Curriculum Vitae
Yasuaki Kimura
Associate Professor
Nagoya University, Department of Chemistry, Graduate School of Science
Tel: +81‐(0)52‐789‐2950
Fax: +81‐(0)52‐789‐2491
Email: y‐kimura[at]chem.nagoya‐u.ac.jp

Education/Career

2008/3

B.Sc

Department of Pharmaceutical Sciences

The University of Tokyo (Prof. Masakatsu Shibasaki)
2010/3

M.Sc

Graduate School of Pharmaceutical Sciences

The University of Tokyo (Prof. Masakatsu Shibasaki)
2013/3

Ph.D (Pharmaceutical Sciences)
Graduate School of Pharmaceutical Sciences
The University of Tokyo (Prof. Motomu Kanai)

2013/4 – 2015/6

ERATO Project Researcher
ERATO Kanai Life‐Science Catalysis ProjectGraduate School of Pharmaceutical Sciences
The University of Tokyo (Prof. Motomu Kanai)

2015/4 – 2015/6

Specially Appointed Assistant Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo (Prof. Motomu Kanai)

2015/7– 2020/6

Assistant Professor
Graduate School of Science, Department of Chemistry
Nagoya University (Prof. Hiroshi Abe)

2017/6– 2020/6

Assistant Professor
Institute for Advanced Research, Nagoya University

2020/7– 2022/5

Lecturer
Graduate School of Science, Department of Chemistry
Nagoya University (Prof. Hiroshi Abe)

2022/6– PresentAssociate Professor
Graduate School of Science, Department of Chemistry
Nagoya University (Prof. Hiroshi Abe)

Fellowships

2010/4 – 2013/3

Research Fellow of the Japan Society for the Promotion of Sciences (DC1)2019 – 2020

Toyota Riken Scholar (Toyota Physical and Chemical Research Institute)Memberships
The Pharmaceutical Society of JapanThe Chemical Society of Japan
Japan Society of Nucleic Acids Chemistry
The Japanese Society for Chemical Biology
The Society of Synthetic Organic Chemistry of Japan

Awards
Elected Member of the Otsu Conference 2011 (since 2010 to present)2018 Ohtsuka Awards(ISNAC Outstanding Oral Presentation Award for Young Scientist)Publication List

1.

Abe, N.; Imaeda, A.; Inagaki, M.; Li, Z.; Kawaguchi, D.; Onda, K.; Nakashima, Y.;
Uchida, S.; Hashiya, F.; Kimura, Y.; Abe, H.
“Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical
Capping Reaction.”ACS Chem. Biol. 2022., 17 , 1308–1314.

2.

Yoshida, Y.; Zheng, T.; Tanabe, W.; Tomoike, F.; Hashiya, F.; Suzuki, T.; Hirota, S.;
Saiki, Y.; Horii, A.; Hirayama, A.; Soga, T.; Kimura, Y.; Abe, H.
“Development of Fluorophosphoramidate as a Biocompatibly Transformable
Functional Group and its Application as a Phosphate Prodrug for NucleosideAnalogs.”
ChemMedChem 2022, e202200188, in press.
3.

Yoshida, Y.; Honma, M.; Kimura, Y.; Abe, H.
“Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1
Reverse Transcriptase Inhibitors (NRTIs).”
ChemMedChem 2021, 16, 743‐766.

4.

Yamaoka, K.; Oikawa, R.; Abe, N.; Nakamoto, K.; Tomoike, F.; Hashiya, F.; Kimura, Y.;
Abe, H., Completely“Chemically Synthesized Long DNA Can be Transcribed in Human Cells.”
ChemBioChem 2021, 22, 3273‐3276.

5.

Hiraoka, H.; Shu, Z.; Tri Le, B.; Masuda, K.; Nakamoto, K.; Fangjie, L.; Abe, N.;
Hashiya, F.; Kimura, Y.; Shimizu, Y.; Veedu, R. N.; Abe, H.
“Antisense Oligonucleotide Modified with Disulfide Units Induces Efficient Exon
Skipping in mdx Myotubes through Enhanced Membrane Permeability and Nucleus
Internalization. “
ChemBioChem 2021, 22, 3437‐3442.

6.

Kawaguchi, D.; Kodama, A.; Abe, N.; Takebuchi, K.; Hashiya, F.; Tomoike, F.;
Nakamoto, K.; Kimura, Y.; Shimizu, Y.; Abe, H.
“Phosphorothioate Modification of mRNA Accelerates the Rate of Translation
Initiation to Provide More Efficient Protein Synthesis.“Angew. Chem. Int. Ed., 2020, 59, 17403.

7.

Fujita, H.; Oikawa, R.; Hayakawa, M.; Tomoike, F.; Kimura, Y.; Okuno, H.; Hatashita,Y.; Fiallos Oliveros, C.; Bito, H.; Ohshima, T.; Tsuneda, S.; Abe, H.; Inoue, T.
“Quantification of native mRNA dynamics in living neurons using fluorescencecorrelation spectroscopy and reduction‐triggered fluorescent probes.”
Journal of Biological Chemistry, 2020, 295, 7923‐7940.

8.

Nakamoto, K.; Abe, N.; Tsuji, G.; Kimura, Y.; Tomoike, F.; Shimizu, Y.; Abe, H.
“Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling
circle translation.”
Chemical Communications, 2020, 56, 6217‐6220.

9.

Nguyen H. N; Suzuki K.; Kimura Y.; Hirokawa T.; Murakami‐Tonami Y.; Abe H.
“Synthesis and biological evaluation of NMDI 14 derivatives as anti‐mesothelioma
agents” Heterocycles, 2020, 100, 253.

10. Shu Z., Ota A., Takayama Y., Katsurada Y.; Kusamori K., Abe N., Nakamoto K.,
Tomoike F., Tada S.; Ito Y., Nishikawa M., Kimura Y.; Abe H.
“Intracellular delivery of Antisense DNA and siRNA with amino groups masked withdisulfide units”
Chemical and Pharmaceutical Bulletin, 2020, 68, 129.
11. Kimura, Y.; Shu, Z.; Ito, M.; Abe, N.; Nakamoto, K.; Tomoike, F.; Shuto, S.; Ito, Y.; Abe,H.
“Intracellular build‐up RNAi with single‐strand circular RNAs as siRNA precursors”
Chemical Communications, 2020, 56, 466.
12. Tian, S.; Terai, G.; Kobayashi, Y.; Kimura, Y.; Abe, H.; Asai, K.; Ui‐Tei, K.
“A robust model for quantitative prediction of the silencing efficacy of wild‐type andA‐to‐I edited miRNAs”
RNA Biology, 2020, 17, 264.
13. Kawaguchi, D.; Shimizu, S.; Abe, N.; Hashiya, F.; Tomoike, F.; Kimura, Y.; Abe, H.
“Translational control by secondary‐structure formation in mRNA in a eukaryoticsystem” Nucleosides, Nucleotides & Nucleic Acids, 2020, 39, 195‐203.
14. Imaeda, A.; Tomoike, F.; Hayakawa, M.; Nakamoto, K.; Kimura, Y.; Abe, N.; Abe, H.
“N6‐methyl adenosine in siRNA evades immune response without reducing RNAiactivity” Nucleosides, Nucleotides & Nucleic Acids, 2019, 38, 972.
15. Shu, Z.; Tanaka, I.; Ota, A.; Fushihara, D.; Abe, N.; Kawaguchi, S.; Nakamoto, K.;
Tomoike, F.; Tada, S.; Ito, Y.; Kimura, Y.; Abe, H.
“Disulfide‐unit conjugation enables ultrafast cytosolic internalization of antisense
DNA and siRNA”
Angewandte Chemie International Edition, 2019, 58, 6611‐6615.
16. Shishido, Y.; Tomoike, F.; Kuwata, K.; Fujikawa, H.; Sekido, Y.; Murakami‐Tonami, Y.;

Kameda, T.; Abe, N.; Kimura, Y.; Shuto, S.; Abe, H.
“A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells. “
ChemBioChem, 2019, 20, 900.
17. Abe, H. Kimura, Y.
“Chemical Ligation Reactions of Oligonucleotides for Biological and MedicinalApplications”
Chemical and Pharmaceutical Bulletin, 2018, 66, 117.
18. Maruyama, H.; Oikawa, R.; Hayakawa, M.; Takamori, S.; Kimura, Y; Abe, N.; Tsuji, G.;
Matsuda, A.; Shuto, S.; Ito, Y.; Abe, H.
“Chemical ligation of oligonucleotides using an electrophilic phosphorothioester”
Nucleic Acids Research, 2017, 45, 7042.
19. Shishido, Y.; Tomoike, F.; Kimura, Y.; Kuwata, K.; Yano, T.; Fukui, K.; Fujikawa, H.;
Sekido, Y.; Murakami‐Tonami, Y.; Kameda, T.; Shuto, S.; Abe, H.
“A covalent G‐site inhibitor for glutathione S‐transferase Pi (GSTP1‐1)”
Chemical Communications, 2017, 53, 11138.
20. Kimura, Y.; Saito, N.; Hanada, K.; Liu, J.; Okabe, T.; Kawashima, S. A.; Yamatsugu, K.;
Kanai, M.
“Supramolecular Ligands for Histone Tails by Employing a Multivalent Display ofTrisulfonated Calix[4]arenes”
ChemBioChem, 2015, 16 (18), 2599.
21. Kimura, Y.; Ito, S.; Shimizu, Y.; Kanai, M.
“Catalytic Anomeric Aminoalkynylation of Unprotected Aldoses”
Org. Lett. 2013, 15, 4130.
22. Kimura, Y.; Yamatsugu, K.; Kanai, M.; Echigo, N.; Kuzuhara, T.; Shibasaki, M.
“Design and Synthesis of Resin‐Conjugated Tamiflu Analogs for Affinity
Chromatography”
Bull. Korean. Chem. Soc. 2010, 31, 588. (dedication issue to Professor Sunggak Kim).
23. Hiasa, M.; Isoda, Y.; Kishimoto, Y.; Saitoh, K.; Kimura, Y.; Kanai, M.; Shibasaki, M.;
Hatakeyama, D.; Kirino, Y.; Kuzuhara, T.

“Inhibition of MAO‐A and stimulation of behavioural activities in mice by the inactive
prodrug form of the anti‐influenza agent oseltamivir”
British J. Pharmacology 2013, 169, 115.
24. Kimura, Y.; Yamatsugu, K.; Kanai, M.; Echigo, N.; Kuzuhara, T.; Shibasaki, M.
“Design and synthesis of immobilized Tamiflu analog on resin for affinity
chromatography”
Tetrahedron Lett. 2009, 50, 3205. (50 th Anniversary Special Issue)
25. Morita, M.; Drouin, L.; Motoki, R.; Kimura, Y.; Fujimori, I.; Kanai, M.; Shibasaki, M.
“Two Methods for Catalytic Generation of Reactive Enolates Promoted by a Chiral
Poly Gd Complex: Application to Catalytic Enantioselective Protonation Reactions”
J. Am. Chem. Soc. 2009, 131, 3858. (featured by Synfacts 2009, 626.)
26. Yamatsugu, K.; Yin, L.; Kamijo, S.; Kimura, Y.; Kanai, M.; Shibasaki, M.
“A synthesis of Tamiflu based on a barium‐catalyzed Diels‐Alder‐type reaction”
Angew. Chem. Int. Ed. 2009, 48, 1070. (featured by Synfacts 2009, 702.)
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