疫学・
予防

Question

PubMed検索式(("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Alcohol Drinking"[MeSH] OR ("alcohol
intake*"[TIAB] OR "alcohol use*"[TIAB] OR "alcohol consumed*"[TIAB] OR "alcoholic drink*"[TIAB] OR "alcohol beverage*"[TIAB] OR "alcoholism*"[TIAB] OR "alcohol
consumption*"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR "Risks"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR"retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast
neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB]
OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Alcohol Drinking"[MeSH] OR ("alcohol intake*"[TIAB] OR "alcohol use*"[TIAB] OR "alcohol
consumed*"[TIAB] OR "alcoholic drink*"[TIAB] OR "alcohol beverage*"[TIAB] OR "alcoholism*"[TIAB] OR "alcohol consumption*"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR

BQ1

アルコール飲料"Risks"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] ORの摂取は乳癌発"systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR症リスクを増加((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

させるか？

OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Alcohol Drinking"[MeSH] OR ("alcohol
intake*"[TIAB] OR "alcohol use*"[TIAB] OR "alcohol consumed*"[TIAB] OR "alcoholic drink*"[TIAB] OR "alcohol beverage*"[TIAB] OR "alcoholism*"[TIAB] OR "alcohol
consumption*"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR "Risks"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "casecomparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR"mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB])) AND ("Alcohol Drinking"[MeSH] OR ("alcohol intake*"[TIAB] OR "alcohol use*"[TIAB] OR "alcohol consumed*"[TIAB] OR "alcoholic drink*"[TIAB] OR "alcohol
beverage*"[TIAB] OR "alcoholism*"[TIAB] OR "alcohol consumption*"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR "Risks"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication]
AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as
Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Tobacco Smoke Pollution"[MeSH] OR

BQ2

喫煙（受動喫煙"Smoking"[MeSH] OR ("smoker"[TIAB] OR "tobacco user"[TIAB] OR "ever smoker"[TIAB] OR "smoking status"[TIAB] OR "smoking history"[TIAB] OR "smoking habit"[TIAB]) OR含む）は乳癌発("smoking devices"[MeSH] OR "heated tobacco"[TIAB] OR "heat not burn tobacco"[TIAB] OR "electronic cigarette"[TIAB] OR "vaping product*"[TIAB])) AND ("Risk"[MeSH] OR症リスクを増加"Risk"[TIAB] OR "Risks"[TIAB])) NOT (("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR

させるか"breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND("Tobacco Smoke Pollution"[MeSH] OR "Smoking"[MeSH] OR ("smoker"[TIAB] OR "tobacco user"[TIAB] OR "ever smoker"[TIAB] OR "smoking status"[TIAB] OR "smoking history"[TIAB]
OR "smoking habit"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR "Risks"[TIAB]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND (("Dairy Products"[MeSH] OR "Dietary
Fats"[MeSH] OR ("dairy product*"[TIAB] OR "butter*"[TIAB] OR "Ghee"[TIAB] OR "milk product*"[TIAB] OR "buttermilk*"[TIAB] OR "cheese*"[TIAB] OR "Kefir"[TIAB] OR"koumiss*"[TIAB] OR "yogurt*"[TIAB] OR "ice cream*"[TIAB] OR "margarine*"[TIAB] OR "milk protein*"[TIAB] OR "Whey"[TIAB] OR "lactobacill*"[TIAB] OR "acidophilus"[TIAB] OR "lactic
acid bacteri*"[TIAB])) NOT ("milk, human"[MeSH] OR "breast milk*"[TIAB] OR "milk breast"[TIAB] OR "human milk"[TIAB] OR "Breast Feeding"[TIAB] OR "Breast Feeding"[MeSH] OR"Lactation"[MeSH])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study
Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR"longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary
cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB])) AND (("Dairy Products"[MeSH] OR "Dietary Fats"[MeSH] OR ("dairy product*"[TIAB] OR "butter*"[TIAB] OR "Ghee"[TIAB] OR "milk product*"[TIAB] OR"buttermilk*"[TIAB] OR "cheese*"[TIAB] OR "Kefir"[TIAB] OR "koumiss*"[TIAB] OR "yogurt*"[TIAB] OR "ice cream*"[TIAB] OR "margarine*"[TIAB] OR "milk protein*"[TIAB] OR"Whey"[TIAB] OR "lactobacill*"[TIAB] OR "acidophilus"[TIAB] OR "lactic acid bacteri*"[TIAB])) NOT ("milk, human"[MeSH] OR "breast milk*"[TIAB] OR "milk breast"[TIAB] OR "human
乳製品の摂取は
BQ3

乳癌発症リスクを減少させるか？

milk"[TIAB] OR "Breast Feeding"[TIAB] OR "Breast Feeding"[MeSH] OR "Lactation"[MeSH])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR"ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("metaanalysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR ((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB]
OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary
carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND (("Dairy Products"[MeSH] OR "Dietary Fats"[MeSH] OR ("dairy product*"[TIAB] OR "butter*"[TIAB] OR "Ghee"[TIAB] OR "milkproduct*"[TIAB] OR "buttermilk*"[TIAB] OR "cheese*"[TIAB] OR "Kefir"[TIAB] OR "koumiss*"[TIAB] OR "yogurt*"[TIAB] OR "ice cream*"[TIAB] OR "margarine*"[TIAB] OR "milkprotein*"[TIAB] OR "Whey"[TIAB] OR "lactobacill*"[TIAB] OR "acidophilus"[TIAB] OR "lactic acid bacteri*"[TIAB])) NOT ("milk, human"[MeSH] OR "breast milk*"[TIAB] OR "milkbreast"[TIAB] OR "human milk"[TIAB] OR "Breast Feeding"[TIAB] OR "Breast Feeding"[MeSH] OR "Lactation"[MeSH])) AND 2016/01/01:2021/03/31[Date - Publication] AND("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "casecontrol*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast
cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary
carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND (("Dairy Products"[MeSH] OR "Dietary Fats"[MeSH] OR ("dairy product*"[TIAB] OR "butter*"[TIAB] OR "Ghee"[TIAB] OR "milkproduct*"[TIAB] OR "buttermilk*"[TIAB] OR "cheese*"[TIAB] OR "Kefir"[TIAB] OR "koumiss*"[TIAB] OR "yogurt*"[TIAB] OR "ice cream*"[TIAB] OR "margarine*"[TIAB] OR "milkprotein*"[TIAB] OR "Whey"[TIAB] OR "lactobacill*"[TIAB] OR "acidophilus"[TIAB] OR "lactic acid bacteri*"[TIAB])) NOT ("milk, human"[MeSH] OR "breast milk*"[TIAB] OR "milkbreast"[TIAB] OR "human milk"[TIAB] OR "Breast Feeding"[TIAB] OR "Breast Feeding"[MeSH] OR "Lactation"[MeSH])) AND 2016/01/01:2021/03/31[Date - Publication] AND("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH]
OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))

コーヒーの摂取
BQ4は乳癌発症リス
クを減少させるか？

("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Coffee"[Text Word] OR "Coffee"[TextWord]) AND 1000/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Soy Foods"[MeSH] OR "Isoflavones"[MeSH] OR "Equol"[MeSH] OR ("soybean*"[TIAB] OR "Soy"[TIAB] OR "isoflavone*"[TIAB] OR "Equol"[TIAB])) AND ((("Incidence"[MeSH] OR
大豆、イソフラ
BQ5ボンの摂取は乳癌発症リスクを減少させるか？

"Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR "Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR "neoplasms/epidemiology"[MeSH] OR "neoplasms/prevention andcontrol"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR "survival rate*"[TIAB] OR "death rate*"[TIAB] OR "Risk"[TIAB] OR "risks"[TIAB] OR "prevention*"[TIAB])) AND
1000/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])) NOT (("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR"breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary
carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND ("Soy Foods"[MeSH] OR "Isoflavones"[MeSH] OR ("soybean*"[TIAB] OR"Soy"[TIAB] OR "isoflavone*"[TIAB])) AND ((("Incidence"[MeSH] OR "Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR "Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR"neoplasms/epidemiology"[MeSH] OR "neoplasms/prevention and control"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR "survival rate*"[TIAB] OR "death rate*"[TIAB] OR"Risk"[TIAB] OR "risks"[TIAB] OR "prevention*"[TIAB])) AND 1000/01/01:2015/12/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]))(("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Dietary Supplements"[MeSH] OR "Functional Food"[MeSH] OR "Complementary Therapies"[MeSH] OR ("supplement*"[TIAB] OR "complementary therap*"[TIAB] OR "complementary
medicine*"[TIAB] OR "alternative therap*"[TIAB] OR "alternative medicine*"[TIAB])) AND ((("Incidence"[MeSH] OR "Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR"Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR "neoplasms/epidemiology"[MeSH] OR "neoplasms/prevention and control"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR"survival rate*"[TIAB] OR "death rate*"[TIAB] OR "Risk"[TIAB] OR "risks"[TIAB] OR "prevention*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR"ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative
stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("Breast Neoplasms"[MeSH] OR ("breast
tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR"breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND ("Dietary Supplements"[MeSH] OR"Functional Food"[MeSH] OR "Complementary Therapies"[MeSH] OR ("supplement*"[TIAB] OR "complementary therap*"[TIAB] OR "complementary medicine*"[TIAB] OR "alternative
therap*"[TIAB] OR "alternative medicine*"[TIAB])) AND ((("Incidence"[MeSH] OR "Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR "Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR"neoplasms/epidemiology"[MeSH] OR "neoplasms/prevention and control"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR "survival rate*"[TIAB] OR "death rate*"[TIAB] OR

BQ6

サプリメントの"Risk"[TIAB] OR "risks"[TIAB] OR "prevention*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst

服用は乳癌発症Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic

リスクを減少さreview"[Title]) NOT "Medline"[Filter]))) OR ((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary

せるか？

cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND ("Dietary Supplements"[MeSH] OR "Functional Food"[MeSH] OR "Complementary Therapies"[MeSH] OR("supplement*"[TIAB] OR "complementary therap*"[TIAB] OR "complementary medicine*"[TIAB] OR "alternative therap*"[TIAB] OR "alternative medicine*"[TIAB])) AND((("Incidence"[MeSH] OR "Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR "Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR "neoplasms/epidemiology"[MeSH] OR"neoplasms/prevention and control"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR "survival rate*"[TIAB] OR "death rate*"[TIAB] OR "Risk"[TIAB] OR "risks"[TIAB] OR"prevention*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR"random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("Breast
Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR"breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Dietary Supplements"[MeSH] OR "Functional Food"[MeSH] OR "Complementary Therapies"[MeSH] OR ("supplement*"[TIAB] OR "complementary therap*"[TIAB] OR "complementary
medicine*"[TIAB] OR "alternative therap*"[TIAB] OR "alternative medicine*"[TIAB])) AND ((("Incidence"[MeSH] OR "Mortality"[MeSH] OR "Mortality"[MeSH Subheading] OR"Risk"[MeSH]) AND "Neoplasms"[MeSH]) OR "neoplasms/epidemiology"[MeSH] OR "neoplasms/prevention and control"[MeSH] OR ("incidence*"[TIAB] OR "mortalit*"[TIAB] OR"survival rate*"[TIAB] OR "death rate*"[TIAB] OR "Risk"[TIAB] OR "risks"[TIAB] OR "prevention*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR

BQ7

肥満は乳癌発症"ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("metaBreast Neoplasms[MH] AND ("Obesity"[MH] OR "Body Mass Index"[MH]) AND ("Risk"[MH] OR "risk"[ALL]) AND ("Case-Control Studies"[MH] OR "Cohort Studies"[MH] OR

リスクと関連す"Comparative Study"[PT] OR "Meta-Analysis"[PT] OR "Practice Guideline"[PT] OR "Randomized Controlled trial"[PT] OR systematic[SB] OR "Clinical Trial"[PT]) AND ("Humans"[MH]るか？

AND (English[LA] OR Japanese[LA])) AND ("2016/1"[PDAT] : "2021/3"[PDAT])

(("breast neoplasms/prevention and control"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB]
OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR"mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("Motor Activity"[MeSH] OR "Sports"[MeSH] OR ("athletic*"[TIAB] OR "baseball*"[TIAB] OR "basketball*"[TIAB] OR"bicycling*"[TIAB] OR "boxing*"[TIAB] OR "fitness*"[TIAB] OR "diving*"[TIAB] OR "exercise*"[TIAB] OR "football*"[TIAB] OR "Golf"[TIAB] OR "gymnastic*"[TIAB] OR "hockey*"[TIAB] OR"jogging*"[TIAB] OR "martial art*"[TIAB] OR "mountaineering*"[TIAB] OR "physical activit*"[TIAB] OR "physical endurance*"[TIAB] OR "physical fitness*"[TIAB] OR "racquet
sport*"[TIAB] OR "running*"[TIAB] OR "skating*"[TIAB] OR "skiing*"[TIAB] OR "soccer*"[TIAB] OR "sport*"[TIAB] OR "swimming*"[TIAB] OR "tai ji*"[TIAB] OR "tennis*"[TIAB] OR"training*"[TIAB] OR "volleyball*"[TIAB] OR "walking*"[TIAB] OR "weight lifting*"[TIAB] OR "wrestling*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA]OR "ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative
stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("breast neoplasms/prevention andcontrol"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR"breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT"Medline"[Filter])) AND ("Motor Activity"[MeSH] OR "Sports"[MeSH] OR ("athletic*"[TIAB] OR "baseball*"[TIAB] OR "basketball*"[TIAB] OR "bicycling*"[TIAB] OR "boxing*"[TIAB] OR"fitness*"[TIAB] OR "diving*"[TIAB] OR "exercise*"[TIAB] OR "football*"[TIAB] OR "Golf"[TIAB] OR "gymnastic*"[TIAB] OR "hockey*"[TIAB] OR "jogging*"[TIAB] OR "martial art*"[TIAB]
運動は乳癌発症
BQ8

リスクを減少させるか？

OR "mountaineering*"[TIAB] OR "physical activit*"[TIAB] OR "physical endurance*"[TIAB] OR "physical fitness*"[TIAB] OR "racquet sport*"[TIAB] OR "running*"[TIAB] OR"skating*"[TIAB] OR "skiing*"[TIAB] OR "soccer*"[TIAB] OR "sport*"[TIAB] OR "swimming*"[TIAB] OR "tai ji*"[TIAB] OR "tennis*"[TIAB] OR "training*"[TIAB] OR "volleyball*"[TIAB] OR"walking*"[TIAB] OR "weight lifting*"[TIAB] OR "wrestling*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane
Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR"systematic review"[Title]) NOT "Medline"[Filter]))) OR ((("breast neoplasms/prevention and control"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR"breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast
carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("Motor Activity"[MeSH] OR "Sports"[MeSH] OR ("athletic*"[TIAB]
OR "baseball*"[TIAB] OR "basketball*"[TIAB] OR "bicycling*"[TIAB] OR "boxing*"[TIAB] OR "fitness*"[TIAB] OR "diving*"[TIAB] OR "exercise*"[TIAB] OR "football*"[TIAB] OR"Golf"[TIAB] OR "gymnastic*"[TIAB] OR "hockey*"[TIAB] OR "jogging*"[TIAB] OR "martial art*"[TIAB] OR "mountaineering*"[TIAB] OR "physical activit*"[TIAB] OR "physicalendurance*"[TIAB] OR "physical fitness*"[TIAB] OR "racquet sport*"[TIAB] OR "running*"[TIAB] OR "skating*"[TIAB] OR "skiing*"[TIAB] OR "soccer*"[TIAB] OR "sport*"[TIAB] OR"swimming*"[TIAB] OR "tai ji*"[TIAB] OR "tennis*"[TIAB] OR "training*"[TIAB] OR "volleyball*"[TIAB] OR "walking*"[TIAB] OR "weight lifting*"[TIAB] OR "wrestling*"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical
trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("breast neoplasms/prevention and control"[MeSH]
OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND("Motor Activity"[MeSH] OR "Sports"[MeSH] OR ("athletic*"[TIAB] OR "baseball*"[TIAB] OR "basketball*"[TIAB] OR "bicycling*"[TIAB] OR "boxing*"[TIAB] OR "fitness*"[TIAB] OR"diving*"[TIAB] OR "exercise*"[TIAB] OR "football*"[TIAB] OR "Golf"[TIAB] OR "gymnastic*"[TIAB] OR "hockey*"[TIAB] OR "jogging*"[TIAB] OR "martial art*"[TIAB] OR((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

夜間勤務は乳癌
BQ9

発症リスクを増加させるか？

OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Circadian Rhythm"[MeSH] OR "Work Schedule Tolerance"[MeSH] OR "Shift Work Schedule"[MeSH] OR ("Circadian Rhythm"[TIAB] OR "night work*"[TIAB] OR "night shift"[TIAB] OR"shift work*"[TIAB])) AND ("Risk"[MeSH] OR "Risk"[Text Word])) NOT (("Breast Neoplasms"[MeSH] OR "Breast Cancer"[TIAB]) AND ("Circadian Rhythm"[MeSH] OR "Work Schedule
Tolerance"[MeSH] OR "night work"[TIAB] OR "night worker"[TIAB] OR "night workers"[TIAB] OR "night-shift work"[TIAB] OR "night-shift worker"[TIAB]) AND ("Risk"[MeSH] OR"Risk"[All Fields]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA])BQ10

乳癌発症リスク(("breast neoplasms/etiology"[MeSH] AND ("Socioeconomic Factors"[MeSH] OR "Psychology"[MeSH] OR "stress, physiological"[MeSH] OR "Personality"[MeSH] OR "Life Changeに関連する心理Events"[MeSH] OR "Psychosocial Functioning"[MeSH]) AND ("risk"[MeSH] OR "risk"[Text Word])) NOT ("breast neoplasms/etiology"[MeSH] AND ("Socioeconomic Factors"[MeSH] OR

社会的要因はあ"Psychology"[MeSH] OR "stress, physiological"[MeSH] OR "Personality"[MeSH] OR "Life Change Events"[MeSH]) AND ("risk"[MeSH] OR "risk"[All Fields]) AND

るか？

1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA])(((("breast neoplasms/etiology"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary
cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB]) OR"Radiation"[MeSH] OR ("electromagnetic radiation*"[TIAB] OR "electromagnetic wave*"[TIAB] OR "electromagnetic energ*"[TIAB] OR "radiation dos*"[TIAB]))) OR (("neoplasms,
radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB])) AND "Breast"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR"cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((((("breast
neoplasms/etiology"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary
cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB]) OR"Radiation"[MeSH] OR ("electromagnetic radiation*"[TIAB] OR "electromagnetic wave*"[TIAB] OR "electromagnetic energ*"[TIAB] OR "radiation dos*"[TIAB]))) OR (("neoplasms,
radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB])) AND "Breast"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND

BQ11

放射線被曝は乳("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH]

癌発症リスクをOR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR ((((("breast neoplasms/etiology"[MeSH] OR "breast

増加させるか？

neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB]) OR "Radiation"[MeSH] OR ("electromagnetic radiation*"[TIAB]
OR "electromagnetic wave*"[TIAB] OR "electromagnetic energ*"[TIAB] OR "radiation dos*"[TIAB]))) OR (("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB]
OR "radiation induced cancer*"[TIAB])) AND "Breast"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR"Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational
stud*"[TIAB])) NOT (((("breast neoplasms/etiology"[MeSH] OR "breast neoplasms/epidemiology"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast
cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary
carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiationinduced cancer*"[TIAB]) OR "Radiation"[MeSH] OR ("electromagnetic radiation*"[TIAB] OR "electromagnetic wave*"[TIAB] OR "electromagnetic energ*"[TIAB] OR "radiation
dos*"[TIAB]))) OR (("neoplasms, radiation induced"[MeSH] OR ("radiation induced neoplasm*"[TIAB] OR "radiation induced cancer*"[TIAB])) AND "Breast"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR"Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))

((("breast neoplasms/etiology"[MeSH Major Topic] OR "breast neoplasms/pathology"[MeSH Major Topic]) AND ("benign breast disease"[TIAB] OR ("breast"[TIAB] AND ("Neoplasm
Invasiveness"[MeSH] OR "Precancerous Conditions"[MeSH] OR "Hyperplasia"[MeSH] OR "Hyperplasia"[TIAB]))) AND ("Risk"[MeSH] OR "risk*"[TIAB]) AND ("Clinical Trial"[PT] OR

BQ12

良性乳腺疾患は"Cohort Studies"[MeSH] OR "Meta-Analysis"[PT] OR "practice guideline"[PT] OR "randomized controlled trial"[PT] OR "systematic"[Filter] OR "comparative study"[PT] OR "multicenter

乳癌発症リスクstudy"[PT])) NOT (("breast neoplasms/etiology"[MeSH Major Topic] OR "breast neoplasms/pathology"[MeSH Major Topic]) AND ("benign breast disease"[TIAB] OR ("breast"[TIAB] ANDを増加させる("Neoplasm Invasiveness"[MeSH] OR "Precancerous Conditions"[MeSH] OR "Hyperplasia"[MeSH] OR "Hyperplasia"[TIAB]))) AND ("Clinical Trial"[PT] OR "Cohort Studies"[MeSH] OR

か？

"Meta-Analysis"[PT] OR "practice guideline"[PT] OR "randomized controlled trial"[PT] OR "systematic"[Filter] OR "comparative study"[PT] OR "multicenter study"[PT]) AND"Humans"[MeSH] AND ("English"[LA] OR "Japanese"[LA]) AND 1000/01/01:2015/12/31[Date - Publication])) AND 0001/01/01:2021/03/31[Date - Publication] AND ("English"[LA] OR"Japanese"[LA])(("breast neoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND "genetic*"[Text Word]))
AND ("Family"[MeSH] OR ("family history*"[TIAB] OR "Relatives"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR"cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("breast
neoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND "genetic*"[Text Word])) AND("Family"[MeSH] OR ("family history*"[TIAB] OR "Relatives"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND

BQ13

乳癌家族歴は乳("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH]

癌発症のリスクOR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR ((("breast neoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR

因子となるか？

"breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast
carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND "genetic*"[Text Word])) AND ("Family"[MeSH] OR ("family history*"[TIAB] OR"Relatives"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("ClinicalStudy"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR"observational stud*"[TIAB])) NOT (("breast neoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary
cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB]) AND "genetic*"[Text Word])) AND ("Family"[MeSH] OR ("family history*"[TIAB] OR "Relatives"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR"Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))

(((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Diabetes
Mellitus"[MeSH] OR "diabet*"[TIAB]) AND ("Risk"[MeSH] OR "Risk"[Text Word])) NOT ("Breast Neoplasms"[MeSH] AND "Diabetes Mellitus"[MeSH] AND ("Risk"[MeSH] OR "Risk"[AllFields]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR"Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB]
OR "control group*"[TIAB])) NOT ((((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR"breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND("Diabetes Mellitus"[MeSH] OR "diabet*"[TIAB]) AND ("Risk"[MeSH] OR "Risk"[Text Word])) NOT ("Breast Neoplasms"[MeSH] AND "Diabetes Mellitus"[MeSH] AND ("Risk"[MeSH] OR

BQ14

糖尿病の既往は"Risk"[All Fields]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR

乳癌発症リスク"systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) ORを増加させる((((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant

か？

neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Diabetes
Mellitus"[MeSH] OR "diabet*"[TIAB]) AND ("Risk"[MeSH] OR "Risk"[Text Word])) NOT ("Breast Neoplasms"[MeSH] AND "Diabetes Mellitus"[MeSH] AND ("Risk"[MeSH] OR "Risk"[AllFields]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB]
OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (((("Breast Neoplasms"[MeSH] OR("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant
tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Diabetes Mellitus"[MeSH] OR "diabet*"[TIAB]) AND("Risk"[MeSH] OR "Risk"[Text Word])) NOT ("Breast Neoplasms"[MeSH] AND "Diabetes Mellitus"[MeSH] AND ("Risk"[MeSH] OR "Risk"[All Fields]) AND 1000/01/01:2015/12/31[Date Publication])) AND ("English"[LA] OR "Japanese"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines
as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))

スタチンの服用
BQ15

は乳癌発症リス
クを減少させるか？

("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Hydroxymethylglutaryl-CoA Reductase Inhibitors"[MeSH] OR "Hydroxymethylglutaryl-CoA Reductase Inhibitors"[Pharmacological Action] OR ("statin"[TIAB] OR "statins"[TIAB])) AND("risk"[MeSH] OR "risk"[TIAB] OR "risks"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])低用量経口避妊薬（OC)や低用

CQ1

量エストロゲ("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

ン・プロゲスチOR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND

ン配合薬（LEP) ("contraceptives, oral"[MeSH] OR ("Oral Contraceptives"[TIAB] OR "Oral Contraceptive"[TIAB])) AND ("risk"[MeSH] OR "risk*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication]の使用は乳癌発症リスクを増加させるか？

AND ("JAPANESE"[LA] OR "ENGLISH"[LA])閉経後女性ホル
モン補充療法CQ2（HRT)は乳癌発症リスクを増加
させるか？
不妊治療におけFRQ1る排卵誘発は乳癌発症リスクを増加させるか？

日本人の乳癌発症リスク評価とFRQ2

して遺伝子多型情報を用いたモデルは有用か？

("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Hormone Replacement Therapy"[MeSH] OR ("hormone replacement therap*"[TIAB] OR "menopausal hormone therap*"[TIAB] OR "postmenopausal hormone therap*"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("ovulation induction"[MeSH] OR "reproductive techniques, assisted"[MeSH] OR "fertilization in vitro"[MeSH] OR ("fertility agents female"[Pharmacological Action] OR "fertility
agents"[MeSH]) OR ("fertility treatment*"[TIAB] OR "assisted reproductive techn*"[TIAB] OR "ovarian stimulation*"[TIAB] OR ("in vitro"[TIAB] AND "fertilization*"[TIAB])) OR"infertility"[MeSH]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(("Breast Neoplasms"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "medline"[Filter])) AND ("genes,
neoplasm"[MeSH] OR "Genetic Predisposition to Disease"[MeSH] OR ("gene*"[TIAB] AND ("predisposition"[TIAB] OR "susceptibility"[TIAB]))) AND ("Genetic Association
Studies"[MeSH] OR "genome"[TIAB]) AND ("asia"[MeSH] OR "Asian Continental Ancestry Group"[MeSH] OR "japan*"[TIAB])) NOT (("breast neoplasms/genetics"[MeSH] OR "breast
tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR"breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND ("polymorphism, genetic"[MeSH] OR "polymorphism*"[TIAB] OR "genomic structuralvariation*"[TIAB] OR "dna copy number variation*"[TIAB] OR "pharmacogenomic variant*"[TIAB]) AND ("Risk"[MeSH] OR "Risk"[TIAB] OR "Risks"[TIAB] OR "logistic model*"[TIAB] OR"protective factor*"[TIAB]) AND 1000/01/01:2015/12/31[Date - Publication])(("breast neoplasms/diagnostic imaging"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast
malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT"Medline"[Filter])) AND ("Breast Density"[MeSH] OR ("breast densit*"[TIAB] OR "mammographic densit*"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic
Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control
group*"[TIAB])) NOT ((("breast neoplasms/diagnostic imaging"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary
cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary
neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("Breast Density"[MeSH] OR ("breast densit*"[TIAB] OR "mammographic densit*"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR

BQ16

マンモグラフィ"Risks"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] ORの乳房構成は乳"systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR

癌発症リスクと((("breast neoplasms/diagnostic imaging"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast

関連するか？

malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT"Medline"[Filter])) AND ("Breast Density"[MeSH] OR ("breast densit*"[TIAB] OR "mammographic densit*"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical
trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("breast neoplasms/diagnostic imaging"[MeSH] OR(("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant
tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("Breast Density"[MeSH] OR ("breast
densit*"[TIAB] OR "mammographic densit*"[TIAB])) AND ("Risk"[MeSH] OR ("Risk"[TIAB] OR "Risks"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR"ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("metaanalysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter])))))

(("breast neoplasms/prevention and control"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast
malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND("prevent*"[TIAB] OR "control"[TIAB]))) AND ("Aromatase Inhibitors"[MeSH] OR "Aromatase Inhibitors"[Pharmacological Action] OR "aromatase inhibitor*"[TIAB] OR ("Hormone
Antagonists"[MeSH] OR "Hormone Antagonists"[Pharmacological Action]) OR "hormone antagonist*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR"ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative
stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("breast neoplasms/prevention andcontrol"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast
malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND ("prevent*"[TIAB] OR "control"[TIAB]))) AND("Aromatase Inhibitors"[MeSH] OR "Aromatase Inhibitors"[Pharmacological Action] OR "aromatase inhibitor*"[TIAB] OR ("Hormone Antagonists"[MeSH] OR "Hormone
乳癌の発症を予BQ17防するために薬剤を投与することは有用か？

Antagonists"[Pharmacological Action]) OR "hormone antagonist*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane
Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR"systematic review"[Title]) NOT "Medline"[Filter]))) OR ((("breast neoplasms/prevention and control"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast
cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary
carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND ("prevent*"[TIAB] OR "control"[TIAB]))) AND ("Aromatase Inhibitors"[MeSH] OR "Aromatase Inhibitors"[Pharmacological
Action] OR "aromatase inhibitor*"[TIAB] OR ("Hormone Antagonists"[MeSH] OR "Hormone Antagonists"[Pharmacological Action]) OR "hormone antagonist*"[TIAB]) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical
trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (("breast neoplasms/prevention and control"[MeSH]
OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant
tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) AND ("prevent*"[TIAB] OR "control"[TIAB]))) AND ("Aromatase
Inhibitors"[MeSH] OR "Aromatase Inhibitors"[Pharmacological Action] OR "aromatase inhibitor*"[TIAB] OR ("Hormone Antagonists"[MeSH] OR "Hormone Antagonists"[Pharmacological
Action]) OR "hormone antagonist*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR"meta analysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT

BRCA病的バリアントをもつ女性
CQ3にリスク低減乳房切除術（RRM）は勧められるか？

"Medline"[Filter])))))((("breast neoplasms/prevention and control"[MeSH] OR "breast neoplasms/genetics"[MeSH] OR "ovarian neoplasms/prevention and control"[MeSH] OR "ovarianneoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR "ovarian neoplasm*"[TIAB] OR "ovary
neoplasm*"[TIAB] OR "ovary cancer*"[TIAB] OR "ovarian cancer*"[TIAB]) NOT "medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR"brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2 mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR ("Hereditary Breast andOvarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND ("Mastectomy"[MeSH] OR "mastectom*"[TIAB] OR "mammectom*"[TIAB]) AND ("Risk"[MeSH] OR "risk reduction*"[TIAB]
OR "risk reducing*"[TIAB] OR "risk management*"[TIAB] OR "prophylactic*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])((("breast neoplasms/prevention and control"[MeSH] OR "breast neoplasms/genetics"[MeSH] OR "ovarian neoplasms/prevention and control"[MeSH] OR "ovarian
BRCA病的バリア neoplasms/genetics"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

CQ4ントをもつ乳癌

OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR "ovarian neoplasm*"[TIAB] OR "ovary

患者にリスク低neoplasm*"[TIAB] OR "ovary cancer*"[TIAB] OR "ovarian cancer*"[TIAB]) NOT "medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR

減卵管卵巣切除"brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2 mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR ("Hereditary Breast and術（PRSO)は勧Ovarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND ((("fallopian tubes/surgery"[MeSH] OR "fallopian tube neoplasms/prevention and control"[MeSH]) AND

められるか？

"Ovariectomy"[MeSH]) OR ("salpingo oophorectom*"[TIAB] OR "RRSO"[TIAB] OR "PSO"[TIAB])) AND ("Risk"[MeSH] OR "risk reduction*"[TIAB] OR "risk reducing*"[TIAB] OR "riskmanagement*"[TIAB] OR "prophylactic*"[TIAB]) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(((("Breast Neoplasms"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR "brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2 mutation*"[TIAB] OR "brcagene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR ("Hereditary Breast and Ovarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND ("Mastectomy"[MeSH] OR"mastectom*"[TIAB] OR "mammectom*"[TIAB] OR ("mastectomy, segmental"[MeSH] OR "segmentectom*"[TIAB] OR "lumpectom*"[TIAB] OR "breast conserving surger*"[TIAB] OR"breast quadrantectom*"[TIAB] OR "breast conservation therap*"[TIAB] OR "breast sparing surger*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR"ENGLISH"[LA]) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative
stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((((("Breast Neoplasms"[MeSH] OR (("breast
tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR"breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brcamutation*"[TIAB] OR "brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2 mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR
BRCA病的バリアントをもつ乳癌
CQ5

患者に乳房温存
療法は勧められるか？

("Hereditary Breast and Ovarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND ("Mastectomy"[MeSH] OR "mastectom*"[TIAB] OR "mammectom*"[TIAB] OR ("mastectomy,
segmental"[MeSH] OR "segmentectom*"[TIAB] OR "lumpectom*"[TIAB] OR "breast conserving surger*"[TIAB] OR "breast quadrantectom*"[TIAB] OR "breast conservation therap*"[TIAB]
OR "breast sparing surger*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "metaanalysis"[PT] OR "systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT"Medline"[Filter]))) OR ((((("Breast Neoplasms"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast
malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT"Medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR "brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2
mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR ("Hereditary Breast and Ovarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND("Mastectomy"[MeSH] OR "mastectom*"[TIAB] OR "mammectom*"[TIAB] OR ("mastectomy, segmental"[MeSH] OR "segmentectom*"[TIAB] OR "lumpectom*"[TIAB] OR "breast
conserving surger*"[TIAB] OR "breast quadrantectom*"[TIAB] OR "breast conservation therap*"[TIAB] OR "breast sparing surger*"[TIAB])) AND 2016/01/01:2021/03/31[Date Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinicalstud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])) NOT (((("Breast Neoplasms"[MeSH] OR (("breast tumor*"[TIAB] OR "breast
neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB]
OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT "Medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR "brca1
mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2 mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB])) OR ("Hereditary Breast andOvarian Cancer Syndrome"[MeSH] OR "HBOC"[TIAB])) AND ("Mastectomy"[MeSH] OR "mastectom*"[TIAB] OR "mammectom*"[TIAB] OR ("mastectomy, segmental"[MeSH] OR"segmentectom*"[TIAB] OR "lumpectom*"[TIAB] OR "breast conserving surger*"[TIAB] OR "breast quadrantectom*"[TIAB] OR "breast conservation therap*"[TIAB] OR "breast sparing
surger*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR((("breast neoplasms/prevention and control"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast
malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT
BRCA病的バリア "medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR "brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2ントをもつ乳癌
FRQ３ 患者に対し予防

mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB] OR "breast neoplasms/genetics"[MeSH])) OR ("hereditary breast and ovarian cancer
syndrome/prevention and control"[MeSH] OR ("HBOC"[TIAB] NOT "medline"[Filter]))) AND ("antineoplastic agents, hormonal"[MeSH] OR "antineoplastic agents

的内分泌療法はhormonal"[Pharmacological Action] OR ("antineoplastic hormonal drug*"[TIAB] OR "hormonal antineoplastic*"[TIAB] OR "antineoplastic hormonal agent*"[TIAB]) OR ("estrogen

勧められるか？

antagonists/therapeutic use"[MeSH] OR "Estrogen Antagonists"[Pharmacological Action]) OR ("estrogen antagonist*"[TIAB] OR "estradiol antagonist*"[TIAB]) OR ("endocrine
therap*"[TIAB] OR "endocrine treatment*"[TIAB]) OR ("estrogen receptor modulators/therapeutic use"[MeSH] OR "Estrogen Receptor Modulators"[Pharmacological Action])) AND
2016/01/01:2021/03/31[Date - Publication]((("breast neoplasms/prevention and control"[MeSH] OR (("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast

乳癌未発症のBRCA病的バリア
FRQ4ント保持者に対し予防的内分泌療法は勧められるか？

malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB]) NOT"medline"[Filter])) AND ("genes, brca1"[MeSH] OR "genes, brca2"[MeSH] OR "brca mutation*"[TIAB] OR "brca1 mutation*"[TIAB] OR "brca2 mutation*"[TIAB] OR "brca1 2
mutation*"[TIAB] OR "brca gene*"[TIAB] OR "brca1 gene*"[TIAB] OR "brca2 gene*"[TIAB] OR "breast neoplasms/genetics"[MeSH])) OR ("hereditary breast and ovarian cancer
syndrome/prevention and control"[MeSH] OR ("HBOC"[TIAB] NOT "medline"[Filter]))) AND ("antineoplastic agents, hormonal"[MeSH] OR "antineoplastic agentshormonal"[Pharmacological Action] OR ("antineoplastic hormonal drug*"[TIAB] OR "hormonal antineoplastic*"[TIAB] OR "antineoplastic hormonal agent*"[TIAB]) OR ("estrogenantagonists/therapeutic use"[MeSH] OR "Estrogen Antagonists"[Pharmacological Action]) OR ("estrogen antagonist*"[TIAB] OR "estradiol antagonist*"[TIAB]) OR ("endocrine
therap*"[TIAB] OR "endocrine treatment*"[TIAB]) OR ("estrogen receptor modulators/therapeutic use"[MeSH] OR "Estrogen Receptor Modulators"[Pharmacological Action])) AND
2016/01/01:2021/03/31[Date - Publication]

((((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant
neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Pregnancy"[MeSH] OR"Postpartum Period"[MeSH] OR "Peripartum Period"[MeSH] OR "Lactation"[MeSH] OR ("Pregnancy"[TIAB] OR "postpartum"[TIAB] OR "peripartum"[TIAB] OR "breastfeeding"[TIAB] OR"Lactation"[TIAB])) AND ("Prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR"mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB]))) NOT ("Breast Neoplasms"[MeSH] AND ("Pregnancy"[MeSH] OR ("Lactation"[MeSH] OR "Breast Feeding"[MeSH])) AND("Prognosis"[MeSH] OR "Prognosis"[All Fields]) AND 0001/01/01:2015/12/31[Date - Publication])) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR"systematic"[Filter] OR "Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR "meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title])) OR (((("Breast
Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR"breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("Pregnancy"[MeSH] OR "Postpartum
妊娠期・授乳期BQ18の乳癌は予後が不良か？

Period"[MeSH] OR "Peripartum Period"[MeSH] OR "Lactation"[MeSH] OR ("Pregnancy"[TIAB] OR "postpartum"[TIAB] OR "peripartum"[TIAB] OR "breastfeeding"[TIAB] OR"Lactation"[TIAB])) AND ("Prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR"mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB]))) NOT ("Breast Neoplasms"[MeSH] AND ("Pregnancy"[MeSH] OR ("Lactation"[MeSH] OR "Breast Feeding"[MeSH])) AND("Prognosis"[MeSH] OR "Prognosis"[All Fields]) AND 0001/01/01:2015/12/31[Date - Publication])) AND ("Epidemiologic Research Design"[MeSH] OR "Study Characteristics"[PT] OR"Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB]
OR "control group*"[TIAB])) OR (((("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR"breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND("Pregnancy"[MeSH] OR "Postpartum Period"[MeSH] OR "Peripartum Period"[MeSH] OR "Lactation"[MeSH] OR ("Pregnancy"[TIAB] OR "postpartum"[TIAB] OR "peripartum"[TIAB] OR"breastfeeding"[TIAB] OR "Lactation"[TIAB])) AND ("Prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR"recurrence*"[TIAB] OR "mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB]))) NOT ("Breast Neoplasms"[MeSH] AND ("Pregnancy"[MeSH] OR ("Lactation"[MeSH] OR "Breast
Feeding"[MeSH])) AND ("Prognosis"[MeSH] OR "Prognosis"[All Fields]) AND 0001/01/01:2015/12/31[Date - Publication])) AND ("Clinical Study"[PT] OR "Clinical Studies as
Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB]))) AND

CQ6

CQ7

肥満は乳癌患者("English"[LA] OR "Japanese"[LA])Breast Neoplasms[MH] AND ("Neoplasm Recurrence, Local"[MH] OR "Recurrence"[MH] OR "Prognosis" [MH] OR "Antineoplastic Agents, Hormonal"[MH]) AND ("Obesity"[MH] OR "Bodyの予後に影響を

Mass Index"[MH] OR "Body Weight"[MH]) AND ("Cohort Studies"[MH] OR "Meta-Analysis"[PT] OR "Practice Guideline"[PT] OR "Randomized Controlled Trial"[PT] OR systematic[SB])及ぼすか？

AND "Humans"[MH] AND (English[LA] OR Japanese[LA]) AND (2016/1[DP] : 2021/3[DP])乳癌初期治療後("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]の食事による脂OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "cancer

肪摂取は乳癌患

patient*"[TIAB]))) AND ("dietary fats"[MeSH] OR ("dietary fat"[TIAB] OR "dietary fats"[TIAB] OR ("fat intake"[TIAB] OR "fat intakes"[TIAB]) OR "fats intake"[TIAB] OR ("Fat"[TIAB] AND

者の予後に影響"diet"[TIAB]))) AND ("neoplasm recurrence, local"[MeSH] OR "Prognosis"[MeSH] OR "survival analysis"[MeSH] OR "mortality"[MeSH] OR "mortality"[MeSH Subheading] ORを及ぼすか？

("recurrence*"[TIAB] OR "prognos*"[TIAB] OR "survival*"[TIAB] OR "mortalit*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("motor activity"[MeSH] OR"exercise"[MeSH] OR "sports"[MeSH] OR ("motor activit*"[TIAB] OR "exercise"[TIAB] OR "exercises"[TIAB] OR "sport"[TIAB] OR "sports"[TIAB] OR "athletic"[TIAB] OR"athletics"[TIAB])) AND ("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR"mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Epidemiologic
Research Design"[MeSH] OR "Study Characteristics"[PT] OR "Epidemiologic Study Characteristics"[MeSH] OR "cohort*"[TIAB] OR "comparative stud*"[TIAB] OR "retrospective
stud*"[TIAB] OR "prospective stud*"[TIAB] OR "longitudinal*"[TIAB] OR "control group*"[TIAB])) NOT ((("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast

CQ8

乳癌患者に対しneoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB]て身体活動を高OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("motor activity"[MeSH] OR "exercise"[MeSH] OR "sports"[MeSH] OR ("motor activit*"[TIAB] OR

く維持すること"exercise"[TIAB] OR "exercises"[TIAB] OR "sport"[TIAB] OR "sports"[TIAB] OR "athletic"[TIAB] OR "athletics"[TIAB])) AND ("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH]

は勧められるOR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR "mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB])) ANDか？

2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Cochrane Database Syst Rev"[Journal] OR "meta analysis"[PT] OR "systematic"[Filter] OR"Guideline"[PT] OR "Guidelines as Topic"[MeSH] OR (("meta analysis"[Title] OR "guideline*"[Title] OR "systematic review"[Title]) NOT "Medline"[Filter]))) OR (("breast
neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR"breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB])) AND ("motor activity"[MeSH] OR "exercise"[MeSH]
OR "sports"[MeSH] OR ("motor activit*"[TIAB] OR "exercise"[TIAB] OR "exercises"[TIAB] OR "sport"[TIAB] OR "sports"[TIAB] OR "athletic"[TIAB] OR "athletics"[TIAB])) AND("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR "mortality"[TIAB] OR"mortalities"[TIAB] OR "survival*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA]) AND ("Clinical Study"[PT] OR "Clinical Studies as
Topic"[MeSH] OR "random*"[TIAB] OR "clinical trial*"[TIAB] OR "clinical stud*"[TIAB] OR "case control*"[TIAB] OR "case comparison*"[TIAB] OR "observational stud*"[TIAB])))("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

CQ9アルコールの摂OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "cancer

取は乳癌患者のpatient*"[TIAB]))) AND ("Alcohol Drinking"[MeSH] OR "alcoholic beverages"[MeSH] OR ("Alcohol Drinking"[TIAB] OR "alcohol intake*"[TIAB] OR "alcohol use*"[TIAB] OR "alcohol

予後と関連する

consum*"[TIAB] OR "alcoholic drink*"[TIAB])) AND ("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "mortality"[MeSH Subheading] ORか？

"survival"[MeSH] OR "survival analysis"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR "mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB])) AND
2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])("Breast Neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]

喫煙は乳癌患者
CQ10の予後と関連するか？

OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "cancer
patient*"[TIAB]))) AND ("Smoking"[MeSH] OR "Smoking Cessation"[MeSH] OR "Tobacco Smoke Pollution"[MeSH] OR ("Smoking"[TIAB] OR "smokings"[TIAB] OR "smoke"[TIAB] OR"smokes"[TIAB] OR "smoker"[TIAB] OR "smokers"[TIAB] OR "tobacco"[TIAB] OR "tobaccos"[TIAB] OR "cigar"[TIAB] OR "cigars"[TIAB] OR "cigarette"[TIAB] OR "cigarettes"[TIAB])) AND("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "mortality"[MeSH] OR "survival"[MeSH] OR "survival analysis"[MeSH] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR"mortality"[TIAB] OR "mortalities"[TIAB] OR "survival*"[TIAB])) AND 2016/01/01:2021/03/31[Date - Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])(("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND

CQ11

食事によるイソ("soy foods"[MeSH] OR "isoflavones"[MeSH] OR "Equol"[MeSH] OR ("soybean*"[TIAB] OR "Soy"[TIAB] OR "isoflavone*"[TIAB] OR "Equol"[TIAB])) AND ("prognosis"[MeSH] OR

フラボン摂取は"neoplasm recurrence, local"[MeSH] OR "Survival Analysis"[MeSH] OR "mortality"[MeSH] OR "mortality"[MeSH Subheading] OR ("prognos*"[TIAB] OR "recurrence*"[TIAB] OR

乳癌患者の予後"survival*"[TIAB] OR "mortalit*"[TIAB])) AND 1000/01/01:2021/03/31[Date - Publication]) NOT (("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] ORに影響を及ぼす"breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB] OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammaryか？

carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND ("soy foods"[MeSH] OR "isoflavones"[MeSH] OR ("soybean*"[TIAB] OR "Soy"[TIAB]
OR "isoflavone*"[TIAB])) AND ("prognosis"[MeSH] OR "neoplasm recurrence, local"[MeSH] OR "Survival Analysis"[MeSH] OR "mortality"[MeSH] OR "mortality"[MeSH Subheading] OR("prognos*"[TIAB] OR "recurrence*"[TIAB] OR "survival*"[TIAB] OR "mortalit*"[TIAB])) AND 1000/01/01:2015/12/31[Date - Publication])

乳製品の摂取は
CQ12

乳癌患者の予後に影響を及ぼすか？

("breast neoplasms"[MeSH] OR ("breast tumor*"[TIAB] OR "breast neoplasm*"[TIAB] OR "breast cancer*"[TIAB] OR "mammary cancer*"[TIAB] OR "breast malignant neoplasm*"[TIAB]
OR "breast malignant tumor*"[TIAB] OR "breast carcinoma*"[TIAB] OR "mammary carcinoma*"[TIAB] OR "mammary neoplasm*"[TIAB] OR ("Breast"[TIAB] AND "Cancer"[TIAB]))) AND("Dairy Products"[MeSH] OR "Dietary Fats"[MeSH] OR "diet"[MeSH Major Topic] OR ("dairy product*"[TIAB] OR "dietary fat*"[TIAB])) AND ("neoplasm recurrence, local"[MeSH] OR"prognosis"[MeSH] OR ("mortality"[MeSH] OR "mortality"[MeSH Subheading]) OR ("recurrence*"[TIAB] OR "prognos*"[TIAB] OR "mortalit*"[TIAB])) AND 2016/01/01:2021/03/31[Date Publication] AND ("JAPANESE"[LA] OR "ENGLISH"[LA])((("breast neoplasms/therapy"[MeSH] OR "breast neoplasms/psychology"[MeSH]) AND ("Psychotherapy"[MeSH] OR "Social Support"[MeSH] OR "Mental Health"[MeSH] OR

心理社会的介入CQ13

は乳癌患者に有用か？

"psychosocial intervention"[TIAB] OR "Social Support"[TIAB]) AND ("Clinical Trial"[PT] OR "Cohort Studies"[MeSH] OR "Meta-Analysis"[PT] OR "Practice Guideline"[PT] OR "Randomized
Controlled Trial"[PT] OR "systematic"[Filter] OR "Comparative Study"[PT] OR "Multicenter Study"[PT] OR "Case-Control Studies"[MeSH])) NOT (("breast neoplasms/therapy"[MeSH] OR"breast neoplasms/psychology"[MeSH]) AND ("Psychotherapy"[MeSH] OR "Social Support"[MeSH] OR "psychosocial intervention"[All Fields]) AND ("Clinical Trial"[PT] OR "Cohort
Studies"[MeSH] OR "Meta-Analysis"[PT] OR "Practice Guideline"[PT] OR "Randomized Controlled Trial"[PT] OR "systematic"[Filter] OR "Comparative Study"[PT] OR "Multicenter
Study"[PT] OR "Case-Control Studies"[MeSH]) AND 1000/01/01:2015/12/31[Date - Publication])) AND ("English"[LA] OR "Japanese"[LA])