August 2014

Genomic Data Adds Value in Marketing Holstein
Sires Globally
Jetstream Genetics uses Infinium® BovineSNP50 BeadChip-based data to assess thegenetic merit of young elite sires, optimize sire selection, and advance genetics for improved
herd production.
Introduction
With their classic black and white coloring, Holstein cattle are thehighest milk producers of the dairy industry. Jeff Butler and Roger
Turner of Jetstream Genetics have spent their lives driving genetic
improvement of the breed. Growing up on Holstein dairy farms 700
miles apart, they first met as competitors in dairy cattle judging shows.
The award-winning calves and cattle they showed became valued
parents of future offspring. Later, they bought and sold the progenyof those animals as they made their way into the dairy industry, Jeff
as co-owner of Butlerview Farms and Roger as Sire Analyst andInternational Sales Manager at Alta Genetics (1994–2012).
Through the years, they’ve seen a shift from using just phenotypic/
pedigree driven selection towards the addition of genomic information
to improve the accuracy of selection. When coupled with reproductive
technologies such as in vitro fertilization and embryo transfer, thiscombination reduces genetic interval and more rapidly advances theHolstein breed genetically. The transition has taken several decades.
At the competitions that they attended in the 1980s, their cows
were judged solely on conformation traits such as udder shape anddimensions, structure of the skeletal frame, and overall dairy strength
or appearance1. As artificial insemination (AI) and embryo transfer (ET)technologies were integrated into the breeding programs of breeders
to shorten generation intervals, Holstein cattle breeders found they
were breeding unproven dams and sires*, with no guarantee that theresults would be positive. Genomic tools, such as the Illumina Bovine
SNP50K BeadChip, now enable Holstein farmers to assess cattle
through a combined statistical genetic analysis of phenotypic andgenotypic data to make more informed breeding decisions.

In 2012, Jeff launched Jetstream Genetics, an AI marketingorganization, and hired Roger as Global Sales and Genetic Manager.
The company is focused on offering the best sire genetics to theglobal marketplace. iCommunity spoke with Roger to learn howgenetic data from the Illumina Bovine SNP50K BeadChip adds value
to their Holstein sire selection and mating programs.
Q: Why did you choose Holstein sire genetics as the productfocus of your company?
Roger Turner (RT): Jeff and I grew up on dairy farms and have a
combined 60 years of experience raising, breeding, and managing
Holstein herds. We know a lot about the breed. We also recognizethat as members of the food production service industry, dairy farmers
need an efficient product to be successful. The Holstein breed delivers
the highest level of milk production of any dairy breed. For that reason,
it’s popular in North America and worldwide.
Q: When did genetic selection join phenotype-based decisionsin Holstein breeding?
RT: In the 1950s and earlier, breeding decisions were based on
estimated breeding values (EBV)† of cattle within the same herd.
Progeny testing of bulls began in the 1960s, where data was collectedon young sires and their offspring within a herd. In the early 1980s, acomplete genetics-based model came into use. It captured ancestor
and progeny information across herds, reducing herd-to-herd biasand providing a better view of the presence of detrimental andvaluable traits.

View-Home Powerball P epitimizes Jetstream’s focus on delivering the best sire genetics to Holstein farmers worldwide. He is the#1 naturally polled (hornless) sire in the world, scoring 80–90 genomic
total performance index (GTPI) points higher than the next polled bull.
Roger Turner is Global Sales and Genetic Manager at Jetstream Genetics.
*Dams and sires with no milking daughters.

Photo courtesy of Beth Herges†Estimated breeding value is calculated for certain traits based on pedigree information.

August 2014
Q: Did the use of in vitro fertilization (IVF) contribute to the shift
from phenotype- to genotype-based breeding decisions?
RT: It’s been a combination of IVF and genetics that’s empowered
the shift to more genotype-based breeding decisions. Together, they
enable today’s dairy farmers to obtain hundreds to thousands ofcalves from an award-winning sire.
The two technologies developed along parallel tracks. About the timethat progeny testing began to be used, cryogenics and the use ofliquid nitrogen to freeze sperm enabled IVF to shift from a local to amore regional distribution model. Although embryo transfer in cattle
was demonstrated successfully in the 1950s, it wasn’t until the early
1970s that it became widely used. That was just before geneticsbased progeny models began to really take off.
Leveraging the latest advancements in IVF and genetic testing,breeders can now capture more pregnancies by more sires fromyounger females. Unfertilized ovum can be collected from two-month
old heifers or younger, fertilized with young sire semen, and theembryo transferred into a young female for gestation. This shrinks thegeneration interval from 4.3 years to 2.2 years. Achieving a complete
genetic turnover in half the time enables dairy farmers to make huge
strides in advancing genetic progress in their herds.

“We use the BovineSNP50
BeadChip-based Zoetis
HD50K tool to identify known
traits, many of which areresponsible for the success ofcertain cow families.”

Q: How is Jetstream Genetics enabling Holstein dairy farmers totake full advantage of what IVF offers?
RT: Jetstream Genetics was created with the goal of increasing
the use of breed-defining young Holstein sires to improve herds
worldwide. The genes for high milk production come through asire’s paternal and maternal lines. While many market the ovum andembryos of their females, not all dairy farmers are tapping into theearning potential of their sires. Through Jetstream Genetics leased
royalty contracts, dairy farmers receive the full value of the highquality dams they have in their herds. The higher the genetic value
and maternal pedigree of the sire, the higher royalty they’ll receive forits semen. They can then reinvest that royalty income into the female
nucleus of their herd.
Butlerview Farms already has extensive experience in marketingembryos, females, and bulls from the latest generation of Holsteincows. Providing sire genetics enables us to expand our offering to theother half of the IVF equation. We’re not a “brick and mortar” business.

Instead of owning bull housing, we’re partnering with Alta Genetics toleverage their high fertility expertise and logistics experience. With low
operating overhead and high-quality sire genetics, we’re able to returnhigh royalty payments to bull owners.
Q: How important are cow family pedigrees to your customers?
RT: Breeders and their clients are really looking for the depth ofmaternal pedigree. We look at sire stacks—the sire, the maternal
grandsire, the maternal great-grandsire—that have had a lot of
success within the industry. The pedigree provides reliability andcredibility that a high genomically ranked bull will become a proven sirewith daughters in milk production and classification.
Q: What are the important attributes you look for in selecting
Holstein genetic sires?
RT: Conformation, production, health traits, and cow family certainly
play a large factor in our selection. This lineage trait information iscompiled by trained people using a scoring system that classifies
the animals.
When you look at our current lineup, you’ll see a number of sires thatpossess cow family names that are recognized globally. Families like
Regancrest, Missy, and Sonnek. For example, Regancrest S Chassity
has strong confirmation, was a 92 points Gold Medal, and was a Damof Merit for a high-production cow. We have two or three of her sonsand several other male descendants in our lineup. Chassity and her
offspring package have sold for over $1 million USD in 2009 and have
proven to be a great financial investment.
Wesswood-HC Rudy Missy was a former #1 productive life cow. Cows
with high production lactation months directly impact a dairy farmer’scosts. A bull from the Missy cow family can sire several hundred
daughters, increasing productive lactation by several months, andpositively impacting a farm’s bottom line. Missy now has great, great,great-grandsons that have successfully carried on that productive
life trait.
Sonnek Damion Charlie is the Dam of one of our outstanding bulls
called Golddust. He’s the number 2 type bull in the breed today. Hehas been extremely popular since his release and basically sells out
every month of production. What’s unique about the family is that
the Sonnek name (breeding prefix) has been carried under the sameownership for 40 years. Their philosophy of breeding good cows has
withstood the test of time. We now have genomics data identifying
several tremendous females within the Sonnek family.
Q: How many generations of cow family data do you assemble
for each sire sample?
RT: We gather as much generational data from the Holstein
Association as we can, often going back 10–15 generations. It’s
a comprehensive database that includes production classification
and breed award information for all males and females within a cow
family. Generation data validates cow family strength, enhancing thereputation of our product.
We’re proud of the fact that all of our sires expect one have dams thatcarry VG (Very Good) or EX (Excellent) classification scores. We knowof no other sire genetics organization that offers that level of quality.

August 2014
Q: How does the genomic data you obtain from BovineHD
BeadChip-based tools enhance the value of the pedigree data?
RT: The Dairy Herd Improvement Association (DHIA) and the USDAAnimal Improvements Programs Laboratory (AIPL) built a statisticalalgorithm to incorporate genomic information generated with theoriginal BovineSNP50K, and now the BovineHD BeadChip, into thestatistical generational information that’s compiled on these cow
families. Moving forward that information will be compiled by theCouncil on Dairy Cattle Breeding (CDCB).
We use the BovineSNP50 BeadChip-based Zoetis HD50K tool toidentify known traits, many of which are responsible for the successof certain cow families. Traits such as productive life (PL), somatic
cell score (SCS), daughter pregnancy rate (DPR), and sire calvingease (SCE).
Genetic tools also identify new traits that are increasingly requested
by customers, including the gene marker to select for hornless orpolled cattle. Polled bulls eliminate the need to put calves throughthe stressful dehorning process and save farm staff time and money.
However, many polled bulls don’t rate as high in production traits andother attributes. Some dairy farmers haven’t been willing to accept thegenetic loss that polled bulls offer.
We’re pleased to have the #1 polled sire in our lineup, View-Home
Powerball P. He’s about 80–90 genomic total performance index(GTPI) points higher than the next polled bull. He’s the highest priced
young sire ever in the industry, with his semen selling at $1,500 USD
per unit. The average price for Holstein semen is $20–30 USD per unit.
He’s attracted a lot of attention and generated many sales in a shorttime.
Q: Are there any other new markers that represent traits valued
by customers?
RT: In addition to all the modern day markers that deliver strong
conformation and classification traits, there are several newly identified
genetic traits that are attractive to international customers. In certain
Europe countries, red and red carrier cattle are valued highly. Red hairis a recessive Holstein trait and these cows are red and white, rather
than black and white. Red and red carrier Holsteins offer higher milk
production, good somatic cell count, and high conformation scores.
In Australia, milk containing A2 beta casein is considered to have
health benefits. Beta casein is one of six milk proteins and is producedby the CSN2 gene. We can identify the A2/A2 beta casein CSN2
variant through genetic testing. There are some herds in Australia thatare moving to 100% A2/A2, generating a 20% premium based onthat milk quality. Including data on that variant enables us to compete
effectively in the Australian market.
Q: Do you have data on the impact your sire genetics have hadon dairy herds?
RT: The progeny from our bulls are not into milk production yet, so
it’s a little early in our lifecycle to look at production levels. We’ve
had many repeat customers because we’ve shown them the valueof high elite genomic young sires providing a next generation forthem. Our early customers have captured revenue from the sale ofmale and female offspring from our sires. They’re already creating thenext generation through embryo transfer and IVF, so we’ll soon havematernal grandsires in the lineage that we’ll follow to track production
and genetic traits.
We’ll also get some of that information through the CDCB. We
remain in constant contact with our customers to receive fertility andcalving ease reports. As the animals are registered into the Holstein
USA breed database and move into production, we’ll be tracking
the daughters and add that information about proven sire status into
our reports.

“Genomics also enables us
to capture new opportunities
through the identification of new
trait-linked markers, such as thepolled, red and red carrier, andA2/A2 genes.”
Q: Are there certain reports that must accompany every
exported sample?
RT: Holstein USA has been around for 125 years and the integrityof their database is recognized throughout the world. When data
becomes available on the offspring from our sire genetics, we canobtain DNA reports from Holstein USA with official 3–5 generation
pedigrees to accompany the semen samples we export. It’s part ofthe protocol that’s put in place within the industry to maintain a highlevel of integrity.
We’re in about 30 and 35 markets internationally. There is a highdemand globally for U.S. and North American Holstein genetics. Dairy
farmers in the rest of the world have seen the increase in productivity
and efficiency achieved here and the reliability that genetic testing
provides. By marketing Holstein sire genetics, we’re enabling dairy
farmers worldwide to improve their herds and offering U.S. and North
American dairy farmers with a revenue stream to enhance their farms.
Q: How have genomics and Illumina Bovine BeadChip-based
tools enhanced your business?
RT: We’ve been using Illumina Bovine BeadChips for years at
Butlerview Farms and now at Jetstream Genetics. We started withthe BovineSNP30K BeadChip, moved up to the BovineSNP50K, andnow work with BovineHD (80K) BeadChip-based tools. The data these
BeadChips provide add value and accuracy to the reports we provide
customers.
Honestly, we couldn’t be in this business without genomics. We’reable to assess the genetic value of an animal when it’s 30–40 days
old, which enhances our business and enables customers to validate
the impact of our sire genetics quickly.

August 2014
Genomics also enables us to capture new opportunities throughthe identification of new trait-linked markers, such as the polled, redand red carrier, and A2/A2 genes. Without the data showing thatView-Home Powerball P carries the polled and A2/A2 genes, he would
be just another Holstein bull.
Q: Do you need to educate any of your customers on the valueof genetics?
RT: As a judge at dairy breed competitions, I’ve meet dairy farmers
from over 20 countries and can see that the use and understanding ofgenomics has grown over the past decade. Yet, the education process
is ongoing and a part of every conversation we have with clients.
Teaching them about dairy genetics creates value and adds anotherlink to our relationship with dairymen around the world.

After the daughters of our genomic sires are into milk production, we’ll beable to market proven sires as well. The combination of pedigree, lineage
trait information, and genomic and proven sire data will enable us toprovide comprehensive reports to our worldwide customers.

References
1. www.holsteinfoundation.org/pdf_doc/workbooks/Dairy_Judging_Workbook.pdf (7 July 2014)

Learn More
Go to www.illumina.com/applications/agriculture.ilmn to learn more
about Illumina agrigenomics technologies.

Jetstream Genetics is unique in that Jeff can provide information on
the female side of Holstein breeding. With Butlerview Farms, he’s
established an elite ranked female nucleus herd. He’s constantly
buying and selling elite females and understands the value genetics
brings in supporting those decisions. With Jetstream Genetics offering
sire genetics, we can help customers understand how genomics
impact both sides of the Holstein reproductive equation.

“I think the accuracy andacceptance of genomics isgrowing worldwide, which
will enhance our businessand enable us to enter
new markets.”
Q: What are the next steps in your business?
RT: I think the accuracy and acceptance of genomics is growing
worldwide, which will enhance our business and enable us to enter
new markets. Some countries have taken longer than others to accept
genomic young sires into their breeding programs. For example, Poland
will finally be opening its markets for genomic young sires by the end of
the year.

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Pub. No. 1370-2014-007 Current as of 04 August 2014