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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24
Date of issue for the 1st edition : 2014/07/18
Date of revision : 2021/08/24

Safety Data Sheet

1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Dimethyl sulfoxide
Reference number(SDS):35535jis_E-3
Product type：
Reagent
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
PHYSICAL AND CHEMICAL HAZARDS
Flammable liquids: Category 4
HEALTH HAZARDS
Specific target organ toxicity - single exposure: Category 2(respiratory organs)(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Warning
HAZARD STATEMENT
H227-Combustible liquid
H371-May cause damage to organs
PRECAUTIONARY STATEMENT
PreventionKeep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
Wash contaminated parts thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Do not eat, drink or smoke when using this product.
Response
In case of fire: Use appropriate media other than water to extinguish.
IF exposed or concerned: Call a POISON CENTER/doctor/physician.
Storage
Store in a well-ventilated place.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.
Specific Physical and Chemical hazards
Heating may cause fire.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24
3. Composition/information on ingredients
Mixture/Substance selection:
Substance
Ingredient name:Dimethyl sulfoxide
Content (%):99.0 <Chemical formula:C2H6OS
Chemicals No, Japan:2-1553
CAS No.:67-68-5
MW:78.13
ECNO:200-664-3
Note : The figures shown above are not the specifications of the product.

4. First-aid measures
Descriptions of first-aid measures
General measures
IF exposed or concerned: Call a POISON CENTER/doctor/physician.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation or rash occurs: Get medical advice/attention.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth. Do NOT induce vomiting.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayed(Symptoms when inhalation or ingestion)
Nausea. Headache. Drowsiness. Vomiting.
(Symptoms when skin and/or eye contact)
Dry skin. Conjunctival redness of the eyes. Blurred vision.
※May be absorbed into the skin.

5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use water mist, foam, dry powder, CO2 to extinguish.
Unsuitable extinguishing media
Unsuitable extinguishing media data is not available.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with full face peace operated
positive pressure mode.

6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Ventilate area until material pick up is complete.
Wear proper protective equipment.
Environmental precautions
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb spill with inert material (dry sand, earth, et al), then place in a chemical waste
container.
Preventive measures for secondary accident
Collect spillage.

7. Handling and storagePrecautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe dust/fume/gas/mist/vapors/spray.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong oxidizing agents should not be mixed with the chemicals.
Advice on general occupational hygiene
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

8. Exposure controls/personal protection
Control parameters
Control value in MHLW is not available.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24
Adopted value
Adopted value in JSOH is not available.
Adopted value in ACGIH is not available.
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measuresRespiratory protection
Wear respiratory protection.
Hand protection
Wear protective gloves. Recommended material(s): butyl rubber
Consult with your glove and/or personnel equipment manufacturer for selection ofappropriate compatible materials.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.

9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Liquid
Color: Colorless
Odor: Slightly characteristic odor
Odor threshold data is not available.
Melting point/Freezing point: 18.5℃
Boiling point or initial boiling point: 189℃
Boiling range data is not available.
Flammability (gases, liquids and solids): Ignitable
Lower and upper explosion limit/flammability limit:
Lower explosion limit: 2.6 vol %Upper explosion limit: 42.0 vol %Flash point: (C.C.) 87℃
Auto-ignition temperature: 215℃
Decomposition temperature: >190℃
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity: 2.14mPas(20℃)
Kinematic viscosity data is not available.
Solubility:Solubility in water: Miscible
Solubility in solvent: Freely soluble in ethanol, diethyl ether.
n-Octanol/water partition coefficient data is not available.
Vapor pressure: 59.4 Pa （20℃）
VOC data is not available.
Evaporation rate data is not available.
Density and/or relative density: 1.100(20/4℃)
Relative vapor density (Air=1): 2.7
Relative density of the Vapor/air - mixture at 20℃ (Air = 1) data is not available.
Critical temperature data is not available.
Particle characteristics data is not available.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24

10. Stability and Reactivity
Reactivity
Reactivity data is not available.
Chemical stability
Stable under normal storage/handling conditions.
Hygroscopic.
Possibility of hazardous reactions
The vapour is heavier than air and may travel along the ground; distant ignition possible.
Decomposes on heating and on burning. This produces toxic fumes.
Reacts violently with strong oxidants such as perchlorates.
Conditions to avoid
Contact with incompatible materials.
Open flames. Heat. Sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Carbon oxides, Sulfur oxides

11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[GHS Cat. Japan, base data]
rat LD50=14500mg/kg (MOE risk assessment vol.13, 2015)
Acute toxicity (Dermal)[GHS Cat. Japan, base data]
rat LD50=40000mg/kg (MOE risk assessment vol.13, 2015)
Acute toxicity (Inhalation)[GHS Cat. Japan, base data]
mist: rat LC50 >5330mg/m3/4hr (5.33mg/L/4hr) (SIDS, 2008)
Irritant properties
Skin corrosion/irritation[GHS Cat. Japan, base data]
rabbit (OECD TG 404):Slight erythema, which disappeared in 3 days.(SIDS,2008)
Serious eye damage/irritation[GHS Cat. Japan, base data]
rabbit (OECD TG 405):Slight～moderate conjunctival irritation, which cleared in 3 days.(SIDS,2008)
Allergenic and sensitizing effects data is not available.
Mutagenic effects data is not available.
Carcinogenic effects data is not available.
Reproductive toxicity data is not available.
STOT
STOT-single exposure[cat.2][GHS Cat. Japan, base data]
respiratory system (SIDS, 2008)
STOT-repeated exposure data is not available.
Aspiration hazard data is not available.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/24
12. Ecological Information
Ecotoxicity
Aquatic toxicity
Hazardous to the aquatic environment (Acute)[GHS Cat. Japan, base data]
Crustacea (Artemia salina) EC50=6830mg/L/24hr (MOE risk assessment vol.13, 2015)
Water solubility
miscible (ICSC, 2000)
Persistence and degradability
Persistence and degradability data is not available.
Bioaccumulative potential
Bioaccumulative potential data is not available.
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Dispose of contents/container in accordance with local/national regulation.

14. Transport Information
UN No., UN CLASSUN No. or ID No.: Not applicable
UN Proper Shipping Name : Not applicable
Class or division (Transport hazard class) : Not applicable
Packing group : Not applicableNot applicable to IMDG CodeNot applicable to IATA Dangerous Goods Regulations
Environmental hazards
MARPOL Annex III - Prevention of pollution by harmful substances
Marine pollutants (yes/no) : no

15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
Chemicals listed in TSCA Inventory
Dimethyl sulfoxide
Other regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by your responsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informed by supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

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Dimethyl sulfoxide,JUNSEI CHEMICAL CO., LTD.,35535jis_E-3,2021/08/2416. Other information
GHS classification and labelling
H227-Flam. Liq. 4: H227 Combustible liquid
H371-STOT SE 2: H371 May cause damage to organs
Reference Book
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 21th edit., 2019 UN
IMDG Code, 2018 Edition (Incorporating Amendment 39-18)
IATA Dangerous Goods Regulations (62nd Edition) 2021
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2021 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192020 Recommendation on TLVs (JSOH)
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.11 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020, METI)
Definitions and Abbreviations
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain your safety.
The data given here is based on current knowledge and experience. The purpose of thisSafety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2019).