YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
1/8

Safety Data Sheet
１． PRODUCT AND COMPANY IDENTIFICATION
Product Name:
Product number:
Manufacturer:First issue: Aug. 22, 2016

DHEA (saliva) EIA Kit
YK290
YANAIHARA INSTITUTE, INC.
Address: 2480-1, Awakura, Fujinomiya-shi
Shizuoka, Japan 418-0011
Tel:+81-544-22-2771(Japan)
Fax:+81-544-22-2770
E-mail:ask@yanaihara.co.jp
Seventh issue: June 10, 2022

２． HAZARDS IDENTIFICATIONGHS classification
Classification of the substance or mixture 7)
Acute toxicity - Inhalation (Dusts/Mists)
Skin corrosion/irritation
Serious eye damage/eye irritation
Specific target organ toxicity (single exposure)
Category 1 respiratory system
Specific target organ toxicity (repeated exposure)
Category 1 respiratory system

Category 4
Category 1ACategory 1
Category 1
Category 1

Pictograms

Signal word
DangerHazard statements
H314 - Causes severe skin burns and eye damage
H318 - Causes serious eye damage
H332 - Harmful if inhaled
H370 - Causes damage to the following organs: respiratory system
H372 - Causes damage to the following organs through prolonged or repeated exposure: respiratory
systemPrecautionary statements-(Prevention)
Do not breathe dust/fume/gas/mist/vapors/spray.
Wash face, hands and any exposed skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
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Wear protective gloves/protective clothing/eye protection/face protection.
Precautionary statements-(Response)
IF SWALLOWED: Rinse mouth. Do not induce vomiting.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin withwater/shower.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
Wash contaminated clothing before reuse.
Precautionary statements-(Storage)
Store locked up
Store in a well-ventilated place. Keep container tightly closed.
Precautionary statements-(Disposal)
Dispose of contents/container to an approved waste disposal plant
OthersOther hazards

Not available

Other reagents may be harmful if inhaled and ingested. May cause eye and skin irritation.
３． COMPOSITION, INFORMATION ON INGREDIENTS
Product Name
DHEA (saliva) EIA Kit

CAS Number
None

Kit components:
No.

Component

Quantity

Chemical nameWt%

CAS No.

Chemical Formula1)

Antibody Coated Plate

1 plateAnti-DHEA antibodies ①

2)

DHEA Standard

36.45ng

Dehydroepiandrosterone ②<1ppm

53-43-0

C19H28O2

3)

HRP-Labeled DHEA

0.6 mL

Horse radish peroxidase- DHEA ③

<1ppm

4)

Buffer Solution

30 mL

Trisodium citrate ④<0.1%

6132-04-3

C6H5Na3O7

Milk powder⑤

<0.1%

5)

TMB Substrate

12 mL

3,3’,5,5’-Tetramethylbenzidine ⑥

No Information

54827-17-7

C16H20N2

6)

Concentrated Wash Solution

50 mL

Sodium chloride ⑦

18%7647-14-5

NaCl

Polyoxyethylene sorbitan monolaurate (Tween20)⑧

1%9005-64-5

C58H114O26

Sulfuric acid (1M) ⑨

9.69%

7664-93-9

H2SO4

7)

Reaction Stopping Solution

12 mL

8)

Adhesive Foil

2 sheets

４． FIRST AID MEASURES
Inhalation:
Immediately remove victim to fresh air. Consult a physician if necessary.
Eye contact: Immediately flush eyes with flooding amounts of running water for at least 15

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
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Skin contact:

Ingestion:

minutes. Consult a physician if necessary.
Immediately remove contaminated clothes and shoes, flush skin with plenty ofwater or shower. Wash contaminated clothing and shoes.
Consult a physician if necessary.
Immediately seek medical attention.

５． FIRE FIGHTING MEASURES
Flammable properties:
Nonflammable
Extinguishing media:
No restriction; use any means suitable for extinguishing surrounding fire.
Firefighting instructions:
May emit toxic fumes under fire conditions. Wear full fire fighting
protective equipment including self-contained breathing apparatus.
Do not contact to the components when extinguish fire.
６． ACCIDENTAL RELEASE MEASURES
Personal precautions:Remove all ignition sources and ventilate. Wear suitable protective equipment.
Avoid contact with skin and eyes. Keep off except persons concerned.
Environmental precautions: Prevent spills from entering sewers, watercourses or low area, and prevent from
affecting environment.
Methods for Clean up:
In case of spill of liquid material, take up or cover spilled material with ashes orother incombustible absorbents, and put in a container to be sealed. Aftercompletely picked up, dispose. In case of spill of solid or powder material,
prevent causing dust, sweep and collect, and put in a container to be sealed.
Wash the spill site with water.
７． HANDLING AND STORAGE
Handling:
Obtain a package insert before use.
Read all the cautions for safety in the package insert before use.
Avoid strong light.
Avoid contact, inhalation and swallow.
Use only in open air or ventilated area.
Prevent from entering eyes.
Ventilate the area to keep concentration in air below exposure limits.
Avoid inhalation of mist, vapor and spray of material.
Avoid contact with eyes, skin and clothing.
Do not smoke and eat while using this kit.
Wash hands thoroughly after handling.
Prevent from entering environment.
Handle materials with suitable protection.
Use suitable equipment.
Do not pipette by mouth.
Do not leak, overflow and scatter.
Do not fall down and damage.
Storage:
Store away from sunlight in a cool and dark place at 36-47ﾟF (2-8ﾟC).

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
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８．EXPOSURE CONTOROLS, PERSONAL PROTECTION
Engineering measures:

General ventilation and/or local exhaust ventilation as well as process isolation isnecessary to minimize employee exposure and maintain exposure limits below
exposure limits. Equip eye flushing facilities and shower rooms near operating place
where this kit is handled or stored.

Control parameter:⑨ OSHA Final Limits;
JSOH (Japan);
ACGIH TLV(s);TWA= 1 mg/m3
TWA= 1 mg/m3
TWA= 0.2 mg/m3

Personal protection:
Respiratory protection; NIOSH and MSHA approved respirator.
Hand protection;
Suitable impervious gloves.
Eye protection;
Suitable safety glasses (goggles).
Skin protection; Suitable protective clothing.
Others:Wash hands thoroughly after handling materials.

９． PHYSICAL AND CHEMICAL PROPERTIES
Component

pH
Melting point
Boiling point
Flash point
Explosive limits
Vapor pressure
Vapor density(air=1)
Specific gravity

N/A
N/A
N/A
N/A
N/A
N/A

N/A

3)
Yellowish
transparent
liquid7.4

3.3-3.8

6)
Colorlesstransparent
liquid
7.4

D/N/A

N/A

N/A

N/A

N/A

N/A

N/A
D/N/A

D/N/A
D/N/A

D/N/A
D/N/A

D/N/A
D/N/A

D/N/A
D/N/A

D/N/A
D/N/A

D/N/A

D/N/A

D/N/A

Not explosive

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

8)
Colorlesstransparent
polymersheet
N/A
N/A
N/A
N/A
N/A
N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

1.01

D/N/A

D/N/A

D/N/A

Solubility in water

Insoluble

SolubleMixableMixableMixableMixableMixableInsoluble

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Appearance

1)
Colorlessplate

Decomposition
N/A
temperature
N/A.: Not applicable;
D/N/A: data not available

2)
White color
lyophilized
powder

10． STABILITY AND REACTIVITY
Chemical stability:
Shelf life:
Hazardous polymerization:
Conditions to avoid:

4)
Colorlesstransparent
liquid6.8

Colorless to paleyellow liquid

5)7)Colorlesstransparent
liquid<1.0

Product is stable under normal handling.
Stable up to 24 months after manufacturing.
Will not occur.
Extremes of temperature and direct sunlight, heat, flames and sparks,
static electricity, spark, moisture
Incompatibility with other materials: Alkaline substances, metals, strong oxidizing agents
Hazardous decomposition products:
Sulfur oxides(SOx), Carbon monoxide(CO), carbon dioxide(CO2),
Nitrogen oxides(NOx)YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
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11．TOXICOLOGICAL INFORMATION
Information as the mixture is not available.
Acute toxicity :5) Not classified
6) Tween 20 (oral, rat); LD50=37000mg/kg
Sodium chloride (oral, rat); LD50=3000mg/kg
Not classified7) Sulfuric acid (inhalation, rat); 2H LC50=510mg/m3(oral, rat) LD50=2140mg/kg
Category 4
Hazard statement; Harmful if inhaled.
Content=9.69%
Skin corrosion/irritation:5) Not classified
6) Tween 20 (skin, human); 15mg/3days, Mild
Sodium chloride (skin, rabbit); 500mg/24H, Mild
Category 3
Hazard statement; Skin irritant7) Sulfuric acid; Based on the NITE GHS classification.
Category 1AHazard statement; Causes severe skin burns and eye damage.
Content=9.69%
Serious eye damage/irritation:5) Not classified
6) Tween 20 (eye); R-phase(s) =R36 (Irritating to eyes)
Sodium chloride (eye, rabbit); 100mg/24H, Medium
Category 2B
Hazard statement; Causes eye irritation.
7) Sulfuric acid; Based on the NITE GHS classification results.
Category 1
Hazard statement; Causes serious eye damage.
Content=9.69%
Respiratory or skin sensitization:
Respiratory sensitization
5) Not classified7) Sulfuric acid; No data available.
Skin sensitization
5) Not classified7) Sulfuric acid; No data available.
Germ cell mutagenicity:5) Not classified7) Sulfuric acid; No data available.

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
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Carcinogenicity:5) Not classified7) Sulfuric acid; Occupational exposure to Mist of inorganic strong acids
including sulfuric acid is classified to group 1 in IARC (to havecarcinogenicity for human ), group A2 in ACGIH (suspected humancarcinogens) and group K in
NTP (known to have carcinogenicity for human). With respect for
the evaluation by IARC and current evaluation by NTP, it should beclassified to category 1, however since sulfuric acid itself is classified
to Category 4 in DFGOT and is not classified to carcinogen by anyother organization,
component 7) cannot be classified.
Reproductive toxicity:
2) DHEA; Data not available.
5) Not classified7) Sulfuric acid; No data available.
Specific target organ systemic toxicity/Single exposure:5) Not classified7) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system
Hazard statement; Causes damage to the following organs: respiratory
Content=9.69%

system.

Specific target organ systemic toxicity/Repeated exposure:5) Not classified7) Sulfuric acid; Based on the NITE GHS classification results.
Category 1 respiratory system
Hazard statement; Causes damage to the following organs through prolonged orrepeated exposure: respiratory system.
Content=9.69%
12． ECOLOGICAL INFORMATION
Information as the mixture is not available.
Aquatic environmental toxicity/Acute phase:5) No information available.
7) Sulfuric acid; In fish (Bluegill), 96H LC50=16-28mg/L
Daphnia magna 24H EC50=29mg/L
Hazard statement; Harmful to aquatic life.
Aquatic environmental toxicity/Chronical phase:7) Sulfuric acid; Based on the NITE GHS classification results.

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
7/8

13．DISPOSAL CONSIDERATIONS
Dispose of all waste material including containers in accordance with all applicable laws and local
environmental regulations.
14．TRANSPORT INFORMATION
IATA; As a mixture, the substance is subjected to no limitations.
15． REGULATORY INFORMATIONInternational Inventories
EINECS/ELINCS
ListedTSCA
ListedJapanese regulations
Fire Service Act; Not applicable
Poisonous and Deleterious Substances Control Law; Not applicable
Industrial Safety and Health Act;
Group 3 Specified Chemical Substance, (Ordinance on Prevention of Hazards
Due to Specified Chemical Substances Art.2 Para.1, Item 6)
Harmful Substances Whose Names Are to be Indicated on the Label (Law
Art.57, Para.1, Enforcement Order Art.18)
Notifiable Substances (Law Art.57-2, Enforcement Oder Art.18-2 No.613
Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc.;
Priority Assessment Chemical Substances (Law Article 2, Para.5)
Regulations for the carriage and storage of dangerous goods in ship;
Corrosive Substances(Ordinance Art.3, Ministry of Transportation OrdinanceRegarding Transport by Ship and Storage)
Civil Aeronautics Law;
Corrosive Substances (Ordinance Art.194, MITL Nortification for Air
Transportation of Explosives etc.)
Air pollution Control Law; Specified substance
EU Directive 1999/45/EC; classification, packaging and labeling of dangerous Preparations
SYMBOL : C as component 7)
R-phrases : 35 as component 7)
S-phrases : 26-45 as component 7)
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of accident or if you feel unwell, seek medical advice immediately.
EC index No. : ⑥=259-364-6, ⑨=016-020-00-8
Other ingredients=Not listed.
Follow all the regulations in your country.

YK２90 DHEA (Saliva) EIA Kit
YANAIHARA INSTITUTE, INC.
SDS No.00290-007
June 10, 2022
8/8

16． OTHER INFORMATION
Reference
1) Internal data of Yanaihara Institute, Inc.
2) Chemwatch MSDS
3) RTECS (2006)
4) EU RAR (2003)
5) SIDS (2001)
6) Environmental Risk Assessment of Chemicals Vol.3 (Ministry of environment, Japan) (2004)
7) ATSDR (1998)
8) SIDS (2001)
9) DFDS (2001)
10) EU- RAR (2002)
11) SIDS (2003)
12) CERI・NITE Hazard Assessment Report (2005)
13) NTP DB (Access on Dec., 2005)
14) Narotsky and Kavlock (1995)
15) EHC 161 (1994)16) MSDS by Wako Pure Chemical Industries, Ltd.
17) ECETOC JACC (1993)
18) ACGIH (2001)19) NITE Biodegradation and Bioconcentration of the Existing Chemical Substances
20) PHYSPROP Database (2005)21) IUCLID (2000)
22) HSDB (2006)23) JSOH Recommendation of Occupational Exposure Limits (1993)24) IARC (1992)
25) ACGIH (2004)
Key literature references and sources for data etc.;
NITE: National Institute of Technology and Evaluation (JAPAN) http://www.safe.nite.go.jp/japan/db.html IATA
dangerous Goods Regulations RTECS: Registry of Toxic Effects of Chemical Substances Japan Industrial
Safety and Health Association GHS Model SDS Dictionary of Synthetic Organic Chemistry, SSOCJ, Koudansha
Scientific Co.Ltd. Chemical Dictionary, Kyouritsu Publishing Co., Ltd. etc.
The above information is believed to be correct to be the best of our knowledge and information,
but does not purport to be all inclusive and should be used as only a guide. This product is intended to be usedby expert persons having chemical knowledge and skill, at their own discretion and risk.
Yanaihara institute shall not be held liable for any damages resulting from handling or contact with the above
product.
Users should determine the suitability of the information for their particular purpose.