Table 3-1. Proposal for drug coding of “List of drugs to be prescribed with special caution” 1)
Therapeutic category/JAN English nameJapan 2)

ATC3)

Aripiprazole Hydrate

1179045

N05AX12Asenapine Maleate

1179056

N05AH05

Blonanserin

1179048

N05AX

Bromperidol

1179028

N05AD06

Chlorpromazine Hydrochloride

1171001

N05AA01

Chlorpromazine Phenolphthalinate

1171005

N05AA01

Clocapramine Hydrochloride Hydrate

1179030

N05AX

Clozapine

1179049

N05AH02

Fluphenazine Maleate

1172009

N05AB02

Haloperidol

1179020

N05AD01

Levomepromazine Maleate

1172014

N05AA02

Mosapramine Hydrochloride1179035

N05AX10

Nemonapride

1179036

N05AL

Olanzapine

1179044

N05AH03

Oxypertine

1179011

N05AE01

Paliperidone

1179053

N05AX13Perphenazine

1172006

Nervous system: Overall antipsychotic drugs - Antipsychotic drugs

N05AB03117200723

Therapeutic category/JAN English nameJapan 2)ATC3)

Perphenazine Fendizoate

1172004

N05AB03

Perphenazine Maleate

1172013

N05AB03

Perospirone Hydrochloride Hydrate

1179043

N05AX

Pimozide

1179022

N05AG02

Pipamperone Hydrochloride

1179006

N05AD05

Prochlorperazine Maleate

1172010

N05AB04

Propericiazine (Periciazine)

1172005

N05AC01Quetiapine Fumarate

1179042

N05AH04

Risperidone

1179038

N05AX08

Spiperone

1179015

N05AD

Sulpiride1179016
N05AL01
2329009

Sultopride Hydrochloride

1179032

N05AL02

Tiapride Hydrochloride

1190004

N05AL03

Timiperone

1179026

N05AD

Zotepine

1179024

N05AX11

Alprazolam

1124023

N05BA12

Bromazepam

1124020

N05BA08

Combination (see Table3-3)
Nervous system: Benzodiazepines

24

Therapeutic category/JAN English name

Japan 2)

ATC3)

Brotizolam

1124009

N05CD09

Chlordiazepoxide

1124028

N05BA02

Clorazepate Dipotassium

1124015

N05BA05

Clotiazepam

1179012

N05BA21

Cloxazolam1124014

N05BA22

Diazepam

1124017

N05BA01

Estazolam

1124001

N05CD04

Ethyl Loflazepate

1124029

N05BA18

Etizolam

1179025

N05BA19

Fludiazepam

1124019

N05BA17

Flunitrazepam

1124008

N05CD03

Flurazepam Hydrochloride

1124002

N05CD01

Flutazolam

1124024

N05BA

Flutoprazepam

1124027

N05BA

Haloxazolam

1124005

N05CD

Lorazepam

1124022

N05BA06

Lormetazepam

1124010

N05CD06

Medazepam

1124021

N05BA03

Mexazolam

1124025

N05BA

Nimetazepam

1124004

N05BA

25

Therapeutic category/JAN English nameJapan 2)

ATC3)

Nitrazepam

1124003

N05CD02

Oxazolam

1124013

N05BAQuazepam

1124030

N05CD10

Rilmazafone Hydrochloride Hydrate

1129006

N05CD

Tofisopam

1124026

N05BA23

Triazolam

1124007

N05CD05

Eszopiclone

1129010

N05CF04

Zolpidem Tartrate

1129009

N05CF02

Zopiclone

1129007

N05CF01

Amitriptyline Hydrochloride

1179002

N06AA09

Amoxapine

1179001

N06AA17

Clomipramine Hydrochloride

1174002

N06AA04

Dosulepin Hydrochloride

1179027

N06AA16

Imipramine Hydrochloride

1174006

N06AA02

Lofepramine Hydrochloride

1174004

N06AA07

Nortriptyline Hydrochloride

1179004

N06AA10

Trimipramine Maleate

1174005

N06AA06

Nervous system: Non-benzodiazepinesNervous system: Tricyclic antidepressantsNervous system: Selective serotonin reuptake inhibitor (SSRI)

26

Therapeutic category/JAN English nameJapan 2)

ATC3)

Escitalopram Oxalate

1179054

N06AB10

Fluvoxamine Maleate

1179039

N06AB08

Paroxetine Hydrochloride Hydrate

1179041

N06AB05

Sertraline Hydrochloride

1179046

N06AB06

Biperiden Hydrochloride

1162001

N04AA02

Mazaticol Hydrochloride Hydrate

1169004

N04AA10

Piroheptine Hydrochloride

1169003

N04AA

Profenamine Hibenzate

1163002

N04AA05

Profenamine Hydrochloride

1163001

N04AA05

Nervous system: Antiparkinsonian drugs – Anticholinergic drugs

Promethazine Hydrochloride

R06AD024413002
D04AA10

Promethazine Hibenzate

R06AD024413002
D04AA10

Promethazine Methylenedisalicylate

R06AD024413002
D04AA10Trihexyphenidyl Hydrochloride

1169001
N04AA01
1169002

Systemic hormonal preparations, excl. Sex hormones and insulins: Oralcorticosteroids27

Therapeutic category/JAN English nameJapan 2)

ATC3)

Betamethasone

2454004

H02AB01

Cortisone Acetate

2452001

H02AB10Dexamethasone

D07AB192454002
H02AB02

Hydrocortisone

2452002

H02AB09

Methylprednisolone

2456003

H02AB04

Prednisolone

2456001
H02AB06
2456002

Triamcinolone

2454003

Combination (see Table3-3)

H02AB08

Blood and blood forming organs: Antithrombotic drugs

Acetylsalicylic acid (Aspirin)

1143001

N02BA01

3399007

B01AC06

Apixaban

3339004

B01AF02

Cilostazol

3399002

B01AC23

Clopidogrel Sulfate

3399008

B01AC04

Dabigatran Etexilate Methanesulfonate

3339001

B01AE07

Edoxaban Tosilate Hydrate

3339002

B01AF03

Prasugrel Hydrochloride

3399009

B01AC2228

Therapeutic category/JAN English nameJapan 2)

ATC3)

Rivaroxaban

3339003

B01AF01

Ticlopidine Hydrochloride

3399001

B01AC05

Ticagrelor3399011

B01AC24

Warfarin potassium

3332001

B01AA03

Combination (see Table3-3)
Cardiovascular system: DigitalisDigoxin

2113003
C01AA05
2113004

Metildigoxin

2113005

C01AA08

Azosemide

2139008

C03CA

Bumetanide

2139004

C03CA02

Furosemide

2139005

C03CA01

Piretanide

2139007

C03CA03

Torasemide

2139009

C03CA04

Eplerenone

2149045

C03DA04

Spironolactone

2133001

C03DA01

2123002

C07AA01

Cardiovascular system: High-ceiling diuretics

Cardiovascular system: Potassium-sparing agents

Cardiovascular system: Beta blocking agents
Alprenolol Hydrochloride

29Therapeutic category/JAN English nameJapan 2)

ATC3)

Arotinolol Hydrochloride

2123014

C07AA

Bufetolol Hydrochloride

2123006

C07AA

Carteolol Hydrochloride

2123005

C07AA152149025

S01ED052123015

C07AA12

Nadolol
Nipradilol

C07AA
2149021
S01ED

Pindolol

2123009
C07AA032149011

Propranolol Hydrochloride

2123008
C07AA05
2149014

Cardiovascular system: Alpha1 blocking agents
Bunazosin Hydrochloride

2149015

C02CA

Doxazosin Mesilate

2149026

C02CA04

Prazosin Hydrochloride

2149002

C02CA01

Terazosin Hydrochloride Hydrate

2149023

G04CA03

Urapidil2149020

C02CA06

Alimemazine Tartrate

4413003

R06AD01Chlorpheniramine Maleate

4419001

R06AB04

Respiratory system: H1 receptor antagonists (1st generation)

30

Therapeutic category/JAN English nameJapan 2)

ATC3)4419003
Clemastine Fumarate

4419008

R06AA04

Cyproheptadine Hydrochloride Hydrate

4419005

R06AX02

D-chlorpheniramine Maleate

4419002

R06AB04

Diphenhidramine

4411001

R06AA02

Homochlorcyclizine Hydrochloride

4419006

R06AE

Hydroxyzine Hydrochloride

1179005

N05BB01

Hydroxyzine Pamoate

1179019

N05BB01

Promethazine Hibenzate relisted)

4413002

R06AD02

Promethazine Hydrochloride (relisted)

4413002

R06AD02Promethazine Methylenedisalicylate (relisted)

4413002

R06AD02

Cimetidine

2325001

A02BA01

Famotidine

2325003

A02BA03

Lafutidine

2325006

A02BA08

Nizatidine

2325005

A02BA04

Ranitidine Hydrochloride

2325002

A02BA02

Roxatidine Acetate Hydrochloride

2325004

A02BA06

Combination (see Table3-3)
Alimentary tract and metabolism: H2 receptor antagonists

Alimentary tract and metabolism: Antiemetic agents31

Therapeutic category/JAN English nameJapan 2)

ATC3)

Metoclopramide

2399004

A03FA01

Promethazine Hibenzate (relisted)

R06AD024413002
D04AA10

Promethazine Hydrochloride (relisted)

R06AD024413002
D04AA10

Promethazine Methylenedisalicylate (relisted)

R06AD024413002
D04AA10

Alimentary tract and metabolism: Drugs for constipation
Magnesium Oxide

2344002

A02AA022344009

A06AD02

Buformin Hydrochloride

3962001

A10BA03

Metformin Hydrochloride

3962002

A10BA02

Acetohexamide

3961001

A10BB31Chlorpropamide

3961004

A10BB02

Glibenclamide

3961003

A10BB01

Gliclazide

3961007

A10BB09

Glimepiride

3961008

A10BB12

Alimentary tract and metabolism: Biguanides

Combination (see Table3-3)
Alimentary tract and metabolism: sulfonylureas

32Therapeutic category/JAN English nameJapan 2)

ATC3)

Glyclopyramide

3961002

A10BB

Tolbutamide

3961006

A10BB03

Acarbose

3969003

A10BF01

Miglitol

3969009

A10BF02

Voglibose

3969004

A10BF033969007

A10BG03

Canagliflozin Hydrate

3969022

A10BK02

Dapagliflozin Propylene Glycolate Hydrate

3969019

A10BK01

Empagliflozin

3969023

A10BK03

Ipragliflozin L-proline

3969018

A10BK

Luseogliflozin Hydrate

3969020

A10BK

Tofogliflozin Hydrate

3969021

A10BK

Combination (see Table3-3)
Alimentary tract and metabolism: Alpha glucosidase inhibitors

Combination (see Table3-3)
Alimentary tract and metabolism: Thiazoridinediones
Pioglitazone Hydrochloride
Combination (see Table3-3)
Alimentary tract and metabolism: Sodium-glucose co-transporter 2 (SGLT2)
inhibitors

Urologicals: Muscarinic receptor antagonists

33

Therapeutic category/JAN English name

Japan 2)

ATC3)

Fesoterodine Fumarate

2590015

G04BD11

Imidafenacin

2590013

G04BD

Oxybutynin Hydrochloride

2590005

G04BD04

Propiverine Hydrochloride

2590007

G04BD06

Solifenacin Succinate

2590011

G04BD08

Tolterodine Tartrate

2590012G04BD07Acemetacin

1145003

M01AB11

Amfenac Sodium Hydrate

1147006

M01AB

Ampiroxicam

1149030

M01AC

Acetylsalicylic acid (Aspirin) (relisted)

1143001

N92BA01

3399007

B01AC06

1149009

M01AX

Musculo-skeletal system: Non-steroidal antiinflammatory drugs (NSAIDs)

Bucolome
Diclofenac Sodium

M01AB05
1147002

S01BC03
M02AA15

Emorfazone

1148004

N02BG

Etodolac

1149032

M01AB08

Flufenamate Aluminum

1141004

M01AG03

Flurbiprofen

1149011

M01AE0934

Therapeutic category/JAN English nameJapan 2)

ATC3)
M02AA19

Ibuprofen

1149001

Indometacin

M01AE01
C01EB031145001
M01AB01
1145002
M02AA23
Indomethacin Farnesil

1145005

M01AB01

Lornoxicam

1149036

M01AC05

Loxoprofen Sodium Hydrate

M01AE
1149019
M02AA

Mefenamic Acid

1141005

M01AG01

Meloxicam

1149035

M01AC06

Mofezolac

1149033

M01AX

Nabumetone

1149027

M01AX01

Naproxen

1149007

M01AE02

Oxaprozin

1149026

M01AE12

Piroxicam

M01AC01
1149017

M02AA07
S01BC06

Pranoprofen

1149010S01BC09

Proglumetacin Maleate

1145004

M01AB1435

Therapeutic category/JAN English nameJapan 2)

ATC3)

Sulindac

1149015

M01AB02

Tiaprofenic Acid

1149025

M01AE11

Tiaramide Hydrochloride

1148001

N02BG

Zaltoprofen

1149029

M01AE

Combination (See Table 3-3)
Japanese version available at http://www.jpn-geriat-soc.or.jp/tool/xls/list_03.xlsx or http://www.jpngeriat-soc.or.jp/tool/pdf/list_02.pdf.
ATC: Anatomical Therapeutic Chemical Classification System
JAN: Japanese Accepted Names for Pharmaceuticals
Japan: the first 7-digit numbers of the code of the Japanese drug price list.
1)

Drugs that had been previously approved but do not currently being marketed are excluded.

The list includes long-term oral use drugs as a general rule, except self-injection insulin, according tothe guidelines (Japan Geriatric Society. Guidelines for Medical Treatment and its Safety in the elderly2015 (In Japanese). Toyko, Medical View Co., Ltd. 2015.)
2)

A different base adduct may or may not require different codes in Japan; hydroxyzine(1179005 for hydrochloride, 1179019 for pamoate) or promethazines (4413002).
3)

ATC codes for topical use were excluded, e.g. A07EA Corticosteroids acting locally, D04AA

Antihistamines for topical use; defined daily dose (DDD) are not available for most of those.
4)

The guidelines distinguish sulpiride and sultopride from other antipsychotic drugs.

5)

The guidelines distinguish acetyhlsalicylic acid (aspirine) from other antithrombotic drugs.

6)

The guidelines distinguish oxybutynin from other muscarinic receptor antagonists.
36

7)

The guidelines does not have metildigoxin (oral), however it is marketed and added to theTable 3-1 from molecular based perspectives.
8)

The guidelines should be weighed against all of the listed substance. For example, theguidelines alert all insulin products but limited to sliding scale administration only, metildigoxin is notlisted..

37

Table 3-2. Proposal for drug coding of “List of drugs to consider starting” 1)
Therapeutic category/JAN English nameJapan 2)

ATC 2)

Antiparkinson drugs
Combination (see Table 3-3)
Vaccine: Influenza
Influenza HA Vaccine (A/B)

NA

J07BB02

Adsorbed Influenza Virus Vaccine (H5N1)

NA

J07BB02

Pneumococcal Polysaccharide Conjugate Vaccineadsorbed

631140G

J07AL52

Pneumococcus Vaccine

6311400

J07AL01

Alacepril

2144003

C09AA

Benazepril Hydrochloride

2144007

C09AA07

Captopril

2144001

C09AA01

Cilazapril Hydrate

2144005

C09AA08

Delapril Hydrochloride

2144004

C09AA12

Enalapril Maleate

2144002

C09AA02

Imidapril Hydrochloride

2144008

C09AA16

Lisinopril Hydrate

2144006

C09AA03

Perindopril Erbumine

2144012

C09AA04

Vaccine: Pneumococcal

Cardiovascular system: Angiotensin conversion enzyme (ACE) inhibitor

38

Therapeutic category/JAN English name

Japan 2)ATC 2)

Quinapril Hydrochloride

2144010

C09AA06

Temocapril Hydrochloride

2144009

C09AA14

Trandolapril

2144011

C09AA10Azilsartan

2149048

C09CA09

Candesartan Cilexetil

2149040

C09CA06

Irbesartan2149046

C09CA04

Olmesartan Medoxomil

2149044

C09CA08

Telmisartan

2149042

C09CA07

Valsartan

2149041

C09CA03

Losartan Potassium2149039

C09CA01

Atorvastatin Calcium Hydrate

2189015

C10AA05

Fluvastatin Sodium

2189012C10AA04

Pitavastatin Calcium Hydrate

2189016

C10AA08

Pravastatin Sodium

2189010

C10AA03

Rosuvastatin Calcium

2189017

C10AA07

Simvastatin

2189011

C10AA01

Cardiovascular system: Angiotensin receptor blocker (ARB)

Coombination (See Table 3-3)
Cardiovascular system: Lipid modifying agents (Statine)

Coombination (See Table 3-3)39

Therapeutic category/JAN English name

Japan 2)ATC 2)

Naftopidil

2590009

G04CA

Silodosin

2590010

G04CA04

Tamsulosin Hydrochloride

2590008

G04CA02

Actarit

1149031

M01CX

Auranofin

4420001

M01CB03

Bucillamine

4420002

M01CC02

Iguratimod

3999031

M01CX

Leflunomide

3999020

L04AA13

Lobenzarit Sodium

1149020

M01CX

Methotrexate

4222001

L01BA01

3999016

L04AX03

Mizoribine

3999002

L04AX

Salazosulfapyridine

6219001

A07EC01

Tofacitinib Citrate

3999034

L04AA29

Urologicals: Drugs for benign prostatic hypertrophy (selective alpha-1blockers)

Antineoplastic and immunomodulating agents: Drugs for rheumatoidarthritis

ATC: Anatomical Therapeutic Chemical Classification SystemJAN: Japanese Accepted Names for Pharmaceuticals
1) Drugs that had been previously approved but do not currently being marketed are excluded. The list40

includes long-term oral use drugs as a general rule, except self-injection insulin, according to theguidelines (Japan Geriatric Society. Guidelines for Medical Treatment and its Safety in the elderly2015 (In Japanese). Toyko, Medical View Co., Ltd. 2015.)
2) the first 7-digit numbers of the code of the Japanese drug price list.A different base adduct may or
may not require different codes in Japan; hydroxyzine (1179005 for hydrochloride, 1179019 forpamoate) or promethazines (4413002).
3) ATC codes for topical use were excluded, e.g. A07EA Corticosteroids acting locally, D04AA
Antihistamines for topical use; defined daily dose (DDD) are not available for most of those.

41

Table3-3 Proposal for coding the combination drugs of “List of drugs to be prescribed with special caution” and “List of drugs to consider starting”

42

Combination drugsJapan 1)

ATC2)(substance name in JAN)
“List of drugs to be prescribed with special caution”
Chlorpromazine Hydrochloride

R06AD52 promethazine, combinations
1179100

Phenobarbital *or
1179101

Promethazine Hydrochloride

N05AA01 chlorpromazine and R06AD02 promethazine

Acetylsalicylic acid (aspirin)
1143010
Aluminum Glycinate *N02BA51 acetylsalicylic acid, combinations excl. psycholeptics
3399100

Magnesium Carbonate *N02BA51 acetylsalicylic acid, combinations excl. psycholeptics
Acetylsalicylic acid (aspirin)
3399101

orClopidogrel Sulfate
B01AC06 acetylsalicylic acid and B01AC04 clopidogrel
Acetylsalicylic acid (aspirin)
3399102

B01AC56 acetylsalicylic acid, combinations with proton pump inhibitors

Lansoprazole *43Metformin Hydrochloride
3969100

A10BD05 metformin and pioglitazone

3969101

A10BD06 glimepiride and pioglitazone

Pioglitazone Hydrochloride
Glimepiride
Pioglitazone Hydrochloride
A10BD Combinations of oral blood glucose lowering drugs
Mitiglinide
3969102

orVoglibose
A10BX08 mitiglinide and A10BF03 voglibose
Pioglitazone
3969103

A10BD09 pioglitazone and alogliptin

3969104

A10BD08 metformin and vildagliptin

3969105

A10BD13 metformin and alogliptin

Alogliptin*
Metformin
Vildagliptin*
Alogliptin*
Metformin“List of drugs to consider starting”
44Entacapone *Carbidopa Hydrate

1169102

N04BA03 levodopa, decarboxylase inhibitor and COMT inhibitor

1169101

N04BA02 levodopa and decarboxylase inhibitor

1169100

N04BA02 levodopa and decarboxylase inhibitor

2149121

C09CA09 azilsartan medoxomil and C08CA01 amlodipine

Levodopa
Carbidopa Hydrate *Levodopa
Benserazide Hydrochloride *Levodopa
Azilsartan
Amlodipine Besilate
Azelnidipine

C08C selective calcium channel blockers with mainly vascular effects
2149115

Olmesartan Medoxomil

and C09CA08 olmesartan medoxomil

Amlodipine Besilate
2149118

C09DB05 irbesartan and amlodipine

Irbesartan

45

Amlodipine Besilate
2149116

C09DB07 candesartan and amlodipine

2149117

C09DB04 telmisartan and amlodipine

2149114

C09DB01 valsartan and amlodipine

2149119

C09DA04 irbesartan and diuretics

2149111

C09DA06 candesartan and diuretics

2149120

C08CA14 cilnidipine and C09CA03 valsartan

2149113

C09DA07 telmisartan and diuretics

Candesartan Cilexetil
Amlodipine Besilate
Telmisartan
Amlodipine BesilateValsartan
Irbesartan
Trichlormethiazide
Candesartan Cilexetil
Hydrochlorothiazide
Cilnidipine
Valsartan
Termisartan
Hydrochlorothiazide
46

Valsartan
2149112

C09DA03 valsartan and diuretics

2149110

C09DA01 losartan and diuretics

Hydrochlorothiazide
Hydrochlorothiazide
Losartan Potassium
2190101
Atorvastatin Calcium Hydrate

2190102
C10BX03 atorvastatin and amlodipine

Amlodipine Besilate

21901032109104* Substances are excepted from the STOPP-J list (Table 3-1 and 3-2).
ATC: Anatomical Therapeutic Chemical Classification System
JAN: Japanese Accepted Names for Pharmaceuticals
1) The first 7-digit numbers of the code of the Japanese drug price list. The drugs with a different compounding ratio of active substances need different codesin the National Health Insurance Drug Price Standard in Japan. For example, there are bland medicinal products with acetylsalicylic acid 330mg for antiinflammatory use (1143010) and 81mg for antiplatelet (3399100).
472) Some combination drugs have individual ATC codes.

48