DKSH611()12:00-12:50

SwitchSENSE:D()

RT-IC

DKSHSwitchSENSE

Dynamic Biosensors

DNA1(Avidity)(Affinity)(Cooperativity)Affinity

Avidity

RT-IC(Real Time Interaction Cytometry-1)

heliX+(SwitchSENSE)

DKSH

heliXcyto(RT-IC)

2024 6 11

12:00-12:50 E

An overview of current microscope andapplication developments in the field of cryo-FIBDr. Rigort AlexanderProduct Marketing Manager, Thermo Fisher ScientificDr. Shintaro MaedaBusiness Development Associate, Thermo Fisher Scientific2017XNMRFIB-SEMFIB-SEM

thermofisher.com/HydraBio140-00024-12-2Email JPTOK.sales-jp@thermofisher.com | TEL 03-3740-0970

F242024 6121150

1240

DSPR(
)Native MSBrukerLC/MSQTOF SNAPII()QTOFMobility Spectrometry: TIMS)(CCS)(1/K0)(Trapped-IontimsTOF

SPR #648x8Dual Prism Sensor ChipSPR

SPR

221-00223-9TEL: 045-440-0471 FAX: 045-453-1827

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E108

Cryptic PocketOpenEye, Cadence Molecular Sciences

MD

Cryptic Pocket

cryptic pocketWeighted Ensemble

WESTPA [1]cryptic pocket

WESTPA

cryptic pocket

OpenEyeOrion®

GTPase KRAScryptic pocket[1] Russo, John D., et al. "WESTPA 2.0: High-performance upgrades for weighted ensemble simulations and analysisof longer-timescale applications." Journal of chemical theory and computation 18.2 (2022): 638-649.
Orion®

OpenEye, Cadence Molecular Sciences222-00332-100-45045-475-7900Learn more at www.cadence.com/openeyeContact: oe_japan@eyesopen.com

CRYO ARMTMFIB/TEMIntroduction of cryo FIB/TEM workflow with CRYO ARMTM cartridge(TEM)3FIBFIB

TEM (FIB/TEM)TEM

FIB

TEM3 mmTEM

FIBPt

CRYO ARMTM

FIB/TEMwww.jeol.co.jp

100-0004

2-1-1

TEL 03-6262-356713

Charge Detection Mass Spectrometry (CD-MS)
ExCELLS(AAV)

5MDa

25nm250

2018

2023

AAV

AAV2024AAV

AAVAAVWatersCD-MS

35kb2

AAV

VP1 VP2VP3DANAAVCD-MSVP

5:5:50

AAV

60

AAV241)

Yamaguchi et al., Glycosylation of recombinant adeno-associated virus serotype 6.Mol. Ther. Meth. Clin Dev. inpress (2024).
2) Ikeda et al., Higher-Order Structure of an Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium ExchangeMass Spectrometry. Viruses 6: 585 (2024).
3) Nishiumi et al., Combined 100 keV cryo-electron microscopy and image analysis methods to characterize the wideradeno-associated viral products. J Pharm Sci. in press (2024).
4) Hirohata et al., Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for theQuantitative Characterization of Adeno-Associated Virus Vectors. Anal. Chem. 96(2):642-651 (2024).
5) Ohnishi et al., Enhancement of recombinant adeno-associated virus activity by improved stoichiometry andhomogeneity of capsid protein assembly. Mol. Ther. Meth.Clin Dev. 31:101142 (2023).
6) Kurinomaru T et al., Optimization of Flow Imaging Microscopy Setting Using Spherical Beads with Optical PropertiesSimilar to Those of Biopharmaceuticals. J Pharm Sci. 112(12):3248-3255 (2023).
7) Maruno T, et al. Size Distribution Analysis of the Adeno-Associated Virus Vector by the c(s) Analysis of BandSedimentation Analytical Ultracentrifugation with Multiwavelength Detection. J Pharm Sci 112(4):937-946 (2023).
8) Takeda K, et al., Critical Calibration of Mass Photometry for Higher-Mass Samples Such as Adeno-Associated VirusVectors. J Pharm Sci. 112(4):1145-1150 (2023).
9) Salama R, et al., Reduction of Recombinant Adeno-Associated Virus Vector Adsorption on Solid Surfaces byPolyionic Hydrophilic Complex Coating. J Pharm Sci. 111(3):663-671 (2022).
10) Oyama H, et al., Characterization of Adeno-Associated Virus Capsid Proteins with Two Types of VP3-RelatedComponents by Capillary Gel Electrophoresis and Mass Spectrometry. Hum. Gene Ther. 32, 1403-1416 (2021).
11) Maruno T, et al., Comprehensive Size Distribution and Composition Analysis of Adeno-Associated Virus Vector byMultiwavelength Sedimentation Velocity Analytical Ultracentrifugation. J. Pharm. Sci. 110, 3375-3384 (2021).

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1. PDBjwwPDBActivity report of PDBj and activity plan of wwPDB()Genji Kurisu, Institute for Protein Research,Osaka University

2.

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