Marine Placenta®

Cosmetics andQuasi-drugs material

Marine Placenta is products that are extracted and purified from salmon ovary membrane using an innovative method developed by Nippon
Barrier Free.
Marine Placenta is a raw material used in cosmetics and quasi-drugs. It has a low molecular weight, and contains amino acids and mucopolysaccharide.

Cell activation test using
human dermal fibroblast

Skin elasticity[Suction recovery rate](variation): p<0.05

（％）

0.04

105
100

0.02

95

090

Variation（Week2 - Week0）

Test duration : 2 weeksPercentage of active ingredient : 1%
Number of people : 12 people in each group(women aged 40 ± 2 years, double blind method)
Measurement : Cutometer【 Po r e s 】【 St ains 】

V isibly dar k por e s

642Control

Marine Placenta

Skin(Change of texture)【 W ri n k l e s 】

Vi s i b l y d a r k p o res

80

Control Marine Placenta

Skin(Change in pores, wrinkles and stains): p<0.0110(μg/mg protein)

1100.06

Accelerating action on type I collagensynthesis in human ﬁbroblasts: p<0.05

115Marine Placenta formulation
cosmetics group
Control group↑Improvement

0.1
0.08

Activation of human dermal ﬁbroblasts

Type I collagen synthesis

V e ry n o t i c e a b l e s t a i n s

Texture coeﬃcient [mid-cheek area](variation)
Deterioration

Skin(Skin elasticity)

0.1
0.05
0: p<0.05
Marine Placenta formulation
cosmetics group
Control groupstart
Total length 50mm /total surface area 103㎟

After 8 weeks

After 2 weeks

After 2 weeks

1 / 4㎟

Test duration : 2 weeks and 8 weeks
Percentage of active ingredient : 1%
Number of people : 12 people in each group (women aged 40 ± 2 years, double blind method)
Measurement : Robo skin analyzer◎Safety Data

・Skin primary irritation test・Two-week continuous skin irritation test
・Eye irritation test・Skin sensitization test・Reverse mutation test
・Human skin irritation test・Single oral dose toxicity test・Photosensitivity test・Phototoxicity test・Chromosome aberration test

◎Evidence· Skin test (skin elasticity, texture, dark pores improvement etc.）· Test of hair growth (promotion of hair growth)· Cell activation test using human dermal fibroblast· Type I collagen synthesis test using human dermal fibroblast· Antioxidant action-0.2

Variation（Week2 - Week0）

10.5: p<0.01
Marine Placenta formulation
cosmetics group
Control group0

Total length 40mm /total surface area 0㎟47-0.1-0.15

Texture score[mid-cheek area](variation)

5 / 13㎟
Deterioration

352

Improvement

start

start

Improvement-0.05-0.5-1

Variation（Week2 - Week0）

Test duration: 2 weeks
Percentage of active ingredient: 1%
Number of people: 12 people in each group(women aged 40 ± 2 years, double blind method)
Measurement: Direct skin sensor◎Patent· Cosmetic (Patent No. 3981397: Japan)… Histamine release inhibition (anti-allergic effect)· Cosmetic (Patent No. 4005113: Japan)… Melanin production inhibition (whitening)· Hair restorer (Patent No. 4643754: Japan)· Dark pore improving agent (Patent No. 4792588: Japan)· Cosmetic (Patent No. 10-1450681: Korea)… suppression of histamine release, suppression of melanin production, improvement of dark pores, increase of sebum· Cosmetic (Patent No. ZL 2007 1 0302064.7: China)… inhibition of histamine release, inhibition of melanogenesis, darkening of poresMarine Placenta is a registered trademark of Nippon Barrier Free Co., Ltd.
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* Please follow the related laws and regulations when displaying or advertising cosmetics that contain our products.

The Science of Salmon

TM

Nippon Barrier Free Co., Ltd.

Surugadaishita MK Buld. 4F, 1-41, Kanda Jimbo-cho, Chiyoda-ku,Tokyo 101-0051, JAPAN
TEL:+81-3-5283-7222 FAX:+81-3-5283-7221 URL:https://www.n-bf.co.jp E-mail:eigyou@n-bf.co.jp
Rev. April 2021