bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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'bioRxiv preprint first posted online Jan. 17, 2018; doi: http://dx.doi.org/10.1101/249128. The copyright holder for this preprint (which was not
peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.

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