YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
1/10

Safety Data Sheet
１． PRODUCT AND COMPANY IDENTIFICATION
Product Name:
Product number:
Manufacturer:

Cortisol (Saliva) EIA Kit / New type
YK241
YANAIHARA INSTITUTE, INC.
Address: 2480-1, Awakura, Fujinomiya-shi

Shizuoka, Japan 418-0011
Tel: +81-544-22-2771(Japan)
Fax: +81-544-22-2770
E-mail:ask@yanaihara.co.jp
First issue: Nov. 27, 2023
２． HAZARDS IDENTIFICATIONGHS classification
Classification of the substance or mixture 7)
Acute toxicity - Inhalation (Dusts/Mists)
Skin corrosion/irritation
Serious eye damage/eye irritation
Specific target organ toxicity (single exposure)
Category 1 respiratory system
Specific target organ toxicity (repeated exposure)
Category 1 respiratory system

Category 4
Category 1
Category 1
Category 1
Category 1

Pictograms

Signal word
DangerHazard statements
H314 - Causes severe skin burns and eye damage
H318 - Causes serious eye damage
H332 - Harmful if inhaled
H370 - Causes damage to the following organs: respiratory system
H372 - Causes damage to the following organs through prolonged or repeated exposure: respiratory
systemYK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
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Precautionary statements-(Prevention)
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fumes/gas/mist/vapors/spray.
Wash face, hands and any exposed skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Precautionary statements-(Response)
IF SWALLOWED: Rinse mouth. Do not induce vomiting.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin withwater/shower.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
Wash contaminated clothing before reuse.
Precautionary statements-(Storage)
Store locked up
Store in a well-ventilated place. Keep container tightly closed.
Precautionary statements-(Disposal)
Dispose of contents/container to an approved waste disposal plant
OthersOther hazards

Not available

Other reagents may be harmful if inhaled and ingested.

May cause eye and skin irritation.

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
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３． COMPOSITION, INFORMATION ON INGREDIENTS
Product Name
Cortisol (saliva) EIA Kit / New type

CAS Number
None

Kit components:
No.

Component

Quantity

Chemical name

Wt%

1)

Antibody Coated Plate

1 plateMonoclonal anti-cortisol antibodies ①

2)

Cortisol Standard

0.12 g

Synthetic cortisol ②

3)

HRP-labeled Cortisol

0.15 mL

HRP conjugated cortisol ③

4)

Buffer Solution

30 mL

BSA-containing PBS buffer④

<0.1%

BSA⑤
5)

TMB Substrate

12 mL

3,3’,5,5’-Tetramethylbenzidine ⑥

6)

Wash Solution(concentrated)

50 mL

Sodium chloride ⑦

0.1%
No
information
18%

7)

Reaction Stopping Solution

12 mL

8)

Adhesive Foil

2 sheets

CAS No.

Chemical Formula

50-23-7

C21H30O5

7558-80-7

NaH2PO4

54827-17-7

C16H20N2

7647-14-5

NaCl

Polyoxyethylene sorbitan monolaurate (Tween20)⑧

1%9005-64-5

C58H114O26

Sulfuric acid (1M) ⑨

9.69%

7664-93-9

H2SO4

４． FIRST AID MEASURES
Inhalation:
Immediately remove victim to fresh air. Consult a physician if necessary.
Eye contact: Immediately flush eyes with flooding amounts of running water for at least 15
minutes. Consult a physician if necessary.
Skin contact: Immediately remove contaminated clothes and shoes, flush skin with plenty ofwater or shower. Wash contaminated clothing and shoes.
Consult a physician if necessary.
Ingestion:
Immediately seek medical attention.
５． FIRE FIGHTING MEASURES
Flammable properties:
Nonflammable
Extinguishing media:
Foam, Carbon dioxide, dry chemical powder, soil, water.
Fire fighting instructions:
May emit toxic fumes under fire conditions. Wear full fire fighting
protective equipment including self-contained breathing apparatus.
Do not contact to the components when extinguish fire.
６．ACCIDENTAL RELEASE MEASURES
Personal precautions:Remove all ignition sources and ventilate. Wear suitable protective equipment.
Avoid contact with skin and eyes. Keep off except persons concerned.
Environmental precautions: Prevent spills from entering sewers, watercourses or low area, and prevent from
affecting environment.
Methods for Clean up:
In case of spill of liquid material, take up or cover spilled material with ashes orother incombustible absorbents, and put in a container to be sealed. Aftercompletely picked up, dispose. In case of spill of solid or powder material,
prevent causing dust, sweep and collect, and put in a container to be sealed.

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
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Wash the spill site with water.
７．HANDLING AND STORAGE
Handling:

Storage:

Obtain a package insert before use.
Read all the cautions for safety in the package insert before use.
Avoid strong light.
Avoid contact, inhalation and swallow.
Use only in open air or ventilated area.
Prevent from entering eyes.
Ventilate the area to keep concentration in air below exposure limits.
Avoid inhalation of mist, vapor and spray of material.
Avoid contact with eyes, skin and clothing.
Do not smoke and eat while using this kit.
Wash hands thoroughly after handling.
Prevent from entering environment.
Handle materials with suitable protection.
Use suitable equipments.
Do not pipette by mouth.
Do not leak, overflow and scatter.
Do not fall down and damage.
Store away from sunlight in a cool and dark place at 36-47ﾟF (2-8ﾟC).

８．EXPOSURE CONTOROLS, PERSONAL PROTECTION
Engineering measures: General ventilation and/or local exhaust ventilation as well as process isolation isnecessary to minimize employee exposure and maintain exposure limits below exposure
limits. Equip eye flushing facilities and shower rooms near operating place where thiskit is handled or stored.
Control parameter:⑨ OSHA Final Limits;
JSOH (Japan);
ACGIH TLV(s);TWA= 1 mg/m3
TWA= 1 mg/m3
TWA= 0.2 mg/m3

Personal protection:
Respiratory protection; NIOSH and MSHA approved respirator.
Hand protection;
Suitable impervious gloves.
Eye protection;
Suitable safety glasses (goggles).
Skin protection;
Suitable protective clothing.
Others:Wash hands thoroughly after handling materials.

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
5/10

９． PHYSICAL AND CHEMICAL PROPERTIES
Component

1)

2)

3)

4)

5)

6)

7)

8)

Appearance

Colorless plate

White color,lyophilized
powderOrange color,
LiquidColorlesstransparent,
LiquidColorless to paleyellow liquid

Colorlesstransparent ,LiquidColorlesstransparent,
LiquidColorlesstransparent
Polymersheet

pHMelting point

N/A
N/A

N/A
D/N/A

N/A
N/A

7.1
N/A

3.3-3.8
N/A

D/N/A
N/A

<1.0
N/A

N/A
N/A

Boiling point

N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Flash point

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Explosive limits

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Vapor pressure

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Vapor density(air=1)

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Specifics gravity

D/N/A

D/N/A

D/N/A

D/N/A

1.01

D/N/A

D/N/A

D/N/A

Solubility in water

Insoluble

SolubleMixableMixableMixableMixableMixableInsoluble

Decomposition
temperature

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

N/A: Not applicable
D/N/A: data not available

10． STABILITY AND REACTIVITY
Chemical stability:
Shelf life:
Hazardous polymerization:
Conditions to avoid:

Product is stable under normal handling.
Stable up to 18 months (temporary) after manufacturing.
Will not occur.
Extremes of temperature and direct sunlight, heat, flames and sparks,
static electricity, spark, moisture
Incompatibility with other materials: Alkaline substances, metals, strong oxidizing agents
Hazardous decomposition products:
Sulfur oxides(SOx), Carbon monoxide(CO), carbon dioxide(CO2),
Nitrogen oxides(NOx)11．TOXICOLOGICAL INFORMATION
Information as the mixture is not available.
Acute toxicity:5) Not classified
6) Tween 20 (oral, rat); LD50=37000mg/kg
Inhalation (rat); >5.1mg/L, 4h7) Sulfuric acid (inhalation, rat); 4h LC50=347ppm(Oral, rat) LD50=2140mg/kg
Acute toxicity (Oral) Category 5
Acute toxicity (Inhalation: Dusts and mists) Category 2⑨Content=9.69% Acute toxicity (Inhalation: Dusts and mists) Category 3
Skin corrosion/irritation:5) Not classified
6) Tween 20 ; No information available7) Sulfuric acid; Category 1⑨Content=9.69% Category 1

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
6/10

Serious eye damage/irritation:5) Not classified
6) Tween 20 ; No information available7) Sulfuric acid; Category 1⑨Content=9.69% Category 1
Respiratory or skin sensitization:
Respiratory sensitization
5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Classification not possible
Skin sensitization
5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Not classified
Germ cell mutagenicity:5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Classification not possible
Carcinogenicity:5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Occupational exposure to Mist of inorganic strong acids
including sulfuric acid is classified to group 1 in IARC (to havecarcinogenicity for human ), group A2 in ACGIH (suspected humancarcinogens) and group K in NTP (known to have carcinogenicity forhuman). With respect for the evaluation by IARC and current
evaluation by NTP, it should be classified to category 1, however
since sulfuric acid itself is classified to Category 4 in DFGOT and is
not classified to carcinogen by any other organization,
Classification not possible
Reproductive toxicity:5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Not classified
Specific target organ systemic toxicity/Single exposure:5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Category 1 (Respiratory system)⑨Content=9.69% Category 2

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
7/10

Specific target organ systemic toxicity/Repeated exposure:5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Category 1 (Respiratory system)⑨Content=9.69% Category 2
Aspiration hazard:
5) Not classified
6) Tween 20; No information available7) Sulfuric acid; Category 1 (Respiratory system)⑨Content=9.69% Category 2
12． ECOLOGICAL INFORMATION
Information as the mixture is not available.
Aquatic environmental toxicity/Acute phase:5) No data available.
6)Tween 20; No information available7) Sulfuric acid; 96h LC50=16-28mg/L for fish (Lepomis macrochirus)
Category 3⑨Content=9.69% Not classified
Aquatic environmental toxicity/Chronical phase:5) No data available.
6) Tween 20; No information available7) Sulfuric acid; 24h LC50=29mg/L for crustacea (Daphnia magna)
Category 1⑨Content=9.69% Not classified
Persistence and degradability:
5) No additional information available
6) Tween 20; No information available7) Sulfuric acid; No information available
Bioaccumulative potential:
5) No additional information available
6) Tween 20; No data available7) Sulfuric acid; No information available
Mobility in soil:
5) No additional information available
6) Tween 20; No information available7) Sulfuric acid; No information available
Hazard to the ozone layer:
5) No additional information available
6) Tween 20; No information available

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
8/10

7) Sulfuric acid; Classification not possible
13．DISPOSAL CONSIDERATIONS
Dispose of all waste material including containers in accordance with all applicable laws and local
environmental regulations.
14．TRANSPORT INFORMATION
IATA: As a mixture, the substance is subjected to no limitations.
ADR/RID

Sulfuric acidUN number

UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Marine pollutant

8IINot applicable

IMDG
UN number

Sulfuric acid
UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Marine pollutant

8IINot applicable

Transport in bulk according to Annex II of
MARPOL 73/78 and the IBC CodeNo information available

IATA
UN number

Sulfuric acid
UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Environmentally Hazardous
Substance

8II
Not applicableYK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
9/10

15． REGULATORY INFORMATIONInternational Inventories
EINECS/ELINCS
TSCA⑨Listed⑨ListedFire Service Act;Not applicable

Poisonous and Deleterious Substances Control
Law;

Not applicable

Industrial Safety and Health Act;

⑨Harmful Substances Whose Names Are to be
Indicated on the Label (Law Art.57, Para.1,
Enforcement Order Art.18)⑨Notifiable Substances (Law Art.57-2, Enforcement
Oder Art.18-2) No.613⑨Group 3 Specified Chemical Substance, (Ordinanceon Prevention of Hazards Due to Specified Chemical
Substances Art.2 Para.1, Item 6)

Act on the Evaluation of Chemical Substances
and Regulation of Their Manufacture, etc.;

Not applicable

Regulations for the carriage and storage of
dangerous goods in ship;⑨Corrosive Substances(Ordinance Art.3, Ministry ofTransportation Ordinance Regarding Transport by Shipand Storage)

Civil Aeronautics Law;

⑨Corrosive Substances(Ordinance Art.194, MITL
Notification for Air Transportation of Explosives etc.)

Marine Pollution Prevention Law;

⑨Enforcement ordinance Appendix No. 1 Noxious
liquid substance Category Y

Act on Confirmation, etc. of Release Amounts ofSpecific Chemical Substances in the Environment
and Promotion of Improvements to theManagement Thereof (Pollutant Release andTransfer Register Law/ PRTR)；
Water Pollution Control Act；

Not Applicable

Export Trade Control Order；

Not applicable

Air Pollution Control Law;

⑨Specified substance⑨Specified substances(Law Art.2 Para.4, Enforcement
Order Art.3-3)

YK241 Cortisol (Saliva) EIA Kit / New type
YANAIHARA INSTITUTE, INC.
SDS No.00241-001
Nov 27, 2023
10/10

16． OTHER INFORMATION
Reference and abbreviation
1)
2)
3)
4)
5)
6)

Internal data of Yanaihara Institute, Inc.
RTECS : Registry of Toxic Effects of Chemical Substances.
NTP DB (Access on Dec., 2005), National Toxicology Program
SDS by FUJI FILM Wako Pure Chemical Corporation
ACGIH(2004); American Conference of Governmental Industrial Hygienists
JSOH : Japanese Society of Occupational Health
Recommendation of Occupational Exposure Limits (2021-2022)
7) NIOSH: National Institute of Occupational Safety and Health8) MSHA: Mine Safety and Health Administration
9) DFGOT; Occupational Toxicants: Critical Data Evaluation for MAK Value and Classification of Carcinogens,Vol. 15, 2001
10) SDS by Bio-Rad laboratories, Life Science GroupKey literature references and sources for data etc. ;NITE: National Institute of Technology and Evaluation (JAPAN) http://www.safe.nite.go.jp/japan/db.html IATA
dangerous Goods Regulations RTECS: Registry of Toxic Effects of Chemical Substances Japan Industrial
Safety and Health Association GHS Model SDS Dictionary of Synthetic Organic Chemistry, SSOCJ, Koudansha
Scientific Co.Ltd. Chemical Dictionary, Kyouritsu Publishing Co., Ltd. etc.
The above information is believed to be correct to be the best of our knowledge and information,
but does not purport to be all inclusive and should be used as only a guide. This product is intended
to be used by expert persons having chemical knowledge and skill, at their own discretion and risk.
Yanaihara institute shall not be held liable for any damages resulting from handling or contact withthe above product. Users should determine the suitability of the information for their particularpurpose.