The majorfinal objectives of this study are to perform a visually evaluate the crystallization mode
observation evaluation of the crystallization modestyle of Ooctacalcium phosphate [OCP:Ca8(PO4)4(HPO4)2・5H2O] oin the porous molded bodies made from biocompatible polymers
and the bonding state of biocompatible polymers and OCP crystal interfaces., Further, this study

Comment [Editor1]: [ Level 3]

intends to evaluate and a evaluation of the mechanical properties of biocompatible polymers[Clarity and Readability]

crystallized usingby OCP, to gain foundational knowledge with respect to the formationon themechanisms of for forming bone and bone-like bone graft materials. In thise present studyHere,[Language]
Clarity and readability was greatly
enhanced by breaking down large

as it was a 1-year-long- studyinvestigation, we selected gelatin, which is ahas biocompatible
polymer,s based and for on which athe protocol for the preparation of porous bodies withof
cancellous bones porous body preparation method has already been established,. Subsequently,and we focused on the evaluation of theis OCP formation mechanism., which This mechanism issentence into smaller parts andimproving word choice.
Comment [Editor2]: [ Level 3][Conjunctive Adverb] [Grammar]

an essential part of calcification in bone formation calcification and is of considerably pivotal

A conjunctive adverb is a part ofimportantce in case offor bones that exhibit acquiring high mechanical strength in bones andspeech that is an adverb by design

degree manifestations of flexibility.

but has the characteristic of a

Furthermore,Not only this the aforementioned mechanism、

it is also essential tofor the prepareation of the high-performancefunctionality biomaterials toconjunction. It can be used to link

which it is applied. Therefore, by combining the two evaluations of the evaluation of the crystal

different clauses or sentences.

interface on a and micro-scale level with that, and evaluation of the mechanical strength ofComment [Editor3]: [ Level 3]

macro-scale bodies formedation, mutual feedback could be provided on the influence that

[Redundancy] [Language]

micro-generated phenomena have on bulk, we could obtain knowledge over a wide range notThe sentences which havepossible with a unidirectional investigation. Therefore, we should be able to obtain a broad range

redundant information aren'tof knowledge that cannot be achieved by separately conducting each of the investigations. Thiscan be achieved by combining the evaluation of the crystal interface on a micro-scale level withthat of the mechanical strength of the macro-scale bodies and obtaining feedback with respect tonecessarily grammaticallyincorrect, but they haveunnecessary words, which affects
overall readability of a sentence.

the bulk influence of the micro-generated phenomena.
OCP is one of thea main inorganic components of young bones, and is a mainly composed ofhighly biocompatible materials. Moreover, Not only that. aAs this unique crystalline structure isable to carry drugs inside the crystal structure, it shows promise as a raw material for new
combination medical materials.Further, OCP is promising as a raw material for the fabrication of
new combination of medical materials because this unique crystalline structure can carry drugs
within the crystal structure.

HoweverOn the other hand, with the use of OCP and , and above

Comment [Editor4]: [ Level 3][Clarity and Readability][Language]
Clarity and readability was greatlyenhanced by rephrasing sentences
and using more appropriate andclearer word choice.

www.crimsonjapan.co.jp

all, with OCP incorporating or carrying pharmaceutical components drug-carrying OCP itself, it
has beenis difficult to obtain molded bodies with the appropriate size and strength that can be to
be utilized as a bone graft material. When OCP powder is simply kneaded into biocompatible

Comment [Editor5]: [ Level 3]

polymers, the resulting materialit does not acquire the become a material with the flexibility of[Spelling error] [Language]

bones, therefore, it is very important to ensure so the crystallization of OCP directly ontoprocess

Spelling error rectified

on the bonee is very important. Controlling OCP crystallization promises to enable preparationof biomaterials with “suppleness” like bone. The control of OCP crystallization enables thepreparation of biomaterials characterized by bone-like “suppleness.”www.crimsonjapan.co.jp