No. DEFC0513

FORMAMIDE DRY F

Date of issue : 3 Jun. 2020
Date of revision : 11 Oct. 2023
Safety Data Sheet

1.

Product and company identification
Product name: Formamide dry FPart No.

: D312137-1

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f2@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical hazards
Corrosive to metals：Category 1
Health hazard
Carcinogenicity：Category 2

Reproductive toxicity：Category 1BSpecific target organ toxicity (single exposure)：Category 3 (narcosis)
Specific target organ toxicity (repeated exposure)：Category 2 (reproductive organs (male))HazardPictogram or symbol

Signal word

：DangerHazard statement：May be corrosive to metals
May cause drowsiness or dizziness
Suspected of causing cancer－ 1/9 －No. DEFC0513

FORMAMIDE DRY F

May damage fertility or the unborn child
May cause damage to organs (reproductive organs (male))through prolonged or repeated exposure
Precautionary statements
Prevention：Do not handle until all safety precautions have been read andunderstood.
Keep only in original container.
Do not breathe mist/vapors.
Use only outdoors or in a well-ventilated area.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.

Response：IF INHALED: Remove person to fresh air and keep comfortablefor breathing.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor if you feel unwell.
Get medical advice/attention if you feel unwell.
Absorb spillage to prevent material-damage.

Storage：Store in a well-ventilated place. Keep container tightly closed.
Store locked up.

Disposal：Dispose of contents/container to hazardous or special waste
collection point, in accordance with local, regional, national
and/or international regulation.

3.

Composition/Information on ingredients
Distinction of substance or mixture：Substance4.

Chemical nameConcentration (%)

FormulaTSCA

EC-No.

CAS RN

Formamide≥ 98.5

HCONH2

Listed200-842-0

75-12-7

First aid measures
Inhalation：Remove the victim to fresh air, and make him blow his noseand gargle.

Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

Ingestion：The chemical is volatile. Do not induce vomiting because it－ 2/9 －No. DEFC0513

FORMAMIDE DRY F

increases the risk of aspiration into the lungs. Get medical
attention immediately. If necessary, rinse mouth with water.
Protection for first aid person：Rescuers should wear proper protective equipment like rubber
gloves, goggles.
Anticipated acute and delayed symptoms：Inhalation causes lethargy, headache, nausea, unconsciousness.

5.

Fire fighting measures
Extinguishing media：Water, dry chemical powder, carbon dioxide, dry sand,alcohol resistant foam

Prohibited extinguishing media：Foam extinguisher
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be
used for small fires. Alcohol-resistant foam extinguisher iseffective for a large scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures
Cautions for personnel：Wear proper protective equipment and avoid contact with skinand inhalation of vapor. Conduct operations from upwind andevacuate people downwind. Remove all sources of ignition.
Keep away personnel except for authorized ones from spillage
area by stretching ropes.
Cautions for environment：Attention should be given not to avoid discharge of spilled
product into rivers and resulting environmental damage. Whendiluting spill with large amounts of water, discharge ofuntreated wastewater into the environment must be avoided.
Removal measure：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush residual area with copious amounts of water.

Prevention of second accident－ 3/9 －No. DEFC0513

FORMAMIDE DRY F：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Technical measures：Wear proper equipment not to contact with skin or inhale thevapor. Pay attention to fire.
Ventilate well at working places.
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Use in well-ventilated areas.
Cautions：Do not contact with oxidizing substances.

Storage
Adequate storage condition：Store the bottle tightly closed in a cool, dark place because
the substance has hygroscopic property.
Safety adequate container materials：Glass, fluorine resin, stainless steel
Do not use polyvinyl chloride resin, polystyrene.

8.

Exposure control/Personal protection
ACGIH TWA

10ppm

Remark（ACGIH）

Skin

Engineering measures：Use only with adequate ventilation and in closed systems.
Protective equipment
Respiration protective equipment：Chemical cartridge respirator with an organic vapor cartage orairline respirator
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles
Skin and body protective equipment：Protective clothing, protective boots9.

Physical and chemical properties－ 4/9 －No. DEFC0513

FORMAMIDE DRY F

Physical state：LiquidColor：ColorlessOdor：Ammonia likepH：Weak alkalinity

Melting point：2.55 C

Freezing point：No data available

Boiling point：210.5 C (Partially disassembled)

Flash point：175 C (C.C.)

Auto-ignition point：more than 500 C

Decomposition point：No data available

Flammability：Flammable

Vapor pressure：0.004 hPa (20 C)

Relative density：No data available

Density：1.133 – 1.138 g/cm3 (20 C)

Relative gas density ：1.6Solubility：Water: Miscible. Organic solvents: Miscible with ethanol,
acetone.

Partition coefficient n-octanol/water (Log Pow)：-1.51
Explosive limit：2.7 - 19vol%

Viscosity, kinematic：3.31 mm²/s (20℃)

Particle characteristics：No data available

10. Stability and reactivity
Reactivity：When hydrolyzed, it becomes ammonium formate, but when it isdehydrated by heating, it becomes formamide again.
Corrodes copper, brass and mild steel.

Chemical stability：Stable under normal conditions. Hygroscopic.

Possibility of hazardous reactions：N, N-dichloromethane produced by reacting with hypochlorousacid is explosive.
Hydrogen cyanide is produced by a powerful dehydrating agent
such as phosphorus pentoxide.
Conditions to avoid：Light, heat, moisture.

Incompatible materials ：Oxidizing substances.
Hazardous decomposition products：Carbon monoxide, nitrogen oxides, hydrogen cyanide.
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FORMAMIDE DRY F

11. Toxicological information
Acute toxicity (oral) ：No classification
rat LD50=3200mg/kg
Acute toxicity (dermal)：No classification
rabbit LD50=6000mg/kg
Acute toxicity (inhalation)：No classification (gas)Classification not possible (vapor)
No classification (mist)
rat LC50>21mg/L/4h
Skin corrosion/irritation：No classification
The substance has been reported to be slightly irritating to skinand eyes.
Serious eye damage/irritation：No classification
In a rabbit eye irritation test (corresponding to OECD TG405),
the overall average scores for 24/48/72 hours were 1.91 forconjunctival redness, 0.44 for edema, and 0.17 for corneal
opacification. Based on the above, it has been reported that
this substance is slightly irritating to the eyes of rabbits.
Respiratory sensitization：Classification not possible
Skin sensitization：Classification not possible

Germ cell mutagenicity：Classification not possible
As for in vivo, it was negative in a dominant lethal test withmice, negative in a micronucleus test with mouse peripheral
blood erythrocytes, and positive in a mouse bone marrow
micronucleus test by intraperitoneal administration. As for invitro, it was negative in bacterial reverse mutation tests.
Micronucleus test findings are conflicting, with multiple oral
doses being negative and single intraperitoneal doses beingpositive. The micronucleus inducibility was unclear due to thelimitations of each test, and it was classified as "classification
not possible" due to lack of data.
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FORMAMIDE DRY F

Carcinogenicity：Suspected of causing cancer
ACGIH classifies it as the group A3 (confirmed animal
carcinogen with unknown relevance to humans).

Reproductive toxicity ：May damage fertility or the unborn child
There is a report that in a continuous breeding study with miceby the oral route, fertility effects were observed at a dose
where parental toxicity. There is a report that in ateratogenicity test with mice by the oral route, skeletal
malformations were observed in fetuses at a dose where nomaternal toxicity was observed. From the above, it wasclassified into category 1B.
Specific target organ toxicity (single exposure)：May cause drowsiness or dizzinessIn a single inhalation exposure test using rats, symptoms of"lethargy, hunchback posture, clear or red eye discharge, rednasal discharge, partially closed eyes, diarrhea, and brownstaining of the lower abdomen" were observed at doses of
14-21 mg/L. It is reported that the symptoms almost
disappeared on the 8th day after exposure. Based on theabove, it was classified into category 3 (narcosis).
Specific target organ toxicity (repeated exposure)：May cause damage to organs (reproductive organs (male))through prolonged or repeated exposure
In a 2-year combined chronic toxicity/carcinogenicity study byoral gavage in rats and mice, hyperplasia of bone marrow inrats, calcification of testicular arteries and sheath of testis andspleen in mice at 80 mg/kg/day. It has been reported that hematopoietic cell proliferation was observed. There is also areport that blood effects were observed at 300 mg/kg/day in
two 90-day repeated dermal administration studies using rats.
Furthermore, in a 2-week repeated inhalation exposure test
using rats, it was reported that platelet count decreased at500ppm or more, and kidney effects and testicular degeneration
were observed at 1500ppm. Based on the above, thesubstance was classified into category 2 (reproductive organs(male)) because effects on testis were observed within thedose range of category 2.
Aspiration hazard：Classification not possible－ 7/9 －No. DEFC0513

FORMAMIDE DRY F

12. Ecological information
Ecotoxicity
Aquatic acute：No classification
Pseudokirchneriella subcapitata ErC50>1000mg/L/72h

Aquatic chronic：No classification
Pseudokirchneriella subcapitata NOEC>10mg/L/72h

Persistence and degradability：Readily biodegradable
BOD：99%Bioaccumulative potential：Low bioconcentrationlog Pow：-1.51
Mobility in soil：High mobility
Koc：3.6Hazardous to the ozone layer：Classification not possible

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Containers：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea (IMDG)
UN-No. (IMDG)：1760

Proper Shipping Name (IMDG)：CORROSIVE LIQUID, N.O.S.
Packing group (IMDG)：III
Transport hazard class(es) (IMDG)：8
Air transport (IATA)
UN-No. (IATA)：1760

Proper Shipping Name (IATA)：Corrosive liquid, n.o.s.
－ 8/9 －No. DEFC0513

FORMAMIDE DRY F

Packing group (IATA)：III
Transport hazard class(es) (IATA)：8
Marine pollutant：Not applicable

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodePollutant category ：YMFAG-No：154

15. Regulatory information
Regulatory information with regard to this substance in yourcountry or region should be examined by your own
responsibility.

16. Other information
References
1) Company data on file (SDS provided by manufacturer)2) NITE Chemical Risk Information Platform (NITE-CHRIP), National Institute ofTechnology and Evaluation.
＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,and it does not represent a guarantee the properties of the product. The Safety Data Sheet (SDS)
is prepared based on JIS Z7253.

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