Takanori TAKEBE

Promise and Impact of Organoid Medicine

Institute of Research, Tokyo Medical and Dental University, Japan
Communication Design Center, Yokohama City University, Japan
Division of Gastroenterology, Hepatology and Nutrition and Division ofDevelopmental Biology, Cincinnati Children's Hospital Medical Center, USA

Takanori TAKEBE
Institute of Research, Tokyo Medical and Dental University, Japan
Communication Design Center, Yokohama City University, Japan
Division of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology,

Contact : ttakebe.ior [at sign] tmd.ac.jp

Cincinnati Children's Hospital Medical Center, USA

Please replace [at sign] with @.

Research Interests
Stem cell and developmental biology, organoid medicine

organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The
current challenge is to engineer cellular complexity into organoids in a controlled manner that results in organizedassembly and acquisition of tissue function. These efforts have relied on studies of organ assembly during embryonicdevelopment and have resulted in development of organoids with multilayer tissue complexity and higher order

Education
2011
2019

Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions offunctions. For example, we show that antero-posterior interactions recapitulate the foregut and the midgut boundary
M.D., Yokohama City University School of Medicine
Ph.D., Yokohama City University School of Medicine

in vitro, modeling the inter-coordinated specification and invagination of the human hepato-biliary-pancreatic systemfrom human pluripotent stem cells. Coupled with patient-derived stem cells, my group studied the mechanisms ofhuman hepatic diseases that includes viral hepatitis, steatohepatitis, recently extended to drug induced liver injury(DILI), wherein organoid modelled the clinical phenotype and genotype are correlated. Here I will summarize the next

Professional Career
2011 - 20132013 - 2018

Research Associate, Department of Regenerative Medicine, Yokohama City University

2015 - present

Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition and Division of2017 - present

Director of Commercial Innovation, Center for Stem Cell and Organoid Medicine (CuSTOM),

2018 - present

Professor & Founding Director, Communication Design Center, Yokohama City University

2018 - present

Professor, Institute of Research, Tokyo Medical Dental University

and understand drug reactions underlying individual variations in humans.

Associate Professor, Department of Regenerative Medicine, Yokohama City University
Developmental Biology, Cincinnati Children's Hospital Medical Center, USA

References

Cincinnati Children’s Hospital Medical Center, USA

Scientific Activities
2018 - present

Deputy to the Chairman, Japanese Society for Regenerative Medicine (JSRM)

2018 - present

Board of Directors, International Society for Stem Cell Research (ISSCR)

Honors
2020
2018
2016

generation of organoid by design, and discuss its promise and impact to elucidate personalized disease mechanisms

NIH Director’s New Innovator Award, Bethesda, USA
JSPS Prize of The Japan Society for the Promotion of Science, Tokyo
Robertson Investigator Award, New-York Stem Cell Foundation, NY[ 1 ] Koike H, Iwasawa K, Ouchi R , Maezawa M, Giesbrecht K, Saiki N, R-R, Ferguson A, Kimura M , Wendy T, Wells J,Zorn A, and Takebe T: Modeling human hepato-biliary-pancreatic organogenesis from the foregut-midgut
boundary. Nature, 574(7776):112-116.
[ 2 ] Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns R, Mayhew C, McGrath PS,
McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C,
Yoshikawa HY, Wells JM, Takebe T*: Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived
Organoids. Cell Metabolism, 30(2):374-384, 2019 (*Correspondence)[ 3 ] Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal G, Daly, A, Watkins P, Anayama
H, Dragan Y, Shinozawa T and Takebe T*. Polygenic architecture informs potential vulnerability to drug-induced
liver injury. Nature Medicine, 2020. (* Correspondence), PMID: 32895570[ 4 ] Shinozawa T , Kimura M , Yuqi C, Saiki N, Yoneyama Y, Ouchi R , Koike H , Koido M, Zhang R-R, Dunn A, Ferguson
A, Togo S, Lewis K, Thompson W, Asai A , Takebe T*: High-Fidelity Drug Induced Liver Injury Screen Using Human
iPSC Liver Organoids. Gastroenterology, in press.

Publications
Koike H, Iwasawa K, Ouchi R , Maezawa M, Giesbrecht K, Saiki N, R-R, Ferguson A, Kimura M , Wendy T, Wells J, Zorn A, and Takebe T: Modeling

1. human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature, 574(7776):112-116, 2019.
2. Takebe T*, Wells JM *: Organoids-By-Design. Science, 364 (6444), 956-95, 2019. (* Correspondence)3.
12Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R,Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T*, Treutlein B*: Multilineage communication regulates human liver bud self-organization from pluripotency. Nature, 546, 533–534, 2017. (* Correspondence)

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