KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 1 Identification of the substance/ mixture and of the company/ undertaking
1.1 Product identifier
Product name
KOD -Multi&Epi-TM
2x Buffer for KOD -Multi&Epi-TM
Product CodeKME-101, KME-159, KME-1B1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Recommended use and PCR kit
restrictions on use
1.3 Detail of the supplier of the safety data sheet
CompanyTOYOBO Co., Ltd.
Department
Biotech support Department
Address
2-2-8 Dojima Hama Kita-ku Osaka, 530-8230 Japan
Telephone number+81-6-6348-3786
Fax No.
+81-6-6348-3833
1.4 Emergency telephone number+81-6-6348-3786 (9:00~17:00 Japan Time)SECTION 2 Hazards identification
2.1 Classification of substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Not classified or classification not possible
2.2 Label elements
Classification (REGULATION (EC) No 1272/2008)
No label elements are required.
2.3 Other harzards
Few adverse human health effects are anticipated. Glycerol whose
flash point 160℃ is contained.

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 3 Composition / information on Ingredients
Chemical ProductMixture(Substance/Mixture)
3.2 Mixture
Chemical Nature
Aqueous solutions of enzyme and other compounds.
Harzadous components
Trometamol
Common Chemical
GlycerolTris(hydroxymethyl)aminomethSynonyms
Glycerin
aneTM
Contained Parts
KOD -Multi&Epi-TM, 2x Buffer
KOD -Multi&EpiChemical formula
CAS No.
EC No.
Classification

CH2OHCHOHCH2OH
56-81-5
200-289-5
Not classified

Concentration<5%Common ChemicalNameSynonyms
Contained Parts

Poly(oxyethylene)nonylphenylether
Nonidet P-40
KOD -Multi&Epi-TM

Chemical formula
CAS No.
EC No.
Classification

HO(C2H4O)n-C6H4-C9H199016-45-9
500-024-6

Concentration
Common Chemical
Synonyms
Contained Parts
Chemical formula
CAS No.
EC No.
Classification

Concentration

Skin Irrit. 2 H315,
Eye Irrit. 2 H319,
Aquatic Chronic 2 H411
PBT
0.05%
Additive22x Buffer for KOD -Multi&Epi-TM
Skin Irrit. 2 H315,
Eye Irrit. 2 H319,
STOT SE 3 H335
<5%for KOD -Multi&Epi-TM
C4H11NO377-86-1
201-064-4
Skin Irrit. 2 H315,
Eye Irrit. 2 H319,
STOT SE 3 H335
<5%Additive1
2x Buffer for
KOD -Multi&Epi-TM
Not classified<40%

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 4 First aid measures
4.1 Description of first aid measures
Inhalation
In case of irritation by inhaling this product, remove person to fresh
air and keep comfortable for breathing. Seek medical attention.
Skin Contact

Wash with clean water, immediately.
Take off contaminated clothing and wash before reuse.
If skin irritation or rash occurs: Get medical advice/ attention.
Rinse cautiously with water for several minutes.
Eye Contact
Rinse mouth.Induce vomiting.
Ingestion
If indisposition continues, seek medical attention.
4.2 Most important symptoms and effects, both acute and delayed
No information available.
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5 Firefighting measures
5.1 Extinguishing media
Water, Carbon Dioxide, Foam, Dry Chemical Powder
5.2 Special hazards arising from the substance or mixture
Exposure to decomposition products may be a hazard to health.
Toxic gas (carbon monoxide, nitrogen oxides) and fumes maybe
generated.
5.3 Advice for firefighters
Fire-fighting should be done from the windward side of fire area.
Fire-fighters should wear proper protective equipment in case oflarge scale fire.
SECTION 6 Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Wear protective equipments and avoid eye/skin contact andinhalation.
6.2 Environmental precautions
Avoid disposition to the environment.
6.3 Methods and material for containment and cleaning up
Use cloth, paper, or anything similar to soak up to the solution
leaking out of the container.
6.4 Reference to other sections
For personal protection see section 8.

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 7 Handling and storage
7.1 Precautions for safe handling
Avoid substance contact. Wear protective equipments and avoid
Technical Measurescontact with eyes and skin. Handle with ventilation and local
exhaust system.
Precautions
Keep the handling area always clean.
Wash hands thoroughly after handling.
Hygiene measures
7.2 Conditions for safe storage, including any incompatibilities
Storage Conditions
Store at about -20℃
Packaging Materials
Store in the original package
7.3 Specific end uses (s)Laboratory chemicals
SECTION 8 Exposure controls/ personal protection
8.1 Control Parameter
Occupational Exposure Limits
Glycerol
JSOH OEL
OSHA PELDFG MAKNot established
Total dust: 15mg/m3TWA
Respirable fraction: 5mg/m3TWA
Inhalable fraction: 200 mg/m3
Peak limitation category: I(2)8.2 Exposure controls
Appropriate enginerring controls
Set up good ventilation and exhaust system in the work area.
Personal protective Equipment
Respiratory Protection Wear a dust mask.
Hand Protection
Chemical safety gloves.
Eye Protection
Chemical safety goggles.
Skin and Body
Long sleeves to prevent contact with skin.
Protection

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 9 Physical and chemical properties
9.1 Information on basic physical and chemical properties
LiquidPhysical StateColourOdour
pH
Flash Point

DensitySolubility
9.2 Other data

ColourlessNone
7.0～9.0
No flammability due to aqueous solution, but glycerol whose flash
point 160℃ may stay behind after volatilization of KOD -Multi＆Epi-TM.
1.0-1.2
Soluble in water.
None

SECTION 10 Stability and reactivity
10.1 Reactivity
No hazardous reaction if stored and applied as directed.
10.2 Chemical stability
Stable at -20℃.
10.3 Possibility of hazardous reactions
Nothing particular10.4 Conditions to avoid
High temperature, ignition sources, direct sunlight10.5 Incompatible materials
Strong acids, strong alkalines and strong oxidizers10.6 Hazardous decomposition products
Not available

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 11 Toxicological information
11.1 Information on toxicological effects
Not available
Acute Toxicity
May cause skin irritation.
Skin corrosion/
May cause eye irritation.
Serious eye damage/irritation
Toxicological information on the component of this product
Poly(oxyethylene)nonylphenyl
Glycerolether
Acute toxicity
Oral-rat: LD50 12.6g/kg
Dermal-rabbit: LD50 >10g/kg－Inhalation-rat: LC50>570mg/m3(1hr)－Irritating to skin.
Skin corrosion/irritation－
Irritating to eyes.
Eye damage/ irritation

Skin corrosion/irritation
Eye damage/ irritation
Specific target organ
toxicity(single

Skin corrosion/irritation
Eye damage/ irritation
Specific target organ
toxicity(single

Trometamol
Irritating to skin.

Additive1
May cause irritate skin.

Irritating to eyes.
May cause respiratory irritation

May cause irritate the eyes
－Additive2
Irritating to skin.
Irritating to eyes.
May cause respiratory irritation

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 12 Ecological information
12.1 Toxicity
Poly(oxyethylene)nonylphenylether
Acute
Crustacea (Mysidopsis bahia);
LC50/48H 0.71-2.2mg/L
Aquatic chronic
Fishes (Pimephales promelas);
NOEC/7D 1mg/L
12.2 Persistence and degradability
Glycerol and enzyme are biodegradable.
12.3 Bioaccumulative potential
Glycerol and enzyme are not bioaccumulative.
12.4 Mobility in soil
Soluble in water and diffusible into water environment.
12.5 Results of PBT and vPvB assessmentThis product does not contain any PBT and vPvB substances atlevels of 0.1% or higher.
SECTION 13 Disposal considerations
13.1 Waste treatment methods
Dispose of in accordance with all applicable local and national laws
Productand regulations.
Dispose of in accordance with all applicable local and national laws
Contaminatedand regulations.
Packaging
SECTION 14 Transport information
14.1 UN number
No
14.2 UN proper shipping nameNo
14.3 Transport hazard class(es)No
14.4 Packing groupNo
14.5 Environmental hazards
Not classified as environmental harzards.
14.6 Special precautions for userTo prevent packages from breaking, handle with care.
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC CodeNot applicable for product as supplied.

KOD -Multi&Epi-TM
First issue : Jun. 12, 2019
SDS No.1728F

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006
SECTION 15 Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or
mixtureRegulation (EC) No 649/2012 of the European Parliament and the Council concerning theexport and import of dangerous chemicals
Not applicable
REACH - Authrization List of Substances of Very High Concern for Authorisation (Annex
Poly(oxyethylene)nonylphenyl ether
Regulation (EC) No 1005/2009 on substances that deplete the ozone layer
Not applicable
Regulation (EC) No 850/2004 on persistent organic pollutants
Not applicable
Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on thecontrol of major-accident hazards involving dangerous substances.
Not applicable15.2 Chemical Safety Assessment
No data available
Follow all of the laws and regulations in your respective country.
SECTION 16 Other information
Full text of HH315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H411: Toxic to aquatic life with long lasting effects.
Full text of other abbreviations
Skin Irrit. : Skin irritation
Eye Irrit. : Eye irritation
STOT SE: Specific target organ toxicity - single exposure
Aquatic Chronic: Chronic aquatic toxicity
Notice

The information in this SDS, to the best of our knowledge, isaccurate and correct. However, TOYOBO makes no warranty andassumes no liability whatsoever in connection with any use of thisinformation.
The SDS is subject to revision as new information becomes
available.