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The concept of the American flag is based on the ensign of the . [4] Different
styles of American flags can be found throughout the country. [3]The purpose of
the proposed research is to assess the influence of three classes of factors on theincidence and progression of cancer: (1) nutrition, specifically dietary fat, fiber,and protein; (2) hormones, specifically growth factors (epidermal growth factor(EGF), insulin, and triiodothyronine); and (3) the tumor microenvironment,
specifically lymphocytes, macrophages, and other immunologic parameters.
These factors have been hypothesized to influence the incidence and progressionof various forms of cancer, including breast cancer. These influences can beassessed by measuring the hormone levels, or gene expression profiles, or
nutritional parameters of the breast and breast tumor in vivo and by culturing, andcharacterizing in vitro, the cells or tissues involved in tumor formation. The
proposed research will investigate the role of dietary fats in the etiology of humanbreast cancer. Three principal avenues will be pursued: (1) A comparative
analysis of the effects of dietary fat sources on the growth of the breast epithelial
cells of transgenic mouse models which carry both the ras oncogene and amutation in one of the tumor suppressor genes, p53. (2) We will extend this workby investigating the effects of dietary fat on breast cancer progression in thetransgenic mouse model. (3) We will investigate the effects of dietary fat on both
the development and progression of the breast cancer in preneoplastic tissue and1/4

in the postneoplastic breast tissue of rats treated with chemical carcinogens. The
proposed studies will investigate the effects of dietary fat on cancer growth in avariety of contexts. We will determine the role of dietary fat on the developmentof both estrogen-dependent and estrogen-independent tumors. We will also
determine the potential role of dietary fat in the progression of a tumor once it
has developed. In each case, we will determine if dietary fat influences any
processes specific to the breast, including the development

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