Cyclohexanone
August 12, 2012
Version: 1

Product Safety Summary for Cyclohexanone
SUBSTANCE NAME
Cyclohexanone
Cyclohexanon
Cyclohexanone (7CI, 8CI, 9CI)
AnonAnone
Pimelin ketone
Pimelic ketone

GENERAL STATEMENT
Cyclohexanone is a light yellow liquid with an odor that resembles peppermint oil. It is an organic compoundthat is mainly used as a chemical intermediate for the production of monomers and as a solvent in a range offormulated products for use by professional users and consumers. In general, the health hazards are low, butprotection against inhalation, skin and eye contact is required. Cyclohexanone is a flammable liquid and it canbe regarded as non-hazardous to the environment.

CHEMICAL IDENTITYEC Name: cyclohexanone
EC-No. : 203-631-1
CAS-No. : 108-94-1
Molecular formula: C6H10O
Structural formula:

USES AND APPLICATIONS
Cyclohexanone is a light yellow liquid. It is produced by the oxidation of cyclohexane and subsequent
treatment of the reaction product. Cyclohexanone is mainly used as an intermediate to produce monomers,
particularly for the production of well-known plastics like polyamide. In industrial use, it is also commonly used
as intermediate for the manufacturing of fine chemicals. Furthermore it finds application as a laboratory reagent
and as a solvent in a wide variety of formulated products, including products for professional uses andconsumer products. It is used in formulated products like adhesives, coatings, paints, printing inks and biocidal
and plant protection products.

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PHYSICAL CHEMICAL PROPERTIES
Cyclohexanone is a light yellow liquid at room temperature and pressure, with a smell like peppermint oil.

Melting point/range: -31 °C at atmospheric pressure
Boiling point/boiling range: 154.3 °C at 1013.25 hPa
Decomposition temperature: Not determinedFlashpoint: 44 °C (closed cup)
Flammability (solid, gaseous): Flammable upon ignition
Selfignition temperature: 420 °C at 1013 at hPa
Explosion limits:
Lower: 1.05 vol % (air)Upper: 9.9 vol % (air)Explosive properties: Non explosive.
Molecular weight: 98.143
pH value: 6.6 at 20 °C
log Pow: 0.86 at 25 °C
Vapor pressure: 7 hPa at 30 °C
Vapor density: Not determined
Relative density: 0.9465 g/cm3 at 20 °C
Dissociation constant: Not applicable
Solubility in/Miscibility with water: 86 g/l at 20 °C
Dynamic Viscosity: 2.2 mPa.s at 25 °C
Oxidizing properties: No oxidizing properties

HEALTH EFFECTS
Cyclohexanone is moderately hazardous for human health. The acute toxicity via oral and dermal exposure isproved to be low. However, inhalation exposure studies showed some adverse acute effects, sufficient enoughto classify it as hazardous. Also irritation and corrosivity studies showed adverse effects on the skin and in theeyes. On the other hand, the results of oral repeated dose testing give no rise to concern. Mutagenicity tests, invitro and in vivo, were negative as well as carcinogenicity, fertility and reproductive toxicity studies.
Cyclohexanone is a flammable liquid and care needs to be taken to avoid the risks of this inherent hazard
property when handling Cyclohexanone in pure form or in high concentrations.

EFFECT ASSESSMENTRESULT

Acute Toxicity (oral/dermal/inhalation)

Cyclohexanone has a low acute toxicity for oral and dermal
exposure but inhalation exposure studies suggest that it needs
to be considered harmful for that exposure route.

Irritation/Corrosivity

Cyclohexanone is irritating and corrosive to the skin and to the2

Cyclohexanone
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Version: 1(skin/eye/respiratory tract)eyes.

Sensitization

Based on the available data, Cyclohexanone is not considered(skin/respiratory tract)

to have skin or respiratory sensitization properties.

Mutagenicity

All available test data indicates that Cyclohexanone does notcause mutagenic effects.

Carcinogenicity

Oral carcinogenicity study data suggests that Cyclohexanoneis not carcinogenic.

Reproductive Toxicity

All available data suggest that Cyclohexanone has no adverse
fertility or reproductive effects.

Repeated Dose Exposure

Test results with oral and intravenous exposure indicate that
there is no marked repeated dose toxicity.

ENVIRONMENTAL EFFECTS
Based on the values of the octanol water partition coefficient and Henry’s constant, Cyclohexanone distributes
mainly into water and air. Cyclohexanone’s toxicity to aquatic species is low. It is also readily biodegradable
and has a low bioaccumulation potential. Also, since the overall toxicity of cyclohexanone is low, it can beconcluded that it is not hazardous to the environment or to humans through environmental exposure.

EFFECT ASSESSMENTRESULT

Aquatic Toxicity

Studies indicate that Cyclohexanone is not toxic to fish and todaphnia and has a low toxicity to algae and aquatic plants.

FATE AND BEHAVIORRESULT

Biodegradation

Cyclohexanone is readily biodegradable in water.
Biodegradability in soil and sediment is not relevant.

Bioaccumulation potential

Basing on its logPow value, significant accumulation ofCyclohexanone in organisms is not expected.

PBT/vPvB conclusion

Regarding all available data on biotic and abiotic degradation,
bioaccumulation and toxicity, it can be stated that thesubstance does not fulfill the PBT criteria nor the vPvB criteria.

EXPOSURE
Human Health
Exposure can occur to workers in industrial facilities where Cyclohexanone is produced, stored, handled orprocessed. Professional users or consumers may come into contact with Cyclohexanone through commonlyused formulated products, such as adhesives, coatings, paints, printing inks and biocidal and plant protection
products. Based on the physical properties of Cyclohexanone skin contact and inhalation are the most likely
routes of exposure. Consumer applications are such that consumer exposure will typically be infrequent, for3

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brief periods or in small quantities. Therefore the use of Cyclohexanone by the consumer is not considered topose a health risk. However, the level of exposure to professional and industrial users may be such that risk
management measures must be taken.

Environment
The probability of release of Cyclohexanone in concentrated form to any of the environmental compartments is
low under normal industrial use conditions. Also the environmental release of Cyclohexanone from formulated
products will be insignificant under normal use conditions. Cyclohexanone is readily biodegradable; therefore,
accidental release of small quantities to waste water or surface water should not cause further environmentalexposure.

RISK MANAGEMENT RECOMMENDATIONS
Cyclohexanone poses some risks that need to be managed. Exposure via inhalation, skin and eye contact
must be avoided, specifically by industrial users and certain professional users. The exposure levels ofconsumers are low; therefore, typical consumer uses do not require specific risk management measures.
Personnel handling the substance need to be trained in the safe use of Cyclohexanone and workers who may
be exposed to it need to be protected by taking adequate measures to protect against chemical exposure.
Respiratory protection devices with organic gas filters must be worn, as well as protective clothing, gloves andtightly fitting safety goggles.
Also the flammability of Cyclohexanone poses risks that need to be carefully managed, so risk management
needs to focus also on fire prevention. Workers should be properly informed about the risks and trained in theprevention and protection measures to be adopted. Containers and equipment containing Cyclohexanone
should be correctly labeled clearly indicating its flammability hazard. Operations involving the possible releaseof liquid or vapor should be carried out using closed processes or, failing this, in well-ventilated areas or in
installations with local extraction systems. The creation and accumulation of static discharge during transfer ofthe substance should be controlled by precautionary measures such as grounding and bonding containers andequipment. For environmental protection in case of accidental release: do not allow product to reach sewage
system or any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Cyclohexanone is included in the OECD list of High Production Volume (HPV) chemicals.
Cyclohexanone is listed in the following Chemical Inventories: AICS, ENCS, EINECS, NZIoC, DSL Canada,IECSC, KECI, TSCA, PICCS.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Flammable liquid:

Flammable liquid Category 3; H226 Flammable liquid and vapour.

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Acute toxicity:

Category 4; Oral; H302 Harmful if swallowed.

Acute toxicity:

Category 4; Dermal; H312 Harmful in contact with skin.

Acute toxicity:

Category 4; Inhalation; H332 Harmful if inhaled.

Skin/Eye (Corrosion/irritation):

Skin Irritation Category 2; H315 Causes skin irritation.
Eye Damage Category 1; H318 Causes serious eye damage.

Labeling according to REGULATION (EC) No 1272/2008:
Pictogram:

Signal word: Danger
Hazard statements:

H226: Flammable liquid and vapour.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H332: Harmful if inhaled.
H315: Causes skin irritation.
H318: Causes serious eye damage.

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company: UBE Industries, Ltd.
Department: Caprolactam Business Unit
Address: Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo
Town/Country: Japan
Postal code: 105-8449
E-mail: ube-cpl@ube-ind.co.jp

Additional information can be found at:
http://www.ube.co.jp

GLOSSARY
Acute toxicity

Harmful effect resulting from a single or short term exposure to asubstance.

AICS

Australian Inventory of Chemical Substances.

Biodegradation

Decomposition or breakdown of a substance under naturalconditions (actions of micro-organisms etc).

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Progressive accumulation in living organisms of a chemicalsubstance present in the environment.

Canadian DSL

Domestic Substances List of Canada.

Carcinogenicity

Substance effects causing cancer.

CASChemical Abstracts Service (division of the American ChemicalSociety).

Chronic toxicity

Harmful effect after repeated exposures or long term exposure to asubstance.

EINECS

European Inventory of Existing Commercial Chemical Substances

ENCS

Existing Notified Chemical Substances (Japan).

Flash point

The lowest temperature at which vapor of the substance may form
an ignitable mixture with air.

Genotoxicity

Substance effect that causes damage to genes, including
mutagenicity and clastogenicity.

GHS

Globally Harmonized System of Classification and Labeling ofChemicals

HPV

High Production Volume Chemicals.

Hydrolyze

Undergo hydrolysis; decompose by reacting with water.

IECSC

Inventory of Existing Chemical Substances Produced or Importedin China.

Intermediate

Substance that is manufactured for and consumed in or used forchemical processing in order to be transformed into anothersubstance.

KECI

Korean Existing Chemical Inventory.

Monomer

Means a substance which is capable of forming covalent bonds
with a sequence of additional like or unlike molecules under theconditions of the relevant polymer-forming reaction used for theparticular process.

Mutagenicity

Substance effect that cause mutation on genes.

NZIoC

New Zealand Inventory of Chemicals

PBT

Persistent, bioaccumulative, toxic chemical.

Persistence

Refers to the length of time a compound stays in the environment,
once introduced.

PICCS

Philippine Inventory of Chemicals and Chemical Substances.

Risk Management Measures

Engineering controls, conditions and protective equipment needed
to be implemented to ensure that the risks to human health and theenvironment are adequately controlled.

6REACH (EC) No. 1907/2006

Cyclohexanone
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European Commission Regulation concerning the Registration,
Evaluation, Authorization and Restriction of Chemicals.

REGULATION (EC) No 1272/2008

European Commission Regulation on Classification, Labeling andPackaging of Substances and Mixtures.

Reproductive toxicity

Including teratogenicity, embryotoxicity and harmful effects onfertility.

Sensitizing

Allergenic.

Sediment

Topsoil, sand and minerals washed from land into water forming in
the end a layer at the bottom of rivers and sea.

TSCA

Toxic Substance Control Act (USA).

Vapor pressure

A measure of a substance’s property to evaporate.

vPvB

Very persistent, very bio-accumulative.

DISCLAIMERThis information is furnished without warranty, expressed or implied, except that it is accurate to the best
knowledge of UBE INDUSTRIES, LTD. The data on this sheet related only the specific material designatedherein. UBE INDUSTRIES, LTD. assumes no legal responsibility for use or reliance upon these data.

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