GPS/JIPS Safety Summary Reference No.：1002

GPS/JIPS Safety Summary
1. SUBSTANCE NAME
β-Alanine (CAS No.107-95-9)
2. GENERAL STATEMENT
β-Alanine is an odourless white crystalline powder. In general, β-alanine is used as a rawmaterial for pharmaceuticals and a buffer material. β-Alanine of YUKI GOSEI KOGYO
CO., LTD. is used as raw materials for calcium pantothenate, pharmaceuticals,surfactants and supplements.
β-Alanine is an amino acid which does not constitute protein. β-Alanine is a componentof the naturally occurring peptides carnosine and anserine and also of pantothenic acid(vitamin B5) and is formed in vivo by the degradation of dihydrouracil and carnosine. No
particular problems regarding safety have been found so far in the use of β-alanine invarious fields.
Worker exposure to β-alanine via dermal and inhalation routes is expected in industrial
uses during manufacturing of β-alanine or uses of β-alanine as an intermediate.
Therefore, it is recommended to use a closed system, machine or local exhaust
ventilation system to ensure adequate ventilation as well as providing appropriate
personal protective equipments (e.g. safety goggles, respiratory protection such asmasks, gloves) in order to minimize exposure.
When consumers use products containing β-alanine, be sure to use the products inaccordance with the instruction manuals attached. Emissisons to the environment isexpected during industrial uses such as manufacturing of β-alanine or uses of β-alanine
as an intermediate. Therefore, it is recommended to take measures to prevent leakage
and to install waste water treatment equipment and carry out periodic maintenance ofequipment in order to minimize the impact on environmental organisms.
3. CHEMICAL IDENTITY
General nameBrand nameChemical name
CAS number
Other identical numbers
Molecular formulaβ-Alanineβ-Alanineβ-Aminopropionic acid107-95-9EC number: 203-536-5
MITI Number: (9)-1554 (CSCL1), ISHA2))
H2NCH2CH2COOH

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Structural formula

Other information
References

Not specified
NikkajiWeb
NITE Chemical Risk Information Platform (NITE-CHRIP)

1) Chemical Substances Control Law in Japan
2) Industrial Safety and Health Act in Japan

4. USES AND APPLICATIONS
Main uses

β-Alanine of YUKI GOSEI KOGYO CO., LTD. is used as raw
materials for calcium pantothenate, pharmaceuticals,surfactants and supplements.

5. PHYSICAL/CHEMICAL PROPERTIES
Property
Form (physical state)
ColourOdour
Relative density
Melting point / Freezing point
Flammability
Flash point
Explosive properties
Autoflammability / self-ignition
temperature
Vapour pressure
Molecular Weight
Water solubility
Partition coefficient n-octanol / water
Reference

Value

Crystalline powder (20°C, 1013 hPa)WhiteOdourless
1.437 g/cm3 (19°C)
Melting point: 197 - 198°C (Dec.)
Not highly flammableNot applicable
Non explosive
Not to have a relative self-ignition temperature
below its melting temperature
0.00000674 Pa (25°C)
89.09
40% (20°C)
log Kow = -3.05
Chemical Safety Report, Safety Data Sheet

6. HEALTH EFFECTS
Effect Assessment
Acute toxicity
Skin corrosion / irritation
Serious damage / eye irritation

ResultNo adverse effect observed for oral routeNo adverse effect observed (not irritating)No adverse effect observed (not irritating)
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Respiration sensitization
Skin sensitization
Genetic toxicity
Carcinogenicity
Reproductive toxicity

No study available

No adverse effect observed (not sensitizing)No adverse effect observed (negative)
No study available
No adverse effect observed in a reproductive /developmental toxicity screening test
No adverse effect observed for oral route
Chemical Safety Report

Repeated dose toxicity
Reference
7. ENVIRONMENTAL EFFECTS

Effect Assessment
Aquatic Toxicity
No hazard identified
Hazardous to the ozone No hazard identified
layer
Reference
Chemical Safety Report

ResultFate and behaviour
Mobility in environment

Result

Biodegradation
Bioaccumulation
potentialPBT/vPvB conclusion
Reference・Potential for adsorption to organic soil is low on the basis of
the estimated Koc of 0.02798.
・Evaporation from the water surface into the atmosphere is
not to be expected on the basis of the estimated Henry’s
Law constant H of 0.00000758 Pa・m3/mol at 25°C.
A screening test according to OECD test guideline resulted
in readily biodegradable.
Model calculations confirm no bioaccumulation potential for
β-Alanine
Not a PBT / vPvB substanceChemical Safety Report

8. EXPOSURE
SubjectWorker
exposureConsumerexposure

Exposure potential for main uses of our products(Route of exposure)
Worker exposure to β-alanine via dermal and inhalation routes isexpected in industrial uses during manufacturing of β-alanine or usesof β-alanine as intermediate.
PROC3: Manufacture or formulation in the chemical industry inclosed batch processes with occasional controlled exposure orprocesses with equivalent containment condition
Consumer exposure via oral route is expected as β-alanine is used asa raw material for supplements.
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Environmentalexposure

Emissison to the environment is expected during industrial uses suchas manufacturing of β-alanine or uses of β-alanine as intermediates.

9. RISK MANAGEMENT RECOMMENDATIONS
Subject
WorkerexposureConsumer
exposure
Environmental
exposure

Remarks
Notes

Recommended Risk Management Measures- Use a closed system, machine or local exhaust ventilation system toensure adequate ventilation in order to minimize exposure.
- Take measures to prevent dust generation. In the case of dust
generation, consider to use dust protection mask or powered airpurifying respirator as well as simple dust mask.
- Use appropriate personal protective equipments (e.g. safety
goggles, respiratory protection such as masks, gloves) and be sureto have an eyewash and shower equipment near the handling area.
- Workplace managers ensure to train and educate workers on theselection and use of appropriate protective equipments and the wayof maitaining workplace safety.
- Use the products in accordance with the instruction manuals
attached.
- Take measures to prevent leakage and to install waste water
treatment equipment and carry out periodic maintenance ofequipment in order to minimize the impact on environmentalorganisms.
- Prevent residues of β-alanine from entering rivers, surface water
channel or drains.
NoneNone

10. SUBSTANCE REVIEW INFORMATION
Review Program
International
Chemical
Safety Cards (ICSC)OECD High Production
Volume Chemicals (HPVChemicals)
OthersJapan HPV Challenge
Program

Review status－－Final Report is available from:http://www.safe.nite.go.jp/jcheck/detail.action?cno=107-959&mno=9-1554&request_locale=ja

11 Regulatory information / GHS classification and labelling information
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Regulatory information
Legislation
REACHChemical Substances Control
Law (CSCL) in Japan
Industrial Safety and Health
Act (ISHA) in Japan

Regulatory status
Registered Substancehttps://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/2084
Existing Chemical
Existing Chemical

GHS classification
Type of hazard
Physical hazard
Health hazard
Environmental hazard

Not classified
Not classified
Not classified

GHS labelling elements
Pictogram / symbol
Signal word
Hazard statement

Not applicableNot applicableNot applicable

Classification

12. CONTACT INFORMATION
Company name:
Address:
Department in charge:
Telephone /FAX numbers:

YUKI GOSEI KOGYO CO., LTD.
10-4, Nihongashi-Ningyocho 3-Chome, Chuo-ku 103-0013
Tokyo, Japan
Sales Division+81-3-3664-3982 / +81-3-3664-3991

13. DATE OF ISSUE / REVISION DATE / OTHER INFORMATION
Date of issue: December 3, 2018
Revision history:Revision date

Sectionchanges

Other information: None
14. DISCLAIMER

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VersionGPS/JIPS Safety Summary Reference No.：1002

This GPS safety summary is intended to provide information on chemical products as abrief summary in line with GPS (Global Product Strategy) of the chemical industry. It does
not provide expert information such as risk assessment procedures and/or effects onhuman health and the environment. It is not intended to replace Safety Data Sheet (SDS)
or Chemical Safety Report (CSR). The information provided is based on the regulations,materials and information available at the date of its publication, however, it provides nowarranty or representation regarding the content. In addition, it is not intended to specify
the quality of the product.

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