RTECS® (Registry of Toxic Effects of Chemical Substances)
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Identification of Substances
Toxicity Data
Irritation Data
Federal Standards & Regulations
EPA, NIOSH, NTP, & OSHA Activities

Learning Database

RecordContent• Substance information• Numeric toxicity data
• Standards and regulations

File SizeMore than 191,400 records (8/2019)

Coverage

1971-present

UpdatesQuarterly

Language

English

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Structures

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Mutation Data
Tumorigenic Effects
Reproductive Effects
Toxicology reviews
Other Multiple Dose Data

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RTECS

Sources

Journal Articles, Government Reports, and Unpublished EPA Test Submissions(TSCATS).

User Aids• Online Helps (HELP DIRECTORY lists all help messages available)• Comprehensive Guide to RTECS• STNGUIDE

Clusters• CASRNS• GOVREGS• HEALTH• NUMERIC• SAFETY• TOXICOLOGYSTN Database Clusters information (PDF).

PricingEnter HELP COST at an arrow prompt (=>).

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RTECS

Search and Display Field Codes
Fields that allow left truncation are marked with an asterisk (*).
SearchCode

Search Field Name

Display
Codes

Search Examples

Basic Index * (contains single words
from the chemical name (CN), class
identifier (CI), chemical definition(DEF), irritation data (IRR),
toxicology data (TOX), reproductive
effects data (REP), mutation data(MUT), tumorigenic effects data
(TUM), other multiple dose data
(OMUL), reviews (CREV, TREV),
threshold limit value (TLV), standards
and regulations (SREG), NIOSH
recommendations (NREC), national
occupational survey (SURV), andfederal agency status (ASTA) fields,
as well as RTECS numbers (RTN),
molecular formulas (MF), and CAS
Registry Numbers (RN))

None (or /BI)S POISONOUS
S AROMATIC HYDROCARBON#S ?TOXIC?
S C7H10
S 77772-15-7

ASTA, CI, CN,
CREV, DEF, IRR,
MF, MUT, NREC,OMUL, REP, RN,
RTN, SREG,
SURV, TLV, TOX,
TREV, TUM

Accession Number
Cancer Review (1)

/AN
/CREV

AN
CREV

Cell Type (code and text)/CELL

Chemical Name (2)/CNClass Identifier/CI

Definitions (1)Dose Information (includes dosage
amounts for IRR and MUT) (3,4)

/DEF
/DOSE

Duration (includes duration informationfrom IRR, MUT, OMUL, REP, TOX,
and TUM)
Effect (code and text) (includes effects
from IRR, REP, OMUL, TOX, TUM)
(5)
Element Count (3)/DUR

S 10015/AN
S HUMAN?/CREVS ANIMAL EVIDENCE/CREVS BONE MARROW/CELLS BMR/CELL
S 3-BUTEN-2-OL/CN
S "LEAD ARSENATE (DOT:OSHA)"/CNS HORMONE/CI
S PRIMARY IRRITANT/CIS FERMENT? PRODUCT#/DEF
S 82/DOSE
S 35-40/DOSE (P) MUT/FAS DOSE<=50 (P) MG/IRR
S 10D/DURS 24H/DUR (P) IRR/FA/EFF

S SHOCK/EFF
S H08/EFF

IRR, REP, OMUL,TOX, TUM/Element
Symbol/ASTA

S N>=5
S 2/P
S ASBESTOS/ASTAS SECTION 8/ASTAS CANCER REVIEW/FA
S 24H/DUR (P) IRR/FAS NATURAL?/CI AND DEF/FNA
S 61.05/FW

Not displayed

S 47JMAE/ISN
S JOCEAH/ISN (P) TOX/FAS NTIS?/ISN

ASTA, CREV, IRR,
MUT, NREC,OMUL, REP,
SREG, TLV,
TREV, TOX, TUM
IRR

Federal Agency Status (EPA, NIOSH,
NTP, OSHA) (1)Field Availability
Field not Available
Formula Weight (3)International Standard (Document)
Number (contains CODEN and
NIOSH-assigned codes)

Irritation Data (contains route,organism, dose, duration, and effectinformation) (1)

/FA
/FNA
/FW
(or /MW)
/ISN

/IRR

S EYE#/IRR
S 500 MG/IRR
S EYES (P) HUMAN/IRR

MUT
CN
CI
DEF
IRR, MUT

IRR, MUT, OMUL,REP, TOX, TUM

ASTA
FA
Not displayedFW

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RTECS

Search and Display Field Codes (cont'd)
SearchCode

Search Field Name
Journal Title (6)/JT

S TOXICOLOGY LETTERS/JT

Molecular Formula/MF

Mutation Data (includes system,
organism, route, dose, duration, andcell type information) (1)
National Occupational Survey (1)/MUT

S C16H18N4/MF
S C16 H18 N4/MF
S C16H18N4O2S.2CLH/MF
S LUNG/MUT
S 50 MG L/MUT

NIOSH Recommendations (1)Number of Components (3)Organism (code and text) (includes
organisms from IRR, MUT, OMUL,REP, TOX, and TUM) (5)Other Multiple Dose Data (contains
effect, route, organism, dose, andduration information) (1)Periodic Group
Reproductive Effects Data contains
effect, route, organism, dose, andduration information) (1)Route (includes routes from IRR, MUT,
OMUL, REP, TOX, and TUM) (codeand text) (5)RTECS Entry/Update Date (3)RTECS Number
Source (contains CODEN, NIOSHassigned document codes, andcollation information) (1,6)

/NREC
/NC
/ORGN

/SURV

Display
Codes

Search Examples

ASTA, CREV, IRR,
MUT, NREC,OMUL, REP,
SREG, TLV,
TREV, TOX, TUM
MF

MUT

S 786/SURVS TNF 33/SURVS BENZYL CHLORIDE/NREC
S 4/NCS MOUSE/ORGN
S MUS/ORGN (P) MUT/FA

SURV

/OMUL

S MUSCLE WEAKNESS/OMUL

OMUL

/PG
/REP

S A7/PGS FETUS/REPS 550 MG KG/REP

Not displayed
REP

/RTE

S SKIN/RTE
S ITT/RTE

IRR, MUT, OMUL,REP, TOX, TUM

/DATE
/RTN
/SO

S DATE>=20120700
S DA0184000/RTN
S NTIS/SOS FAATDF 1997/SO
S NTP/SO (P) ASTA/FA

Standards and Regulations (1)/SREG

System (code and text) (5)/SYS

Threshold Limit Value (1)/TLV

Toxicity Data (contains effect, route,organism, dose, and duration
information) (1)Toxicology Review (1)Tumorigenic Data (contains effect,
route, organism, dose, and duration
information) (1)Wiswesser Line Notation/TOX

S AIR(1A)DUST/SREGS DUST IN AIR/SREG
S DNA DAMAGE/SYSS DND/SYS
S 300/TLVS MG 2/TLV
S INHALATION/TOXS FLUID# CHANG?/TOXS (BRAIN (P) HMN)/TOXS TOXICOLOGY REVIEW/TREV
S (CARCINOMA(P)RODENT)/TUM
S 17 G KG/TUM

DATE
RTN
ATSA, CREV, IRR,
MUT, OMUL,NREC, REP,
SREG, TLV, TOX,
TREV, TUM
SREG

/TREV
/TUM

/WLN

S 10SW5SW10/WLN

NREC
Not displayed
IRR, MUT, OMUL,REP, TOX, TUM

MUT
TLV
TOX

TREV
TUM

WLN

(1) Implied (S) proximity is available in this field.
(2) Includes the prime name and synonyms. Foreign names have the language in parentheses after the name, e.g., Cui Xing AN(Chinese). Trade names that are obsolete have (Obs.) following the name, e.g., Textilon (Obs.).
(3) Numeric search field that may be searched with numeric operators or ranges.
(4) Units are not searchable in the /DOSE search field.
(5) EXPAND with codes to see definitions, e.g., E V10/EFF.
(6) Use the FULL display formats, e.g., OMULFULL, to see the full references.

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RTECS

Property Search and Display Field Codes
Property
Search Field Name
Lethal Concentration Fifty, Aerosol(includes data from TOX) (1)Lethal Concentration Fifty, Vapor(includes data from TOX) (1)Lethal Concentration Low, Aerosol(includes data from TOX) (1)Lethal Concentration Low, Vapor(includes data from TOX) (1)Lethal Dose Fifty (includes datafrom TOX) (1)Lethal Dose Low (includes datafrom TOX) (1)Toxic Concentration Low, Aerosol(includes data from OMUL, REP,
TOX, and TUM) (1)Toxic Concentration Low, Vapor(includes data from OMUL, REP,
TOX, and TUM) (1)Toxic Dose Low (includes datafrom OMUL, REP, TOX, andTUM) (1)

Default
Unit

SearchCode

mg/m**3/LC50Appm

SearchExamplesDisplay
Codes
OMUL, TOX

/LC50VS 11+-1/LC50AS LC50A>20 g/m**3
S 175/LC50V

mg/m**3/LCLOAS 65-70/LCLOAOMUL, TOX

ppm

/LCLOVS 10<=LCLOVOMUL, TOX

mg/kg

/LD50

OMUL, TOX

mg/kg

/LDLO

S 2E-03/LD50
S LD50<1 UG/G(P)TOX/FA
S 0.07+-1%/LDLO

mg/m**3/TCLOAS TCLOA>250

OMUL, REP,
TOX, TUM

ppm/TCLOVS 96+-2/TCLOVOMUL, REP,
TOX, TUM

mg/kg

/TDLO

S 14/TDLO

OMUL, REP,
TOX, TUM

OMUL, TOXOMUL, TOX

(1) Numeric search field that may be searched with numeric operators or ranges.

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RTECS

DISPLAY and PRINT Formats
Any combination formats may be used to display or print answers. Multiple codes must be separated by
spaces or commas, e.g., D L1 RN CN STR 4. The fields are displayed or printed in the order requested.
Hit-term highlighting is available in the following display fields: AN, CI, CN (only first name is highlighted),
DATE, DEF, FW, MF, RN, RTN, and WLN. Highlighting must be ON during SEARCH to use the HIT, KWIC,
and OCC formats.
Format
AN
ASTA
CHC
CI
CN
CREV
DATE
DEF
FA (1,2)
FW (MW)
IRR
MF
MUT
NREC
OMUL

REP
RN
RTN
SREG
STF (2)
STR (3)
STS (2,3)
SURV
TLV
TOX
TREV
TUM
WLN
ALL

ASTAFULLBIB
CREVFULLEFFECTSIDE
IRRFULL
LEGAL
MUTFULLOMULFULLQRD (4)REPFULL
August 2019

Content

ExamplesAccession Number
Federal Agency Status for EPA, NIOSH, NTP, and OSHA with source
information
Character CountClass Identifier
Chemical Name
Cancer Review with source information
RTECS Entry/Update Date
Definitions
Field Availability
Formula Weight
Tabular display of irritation data (Route, Organism, Dose, Duration, Effect,
Source)Molecular Formula
Tabular display of mutation data (System, Organism, Cell Type, Route, Dose,
Duration, and Source
NIOSH recommendations with source information
Tabular display of other multiple dose data
(Effect, Route, Organism, Dose, Duration,
Source)Tabular display of reproductive effects data (Effect, Route, Organism, Dose,
Duration, Source)
CAS Registry Number
RTECS Number
Standards and regulations with source information
Flat Structure Diagram (no stereo bonds indicated)
Structure Diagram (includes stereo bonds and R/S/E/Z labels when available)
Stereo Structure (includes stereo bonds when available)
National Occupational Survey (NOHS, NOES) with source information
Threshold Limit Value with source information
Tabular display of toxicity data (Effect, Route, Organism, Dose, Duration,
Source)Toxicology review with source information
Tabular display of tumorigenic data (Effect, Route, Organism, Dose, Duration,
Source)Wiswesser Line Notation

D L4 1-4 AN
D L1 3 ASTA

AN, RN, RTN, MF, FW, CN, DEF, CI, WLN, DATE, CHC, STR, IRRFULL,
MUTFULL, REPFULL, TUMFULL, TOXFULL, OMULFULL, CREVFULL,
TREVFULL, TLVFULL, SREGFULL, NREC, SURV, ASTAFULLASTA with all titles listed under one header
CREV, TREV, TLV
CREV with all sources listed under one header and the complete cancer review
references cited in the sources
IRR, MUT, REP, TUM, TOX, OMULAN, RN, RTN, MF, FW, CN, DEF, CI, WLN, DATE, CHC, STR
IRR and complete irritation data references cited in the sources
SREG, NREC, SURV, ASTA
MUT and complete mutation data references cited in the sources
OMUL and the complete other multiple dose references cited in the sources
IDE and fields containing hit terms. When the hit terms occur in a table, only
the lines containing the hit terms are displayed. (QRD is the default)
REP and the complete reproductive effects references cited in the sources

D L3 2 ALL

D CHC 1,3-5
D CI 5-10
D 1-3,7,8 CN
D CREVD DATE 1-5
D L1 DEF 3
D 1,3,6 FA L5
D FW
D IRR 2
D L8 MF 1-3
D MUT
D NRECD OMULD REP
D RN 4
D RTN 3,4
D SREG
D STF
D 1-10 CN STR
D STS
D SURV 2
D L3 4 TLV
D TOX
D 5,3 TREV
D TUM
D L4 WLN 3

D ASTAFULL
D 1-3,5 BIB
D CREVFULLD EFFECTS 1-10
D IDE
D IRRFULL 1,4
D LEGAL TOTALD MUTFULL
D OMULFULL
D L4 7 QRD
D REPFULL 1-4

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RTECS

DISPLAY and PRINT Formats (cont'd)FormatSREGFULLTLVFULLTOXFULL
TREVFULLTUMFULL
HIT
KWIC
OCC (1)

Content

ExamplesSREG with all sources listed under one heading and the complete standards
and regulations references cited in the sources
TLV with all sources listed under one heading and the complete threshold limit
value references cited in the sources
TOX and the complete toxicity data references cited in the sources
TREV with sources listed under one heading and the complete toxicology
review references cited in the sources
TUM and complete tumorigenic data references cited in the sources

D SREGFULL 2 L4

Fields containing hit terms. When the hit term occurs in a table, only the line
containing the hit term is displayed.
Hit term with 20 words on either side (KeyWord-In-Context)
Number of occurrences of hit terms and fields in which they occur

D HIT

D L7 TLVFULLD TOXFULL 1-3
D TREVFULL
D 3 TUMFULL

D KWIC NOH
D OCC 1-5

(1) No online display fee for this format.
(2) Custom display only.
(3) Stereo structure diagrams are available only on graphics terminals and in offline prints.
(4) Only the first name in the CN field is displayed.

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RTECS

SELECT, ANALYZE, and SORT Fields
The SELECT command is used to create E-numbers or an L-number containing terms from the specified fieldin an answer set.
The ANALYZE command is used to create an L-number containing terms taken from the specified field in ananswer set.
The SORT command is used to rearrange the search results in either alphabetic or numeric order of thespecified field(s).
Field Name
Accession Number
Cancer Review
CAS Registry Number
CAS Registry Number and Chemical Name
Cell TypeChemical NameClass Identifier
Definitions
EffectFederal Agency Status (EPA, NIOSH, NTP, OSHA)
Formula Weight
Journal Title
Molecular Formula
Molecular Weight
National Occupational Survey (NOHS, NOES)NIOSH Recommendations
Occurrence Count of Hit Terms
Organism
Route
RTECS Entry/Update Date
RTECS Number
SourceStandards and Regulations
SystemThreshold Limit Value
Toxicology Review
Wiswesser Line Notation

Field CodeANALYZE/
SELECT (1)

SORT

AN
CREV
RN
CHEM
CELL
CN
NAME
CI
DEF
EFF
ASTA
FW
JT
MF
MW
SURV
NREC
OCC
ORGN
RTE
DATE
RTN
SO
SREG
SYS
TLV
TREV
WLN

Y
Y (2)
Y (3)
Y (3,4)Y (2)Y (5)Y (3,5)
Y
Y (3)
Y (2)
Y (2)
Y
Y (2)
Y (default)
Y
Y (2)
Y (2)
N
Y (2)
Y (2)
Y
Y
Y (2,6)
Y (2)
Y (2)
Y (2)
Y (2)
Y

N
N
Y
N
N
Y
N
N
N
N
N
Y
N
N
Y
N
N
Y
N
N
Y
Y
N
N
N
N
N
Y

(1) HIT may be used to restrict terms extracted to terms that match the search expression used to create the answer set, e.g., SEL HITMF(2) SELECT HIT and ANALYZE HIT are not valid with this field(3) Appends /BI to the terms created by SELECT.
(4) SELECT HIT and ANALYZE HIT are valid only when search term is the first name in the CN field or is a CAS Registry Number.
(5) SELECT HIT and ANALYZE HIT are valid only when search term is the first name.
(6) Selects or analyzes the CODEN with /SO appended to the terms created by SELECT.

August 2019

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RTECS

Sample Records
DISPLAY QRD (Default)

CAS Registry Number (RN):RTECS Number (RTN):
Molecular Formula (MF):
Formula Weight (FW):
Chemical Name (CN):Class Identifier (CI):
Entry/Update Date (DATE):
Character Count:

219959-86-1
RTECS
CY1204700
C17 H13 N3
259.31
Benzenamine, 4-(9H-pyrido(3,4-b)indol-9-yl)Tumorigen; Mutagen
Jul 2012
3684

DISPLAY ALL

CAS Registry Number (RN):RTECS Number (RTN):
Molecular Formula (MF):
Formula Weight (FW):
Chemical Name (CN):Class Identifier (CI):
Entry/Update Date (DATE):
Character Count:

219959-86-1
RTECS
CY1204700
C17 H13 N3
259.31
Benzenamine, 4-(9H-pyrido(3,4-b)indol-9-yl)-;
9-(4'-Aminophenyl)-9H-pyrido(3,4-b)indole;
Aminophenylnorharman
Tumorigen; Mutagen
Jul 2012
3684

MUTATION DATA (MUT):
System| Organism |Cell Type|Route| Dose |Dur.| Source
SYS
|
ORGN
| CELL| RTE | DOSE |DUR |SO==============+===========+=========+=====+======+====+==========
sister|hamster|lung||0.005 |6H |MUREAV
chromatid||||mg/L |(+S9|515,181,20
exchange
|
|
|
|
|)
|02
--------------+-----------+---------+-----+------+----+---------cytogenic|hamster|lung||0.0012|6H |MUREAV
analysis||||5 mg/L|(+S9|515,181,20
|
|
|
|
|)
|02
--------------+-----------+---------+-----+------+----+---------mutation in|Salmonella |||1 mg/L|20M |MUREAV
microorganisms|typhimurium||||(+S9|515,181,20
|
|
|
|
|)
|02
August 2019

10
RTECS
--------------+-----------+---------+-----+------+----+---------mutation in|Salmonella |||1||MUREAVmicroorganisms|typhimurium|||mg/pla||577S,1,200
|
|
|
|te
|
|5
|
|
|
|(+S9) ||--------------+-----------+---------+-----+------+----+---------DNA damage|Mouse||oral |100.8 |12W |CRNGDP||||mg/kg ||24,1985,20
|
|
|
|
|
|03
--------------+-----------+---------+-----+------+----+---------DNA damage|Salmonella |||0.1|2H |MUTAEX|typhimurium|||umol/L|(+S9|21,411,200
|
|
|
|
|)
|6
--------------+-----------+---------+-----+------+----+---------DNA damage|Salmonella |||0.1|3H |MUTAEX|typhimurium|||umol/L||21,411,200
|
|
|
|
|
|6
MUTATION DATA REFERENCES:
MUREAV Mutation Research(Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964CRNGDP Carcinogenesis (London) (Oxford Univ. Press, Pinkhill House, Southfield
Road, Eynsham, Oxford OX8 1JJ, UK) V.11980MUTAEX Mutagenesis (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.11986-

TUMORIGENIC DATA (TUM):
Effect|Route|Organism|
Dose|Duration| Source
EFF| RTE | ORGN |
DOSE
| DUR
|
SO
===========+=====+========+==========+========+==========
V02;L60|oral |rat
|TDLo 16.80|4W-C|CALEDQ|||mg/kg||163,157,20
|
|
|
|
|01
-----------+-----+--------+----------+--------+---------V03;L60;V16|oral |rat
|TDLo 2|
|JTPAE7|||mg/kg||17,1,2004
TUMORIGENIC DATA REFERENCES:
CALEDQ Cancer Letters (Shannon, Ireland)(Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.11975JTPAE7 Journal of Toxicologic Pathology(Nihon Dokusei Byori Gakkai, editor,
3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.11988

TOXICITY DATA (TOX):
Effect|Route|Organism| Dose | Source
EFF| RTE | ORGN | DOSE |SO===========+=====+========+=======+==========|oral |rat
|TDLo 90|TXAPA9|||mg/kg |175,169,20
|
|
|
|01
-----------+-----+--------+-------+---------T01;T02;U01|oral |rat
|TDLo 90|TXAPA9|||mg/kg |175,169,20
|
|
|
|01

August 2019

11
RTECS
TOXICITY DATA REFERENCES:
TXAPA9 Toxicology and Applied Pharmacology
St., Duluth, MN 55802) V.11959-(Academic Press, Inc., 1 E. FirstOTHER MULTIPLE DOSE DATA (OMUL):
Effect|Route|Organism| Dose
|Duration| Source
EFF| RTE | ORGN | DOSE
| DUR
|
SO
===========+=====+========+=========+========+==========
U01|oral |rat
|TDLo 1344|80W-C|CRNGDP|||mg/kg||25,1967,20
|
|
|
|
|04
-----------+-----+--------+---------+--------+---------U01|oral |rat
|TDLo 56 |4W-C|CRNGDP|||mg/kg||25,1967,20
|
|
|
|
|04
-----------+-----+--------+---------+--------+---------K61;L60;Z01|oral |rat
|TDLo 686 |49W-C|CRNGDP|||mg/kg||25,1967,20
|
|
|
|
|04
OTHER MULTIPLE DOSE REFERENCES:CRNGDP Carcinogenesis (London) (Oxford Univ. Press, Pinkhill House, Southfield
Road, Eynsham, Oxford OX8 1JJ, UK) V.11980-

TOXICOLOGY REVIEW (TREV):TOXICOLOGY REVIEWMUREAV 562,19,2004
TOXICOLOGY REVIEWEMMUEG 45,150,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEW REFERENCES:
MUREAV Mutation Research(Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964EMMUEG Environmental and Molecular Mutagenesis
11th St., New York, NY 10003) V.101987-

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CAS
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August 2019