Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Advanced and Comprehensive Studies on Chemical
Hazard Control 2023
ケミカルハザード対策専門家特論&
Mechanism, Assessment and Remediation ofEnvironmental Pollution 2023
環境汚染の調査と評価・修復の実践&
Animal Poisoning 動物の中毒

One Health Frontier Graduate School of Excellence&
KAMPAI project1

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Class and Course Outline
1. Aim (目的)As a result of the man’s production activities, hazards fromchemicals discharged into the environment threat human/animal
health and ecosystems. People living today's modern lifestyles of
convenience have a duty to pass safe living environments on to
future generations.
Health hazards from chemicals are often activated at the interface
between humans and animals, only manifesting themselves after
they have gradually spread. To protect our environment fromhazards and realize the One World - One Health ideal, it isimperative to detect minute changes and abnormalities at thisinterface so that appropriate preventive measures can be taken.
This course is aimed at fostering expert who can capture theessence of chemical hazards and their effects on human/animal andecosystems and exercise leadership in promoting research and education in their respective areas andcontrolling hazards with the abilities to gain an overview of problems from a global perspective, under
the concept of One Health.
人間の活動に伴い、環境中に放出される化学物質は年々増え、その有害性は、人・動物の健康や生態系を脅かしています。化学物質はヒトの現在での生活に大きな恩恵をもたらしますが、その一方で、安全な生活環境を次世代に引き継ぐ義務があります。
化学物質による健康被害は、人-(飼育)動物の生活から広がってから顕在化します。環境を危険から守り、「One World One Health」を実現するためには、この界面での変化や異常を検知し、適切な予防措置を講じることが不可欠です。
今回紹介する授業では、ケミカルハザードの本質とヒト・動物・生態系への影響を捉え、One
Health のコンセプトのもとでグローバルな視点で問題を俯瞰できる能力を養い、各専門分野においてリーダーシップを発揮できる専門家を養成することを目的としています。

2. Class Design (授業デザイン)

2

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

The course provides lecture and practical class on
Field Toxicology, Risk Management including
Environmental Toxicology, Epidemiology, Risk
Assessment, Food Safety. Our subject includes newconcept of Forensic Toxicology and Shelter
Medicine.
This course also provides methodology of chemical/ toxicological analyses such as LC/MS (Liquid
Chromatography-Mass spectrometry for drugs,
pesticides and endogenous compounds such as
hormones), GC/MS (Gas Chromatography Mass
spectrometry for environmental pollutants such as PCBs, DDTs) and ICP/MS (Inductively Coupled
Plasma Mass Spectrometry for metals, trace elements), and GIS (Geographic Information System, using
spatial or geographic data) training.
In silico analyses will also be provided on Docking Simulation and Multiple Factor Analyses ofInformation Science, which are useful for your research.
In addition, you can study on the basic sciences such as Wildlife Science, Pathology, Molecular
Toxicology, Immunotoxicology, Pharmacology.
This course provides Comprehensive Studies on Chemical Hazard Control.
本コースでは、フィールド毒性学、環境毒性学を含むリスク管理、疫学、リスク評価、食品安全について講義と実習を行います。また、法医学毒性学やシェルターメディシンの新しい概念を取り入れた授業も行います。
まさらに、薬物、農薬、ホルモンなどの内因性化合物の LC/MS（液体クロマトグラフィー質量分析）、
PCB、DDT などの環境汚染物質の GC/MS（ガスクロマトグラフィー質量分析）、ICP/MS（誘導結合プラズマ質量分析）、GIS（地理情報システム、空間または地理データを使用）トレーニングなどの化学/毒性分析の方法論を提供します。
また、研究に役立つドッキングシミュレーションや情報科学の多因子解析など、インシリコ解析も行われます。
そして、野生生物学、病理学、分子毒性学、免疫毒性学、薬理学などの基礎科学についても学ぶことができます。
当該授業は、化学物質のハザードを総合的に修学するコースです。

All graduate students can freely attend
each class of interest.
You can also take the Chemical Hazard
Control Expert certification exam once you
complete the “course” and complete all
subjects, briefly described in following
paragraph 3.
また、「コース」を修了し、次項 3 で簡単に説明するすべての科目を修了すると、次項
3Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”のケミカルハザード対策専門家認定試験を受験することができます。

3. Chemical Hazard Control Expert Certification
If you complete the course subjects, examination will be given to allow comprehensive evaluation ofprogram participants’ research and education achievements in chemical hazard-related fields andrelated abilities, including those relevant to the design of chemical hazard control measures. A subject
will be announced in advance, and participants will submit a short essay and make an oral presentationon the subject. The chemical hazard certifying committee will comprehensively evaluate these essays
and presentations to determine whether individuals have passed the examination or not.
ケミカルハザード対策専門家特論の授業コース修了者には、授業の試験とは別に、エキスパート証明のための試験を受けることができます。小論文やインタビュー(発表形式)の審査を経て、合格者には証明証が発行されます。

If you are interested in the Chemical Hazard Control class or have any questions about classes, pleasecontact us at the contact details below.
授業にご興味のある方でご質問のある方は、下記のお問い合わせ先までご連絡ください。

CONTACT
COURSE COORDINATOR

WISE OFFICEOne Health Frontier Graduate School of Excellence
Address: Kita 18, Nishi 9, Kita-ku, Sapporo 0600818, JAPAN
Phone: +81-11-706-6108
ohf@vetmed.hokudai.ac.jp

Prof. Mayumi ISHIZUKALaboratory of Toxicology, Faculty of Veterinary
Medicine, Hokkaido University
tox@vetmed.hokudai.ac.jp

4Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Course Schedule
URL for Online class: (Zoom system) Meeting No. :PW：

https://※Click on the QR code to jump to the Webex class meeting room.
KAMPAI■Mechanism, Assessment and Remediation of Environmental Pollution
Advanced and Comprehensive Studies on Chemical Hazard Control (CHCE)■CHC-I: Field Toxicology & Risk Analysis■CHC-II: Chemical Analyses■CHC-III: Basic Conservation Medicine■CHC-IV: Environmental Remediation and Diagnostic Techniques■CHC-V: GIS and satellite remote sensing■CHC-VI: Informatics
International Conservation Medicine to fostering the next generation of human resources to serve as abridge between Africa and Japan (IVCMEP)■IVCMEP: Conservation Medicine I■IVCMEP: Conservation Medicine II■IVCMEP: Interdisciplinary / Intercultural Studies (Lab Rotation)
Recurrent Education for Toxicology■Animal Poisoning and Analysis I■Animal Poisoning and Analysis II
Advanced Environmental Toxicology■Advanced Environmental Toxicology
2023

14Jul
15Jul
16Jul
17Jul

18Jul

19Jul

20Jul

8:45-10:15

10:30-12:00

13:00-14:30

14:45-16:15

16:30-18:00

OnDemandArrivalFri

Conservation
Medicine I
Conservation
Medicine I
Conservation
Medicine I
Conservation
Medicine I

Sat
Sun
Mon

Tue

Ishizuka
Guidance for
ChemicalHazard(Online &Grad room 3
#418)

Wed

Thu

IVCMEPIVCMEP pre
IVCMEP preHirose GIS(Online(partially) andNimaco &Yohannes
EnvironToxicol(Online &Grad room 3#418)
Hirose GIS(Online(partially) andGrad room 3#418)

Nimaco &Yohannes
EnvironToxicol(Online &Grad room 3#418)
Hirose GIS(Online(partially) andGrad room 3#418)

Hirose GIS(Online(partially) andGrad room 3#418)

Hirose GIS(Online(partially) andHirose GIS(Online(partially) andHirose GIS(Online(partially) andNimacoFood Safety(Online &Grad room 3
#418)

5

Isoda Risk
Analysisondemand

Uchida,Understanding
Plants and
Soils(Glo Food Res)
ondemand
Hiwatari
ImpactEvaluation of
Development

Conservation
Medicine I

Conservation
Medicine I

RemarkAdvanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

21Jul

Fri

22Jul

Sat

23Jul

Sun

24Jul

25Jul

26Jul

27Jul

Mon

Tue

Wed

Grad room 3#418)

Grad room 3#418)

Grad room 3#418)

Grad room 3#418)

HiroseGIS(Online(partially) andGrad room 3#418)

Hirose GIS(Online(partially) andGrad room 3#418)

Hirose GIS(Online(partially) andGrad room 3#418)

Hirose GIS(Online(partially) andGrad room 3
#418)

Fri

29Jul

Sat

30Jul

Sun

Conservation
Medicine I

Conservation
Medicine I
Conservation
Medicine II
TakedaDocking
Simulation(Online &Grad room 3#418)
TakedaDocking
Simulation(Online &Grad room 3#418)
Eguchi Basic&Multivariate
Analysis(Online &Grad room 3#418)

TakedaDocking
Simulation(Online &Grad room 3#418)
TakedaDocking
Simulation(Online &Grad room 3#418)
Eguchi Basic&Multivariate
Analysis(Online &Grad room 3#418)
Otsuguro
Pharmacology(Online &Grad room 3
#418)

Thu

28Jul

Program(Ecomonic)
ondemandToyoda,EnvironRadioactivity
and healthhazard(Env. Sci.)
ondemandTsubota
Wildlife
Toxicology &Ecotoxicology(Online &Grad room 3#418)

KimuraToxicol
Pathology(Online &Grad room 3#418)

TakedaDocking
Simulation(Online &Grad room 3#418)
TakedaDocking
Simulation(Online &Grad room 3#418)
Eguchi Basic&Multivariate
Analysis(Online &Grad room 3#418)
TanakaVeterinary
Forensics(Online &Grad room 3#418)

TakedaDocking
Simulation(Online &Grad room 3#418)
TakedaDocking
Simulation(Online &Grad room 3#418)
Eguchi Basic&Multivariate
Analysis(Online &Grad room 3#418)
TanakaVeterinary
Forensics(Online &Grad room 3#418)

Ohashi
ImmuneToxicol(Online &Grad room 3#418)

Ohashi
ImmuneToxicol(Online &Grad room 3#418)

Tohyama,
Health Science(Health Sci)
ondemand
Igarashi,Remediatemine sites(Eng. School)
ondemandConservation
Medicine II

Conservation
Medicine II

Conservation
Medicine II

Conservation
Medicine II

Conservation
Medicine II

Returning

31Jul

Mon

1Aug

Tue

KamiyaEnvironRemediation

KamiyaEnvironRemediation

Takahashi
RemoteSensing(Online &Grad room 3#418)
Takahashi
RemoteSensing

Takahashi
RemoteSensing(Online &Grad room 3#418)
Takahashi
RemoteSensing6

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

2Aug

Wed

3Aug

Thu

4Aug

Fri

5Aug
6Aug

(Online &Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room
3 #418)
Envision
GIS&Ecology(Grad room 3#418)(Online &Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room
3 #418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Envision
GIS&Ecology(Grad room 3#418)(Online &Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Envision
GIS&Ecology(Grad room 3#418)

Envision
GIS&Ecology(Grad room 3#418)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)

Envision
GIS&Ecology(Grad room 3#418)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)

Envision
GIS&Ecology(Grad room 3#418)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)

Envision
GIS&Ecology(Grad room 3#418)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)
Ikenaka &Nakayama,
Anal Chem &Toxicol(Prac room
#217)

Ichii
Experimental
Molecular
Toxicology(Prac room 1#202 face-toface only)

Ichii
Experimental
Molecular
Toxicology(Prac room 1#202 face-toface only)

Ichii
Experimental
Molecular
Toxicology(Prac room 1#202 face-toface only)

Ichii
Experimental
Molecular
Toxicology(Prac room 1#202 face-toface only)

Sat
Sun

7Aug

Mon

8Aug

Tue

9Aug

Wed

10Aug

Thu

11Aug
12Aug
13Aug

(Online &Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Nimako &Yared
EnvironToxicol(Grad room 3#418)
Envision
GIS&Ecology(Grad room 3
#418)

Fri
Sat
Sun

14Aug

Mon

15Aug

Tue

7

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

16Aug
17Aug
18Aug
19Aug
20Aug

Wed
Thu
Fri
Sat
Sun

21Aug

Mon

22Aug

Tue

23Aug

Wed

24Aug

Thu

25Aug

Fri

26Aug

Sat

Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)
Isoda
Rapid Risk
Assessment(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning II(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)

Isoda
Event-basedsurvey(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)
Isoda
Rapid Risk
Assessment(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning II(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)

Isoda
Event-basedsurvey(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)
Isoda
Rapid Risk
Assessment(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning II(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)

Isoda
Event-basedsurvey(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)
Isoda
Rapid Risk
Assessment(Lecture
Room#2)
Group Work,
face to faceonly
Ikenaka &Ishizuka,AnimalPoisoning II(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2#217)
Ikenaka &Ishizuka,AnimalPoisoning I(Online &Prac room 2
#217)

8

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”Grad room 2-3: Seminar Room 2-3 for Graduate (Main Building of Faculty of Veterinary
Medicine, 4F)
第 2-3 大学院演習室：獣医学研究院本館 4 階
Prac room 1-4: Practical Class Room (Main Building of Faculty of Veterinary Medicine, 2F)
第 2-4 実習室：獣医学研究院本館２階（第４実習室は E 棟）
Lec Room 1-3: Lecture Room 1-3 (Lecture Room 2 and 3 are located at the Lecture Buildingof Faculty of Veterinary Medicine, 1F.)
３講義室：第一講義室は本館１階、第２-３講義室は講義棟１階

NOTES:The location of the classroom may change depending on the circumstances. In that case, you will be notified
in advance. In addition, face-to-face classes may be replaced with online classes depending on the status
of infectious diseases. Ally course students can also participate.
状況により、教室の場所が変更になる場合があります。その場合は、事前にお知らせします。また、感染症の状況により、対面授業からオンライン授業に変更する場合があります。卓越大学院 Ally コースも同様です。
After completing the Chemical Hazard Experts course, you will have an exam of the course and if you pass,
you will receive a “certificate of completion”. If you want to participate in the “expert certification” exam
for chemical hazard control, you need to submit the application in advance.
ケミカルハザードエキスパートコース修了後、コースの試験を行い、合格すると「修了証」をお渡しします。これとは別に、ケミカルハザード対策専門家認定試験に参加する場合は、事前に申請書を提出する必要があります。
You can take part in individual classes that interest you, but the following classes may limit the number ofparticipants in order to conduct the practical training. Please note that we will recruit in advance.
興味のある授業に個別に参加することも可能ですが、以下の授業は実習を行うため、参加人数を制限する場合があります。あらかじめご了承の上、履修ください。


GIS (Geographic Information System) Basics and Practices
Analytical Chemistry / Toxicology.

The following lessons use computers, so please bring your laptop.
Docking Simulation (Chemical Hazard VI)
Multiple Factor Analysis: Basics and Practices (Chemical Hazard VI)

GIS (Geographic Information System) Basics and Practices (Chemical Hazard V, Mechanism,
Assessment and Remediation of Environmental Pollution
以下の授業はパソコンを使用しますので、ノートパソコンをご持参ください。
Docking Simulation (ケミカルハザード対策専門家特論 VI)
9Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Multiple Factor Analysis: Basics and Practices (ケミカルハザード対策専門家特論 VI)
GIS(地理情報システム)実習（ケミカルハザード対策専門家特論 V および環境汚染の調査と評価・修復の実践)

10

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Lecturers and Class Keywords 1.
Advanced and Comprehensive Studies on Chemical Hazard Control I‐V
ケミカルハザード対策専門家特論！～V
The environmental pollution problem is a global issue and efforts from various fields are necessary.
Especially veterinary medicine is a field where bridges between humans and animals, ecosystems. Under
the concept of ”One Health”, to prevent chemical hazards occurring around the world, we set up a specialist
course I-V on chemical hazard countermeasures for the purpose of human resource development.
 Course I provides class on Field Toxicology & Risk Analysis (Assessment, Management andCommunication).
 Course II provides methodology of chemical analyses such as LC/MS, GC/MS and ICP/MS.
 Course III provides Comprehensive Studies on Chemical Hazard Control.
 The Course IV is the classes on Environmental Remediation.
 Course V is a course on GIS (Geographic Information Systems) and remote sensing.
 The Course VI is on silico (computer) analyses of the data.
環境汚染問題は地球規模の問題であり、さまざまな分野からの取り組みが必要です。獣医学は人と動物、生態系をつなぐ架け橋となる分野です。この授業では、「One Health」のコンセプトのもと、世界中で発生するケミカルハザードを予防するため、人材育成を目的にケミカルハザード対策専門
コース I～V を設置しました。
 コース I では、フィールド毒性学とリスク分析（アセスメント、マネジメント、コミュニケーショ ン）
を学びます。
 コース II では、LC/MS、GC/MS、ICP/MS などの化学分析の方法論を学びます。
 コース III では、化学物質の危険有害性制御に関する総合的な研究を行います。
 コース IV は、環境修復に関する授業です。
 コース V は、GIS(地理情報システム)とリモートセンシングに関する授業です。
 コース VI は、in silico の授業で、ケミカルハザードに関する情報をコンピューターを用いて解
析します。

11

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

1) Advanced and Comprehensive Studies on Chemical Hazard Control I:
Field Toxicology & Risk Analysis
ケミカルハザード対策専門家特論 I フィールド毒性学とリスクアナリシス
In this class, students will learn about basic toxicology, environmental toxicology, risk analysis (riskassessment, risk management, and risk communication), food safety, and hygiene. As an emerging field,
you will also study about forensic veterinary medicine and shelter medicine. Participants will learn fromexperts in the field how to control hazards when they become apparent and how to respond to them.
この授業では、基礎毒性学、環境毒性学、リスク分析（リスク評価、リスク管理、リスクコミュニケーシ
ョン）、食品安全学、衛生学について学びます。また、新興分野として法医学獣医学、シェルターメデ
ィスンについても学びます。ハザードが顕在化した際のコントロール方法、ハザードへの対応方法などを、その分野の専門家から学びます。

Forensic Toxicology &Shelter Medicine
Forensic veterinary
medicine is a recently
established disciplinethat is closely related toanimal welfare. In thisclass, students will learn
the basics of shelter medicine, disasterveterinary medicine, and forensic veterinary
medicine, which have not yet become
widespread in Japan.
Aki TANAKA
Assistant Professor, Nippon Veterinary andLife Science University

Orientation &Introduction to Toxicology
The basic principle of
toxicology is that all
chemicals are toxic. In thiscourse, you will learn thebasics of toxicology, suchas how toxicity is caused
and how it is evaluated.
Mayumi ISHIZUKA
Professor, Faculty of Veterinary Medicine,
Hokkaido University

Risk Analysis
Risk analysis
consists of risk
assessment, risk
management,
and riskcommunication.
In this class, you will learn the basics of risk
analysis and what you should do as aprofessional when a hazard actually occurs.
Keywords: Event-Based- Survey, Rapid Risk
Assessment
Norikazu Isoda
Associate Professor, Research Center for
Zoonosis Control, Hokkaido University

Food Safety
Food safety is an evenmore important social
issue. In this class,students will learn what
factors can cause threats
to food safety and a wide
range of topics related tofood safety, including
chemical substances and microorganisms.
Motohiro HORIUCHI
Professor, Faculty of Veterinary Medicine,
Hokkaido University

12Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Ecotoxicology/Food Safety
Collins NIMAKO
Invitedlecturer
Ghana

Ecotoxicology
Analytical Chemistry &Toxioclogy
Yared Beyene
YOHANNES
Invited lecturer from
Ethiopia

fromWith chemical substances being released into the environment on a daily basis, environmental toxicology
and ecotoxicology are important research fields for the "One Health" concept. It is even said that there is
no longer an uncontaminated environment on earth. Students will learn the basics and applications of
how to evaluate the possible effects and toxicity of various chemical substances that we consume everyday.
日々、化学物質が環境中に放出される中、環境毒性学や生態毒性学は「One Health」を考える上で重要な研究分野となっています。もはや地球上に汚染されていない環境は存在しないとさえ言われている。私たちが日常的に摂取しているさまざまな化学物質について、その影響や毒性の可能性を評価する方法の基礎と応用を学びます。

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

2) Advanced and Comprehensive Studies on Chemical Hazard Control II:
Chemical Analyses
ケミカルハザード対策専門家特論 II

化学分析

In this class, students will learn how to analyze chemical substances. Students will learn state-of-the-art
analytical techniques such as high-performance liquid chromatography-mass spectrometry (LC-MS),
Inductively Coupled Plasma Mass Spectrometry (ICP-MS), gas chromatography-mass spectrometry (GCMS), and stable isotope mass spectrometry. Students will learn to actually analyze physiologically active
substances and environmental chemicals in a practical training format. In classroom lectures, students
study the principles of instrument analysis, how to handle and think about data, and how to perform
calculations.
この授業では、化学物質の分析方法について学びます。高速液体クロマトグラフィー質量分析計（LC-MS）、誘導結合プラズマ質量分析計（ICP-MS）、ガスクロマトグラフ質量分析計（GC-MS）、
安定同位体質量分析計などの最先端の分析技術を学びます。実習では、生理活性物質や環境化学物
質を実際に分析することを実習形式で学びます。座学では、機器の分析原理、データの扱い方・考え方、計算の仕方などを学びます。
Analytical Chemistry &Toxicology
Yoshinori Ikenaka
Associate Professor, Faculty of
Veterinary Medicine, Hokkaido
University

Analytical Chemistry &Toxioclogy
Shouta MM NAKAYAMA
Assistant Professor,
Faculty of Veterinary
Medicine, Hokkaido
University

Analytical Chemistry &Toxioclogy
Collins NIMAKO
Invited lecturer from Ghana

Analytical Chemistry &Toxioclogy
Yared Beyene
YOHANNES
Invited lecturer from
Ethiopia

In your own research, have you ever wished you could analyze chemicals...peptides...or know the amountof bioactive substances? In this class, you will learn how to analyze a wide range of chemical substances,using LC-MS, ICP-MS, GC-MS, etc.
ご自身の研究において、化学物質が分析できたら・・・ペプチドが分析できたら・・・生理活性物質の量がわかったら・・・と思われたことはありませんか？この授業では、LC-MS、ICP-MS、GC-MS などを用いて、様々な化学物質の分析方法を学びます。
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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

3) Advanced and Comprehensive Studies on Chemical Hazard Control III:
Comprehensive Studies on Chemical Hazard Control
ケミカルハザード対策専門家特論 III 保全医学基礎論
In this class, you will learn the basic knowledge required for chemical hazard control and conservation
medicine. Students will be asked to study ecology, anatomy, molecular toxicology, pharmacology,
pathotoxicology, and immunotoxicology. Most of these are taught in a lecture format, but some classes
incorporate practical exercises. The practicals will include learning about microscopy, virtual slide
technology, and patch clamping. What you learn in this class will be useful not only in chemical hazard
control, but also in many other areas of research.
この授業では、ケミカルハザード対策と保全医学に必要な基礎知識を学びます。生態学、解剖学、分子毒性学、薬理学、病理毒性学、免疫毒性学などを修学していただきます。この授業のほとんどは講義形式で行われますが、実習を取り入れた授業もあります。実習では、顕微鏡観察、バーチャルスラ
イド技術、パッチクランプなどを学びます。この授業で学んだことは、ケミカルハザード対策だけでなく、他の多くの研究分野でも役に立つことでしょう。
Wildlife Toxicology /Ecotoxicology
Conservation medicine is a
new discipline that began in
the 2000s. In this class,experts in wildlife and ecology
will lecture on the relationshipbetween human activities,
chemicals released into the environment, andwildlife.
Keyword: wildlife medicine, conservation
medicine, ecology
Toshio TSUBOTA
Professor, Faculty of Veterinary Medicine,
Hokkaido University

Experimental
Molecular
Toxicology
Students will learn
the basics ofhistologicalevaluation of theeffects of chemical substances from amolecular biological perspective.
Keyword: Effects of chemicals/drugs on organ
morpho-function
Osamu Ichii
Associate Professor, Faculty of Veterinary
Medicine, Hokkaido University

Toxicologic Pathology
Pathological analysis provides
the basic and important dataneeded to investigate
pathological conditions andtheir causes in humans andanimals. Students will learn
the basics of how histologicalimages are affected bychemicals and other factors
Keyword: pathology
Takashi Kimura
Professor, Faculty of Veterinary Medicine,
Hokkaido University

Pharmacology
Students will learn aboutpharmacology as the basis
for the effects of chemical
substances on humans andanimals.
Keyword: pharmacology
Ken‐ichi Otsuguro
Professor, Faculty of Veterinary Medicine,
Hokkaido University

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Immunotoxicology
Immunotoxicity is one of themost common effects ofchemicals, which can also
cause mass deaths directly or
indirectly. Many chemicals are
known to act on the immune
system, and this class will
cover a wide range of topics from the basics ofimmunology to immunotoxicology.
Keyword: immunology, infectious disease
Kazuhiko Ohashi
Professor, Faculty of Veterinary Medicine,
Hokkaido University

GIS and Ecotoxicology
In this class, students will practice ecology
using a variety of tools. Methods of
ecological investigation, such as satellite data
and SNS, are shifting to the use of IT tools.
We will invite researchers from NPOs thatare on the cutting edge of ecologicalresearch to conduct this class.

GIS and Ecotoxicology
In this class, students will practice ecology using
a variety of tools. Methods of ecologicalinvestigation, such as satellite data and SNS, areshifting to the use of IT tools. We will invite
researchers from NPOs that are on the cuttingedge of ecological research to conduct this class.

GIS and Ecotoxicology
In this class, students will practice ecology
using a variety of tools. Methods of
ecological investigation, such as satellite data
and SNS, are shifting to the use of IT tools.
We will invite researchers from NPOs thatare on the cutting edge of ecologicalresearch to conduct this class.

Keyword: ecology, survey, IT tool
Tsuyosi Yoshida
Researcher, ENVISION

Keyword: ecology, survey, IT tool
Keyword: ecology, survey, IT tool
Osamu Hasegawa
Researcher, ENVISION

Tomomi Kudo
Researcher, ENVISION

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

4) Advanced and Comprehensive Studies on Chemical Hazard Control IV:
Environmental Remediation
ケミカルハザード対策専門家特論 IV 環境修復
In this class, students will learn the skills and knowledge necessary for environmental restoration,
including green chemicals. Environmental remediation is taught in the form of exercises.
この授業では、グリーンケミカルをはじめとする環境修復に必要な技術や知識を学びます。環境修
復は演習形式で学びます。
Environmental Remediation
Keywords: Green Chemicals,
Environmental Remediation

New diagnostic
technologies opened
up by remote sensing
Keywords: diagnostic
technology, remotesensing

Yuichi Kamiya
Professor, Faculty ofEnvironmental Earth Science,

Yukihiro Takahashi
Professor, Space Mission Center (SMC)
Creative Research Institution (CRIS)
Hokkaido University

Hokkaido University

Environmental remediation is a technology that restores a polluted environment. In this class, students
will learn about green chemicals and other methods of environmental remediation.
環境修復とは、汚染された環境を修復する技術です。この授業では、グリーンケミカルをはじめとする環境修復の方法について学びます。

Remote sensing technology can be an important tool for various researches. In this class, experts who
have actually created and flown nano-satellites into space will teach “New diagnostic technologies
opened up by remote sensing”.
リモートセンシング技術は、様々な研究のための重要なツールとなりえます。この授業では、実際に超小型衛星を作り、宇宙に飛ばした専門家が「リモートセンシングが拓く新しい診断技術」を教えます。

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

5) Advanced and Comprehensive Studies on Chemical Hazard Control V:
GIS and satellite remote sensing
ケミカルハザード対策専門家特論 V :GIS とリモートセンシング
In this class of Chemical Hazard V, students will learn hands-on Geographic Information System (GIS) andremote sensing technology, which can be applied to various fields such as epidemiological, environmental,
ecological, and land use surveys, through lectures and practical training.
この「ケミカルハザード V」の授業では、疫学・環境・生態・土地利用調査などさまざまな分野で応用できる地理情報システム（GIS）とリモートセンシング技術を、講義と実習を通して実践的に学びます。
Basic and practices of GIS
Keyword: Geographic Information System, Satellite, Mapping
Kazuyo HIROSE
Researcher, Japan Space Systems

Now a day, GIS (Geographic Information System) and remote sensing technologies are essential for thefield research activities. Your research data can be analyzed in conjunction with the environment data,such as topography, vegetation, soil type, water environment, wildlife habitat, urban environment andhuman economic activity. Through this hands-on training for 3 days, you will learn how to acquire andanalyze GIS and satellite data.

今や GIS（地理情報システム）やリモートセンシングの技術は、フィールドでの研究活動には欠かせな
いものとなっています。地形、植生、土壌の種類、水環境、野生生物の生息地、都市環境、人間の経済活動などの環境データと連動して、実際の研究データを解析することができます。3 日間の実習を通して、GIS や衛星データの取得方法、解析方法を学びます。

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

6) Advanced and Comprehensive Studies on Chemical Hazard Control VI:
Informatics
ケミカルハザード対策専門家特論 VI :インフォマティックス
This class will be a computer-based in silico class. Students will learn how to predict and calculate how tosimulate the binding of biomolecules to chemical molecules. It will be useful for many researches because
you will learn from the assembly of protein three-dimensional structures.
Also, have you ever had trouble figuring out how to handle and analyze the large number of data obtained
from epidemiological studies, omics, and other comprehensive analyses? In this class, you will learn how
to put together diverse data such as epidemiological surveys and more than tens of thousands of omics
data such as molecular biology.
この授業は、コンピュータを使った insilico 解析の授業になります。生体分子と化学分子との結合や化学物質の動態をどのように予測し、どのようにシミュレートするかを計算する方法を学びます。
タンパク質の立体構造の組み立てから学ぶので、多くの研究に役立つでしょう。
また、疫学調査やオミックスなどの総合的な解析で得られる大量のデータをどのように扱い、解析すればよいのか困ったことはありませんか？この授業では、疫学調査などの多様なデータ、分子生物学などの数万を超えるオミックスデータをどのようにまとめるかを学びます。
Basic and Multivariate
Analysis: Basics and Practices
This course provides guidancefrom the basics to practice on
what to do when analyzinglarge amounts of factors suchas metabolomics andepidemiological studies.
Keywords: Data analysis, Data visualization,
Reproducible data analysis, R

Computational
Toxicology
Basic of MolecularDocking
Simulates affinity andinteraction between
molecules. Students will learn how to create
protein 3D structures for simulation andhow to calculate ligand affinity in docking
simulation.
Keywords: protein 3D structures, Moleculardocking, receptor, Structure prediction,
AlphaFold2, Molecular dynamics

Akifumi Eguchi
Assistant Professor, Chiba University

Kazuki Takeda
Assistant Professor, Kitasato University

19Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Lecturers and Class Keywords 2.
Mechanism, Assessment and Remediation of Environmental Pollution
環境汚染の調査と評価・修復の実践
The environmental pollution problem is a global issue and efforts from various fields are necessary.
However, effects of anthropogenic activities such as environmental pollution do not immediately catch theattention of the general public and are not easily brought under control. To resolve this global and growing
issue, contributions from various research filed are necessary, e.g., health science, social science andtechnologies for environmental remediation. In this course, professors of faculties of agriculture, veterinary
medicine, engineering, economics and business, health science and environmental earth science, andspecialist of GIS research are jointed to provide basic knowledge in each field in the omnibus classes.
※Please note that the GIS classes are scheduled far apart.
環境汚染問題は地球規模の問題であり、さまざまな分野からの取り組みが必要です。しかし、環境汚染のような人為的な活動の影響は、すぐに一般市民の目に留まるものではなく、容易にコントロール
できるものではありません。この地球規模かつ深刻な問題を解決するためには、健康科学、社会科
学、工学など、さまざまな研究分野の貢献が必要です。本講座では、農学院、獣医学院、工学院、経済経営学院、保健科学院、地球環境科学院の教授陣と GIS 研究の専門家が連携し、オムニバス形式で各分野の基礎知識を提供します。
※GIS の授業は日程が離れているのでご注意ください。
Health Science
Keyword:
HealthMaternal Healthscience,

Harukazu Tohyama
Professor, Faculty of Health
Science, Hokkaido University

Environmental Radioactivity
and health hazard: to getyour own robust gauge of therisk
Keyword: Environmental
inorganic geochemistry

Kazuhiro Toyoda
Associate Professor, Graduate School ofEnvironmental Sciences, Hokkaido University
Impact Evaluation of
Development Program
Keyword: development
economics

How do we remediate
abandoned mine sites?
Keyword: Environmental
remediation

Masato Hiwatari
Associate Professor, Faculty of
Economics and Business,
Hokkaido University

Toshifumi Igarashi
Professor, Faculty ofEngineering,
Hokkaido
University

20Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Understanding Plants andSoils ‐ in relation toenvironmental pollutions
Keyword: Introduction to Basicand environmental toxicology,
and fate of xenobiotics in our
body.
Yoshitaka Uchida
Associate Professor, Faculty of Agriculture,
Hokkaido University

Basic and practices of
GIS
Keyword: Geographic
Information System,
Satellite, Mapping
Kazuyo HIROSE
Researcher, Japan Space
Systems

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Lecturers and Class Keywords 3.
Animal Poisoning and Analysis I & II
動物の中毒 I&II
This class is a related class to the Veterinary Forensics class. Although this course is designed for working(adult) students, it can be taken by students of Hokkaido University and other universities. Students willlearn about the mechanisms of poisoning by chemical substances, methods of appraisement, andmethods of analyzing and analyzing chemical substances.
この授業は、「法獣医学」の関連授業です。社会人向けの授業ですが、もちろん、北海道大学や他大学の学生でも受講することができます。化学物質による中毒のメカニズム、鑑定方法、化学物質の分析・解析方法について学びます。
Poisoning
Mayumi ISHIZUKA
Professor, Faculty of
Veterinary Medicine,
Hokkaido University

Veterinary Forensics
Aki TANAKA
Assistant
Professor,
Nippon Veterinary andLife Science University

Analytical Chemistry &Toxioclogy
Shouta MM NAKAYAMA
Assistant Professor, Facultyof Veterinary Medicine,
Hokkaido University

Analytical Chemistry &Toxicology
Yoshinori Ikenaka
Associate Professor,
Faculty of Veterinary
Medicine, Hokkaido
University

Ecotoxicology

Ecotoxicology

Collins NIMAKO
Invited lecturer from Ghana

Yared Beyene YOHANNES
Invited lecturer from
Ethiopia

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Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

Lecturers and Class Keywords 4.
International Conservation Medicine to fostering the next
generation of human resources to serve as a bridge between Africa
and Japan (IVCMEP)
Please check Syllabus of this class.
ザンビアとの交流授業です。シラバスの詳細は WEB サイトをご覧ください。
Japanesehttps://africa.vetmed.hokudai.ac.jp/

Englushhttps://africa.vetmed.hokudai.ac.jp/en/23

Advanced and Comprehensive Studies on Chemical Hazard Control 2023
Graduate School of Veterinary Medicine &Ally Course of World-leading Innovative and Smart Education (WISE) program“One Health Frontier Graduate School of Excellence”

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