COINS Seminar #49【Date】24/October/2019 (Thu.) 16:00-17:15 (Registration Open at 15:30)＊Research Mixer 17:15-18:15 *JPY500【Venue】Innovation Center of NanoMedicine (iCONM) 3F 3001 Meeting room
【Registration】URL: https://www.cis-trans.jp/coins_seminar49/index.html
Title:Multivalent Nanosystems and Supramolecular Dendritic Architectures
Abstract:Multivalency is a ubiquitous phenomenon in nature involving complex binding mechanisms
for achieving non-covalent strong yet reversible interactions. Interfacial multivalent interactions atpathogen-cell interfaces can be competitively inhibited by multivalent scaffolds that prevent pathogen
adhesion to the cells during the initial stages of infection, while monovalent inhibition fails to inhibit thebiological pathway. The lack in understanding of complex biological systems makes the design of an
efficient multivalent inhibitor a toilsome task and is the reason why as of yet no multivalent anti-infective
has emerged on the market until now. This talk will focus on the design and application of dynamic 2Dand 3D multivalent nanosystems as potent inhibitors for pathogens.
Speaker:Prof. Dr. Rainer HaagAffiliation:Freie Universität Berlin, Germany
Position:Chair Professor of Organic and Macromolecular Chemistry,
Department of Chemistry and Biochemistry
URL:www.polytree.de＜CV＞
Rainer Haag, born 1968, is Full Professor in Organic and Macromolecular Chemistry at the Freie
Universität Berlin. Since 2008 he is the head of a collaborative research center SFB 765 “Multivalencya chemical organization and action principle”. His research interests are dendritic polymers as highly
functional polymeric supports for catalysis, macromolecular nanotransporters for DNA- and drugdelivery and protein resistant material surfaces. In 2004 his group was awarded the young investigator
NanoFutur award from the German Ministry of Science (BMBF) and in 2010 the Athur K. Doolittle
Award of the American Chemical Society (ACS) for their work on “multifunctional nanotransportsystems”. He is also advisor for two start-up companies (nanopartica and Dendropharm) that license thegroup’s technology. With Dendropharm he received the Innovation award Berlin-Brandenburg 2016.
Rainer Haag completed his PhD thesis (1995) on Highly Strained Acepentalene Derivatives with Prof.
A. de Meijere, University of Göttingen, Germany. In 1994 he joined the group of Prof. M. Rabinovitz,Hebrew University, Jerusalem (Israel) as a Research Fellow. In 1996-1997 he worked as a Postdoc with
Prof. S. V. Ley, University of Cambridge (England) on the total synthesis of Spongistatine and soluble
polymeric supports for combinatorial synthesis. As a research fellow (1997-1999) with Prof. G. M.
Whitesides, Harvard University, Cambridge (USA) he worked on the electronic properties of selfassembled monolayers, nanostructuring of surfaces and multivalent drugs. From 1999 until 2002 hecompleted his habilitation on “Dendritic Polymers as High-loading Supports for Organic Synthesis andDrug-Delivery” and was research group leader at the Materials Research Center (FMF) of the Universityof Freiburg (Mentor: Prof. Rolf Mülhaupt). He is recipient of the ADUC-Habilitanden prize 2000, theReimund-Stadler prize 2001 and the Heinz-Maier Leibnitz prize 2002 of the German Chemical Society.
In 2003 he received the Dozenten Award of the German Chemical Industry. He was a co-founder ofHyperpolymers, a company specialized on dendritic polymers. In May 2003 he became Associate
Professor in Organic Polymer Chemistry at the University of Dortmund. In 2004 Rainer Haag accepteda Chair position at the Freie Universität Berlin.
＜Award＞
2019 JSPS International Fellowship for Research in Japan
2016 Innovation Award Berlin-Brandenburg with the startup company DendroPharm2015 Research Building “SupraFAB” (granted by the German Research Council)
2014 Teaching Award for the Concept “Translation of Project Ideas”, Freie Universität Berlin
2014 Honorary Life-time Fellow of the Indian Society of Biology and Chemistry2010 Arthur Doolittle Award of the American Chemical Society (ACS)2004 Nanoscience Award for Young Scientists from the Ministry of Science (BMBF)
2003 Early Career Award of the German Chemical Industry (VCI)
2002 Heinz Maier-Leibnitz-Prize of the German Science Foundation (DFG)
2001
Reimund-Stadler-Prize of GdCh-Division Macromolecular Chemistry2000 ADUC-Habilitation-Award of the German Chemical Society (GDCh)1997
Selected Member of the Study Foundation of the German People＜Key words＞
multivalency, nanosystems, monocytes/macrophages, inflammatory diseases*Supported by: COINS（JST, COIProgram）, Innovation Center of NanoMedicine（iCONM）