Name
Assist. Prof. Pennapa Chonpathompikunlert
Research Officer (Sub 2 band 2) at Expert Centre of Innovative Health Food
(InnoFood), Thailand Institute of Scientific and Technological Research (TISTR),
35 Mu 3 Technopolis, Khlong Ha, Khlong Luang, Pathum Thani 12120, Thailand
Tel: +66909613029
E-mail: pennapa@tistr.or.th
pennapa23@gmail.com

Education
2000-2004 B.Sc. (Physical Therapy), Second Honour.
Faculty of Associated Medical Sciences, Khon Kaen University,
Thailand.
Term Project: The effect of touch massage on gross motor development in preterm infants – a pilotStudy2005-2009 Ph.D. (Neuroscience Program) Faculty of Medicine, Khon Kaen
University, Thailand.
Thesis: Potential of piperine delivery with nanotechnology to protect against Alzheimer’s disease
Research experiences
05/2009-05/2011 Post-doctoral fellow in TIMS (Tsukuba ResearchCenter for Interdisciplinary Materials Science), University ofTsukuba, Japan
Project: Polymeric nanoparticle delivery to treatment brain diseases
06/2011-05/2012 Research scientist in Graduate School of Pure andApplied Science of Tsukuba, University of Tsukuba, Japan
28/07-11/08- 2010 Lecture and laboratory in the field of Biomedical Engineering&
Environmental Science at Department of Biomedical
Engineering&, Environmental Science, National Tsing Hua
University.
28-31/08-2010 Visiting researcher at laboratory of Molecular Neurobiology,
Department of Biochemistry and Molecular Biology of the Schoolof Biology of the University of Barcelona, Spain to perform
experiments on the use of techniques of BRET (Bioluminescenceresonance energy transfer) and FRET (Fluorescence resonanceenergy transfer) to study protein interaction.
1-4/08-2010
Visiting researcher at the Institute of Molecular Cancer Researchof the University of Zurich, Switzerland.
25/10-20/11-2010 Lecture and laboratory in the field of Biomedical Engineering&
Environmental Science at Department of Biomedical
Engineering&, Environmental Science, National Tsing Hua
University.
19-26/10-2013 Visiting professor at Nagasaki Laboratory, Department ofMaterials Science, Graduate School of Pure and Applied Sciences,
University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan.
1/4- 30/6-2014 Visiting professor at Nagasaki Laboratory, Department ofMaterials Science, Graduate School of Pure and Applied Sciences,
University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan.
7-13/05/2018
IBRO Visiting Lecturer in IBRO Neuroscience School and invited speaker at
Neuroscience Society of Nepal Meeting
22-23/08/2018 Visiting professor at Lab Neutrition and Integrative Neurobiology (NetriNeuro)
INRA-Bordeaux University, France
24-30/09/2018 Visiting professor at College of Food Science and Engineering, Ocean
University of China
29/04-10/05/2019 Researcher exchange under Nagasaki Laboratory,
Department of Materials Science, Graduate School of Pure and Applied
Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan
12-26/10/2019 Researcher exchange under Nagasaki Laboratory,
Department of Materials Science, Graduate School of Pure and Applied
Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan
Current position
06/2011-05/2012 Research scientist in Graduate School of Pure andApplied Science of Tsukuba, University of Tsukuba, Japan
06/2012-09/2016 Lecturer at Department of Physiology, Faculty of Science, Prince ofSongkla University
10/2016-09/2017 Lecturer at College of Alternative Medicine, Chandrakasem Rajabhat
University
10/2017-present Research Officer (Sub 2 band 2) at Expert Centre of Innovative Health Food
(InnoFood), Thailand Institute of Scientific and Technological Research(TISTR)
Former position
2012-2014
Vice Chair Person of Department Graduate Study Committee
2013-2015
Adviser for Student Dormitory Committee (Hatyai campus)
2021-present Advisory level of Food Division (Sub Functional Food), Thai FDA
Teaching experiences- Physiology in Neuroscience topic for undergraduate student in all faculty of Health science,Prince of Songkla University, Thailand- Physiology in Cardiovascular system for undergraduate student in all faculty of Health science,Prince of Songkla University, Thailand- Physiology in Neuroscience topic for Graduate student in Physiology Program, Prince ofSongkla University, Thailand- Experimental animals of research in pharmacological testing topic for Graduate student in
Department of Fishery Product, Faculty of Fisheries, Kasetsart University, Thailand- Quality Assurance in Dietary supplement and Drug Manufacturing for Faculty of
Pharmaceutical Science, KhonKaen University, Thailand- Functional Food for School of Anti-Aging and Regenerative Medicine, Mae Fah Luang
University, Thailand
Research paper published
1. Pichaya Jumnongprakhon, Krittalak Pasakawee, Panida Banjongsinsiri, Nowwapan Donrung,
Supawadee Daodee, and Pennapa Chonpathompikunlert* . The effects of ethanolic extract ofOkra fruit, Abelmoschus Esculentus (L.) Moench on cellular senescence in aging neuron.
Songklanakarin Journal of Science and Technology. Vol. 43 No. 5 (September - October, 2021)
2. Wanwimol Klaypradit, Mantira Hawangjoo, Nujamee Ngasakul, Pennapa Chonpathompikunlert,
Maruj Limpawattana, Wanida Sukketsiri* Tuna blood inhibits lipopolysaccharide-induced
inflammatory mediators in RAW264.7 macrophages. Functional Foods in Health and Disease 2021;
11(4):201-212.
3. Jirapa Puntarut, Wipawadee Sianglum, Supita Tanasawet, Pennapa Chonpathompikunlert,
Wanida Sukketsiri. (2020). Anti-inflammatory effect of Tamarind seed coat extract against LPSinduced RAW264.7 Macrophages. Sains Malaysiana 49, 1303-1312.
4. Supita Tanasawet, Wanida Sukketsiri, Pennapa Chonpathompikunlert, Wanwimol Klaypradit,
Morakot Sroyraya, Pilaiwanwadee Hutamekalin. (2020) Apoptotic effect of astaxanthin from white
shrimp shells on lung cancer A549 cells. Tropical Lournal of Pharmaceutical Research. 19, 18351842.
5. Jinatta Jittiwat, Pennapa Chonpathompikunlert, Wanida Sukketsiri. (2020). Neuroprotective
effects of Apium graveolens against focal cerebral ischemia occur partly via antioxidant, antiinflammatory, and anti-apoptotic pathways. J Sci Food Agric. Doi 10.1002/jsfa.10846.
6. Jirakrit Saetang, Pennapa Chonpathompikunlert, Somporn Sretrirutchai, Niran Roongsawang,
Kanita Kayasut, Supayang Piyawan Voravuthikunchai, Wanida Sukketsiri, Varomyalin Tipmanee,
Surasak Sangkhathat. (2020) Anti-cancer effect of engineered recombinant interleukin 18. Advancesin clinical and experimental medicine. 29 (10).
7. Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee
Hutamekalin, Yukio Nagasaki (2020) Self-assembled polydopamine nanoparticles improvetreatment in Parkinson’s disease model mice and suppress dopamine-induced dyskinesia. Acta
Biomaterialia. 109, 220-228.
8. Takunrat Taksima, Pennapa Chonpathompikunlert*, Morakot Sroyraya, Pilaiwanwadee
Hutamekalin, Maruj Limpawattana, Wanwimol Klaypradit* (2019) Effects of Astaxanthin from
Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease. Marine
Drugs. 17, 628; doi:10.3390/md17110628
9. Jakkapong Muangsab, Peerada Prommeenate, Banthit Chetsawang, Pennapa
Chonpathompikunlert, Wanida Sukketsiri, Pilaiwanwadee Hutamekalin. (2019) Protective effectof valproic acid on MPP+-induced neurotoxicity in dopaminergic SH-SY5Y cells throughCdk5/p35/Erk signaling cascade. Tropical Journal of Pharmaceutical Research. 18(11):2255-2261.

10. Henna Hakimee, Pilaiwanwadee Hutamekalin, Supita Tanasawet, Pennapa Chonpathompikunlert,
Varomyalin Tipmanee, Wanida Sukketsiri. (2019) Metformin inhibit cervical cancer migration by
suppressing the FAK/Akt signaling pathway. Asian Pacific Journal of Cancer Prevention. 20 (12),3539-3545.
11. Udomlak Kongprasom, Wanida Sukketsiri, Pennapa Chonpathompikunlert, Morakot Sroyraya,
Somporn Sretrirutchai, Supita Tanasawet. (2019) Pseuderanthemum palatiferum (Nees) Radlk
extract induces apoptosis via reactive oxygen species-mediated mitochondria-dependent pathway in
A549 human lung cancer cells. Tropical Journal of Pharmaceutical Research. 18 (2): 287-294.
12. Takunrat Taksima, Maruj Limpawattana, Pennapa Chonpathompikunlert, Wanwimol Klaypradit.
(2018) Physicochemical and microbiological Qualities of mixed fruit juice beverage powder
incorporated with astaxanthin under different storage conditions. Thai Science and Technology
Journal. Doi:10.14456/tstj.2020.66
13. Chonpathompikunlert, P., Boonruamkaew, P., Sukketsiri, W., Hutamekalin, P., Sroyraya, M.
(2018). The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative
effect on MPTP-induced Parkinson-like symptoms in mice. BMC Complementary and Alternative
Medicine. 18:103. https://doi.org/10.1186/s12906-018-2166-0.
14. Nitita Piya-amornphan, Pennapa Chonpathompikunlert, Warangkana Radchumrong, Chalee
Sriprachan. (2017) The Elderly’s Bone Mass, Muscle Mass, and Clinical Dementia Rating in
Kiriwong Community, Nakhon Si Thammarat Province. Area Based Development Research Journal.
TRF. 9th from 6 Nov.-Dec. p. 56-66.
15. Phetcharat Boonruamkaew, Pennapa Chonpathompikunlert, Long Binh Vong, Sho Sakaue,
Yasushi Tomidokoro, Kazuhiro Ishii, Akira Tamaoka, Yukio Nagasaki. (2017) Chronic treatment
with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576
mouse model of Alzheimer’s disease. Scientific Reports 7, Article number 3785. DOI:
10.1038/s41598-017-03411-7.
16. Phetcharat Boonruamkaew, Wanida Sukketsiri, Pharkphoom Panichayupakaranant, Wijittra
Kaewnam, Supita Tanasawet, Varomyalin Tipmanee, Pilaiwanwadee Hutamekalin, Pennapa
Chonpathompikunlert. (2017) Apium graveolens extract influences mood and cognition in healthy
mice. J Nat Med. DOI 10.1007/s11418-017-1077-6.
17. Wongtawatchai, T., Sarsutham, K., Sukketsiri, W., Tipmanee, V., Chonpathompikunlert, P.
(2016) Anti-stress effects of Apium graveolens on rats subjected to immobilization. International
Food Research Journal 24: 1490-1499.

18. Payanglee K, Chonpathompikunlert P, Panityakul T, Radenahmad N. (2016) Beneficial effects ofyoung coconut juice on preserving neuronal cell density, lipid, renal and liver profiles inovariectomized rats. A preliminary study. Songklanakarin Journal of Science and Technology,(article in press).
19. Tanasawet S, Boonruamkaew P, Sukketsiri W, Chonpathompikunlert P. (2017) Anxiolytic andfree radical scavenging potential of Apium Graveolens in mice. Asian Pac J Trop Biomed. 7(1):2026.
20. Wanida Sukketsiri, Pennapa Chonpathompikunlert, Supita Tanasawet, Nutjanat Choosri,
Tulaporn Wongtawatchai. (2016) Effects of Apium graveolens Extract on the Oxidative Stress in theLiver of Adjuvant-Induced Arthritic Rats. Prev.Nutr.Food Sci. 21(2):79-84.
21. Nutjanat Choosri, Supita Tanasawet, Pennapa Chonpathompikunlert, Wanida Sukketsiri. (2016)
Apium Graveolens Extract attenuates adjuvant induced arthritis by reducing oxidative stress. Journalof Food Biochemistry. Doi: 10.1111/jfbc.12276.
22. Kuedo Z, Sangsuriyawong A, Klaypradit W, Tipmanee V, Chonpathompikunlert P. (2016) Effects
of astaxanthin from Litopenaeus Vannamei on carrageenan-induced edema and pain behavior inmice. Molecules, 21, 382; doi:10.3390/molecules21030382
23. Boonruamkaew P, Chonpathompikunlert P, Nagasaki Y. (2016) Redox nanoparticle therapeutics
for acetaminophen-induced hepatotoxicity in mice. Oxidative Medicine and Cellular Longevity.
Volume 2016, Article ID 4984597, 10 pages. http://dx.doi.org/10.1155/2016/4984597
24. Chonpathompikunlert P, Yoshitomi T, Vong LB, Imaizumi N, Ozaki Y, Nagasaki Y. 2015.
Recovery of cognitive dysfunction via oral administered redox-polymer nanotherapeutics in SAMP8
mice. PLOS ONE, accepted.
25. Yoshitomi T, Sha S, Vong LB, Chonpathompikunlert P, Matsui H, Nagasaki Y. (2014).
Indomethacin-loaded redox nanoparticles improve oral bioavailability of indomethacin and suppress
its small intestinal inflammation. Therapeutic Delivery, 5(1): 29-38.
26. Pua ML, Yoshitomi T, Chonpathompikunlert P, Hirayama A, Nagasaki Y. (2013). Redox-active
injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive
treatment of local inflammation. Journal of Controlled Release, 172(3): 914-920.
27. Sha S, Vong BL, Chonpathompikunlert P, Yoshitomi T, Matsui H, Nagasaki Y. (2013).
Suppression of NSAID-induced Small Intestinal Inflammation by Orally Administered Redox
Nanoparticles. Biomaterial, 34: 8393-8400.

28. Chonpathompikunlert P, Fan CH, Ozaki Y, Yoshitomi T, Yeh CK, Nagasaki Y. (2012). Redox
nanoparticle treatment protects against neurological deficit in focused ultrasound-induced
intracerebral hemorrhage. Nanomedicine, 7(7):1029-43.
29. Chonpathompikunlert P, Yoshitomi T, Han J, Isoda H, Nagasaki Y. (2011). The use of nitroxide
radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells
from Aβ-induced oxidative stress. Biomaterial, 32: 8605-8612.
30. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2011). Chemical
nanotherapy: nitroxyl radical-containing nanoparticle protects neuroblastoma SH-SY5Y cells fromAβ-induced oxidative stress. Ther Deliv, 2(5): 585-597.
31. Chonpathompikunlert P, Han J, Toh K, Isoda H, Nagasaki Y. (2011). TEMPOL protects humanneuroblastoma SH-SY5Y cells against β-amyloid-induced cell toxicity. Eur J Pharmacol, 650: 544549.
32. Priprem A, Chonpathompikunlert P, Sutthiparinyanont S, Wattanathorn J. (2011). Antidepressantand cognitive activities of intranasal piperine-encapsulated liposomes. Advances in Bioscience andBiotechnology, 2(2): 107-115.
33. Chonpathompikunlert P, Wattanathorn J, Muchimapura S. (2010). Piperine, the main alkaloid ofThai black pepper, protects against neurodegeneration and cognitive impairment in animal model ofcognitive deficit like condition of Alzheimer’s disease. Food Chem Toxicol, 48(3):798-802.
34. Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O. (2008).
Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol, 46(9):3106-3110.
Conference/Proceeding
1. Ratchaneekorn Reudhabibadh, Nidanut Champoochana, Nipaporn Konthapakdee, Pennapa
Chonpathompikunlert, Pilaiwanwadee Hutamekalin. Effects of the Flavonoid Luteolin on
Oxidative Stress in Parkinson’s Disease Model. The 31st Annual Meeting of the Thai Society for
Biotechnology and International Conference (TSB2019) DOI: 10.14455/TSB.res.2019.24
2. Chonpathompikunlert Pennapa. Role of research and development to functional food andingredient products in Thailand. International and Food Conference (ICPF) 2018. Shizuoka, Japan(speaker)3. Chonpathompikunlert Pennapa. Therapeutic application of Apium graveolens extracts forneurodegenerative disease. Third Annual Meeting of Neuroscience Society of Nepal (NSN). May
12-13, 2018. Nepal. (speaker)
4. Chonpathompikunlert Pennapa. Thailand country reports: Research, Trends and Market
Opportunity on Functional Foods for NCDs. ASEAN Biodiversity on Functional Foods for Noncommunicable Diseases. ASEAN NEXT 2018. March 20-22, 2018. Bangkok. (speaker)
5. Chonpathompikunlert Pennapa, Boonruamkaew Phetcharat, Sukketsiri Wanida, Wongtawatchai
Tulaporn, Tanasawet Supita. The effect of A. graveolens on cognitive enhancing property and lipid
peroxidation in hippocampus area of healthy adult mice. 10th FENS Forum of Neuroscience. July 29, 2016. Copenhagen, Denmark. (Poster presentation)
6. Boonruamkaew Phetcharat, Sukketsiri Wanida, Sroyraya Morakot, Sobhon Prasert,
Chonpathompikunlert Pennapa*. The neuroprotective effect of Apium Graveolens L. on MPTPinduced C57BL/6 mice model. 10th FENS Forum of Neuroscience. July 2-9, 2016. Copenhagen,Denmark. (Poster presentation by Phetcharat)
7. Tanasawet Supita, Boonruamkaew Phetcharat, Sukketsiri Wanida, Wongtawatchai Tulaporn,
Chonpathompikunlert Pennapa*. Anxiolytic properties of methanolic extract of Apium
graveolens and its possible mechanism of action. 10th FENS Forum of Neuroscience. July 2-9, 2016.
Copenhagen, Denmark. (Poster presentation by Supita)
8. Wongtawatchai Tulaporn, Sarsutham Kidakan, Sukketsiri Wanida, Tipmanee Varomyalin,
Chonpathompikunlert Pennapa*. Anti-stress effects of Apium graveolen in immobilization rat.
10th FENS Forum of Neuroscience. July 2-9, 2016. Copenhagen, Denmark. (Poster presentation by
Tulaporn)
9. Kuedoa Z, Nuanplaba S, Klaypraditb W, Chonpathompikunlert P*. Effects of astaxanthin from
Lipopenaeus vannamei on carrageenan-induced paw edema in mice. The 6th International
Conference on Natural Products for Health and Beauty (NATPRO6), 21st to 23rd January, 2016 atPullman Raja Orchid Hotel, Khon Kaen, Thailand. (Poster presentation by Kuedoa Z)
10. Boonruamkaew P, Sukketsiri W, Tanasawet S, Chonpathompikunlert P*. Ameliorative Effect ofApium graveolens L. on Scopolamine-Induced Amnesia Mice. Isan Journal of Pharmaceutical
Sciences. Volume 10 (Supplement), January 2015 page 82-93. At the 1st International Conference on
Herbal and Traditional Medicine (HTM 2015), Pullman Khon Kaen Raja Orchid Hotel, Khon Kaen,
Thailand. January 28-30, 2015.

11. Boonruamkaew, P. Sukketsiri, W. Chonpathompikulert, P*. (2014). The Potential Effect of Apium
graveolens L. on Scopolamine-induced Amnesia Mice. The Neuroscience Symposium of Brain
Institute Monash Sunway (BRIMS) and NeuroMalaysia Society, 27th-28th September, 2014. (Poster
presentation by Boonruamkaew P)
12. Nutjanat C., Tanasawet S., Chonpathompikunlert P., Sukketsiri W., 2014. Anti-arthritic activity ofmethanolic extract of Apium graveolen in Complete Freund’s Adjuvant induced arthritis in rats.
Proceeding of the 36th Congress on Pharmacology of Thailand, 84-87. (Poster presentation by
Nutjanat C)
13. Boonruamkaew, P. Sukketsiri, W. Hiranphan, P. Radchunrong, W. Chonphathompikunlert, P.*(2013). Apium graveolens L. Crude Extract Enhances Cognitive Function in Mice. The international
conference and 31st Annual Meeting of the Indian Academy of Neuroscience (IAN) Oct 25-27,
2013. (Oral presentation by Boonruamkaew P)
14. Chonpathompikunlert P, Yoshitomi T, Nagasaki Y. (2012). Effects of Nitroxide radicalcontaining nanoparticles suppress inflammation-induced edema and pain behavior in mice. MANAInternational Symposium, Epochal Tsukuba, Japan. (oral presentation)
15. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2011). Nitroxyl
radical-containing nanoparticle protects neuroblastoma SH-SY5Y cells from Aβ-induced oxidative
stress. TJIA 2011 Thailand Japan International Academic Conference. Tokyo, Japan. (oralpresentation)
16. Chonpathompikunlert P, Fan CH, Ozaki Y, Yoshitomi T, Yeh CK, Nagasaki Y.(2011).
Antioxidant-Nanocarier Attenuates intracerebral hemorrhage induced by Focused Ultrasound. 8th
IBRO World Congress of Neuroscience in Florence, Italy. (poster presentation)
17. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2011). Combination
Nanotherapy - Drug Delivery by Antioxidative Nanocarrier. MANA International Symposium,
Epochal Tsukuba, Japan, p. 131. (oral presentation)
18. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2011). Antioxidant
effect of Radical-Containing Nanoparticle (RNP) combination piperine against Alzheimer’s amyloid
beta-peptide (1-42)-induced oxidative stress in SH-SY5Y cells. International Conference on
Biomaterials Science (ICBS), Tsukuba, Japan. (poster presentation)
19. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2011). Combination
Nanotherapy for Drug Delivery by Antioxidative Nanocarrier. International Symposium on Free

Radical Research: Contribution to Medicine. Hyatt Regency Kyoto, Japan, p. 124. (poster
presentation)
20. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2010). Comparison of
the effects of TEMPO, Radical containing Nanoparticle and Radical containing Nanoparticle
combination Piperine on Aβ Amyloid Toxicity. The 3rd International NanoBio Conference, ETH
Zurich, Switzerland. (Published online in a special supplement of the Cells and Materials (eCM)
Journal). (poster presentation)
21. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y. (2010).
Neuroprotective effect of Radical-containing Nanoparticle (RNP) against Alzheimer’s amyloid betapeptide (1-42)-induced oxidative stress in SH-SY5Y cells. The 63th National conference of Society
for free radical research, Yokohama, Japan, p. 74. (oral presentation)
22. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A. (2009). Nasal
administration of liposome encapsulated piperine attenuates the memory deficit and neuronal loss inAlzheimer’s model induced by AF64A. The 27th Hong Kong Society of Neurosciences Annual
Meeting, The University of Science and Technology, Hong Kong, p. 170-171. (poster presentation)
23. Pennapa Chonpathompikunlert, Jintanaporn Wattanathorn, Supaporn
Muchimapura,
Aroonsri Priprem. (2008) Effect of piperine on neuroprotective effect against Alzheimer’s disease.
The 3rd FAONS. Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok,Thailand(poster presentation)
24. Chonpathompikunlert P, Wattanathorn J, Muchimapura S. (2008). Effect of piperine on cognitionand oxidative stress in animal model of Alzheimer’s disease. The 3rd Sino-Thai International
Conference on Traditional Medicine and Natural Health Products. Guangxi Traditional Chinese
Medical University, China, p. 358-364. (oral presentation)
25. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A, Tankumnerdthai O. (2008).
Piperine Reduces Hippocampal Neuronal Loss in Animal Model of Alzheimer’s Disease. First
National Neuroscience Conference. Science Park Convention Center, Thailand, p. 78. (poster
presentation)
26. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A. (2007). Piperine, the mainalkaloid of piper nigrum, enhances cognitive function in rats. The 2nd Sino-Thai International
Conference on Traditional Medicine and Natural Products. Kosa Hotel, Khon Kaen, Thailand, p.
420-425. (poster presentation)

27. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A. (2007). Nasal
administration of liposome encapsulated piperine enhances cognitive function in young adult rats.
The 3rd International Conference on Polyphenols and Health. Kyoto, Japan, p. 230. (poster
presentation)
28. Chonpathompikunlert P, Wattanathorn J, Priprem A. (2007). Study of the Effect of piperine on
Cognitive Enhancing Property and Lipid Peroxidation in Hippocampus Area of Healthy Adult Rats.
Asian Association of Schools of Pharmacy (AASP), Makati City, Philippines, p. 94. (poster
presentation)
29. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A, Tong-un T. (2006).
Neuropharmacological profile of piperine. The 4th Congress of Federation of Asian-Oceanian
Neuroscience Societies, Hong Kong, p. 128-129. (poster presentation)
30. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Banchonglikitkul C, Suntorntanasas T,
Singhara S. (2006). Screening the effect of KKU1 on the central nervous system. CollegiumInternationale Neuro-Psychopharmacologicum (CINP) Asia Pacific Regional Meeting NeuroPsychopharmacology: Challenging for Better Health, Pataya, Thailand, p. 115. (poster presentation)
31.
Research report or grantNo.
1(closed)
Project
LeaderYear
Grant Source(1 year) PSU-for new Staff 2012
Dec.
2012Dec.
2013

Research Title
BudgetEffect of Apium 50,000 THB
graveolens Linn on
centralnervoussystem (CNS)

2(closed)Coresearcher

2 years
The
Agricultural( 2013- Research Development
2015)
Agency(Public
Organization)

Wanida Sukketsiri, Ph.D
Supita Tanasawet, Ph.D
Tulaporn Wongtawatchai,Ph.D.

3(closed)
Project
Leader

1 year(20132014)

Wanida Sukketsiri, Ph.D.
Tulaporn Wongtawatchai,
Ph.D.

Topical preparation of 344,000 + 663,000
tamarind seed coat on =1,007,000 THB
second degree burnwound healing indiabetic and nondiabetic rats
BRAND’Sbrain The potential effect of 350,000 THB
Research Centre 2556
Apium Graveolens L.
to protect against
neurodegeneration in
Parkinson-like
symptoms induced by
MPTP modelColleague-4 (closed)
Project
Leader

2 year(20142016)5(closed)Coresearcher

2 years(20152017)6(close)Coresearcher

2 years(20152017)7(closed)
Project
Leader

1 year(20162017)8(closed)Coresearcher

1 years(20172018)9.
(on going)

5 years(2017-

Invention of Prince of Effect of Apium 200,000 THB
Songkla University-2014 Graveolens L. on
anxietyanddepression induced byimmobilized stressand MPTP-induced
Parkinson’s disease inanimal model
The Thailand Research Potential evaluation 600,000 THB
of lipid and free acidFund-2015

Wanida Sukketsiri, Ph.D.
Tulaporn Wongtawatchai,
Ph.D.

Medicine Faculty-PSU. Anti-cancer
2015
immunotherapeutic
effect evaluation ofrecombinantengineered
interleukin-18 invivo
Invention of Prince of Anti-inflammatory
Songkla University-2016 effects of astaxanthin
andastaxanthinliposome from white
shrimp shell on
carrageenan-induced
paw edema in mice
National
Research DevelopmentofCouncil of Thailand 2017 powdered beverage
from astaxanthin andits effects
onprevention of induced
Alzheimer’s disease intested animals
TISTR-National Research ResearchandCouncil of Thailand
Development
on754,500 THB

Assoc. Prof. Dr. Surasak
Sangkhathat(MD. PhD.) and Team

200,000 THB

Supita Tanasawet, Ph.D.

550,000 THB

Assist Prof. Wanwimol
Klaypradit

77,402,600 THB

Mrs. Pattra Ahmadi
Pirshahid and TISTR

Morakot Sroyraya, Ph.D.

alterations as abiomarker in MPTP
mouse model ofParkinson’s diseaseusing matrix-assisted
laser
desorption/ionization
imagingmass
spectrometry(MALDI-IMS)

Coresearcher

2021)

10.
(on going)
Coresearcher

4 years(20182021)

11.
(on going)
Project
Leader

4 years(20182021)

12.
(on going)
Coresearcher

4 years(20182021)

13.
(on going)
Project
advisor2 year(20182019)14.
(on going)Co-

3 year(20192021)

Functional IngredientsFor
The
Elderly with NonCommunicable
Diseases (NCDs)
TISTR-National Research ResearchandCouncil of Thailand
Developmenton
Innovative Functional
Product from
Probiotics for Brain
Booster for Pre-Aging
Population.
TISTR-National Research ResearchandCouncil of Thailand
developmentof
naturally active -foodingredients from fruitand vegetable to apply
in functional foodproducts
forcontrolling
hypertension
andhyperlipidemia in preaging and ageing
society.
TISTR-National Research ResearchandCouncil of Thailand
Developmentofprobiotic products forthe people with
Irritable
Bowel
Syndrome
Walailak University
The protective effectofdopaminergic
neuronsof
Astaxanthin extractfrom white shrimp
shell on C57BL/6
mice model of MPTPinduced Parkinsonlike symptom
The Agricultural
Anti-tumor immunity
Research Development
promoting effect ofAgency (Public
Piperine – Free Piper

team

4,752,000 THB

Panida Banjongsinsiri,
PhD. And TISTR team

3,730,000 THB

InnoFood Team at TISTR

4,000,000 THB

Dr. Supaporn LTISTR
Team

400,000 THB

Dr. Phetcharat
Boonruamkaew and team

1 M.THB

Assoc. Prof. Dr. Surasak
Sangkhathat(MD. PhD.) and Teamresearcher
15.
(on going)
Coresearcher
16.
(on going)
Coresearcher

3 year(20192021)

1 year20202021

Organization) 2019
National ResearchCouncil of Thailand 2019

Thai Goverment

nigrum Extract
Developmentof 500000 THB
Dietary Supplementfrom Tuna-blood andtoxicity test in animal
model
Probiotic for Food 154 M.THB
pilot plant

Assist Prof. Dr.
Wanwimol Klaypradit
Morakot Sroyraya, Ph.D.
Assist Prof. Dr. Wanida
Sukketsiri
Team Probiotic TISTR

Patents
1. Title: composition containing low-molecular antioxidant and high-molecular formed, cyclic nitroxide
radical compound
Document type and number: Japanese patent JP 2011184429
Name: Nagasaki Yukio, Matsui Yasushi, Yoshitomi Toru, Ozaki Yuki, Chonpathompikunlert Pennapa,
Isoda Hiroko, Han Junkyo
Publication Date: September 22, 2011
2. Title: Triblock copolymer and use thereof
Publication No. WO/2013/111801 was published on Aug. 1.
Name: Yukio Nagasaki, Min Ley Pua, Pennapa Chonpathompikunlert and Toru Yoshitomi.
Publication Date: August 1, 2013
Book Chapter
1. Book: The Nutritional Composition and Antioxidant Properties of Fruits and Vegetables
Title: Nutritional composition, health benefits and antioxidant properties of Chinese Celery.
ELSEVIER, published.
Journal Reviewers
1. Bulletin of the chemical society of japan
2. International Neuropsychiatric Disease Journal
3. Neurochemistry International
4. Biomaterial (ELSEVIER)
5. Microscopy Research and Technique (Wiley online Library)6. Trop J Pharm Res
7. Journal of Food Biochemistry
RESEARCH EXPERIENCES
Scavenging enzyme action pathways (both in vitro and in vivo technique), Cognitive deficit
condition (Behavioral testing in animal), Neurodegenerative disease in animal model, free radical relateddisease, Neuropharmacology, Nanotechnology for drug delivery system (nanoparticle preparation), Evaluate
neuropharmacological activities of natural product compound (both in vitro and in vivo model), testing
efficacy of Functional Food or ingredientRESEARCH OF INTEREST
Overall research goal focuses on the role of nanotechnology for drug/Food ingredient delivery totreatment various pathological conditions that related with free radical pathway. Specifically, we areinterested in(1) Neurodegenerative disease such as AD, PD, stress condition in animal model(2) Brain tumor or cancer in animal model(3) Inflammatory disease such as OA, RA and pain condition in animal model(4) Neuromarketing using Electroencephalogram (EEG) in human-Head of This Lab at TISTR(5) Genotoxicity testing follow OECD guideline (Comet assay)-Head of This Lab at TISTRSCIENTIFIC PRESENTATION AWARDS
1. Attendance in the 11th International Brain Research Organization (IBRO) Associate School of
Neuroscience in Kuala Lumpur, Malaysia, 2007
2. Attendance in Tsukuba Research Center for Interdisciplinary Materials Science (TIMS) Universityof Tsukuba, Japan for two month about nanoparticle of drug delivery system, 2008
3. The Outstanding Oral Presentation Award from The 3rd Sino-Thai International Conference on
Traditional Medicine and Natural Health Products, 31/10/2008
4. Attendance in the 7th IBRO school of neuroscience, Hong Kong, 2009
5. Travel grant from The 3rd International NanoBio Conference, ETH, Zurich, Switzerland (23-27
August, 2010)
6. Travel grant from IBRO for attendance in the 8th IBRO World Congress of Neuroscience, Florence,
Italy (14-18 July,2011)

Young Research Awards from BRAND’S Brain Research Centre 2013 (6 Nov. 2013)
8. Special Lecture for 2nd IBRO Neuroscience School Nepal 2018 and Speaker at 3rd Annual
Conference of Neuroscience Society of Nepal 2018 (8-13 May 2018), Kathmandu, Nepal
7.