  ,+ (,**3)
  .  !

 " #$%& '()*+#,-./0 12345#6%7898:;<4=>? @ABCDEF:GH8IJ<KLM. N
OPQRSTU<V<.&%W0  XYABCDZRS[/\]^_`abcdZefgWhi#jk&
XYABCDlmnopqQF;rsZtu[/v
wW0

xq ?T$jyz{    |}  !"#  $%!&'()*+,-./01!23 45 !6789- +  ~i]\_: ;<!:=0/>!23?&'()*+!
@;AB CDE!FGHI J=,?KL MN!wxI I  3t B=C?{! . O!"# PQRS T!UV WX!&'

=C?KL-C()*+YB &'Z[\ ]^ _=0/>` - \]^T jkIuabcdefg JIpjs3t + Oq*23! ?Tiz{q(i*LL0/>!4!

 + ~i]\_ x+O T!UV *23 q4 ./01?hi1!jk`l!mn"#opI (i*L T!UV hi1q -* r js3t uIpI49  - *?(i*¡!¢£I ./01q 1* rv hi1!wxImn¤C? *¥!¢£q -* 0*  (i*¥!¢£q 1*yzv!23 {=C?KL-  +

3*!q,* r

 (i*23!wxI{jkB |} 3t?js3t

¢£¦p= !?,- 4 ¢ ~,?~!?B=jk`l!mn£I§¨© :ª¢£«¬¤C­ q ( ,  op  , T!UV `lI,phi1
 ?B=3t!wx

qjkq`L

 ./01 qpX`L,p  ~,B=3tq hi1./01

jkI

p,?`L !?,- ? ~,i*¡23!wxI{=C?KL-C .  ®¯ q js3t°±H¤C­  ²³´!3t>*+( `DE@µH¤C678 )¶¤C?=x·¸¹º , (i* 0/>2- !"#$%&'()*,ῌ ῌ  

῍  !" #$ῌ %& '()
$*+῍
, +2 -*, ,, ./01+23 / 4ῒ56789:;ΐ <ῌ =>ῌ ?ῌ :ῌ @

A.BCῌ DE?*F῏0GH/01++, + -./012#3$>9:0X;h-1+῍)GH<ῌ J

 ῐ<=Mῑ >-?MC῍ 'ῌ =>ῌ .?I=>JFCῌ @KLM.NOP*+῍ =>JopwSQ6b ῐJ

KLM.NFC<ῌ ῒQ6RSTUOV-*K+aῑ " ῐ  !ῑ =Q?UWXΐ ῐY !"#$%D&:E ῎ , +2  ῒ56

FC῍ QFAW

789:;ΐ ῐ'Z[\[ῑῌ Y ῑῌ ῒ().B#

.Xῌ + .:E-*Q6RSTU]^_`abc*d+e.fC῍U-*8b0Oῌ

B 2*῔C+ῌ B / y8FCa¡bfOghῌΐ ῐ,ij"-klD&:E ῎ ,

¢+῍ =>D£0J¤E z¥F,*  ῒ56789:;ΐῌ .mnῑῌ ῒopQ6¦?hῌ §GH(I:0"]^_w

RST%q`abcΐ ῐrstu/:

0ῐbyῑ 8J¨F.0῍ JD&:E ῎ , ,+  ῒ56789:;ΐῌ 1vῑῌ%©ῒw^xy2z3{|4}~5byqCbyM­+¯°±ῌ ¡.²³CN

6ΐ ῐvj"vD&:E ῎ , ,+  ῒ567

F'῍

89:;ΐῌ 1vῑ 0+C$῍ )GH'ῌ JKLM7FCBXῌ DE?

J ῐbyI]^_wῑ (8 =ª«K?¬L­®.

¢´ῌ byµ¶]^_w ῐO·ῌ U0ῑ/P<¸¹¤M+C῍ +<ῌ by ῐb b-+,.-bQº»¼Q»F½*'      !
"#$% &'  !()*% +,"#)&' -./ (2 389

4 567& % 8 ' :

"#  "#8 4A$BC%)

=D2 0%   + 1  Makoto Tominaga *++32. ,I-.FJF/JFK0LM 12N3(O +33, ,P4.F.FQJFN
RK56S738TU 9VWXYZ[.F\]X]^._56NRH :;.F`< =>.FJF/a?(O,**. ,KFb>cd@efgh\g8 NRki].]/  Cjl AB TRP mno C pDqE
TRP mnob> rF
Takeshi Nakano*++33. ,P4.F.FQGFNRK56M
sS738G5 H,IJFKLrBCMNRH +33/ ,EFNRNtOKF
C M N R H +330 , H N R N N R H,**1 , P EFNRNtuNRNQEF FNRvZwxW y  Cjz ,*** ,9V Salk Insti8
tute 56NRH  ,**, , NRk l{|.k}g~AB Q ]R(S"; tO {TE  ? U {fghl.VNR   8
WF XY; Z; [\Hiroyasu Nakano*+ +32. ,]^.FJF/0LM 12N
3_KJ(O ]^.F.FQ
JFNRK56S738 +33/ ,`ab.FJF/cFde ,**+ ,H`<,**1 ,Hfa? Cj8 z,*** ,**- ,g*h!NRijL &  | PRESTO N R H  k N R
k l AB NF-kB "+lmno
NR +lm p &' ROS  (; 5

< =>!(?@&' EF   ()GHB

qr+lst "2 uv(wx rFk l rF=.FQ WF y z,{ Hidemitsu Nakamura*+ +33- ,|P.FGF/GEFK0L +332 ,H.F.FQGFTKFN
RK56S738 H,HNRKCMNR
H ,**, , P GL }NRNCM
NRH ,**2 ,|P.F.FQGFT8 N
KFNRKCkNRH Cj
Rk l AB Q ]4vb>~ Q o
WF #  Kensuke Nabeta
No. 2, p. /1, 

Vol. .1,

  Hiromi Nishida*++33* ,|P.FGF/GEFK0L+33/ ,H.F.FQGFTKFNRKUTF 56S738 H,IJ
FKLrBCMNRH +330 ,EFN
RNtOKFCMNRH +331 ,|P.
F  y + l  F N R N d e ,**- ,PEFNRNKFeNR]/ NRH ,**/ ,|P.F.FQGF
8
TKFNRKCkfa? Cj
NRk l AB
 g]XYl  WF
k. IJ}{ KF  Yoshiyuki Nishimiya*+ +330 ,|.FF/ EFF
K0L ,**+ ,H.F.FQFNRK F 56S7Ms - ,385

H,PL KeNRN Cj
8 NRk l AB /]¡bC¢Z£~ .
> /]¡(¤¥b /]WF¡LU  8¦§¨]© ª  Masayuki Muramatsu
*+ ,**, ,«¬.FF/y FK
0L ,**. ,H.F.FQFNRKy F 56sS738 ,**.
,IJFKLrBCMNRH (DC+) ,**1,|P.F.FQ­hKFNRKTKF 56MsS738 H,
PGL }NRNCMNRH Cj
8 NRk l AB ^uE b> ®^©¯b> W
F  ¦§¨]© °± 5 ²¥³;*+ +330 ,   Ai MiuraL L KNRQ¡L K
NRN¢£´¤H ,*** ,HNRNCM
K¥d¤H ,**+ , P L Ke8 NRkNRNµ¦¤H Cjl AB /]¡§¶ NMR .·x¨ /]¡¸ ©ª
U WF NMR "« ¹[ ¬1 ! Masaru Yamanaka *+,**/ ,º­.F F/0L ,*+*,H.F.FQ »KFNRK56S7
Ms38 NRk l AB ¼/]¡>!½ ^x} c e WF ®