June 17, 2019
SymBio Pharmaceuticals Limited
Fuminori Yoshida
Representative Director,President and Chief Executive Officer
Completion, Monthly Exercise Status and Large Volume Exercise of the 46th Stock Acquisition Rights(with Exercise Price Revision Clauses) Issued by way of Third Party Allotment
TOKYO, Japan, June 17, 2019—SymBio Pharmaceuticals Limited (JASDAQ: 4582) announces the monthly exercise
status and the large volume exercise of the 46th Stock Acquisition Rights issued during the period from June 14, 2019 to June17, 2019, and that the exercise of all 46th stock acquisition rights issued and allotted to EVO FUND on April 25, 2018, arecompleted as of today.
I. The Large Volume Exercise(1)(2)

Name of the stock acquisition

SymBio Pharmaceuticals Limited 46th Stock Acquisition Rightsrights
Number of issued shares from theprevious disclosure
Number of stock acquisition rights(3)

being exercised from the previous
disclosure and the ratio to the

1,866,000 Shares
1,866,000 Units（Ratio to the total number of stock acquisition rights issued 15,000,000
units ：12.44％）

entire issue
Number of unexercised stock(4)

acquisition rights as of the

1,866,000 Units

previous disclosure
Number of remaining(5)

unexcercised stock acquisition

0 Unitsrights as of today(6) Exercise status from the previous disclosure
Number of delivered shares
Exercise Date

New Shares (Shares)

Treasury Shares

Number of stock
Exercise Price (¥)

Transferred (Shares)

acquisition rights
being excercised(Units)

June 14 (Fri.)

－－154

－

June 17 (Mon.)

1,866,000－

154

1,866,000※Number of issued shares at the end of the previous month：91,784,724 shares〔of which 75 shares are treasury shares〕

1II. Monthly Exercise Status(1)(2)

Name of the stock acquisition

SymBio Pharmaceuticals Limited 46th Stock Acquisition Rights

rightsNumber of issued shares from the

5,666,000 Shares

beginning of the month
Number of stock acquisition rights(3)

being exercised from the

5,666,000 Units(Ratio to the total number of stock acquisition rights issued 15,000,000

beginning of the month and theunits ：37.77%）

ratio to the entire issue
Number of unexercised stock(4)

acquisition rights as of the5,666,000 Units

beginning of the month
Number of remaining(5)

unexcercised stock acquisition

0 Unitsrights as of today(6) Exercise status from the beginning of the month
Number of delivered shares
Exercise Date

Treasury Shares

New Shares (Shares)

Number of stock
Exercise Price (¥)

Transferred (Shares)

acquisition rights
being excercised(Units)

June 3 (Mon.)

－－165

－

June 4 (Tue.)

500,000－

162

500,000－

－

162

－

June 11 (Tue.)

1,800,000－

154

1,800,000

June 12 (Wed.)

500,000－

154

500,000

June 13 (Thu.)

1,000,000－

154

1,000,000

June 14 (Fri.)

－－

154

－

June 17 (Mon.)

1,866,000－

154

1,866,000

June 5 (Wed.) toJune 10 (Mon.)※Number of issued shares at the end of the previous month：91,784,724 shares〔of which 75 shares are treasury shares〕(7) Status concerning restriction on exercise (Status concerning compliance with exercise restrictions under Article 434 ofthe Listing Regulations)①

Total number of shares②

Number of listed shares at thedelivered upon the exercise oftime of the payment for theall series of stock acquisition

issuance③

Exercise ratio on exercise
limit(①/②)

rights5,666,000 Shares

57,840,724Shares

9.80％

For further details regarding this issuance, please refer to “Notice of the Issuance of the 45th through 47th StockAcquisition Rights with Exercise Price Revision Clauses (Committed Issue Program) and Conclusion of an Unsecured
Loan Facility Agreement” published on April 9, 2018.

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