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Phenolphthalein,JUNSEI CHEMICAL CO., LTD.,63035jis_J_E1-3,21/Dec/2023
Date of issue for the 1st edition : 10/Dec/2015
Date of revision : 21/Dec/2023

Safety Data Sheet

Section 1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Phenolphthalein
Reference number(SDS):63035jis_J_E1-3
Product type：
Reagent
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance DepartmentTelephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

Section 2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
HEALTH HAZARDS
Germ cell mutagenicity: Category 2
Carcinogenicity: Category 2
Reproductive toxicity: Category 1BSpecific target organ toxicity - repeated exposure: Category 1 (intestine)(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H341-Suspected of causing genetic defects
H351-Suspected of causing cancer
H360-May damage fertility or the unborn childH372-Causes damage to organs through prolonged or repeated exposure
PRECAUTIONARY STATEMENT
Prevention
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fume/gas/mist/vapors/spray.
Wash contaminated parts thoroughly after handling.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
Get medical advice/attention if you feel unwell.
IF exposed or concerned: Get medical advice/attention.
Storage
Store locked up.

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Disposal
Dispose of contents/container in accordance with local/national regulation.

Section 3. Composition/information on ingredients
Mixture/Substance selection:SubstanceCommon name, synonyms: 3,3-Bis-(4-hydroxyphenyl)-1-(3H)-isobenzofuranon
Ingredient name:Phenolphthalein
Content (%):98.0 <Chemical formula:C20H14O4
Chemicals No, Japan:9-1152
CAS No.:77-09-8
MW:318.33
ECNO:201-004-7
Note : The figures shown above are not the specifications of the product.
Components contributing to the hazard
Carcinogenic (Article 57a) in REACH SVHC candidate list
Phenolphthalein

Section 4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation or rash occurs: Get medical advice/attention.
IF IN EYESRinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayedSpecific information on symptom and effect are unknown.
Indication of any immediate medical attention and special treatment needed
Information on indication of any immediate medical attention and special treatment needed
is not available.

Section 5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use water mist, foam, dry powder, CO2 to extinguish.
Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.

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Runoff from fire control or dilution water may cause pollution.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with a full facepiece operated
in the positive pressure mode.

Section 6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Ventilate area until material pick up is complete.
Wear proper protective equipment.
Environmental precautions
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Sweep up, place in a bag and hold for waste disposal.
Preventive measures for secondary accident
Collect spillage.

Section 7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong oxidizing agents should not be mixed with the chemicals.
Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
StorageConditions for safe storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.

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Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

Section 8. Exposure controls/personal protection
Control parametersControl value in MHLW is not available.
Adopted value
Adopted value in JSOH is not available.
Adopted value in ACGIH is not available.
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Recommended respiratory protection：Dust mask(e.g. JIS T8151)
Hand protection
Wear protective gloves.
Inspect before use and replace worn or damaged gloves.
Contact the glove manufacturer for specific advice on glove selection and breakthroughtimes for your use conditions.
Chemical-resistant, impervious gloves complying with an approved standard (e.g. JIS T8116)
should be used.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.
Personal protective equipment for the body and skin should be selected based on the task
being performed and the risks involved.

Section 9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Crystals or crystalline powder
Color: White or pale yellow
Odor: Odorless
Odor threshold data is not available.
Melting point/Freezing point: 263.7℃
Boiling point or initial boiling point data is not available.
Boiling range data is not available.
Flammability (gases, liquids and solids) data is not available.
Lower and upper explosion limit/flammability limit data is not available.
Flash point data is not available.
Auto-ignition temperature data is not available.
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity data is not available.
Kinematic viscosity data is not available.

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Phenolphthalein,JUNSEI CHEMICAL CO., LTD.,63035jis_J_E1-3,21/Dec/2023
Solubility:
Solubility in water: Slightly soluble0.4g/liter(room temperature)
Solubility in solvent: Very soluble in ethanol(99.5); soluble in ethyl ether.
n-Octanol/water partition coefficient data is not available.
Vapor pressure data is not available.
Vapor density data is not available.
Density and/or relative density: 1.277(32℃)
Relative vapor density (Air=1) data is not available.
Relative density of the Vapor/air - mixture at 20℃ (Air = 1) data is not available.
Particle characteristics data is not available.
Other information
Critical temperature data is not available.
Evaporation rate data is not available.
VOC data is not available.
Other information is not available.

Section 10. Stability and Reactivity
Reactivity
Runaway polymerization will not occur.
Chemical stability
Stable under normal storage/handling conditions.
Possibility of hazardous reactions
Possibility of hazardous reactions data is not available.
Conditions to avoid
Contact with incompatible materials.
Open flames. Heating.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Carbon oxides

Section 11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Acute toxicity (Dermal)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Acute toxicity (Inhalation)[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

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Irritant properties
Skin corrosion/irritation[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Serious eye damage/irritation[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Sensitization
Respiratory sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Skin sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Germ cell mutagenicity[Product]Category 2, Suspected of causing genetic defects[Data for components of the product][GHS Cat. Japan, base data]
cat. 2; NTP DB, 2008
Carcinogenicity[Product]Category 2, Suspected of causing cancer[Data for components of the product][GHS Cat. Japan, base data]
cat.2; IARC Gr, 2B (IARC 76, 2000 et al.)[IARC]
Group 2B : Possibly carcinogenic to humans[NTP]
RAHC : Reasonably Anticipated to be Human Carcinogens[EU]
Category 1B; Substances presumed to have carcinogenic potential for humans
Reproductive toxicity[Product]Category 1B, May damage fertility or the unborn child[Data for components of the product][GHS Cat. Japan, base data]
cat. 1B; mouse : IARC 76, 2000
Specific target organ toxicity (STOT)
STOT-single exposure[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

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STOT-repeated exposure[Product]Category 1, Causes damage to organs through prolonged or repeated exposure[Data for components of the product][cat.1][GHS Cat. Japan, base data]intestine (IARC 76, 2000)
Aspiration hazard[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.

Section 12. Ecological Information
Toxicity
Aquatic toxicity[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
Toxicity data is not available.
Persistence and degradability
Persistence and degradability data is not available.
Bioaccumulative potential
Bioaccumulative potential data is not available.
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

Section 13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,including the disposal of any contaminated packaging
Waste treatment methods
Dispose of contents/container in accordance with local/national regulation.

Section 14. Transport Information
UN No., UN CLASS
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulated
IMDG Code (International Maritime Dangerous Goods Regulations)
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulatedIATA (Dangerous Goods Regulations)
UN Number or ID Number : Not regulated
UN Proper Shipping Name : Not regulated
Class or division (Transport hazard class) : Not regulated
Packing group : Not regulated

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Environmental hazards
Marine pollutants (yes/no) : noTransport in bulk according to Annex II of MARPOL 73/78 and the IBC CodeNot applicable to Transport in bulk according to Annex II of MARPOL and the IBC CodeMARPOL Annex V - HME (Harmful to the Marine Environment)Reproductive toxicity: cat.1, 1A, 1B
Phenolphthalein
Specific target organ toxicity - repeated exposure: cat.1
Phenolphthalein

Section 15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
List of substances subject to authorisation (REACH, Annex XIV)/SVHC - candidate list
Carcinogenic (Article 57a)
Phenolphthalein
U.S. Toxic Substances Control Act (TSCA) Inventory
Chemicals listed in TSCA Inventory
77-09-8
All components are listed or exempted.
Superfund Amendments and Reauthorizations Act (SARA), Title III
SARA 313 (TRI)
Phenolphthalein
Other regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by yourresponsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local
regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informedby supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

Section 16. Other information
GHS classification and labellingH341-Germ cell mutagenicity, Category 2: H341 Suspected of causing genetic defects
H351-Carcinogenicity, Category 2: H351 Suspected of causing cancer
H360-Reproductive toxicity, Category 1B H360 May damage fertility or the unborn childH372-STOT - Repeated exposure, Category 1: H372 Causes damage to organs through prolonged
or repeated exposure
References and sources for data
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 22nd edit., 2021 UN
IMDG Code, 2020 Edition (Incorporating Amendment 40-20)
IATA Dangerous Goods Regulations (64th Edition) 2023
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2023 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 2019

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2022 Recommendation on TLVs (JSOH)
Notification No. 0111-1 (January 11, 2022), Chemical Hazards Control Division, Industrial
Safety and Health Department, Labour Standards Bureau, MHLW in Japan
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.25 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020, METI)
Abbreviations and acronyms
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)
JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of thisSafety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2022).