PS (Pharmaceutical Substances)
SubjectCoverage• Marketed Active Pharmaceutical Ingredients• Preparation Methods for Pharmaceutical Substances

File Type

Substance (not structure searchable)

Features

Thesaurus

NoneAlerts (SDIs)

Not available

CAS RegistryNumber® IdentifiersKeep & Share

SLART



RecordContent• Records contain essential information, trade data and preparation methods for active
pharmaceutical ingredients.
• For indexed pharmaceutical substances ATC, therapeutic use, chemical name,molecular formula, CAS Registry Number, EINECS Number, lethal dose, information
on derivatives, and substance class are given.
• Also provided are formulations, trade names and vendors, and an overview of theintermediates in the compound’s preparation.
• Reaction schemes for industrial synthesis, can be displayed as images.

File Size• Pharmaceutical ingredients launched from 1957 – to date
• 2807 pharmaceutical substances

Coverage1957 – to date

Updates

Irregularly

Language

English

Database
Producer

Georg Thieme Verlag
Thieme Chemistry
Rüdigerstrasse 1470469 Stuttgart
Germany
Phone: +49 711 8931-0
Email: marketing@thieme-chemistry.com
Copyright Holder

November 2022

2PSSources••••User Aids

• Online Helps (HELP DIRECTORY lists all help messages available)• STNGUIDECluster• BIOSCIENCE• CASRNS• PHARMACOLOGY• REACTIONSSTN Database Cluster information:
http://www.stn-international.com/en/customersupport/customersupport#cluster+%7C+subjects+%7C+features

November 2022

The U.S. Food and Drug Administration (FDA)
ATC Index from the WHO
Patents
Publications and databases in the field of organic chemistry3PS

Search and Display Field Codes
Fields that allow left truncation are indicated by an asterisk (*).

General Search Fields
Search Field NameBasic Index* (contains single
words from the chemical name(CN), definition (DEF) and CAS
registry number (RN) fields)* (1)SearchCodeNoneor/BIAccession Number
Chemical Name (1)/AN/CN

Chemical Name Segment
Definition (Compound Class)
Entry Date (2)INCHI Key (2)

/CNS
/DEF
/ED (or /UP)
/INCHI

Molecular Formula
Molecular Weight (2)/MF/MW(or /FW)/RN

CAS Registry Number

Display
Codes

Search Examples
S CODEINE/BI
S 60-00-4
S C10H11NO3S

CN, DEF;RN

S 10006/AN
S BETAMETHASONE ACETATE/CNS DIAZEPAM/CNS KETOPROFEN/CNSS TYROSINES/DEF
S AUG 2022/ED
S MBOMYENWWXQSNW-AWEZNQCLSAN/INCHIS C22H30N6O4S/MF
S MW>500

ANCN

S 40054-69-1/RN

RNCNSDEFED
INCHIMFMW(1) CN search field contains Generic Names, Synonyms, Systematic Names, and Trade Names.
(2) Numeric search field which may be searched with numeric operators or ranges.

November 2022

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DISPLAY and PRINT Formats
Any combination of codes may be used to display or print answers. Multiple codes must be separated byspaces or commas, e.g., D L1 1-5 FRM, TRD. The fields are displayed or printed in the order requested. Hitterm highlighting is available in all searchable fields.
Highlighting must be ON during SEARCH to use the HIT, and OCC formats.
Format
ANCC
CN
DEF
DRV
ED (UP)
EIN
FRM
GI (PRE)
INCHI
INT
LD50
MF
MW (FW)
RE
RN
THER
TRD
ALL
IALL
IDE
TRIAL (TRI, SAMPLE,SAM, FREE)
SCAN (1)
HIT
KWIC
OCC

Content
Accession Number
Classification Code (ATC Code)
Chemical Name
Definition (Compound Class)
Derivatives (comprises CN.DRV, EIN.DRV, LD50.DRV, MF.DRV,RN.DRV)
Entry Date
EINECS NumberFormulation
Graphical Image (Preparation(s))
INCHI KeyIntermediate(s) Table
Lethal Dose
Molecular Formula
Molecular Weight
Reference
CAS Registry Number
Therapeutic Use
Trade TableDISPLAY L2 1-10 AN
D CC
DISPLAY CN 1-5
D DEF
D DRV

AN, ED, CN, CC, THER, RN, MF, INCHI, MW, EIN, LD50, DEF,DRV, TRD, GI (PRE), INT, RE
ALL, indented with text labels
AN, ED, CN, CC, THER, RN, MF, INCHI, MW, EIN, DEF (default)
AN, CN, CC

D ALL

CN, CC (random display, no answer number)

D SCANHit term(s) and field(s)Up to 50 words before and after hit term(s) (KeyWord-In-Context)
Number of occurrences of hit term(s) and field(s) in which they occur

D HIT
D KWICD OCC(1) SCAN must be specified on the command line, i.e., D SCAN or DISPLAY SCAN.

November 2022

Examples

D ED
D EIN
D FRM
D GI L9 1-5
D INCHID INTDIS LD50
D MF
D MW
D REF L5 1
DIS RN
D THER
D TRD

D IALL
D IDE
D TRIAL

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SELECT, ANALYZE, and SORT Fields
The SELECT command is used to create E-numbers containing terms taken from the specified field in ananswer set.
The ANALYZE command is used to create an L-number containing terms taken from the specified field in ananswer set.
The SORT command is used to rearrange the search results in either alphabetic or numeric order of thespecified field(s).

Field Name
Chemical Name
Definition (Compound Class)Molecular Weight
CAS Registry Number

Field CodeCNDEF
MW (FW)RN

ANALYZE/SELECT (1)YYNY

SORTNNYN(1) Hit may be used to restrict extracted terms to terms that match the search expression used to create the answer set, e.g., SEL HITCN.

Sample Record
DISPLAY IALLACCESSION NUMBER:
ENTRY DATE:CHEMICAL NAME:

CLASSIFICATION CODE:
THERAPEUTICS:
CAS REGISTRY NUMBER:
MOLECULAR FORMULA:INCHI CODE:
MOLECULAR WEIGHT:
FORMULATION:
DEFINITION:DERIVATIVES:

20190
PS
Entered STN: 24 Aug 2022
Last updated on STN: 24 Aug 2022
GENERIC: Belumosudil
SYNONYM: KD025, ME-3208
SYSTEMATIC: 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin2-yl)phenoxy)-N-(propan-2-yl)acetamide
L04AA48
chronic graft versus host disease, rho-kinase 2inhibitor
911417-87-3
C26H24N6O2GKHIVNAUVKXIIY-UHFFFAOYSA-N
452.52tbl. 200 mg
Indazoles; Quinazolines; Acetamides
CN.DRV
Mesylate
LSF.DRVC26H24N6O2.CH3SO3H
MW.DRV
548.61
RN.DRV
2109704-99-4

TRD
Trade Data
Launch |Trade Name|Company Name (Manufacturer)Country||=======+==========+============================
USA|Rezurock |Kadmon Pharmaceuticals, 2021||||
PREPARATIONS:
November 2022

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INT
Intermediate(s) in Substance Preparation
CAS RN|Molecular Formula|Chemical Name=============+=================+================================================
88-68-6|C7H8N2O|Anthranilamide
1711-05-3|C8H7ClO2|m-Anisoyl chloride
330657-87-9 |C15H14N2O3|N-(2-carbamoylphenyl)-3-methoxybenzamide
November 2022

7PS
56071-04-6
371947-93-2
129488-10-4
5292-43-3
75-31-0|C15H12N2O2|C16H12N2O3||C12H15N3O2|C6H11BrO2|C3H9N|2-(3-methoxyphenyl)quinazolin-4-one|3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl aceta|te|tert-butyl 5-amino-indazole-1-carboxylate|tert-butyl bromoacetate|Isopropylamine

REFERENCE:WO 2006 105081 (Surface Logix; 05.10.2005; USA-prior.
25.05.2005).
US 8 357 693 (Surface Logix; 22.01.2013; USA-prior.
25.05.2005).
WO 2014 055996 (Kadmon Corp.; 10.04.2014; USA-prior.
05.10.2012).
US 9 815 820 (Kadmon Corp.; 14.11.2017; USA-prior.
05.10.2012).
US 10 183 931 (Kadmon Corp.; 22.01.2019; USA-prior.
05.10.2012).
US 10 696 660 (Kadmon Corp.; 30.06.2020; USA-prior.
05.10.2012).

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November 2022