Descargar Emaksimus Full |TOP| Gratis En Esparar 1

1 info - Clicar para descargar - Pinunta La Descargar. Clicar para descargar- Pinunta La Descargar. 1. Field of the Invention The present invention
relates to novel corticotropin releasing factor (CRF) antagonists. 2.
Description of Related Art The corticotropin releasing factor (CRF) is a 41
amino acid peptide first isolated and characterized by Vale et al., Science
213:1394 (1981), and further characterized and isolated by Vale et al.,Science 213:1394-1398 (1981). The characterization of this peptide as theprimary physiological regulator of proopiomelanocortin (POMC) derived
peptide secretion provided the basis for the entire field of study on the roleof CRF and its analogs in human physiology. In a broader sense, theinvention of CRF antagonists has also been proposed for the treatment ofanxiety, depression and related illnesses in human patients. Vale et al.
demonstrated the localization of CRF in the hypothalamus of rats and statedthat CRF may play a role in the regulation of pituitary hormone release.
Further studies by Imperiale et al. (Science 217:218 (1982)) confirmed thehypothalamic localization of CRF and provided a radioimmunoassay for theidentification of human CRF. These studies also suggested that CRF is
involved in the control of smooth muscle contractility and noted acorrelation between a physiological rise in plasma CRF and fear and panic
in humans. Continued research resulted in the identification of nucleic acids
encoding the CRF peptide in the hypothalamus and brain stem of several
species, including man. The localization of CRF mRNA in the central
nervous system (CNS) and peripheral tissues further substantiated the roleof CRF as the hypothalamic release of CRF triggers pituitary hormone
secretion and ultimately results in the production and release of
adrenocorticotropic hormone (ACTH) which then produces theglucocorticoids. There is a need for compounds which function as CRF
antagonists, and which have the ability to inhibit CRF induced ACTH

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secretion. Such compounds can be useful in the diagnosis and treatment ofdiseases which are associated with dysregulation of the CRF and/orACTH/cortisol secretion pathways, such as Cushing's Syndrome,depression, anxiety, anorexia nervosa, bulimia, Alzheimer's disease,
impaired glucose tolerance,

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