履歴書

澤間善成 (Yoshinari Sawama)
2021.4.1

平成１３年３月

大阪大学薬学部製薬化学科

卒業

平成１３年４月

大阪大学大学院薬学研究科博士前期課程

入学

平成１５年３月

大阪大学大学院薬学研究科博士前期課程修了

平成１５年４月

大阪大学大学院薬学研究科博士後期課程

入学

平成１８年３月

大阪大学大学院薬学研究科博士後期課程修了

平成１７年４月

日本学術振興会特別研究員 (DC2)

平成１８年３月 大阪大学大学院薬学研究科分子薬科学専攻博士後期課程
平成１８年４月

日本学術振興会特別研究員（PD）

平成１９年４月

独国ドルトムント工科大学化学科博士研究員

平成２１年４月

立命館グローバルイノベーション研究機構博士研究員

兼大阪大学大学院薬学研究科特任助教

平成２２年２月

岐阜薬科大学・助教

平成２７年１０月

岐阜薬科大学・講師

平成２９年７月

岐阜薬科大学・准教授

令和３年４月修了

大阪大学大学院薬学研究科・准教授

現在に至る----------------------------------------------------------------------------------------------------------------------------------[原著論文]
1) Copper-Catalyzed Aqueous N–O Bond Cleavage of 2-Oxa-3-Azabicyclo Compounds to Cyclic cis-1,4Amino Alcohols
N. Yasukawa, Y. Miki, M. Kuwata, H. Sajiki* Y. Sawama*
ChemSusChem, 13, 5632-5637 (2020).
Selected as a Cover Feature.
2) Hydroquinone and Benzoquinone-Catalyzed Aqueous Knoevenagel Condensation
R. Takakura, K. Koyama, M. Kuwata, T. Yamada, H. Sajiki* Y. Sawama*
Org. Biomol. Chem., 18, 6594-6597 (2020).
Selected as a HOT article colelction and Editor’s collection.
3) Palladium on Carbon–Catalyzed Oxidative Transformation of Benzylic Ethers
R. Takakura, S. Kuwata, K. Nakano, N. Yasukawa, H. Sajiki,* Y. Sawama*
Heterocycles, in press (Special Issue Vol. 103 in honor of Professor Yasuyuki Kita on 77th Birthday) DOI:
10.3987/COM-20-S(K)25 (2020).
4) One-pot Heteroarene Synthesis Based on Ruthenium-on-Carbon-Catalyzed Oxidative Aromatization using
OxygenY. Yamamoto, Y. Yamada, H. Sajiki,* Y. Sawama*
Bull. Chem. Soc. Jpn., 93, 1419-1423 (2020).
15) Improvement Parameters of Hydrogen Generation from Water under Stainless-steel-Mediated Ball Milling
Conditions
M. Itoh, Y. Sawama,* M. Niikawa, K. Ban, T. Kawajiri, H. Sajiki*
Bull. Chem. Soc. Jpn., 93, 1366-1371 (2020).
6) Quantitative Mechanochemical Methanation of CO2 with H2O in a Stainless Steel Ball MillY. Sawama,* M. Niikawa, K. Ban, K. Park, S. Aibara, M. Itoh, H. Sajiki*
Bull. Chem. Soc. Jpn., 93, 1074-1078 (2020).
Selected as a Selected paper.
7) Arylation of Indoles Using Cyclohexanones Dually-Catalyzed by Niobic Acid and Palladium-on-Carbons
K. Ban, Y. Yamamoto, H. Sajiki,* Y. Sawama*
Org. Biomol. Chem., 18, 3898-3902 (2020).
8) Practical and reliable synthesis of 2′,3′,5′,5′′-tetradeuterated uridine derivatives
N. Miyamoto, H. Ohno, Y. Kitamura, K. Park, Y. Sawama, H. Sajiki, Y. Kitade*
Nucleosides, Nucleotides & Nucleic Acids, 39, 236-244 (2020).
9) Preparation of N2-Ethyl-2'-deoxyguanosine-d4 as an Internal Standard for the Electrospray IonizationTandem Mass Spectrometric (ESI-MS/MS) Determination of DNA Damage by Acetaldehyde
Y. Esaka,* H. Aruga, S. Kunishima, T. Yamamoto, H. Murakami, Y. Sawama, H. Sajiki H, B. Uno
Anal., Sci., 36, 877-880 (2020).
10) N-Heterocyclic carbene-catalyzed deuteration of aldehydes in D2O
Y. Sawama,* Y. Miki, H. Sajiki*
Synlett, 31, 699-702 (2020).
11) Facile Hydrogenative Deprotection of N-Benzyl Groups Using a Mixed Catalyst of Palladium andNiobic Acid on Carbon
Y. Yamamoto, E. Shimizu, K. Ban, Y. Wada, T. Mizusaki, M. Yoshimura, Y. Takagi, Y. Sawama,* H.
Sajiki*ACS Omega, 5, 2699−2709 (2020).
12) PLATINUM ON CARBON–CATALYZED AND CHEMOSELECTIVE AQUEOUS OXYGENOXIDATION OF AROMATIC ACETALS TO BENZOIC ACIDS
N. Yasukawa, T. Matsuda, E. Shimizu, H. Sajiki,* Y. Sawama*
Heterocycles, 100, 145-152 (2020).
13) Platinum on carbon-catalyzed aqueous oxidative lactonization of diols using molecular oxygen
R. Takakura, K. Ban, H. Sajiki,* Y. Sawama*
Synlett, 30, 1919-1923 (2019).
14) Birch-Type Reduction of Arenes in 2-Propanol Catalyzed by Zero-Valent Iron and Platinum on Carbon
Y. Sawama,* K. Ban, K. Akutsu-Suyama, H. Nakata, M. Mori, T. Yamada, Ta. Kawajiri, N. Yasukawa, K.
Park, Y. Monguchi, Y. Takagi, M. Yoshimura, H. Sajiki*
ACS Omega, 4, 11522-11531 (2019).
15) Acetal Elimination Reaction Accompanied with Regioselective Ring Opening of 1,4-Bisacetal-1,4epoxy-1,4-dihydronaphthalenes
2

Y. Sawama,* T. Kawajiri, Y. Yamamoto, Y. Shishido, R. Goto, H. Sajiki*
Heterocycles, (Special Issue Vol. 99 in honor of Professor Tohru Fukuyama on 70th Birthday ), 99, 126133 (2019).
16) H-D Exchange Deuteration of Arenes at Room Temperature
Y. Sawama,* A. Nakano, T. Matsuda, T. Kawajiri, T. Yamada, H. Sajiki*
Org. Process Res. Dev., 23, 648-653 (2019).
17) Chemoselective Nucleophilic Functionalizations of Aromatic Aldehydes and Acetals via Pyridinium Salt
Intermediates
T. Kawajiri, M. Kato, H. Nakata, R. Goto, S. Aibara, R. Ohta, H. Fujioka, H. Sajiki,* Y. Sawama*
J. Org. Chem., 84, 3853-3870 (2019). IF:
Selected as cover picture.
18) Microwave-mediated site-selective heating of spherical-carbon-bead-supported platinum for thecontinuous, efficient catalytic dehydrogenative aromatization of saturated cyclic hydrocarbons
T. Ichikawa, T. Matsuo, T. Tachikawa, T. Yamada, T. Yoshimura, M. Yoshimura, Y. Takagi, Y. Sawama, J.
Sugiyama, Y. Monguchi, H. Sajiki*
ACS Sustain. Chem. Eng., 7(3), 3052-3061 (2019).
19) Development of Titanium Dioxide-Supported Pd Catalysts for Ligand-Free Suzuki-Miyaura Coupling ofAryl Chlorides
T. Yamada, H. Masuda, K. Park, T. Tachikawa, N. Ito, T. Ichikawa, M. Yoshimura, Y. Takagi, Y. Sawama,
Y. Ohya H. Sajiki*
Catalysts, 9(5), 461 (2019).
20) Application of Thiol-Modified Dual-Pore Silica Beads as Practical Scavenger of Leached Palladium
Catalyst in C-C Coupling Reaction
T. Yamada, T. Matsuo, A. Ogawa, T. Ichikawa, Y. Kobayashi, H. Masuda, R. Miyamoto, H. Bai, K.
Meguro, Y. Sawama, Y. Monguchi, H. Sajiki*
Org. Process Res. Dev., 23, 462-469 (2019).
21) Polyethyleneimine-modified Polymer as an Efficient Palladium Scavenger and Effective Catalyst
Support for a Functional Heterogeneous Palladium Catalyst
T. Yamada, Y. Kobayashi, N. Ito, T. Ichikawa, K. Park, K. Kunishima, S. Ueda, M. Mizuno, T. Adachi, Y.
Sawama, Y. Monguchi, H. Sajiki*
ACS Omega, 46, 10243-10251 (2019).
22) Microwave-Mediated Continuous Hydrogen Abstraction Reaction from 2-PrOH Catalyzed by Platinumon Carbon Bead
T. Ichikawa, T. Matsuo, T. Tachikawa, W. Teranishi, T. Yamada, Y. Sawama,Y. Monguchi, H. Sajiki*
Catalysts, 9, 655 (2019).
23) Copper-catalyzed pyrrole synthesis from 3,6-dihydro-1,2-oxazines
N. Yasukawa, M. Kuwata, T. Imai, Y. Monguchi, H. Sajiki,* Y. Sawama*
Green Chem., 20, 4409-4413 (2018).
Selected as an inside cover.
Highlighted in Synfacts 2019; 15(01): 0074.
324) Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in
Deuterium Oxide
K. Park, T. Matsuda, T. Yamada, Y. Monguchi, Y. Sawama, N. Doi, Y. Sasai, S. Kondo, Y. Sawama,* H.
Sajiki*Adv. Synth. Catal., 360, 2303-2307 (2018).
25) Stainless Steel-Mediated Hydrogen Generation from Alkanes and Diethyl Ether and Its Application for
Arene Reduction
Y. Sawama,* N. Yasukawa, K. Ban, R. Goto, M. Niikawa, Y. Monguchi, M. Itoh, H. Sajiki*
Org. Lett., 20, 2892-2896 (2018).
26) Highly-functionalized arene synthesis based on palladium on carbon-catalyzed aqueous dehydrogenationof cyclohexadienes and cyclohexenes
N. Yasukawa, H. Yokoyama, M. Masuda, Y. Monguchi, H. Sajiki,* Y. Sawama*
Green Chem., 20, 1213-1217 (2018).
27) Aromatic Aldehyde-Selective Aldol Addition with Aldehyde-Derived Silyl Enol Ethers
T. Kawajiri, R. Ohta, H. Fujioka, H. Sajiki,* Y. Sawama*
Chem. Commun., 54, 374-377 (2018).
28) Organocatalytic Nitroaldol Reaction Associated with Deuterium-Labeling
T. Yamada, M. Kuwata, . Takakura, Y. Monguchi, H. Sajiki,* Y. Sawama*
Adv. Synth. Catal., 360, 637-641 (2018).
29) Selective N-Mono-Alkylation of Amide Derivatives using Trialkyl Phosphates
S. Asai, K. Ban, Y. Monguchi, H. Sajiki,* Y. Sawama*
Synlett, 29, 322-325 (2018).
30) A practical method for heterogeneously-catalyzed Mizoroki–Heck reaction: flow system with adjustmentof microwave resonance as an energy source
T. Ichikawa, M. Mizuno, S. Ueda, N. Ohneda, H. Odajima, Y. Sawama, Y. Monguchi,* H. Sajiki*
Tetrahedron, 74, 1810-1816 (2018).
31) Selective Synthesis of Primary Amines from Nitriles under Hydrogenation Conditions
M. Yoshimura,* A. Komatsu, M. Niimura, Y. Takagi, T. Takahashi, S. Ueda, T. Ichikawa, Y. Kobayashi, H.
Okami, T. Hattori, Y. Sawama, Y. Monguchi,* H. Sajiki*Adv. Synth. Catal., 360, 1726-1732 (2018).
32) Heterogeneous Copper-Catalyzed Synthesis of S-Arylated 2-Aminothiophenols via Ring Opening of
Benzothiazoles and C-S Coupling Using Aryl Halides
T. Ichikawa, T. Matsuo, T. Tachikawa, Y. Sawama, Y. Monguchi, H. Sajiki*
Heterocycles (Special Issue Vol. 97 in honor of Professor Kiyoshi Tomioka on 70th Birthday ), 97, 793805 (2018).
33) Palladium on Carbon-Catalyzed Benzylic Methoxylation for Synthesis of Mixed Acetals and Orthoesters
N. Yasukawa, T. Kanie, M. Kuwata, Y. Monguchi, H. Sajiki,* Y. Sawama*
Chem. Eur. J., 23, 10974-10977 (2017).
Selected as a Hot paper.
434) Cyclic Ether Synthesis from Diols using Trimethyl Phosphate
S. Asai, M. Kato, Y. Monguchi, H. Sajiki,* Y. Sawama*
Chem. Commun., 53, 4787-4790 (2017).
35) Phosphate-Mediated Enyne Synthesis from Allenols
S. Asai, M. Kato, Y. Monguchi, H. Sajiki,* Y. Sawama*
ChemistrySelect, 2, 876-878 (2017).
36) Heterogeneous one-pot carbonylation and Mizoroki-Heck reactions in a parallel manner following thecleavage of cinnamaldehyde derivatives
T. Hattori, S. Ueda, R. Takakura, Y. Sawama, Y. Monguchi, H. Sajiki*Chem. Eur. J., 23, 8196-8202 (2017).
37) Ruthenium on carbon catalysed carbon-carbon cleavage of aryl alkyl ketones and aliphatic aldehydes inaqueous media
T. Hattori, H. Okami, T. Ichikawa, S. Mori, Y. Sawama, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 359, 3490-3495 (2017).
38) Catalyst-dependent selective hydrogenation of nitriles: Selective synthesis of tertiary and secondaryaminesY. Monguchi, M. Mizuno, T. Ichikawa, Y. Fujita, E. Murakami, T. Hattori, T. Maegawa, Y. Sawama, H.
Sajiki*J. Org. Chem., 82, 10939-10944 (2017).
39) Development of a unique heterogeneous palladium catalyst for Suzuki-Miyaura reaction using(hetero)aryl chlorides and chemoselective hydrogenation
T. Ichikawa, M. Netsu, M, Mizuno, T, Mizusaki, Y, Takagi, Y. Sawama, Y, Monguchi, H, Sajiki*Adv. Synth. Catal., 359, 2269–2279 (2017).
40) Amphipathic monolith-supported palladium catalysts for chemoselective hydrogenation and crosscoupling reactions
Y. Monguchi,* F. Wakayama, S. Ueda, R. Ito, H. Takada, H. Inoue, A. Nakamura, Y. Sawama, H. Sajiki*
RSC Adv., 7, 1833-1840 (2017).
41) Site-Selective Iron(III) Chloride-Catalyzed Arylation of 4-Aryl-4-methoxy-2,5-cyclohexadienones for
the Synthesis of Polyarylated Phenols
Y. Sawama,* M. Masuda, R. Nakatani, H. Yokoyama, Y. Monguchi, T. Dohi, Y. Kita, H. Sajiki*Adv. Synth. Catal., 358, 3683-3687 (2016).
Selected as a Very Important Publication (VIP) and a cover picture.
42) Additional Nucleophile-Free FeCl3-Catalyzed Green Deprotection of 2,4-DimethoxyphenylmethylProtected Alcohols and Carboxylic Acids
Y. Sawama,* M. Masuda, A. Honda, H. Yokoyama, K. Park, N. Yasukawa, Y. Monguchi, H. Sajiki*Chem. Pharm. Bull., 64, 778 (2016).
43) Palladium on Carbon-Catalyzed Chemoselective Oxygen Oxidation of Aromatic Acetals
N. Yasukawa, S. Asai, M. Kato, Y. Monguchi, H. Sajiki,* Y. Sawama*
Org. Lett., 18, 5604-5607 (2016).
544) Disiloxane Synthesis Based on Silicon-Hydrogen Bond Activation Using Gold and Platinum on Carbon
in Water or Heavy Water
Y. Sawama,* M. Masuda, N. Yasukawa, R. Nakatani, S. Nishimura, K. Shibata, T. Yamada, Y. Monguchi,
H. Suzuka, Y. Takagi, H. Sajiki*
J. Org. Chem.,. 81, 4190-4195 (2016).
45) Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids
T. Yamada, K. Park, N. Yasukawa, K. Morita, Y. Monguchi, Y. Sawama,* H. Sajiki*Adv. Synth. Catal., 358, 3277-3282 (2016).
46) Palladium on Carbon-Catalyzed C-H Amination for Synthesis of Carbazoles and its Mechanistic Study
Y. Monguchi,* H. Okami, T. Ichikawa, K. Nozaki, T. Maejima, Y. Oumi, Y. Sawama, H. Sajiki*Adv. Synth. Catal., 358, 3145-3451 (2016).
47) Palladium-Catalyzed C-H Monoalkoxylation of α,β-Unsaturated Carbonyl Compounds
Y. Monguchi,* K. Kunishima, T. Hattori, T. Takahashi, Y. Shishido, Y. Sawama, H. Sajiki*
ACS Catal., 6, 3994-3997 (2016).
48) Switching the cleavage sites in palladium on carbon-catalyzed carbon–carbon bond disconnection
T. Hattori,* R. Takakura, T. Ichikawa, Y. Sawama, Y. Monguchi, H. Sajiki*
J. Org. Chem., 81, 2737-2743 (2016).
49) Gold-Catalyzed Benzylic Azidation of Phthalans and Isochromans and Subsequent FeCl3-Catalyzed
Nucleophilic Substitutions
S. Asai, Y. Yabe, R. Goto, S. Nagata, Y. Monguchi, Y. Kita, H. Sajiki,*Y. Sawama*
Chem. Pharm. Bull., 63, 757-761 (2015).
50) FeCl3-Catalyzed Self-Cleaving Deprotection of Methoxyphenylmethyl-Protected Alcohols
Y. Sawama,*M. Masuda S. Asai, R. Goto, S. Nagata, S. Nishimura, Y. Monguchi, H. Sajiki*
Org. Lett., 17, 434-437 (2015).
51) Biaryl Synthesis by Ring-Opening Friedel–Crafts Arylation of 1,4-Epoxy-1,4-dihydronaphthalenes
Catalyzed by Iron Trichloride
Y. Sawama,* S. Asai, T. Kawajiri, Y. Monguchi, H. Sajiki*Chem. Eur. J., 21, 2222-2229 (2015).
52) Biarylmethane and Fused Heterocyclic Arene Synthesis via in Situ Generated o- and/or pNaphthoquinone Methides
Y. Sawama,* T. Kawajiri, S. Asai, N. Yasukawa, Y. Shishido, Y. Monguchi, H. Sajiki*
J. Org. Chem., 80, 5556-5565 (2015).
53) Stainless-Steel-Mediated Quantitative Hydrogen Generation from Water under Ball Milling Conditions
Y. Sawama,* M. Niikawa, Y. Yabe, R. Goto, T. Kawajiri, T. Marumoto, T. Takahashi, M. Itoh, Y. Kimura,Y. Sasai, Y. Yamauchi, S. Kondo, M. Kuzuya, Y. Monguchi, H. Sajiki
ACS Sustainable Chem. Eng., 3, 683-689 (2015).
Highlighted in Yomiuri Shimbun (15th, March, 2017) and Gifu Shimbun (22th, December, 2016).
54) Stainless-Steel Ball Milling Method for Hydro-/Deutero-genation using H2O/D2O as a
Hydrogen/Deuterium Source
6

Y. Sawama,* T. Kawajiri, M. Niikawa, R. Goto, Y. Yabe, T. Takahashi, T. Marumoto, M. Itoh, Y. Kimura,Y. Monguchi, S. Kondo, H. Sajiki
ChemSusChem, 8, 3773-3776 (2015).
55) Palladium on Carbon-Catalyzed Aqueous Transformation of Primary Alcohols to Carboxylic Acids
Based on Dehydrogenation under Mildly Reduced Pressure
Y. Sawama,* K. Morita, S. Asai, M. Kozawa, S. Tadokoro, J. Nakajima, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 357, 1206-1210 (2015).
Highlighted in synfacts, 11, 0783 (2015); highlighted in Organic Chemistry Portal, March 14 (2016).
56) Hydrogen Self-Sufficient Arene Reduction to Cyclohexane Derivatives Using a Combination of
Platinum on Carbon and 2-Propanol
Y. Sawama,* M. Mori, T. Yamada, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 357, 3667-3670 (2015).
Selected as an inside cover picture.
57) Multiple Deuteration of Alkanes Synergistically Catalyzed by Platinum and Rhodium on Carbon as aMixed Catalytic System
T. Yamada, Y. Sawama,* K. Shibata, K. Morita, Y. Monguchi, H. Sajiki*
RSC Adv., 5, 13727-13732 (2015).
58) Mild Deuteration Method of Terminal Alkynes in Heavy Water Using Reusable Basic Resin
T. Yamada, K. Park, Y. Monguchi, Y. Sawama,* H. Sajiki*
RSC Adv., 5, 92954-92957 (2015).
59) Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous
Flow System
T. Hattori, A. Tsubone, Y. Sawama, Y. Monguchi, H Sajiki*
Catalysts, 5, 18-25 (2015).
60) Practical remediation of the PCB-contaminated soils
A. Ido, M. Niikawa, S. Ishihara, Y. Sawama, T. Nakanishi, Y. Monguchi, H. Sajiki, H. Nagase*
J. Environ. Health Sci. Eng., 13:9 (2015).
61) Osmium on Chelate Resin: Nonvolatile Catalyst for the Synthesis of Diols from Alkenes
Y. Monguchi, F. Wakayama, H. Takada, Y. Sawama, H. Sajiki*
Synlett, 26, 700-704 (2015).
62) Facile Arene Hydrogenation under Flow Conditions Catalyzed by Rhodium or Ruthenium on Carbon
T. Hattori, T. Ida, A. Tsubone, Y. Sawama, Y. Monguchi, H. Sajiki*
Eur. J. Org. Chem., 2492-2497 (2015).
63) Unique Chemoselective Hydrogenation Using Palladium Catalyst Immobilized on Ceramic
Y. Monguchi, T. Marumoto, T. Ichikawa, Y. Miyake, Y. Nagae, M. Yoshida, Y. Oumi, Y. Sawama, H.
Sajiki*
ChemCatChem, 7, 2155-2160 (2015).
64) Development of Chelate Resin-Supported Palladium Catalysts for Chemoselective Hydrogenation
Y. Monguchi, T. Ichikawa, K. Nazaki, K. Kihara, Y. Yamada, Y. Miyake, Y. Sawama, H. Sajiki*7Tetrahedron, 71, 6499-6505 (2015).
65) Tertiary-Amino-Functionalized Resin-Supported Palladium Catalyst for the Heterogeneous Suzuki–
Miyaura Reaction of Aryl Chlorides
Y. Monguchi,T. Ichikawa, M. Netsu, T. Hattori, T. Mizusaki, Y. Sawama, H. Sajiki*
Synlett, 26, 2014-2018 (2015).
66) Effect of sodium acetate in atom transfer radical addition of polyhaloalkanes to olefins
Y. Sawama,* R. Nakatani, T. Imanishi, Y. Fujiwara, Y. Monguchi, H. Sajiki*
RSC Adv., 4, 8657-8660 (2014).
67) Efficient Partial Hydrogenation of Trichloromethyl to gem-Dichloromethyl Groups in Platinum on
Carbon-Catalyzed System
Y. Sawama,* T. Imanishi, R. Nakatani, Y. Fujiwara, Y. Monguchi, H. Sajiki*
Tetrahedron, 70, 4540-4546 (2014).
Highlighted in J. Synth. Org. Chem., Jpn, 73, 88 (2015).
68) Rhodium on Carbon-Catalyzed Hydrogen Scavenger- and Oxidant-free Dehydrogenation of Alcohols in
Aqueous MediaY. Sawama,* K. Morita,T. Yamada, S. Nagata, Y. Yabe, Y. Monguchi, H. Sajiki*
Green Chem., 16, 3439-3443 (2014).
Highlighted in J. Synth. Org. Chem., Jpn, 72, 1175 (2014).
69) Iron-Catalyzed Friedel–Crafts Benzylation with Benzyl TMS Ethers at Room Temperature
Y. Sawama,* Y. Shishido, T. Kawajiri, R. Goto, Y. Monguchi, H. Sajiki*Chem. Eur. J., 20, 510-516 (2014).
70) Chemoselective and Direct Functionalization of Methyl Benzyl Ethers and Unsymmetrical Dibenzyl
Ethers by Using Iron Trichloride
Y. Sawama,* R. Goto, S. Nagata, Y. Shishido, Y. Monguchi, H. Sajiki*Chem. Eur. J., 20, 2631-2636 (2014).
71) Palladium on Carbon-Catalyzed Gentle and Quantitative Combustion of Hydrogen at Room Temperature
Y. Monguchi, T. Ida, T. Maejima, T. Yanase, Y. Sawama, Y. Sasai, S. Kondo, H Sajiki*Adv. Synth. Catal., 356, 313-318 (2014).
72) Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions
T. Hattori, A. Tsubone, Y. Sawama, Y. Monguchi, H. Sajiki*
Tetrahedron, 70, 4790-4798 (2014).
73) Palladium on Carbon-Catalyzed One-Pot N-Arylindole Synthesis: Intramolecular Aromatic Amination,
Aromatization, and Intermolecular Aromatic Amination
Y. Monguchi, T. Marumoto, H. Takamatsu, Y. Sawama, H. Sajiki*Adv. Synth. Catal., 356, 1866-1872 (2014).
74) Efficient Generation of ortho-Naphthoquinone Methides from 1,4-Epoxy-1,4-dihydronaphthalenes andTheir Annulation with Allyl Silanes
Y. Sawama,* Y. Shishido, T. Yanase, K. Kawamoto, R. Goto, Y. Monguchi, Y. Kita, H. Sajiki*
Angew. Chem. Int. Ed., 52, 1515-1519 (2013).
875) Iron-Catalyzed Ring-Opening Azidation and Allylation of O-Heterocycles
Y. Sawama,* K. Shibata, Y. Sawama, M. Takubo, Y. Monguchi, N. Krause, H. Sajiki*
Org. Lett., 15, 5282-5285 (2013).
76) Lewis Acid-Catalyzed Ring-Opening Functionalizations of 1,4-Epoxy-1,4-dihydronaphthalenes
Y. Sawama,* Y. Ogata, K. Kawamoto, H. Satake, K. Shibata, Y. Monguchi, H. Sajiki, Y. Kita*
Adv. Synth. Catal., 355, 517-528 (2013).
77) Site-selective Deuterated-Alkene Synthesis Using Palladium on Boron Nitride
Y. Yabe, Y. Sawama, Y. Monguchi, H. Sajiki*Chem. Eur. J., 19, 484-488 (2013).
78) Platinum on Carbon-Catalyzed H-D Exchange Reaction of Aromatic Nuclei Due to IsopropanolMediated Self-Activation of Platinum Metal in deuterium oxide
Y. Sawama, T. Yamada, Y. Yabe, K. Morita, K. Shibata, M. Shigetsura, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 355, 1529-1534 (2013).
79) Easily-Controlled Chemoselective Hydrogenation by using Palladium on Boron Nitride
Y. Yabe, Y. Sawama, T. Yamada, S. Nagata, Y. Monguchi, H. Sajiki*
ChemCatChem, 5, 2360-2366 (2013).
80) Solvent-free Huisgen Cyclization Using Heterogeneous Copper Catalysts Supported on Chelate Resin
Y. Monguchi, K. Nozaki, T. Maejima, Y. Shimoda, Y. Sawama, Y. Kitamura, Y. Kitade, H Sajiki*
Green Chem., 15, 490-495 (2013).
81) Mechanism Study of Copper-Mediated One-Pot Reductive Amination of Aryl Halides Using
Trimethylsilyl Azide
T. Maejima, M. Ueda, J. Nakano Y. Sawama, Y. Monguchi, H. Sajiki*
J. Org. Chem., 78, 8980-8985 (2013).
82) Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon
H. Esaki, T. Hattori, A. Tsubone, S. Mibayashi, T. Sakata, Y. Sawama, Y. Monguchi, H. Yasuda, K.
Nosaka, H. Sajiki*
ChemCatChem, 5, 3629-3635 (2013).
83) Asymmetric Total Synthesis of (-)-Stenine and 9a-epi-Stenine
H. Fujioka,* K. Nakahara, N. Kotoku, Y. Ohba, Y. Nagatomi, T.-L. Wang, Y. Sawama, K. Murai, K.
Hirano, T. Oki, S. Wakamatsu, Y. Kita
Chem. Eur. J., 18, 13861-13870 (2012).
84) Effects of Phosphorus Substituents on Reactions of a-Alkoxyphosphonium Salts with Nucleophiles
A. Goto, K. Otake, O. Kubo, Y. Sawama, T. Maegawa, H. Fujioka*
Chem. Eur. J., 18, 11423-11432 (2012).
85) Reaction of acetals with various carbon nucleophiles under non-acidic conditions: C-C bond formation
via a pyridinium-type salt
H. Fujioka,* K.Yahata, T. Hamada, O. Kubo, T. Okitsu, Y. Sawama, T. Ohnaka, T. Maegawa, Y. Kita
Chem. Asian J., 7, 367-373 (2012).
986) Platinum on Carbon-Catalyzed Hydrodefluorination of Fluoroarenes Using Isopropyl Alcohol-WaterSodium Carbonate Combination
Y. Sawama, Y. Yabe, M. Shigetsura, T. Yamada, S. Nagata, Y. Fujiwara, T. Maegawa, Y. Monguchi, H.
Sajiki*Adv. Synth. Catal., 354, 777-782 (2012).
Highlighted in synfacts, 8, 0802 (2012).
87) Stereo- and Regioselective Direct Multi-Deuterium-Labeling Methods of Sugars
Y. Sawama, Y. Yabe, H. Iwata, Y. Fujiwara, Y. Monguchi, H. Sajiki*Chem. Eur. J., 18, 16436-16442 (2012).
88) Development of palladium on boron nitride catalyst and its application to semihydrogenation of alkynes
Y. Yabe, T. Yamada, S. Nagata, Y. Sawama, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 354, 1264-1268 (2012).
Highlighted in Synfacts, 8, 0001 (2012).
89) Platinum on carbon-catalyzed precise reduction control of trichloromethyl to geminal- dichloromethyl
group
T. Imanishi, Y. Fujiwara, Y. Sawama, Y. Monguchi, H. Sajiki*Adv. Synth. Catal., 354, 771-776 (2012).
Highlighted in synfacts, 8, 0684 (2012).
90) Iron-Catalyzed Chemoselective Azidation of Benzylic Silyl Ethers
Y. Sawama,* S. Nagata, Y. Yabe, K. Morita, Y. Monguchi, H. Sajiki*Chem. Eur. J., 18, 16608-16611 (2012).
91) Palladium on Carbon-Catalyzed Cross-Coupling using Triarylbismuths
Y. Monguchi, T. Hattori, Y. Miyamoto, T. Yanase, Y. Sawama, H. Sajiki*Adv. Synth. Catal., 354, 2561-2567 (2012).
92) One-pot aromatic amination based on carbon-nitrogen coupling reaction between aryl halides and azido
compounds
T. Maejima, Y. Shimoda, K. Nozaki, S. Mori, Y. Sawama, Y. Monguchi, H. Sajiki*
Tetrahedron, 68, 1712-1722 (2012).
93) Carbon-carbon bond formation by ligand-free cross-coupling reaction using palladium catalyst supported
on synthetic adsorbent
Y. Monguchi, K. Sakai, K. Endo, Y. Fujita, M. Niimura, M. Yoshimura, T. Mizusaki, Y. Sawama, H.
Sajiki*
ChemCatChem, 4, 546-558 (2012).
94) Development of Diversified Methods for Chemical Modification of the 5,6-Double Bond of Uracil
Derivatives Depending on Active Methylene Compounds
H. Sajiki,* Y. Iida, K. (Y.) Ikawa, Y. Sawama, Y. Monguchi, Y. Kitade, Y. Maki, H. Inoue, K. Hirota
Molecules, 17, 6519-6546 (2012).
95) Chemoselective hydrogenation using molecular sieves-supported Pd catalysts: Pd/MS3A and Pd/MS5A
T. Takahashi, M. Yoshimura, H. Suzuka, T. Maegawa, Y. Sawama, Y. Monguchi, H. Sajiki*10Tetrahedron, 68, 8293-8299 (2012).
96) An unusual reaction of -alkoxyphosphonium salts with Grignard reagents under an O2 atmosphere
H. Fujioka,* A. Goto, K. Otake, O. Kubo, Y. Sawama, T. Maegawa
Chem. Commun., 47, 9894-9896 (2011).
97) Reversing the Reactivity of Carbonyl Functions with Phosphonium Salts: Enantioselective Total
Synthesis of (+)-Centrolobine
H. Fujioka,* K. Yahata, O. Kubo, Y. Sawama, T. Hamada, T. Maegawa
Angew. Chem. Int. Ed., 50, 12232-12235 (2011).
98) Pyridine N-Oxide Mediated Oxidation of Diarylalkynes with Palladium on Carbon
Y. Sawama, M. Takubo, S. Mori, Y. Monguchi, H. Sajiki*
Eur. J. Org. Chem., 18, 3361-3367 (2011).
99) Combined coinage metal catalysis for the synthesis of bioactive molecules
N. Krause,* Ö. Aksin-Artok, V. Breker, C. Deutsch, B. Gockel, M. Poonoth, Y. Sawama, Y. Sawama, T.
Sun, C. WinterPure and Appl. Chem. 82, 1529-1536 (2010).
100) Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on rutheniumcatalyzed C-H bond activation
Y. Fujiwara, H. Iwata, Y. Sawama, Y. Monguchi, H. Sajiki*Chem. Commun., 46, 4977-4979 (2010).
101) Remarkable Effect of Phosphine on the Reactivity of O,P-acetal-Efficient Substitution Reaction of O,Pacetal
H. Fujioka,* A. Goto, K. Otake, O. Kubo, K. Yahata, Y. Sawama, T. Maegawa
Chem. Commun., 46, 3976-3978 (2010).
102) Regioselective Gold-Catalyzed Allylative Ring Opening of 1,4-Epoxy-1,4-dihydronaphthalenes
Y. Sawama,* K. Kawamoto, H. Satake, N. Krause, Y. Kita*
Synlett, 14, 2151-2155 (2010).
103) Pilot-plant study of the PCB degradation at ambient temperature and pressure
Y. Monguchi, S. Ishihara, A. Ido, M. Niikawa, K. Kamiya, Y. Sawama, H. Nagase, H. Sajiki*
Org. Proc. Res. Dev., 14, 1140-1146 (2010).
104) Highly Regioselective Gold-Catalyzed Ring-Opening Allylation and Azidation of Dihydrofurans
Y. Sawama, Y. Sawama, N. Krause*
Org. Lett., 11, 5034-5037 (2009).
105) Mild and efficient deprotection of acetal-type protecting groups of hydroxyl functions by triethylsilyl
triflate-2,4,6-collidine combination
H. Fujioka,* O. Kubo, K. Okamoto, K. Senami, T. Okitsu, T. Ohnaka, Y. Sawama, Y. Kita*
Heterocycles, 77, 1089-1103 (2009).
106) First Total Synthesis of (R,R,R)- and (3R,5S,9R)-Bejarol by Gold-Catalyzed Allene Cycloisomerization
and Determination of Absolute Configuration of the Natural Product11

Y. Sawama, Y. Sawama, N. Krause*
Org. Biomol. Chem., 6, 3573-3579 (2008).
107) Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase
H. Fujioka,* Y. Sawama, N. Kotoku, T. Ohnaka, T. Okitsu, N. Murata, O. Kubo, Y. Kita*
Chem. Eur. J., 13, 10225-10238 (2007).
108) Organic Chemistry Using Weakly Electrophilic Salts: Efficient Formation of O,O-Mixed, O,S- and
N,O-Acetals
H. Fujioka,* T. Okitsu, T. Ohnaka, R. Li, O. Kubo, K. Okamoto, Y. Sawama, Y. Kita*
J. Org. Chem., 72, 7898-7902 (2007).
109) Alkyl- and arylation of oxacyclic ethers with triethysilyl triflate-2,4,6-collidine-Gilman reagent
combination: remarkable discrimination of two ether oxygens
H. Fujioka,* T. Ohnaka, T. Okitsu, O. Kubo, K. Okamoto, Y. Sawama, Y. Kita*
Heterocycles, 72, 529-540 (2007).
110) Reaction of tetrahydropyranyl ethers with triethylsilyl trifluoromethanesulfonate-2,4,6-collidine
combination: speculation on the intermediate, efficient deprotection, and application to efficient ringclosing methathesis as a tether
H. Fujioka,* T. Okitsu, T. Ohnaka, Y. Sawama, O. Kubo, K. Okamoto, Y. Kita*
Adv. Synth. Catal., 349, 636-646 (2007).
111) Highly chemoselective alkylation of acetals using TESOTf-2,4,6-Collidine-Gilman reagent combination
H. Fujioka,* T. Okitsu, Y. Sawama, T. Ohnaka, Y. Kita*
Synlett, 18, 3077-3080 (2006).
112) Reaction of the Acetals with TESOTf-Base Combination; Speculation of the Intermediates and Efficient
Mixed Acetal Formation
H. Fujioka,* T. Okitsu, Y. Sawama, N. Murata, O. Kubo, R. Li, Y. Kita*
J. Am. Chem. Soc., 128, 5930-5938 (2006).
113) Unexpected and Highly Chemoselective Deprotection of the Acetals from Aldehydes and not Ketones
H. Fujioka,* Y. Sawama, N. Murata, T. Okitsu, O. Kubo, S. Matsuda, Y. Kita*
J. Am. Chem. Soc., 126, 11800-11801 (2004).
114) Asymmetric Synthesis by the Intramolecular Haloetherification Reaction of Ene Acetal: Discriminationof Prochiral Dienes in Cyclohexane Systems
H. Fujioka,* N. Kotoku, Y. Sawama, H. Kitagawa, Y. Ohba, T-l. Wang, Y. Nagatomi, Y. Kita*
Chem. Pharm. Bull., 53, 952-957 (2005).
115) The Rearrangement of 2,3-Epoxysulfonates; and Its Application to Natural Products Syntheses; Formal
Synthesis of (-)-Aphanorphine and Total Syntheses (-)--Herbertenol and (-)-Herbertenediol
Y. Kita,* J. Futamura, Y. Ohba, Y. Sawama, J. K. Ganesh, H. Fujioka
J. Org. Chem., 68, 5917-5924 (2003).
116) Kinetically Controlled Optical Resolution of Racemic Norbornene Aldehyde Derivatives
H. Fujioka,* N. Kotoku, T. Fujita, R. Inoguchi, K. Murai, Y. Nagatomi, Y. Sawama, Y. Kita*
Chirality, 15, 60-67 (2003).
12117) Concise Asymmetric Synthesis of (-)-Herbertenediol
Y. Kita,* J. Futamura, Y. Ohba, Y. Sawama, J. K. Ganesh, H. Fujioka
Tetrahedron Lett., 44, 411-413 (2003).
118) (4S,5S,6S)-6-(2,2-dimethoxy)ethyl-4,5-epoxy-6-hydroxy-2-cyclohexenone, for the Cyclohexenone Coreof Scyphostatin
H. Fujioka,* N. Kotoku, Y. Sawama, Y. Nagatomi, Y. Kita*
Tetrahedron Lett., 43, 4825-4828 (2002).
119) Remarkable Effect of Aluminum Reagents on Rearrangements of Epoxy Acylates via Stable Cation
Intermediates and Its Application to the Synthesis of (S)-(+)-Sporochnol A
Y. Kita,* A. Furukawa, J. Futamura, K. Ueda, Y. Sawama, H. Hamamoto, H. Fujioka
J. Org. Chem., 66, 8779-8786 (2001).

13

[総説]
1) 水素抽出型化学変換法の開発と応用展開
澤間善成
有機合成化学協会誌, 79, 188-196 (2021).
2) Stainless Steel Ball Milling for Hydrogen Generation and its Application for Reaction
Y. Sawama,* M. Niikawa, H. Sajiki*
J. Synth. Org. Chem., Jpn., 77, 1070-1077 (2019).
3) Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions
Y. Monguchi,* T. Ichikawa, T. Yamada, Y. Sawama, H. Sajiki*Chem. Rec., 19, 3–14 (2019).
4) New Gateways to the Platinum Group Metal-Catalyzed Direct Deuterium-Labeling Method Utilizing
Hydrogen as a Catalyst Activator
Y. Sawama,* K. Park, T. Yamada, H. Sajiki*Chem. Pharm. Bull. (Current Topics), 66, 21-28 (2018).
5) アルコールを水素源とした水中で進行する不均一系触媒的環境調和型反応の開発
澤間善成、阿久津和宏、佐治木弘尚
触媒, 59, 15-19 (2017).
6) Versatile Oxidation Methods for Organic and Inorganic Substrates Catalyzed by Platinum-Group Metals
on Carbons
Y. Sawama,* S. Asai, Y. Monguchi, H. Sajiki*Chem. Rec., 16, 261–272 (2016).
7) Synthesis of triazole, indole, and five or six-membered saturated heterocyclic compounds
Y. Monguchi,* Y. Sawama, H. Sajiki*
Heterocycles, 91, 239-264 (2015).
8) New aspect of chemoselective hydrogenation utilizing heterogeneous palladium catalysts supported bynitrogen- and oxygen-containing macromolecules
Y. Yabe, Y. Sawama, Y. Monguchi, H. Sajiki*
Catal. Sci. Technol., 4,260-271 (2014).
9) Efficient H-D exchange reactions using heterogeneous platinum-group metal on carbon-H2-D2O system
Y. Sawama, Y. Monguchi, H. Sajiki*
Synlett (account), 23, 959-972 (2012).

[著書]
1) Environment-Friendly Iron-Catalyzed Reactions
Y. Sawama
in New Horizons of Process Chemistry -Scalable Reactions and Technologies-, (Eds.; Tomioka, K.;
Shioiri, T. and Sajiki, H.), Springer Nature, 2017, 51–63.

14[その他]
1) 重水素標識有機化合物の創製と利用における化学基盤技術
澤間善成、阿久津和宏、佐治木弘尚
ファルマシア（最前線）, 56, 391-395 (2020).
2) グリーンサステイナブルな反応開発から水素社会への貢献を目指して
澤間善成
薬事日報, 2016 年 3 月 4 日3) 天然物合成に学ぶ新規反応の開発
澤間善成
化学と工業, 2014 年 4 月号 p.256-262.
4) グラフェンオキシドによる金属フリー酸化反応
澤間善成
ファルマシア（トピックス）, 2011 年 47 巻 2 号 p.155-156.

15[学会やシンポジウム等での招待講演等]
1) 2021.3.27 第 141 回日本薬学会年会（広島）
元素の力で切り拓く次世代の低分子創薬～重水素から高周期元素まで「重水素標識機能性材料の網羅的合成を目指して」
2) 2020.12.7 第 1 回 Deut-Switch シンポジウム(Virtual)「重水素原子置換生体関連物質の網羅的合成と機能性評価」
3) 2020.3.6 プロセス化学会出前講義（岐阜薬科大学）「保護基の新規活用を目指して」
4) 2020.1.17 重水素化薬剤研究会（横浜市大）「緩和な条件下での有機化合物への重水素標識化」
5) 2019.9.18 第 36 回有機合成化学セミナー（岐阜）：奨励賞受賞講演「水素抽出型化学変換法の開発と応用展開」
6) 2018.7.10 第一回重水素材料研究分科会研究会（名工大）「不均一系遷移金属ならびに有機塩基触媒を用いた重水素標識化法」
7) 2018.6.28 BIO tech 2018, 第 15 回アカデミックフォーラム（東京）「有機化合物の重水素標識法」
8) 2018.6.8 日本プロセス化学会 第２回東海地区フォーラム（名工大）「不均一系触媒的脱水素反応を基盤とした有機合成」
9) 2018.2.23 第 15 回創薬基盤化学研究若手セミナー（立命館大）「水素発生法の開発と有機反応への応用」
10) 2015.8.26 エルゼビア・ジャパン株式会社
セミナー（東京）「重水素標識化合物構築法の最新動向」

R&D Connect ライフサイエンスソリューション

11) 2015.8.6 岐阜大学主催第５回化学系若手勉強会（岐阜大）「保護基への興味」
12) 2013.1.19 第１回創薬基盤化学研究セミナー（立命館大）「鉄ーシリコンが介在する効率的有用骨格構築法の開発」
13) 2012.7.14 平成 24 年度有機合成化学協会東海支部：若手研究者のためのセミナー（静岡県
大）「天然物合成に学ぶ新規反応の開発：ヘテロ環の環開裂型官能基化ならびに官能基選択的還元」

16