Mission of the Nagoya University School of Medicine

To develop cutting-edge medical research that will contribute to an improvement in thehealth of mankind and to create new medical technology.

To develop an open system to utilize sources of talented people which can serve as the
hub for medical research and medical care.

To enhance the quality of local medical services in cooperation with local institutions,both in medical research and medical care, and to improve medical care standards inJapan and the world.

To foster medical researchers and medical professionals who respect medical ethics, andtake pride in contributing to the welfare of mankind.

Logo
A combination of three cranes, symbolizing love (humanity), harmony (partnership),and honesty (good faith) respectively.
This symbol represents the essence of healing and diligent medical study
that physicians must embrace and hand down to the next generation.

Mission of the Nagoya University School of Medicine

02 Greeting
05 Special Topics
06

Nurturing of Young Researchers

08

Center for Advanced Medicine and Clinical Research

10

Nagoya University Clinical Simulation Center (NU-CSC)

12

Program in Integrated Medicine

14

Enhancement of International Exchange 1)

16

Enhancement of International Exchange 2)

18

Enhancement of International Exchange 3)

20

Center for Neurological Diseases and Cancer

22

Brain and Mind Research Center

24 History

3-2014
Contents
The “M” in “PROFILE M” stands
for diverse ideas including“Medicine”, our “Mission”, andthe “Midland” region where ourfacilities are situated.

26 Past deans
27 Education/research organization
28 Organizational chart
29 Executives
30 Tsurumai Campus
32 Graduate School of Medicine
32

Doctoral Course (Medical Sciences)36

Researcher Course(MD/PhD Course, Direct Postgraduate Course)

37

Affiliated Laboratories

38

Endowed Chair

42

Master’s Course

44 School of Medicine
45 University facilities
47 Daiko Campus
48 Graduate School of Medicine
50 School of Medicine
51 Data
69 Locations

Published October 2013
Prepared and edited byGeneral Affairs & Planning Section, General Affairs Division
Nagoya University School of Medicine and Graduate School of Medicine
TEL: +81-52-744-2228

Greeting

TAKAHASHI, Masahide

Dean of the School of Medicine and Graduate School of Medicine

Upon the publication of the 2013-2014 Profile of the Nagoya University School of Medicine and Graduate
School of Medicine, I am honored to have this opportunity to say a few words of greeting.
The Nagoya University School of Medicine was originally founded in 1871 by the Nagoya feudal clan as atemporary hospital and temporary medical school. With a history and traditions stretching back 140
years, it is one of the oldest medical schools in Japan. In 1939 the University became the seventh Imperial University in Japan, with faculties of medicine and science and engineering. In 1949, after World War
II, it was restarted as Nagoya University under a new education system.
In 1997 the Department of Health Sciences was established; the School of Medicine thus came to comprise two faculties, Medicine and Health Sciences. Then, in 2000, Nagoya University completed organizational strengthening of its graduate schools and, as a graduate university, it restructured the Graduate
School of Medicine by reorganizing the basic and clinical medicines into four research fields: Integrated
Molecular Medicine, Cell Information Medicine, Function Construction Medicine and Health & Community Medicine. In this school year, these four programs have been merged into one program named theProgram in Integrated Medicine, in which three divisions, the Division of Basic Medicine, the Division ofClinical Medicine, and the Division of Clinical Pharmacology, have been established. For the Division ofClinical Pharmacology, we have just launched two new disciplines, Biostatistics and Toxicogenomics, toenhance drug discovery and clinical medicine research. Additionally, in the Division of Clinical Pharmacology, we are offering some new joint sub-divisions in order to strengthen the development of individuals with potential capability in drug discovery and those with the ability to accelerate clinical trials, because this is an area in which Japan lags behind other countries. These sub-divisions include one
developed under an industry-academia collaboration in cooperation with pharmaceutical companies including Novartis Pharmaceuticals Japan and Astellas Pharma Inc., one jointly organized with Meijo University Graduate School of Pharmacy, and one with the Institute of Statistical Mathematics and the Pharmaceuticals and Medical Devices Agency.
Simultaneously with the reorganization of the Graduate School of Medicine as described above, we are
improving the facilities that support the basis of our education and research, as a result of which the construction of the Graduate School of Medicine’s research building No. 3 will be completed during thisschool year. This building will include an anatomy training room for students, a histological/pathologicaltraining room, a radioisotope center, and a common-use equipment center. The building will also provide
space for various project-based studies, including those conducted by endowed chairs and by industry-academia collaborative sub-divisions. Biostatistics and Toxicogenomics, the new disciplines which will be established in the Division of Clinical Pharmacology as mentioned earlier, will also be housed in building No.
3, thus improving our education and study environment.
As one of the major missions of the Graduate School of Medicine this year, we intend to accelerate theinternationalization of the institution at the research level. Following the symposium organized with theMedical University of Vienna in January 2013, we held another symposium at the University of Adelaidein Australia in May. These were attended by many research scientists from the Graduate School of Medicine, thus deepening our mutual relationships with the two universities. Since international joint studies
will increasingly be required in the future, we intend to organize similar symposiums on a regular basis.
We aim to have a School of Medicine and Graduate School full of vitality, and intend to put all possible
effort into achieving this. We appreciate your advice and guidance.
02

P r o f i l e M 2 013-2014

SAKAKIBARA, Hisataka
Head, School of Health Sciences
Director, Graduate School of Medicine (Health Sciences)
The Nagoya University School of Health Sciences was established in 1997 as one of the few schools of
health sciences in Japan which consists of five departments: nursing, radiological technology, medical
technology, physical therapy, and occupational therapy. The school has a history of more than 100 years,
originating from a training school for nurses which was founded in Aichi Medical School in 1894. The institute was strengthened as an educational research organization centered on the graduate school in
April 2012. Since then, as the Graduate School of Medicine comprised of the departments of nursing, radiological and medical laboratory sciences, and physical and occupational therapy, we have enhanced our
educational research activities.
In today’s medicine, the highly advanced medical technology is developed remarkably, and there are also
increasing needs for comprehensive healthcare and welfare focusing on the quality of life (QOL) of patients and their families, such as palliative care and terminal care. Better education and research inhealthcare is a social necessity in the declining birth rate and the ageing society. Nagoya University, in
addition to training skilled human resources who will play a leading role in healthcare in the future, aims
to expedite healthcare research and hence further progress in healthcare in the 21st century.
Nagoya University instituted the Training Course for Total Health Planners (THP) (designated as a Good
Practice in 2007 by the Ministry of Education, Culture, Sports, Science and Technology (MECSST)), a
unique initiative for human resource development with a view to expanding team medical care performed by interprofessional collaboration. In the 2012 school year, we further restructured the curriculum of the graduate school’s common education into a cross-department system to improve the educational program offered at the school.
To develop specialists in today’s highly advanced medical technologies, we established a certified nurse
specialist (CNS) training course to develop oncology nurse specialists and pediatric nurse specialists and,in accordance with the Foundation Enhancement Plan for Training Oncology Professionals designed by
the MECSST, we train oncology nurse specialists, radiology technologists who specialize in radiation
therapy, and physicists in medicine. Additionally, in line with the MECSST’s objective of establishing astronger system for training nurses, we have been improving our human resource development as wellas educational research in collaboration with Nagoya University Hospital.
In addition, for the internationalization of education, we launched an international exchange programwith the Department of Health Sciences/Nursing of Yonsei University in Korea in 2010, in which academic research meetings are held alternately at each university every year. In 2011, a program was commenced among Yonsei University, Shanghai Jiao Tong University, National University of Singapore, andourselves to accept each other’s undergraduates for clinical nursing training.
Regarding research, following the establishment of the Brain & Mind Research Center in 2011, we will
accelerate studies utilizing magnetic resonance imaging (MRI) and magnetoencephalography (MEG). In
the 2012 school year, we started to participate in the Innovative Research Center for Preventive Medical
Engineering—a center for collaboration among medical engineering, industry, and academia—to broaden
the range of our research projects.
The alumni from our institute are now active in various medical and educational organizations and arepotential future leaders. We will continue to develop our educational research in the health sciences andthus contribute to the progress of modern healthcare.
03

Tsurumai Campus: Medical Science Research Building 1 and 2

Nagoya University Hospital

Daiko Campus: Main Building of School of Health Sciences

Special Topics
Aiming to Build a World-leading Center for
Outstanding Research and Education
As an international research university, the Nagoya University Graduate School of Medicine andSchool of Medicine are actively carrying out international initiatives to develop human resources
as a social responsibility. We are also working to
improve studies in integrated research fields andlarge-scale projects, strengthening the researchsystem and environment ranging from basic
through clinical, and returning the results of research to society. Our aim is to conduct worldclass academic research.
Of these initiatives, the latest activities are introduced here.
・Nurturing of Young Researchers

06

・Center for Advanced Medicine and Clinical Research

08

・Nagoya University Clinical Simulation Center (NU-CSC)

10

・Program in Integrated Medicine

12・Enhancement of International Exchange 1)

14・Enhancement of International Exchange 2)

16

・Enhancement of International Exchange 3)

18

・Center for Neurological Diseases and Cancer

20

・Brain & Mind Research Center

2205

Nurturing of Young Researchers“Nagoya University Student Association of Medical Research (LOVE LAB)”
KURODA, Keisuke, Extraordinary Assistant Professor
Nagoya University Student Association of Medical Research
Project for Development of Researchers in Basic Medicine

The Lack of Research Physicians: Another Aspect of
the Shortage of Physicians
In recent years, the nationwide shortage of physicians and the resulting collapse of healthcare services in local areas have caused growing concern. Although the shortage of clinicians including surgeons,pediatricians, obstetricians, and anesthesiologists has
been widely reported in the media, there has been
little attention on the falling number of physicians
engaged in research, especially in basic medicine.
Unfortunately there is now a serious shortage ofyoung physicians seeking to become researchers inbasic medicine. In the long term, this will cause adecline in the level of medical research in Japan,
and hence lower levels of healthcare, increased
healthcare expenses, and dwindling international
competitiveness of the drug discovery and medical
devices industries.
Leveraging the winning of the 2012 Nobel Prizein Physiology or Medicine by Professor Shinya Yamanaka of Kyoto University, we need to put muchgreater effort into encouraging researchers to boost
the number of research scientists who may follow
Professor Yamanaka’s achievements in basic medicine.

Exchange Meeting between Student
Researchers of the University of Tokyoand Kyoto University

Consortium
Kobe University

Initiatives at Nagoya University
In the 2011 school year, under the auspices of MECSST, Nagoya University launched a project jointlywith the University of Tokyo, Kyoto University, andOsaka University to train researchers in basic medicine. The project aims to produce a several researchers in basic medicine every year, through asystem for sending students overseas and for providing scholarships for going on to graduate school.
We also set up a consortium for nurturing researchphysicians to collaborate with other schools of medicine in the Tokai region. In the 2012 school year, theNagoya University Student Association of Medical
Research was launched to assist the project, inwhich a teacher in charge is assigned to guide andassist the students’research activities. In the same
year, the consortium for nurturing research physicians organized by six universities in the Tokai region held its first retreat. The Student Associationof Medical Research will continue its activities in
the 2013 school year.
Cultivating a Research Mind
Although medical care depends on advanced technologies, good medical care in the actual setting requires more than just detailed knowledge gained
from famous textbooks or treatment guidelines. We
need to doubt self-evident‘truths‘, understand back-Consortium for Nurturing Research Physicians Organizedby Four Universities in the Kanto area:
http://www.kt-mstp.umin.jp/

University of Fukui
Shiga University of
Medical Science

University of Yamanashi (Life Science Special Course)

Riken

Kyoto University
Program for Development ofResearchers in Basic Medicine●Laboratory rotation●Course meetings

The University ofTokyo

Gunma University
Chiba University (Program for Nurturing Research Physicians)

Program for Development of
MD Researchers●Free Quarter (FQ)
The 1st Retreat of 4 Universities (Tokyo)

Project for Development ofResearchers in Basic Medicine
Holding of retreats
Osaka University
Program for Development of
MD Researchers●Grades 1 and 2: Experience of the Basic Medicine Course●Grades 3 to 6: Assignment to the Basic Medicine Course

Kansai Consortium

Osaka City University
Okayama University
The University of Tokushima

06

P r o f i l e M 2 013-2014

Nagoya University
Student Association of
Medical Research●Seminar of Basic Medicine

Consortium for Nurturing
Research Physicians Organizedby Six Universities in the Tokai Region
Nagoya City University
Aichi Medical University
Mie University
Fujita Health University
Gifu University

grounds, and develop the ability to analyze experiences properly. In other words, we need to cultivatea ‘research mind’, which means a passion for exploring the unknown. The key to nurturing researchphysicians is to have as many students as possible
discover the joy and importance of doing research,with the whole School of Medicine sharing the same
research spirit. We hope that students seeking a career in research as well as the clinical field will experience research activities through this project anddevelop a research mind.
Activities of Nagoya University Student Associationof Medical Research
In the 2012 school year, Nagoya University launched
the Nagoya University Student Association of Medical Research (LOVE LAB) to develop young researchers. The Association is for undergraduates
and, as the name ‘Student Association’ indicates, participation is optional and at the students’ discretion,
just like other student group activities. The Student
Association offers the following two courses.

tents of their studies, to help students realize thejoy of conducting research and develop a researchmind. In addition, seminars are held to teach how toread scientific papers, how to design research plans,
how to perform experiments and so forth. For students wishing to conduct particular types of research, arrangements are made for them to tour research laboratories.
Advanced Course
This course is for undergraduates who are alreadyconducting research aiming to become researchphysicians. Monthly meetings to report on the progress of their research are held and financial support
is provided to help them attend domestic and overseas academic conferences and to visit research laboratories. Group retreats, including research presentations, are held to enhance exchanges with otheruniversities. For those who request it, arrangements
are made for joining the MD/PhD course or proceeding to the graduate school as early as possible
after graduation.

Basic Course
This course is for undergraduates who are interested in research. The professors of the School of Medicine talk about their research careers and the conProceedtoOrdinary
Graduate
SchoolYear 3 after
graduation

Year 1 after
graduation

National
Examination
for Medical
Practitioners

6th grade

Complete Early
Clinical Training

Year 2 after
graduation

Early ClinicalTraining

Practice ofClinicalMedicine*2

MD/ PhD
Course*1*1 Early completion in 3 years is possible
based on achievements.
*2 Continuation of the research is possible if
requested.
*3 Clinical practice is possible if requested.

Advanced Course(After joining a
Postgraduate Class)

Practice ofClinical Medicine

5th grade
Computerbased Testing

4th grade

Lecture on Clinical Medicine
Lecture on Social Medicine/ Practice
Basic Medicine Seminar

Basic Medicine Seminar

3rd grade
Basic Medicine
Lecture/Practice

2nd grade

1st grade

Basic Seminar
Introduction to
Medicine
Basic Biology I/II

General
Education

Ordinary Curriculum

Basic Course(Before Joining
a Postgraduate
Class)

Presentation of
Research Results/ Prepare a
Monograph

Graduate
SchoolCourse forDevelopment ofResearch
Physicians*1

National
Examination
for Medical
Practitioners*3

LatterClinicalTraining

Year 4 after
graduation

Basic
Research or
ClinicalResearch

ObtainPhD

Year 5 after
graduation

Obtain Qualification
as Specialist

Year 6 after
graduation
and beyond

Conclusion
When working hard through trial-and-error in
the world of research, there is a moment whena splendid idea comes up. If this idea leads to a
new discovery, the joy is unparalleled. This is
the true pleasure of research. We sincerely
hope that as many undergraduates as possible
will try doing research and experience the fun.
Project for Development of Researchers in Basic Medicine
Nagoya University Student Association of
Medical Research Home Page
http://med.nagoya-u.ac/nsam/index.html

Student Association of
Medical ResearchSpecial Topics

07

Center for Advanced Medicine and Clinical Research“Translational Research Support Center/Core Hospital for Clinical Research/Chubu Regional Consortium for Advanced Medicine”
MIZUNO, Masaaki, Clinical Professor
Center for Advanced Medicine and Clinical Research
Nagoya University Hospital

Support Center and is in charge of the process between basic research and ‘First-in-Human’ studies.
Meanwhile, the clinical research support section
primarily serves as the core hospital for clinical research, and conducts clinical research and trials after the First-in-Human studies. In the future, theeffort will be joined with the initiative of the Chubu
Regional Consortium for Advanced Medicine, andnew medical care in the Nagoya/Chubu region will
be developed for the world benefit.

The Center for Advanced Medicine and ClinicalResearch of Nagoya University Hospital supports
the entire process from searching for ideas throughto medical treatment covered by health insurance,
based on its vision, “contributing to society throughmedical treatment, education, and research”, and its
basic principle, “developing new medical services
for the next generation”.
In 2012, Nagoya University Hospital was chosen
for the Translational Research Network Programof the Ministry of Education, Culture, Sports, Science and Technology (MECSST) and the Project
for Establishing Core Hospitals for Clinical Research of the Ministry of Health, Labour, and Welfare (MHLW). Thus, the functions as the Translational Research Support Center and the core
hospital for clinical research were added, and boththe quantity and quality of advanced medical development conducted in the hospital were improved.
We have now separated the functions in the centeras follows. The advanced medicine support section
primarily serves as the Translational ResearchCenter for Advanced Medicine and Clinical Research
Nagoya University Intellectual
Property Section

Director
Graduate School of Medicine

OperatingCommittee
Collaboration

Advanced Medicine Support Section■Translational Research Network Program (MECSST)
In this program, the university hospital serves as a
network hub in the Chubu area for developing advanced medicine through the following three projects.

1)Establish a center for translational researchWith a project manager as a leader, the Design
Buildup Team comprised of a clinical epidemiologist, biostatistician, patent attorney, data manager,
monitoring/audit manager, clinical research coordinator and so forth carries out
strategic development of adEthics Committee
vanced medicine, in close contact with health authorities.

Clinical Research Support Section

Integrated Process from the Discovery of New Ideas to their Advancement into Insurance-covered Medical Care

Base for Supporting Translational ResearchCore Hospital for Clinical Research(MECSST)(MHLW)

Support basic research through First-in-Human studies

Support basic research developed into First-in-Human studies

Structure of the Center for Advanced Medicine and Clinical Research
Valley of Death

Traditional Development of Advanced Medicine

Exploration of
Ideas
University Staff(Physicians/Researchers)

Development of Ideas
Translational Research (TR)
Preclinical Study

Matching Interests
with Private Companies

Clinical Trials

Formation of Development Team

Sponsor-Initiated Trials

Clinical Study

Fundraising(several hundred million yen – several billion yen)

Medical Treatment Covered
by Health Insurance(Commercialization)

Investigator-Initiated Trials

Substantial Investment in Human Resources

Strategic Approach of Nagoya University Hospital
Effective Utilization of Funds
Advance Approach to the Health Authorities

Exploration of Ideas
Project Manager

Matching Interests
with Private Companies
Preparations/Devices
Set Objectives

Valley of Death

Development of Ideas
Translational Research (TR)

University Staff
Preclinical Study(Physicians/Researchers)
Company Personnel Approach to the Health Authorities
Patent Attorney
Health Care Workers, etc. Strategic Research

Clinical Study

Clinical Trials
Sponsor-Initiated Trials

Medical Treatment Covered
by Health Insurance(Commercialization)

Investigator-Initiated Trials

Formation of Development Team
Design Buildup Team

Design Buildup Team and Strategic Development of Advanced Medicine08

P r o f i l e M 2 013-2014

2)Reinforcing the center’s ability to develop ideas
To encourage the developmentof ideas, a system for collecting
and administering new information is established within theuniversity hospital to integrate
such information throughout
the Chubu area and control the
progress of the initiative.
3)Establishment of a permanent center for translational
research
We will establish a system toprovide the university and other institutes with the servicesof the Site Management Organization (SMO). To ensure theindependence of the organization, revenues from the hospitalwill be continuously reinvested
into translational research toensure a balanced budget regarding our services.

■Clinical Research Core Hospital Program (MHLW)In this project, a clinical research enhancement system in compliance with international standards is
implemented by the hospital as a whole through thefollowing four initiatives. This will accelerate practical application and commercialization of research
objectives, enabling Japan to take international leadership in the development of advanced medicine.
1)Sustainable search and development of new ideas
We will build a system for carrying out the sustainable search and development of promising new
ideas.
2)Education of clinical researchers
We aim to train physicians who can develop ideas andthose who have management skills, as well as otherpersonnel with a broad range of skills, to link academic‘intelligence’ to ‘socioeconomic value’, and thus encourage interoccupational collaboration.
3)International standardization as the center forclinical research development (ICH-GCP)
Upon implementing the project for advanced medicine in compliance with the ICH-GCP standards, we
aim to achieve 100% compliance with the ICH-GCP
within 5 years in clinical studies that are conductedin the university hospital. In addition, we are improving the follow-up of serious adverse events andthe support system for patients and their families.
4)Practical application and commercialization ofprospective ideas
Utilizing the network among the Nagoya-University-associated hospitals, which is one of the most ex-tensive inter-hospital networks in Japan, and withthe broad clinical research field offered by the Chubu Regional Consortium for Advanced Medicine,
we have created a database for patient enrollment
and are strengthening strategic clinical research
focusing on clinical trials. We also utilize information and communication technology (ICT) and havebuilt electronic infrastructure that enables us todeal with the Food and Drug Administration (FDA)
in the United States and other such organizations.
■Chubu Regional Consortium for Advanced Medicine
The Chubu Regional Consortium for Advanced Medicine consists of eight institutes: the seven universities of Aichi Medical University, Kanazawa University, Gifu University, Nagoya City University, Nagoya
University, Fujita Health University, and Mie University, and the National Center for Geriatrics and Gerontology. It was established with the objective ofbuilding collaboration system among universities in
the Chubu area for the rapid development of new
medical technologies and devices which meet society’s need, and their delivery to patients as fast as
possible, to contribute to the health and peace of people in Japan and worldwide. To achieve this objective, the organization is focusing on the following initiatives: 1) planning, adjustment, implementation, andevaluation of multi-center clinical studies, 2) hostingof joint ethical review board meetings, 3) nurturing of
human resources for developing advanced medicines,
and 4) support for matching interests with privatecompanies for industry–academia collaboration andadministration of intellectual property.

Inter-hospital Network among Hospitals associated with Nagoya University(One of the most extensive associated-hospital networks in Japan)

34 large-scale institutions with 500+ beds eachMore than 20,000 beds

Broad Fields of Clinical Research
Forum of New Healthcare Industry
Chubu Regional Consortium for Advanced Medicine

Chubu Regional Network for Industrialization of Medicine(Network among 7 university hospitals in Chubu area + 1 center)(Network among medical-related companies in Chubu)
Nagoya University Hospital

Medical Devices Industry Promotion Association

Center for Advanced Medicine
and Clinical Research
Universities and hospitals
in Japan and abroad

Research institutes
in Japan and abroad(Nagoya Chamber of Commerce & Industry)

Aichi Medical University Base for Supporting Translational Research
Kanazawa University
Core Hospital for Clinical Research
Other companies
Gifu University
Chubu Bureau of Economy,
in Japan and abroad
Nagoya City University
Trade and Industry
Nagoya University
Chubu Economic Federation
Fujita Health University
Nagoya Chamber of Commerce & Industry
Mie University
Pharmaceuticals andChubu Medical Devices Manufacturers
Medical
Devices
AgencyAssociation
National Center for Geriatrics(PMDA)and Gerontology
Administrative organs, etc.
MHLW

Joint Development with Academic Ideas

Enhancement of Practical Application
with Industry Ideas

To Deliver New Medicine Developed in Nagoya/Chubu to the WorldNew System for Development of Advanced Medicine by Industry-Academia-Government Collaboration
Special Topics

09

Nagoya University Clinical Simulation Center (NU-CSC)“Profile of Nagoya University Clinical Simulation Center (NU-CSC)”UEMURA, Kazumasa
Professor, Medical Education, Graduate School of Medicine
Director, Nagoya University Clinical Simulation Center

Nowadays, effective clinical education often involves practicing medical procedures using manikins instead of patients or equipment (simulators)
which imitates parts of the living body (a central
vein in the neck, bronchi, cubital veins and so forth).
Various models simulating real medical settings arealso widely used in programs to teach team medical treatment (full-scale simulation training). The
pedagogic effectiveness of this approach is recognized irrespective of job category. Previously, thenorm was on-the-job training, i.e. learning-by-doing,in which students proceed in order of lectures, observation, and then practice. However, this approach is no longer accepted in contemporary society.
Opening of Nagoya University Clinical Simulation
Center (NU-CSC)
Nagoya University launched the Skills & IT Laboratory (“Skill Lab”) in 2006. In addition to simulatorsof emergencies and resuscitation which are used in
lectures on Basic Life Support (BLS) and Advanced
Cardiovascular Life Support (ACLS), the laboratory
is equipped with ophthalmoscopes, otoscopes, andother instruments for training in performing sutures, intravenous injection, rectal examination,breast palpation and so forth. These are used by atotal of 20,000 students, medical interns, newly-employed nurses, and young physicians, nearly 2,000
trainings annually. However, the institute had almost no simulators or training machines for surgical treatment, which had long been awaited because simulation training using such equipment
prior to actual clinical practice is crucially important.
Accordingly, a large sum was budgeted in the2012 budget request, enabling us to obtain manystate-of-the-art simulators and training machines
mainly for surgical treatment, which led to thelaunch of the Clinical Simulation Center (NU-CSC)
which encompassed and developed the functions of
the Skill Lab. Some of the most advanced simulators are outlined below.

10

P r o f i l e M 2 013-2014•

Endoscopic Surgical Simulator
The simulator for laparoscopic surgical training
provides simulated vision and tactile sensation of
actual laparoscopic procedures by the most advanced technology. Apprentices can learn surgical procedures and how to handle complications
and so forth as if it were real.

•

Ultrasound and Endoscopic Simulator
The transesophageal/transthoracic echocardiographic simulator provides effective support for
the training of diagnostic image reading skills including knowledge on anatomy and pathology
which are necessary for cardiac ultrasound imaging and hand-eye coordination by probe-handling.

•

Simulator for Intravascular Surgery
The Endo Vascular Evaluator (EVE), a simulator
for high-precision intravascular surgery, was developed by a venture company, FAIN-biomedical
Japan, which was founded by Nagoya University.

This device reproduces blood vessels in thewhole body including brain arteries, coronary arteries, hepatic arteries, and renal arteries basedon data obtained by actual computed tomography (CT).
In addition to the basic operation of catheters,
it can realistically replicate various procedures
including aneurysm embolization, vasodilation,
stent placement, recanalization of thrombus, andHigh-precision Intravascular Surgery Simulator for Medical Training/Evaluation

The NU-CSC was established by encompassing the
Skill Lab, and two teachers and two employees
were assigned specifically to the institute. As technologies and skills become more advanced, moredetailed preparations are required to ensure safe
medical treatment. The range and quality of theequipment and instruments installed in the centerare of the highest level in Japan.
Future Direction of NU-CSC Activities•

Collaboration with regional medical education
institutes and medical institutions
NU-CSC is improving the educational programfor students at the School of Medicine and the
School of Health Sciences (five departments including nursing) of Nagoya University, as well as
medical residents and young physicians of the
Nagoya University Hospital. We will also continue to implement, in collaboration with regional
universities, medical institutions and so forth,various initiatives to contribute to the postgraduate and lifelong training for healthcare personnel
who are enployed in regional healthcare services,
as well as to the education of medical residents
and development of specialist physicians.

•

Enhancement of education for interprofessional
collaboration
Education using simulators is extremely effective
to learn interprofessional collaboration. Although
the importance of such collaboration has long
been recognized, it is only recently that a practical education program was developed. The NUCSC will develop various programs based on accumulated experience for the future.

•

Potential development of medical devices
The sophisticated simulators recently installed
are based on extremely detailed data on the human body and clinical data. The data obtained
from using these simulators may thus lead to thedevelopment of medical devices in the future.
Since the collection of experimental data in actual clinical practice is not easy due to ethicalreasons, such data may open up new channels forlinking industry and academia.

angiography.
•

Sensory Organs Simulator
The virtual ear/nose/throat (ENT) surgical simulator is for surgical training mainly for the middle
ear. It re-creates a 3D model of the cranium on
the screen from high-resolution data, enabling
the trainees to get a sense of touch very similar
to actual surgery by using a force-feedback function. Since the simulator can be loaded with individual CT data of patients, users are able to rehearse for each patient prior to surgery.

Special Topics

11

Program in Integrated Medicine“Unification into a Single Program Encompassing Integrated Medicine and Pharmaceuticals”
KADOMATSU, Kenji
Professor, Molecular Biology
Graduate School of Medicine

Profile of the Unification into One Program
To understand the increasing diversification andsophistication of medicine and to nurture true leaders in the world of medicine and medical research,
it is essential to promote both specialized education
in a particular research field and integrated education across various research fields. Although separate efforts were made in the four research fields tointegrate basic medicine and clinical medicine, theintegration was slow due to systemic issues.
Meanwhile, looking back on the recent trends inthe pharmaceutical R&D, advances have been
made in pathological diagnostics at the molecularlevel in various fields including cancer, nerves, cardiovascular system, and metabolism. As a result,molecular-target therapy based on pathology is rapidly becoming the main form of the pharmaceutical
R&D. Nowadays, no pharmaceutical R&D is possible without medical knowledge and insight. AcFig. 1
cordingly, the integrationof medicine and pharmaceuticals is becoming increasingly important. The
Nagoya University Graduate School of Medicine
Fig. 1already has, besides basic medicine and clinicalmedicine, an initiative for the pharmaceutical R&D.
However, although it is yielding excellent results inindividual studies, there was no system to expedite
the initiative as the Graduate School of Medicine asa whole.
We thus identified the need to add a new division,
Clinical Pharmacology, to Basic Medicine and Clinical Medicine and to restructure them into a unified
program that organically merges the three fields.
Thus, the former four fields were unified into a single program to enhance the interdisciplinary flexibility of students. We also launched multiple curriculums according to the specialities of the humanresources to be developed, to achieve an integrated
education (Fig. 1 and Fig. 2).
Supporting Organizations
For the Program in Integrated Medicine, we established a unique network including government organizations, companies, and Meijo University in addition to Nagoya University Hospital, Research

Program in Integrated Medicine, Graduate School of Medicine, Nagoya University
The former four programs were reinforced and restructured in the 2013 school year to create the unified Programin Integrated Medicine.

Program in Integrated
Molecular Medicine
Program in Cell
Information Medicine

Unification intoa single program

Program in Integrated Medicine

From 2013 school year

Program in Function
Construction Medicine
Program in Health& Community Medicine
Fig. 2

Fig. 2

Structure of Nagoya University Graduate School of Medicine

Program in Integrated Medicine
Division of Clinical Medicine

Division of Basic Medicine
Field 1

Field 11

Field 1

Field 11

Field 2

Field 12Field 2

Field 12Field 3

Field 13

Field 3

Field 13

Field 4

Field 14

Field 4

Field 14

・

・

・

・

・

・

・

・

・

・

・

・

Achieve Integrationof Education
Nagoya University School of Medicine Companies/University Hospital/ Research(Joint Lectures)Institute of Environmental Medicine

Government Organizations(Joint Lectures)

Field of Molecular Pharmacology

Field of Pharmaceutical R&D

Field of Pharmaceutical Management

Department of Molecular Pharmacokinetics

Department of Practical Pharmaceutical R&D

Department of Mathematical Statistics

Department of Molecular Pharmaco-Biology

Department of Applied Pharmaceutical R&D(The Institute of Statistical Mathematics)

Department of Toxicogenomics(Novartis Pharmaceuticals Japan and Astellas Pharma Inc.)

Field of Clinical Pharmacology
Department of Clinical Pharmacy
Department of Clinical Oncology and Chemotherapy
Department of Biostatistics
Department of Regulatory Science of Pharmaceuticals (Pharmaceuticals and Medical Devices Agency (PMDA))Division of Clinical Pharmacology

12

P r o f i l e M 2 013-2014

Institute of Environmental Medicine, associatedhospitals, and overseas affiliated schools. Furthermore, the Program in Integrated Medicine is working closely with the Graduate School of Pharmaceutical Sciences established in Nagoya University in2012, which is supported by the Graduate School of
Science, Graduate School of Engineering, and Graduate School of Bioagricultural Sciences, forming an
extensive network covering the entire university.
Through these networks, we will accelerate drug
discovery and improve the study of medicine (Fig. 3).

Fig. 3Fig. 3

Conceptual Organization Chart

Meijo University
Facultyof Pharmacy

Collaboration

Nagoya University HospitalCenter for Advanced Medicine
and Clinical Research
Departmentof Clinical Oncology
and Chemotherapy

Meijo University
Graduate Schoolof Pharmacy

Departmentof Hospital
Pharmacy

Clinical
Departments

Graduate Schoolof Science
Collaboration

Collaboration

Division of Basic Medicine
Division of Clinical Medicine
Divisionof Clinical Pharmacology

Research Instituteof Environmental Medicine

Collaboration

Graduate Schoolof Engineering

Main Fields

Collaboration

Graduate Schoolof Pharmaceutical
Sciences

Joint Lectureswith Companies

Government Organizations(PMDA, etc.)

Collaboration

Companies(Novartis, Astellas, etc.)

Collaboration

Joint Lectureswith Government Organizations
Collaboration

Graduate School of Medicine(Program in Integrated Medicine)

Graduate Schoolof Bioagricultural
Sciences

Collaboration

Associated hospitals, etc.
Collaboration

Overseas affiliated schools, etc.

Approach and Features of the Curriculum Design
In the first and second years after admission, thestudents study common basic subjects to learn basic research methods and acquire knowledge. In addition, they take special subjects to receive special
education in specific fields, and integrated education. In addition to the common (basic) subjects andthe special subjects, unique programs are also available for the students (Fig. 4).
１．Common (Basic) Subjects: Common subjects to acquirea broad basic knowledge as part of the education provided by the graduate school. These subjects include
Special Lectures on Medical Science and the Practiceof Basic Medical Science (Basic Training).
２．Main Subjects: Core subjects for the students to carryout research in their special field and to become creative researchers/medical trainers. These subjects include Special Seminars and Special Experimental Research.
３．Minor Subjects: Subjects which are relevant to themain subjects and useful for acquiring a comprehensive understanding of developments in broad areas of
medicine and healthcare. These subjects include Minor
Special Seminars.
４．Unique Programs: These programs support the uniquedevelopment of human resources of the graduate
school through a series of lectures or practicals basedon academic frameworks.

Fig. 4

Fig. 4

Education Curriculum for the Program in Integrated Medicine
Special Subjects
Common (Basic) Subjects
Main Subjects
Special Lectures on Medical Science(2 credits)

Special Seminars(10 credits)

Practice of Basic Medical Science(Basic Training) (2 credits)

Special Experimental Research(6credits)

Total 4 credits

Minor Subjects
Minor Special Seminars(10 credits)

Total 16 credits

Optional Total 10 credits

Requirements for completion:
30 credits or more in total
Submission of a thesis

A doctorate (Medicine)

Details 1. Common (Basic) Subjects: Common subjects to acquire a broad basic knowledge as part of the education provided by the graduate school
2. Main Subjects: Core subjects for the students to carry out research in their special field and to become creative researchers/medical trainers
3. Minor Subjects: Subjects which are relevant to the main subjects and useful for acquiring a comprehensive understanding of developments in broad areas of medicine and healthcare
4. Unique Programs●Program of Neuroscience: Lectures on neuroscience●Program of Cancer Science: Lectures on cancer science●Program for Developing Cancer Professionals: Lectures on chemotherapy and radiation therapy for cancer●Industry-Government-Academia Joint Program: Lectures based on the collaboration with government organizations, pharmaceutical companies and so forth●Program of Clinical Pharmacology: Lectures based on collaboration with Meijo University Graduate School of Pharmacy●On-the-Job Training Program: Practical field training at Nagoya University Hospital, Center for Advanced Medicine and Clinical Research, and other hospitals●Program of Translational Research: Lectures to grasp the situation of Bench-to-Bedside and to design strategies●Program of Medical English: Lectures to acquire English skills required for medical and pharmaceutical researchSpecial Topics

13

Enhancement of International Exchange 1)“International Symposiums”
KASUYA, Hideki, Associate Professor in charge of special education forforeign students, Graduate School of Medicine
Director, Office of International Affairs

As a research-focused university, the Nagoya University Graduate School of Medicine is striving not
only to produce excellent human resources and install advanced equipment but also to create an international research environment for conducting
world-leading research. The international symposiums organized with our affiliates, which areamong the world’s leading medical schools, arepart of the process of building an international research environment.
Aiming to identify ideas for joint research and to
improve education in the doctoral course, these international symposiums held between the schoolsof medicine are open not only to researchers but
also to graduate students and facilitate cross-border international exchanges. The first international
symposium was held at the Center for Brain Research, Medical University of Vienna in January
2013. The purpose was to understand the contentsof the research—especially that on neurological disorders and cancer—ongoing at the Medical University of Vienna and the Nagoya University Graduate
School of Medicine; 14 participants from both institutes gave presentations of their studies to help
each other understand the research in progress,
and to develop it into joint-research opportunities.
The symposium was attended by some 100 participants comprised mainly of researchers and graduate students from the Medical University of Vienna.
The presentations were also video-recorded to enable those who could not attend on the day to review the contents later. Visits to the research laboratories in related fields were also arranged the day
after the symposium to discuss the future directions of studies.

The Medical School of Vienna

Up to a few years before the symposium, theMedical University of Vienna had been part of the
University of Vienna as the Medical Faculty of the
University of Vienna. The parent body, the University of Vienna, has an impressive history, with nine
Nobel Prize winners (five in biology). The association between the Nagoya University School of Medicine and the Medical University of Vienna dates
back to the period of the parent body, the University of Vienna, when Professor Albrecht von Roretzof the University of Vienna assumed a post at Aichi
Prefectural Public Medical School, the predecessorof the Nagoya University School of Medicine, in
1876 and taught surgery. Following the signing ofan agreement between the schools of medicine of
the two universities in July 2005, we have greatly
enhanced our exchanges. This symposium also initiated links at the research level, and thus our relationship with the Medical University of Vienna has

Pictures of the presentations being made at the first international symposium14

P r o f i l e M 2 013-2014

developed from an inter-student association to aninter-research association.
We held the second international symposiumwith the University of Adelaide School of Medicine
in May 2013, in which 19 participants gave presentations on the latest research on cancer and neurological disorders. The University of Adelaide has ahistory as old as the Nagoya University School of
Medicine of 150 years and they are now building
the South Australian Health and Medical ResearchInstitute (SAHMRI) covering an area of 6,000 square
meters. When completed, the University of Adelaide will become a center of medical research inAustralia. As with the Medical University of Vienna, the Nagoya University Graduate School of Medicine was able to establish a relationship with the
University of Adelaide thanks to inter-student exchanges and was able to turn it into an inter-research exchange by holding the international symposium.

The purpose of international symposiums is toestablish collaborative relationship in studies withaffiliated schools of medicine based on an understanding of each other’s research strengths. If the
purpose is achieved, it will enable us to show theworld that the Nagoya University Graduate Schoolof Medicine has an international research base.
We have also been requested by an affiliatedschool in Germany, the Albert Ludwigs-University
Freiburg, School of Medicine to organize an international symposium. We are considering holding
such symposiums here on the Tsurumai Campus in
the future. We intend to publicize these efforts on
our website to stimulate interest in importantcross-border endeavors and, at the same time, tomotivate students toward research activities, andthus help develop outstanding human resources
who can engage in medical research. We are committed to continuing these efforts to grow as a research-intensive university.

(SAHMRI)

Special Topics

15

Enhancement of International Exchange 2)“Office of International Affairs”
KASUYA, Hideki, Associate Professor in charge of special education forforeign students, Graduate School of Medicine
Director, Office of International Affairs

As it has become so easy to gain information via
the internet, there is an increasing demand for theinternationalization of education in universities andresearch/medical fields. The position in the world
ranking of universities is also becoming more important, and so university education and medicine
must gain international acceptance, not just in Japan. As this tendency is likely to accelerate, theNagoya University School of Medicine and Graduate School of Medicine restructured the former Office of International Affairs and launched a new
system, the Office of International Affairs, in May
2013. Supervised by the Director, the Office of International Affairs comprises two teachers including a G30 foreign teacher and related administrative offices. It handles international affairs for the
School of Medicine including the School of Health
Sciences, Graduate School of Medicine, Nagoya University Hospital, and other related facilities. Most of
the universities abroad with which we have academic/student exchange agreements have university hospitals and research facilities attached to theschools of medicine. Therefore, the Office of International Affairs must achieve well-balanced internationalization with a broad scope that covers not
only the School of Medicine and Graduate School of
Medicine but also the University Hospital and research facilities. At present we are affiliated with
China-Japan Friendship Hospital and Seoul National
University Hospital and also actively exchange information with Asan Hospital and Sirindhorn Hospital mainly between the departments of nursing
and administrative departments.
We also have an agreement with Hue University
College of Medicine and Pharmacy and undertake
technical collaboration on endoscopes mainly be-

A scene of signing an agreement with Seoul National University

16

P r o f i l e M 2 013-2014

A scene of signing an agreement with National Taiwan University College of Medicine

tween the departments of gastrointestinal medicine. We expect that online meetings will play avital role in the exchange of medical informationand the collaboration on medical technology with
ASEAN countries. Additionally, since the MHLW is
now actively encouraging foreign physicians to gain
training in Japanese hospitals and to obtain a Japanese medical license, we must create the structure
for the advanced clinical training system and national examination for foreign medical practitioners.
The School of Health Sciences has an agreement on
academic/student exchange with Yonsei University, Shanghai Jiao Tong University, and National
University of Singapore, by which they have enjoyed vital academic/information/student exchanges, making visits to each other’s facilities. For the
School of Medicine and Graduate School of Medicine, we have affiliation agreements with 16
schools—mainly the leading schools in the U.S./Europe—by which 16 students, i.e. nearly 20% of all
6th grade students, underwent the 3-month clinicaltraining in schools of medicine abroad in the 2013
school year. This clinical training is an outstanding
feature of Nagoya University as it is recognized aspart of the normal clinical training; no other schoolof medicine in Japan offers clinical practice for 3
months for approximately 20% of its 6th grade students. This overseas study program includes preliminary training in English and many students are
keen to enter Nagoya University because of thisoverseas study program.
Regarding education in universities abroad, withthe accelerating globalization of society and economy and the increasing international flexibility inuniversity education, they too are actively introduc-ing programs for foreign students in the U.S./Europe, such as ERASMUS (The European Community Action Scheme for the Mobility of University
Students), and arranging cross-border education
within Europe. In Asia too, cross-border inter-university collaborative activities will flourish, leading
to more exchanges of foreign students among universities and increasing collaboration in both education and research. To be a vital part of these international interdisciplinary networks, it is importantfor Japanese universities not only to strengthen
their own international competitiveness but also tocontribute to society through education and research.
Nagoya University, under the leadership of the
President, Dr. Michinari Hamaguchi, has designed
the “Hamaguchi Plan” with the catchphrase, “FromNagoya Daigaku to Nagoya University”, and issteadily internationalizing the university. At present, there are a total of 2,536 foreigners in the entire
university—1,611 foreign students and 925 researchers from 97 countries—compared with theuniversity’s total number of undergraduates andgraduate students of 16,523, and this proportion offoreign students is increasing. In the School of Medicine and Graduate School of Medicine, a total of 112
students (78 graduate students, 12 students on
Young Leaders’ Program [YLP], 8 researchers, 2
undergraduates [School of Health Sciences], and 12
short-term annual students on the Nagoya Univer-

An affiliated school (Duke University)

sity Program for Academic Exchange [NUPACE],etc.) have been enrolled.
To provide a vital boost to the Japanese economy,
universities must foster internationalized individuals who can handle the globalization of society, andmust increase the proportion of foreign students
and students who have experience of studying
abroad. In the future, with the rapidly declining
birthrate in Japan, universities will play an increasingly important role in internationalization as a national scheme to maintain economic growth. While
many programs that need urgent coordination involving universities, such as the
Academic Consortium 21 (AC21),
the 300,000 Foreign Students
Plan, the China 5000 Students
Program, the Global 30 Projectand so forth, are being designed
one after another, the School of
Medicine and Graduate School of
Medicine have been asked todeepen the traditional approach
focusing on the U.S. and Europe,
while exploring new directions
for the Asian economy, and todevelop cooperative relationships
with leading schools in foreigncountries in the field of researchand technological development.
The Office of International Affairs intends to meet the urgent
demand from society for internationalization by globalizing the
School of Medicine and Graduate
School of Medicine.

A picture from the study-abroad program

Special Topics

17

Enhancement of International Exchange 3)“Academic Exchange with Yonsei University”
SAKAKIBARA, Hisataka
Head, School of Health Sciences
Director, Department of Integrated Health Sciences

In 2010, the Nagoya University Graduate School of
Medicine (Health Sciences) commenced a researchexchange with the health sciences/nursing departments of Yonsei University, a prestigious private
university with a long and impressive history, atthe level of the Graduate School of Medicine. Yonsei University is known for owning Severance Hospital, a modern hospital with over 2000 beds, inSeoul. We launched this research exchange with
the Department of Radiological Science, Department of Biomedical Engineering, Department of
Physical Therapy, and Department of Occupational
Therapy of the College of Health Sciences (Schoolof Health Sciences) and the Nursing School of Wonju College of Medicine (School of Medicine), all located on the Wonju campus. An agreement was
signed between Nagoya University and Yonsei University in 2008.
Results of the 3-year Exchange
The exchange was initiated at the proposal of Nagoya University, and the first Nagoya-Yonsei University Research Exchange Meeting was held on
the Daiko Campus in November 2010 hosted by Nagoya University. Including the Vice President, 19
participants comprised of teachers and graduate
students attended the meeting from Yonsei University while 200 teachers/graduate students participated from Nagoya University. After a general
meeting in the morning including greetings andkeynote reports, a research exchange was held focusing on the presentations given by the teachersand graduate students in five sectional meetings(nursing, radiology technology, medical technology,
physical therapy, and occupational therapy) per department in the afternoon. Social gatherings werethen held at each department for further exchanges. The second exchange meeting was held at Yonsei University in 2011, which was attended by 41
teachers/graduate students from Nagoya University and proved most useful. In 2011, we also began
to visit each other’s research laboratories and accepted a total of five graduate students—one student from each department—in Nagoya University
to introduce the studies conducted at the researchlaboratories. The third exchange meeting was heldin the 2012 school year, in which 32 attendees—5
teachers and 27 graduate students—participatedfrom Yonsei University and research presentations
on 53 topics were given by graduate students; wealso sent 10 graduate students from Nagoya University to Yonsei University to visit their researchlaboratories. The mutual relationship is growing
stronger as we commence the third year of our association.
Objectives of the Program and Its Features
The objectives of the program are to enhance international exchange through research presentations
at exchange meetings. The program also aims to
improve the graduate students’ motivation toward
research by broadening their international outlook,and to create opportunities for the exchange of human resources, joint research, and studying abroad

Group photograph from the 3rd Nagoya-Yonsei University Research Exchange Meeting in 2012 (held at Nagoya University)

18

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through the mutual visits by graduate students to
the research laboratories at each other’s university
in order to deepen the international exchange of
research.
This program is an initiative covering all departments related to health sciences/nursing of both
universities. By offering a joint opportunity for thegraduate students to make presentations, they gaina similar experience to an international academic
conference, where participants must give presentations and Q&A sessions in English; this has improved their motivation toward international exchange. Additionally, we hold social gatherings at
each department after the research presentations
and this helps build human ties between the two
universities. Since these gatherings are attended
not only by graduate students but also teachers,
they effectively enhance international linkages forthe entire department.

signed a memorandum on exchange with the College of Nursing of the Shanghai Jiao Tong University School of Medicine, by which we accepted two
trainees. We also accepted two students for training from the University of the Philippines in Manila
and sent four trainees from Nagoya University.
The students are active in this international exchange, and have set up their own organization toaccept foreign students, prepared and presented
slides to introduce life at Nagoya University, andare keen to plan and organize welcome parties andso forth, demonstrating the success of this international exchange. We also signed an exchange agreement with the Department of Nursing of Yong Loo
Lin School of Medicine at the National University ofSingapore in 2012, with the exchange due to start in
the 2013 school year.

International Exchange of Undergraduates forClinical Nursing Training
Prompted by the research exchange with Yonsei
University, we discussed setting up an exchange ofundergraduates for the nursing departments, as aresult of which the mutual exchange of undergraduate clinical nursing trainees was initiated in 2011.
In the same year, we sent four undergraduates toYonsei University, from which we also accepted
four trainees for training at Nagoya University Hospital and so forth. The Department of Nursing also

Conclusion
It seems likely that not only the students who weresent abroad but also those who do not visit foreigncountries are equally stimulated to develop an international outlook by meeting the foreign students
whom we accepted thanks to the positive attitudeof the foreign students, communication in English,
and so forth. We intend to extend the international
exchange program to cover both education and research. Incidentally, since the 2011 school year, thisprogram has been carried out under the auspices of
the Student Exchange Support Program by MECSST.

A scene from an exchange meeting

A scene from a tour of Nagoya University HospitalSpecial Topics

19

Center for Neurological Diseases and Cancer“Extended Operation and Restructuring of Center for Neurological Diseases and Cancer”
TAKAHASHI, Takashi
Professor, Division of Molecular Carcinogenesis
Graduate School of Medicine
Director, Center for Neurological Diseases and Cancer

The Center for Neurological Diseases and Cancerof the Nagoya University Graduate School of Medicine was founded in 2003 to focus on two fields of
medical research: neurological disorders including
neurodegenerative disease for which there is no effective treatment, and malignant tumors which are
the leading cause of death in developed countries
including Japan. The goal was to establish an international research base for foundation research anddevelopment of the latest medicines. One of thepredecessors of the Center is a bioregulatory research facility of Nagoya University established in
1983, where they were, under a system of broadranging interdisciplinary research, trying to identify a pathogenic mechanism of refractory infections
and malignant tumors and to prevent and control
the diseases. Meanwhile, at the Graduate School of
Medicine—as the Center of Excellence (COE) program, “Molecular Medicine in Neurodegenerative
Disorders and Malignant Tumors”, which waslaunched by the MECSST in the school year 1998—
they were conducting research aiming to identify
the pathogenesis of neurodegenerative diseases andmalignant tumors and had built a solid reputation
both inside and outside the university. The Center
for Neurological Diseases and Cancer was estab-lished by integrating the bioregulatory researchfacility, which had made outstanding achievements
in research on clarifying the pathogenesis of these
diseases, with research groups conducting advanced research under the COE program.
The Center has conducted sophisticated researchon molecular medicine, ranging from basic research
to elucidate the pathogenesis of neurological disorders and malignant tumors, to translational research on innovative methods for diagnosis andtreatment. Ever since the Center was founded in
2003, we have carried out combined research thatincorporates progress in medicine and biology froma broad perspective without adhering to the traditional scope of medical research within specificfields, and have produced distinguished results.
During the most recent 5 years from 2008 through2012, we published more than 350 original papers ininternational journals including Nature Genetics,
Cancer Cell, Nature Cell Biology, Journal of ClinicalOncology, Journal of Clinical Investigation, Development Cell, Neuron, Genes & Development, Proceedings of the National Academy of Sciences USA,EMBO Journal, and Journal of Cell Biology. In addition, for those studies that require a large researchbudget of over ¥10 million per year—such as Stra-

Fig. 1 Research Conducted at the Center for Neurological Diseases and Cancer

Development of innovative prophylaxis/diagnosis/treatment methods
for neurological disorders and malignant tumors

Exploration and acceleration of basic research and translational
research to identify molecular pathogenesis

Enhancement of integration
among medical/biologicalresearch and other research
fields●Engineering●Bioinformatics●Systems biology, etc.

Greater effort for technologicalinnovation and sophisticationof analytical approach●Technological innovation ofmass spectrometer andnext-generation sequencer●Improved analysis using
genetically modified animals

The base established by the advanced research conductedby the Center for Neurological Diseases and Cancer

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tegic Research Program for Brain Sciences, Projectfor Development of Innovative Research on Cancer
Therapeutics, Strategic Basic Research Programs(Core Research for Evolutional Science and Technology (CREST)), Scientific Research on Innovative
Areas, Scientific Research (S) and (A), Human Frontier Science Program (HFSP), Research on Measures for Intractable Diseases, and The 3rd-term
Comprehensive 10-year Strategy for Cancer Control—we have obtained a research budget amounting to \200–500 million annually.
When the Graduate School of Medicine was conducting the 21st Century COE program , “Integrated Molecular Medicine for Neuronal and Neoplastic
Disorders” (school years 2003-2007) followed by the
global COE program, “Integrated Functional Molecular Medicine for Neuronal and Neoplastic Disorders” (school years 2008-2012), the Center not
only played a core role but also steadily contributed
to education at the graduate school by supervising
46 students in the master course and 92 students inthe doctoral course (including 46 graduate students
in the doctoral course who had been sent from theclinical course to obtain a PhD degree) during the 5
years from 2008 through 2012.

Thus, the Center had achieved solid results by
the time the initial period expired, and in view of its
high reputation, the program was extended to 2018.
At this point, we unified the departments which
had focused on research in neurological disorders
and malignant tumors into the Department of Neuroscience (two divisions) and Department of Oncology (two divisions), and added the Department ofAdvanced Medical Science (four divisions + one division taught by a visiting professor), which conducts advanced medical research covering the other two departments, to create a structure consistingof three departments and nine divisions. This restructuring highlights the fact that the Center is a
research institute specializing in neurological disorders and malignant tumors, encompassing basic research through clinical applied research, and thecharacteristics of each research department areclearly visible inside and outside the university. In
the future, with Nagoya University already renowned as a world-leading center of medical research related to neurological disorders and malignant tumors, we will conduct even more innovative
research to solidify our international position anddevelop the next generation of medical scientists.

Fig. 2 Organizational Structure of Center for Neurological Diseases and Cancer before
and after the Reorganization
Structure of 2003-2012

Structure after Reorganizationin 2013

Organizational Structure of Center
for Neurological Diseases and Cancer
Department of Oncology
Molecular Carcinogenesis
Cancer Biology
Department of Development andRegenerative Medicine
Molecular Pathology
Neuroscience
Department of Advanced
Medical Science
Neurogenetics
Molecular Biochemistry
Molecular Mycology and Medicine
Disease Models
Post-Genomics and Diseases(Visiting professor)

Organizational Structure of Center
for Neurological Diseases and Cancer
Department of Oncology
Molecular Carcinogenesis
Cancer Biology
Department of Medical Neuroscience
Neuroscience
Neurogenetics
Department of Advanced
Medical Science
Molecular Pathology
Molecular Biochemistry
Molecular Mycology and Medicine
Disease Models
Regenerative Medicine(Visiting professor)

Special Topics

21Brain and Mind Research Center“Brain and Mind Research Center”
WAKABAYASHI, Toshihiko
Professor, Neurosurgery, Graduate School of Medicine
Chairman, Executive Committee of“Brain and Mind Research Center”

The rates of occurrence of brain diseases (dementia, Parkinson’s disease, stroke, epilepsy, brain tumor and so forth) and mind diseases (depression,schizophrenia, developmental disorders and soforth) are all high, and yet no essential prophylaxis
has been found. This leads to serious social losses
such as suicides and long-term difficulties in studying at school or working. Meanwhile, it is also extremely important to expedite research on thebrain and mind in healthy individuals to identify themechanism of growth and ageing of the brain andmind, and thus enable us to improve the quality oflife and prevent diseases. However, it is not easy to
elucidate the mechanism of the functions of thebrain, which is the most advanced and complicatedorgan in the human body. Therefore, perhaps themost significant and difficult challenge of the 21st
century is to clarify the activity of the brain andmind to overcome those diseases. Recent developments in diagnostic imaging have visualized the activities and condition of the brain and mind, suggesting that future developments in technology will
help reveal the mechanism in this field and thus
conquer the diseases.
The academic fields applied to the brain andmind are not confined to medicine but extend
broadly to education, the environment, drug discovery, engineering and others. However, there had
been no core research center covering these fields
to create a large cohort and expedite interdisciplin-ary research by organizing and integrating a consortium of researchers from diverse disciplines.
Thus, we established the Brain and Mind ResearchCenter at the Nagoya University Graduate Schoolof Medicine as of October 1, 2010. This institute unifies studies on the brain and mind as well as research of brain sciences relevant to learning andbrain–machine interfaces by utilizing the latest imaging equipment such as computed tomography(CT), magnetic resonance imaging (MRI), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET),
and single photon emission computed tomography(SPECT) as well as molecular imaging, which analyzes the brain functions at the molecular level, in
addition to diverse equipment for ‘omics’ analysis.
In the Center, we designed three research cores:
1) clarification of pathology of the brain/mind diseases, and development of next-generation innovative drug discovery, 2) clarification of the mechanism of development/ageing of the brain and mind,
and novel drug discovery based thereon, and 3) development of measures for improved QOL based on
the latest brain medicine/neuroscience. Each coreutilizes, with consideration of ethics, information
and bio-resources obtained from the three cohorts
of development, disease and ageing, by which the
integrated identification of brain/mind diseases isenhanced. Based on this foundation, we are undertaking the following strategic initiatives to clarify
the pathology and develop
next-generation drugs.

Graduate School of
Pharmaceutical Sciences
AssociatedHospitals
Development/Ageing/Disease Cohort

Academia-Hospital
Collaboration

Division ofClinical Pharmacology

Academia-Academia
Collaboration
Human Resource
Development

Collaboration with
Administrative Organs

Brain and Mind Research Center

Graduate School ofEnvironmental Studies

Brain and Mind Research Center
Development of
Education

Graduate School of Educationand Human Development

Research Institute ofEnvironmental Medicine

Eco Topia Science InstituteInternationalization
Center for Advanced Medicine and Clinical ResearchIntegrated Field-of-Expertise Type Consortium

Industry-Academia
Collaboration

AssociatedCompanies

Graduate School of Medicine, Graduate School of Environmental Studies, Graduate School of Education and Human Development,
Eco Topia Science Institute, Research Institute of Environmental Medicine, Graduate School of Pharmaceutical Sciences

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1）Core of clarification ofpathology of the diseases of the brain andmind, and developmentof next-generation innovative drugs
For the diseases of the brain
and mind including dementia,
Parkinson’s disease, stroke,
epilepsy, brain tumor, depression, schizophrenia, and developmental disorders, wewill accumulate various datasuch as brain images, molecular imaging, omics (genomes,
blood, spinal fluid, and tissues), and dead brain alongwith clinical information on alarge scale and prospectively

to build a cohort of 500-1000 subjects. Based on thedata, the intra-cerebral function networks and pathology of the brain/mind diseases will be investigated.
Additionally, by optimizing the consortium researchand cohort study, the Graduate School of Medicine,
the associated research institutes/companies, theGraduate School of Pharmaceutical Sciences and others will develop next-generation drugs based on ideas(candidate drug molecules) obtained from preclinicalresearch such as animal tests.
2）Core of clarification of the mechanism of development/ageing of the brain and mind, andnovel drug discovery based thereon
Large quantities of prospective data on the brain
structure and functions in healthy individuals ofeach generation from childhood to senescence arebeing jointly accumulated by multiple institutes including the Graduate School of Medicine, Graduate
School of Environmental Studies, Graduate Schoolof Education and Human Development, and Eco
Topia Science Institute along with information on
cognitive function, mood, sociality, life environment,
somatic functions and so forth. We will examine theprocesses of growth and ageing of the brain and theseamlessness or differences between diseases ofthe brain and mind under close cooperation withthe “core of clarification of pathology of the diseases of the brain and mind, and development of nextgeneration innovative drugs”. This will help identify
the mechanism of brain diseases associated with
developmental disorders or ageing and lead to thepromotion of development, novel drug discovery related to the prevention/treatment for ageing or interventional treatment.
3）Core of development of measures for improved
QOL based on the latest brain medicine andneuroscience
By utilizing “Neuromate”, a navigation system
known for sub-millimeter accuracy, we will develop
the next generation of microsurgery using ultrahigh-quality images obtained from intraoperative
MRI data. To operate this system, a training center
will be set up for the first time in Asia. For theparticipants in the cohort, we will use this system
to regenerate neural functions lost due to brain diseases and help the participants return to society.
Furthermore, to improve QOL, we develop technologies to visualize and assess decreased cognitive
function due to brain and mind diseases and changes in automobile driving ability associated withsleepiness properly by brain imaging.

Studies Based on Large-scale Cohorts [Projects and Objectives](Cohorts containing more than 1000 cases each. Prospective accumulation of clinical images/imaging data/biospecimens)
Genetic factors Early
environmental factors

１ ． Cohort of brain
and mind diseases
２ ． Cohort of brain andmind development/ageing

Brain
Bank

Fetus-Infant period

Clinical Information
Natural Course Analysis

Developmental disorders
Epilepsy

Schizophrenia

Approx. 1 million

Approx. 800 thousand

Toddler-Child period

Mood disorders
Dementia
Depression
Neurodegenerative diseases
Suicides30 thousand/year

Adolescent/ Young adulthood

Neural Function Imaging Analysis

Adulthood

Omics Analysis

Approx. 3 million

Elderly/Aged- Accumulation of biospecimens- Identification of molecules
related to disease
pathogenesis and pathology

MRI*, MEG*,NIRS, PET,
Neutomate*-Development ofbiomarkers/Integrated analysis(*School year 2009, 2010
supplementary installation)

Missions of Research Cores
Development ofimage-guided
microsurgery

Development ofbrain-machine interfaces
based on neural function

Analysis of pain
and neural activity

Clarification of
the mechanism ofdevelopment/ageing of
the brain and mind, andenvironmental adoption

Clarification ofpathology andestablishment ofinnovative treatment

Diagnosis/treatment
of depression anddevelopmental
disorders, andclarification of pathology

Proposal of
new learning
method basedon clarification ofneural basis

Clarification of brain and mind functions and pathology of diseases, Next-generation drug discovery, establishment of innovative
support method, development of the next generation of young researchers and specialists“Brain and Mind Research Center” Homepage

While carrying out
our own research, theBrain and Mind Research Center also provides support to facilitate individual studies ineach department. By
enhancing joint researchamong departments, we
decide and control thestandards of the dataand images used in thecohort study and consortium research, andhave created a system
to enable each researchcore to share information. In addition, we will
provide education foryoung researchers including students andgraduate students whowill lead research in thisfield in the future.

http://www.med.nagoya-u.ac.jp/noutokokoro/
Special Topics

23

History
1871 Temporary public hospital established at the School of Medicine on the site of the former Nagoya Domain conference chamber(now 3-1 Marunouchi, Naka-ku) (closed 1872). A temporary medical school was set up at Motomachi town office (closed in 1872).
1872 After the domain’s abolition, the hospital resumed operating as an alms clinic supported by contributions from donors(closed February 1873).
1873 Resumed operating as a temporary hospital (Nishihonganji-Betsuin, now 1 Monzen-cho, Naka-ku) with contributions fromresidents of the prefecture.
1873 Established Medical Training School as Alms Clinic.
1875 Renamed Aichi Prefecture Hospital.
1876 Renamed Public Medical Training School and Public Hospital.
1876 Renamed Public Medical School.
1877 Relocated to Tennozaki-cho (now 1-17 and 1-18 Sakae, Naka-ku) (opening ceremony for the hospital was held on July 1).
1878 Renamed Public Medical School.
1881 Renamed Aichi Medical School and Aichi Hospital.
1901 Renamed Aichi Prefectural Medical School.
1903 Designated as the Aichi Prefectural Medical College.
1914 Relocated to a new building constructed in Tsurumai-cho, Naka-ku (now Showa-ku).
1920 Established Aichi Medical College.
1922 Renamed Aichi Medical College Hospital.
1924 Renamed Aichi Medical College Clinic.
1931 Nationalized and renamed Nagoya Medical College and Nagoya Medical College Clinic.
1939 Nagoya Imperial University School of Medicine opened. Renamed Nagoya Imperial University School of Medicine Hospital.
1939 Established Nagoya Imperial Temporary Medical College (abolished in 1949).
1943 Established Research Institute of Aeromedical Medicine (abolished in 1946).
1944 Renamed to Nagoya Imperial University Medical College.
1944 Branch hospital of Nagoya Imperial University School of Medicine Hospital established(merged with Nagoya University Hospital in 1996).
1946 Established Research Institute of Environmental Medicine.
1947 Renamed to Nagoya University School of Medicine and Nagoya University Hospital.
1947 Renamed Nagoya University Medical College Clinic (abolished in 1950).
1949 University reorganized as Nagoya University under the new educational system. Clinic renamed Nagoya University Hospital.
1951 School of Nursing of Medicine was established at the School of Medicine (abolished in 1980).

24

P r o f i l e M 2 013-2014

1955 School of X-ray Technology School was established at the School of Medicine.
1959 School of Midwifery was established at the School of Medicine (abolished in 1981).
1959 Research Institute of Germfree Life was established at the School of Medicine (reorganized in 1983).
1961 School of Medical Technology was established at the School of Medicine.
1962 Cancer Research Institute was established at the School of Medicine (reorganized in 1983).
1965 Research Institute of Medical Mycology was established at the School of Medicine (reorganized in 1983).
1966 Graduate Course of School of X-ray Technology was established at the School of Medicine.
1969 School of X-ray Technology was renamed School of Radiological Technology at the School of Medicine (abolished in 1982).
1972 Renamed School of Medical Laboratory Technology at the School of Medicine (abolished in 1981).
1977 College of Medical Technology was established (abolished in 2001).
1983 Research Institute for Disease Mechanism and Control was established at the School of Medicine (reorganized in 2003).
1986 Institute for Laboratory of Animal Research was established at the school of Medicine (reorganized in 2004).
1996 Nagoya University Branch Hospital was unified with Main Hospital.
1996 Nagoya University Daiko Medical Center (medical clinic) was established (abolished in 2011).
1997 Established Nagoya University School of Health Sciences.
2000 Accomplishment of Prioritization of Graduate School.
2001 Master’s Course Program in Medical Science was established.
2001 Affiliation of Research Institute for Disease Mechanism and Control and Institute for Laboratory of Animal Research weretransferred to the Graduate School of Medicine from the School of Medicine.
2002 Renamed Graduate School of Medicine. Master’s Course Program in Nursing, Program in Radiological and Medical Laboratory
Sciences and Program in Physical and Occupational Therapy were established at the Graduate School of Medicine.
2003 Center for Neurological Diseases and Cancer was established at the Graduate School of Medicine.
2003 Master’s Course Program in Medical Science and Healthcare Administration was established at the Graduate School of Medicine.
2004 Doctor of Medical Science and Doctor’s Course Program in Nursing, Program in Radiological and Medical Laboratory Sciences,
Program in Physical and Occupational Therapy constituted Graduate School of Medicine.
2004 Center for Research of Laboratory Animals and Medical Research Engineering was established at the Graduate School of Medicine.
2005 Center for Medical Education was established at the School of Medicine.
2010 Center for Advanced Medicine and Clinical Research was established in Nagoya University Hospital.
2011 Brain and Mind Research Center was established.
2012 Curriculum of School of Medicine School of Health Sciences shifted to the department system.
2013 Nagoya University Clinical Simulation Center (NU-CSC) was established at the Graduate School of Medicine.

25

Past deans

TAMURA, Harukichi

April 1, 1939 – January 31, 1946

TAMURA, Harukichi

January 31, 1946 – February 9, 1946*

TOGARI, Chikataro

February 9, 1946 – February 9, 1952

KUNO, Yasu

February 9, 1952 – March 31, 1954

TOGARI, Chikataro

April 1, 1954 – March 31, 1958

YAMADA, Kazumaro

April 1, 1958 – March 31, 1960

MURAMATSU, Tsuneo

April 1, 1960 – March 31, 1962

KANDA, Zengo

April 1, 1962 – March 31, 1964

HASHIMOTO, Yoshio

April 1, 1964 – March 31, 1966

OGASAWARA, Kazuo

April 1, 1966 – October 20, 1967

KOJIMA, Koku

October 20, 1967 – March 31, 1969*

TAKAGI, Kentaro

April 1, 1969 – April 1, 1972*

ISHIZUKA, Naotaka

April 1, 1972 – March 31, 1974

TAUCHI, Hisashi

April 1, 1974 – March 31, 1976

KATOH, Nobuo

April 1, 1976 – March 31, 1978

SOBUE, Itsuro

April 1, 1978 – March 31, 1980

IIJIMA, Soichi

April 1, 1980 – July 21, 1981

KATOH, Nobuo

July 22, 1981 – July 21, 1985

SAKUMA, Sadayuki

July 22, 1985 – July 21, 1987

AOKI, Kunio

July 22, 1987 – July 21, 1989

NAGATSU, Toshiharu

July 22, 1989 – July 21, 1991

SAITOH, Hidehiko

July 22, 1991 – July 21, 1995

AWAYA, Shinobu

July 22, 1995 – March 31, 1997

NAKASHIMA, Izumi

April 1, 1997 – March 31, 1999

KATSUMATA, Yoshinao

April 1, 1999 – March 31, 2003

SUGIURA, Yasuo

April 1, 2003 – March 31, 2005

HAMAGUCHI, Michinari

April 1, 2005 – March 31, 2009

SOBUE, Gen

April 1, 2009 – March 31, 2012

TAKAHASHI, Masahide

April 1, 2012 –* by clerical reasons

26

P r o f i l e M 2 013-2014

Education/
research organization
Sharing two campuses in the Tsurumai areain Showa-ku and in the Daiko area in Higashi-ku, the Nagoya University School of
Medicine and Graduate School of Medicine
have been successfully developing as centersof medical research and medical services.
With three core elements of Education, Re-

Organizational chart

28

Executives

29

Tsurumai Campus

30

Graduate School of
Medicine

Doctoral Course (Medical Sciences)

Program in
Division of Basic Medicine
Integrated Medicine

search, and Treatment, the schools’ broadorganization, including its hospital, established a shared goal of contributing to thehealth and happiness of humankind and pur-Division of Clinical Medicine

34

Division of Clinical Pharmacology

35R esearcher Course

suing advanced domains specializing in each

(MD/PhD Course, Direct Postgraduate Course)organizational component’s area of expertise.

charge of Education and Research.

36

Affiliated Laboratories

37

Endowed Chair

38

Master’s Course Program in Medical Science42

The following pages provide an outline ofthe parts of the organization that take

32

Programin Medical Science,
Healthcare Administration Course

43

School of Medicine

44

University Medical Library45

facilities
Center for Neurological Diseases and Cancer

45

Center for Research of Laboratory Animals and	46
Medical Research Engineering
Center for Medical Education46

Nagoya University Clinical Simulation Center (NU-CSC) 46
Daiko Campus
Graduate School of
Medicine

47
Master’s / Doctoral Courses (Health Sciences)

School of Health Sciences

48
50

27

Organizational chart
Graduate Schoolof Medicine
Doctoral Course(Medical Sciences)（36 laboratories
under 3 division, 1 majors）

Center for Neurological Diseases and Cancer

Program in Integrated Medicine

Division of Basic Medicine
Division of Clinical Medicine

Department of Oncology
Department of Medical Neuroscience
Department of Advanced Medical Science

Division of Clinical Pharmacology

Researcher Course

MD/PhD Course
Direct Postgraduate
CourseMaster’s /Doctoral Courses(Health Sciences)（6 laboratories under 3 majors
for master s/doctoral courses）

Center for Research of Laboratory Animals
and Medical Research Engineering
Division for Research of Laboratory Animals
Division for Medical Research Engineering

Program in Nursing
Division for Advanced Medical Research
Program in Radiologicaland Medical Laboratory Sciences

Division for Designated Research

Program in Physicaland Occupational Therapy

Master’s Course

Program in Medical Science

Nagoya University Clinical Simulation Center（NU-CSC）(2 courses for 1 major)

Program in Medical Science, Healthcare Administration Course

Endowed Chair(18 laboratories)

School of Medicine
School of Medicine
School of Health Sciences(5 majors)

University Hospital(33 diagnosis and treatment departments, 24 central treatment facilities,
and 5 other departments)

Center for Medical Education

Nagoya University- wide Organization
Medical Library

Administration Office(Administrative offices for the School of Medicine and Graduate School of Medicine)Radioisotope Center Medical Division
Technical Center(Technical Service Office for the School of Medicine)28

P r o f i l e M 2 013-2014

Education/research organization

Executives
Graduate
Graduate
SchoolSchoolof ofMedicine
Medicine
Dean
Deanof Graduateof Graduate
SchoolSchoolof Medicineof Medicine

TAKAHASHI,
TAKAHASHI,
Masahide
Masahide(Professor)*(Professor)*

Vice-Dean
Vice-Deanfor Medical
for Medical
Education
Education

FUJIMOTO,
FUJIMOTO,
ToyoshiToyoshi(Professor)*(Professor)*

Vice-Dean
Vice-Deanfor Graduate
for Graduate
SchoolSchoolAffairs
Affairs
andandEthics
EthicsOHNO,
OHNO,
KinjiKinji(Professor)(Professor)

Vice-Dean
Vice-Deanfor Evaluation
for Evaluation

WAKABAYASHI,
WAKABAYASHI,
ToshihikoToshihiko(Professor)(Professor)

Vice-Dean
Vice-Dean
for Facilities
for Facilities
andandDrugDrug
discovery
discovery

KADOMATSU,
KADOMATSU,
Kenji
Kenji
(Professor)(Professor)

Vice-Dean
Vice-Dean
for Research
for ResearchandandFinancial
Financial
Affairs
Affairs

HASEGAWA,
HASEGAWA,
Yoshinori
Yoshinori(Professor)(Professor)

Vice-Dean
Vice-Deanfor Personnel
for Personnel
Affairs
Affairs
andandLabor
Labor

KIKKAWA,KIKKAWA,
Fumitaka
Fumitaka(Professor)(Professor)

SchoolSchoolof ofMedicine
Medicine
Dean
Deanof Schoolof Schoolof Medicineof Medicine

TAKAHASHI,
TAKAHASHI,
Masahide
Masahide(Professor)*(Professor)*

Head
Head
of Schoolof Schoolof Medicineof Medicine

TAKAHASHI,
TAKAHASHI,
Masahide
Masahide(Professor)*(Professor)*

Director
Directorof Universityof University
Hospital
Hospital

ISHIGURO,
ISHIGURO,
Naoki
Naoki
(Professor)*(Professor)*

Head
Head
of Schoolof Schoolof Healthof Health
Sciences
Sciences

SAKAKIBARA,SAKAKIBARA,
Hisataka
Hisataka(Professor)(Professor)

Other
Other
facilities
facilities
Director
Directorof Centerof Center
for Neurologicalfor Neurological
Diseases
DiseasesandandCancerCancer

TAKAHASHI,
TAKAHASHI,
TakashiTakashi(Professor)(Professor)

Director
Directorof Centerof Centerfor Research
for Researchof Laboratoryof Laboratory
Animals
Animals
andandMedical
MedicalResearchResearchEngineering
Engineering

KADOMATSU,
KADOMATSU,
Kenji
Kenji
(Professor)(Professor)

Director
Directorof Nagoyaof Nagoya
University
University
Medical
MedicalLibrary
Library

HAMAJIMA,HAMAJIMA,
Nobuyuki
Nobuyuki(Professor)(Professor)

Director
Directorof Radioisotopeof Radioisotope
CenterCenterMedical
MedicalDivision
Division

ISOBE,ISOBE,
Kenichi
Kenichi(Professor)(Professor)

Administrative
Administrative
Offices
Offices
Administrative
Administrative
Director
Director

SHIOZAKI,SHIOZAKI,
Eiji Eiji

ViceVice
Administrative
Administrative
Director
Director

TAKASHITA,TAKASHITA,
KazumaKazumaDirector,
Director,
GeneralGeneralAffairs
Affairs
Division
Division

SOTANI,SOTANI,
YuuichiYuuichiSupervisor
Supervisorof Personnelof Personnel
Affairs
Affairs
andandLabor
Labor

TSUBOI,Tadashi
TSUBOI,Tadashi

Director,
Director,
Student
Student
Affairs
Affairs
Division
Division

OWAKI,OWAKI,
Kineo
Kineo

Director,
Director,
Management
Management
Planning
Planning
Division
Division

YASUDA,YASUDA,
Hiroaki
HiroakiDirector,
Director,
Accounting
Accounting
Division
Division

DOUMAE,DOUMAE,
Hiroki
HirokiSupervisor
Supervisorof Facilities
of Facilities
Management
Management

SANO,
SANO,
TatsuakiTatsuakiDirector,
Director,
Medical
MedicalAffairs
Affairs
Division
Division

NAKAI,NAKAI,
Seiichi
Seiichi

Director,
Director,
Medical
MedicalServices
Services
SupportSupportDivision
Division

TAKEUCHI,
TAKEUCHI,
ShoujiShouji

Director,
Director,
GeneralGeneralAdministration
Administration
Division,
Division,
Daiko
Daiko
CampusCampusYAMASHITA,YAMASHITA,
KeijiKeiji* Professors* Professors
markedmarkedwith withan asterisk
an asterisk
are members
are membersof theofNagoya
the Nagoya
University
University
Education
Education
and Researchand ResearchCouncil
Council(as of(asAprilof April
1, 2013)
1, 2013)29

Tsurumai Campus

Graduate School of Medicine

Doctoral Course (Medical Sciences)/Master’s Course

School of Medicine
School of Medicine

Located next to Tsuruma Park in Showa-ku, Nagoya city,
the Doctoral Course (Medical Sciences), the Master’s Course, the School of Medicine programs
and associated facilities are concentrated on the Nagoya University Tsurumai Campus.
The School of Medicine carries out quality education and research in close collaboration withthe hospital popularly known as “Meidai Hospital” among area citizens.

Graduate School of Medicine

School of Medicine

Doctoral Course (Medical Sciences)
Master’s Course

School of Medicine

Established in 1955, the Nagoya University Graduate School

In line with the university mission, including “fosteringof Medicine has been consistently engaged in education andmedical researchers and medical professionals who re-research on academic theory and the application of medi-

spect medical ethics, and take pride in contributing to thecine while training academic researchers and professional

welfare of mankind,” the Graduate School of Medicine pro-technicians with advanced skills. In an effort to respond tovides a six-year integrated education, including a special

today’s highly advanced and diverse medical studies andcurriculum to address the future international activities of

establish a comprehensive and open research environment,

the students. Studies at the Nagoya University Graduate

the School of Medicine reorganized its educational system

School of Medicine are implemented in a broad, compre-

into four majors. This reorganization took three years, andhensive, and cross-disciplinary manner covering various

was completed in the year 2000. Today’s system was cre-areas of medicine.

ated by enhancing the Center for Neurological Diseases
and Cancer, which actively pursues cutting-edge research,
the Center for Research of Laboratory Animals and Medical Research Engineering, Master’s Course. In 2013, as thedepartments related to clinical pharmacology were established, the four programs were integrated into one program, in which the Division of Basic Medicine, Division ofClinical Medicine, and Division of Clinical Pharmacology
were established for the purpose of integrated education
and research, thus forming the current structure.
Graduate and undergraduate educational programs areprovided concurrently with research in each major program.
30

P r o f i l e M 2 013-2014

Education/research organization

Tsurumai Campus
Graduate School of
Medicine

Doctoral Course (Medical Sciences)

Program in
Integrated Medicine

Division of Basic Medicine

32

Division of Clinical Medicine

34

Division of Clinical Pharmacology

35

Researcher Course (MD/PhD Course, Direct Postgraduate Course)

36

Affiliated Laboratries

37

Endowed Chair

38

Master’s Course

Program in Medical Science
Program in Medical Science,
Healthcare Administration Course

42
43

School of Medicine

44

University
facilities

Medical Library

45

Center for Neurological Diseases and Cancer

45

Center for Research of Laboratory Animals and Medical
Research Engineering

46

Center for Medical Education46

Nagoya University Clinical Simulation Center (NU-CSC)

46

31

Doctoral Course (Medical Sciences)

Graduate School of Medicine

Program in
Integrated Medicine

Maximumenrollment

161

To enhance education for graduate students, a single
program that organically integrates basic medicine,clinical medicine, and clinical pharmacology is offered inwhich different research fields flexibly collaborate witheach other.

● Division of Basic Medicine
Field

Biological Chemistry

Department

Professor in charge

Molecular Biology

KADOMATSU, Kenji

Biomacromolecules
Molecular and Cellular Biology(FURUKAWA, Koichi)

Modecular Bacteriology

ARAKAWA, Yoshichika

Bacterial Drug ResistanceMicrobiology and
Immunology

Immunology

ISOBE, Kenichi

Cellular Immunology
Molecular Virology
Molecular Biochemistry
Molecular Mycology and Medicine

KIMURA, Hiroshi
Center for Neurological Diseases

FURUKAWA, Koichi

and Cancer
Department of Advanced Medical Science
Center for Neurological Diseases

Adavanced Medical
Science(Cooperating field)

Neurogenetics

and Cancer

OHNO, Kinji

Department of Medical Neuroscience
Center for Neurological Diseases

Disease Models

and Cancer
Department of Advanced Medical Science

Bioinformatics Analysis
Nanoengineered Molecular Diagnosis
Laboratory Animal
Science(Cooperating field)

Laboratory Animal Science

Aging Research(Partnership field)

Aging Research

AIDS Research(Partnership field)

AIDS Research

Graduate School of Engineering

HONDA, Hiroyuki
BABA, Yoshinobu

Center for Research of Laboratory Animals
and Medical Research Engineering
Division for Research of Laboratory Animals
Research Institute, National Center for
Geriatrics and Gerontology
National Hospital Organization
Nagoya Medical Center

MARUYAMA, Mitsuo
YANAGISAWA, Katsuhiko
SUGIURA, Wataru

Cell Physiology and Biophysics
Bio-Imaging
Cell Science

Cell Physiology

KUBA, Hiroshi

Cell Pharmacology(KAIBUCHI, Kozo)

Molecular Pharmacology
Neuroscience(Cooperating field)
Oncology(Cooperating field)

32

P r o f i l e M 2 013-2014

Center for Neurological Diseases

Neuroscience

and Cancer

KAIBUCHI, Kozo

Department of Medical Neuroscience

Molecular Carcinogenesis
Cancer Biology

Education/research organization

Center for Neurological Diseases
and Cancer
Department of Oncology

TAKAHASHI, Takashi

FieldDepartment

Higher Nervous
Control(Cooperating field)

Visual Neuroscience
Neuroimmunology

Regulation of Organ
Function(Cooperating field)

Neural Regulation

Molecular and Cellular
Adaptation(Cooperating field)

Genetics

Neurochemistry(Partnership field)

Anatomy and Cell Biology

Cardiovascular Research

Nearoscience and Pathobiology
Neurochemistry

Professor in charge
Research Institute ofEnvironmental Medicine

Research Institute ofEnvironmental Medicine

Research Institute ofEnvironmental Medicine

Institute for Developmental Research,
Aichi Human Service Center

KOMATSU, Yukio
SUZUMURA, Akio
YAMANAKA, Akihiro
KAMIYA, Kaichiro
MURATA, Yoshiharu
YAMANAKA, Koji
NAKAYAMA, Atsuo
NAGATA, Koichi

Molecular Cell Biology

FUJIMOTO, Toyoshi

Functional Anatomy and Neuroscience

KIYAMA, Hiroshi

Cell Biology

MIYATA, Takaki

Ultrastructual Morphology
Pathology and Biological Responses
Pathology

TOYOKUNI, Shinya

Molecular Diagnosis(TAKAHASHI, Masahide)

Tumor Pathology
Neuropathology

Development(Cooperating field)

Molecular Pathology

Center for Neurological Diseases andCancer
Department of Advanced Medical Science

SEKIDO, Yoshitaka

Cancer Genetics
Cancer Genetics(Partnership field)

Aichi Cancer Center Research Institute

Cellular Oncology

Social Life Science

Health Promotion
Medicine(Cooperating field)
Epidemiology(Partnership field)

TAKAHASHI, Masahide

SETO, Masao
INAGAKI, Masaki
KUZUSHIMA, Kiyotaka

Legal Medicine and Bioethics

ISHII, Akira

Occupational and Environmental Health

KATO, Masashi

Preventive Medicine
Public Health and Health Systems

AOYAMA, Atsuko

Healthcare Administration

HAMAJIMA, Nobuyuki

Human Nutrition
Sports Medicine

ISHIGURO, Hiroshi
Research Center of Health, Physical Fitness and Sports

Psychopathology and Psychotherapy
Epidemiology

OSHIDA, Yoshiharu
OGAWA, Toyoaki

Aichi Cancer Center Research Institute

TANAKA, Hideo
KONDO, Eisaku
Tsurumai Campus

33

Graduate School of Medicine

Doctoral Course (Medical Sciences)● Division of Clinical Medicine
Field

Department

Professor in charge

Hematology and Oncology

Internal Medicine

Cardiology

MUROHARA, Toyoaki

Gastroenterology and Hepatology

GOTO, Hidemi

Respiratory Medicine

HASEGAWA, Yoshinori

Endocrinology and Diabetes

OISO, Yutaka

Nephrology

MATSUO, Seiichi

Radiology

NAGANAWA, Shinji

Interventional & Therapeutic Radiology
High-Technology
Applicationof Medicine

Radiunon Oncology
Pathology and Laboratory Medicine

NAKAMURA, Shigeo

Diagnostic Pathology

Clinical Neurosciences

Clinical Oncology and Chemotherapy(ANDO, Yuichi)

Neurology

SOBUE, Gen

Psychiatry

OZAKI, Norio

Psychobiology
Neurosurgery

WAKABAYASHI, Toshihiko

Frontier Surgical Neuroscience
Endovascular Neurosurgery
Ophthalmology

TERASAKI, Hiroko

Protective Care for Sensory Disorders
Head and Neckand Sensory Organ
Medicine

Otorhinolaryngology

NAKASHIMA, Tsutomu

Cognitive and Speech Medicine
Maxillofacial Surgery

UEDA, Minoru

Protective Care for Masticatory Disorders

Surgery

Surgical Oncology

NAGINO, Masato

Vascular Surgery

KOMORI, Kimihiro

Gastroenterological Surgery

KODERA, Yasuhiro

Transplantation and Endocrine Surgery
Cardiac Surgery

USUI, AkihikoThoracic Surgery

YOKOI, Kouhei

Pediatric Surgery

UCHIDA, Hiroo

Urology

GOTOH, Momokazu

Orthopaedics

ISHIGURO, Naoki

Rheumatology
Musculoskeletaland Cutaneous
Medicine

Hand Surgery

HIRATA, Hitoshi

Dermatology

AKIYAMA, Masashi

Connective Tissue Disease and Autoimmunity
Plastic and Reconstructive Surgery

34

P r o f i l e M 2 013-2014

Education/research organization

KAMEI, Yuzuru

FieldBiomedical Regulation

Clinical Management
Medicine(Cooperating field)

Department

Professor in charge

Anesthesiology

NISHIWAKI, Kimitoshi

Infectious Diseases

YAGI, Tetsuya

Emergency and Critical Care Medicine

MATSUDA, Naoyuki

Operation Medicine

University Hospital
Department of Surgical Center

Cell Therapy Medicine

University Hospital
Department of Blood Transfusion Service

Anatomical Pathology

University Hospital
Department of Pathology and Laboratory Medicine

Diagnostic and Therapeutic Endoscopy

University Hospital
Department of Endoscopy

Clinical Radiology

University Hospital
Central Block of Radiology

Diagnostic Medical Image Processing

Graduate School of Information Science

Pediatrics

MATSUSHITA, Tadashi

KOJIMA, Seiji

Developmental Pediatrics
Developmental and Geriatric Psychiatry
Medicine in Growthand Aging

Community Healthcare and Geriatrics

KUZUYA, Masafumi

Obsterics and Gynecology

KIKKAWA, Fumitaka

Reproductive Oncology
Family and Community Medicine
Maternal andPerinatal Care
(Cooperating field)

Maternal and Perinatal Care

Child and Adolescent
Psychiatry(Cooperating field)

Child and Adolescent Psychiatry

Comprehensive
Ambulatory Medicine(Cooperating field)

Medical Education
Quality and Patient Safety

BAN, Nobutaro
University HospitalCenter for Maternal - Neonatal Care
University HospitalChild and Adolescent Psychiatry
Center for Medical Education
University Hospital
Department of Quality and Patient Safety

HONJO, Shuji
UEMURA, Kazumasa
NAGAO, Yoshimasa● Division of Clinical Pharmacology
Field

Department
Molecular Pharmacokinetics (Cooperating department)

Molecle Pharmacology

Molecular Pharmaco-Biology (Cooperating department)

Professor in charge
Research Institute ofEnvironmental of Medicine

Toxicogenomics

Clinical Pharmacology

Pharmaceutical
Management(Partnership field)(as of October 1, 2013)

MASUTANI, Chikahide
YOKOI, Tsuyoshi

Clinical Phamacy (Cooperating department)

University Hospital
Department of Hospital
Pharmacy

YAMADA, Kiyofumi

Clinical Oncology and Chemotherapy (Cooperating department)

University Hospital
Department of ClinicalOncology and Chemotherapy

ANDO, Yuichi

Biostatistics

Pharmaceutical R & D(Partnership field)

SAWADA, Makoto

MATSUI, Shigeyuki

Regulatory science of pharmaceuticals (Partnership department)

PMDA

HANDA, Nobuhiro

Practical Pharmaceutical R & D

Astellas Pharma Inc.

MIYATA, Keiji
SAWAMOTO, Taiji

Applied Pharmaceutical R & D

Novartis Pharmaceuticals
Japan

WATANABE, Toshihfumi
HIROSE, Toru

Mathematioal Statistics

The Institute of Statistical
Mathematics

TSUBAKI, Hiroe
EGUCHI, Shinto
Tsurumai Campus

35

Graduate School of Medicine

Researcher Course
MD/PhD Course, Direct Postgraduate Course
Direct Postgraduate Course

MD/PhD Course
This course allows research-oriented undergraduate students at
the School of Medicine to enter the Graduate School of
Medicine early to experience research very early on in theirtraining (see diagram below Ⓑ).
The students take a temporary leave of absence from the Schoolof Medicine during their fourth or fifth year to train at the Graduate School of Medicine and obtain their Doctor of Medical
Science (PhD) degree. They may return to the School of
Medicine to obtain their Doctor of Medicine (MD) degree.

This course is for research-oriented physicians who have justgraduated from the School of Medicine so that they can continue
to focus on studying without the distraction of clinical affairs (seeFig. Ⓐbelow). The Dean is responsible for supervision andparticipates in an integrated education program in collaboration
with the Department of Basic Medicine and the Department ofClinical Medicine. Financial support is available if necessary.
Those who join the Graduate Course of Medicine in the 3rd grade
are to enter this course in principle.

● Eligible persons● Eligible persons

Research-oriented undergraduate students at the Nagoya
University School of Medicine with excellent academic performance who have completed their fourth or fifth year of study. A
handful of students will be selected from each grade each year.

Doctors who have recently graduated from the school of medicine, immediately or not more than two years after completing
post-graduation training.

● Selection method● Selection method

Candidates will be questioned about their aspirations when they
file their applications for the Graduate School of Medicine toconfirm their intensions. Eligible persons will be selected basedon their qualifications for candidacy. A letter of recommendation
issued by a preceptor or the like from a basic medicine seminaror clinical training should be attached to the application form.
About ten are selected each year from those students enrolled in
the Graduate School of Medicine.

Recommended by the preceptor of basic medicine laboratories
and examined by committee.

Eligible persons for Direct Postgraduate Course are physicians immediately after
their graduation or immediately after completion of post-graduation training.
Graduates can be considered eligible for two years following their completion date.
Ordinary
enrollment

Enrollment withbachelorship

Graduation

Basic
medicinelaboratory

School of Medicine

P r o f i l e M 2 013-2014

CourseDetermining
laboratory affiliation

Post-graduate
training

B MD/PhD Course

36

A Direct Postgraduate

Education/research organization

Eligible persons for MD/PhD Courses are
students who have completed at least theirfourth year at the School of Medicine

Graduate School of Medicine

Affiliated Laboratories

Affiliated Laboratories pursuing research to produce evenmore distinguished and higher achievements throughcollaboration with unique and outstanding research institutes
in the region. Joint research with seven outside research

institutes is currently ongoing throughout the Nagoya
University Graduate School of Medicine as a whole. A total ofnine affiliated laboratories are available.

Aging Research
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

September 1, 2000

Research Institute, National Center for Geriatrics and Gerontology

MARUYAMA, Mitsuo (Visiting professor)

YANAGISAWA, Katsuhiko (Visiting professor)

AIDS Research
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

April 1, 2009

National Hospital Organization Nagoya Medical Center

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

April 1, 1999

Aichi Prefectural Colony Welfare Center for Persons with Developmental Disabilitie

NAKAYAMA, Atsuo (Visiting professor)

NAGATA, Koichi (Visiting professor)

Cancer Genetics
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

EstablishedMay 29, 2000

Aichi Cancer Center Research Institute

SETO, Masao (Visiting professor)

SEKIDO, Yoshitaka (Visiting professor)

Cellular Oncology
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

April 1, 2007

Aichi Cancer Center Research Institute

INAGAKI, Masaki (Visiting professor)

KUZUSHIMA, Kiyotaka (Visiting professor)

Epidemiology
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

October 29, 1998

Aichi Cancer Center Research Institute

TANAKA, Hideo (Visiting professor)

KONDO, Eisaku (Visiting professor)

Pharmaceutical R & D(Department of Practical Pharmaceutical R & D)
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

April 1, 2013

Astellas Pharma Inc.

MIYATA, Keiji (Visiting professor)

Program in Integrated Medicine

Collaborative organization
Teacher in charge

Established

April 1, 2013

Novartis Pharmaceuticals JapanWATANABE, Toshifumi (Visiting professor)

HIROSE,Toru (Visiting professor)

Pharmaceutical Management(Department of Mathematical Statistics)
Associated program

Program in Integrated Medicine

Collaborative organization
Teacher in charge

This seminar is provided within the Aichi Prefectural Colony Welfare
Center for Persons with Developmental Disabilities, our collaborative organization. Research on the development and control mechanisms of the nerve system is conducted with the prevention andtreatment of developmental disorders in mind. The seminar includes
three major research areas, one of which is the action mechanismand neuronal development of proteins related to cell polarity.
This program carries out hematologic malignancy research incollaboration with the Cancer Center Hospital. It is known that there
is a close relationship between cause, classification or disease
evolution and abnormalities in the genome (chromosomes) orhematologic malignancy genes. By clarifying this relationship, thisprogram strives to obtain a deeper understanding of human tumors
from the perspective of genetics and molecular biology.
Since the immune system’s response to cancer has not been fully
identified, it is critical to promote clinical research and basic
research in a balanced manner. Based on this concept, thisprogram aims to carry out activities in harmony with nonclinicalstudies using human immuno- competent cells and clinical studies
with the Cancer Center Hospital and nationwide colleges andinstitutions.
In 2007, Aichi prefecture formulated a prefectural plan to promoteanti- cancer activities. The purpose of the plan is to reduce the
carcinoma death rate (for those under age 75) by 20% including
natural attrition over the next decade. To make headway towards
this goal, this seminar promotes studies of analytical epidemiology,
preventive intervention epidemiology, and descriptive epidemiology.
Teachers are invited from a pharmaceutical company (Astellas
Pharma Inc.), which is headquartered in Japan, to teach the flow ofpharmaceutical R&D from the basics through to the final stage. The
actual work done at laboratories in pharmaceutical R&D is alsotaught.

SAWAMOTO, Taiji (Visiting professor)

Pharmaceutical R & D(Department of Applied Pharmaceutical R & D)
Associated program

Despite significant improvement in the prognosis for those with
AIDS/HIV infection due to advances in antiviral treatments, this is
still an incurable disease. This laboratory pursues research toidentify how to treat hosts (humans) and the mechanism of viraldrug-tolerance at the molecular level.

SUGIURA, Wataru (Visiting professor)

Neurochemistry
Associated programThis laboratory promotes cutting-edge research to gain a deep
understanding of the mechanisms operating at the molecular/cellularlevel to find clues that will identify the symptoms of old age andold-age specific disorders, focusing on aging-associated genes. This
laboratory also actively works to develop new ideas (seeds) for
treating Alzheimer's disease as trial efforts stretching from basic
research to clinical application.

Established

April 1, 2013

The Institute of Statistical Mathematics

TSUBAKI, Hiroe (Visiting professor)

EGUCHI, Shinto (Visiting professor)

Teachers are sent from a pharmaceutical company (Novartis Pharmaceuticals Japan), which is headquartered abroad, to explain the trends
in drug discovery from an international viewpoint, as well as the trends
in international cooperation in clinical trials. For the graduate students
in joint departments, full-time teachers of the Graduate School of
Medicine give educational and research training as vice-supervisors
under the educational guidance system of multiple teachers.
In the mathematical statistics course, mathematical statistics as
the basis of biostatistics are taught and studied. The course also
helps to produce biostatisticians who are in seriously short supply
in Japan. For the graduate students in joint departments, full-timeteachers of the Graduate School of Medicine give educational andresearch training as vice-supervisors under the educational
guidance system of multiple teachers.
(as of October 1, 2013)
Tsurumai Campus

37

Graduate School of Medicine

Endowed Chair

With the help of donations from the private sector intended topromote academic activities, this seminar was established througha Nagoya University initiative. The endowed scholarship funds
facilitate and diversify education and research according to a given

Department of Renal Replacement
Therapy

EstablishedFebruary 1, 2010

Teacher in charge

ITO, Yasuhiko (Professor in charge of Endowed Chair)

Department of Metabolic Medicine

Established

October 1, 2010

Teacher in charge

HAMADA, Yoji (Associate professor in charge of Endowed Chair)

Department of Advanced Research of
Gastroenterology

Established

Lifestyle-related diseases have become a critical social problem
throughout the globe. In particular, the metabolic syndrome thathas recently drawn attention is a condition that comes withincreased risks of arterial sclerosis in addition to the underlying
visceral adiposity. This seminar primarily studies metabolic
syndrome to identify molecular mechanisms, discover new
therapeutic targets, and develop pharmacological treatments.
Pursuing this theme can also contribute to the identification of
conditions of other lifestyle-related diseases so that innovative
treatment methods can be established for those diseases as well.
The objective of the department is to clarify the pathology of
intractable diseases in the field of gastrointestinal medicine and todevelop new treatments and test methods. We intend to identify
the pathology of ulcerative colitis, inflammatory bowel disease
including Crohn's disease, hepatic disease, malignant tumor andso forth at the molecular level and use the findings to develop
therapies and test methods. In addition, we also develop new
animal models and tools to support the research.

ISHIGURO, Kazuhiro (Associate professor in charge of Endowed Chair)

Department of HSCT Data Management
and Biostatistics
Endowed Chair:
The Japan Society for
Hematopoietic Cell Transplantation
January 1, 2009

Teacher in charge

38

There is a major need in society for comprehensive management of renal
failure through hemodialysis, peritoneal dialysis, and renal transplantation for the more than 300,000 patients in Japan with end-stage chronic
renal failure. To this end, we have been conducting research on
treatments since 2005 and have improved medical care for renal failurein the region through this department since 2010. We also make our
educational program, which has become established in the region,
available to medical professionals around Japan, and are committed tothe comprehensive management of renal failure through research,education and clinical practice incorporating peritoneal dialysis.

January 1, 2011

Teacher in charge

Establishedtheme. The seminar title represents the theme of the education andresearch conducted and if the donator desires, the name of the
donator is also used as the seminar name. The Graduate School of
Medicine has eighteen endowed chairs at this time.

SUZUKI, Ritsuro (Associate professor in charge of Endowed Chair)P r o f i l e M 2 013-2014

Education/research organization

Taking charge of the operation of the Annual Report of Nationwide
Survey for Hematopoietic Cell Transplantation in Japan, this seminarendeavors to increase the registration rate and accuracy of information.
With the authorization of the Japan Society for Hematopoietic Cell
Transplantation, the seminar discloses and uses survey results collectednationwide in collaboration with the Japanese Society for PediatricHematology, Japan Marrow Donor Program, Japanese Cord Blood
Bank Network, and other organizations. The seminar aims for further
improvement in Japanese medical transplants through various support,
including clinical testing for medical transplants, while contributing to
the improvement of hematopoietic cell transplantation throughout Asia.

Department of Molecular Cardiology
Endowed Chair:Kowa

Established

July 1, 2010

Teacher in charge

OUCHI, Noriyuki (Professor in charge of Endowed Chair)

Department of Transplant Immunology

Established

April 1, 2012

Teacher in charge

KOBAYASHI, Takaaki (Professor in charge of Endowed Chair)

Department of CKD Initiatives
Regional cooperative system

Established

November 1, 2008

Teacher in charge

YASUDA, Yoshinari (Associate professor in charge of Endowed Chair)

Department of Advanced Medicine
for Uremia

Established

April 1, 2009

Teacher in chargeLifestyle-related diseases have been steadily increasing, andestablishing treatment methods has become a major concern insociety. This seminar identifies the pathophysiology oflifestyle-related diseases (e.g. metabolic syndrome, arterialsclerosis, and ischemia disease), particularly the physiopathological significance of secreted factors (e.g. Adipo-cytokine andMyokine) at the cell or body level. Based on the unique basic
research described above, the seminar seeks to explore newpaths towards innovative treatment methods and the development of new drugs.
The department aims to "go from the basics to clinical practice" andto "establish and strengthen the foundation of medical practice" toprovide "secure, safe, and effective medical care by transplantation".
Utilizing the findings obtained by the Department of Applied Immunology, we conduct scientific research that relates directly to clinicalpractice to establish tangible basic medicine. We are actively involved
in developing human resources for the future, creating a broadresearch community covering immunology, pharmacy, engineeringscience, and agriculture, and performing joint research withhospitals, research institutes, and companies at the national level.
In Japan there are approximately 13.3 million patients who havechronic kidney disease (CKD). Since CKD is a preliminary stage ofend-stage renal failure and is a serious risk factor for cardiovascular diseases including myocardial infarction and stroke, there is apressing need to develop countermeasures against CKD. Whilecollaboration between primary care physicians and specialists isimportant in the treatment of CKD, there is no fixed system. The
department intends to establish an effective system of collaboration for CKD treatment and accumulate evidence of medical
treatments for CKD, thus helping to alleviate the disease in Japan.
By identifying uremia metabolism primarily from the perspectives of uremic toxins to establish a scientific foundation forpreventing/controlling complications. So far, the seminar has
revealed the mechanism of uremia development and involvement of protein metabolites deprived from diet (e.g. indoxyl
sulfate as uremic toxin). The seminar identifies further in-depthmolecular mechanisms, particularly intracellular communication, in addition to the molecular mechanism for complications
such as arterial sclerosis.

NIWA, Toshimitsu (Professor in charge of Endowed Chair)

Tsurumai Campus

39

Graduate School of Medicine

Endowed Chair

Department of Medical System
Management

Established

April 1, 2009

Teacher in charge

SUGIURA, Shinichi (Professor in charge of Endowed Chair)

Department of Surgical Infection

Established

October 1, 2009

Teacher in charge

SUGAWARA, Gen (Lecturer in charge of Endowed Chair)

Department of Education
for Community-Oriented Medicine

Established

October 1, 2009

Teacher in charge

YASUI, Hiroki (Associate Professor in charge of Endowed Chair)

Department of Pediatric Intensive Care
Medicine

Established

November 1, 2011

Teacher in charge

TSUKUSHI, Satoshi(Lecturer in charge of Endowed Chair)

Department of developmental disability
medicine

Established

November 1, 2011

Teacher in charge

40

MIURA Kiyokuni(Lecturer in charge of Endowed Chair)P r o f i l e M 2 013-2014

Education/research organization

As a base for encouraging innovation in frontier science andengineering, with the catchphrase, "a great doctor and a large
hospital on the palm of a hand", the department aims to build a
new system of prophylaxis and early medical care utilizing information and communications technology. We perform empiricalsocial research targeting the application of regional medical careanalysis using the Geographic Medical Information System(GMIS) and Ubiquitous Mobile Infra Structure (UMIS) by using
mobile phones and tablet devices for medical care.
As a variation of perioperative infections, wound infection is a
simple complication. However, it is a critical issue since treatment is often painful and the length of the patient’s hospital stay
may be extended. However, studies based on well-establishedevidence-based medicine for perioperative infections are scant.
This seminar has the goal of identifying best practices inwound coverage through proactive surveys of perioperative
infections, identifying risks, and random comparison surveys of
methods to close wounds.
Aiming to build a new regional medical care system for the 21st century andto nurture community-oriented healthcare providers, the department was
launched with the support of Aichi prefecture and other organizations. We are
pursuing the following three major initiatives: "Investigation of and proposals
for regional medical needs", "Enhancement of activities to raise awarenessand mutual understanding", and "Development of community-needs-oriented
healthcare providers". In recent years, we have established an education andappraisal system using simulations, and also an educational system forregional medical care by interprofessional education (IPE).
The issue of human resource development is being addressed to provide multidisciplinary treatment in the field of pediatric medicine. This department aims to nurture
specialist staff for pediatric medicine in each of the pediatrics, orthopedics, and neurosurgery divisions. We train staff who are capable of dealing with a broad range of pediatric
medicine including the pediatric intensive care unit (PICU), severe trauma, childhood
cancers and so forth. In principle, the department is for postgraduate education andworks on: 1) educating young medical care personnel and securing human resources, 2)
improving the level of special facilities in Aichi prefecture, and 3) providing information forthe public and residents in the prefecture, and understanding the current situation.
The department was established with the support of Aichi prefecture based on the"Scheme for Revitalizing Regional Medical Care in Aichi Prefecture" to train physicians
involved in medical care for handicapped children (individuals) by cooperation among
the three divisions of pediatrics, orthopedics, and pediatric psychiatry, since there is a
shortage of such physicians. The department focuses on children (individuals) withcerebral palsy or severe psychosomatic disorders, developmental disorders and so forthwhich developed in childhood. We educate students and young physicians and raiseawareness in society so that all physicians can understand medical care for handicappedchildren (individuals), thus creating an environment free of discrimination.

Department of Mental Health

Established

November 1, 2011

Teacher in charge

IRITANI, Shuji (Professor in charge of Endowed Chair)

Department of Development forCommunity-oriented Healthcare System

EstablishedMarch 1, 2012

Teacher in charge

MATSUBA, Yasumasa (Lecturer in charge of Endowed Chair)

Department of Advanced Medicine
in Cardiopulmonary Disease

Established

April 1, 2012

Teacher in charge

KONDO, Takahisa (Professor in charge of Endowed Chair)

Department of Comprehensive
Community Care Systems

Established

October 1, 2012

Teacher in charge

SUZUKI, Yusuke (Associate Professor in charge of Endowed Chair)
HIROSE, Takahisa (Assistant Professor in charge of Endowed Chair)

Department of Hip and Knee
Reconstructive Surgery

Established

April 1, 2013

Teacher in charge

HASEGAWA, Yukiharu (Professor in charge of Endowed Chair)
HAMADA, Takashi(Assistant Professor in charge of Endowed Chair)

The department was established at the request of Aichi prefecture based on the Scheme for Revitalizing Regional Medical Carein Aichi Prefecture, mainly to revitalize regional medical care andtrain human resources. The department aims to improve mental
health in consideration of biological, psychological and social
aspects based on the empirical data and needs of the patient andfamily. Our objective is to contribute to regional mental healthcare in collaboration with the medical administrative agencies of
Aichi prefecture.
The purpose of the department is to establish a community-oriented
healthcare system in collaboration with administrative agencies,
regional medical care/care providers, and the Nagoya University
Graduate School of Medicine. Nakatsugawa city in Gifu prefecture isused as a model region. The guiding principle of our activities iscollaboration among relevant professionals in the fields of health,
medical care, and care/welfare to provide consistent services toresidents, and to practice interprofessional medical education in thesystem to nurture medical personnel with high regional adaptability.
The mission of the department is to elucidate the pathology of pulmonary hypertension, an intractabledisease, and to assess and develop novel therapeutic methods. The prognosis of pulmonary hypertension
was generally considered to be unfavorable. However, as innovative new drugs were introduced one after
another, the need for early detection and treatment has been addressed, and so there is now an urgent
need to improve education and awareness of the disease. Because the treatment of pulmonary hypertension often needs to be performed in parallel with treatment of the underlying disease including circulatory
diseases and collagen disorders, collaboration with specialists in other divisions is crucial. The
department aims to identify the pathology of the disease through basic research and to build a treatment
system involving relevant facilities to establish a solid system for treating pulmonary hypertension.
The concept of the comprehensive community care system is toprovide support for medical care, care, prophylaxis, and livelihood aid by the entire community in a familiar area where one
has lived a long time. This is the future of regional care as thebasis of a highly ageing society. As the only graduate school
department in Japan that specializes in comprehensive community care, our objective is to help establish such a system which
focuses on individuality and versatility in the highly ageing society through various research, education and healthcare activities.
As the number of elderly people increases, decreased function caused bylocomotor diseases is rapidly increasing. The department focuses on studying the pathology and comprehensive treatment particularly of degenerative
diseases of lower leg joints (coxarthrosis/gonarthrosis) and proximal femur
fracture which disturb the gait. We aim to establish and provide education
on safe and accurate therapeutic methods of total hip replacement, total
knee replacement, osteotomy and so forth by multi-center research withassociated hospitals. We also conduct programs for social enlightenment
on locomotive syndrome and QOL improvement activities.
(as of May 1, 2013)
Tsurumai Campus

41

Master’s Course

Graduate School of Medicine

Program in
Medical Science

Maximumenrollment

Head of School of Health Sciences and other Schools

20This course provides basic medical knowledge and expertise to apply
this knowledge to other areas by setting a model course for students
who have graduated from undergraduate schools other than medicine,
dentistry, or veterinary medicine and desire to pursue those domains
and medical fields by blending them together. After completion of thecourse, some students go on to become engineers and educators, whileothers further enroll in a Doctor of Medical Science to become educators
or researchers (See diagram). This course provides highly advanced
professional knowledge and skills to both types of students.

Graduate School of Medicine Master’s Course,
Program in Medical Science
Graduate School of Medicine
Doctor of Medical Science
Engineers withhighly-advanced skills,
educators, and researchers

Educators and researchers
in the life sciences● Model courses to take:Course title
Genetic
medicinecourseMajor subject
Biochemistry
Pathology

Details
The purpose of this course includes conducting research assignments on the border between
molecular biology and clinical medicine (e.g. gene therapy and gene diagnosis) by learning
how to introduce new approaches and effective diagnosis method to foster professionals
engaged in these studies and promote technical development.

Immunology
Cell
medicinecourseAnatomyPhysiology
Pharmacology

Medicalengineering/
medicalinformation
courseMedicalpharmacy
courseHuman
ecologycourseHealthpromotion/
sportsmedicinecourseMedicalmanagement
course42

Medicalinformation
BionomyMedicalpharmacy

Microbiology

Immunology
Socialmedicine
Pathology
Socialmedicine
Medicalinformation

P r o f i l e M 2 013-2014

The purpose of this course includes conducting various research (e.g. correlations between
the fine structure of cells and cell function, the stimulus reception/response mechanism ofcells, intracellular signal transduction mechanisms, molecular mechanisms such as the
behaviors of chemical agents in the cells, tissue or body function/signaling mechanism interms of the cell system) to foster professionals engaged in these studies and promote technical development.
The primary purpose of this course is to train researchers and engineers working in the manufacturing industry and in developing devices used for medical treatment and medical studies,or to train those who work in the food manufacturing industry as researchers or engineers
studying the areas of bionomy, pharmacology, pathology, anatomy, bioengineering, and otherareas, or highly-skilled engineers with advanced skills in medical science and professional
knowledge who work for hospitals and are engaged in medical electronics, medical engineering, development of prosthetic appliances, or medical information system management.
This course aims to foster clinical research coordinators who can arrange clinical experiments(graduates from the university department of pharmacy) and require professional
medical/pharmacological knowledge, persons in charge of monitoring and audits toevaluate/audit clinical experiments, or clinical pharmacists to provide pharmaceutical carefocused on drug therapy.
Throughout history, humans have fought to maintain their health and lives while fighting
microbes and parasitic worms. Thanks to the discovery of highly effective antibiotics andanthelminthics, we have almost entirely conquered infections. However, numerous new problems have now surfaced; for example, persistent infectious diseases caused by resistantbacteria or atopic dermatitis rashes. Further, global environmental changes and health problems have emerged, such as endocrine-disrupting chemicals and ozone depletion. This
course is intended to train personnel who can consider the relationship between humanbeings and various environmental factors (e.g. microbes and parasitic worms) and play acentral role in the food business, health and medical industry, and public administration.
The evolution of our information-based society and advancing motorization has brought a setof ailments known as lifestyle-related diseases. Kinesitherapy has been introduced to preventor conquer such diseases, boosting demand for personnel who can accurately prescribe orcoach patients while maintaining close contact with the family doctor. Followed by an everincreasing motivation of people to spend quality and active post-retirement years, more ofthese personnel are needed by welfare institutions. The course aims to train such personnel.
This course is intended to foster professionals with a basic knowledge of medicine and medical treatment and an expert knowledge of research methods from the approach of social
medicine. In addition, the professionals must also learn the real significance of managing
medical systems and medical business administration to take leadership in various tasks
such as management of medical-related businesses, public administration in central or local
governments, and management of international cooperation projects.

Education/research organization

Program in Medical Science,
Healthcare Administration Course
Maximum

Young Leaders Program（YLP） enrollment
10

The Young Leaders’ Program (YLP) contributes to establishinga global leadership network by fostering future national leaders
in countries in Asia and Eastern Europe and deepening understanding of Japan. It also aims to establish amicable relationships between Japan and other countries and help strengthen
policy-making abilities. The program is one of the governmentfinanced foreign student programs under Japanese governnment (Ministry of Education, Culture, Sports, Science and Technology).
The program begins in October and typically extends for one
year. Students are granted a master’s degree upon completionof the program. Lectures are given entirely in English. Making
use of Japan’s advantage of having keen relationships withboth Western and Asian countries, the program offers a wide
curriculum that fits the purpose of the program fostering futurenational leaders who are capable of establishing global
personal networks. For example, special lectures, internships,

and externships provided by professionals with various backgrounds from medical administration, in addition to lectures byoverseas lecturers, are occasionally offered.
Another core feature of the YLP is the importance placed on
producing essays. This means that the program requires
students to produce a master’s thesis in English within the very
short period of one year and publish it in an international journal written in English. The curriculum is designed to cultivate
students’ ability to produce essays that can be accepted byinternational journals and give presentations on these essays.
If their master’s thesis is accepted by international journals,
it becomes valuable global property in terms of information
sharing—not only for the student but also for Nagoya University
and the student’s home country.
Many students who have completed this program in the past
are now playing an active role in ministries in charge of the
medical sector, including the Ministry of Public Health, in theirown countries or international institutions such as the WHO
and World Bank. The diagram below shows the 14 participating countries in the YLP. Candidates can apply only through the
diplomatic missions stationed in those countries (Direct applications to Nagoya University are not accepted).

● Target countries

Kazakhstan
PolandMongolia

Rumania
Uzbekistan

Kyrgyzstan

Afghanistan
Bangladesh
ThailandCambodia

MyanmarLaos
Vietnam

Malaysia

For more information on the Young Leaders’ Program (YLP), see the link below
http://www.med.nagoya-u.ac.jp/english01/YLP.html

Tsurumai Campus

43

School of Medicine

School of Medicine

The Nagoya University School of Medicine provides a consistent six-year education with the goal of developing creative
doctors and medical researchers with a well-rounded character, high ethical standards, and a scientific mind.
In response to the 1998-2000 reorganization of the Graduate
School of Medicine, all teachers in the School of Medicine

concurrently serve as teachers in the Graduate School of Medicine. This system provides a well-developed education
program according to a detailed teaching scheme. The syllabus
is specially designed for students of the School of Medicine byteachers of the Graduate School of Medicine, who are also
doctors or researchers with a high degree of professionalism.

● Program

First
year

Second
year

Third
year

Fourth
year

Fifth
year

Sixth
year

44

Fir s ts em es t e r

Elementary
medicine

Cross-departmental subjects

Seconds em es t e r(Lectures, training, and practice)

Fir s ts em es t e r(science, liberal arts, cross-departmental)

Basic subjects(science, liberal arts, cross-departmental)

Academic subjects

Basic medicine

Seconds em es t e r(lectures/training)

Fir s ts em es t e r
Seconds em es t e r

Basic seminar for medicine
Social medicine (lectures/training)

Fir s ts em es t e r

Clinical medicine(tutorials, lectures,
basic clinical technique practice)Seconds em es t e r
Fir s ts em es t e r

Clinical pathology
Clinical practiceSeconds em es t e r
Fir s ts em es t e r

Choice practiceSeconds em es t e r

Final exam

P r o f i l e M 2 013-2014

Social medicine (lectures)

Education/research organization

Medical Library

University facilities

The Medical Library and Health Science Library Room are located on the
Tsurumai Campus and the Daiko Campus, respectively, for use mainly by
undergraduates, graduate students, researchers at the School of Medicine
and Graduate School of Medicine, and medical experts at the University
Hospital.
The library provides services to support education and research in addition to
its previous role of providing library materials. The new services include
introduction of new electric documents (e.g. e-journals, e-texts, anddatabases), hosting various guidance programs and seminars, installing a PC
corner, publishing the Nagoya Journal of Medical Science, editing scientificachievements in international languages, are publishing activities online.

Serving as center that locates the history of the Nagoya University School of
Medicine in the Tokai region as we look towards the future, the Exhibition
Room of the School of Medicine on the fourth floor of the Medical Library
exhibits, stores, and publishes via website documents related to the School of
Medicine.
Independent website for Medical Library
http://www.med.nagoya-u.ac.jp/medlib/

Website for Health Science Library Room
http://health.met.nagoya-u.ac.jp/LIB/

Digital archive since the dawn of modern medicine
http://www.med.nagoya-u.ac.jp/medlib/history

Center for Neurological Diseases and Cancer

University facilities(Established: April 1, 2003)

This center facilitates the development of two particular areas
such as neurological disorders and malignancies. Systematically promoting research with a strong social need (e.g. identifying etiologic mechanisms of diseases, creating animals

models, and developing new genetic diagnostic methods andmolecular-targeted therapy), the center strives to bridge theobtained results and establish an international presence.

Department

Area

PurposeTeacher in charge

Department of Oncology

Division of
Molecular Carcinogenesis

Comprehensively identifies molecular pathogenesis of carcinoma todevelop innovative diagnosis/treatment methods for intractable cancers.

TAKAHASHI, Takashi

Clarifies carcinogenic mechanisms
due to genetic mutation andmolecular mechanisms of invasion/
metastasis of carcinoma cells.

Division ofCancer Biology

Clarifies oncogenic molecular mechanisms due to oncogenes/
antioncogenes.

SENGA, Takeshi

Department of Medical
Neuroscience

Division of
Neuroscience

Conducts research related to survival and differentiation mechanisms due to neurotrophic factors and development of kidneys.

Research is conducted on the generationand differentiation of neurons
and the molecular mechanism ofneuromuscular disorders.

Division of
Neurogenetics

Clarifies molecular mechanisms of pathological conditions in myoneural junctions
and conducts research on controlling pathological conditions, while clarifying themolecular mechanism of splicing mutation in neurological disorders.

Division of
Molecular Pathology

Research on the formation of blood vessels and neurogenesis isconducted at the whole-body level using genetically modified mice.

Division of
Molecular Biochemistry

Conducts molecular genetic/cell biological research on target molecules ofchemical therapy for cancer, focusing on the genes involved in cell division.

FURUKAWA, Koichi

Division of
Disease Models

Strives to clarify causal factors of diseases and establish treatment methods
by making disease-model animal using genetically-modified mice and the like.

TAKEI, Yoshifumi

Division of
Molecular Mycology
and Medicine

Clarifies molecular mechanisms of pathological conditions in myoneural junctions
and conducts research on controlling pathological conditions, while clarifying themolecular mechanism of splicing mutation in neurological disorders.

NAKAGAWA, Yoshiyuki

Department of Advanced
Medical Science
Clarifies pathologic conditions ofmalignancy and neurodegenerative
diseases and creates animal models
while developing treatment methods.

(Professor)(Associate Professor)

KAIBUCHI, Kozo
(Professor)

OHNO, Kinji(Professor)

TAKAHASHI, Masahide(Professor)(Professor)(Associate Professor)(Associate Professor)

Tsurumai Campus

45Center for Research of Laboratory Animals andMedical Research Engineering (Established: May 1, 2004)

University facilities

This Center consists of four divisions, including two divisions(Laboratory Animals and Medical Research Engineering) thatwere established a quarter of a century ago and integrated in
2004. The center responds to highly advanced and diverse

study needs by concentrating both research facilities and technical staff together. The Center provides a broad range of
support for education and research at the Graduate School of
Medicine and School of Medicine.

Department

PurposeDivision for
Research of Laboratory Animals

This division provides centralized control of the animal testing required by the Graduate School of Medicine and University Hospital. The
environment established in this facility allows for appropriate action in terms of animal welfare and scientifically valuable animal testing.

Division for
Medical Research Engineering

This division is designed to manage shared use of various analytical/measuring devices in the Graduate Schoolof Medicine. Concentrating the devices in one place instead of having them in each laboratory can facilitate more
effective use of this state-of-the-art equipment.
The devices are accessible to other schools at Nagoya University and the outside world.

Division for
Advanced Medical Research

Division designed to fostering successors in basic studies.

Division for
Designated Research

Division run by outside funds to achieve active and dynamic development, promotion, and reinforcement ofresearch and education at the Graduate School of Medicine.

University facilities

Center for Medical Education（Center for Postgraduate Clinical Training and Career Development, University Hospital）(Established: August 1, 2005)

The Center provides overall control of undergraduate, postgraduate, and lifelong education of all medical care personnelof the School of Medicine and the University Hospital. The
services include support for teachers of the School of Medicine
and School of Health Sciences, implementation and adminis-

tration of postgraduate clinical training for the medical anddental interns in the University Hospital, education of hospital
staff, and holding of lectures for the medical instructors in the
University Hospital and associated hospitals. The Center also
provides career support to young physicians.

Teacher in charge UEMURA, Kazumasa (Professor)

University facilities

Nagoya University Clinical Simulation Center（NU-CSC）(Established: April 1, 2013)

Launched in 2006, the Skills & IT Laboratory provides education on basic clinical skills and behavioral education and isused by nearly 2,000 people annually, a total of 20,000 people
so far. In the 2012 school year, when state-of-the-art simulators and training equipment for advanced training of surgicaldiagnosis and treatment were introduced, the institute became
Teacher in charge UEMURA, Kazumasa (Professor)

46

P r o f i l e M 2 013-2014

Education/research organization

the Nagoya University Clinical Simulation Center (NU-CSC).
The Center houses perhaps the most complete range of equipment and machinery in Japan. In the future, the Center willcontribute to lifelong training as well as postgraduate/special
training for all medical care staff engaged in regional healthcare.

Daiko Campus

Graduate School of Medicine

Master’s / Doctoral Courses (Health Sciences)

School of Medicine
School of Health Sciences

The Master’s / Doctoral Courses (Health Sciences) at the Graduate Schoolof Medicine and the School of Health Sciences at the School of Medicine
are located at the Nagoya University Daiko Campus, Higashi-ku, Nagoya.
In cooperation with the School of Medicine and the University Hospital,
the Daiko Campus comprehensively promotes education andresearch in the assistant medical field, in specialties such as nursing,
medical techniques, and rehabilitation aid.
Graduate School of Medicine

School of Medicine

Master’s / Doctoral Courses (Health Sciences)

School of Health Sciences

Amidst the ever-changing medical and health system asWith our changing social conditions, the assistant medical

medical technologies and social structures advance, thefield is also advancing and increasing in complexity day by

Daiko Campus promotes the development of medical ser-day. To cope with this, the campus pursues the develop-

vice providers who can play a central role in clinical, man-ment of outstanding medical service providers, educators,

agement, and policymaking activities. At the same time,and researchers, while keeping with a basic approach of

the campus attaches importance to fostering high-perfor-

establishing medical science technology as an academic

mance researchers/educators that will promote academic

domain.

pursuits in the health sciences through interdisciplinary
and pioneering research.

Daiko Campus
Graduate School of Medicine Master’s / Doctoral Courses (Health Sciences)
Program in Nursing

48

Program in Radiological and Medical Laboratory Sciences

48

Program in Physical and Occupational Therapy

49

School of Medicine School of Health Sciences50

47

Graduate School of Medicine

Master’s / Doctoral Courses (Health Sciences)
Respecting the dignity of humankind, this course cultivates
healthcare professionals with outstanding specialist capabilities. Further, the course strives to foster creative and inquisitive
researchers/educators to formulate evidence-based learning in
the medical technology sciences.

Program in Nursing
Maximum enrollment［ First semester ］18［ Second semester ］6

Master’s Course

Fundamental and Clinical Nursing

Nursing for Developmental Health

Doctoral Course

Professor in charge

Fundamental and Clinical Nursing

YAMAUCHI, Toyoaki
OTA, Katsumasa
IKEMATSU, Yuko
ANDO, Shoko
FUJIMOTO, Etsuko
HONDA, Ikumi

Nursing for Developmental Health

SAKAKIBARA, Hisataka
KAJITA, Etsuko
MAEKAWA, Atsuko
HIRAI, Makoto
ASANO, Midori
NARAMA, Miho
TAMAKOSHI, Koji
(as of October 1, 2013)This program is primarily concerned with cultivating researchers and educators by approaching and understanding information on the human body from both a macro and micro perspective, in addition to developing professionals with advanced
specialist capabilities such as medical physicians.

Program in Radiological andMedical Laboratory Sciences
Maximum enrollment［ First semester ］20［ Second semester ］7

Master’s Course

Radiological Sciences

Pathophysiological Laboratory Sciences

Doctoral Course

Professor in charge

Radiological Sciences

KODERA, Yoshie
SHIMAMOTO, Kazuhiro
ISHIGURE, Nobuhito
IKEDA, Mitsuru
KATO, Katsuhiko
ISODA, Haruo
YAMAMOTO, Seiichi
IMAI, Kuniharu

Pathophysiological Laboratory Sciences

MURATE, Takashi
KOJIMA, Tetsuhito
WAKUSAWA, Shinya
KAWABE, Tsutomu
KONDO, Takaaki
NAGASAKA, Tetsuro
NAGATA, Kozo
ISHIKAWA, Tetsuya(as of October 1, 2013)48

P r o f i l e M 2 013-2014

Education/research organization

The program is designed to develop researchers and professionals with highly advanced skills who can sufficiently
respond to ever-changing medical situations. Meanwhile, theprogram aims to establish a diverse and vital education system(e.g. collaboration between various clinical practices and areasof study) to define new fields of inquiry.

Program in Physical andOccupational Therapy
Maximum enrollment［ First semester ］10

Master’s Course

Physical Therapy

Occupational Therapy［ Second semester ］4Doctoral Course

Professor in charge

Physical Therapy

KAWAMURA, MorioSUZUKI, Shigeyuki
YAMADA, Sumio
TORIHASHI, Shigeko
UCHIYAMA, Yasushi

Occupational Therapy

SUZUKI, Kunihumi
HOSHIYAMA, Minoru
KARASHIMA, Chieko
SAWADA, Yuji
(as of October 1, 2013)

Daiko Campus

49

School of Medicine

School of Health Sciences

The purpose of the School includes the development of medical service providers, educators, and researchers with a broad
range of basic knowledge and sophisticated expertise, anoutstanding ability to solve problems, as well as a rich sense ofhumanity. This purpose is pursued by establishing medical

technology science as a field of study, while educating in andstudying science, technology, and implementation techniques.
The course consists of 5 majors, providing a four-year integrated education from basic to professional disciplines.

● Organization

Department of Nursing
Maximum enrollment

80

Department of Radiological Technology
Maximum enrollment

40

Department of Medical Technology
Maximum enrollment

40

Department of Physical Therapy
Maximum enrollment

20

Department of Occupational Therapy
Maximum enrollment

50

20

P r o f i l e M 2 013-2014

Education/research organization

The purpose of the Department of Nursing is to study humankind, the environment, health and nursing. The Department
trains nurses, public health nurses, maternity nurses, andeducators/researchers who are skilled in conducting scientificnursing.

The Department of Radiological Technology trains radiological
technicians who can meet the current situation of diagnostic
imaging and radiation therapy which is rapidly progressing, as
well as educators and researchers in this specific field.

The purpose of the Department of Medical Technology is todevelop clinical laboratory technicians with problem-solving
skills based on knowledge and techniques related to the latest
testing, and to train educators and researchers in this specificfield.

The purpose of the Department of Physical Therapy is to acquire a broad
range of knowledge and culture related to human dignity, prophylaxis
and recovery of impairments, team medicine, establishment of the basisof physical therapy and so forth. We also aim to train physical therapists
who can contribute to and demonstrate leadership in the whole range of
medical care, health and welfare of the next generation.
The purpose of the Department of Occupational Therapy is to train humanresources who have mature humanity based on bioethics that allows them to understand and support the patients who undergo occupational therapy, who are
equipped with the academic background required to conduct research and development scientifically, and who can work actively in an international setting with an
inquiring mind. We also conduct education and research related to the above.

Data
Administration office organizational chart

52

Number of personnel

53

Maximum enrollment and current number of students

54

Number of Graduate School of Medicine graduates

56

Number of School of Medicine graduates

57

Number of students granted doctorates (MDs)57

Number of foreign students/researchers and the like58

Number of students sent out/accepted under international
59
exchange agreements
Number of exchange students sent from the Graduate
60
School of Medicine/School of Medicine by country
Medical Library61

Use survey of Skills & IT Laboratory

61

Number of necrotomies

61

Data on government-industrial-academic collaboration :62
intellectual property, collaborative/funded research
Summary of Grant-in-Aid for Scientific Research

63News release64

Extension courses at Tsurumai Campus

6851

Administration office organizational chart
General Affairs Division

Director,
General Affairs DivisionVice-Director, General Affairs Division

General Affairs Section
School Administration Section
Hospital Administration Section

Vice-Director, General Affairs Division
General Affairs and Planning Director
Personnel Affairs and Labor Group,
General Affairs Division

Supervisor of
Personnel Affairs and Labor

Vice-Director, General Affairs Division
Risk Management Director

Clinical Training Section
Planning Section

Risk Management Section
Personnel Affairs and Labor Section I

Vice-Drector, Parsonnel Affairs and Labor Group, General Affairs Division
Safety and Sanitation Management Director

Personnel Affairs and Labor Section II
Personnel Affairs and Labor Section III
Safety and Health Control Section
Specialist
Student Affairs Section

Student Affairs Division

Graduate School Section

Director,
Student Affairs DivisionInternational Exchange
and Foreign Students Section
Specialist
Specialist

Management Planning Division

Administrative
Director

Vice
Administrative Director

Director,
Management Planning
DivisionManagement and Planning Section

Vice-Director, Management Planning Division

Management Analysis Section
Research Cooperation Section

Vice-Director, Management Planning Division
Research Support Director
Accounting Division

Director,
Accounting Division

Specialist

Clinical Trial Promotion Section
Advanced Medicine Support Section
Accounting Section

Vice-Director, Accounting Division

Supplies Section
Medical Equipment Section
Specialist
Facilities Management Section
Specialist

Facilities Management Group, Accounting Division

Building and Repairs Section

Supervisor of
Facilities Management

Electricity Section
Machinery Section
Medical Affairs Section
Specialist

Medical Affairs Division

Director, Medical
Affairs Division

Medical Care Payment Section

Vice-Director, Medical Affairs Division

Medical Affairs and Accounting Section
Cashier's Section
Medical Record Control Section

Medical Support Section

Medical Services Support Division

Specialist

Director, Medical
Services Support Division

Patient Service Section
Community Liaison Section
Administration Section

General Administration Division, Daiko Campus

Director, General
Administration Division, Daiko Campus

Student Academic Affairs Section
Treasury Section

Nagoya University Medical Library

Information Management Section

Librarian

Information Service Section
Health Science Information Section(Daiko Campus)

52

P r o f i l e M 2 013-2014

Number of personnel
Title

Faculty member

Graduate School of Medicine(Daiko Campus)

Professor

51 （9）

37 （1）

Associate Professor

54 （13）18 （1）

Lecturer

16 （17）

3

Assistant Professor

36 （58）24

Research Associate

10Researcher

0 （5）

0

Research Assistant01

Subtotal
General office staff

Graduate School of Medicine(Tsurumai Campus)

158（102）83 （2）

Administrative Staff

157

Total

398（104）

Note: Numbers in parentheses indicate additional number of specially appointed teachers.

(as of May 1, 2013)

Data

53

Maximum enrollment and current number of students
Graduate School of Medicine［Doctoral Course (Medical Sciences)］
Program in Integrated Molecular
Medicine

Male

FemaleTotal

Second year

52

55

15

70

Third year

52

44

19

63

52

35

21

56

156

134

55

189

Second year

43

33

10

43

Third year

43

22

10

32

Forth year

Subtotal

Program in Cell Information
Medicine

43

32

13

45

129

87

33

120

Second year

39

40

11

51

Third year

39

32

8

40

Forth year

Subtotal

Program in Function Construction
Medicine

Current number of students

Maximumenrollment

39

37

6

43

117

109

25

134

Second year

27

10

9

19

Third year

27

12

11

23

Forth year

27

15

27

42

81

37

47

84

161

161

50

211

Subtotal

161

161

50

211

Total

644

528

210

738

Reserch student at the graduate school

̶

12

7

Forth year

Subtotal

Program in Health and Community
Medicine
Subtotal

Program in Integrated Medicine＊First year19
(as of April 1, 2013)*Including the enrollment for autumn 2012.

［Direct Postgraduate Course］
First year
Second year

Current number of students

Maximumenrollment

Male

Female

Total

̶
̶

1
1

0
0

1
1

1
3

0
0

1
3

̶
̶

Third year

Total

(as of April 1, 2013)［MD/PhD Course ］
First year

Total

Current number of students

Maximumenrollment

Male

Female

Total

̶
̶

0
0

1
1

1
1
(as of April 1, 2013)［Master’s Course (Health Sciences)］
First year

Program in Nursing

Second year
First year

Program in Radiological and Medical
Laboratory Sciences

Second year

Program in Physical and Occupational Therapy

Second year

Total
54

P r o f i l e M 2 013-2014

First year

Current number of students

Maximumenrollment

Male

Female

Total

18
18

4
5

14
14

18
19

20
20

18
18

10
21

28
39

10
10

11
12

5
6

16
18

96

68

70

138
(as of April 1, 2013)

［Doctoral Course (Health Sciences)］

Program in Nursing

Current number of students

Maximumenrollment

Male

FemaleTotal

First year

6

0

6

6

Second year

6

0

6

6

Third year

6

4

19

23

First year

Program in Radiological and Medical
Laboratory Sciences

7

7

4

11

Second year

7

4

1

5

Third year

7

3

5

8

Program in Physical and Occupational
TherapyFirst year

4

3

2

5

Second year

4

5

0

5

Third year

Total

4

7

2

9

51

33

45

78
(as of April 1, 2013)［Master’s Course］
Maximumenrollment

Current number of students
Male

FemaleTotal

First year

20

6

10

16

Second year

20

16

7

23

Program in Medical Science, Healthcare
First year
(governmentAdministration Course
sponsored)〈Young Leaders’ Program( YLP)〉

10

7

4

11

Total

50

29

21

Program in Medical Science50(as of April 1, 2013)

School of Medicine［School of Medicine ］

Current number of students

Maximumenrollment

Male

FemaleTotal

First year

107

90

21

111

Second year

107

83

27

110

Third year

112

87

30

117

Forth year

112

91

17

108

Fifth year

108

86

22

108

Sixth year

100

81

24

105

Total

646

518

141

659

Reserch student and others

̶

48

15

63
(as of April 1, 2013)［School of Health Sciences］
Current number of students

Maximumenrollment

Male

FemaleTotal

First year

200

58

151

209

Second year

206

61

158

219

Third year

226

65

161

226

Forth year

226

67

173

240

Total

858

251

643

894

Reserch student and others

̶

1

0

1
(as of April 1, 2013)
Data

55

Number of Graduate School of Medicine graduates［Doctoral Course (Medical Sciences)］

Note: Figure exclude those who finished the PhD program without completinga dissertation, and include those who completed the program more quickly.

Major

Number of students who completed the program [2012 academic year]

Program in Integrated Molecular Medicine

14

Program in Cell Information Medicine

27

Program in Function Construction Medicine

12

Program in Health and Community Medicine

15
68

Total

(as of March 31, 2013)［Master’s Course (Health Sciences)］ Note: Include those who completed the program more quickly.
Major

Number of students who completed the program [2012 academic year]

Program in Nursing

17

Program in Radiological and Medical Laboratory Sciences

22

Program in Physical and Occupational Therapy

16
55

Total

［Doctoral Course (Health Sciences)］(as of March 31, 2013)

Note: Figure exclude those who finished the PhD program without completinga dissertation, and include those who completed the program more quickly.

Major

Number of students who completed the program [2012 academic year]

Program in Nursing

2

Program in Radiological and Medical Laboratory Sciences

3

Program in Physical and Occupational Therapy

4
9

Total

(as of March 31, 2013)［Master’s Course］● Number of students who completed the program
Major

Number of students who completed the program [2012 academic year]

Program in Medical Science18（8）(as of March 31, 2013)

Note: Numbers in parentheses indicate additional number of YLP graduates● Careers of those who completed the course
Employed

Proceed tohigher education
9

Private sector

Medical institutions

4

4

0

Note: Numbers in parentheses indicate additional number of YLP graduates

56

P r o f i l e M 2 013-2014

Other
1（8）
(as of March 31, 2013)

Number of School of Medicine graduates［Number of successful undergraduates］
SchoolPeriodNumber of graduates

Aichi Medical School

October 1881 – June 1903

1,082

Aichi Prefectural Medical College

July 1903 – June 1920

1,967

Aichi Medical College

October 1920 – April 1931

427

Nagoya Medical College

May 1931 – March 1939

695

Nagoya Imperial University School of Medicine

April 1939 – September 1947

749

April 1944 – March 1950

744

October 1947 – March 1954

688

Nagoya Imperial University Medical College＊

Nagoya University School of Medicine(Under Old Educational System)
Nagoya University School of Medicine

8,060

May 1949 – March 2013

School of Medicine
School of Health Sciences（5,670）（2,390）March 2002 – March 2013

14,412

Total* Renamed Nagoya University Medical College Clinic in October 1947

［Number of School of Medicine graduates in 2012 academic year ］
Number of graduates
Nagoya University Schoolof Medicine

School of Medicine

109

School of Health Sciences

228
337

Total

(as of March 31, 2013)

Number of students granted doctorates (MDs)［ Number of persons granted degrees］
StatusNumber of degrees granted2012 academic year

Total

Graduates of Doctor’s Course

129

2,888

Doctor’s Approved by Thesis

20

3,382

Total

149

6,270
(as of March 31, 2013)*Total consists of the number of degrees granted on and after April 1, 1960.

［Number of degrees granted under old school system］
PeriodFrom:

January 23, 1926

To:

March 31, 1960

Number of degrees granted
3,709

Data

57

Number of foreign students/researchers and the like
［Number of foreign students accepted ］
Government-financed foreign students Privately-financed foreign students

Status

Total

Male

FemaleMale

FemaleUndergraduate Students

0

0

2

4

6

Research Students

0

0

0

0

0

Special Undergraduate Students

0

0

0

0

0

Graduate Students in Doctor’s Course

19

14

30

32

95

Research Students in Doctor’s Course

2

0

2

4

8

Special Graduate Students in Doctor’s Course

0

0

0

0

0

Special Research Students

0

0

0

1

1

Japanese Studies Students＊

0

0

0

0

0

21

14

34

41

110

Total

83

Visiting Research Fellow, etc.

Studies Students belong to the Education Center for International Students, Nagoya University. Those students* Japanese
become research students pursuing doctoral degrees at the Graduate School of Medicine after completing the program(as of May 1, 2013)(April through September).

［Number of foreign students by country/visiting research fellows, etc.］
Country
China
Korea
TaiwanIndia
Indonesia
Cambodia
Thailand
Nepal
Pakistan
Bangladesh
Vietnam
Malaysia
MyanmarMongolia
Laos
AfghanistanIsrael
Iraq
Iran
Egypt
Ethiopia
Palau
U.S.A.
CanadaBrazilPeru
IrelandUK
Italy
Uzbekistan
Austria
GreeceKirghiz
PolandSpain
Germany
FranceBulgaria
Belgium
Romania
Russia58

Total

P r o f i l e M 2 013-2014

Foreign students ( as of May 1, 2013 )
65
2
2
1
1
1
1
1
1
16
0
2
1
1
1
2
0
0
0
3
1
0
0
0
0
1
0
0
1
1
0
1
1
0
0
2
0
0
0
1
0
110

Visiting research fellows, etc. [2012 academic year]
4
36
2
4
0
0
7
0
0
1
2
0
0
0
0
0
1
3
1
1
0
2
2
1
1
0
1
2
1
0
1
0
0
1
1
2
2
1
1
0
2
83

Number of students sent out/accepted underNumber of students sent out/accepted underinternational exchange agreementsinternational exchange agreements
Number of
students sent

Number of
students accepted

July 3, 1989

0
0

0
0

November 28, 1995

0
0

0
0

November 29, 1995

2
2

3
3

March 26, 1997

0
0

0
0

December 20, 2002

2
2

0
0

Johns Hopkins University, School of
Medicine

January 1, 2003

2
2

0
0

The University of Texas, School of
Medicine

August 8, 2007

0
0

0
0

Medical University of Gdanisk

July 31, 1995

2
2

0
0

Germany(1 institutions)

Albert-Ludwigs-University Freiburg,
School of Medicine

April 5, 2000

2
2

0
0

UK
(1 institutions)

Warwick University, Medical School

July 22, 2005

1
1

0
0

Austria(1 institutions)

The Medical University of Vienna

July 12, 2005

2
2

2
2

Mongolia(1 institutions)

Health Sciences University of Mongolia

August 26, 2004

0
0

0
0

Shanghai Jiao Tong University

December 1, 2009

2
2

2
2

Peking University Health Science Center

November 10, 2010

0
0

2
2

Country

SchoolThe University of North Carolina,
School of Medicine at Chapel Hill
Harvard University Medical School
Tulane University, School of Medicine

USA( 7 institutions)

University of Pennsylvania, School of
Medicine
Duke University, School of Medicine

Main
SisterUniversity Poland(1 institutions)China(2 institutions)

Agreement
established on

Taiwan(1 institutions)

National Taiwan University College ofMedicine

June 17, 2011

Korea
(1 institutions)

Yonsei University Wonju College ofMedicine

0022March 29, 2012

Vietnam(1 institutions)

12
12

27
27

Hue University of Medicine and Pharmacy

October 29, 2012

0
0
9
9
0
0
6
6
16
16
10
10
0
0

0
0
0
0
0
0
0
0
0
0
0
0
0
0

68
68

38
38

North America
South America
EuropeOut ofMain
SisterAsia
University
Oceania
Africa

Total
Total

(2012 academic year)(2012 academic
year)
Data

59

Number of exchange students sent fromthe Graduate School of Medicine/School of Medicine by country

CountryState

1

Afghanistan

USA

Kentucky1

North Carolina

3

Pennsylvania

1

Massachusetts

1Maryland

4

Louisiana

2

UK

4

Australia

10Austria2

Canada3

Thailand5

Germany

4Bangladesh

1

Poland

2

Malta

1

Korea

16

China

7

Total
Note: Figures include students sent abroad.

60

Number of students studying abroadP r o f i l e M 2 013-2014

68(2012 academic year)

Medical Library (including Health Science Library Room)［Number of journal types］［Number of books collected］
Number of books collected

Medical Library Health Science Library

Number of types

Medical Library Health Science Library

Total

Total

Japanese Books

67,08338,650105,733

Japanese Journals

1,864

853

2,717

Foreign Books

87,894

7,049

94,943Foreign Journals

2,399

174

2,573

Total

154,977

45,699200,676

Total

4,263

1,027

5,290

(as of April 1, 2013)(as of April 1, 2013)［ Open-access journal ］(website released in February and August )Nagoya Journal of Medical Science
http://www.med.nagoya-u.ac.jp/medlib/nagoya̲j̲med̲sci/

Use survey of Skills & IT Laboratory［Status of use by room］［Status of use by department］

Room

Number of uses
[2012 academic year]

Department

Number of uses
[2012 academic year]

Skills lab

494

School of Medicine

906

Medical examination andtreatment simulation room

859

School of Health Sciences

82

Graduate School of Medicine

118

Microscope lab

198

Center for Medical Education

19

Diagnostic imaging lab

92

Hospital

473

Ultrasonography lab

15

Other

60

1,658

Total

1,658

Total

Number of necrotomies
Academic year

Bodies donated for systemic anatomy( number of donor bodies )Bodies for pathologic autopsy

2005

39

36

2006

49

42

2007

52

33

2008

45

38

2009

64

32

2010

49

29

2011

42

24

2012

57

39

Data

61

sity by securing ownership as a university organization as a whole, rather
than by individual researchers. To be in line with cross-departmental
policy, the Graduate School of Medicine disseminates its intellectual

tionally, there is close collaboration with companies, which is shiftingfrom researchers' individual activities to the organizational activities of
the university and expedited comprehensively.

● Number of patents (filed)
After university incorporation in 2004, Nagoya University has strived toachieve further effective use of intellectual property created at the university by securing ownership as a university organization as
24a whole, rather
than by individual researchers. To be in line with cross-departmental
6
policy, the GraduateTotal
School of Medicine disseminates
30 its intellectual

properties as "seeds" to contribute to wider society, while effectively
using them with the comprehensive strength of its organization. Addicollaboration with
18 tionally, there is close
6
4 companies, which52is shifting
activities of
6 from researchers' 0individual activities to
1 the organizational 13
expedited comprehensively.
24 the university and 6
5
65

Data on government-industrial-academic collaboration:
intellectual property, collaborative/funded research［Patents］(as of April 1, 2013)［Patents］●
List of patents(filed,Graduate School of Medicine/University Hospital, domestic sole application)● Numberof patents(filed)Title of invention
Cytodiagnostic marker easy-to-perceive with naked eye

Date of registration
March 11, 1997

Patent number
2615427

Midkine receptor, method for suppressing survival of 24
midkine-dependent cell and method forstimulating survival of midkine-dependent cell
6
Positive pressure chamberfor
extremities
Total
30

July18
8, 2005
6
January
249, 2009

6369473104243647
6

Inventor ( s )YOSHIDA, Yasuhiko
MURAMATSU,4Takashi／MURAMATSU,52
Hisako1
13
HIRATA, Hitoshi5 et al.
65

Material for ameliorating skin tissue andmethod for producing the same

January 23, 2009

4247333EBISAWA, Katsumi／KATOH, Ryuji／(as of April 1, 2013)
KAGAMI, Hideaki／UEDA, Minoru
HIRATA, Hitoshi／TATEBE, Masahiro／
External wound ﬁxing device
May 15, 2009
4304321
SHINOHARA, Takaaki● List of patents (filed, Graduate School of Medicine/University Hospital, domestic sole application)
Biomarker for the estimation of acute renal disorder and
KADOMATSU, Kenji／YUZAWA, Yukio／
December 18, 2009
4423375
prognosis of the disorder, and use of the biomarker
HAYASHI, Hiroki／MATSUO, Seiichi et al.
Strong inhibition of vascular endothelial growth factor
TAKEI, Yoshifumi／KADOMATSU, Kenji／
March 26, 2010
4480125
onset using SiRNAMURAMATSU, Takashi
Optical interference tomograph
April 30, 2010
4501007
ITOH, Yasuki
Method for handling preserved cells
June 11, 2010
4528584
KAGAMI, Hideaki／UEDA, Minoru et al.
Activation inhibitor of mechanoreception(stretch activated) channel

January 7, 20114654432

NARUSE, Keiji／SOKABE, Masahiro

Detector for magnetic signal from cellular structure

January 21, 2011

4665105

NAKAYAMA, Shinsuke／UCHIYAMA, Tsuyoshi et al.

Method of detecting IgA nephropathy-related antibody

March 18, 2011

4701391TORII, Keizo／OHTA, Michio／OKAMOTO, Akira

Incubation schedule management device and incubation schedulemanagement program
Composition for inhibiting cancer metastasis

July 29, 20114787964

KATOH, Ryuji／KAGAMI, Hideaki／UEDA, Minoru
EBISAWA, Katsumi
TAKAHASHI, Takashi／YANAGISAWA, Kiyoshi

August 12, 2011

4797159

Method for regenerating dentin from human pulp cells
Prophylactic or therapeutic pharmaceutical composition for nerve
disorders

December 16, 2011

4884678

February 24, 2012

4929446

Cell preparation for erectile dysfunction or urinary incontinence
containing adipose tissue-derived mesenchymal stem cells

March 23, 2012

4953335

Therapeutic agent for polyglutamine disease

March 30, 2012

4956737

Histogenetic composite material and its production method

April 27, 2012

4977854

Tissue-engineered bone composition

May 11, 2012

4982841

Dermal tissue improving material and use thereof

May 11, 2012

4982865

Grafting material and agent for improving bone quality

June 1, 2012

5002816

Cell preparation for treating prostate cancer containing adipose
tissue-derived mesenchymal stem cells
Application of actin-binding protein to diseases associated withcell motility
Method for establishing cell line of human malignant ovarian germ
cell tumor, human malignant ovarian germ tumor, and use thereof
Application of actin-binding protein to diseases associated withcell motility
Pharmaceutical composition for treatment or prevention of livercancerJuly 13, 2012

5035737

August 3, 2012

5051600

UEDA, Minoru／MIZUNO, Hirokazu／KAGAMI, Hideaki／
OKADA, Kunihiko／USAMI, Kazutada
UEDA, Minoru／YAMADA, Yoichi／ITOH, Kenji／
YOSHIMI, Ryoko
EBISAWA, Katsumi／UEDA, Minoru／
KAGAMI, Hideaki／OKADA, Kunihiko／
KATOH, Ryuji／Mazlyzam Abdule Latif
UEDA, Minoru／YAMADA, Yoichi／YAJIMA, Akihiro／KOHGO, Tomoyuki
YAMAMOTO, Tokunori／KOIDE, Naoshi／
TAKEI, Yoshifumi／GOTOH, Momokazu
TAKAHASHI, Masahide／ENOMOTO, Atsushi／
MUROHARA, Toyoaki

October 5, 2012

5098013KIKKAWA, Fumitaka／SHIBATA, Kiyosumi

October 5, 2012

5098027

TAKAHASHI, Masahide／ENOMOTO, Atsushi／
MUROHARA, Toyoaki

October 12, 2012

5103608

NAKAO, Akimasa／SAKAKIMA, Katsutoshi

Method for control of electroporation apparatus

January 18, 2013

5176104

Pharmaceutical composition for treatment or prevention of intraabdominal tumor lesions
Oligonucleotide set for detecting viruses, analyzing method anddetection kit for EBV, CMV, and HHV-6

February 1, 2013

5187676

March 1, 2013

5205609

TAKEI, Yoshifumi／FUJISHIMA, Tatsuya／
MURAMATSU, Takashi／KADOMATSU, Kenji
NAWA, Akihiro／KAMAKURA, Maki／
KIKKAWA, Fumitaka／NISHIYAMA, Yukihiro
KIMURA, Hiroshi／NISHIYAMA, Yukihiro／
WADA, Kaoru／KUBOTA, Naomi

KAGAMI, Hideaki／UEDA, Minoru et al.
KADOMATSU, Kenji／ZHANG Hao-Qian／
MURAMATSU, Takashi／UCHIMURA, Kenji
YAMAMOTO, Tokunori／GOTOH, Momokazu／
KOIDE, Naoshi／TAKEI, Yoshifumi／MATSUKAWA,
Yoshihisa／FUNAHASHI, Yasuhito
SOBUE, Gen／ADACHI, Hiroaki／WAZA, Masahiro(as of April 1, 2013)62

P r o f i l e M 2 013-2014

achieve further effective use of intellectual property created at the university by securing ownership as a university organization as a whole, rather
than by individual researchers. To be in line with cross-departmental
policy, the Graduate School of Medicine disseminates its intellectualusing them with the comprehensive strength of its organization. Additionally, there is close collaboration with companies, which is shiftingfrom researchers' individual activities to the organizational activities of
the university and expedited comprehensively.

［Patents］● Number of patents (filed)
Domestic

Organization

Sole application
24

Graduate School of Medicine
University Hospital

Total

Overseas

Joint application Sole application
18
6

Total

Joint application
4

6

6

0

1

30

24

6

5

52
13
65
(as of April 1, 2013)［Collaborative research ］● List of patents (filed, Graduate School of Medicine/University Hospital, domestic sole application)● Number of collaborative research projects carried out with the private sector and amount received
Academic year
2007
2008
2009
2010
2011
2012

School of Medicine

School of Health Sciences

Number of projects

Amount received (Unit: 1,000 yen)

Number of projects

Amount received (Unit: 1,000 yen)

34
38
43
38
41
40

67,36974,20574,65376,35773,288
117,904

8
12
5
12
11
12

13,067
14,764
3,023
5,433
7,569
13,211

Note: Figures include researcher costs and business-academic collaboration costs (indirect costs)［Funded research ］●Number of projects/amount accepted for funded research expenses (including government-sponsored funds)
Academic year
2007
2008
2009
2010
2011
2012

School of Medicine
Amount received (Unit: 1,000 yen)
Number of projects
40
268,700
38
376,14965
514,37668
416,55869
811,45776
747,212School of Health Sciences
Number of projects
Amount received (Unit: 1,000 yen)
4
6,006
5
3,680
10
4,240
7
11,76911
23,56814
27,699Note: Including indirect expenses

For more information on collaborative/funded research,see the link below
http://www.med.nagoya-u.ac.jp/medical/1916/1917/index.html〈 Inquiries/administrative office in charge〉
School of Medicine/Graduate School of Medicine
Research Assistance Subsection
TEL：+81-52-744-2429 FAX：+81-52-744-2881
E-mail：iga-kenkyu@post.jimu.nagoya-u.ac.jp

Summary of Grant-in-Aid for Scientific Research［Summary of External Funds in 2012 academic year］
Categories

Number Amount receivedof project (Unit: 1,000 yen)

Categories

Number Amount receivedof project (Unit: 1,000 yen)

Grant-in-Aid for Scientiﬁc Research on Innovative
Areas (Research in a proposed research area)

36

586,142

Grant-in-Aid for Challenging Exploratory
Research (Fund-based Grant-in-Aid)

45

67,520Grant-in-Aid for Scientiﬁc Research (S)362,320Grant-in-Aid for Young Scientists (A)3

23,660Grant-in-Aid for Scientiﬁc Research (A)17101,670

Grant-in-Aid for Young Scientists (B)

8

7,020

Grant-in-Aid for Scientiﬁc Research (B)64

265,410Grant-in-Aid for Young Scientists (B) (Fund-based Grant-in-Aid)

77

136,630

Grant-in-Aid for Scientiﬁc Research (C)4439,235Grant-in-Aid for Research Activity Start-up

5

7,410

Grant-in-Aid for Scientiﬁc Research (C) (Fund-based Grant-in-Aid)

126

176,635

Grant-in-Aid for Encouragement of Scientists

4

2,300

Grant-in-Aid for Challenging Exploratory
Research

1

300

Grant-in-Aid for JSPS Fellows
Total

9

7,600

442

1,483,852*Including indirect expenses and number of grants/amounts awarded to co-investigators.
Data

63

News release
The Nagoya University Graduate School of Medicine selected
research achievements with particularly strong social impact
and published the details to the public as news. Within thegiven period, the following twenty-one projects werereleased:［List］
Date

Research details

Major investigators [Affiliation]*

May 7, 2012

Prof. OUCHI, Noriyuki [Department of Molecular Cardiology
Discovery of a beneﬁcial fat-derived hormone which is eﬀective for acute myocardial in- Endowed Chair: Kowa]
farction
KAMBARA, Takahiro (Graduate student)/Prof. MUROHARA,
Toyoaki [Department of Cardiology]

May 30, 2012Clariﬁcation of a molecular mechanism which causes cell migration in the spread of can- TAKAGISHI, Maki (Researcher)/Prof. TAKAHASHI, Masacer (invasion and metastasis) and recovery from injury
hide [Department of Tumor Pathology]

May 31, 2012

Development of novel therapeutic method by microRNA for neurodegenerative diseases‒Toward establishment of a novel therapeutic method for inhibiting the pathogenesis‒

Prof. SOBUE, Gen/MIYAZAKI, Yu (Graduate student) [Department of Neurology]*Joint research with Jichi Medical University

June 12, 2012

Discovery of a new cause of hereditary thrombosis

MIYAWAKI, Yuhri (Graduate student)/Assistant Prof. TAKAGI, Akira/Prof. KOJIMA, Tetsuhito [Program in Radiologicaland Medical Laboratory Sciences]Prof. MATSUSHITA, Tadashi [Department of Blood Transfusion Service]

June 13, 2012

Associate Prof. SUZUKI, Ritsuro [Department of HSCTEBV-DNA copy number in blood is useful for predicting the tumor response and the ocData Management and Biostatistics Endowed Chair: The
currence of adverse events in patients with NK-cell lymphoma treated with SMILE theraJapan Society for Hematopoietic Cell Transplantation]py
Associate Prof. KIMURA, Hiroshi [Department of molecular Virology]

June 28, 2012

Bone regeneration using stem cell derived cytokines‒Successful bone regeneration without cell transplant‒

July 23, 2012

Successful induction of reproduction of lymphatic vessels using subcutaneous adipose Prof. MUROHARA, Toyoaki/SHIMIZU, Yuuki (Graduate stutissue derived regenerative cells, and demonstration of improved lymphoedema in micedent) [Department of Cardiology]

July 27, 2012Clariﬁcation of the carcinogenic mechanism of asbestos-induced mesothelioma

August 30, 2012

Occurrence of chromosomal alterations similar to human cancer in animal carcinogenesis Assistant Prof. AKATSUKA, Shinya/Prof. TOYOKUNI, Shinmodels induced by iron overloadya [Department of Pathology and Biological Responses]

September 5, 2012

Prof. OUCHI, Noriyuki [Department of Molecular Cardiology
Discovery of the eﬀectiveness of a hormone secreted by the heart for acute myocardial Endowed Chair: Kowa]
infarction, and demonstration of eﬀectiveness in large animals
Prof. MUROHARA, Toyoaki/OGURA, Yasuhiro (Visiting researcher) [Department of Cardiology]

October 1, 2012

Prof. SOBUE, Gen/Associate Prof. KATSUNO, Masahisa/
Naratriptan, a headache medication, restrains polyglutamine-mediated degeneration of MINAMIYAMA, Makoto (Former Researcher) [Department ofmotor neuron through inhibition of CGRP-1 secretion
Neurology]*Joint research with the University of Tokyo

October 10, 2012

Heart failure as a complication of diabetes and clariﬁcation of a new mechanism

October 16, 2012

Prof. YAMAMOTO, Seiichi/Prof. KATO, Katsuhiko [Program
Successful development of PET/MRI combined high-resolution apparatus for small aniin Radiological and Medical Laboratory Sciences]
mal imaging*Joint research with Osaka University and Neomax Engi‒Promising for application to molecular imaging research including drug discovery‒neering Co., Ltd.

October 29, 2012

Prof. ISOBE, Kenichi [Department of Immunology]
Improvement of diabetic neuropathies by transplant of neural crest-like cells derived from
Former Associate Prof. NAKAMURA, Jiro/Prof. OISO, YutaiPS cells induced in senescence-accelerated miceka [Department of Endocrinology and Diabetes]

November 29, 2012

Regenerative treatment for periodontal disease using stem cell culture medium
Prof. UEDA, Minoru/Assistant Prof. KATAGIRI, Wataru/INU‒Successful regeneration of periodontal tissue without cell transplant; Clinical studies KAI, Takeharu (Graduate student) [Department of Maxillofainitiated in Nagoya University Hospital and so forth‒cial Surgery]

January 15, 2013

Prof. OZAKI, Norio/MATSUMOTO, Yurie (Graduate student)
Adolescent stress causes disorder in neural epigenetic mechanisms and aﬀects behavior- [Department of Psychiatry]
al patterns and the nervous system in adults*Joint research with Meijo University, Kyoto University, anda university in the U.S.

January 25, 2013

Prof. SOBUE, Gen/Associate Prof. KATSUNO, Masahisa/
The heat shock factor 1 (HSF-1) inﬂuences the pathological lesion distribution of spinal
KONDO, Naohide (Researcher) [Department of Neurology]
and bulbar muscular atrophy*Joint research with Yamaguchi University

February 27, 2013

Clinical Prof. MIZUNO, Masaaki [Nagoya University Hospital Center for Advanced Medicine and Clinical Research]
Changing body ﬂuid, interstitial ﬂuid, and culture medium into anticancer drugs by plasma Prof. KIKKAWA, Fumitaka [Department of Obstetrics and‒Clariﬁcation of new intracellular molecular mechanism of antitumor eﬀects by solution Gynecology]
irradiated with plasma‒*Joint research in Medicine-Engineering Collaboration with
Plasma Nanotechnology Research Center and NU Eco-Engineering Co., Ltd.

March 5, 2013

Center of Excellence (COE) Extraordinary Assistant Prof.
The receptor function of TLR4-MD-2 complex, the LPS receptor, is negatively regulated
KONDO, Yuji/Prof. FURUKAWA, Koichi [Department of Moby an endogenous ligand, globotetraosylceramide
lecular and Cellular Biology]

March 13, 2013

Prof. KAWABE, Tsutomu [Program in Radiological and MedDevelopment of clothes which can measure chest movement during breathing‒The ical Laboratory Sciences]"Knowledge Hub" Priority Research Project‒*Joint research in "Development of Early-Phase Diagnostic
Technology" for "Knowledge Hub Aichi"

March 18, 2013

FURUHASHI, Kazuhiro (former graduate student)/Associate
Adipose-derived mesenchymal stem cells cultured in low serum medium ameliorate cresProf. MARUYAMA, Shoichi/TSUBOI, Naotake (Lecturer)
centic glomerulonephritis by inducing immunomodulatory macrophages[Department of Nephrology]

Prof. UEDA, Minoru/Assistant Prof. KATAGIRI, Wataru/
OHSUGI, Masashi (Graduate student) [Department of Maxillofacial Surgery]

Prof. TOYOKUNI, Shinya/JUANG, Li (Researcher) [Department of Pathology and Biological Responses]

BANDO, Yasuko K.(Lecturer)/Prof. MUROHARA, Toyoaki[Department of Cardiology]*Titles and aﬃliations are at the time of publication of the News Release.

64

P r o f i l e M 2 013-2014

May, 2012 - March, 2013

［Commentary］
Discovery of a beneficial fat-derived hormone which iseffective for acute myocardial infarction

Clarification of a molecular mechanism which causes cell migrationin the spread of cancer (invasion and metastasis) and recovery from injury

Obesity is a risk factor for ischemic heart diseases—myocardial infarction, in particular—and its pathology is associated with fat-derived
hormones. Of them, the investigators focused on CTRP9 and demonstrated its myocardial protective effects in animal models of acute
myocardial infarction. The study showed that CTRP9 has antiapoptotic effects and is a beneficial fat-derived hormone which inhibits
acute myocardial disorder, suggesting that it can be a target moleculefor developing treatments for myocardial infarction

This study identified the molecular mechanism of non-canonical Wnt signaling
which causes the spread of cancer (invasion and metastasis) and showed that
Daple regulates the migration of cell population caused by the non-canonical
Wnt signaling pathway. In addition, the investigators revealed that this signaling regulation by Daple is important for the healing of skin wounds. It is hopedthat this clarification of the molecular mechanism will lead to the developmentof new therapeutic methods for inhibiting the invasion and metastasis ofcancer, in addition to the benefit of healing wounds.

Published in: The Journal of Biological Chemistry

Published in: Nature Communications

Development of novel therapeutic method by microRNA for neurodegenerative diseases–Toward establishment of a novel therapeutic method for inhibiting the pathogenesis–

Discovery of a new cause of hereditary thrombosis

The investigators developed a therapeutic method which enables inhibitionof the pathogenesis of spinal and bulbar muscular atrophy, a neurodegenerative disease, from a novel approach using a ribonucleic acid calledmicroRNA and adeno-associated virus vector. In addition, the investigators
revealed common mechanism associated with micro RNA between a mousemodel and humans. For the first time in the world, microRNA therapy wasapplied to this neurodegenerative disease; the method will potentially beapplied to other neurodegenerative diseases and used in clinical practice.

This study analyzed the unknown thrombotic causative factors that constitute the genetic risk of venous thrombosis and found that abnormality inprothrombin, a blood coagulation factor, which usually leads to bleeding,conversely causes thrombosis. It is hoped that the identification of thepathology of blood coagulation factors will result in the development of
new therapeutic methods and prophylaxis in thrombotic diseases including venous thrombosis, cerebral infarction, and myocardial infarction, theoccurrence of which is increasing in Japan as the population ages.

Published in: Nature Medicine

Published in: New England Journal of Medicine

EBV-DNA copy number in blood is useful for predicting thetumor response and the occurrence of adverse events inpatients with NK-cell lymphoma treated with SMILE therapy

Bone regeneration using stem cell derived cytokines–Successful bone regeneration without cell transplant–

In NK-cell lymphoma, fragmented DNA of EB virus is known topresent in peripheral blood. In this study, investigators analyzed
the EBV-DNA copy number in blood in participants of the SMILE
phase II study. The EBV-DNA copy number was useful not only
to predict the tumor response by SMILE therapy but also was
useful to predict the occurrence of adverse events.

Risks including malignant transformation of cells interfere with the wider application of stem cell transplants. For the first time in the world, this study succeeded
in bone regeneration using conditioned media from stem cells without performing transplantation, demonstrating that the transplant of cytokines only containedin the conditioned media from stem cells regenerates bone that is equivalent tothe bone regenerated by cell transplant. Concomitant use with existing bone
prosthetic materials is also possible and is expected to regenerate bone.

Published in: Clinical Cancer Research

Published in: Tissue Engineering Part A

Successful induction of reproduction of lymphatic vessels using subcutaneous adipose
tissue derived regenerative cells, and demonstration of improved lymphoedema in mice

Clarification of the carcinogenic mechanism ofasbestos-induced mesothelioma

This study demonstrated that the transplant of adipose derived regenerative cells(ADRC), which are promising novel stem cells for transplant in regenerative
medicine, to the tissue of lymphoedema enhances the regeneration of lymphatic
vessels due to ADRC accelerating the production of growth factors in the damaged
tissue, resulting in improvement of lymphoedema. The findings suggest that theregeneration of lymphatic vessels achieved by cell transplant may become a novel
therapy for lymphoedema, for which no radical treatment has been available to date.

The investigators showed that, in the carcinogenic process leading tothe onset of mesothelioma caused by all commercially-used asbestos
fibers (Asbestos), the pathology of iron overload is important. The
control over excess iron may lead to the prevention of carcinogenesis,
offering a hope to those who have been exposed to asbestos thatprophylactic strategies may be developed.

Published in: Journal of the American Heart Association

Published in: The Journal of Pathology

Data

65

News release［Commentary ］
Occurrence of chromosomal alterations similar to human cancer
in animal carcinogenesis models induced by iron overload

Discovery of the effectiveness of a hormone secreted by the heart for acute
myocardial infarction, and demonstration of effectiveness in large animals

Iron, if overloaded in a living body, causes a chemical reaction thatgenerates reactive oxygen species and causes oxidative stress to cells.
The study found that the oxidative stress-induced animal carcinogenesis model recapitulates chromosomal alterations equivalent to humancancers, suggesting the involvement of iron-induced oxidative stressas a common causative factor in general human cancers.

The investigators focused on a hormone secreted by the heart, FSTL1, and performed
systemic administration of human FSTL1 in small/large animal models of acute myocardial infarction before the occurrence of myocardial ischemia. The results showed attenuated myocardial infarct size and recovery of cardiac function, demonstrating the cardioprotective effect of human FSTL1. It was suggested that the administration of FSTL1 at
the time of acute myocardial infarction gives a cardioprotective effect, which may be atarget for the development of therapeutic agents for acute myocardial infarction.

Published in: PLoS ONE

Published in: Circulation

Naratriptan, a headache medication, restrains polyglutamine-mediateddegeneration of motor neuron through inhibition of CGRP-1 secretion

Heart failure as a complication of diabetes andclarification of a new mechanism

This study showed that naratriptan—a therapeutic drug for migraine—
inhibits polyglutamine-related motor neurodegeneration in spinal and bulbar
muscular atrophy, a neurodegenerative disease, via inhibiting the release of
CGRP1 which is closely associated with the pathogenesis of the disease. This
has resulted in clarification of the pathological mechanism of the disease anddevelopment of a therapeutic method. It is promising that these findings will
be applied to other neurodegenerative diseases for which no effective
treatment has been reported thus far, and will be used in clinical practice.

The investigators identified that abnormal activity of serine protease DPP4, which isexpressed in coronary microvessels, is one of the causes of cardiac diastolic
dysfunction (cardiac dilatation dysfunction), which is recognized as a complicationof diabetes mellitus. Thus, the study demonstrated in an animal model that DPP4
inhibitors, which are therapeutic drugs for diabetes mellitus, improve cardiac
dilatation dysfunction via the action of improving diabetic cardio/microvascularinsufficiency, suggesting that interventional treatment for cardio/microvascularinsufficiency may be an effective therapy for cardiac dilatation dysfunction.

Published in: Nature Medicine

Published in: Circulation

Successful development of PET/MRI combined high-resolution apparatus for small animal imaging–Promising for application to molecular imaging research including drug discovery–

Improvement of diabetic neuropathies by transplant of neural crest-likecells derived from iPS cells induced in senescence-accelerated mice

In collaboration with Neomax Engineering Co., Ltd., the investigators succeeded indeveloping a PET/MRI integrated high-resolution apparatus for small animal imaging,which enables simultaneous imaging of positron-emission tomography (PET) andmagnetic resonance imaging (MRI). With the device, high-contrast MRI images and the
distribution of positron-emitting isotopes can be obtained for the same site and simultaneously. In the future, the apparatus will be useful in molecular imaging research using
small animals for drug discovery and so forth. The device also offers commercial
potential as the world's first PET/MRI combined apparatus for small animals.

The investigators found that transplant of neural crest-like cells (NCL
cells) derived from iPS cells induced in senescence-accelerated miceis effective for diabetic polyneuropathy (DPN). The study showed thatthe findings may be applied to regenerative medicine utilizing iPS cells
for advanced DPN, for which no effective therapy has been discovered
to date. The study also suggested that even iPS cells collected fromthe aged are useful for regenerative medicine for complications ofdiabetes mellitus.

Published in: Medical Physics

Published in: Cell Transplantation

Regenerative treatment for periodontal disease using stem cell culture medium–Successful regeneration of periodontal tissue without cell transplant; clinicalstudies initiated in Nagoya University Hospital and so forth–Adolescent stress causes disorder in neural epigenetic
mechanisms and affects behavioral patterns
and the nervous system in adults

In the transplantation of stem cells, the risk of malignant transformation of cells, cost, andvarious other limitations have hindered wider implementation. The investigators, for the firsttime in the world, succeeded in regenerating periodontal tissue without performing stem
cell transplant using conditioned medium from the cultured stem cells, thus finding that the"regeneration factors" including cytokines secreted from stem cells induce stem cells in the
body to regenerate periodontal tissue. These regeneration factors can be formulated into
preparations, which may lead to drug discovery for the treatment of periodontal disease.

With regard to the mechanism by which interactions between genetic factors andenvironmental factors in childhood influence adulthood, the study showed that a continuous epigenetic change that occurred in the dopaminergic nervous system in the brain via
an increase in levels of stress hormones influences behavioral patterns in adulthood. It is
hoped that the findings will lead to countermeasures for psychiatric disorders, stimulating studies on the mechanism of occurrence of psychiatric disorders and the development of prophylactic methods to prevent onset as well as therapeutic agents.

Published in: Biochemical and Biophysical Research Communications

Published in: Science66

P r o f i l e M 2 013-2014

May, 2012 - March, 2013

［Commentary ］
The heat shock factor 1 (HSF-1) influences
the pathological lesion distribution of
spinal and bulbar muscular atrophy

Changing body fluid, interstitial fluid, and culture medium
into anticancer drugs by plasma–Clarification of new intracellular molecular mechanism ofantitumor effects by solution irradiated with plasma–

While neurodegenerative diseases are characterized by pathological lesion
selectivity, the molecular mechanism was unknown. This study showedthat the heat shock factor 1 (HSF-1) influences the lesion distribution in
spinal and bulbar muscular atrophy, a neurodegenerative disease. Deletionof HSE-1 expanded the pathological lesion of this disease, while overexpression of HSE-1 mitigated the pathology. In the future, further studies onother neurodegenerative diseases and clinical application are anticipated.

In the framework of "Plasma Medical Innovation", a Scientific Research on Innovative Areas
supported by the MECSST, the investigators developed a technology which may cure disseminated carcinoma (intrathecal dissemination, intra-abdominal dissemination) for which noeffective therapeutic methods have been found, using non-equilibrium atmospheric pressureplasma which was independently developed by the investigators, in addition to ordinary solid
tumors. It is hoped that, in the future, the intracellular molecular mechanism will be identified in
more detail and the findings will be applied to plasma medicine based on scientific principles.

Published in: Nature Communications

Published in: Plasma Medicine Journal

The receptor function of TLR4-MD-2 complex,
the LPS receptor, is negatively regulatedby an endogenous ligand, globotetraosylceramide

Development of clothes which can measure chest
movement during breathing–The "Knowledge Hub" Priority Research Project–

Lipopolysaccharides (LPSs), the component of Gram-negative bacilli,
act primarily on vascular endothelial cells and elicit lethal injurious
effects. The investigators showed that globotetraosylceramide (Gb4), a
globo-series glycosphingolipid, attenuates the action of LPSs by binding to the LPS receptor, TLR4-MD-2. In addition, the study of Gb4
injection after LPS infusion suggested that Gb4 may be used to treat
endotoxic shock.

In a joint research "Development of Early-Phase Diagnostic Technology" for the "Knowledge Hub Aichi" Priority Research Project, theinvestigators developed a new type of system which enables thedetection of breathing conditions by installing sensor functions inclothes. The developed product is made of the same material as
ordinary clothing and can measure the breathing movements of thechest during activities in daily living. It is hoped that the product will be
used for the management of breathing functions and monitoring of
exercise.

Published in: Proceedings of the National Academy of Sciences USA

Adipose-derived mesenchymal stem cells cultured in low
serum medium ameliorate crescentic glomerulonephritis
by inducing immunomodulatory macrophages
The investigator showed in animal experiment that special preparation of
adipose tissue-derived stem cells (called LASC), obtained by a unique low
serum culture method, are highly effective for the treatment of rapidly progressive nephritis which may require dialysis. Thus, the study demonstrated that, as
one of therapeutic mechanisms, LASC decreases inflammatory macrophages
and increases immunomodulatory macrophages. It is hoped that administration of LASC in patients with rapidly progressive nephritis may attenuate tissue
injury at local sites efficiently while decreasing systemic adverse reactions.
Published in: Journal of the American Society of Nephrology

For more News Releases, see the link below
http://www.med.nagoya-u.ac.jp/english01/3403/3407/index.html

Data

67

Extension courses at Tsurumai Campus
Since 2005, the School of Medicine and the University
Hospital have co-hosted Extension Courses at Tsurumai
Campus annually as open seminars for the public. These
focus on topics of modern interest and that are useful foreveryday life.
The seminars are attended by a wide range of people fromthose in their 20's to 80's, and the number of repeat
attendees is steadily increasing.

Every seminar attracts an eager audience who are keen to
ask questions, reflecting people’s strong interest in thesecourses.
The Extension Courses at Tsurumai Campus provide a
valuable forum for social exchange among the School of
Medicine, the University Hospital, and the general public.
Thus, we are playing an important role in connecting withthe local community and contributing to society.

［ History of extension courses at Tsurumai Campus］
Academic year
2005
2006
2007
2008
2009

SeminarDate

In the news! What is metabolic syndrome?
Ever-evolving cancer treatments: Heartening news and a good education
Futuristic treatments within our grasp ― is it really possible?!
Breakthroughs with our aging population ― You’re getting older and so am I
Building sound body and mind to stay independent

Number of participants

December 10

About 100

October 29

85

October 27

65

October 4

About 130

November 21

About 200

［Extension courses held during 2010 academic year ］
Food: A direct path to health〈 Date〉 November 20, 2010
〈 Number of people participated 〉 about 230

In Japan, the cost of social security benefits packages including medicalcare coverage have reached a record level, making disease prevention
more important than ever. To respond to this trend, the three lecturers
gave seminars on the topic of “nutrition”, as one of the three coreelements of health. Nutrition can also be thought of as “diet”.
“Lifestyle-related Diseases: Better or worse, it depends on what and how
you eat”, SUZUKI, Tomio, Deputy Director, Department of ClinicalNutrition / “Compatibility of Medicines and Foods – Learn from the
Mechanism –”, YANO, Kohji, Chief for the Department of Hospital
Pharmacy / “Issues regarding Nutrition for the Elderly, Especially Eating
Disorders and Malnutrition”, Associate Prof. KUZUYA, Masafumi［Extension courses held during 2011 academic year ］
What is Constitution?
Its relationship with drug efficacy
and lifestyle diseases〈 Date〉 November 19, 2011
〈 Number of people participated 〉 about 180

People’s constitutions vary significantly; the differences are classified into
those due to “heredity”, and those due to the “environment”. Recent
progress in science has revealed many facts regarding genetic
constitution. The three lecturers gave seminars focusing on “genetic
constitution”.
“Genetic constitution: The findings so far”, Prof. HAMAJIMA, Nobuyuki /“Effects of Drugs and Genetic Constitution—Personality that Decides Drug
Effectiveness”, ISHIKAWA, Kazuhiro, Deputy Manager for the Departmentof Hospital Pharmacy / “Lifestyle and Genetic Constitution—Which isstronger?”, Associate Prof. HAMADA, Yoji, Endowed Chair［Extension courses held during 2012 academic year ］
Disease Prevention:
For Healthy Ageing

The three lecturers gave seminars covering broad areas, ranging fromfamiliar topics such as diseases of the elderly in a society of longevity,
cancer and so forth, to the current situation of healthcare in the world
including developing countries.

〈 Date〉 November 17, 2012

“Prevention of Diseases and Frailty in the Aged in a Society of Longevity”,
Prof. KUZUYA, Masafumi / “Prevention of Cancer in a Society ofLongevity”, Prof. HAMAJIMA, Nobuyuki / “Thinking of World Health”,
Prof. AOYAMA, Atsuko〈 Number of people participated 〉 about 150

68

P r o f i l e M 2 013-2014(The job title is a thingat the time of the lectures)

Locations
Locations

Tsurumai Campus

Traveling time

Traveling time

25 min.

30 min.

(via subway/JR line)(via subway/JR line)

Traveling time

Higashiyama Campus

20 min.

Daiko Campus(via subway)

69

Tsurumai Campus map
Tsurumai Campus map

Bus StopK

E

F

Cafeterias & Shops
J

D❺

Car Entrance

G

❹
H

❻

❼

❷

B

Bicycle-parking area
A❶
Parking❸❽❾
Parking

ParkingI

Meikodai-mae
University Hospital

Graduate School of Medicine/School of Medicine❶ Outpatient Building

A

Medical Science Research Building 1❷ Central Consultation Building

B

Medical Science Research Building 2❸ Ward Building

D

Basic Medical Research Building❹ Residence for Nurses A

E

Basic Medical Research Building Annex❺ Residence for Nurses B

F

Center for Promotion of Medical Research and Education (Experimental Animals Division)❻ Old Ward Building WestG

Medical Library / Co-op Cafeteria❼ Old Ward Building East

H Welfare Facility❽ Oasis Cube (welfare facility)

I

Kakuyu Kaikan (Alumni Hall)JRadioisotope Research Center

2

Central Consultation Building K Human
4F・7 F Anatomy
Facilities
Management Group
Laboratory

Personnel Affairs and Labor Group1

Outpatient Building

Student Affairs
Affairs Division
Division
General2
D

Basic Medical
Research
Building
CentralConsultation
Building

Management
and Planning
Personnel
Affairsand LaborDivision
Group

1

General Affairs Division

Outpatient Building

4F

Hospital Affairs Division1

Outpatient Building

1F

1F
4F
・7 F

Medical Service
DivisionGroup
Facilities
Management

2
1

Central Consultation
Outpatient
Building Building

2F
4F

Outpatient Building

4F

Clinical History
Management
Hospital
Affairs
DivisionSection

1

Outpatient Building

4F
1F

Accounting
Division
Student
Affairs
Division

1
D

Outpatient
Building
Basic
MedicalResearch Building

4F
1F

Medical Service Division

2

Management and Planning Division1

Outpatient Building

4F

Central Consultation Building(as of April 1,2F2013)

Clinical History Management Section

1

Outpatient Building

Accounting Division1

Outpatient Building

4F70

P r o f i l e M 2 013-2014

4F

1

4F

(as of April 1, 2013)[ Guide map for Graduate School of Medicine/School of Medicine ] (as of May 1, 2013)
Dermatology,

13F Plastic and Reconstructive Surgery,
Pediatric Surgery

Orthopedic Surgery, Rheumatology,

12F Otorhinolaryngology
Ophthalmology,

11F Oral and Maxillofacial Surgery
10F
9F
8F

Psychiatry, Neurosurgery

Gastroenterology and Hepatology,
Nephrology, Neurology
Radiology, Infectious Diseases, ClinicalManagement Medicine, Department ofClinical Oncology and Chemotherapy
Hematology, Cardiology,
Pathology and Laboratory Medicine

Public Health and Health Systems,
Occupational and Environmental Health,Division for Medical Research Engineering,
Global COE Promotion Office

Respiratory Medicine,

Preventive Medicine, Physiology 1,
Physiology 2

Obstetrics and Gynecology, Pediatrics

Immunology, Cancer Biology,
Molecular Carcinogenesis

Urology, Anesthesiology

Pharmacology, Bacteriology,
Neurogenetics

Lecture Room 3, Lecture Room 4

3F

Gastroenterological Surgery 1,
Vascular Surgery, Cardiac Surgery,
Thoracic Surgery

Biochemistry 1, Biochemistry 2,
Molecular Virology

Department of Renal Replacement Therapy,
Department of Metabolic Medicine,
Department of Transplant Immunology, Biochemistry 2,
Cardiology, Lecture Room 1, Lecture Room 2, Seminar Room

2F

Pathology 1, Pathology 2, Anatomy 1
Gastroenterological Surgery 2,
Transplantation Surgery, Breast and Endocrine
Surgery, Emergency and Critical Care Medicine

Department of Molecular Cardiology Endowed Chair: Kowa,
Department of Advanced Research of Gastroenterology,
Human Nutrition, Molecular Pathology,
Seminar Room, Lounge

General Medicine,

Office of International Affairs,
Young Leaders’ Program (YLP), Meeting Rooms,
Changing Rooms, Administration Office

7F

6F Endocrinology and Diabetes, Geriatrics
5F
4F

1F Department of Hospital Pharmacy,
Convenience store

B1F

Anatomy 2, Anatomy 3,
Legal Medicine and Bioethics,
Division for Medical Research Engineering

Meeting Room, Hand Surgery

Medical Science Research Building 1

Medical Science Research Building 2

Basic Medical Research Building

Locations71

Daiko Campus map
Daiko 3 - Chome S.

Yada Jr.H.S.N

❼
❾

❷
❸
❶

❻

❺
❹

❿
❽
⓫

⓬

❶ School of Health Scienses (South Building)

Bus Stop❷ School of Health Scienses (Main Building)Cafeterias & Shops❸ Gymnasium

Car Entrance❹ Radioisotope Laboratory

Entrance❺ Energy Center❻ Student Hall
❼ School of Health Scienses (Annex)❽ Kyudo (Japanese Archery) Hall
❾ School of Health Scienses (East Building)❿ Researchers Village Daiko⓫ Tennis Court⓬ Ground72

P r o f i l e M 2 013-2014

Land and buildings
Land andand buildings
buildings
Land
Tsurumai Campus
Tsurumai
Location 65 Tsurumai-cho, Showa-ku, Nagoya
Tsurumai Campus
CampusArea (land) 89,137m 2
Area (land) 89,137m 22
Area (land) 89,137m

Location 65 Tsurumai-cho, Showa-ku, Nagoya
Location 65 Tsurumai-cho, Showa-ku, Nagoya

Buildings ［building area］35,252m 2 ［total floor area］202,139m 2
2
Buildings ［building area］
total floor area］202,139m 22［total floor area］202,139m
Buildings ［building area］35,252m
35,252m 2 ［Name of building

Architecture

Building area (m2)

Total floor area (m2)

RC4

5,309

19,446

SRC7-2

5,881

43,612❸ Ward Building

S14-2

4,721

52,297❹ Residence for Nurses A

SRC10

675

6,158

❶ Outpatient Building❷ Central Consultation Building❺ Residence for Nurses B

RC6

563

2,741

❻ Old Ward Building West

RC6-1

1,584

14,525❼ Old Ward Building East

〈Included in Old Ward Building West〉❽ Oasis Cube (Welfare Facility)

S1

604

595

A Medical Science Research Building 1

S13-2

1,493

20,875

B Medical Science Research Building 2

RC7

1,515

10,300D Basic Medical Research Building

RC4-1

1,651

6,585

E Basic Medical Research Building Annex

RC5

695

3,158

F Center for Promotion of Medical Research and Education (Experimental Animals Division)

RC7-1

889

6,488

G Medical Library / Co-op Cafeteria

RC4-1

974

3,138

H Welfare Facility

RC3

308

760

I Kakuyu Kaikan (Alumni Hall)

RC3

550

1,354

J Radioisotope Research Center

RC4・RC2

695

1,803

K Human Anatomy Laboratory

RC1

Others

301

301

6,844

8,003

35,252

Total

202,139(as of April 1, 2013)

Daiko Campus
Daiko
Location 1-20 Daiko-Minami 1-chome, Higashi-ku, Nagoya
Daiko Campus
CampusArea (land) 48,463m 2

Buildings ［building area］10,470m 2 ［total floor area］28,429m 22)(m2) 22Namebuilding 1-chome, Higashi-ku, Nagoya Architecture
floor］area
Area (land) 48,463m 22
Location
1-20 of
Daiko-Minami
Buildings ［building Buildingarea］ area 22(mtotalTotal
floor area
28,429m［total floor area］28,429m
Area (land) 48,463m
Location 1-20 Daiko-Minami 1-chome, Higashi-ku, Nagoya Buildings ［building area］10,470m
10,470m ［❶ School of Health Sciences((South Building))
RC4
3,021
8,067

❷ School of Health Sciences((Main Building))

RC5

1,414

5,835

❸ Gymnasium

SRC1

1,369

1,369

❹ Radioisotope Laboratory

RC1

353

353

❺ Energy Center

RC2

606

894

❻ Student Hall

RC2

678

1,338

❼ School of Health Sciences((Annex))

RC4

579

2,431

88

88

❾ School of Health Sciences((East Building))

RC4

843

3,331

10 Researchers Village DAIKO●
11 Tennis Court●
12 Ground
●

RC3

280

720

−

−

❽ Kyudo (Japanese Archery) Hall

Others
Total

−

−

1,239

4,003

10,47028,429(as of April 1, 2013)
Locations73

Access map
Transportation Guide

Mission of the Nagoya University School of Medicine
For Kyoto・Osaka

Tokaido Line
Tokaido Shinkansen

For Inuyama・shin-unuma
Gifu
For Inuyama

Access to

Centr(Central Ja
International

Komaki

Kami Otai

JR Chuo Line

Kamiiida

For Tajimi・Nagano

To develop cutting-edge medical research thatNagoya
willDomecontribute to an
improvement in the
Owariseto
Heian-doriSunada-bashi
mae Yada
health of mankind and to create new medicalOzone
technology.
NagoyaTakabata

For Osaka

Nakamura
Kuyakusho

Marunouchi

Nagoya University
Daiko Campus

Hisayaodori

FushimiSakae

Chikusa

ImaikeMotoyama

Nagoya University
Tsurumai Campus Nagoya

JR Kansai Line

Daigaku

Kamimaezu

Tsurumai

GokisoHigashiyama
Koen(Central Ja
International
Fujigaoka

Nagoya University
Higashiyama Campus
YagotoAkaikeFor Toyota

Kanayama

Subway Tsurumai Line

Subway Meiko Line

Tokushige
Nagoyako

Aonami Line

Tokaido Line
Tokaido Shinkansen

For Toyohashi
For Toyohashi・
Shizuoka・Tokyo

To enhance the quality of local medical services in cooperation with local institutions,both in medical research and medical care, and to improve medical care standards inJapan and the world.
CentrairTo Tsurumai Campus● Take the JR Chuo Line to Tsurumai Sta. (Meidai Hospital exit), then walk 3 min.
● Take the Subway Tsurumai Line to Tsurumai Sta., then walk 8 min.
● Take the City Bus from Sakae Terminal to Meidai Byoin bus stop via Sakae Route No. 18 bound for Myoken-cho

To Daiko Campus● Take the JR Chuo Line to Ozone Sta. (North gate), then walk 15 min.

● Take the Subwayand
Meijo medical
Line to Nagoyaprofessionals
Dome-mae Yada Sta.,who
then walk
10 min., medical ethics, andTo foster medical researchersrespector to Sunada-bashi Sta., then walk 7 min.
take pride in contributing
to Busthefrom
welfareof mankind.
● Take the City
Ozone Terminal
to Daiko 3-chome bus stop via

Meieki Route No. 15 bound for Sunada-bashi● Take the Guideway Bus to Nagoya Dome-mae Yada Sta., then walk 10 min.,or to Sunada-bashi Sta., then walk 7 min.

To Higashiyama Campus● Take the Subway Meijo Line to Nagoya Daigaku Sta.
● Take the City Bus from Sakae Terminal to Nagoya Daigaku bus stop via

Sakae Route No. 16/17 bound for Nagoya Daigaku

Logo
A combination of three cranes, symbolizing love (humanity), harmony (partnership),and honesty (good faith) respectively.
This symbol represents the essence of healing and diligent medical study
that physicians must embrace and hand down to the next generation.

74

P r o f i l e M 2 013-2014

Shin-Os
StatioCentr

TokyStatioAratama-bashi

Subway Meijo Line
Kinjo Futo

Toky
Statio(Central Ja
International

Subway Sakura-dori Line

Subway Kamiiida Line

Shin-Os
StatioCentr

To develop
an open system to utilize sources of talented people which can serve as the
JR LineMeitetsu Linehub for medical
research and medical care.
Kintetsu Line
Subway Higashiyama Line

Toky
StatioShin-Os
StatioPublished October 2013
Prepared and edited byGeneral Affairs & Planning Section, General Affairs Division
Nagoya University School of Medicine and Graduate School of Medicine
TEL: +81-52-744-2228