Product Safety Summary for Ammonium Sulphate
SUBSTANCE NAME
Ammonium Sulphate
Ammonium sulfate
Ammoniumsulfat
Diammonium sulphate
Di-ammonium sulfate
Sulfuric acid di-ammonium salt
Sulfuric acid di-ammonium salt (1:2)
Mascagnite

GENERAL STATEMENT
Ammonium Sulphate is a white odorless solid product. It is mainly used for fertilizer applications, but it hasvarious other uses in the chemical and pharmaceutical industry as well as for insecticides, herbicides,
fungicides and flame retardants. Consumer applications are such that consumer exposure will typically beinfrequent, for brief periods and to small quantities or low concentrations. Ammonium Sulphate is not known
to cause adverse human health or environmental effects and it is not classified as a dangerous product. The
usual general precautionary measures to prevent worker and environmental exposure to chemicals should
also be taken when handling Ammonium Sulphate in industrial uses. No other specific risk management
measures are required.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:ammonium sulphate231-984-1
7783-20-2
H3N.1/2H2O4SUSES AND APPLICATIONS
Ammonium Sulphate is obtained by neutralization of sulphuric acid and/or oleum with ammonia. Ammonium
Sulphate can also be obtained in the caprolactam manufacturing process. The primary application ofAmmonium Sulphate is as a fertilizer. Besides that, it is used in a variety of applications. It is used as a pHcorrective agent and as chemical intermediate in a range of chemical manufacturing processes. It finds also
application in insecticides, herbicides and fungicides, as an ingredient in pharmaceutical and cosmeticproducts, as well as in flame retardants and as laboratory chemicals. Although the substance may becontained in certain products for professional or consumer use, Ammonium Sulphate is mainly applied inpure or more concentrated form in products for industrial use.

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Product Safety Summary for Ammonium Sulphate
PHYSICAL CHEMICAL PROPERTIES
Ammonium Sulphate is a white odorless crystalline solid at room temperature and pressure.
Melting point/range:
Boiling point/boiling range:
Decomposition temperature:
Flammability (solid, gaseous):
Ignition temperature:
Explosion limits:
Lower:Upper:
Molecular weight:
pH value:log Pow:
Vapor pressure:
Relative density:
Dissociation constant:Solubility in/Miscibility
with water:>280 °C
Not applicable, as the substance decomposes before boiling
280 °C
Product is not flammable. It does not release flammable gases in contact
with water.
Not determined
Not determined
Not determined132.1395 g/mol
5-6
Not applicable
4.053E-9 hPa at 25 °C
1.77 g/cm3 at 25 °C
Not applicable, as the substance is a salt
767 g/l (at 20 °C)

HEALTH EFFECTS
Ammonium Sulphate is not classified as a hazardous substance. Its acute toxicity is low via all exposure
routes. Studies have not shown long term effects or CMR properties. Ammonium Sulphate has neither irritantnor sensitizing properties. If it is taken up in the body via ingestion or inhalation, then it dissociates in theammonium and sulphate ions (NH4 +, SO4 2-). Ammonium is an endogenous substance that serves a majorrole in the maintenance of the acid-base balance. Sulphate is a normal intermediate in the metabolism ofendogenous sulphur compounds and is excreted unchanged or in conjugated form in urine. Inhalation ofammonium in dust form should be avoided.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization(skin/respiratory tract)
Repeated Exposure

Mutagenicity
Carcinogenicity
Reproductive Toxicity

April 3rd, 2012RESULT
Ammonium Sulphate is of low acute toxicity via oral, skin andinhalation routes of exposure.
Ammonium Sulphate is not irritating to the skin or to the eyes.
Based on the available data Ammonium Sulphate is not considered
to have skin or respiratory sensitization properties.
There is no information related to repeated exposure via theinhalation route. The information on repeated exposure via theoral and dermal route suggests that there is no marked repeateddose toxicity.
Available in/vitro and in/vivo data indicate that Ammonium
Sulphate does not cause mutagenic effects.
No evidence of a carcinogenic potential was observed in
carcinogenicity studies addressing oral exposure.
Studies have not shown any fertility and teratogenicity effects.
Therefore Ammonium Sulphate is not considered as toxic forreproductivity.

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ENVIRONMENTAL EFFECTS
In aqueous solution, ammonium salts are completely dissociated into the ammonium ion and thecorresponding anion, in this case the sulphate ion. Un-ionized ammonia (NH3) exists in the aquaticenvironment and the fraction of un-ionized ammonia steeply increases with elevated pH value ortemperature. It is well known that toxicity to aquatic organisms has been attributed to un-ionized ammonia
species, and NH4 + species is considered to be non- or significantly less-toxic. Therefore toxicity values forammonium salts (such as: ammonium -sulphates, phosphates, carbonates, chlorides or nitrates), where themajor toxic component is ammonia, can be considered as equivalent.
EFFECT ASSESSMENT
Aquatic Toxicity

RESULT
Ammonium Sulphate is almost totally dissociated in ammonium
and sulphate ions in water. Depending on the pH of the water theammonium- ion is in equilibrium with some unionized ammonia.
The concentration of free ammonia is generally low. Therefore theoverall aquatic toxicity of Ammonium Sulphate is also low.

FATE AND BEHAVIORBiodegradation

RESULT
Biodegradation criteria do not apply due to the inorganic nature ofAmmonium Sulphate and its presence in the environment in ionicform.
Bioaccumulation is not expected due to the high water solubility
and the ionic nature of Ammonium Sulphate.
Ammonium Sulphate does not meet the criteria for PBT and vPvB
classification.

Bioaccumulation potential
PBT/vPvB conclusion

EXPOSURE
Human Health
Exposure can occur either in Ammonium Sulphate manufacturing facilities, by other industrial users ofAmmonium Sulphate or by professional users. Based on its physical properties, ingestion or skin contact are
the most likely routes of exposure. Of all uses of Ammonium Sulphate the uses in insecticides, herbicides andfertilizers are probably the only ones that may cause some degree of exposure to the general population.
However, in these applications the general population is only exposed to Ammonium Sulphate in diluted
form. Consumer applications are such that consumer exposure will typically be infrequent, for brief periods
or in small quantities. Therefore the use of Ammonium Sulphate by the consumer is not considered to pose ahealth risk.
Environment
Ammonium Sulphate occurs in the environment only in its dissociated form, i.e. as ammonium and sulphateions. Therefore there is no environmental exposure to Ammonium Sulphate itself. The ammonium ion is inequilibrium with non-ionized ammonia, which itself is a harmful substance. However, under typicalenvironmental conditions, the concentration of non-ionized ammonia is so low that it poses no risk.
Therefore, all uses of Ammonium Sulphate are considered to be safe for the environment.

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RISK MANAGEMENT RECOMMENDATIONS
Ammonium Sulphate is not known to cause adverse human health or environmental effects. However it is agood practice to train personnel that handle the substance and to protect workers who may be exposed toAmmonium Sulphate by taking the usual precautionary measures to protect against chemical exposure.
Therefore protective clothing, gloves and safety glasses with side shields should be worn when handlingAmmonium Sulphate. It is recommended to prevent the formation of dust, to avoid contact with eyes, skinand clothing. Good ventilation at the workplace should be provided and local suction extraction should beinstalled if dust formation cannot be avoided. Respiratory protection should be worn if local extraction isabsent or insufficient. Soiled and contaminated clothing should be removed. Ammonium Sulphate should be
kept away from foodstuffs, beverages and feed. Workers should not eat, drink, smoke or sniff while working
with the product and they should wash their hands before breaks and at the end of work. AmmoniumSulphate should be stored in dry conditions and away from water, alkaline substances, nitrites and nitrates.
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Ammonium Sulphate is included in the OECD list of High Production Volume (HPV) chemicals.
Ammonium Sulphate is listed in the following Chemical Inventories: TSCA, EINECS, ENCS, AICS, Canadian DSL,KECI, PICCS, IECSC, and NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.
Labeling according to REGULATION (EC) No 1272/2008:
Pictogram: none
Signal word: none
Hazard statements: none

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Chemical Europe, S.A
Corporate Social Responsibility
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.esAdditional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

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Product Safety Summary for Ammonium Sulphate
GLOSSARY
Acute toxicity
AICS
Biodegradation
Bioaccumulation
Canadian DSL
Carcinogenicity
CAS
Chronic toxicity
EINECS
ENCS
Flash point
Genotoxicity
GHS
HPV
Hydrolyze
IECSC
Intermediate
KECI
Monomer

Mutagenicity
NZIoC
PBT
Persistence
PICCS
Risk Management Measures

April 3rd, 2012

Harmful effect resulting from a single or shortterm exposure to a substance.
Australian Inventory of Chemical Substances.
Decomposition or breakdown of a substance undernatural conditions (actions of micro-organismsetc).
Progressive accumulation in living organisms of achemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
Existing Notified Chemical Substances (Japan).
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabeling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Inventory of Existing Chemical Substances
Produced or Imported in China.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Korean Existing Chemical Inventory.
Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
New Zealand Inventory of Chemicals
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Philippine Inventory of Chemicals and Chemical
Substances.
Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.

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Product Safety Summary for Ammonium Sulphate
REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment
TSCA
Vapor pressure
vPvB

European Commission Regulation concerning theRegistration, Evaluation, Authorization andRestriction of Chemicals.
European Commission Regulation onClassification, Labeling and Packaging ofSubstances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofrivers and sea.
Toxic Substance Control Act (USA).
A measure of a substance’s property to evaporate.
Very persistent, very bio-accumulative.

DATE OF ISSUE
April 2012

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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