1/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
Date of issue for the 1st edition : 18/Sep/2014
Date of revision : 25/Feb/2022

Safety Data Sheet

1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: 1,4-Dioxane
Reference number(SDS):33675jis_E-3
Product type：
Reagent
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
PHYSICAL AND CHEMICAL HAZARDS
Flammable liquids: Category 2
HEALTH HAZARDS
Acute toxicity (Inhalation): Category 4
Skin corrosion/irritation: Category 2
Serious eye damage/eye irritation: Category 2ACarcinogenicity: Category 1BSpecific target organ toxicity - single exposure: Category 1(central nervous system)
Specific target organ toxicity - single exposure: Category 3 (Respiratory tract irritation)
Specific target organ toxicity - single exposure: Category 3(Narcosis)
Specific target organ toxicity - repeated exposure: Category 1(kidney, liver, central nervous system)
Specific target organ toxicity - repeated exposure: Category 2(respiratory system)(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H225-Highly flammable liquid and vapor
H332-Harmful if inhaled
H315-Causes skin irritation
H319-Causes serious eye irritation
H350-May cause cancer
H370-Causes damage to organs
H335-May cause respiratory irritation
H336-May cause drowsiness or dizzinessH372-Causes damage to organs through prolonged or repeated exposure
H373-May cause damage to organs through prolonged or repeated exposure2/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
PRECAUTIONARY STATEMENT
Prevention
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
Do not breathe dust/fume/gas/mist/vapors/spray.
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
In case of fire: Use appropriate media other than water to extinguish.
Get medical advice/attention if you feel unwell.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF exposed or concerned: Call a POISON CENTER/doctor/physician.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
Storage
Store in a well-ventilated place. Keep container tightly closed. Keep cool.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.
Specific Physical and Chemical hazards
Highly flammable liquid. Vapor/air mixture may explode.

3. Composition/information on ingredients
Mixture/Substance selection:
Substance
Common name, synonyms: Diethylene dioxide
Ingredient name:1,4-Dioxane
Content (%):98.0 <Chemical formula:C4H8O2
Chemicals No, Japan:5-839
CAS No.:123-91-1
MW:88.11
ECNO:204-661-8
Stabilizing additives(EP), (GR)：2,6-Di-t-butyl-4-methylphenol(BHT)
Note : The figures shown above are not the specifications of the product.

3/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
Keep victim warm and quiet.
Call emergency medical service.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
Wash with plenty of soap and water.
If skin irritation or rash occurs: Get medical advice/attention.
If skin irritation occurs: Get medical advice/attention.
Remove and isolate contaminated clothing and shoes.
In case of burns, immediately cool affected skin for as long as possible with cｈild water.
Do not remove clothing if adhering to skin.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth. Do NOT induce vomiting.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayed(Symptoms when inhalation or ingestion)
Cough. Sore throat. Nausea. Dizziness. Headache. Drowsiness. Vomiting. Unconsciousness. Abdominal pain.
(Symptoms when skin and/or eye contact)
Conjunctival redness of the eyes Pain of the eyes.
※May be absorbed into the skin.

5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use water mist, alcohol-resistant foam, dry powder, CO2 to extinguish.
Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with full face peace operated
positive pressure mode.

4/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Keep unauthorized personnel away.
In case of contact with substance, immediately flush skin or eyes with running water for atleast 20 minutes.
Ventilate area until material pick up is complete.
Wear proper protective equipment.
PUBLIC SAFTY: Ventilate closed spaces before entering.
Do not touch or walk through spilled material.
Environmental precautions
Runoff to sewer may create fire or explosion hazard.
Vapor explosion hazard indoors, outdoors or in sewers.
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb spill with inert material (dry sand, earth, et al), then place in a chemical waste container.
Use clean non-sparking tools to collect absorbed material.
All equipment used when handling the product must be grounded.
Preventive measures for secondary accident
Collect spillage.
Stop leak if you can do it without risk.
ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
Prevent entry into waterways, sewers, basements or confined areas.
A vapor suppressing foam may be used to reduce vapors.
Keep out of low areas.

7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong acids, Oxidizing agents, Raney Nickel Catalyst should not be mixed with the chemicals.
Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.

5/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
Do not eat, drink or smoke when using this product.
Take off contaminated clothing and wash it before reuse.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed. Keep cool.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

8. Exposure controls/personal protection
Control parameters
Control value
Japan control value (1995) <= 10ppm
Adopted value
JSOH(2015) 1ppm; 3.6mg/m3 (dermal)
ACGIH(1999) TWA: 20ppm (Liver dam)
Notation…Skin
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Hand protection
Wear protective gloves. Recommended material(s): butyl rubber
Consult with your glove and/or personnel equipment manufacturer for selection of
appropriate compatible materials.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.

9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Liquid
Color: Colorless-clear
Odor: Characteristic odor
Odor threshold data is not available.
Melting point/Freezing point: 12℃
Boiling point or initial boiling point: 101℃
Boiling range data is not available.
Flammability (gases, liquids and solids): Ignitable
Lower and upper explosion limit/flammability limit:
Lower explosion limit: 2 vol %Upper explosion limit: 22.5 vol %6/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
Flash point: (c.c.)12℃
Auto-ignition temperature: 180℃
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity: 1.31mPas(20℃)
Kinematic viscosity: 1.27mm2/s(20℃)
Solubility:
Solubility in water: Miscible(100 g/100 ml )Solubility in solvent: Very soluble in ethanol and diethyl ether.
n-Octanol/water partition coefficient: log Pow-0.42
Vapor pressure: 4.1 kPa （20℃）
Vapor density data is not available.
VOC data is not available.
Evaporation rate data is not available.
Density and/or relative density: 1.03g/cm3(20℃)
Relative vapor density (Air=1): 3.0
Relative density of the Vapor/air - mixture at 20℃ (Air = 1): 1.08
Critical temperature: 312℃
Particle characteristics data is not available.

10. Stability and Reactivity
Reactivity
Reactivity data is not available.
Chemical stability
Stable under normal storage/handling conditions.
Highly flammable.
Possibility of hazardous reactions
The vapour is heavier than air and may travel along the ground; distant ignition possible.
The substance can form explosive peroxides on exposure to air.
Reacts with oxidants and strong acids.
Reacts violently with some catalysts (e.g. Raney Nickel Catalyst).
Conditions to avoid
Contact with incompatible materials.
Open flames. Heat.Sparks. Air. Light.
Incompatible materials
Strong acids, Oxidizing agents, Raney Nickel Catalyst.
Hazardous decomposition products
Carbon oxides

11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[GHS Cat. Japan, base data]
rat LD50=5170～7339 mg/kg (CERI・NITE hazard assessment data, 2006 et al.)Acute toxicity (Dermal)[GHS Cat. Japan, base data]
rat LD50=2100mg/kg (CERI・NITE risk assessment, 2006)
Acute toxicity (Inhalation)[GHS Cat. Japan, base data]
vapor: rat LC50=9158ppm/4hr (CERI/NITE Risk Assessment, 2006)

7/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
Labor standard law, Japan; Toxic
1,4-Dioxane
Irritant properties
Skin corrosion/irritation[GHS Cat. Japan, base data]
rabbit : moderate irritation (CERI・NITE risk assessment, 2006)
Serious eye damage/irritation[GHS Cat. Japan, base data]cat 2A; human/rabbit (EU-RAR No.21, 2002 et al.)Allergenic and sensitizing effects data is not available.
Germ cell mutagenicity
Reverse-mutation assay in bacteria (Ames test) :Negative(Mutagenicity Test Results for Chemicals by MHWL in Japan)
Carcinogenicity[GHS Cat. Japan, base data]
cat.1B; (MHLW carcinogenicityity examination, 1990)[IARC]
Group 2B : Possibly carcinogenic to humans[ACGIH]
A3(1999) : Confirmed Animal Carcinogen with Unknown Relevance to Humans[EPA]
L;Likely to be carcinogenic to humans(2005)[NTP]
R : Reasonably Anticipated to be Human Carcinogens[JSOH]
Group 2B: The agents which are probably or possibly carcinogenic to humans[EU]
Category 2; Substances suspected human carcinogens
Reproductive toxicity data is not available.
STOT
STOT-single exposure[cat.1][GHS Cat. Japan, base data]
central nervous system (MOE risk assessment vol.2, 2003)[cat.3 (resp. irrit.)][GHS Cat. Japan, base data]
respiratory tract irritation (ATSDR, 2007)[cat.3 (drow./dizz.)][GHS Cat. Japan, base data]narcotic effect (ATSDR, 2007)
STOT-repeated exposure[cat.1][GHS Cat. Japan, base data]
kidney; liver; central nervous system (CERI・NITE risk assessment, 2004)[cat.2][GHS Cat. Japan, base data]
respiratory system (MOE risk assessment vol.2, 2003)
Aspiration hazard data is not available.

8/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
12. Ecological Information
Ecotoxicity
Aquatic toxicity
Hazardous to the aquatic environment (Acute)[GHS Cat. Japan, base data]
Fish (Oryzias latipes) LC50 > 100mg/L/96hr(Test for the Ecological Effect of Chemicals by MOE in Japan, 1995 ,.etc.)
Water solubility
100 g/100 ml (PHYSPROP_DB, 2009)
Persistence and degradability
Persistence and degradability data is not available.
Bioaccumulative potential
log Pow=-0.27 (ICSC, 2008)
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Dispose of contents/container in accordance with local/national regulation.

14. Transport Information
UN No., UN CLASSUN No. or ID No.: 1165
UN Proper Shipping Name : DIOXANEClass or division (Transport hazard class) : 3
Packing group : II
ERG GUIDE No.: 127
IMDG Code (International Maritime Dangerous Goods Regulations)
UN No.: 1165
Proper Shipping Name : DIOXANEClass or division : 3
Packing group : II
IATA Dangerous Goods Regulations
UN No.: 1165
Proper Shipping Name : DIOXANEClass or division : 3
Hazard labels : Flamm.liquid
Packing group : II
Environmental hazards
MARPOL Annex III - Prevention of pollution by harmful substances
Marine pollutants (yes/no) : no
MARPOL Annex V - Prevention of pollution by garbage discharge
Carcinogenicity: cat.1, 1A, 1B
1,4-Dioxane
Specific target organ toxicity - repeated exposure: cat.1
1,4-Dioxane

9/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
Maritime transport in bulk according to IMO instruments
Noxious Liquid ; Cat. Y
1,4-Dioxane(Y-222)

15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
Chemicals listed in TSCA Inventory
1,4-Dioxane
Other regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by your responsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informedby supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

16. Other information
GHS classification and labelling
H225-Flam. Liq. 2: H225 Highly flammable liquid and vapor
H332-Acute Tox. 4: H332 Harmful if inhaled
H315-Skin Irrit. 2: H315 Causes skin irritation
H319-Eye Irrit. 2A: H319 Causes serious eye irritation
H350-Carc. 1B: H350 May cause cancer
H370-STOT SE 1: H370 Causes damage to organs
H335-STOT SE 3: H335 May cause respiratory irritation
H336-STOT SE 3: H336 May cause drowsiness or dizzinessH372-STOT RE 1: H372 Causes damage to organs through prolonged or repeated exposure
H373-STOT RE 2: H373 May cause damage to organs through prolonged or repeated exposure
Reference Book
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 21th edit., 2019 UN
IMDG Code, 2018 Edition (Incorporating Amendment 39-18)
IATA Dangerous Goods Regulations (62nd Edition) 2021
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2021 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192021 Recommendation on TLVs (JSOH)
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.16 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020, METI)
Definitions and Abbreviations
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)

10/10
1,4-Dioxane,JUNSEI CHEMICAL CO., LTD.,33675jis_E-3,25/Feb/2022
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)
JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of this
Safety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2020).