SYSTEMSMassARRAYSystem®

Uncompromised
Molecular Testing

For Research Use Only.
Not for use in diagnostic procedures.

The MassARRAY System
Challenges in Molecular Testing
Are you tired of managing trade-offs between sample quality, limited budget, throughput constraints, andbioinformatics struggles? Selecting a molecular testing platform doesn’t have to mean compromise.

THE AGENA SOLUTION
The MassARRAY System is a benchtop mass spectrometer that provides timely and accurate multiplexedanalysis of up to hundreds of clinically relevant mutations in a single workflow.
The flexible throughput capacity can meet the needs of any testing volume. The system works withstandard 96 and 384 well plates.
The system supports diverse applications, allowing labs toconsolidate tests onto a single platform.
The technology is well proven for the accurate
and reproducible results illustrated in over 4,000
publications.

For Research Use Only. Not for use in diagnostic procedures.

Single Day TurnaroundDNA to data in a single workday. Load and go processing allows
for automated sample handling and data analysis remotely.
Unlike NGS, there is no need to run data through cumbersomeand expensive data pipelines. The MassARRAY Analyzer provides
easy to read and interpret data.

Low Cost Per Sample
Multiplexed analysis reduces per sample cost, targeted
content eliminates bioinformatics burden, and scalable
throughput optimizes batch and resource requirements.

Flexible Throughput
Direct detection of short amplicons enables compatibility
with even poor or degraded nucleic acid sample types.
The throughput capacity of the system allows a lab torun in 96 and/or 384-well format.

Diverse Applications
One system, many applications. The MassARRAYsystem supports a broad range of applications
including hereditary genetic testing, solid and liquidtumor profiling, and pharmacogenetic testing.

MassARRAY System Workflow
The MassARRAY System workflow is highly reproducible and generates results within an 8-hour day.
The system offers an automated workflow for both 96 and 384-well applications depending on thethroughput needs of the laboratory.

AUTOMATED WORKFLOW
The MassARRAY Analyzer with Chip Prep Module 96 reduces hands on time with load-and-go processing.
It can accommodate both 96-well microtiter plates and SpectroCHIP® CPM Arrays.

PCR
AMPLIFICATION

SAP &PRIMER

EXTENSIONSAMPLE TRANSFER
AND DATA ACQUISITIONDATA ANALYSISAND REPORTING

28 MINS HANDS-ON TIME
135 MINS
15 MINSHands-On
Time

25 MINS
3 MINS
Hands-OnTime

260 MINS

90 MINS

8.8 HRS ELAPSED TIME

5 MINS
Hands-OnTime

5 MINS
Hands-On
Time

HIGH-THROUGHPUT AUTOMATED WORKFLOW
The MassARRAY Analyzer with Chip Prep Module 384 provides automated workflow for labs who require
higher throughput with 384 well microtiter plates and SpectroCHIP® CPM Arrays. For iPLEX® Pro andMassCLEAVE ™ Chemistries.

PCR
AMPLIFICATION

SAP &PRIMER

EXTENSIONSAMPLE TRANSFER
AND DATA ACQUISITIONDATA ANALYSISAND REPORTING

28 MINS HANDS-ON TIME
135 MINS
15 MINS
Hands-OnTime

25 MINS
3 MINS
Hands-OnTime

260 MINS
5 MINS
Hands-OnTime

160 MINS
5 MINS
Hands-OnTime

10 HRS ELAPSED TIMESYSTEMSMALDI-TOF Mass Spectrometry
The MassARRAY System is a Matrix-Assisted Laser Desorption Ionization – Time ofFlight (MALDI-TOF) mass spectrometer customized for the precise detection of DNAmolecules. The molecules are distinguished by their time-of-flight after being ionized ina vacuum chamber. Direct analysis of the mass of the molecules eliminates the need for
fluorescence or other labeling.

SPECTROCHIP ARRAY: The SpectroCHIP
Array comes in a CPM 96 or CPM 384 padformat, upon which the sample is dispensed.
The DNA extension products or analytes
co-crystallize with the matrix.

DNA IONIZATION: The analyte
crystals are irradiated by a laser,inducing desorption and ionizationof the molecules

DNA SEPARATION: The positively charged DNA molecules accelerate up thevacuum tube towards a highly sensitive detector. The speed of the molecules
is inversely proportional to the mass of the individual extension products andseparation occurs by time-of-flight. The software processes the time-of-flightand differentiates the variants by their mass, producing a mass spectrum.

16WildType

Intensity

1412
1081%
VARIANT64205580 5600

5620 5640 5660 5680 5700

Mass5720 5740 5760

Lightest ionsarrive firstHeaviest ionsarrive at thedetector last

Analyte isionized

ANALYSIS: The integrated software provides auser-friendly interface to generate reports which
identify the targets and review spectra. Data issaved to the database and can be retrieved at
any time for analysis.

Ions areDetected

System Options

SPECIFICATIONSMassARRAY System with CPM 96

MassARRAY System with CPM 384

Components:

Components:

MassARRAY Analyzer 4

Dimensions:

Chip Prep Module 384

Integrated computer

Integrated Computer

37W x 43H x 27D in

Dimensions:(104W x 110H x 68D cm)
Capacity:

2 x Microtiter plates (96-well)

90 minutes per 96-well plate

37W x 43H x 27D in(104W x 110H x 68D cm)

Capacity:

2 x SpectroCHIP CPM 96 Arrays
Processing time:

MassARRAY Analyzer 4

Chip Prep Module 96

2 x Microtiter plates (384-well)
2 x SpectroCHIP CPM 384 Arrays

Processing time:

160 minutes per 384-well plate

ORDERING INFORMATION
Catalog No.

Product10411

MassARRAY System, 384/96 Genotyping

10412

MassARRAY System, 384/96 EpiTyper

10445

MassARRAY System with Chip Prep Module, 96 Genotyping

10446

MassARRAY System with Chip Prep Module, 96 EpiTyper

10447

MassARRAY System with Chip Prep Module, 384 Genotyping

10448

MassARRAY System with Chip Prep Module, 384 EpiTyper

For Research Use Only. Not for use in diagnostic procedures.

Agena Bioscience, Inc.
4755 Eastgate Mall
San Diego, CA 92121
Phone: +1.858.882.2800

SYS0003 02

Order Desk: +1.858.202.9301
Order Desk Fax: +1.858.202.9220
orderdesk@agenabio.com
Web: agenabio.com

USEUAP
CN+1.877.4.GENOME+49.40.899676.0+61.7.3088.1600+86.21.6427.0566

MassARRAY, iPLEX and Agena Bioscience are registered trademarks of Agena Bioscience, Inc. UltraSEEKand MassCLEAVE are trademarks of Agena Bioscience, Inc. ©2018 Agena Bioscience, Inc. All rights reserved.