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7.000

7.000

6.000

6.000

5.000

5.000

1-1䡚3: ᐇ㦂༊䠍䚸ῧຍ䛺䛧2-1䡚3: ᐇ㦂༊䠎䚸100 ppm䜰䝇䝍䜻䝃䞁䝏䞁3-1䡚3: ᐇ㦂༊䠏䚸䜽䝻䝺䝷1%
4-1䡚3: ᐇ㦂༊䠐䚸䜽䝻䝺䝷2%
5-1䡚3: ᐇ㦂༊䠑䚸䜽䝻䝺䝷5%mg/䜶䝡100g䜶䝡㔜㔞䠄g䠅(n=3 bar: SD)

4.000

4.000

3.000

3.000

2.000

2.000

1.000

1.000

0.000

0.000
1-1 1-2 1-3 2-1 2-2 2-3 3-1 3-2 3-3 4-1 4-2 4-3 5-1 5-2 5-3ヨ㦂༊䠄Ỉᵴẖ䠅ᢠ⪁໬䈜

㻺㼛㻚

8.000

8.000

1-1 1-2 1-3 2-1 2-2 2-3 3-1 3-2 3-3 4-1 4-2 4-3 5-1 5-2 5-3

ᢠ⅖⑕ᢠ⫧‶䈜㻹㼀㼀䠉䠉䠉䠇䠇䠇䠉䠉䠉䠉䠇䠇䠇䠉䠇䠇䠇䠇䠉䠉䠇䠉䠇䠇䠉䠉䠉䠉䠇䠇䠇䠇䠇䠉䠇䠇䠇䠉䠉㻺㻚㻱䠉䠇䠇䠇䠉䠇䠇䠉䠇䠇䠇䠉䠇䠇䠉䠉䠉䠇䠉䠉䠉䠇㻺㻚㻱䠇䠇䠉䠉䠉䠉䠉䠉䠇䠉䠉䠇䠉䠉䠉䠉䠉㻺㻚㻱䠇䠇䠇䠇䠉䠉䠇䠉䠉䠉䠇䠉䠉䠇䠇䠇䠉䠉䠉䠉䠉䠉䝸䞁㻴㻞 㻻㻞㻝㻞㻟㻠

KI52
KI59
KI69
YM51

䠇䠇䠇䠇䠇䠇䠇䠇䠉䠇䠇䠇䠇䠇䠇㻡

MD88

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KI55
KI88
KI70
KI38
MD50
KI56
KI00
KI01
MD52
KIKK
KI1a
MD7a
AK75
AK12
AK32
YM69
YM79
MD67

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7ZRV\PSRVLDRUJDQL]HGDW 87)&ਸ਼‫ڭ‬৚঑ॽ३থএَਃચਙংॖड़‫؟‬๶಍ᇖథध౞ણ৷ে੟ৱ౺ُ঩ৎ ফা঩‫ق‬਷‫ك‬‫؟ع؟‬૞ਸ঻ਯ ੡Precursor of cholesterol➨䠎 ᅇ䝭 䝙䝅 䞁 䝫ᶵ⬟ᛶ䝞䜲 䜸䠖 ᚤ⣽⸴㢮䛸 ᮍά⏝⏕≀㈨※䇷䛴䛟 䜀䞉 ᯽䛾༠๰䜢 ┠ᣦ䛧 䛶 䞊᪥᫬䠖 2 0 1 7 ᖺ3 ᭶2 9 ᪥䠄 Ỉ䠅 1 5 䠖 0 0 䡚1 8 䠖 0 0 䠇஺ὶ఍ሙᡤ䠖 ᮾி኱Ꮫ᯽䛾ⴥ䜻䝱 䞁 䝟䝇 㥐๓䝃䝔 䝷 䜲 䝖䈜䛴䛟 䜀䜶 䜽 䝇䝥 䝺 䝇 䛂 ᯽䛾ⴥ䜻䝱 䞁 䝟䝇 㥐䛃 すཱྀ䜘 䜚 ໭䜈ᚐṌ1 ศ୺ദ䠖 TI A䛛䛡䛿䛧 ◊✲䛂 ᶵ⬟ᛶ䝞䜲 䜸䛃 䜾䝹䞊䝥䞉 䛿䛨 䜑䛻䡚TI A䛸 䛴䛟 䜀䞉 ᯽䛾༠๰䜢 ┠ᣦ䛧 䛶 ( 1 5 䠖 0 0 䡚1 5 䠖 1 0 )ᒣ㊰୍㝯䠄 ᮾி኱Ꮫ䞉 TKHiC᥎㐍‽ഛᐊ䠅䞉 ᶵ⬟ᛶ䝞䜲 䜸䛾᪂䛧 䛔ヨ䜏䠄 1 5 䠖 1 0 䡚1 6 䠖 4 0 䠅ᗙ㛗䠖 Ἑ㔝㔜⾜䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅⸴㢮䝞䜲 䜸䝬 䝇 䛾ຠ⋡ⓗ฼⏝䛻ྥ䛡䛯䝎䜴䞁 䝇䝖 䝸 䞊䝮䝥 䝻 䝉䝇 䛾㛤Ⓨᕷᕝ๰స䠄 ⟃Ἴ኱Ꮫ䞉 ⏕࿨⎔ቃ⣔/ ABES䠅 ( 3 0 m in)⸴㢮䝞䜲 䜸䝬䝇 䜢 ฼⏝䛩䜛 ⢭ᐦ᭷ᶵྜᡂ ( 3 0 m in)᭷ᮧ㝯ᚿ䠄 ⏘⥲◊䞉 ゐ፹䝉䞁 䝍 䞊䠅ᶵ⬟ᛶᡂศ䛻䜘 䜛 ㄆ▱⑕ண㜵䛾ྍ⬟ᛶ ( 3 0 m in)ஂᜏ㎮༤䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅䞉 䝁 䞊䝠 䞊䝤 䝺 䜲 䜽 䠄 1 6 䠖 4 0 䡚1 7 䠖 0 0 䠅䞉 ⸴㢮䝞䜲 䜸䛸 ᪂䛯䛺䝰䝙䝍 䝸 䞁 䜾ἲ䛾ヨ䜏䠄 1 7 䠖 0 0 䡚1 8 䠖 0 0 䠅ᗙ㛗䠖 㛛⬥࿴⏨䠄 ⟃Ἴ኱Ꮫ䞉 ABES䠅㠀⥺ᙧගᏛ⌧㇟䛻䜘 䜛 䜸䞊䝷 䞁 䝏䜸䜻䝖 䝸 䜴䝮䛾⣽⬊ෆᵓ㐀ゎ ( 3 0 m in)ྜྷ⏣ᫀᶞ䠄 ⟃Ἴ኱Ꮫ䞉 ⏕࿨⎔ቃ⣔/ ABES䠅ᚤ⣽⸴㢮䝰 䝙䝍 䝸 䞁 䜾䝅 䝇䝔 䝮䛾ά⏝ ( 3 0 m in)኱▮⚞୍䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅䞉 ᨭ᥼䝛䝑 䝖 䝽䞊䜽 䛻䛴䛔䛶䠄 1 8 䠖 0 0 䡚1 8 䠖 1 5 䠅ᗙ㛗䠖 ᐩỌ೺୍䠄 ⏘⥲◊䞉 ゐ፹䝉䞁 䝍 䞊䠅⏘⥲◊䛂 㣗䞉 ⸆䞉 ᮦ䝁 䞁 䝋 䛃 䛻䛴䛔䛶 ( 1 5 m in)ὸᕝ┿⃈䠄 ⏘⥲◊䞉 ゐ፹䝉䞁 䝍 䞊䠅䞉 䛚䜟䜚 䛻䡚ᚤ⣽⸴㢮䛸 ᮍά⏝⏕≀㈨※䠄 1 8 䠖 1 5 䡚1 8 䠖 2 5 䠅Ώ㑓 ಙ䠄 ⟃Ἴ኱Ꮫ䞉 ABES䠅 䞉 Ἑ㔝㔜⾜䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅஺ὶ఍䠄 1 8 䠖 3 0 䡚2 0 䠖 0 0 䠅2 㝵䝷 䜴䞁 䝆䈜ୖグ䛾䝭 䝙䝅 䞁 䝫䜢 TI A䛛䛡䛿䛧 ◊✲䛂 ᶵ⬟ᛶ䝞䜲 䜸䛃 䜾䝹䞊䝥 䛾୺ദ䛷㛤ദ䛧 䜎 䛩䚹 ཧຍ䛿↓ᩱ䛷䛩䚹 䝭 䝙䝅 䞁 䝫ᚋ䛻䛿஺ὶ఍䜢 ணᐃ䛧 䛶䛔䜎 䛩䚹 ஺ὶ఍䛾ཧຍ㈝䛿䚸 ୍⯡3 ,0 0 0 ෇䚸 䝫䝇 䝗 䜽 䞉 Ꮫ⏕
1 ,0 0 0 ෇䛷 䚸 ᙜ᪥఍ሙ䛻䛶 ᚩ཰䛧 䜎 䛩䚹 䝭 䝙䝅䞁 䝫䛚䜘 䜃஺ὶ఍䜈䛾ཧຍ䛿䚸3 ᭶2 1 ᪥䠄 ⅆ䠅 䜎 䛷 䛻䚸 䝯 䞊䝹< t.takeshita@edu.k.u- tokyo.ac.jp> 䛛䝩䞊䝮䝨䞊䝆
http:/ / park.itc.u- tokyo.ac.jp/ functionalbio/ 䛷⏦䛧 ㎸䜏ୗ䛥 䛔䚹䈜ᙜ᪥ཧຍ䜒 Ḽ㏄䛧 䜎 䛩䚹䠘ୡ ヰ ே䠚Ἑ㔝㔜⾜䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅 kaw ano@k.u- tokyo.ac.jp♒⏣༤Ꮚ䠄 ⟃Ἴ኱Ꮫ䞉 ABES䠅 isoda.hiroko.ga@u.tsukuba.ac.jpᐩỌ೺୍䠄 ⏘⥲◊䞉 ゐ፹䝉䞁 䝍 䞊䠅 k- tom inaga@aist.go.jpཧຍ㐃⤡ඛ䠖 ➉ୗ Ẏ䠄 ᮾி኱Ꮫ䞉 ᪂㡿ᇦ䠅 t.takeshita@edu.k.u- tokyo.ac.jp• 7,$৴௚উটॢছ঒ർด௓ਤহ঵َऊऐमखُ‫؟‬ᇖథংॖड़ઙभਃચਙ૥ୡध७ঝইওॹॕॣ‫ش‬३ঙথৎ৻भৗ৘ৃ৫ิਸ਼৚঑ॽ३থএَਃચਙংॖड़‫؟‬๶಍ᇖథध౞ણ৷ে੟ৱ౺‫ص‬णऎय‫؞‬ฃभੈ൉॑৯੐खथُ• বয়ଢ଼஢৫৅১যఐ৾ૼ୒ஷ௪ਃଡ‫ق‬-67‫؞ك‬ਅറ৓൉ୗଢ଼஢௓ਤহ঵ ॳ‫ش‬঒஑ଢ଼஢‫&ق‬5(67‫َ ك‬ᇖథ‫؞‬਷෠๶ে੟भਃચੰ৥ध਑౪पेॊংॖड़ग़ॿঝॠ‫ش‬൉ਛभञीभ੦ೕૼ୒भ൉লُ
• বয়ଢ଼஢৫৅১যఐ৾ૼ୒ஷ௪ਃଡ‫ق‬-67‫؞ك‬প৾৅ৗਓ঵൉লউটॢছ঒
‫ق‬67$57‫َك‬ॡটঞছपेॊളਯ౦भढ़টॸঀॖॻधশำਂᆳਮ࿫ᆅ෷भপ୤েਓُ঩ৎ ফা঩‫ق‬਷‫ك‬‫؟ع؟‬૞ਸ঻ਯ 54 ੡⏬ീฟ඾䠙http://www.fc.u-tokyo.ac.jp/en/category/library/୕ె௏঳‫ق‬ਓ੕ଢ଼‫ؚك‬᰽ি೗৕‫ق‬໒ణপ‫؞‬ਓ੕ଢ଼‫ك‬ଢ଼‫ك‬ఖ৙੎ষ‫ূق‬਎প৾ ৗ୩ୠ‫ূؚ‬প)&‫ك‬NDZDQR#NXWRN\RDFMS 6.DZDQR