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current dynamics and channel remodeling induced by sub-lethal dosing of pre- and postsynaptic neurotoxins. Although most sublethal doses of the class Ia, Ib and II/III glutamate receptor antagonists CNQX and Kynurenic acid have no significant effect onAMPA/Kainate receptor (AMPAR) activity, a number of studies have demonstrated a prolonged, reversible inhibition ofsubsequent responses to AMPA/Kainate, mediated in part by an increase in GluR2-lacking Ca(2+)-permeable AMPARs. Hence,these studies used in vivo recordings of long-lasting, early onset AMPAR responses in rat visual cortex to characterize whether
CNQX and Kynurenic acid modulate a component of normal 'tonic' AMPAR activity. Single cell recordings from single layer V
cortical neurons were performed using glass pipettes containing CNQX, Kynurenic acid or ACSF in series with a one-way
junctional extracellular recording pipette. Cells were hyperpolarized to -70 mV and AMPAR-mediated EPSPs were evoked byelectrical stimulation of the optic chiasm. CNQX (50 nM) or Kynurenic acid (50 μM) had no acute effect on the AMPAR
responses. However, following a 30 min dosing regime, a significant increase in evoked AMPAR currents was observed andmaintained following washout. Cells which received only CNQX, and not a dosing regime, exhibited a fast decay of theAMPAR response suggesting an increase in GluR2-lacking Ca(2+)-permeable AMPARs. These results suggest that sub-lethal
concentrations of CNQX and Kynurenic acid induce AMPAR remodeling.Fencing at the 2016 Summer Olympics – Men's épéeThe men's épée competition in fencing at the 2016 Summer Olympics in Rio de Janeiro took place on 11

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