LMARPATSM
Subject
Coverage• Markush patents covered in CAplus• Organo or organometallic molecules• Polymers not included

File Type

Markush Structure, Training

Features

Thesaurus

None

Alerts (SDIs)

None

CAS Registry®
NumberIdentifiersPage Images



STN AnaVist™

Keep & Share




SLART




STN EasySM

Learning
Database

Structures

®




®

RecordContent• Markush structures found in the claims and often the disclosure of the patent,
bibliographic information, patent family information, cited references®
• In-depth substance and subject indexing including CAS Registry Numbers , and an
abstract, all of which are displayable• The structures are searchable
SM• Document information can be searched in CA and CAplus

File Size

569 records (02/16)

Coverage

Selected Markush structure records for patents found in CAplus with the patentpublication year of 1988-1989

Updates

None

Language

English

Database
Producer

Chemical Abstracts Service
2540 Olentangy River Road
P.O. Box 3012
Columbus, Ohio 43210-0012 USA
Phone: 800-753-4227 (North America)
Phone: 614-447-3700 (worldwide)Fax:
614-447-3751
Email: help@cas.org
Copyright Holder

February 2016

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LMARPAT

Sources

Selected Markush patents found in CAplus

User Aids• Online Helps (HELP DIRECTORY lists all help messages available)• STNGUIDE

Clusters• LEARNING
STN Database Clusters Information (PDF).

RelatedDatabases

MARPAT

PricingEnter HELP COST at an arrow prompt (=>).

February 2016

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LMARPATSEARCH and DISPLAY Field Codes
There are no fields that allow left truncation.
SearchCode

Search Field Name

Display
Codes

Search Examples

Basic Index (contains single words
from the textual information
associated with the Markush
structures) (1)None (or/BI)

S MESOS PHARMACEUT? (L) SALT#MSTR

Accession Number
Entry Date (2)Update Date (2)

/AN
/ED
/UP

S 118:93622/AN
S 19990305/ED
S L1 AND UP>=19990100

AN
Not displayed
Not displayed(1) Only structure-related text terms are included; terms from the CAplus Basic Index are not searchable.
(2) Numeric search field that may be searched using numeric operators or ranges.

Structure Search Terms
Novice SEARCH provides prompts to allow you to modify some query attributes, e.g., MLEVEL, before
search is run.
Term
L-number of a structure built using the STRUCTURE command or uploaded
from STN Express (1)Search Examples
SEARCH L1 CSS FUL
S L2
S L7 SUBSET=L5(1) The L-number answer set from a structure search may be combined with text terms, e.g., S L6 AND SALTS.

Types of Structure Searching
Novice SEARCH provides prompts to allow you to modify some query attributes, e.g., MLEVEL, before thesearch is run.
Type
Substructure(default)
ClosedSubstructure

Definition
Search for substances that match the query.
Substitution is allowed at all open positions.
Search for substances that match the query exactly.
Substitution is allowed at positions opened by
CONNECT.

Search Code
SSS
CSS

Search Examples
SEARCH L1 SSS FUL
S L2SEARCH L1 CSS FUL
SEA L4 CSS SUB=L2

February 2016

4
LMARPAT

Scopes of Structure Searches
Novice SEARCH provides prompts to allow you to modify some query attributes, e.g., MLEVEL, before thesearch is run.
To create an L-number answer set containing candidate structures that have passed the screening step ofyour structure search, enter EXTEND on the search command line or enter SET EXTEND ON or SET
EXTEND ON PERM at an arrow prompt (=>). For details, enter HELP SET EXTEND at an arrow prompt.
Scope

Definition

Sample (default)(1)
Full
Range
Subset Sample

Search a fixed 5% of the file
Search 100% of the file
Search a user-specified portion of the file
Search a fixed sample of an answer set created bya search in MARPAT
Search a user-specified portion of an answer
created by a search in MARPAT
Search 100% of an answer set created by a searchin MARPAT

Subset Range
Subset Full

Search CodeSearch Examples

SAM
FUL
RAN
SUB SAMSEARCH L1 SAM SSS
S L5 SSS FUL
S L4 RAN=(V117,)
S L7 CSS SUB=L5 SAM

SUB RANRAN=(V118)SUB FULS L3 SUB=L2
S L8 SUB=L6 FUL(1) EXTEND is not valid with SAMPLE.

DISPLAY Formats
Any combination of formats may be used to display answers. Multiple codes must be separated by spaces orcommas. The fields are displayed in the order requested, e.g., D TI AU. The PRINT command is not valid in
MARPAT. The default Generic Group display (expanded form) has GTEXT set to ON. To use the compact
form, enter SET GTEXT OFF at an arrow prompt (=>).
Hit-term highlighting is available in the AN and MSTR fields. MARHIGHLIGHT must be ON during SEARCH inorder to use HIT, FHIT, FQHIT, and QHIT formats.
FormatContent

AB
AI (AP) (1)AI.B (AP.B) (1)AN

Abstract Text
Patent Application Information
Patent Application Information, Basic
Accession Number

ANPLCC
CT (2)CYA (2)CYC (CY.CNT) (2)DS (2)
DS.B (2)DT (TC)FS (2)
GI (3)
ICA
ICI
ICM
ICS
IN (AU)ISN (2)IT (4)LAMSTR
MSTR(n) (2)NCLOS

AN and CAplus Accession Number
CA Classification Code (CA section and section cross-references)
Controlled Term
Country of Author
Patent Country Count
Designated States
Designated States, Basic
Document Type
File Segment (Section Group)
Graphic Image or Graphic Image Information
Additional or Supplementary IPC
Index or Complementary IPC
Main IPC
Secondary IPC
Inventor Name
International Standard (Document) Number
Index Term and CAS role
Language
All Markush structures and related text
Markush structure n and its related text
National Patent Classification
Other Source

February 2016

ExamplesD AB
D AI PI
D AI.BDISPLAY L2 1-10 ANHIT
D ANPL
D CC
D CT
D CYA
D CYC
D PI DS
D DS.B
D DT
D FS
D GI
D 2-10 ICA
D 5 8 ICI
D ICM
D ICS
D IN
D ISN
D AN IT
D LA
D AN MSTR
D AN MSTR (1)
D NCL
D OS

5
LMARPATDISPLAY Formats (cont'd)FormatContent

ExamplesPA (CS)PI (1)
PI.B (PN.B) (1,2)
PN
PNC (PN.CNT) (2)
PNK
PNK.B
PRAI (PRN) (1)
PRAI.B (PRN.B)(1)
PY (2)
PY.B (2)RE (3)RETABLE (2,3)
RE.CNT (REC) (3)RL (4)
RN (2)SO
ST
SX (2,5)TI

Patent Assignee
Patent Information Table
Patent Information, Basic
Patent Number
Patent Number Count
Patent Number/Kind CodePatent Number/Kind Code, BasicPriority Application Information
Priority Application Information, Basic
Publication Year
Publication Year, Basic
Cited References
Cited References Table
Citing Document's Reference Count
Index Term and CAS role
CAS Registry Numbers
SourceSupplementary Term (CA keyword)
CA Section Cross-Reference Code
Title of Document

D PA
D TI PI
D PI.B
D PN
D PNC
D PNK
D PNK.B
D AI PRAID PRAI.B
D PY
D TI PY.B
D TI RE
D TI AU RETABLE
D REC
D RL
D AN RN
D TI AU SO
D ST
D TI SXD TI MSTRABS
ALL (1,4)

GI, ABAN, TI, IN, PA, SO, DT, LA, NCL, CC, FAN.CNT, PI, PRAI, OS, GI,
AB, ST, IT, RL, RE.CNT, RE, MSTR
AI, PRAI
AI.B, PRAI.B
AN, TI, IN, PA, SO, DT, LA, FAN.CNT, PI, PRAI, OS, RE.CNT (BIB
is the default)
List of CA Abstract Numbers (no L-number header)AN, plus Compressed Bibliographic Data
ALL, delimited for post-processing
MAX, delimited for post-processing
AN, FAN.CNT, PI for the accession number, plus PI for other family
accession numbers
Family Accession Number (AN, FAN.CNT, FAN)
BIB plus PI for other family accession numbers
ABS, with text labels
ALL, indented with text labels
BIB, indented with text labels
International Patent Classification, Main and SecondaryAN, MSTR
MAX, indented with text labels
IPC, NCL, CC, ST, IT, RL
International Patent Classifications (IC (ICM, ICS), ICA, ICI)
STD, indented with text labels
ALL, plus PI for other family accession numbers
BIB, Original (AN, TI, IN, PA, SO, PI, DS, AI, PRAI, DT, LA, OS)
OBIB, indented with text labels
SO, PI
IPC, NCL, CC, SX, TI, ST, IT, and FQHIT
BIB, without RE.CNT (AN, DN, TI, AU, IN, CS, PA, SO, PB, DT, LA,
FAN.CNT, PI, PRAI, OS)
IPC, NCL, CC, TI, ST, IT, RL, FQHIT (random display, no answer
numbers)
SBIB, indented with text labels
AN, TI, IN, PA, SO, DT, LA, FAN.CNT, PI, PRAI, NCL, OS, RE.CNT

D ABS
D L2 1-7 ALL

APPS (1)
APPS.B (1)BIB (1)CANCBIBDALL (1,4)
DMAX (1,4)
FAM (1)FANFBIB (1)
IABS
IALL (1,4)
IBIB (1)IC
IDE
IMAX (1,4)
IND (4)IPC
ISTD (1)
MAX (1,4)
OBIB (1)
OIBIB (1)
PATS (1)
SAM (4)
SBIB (1)
SCAN (3,4,6)
SIBIB (1)
STD (1)D APPSD APPS.B
D 1-3 BIB HITD CANDISPLAY L1 1 CBIBD DALL
D MAX
D FAM
D FAN
D FBIBD IABSD IALLD IBIBD IC
D IDE
D IMAX
D TI IND
D IPC
D ISTDD MAX
D OBIBD OIBIBD PATSDIS SAM 1-5
D 1 3 SBIBD SCAND SIBIBD STD

February 2016

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LMARPATDISPLAY Formats (cont'd)FormatFHIT
FQHIT (7,8)
FQHITEXG (7,9)
HIT
QHIT (7,8)
QHITEXG (7,9)

Content

ExamplesThe first full Markush structure that matches the query structure and(or) the fields containing hit text terms
Portions of the first Markush structure that match the query structureand (or) fields containing the first query focus hit text terms
FQHIT plus definitions for unmatched G-groups that are visible in theassembled display
The full Markush structure(s) that match the query structure and (or)the fields containing hit text terms
The portions of each Markush structure that match the query
structure and (or) the fields containing hit text terms

D CBIB ABS FHITQHIT plus definitions for unmatched G-groups that are visible in theassembled display

D QHITEXGD FQHITD FQHITEXGD CBIB ABS HITD QHIT(1) By default, patent, application, and priority numbers are displayed in STN format. To display them in Derwent format, enter SET
PATENT DERWENT at an arrow prompt. To reset display to STN format, enter SET PATENT STN.
(2) Custom display only.
(3) No online display fee for this format.
(4) By default, roles are displayed as codes and text. To suppress the display of role codes and text, enter SET ROLES OFF. To display
only codes, enter SET ROLES CODES.
(5) SX displays all information in the CC field, i.e., CA section and section cross-references.
(6) SCAN must be specified on the command line, i.e., D SCAN or DISPLAY SCAN.
(7) SET MPTASSEMBLY command allows you to control answer assembly formats and is set ON as a system default. To change the
MARPAT display, enter SET MPTASSEMBLY BOTH or SET MPTASSEMBLY OFF. If MPTASSEMBLY is set to BOTH or ON andassembly is not possible, only the unassembled display will be shown. For more information on SET MPTASSEMBLY see HELP T13
in MARPAT.
(8) If you want to retain the original FQHIT/QHIT format, SET MPTASSEMBLY OFF.
(9) Even if MPTASSEMBLY is set to OFF, the unmatched G-group definitions available in the QHITEXG and FQHITEXG formats will only
be shown with assembled displays. If MPTASSEMBLY is set to BOTH, an unassembled display will follow.

Displaying CAplus or MEDLINE documents for cited references
Enter the following in the DISPLAY command: L-number for the answer set; answer number (only one may be
specified); RAN.CAPLUS(x-y), RAN.MED(x-y) where (x-y) is the cited reference number, numbers, or rangeof numbers; and the display format for the document to display, e.g., BIB ABS. For example, to display
CAplus records for the cited references 1 and 2 from answer 2 in the answer set L5, enter the following:=> D RAN.CAPLUS(1-2) L5 2 BIB ABS

SELECT, ANALYZE, and SORT Fields
The SELECT command is used to create E-numbers containing terms taken from the specified field in ananswer set.
The ANALYZE command is used to create an L-number containing terms taken from the specified field in ananswer set.
The SORT command is used to rearrange the search results in either alphabetic or numeric order of thespecified field(s).
Field Name
Abstract Text
Accession Number
Author (Inventor)
CA Classification Code (section and subsection)
CA Section Cross-Reference CodeCAS Registry Number
CAS Role
Cited References
Cited Reference(n)February 2016

Field Code
AB
AN
AU
CC
SX
RN
RL
RE
RE(n)

ANALYZE/
SELECT
Y
Y (1)
Y
Y
Y
Y (2)
Y
Y
Y (3)

SORT
N
N
Y
Y
Y
N
N
N
N

7
LMARPATSELECT, ANALYZE, and SORT Fields (cont'd)
Field Name
Cited Reference Accession Number in CAplus
Cited Reference Accession Number(n) in CAplus
Cited Reference Accession Number in MEDLINE
Cited Reference Accession Number(n) in MEDLINE
Cited Reference Author Name
Cited Reference Count
Cited Reference Patent Number
Cited Reference Publication Year
Cited Reference Work Title
CODEN
Controlled Term
Corporate Source (Patent Assignee)Country Name of Author
Designated State
Designated States, Basic
Document Type
Family Accession Number
File Segment
Index Term
International Standard (Document) Number
International Standard Serial Number
Inventor Name
IPC
IPC, Additional or Supplementary
IPC, Index or Complementary
IPC, Main
IPC, Main and Secondary
IPC, Secondary
Journal Type
Language
National Patent Classification
Other Source
Patent Application Country
Patent Application Country, Basic
Patent Application Date
Patent Application Date, Basic
Patent Application Information
Patent Application Information, Basic
Patent Application Number
Patent Application Number, Basic
Patent Application and Priority Number
Patent Application and Priority Number, Basic
Patent Application Year
Patent Application Year, Basic
Patent Assignee
Patent Countries
Patent Countries, Basic
Patent Country
Patent Country, Basic
Patent Country Count
Patent Information
Patent Information, Basic
Patent Kind CodePatent Kind Code, Basic
Patent Number

Field CodeANALYZE/
SELECT

SORT

RAN.CAPLUS
RAN.CAPLUS(n)RAN.MED
RAN.MED(n)RAU
RIN
RE.CNTREC

Y (4)
Y (3,4)Y (5)Y (3,5)
Y
Y (6)
Y
Y

N
N
N
N
N
N
Y
Y

RPN
RPY
RWK
CODEN
CT
CS
CYA
DS
DS.B
DT
FAN
FS
IT
ISN
ISSN
IN
IPC
ICA
ICI
ICM
IC
ICS
JT
LA
NCL
OS
AC
AC.B
AD
AD.B
AI
AI.B
AP
AP.B
APPS
APPS.B
AY
AY.B
PA
PCS
PCS.B
PC
PC.B
CYC
PI
PI.B
PK
PK.B
PN
PATS

Y
Y
Y
Y (7)
Y
Y
Y
Y
Y (8)
Y
Y (9)
Y
Y
Y (10)YY
Y (11)
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y (12)Y
Y (13)Y (14,15)
Y (15,16)
Y (15)Y (15,17)
Y (15,18)
Y (15,19)
Y
Y (20)Y
Y (21)Y (22)Y
Y (23)Y (24)Y (15,25)
Y (15,26)
Y
Y (27)Y (15)Y (15,28)

N
N
N
Y
N
Y
Y
N
N
Y
N
Y
N
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
N
N
Y
Y
Y
N
N
Y
Y
N
Y
Y
Y
Y
Y
N

February 2016

8
LMARPATSELECT, ANALYZE, and SORT Fields (cont'd)
Field Name

Field CodeANALYZE/
SELECT

SORT

Patent Number Count
Patent Number/Kind CodePatent Number/Kind Code, BasicPriority Application Country
Priority Application Country, Basic

PN.B
PATS.B
PNC
PNK
PNK.B
PRC
PRC.B

Y (15,29)
Y (15,30)
Y (31)YYY
Y (32)

Y
N
N
Y
Y
Y
Y

Priority Application Date
Priority Application Date, BasicPriority Application Information
Priority Application Information, BasicPriority Application Number
Priority Application Number, BasicPriority Application Year
Priority Application Year, Basic
Publication Date
Publication Date, Basic
Publication Year
Publication Year, Basic
Source of Document
Supplementary Term
Title
Treatment Code

PRD
PRD.B
PRAI
PRAI.B
PRN
PRN.B
PRY
PRY.B
PD
PD.B
PY
PY.B
SO
ST
TI
TC

Y
Y (33)Y (15,34)
Y (15,35)
Y (15)Y (15,36)
Y
Y (37)Y
Y (38)Y
Y (39)YY
Y (default)
Y (40)

Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
N
N
Y
Y

Patent Number, Basic(1) SELECT HIT AN may be used to restrict terms extracted to those that match the search expression used to create the answer set.
(2) Appends /BI to the terms created by SELECT.
(3) (n) may be a single number, range, or a list of numbers separated by a space or comma.
(4) Selects or analyzes cited reference accession number in CAplus and appends /AN to the terms created by SELECT.
(5) Selects or analyzes cited reference accession number in MEDLINE and appends /AN to the terms created by SELECT.
(6) Selects or analyzes cited reference author name and appends /RAU to the terms created by SELECT.
(7) Selects CODEN and appends /ISN to the terms created by SELECT.
(8) Appends /DS to the terms created by SELECT.
(9) Appends /AN to the terms created by SELECT.
(10) Selects or analyzes the CODEN and appends /ISN to the terms created by SELECT.
(11) Selects or analyzes IC, ICA, and ICI and appends /IPC to the terms created by SELECT.
(12) Appends /AC to the terms created by SELECT.
(13) Appends /AD to the terms created by SELECT.
(14) Selects or analyzes Patent Application Number and appends /AP to the terms created by SELECT.
(15) Enter SET PATENT DERWENT at an arrow prompt (=>) to SELECT patent, application, and priority numbers in Derwent format.
(16) Selects or analyzes Basic Patent Application Number and appends /AP to the terms created by SELECT.
(17) Appends /AP to the terms created by SELECT.
(18) Selects or analyzes AP and PRN and appends /APPS to the terms created by SELECT.
(19) Selects or analyzes AP.B and PRN>B and appends /APPS to the terms created by SELECT.
(20) Appends /AY to the terms created by SELECT.
(21) Selects or analyzes country codes from PI and DS and appends /PCS to the terms created by SELECT.
(22) Selects or analyzes country codes from PI.B and DS.B and appends /PCS to the terms created by SELECT.
(23) Appends /PC to the terms created by SELECT.
(24) Appends /CY.CNT to the terms created by SELECT.
(25) Selects or analyzes the Patent Number and appends /PN to the terms created by SELECT.
(26) Selects or analyzes the Basic Patent Number and appends /PN to the terms created by SELECT.
(27) Appends /PK to the terms created by SELECT.
(28) Selects or analyzes the Patent Number and appends /PATS to the terms created by SELECT.
(29) Appends /PN to the terms created by SELECT.
(30) Selects or analyzes the Basic Patent Number and appends /PATS to the terms created by SELECT.
(31) Appends /PN.CNT to the terms created by SELECT.
(32) Appends /PRC to the terms created by SELECT.
(33) Appends /PRD to the terms created by SELECT.
(34) Selects Priority Number and appends /PRN to the terms created by SELECT.
(35) Selects Basic Priority Number and appends /PRN to the terms created by SELECT.
(36) Appends /PRN to the terms created by SELECT.
(37) Appends /PRY to the terms created by SELECT.
(38) Appends /PD to the terms created by SELECT.
February 2016

9
LMARPAT(39) Appends /PY to the terms created by SELECT.
(40) Appends /DT to the terms created by SELECT.

Sample Record
DISPLAY IALLACCESSION NUMBER:
TITLE:INVENTOR(S):PATENT ASSIGNEE(S):
SOURCE:DOCUMENT TYPE:LANGUAGE:
INT. PATENT CLASSIF.:
INITIAL CLASS:RECLASSIFICATION:

CLASSIFICATION:FAMILY ACC. NUM. COUNT:PATENT INFORMATION:

112:36458 LMARPAT Full-text
Preparation of chiral statine analogs via aldol
condensation of acetoxytriarylethanols with amino acidaldehyde derivatives
Devant, Ralf U.; Radunz, Hans Eckart
Merck Patent G.m.b.H., Fed. Rep. Ger.
Ger. Offen., 6 pp.
CODEN: GWXXBXPatentGerman
C07C0101-30 [ICM,4]; C07C0125-065 [ICS,4]; C07D0263-24[ICS,4]
C07C0227-32 [I,A]; C07C0229-22 [I,A]; C07C0229-34[I,A]; C07C0271-22 [I,A]; C07D0263-24 [I,A];
C07D0333-16 [I,A]
34-2 (Amino Acids, Peptides, and Proteins)
1

PATENT NO.
KIND DATEAPPLICATION NO. DATE--------------- ---- ---------------------- -------DE 3743225
A1
19890629
DE 1987-3743225 19871219
PRIORITY APPLN. INFO.:
DE 1987-3743225 19871219
OTHER SOURCE(S):MARPAT 112:36458
ABSTRACT:
Statine derivs. R4CH2CH(NHR3)CH(OR2)CH2CO2R1 [I; R1 = H, C1-5 alkyl; R2 = H,
C1-5 alkyl, COR5; R3 = H, protecting group; R4 = C1-5 alkyl, (substituted) Ph,
cyclohexyl; R5 = C1-5 alkyl], useful as renin inhibitor intermediates, wereprepared enantioselectively by condensation of AcOCHR6CR7R8OH (R6-R8 = C6-10aryl) with R4CH2C(NHR3)CHO followed by hydrolysis and transesterification.
Thus, (S)-2-acetoxy-1,1,2-triphenylethanol in THF at -78° was treatedwith (Me2CH)2NLi, and the mixture was stirred 1 h at 0°, and recooled to-78°. N-tert-Butoxycarbonyl-(S)-phenylalaninal in THF was added and the
mixture was stirred 2 h to give (2S,3S,4S)-(3-hydroxy-4-tertbutyloxycarbonylamino-5-phenylpentanoyloxy)-1,1,2-triphenylethanol (in a 12:1
ratio over the 3R isomer). The latter was stirred with NaOMe in dioxane/MeOH
at 0° to give Me (3S,4S)-3-hydroxy-4-tert-butoxycarbonylamino-5phenylpentanoate.
SUPPL. TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

renin inhibitor intermediate statine analog; amino acidstatine analog prepn; aldol condensation enantioselective
amino acid aldehyde
Aldol condensation(of acetoxytriarylethanol derivs. with amino acidaldehyde derivs.)
Asymmetric synthesis and induction(of statine derivs., via aldol condensation ofacetoxytriarylethanols with amino acid aldehydes)
72155-45-4, N-tert-Butoxycarbonyl-(S)-phenylalaninal
124529-58-4, 2-tert-Butoxycarbonylamino-3-(4methylcyclohexyl)propanal
ROLE: RCT (Reactant); RACT (Reactant or reagent)(aldol condensation of, with acetoxytriphenylethanol)
59830-60-3
ROLE: RCT (Reactant); RACT (Reactant or reagent)(aldol condensation of, with acetoxytriphenylethanol, in
preparation of renin inhibitor intermediate)
95061-51-1, (S)-2-Acetoxy-1,1,2-triphenylethanol
February 2016

10
LMARPATINDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

INDEX TERM:

REFERENCE COUNT:REFERENCE(S):ROLE: RCT (Reactant); RACT (Reactant or reagent)(aldol condensation of, with phenylalaninal)
124529-60-8P
124529-62-0P
ROLE: RCT (Reactant); SPN (Synthetic preparation); PREP
(Preparation); RACT (Reactant or reagent)(preparation and aldol condensation of, with phenylalaninal
derivative, in preparation of intermediate for rennin
inhibitor)
118219-44-6P
124529-59-5P
124529-63-1P
ROLE: RCT (Reactant); SPN (Synthetic preparation); PREP
(Preparation); RACT (Reactant or reagent)(preparation and methanolysis of)
124529-61-9P
ROLE: RCT (Reactant); SPN (Synthetic preparation); PREP
(Preparation); RACT (Reactant or reagent)(preparation and methanolysis of, in preparation of rennin
inhibitor intermediate)123689-40-7P
ROLE: RCT (Reactant); SPN (Synthetic preparation); PREP
(Preparation); RACT (Reactant or reagent)(preparation of, as intermediate for renin inhibitor)
72155-54-5P
101669-80-1P
ROLE: RCT (Reactant); SPN (Synthetic preparation); PREP
(Preparation); RACT (Reactant or reagent)(preparation of, as renin inhibitor intermediate)118219-42-4P
ROLE: SPN (Synthetic preparation); PREP (Preparation)(preparation of, as renin inhibitor intermediate)49642-07-1DP, Statine, derivs.
ROLE: SPN (Synthetic preparation); PREP (Preparation)(preparation of, via aldol condensation of amino acidaldehydes with acetoxytriarylethanols)
2786-07-4, 2-Thienyllithium
ROLE: RCT (Reactant); RACT (Reactant or reagent)(reaction of, with mandelic acid and acetyl chloride)4294-57-9, p-Tolylmagnesium bromide
ROLE: RCT (Reactant); RACT (Reactant or reagent)(reaction of, with methylmandelic acid and acetyl
chloride)75-36-5, Acetyl chloride
ROLE: RCT (Reactant); RACT (Reactant or reagent)(reaction of, with methylmandelic acid and tolylmagnesium
bromide, in preparation of renin inhibitor intermediate)
17199-29-0, S-Mandelic acid
ROLE: RCT (Reactant); RACT (Reactant or reagent)(reaction of, with thienyllithium and acetyl chloride)75172-62-2
ROLE: RCT (Reactant); RACT (Reactant or reagent)(reaction of, with tolylmagnesium bromide and acetyl
chloride, in preparation of renin inhibitor intermediate)
1
THERE ARE 1 CITED REFERENCES AVAILABLE FOR THISRECORD.
(1) Anon; DE 3628650 A1 CAPLUS

MSTR 1

G1
G2
G3= OH / alkoxy <containing 1-5 C>= OH / alkoxy <containing 1-5 C> /alkylcarbonyloxy <containing 1-5 C>= NH2 / 11

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LMARPATG4= alkyl <containing 1-5 C> /Ph (opt. substd. by 1 or more G5) /cyclohexyl (opt. substd. by 1 or more G5)= alkyl <containing 1-4 C> /alkoxy <containing 1-4 C> / halo / OH
= R <"protecting group"> / (Examples: CO2CH2Ph /CO2Bu-t / CH2Ph / 28)

G5
G6

Patent location:

claim 1

MSTR 2

G1= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 11 / thienyl / pyridyl / naphthyl)

G2
G3
G4

= phenylene= halo / Cl / F / OH / Me / OMe / NO2= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 13 / thienyl / pyridyl / naphthyl)

G5= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 15 / thienyl / pyridyl / naphthyl)

G6= phenylene
G7= phenylene
Patent location:

claim 1

MSTR 3

G3= NH2 / 11

G4

= alkyl <containing 1-5 C> /Ph (opt. substd. by 1 or more G5) /cyclohexyl (opt. substd. by 1 or more G5)= alkyl <containing 1-4 C> /alkoxy <containing 1-4 C> / halo / OH
= R <"protecting group"> / (Examples: CO2CH2Ph /CO2Bu-t / CH2Ph / 28)

G5
G6

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LMARPAT

Patent location:

claim 1

MSTR 4

G2
G3

G4

G5
G6

= OH / alkoxy <containing 1-5 C> /alkylcarbonyloxy <containing 1-5 C>= NH2 / 11

= alkyl <containing 1-5 C> /Ph (opt. substd. by 1 or more G5) /cyclohexyl (opt. substd. by 1 or more G5)= alkyl <containing 1-4 C> /alkoxy <containing 1-4 C> / halo / OH
= R <"protecting group"> / (Examples: CO2CH2Ph /CO2Bu-t / CH2Ph / 28)

G7= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 35 / thienyl / pyridyl / naphthyl)

G8= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 37 / thienyl / pyridyl / naphthyl)

G9= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 39 / thienyl / pyridyl / naphthyl)

G10= phenylene
G11= phenylene
G12= phenylene
G13= halo / Cl / F / OH / Me / OMe / NO2
Patent location:
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LMARPATDISPLAY QHIT (SET MPTASSEMBLY ON = SYSTEM DEFAULT)MSTR 1 Assembled

56, 57, 59, 60, 62: opt. substd. by 1 or more G5
Patent location:
claim 1
MSTR 3 Assembled

43, 44, 46, 47, 49: opt. substd. by 1 or more G5
Patent location:
claim 1
MSTR 4 Assembled

66, 67, 69, 70, 72: opt. substd. by 1 or more G5
Patent location:
claim 1DISPLAY QHITEXGMSTR 1 Assembled

56, 57, 59, 60, 62: opt. substd. by 1 or more G5
Additional displayed G-groups:
G1= OH / alkoxy <containing 1-5 C>
G2= OH / alkoxy <containing 1-5 C> /alkylcarbonyloxy <containing 1-5 C>

G3= NH2 / 11

Patent location:

claim 1February 2016

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LMARPATMSTR 3 Assembled

43, 44, 46, 47, 49: opt. substd. by 1 or more G5
Additional displayed G-groups:
G3= NH2 / 11

Patent location:

claim 1

MSTR 4 Assembled

66, 67, 69, 70, 72: opt. substd. by 1 or more G5
Additional displayed G-groups:
G2= OH / alkoxy <containing 1-5 C> /alkylcarbonyloxy <containing 1-5 C>
G3= NH2 / 11

G7

= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 35 / thienyl / pyridyl / naphthyl)

G8= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 37 / thienyl / pyridyl / naphthyl)

G9= aryl <containing 6-10 C> (opt. substd.) /heteroaryl <containing 6-10 C> (opt. substd.) /(Examples: 39 / thienyl / pyridyl / naphthyl)

Patent location:

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