2004 INTERNATIONAL CONFERENCE ON POLYAMINES:FUNCITONS AND CLINICAL APPLICATION
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PROGRAM―

November 28, Sunday
15:00 - 19:00

Registration

17:30 - 19:00

Opening lecture[Chairperson: Igarashi, K. (Japan)]
17:30 - 18:15[01] Pegg, A. E. (Pennsylvania State University, USA)
Synthesis and function of spermidine andspermine

18:15 - 19:00[02] Oshima, T. (Tokyo University of Pharmacy andLife Science, Japan)
Polyamines in life at around the boilingtemperature of water

19:00 - 21:00

Reception

November 29, Monday
8:45 - 12:30

Biosynthesis and its regulation[Chairperson: Phillips, M. A. (USA), Matsufuji, S.
(Japan)]8:45 - 9:15

[03] Phillips, M. A. (Univerisity of Texas, USA)
Chlorella virus PBCV-1 encodes an unusualarginine decarboxylase that is a close homolog ofeukaryotic ornithine decarboxylases

9:15 - 9:45

[04] Persson, L. (Lund University, Sweden)
Rapid turnover of Crithidia fasciculata ODC andAdoMetDC

9:45 - 10:15[05] Yamaguchi, Y. (Tohoku University, Japan)
Existence of counterpart of mammalian ODC
antizyme in prokaryote

10:15 - 10:45[06] Matsufuji, S. (Jikei University School of Medicine,Japan)
Distribution of antizyme 1 and 2

10:45 - 11:00
11:00 - 11:30[Coffee break][07] Kahana, C. (Weizmann Institute of Science,Israel)Degradation of antizyme-inhibitor, an ornithine
decarboxylase homologous protein, isubiquitin-dependent and is inhibited by antizyme
11:30 - 12:00[08] Coffino, P. (University of California, SanFrancisco, USA)
Recognition and degradation of ornithine
decarboxylase by the proteasome

12:00 - 12:30[09] Hackert, M. (University of Texas, USA)
Towards understanding the structures ofantizyme and its complexes

15:00 - 17:00

Oral presentation for posters (P01-P23) <titles>

19:00 - 21:30

Polyamine contents and their regulation[Chairperson: Janne, J. (Finland), Kashiwagi, K.
(Japan)]
19:00 - 19:30[10] Casero, R. A. (Johns Hopkins University Schoolof Medicine, USA)
Polyamine catabolism: implications for drug
response, cell death, and disease etiology

19:30 - 20:00[11] Janne, J. (University of Kuopio, Finland)
Alternative splicing-associated regulation ofspermidine/spermine N1-acetyltransferase gene
expression by polyamine analogues

20:00 - 20:30[12] Kashiwagi, K. (Chiba University, Japan)
Polyamine transport systems in Saccharomyces

cerevisiae
20:30 - 21:00[13] Belting, M. (Lund University, Sweden)
Uptake of polyamines and polybasic peptides via
proteoglycans: implications for tumor growth andgene delivery

21:00 - 21:30[14] Mitchell, J. L. A. (Northern Illinois University,USA)
Feedback regulation of polyamine transport andits implications in the use of polyamine analogs
as chemotherapeutic agents

November 30, Tuesday
8:45 - 12:30

Functions of polyamines in cell growth anddifferentiation[Chairperson: Persson, L. (Sweden), Shirahata, A.
(Japan)]8:45 - 9:15

[15] Algranati, I. D. (University of Buenos Aires,Argentina)

Regulation of foreign ODC and ADC genes
expression in Trypanosoma cruzi
9:15 - 9:45

[16] Madhubala, R. (Jawaharlal Nehru University,India)
Linking polyamine biosynthetic pathway and drug
resistance in Leishmania donovani

9:45 - 10:15[17] Igarashi, K. (Chiba University, Japan)
A unifying model for the role of polyamines inbacterial cell growth: the polyamine modulon

10:15 - 10:45[18] Atkins, J. F. (University of Utah, USA)Comparative analysis of newly found antizyme
genes - identification of novel +1 frameshifting
RNA sequences

10:45 - 11:00
11:00 - 11:30[Coffee break][19] Kusano, T. (Tohoku University, Japan)
Spermine acts as a signaling molecule during
defence reaction against tobacco mosaic virus in
tobacco plants

11:30 - 12:00[20] Ikeguchi, Y. (Josai University, Japan)
Effect of polyamines on differentiation of murinechondrogenic cell line ATDC5

12:00 - 12:30[21] Ohkido, M. (Jikei University School of Medicine,Japan)
Heterozygous knockout of antizyme 1 enhances
tumorigenesis in Min mice

15:00 - 17:00

Oral presentation for posters (P24-P46) <titles>

19:00 - 21:30

Polyamine interaction with macromolecules[Chairperson: Park, M. H. (USA), Oshima, T. (Japan)]
19:00 - 19:30[22] Yokoyama, S. (University of Tokyo, Japan)
Crystal structure of elongation factor Pfrom Thermus thermophilus HB8

19:30 - 20:00[23] Park, M. H. (National Institutes of Health, USA)The post-translational formation of hypusine ineukaryotic translation initiation factor 5A (eIF5A)

20:00 - 20:30[24] Kawai, G. (Chiba Institute of Technology, Japan)
NMR analyses of interaction between polyamines
and RNA

20:30 - 21:00[25] Michael, A. J. (Institute of Food Research, UK)
Polyamines trigger a ribosomal switch between
two overlapping upstream open reading frames inplants

21:00 - 21:30[26] Murata, M. (Osaka University, Japan)
Rotational conformation of spermidine uponcomplexation with ATP investigated by solution
and solid-state NMR

December 1, Wednesday
8:45 - 12:00

Biological actions of polyamines[Chairperson: Heby, O. (Sweden), Kawakita, M.
(Japan)]8:45 - 9:15

[27] Bagni, N. (University of Bologna, Italy)Polyamines: application in agriculture andbiotechnology

9:15 - 9:45

[28] Fujihara, S. (National Agricultural ResearchCenter, Japan)
Polyamine metabolism of cyclamen plant infectedwith Fusarium oxysporum f.sp. cyclaminis

9:45 - 10:15[29] Heby, O. (Umea University, Sweden)
Embryonic stem (ES) cells and embryonalcarcinoma (EC) cells trigger the DNA damage
pathway in response to polyamine depletion

10:15 - 10:45[30] Kim, I. G. (Seoul National University, Korea)
Modulation of protein function by polyamination:
implication of protein polyamination in humandiseases

10:45 - 11:00
11:00 - 11:30[Coffee break][31] Serafini-Fracassini, D. (University of Bologna,Italy)
Polyamines conjugated to pollen proteins by anovel extracellular transglutaminase activity areinvolved in plant reproduction

11:30 - 12:00[32] Kojima, S. (RIKEN, Japan)
Potential role of polyamines as regulators ofblood vessel formation and hepatic apoptosis via
controling activity of tissue transglutaminase

13:30 - 17:30

Sightseeing

19:00 - 21:30

BanquetDecember 2, Thursday
8:45 - 12:00

Clinical aspects of polyamines[Chairperson: Gerner, E. W. (USA), Nagoshi, S.
(Japan)]8:45 - 9:15

[33] Alhonen, L. (University of Kuopio, Finland)
Activated polyamine catabolism in acutepancreatitis: polyamine analogues as potential
drugs to prevent mortality
9:15 - 9:45

[34] Kawakita, M. (Kogakuin University, Japan)
N1,N12-Diacetylspermine in urine: clinicalperformance as a tumor marker

9:45 - 10:15[35] Agostinelli, E. (University of Rome "LaSapienza", Italy)
Spermine oxidation products cause cytotoxicity
on cancer cells: anti-tumoral activities of nativeand immobilized serum amine oxidase afterinjection in mouse melanoma

10:15 - 10:45[36] Nilsson, J. A. (St. Jude Children's Research
Hospital, USA)
Targeting ornithine decarboxylase in
Myc-induced lymphomagenesis prevents tumor
formation

10:45 - 11:00
11:00 - 11:30[Coffee break][37] Wallace, H. M. (University of Aberdeen, UK)
Non-steroidal anti-inflammatory drugs,
polyamines and cancer chemoprevention

11:30 - 12:00

12:00 - 12:45[38] Gerner, E. W. (University of Arizona, USA)
Targeting polyamine metabolism forchemoprevention of epithelial cancers
Closing lecture[Chairperson: Ohsawa, N. (Japan)]

12:00 - 12:45[39] Cohen, S. S. (USA)On the international evolution of polyaminestudies

Posters
November 29, Monday, 14:30 - 17:30
November 30, Tuesday, 14:30 - 17:30[P01]

Ohnuma, M. (Tokyo University of Pharmacy and Life Science, Japan)
A new pathway for polyamine biosynthesis in an extreme thermophile, Thermus

thermophilus[P02]

Sanka, R. (Tokyo University of Pharmacy and Life Science, Japan)
Analysis of S-adenosylmethionine decarboxylase of Sulfolobus tokodaii[P03]

Chitose, A. (Tokyo University of Pharmacy and Life Science, Japan)
Characterization of speB (agmatinase) homolog of Thermus thermophilus

[P04]

Hasunuma, S. (Tokyo University of Pharmacy and Life Science, Japan)
Structure and function of polyamine spermidine synthase of Aquifex aeolicus[P05]

Ganbe, T. (Tokyo Institute of Technology, Japan)
Crystal structure of polyamine aminopropyltransferase from Thermusthermophilus[P06]

Fukuchi, J. (University of Chicago, USA)
Identification of TAF7 as a regulator of polyamine transport and MGBG-induced
apoptosis by gene-trap analysis[P07]

Uemura, T. (Chiba University, Japan)
Putrescine and spermidine uptake in Saccharomyces cerevisiae[P08]

Phanstiel IV, O. (University of Central Florida, USA)
Investigations of cell-selective drug delivery using the polyamine transporter[P09]

Murai, N. (Jikei University School of Medicine, Japan)
Subcellular localization and phosphorylation of antizyme 2[P10]

Murakami, Y. (Jikei University School of Medicine, Japan)
Possible function of antizyme inhibitor as a positive regulator of polyamines in
HTC cells[P11]

Jarvinen, A. (University of Kuopio, Finland)
Alpha-methylated polyamine analogs as substrates for the enzymes involved inthe polyamine catabolism[P12]

Cerrada-Gimenez, M. (University of Kuopio, Finland)
Depletion of putrescine enhances spermine production in two transgenic mouselines with activated polyamine catabolism[P13]

Niiranen, K. (University of Kuopio, Finland)
Characterization of spermidine/spermine N1-acetyltransferase gene-disrupted
mice

[P14]

Elliott, K. A. (Institute of Food Research, UK)
A genetic dissection of the roles of the ornithine and arginine routes toputrescine biosynthesis in the model plant Arabidopsis[P15]

Ohe, M. (Dokkyo University School of Medicine, Japan)
Analysis of polyamine metabolism in soybean seedlings using 15N-labelled
putrescine[P16]

Hyvonen, M. (University of Kuopio, Finland)
Regulation of alternative splicing of SSAT by polyamine analogues[P17]

Takao, K. (Josai University, Japan)
Assay method for spermidine/spermine-N1-acetyltransferase withdansylnorspermine as substrate[P18]

Suzuki, T. (Nagoya Univeristy, Japan)
A sensitive colorimetric assay for polyamines in erythrocytes using oat seedlingpolyamine oxidase[P19]

Shin, M. (Sojo University, Japan)
Localization of polyamines in rat testis: immunocytochemical study using aspecific monoclonal antibody[P20]

Terakado, J. (National Agricultural Research Center, Japan)
Involvement of polyamine in nodule regulation of soybean plant[P21]

Hamana, K. (Gunma University, Japan)
Widespread occurrence of homospermidine and canavalmine in mushrooms
belonging to the phyla Ascomycota and Bacidiomycota[P22]Pan, Y.-H. (National Yang-Ming University, Republic of China)
The critical roles of polyamines in regulating ColE7 production and restricting
ColE7 uptake in the colicin producing Escherichia coli

[P23]

Hanfrey, C. (Institute of Food Research, UK)
Translational state array analysis of Arabidopsis cell cultures: effect of growthstage and cellular polyamine levels[P24]

Inomata, E. (Chiba Institute of Technology, Japan)
Effects of the tetrakis(3-aminopropyl)ammonium on the conformation of tRNA

[P25]

Maruyoshi, K. (Osaka University, Japan)
Dynamic conformational change of deuterated spermidine upon complexation
with ATP[P26]

Shinozaki, H. (Tokyo University of Pharmacy and Life Science, Japan)
Effects of polyamines on protein synthesis of Thermus thermophilus[P27]

Moriya, T. (Tokyo University of Pharmacy and Life Science, Japan)
Effect of unusual branched polyamines for novel extreme thermophile, YMO81[P28]

Terui, Y. (Tokyo University of Pharmacy and Life Science, Japan)
Unusual branched polyamines produced by a novel extreme thermophile, YMO81[P29]

Nishimura, K. (Chiba University, Japan)
Independent roles of eIF5A and polyamines in cell proliferation[P30]

Childs, A. (University of Arizona, USA)The role of the polyamines and eIF5A in RNA processing[P31]

Ito, T. (Josai University, Japan)
Formation of polyamine-incorporated peptide during protein digestion[P32]

Lee, C. H. (Indiana University, USA)
Polyamines induce apoptosis in alveolar macrophages
during Pneumocystis pneumonia[P33]

Shiokawa, K. (Teikyo University, Japan)
Activation of caspase-9 and execution of the maternal program of apoptosis
in Xenopus late blastulae microinjected with mRNA for S-adenosylmethionine
decarboxylase

[P34]

Suzuki, T. (Chiba University Hospital, Japan)
Role of antizyme in the differentiation of vascular smooth muscle cells[P35]

Sugita, Y. (Josai University, Japan)
Effect of luminal polyamines on epithelial permeability of rat small intestine[P36]

Tomitori, H. (Fuence Co. Ltd., Japan)
Spermine oxidase and acrolein: novel biochemical markers for diagnosis of stroke[P37]

Dalla Vedova, L. (University of Rome "La Sapienza", Italy)
Amine oxidase and spermine cause cytotoxicity on wild-type and multidrug
resistant human cancer cells[P38]

Qu, N. (University of Arizona, USA)
Influence of a single nucleotide polymorphism (SNP) on E-box
protein-dependent expression of human ornithine decarboxylase[P39]

Basuroy, U. K. (University of Arizona, USA)
Oncogenic K-ras and Src regulate polyamine uptake in colon cancer cell lines[P40]

Nagoshi, S. (Saitama Medical School, Japan)
Polyamine depletion may prevent hepatocyte apoptosis through inhibitor ofapoptosis protein-1 (IAP-1) in mice

[P41]

Samejima, K. (Josai University, Japan)
Control of spermidine and spermine levels in rat tissues
by trans-4-methylcyclohexylamine[P42]

Merentie, M. (University of Kuopio, Finland)
The development of acute pancreatitis in transgenic rats with activatedpolyamine catabolism: the role of NF-kappaB and cytokines TNF-alpha, IL-1betaand IL-6

[P43]

Pirinen, E. (University of Kuopio, Finland)
Reduced white adipose tissue mass, increased basal metabolic rate and insulin
sensitivity are related to increased levels of putrescine and overexpression ofPGC-1alpha in transgenic mice overexpressing spermidine/spermine
N1-acetyltransferase[P44]

Pietila, M. (University of Kuopio, Finland)
Modulation of epidermal differentiation in transgenic mice overexpressing
spermidine/spermine N1-acetyltransferase by alterations in putrescine level[P45]

Tiwari, C. (Kalika Hospital and Research Centre (PVT.) Ltd., Nepal)
Growth status significantly affects the response of human lung cancer cells toantitumor polyamine-analogue exposure[P46]

Hirose, S. (Tokyo Institute of Technology, Japan)
Stabilization of collagen columns in gill lamellae by transglutaminase-mediatedcrosslinking