ONCOLOGY

Variant List – UltraSEEK™ Colon Panel
GeneBRAF

EGFR

KRAS

Nucleotide Change

Amino Acid Change

COSMIC ID

c.1406G>C

p.G469A

460

c.1406G>A

p.G469E

461

c.1781A>T

p.D594V

466

c.1781A>G

p.D594G

467

c.1799T>A

p.V600E476

c.1476C>A/G

p.S492R

236670c.1474A>C

p.S492R

236671c.1351C>A/c.1351C>G

p.R451S

NA

c.1351C>T

p.R451CNA

c.1391C>Tp.S464LNA

c.1393G>A

p.G465R

6110417c.1393G>A/C

p.G465RNA

c.1394G>A

p.G465ENA

c.1400A>C

p.K467TNA

c.1473A>G

p.I491M

NA

c.34_35GG>TT

p.G12F

512

c.34_35GG>CT

p.G12L514

c.35_36GT>TC

p.G12V515

c.34G>T

p.G12C

516

c.34G>A

p.G12S

517

c.34G>C

p.G12R

518

c.35G>T

p.G12V520

c.35G>A

p.G12D

521

c.35G>C

p.G12A522

c.37_39GGC>CGT

p.G13R

526

c.37G>T

p.G13C

527

c.37G>A

p.G13S

528

c.37G>C

p.G13R

529

c.38G>A

p.G13D

532

c.38G>C

p.G13A

533

c.38G>T

p.G13V534

c.175G>A

p.A59T546

c.176C>A

p.A59E547

c.181C>A

p.Q61K

549

c.181C>G

p.Q61E550

c.182A>C

p.Q61P

551

c.182A>G

p.Q61R552

c.182A>T

p.Q61L553

c.183A>C

p.Q61H554

For Research Use Only. Not for use in diagnostic procedures.

Variant List – UltraSEEK Colon Panel (PAGE 2 OF 3)
GeneKRAS

NRAS

Nucleotide Change

Amino Acid Change

COSMIC ID

c.183A>T

p.Q61H555

c.38_39GC>TT

p.G13V12721

c.436G>A

p.A146T

19404

c.437C>T

p.A146V

19900

c.436G>C

p.A146P

19905

c.351A>C

p.K117N

19940

c.34_35GG>TA

p.G12Y

25081c.176C>G

p.A59G

28518

c.351A>T

p.K117N

28519

c.35_36GT>AG

p.G12E

30566

c.34_36GGT>TGG

p.G12W

36281

c.180_181TC>AA

p.Q61K

87298

c.34_36GGT>AGA

p.G12R

249888c.175G>T

p.A59S

1235389c.176_178delCAG

p.A59del1667040c.37_38GG>TT

p.G13F

1685355c.350A>G

p.K117R

4696722c.35_36GT>CA

p.G12A

5413585c.175G>C

p.A59PNA

c.349A>G

p.K117E

NA

c.350A>C

p.K117TNA

c.437C>G

p.A146G

NA

c.34_35GG>CC

p.G12P559

c.34_35GG>TA

p.G12Y560

c.34G>C

p.G12R

561

c.34G>T

p.G12C

562

c.34G>A

p.G12S

563

c.35G>A

p.G12D

564

c.35G>C

p.G12A

565

c.35G>T

p.G12V566

c.37_38GG>TA

p.G13Y

568

c.37G>C

p.G13R

569

c.37G>T

p.G13C

570

c.37G>A

p.G13S571

c.38_39GT>TC

p.G13V572

c.38G>A

p.G13D

573
574

c.38G>T

p.G13V

c.38G>C

p.G13A575

c.175G>A

p.A59T578

c.181C>A

p.Q61K

580
2For Research Use Only. Not for use in diagnostic procedures.

Variant List – UltraSEEK Colon Panel (PAGE 3 OF 3)
GeneNRASPIK3CA

Nucleotide Change

Amino Acid Change

COSMIC ID

c.181C>G

p.Q61E581

c.182A>C

p.Q61P

582

c.182A>T

p.Q61L583

c.182A>G

p.Q61R584

c.183A>T

p.Q61H585

c.183A>C

p.Q61H586

c.34_35GG>AA

p.G12N

12723

c.37_38GG>AA

p.G13N

24668

c.436G>A

p.A146T

27174

c.182_183AA>TG

p.Q61L

30646

c.182_183AA>GG

p.Q61R

33693

c.181_183CAA>AAG

p.Q61K

53223

c.437C>T

p.A146V

4170228c.436G>C

p.A146P

4172577

c.349A>Gp.K117E

NAc.350A>C

p.K117T

NAc.350A>G

p.K117R

NAc.351G>C

p.K117N

NA

c.351G>T

p.K117N

NA

c.436G>T

p.A146S

NA

c.437C>G

p.A146G

NA

c.1624G>A

p.E542K

760

c.1633G>A

p.E545K

763

c.3140A>G

p.H1047R

775

c.3140A>T

p.H1047L

776

For Research Use Only. Not for use in diagnostic procedures.
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