Risk Management Measures

Engineering controls, conditions and protective equipment needed
to be implemented to ensure that the risks to human health and theenvironment are adequately controlled.

REACH (EC) No. 1907/2006

European Commission Regulation concerning the Registration,
Evaluation, Authorization and Restriction of Chemicals.

REGULATION (EC) No 1272/2008

European Commission Regulation on Classification, Labeling andPackaging of Substances and Mixtures.

Reproductive toxicity

Including teratogenicity, embryotoxicity and harmful effects onfertility.

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Sensitizing

Allergenic.

Sediment

Topsoil, sand and minerals washed from land into water forming in
the end a layer at the bottom of rivers and sea.

TSCA

Toxic Substance Control Act (USA).

Vapor pressure

A measure of a substance’s property to evaporate.

vPvB

Very persistent, very bio-accumulative.

DISCLAIMER
This information is furnished without warranty, expressed or implied, except that it is accurate to the best
knowledge of UBE INDUSTRIES, LTD. The data on this sheet related only the specific material designatedherein. UBE INDUSTRIES, LTD. assumes no legal responsibility for use or reliance upon these data.

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