Chapter 7
Dementia with Lewy bodies

CQ 7-1

What are the diagnostic criteria and key points for early diagnosis of dementia
with Lewy bodies (DLB)?
AnswerFor clinical diagnosis of DLB, the revised diagnostic criteria of the DLB International Workshop are used. The
diagnostic criteria for DLB are also provided in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-5). Memory impairment may not be noticeable in the early stage of the disease. The key point for early diagnosis is
to look for the presence or absence of decline of cognitive functions other than memory (such as attention, executivefunction, and visuospatial cognition), REM sleep behavior disorder, parkinsonism, autonomic symptoms, olfactory
disturbance, depressive symptoms, and other symptoms.
In June 2017, new DLB diagnostic criteria were published.
C

Comments and evidence
In 1995, the first DLB International Workshop proposed the term “dementia with Lewy bodies” (DLB) and its clinicaldiagnostic criteria 1). The diagnostic criteria were revised at the third workshop, and further revised in 2017 2). Probable DLB(almost definite) can be diagnosed if two or more of the core features are present. In the presence of only one core clinicalfeature, probable DLB can also be diagnosed if one or more of the indicative biomarkers are present. The DSM-5 publishedin 2013 shows the diagnostic criteria for major neurocognitive disorder (dementia) with Lewy bodies and mild neurocognitive
disorder (mild cognitive impairment) with Lewy bodies 3).
In DLB, since memory impairment is often unremarkable in the early stage of the disease, it is important to examine whether
there are disorders other than memory impairment, such as attention disorder, impaired executive function, and visuospatial
impairment. Moreover, diverse clinical symptoms may manifest in addition to cognitive impairment. Paying attention to theseclinical symptoms provides important clues for early diagnosis of DLB. REM sleep behavior disorder is often seen from the
prodromal stage 4). Furthermore, studies that compared early and prodromal stages of DLB with those of Alzheimer’s disease
have reported that parkinsonism 4-6), gait disorder 6), autonomic symptoms 4, 7), olfactory dysfunction 4, 7), hallucinations 4-6),
delirium 5, 6), sleep disturbance and psychiatric symptoms 7) occur more frequently in DLB. Since many factors such as
hypersensitivity to antipsychotic drugs, syncope, and falls are directly related to poor prognosis in DLB, an accurate diagnosis
from the early stage is important for appropriate disease management.

▪ References

1) McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB):
report of the consortium on DLB international workshop. Neurology. 1996; 47: 1113-1124.
2) McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB
Consortium. Neurology. 2017; 89: 1-13.
3) American Psychiatric Association: Diagnostic and Statistical manual of Mental Disorders, Fifth edition (DSM-5). American psychiatric Publishing, 2013.
4) Boeve BF. Mild cognitive impairment associated with underlying Alzheimer’s disease versus Lewy body disease. parkinsonism and related disorders
2012; 18S1: S41-S44.
5) Jicha GA, Schmitt FA, Abner E, et al. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiology ofAging. 2010; 31: 1805-1813.
6) Auning E, Rongve A, Fladby T, et al. Early and Presenting symptoms of dementia with Lewy bodies. Dement Geriatr Cogn Disord. 2011; 32: 202-208.
7) Chiba Y, Fujishiro H Iseki E, et al, Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer’s
Disease. Dement Geriatr Cogn Disord. 2012; 33: 273-281.

▪ Search formula

PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 “Lewy Body Disease/diagnosis” [Mesh] OR ((Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (diagnosis[TI] OR diagnoses [TI] OR diagnostic [TI])) AND (“Early Diagnosis” [Mesh] OR early OR “diagnostic criteria” OR “diagnostic accuracy” OR“diagnostic classification” [TI] OR “Diagnosis, Differential” [Mesh] OR “differential diagnosis”)
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI OR Lewy body disease/TI) AND ((SH = Diagnostic use, diagnosis, diagnostic imaging, X
ray diagnosis, radionuclide diagnosis, ultrasound diagnosis)OR Diagnosis/TH OR Diagnosis/TI) AND (Early diagnosis/TH OR Early/TI OR
Diagnostic criteria/AL)

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CQ 7-2

What are the clinical and pathological differences between dementia
with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD)?
Answer(1) Lewy body disease (LBD) is a disease concept that includes all the diseases containing Lewy bodies from thepathological aspects. (2) There is no evidence that there is fundamental difference between DLB and PDD. DLB and
PDD can be viewed as a disease spectrum called LBD. (3) As an operational criterion used in research, it has been
proposed to diagnose DLB when dementia precedes parkinsonism, and PDD when parkinsonism precedes dementia for
one year or longer.

Comments and evidence

1. Terminology issue of DLB and PDD
At the first DLB International Workshop in 1995, the term DLB was proposed for dementia characterized by theneuropathological feature of the appearance of Lewy bodies with α-synuclein as the main component 1). On the other hand,
if dementia occurs after the onset of motor symptoms of Parkinson’s disease (PD), this condition has been called “Parkinson’s
disease with dementia (PDD)”. In the International Workshop, PDD is defined as cases in which parkinsonism has beenpresent for one year or longer before the onset of dementia, and DLB as cases in which the onset of dementia is before theonset of parkinsonism or within one year after onset of parkinsonism (1 year rule) 1). This one-year rule continues to be
adopted subsequently in the third workshop 2). However, note that this rule is only an operational criterion used in research.

2. Similarities and differences between DLB and PDD
A conference held in 2006 which examined the boundary issues between PDD and DLB concluded that “the differing
temporal sequence of symptoms and clinical features of PDD and DLB justify distinguishing these disorders. However, asingle Lewy body disorder model was deemed more useful for studying disease pathogenesis because abnormal neuronal
α-synuclein inclusions are the defining pathologic process common to both PDD and DLB” 3). The diagnostic criteria for
PDD have also been proposed 4).
Lewy bodies containing α-synuclein as the major component are frequently found in neurons of the brain and in autonomic
nervous system. According to the distribution pattern, Lewy body disorder is classified into the diffuse type (neocorticaltype), limbic type, brainstem type, and cerebral type (Lewy bodies are scarcely seen in the brainstem). Many patients with
LBD also have concomitant pathology of Alzheimer’s disease, and are classified into Alzheimer type, usual type, and puretype (in decremental order of concomitant Alzheimer’s pathology). Lewy body pathology spreads in different patterns,
including spread from the medulla oblongata ascending to the cerebral cortex, progression from the amygdala to cerebral
cortex or brainstem, and descending spread from the cerebral cortex to brainstem. Such pathological diversity probably
accounts for the broad spectrum of LBD phenotypes.

▪ References
1) McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB):
report of the consortium on DLB international workshop. Neurology. 1996; 47(5): 1113-1124.
2) McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology. 2005; 65(12): 1863-1872.
3) Lippa CF, Duda JE, Grossman M, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology.
2007; 68(11): 812-819.
4) Emre M, Aarsland D, Brown R, et al. Clinical diagnostic criteria for dementia associated with Parkinson disease. Mov Discord. 2007; 22(12): 16891707.

Chapter 7157▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease/diagnosis” [Mesh] OR ((Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (diagnosis[TI] OR diagnoses [TI] OR diagnostic[TI]))) AND ((“Parkinson Disease” [Mesh] AND (Dementia [Mesh] OR “Cognition Disorders” [Mesh]))OR “Parkinson’s disease dementia” OR “Parkinson disease dementia” OR PDD) OR ((“Lewy Body Disease/diagnosis” [Mesh] OR ((“Lewy body”
OR “Lewy bodies”) AND “Dementia/diagnosis”[Majr])) AND (“Parkinson Disease/diagnosis” [Mesh] OR (“Parkinson disease” AND diagnosis[TI])) AND (criteria OR “Diagnosis, Differential” [Mesh] OR “Incidence” [Mesh] OR “differential diagnosis” [TI] OR “pathologic diagnosis”))
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND (Parkinson disease/TH OR Parkinson disease/TI OR Parkinson disease/TI) AND(Dementia/TH OR Dementia/TI OR Cognitive impairment/TH OR Cognitive impairment/TI OR Cognitive function impairment/TI )158

Clinical Practice Guideline for Dementia 2017

CQ 7-3What are the characteristic laboratory and imaging biomarker of dementia
with Lewy bodies (DLB)?
AnswerDLB is characterized by reduced uptake on dopamine transporter scintigraphy and metaiodobenzylguanidine (MIBG)
myocardial scintigraphy. On CT/MRI, the medial temporal lobe is relatively preserved. Cerebral SPECT and FDG-PET
show decreased blood flow and glucose metabolism in the occipital lobe.
A

Comments and evidence
In DLB, decreased uptake is observed on 123I-MIBG myocardial scintigraphy and dopamine transporter scintigraphy. In
particular, 123I-MIBG myocardial scintigraphy is useful for differentiation from other parkinsonism-related diseases (such as
multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration) 1), while dopamine transporter
scintigraphy is highly useful for differentiation from Alzheimer’s disease 2). A report shows that a combination of 123I-MIBG
myocardial scintigraphy and dopamine transporter scintigraphy can differentiate DLB from Alzheimer’s disease dementia
with 96.1% sensitivity and 90.7% specificity 3).
When using dopamine transporter (DAT) scintigraphy in diagnosis, careful attention has to be given to the following.
(1) Differentiation between DLB and other parkinsonism-related diseases (including progressive supranuclear palsy,
multiple system atrophy, and corticobasal degeneration) is difficult because both are presynaptic disorders of nigrostriatal dopaminergic neurons.
(2) Vascular parkinsonism shows normal to mild loss in DAT uptake in the striatum. Drug-induced parkinsonism shows
normal findings, but it is necessary to confirm the history of the causative drugs use such as anti-dopaminergic agents.
(3) Tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRI), serotonin-norepinephrine reuptake inhibitors(SNRI), and other drugs (drugs with stimulant effect such as cocaine, amphetamine, methylphenidate, and modafinil)
affect the imaging result because of interaction of the ligand with drugs that have mechanisms of action on dopaminetransporters and serotonin transporters. Therefore, suspending medication or using alternative drugs should beconsidered before examination. Anti-parkinsonian drugs such as cholinesterase inhibitors, levodopa and MAOB
inhibitors have little effects on the results 4).
(4) Pregnant women and persons who are allergic to excitatory substances such as cocaine are general contraindications.
Breastfeeding is a relative contraindication 4).
(5) For patients with liver dysfunction, alcohol hypersensitivity, urinary disorder, or allergic constitution, the examination
has to be administered with caution and after obtaining consent.
The hippocampus and parahippocampal gyrus are relatively preserved on brain MRI, but brainstem atrophy may bediagnosed by statistical analysis such as Voxel-based Specific Regional Analysis System for Alzheimer’s Disease (VSRAD) 5).
On cerebral blood flow scintigraphy, both Alzheimer’s disease and DLB show decreased blood flow in the occipital lobe,
posterior cingulate gyrus, and precuneus. Whereas hippocampal blood flow is reduced in Alzheimer’s disease, it is relatively
preserved in DLB. Compared to Alzheimer’s disease, DLB is also characterized by showing earlier decreases in blood flow
and metabolism in the primary visual cortex 6). Study has shown that if the diagnosis of DLB is difficult by brain SPECT
alone, combining with 123I-MIBG myocardial scintigraphy increases the diagnostic accuracy 7).
In summary, characteristic abnormalities for DLB are found in 123I-MIBG myocardial scintigraphy, dopamine transporter
scintigraphy, MRI combined with VSRAD, and cerebral blood flow scintigraphy. When diagnosis is difficult using a single
examination, a combination of multiple examinations is expected to increase diagnostic accuracy.
Furthermore, while amyloid PET shows increased uptake in DLB similar to that in Alzheimer’s disease, cholinesterasePET (ChE-PET) is known to demonstrate decreased ChE uptake mainly in the occipital lobe in DLB 8).
Regarding cerebrospinal fluid (CSF) biomarkers, there are many reports of low CSF α-synuclein levels in DLB as in
Parkinson’s disease, but the usefulness of this marker has not been established. A report has shown that CSF levels ofphosphorylated α-synuclein and α-synuclein oligomers are elevated in DLB as in Parkinson’s disease 9). In addition, low CSF
Aβ42 level has been reported in DLB compared to controls 10).
New diagnostic criteria for DLB have been published in June 2017 (see CQ7-1). Among these criteria, the following

Chapter 7

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indicative biomarkers have been added: (1) reduced uptake in basal ganglia demonstrated by dopamine transporter
scintigraphy; (2) reduced uptake on 123I-MIBG myocardial scintigraphy; and (3) REM sleep without atonia (RWA) confirmedby polysomnography (PSG). In particular, abnormal muscle tone during REM sleep is a highly specific phenomenon forpatients with Lewy body pathology, and is recognized as an important sign even if the other biomarkers are negative.

▪ References
1) Yoshita M, et al. Diagnostic Accuracy of 123I-Meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: a multicenter
study. PLoS ONE. 2015; 10(3): e0120540.
2) McKeith I, O’Brien J, Walker Z, et al.; DLB Study Group. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECTin dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007; 6(4): 305-313.
3) Shimizu S, Hirao K, Kanetaka H, et al. Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia
with Lewy bodies from Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 20154) Japanese Society of Nuclear Medicine, Japanese Council of Nuclear Neuroimaging (Ed.) Ioflupane Clinical Practice Guidelines, First Edition. 2014;
7-8. (In Japanese)5) Nakatsuka T, Imabayashi E, Matsuda H, et al. Discrimination of dementia with Lewy bodies from Alzheimer’s disease using voxel-based
morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra.
Neuroradiology. 2013; 55(5): 559-566.
6) Fujishiro H, et al. A follow up study of non-demented patients with primary visual cortical hypometabolism: Prodromal dementia with Lewy
bodies. J Neurol Sci. 2013; 334(1-2): 48-54.
7) Hanyu H, Shimizu S, Hirao K, et al. Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing
between dementia with Lewy bodies and Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2006; 33(3): 248-253.
8) Shimada H, Hirano S, Shinotoh H, et al. Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Neurology. 2009; 73(4):273-278.
9) Zhou B, Wen M, Yu WF, et al. The diagnostic and differential diagnosis utility of cerebrospinal fluid α-synuclein levels in Parkinson’s disease: ameta-analysis. Parkinsons Dis. 2015; 2015: 567386.
10) Maetzler W, Stapf AK, Schulte C, et al. Serum and cerebrospinal fluid uric acid levels in Lewy body disorders: associations with disease occurrence
and amyloid-β pathway. J Alzheimers Dis. 2011; 27(1): 119-126.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease/diagnosis” [Mesh] OR ((Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (diagnosis[TI] OR diagnoses [TI] OR diagnostic[TI]))) AND “Diagnostic Imaging” [Mesh] OR “3-Iodobenzylguanidine/diagnostic use” [Mesh] OR“Dopamine Plasma Membrane Transport Proteins” [Mesh]) OR “magnetic resonance imaging” OR “single-photon emission computed tomography”
OR “positron emission tomography” OR DAT scan* OR neuroimaging OR MRI OR SPECT OR MIBG OR PET) OR “Lewy Body Disease/cerebrospinal fluid” [Majr] OR (“Lewy Body Disease/radionuclide imaging” [Mesh] OR ((“Lewy body” [TI] OR “Lewy bodies” [TI]) AND
dementia [TI] AND (diagnosis [TI] OR diagnoses [TI] OR diagnostic [TI]))) AND (“Fluorodeoxyglucose F18/diagnostic use” [Mesh] OR“3-Iodobenzylguanidine/diagnostic use” [Mesh] OR “Dopamine Plasma Membrane Transport Proteins/analysis” [Majr] OR Metaiodobenzylguanidine
OR meta-iodobenzylguanidine OR MIBG)
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND ((SH = Diagnostic use, diagnosis, diagnostic imaging, X ray diagnosis, radionuclide
diagnosis, ultrasound diagnosis)OR Diagnosis/TH) AND (Diagnostic imaging/TH OR “Dopamine Plasma Membrane Transport Proteins”/TH
OR DAT scan OR DAT-scan OR DAT imaging OR MRI/TI OR magnetic resonance imaging OR magnetic resonance tomography OR Magnetic
resonance imaging OR Nuclear magnetic resonance imaging OR SPECT/TI OR Single photon emission computed tomography OR Single photon
emission computed tomography OR Single photon computed tomography OR Single photon emission computed tomography OR Single photon
emission computed tomography OR Iobenguane/TH OR MIBG OR PET/TI OR Positron emission tomography)

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CQ 7-4

What are the clinical course and prognosis of dementia with Lewy bodies (DLB)?
AnswerReports have indicated that there is no difference in the progression of cognitive impairment between DLB and
Alzheimer’s disease. There are reports indicating that the time from initial consultation or diagnosis to hospital admission
or death is shorter in patients with DLB.
C

Comments and evidence
Several studies have compared the clinical course and prognosis of DLB and Alzheimer’s disease. Many of them report nodifferences between DLB and Alzheimer’s disease in terms of progression of cognitive impairment 1-6) and progression of
declined functional abilities 1, 2). The result of a recent meta-analysis also confirms no difference in the progression of cognitive
impairment 7). On the other hand, there are reports showing that the DLB group has a shorter time from the first hospital
visit to end point (admission to institutional, admission to hospital, or death) 6), and a shorter survival duration from onset
of dementia 5, 8) or from diagnosis 9). In any case, careful attention should be paid to the complications such as pneumonia,
which worsen the outcome.

▪ References
1) Stavitsky K, Brickman AM, Scarmeas N, et al. The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy
bodies and Alzheimer disease. Arch Neurol. 2006; 63(10): 1450-1456.
2) Lopez OL, Wisniewski S, Hamilton RL, et al. Predictors of progression in patients with AD and Lewy bodies. Neurology. 2000; 54(9): 1774-1779.
3) Ballard C, O’Brien J, Morris CM, et al. e progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer’s
disease. Int J Geriatr Psychiatry. 2001; 16(5): 499-503.
4) Helmes E, Bowler JV, Merskey H, et al. Rates of cognitive decline in Alzheimer’s disease and dementia with Lewy bodies. Dement Geriatr Cogn
Disord. 2003; 15(2): 67-71.
5) Williams MM, Xiong C, Morris JC, et al. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology.
2006; 67(11): 1935-1941.
6) Hanyu H, Sato T, Hirao K, et al. Differences in clinical course between dementia with Lewy bodies and Alzheimer’s disease. Eur J Neurol. 2009;16(2): 212-217.
7) Breitve MH, Chwiszczuk LJ, Hynninen MJ, et al. A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s disease.
Alzheimers Res Ther. 2014; 6(5-8): 53.
8) Matsui Y, Tanizaki Y, Arima H, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study. J Neurol
Neurosurg Psychiatry. 2009; 80(4): 366-370.
9) Stubendorff K, Hansson O, Minthon L, et al. Differences in survival between patients with dementia with Lewy bodies and patients with Alzheimer’s
disease-measured from a fixed cognitive level. Dement Geriatr Cogn Disord. 2011; 32(6): 408-416.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (“Disease Progression”[Mesh] OR “Prognosis” [Mesh] OR clinical course* OR progression OR prognosis) OR (“Lewy Body Disease” [Majr] OR ((“Lewy body” OR “Lewybodies”) AND dementia[TI])) AND (“Disease Progression” [Mesh] OR “Prognosis” [Mesh] OR clinical course* OR progression [TI] OR prognosis[TI])
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND ((SH = Prognosis)OR Prognosis/TH OR Prognosis/TI OR Natural course/AL)

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CQ 7-5

What is the treatment strategy planned for dementia with Lewy bodies (DLB)?
AnswerRegarding treatment strategy for DLB, symptomatic treatment for each of the diverse clinical symptoms is recommended.
The strategy should include pharmacotherapy and non-pharmacological therapies.
A

Comments and evidence
DLB may manifest diverse symptoms including cognitive impairment, hallucinations, delusion, depressive symptoms,
apathy, abnormal REM sleep behavior and other behavioral and psychological symptoms of dementia (BPSD), extrapyramidal
symptoms, and autonomic symptoms. Because of the diversity of symptoms, it is important to determine the major symptoms
that should be the target of treatment, and then plan the treatment strategy.
Since DLB has high risk of drug-induced adverse events, non-pharmacological interventions such as care and environmental
adaptation are particularly important. While donepezil has been used for treating cognitive impairment, symptomatic drugs
should be used for BPSD, motor deficits, and autonomic dysfunction 1).

▪ References
1) McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology. 2005; 65(12): 1863-1872.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (“Cognition
Disorders/therapy” [Mesh] OR ((cognition disorder* OR cognitive disorder*) AND (therapy OR therapeutic OR treatment))) OR (“Lewy Body
Disease/drug therapy” [Majr] OR ((“Lewy body” [TI] OR “Lewy bodies”[TI]) AND (donepezil OR rivastigmine)) OR (“Dementia/drug therapy”[Majr] AND “Parkinson Disease/ complications” [Mesh])) AND (“Cognition/drug effects” [Majr] OR ((cognitive function* OR cognitive
assessment* OR cognitive subscale*) AND improve*))
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND (Cognitive impairment/TH OR Cognitive impairment/TI OR Cognitive function
impairment/TI) AND ((SH = Therapeutic use, treatment, drug treatment, surgical treatment, transplantation, dietary treatment, psychiatrictreatment, radiologic treatment)OR Treatment/TH OR Treatment/TI OR Therapy/TI)

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CQ 7-6

Are there any drugs for the treatment of cognitive impairment in dementia
with Lewy bodies (DLB)?
Recommendation
Cholinesterase inhibitors have been reported to be effective for cognitive impairment in DLB patients.

1B

Comments and evidence
The usefulness of cholinesterase inhibitors for cognitive impairment in DLB has been reported 1). In Japan, donepezil(Aricept®) is covered by health insurance for the treatment of cognitive impairment in DLB. In a meta-analysis of randomized
controlled trials (RCT), both cholinesterase inhibitors and memantine are safe and improve Clinician’s Global Impressionof Change (CGIC), but only cholinesterase inhibitors enhance cognitive function 1). According to the results of a metaanalysis in 2015 analyzing 17 large-scale studies on Lewy body disease, cholinesterase inhibitors are useful in improving
cognitive function without worsening motor function 2).

1. Cholinesterase inhibitor (ChEI)a. Donepezil
Four open-label trials have shown the efficacy of donepezil in improving cognitive function in DLB patients. In Japan, arandomized controlled trial showed that oral donepezil at doses of 5 mg and 10 mg improved Mini Mental State Examination(MMSE) and Neuropsychiatric Inventory (NPI)-2 scores (hallucination and cognitive function) 3). Although there was no
significant difference in NPI-10 score, effectiveness was observed in change of dementia symptoms. Improvement in caregiver’s
burden was also found in the high-dose (10 mg) group. Furthermore, in a multicenter open label long-term study (52 weeks),change in cognitive function and improvement of NPI-4 score were also observed 4) [See CQ7-7 for details of the effects ofdonepezil on BPSD). Subsequently, a 56-week long-term study confirmed the tolerability and maintenance of cognitive function
improvement in patients treated with donepezil 5 mg and 10 mg 5). A placebo-controlled double-blind study (phase III) in DLB
patients demonstrated improvement in MMSE score with 10 mg, but not with 5 mg of donepezil 6).
On the other hand, a randomized controlled trial has shown the effectiveness of donepezil for cognitive function also in
PDD 7).
b. Rivastigmine
In a RCT conducted in patients with DLB, although the improvements of MMSE score and global clinical evaluation were
not significant in patients treated with oral rivastigmine, the effect of improving attention was particularly remarkable 8). A RCTof rivastigmine in patients with PDD has shown significant improvement in multiple cognitive function evaluation tests
including the Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog) 9). Regarding the efficacy on cognitive
impairment in PDD, rivastigmine was highly recommended by the European Federation of Neurological Society (EFNS)(clinical evidence class I, recommended level A) and American Academy of Neurology (AAN) (evidence level class II,
recommendation level B) 10).
c. Galantamine
A 24-week open-label study of galantamine in DLB patients showed improvement in global clinical impression and incognitive function (ADAS-cog) 11).

2. NMDA receptor antagonist: memantine
A 24-week placebo-controlled RCT of memantine in 72 DLB or PDD patients showed improvement in a cognitive
function test requiring attention (A Quick Test of Cognitive Speed; AQT) and in CGIC 12). However, the results of a metaanalysis on memantine for Lewy body disorders reported by Matsunaga et al.13) showed no significant improvement incognitive function.

Chapter 7163

▪ References
1) Wang HF, Yu JT, Tang SW, et al. Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson’s disease,
Parkinson’s disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis. J Neurol Neurosurg
Psychiatry. 2015; 86(2): 135-143.
2) Matsunaga S, Kishi T, Yasue I, Iwata N. Cholinesterase inhibitors for Lewy body disorders: a meta-analysis. Int J Neuropsychopharmacol. 2015; 28:
19(2).
3) Mori E, Ikeda M, Kosaka K. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial. Donepezil-DLB Study Investigators.
Ann Neurol. 2012; 72(1): 41-52.
4) Ikeda M, Mori E, Kosaka K, et al.; Donepezil-DLB Study Investigators. Long-term safety and efficacy of donepezil in patients with dementia with
Lewy bodies: results from a 52-week, open-label, multicenter extension study. Dement Geriatr Cogn Disord. 2013; 36(3-4): 229-241.
5) Mori E, Ikeda M, Nagai R, et al. Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial.
Alzheimers Res Ther. 2015; 7(1): 5.
6) Ikeda M, Mori E, Matsuo K, et al. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial.
Alzheimers Res Ther. 2015; 7(1): 4.
7) Dubois B, Tolosa E, Katzenschlager R, et al. Donepezil in Parkinson’s disease dementia: a randomized, double-blind efficacy and safety study. Mov
Disord. 2012; 27(10): 1230-1238.
8) McKeith I, Del Ser T, Spano P, et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlledinternational study. Lancet. 2000; 356(9247): 2031-2036.
9) Emre M, Aarsland D, Albanese A, et al. Rivastigmine for dementia associated with Parkinson’s disease. N Engl J Med. 2004; 351(24): 2509-2518.
10) Poewe W, Gauthier S, Aarsland D, et al. Diagnosis and management of Parkinson’s disease dementia. Int J Clin Pract. 2008; 62(10): 1581-1587.
11) Edwards K, Royall D, Hershey L, et al. Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study.
Dement Geriatr Cogn Disord. 2007; 23(6): 401-405.
12) Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson’s disease dementia or dementia with Lewy bodies: a double-blind,placebo-controlled, multicentre trial. Lancet Neurol. 2009; 8(7): 613-618.
13) Matsunaga S, Kishi T, Iwata N. Memantine for Lewy body disorders: systematic review and meta-analysis. Am J Geriatr Psychiatry. 2015; 23(4):373-383.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (“Cognition
Disorders/therapy” [Mesh] OR ((cognition disorder* OR cognitive disorder*) AND (therapy OR therapeutic OR treatment))) OR (“Lewy Body
Disease/drug therapy” [Majr] OR ((“Lewy body” [TI] OR “Lewy bodies” [TI]) AND (donepezil OR rivastigmine)) OR (“Dementia/drug therapy”[Majr] AND “Parkinson Disease/complications” [Mesh])) AND (“Cognition/drug effects” [Majr] OR ((cognitive function* OR cognitive
assessment* OR cognitive subscale*) AND improve*))
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease /TI) AND (Cognitive impairment/TH OR Cognitive impairment/TI OR Cognitive function
impairment/TI ) AND ((SH = Therapeutic use, treatment, drug treatment, surgical treatment, transplantation, dietary treatment, psychiatrictreatment, radiologic treatment)OR Treatment/TH OR Treatment/TI OR Therapy/TI)

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Clinical Practice Guideline for Dementia 2017

CQ 7-7

Are there any treatments for behavioral and psychological symptoms
of dementia (BPSD) and REM sleep behavior disorder (RBD) in dementia
with Lewy bodies (DLB)?
Recommendation(1) Although Yokukansan and atypical antipsychotics have been reported to be therapeutic drugs for BPSD, sufficientconsideration for safety is required. (2) The effectiveness of clonazepam for RBD has been reported. Some case reports
have indicated that Yokukansan, ramelteon, and donepezil are effective when clonazepam cannot be used.
2C

Comments and evidence
Patients with DLB may show hypersensitivity to antipsychotic drugs. Therefore, non-pharmacological interventions
should take priority over pharmacotherapy for the treatment of BPSD. Donepezil, a therapeutic drug for cognitive impairment
in DLB, may also be effective against BPSD 1).
If there is no response to the above interventions, symptomatic drugs for BPSD are used. Yokukansan has been shown tobe effective in improving NPI total score, hallucinations, delusion, depression, and anxiety symptoms 2). Although Yokukansan
does not cause extrapyramidal symptoms or anticholinergic symptoms, hypokalemia may occur occasionally which requires
attention. In addition, a report indicates the effectiveness of memantine against BPSD such as delusion, hallucinations,abnormal nocturnal behaviors, and abnormal appetite in patients with DLB 3). Antipsychotics have been used for BPSD in
DLB. However, as noted above, patients with DLB may have hypersensitivity to antipsychotics; therefore use of these drugs
requires special caution 4). Haloperidol is contraindicated for Parkinson’s disease, and should also be avoided in patients with
DLB in principle.
Among atypical antipsychotics, quetiapine and aripiprazole that have mild adverse effects on the extrapyramidal system
are considered to be relatively safe 4), but there is little evidence. Although there are reports on the effectiveness of atypicalantipsychotics for BPSD in DLB, discontinuation due to adverse effects is not uncommon. When using these drugs, it isnecessary to use the minimum dose and always pay attention to the occurrence of adverse events.
Clonazepam has been reported to be effective for the treatment for RBD. However, special attention should be paid to oversedation and falls when used in patients with DLB. Case reports have indicated that Yokukansan 5), ramelteon 6), and donepezil 7)
were effective when clonazepam cannot be used due to adverse effects. There is little evidence for the effect of clonazepam on
insomnia in DLB. In patients with DLB, attention should be paid to the effects of sleep medications causing dizziness, falls andhang-over. Two cases of insomnia in DLB responding to ramelteon have been reported 8). A report also indicates the effectivenessof Yokukansan in improving total time and efficiency of sleep, and reducing the number of arousals during sleep 9).

▪ References
1) Mori E, Ikeda M, Kosaka K, et al. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial. Ann Neurol. 2012; 72(1):41-52.
2) Iwasaki K, Kosaka K, Mori H, et al. Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administrationof yokukansan, a traditional Japanese medicine. Psychogeriatrics. 2012; 12(4): 235-241.
3) Emre M, Tsolaki M, Bonuccelli U, et al. Memantine for patients with Parkinson’s disease dementia or dementia with Lewy bodies: a randomised,double-blind, placebo-controlled trial. Lancet Neurol. 2010; 9(10): 969-977.
4) McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology. 2005; 65(12): 1863-1872.
5) Shinno H, Kamei M, Nakamura Y, et al. Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder. Prog
Neuropsychopharmacol Biol Psychiatry. 2008; 32(7): 1749-1751.
6) Nomura T, Kawase S, Watanabe Y, et al. Use of ramelteon for the treatment of secondary REM sleep behavior disorder. Intern Med. 2013; 52(18):2123-2126.
7) Ringman JM, Simmons JH. Treatment of REM sleep behavior disorder with donepezil: a report of three cases. Neurology. 2000; 55(6): 870-871.
8) Fujishiro H. Two cases of dementia with Levy body with resolution of visual hallucination by ramelteon. Japanese Journal of Geriatrics. (Nihon
Ronen Igakkai Zasshi) 2012; 49(5): 622-626. (In Japanese)9) Shinno H, Inami Y, Inagaki T, et al. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychologicalsymptoms of dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(3): 881-885.

Chapter 7165▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND ((“behavioral
psychological symptom dementia” OR BPSD) AND (therapy OR therapeutic OR treatment)) OR “Behavioral Symptoms/therapy” [Mesh] OR((“REM sleep” OR sleep disorder*) AND (therapy OR therapeutic OR treatment)) OR “Sleep Disorders/therapy”[Mesh]) OR ((((“Lewy Body
Disease/psychology” [Mesh] OR (((“Lewy body” [TI] OR “Lewy bodies” [TI]) AND dementia[TI]) AND (mental impairment* OR behaviouralsymptom* [TI]))) AND (“Lewy Body Disease/drug therapy” [Majr] OR “Delusions/drug therapy” [Majr] OR “Psychotic Disorders/drug therapy”[Majr] OR (“Dementia/drug therapy” [Majr] AND “Dementia/psychology” [Mesh]))) OR (“REM Sleep Behavior Disorder/drug therapy” [Majr]
OR (“REM Sleep Behavior Disorder/drug therapy” [Mesh] AND “REM Sleep Behavior Disorder/physiopathology”[Mesh]))) AND (“Nootropic
Agents” [Mesh] OR “Antipsychotic Agents” [Mesh] OR “Drugs, Chinese Herbal” [Mesh] OR “Dibenzothiazepines” [Mesh] OR “Anticonvulsants”[Mesh] OR “Clonazepam” [Mesh] OR “Cholinesterase Inhibitors” [Mesh]))Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND ((SH = Therapeutic use, treatment, drug treatment, surgical treatment, transplantation,
dietary treatment, psychiatric treatment, radiologic treatment)OR Treatment/TH OR Treatment/TI OR Therapy/TI) AND (Behavioral
psychological symptoms /TH OR Behavioral psychological symptoms/TI OR Behavioral symptoms /TH OR Behavioral symptoms /TI OR
Psychiatric symptoms/TH OR Psychiatric symptoms/TI OR Sleep disorder/TH OR Sleep disorder/TI)

166

Clinical Practice Guideline for Dementia 2017

CQ 7-8

Are there any treatments for autonomic symptoms (such as orthostatic
hypotension, constipation, sweating, urination disorder) in dementia
with Lewy bodies (DLB)?
Recommendation
For autonomic symptoms in DLB, drugs for the treatment of autonomic symptoms in Parkinson’s disease (PD) are usedwhile paying attention to deterioration of cognitive function and psychiatric symptoms. Non-pharmacological therapies
are also used.
2C

Comments and evidence
There are no randomized controlled trials (RCT) for autonomic symptoms in DLB, but treatments for orthostatic
hypotension, constipation, abnormal sweating, and urinary disorder are given according to those used for the treatment ofthese conditions in PD 1). In a study of 29 patients with DLB, urinary incontinence (97%) and constipation (83%) were themost common, while hypotension was found in 66%, and a history of syncope in 28% 2).
Not only orthostatic hypotension, but postprandial hypotension also occurs frequently. Especially in older patients,
dehydration is a common triggering factor, which requires attention. For the treatment of orthostatic hypotension, apartfrom non-pharmacological interventions such as salt intake, head-up tilt in bed, and wearing compressive stockings 3),
pharmacotherapy using droxidopa, midodrine, and fludrocortisone is effective.
For constipation, adequate dietary fiber and water intake, and use of laxatives such as magnesium oxide, lubiprostone,
senna, sennoside, and Daikenchuto are useful. In addition, prescribe mosapride and domperidone to improve gastrointestinal
peristalsis. In DLB, pay attention to paralytic ileus as in PD.
Regarding urinary disorder in DLB, avoid using anticholinergic drugs as far as possible because these drugs may deteriorate
cognitive function. Oxybutynin should not be used because this drug readily passes into the central nervous system and its
anticholinergic action on the central nervous system has the risk of worsening cognitive impairment 4). Paroxetine, a selective
serotonin reuptake inhibitor (SSRI), and milnacipran, a serotonin-norepinephrine reuptake inhibitor (SNRI), are sometimes
useful. Donepezil has been reported to improve attention in patients with dementia, and at the same time suppress themicturition reflex via central muscarinic M2 receptor 5). Use of the adrenoreceptor antagonists such as urapidil, tamsulosin,
and naftopidil may be considered in cases of difficulty in urination due to enlarged prostate.

▪ References
1) Low PA, Tomalia VA. Orthostatic hypotension: mechanisms, causes, management. J Clin Neurol. 2015; 11(3): 220-226.
2) Horimoto Y, Matsumoto M, Akatsu H, et al. Autonomic dysfunctions in dementia with Lewy bodies. J Neurol. 2003; 250(5): 530-533.
3) Henry R, Rowe J, O’Mahony D. Haemodynamic analysis of efficacy of compression hosiery in elderly fallers with ortho-static hypotension. Lancet.
1999; 354(9172): 45-46.
4) Orme S, Morris V, Gibson W, et al. Managing urinary incontinence in patients with dementia: pharmacological treatment options and considerations.
Drugs Aging. 2015; 32(7): 559-567.
5) Sakakibara R, Uchiyama T, Yoshiyama M, et al. Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with
Alzheimer’s disease. Neurourol Urodyn. 2005; 24(3): 273-275.

▪ Search formula

PubMed search: July 5, 2015 (Sunday), August 18, 2015 (Tuesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (“Autonomic Nervous
System Diseases/therapy” [Mesh] OR “Constipation/therapy” [Mesh] OR “Hyperhidrosis/ therapy” [Mesh] OR “Dysuria/therapy” [Mesh] OR((autonomic dysfunction* OR orthostatic hypotension* OR constipation* OR hyperhidrosis OR dysuria) AND (therapy OR therapeutic OR
treatment))) OR ((“Parkinson Disease/therapy” [Majr] OR Parkinson’s disease*) AND (((orthostatic hypotension* OR GI symptom* OR GI
complaint*) AND improve*) OR “Urination Disorders/drug therapy” [Majr] OR “Urinary Bladder Diseases/drug therapy” [Majr]))
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI OR Lewy body disease/TI) AND (Autonomic nervous system disease/TH OR Autonomic
nervous system disease/TI OR Autonomic nervous symptom/TI OR orthostatic hypotension/TI OR Constipation/TH OR Constipation/TI OR
Hyperhidrosis/TH OR Hyperhidrosis/TI OR Sweating/TI OR Urination disorder/TH OR Urination/TI)

Chapter 7

167

CQ 7-9What are the suitable treatments for parkinsonism in dementia with Lewy
bodies (DLB)?
Recommendation
Levodopa is recommended for parkinsonism in DLB patients, but high doses should be avoided because of the risk ofworsening psychiatric symptoms and involuntary movements (such as dyskinesia). Use of dopamine agonist tends toworsen psychiatric symptoms, and therefore require special caution.
2C

Comments and evidence
Although there is no randomized controlled trial (RCT) for the treatment of parkinsonism in patients with DLB​, levodopa
is recommended according to the recommendation for Parkinson’s disease (PD) 1, 2). However, response to levodopa in DLB
is generally inferior to that in PD 2). Note that high doses should not be used because there is little benefit in improving motor
symptoms, while there is a risk of exacerbating psychiatric symptoms. When levodopa is used, start from a low dose andup-titrate gradually to the minimally required dose. Anticholinergic drugs such as trihexyphenidyl have the risk of impairing
cognitive function and should be avoided in principle 2).
Using high-dose levodopa from the early stage tends to induce not only psychiatric symptoms such as hallucination, butalso motor complications such as dyskinesia and wearing-off symptoms 3),. Therefore, start from a low dose and pay attention
to whether psychiatric symptoms are worsened. Since psychiatric symptoms such as hallucination and impulse control
disorder are easily induced in patients with DLB, dopamine agonists may be used with special caution 4). In the case ofdifficulty with rolling over in bed due to wearing off symptoms at night or in early morning, rotigotine patch has beenreported to be effective for the group of diseases causing atypical parkinsonism including PD with dementia 5), but avoid
using this drug if there is any deterioration in psychiatric symptoms such as hallucination.

▪ References
1) Molloy S, McKeith IG, O’Brien JT, et al. The role of levodopa in the management of dementia with Lewy bodies. J Neurol Neurosurg Psychiatry.
2005; 76(9): 1200-1203.
2) McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology. 2005; 65(12): 1863-1872.
3) Hong JY, Oh JS, Lee I, et al. Presynaptic dopamine depletion predicts levodopa-induced dyskinesia in de novo Parkinson disease. Neurology. 2014;
82(18): 1597-1604.
4) Goldman JG, Goetz CG, Brandabur M, et al. Effects of dopaminergic medications on psychosis and motor function in dementia with Lewy bodies.
Mov Disord. 2008; 23(15): 2248-2250.
5) Moretti DV, Binetti G, Zanetti O, et al. Non-ergot dopamine agonist rotigotine as a promising therapeutic tool in atypical parkinsonism syndromes:a 24 months pilot observational open-label study. Neuropharmacology. 2014; 85: 284-289.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 19, 2015 (Wednesday)#1 (“Lewy Body Disease” [Mesh] OR Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (“Parkinsonian
Disorders/therapy” [Mesh] OR “Neurologic Manifestations/therapy” [Mesh] OR((Parkinsonian disorder* OR Parkinsonism OR dyskinesia OR
motor dysfunction*) AND (therapy OR therapeutic OR treatment))) OR (“Parkinson Disease/drug therapy” [Majr] OR ((Parkinson disease*[TIAB] OR Parkinson’s disease*[TIAB]) AND (therapy [TIAB] OR intervention* [TIAB]))) AND (“Lewy Body Disease/drug therapy” [Mesh] OR((“Lewy body” [TI] OR “Lewy bodies” [TI]) AND dementia [TI] AND (therapy [TI] OR management[TI]))OR “Dyskinesias” [Majr] ORdyskinesia* [TI])
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND ((SH = Therapeutic use, treatment, drug treatment, surgical treatment, transplantation,
dietary treatment, psychiatric treatment, radiologic treatment)OR Treatment/TH OR Treatment/TI OR Therapy/TI) AND (Parkinsonism/TH
OR Parkinsonism/TI OR Parkinson disease/TI OR Involuntary movement/TH OR Involuntary movement/TI OR Dyskinesia/TH OR Dyskinesia/
TI)

168

Clinical Practice Guideline for Dementia 2017

CQ 7-10

What are the non-pharmacological interventions for dementia with Lewy
bodies (DLB)?
AnswerNon-pharmacological interventions are also important for DLB, and appropriate care and environmental adjustment
are recommended.
D

Comments and evidence
Non-pharmacological interventions such as appropriate care and environmental improvement are also important in the
management of DLB. However, although non-pharmacological interventions may be effective in improving behavioral andpsychological symptoms of dementia (BPSD) and functional abilities in patients with DLB, there are no research reports
proving them so far. Since cognitive impairment and visual hallucination are worsened by decline in arousal and attention
levels 1), social interaction and environmental stimulation may be effective. For BPSD in DLB, using a person-centeredapproach to improve caregiver’s burden should be tried first 2). For dementia in general, removal of any trigger of agitation(pain, fear, hallucination, delusion, environment) is recommended 3). The results of a meta-analysis show that giving advice
on care to caregivers, supporting caregivers, and acquiring stress management skills are effective to reduce BPSD 4), and theseapproaches may also be useful in patients with DLB. Parkinsonism is a risk of falls in DLB patients 1, 5). Although some
reports have shown that gait rehabilitation training is useful as a non-pharmacological intervention for falls and gait
disturbances in patients with Parkinson’s disease, there is little evidence for DLB.

▪ References
1) McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.
Neurology. 2005; 65(12): 1863-1872.
2) Ballard C, Aarsland D, Francis P, et al. Neuropsychiatric symptoms in patients with dementias associated with cortical Lewy bodies: pathophysiology,
clinical features, and pharmacological management. Drugs Aging. 2013; 30(8): 603-611.
3) Boot BP, McDade EM, McGinnis SM, et al. Treatment of dementia with Lewy bodies. Curr Treat Options Neurol. 2013; 15(6): 738-764.
4) Brodaty H, Arasaratnam C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry. 2012;
169(9): 946-953.
5) Kudo Y, Imamura T, Sato A, et al. Risk factors for falls in community-dwelling patients with Alzheimer’s disease and dementia with Lewy bodies:walking with visuocognitive impairment may cause a fall. Dement Geriatr Cogn Disord. 2009; 27(2): 139-146.

▪ Search formula
PubMed search: July 5, 2015 (Sunday), August 19, 2015 (Wednesday)#1 (“Lewy Body Disease/therapy” [Mesh] OR ((Lewy body disease* OR “Lewy body dementia” OR “dementia with Lewy body”) AND (therapy
OR therapeutic OR treatment OR rehabilitation OR intervention*))) AND (“Rehabilitation” [Mesh] OR rehabilitation* OR “Psychotherapy”[Mesh] OR “Social Support” [Mesh] OR psychosocial intervention*) OR ((“Lewy Body Disease/therapy” [Mesh] OR ((“Lewy body” [TI] OR“Lewy bodies” [TI]) AND dementia [TI] AND (therapy [TI] OR management [TI]))) AND (specific intervention* OR nonpharmacologic OR
cognitive-behavioral intervention*)) OR (“Dementia/therapy” [Majr] AND “Phototherapy” [Mesh])
Ichushi search: July 6, 2015 (Monday)#1 (Lewy body disease/TH OR Lewy body disease/TI) AND ((SH = Rehabilitation)OR Rehabilitation/TH OR Rehabilitation/TI OR Psychologicaltherapy/TH OR Psychological therapy/TI OR Psychotherapy/TI OR Psychosocial therapy/TI OR Psychosocial intervention/TI OR Social support/
TH OR Social support/TI)

Chapter 7169