ONCOLOGY

Variant List – UltraSEEK™ Lung Panel
Gene

BRAF

EGFR

CDS

Amino Acid Change

COSMIC ID

c.1406G>T

p.G469V459

c.1406G>C

p.G469A

460

c.1781A>G

p.D594G

467

c.1799T>A

p.V600E476

c.2240_2251del(12)TAAGAGAAGCAA

p.L747_T751>S

6210

c.2582T>A

p.L861Q

6213

c.2239_2247del(9)TTAAGAGAA

p.L747_E749del

6218

c.2238_2255del(18)ATTAAGAGAAGCAACATC

p.E746_S752>D

6220

c.2235_2249del(15)GGAATTAAGAGAAGC

p.E746_A750del6223

c.2573T>G

p.L858R

6224

c.2236_2250del(15)GAATTAAGAGAAGCA

p.E746_A750del6225

c.2156G>C

p.G719A

6239

c.2369C>T

p.T790M

6240

c.2303G>T

p.S768I

6241

c.2155G>A

p.G719S

6252

c.2155G>T

p.G719C

6253

c.2239_2256del(18)TTAAGAGAAGCAACATCT

p.L747_S752del

6255

c.2237_2254del(18)AATTAAGAGAAGCAACAT

p.E746_S752>A

12367

c.2240_2254del(15)TAAGAGAAGCAACAT

p.L747_T751del

12369

c.2240_2257del(18)TAAGAGAAGCAACATCTC

p.L747_P753>S

12370

c.2126A>T

p.E709V

12371

c.2582T>G

p.L861R

12374

c.2307_2308ins(9)GCCAGCGTG

p.V769_D770insASV

12376

c.2319_2320InsCAC

p. H773-V774insH

12377

c.2310_2311insGGT

p. D770-N771insG

12378

c.2319_2320ins(9)AACCCCCAC

p.H773_V774insNPH

12381

c.2239_2248TTAAGAGAAG>C

p.L747_A750>P

12382

c.2239_2251TTAAGAGAAGCAA>C

p.L747_T751>P

12383

c.2237_2255>T

p.E746_S752>V

12384

c.2237_2252>T

p.E746_T751>V

12386

c.2239_2258>CA

p.L747_P753>Q

12387

c.2239_2256>CAA

p.L747_S752>Q

12403

c.2237_2253>TTGCT

p.E746_T751>VA

1241612422

c.2238_2248>GC

p.L747_A750>P

c.2308_2309ins(9)CCAGCGTGG

p.V769_D770insASV

12426

c.2237_2251del(15)AATTAAGAGAAGCAA

p.E746_T751>A

12678

c.2236_2253del(18)GAATTAAGAGAAGCAACA

p.E746_T751del

12728

c.2125G>A

p.E709K

12988

c.2126A>G

p.E709G

13009

For Research Use Only. Not for use in diagnostic procedures.

Variant List – UltraSEEK Lung Panel (PAGE 2 OF 2)
Gene

EGFR

ERBB2

KRAS

PIK3CA

CDS

Amino Acid Change

COSMIC ID

c.2126A>C

p.E709A

13427

c.2311_2312ins(9)GCGTGGACA

p.D770_N771insSVD

13428

c.2235_2248>AATTC

p.E746_A750>IP

13550

c.2235_2251>AATTC

p.E746_T751>IP

13552

c.2309_2310AC>CCAGCGTGGAT

p.V769_D770insASV

13558

c.2237_2257>TCT

p.E746_P753>VS

18427

c.2311_2312ins(3)CAC

p.N771>TH22946

c.2235_2246del(12)GGAATTAAGAGA

p.E746_E749delELRE

28517

c.2237_2253>TTCCT

p.E746_T751>VP

52935

c.2390G>C

p.C797S

5945664c.2389T>A

p.C797S

6493937c.2326_2327ins(3)TTT

p.G776>VC

12552

c.2326_2327ins(3)TGT

p.G776>VC12553

c.2325_2326ins(12)TACGTGATGGCT

p.A775_G776insYVMA

12558

c.2324_2325ins(12)ATACGTGATGGC

p.A775_G776insYVMA

20959

c.34G>T

p.G12C

516

c.34G>A

p.G12S

517

c.34G>C

p.G12R

518

c.35G>T

p.G12V520

c.35G>A

p.G12D

521

c.35G>C

p.G12A522

c.34_35GG>TA

p.G12Y

25081

c.37G>T

p.G13C

527

c.38G>A

p.G13D

532

c.181C>A

p.Q61K

549

c.181C>G

p.Q61E550

c.182A>C

p.Q61P

551

c.182A>G

p.Q61R552

c.182A>T

p.Q61L553

c.183A>Cp.Q61H

554

c.183A>T

p.Q61H555

c.1624G>A

p.E542K

760

c.1633G>A

p.E545K

763

c.3140A>G

p.H1047R

775

c.3140A>T

p.H1047L

776

For Research Use Only. Not for use in diagnostic procedures.
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