56789:;<= 56789:.=   The development of novel drug database describing molecularpharmacological knowledge
Ito Etsuko Kaneko Shuji
Graduate School of Pharmaceutical Sciences, Kyoto University
We have developed a novel drug database describing sites and modes of action from molecular pharmacoloical point ofview. About 18,000 drug names were collected from JAPIC, JAN, ATC, KEGG and MeSH databases and rearranged to asynonym table listing 2,800 active chemical compounds. The sites of action were assigned to one or few target molecules
described with MeSH descriptors and RefSeq genes. The mode of action for each interaction was described with simle
descriptors, such as 'inhibition' and 'activation'. As a result, the modes of drug ation were assigned to approximately 70% ofactive compounds to 500 target molecules. The molecular pharmacology database will be of useful for constructing medical
ontology.

Keywords: pharmacological action, ligandp, ontology, drug name !"#$
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