研究業績

研究業績
論文等

毒性学
Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adultmale rats
Kobayashi S1,2, Kawano N3, Miyado K4, Ohta R, Akimoto T2, Hatakeyama T1,2, Kawaguchi M2**: Corresponding author
1

Organization for the Strategic Coordination of Research and Intellectual Property, Meiji

University, 2 Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji
University, 3 Lab of Regulatory Biology, School of Agriculture, Meiji University, 4Department ofReproductive Biology, National Research Institute for Child Health and Development
J. Vet. Med. Sci., 2022; 84: 153-156, https://doi.org/10.1292/jvms.21-0046
Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously
hypertensive rats
Tatematsu K 1*, Miyazawa D 2, Saito Y, Okuyama H2, Ohara N2*: Corresponding author1

Department of Radiochemistry, Gifu Pharmaceutical University, 2 Open Research Center for

Lipid Nutrition, Kinjo Gakuin University College of Pharmacy
Lipids Health Dis, 2021; 20: 102, https://doi.org/10.1186/s12944-021-01540-7
Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma
aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP)
Nishikawa M1, Ohara N 1*, Naito Y 2, Amma C 1, Saito Y, Tatematsu K 3, Baoyindugurong J 4,Miyazawa D 1, Hashimoto Y 5, Okuyama H 1*: Corresponding author
1

College of Pharmacy, Kinjo Gakuin University, 2 School of Allied Health Sciences, Kitasato

University, 3 Gifu Pharmaceutical University, 4 College of Food Science and Engineering, Inner
Mongolia Agricultural University, 5School of Dentistry, Aichi-Gakuin University
Fundam. Toxicol. Sci., 2022; 9: 7-16
Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not infemale stroke-prone spontaneously hypertensive rats (SHRSP)
Nishikawa M 1, Ohara N 1* , Naito Y 2, Saito Y, Amma C 1, Tatematsu K 3, Baoyindugurong J 4,Miyazawa D 1, Hashimoto Y 5, Okuyama H1*: Corresponding author
1

College of Pharmacy, Kinjo Gakuin University, 2 School of Allied Health Sciences, Kitasato

University, 3 Gifu Pharmaceutical University, 4 College of Food Science and Engineering, Inner
Mongolia Agricultural University, 5 School of Dentistry, Aichi-Gakuin UniversityToxicol. Rep., 2022; 9: 256-268
26

研究業績

環境毒性学
Toxicological effects of Tris (1,3-dichloro-2-propyl) phosphate exposure in adult male rats
differ depending on the history of exposure in the neonatal period
Akimoto T1, Kobayashi S1,2, Nakayama A1, Isobe A1, Abe K1, Hatakeyama T1,2, Ohta R, Yanagisawa
R3, Koike E4, Suzuki N4, Kawaguchi M1
1

Lab of Animal Behavior and Environmental Science, School of Agriculture, Meiji University,

2Organization for the Strategic Coordination of Research and Intellectual Property, Meiji

University, 3 Health and Environmental Risk Division, National Institute for Environmental
Studies, 4 Planning Division, National Institute for Environmental Studies Correspondence
Maiko Kawaguchi
J. Appl. Toxicol., 2022; 42: 1503-1509

形成外科学
Artificial red blood cells increase large vessel wall damage and decrease surrounding
dermal tissue damage in a rabbit auricle model after subsequent flashlamp-pumped
pulsed-dye laser treatment
Shimanouchi K 1, Rikihisa N2*, Saito Y, Iuchi K 3, Tsumura N 3, Sakai H 4, Mitsukawa N 5*: Corresponding author1

Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Hospital,2Oyumino Central Hospital, 3 Department of Imaging Sciences, Chiba University, 4 Departmentof Chemistry, Nara Medical University, 5 Department of Plastic, Reconstructive, and Aesthetic
Surgery, Chiba University Graduate School of Medicine
J. Dermatol., 2021; 48: 600-612

動物実験代替法
Within- and between-laboratory reproducibility and predictive capacity of amino acidderivative reactivity assay (ADRA) using 4 mM test chemical solution: Results of ringstudy implementation from five participating laboratories
Short title
WLR, BLR and predictive capacity in ADRA (4 mM) ring study
Fujita M1*, Yamamoto Y1, Wanibuchi S1, Watanabe S2, Yamaga H2, Wakabayashi K3, Tahara Y3,
Horie N4, Fujimoto K4, Takeuchi K5, Kamiya K5, Kawakami T6, Kojima K, Sozu Takashi7, Kojima H8,Kasahara T1, Ono A9*: Corresponding author
1Fujifilm Corporation, Safety Evaluation Center, 2 Lion Corporation, Safety Science ResearchLaboratories, 3 Mitsui Chemicals, Inc., Chemical Safety Department, 4 Sumitomo Chemical Co.,
Ltd., Environmental Health Science Laboratory, 5 Nissan Chemical Corporation, BiologicalResearch Laboratories, 6 National Institute of Health Sciences, Division of EnvironmentalChemistry, 7 Tokyo University of Science, Faculty of Engineering, 8 National Institute ofHealth Sciences, Biological safety Research Center, Division of Risk Assessment, 9 Okayama
University, Graduate school of Medicine, Dentistry and Pharmaceutical sciences, Division ofPharmaceutical Sciences27

秦野研究所年報 Vol. 45. 2022

J. Appl. Toxicol., 2022; 43: 318-333
Within- and between-laboratory reproducibility and predictive capacity of amino acidderivative reactivity assay (ADRA) using a 0.5 mg/ml test chemical solution: Results ofthe study for reproducibility confirmation implemented in five participating laboratories
Short title
WLR, BLR and predictive capacity of ADRA (0.5 mg/ml)
Yamamoto Y 1*, Fujita M 1, Watanabe S 2, Yamaga H 2, Wakabayashi K 3, Tahara Y 3, Horie N 4,Fujimoto K4, Takeuchi K5, Kamiya K5, Kawakami T6, Kojima K, Sozu T7, Kojima H8, Kasahara T1,Ono A9*: Corresponding author
1Fujifilm Corporation, Safety Evaluation Center, 2 Lion Corporation, Safety Science ResearchLaboratories, 3 Mitsui Chemicals, Inc., Chemical Safety Department, 4 Sumitomo Chemical Co.,
Ltd., Environmental Health Science Laboratory, 5 Nissan Chemical Corporation, BiologicalResearch Laboratories, 6 National Institute of Health Sciences, Division of EnvironmentalChemistry, 7 Tokyo University of Science, Faculty of Engineering, 8 National Institute ofHealth Sciences, Biological safety Research Center, Division of Risk Assessment, 9 Okayama
University, Graduate school of Medicine, Dentistry and Pharmaceutical sciences, Division ofPharmaceutical Sciences
J. Appl. Toxicol., 2022; 42: 1078-1090
皮膚感作性試験代替法 Interleukin-8 Reporter Gene Assay (IL-8 Luc assay) 評価報告書
小島幸一，足利太可雄 1，安達玲子 1，佐藤一博 2，瀬崎拓人 3，武吉正博 4，福山朋季 51

国立医薬品食品衛生研究所，2 国立大学法人 福井大学，3 三井化学株式会社，4 一般財団法人 化学物質評価研究機構，5 麻布大学
AATEX-JaCVAM, 2021; 10: 49-68
Behavior of chemical respiratory sensitizers in in vitro methods for skin sensitization
Narita K, Okutomi H, Kawakami K, Sui H, Basketter D 1, Ashikaga T 2
1

DABMEB Consultancy Ltd, 2 Division of Risk Assessment, National Institute of Health Sciences

Alternatives to Animal Testing and Experimentation
AATEX, 2021; 26: 9-18

行動学
Alterations between high and low-avoidance lines of Hatano rats in learning behaviors,
ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala
Chiba S1, Okawara T2, Kawakami K2, Ohta R, Kawaguchi M2**: Corresponding author
1

Faculty of Veterinary Medicine, Okayama University of Science, 2 School of Agriculture,

Meiji University
Physiol Behav., 2022; 245: 113670, https://doi.org/10.1016/j.physbeh.2021.113670

28

研究業績

学会発表等

食品衛生学
ELISA 法による特定原材料（落花生）の測定における阻害因子の解析と改良抽出法の検討
村上太郎 1, 工藤鮎子 1, 村野晃一 1, 高取1

聡 1, 角谷直哉 1, 若栗

忍 , 渡辺卓穂

地方独立行政法人 大阪健康安全基盤研究所

日本食品化学学会

第 27 回学術大会 , 2021 年 6 月 10 日～2021 年 6 月 11 日
（Web 開催）

台所用洗浄剤における改良メタノール分析法の検討および室間共同実験
阿部裕 1, 阿部智之 2, 大野浩之 3, 大橋公泰 2, 尾崎麻子 3, 風間貴充 2, 片岡洋平 1, 鈴木公美 3, 永井慎一郎 2,花澤耕太郎 2, 早川雅人 2, 平林尚之 , 山口未来 1, 渡辺一成 2, 六鹿元雄 1, 佐藤恭子 11

国立医薬品食品衛生研究所 , 2 登録検査機関等 , 3 公的衛生研究所等

日本食品衛生学会

第 117 回学術講演会 , 2021 年 10 月 26 日～ 2021 年 11 月 2 日（Web 開催）

器具・容器包装の溶出試験における改良ビスフェノール A 分析法の室間共同実験
片岡洋平 1, 阿部智之 2, 阿部林保志 3, 佐藤裕 1, 牛山温子 3, 内山陽介 3, 大野浩之 3, 大橋公泰 2, 風間貴充 2, 木村亜莉沙 3, 小環 3, 座間俊輔 2, 高橋良幸 2, 竹澤有紗 3, 田中

葵 2, 照井善光 2, 永井慎一郎 2, 野村千枝 3, 花澤耕太郎 2, 早川雅人 2, 藤吉智治 2, 平林尚之 , 堀田沙希 3, 宮川弘之 3, 六鹿元雄 1, 村山悠子 3, 四柳道代 1, 渡辺一成 2, 佐藤恭子 11

国立医薬品食品衛生研究所，2 登録検査機関等，3 公的衛生研究所等

日本食品衛生学会

第 117 回学術講演会 , 2021 年 10 月 26 日～ 2021 年 11 月 2 日（Web 開催）

動物実験代替法
皮膚感作性試験代替法 Epidermal Sensitization Assay(EpiSensA) の Validation 研究
水町秀幸 1, 渡辺美香 , 生悦住茉友 , 梶原三智香 , 安田美智代 , 水野誠 2, 今井教安 2, 佐久間めぐみ 2, 芝田

桃子 2, 渡辺真一 3, 上野順子 3, Basketter D 4, Eskes C 5, Hoffmann S 6, Lehmann DM 7, 足利太可雄 8, 寒水孝司 9, 武吉正博 10, 鈴木1

将 1, 宮澤正明 1, 小島

肇8

花王株式会社 , 2 株式会社コーセー, 3 ライオン株式会社 , 4 DABMEB Consultancy Ltd., 5 SeCAM,Magliaso, 6 she consulting + services, 7 U.S. EPA, 8 JaCVAM, 国立医薬品食品衛生研究所 , 9 東京理科大学 , 10 一般財団法人化学物質評価研究機構
日本動物実験代替法学会

第 34 回大会 , 2021 年 11 月 11 日～2021 年 11 月 13 日
（Web 開催）

29