Safety Summary Sheet
1,3-Diphenylguanidine （CAS NO. 102-06-7）
SPECIES

1,3-Diphenylguanidine

PROTOCOL

RESULTS（CAS NO.: 102-06-7）
PHYSICAL-CHEMICAL
2.1

Melting Point

Differential
scanning
calorimetry

147～150℃

2.2

Boiling Point

Differential
scanning
calorimetry＞200℃（1.013×105 Pa）

2.3

DensityUnknown

1.13 g/cm3 (at 20℃)

2.4

Vapour Pressure

Extrapolationfrom measured
data at 87128℃

1.74×10-6 Pa

2.5

Partition Coefficient(log Kow)

Calculated data

2.9

2.6.1A

Water Solubility

Similar to OECD
TG 105475 mg/L (at 20℃, pH7)

2.6.1.B

Dissociation Constant（pKa）

Unknown

10.12

Aqueous solution(incl. 1%
acetonitrile)
exposed tosunlight for 7days

No photolysis observed in waterCalculation byAopWin v1.92

Photodegradation in air :T1/2 : 0.125day

At 80 ℃ , pH3.5,
7.0 and 10

pH3.5 : no hydrolysis after 500hrs
pH7.0 : hydrolysis of 18.1% after
1000hrs
pH10 : T1/2 ; 168hrs(at 20℃)

ENVIRONMENTAL FATE AND PATHWAY
3.1.1

Photodegradation

3.1.2

Stability in Water

3.1.3

Stability in Soil

3.2

Monitoring Data

Detail unknown(MOE of Japan
monitoring data,1978)<LOD both in surface water and insediment (42 samples)(LOD : 2-5μg/L for surface water,0.1-0.5mg/kg for sediment)

3.3.1

Transport between
Environmental Compartments

Calculation
byFugacity Level III
model (EPI WINver.3.12)

Air : 5.67×10-5 %Water : 13.3%
Soil : 86.5%
Sediment : 0.238%

3.3.2

Distribution

3.4

Biodegradation

No data(Koc etc.）

No data
Adaptedactivated sludge

1

Similar to OECD
TG 301D Closed

ca. 75% degraded after 28day(inherently biodegradable)1,3-Diphenylguanidine

SPECIESPROTOCOL

RESULTS（CAS NO.: 102-06-7）
bottle method
3.5

BOD-5, COD or BOD-5／
COD ratio

3.6

Bioaccumulation

Unknown

BOD-5 : 2.3% (referred to TOD）

Carp

OECD TG 305C

BCF <20

ECOTOXICOLOGY
4.1

Acute Toxicity to Fish

Fathead minnow

Static （US EPA
EcologicalResearch series
660/3-75009）

96hr LC50 : 4.2mg/L

4.2

Acute Toxicity to Aquatic
Invertebrates (Daphnia etc.)

Daphnia magna

Static （US EPA
EcologicalResearch series
660/3-75009）

48hr EC50 : 17 mg/L

4.3Toxicity to Aquatic Plants(Algae etc.)

Selenastrum
capricornutum

Static （USEPA , 1971, Algae
assay procedure:bottle test）

96hr EC50 : 1.7 mg/L
96hr NOEC : 0.3 mg/L

4.4

Toxicity to Microorganisms(Activated Sludge Respiration
Inhibition test etc.)

Activated sludge

OECD TG 209
Activated sludge,
respiration
inhibition test

3hr EC50 : 147 mg/L

4.5.1

Chronic Toxicity to Fish

4.5.2

Chronic Toxicity to Aquatic
Invertebrates

Daphnia magna

OECD TG 202(Part2)

21day NOEC : 0.6 mg/L

4.6Toxicity to Terrestrial
Organisms

Brassica rapa

BBA Guideline1984 (endpoint :growth)

16day EC50 : 358 mg/kg soil dw,
16day NOEC : 100 mg/kg soil dw

Soilmicroorganisms

Unknown(endpoint :mortality)

4day LC50 : <0.1%

Red winged
blackbirds,
Starlings andPasser
domesticus

Single oral
application(endpoint :mortality)

LC50 : >100 mg/kg

4.6.1

No data

No data

Toxicity to Sediment Dwelling
Organisms

TOXICOLOGY2

1,3-Diphenylguanidine

SPECIESPROTOCOL

RESULTS

Unknown

Immediately absorbed and distributed
after oral administration（CAS NO.: 102-06-7）
5.1

Toxicokinetics, Metabolismand Distribution

Rat

Within 24hr, 80% of dosing isexcreted in urine and feces
5.2

Acute Toxicity

A.

Acute Oral Toxicity

B.

Acute Inhalation Toxicity

C.

Acute Dermal Toxicity

D.

Acute Toxicity, Other Routes

5.3

Rat

OECD TG 401

LD50 :
male ; 111 mg/kg
female ; 107 mg/kg
No data

RabbitEEC NL251/103
part B3

LD0 : >2000 mg/kg
No data

Irritation/Corrosion

A.

Skin Irritation/Corrosion

RabbitSimilar to OECD
TG 404

Not irritating*1

B.

Eye Irritation/Corrosion

RabbitSimilar to OECD
TG 405

Corrosive*1

5.4

Skin Sensitization

Guinea pig

OECD TG 406(GPMT)

Not sensitizing

5.5

Repeated Dose Toxicity

Rat

OECD TG 408(90 day, oral feed)

NOAEL : 500 ppm(32 mg/kg/day)

5.6

Genetic Toxicity in vitro

A.

Gene Mutation(Bacterial Test etc.)

S. typhimurium
and E. coli

OECD TG 471

Negative

B.

Chromosomal Aberration

CHL/IUOECD TG 473

Negative

5.7

Genetic Toxicity in vivo

Rat

OECD TG 475
Chromosomal
Aberration assay(oral gavage)

Negative

Mouse

Micronucleus
assay(method byMcGregor et al.,oral feed)

Male ; Negative
Female ; Equivocal

5.8

Carcinogenicity

5.9Toxicity to Reproduction

A.

Toxicity to Fertility

B.

Developmental
Toxicity/Teratogenicity

5.10

Other relevant information

5.11

Experience with HumanExposure

No data

No data*2
Rat

EPA Health
Effecs Guidelines
560/6-82-001(oral gavage)

NOAEL :
Maternal ; 5 mg/kg/day
Fetal ; 25 mg/kg/day
Not teratogenic
No data

Human

Patch test

3sensitizing*1 : unpublished in-house data
*2 : 1,3-Diphenylguanidine did not affect the fertility of male mice when administered by gavage up to the maximal
tested dose level of 16 mg/kg/d.

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IMPORTANT: While the data and information compiled herein are presented in good faith andbelieved to be accurate or valuable, it is provided for your reference only. It is expressly or
implicitly understood that Sumitomo Chemical makes no warranty or assumes no liability orobligation for the data and information provided.

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