The 2nd International Symposium on REPLICATION of NON GENOME

Cutting Edge of Epigenetics
共催：東京大学医科学研究所 国際共同利用・共同研究拠点

Date & Time：June 21 (Wed) 10:00 ‒ 18:00 - June 22 (Thu) 9:30 ‒ 15:00, 2023
Venue: Tsuki-no-Sumika, Atami Juraku Hotel, Shizuoka, Japan
Language: English
Organizer: Makoto Nakanishi (The University of Tokyo, Japan)

June 21 (Wed) 10:00 – 18:00
10:00 – 10:05
Makoto Nakanishi (The University of Tokyo, Japan) Opening remarks
Session 1 Epigenetics in Gametogenesis & Development
Chair: Shihori Yokobayashi, Hitomi Matsuzaki
10:05 ‒ 10:35
Masato Ikawa (Osaka University, Japan)
Testis-enriched genes and their functions for spermatogenesis and fertilization
10:35 ‒ 11:00
Akihiko Sakashita (Keio University, Japan)
The role of retrotransposon MERVL in regulating host gene expression and ontogeny
11:00 – 11:15: Coffee BreakSession 2 Epigenetics in Chromatin Regulation PartI
Chair: Hiroshi Ochiai, Takayuki Hoshii
11:15 ‒ 11:45
Takashi Fukaya (The University of Tokyo, Japan)
Visualization of transcription hubs in living Drosophila embryos
11:45 ‒ 12:20
Huck Hui Ng (Genome Institute of Singapore, Singapore)
Dissecting the genetic and epigenetic pathways for non-alcoholic fatty liver diseases
12:20 – 13:35
LunchSession 3 Epigenetics in Chromatin Regulation PartII
Chair: Atsushi Iwama, Yota Murakami
13:35 ‒ 14:10
Anja Groth (University of Copenhagen, Denmark)Chromatin Replication and Epigenome Maintenance114:10 ‒ 14:40
Katsuhiko Shirahige (The University of Tokyo, Japan)
Is Cohesin Really Necessary for Transcription? Molecular Entities of Transcriptional Dysregulationin the absence of Cohesin
14:40 – 15:00 Coffee Break
15:00 ‒ 15:30
Yoichi Shinkai (RIKEN, Japan)
Epigenetic plasticity safeguards heterochromatin configuration
15:30 ‒ 16:05
William J. Greenleaf (Stanford University, USA)
Exploring the physical genome
16:05 ‒ 16:10
Comments from the Advisory BoardGroup photo
16:10 – 18:00
Poster session
19:00 ‒Dinner & Reception2June 22 (Thu) 9:30 - 15:00
Session 4 Epigenetics in Transcriptional Regulation
Chair: Hiroyuki Aburatani, Mitsuhiro Endoh
9:30 ‒ 9:55
Haruhiko Koseki (RIKEN, Japan)
Polycomb in DNA damage response
9:55 ‒ 10:30
Kristian Helin (The institute of Cancer Research, UK)
Interrogating the functional roles of histone methylation in transcription
10:30 – 11:00 Coffee BreakSession 5 Epigenetics in DNA Methylation
Chair: Motoko Unoki, Taiko To
11:00 ‒ 11:25
Atsushi Iwama (The University of Tokyo, Japan)
TOPORS ubiquitin ligase promotes DNMT1 degradation upon DNA hypomethylating agents
11:25 ‒ 11:50
Kyohei Arita (Yokohama City University, Japan)
Structural basis for activation mechanism of DNMT1
11:50 ‒ 12:15
Makoto Nakanishi (The University of Tokyo, Japan)
Molecular mechanism of replication-uncoupled maintenance DNA methylation
12:15 ‒ 13:45
Lunch
Session 6 Epigenetics in Germ Line Stem Cell Biology
Chair: Akihiko Sakashita, Naoko Hattori
13:45 ‒ 14:10
Kei-ichiro Ishiguro (Kumamoto University, Japan)
Mechanism of cell cycle switch from mitosis to meiosis in mouse germ cells
14:10 ‒ 14: 45
Xin Chen (Johns Hopkins University, USA)
Breaking Symmetry: Asymmetric Histone Inheritance
14:45 – 14:55
Comments from the Advisory Board
14:55 ‒ 15:00
Hiroyuki Aburatani (The University of Tokyo, Japan) Closing remarks

3June 21 (Wed) 16:10 – 18:00
Poster session
1.

Tomohiko Akiyama (Yokohama City University)
Mechanism for regulating pluripotency by a limited number of enhancers

2.

Kazumasa Aoyama (The University of Tokyo)
The regulatory mechanism of EZH1 essential for the maintenance of EZH2-deficient
myelodysplastic syndromes (MDS)3.

Mitsuhiro Endoh (Kumamoto University)
Dppa2/4-Pcgf6 axis epigenetically primes de novo DNA methylation target genes in naïve
pluripotency for developmental fidelity

4.

Naoko Hattori (Hoshi University)
Chromodomain Y-like 2 (Cdyl2) is involved in the precise H3K9me3 patterning in mouseembryonic stem cells

5.

Takayuki Hoshii (Chiba University)
BOD1L facilitates chromatin binding of SETD1A and promotes leukemia cell growth

6.

Junko Kanoh (The University of Tokyo)
Evolution of telomere-adjacent regions in primates

7.

Kazumitsu Maehara (Kyushu University)
Stability analysis of high-dimensional dynamics using single-cell data

8.

Hitomi Matsuzaki (Tsukuba University)
Investigation of asymmetric DNA methylation formation ability of the ICR sequences usingtransgenic mice

9.

Yota Murakami (Hokkaido University)
Anti-silencing factor promotes heterochromatin formation on repeated sequences

10. Yosuke Nagahata (Kyoto University)
Evolutionary reversion to eukaryotic unicellular ancestors in tumorigenesis
11. Mariko Sasaki (National Institute of Genetics)
Understanding mechanisms by which CAF-1 functions to maintain the copy number of rDNA
repeats in budding yeast
12. Michiaki Sato (The University of Tokyo)
Analysis of the mechanism of acute myeloid leukemia maintenance by DNMT3A mutation
13. Hiroaki Tachiwana (Cancer Institute)
An HDAC inhibitor suppresses transcription of breast cancer specific genes
14. Tatsuro Takahashi (Kyushu University)
MutSα and Smarcad1 form a mispair-activated nucleosome remodeling complex that catalyzes
unidirectional nucleosome sliding
15. Junichiro Takano (RIKEN)
The role of PRC1 in the vicinity of replication fork4

16. Shouta Tanimoto (The University of Tokyo)
Analysis of SUMO signaling in regulating DNMT1-DNA crosslink repair
17. Ichiro Taniuchi (RIKEN)
Chemical inducible protein degradation in mice
18. Taiko To (Tokyo Institute of Technology)
Crosstalk between CG and non-CG DNA methylation drives plant epigenomic pattern formation
19. Motoko Unoki (The University of Tokyo)
Maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies
20. Shihori Yokobayashi (Kyoto University)
Understanding epigenome reprogramming in human germ cell fate using an in vitro
reconstitution system
21. Saori Yoshimura (Kumamoto University)
HSF5 plays an essential role in transcriptional regulation at the mid-late pachytene stagetransition in male meiotic prophase I5