JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)====================================================================================================================================1

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Greetings from Vas-Cog Japan society
Koji Abe, MD, PhD (President)
After 5 times of annual nationalsymposium from 2010, Vas-Cog Japansociety was formally launched in 2014 forelucidating vascular contribution to AD
development and vascular dementia.
During this 1 year, our society kept
developing with a new journal publication,

also to celebrate thesuccess of Vas-Cog
Asia 4, which was
heldinKuala
Lumpur on October
2. Vas-Cog Asia also
became a formal society

131 active members with 52 council
members, and 20 directors. Based on thegreat contributions of Professors Urakami
K, Hanyu H, Shoji M, and Morishita R,
we are going well for stronger society,promotion, journal publication, andfinance. I greatly thank all of ourmembers, councils, and directors.
Year 2015 was of our great honorable
year, when Vas-Cog Japan 6 jointly heldorganizers and many active members.
Vas-Cog Japan society is dedicated toelucidate the mechanism of vascularfactors on any types of dementia, and tocontribute potential therapy for dementia
people. Many vascular risk factors (VRFs)
suchashypertension(HT),hyperlipidemia(HL,dyslipidemia),
diabetes
mellitus,andmetabolic
syndrome are strongly related both to Ab

meeting with Vas-Cog World 7 at Tokyo
Fashion Town with Professors Yamaguchi
S and Kawabata N as Japan chairpersons
and Professor Nagata K as World
chairperson on September 16-19. We
shared very exciting joint days in a
fashionable Tokyo bay area with many
foreign guests and young/old vas-cog
scientists! I believe this unique joint
meeting strongly promoted mutual

formation and cerebral white matterlesions (WML). Because recent studies
suggest that combination of Aβ deposit
plus small vessel disease is important for
AD phenotype presentation especially inthe very elder societies, we will continue
to study vascular and other risk factors
both for preventing and treating AD andother dementias. I hope you to actively
join our society for fighting against

scientific interests for this field among
more than 500 participants. I would likedementia in aged societies.
December 1, 2015

2with30

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Reports of Vas-Cog Japan 2015
Shuhei Yamaguchi, MD, PhD
Shimane University
Dear Colleagues and Friends,

clinical stage of AD, andThe 6th Vas-Cog Japan was held at Tokyo

suggested

Fashion Town in September 19, 2015. Dr.

importanceKawabata and I organized this year’s

pathology for the ADconference,

wastreatment strategy. The second lectureaccompanied with the Vas-Cog Worldwas by Prof. Kobayashi from Shimane

conference at the same place. Because ofUniversity.

joint hosting, the conference was greatly

importance of assessment and diagnosis

successful,ofof apathy

in treatment

participants was around 150 for thedementia.

TwoJapanese conference. We planned thisincluded regenerative medicine in stroke

congress as a following style, including 2andspecial lectures, 2 educational lectures,

disturbance in stroke patients. Bothand one symposium with 5 speakers. This

lectures were highly impressive andcongress accepted 45 presentations invaluable for future research. In thetotal, in which 11 speakers were assigned

symposium five speakers discussed theirto candidates for a young investigatorown research findings regarding theaward. Two young speakers won the best

prevention

young

vascular dementia. All presentations byandtheandresearcher’s

theconferencenumberaward.

The

first

theoftauHe

networkemphasizedof vascular

educational
analysis

andoflectures
memorypathophysiology

participants

wereWilliam Jagust from UC Berkley. He

impressive.

Aftertalked about recent progress in amyloidparticipants enjoyed the closing party andand tau imaging study with PET. Hea ceremony for awarded young speakers.
Finally,weexcellentofspecial lecture was presented by Prof.

demonstrated

allthethepromised

andconference,reunionindistinct

Kanazawa next year. I greatly appreciate

localization

all the participants for their contributions

and timing ofto the success of the conference.

Aβ and Tau
depositions
depending on3

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

After Vas-Cog Japan2015
Nobuya Kawabata, MD, PhD
Yachiyo Hospital Dementia Center
We held the 6th Japanese Society for

who took charge of

Vascular Cognitive Impairment Vas-Cog

educational lectures

Japan 2015 at the Tokyo Fashion Town onand19th September 2015 with Professor

seminars, where aShuhei

Shimanegreat deal of information about vascular

University of Medicine. This congress

dementia was provided. We had received

started as a study research group in 2010.

overThe society was formed this year, andpresentations.

In particular, the Young

Vas-Cog World was held by Dr. Ken

Investigator’sAwardNagata and Dr. Koji Abe at the same

subject of address of 11 titles, provingtime.

that young doctors are very concerned

Yamaguchi

fromafternoon

40

submissions
(YIA)

for
wasoraltheWe received an enthusiastic speech

about vascular dementia, and indicatingfrom Dr. William Jagust about the role ofgreat energy for the greater development

brain Amyloid and Tau in Aging andof this society in the future.

Alzheimer’s disease at the special lecture

Holdinginconjunction

withthe1 and luncheon seminar. At the special

International Vas-Cog World Conference,lecture 2, we were able to listen to a

however, tended to result in a lesssegment of long-time research regarding

cohesive audience with mixed results.

apathy after apoplexy and Alzheimer

This conference focused on concern for thefrom vascular dementia, with suggested

causes of dementia - not only Alzheimer

importance of caudate nucleus in vasculardementia lesions but vascular dementia

dementia. At the symposium, 5 doctors

lesions. Current trends seem to limit

discussed wide topics from the basics todementia to Alzheimer dementia, thoughclinicalI strongly feel the need to spread theresearch into

predictive andpreventatives for vascular dementia andunderstandingoftheadditional

the clinical state of the disease. In thepossibilities of vascular dementia ormorning seminar, Dr. Mikio Shoji and Dr.

vascular cognitive impairment.

Kenjiro Ono provided insight into theTo end, please allow me to use thislatest knowledge about the origins ofopportunity to offer my sincere thanks toAlzheimer dementia; valuable lectures.

the all of the attendees of this conference.

We deeply appreciate the many doctors
4

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Reports of Vas-Cog Japan 2015
Ken Nagata, MD, PhD
Research Institute for Brain and Blood Vessels

Vas-Cog World 2015 was held at thepresentation in the Educational Course.

Tokyo Fashion Town of Ariake, Koto-ku,

On September 17, Opening Ceremony

Tokyo from September 16, 2016 to 19 days.

was carried out by Ken Nagata, Koji Abe

Although the second day became the largeand Raj Kalaria, The scientific program ofroughness of the weather like typhoons,

Vas-Cog World 2015 has been started.

many researchers that more than 300

Themepeople from Japan and abroad gathered,

Cognitive Disorders" (Chair: Mikio Shoji

it became a very meaningful scientificand Sandra E. Black) was organized by 5meeting.

presentations, and Theme (2) "SmallOn

September

following"Diagnosing

VasculartheVessel Disease and Dementia" (Chair:meeting of STROKOG (Consortium ofKen Nagata and Geert Jan Biessels) in 6Studies

Cognitive

presentations announcement of is it wasDisorders), as a Pre-congress Event, Raj

done. Across the two Luncheon Seminars

Kalaria,Florence

by Abe Koji and Ken Nagata, Poster

Pasquier and Toshiya Fukui made a

Sessions and Poster Review Sessions haveof16,(1)

Post-stroke

MasafumiIhara,

been carried out in the afternoon. In thePoster Session, a total of 159 papers havebeen presented in 27 fields. In the Debate(1)"Do Vascular Risk Factors Make aMajor Contribution to the Etiology ofAlzheimer's

Disease?"(Chair:Issei

Komuro and Raj Kalaria), 4 speakers
made their presentation. Four speakers
5

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Luncheon Seminars by Toshiya Fukui andYasuo Terayama, the Vas-Cog General
Assembly was held in the afternoon.
Subsequently, Poster Session and Poster
Review Session have been carried out.
Fourspeakers

madetheirpresentations in the Debate (2) "Is It
Possible to Prevent MCI from Converting
into AD?" (Chair: Elisabet Englund andpresented their papers in the Young

Shokei

Investigators Meeting (1) "Dementia andVascularRisk

Factors"

Mohammad

Arfan

Ikram

session (2) "Cerebrovascular Impact forAD" (Chair: Masafumi Ihara and Kaavya

Nagao and Shinichiro Uchiyama madepresentations

intheNarasimhalu). In the evening, following

Evening

the Evening Seminar by Ken Nagata, theSeminars.

Banquet was carried out in TOC West

The Scientific program of the third day,Tower.

September 18th, was started with theThe program of September 19, wasTheme (3) "Vascular Factors in AD andstarted

Other Dementia" (Chair: Raj Kalaria, and6presentations

subsequently,Across(5)presentations. Subsequently, 6 speakers
made their presentations in the Themeand Risk Factors" (Chair: Tsong-Hai LeeMizuno).

ThemeO'Brien) which was organized by 6

Theme (4) "Post-stroke Dementia, CCA
ToshikitheFactors" (Chair: Ingmar Skoog and John

6speakers made their presentations in theandwith"Neuropsychiatric Diseases and VascularRyuichi Morishita) which was organizedbyspeakersInvestigators Meeting Young researchers

ToruYamashita). In the evening, Takehiko
theirThreepresented their papers in the Young(Chair:andMitsuyama).

(6)the"Emerging

Biomarker

6for

Neuroimaging
Dementia"and(Chair:JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT
Christopher Chen and Hidekazu
Tomimoto). After the Luncheon
Seminar by Ryuichi Morishita,
KenNagataandKoji

Abeconcluded the meeting at theclosing seremony, and all of theprograms of Vas-Cog 2015 havebeen completed.
On behalf of the executive
committee of Vas-Cog 2015, wewould like to thank from myheart to all participants and thestaff.
※ This text was described byomitting the title of presentersand chair persons.

7(2015 No.2)

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

An impression on Vas-Cog Asia
Shinichiro Uchiyama, MD, PhD
International University of Health and Welfare
Sanno Hospital and Sanno Medical Center
The Vas-Cog Asia 4 was held as a joint
conference with the Asia Pacific Stroke
Conference (APSC) 2015 in Kuala
Lumpur in the afternoon on October 2 asin the previous three conferences. Therewere variety of presentations in thisconference even more than in the former
conference. Concerning the correlation
between cognitive impairment andcerebrovascular disease, many new
aspects of basic science, pathophysiology,epidemiology, imaging, prevention, andtreatment were presented and muchargued. In the Session of Young Flash
Talk, young Asian researchers presented
interestingworks,
whichweresuccessfully congratulated. Dementia andstroke are two major disabling diseases,
which shorten healthy lifespan, and arecontinuouslyincreasinginAsia.
Therefore, Vas-Cog Asia will become moremeaningful conference and society infuture.
World Stroke Day Proclamation byWorld Stroke Organization (WSO) was“Stroke and Potentially PreventableDementia”. In this proclamation, WSO
emphasizes to prevent, identify, and treat

potentiallypreventabledementia.
Theproclamation notesthat
subclinical(“silent”) strokes occur five times as often
as clinical (obvious) strokes, and may
affect thinking, mood, and personality. It
also notes that all major dementias havea vascular component including 80% in
Alzheimer disease. Asia Pacific Stroke
Organization (APSO) has recently beenrecognized as the local organization of
WSO in Asia. Therefore, Vas-Cog Asia
holding a joint conference with APSC
should also develop promotion activities
for preventable dementia.
The next Vas-Cog Asia will be held inBrisbane, Australia in the afternoon on
July 14 again as the Joint Conferencewith APSC 2016. Brisbane is the third
biggest city in Australia with populationof two million, and very popular among
tourists because of warm ever weather
and well known adjacent resorts such asGold Coast. We are looking forward toseeing many of you in Vas-Cog Asia 5.

8JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Welcome to Vas-Cog Japan 2016

Masahito Yamada, MD, PhD

Masatsugu Horiuchi, MD, PhD

Kanazawa University

Ehime UniversitySince

We are pleased to welcome you to thestartingoperations

Vas-Cog Japan 2016 to be held at thesuperexpress

Kanazawa Miyako Hotel, August 6, 2016.

Tokyo and Kanazawa in March 2015,

This is the first time that the meeting isaccess to the conference venue is muchheld in the local city other than Tokyo or

easier than before.

Kyotoand traditional culture are still preservedsincetheSociety

hasbeenin Kanazawa.

established in 2010.
has

including Japan.

betweenOld-fashioned town

Fruitful discussion at theVas-Cog 2016 could be a first step to

The number of patients suffering fromdementia(Shinkansen)

ofworldwide

overcome vascular cognitive impairments.

Major causes of the

Furthermore, we also would like every

soaredindementia are Alzheimer’s disease andparticipant to enjoy the historic city.

vascular dementia.

In the Vas-Cog

are looking forward to seeing you inJapan

have

Kanazawa.

2016,

wedecided“Cardiovascular and metabolic disorders
and dementia, and cerebral amyloid
angiopathy (CAA)” as a theme.

Wewould like to focus on relationshipbetween CAA, Alzheimer’s disease, andinflammation,

inaddition

topathomechanisms of vascular dementia inrelation to cardiovascular and metabolicdisorders.
9We

JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

The 7th Board Member meeting for Japan Vas-Cog was held on
the 18th of September, 2015 in Tokyo, with 14 board members.
Ryuichi Morishita, MD, PhD
Osaka University
The titles of the meeting were “ThePlanforFuture
Conferences,”“Preparation for Forming a Society.”
Following is a report of the meeting, withdiscussed were plans
foradditional
documentation by thenextconference.

the topics discussed and plans approved.
[Membership]
131 regular members (10th September,2015)[Report from each chairman]*The chairperson for the promotion of
becoming a society, Dr. Katsuya Urakami,
discussed the difficulties of forming asociety due to membership number andthe need to confirm the criteria for

There are also plansfor one more auditor in addition to Dr.
Matsubara.
[Plans for future conferences]
The 7th conference (August 6th, 2016:Kanazawa Miyako Hotel) organizers: Dr.
Masatsugu Horiuchi and Dr. Masahito
YamadaThe 8th conference (August 5th, 2017:
Toranomon Hills, Toyko) organizers: Dr.

formation.
*Thechairperson
forincreasing
membership and public relations, Dr.
Haruo
Hanyu,
discussed
greaterpromotion of membership through amailing list. A prospectus will be createdand published for homepage banneradvertisement.
*The chief editor of the academic

Shinichiro Uchiyama, Dr. Issei Komuro,andVice-Chairperson
Dr.
Kazuo
Kitagawa
The 9th conference (2018) organizers: Dr.
Katsuya Urakami and Dr. Etsuro
Matsubara
The 10th conference (2019) organizers: Dr.
Masahiro Akishita and Dr. Yoshio Ikeda
Vas-Cog Asia 4 in conjunction withmagazine, Dr. Mikio Shoji, discussed
publishing a second volume of theperiodical for the organization following
the conference (each section will becontacted appropriately).
*The chairperson of financial affairs, Dr.
Ryuichi Morishita, reported on thefinancial accounting and discussed theformation of a society this year. Also(APSC2015) in Kuala Lumpur andOctober 2nd, 2015, Shangri La Hotel(Kuala Lumpur, Malaysia)
Chair: Koji Abe, Ramesh Sahathevan,and Christopher Chen
[COI]We are planning consideration of
COI and creating a standard comparable
to other similar societies.

10JAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)[Name list]

Syunya Takizawa (Tokai University)●Executive Advisor

Yasuo

Hiroshi Mori (Osaka City University)

University)●President

Hidekazu Tomimoto (Mie University)

Koji Abe (Okayama University)

Ken Nagata (Research Institute for Brain●Executive Directors

and Blood Vessels)

Masahiro Akishita (The University ofHaruo Hanyu (Tokyo Medical University)

Tokyo)

Toshiya

Yoshio Ikeda (Gunma University)

Hospital)

Shinichiro

Masatsugu Horiuchi (Ehime University)

Uchiyama(InternationalTerayamaFukui(Iwate(Kawasaki

MedicalMemorial

University of Health and Welfare)

Etsuro Matsubara (Oita University)

Katuya Urakami (Tottori University)

ToshikiNobuya Kawabata (Yachiyo Hospital)

University of Medicine)

Kazuo Kitagawa (Tokyo Women's Medical

ShokeiUniversity)

University)

Koichi Kozaki (Kyorin University)

Masaru Mimura (Keio University)

Issei Komuro (The University of Tokyo)

Ryuichi Morishita (Osaka University)

Masataka Sata (Tokushima University)

Shuhei Yamaguchi (Shimane University)

Mikio Shoji (Hirosaki University)

Masahito Yamada (Kanazawa University)

Masahiko Suzuki (The Jikei UniversitySchool of Medicine)

11Mizuno(KyotoMitsuyama

Prefectural(KumamotoJAPANESE SOCIETY OF VASCULAR COGNITIVE IMPAIRMENT(2015 No.2)

Editors NoteMikio Shoji MD., PhD.,
Hirosaki University
Since Vas-Cog Japan has developed tobe official academic society, News andLetter is also changed to the Vas-Cog
Journal as the official journal of Vas-Cog
Japan Society. Here, we bring you the2nd issue, No.2. We would like to provide
information of VAS-Cog Japan Society,annual meeting and to publish originalarticle about vascular dementia study inthe future. CONET Co., Ltd. manages
society secretary works.
In this issue, we reported the 6th
annual meeting of Vas-Cog Japan 2015,
which was held in TOKYO fashion town
on September 19, by Dr. Shuhei
Yamaguchi in Shimane University and Dr.
Shinya Kawabata in Yachiyo Hospital.
About
150
participantsand45
presentations, plenary lectures andspecial lectures and symposium were very
impressive, suggesting marked progressin our society. Since Vas-cog world 2015

washeldsimultaneously,
6th
annualmeeting of Vas-cog
Japanwasinternational andmemorable. Many researchers in Vas-Cog
world also joined Vas-Cog Japan.
Vas-Cog World 2015 was held by Dr.
Ken Nagata and Koji Abe in September
16-19 in the same venue. About 300
researches participated the meeting andsuccessfully closed. Dr. Nagata reported
the Vas-Cog world 2015 and Dr.
Uchiyama also reported the Vas-cog Asia
2015. Based on these reports, we noticed
the developing of this field in the world.
Next 7th annual meeting of Vas-Cog
Japan will be held in Kanazawa city,
August. I am looking forward to seeing
many members in Vas-cog Japan 2016, inKanazawa.

The past and future annual meetings of Vas-Cog JapanThe 1st Meeting : August, 2010 (Tokyo) Chairmen : Ken Nagata and Toshiya Fukui
The 2nd Meeting : August, 2011 (Tokyo) Chairmen : Koji Abe and Shokei Mitsuyama
The 3rd Meeting : August, 2012 (Tokyo) Chairmen : Ryuichi Morishita, Yasuo Terayama, and Koji
Abe
The 4th Meeting : August, 2013 (Tokyo) Chairmen : Mikio Shoji and Haruo Hanyu
The 5th Meeting : August, 2014 (Kyoto) Chairmen : Toshiki Mizuno and Hidekazu Tomimoto
The 6th Meeting : August, 2015 (Tokyo) Chairmen : Shinya Kawabata and Shuhei Yamaguchi
The 7th Meeting : August, 2016 (Kanazawa) Chairmen : Masatsugu Horiuchi and Masahito Yamada
The 8th Meeting : August, 2017 (Tokyo) Chairmen : Shinichiro Uchiyama and Issei Komuro
The 9th Meeting : August, 2018 (planned) Chairmen : Katsuya Urakami and Etsuro Matsubara
The 10th Meeting : August, 2019 (planned) Chairmen : Masahiro Akishita and Yoshio Ikeda- to be continued-

12