Create A World Full of Healthy Newborns

1spiker’s Alert-Monitor leads earlier
medical intervention by midwives
Quick Care !

Our Team
22 specialists from 6 countries !
AI engineers, analysts, software, hardware, Doctors and Midwives

3

Shortage of medical personnel
In African nations, patients far exceed the number of doctors andnurses available
Currently, countries are experiencing a dire shortage of medical
personnel who can monitor and properly care for a fetus’s well-being
African nations

SDG targetsJapan

1.3 medical

4.5 medical

13.7 medical

personnel/1,000 people

personnel/1,000 people

personnel/1,000 people

0.3 doctors/1,000

1.3 doctors/1,000

2.4 doctors/1,000people

peoplepeople0.9 nurses/1,000

3.2 nurses/1,000

11.3 nurses/1,000

peoplepeoplepeopleSource: WHO AFRO Health Workforce Observatory Database OECD Health Data (2019)4

Difficulty in Interpreting Live Patient Data
Properly understanding data requires medical
knowledge and many years of education
Developing nations face a shortage of medical personnel
possessing such expertise, and Pregnancy cannot use athome in Developed nations
In Japan, patient situation isassessed and classified into fivelevels:Level１：Active surveillance
Level２：Active surveillance＆Notice to Doctor
Level３：Doctor brought in + Prep. of OR
Level４：Transfer to operation room
Level５：Emergency caesarian section
Source: Japanese Society of Obstetrics and Gynecology
5

A Disappointing Reality

97.8% of perinatal

deaths* occur in developing
countries, of which African
nations are most severely
affected*the total number of fetal andneonatal deaths from 22 weeks
gestation to 7 days postpartum

Source: WHO(2016)

6

Behind the Reality
85.2% of pregnancy woman in developing countries
cannot use the medical device for delivery
CTG (Cardiotocogram): a medical device used to determine fetal well-being, by measuring fetal
heartbeat and uterine contraction
Period of usage• Prenatal care checkups（Two to three times, minimum of 40
minutes per measurement）• From beginning of contractions to timeof birth
Source: GEHP

7

Product - Plug-in AI software
spiker’s Alert-Monitor
leads earlier medical intervention by midwives

8

Product - Plug-in Alert Monitor
Manufactured by spiker
Obstetric
Monitoring Device

Communication Softwith spiker Edge AIRedboxCTG Data Analysis
AI Software

Transmitting Data ofFetal Heartbeatsand Uterine
Contractions

The alert notifies when
medical intervention isnecessary!

(CTG)

Cable

Acquisition of FetalHeartbeats and Uterine
Contractions

9

Detection of abnormal signals using AI
AI assists medical personnel in making a definitive diagnosis
Non Risk

NormalNon Risk

DefinitiveDiagnosis

Risk

AbnormalRisk

Collection and maintenance of large
amounts of training data

Machine learning models learn thecharacteristics of decoding patterns

Automatic reading ofabnormal signals by AI
10On-time Alert based on International Guideline

Level 1 - 3 Alert

Alert-CTG analysis tells us when medical
intervention is necessary and the risk level,
which will help medical professionals perform thestandard actions required

Interpretation

Actions Required(per FIGO guidelines)

Level 1: Features
unlikely to be
associated with fetal
compromise whenoccurring in isolation

ObserveIf 2 or more featuresseen, may require
further action

Level 2: Features
MAY be associatedwith fetal
compromise

REQUIRES FURTHERACTION

Level 3: Features are IMMEDIATE
LIKELY to be
MANAGEMENT OR
associated with fetal
URGENT DELIVERY
compromise11

When Midwife should care?
Midwife’s care is 10% of all Risks, and Doctor call should come from Midwife
Interpretation

Percentage of alerts seenin POC Trial (n = 7,157)

Level 1: Features unlikely to be
associated with fetal
compromise when occurring inisolation

89.6%

Level 2: Features MAY be
associated with fetal
compromise

10.0%

Midwife call & Medical Intervention

Level 3: Features are LIKELY tobe associated with fetal
compromise

0.00461%

Doctor call12

1 year Clinical Trial shows an Effectiveness
Alerts Detect Fetal Hypoxia
Potential to avoid preventable deaths by achieving early
medical intervention
With Alert

Non Alert

Average

7.37

＜8.60

25%

1.82

＜

1.95

50%

4.78

＜

5.56

10.48

＜

12.6775%

2.5 minutes early
Fetal hypoxia
is detected13How Alert-Monitor works?
Midwife starts a quick medical intervention and discussion by Alert
Alert History
12:30:32~12:32:27
3 - Danger (Level3)

OK let’s see!

12:25:38~12:27:19
2 - Warning (Level2)
12:22:07~12:22:39
2 - Warning (Level2)

spiker AI recorded Lv2 2 times, so I changed thematernal position. Os uteri is still 4 cm. She is not yet
ready for delivery.
However, the Lv3 alarm is currently sounding.
Doctor, please check this patient.
14Market Size - Estimated 3.6 billion USD

Current Market

Addressable Market

For hospitals equippedwith CTG,
1 billion births per year

For locations where CTG is not
yet available, 50 million births
per year

1.81 billion
USD peryear

1.79 billion
USD per year

Installation Model - 4T1H
Only 4 Alert-Monitor + CTGs will save 2000 babies● 4 Alert-Monitor to 2,000 birth/year Hospital● Realize earlier medical intervention without an additional recruit● Training Provided

Create A World Full of Healthy Newborns

17