The 2006 Nagoya Workshop on UK –Japan Animal Biotechnology Partnershipand Internship
March 6-7, 2006
Sakae Mulberry Hotel, Nagoya, Japan

March 6 (Monday)
6 pm – 8 pm

Reception

March 7 (Tuesday)
9 am – 6 pm

Lectures, Reports and Discussion

Part I:
Animal biotechnology from the basics toapplication
Part II:
Student reports on training in UK and panel
discussion
Supported by MEXT internshipproject and Nagoya University

The peaceful rustic scenery shown on the front cover represents a distantpicturesque view of the Hannah Research Park, Ayrshire, Scotland, UK. A building ofthe Hannah Research Institute stands across a meadow. The photograph was taken byMiss Chiharu Yorikawa during her internship program in the early autumn of 2005.
Ayrshire is the birthplace of Robert Burns, a famous Scottish poet in the 18th century.
The melodies of his songs are popular among the Japanese. For example,“Hotaru-no-hikari” and “Kokyo-no-sora” were originally derived from “Auld LangSyne” and “Comin Thro' The Rye”, respectively. Alexander Fleming, who discovered
lysozyme and penicillin in the first half of the 20th century at St. Mary’s Hospital inLondon, was born and brought up in this district in Scotland. (by M. Maki, PhD)

Preface
With financial assistance from the 2004 (academic year) budget of the President’s Officeof Nagoya University, we were able to successfully organize a workshop entitled “Hannah
Research Institute (HRI) and Nagoya University (NU) Joint-Workshop on Animal Biotechnology”
held on March 2-3, 2005 at Sakae Mulberry Hotel. At this workshop, four researchers from HRI
and ten professors from Nagoya University, Mie University and Shinshu University gave
overviews of their research for the purpose of promoting mutual understanding and initiatinginternational collaborations. Students of the Graduate School of Bioagricultural Sciences of NU
made up most of the audience and they expressed interest in being involved in similar activities forpromoting cooperation in the future. Since we were fortunate enough to receive funding fromanother budget allocation of the same category for the academic year of 2005, we attempted tosend several graduate students to HRI and Hannah InterActions Ltd. to let them carry out
experiments under the supervision of researchers affiliated to HRI and NU, respectively. Becauseof the limited budget, however, we were only able to send two PhD students for one month.
Despite the possibility of expanding such interaction by funding the visits of professors from NU,Mie University and Shinsu University to Cardiff University, Roslin Institute and HRI, respectively,
the budget proved to be too small.

In order to assist those in the situation that we faced with our tight budget, we werelooking for another funding. Meanwhile we knew that the Ministry of Education, Culture, Sports,
Science and Technology of Japan (MEXT) will commence a program of sending students toresearch units of companies to promote a new type of education based on cooperation between
academia and industry at the graduate school level of Japanese universities. Based on our past
activities, we applied for this program by applying for placement of graduate students in UK
companies (or research organizations) in the field of animal biotechnology. Our proposal wasfortunately one of twenty proposals approved by MEXT and funding of ten million yen per year
was promised for the next five years. Our proposal was unique in that one of its goals is forgraduate students to gain PhD degrees under international supervision.

In order to put this program in a wider perspective, Professor Masatoshi Maki visited theUniversity of Nottingham and Cardiff University in addition to HRI and he found manylaboratories working on research projects in close interaction with companies. Many professors at
both universities expressed interest in accepting our students. Several were kind enough to accept
our invitation to come to Nagoya to explain their research to our graduate students and theiradvisers at a workshop. As summarized in this report book, four professors each from UK andJapan gave introductory lectures and we also enjoyed discussions on student placement undercommon scientific and technological interests.

We hope that many students were inspired by their lectures and will be ambitious
enough to join this student placement program.

March 2006

Yasuo Kitagawa, PhD
Professor
Graduate School of Bioagricultural Sciences
Nagoya University

The 2006 Nagoya Workshop on UK –Japan Animal Biotechnology Partnershipand Internship
March 6-7, 2006
Sakae Mulberry Hotel, Nagoya, Japan

Opening Up of New Career Paths for Graduate Students
through Placement in International R & D Activities

This workshop was organized by project members of the Educational and Research
Collaborative Internship Program in Animal Biotechnology, Graduate School of
Bioagricultural Sciences, Nagoya University and supported by MEXT internship project
and Nagoya University.

Venue: Sakae Mulberry Hotel
3-12-13, Nishiki, Naka-ku, Nagoya 460-0003
TEL(052)954-0081 FAX(052)954-0084(in Japanese) http://www.mulberryhotel.com/sakae/index.html(in English) http://www.mulberryhotel.com/english/
Contact information: M. Maki, PhD(e-mail: mmaki@agr.nagoya-u.ac.jp).

Program
March 6

17:30-18:00
18:00-20:00

March 79:00-9:15

Registration(3rd Floor)
Free Discussion(Room Take, 3rd Floor)

Registration (Room Botan, 2nd Floor)

9:15

Opening remark
Masatoshi Maki (Nagoya Univ.)
Part I: Animal biotechnology from the basics to application
Session 1(9:20- 10:30)

Chairperson: Kiyotaka Hitomi (Nagoya Univ.)
9:20

Ronald. G. Bardsley (Univ. Nottingham)
A biotechnological approach to muscle growth and meat quality in livestockat Nottingham

10:00

Jiro Takano (RIKEN, Japan)
Gene manipulation of calpain-calpastatin system in mouse

Coffee break (10:30-10:45)
Session 2(10:45-11:55)

Chairperson: Naohito Aoki (Mie Univ.)
10:45 Charles W. Archer (Cardiff Univ., UK)
Connective Tissue Stem Cells - potential in Orthopaedic Repair
11:25

Yasuo Kitagawa (Nagoya Univ.)
Human adipose-derived stem cellsLunch(11:55-13:20) Restaurant (1st Floor)
Conference room is closed and locked for security reason.

Session 3(13:20-14:40)

Chairperson: Hiroaki Oda (Nagoya Univ.)
13:20 Nicholas J. Lench (Wales Gene Park / Cardiff Univ., UK)
The Wales Gene Park – Development and characterisation of mouse models of humandisease; a route to effective translational research
14:00 Vladimir L. Buchman, (Cardiff Univ., UK)
Studies of molecular mechanisms of synucleinopathies using transgenic mouse models

Coffee break
Session 4(14:40-14:55)(14:55-15:55)

Chairperson: Hiroshi Kagami (Shinshu Univ.)
14:55

Shin-Ichiro Takahashi (Univ. Tokyo)
The novel mechanisms for the modulation of insulin/IGF signals

15:25 Tetsuya Okajima (Nagoya Univ)
Control of Notch receptor function and structure by glycosyltransferases
Coffee break(15:55-16:10)

Part II: Student reports on training in UK and panel discussion
Chairperson: Masatoshi Maki (Nagoya Univ.)
16:10

Chiharu Yorikawa (Nagoya Univ.)
Student report 1: The Hannah Research Institute (Ayr, UK)

16:30 Fumitaka Ichioka (Nagoya Univ.)
Student report 2: The Wales Gene Park / Cardiff Univ. (Cardiff, UK)
17:00 Panel discussion
Masatoshi Maki (Nagoya Univ.)
Keynote report: Educational and research collaborative internship program for PhD course
students from a worldwide perspective
Ronald. G. Bardsley (Univ. Nottingham, UK)
Exchange and Cooperative Programmes in the University of Nottingham School ofBiosciences
Charles W. Archer (Cardiff Univ., UK)
Postgraduate research opportunities in Cardiff School of Biosciences
Yasuo Kitagawa (Nagoya Univ.)
Candidates of UK companies for training graduate students in FY2006

18:00

Closing remark
Yasuo Kitagawa (Nagoya Univ.)

18:00 – 20:00

Free discussion (Room Sakura, 2nd Floor)