NO. DEFC0519

AQUALYTE GRO-A

Date of issue : 4 Jun. 2020
Date of revision : 30 Jun. 2023
Safety Data Sheet

1.

Product and company identification
Product name

: AQUALYTE GRO-A

Part No.

: D311173-A02, D311173-A12

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f2@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical and chemical hazard
Flammable liquids ：Category 2
Human health hazard
Acute toxicity (oral)：Category 4
Acute toxicity (inhalation)：Category 3
Skin corrosion/irritation：Category 2
Serious eye damage/eye irritation：Category 1
Skin sensitization ：Category 1
Carcinogenicity：Category 2

Reproductive toxicity：Category 1BSpecific target organ toxicity (single exposure)：Category 1, Category 2, Category 3 （anesthetic action）
Specific target organ toxicity (repeated exposure)：Category 1, Category 2
Environmental hazard
Aquatic acute：Category 2－ 1/13 －NO. DEFC0519

AQUALYTE GRO-A

Aquatic chronic：Category 2

Pictograms or symbols

Signal word

：Danger

Hazard statements：Highly flammable liquid and vapor
Harmful if swallowed
Toxic if inhaled
Causes skin irritation
Causes serious eye damage
May cause an allergic skin reaction
Suspected of causing cancer
May damage fertility or the unborn childCauses damage to organs (central nervous system, visualorgans, systemic toxicity, liver)May cause damage to organs (kidney, respiratory organs)
May cause drowsiness and dizziness
Causes damage to organs (central nervous system, visualorgans, respiratory organs) through prolonged or repeatedexposure
May cause damage to organs (blood, kidney, liver, thyroid
gland) through prolonged or repeated exposure
Toxic to aquatic life
Toxic to aquatic life with long lasting effects

Precautionary statements
Prevention：Do not handle until all safety precautions have been read andunderstood.
Keep away from ignition sources such as heat, sparks, or open
flame.
Keep containers tightly closed.
Ground container and receiving equipment in case of transportand stirring.
Use explosion-proof apparatus.
Use only non-sparking tools.
Do not breathe dust, mist, and vapor.
Use only in a well-ventilated area.
Avoid release to the environment.
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AQUALYTE GRO-A

Do not eat, drink or smoke when using this product.
Contaminated work clothing should not be allowed out of theworkplace.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.
Wash protective equipment thoroughly after use.
Wash hands thoroughly after handling.
Response：If inhaled : Remove victim to fresh air and keep at rest in aposition comfortable for breathing. Immediately get medical
treatment.
If swallowed: Rinse mouth. Get medical treatment if you feelunwell.
If in eyes : Rinse continuously with water for several minutes.
Get medical treatment.
If on skin : Remove contaminated clothing and the substance.
Immediately get medical treatment.
If exposed, get medical treatment.
Get medical treatment, if you feel unwell.
Collect leakage

Storage：Tightly container closed and store in a well-ventilated area.
Store locked up.

Disposal：Dispose of contents and containers appropriately in accordancewith related regulations.

3.

Composition/Information on ingredients
Distinction of substance or mixture：Mixture
Chemical nameConcentration

Formula(%)

TSCA

EC-No.

CAS RN

Methanol

51

CH3OH

Listed200-659-6

67-56-1

Hexyl alcohol22

CH3(CH2)5OH

Listed203-852-3

111-27-3

Imidazole

1-5

C 3H 4N 2

Listed206-019-2

288-32-4

2,2'-Iminodiethanol

8-15(HOCH2CH2)2NH

Listed203-868-0

111-42-2

Sulfur dioxide

4-8

SO2

Listed231-195-2

7446-09-5

Iodine1-5

I2

Listed231-442-4

7553-56-2

4.

First aid measures－ 3/13 －NO. DEFC0519

AQUALYTE GRO-A

Inhalation：Remove the victim to fresh air, and make him blow his noseand gargle.

Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. Get medical treatment.

Ingestion：Rinse mouth with water. Give the victim one or two glasses ofwater or milk. Do not induce vomiting. Get medical treatment
as soon as possible.

Anticipated acute and delayed symptoms：When the steam of the methanol is inhaled, the cough,headache, dizziness, losing breath, and the evil intention, etc.
might be caused. The symptom might appear delaying.
Protection for first aid person：Savers wear proper protective equipment like rubber gloves,
goggles.

5.

Fire fighting measures
Extinguishing media：Water, dry chemical powder, carbon dioxide, dry sand, alcohol
resistant foam

Prohibited extinguishing media：Foam extinguisher
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be
used for small fires. Alcohol-resistant foam extinguisher iseffective for a large scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures
Cautions for personnel：Wear proper equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind andevacuate people downwind. Remove all sources of ignition.
Keep away personnel except for authorized ones from spillage
area by stretching ropes..
－ 4/13 －NO. DEFC0519

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Cautions for environment：Attention should be given to avoid discharge of spilled productinto rivers and resulting environmental damage. When diluting
spill with large amounts of water, discharge of untreated waste
water into the environment must be avoided.
Methods and Equipment for Containment and Cleaning up
For containment：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush spillage area with copious amounts of water.

Prevention of second accident：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Engineering measures：Wear proper protective equipment to avoid contact with skinor inhalation of vapor. Fire is strictly prohibited.
Ventilate well at working places.
Prevent build-up of electrostatic charges (e.g. by grounding).
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Use in well-ventilated areas.
Cautions：Do not contact with oxidizing substances.

Storage
Adequate storage condition：Store in a dark, cool place and tightly closed.
Safety adequate container materials：Glass, fluorine resin, stainless steel
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8.

Exposure control/Personal protection
Methanol

ACGIH TWA：200ppm
ACGIH STEL：250ppm

Hexyl alcohol

Not established

Imidazole

Not established2,2'-Iminodiethanol

ACGIH TWA：1mg/m3

Sulfur dioxide

ACGIH STEL：0.25ppm

IodineACGIH TWA：0.01ppm－ 5/13 －NO. DEFC0519

AQUALYTE GRO-A

ACGIH STEL：0.1ppm
Engineering measures：Use with an enclosed system or a local exhaust ventilation.
Protective equipment
Respiration protective equipment：If necessary, wear chemical cartridge respirator with anorganic vapor cartage
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles
Skin and body protective equipment：Protective clothing, protective boots9.

Physical and chemical properties
Appearance：Liquid

Color：Yellow

Odor：Aromatic odorpH

；No data available

Melting point；No data available

Freezing point：No data available

Boiling point：No data available

Flash point：12℃(as methanol)

Auto ignition temperature：470℃(as methanol)
Decomposition temperature：No data available
Flammability：Flammable

Vapor pressure：No data available

Density：No data available

Relative gas density ：No data available
Solubility：

Partition coefficient n-octanol/water (log Pow)
：No data available
Explosive limits (vol %)：No data available
Viscosity, kinematic：No data available－ 6/13 －NO. DEFC0519

AQUALYTE GRO-A

Particle characteristics：No data available

10. Stability and reactivity
Reactivity：React with oxidizing substances.

Chemical Stability：Stable under normal conditions.

Possibility of hazardous reactions：React with oxidizing substances.
Conditions to avoid：Light, heat

Incompatible materials ：Oxidizing substances
Hazardous decomposition products：Carbon monoxide, nitrogen oxides, sulfur oxides, iodine,hydrogen iodide

11. Toxicological information
Acute toxicity (oral) ：Harmful if swallowed(as methanol)
rat LD50=6200mg/kg
As far as animal studies are concerned, methanol is considered
to be out of category in acute toxicity (oral). However, as
methanol shows strong toxicity in primates, the product wasclassified into category 4.
(as imidazole)
rat LD50=960-970mg/kg(as iodine)rat LD50=315mg/kg
Acute toxicity (dermal)：No classification
Acute toxicity (inhalation)：Toxic if inhaled(vapor)(as iodine)rat LC50=35ppm/4H
No classification (dust, mist)
Skin corrosion/irritation：Causes skin irritation
In the rabbit test, 4-hour application of 0.5 mL of 80%
imidazole as paste form with water to rabbit skin, severe
erythema appeared after one night and lasted until day 8 at
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AQUALYTE GRO-A

the end of observation period, and mild necrosis appeared after
one night and necrosis extending to all layers waspathologically observed at the end of observation period.
The product was classified into category 2 based on its
content.
Serious eye damage/eye irritation：Causes serious eye damage
In the test which is applied 0.1g of undiluted
2,2'-iminodiethanol to the eyes of rabbits, severe irritation wasobserved in the cornea, iris and conjunctiva. Eye irritation index(maximum value is 110, corresponding to AOI) is 50-56, until
24 to 72 hours, in addition, there is 41-45, until 96 to 168
hours. It is considered that pH of this substance is 11 at 0.1N
aqueous solution, the product was classified into category 1..
Respiratory sensitization：Classification not possible
Skin sensitization：May cause an allergic skin reaction
Iodine is listed in the 2nd skin group of the sensitization
substance of Recommendation of Acceptable Concentration ofJapanese Society for Occupational Health. Thus, this productwas classified into category 1.

Germ cell mutagenicity：Classification not possible
Carcinogenicity：Suspected of causing cancer
IARC classifies 2,2'-iminodiethanol as group 2B (possibly
carcinogenic to humans). Thus, the product was classified into
category 2.

Reproductive toxicity：May damage fertility or the unborn child
In inhalation exposure tests of methanol in pregnant mice duringorganogenetic period, fetal resorption, exencephaly etc. wereobserved. In another inhalation or oral exposure test, similar
results including cleft palate were observed. Based on evidence
from animal studies, it is considered that methanol may cause
adverse effects on human reproduction if the exposure amountis sufficient. Thus, the product was classified into category 1B.
Specific target organ toxicity (single exposure)：Cause damage to organs (central nervous system, visual organ,
systematic toxicity, liver)－ 8/13 －NO. DEFC0519

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May cause damage to organs (kidney, respiratory organs)
May cause drowsiness and dizziness
Methanol : The symptoms of acute poisoning from thesubstance include CNS-depression. Formate accumulates in the
blood during a latency period which leads to metabolic acidosis,
visual impairment or even total blindness, headaches, dizziness,
nausea, vomiting, Kussmaul breathing and coma. In some cases
death is the final outcome. Further, CNS disorders, especiallyparkinsonism-like extrapyramidal symptoms were reported.
Morphological changes, necrosis in the white substance of thebrain were demonstrated. Based on the human information, thesubstance was classified into category 1 (central nervous
system). Additionally, the eye was regarded as a target organ
since visual impairment is a characteristic effect. Additionally,systemic toxicity is regarded as a target organ based on thereports of headache, nausea, vomiting, tachypnea and coma as
signs of metabolic acidosis. The effects of single exposures byinhalation include narcosis. As an acute toxicity in humans, anarcotic effect results from central nervous system depression.
Based on the data, the substance was classified into category
3 (anesthetic action).
2,2'-Iminodiethanol : By oral administration to rats, appearedminor failure in liver parenchymal cells at 200-1600mg/kg,
large fat droplets and localized cytoplasmic degeneration in liver
cells at 1600 mg/kg, the tubules cell necrosis of kidney at
400mg/kg or more, increase of urea in serum, SGOT, and LDH
were observed. From above information, effects at dosage of
guidance value of category 1 for the liver, and guidance valueof category 2 for kidneys were reported, it was classified into
category 1 (liver), category 2 (kidney). In addition, in the caseof deaths, by the inhalation exposure 1476 ppm (6.35mg/L)(4 hours converted value: 2.778mg/L) for 105 minutes,
lethargy, incoordination, characterized by gasps and rale, slow
breathing as a characteristic findings were appeared to rats.
As a characteristic findings, an increase in the lowering of theheart rate, significant respiratory distress, systolic bloodpressure increase were observed. Since there is the descriptionthat the main histopathological findings was a pulmonary edema,
exposure concentration was corresponds to the guidance value－ 9/13 －NO. DEFC0519

AQUALYTE GRO-A

category 2, it was classified into category 2 (respiratoryorgans).
The product was classified into category 1 (central nervous
system, visual organs, systemic toxicity, liver), category 2(kidney, respirator organs), and category 3 (anesthetic action)
based on each content.
Specific target organ toxicity (repeated exposure)：Cause damage to organs (central nervous system, visualorgans, respiratory organs) through prolonged or repeatedexposure
May cause damage to organs (blood, kidneys, liver, thyroid
gland) through prolonged or repeated exposure
2,2'-Iminodiethanol : In a study for 3 months inhalation
exposure(mist) to rats, the larynx of squamous metaplasia wereobserved at dosage of 0.015 mg/L/6h or more, severe
inflammation was observed in pharynx and airway at dosage of
0.15 mg/L/6h or more. Since dosage is within guidance valueof category 1, it was classified into category 1(respiratoryorgans). In addition, in 49- days drinking water administration
test of 42-550 mg/kg/day to rats, normocytic anemia,
destruction of renal tubular epithelial cells, extensions andvarious early necrotic changes in the distal tubule, which was
accompanied by a glass cylinder, and various early necroticchanges, degenerative changes of the early characterized byloss of cloudy swelling and basic of liver cells were observedat dosage of 155 mg/kg/day (90 days corresponding value:
84.3 mg/kg/day) or more. In three months drinking water
administered test the 25-436 mg/kg/day in rats, based on
the report that dose-dependent generation of microcytic
anemia, kidney disease, renal tubular necrosis, and incidence ordegree of enhancement of mineralized were observed, sinceeffect dosage was corresponding to the guidance value ofcategory 2, it was classified into category 2(blood, kidney,
liver).
Methanol : Based on a report that the most noted healthconsequence of longer-term exposure to lower levels of
methanol is a broad range of ocular effects, and that cases ofchronic poisoning from occupational exposure to methanol weremanifested by bilateral blindness, it was classified into category－ 10/13 －NO. DEFC0519

AQUALYTE GRO-A

1 (visual organs). Additionally, based on the report that casesof chronic poisoning from repeated exposure to methanol vapor
are manifested by headache, giddiness, insomnia, and gastricdisturbances, it was classified into category 1 (central nervous
system).
Iodine : Human studies have shown that chronic overdose ofiodine may cause hyperthyroidism (at doses above 8
mg/kg/day (about 560 mg/day)) or hypothyroidism (at doses
below 8 mg/kg/day). Thus, it was classified into category 1(thyroid gland).
The product was classified into category 1 (central nervous
system, visual organs, respiratory organs), and category 2(blood, kidney, liver, thyroid gland) based on each content.
Aspiration hazard：Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute：Toxic to aquatic life
(as iodine)
Daphnia magana LC50=0.16mg/L/48H(as 2,2'-iminodiethanol)
Daphnia pulex LC50=2.15mg/L/48H

Aquatic chronic：Toxic to aquatic life with long lasting effects

Persistence and degradability：(as methanol) Readily biodegradable BOD：92%
Bioaccumulative potential：(as methanol) Low bioconcentration log Pow：-0.82
Mobility in soil：(as methanol) High mobility Koc：2.75

Hazardous to the ozone layer：Classification not possible

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Containers：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

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14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)：1992

Proper Shipping Name (IMDG)：FLAMMABLE LIQUID, TOXIC, N.O.S.(Methanol, Hexyl alcohol, Solution)
Packing group (IMDG)：ⅡTransport hazard class(es) (IMDG)：3（6.1）
Air transport(IATA)
UN-No. (IATA)：1992

Proper Shipping Name (IATA)：Flammable liquid,toxic, n.o.s.(Methanol, Hexyl alcohol, Solution)
Packing group (IATA)：Ⅱ
Transport hazard class(es) (IATA)：3（6.1）Marine pollutant：Applicable

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category ：Y
MFAG-No

：131

15. Regulatory information
Regulatory information with regard to this substance in yourcountry or region should be examined by your own
responsibility.

16. Other information
References
1) Company data on file2) NITE Chemical Risk Information Platform (NITE CHRIP), National Institute ofTechnology and Evaluation.
＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,－ 12/13 －NO. DEFC0519

AQUALYTE GRO-A

and it does not represent a guarantee the properties of the product. The Safety Data Sheet(SDS) is
prepared based on JIS Z7253.

－ 13/13 －