Product Safety Summary for Dodecanedioic Acid
SUBSTANCE NAME
Dodecanedioic acid
1,10-Decanedicarboxylic acidalpha,omega-DC12
C12 acid
DDA

GENERAL STATEMENT

Dodecanedioic acid is a white solid with a slight odor. At 20°C, the relative density is 1.172, which is higher
than that of water, and the vapor pressure is 0.000000015 Pa. Dodecanedioic acid has a wide range ofapplications. Dodecanedioic acid is used as a raw material for polyurethane, polyester, and polyamide resins,
as well as a hardener for acrylic powder paints.
Dodecanedioic acid is not known to cause remarkable adverse human health or environmental effects, but it
causes serious irritation to eyes. Exposure via eye contact must be avoided, specifically by industrial users
and certain professional users. Always protective goggles should to be worn. If dust formation is possible
during operations adequate ventilations or half mask respirators with dust filters is required.
General population will not come in contact significantly with this chemical via environment due to the
production of the substance as Dodecanedioic acid is manufactured in closed processes which also minimizes
exposure potential to workers. No significant exposure to the environment is expected. The substance is notintended for consumer uses. The usual general precautionary measures to prevent worker andenvironmental exposure to chemicals should also be taken when handling Dodecanedioic acid in industrial
uses.

CHEMICAL IDENTITYEC Name:
EC-No. :CAS-No. :Molecular formula:
Structural formula:

Dodecanedioic Acid
211-746-3
693-23-2
C12H22O4

USES AND APPLICATIONS
Dodecanedioic acid is used as a raw material for polyurethane, polyester, and polyamide resins, as well as ahardener for acrylic powder paints. When reacted with various alcohols and diamines, DDA produces
polyester and polyamide resins with excellent performance, especially in hydrolytic resistance, flexibility, andheat stability.

PHYSICAL CHEMICAL PROPERTIES

Dodecanedioic acid is a white solid with a slight odor. At 20°C, the relative density is 1.172, which is higher
than that of water, and the vapor pressure is 0.000000015 Pa. The melting point of this substance is 128°C
and the boiling point 250°C. Since the substance does not react with water or contain any groups that might

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Product Safety Summary for Dodecanedioic Acid
oxidize or spontaneously ignite, it is not expected that Dodecanedioic acid would be flammable, self-ignite,oxidize or explode at ambient conditions.
Melting point/range:
128 °C at 1013.25 hPa
Boiling point/boiling range:
250 °C at 13.33 hPa.
Decomposition temperature: >250 °C
Flammability (solid, gaseous): not highly flammable
Explosive properties:
non-explosive
Auto-ignition temperature:
Not applicable.
Molecular weight:
230.300 g/mol
Water solubility:
30 mg/l solution at 20°C
logPow:
3.2 at 25°C
Vapor pressure:
0.000000015 Pa at 20°C
Relative density:
1.172 g/cm3 at 20°C
Oxidizing properties:
No oxidizing properties

HEALTH EFFECTS

Dodecanedioic acid has no marked health hazard properties. Based on available data, Dodecanedioic acid has
no relevant acute toxicity if swallowed or in contact with skin after a one-time exposure. Due to a low vapor
pressure, inhalation exposure is unlikely; therefore, no data is available. Dodecanedioic acid causes serious
irritation to eyes but it is not irritating to skin. Based on available data the substance is not considered to be askin sensitizer. Standard tests indicate Dodecanedioic acid is not mutagenic nor genotoxic. Available data
show no evidence that the substance is carcinogenic. Based on available data there is no evidence thatDodecanedioic acid is a reproductive or developmental toxin. After repeated oral ingestion Dodecanedioic
acid showed no relevant toxic effects up to the highest doses tested.
EFFECT ASSESSMENT
Acute Toxicity(oral/dermal/inhalation)
Irritation/Corrosivity(skin/eye/respiratory tract)
Sensitization (skin/respiratory tract)(skin/respiratory tract)
Mutagenicity
Carcinogenicity

Reproductive Toxicity

Repeated Dose Exposure

ENVIRONMENTAL EFFECTSRESULT
Dodecanedioic acid is of low acute toxicity via all routes ofexposure.
Dodecanedioic acid is serious irritating to the eyes.
Dodecanedioic acid is not irritating to the skin.
Based on the available data Dodecanedioic acid is not considered
to have skin or respiratory sensitization properties.
All available in vitro test data indicates that Dodecanedioic aciddoes not cause mutagenic effects.
No carcinogenicity data has been generated due to the negative
mutagenicity results.
Screening test information indicates that Dodecanedioic acid has
no adverse reproductive effects.
Oral repeated dose test results with Dodecanedioic acid suggestthat no marked toxicity should be expected. Dermal and inhalation
repeated dose exposure testing is considered unnecessary basedon expected exposure routes and the result of the oral repeateddose test.

The results of all acute aquatic studies on fish, algae, plants and invertebrates indicate a low environmental
acute hazard potential for Dodecanedioic acid. Dodecanedioic acid is readily biodegradable and it has a low
bioaccumulation potential. Considering all available data on biotic and abiotic degradation, bioaccumulation

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Product Safety Summary for Dodecanedioic Acidand toxicity, it can be stated that the substance is neither persistent nor toxic to the environment and that it
will not bio-accumulate. Overall, Dodecanedioic acid has a low environmental hazard potential.
EFFECT ASSESSMENT
Aquatic Toxicity
FATE AND BEHAVIOR
Biodegradation
Bioaccumulation potential
PBT/vPvB conclusion

EXPOSURE

RESULTFish, daphnia, algae and plant studies indicate that the aquatic
toxicity of Dodecanedioic acid is low.

RESULT
Dodecanedioic acid is readily biodegradable.
Dodecanedioic acid has a low bioaccumulation potential.
Based on its low toxicity, bioaccumulation potential and readybiodegradability, Dodecanedioic acid does not meet the criteria for
PBT or vPvB.

Human Health
Dodecanedioic acid is used in many different applications. In industrial sites, it is used as a raw material forpolyurethane, polyester, and polyamide resins, as well as a hardener for acrylic powder paints. When reactedwith various alcohols and diamines, Dodecanedioic acid produces polyester and polyamide resins withexcellent performance, especially in hydrolytic resistance, flexibility, and heat stability. But its main industrial
use is as monomer or reactant; therefore, Dodecanedioic acid will no longer be present as such indownstream products, practically eliminating the exposure potential for consumers. General population will
not come in contact significantly with this chemical via environment due to the production of the substance as
Dodecanedioic acid is manufactured in closed processes which also minimizes exposure potential to workers.
The direct exposure of general population is very unlikely as this substance is manufactured in industrial
settings for industrial / professional use. Normal industrial practices assure limited workplace exposures.

Environment
The manufacture is a closed process and no significant exposure to the environment is expected.
Dodecanedioic acid is solid at room temperature and it has low volatility in liquid form above its boilingpoint. Therefore, the probability of release in pure form to any of the environmental compartments is low,
under normal industrial use conditions. There may be some release to waste water streams as a result ofnormal use or industrial operations. Due to its readily biodegradability, Dodecanedioic acid should not cause
further environmental exposure. Any exposures will generally be lower than concern levels. Direct use by thegeneral population is not intended and thus environmental exposure via this route is unlikely to occur.

RISK MANAGEMENT RECOMMENDATIONS

Dodecanedioic acid poses a risk that need to be managed. Exposure via eye contact must be avoided,
specifically by industrial users and certain professional users. Always protective goggles should to be worn. If
dust formation is possible during operations adequate ventilations or half mask respirators with dust filters
is required. Do not eat, drink, smoke where chemicals are handled, processed or stored. Wash hands and skinfollowing contact. If the substance gets into your eyes, rinse eyes thoroughly for at least 15 minutes withwater and seek medical attention. Dodecanedioic acid is not flammable; however, it is good practice toprevent the build-up of electrostatic charge when storing it. For environmental protection in case of
accidental release: do not allow product to reach sewage system or any water course. Retain and dispose ofcontaminated wash water. Releases to air should be avoided by suitable measures.
Dodecanedioic acid poses low human health and environmental risks. However it is a good practice to train
personnel handling the substance and to protect workers who may be exposed to Dodecanedioic acid bytaking the usual precautionary measures to protect against chemical exposure.

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Product Safety Summary for Dodecanedioic Acid
STATE AGENCY REVIEWThis substance has been registered under REACH (EC) No. 1907/2006.
Dodecanedioic acid is included in the OECD list of High Production Volume (HPV) chemicals.
Dodecanedioic acid is listed in the following Chemical Inventories: TSCA, EINECS, ENCS, AICS, Canadian DSL,KECI, PICCS, IECSC, and NZIoC.

REGULATORY INFORMATION/CLASSIFICATION AND LABELINGClassification of the substance according to REGULATION (EC) No 1272/2008:
Skin/Eye(Corrosion/irritation):

Category 2; H319 Causes serious eye irritation.

Labeling according to REGULATION (EC) No 1272/2008:

Pictogram:

Signal word:

Warning

Hazard statements:

H319: Causes serious eye irritation.

CONTACT INFORMATION WITHIN COMPANY

For further information on this substance or product safety summaries in general, please contact:

Company:
Department:
Address:
Town/Country:
Postal code:
E-mail:UBE Chemical Europe, S.A
Product Liability
Poligono Industrial El Serrallo, s/nGrao de Castellon (Castellon), Spain
12100
sds.ube.eu@ube.es

Additional information can be found at:
http://www.ube.es
http://www.icca-chem.org/en/Home/ICCA-initiatives/global-product-strategy/

GLOSSARY
Acute toxicity

BiodegradationBioaccumulation

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Harmful effect resulting from a single or shortterm exposure to a substance.
Decomposition or breakdown of a substance undernatural conditions (actions of micro organismsetc).
Progressive accumulation in living organisms of aPage 4

Product Safety Summary for Dodecanedioic Acid
Canadian DSL
Carcinogenicity
CAS

Chronic toxicity
EINECS

Flash point

Genotoxicity
GHS

HPV
Hydrolyze

Intermediate
Monomer
Mutagenicity
PBT
Persistence

Risk Management Measures
REACH (EC) No. 1907/2006
REGULATION (EC) No 1272/2008
Reprotoxicity
Sensitizing
Sediment

TSCA
Vapor pressurevPvB

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chemical substance present in the environment.
Domestic Substances List of Canada.
Substance effects causing cancer.
Chemical Abstracts Service (division of theAmerican Chemical Society).
Harmful effect after repeated exposures or longterm exposure to a substance.
European Inventory of Existing Commercial
Chemical Substances
The lowest temperature at which vapor of thesubstance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Globally Harmonized System of Classification andLabelling of Chemicals
High Production Volume Chemicals.
Undergo hydrolysis; decompose by reacting withwater.
Substance that is manufactured for and consumed
in or used for chemical processing in order to betransformed into another substance.
Means a substance which is capable of forming
covalent bonds with a sequence of additional likeor unlike molecules under the conditions of therelevant polymer-forming reaction used for theparticular process.
Substance effect that cause mutation on genes.
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Engineering controls, conditions and protective
equipment needed to be implemented to ensurethat the risks to human health and theenvironment are adequately controlled.
European Commission Regulation concerning theRegistration, Evaluation, Authorisation andRestriction of Chemicals.
European Commission Regulation onClassification, Labelling and Packaging ofSubstances and Mixtures.
Including teratogenicity, embryotoxicity andharmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom ofrivers and sea.
Toxic Substance Control Act
A measure of a substance’s property to evaporate.
Very persistent, very bioaccumulative.

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Product Safety Summary for Dodecanedioic Acid
DATE OF ISSUE
March 2016

REVISION
Version 1.0

DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information isprovided in utmost good faith and has been based on the best information currently available, is to berelied upon at the user’s own risk. No representations or warranties are made with regards to its
completeness or accuracy and no liability will be accepted by UBE Chemical Europe, S.A for damages of
any nature whatsoever resulting from the use of or reliance on the information.

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