Curriculum Vitae

Hayato Ishikawa, Professor, Ph. D. (石川勇人）
Born: Kitamoto, Saitama, Japan in 1977
Work address: Laboratory of Middle Molecular Chemistry,
Graduate School of Pharmaceutical Sciences, Chiba University
1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan
Phone: (+81)43-226-2914, FAX: (+81)43-226-2914
e-mail: h_ishikawa@chiba-u.jp
Education
Bachelor of Pharmaceutical Science.
Faculty of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Science.
(April 1995 - March 1999)
Master of Pharmaceutical Sciences.
Graduate School of Pharmaceutical Science, Chiba University. (April 1999 - March 2001)
Supervised by Professor Norio Aimi and Professor Hiromitsu Takayama.
Doctor of Philosophy
Graduate School of Pharmaceutical Sciences, Chiba University. (April 2001 - March 2004)
Supervised by Professor Norio Aimi and Professor Hiromitsu Takayama.
Research Experience
Research Associate
Department of Chemistry, The Scripps Research Institute(April 2004 – March 2006) Supervised by Professor Dale L. Boger
Assistant Professor
Department of Chemistry, The Scripps Research Institute(April 2006 – March 2007) working with Professor Dale L. Boger
Assistant Professor
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science(April 2007– March 2011) working with Professor Yujiro Hayashi
Associate Professor
Department of Chemistry, Graduate School of Science and Technology,
Kumamoto University (April 2011–2016) Principal Investigator

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Associate Professor
Department of Chemistry, Faculty of Advanced Science and Technology,
Kumamoto University (April 2016–2018) Principal Investigator
Full Professor
Department of Chemistry, Faculty of Advanced Science and Technology,
Kumamoto University (October 2018–2021)
Full Professor
Graduate School of Pharmaceutical Sciences,
Chiba University (March 2021–present)
Award
1.

2024、日本薬学会学術振興賞：The PSJ Award for Divisional Scientific Promotion

2.

2021、長瀬研究振興賞：Nagase Science Foundation Award 2021

3.

2016、Chemist Award BCA (MSD Life Science Foundation, Japan)

4.

2015、研究活動表彰（熊本大学）：Research Achievement Award from Kumamoto University

5. 2014、研究活動表彰（熊本大学）：Research Achievement Award from Kumamoto University
6.

2013、有機合成化学奨励賞（ 有機合成化学協会 ）： Incentive Award in Synthetic Organic
Chemistry, Japan7.

2013、Thieme Chemistry Journal Award 20148.

2013、研究業績表彰（熊本大学）：Research Achievement Award from Kumamoto University

9.

2011、The 2nd International Symposium on Process Chemistry 2011 (ISPC 2011) Award.

10.

2011、24th. Eisai Award in Synthetic Organic Chemistry, Japan
(第 24 回 有機合成化学協会研究企画賞：エーザイ研究企画賞）

11. 2009、22nd. Astellas Award in Synthetic Organic Chemistry, Japan
(第 22 回 有機合成化学協会研究企画賞：アステラス研究企画賞）
12. 2009、51st. Young Scientist’s Research Award in Symposium on the Chemistry of Natural
Products (Oral Presentation)（第 51 回 天然有機化合物討論会奨励賞（口頭発表））
13. 2009、第 89 回 日本化学会春季年会 若い世代の特別講演賞
14. 2008、第 94 回 有機合成シンポジウム 優秀ポスター賞

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15. Research Fellow of the Japan Society for the Promotion of Science.
(April 2001 - March 2004)
Publication List
1. New Entries in Organocatalysts from an Alkaloid library; Development of Aminal Catalysis for a
Michael Reaction Based on Calycanthine, K. Yamanishi, G. Ashihara, S. Shiomi, S. Harada*, M.
Kitajima, H. Takayama, H. Ishikawa*, Journal of the American Chemical Society, 146, 27152–27160(2024). DOI: 10.1021/jacs.4c10242
2. Indole C5-Selective Bromination of Indolo[2,3-a]quinolizidine Alkaloids via In Situ-Generated
Indoline Intermediate, G. Yoshimura, J. Sakamoto, M. Kitajima, H. Ishikawa*, Chemistry A European
Journal, 30, e202401153 (2024).
3. Bioinspired Total Synthesis of (+)-Kopsiyuunnanine B, S. Imaoka, Y. Nakashima, M. Kitajima, H.
Ishikawa*, Chemical and Pharmaceutical Bulletin, 72, 68–74 (2024).
4. Collective Total Syntheses of b-Carboline-type Monoterpenoid Indole Alkaloid Glycosides, J.
Sakamoto, D. Hiruma, M. Kitajima, H. Ishikawa*, Synlett, 35, 576–581 (2024). Invited article as a
special cluster “biomimetic synthesis".
5. Constituents of Uncaria lanosa f. philippinensis and their anti-amyloidogenic activity, M. A. Tan*, H.
Ishikawa, Natural Product Reserch, DOI: 10.1080/14786419.2023.2294481.
6. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase, Y.
Ito, H. Lu, M. Kitajima, H. Ishikawa, Y. Nakata, Y. Iwatani, T Hoshino*, Journal of Natural Products,
86, 2487–2495 (2023).
7. Total Syntheses of (–)-Silicine and (–)-20-Episilicine, Y. Ataka, M. Kitajima, H. Ishikawa*, Organic
Letters, 25, 7601-7605 (2023). Selected “Front Cover Picture”.
8. Asymmetric Total Synthesis of Senepodine F, Y. Nakashima, T. Inoshita, M. Kitajima, H. Ishikawa*,
Organic Letters, 25, 1151–1155 (2023).
9. Total Syntheses of (+)-Villocarine A, (–)-Apogeissoschizine, and (+)-Geissoschizine, J. Sakamoto, M.
Kitajima,

H.

Ishikawa*,

ChemistryA

European

Journal,29,

e202300179(2023).

Selected “Inside Cover Picture”.
10. Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides, A. Yoshidome, J. Sakamoto, M.
Kohara, S. Shiomi, M. Hokaguchi, Y. Hitora, M. Kitajima, S. Tsukamoto, H. Ishikawa*, Organic
Letters, 25, 347–352 (2023). Highlighted by “SYNFACTS DOI: 10.1055/s-0042-1751840”.
11. Rhamnogalacturonan-I as a Nematode Chemoattractant from Lotus Corniculatus L. Supergrowing Root
Culture, M. Oota, S. Toyoda, T. Kotake, N. Wada, M. Hashiguchi, R. Akashi, H. Ishikawa, B. Favery,
A. Y.-L. Tsai*, S. Sawa*, Frontiers in Plant Science, 13:1008725 (2023).
12. Pandanus

amaryllifolius Exhibits In Vitro Anti-Amyloidogenic Activity and Promotes
Neuroprotective Effects in Amyloid-β-Induced SH-SY5Y Cells, M. A. Tan, H. Ishikawa, S. S. A.
An, Nutrients, 14, 3962 (2022).
13. Asymmetric Total Synthesis of Mitragynine, Speciogynine, and 7-Hydroxymitragynine, J. Sakamoto,
M. Kitajima, H. Ishikawa*, Chemical and Pharmaceutical Bulletin, 70, 662–668 (2022).
14. Borocyclic Radicals Prepared from Orthoquinone-Containing Polycyclic Aromatics by
Photoirradiation, K. Urakawa, Y. Yatsuoka, Y. Kawabata, H. Masu, M. Matsuda*, H. Ishikawa*, The
Journal of Organic Chemistry, 87, 3747–3751 (2022).

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15. Asymmetric Total Synthesis and Structure Elucidation of Huperzine H, S. Shiomi, K. Wilailak, W.
Soutome, H. Takayama, M. Kitajima, H. Ishikawa*, The Journal of Organic Chemistry, 87, 3730–
3735 (2022). Selected “Cover Picture”.
16. Secorubenine, a Monoterpenoid Indole Alkaloid Glycoside from Adina rubescens: Isolation, Structure
Elucidation, and Enantioselective Total Synthesis, N. Nakashima, J. Sakamoto, K. Rakumitsu, M.
Kitajima, L. D. Juliawaty, H. Ishikawa*, Chemical and Pharmaceutical Bulletin, 70, 187–191(2022).
17. Bioinspired Transformations Using Strictosidine Aglycones: Divergent Total Syntheses of
Monoterpenoid Indole Alkaloids in the Early Stage of Biosynthesis, J. Sakamoto, H. Ishikawa*,
Chemistry A European Journal, 28, e202104052 (2022). Selected “Inside Cover Picture”.
18. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibitionof RANKL-Induced Formation of Multinuclear Osteoclasts, Y. Maeyama, Y. Nakashima, H. Kato, Y.
Hitora, K. Maki, N. Inada, S. Murakami, T. Inazumi, Y. Ise, Y. Sugimoto, H. Ishikawa, S. Tsukamoto*,
Journal of Natural Products, 84, 2738–2743 (2021).
19. Root-Knot Nematode Chemotaxis is Positively Regulated by L -Galactose Sidechains of Mucilage
Carbohydrate Rhamnogalacturonan-I, A. Y.-L. Tsai, Y. Iwamoto, Y. Tsumuraya, M. Oota, T. Konishi,
S. Ito, T. Kotake, H. Ishikawa, S. Sawa*, Science Advances, 7, eabh4182, (2021).

20. Calcium Sulfate and Calcium Carbonate as Root-Knot-Nematode Attractants and Possible Trap
Materials to Protect Crop Plants, S. Toyoda, M. Oota, H. Ishikawa, S. Sawa*, Plant Biotechnology,
38, 157–159 (2021).
21. Discovery, Characterization and Functional Improvement of Kumamonamide as Novel Plant
Growth Inhibitor that Disturb Plant Microtubules, T. Ishida*, H. Yoshimura, M. Takekawa, T.
Higaki, T. Ideue, M. Hatano, M. Igarashi, T. Tani, S. Sawa, H. Ishikawa*, Scientific Reports , 11 ,6077 (2021).
22. Epoxyquinophomopsins A and B from Endophytic Fungus Phomopsis sp. and Their Activity against
Tyrosine Kinase, E. Hermawati*, S. D. Ellita, L. D. Juliawaty, E. H. Hakim, Y. M. Syah, H. Ishikawa,
Journal of Natural Medicine,75, 217–222 (2021).
23. Total Syntheses of (–)-Strictosidine and Related Indole Alkaloid Glycosides, J. Sakamoto, Y.
Umeda, K. Rakumistu, M. Sumimoto, H. Ishikawa*, Angewandte Chemie, International
Edition, 59, 13414–13422 (2020).
24. 5,6-Dihydro-a-pyrones from the Leaves of Cryptocarya pulchinervia (Lauraceae), L. D.
Juliawaty*, P. N. Ra’idash, S. Abdurrahman, E. Hermawati, A. Alni, M. I. Tan, H. Ishikawa, Y.
M. Syah, Journal of Natural Medicine,74, 584–590 (2020).
25. Identification of Naturally-Occurring Polyamines as Nematode Meloidogyne incognita Attractants, M.
Oota, A. Y.-L. Tsai, D. Aoki, Y. Matsushita, S. Toyoda, K. Fukushima, K. Saeki, K. Toda, L. PerfusBarbeoch, B. Favery, H. Ishikawa*, S. Sawa*, Molecular Plants, 13, 658–665 (2020) Highlighted
in “Molecular Plant” DOI: 10.1016/j.molp.2020.03.005.
26. Diaryliodonium Salt-Mediated Intramolecular C–N Bond Formation Using Boron-Masking NHydroxyamides, M. Matsumoto, K. Wada, K. Urakawa, H. Ishikawa*, Organic Letters, 22, 781–785(2020). Selected “Cover Picture”.
27. Enantioselective Total Synthesis of the Unnatural Enantiomer of Quinine, S. Shiomi, R. Misaka, M.
Kaneko, H. Ishikawa*, Chemical Science, 10, 9433-9437 (2019).
Selected “2019 Chemical Science HOT Article Collection” and “Inside Front Cover”. Highlighted
in “RSC Chemistry World” and “Wiley ChemistryViews”

4https://www.chemistryworld.com/news/total-synthesis-of-unnatural-enantiomer-renews-interest-inquinine/4010611.article
https://www.chemistryviews.org/details/news/11101994/Total_Synthesis_of_-Quinine.html
28. Total Syntheses of (–)-Secologanin, (–)-5-Carboxystrictosidine, and (–)-Rubenine, K. Rakumitsu, J.
Sakamoto, H. Ishikawa*, Chemistry – A European Journal , 25 , 8996–9000 (2019).
29. Enantioselective

ConstructionofOctahydroquinolines

via

Trienamine-Mediated Diels-Alder

Reactions, T. Inoshita, K. Goshi, Y. Morinaga, Y. Umeda, H. Ishikawa*, Organic Letters, 21, 2903–
2907 (2019).
30. Visualization of Plastid Peptidoglycan in the Charophyte Alga Klebsormidium nitens Using a Metabolic
Labeling Method, H. Takano*, T. Tsunefuka, S. Takio, H. Ishikawa, K. Takechi, Cytologia, 83, 375–
380 (2018).
31. Two New Indolic and Quinolic Alkaloids and Other Secondary Metabolites from Mostuea
thomsonii (Loganiaceae), E. G. B. Gompe, B. M. W. Ouahouo, V. T. Sielinou, M. Tsaffack, J. Fotie,
J. C. N. Assob, H. Ishikawa, P. Mkounga*, A. E. Nkengfack, Phytochemistry Letters, 26, 154–158(2018).
32. a-Ketocarbenium Ion Derived from Orthoquinone-Containing Polycyclic Aromatic Compounds, K.
Urakawa, Y. Kawabata, M. Mastuda, M. Sumimoto*, H. Ishikawa*, Organic Letters, 20, 2534–2537(2018).
33. Total Syntheses and Stereochemical Reassignments of Mollenines A and B, S. Shiomi, K. Wada,
Y. Umeda, H. Kato, S. Tsukamoto, H. Ishikawa*, Bioorganic & Medicinal Chemistry Letters,
28, 2766–2769 (2018). Special issue “ Dale Boger: A Celebration of 65 years of Excellence ”.
34. Bioinspired Indole Prenylation Reaction in Water, S. Tanaka, S. Shiomi, H. Ishikawa*, Journalof Natural Products, 80, 2371–2378 (2017). Selected ACS Editor’s choice and most read article
6 t h in 2017.
35. Triterpenes and Coumaroyltyramide from Ochthocosmus africanus, R. V. T. Sipowo, B. Marlyse,
W. Ouahouo, H. L. D. Maza, H. Ishikawa, H. Nishino, P. Mkounga*, A. E. Nkengfack, Journalof Diseases and Medicinal Plants, 3, 12–16 (2017).
36. Triterpenoids from Seeds of Tapinanthus bangwensis, H. Maza, P. Mkounga*, S. L. Fenkam, S.
K. Sado, H. Isikawa, H. Nishino, E. A. Nkengfack, Phytochemistry Letters, 19, 23–29 (2017).
37. Acid–Mediated Aryl Migration Reaction of C–3 Aryl Substituted Pyrrolidinoindolines, S.
Tadano, H. Ishikawa*, Tetrahedron Letters, 58, 5–8 (2017).
38. New Lupan-type Triterpenoids, P. Mkounga*, H. L. D. Maza, B. M. W. Ouahouo, L. N. Tyon,
H. Ishikawa, H. Nishino, A. E. Nkengfack, Zeitschrift für Naturforschung , 71, 381–386(2016).
39. Moss Chloroplasts are Surrounded by a Peptidoglycan Wall Containing D -Amino Acids, T.
Hirano, K. Tanidokoro, Y. Shimizu, Y. Kawarabayashi, T. Ohshima, M. Sato, S. Tadano, H.
Ishikawa, S. Takio, K. Takechi, H. Takano*, The Plant Cell, 28,1521−1532 (2016). Selected“Breakthrough report and Cover Picture”.
40. Redox Switching of Orthoquinone-containing Aromatic Compounds using Hydrogen and Oxygen
Gas, K. Urakawa, M. Sumimoto, M. Arisawa, M. Matsuda*, H. Ishikawa*, Angewandte Chemie,International Edition , 55, 7432–7436 (2016).
41. Collective Synthesis and Biological Evaluation of Tryptophan-based Dimeric Diketopiperazine
Alkaloids, S. Tadano, Y. Sugimachi, M. Sumimoto, S. Tsukamoto, H. Ishikawa*, Chemistry – A

European Journal , 22, 1277–1291 (2016).

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Selected “Hot paper” and “Inside cover picture”
42. Efficient Organocatalytic Construction of C4-Alkyl Substituted Piperidines and Their Application
to the Synthesis of (+)-α-Skytanthine, S. Shiomi, E. Sugahara, H. Ishikawa*, Chemistry – A

European Journal , 21, 14758–14763 (2015).
43. pH-Driven, Reversible Epoxy Ring Opening/Closing in Graphene Oxide, T. Taniguchi*, S. Kurihara,
H. Tateishi, K. Hatakeyama, M. Konimura, H. Yokoi, M. Hara, H. Ishikawa, Y. Matsumoto*, Carbon ,85, 560–566 (2015).
44. Synthesis of Tryptophan-based Dimeric Diketopiperazine Alkaloids using Bio-inspired Reactions, S.
Tadano, H. Ishikawa*, Synlett , 25 , 157–162 (2014).
45. Organocatalyst-mediated Dehydrogenation of Aldehydes to α, β-Unsaturated Aldehydes, andOxidative and Enantioselective Reaction of Aldehydes and Nitromethane Catalyzed by
Diphenylprolinol Silyl Ether, Y. Hayashi*, T. Itoh, H. Ishikawa, Advanced Synthesis & Catalysis ,355, 3661–3669 (2013).
46. One-Pot Synthesis of (–)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael
Reaction, T. Mukaiyama, H. Ishikawa, H. Koshino, Y. Hayashi*, Chemistry – A European Journal ,19, 17789–17800 (2013).
47. Bio-inspired Dimerization Reaction of Tryptophan Derivatives in Aqueous Acidic Media: Threestep Synthesis of (+)-WIN 64821, (–)-Ditryptophenaline and (+)-Naseseazine B, S. Tadano, Y.
Mukaeda, H. Ishikawa*, Angewandte Chemie, International Edition , 52, 7990–7994 (2013).
48. Diarylprolinol in an Asymmetric Aldol Reaction of a-Alkyl-a-oxo Aldehydes as an Electrophile,
Y. Hayashi*, Y. Yasui, M. Kojima, T. Kawamura, H. Ishikawa, Chemical Communications , 48 ,4570–4572 (2012).
49. Organocatalytic, Enantioselective Intramolecular [6+2] Cycloaddition Reaction for the Formationof Tricyclopentanoids and Insight on Its Mechanism from a Computational Study, Y. Hayashi*, H.
Gotoh, M. Honma, K. Sankar, I. Kumar, H. Ishikawa, K. Konno, H. Yui, S. Tsuzuki, T. Uchimaru,

Journal of the American Chemical Society , 113, 20175–20185 (2011).
50. Spontaneous Conversion of 3-Alkyl-substituted 3-Hydroxyperoxypyrrolidine-2, 4-diones into 5Alkyl-5hydroxyoxazolidin-4-ones, M. A. Haque, H. Ishikawa, H. Nishino*, Chemistry Letters , 40 ,
1349–1351 (2011).
51. Synthesis of (–)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement, H. Ishikawa,
B. P. Bondzic, Y. Hayashi*, European Journal of Organic Chemistry , 6020–6031 (2011).
52. One-pot Synthesis of Chiral Aziridines by a Domino Reaction using Desulfonylative Formationon the N-Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key Step ,Y. Hayashi*, T. Urushima, D. Sakamoto, K. Torii, H. Ishikawa, Chemistry – A European Journal ,17, 11715–11718 (2011).
53. Asymmetric Mannich Reaction of Imines Derived from Aliphatic and Aromatic

Aldehydes

Catalyzed by Diarylprolinol Silyl Ether, T. Urushima, H. Ishikawa, Y. Hayashi*, Chemistry – A

European Journal , 17, 8273–8276 (2011).
54. Organocatalyzed Michael Addition of Aldehyde to Nitro alkenes – Generally Accepted Mechanism
Revisited and Revised, K. Patora-Komisarska, M. Benohoud, H. Ishikawa, D. Seebach*, Y. Hayashi*,Helvetica Chimica Acta , 94, 719–745 (2011).
55. Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by
Diphenylprolinol Silyl Ether, Y. Hayashi*, T. Itoh, H. Ishikawa, Angewandte Chemie,International Edition , 50, 3920–3924 (2011).

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56. Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl
Hemiacetal with Aldehyde, Y. Hayashi*, Y. Yasui, T. Kawamura, M. Kojima, H. Ishikawa, Synlett ,485–488 (2011).
57. Asymmetric, One-Pot, Four-Component Coupling Reaction for the Synthesis of Substituted
Tetrahydropyran Catalyzed by Diphenylprolinol Silyl Ether, H. Ishikawa, S. Sawano, Y. Yasui, Y.
Shibata, Y. Hayashi*, Angewandte Chemie, International Edition , 50 , 3774–3779 (2011).
58. “One-Pot” High-Yielding Synthesis of a DPP4 selective inhibitor ABT-341 via a Four Component
Coupling Reaction Using Diphenylprolinol Silyl Ether as Key Reaction Mediator, H. Ishikawa, M.
Honma, Y. Hayashi*, Angewandte Chemie, International Edition , 50 , 2824–2827 (2011). Selected“Very Important paper” and “inside cover picture”. Highlighted by Angew. Chem. Int. Ed. 50 , 3605
(2011) and Nature Chemical Biology 7 , 190 (2011).
59. One-Pot Synthesis of Chiral a-Substituted-b, g-Epoxy Aldehyde Dimethylacetal via a
Diphenylprolinol-Catalyzed Asymmetric Aldol Reaction of Chloroacetaldehyde as Key Reaction,
Y. Hayashi*, Y. Yasui, T. Kawamura, M. Kojima, H. Ishikawa, Angewandte Chemie, International

Edition , 50, 2804–2807 (2011).
60. High-Yielding Synthesis of the Anti-influenza Neuraminidase Inhibitor (—)-Oseltamivir by Two"One-Pot" Sequences, H. Ishikawa, T. Suzuki, H. Orita, T. Uchimaru, Y. Hayashi*, Chemistry – A

European Journal , 16, 12616–12626 (2010).
61. Polymeric Ethyl Glyoxylate in an Asymmetric Aldol Reaction Catalyzed by Diarylprolinol, T.
Urushima, Y. Yasui, H. Ishikawa, Y. Hayashi*, Organic Letters , 12 , 2966–2969 (2010).
62. Asymmetric Epoxidation of a-Substituted Acroleins Catalyzed by Diphenylprolinol Silyl Ether, B.
P. Bondzic, T. Urushima, H. Ishikawa, Y. Hayashi*, Organic Letters , 12 , 5434–5437 (2010).
63. One-Pot Synthesis of Chiral Bicyclo[3.3.0]octatrienes Using Diphenylprolinol Silyl Ether-Mediated
Ene-Type Reaction, H. Gotoh, H. Ogino, H. Ishikawa, Y. Hayashi*, Tetrahedron , 66 , 4894–4899(2010).
64. Enantio- and Diastereo-Selective Synthesis of Piperidines by Coupling of Four Components in a“One-Pot” Sequence Involving Diphenylprolinol Silyl Ether-Mediated Michael Reaction, T.
Urushima, D. Sakamoto, H. Ishikawa, Y. Hayashi*, Organic Letters , 12 , 4588–4591 (2010).
65. Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues,
H. Ishikawa, D. A. Colby, S. Seto, P. Va, A. Tam, H. Kakei, T. J. Rayl, I. Hwang, D. L. Boger*,

Journal of the American Chemical Society , 131, 4904–4916 (2009).
66. Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic, and Direct Michael Reactionof Nitroethanol with α, β - Unsaturated Aldehydes, H. Gotoh, D. Okamura, H. Ishikawa, Y.
Hayashi*, Organic Letters , 11 , 4056–4059 (2009).
67. Asymmetric Aldol Reaction of Acetaldehyde and Isatin Derivatives for the Total Syntheses of ent Convolutamydine E and CPC-1 and a Half Fragment of Madindoline A and B , T. Itoh, H. Ishikawa,
Y. Hayashi*, Organic Letters , 11 , 3854–3857 (2009).
68. Total Synthesis and Determination of the Absolute Configuration of FD-838, a Naturally Occurring
Azaspirobicyclic Product, Y. Hayashi*, K. Sankar, H. Ishikawa, Y. Nozawa, K. Mizoue, H. Kakeya,

Bioorganic & Medicinal Chemistry Letters , 19, 3863–3865 (2009). Special issue “Tetrahedron

Young Investigator Award 2009: C. F. Barbas, III”.
69. Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic Michael Reaction for
the Formation of α, α- Disubstituted α-Amino Acid Derivatives, Y. Hayashi*, K. Obi, Y. Ohta, D.
Okamura, H. Ishikawa, Chemistry – An Asian Journal , 4 , 246–249 (2009).

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70. High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three"One-Pot" Operations, H. Ishikawa, T. Suzuki, Y. Hayashi*, Angewandte Chemie, International

Edition , 48, 1304–1307 (2009). Highlighted in Nature 457 , 239 (2009).
71. Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition
Reaction via a Domino Michael/Knoevenagel Condensation, Y. Hayashi*, M. Toyoshima, H. Gotoh,
H. Ishikawa, Organic Letters , 11 , 45–48 (2009).
72. Asymmetric, Catalytic, and Direct Self-Aldol Reaction of Acetaldehyde Catalyzed by Diarylprolinol,
Y. Hayashi*, S. Samanta, T. Itoh, H. Ishikawa, Organic Letters , 10 , 5581–5583, (2008).
73. Direct Organocatalytic Mannich Reaction of Acetaldehyde: An Improved Catalyst and Mechanistic
Insight from a Computational Study, Y. Hayashi*, T. Okano, T. Itoh, T. Urushima, H. Ishikawa, T.
Uchimaru, Angewandte Chemie, International Edition , 47 , 9053–9058 (2008).
74. The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug, Y.
Hayashi*, M. Shoji, H. Ishikawa, J. Yamaguchi, T. Tamura, H. Imai, Y. Nishigaya, K. Takabe, H.
Kakeya, H. Osada, Angewandte Chemie, International Edition , 47 , 6657–6660 (2008).
75. Asymmetric Diels-Alder Reactions of a,b-Unsaturated Aldehydes Catalyzed by a Diarylprolinol
Silyl Ether Salt in the Presence of Water, Y. Hayashi*, S. Samanta, H. Gotoh, H. Ishikawa,Angewandte Chemie, International Edition , 47, 6634–6637 (2008).
76. The Effectiveness of Proteinogenic Amino Acids in the Asymmetric Aldol Reaction in DMSO and
Aqueous DMSO, Y. Hayashi*, T. Itoh, N. Nagae, M. Ohkubo, H. Ishikawa, Synlett , 1565–1570(2008).
77. Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Formal Aza [3+3]Cycloaddition Reaction for the Formation of Enantioenriched Piperidines, Y. Hayashi*, H. Gotoh,
R. Masui, H. Ishikawa, Angewandte Chemie, International Edition. , 47 , 4012–4015 (2008).
78. Asymmetric Michael Reaction of Acetaldehyde Catalyzed by Diphenylprolinol Silyl Ether, Y.
Hayashi*, T. Itoh, M. Ohkubo, H. Ishikawa, Angewandte Chemie, International Edition , 47 ,
4722–4724 (2008).
79. Proline-Mediated

Enantioselective

ConstructionofTetrahydropyransviaaDominoAldol/Acetalization Reaction, D. Hazelard, H. Ishikawa, D. Hashizume, H. Koshino, Y. Hayashi*,Organic Letters , 10, 1445–1448 (2008).
80. A Diarylprolinol in an Asymmetric, Catalytic, and Direct Crossed-Aldol Reaction of Acetaldehyde,
Y. Hayashi*, T. Itoh, S. Aratake, H. Ishikawa, Angewandte Chemie, International Edition , 47 ,
2082–2084 (2008).
81. Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine: Total Synthesis of (+)- andent-(–)-Vinblastine, H. Ishikawa, D. A. Colby, D. L. Boger*, Journal of the American Chemical
Society , 130, 420–421 (2008).
82. Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reactionof Nitroalkanes with α, β -Unsaturated Aldehydes, H. Gotoh, H. Ishikawa, Y. Hayashi*, Organic

Letters , 9, 5307–5309 (2007).
83. Total Synthesis of (-)- and ent -(+)-4-Desacetoxy-5-desethylvindoline, H. Ishikawa, Dale L. Boger*,

Heterocycles , 72, 95–102 (2007). Yoshito Kishi’s special issues.
84. New Procedure to Mask the 2,3-π Bond of the Indole Nucleus and Its Application to the Preparationof Potent Opioid Receptor Agonists with a Corynanthe Skeleton, H. Takayama*, K. Misawa, N.
Okada, H. Ishikawa, M. Kitajima, Y. Hatori, T. Murayama, S. Wongseripipatana, K. Tashima, K.
Matsumoto, S. Horie, Organic Letters , 8 , 5705–5708 (2006).

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85. Total Synthesis of (-)- and ent -(+)-Vindoline and Related Alkaloids, H. Ishikawa, G. I. Elliott, J.
Velcicky, Y. Choi, D. L. Boger*, Journal of the American Chemical Society , 128 , 10596–10612(2006).
86. Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1, 3,4-Oxadiazoles, G. I. Elliott,
J. R. Fuchs, B. S. J. Blagg, H. Ishikawa, H. Tao, Z. Yuan, D. L. Boger, Journal of the American

Chemical Society , 128, 10589–10595 (2006).
87. Total Synthesis of (-)- and ent -(+)-Vindorosine; Tandem Intramolecular Diels-Alder/1,3-Dipolar
Cycloaddition of 1,3,4-Oxadiazoles, G. I. Elliott, J. Velcicky, H. Ishikawa, Y. Li, D. L. Boger*,Angewandte Chemie, International Edition , 45, 620–622 (2006). Selected “very important paper(VIP)”.
88. Partial Agonistic Effect of 9-Hydroxycorynantheidine on μ -Opioid Receptor in The Guinea- Pig
Ileum, K. Matsumoto, H. Takayama, H. Ishikawa, N. Aimi, D. Ponglux, K. Watanabe, S. Horie*, Life
Sciences , 78, 2265–2271 (2006).
89. Total Synthesis of Natural-(-)- and ent -(+)-Vindoline, Y. Choi, H. Ishikawa, J. Velcicky, G. I. Elliott,
M. M. Miller, D. L. Boger*, Organic Letters , 7 , 4539–4542 (2005).
90. Total Synthesis of Natural (+)- and ent -(-)-4-Desacetoxy-6,7-dihydrovindorosine and Natural andent-Minovine:

Oxadiazole

TandemIntramolecularDiels-Alder/1,3-Dipolar

Cycloaddition

Reaction, Z. Yuan, H. Ishikawa, D. L. Boger*, Organic Letters , 7 , 737–740 (2005).
91. Antinociception, Tolerance and Withdrawal Symptoms Induced by 7- Hydroxymitragynine, an
Alkaloid from The Thai Medicinal Herb Mitragyna speciosa, K. Matsumoto, S. Horie*, H. Takayama,
H. Ishikawa, N. Aimi, D. Ponglux, T. Murayama, K. Watanabe, Life Sciences , 78 , 2–7 (2005).
92. Indole Alkaloids of a Thai Medicinal Herb, Mitragyna speciosa, that has Opioid Agonistic Effect inGuinea-pig Ileum, S. Horie*, F. Koyama, H. Takayama, H. Ishikawa, N.Aimi, D. Ponglux, K.
Matsumoto, T. Murayama, Planta Medica , 71 , 231–236 (2005).
93. m-Chloroperbenzoic Acid Oxidation of Corynanthe-type Indole Alkaloid, Mitragynine, Afforded
Unusual Dimerization Products, H. Ishikawa, M. Kitajima, H. Takayama*, Heterocycles , 63 , 2597–
2604 (2004).
94. A New 9-Methoxyyohimbine Type Indole Alkaloid from Mitragyna africanus, H. Takayama*, H.
Ishikawa, M. Kitajima, N. Aimi, B. M. Aji, Chemical and Pharmaceutical Bulletin , 52 , 359–361(2004).]
95. Antinociceptive Effect of 7-Hydroxymitragynine in Mice: Discovery of an Orally Active Opioid
Analgesic from the Thai Medical Herb Mitragyna speciosa, K. Matsumoto, S. Horie*, H. Ishikawa,
H. Takayama, N. Aimi, D. Ponglux, K. Watanabe, Life Sciences , 74 , 2143–2155 (2004).
96. Dimerization of Indole Derivatives with Hypervalent Iodines (III): a New Entry for the Concise
Total Synthesis of rac - and meso-Chimonanthines, H. Ishikawa, H. Takayama*, N. Aimi,

Tetrahedron Letters , 43, 5637-5639 (2002).
97. Formation of an Unusual Dimeric Compound by Lead Tetraacetate Oxidation of a Corynanthe-Type
Indole Alkaloid, Mitragynine, H. Takayama*, H. Ishikawa, M. Kitajima, N. Aimi, Chemical andPharmaceutical Bulletin , 50, 960–963 (2002).
98. Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids:
Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands, H. Takayama*, H.
Ishikawa, M. Kurihara, M. Kitajima, N. Aimi, D. Ponglux, F. Koyama, K. Matsumoto, T. Moriyama,
L. T. Yamatomo, K. Watanabe, T. Murayama, S. Horie, Journal of Medicinal Chem istry , 45 , 1949–
1956 (2002).

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99. Structure Revision of Mitragynaline, an Indole Alkaloid in Mitragyna speciosa, H. Takayama*, H.
Ishikawa, M. Kurihara, M. Kitajima, S. Sakai, N. Aimi, H. Seki, K. Yamaguchi, I. M. Said, P. J.
Houghton, Tetrahedron Letters , 42 , 1741–1743 (2001).
Review
100.

天然物全合成のためのテーラーメード有機触媒反応の開発、石川勇人*、 有機合成化学協会誌（ Journal of Synthetic Organic Chemistry, Japan ） 、 82 , 473–482 (2024).

Bioinspired Total Syntheses of Secologanin-Related Natural Products; Demonstration of the101.

Power of Secologanin in the Flask, J. Sakamoto, H. Ishikawa*, Synlett , 34 , 2293–2303 (2023).
102.

光学活性キニーネの全合成、塩見慎也*、石川勇人*、 有 機 合 成 化 学 協 会 誌 （ Journal of

Synthetic Organic Chemistry, Japan ） 、 79 , 145–154 (2021).
103.

非天然型キニーネの実用的全合成を目指して、石川勇人*、有機合成化学協会誌（ Journalof Synthetic Organic Chemistry, Japan ） 、 76 , 414–417 (2018).
104.

トリプトファン由来二量体型ジケトピペラジンアルカロイド類の統一的全合成、 石川勇*

人 、有機合成化学協会誌（ Journal of Synthetic Organic Chemistry, Japan ）, 74 , 104–116 (2016).
(有機合成奨励賞受賞招待論文)
105.

Alkaloid Synthesis using Chiral Secondary Amine Organocatalysts, H. Ishikawa*, S. Shiomi,

Organic and Biomolecular Chemistry, 14, 409–424 (2016).
106.

生 物 に 倣 う イ ン ド ー ル 酸 化 反 応 を 用 い た 生 物 活 性 ア ル カ ロ イ ド の 全 合 成 , 石 川 勇 人 *、YAKUGAKU ZASSHI , 135 , 383–390 (2015).

107.

ポットエコノミーを指向した効率的天然物合成、石川勇人、林雄二郎*、月刊ファインケ

ミカル （特集号

108.

天然物合成化学の新たな展開）、 43 、6–12（2014）.

“ tert -Bytyl Diethyl Phosphonoacetate”, H. Ishikawa, Y. Hayashi*, e-EROS (Encyclopedia of

Reagents for Organic Synthesis) , 2014 , DOI: 10.1002/047084289X.rn01708.

109.

有機触媒を用いた(–)-オセルタミビルの3ポット合成、石川勇人、林雄二郎 * 、 月刊ファイ

ンケミカル、 39 、5–10 (2010)．

110.

インフルエンザ治療薬オセルタミビルの3ポット合成−ジフェニルプロリノールシリルエ

ーテル触媒を用いた全合成−、石川勇人、林雄二郎 * 、 化学と生物 、 48 、156–157（2009）.
111.

ビンドリンおよび関連アルカロイド類の全合成, 石川勇人 * , Dale L. Boger, 有機合成化学

協会誌（ Journal of Synthetic Organic Chemistry, Japan ） ,67, 123–133 (2009).

Books
112.

Modern Natural Product Synthesis , Springer, Singapore, edited by Masahisa Nakada, Keiji

Tanino, Kazuo Nagasawa, Satoshi Yokoshima eds. 2024, Chapter 9; J. Sakamoto, H. Ishikawa*,
Collective

SynthesisofSecologanin-Related

NaturalProducts.

https://link.springer.com/chapter/10.1007/978-981-97-1619-7_9
113.

New Tide of Natural Product Chemistry , Springer, Singapore, edited by Hayato Ishikawa,

Hiromitsu Takayama eds. 2023, Chapter 10; H. Ishikawa*, Collective Synthesis of Monoterpenoid
Indole Alkaloids Using Bioinspired Strategies. https://doi.org/10.1007/978-981-99-1714-3_10
114.

The Alkaloids : Chemistry and Biology , ELSEVIER Book series, Edited by

Hans-

Joachim Knölker, Vol. 80, 2017, Chapter 1. Alkaloid Synthesis using Organocatalyst, H. Ishikawa*, S.
Shiomi, pp.1–70 (2018).

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115.

書籍： 天然物の全合成（CSJカレントレビュー29） 、化学同人、「生合成を参考にした全合成」、Part II 研究最前線、5章; pp78–85、および「連続反応の基礎」Basic Concept; pp30–35、
石川勇人* (2018)116.

書籍： 有機分子触媒の開発と工業利用 （秋山隆彦監修）、シーエムシー出版、第27章 二級アミン型不斉有機触媒反応の実用化に向けた触媒量低減化とアルカロイド合成への応用、石川勇人*、pp295–304. (2018)117.

書籍：アルカロイドの科学（高山廣光編）、有機触媒を利用したアルカロイドの不斉全合成、石川勇人*、化学同人、第14章、pp 211–234 (2023).
118.

書籍： 有機分子触媒の化学（CSJカレントレビュー22） 、化学同人、有用物質（医薬品等への応用）、石川勇人*、Part II 研究最前線、18章、pp195–201 (2016).
119.

Asymmetric Synthesis II: More Methods and Applications ; Edited by Mathias Christmann,

Stefan Brase, WILEY-VCH, 2013 ; Chapter 9, pp 61–66. Total Synthesis of Oseltamivir and ABT-341
Using One-Pot Technology, H. Ishikawa, Y. Hayashi*
Others120.

好きこそものの上手なれ、石川勇人 * 、有機合成化学協会誌（MyPR）, 80 , 379– 381 (2022).

121.

熊本におけるアイラトビカズラ（マメ科）の DNA シーケンスによる種同定, 岡本竜弥、

相田光宏、石川勇人、澤進一郎、 BOTANY 、70（熊本記念植物採集会）、pp. 8－10、(2020).
122.

熊本地震からの復興と教訓、石川勇人 * 、西野宏、中島誠、小谷俊介、有機合成化学協会誌（ Journal of Synthetic Organic Chemistry, Japan ） , 75, 259– 263 (2017).

123.

“tert-Bytyl Diethyl Phosphonoacetate”, H. Ishikawa, Y. Hayashi, e-EROS (Encyclopedia of

Reagents for Organic Synthesis), 2014, DOI: 10.1002/047084289X.rn01708.

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