KEY Forum: The 5th International Symposium&thThe 39 International Kumamoto Medical Bioscience Symposium

Frontiers in Epigenetics- Health Path and Disease Path & Reproduction Dynamics November 20-22, 2024
Kumamoto City International Center, Kumamoto, Japan

Wednesday, November 20, 2024
13:00-13:10

Opening Remarks
Akira Nakamura (Kumamoto University)

KEY FORUM part 1
Session 1: Early development
Chair: Hitoshi Niwa (Institute of Molecular Embryology and Genetics, Kumamoto University)

13:10-13:45

O1

Alexander Meissner (Max Planck Institute)Non-canonical epigenetic regulation in development

13:45-14:10

O2

Tomohiko Akiyama (Yokohama City University)
The Roles of Sex Chromosome-Encoded Genes in Maintenance andDifferentiation of Human Embryonic Stem Cells

14:10-14:35

O3

Azusa Inoue (RIKEN)
Polycomb regulation in early development

14:35-15:00

O4

Akihiko Sakashita (Keio University)
Retrotransposon-driven regulatory landscapes shape early developmental
program in mammals

15:00-15:20

O5

Mitsuhiro Endoh (Kumamoto University)
The role of Polycomb in maintenance and differentiation of mouseembryonic stem cells

15:20-15:35

BreakSession 2: Reproduction & Germline
Chair:

Kei-ichiro Ishiguro (Institute of Molecular Embryology and Genetics, Kumamoto University)

15:35-16:10

O6

Xin Chen (Johns Hopkins University)
A New Perspective on DNA Replication Components in Stem CellLineages

16:10-16:30 O7Hironori Abe (Kumamoto University)
Sex chromosome-specific epigenetic regulation in male meiosis

16:30-16:50

O8

Joji Watase (Kumamoto University)
Ribosomal DNA copy number maintenance and germline immortality

16:50-17:15

O9

Yuki Okada (The University of Tokyo)
Tracking of Chromatin Dynamics during Spermiogenesis
1 / 417:15-17:40

O10

Yuta Takahashi (Kumamoto University)
Transgenerational inheritance of epigenetic signatures in mammals

Thursday, November 21, 2024
KEY FORUM part 2
Session 3: Chromatin Regulation
Chair:

Ryuki Shimada (Institute of Molecular Embryology and Genetics, Kumamoto University)

09:00-09:25

O11

Makoto Tachibana (Osaka University)
Role of iron metabolism in epigenetic regulation

09:25-09:50

O12

Junichi Nakayama (National Institute for Basic Biology)
Mechanisms regulating Clr4/SUV39H histone methyltransferase activity

09:50-10:15

O13

Atsuya Nishiyama (The University of Tokyo)
CDCA7 is an evolutionarily conserved hemimethylated DNA sensor ineukaryotes

10:15-10:40

O14

Kyohei Arita (Yokohama City University)
Structural basis for inhibition of UHRF1 function by DPPA3

10:40-10:55

BreakSession 4: Development
Chair:

Shinjiro Hino (Institute of Molecular Embryology and Genetics, Kumamoto University)

10:55-11:30

O15

Hongmei Wang (Chinese Academy of Sciences)
Unraveling mammalian placentation across species.

11:30-11:55

O16

Hiroaki Okae (Kumamoto University)
Direct induction of human trophoblast stem cells from late-gestation
placentas

11:55-13:05

Group photo shooting
Lunch & Discussion

Symposium on medical and life science 2024
Session 5: New Technology
Chair:Miki Bundo (Kumamoto University)

13:10-13:30

O17

Kan Etoh (Kumamoto University)
Role of ACLY-mediated citrate metabolism in cellular senescence

13:30-13:50

O18

Yutaka Nakachi (Kumamoto University)
MORE-RNAseq: a pipeline of quantifying the retrotransposition-capable
L1 expression

Session 6: Inflammation
Chair:

Hiroaki Okae (Institute of Molecular Embryology and Genetics, Kumamoto University)

13:50-14:25

O19

Musa Mhlanga (Radboud University)
Epigenetics: at the apex of innate immune memory2 / 4

14:25-14:45

O20

Daisuke Kurotaki (Kumamoto University)
Cis-regulatory code of myeloid cell differentiation during infection

14:45-15:05

O21

Tomoaki Koga (Kumamoto University)
Epigenetic regulation of macrophage polarization

15:05-15:20

BreakSession 7: Cancer& Aging
Chair:

Joji Watase (Institute of Molecular Embryology and Genetics, Kumamoto University)

15:20-15:45

O22

Noriko Saitoh (The Cancer Institute of JFCR)
Nuclear long non-coding RNAs in 3D genome structure and tumor
dormancy

15:45-16:05

O23

Hiroto Ohguchi (Kumamoto University)
Roles of epigenetic regulation in multiple myeloma

16:05-16:30

O24

Takayuki Hoshii (Chiba University)
The SETD1B catalytic domain regulates H3K4me3 breadth and MYC
expression in MLL-rearranged leukemia

16:30-16:55

O25

Motoshi Hayano (Keio University)
Loss of epigenetic information drives aging

16:55-17:15

O26

Jun-ichirou Yasunaga (Kumamoto University)
Epigenetic regulation induced by human T-cell leukemia virus type1; Its
implications for oncogenesis of adult T-cell leukemia

17:15 -Poster session & Reception

Friday, November 22, 2024
Session 8: Lifestyle disease
Chair:

Tomoaki Koga (Institute of Molecular Embryology and Genetics, Kumamoto University)

09:00-09:35

O27

J. Andrew Pospisilik (Van Andel Institute)
Probability, epigenetics and complex disease triggering

09:35-09:55

O28

Yuichiro Arima (Kumamoto University)
Epigenomic Regulation Mediated by Ketone Bodies in Cardiomyocytes

09:55-10:15

O29

Shinjiro Hino (Kumamoto University)
The roles of riboflavin-dependent enzymes in adipose tissue development
and plasticity

10:15-10:30

BreakSession 9: Neuropsychiatry・Transposon
Chair:

Kazuya Iwamoto (Kumamoto University)

10:30-11:05

O30

Geoff Faulkner (University of Queensland)
L1 retrotransposons, somatic mosaicism and gene regulation in themammalian brain
3 / 411:05-11:30

O31

Kenji Ichiyanagi (Nagoya University)
Epigenetic regulation of retrotransposons during male germ cell
development in the mouse

11:30-11:55

O32

Kinichi Nakashima (Kyushu University)
Pathogenic mechanisms driven by endogenous DNA ligands sharedacross models of autism spectrum disorders

11:55-12:20

O33

Yusuke Kishi (The University of Tokyo)
Epigenetic regulation during neuronal aging

12:20-12:40

O34

Miki Bundo (Kumamoto University)
Detection of novel somatic LINE-1 insertions at single neurons ofpatients with schizophrenia

12:40-12:45

Closing Remarks
Yuichi Oike (Kumamoto University)

4 / 4