YK080 Human PYY EIA Kit/New type
YANAIHARA INSTITUTE, INC.
SDS No.00080-009
June 9, 2022
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Safety Data Sheet
１． PRODUCT AND COMPANY IDENTIFICATION
Product Name:
Product number:
Manufacturer:First issue:

July 8, 2010

Human PYY EIA Kit/New type
YK080
YANAIHARA INSTITUTE, INC.
Address: 2480-1, Awakura, Fujinomiya-shi
Shizuoka, Japan 418-0011
Tel:+81-544-22-2771(Japan)
Fax:+81-544-22-2770
E-mail:ask@yanaihara.co.jp
Ninth issue: June 9, 2022

２． HAZARDS IDENTIFICATIONGHS classification
Classification of the substance or mixture 4), 6)
Acute toxicity - Inhalation (Dusts/Mists)
Category 4
Skin corrosion/irritation
Category 1A, 2Serious eye damage/eye irritation
Category 1, 2ASpecific target organ toxicity (single exposure)
Category 1
Category 1 respiratory system, cardiovascular system, kidneys, nervous system
Specific target organ toxicity (repeated exposure)
Category 1
Category 1 respiratory system, cardiovascular system, liver, digestive system, blood system,
kidneys, pancreas, thymus, central nervous system
Germ cell mutagenicity
Category 1B
Reproductive Toxicity
Category 1B
Pictograms

Signal word
DangerHazard statements
H314 - Causes severe skin burns and eye damage
H315 - Causes skin irritation
H318 - Causes serious eye damage
H319 - Causes serious eye irritation
H332 - Harmful if inhaled
H340 - May cause genetic defects
H360 - May damage fertility or the unborn child
H370 - Causes damage to the following organs: respiratory system
H372 - Causes damage to the following organs through prolonged or repeated exposure:YK080 Human PYY EIA Kit/New type
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respiratory system
Precautionary statements-(Prevention)
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fumes/gas/mist/vapors/spray.
Wash face, hands and any exposed skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.

Precautionary statements-(Response)
Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/
shower.
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If exposed: Call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.
Wash contaminated clothing before reuse.
Precautionary statements-(Storage)
Store locked up
Store in a well-ventilated place. Keep container tightly closed.
Precautionary statements-(Disposal)
Dispose of contents/container to an approved waste disposal plant
OthersOther hazards Not available
Other reagents may be harmful if inhaled and ingested. May cause eye and skin irritation.

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SDS No.00080-009
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３． COMPOSITION, INFORMATION ON INGREDIENTS
Product Name
Human PYY EIA Kit/New type

CAS Number
None

Kit components:
No.
1)

Component
Antibody coated plate

Quantity
1 plate2)Standard

20 ng

3)

Labeled antigen

1 vial4)

SA-HRP solution

12 mL

5)

Enzyme substrate solution

12 mL

6)
7)
8)

Stopping solution
Buffer solution
Washing solution(concentrated)

12 mL
25 mL
50 mL

9)

Adhesive foil

3 sheets

Chemical namePlate coated with rabbit anti human PYY
antibody ①
Synthetic human PYY(3-36) (Lyophilized)②
Biotinylated human PYY(3-36)(Lyophilized) ③
HRP labeled Streptavidin④
Phenol⑤chloramphenicol⑥
3,3’,5,5’-Tetramethylbenzidine⑦
Sulfuric acid (1M)⑧
Tris/saline buffer⑨
Sodium chloride ⑩
Polyoxyethylene sorbitan monolaurate(Tween20) ⑪Wt%

CAS No.

Chemical Formula

0.096%
0.02%
No
information
9.69%

108-95-2
56-75-7
54827-17-7

C6H5OHC11H12CL2N2O5
C16H20N2

7664-93-9

H2SO4

18%

7647-14-5

NaCl

1%

9005-64-5

C58H114O26

４． FIRST AID MEASURES
Inhalation:
Immediately remove victim to fresh air. Consult a physician if necessary.
Eye contact: Immediately flush eyes with flooding amounts of running water for at least 15
minutes. Consult a physician if necessary.
Skin contact: Immediately remove contaminated clothes and shoes, flush skin with plenty ofwater or shower. Wash contaminated clothing and shoes.
Consult a physician if necessary.
Ingestion:
Immediately seek medical attention.
５． FIRE FIGHTING MEASURES
Flammable properties:
Nonflammable
Extinguishing media:
Foam, Carbon dioxide, dry chemical powder, soil, waterFire fighting instructions:
May emit toxic fumes under fire conditions. Wear full fire fighting
protective equipment including self-contained breathing apparatus.
Do not contact to the components when extinguish fire.
６． ACCIDENTAL RELEASE MEASURES
Personal precautions:Remove all ignition sources and ventilate. Wear suitable protective
equipment. Avoid contact with skin and eyes. Keep off except persons
concerned.
Environmental precautions: Prevent spills from entering sewers, watercourses or low area, and preventfrom affecting environment.
Methods for Clean up:
In case of spill of liquid material, take up or cover spilled material withashes or other incombustible absorbents, and put in a container to be sealed.
After completely picked up, dispose. In case of spill of solid or powdermaterial, prevent causing dust, sweep and collect, and put in a container toYK080 Human PYY EIA Kit/New type
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be sealed. Wash the spill site with water.
７． HANDLING AND STORAGE
Handling:

Storage:

Obtain a package insert before use.
Read all the cautions for safety in the package insert before use.
Avoid strong light.
Avoid contact, inhalation and swallow.
Use only in open air or ventilated area.
Prevent from entering eyes.
Ventilate the area to keep concentration in air below exposure limits.
Avoid inhalation of mist, vapor and spray of material.
Avoid contact with eyes, skin and clothing.
Do not smoke and eat while using this kit.
Wash hands thoroughly after handling.
Prevent from entering environment.
Handle materials with suitable protection.
Use suitable equipments.
Do not pipette by mouth.
Do not leak, overflow and scatter.
Do not fall down and damage.
Store away from sunlight in a cool and dark place at 36-47ﾟF (2-8ﾟC).

８． EXPOSURE CONTOROLS, PERSONAL PROTECTION
Engineering measures: General ventilation and/or local exhaust ventilation as well as process isolationis necessary to minimize employee exposure and maintain exposure limits below
exposure limits. Equip eye flushing facilities and shower rooms near operating
place where this kit is handled or stored.

Control parameter:⑤ OSHA Final Limits;
JSOH (Japan);
ACGIH TLV(s);⑧ OSHA Final Limits;
JSOH (Japan);
ACGIH TLV(s);TWA= 5 ppm
TWA= 5 ppm OEL
TWA= 19mg/m3 OEL Skin
TWA= 5 ppm Skin
TWA= 1 mg/m3
TWA= 1 mg/m3
TWA= 0.2 mg/m3

Personal protection:
Respiratory protection; NIOSH and MSHA approved respirator.
Hand protection;
Suitable impervious gloves.
Eye protection;
Suitable safety glasses (goggles).
Skin protection;
Suitable protective clothing.
Others:Wash hands thoroughly after handling materials.

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９． PHYSICAL AND CHEMICAL PROPERTIES
Component
Appearance

1)

2)

3)

4)

5)

6)

7)

Colorless plate

White color,lyophilized
powderWhite color,lyophilized
powderOrange color,
LiquidColorless topale yellow
liquidColorlesstransparent,
LiquidColorlesstransparent,
LiquidColorlesstransparent,
Liquid

N/A
D/N/A
N/A
D/N/A

N/A
D/N/A
N/A
D/N/A

6.8
N/A
D/N/A
D/N/A

3.3-3.8
N/A
D/N/A
D/N/A

<1.0
N/A
D/N/A
D/N/A

8.0
N/A
D/N/A
D/N/A

D/N/A
N/A
D/N/A
D/N/A

9)
Colorlesstransparent
Polymer
sheet
N/A
N/A
N/A
N/A

D/N/A

D/N/A

D/N/A

Not explosive

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

1.01

D/N/A

D/N/A

D/N/A

D/N/A

SolubleSolubleMixableMixableMixableMixableMixableInsoluble

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

pH
N/A
Melting point
N/A
Boiling point
N/A
Flash point
N/A
Explosive
N/A
limitsVapor
N/A
pressure
Vapor density
N/A(air=1)
Specifics
D/N/A
gravity
Solubility in
Insoluble
water
Decomposition
N/A
temperature
N/A: Not applicable
D/N/A: data not available

10． STABILITY AND REACTIVITY
Chemical stability:
Shelf life:
Hazardous polymerization:
Conditions to avoid:

8)

Product is stable under normal handling.
Stable up to 24 months after manufacturing.
Will not occur.
Extremes of temperature and direct sunlight, heat, flames andsparks, static electricity, spark, moisture
Incompatibility with other materials: Alkaline substances, metals, strong oxidizing agents
Hazardous decomposition products:
Sulfur oxides(SOx), Carbon monoxide(CO), carbon dioxide(CO2),
Nitrogen oxides(NOx)

11． TOXICOLOGICAL INFORMATION
Information as the mixture is not available.
Acute toxicity: 4) Phenol (oral, rat); LD50=375mg/kg(dermal rabbit) LD50=670mg/kg
Chloramphenicol (oral, rat); LD50=2500mg/kg
ATE=319.8
Hazard statement; Harmful if swallowed.
5) Not classified
6) Sulfuric acid (inhalation, rat); 2H LC50=510mg/m3(oral, rat) LD50=2140mg/kg
Category 4
Hazard statement; Harmful if inhaled.
Content=9.69%
8) Tween 20 (oral, rat); LD50=37000mg/kg
Sodium chloride (oral, rat); LD50=3000mg/kg
Not classified

YK080 Human PYY EIA Kit/New type
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SDS No.00080-009
June 9, 2022
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Skin corrosion/irritation:4) Phenol; Based on the NITE GHS classification results.
Category 2
Hazard statement; Causes skin irritation.
Content=0.096%
Chloramphenicol; Information not available.
Not classified
5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification.
Category 1AHazard statement; Causes severe skin burns and eye damage.
Content=9.69%
8) Tween 20 (skin, human); 15mg/3days, Mild
Sodium chloride (skin, rabbit); 500mg/24H, Mild
Category 3
Hazard statement; Skin irritantSerious eye damage/irritation:4) Phenol; Based on the NITE GHS classification results.
Category 2AHazard statement; Causes serious eye irritation.
Content=0.096%
Chloramphenicol; Information not available.
Not categorized5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1
Hazard statement; Causes serious eye damage.
Content=9.69%
8) Tween 20 (eye); R-phase(s) =R36 (Irritating to eyes)
Sodium chloride (eye, rabbit); 100mg/24H, Medium
Category 2B
Hazard statement; Causes eye irritation.
Respiratory or skin sensitization:
Respiratory sensitization
4) Phenol; Based on the NITE GHS classification results.
Chloramphenicol; Information not available.
5) Not classified
6) Sulfuric acid; No data available.
Skin sensitization
4) Phenol; Based on the NITE GHS classification results.
Chloramphenicol (skin); Causes allergic skin reaction. Content=0.02%
Not classified
5) Not classified
6) Sulfuric acid; No data available.

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Germ cell mutagenicity:4) Phenol; Based on the NITE GHS classification results.
Category 1B
Hazard statement; May cause genetic defects.
Content=0.096%
Chloramphenicol; Information not available.
5) Not classified
6) Sulfuric acid; No data available.
Carcinogenicity:4) Phenol; IARC group 3 (substances which can not be classified to humancarcinogens), ACGIH: A4 (2005), IRIS: D (2002)
Chloramphenicol; IARC group 2A (substances which may be carcinogenic tohuman), Content=0.02%
Not classified
5) Not classified
6) Sulfuric acid; Occupational exposure to mist of inorganic strong acids including
sulfuric acid is classified to group 1 in IARC (to havecarcinogenicity for human), group A2 in ACGIH (suspected humancarcinogens) and group K in NTP (known to have carcinogenicity
for human). With respect for the evaluation by IARC and current
evaluation by NTP, it should be classified to category 1, however
since sulfuric acid itself is classified to Category 4 in DFGOT and is
not classified to carcinogen by any other organization, component6) can not be classified.

Reproductive toxicity:4) Phenol; Based on the NITE GHS classification results.
Category 1B
Hazard statement; May damage fertility or the unborn child.
Content=0.096%
Chloramphenicol; Information not available.
5) Not classified
6) Sulfuric acid; No data available.
Specific target organ systemic toxicity/Single exposure:4) Phenol; Based on the NITE GHS classification results.
Category 1 respiratory system, cardiovascular system, kidney andnervous system
Hazard statement; Causes damage to following organs: respiratory
system, cardiovascular system, kidneys, nervous
system.
Content=0.096%
Chloramphenicol; Information not available.
5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system

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SDS No.00080-009
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Hazard statement; Causes damage to the following organs: respiratory system.
Content=9.69%
Specific target organ systemic toxicity/Repeated exposure:4) Phenol; Based on the NITE GHS classification results.
Category 1 cardiovascular system, liver, digestive system, blood
system, kidney, pancreas, thymus, central nervous system
Hazard statement; Causes damage to the following organs throughprolonged or repeated exposure: cardiovascular system,
liver, digestive system, blood system, kidneys,
pancreas, thymus, central nervous system.
Content=0.096%
Chloramphenicol; Information not available.
5) Not classified
6) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system
Hazard statement; Causes damage to respiratory system with long term or
repeated exposure: respiratory system.
Content=9.69%
12． ECOLOGICAL INFORMATION
Information as the mixture is not available.
Aquatic environmental toxicity/Acute phase:4) Phenol; Ceriodaphnia: EC50=3.1mg/L/48h (EU-RAR, 2002)
Algae/aquatic plants (Pseudokirchneriella subcapitata)
96H EC50=46.42 mg/L
Fish (Pimephales promelas) 96H LC50=11.9-50.5mg/L
Crustacea (Daphnia magna), 48H EC50=4.24-10.7 mg/L
Chloramphenicol; 96H LC50=15-42μg/L
Component 4) is not classified.
5) No information available.
6) Sulfuric acid; In fish (Bluegill), 96H LC50=16-28mg/L
Daphnia magna 24H EC50=29mg/L
Hazard statement; Harmful to aquatic life.
Aquatic environmental toxicity/Chronical phase:4) Phenol; Based on the NITE GHS classification results.
Chloramphenicol; Has rapid degradability.
Component 4) is not classified.
6) Sulfuric acid; Based on the NITE GHS classification results.
13． DISPOSAL CONSIDERATIONS
Dispose of all waste material including containers in accordance with all applicable laws and local
environmental regulations.

YK080 Human PYY EIA Kit/New type
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SDS No.00080-009
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14． TRANSPORT INFORMATION
IATA: As a mixture, the substance is subjected to no limitations.
15． REGULATORY INFORMATIONInternational Inventories
EINECS/ELINCS
ListedTSCA
ListedJapanese regulations
Fire Service Act; Not applicable
Poisonous and Deleterious Substances Control Law; Not applicable
Industrial Safety and Health Act;
Group 3 Specified Chemical Substance, (Ordinance on Prevention ofHazards Due to Specified Chemical Substances Art.2 Para.1, Item 6)
Harmful Substances Whose Names Are to be Indicated on the Label(Law Art.57, Para.1, Enforcement Order Art.18)
Notifiable Substances (Law Art.57-2, Enforcement Oder Art.18-2
No.613, 474
Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc.;
Priority Assessment Chemical Substances (Law Article 2, Para.5)
Regulations for the carriage and storage of dangerous goods in ship;
Corrosive Substances(Ordinance Art.3, Ministry of Transportation
Ordinance Regarding Transport by Ship and Storage)
Civil Aeronautics Law;
Corrosive Substances (Ordinance Art.194, MITL Nortification for Air
Transportation of Explosives etc.)
Marine Pollution Prevention Law Pollutant Release and Transfer Register Law;Class 1
Class 1 - No. 349
Air pollution Control Law; Specified substance
EU Directive 1999/45/EC; classification, packaging and labeling of dangerous Preparations
SYMBOL : C as component 6)
R-phrases : 35 as component 6)
S-phrases : 26-45 as component 6)
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of accident or if you feel unwell, seek medical advice immediately.
EC index No. : ⑤=604-001-00-2, ⑦=259-364-6 ⑧=016-020-00-8
Other ingredients=Not listed.
Follow all the regulations in your country.

YK080 Human PYY EIA Kit/New type
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SDS No.00080-009
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16． OTHER INFORMATION
Reference
1) Internal data of Yanaihara Institute, Inc.
2) Chemwathch MSDS
3) RTECS (2006)
4) EU RAR (2003)
5) SIDS (2001)
6) Environmental Risk Assessment of Chemicals Vol.3 (Ministry of environment, Japan) (2004)
7) ATSDR (1998)
8) SIDS (2001)
9) DFDS (2001)
10) EU- RAR (2002)
11) SIDS (2003)
12) CERI・NITE Hazard Assessment Report (2005)
13) NTP DB (Access on Dec., 2005)
14) Narotsky and Kavlock (1995)
15) EHC 161 (1994)16) MSDS by Wako Pure Chemical Industries, Ltd.
17) ECETOC JACC (1993)
18) ACGIH (2001)19) NITE Biodegradation and Bioconcentration of the Existing Chemical Substances
20) PHYSPROP Database (2005)21) IUCLID (2000)
22) HSDB (2006)23) JSOH Recommendation of Occupational Exposure Limits (1993)24) IARC (1992)
25) ACGIH (2004)
Key literature references and sources for data etc.;
NITE: National Institute of Technology and Evaluation (JAPAN) http://www.safe.nite.go.jp/japan/db.html
IATA dangerous Goods Regulations RTECS: Registry of Toxic Effects of Chemical Substances Japan
Industrial Safety and Health Association GHS Model SDS Dictionary of Synthetic Organic Chemistry,
SSOCJ, Koudansha Scientific Co.Ltd. Chemical Dictionary, Kyouritsu Publishing Co., Ltd. etc.
The above information is believed to be correct to be the best of our knowledge and information,
But does not purport to be all inclusive and should be used as only a guide. This product is intended
to be used by expert persons having chemical knowledge and skill, at their own discretion and risk.
Yanaihara institute shall not be held liable for any damages resulting from handling or contact withthe above product. Users should determine the suitability of the information for their particularpurpose.