1,6-Hexanediol
August 12, 2012
Version: 1

Product Safety Summary for 1,6-Hexanediol
SUBSTANCE NAME
Hexanediol
Hexane-1,6-diol
Hexan-1,6-diol
1,6-Hexanediol
1,6-Hexanediol (8CI, 9CI)
1.6-Hexandiol
1,6- Dihydroxyhexane
Hexamethyleneglycol
Hexamethylenediol
omega.-Hexanediol
alpha.,.omega.-Hexanediol

GENERAL STATEMENT
1,6-Hexanediol is a white solid with characteristic odor. It is neither hazardous for human health nor forthe environment. 1,6-Hexanediol has a wide range of applications. It has two functional groups which areuseful in the production of various polymers and plastic products. But it also finds application in otherchemical processes and is contained in different consumer products.

CHEMICAL IDENTITYEC Name: hexane-1,6-diol
EC-No. : 211-074-0
CAS-No. : 629-11-8
Molecular formula: C6H14O2
Structural formula:

USES AND APPLICATIONS
1,6-Hexanediol is obtained after treatment of the mixture of products resulting from the oxidation ofcyclohexane with air. 1,6-Hexanediol is used to produce materials made of polyester or polyurethane, asmonomer for the manufacture of polyesterpolyols, polycarbonatedioles and acrylic monomers, for theproduction of molecules that act as reactive diluents, for the production of halogenated substances andfor the production of adhesives, putties and sealing compounds, cleaners and auxiliary agents.
1,6-Hexanediol is also used in the processes to produce hydrogen, hydrogen peroxide, sodium perborate
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1,6-Hexanediol
August 12, 2012
Version: 1and peroxyacetic acid and as an intermediate for pharmaceutical products. It is used as an ingredient forthe production of polymeric thickeners, plasticizers for polyvinyl chloride, sizing agents, surfactants, forstarches and chemically modified starch for application in the paper, textile and food industry and for
personal hygiene products like shampoo, creams, as well as for paints.

PHYSICAL CHEMICAL PROPERTIES
1,6-Hexanediol is a white solid at room temperature. It has a characteristic odor.

Melting point/range: 39.5 – 42.1 °C
Boiling point/boiling range: 250 °C at 1013 hPa
Decomposition temperature: Not determinedFlashpoint: 136 °C
Flammability (solid, gaseous): Combustible, but not highly flammable solid
Selfignition temperature: 320 °CExplosion limits:Lower: 6.6 %Upper: 16 %Explosive properties: Non explosive.
Molecular weight: 118.1742 g/mol
pH value: 7.6 at 20 °C and 500 g/l
log Pow: 0 (at 25 °C)
Vapor pressure: 0.000666 hPa at 25 °C
Vapor density: Not determined
Relative density: 0.96 g/cm3 at 20 °C
Solubility in/Miscibility with water: Miscible
Oxidizing properties: No oxidizing properties

HEALTH EFFECTS
1,6-Hexanediol has no marked health hazard properties. Its acute toxicity is very low via all tested routes ofexposure (oral, skin and inhalation). It has no irritation or sensitization effects. Repeated dose and long term
health or reproductive effects could not be established either. Its physical properties give no rise to concern.
The flammability of hexanediol is low. Therefore, 1,6-Hexanediol has a very low overall human health hazard
potential.

EFFECT ASSESSMENTRESULT

Acute Toxicity (oral/dermal/inhalation)

1,6-Hexanediol is of low acute toxicity via all routes ofexposure.

Irritation/Corrosivity

1,6-Hexanediol is not irritating to the skin or to the eyes.

2(skin/eye/respiratory tract)

1,6-Hexanediol
August 12, 2012
Version: 1Corrosivity was not tested on the basis of the absence ofirritation properties.

Sensitization

Based on the available data 1,6-Hexanediol is not considered(skin/respiratory tract)

to have skin or respiratory sensitization properties.

Mutagenicity

All available in vitro test data indicates that 1,6-Hexanediol
does not cause mutagenic effects.

Carcinogenicity

No carcinogenicity data has been generated due to thenegative mutagenicity results.

Reproductive Toxicity

Screening test information indicates that 1,6-Hexanediol has
no adverse reproductive effects.

Repeated Dose Exposure

Oral repeated dose test results with 1,6-Hexanediol suggestthat no marked toxicity should be expected. Dermal andinhalation repeated dose exposure testing is considered
unnecessary based on expected exposure routes and theresult of the oral repeated dose test.

ENVIRONMENTAL EFFECTS
The results of all acute aquatic studies on fish, algae, plants and invertebrates indicate a low environmental
acute hazard potential for 1,6-Hexanediol. 1,6-Hexanediol is readily biodegradable and it has a very low
bioaccumulation potential. Considering all available data on biotic and abiotic degradation, bioaccumulationand toxicity, it can be stated that the substance is neither persistent nor toxic to the environment and that it will
not bio-accumulate. Overall, 1,6-Hexanediol has a very low environmental hazard potential.

EFFECT ASSESSMENTRESULT

Aquatic Toxicity

Fish, daphnia, algae and plant studies indicate that the aquatic
toxicity of 1,6-Hexanediol is low.

FATE AND BEHAVIORRESULT

Biodegradation

1,6-Hexanediol is readily biodegradable.

Bioaccumulation potential

1,6-Hexanediol will preferentially distribute to water. Based on
the low partition coefficient it is concluded thatbioaccumulation is not expected.

PBT/vPvB conclusion

Based on its low toxicity, bioaccumulation potential and readybiodegradability, 1,6-Hexanediol does not meet the criteria for
PBT or vPvB.

EXPOSURE
Human Health31,6-Hexanediol
August 12, 2012
Version: 1
1,6-Hexanediol is used in many different applications. In industrial sites, it is used for the production ofhydrogen, hydrogen peroxide, sodium perborate and peroxyacetic acid. But its main industrial use is as
monomer or reactant; therefore, 1,6-Hexanediol will no longer be present as such in downstream products,
practically eliminating the exposure potential for professional users and consumers.
On the other hand, 1,6-Hexanediol is contained in formulated products of usual use, such as adhesives, putties,sealing compounds, cleaners, paints and inks, synthetic resins and personal hygiene products (shampoo,creams, etc.). In all previous cases, 1,6-Hexanediol occurs in diluted form, so professionals and consumers
exposure level will be very low.

Environment
1,6-Hexanediol is solid at room temperature and it has low volatility in liquid form above its boiling point.
Therefore, the probability of release in pure form to any of the environmental compartments is low, undernormal industrial use conditions. There may be some release to waste water streams as a result of normal use
or industrial cleaning operations. Due to its readily biodegradability, 1,6-Hexanediol should not cause further
environmental exposure.

RISK MANAGEMENT RECOMMENDATIONS
1,6-Hexanediol poses very low human health and environmental risks. However it is a good practice to train
personnel handling the substance and to protect workers who may be exposed to 1,6-Hexanediol by taking theusual precautionary measures to protect against chemical exposure. Therefore, protective clothing, gloves andsafety glasses with side shields should be worn when handling 1,6-Hexanediol. Good ventilation is required inareas where 1,6-Hexanediol is handled. Respiratory protection is not required unless 1,6-Hexanediol isreleased in the form of gas or in the form of aerosols. 1,6-Hexanediol is not flammable; however, it is goodpractice to prevent the build-up of electrostatic charge when storing it.
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
1,6-Hexanediol is included in the OECD list of High Production Volume (HPV) chemicals.
1,6-Hexanediol is listed in the following Chemical Inventories:_ TSCA, EINECS, ENCS, AICS, Canadian DSL,KECI, PICCS, IECSC, and NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.

Labeling according to REGULATION (EC) No 1272/2008:4

1,6-Hexanediol
August 12, 2012
Version: 1
Pictogram: none
Signal word: none
Hazard statements: none

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company: UBE Industries, Ltd.
Department: Fine Chemicals Business Unit
Address: Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo
Town/Country: Japan
Postal code: 105-8449
E-mail: ube-fine@ube-ind.co.jp

Additional information can be found at:
http://www.ube.co.jp

GLOSSARY
Acute toxicity

Harmful effect resulting from a single or short term exposure to asubstance.

AICS

Australian Inventory of Chemical Substances.

Biodegradation

Decomposition or breakdown of a substance under natural
conditions (actions of micro-organisms etc).

Bioaccumulation

Progressive accumulation in living organisms of a chemical
substance present in the environment.

Canadian DSL

Domestic Substances List of Canada.

Carcinogenicity

Substance effects causing cancer.

CASChemical Abstracts Service (division of the American ChemicalSociety).

Chronic toxicity

Harmful effect after repeated exposures or long term exposure to asubstance.

EINECS

European Inventory of Existing Commercial Chemical Substances

ENCS

Existing Notified Chemical Substances (Japan).

Flash point

The lowest temperature at which vapor of the substance may form
an ignitable mixture with air.

Genotoxicity

Substance effect that causes damage to genes, including
mutagenicity and clastogenicity.

GHS

Globally Harmonized System of Classification and Labeling of51,6-Hexanediol
August 12, 2012
Version: 1Chemicals
HPV

High Production Volume Chemicals.

Hydrolyze

Undergo hydrolysis; decompose by reacting with water.

IECSC

Inventory of Existing Chemical Substances Produced or Importedin China.

Intermediate

Substance that is manufactured for and consumed in or used forchemical processing in order to be transformed into anothersubstance.

KECI

Korean Existing Chemical Inventory.

Monomer

Means a substance which is capable of forming covalent bonds
with a sequence of additional like or unlike molecules under theconditions of the relevant polymer-forming reaction used for theparticular process.

Mutagenicity

Substance effect that cause mutation on genes.

NZIoC

New Zealand Inventory of Chemicals

PBT

Persistent, bioaccumulative, toxic chemical.

Persistence

Refers to the length of time a compound stays in the environment,
once introduced.

PICCS

Philippine Inventory of Chemicals and Chemical Substances.

Risk Management Measures

Engineering controls, conditions and protective equipment needed
to be implemented to ensure that the risks to human health and theenvironment are adequately controlled.

REACH (EC) No. 1907/2006

European Commission Regulation concerning the Registration,
Evaluation, Authorization and Restriction of Chemicals.

REGULATION (EC) No 1272/2008

European Commission Regulation on Classification, Labeling andPackaging of Substances and Mixtures.

Reproductive toxicity

Including teratogenicity, embryotoxicity and harmful effects onfertility.

Sensitizing

Allergenic.

Sediment

Topsoil, sand and minerals washed from land into water forming in
the end a layer at the bottom of rivers and sea.

TSCA

Toxic Substance Control Act (USA).

Vapor pressure

A measure of a substance’s property to evaporate.

vPvB

Very persistent, very bio-accumulative.

DISCLAIMER6

1,6-Hexanediol
August 12, 2012
Version: 1
This information is furnished without warranty, expressed or implied, except that it is accurate to the best
knowledge of UBE INDUSTRIES, LTD. The data on this sheet related only the specific material designatedherein. UBE INDUSTRIES, LTD. assumes no legal responsibility for use or reliance upon these data.

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