Product Safety Summary for Pentanediol
SUBSTANCE NAME
Pentanediol
1,5-Pentandiol
1,5-Pentanediol
1,5-Pentanediol (8CI, 9CI)
Pentane-1,5-diol
1,5- Dihydroxypentane
Pentamethyleneglycol
1,5-Pentamethylene glycol
Pentyleneglycol
omega.-Pentanediol
alpha.,.omega.-Pentanediol

GENERAL STATEMENT
Pentanediol is a colorless, odorless liquid. It is neither hazardous for human health nor for the environment.
Pentanediol has a wide range of applications. It has two functional groups which are useful in the productionof various polymers and plastic products. But it also finds application in other chemical processes as well as it
is contained in different consumer products.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:pentane-1,5-diol
203-854-4
111-29-5
C5H12O2

USES AND APPLICATIONS
Pentanediol is obtained after treatment of the mixture of products resulting from the oxidation of
cyclohexane with air. Pentanediol is used to produce materials made of polyester or polyurethane, for themanufacturing of monomers, for the manufacture of polyester polyols, polycarbonatedioles and acrylicmonomers, for the production of delta valerolactone and for molecules that act as reactive diluents, for theproduction of halogenated substances and for the production of adhesives, putties and sealing compounds,cleaners and auxiliary agents. Pentanediol is also used in the processes to produce hydrogen, hydrogen
peroxide, sodium perborate and peroxyacetic acid and as an intermediate for pharmaceutical products. It isused as an ingredient for the production of polymeric thickeners, plasticizers for polyvinyl chloride, sizingagents, surfactants, for starches and chemically modified starch for application in the paper, textile and foodindustry, for personal hygiene products like shampoo, creams, and for paints.

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Product Safety Summary for Pentanediol
PHYSICAL CHEMICAL PROPERTIES
Pentanediol is a colorless and odorless liquid at room temperature.
Melting point/range:
Boiling point/boiling range:
Decomposition temperature:
Flashpoint:
Flammability (solid, gaseous):
Autoignition temperature:
Explosion limits:
Lower:
Upper:
Explosive properties:
Molecular weight:
log Pow:
Vapor pressure:
Relative density:
Solubility in/Miscibility
with water:
Oxidizing properties:

ca. -16 °C
238 °C at 1013.25 hPaNot determined
142 °C (closed cup)
Not flammable upon ignition
330 °C1.3 %13.2 %
Non explosive.
104.1476 g/mol-0.49 at 25 °C
0.0052 hPa at 25 °C
0.985 g/cm3 at 25.2 °C
Miscible in any ratio at 20 °C
No oxidizing properties

HEALTH EFFECTS
Pentanediol has no marked health hazard properties. Its acute toxicity is very low via all routes of exposure
tested (oral, skin and inhalation). It has no irritation or sensitization effects. Limited repeated dose and longterm health or reproductive effects has been generated with Pentanediol itself. More extensive data isavailable for the analogous substance Hexanediol. Based on the total amount of information available
Pentanediol is not expected to cause repeated dose or long term health effects. The physical properties ofPentanediol give no rise to concern. Its flammability is low. Therefore, Pentanediol has a very low overall
human health hazard potential.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Repeated Dose ExposureMutagenicity
Carcinogenicity
Reproductive Toxicity

April 10th, 2012RESULT
Pentanediol is of low acute toxicity via all routes of exposure.
Pentanediol is not irritating to the skin or to the eyes. Corrosivity
was not tested on the basis of the absence of irritation properties.
Based on the available data, Pentanediol is not considered to haveskin or respiratory sensitization properties.
Oral repeated dose test results with an analogous substance(Hexanediol) suggest that no marked toxicity should be expected.
Dermal and inhalation repeated dose exposure testing is
considered unnecessary based on expected exposure routes andthe oral repeated dose test result.
All available in vitro test data on Pentanediol and the analogous
Hexanediol indicates that bioaccumulation is not expected.
No carcinogenicity data has been generated due to the negative
mutagenicity results.
Screening test information with the analogous Hexanediol suggests
Pentanediol should have no adverse reprotoxicicity effects either.

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Product Safety Summary for Pentanediol
ENVIRONMENTAL EFFECTS
The results of all three acute aquatic studies on fish, algae, plants and invertebrates indicate a low
environmental acute hazard potential for Pentanediol. Pentanediol is readily biodegradable and it has a very
low bioaccumulation potential. Considering all available data on biotic and abiotic degradation,
bioaccumulation and toxicity, it can be stated that the substance is neither persistent nor toxic to theenvironment and that it will not bio-accumulate. Overall Pentanediol has a very low environmental hazard
potential.
EFFECT ASSESSMENT
Aquatic Toxicity

RESULTFish, daphnia, algae and plants studies indicate that the aquatic
toxicity of Pentanediol is low.

FATE AND BEHAVIOR
Biodegradation

RESULT
Pentanediol is readily biodegradable, based on test results with
Pentanediol itself and analogous substances (Hexanediol andButanediol).
Pentanediol will preferentially distribute to water. Based on thevalue of the partition coefficient it is concluded thatbioaccumulation is not expected.
Based on its low toxicity, bioaccumulation potential and readybiodegradability, Pentanediol does not meet the criteria for PBT orvPvB.

Bioaccumulation potential

PBT/vPvB conclusion

EXPOSURE
Human HealthPentanediol is used in many different applications. In industrial sites it is used for the production ofhydrogen, hydrogen peroxide, sodium perborate and peroxyacetic acid. But its main industrial use is as
monomer or reactant, therefore, Pentanediol will no longer be present as such in downstream products,
practically eliminating the exposure potential for professional users and consumers.
On the other hand, Pentanediol is contained in formulated products of common use, such as adhesives,putties, sealing compounds, cleaners, paints and inks, synthetic resins and personal hygiene products(shampoo, creams, etc.). In all previous cases, Pentanediol occurs in diluted form, so professionals andconsumers level of exposure will be very low.
Environment
Pentanediol is liquid at room temperature and it has relatively low volatility. The probability of release inpure form to any of the environmental compartments is low under normal industrial use conditions. Theremay be some release to waste water streams as a result of normal use or industrial cleaning operations, but,
as Pentanediol is readily biodegradable, this should not cause further environmental exposure.

RISK MANAGEMENT RECOMMENDATIONS
Pentanediol poses very low human health and environmental risks. However, it is a good practice to train
personnel handling the substance and to protect workers who may be exposed to Pentanediol by taking theusual precautionary measures to protect against chemical exposure. Therefore, protective clothing, gloves
and safety glasses with side shields should be worn when handling this substance. Good ventilation isrequired in areas where Pentanediol is handled. Respiratory protection is not required unless pentanediol isApril 10th, 2012Page 3

Product Safety Summary for Pentanediol
released in the form of gas or in the form of aerosols. Pentanediol is not flammable, however, it is a goodpractice to prevent the build-up of electrostatic charge when storing it.
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Pentanediol is included in the OECD list of High Production Volume (HPV) chemicals, but a SIDS is not yetavailable.
Pentanediol is listed in the following Chemical Inventories: AICS, NZIoC, KECI, PICCS, IECSC, EINECS, Canada
DSL, TSCA, ENCS.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.
Labeling according to REGULATION (EC) No 1272/2008:
Pictogram: none
Signal word: none
Hazard statements: none

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Department:
Address:
Town/Country:Postal code:
E-mail:UBE Chemical Europe, S.A
Corporate Social Responsibility
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

GLOSSARY
Acute toxicity
AICS
Biodegradation
Bioaccumulation

April 10th, 2012

Harmful effect resulting from a single or shortterm exposure to a substance.
Australian Inventory of Chemical Substances.
Decomposition or breakdown of a substance undernatural conditions (actions of micro-organismsetc).
Progressive accumulation in living organisms of aPage 4

Product Safety Summary for Pentanediol
Canadian DSL
Carcinogenicity
CAS
Chronic toxicity
EINECS
ENCS
Flash point
Genotoxicity
GHS
HPV
Hydrolyze
IECSC
Intermediate
KECI
Monomer

Mutagenicity
NZIoC
PBT
Persistence
PICCS
Risk Management Measures

REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment

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chemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
Existing Notified Chemical Substances (Japan).
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabeling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Inventory of Existing Chemical Substances
Produced or Imported in China.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Korean Existing Chemical Inventory.
Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
New Zealand Inventory of Chemicals
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Philippine Inventory of Chemicals and ChemicalSubstances.
Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning theRegistration, Evaluation, Authorization andRestriction of Chemicals.
European Commission Regulation onClassification, Labeling and Packaging of
Substances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofrivers and sea.

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Product Safety Summary for Pentanediol
TSCA
Vapor pressure
vPvB

Toxic Substance Control Act (USA).
A measure of a substance’s property to evaporate.
Very persistent, very bio-accumulative.

DATE OF ISSUE
April 2012

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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