Arti cialIntelligence Report

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Concepts
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Concepts are topics or associations between topics andactions that represent the content of your paper. For
example, for a paper discussing the e ect of goodparenting on academic performance in children,concepts could be "good parenting", "children","academic performance".

Concept
Keywords

Expert’s comment - Concepts
These concepts accurately re ect thepaper content.

We could identify relevant concepts from
Ethical Complianceyour paper.

Technical ComplianceConcept
novel green process
selenium nanoparticles
nanoparticle fabrication processpulsed laser ablation in liquids
Laser Ablation
anticancer activity
surface purity limitation
Green Nanotechnology
Escherichia coli

Keywords
Keywords help readers in quickly gaining insight into thetopics discussed in the manuscript. Keywords included
should be representative of your research topic andshould not be generic terms such as "patient","retrospective".

We could not detect keywords in yourpaper.
We have suggested some keywords.
Suggested Keywords
selenium nanoparticles
Laser Ablation
anticancer activity
Green Nanotechnology
Escherichia coli

Expert’s comment - Keywords
These could be used as keywords as
they accurately re ect your paper
content.

Arti cialIntelligence Report

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Journals require authors to make several declarations
a rming that required ethical guidelines were followedin the conduct of the study. This is particularly importantin studies involving humans or animals.

Informed Consent
If your work involves humans, you should
include a statement con rming that
informed consent was obtained from allparticipants or whether the requirement of
informed consent was waived by theinstitutional review board.

Concept
KeywordsEthical Compliance

Ethical Compliance

Expert’s comment - InformedConsent
This is as per journal instructions.

 We detected informed consent
declaration in your paper.

Technical ComplianceThe patients were informed of theprocedures and provided theirconsent towards inclusion in thestudy.

Ethics Statement
If your work involves animals, you should
include a statement declaring you had
followed all applicable international,
national, and/or institutional guidelines forthe care and use of animals. If your work
involves human participants, you should
include a statement that all procedures
involving human participants were inaccordance with the ethical standards of theinstitutional and/or national researchcommittee.

Expert’s comment - Ethics
StatementThis is as per journal instructions.

 We detected ethical approval declaration
in your paper.

Ethical approval was obtained fromthe institutional ethical committee.
The institutional review board
approved this study after thoroughscrutiny of the procedures proposed.

Financial Disclosure
Most journals require you to declare all
sources of funding or nancial assistance.
You may also declare that the study did notreceive any nancial aid.

Expert’s comment - Financial
DisclosureThis is as per journal instructions.

 We detected nancial disclosures in yourpaper.

T. H. and P. T. would like to thank theMc Nair Research Program fornancial support.

Con ict of Interest
A con ict of interest is any relationship thatmay directly or indirectly in uence or bias
your research or its results. You must state
all con icts of interest or declare that there
are no con icts of interest.

Expert’s comment - Con ict ofInterest
This is as per journal instructions.

 We detected con ict of interest

Arti cialIntelligence Report

OverivewNo con icts of interest exist.
The authors do not have any
nancial associations con icting withthe publication.

Data Availability
Many journals now require the authors toinclude a 'Data availability' section in theirmanuscript. This section should provide
information on where the readers can obtain
the data required to reproduce the reported
results.

Concept
Keywords
Ethical Compliancedeclarations in your paper.

Expert’s comment - Data
Availability
This is as per journal instructions.

 We detected data availability declarations
in your paper.

Technical ComplianceFull data sets are available uponrequest.

Technical Compliance
The checks below help you meet standard publication
requirements that most journals have regarding yourmanuscript's readiness for editorial processing.

Manuscript Title
The journal may have speci c requirements
for the title, such as title length. Ensure thatyou meet all requirements.

Expert’s comment - Manuscript
title
I have suggested a title.

 We could not detect the title of yourpaper.

Authorship

Expert’s comment - Authorship

Authorship details include a liation,correspondence, and author contribution
details. These details help readers identifythe researcher group, their contact details,
and the contribution of each researcher tothe study.

The details are as per journalrequirements.

 We detected a liations in your paper.
1Department of Physics andAstronomy, University of Arkansas at
Little Rock,2 Department of ChemicalEngineering, Northeastern
University, 313 Snell Engineering
Center, 360 Huntington Avenue,
Boston, MA 02115, USA We detected correspondence details inyour paper.

xyz.xyz@abc.edu
xyz.xyz@abc.edu

 We detected author contribution
declaration in your paper.

â€ : Authors who contributed equallyto this workArti cialIntelligence Report

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Abstract

Expert’s comment - Abstract

An abstract presents the summary of thepaper to the reader. Most journals require
an abstract for most article types. Check thejournal instructions for the inclusion of theabstract, the type of abstract to be used, andthe word count limitation.

The abstract meets the journal
instructions.

 We detected an abstract in your paper of239 words.

Concept
Keywords
Ethical ComplianceTechnical Compliance

References

Expert’s comment - References

The bibliography or the references section
should contain details of all the works
referred to in your paper. This is necessary
to appropriately credit other authors' works
that you have referred to.

The references meet journal
instructions. I have made suggestions
for the references marked old.

 References were detected in your paper.
References
1.Pang, T.; Guindon, G. E.,
Globalization and risks to health.
EMBO Rep. 2004, 5 Spec No, S11-6.
Old reference

2. Prestinaci, F.; Pezzotti, P.; Pantosti,A., Antimicrobial resistance: a global
multifaceted phenomenon. Pathog.
Global Health 2015, 109 (7), 309-18.

3. Ventola, C. L., The antibioticresistance crisis: part 1: causes andthreats. P&T 2015, 40 (4), 277-83.

4. Ma, X.; Yu, H., Global burden ofcancer. Yale J. Biol. Med. 2006, 79 (34), 85-94.
Old reference

5. Thun, M. J.; DeLancey, J. O.;
Center, M. M.; Jemal, A.; Ward, E. M.,
The global burden of cancer:priorities for prevention.
Carcinogenesis 2010, 31 (1), 100-10.
Old reference

6. Devlin, E. J.; Denson, L. A.;
Whitford, H. S., Cancer Treatment
Side E ects: A Meta-analysis of theRelationship Between Response
Expectancies and Experience. J. Pain
Symptom Manage. 2017, 54 (2), 245258 e2.

7. Housman, G.; Byler, S.; Heerboth,S.; Lapinska, K.; Longacre, M.;
Snyder, N.; Sarkar, S., Drug
resistance in cancer: an overview.
Cancers 2014, 6 (3), 1769-92.

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8. Saini, R.; Saini, S.; Sharma, S.,
Nanotechnology: the future
medicine. J. Cutan. Aesthet. Surg.
2010, 3 (1), 32-3.
Old reference

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9. Feynman, R. P., There's plenty ofroom at the bottom [data storage]. J.
Microelectromech. Syst. 1992, 1 (1),60-66.

Concept

Old reference

Keywords
Ethical ComplianceTechnical Compliance

10. Guisbiers, G., Size-dependent
materials properties toward auniversal equation. Nanoscale Res.
Lett. 2010, 5 (7), 1132-6.
Old reference

11. Hulla, J. E.; Sahu, S. C.; Hayes, A.
W., Nanotechnology: History andfuture. Hum. Exp. Toxicol. 2015, 34(12), 1318-21.

12. Jeevanandam, J.; Barhoum, A.;
Chan, Y. S.; Dufresne, A.; Danquah,M. K., Review on nanoparticles andnanostructured materials: history,sources, toxicity and regulations.
Beilstein J. Nanotechnol. 2018, 9,1050-1074.

13. Salata, O., Applications ofnanoparticles in biology andmedicine. J. Nanobiotechnol. 2004, 2(1), 3.
Old reference

14. Abdal Dayem, A.; Hossain, M. K.;
Lee, S. B.; Kim, K.; Saha, S. K.; Yang,G. M.; Choi, H. Y.; Cho, S. G., The Roleof Reactive Oxygen Species (ROS) in
the Biological Activities of Metallic
Nanoparticles. Int. J. Mol. Sci. 2017,18 (1).

15. Manke, A.; Wang, L.; Rojanasakul,Y., Mechanisms of nanoparticleinduced oxidative stress and toxicity.
Biomed Res. Int. 2013, 2013, 942916.

16. Slavin, Y. N.; Asnis, J.; Hafeli, U.
O.; Bach, H., Metal nanoparticles:
understanding the mechanisms
behind antibacterial activity. J.
Nanobiotechnol. 2017, 15 (1), 65.

17. Guisbiers, G.; Wang, Q.;
Khachatryan, E.; Mimun, L. C.;
Mendoza-Cruz, R.; Larese-Casanova,P.; Webster, T. J.; Nash, K. L.,
Inhibition of E coli and S aureus

Arti cialIntelligence Report

Inhibition of E. coli and S. aureus
with selenium nanoparticles
synthesized by pulsed laser ablationin deionized water. Int. J. Nanomed.
2016, 11, 3731-6.

18. Lara, H. H.; Guisbiers, G.;
Mendoza, J.; Mimun, L. C.; Vincent, B.
A.; Lopez-Ribot, J. L.; Nash, K. L.,
Synergistic antifungal e ect ofchitosan-stabilized selenium
nanoparticles synthesized by pulsed
laser ablation in liquids against
Candida albicans bio lms. Int. J.
Nanomed. 2018, 13, 2697-2708.

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Concept
Keywords
Ethical ComplianceTechnical Compliance21. Makarov, V. V.; Love, A. J.;
Sinitsyna, O. V.; Makarova, S. S.;
Yaminsky, I. V.; Taliansky, M. E.;
Kalinina, N. O., "Green"
Nanotechnologies: Synthesis ofMetal Nanoparticles Using Plants.
Acta Naturae 2014, 6 (1), 35-44.

22. Li, J.; Li, Q.; Ma, X.; Tian, B.; Li, T.;
Yu, J.; Dai, S.; Weng, Y.; Hua, Y.,
Biosynthesis of gold nanoparticles
by the extreme bacterium
Deinococcus radiodurans and anevaluation of their antibacterialproperties. Int. J. Nanomed. 2016,11, 5931-5944.

23. Li, G.; He, D.; Qian, Y.; Guan, B.;
Gao, S.; Cui, Y.; Yokoyama, K.; Wang,L., Fungus-mediated green synthesisof silver nanoparticles using
Aspergillus terreus. Int. J. Mol. Sci.
2012, 13 (1), 466-76.

24. Philip, D., Honey mediated green
synthesis of gold nanoparticles.
Spectrochim. Acta, Part A 2009, 73(4), 650-3.
Old reference

25. de Barros, C. H. N.; Cruz, G. C. F.;
Mayrink, W.; Tasic, L., Bio-based
synthesis of silver nanoparticles
from orange waste: e ects ofdistinct biomolecule coatings onsize, morphology, and antimicrobialactivity. Nanotechnol., Sci. Appl.
2018, 11, 1-14.

26. Jain, S.; Hirst, D. G.; O'Sullivan, J.
M., Gold nanoparticles as novelagents for cancer therapy. Br. J.
Radiol. 2012, 85 (1010), 101-13.

27. Le Ouay, B.; Stellacci, F.,
Antibacterial activity of silver
nanoparticles: A surface science
insight. Nano Today 2015, 10 (3),339-354.

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28. Salas-Orozco, M.; Niño-Martínez,N.; Martínez-Castañón, G.-A.;
Méndez, F. T.; Jasso, M. E. C.; Ruiz, F.,
Mechanisms of Resistance to Silver
Nanoparticles in Endodontic
Bacteria: A Literature Review. J.
Nanomater. 2019, 2019, 1-11.

29. Hurd, A. J.; Kelley, R. L.; Eggert, R.
G.; Lee, M.-H., Energy-criticalelements for sustainable
development. MRS Bull. 2012, 37 (4),405-410.

Concept
Keywords
Ethical ComplianceTechnical Compliance

30. Guan, B.; Yan, R.; Li, R.; Zhang, X.,
Selenium as a pleiotropic agent for
medical discovery and drug delivery.
Int. J. Nanomed. 2018, 13, 74737490.

31. Skalickova, S.; Milosavljevic, V.;Cihalova, K.; Horky, P.; Richtera, L.;
Adam, V., Selenium nanoparticles as
a nutritional supplement. Nutrition
2017, 33, 83-90.

32. Tan, V. L. C.; Hinchman, A.;
Williams, R.; Tran, P. A.; Fox, K.,
Nanostructured biomedical
selenium at the biological interface(Review). Biointerphases 2018, 13(6), 06D301.

33. Weekley, C. M.; Harris, H. H.,
Which form is that? The importanceof selenium speciation andmetabolism in the prevention andtreatment of disease. Chem. Soc.
Rev. 2013, 42 (23), 8870-94.

34. Hosnedlova, B.; Kepinska, M.;
Skalickova, S.; Fernandez, C.;
Ruttkay-Nedecky, B.; Peng, Q.;
Baron, M.; Melcova, M.; Opatrilova,R.; Zidkova, J.; Bjorklund, G.; Sochor,J.; Kizek, R., Nano-selenium and its
nanomedicine applications: a criticalreview. Int. J. Nanomed. 2018, 13,2107-2128.

35. Ferhati, H.; Dje al, F.; Arar, D.,
Above 14% e ciency earthabundant selenium solar cells byintroducing gold nanoparticles andTitanium sub-layer. Optical Materials
2018, 86, 24-31.

36. Kusper, M.; Guisbiers, G.,
Synthesis of aluminum oxide
nanoparticles by laser ablation inliquids. MRS Adv. 2018, 3 (64), 38993903.

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37. Bhattacharjee, S., DLS and zeta
potential - What they are and what
they are not? J. Controlled Release2016, 235, 337-351.

38. Guisbiers, G.; Wang, Q.;
Khachatryan, E.; Arellano-Jimenez,M. J.; Webster, T. J.; Larese-Casanova,P.; Nash, K. L., Anti-bacterial
selenium nanoparticles produced by
UV/VIS/NIR pulsed nanosecond laser
ablation in liquids. Laser Phys. Lett.
2015, 12 (1).

OverivewConcept
Keywords
Ethical ComplianceTechnical Compliance

39. Kuzmin, P. G.; Shafeev, G. A.;
Voronov, V. V.; Raspopov, R. V.;
Arianova, E. A.; Trushina, E. N.;
Gmoshinskii, I. V.; Khotimchenko, S.
A., Bioavailable nanoparticles
obtained in laser ablation of aselenium target in water. Quantum
Electron. 2012, 42 (11), 1042-1044.

40. Singh, S. C.; Mishra, S. K.;
Srivastava, R. K.; Gopal, R., Optical
Properties of Selenium Quantum
Dots Produced with Laser Irradiationof Water Suspended Se
Nanoparticles. J. Phys. Chem. C
2010, 114 (41), 17374-17384.
Old reference

41. Van Overschelde, O.; Guisbiers,G., Photo-fragmentation of selenium
powder by Excimer laser ablation inliquids. Opt. Laser Technol. 2015, 73,156-161.

42. Lucovsky, G.; Mooradian, A.;
Taylor, W.; Wright, G. B.; Keezer, R.
C., Identi cation of the fundamental
vibrational modes of trigonal, α monoclinic and amorphousselenium. Solid State Commun.
1967, 5 (2), 113-117.
Old reference

43. Anderson, A.; Sanders, A.; Smith,W., Raman spectra of selenium
dioxide at low temperatures. J.
Raman Spectrosc. 2000, 31 (5), 403406.
Old reference

44. Pecora, R., Dynamic Light
Scattering Measurement ofNanometer Particles in Liquids. J.
Nanopart. Res. 2000, 2 (2), 123-131.
Old reference

45. Cremonini, E.; Zonaro, E.; Donini,
M ; Lampis S ; Boaretti M ; Dusi S ;Arti cialIntelligence Report

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M.; Lampis, S.; Boaretti, M.; Dusi, S.;
Melotti, P.; Lleo, M. M.; Vallini, G.,
Biogenic selenium nanoparticles:characterization, antimicrobialactivity and e ects on humandendritic cells and broblasts.
Microb. Biotechnol. 2016, 9 (6), 758771.

46. Boroumand, S.; Safari, M.;
Shaabani, E.; Shirza, M.; FaridiMajidi, R., Selenium nanoparticles:
synthesis, characterization andstudy of their cytotoxicity,antioxidant and antibacterial activity.
Mater. Res. Express 2019, 6 (8).

Concept
Keywords
Ethical ComplianceTechnical Compliance

47. Muthu, S.; Raju, V.; Gopal, V. B.;
Gunasekaran, A.; Narayan, K. S.;
Malairaj, S.; Lakshmikanthan, M.;
Duraisamy, N.; Krishnan, K.;Perumal, P., A rapid synthesis andantibacterial property of selenium
nanoparticles using egg whitelysozyme as a stabilizing agent. SNAppl. Sci. 2019, 1, 1543.

48. Kim, K. S.; Lee, D.; Song, C. G.;
Kang, P. M., Reactive oxygen speciesactivated nanomaterials as
theranostic agents. Nanomedicine(London, U. K.) 2015, 10 (17), 270923.

Figures

Expert’s comment - Figures

Figures help in presenting information in aclear, condensed manner. Every gure usedmust be cited in the main text. Journals may
restrict the number of gures to use orwhether they should be placed in themanuscript or submitted separately. Make
sure your manuscript adheres to your target
journal's instructions.

I have suggested a caption for gure 3.

 The use of gures has been detected inyour paper.

 A caption is missing for gure 3
 All gures are cited.
 All gures seem to be cited in order.

TablesExpert’s comment - Tables

Tables help in presenting a large amount ofdata in a comprehensible manner. Everytable must be cited in the main text. Journals
may restrict the number of tables that canbe used. Make sure your manuscript
adheres to your target journal's instructions.

I have suggested a caption for table 1.

 The use of tables has been detected inyour paper.

 A caption is missing for table 1
 All tables are cited.

 All tables seems to be cited in order.

Arti cialIntelligence Report

OverivewConcept
Keywords
Ethical ComplianceTechnical Compliance