YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
1/9

Safety Data Sheet
１． PRODUCT AND COMPANY IDENTIFICATION
Product Name:
Product number:
Manufacturer:First issue: May 13, 2009

Corticosterone EIA Kit
YK240
YANAIHARA INSTITUTE, INC.
Address: 2480-1, Awakura, Fujinomiya-shi
Shizuoka, Japan 418-0011
Tel:+81-544-22-2771(Japan)
Fax:+81-544-22-2770
E-mail:ask@yanaihara.co.jp
Seventh issue: December 16, 2019

２． HAZARDS IDENTIFICATIONGHS classification
Classification of the substance or mixture 6)
Acute toxicity - Inhalation (Dusts/Mists)
Skin corrosion/irritation
Serious eye damage/eye irritation
Specific target organ toxicity (single exposure)
Category 1 respiratory system
Specific target organ toxicity (repeated exposure)
Category 1 respiratory system

Category 4
Category 1ACategory 1
Category 1
Category 1

Pictograms

Signal wordDanger
Hazard statements
H314 - Causes severe skin burns and eye damage
H318 - Causes serious eye damage
H332 - Harmful if inhaled
H370 - Causes damage to the following organs: respiratory system
H372 - Causes damage to the following organs through prolonged or repeated exposure:respiratory system

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
2/9

Precautionary statements-(Prevention)
Do not breathe dust/fume/gas/mist/vapors/spray
Wash face, hands and any exposed skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Precautionary statements-(Response)
IF SWALLOWED: Rinse mouth. Do not induce vomiting.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin withwater/shower.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable forbreathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
Wash contaminated clothing before reuse.
Precautionary statements-(Storage)
Store locked up
Store in a well-ventilated place. Keep container tightly closed.
Precautionary statements-(Disposal)
Dispose of contents/container to an approved waste disposal plant
OthersOther hazards Not available
Other reagents may be harmful if inhaled and ingested. May cause eye and skin irritation.

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
3/9

３． COMPOSITION, INFORMATION ON INGREDIENTS
Product Name
Corticosterone EIA Kit

CAS NumberNone

Kit components:NoComponent

1)

Antibody Coated Plate

1 plate2)
3)

Corticosterone Standard
HRP-LabeledCorticosterone
Specific Antibody
TMB Substrate

50 ng
0.3 mL
7 mL
12 mL

Plate coated with goat anti rabbit IgG
antibody ①
Synthetic corticosterone ②Horse radish peroxidase- Corticosterone③Rabbit anti Corticosterone antibody ④3,3’,5,5’-Tetramethylbenzidine ⑤

Reaction Stopping
Solution
Buffer Solution

12 mL

Sulfuric acid (1M) ⑥10 mL

Sodium hydrogen phosphate ⑦
EDTA-2Na⑧
BSA⑨8)
9)

Sample Diluent
Concentrated Wash
Solution

50 mL
25 mL

A specific CBG displacer ⑩
Sodium chloride ⑪
Polyoxyethylene sorbitan monolaurate(Tween20) ⑫10)Adhesive Foil

2 sheets4)
5)
6)
7)

Quantity

Chemical name

Wt%NoInformation
9.69%

0.1-0.7%
18%
1%

CAS No.

Chemical Formula

50-22-6

C21H30O4

54827-17-7

C16H20N27664-93-9

H2SO4

7558-80-7
6381-92-6

NaH2PO4
C10H14N2Na2O8.2H2O

7647-14-5
9005-64-5

NaCl
C58H114O26

４．FIRST AID MEASURES
Inhalation:
Immediately remove victim to fresh air. Consult a physician if necessary.
Eye contact: Immediately flush eyes with flooding amounts of running water for at least 15minutes. Consult a physician if necessary.
Skin contact: Immediately remove contaminated clothes and shoes, flush skin with plenty ofwater or shower. Wash contaminated clothing and shoes.
Consult a physician if necessary.
Ingestion:
Immediately seek medical attention.
５． FIRE FIGHTING MEASURES
Flammable properties:
Nonflammable
Extinguishing media:
Foam, Carbon dioxide, dry chemical powder, soil, waterFire fighting instructions:
May emit toxic fumes under fire conditions. Wear full fire fighting
protective equipment including self-contained breathing apparatus.
Do not contact to the components when extinguish fire.
６．ACCIDENTAL RELEASE MEASURES
Personal precautions:Remove all ignition sources and ventilate. Wear suitable protective
equipment. Avoid contact with skin and eyes. Keep off except persons
concerned.
Environmental precautions: Prevent spills from entering sewers, watercourses or low area, and preventfrom affecting environment.

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
4/9

Methods for Clean up:

In case of spill of liquid material, take up or cover spilled material withashes or other incombustible absorbents, and put in a container to be sealed.
After completely picked up, dispose. In case of spill of solid or powdermaterial, prevent causing dust, sweep and collect, and put in a container tobe sealed. Wash the spill site with water.

７．HANDLING AND STORAGE
Handling:

Storage:

Obtain a package insert before use.
Read all the cautions for safety in the package insert before use.
Avoid strong light.
Avoid contact, inhalation and swallow.
Use only in open air or ventilated area.
Prevent from entering eyes.
Ventilate the area to keep concentration in air below exposure limits.
Avoid inhalation of mist, vapor and spray of material.
Avoid contact with eyes, skin and clothing.
Do not smoke and eat while using this kit.
Wash hands thoroughly after handling.
Prevent from entering environment.
Handle materials with suitable protection.
Use suitable equipments.
Do not pipette by mouth.
Do not leak, overflow and scatter.
Do not fall down and damage.
Store away from sunlight in a cool and dark place at 36-47ﾟF (2-8ﾟC).

８．EXPOSURE CONTOROLS, PERSONAL PROTECTION
Engineering measures: General ventilation and/or local exhaust ventilation as well as process isolation isnecessary to minimize employee exposure and maintain exposure limits below
exposure limits. Equip eye flushing facilities and shower rooms near operating
place where this kit is handled or stored.
Control parameter:⑥ OSHA Final Limits;
JSOH (Japan);
ACGIH TLV(s);TWA= 1 mg/m3
TWA= 1 mg/m3
TWA= 0.2 mg/m3

Personal protection:
Respiratory protection; NIOSH and MSHA approved respirator.
Hand protection;
Suitable impervious gloves.
Eye protection;
Suitable safety glasses (goggles).
Skin protection;
Suitable protective clothing.
Others:Wash hands thoroughly after handling materials.

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
5/9

９． PHYSICAL AND CHEMICAL PROPERTIES

AppearancepH
Melting point
Boiling point
Flash point
Explosivelimits
Vapor
pressure
Vapor density(air=1)
Specific
gravity
Solubility inwater
Decomposition
temperature

1)

2)

3)

4)

5)

6)

7)

8)

9)

ColorlessplateWhitecolor
lyophilized
powderColorlesstransparent
liquidColorlesstransparent
liquidColorlessto paleyellowliquidColorlesstransparentliquid

Colorlesstransparent
liquidColorlesstransparent
liquidColorlesstransparent
liquid10)

Colorlesstransparent
polymersheet

N/A
N/A
N/A
N/A

N/A

D/N/A

D/N/A

3.3-3.8

D/N/A

6.8

D/N/A

D/N/A

D/N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A
Not
explosive

N/A
N/A
N/A
N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

1.01

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

Insoluble

SolubleMixableMixableMixableMixableMixableMixableMixableInsoluble

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

N/A: Not applicable;
D/N/A: data not available

10． STABILITY AND REACTIVITY
Chemical stability:
Shelf life:
Hazardous polymerization:
Conditions to avoid:

Product is stable under normal handling.
Stable up to 24 months after manufacturing.
Will not occur.
Extremes of temperature and direct sunlight, heat, flames andsparks, static electricity, spark, moisture
Incompatibility with other materials: Alkaline substances, metals, strong oxidizing agents
Hazardous decomposition products:
Sulfur oxides(SOx), Carbon monoxide(CO), carbon dioxide(CO2),
Nitrogen oxides(NOx)11．TOXICOLOGICAL INFORMATION
Information as the mixture is not available.
Acute toxicity: 5) Not classified
6) Sulfuric acid (inhalation, rat); 2H LC50=510mg/m3(oral, rat) LD50=2140mg/kg
Category 4
Hazard statement; Harmful if inhaled.
Content=9.69%
9) Tween 20 (oral, rat); LD50=37000mg/kg
Sodium chloride (oral, rat); LD50=3000mg/kg
Not classified
Skin corrosion/irritation:5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification.
Category 1A

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
6/9

Hazard statement; Causes severe skin burns and eye damage.
Content=9.69%
9) Tween 20 (skin, human); 15mg/3days, Mild
Sodium chloride (skin, rabbit); 500mg/24H, Mild
Category 3
Hazard statement; Skin irritantSerious eye damage/irritation:5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1
Hazard statement; Causes serious eye damage.
Content=9.69%
9) Tween 20 (eye); R-phase(s) =R36 (Irritating to eyes)
Sodium chloride (eye, rabbit); 100mg/24H, Medium
Category 2B
Hazard statement; Causes eye irritation.
Respiratory or skin sensitization:
Respiratory sensitization
5) Not classified
6) Sulfuric acid; No data available.
Skin sensitization
5) Not classified
6) Sulfuric acid; No data available.
Germ cell mutagenicity:5) Not classified
6) Sulfuric acid; No data available.
Carcinogenicity:5) Not classified
6) Sulfuric acid; Occupational exposure to Mist of inorganic strong acids
including sulfuric acid is classified to group 1 in IARC (to havecarcinogenicity for human ), group A2 in ACGIH (suspectedhuman carcinogens) and group K in NTP (known to havecarcinogenicity for human). With respect for the evaluation by
IARC and current evaluation by NTP, it should be classified tocategory 1, however since sulfuric acid itself is classified toCategory 4 in DFGOT and is not classified to carcinogen by anyother organization,component 6) cannot be classified.
Reproductive toxicity:5) Not classified
6) Sulfuric acid; No data available.

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
7/9

Specific target organ systemic toxicity/Single exposure:5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system
Hazard statement; Causes damage to the following organs: respiratorysystem.
Content=9.69%
Specific target organ systemic toxicity/Repeated exposure:5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system
Hazard statement; Causes damage to respiratory system with long term or
repeated exposure: respiratory system.
Content=9.69%
12． ECOLOGICAL INFORMATION
Information as the mixture is not available.
Aquatic environmental toxicity/Acute phase:5) No information available.
6) Sulfuric acid; In fish (Bluegill), 96H LC50=16-28mg/L
Daphnia magna 24H EC50=29mg/L
Hazard statement; Harmful to aquatic life.
Aquatic environmental toxicity/Chronical phase:6) Sulfuric acid; Based on the NITE GHS classification results.
13．DISPOSAL CONSIDERATIONS
Dispose of all waste material including containers in accordance with all applicable laws and local
environmental regulations.
14．TRANSPORT INFORMATION
IATA: As a mixture, the substance is subjected to no limitations.
15． REGULATORY INFORMATIONInternational Inventories
EINECS/ELINCS
ListedTSCA
ListedJapanese regulations
Fire Service Act; Not applicable
Poisonous and Deleterious Substances Control Law; Not applicable
Industrial Safety and Health Act;
Group 3 Specified Chemical Substance, (Ordinance on Prevention ofYK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
8/9

Hazards Due to Specified Chemical Substances Art.2 Para.1, Item 6)
Harmful Substances Whose Names Are to be Indicated on the Label(Law Art.57, Para.1, Enforcement Order Art.18)
Notifiable Substances (Law Art.57-2, Enforcement Oder Art.18-2No.613
Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc.;
Priority Assessment Chemical Substances (Law Article 2, Para.5)
Regulations for the carriage and storage of dangerous goods in ship;
Corrosive Substances(Ordinance Art.3, Ministry of Transportation
Ordinance Regarding Transport by Ship and Storage)
Civil Aeronautics Law;
Corrosive Substances (Ordinance Art.194, MITL Nortification for Air
Transportation of Explosives etc.)
Air pollution Control Law; Specified substance
EU Directive 1999/45/EC; classification, packaging and labeling of dangerous Preparations
SYMBOL : C as component 6)
R-phrases : 35 as component 6)
S-phrases : 26-45 as component 6)
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of accident or if you feel unwell, seek medical advice immediately.
EC index No. : ⑤=259-364-6, ⑥=016-020-00-8
Other ingredients=Not listed.
Follow all the regulations in your country.
16． OTHER INFORMATION
Reference
1) Internal data of Yanaihara Institute, Inc.
2) Chemwatch MSDS
3) RTECS (2006)
4) EU RAR (2003)
5) SIDS (2001)
6) Environmental Risk Assessment of Chemicals Vol.3 (Ministry of environment, Japan) (2004)
7) ATSDR (1998)
8) SIDS (2001)
9) DFDS (2001)
10) EU- RAR (2002)
11) SIDS (2003)
12) CERI・NITE Hazard Assessment Report (2005)
13) NTP DB (Access on Dec., 2005)
14) Narotsky and Kavlock (1995)

YK240 Corticosterone EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00240-008
June, 10, 2022
9/915) EHC 161 (1994)16) MSDS by Wako Pure Chemical Industries, Ltd.
17) ECETOC JACC (1993)
18) ACGIH (2001)19) NITE Biodegradation and Bioconcentration of the Existing Chemical Substances
20) PHYSPROP Database (2005)21) IUCLID (2000)
22) HSDB (2006)23) JSOH Recommendation of Occupational Exposure Limits (1993)24) IARC (1992)
25) ACGIH (2004)
Key literature references and sources for data etc. ;NITE: National Institute of Technology and Evaluation (JAPAN) http://www.safe.nite.go.jp/japan/db.html
IATA dangerous Goods Regulations RTECS: Registry of Toxic Effects of Chemical Substances Japan
Industrial Safety and Health Association GHS Model SDS Dictionary of Synthetic Organic Chemistry,
SSOCJ, Koudansha Scientific Co.Ltd. Chemical Dictionary, Kyouritsu Publishing Co., Ltd. etc.
The above information is believed to be correct to be the best of our knowledge and information,
but does not purport to be all inclusive and should be used as only a guide. This product is intended to
be used by expert persons having chemical knowledge and skill, at their own discretion and risk.
Yanaihara institute shall not be held liable for any damages resulting from handling or contact with theabove product. Users should determine the suitability of the information for their particular purpose.