The 1st International Sport Neuroscience Conference 2019
Moderator: Masahiro Okamoto (University of Tsukuba, Japan)

DAY1 - September 18 Wed.

Speakers

12:45-13:00

Photo Session for Guest Speakers

13:00-13:05

Opening Remarks

13:05-14:00

Prologue

14:00-14:10

Coffee Break

14:10-14:55

Session 1

14:55-15:05

Coffee Break

15:05-15:25

Session 2
Co-sponsored by
WILLDYNAMICS

15:25-16:25

Data Blitz for
Poster Presentation

Chairs

Venue

Takeshi Nishijima(Tokyo Metropolitan University, Japan)

Hideaki Soya

Takeshi Nishijima

Pierre J. Magistretti

Hideaki Soya

Takeshi Sakurai
Shingo Soya

Kazuya Suwabe

All poster presenters

Shingo Soya

(University of Tsukuba, Japan)(KAUST, Saudi Arabia and EPFL,
Switzerland, IBRO’s President)(Tokyo Metropolitan
University, Japan)(University of Tsukuba, Japan)(University of Tsukuba, Japan)(University of Tsukuba, Japan)

16:25-17:15

Poster Session | Coffee Break

17:15-18:45

Session 3
Exercise and
Neurodegenerative
DiseaseIgnacio Torres Aleman(Cajal Institute, Spain)

2F
Convention
Hall 200(University of Tsukuba, Japan)

Tetsuya Shiuchi(Tokushima University, Japan)

Zsolt Radak(University of Physical Education, Hungary)

Chia-Liang Tsai(National Cheng Kung University, Taiwan)

18:45-19:00

Closing Remarks

Junichi Nabekura (NIPS, Japan)

Photo Session
19:30-

Reception / Poster Award Ceremony

DAY2 - September 19 Thu.
9:00-9:50

Session 4
Sports Performanceand Neurorehabilitation

9:50-9:55

Coffee Break

9:55-10:50

Session 5

10:50-10:55

Coffee Break

10:55-11:50

Session 6

Takashi Matsui

1F Restaurant

Speakers

Chairs

Venue

Naznin Virji-Babul

Ryoichi Nagatomi

Kimitaka Nakazawa

Hidefumi Waki

(University of British Columbia, Canada)(University of Tokyo, Japan)(University of Tsukuba, Japan)(Tohoku University, Japan)(Juntendo University, Japan)

Henriette van Praag

Zsolt RadakArt F. Kramer

Hideaki Soya

Maria Llorens-Martin

Hideaki Soya

(Florida Atlantic University, USA)

(Northeasten University, USA)

(University of Physical
Education, Hungary)

2F
Convention
Hall 200(University of Tsukuba, Japan)

Move to 1F Room 102
12:00-13:00

02

Luncheon Seminar(Centro de Biología Molecular“Severo Ochoa”, Spain)(University of Tsukuba, Japan)

1F
Conference
Room 102

Welcome to
the 1st International Sport
Neuroscience Conference
Hideaki Soya
President of ISNC, University of TsukubaOnbehalf of the organizing committee, it is our great
pleasure to welcome you to the 1st InternationalSport Neuroscience Conference and to also welcome you tothe city of Tsukuba. This conference has been planned by thecore members of the Japanese Society of Sport Neuroscience(JSSN), which was inaugurated in 2007 and belongs to theJapanese Society of Physical Fitness and Sports Medicine(JSPFSM), and approved as a satellite meeting of the 10th International Brain Organization (IBRO2019) (Daegu, Sep 2125) with the strong recommendation of IBRO president Pierre
Magistretti. Since the annual meeting of the JSPFSM will also
be held in Tsukuba just before IBRO2019, this conference will
be jointly hosted by JSSN, IBRO2019 and JSPFSM in Tsukuba.
Tsukuba plays an important role as an international
science city with more than 60 national research institutes
as well as a national university (University of Tsukuba). The
University of Tsukuba was founded in 1872 and the faculty ofphysical education was opened in 1878, making it the oldest in
Asia. Dr. Jigoro Kano, the founder of Judo, served for 25 years
as a school principal before building a career at the Universityof Tsukuba. Dr. Kano’s legacy to us is the educational
philosophy that our minds are strengthened through proper
physical training. Thus, the University of Tsukuba is a fitting
place to assemble for this unique international conference.
While nascent, the field of Sport Neuroscience is rapidly
growing worldwide and stands to make a substantial impact
on human health. A growing number of studies have revealed
that our brains are remodeled to become more powerful andefficient with regular exercise habits and sports challenges.
Thus, the mission of the JSSN is to explore how the brain
works and develops, and how it reaps the wide variety of
exercise-induced benefits to cognition, motor control, stressresilience, and high-performance in various people, including
vulnerable individuals such as the elderly, in order to design
tailor-made exercise prescriptions and to help people develop
and maintain healthy exercise habits.
The aim of the conference is to share current topics
both with researchers who are engaged in work related toresearch into exercise and sports that is based on behavioral

neuroscience, cognitive neuroscience and neuro-rehabilitation,
and with those in fields of physiology, biochemistry, healthfitness, and so on. Bringing together talented researchers
in such a wide range of fields provides an opportunity tofocus on many different aspects of the link between brain
health and physical health; for example: How do exercise andsports impact brain functions and health? How does exercise
contribute to reducing neurodegenerative diseases? What role
do brain functions play in exerting human high performance?
In addition, we are proud to bring you a great synergyof expertise from internationally renowned neuroscientists
with several interesting keynote lectures. Further, a datablitz
session among keynote speakers at the midpoint of the
f irst day of meetings will focus on addressing cur rent
achievements associated with future trends and challenges
in scientific research, technology development, and clinicalpractice. Through this conference we will provide a forum for
networking and information exchange that we hope will proveinvaluable to current researchers. It is also an opportunity
for young scientists and students to explore opportunities
for future projects as well as potential for professional
development.
Our committee is comprised of the following members:
Prof. Pierre J. Magistretti (KAUST, EPFL, IBRO’s President),
Prof. Junichi Nabekura (NIPS, President of FAOPS2019),
Prof. Art F. Kramer (Northeastern Univ.), Prof. Henriettevan Praag (Florida Atlantic Univ.), Prof. Ryoichi Nagatomi(Tohoku Univ.), Prof. Hidefumi Waki (Juntendo Univ.), Prof.
Ignacio Torres Aleman (Cajal Institute), Prof. Michael Yassa(UC-Irvine), Prof. Zsolt Radak (Univ. of Phys. Edu. Hungary),Dr. Maria Llorens-Martín (Univ. of Autonoma), Assoc. Prof.
Takeshi Nishijima (Tokyo Metropolitan Univ.), Assoc. Prof.
Tetsuya Shiuchi (Tokushima Univ.), Dr. Kazuya Suwabe, Dr.
Genta Ochi, Assist. Prof. Masahiro Okamoto, Assist. Prof.
Takashi Matsui and Prof. Hideaki Soya (Univ. of Tsukuba). We
would like to thank our community supporters and advocatesas well as our hard-working staff and students who have madethis meeting possible. Welcome to the conference!

International Sport Neuroscience Conference 201903

Prologue

Hideaki Soya, Ph.D.
Director, Advanced Research Initiative for Human High Performance (ARIHHP)
Faculty of Health & Sport Sciences, University of Tsukuba, Japan

Promotion of Brain Fitness with Mild
Enjoyable Exercise: Translational Research
Plato wrote, “In order for man to succeed in life, God provided him
with two means, education and physical activity. Not separately
one for the soul and the other for the body, but for the two together.
With these two means, men can attain perfection” (Plato, 4th century B.C.).
Recent neuroscience research shows that for optimal physicaland mental performance, exercise is essential. Since benefits
induced by daily exercise habits are known to extend to the brain,
where neurons and their networks can be remodeled, such habits
result in improved mental health and physical performance.
Take, for example, the hippocampus, a region that is
responsible for the formation of memories. Aerobic physicalactivity (APA) can enhance the for mation of new neurons(neurogenesis), in the dentate gyrus in the hippocampus (van Praag,2008 etc.). Thus, APA can lead to an increase in the size of the
hippocampus, as it does with muscle tissue, and also to improved
memory (Erickson and Kramer et al., 2011). This is also the casefor most of the prefrontal cortex, which is responsible for executivefunctions. Furthermore, aerobic fitness is associated with memory
and executive function (Erickson et al, 2009; Suwabe et al., 2017;
Colcombe et al., 2004; Hyodo et al., 2016). The close relationshipbetween cardiovascular functions and cognition is thought to beimportant in terms of evolutionary advantage of Homo sapiens(Lieberman, 2013). The reason for this remains uncertain, although
there is a hypothetical relationship for an evolutionary model
linking APA and brain size in human, where selection acting to
improve APA performance through enhanced metabolic regulationand oxygen transport alters baseline neurotrophic and growthfactor signaling (Raichlen and Polk, 2013). Thus, Plato’s words ringtrue: a healthy body and healthy mind are undeniably linked.
Mental health is a decisive factor in determining our qualityof life, and exercise has a positive effect on mental health because
it acts on the brain. Exercise impacts stress-related diseases suchas depression, neurodegenerative disorders such as dementia, andinactivity-related diseases such as diabetes and obesity. Inactivity
leads to an overall weakening of our bodies and minds: this is a
global issue that must be addressed. In Japan, escalating healthcare
costs recently reached a new high, and many people, including alarge number of children, suffer from depression and obesity, often
combined with reduced physical fitness. Finding ways to improveadherence to exercise is an urgent issue. But it’s hard to maintainmotivation with vague promises of future health benefits that are
years away.
Fortunately, in many countries, several forms of bodywork
such as yoga and tai chi, in which people meditate deeply andbecome aware of their posture and breathing, are used in daily
life. However, there is still very little data for the effects of mild
exercise and bodywork. While the ACSM (American College ofSports Medicine) guidelines for exercise prescription define bothvery light and light intensity exercise, empirical exploration of their

04

International Sport Neuroscience Conference 2019beneficial effects is still limited, and most known exercise benefits
result from moderate-intensity exercise.
To address this, we’ve been doing translational research,called the “Brain Fitness” project, which aims to explore exercise
conditions that enhance endurance, cognition, and motivation. We
developed animal and human exercise models based on lactate
threshold level (a physiological measure) and found positive effectsof acute mild exercise on brain loci including the prefrontal cortex
in human (Byun et al., Neuroimage, 2014), and the hippocampus
in human (Suwabe et al., PNAS, 2018) and animals (Soya et al.,
NRS, 2007). Chronic mild exercise regimens resulted in improved
executive functions and spatial memory, respectively. Such beneficial
effects were greater in subjects with higher endurance, which
opened the possibility that endurance capacity is an important factor
in improving cognitive function through exercise that might involvecertain factors acting on brain and brawn simultaneously. Thus, we
explored two types of exercise regimens, mild and high-intensity
interval, which not only improved endurance, but also enhanced
hippocampus-dependent neurogenesis and memory, warranting
further mechanistic studies. Interestingly, brain dopaminergic
regulation increased with both regimens. Furthermore, a wholegenome hippocampal array study revealed some crucial molecularalterations with both regimens (e.g., upregulated APOE and IGF2,
and downregulated TNF) (Inoue et al., Plos One, 2015). Therefore,
any regimen which is meant to induce cognitive functions may
require some level of endurance, as well as anti-inf lammatory
benefits and motivation factors. Exploration of such factors shallprovide new insight into mechanisms by which exercise enhancescognitive functions and mitigates cognitive decline.
During this conference, we will share some of our current
studies showing the cognition-enhancing role of ver y mild
exercise on the brain, especially on the hippocampus (animals andhuman) and the prefrontal cortex (human). Our current findings
show that even mild exercise activates the lateral prefrontal
cortex (Byun et al., Neuroimage, 2014.) and hippocampus (Soya,
BBRC, 2007; Suwabe et al., PNAS, 2018), which in turn improvescognitive functions such as memory and executive functions.
Brain-genic androgen (Okamoto et al., 2012, PNAS) and lipids
and inflammatory factors (Inoue et al., Plos One, 2015), together
with bloodborne insulin-like growth factor (IGF-I) (Nishijima
et al., Neuron, 2010) are thought to play an important role in thedevelopment of enhanced cognition. One especially interesting
f inding is the synergistically benef icial effects associatedwith brain-genic leptin when mild exercise is combined withastaxanthin, a natural pigment used as a supplement (Yook et al,
PNAS, 2019).
We would be delighted if these research were to give rise to aboom in mild exercise such as body work, and, thus, in some small
way serve to improve overall health both in Japan and throughout
the world.

Session 1

Pierre J. Magistretti, Ph.D.
Division of Biological and Environmental Sciences and Engineering, KAUST, Saudi Arabia
Department of Psychiatry, University of Lausanne Medical School, Switzerland

Neuron-Glia metabolic coupling mediatedby lactate: role in neuronal plasticity,
neuroprotection and neuropsychiatric diseases
A tight metabolic coupling between astrocytes and neurons is a
key feature of brain energy metabolism (Magistretti and Allaman, Neuron, 2015). Over the years we have described two basic
mechanisms of neurometabolic coupling. First the glycogenolytic
effect of VIP and of noradrenaline indicating a regulation of brain
homeostasis by neurotransmitters acting on astrocytes, as glycogenis exclusively localized in these cells. Second, the glutamate-stimulated aerobic glycolysis in astrocytes. Both the VIP-and noradrenaline-induced glycogenolysis and the glutamate-stimulated aerobic
glycolysis result in the release of lactate from astrocytes as an energy substrate for neurons (Magistretti and Allaman, Neuron, 2015;
Magistretti and Allaman, Nat Neurosci Rev, 2018; Cali et al., Front
Cell Neurosci, 2019)).
We have subsequently shown that lactate is necessary not only
as an energy substrate but also as a signaling molecule for longterm memory consolidation and for maintenance of LTP (Suzuki etal, Cell, 2011). At the molecular level we have found that L-lactate
stimulates the expression of synaptic plasticity-related genes suchas Arc, Zif268 and BDNF through a mechanism involving NMDA
receptor activity and its downstream signaling cascade Erk1/2 (Yanget al, PNAS, 2014). A transcriptome analysis in cortical neurons
has shown that the expression of a total of 20 genes is modulated by
L-Lactate; of these, 16 involved in plasticity and neuroprotection
are upregulated and 4 involved in cell death are downregulated(Margineanu et al. Front. Mol Neurosci, 2018). This set of results
reveal a novel action of L-lactate as a signaling molecule inaddition to its role as an energy substrate (Magistretti and Allaman,
Nat Neurosci Rev, 2018).
These actions of L-Lactate are also relevant for animal modelsof neuropsychiatric disorders. Indeed we have shown that peripheral
administration of lactate exerts antidepressant-like effects in three
animal models of depression, Forced Swim test, Open Space
Forced Swim Test and chronic corticosterone administration. Thesebehavioral effects of L-Lactate administration are accompanied bychanges in the expression of genes that have been involved in mooddisorders (Carrard et al, Mol.Psy., 2016).
Fi nally, we have also show n neu roprotect ive ef fect sof L-Lactate in vivo in a model of st roke and in vit ro on
excitotoxicity(Berthet et al, Cerebrovasc. Dis, 2012; Jourdain et al,
Sci Reports, 2018) .

Session 2: Co-sponsored by WILLDYNAMICS

Takeshi Sakurai, Ph.D. /Shingo Soya, Ph.D.
International Institute of Integrative Sleep Medicine, University of Tsukuba, Japan

Deciphering the neural mechanism of‘willpower’ that motivates voluntary
wheel running
To live a creative and active life, it is essential to keep high willpower: an ability to try to overcome difficulties and challenges toachieve goals. However, the biological mechanism Although the reward system, executive function controlled by the prefrontal cortex
may be involved, the biological machinery to generate willpower,a unique function of human, has been largely unknown. This research area “Willdynamics” aims to uncover the mechanism of thismental function, and the impact of social/internal environment on
willpower.
Orexins, a critical factor in stabilization of sleep/wakefulness
state, has been involved in motivated behavior (Sakurai et al.,2014). However, it is still unknown about how the neural circuit
controlling arousal is also involved in “willpower”. We focused on
the role of orexin 1 receptor (OX1R) in voluntary wheel runningand found that OX1R deficient mice showed significant decreaseof wheel running activity. Intraperitoneal injection of OX1R
antagonist (SB334867) to the WT mice also showed significant
decrease of voluntary wheel running for several hours. To identify

the downstream effector to regulate voluntary wheel running
via OX1R signaling, we used OX1R floxed (Ox1rloxp/loxp) micemated with different Cre driver mice to generate cell-type selective
knockout mice. Specific deletion of OX1R in the dopaminergic (DA)neurons using DAT-Cre mice (Ox1rloxp/loxp; DAT-Cre) showedsignificant decrease of voluntary wheel running, although thesemice showed comparable basal locomotor activity with controls.
Moreover, acute optogenetic stimulation of DA neurons in the
VTA recovered the amount of wheel running activity in Ox1rloxp/
loxp; DAT-Cre mice. These results suggest that the excitatorytransmission via OX1R in the DA neurons might be importantto generate “willpower” for voluntary wheel running. Selective
deletion of OX1R in the noradrenergic (NA) neurons (Ox1rloxp/
loxp; NAT-Cre mice), or serotonergic (5-HT) neurons (Ox1rloxp/
loxp; ePET-Cre mice) also showed significant decrease of wheel
running and basal locomotor activity. We are continuing to explore
the mechanism by which these monoaminergic systems contributeto the voluntary wheel running activity.

International Sport Neuroscience Conference 201905

Session 2: Data Blitz for Poster Presentation
No

Title

Presenter

Affiliation

01

Analysis of gait motion change by intervention using robot suit HAL
in acute and chronic stage myelopathy patients decompression surgery

Seioh Ezaki

Department of Orthopaedic Surgery, Faculty of
Medicine, University of Tsukuba

02

Modulated muscle control during walking with hybrid assistive limb
(HAL) in a patient with severe spinal cord disorder

Hideki Kadone

Center for Innovative Medicine and Engineering,
University of Tsukuba Hospital, Tsukuba, Japan

03

Robotic intervention alters muscle coordination in acute post-stroke
patients

Chun Kwang Tan

Center for Innovative Medicine and Engineering,
University of Tsukuba Hospital, Tsukuba, Japan04

Effects of lumbar support exoskeleton on muscle coordination in
healthy people

Chun Kwang Tan

Center for Innovative Medicine and Engineering,
University of Tsukuba Hospital, Tsukuba, Japan05

Upper Limb Triggered HAL method: Novel gait training methods forpatients with complete Quadri/Paraplegia due to chronic spinal cord
injuries

Yukiyo Shimizu

Department of Rehabititation Medicine, Universityof Tsukuba Hospital

06

Elbow extension-flexion training using single joint HAL for patientswith spastic cerebral palsy

Yukiyo Shimizu

Department of Rehabititation Medicine, Universityof Tsukuba Hospital07

The relationship between higher coincident-timing task performanceand eye movement in baseball players

Tochikura I.

Field of Health and Sports, Niigata University of
Health and Welfare, Japan08

Effects of electrical muscle stimulation on cognitive performance andcerebral blood flow

Takagi Y.
*Travel Award

The University of Electro-Communications

09

Sympathetic nervous system activity during electrical muscle
stimulation and voluntary exercise

Kitajima D.

The University of Electro-Communications

10

Table Tennis Players Have Superior Motion Vision in Peripheral
VisionRyoma Goya

Graduate School of Frontier of Bioscience, Osaka
University

11

The functional roles of eye movement in the continuous visuomotor
actionChisa Aoyama

Grad. Sch. of Med. Osaka Univ., Osaka, Japan12

The effects of acute exercise on the formation process of visual
perception

Takaaki Komiyama

Center for Education in Liberal Arts and Science,
Osaka University, Osaka, Japan13

The effects of visual exposure during exercise on visual contrast
sensitivity

Kurata Ryo

Graduate School of Frontier Biosciences, Osaka
University

14

Effects of saccadic eye training on the continuous visuomotor action

Taiga Mizumori

Grad. Sch. of Frontier Biosci. Osaka Univ.

15

JUDO a Gentle-Way to Smarter Brain -The Effect of JUDO-based
exercise program on physical fitness and cognitive function in older
people (+65)

Sylwester Kujach*Travel Award

Department of Physiology, Gdansk University ofPhysical Education and Sport, Gdansk, Poland

16

The effects of long-term resistance and aerobic exercise interventions
on neurocognition and neuroprotective growth factors in the elderlywith memory problems

Yu-Ju Chen

Institute of Physical Education, Health and LeisureStudies, National Cheng Kung University, Taiwan

17

Purine nucleotide salvage pathway: the effect of short term highintensity interval training at the different times

Rouhollah Haghshenas
Gatabi

Department of Exercise Physiology Faculty ofPhysical Education, University of Mazandaran18

The effects of Virtual Reality Environment on Physiological and
Behavioural Responses to Road Cycling

Nurul Farha Zainuddin

School of Biomedical Engineering and Health
Sciences, Faculty of Engineering, Universiti
Teknologi Malaysia, Johor, Malaysia

19

The effects of daily physical activity and acute moderate exercise on
human dopaminergic system: A preliminary study with spontaneouseye blink rate

Ryuta Kuwamizu*Travel Award

Exercise Biochem. & Neuroendocrinol., Univ.
Tsukuba, Ibaraki, Japan

20

Relationship between aerobic fitness and functional connectivity
during working memory task in older adults: functional near infrared
spectroscopy study

Kazuki Hyodo

Physical fitness institute, Meiji Yasuda LifeFoundation of Health and Welfare, Tokyo, Japan

21

What is the factor which modulate the combined effect of upper bodydance-like movement and groove rhythm on executive function?

T. Fukuie

Laboratory of Exercise Biochemistry and
Neuroendocrinology, University of Tsukuba, Japan

22

Translating and verifying pediatric acute cognitive dysfunction
syndrome “delirium” assessment scale

Yujiro Matsuishi

University of Tsukuba, Doctoral programin Clinical Sciences-Graduate School ofComprehensive Human Sciences, Tsukuba, Japan

23

Sustainable resistance exercise mode to improve cognitive function

Keigo Tomoo

Faculty of Sport and Health Science, Ritsumeikan
University, Kusatsu, Shiga, Japan

24

Sustainable aerobic exercise mode to improve executive function

Takeshi Sugimoto

Faculty of Sport and Health Science, Ritsumeikan
University, Kusatsu, Shiga, Japan

25

Science and culture: Krok-Kradeuang, a new exercise equipment for all

Akkaranee Timinkul

Bachelor of Thai Traditional Medicine Program,
UdonThani Rajabhat University, Thailand

06

International Sport Neuroscience Conference 2019

Session 2: Data Blitz for Poster Presentation
No

Title

Presenter

Affiliation

26

Roles played by midbrain neurons projecting to the ventral medulla ingenerating central command function

Satoshi Koba

Division of Integrative Physiology, Tottori
University Faculty of Medicine

27

Neural maturation enhanced by exercise-induced extracellular vesicles

Hyo Youl Moon

Seoul National University

28

Exercise-induced increment of corticosterone is essential for exerciseenhanced adult hippocampal neurogenesis

Sheng-Feng Tsai
*Travel Award

Department of Cell Biology and Anatomy, Instituteof Basic Medical Sciences, College of Medicine,National Cheng Kung University, Tainan, Taiwan

29

Exercise inhibits microglial activation by increasing circulating
extracellular vesicles

Sheng-Feng Tsai

Department of Cell Biology and Anatomy, Instituteof Basic Medical Sciences, College of Medicine,National Cheng Kung University, Tainan, Taiwan

30

Exercise combined with low-level GABAA receptor inhibition
modulates the expression of neurotrophinsin the cerebellum

Hiroshi Maejima

Department of Rehabilitation Science, Faculty of
Health Sciences, Hokkaido University, Japan

31

Treadmill exercise beneficially contributes to gene expressions relating
to synaptic and axonal plasticity in the motor cortex after ischemic
stroke in rats

Takahiro Inoue*Travel Award

Graduate School of Health Sciences, Hokkaido
University

32

The effects of treadmill exercise in acute stage after stroke on memory
function in a novel rat model of vascular dementia

Naoyuki Himi

Dept Physiol2, Kawasaki Med Sch, Okayama,
Japan

33

Modulatory effects of serotonin on the contrast sensitivity of rats andthe visual responses of V1 neurons corresponding to the performanceof a visual detection task

Akinori Sato

Laboratory of Brain Information Science in Sports,
Grad Sch Frontier Biosci, Osaka Univ, Osaka,
Japan

34

Effect of endurance training with and without Magnolia-officinalis
extract on nesfatin-1, glucose, glycogen, and ATP levels of
hypothalamus and plasma in male rats

Abbas Ghanbari Niaki

Department of Exercise Physiology Faculty ofPhysical Education, University of Mazandaran

35

Role of the amygdala and claustrum in cardiovascular control duringhigh-intensity treadmill exercise in rats

Ko Yamanaka

Department of Physiology, Health and Sports
Science, Juntendo University, Japan

36

Specific changing patterns of arterial pressure during high intensity oftreadmill exercise in rats

Kei Tsukioka

Grduate School of Health and Sports Science,
Juntendo University,

37

Vitamin B1 analog decreases sleep periods and increases physicalactivity in rats

François Grenier

Exercise Biochem. & Neuroendocrinol., Univ.
Tsukuba, Ibaraki, Japan38

Hippocampal leptin mediates synergistic benefits of mild exercise by
an antioxidant on neurogenesis and memory

Jang Soo Yook
*Travel Award

Center for Functional Connectomics, Korea
Institute of Science and Technology, Seoul, Korea

39

Mild exercise activates astrocyte-neuron lactate shuttle in the
hippocampus: A role of dopamine

Takashi Matsui*Travel Award

Sport Neuroscience Division, ARIHHP, Universityof Tsukuba, Japan40

Mild exercise regimen from pre-diabetic stage prevents the onset oftype 2 diabetes and its related hippocampal memory dysfunction

Subrina Jesmin

Laboratory of Exercise Biochemistry and
Neuroendocrinology, Faculty of Health and Sport
Sciences, University of Tsukuba, Japan

41

Mild, rather than intense, exercise during adolescence attenuates
abnormal behavior in prenatal phencyclidine-treated mice

Hikaru Koizumi*Travel Award

Laboratory of Exercise Biochemistry and
Neuroendocrinology, Faculty of Health and Sport
Sciences, University of Tsukuba, Japan

42

Running exercise-induced stress response is cooperatively regulated
by hypothalamus AVP and CRH: anatomical and pharmacologicalapproaches

Kanako Takahashi*Travel Award

Faculty of Health and Sport Sciences, University ofTsukuba, Japan43

The establishment of the rat model for investigating the roles of
exercise-increased blood BDNF

Moe Yamashita

Faculty of Health & Sport Sciences, University ofTsukuba, Japan

44

Hippocampal glycogen loading with exhaustive exercise enhances
hippocampus-dependent learning and memory: A short-term sports
conditioning targeting memory function

Mariko Soya
*Travel Award

Department of Psychiatry, Center for Psychiatric
Neurosciences, Lausanne University Hospital,
Lausanne, Switzerland

45

Withdrawn

46

Effects of inosine monophosphate and exercise on nNOS-related
protein expression in dorsal and ventral hippocampus

Yuki Tomiga

Fukuoka University

47

Enriched environment does not increase ambulatory physical activity
in mice: involvement of social interaction

Daisuke Funabashi*Travel Award

Human Health Science, Tokyo Metropolitan
University, Tokyo, Japan

48

Orexin receptor 1 is necessary to evoke voluntary wheel runningbehavior through regulating monoaminergic neurons

Shingo Soya

International Institute of Integrative Sleep Medicine(WPI-IIIS), Tsukuba university

49

Effects of Low Intensity Exercise on Amyloid Precursor Protein
Production by Iron Metabolism in Alzheimer's Disease Mice

Dong Hun Choi
*Travel Award

Exercise Biochemistry Laboratory, Korea NationalSport University, Seoul, Korea

International Sport Neuroscience Conference 201907

Session 3: Exercise and neurodegener ative disease

Ignacio Torres Aleman, Ph.D.
Cajal Institute, Madrid. Spain

Insulin peptides as mediators of neuroprotection
by exercise
Beneficial actions of physical activity on brain function have been
related to a variety of activity-dependent processes triggered byexercise such as enhanced blood perfusion, tissue remodeling (i.e.:
neurogenesis and angiogenesis), improved oxidative defence, oreven immune modulation. However, ever since the reported exercise-dependent increase in local growth factor production (i.e.:
BDNF) more than 20 years ago, evidence of a key role of trophic
factors in neuroprotection by exercise has become robust. The nature and sources (i.e.: local, blood, muscle) of trophic inputs to thebrain during exercise are probably still not fully described, but animportant origin for exercise-mediated trophic input are circulating
hormones such as insulin-like growth factor I (IGF-I). During thelast two decades we have been analyzing the role of IGF-I as a mediator of exercise neuroprotection and have found that participatesin the striking variety of processes known to be positively affectedby exercise. Stemming from the original observation that exercise
increases brain uptake of serum IGF-I -resembling the capture byother target organs of IGF-I such as skeletal muscle, this growth

factor has been shown to modulate new neuron formation, synaptic
plasticity, anti-apoptotic and anti-oxidant defenses, inflammation,and even mood and reward. Due to its wide cytoprotective actions,the role of IGF-I in treatment and prevention of brain diseases by
exercise seems logical, whereas its actions on higher brain functions (learning and memory, mood, attention..etc), already found ininvertebrates, demands a better knowledge of the processes modulated by IGF-I at the molecular, cellular and system level. In thisregard, our recent work in collaboration with other labs is showing
an interaction of IGF-I with insulin in brain glucose handling, acell-specific role of IGF-I in metaplasticity processes, and a directmodulatory role on orexinergic circuits impacting on mood andreward. Collectively, our observations provide molecular targets,
cellular mediators, circuits, and specific brain skills affected by insulin-peptides. Hence, modulation of the activity of these hormonesby exercise may explain part of its neuroprotective actions while its
in-depth understanding will likely provide novel intervention targets in preventing and treating neurodegeneration.

Zsolt Radak, Ph.D.
University of Physical Education, Budapest, Hungary

The link between exercise, microbiome andAlzheimer Diseases
Exercise is documented to be beneficial to vertebrate organisms
as it increases skeletal muscle, respiratory-cardiovascular fitness,cognitive functions, and extending health span. It is also known
that exercise has powerful effects on microbiome. It has been reported that exercise-induced changes in microbiome has an impact
on endurance capacity and neurogenesis. It is also known that
regular physical exercise and nutritional intecrvention decreases
both the incidence and symptoms intensity in Alzheimer Disease(AD) along with changes in microbiome including those in the gut,
while direct link has not been established. We have examined if
exercise-induced changes in gut microbiome have beneficial effecton cognitive functions using APP/PS1 mice. Results showed thatwhen APP/PS1 mice subjected to exercise and probiotic treatments

08

International Sport Neuroscience Conference 2019significantly over-performed controls in maze tests, while exercise,prebiotic alone and together decreases of beta-amyloid plaques, andincreased microglia numbers around plaques. At molecular level
improvement in cognitive functions was associated with increased
expression 8-oxoguanine DNA glycosylase-1 (OOG1) in APP/PS1
mice. Microbiome data revealed that AD development is associatedwith leaky gut, which can be prevented by exercise training. Dataalso show that exercise training increases the levels of anti-inflammatory microorganism, such as bacteria that are involved inbutyrogenesis. These data together show beneficial effects exercise
and probiotic on cognitive functions in mouse model, which can beapplied in benefit of human.

Chia-Liang Tsai, Ph.D.
National Cheng Kung University, Taiwan

Exercise types and neurocognitive performancein mild cognitive impairment
using the ERPs and neural oscillatory will be introduced. Regularphysical exercise is a promising nonpharmacological intervention
to retard cognitive aging. Potential neurobiological mechanisms
could be increased levels of peripheral exercise-induced exerkines,
such as exercise-induced neuroprotective growth [e.g., brain-derived neurotrophic factor (BDNF) and insulin-like growth factor
1 (IGF-1)] and pro-angiogenic factors [e.g., vascular endothelial
growth factor (VEGF) and fibroblast growth factor 2 (FGF-2)] andreduced levels of pro-inflammatory cytokines [e.g., tumor necrosis
factor-α (TNFα), Interleukin-1-beta (IL-1β), IL-6, IL-8, and IL15]. The effects of acute and chronic exercise (aerobic vs. resistance
exercise modes) interventions on neurocognitive performance (i.e.,behavior and ERPs) and neuroprotective (e.g., BDNF, IGF-1, VEGF,
and FGF-2) and inflammatory (e.g., TNF-α, IL-1β, IL-6, IL-8, andIL-15) biomarkers in older individuals with MCI will be stated. In
addition, whether the two exercise modes produce divergent effects
on these molecular biomarkers and neurocognitive performance inthem will also be explored.

Alzheimer’s disease (AD) is a common progressive neurodegenerative disorders. To date, no curative pharmacotherapy exists for
AD. Therefore, strategies for prevention and/or delay AD disease
onset or progression need to be examined and implemented. Better physical fitness levels induced by regular physical exercise has
been recommended as an effective non-pharmacological intervention capable of modifing the neurocognitive disease. Since theindividuals with family history of Alzheimer’s disease and ApoE-4(ADFH-ApoE-4) or mild cognitive impairment (MCI) have a higher risk of suffering dementia, the two groups will thus be discussed
in this talk. Event-related potentials and event-related neural oscillatory are two electroencephalographic signals which are sensitive
enough to identify elderly patients with early cognitive decline ordisease progression to MCI and/or AD. Based on neuropsychological problems found in individuals with ADFH-ApoE-4/MCI and
executive functioning deficits being associated with poorer physicalfitness, the role of physical fitness in the relationship between MCI/
ADFH-ApoE-4 and the neurophysiological performance explored

Session 4: Sports Performance and neurorehabilitation

Naznin Virji-Babul, Ph.D.
University of British Columbia, Canada

Brain recovery from sports related concussion:
Is there a new normal?
Children and youth are at a greater risk of concussions than adults,
and once injured, take longer to recover. The risk of a repeat concussion during recovery is also significantly higher, with subsequent injuries further complicating and prolonging recovery. The
increased incidence of sports-related concussion in youth and thepotentially serious long-term negative impact on their developing
brains has enormous repercussions. Little is still known about thesubtle and widespread changes in the brain and the effect of concussion on the developing brain.
My team has been collecting resting state EEG inadolescents with sports related concussion for the past few years.
Probing the brain during the “resting state” has emerged as a
powerful tool to map the functional organization of the brain.
Analysis of resting state functional networks has emerged as asignificant new way to investigate brain connectivity between
regions that are functionally linked in both healthy and disease/
injury states. We were the first to report significant differencesin functional networks in the frontal regions of the brain inadolescents with concussion using resting state fMRI. Importantly,
this work showed that functional connectivity measures derived
from resting-state EEG signals support the f MRI f indings,
showing clear concussion related changes in local networks in thedorsolateral prefrontal cortex that subserve cognitive function inadolescents. This work established that resting state EEG signals
provide a simple, low-cost, non-invasive and direct measureof brain connectivity that differentiates healthy controls fromindividuals with brain injury.
Our longitudinal data show that the functional connectivityof the concussed adolescents typically does not return to normal
even after one-year post-injury. This may be due to continued
neural trauma, reorganization of brain connectivity, or both. In thistalk I will discuss our findings showing disturbed brain dynamics
in adolescents who have experienced a sport related concussion. I
will then present pilot data on interventions directed at facilitating
brain recovery using several different methods such as physicalexercise and transcranial direct current stimulation (tDCS).

International Sport Neuroscience Conference 201909

Kimitake Nakazawa, Ph.D.
The University of Tokyo, Department of Integrated Sciences, Japan

Paralympic brain-compensation and reorganization in human brainOne of the primary goals of basic neurorehabilitation studies is tofigure out the underlying neural mechanisms in the reorganizationof central nervous system after rehabilitation interventions. From
this perspective the athletes with disabilities, such as Paralympic
athletes would be the attractive research model, since they canshow the use-dependent plastic changes in CNS after the long-term
intervention of intensive physical training.
We have recently found that the brains of Paralympic athletes
are reorganized uniquely in such a manner dependent on disability
types and athletic-specific training. Factors playing the major rolesin the reorganization are most probably use-dependent plasticity
and disability-specific compensations.
In this presentation our current data obtained from thefollowing Paralympic athletes with various types of disabilities
who have been engaged in different sports will be introduced.
A) A long jumper and a high jumper with below knee amputee
Both para-athletes showed bilateral activation of the leg motor area
when they were producing knee joint torque during fMRI recording, while no such bilateral motor area activation was observed
for the non-amputated leg. The transcranial magnetic stimulation(TMS) study for the high jumper confirmed that the ipsilateral corticiospinal tract of the amputated side knee extensor has the higher
excitability and is recruited when he produces knee extension
torque to move the prosthesis.
B) The archer with congenital upper-limb loss
The highly skilled lower leg function and large expansion of toe
motor area in the primary motor cortex were observed with both
fMRI and TMS experiments.

10International Sport Neuroscience Conference 2019

C) Power lifters with spinal cord injury
The specifically improved upper-limb motor function assessed with
the isometric grip force stability test after spinal cord injuries wasfound. The subsequent experiment showed that the higher stability
in grip force was common in persons with complete spinal cord
injury regardless of sports participation, although there is still possibility that the higher force stability would be further improved in
power lifters.
D) A swimmer with cerebral palsy
Electromyographic (EMG) activity and motion recording were performed during swimming for the former Paralympic gold medalist.
The EMG activities and motion analysis showed that she performed
well-coordinated dynamic swimming movement without spasticity
in water, whereas on land she showed a typical hemiplegic type of
posture and gait pattern with spastic elbow flexor activity. Although
the MRI image of her brain revealed a large lesion in her left sensory-motor area, the remarkable brain reorganization was found tooccur with the TMS experiment. The neural mechanisms enabling
dynamic swim motion in water will be presented with the current
knowledge regarding interaction between autonomic nervous activity and motor system, which can be applied to neurorehabilitation
for patients after damages to the CNS such as stroke and spinal
cord injury.
In the overall discussion the hypothetical neural mechanisms
inducing reorganization of their brains will be presented withclinical implication in neurorehabilitation.

Session 5

Henriette van Praag, Ph.D.
Brain Institute and Charles E. Schmidt College of Medicine, Florida Atlantic University, USA

Physical activity and muscle-brain crosstalk
Most neurons in the adult central nervous system are terminallydifferentiated and cannot be replaced when they die. However,small populations of new neurons are generated in the matureolfactory bulb and the hippocampus. In the adult hippocampus,
newly born neurons originate from putative stem cells that exist in
the subgranular zone of the dentate gyrus. The production, survival
and functional integration of newborn hippocampal cells is strongly upregulated by voluntary wheel running in rodents. Enhanced
adult hippocampal neurogenesis is correlated with enhanced synaptic plasticity, spatial navigation and pattern separation in rodents.
A recent focus of our research is to understand the functional contribution of the different structures that provide direct input to newneurons in the adult brain, as well as the reorganization of new neuron networks by short-term (one week) or long-term (at least one
month) exercise. For these studies we combined retroviral labelingwith rabies virus as a retrograde tracer to delineate the circuitryof new neurons during their development in the adult brain. Thereis substantial upregulation of innervation of new neurons by theentorhinal cortex supporting the proposed role of new neurons inspatial and contextual memory processes. These studies show that
newly born neurons are an integral part of local intra-hippocampal
circuits as well as more distal (sub)cortical networks, and that theseconnections are subject to exercise-induced plasticity. Another aspect of our work is to investigate the peripheral triggers that may
mediate exercise induced changes in the brain. We have observedthat compounds that activate energy metabolism pathways in muscle, such as AMP-kinase agonist AICAR, can also benefit adultneurogenesis and memory function. Next, we set out to identify
factors that may be released into circulation from muscle (myokines)that could influence brain function. Using proteomic analyses, wefound that conditioned medium derived from skeletal muscle cell
cultures treated with AICAR contains factors that can promote differentiation of neural stem cells in vitro. In particular, we identified
lysosomal enzyme Cathepsin B (Ctsb) as a novel myokine. Analyses across species in mice, monkeys and humans showed that thisfactor upregulated in plasma with exercise. In humans, these changes correlated with improved fitness and hippocampus-dependent
memory function. A recent focus of work is to determine whether
myokine levels may be upregulated in aging subjects following an
exercise intervention. Overall, our research evaluating the relationship between myokines, adult hippocampal neurogenesis, neurotrophin levels and memory function aims to further our understandingof effects of exercise on the brain.

Session 6

Art F. Kramer, Ph.D.
Northeastern University, USA

Walking Towards a Healthy Brain and Mind
The presentation will focus on recent research from our laboratories that has examined the effects of exercise training interventions
and physical activity on cognitive and brain health. I will discussresearch that has examined changes in brain structure and/or function along with behavioral measures of cognition in interventions
lasting from several weeks to 1 year. Study populations will include children, young and middle-aged individuals, and the elderlyin addition to a variety of patient groups. Although the focus will
be on training to improve cardiorespiratory fitness I will also briefly cover resistance training and well as multi-modal cognitive andexercise training program. Finally, the presentation will identify
gaps in the literature and potential solutions.

International Sport Neuroscience Conference 201911

Luncheon Seminar @ 1f Conference Room 102

Maria Llorens-Martin, Ph.D.
Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM, Madrid, Spain

Human adult neurogenesis as a mechanism ofbrain plasticity in physiology and pathology
Memory impairment in Alzheimer’s Disease (AD) can be attributed to a significant decline in the functioning of the hippocampal
formation, a brain region crucial for learning and memory. Moreover, this structure hosts one of the most unique phenomena of
the adult mammalian brain, namely the addition of new neurons
throughout lifetime. This process, named adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to
the entire hippocampal circuitry. While synapse loss and consequent death of mature neurons may be responsible for much of the
hippocampal malfunctioning in AD, studies in mice suggest thatthe disease could also target AHN. Nonetheless, direct evidence of
AHN in humans has remained elusive. Thus, determining whether
new neurons are continuously incorporated to the human dentate
gyrus (DG) during physiological and pathological aging is a crucial question with outstanding therapeutic potential. This talk will
present solid evidence supporting the occurrence of continued neurogenesis in the human hippocampus of aged healthy subjects andAD patients. By combining human brain samples obtained undertightly controlled conditions and state-of-the-art tissue processing
methods, we have identified thousands of immature neurons in
the DG of neurologically healthy human subjects up to the ninth
decade of life. These neurons exhibited variable degrees of maturation along differentiation stages of AHN. In sharp contrast, thenumber and maturation of these neurons progressively declined as
AD advanced. These results demonstrate the robust persistence of
AHN during both physiological and pathological aging in humans,and evidence impaired neurogenesis as a potentially relevant mechanism underlying memory deficits in AD that might be amenable
to novel therapeutic strategies. In this regard, our studies in murine
models of AD point to neuroprotective effects of lifestyle modifying factors. Solid evidence of the positive effects exerted by physical exercise and environmental enrichment on animal models ofneurodegenerative diseases will be presented.

12International Sport Neuroscience Conference 2019

References:
1. Adu lt h ippoca mpal neu roge ne sis is abu nd a nt i nneurologically healthy subjects and drops sharply in patients with
Alzheimer's disease. Moreno-Jiménez EP, Flor-García M, TerrerosRoncal J, Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, LlorensMartín M. Nature Medicine. 2019 Apr;25(4):554-560. doi: 10.1038/
s41591-019-0375-9. PMID: 30911133
2. Activity-Dependent Reconnection of Adult-Born Dentate
Granule Cells in a Mouse Model of Frontotemporal Dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, PallasBazarra N, Rábano A, Sah N, van Praag H, Giacomini D, SchinderAF, Ávila J, Llorens-Martín M. Journal of Neuroscience. 2019 Jul
17;39(29):5794-5815. doi: 10.1523/JNEUROSCI.2724-18.2019. Epub
2019 May 27. PMID: 31133559
3. Novel function of Tau in regulating the effects of external
stimuli on adult hippocampal neurogenesis. Pallas-Bazarra N,
Jurado-Arjona J, Navarrete M, Esteban JA, Hernández F, Ávila J,
Llorens-Martín M. EMBO Journal. 2016 Jul 1;35(13):1417-36. doi:
10.15252/embj.201593518. Epub 2016 May 19. PMID: 27198172
4. GSK-3β overexpression causes reversible alterations on
postsynaptic densities and dendritic morphology of hippocampal
granule neurons in vivo. Llorens-Martín M, Fuster-Matanzo A,
Teixeira CM, Jurado-Arjona J, Ulloa F, Defelipe J, Rábano A,
Hernández F, Soriano E, Avila J. Molecular Psychiatry. 2013
Apr;18(4):451-60. doi: 10.1038/mp.2013.4. Epub 2013 Feb 12. PMID:
23399915.

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iMScope TRIO
イメージング質量顕微鏡
顕微鏡による形態観察と，質量分析計による構造解析を一体化した，新しいタイプの分析装置です。
顕微鏡で観察された高解像度の形態画像と，質量分析計によって測定された分子の分布画像。異なる2つの原理から検出された画像を重ね合わせたイメージング質量分析画像を解析することで，研究はより速く，より正確になります。
最先端技術を凝縮したiMScopeが，ESI-MSとしても使用できる*
iMScope TRIOとしてさらなる進化を遂げました。
*付け替えはフィールドエンジニアの作業となります。

イメージング質量分析では，試料の組織上の位置情報を残したまま，生体分子や代謝物を直接質量分析計で測定できます。測定から得られた位置情報と質量スペクトル中の特定イオンの信号強度によって，各種生体分子の二次元分
布図を画像化します(MSイメージング)。このイメージング質量分析に特化した装置，これが，新たに開発された質量顕微鏡iMScopeです。光学顕微鏡と質量分析計がひとつになった，まったく新しいハイブリッド型の顕微鏡が，物質の構
造解析を可能にし，あらゆる分野の研究の可能性を拡げます。

application

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マウス小脳の脂質分布の可視化
疾患にはさまざまな物質が関与しています。イメージング質量分
析では，指定した質量範囲で測定を行なうため，異なった質量を持つ物質それぞれの分布情報を一度のスキャニングで得ることお問い合わせができます。
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ＭＩＣＥとは？

つくばから世界へ発信する事をお手伝いします。

MICEとは、企業等の会議（Meeting）、企業等の行う報奨・研修旅行（インセンティブ旅行）（Incentive Travel）、国際機関・団体、学会等が行う国際会議（Convention）、展示会・見本市、イベント（Exhibition/Event）の頭文字のことであり、多くの集客交流が見込まれるビジネスイベン
トなどの総称です。 MICEは、企業・産業活動や研究・学会活動等と関連している場合が多いため、一般的な観光とは性格を異にする部分が多いものです。このため、観光振興という文脈でのみ捉えるのではなく、MICEについて、「人が集まる」という直接的な効果はもちろん、人の集積や交流から派生する付加価値や大局的な意義についての認識を高める必要があります。
具体的には、以下に掲げる３つの主要な効果が考えられます。
MICE開催を通じて世界から企業や学会の主要メンバーが我が国に集うことは、我が国の関係者と海外の関係者のネットワークを構築し、新しいビジネスやイノベーションの機会を呼び込むことにつながります。

TECHNICAL VISIT
テクニカル ビジット

MICE開催MICE開催を通じて世界から企業や学会の主要メンバーが我が国に集うことは、我が国の関係者と海外の関係者のネットワークを構築し、新しいビジネスやイノベーションの機会を呼び込むことにつながります。を通じた主催者、参加者、出展者等の消費支出や関連の事業支出は、MICE開催地域を中心に大きな経済波及効果を生み出します。MICEは会議開催、宿泊、飲食、観光等の経済・消費活動の裾野が広く、また滞在期間が比較的長いと言われており、一般的な観光客以上に周辺地域へのテクニカルビジットとは、先進技術を学びに行く視察旅行のこと。 経済効果を生み出すことが期待されます。

産業視察だけでなく、行政視察も含まれます。
現地の企業や行政機関、専門機関などの訪問先との交渉や視察のコーディネートが必要となることから、テクニカルビジットを扱う旅行会社は視察分野ごとの専門知識を持っていること、もしくは専門代理店との連携が必須条件となります。
弊社スタッフは、20年以上の経験者も多く、必ずお客様のご希望に添えるご提案をさせていただきます。

国際会議等のMICE開催を通じた国際・国内相互の人や情報の流通、ネットワークの構築、集客力などはビジネスや研究環境の向上につながり、都市の競争力、ひいては、国の競争力向上につながります。海外の多くの国・都市が、国・都市の経済戦略の中で、その達成手段の一つとし国際会議等のMICE開催を通じた国際・国内相互の人や情報の流通、ネットワークの構
築、集客力などはビジネスや研究環境の向上につながり、都市の競争力、ひいては、国の競争力向上につながります。海外の多くの国・都市が、国・都市の経済戦略の中で、その達成手段の一つとしてMICEを位置付け、戦略分野／成長分野における産業振興、イノベーション創出のためのツールとして国際会議や見本市を活用しており、我が国においても、MICEを国・都市競争力向上のツールとして認識し、活用することが重要です。てMICEを位置付け、戦略分野／成長分野における産業振興、イノベーション創出のためのツールとして国際会議や見本国際会議等のMICE開催を通じた国際・国内相互の人や情報の流通、ネットワークの構築、集客力などはビジネスや研究環境の向上につながり、都市の競争力、ひいては、国の競争力向上につながります。海外の多くの国・都市が、国・都市の経済戦略の中で、その達成手段の一つとしてMICEを位置付け、戦
略分野／成長分野における産業振興、イノベーション創出のためのツールとして国際会議や見本市を活用しており、我が国においても、MICEを国・都市競争力向上のツールとして認識し、活用することが重要です。市を活用しており、我が国においても、MICEを国・都市競争力向上のツールとして認識し、活用することが重要です。

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Map of the Conference

International Congress Center "EPOCHAL TSUKUBA"

1F

2F

↑

↑

Restaurant↑★ Reception★Poster Session

Hall 200

Room
102

↑

Main
Entrance
Sep.18th 19:30~
Reception/
Poster Award Ceremony

Sep.19th 12:00~
Luncheon Seminar

The 1st ISNC Committee Members
President

Hideaki Soya

Vice-Presidents

Pierre J. Magistretti, Jyunichi NabekuraCore members

Ichiro Kita, Toshio Mikami, Ryoichi Nagatomi, Takeshi Nishijima, Tetsuya Shiuchi, Nobusuke Tan,
Kiyoji Tanaka, Hidefumi Waki

International core members

Joon-Yong Cho, Art F. Kramer, Maria Llorens-Martin, Hyo-Youl Moon, Henriette van Praag, Zsolt Radak,Ignacio Torres Aleman, Michael Yassa

Executive committee chair

Masahiro Okamoto

Executive committee

Kyeongho Byun, Takemune Fukuie, Hikaru Koizumi, Takashi Matsui, Genta Ochi, Kazuya Suwabe

Staff

Yoshiko Asao, Chorphaka Damrongthai, Francois Grenier, Toshiaki Hata, Taichi Hiraga, Mitsue Honma,
Ryouma Kinoshita, Jyunko Kobayashi, Ryuta Kuwamizu, Rin Nakagawa, Kengo Nakamura,
Leandro Kansuke Oharomari, Seohee Park, Ha Min Seong, Takuta Shibasaki, Kanako Takahashi,
Mana Yakushiji, Ayumu Yamada, Moe Yamashita

Supporting Members
味の素株式会社 (Ajinomoto Co., Inc.)

旭光物産株式会社 (KYOKKO BUSSAN CO., LTD.)

インターリハ株式会社 (Inter Reha Co., Ltd.)

公益社団法人日本エアロビック連盟 (Japan Aerobic Federation)

エイコム株式会社 (Eicom Corporation)

タビットツアーズ株式会社 (TABBIT CO.,LTD.)

株式会社アイ・シー・エム (ICM CO.Ltd.)

ナカライテスク株式会社 (NACALAI TESQUE, INC.)

株式会社アミノアップ (Amino Up Co., Ltd.)

日本エスエルシー株式会社 ( Japan SLC,Inc.)

株式会社杏林書院 (Kyorin Shoin Co. Ltd.)

日本薬品工業株式会社 (Nihon Pharmaceutical Industry Co.,Ltd.)

株式会社講談社 (Kodansha Ltd.)バイオリサーチセンター株式会社 (Bio Research Center Co. Ltd.)

株式会社ナイカイ (NAIKAI, Co.)

ヤトロ電子株式会社 (YATORO ELECTRONICS CO., LTD.)

株式会社フィジオテック (Physio-Tech Co., Ltd.)

Acknowledgments
This conference is supported in part by the program for promoting the enhancement of research universities, Advanced Research Initiative for
Human High Performance (ARIHHP) of University of Tsukuba, The Nakatomi Foundation, the Japan Society for the Promotion of Science Grants
16H06400 (WILLDYNAMICS), The Uehara Memorial Foundation, The Naito Foundation, Narishige Neurosciecnce Research Foundation.

International Sport Neuroscience Conference 201923