No. DEFC0501

AQUALYTE RS-A

Date of issue : 25 May. 2020
Date of revision : 27 Jun. 2023
Safety Data Sheet

1.

Product and company identification
Product name

: AQUALYTE RS-A

Part No.

: D327660-A02, D327660-A12

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f2@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical and chemical hazard
Flammable liquids ：Category 2
Human health hazard
Acute toxicity (oral)：Category 4
Acute toxicity (inhalation : vapors)：Category 3
Skin corrosion/irritation：Category 1B
Serious eye damage/eye irritation：Category 1
Skin sensitization ：Category 1
Carcinogenicity：Category 2

Reproductive toxicity：Category 1BSpecific target organ toxicity (single exposure)：Category 1, Category 2, Category 3 （anesthetic action）
Specific target organ toxicity (repeated exposure)：Category 1, Category 2
Environmental hazard
Aquatic acute：Category 2－ 1/12 －No. DEFC0501

AQUALYTE RS-A

Aquatic chronic：Category 2

Pictograms or symbols

Signal word

：Danger

Hazard statements：Highly flammable liquid and vapor
Harmful if swallowed
Toxic if inhaled
Causes severe skin burns and eye damage
Causes serious eye damage
May cause an allergic skin reaction
Suspected of causing cancer
May damage fertility or the unborn childCauses damage to organs (central nervous system, visualorgans, systemic toxicity, liver)May cause damage to organs (kidney, respiratory organs)
May cause drowsiness and dizziness
Causes damage to organs (central nervous system, visualorgans, respiratory tract) through prolonged or repeatedexposure
May cause damage to organs (blood, kidney, liver, thyroid
gland) through prolonged or repeated exposure
Toxic to aquatic life
Toxic to aquatic life with long lasting effects

Precautionary statements
Prevention：Do not handle until all safety precautions have been read andunderstood.
Keep away from ignition sources such as heat, sparks, or open
flame.
Keep containers tightly closed.
Ground container and receiving equipment in case of transportand stirring.
Use explosion-proof apparatus.
Use only non-sparking tools.
Do not breathe dust, mist, and vapor.
Use only in a well-ventilated area.
Avoid release to the environment.
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Do not eat, drink or smoke when using this product.
Contaminated work clothing should not be allowed out of theworkplace.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.
Wash protective equipment thoroughly after use.
Wash hands thoroughly after handling.
Response：If inhaled : Remove victim to fresh air and keep at rest in aposition comfortable for breathing. Immediately get medical
treatment.
If swallowed: Rinse mouth, do not induce vomiting. Immediately
get medical treatment.
If in eyes : Rinse cautiously with water for several minutes.
Get medical treatment.
If on skin : Remove contaminated clothing and the substance.
Immediately get medical treatment.
If exposed, get medical treatment.
Get medical treatment, if you feel unwell.
Collect leakage

Storage：Tightly container closed and store in a well-ventilated area.
Store locked up.

Disposal：Dispose of contents and containers appropriately in accordancewith related regulations.

3.

Composition/Information on ingredients
Distinction of substance or mixture：Mixture
Chemical nameConcentration (%)

Formula

TSCA

EC-No.

CAS RN

Methanol

75

CH3OH

Listed200-659-6

67-56-1

Imidazole

1-5

C 3H 4N 2

Listed206-019-2

288-32-4

2,2'-Iminodiethanol

8-15(HOCH2CH2)2NH

Listed203-868-0

111-42-2

Sulfur dioxide

4-8

SO2

Listed231-195-2

7446-09-5

Iodine1-5

I2

Listed231-442-4

7553-56-2

4.

First aid measures
Inhalation：Remove the victim to fresh air, and make him blow his nose
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AQUALYTE RS-A

and gargle.
Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

Ingestion：Give the victim water immediately and induce vomiting. Get
medical treatment.

Anticipated acute and delayed symptoms：Inhalation of methanol vapor may cause cough, headache,dizziness, breathlessness, and nausea. Symptoms may bedelayed.
Protection for first aid person：Savers wear proper protective equipment like rubber gloves,
goggles.

5.

Fire fighting measures
Extinguishing media：Water, dry chemical powder, carbon dioxide, dry sand, alcohol
resistant foam

Prohibited extinguishing media：Foam extinguisher
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be
used for small fires. Alcohol-resistant foam extinguisher iseffective for a large scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures
Cautions for personnel：Wear proper equipment and avoid contact with skin andinhalation of vapor. Conduct operations from upwind andevacuate people downwind. Shut off all sources of ignition.
Keep away personnel except for authorized ones from spillage
area by stretching ropes.
Cautions for environment：Attention should be given not to cause damage to the－ 4/12 －No. DEFC0501

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environment by flowing of spillage to rivers. In case of thedilution of copious water, do not cause damage to theenvironment by untreated wastewater.
Methods and Equipment for Containment and Cleaning up
For containment：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush residual area with copious amounts of water.

Prevention of second accident：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Engineering measures：Wear proper equipment not to contact with skin or inhale thevapor. Fire is strictly prohibited.
Ventilate well at working places.
Prevent build-up of electrostatic charges (e.g. by grounding).
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Cautions：Do not allow contact with oxidizing substances.

Storage
Adequate storage condition：Store in a dark, cool place and tightly closed.
Safety adequate container materials：Glass, fluorine resin, stainless steel
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8.

Exposure control/Personal protection
Methanol

ACGIH TWA：200ppm
ACGIH STEL：250ppm

Imidazole

Not established2,2'-Iminodiethanol

ACGIH TWA：1mg/m3

Sulfur dioxide

ACGIH STEL：0.25ppm

IodineACGIH TWA：0.01ppm
ACGIH STEL：0.1ppm

Engineering measures：Use only with adequate ventilation and in closed systems.
Protective equipment－ 5/12 －No. DEFC0501

AQUALYTE RS-A

Respiration protective equipment：If necessary, wear chemical cartridge respirator with anorganic vapor cartage
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles
Skin and body protective equipment：Protective clothing, protective boots9.

Physical and chemical properties
Appearance：Liquid

Color：Yellow

Odor：Aromatic odorpH

：No data available

Melting point：No data available

Freezing point：No data available

Boiling point：60 CFlash point：18 C

Auto-ignition temperature：470 C (as methanol)
Decomposition temperature：No data available
Flammability：Flammable

Vapor pressure：128hPa (20 C) (as methanol)

Relative density：No data available

Density：0.93g/cm3 (20 C)

Relative gas density ：No data available
Solubility：Water：Soluble
Organic solvents：Miscible with many kinds of organic solvents
like ethanol, diethyl ether.

Partition coefficient n-octanol/water (Log Pow)
：No data available
Explosive limits (vol %)：5.5 – 26.5 vol %Viscosity, kinematic：No data available

Particle characteristics：No data available－ 6/12 －No. DEFC0501

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10. Stability and reactivity
Reactivity：React with oxidizing substances.

Chemical stability：Stable under normal usage.

Possibility of hazardous reactions：React with oxidizing substances.
Conditions to avoid：Light, heat

Incompatible materials ：Oxidizing substances
Hazardous decomposition products：Carbon monoxide, nitrogen oxides, sulfur oxides, hydrogen iodide

11. Toxicological information
Acute toxicity (oral) ：Harmful if swallowed
Based on animal studies, methanol is considered to be out of
category in Acute toxicity (Oral). However, as methanol shows
strong toxicity in primates, the product was classified into
category 4.
(as methanol)
rat oral LD50=6200mg/kg
Acute toxicity (dermal)：No classification(as methanol)
rabbit skin LD50=15800mg/kg
Acute toxicity (inhalation)：Toxic if inhaled (vapor)(as iodine)
rat inhalation LC50=35ppm/4H
Classification not possible (dust, mist)
Skin corrosion/irritation：Causes severe skin burns and eye damage
Imidazole：In a test in which 0.5mL of paste containing 80%
Imidazole with water was applied to rabbit skin for 4 hours,
severe erythema appeared after one night and lasted until day
8 at the end of observation period, and mild necrosis appeared
after one night and necrosis extending to all layers waspathologically observed at the end of observation period. As aresult, imidazole was judged to be corrosive and was classified
into category 1B. The product was also classified into category－ 7/12 －No. DEFC0501

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1B.
Serious eye damage/eye irritation：Causes serious eye damage (category 1)
Studies with 2,2'-iminodiethanol indicate severe irritation in
rabbits, and redness, a pain, severe burns and caustics inhumans. Thus, the product was classified into category 1.
Respiratory sensitization：Classification not possible
Skin sensitization：May cause an allergic skin reaction
Iodine is listed in the 2nd skin group of the sensitization
substance (substances which probably induce allergic reactions
in humans) of Japan Society for Occupational Health's
recommendation of occupational exposure limits. Thus, theproduct was classified into category 1.

Germ cell mutagenicity：Classification not possible
Methanol gave negative results in micronucleus examinations inmouse erythrocytes. However, the classification is not possible
because there is no data for other ingredients.
Carcinogenicity：Suspected of causing cancer
IARC classifies 2,2'-iminodiethanol as group 2B (possibly
carcinogenic to humans). Thus, the product was classified into
category 2.

Reproductive toxicity ：May damage fertility or the unborn child
Methanol：In a developmental toxicity test by inhalation
exposure to mice during organogenesis period, fetal resorptions
and exencephaly were observed. Additionally, similar effects
including cleft palate were reported in other inhalation and oral
exposure tests. For effects of methanol on reproduction,scientific decisions concerning health risks are generally
based on what is known as weight-of-evidence approach.
Recognizing the lack of human data and the clear evidence oflaboratory animal effects, it was concluded that methanol may
adversely affect human development if exposures are
sufficiently high. Based on the information, the substance wasconsidered to be a presumed human reproductive toxicant andit was classified into category 1B.
Specific target organ toxicity (single exposure)：Cause damage to organs (central nervous system, visual organ,－ 8/12 －No. DEFC0501

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systematic toxicity, liver)May cause damage to organs (kidney, respiratory organs)
May cause drowsiness and dizziness
Methanol：Central nervous system depression and visual organ
disorder were observed by acute oral or inhalation exposure ofmethanol by humans. Metabolic acidosis was observed in humanevidence of exposure. Anesthetic actions were identified by therat, mouse, and Macaca mulatta. Thus, the product wasclassified into category 1 (central nervous system, visualorgans, systemic toxicity) and category 3 (narcotic effects).
2,2'- Iminodiethanol: In orally administered rats, slight damage inhepatic parenchyma cells at 200-1600 mg/kg, large fat
droplets and focal cytoplasmic degradation in hepatic cells at
1600 mg/kg, tubular cell necrosis in kidney at 400 mg/kg andabove, and increases in serum urea, SGOT, and LDH levels at
800 mg/kg were observed. Effects on liver were observed
within the guidance value range of category 1, and effects
on kidney were observed within the guidance value range ofcategory 2. Thus, the product was classified into category 1(liver) and category 2 (kidney).
Moreover, inhalation exposure of rats to 1476 ppm(6.35 mg/L) for 105 minutes (4-hour equivalent: 2.778 mg/L)
caused lethargy, incoordination, and irregular bradypnea
characterized by rales and panting in fatal cases. As
characteristic findings, an increase followed by a decrease inheart rate, severe respiratory distress and an increase insystolic blood pressure were noted. Predominanthistopathological findings was pulmonary edema. Exposure
concentrations fall under category 2 guidance values. Thus,
the product was classified into category 2 (respiratory organs).
Sulfur dioxide: Airway mucosa irritation, increased
airway resistances and respiratory ciliary loss were observedin the inhalation exposure test in guinea pigs, dogs, rabbits, andrats at the concentration of the guidance value range ofcategory 1. Because of the sulfur dioxide concentration, theproduct was classified into category 2 (respiratory organs).
Specific target organ toxicity (repeated exposure)：Cause damage to organs (central nervous system, visualorgans, respiratory tract) through prolonged or repeated－ 9/12 －No. DEFC0501

AQUALYTE RS-A

exposure
May cause damage to organs (blood, kidney, liver, thyroid
gland) through prolonged or repeated exposure
Methanol: Long-term exposure to humans caused central
nervous system depression and visual organ disorder. Thus, theproduct was classified into category 1 (central nervous system,visual organs).
2,2'- Iminodiethanol: In a 3-month inhalation exposure (mist)
test in rats, squamous metaplasia in the larynx at 0.015
mg/L/6h and above, severe inflammation in the pharynx andrespiratory tract at 0.15 mg/L/6h and above were observed,
within the guidance value range of category 1. Thus, theproduct was classified into category 1 (respiratory tract).
Moreover, in the test of drinking water administration to therat for 49 days at 42-550 mg/kg/day, normocytic anemia,
destruction of tubular epithelium cells, dilatation and earlynecrotic changes of the distal tubule with hyaline casts,
hepatocellular cloudy swelling and early degenerative changes
characterized by basophilic loss were seen at 155 mg/kg/day(90-day equivalent: 84.3 mg/kg/day) and above, within theguidance value range of category 2. Thus, the product wasclassified into category 2 (blood, kidney, liver).
Iodine: Oral ingestion in humans caused thyroid desease(hypothyroidism, hyperfunction, or thyroiditis). Thus, the productwas classified into category 2 (thyroid gland).
Aspiration hazard：Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute：Toxic to aquatic life
(as 2,2'-iminodiethanol)
Daphnia pulex LC50=2150μg/L/48H

Aquatic chronic：Harmful to aquatic life with long lasting effects

Persistence and degradability：(as methanol) Readily biodegradable
BOD：92%
Bioaccumulative potential：(as methanol) Low bioconcentration－ 10/12 －No. DEFC0501

AQUALYTE RS-A

log Pow : -0.82
Mobility in soil：(as methanol) High mobility
Koc : 2.75

Hazardous to the ozone layer：Classification not possible

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Contaminated container and packaging：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)
UN-No. (IMDG)：1230

Proper Shipping Name (IMDG)：METHANOL
Packing group (IMDG)：ⅡTransport hazard class(es) (IMDG)：3（6.1）
Air transport(IATA)
UN-No. (IATA)：1230

Proper Shipping Name (IATA)：Methanol
Packing group (IATA)：Ⅱ
Transport hazard class(es) (IATA)：3（6.1）Marine pollutant：Applicable

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Pollutant category ：Y
MFAG-No

：131

15. Regulatory information－ 11/12 －No. DEFC0501

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Regulatory information with regard to this substance in yourcountry or region should be examined by your own
responsibility.

16. Other information
References
1) Company data on file.
2) NITE Chemical Risk Information Platform (NITE CHRIP), National Institute ofTechnology and Evaluation.
＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,and it does not represent a guarantee the properties of the product. The Safety Data Sheet(SDS) is
prepared based on JIS Z7253.

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