1CURRICULUM VITAE

CheMyong Jay Ko, PhD
Professor
College of Veterinary Medicine
University of Illinois Urbana-Champaign
Phone: 217-333-9362 (Cell: 859-494-0082)
Lab website: http://vetmed.illinois.edu/kolaboratory/
Email: jayko@illinois.edu
Research Interests: Reproductive endocrinology, development, toxicology and technology

1. PERSONAL HISTORY AND PROFESSIONAL EXPERIENCE
A. Educational Background
1986
1994
1998

BS
MS
PhD

1998-2000
2000-2002

Biology, Seoul National University, Seoul, Korea
Developmental Biology, Seoul National University, Seoul, Korea
Developmental Biology, Seoul National University, Seoul, Korea
Dissertation Topic: Body axis formation in Xenopus Laevis
Postdoctoral Scholar, Department of Physiology, University of Kentucky, Lexington, KY.
Research Topic: Progesterone receptor mediated pathway to ovulation
Postdoctoral Scholar, Department of Chemistry, University of Kentucky, Lexington, KY.
Research Topic: Regulation of folliculogenesis by FSH-receptor

B. List of Academic Positions since Final Degree
2002-2006
2006-20112011- present

Assistant Professor, Dept. of Clinical Sciences and Dept. of Biology, University of Kentucky
Associate (Endowed) Professor, Department of Clinical Sciences, University of Kentucky
Associate and Full Professor, Comparative Biosciences, College of Veterinary Medicine, University of
Illinois Urbana-Champaign

C. Other Professional Employment
1986-1989
1989-19932016-

Commanding Officer (First Lieutenant) of the 3rd ROKAF Chemical Defense Unit, Korean Air Forces(ROKAF), South Korea
Science Teacher, Gong-Hang Middle School, Seoul, Korea
Founder & CEO, Epivara (https://www.epivara.com). Develops non-surgical methods of sterilizing pet
and production animals.

D. Honors, Recognitions, and Outstanding Achievements
1983-19841990
1995-1996
1998
1998-2000
1999
2000
2001
2006
2007
2008

Alumni Fellowship, Seoul National University
The Best Research Teacher Award, Education Council, Seoul City, Korea
Seoul National University Alumni Fellowship
The Best Dissertation Award (PhD), Seoul National University
Postdoctoral Fellowship, Korea Science & Engineering Foundation
The Best Poster Award, 18th Univ. of Kentucky Symposium in Repro. Sciences
The Best Poster Award, 19th Univ. of Kentucky Symposium in Repro. Sciences
The Best Poster Award, 20th Univ. of Kentucky Symposium in Repro. Sciences
Excellence in Research Award, College of Health Sciences, University of Kentucky
Washington Research Award, University of Kentucky
Director of 27th University of Kentucky Symposium in Reproductive Sciences

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2008
2009
2010
2013
2015
2017
2020

Wethington Research Award, University of Kentucky
Wethington Research Award, University of Kentucky
Wethington Research Award, University of Kentucky
International Scientific Advisory Committee, International Conference on Endothelin
Dr. Gordon and Mrs. Helen Kruger Research Excellence Award, University of Illinois at UrbanaChampaign
Zoetis Award for Veterinary Research Excellence, University of Illinois at Urbana-Champaign
Panel member, Roundtable for Menopause by the Society for Women’s Health Research(https://swhr.org/science/roundtables/)E. Offices Held in Professional Societies
2006 - 2012
Membership Committee, Society for the Study of Reproduction2013 - Current External Research Advisory Board, International Endothelin Conference2020 - Current Development Committee, Society for the Study of Reproduction
F. Journal Editorships
2011
2011-present
2011-present
2017-present
2019-present
2023-present

Life Sciences (Guest editor)
Clinical and Experimental Reproductive Medicine
Endocrinology and Metabolism
Environmental ResearchInternational Journal of Environmental Research & Public Health
Scientific Reports

G. Review Panels
2009
20112012-2015
2012-20172013-20152012-20142015-2016
2017
2017
2018
2019
2020-

NIH CMIR Study Section, Ad-hoc member
Qatar Foundation, Qatar
CVM internal grant reviewer, University of Illinois at Urbana-Champaign
US-Israel Binational Science Foundation, Israel
Kentucky State Research Foundation
Maryland State Research Foundation
Agence Nationale de la Recherche, France
NIH ZRG1 F06 Study Section, Ad-hoc member
NIH ICER Study Section, Ad-hoc member
UIUC Graduate College Fellowship Board
NIH ZRG1 EMNR-F Study Section, Ad-hoc member
NIH CHHD-R Study Section, Standing member

2. PUBLICATIONS
A. Doctoral thesis title“Molecular studies on the Xhoxc8, Xcba-1 and Xap2 and the development of lymph heart in Xenopus laevies”
B. Chapters in Books (in print or accepted)
1. Barakat, R., Park, C. J., Perez, P. A., Chiu, K., & Ko, C. (2018). Female Antiestrogens. In M. K. Skinner (Ed.),
Encyclopedia of Reproduction. vol. 2, pp. 740–747. Academic Press: Elsevier. http://dx.doi.org/10.1016/B9780-12-801238-3.64414-8
2. Barakat, R., & Ko, C. J. (2018). Female Antiandrogens. In M. K. Skinner (Ed.), Encyclopedia of Reproduction.
vol. 2, pp. 748–752. Academic Press: Elsevier. http://dx.doi.org/10.1016/B978-0-12-801238-3.64415-X

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C. Articles in Journals (*, corresponding author)
1. Kim TK, Ko C, Nahm S, Chung HM. Partial cloning of Xhoxc3.1 gene in Xenopus laevis. Korean Journal of
Genetics 18: 111-116, 1996.
2. Ko C, Chung HM. Spatio-temporal pattern formation of abdominal muscle in Xenopus laevis. Korean Journal of
Biological Sciences 1: 329-335, 1997.
3. Kim H, Ko C, Chung HM, Kim W, Nahm S. Partial cloning and expression pattern analysis of fibroblast growth
factor-like cDNA in Xenopus oocytes. Korean Journal of Genetics 18: 51-54, 1997.
4. Ko C, In Y, Park-Sarge OK. Role of progesterone receptor activation in pituitary adenylate cyclase activating
polypeptide gene expression in rat ovary. Endocrinology 140(11): 5185-5194, 1999.
5. Ko C, Park-Sarge OK. Progesterone receptor activation mediates LH-induced type-I pituitary adenylate cyclaseactivating polypeptide receptor (PAC1) gene expression in rat granulosa cells. Biochemical Biophysical ResearchCommunications 277: 270-279, 2000.
6. Graham KM, Ko C, Park KS, Sarge K, Park-Sarge OK. Expression of an intracisternal A-particle-like element in rat
ovary. Biochemical Biophysical Research Communications 278(1): 48-57, 2000.
7. Choi I, Ko C, Park-Sarge OK, Zhou Q, Hess R, Graves C, Katzenellenbogen BS. Human estrogen receptor betaspecific antibodies: Characterization and use in studies of estrogen receptor beta protein expression in reproductive
tissues. Molecular and Cellular Endocrinology 181(1-2):1 39-150, 2001.
8. Ko C, Grieshaber NA, Ji I, Ji TH. Follicle-stimulating hormone suppresses cytosolic 3,5,3'-triiodothyronine-binding
protein messenger ribonucleic acid expression in rat granulosa cells. Endocrinology 144: 2360-2367, 2003.
9. Ko C, Chung HM. Xenopus hoxc8 during early development. Biochemical Biophysical Research Communications
12: 300(1): 9-15, 2003.
10. Grieshaber NA, Ko C, Grieshaber SS, Ji I, Ji TH. FSH-responsive cytoskeletal genes in rat granulosa cells; class I
beta-tubulin, tropomyosin-4 and kinesin heavy chain. Endocrinology 144(1): 29-39, 2003.
11. Jo M, Gieske MC, Payne CE, Gieske JB, Vijay I, Wheeler SE, Curry Jr. TE, Ko C*. Development and applicationof a rat ovarian gene expression database (rOGED). Endocrinology 145(11): 5384-5396, 2004.
12. Gieske MC, Na G, Jo M, Koo K, Curry Jr. TE, Ko C*. Decay-Accelerating Factor DAF in the periovulatory rat
ovary. Journal of Endocrinology 186: 303-313, 2005.
13. Gieske MC, Payne CE, Gieske JB, Ko C*. rOGED: NAR Molecular biology database collection entry number 739.
Nucleic Acids Research (NAR) 33: D5-D24, 2005.
14. Ko C*, Gieske MC, Al-Alem L, Hahn YK, Su W, Gong MC, Koo YB, Iglarz M. Endothelin-2 in Ovarian Follicle
Rupture. Endocrinology 147(4): 1770-1779, 2006.
15. Ko C*, Hudgins-Spivey S, Lee S, Bridges P, Gieske MC. Estrogen in female reproductive axis: Positive estrogen
feedback to pituitary. Korean Journal of Reproductive Medicine 34(4): 1-11, 2007.
16. Kim HJ, Gieske MC, Hudgins S, Kim BG, Krust A, Chambon P, Ko C*. Estrogen receptor alpha-inducedcholecystokinin type A receptor expression in the female mouse pituitary. Journal of Endocrinology 195: 393-405,
2007.
17. Al-Alem L, Bridges P, Gieske MC, Su W, Gong MC, Iglarz M, Ko C*. Endothelin-2 in oocyte transport in theoviduct. Journal of Endocrinology 193(3): 383-391, 2007.
18. Bridges PJ, Koo YB, Kang DW, Hudgins-Spivey S, Lan ZJ, Xu X, DeMayo F, Cooney A, Ko C*. Generation of
Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from theovary and testis. Genesis 46: 499-505, 2008.
19. Na G, Bridges PJ, Koo YB, Ko C*. Role of hypoxia in the regulation of periovulatory endothelin-2 (EDN2)
expression in the mouse. Canadian Journal of Physiology and Pharmacology (CJPP) 86(6):310-319, 2008
(Invited manuscript for a special edition for endothelins).

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20. Gieske MC, Kim HJ, Legan S, Koo YB, Krust A, Chambon P, Ko C*. Pituitary gonadotroph estrogen receptoralpha is necessary for fertility in females. Endocrinology 149(1): 20-27, 2008.
21. Lee S, Kang DW, Hudgins-Spivey S, Krust A, Lee EY, Koo YB, Cheon Y, Gye MC, Chambon P, Ko C*. Thecaspecific Esr1 knockout mice lose fertility prematurely. Endocrinology 150(8): 3855-62, 2009.
22. Hong SG, Kim MK, Jang G, Oh HJ, Park JE, Kang JT, Koo OJ, Kim T, Kwon MS, Koo BC, Ra JC, Kim DY, Ko
C, Lee BC. Generation of RFP transgenic dogs. Genesis 47(5): 314-22, 2009. (Cover of the issue)
23. Kim BG, Lindeman M, Bridges P, Ko C*. Gene expression profiler for DNA microarray data. Revista Colombiana
Ciencias Pecuraris 22: 12-18, 2009.
24. Oakley OR, Kim HY, El-Amouri I, Lin PC, Cho J, Bani-Ahmad M, Ko C*. Preovulatory leukocyte infiltration in
the rat ovary. Endocrinology 151(9): 4551-9, 2010. (News and Views of the Issue of the Endocrinology)
25. Bridges PJ, Jo M, Al-Alem L, Na G, Su W, Gong MC, Jeoung M, Ko C*. Production and binding of endothelin-2(EDN2) in the rat ovary: Endothelin receptor subtype A (EDNRA) mediated contraction. Reproduction, Fertility
and Development 22: 780-787, 2010.
26. El-Amouri I, Ahmad M, Tang-Feldman Y, Lin F, Ko C, Pomeroy C, Oakley O. Increased morbidity & mortality in
MCMV infected mice following allogeneic bone marrow transplant is associated with reduced surface DAF
expression. Clinical and Experimental Immunology 126: 379-391, 2010.
27. Jeoung M, Lee S, Hwang HK, Cheon YP, Jeong YK, Gye MC, Iglarz M, Ko C, Bridges PJ. Identification of a novelrole for endothelins within the oviduct. Endocrinology 151(6): 2858-67, 2010.
28. Joseph A, Shur BD, Ko C, Chambon P, Hess R. Epididymal hypo-osmolality induces abnormal sperm morphology
and function in the estrogen receptor alpha knockout mouse. Biology of Reproduction 82(5): 958-67, 2010.
29. Joseph A, Hess R, Schaeffer DJ, Ko C, Hudgins-Spivey S, Chambon P, Shur BD. Absence of estrogen receptoralpha Leads to physiological alterations in the mouse epididymis and consequent defects in sperm function. Biology
of Reproduction 82(5): 948-57, 2010.
30. Kang DW, Ihm CH, Baek JH, Park MY, Kim JH, Son HJ, Lee HK, Park MJ, Ko C*. Histo-Physiologic
characteristics of oocyte-specific ERα knockout mouse ovary. Bumsuk Journal 13: 13-23, 2010.
31. Kang DW, Son HJ, Kim JH, Lee HK, Park MJ, Ko C*. Pathologic characteristics of ovarian hemorrhagic polycyst
in estrogen receptor-alpha (ERα) knockout mice and roles of ERα in hemorrhagic polycyst. Korean Journal of
Pathology 44: 376-83, 2010.
32. Kim HJ, Gieske MC, Trudgen K, Kim BG, Jeoung J, Hudgins-Spivey S, Krust A, Chambon P, Ko C*.
Identification of estradiol/ERa-regulated genes in the pituitary. Journal of Endocrinology 210(3): 309-21, 2011.
33. Baek TH, Kim JH, Park MJ, Lee HK, Son HJ, Soon KH, Kim CN, Ko C, Kang DW. Stromal overexpression of
decay accelerating factor (Daf/CD55) correlates with poor clinical outcome in colorectal cancer patients. Korean
Journal of Pathology 45: 445-454, 2011.
34. Oakley O, Lin PC, Bridges P, Ko C*. Animal models for the study of polycystic ovarian syndrome (PCOS).
Endocrinology and Metabolism 26(3): 193-202, 2011. (Invited review)
35. Oakley O, Frazer M, Ko C*. Pituitary-ovary-splenic axis in ovulation. Trends in Endocrinology & Metabolism(TEM) 22(9): 345-52, 2011. (Invited review)
36. Choi DH, Kim EK, Kim KH, Lee KA, Kim HY, Bridges P, Ko C*. Expression pattern of endothelin systemcomponents and localization of smooth muscle cells in the human pre-ovulatory follicle. Human Reproduction 26(5): 1171-1180, 2011.
37. Bridges PJ, Cho J, Ko C*. Endothelins in regulating ovarian and oviductal function. Frontiers in Bioscience S3.
145-155, 2011. (Invited review)
38. Bridges P, Jeoung M, Kim H, Kim JH, Lee D, Ko C*, Baker D. Methodology matters: In-Vitro fertilization versus
intracytoplasmic sperm injection and embryonic gene expression. Reproductive Biomedicine Online 23(2): 23444, 2011.

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39. Bani-Ahmad M, El-Amouri I, Ko C, Lin F, Tang-Feldman Y, Oakley O. The role of decay accelerating factor in the
immunopathogenesis of cytomegalovirus infection. Clinical and Experimental Immunology 163(2): 199-2016,
2011.
40. Yamashita S, Tai P, Charron J, Ko C, Ascoli M. The Leydig cell MEK/ERK pathway is essential for maintaining afunctional population of adult Leydig cells and for male fertility. Molecular Endocrinology 25(7): 1211-22, 2011.
41. Kim MJ, Oh HJ, Park JE, Kim JE, Hong SG, Jang G, Kwon MS, Koo BC, Kim TA, Kang SK, Ko C, Lee BC.
Generation of transgenic dogs that conditionally express green fluorescent protein. Genesis 49: 472–478, 2011.
(Cover of the issue. I had interviews with major media including New York Times.)
42. Ko C*, Meidan R, Bridges P. Why two endothelins and two receptors for ovulation and luteal regulation? Life
Science. 91: 501-6, 2012. (Invited review)
43. Lee SY, Park E, Kim SC, Ahn RS, Ko C, Lee K. ERa/E2 signaling suppresses the expression of steroidogenic
enzyme genes via cross-talk with orphan nuclear receptor Nur77 in the testes. Molecular and Cellular
Endocrinology. 362 (1-2): 91-103, 2012.
44. Sánchez-Criado JE, Trudgen K, Millán Y, Blanco A, Garrido-Gracia JC, Aguilar R, Monterde J, Martín de lasMulas J, Ko C*. Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotrophes of pituitaryspecific ESR1 knockout female mice. Reproduction 143(4): 549-58, 2012.
45. Cho J, Kim H, Kang DW, Yanagisawa M, Ko C*. Endothelin B receptor is not required but necessary for finite
regulation of ovulation. Life Science 91(13-14): 613-7, 2012.
46. Bridges PJ, Jeoung M, Shim S, Park JY, Lee JE, Sapsford LA, Trudgen K, Ko C, Gye MC, Jo M. Hematopoietic
prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase. Endocrinology 153(4): 1925-35,
2012.
47. Na G, Wolfe A, Ko C, Youn H, Lee YM, Byun SJ, Jeon I, Koo YB. A low-copy-number plasmid for retrieval of
toxic genes from BACs and generation of conditional targeting constructs. Molecular Biotechnology 54(2): 504-14,
2013.
48. Sanz E, Evanoff R, Quintana A, Evans E, Miller JA, Ko C, Amieux PS, Griswold MD, McKnight GS. RiboTaganalysis of actively translated mRNAs in Sertoli and Leydig Cells in vivo. PLoS One 8(6): e66179, 2013.
49. Cacioppo J, Oh SW, Kim HY, Cho J, Lin PC, Yanagisawa M, Ko C*. Loss of function of endothelin-2 leads toreduced ovulation and CL formation. PLoS One 24;9(4): e96115, 2014.
50. Gawriluk T, Ko C, Hong X, Christenson L, Rucker III E. Beclin-1 deficiency in the murine ovary results in the
reduction of progesterone production to promote preterm labor. Proceedings of the National Academy of Science(PNAS) 111(40): E4194-203, 2014.
51. Gal A, Lin PC, Barger A, MacNeill A, Ko C*. Vaginal fold histology reduces the variability introduced by vaginal
exfoliative cytology in the classification of mouse estrous cycle stages. Toxicological Pathology 42(8):1212-20,
2014.
52. Park E, Song CH, Park JI, Ahn RS, Choi HS, Ko C, Lee K. Transforming growth factor-β1 signaling represses
testicular steroidogenesis through cross-talk with orphan nuclear receptor Nur77. PLoS One 9(8): e104812, 2014.
53. Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S. Disrupted kisspeptin signaling in GnRH
neurons leads to hypogonadotropic hypogonadism. Molecular Endocrinology 28(2): 225-238, 2014.
54. Wu S, DiVall S, Nwaopara A, Radovick S, Wondisford F, Ko C, Wolfe A. Obesity induced infertility andhyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes 63(4): 127082, 2014.
55. Lin J, Zhu J, Li X, Lan Z, Ko C, Lei Z. Expression of genomic functional estrogen receptor 1 in mouse Sertoli cells.
Reproductive Science 21(11): 1411-22, 2014.
56. Cacioppo J, Koo YB, Gal A, Ko C*. Generation and characterization of an Endothelin-2 iCre mouse. Genesis
53(2): 245-256, 2015. (Cover of the issue)

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57. Zhao Y, Gong P, Chen Y, Nwachukwu JC, Srinivasan S, Ko C, Bagchi MK, Taylor RN, Korach KS, Nettles KW,
Katzenellenbogen JA, Katzenellenbogen BS. Dual Suppression of estrogenic and inflammatory activities fortargeting of endometriosis. Science Translational Medicine 7(271): 271ra9, 2015.
58. Cacioppo J, Koo YB, Gal A, Ko C*. Generation and characterization of an estrogen receptor beta-iCre mouse.
Genesis 54(1): 38-52, 2016.
59. Mereness AL, Murphy ZC, Forrestel AC, Richards JS., Ko C. Sellix M. Conditional deletion of Bmal1 in ovarian
theca cells disrupts ovulation in female mice. Endocrinology 157(2): 913-27, 2016.
60. Cerny KL, Ribeiro RA, Jeoung M, Ko C, Bridges PJ. Estrogen receptor alpha (ESR1)-dependent regulation of themouse oviductal transcriptome. PLoS One 11(1): e0147685, 2016.
61. Gal A, Lin P, Cacioppo J, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, and Ko
C*. Loss of fertility in the absence of Pgr expression in kisspeptin neurons. PLoS One 11(7): e0159534, 2016.
62. Barakat R, Oakley O, Kim H, Jin J, Ko C*. Extra-gonadal sites of estrogen biosynthesis and function. BMB
Reports 49(9): 488-96, 2016. (Invited review)
63. Ma Y, Andrisse S, Chen Y, Childress S, Xue P, Wang Z, Jones D, Ko C, Divall S, Wu S. Androgen Receptor in the
Ovary Theca Cells Plays a Critical Role in Androgen-Induced Reproductive Dysfunction. Endocrinology 158 (1):98-108, 2016.
64. Min E, Kandel M, Ko C, Popescu G, Jung W, and Best C. Label-free, multi-scale imaging of ex-vivo mouse brain
using spatial light interference microscopy. Scientific Reports 6: 39667, 2016.
65. Han KA, Seol W, Seo H, Shin WH, Jung S, Ko C and Chung K. Leucine-rich repeat kinase 2 exacerbates neuronalcytotoxicity through phosphorylation of histone deacetylase3 and histone deacetylation. Human Molecular
Genetics. pii: ddw363, 2016.
66. Oakley O, Kim KJ, Lin P, Cacioppo JA, Barakat R, Ko C*. Estradiol synthesis in gut-associated lymphoid tissue:
leukocyte regulation by a sexually monomorphic system. Endocrinology 157(12): 4579-4587, 2016.
67. Barakat R, Lin P, Rattan S, Brehm ES, Canisso IF, Abosalum ME, Flaws J, Hess R, Ko C. Prenatal exposure to
DEHP induces premature reproductive senescence in male mice. Toxicological Sciences 156 (1): 96-108, 2017.
68. Lan ZJ, Krause MS, Redding SD, Li X, Wu GZ, Zhou HX, Bohler HC, Ko C, Cooney AJ, Zhou J, Lei ZM.
Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice.
Molecular and Cellular Endocrinology 15: 444:26-37, 2017.
69. Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogen in male Physiology. Physiological Reviews, 97(3):995-1043, 2017. (Invited review)
70. Sarah C. Baumgarten, Marah Armouti, Ko C, Stocco C. IGF1R Expression in Ovarian Granulosa Cells is Essential
for Steroidogenesis, Follicle Survival, and Fertility in Female Mice. Endocrinology 158(7): 2309-2318, 2017.
(News and Views of the Issue of the Endocrinology)
71. Cacioppo J, Lin P, Hannon P, McDougle D, Gal A, Ko C*. Granulosa cell endothelin-2 expression is fundamental
for ovulatory follicle rupture. Scientific Reports 7(1): 817, 2017.
72. Kim MJ, Oh HJ, Kim GA, Setyawan EM, Choi YB, Lee SH, Petersen-Jones SM, Ko C, Lee BC. Birth of clones ofthe first cloned dogs. Scientific Reports. 7(1):15235, 2017
73. Chan Jin Park, Guanglin Chen, Youngbum Koo, Po-Ching Lin, Haley Prohaska, Ko C*. Generation andcharacterization of estrogen receptor alpha-iCre knock-in mouse. Genesis. Nov 8 doi: 10.1002/dvg.23084. 2017
74. Lee-Thacker S, Choi Y, Taniuchi I, Takahara T, Ko C, Jo M. Core Binding Factor b expression in ovarian
granulosa cells is essential for female fertility. Endocrinology. 159(5):2094-2109. 2018.
75. Park CJ, Kim H, Jin J. Barakat R, Lin PC, Choi JM, Ko C*. Porcine intestinal lymphoid tissues synthesize
estradiol. Journal of Veterinary Science 19(4):477-482, 2018.
76. Barakat R, Lin P, Park CJ, Popescu G, Bakery HH, Abosalum ME, Abdelaleem NM, Flaws J, Ko C*. Prenatal
Exposure to DEHP Induces Neuronal Degeneration and Neurobehavioral Abnormalities in Adult Male Mice.
Toxicological Sciences 164 (2):439-452, 2018.

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77. Duffy DM*, Ko C*, Jo M*, Brannstrom M*, Curry TE Jr*. Ovulation: Parallels with inflammatory Processes.
Endocrine Reviews 40(2):369-416. 2019 (*, contributed equally) (Cover of the issue)
78. Park CJ, Barakat R, Lin PC, Ulanov A, Li Z, Lin PC, Chiu K, Zhou S, Perez P, Lee J, Flaws J, Ko C*. Sanitary
pads and diapers contain higher phthalate contents than those in common commercial plastic products.
Reproductive Toxicology 84: 114-121. 201979. Barakat R, Seymore T, Lin PC, Park CJ, Ko C*. Prenatal exposure to an environmentally relevant phthalate mixture
disrupts testicular steroidogenesis in adult male mice. Environmental Research 172:194-201. 2019.
80. Kim DH, Park HJ, Park HS, Lee JU, Ko C, Gye MC, Choi JM. Estrogen receptor alpha in T cells suppresses follicularhelper T cell responses and prevent autoimmunity. Exp. Mo. Med. 51(4): 41. 2019.
81. Park CJ, Lin PC, Zhou S, Barakat R, Bashir S, Choi JM, Cacioppo JA, Oakley OR, Duffy DM, Lydon JP, Ko
C*. Progesterone receptor serves the ovary as a trigger of ovulation and a terminator of inflammation. Cell Reports
14;31(2):107496. 2020.
82. Barakat R, Lin PC, Park CJ, Zeineldin M, Zhou S, Rattan S, Brehm E, Flaws JA, Ko C*. Germline-dependenttransmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future
generations. Scientific Reports 10(1):5705. 2020.
83. Lee-Thacker S, Jeon H. Choi Y, Taniuchi I, Takahara T, Yoneda Y, Ko C, Jo M. Core Binding Factors Are
Essential for Ovulation, Luteinization, and Female Fertility in Mice. Scientific Reports 10(1):9921. 2020.
84. Joachim E, Barakat R, Lew B, Kim KK, Ko C*, Choi H. Single Intranasal Administration of 17ß-estradiol Loaded
Gelatin Nanoparticles Confers Neuroprotection in the Post-Ischemic Brain. Nanomedicine 29:102246. 2020.
85. Hiremath DS, Priviero FBM, Webb RC, Ko C, Narayan P. Constitutive LH receptor activity impairs NO mediatedpenile smooth muscle relaxation. Reproduction 161(1): 31-41. 2021.
86. Cheon YP, Ko C, Lee KH. Assessment of Adipocyte Differentiation and Maturation-related Gene Expression in the
Epididymal Fat of Estrogen Receptor α Knockout (ERαKO) Mouse during Postnatal Development Period. Dev
Reprod 24(4):287-296. 2021.
87. Secchi C, Belli M, Harrison TH, Swift S, Ko C, Duleba AJ, Stupack D, Chang JR, Shimasaki S. Effect of theSpatial-Temporal specific Theca Cell Cyp17 overexpression on the reproductive phenotype of the novel TC17
mouse. J Trans Med 19(1):428. 2021
88. Lee Y, Rattan S, Barakat R, Inman Z, De La Torre KM, Meling DD, Monaco MH, Irudayaraj JM, Cann IK, Ko C,
Donovan SM, Flaws JA, Warner GR. Early postnata exposure to DEHP causes sex-specific disruption of gonadal
development in pigs. Reproductive Toxicology 105:53-61. 2021.
89. Soraya AL, Suzuki Y, Morimoto M, Ko C, Ikeda K, Hirata KI, Emoto N. Protective effect of endothelin-2 inepithelial cells on Bleomycin-induced pulmonary fibrosis in mice. Kobe J Med Sci 67(2):E61-E70. 2021
90. Ko C*, Cho Y, Ham E, Cacioppo JA, Park C. Endothelin 2 – a key player in ovulation and fertility. Reproduction
163(4): R71-R80. 2022.
91. Park C, Oh JE, Feng J, Cho Y, Qiao H, Ko C*. Lifetime change of oocyte pool: contributing factors focusing on
ovulatory inflammation. Clinical & Experimental Reproductive Medicine 49(1): 16-25. 2022.
92. Sun P, Wang H, Liu L. Guo K, Li X, Cao Y Ko C, Lan ZJ, Lei Z. Aberrant activation of KRAS in mouse thecainterstitial cells results in female infertility. Frontiers in Physiology 13:991719. 2022.
93. Khaw YM, Anwar S, Zhou J, Kawano T, Lin P, Otero A, Barakat R, Drnevich J, Takahashi T, Ko C*, and Inoue
M*. Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice. EMBO
Reports. 24(3):e54228. 2023
94. Park CJ, Minabe S, Hess RA, Lin PP, Zhou S, Bashir ST, Barakat R, Gal A, Ko C*. Single neonatal estrogen
implant sterilizes female animals by decreasing hypothalamic KISS1 expression. Scientific Reports 13(1):9627.
2023.
95. Barakat R, Po-Ching Lin PC, Mary Bunnell M, Ji-Eun Oh JE, Cyrus Arnieri C, Sanya Rattan S, B
Marzbanabbasabadi, Flaws JA, and Ko C*. Additive effects of prenatal DEHP exposure and maternal high-fat dieton gonadal dysfunction in male mice. Biology of Reproduction. 1-23. 2024