No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

Date of issue : 4 Jun. 2020
Date of revision : 27 Jun. 2023
Safety Data Sheet

1.

Product and company identification
Product name

: AQUALYTE STANDARD WATER-METHANOL SOLUTION
FACTOR 2

Part No.

: D312141-1

Name of manufacturer

2.

: HIRANUMA Co., Ltd.

Address: 1739 Motoyoshida, Mito, Ibaraki, 310-0836, JAPANName of section: Quality assurance department

Telephone number: +81-29-247-7343

Facsimile number: +81-29-240-0381

Mail address: info-f2@hiranuma.com

Summary of danger and Hazard
GHS classification
Physical and chemical hazard
Flammable liquids ：Category 2
Human health hazard
Acute toxicity (oral)：Category 4
Serious eye damage/eye irritation：Category 2A
Reproductive toxicity：Category 1BSpecific target organ toxicity (single exposure)：Category 1, Category 3 （anesthetic action）
Specific target organ toxicity (repeated exposure)：Category 1
Pictograms or symbols

Signal word

：Danger

Hazard statements：Highly flammable liquid and vapor－ 1/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

Harmful if swallowed
Causes serious eye irritation
May damage fertility or the unborn childCauses damage to organs (central nervous system, visualorgans, systemic toxicity)
May cause drowsiness and dizziness
Causes damage to organs (central nervous system, visualorgans) through prolonged or repeated exposure
Precautionary statements
Prevention：Do not handle until all safety precautions have been read andunderstood.
Keep away from ignition sources such as heat, sparks, or openflame.
Keep containers tightly closed.
Ground container and receiving equipment in case of transportand stirring.
Use explosion-proof apparatus.
Use only non-sparking tools.
Do not breathe dust, mist, and vapor.
Use only in a well-ventilated area.
Do not eat, drink or smoke when using this product.
Wear appropriate protective gloves, glasses, clothing, faceshield, or mask.
Wash hands thoroughly after handling.

Response：If inhaled : Remove victim to fresh air and keep at rest in aposition comfortable for breathing. Get medical treatment if you
feel unwell.
If swallowed: Rinse mouth, Get medical treatment if you feelunwell.
If in eyes : Rinse cautiously with water for several minutes.
Get medical treatment.
If on skin : Remove contaminated clothing and the substance.
Get medical treatment, if you feel unwell.
Wash hands thoroughly after handling.
If exposed, get medical treatment.
Get medical treatment, if you feel unwell.

Storage：Tightly container closed and store in a well-ventilated area.
Store locked up.

Disposal：Dispose of contents and containers appropriately in accordance－ 2/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

with related regulations.

3.

Composition/Information on ingredients
Distinction of substance or mixture：Mixture
Chemical nameConcentration

Formula(%)

TSCA

EC-No.

CAS RN

Methanol

99.7

CH3OH

Listed200-659-6

67-56-1

Water

0.3

H 2O

Listed231-791-2

7732-18-5

4.

First aid measures
Inhalation：Remove the victim to fresh air, and make him blow his noseand gargle.

Skin contact：Wash the affected areas under running water.

Eye contact：Wash the affected areas under running water for at least 15
minutes. If necessary, get medical treatment.

Ingestion：Give the victim water or salt water and make him vomit. Do
not give an unconscious victim anything to drink and do not
induce vomiting. Get medical attention.

Anticipated acute and delayed symptoms：Inhalation may cause cough, headache, dizziness, breath
shortness, and nausea, these symptoms may be late todevelop.
Protection for first aid person：Rescuers should wear proper protective equipment like rubber
gloves, goggles.

5.

Fire fighting measures
Extinguishing media：Water, dry chemical powder, carbon dioxide, dry sand, alcohol
resistant foam

Prohibited extinguishing media：Foam extinguisher
Particular fire fighting：Move containers from fire area if it can be done without risk,
if not possible, apply water from a safe distance to cool andprotect surrounding area.
Dry chemical powder, carbon dioxide or dry sand should be－ 3/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

used for small fires. Alcohol-resistant foam extinguisher iseffective for a large scale fire.
Protection for firefighters：Wear breathing apparatus.

6.

Accidental release measures
Cautions for personnel：Wear proper protective equipment and avoid contact with skinand inhalation of vapor. Conduct operations from upwind andevacuate people downwind. Remove all sources of ignition. Keepaway personnel except for authorized ones from spillage areaby stretching ropes.
Cautions for environment：Attention should be given to avoid discharge of spilled productinto rivers and resulting environmental damage. When diluting
spill with large amounts of water, discharge of untreated waste
water into the environment must be avoided.
Methods and Equipment for Containment and Cleaning up
For containment：Absorb spill with inert material (e.g., diatomaceous earth, sand)and flush spillage area with copious amounts of water.

Prevention of second accident：Remove nearby sources of ignition and prepare extinguishingmedia.

7.

Cautions of handling and storage
Handling
Engineering measures：Wear proper equipment to avoid contact with skin or inhalationof vapor. Fire is strictly prohibited.
Ventilate well at working places.
Prevent build-up of electrostatic charges (e.g. by grounding).
Cautions for safety handling：Use with an enclosed system or a local exhaust ventilation.
Use in well-ventilated areas.
Cautions：Do not allow contact with oxidizing substances.

Storage
Adequate storage condition：Store in a dark, cool place and tightly closed.
－ 4/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

Safety adequate container materials：Glass, fluorine resin, stainless steel
Do not use vinyl chloride resin, acrylic resin, polystyrene etc.

8.

Exposure control/Personal protection
Methanol

ACGIH TWA：200ppm
ACGIH STEL：250ppm

Engineering measures：Use with an enclosed system or a local exhaust ventilation.
Protective equipment
Respiration protective equipment：If necessary, wear chemical cartridge respirator with anorganic vapor cartage
Hands protective equipment：Impervious protective gloves
Eyes protective equipment：Safety goggles
Skin and body protective equipment：Protective clothing, protective boots9.

Physical and chemical properties(as methanol)
Appearance：LiquidColor：ColorlessOdor：Aromatic odor

pH：No data available

Melting point：-97.49 C

Freezing point：No data available

Boiling point：64.51 C

Flash point：12 C

Auto-ignition temperature：470 C
Decomposition temperature：No data available
Flammability：FlammableVapor pressure：128hPa (20 C)

Relative density：No data available－ 5/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2Density：0.79g/cm3（20℃）

Relative gas density ：1.1
Solubility：Water：Miscible
Organic solvents：Miscible with many kinds of organic
solvents like ethanol, diethyl ether.

Partition coefficient n-octanol/water (log Pow)：-0.82
Explosive limits (vol %)： 6.0 – 36.5 vol%Viscosity, kinematic：No data available

Particle characteristics：No data available

10. Stability and reactivity
Reactivity：React with oxidizing substances.

Chemical stability：Stable under normal conditions.

Possibility of hazardous reactions：React with oxidizing substances
Conditions to avoid：Light, heat

Incompatible materials ：Oxidizing substances
Hazardous decomposition products：Carbon monoxide

11. Toxicological information
Acute toxicity (oral) ：Harmful if swallowed(as methanol)
rat LD50=6200mg/kg
human LD50=1400mg/kg
As the result of animal experiments, acute oral toxicity isclassified into out of category, however, the toxic effects ofmethanol in primates is more pronounced, therefore it wasclassified into category 4.
Acute toxicity (Dermal)：No classification(as methanol)
rabbit LD50=15800mg/kg
Acute toxicity (Inhalation)：No classification (vapor)－ 6/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2(as methanol)
rat LC50>31500ppm/4H(vapor)
Classification not possible (dust, mist)
Skin corrosion/irritation：Classification not possible
Although there is an unpublished report that when applied tothe skin of rabbits under occlusive conditions for up to20-hour the substance was not irritating, classification was notpossible due to lack of data in a skin irritation test. As
relevant information, although there is a report that application
to rabbit skin for 24-hour under occlusive conditions caused
moderate skin irritation, this irritation was probably a result of
the defatting action of methanol.
Serious eye damage/eye irritation：Causes serious eye irritation
In a rabbit Draize test, mean scores of conjunctivitis were
judged to be 2 and higher (2.1) at 24, 48 and 72-hour after
installation. Chemosis (score of 2.00) observed up to 4-hour
had decreased significantly by 72-hour (score of 0.50). Basedon the data, the substance was classified into category 2A.
Respiratory sensitization：Classification not possible
Skin sensitization：No classification
Based on the description that Methanol has no skinsensitization by maximization test using guinea pig, it was set
into out of category.

Germ cell mutagenicity：Classification not possible
Methanol is negative in mouse erythrocyte micronucleus tests(in vivo somatic cell mutagenicity tests) by inhalation exposureand by intraperitoneal administration.
Carcinogenicity：Classification not possible

Reproductive toxicity ：May damage fertility or the unborn childIn a developmental toxicity test by inhalation exposure to mice
during organogenesis period, fetal resorptions and exencephaly
were observed. Additionally, similar effects including cleft palate
were reported in other inhalation and oral exposure tests.
For effects of methanol on reproduction, scientific decisions
concerning health risks are generally based on what is known－ 7/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

as weight-of-evidence approach. Recognizing the lack of humandata and the clear evidence of laboratory animal effects, it
was concluded that methanol may adversely affect humandevelopment if exposures are sufficiently high. Based on theinformation, the substance was considered to be a presumed
human reproductive toxicant and it was classified into category
1B.
Specific target organ toxicity (single exposure)：Cause damage to organs (central nervous system, visual organ,systematic toxicity)
May cause drowsiness and dizziness
The symptoms of acute poisoning from the substance include
CNS-depression. Formate accumulates in the blood during alatency period which leads to metabolic acidosis, visualimpairment or even total blindness, headaches, dizziness, nausea,vomiting, Kussmaul breathing and coma. In some cases death isthe final outcome. Further, CNS disorders, especiallyparkinsonism-like extrapyramidal symptoms were reported.
Morphological changes, necrosis in the white substance of thebrain were demonstrated. Based on the human information, thesubstance was classified into category 1 (central nervoussystem).
Additionally, the eye was regarded as a target organ sincevisual impairment is a characteristic effect. Additionally,systemic toxicity is regarded as a target organ based on thereports of headache, nausea, vomiting, tachypnea and coma as
signs of metabolic acidosis. The effects of single exposures byinhalation include narcosis. As an acute toxicity in humans, anarcotic effect results from central nervous system depression.
Based on the data, the substance was classified into category
3 (narcotic effects).
Specific target organ toxicity (repeated exposure)：Cause damage to organs (central nervous system, visualorgans) through prolonged or repeated exposure (category 1)
Based on a report that the most noted health consequence of
longer-term exposure to lower levels of methanol is a broad
range of ocular effects, and that cases of chronic poisoning
from occupational exposure to methanol were manifested bybilateral blindness, it was classified into category 1 (visual－ 8/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2organs). Additionally, based on the report that cases of chronic
poisoning from repeated exposure to methanol vapor aremanifested by headache, giddiness, insomnia, and gastricdisturbances, it was classified into category 1 (central nervoussystem).
Aspiration hazard：Classification not possible

12. Ecological information
Ecotoxicity
Aquatic acute：No classification
Crustacea (brine shrimp) LC50=1340mg/L/96H

Aquatic chronic：No classification

Persistence and degradability：Readily biodegradable BOD：92%
Bioaccumulative potential：Low bioconcentration log Pow：-0.82
Mobility in soil：High mobility Koc：2.75

Hazardous to the ozone layer：Classification not possible

13. Disposal consideration
Residual disposal：Burn in a chemical incinerator equipped with an afterburner anda scrubber. Or entrust approved waste disposal companies withthe disposal.

Containers：In case of disposal of empty bottles, dispose bottles after
removing the content thoroughly.

14. Transport information
International Regulations
Transport by sea(IMDG)UN No.(IMDG)：1230

Proper shipping name(IMDG)METHANOL
Packing group(IMDG)：ⅡTransport hazard class(es) (IMDG)：3 (6.1)
Air transport(IATA)－ 9/10 －No. DEFC0518

AQUALYTE TANDARD WATER-METHANOL SOLUTION FACTOR 2

UN No.(IATA)：1230

Proper shipping name(IATA)：Methanol
Packing group(IATA)：Ⅱ
Transport hazard class(es) (IATA)：3 (6.1)
Marine pollutant ：Not applicable
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodePollutant category：YMFAG-No：131

15. Regulatory information
Regulatory information with regard to this substance in yourcountry or region should be examined by your own
responsibility.

16. Other information
References
1) Company data on file2) NITE Chemical Risk Information Platform (NITE CHRIP), National Institute ofTechnology and Evaluation.
＊The information contained herein is based on several references and the present state of ourknowledge. However the SDS does not always cover all information about the product, handle theproduct carefully. The information is intended to ordinary usage, in case of particular handlings,
conduct appropriate safety measurements. The information herein is only provision of information,and it does not represent a guarantee the properties of the product. The Safety Data Sheet(SDS) is
prepared based on JIS Z7253.

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