No. DEFC0510

DEHYDRATED SOLVENT O

Date of issue : 2 Jun. 2020
Date of revision : 1 Jan. 2021
Safety Data Sheet

1.

Product and company identification
Product name

: DEHYDRATED SOLVENT O

Part No.

: E327340-A, E327340-B

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical and chemical hazard
Flammable liquids ：Category 2
Pyrophoric liquids ：Out of category
Self-heating substances and mixtures：Out of category
Corrosive to metals：Out of category
Human health hazard
Acute toxicity (oral)：Category 4
Acute toxicity (dermal)：Out of category
Acute toxicity (inhalation: vapors)：Category 4
Skin corrosion・Irritation：Category 2
Serious eye damage・Eye irritation：Category 1
Germ cell mutagenicity：Category 2
Carcinogenicity：Category 2－ 1/11 －No. DEFC0510

DEHYDRATED SOLVENT O

Reproductive toxicity：Category 1BSpecific target organ systemic toxicity (single exposure)：Category 1, Category 3 （anesthetic action）
Specific target organ systemic toxicity (repeated exposure)：Category 1
Environmental hazard
Hazardous to the aquatic environment-acute hazard：Category 3
Hazardous to the aquatic environment-chronic hazard：Category 1
Pictogram or symbol

Signal word

：Danger

Hazard statement：Highly flammable liquid and vapor
Harmful if swallowed
Harmful if inhaled
Causes skin irritation
Causes serious eye damage
Suspected of causing genetic defects
Suspected of causing cancer
May damage fertility or the unborn childCauses damage to organs (central nervous system, visualorgans, respiratory organs, cardiovascular, liver, kidneys,
systemic toxicity)
May cause drowsiness and dizziness
Causes damage to organs (central nervous system, visualorgans, kidneys, liver, respiratory organs) through prolonged orrepeated exposureHarmful to aquatic life
Very toxic to aquatic life with long lasting effects

Cautions
Safety measurements：Do not handle until all safety precautions have been read andunderstood.
Keep away from ignition sources such as heat, sparks, or open
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DEHYDRATED SOLVENT O

flame.
Keep containers tightly closed.
Ground container and receiving equipment in case of transportand stirring.
Use explosion-proof apparatus.
Use only non-sparking tools.
Do not breathe dust, mist, and vapor.
Use only in a well-ventilated area.
Avoid release to the environment.
Do not eat, drink or smoke when using this product.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.
Wash protective equipment thoroughly after use.
Wash hands thoroughly after handling.
First-aid measures ：If inhaled : Remove victim to fresh air and keep at rest in aposition comfortable for breathing. Get medical treatment if you
feel unwell.
If swallowed: Rinse mouth, Get medical treatment if you feelunwell.
If in eyes : Rinse cautiously with water for several minutes.
Get medical treatment.
If on skin : Remove contaminated clothing and the substance.
Immediately get medical treatment.
If exposed, get medical treatment.
Get medical treatment, if you feel unwell.
Collect leakage
Storage：Tightly container closed and store in a well-ventilated area.
Store locked up.

Disposal：Dispose of contents and containers appropriately in accordancewith related regulations.

3.

Composition/Information on ingredients
Substance/Mixture：Mixture
Chemical name or commercial name
：Chloroform, Methanol
Ingredients and composition：Mixed solution containing chloroform 55% or more and methanol－ 3/11 －No. DEFC0510

DEHYDRATED SOLVENT O

44% or more.
Chemical formula：Chloroform CHCl3
Methanol CH3OH

CAS No.

：Chloroform 67-66-3
Methanol 67-56-1

EINECS No.

：Chloroform 2006638
Methanol 2006596

Dangerous and hazardous ingredients：Chloroform, Methanol

4.

First aid measures
Inhalation：Remove the victim to fresh air, and make him blow his noseand gargle.

Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

Ingestion：Give the victim water or salt water and make him vomit. Do
not give an unconscious victim anything to drink. Get medical
attention.

Protection for first aid person：Savers wear proper protective equipment like rubber gloves,
goggles.

5.

Fire fighting measures
Extinguishing media：Dry chemical powder, carbon dioxide, dry sand, foam

Prohibited extinguishing media：Water spray
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be
used for small fires. Foam extinguisher is effective for alarge scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures－ 4/11 －No. DEFC0510

DEHYDRATED SOLVENT O

Cautions for personnel：Wear proper equipment and avoid contact with skin andinhalation of vapor. Keep personnel removed from and upwindof fire. Shut off all sources of ignition. Keep away personnel
except for authorized ones from spillage area by stretchingropes.
Cautions for environment：Attention should be given not to cause damage to theenvironment by flowing of spillage to rivers. In case of thedilution of copious water, do not cause damage to theenvironment by untreated wastewater.
Removal measure：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush residual area with copious amounts of water.

Prevention of second accident：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Engineering measures：Wear proper equipment not to contact with skin or inhale thevapor. Fire is strictly prohibited.
Ventilate well at working places.
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Cautions：Do not contact with oxidizing substances.

Storage
Adequate storage condition：Store in a dark, cool place and tightly closed.
Safety adequate container materials：Glass, fluorine resin
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8.

Exposure control/Personal protection
Engineering measures：Use only with adequate ventilation and in closed systems.
Control parameters
ACGIH(2009)：200ppm (as Methanol)(TLV-TWA)－ 5/11 －No. DEFC0510

DEHYDRATED SOLVENT O

250ppm (as Methanol)(TLV-STEL)
10ppm (as Chloroform)(TLV-TWA)
Transdermal absorption
Protective equipment
Respiration protective equipment：If necessary, wear chemical cartridge respirator.
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles

9.

Physical and chemical properties
Appearance：Liquid

Color：Colorless

Odor：Aromatic odor

Boiling point：Not available

Melting point：Not available

Flash point：15.5 C

Auto-ignition point：470 C (as Methanol)

Explosion characteristics
Explosion limit：upper : 36.5vol% lower : 6.0vol% (as Methanol)

Vapor pressure：128hPa (20 C)

Vapor density：2.7

Density：1.03g/cm3 (20 C)

Solubility
Solubility in solvents：Water ; Freely soluble
log Pow：-0.82 (as Methanol)

10. Stability and reactivity
Stability：Stable under normal usage.

Reactivity：React with oxidizing substances.

Incompatible conditions：Light, heat
Incompatible materials ：Oxidizing substances
Hazardous decomposition products：Carbon monoxide, chlorine, hydrogen chloride－ 6/11 －No. DEFC0510

DEHYDRATED SOLVENT O

11. Toxicological information
Acute toxicity：Harmful if swallowed (category 4)
Dermal : Out of category
Harmful if inhaled(vapor)(category 4)
Inhalation (dust, mist) : Not possible to classify because of
insufficient data.
The toxic effects of methanol in primates is more pronounced
than in rodents and a dose of 1400mg/kg was lethal inapproximately half of the cases. Based on the data, it wasclassified into category 4.
(as Methanol)
rat oral LD50=7939mg/kg（as calculated value）
rat inhalation LC50>31500ppm/4H(vapor)rabit skin LD50=15800mg/kg(as Chloroform)
rat oral LD50=635mg/kg
rat inhalation LC50=9636ppm/4H(vapor)rabbit skin LD50=3980mg/kg

Skin corrosiveness：Causes skin irritation(category 2)
In the skin irritation test using rabbits, as a result of a stock
solution of chloroform was applied for 24 hours, there was thereport that mild hyperemia, necrosis and crust formation wereobserved. And is the report that severe irritation was observed
by applied stock solution of chloroform. In addition, as a result
which was applied 1-4 times of this material to the ear of the
rabbit, minor redness and skin peeling was observed. From theabove data, it was classified into category 2.

Irritation to skin, eyes
：Causes serious eye damage(category 1)
Based on the description that as a result of eye irritation testof chloroform using a rabbit, mydriasis, keratitis, semitransparent and pyogenic bleeding like emissions of the cornea
were observed, and causes severe irritation, it was classified in
to category 1.
Respiratory sensitization or Skin sensitization：Respiratory sensitization : Not possible to classify because of
insufficient data.
Skin sensitization : Not possible to classify because of
insufficient data.
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DEHYDRATED SOLVENT O

Although methanol is classified into out of category, it is notpossible to classify because of chloroform has no data.
Mutagenicity：Suspected of causing genetic defects(category 2)
Chloroform is positive in somatic cell in vivo mutagenicity tests(micronucleus and chromosome aberration tests).

Carcinogenic effects ：Suspected of causing cancer(category 2)
Japan Society for Occupational Health classifies chloroform as
the group 2B.(The chemical is propably carcinogenic to humans.)
Effects on the reproductive system：May damage fertility or the unborn child (category 1B)
In a developmental toxicity test of methanol by inhalation
exposure to mice during organogenesis period, fetal resorptions
and exencephaly were observed. Additionally, similar effects
including cleft palate were reported in other inhalation and oral
exposure tests. For effects of methanol on reproduction,scientific decisions concerning health risks are generally basedon what is known as weight-of-evidence approach. Recognizing
the lack of human data and the clear evidence of laboratory
animal effects, it was concluded that methanol may adversely
affect human development if exposures are sufficiently high.
Based on the information, it was considered to be a presumed
human reproductive toxicant, therefore it was classified into
category 1B.
Specific target organ systemic toxicity single exposure：Cause damage to organs (central nervous system, visual organ,
respiratory organs, cardiovascular, liver, kidneys, systemic
toxicity)(category 1)
May cause drowsiness and dizziness(category 3)
In human, there is a history that chloroform has been used as
an anesthetic. By inhalation exposure, there is the descriptionof anesthetic action, cough, dizziness, lethargy, hypoesthesia,
headache, nausea, vomiting, abdominal pain, weakness, loss of
consciousness, coma, seizures, increase respiration, respiratory
center paralysis, impaired consciousness, acute respiratory
failure, arrhythmias, cardiovascular inhibitory action, ventricularfibrillation, jaundice, liver cell degeneration and necrosis, there isa renal tubular necrosis, renal failure.
The symptoms of acute poisoning from methanol include CNSdepression. Formate accumulates in the blood during a latency－ 8/11 －No. DEFC0510

DEHYDRATED SOLVENT O

period which leads to metabolic acidosis, visual impairment oreven total blindness, headaches, dizziness, nausea, vomiting,Kussmaul breathing and coma. In some cases death is the final
outcome. Further, CNS disorders, especially parkinsonism-likeextrapyramidal symptoms were reported. Morphological changes,
necrosis in the white substance of the brain were
demonstrated. Based on the human information, it was classified
into category 1 (central nervous system). Additionally, the eye
was regarded as a target organ since visual impairment is acharacteristic effect. Additionally, systemic toxicity is regarded
as a target organ based on the reports of headache, nausea,
vomiting, tachypnea and coma as signs of metabolic acidosis.
The effects of single exposures by inhalation include narcosis.
As an acute toxicity in humans, a narcotic effect results from
central nervous system depression. Based on the data, it wasclassified into category 3 (narcotic effects).
Specific target organ systemic toxicity repeated exposure：Cause damage to organs (central nervous system, visualorgans, kidneys, liver, respiratory organs) through prolonged orrepeated exposure (category 1)
In human, worker who were exposure for 1-6 months inchloroform, symptoms such as development of hepatitis,
jaundice, nausea, vomiting were observed. There is thedescription that onset of hepatitis causes at exposure
concentration of 2-205ppm (9.7-1,000mg/m3). In experimental
animals, in 13-week forced oral administration test, drinking
water administration test, 3 weeks forced oral administration
to rats, effects on liver (liver swelling of the cell, modified, fat
reduction, such as initial cirrhosis like change), kidney(chronic
inflammation, degeneration of the proximal tubule, necrosis, etc.),
spleen (atrophy of the white pulp, reduction of antibodyproducing cell number) were observed at dose of corresponding
to Category 2(converted guidance value:14.8-60 mg/kg/day).
Based on a report that the most noted health consequence of
longer-term exposure to lower levels of methanol is a broad
range of ocular effects, and that cases of chronic poisoning
from occupational exposure to methanol were manifested bybilateral blindness, From the above results, it was classified into
category 1(central nervous system, visual organs, kidneys,－ 9/11 －No. DEFC0510

DEHYDRATED SOLVENT O

liver, respiratory organs).
Aspiration hazard：Not possible to classify because of insufficient data.

12. Ecological information
Ecotoxicity
Fish toxicity：Harmful to aquatic life(category 3)
Very toxic to aquatic life with long lasting effects(category 1)(as Chloroform)
Chlamydomonas EC50=13.3mg/L/72H
Fish(rainbow trout) NOEC=0.059mg/L/21days

Rediualbility and degradability：Chloroform dose not rapid biodegradability.

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Containers：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
UN class：Class 6.1(Toxic substances) P. G. Ⅱ

UN number：2929

Marine regulation information
UN No.

：2929

Proper shipping name：TOXIC LIQUID, FLAMMABLE, ORGANIC, N.O.S.
Class

：6.1

Sub risk：3

Packing group：Ⅱ

Marine pollutant：P

Aviation regulation information
UN No.

：2929

Proper shipping name
：Toxic liquid, flammable, organic, n.o.s.
Class

：6.1

Sub risk：3

Packing group：Ⅱ－ 10/11 －No. DEFC0510

DEHYDRATED SOLVENT O

15. Regulatory information
Ensure this material in compliance with federal requirements
and ensure conformity to local regulations.

16. Other information
References
1) Company data on file (SDS provided by manufacturer)2) NITE: National Institute of Technology and Evaluation＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,and it does not represent a guarantee the properties of the product. The Safety Data Sheet(SDS) is
prepared based on JIS Z7253, and it has the same required elements on the Material Safety Data
Sheet(MSDS) which is prepared based on JIS Z7250:2010.

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