The 5th Awaji Forum
Scientific program

September 5, Monday
9:00 - 11:45

Training course 1-2
Shizuo Akira, Osaka, Japan"Pathogen Recognition by Innate Immunity"
Masao Mitsuyama, Kyoto, Japan"Basic study using intracellular parasitic bacteria - Its significance in the link between
bacteriology and immunology"

11:45 - 13:00 Lunch
13:00 - 17:15 Training course 3-5
Yoshiharu Matsuura, Osaka, Japan"Biological significance of nuclear localization of Flavivirus core protein"
Tomoyoshi Nozaki"Molecular Parasitology in the Post-Genome Era"
Shigeo Koyasu"Role of dendritic cells in infectious immunity"
17:45

Opening Remarks: Yasuhiko Horiguchi, Osaka, Japan

18:00 - 19:30 SymposiumⅠ

Parasitic Infections 1 (Discussion leader: T. Horii, Osaka, Japan)
Toshihiro Horii, Osaka, Japan"Clinical development of the SE36 malaria vaccine targeting the Achilles heel antigenof Plasmodium falciparum"
Takafumi Tsuboi, Ehime, Japan" Wheat germ cell-free protein synthesis system: An application for the genome-wide
screening of novel malaria transmission-blocking vaccine candidates"
Blaise Genton, Lausanne, Switzerland"Malaria Vaccines: from the laboratory to the field"
19:45 -Welcome Reception

September 6, Tuesday
9:00 - 10:00

SymposiumⅡ
Parasitic Infections 2 (Discussion leader: Y. Morita, Osaka, Japan)
Jeremy C. Mottram, Glasgow, UK"Cysteine peptidases, lysosomal function and autophagy in Leishmania"
L. David Sibley, St. Louis, USA"Mechanisms of virulence and host defense in Toxoplasmosis"

10:00 - 10:15 Coffee break
10:15 - 11:45 Symposium Ⅲ

Viral Infections 1 (Discussion Leader: Y. Kawaguchi, Tokyo, Japan)
Junichi Sakuragi, Osaka, Japan" Genome dimerization of HIV-1 and its roles for viral replication. "Kenzo Takada, Sapporo, Japan"Role of Epstein-Barr virus-encoded RNA (EBER) in oncogenesis"
Jianxin You, Boston, USA"Papillomavirus host cell interactions contributing to persistence and cancer"
11:45 - 13:00 Lunch
13:00 - 15:00 Poster session 1(Discussion for odd-numbered posters)

15:15 - 16:15 Symposium Ⅳ

Viral Infections 2 (Discussion leader: Y. Matsuura, Osaka, Japan)
Kunitada Shimotohno, Kyoto, Japan"Inhibition of HCV genome replication by cyclosporine A through the impairment ofcyclophilin B function"
Martin Schwemmle, Freiburg, Germany"Borna disease viruses encoding a phosphoprotein without an intact
amphoterine/HMG-B1 interaction site exhibits an unexpected phenotype"16:15 - 17:45 Symposium Ⅴ

Host defense and Immunity 1 (Discussion leader: H. Kikutani, Osaka, Japan)
Yong-Jun Liu, Houston, USA"PDC/IPC in anti-viral innate and adaptive immune responses"

Wayne Yokoyama, St. Louis, USA"Natural killer cell control of viral infection"
Osamu Takeuchi, Osaka, Japan"Recognition of viral infection via TLR-dependent and -independent mechanisms"
17:45 - 19:15 Dinner19:15 - 20:15 Oral Poster 1

Bacterial Infections (Discussion Leader, M. Miyake, Osaka, Japan)
Akiko Uehara, Sendai, Japan"Up-regulation of peptidoglycan recognition proteins and β-defensin 2 by synthetic
bacterial components via respective Toll-like receptors and NOD proteins in humanoral epithelial cells"
Masato Suzuki, Tokyo, Japan"CagA interaction with Crk requires for Helicobacter pylori-induced loss of celladhesion and scattering"
Kazuhisa Ouhara, Hiroshima, Japan"Staphylococcus aureus fibronectin-binding protein is a major inducer of theexpression of the Antimicrobial peptides in human keratinocyte"
Cantarelli Vlademir, Osaka, Japan"SI-RNA-mediated knockdown of cortactin or expression of various domains within
the C-terminal region of cortactin affects pedestal formation by EPEC or EHEC"
20:15 - 21:15 Oral Poster 2

Host defense and Immunity (Discussion Leader, A. Kumanogoh, Osaka, Japan)
Hiroki Yoshida, Saga, Japan"STAT3 is responsible for IL-27/WSX-1-mediated suppression of cytokine production
by activated T cells"
Noriko Takegahara, Osaka, Japan"Plexin-A1 associates with Trem-2/DAP12 receptor complex and mediates theactivities of Sema6D on DCs"
Masaji Okada, Osaka, Japan"Development of vaccines against SARS corona virus infection using mouse andSCID-PBL/hu mouse models"Jun Kunisawa, Tokyo, Japan"Roles of cytoplasmic chaperones in MHC class I presentation for vaccine design andmicrobial immunity"

September 7, Wednesday
9:00 - 10:30

Symposium Ⅵ
Autophagy 1 (Discussion leader: T. Yoshimori, Mishima, Japan)
Tamotsu Yoshimori, Mishima, Japan"Autophgy unveiled: Its molecular basis and role in diseases"
Christian Munz, New York, USA"Endogenous MHC class II antigen processing after autophagy"
Vojo Deretic, Albuquerque, USA"Autophagy as an immune effector and control of Mycobacterium tuberculosis"

10:30 - 10:45 Coffee break
10:45 - 11:45 Symposium ⅦAutophagy 2 (Discussion leader: V. Deretic, Albuquerque, USA)
Ichiro Nakagawa, Osaka, Japan" Intracellularly invaded Streptococcus pyogenes is degraded by autophagic machinery
Michinaga Ogawa, Tokyo, Japan"Escape of intracellular Shigella from autophagy"
11:45 - 13:00 Lunch
13:00 - 15:00 Poster session 2 (Discussion for even-numbered posters)
15:15 - 16:45 Symposium Ⅷ

Host defense and Immunity 2 (Discussion leader: K. Miyake, Tokyo, Japan)
Takashi Fujita, Tokyo, Japan"Induction of IFN gene expression by virus infection: Shared and unique functions ofthe DExD/H-Box helicases RIG-I, MDA5 and LGP2"
Akinori Takaoka, Tokyo, Japan"Critical role of interferon regulatory factors (IRFs) in Toll-like receptor signallings"
Trude H. Flo, Trondheim, Norway"The role of lipocalin 2 in host defense"
16:45 - 17:00 Coffee break17:00 - 18:00 Oral Poster 3

Parasitic Infections (Discussion Leader, T. Mitamura, Osaka, Japan)
Lijun Tang, Fukuoka, Japan"Induction of protective immunity against Trypanosoma cruzi by DNA vaccine with achimeric gene encoding a cytotoxic T lymphocyte epitope of trypomastigote andgreen fluorescent protein"
Kanako Komaki-Yasuda, Tokyo Japan"Analysis of mechanisms for transcriptional regulation of peroxiredoxin genes inhuman malaria parasite, Plasmodium falciparum"
Tomoko Ishino, Mie, Japan"Two proteins with 6-cys motifs are required for malarial parasites to commit toinfection of the hepatocyte"
Kumiko Nakada-Tsukui, Gunma, Japan"A retromer-like complex is a novel Rab7 effector that is involved in the transport ofthe virulence factor cysteine protease in the enteric protozoan parasite Entamoebahistolytica

18:00 - 19:00 Oral Poster 4

Viral Infections (Discussion Leader, K. Moriishi, Osaka, Japan)
Fumihiro Taguchi, Tokyo, Japan"Protease-Mediated Enhancement of SARS Coronavirus Infection"
Taro Kawai, Osaka, Japan"IPS-1: a novel adaptor that is involved in RIG-I- and Mda-5-dependent type I
interferon induction and anti-viral immune response"
Hiroki Sato, Tokyo, Japan"The N protein of measles virus inhibits translation via interaction with eIF3-p40. "Teruhito Yasui, Osaka, Japan"The modification of the B cell development by Epstein-Barr virus Latent membraneprotein 1"

19:30 -Banquet

September 8, Thursday
9:00 - 10:00

Symposium Ⅸ
Bacterial Infections 1 (Discussion leader: P. Sebo, Prague, Czech Republic)
Mary O'Riordan, Ann Arbor, USA"Role of TBK1 in innate immunity to intracellular bacterial pathogens"
Thomas Borén, Umeå, Sweden"Helicobacter pylori; adherence and vaccine"

10:00 - 10:15 Coffee break
10:15 - 11:45 Symposium Ⅹ

Bacterial Infections 2 (Discussion leader: T. Iida, Osaka, Japan)
Peter Sebo, Prague, Czech Republic"Dissecting the capacity of Bordetella adenylate cyclase to penetrate cellular
membrane, form membrane channels and paralyze host phagocytes"
Michael Gilmore, Boston, USA"Sensing mechanism for target cells by Enterococcus faecalis"Andrew Camilli, Boston, USA"The second messenger cyclic diguanylate helps mediate the switch fromenvironmental to virulence gene expression in Vibrio cholerae"

11:45 -Closing Remarks: Hiroshi Kiyono, Tokyo, Japan