1,5-Pentanediol
August 12, 2012
Version: 1

Product Safety Summary for 1,5-Pentanediol
SUBSTANCE NAME
Pentanediol
1,5-Pentandiol
1,5-Pentanediol
1,5-Pentanediol (8CI, 9CI)
Pentane-1,5-diol
1,5- Dihydroxypentane
Pentamethyleneglycol
1,5-Pentamethylene glycol
Pentyleneglycol
omega.-Pentanediol
alpha.,omega.-Pentanediol

GENERAL STATEMENT
1,5-Pentanediol is a colorless, odorless liquid. It is neither hazardous for human health nor for the environment.
1,5-Pentanediol has a wide range of applications. It has two functional groups which are useful in theproduction of various polymers and plastic products. But it also finds application in other chemical processes
as well as it is contained in different consumer products.

CHEMICAL IDENTITYEC Name: pentane-1,5-diol
EC-No. : 203-854-4
CAS-No. : 111-29-5
Molecular formula: C5H12O2

Structural formula:

USES AND APPLICATIONS
1,5-Pentanediol is obtained after treatment of the mixture of products resulting from the oxidation of
cyclohexane with air. 1,5-Pentanediol is used to produce materials made of polyester or polyurethane, for themanufacturing of monomers, for the manufacture of polyester polyols, polycarbonatedioles and acrylic
monomers, for the production of delta valerolactone and for molecules that act as reactive diluents, for theproduction of halogenated substances and for the production of adhesives, putties and sealing compounds,
cleaners and auxiliary agents. 1,5-Pentanediol is also used in the processes to produce hydrogen, hydrogen11,5-Pentanediol
August 12, 2012
Version: 1peroxide, sodium perborate and peroxyacetic acid and as an intermediate for pharmaceutical products. It isused as an ingredient for the production of polymeric thickeners, plasticizers for polyvinyl chloride, sizingagents, surfactants, for starches and chemically modified starch for application in the paper, textile and foodindustry, for personal hygiene products like shampoo, creams, and for paints.

PHYSICAL CHEMICAL PROPERTIES
1,5-Pentanediol is a colorless and odorless liquid at room temperature.

Melting point/range: ca. -16 °C
Boiling point/boiling range: 238 °C at 1013.25 hPa
Decomposition temperature: Not determinedFlashpoint: 142 °C (closed cup)
Flammability (solid, gaseous): Not flammable upon ignition
Selfignition temperature: 330 °C
Explosion limits:Lower: 1.3 %Upper: 13.2 %Explosive properties: Non explosive.
Molecular weight: 104.1476 g/mol
pH value: 7.6 at 20 °C and 500 g/l
log Pow: -0.49 at 25 °C
Vapor pressure: 0.0052 hPa at 25 °C
Relative density: 0.985 g/cm3 at 25.2 °C
Solubility in/Miscibility with water: Miscible in any ratio at 20 °C
Oxidizing properties: No oxidizing properties

HEALTH EFFECTS
1,5-Pentanediol has no marked health hazard properties. Its acute toxicity is very low via all routes of exposure
tested (oral, skin and inhalation). It has no irritation or sensitization effects. Limited repeated dose and longterm health or reproductive effects has been generated with 1,5-Pentanediol itself. More extensive data isavailable for the analogous substance 1,5-Hexanediol. Based on the total amount of information available
1,5-Pentanediol is not expected to cause repeated dose or long term health effects. The physical properties of
1,5-Pentanediol give no rise to concern. Its flammability is low. Therefore, 1,5-Pentanediol has a very low
overall human health hazard potential.

EFFECT ASSESSMENTRESULT

Acute Toxicity (oral/dermal/inhalation)

1,5-Pentanediol is of low acute toxicity via all routes ofexposure.

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Irritation/Corrosivity

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1,5-Pentanediol is not irritating to the skin or to the eyes.

(skin/eye/respiratory tract)

Corrosivity was not tested on the basis of the absence ofirritation properties.

Sensitization

Based on the available data, 1,5-Pentanediol is not considered(skin/respiratory tract)

to have skin or respiratory sensitization properties.

Mutagenicity

All available in vitro test data on 1,5-Pentanediol and theanalogous 1,6-Hexanediol indicates that bioaccumulation is
not expected.

Carcinogenicity

No carcinogenicity data has been generated due to thenegative mutagenicity results.

Reproductive Toxicity

Screening test information with the analogous 1,6-Hexanediolsuggests 1,5-Pentanediol should have no adverse
reproductive effects either.

Repeated Dose Exposure

Oral repeated dose test results with an analogous substance(1,6-Hexanediol) suggest that no marked toxicity should beexpected. Dermal and inhalation repeated dose exposure
testing is considered unnecessary based on expected
exposure routes and the oral repeated dose test result.

ENVIRONMENTAL EFFECTS
The results of all three acute aquatic studies on fish, algae, plants and invertebrates indicate a low
environmental acute hazard potential for 1,5-Pentanediol. 1,5-Pentanediol is readily biodegradable and it has avery low bioaccumulation potential. Considering all available data on biotic and abiotic degradation,
bioaccumulation and toxicity, it can be stated that the substance is neither persistent nor toxic to theenvironment and that it will not bio-accumulate. Overall 1,5-Pentanediol has a very low environmental hazard
potential.

EFFECT ASSESSMENTRESULT

Aquatic Toxicity

Fish, daphnia, algae and plants studies indicate that theaquatic toxicity of 1,5-Pentanediol is low.

FATE AND BEHAVIORRESULT

Biodegradation

1,5-Pentanediol is readily biodegradable, based on test resultswith 1,5-Pentanediol itself and analogous substances(1,6-Hexanediol and Butanediol).

Bioaccumulation potential

1,5-Pentanediol will preferentially distribute to water. Based on
the value of the partition coefficient it is concluded that3

1,5-Pentanediol
August 12, 2012
Version: 1bioaccumulation is not expected.
PBT/vPvB conclusion

Based on its low toxicity, bioaccumulation potential and readybiodegradability, 1,5-Pentanediol does not meet the criteria for
PBT or vPvB.

EXPOSURE
Human Health
1,5-Pentanediol is used in many different applications. In industrial sites it is used for the production ofhydrogen, hydrogen peroxide, sodium perborate and peroxyacetic acid. But its main industrial use is as
monomer or reactant, therefore, 1,5-Pentanediol will no longer be present as such in downstream products,
practically eliminating the exposure potential for professional users and consumers.
On the other hand, 1,5-Pentanediol is contained in formulated products of common use, such as adhesives,putties, sealing compounds, cleaners, paints and inks, synthetic resins and personal hygiene products(shampoo, creams, etc.). In all previous cases, 1,5-Pentanediol occurs in diluted form, so professionals andconsumers level of exposure will be very low.

Environment
1,5-Pentanediol is liquid at room temperature and it has relatively low volatility. The probability of release inpure form to any of the environmental compartments is low under normal industrial use conditions. There may
be some release to waste water streams as a result of normal use or industrial cleaning operations, but, as
1,5-Pentanediol is readily biodegradable, this should not cause further environmental exposure.

RISK MANAGEMENT RECOMMENDATIONS
1,5-Pentanediol poses very low human health and environmental risks. However, it is a good practice to train
personnel handling the substance and to protect workers who may be exposed to 1,5-Pentanediol by taking
the usual precautionary measures to protect against chemical exposure. Therefore, protective clothing, gloves
and safety glasses with side shields should be worn when handling this substance. Good ventilation is requiredin areas where 1,5-Pentanediol is handled. Respiratory protection is not required unless 1,5-Pentanediol isreleased in the form of gas or in the form of aerosols. 1,5-Pentanediol is not flammable, however, it is a goodpractice to prevent the build-up of electrostatic charge when storing it.
For environmental protection in case of accidental release: do not allow product to reach sewage system or
any water course. Retain and dispose of contaminated wash water.

STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
1,5-Pentanediol is included in the OECD list of High Production Volume (HPV) chemicals, but a SIDS is not yet
available.
1,5-Pentanediol is listed in the following Chemical Inventories: AICS, NZIoC, KECI, PICCS, IECSC, EINECS,4

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Canada DSL, TSCA, ENCS.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Not classified.

Labeling according to REGULATION (EC) No 1272/2008:
Pictogram: none
Signal word: none
Hazard statements: none

CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company: UBE Industries, Ltd.
Department: Fine Chemicals Business Unit
Address: Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo
Town/Country: Japan
Postal code: 105-8449
E-mail: ube-fine@ube-ind.co.jp

Additional information can be found at:
http://www.ube.co.jp

GLOSSARY
Acute toxicity

Harmful effect resulting from a single or short term exposure to asubstance.

AICS

Australian Inventory of Chemical Substances.

Biodegradation

Decomposition or breakdown of a substance under natural
conditions (actions of micro-organisms etc).

Bioaccumulation

Progressive accumulation in living organisms of a chemical
substance present in the environment.

Canadian DSL

Domestic Substances List of Canada.

Carcinogenicity

Substance effects causing cancer.

CAS

Chemical Abstracts Service (division of the American ChemicalSociety).

Chronic toxicityHarmful effect after repeated exposures or long term exposure to asubstance.

5EINECS

1,5-Pentanediol
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European Inventory of Existing Commercial Chemical Substances

ENCS

Existing Notified Chemical Substances (Japan).

Flash point

The lowest temperature at which vapor of the substance may form
an ignitable mixture with air.

Genotoxicity

Substance effect that causes damage to genes, including
mutagenicity and clastogenicity.

GHS

Globally Harmonized System of Classification and Labeling ofChemicals

HPV

High Production Volume Chemicals.

Hydrolyze

Undergo hydrolysis; decompose by reacting with water.

IECSC

Inventory of Existing Chemical Substances Produced or Importedin China.

Intermediate

Substance that is manufactured for and consumed in or used forchemical processing in order to be transformed into anothersubstance.

KECI

Korean Existing Chemical Inventory.

Monomer

Means a substance which is capable of forming covalent bonds
with a sequence of additional like or unlike molecules under theconditions of the relevant polymer-forming reaction used for theparticular process.

Mutagenicity

Substance effect that cause mutation on genes.

NZIoC

New Zealand Inventory of Chemicals

PBT

Persistent, bioaccumulative, toxic chemical.

Persistence

Refers to the length of time a compound stays in the environment,
once introduced.

PICCS

Philippine Inventory of Chemicals and Chemical Substances.

Risk Management Measures

Engineering controls, conditions and protective equipment needed
to be implemented to ensure that the risks to human health and theenvironment are adequately controlled.

REACH (EC) No. 1907/2006

European Commission Regulation concerning the Registration,Evaluation, Authorization and Restriction of Chemicals.

REGULATION (EC) No 1272/2008

European Commission Regulation on Classification, Labeling andPackaging of Substances and Mixtures.

Reproductive toxicity

Including teratogenicity, embryotoxicity and harmful effects onfertility.

Sensitizing

Allergenic.

Sediment

Topsoil, sand and minerals washed from land into water forming in6

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the end a layer at the bottom of rivers and sea.
TSCA

Toxic Substance Control Act (USA).

Vapor pressure

A measure of a substance’s property to evaporate.

vPvB

Very persistent, very bio-accumulative.

DISCLAIMER
This information is furnished without warranty, expressed or implied, except that it is accurate to the bestknowledge of UBE INDUSTRIES, LTD. The data on this sheet related only the specific material designatedherein. UBE INDUSTRIES, LTD. assumes no legal responsibility for use or reliance upon these data.

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