15 (Tue)プログラム

November
9:00
Door Open

Program

9:30 - 9:40

〈Medium Hall〉

Opening Remarks
Hiroyuki KAMIYA

President, JEMS 51th Annual Meeting
Hiroshima University
受賞講演

9:40 - 9:55

〈Medium Hall〉

JEMS 51 President's Lecture

Symposium 1〈Medium Hall〉

Genome Functional Integrity

シンポジウム

10:00 - 12:00

Chairs: Isao KURAOKA（Fukuoka University）
Yuji MASUDA（Nagoya University）

10:00

Resistance to chemical carcinogenesis induction in the longest-lived rodent, thenaked mole-rat
Kyoko MIURA
Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University

S1-2

10:22

APOBEC mutagenesis associated with human papillomavirus carcinogenesis

Pathogen Genomics Center, National Institute of Infectious Diseases

10:44

Genomic, biochemical, and structural bases of an mRNA-selective naturaltranslation inhibitor
Shintaro IWASAKI1, 2

研究会 定例会

Iwao KUKIMOTO
S1-3

e

ポスター

S1-1

1

RIKEN Cluster for Pioneering Research,
Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences,
The University of Tokyo

2

11:06

Aberrant RNA Splicing as a New Hallmark of Cancer development
Akihide YOSHIMIDivision of Cancer RNA Research, National Cancer Center Research Institute

11:28

Discussion

11:50

DNA demethylating agents suppress the growth of cancer cells through theactivation of retrotransposons
Hitoshi OHTANI
Graduate School of Bioagricultural Sciences, Nagoya University

33

人名索引

S1-5

ワークショップ

S1-4

プログラム13:20 - 14:00〈Web〉

ePoster (Online Poster Session)
		

13:20

Program

14:10 - 15:00[Odd number of P01-33] Core time 1〈Medium Hall〉

General Meeting & Awards Ceremony

受賞講演

15:00 - 16:40〈Medium Hall〉

Award Lecture
Chair: Masami YAMADA（National Defense Academy of Japan）
JEMS Award 2022

シンポジウムAW

15:00

Studies on carcinogenic activity of the combination of a colonic non-carcinogenic
mutagen and colitis inducer
Atsushi HAKURA
Global Drug Safety, Eisai Co.,Ltd.

JEMS Encouragement Award 2022

EA-1

15:30

ポスター

e

Molecular mechanisms of mutagenesis and genomic instability caused byribonucleotides incorporated into DNA
Akira SASSA
Department of Biology, Graduate School of Science, Chiba University

JEMS Encouragement Award 2022

EA-2

15:50

The mechanism of radiation-induced tumorigenesis using in vivo model研究会 定例会

Megumi SASATANI

Research Institute for Radiation Biology and Medicine, Hiroshima University
JEMS Service Award 2022

SA

16:10

Investigation of antimutagenic and photomutagenic substances
Sakae ARIMOTO

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ワークショップ

16:50 - 17:30〈Web〉

ePoster (Online Poster Session)
		

16:50

[Even number of P02-34] Core time 2

人名索引

34

16 (Wed)

プログラム

November
8:40
Door Open

Program

9:00 - 9:40

〈Web〉

ePoster (Online Poster Session)
		

9:00

Symposium 2

受賞講演

9:50 - 11:50[Odd number of P35-65] Core time 3〈Medium Hall〉

New Modalities and Regulatory Science

S2-1

9:50

Case Studies in Safety Evaluation for New Modalities
Chinami ARUGA

Safety Research Laboratories, Mitsubishi Tanabe Pharma Corporation

S2-2

10:12

シンポジウムChairs: Katsuhito KINO（Tokushima Bunri University）
Akira TAKEIRI（Chugai Pharmaceutical Co., Ltd.）

Safety of genome editing and mutation research

Takayoshi SUZUKI

Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences

10:34

Current issues on quality and safety assessment of cell-based therapeutic products
Satoshi YASUDA
Division of Cell-Based Therapeutic Products, National Institute of Health Sciences

S2-4

10:56

Department of Biology, Graduate School of Science, Chiba University

11:18

Discussion

11:40

12:00 - 12:40

Analytical and diagnostic methods based on single molecule fluorescent blinking
observation
Kiyohiko KAWAISANKEN, Osaka University

ワークショップ

S2-5

〈Web〉

ePoster (Online Poster Session)
		

12:00

研究会 定例会

Understanding the molecular basis of nucleic acid-induced innate immunity usinga DNA repair-deficient model
Akira SASSA

e

ポスター

S2-3

[Even Number of P36-66] Core time 4
人名索引

35

プログラム13:50 - 15:50
Symposium 3〈Medium Hall〉

New Development of Radiation Effects Research from the
Perspective of Genome Analysis
Chairs: Asao NODA（Radiation Effects Research Foundation）
Masahiko WATANABE（Shujitsu University）

S3-1

13:50

ProgramDirect observation of DNA damage caused by mutagens and radiation using
atomic force microscopy
Toshiaki NAKANO1, Ken AKAMATSU1, Masataka TUDA2, Hiroshi IDE2,
Naoya SHIKAZONO1
1National Institutes for Quantum Science and Technology (QST),
Graduate School of Integrated Sciences for Life, Hiroshima University

2

S3-2

14:12

Germline de novo mutations and radiation effects

Arikuni UCHIMURA, Yasunari SATOH
受賞講演

Radiation Effects Research Foundation

S3-3

14:34

Frequencies and characteristics of somatic mutations in hematopoietic stem cells
from mice exposed to X-ray radiation
Osamu TANABE, Yukiko MATSUDA
Radiation Effects Research Foundation

シンポジウム

S3-4

14:56

Characteristic genetic abnormalities revealed by genomic analysis of radiationinduced cancer
Kazuhiro DAINO1, Hirotaka TACHIBANA1, 2, Atsuko ISHIKAWA1, Kenshi SUZUKI1,
Takamitsu MORIOKA1, Tatsuhiko IMAOKA1, Shizuko KAKINUMA1
1

National Institutes for Quantum Science and Technology,
Department of Biology, Graduate School of Science, Chiba university

2

S3-5

15:18

Epidemiological study of atomic bomb survivors

Ritsu SAKATA
ポスター

eDiscussion

15:40

16:00 - 16:15

Radiation Effects Research Foundation〈Medium Hall〉

研究会 定例会

The Best Presentation Awards Ceremony & Closing Remarks

ワークショップ
人名索引36

November 15 (Tue)

Poster View and Web Chat Time: 2022 November 9 (Wed)- November 18 (Fri)プログラム

ePoster (Online Poster Session)

Poster Discussion:【Core time 1】November 15 (Tue), 13:20-14:00【P01-33 for odd number】
                           【Core time 2】November 15 (Tue), 16:50-17:30【P02-34 for even number】

P-01

Reconsideration of bladder-specific carcinogenicity of BBN - Genotoxicity evaluation of major
metabolite BCPN using gpt delta mice
Yoshiya YAMAMURA, Yuzoh TAKEZAWA, Misaki ABE, Naofumi TAKAHASHI,
Chinatsu FUJIWARA, Shinya MIYAZAKI, Kunio WADA

P-02

Investigation of the measurement conditions in a GLP-applied rat micronucleus assay using aflow cytometer
Akihiro KAWADE1, Naoki KOYAMA2, Rika SATO1, Masaki KURAKAMI2, Takeshi YAMAGATA1,
Dai KAKIUCHI2, Atsushi HAKURA2, Tomomi SHIBATA1, Kenichi NORITAKE1, Shoji ASAKURA2

受賞講演

The Institute of Environmental Toxicology

Program

Mutagenicity and genotoxicity

1

Sunplanet Co., Ltd., 2Eisai Co., Ltd.

Impact of endogenous oxidative DNA damage in germline mutations: study from repairdeficient mice
Mizuki OHNO1, Noriko TAKANO2, Fumiko SASAKI1, Kyoko HIDAKA3
1

Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University,
Fac. of Design, Kyushu Univ., 3 Ctr. Fundam. Ed., Univ. of Kitakyushu

シンポジウム

P-03

2

P-04

1

Sch. Pharm. Sci., Hiroshima Univ., 2Grad. Sch. Biomed. Hlth. Sci., Hiroshima Univ.

P-05

Study on the mechanism of large micronucleus induction by acetamide in rat hepatocytes

e

ポスター

Development of a high-throughput mutagenesis assay with supF gene and Next Generation
Sequencer
Ren IWATA1, Hidehiko KAWAI1, 2, Hiroyuki KAMIYA1, 2

Norifumi TAKIMOTO1, 2, Yuji ISHII1, Tatsuya MITSUMOTO1, Moeka NAMIKI1, Shinji TAKASU1,
Makoto SHIBUTANI2, Kumiko OGAWA1
1

P-06

Detection of genotoxic reactions through directly analyzing DNA damage responses onchromatin fraction
Katsuyoshi HORIBATA, Kei-ichi SUGIYAMA

研究会 定例会

Division of Pathology, National Institute of Health Sciences,
Laboratory of Veterinary Medicine, Tokyo University of Agriculture and Technology

2

Division of Genetics and Mutagenesis, National Institute of Health Sciences

Formaldehyde induces premature senescence and delayed nucleotide excision repair

Takashi SUZUKI, Yukako KOMAKI, Yuko IBUKI

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

P-08

A novel mechanism of γ-H2AX induction via nuclease release from endoplasmic reticulum

Yuta MORI1, Yukako KOMAKI1, Tatsushi TOYOOKA2, Yuko IBUKI1

ワークショップ

P-07

1

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka,
National Institute of Occupational Safety and Health2

Improvement of bioassay for detecting nuclear receptor ligand activity using yeast protoplasts

Yuto HANAICHI1, Yuya FUJITA2, Sayoko HARASHIMA2, Honami ONISHI2, Kentaro MORI2,
Mami MATANO2, Takashi YAGI1, Masanobu KAWANISHI1
1

Department of Biochemistry, Graduate School of Science, Osaka Metropolitan University,
Department of Natural Science, Faculty of Life and Environmental Sciences, Osaka Prefecture University

2

37

人名索引

P-09

P-10
プログラム

Evaluation of cyto- and geno-toxicities induced by enteric bacteria isolated from a Japanesecolorectal cancer patient using DNA cross link repair deficient cells
Osamu TSUBOHIRA1, Ai UESHIMA1, Yuta HISATOMI1, Yoshimitsu ODA1, Yuta TSUNEMATSU2,
Michio SATO2, Yuichiro HIRAYAMA2, Noriyuki MIYOSHI3, Yuji IWASHITA4, Yuko YOSHIKAWA5,
Haruhiko SUGIMURA4, Yukari TOTSUKA6, Keiji WAKABAYASHI3, Kenji WATANABE2,
Masanobu KAWANISHI1
1

Graduate School of Science, Osaka Metropolitan University, 2Pharmacy Department, University of Shizuoka,
Department of Food and Nutrition, University of Shizuoka,
4
Medical Faculty, Hamamatsu University School of Medicine,5
Veterinary Department, Nippon Veterinary And Life Science University, 6National Cancer Center Research Institute3

ProgramP-11

Examination of automated growth inhibition identification in Ames test by machine-learning
Rise KUM, Kyoka KAIYA, Hiroshi ITO
Scientific Product Assessment Center, Japan Tobacco Inc.

P-12
受賞講演

Comparison of intra-day variability of response and response to weak mutagens between the
24-well Ames test and conventional method using tobacco extracts
Yasunori TAKAHASHI, Toru ISHII, Yuka SAKAI, Kyoka KAIYA, Rise KUM, Eri KAWAGUCHI,Emi KUMAGAI, Yuka TSUTSUMI, Tsuneo HASHIZUME, Toshiro FUKUSHIMA
Scientific Product Assessment Center, Japan Tobacco Inc.

P-13

Dietary lipids as a source of etheno-DNA damage

Petr GRUZ1, Masatomi SHIMIZU2, Ayako DAIZO3, Kenichi KAWADA2, Masami YAMADA4,
Masamitsu HONMA5, Katsuyoshi HORIBATA1, Kei-ichi SUGIYAMA1
シンポジウム1

Division of Genetics and Mutagenesis, National Institute of Health Sciences,
Division of Medical Nutrition, Tokyo Healthcare University, 3Department of Human Nutrition, Seitoku University,
4
National Defense Academy, 5National Institute of Health Sciences2

P-14

Mutations and DNA adducts induced by aristolochic acid
Masami YAMADA1, Daichi KOYABU1, Yang LUAN2, Takayoshi SUZUKI3
1

Department of Applied Chemistry, National Defense Academy, 2Shanghai Jiao Tong University School of Medicine,National Institute of Health Sciences

3

ポスター

e

Organic, biological or computational chemistry of mutagens
P-15

Ames mutagenicity investigation for 15 aromatic or cyclic N -nitroso compounds

Ayako FURUHAMA1, Kei-ichi SUGIYAMA1, Masamitsu HONMA2
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences (NIHS),
National Institute of Health Sciences (NIHS)

2

研究会 定例会

Molecular biology of mutagens
P-16

Analysis of the mechanism of DNA double-strand break-inducing effect of quercetin, a foodderived flavonoid
Yuduki SOMEYA1, Sakine KOBAYASHI2, Shinta SAITO3, Shigeki TAKEDA1, 2, Noritaka ADACHI3,
Aya KUROSAWA1, 2, 3, 4
1

ワークショップ

Grad. Sch. Sci. Tech., Gunma Univ., 2Sch. Sci. Tech., Gunma Univ., 3Grad. Sch. Nanobiosci., Yokohama City Univ.,
Gunma Univ. Cent. Food Sci. Wellness, Gunma Univ.

4

P-17

APOBEC3B is involved in the action-at-a-distance mutations by riboguanosine incorporated
into DNA
Kiyoharu YASUI, Tetsuya SUZUKI, Hiroyuki KAMIYA
Graduate School of Biomedical and Health Sciences, Hiroshima University

P-18
人名索引

Involvement of uracil DNA glycosylase on the action-at-a-distance mutations by 8-oxo-7,8dihydroguanine
Saho YOSHIDA, Tetsuya SUZUKI, Hiroyuki KAMIYA
Graduate School of Biomedical and Health Sciences, Hiroshima University

38

P-19

Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University

P-20

Suppression Mechanism of Genome Instability by Deaminated Nucleotides in Saccharomyces
cerevisiae
Tatsuo NUNOSHIBA1, Akira MURATA1, Yohei SUGIMOTO1, Kenshiro NISHIHARA1, 2, 3,
Miki NISHIMURA1
1
3

P-21

Repair mechanism of DNA double-strand breaks induced by accumulation of ribonucleotides
in the genome
Yuiko MAYUZUMI1, Ken TAKAFUJI1, Asuka TACHIKAWA1, Kazuma NAKATANI2, Manabu YASUI3,
Masamitsu HONMA3, Kei-ichi SUGIYAMA3, Kaoru SUGASAWA4, Kiyoe URA1, Akira SASSA1

ProgramInternational Christian University, 2Graduate School of Medicine, Juntendo University,
National Cancer Center Institute for Cancer Control

プログラム

Repair pathways for radiation DNA damage under normoxic and hypoxic conditions:
Assessment with a panel of repair-deficient human TK6 cells
Naoto SHIMIZU, Masataka TSUDA

1

P-22

1

Graduate School of Science, Chiba University, 2Tokyo Laboratory, BoZo Research Center Inc.,
Graduate School of Medical and Pharmaceutical Sciences, 4Biosignal Research Center, Kobe University

3

P-23

Coordination between excision reaction and synthesis reaction
Aya YOSHIDA, Akane MATSUMOTO, Isao KURAOKA

シンポジウムQuantitative evaluation of endogenous DNA double-strand breaks by multi-parametricanalyses of γH2AX
Asuka TACHIKAWA1, Yui YOSHIMOTO2, Ken TAKAFUJI1, Yuiko MAYUZUMI1,
Kazuma NAKATANI3, Maki NAKAMURA2, Takayuki FUKUDA2, Kaoru SUGASAWA4, Kiyoe URA1,
Akira SASSA1

受賞講演

Graduate School of Science, Chiba University,
Graduate School of Medical and Pharmaceutical Sciences, Chiba University,
3
Division of Genetics and Mutagenesis, National Institute of Health Sciences,
4
Biosignal Research Center, Kobe University
2

Department of Chemistry, Faculty of Science, Fukuoka University

Functional analysis of Human Endonuclease V

Kazuma MITSUOKA, Isao KURAOKA

Department of Chemistry, Faculty of Science, Fukuoka University

P-25

e

ポスター

P-24

Ubiquitin-mediated functional regulation of RTEL1 in the maintenance of genome stability

Remi TAMEDA, Isao KURAOKA, Arato TAKEDACHI

Department of Chemistry, Faculty of Science, Fukuoka University

P-26

The effect of age at exposure on radiation-induced tumorigenesis using mouse models

Megumi SASATANI, Kenji KAMIYA

研究会 定例会

Carcinogenesis

Research Institute for Radiation Biology and Medicine, Hiroshima University

In vivo reporter gene mutation assay for a cancer-prone liver lobe in furan-induced
hepatocarcinogenesis in rats
Daisuke HIBI1, 2, Shinji TAKASU1, Yuji ISHII1, Takashi UMEMURA1, 3
1

Division of Pathology, National Institute of Health Sciences,
Safety Research Laboratories, ONO Pharmaceutical Co.,Ltd.,
3
Graduate School of Animal Health Technology, Yamazaki University of Animal Health Technology
2

ワークショップ

P-27

Antimutagenesis and anticarcinogenesis

Mutagenicity, and correlations between antimutagenicity, radical scavenging activity, andphenolics in edible berry juices
Sakae ARIMOTO, Jun TAKATA
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

39

人名索引

P-28

New technology
プログラム

P-29

A genome sequencing-based mutagenicity evaluation method using human cells; Examination
to reduce error frequency under Hawk-Seq™ analysis
Sayaka HOSOI, Takako HIROSE, Shoji MATSUMURA, Naohiro IKEDA, Masayuki YAMANE
R&D, Safety Science Research, Kao Corporation

P-30

Evaluation of the error-corrected sequencing-based mutagenicity assay using gpt delta mice

Program

Shoji MATSUMURA1, Sayaka HOSOI1, Takako HIROSE1, Yuki OTSUBO1, Naohiro IKEDA1,
Masayuki YAMANE1, Takayoshi SUZUKI2, Kenichi MASUMURA3, Kei-ichi SUGIYAMA4
1

R&D, Safety Science Research, Kao Corporation,
Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences,
3
Division of Risk Assessment, National Institute of Health Sciences,
4
Division of Genetics and Mutagenesis, National Institute of Health Sciences2

P-31

A pipeline for de novo mutation detection – using oxidative DNA damage repair-deficient mice

Kyoko HIDAKA1, Noriko TAKANO2, Fumiko SASAKI3, Mizuki OHNO3

受賞講演

1

Ctr. Fundam. Ed., Univ. of Kitakyushu, 2Fac. of Design, Kyushu Univ.,
Dept. Med. Biophys. & Radiat. Biol., Med. Sci., Kyushu Univ.

3

Environmental pollution
P-32

Development of a yeast reporter gene assay to detect ligands of freshwater cladoceran Daphnia
magna ultraspiracle, a homolog of vertebrate retinoid X receptors

シンポジウムSayoko ITO-HARASHIMA1, 2, Yumiko TSUBOUCHI1, Eiji TAKADA1, Masanobu KAWANISHI1, 3,
Takashi YAGI1, 3
1

Department of Biological Science, Graduate School of Science, Osaka Prefecture University,
Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University,
3
Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University
2

Others
P-33

ポスター

e

Collaborative study of thresholds for mutagens: thresholds in the micronucleus test

Shizuyo SUTOU1, Akiko KOEDA2, Kana KOMATSU2, Toshiyuki SHIRAGIKU3, Hiroshi SEKI4,
Toshiyuki KUDO1
1

Shujitsu University, 2Ina Research Inc., 3Otsuka Pharmaceutical Co., Ltd., 4BML Inc.

P-34
研究会 定例会

The molecular mechanism of recognition of snake venom phosphodiesterase against cyclic
DNA substrates
Narumi AOKI-SHIOI, Ryosuke SHIKASHO, Daiki MIHARA, Isao KURAOKA
Department of Chemistry, Faculty of Science, Fukuoka University

ワークショップ
人名索引40

November 16 (Wed)Poster View and Web Chat Time: 2022 November 9 (Wed)- November 18 (Fri)プログラム

ePoster (Online Poster Session)

Poster Discussion:【Core time 3】November 16 (Wed), 9:00-9:40【P35-65 for odd number】
                           【Core time 4】November 16 (Wed), 12:00-12:40【P36-66 for even number】

P-35

Mechanisms of site-specific tumorigenesis in the rat kidney treated with madder color

Program

Mutagenicity and genotoxicity

Tatsuya MITSUMOTO1, 2, Yuji ISHII1, Norifumi TAKIMOTO1, 3, Shinji TAKASU1, Moeka NAMIKI1,
Takashi UMEMURA2, Takehiko NOHMI1, Kumiko OGAWA1
1

P-36

Transgenerational Epigenetic Inheritance (TEI) and activation of aromatic hydrocarbon
receptors (AhRs) by polycyclic aromatic hydrocarbon compounds (PAHs)
Yukiharu HORIYA

受賞講演

Division of Pathology, National Institute of Health Science,
Faculty of Animal Health Technology, Yamazaki University of Agriculture and Technology,
3
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
2

Laboratory of Environmental Epigenetics

Effects of expression level of base excision repair enzyme OGG1 on action-at-a-distancemutation induced by 8-oxo-7,8-dihydroguanine
Masano TAGA1, Tetsuya SUZUKI1, 2, Hiroyuki KAMIYA1, 2
1

School of Pharmaceutical Sciences, Hiroshima University,
Graduate School of Biomedical and Health Sciences, Hiroshima University

2

P-38

1

Div. Genetics & Mutag., NIHS, 2Lab. Proteome Res., NIBIOHN, 3Div. Mol. Target & Gene Therapy Prod., NIHS,
Div. Gen. Affairs, NIHS

4

P-39

e

ポスター

Trials and issues of an integrated in vitro genotoxicity test by toxicoproteomics using the data
independent acquisition method
Manabu YASUI1, Akiko UKAI1, Jun ADACHI2, Takayoshi SUZUKI3, Masamitsu HONMA4,
Keiichi SUGIYAMA1

シンポジウム

P-37

Analysis of mutations in male germ cells and offspring of acrylamide-treated gpt delta mice

Kenichi MASUMURA1, Tomoko ANDO2, Yuji ISHII3, Kei-ichi SUGIYAMA2
Division of Risk Assessment, National Institute of Health Sciences,
Division of Genetics and Mutagenesis, National Institute of Health Sciences,
3
Division of Pathology, National Institute of Health Sciences2

P-40

Copper-mediated DNA damage caused by purpurin, a natural anthraquinone
Hatasu KOBAYASHI1, Yurie MORI1, 2, Ryo IWASA1, Yuichiro HIRAO1, 3, Shinya KATO4,
Shosuke KAWANISHI5, Mariko MURATA1, Shinji OIKAWA1

研究会 定例会

1

1

P-41

Development of an epi-genotoxicity assay detecting chromatin modifications

Aoshi KITAMURA1, Haruto YAMADA1, Ken TAKAFUJI1, Mizuki ODAGIRI1, Manabu YASUI2,
Masamitsu HONMA2, Kei-ichi SUGIYAMA2, Kiyoe URA1, Akira SASSA1

ワークショップ

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine,
Faculty of Pharmacy, Gifu University , 3Mie Prefectural College of Nursing,4
Radioisotope Experimental Facility, Advanced Science Research Promotion Center, Mie University,
5
Faculty of Pharmaceutical Science, Suzuka University of Medical Science2

1

Graduate School of Science, Chiba University,
Division of Genetics and Mutagenesis, National Institute of Health Sciences2

Increases of genotoxicity of carbon-based nanomaterials with UV irradiation

Natsumi MIZOBATA1, Ayano MIYATA2, Kotori MIYAI2, Masanobu KAWANISI1
1

Department of Biological Chemistry, Osaka Metropolitan University,
Department of Biological Science , Osaka Prefecture University

2

41

人名索引

P-42

P-43
プログラム

Study on a novel pathway of DNA interstrand cross-link formation mediated by alcohol
dehydrogenase (ADH)
Yuya FUJITA1, Jun NAKAMURA2, Zhenfa ZHANG3, Tomonari MATSUDA4, Minoru TAKATA5,
Masanobu KAWANISHI1
1

Laboratory of Environmental Molecular Toxicology, Graduate School of Science, Osaka Metropolitan University,
Graduate School of Veterinary Science, Osaka Metropolitan University,
3
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill,
4
Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University,
5
Graduate School of Biostudies, Kyoto University
2

Program

P-44

Study on unsubstituted etheno-DNA adducts formed by lipid-derived aldehydes

Yuma NAGUMO, Yusuke HATAKAWA, Seon Hwa LEE, Tomoyuki OE
Graduate School of Pharmaceutical Sciences, Tohoku University

P-45

受賞講演

Micronucleus test using a three-dimensional human airway model: Investigation of
fundamental treatment conditions and evaluation of well-known genotoxicants requiring
metabolism
Satoru MUNAKATA, Taku WATANABE, Tomohiro TAKAHASHI, Shiori KIMURO,
Tsuneo HASHIZUME
Japan Tobacco Inc. Scientific Product Assessment Center

P-46

DNA adductome analysis for human tissues using mass spectrometry

シンポジウムYuji IWASHITA1, Shunsuke OHTSUKA1, Ippei OHNISHI1, Yuto MATSUSHITA1,
Takashi YAMASHITA1, Hideto OCHIAI2, Keigo MATSUMOTO2, Nobuhito KURONO3,
Yoshitaka MATSUSHIMA4, Hiroki MORI5, Shioto SUZUKI2, Shohachi SUZUKI2,
Fumihiko TANIOKA2, Haruhiko SUGIMURA1
1

Department of Tumor Pathology, Hamamatsu University School of Medicine, 2Iwata City Hospital,
Department of Chemistry, Hamamatsu University School of Medicine,
4
Department of Agricultural Chemistry, Tokyo University of Agriculture, 5Hamamatsu Medical Center
3

Organic, biological or computational chemistry of mutagens
P-47

Application of quantum mechanics to QSAR expert review on aromatic amines

Naoki KOYAMA1, Masayuki MISHIMA2, Kiyohiro HASHIMOTO3, Mika YAMAMOTO4,
Seiichiro KURASHIGE5, Chiaki TAKESHITA6, Masahiro OGAWA7, Hisayoshi OMORI8,
Katsuya YAMADA9, Satsuki CHIKURA10, Shigeharu MUTO2, Soichiro HAGIO11, Fumiya ISHIZUKA12,
Hirofumi OUCHI13, Minami HOKI14, Yusuke NAGATO15

ポスター

e

1

Eisai, 2Chugai Pharmaceutical, 3Takeda Pharmaceutical Company, 4Astellas Pharma, 5EA Pharma,
Ono Pharmaceutical, 7KUMIAI CHEMICAL, 8Taiho Pharmaceutical , 9Mitsubishi Tanabe Pharma, 10Teijin Pharma,
11
Nissan Chemical, 12Nippon Shinyaku, 13Japan Tobacco, 14Nihon Nohyaku, 15FUJIFILM Toyama Chemical
6

研究会 定例会

P-48

xenoBiotic: Ames mutagenicity predictor (2022)

Toshihiko SAWADA1, 2, Tomohiro HASHIMOTO2, Hiroaki WASADA2, Ayato SATO3
1

xenoBiotic Inc., 2Faculty of Regional Studies, Gifu University, Tokai National Higher Education and Research System,
Institute of Transformative Bio-Molecules, Nagoya University, Tokai National Higher Education and Research System

3

Molecular biology of mutagens
ワークショップ

P-49

Effects of NEIL1 and NTH1 knockdowns on the action-at-a-distance mutations induced by
8-oxo-7,8-dihydroguanine (8-hydroxyguanine)
Yoshihiro FUJIKAWA, Tetsuya SUZUKI, Hidehiko KAWAI, Hiroyuki KAMIYA

Department of Nucleic Acids Biochemistry, Graduate School of Biomedical and Health Science, Hiroshima University

P-50

Analysis of the cytotoxic mechanisms of sulforaphane

人名索引

Sakine KOBAYASHI1, Yuduki SOMEYA2, Seiya NISHIBA2, Kazuya TORIUMI2, Shigeki TAKEDA1, 2,
Aya KUROSAWA1, 2, 3
1Sch. Sci. Tech., Gunma Univ., 2Grad. Sch. Sci. Tech., Gunma Univ,
Gunma Univ. Cent. Food Sci. Wellness, Gunma Univ.

3

42

P-51

Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University

P-52

The role of DNA polymerase ζ in the replication of non-B DNA

プログラム

Biochemical and genetic evidence for magnesium requirement of tyrosyl-DNA
phosphodiesterase 2 in the repair of topoisomerase 1 cleavage complexes
Masataka TSUDA, Naoto SHIMIZU, Hiroshi IDE

Yuka HOSODA1, Tetsuya SUZUKI1, 2, Hiroyuki KAMIYA1, 2
1

School of Pharmaceutical Sciences, Hiroshima University,
Graduate School of Biomedical and Health Sciences, Hiroshima University

2

Suppression Mechanism of Deaminated nucleotide-derived genome instability in athermophilic bacterium Thermus thermophilus
Chie MITSUI, Natsumi NAKASHIMA , Miki NISHIMURA, Tatsuo NUNOSHIBAInternational Christian University

P-54

Program

P-53

Cigarette sidestream smoke-induced cellular senescence and associated role of histone H2AX

Yukako KOMAKI, Yuko IBUKI
P-55

Understanding the Molecular Mechanism of Innate Immune Response Caused by DNA Repair
Deficiency
Ken TAKAFUJI1, Koh IWASAKI1, Yuiko MAYUZUMI1, Asuka TACHIKAWA1, Kazuma NAKATANI2,
Manabu YASUI3, Masamitsu HONMA3, Kei-ichi SUGIYAMA3, Ryoji FUJIKI4, Atsushi KANEDA4,
Kaoru SUGASAWA5, Kiyoe URA1, Akira SASSA1

Graduate School of Science, Chiba University,
Graduate School of Medical and Pharmaceutical Sciences, Chiba University,
3
Division of Genetics and Mutagenesis, National Institute of Health Sciences,4
Graduate School of Medicine, Chiba University, 5Biosignal Research Center, Kobe University
2

P-56

1

2

Chugai Pharmaceutical Co., Ltd., Chugai Research Institute for Medical Science, Inc.,
Div. Genetics & Mutag., NIHS, 4Div. Risk Assess., NIHS, 5Biol. Safety Res. Center, NIHS, 6Div. Gen. Affairs, NIHS

3

P-57

e

ポスター

An immunohistochemical analysis with γH2AX on inactivated DNA polymerase kappa knockin mice treated with mitomycin C
Akira TAKEIRI1, Naoko A WADA1, Shigeki MOTOYAMA1, Misaki TANAKA1, Kenji TANAKA1,
Kaori MATSUZAKI1, Saori MATSUO1, Etsuko FUJII1, Masayuki MISHIMA1, Kou-ichi JISHAGE2,
Petr GRÚZ3, Ken-ichi MASUMURA4, Takehiko NOHMI5, Kei-ichi SUGIYAMA3,
Masamitsu HONMA3, 6

シンポジウム1

受賞講演

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

Investigation of a novel system for validation of protein binding

Manami KAWASAKI, Mayu YAMASHITA, Arato TAKEDACHI, Isao KURAOKA
P-58

Novel plasmids for the fluorescence-based evaluation of DNA mismatch repair in human cells
Arato TAKEDACHI1, Tomoki SHIRAKAWA1, Erina MATSUISHI1, Shouji MIZUSAKI1,
Tomoki NAGASAWA1, Ryosuke FUJIKANE2, 3, Masumi HIDAKA2, Shigenori IWAI4, Isao KURAOKA1

研究会 定例会

Department of Chemistry, Faculty of Science, Fukuoka University

1

Department of Chemistry, Faculty of Science, Fukuoka University,
Department of Physiological Science and Molecular Biology, Fukuoka Dental College,
3
Oral Medicine Research Center, Fukuoka Dental College,
4
Graduate School of Engineering Science, Osaka University2

P-59

Comprehensive analysis of DNA adducts formed from candidate chemicals for occupational
bladder cancer
Asuka OBIKANE1, 4, 5, Masami KOMIYA1, Shugo SUZUKI2, Min GI2, 3, Hideki WANIBUCHI2,
Yukari TOTSUKA1, 6
National Cancer Center Research Institute,
Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine,3
Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine,
4
Laboratory of Environmental Hygiene, School of Life and Environmental Science, Azabu University,
5
Department of Biochemistry Graduate School of Medicine University of Yamanashi, 6Nihon University
2

43

人名索引

1

ワークショップ

Carcinogenesis

P-60
プログラム

Whole-genome sequencing revealed the involvement of c-Myc oncogene in the rat liver
tumorigenesis of acetamide
Yuji ISHII1, Kenji NAKAMURA1, Shinji TAKASU1, Norifumi TAKIMOTO1, 2, Tatsuya MITSUMOTO1,
Moeka NAMIKI1, Kumiko OGAWA1
1

Division of Pathology, National Institute of Health Sciences,
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

2

Antimutagenesis and anticarcinogenesis

Program

P-61

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on
Adriamycin-treated cancer cell
Takahiro MATSUMOTO, Erika OHNISHI, Takahiro KITAGAWA, Tetsushi WATANABE
Kyoto Pharmaceutical University, Department of Public Health

P-62

Analysis of antimutagenicity of quinazoline derivertive AK-01 using Bhas 42 cells

Masashi SEKIMOTO1, Yuri HIGUCHI1, Moeka NAMIKI1, Kenji MATSUNO2
1

受賞講演

Department of Environmental Science, School of Life and Environmental Science, Azabu University.,
Department of Pharmacy, Yasuda Women's University

2

New technology

シンポジウム

P-63

Withdrawal

P-64

Designed Synthesis of Translocated Chromosomes by Genome Editing and Induction of
Chromosome Aberrations
Takayoshi SUZUKI1, Kohji YAMAKAGE1, 2, Manabu YASUI2, Akiko UKAI2, Yoshinori TSUKUMO1,
Arihiro KOHARA3, Kei-ichi SUGIYAMA2
1

Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences,
Division of Genetics and Mutagenesis, National Institute of Health Sciences,
3
JCRB Cell Bank, National Institutes of Biomedical Innovation, Health and Nutrition
2

ポスター

e

Regulatory science
P-65

Points to be considered for preparation of SEND data of genotoxicity study

Naoki TORITSUKA1, 2, Konomi IINO1, 3, Norio IMAI1, 4, Yoshifumi KANEKO1, 5,
Terukazu KITAHARA1, 6, Gen SATO1, 7, Hiroyuki NITTA1, 8
1

CDISC Japan User Group (CJUG) SEND Team, 2Bristol-Myers Squibb K.K., 3Ina Research Inc.,
DIMS institute of Medical Science Inc., 5KYORIN Pharmaceutical Co., Ltd., 6Instem Japan K.K., 7Eisai Co., Ltd.,
8
Ono Pharmaceutical Co., Ltd.
4

研究会 定例会

OthersP-66

Analysis of photooxidation using a new bisflavin derivative

Taishu KAWADA1, Koki AKIYAMA1, Takanobu KOBAYASHI1, Katsuhito KINO2
1

ワークショップ

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University,
Department of Nano Material and Bio Engineering, Faculty of Science and Engineering, Tokushima Bunri University

2

人名索引

44