TOXCENTER (Toxicology Center Database)
Subject
Coverage

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File Type

Bibliographic

Features

Thesauri

Biosystematic Code (/BC), MeSH Tree Number (/MN), Chemical Name (/CN),
Organism (/ORGN), Controlled Term (/CT), Supplementary Term (/ST),
Geographic Term (/GT)

Alerts (SDIs)

Weekly or monthly (Weekly is the default)

CAS Registry
Number® IdentifiersPage Images

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Adverse Drug Reactions
Air Pollution
Animal Venom
Antidotes
Carcinogenesis via Chemicals
Chemically Induced Diseases
Drug Evaluations
Environmental Pollution

Learning Database

Structures

RecordContent••••

File SizeMore than 16.2 million records (01/2022)

Coverage

1907-present

Updates

WeeklyLanguage

English

Database
Producer

Chemical Abstracts Service
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P.O. Box 3012
Columbus, Ohio 43210-0012 USA
Phone: 800-753-4227 (North America)
Phone: 614-447-3700 (worldwide)Fax:
614-447-3751
Email: help@cas.org

Food Contamination
Mutagenesis
Occupational Hazards
Pesticides and Herbicides
Radiation Teratology
Toxicological Analysis
Waste Disposal

Bibliographic data
Abstracts
Indexing terms
CAS Registry Numbers

January 2022

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TOXCENTER

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User Aids• Online Helps (HELP DIRECTORY lists all help messages available)• STNGUIDE

Clusters

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January 2022

ANEUPLBIOSIS
CAplusSM
CIS
CLINICALTRIALS.GOV
CRISP
DART
EMIC
EPIDEMETIC
FEDRIP
HAPAB
HMTC
IPA
ISRCTNMEDLINE®
PESTABPPBIBRISKLINE
TSCATSALLBIBAUTHORS
BIOSCIENCECASRNSCOMPANIESCORPSOURCEENVIRONMENT

Aneuploidy File
1946 to the present
1907 to the present
CIS Abstracts
ClinicalTrials.gov
Toxicology Research Projects
Development and Reproductive Toxicology File
Environmental Mutagen Information Center File
Epidemiology Information System
Environmental Teratology Information Center File
Federal Research in Progress
Health Aspects of Pesticides Abstract Bulletin
Hazardous Materials Technical Center File1970 to the present
ISRCTN Register of Clinical Trial Numbers
1946 to the present
Pesticides Abstracts
Poisonous Plants Bibliography
Swedish National Chemicals Inspectorate
Toxic Substances Control Act Test Submissions• FOOD• FORMULATIONS• HEALTH• MEDICINE• PHARMACOLOGY• TOXICOLOGYSTN Database Clusters information (PDF)3
TOXCENTER

Search and Display Field Codes
The fields that allow left truncation are marked with an asterisk (*).
Search Field Name

SearchCode

Display
Codes

Search Examples

Basic Index * (contains single words
from the title (TI), abstract (AB),
named person (NA), chemical name(CN), supplementary term (ST),controlled term (CT), geographic
term (GT), organism (ORGN),
biosystematic codes (BC), and genename (GEN) fields, as well as CAS
Registry Numbers (RN))

None (or/BI)

S GROWTH FACTORS HEPATITISS ?ALLEL?
S 79-07-2
S MEDICAL DEVICE# (L) MANUFACTURER#
S HOME (S) INTERVENTION

AB, BC, CN, CT,
GEN, GT, NA,
ORGN, RN, ST,
TI

Abstract * (1)

/AB

AB

Accession Number
Author (includes inventor and editor)(2)
Author Group
Author Identifier
Biosystematic Code (3,4,5) Superterm
(6)

/AN
/AU

S ANTIPSYCHOT?/AB
S INDUCED-ARRHYTHMIA/AB
S ?TOXIC?/AB
S (HAND (S) TREMOR#)/AB
S 2001:3269/AN
S SCOTT, M?/AU

AUTH
AUID
BC

Chemical Name (5,7) (contains names
from the chemical name (CN) andCAS Registry Number (RN) fields)
Chemical Name Segment *Classification Code (8) (Concept Code)/CNS BROOKS A?/AUTH
S 0000-0002-6514-2355/AUID
S PURPLE BACTERIA/BC
S 85306/BC
S HOMINIDAE/BC AND 57-88-5
S INTERLEUKIN?/CNS SAL-I/CN

CN, RNCC

Clinical Trial Numbers/NCT

Collaborator
Comment
Controlled Term (5,10,11) (includes
main terms)

/AUCL
/CM
/CT

Corporate Source (9,12) (Patent
Assignee)/CS

Country of Publication (13) (code andtext)
Digital Object Identifier (32)/CY

S ?FLUOR?/CNS
S GENERAL BIOLOGY?/CCS "FORESTRY AND FOREST PRODUCTS"/CC
S 28:08.04/CC
S 60-2/CC
S 10006/CC
S ISRCTN02140505/NCT
S NCT00005487/NCT
S BEGAY JACK/AUCLS TOXICOL?/CMS SUNSCREENING AGENTS/CT
S (HYPERTENSION (L) BL)/CT
S *MEDICARE/CT
S F3.375.100./CT
S FORD/CSS SURGERY DEPARTMENT/CSS ROSIGLITAZONE STUDY GROUP/CS
S L1 AND US/CY/DOI (or/FTDOI)/DT (or/TC)/DB

S 10.3109/?/DOI

FTDOI, DOI

S L1 AND J/DTDT

S DB>=2000

DB

/DE

S DE>=2000

DE

/EPD
/EPY
/EML
/ED
/FA

S 21 DEC 2012
S 2013/EPY
S A.DAY@UTORONTO.CA/EML
S L8 AND ED>=20020600
S L7 AND RN/FA

EPD, SO
EPY, SO
CS, EML
ED, UP
Not displayed

Document Type (code and text) (14)Duration Begin, Date (Initial ProjectDate) (15,16)
Duration End, Date (Final Project Date)(15,16)
Electronic Publication Date (15,22)
Electronic Publication Year (15,22)
Email Address (17)Entry Date (15)Field Availability (code and text)

/AUTH
/AUID
/BC

/CNS
/CC

AN
AU, SO

CN, RN

NCT
AUCL
CM
CT

CS

CY

January 2022

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TOXCENTER

Search and Display Field Codes (cont’d)Search Field Name

SearchCode

File Segment/FS

Gene Name (13)/GEN

Grant Number (22)Grant Organization (22)Group Author
Geographic Term (3,5)

/GN
/GO
/AUGR
/GT

Index Term (contains single words
from the named person (NA),chemical name (CN), supplementaryterm (ST), controlled term (CT),geographic term (GT), organism(ORGN), and biosystematic codes(BC) fields, as well as CAS Registry
Numbers (RN))
International Standard (Document)
Number (contains CODEN, ISBN,and ISSN) (17)Inventor (18)
Journal Title Code (10)/IT

Journal Title, Full and Abbreviated (19)Language (code and text) (20)
Meeting Date (3,15,21)
Meeting Location (3)Meeting Organizer (3,9)
Meeting Title (3)Meeting Year (3,14)
Named Person or Institution (22)
Number of Contract (33)

/JT
/LA
/MD
/ML
/MO
/MT
/MY
/NA
/NC

Number of Report (22)/NR

Order Number (23)Organism Name (3,5) (includes
Superterms) (6)Other Source (24)Patent Country (18)

/ON
/ORGN

Patent Number (18,31)
Patent Number/Kind CodePublication Date (15,19)
Publication Year (15,19)
Section (25) (code and text)
Source (contains publication title,
publication date, collation information(volume, issue, pagination), meeting
information, patent information,
editor, publisher, number of report,
space flight mission, investigator,
and affiliation, CODEN, ISSN, andISBN)
Summary Language (26) (code andtext)

January 2022

/ISN

/IN
/JTC

/OS
/PC
(or /PCS)/PN(or /PATS)
/PNK
/PD
/PY
/SC
/SO

/SL

Display
Codes

Search Examples
S CAPLUS/FS AND MODULATIONS CLINICAL TRIALS.GOV/FSS C-JUN/GENS HUMAN APOE GENE/GEN
S P30 CA016672/GN
S NCI/GOS DANACOL GROUP/AUGR
S (PALEARCTIC REGION (S) AFRICA)/GTS UK/GTS GENETIC ENGINEERING/IT
S (BACTERIA (L) VIRUS)/ITS (CYTOTOXIN (S) PROTEIN)/IT
S 64-17-5/ITFS

S LANCAO/ISN
S 0022-3263/ISN
S 9971-62-253-X/ISNS BUSH R?/IN
S 9892302/JTC
S AN7/JTCS DRUG SAF./JT
S L8 AND EN/LA
S MD>20010600
S ORLANDO/ML
S ONCOLOGISTS/MO
S (ANNUAL AND SCIENTI?)/MT
S MY>=2001
S MOZART?/NA
S DE07085/NC
S NCI/NC
S NASA-00001502/NR
S NASA/NRS NTIS-OTS0590168/ON
S RODENTIA/ORGN AND L1
S HUMANS+ALL/ORGN AND L1
S (2001:9177 AND IPA)/OSS US/PC

ISN, SO

S US4561876/PN

PI

S US2005233010/PNK
S PD>=20020100
S 2001-2002/PY
S DRUG ANALYSIS/SC
S 8/SCS EPA/OTS/SOS (NEW DRUGS AND 19 AND 1)/SO
S (UK AND PAT)/SO
S FLIGHT EXPERIMENT/SOS SCIENCE PUBLISHER/SOS (JPCHAX AND ASAP)/SOS NASA00027887/SO

PNK
PD, PI, SO
PI, PY, SOSC

S DE/SL

SL

GEN
GN
GO
AUGR
GT
BC, CN, CT, GT,
NA, ORGN, RN,
ST

AU
SO
JT, SOLA
MD, SO
ML, SO
MO, SO
MT, SO
MD, MY, SO
NA
NC
NR, SOON
ORGN
OS
PC, PI

SO

5
TOXCENTER

Search and Display Field Codes (cont’d)Search Field Name

SearchCodeSupplementary Term (5,27,28)/ST

Update Date (15)Unique Ingredient Identifier (22)
Uniform Resource Locator (3)Zip Code (30)

/UP
/UNII
/URL
/ZP

Display
Codes

Search Examples
S ANTIDOTES/STS CARDIAC DRUGS/ST
S CHEMISTRY/ST (L) MAJOR CONCEPTS/FA
S L1 AND UP>=20020600
S 9RMU91N5K2/UNIIS HTTP://WWW.BIOSCIENCE?/URL
S 02139/ZP

ST

ED, UPUNII
SO, URL
CS, ZP

(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)

Available for all file segments except ANEUPL and ETIC.
Available for all file segments except TSCATS.
Available for BIOSIS file segment only.
The /BC field is a subset of the /ORGN field.
There is an online thesaurus associated with this field.
Enter HELP STERMS at an arrow prompt in the file for a list of superterms.
Available for BIOSIS, CAPLUS, DART, EMIC, ETIC, IPA and MEDLINE file segments.
Contains code, text, and major terms for BIOSIS file segment; contains CA section and subsection for CAPLUS file segment;
contains code and text for IPA file segment; contains the code for the CIS file segment; contains the TSCA Section for the TSCATS
file segment.
(9) Search with implied (S) proximity is available in this field.
(10) Available for DART, EMIC and MEDLINE file segments only.
(11) MeSH Tree Numbers are also searched in this field. (L) proximity is available with Qualifiers. Postings for MeSH headings do notinclude narrower terms, while MeSH Tree Numbers do include all narrower levels.
(12) Available for BIOSIS, CAPLUS, CIS, CRISP, DART, EMIC, FEDRIP, IPA, MEDLINE, PESTAB AND TSCATS file segments.
(13) Available for CAPLUS and MEDLINE file segments only.
(14) Available for ANEUPL, BIOSIS, CAPLUS, CIS, DART, EMIC, ETIC, IPA, MEDLINE and PESTAB file segments.
(15) Numeric search field that may be searched using numeric operators or ranges.
(16) Available for FEDRIP file segment only.
(17) Available for BIOSIS, DART, EMIC, and MEDLINE file segment only.
(18) Available for BIOSIS and CAPLUS file segments only.
(19) Available for all file segments except CRISP, FEDRIP and TSCATS.
(20) Available for all file segments except EPIDEM, PPBIB and TSCATS.
(21) When the meeting date is multiple days, e.g., 5-10 FEB 2001, only the first and last days are searchable.
(22) Available for MEDLINE file segment only.
(23) Available for TSCATS file segment only.
(24) Available for BIOSIS, CAPLUS, EMIC, FEDRIP, IPA and MEDLINE file segments only.
(25) Available for IPA file segment only.
(26) Available for IPA file segment only.
(27) Available for ANEUPL, BIOSIS, CIS, CRISP, EMIC, EPIDEM, ETIC, FEDRIP, HMTC, IPA, MEDLINE, PPBIB, RISKLINE and
TSCATS file segments.
(28) Search single words from the CAPLUS ST field in /BI or /IT.
(29) Available for CRISP, EPIDEM, FEDRIP file segments only(30) Available for CRISP and FEDRIP file segments only.
(31) Either STN or Derwent format may be used.
(32) Available in BIOSIS and MEDLINE file segments only. Unable to EXPAND on this field.
(33) Available for DART, and EMIC file segments only.

Limiting Search Codes
Only an L-number for an answer set created in TOXCENTER may be limited.
Search Field Name
Animal subject
English language records
Female subject
Human subject
Male subject

SearchCode/ANIMAL/ENGLISH/FEMALE/HUMAN/MALE

Search Examples
S L3/ANI (1)S L1/ENG,HUM (1,2)
S L2/FEM (1)S L1/HUM (1)S L2/MALE (1)(1) The code may be abbreviated to the first three letters.
(2) An answer set may be limited to more than one subject area.

January 2022

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TOXCENTER

Chemical Name (/CN) Thesaurus
All Relationship Codes can be used with both the SEARCH and EXPAND command in the Chemical Name(/CN) thesaurus.
Code
ALL

AUTO (1)
HM
NOTE
PFT
RN

RR

XUSE

Content
All associated terms(SELF, CN, RN, RR, EC, UF, USE, HM, PA, INDX, NOTE,
PNTE, RE)
Automatic Relationship Code (SELF, USE)
Heading Mapped to (SELF, RN, RR, CN, EC, HM)
Notes associated with the term
(SELF, CN, RN, EC, RR, INDX, PA, NOTE, PNTE, RE)
Preferred and Forbidden Terms(SELF, CN, RN, EC, RR, UF, USE)
CAS Registry Number associated with the name or nameassociated with CAS Registry Number(SELF, CN, RN, EC)
Associated CAS Registry Numbers(SELF CN, RN, EC, RR)
USE and UF terms from the current MeSH
(SELF, USE, UF)

ExampleE CHAETOGLOBOSINS+ALL/CN
E 8057-37-2+ALL/CN
E BROMOACETIC ACID+AUTO/CNE NEOSPORIN+HM/CN
E SERICYSTATIN+NOTE/CNE EC 2.4.1.119+NOTE/CNE COMBRETASTATIN+PFT/CNS MANGANESE CHLORIDE+RN/CN
E 20603-88-7+RN/CN
E FLUVALINATE+RR/CN
E 7773-01-5+RR/CN
E 9RMU91N5K2+RR/CN
E 6-CHRYSENYLAMINE+XUSE/CN
S 6-CHRYSENAMINE+XUSE/CN(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.

Field Descriptors for the /CN Thesaurus
Code

CN
EC
HM
INDX
NOTE
PA
PNTE
RE
RN
RR
UF
USE

January 2022

Description
Self
Chemical Name and Enzyme Name
Enzyme Commission Numbers
Heading Mapped To
Indexer Note
Scope Note
Pharmacological Action
Previous Indexing Note
Reference
CAS Registry Number
Related Registry Numbers
Used For Term
Used Term

7
TOXCENTER

Controlled Term (/CT) Thesaurus
All Relationship Codes can be used with both the SEARCH and EXPAND command in the Controlled Term(/CT) thesaurus.
The /CT thesaurus contains the current Controlled Terms. MeSH Tree Numbers are searchable terms in the/CT thesaurus.
The /CT and /MN Thesaurus have the same EXPAND capabilities except when expanding MeSH Tree
Numbers. The /CT Thesaurus will expand the same Tree Number hierarchy, while the /MN Thesaurus will
expand the MeSH terms corresponding to the various MeSH Tree Numbers.
Code
ALL

AUTO (1)

BT
HIE
KT
MN
NOTE

NT
PFT

QLF

QPFT
RT
STD
UF
USE
XUSE

Content
All associated terms(BT, SELF, MN, DC, NOTE, INDX, ENTC, AQ, PNTE,
HNTE, ONTE, MHTH, BXTH, PA, UF, USE, QUSE, NT,
QLF, QA, QCAT, QNOTE, QINDX, QHNTE, QONTE, QUF,
RT)
Automatic Relationship Code (Preferred Terms andQualifiers)(SELF, USE, QUSE)Broader Terms(BT, SELF, MN)
Hierarchy (Broader and Narrower Terms)(BT, SELF, MN, NT)
Keyword Terms (multiword phrases containing the term)(SELF, KT)
Tree Number and descriptor class(SELF, MN, DC)
Notes associated with the term
(SELF, MN, NOTE, INDX, ENTC, AQ, PNTE, HNTE, ONTE,
MHTH, BXTH, PA)
Narrower Terms(SELF, MN, NT)
All Preferred and Forbidden Terms(SELF, MN, ENTC, AQ, UF, USE)
Qualifier and associated terms(SELF, AQ, QUSE, QLF, QA, QCAT, QNOTE, QINDX,QHNTE, QONTE, QUF)
Qualifier Preferred(SELF, QUSE, QLF, QUF)
Related Terms(SELF, MN, RT)
Standard (Broader, Narrower, and Related Terms)(BT, SELF, MN, NT, RT)
Used For Terms (Forbidden Terms)(SELF, MN, UF)
Used Terms (Preferred Terms)(SELF, MN, USE)
USE and UF terms from the current MeSH
(SELF, USE, UF)

ExampleE PEPTIC ULCER+ALL/CT
E C6.405.748+ALL/CT

E NASAL SINUSES+AUTO/CT
E ADV EFF+AUTO/CT
E PREGNANCY TESTS+BT/CT
E RECEPTORS, DRUG+HIE/CTS SHOCK+KT/CT
E PROSTHESIS FAILURE+MN/CT
E RHINOVIRUS+NOTE/CTS NEURONS+NT/CT
E FIBRIN TISSUEADHESIVE+PFT/CTS ADVERSE EFFECTS+QLF/CT

E PSYCHOLOGY+QPFT/CT
E ETHICS+RT/CT
S SPINAL CORD+STD/CT
E PNEUMONIA+STD/CT
E SEX BEHAVIOR+UF/CT
E JOINT TUBERCULOSIS+USE/CT
E RADICULITIS+XUSE/CT(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.

January 2022

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TOXCENTER

Field Descriptors for the /CT Thesaurus
Code

AQ
BT
BXTH
DC
ENTC
HNTE
INDX
KT
MH
MHTH
MN
NOTE
NT
ONTE
PA
PNTE
QA
QCAT
QHNTE
QINDX
QLF
QNOTE
QONTE
QUF
QUSE
RT
UF
USE

Description
Self
Allowable Qualifier
Broader Term
Backwards Cross Reference Thesaurus
Descriptor Class
Entry Combination
History Note
Indexer Note
Keyword Terms
MeSH Heading
MH Thesaurus
MeSH Tree Number
Scope Note, Consider Also Terms
Narrower Term
Online Note
Pharmacological Action
Previous Indexing Note
Qualifier Abbreviation
Allowable Categories
Qualifier History Note
Qualifier Indexer Note
MeSH Qualifier (subheading)
Qualifier Scope Note
Qualifier Online Note
Qualifier Use For
Qualifier Use
Related Term
Used For Term
Used Term

Geographic Term (/GT) Thesaurus
All Relationship Codes can be used with both the SEARCH and EXPAND command in the Geographic Term(/GT) thesaurus.
Code
ALL
AUTO (1)
BT
KT
NT
PFT
STD
UF
USE

Content
All associated terms(BT, SELF, UF, USE, NT)
Automatic Relationship Code
(SELF, USE)
Broader Terms(BT, SELF)
Keyword Terms (multiword phrases containing the term)(SELF, KT)
Narrower Terms(SELF, NT)
Preferred and Forbidden Terms(SELF, UF, USE)
Standard (Broader and Narrower Terms)(BT, SELF, NT)
Used For Terms (Forbidden Terms)(SELF, UF)
Used Terms (Preferred Terms)(SELF, USE)

ExampleE TANZANIA+ALL/GT
E GOLD COAST+AUTO/GTE POLAND+BT/GTE GERMANY+KT/GT
E AFRICA+NT/GT
E DDR+PFT/GTE PALEARCTIC REGION+STD/GTE IVORY COAST+UF/GT
E ABYSSINIA+USE/GT(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.
January 2022

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TOXCENTER

Field Descriptors for the /GT Thesaurus
Code

BT
KT
NT
UF
USE

Description
Self
Broader Term
Keyword Term
Narrower Term
Used For Term
Used Term

MeSH Tree Number (/MN) Thesaurus
In the MeSH Tree Number (/MN) Thesaurus, all Relationship Codes can only be used with the EXPAND
command.
The /CT and /MN Thesaurus have the same EXPAND abilities except when expanding MeSH Tree Numbers.
The /CT Thesaurus will expand the same Tree Number hierarchy, while the /MN Thesaurus will expand the
MeSH terms corresponding to the various MeSH Tree Numbers.
The /MN thesaurus does not have any postings. When searching, it is necessary to edit the field code to /CT.
Code
ALL

AUTO (1)

BT
HIE
KT
MN
NOTE

NT
PFT
QLF

QPFT
RT
STD
UF
USE
XUSE

Content
All associated terms(BT, SELF, MN, MH, DC, NOTE, INDX, ENTC, AQ, PNTE,
HNTE, ONTE, MHTH, BXTH, PA, UF, USE, QUSE, NT,
QLF, QA, QCAT, QNOTE, QINDX, QHNTE, QONTE, QUF,
RT)
Automatic Relationship Code (Preferred Terms andQualifiers)(SELF, USE, QUSE)Broader Terms(BT, SELF, MN, MH)
Hierarchy (Broader and Narrower Terms)(BT, SELF, MN, MH, NT)
Keyword Terms (multiword phrases containing the term)(SELF, KT)
Tree Number and descriptor class(SELF, MN, MH, DC)
Notes associated with the term
(SELF, MN, MH, NOTE, INDX, ENTC, AQ, PNTE, HNTE,
ONTE, MHTH, BXTH, PA)
Narrower Terms(SELF, MN, MH, NT)
Preferred and Forbidden Terms(SELF, MN, MH, ENTC, AQ, USE, UF)
Qualifier and associated terms(SELF, QUSE, QLF, QA, QCAT, QNOTE, QINDX, AQ,
QHNTE, QONTE, QUF)
Qualifier Preferred(SELF, QUSE, QLF, QUF)
Related Terms(SELF, MN, MH, RT)
Standard (Broader, Narrower, and Related Terms)(BT, SELF, MN, MH, NT, RT)
Used For Terms (Forbidden Terms)(SELF, MN, MH, UF)
Used Terms (Preferred Terms)(SELF, MN, MH, USE)
USE and UF Terms from the current MeSH
(SELF, USE, UF)

ExampleE GRANULOMA+ALL/MN
E C23.550.+ALL/MN

E PANCREATICCHOLERA+AUTO/MN
E ILLUSIONS+BT/MN
E CHLAMYDIA+HIE/MN
E SHOCK+KT/MN
E ABSCESS+MN/MN
E SPINAL NERVES+NOTE/MN

E TOOTH+NT/MN
E PROSTHESIS FAILURE+PFT/MN
E AE+QLF/MN

E METABOLISM+QPFT/MN
E AIR BAGS+RT/MN
E ALCOHOLISM+STD/MN
E C21.613.455.571.+STD/MN
E IODIDE PEROXIDASE+UF/MN
E OPHTHALMIA+USE/MN
E ARSENIC POISONING+XUSE/MN(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.
January 2022

10
TOXCENTER

Field Descriptors for the /MN Thesaurus
Code

AQ
BT
BXTH
DC
ENTC
HNTE
INDX
KT
MH
MHTH
MN
NOTE
NT
ONTE
PA
PNTE
QA
QCAT
QHNTE
QINDX
QLF
QNOTE
QONTE
QUF
QUSE
RT
UF
USE

January 2022

Description
Self
Allowable Qualifier
Broader Term
Backwards Cross Reference Thesaurus
Descriptor Class
Entry Combination
History Note
Indexer Note
Keyword Terms
MeSH Heading
MH Thesaurus
MeSH Tree Number
Scope Note, Consider Also Terms
Narrower Term
Online Note
Pharmacological Action
Previous Indexing Note
Qualifier Abbreviation
Allowable Categories
Qualifier History Note
Qualifier Indexer Note
MeSH Qualifier (subheading)
Qualifier Scope Note
Qualifier Online Note
Qualifier Use For
Qualifier Use
Related Term
Used For Term
Used Term

11
TOXCENTER

Organism (/ORGN) Thesaurus
All Relationship Codes can be used with both the SEARCH and EXPAND command in the Organism(/ORGN, /BC) thesaurus.
Code
ALL
AUTO (1)
BT
HIE
KT
NOTE
NT
PFT
RT
STD
UF
USE

Content
All associated terms(BT, SELF, NOTE, UF, USE, NT, RT, BC)
Automatic Relationship Code
(SELF, USE)
Broader Terms(BT, SELF)
Hierarchy(BT, SELF, NT)
Keyword Terms (multiword phrases containing the term)(SELF, KT)
Notes associated with the term
(SELF, NOTE)
Narrower Terms(SELF, NT)
Preferred and Forbidden Terms(SELF, UF, USE)
Related Terms(SELF, RT)
Standard (Broader, Narrower, and Related Terms)(BT, SELF, NT, RT)
Used For Terms (Forbidden Terms)(SELF, UF)
Used Terms (Preferred Terms)(SELF, USE)

ExampleE RODENTIA+ALL/ORGN
E PISCES+AUTO/ORGN
E BOVIDAE+BT/ORGN
E PISCES+HIE/ORGN
E VIRUSES+KT/ORGN
E PROTOZOA+NOTE/ORGNE AMPHIBIA+NT/ORGN
E PISCES+PFT/ORGN
E RODENTS+RT/ORGN
E AVES+STD/ORGN
E SALIENTIA+UF/ORGN
E BC25990+USE/ORGN(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.

Field Descriptors for the /ORGN Thesaurus
Code

BC
BT
KT
NOTE
NT
RT
UF
USE

Description
Self
Biosystematic Codes
Broader Term
Keyword Term
Scope Note
Narrower Term
Related Term
Used For Term
Used Term

January 2022

12
TOXCENTER

Supplementary Term (/ST) Thesaurus
All Relationship Codes can be used with both the SEARCH and EXPAND command in the Controlled Term(/ST) thesaurus.
Code
ALL
AUTO (1)
BT
HIE
KT
NOTE
NT
PFT
RT
STD
UF
USE

Content
All associated terms(BT, SELF, NOTE, UF, USE, NT, RT)
Automatic Relationship Code
(SELF, USE)
Broader Terms(BT, SELF)
Hierarchy (Broader and Narrower Terms)(BT, SELF, NT)
Keyword Terms (multiword phrases containing the term)(SELF, KT)
Scope Notes(SELF, NOTE)
Narrower Terms(SELF, NT)
Preferred and Forbidden Terms(SELF, UF, USE)
Related Terms(SELF, RT)
Standard (Broader, Narrower, and Related Terms)(BT, SELF, NT, RT)
Used For Terms (Forbidden Terms)(SELF, UF)
Used Terms (Preferred Terms)(SELF, USE)

ExampleE ANIMAL HUSBANDRY+ALL/ST
E PEDIATRICS+AUTO/ST
E ALLERGY+BT/ST
E HUMAN MEDICINE+HIE/ST
E DENTAL+KT/ST
E DENTAL MEDICINE+NOTE/ST
E AGRICULTURE+NT/ST
E ANTIVIRAL – DRUG+PFT/STE TOXICOLOGY+RT/ST
E CLINICAL IMMUNOLOGY+STD/ST
E ANTIVIRAL – DRUG+UF/ST
E ANTIVIRAL+USE/ST(1) Automatic relationship is SET OFF. When SET REL is ON, the result of EXPAND without any relationship code is the same as
described for AUTO.

Field Descriptors for the /ST Thesaurus
Code

BT
KT
NOTE
NT
RT
UF
USE

January 2022

Description
Self
Broader Term
Keyword Term
Scope Note
Narrower Term
Related Term
Used For Term
Used Term

13
TOXCENTERDISPLAY and PRINT Formats
Any combination of formats may be used to display or print answers. Multiple codes must be separated by
spaces or commas, e.g., D L1 1-5 CN CO. The fields are displayed or printed in the order requested.
Hit-term highlighting is available in all fields except CM, CP, ED, MY, PC, and PY. Highlighting must be ON
during SEARCH to use the HIT, KWIC, and OCC display formats.
FormatAB (1)AN
AU (IN) (2)
AUCL
AUGR
AUID
BC (3)CC (4)CM (5)CN (6)CP (4)CS (7)CSS (8)CT (9)CY (10)DB (11)DE (11)DN
DOI (FTDOI) (29)
DT (TC) (12)ED (UP)
EML (9,13)
EPD (5,13)
EPY (5,13)
FS
GEN (10)
GN (5)
GO (5)GT (3)ISN (13,14)
JT (13,14)
JTA (13,15)
JTF (13,16)
LA (17)
MD (3,13)
ML (3,13)
MO (3,13)
MT (3,13)
MY (3,13)
NA (5)NC (8)NCT
NR (5,13)
ON (18)ORGN (3)OS (19)PC (PCS) (13,20)
PD (13,14)
PI (20, 28) (PN, PATS)
PNK
PY (13,14)
RN (21)RNK (30)RNKM (30)SC (22)

Content
Abstract
Accession Number
Author or Inventor
Collaborator
Group Author
Author Identifier
Biosystematic CodeClassification Code (Concept Code)Comment
Chemical Name
Copyright Notice
Corporate Source (includes ZP)
Supporting Organization (Sponsoring Agency)
Controlled Term
Country of Publication
Duration Begin, Date (Initial Project Date)
Duration End, Date (Final Project Date)
Document Number
Digital Object Identifier
Document Type
Entry and Last Updated Dates
E-mail Address
Electronic Publication Date
Electronic Publication Year
File Segment
Gene Name
Grant Number
Grant Organization
Geographic Term
International Standard (Document) Number (CODEN, ISBN, ISSN)
Journal Title
Journal Title, Abbreviated
Journal Title, Full
Language
Meeting Date
Meeting Location
Meeting Organizer
Meeting Title
Meeting Year
Named Person or Institution
Number of Contract
Clinical Trial Numbers
Number of Report
Order Number
Organism
Other Source
Patent Country
Publication Date
Patent Information
Patent Number/Kind CodePublication Year
CAS Registry Number and Chemical Name
Rank, Relevance Score
Rank Multifiles
SectionExamples
D AB
D AN FS
D AU 1-5
D AUCLD AUGRD AUIDD BC
D CC 1 8
D CM SO
D RN CN
D CP
D CS
D CSS
D CT
D CY
D DB DED DB DE
D DN
D DOI or D FTDOI
D DT
D 1 3 5 ED
D EML AU
D EPD
D EPY
D FS 2,7
D GEN
D GN
D GO
D GT
D ISN
D JT
D JTA
D JTF
D LA
D MD
D ML
D MO
D MT
D MY
D NA
D NC
D NCT
D NR
D ON
D ORGN
D OS
D PC
D PD
D PI
D PNK
D PY
D RN
D RNK
D RNKM
D SC
January 2022

14
TOXCENTERDISPLAY and PRINT Formats (cont'd)FormatSL (23)
SO
ST (24)
TI (25)
UNII (5,13)
URL (3,13)
ZP (26)
ABS
ALL

Content

Examples
D SL
D TI SO
D ST
D TI
D UNII
D URL
D ZP
D ABS
D ALL

CBIB
DALL
IABS
IALL
IBIB
IND
SCAN (25,27)

Summary Language
SourceSupplementary Term
Title
Unique Ingredient Identifier
Uniform Resource Locator
Zip Code
AN, CP, AB
AN, CP, DN, TI, AU, AUID, CS, CSS, ON, NC, PI, SO, DOI, CM, CY, DT, FS,
NCT, OS, LA, SL, ED, DB, DE, AB, SC, CC, BC, CT, ST, NA, GT, ORGN,
RN, CN, UNII, GEN, GO, GN
AUY, AUCL, AUGR
AN, CP, DN, TI, AU, AUID, CS, CSS, ON, NC, PI, SO, DOI, CY, DT, FS, NCT,
OS, LA, SL, ED, DB, DE, GO, GN (BIB is the default)
AN, DN, compressed bibliographic information
ALL, delimited for post processing
ABS, indented with text labels
ALL, indented with text labels
BIB, indented with text labels
AN, CP, SC, CC, BC, CT, ST, NA, GT, ORGN, RN, CN, UNII, GEN
TI, CM, CN (random display without answer numbers)

HIT
HITINDKWIC
OCC (25)

Fields containing hit terms
IND
Hit terms with 20 words on either side (Keyword in Context)
Number of occurrences of hit terms and fields in which they occur

D HIT
D HITINDD KWIC NOH
D OCC 1-6

AUTH
BIB

D AUTHD L2 3 BIB
D CBIBD DALLD IABSD IALLD IBIBD IND
D SCAN(1) Available in all file segments except ANEUPL and ETIC.
(2) Available in all file segments except TSCATS.
(3) Available in BIOSIS file segment only.
(4) Available in BIOSIS, CAPLUS, CIS, IPA, and TSCATS file segments only.
(5) Available in MEDLINE file segment only.
(6) Available in BIOSIS, CAPLUS, DART, EMIC, ETIC, IPA, and MEDLINE file segments.
(7) Available in BIOSIS, CAPLUS, CIS, CRISP, DART, EMIC, FEDRIP, IPA, MEDLINE, PESTAB, AND TSCATS file segments.
(8) Available for CRISP, EPIDEM, FEDRIP file segments only
(9) Available in DART, EMIC, and MEDLINE file segment only.
(10) Available in CAPLUS and MEDLINE file segments only.
(11) Available in FEDRIP file segment only.
(12) Available in ANEUPL, BIOSIS, CAPLUS, CIS, DART, EMIC, ETIC, IPA, MEDLINE and PESTAB file segments.
(13) Custom display only.
(14) Available in all file segments except CRISP, FEDRIP, and TSCATS.
(15) Available in ANEUPL, CAPLUS, DART, EMIC, EPIDEM, ETIC, HAPAB, HMTC, IPA, MEDLINE, PESTAB, PPBIB, and RISKLINE
file segments.
(16) Available in BIOSIS, CAPLUS, DART, ETIC, IPA, MEDLINE, and PESTAB file segments.
(17) Available in all file segments except EPIDEM, PPBIB, and TSCATS.
(18) Available in TSCATS file segment only.
(19) Available in BIOSIS, CAPLUS, EMIC, FEDRIP, IPA, and MEDLINE file segments only.
(20) Available in BIOSIS and CAPLUS file segments only.
(21) Available in all file segments except CRISP and FEDRIP.
(22) Available in IPA file segment only.
(23) Available in BIOSIS and IPA file segments only.
(24) Available in ANEUPL, BIOSIS, CAPLUS, CIS, CRISP, EMIC, EPIDEM, ETIC, FEDRIP, HMTC, IPA, MEDLINE, PPBIB, RISKLINE,
and TSCATS file segments.
(25) No online display fee for this format.
(26) Available for CRISP and FEDRIP file segments only.
(27) SCAN must be specified on the command line, i.e., D SCAN or DISPLAY SCAN.
(28) Patent numbers are available in STN and Derwent format. The format for DISPLAY, PRINT, SELECT, and SORT is set using theSET PATENT command. STN is the default format. Enter SET PAT DERWENT to change to the Derwent format. To reset to the
STN format, enter SET PAT STN.
(29) Available in BIOSIS and MEDLINE file segments only.
(30) The RNK and RNKM formats display only the hit term occurrence ranking for the record, with the following line:
RELEVANCE SCORE ##. RNK is for the single file environment, while RNKM is for the multifile environment.

January 2022

15
TOXCENTER

SELECT, ANALYZE, and SORT Fields
The SELECT command is used to create E-numbers containing terms taken from the specified field in an answer
set.
The ANALYZE command is used to create an L-number containing terms taken from the specified field in an answer
set.
The SORT command is used to rearrange the search results in either alphabetic or numeric order of the specified
field(s).

Field Name
Abstract (2)Accession Number
Author (Inventor) (4)Author Group
Author Identifier
Biosystematic Code (5)CAS Registry Number (6)Chemical Name (7)Chemical Name and CAS Registry Number
Citation
Classification Code (10) (Concept Code)
Clinical Trial Numbers
CODEN
Collaborator
Comment
Controlled Term (10)Corporate Source (12) (Patent Assignee)Country Of Publication (13)Document Number
Document Type (14)Duration Begin, Date (15) (Initial Project Date)
Duration End, Date (15) (Final Project Date)
Electronic Publication Date (24)Electronic Publication Year (24)E-mail Address (11)File Segment
GenBank Number (16)Gene Name
Grant Number
Grant Organization
Group Author
Geographic Term (5)International Standard Book Number
International Standard (Document) Number (17)International Standard Serial Number
Inventor (19)Journal Title, Abbreviated and Full (17)Journal Title, Abbreviated (20)Journal Title, Full (22)Journal Title Code (17)Language (23)Meeting Date (5)Meeting Location (5)Meeting Organizer (5)Meeting Title (5)Meeting Year (5)Named Person or Institution (24)
Number of Contract (25)
Number of Report (26)Field CodeANALYZE/
SELECT (1)

AB
AN
AU
AUTH
AUID
BC
RN
CN
NAME
CHEM
CIT
CC
NCT
CODEN
AUCL
CM
CT
CS
CY
DN
DT
DB
DE
EPD
EPY
EML
FS
GENBANK
GBN
GEN
GN
GO
AUGR
GT
ISBN
ISN
ISSN
IN
JT
JTA
JTF
JTC
LA
MD
ML
MO
MT
MY
NA
NC
NR

Y (3)
Y
Y
Y
Y
Y
Y (3)
Y
Y (3)
Y (3)
Y (8,9)YYNY
Y (8,35)
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y (3)
Y (3)
Y
Y
Y
Y
Y
N
Y (18)NYY
Y (21)Y (21)
N
Y
Y
Y
Y
Y
Y (8)
Y
Y
Y

SORT
N
N
Y
Y
Y
N
N
N
N
N
N
N
Y
Y
Y
N
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
N
N
Y
Y
Y
Y
Y
Y
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
N
Y
Y
January 2022

16
TOXCENTER

SELECT, ANALYZE, and SORT Fields (cont'd)
Field Name
Occurrence Count of Hit Terms
Organism (5)Order Number (27)
Other Source (28)Patent Country (19)Patent Information (19)Patent Number (19)Patent Number/Kind CodePublication Date (18)Publication Year (18)Section (20)
SourceSummary Language (32)Supplementary Term (33)Supporting Organization (25) (Sponsoring Agency)
Title
Treatment Code (14)Uniform Resource Locator (5)Unique Ingredient Identifier (24)
Zip Code (6)(1)

Field CodeANALYZE/
SELECT (1)

SORT

OCC
ORGN
ON
OS
PC
PCS
PI
PN
PATS
PNK
PD
PY
SC
SO
SL
ST
CSS
TI
TC
URL
UNII
ZP

N
Y
Y
Y
Y (8)
Y (8)
Y (29)
Y
Y
Y (8)
Y
Y
Y
Y (8,31)YYY
Y (default)
Y (34)
Y
Y
Y

Y
N
Y
Y
Y
Y
Y
Y
Y
N
Y
Y
Y
N
Y
N
Y
Y
Y
Y
N
Y

HIT may be used to restrict terms extracted to terms that match the search expression used to create the answer set, e.g.,
SEL HIT TI.
(2) Available in all file segments except ANEUPL and ETIC.
(3) Appends /BI to the terms created by SELECT.
(4) Available in all file segments except TSCATS.
(5) Available for the BIOSIS file segment only.
(6) Available in all file segments except CRISP and FEDRIP.
(7) Available in BIOSIS, CAPLUS, DART, EMIC, ETIC, IPA, and MEDLINE file segments.
(8) SELECT HIT and ANALYZE HIT are not valid with this field.
(9) Extracts first author, publication year, volume, and first page with a truncation symbol appended and with /RE appended to theterms created by SELECT.
(10) Available in BIOSIS, CAPLUS, CIS, IPA and TSCATS file segments only.
(11) Available in DART, EMIC, and MEDLINE file segment only.
(12) Available in BIOSIS, CAPLUS, CIS, CRISP, DART, EMIC, FEDRIP, IPA, MEDLINE, PESTAB, AND TSCATS file segments.
(13) Available in CAPLUS and MEDLINE file segments only.
(14) Available in ANEUPL, BIOSIS, CAPLUS, CIS, DART, EMIC, ETIC, IPA, MEDLINE and PESTAB file segments.
(15) Available in FEDRIP file segment only.
(16) Available in BIOSIS and MEDLINE file segments only.
(17) Available in all file segments except CRISP, FEDRIP, and TSCATS.
(18) Selects or analyzes CODEN, ISSN, and ISBN with /ISN appended to the terms created by SELECT.
(19) Available for BIOSIS and CAPLUS file segments only.
(20) Available in ANEUPL, CAPLUS, DART, EMIC, EPIDEM, ETIC, HAPAB, HMTC, IPA, MEDLINE, PESTAB, PPBIB, and RISKLINE
file segments.
(21) Appends /JT to the terms created by SELECT.
(22) Available in BIOSIS, CAPLUS, DART, ETIC, IPA, MEDLINE, and PESTAB file segments.
(23) Available in all file segments except EPIDEM, PPBIB, and TSCATS.
(24) Available in MEDLINE file segment only.
(25) Available for CRISP, EPIDEM, FEDRIP file segments only
(26) Available in MEDLINE file segment only.
(27) Available in TSCATS file segment only.
(28) Available in BIOSIS, CAPLUS, EMIC, FEDRIP, IPA, and MEDLINE file segments only.
(29) Selects or analyzes the patent number and appends /PN to the terms created by SELECT.
(30) Available in IPA file segment only.
(31) Selects or analyzes CODEN, ISSN, and ISBN with /SO appended to the terms created by SELECT.
(32) Available in BIOSIS and IPA file segments only.
(33) Available in ANEUPL, BIOSIS, CAPLUS, CIS, CRISP, EMIC, EPIDEM, ETIC, FEDRIP, HMTC, IPA, MEDLINE, PPBIB, RISKLINE,
and TSCATS file segments.
(34) Appends /DT to the terms created by SELECT.
(35) Selects or analyzes the PMID values with /DN appended.

January 2022

17
TOXCENTER

Sample Records
DISPLAY IALL (BIOSIS File Segment)
ACCESSION NUMBER:COPYRIGHT:
DOCUMENT NUMBER:
TITLE:

2011:95669 TOXCENTER
Copyright (c) 2011 The Thomson Corporation
PREV201100132307
Methods for Genotyping Verotoxin-Producing Escherichia
coli
AUTHOR(S):Karama, M.; Gyles, C. L. [Reprint Author]
CORPORATE SOURCE:
Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada
cgyles@uoguelph.ca
SOURCE:
Zoonoses and Public Health, (OCT 2010) Vol. 57, No. 7-8,
pp. 447-462.
ISSN: 1863-1959.
DIGITAL OBJECT IDENTIFIER: 10.1111/j.1863-2378.2009.01259.x
DOCUMENT TYPE:
ArticleGeneral Review; (Literature Review)
FILE SEGMENT:
BIOSIS
OTHER SOURCE:
BIOSIS 2011:132307
LANGUAGE:
EnglishENTRY DATE:Entered STN: 15 Mar 2011
Last Updated on STN: 15 Mar 2011
ABSTRACT:
Verotoxin-producing Escherichia coli (VTEC) is annually incriminated in morethan 100 000 cases of enteric foodborne human disease and in losses amounting
to $US 2.5 billion every year. A number of genotyping methods have beendeveloped to track VTEC infections and determine diversity and evolutionary
relationships among these microorganisms. These methods have facilitatedmonitoring and surveillance of foodborne VTEC outbreaks and early
identification of outbreaks or clusters of outbreaks. Pulsed-field gelelectrophoresis (PFGE) has been used extensively to track and differentiate
VTEC because of its high discriminatory power, reproducibility and ease ofstandardization. Multiple-locus variable-number tandem-repeats analysis (MLVA)
and microarrays are the latest genotyping methods that have been applied todiscriminate VTEC. MLVA, a simpler and less expensive method, is proving tohave a discriminatory power comparable to that of PFGE. Microarrays are
successfully being applied to differentiate VTEC and make inferences on genome
diversification. Novel methods that are being evaluated for subtyping VTEC
include the detection of single nucleotide polymorphisms and optical mapping.
This review discusses the principles, applications, advantages anddisadvantages of genotyping methods that have been used to differentiate VTEC
strains. These methods have been mainly used to differentiate strains of O157:
H7 VTEC and to a lesser extent non-O157 VTEC.
CLASSIFICATION CODE: Pathology - General
12502
Toxicology - General and methods
22501
Physiology and biochemistry of bacteria
31000
Medical and clinical microbiology - Bacteriology
36002
SUPPLEMENTARY TERMS: Major Concepts
Toxicology; Infection; Methods and Techniques; Human
Medicine (Medical Sciences)
SUPPLEMENTARY TERMS: Diseases
foodborne infection: bacterial disease, toxicity
SUPPLEMENTARY TERMS: Chemicals & Biochemicals
verotoxin: toxin
SUPPLEMENTARY TERMS: Methods & Equipment
genotyping: laboratory techniques, genetic techniques;microarray: laboratory techniques, genetic techniques;
optical mapping: laboratory techniques, genetic
techniques; pulsed-field gel electrophoresis:
electrophoretic techniques, laboratory techniques;
Multiple-locus variable-number tandem-repeats analysis:laboratory techniques, genetic techniques
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
single nucleotide polymorphism
January 2022

18
TOXCENTER
ORGANISM:

ORGANISM:ClassifierEnterobacteriaceae
06702
Super Taxa
Facultatively Anaerobic Gram-Negative Rods; Eubacteria;
Bacteria; Microorganisms
Organism Name
Escherichia coli (species): pathogen, serovar-O157:H7
Taxa Notes
Bacteria, Eubacteria, Microorganisms
Classifier
Hominidae
86215
Super Taxa
Primates; Mammalia; Vertebrata; Chordata; Animalia
Organism Name
human (common): hostTaxa Notes
Animals, Chordates, Humans, Mammals, Primates,
Vertebrates

DISPLAY IALL (CAPLUS File Segment)
ACCESSION NUMBER:COPYRIGHT:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:PATENT INFORMATION:
SOURCE:

COUNTRY:
DOCUMENT TYPE:
FILE SEGMENT:OTHER SOURCE:LANGUAGE:
ENTRY DATE:

2001:187664 TOXCENTER
Copyright 2011 ACS
CA13519271902Z
Methods for assessing complement activation
Hugli, Tony E.; Stoughton, Roland B.
ASSIGNEE: The Scripps Research InstituteUS 6297024 B1 2 Oct 2001
(2001) U.S., 28 pp., Cont.-in-part of U.S. Ser. No.
173,579.
CODEN: USXXAM.
UNITED STATESPatentCAPLUSCAPLUS 2001:719020
EnglishEntered STN: 16 Nov 2001
Last Updated on STN: 19 Mar 2002

ABSTRACT:
Methods for measuring in vivo activation of the lectin pathway by measuring
mannan-binding serine protease activity (MASP) are provided. The methods areaccomplished by C3a and C4a levels in in vitro activated EDTA plasma. In
particular, the increase in C3a and/or C4a as a function of time is anindicator of the amount of activated MASP in EDTA plasma. Methods are also
provided for measuring the alternate and classical pathways of complement
activation, exclusive of the lectin pathway, and thereby disorders associatedtherewith. To perform such measurements, Futhan or other serine proteaseinhibitor is added to blood or plasma, containing a divalent metal ion chelator,
and C3a and C4a are measured.
CLASSIFICATION CODE: 15-4
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
complement activation MASP1 MASP2 lectin pathway; C3a C4aC5a chelator drug screening; transplant rejection
autoimmune disease complement activation
REGISTRY NUMBER:
80295-42-7 (complement C3a)80295-49-4 (complement C4a)80295-54-1 (complement C5a)172306-56-8 (MASP serine protease)214915-11-4 (MASP-1 serine protease)214915-16-9 (MASP-2 serine protease)60-00-4 (EDTA)
37259-58-8 (Serine protease)14127-61-8 (Calcium ion)
REGISTRY NUMBER:
82956-11-4; 77-92-9

January 2022

19
TOXCENTERDISPLAY IALL (IPA File Segment)
ACCESSION NUMBER:COPYRIGHT:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):
SOURCE:DOCUMENT TYPE:
FILE SEGMENT:OTHER SOURCE:LANGUAGE:
ENTRY DATE:

2001:153071 TOXCENTER
Copyright 2001 ASHP
38-10342
Gender gap narrows in smoking prevalence, deathsanon
American Journal of Health-System Pharmacy, (May 152001) Vol. 58, pp. 852, 854.
CODEN: AHSPEK. ISSN: 1079-2082.
Journal
IPA
IPA 2001:10342
EnglishEntered STN: 16 Nov 2001
Last Updated on STN: 16 Nov 2001

ABSTRACT:
It was announced that the gap in smoking prevalence between men and womenhas closed to less than 5 percentage points; women now account for 39% of
all smoking related deaths, a proportion that has more than doubled since
1965, according to the latest U.S. Surgeon General's report on smoking.
Women who smoke not only share the same health risk as men but are also
faced with health consequences that are unique to women, including
pregnancy complications, problems with menstrual function, and cervicalcancer. The report also states that nicotine addiction appears generally
similar between the sexes, however, women's regulation of nicotine intake
may be less precise than men's.
Elvira deC. Weiss
SECTION CODE:
22 Sociology, Economics and Ethics; 4 Toxicity
CLASSIFICATION CODE: 12:00 Autonomic drugs
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
Nicotine; smoking; women
Autonomic drugs; nicotine; women
Smoking; cigarettes; womenCigarettes; smoking; women
Women; smoking; cigarettes
Toxicity; nicotine; women
Sex; consumers; smoking
Death; cigarettes; smoking
Pregnancy; cigarettes; smoking
Cervix neoplasms; cigarettes; smoking
REGISTRY NUMBER:
54-11-5 (Nicotine)DISPLAY IALL (MEDLINE File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):2012:377043 TOXCENTER
PubMed ID: 22336149
Arsenic, organic foods, and brown rice syrup
Jackson Brian P; Taylor Vivien F; Karagas Margaret R;
Punshon Tracy; Cottingham Kathryn L
CORPORATE SOURCE:
Trace Element Analysis Core Laboratory, Department ofEarth Sciences, Dartmouth College, Hanover, New Hampshire
03755, USA BPJ@dartmouth.edu
SOURCE:
Environmental health perspectives, (2012 May) Vol. 120,
No. 5, pp. 623-6. Electronic Publication Date: 13 Feb
2012.
Journal code: 0330411. E-ISSN: 1552-9924. L-ISSN:
0091-6765.
Report No.: NLM-PMC3346791.
DIGITAL OBJECT IDENTIFIER: 10.1289/ehp.1104619
COMMENT:
Comment in: Environ Health Perspect. 2012 May;120(5):A204.
PubMed ID: 22549048
COUNTRY:
United States
DOCUMENT TYPE:
Journal; Article; (JOURNAL ARTICLE)(RESEARCH SUPPORT, N.I.H., EXTRAMURAL)(RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.)
January 2022

20
TOXCENTER
FILE SEGMENT:MEDLINE
OTHER SOURCE:MEDLINE 2012430909
LANGUAGE:
EnglishABSTRACT:BACKGROUND: Rice can be a major source of inorganic arsenic (Asi) for many
sub-populations. Rice products are also used as ingredients in prepared foods,
some of which may not be obviously rice based. Organic brown rice syrup (OBRS)
is used as a sweetener in organic food products as an alternative tohigh-fructose corn syrup. We hypothesized that OBRS introduces As into theseproducts.
OBJECTIVE: We determined the concentration and speciation of As incommercially available brown rice syrups and in products containing OBRS,
including toddler formula, cereal/energy bars, and high-energy foods used byendurance athletes.
METHODS: We used inductively coupled plasma mass spectrometry (ICP-MS) and ion
chromatography coupled to ICP-MS to determine total As (Astotal) concentrations
and As speciation in products purchased via the Internet or in stores in the
Hanover, New Hampshire, area. Discussion: We found that OBRS can contain highconcentrations of Asi and dimethyl-arsenate (DMA). An "organic" toddler milk
formula containing OBRS as the primary ingredient had Astotal concentrations up
to six times the U.S. Environmental Protection Agency safe drinking water
limit. Cereal bars and high-energy foods containing OBRS also had higher As
concentrations than equivalent products that did not contain OBRS. Asi was themain As species in most food products tested in this study.
CONCLUSIONS: There are currently no U.S. regulations applicable to As in food,but our findings suggest that the OBRS products we evaluated may introduce
significant concentrations of Asi into an individual's diet. Thus, we conclude
that there is an urgent need for regulatory limits on As in food.
CONTROLLED TERM:*Arsenic: AN, analysis
Cereals: CH, chemistryChild
Child, Preschool*Food Contamination: AN, analysis
HumansInfant*Oryza sativa: CH, chemistry*Sweetening Agents
REGISTRY NUMBER:
7440-38-2 (Arsenic)
CHEMICAL NAME:
Sweetening Agents
UNIQ INGREDIENT ID: N712M78A8G
GRANT ORGANIZATION: United States NIEHS NIH HHS
GRANT NUMBER:
P20 ES018175; P42 ES007373
DISPLAY IALL (ANEUPL File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:

2002:348890 TOXCENTER
ANEUPL-83-001787
MICROTUBULE ORGANIZING CENTERS DURING THE CELL CYCLE OF
3T3 CELLS.
AUTHOR(S):BROOKS R F; RICHMOND F N
SOURCE:
Journal of Cell Science, (1983) 61 231.
CODEN: JNCSA.
FILE SEGMENT:ANEUPLLANGUAGE:
EnglishENTRY DATE:Entered STN: Dec 2002
Last Updated on STN: Dec 2002
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
AGENT TEST RESULTS; MAMMAL MOUSE CELL CULTURE; COLCEMIDREGISTRY NUMBER:
477-30-5

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ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:
SOURCE:DOCUMENT TYPE:
FILE SEGMENT:LANGUAGE:
ENTRY DATE:

2002:523046 TOXCENTER
CIS-01-01633
Toxicological profile for alpha-, beta-, gamma- anddelta-hexachlorocyclohexane (Update)
Anonymous
Agency for Toxic Substances and Diseases Registry (ATSDR)
U.S. Department of Health and Human Services, Public
Health Service, Agency for Toxic Substances and Disease
Registry, Division of Toxicology/Toxicology Information
Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333,
USA, July 1999. xix, 273p. Illus. Approx. 860 ref..
Book; (Monograph)
CIS
EnglishEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:This profile was prepared in accordance with guidelines set by the US Agency
for Toxic Substances and Disease Registry and the EPA. The key literature
related to the toxic effects of hexachlorocyclohexane is identified andreviewed. Contents: public health statement; health effects; chemical andphysical information; production, import, use and disposal; potential for human
exposure; analytical methods; regulations and advisories; glossary. Healthhazards include: neurologic effects (dizziness, seizures); haematologicalchanges; effects on the immune system; liver and kidney damage; changes in
reproductive hormone levels in the blood; animal studies show reproductive
effects, genotoxicity and cancerogenicity (liver cancer). (Update of CIS
99-234).
CLASSIFICATION CODE: 120
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
HEXACHLOROCYCLOHEXANE; TOXICOLOGY; TOXICITY EVALUATION;HEALTH HAZARDS; USA; CRITERIA DOCUMENT; TOXIC EFFECTS;
LITERATURE SURVEY; EXPOSURE EVALUATION; LIMITATION OF
EXPOSURE; GLOSSARY; SKIN ABSORPTION; NEUROLOGICAL EFFECTS;
CARCINOGENIC EFFECTS; HAEMATOLOGICAL EFFECTS; IMMUNOTOXICEFFECTS; MUTAGENIC EFFECTS; ANTIFERTILITY EFFECTS; HEPATICDAMAGE; RENAL DAMAGE; DETERMINATION IN BIOLOGICAL MATTER;LEGISLATIONREGISTRY NUMBER:
319-84-6; 319-85-7; 319-86-8; 58-89-9; 608-73-1
DISPLAY IALL (CRISP File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:

2002:562111 TOXCENTERCRISP-2000-TW00927-03
TAXOL EFFECTS ON SIGNALING PATHWAYS IN OVARIAN CELLSHORWITZ S B
ALBERT EINSTEIN COLL OF MED, 1300 MORRIS PARK AVENUE,
BRONX, NY 10461:NEW YORKSUPPORTING ORGANIZATION (SPONSORING AGENCY): U.S. DEPT. OF HEALTH AND HUMANSERVICES; PUBLIC HEALTH SERVICE; NATIONAL INSTITUTES OFHEALTH, FOGARTY INTERNATIONAL CENTER
SOURCE:
Crisp Data Base National Institutes of Health.
DOCUMENT TYPE:(Research)
FILE SEGMENT:CRISPLANGUAGE:
EnglishENTRY DATE:Entered STN: Dec 2002
Last Updated on STN: Dec 2002
ABSTRACT:DESCRIPTION Taxol is a natural product which has significant antitumor
activity in a large number of human tumors. It has recently become appreciatedthat in addition to stabilizing microtubules and blocking cell cycle progress,
taxol can alter gene expression by interacting with the MAP-kinase signaltransduction pathway. Previous studies from the foreign and US PIs had
demonstrated that tyrosine phosphorylation of the adaptor protein, Shc, andJanuary 2022

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formation of Shc/grb2/SOS complexes occurs in a taxol-treated murine macrophagecell line. The investigators propose to extend these observations to examine
human ovarian carcinoma cells. The specific aims are to: 1. Study the effectof taxol on activation of the MAP-kinase pathway in human ovarian carcinoma
cell lines; 2. Study the effect of taxotere and other taxol analogs comparedto that of taxol on the activation of the Ras/MAPK signaling pathway and therelationship of this activity to effects on microtubule stabilization andcytotoxicity; 3. Compare taxol and taxotere in MAPK signaling pathway intaxol-sensitive and taxol-resistant human ovarian carcinoma cells.
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
paclitaxel; antineoplastic; biological signaltransduction; microtubule; chemical structure function;
pharmacokinetics; drug adverse effect; drug resistance;
drug screening ,evaluation; gene expression; human tissue;
immunoprecipitation; phosphorylation; electrophoresis;
tissue ,cell culture; cytotoxicity; analog; apoptosis;
enzyme activity; mitogen activated protein kinase; cellproliferation
DISPLAY IALL (DART File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:

SOURCE:DOCUMENT TYPE:
FILE SEGMENT:LANGUAGE:
ENTRY DATE:

2002:582299 TOXCENTER
DART-TER-2001532
Basic fibroblast growth factor (bFGF) induces branchingand dilatation of developing renal tubules leading to cyst
formation.
Li Z; Liu X H; Xu L; Jerebstova M; Ye X; Ray P E
Centers for Molecular Physiology and Genetic Medicine,Children's Research Institute, Children's National Medical
Center, Washington, DC.
Pediatr Res 2002 Apr;51(4 Pt 2):435A. PEDIATRIC RESEARCH,
ISSN: 0031-3998.
Abstract; (MEETING ABSTRACT)DARTEnglishEntered STN: Dec 2002
Last Updated on STN: Dec 2002

DISPLAY IALL (DART File Segment) (cont'd)
ABSTRACT:BACKGROUND: Increased expression of bFGF has been detected in dysplastic
kidneys. However, the role of bFGF and the signaling pathways modulating its
activity in developing kidneys are not completely understood. OBJECTIVE: To
determine whether bFGF modulates the growth of rat metanephric kidneys (MK) anddefine the signaling pathways involved in this process. DESIGN/METHODS: MK (n= 80) from 15 day old rat embryos were grown in serum free DMEM-F12 media in
the presence or absence of bFGF (5-20 ng/mL), bFGF neutralizing antibodies,
8-Bromo-cAMP (10(-3) M) and Isoproterenol (10(-5) M). Immunohistochemistry andin situ hybridization studies were done using the following markers of celldifferentiation: WT-1, Pax, Factor VIII, BF-2; alpha-smooth muscle action,
vimentin, Dolichos biflorus agglutinin. Cell apoptosis and proliferation weredetected with the TUNEL assay, PCNA, (3H)-thymidine, and cell counts. The
number and length of branching developing tubules were measured by morphometricanalysis using a computerized program. Cultured primary stromal mesenchymal
cells (SMC) were grown and treated as described above for the MK. MAPK kinase(MEK 1-2) and cAMP activity were determined by Western blots and ELISA
respectively. To determine the effects of bFGF in vivo, MK were infected withrAd vectors carrying either a secreted 18 kD form of bFGF or the
beta-galactosidase gene, and transplanted under the kidney capsule of adultrats (n = 6 each group). Results were evaluated by one-way analysis ofvariance using the Newman-Keuls test. P values of less than 0.05 wereconsidered significant. RESULTS: Basic FGF increased the branching ofdeveloping tubules and induced the growth of peritubular mesenchymal stromaland endothelial cells. These changes were partially inhibited by 8-Bromo-cAMP
and Isoproterenol. Basic FGF increased (5 folds) the number of SMC through a
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MEK 1-2-dependent signaling pathway. cAMP blocked these effects. Transplanted
MK infected with rAd-bFGF, but not with rAd-beta-gal, showed increased renal
growth, angiogenesis, tubulogenesis, and formation of cystic structures.
CONCLUSIONS: Basic FGF induces renal growth and facilitates the formation of
tubular cystic structures at least partially through a MEK 1-2-dependent
signaling pathway that could be inhibited by cAMP, both in vitro and in in
vivo.
CONTROLLED TERM:
Check Tags: Animal
Rats*Fibroblast Growth Factor 2: PH, PHYSIOLOGY*Kidney Tubules: EM, EMBRYOLOGY*Kidney Tubules: CY, CYTOLOGY*Kidney Tubules: EN, ENZYMOLOGY
Tissue Culture
Cell Division
Apoptosis
Mitogen-Activated Protein Kinases: ME, METABOLISM
Immunohistochemistry
Enzyme-Linked Immunosorbent Assay
Blotting, Western
Signal Transduction
REGISTRY NUMBER:
103107-01-3 (Fibroblast growth factor 2)
CHEMICAL NAME:
EC 2.7.1.- (Mitogen-activated protein kinases)
DISPLAY IALL (EMIC File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:

SOURCE:DOCUMENT TYPE:
FILE SEGMENT:OTHER SOURCE:LANGUAGE:
ENTRY DATE:

2002:453936 TOXCENTER
EMIC-110877
Impact of dimethyl sulfoxide and examples of combined
genotoxicity in the SOS chromotest.
Gebel T; Koenig A
Medical Institute of General Hygiene and Environmental
Health, University of Goettingen, Windausweg 2, D-37073,
Goettingen, Germany. tgebel@gwdg.de
Mutation Research, (1999 Aug 18) 444 (2) 405-11.
Journal Code: NNA. ISSN: 0027-5107.
Journal; Article; (JOURNAL ARTICLE)
EMIC
EMIC MED-99453366
EnglishEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:The bacterial SOS chromotest with Escherichia coli PQ37 was used for theassessment of genotoxicity of combined xenobiotic treatments. The modulationof test compound genotoxicity by dimethyl sulfoxide (DMSO), a common solvent
for test compounds, was assessed as well. It was shown that DMSO modulated SOS
chromotest genotoxicity of several xenobiotics: in comparison to test compound
dissolution in water, the commonly used addition of 3.2% (v/v) DMSO as solvent
lead to a significant increase in the genotoxicity of K(2)RhCl(5) andbeta-propiolactone (BPL). However, the effects of cisplatin decreased
significantly when DMSO was added. Thus, albeit DMSO is not genotoxic in thistest itself, it can interfere with SOS chromotest responses. Further
experiments were performed in the absence of DMSO. BPL and cisplatin in
combination showed an over-additive synergism in SOS genotoxicity as well as
K(2)RhCl(5) and cisplatin did. Addition of Pd(NH(3))(4)Cl(2) and NaAsO(2),which are non-genotoxic in the SOS chromotest, did not enhance the K(2)RhCl(5)or BPL-mediated SOS sfiA induction. Nevertheless, at the highest subcytotoxic
dose of NaAsO(2) tested (200 microM), a slight yet significant suppression of
BPL-mediated SOS genotoxicity was observed. These results confirm that the SOS
chromotest is a useful tool for the rapid evaluation of the combined
genotoxicity of compound mixtures. However, the use of DMSO as test solvent
has to be taken with caution.
CONTROLLED TERM:
Cisplatin: TO, TOXICITY
Colorimetry*Dimethyl Sulfoxide: PD, PHARMACOLOGY
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TOXCENTER*Escherichia coli: DE, DRUG EFFECTS*Escherichia coli: GE, GENETICS*Mutagenicity Tests*SOS Response (Genetics): DE, DRUG EFFECTS
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
Taxonomic Name: ESCHERICHIA COLI,PQ37
Test Object: BACTERIAEFFECTS ON NUCLEIC ACIDS: DNA DAMAGE-SOS INDUCTION-SFIAMISCELLANEOUS CATEGORY: AGENT INTERACTIONSREGISTRY NUMBER:
67-68-5 (DMSO)
57-57-8 (BETA-PROPIOLACTONE)
15663-27-1 (CISPLATIN)
65980-75-8 (DIPOTATASSIUM PENTACHLORORHODATE)
13815-17-3 (TETRAAMMINEPALLADIUM(2+) DICHLORIDE)
7784-46-5 (SODIUM ARSENITE)DISPLAY IALL (EPIDEM File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):
SOURCE:DOCUMENT TYPE:
FILE SEGMENT:ENTRY DATE:

2002:352326 TOXCENTER
EPIDEM-008891
THE RELATION OF DIET, CIGARETTE SMOKING, AND ALCOHOLCONSUMPTION TO PLASMA BETA-CAROTENE AND ALPHA-TOCOPHEROLLEVELS.
STRYKER W S; KAPLAN L A; STEIN E A; STAMPFER M J; SOBER A;WILLETT W C
AM. J. EPIDEMIOL., (1988) 127 (2) 283-296.
JournalEPIDEMEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:THE RELATION OF DIET AND NUTRITIONAL SUPPLEMENTS, CIGARETTE USE, ALCOHOLCONSUMPTION, AND BLOOD LIPIDS TO PLASMA LEVELS OF BETA-CAROTENE AND
ALPHA-TOCOPHEROL WAS STUDIED AMONG 330 MEN AND WOMEN AGED 18-79 YEARS. DIETARYCAROTENE, PREFORMED VITAMIN A, AND VITAMIN E INTAKE WERE ESTIMATED BY A
SELF-ADMINISTERED SEMIQUANTITATIVE FOOD FREQUENCY QUESTIONNAIRE. THE
CORRELATION OF DIETARY CAROTENE WITH PLASMA BETA-CAROTENE WAS REDUCED IN
SMOKERS COMPARED WITH NONSMOKERS (R = 0.02 VS. 0.44 AMONG MEN; R = 0.19 VS.
0.45 AMONG WOMEN). SMOKERS HAD MUCH LOWER PLASMA LEVELS OF BETA-CAROTENE THAN
DID NONSMOKERS (GEOMETRIC MEAN 8.5 VS. 15.3 MICROGRAMS FOR MEN; 17.3 VS. 26.3
MICROGRAMS/DL FOR WOMEN) DESPITE ONLY SLIGHTLY LOWER INTAKES OF CAROTENOIDS.
IN MULTIPLE REGRESSION ANALYSES, MEN WHO SMOKED ONE PACK PER DAY HAD 72% (95%
CONFIDENCE INTERVAL (CI) 58-89) OF THE PLASMA BETA-CAROTENE LEVELS OFNONSMOKERS AFTER ACCOUNTING FOR DIETARY CAROTENE AND OTHER VARIABLES; FORWOMEN, THE CORRESPONDING PERCENTAGE WAS 79% (CI 64-99). IN SIMILAR MODELS, MENDRINKING 20 G OF ALCOHOL PER DAY HAD 76% (CI 65-88) OF THE BETA-CAROTENE LEVELSOF NONDRINKERS; WOMEN HAD 89% (CI 73-108) OF THE LEVELS OF NONDRINKERS. AN
INTERACTION TERM FOR CAROTENE INTAKE AND SMOKING WAS STATISTICALLY SIGNIFICANTIN A MODEL COMBINING BOTH SEXES. THESE RESULTS SUGGEST THAT PLASMA LEVELS OF
BETA-CAROTENE AMONG SMOKERS AND, PERHAPS, HEAVY CONSUMERS OF ALCOHOL MAY BE
REDUCED SUBSTANTIALLY BELOW LEVELS DUE TO DIFFERENCES IN DIET. THE CORRELATIONOF CALORIE-ADJUSTED INTAKE OF VITAMIN E WITH LIPID-ADJUSTED PLASMA LEVELS OF
VITAMIN ALPHA-TOCOPHEROL WAS 0.53 FOR MEN (N = 137) AND 0.51 FOR WOMEN (N =193) AND DID NOT DIFFER BY ALCOHOL CONSUMPTION AND CIGARETTE USE; THESE
CORRELATIONS WERE LARGELY ACCOUNTED FOR BY USE OF VITAMIN SUPPLEMENTS. IN
LINEAR REGRESSION MODELS, VITAMIN E INTAKE AND PLASMA LIPIDS WERE SIGNIFICANT
PREDICTORS OF PLASMA ALPHA-TOCOPHEROL LEVELS./DRUG THERAPY
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
VITAMIN E; CAROTENE; LYCOPENE; BETA-CAROTENE; VITAMIN A;
ADOLESCENCE; ADULT; AGED; ALCOHOL DRINKING; ADMINISTRATION
AND DOSAGE; BLOOD; CROSS SECTIONAL STUDIES; DIET; FEMALE;
HUMAN; MALE; MIDDLE AGE; SMOKING; ANALYSIS; PLASMA;
NUTRITION; EPIDEMIOLOGIC METHODS; LIPIDS; BODY WEIGHT;
STATISTICS; CALORIC INTAKEREGISTRY NUMBER:
59-02-9; 36-88-4; 502-65-8; 7235-40-7; 68-26-8

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TOXCENTERDISPLAY IALL (ETIC File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):2002:503699 TOXCENTERETICBACK-49739
EFFECTS OF TERBUTALINE SULFATE ON FETAL CARDIAC FUNCTIONPETERSEN R; CARTER L S; CHESCHEIR N C; KATZ V L; CEFALO R
C
SOURCE:AM J OBSTET GYNECOL, (1989) (161) 509-512.
CODEN: AJOGA.
DOCUMENT TYPE:
JournalFILE SEGMENT:ETICLANGUAGE:
EnglishENTRY DATE:Entered STN: Dec 2002
Last Updated on STN: Dec 2002
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
Taxonomic Name: CAVIA PORCELLUS, HARTLEY
Test Object: MAMMAL, GUINEA PIG
Assay Method: VIABILITY, FERTILITY AND MORTALITY;CARDIOVASCULAR SYSTEM; GROWTH
Maternal Effects: MATERNAL WEIGHT CHANGES; MATERNALCARDIOVASCULAR SYSTEM
Route Of Administration: SUBCUTANEOUS; INTRAPERITONEALREGISTRY NUMBER:
23031-32-5 (TERBUTALINE SULFATE)
9005-49-6 (HEPARIN)DISPLAY IALL (FEDRIP File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:

2003:105024 TOXCENTERFEDRIP-00199078
Neuropsychological Functioning in Persian Gulf War Era
Veterans
AUTHOR(S):White Roberta F., Ph.D.
CORPORATE SOURCE:
110326; Department of Veterans Affairs Research andDevelopment (15), 810 Vermont Ave. N.W., Washington, D.C.
20420 United States of America
FILE SEGMENT:FEDRIPOTHER SOURCE:
FEDRIP 200301-000167
LANGUAGE:
EnglishENTRY DATE:Entered STN: 6 May 2003
Last Updated on STN: 6 May 2003
BEGIN DATE (INITIAL PROJECT YEAR): 19960501
ABSTRACT:PERSIAN GULF SYNDROME; INTERVIEWS; ENVIRONMENTAL EXPOSURE; AFFECTIVE SYMPTOMS
Abstract Many Persian Gulf War (PGW) veterans have reported a significant
decline in their health since returning from the War. These symptoms haveincluded excessive fatigue skin rash, Joint pain, headaches, and disturbancesof concentration and memory according to the Persian Gulf Registryquestionnaires completed by 12,774 veterans. These veterans may have been
exposed to several neurotoxicants ranging from diesel fuels, oil fire smoke,
pesticides, and biological or chemical weapons. In addition, some of thereported health symptoms overlap with symptoms of post-traumatic stressdisorder (PTSD), multiple chemical sensitivity (MCS), and chronic fatigue
syndrome (CFS). Cognitive impairments have been noted in exposures to thepreviously mentioned neurotoxicants and in the three disorders noted above. In
order to document these impairments in PGW veterans, neuropsychological testsof known validity and sensitivity have been used. OBJECTIVES: This study
evaluates the neuropsychological functioning of PGW-era veterans who areseeking treatment for any type of health or adjustment complaint. PGW deployedveterans will be compared with non-deployed veterans. The purpose of the groupcomparisons is to isolate factors that may differentiate Persian Gulf War
veterans from non-Gulf War veterans who served during the same time period. In
this way, we hope to better understand the constellation of health complaints
popularly referred to as Gulf War Syndrome." RESEARCH PLAN/ METHODS: Allresearch subjects will be administered the previously mentioned
neuropsychological battery. In addition, a standardized set of questionnaires
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TOXCENTER
and interviews will also be administered to identify health symptoms including
physical and mental health conditions. These instruments permit diagnosis
PTSD, MCS, CFS and other psychiatric disorders. The PGW veterans will becompared with non deployed veterans. Data from these groups will also becompared with those from a non-treatment seeking research sample of PGWveterans who are being studied using the same neuropsychological instruments.
FINDINGS: The project's funding has ceased however, we are currently in a
non-funded extension period in order to complete the data collection phase. To
date, there are 137 subjects enrolled in the studs including 121 men and 16
women. As per Pi this project has ended as of 12/99.
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
FEDRIP; RPROJ; va; U.S. DEPT. OF VETERANS AFFAIRS; PERSIANGULF SYNDROME INTERVIEWS ENVIRONMENTAL EXPOSURE AFFECTIVE
SYMPTOMSDISPLAY IALL (HAPAB File Segment)
L11 ANSWER 2 OF 5987 TOXCENTER COPYRIGHT 2002 ACSACCESSION NUMBER:
2002:311239 TOXCENTERDOCUMENT NUMBER:
HAPAB-72-02714
TITLE:
Determination of total bromine and of bromate in barleyand malt.
AUTHOR(S):
Brookes P A; Martin P A
SOURCE:
J. Inst. Brewing London, (1972) 78 (2) 165-169. Ref: 17.
FILE SEGMENT:
HAPAB
ENTRY DATE:Entered STN: Dec 2002
Last Updated on STN: Dec 2002
ABSTRACT:
Improved techniques for the determination of bromine and bromate in barley andmalt were devised since published methods were found unsatisfactory. Bromate
was determined directly on an aqueous extract of barley using an iodometricamplification reaction. Sodium molybdate/potassium fluoride reagent, potassium
iodide solution, sulfuric acid, and starch solution were added to the extract
and a titration was carried out with 0.02N sodium thiosulfate. Recoveries
ranged from over 100% in wheat flour pellets and barley to as low as 85% in
malt flour. Total bromine was determined using the same reaction after ashing
the sample in an oxygen combustion flask and oxidizing the resulting bromide to
bromate. It was necessary to dry steeped and germinating barleys for four hr
at 105 DEG in order to grind samples and obtain satisfactory combustion. 1972
REGISTRY NUMBER:
7726-95-6
DISPLAY IALL (HMTC File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):
SOURCE:
FILE SEGMENT:LANGUAGE:
ENTRY DATE:

2002:353910 TOXCENTER
HMTC-94-0001885
EVALUATION OF XE-340 AS A TRAPPING MEDIUM FOR AIRBORNE
ORGANOCHLORINE PESTICIDES
Yeboah P O; Kilgore W W
Bulletin of Environmental Contamination and Toxicology
33(l):13-19, (1984)***HMTC***
EnglishEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:
Amberlite XAD, a porous polymer sorbent, is the most popular and least
expensive commercial sampling system available to evaluate airborneorganochlorine pesticides. However, its presampling cleanup procedure islengthy. An alternative system which is just as effective but lesstime-consuming than XAD is the XE-340 system. XE-340 is a solid sorbent thatincorporates activated carbon and polymeric principles. This paper presents
the results of XE-340 sampling efficiency tests using seven organochlorine
pesticides: alphachlordane, gamma-chlordane, lindane, heptachlor, heptachlor
expoxide, aldrin, and dieldrin. Vapor pressures, fortification levels, andpercent recoveries are presented.
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
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REGISTRY NUMBER:

alpha-chlordane; gamma-chlordane; U036; lindane; U129;
heptachlor; U129; dieldrim; P037; Characteristics;
Monitoring; Substance Identification; Chemical Industry;
Agricultural Chemicals; Pesticides; Monitoring Methods;
Air Analysis; Halogenated Organics
319-84-6

DISPLAY IALL (PESTAB File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):CORPORATE SOURCE:
SOURCE:DOCUMENT TYPE:
FILE SEGMENT:ENTRY DATE:

2002:346703 TOXCENTERPESTAB-81-2783
Hydrogen peroxide and hydroxyl radical: intermediates inindirect photolysis reactions in water.
Draper W M; Crosby D G
Dep. Anim. Dairy & Vet. Sci., Utah State Univ., Logan, UT
84322
Journal of Agricultural and Food Chemistry, (1981) 29 (4)699-702. Ref: 22.
CODEN: JAFCA.
(Periodical)
PESTAB
Entered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:
Thiobencarb (benthiocarb; I) photodecomposes slowly to thiobencarb S-oxide (II)in aqueous solutions exposed to sunlight. The rate of photodecomposition of I
in water was greatly increased by addition of small amounts of hydrogen
peroxide, tryptophan, or methylene blue. In these solutions,
2-hydroxythiobencarb (III), 3-hydroxythiobencarb (V), II, andN-monoethylthiobencarb (IV) were isolated as photooxidation products of I; thedistributions of these products were similar in each case. Thiobencarb did notundergo reaction with photochemically generated, singlet molecular oxygen but
was oxidized by hydroxyl radical (Fenton's reagent) to III, V, and II. The
free radical photooxidation of I in aqueous acetone was unique; II and IV wereamong the photoproducts but the phenols, III and V, were absent. These results
demonstrate the involvement and common intermediacy of hydrogen peroxide andhydroxyl radical in indirect photolysis reactions in aqueous solutions ofhydrogen peroxide, tryptophan, and methylene blue. (Author abstract reprinted
by permission of the American Chemical Society.)
REGISTRY NUMBER:
28249-77-6
DISPLAY IALL (PPBIB File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):
SOURCE:
FILE SEGMENT:ENTRY DATE:

2002:351132 TOXCENTERPPBIB-03654
Trans-4-hydroxy-2-hexenal: A reactive metabolite from themacrocyclic pyrrolizidine alkaloid senecionine.
Segall H J; Wilson D W; Dallas J L; Haddon W F
Science, (1985) 229 (Aug 2) 472-475.
PPBIBEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:The toxicity of macrocyclic pyrrolizidine alkaloids in the livers of man andanimals has been attributed to the formation of reactive pyrroles fromdihydropyrrolizines. Now a novel metabolite, trans-4-hydroxy-2-hexenal, hasbeen isolated from the macrocyclic pyrrolizidine alkaloid senecionine, in an invitro hepatic microsomal system. Other alkenals such as trans-4-hydroxy-2nonenal have previously been isolated from microsomal systems when treated withhalogenated hydrocarbons or subjected to lipid peroxidation. The in vivo
pathology caused by trans-4-hydroxy-2-hexenal appears to be identical to that
previously attributed to reactive pyrroles. there are similarities between the
toxic effects of this alkenal and those of centrilobular hepatotoxins such as
CCl4 and other alkenals formed during lipid peroxidation.
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
Chemical analysis; Senecio; Compositae; Liver; Hepatic
January 2022

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REGISTRY NUMBER:

microsomal enzyme; Centrilobular necrosis; Hepatotoxic
130-01-8

DISPLAY IALL (RISKLINE File Segment)
ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:AUTHOR(S):
SOURCE:
FILE SEGMENT:LANGUAGE:
ENTRY DATE:

2002:624842 TOXCENTER Full-text
RISKLINE-2001120009
Toxicology and carcinogenesis studies ofp,p'-Dichlorodiphenyl sulfone in F344/N rats and B6C3F1
mice (feed studies)
Anonymous
National Toxicology Program Technical Report Series,(2001) 501 262 p.
RISKLINE
EnglishEntered STN: 13 Jul 2004
Last Updated on STN: 29 Nov 2005

ABSTRACT:p,p'-Dichlorodiphenyl sulfone is used as a starting material in the productionof polysulfones and polyethersulfones and as a component in reactive dyes inthe textile industry; it is also a by-product of pesticide production.
p,p'-Dichlorodiphenyl sulfone was nominated for study by the National Cancer
Institute because of its history of high production and use, the prospect ofincreased production and use, and the absence of adequate toxicity testing.
Male and female F344/N rats and B6C3F, mice were exposed top,p'-dichlorodiphenyl sulfone (greater than 99% pure) in feed for 14 weeks or 2
years. Genetic toxicology studies were conducted in Salmonella typhimurium,
cultured Chinese hamster ovary cells, and mouse bone marrow. 14-week study inrats. Groups of 10 male and 10 female F344/N rats were fed diets containing 0,30, 100, 300, 1,000, or 3,000 ppm p,p'-dichlorodiphenyl sulfone (equivalent toaverage daily doses of approximately 2, 6, 19, 65, or 200 mg
p,p'-dichlorodiphenyl sulfone/kg body weight) for 14 weeks. All rats survived
until the end of the study. Mean body weights of groups exposed to 300 ppm orgreater were significantly less than those of the controls. Liver weights ofgroups exposed to 100 ppm or greater and kidney weights of 1,000 and 3,000 ppm
male rats were significantly greater than those of the controls. Centrilobular
hepatocyte hypertrophy of the liver was observed in most male rats exposed to
100 ppm or greater and in all female rats exposed to 300 ppm or greater, andthe severities were increased in 300 ppm males and 1,000 and 3,000 ppm males
and females. The incidences of nephropathy in 1,000 and 3,000 ppm female rats
were significantly increased. Dose-related increases in severity ofnephropathy were observed in male rats. 14-week study in mice. Groups of 10
male and 10 female B6C3F1 mice were fed diets containing 0, 30, 100, 300,
1,000, or 3,000 ppm p,p'-dichlorodiphenyl sulfone (equivalent to average daily
doses of approximately 3.5, 15, 50, 165, or 480 mg/kg) for 14 weeks. All micesurvived until the end of the study. Mean body weights of groups exposed to
300 ppm or greater were significantly less than those of the controls. Liverweights of groups exposed to 300 ppm or greater were significantly increased.
Centrilobular hypertrophy of the liver was observed in most males exposed to
100 ppm or greater and in all females exposed to 1,000 or 3,000 ppm, and theseverities generally increased with increasing exposure concentration. 2-year
study in rats. Groups of 50 male and 50 female rats were fed diets containing
0,10 (males), 30,100, or 300 (females) ppm p,p'-dichlorodiphenyl sulfone for
105 weeks. Dietary concentrations of 10, 30, and 100 ppm resulted in average
daily doses of approximately 0.5, 1.5, and 5.0 mg/kg to males. Dietaryconcentrations of 30, 100, and 300 ppm resulted in average daily doses ofapproximately 1.6, 5.4, and 17 mg/kg to females. Additional groups of 10 maleand 10 female rats were fed the same p,p'-dichlorodiphenyl sulfone-containing
diets for 18 months and bled for plasma determinations of p,p'-dichlorodiphenyl
sulfone at approximately 2 weeks and 3, 12, and 18 months. Survival of all
exposed groups of male and female rats was similar to that of the control
groups. Mean body weights of 30 and 100 ppm males were generally less thanthose of the controls during the latter part of the study, and mean bodyweights of 100 and 300 ppm female rats were less from weeks 30 and 18,
respectively. Feed consumption by the exposed groups was similar to that by
the controls throughout the study. The incidences of centrilobular hepatocyte
January 2022

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hypertrophy in 100 ppm male and 100 and 300 ppm female rats were significantly
greater than those in the controls. The incidences of bile duct hyperplasia
and centrilobular degeneration were also significantly increased in 100 and 300
ppm females. No neoplasms were related to chemical exposure. 2-year study inmice. Groups of 50 male and 50 female mice were fed diets containing 0, 30,
100, or 300 ppm p,p'-dichlorodiphenyl sulfone for 105 to 106 weeks. Dietaryconcentrations of 30, 100, and 300 ppm delivered average daily doses ofapproximately 4, 13, and 40 mg/kg to males and approximately 3, 10, and 33
mg/kg to females. Additional groups of 10 male and 10 female mice were fed thesame p,p'-dichlorodiphenyl sulfone-containing diets for up to 12 months; three
mice in each group were bled for plasma determinations of
p,p'-dichloro-diphenyl sulfone at approximately 2 weeks or 3 or 12 months.
Survival of all exposed groups of male and female mice was similar to that of
the control groups. Mean body weights of 300 ppm mice were less than those of
the controls throughout most of the study. Feed consumetion by the exposedgroups was similar to that by the controls throughout the study. The
incidences of centdlobular hepatocyte hypertrophy in all exposed groups of malemice and in 100 and 300 ppm females were significantly greater than those in
the controls. The incidence of eosinophilic foci in 300 ppm females was
significantly increased. No neoplasms were related to chemical exposure.
Pharmacokinetics. Of p,p'-Dichlorodiphenyl sulfone. p,p'-Dichlorodiphenyl
sulfone is rapidly absorbed from the gut and metabolized by a saturable
process. Although some p,p'-dichlorodiphenyl sulfone is eliminated unchanged
in feces and urine, most of the elimination is via metabolism. Mathematicalmodeling of the toxicokinetics supports the view that p,p'-dichlorodiphenyl
sulfone induces enzymes involved in its metabolism. Genetic toxicology.
p,p'-Dichlorodiphenyl sulfone was not mutagenic in any of several strains ofSalmonella typhimurium, with or without metabolic activation enzymes (S9).
Results of the sister chromatid exchange test in cultured Chinese hamster ovary
cells were judged to be negative in the presence of S9 and equivocal in theabsence of S9, but no induction of chromosomal aberrations was noted, with orwithout S9. In contrast to the in vitro results, positive results wereobtained in an acute in vivo mouse bone marrow micronucleus assay withp,p'-dichlorodiphenyl sulfone administered by intraperitoneal injection threetimes over a dose range of 200 to 800 mg/kg. Conclusions. Under theconditions of these 2-year feed studies, there was no evidence of carcinogenic
activity of p,p'-dichlorodiphenyl sulfone in male F344/N rats exposed to 10,30, or 100 ppm or in female F344/N rats exposed to 30, 100, or 300 ppm. There
was no evidence of carcinogenic activity of p,p'-dichlorodiphenyl sulfone inmale or female B6C3F1 mice exposed to 30, 100, or 300 ppm. Exposure top,p'-dichlorodiphenyl sulfone for 2 years caused increased incidences ofnonneoplastic lesions of the liver in male and female rats and mice.
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
ANIMAL; acute toxicity; subacute toxicity; chronic
toxicity; carcinogenicity; genetic toxicity;
toxicokinetics; liver; dose response; textile industry;
pesticides
REGISTRY NUMBER:
80-07-9January 2022

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ACCESSION NUMBER:
DOCUMENT NUMBER:
TITLE:CORPORATE SOURCE:
ORDER NUMBER:
SOURCE:
FILE SEGMENT:ENTRY DATE:

2002:612111 TOXCENTERTSCATS-452426
MUTAGENICITY EVALUATION OF HEXAMETHYLDISILOXANE. FINALREPORT.
LITTON BIONETICS INC
NTIS/OTS0572722
EPA/OTS; Doc #86940001687.
TSCATSEntered STN: Dec 2002
Last Updated on STN: Dec 2002

ABSTRACT:Hexamethyldisiloxane did not produce responses in the L5178Y mouse lymphoma
cells which indicated consistent genetic activity. Several scattered increases
appeared to be the result of spurious fluctuations and cytotoxicity. The only
evidence of a genotoxic response was the induction of chromosome aberrations
under non-activation test conditions. These data can be considered evidence
for weak clastogenic activity.
CLASSIFICATION CODE: TSCA Sect. 8D Rec 04/28/94
SUPPLEMENTARY TERMS: Miscellaneous Descriptors
INDUS HLTH FOUNDATION INC; HEXAMETHYLDISILOXANE (CAS#107-46-0); HEALTH EFFECTS; GENOTOXICITY; GENE MUTATIONS;MAMMALS; MICE; IN VITROREGISTRY NUMBER:
107-46-0
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197
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6
USE CSTA protein, human/CN********** END **********

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824
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1
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Therapeutic Uses/CT
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3476
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Dermatologic Agents/CT
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Chemical Actions and Uses/CT
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BT4
Pharmacologic Actions/CT
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1861
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6182
BT1
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D27.505.954.444.695./CT
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D27.720.799.763.764./CT
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an INDEX MEDICUS major descriptor
NOTE Chemical or physical agents that protect theskin from sunburn and erythema by absorbing or
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INDX D25-26 qualif
AQ
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HNTE 72(66)MHTH NLM (1966)
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1
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55
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102
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15
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86
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BT1
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MH
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DC
an INDEX MEDICUS major descriptor
NOTE Chemical or physical agents that protect theskin from sunburn and erythema by absorbing or
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INDX D25-26 qualif
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HNTE 72(66)MHTH NLM (1966)
E24
UF
Agents, Sunscreening/MN
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UF
Sunscreens/MN
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RT
Sun Protection Factor/MN********** END **********EXPAND in /ORGN Thesaurus=> E RODENTIA+ALL/ORGN
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E8
E9
E10
E11
E12
E13
E14
E15
E16
E17
E18
E19
E20
E21
E22

0
0
13699451293434
1291289
1219228449350
2699
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39
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21967
208
19987
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5
20
6

BT6 Super Taxa/ORGN
BT5 Super Taxa Terms/ORGN
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E23
7
E24
14
E25
22
E26
32
E27
7
E28
42
E29
4
E30
29
E31
417448
E32
14
E33
5
E34
0
E35
6
E36
3
E37
367
E38
13
E39
7
E40
2
E41
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E42
449350********** END **********

NT1
NT1
NT1
NT1
NT1
NT1
NT1
NT1
NT1
NT1
NT1
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NT1
NT1
NT1
NT1
RT

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Heteromyidae/ORGN
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0
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NOTE Studies of the breeding, feeding, housing, andmanagement of animals used to produce consumer
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NOTE For studies of disease and health care ofdomesticated or zoo animals, see Veterinary
Medicine. For studies of fish rearing, see
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E5
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