Safety Summary Sheet
5-Ethylidene-2-norbornene（CAS NO. 16219-75-3）
SPECIES

5-Ethylidene-2-norbornene

PROTOCOL

RESULTS（CAS NO.: 16219-75-3）
PHYSICAL-CHEMICAL
2.1

Melting Point

Unknown

<-80℃

2.2

Boiling Point

Unknown

147.6℃ (1013hPa)

2.3

DensityUnknown

Relative density : 0.896 (20℃)

2.4

Vapour Pressure

Unknown

5.6hPa (20℃)

2.5

Partition Coefficient(log Kow)

OECD TG 107

3.82 (25℃)

2.6.1A

Water Solubility

OECD TG 105

80mg/L (25℃)

2.6.1.B

Dissociation Constant（pKa）

No data(no dissociable groups)

ENVIRONMENTAL FATE AND PATHWAY
3.1.1

Photodegradation

Calculation by
AOPWIN v1.89

Rate constant of degradation by OH
radical : 1.48x10-10cm3/(molec･s)

3.1.2

Stability in Water

OECD TG 111

Stable at pH 4, 7 and 9 (50℃)

3.1.3

Stability in Soil

No data

3.2

Monitoring Data

No data

3.3.1

Transport between
Environmental Compartments

Calculation
byMackey Level Ⅰ
Fugacity model

Air : 96.0%
Water : 0.6%
Soil : 3.3%
Sediment : ＜0.1%
Suspended sediment : ＜0.1%

3.3.2

Distribution

Calculation
EPIWIN

LogKoc : 2.96-3.01

3.4

Biodegradation

3.5

BOD-5, COD or BOD-5／
COD ratio

3.6

Bioaccumulation(Koc etc.）byOECD TG 301C

0% (28d, BOD)
1% (28d, GC)
No data

Cyprinus carpio

OECD TG 305C

BCF : 70-160 (0.1mg/L), 61-159(0.01mg/L)

Brachydanio
rerioOECD TG 203;
Annex to Dir.
92/69/EEC(1992): Part C.1;
USEPA (1996)
712-C-96-118;
USEPA(1996)
712-C-96-118:O
PPTS 850.1075

LC50(96h) : 7.6mg/L (semistatic)

Oryzias latipes

OECD TG 203

LC50(96h) : 7mg/L (semistatic)

Daphnia magna

OECD TG 202

EC50(48h) : 3.34mg/L

ECOTOXICOLOGY
4.1

4.2

Acute Toxicity to Fish

Acute Toxicity to Aquatic

15-Ethylidene-2-norbornene

SPECIESPROTOCOL

RESULTS

Daphnia magna

OECD TG 202

EC50(48h) : 7.3mg/L

Selenastrum
capricomutumOECD TG 201;
Annex to Dir.
92/69/EEC(1992): Part C.3;
USEPA (1996)
712-C-96-164

EC50(96h, biomass) : 3.68mg/L,NOEC(96h, biomass) : <1.20mg/L
EC50 (96h, growth rate) : 8.93mg/L,NOEC(96h, growth rate) :<1.20mg/L

Selenastrum
capricomutumOECD TG 201

EC50(72h, biomass) : 2.61mg/L
NOEC(72h, biomass) : 0.852mg/L（CAS NO.: 16219-75-3）
Invertebrates (Daphnia etc.)
4.3

Toxicity to Aquatic Plants(Algae etc.)

4.4

Toxicity to Microorganisms(Activated Sludge Respiration
Inhibition test etc.)

No data

4.5.1

Chronic Toxicity to Fish

No data

4.5.2

Chronic Toxicity to Aquatic
Invertebrates

Daphnia magna

OECD TG 211

LC50(21d) : >2.57mg/L
EC50(21d, reproduction rate) :2.41mg/L
NOEC(21d, reproduction rate) :1.51mg/L
4.6

Toxicity to TerrestrialOrganisms

No data

4.6.1

Toxicity to Sediment Dwelling
Organisms

No data

TOXICOLOGY
5.1

Toxicokinetics, Metabolism
and Distribution

5.2

Acute Toxicity

No dataA.

Acute Oral Toxicity

Rat

Unknown

LD50 :
male ; 2276 mg/kg
female ; 5071 mg/kg

B.

Acute Inhalation Toxicity

Rat

Unknown

LC50 :
male ; 2717 ppm
female ; 3015 ppm

C.

Acute Dermal Toxicity

RabbitUnknown

LD50 : >7168 mg/kg

D.

Acute Toxicity, Other Routes

RabbitUnknown(i.v.)

LD50 :
male ; 80.6 mg/kg
female ; 98.6 mg/kg

5.3

Irritation/Corrosion

A.

Skin Irritation/Corrosion

RabbitUnknownSlightly irritatingB.

Eye Irritation/Corrosion

RabbitUnknown

Slightly irritating

5.4

Skin Sensitization

5.5

Repeated Dose Toxicity

No dataRat

Unknown(inhalation,14 weeks)

2

NOAEL : 4.9 ppm

5-Ethylidene-2-norbornene

SPECIESPROTOCOL

RESULTS（CAS NO.: 16219-75-3）

5.6

Rat

OECD TG 407(oral gavage,28 days)

NOAEL :
male ; <4 mg/kg/day
female ; 20 mg/kg/day

Genetic Toxicity in vitro

A.

Gene Mutation(Bacterial Test etc.)

S. typhimurium
and E. coli

OECD TG 471
and 472

Negative

B.

Chromosomal Aberration

CHL/IUOECD TG 473

Negative

5.7

Genetic Toxicity in vivo

Rat

Unknown（inhalation,Dominant lethalassay）

Negative

5.8

Carcinogenicity

5.9

Toxicity to Reproduction

No dataA.

Toxicity to Fertility

RatOECD TG 421(oral gavage)

NOAEL :
Parental and pups ; 20 mg/kg
Reproductive ; 20 mg/kg

B.

Developmental
Toxicity/Teratogenicity

Rat

Unknown(inhalation,exposure period ;6-15 gestation
days)

NOAEL :
Mmaternal and Developmental ;25 ppmNot teratogenic

5.10

Other relevant information

CHO-K1-BH4

5.11

Experience with Human
Exposure

Unknown(SCE assay)

NegativeNo data

Contact : http://www.sumitomo-chem.co.jp/english/contact/

IMPORTANT: While the data and information compiled herein are presented in good faith andbelieved to be accurate or valuable, it is provided for your reference only. It is expressly or
implicitly understood that Sumitomo Chemical makes no warranty or assumes no liability or
obligation for the data and information provided.

3