Safety Summary Sheet
1,3-bis (aminomethyl) benzene （CAS NO. 1477-55-0）
SPECIES

1,3-bis (aminomethyl) benzene

PROTOCOL

RESULTS（CAS NO.: 1477-55-0）
PHYSICAL-CHEMICAL
2.1

Melting Point

Unknown

14.1 ℃

2.2

Boiling Point

Unknown

273 ℃ [1013hPa]

2.3

Density

2.4

Other: pycnometer

Vapour Pressure

1.052 [20℃]

Unknown

1.0502 [20 ℃ reference temperature
4℃]

Unknown

20 hPa [145℃]

Unknown(Calculation)

0.04 hPa [25℃]

2.5

Partition Coefficient(log Kow)

OECD TG 107

LogPow : ca.0.18 [25℃]2.6.1A

Water Solubility

OECD TG 105> 100000 mg/L [25℃]

2.6.1.B

Dissociation Constant（pKa）

OECD TG 112

pKa : ca.9.19 [25℃]

ENVIRONMENTAL FATE AND PATHWAY
3.1.1

Photodegradation

Calculation by
EUSES v.1.00
AOPWIN rate
constant

Half-life : 5.39 hrs [OH concentration
5×1011 molecules/m3]

3.1.2

Stability in Water

OECD TG 111

Stable at pH 4, 7 and 9 [50℃]

3.1.3

Stability in Soil

No data

3.2

Monitoring Data

No data

3.3.1

Transport between
Environmental Compartments

CalculationbyFugacity Level IIImodel(100% to air)
air : 0.215%
Water : 38.576%
Soil : 61.121%
Sediment : 0.088%(100% to water)
air : 4×10-5%
Water : 99.760%
Soil : 0.012%
Sediment : 0.228%(100% to soil)
air : 0.005%
Water : 36.138%
Soil : 63.775%
Sediment : 0.082%

3.3.2

Distribution

3.4

Biodegradation

No data(Koc etc.）
activated sludge,
non-adaptedOECD TG 301B
and
92/69/EEC
Method C.4-C

Not readily biodegradable (49% after
28 days)activated sludge,
non-adaptedOECD TG 302C
(ModifiedNot inherently biodegradable(Analysis by HPLC: 21%, BOD :1

1,3-bis (aminomethyl) benzene

SPECIESPROTOCOL

RESULTS（CAS NO.: 1477-55-0）
MITI(2))

3.5

BOD-5, COD or BOD-5／
COD ratio

3.6

Bioaccumulation

22%, TOC : 6% after 28 days)

No data
Cyprinus carpio

OECD TG 305

BCF < 2.7

Oryzias latipes

OECD TG 203

LC50 (96 h) : 87.6 mg/L

Leuciscus idus

OECD TG 203

LC50 (96 h) : 75 mg/L

ECOTOXICOLOGY
4.1

Acute Toxicity to Fish

4.2

Acute Toxicity to Aquatic
Invertebrates (Daphnia etc.)

Daphnia magna

OECD TG 202

EC50 (48 h) : 15.2 mg/L

4.3Toxicity to Aquatic Plants(Algae etc.)

Selenastrum
capricornutum

OECD TG 201

EbC50 (0-72h) : 20.3 mg/L
NOECb (0-72h) : 10.5 mg/L

Scenedesmus

OECD TG 201

EbC50 (0-72h) : 12 mg/L
NOECb(0-72h) : 6.25 mg/L

ISO 10712 andBewertung
Wassergefahorden
der Stoffe
LTWS-Nr10

EC50 (16 h) : 130 mg/L

subspicatus
4.4

Toxicity to Microorganisms(Activated Sludge Respiration
Inhibition test etc.)

Pseudomonas
putida4.5.1

Chronic Toxicity to Fish

4.5.2

Chronic Toxicity to Aquatic
Invertebrates4.6Toxicity to TerrestrialOrganisms

No data

4.6.1

Toxicity to Sediment DwellingOrganisms

No dataDaphnia magna

OECD TG 211

No data
NOEC (21 d) : 4.7 mg/L
(Reproduction)
LOEC (21 d) : 15 mg/L (Parentaldaphnia)

TOXICOLOGY
5.1

Toxicokinetics, Metabolism
and Distribution

5.2

Acute Toxicity

No dataA.

Acute Oral Toxicity

Rat

OECD TG 401

LD50 :
male ; 1090 mg/kg
female ; 980 mg/kg

B.

Acute Inhalation Toxicity

Rat

84/449/EEC, B.2
similar to OECD
TG 403

LC50 :
male ; > 1.42 mg/L
female ; 0.8 mg/L

C.

Acute Dermal Toxicity

No dataD.

Acute Toxicity, Other Routes

No data

5.3
A.

Irritation/Corrosion
Skin Irritation/Corrosion

Rat

Similar to84/449/EEC B.4

2Corrosive

1,3-bis (aminomethyl) benzene

SPECIESPROTOCOL

RESULTS（CAS NO.: 1477-55-0）
B.

Eye Irritation/Corrosion

No data

5.4

Skin Sensitization

Guinea pig

92/69/EEC, B.6
Maximization test

sensitizing

5.5

Repeated Dose Toxicity

Rat

CSCL of Japan*(oral gavage, 28days)

NOEL : 150 mg/kg/day

RatOECD TG 421(oral gavage)

NOAEL : 50 mg/kg/day

5.6

Genetic Toxicity in vitro

A.

Gene Mutation(Bacterial Test etc.)

S. typhimurium
and E. coli

CSCL of Japan*

Negative

B.

Chromosomal Aberration

CHO cellsOECD 473
67/548/EEC, B10
EPA (TSCA,FIFRA),§798.537
5Negative

5.7

Genetic Toxicity in vivo

Mouse

OECE TG 474（oral gavage,Micronucleus
assay）

Negative

5.8

Carcinogenicity

5.9

Toxicity to Reproduction

A.

Toxicity to Fertility

B.

Developmental
Toxicity/Teratogenicity

5.10

Other relevant information

5.11

Experience with HumanExposure

No dataRat

OECD TG 421(oral gavage)

NOEL :Parental
male ; 50 mg/kg/day
female ; 150 mg/kg/day
Pups ; 450 mg/kg/day
Reproductive ; 450 mg/kg/day
See 5.9 A.
No dataWorkers
exposed toepoxy resin
containing
1,3-bis(aminomethyl)
benzenePatch test

Incidence rate of allergic contact
dermatitis (ACD) was 4.5/1000、and
positive reaction in patch test was seen
in 40% of tested workers with ACD* : Testing guidelines for Japanese Chemical Substances Control Law

Contact : http://www.sumitomo-chem.co.jp/english/contact/

IMPORTANT: While the data and information compiled herein are presented in good faith andbelieved to be accurate or valuable, it is provided for your reference only. It is expressly or
implicitly understood that Sumitomo Chemical makes no warranty or assumes no liability or
obligation for the data and information provided.

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