COMPLETION REPORT
Influent Factors on the Effectiveness of Sumitomo Cyclotron and Synthesizer Applications for PET/CT Scans inThailand and Japan
Mr. Jessadapong Phumruamjai （+8）
Medical Physicist
Faculty of Medicine
ChiangMai University

This study aims to investigate the influence factors that effect on efficiency of PET/CT andCyclotron applications in Japan and find the potential PET tracers to produce in Thailand. An interview
with a set of questions and the closed observation on PET radiopharmaceutical manufacturing were
performed at two Japanese institutes and one Japanese hospital during June 2014. (Japan NationalCancer Center Hospital, National Center of Neurology and Psychiatry and Tokyo Metropolitan Instituteof Gerontology) and manufacturing feasibility of Sumitomo cyclotron and synthesizer model CFN
MPS-100 were studied. The findings of more effective of PET tracers’ production in Japan thanThailand are observed in this study. From the study, varieties of PET tracers produced by synthesizer
model CFN MPS-100 are used in oncology, neurology, cardiology, and psychiatry in a rate of 5
times/week, 2 times/weeks, 2 times/weeks, and 1 time/week, respectively. More than 1,200 times ofcyclotron-produced PET radiopharmaceuticals are to serve 4,800 Japanese patients per year. From theeffective radiopharmaceuticals production, the qualified PET tracers certified by Japanese law or the
local committee are generally applied for clinical diagnosis with satisfied clinical outcome. Regarding
the potentialities in radiopharmaceuticals production, the increasing of the research in the neurology andgerontology tracers for supporting the aging society in Japan is observed.
The main influence factors on the effectiveness radiopharmaceutical production in Japan come fromthe core knowledge and the personnel experience which greatly affect the efficiency of theradiopharmaceutical production compared to the production by the same synthesizer and cyclotron
facilities in Thailand. To catch up using the same strategy, the PET/CT and cyclotron centers in
Thailand should provide adequate practical training to staffs and encourage them in learning anddeveloping a good radiopharmaceutical. From the data analysis of the production techniques andmanufacturing observation, we designed to produce two potential radiopharmaceuticals; 11CMethionine, one of the most common and reliable radiotracer in Japan, and 11C-Raclopride in
PET/CTand Cyclotron Center Chiang Mai University. Five syntheses of 11C-Methionine wereperformed starting from 34.16+7.83 GBq 11C-CO2 (end of bombardment, EOB). At the end ofsynthesis (EOS), 5.61+1.76 GBq of pure L-[methyl-11C]-methionine was obtained, representing aradiochemical yield (non-corrected for decay) of 16.38%. When we compared the production of 11C Methionine from Japanese system with our system in the same protocol, the Japanese system has asignificant quality over our production system, because of the modification technique with the goodexperience of them. For 11C-Raclopride, the production is in process
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The influence factors on effectiveness of cyclotron and synthesizer applications can be developed by theco-operation with the excellent institute which has the cored knowledge, experiences, and potentialities
in radiopharmaceuticals production. The more efficiency the system, the more beneficial outcome thepatients. The research will also support high cost technological investment in Thailand, especially innuclear medicine.
Publication of the Results of Research Project:
Verbal Presentation (Date, Venue, Name of Conference, Title of Presentation, Presenter, etc.)- 26th February 2015, Udonthani Regional Cancer Hospital, Thai Medical Physicist Society, Influence Factors on
the Effectiveness of Sumitomo Cyclotron and Synthesizer Applications for PET/CT Scans in Thailand andJapan, Mr.Jessdapong Phumruamjai.
Thesis (Name of Journal and its Date, Title and Author of Thesis, etc.)
N/A

Book (Publisher and Date of the Book, Title and Author of the Book, etc.)
N/A2