No. DEFC0502

AQUALYTE RS

Date of issue : 26 May 2020
Date of revision : 27 Jun. 2023
Safety Data Sheet

1.

Product and company identification
Product name

: AQUALYTE RSPart No.

: E327337-A, E327337-B

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f2@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical and chemical hazard
Flammable liquids ：Category 2
Human health hazard
Acute toxicity (oral)：Category 4
Acute toxicity (inhalation : vapors)：Category 3
Skin corrosion/irritation：Category 2
Serious eye damage/eye irritation：Category 1
Skin sensitization ：Category 1
Germ cell mutagenicity：Category 2
Carcinogenicity：Category 2

Reproductive toxicity：Category 1BSpecific target organ toxicity (single exposure)：Category 1, Category 3 （anesthetic action）
Specific target organ toxicity (repeated exposure)：Category 1, Category 2－ 1/13 －No. DEFC0502

AQUALYTE RS

Environmental hazard
Aquatic acute：Category 2

Aquatic chronic：Category 2

Pictograms or symbols

Signal word

：Danger

Hazard statements：Highly flammable liquid and vapor
Harmful if swallowed
Toxic if inhaled
Causes skin irritation
Causes serious eye damage
May cause an allergic skin reaction
Suspected of causing genetic defects
Suspected of causing cancer
May damage fertility or the unborn childCauses damage to organs (central nervous system, visualorgans, systemic toxicity, liver. kidney, respiratory organs,cardiovascular)
May cause drowsiness and dizziness
Causes damage to organs (central nervous system, visualorgans, respiratory tract) through prolonged or repeatedexposure
May cause damage to organs (blood, thyroid
gland) through prolonged or repeated exposure
Toxic to aquatic life
Toxic to aquatic life with long lasting effects

Precautionary statements
Prevention：Do not handle until all safety precautions have been read andunderstood.
Keep away from ignition sources such as heat, sparks, or open
flame.
Keep containers tightly closed.
Ground container and receiving equipment in case of transportand stirring.
Use explosion-proof apparatus.
Use only non-sparking tools.
－ 2/13 －No. DEFC0502

AQUALYTE RS

Do not breathe dust, mist, and vapor.
Use only in a well-ventilated area.
Avoid release to the environment.
Do not eat, drink or smoke when using this product.
Contaminated work clothing should not be allowed out of theworkplace.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.
Wash protective equipment thoroughly after use.
Wash hands thoroughly after handling.
Response：If inhaled : Remove victim to fresh air and keep at rest in aposition comfortable for breathing. Immediately get medical
treatment.
If swallowed: Rinse mouth, Get medical treatment if you feelunwell.
If in eyes : Rinse cautiously with water for several minutes.
Get medical treatment.
If on skin : Remove contaminated clothing and the substance.
Immediately get medical treatment.
If exposed, get medical treatment.
Get medical treatment, if you feel unwell.
Collect leakage

Storage：Tightly container closed and store in a well-ventilated area.
Store locked up.

Disposal：Dispose of contents and containers appropriately in accordancewith related regulations.

3.

Composition/Information on ingredients
Distinction of substance or mixture：Mixture
Chemical nameConcentration (%)

Formula

TSCA

EC-No.

CAS RN

Methanol

49

CH3OH

Listed200-659-6

67-56-1

Chloroform

31

CHCl3

Listed200-663-8

67-66-32,2'-Iminodiethanol

10-15(HOCH2CH2)2NH

Listed203-868-0

111-42-2

Sulfur dioxide

5-10

SO2

Listed231-195-2

7446-09-5

Iodine1-5

I2

Listed231-442-4

7553-56-2－ 3/13 －No. DEFC0502

4.

AQUALYTE RSFirst aid measures
Inhalation：Remove the victim to fresh air, and make him blow his noseand gargle.

Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. Get medical treatment.

Ingestion：Rinse mouth with water. Give the victim one or two glasses ofwater or milk, do not induce vomiting. Get medical treatment assoon as possible.

Anticipated acute and delayed symptoms：When the steam of the methanol is inhaled, the cough,headache, dizziness, losing breath, and the evil intention, etc.
might be caused. The symptom might appear delaying.
Protection for first aid person：Savers wear proper protective equipment like rubber gloves,
goggles.

5.

Fire fighting measures
Extinguishing media：Water, dry chemical powder, carbon dioxide, dry sand, alcohol
resistant foam

Prohibited extinguishing media：Foam extinguisher
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be
used for small fires. Alcohol-resistant foam extinguisher iseffective for a large scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures
Cautions for personnel：Wear proper equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind andevacuate people downwind. Shut off all sources of ignition.
－ 4/13 －No. DEFC0502

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Keep away personnel except for authorized ones from spillage
area by stretching ropes.
Cautions for environment：Attention should be given not to cause damage to theenvironment by flowing of spillage to rivers. In case of thedilution of copious water, do not cause damage to theenvironment by untreated wastewater.
Methods and Equipment for Containment and Cleaning up
For containment：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush residual area with copious amounts of water.

Prevention of second accident：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Engineering measures：Wear proper equipment not to contact with skin or inhale thevapor. Fire is strictly prohibited.
Ventilate well at working places.
Prevent build-up of electrostatic charges (e.g. by grounding).
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Cautions：Do not allow contact with oxidizing substances.

Storage
Adequate storage condition：Store in a dark, cool place and tightly closed.
Safety adequate container materials：Glass, fluorine resin, stainless steel
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8.

Exposure control/Personal protection
Methanol

ACGIH TWA：200ppm
ACGIH STEL：250ppm

Chloroform

ACGIH TWA：10ppm

2,2'-Iminodiethanol

ACGIH TWA：1mg/m3

Sulfur dioxide

ACGIH STEL：0.25ppm

IodineACGIH TWA：0.01ppm－ 5/13 －No. DEFC0502

AQUALYTE RSACGIH STEL：0.1ppm
Engineering measures：Use only with adequate ventilation and in closed systems.
Protective equipment
Respiration protective equipment：If necessary, wear chemical cartridge respirator with anorganic vapor cartage
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles
Skin and body protective equipment：Protective clothing, protective boots9.

Physical and chemical properties
Appearance：Liquid

Color：Yellow

Odor：Aromatic odorpH

：No data available

Melting point：No data available

Freezing point：No data available

Boiling point：60 CFlash point：15 C

Auto-ignition temperature：470 C (as methanol)
Decomposition temperature：No data available
Flammability：Flammable

Vapor pressure：212hPa(20℃)(as chloroform)

Relative density：No data available

Density：1.1g/cm3 (20 C)

Relative gas density ：No data available
Solubility：Water：Soluble
Organic solvents：Miscible with many kinds of organic solvents
like ethanol, diethyl ether.

Partition coefficient n-octanol/water (Log Pow)
－ 6/13 －No. DEFC0502

AQUALYTE RS：No data available
Explosive limits (vol %)：5.5 – 26.5 vol %Viscosity, kinematic：No data available

Particle characteristics：No data available

10. Stability and reactivity
Reactivity：React with oxidizing substances.

Chemical stability：Stable under normal usage.

Possibility of hazardous reactions：React with oxidizing substances.
Conditions to avoid：Light, heat

Incompatible materials ：Oxidizing substances
Hazardous decomposition products：Carbon monoxide, Nitrogen oxide, Sulfur oxide, Chlorine,
Hydrogen chloride

11. Toxicological information
Acute toxicity(oral)：Harmful if swallowed(as chloroform)
rat LD50=440mg/kg(as iodine)
Rat LD50=315mg/kg

Acute toxicity(dermal)：No classification(as methanol)
rabbit LD50=15800mg/kg(as iodine)
Rat LD50=3333mg/kg
Acute toxicity(inhalation)
Toxic if inhaled (vapor)(as iodine)
rat inhalation LC50=0.363mg/L/4H (vapor)
Classification not possible (dust, mist)
Skin corrosion/irritation：Causes skin irritation
Chloroform：There is evidence including "in rabbit skin irritation－ 7/13 －No. DEFC0502

AQUALYTE RS

tests in which undiluted chloroform was applied to abdominal
skin for 24 hours, slight hyperemia, moderate necrosis andeschar formation were observed," "after undiluted chloroform
was applied, severe irritation was observed," and "after thesubstance was applied to rabbit ears 1-4 times, slight
hyperemia and excoriation were noted." Thus, the product wasclassified into category 2.
Serious eye damage/eye irritation：Causes serious eye damage
Based on the result of eye irritation tests of chloroform using
rabbits, causes severe eye irritation with mydriasis, keratitis,
and translucent zones in the cornea, and a purulent
haemorrhagic discharge, it was classified into category 1.
Respiratory sensitization：Classification not possible
Skin sensitization：May cause an allergic skin reaction
Iodine is listed in the 2nd skin group of the sensitization
substance of Japan Society for Occupational Health. Thus,
the product was classified into category 1.

Germ cell mutagenicity：Suspected of causing genetic defects
Since chloroform has positive results of body cells in vivo
mutagenicity test (micronuclei, test and chromosome aberrationtest), the classification is set to category 2.
Carcinogenicity：Suspected of causing cancer
Japan Society for Occupational Health classifies chloroform as
the group 2B(The chemical is possibly carcinogenic to humans.).
IARC classifies 2,2'-iminodiethanol as group 2B (possibly
carcinogenic to humans). From the above results, it wasclassified into category 2.

Reproductive toxicity ：May damage fertility or the unborn child
Methanol：In a developmental toxicity test by inhalation
exposure to mice during organogenesis period, fetal resorptions
and exencephaly were observed. Additionally, similar effects
including cleft palate were reported in other inhalation and oral
exposure tests. For effects of methanol on reproduction,scientific decisions concerning health risks are generally basedon what is known as weight-of-evidence approach. Recognizing
the lack of human data and the clear evidence of laboratory－ 8/13 －No. DEFC0502

AQUALYTE RS

animal effects, it was concluded that methanol may adversely
affect human development if exposures are sufficiently high.
Based on the information, the product was considered to be apresumed human reproductive toxicant and it was classified
into category 1B.
Specific target organ toxicity (single exposure)：Cause damage to organs (central nervous system, visual organ,
systematic toxicity, liver. kidney, respiratory organs,cardiovascular)
May cause drowsiness and dizziness
Methanol: The symptoms of acute poisoning from the substanceinclude CNS-depression. Formate accumulates in the blood
during a latency period which leads to metabolic acidosis, visual
impairment or even total blindness, headaches, dizziness, nausea,
vomiting, Kussmaul breathing and coma. In some cases death isthe final outcome. Further, CNS disorders, especiallyparkinsonism-like extrapyramidal symptoms were reported.
Morphological changes, necrosis in the white substance of thebrain were demonstrated. Based on the human information, thesubstance was classified into category 1 (central nervous
system).Additionally, the eye was regarded as a target organ
since visual impairment is a characteristic effect. Additionally,systemic toxicity is regarded as a target organ based on thereports of headache, nausea, vomiting, tachypnea and coma as
signs of metabolic acidosis. The effects of single exposures byinhalation include narcosis. As an acute toxicity in humans, anarcotic effect results from central nervous system depression.
Based on the data, the substance was classified into category
3 (narcotic effects).
Chloroform: The substance was used as an anesthetic in thepast. There is human evidence including "In inhalation exposure,anesthetic actions, cough, giddiness, lethargy, hypesthesia,
headache, nausea, vomiting, abdominal pain, hyposthenia,
unconsciousness, coma, raptus nervorum, tachypnea, respiratory
center paralysis, consciousness disorder, acute respiratory
failure, arrhythmia, cardiovascular system depressant action,
ventricular fibrillation, jaundice, hepatocyte degeneration andnecrosis, renal tubular necrosis and renal failure were noted."and "In oral ingestion, gastralgia, nausea, vomiting, diarrhea,－ 9/13 －No. DEFC0502

AQUALYTE RS

gastrointestinal irritation, respiratory center paralysis, raptus
nervorum, coma, oliguresis, albuminuria, nephropathy, swellingof renal tubules epithelium, hyaline and fatty degeneration,
hepatopathy and hepatocellular necrosis were observed."Thus, the product was classified into category 1 (central
nervous system, visual organ, systematic toxicity, liver, kidney,
respiratory organs, cardiovascular), category 3 (anesthetic
actions), considering the concentration of each ingredient.
Specific target organ toxicity (repeated exposure)：Cause damage to organs (central nervous system, visualorgans, liver, kidney, respiratory organs) through prolonged orrepeated exposure
May cause damage to organs (blood, thyroid gland) throughprolonged or repeated exposure
Methanol: Based on the human evidence including "Marked
symptoms due to long-term exposure to low concentration
methanol were extensive eye damages" and "Occupational
methanol exposure caused loss of eyesight as chronic toxic
effects", it was classified into category 1 (visual organs). And
based on the evidence including "Repeated exposure tomethanol vapor caused headache, dizziness, insomnia andstomach damages as chronic toxic cases", it was classified
into category 1 (central nervous system)..
Chloroform: There is human evidence including "In workers who
were exposed to 14 to 400 ppm (68 to 1,950 mg/m3) of
chloroform for 1 to 6months, progress of hepatitis andsymptoms such as jaundice, nausea and vomiting wereobserved, and onset of hepatitis was also noted at exposure
concentrations of 2 to 205 ppm (9.7 to 1,000 mg/m3)."
There is evidence from animal studies including "In 13-weekoral administration tests by gavage or drinking water
administration in mice, and in 3-week oral administration test
by gavage in rats, within the dose of the guidance value rangeof category 2 (as guidance value:14.8 to 60 mg/kg/day), theeffects on liver (enlargement, degeneration and fatty change ofhepatic cells, early-stage hepatocirrhosis like changes etc.),
kidney (chronic inflammation, degeneration and necrosis ofproximal renal tubule etc.), spleen (atrophy of white pulp,
decreased antibody-forming cell count) were observed." and "In－ 10/13 －No. DEFC0502

AQUALYTE RS

13-week or 2-year inhalation exposure (vapor) tests in rats
and mice, within the concentration range of category 1 (asguidance value: 0.01 to 0.106 mg/L/6 hr/day), the same
histopathology in liver and kidney as above, as well as theeffects on nasal cavity (hypertrophy of bone, atrophy ofolfactory epithelium, metaplasia, acidophilic olfactory epithelium
and respiratory epithelium) were noted."
Since central nervous system and liver from findings on humans
and respiratory organs, liver and kidney from findings on
animals are considered to be target organs, it was classified
into category 1 (central nervous system, kidney, liver,respiratory organs).
Ingestion of iodine in humans causes thyroid disease(hypothyroidism, hyperfunction or thyroiditis). Inhalation of 2,2'iminodiethanol adversely affects respiratory tract, blood, kidney,
and liver. Thus, the product was classified into category 1(central nervous system, visual organs, ｌiver, kidney,
respiratory organs) and category 2 (blood, thyroid gland),considering the concentration of each ingredient.
Aspiration hazard：Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute：Toxic to aquatic life
(as chloroform)
Fish(rainbow trout) LC50=1.24-2.03mg/L/96H

Aquatic chronic：Toxic to aquatic life with long lasting effects

Persistence and degradability：(as methanol) Readily biodegradable BOD：92%(as chloroform) Not readily biodegradable BOD：0%
Bioaccumulative potential：(as methanol) Low bioconcentration log Pow：-0.82(as chloroform) Low bioconcentration BCF：1.4-4.7(1mg/L)、
4.1-13(0.1mg/L)
Mobility in soil：(as methanol) High mobility Koc：2.75(as chloroform) High mobility Koc：34-191

Hazardous to the ozone layer：Classification not possible－ 11/13 －No. DEFC0502

AQUALYTE RS

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Contaminated container and packaging：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)UN No.(IMDG)：1992

Proper shipping name(IMDG)：FLAMMABLE LIQUID, TOXIC, N.O.S.(Methanol, Chloroform,
Solution)
Packing group(IMDG)：ⅡTransport hazard class(es) (IMDG)：3(6.1)
Air transport(IATA)
UN No.(IATA)：1992

Proper shipping name(IATA)：Flammable liquid,toxic, n.o.s.(Methanol, Chloroform, Solution)
Packing group(IATA)：Ⅱ
Transport hazard class(es) (IATA)：3(6.1)Marine pollutant ：Applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category：Y

MFAG-No

：131

15. Regulatory information
Regulatory information with regard to this substance in yourcountry or region should be examined by your own
responsibility.

－ 12/13 －No. DEFC0502

AQUALYTE RS

16. Other information
References
1) Company data on file.
2) NITE Chemical Risk Information Platform (NITE CHRIP), National Institute ofTechnology and Evaluation.
＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,and it does not represent a guarantee the properties of the product. The Safety Data Sheet(SDS) is
prepared based on JIS Z7253.

－ 13/13 －