ȠØŷŵćŒliũ˄­ʴ˕^ƹ<ǎƫ˄ȣʴ˕ǡūˣ˞˸̎˞̔Ʉ
̘ɒɐɑɗ Â÷ǛŔ̙ɄɄɄƻÃŧt̝̦ȠØŷŵćŒliũ.ƮÛƲ˄­ʲʿʛ^ƹ<ǎƫ˙%ʧˉʬʪɝɄɄ ñ̦ȠØŷŵćŒliũ.ƮÛƲ˄ʩʦʿʛ^ƹ<ǎƫˀĿū˙ǉʧʰˁ˙ɄɄ Ʉ Ʉ Ʉ Éʭñʴ˕ʜ̘Ʉ ɤɯɞɡɢɄɒɟ̦ÉʦñɄ ɏɄ ˠ̀˶̔˭˅ǹʗʘɄ ̙Ʉ ɄɄ ñ˅ǭé̦ñ˅ǭé̦ȓçʱ˖ʹ˜˟˷ˢ̉ˆƏÄ˅ˠ̀˶̔˭˅ǹ˄ɄɄ Ʉ Ʉ Ʉ ʩʦʿʛɞɥɦ ˄ȣʲʿ^ƹ<ǎƫʫĐůˀʥʼʹʜʰ˅Ü˄˒ʼʿʛʭ˅ɄɄ Ʉ Ʉ Ʉ ÛƲˆʰ˅Ŀū˙ȓçʴ˕ˁƱʨ˕ʜʹʺʲ ɞɥɦ ˁʦʧ˜˟˷ˢ̉˙˂˅ƇÄɄɄ Ʉ Ʉ Ʉ ȚǕʴ˕ʪ˄ʽʦʿˆÛƲ˅ȚũÄˀť˃˔ʛÉʦñˁʲʹʜɄɄɄƻÃŧt̞̦ȠØŷŵćŒliũ.ƮÛƲ˄­ʲʿʛȺ˙HāƆOʱʶ˕^ƹ<ǎƫ˙%ʧˉʬʪɝɄɄ ñ̦ȠØŷŵćŒliũ.ƮÛƲ˄şʦ˕^ƹ<ǎƫˆʛȺ˙HāƆOɄɄ Ʉ Ʉ Ʉ ʱʶ˃ʦ^ƹ<ǎƫ˒˔ʛȺ˙HāƆOʱʶ˕^ƹ<ǎƫ˙Éʭñʴ˕ʜɄɄ Ʉ Ʉ Ʉ ̘ɤɯɞɡɢɄɒɟ̦ÉʦñɄ ɏɄ ˠ̀˶̔˭˅ǹʗʘ̙ɄɄ ñ˅ǭé̦ȓçʱ˖ʹ˜˟˷ˢ̉ˆƏÄ˅ˠ̀˶̔˭˅ǹ˄ʩʦʿʛɞɥɦ ˄ɄɄ Ʉ Ʉ Ʉ ȣʲʿȺ˙HāƆOʴ˕^ƹ<ǎƫʫĐůˀʥʼʹʜʰ˅Ü˄˒ʼʿʛɄɄ Ʉ Ʉ Ʉ ʭ˅ÛƲˆȺ˙HāƆOʴ˕ǎƫ˙ȓçʴ˕ˁƱʨ˕ʜʲʪʲ ɞɥɦ ˁɄɄ Ʉ Ʉ Ʉ ʦʧ˜˟˷ˢ̉˙˂˅ƇÄȚǕʴ˕ʪ˄ʽʦʿˆÛƲ˅ȚũÄˀť˃˕ʜɄɄ Ʉ Ʉ Ʉ ˌʹȞĒ%ş˄ʧpc˅Q˄ʽʦʿǪą˙]ʮʹÛƲ˅˄ˆʛɄɄ Ʉ Ʉ Ʉ ȓç˙ʲ˃ʦÛƲˏʥ˔Ð˕ʜɄ

Ʉ
Ʉ
Ʉ
Ʉ

1

̕Ėǡūˣ˞˸̎˞̔˅ŰŮɄɄ Ėǡūˣ˞˸̎˞̔ˆʛȠØŷŵćŒliũ̘ʅɸʉʊʈʋɹʊɿʌɻɄ ʉʂɻɻʆɄ ɷʆʄɻɷɚɄ ɬɰɞ̙˅
ĿūŁ˅ʽˀʥ˕^ƹ<ǎƫĿū̘ʅʈɷʂɄ ɷʆʆʂɿɷʄɹɻɚɄ ɬɞ̙˄ȣʲʛ~ȬŮ˄ĉZʲʿʦ˕ ɤɯɞɡɢ ˫˭˵̉˄ʾʦʿƅŮ˄@Ğ˙ǉʦʛȒA˃ƻÃDÿ˙ǉʧʹˎ˅ñ˙ó'ʴ˕ʰˁ˙ŰŮˁʲʿʦ˕ʜɄɄ ˃ʩʛŷŵȭ§~Ȭ@Ȼƍ ɓ ŔɉɞɞɰɪɄ ɦɠɰɡɍɓɊ˅ǡÿŌ˅ĄĖǨǠ˄ŲÌʴ˕ˏ˅ˆ ɒɐɑɗ Â ɕ ďśʛʲ˃ʦʜʰ˅ʹˎ ʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄɻɷ ˁʦʧşǨ˙ȠØŷŵćŒliũˁʲʛHˌˀ%şʱ˖ʿʬʹȠØŷŵćŒliũ.Ʈ
ˁdƯˁʲʿĖǡūˣ˞˸̎˞̔ˀˆåʧʜɄɄ̕Ėǡūˣ˞˸̎˞̔˅%şƲɄɄ ɬɰɞ ˅ÛƲʩ˒ˇ¨ăʛǡūˈ˅Ïʦ˕ʜɄɄ˙ȣ*˃ʭƦʿ˅TūÏ̕Ėǡūˣ˞˸̎˞̔˙%şʴ˕Ȭ˅łÝƲ˙­ǳˁʲʿȵɄɑɎĖǡūˣ˞˸̎˞̔ˀˆʛɬɰɞ ˅ǡÿʛɬɞ ˅Íá˄ȣʴ˕¤Ư˙ǉʼʿʩ˔ʛƻÃDÿ˄%şʴ˕Ȭ˄ˆʛʰ˅ő˙U@Ʊâʱ˖˕ʰˁʜɄɒɎɄ Ėǡūˣ˞˸̎˞̔ˆèÌ˅T¾ːĴƅT¾˅Dÿ˙ĘƩʴ˕ˏ˅ˀˆ˃ʦʜɄɓɎɄ Ėǡūˣ˞˸̎˞̔˙T ƚ ̕TūǍD˅Ǹýˁʲʿşʦ˕ʰˁˆʛĖǡūˣ˞˸̎˞̔˅ŰŮʪ˓ȌƸʴ˕ʜɄɔɎĖǡūˣ˞˸̎˞̔ˆʛ®Ě÷Ǜʴ˕ʰˁ˙ ¤ʲʿʦ˕ʜɄ

̕Ėǡūˣ˞˸̎˞̔˅Fş+ȋ˅¸ɄɄ ɒɐɑɓ Â˄ĄĖŷŵĴƅ˄ʿƑ¤ʲʹǡūˣ˞˸̎˞̔ˁdĩʛĄĖŷŵĴƅ
˅̖̖̆̉̅ˬ˄òȁʲʛǫˏʫ˱˟̖̔̒˸`ƶ˃ŗáˁʲʛ9ǋʴ˕ʜɄ
ɄɄ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ

2

̊̔̕˾̖ʩ˒ˇFůŲ[̘ɠɬɦ̙˅ŢjɄ ʢä´ˆ˿˻̐ǰćő˅ˏ˅ʣɄ
^ƹ<ǎƫǡūˣ˞˸̎˞̔ñȋȓ¤ȕqɄɄ qȞ̦ē¡ȯɄ Ʉ ĄĖĴȕ^ƹƅǮÅɄ ̘ĄĖŷŵĴƅɄ Ŝ Ȟ̙ɄɄ Ʉ Ʉ q̦ǆɄ ŃɄ Ʉ ěàÚTƅɄ ǃȽTūˮ̔˰̖ɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ ̦<µɄ ŴɄ Ʉ ĄĖTȕƗƀTƘƗƀT@țɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ħXWĭɄ Ʉ ˁʭʲʯlix˥̏˺˳˥ɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ŇļÒţɄ Ʉ ƄŠTȕƀơȍOxǮÅɄ Ɨƀƅ@țɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ ̦Ąċ±ĭɄ Ʉ ˨˭̋˭ĴƅTȧȾĮ˥̏˺˳˥Ʉ

Ʉ^ƹ<ǎƫǡūˣ˞˸̎˞̔Ʉ ̖̓ˤ̔˦˦̖̐̃ɄɄ ̖̓ˤ̔˦˦̖̐̃Ȟ̦µĖŸšɄ Ʉ ¼Ƌ{Ą¼ŨȧĴƅ^ƹƅɄɄ Ʉ ̕ˠ̀˶̔˭̖̑̀̌˦̖̐̃ɄɄ Ʉ Ʉ ˦̖̐̃Ȟ̦ėɄ kÁɄ ěTƅĴƅĴȕȥ´ŨȧɄ ÖŵĴƅ̘ʦˇʬ̕Œli̙ĚɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ q̦ț0ȔɄ ȤĴȕȥ´ŨȧɄ Ⱥ^ƹįƶĿūȕɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ǙǱɄ «Ʉ Ʉ ōǷTƅɄ ŷŵǉOTǮÅ̕ŷŵˮ̔˰̖ɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ŠǷɄ Ʉ Ʉ ̧̨ěƦcŨȧɄ Ĵƅ^ƹƅ̕ɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ɃțƳɄ Ʉ ʹʽ˅źĳĴƅ˥̏˺˳˥ɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦_ĮąüɄ Ʉ ÞŸTƅɄ ȧTżƉƅɄ ^ƹƅɄ Ʉ ̕ñü$ã˦̖̐̃ɄɄ Ʉ Ʉ ˦̖̐̃Ȟ̦Îǆ£Ʉ Ʉ ʹ˗ʧĴƅ˥̏˺˳˥̕Ĝǝ×ŨȧɄ Ĵƅ^ƹƅ̕ȤĴƅɄ ^ƹƅƍǮÅɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ q̦"ǆȏɄ Ʉ ěĴƅˡ̖̎̐̊˶˝˫̔̕^ƹƅǮÅɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦"ǆ5ŞɄ Ʉ ěTƅĴƅȧTĴƦcżƉƅĴùƴ˫˭˵̉ǣ(@țɄɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ ̦ŐŠɄ 2Ʉ Ʉ ȃŦTȕĴƅ^ƹƅù¦ɄɄ^ƹ<ǎƫǡūˣ˞˸̎˞̔

P³Ʉ

Ʉ ŕ¤ȳvFńOŁɄ ĄĖŷŵĴƅɄ

P³@¦ɄɄ ʤɑɑɕɍɐɐɕɕɄ ěȖRSǺưǑ ɖɍɓɑɍɕ̘Ģ̙Ǌſ<ɄɄȕǣ(qɄɄ µ0Ʉ Ʉ ȖȧTżƉƅɄɄ ŊŅƃȏɄ Ʉ ǲĮTūˮ̔˰̖Ĵƅ^ƹƅɄ

Ʉ
Ʉ
Ʉ
Ʉ

3

˿˻̐ǰ̊̔˾̖̘˿˻̏˭˷̙Ʉ
ĴƅT¾˿˻̘̐ɖ e̙ɄɄ ŘɄ ǀƭɄĄĖĴƅĀŏŨȧɄ ƦcǡūƅɄ ŷŵĴƅˮ̔˰̖Ʉ

Ʉ 7ĽɄ ȏüɄTūŁɄ ȏüɄ źĳĴƅɄ7Ľ˥̏˺˳˥̕ƂǺUŨȧɄ Ĵƅ^ƹƅɄɄ ¶Ʉ rbɄƿųƋTƅ^ƹƅǮÅɄɄ "ʝŞɄ Æ£ɄʱʱʩĴƅ˥̏˺˳˥Ʉ ^ƹįƶˮ̔˰̖ɄɄ ŐŠɄ 2ɄȃŦTȕĴƅ^ƹƅù¦ɄɄ ɁǔɄ ȋɄ·ĴƅĴȕĴƅ^ƹįƶǮÅȺ^ƹİõ>ĨƔ@țɄ

T¾˿˻̘̐ɓ e̙ɄɄ <µɄ ŴɄĄĖTȕƗƀTƘɄɄ ȞǱ¶Ʉ Ʉ ǩɄ4ěTƅĴƅĴƅŷŵliȭ§ƒŜǮÅɄɄ ˴ğɄ ǏºɄǈǰȧǰq̘̙˨̊˶˝ˢ̐˿˻̘̐ɒ e̙ɄɄ ¶Ʉ ŭaɄěĴƅ¼¶ƦcŨȧƻÃĤġƅ̦ƻÃĤġæ¾ɄɄ ǁcɄ ŸĳɄĄĖĴƅȥ´ŨȧɄ ǡūVKȕɄ Ĵƅæ¸¦̦Ĵƅæ¸ɄÛƲ˿˻̘̐ɔ e̦^ƹ<ǎƫ%şÛƲ̙ɄɄ ƖµɄ ĳɄɄ ŠɄ oWɄ ɄɄ ȂɄ ƃĭɄɄ ĽɄ ĆȯɄɄɄɠɬɦ ˅ŢjǗɄ

Ʉ

Ʉ

Ʉ

qeɄ

èÌȕȟɄ

ơŉŮ ɠɬɦɄǊŮ ɠɬɦɄ

ē¡ȯɄ Ʉñȋȓ¤ȕqɄ

˃ʲɄ

˃ʲɄ

ǆɄ ŃɄ

ñȋȓ¤ȕqɄ˃ʲɄĄĖŷŵɄ ˣ˞˸̎˞̔qɄ qɄ<µɄ ŴɄ

ñȋȓ¤ȕqɄ˃ʲɄ˿˻̏˭˷Ʉ

ĄĖŷŵɄ ˣ˞˸̎˞̔qɄ qȞɄħXWĭɄ Ʉñȋȓ¤ȕqɄ

˃ʲɄ

˃ʲɄ

ŇļÒţɄ

ñȋȓ¤ȕqɄ˃ʲɄĄĖŷŵɄ ˣ˞˸̎˞̔qɄ qɄĄċ±ĭɄñȋȓ¤ȕqɄ

˃ʲɄ

˃ʲɄ

µĖŸšɄ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

4

ț0ȔɄ̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

ǙǱɄ «Ʉ

̖̓ˤ̔˦˦̖̐̃Ʉ

ªǮÅ̘ɒɐɑɖ Â̙Ʉ˃ʲɄ̶̷̶̯̲̻̮̳̬̯ĢÇſʛ̶̷̶̯̲̻̮̳̬̯ōĢÇſʛʹ˃ʪŷŵ˥̏˺˳˥ʛ̶̸̶̫̬̼̱̪̹
̵̴̱̼̺̯̱cdſʛʥʬʹŷŵ˥̏˺˳˥ʛĢÇſ̭̮̭̮̰̭ɄŠǷɄ Ʉ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

ɃțƳɄ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

_ĮąüɄ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

Îǆ£Ʉ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

"ǆȏɄ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

"ǆ5ŞɄ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

ŐŠɄ 2Ʉ

̖̓ˤ̔˦˦̖̐̃Ʉ

˃ʲɄ

˃ʲɄ

˿˻̏˭˷ɄŘɄ ǀƭɄ˿˻̏˭˷Ʉ

˃ʲɄ˃ʲɄ

7ĽɄ ȏüɄ˿˻̏˭˷Ʉ˃ʲɄ

˃ʲɄ¶Ʉ rbɄ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄ"ʝŞɄ Æ£Ʉ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄɁǔɄ ȋɄ

˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄȞǱ¶Ʉ Ʉ ǩɄ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄ˴ğɄ ǏºɄ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄ¶Ʉ ŭaɄ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄǁcɄ ŸĳɄ˿˻̏˭˷Ʉ

˃ʲɄ

˃ʲɄ

ƖµɄ ĳ

Ʉ

˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄŠɄ oWɄ˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄȂɄ ƃĭɄ

˿˻̏˭˷Ʉ˃ʲɄ˃ʲɄĽɄ ĆȯɄ˿˻̏˭˷Ʉ

˃ʲɄ

˃ʲɄ

Ʉ

̕ǸȝɄ
Ʉ Ėǡūˣ˞˸̎˞̔ˆ˅żƉơǶ˙ˏʼʿ$ãʱ˖ʹʜɄɄ ɫɭɬ ŁĄĖŷŵĴƅǡūˣ˞˸̎˞̔$ãqơǶɄ5̛̝ƻÃŧt̘ɹʂɿʄɿɹɷʂɄʇʋɻʉʊɿʅʄɚɄɠɮ̙Ʉ
ɠɮɑɎɄ ȠØŷŵćŒliũ̘ʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄɻɷɚɄɬɰɞ̙˄­ʲʿʛɄɄ Ʉ Ʉ Ʉ Ʉ ^ƹ<ǎƫĿū̘ʅʈɷʂɄɷʆʆʂɿɷʄɹɻɚɄɬɞ̙ˆʛĐNʪɄɠɮɒɎɄɬɰɞ˄­ʲʿʛHāƆOȜ˅ʬʦɬɞˆʛHāƆOȜ˅¯ʱʦɬɞ˒˔ĐNʪɄɄ

̛̞|˅ ɠɮ ˅ȓç˅ƵĊɄɄ ĄĖŷŵĴƅˆʛɒɐɑɓ Â˄ʞȠØŷŵćŒliũ.ƮÛƲ˄­ʲʛ^ƹ<ǎƫĿū˙ǉʧˁʛ˅ĿūˁĺȀʲʿʛȠØŷŵćŒliũ.Ʈˆ÷uʴ˕ʪʟˁʦʧ ɠɮ ˄­ʴ˕ǡūˣ˞˸̎˞̔˙$ãʲʹʜɄɄ ʷ˅Îˏǡūˣ˞˸̎˞̔$˔˅ƣƤʲʹ ĥˁʲʿʛĀʹ˄ǡūˣ˞˸̎˞̔$ã̖̓ˤ̔˦˦̖̐̃ʫƧãʱ˖ʛɠɮ ˄ȣʴ˕ǰʫǉ˘˖ʹʜÌCʛ^ƹ<ǎƫ˄ȣʴ˕NĠD¤˅ʹˎ˅ŷŵĤġ˄ȣʴ˕ ɠɮ ʫĤǜʱ˖ʹʫʛŷŵĤġ˅ƈȻˁjʱ˖˕ǭü˅tȸ˙hˎʿʛÝǔ˙Ȱƙʱʶ˕ʰˁʫ}ȲˀʥʼʹʜɄɄ āʛ^ƹ<ǎƫˆĩ˃Íá˙ëʽʫʛĄĖˀˆ,ȩǡū˄˒˕ǡūȗ˅;cʦʪ˓ʛȺ˙Hā˄ƆOʱʶ˕˰˞̃ˀ#˅ˏ˅ʫĉZʲʿʦ˕ʜ~<ˀʿ˚Qʱ˖ʹ^ƹ<ǎƫĿū˙ʴʴˎ˕ʹˎʛĄĖŷŵĴƅˁʲʿˏʛĪŌŮ˃ǎƫ˅$ãŁ˙žʴÔǒʫ÷ˎʿŽǧʱ˖ʹʜʷ˅HĸȫˁʲʿʛȺ˙Hā˄ƆOʲʹˊʧʫĖÌ˄ƿʦ˅ʪ˙ʛˌʵĤǢʴ˕ʰˁˁ˃ʼʹʜɒɐɑɕ Â ɘ ďʛʠȠØŷŵćŒliũ˄­ʲʛHāƆOȜ˅ʬʦ^ƹ<ǎƫĿūˆʛHāƆOȜ˅¯ʱʦ^ƹ<ǎƫ˒˔ĐNʪʡˁʦʧ ɠɮ ˙ƋʻʯʹʜɄɄ ¥Ȭ˄ʛȺ˙HāƆOʱʶ˕^ƹ<ǎƫĿūˁHāƆOʱʶ˃ʦ^ƹ<ǎƫˁ˙ĺȀʲʹƻÃżƉ˙ƥƬŮ˄ĤƜʲʹʜƢĠʛĺȀˁ˃˕HāƆOʱʶ˃ʦ^ƹ<ǎƫ˄ˆʛǎƫ˅ÍáˆdʳˀȺ˙HāƆOʱʶʿʦ˃ʦˏ˅̘Ɇɑ̙ˁʛȺʥ
˕ʦˆȺ˅˂ʻ˓ʪ˄̃̎˭˲˳˥˅ĝ˅˒ʧ˃ˏ˅˙ǎŶʴ˕ˏ˅̘Ɇɒ̙˅ƈȻʫʥʼʹʜʲʪʲʛɆɒ ˆŴ˄ʛȺ˙HāƆOʱʶ˃ʦ^ƹ<ǎƫˀˆ˃ʦʜɄ
Ʉ ʷʰˀʛɆɑ ˁ˅ĺȀ˙Ǭˉʹ ɠɮɒʢÌC˅ ɠɮ ˄ȃʦˏ˅ʣ˅˄ʛɆɑ ˁɆɒ ˙­œˁʲʹ ɠɮɑ ˙Āʹ˄Ǟ¤ʲʛʰ˅Ɇɑ ˁɆɒ ˙ʥ˘ʶʹ­ǳˆ̃̎ˮ̇˅ǎƫˁʲʿåʼʹʜɓ ÂH˄$ãʲʹǡūˣ˞˸̎˞̔ˀʛ­ǳ˅ʗ˅Ŀūʘ˅ʽˁʲʿĔĿū˙ˁ˔ʥʯʹʫʛʰ˅ĔĿūˁˆ̃̎ˮ̇˅ǎƫˀʥʼʹʹˎʛɠɮɑ ˆH|˅ČĀŔˁʲʿ˅ ƫʮˏëʽʰˁˁ˃ʼʹʜɄɄɄ6̛̟ɬɰɞ ʩ˒ˇ ɬɞ ˅¤Ư˄ʽʦʿʢǭüȓçŌ̦ɠɮ̝ˁ ɠɮ̞:ȈʣɄɑ̙ɬɰɞ ˄ʽʦʿɄ
Ơˍ7˖ŌɄɄ ɉɑɊǝ˅ʦʵ˖ʪ˅ǡÿŌˀ ɬɰɞ ˁǡÿʱ˖ʹÛƲɄɄ Ʉ ̕ɑəəə ÂɄ Ɩ~ŷŵTɉɞɞɰɪɊ˅ǡÿŌɄɄ Ʉ ̕ɒɐɐɕ ÂɄ ŷŵȭ§~Ȭ@Ȼƍ ɒ ŔɉɞɞɰɪɄ ɦɠɰɡɍɒɊ˅ǡÿŌɄɄ Ʉ ̕ɒɐɑɔ ÂɄ ŷŵȭ§~Ȭ@Ȼƍ ɓ ŔɉɞɞɰɪɄ ɦɠɰɡɍɓɊ˅ǡÿŌɄɄ ʚɒɐɑɔ Â˅ ɦɠɰɡɍɓ ˅ǡÿŌˆĎĀˀʥ˕ʫʛüř˄˒˔ǡÿŌʫť˃˕ɄɄ cʛʷ˅ćˀşʦ˓˖ʿʦ˕Ō˙ïşʴ˕ʰˁʫÌˁƱʨʹʜɄɄ ɉɒɊɄ Ɵŷŵ̈̏˯̉˼˦̎́˝̖Ĥġ˄ʿǡÿʪʽĿūǣ(ʫǉ˃˘˖ʿʦ˕ɄȨŌɄɄ ̕ɑɘ ĵĔŋɄɄɒɊɄɬɞ ˅¤Ư˄ʽʦʿɄ
Ôǒ˃ęɄɄ ̕ȺʫHā ˀ,ëʱ˖˕ʰˁˀNĠ˙Ŭôʴ˕ÍáɄɄ ̕ȺHāƆOȜ˅˰˞˷̖̑˫̘̍̔^ƹ<ǎƫ˅$ã˄ʥʹʼʿȺ˅HāƆOȜɄɄ Ʉ Ʉ ˙Ǟ¤ʴ˕ȉ˅ö$̙ʫ˃ʱ˖ʿʦ˕Ʉ
Ȩʴ˕ęɄɄ ̕ƾʫHā ˀ,ëʱ˖˕ʰˁˀNĠ˙Ŭôʴ˕ÍáɄɄ ʚȡ^˙GȦʴ˕Íáˀʥ˕ʪ˅ęˆ|ʛ¤Ư˄hˎʿʦ˃ʦɄ
Ʉ̛̠˜˟˷ˢ̉˄ʽʦʿɄ ʢɠɮ̝ˁ ɠɮ̞:ȈʣɄɄ Ǟ¤ʲʹ˜˟˷ˢ̉ˆ˅ ɘ ȵŰ̘ɑɐ ƝȵŰ̙ˀʥ˔ʛĎƟŮ˄˿˻̐ǰ˄ʩʦʿȚǒÄ˅cÝÍã˙ǉʼʹʜɄɄɄ ɑɎɄ Œli!liìûɄ ɄɉɞʆʄɻɷɄɥʏʆʅʆʄɻɷɄɦʄɺɻʎɊɄɄȚɄɄ ɒɎɄ Ď!OƷǇȘƛȼoÄɄɉɩʅʍɻʉʊɄɰʆɬɒɊɄ ɄɄȚǒɄɄ ɓɎɄ ǖș[ÕìûɄɄɉɞʈʅʋʉɷʂɄɦʄɺɻʎɊɄ ɄɄȚǒɄɄ ɔɎɄ ˠ̖̃̓˭ŵĻ²ÄɄɉɢʆʍʅʈʊɾɄɰʂɻɻʆɿʄɻʉʉɄɰɹɷʂɻɊɄȚǒɄɄ ɕɎɄ Şń˅ǹɄɕɍɑɎɄ ǽ#Ů˃0Æ²ÄɄɉɰɣɍɓɖɄɭɾʏʉɿɹɷʂɄɠʅʃʆʅʄɻʄʊɊɄ
ȚɄɄɄɕɍɒɎɄ ƗƀŮ˃0Æ²ÄɄɉɰɣɍɓɖɄɪɻʄʊɷʂɄɠʅʃʆʅʄɻʄʊɊɄȚɄɄ ɖɎɄ ĶŚɄ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
ȚɄ

7

Ʉ ɗɎɄ ÓǇƒƘ˞̄̔˷Ʉ ɄɄɄɄɄɄ ɘɎɄ ǇɄɘɍɑɎɄ ɒɔ ćȢ\ƪĒǇɉɒɔɾɄɰʏʉʊʅʂɿɹɄɸʂʅʅɺɄʆʈɻʉʉʋʈɻɊɄ
ɄɄɘɍɒɎɄ ɒɔ ćȢêÊĒǇɉɒɔɾɄɡɿɷʉʊʅʂɿɹɄɸʂʅʅɺɄʆʈɻʉʉɊɄ
Ʉ

ȚɄ
ȚɄ
ȚɄ

̡̛ǭüȓç˅ƢĠʩ˒ˇĤƜÇɄɒɐɑɕ Â ɑɒ ď ɑɐ Ą˄ ɭʋɸɪɻɺ ʩ˒ˇ˽̔˸˩̖˲˄ʿĤƜ˙ǉʦʛɒɘɘ ǭü˙ȓçʲʛĖ ɠɮ ˅ǭüȓçŌ˙˄ĎƟŮ˄ ə ǭüʫȓçʱ˖ʹʜˌʹʛTȱǦˆʛɒɐɑɕ Â ɑɒ ď ɑɐ Ą˄ĤƜ˙ǉʦʛɒɑ ǭü˙ȓçʲʹʫʛʦʵ˖ˏȨʱ˖ʹʜ˃ʩʛĤƜÇˆ ɠɮ̝ˁ ɠɮ̞ˁˏ˄dʳˀʥ˕ʜɄ
̚Ȩǭü˅ǗǋˆȅMǸýˁʲʿ»ĕ˄óžʲʿʦ˕ʜɄ
ɄɪɻɺʂɿʄɻɄ ̘ɆɑɄɞɫɡɄɆɒɄɞɫɡɄɆɓ̙ɄɆɑɄ ɅʉʂɻɻʆɅɵɞɩɩɶɄ ɞɫɡɄ ɉɅɷʆʄʅɻɷɅɵɞɩɩɶɄ ɬɯɄ ɅɷʆʄɻɷɅɵɞɩɩɶɄ ɬɯɄ ɅɾʏʆʅʆʄʅɻɷɅɵɞɩɩɶɄɬɯɄ ɅɾʏʆʅʆʄɻɷɅɵɞɩɩɶɊɄ ɬɯɄ ɅʉʂɻɻʆɄ ɺɿʉʅʈɺɻʈɻɺɄ ɸʈɻɷʊɾɿʄɽɅɵɞɩɩɶɄ ɬɯɄ ɅʉʂɻɻʆɄ ʈɻʂɷʊɻɺɄ
ʈɻʉʆɿʈɷʊʅʈʏɄɺɿʉʅʈɺɻʈʉɅɵɞɩɩɶɄɬɯɄɅʉʄʅʈɿʄɽɅɵɞɩɩɶɄɬɯɄɅʉʂɻɻʆɄɷʆʄʅɻɷɄʉʏʄɺʈʅʃɻʉɅɵɞɩɩɶɄ
ɬɯɄɅʉʂɻɻʆɄɷʆʄɻɷɄʉʏʄɺʈʅʃɻʉɅɵɪɥɶɄ
ɄɆɒɄɉɉɅʅʈɷʂɅɵɞɩɩɶɄɬɯɄɅʃɷʄɺɿɸʋʂɷʈɅɵɞɩɩɶɄɬɯɄɅɺɻʄʊɷʂɅɵɞɩɩɶɊɄɞɫɡɄɉɅɺɻʌɿɹɻɋɅɵɞɩɩɶɄ
ɬɯɄɅʉʆʂɿʄʊɋɅɵɞɩɩɶɄɬɯɄɅɷʆʆʂɿɷʄɹɻɋɅɵɞɩɩɶɊɄɬɯɄɅʃɷʄɺɿɸʋʂɷʈɄɷɺʌɷʄɹɻʃɻʄʊɅɵɞɩɩɶɊɄ
ɄɆɓɄ ɉʈɷʄɺʅʃɿʐɻɺɄɹʅʄʊʈʅʂʂɻɺɄʊʈɿɷʂɄɵʆʊɶɄɬɯɄɹʅʄʊʈʅʂʂɻɺɄɹʂɿʄɿɹɷʂɄʊʈɿɷʂɄɵʆʊɶɄɬɯɄʈɷʄɺʅʃɿʐɻɺɄ
ɵʊɿɷɸɶɄɬɯɄʆʂɷɹɻɸʅɄɵʊɿɷɸɶɄɬɯɄɺʈʋɽɄʊɾɻʈɷʆʏɄɵʉɾɶɄɬɯɄʈɷʄɺʅʃʂʏɄɵʊɿɷɸɶɄɬɯɄʊʈɿɷʂɄɵʊɿɷɸɶɄɬɯɄ
ɽʈʅʋʆʉɄɵʊɿɷɸɶɊɄɫɬɱɄɉɷʄɿʃɷʂʉɄɵʃɾɶɄɫɬɱɄɾʋʃɷʄʉɄɵʃɾɶɊɄ
Ʉ
TȱǦɄ ̘ɆɑɄɞɫɡɄɆɒɄɞɫɡɄɆɓ̙ɄɆɑɄ ɉŷŵćŒliũ.ƮɏɱɥɄ ʅʈɄ ŷŵćŒliũ.ƮɏɞɩɊɄ ʅʈɄ ɉɉŷŵɏɱɥɄ ʅʈɄʉʂɻɻʆɏɞɩɊɄɷʄɺɄɉŒliɏɱɥɄʅʈɄɷʆʄɻɷɏɞɩɊɊɄ ɄɄɆɒ Ʉ ɉ ˡ ˥ ̐ ̖ ˪ ̐ ˭ ̃ ̏ ̔ ˷ ɏɱɥɄ ʅʈɄ ^ ƹ < ǎ ƫ ɏɞɩɊɄ ʅʈɄ ɉʅʈɷʂɏɞɩɄ ɷʄɺɄɷʆʆʂɿɷʄɹɻɏɞɩɊɄ
ɄɆɓɄ ɉɯɡɜ̊˰˜˹̏˫˭Ɍ̎̔˱̉QĺȀǤȿɌŌ̎̔˱̉QĺȀǤȿɌĺȀżƉɌǡūˣ˞˸̎˞̔ɊɄ
Ʉ

8

CQ1 文献検索フローダイヤグラム(PRISMA2009改変)

同
定

ス
ク
リ
ー
ニ
ン
グ

データベースで同定された研究
n=309
Medline(PubMed)
288件
医中誌
21件

他のリソースから同定された研究
n=0

検索で同定された研究
n=309

重複研究
n=2

重複研究を除外した研究
n=307

除外基準に該当した研究
n=286
CQの主旨とは異なる研究 286件

フルテキストで適格性を比較した研究
n=21

適
格
性

除外基準に該当した研究
n=12
RCTではない4件
治療評価がPSGではない
7件
OAの開口量に関する研究1件

質的統合に組み入れた研究
n=9

組
み
入
れ

メタアナリシスに組み入れた研究
n=9
無呼吸低呼吸指数
9件
最低動脈血酸素飽和度
5件
覚醒反応指数6件
エプワース眠気尺度
4件
身体的な健康尺度2件
精神的な健康尺度
2件
24時間収縮期血圧2件
24時間拡張期血圧2件

CQ2 文献検索フローダイヤグラム(PRISMA2009改変)

同
定

ス
ク
リ
ー
ニ
ン
グ

データベースで同定された研究
n=309
Medline(PubMed)
288件
医中誌
21件

他のリソースから同定された研究
n=0

検索で同定された研究
n=309

重複研究
n=2

重複研究を除外した研究
n=307

除外基準に該当した研究
n=286
CQの主旨とは異なる研究 286件

フルテキストで適格性を比較した研究
n=21

適
格
性

除外基準に該当した研究
n=18
RCTではない4件
治療評価がPSGではない
7件
OAの開口量に関する研究
1件
プラセボOAのデザインが異なる 6件

質的統合に組み入れた研究
n=3

組
み
入
れ

メタアナリシスに組み入れた研究
n=3
無呼吸低呼吸指数3件
最低動脈血酸素飽和度
1件
覚醒反応指数2件
エプワース眠気尺度
1件
身体的な健康尺度1件
精神的な健康尺度
1件

ïşǭüɄɠɮɑ ˀˆǝ˅ ɑə ˙ʛɠɮɒ ˀˆǝ˅ ɓ ˁ̠ˁ ɘ ˙ïşʴ˕ʰˁˁ˃ʼʹʜɄ
ɄɑɎɪɻɾʊɷɄ ɞɌɄ ɮɿɷʄɄ ɧɌɄ ɭɻʊʅɹʐɄ ɭɌɄ ɡɷʈɻʄɺɻʂɿʂɻʈɄ ɪɞɌɄ ɠɿʉʊʋʂʂɿɄ ɭɞɎɚɄ ɞɄ ʈɷʄɺʅʃɿʐɻɺɌɄ ɹʅʄʊʈʅʂʂɻɺɄ
ʉʊʋɺʏɄʅɼɄɷɄʃɷʄɺɿɸʋʂɷʈɄɷɺʌɷʄɹɻʃɻʄʊɄʉʆʂɿʄʊɄɼʅʈɄʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄɻɷɎɄɞʃɄɧɄɯɻʉʆɿʈɄ
ɠʈɿʊɄɠɷʈɻɄɪɻɺɎɄɒɐɐɑɄɪɷʏɛɑɖɓɉɖɊɚɑɔɕɗɍɖɑɎɄ ̘ ɪɻɾʊɷɌɄɒɐɐɑ̙Ʉ

ɒɎɤʅʊʉʅʆʅʋʂʅʉɄɥɌɄɨɻʂʂʏɄɧɧɌɄɠɿʉʊʋʂʂɿɄɭɞɎɚɄɬʈɷʂɄɞʆʆʂɿɷʄɹɻɄɱɾɻʈɷʆʏɄɯɻɺʋɹɻʉɄɟʂʅʅɺɄɭʈɻʉʉʋʈɻɄɿʄɄ ɬɸʉʊʈʋɹʊɿʌɻɄ ɰʂɻɻʆɄ ɞʆʄɻɷɚɄ ɷɄ ɯɷʄɺʅʃɿʐɻɺɌɄ ɠʅʄʊʈʅʂʂɻɺɄ ɱʈɿɷʂʙɎɄ ɰʂɻɻʆɎɄ ɒɐɐɔɎɄ ̘  ɤʅʊʉʅʆʅʋʂʅʉɌɄɒɐɐɔ̙Ʉ

ɓɎɟʂɷʄɹʅɄɧɌɄɴɷʃɷʈʈʔʄɄɠɌɄɞɸɻʂɻɿʈɷɄɭɷʐʅʉɄɪɱɌɄɩɷʃɻʂɷɄɠɌɄɰʋɷʈɻʐɄɮʋɿʄʊɷʄɿʂʂɷɄɡɎɚɄɭʈʅʉʆɻɹʊɿʌɻɄ
ɻʌɷʂʋɷʊɿʅʄɄʅɼɄɷʄɄʅʈɷʂɄɷʆʆʂɿɷʄɹɻɄɿʄɄʊɾɻɄʊʈɻɷʊʃɻʄʊɄʅɼɄʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄɻɷɄʉʏʄɺʈʅʃɻɎɄ
ɰʂɻɻʆɄɟʈɻɷʊɾɎɄɒɐɐɕɄɪɷʈɛəɉɑɊɚɒɐɍɕɎɄ ̘ ɟʂɷʄɹʅɌɄɒɐɐɕ̙Ʉ

ɔɎɭɻʊʈɿɄ ɫɌɄ ɰʌɷʄɾʅʂʊɄ ɭɌɄ ɰʅʂʅʍɄ ɟɌɄ ɳɿʂɺʉɹɾɿʖɺʊʐɄ ɤɌɄ ɳɿʄʁɻʂɄ ɭɎɚɄ ɪɷʄɺɿɸʋʂɷʈɄ ɷɺʌɷʄɹɻʃɻʄʊɄ
ɷʆʆʂɿɷʄɹɻɄɼʅʈɄʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄʅɻɷɚɄʈɻʉʋʂʊʉɄʅɼɄɷɄʈɷʄɺʅʃɿʉɻɺɄʆʂɷɹɻɸʅɄɹʅʄʊʈʅʂʂɻɺɄʊʈɿɷʂɄ
ʋʉɿʄɽɄʆɷʈɷʂʂɻʂɄɽʈʅʋʆɄɺɻʉɿɽʄɎɄɧɄɰʂɻɻʆɄɯɻʉɎɄɒɐɐɘɄɧʋʄɛɑɗɉɒɊɚɒɒɑɍəɎɄ ̘ ɭɻʊʈɿɌɄɒɐɐɘ̙Ʉ

ɕɎɞɷʈɷɸɄɤɌɄɩʅɸɸɻʐʅʅɄɣɌɄɥɷʃɸʋʈɽɻʈɄɥɩɌɄɫɷɻɿʀɻɄɪɎɚɄɬʈɷʂɄɷʆʆʂɿɷʄɹɻɄʊɾɻʈɷʆʏɄʌɻʈʉʋʉɄʄɷʉɷʂɄ
ɹʅʄʊɿʄʋʅʋʉɄʆʅʉɿʊɿʌɻɄɷɿʈʍɷʏɄʆʈɻʉʉʋʈɻɄɿʄɄʅɸʉʊʈʋɹʊɿʌɻɄʉʂɻɻʆɄɷʆʄɻɷɚɄɷɄʈɷʄɺʅʃɿʐɻɺɌɄʆʂɷɹɻɸʅɍ
ɹʅʄʊʈʅʂʂɻɺɄʊʈɿɷʂɎɄɯɻʉʆɿʈɷʊɿʅʄɎɄɒɐɑɑɛɘɑɉɕɊɚɔɑɑɍəɎɄ ̘ ɞɷʈɷɸɌɄɒɐɑɑ̙Ʉ

ɖɎɺɻɄɟʈɿʊʊʅɄɱɻɿʎɻɿʈɷɄɞɬɌɄɞɸɿɍɯɷʃɿɷɄɩɟɌɄɺɻɄɬʂɿʌɻɿʈɷɄɞʂʃɻɿɺɷɄɪɞɎɄɱʈɻɷʊʃɻʄʊɄʅɼɄʅɸʉʊʈʋɹʊɿʌɻɄ
ʉʂɻɻʆɄ ɷʆʄɻɷɄ ʍɿʊɾɄ ʅʈɷʂɄ ɷʆʆʂɿɷʄɹɻʉɎɄ ɭʈʅɽɄ ɬʈʊɾʅɺɎɄ ɒɐɑɓɄ ɪɷʏɄ ɒɓɛɑɔɚɑɐɎɄ ̘ ɺɻɄ ɟʈɿʊʊʅɌɄ
ɒɐɑɓ̙Ʉ

ɗɎɡɷʂɍɣɷɸɸʈʅɄɠɌɄɤɷʈɸʋɿʅɄɰɌɄɡɈɞʂʃɻɿɺɷɄɲɌɄɠɿʄʊʈɷɄɣɡɌɄɱʋɼɿʁɄɰɌɄɟɿʊʊɻʄɹʅʋʈʊɄɩɎɚɄɪɷʄɺɿɸʋʂɷʈɄ
ɷɺʌɷʄɹɻʃɻʄʊɄɺɻʌɿɹɻɄɷʄɺɄɠɭɞɭɄʋʆʅʄɄɹɷʈɺɿʅʌɷʉɹʋʂɷʈɄʆɷʈɷʃɻʊɻʈʉɄɿʄɄɬɰɞɎɄɰʂɻɻʆɄɟʈɻɷʊɾɎɄ
ɒɐɑɔɄɡɻɹɛɑɘɉɔɊɚɗɔəɍɕəɎɄ ̘ ɡɷʂɍɣɷɸɸʈʅɌɄɒɐɑɔ̙Ʉ

ɘɎɡʋʈʒʄɍɠɷʄʊʅʂʂɷɄɧɌɄɠʈʅʌɻʊʊʅɍɪɷʈʊʓʄɻʐɄɯɌɄɞʂʁɾʈɷɿʉɷʊɄɪɥɌɄɠʈʅʌɻʊʊʅɄɪɌɄɪʋʄɿɹɿʅɄɞɌɄɨʋʊʐɄ
ɯɌɄɞɿʐʆʋʈʋɄɣɌɄɪɿʈɷʄɺɷɄɢɌɄɞʄɿʊʋɷɄɢɎɚɄɢɼɼɿɹɷɹʏɄʅɼɄʃɷʄɺɿɸʋʂɷʈɄɷɺʌɷʄɹɻʃɻʄʊɄɺɻʌɿɹɻɄɿʄɄʊɾɻɄ
ʊʈɻɷʊʃɻʄʊɄ ʅɼɄ ʅɸʉʊʈʋɹʊɿʌɻɄ ʉʂɻɻʆɄ ɷʆʄɻɷɄ ʉʏʄɺʈʅʃɻɚɄ ɞɄ ʈɷʄɺʅʃɿʐɻɺɄ ɹʅʄʊʈʅʂʂɻɺɄ ɹʈʅʉʉʅʌɻʈɄ
ɹʂɿʄɿɹɷʂɄʊʈɿɷʂɎɄɪɻɺɄɬʈɷʂɄɭɷʊʅʂɄɬʈɷʂɄɠɿʈɄɟʋɹɷʂɎɄɒɐɑɕɄɰɻʆɄɑɛɒɐɉɕɊɚɻɖɐɕɍɑɕɎɄ ̘ ɡʋʈʒʄɍ
ɠɷʄʊʅʂʂɷɌɄɒɐɑɕ̙Ʉ

əɎɪɷʈʁʂʋʄɺɄɪɌɄɠɷʈʂɸɻʈɽɄɟɌɄɣʅʈʉɽʈɻʄɄɩɌɄɬʂʉʉʅʄɄɱɌɄɰʊɻʄʂʋʄɺɄɥɌɄɣʈɷʄʁʂɿʄɄɨɞɎɚɄɬʈɷʂɄɞʆʆʂɿɷʄɹɻɄ
ɱɾɻʈɷʆʏɄɿʄɄɭɷʊɿɻʄʊʉɄɳɿʊɾɄɡɷʏʊɿʃɻɄɰʂɻɻʆɿʄɻʉʉɄɷʄɺɄɰʄʅʈɿʄɽɄʅʈɄɪɿʂɺɄʊʅɄɪʅɺɻʈɷʊɻɄɰʂɻɻʆɄ
ɞʆʄɻɷɚɄɞɄɯɷʄɺʅʃɿʐɻɺɄɠʂɿʄɿɹɷʂɄɱʈɿɷʂɎɄɧɞɪɞɄɦʄʊɻʈʄɄɪɻɺɎɄɒɐɑɕɄɞʋɽɛɑɗɕɉɘɊɚɑɒɗɘɍɘɕɎɄ ̘ ɪɷʈʁʂʋʄɺɌɄɒɐɑɕ̙ɄɄɄ9̚Ȩǭü˅ ɞɷʈɷɸɒɐɑɐ̘»ĕ˅Ǘǋ˅ ɫʅɎɄ ɑɓɕ̙ˆdǌȿƲˀ ɔ ĸȫ˄Ⱥ˙HāƆOʱʶ˕ˁʦʧƻÃżƉˀʥʼʹʫʛ˥̒˭ˡ̖˾̖ǤȿʢǌȿƲʫā˅ǎƫ˙%şʲʿʛʷ˅ȑʦ˙Ĥǜʴ˕ƻÃżƉʣˁʲʿåʧˉʬʪDÿʽʪʵʛˌʹ
ı˅Ǥȿ̘ïşǭü ɕ ˅ ɞɷʈɷɸɒɐɑɑ̙˅Ⱥ ˙ľˎ˕ʹˎ˅żƉˁˏƱʨ˓˖ʛȨʲʿʦ˕ʜɄ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ

10

̢̛ȓçǭü˅ǣ(̕ƢĠ˅ˌˁˎɄ ʢɠɮ̝ˁ ɠɮ̞ʣɄ
̏˭˥ˡ̂˾˞˜˭˵̖̂̐ɉɠɮɑɊɄ







80 2







!





































!























































4 4 0















08 011
















































!











4



0 01

















- 45 08

0

0-0 8 3

880


Ʉ

Ʉ

11

ˠ̀˶̔˭̃̒́˛˞̐ɉɠɮɑɊɄ
fCd

9

a

Cc
S

I

D

sxu

C

2

ce

sxu (

8

2

sxu )

ce

C

A

CQ

E
M

)

I

Cf

%

%(

(

ce

)

e]

(-(

(,.

//

),

. ),

ce

)

e]

/.

/.

) () ( /

)-

)

ce

)

e]

.

-.

/ -

( -.

, ),

) ,

ce

)

e]

(

/

(

(/

,

ce

)

e]

-(

-

( )

((

) /

ce

)

e]

-(

-

( .

(.

)

ce

)

e]

/

/

(

ce

)

e]

/

/

()

E O=L (

ce

2

ce

t

ce

w

4L

sxu

sxu ,

e

(

E O

ce

ce

= 5 ), 9 E OAH2 I L

2sxu - (

ce

²

(

-

= 5 ), FS CAH2 I L

2,= CAHE

ce

e

(

ce

MOF = HEEL E

2

/

.

)-.

E O

ce

( F = S O HC H D LME PME

2cesxu . (

ce()

( F 3 A O HC H D LME PME

(

2

ce

b m [h
(

ila h

)

sxu
e

7=

e

ce

o

(

)

)

-)

)

(

ob
7T0 ()

p

b n

h

e

ila h

e

7T0

,

ila h

e

7T0 )

-

ila

m

.

h

/

ila h

e

7T0

ila h

e

7T0

ila h

e

7T0

ila h

e

7T0

Ʉ

]A

gc

1 M P AH7 DER

,

(

i[W

95

1 L EA 6 SL L EA 7 DER

/

sxu

iOe

9

n 7T0 ,
ry r

c

c m

d

]

Ʉ
Ʉ

12

ɰʅɣ ǋɉɠɮɑɊɄ Ʉ

8

PM vyrw8
vyrw
D

I
C E

C

5

9

)(%

I

4S

I

5IA

6

M : 8

--

L OM 5IA

nv

,

- (

- )

,

)-

-)

)

)( -

2

LE :

FI MM :-)c

:3

9 ESMF

0 H

I I

(

(

c

:3

7 I

0 H

I I

, ( ,

(

(

(E : SMFA L MMOL

)

( (

(

(E 1 F M

FA L MMOL((

0 5.0 ICFA I

FI LP

2: : d

f

lmtox

,

7 1.

FDE A Helmtoxd
bc

:3

(

( (

)

,

,

I AFCC L I

f
f

ap
(

h

usm bc ]d []]gaWi lmtoxe

bc

13

d

ɣʅʈɻʉʊʆʂʅʊɉɠɮɑɊɄ
LI
e

O

bO

62 E

lmp

n

s

6D

- C6

S

M H d

62

A 2

) C

6D

66

6

42 6

oP

F

E 42

6

ih

F

6 2

6

ar

cm

E

43

6 A6

ar

cm

(2

43

6 A6

Ʉ
Ʉ

Ʉ

14

Ʉ
̏˭˥ˡ̂˾˞˜˭˵̖̂̐ɉɠɮɒɊɄ



J

ʮ
˅
Ȯ
ǅ

ű
Ĥ
Q
Û
Ʋ
Ʉ

J

ʮ
˅
ȶ
Ť

˜
˟
˷
ˢ
̉

j
˾
˞
˜
˭

ʷ
˅

˅
˾
˞
˜
˭

ɄɄ

ɄɄ

ɄɄ

ɄɄ

ɄɄ

ɄɄ

ɄɄ

ɟʂɷʄɹʅɄɒɐɐɕɄ















ɭɻʊʈɿɄɒɐɐɘɄ















ɡʋʈɷʄɍɠɷʄʊʅʂʂɷɄɒɐɑɕɄ















Ʉ

ɠɮɒɄ

Ʉ

Ʉ


¢
8
˃
˜
˟
˷
ˢ
̉

Ʉ

ű
Ĥ
Q
˜
˟
˷
ˢ
̉

Ʉ

Ʉ

Ʉ
Ʉ

Ʉ

15

ˠ̀˶̔˭̃̒́˛˞̐ɉɠɮɒɊɄ
cCa

9
S

[

[

D

[CeW

f

f

A

C

]

O

C

=3

d

rswuy(

d

8MS FP=3

rswuy)

EI

Cc

%

%(

(

-

-

-/

)/

).

(

d

)

d

)

-

d

)

.

d

)

g

,

(-

(

/

d

)

g

,

(-

(

d

)

g

,

(-

(

(

),A

()

N (

d

=3

rswuy

d

d

tx

d

4NS MO H=3

FFNILFPP

g

,

( A

) ,

d

5 ), H PI=3d5 ), 9 FL

=3

h

g
h

c n ]igrswuyh
²

7

h

mb[i²

d

p
l

) /,

(.A

) -

(

)

A

),.

, ))

))A

),/

)(

. A

),

3 M NMLFL

d

mb[i²

/ (

3 M NMLFLdrswuy,

-

F

d

rswuy

)

pc
7 1 (/

ac o
i

,

l
g

6 F FOM FLFI 0: M

NN I C F

e

-

h

mb[i²

l

71

.

h

mb[i²

l

6 F FOM FLFI 0: M

NN I C F

/

h

mb[i²

l

6 F FOM FLFI 0: M

NN I C F

h

mb[i²

l

6 F FOM FLFI 0: M

NN I C FɄ)

2 OMRP 7LEFT

(

)

d

2 NLF 6 NMNLF 7LEFT

)

(

95

Ag

CM
Q

rswuy

9

Ʉ

Ʉ

16

ɰʅɣ ǋɉɠɮɒɊɄ

dw e
t
m

s

Wl S8

dw

e

x ih
Wl Sg

dw

e

Wn Sg

c
c

OL dw e

D

Wn S8

I
C E

C

5

9

)(%

ih

y

ihuv

e

I L F5H A

-(

))

(

(( ) (-

op 2 P I MD : FAA EHALL :

-

FA

( ,

)

((

]

-

]

)

a

op : 39 D LE F0 I

IHAHM

(

)

a

op : 3

7 AHM F0 I

IHAHM

),

)

0 5.0 IH E AH A EHMA O FɄI HA 5H A

p 6IP ALM : 8

fruv

[

HA 4

7 1 . AECDMAɄA H E A AH A

Ʉ

17ɣʅʈɻʉʊʆʂʅʊɉɠɮɒɊɄ

P
a

e
SM

S

M

hil

n

C-

3 )

o

3

m

H

P

e

n

EC-

23A

-

6 23A

LIc

d

3

633

FO

(

FO

(

3

3

63

6

3

6

3

Ʉ
Ʉ

Ʉ
Ʉ
Ʉ
Ʉ
ɋ́˛̔˻̐̃̒˳˷ˆʦʵ˖˅ ɠɮ ˏ ɑɐ Ĕŋ˅żƉˀʥʼʹʹˎóžʲʿʦ˃ʦʜɄ

Ʉ

18̛̣Ⱥ˙Hā˄ŖÈʴ˕ǎƫ˅§̕I$ş˄ʽʦʿɄɄ ĄĖŷŵĴƅˀH|$ãʲʹǡūˣ˞˸̎˞̔˄óžʲʹd<©˅ĦǒˆˀʥʼʹʞŹĒŮ˃%ş˄˒˕ȺȣƓ˅ŪˍːĴ˅Țƕ˃ȭ§ˆˊˁ˚˂jʱ˖ʿʦ˃ʦʜʲʪʲʛȞĒŮ˃%ş˄˒˕pcQ˅jʫúǔʱ˖ˎʿʦ˕ʟɄɄ ÷ˎʿ| ɬɞ ˄ȣʴ˕§̕I$ş˄ȣʲʿʛïşǭü<ˀȄˉ˓˖ʹˏ˅˙íʯ˕ʜ˃ʩȺ˙Hā˄ƆOʱʶ˃ʦǎƫˁˆ ɬɞ ˁdʳÍá˅ˏ˅ˀʛ̃̎ˮ̇ǎƫˁˆȺ˅˂ʻ˓ʪʺʮ˄ǎŶʴ˕̃̎˭˲˳˥˅ĝ˅˒ʧ˃ˏ˅˙ʱʴʜɄɄ ̚üƌˀ˅ʢʣˆşǨ˅ǪąɄɄɄ Ʉ Ŀūÿ˅Ŝšˁ˃ʼʹI$ş˄ʽʦʿɄɄ ̕ɬɞ ƮˁʛȺ˙Hā˄ƆOʱʶ˃ʦǎƫƮˀˆǎƫˈ˅ÛƲ˅]ʮ7˖ɄɄ Ʉ }ȲːwĻ˄˒˕ÿ˄ʬ˃¹ˆ˃ʦ̘ɟʂɷʄɹʅɌɄɒɐɐɕʛɄ ɭɻʊʈɿɌɄɒɐɐɘ̙ʜɄɄ Ʉ ʹʺʲ ɑɏɓɒ &ˀʥ˕ʫʛȺȣƓŪˀÿʲʹˏ˅ˆ ɬɞ Ʈ˅ˍˀʥʼʹɄɄ Ʉ ̘ɭɻʊʈɿɌɄɒɐɐɘ̙ʜɄɄ ̕ɬɞ Ʈˁ̃̎ˮ̇ǎƫƮ˅˥̒˭ˡ̖˾̖Ǥȿˀˆʛɬɞ ˅%ş˄˒˔ɄɄ Ʉ ɑɏɓə &ʫȺȣƓŪˀÿʲʹ̘ɡɷʂɍɣɷɸɸʈʅɌɄɒɐɑɔ̙ʜdʳ˒ʧ˃<©˅żƉˀɄɄ Ʉ ɬɞ ˅%ş˄˒˔ ɑɏɒɘ &ʫsņȎˀʛɑɏɒɘ &ʫȺȣƓŪˀÿʲʹɄɄ Ʉ ̘ɪɻɾʊɷɌɄɒɐɐɑ̙ʜɄ
ɄɄ Ʉ Ŀū˙¢Ƣʲʹũ&ˀ˅I$ş˄ʽʦʿɄɄ ̕ɬɞ ƮˀsņȎʫ ɒɏɘ &ˀˍ˓˖ʹʫʛHā˄ƆOʱʶ˃ʦǎƫƮˀˆɄɄ Ʉ ˍ˓˖˃ʪʼʹ̘ɟʂɷʄɹʅɌɄɒɐɐɕ̙ʜɄɄ ̕Țƕ˃I$şˁʲʿ`ȆŮ˃pc˅Qʫ ɬɞ Ʈ˅ ɕɏɔɒ &ˀˍ˓˖ʛɄɄ Ʉ Ⱥ˙Hā˄ƆOʱʶ˃ʦǎƫƮˀˆˍ˓˖˃ʪʼʹɄɄ Ʉ ̘ɡʋʈɷʄɍɠɷʄʊɷʂʂɷɌɄɒɐɑɕ̙ʜɄɄ ̃̎̕ˮ̇ǎƫƮˀˆI$şˆŒʦʫʛɬɞ ƮˀˆǻÃć˅Ĵ˅ȎøũŗʛɄɄ Ʉ ǻÃć˅pƐȕ˅ŪʛǻÃć˅pc˅ȑoßʛsņȎʛ^ňßʛǎŶćɄɄ Ʉ ˅y}Ȳʫˍ˓˖ʹ̘ɞɷʈɷɸɌɄɒɐɑɑ̙ʜ˃ʩʰ˖˓˅I$şˆʛʦʵ˖ˏɄɄ Ʉ ǿÄʪ˓ƏÄˀʥʼʹ̘ɪɻɾʊɷɌɄɒɐɐɑ̙ʜɄɄɄ ˙ˌˁˎ˕ˁʛƙ ɓɇƇÄˀ ɬɞ ŕĐ˅I$ş̘ȺȣƓŪʛsņȎƏ̙˄˒ʼʿ
Ŀūʫÿʱ˖ʿʦʹʜˌʹȺ˙Hā˄ƆOʱʶ˃ʦǎƫˁˆ ɬɞ ˁdʳÍáˀʥ˕ʹˎʛǎƫˈ˅ȑoß˄˒˕ÿˆʛȺ˅HāƆO˅ĐŒ˄˒˓˃ʦˏ˅ˀʥ
ʼʹʜɄ
Ʉ

19

Ʉ Ŀū˙¢ƢʲʹÛƲ˅I$ş˄ˆʛǎŶć˅wf˄˒˕ƊÙˁʦʼʹŞm Î˄ȣ˘˕ˏ˅ˆ˃ʪʼʹʜʷ˅ˀʛǻÃć˅Ⱥ˅ȑoßːsņȎˁʦʼʹʭ˅
I$şˆĿūʫ¢Ƣʱ˖ʿʦ˕ŗŀʪ˓ʛÛƲʫ]ʮ7˖˓˖˕ƇÄ˅ˏ˅ˀʛǭüˀˆǿÄʪ˓ƏÄ˅I$şˁǋśʱ˖ʿʦʹʜɄɄ ɡʋʈɷʄɍɠɷʄʊɷʂʂɷɌɄɒɐɑɕ ˅jˀʗȚƕ˃I$şʘˁǋśʱ˖ʹʞ`ȆŮ˃pc˅
QʟˆŕƎʴˉʬˏ˅ˀʥʼʹʜķ×˃ʫ˓ʛʷ˅ǥƝ˅ǝȁʫǭü˄ˆ˃ʪʼʹ
ʫʛŞm Î˄ȣ˘˕I$ş˅jʫŒʦ ɬɞ ˄ˁʼʿʛʰ˅ʞ`ȆŮ˃pc˅
QʟʫʗȚƕ˃I$şʘˁʲʿǧǯʱ˖ˎʿʦ˕ʜɄɄɄ ʞ`ȆŮ˃pc˅Qʟ˄ȣʲʿˆʛĴ˅3þːǌǄʢȺ˅ĴʫʛȺ˅Ĵ˙Ǔʧŗáʣ˅Qʫjʱ˖ʿʦ˕ʫʛnzˁʦʧįƶ˄ʩʦʿƽĴȕ˅ȡpʢʪˍc˘˃ʦʰˁʣʫŕ˄tȸˁ˃ʼʿʦ˕ʜɄɄ ʰ˅ƽĴȕ˅ȡpˆ ɭʅʉʊɻʈɿʅʈɄʅʆɻʄɄɸɿʊɻɚɄɭɬɟ ˁǋśʱ˖ʛśŗ ɬɞ ˄˒˕I$şˁʲʿ ɓ ʽ˅jʫʥ˕ʜɄ
ɄɄ ̕ɗɗ &˅ĴBīʢÛƲ˅Ĵ˅Żƺīʣ˙%ʼʹżƉˀʛÁɄɄ Ʉ ƙ ɑɑ Â˅ơȎˀ ɓəɏɗɗ &˄ ɒ Ė˅ƽĴ˅ðǚʫ˘˖ʿʦʹɄɄ Ʉ ̘̚ɑɄɭʂɿʉʁɷɌɄɒɐɑɔ̙ʜɄɄ ̕ǘ¬ĒȢ˅ǥƝˆŒʦʫʛɑɖɗ &˅ÛƲ˙­ǳˁʲʹǬġˀʛĿūÿ˅ɄɄ Ʉ ˃ʪʼʹ ɘɕ &˅ ɖɎɖɇ˄ ɭɬɟ ʫˍ˓˖ʹ̘̚ɒɄɤʕʐɌɄɒɐɑɓ̙ʜɄɄ ̕ȺȣƓũ˙Ŀūʴ˕ˮ̔˰̖ˀ˅ ɑɖɗ e˅ÛƲǬġˀʛĿūćĒʫȞʭ˃˕ɄɄ Ʉ ˄ʽ˖ʿ ɭɬɟ ˅ȷÄˆʫ˔ʛƙ ɔɐɐ Ąˌˀǘ¬ˀʬʹ ɘɕ e˅ ɑɗɎəɇ˄ɄɄ Ʉ ˍ˓˖ʹʜ˃ʩ ɭɬɟ ˅ˍ˓˖ʹÛƲ˅ʧʻʛĖʫpc˅Q˄ĻʾʦʿɄɄ Ʉ ʦ˕Jcˆ ɒɘɎɖɇˀʥʼʹ̘̚ɓɄɭɻʈɻʐɌɄɒɐɑɒ̙ʜɄ
Ʉ̚ɑɄɭʂɿʉʁɷɄɟɱɌɄɻʊɄɷʂɎɄɧɄɠʂɿʄɄɰʂɻɻʆɄɪɻɺɌɄɑɕɚɄɑɒɘɕɍɑɒəɑɌɄɒɐɑɔɄ
̚ɒɄɤʕʐɄɤɎɄɧɄɬʈʅɼɷɹɄɬʈʊɾʅʆɌɄɒɘɌɄɧʋʄɻɄɒɘɌɄɒɐɑɓɄ
̚ɓɄɭɻʈɻʐɄɠɲɌɄɻʊɄɷʂɎɄɰʂɻɻʆɄɟʈɻɷʊɾɌɄɑɗɚɄɓɒɓɍɓɓɒɌɄɒɐɑɓɄɄɄ̛̤Ⱥ˙Hā˄ŖÈʴ˕ǎƫ˅(/ǘˁˍʛ˨˭˷˄ʽʦʿɄɄ ɬɞ ˁȺ˙Hā˄ƆOʱʶ˃ʦǎƫˌʹˆʛ̃̎ˮ̇ǎƫ˅(/ǘˁˍʛ˨˭˷˙óžʴ˕ʧʨˀʛˌʵ|˅ïşǭü<ˀȄˉ˓˖ʹˏ˅˙íʯ˕ʜ˃ʩȺ˙Hā˄ƆOʱʶ˃ʦǎƫˁˆ ɬɞ ˁdʳÍá˅ˏ˅ˀʛ̃̎ˮ̇ǎƫˁˆȺ˅˂ʻ
˓ʪʺʮ˄ǎŶʴ˕̃̎˭˲˳˥˅ĝ˅˒ʧ˃ˏ˅˙ʱʴʜɄ20ɄɄ Ʉ %şŗŀ˄ʽʦʿɄɄ ̕ɬɞ ƮˁȺ˙Hā˄ƆOʱʶ˃ʦǎƫƮ˅˿̎̑̐ǤȿʢǌȿƲʫ˂ʻ˓ʪɄɄ Ʉ ā˅ǎƫ˙%şʲʿʛʷ˅ȑʦ˙Ĥǜʴ˕żƉʣˀˆʛɬɞ ƮˁʛȺ˙HāɄɄ Ʉ ˄ƆOʱʶ˃ʦǎƫƮ˄ʩʮ˕ ɑ Ĉ˅ǎƫ˅%şŗŀˆʷ˖ʸ˖ɄɄ Ʉ ɗɎɗʑɐɎɕ ćȢʛɖɎɕʑɑɎɔ ćȢˁdƇÄˀʥʼʹɉɟʂɷʄɹʅɌɄɒɐɐɕɊʜɄɄ Ʉ ˅jˀˏdƇÄˀʥʼʹɉɡʋʈɷʄɍɠɷʄʊɷʂʂɷɌɄɒɐɑɕɊʜɄɄ ̕ɬɞ Ʈˁ̃̎ˮ̇ǎƫƮ˅˥̒˭ˡ̖˾̖Ǥȿˀˆʛɬɞ Ʈˁʛ̃̎ˮ̇Ʈ˄ɄɄ Ʉ ʩʮ˕ ɑ Ĉ˅ǎƫ˅%şŗŀˆʷ˖ʸ˖ ɖɎɘʑɐɎɑ ćȢʛɖɎəʑɐɎɑ ćȢˁɄɄ Ʉ dƇÄˀʥʼʹɉɤʅʊʉʅʆʅʋʂʅʉɌɄɒɐɐɔɊʜɄɄ Ʉ ˅jˀˏdƇÄˀʥʼʹɉɞɷʈɷɸɌɄɒɐɑɑɄ ʛɡɷʂɄɣɷɸɸʈʅɌɄɒɐɑɔɊʜɄ̕ɬɞ Ʈˁ̃̎ˮ̇ǎƫƮ˅˥̒˭ˡ̖˾̖Ǥȿˀˆʛɒɔ e ɒɑ e̘ɘɗɎɕ̗ɄɄ ʫ ɬɞ ˙ĹĈ%şʴ˕ʰˁʫˀʬʹɉɪɻɾʊɷɌɄɒɐɐɑɊʜɄ
Ʉ(/ǘˁˍ˄ʽʦʿɄ
̕ɬɞ %şƮ˅ ɒɔ e ɒɓ e̘əɖɎɐ̗̙ʫũŗ˅÷u˙ǧǯʲʹʰˁ˄˒˔ʛɬɞ ˅%ş˙ƣƤʴ˕ʰˁ˙½đʲʹɉɪɻɾʊɷɌɄɒɐɐɑɊʜɄ
Ʉ ̕Ŀū˄­ʴ˕ŋǼÄ˄ȣʲʿʛɬɞ Ʈˆ ɗɓ̗ʛ̃̎ˮ̇Ʈˆ ɑɑ̗ˀʥ˔ʛɄɬɞ Ʈ˅ ɘə̗ʛ̃̎ˮ̇Ʈ˅ ɕɒ̗ʫdʳǎƫˀ˅Ŀū˙ƣƤʴ˕ʰˁ˙½đʲʹʜ̘ɪɷʈʁʂʋʄɺɌɄɒɐɑɕ̙ʜɄ
ɄɄʰ˅ʛɬɞ ˅ÛƲŋǼÄ˄ȣʲʿʛɬɞ Ʈˁ̃̎ˮ̇Ʈ˙ĺȀʲʹjʫʥ˕ʜɬɞ
ƮˆˁʿˏŋǼʛŋǼʛŋʫʷ˖ʸ˖ ɔɑ̗ʛɕɕ̗ʛɔ̗ʛ̃̎ˮ̇Ʈˆ ɗ̗ʛɓɔ̗ʛ
ɕə̗ˀʥʼʹɉɤʅʊʉʅʆʅʋʂʅʉɌɄɒɐɐɔ ˅ȣȉǭü̦ɤʅʊʉʅʆʅʋʂʅʉɄɥɌɄɻʊɄɷʂɎɄ ɞʃɄɧɄɯɻʉʆɿʈɄɠʈɿʊɄ
ɠɷʈɻɄɪɻɺɌɄɑɖɖɚɄɗɔɓɍɗɔɘɌɄɒɐɐɒɊʜɄ
ɄĄĖŷŵĴƅˀH|$ãʲʹǡūˣ˞˸̎˞̔ˀˆʛǎƫ˅(/ǘˁˍ˄ȣʲʿ ɬɞ ˁơɂŮëƤȪliūŁ̘ɠɭɞɭ̙ˀĺȀ˙ǉʼʹʫʛʷ˅Ȭ˄óžʲʹĦǒ˙YƱ˄óžʴ˕ʜɄ̕Ʉ ɬɞ ˅ÛƲŋǼÄ˄ȣʲʿʛɠɭɞɭ ˁĺȀʲʹˏ˅ˀʛŋ˙̝ʛŋǼ˙ ɑɐ ˁʲʹ˭˧̖̐ǣ(ˀʛɬɞ ʫ ɗɎɖʑɑɎəʛɠɭɞɭ ʫ ɗɎɔʑɒɎɑ ˁʦʧjʫʥ˕̘ɥʅɻʁɻʃɷɌɄ Ʉɒɐɐɘ̦H|˅ǡūˣ˞˸̎˞̔˅ïşǭü̙ʜɄ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ Ʉ
̕%şȷÄ˄ȣʲʿʛ^ƹ<ǎƫˁ ɠɭɞɭ ˙ĺȀʲʹj̘ǝǋ̙ˀˆʛɬɞ ˅āʫȞʭ%şˀʬ˕3g˄ʥʼʹ̘ʦʵ˖ˏH|˅ǡūˣ˞˸̎˞̔˅ïşǭü̙ʜɄ
Ʉ

21

Ʉ
ɥʅɻʁɻʃɷʄɌɒɐɐɘɄ

ɩɷʃɌɒɐɐɗɄ

ɬɞɄɖɎə ćȢɄɖɎɔ ćȢɄɠɭɞɭɄɖɎɕ ćȢɄɔɎɒ ćȢɄɥʅɻʁɻʃɷʄɌɒɐɐɘɄ

ɩɷʃɌɒɐɐɗɄ

ɬɞɄɖɎɗ ĄɄɕɎɒ ĄɄ

ɠɭɞɭɄɖɎɗ ĄɄɔɎɔ ĄɄ

Ȣ˅%şćȢ˄ʽʦʿɄɑ ȊȢ˅%şĄû˄ʽʦʿɄ

Ʉ˙ˌˁˎ˕ˁʛƙ ɓ̗ƇÄ˄ ɬɞ ŕĐ˅I$ş̘ȺȣƓŪʛsņȎƏ̙ʫʥ˕ʜʲʪʲȺ˙Hā˄ƆOʱʶ˕ ɬɞ ˆȺ˙Hā˄ƆOʱʶ˃ʦǎƫˌʹˆ̃̎
ˮ̇ǎƫˁ ɑ Ĉ˅%şŗŀˆdƇÄˀʥʼʹʜɄ
Ŀū˄­ʴ˕ŋǼÄ˄ȣʲʿʛɬɞ Ʈˆ̃̎ˮ̇Ʈ˒˔ˏą˓ʪ˄ɀʭʛɬɞ Ŀū˅ƣƤ˙½đʴ˕āʫ̃̎ˮ̇Ʈ˒˔ˏʦʜʰ˅ʰˁʪ˓ʛĿūNĠ˅ɀʦ ɬɞ ĿūˆÛƲ˅ŋǼÄ˙ʯ˕ˁƱʨ˓˖ʹʜɄ
ɄɄ
Ŀū˄ʩʮ˕˨˭˷˄ʽʦʿɄ
Ⱥ˙Hā˄ƆOʱʶ˃ʦǎƫˆȈÀ˅ ɬɞ ˁˊˋd˅ǎƫ˅ʹˎʛ˨˭˷ˏ
ˊˋdȹˁƱʨʿƿʦʜH|˅ˣ˞˸̎˞̔˅Ȭ˄óžʲʹ˨˭˷˄ȣʴ˕<©˅Ħǒˆˀʥ˕ʜɄ
̕ɬɞ Ŀū˅Ƕş̘ɑɐ ÂȢʛɓ JǴè̙Ʉʩʩ˒ʷ əɕɌɐɐɐ̩ɑɕɕɌɐɐɐ =ƇÄʜ̘ʲʛ̝Â˄ƙ ɔ |˅Ȉȧˁʲʛ̞Âʩʬ˄ ɬɞ˙ĀǐʲʹcʜĴkŨƒŜːĤġǶşˆEȇʜ̙ɄɄ̕ʢYƱʣɄ ɠɭɞɭ Ŀū˅Ƕş̘ɑɐ ÂȢʛɓ JǴè̙Ʉʩʩ˒ʷ ɖɖɕɌɐɐɐ =ƇÄʜ̘ʲʛ̝Â˄ ɑɒ |˅ȈȧˁʲʛĤġǶşˆEȇʜ̙ɄɄɄ̛̥ɢʌɿɺɻʄɹɻɄʊʅɄɡɻɹɿʉɿʅʄ ˵̖̂̐ʛDÿ˅ǒƙʛƢǭɄɠɮɑɄ ʢȠØŷŵćŒliũÛƲ˄­ʲʿʛ^ƹ<ǎƫˆʛĐNʪʣɄɠɮɒɄ ʢȠØŷŵćŒliũÛƲ˄­ʲʿʛHāƆOȜ˅ʬʦ^ƹ<ǎƫˆʛHāƆOȜ˅¯ʱʦ^ƹ<ǎƫ˒˔ʛĐNʪʣɄ

22

ºBĪ
ėNtÄÂ®=:¼uãƘ]ƆƓŲ4ç!ìßƛŲ+žĪĪ]āǛuãǜĪ

Ǜ¦¾ǜĪ

ėNtÄÂ®=:¼uãĪ

ĪĪ

4ç!ìßŷĥƭ'Ê,ƄƊƍƥƚŸĪ

Ī

Ī

Ī
Ī

úĪ
Ī

$Ī

ǒƹǙƿƳǈǂǗƻĪ

âĪƃƚBģƛġ H!ƔJƓƮ-Ƅƫƍ4ç!ìßǛşšŒŜĪŒŠŠŜŚŒŞŔŖĽĪŌĿǜ¦¾ƭƈƈƤƪƃƕƛ ĪſĨźƔƈ
ėNtÄÂ®=:¼ǛşœŢţšŤŔţŚťŖĪŢŜŖŖŠĪŒŠŞŖŒĽĪŌŏĿǜuãƘ&ÀſPźƕ
žǢĪĪâżƪųƃƚĝŲ¬¿Ɨìßƚ|¨ƭÇƈqîſŹƪſŲĥƭ'ƘÊ,Ɔƍ4ç!ìßſnƘéź¦¾ƔŹƪžƭŲƤƓùƈƪƃƕſ
ůĪźźżĪ
B ůĪŽƋƨƁŲźźżĪ Fƚ×ÝƔŹƪųĪĪĪĪĪ
ģůĪŽƋƨƁŲƛźĪ
ŰƛźĪĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪ

wƄƫƪ+ƛQƀźƔƈžǢĪ

Ī+ůĪƬƉžĪ
ůĪ^ƄźĪ
ŰĪËhĪ
ůĪQƀźĪ
ĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪĪĪĪ
ŌŏĿ uãƚƍƤƚǊǑƼǌ ŌĿǛƸǗǃǕǙǓ ŌĿǜƕ£ĉƆƍ ŌĿǛƯƷǁưǉ ŌĿǜĪƯƲǃƵǎĪ

wƄƫƪÙ]+ĮĪǛļĸǚŁŇǜĪĪ
ƸǗǃǕǙǓ ŌĿĪîĪƯƷǁưǉ ŌĿĪ

0*ã

ƳǈǂǗƻ

ƚŮĪĪ

ƚĄĪ

ǛÅÌǜ

ǛŅŎĿłŃǜĪĪ

ƛŲĪĪ
ĿņŇĪĪ

ƸǗǃǕǙǓ ŌĿ ƚeJ ĿņŇ ƭ ĳĪ ƕƈƪƕĪƯƷǁưǉ ŌĿ ƚeJ ĿņŇƛ Ĵĳıļļ ƧƩƁƗƪǛĴĶıĹĴ
źĻıĶĹ źǜĪĪ]°ƧƩ ŌĿ àƚſŲÄÂ Ĵ ęŹƍƩƚŵ®=:Ŷƕŵ=:Ŷƚ
6õFǛĿņŇǜſźƍƤŲŌĿ àƚſÀųĪ

ĸķĳĪ ǛļĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪƚƸǗǃǕǙǓ ŌĿ ƚeJ ŏŠŌĵ ƭǞƕƈƪƕĪĪƯƷǁưǉ ŌĿ ƚeJ ŏŠŌĵ ƛ ĶıĵĶ ƧƩĨƁƗƪ
Ǜĵıĳļ ĨźķıĶĺ ĨźǜĪĪ

]°ƧƩ ŌĿ àƚſŲÄÂƚ
ĒÕĦ?hƚſĨźƍƤŲ
ŌĿ àƚſÀųĪĶļĹĪ ǛĸĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪ

ñēƱǗǂ
ǀƷƻĪĪ

ƸǗǃǕǙǓ ŌĿ ƚeJñēƭǞƕƈƪƕĪƯƷǁưǉ ŌĿ ƚeJñēƛ ļıĸĺ ƧƩƁƗƪǛĴĵıĺĻ źĹıĶĹ źǜĪĪ]°ƧƩ ŌĿ àƚſŲÄÂǟęnƍƩƚñē1rƚFſƈƪƍƤŲŌĿ àƚſÀųĪĶĸļĪ ǛĹĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪŃŏŏǛƳǊǖ
ǙƻÂ¤`hǜĪĪƸǗǃǕǙǓ ŌĿ ƚeJ ŃŏŏǛƳǊǖǙƻ
Â¤`hǜƭǞƕƈƪƕĪƯ Ʒ ǁ ư ǉ ŌĿ ƚ e J ŃŏŏǛƳǊǖǙƻÂ¤`hǜƛ Ĵıĵĸ ƧƩƁƗƪǛĵıļĸ źĳıķĹ ĨźǜĪĪ

ƚÂ¤ƭÇƈƳǊǖǙƻÂ¤`hĬŃŏŏĭƚƛŲ]°ƕ ŌĿ àƔxƗaƛƗžƐƍųĪ

ĵķĳĪ ǛķĪ ⨁Ī ű Ī űĪŎŁŐǜĪĪ űĪĠdƘĪĴĪ

ŏńİĶĹ ƚ²
µƸǗǍǙ
ǅǗǃĪĪ

ƸǗǃǕǙǓ ŌĿ ƚeJ ŏńİĶĹ ²µƸǗǍǙǅǗǃƭǞƕƈƪƕĪƯ Ʒ ǁ ư ǉ ŌĿ ƚ e J ŏńİĶĹ ²µƸǗǍǙǅǗǃƛ ĴıĴ ƧƩĨƁƗƪǛĵıĳĶ źķıĵĵ ĨźǜĪĪ

ć¿Ɨi`hĬŏńİĶĹĪōřŨŢŚŔŒŜĪ
ŁşŝŠşŞŖŞţĭƚƛŲ]°ƕ ŌĿ àƔƗaƛƗžƐƍųĪ

ĴķĶĪ ǛĵĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪŏńİĶĹ ÓÈ
ƸǗǍǙǅ
ǗǃĪĪ

ƸǗǃǕǙǓ ŌĿ ƚeJ ŏńİĶĹ ÓÈ¿ƸǗǍǙǅǗǃƭǞƕƈƪƕĪƯ Ʒ ǁ ư ǉ ŌĿ ƚ e J ŏńİĶĹ ÓÈƸǗǍǙǅǗǃƛ ĴıĴ ƧƩĨƁƗƪǛĵıĳĻ źķıĵĻ ĨźǜĪĪ

ÓÈ¿Ɨi`hĬŏńİĶĹĪŊŖŞţŒŜĪ
ŁşŝŠşŞŖŞţĭƚƛŲ]°ƕ ŌĿ àƔxƗaƛƗžƐƍųĪ

ĴķĶĪ ǛĵĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪĵķ ę2Þ ê IǛŝŝņŘ ƔǜĪĪƸǗǃǕǙǓ ŌĿ ƚeJ ĵķ ę2ÞêIǛŝŝņŘǜƭǞƕƈ
ƪƕĪĪĪƯƷǁưǉ ŌĿ ƚeJ ĵķ ę 2 Þ  ê I Ǜ ŝŝņŘƚ ǜ ƛ Ĵıĳĸ Ƨ Ʃ  Ɓ Ɨ ƪǛķıĵķ źĵıĴĸ ĨźǜĪĪĵķ ęƚ2ÞêIƚƛŲ]°ƕ ŌĿ àƔxƗaƛƗžƐƍųĪ

ĴĻĳĪ ǛĵĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪĵķ ęl ê IǛŝŝņŘ ƔǜĪĪƸǗǃǕǙǓ ŌĿ ƚeJ ĵķ ęlêIǛŝŝņŘǜƭǞƕƈ
ƪƕĪĪĪƯƷǁưǉ ŌĿ ƚeJ ĵķ ę  l  ê I Ǜ ŝŝņŘƚ ǜ ƛ ĴıĶķ Ƨ Ʃ  Ɓ Ɨ ƪǛĶıķĴ źĳıĺĶ ĨźǜĪĪĵķ ęƚlêIƚƛŲ]°ƕ ŌĿ àƔxƗaƛƗžƐƍųĪ

ĴĻĳĪ ǛĵĪ ⨁Ī⨁Ī⨁ĪűĪŎŁŐǜĪĪ ĪĴĪ ŏŠŌĵĪĪ

wƄƫƪZƛ^ƄźƔƈžǢĪ
ĪůĪQƀźĪ
ůĪÍhĪ
ŰĪ^ƄźĪ
ůĪƬƉžĪ
ĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪ

ĪZ

Ī

¦¾ƘƑźƓĪ Ī

ǘŌĿ àƕŲĥƭ'ƘÊ,ƄƊƗźìßàƔƛ
ìßƞƚuãƚ3ƂƫGğƦD¤ƘƧƪƘQƀƗaƛƗźǛŀŜŒŞŔşįĪĵĳĳĸŲĪōŖţšŚįĪĵĳĳĻǜųƍƎƆ ĴĲĶĵ ƔŹƪſŲĥĚÐ½ƔƆƍƥƚƛ
ŌĿ àƚƣƔŹƐƍǛōŖţšŚįĪĵĳĳĻǜųĪ
ǘŌĿ àƕǊǑƺǙǌìßàƚƷǕƻƴǙǆǙûħ
ƔƛŲŌĿ ƚ·ƘƧƩ ĴĲĶļ ſĥĚÐ½ƔƆƍǛłŒŜİńŒœœšşįĪ ĵĳĴķǜųŌĿ ƚ·ƘƧƩ ĴĲĵĻſA©čPƔŲĴĲĵĻ ſĥĚÐ½ƔƆƍǛŊŖřţŒįĪĵĳĳĴǜųĪ
¦¾ƭWØƆƓƚ(·ƘƑźƓĪ

ǘŌĿ àƔA©čPſ ĵĲĻ ƔƣƨƫƍſŲ'ƘÊ,ƄƊƗźìßàƔƛƣƨƫƗžƐƍ
ǛŀŜŒŞŔşįĪĵĳĳĸǜųĪ
ǘĔÑƗ(·ƕƆƓ5Ċ¿Ɨ@6ƚO-ſŌĿ àƚ ĸĲķĵ ƔƣƨƫŲĥƭ'ƘÊ,ƄƊƗźìßàƔƛƣƨƫƗžƐƍǛłŤšŒŞİŁŒŞţŒŜŜŒįĪ
ĵĳĴĸǜųĪ
ǘǊǑƺǙǌìßàƔƛ(·ƛ®źſŲŌĿ àƔƛągƚ¡ƚč¼³Ųągƚ@ÎđƚI½Ųągƚ@6ƚĎ?yŲA©čPŲ4ªyŲìÃƚEGğſƣƨƫƍǛĿŒšŒœįĪ ĵĳĴĴǜųƗ
Žƃƫƨƚ(·ƛŲźƉƫƥĈhžƨÍhƔŹƐƍǛŊŖřţŒįĪĵĳĳĴǜųĪ
ǘŃŏŏ ƘĚƆƓƚǏƽóƔŲİĴıĵĸŷİĵıļĸįĪ ĳıķĹŸƕ
ZƭâzƈƪØƭpƓźƪųĪ

¿ƗƳǈǂǗ {ƚƯƲǃƵǎƚÁ]¿ƗĔîtƢƍƛĽĪĪƻƚÆtƛƖƫ
ƯƲǃƵǎĪ
Á]¿ƗĔîtĪĪ
ƳǈǂǗƻƚÆYtĪĬŅŎĿłŃĭĪĪ
ƔƈžǢĪ
ĿņŇĪ
ĔQĪ
⨁⨁⨁űĪ
Ī
Ī

Ī

ŉşŦŖŢţĪŏŠŌĵĪ

ĔîĪ

⨁⨁⨁űĪ
Ī

ĿšşŤŢŒŜĪŇŞŕŖŧĪ

ĔîĪ

⨁⨁⨁űĪ
Ī

ŃŏŏĬŃŠŦşšţřĪŏŜŖŖŠŚŞŖŢŢĪŏŔŒŜŖĭĪ

ĔîĪ

⨁űűűĪ
ĠdƘĪ

ŏńİĶĹĪōřŨŢŚŔŒŜĪŁşŝŠşŞŖŞţĪ

ĔQĪ

⨁⨁⨁űĪ
Ī

ŏńİĶĹĪŊŖŞţŒŜĪŁşŝŠşŞŖŞţĪ

ĔQĪ

⨁⨁⨁űĪ
Ī

ĵķřĪŏŨŢţşŜŚŔĪœŜşşŕĪŠšŖŢŢŤšŖĪĬŝŝņŘĭĪ

ĔQĪ

⨁⨁⨁űĪ
Ī

ĵķřĪłŚŒŢţşŜŚŔĪœŜşşŕĪŠšŖŢŢŤšŖĪĬŝŝņŘĭĪ

ĔQĪ

⨁⨁⨁űĪ
Ī

Ī

Ƴ
ǈ
ǂ
Ǘ
ƻ
ƚ
Æ

t

ůĪĠdƘĪ
ůĪĪ
ŰĪĪ
ůĪĨĪ
Ī
ůĪÅÌƗƆĪ

Ī

Ī

Ī

Ư
Ʋ
ǃ
Ƶ
ǎ
Ƙ
]
ƈ
ƪ


ò

ŴſîƗƯƲ
ǃƵǎƭƖƚËh
ĔðƈƪžƘƑź
ƓĔîƗÆYt
ƛŹƪžǢĪ
ĪŰĪĔîƗÆYtƢƍƛƜƨƑƀ
ŹƩĪůĪĔîƗÆYtƢƍƛƜƨƑƀ
ƚ5åtŹƩĪ
ůĪĔîƗÆYtƢƍƛƜƨƑƀ
ƛŽƋƨƁƗƆĪ
ůĪĔîƗÆYtƢƍƛƜƨƑƀ
ƗƆĪÄÂ¡ÉVƚø¾ƶƱǄǑƱǗƚj·ǡŵ4ç!ìßƚ·ƭėNtÄÂ®=:¼àƚuãƘSƈƪųƍƎƆį×ĩ¿ĪÛĜI=:¾¨Ĭ  ŁōĿōĭſďrƕƗƪ¼ƘĚƆƓƛŲŁōĿō ƭďrƆŲŁōĿō ƭĪ·ƔƀƗźM6Ų4ç!ì
ßƚ·ſƢƆźųŶĬŅŎĿłŃĪĴŀĽmźSĲƳǈǂǗƻƚĄŵŶĭĪĪ ¸Ī FŲ
H!ƔĢ·ƆƓ·źƨƫƓźƪ4ç!ìßƘƤƓ¯­ƭŹƓöƆƍſŲƸƷĪǑ
ǗǔǈǐǙƛƇƤč/ƚǔǈǐǙŹƪźƛƶƱǄǑƱǗƕƄƫƪƥƚƕ7ƇSƘĪƗƐƍƃƕƛxáƔŹƐƍƕâżƪŷÄÂ4ç.VįĪĴįĪķİĵĺįĪĵĳĴķŸųĵĳĴĸ fƘL;ƄƫƍÒHÄÂVƕÒHÄÂ¡ÉVƚø¾ƶƱǄǑƱǗƘĚƆƓƥ7ƚSƕƗƐƓŽƩŷňŁŏŊįĪĴĴįĪĺĺĶİĻĵĺįĪĵĳĴĸŸŲH!ƚƠơÜƓƚ÷ſŲƃƚƧŻƗ4ç!ìßƚďrǛĈ¼Í¼ŲŋŒŢŒŜİŁōĿō ĞæãǜƘ¬ƆƓźƪųĈ¼ƕĔ¼Ɣ
ƛ7ƇƯƲǃƵǎƔŹƐƓƥŲƖƚËhƃƫƭĔðƈƪžſ¹ƗƪųĪƘŽƂƪ4ç!ìßƚ¦¾ƚďrƛĈ
¼Í¼ŲƢƍ ŋŒŢŒŜİŁōĿō ¾¨ƚĞæãŲƔŹƪƃƕƚƸǗƼǗƹƻƛpƨƫƓź
ƪųĔ¼Ɣƚ¦¾xáƘ¶>oƚsƛ9ƢƫƪſŲĈ¼ƔƛqƉƆƥƋŻƔƗ
źųĪĪĖ·ƘŻè¡đƚĘ@ǛōşŢţŖšŚşšĪ şŠŖŞĪ œŚţŖǡōŌŀǜƘƑźƓǡĪ ĺĺ ƚ¡# ƸƻǃƘƑźƓ ǡĪ ĥƭ'ƘÊ,ƄƊƗź+ƕZƚǆǑǗ
KƭƐƍÅÌƔŲeJÔ ĴĴ fƚ×čƔ ĶļĲĺĺ Ƙ ĵ  ƚè¡ƚĥ ìßƛČdƚ ŌĿ ƕƠơ7KƚìßƚƍƤŲ
ƻƛƖƏƨƚ¦¾ ƚôſRƬƫƓźƍǛǝĴĪ ōŜŚŢśŒįĪ ĵĳĴķǜųǘò\ęƚüÖƛ®źſŲĴĹĺ ƚu ƸƻǃƥƠơ7ĤƕâżƓéźųƢƍǊǑƺǙ
ƭƆƢƈžǢĪ

ãƭ]āƕƆƍþƔŲ¦¾ƚƗžƐƍ Ļĸ ƚ ĹıĹīƘ ōŌŀ ſƣƨƫƍǛǝĵĪ ǌìßƛ±ĥŷĥƢƍƛĥƚƖƏƨžŸ
ůĪ]°ƭƈƪĪ ŅūũįĪ ĵĳĴĶǜųǘĴĹĺ 8ƚuãþƔŲ¦¾ſĖƁƗƪƘƑƫƓ ōŌŀ ƚĢhƛ ƘìÃƈƪƥƚƔŲŌĿ ƧƩƥă·ƛ_ƗźųĪſƩŲÔ ķĳĳ ƢƔò\Ɣƀƍ Ļĸ 8ƚ ĴĺıļīƘƣƨƫƍųƗŽ ōŌŀ ƚƣƨƫƍuã
ůĪŽƋƨƁ]°ƭƚŻƏŲ ſ@6ƚO-Ƙ¤ƒźƓźƪ)6ƛ ĵĻıĹīƔŹƐƍǛǝĶĪōŖšŖũįĪĵĳĴĵǜų
ƈƪĪǝĴĪōŜŚŢśŒĪŀŐįĪŖţĪŒŜıĪňĪŁŜŚŞĪŏŜŖŖŠĪŊŖŕįĪĴĸĽĪĴĵĻĸİĴĵļĴįĪĵĳĴķĪ Ī ǝĵĪŅūũĪŅıĪňĪŌšşŗŒŔĪ
ůĪƖƏƨƥƆƗźĪŌšţřşŠįĪĵĻįĪňŤŞŖĪĵĻįĪĵĳĴĶĪ Ī ǝĶĪōŖšŖũĪŁőįĪŖţĪŒŜıĪŏŜŖŖŠĪŀšŖŒţřįĪĴĺĽĪĶĵĶİĶĶĵįĪĵĳĴĶĪ
Ī

Ī

+

ƚ
ǆ
Ǒ
Ǘ ŰĪŽƋƨƁ Ǜ¦ƻ ¾ǜƭƈƪĪ'Fƚø¾ƶƱǄǑƱǗƚĝƘ ÇƆƍƸƻǃƘĚƈƪ![ƚîǡĪ 4ç!ìßƚů Ǜ¦¾ǜƭƈƪĪĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪ

¦¾ƚă·ǛĴĳ fęŲĶ )Ă~ǜĪ ŽŽƧƋ ļĸįĳĳĳǣĴĸĸįĳĳĳ "ËhųǛƆŲǟfƘ
Ô ķ FƚČěƕƆŲǠfŽƀƘìßƭíƆƍM6ų¡<»ÏµƦă·ƛ%ċųǜĪĪ
·³§ƘƑźƓĪ
ƋƚĐ}äƛîƗƻǁǙƷǋǓ ǘŌĿ àƕĥƭ'ƘÊ,ƄƊƗźìßàƚǇǑǔǓûħƔƛŲŌĿĪàƕǊǑƺǙ Ī
ƾǙƘ3ƂƫƨǌàƘŽƂƪ ĴĪƚìßƚ·³§ƛƋƫƌƫ ĺıĺĪŪĪĳıĸĪęŲĹıĸĪŪĪĴıķĪęƫƢƈžǢĪ
ƕ7ËhƔŹƐƍĬŀŜŒŞŔşįĪĵĳĳĸǜĪų ƚL;Ɣƥ7ËhƔŹƐƍĬłŤšŒŞįĪĵĳĴĸǜųĪ
Ī

Ī

3
Ƃ

ƫ

ůĪ3ƂƫƨƫƗ
źĪůĪƍƝƮ3ƂƫƨƫƗźĪŰĪƍƝƮ3ƂƫƨƫƪĪůĪ3ƂƫƨƫƪĪ
ĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪ
Ī

ǘŌĿ àƕǊǑƺǙǌìßàƚƷǕƻƴǙǆǙûħƔƛŲŌĿĪàƕǊǑƺǙǌàƘŽƂƪ ĴĪƚìßƚ·³§ƛƋƫƌƫ ĹıĻĪŪĪĳıĴĪęŲĹıļĪŪĪĳıĴĪęƕ7ËhƔŹ Ɛ ƍ ĬŅşţŢşŠşŤŜşŢįĪ ĵĳĳķ ǜ Ī ų ƚ L ; Ɣ ƥ 7 Ë h Ɣ Ź Ɛ ƍ Ǜ ĿŒšŒœįĪĵĳĴĴ Ų łŒŜĪńŒœœšşįĪĵĳĴķǜųĪ
ǘŌĿ àƕǊǑƺǙǌìßàƚƷǕƻƴǙǆǙûħƔƛŲĵķĪ8 ĵĴĪ8ǛĻĺıĸĪǚſ
ŌĿĪƭ¢·ƈƪƃƕſƔƀƍĬŊŖřţŒįĪĵĳĳĴǜųĪ
òƕTƣƘƑźƓĪ

ǘŌĿ ·àƚ ĵķ 8 ĵĶ 8ǛļĹıĳǚǜſ¼³ƚCƭýĀƆƍƃƕƘƧƩŲŌĿ ƚ·ƭÚÛƈƪƃƕƭbƆƍĬŊŖřţŒįĪĵĳĳĴĭųĪ
ǘ¦¾Ƙ]ƈƪ«ĆhƘĚƆƓŲŌĿ àƛ ĺĶǚŲǊǑƼǌàƛ ĴĴǚƔŹƐƍųŌĿ àƕǊǑƼǌàƚƸǗǊǑƱƯǗƻƛƋƫƌƫĨƁŲŌĿ ƚ ĻļǚŲǊǑƼǌƚ ĸĵǚſ7ƇìßƔƚ¦¾ƭÚÛƈƪƃƕƭbƆƍųǛŊŒšśŜŤŞŕįĪĵĳĴĸǜųĪ
ƋƚĐ}äƭƕƪ
ƃƕƛ´Y¿Ƙ5åƔƈžǢĪ

Ī

Y
´
5
å
t

ůĪGğĪ
ůĪƍƝƮGğĪ
ůĪƍƝƮ5åĪŰĪ5åĪĪůĪƄƢƅƢƔŹƪĪ
ůĪƬžƨƗźĪ
Ī

Ī
Ī
Ī
Ī

uãƚ4ç!ìß¦¾ƚĐ}ƚYë5åtƘƑźƓǡĪ 4ç!ìß¦¾ƛ ĪėNtÄÂ®=:¼ƭøƈƪ.cƘƧƐƓŲ¦¾ĕſ¥XƄƫƪųƋ
ƚĝƘŲuãƦ¦¾~nƈƪ¡É.cƚxïƥ1ƄƫƪųŋŒŢŒŜİŁōĿō ƚÚÛ·ƘĚƆƓƛuãƸǗǊǑƱƯǗƻƘƥUƙƨƫƓźƪųĪ

ĪĪ$ƚîÔĪ
$Ī

Ī
BĪ ģĪ

źźżĪ

ŽƋƨƁŲźźżĪ

ŽƋƨƁŲƛźĪ

ƛźĪ

+Ī

ƬƉžĪ

^ƄźĪ

ÍhĪ

QƀźĪ

ZĪ

QƀźĪ

ÍhĪ

^ƄźĪ

ƬƉžĪ

ĠdƘźĪ

Ī

Ī

ĨĪ

òĪ

ĔîƗÆYtƢ
ƍƛƜƨƑƀŹƩĪ
ĪĔîƗÆYtƢƍƛƜƨƑƀƚ
5åtŹƩĪ

ĔîƗÆYtƢƍƛƜƨƑƀƛ
ŽƋƨƁƗƆĪ

ĔîƗÆYtƢƍƛƜƨƑƀƗ
ƆĪ+ƚǆǑǗƻĪ

]°ƭƈƪĪ

ŽƋƨƁ]°ƭƈƪĪƖƏƨƥƆƗźĪŽƋƨƁ Ǜ¦
¾ǜƭƈƪĪ

3ƂƫĪ3ƂƫƨƫƗźĪ

ƍƝƮ3ƂƫƨƫƗźĪ

ƍƝƮ3ƂƫƨƫƪĪ

3ƂƫƨƫƪĪ

Y´5åtĪ

GğĪƍƝƮGğĪ

ƍƝƮ5åĪ

5åĪƳǈǂǗƻƚÆtĪƯƲǃƵǎƘ]ƈƪ

Ī
Ī

Ī
Ī
Ī
Ī
Ī
Ī
Ī
Ī
Ī
Ī
Ī

5åtſŹƪĔîtĪ

Ī
Ī
Ī
Ī

ƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

ĪƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

ĪƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

Ī

ÅÌƗƆĪ

Ī

Ī

Ī
Ī

Ī

Ī

Ǜ¦¾ǜƭƈƪĪƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

ƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

ƄƢƅƢƔŹƪĪ

ƬžƨƗźĪ

Ī
Ī

Ī

Ī

Ī

Ī
Ī

ØÿĪ
Ī
ėNtÄÂ®=:¼àuãƘ]ƆƓŲ4ç!ìßƭŻƟƀžľĪ
ĪSƚƽƱǊĪ

ƃƚĐ}äƛSƔƀƗźĪƃƚĐ}äƭ·ƆƗźƃƕƭ ƈƪĪ

ůĪĪ

ůĪĪ

ƃƚĐ}äƭ·ƈ ƃƚĐ}äƭ·ƈƪƃƕƥ·ƆƗźƃƪƃƕƭ ƈƪĪƕƥŲƭ ƈƪĪ
ůĪĪ

ŰĪĪ

ƃƚĐ}äƭSƈƪĪ

ůĪĪ

Ī

SĪ

ėNtÄÂ®=:¼àuãƘŽźƓŲ4ç!ìßƔ¦¾ƭëŻƃƕƭkƁSƈƪųǛĪ ŅŎĿłŃĪ ĵŀǡkźSĪĲĪƳǈǂǗƻƚĄŬŭĪǜĪSƚÿĪ

SƚÿǡĐ}ƄƫƍƯƲǃƵǎƛÍhƚƳǈǂǗƻƚĄƘŽźƓŲĿņŇ ƘĚƆƓ4ç!ìßſÀƔŹƐƍųƃƚvLƘƧƐƓŲPƁƚuãƛƃƚ¦¾ƭĐ}ƈƪƕâżƪųƍƎƆ ĿņŇ ƕźŻƯƲǃƵǎƭƖ
ƚËhĔðƈƪžƘƑźƓƛuãƚĔ¼hƔ¹ƗƩŲkźSƕƆƍųĪ

Ī
Ī

©AĒ
ÿLl²±<9«mÏſYŭźř'¸,üƁOŧš3Ó!×ËƂř'¸,üƁZūš3Ó!×ËƎƐř+ťĒYëƹmÏƺĒ

ƹ­ƺĒ

ÿLl²±<9«mÏĒĒ

3Ó!×ËŞčƔ'¸,ūűŴƌƁşĒ

Ē

Ē
Ē

Ē

äĒ
Ē

$Ē

ƲƞƸƤƙƫƦƶƠĒ

ÎĒ

E!ŻHźƕ-ūƒŴ3Ó!×ËƹņňĺŃĒ ĺŇŇŃŁĺŅļľĥĒ Ĵħƺ­ƔůůƋƑŪżƂÿ ĖĒ¦çƿħĽŌĺŅļľĽĒĴħ żƂ'¸,ü

Ē

A
ċ

Ē

+


ŪƁAċƂLl²±<9«ƹņĻŉŊňŋļŊŁŌľĒ ŉŃľľŇĒ ĺŇŅľĺĥĒ ĴķħƺmÏſ&¯ŦNšżÎţ ƁOŧš Ĵħ ƁŪżŻřĳņŅĒħĽŌĺŅļľĽĒ
ĉŦĐšŻů
ƑŚŪƁąř®ž×ËƁsƔµůiÙŦŠƑŦř£GĊ¦ūƒźšƑ Ĵħ żƂ'¸,üƁZūš Ĵħ ƁŪťǀĒčƔ'ſ¸,ŭŴ3Ó!×ËŦfſÕš­ŻŠƑťƔř|ƋźãůƑ żŻŠƑŚĒ
ŖĒššţĒ
ŖĒŤŲƏŨřšš ŪżŦ CƁÄÊŻŠƑŚĒĒ
ţĒŖĒŤŲƏŨřƂšĒ
ŗĒƂšĒĒŖĒūƉŬƉŻŠƑĒ
ŖƓťƏžšĒ
oūƒƑ+ƂOŧšŻů
ťǀĒŖĒƓŰťĒ
ŖĒZūšĒ
ŗĒ¹aĒ
ŖĒOŧšĒ
ĒŖĒūƉŬƉŻŠƑĒ
ŖĒƓťƏžšĒĒĒĴķħ mÏƁŴƋƁĒĳņŅĒħĽŌĺŅļľĒĴħĒżñŭŴĒħĽŌĺŅļľĒĴħĒ
ƖƘƧƚƯĒ

oūƒƑÆY+ĖĒĔĤĠēĒĩįĕĒĒ

ÙĒ

ŕĒ0

ƙƫƦƶ

*ÏƁĒĒ ƠƁîĒĳņŅĒħĽŌĺŅļľĒĴħĒ

ħĽŌĺŅļľĒĴħĒ

ħĮįĒĒĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_
HĒħĮįĒƔƼżůƑżĒ

ħĽŌĺŅļľĒ Ĵħ Ɓ_HĒ ħĮį čƔ'ſ¸,ūűžš×ËƎƐřƂĒ ĢęĤğĒ ƎƐŨžƑĒ ĔĜĠęĠĝĒ čƔ'ſ¸,ūűŴ×ËƁŦřšěęĞġ šĕĒĒ²± Ĝ āŠŴƐƁŜ<9ŝżŜ<
9ŝƁ5ßC}ƹħĮįĕŦšŴƋřĴħ
ÌƁŦ¯ŚĒĜğğĒ ĔĞĒ ⨁⨁⨁ ŘĒĶĩĸĕĒĒ
ĒĜĒıņōľŉŊĒķŇĴĝĒĒ

ĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_HĒ ŃņōľŉŊĒ ķŇĴĝĒ ƔƼħĽŌĺŅļľĒ Ĵħ Ɓ _ H ĒĒ ²±ƁùÂĎ>aƁƂřŃņōľŉŊĒķŇĴĝ ƂĒĝęğĒƎƐĐŨ čƔ'ſ¸,ūűžš×ËżřčĢĢĒ ĔĜĒ ⨁⨁ŘŘĒĶĩĸĕĒĒĒĜĒĔ³ºĕĒĒ

ĔĭĶħĪīĕĒĒ

oūƒƑVƂ
ZūšŻůťǀĒ

żůƑżĒžƑĒ ĔěęğğĒ šĒ Ġęĝğ ĐšĕĒĒħňņŋŉĺŃĒįŅĽľŎĒĒ

ĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_
HĒĺňņŋŉĺŃĒįŅĽľŎĒƔƼ
żůƑżĒħĽŌĺŅļľĒ Ĵħ Ɓ _ H ĒĒ čƔ'ſ¸,ūűžš×ËƎƐřĺňņŋŉĺŃĒįŅĽľŎ ƂĒĤęĜĝĒƎƐ čƔ'ſ¸,ūűŴ×ËƁŦřŨžƑĒĔĜĞęĤġ šĒğęĝģĒ ²±ƽāfŴƐƁÜú1jƁC}Ŧ
šĕĒĒšŴƋřĴħ ÌƁŦ¯ŚĒĤĝĒ ĔĝĒ ⨁⨁⨁ ŘĒĶĩĸĕĒĒ
ĒĜĒīķķĔīŇōņňŊŀĒķŃľľŇŁŅľŉŉĒ
ķļĺŃľĕĒĒ

ĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_H  īķķĔīŇōņňŊŀĒķŃľľŇŁŅľŉŉĒ ķļĺŃľĕĒ ƔƼżůƑżĒħĽŌĺŅļľĒ Ĵħ Ɓ _ H ĒīķķĔīŇōņňŊŀĒķŃľľŇŁŅľŉŉĒ
ķļĺŃľĕ Ƃ Ē ĜęĝĒ Ǝ Ɛ  Ũ ž ƑĒĔĞęĠĜ šĒĒĜęĜĜĒĐšĕĒĒ

Ɓ±ƔµůƙƬƵƸƠ±[aĔīķķĕƁƂřčƔ'ſ¸,ūűžš×ËżřčƔ'ſ¸,ūűŴ×ËŻpž\ƂžťŷŴŚĒĠĝĒ ĔĜĒ ⨁⨁ŘŘĒĶĩĸĕĒĒ
ĒĜĒķĬĘĞġĒ ĵŀŏŉŁļĺŃĒ ĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_ĩņńŇņŅľŅŊĒĒ
H  Ē ķĬĘĞġĒ ĵŀŏŉŁļĺŃĒ
ĩņńŇņŅľŅŊĒ ƔƼżůƑ
żĒħĽŌĺŅļľĒ Ĵħ Ɓ_HĒ ķĬĘĞġĒ ĵŀŏŉŁļĺŃĒ ĩņńŇņŅľŅŊ ƂĒĜĒ ƎƐŨžƑĒ ĔġęĞĞ šĒğęĞĞĒĐšĕĒĒ

ï®žb[aĔķĬĘĞġĒĵŀŏŉŁļĺŃĒ
ĩņńŇņŅľŅŊĕƁƂřčƔ'ſ¸,ūűžš×ËżřčƔ'ſ¸,ūűŴ×ËŻpž\ƂžťŷŴŚĒĠĝĒ ĔĜĒ ⨁⨁ŘŘĒĶĩĸĕĒĒ
ĒĜĒķĬĘĞġĒ ĲľŅŊĺŃĒ ĳņŅĒ ħĽŌĺŅļľĒ Ĵħ Ɓ_ĩņńŇņŅľŅŊĒĒ
H  Ē ķĬĘĞġĒ ĲľŅŊĺŃĒ
ĩņńŇņŅľŅŊĒ ƔƼżůƑ
żĒħĽŌĺŅļľĒ Ĵħ Ɓ_HĒ ķĬĘĞġĒ ĲľŅŊĺŃĒ ĩņńŇņŅľŅŊ ƂĒĜęĞĒ ƎƐĐŨžƑĒ ĔĞęĝ šĒĠęģĒĐšĕĒĒ

À¶®žb[aĔķĬĘĞġĒĲľŅŊĺŃĒ
ĩņńŇņŅľŅŊĕƁƂřčƔ'ſ¸,ūűžš×ËżřčƔ'ſ¸,ūűŴ×ËŻpž\ƂžťŷŴŚĒĠĝĒ ĔĜĒ ⨁⨁ŘŘĒĶĩĸĕĒĒ
ĒĜĒ

Ē

Ē

V

ŖĒOŧšĒ
ŖĒ»aĒ
ŗĒZūšĒ
ŖĒƓŰťĒ
ĒŖĒūƉŬƉŻŠƑĒ
ŖĒƓťƏžšĒ

Ɣ'ſ¸,ūűŴ×ËŻpž\ƂžťŷŴŚĒƷĴħ ÌżřčƔ'ſ¸,ūűžš×ËÌ
ŻƂ×ËƅƁmÏƁ2ũƒDćƍBſƎƑſOŧž\ƂžšƹĨŃĺŅļņėĒ ĝěěĠřĒ ĵľŊňŁėĒ
ĝěěģƺŚŴŵŭ ĜĚĞĝ ŻŠƑŦřčĂ½¬Ż ŭ Ŵ ƌ Ɓ Ƃ Ĵħ Ì Ɓ Ɗ Ż Š ŷ Ŵ ƹ ĵľŊňŁėĒ
ĝěěģƺŚĒƷĴħ ÌŻ@õNŦ ĝĚģ ŻƊƏƒŴŦř'ſ¸,ūűžš×ËÌŻƂƊƏƒžťŷŴ
ƹĨŃĺŅļņėĒĝěěĠƺŚĒ
Ʒû¾ž(¦żŭź4ò®ž?5ƁMŦ Ĵħ ÌƁ ĠĚğĝ ŻƊƏƒřčƔ'ſ¸,ūűžš×ËÌŻƂƊƏƒžťŷŴƹĪŋňĺŅĘ
ĩĺŅŊĺŃŃĺėĒĝěĜĠƺŚĒ

ĒƷīķķ ſĂŭź ĵľŊňŁėĒ ĝěěģ ƁÅŻřĘĜęĝěŞĘ
ĞęĠĜėĒĜęĜĜşżVƔÎqůƑÅƔhźšƑŚĒ

ĒrƁƖƘƧƚƯƁ°Y®žûÙlƉŴƂĥĒĒĒƖƘƧƚƯĒ

Ē

°Y®žûÙlĒĒ

ĒĒƙƫƦƶƠƁ´UlĒĔĭĶħĪīĕĒĒ

ħĮįĒ

ûOĒ

⨁⨁⨁ŘĒ
Ē

ıņōľŉŊĒķŇĴĝĒ

ûÙĒ

⨁⨁ŘŘĒ
Ē

ħňņŋŉĺŃĒįŅĽľŎĒ

ûÙĒ

⨁⨁⨁ŘĒ
Ē

īķķĔīŇōņňŊŀĒķŃľľŇŁŅľŉŉĒķļĺŃľĕĒ

ûÙĒ

⨁⨁ŘŘĒ
Ē

ķĬĘĞġĒĵŀŏŉŁļĺŃĒĩņńŇņŅľŅŊĒ

ûOĒ

⨁⨁ŘŘĒ
Ē

ķĬĘĞġĒĲľŅŊĺŃĒĩņńŇņŅľŅŊĒ

ûOĒ

⨁⨁ŘŘĒ
Ē

Ē

ƙ
ƫ
Ʀ
ƶ
Ơ
Ɓ
´

l

®žƙƫƦƶƠƁ´lƂ
ŽƒŻůťǀĒ
ĒŖĒĈ^ſĒ
ŖĒĒ
ŗĒĒ
ŖĒĐĒ
Ē
ŖĒ³ºžŭĒ

Ē

Ɩ
Ƙ
Ƨ
ƚ
Ư
ſ
Y
ů
Ƒ


Ý

śŦÙžƖ
ƘƧƚƯƔŽƁ¹aûÛůƑťſ
ŸšźûÙž´UlƂŠƑ
ťǀĒĒŗĒûÙž´UlƉŴƂƃƏŸŧ
ŠƐĒŖĒûÙž´UlƉŴƂƃƏŸŧ
Ɓ4ÑlŠƐĒ
ŖĒûÙž´UlƉŴƂƃƏŸŧ
ƂŤŲƏŨžŭĒ
ŖĒûÙž´UlƉŴƂƃƏŸŧ
žŭĒ

²±·SƁâ­ƛƗƨƱƗƶƁc¦ƿŜ3Ó!×ËƁ¦ƔÿLl²±<
9«ÌƁmÏſyQůƑŚŴŵŭėÄđ®wĒÈĄF<9­Ĕ  ĩĵħĵĕŦöjżž
Ƒ«ſĂŭźƂřĩĵħĵ Ɣöjŭřĩĵħĵ ƔĒ¦ŻŧžšK5ř3Ó!×ËƁ¦ŦƉŭšŚŝĔĭĶħĪīĒĜĨĥešyQĚƙƫƦƶƠƁîŜŝĕĒĒ §Ē CřE!ŻĊ¦ŭź¦šƏƒźšƑ3Ó!×Ëſ|Ƌź ƔŠźàŭŴŦřƝƜĒƱƶƴƫưƸƂŮƋõ/ƁƴƫưƸŠƑšƂƛƗƨƱƗƶżūƒƑƌƁż6ŮyQ~ſĒžŷŴŪżƂpÍŻŠŷŴż
ÎţƑŚŞ²±3Ó.SėĒĜėĒğĘĝĢėĒĝěĜğşĝěĜĠ `ſJ:ūƒŴ¿E²±Sż¿E²±
·SƁâ­ƛƗƨƱƗƶſĂŭźƌ6ƁyQżžŷźŤƐŞİĩķĲėĒĜĜėĒĢĢĞĘģĝĢėĒ
ĝěĜĠşřE!ƁƇƈÉźƁáŦřŪƁƎŢž3Ó!×ËƁöjƹð«»«řĳĺŉĺŃĘ
ĩĵħĵ ĆÒÏƺſvŭźšƑŚð«żû«ŻƂ6ŮƖƘƧƚƯŻŠŷźƌřŽƁ¹aŪƒƔûÛůƑťŦ¨žƑŚĒſŤũƑ3Ó!×ËƁ­ƁöjƂð«»«řƉŴ ĳĺŉĺŃĘĩĵħĵ ­ƁĆÒÏřŻŠƑŪżƁƝƶơƶƞƠƂhƏ
ƒźšƑŚû«ŻƁ­pÍſ¥=gƁkƂ8ƉƒƑŦřð«ŻƂiŰŭƌŲŢŻžšŚĒ
Ēþ¦ſŢÔøƁĀ?ƹĵņŉŊľňŁņňĒņŇľŅĒĻŁŊľƿĵĴĨƺſŸšźƿĒ ĢĢ Ɓ#IƔ ƝƠƧſŸšźƿĒ čƔ'ſ¸,ūűžŷŴ³ºŻř_HÁ ĜĜ `ƁÄõŻ ĞĤĚĢĢ ſ ĝ  ƁÔƁčƁxÞŦP š×ËƂô^Ɓ Ĵħ żƇƈ6IƁ×ËƁ
ƓƒźšŴƹƻĜĒ ĵŃŁŉłĺėĒ ĝěĜğƺŚƷÝXāƁæÃƂšŦřĜġĢ ƁmÏƔYëżŭŴ ŴƋřƝƠƧƌƇƈ6ČżÎţźÕšŚĒ
éŻř­ƁžťŷŴ ģĠ Ɓ ġęġēſ ĵĴĨ ŦƊƏƒŴƹƻĝĒ ĭŒŐėĒ ĝěĜĞƺŚƷĜġĢ 7ƁmÏéŻř­ŦþŨžƑſŸƒź ĵĴĨ ƁĊaƂŦƐřÁ ğěě ƉŻÝXĒŖĒY¡Ɣ{wů ŻŧŴ ģĠ 7Ɓ ĜĢęĤēſƊƏƒŴŚžŤ ĵĴĨ ƁƊƏƒŴmÏƁŢŶř Ŧ?5ƁMſŹšźšƑ)5Ƃ ĝģęġēŻŠŷŴƹƻĞĒ ĵľňľŐėĒ ĝěĜĝƺŚƻĜĒ ĵŃŁŉłĺĒ ĨĸėĒ ľŊĒ ĺŃęĒ İĒ ĩŃŁŅĒ
ƑĒŖĒŤŲƏŨY¡Ɣ ķŃľľŇĒĲľĽėĒĜĠĥĒĜĝģĠĘĜĝĤĜėĒĝěĜğĒ Ē ƻĝĒĭŒŐĒĭęĒİĒĴňņĿĺļĒĴňŊŀņŇėĒĝģėĒİŋŅľĒĝģėĒĝěĜĞĒ Ē ƻ{wůƑĒĞĒĵľňľŐĒĩĹėĒľŊĒĺŃęĒķŃľľŇĒĨňľĺŊŀėĒĜĢĥĒĞĝĞĘĞĞĝėĒĝěĜĞĒ
+żVƁƩƱ
ƶƠƂŽŶƏƁ
­Ɣ{wŭƉ
ůťǀĒ

Ē

+

Ɓ
Ʃ ŖĒŽŶƏƌ{wŭƱ žšĒ'CƁâ­ƛƗƨƱƗƶƁąſzµŭŴƝƠƧſĂůƑ!WƁÙƿĒ 3Ó!×ËƁ­ƶƠ ŗĒŤŲƏŨ  Ɓí¦ƹĜě `āřĞ )ìuƺĒ ŤŤƎŲ ĤĠėěěěǁĜĠĠėěěě "¹aŚƹŭřƽ`ſÁ ğ CƁƹ­ƺƔ{wůôăżŭřƾ`Ťŧſ×ËƔØŭŴK5Ś;ª¼¤ƍí¦Ƃ%óŚƺĒƑĒŖ ƹ­ƺƔ{wůƑĒĒŖĒūƉŬƉŻŠƑĒ
ŖĒƓťƏžšĒ

Ē¦¢ſŸšźĒ
ŲƁ÷tÐƂÙžƠƥƸƜƭƷĴħ ÌżčƔ'ſ¸,ūűžš×ËÌƁƪƱƴƳåďŻƂřĴħ ÌżƬƱƟƸƮÌ
ƳƣƸſ2ũſŤũƑ Ĝ Ɓ×ËƁ¦¢ƂŲƒųƒ ĢęĢőěęĠ āřġęĠőĜęğ āż6¹aŻƒƏƒƉůťǀĒ
ŠŷŴĔĨŃĺŅļņėĒĝěěĠĕŚ ƁJ:Żƌ6¹aŻŠŷŴĔĪŋňĺŅėĒĝěĜĠĕŚĒ
Ē

Ē

2
ũ

ƒ

ŖĒ2ũƒƏƒ
žšĒŖĒŴƄƕ2ũƒƏƒžšĒ
ŖĒŴƄƕ2ũƒƏƒƑĒŗĒ2ũƒƏƒ
ƑĒĒŖĒūƉŬƉŻŠƑĒ
ŖĒƓťƏžšĒ
Ē

Ē

U
£
4
Ñ
l

Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē
Ē

mÏƁ3Ó!×Ë­Ɓ÷tƁUÖ4ÑlſŸšźƿĒ 3Ó!×Ë­ƂÿLl²± ĒŲƁ÷tÐƔż <9«ƔâůƑ.]ſƎŷźř­ýŦTūƒƑŚŲƁąſřmÏƍ­ufůƑƑŪżƂ£U®
·.]ƁpÚƌ1 ūƒƑŚĳĺŉĺŃĘĩĵħĵ ƁÇÈ¦ſĂŭźƂmÏƝƶƬƱƗƖƶƠſƌR
ſ4ÑŻůťǀĒ ƀƏƒźšƑŚĒ
ŖĒDćĒŖĒŴƄƕDćĒ
ŖĒŴƄƕ4ÑĒŗĒĒ4ÑĒ
ĒŖĒūƉŬƉŻŠƑĒ
ŖĒƓťƏžšĒ

$ƁÙÁĒ
$Ē

Ē
AĒ ċĒ

ššţĒ

ŤŲƏŨřššţĒ

ŤŲƏŨřƂšĒ

ƂšĒ

+Ē

ƓŰťĒ

ZūšĒ

»aĒ

OŧšĒ

VĒ

OŧšĒ

»aĒ

ZūšĒ

ƓŰťĒ

Ĉ^ſšĒĒĒĐĒûÙž´UlƉ
ƖƘƧƚƯſYůƑŴƂƃƏŸŧŠƐĒÝĒĒûÙž´UlƉŴƂƃƏŸŧƁ
4ÑlŠƐĒûÙž´UlƉŴƂƃƏŸŧƂ
ŤŲƏŨžŭĒûÙž´UlƉŴƂƃƏŸŧž
ŭĒ+ƁƩƱƶƠĒ

Y¡Ɣ{wůƑĒ

ŤŲƏŨY¡Ɣ{wůƑĒŽŶƏƌ{wŭž
šĒŤŲƏŨ ƹ
­ƺƔ{wůƑĒ

2ũƒĒ2ũƒƏƒžšĒ

ŴƄƕ2ũƒƏƒžšĒ

ŴƄƕ2ũƒƏƒƑĒ

2ũƒƏƒƑĒ

U£4ÑlĒ

DćĒŴƄƕDćĒ

ŴƄƕ4ÑĒ

4ÑĒƙƫƦƶƠƁ´lĒ

Ē
Ē
Ē
Ē
Ē
Ē
Ē

4ÑlŦŠƑûÙlĒ

Ē
Ē
Ē
Ē

ūƉŬƉŻŠƑĒ

ƓťƏžšĒ

ĒūƉŬƉŻŠƑĒ

ƓťƏžšĒ

ĒūƉŬƉŻŠƑĒ

ƓťƏžšĒ

Ē

³ºžŭĒ

Ē

Ē

Ē
Ē

Ē

Ē

ƹ­ƺƔ{wůƑĒūƉŬƉŻŠƑĒ

ƓťƏžšĒ

ūƉŬƉŻŠƑĒ

ƓťƏžšĒ

ūƉŬƉŻŠƑĒ

ƓťƏžšĒ

Ē
Ē

Ē

Ē

Ē

ÅêĒ
Ē

ÿLl²±<9«ÌmÏſYŭźřčƔ'¸,ūűƑ3Ó!×ËƔŢƆŧťĦĒ
ĒyQƁƢƗƬĒ

ŪƁ÷tÐƂyQŻ
ŧžšĒŪƁ÷tÐƔ¦ŭžšŪżƔzůƑĒ

ŖĒĒ

ŖĒĒ

ŪƁ÷tÐƔ¦ů ŪƁ÷tÐƔ¦ůƑŪżƌ¦ŭžšŪƑŪżƔzůƑĒżƌřƔzůƑĒ
ŖĒĒ

ŗĒĒ

ŪƁ÷tÐƔyQůƑĒ

ŖĒĒ

Ē

yQĒ

ÿLl²±<9«ÌmÏſ¦šƑ3Ó!×ËƂřčƔ'¸,ūűžš3Ó!×ËƎƐřčƔ'¸,ūűƑ3Ó!×ËƔdŨyQůƑŚƹĒĭĶħĪīĒĝĨƿdšyQĒĚĒƙƫƦƶƠƁîœŔĒƺĒyQƁêvĒ

÷tūƒŴƖƘƧƚƯƂ»aƁƙƫƦƶƠƁîſŤšźřħĮį ſĂŭźčƔ'¸,ůƑ3Ó!×ËŦ¯ŻŠŷŴŚŪƁnJſƎŷźřNŨƁmÏƂčƔ'¸,ůƑ×ËƔ÷tůƑżÎţƑŚŭťŭħĮį żšŢƖƘƧƚƯƔŽƁ¹aûÛůƑťſŸšźƂmÏƁû«aŻ¨žƑŚƉŴþ¦ſŢ?5ƁM-ſŸšźèƔ2ũŴmÏƁſƂř÷tƔŭžšmÏƌŠƐhƑŚĒ

ĒĒ̛̝̜˿˻̐ǰˀ˅ñü$ã˄ʥʹʼʿ˅ȅMǰģ̕ÝǔɄɄ ɒɐɑɖ Â ə ď ɒɒ Ąʛñü˅cÝÍã˙˿˻̐ǰ˄ʿǉʼʹʜǰ˅ˀʛñü˄ǜǰʱ˖ʹ<©˙ǝʴ˕ʜɄ̕ƽĴȕ˅ȡp˄ȣʲʿˆʛũ&j˙hˎʿĔʺǭüjʫ°˃ʦʜ˿˻̏˭˷˅
˄ˆʛĴƅźĳĿū˄˒˕pc8˅÷u˙ÛƲʫ½đʲʹũ&˙ơȿʲʿʦ˕ˏ˅ˏʩ˔ʛÎ˅Č˃˕ƻÃĤǜʫÔǒˁ˅Ýǔʫ?ʱ˖ʹʜʰ˅Ŀū˄ʧ§˅j˄˒ʼʿʛı|˅÷Ǜć˄ñüʫ˘˕`ƶØˏhˎʿʛ÷ˎʿǡūˣ˞˸̎˞̔˅÷Ǜ˅ÔǒØʫŽǧʱ˖ʹʜɄ
̕^ƹ<ǎƫ˅ĿūNĠD¤ʫʛĂǞʥ˕ʦˆ ˄˒ʼʿʛ~<ˀˆ=Ŏ˄ǉ˘˖ʿʦ˃ʦśŗʫjʱ˖ʹʜȳL&ʫʴ˕^ƹ<ǎƫ˄ȣʲʿˆʛŷŵĤ
ġ˄˒˕NĠD¤ʫÔǒˀʥ˕ʜÛƲF)ʛTūơŉŮ˃1ȴ˙hˎʹĿūNĠD¤ˁʲʿ˅ ŷŵĤġ˅ÔǒØ˙ǔîʨʹÝǔʫ?ʱ˖ʹʜɄ
̕H|˅ǡūˣ˞˸̎˞̔ˀˆʛÓǇƒƘ˞̄̔˷˙˜˟˷ˢ̉ˁʲʹƻÃżƉ˅ÔǒØʫǜǰʱ˖ʹʫʛ|˅ïşǭü˙hˎʿjʫúǔʱ˖ˎʿʦ˕ʜʰ˅Ȭʛ˿˻̏˭˷˅ʪ˓ʛɠɭɞɭ ˁ ɬɞ Ŀūˀ˅ÓǇƒƘ˞̄̔˷˄˒˕ĶǾ¿˄¹ʫ˃ʪʼʹˁʲʹ˨̖̆˷żƉ̘ɞʄɷʄɺɷʃɄɞɌɄɻʊɄɷʂɎɄɯɻʉʆɿʈʅʂʅɽʏɌɄɑɘɚɄɑɑɘɔɍɑɑəɐɌɄɒɐɑɓ̙
ʫƞʱ˖ʹʜɞɥɦ ˁʦʼʹŨá˅Q˅ˍ˃˓ʵʛǇhˎʹÑŝxƘ˅tȸʛŞń˅ǹ˅g˄Ǖő˙ʩʦʹƻÃżƉ˅ÔǒØˏ>Žǧʱ˖ʹʜɄ
Ʉ̛̝̝Ėǡūˣ˞˸̎˞̔˅̋˺˰̏̔˦˄ȣʲʿɄɄ Ėǡūˣ˞˸̎˞̔ˆ ɬɞ ˄ȣʴ˕ƻÃŧt˙ ɒ ʽʥʯʿʦ˕ʜʦʵ˖ˏ˜˟˷ˢ̉÷u˅Ȑã˙ǣ(ʴ˕ˏ˅ˆʛǎƫ¢ãÎ˅ơȎǘ¬˄ʩʮ˕ǡ¬ˁʛǎƫ˙ǎŶʲʿ˅Ɵŷŵ̈̏˯̉˼˦̎́˝̖Ĥġ˙ˆʳˎˁʲʹŷŵĤġˀʥ˕ʜɬɰɞ ˄­ʴ˕ ɬɞ ˙$ãʲʹĴƅT¾˄˒˕ơȎǘ¬˅ȚǒØ˙÷ˎʿËǬʴ˕ʜɄɄ ĄĖŷŵĴƅˀˆʛq˙­ǳ˄^ƹ<ǎƫ˄ȣʴ˕˜̔˧̖˷Ǭġ˙ǉʼʹơƨʫʥ˕̘˜̔˧̖˷|\Ś ɑɔɎɓɇ̙ʜʰ˅āŁ˙÷uFşʲʿʛŷŵĤġ˙hˎʹơȎǘ¬ʫǉ˘˖ʿʦ˕śŗ˙Ǭġʲʛǡūˣ˞˸̎˞̔˅Fş˄ȣʴ˕̋˺˰̏
̔˦ˁʴ˕ ¤ˀʥ˕ʜɄ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ
Ʉ

23

̛̝̞6ǵȵɄɄ Ėǡūˣ˞˸̎˞̔ˆɫɭɬŁĄĖŷŵĴƅ˄˒˔$ãʱ˖ʹǡūˣ˞˸̎˞̔ˀʥ˕ʜĖˆʛĖǡūˣ˞˸̎˞̔˅Fş˄ȣʲʿʛ%şƲˏʲʭˆƍƲ˄Şʳʹʛʥ˓ˑ˕õ§ʩ˒ˇõ˄ʽʦʿʛAǵˆǴ˘˃ʦʜ%şƲˆƼ˓˅ǵ˄ʩʦʿĖǡūˣ˞˸̎˞̔˙Fşʴ˕ˏ˅ˁʴ˕ʜɄ

̛̝̟ǂ$ĬɄɄ Ėǡūˣ˞˸̎˞̔ˆ ɫɭɬ ŁĄĖŷŵĴƅʫäĐʲʿʦ˕ʜčȴ˄˒˕ǟ`˃ʭʛ-Ů˃ŰŮˀ%şʴ˕ʰˁˆƁĲʴ˕ʜɄɄȅMǸý̦ȨǭüǗɄ

24

論文名

著者

詳細

除外理由

1 CPAP vs Mandibular Advancement Devices and Blood Pressure in
Bratton DJ
Patients With Obstructive Sleep Apnea: A Systematic Review and Metaanalysis.

JAMA. 2015 Dec
1;314(21):2280-93.

総論

2 Management of obstructive sleep apnea in edentulous patients: an
overview of the literature.

Heidsieck DS

Sleep Breath. 2015 Nov
19.

総論

3 Comparison of the effects of continuous positive airway pressure andmandibular advancement devices on sleepiness in patients with
obstructive sleep apnoea: a network meta-analysis.

Bratton DJ

Lancet Respir Med. 2015 総論
Nov;3(11):869-78.

4 The effectiveness of oral appliances for obstructive sleep apnea
syndrome: A meta-analysis.

Zhu YJ Dent. 2015 Oct 17

総論

5 Comparison of effects of OSA treatment by MAD and by CPAP on
cardiac autonomic function during daytime.

Glos M

Sleep Breath. 2015 Oct
13.

口腔内装置とCPAPの比較である

6 Determinants of Objective Compliance During Oral Appliance Therapy in Dieltjens M
Patients With Sleep-Related Disordered Breathing: A Prospective Clinical
Trial.

JAMA Otolaryngol Head
Neck Surg. 2015 Sep
24:894-900.

非ランダム化比較試験

7 Socio-Economic Status: A Barrier to Access to Mandibular Advancement Fleury M
Device Therapy for Patients with Obstructive Sleep Apnea Syndrome inFrance.

PLoS One. 2015 Sep
24;10(9):e0138689.

観察研究

9 A Comparison of Different Success Definitions in Non-Continuous
Positive Airway Pressure Treatment for Obstructive Sleep Apnea Using
Cardiopulmonary Coupling.

Lee WHJ Clin Sleep Med. 2015
Jul 24.

非ランダム化比較試験

10 Comparative Effectiveness of the Different Treatment Modalities forSnoring.

Terryn S

Otolaryngol Head Neck
Surg. 2015
Sep;153(3):468-75.

アウトカムがイビキ評価

11 Effects of opioid, hypnotic and sedating medications on sleep-disordered Mason M
breathing in adults with obstructive sleep apnoea.

Cochrane Database Syst 口腔内装置についての論文ではない
Rev. 2015 Jul
14;7:CD011090.

12 Drug-Induced Sedation Endoscopy in the Evaluation of OSA Patientswith Incomplete Oral Appliance Therapy Response.

Kent DT

Otolaryngol Head Neck
Surg. 2015
Aug;153(2):302-7.

14 Predictors of success in the treatment of obstructive sleep apnea
syndrome with mandibular repositioning appliance: a systematic review.

Saffer F

Int Arch Otorhinolaryngol. 総論
2015 Jan;19(1):80-5.

15 Do Mandibular Advancement Devices Influence Patients' Snoring andObstructive Sleep Apnea? A Cone-Beam Computed Tomography
Analysis of the Upper Airway Volume.

Marcussen L

J Oral Maxillofac Surg.
2015 Sep;73(9):1816-26.

対象にOSA以外の患者が含まれている

16 Management of sleep apnea: a critical look at intra-oral appliances.

Conley RS

Orthod Craniofac Res.
2015 Apr;18 Suppl 1:8390.

総論

17 Mandibular advancement appliances for the treatment of paediatricobstructive sleep apnea: a systematic review.

Nazarali N

Eur J Orthod. 2015
Dec;37(6):618-26.

総論

18 Prediction of oral appliance treatment outcome in obstructive sleep
apnoea syndrome: a preliminary study.

Suzuki K

B-ENT. 2014;10(3):18591.

非ランダム化比較試験

19 [Comparison of the efficacy of 2 types of mandibular advancement
device in severe obstructive sleep apnea hypopnea syndrome].

Wang L

Shanghai Kou Qiang Yi
２種類の口腔内装置の比較である
Xue. 2014 Dec;23(6):7137.

20 An evaluation of two different mandibular advancement devices on
Geoghegan F
craniofacial characteristics and upper airway dimensions of Chinese adultobstructive sleep apnea patients.

Angle Orthod. 2015
Nov;85(6):962-8.

観察研究

２種類の口腔内装置の比較である

21 Skeletal stability of patients undergoing maxillomandibular advancement
for treatment of obstructive sleep apnea.

Lee SHJ Oral Maxillofac Surg.
2015 Apr;73(4):694-700.

口腔内装置についての論文ではない

22 Improved apnea-hypopnea index and lowest oxygen saturation after
Knudsen TB
maxillomandibular advancement with or without counterclockwise rotationin patients with obstructive sleep apnea: a meta-analysis.

J Oral Maxillofac Surg.
2015 Apr;73(4):719-26.

口腔内装置についての論文ではない

23 Three-dimensional cone-beam computed tomography analysis ofenlargement of the pharyngeal airway by the Herbst appliance.

Am J Orthod Dentofacial 観察研究
Orthop. 2014
Dec;146(6):776-85.

Iwasaki T

24 Effect of treatment of obstructive sleep apnea on depressive symptoms: Povitz M
systematic review and meta-analysis.

PLoS Med. 2014 Nov
25;11(11):e1001762.

総論

25 Clinical effectiveness and cost-effectiveness results from the
Sharples L
randomised controlled Trial of Oral Mandibular Advancement Devices for
Obstructive sleep apnoea-hypopnoea (TOMADO) and long-term
economic analysis of oral devices and continuous positive airway
pressure.

Health Technol Assess.
2014 Oct;18(67):1-296.

３種類の口腔内装置の比較や口腔内装置とCPAPの比較である

26 Influence of craniofacial and upper spine morphology on mandibularadvancement device treatment outcome in patients with obstructive
sleep apnoea: a pilot study.

Svanholt P

Eur J Orthod. 2015
Aug;37(4):391-7.

アウトカムがセファロ評価

27 Exploring the Potential Cost-Effectiveness of Patient Decision Aids for
Use in Adults with Obstructive Sleep Apnea: A Case Study.

Trenaman L

Med Decis Making. 2015
Jul;35(5):671-82.

口腔内装置についての論文ではない

28 A promising concept of combination therapy for positional obstructive
sleep apnea.

Dieltjens M

Sleep Breath. 2015
May;19(2):637-44.

口腔内装置と睡眠体位の是正に関する装置の比較である

29 Are you prescribing bruxism appliances?

Malcmacher L

Dent Today. 2014
Sep;33(9):126-9.

口腔内装置についての論文ではない

30 Effects of a mandibular advancement device on genioglossus in
obstructive sleep apnoea hypopnea syndrome.

Liu CY

Eur J Orthod. 2015
Jun;37(3):290-6.

口腔内装置についての論文ではない

31 An animal model of obstructive sleep apnoea-hypopnea syndrome
corrected by mandibular advancement device.

Lu HY

Eur J Orthod. 2015
Jun;37(3):284-9.

口腔内装置についての論文ではない

32 Pre-emptive analgesia with pregabalin and celecoxib decreases
postsurgical pain following maxillomandibular advancement surgery: arandomized controlled clinical trial.

Cillo JE Jr

J Oral Maxillofac Surg.
口腔内装置についての論文ではない
2014 Oct;72(10):1909-14.

33 CPAP pressure for prediction of oral appliance treatment response in
obstructive sleep apnea.

Sutherland K

J Clin Sleep Med. 2014
Sep 15;10(9):943-9.

口腔内装置の治療効果予測に関する論文

34 Examining the mechanism of action of a new device using oral pressure
therapy for the treatment of obstructive sleep apnea.

Schwab RJ

Sleep. 2014 Jul
1;37(7):1237-47.

観察研究

35 A crossover randomised controlled trial of oral mandibular advancement
devices for obstructive sleep apnoea-hypopnoea (TOMADO).

Quinnell TG

Thorax. 2014
Oct;69(10):938-45.

他の検索論文と同じデータである

36 [Oral-appliance for erectile dysfunction induced by obstructive sleep
apnea-hypopnea syndrome].

Zhang T

Zhonghua Nan Ke Xue.
2014 Jun;20(6):510-3.

非ランダム化比較試験

37 Different therapeutic mechanisms of rigid and semi-rigid mandibular
repositioning devices in obstructive sleep apnea syndrome.

Suga HJ Craniomaxillofac Surg.
2014 Dec;42(8):1650-4.

２種類の口腔内装置の比較である

38 A pilot study to compare patient perception of obstructive sleep apnea
treatment with CPAP or appliance therapy.

Arya D

J Prosthet Dent. 2014
Nov;112(5):1188-93.

口腔内装置とCPAPの比較である

39 Advances in the treatment of obstructive sleep apnea.

Young D

Curr Treat Options
Neurol. 2014
Aug;16(8):305.

総論

40 Comparison of the effects of mandibular protruding devices on
obstructive sleep apnoea patients and healthy volunteers.

Acar MJ Craniomaxillofac Surg.
2014 Oct;42(7):1465-8.

アウトカムがCT評価

41 Positional OSA part 1: Towards a clinical classification system for
position-dependent obstructive sleep apnoea.

Frank MH

Sleep Breath. 2015
May;19(2):473-80.

口腔内装置についての論文ではない

42 Orthognathic surgery in patients over 40 years of age: indications andspecial considerations.

Peacock ZS

J Oral Maxillofac Surg.
2014 Oct;72(10):19952004.

口腔内装置についての論文ではない

43 Efficacy of uvulopalatopharyngoplasty combined with oral appliance intreatment of obstructive sleep apnea-hypopnea syndrome.

Yang D

Ir J Med Sci. 2015
Jun;184(2):329-34.

口腔内装置と外科手術の比較である

44 [Therapeutic effects of oral appliance combined withuvulopalatopharyngoplasty on obstructive sleep apnea hypopnea
syndrome].

Han J

Zhonghua Kou Qiang Yi
Xue Za Zhi. 2014
Feb;49(2):69-72.

口腔内装置と外科手術の比較である

45 Craniofacial characteristics of successful responders to mandibularadvancement splint therapy: a pilot study.

Seehra J

Br J Oral Maxillofac Surg. アウトカムがセファロ評価
2014 Apr;52(4):314-6.

46 Modulation of inflammatory and hemostatic markers in obstructive sleep
apnea patients treated with mandibular advancement splints: a parallel,
controlled trial.

NizankowskaJedrzejczyk A

J Clin Sleep Med. 2014
Mar 15;10(3):255-62.

アウトカムが血液検査

47 Videoendoscopic diagnosis for predicting the response to oral appliancetherapy in severe obstructive sleep apnea.

Sasao Y

Sleep Breath. 2014
Dec;18(4):809-15.

内視鏡検査に関する論文

49 Adjustable thermoplastic mandibular advancement device for obstructive Banhiran W
sleep apnea: outcomes and practicability.

Laryngoscope. 2014
Oct;124(10):2427-32.

非ランダム化比較試験

50 Effect of mandibular advancement device therapy on the signs andsymptoms of temporomandibular disorders.

Napankangas R

J Oral Maxillofac Res.
2013 Jan 1;3(4):e5.

口腔内装置の副作用に関する論文

51 The COMET Sleep Research Platform.

Nichols DA

EGEMS (Wash DC). 2014 口腔内装置についての論文ではない
Nov 24;2(1):1059.

53 Craniofacial and upper airway morphology in pediatric sleep-disorderedbreathing and changes in quality of life with rapid maxillary expansion.

Katyal V

Am J Orthod Dentofacial 対象が小児である
Orthop. 2013
Dec;144(6):860-71.

54 Mandibular advancement for obstructive sleep apnea: relating outcomesto anatomy.

Friedman M

JAMA Otolaryngol Head
Neck Surg. 2014
Jan;140(1):46-51.

観察研究

55 Recent advances in sleep research.

Saletu B

Psychiatr Danub. 2013
Dec;25(4):426-34.

総論

56 Drug-induced sleep endoscopy changes snoring management plan verysignificantly compared to standard clinical evaluation.

Pilaete K

Eur Arch
Otorhinolaryngol. 2014
May;271(5):1311-9.

内視鏡検査に関する論文

57 Mandibular tori size is related to obstructive sleep apnea and treatment
success with an oral appliance.

Palm E

Sleep Breath. 2014
May;18(2):431-8.

評価方法がPSGではない

58 Effect of CPAP on blood pressure in patients with OSA/hypopnea asystematic review and meta-analysis.

Fava C

Chest. 2014
Apr;145(4):762-71.

口腔内装置についての論文ではない

59 Comparison of the effects of continuous positive airway pressure, oral
appliance and exercise training in obstructive sleep apnea syndrome.

Schutz TC

Clinics (Sao Paulo).
2013;68(8):1168-74.

運動療法に関する論文

60 Mandibular advancement device vs. CPAP in the treatment of
obstructive sleep apnea: are they equally effective in Short term healthoutcomes?

White DPJ Clin Sleep Med. 2013
Sep;9(9):971-2.

口腔内装置とCPAPの比較である

61 Oral appliance versus continuous positive airway pressure in obstructive Doff MH
sleep apnea syndrome: a 2-year follow-up.

Sleep. 2013 Sep
1;36(9):1289-96.

口腔内装置とCPAPの比較である

62 Association between resting jaw muscle electromyographic activity andmandibular advancement splint outcome in patients with obstructive
sleep apnea.

Ma SY

Am J Orthod Dentofacial 非ランダム化比較試験
Orthop. 2013
Sep;144(3):357-67.

63 Newer treatment modalities for pediatric obstructive sleep apnea.

Tapia IE

Paediatr Respir Rev.
2013 Sep;14(3):199-203.

対象が小児である

64 Influencing factors on the effect of mandibular advancement device inobstructive sleep apnea patients: analysis on cephalometric andpolysomnographic parameters.

Kim YK

Sleep Breath. 2014
May;18(2):305-11.

非ランダム化比較試験

65 Objectively measured vs self-reported compliance during oral appliancetherapy for sleep-disordered breathing.

Dieltjens M

Chest. 2013
Nov;144(5):1495-502.

口腔内装置のコンプライアンスに関する論文

66 Evaluation of a novel device for measuring patient compliance with oral
appliances in the treatment of obstructive sleep apnea.

Smith YKJ Prosthodont. 2014
Jan;23(1):31-8.

口腔内装置のコンプライアンスに関する論文

67 Effects of occlusal stabilization splints on obstructive sleep apnea: arandomized controlled trial.

Nikolopoulou M

J Orofac Pain. 2013
Summer;27(3):199-205.

口腔内装置が基準を満たさない

68 A multicenter evaluation of oral pressure therapy for the treatment of
obstructive sleep apnea.

Colrain IM

Sleep Med. 2013
Sep;14(9):830-7.

口腔内装置についての論文ではない

69 Factors associated with the efficacy of mandibular advancing device
treatment in adult OSA patients.

Milano F

Int Orthod. 2013
Sep;11(3):278-89.

アウトカムがセファロ評価

70 Efficacy of an oral appliance for the treatment of obstructive sleep
apnea.

Giannasi LC

Int J Prosthodont. 2013
Jul-Aug;26(4):334-9.

対象にOSA以外の患者が含まれている

71 Obstructive sleep apnea is a predictor of abnormal glucose metabolism in Cizza G
chronically sleep deprived obese adults.

PLoS One. 2013 May
29;8(5):e65400.

口腔内装置についての論文ではない

72 Cardiovascular mortality in obstructive sleep apnoea treated with
continuous positive airway pressure or oral appliance: an observational
study.

Anandam A

Respirology. 2013
Nov;18(8):1184-90.

口腔内装置とCPAPの比較である

73 Continuous lesser palatine nerve block for postoperative analgesia after
uvulopalatopharyngoplasty.

Ponstein NA

Clin J Pain. 2013
Dec;29(12):e35-8.

口腔内装置についての論文ではない

74 A randomized crossover study comparing two mandibular repositioning
appliances for treatment of obstructive sleep apnea.

Bishop B

Sleep Breath. 2014
Mar;18(1):125-31.

２種類の口腔内装置の比較である

75 Sleep bruxism, snoring, and headaches in adolescents: short-term effects Carra MCof a mandibular advancement appliance.

Sleep Med. 2013
Jul;14(7):656-61.

評価方法がPSGではない

76 Mandibular advancement splint as short-term alternative treatment inpatients with obstructive sleep apnea already effectively treated with
continuous positive airway pressure.

J Clin Sleep Med. 2013
Apr 15;9(4):319-24.

口腔内装置とCPAPの比較である

Almeida FR

77 Can gestational hypertension be modified by treating nocturnal airflow
limitation?

Reid JJ Clin Sleep Med. 2013
Apr 15;9(4):311-7.

口腔内装置とCPAPの比較である

78 Mandibular advancement appliances for treating sleep apnoea/hypopnoea Borrie F
syndrome.

Evid Based Dent. 2013
Mar;14(1):27-8.

２種類の口腔内装置の比較である

79 Effects of surgical vs. nonsurgical therapy on erectile dysfunction andquality of life in obstructive sleep apnea syndrome: a pilot study.

J Sex Med. 2013
Aug;10(8):2053-9.

口腔内装置とCPAPと外科手術の比較である

80 Primary care vs specialist sleep center management of obstructive sleep Chai-Coetzer CL
apnea and daytime sleepiness and quality of life: a randomized trial.

JAMA. 2013 Mar
13;309(10):997-1004.

口腔内装置についての論文ではない

81 Treatment outcomes and compliance according to obesity in patientswith obstructive sleep apnea.

Eur Arch
Otorhinolaryngol. 2013
Nov;270(11):2885-90.

口腔内装置とCPAPと外科手術の比較である

82 Health outcomes of continuous positive airway pressure versus oral
Phillips CL
appliance treatment for obstructive sleep apnea: a randomized controlled
trial.

Am J Respir Crit CareMed. 2013 Apr
15;187(8):879-87.

口腔内装置とCPAPの比較である

83 Changes in facial profile after maxillomandibular advancement surgery for Cohen-Levy J
obstructive sleep apnea syndrome.

Int Orthod. 2013
Mar;11(1):71-92.

口腔内装置についての論文ではない

84 Effect of oral appliances on blood pressure in obstructive sleep apnea: a Iftikhar IH
systematic review and meta-analysis.

J Clin Sleep Med. 2013
Feb 1;9(2):165-74.

総論

85 Comparative effectiveness of maxillomandibular advancement anduvulopalatopharyngoplasty for the treatment of moderate to severe
obstructive sleep apnea.

J Oral Maxillofac Surg.
2013 Apr;71(4):743-51.

口腔内装置と外科手術の比較である

86 A randomised titrated crossover study comparing two oral appliances in Zhou J
the treatment for mild to moderate obstructive sleep apnoea/hypopnoea
syndrome.

J Oral Rehabil. 2012
Dec;39(12):914-22.

２種類の口腔内装置の比較である

87 Objective measurement of compliance during oral appliance therapy forsleep-disordered breathing.

Vanderveken OM

Thorax. 2013
Jan;68(1):91-6.

口腔内装置のコンプライアンスに関する論文

88 Treatment of sleep apnoea using a mandibular advancement splint--an
open prospective study.

Lekerud AK

In Vivo. 2012 SepOct;26(5):841-5.

観察研究

89 Computed tomographic evaluation of the effects of mandibularadvancement devices on pharyngeal dimension changes in patients with
obstructive sleep apnea.

Kaur AInt J Prosthodont. 2012
Sep-Oct;25(5):497-505.

非ランダム化比較試験

90 Effects of treatment with oral appliance on 24-h blood pressure inpatients with obstructive sleep apnea and hypertension: a randomized
clinical trial.

Andren A

Sleep Breath. 2013
May;17(2):705-12.

評価方法がPSGではない

91 The effectiveness of oral appliances in elderly patients with obstructive
sleep apnoea treated with lorazepam--a pilot study.

Tihacek-Sojic L

J Oral Rehabil. 2012
Oct;39(10):785-90.

ロラゼパムに関する論文

92 The effect of positional dependency on outcomes of treatment with amandibular advancement device.

Lee CHArch Otolaryngol Head
Neck Surg. 2012
May;138(5):479-83.

観察研究

93 Efficacy of the Silensor for treating obstructive sleep apnea syndrome.

Nakano H

Oral Maxillofac Surg.
2013 Jun;17(2):105-8.

非ランダム化比較試験

94 Long-term oral appliance therapy in obstructive sleep apnea syndrome: a Doff MH
controlled study on dental side effects.

Clin Oral Investig. 2013
Mar;17(2):475-82.

口腔内装置とCPAPの比較である

Shin HWKim H

Boyd SB

95 Association of genetic, psychological and behavioral factors with sleep
bruxism in a Japanese population.

Abe Y

J Sleep Res. 2012
Jun;21(3):289-96.

口腔内装置についての論文ではない

96 [Effect of jaw forward distance on forced inspiratory airflow in patientswith obstructive sleep apnea hypopnea syndrome].

Zhang W

Zhonghua Er Bi Yan Hou アウトカムが吸気速度
Tou Jing Wai Ke Za Zhi.
2012 Jan;47(1):39-43.

97 Initial Evaluation of a Titration Appliance for Temporary Treatment of
Obstructive Sleep Apnea.

Levendowski DJ

J Sleep Disord Ther.
2012 Jan;1(1).

口腔内装置の治療効果予測に関する論文

98 Improved cognitive functions after treatment with an oral appliance inobstructive sleep apnea.

Tegelberg A

Nat Sci Sleep. 2012 Aug
22;4:89-96.

非ランダム化比較試験

99 How to treat patients with obstructive sleep apnea syndrome during an
altitude sojourn.

Latshang TD

High Alt Med Biol. 2011
Winter;12(4):303-7.

口腔内装置についての論文ではない

100 Non-CPAP therapies in obstructive sleep apnoea: mandibularadvancement device therapy.

Marklund M

Eur Respir J. 2012
May;39(5):1241-7.

総論

101 Comparison of titratable oral appliance and mandibular advancement
splint in the treatment of patients with obstructive sleep apnea.

Sari EISRN Dent.
2011;2011:581692.

２種類の口腔内装置の比較である

102 Cephalometric evaluation of the effect of complete dentures onretropharyngeal space and its effect on spirometric values in alteredvertical dimension.

Gupta PISRN Dent.
2011;2011:516969.

口腔内装置についての論文ではない

103 Mandibular advancement appliances remain effective in lowering
respiratory disturbance index for 2.5-4.5 years.

Gauthier L

Sleep Med. 2011
Oct;12(9):844-9.

２種類の口腔内装置の比較である

104 Effects of fixed appliances in correcting Angle Class II on the depth ofthe posterior airway space: FMA vs. Herbst appliance--a retrospective
cephalometric study.

Kinzinger G

J Orofac Orthop. 2011
Aug;72(4):301-20.

２種類の口腔内装置の比較である

105 A mandibular advancement appliance reduces pain and rhythmic
masticatory muscle activity in patients with morning headache.

Franco L

J Orofac Pain. 2011
Summer;25(3):240-9.

起床時の頭痛に関する論文

106 Nasal versus oronasal continuous positive airway pressure masks for
obstructive sleep apnea: a pilot investigation of pressure requirement,
residual disease, and leak.

Bakker JP

Sleep Breath. 2012
Sep;16(3):709-16.

口腔内装置についての論文ではない

107 Subjective outcomes of maxillomandibular advancement surgery fortreatment of obstructive sleep apnea syndrome.

Goodday R

J Oral Maxillofac Surg.
2012 Feb;70(2):417-20.

口腔内装置についての論文ではない

108 Does propulsion mechanism influence the long-term side effects of oral
appliances in the treatment of sleep-disordered breathing?

Vezina JP

Chest. 2011
Nov;140(5):1184-91.

口腔内装置の副作用に関する論文

109 Maxillomandibular advancement for treatment of obstructive sleep apnea Pirklbauer K
syndrome: a systematic review.

J Oral Maxillofac Surg.
2011 Jun;69(6):e165-76.

総論

110 Long-term oral appliance therapy in obstructive sleep apnea syndrome: a Doff MH
controlled study on temporomandibular side effects.

Clin Oral Investig. 2012
Jun;16(3):689-97.

口腔内装置とCPAPの比較である

111 Controlled, prospective trial of psychosocial function before and after
mandibular advancement splint therapy.

Johal AAm J Orthod Dentofacial 非ランダム化比較試験
Orthop. 2011
May;139(5):581-7.

112 Clinical equipoise in sleep surgery: investigating clinical trial targets.

Field CJ

Otolaryngol Head Neck
Surg. 2011
Aug;145(2):347-53.

口腔内装置と外科手術の比較である

113 The value of a mandibular repositioning appliance for the treatment of
nonapneic snoring.

Aarts MC

Otolaryngol Head Neck
Surg. 2011
Feb;144(2):170-3.

総論

114 Pharmacological treatment of obstructive sleep apnea.

Abad VC

Curr Pharm Des.
2011;17(15):1418-25.

口腔内装置についての論文ではない

115 Comparative effects of two oral appliances on upper airway structure in
obstructive sleep apnea.

Sutherland K

Sleep. 2011 Apr
1;34(4):469-77.

観察研究

116 Long-term follow-up of a randomized controlled trial of oral appliancetherapy in obstructive sleep apnea.

Aarab G

Respiration.
2011;82(2):162-8.

口腔内装置とCPAPの比較である

117 A systematic review of the efficacy of oral appliance design in the
management of obstructive sleep apnoea.

Ahrens A

Eur J Orthod. 2011
Jun;33(3):318-24.

総論

118 Treatment of obstructive sleep apnea reduces arterial stiffness.

Buchner NJ

Sleep Breath. 2012
Mar;16(1):123-33.

非ランダム化比較試験

119 Subjective efficacy of oral appliance design features in the managementof obstructive sleep apnea: a systematic review.

Ahrens A

Am J Orthod Dentofacial 総論
Orthop. 2010
Nov;138(5):559-76.

120 Mandibular exercises improve mandibular advancement device therapy
for obstructive sleep apnea.

Cunali PA

Sleep Breath. 2011
Dec;15(4):717-27.

運動療法に関する論文

122 Surgical treatment of obstructive sleep apnea: standard and emerging
techniques.

Maurer JT

Curr Opin Pulm Med.
2010 Nov;16(6):552-8.

総論

123 Long-term oral-appliance therapy in obstructive sleep apnea: acephalometric study of craniofacial changes.

Doff MHJ Dent. 2010
Dec;38(12):1010-8.

口腔内装置の副作用に関する論文

124 An orthodontic oral appliance.

Marklund M

Angle Orthod. 2010
Nov;80(6):1116-21.

口腔内装置の副作用に関する論文

125 Determinants of treatment outcome after use of the mandibularadvancement device in patients with obstructive sleep apnea.

Lee CHArch Otolaryngol Head
Neck Surg. 2010
Jul;136(7):677-81.

内視鏡検査に関する論文

126 Randomised cross-over study of oral appliances for snoring.

Maguire J

Clin Otolaryngol. 2010
Jun;35(3):204-9.

対象にOSA以外の患者が含まれている

127 Effectiveness of maxillo-mandibular advancement in obstructive sleep
apnea patients with and without skeletal anomalies.

Ronchi P

Int J Oral Maxillofac
口腔内装置についての論文ではない
Surg. 2010 Jun;39(6):5417.

128 A pilot study to evaluate posttreatment cephalometric changes insubjects with OSA.

Arya D

J Prosthet Dent. 2010
Mar;103(3):170-7.

口腔内装置とCPAPの比較である

129 Oral appliance titration in patients with obstructive sleep apnea induces
the appearance of periodic limb movements.

Guerrero ML

Sleep Breath. 2010
Dec;14(4):359-63.

観察研究

130 [Effects of oral appliance treatment upon blood pressure in mild tomoderate obstructive sleep apnea-hypopnea syndrome].

Zhang LQ

Zhonghua Yi Xue Za Zhi. 血圧に関する論文
2009 Jul 14;89(26):180710.

131 Surgery vs ventilation in adult severe obstructive sleep apnea syndrome. Vicini C

Am J Otolaryngol. 2010
Jan-Feb;31(1):14-20.

口腔内装置についての論文ではない132 The effect of a mandibular advancement splint on electromyographic
activity of the submental and masseter muscles in patients with
obstructive sleep apnea.

Kurtulmus H

Int J Prosthodont. 2009
Nov-Dec;22(6):586-93.

筋緊張に関する論文

133 Uvulopalatopharyngoplasty in 158 OSAS patients failing non-surgicaltreatment.

Lundkvist K

Acta Otolaryngol. 2009
Nov;129(11):1280-6.

口腔内装置についての論文ではない

134 Effect of an adjustable mandibular advancement appliance on sleep
bruxism: a crossover sleep laboratory study.

Landry-Schonbeck A Int J Prosthodont. 2009
May-Jun;22(3):251-9.

ブラキシズムに関する論文

135 Effects of an oral appliance with different mandibular protrusion positions Aarab G
at a constant vertical dimension on obstructive sleep apnea.

Clin Oral Investig. 2010
Jun;14(3):339-45.

ランダム化比較試験として扱うべきか不明瞭であり、他の論文での口腔内装置の下顎位を決定するための研究と考えられたので除外した

136 Comparative evaluation of the breaking strength of a simple mobile
mandibular advancement splint.

Tanoue N

Eur J Orthod. 2009
Dec;31(6):620-4.

非ランダム化比較試験

137 A randomized prospective long-term study of two oral appliances forsleep apnoea treatment.

Ghazal A

J Sleep Res. 2009
Sep;18(3):321-8.

２種類の口腔内装置の比較である

138 Comparison of mandibular advancement splint and tongue stabilizing
device in obstructive sleep apnea: a randomized controlled trial.

Deane SA

Sleep. 2009 May;32(5):64 ２種類の口腔内装置の比較である

139 The mandibular advancement device and patient selection in thetreatment of obstructive sleep apnea.

Lee CHArch Otolaryngol Head
Neck Surg. 2009
May;135(5):439-44.

観察研究

140 Comparison of hypopnea definitions in lean patients with known
obstructive sleep apnea hypopnea syndrome (OSAHS).

Guilleminault C

Sleep Breath. 2009
Nov;13(4):341-7.

口腔内装置についての論文ではない

141 Effect of 2 jaw exercises on occlusal function in patients with obstructive Ueda H
sleep apnea during oral appliance therapy: a randomized controlled trial.

m J Orthod Dentofacial
Orthop. 2009
Apr;135(4):430.e1-7;
discussion 430-1.

口腔内装置の副作用に関する論文

142 Titrated mandibular advancement versus positive airway pressure forsleep apnoea.

Gagnadoux F

Eur Respir J. 2009
Oct;34(4):914-20.

口腔内装置とCPAPの比較である

143 [The value of treadmill exercise test for patients with moderate
obstructive sleep apnea-hypopnea syndrome].

Wang FLin Chung Er Bi Yan Hou 口腔内装置と外科手術の比較である
Tou Jing Wai Ke Za Zhi.
2008 Oct;22(19):891-3.

144 Microvascular endothelial function in obstructive sleep apnea: Impact ofcontinuous positive airway pressure and mandibular advancement.

Trzepizur W

Sleep Med. 2009
Aug;10(7):746-52.

口腔内装置とCPAPの比較である

145 Objective evaluation of tongue base snoring after the use of an oral
appliance: a prospective case series.

Abo-Khatwa MM

Clin Otolaryngol. 2008
Dec;33(6):592-5.

観察研究

146 Oral appliances for obstructive sleep apnea: an evidence-based analysis. No authors listed

Ont Health Technol
総論
Assess Ser. 2009;9(5):151. Epub 2009 Sep 1.

147 The attitudes of general dental practitioners and medical specialists to
Jauhar S
the provision of intra-oral appliances for the management of snoring andsleep apnoea.

Br Dent J. 2008 Dec
20;205(12):653-7;
dicussion 647.

観察研究

148 Mandibular advancement splint titration in obstructive sleep apnoea.

Sleep Breath. 2009
May;13(2):157-62.

口腔内装置のタイトレーションに関する論文

Campbell AJ

149 Three-dimensional computer-assisted study model analysis of long-term Chen H
oral-appliance wear. Part 1: Methodology.

Am J Orthod Dentofacial 口腔内装置の副作用に関する論文
Orthop. 2008
Sep;134(3):393-407.

150 Assessment of the test-retest reliability of laboratory polysomnography. Levendowski DJ

Sleep Breath. 2009
May;13(2):163-7.

口腔内装置についての論文ではない

151 Obstructive sleep apnea therapy.

Hoekema A

J Dent Res. 2008
Sep;87(9):882-7.

口腔内装置とCPAPの比較である

152 Screening for obstructive sleep apnea in the dental office setting.

Demko BG

J Mass Dent Soc. 2008
Spring;57(1):18-20.

口腔内装置についての論文ではない

153 Efficacy of two mandibular advancement appliances in the managementof snoring and mild-moderate sleep apnea: a cross-over randomized
study.

Gauthier L

Sleep Med. 2009
Mar;10(3):329-36.

２種類の口腔内装置の比較である

155 A randomized, controlled, crossover study of a noncustomized tongue
retaining device for sleep disordered breathing.

Dort L

Sleep Breath. 2008
Nov;12(4):369-73.

口腔内装置の形態がTRDである

156 A randomized crossover trial of conservative snoring treatments:
mandibular repositioning splint and nasal CPAP.

Robertson S

Otolaryngol Head Neck
Surg. 2008
Mar;138(3):283-288.

口腔内装置とCPAPの比較である

157 Prevalence of treatment choices for snoring and sleep apnea in an
Australian population.

Marshall NS

J Clin Sleep Med. 2007
Dec 15;3(7):695-9.

口腔内装置についての論文ではない

158 Effects of oral appliances and CPAP on the left ventricle and natriuretic Hoekema A
peptides.

Int J Cardiol. 2008 Aug
18;128(2):232-9. Epub
2007 Aug 28.

口腔内装置とCPAPの比較である

159 Effects of a mandibular repositioning appliance on sleep structure,morning behavior and clinical symptomatology in patients with snoringand sleep-disordered breathing.

Neuropsychobiology.
2007;55(3-4):184-93.
Epub 2007 Aug 14.

非ランダム化比較試験

160 Comparison of a custom-made and a thermoplastic oral appliance for the Vanderveken OM
treatment of mild sleep apnea.

Am J Respir Crit CareMed. 2008 Jul
15;178(2):197-202. Epub
2007 Aug 2.

対象にOSA以外の患者が含まれている

161 [Usefulness of cephalometric measurements in the diagnostics ofpatients with obstructive sleep apnea syndrome--preliminary report].

Olszewska E

Otolaryngol Pol.
2007;61(1):95-101.

口腔内装置についての論文ではない

162 Effect of oral appliance therapy on neurobehavioral functioning in
obstructive sleep apnea: a randomized controlled trial.

Naismith SL

J Clin Sleep Med. 2005
Oct 15;1(4):374-80.

他の検索論文と同じデータである

163 Long-term compliance and side effects of oral appliances used for thetreatment of snoring and obstructive sleep apnea syndrome.

de Almeida FR

J Clin Sleep Med. 2005
Apr 15;1(2):143-52.

口腔内装置のコンプライアンスに関する論文

164 The effects of 1-year treatment with a herbst mandibular advancement
splint on obstructive sleep apnea, oxidative stress, and endothelial
function.

Itzhaki S

Chest. 2007
Mar;131(3):740-9.

非ランダム化比較試験

165 [Lateral cephalometric radiography of the upper airways for evaluation of Teitelbaum J
surgical treatment of obstructive sleep apnea syndrome].

Rev Stomatol Chir
Maxillofac. 2007
Feb;108(1):13-20. Epub
2007 Jan 29.

口腔内装置についての論文ではない

166 Simulated driving in obstructive sleep apnoea-hypopnoea; effects of oral Hoekema A
appliances and continuous positive airway pressure.

Sleep Breath. 2007
Sep;11(3):129-38.

口腔内装置とCPAPの比較である

167 Rapid maxillary expansion in children with obstructive sleep apnea
syndrome: 12-month follow-up.

Villa MP

Sleep Med. 2007
Mar;8(2):128-34. Epub
2007 Jan 18.

口腔内装置についての論文ではない

168 Reduction of sleep bruxism using a mandibular advancement device: anexperimental controlled study.

Landry ML

Int J Prosthodont. 2006
Nov-Dec;19(6):549-56.

対象にOSA以外の患者が含まれている

Saletu A

169 Review of oral appliances for treatment of sleep-disordered breathing.

Hoffstein V

Sleep Breath. 2007
Mar;11(1):1-22.

総論

170 Randomised study of three non-surgical treatments in mild to moderate
obstructive sleep apnoea.

Lam B

Thorax. 2007
Apr;62(4):354-9. Epub
2006 Nov 22.

口腔内装置とCPAPと睡眠衛生指導の比較である

171 Autonomic cardiac modulation in obstructive sleep apnea: effect of anoral jaw-positioning appliance.

Coruzzi P

Chest. 2006
Nov;130(5):1362-8.

非ランダム化比較試験

172 Sexual function and obstructive sleep apnea-hypopnea: a randomized
clinical trial evaluating the effects of oral-appliance and continuous
positive airway pressure therapy.

Hoekema A

J Sex Med. 2007 Jul;4(4 口腔内装置とCPAPの比較である
Pt 2):1153-62. Epub 2006
Nov 1.

173 Health-related quality of life in patients with sleep-disordered breathing: Johal A
effect of mandibular advancement appliances.

J Prosthet Dent. 2006
Oct;96(4):298-302.

非ランダム化比較試験

174 Pressure-relief continuous positive airway pressure vs constantcontinuous positive airway pressure: a comparison of efficacy andcompliance.

Nilius G

Chest. 2006
Oct;130(4):1018-24.

口腔内装置についての論文ではない

175 Medical therapy for obstructive sleep apnea: a review by the Medical
Therapy for Obstructive Sleep Apnea Task Force of the Standards ofPractice Committee of the American Academy of Sleep Medicine.

Veasey SC

Sleep. 2006
Aug;29(8):1036-44.

総論

176 Continuous positive airways pressure for obstructive sleep apnoea in
adults.

Giles TL

Cochrane Database Syst 総論
Rev. 2006 Jul
19;(3):CD001106.

177 Genioplasty distraction osteogenesis and hyoid advancement forHeller JB
correction of upper airway obstruction in patients with Treacher Collins
and Nager syndromes.

Plast Reconstr Surg.
口腔内装置についての論文ではない
2006 Jun;117(7):2389-98.

178 A thermoplastic mandibular advancement device for the management of
non-apnoeic snoring: a randomized controlled trial.

Cooke ME

Eur J Orthod. 2006
Aug;28(4):327-38. Epub
2006 Jun 13.

179 Alternatives to CPAP in the treatment of the obstructive sleep apnea
syndrome.

Bloch KE

Swiss Med Wkly. 2006
総論
Apr 29;136(17-18):261-7.

180 Silencing the snorers: no gain without pain?

Wilson JA

J Laryngol Otol. 2006
Jul;120(7):570-4. Epub
2006 May 12.

181 CPAP devices: encouraging patients with sleep apnea.

Dickerson SS

Rehabil Nurs. 2006 May- 口腔内装置についての論文ではない
Jun;31(3):114-22.

182 Oral appliances for snoring and obstructive sleep apnea: a review.

Ferguson KA

Sleep. 2006
Feb;29(2):244-62.

総論

183 Effect on blood pressure of oral appliance therapy for sleep apnea
syndrome.

Yoshida K

Int J Prosthodont. 2006
Jan-Feb;19(1):61-6.

観察研究

対象にOSA以外の患者が含まれている

観察研究

184 A comparison of responders and nonresponders to oral appliance therapy Otsuka R
for the treatment of obstructive sleep apnea.

Am J Orthod Dentofacial 観察研究
Orthop. 2006
Feb;129(2):222-9.

185 Measurement techniques predicting the effectiveness of an oral
appliance for obstructive sleep apnea hypopnea syndrome.

Horiuchi A

Angle Orthod. 2005
Nov;75(6):1003-11.

186 Continuous positive airways pressure for obstructive sleep apnoea in
adults.

Giles TL

Cochrane Database Syst 総論
Rev. 2006 Jan
25;(1):CD001106.

口腔内装置の治療効果予測に関する論文

187 Efficacy and comorbidity of oral appliances in the treatment of
obstructive sleep apnea-hypopnea: a systematic review and preliminary
results of a randomized trial.

Hoekema A

Sleep Breath. 2006
Jun;10(2):102-3.

総論

188 The effect of oral appliance therapy on blood pressure in patients with
obstructive sleep apnea.

Otsuka R

Sleep Breath. 2006
Mar;10(1):29-36.

血圧に関する論文

189 Oral appliance therapy for obstructive sleep apnea.

Ng A

Treat Respir Med.
2005;4(6):409-22.

総論

190 The effect of a mandibular advancement splint in subjects with sleeprelated breathing disorders.

Johal ABr Dent J. 2005 Nov
観察研究12;199(9):591-6;
discussion 581; quiz 608.

191 Clinical co-morbidities in obstructive sleep apnea syndrome treatedwithmandibular repositioning appliance.

Machado MA

Respir Med. 2006
Jun;100(6):988-95. Epub
2005 Nov 8.

非ランダム化比較試験

192 [Evaluation of effective jaw position and body posture for oral applianceof patients with obstructive sleep apnea syndrome].

Tsuda H

Nihon Hotetsu Shika
Gakkai Zasshi. 2005
Oct;49(5):736-43.

アウトカムが吸気速度

193 Surgery for obstructive sleep apnoea.

Sundaram S

Cochrane Database Syst 総論
Rev. 2005 Oct19;(4):CD001004.

194 The interaction between changes in upright mandibular position andsupine airway size in patients with obstructive sleep apnea.

Tsuiki S

Am J Orthod Dentofacial 非ランダム化比較試験
Orthop. 2005
Oct;128(4):504-12.

195 Short-term effects of a mandibular advancement device on obstructive
sleep apnoea: an open-label pilot trial.

Aarab GJ Oral Rehabil. 2005
Aug;32(8):564-70.

非ランダム化比較試験

196 [An adjustable appliance in treatment of obstructive sleep apneahypopnea syndrome].

Gao XM

Zhonghua Kou Qiang Yi
Xue Za Zhi. 2005
Mar;40(2):137-40.

非ランダム化比較試験

198 Obstructive sleep apnea patients with the oral appliance experiencepharyngeal size and shape changes in three dimensions.

Kyung SH

Angle Orthod. 2005
Jan;75(1):15-22.

非ランダム化比較試験

199 A comparison of the Twin Block and Herbst mandibular advancement
splints in the treatment of patients with obstructive sleep apnoea: aprospective study.

Lawton HM

Eur J Orthod. 2005
Feb;27(1):82-90.

評価方法がPSGではない

200 A review of surgical treatment for obstructive sleep apnoea/hypopnoea
syndrome.

McDonald JP

Surgeon. 2003
Oct;1(5):259-64.

総論

201 Oral appliances for obstructive sleep apnoea.

Lim J

Cochrane Database Syst 総論
Rev. 2004 Oct18;(4):CD004435.

203 Nasal dilator strip therapy for chronic sleep maintenance insomnia: acase series.

Krakow B

Sleep Breath. 2004
Sep;8(3):133-40.

口腔内装置についての論文ではない

204 [A trial of titration in oral appliance therapy for obstructive sleep apnea
syndrome].

Watanabe K

Kokubyo Gakkai Zasshi.
2004 Jun;71(2):95-101.

口腔内装置のタイトレーションに関する論文

205 Pilot study of a novel mandibular advancement device for the control ofsnoring.

Vanderveken OM

Acta Otolaryngol. 2004
Jun;124(5):628-33.

非ランダム化比較試験

J Orthod. 2004
Jun;31(2):115-23.

対象がOSAではない

206 Non-apneic snoring and the orthodontist: the effectiveness of mandibular Smith AM
advancement splints.

207 Efficacy of positive airway pressure and oral appliance in mild tomoderate obstructive sleep apnea.

Barnes M

Am J Respir Crit CareMed. 2004 Sep
15;170(6):656-64. Epub
2004 Jun 16.

口腔内装置とCPAPの比較である

208 Efficacy and co-morbidity of oral appliances in the treatment of
obstructive sleep apnea-hypopnea: a systematic review.

Hoekema A

Crit Rev Oral Biol Med. 総論
2004 Jun 4;15(3):137-55.

209 Use of a mandibular advancement device in patients with congestive
heart failure and sleep apnoea.

Eskafi M

Gerodontology. 2004
Jun;21(2):100-7.

非ランダム化比較試験

210 [Conservative treatment in mild obstructive sleep apnea: comparison oftheophylline and nasal continous positive airway pressure ventilation].

Rieger M

Laryngorhinootologie.
2004 May;83(5):324-9.

口腔内装置についての論文ではない

211 Quantitative polygraphic controlled study on efficacy and safety of oral
splint devices in tooth-grinding subjects.

Dube CJ Dent Res. 2004
May;83(5):398-403.

口腔内装置についての論文ではない

212 Two different degrees of mandibular advancement with a dental appliance Tegelberg A
in treatment of patients with mild to moderate obstructive sleep apnea.

Acta Odontol Scand.
2003 Dec;61(6):356-62.

評価方法がPSGではない

213 Lack of efficacy for a cervicomandibular support collar in the
management of obstructive sleep apnea.

Skinner MA

Chest. 2004
Jan;125(1):118-26.

口腔内装置についての論文ではない

214 [Treatment of the obstructive sleep-apnea syndrome in adults].

Hoekema A

Ned Tijdschr Geneeskd. 総論
2003 Dec 6;147(49):240712.

215 Identification and treatment of obstructive sleep apnea in adults andchildren with epilepsy: a prospective pilot study.

Malow BA

Sleep Med. 2003
Nov;4(6):509-15.

口腔内装置についての論文ではない

216 Preliminary findings from a prospective, randomized trial of two tonguebase surgeries for sleep-disordered breathing.

Thomas AJ

Otolaryngol Head Neck
Surg. 2003
Nov;129(5):539-46.

口腔内装置についての論文ではない

217 Oral appliances for obstructive sleep apnoea.

Lim J

Cochrane Database Syst 総論
Rev. 2003;(4):CD004435.

218 A prospective randomized study comparing two different degrees ofmandibular advancement with a dental appliance in treatment of severe
obstructive sleep apnea.

Walker-Engstrom ML Sleep Breath. 2003
Sep;7(3):119-30.

評価方法がPSGではない

219 Dental and occlusal changes during mandibular advancement splint
therapy in sleep disordered patients.

Robertson C

Eur J Orthod. 2003
Aug;25(4):371-6.

口腔内装置の副作用に関する論文

220 Dental and skeletal changes after 4 years of obstructive sleep apnea
treatment with a mandibular advancement device: a prospective,
randomized study.

Ringqvist M

Am J Orthod Dentofacial 口腔内装置の副作用に関する論文
Orthop. 2003
Jul;124(1):53-60.

221 The role of oral appliance therapy in the treatment of obstructive sleep
apnea.

Ferguson KA

Clin Chest Med. 2003
Jun;24(2):355-64.

総論

222 The role of oral appliances in treating obstructive sleep apnea.

Mohsenin N

J Am Dent Assoc. 2003
Apr;134(4):442-9.

総論

223 Effect of oral appliance therapy on upper airway collapsibility inobstructive sleep apnea.

Ng AT

Am J Respir Crit CareMed. 2003 Jul
15;168(2):238-41. Epub
2003 Apr 30.

口腔内装置の装着時と非装着時の比較である

224 Cephalometric evaluation of craniofacial and upper airway structures inJapanese patients with obstructive sleep apnea.

Endo SJ Med Dent Sci. 2003
Mar;50(1):109-20.

アウトカムがセファロ評価

225 A physiologic comparison of nasal and oral positive airway pressure.

Smith PL

Chest. 2003
Mar;123(3):689-94.

口腔内装置についての論文ではない

226 Effect of vertical dimension on efficacy of oral appliance therapy in
obstructive sleep apnea.

Pitsis AJ

Am J Respir Crit CareMed. 2002 Sep
15;166(6):860-4.

口腔内装置の開口量に関する論文

227 Randomized crossover trial of two treatments for sleep apnea/hypopnea Engleman HM
syndrome: continuous positive airway pressure and mandibular
repositioning splint.

Am J Respir Crit CareMed. 2002 Sep
15;166(6):855-9.

口腔内装置とCPAPの比較である

228 Oral appliance therapy improves symptoms in obstructive sleep apnea: a Gotsopoulos H
randomized, controlled trial.

Am J Respir Crit CareMed. 2002 Sep
1;166(5):743-8.

他の検索論文と同じデータである

229 Mandibular advancement splint improves indices of obstructive sleep
apnoea and snoring but side effects are common.

N Z Med J. 2002 Jun
21;115(1156):289-92.

評価方法がスプリットナイトPSGである

230 Cranial base considerations between apnoeics and non-apnoeic snorers, Robertson C
and associated effects of long-term mandibular advancement on condylar
and natural head position.

Eur J Orthod. 2002
Aug;24(4):353-61.

アウトカムがセファロ評価

231 An individually adjustable oral appliance vs continuous positive airway
pressure in mild-to-moderate obstructive sleep apnea syndrome.

Chest. 2002
Aug;122(2):569-75.

口腔内装置とCPAPの比較である

Neill A

Randerath WJ

232 [Success rate and complications of primary, laser-assisted uvuloplasty in Schlieper J
patients with snoring].

Mund Kiefer Gesichtschir. 口腔内装置についての論文ではない
2002 May;6(3):146-52.

233 Mandibular advancement appliances and obstructive sleep apnoea: arandomized clinical trial.

Eur J Orthod. 2002
Jun;24(3):251-62.

評価方法がPSGではない

234 Mandibular advancement splints and continuous positive airway pressure Tan YK
in patients with obstructive sleep apnoea: a randomized cross-over trial.

Eur J Orthod. 2002
Jun;24(3):239-49.

口腔内装置とCPAPの比較である

235 Continuous positive airways pressure for obstructive sleep apnoea.

White J

Cochrane Database Syst 総論
Rev. 2002;(2):CD001106.

236 A comparative study of two mandibular advancement appliances for thetreatment of obstructive sleep apnoea.

Rose E

Eur J Orthod. 2002
Apr;24(2):191-8.

２種類の口腔内装置の比較である

Thorax. 2002
Apr;57(4):305-8.

評価方法がPSGではない

Johnston CD

237 Can mandibular advancement devices be a satisfactory substitute for
Smith DM
short term use in patients on nasal continuous positive airway pressure?

238 4-year follow-up of treatment with dental appliance oruvulopalatopharyngoplasty in patients with obstructive sleep apnea: arandomized study.

Walker-Engstrom ML Chest. 2002
Mar;121(3):739-46.

口腔内装置と外科手術の比較である

239 Distraction osteogenesis in Pierre Robin sequence and related
respiratory problems in children.

Monasterio FO

J Craniofac Surg. 2002
Jan;13(1):79-83;
discussion 84.

口腔内装置についての論文ではない

240 Treatment of snoring and obstructive sleep apnea with a mandibular
protruding device: an open-label study.

Fransson AM

Sleep Breath.
2001;5(1):23-33.

非ランダム化比較試験

241 Randomized controlled study of an oral jaw-positioning appliance for the Villa MP
treatment of obstructive sleep apnea in children with malocclusion.

Am J Respir Crit CareMed. 2002 Jan
1;165(1):123-7.

対象が小児である

242 [The study on the correlation between the effect of dental appliances on Liu Y
OSAS and the morphology of upper airway and craniofacial structures].

Zhonghua Kou Qiang Yi
Xue Za Zhi. 1998
Nov;33(6):365-8.

非ランダム化比較試験

243 Cephalometric and physiologic predictors of the efficacy of an adjustable Liu Y
oral appliance for treating obstructive sleep apnea.

Am J Orthod Dentofacial 口腔内装置の治療効果予測に関する論文
Orthop. 2001
Dec;120(6):639-47.

244 Evidence-based medicine and sleep apnea.

Respir Care. 2001
Dec;46(12):1418-32;
discussion 1432-4.

Heitman SJ

総論

245 Pharyngeal airway space changes after counterclockwise rotation of the Mehra P
maxillomandibular complex.

Am J Orthod Dentofacial 口腔内装置についての論文ではない
Orthop. 2001
Aug;120(2):154-9.

246 Effects of a titratable oral appliance on supine airway size in awake non- Tsuiki S
apneic individuals.

Sleep. 2001 Aug
1;24(5):554-60.

対象がOSAではない

247 Influence of sleep posture on response to oral appliance therapy forsleep apnea syndrome.

Yoshida K

Sleep. 2001 Aug
1;24(5):538-44.

睡眠体位に関する論文

248 Sleep-disordered breathing and upper-airway anomalies in first-degree
relatives of ALTE children.

Guilleminault C

Pediatr Res. 2001
Jul;50(1):14-22.

口腔内装置についての論文ではない

249 Oral appliances for the management of severe snoring: a randomized
controlled trial.

Johnston CD

Eur J Orthod. 2001
Apr;23(2):127-34.

アウトカムがイビキ評価

250 A review of oral devices in the treatment of habitual snoring andobstructive sleep apnoea.

Lindman R

Swed Dent J.
2001;25(1):39-51.

総論

252 [Effect of an oral appliance for obstructive sleep apnea syndrome].

Takimoto K

Kokubyo Gakkai Zasshi.
2001 Mar;68(1):141-7.

非ランダム化比較試験

253 Factors related to the efficacy of an adjustable oral appliance for thetreatment of obstructive sleep apnea.

Liu Y

Chin J Dent Res. 2000
Nov;3(3):15-23.

口腔内装置の治療効果予測に関する論文

254 [A device for mandibular advancement in respiratory disorders of sleep.
Clinical study].

Bacon W

Orthod Fr. 2000
Dec;71(4):295-302.

アウトカムがセファロ評価

255 Effects of mandibular advancement on respiratory resistance.

Lorino AM

Eur Respir J. 2000
Nov;16(5):928-32.

アウトカムが呼吸抵抗

256 The effects of orthognathic surgery on pharyngeal airway dimensions and Turnbull NR
quality of sleep.

J Orthod. 2000
Sep;27(3):235-47.

口腔内装置についての論文ではない

257 Treatments for snoring: a comparison of somnoplasty and an oral
appliance.

Laryngoscope. 2000
口腔内装置と外科手術の比較である
Oct;110(10 Pt 1):1680-3.

Cartwright R

258 Quality of life assessment of treatment with dental appliance or UPPP in Walker-Engstrom ML J Sleep Res. 2000
patients with mild to moderate obstructive sleep apnoea. A prospective
Sep;9(3):303-8.
randomized 1-year follow-up study.

口腔内装置と外科手術の比較である

259 [Drug therapy for sleep apnea syndrome].

Takahashi Y

Nihon Rinsho. 2000
Aug;58(8):1671-4.

総論

260 A randomized, controlled crossover trial of two oral appliances for sleep
apnea treatment.

Bloch KEAm J Respir Crit CareMed. 2000
Jul;162(1):246-51.

２種類の口腔内装置の比較である

261 [Treatment of sleep apnea syndromes].

Tardif C

Presse Med. 2000 May
総論
27-Jun 3;29(19):1083-90.

262 [Use of an intraoral snoring therapy device of thermolabile plastic].

Maurer JT

HNO. 2000 Apr;48(4):302- 口腔内装置が基準を満たさない
8.

263 Continuous positive airways pressure for obstructive sleep apnoea.

Wright J

Cochrane Database Syst 総論
Rev. 2000;(2):CD001106.

264 Dose-dependent effects of mandibular advancement on pharyngeal
mechanics and nocturnal oxygenation in patients with sleep-disorderedbreathing.

Kato J

Chest. 2000
Apr;117(4):1065-72.

評価方法がPSGではない

265 Effects and adverse events of a dental appliance for treatment of
obstructive sleep apnoea.

Tegelberg A

Swed Dent J.
1999;23(4):117-26.

口腔内装置と外科手術の比較である

266 A prospective randomized study of a dental appliance compared with
Wilhelmsson B
uvulopalatopharyngoplasty in the treatment of obstructive sleep apnoea.

Acta Otolaryngol.
1999;119(4):503-9.

口腔内装置と外科手術の比較である

267 Anterior-inferior mandibular osteotomy in treatment of obstructive sleep Krekmanov L
apnea syndrome.

Int J Adult Orthodon
Orthognath Surg.
1998;13(4):289-98.

口腔内装置についての論文ではない

268 Cervical headgear therapy as a factor in obstructive sleep apnea
syndrome.

Pirila-Parkkinen K

Pediatr Dent. 1999 JanFeb;21(1):39-45.

口腔内装置についての論文ではない

269 Comparisons of oral devices for snoring.

Eckhart JE

J Calif Dent Assoc. 1998 総論
Aug;26(8):611-23.

270 Pilot study of a semi-flexible intra-oral appliance for the control ofsnoring.

Cameron DA

Br Dent J. 1998 Sep
26;185(6):304-7.

非ランダム化比較試験

271 Obstructive sleep apnea: oral appliance therapy and severity of condition. Cohen R

Oral Surg Oral Med Oral 非ランダム化比較試験
Pathol Oral Radiol Endod.
1998 Apr;85(4):388-92.

272 Mandibular advancement devices for the control of snoring.

Stradling JR

Eur Respir J. 1998
Feb;11(2):447-50.

評価方法がPSGではない

273 The effect of a mandibular advancement device on apneas and sleep inpatients with obstructive sleep apnea.

Marklund M

Chest. 1998
Mar;113(3):707-13.

非ランダム化比較試験

274 Comparison of two dental devices for treatment of obstructive sleep
apnea syndrome (OSAS).

Hans MGAm J Orthod Dentofacial 評価方法がPSGではない
Orthop. 1997
May;111(5):562-70.

275 A short-term controlled trial of an adjustable oral appliance for thetreatment of mild to moderate obstructive sleep apnoea.

Ferguson KA

Thorax. 1997
Apr;52(4):362-8.

口腔内装置とCPAPの比較である

276 [Mechanical/prosthetic protrusion of the mandible: effects on thepharynx].

Hochban W

Pneumologie. 1996
Dec;50(12):919-23.

アウトカムがセファロ評価

277 Oral appliance therapy for the treatment of obstructive sleep apnea.

Fleetham JA

Sleep. 1996 Dec;19(10Suppl):S288-90.

総論

278 The cephalometric morphology of patients with obstructive sleep apnoea Battagel JM(OSA).

Eur J Orthod. 1996
Dec;18(6):557-69.

アウトカムがセファロ評価

279 The effect of the tongue retaining device on awake genioglossus muscle
activity in patients with obstructive sleep apnea.

Am J Orthod Dentofacial 口腔内装置が基準を満たさない
Orthop. 1996
Jul;110(1):28-35.

Ono T

280 A crossover study comparing the efficacy of continuous positive airway
pressure with anterior mandibular positioning devices on patients with
obstructive sleep apnea.

Clark GT

Chest. 1996
Jun;109(6):1477-83.

口腔内装置とCPAPの比較である

281 A randomized crossover study of an oral appliance vs nasal-continuous
positive airway pressure in the treatment of mild-moderate obstructive
sleep apnea.

Ferguson KA

Chest. 1996
May;109(5):1269-75.

口腔内装置とCPAPの比較である

282 Dental appliances in the treatment of snoring. A comparison between an Marklund M
activator, a soft-palate lifter, and a mouth-shield.

Swed Dent J.
1996;20(5):183-8.

３種類の口腔内装置の比較である

283 Cephalometric predictors for orthopaedic mandibular advancement inobstructive sleep apnoea.

Mayer G

Eur J Orthod. 1995
Feb;17(1):35-43.

アウトカムがセファロ評価

284 Mandibular advancement splint: an appliance to treat snoring andobstructive sleep apnea.

O'Sullivan RA

Am J Respir Crit CareMed. 1995
Jan;151(1):194-8.

対象にOSA以外の患者が含まれている

285 Mandibular advancement with dental appliances in obstructive sleep
apnoea.

Sjoholm TT

J Oral Rehabil. 1994
Sep;21(5):595-603.

評価方法がPSGではない

286 Clinical trial of an oral vestibular shield for the control of snoring.

Veres EJ Dent Assoc S Afr. 1993 口腔内装置についての論文ではない
Jan;48(1):15-7.

287 Obligatory nasal breathing: effects on snoring and sleep apnoea.

Bushell MK

Med J Aust. 1991 Jul
15;155(2):83-5.

口腔内装置についての論文ではない

288 Verification of sleep apnea using a portable sleep apnea screening
device.

Emsellem HASouth Med J. 1990
Jul;83(7):748-52.

口腔内装置についての論文ではない

論文名
1 長崎大学歯学部における5年次統合科目での睡眠学の講義の現状と問
題点

著者
鮎瀬 卓郎

詳細

除外理由

日本歯科医学教育学会
雑誌(0914-5133)
2015.04;31(1);3-9

口腔内装置についての論文ではない

2 閉塞型睡眠時無呼吸症候群患者に対する口腔内装置の適切な下顎開口 西川 葵
量の検討

日本補綴歯科学会誌(1883-4426)
2015.01;7(1);46-54

アウトカムが鼻腔通気度

3 新潟大学医歯学総合病院口腔外科いびき外来受診患者の臨床的検討

上杉 崇史

日本口腔科学会雑誌(0029-0297)
2014.07;63(3);251-259

非ランダム比較試験

4 いびきや無呼吸を主訴に当科を受診する患者の実態調査

山川 道代

Dental Medicine
Research(1882-0719)
2013.07;33(2);198-204

非ランダム比較試験

5 閉塞性睡眠時無呼吸症候群に対する口腔内装置が睡眠の質へ及ぼす
影響

有坂 岳大

日本口腔外科学会雑誌(0021-5163)
2013.05;59(5);294-300

非ランダム比較試験

6 喉頭および喉頭周辺疾患の呼吸生理と睡眠呼吸障害 呼吸様式の変化 竹野 研二に伴う上気道形態の変化 睡眠ファイバーとMDCT画像解析による検討

喉頭(0915-6127)
2010.12;22(2);88-92

口腔内装置についての論文ではない

7 睡眠時無呼吸症候群患者における顎顔面形態の矯正学的検討と治療効 及川 由紀子
果に対する認識の調査

東北矯正歯科学会雑誌(1340-2668)
2009.12;17(1);3-10

非ランダム比較試験

8 岩手医科大学附属病院歯科医療センター『いびき・歯ぎしり外来』におけ 三條 晃
る睡眠時無呼吸低呼吸症候群患者の治療について(第一報) 患者および治療の特徴について

東北矯正歯科学会雑誌(1340-2668)
2008.12;16(1);5-12

非ランダム比較試験

9 閉塞型睡眠時無呼吸-呼吸低下症候群患者における口腔装置が頭頸位 Inoko Yoshimiに及ぼす影響(Influence of oral appliances on craniocervical posture in
obstructive sleep apnea-hypopnea syndrome patients)

Journal of Prosthodontic アウトカムがセファロ評価
Research(1883-1958)
2009.07;53(3);107-110

10 閉塞型睡眠時無呼吸症候群に用いられるオーラルアプライアンスに付与 伊藤 利実
する下顎位に関する検討

東北大学歯学雑誌(0287- 対象がOSAではない3915) 2009.06;28(1);T33T43

11 閉塞型睡眠時無呼吸症候群における口腔内装具治療による短期間副作 Nakamura Shuhei
用の主観的及び客観的評価 予備的研究(Subjective and objective
assessments of short-term adverse effects induced by oral appliancetherapy in obstructive sleep apnea: A preliminary study)

Journal of Medical and
Dental Sciences(13428810) 2009.03;56(1);3748

対象がOSAではない

12 当科における閉塞型睡眠時無呼吸症候群患者に対する取り組みについ 博多 研文て栃木県歯科医学会誌
2008.08;60;3-7

アウトカムがセファロ評価

13 OSAS治療用口腔内装置装着が男女の咀嚼関連筋活動に及ぼす影響齊藤 邦子

日大歯学(0385-0102)
2008.06;82(2);163-169

対象がOSAではない

14 OSAS治療用口腔内装置装着が咀嚼関連筋活動に及ぼす影響 咬合挙 塩田 洋平
上量5.0mm

日大歯学(0385-0102)
2008.06;82(2);115-122

対象がOSAではない

15 閉塞型睡眠時無呼吸症候群治療用口腔内装置が顎口腔系に与える影響 塩田 洋平
咬合日本補綴歯科学会雑誌(0389-5386)
2008.01;52(1);59-67

対象がOSAではない

16 歯科口腔器具を装着した閉塞性睡眠時無呼吸症候群患者における下顎 Inoko Yoshimi
位置と口咽頭空間との関係(Relationship between Mandibular Position
and Oropharyngeal Space in Obstructive Sleep Apnea Syndrome Patientswith Dental Oral Appliance)

Prosthodontic Research& Practice(1347-7021)
2007.07;6(3);194-199

治療評価がPSGではない

17 過去10年ごとにみた高齢初診患者の変化

老年歯科医学(0914口腔内装置についての論文ではない
3866) 2007.03;21(4);397402

田岡 法一

18 閉塞性睡眠時無呼吸症候群患者における側方頭部X線規格写真を用い 臼井 聡美
た形態学的分析

トヨタ医報(1343-9685)
2006.10;16;66-73

治療評価がPSGではない

19 閉塞性睡眠時無呼吸患者における口腔内装具の有効性の評価 頭部計 Saito Tomokatsu
測による研究(Predictors of oral appliance efficacy in patients with
obstructive sleep apnea: A cephalometric study)

横浜医学(0372-7726)
2006.03;57(1～2);1-8

非ランダム比較試験

20 閉塞型睡眠時無呼吸症候群の口腔内装置に有効な下顎位および体位の 津田 緩子
検討

日本補綴歯科学会雑誌(0389-5386)
2005.10;49(5);736-743

アウトカムが吸気速度

21 睡眠時無呼吸症候群に対するチーム医療の取り組み

臨床精神医学(0300非ランダム比較試験
032X)
2004.10;33(10);1373-1382

土生川 光成