The 45th Annual Japan-U.S. Joint Conference on Parasitic Diseases

Japan-U.S. Parasitic Diseases Panel Meeting

Japan-U.S. Cooperative Medical Science Program

National Institute of Infectious Diseases
Tokyo, Japan
January 10-11, 2011

Agenda - The 45th Annual Japan-U.S. Joint Conference
on Parasitic Diseases
National Institute of Infectious Diseases, Tokyo, Japan
January 10-11, 2011

Monday, January 10th
10:00

WelcomeTomoyoshi Nozaki, Organizer of the 45th Japan-U.S. Joint Conference
Opening remarks
Kenji Hirayama, Japanese Panel ChairJames Kazura, U.S. Panel Chair

10:10

The Japan-U.S. Panel on Parasitic Diseases
Malla R. Rao, National Institutes of Health, U.S.A. and Kenji Hirayama,Nagasaki University[Schistosoma and Helminth-1] Chairs: Dan Colley and Kenji Hirayama
10:25

SCORE – Comparative studies on how to control and eliminate
Schistosoma mansoni and S. haematobium
Daniel G. Colley, University of Georgia, U.S.A.

10:43

Expression and kinetics feature of thioredoxin glutathione
reductase of Schistosoma japonicum
Chuanxin Yu, Jiangsu Institute of Parasitic Diseases, China

11:01

Studies on the potential drug target Sj ANT and discovery of thecompounds against Schistosoma japonicum in vitro
Hu Wei, Chinese Center for Disease Control and Prevention, China

11:19

Immunogenetic analysis of the patients with early onset
schistosomal fibrosis in Sorsogon Province, the Philippines
Kenji Hirayama, Nagasaki University, Japan

11:32

Surveys on newly found schistosomiasis endemic foci inSoutheast Asian countries
Hiroshi Ohmae, National Institute of Infectious Diseases, Japan

11:45

Regulation of hepatic granuloma formation by IL-4/IL-13 in S.
japonicum infected mice
Takenori Seki, Tokyo Medical and Dental University, Japan

11:58Current situation of Angiostrongylus cantonensis andangiostrongyliasis in Japan: from geographic distribution togenotype diversity
Toshihiro Tokiwa, Tokyo Medical and Dental University, Japan

12:11

Genome and transcriptome sequencing of Strongyloides
venezuelensis, an animal parasitic nematode
Eiji Nagayasu, University of Miyazaki, Japan

12:24

Pathogenesis of liver fluke-induced cholangiocarcinoma: anupdate
Banchob Sripa, Khon Kaen University, Thailand

12:42

LUNCH

[Malaria-1] Chairs: James W. Kazura and Taka Tsuboi
14:00

Plasmodium vivax subtelomeric transmembrane protein (PvSTP)
localized at the Schüffner's dots of parasite-infected erythrocytes
Osamu Kaneko, Nagasaki University, Japan14:13

New anti-malaria strategies: Cell death and fluorescent drugs
Kevin SW Tan, National University of Singapore, Singapore

14:31

Secretion and discharge of an alien protein in the saliva
produced in a transgenic mosquito, Anopheles stephensi
Hiroyuki Matsuoka, Jichi Medical University, Japan

14:44

Post-genome novel blood-stage malaria vaccine candidate
discovery by wheat germ cell-free system
Takafumi Tsuboi, Ehime University, Japan

14:57

Plasmodial ortholog of Toxoplasma gondii rhoptry neck protein 3
is localized to the rhoptry body
Daisuke Ito, Ehime University, Japan15:10

Prevention of cerebral malaria by Flt3 ligand during infection withPlasmodium berghei ANKA
Katsuyuki Yui, Nagasaki University, Japan

15:23

Progress toward the development of Plasmodium falciparum andPlasmodium vivax transmission blocking vaccines (TBV)
Nirbhay Kumar, Tulane University, U.S.A.

15:41

New antimalarial drug development research- current status ofendoperoxide
Hye-Sook Kim, Okayama University, Japan

15:54

Population structure and transmission dynamics of Plasmodium
vivax in the Republic of Korea based on microsatellite DNA
Moritoshi Iwagami, National Center for Global Health and Medicine,
Japan

16:07

In vitro sensitivity of Plasmodium falciparum clinical isolates
from the China-Myanmar border area to anti-malarial drugs andpolymorphisms in associated genes
Zhaoqing Yang, Kunming Medical University, China

16:25

Genetic variations in Indian populations and its implications ingenetic and infectious diseases
Kumarasamy Thangaraj, Centre for Cellular and Molecular Biology,
India

16:43

BREAK

[Leishmania and Trypanosoma] Chair: Kiyoshi Kita
17:00

Involvement of CD4+Foxp3+ regulatory T cells in the persistentinfection of Leishmania donovani in the liver of
immunodeficiency aly/aly mice
Saruda Tiwananthagorn, Hokkaido University, Japan

17:13

Community-based intervention study using neem extract tocontrol visceral leishmaniasis in Bangladesh
Farhana Ferdousi, University of Tsukuba, Japan

17:26

Efficacy of permethrin treated long-lasting insecticidal nets
against phlebotomine sand flies
Chizu Sanjoba, The University of Tokyo, Japan

17:39

Characterization of Iron-sulfur clusters (ISC) machinery of L.
donovani to understand the physiological role of Fe-S proteins indrug resistance
Vahab Ali, RMRIMS, India

17:57

A phylogeny of Leishmania major s.l. inferred from nagt
sequencesSambuu Gantuya, The University of Tokyo, Japan18:10

Commonness and uniqueness of tandem repeat antigens in thetrypanosomatid parasites
Yasuyuki Goto, The University of Tokyo, Japan

18:23

Structural analysis of glycerol kinase from African humantrypanosomes
Emmanuel Oluwadare Balogun, The University of Tokyo, Japan

18:36

The crystal structure of the trypanosomal cyanide-insensitive
alternative oxidase (TAO): a novel drug target for the African
trypanosomiasis
Tomoo Shiba, The University of Tokyo, Japan

18:49

Structure-based design of selective and potent 5-substituted
orotate derivatives inhibitors against Trypanosoma cruzi
dihydroorotate dehydrogenase
Daniel Ken Inaoka, The University of Tokyo, Japan

19:02

Adjournment

19:10

Meeting reception—Cafeteria (located on the 1st floor of the building)Tuesday, January 11th
[Amoeba and other protozoa] Chairs: William A. Petri and Tomo Nozaki
09:00

Regenerating gene (REG) 1 as a marker and mediator of intestinal
injury and repair
Kristine M. Peterson, University of Virginia, U.S.A.

09:18

Gene silencing of mitosomal proteins cause growth inhibition
suggests essentiality of mitosomes in Entamoeba histolytica
Fumika Mi-ichi, National Institute of Infectious Diseases, Japan

09:31

A study on the pathogenicity of Entamoeba moshkovskii
Shinjiro Hamano, Nagasaki University, Japan

09:44

Structural and functional investigations on the attachment andphagocytosis of host cells by Entamoeba histolytica
Sunando Datta, Indian Institute of Science Education and Research,India

10:02

Emerging trends in the aetiology of enteric parasites with specialreference to change in Entamoeba histolytica infestation inKolkata, India
Sandipan Ganguly, National Institute of Cholera & Enteric Diseases,
India

10:20

Mechanism of trifluoromethionine resistance in Entamoeba
histolytica
Gil M. Penuliar, National Institute of Infectious Diseases, Japan

10:33

Amebiasis, tropical enteropathy, and genetic susceptibility tomalnutrition: A journey with a surprising waypoint
William A. Petri Jr., University of Virginia, U.S.A.

10:51

BREAK

11:05

Metabolomic analysis during differentiation of enteric protozoan
parasite Entamoeba into the infectious cyst stage
Ghulam Jeelani, National Institute of Infectious Diseases, Japan

11:18

Comparison of gene profiles between trophozoite and cyst ofAcanthamoeba with microarray and KOG analysis
Eun-Kyung Moon, Kyungpook National University, Korea

11:36

Effects of glucose restriction on the cell cycle of Trichomonas
vaginalis
Petrus Tang, Chang Gung University, Taiwan

11:54

Molecular characterization of Trichomonas vaginalis isolates inthe Philippines
Windell L. Rivera, University of the Philippines, Philippines

12:12

Functional identification of end-binding 1 (EB1) protein of Giardia
lamblia by complementation and interactome analyses
Soon-Jung Park, Yonsei University College of Medicine, Korea

12:30

LUNCH

[Apicomplexan parasites] Chair: Shigeyuki Kano
13:50

Spherical body protein 4 is a new serological antigen for theglobal detection of Babesia bovis infection in cattle
Ikuo Igarashi, Obihiro University of Agriculture and Veterinary
Medicine, Japan

14:03

Characterization of Toxoplasma gondii transcriptome with amassive parallel sequencing method
Junya Yamagishi, Obihiro University of Agriculture and Veterinary
Medicine, Japan

14:16

The effect of host GPI-anchor to Toxoplasma gondii infection
Michiru Tahara, National Institute of Infectious Diseases, Japan

14:29

Plant hormone cytokinins: Elucidating their role in Toxoplasma
gondiiSyed Bilal Ahmad Andrabi, National Institute of Infectious Diseases,Japan

14:42

Toxoplasmosis in mainland China
Xiao-Guang Chen, Southern Medical University, China[Malaria-2] Chair: Malla R. Rao
15:00

The Southwest Pacific NIH International Center of Excellence forMalaria ResearchJames W. Kazura, Case Western Reserve University, U.S.A.

15:18

The International Centers for Excellence in Malaria Research
Malla R. Rao, National Institutes of Health, U.S.A.

15:36

BREAK

15:50

Plasmodium vivax: Significance and research priorities
highlighted by iVax community
Jetsumon Sattabongkot Prachumsri, AFRIMS, Thailand

16:08

China-Thailand-Myanmar ICEMR Program
Guiyun Yan, University of California at Irvine, U.S.A.

[Helminth-2] Chair: Daniel G. Colley
16:26

Cestode zoonoses in Asia: towards evidence based control
Akira Ito, Asahikawa Medical University, Japan

16:39An immunochromatographic test for diagnosis of alveolar
echinococcosis
Yasuhito Sako, Asahikawa Medical University, Japan

16:52

Usefulness of serological and molecular tools for detection ofneurologic parasitic zoonoses in rural areas of southwest
Cameroon: toxocariasis, cysticercosis and paragonimiasis
Agathe Nkouawa, Asahikawa Medical University, Japan

17:05

Phosphagen kinases of trematodes: possible chemotherapeutictargets
Takeshi Agatsuma, Kochi University, Japan

17:18

Evaluation of urine-based IgG4 ELISA for detecting lymphatic
filarial infection and the development of a visual diagnostic
method with urine samples
Eisaku Kimura, Aichi Medical University, Japan

17:31

Basophils are essential for rapidly expelling Strongyloides
venezuelensis
Makoto Matsumoto, Hyogo College of Medicine, Japan

17:44

Conclusion of Japan-U.S. Joint Conference on Parasitic Diseases

Intestinal and Free-Living Protozoan Parasites Meeting

National Institute of Infectious Diseases
Tokyo, Japan
January 12, 2011

Agenda- Intestinal and Free-Living Protozoan Parasites Meeting
National Institute of Infectious Diseases, Tokyo, Japan
January 12, 2011

Wednesday, January 12th
10:00

Opening remarks
Tomoyoshi Nozaki

1. Iron-sulfur clusters assembly of Entamoeba histolytica: Purification andcharacterization cytosolic Fe-S clusters assembly components
Vahab Ali, RMRIMS, India
2. Molecular insights into the amoebic retromer complex
Sunando Datta, Indian Institute of Science Education and Research, India
3. Entamoeba invadens: Transcriptome analysis during encystation
Aleyla Escueta- De Cadiz, National Institute of Infectious Diseases, Japan
4. Trafficking mechanism of phagosomal enzymes in Entamoeba
histolytica
Atsushi Furukawa, National Institute of Infectious Diseases, Japan
5. Emerging trends in the aetiology of enteric parasites with specialreference to change in Entamoeba histolytica infestation in Kolkata, India
Sandipan Ganguly, National Institute of Cholera & Enteric Diseases, India
6. A study on the pathogenicity of Entamoeba moshkovskii
Shinjiro Hamano, Nagasaki University, Japan
7. Metabolomic analysis of sulfur containing amino acid metabolism in E.
histolytica
Afzal Husain, National Institute of Infectious Diseases, Japan
8. Development of nucleic acid amplification assays for highly sensitive
detection of Cryptosporidium in water samples
Shinji Izumiyama, National Institute of Infectious Diseases, Japan
9. Analysis of the protein import machinery in the Entamoeba
mitochondrial remnant
Takashi Makiuchi, National Institute of Infectious Diseases, Japan
10. Gene silencing of mitosomal proteins cause growth inhibition
suggests essentiality of mitosomes in Entamoeba histolytica
Fumika Mi-ichi, National Institute of Infectious Diseases, Japan
11. Autophagy related proteins in encystation of Acanthamoeba
Eun-Kyung Moon, Kyungpook National University, Korea12. Functional identification of end-binding 1 (EB1) protein of Giardia
lamblia by complementation and interactome analyses
Soon-Jung Park, Yonsei University College of Medicine, Korea
13. Regenerating gene (REG) 1 as a marker and mediator of intestinal
injury and repair
Kristine M. Peterson, University of Virginia, U.S.A.
14. 1) Role of acid vesicles in host cell killing by E. histolytica
2) A genome wide lentivirus shRNA library screen for host genes
controlling susceptibility to E. histolytica killing3) Genotyping of clinical isolates of E. histolytica
4) Role of the leptin receptor in innate resistance to amebiasis
5) Transmembrane kinases and regulation of E. histolytica
phagocytosis
6) A negative selectable marker for E. histolytica and attempts tointegrate foreign DNA in E. histolytica
7) A virulence gene program induced by URE3-BP
William A. Petri, University of Virginia, U.S.A.
15. Detection and subtype identification of Blastocystis isolates fromwastewater samples in the Philippines
Windell L. Rivera, University of the Philippines, Philippines
16. Diversity of vesicular trafficking in phagocytic protozoa andsignificance of traffic in Entamoeba histolytica
Yumiko Saito-Nakano, National Institute of Infectious Diseases, Japan
17. Subtype–associated variations in Blastocystis pathobiology
Kevin SW Tan, National University of Singapore, Singapore
18. Functional genomics of Acanthamoeba castellani Neff
Petrus Tang, Chang Gung University, Taiwan
19. Comprehensive identification of protozoan parasites: distribution ofspecies and genotypes in Sumba Island, Indonesia
Masaharu Tokoro, Kanazawa University, Japan
20. 18S rDNA sequence typing on the clinical isolates of Acanthamoeba inJapanKenji Yagita, National Institute of Infectious Diseases, Japan