Otsuka Pharmaceutical India Private Limited

Product
Catalogue

Total Nutrient Admixture
TNA/ TNA-Peri
Amino Acids with Electrolytes, Dextrose and Lipid Emulsion Injection^

Description• The concept of Total Nutrient Admixture is to provide all macronutrients including
amino acids, lipids and carbohydrates in a single delivery system. The objective is to provide
nutritional support to maintain the nitrogen-energy balance which may be altered bymalnutrition and diseased condition.
• TNA is recommended to be infused only into central vein.
• TNA-Peri can be infused either through a central or peripheral vein.

Indications
Parenteral nutrition for adults where oral or enteral route for nutrition is not available, notpossible, not sufficient or contraindicated.

Composition
Brand Name
TNA

TNA-Peri^ Product Package Insert

Description / Generic Name
Combipack of:
1. Amino acids (10% w/v) Injection with Electrolytes(400 ml/ 600 ml)
2. Glucose Intravenous Infusion (300 g/L)
(400 ml/ 600 ml)
3. Intravenous Fat Emulsion with Medium & Long
Chain Triglycerides(20% w/v)-(200 ml/ 300 ml)
Combipack of:
1. Amino acids (10% w/v) Injection with Electrolytes(300 ml/ 450 ml)
2. Glucose Intravenous Infusion (150 g/L)
(530 ml/ 795 ml)
3. Intravenous Fat Emulsion with Medium & Long
Chain Triglycerides(20% w/v)-(170 ml/ 255 ml)

Volume (ml)1000, 1500

1000, 1500

Parenteral Amino Acids Solutions
CELEMIN
Amino Acids Injection with/without Electrolytes ^Description
CELEMIN is a clear, colourless to faintly yellow colored solution containing well balanced mixtureof pure crystalline, essential and nonessential amino acids, which are in optimum concentration
for protein synthesis.
The infusion is available in following formulations :CELEMIN 5-S (Amino Acids (5% w/v) & Sorbitol (5% w/v) Injection), CELEMIN 5-S PLUS (Amino
Acids (5% w/v) & Sorbitol (10% w/v) Injection with Electrolytes), CELEMIN 10 PLUS (Amino Acids(10% w/v) Injection with Electrolytes) and Celemin Infant (Amino Acids (10% w/v) Injection).
The infusion could be given either by peripheral or central route by suitably adjusting the flowrate.

Indications
CELEMIN is indicated as a parenteral nutrition supplement in the following conditions.
• Prophylaxis and therapy for protein deficiency • Pre and post operative conditions• Inadequate or impossible oral feeding, e.g. following operative procedures on gastrointestinal
tract, gastrointestinal bleeding, corrosive injuries to oesophagus or stomach • Stenosis in thegastrointestinal tract • Inflammatory Bowel Disease and Short - gut Syndrome • Chronic
Diarrhoea and Vomiting • Malabsorption syndrome • Sepsis • Diffuse peritonitis • Fistulas• Chylous ascites • Persistent Pyrexial state • Malnutrition and Clinical outcomes • Nephrosis,
Amyloidosis • Immuno compromised patients • HIV Infection • Transplantations • Cancer andrelated cachexia • Burns • Pregnancy • Head Injuries • Prolonged Coma.

Composition
Brand Name

Description / Generic Name

Volume (ml)100, 200, 250, 500

CELEMIN 5S

Amino acids (5% w/v) and Sorbitol (5% w/v) Injection

CELEMIN 10 PLUS

Amino Acids (10% w/v) Injection with Electrolytes

200, 250, 500

CELEMIN 5S PLUS

Amino Acids (5% w/v) & Sorbitol (10% w/v) Injection
with Electrolytes

200, 500

CELEMIN Infant

Amino Acids (10 % w/v) Injection

500

200 ml200 ml^ Product Package Insert

Parenteral Amino Acids Solutions
CELEMIN HEPA

CELEMIN NEPHRO

Amino Acids (8% w/v) Injection ^Amino Acids (7% w/v) Injection ^Description• CELEMIN HEPA is a clear, colourless tofaintly yellow colored solution,
containing well balanced mixture ofpure crystalline, essential, semiessential and nonessential amino acids,
which are in optimum concentration forprotein synthesis.

• CELEMIN NEPHRO is a clear, colourless tofaintly yellow colored solution,
containing well balanced mixture orpure crystalline, essential, semiessential and non-essential amino acids,
which are in optimum concentration forprotein synthesis.

• The infusion could be given either by peripheral or central route by suitably adjusting
the flow rate.

Indications• For treatment of hepatic encephalopathy
in patients with cirrhosis / hepatitis.
• In hepatic coma.
• Nutrition support in patients withdiseases of liver who requires parenteralnutrition and are intolerant of general
purpose Amino acid solutions.

• Acute and chronic renal insufficiency,
in haemofiltration, peritoneal andhaemodialysis.
• For the compensation of amino acidlosses during and after dialysis or
haemofiltration.
• Renal failure following polytrauma,
extensive surgery and sepsis.
• Supplementing a low protein diet inchronic renal failure patients.

Composition
Brand Name

Description / Generic Name

CELEMIN HEPA 8%

Amino Acids (8% w/v) Injection

500

CELEMIN NEPHRO 7%

Amino Acids (7% w/v) Injection

250, 500^ Product Package Insert

Volume (ml)Intravenous Fat Emulsion
CELEPID / CELEPID MCT-LCTIntravenous Fat Emulsion/ Intravenous Fat Emulsion With Medium & Long Chain Triglycerides ^Description
CELEPID is a stable fat emulsion prepared from Soybean Oil, Egg Lecithin, Glycerol and Water for
Injection. CELEPID MCT-LCT is a stable fat emulsion prepared from Soybean Oil, MCT (Medium
Chain Triglycerides), Egg Lecithin and Glycerol.
Fat emulsions have the advantage of having high caloric yield. They are also isotonic with bloodand hence can be infused peripherally. The Soybean Oil of Celepid / Celepid MCT-LCT provides
essential fatty acids which help avoid essential fatty acid deficiency, its associated biochemicalchanges and clinical manifestations like scaly skin, growth retardation, sparse hair growth &delayed wound healing. A parenteral feeding regimen which contains Carbohydrates, Aminoacids and Fats provides a balanced metabolic load. Thus fat emulsions are indispensable unlessfats are contraindicated.
CELEPID MCT-LCT contains Medium Chain Triglycerides which are cleared from blood stream at afaster rate and are oxidized more completely for energy production than LCT(Long Chain
Triglycerides) and are not dependent upon biliary or pancreatic secretions for absorption fromgastrointestinal tract. In conditions where oxidation of LCT is impaired due to carnitine
deficiency, diminished carnitine palmitoyl transferase activity etc. MCT is preferential fuel in the
body over LCT.

Indications
CELEPID / CELEPID MCT-LCT provides energy in• Pre & Post operative nutritional disturbances • Cancer & associated Cachexia • Intravenous
nutrition in Burns • G.I. Tract diseases- Tumors, Peritonitis, Ulcerative colitis, Fistula, Shortbowel syndrome, Inflammatory bowel disease • Malabsorption • Impaired Renal Function• Prolonged unconciousness - Head injury, Poisoning

Composition
Brand Name

Description / Generic Name

Volume (ml)

CELEPID
MCT/LCT 10%

Intravenous Fat Emulsion with Medium &Long Chain Triglycerides (10% w/v)

250, 500

CELEPID
MCT/LCT 20%

Intravenous Fat Emulsion with Medium &Long Chain Triglycerides (20% w/v)

250, 500

CELEPID 10%

Intravenous Fat Emulsion (10% w/v)

100, 200, 250, 500

CELEPID 20%

Intravenous Fat Emulsion (20% w/v)

100, 250, 500

MCT-LCT: Medium Chain Triglycerides-Long Chain Triglycerides^ Product Package Insert

Enteral Nutrition
HINEX $
Description
A range of balanced enteral nutrition are developed for individuals & patients who are not able totake, digest or absorb normal food or who have special nutritional requirements as a results ofmetabolic disorders. HINEX contains specific nutrients, shown to be of benefit for the nutritional
management of disease conditions.
• HINEX HP is a vanilla flavoured advanced protein and nutritional supplement. HINEX HP
contains 100% high-quality protein (whey protein isolate) which promotes healing, recovery
from illness & build/ maintain lean body mass. It also contains 28 vitamins and minerals
which help to support bodily functions, improve musculoskeletal health and support
immunity.
• HINEX ST is a complete balanced nutrition with high-quality triple blend protein designed tohelp improve and maintain the nutritional status of patients.
• HINEX DM is a complete balanced nutritional supplement for patients with diabetes, and /or
hyperglycemic conditions.
• HINEX ST Plus is a complete balanced nutrition with synbiotics and high-quality triple blend
protein designed to help improve nutritional status & gut function.
$ : https://otsukapharma.in/product-category/enteral-nutrition

Indication
To be used for patients with normal gastrointestinal functioning requiring enteral nutrition forprevention / treatment of malnutrition and supporting recovery

Composition
Description / Generic Name

Volume (g)High protein nutritional supplement

400

HINEX ST

Standard nutritional supplement

400

HINEX ST Plus

Standard nutritional supplement with synbiotics

400

HINEX DM

Nutritional supplement for diabetic/hyperglycemic patients

400

Brand NameHINEX HP

Intravenous Fluids
Description*• Fluid and electrolyte abnormalities are common in critically ill patients and often represent
complications from underlying disease states or medication therapies. Critically ill patients
often experience alterations in absorption, distribution, and excretion of fluids andelectrolytes. Changes in hormonal and homeostatic processes and fluid status are also
common in intensive care unit patients.
• Significant complications can result from fluid and electrolyte abnormalities, and the severityof these complications usually parallels the magnitude of the disorder. Fluid and electrolyte
disorders occurring acutely and rapidly are often associated with increased symptoms andcomplications when compared to chronically occurring imbalances; these symptomaticabnormalities require more urgent treatment.

IV fluids and composition
Brand Name

Description / Generic Name

Volume (ml)NS

Sodium Chloride IV Infusion (0.9% w/v)

5, 10, 100, 250, 500, 1000

RL
DNS

Compound Sodium Lactate IV Infusion
Sodium Chloride and Glucose IV Infusion(0.9% w/v & 5% w/v)

100, 250, 500, 1000

10D

Glucose Intravenous Infusion (100 g/L)

100, 250, 500, 1000

20M

Mannitol IV Infusion (20% w/v)

5D
FLUSODEX

Glucose Intravenous Infusion (50 g/L)

100, 250, 500, 1000

Sodium Chloride and Glucose IV Infusion(0.45% w/v & 5% w/v)

500

100, 250, 500, 1000

100, 250, 500

PHYSIOMAXMultiple Electrolytes Injection Type-I

500, 1000

VITRINAL

100

HAFNOR

Sodium Chloride Infusion (3% w/v)
Sodium Chloride Infusion (0.45% w/v)

SWFI

Sterilised Water for Injections

5, 10

500

Container:
Nipple HeadEurohead (Flexidrip)

Non PVC Bag (Unibag)

Sterilised Water for
Injections* Billie Bartel etal.,Fluid and Electrolyte Management, Chapter 7: Fluid and Electrolyte Management, © Jones & Bartlett Learning, LLC.

Intravenous Fluids
NS Sodium Chloride Intravenous Infusion (0.9% w/v)^
The most frequently used solution is 0.9% Sodium Chloride
Solution which is isotonic to blood. It is indicated in:• Treatment of isotonic extracellular dehydrationand fluid replenishment• Treatment of sodium and chloride ions depletion• Vehicle or diluent of compatible drugs forparenteral administration

RL Compound Sodium Lactate Intravenous Infusion^Compound Sodium Lactate IV Inf. is a sterile, nonpyrogenic solution for fluid and electrolyte
replenishment in a single dose container for IV
administration. Indicated in:• Restoration of ECF and electrolytes balances orreplacement of ECF loss where isotonic concentrationsof electrolytes are sufficient• Short term volume replacement (alone or in association
with colloid) in case of hypovolemia or hypotension.

ECF: Extracellular fluid

DNS Sodium Chloride & Glucose Intravenous Infusion (0.9% w/v & 5% w/v)^
A combination of glucose and sodium chloride infusion
is used as a source of energy and for maintenance andreplacement of body fluid. It is indicated in:• Treatment of sodium depletion, extracellulardehydration or hypovolaemia in cases where supply ofwater and carbohydrates is required due to restrictionof the intake of fluids and electrolytes by normal routes.

10D Glucose Intravenous Infusion (100 g/L)

1,2

10% Dextrose Injection, is a clear, sterile, non-pyrogenic solution of dextrose insingle-dose container.
It is indicated in:• Supply of carbohydrate alone or, as required, during parenteral nutrition. • Prevention andtreatment of hypoglycaemia. • Rehydration in case of water loss and dehydration states inpatients with high carbohydrate need. • Dilution of compatible medicinal products.

20 M Mannitol IV Infusion (20% w/v)^
20% Mannitol Solution acts as a osmotic diuretic indicated in:• The promotion of diuresis, in the prevention and/or treatment of the oliguric phaseof acute renal failure before irreversible renal failure becomes established. The
reduction of intracranial pressure and treatment of cerebral edema by reducing brain
mass; The reduction of elevated intraocular pressure when the pressure can not belowered by other means, and Promoting the urinary excretion of toxic substances.
^ Product Package Insert

Intravenous Fluids
5D Glucose Intravenous Infusion (50 g/L)^
Glucose IV Infusion is a sterile, nonpyrogenic
solution for fluid, carbohydrate and caloric
supply in a single dose container for intravenous
administration. It is indicated for the treatmentof carbohydrate and fluid depletion. Also used asa vehicle and diluent for compatible medicinal
products for parenteral administration.

FLUSODEX Sodium Chloride and Glucose IV Infusion (0.45% w/v & 5% w/v)^
Flusodex provides water, sodium chloride andcarbohydrates. It is indicated in:• Treatment of dehydration or hypovolaemia incases where supply of water, sodium chloride andcarbohydrates is required due to restriction of theintake of fluids and electrolytes by normal routes.

PHYSIOMAX Multiple Electrolytes Injection Type I ^It is a crystalloid solution used for fluid replacementwith chemical composition as close as possible tothat of plasma. It is indicated in:• For fluid replacement (e.g. after burns, head injury,
fracture, infection, and peritoneal irritation)• As intraoperative fluid replacement• In hemorrhagic shock and clinical conditions
requiring rapid blood transfusions (compatibility
with blood)• In mild to moderate metabolic acidosis, also incase of lactate metabolism impairment.

VITRINAL Sodium Chloride 3% w/v Injection ^Sodium Chloride Injection (3% w/v) are indicated as a source of water andelectrolytes. They are capable of inducing diuresis depending on the clinicalcondition of the patient

HAFNOR Sodium Chloride Infusion (0.45% w/v)

1,20.45% Sodium Chloride Injection, solution is a sterile and nonpyrogenic solution
intended for intravenous administration.
It is indicated in the treatment of hypertonic extracellular dehydration or hypovolaemia
in cases where the intake of fluids and electrolytes by normal routes is not possible.
Ref: 1. https://www.drugs.com/pro/dextrose-injection-10.html 2.https://www.medicines.org.uk/emc/
product/1823/smpc#grefttps://www.medicines.org.uk/emc/product/1823/smpc#gref^ Product Package Insert

Anti-infectives
Ciprox Ciprofloxacin Injection (0.2% w/v)^
Ciprofloxacin is a second generation broad spectrum fluoroquinolone. It is active against both
Gram-positive and Gram-negative bacteria.*

Indications
It is indicated for the treatment of thefollowing infections caused by susceptible
bacteria:• Gastrointestinal infections• Severe systemic infections• Surgical infections• Respiratory tract infections• Urinary tract infections• Bone & joint infections• Skin & soft tissue infections• Gynecological infections

Metris Metronidazole Injection (0.5% w/v)^
Metronidazole is a nitroimidazole with antiprotozoal and antibacterial actions. It is highly
effective against Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. It has abactericidal action against pathogenic anaerobic bacteria, particularly Bacteroides spp. andFusobacterium spp.

Indications
1. Treatment of infections caused by Bacteroides fragilis and other species of Bacteroides like

Fusobacteria, Eubacteria and Anaerobic cocci such as• Intra abdominal infections• Gynaecological and obstetrical infections• Respiratory infections• Central nervous system infections• Miscellaneous infections-septicaemia,
gas gangrene, osteomyelitis.
2. Prevention of post operative infections due to anaerobic bacteria.
3. Treatment of amebic abscess of the liver and in moribund or toxic cases of fulminating intestinal.

OPLEV Levofloxacin Infusion I.V. 5 mg/ml^
Levofloxacin is a synthetic broad-spectrum, third-generation fluoroquinolone antibiotic used totreat bacterial infections.

Indications• Community-acquired pneumonia• Complicated skin and soft tissue infections• Pyelonephritis and complicated urinary
tract infections• Chronic bacterial prostatitis^ Product Package Insert* Front Pharmacol. 2017; 8: 546

Anti-infectives
Zofex Ofloxacin Infusion 2 mg/ml^• Ofloxacin is a second generation fluoroquinolone used for the treatment of mild-tomoderate bacterial infections• Has in-vitro activity against a broad spectrum of gram +ve and gram –ve aerobic andanaerobic bacteria.

Indications• Acute bacterial exacerbation of chronic bronchitis• Community-acquired pneumonia• Uncomplicated skin and skin structure infections• Acute, uncomplicated urethral and cervical gonorrohea• Nongonococcal urethritis and cervicitis• Mixed infection of urethra and cervix• Acute pelvic inflammatory disease• Uncomplicated cystitis

SYSZOL Fluconazole Infusion (2 mg/mL)^• The first of a new subclass of synthetic triazole antifungal agents, is available as a sterile
solution for intravenous use.

Indications
Treatment• Oropharyngeal and esophageal candidiasis.
• Cryptococcal meningitis.
Prophylaxis• To decrease the incidence of candidiasis in patients
undergoing bone marrow transplantation who receive
cytotoxic chemotherapy and/or radiation therapy.

Analgesic
Leniol Paracetamol Infusion (1% w/v)^
Paracetamol is the most widely used analgesic and antipyretic agent.

Indications• Short-term treatment of Fever.
• Short-term treatment of moderate pain, especiallyfollowing surgery.
Administration by intravenous route is justified whenother routes of administration is not possible or there isan urgent need to treat hyperthermia.

^ Product Package Insert

Disclaimer:
1. For Healthcare professional only
2. For more information kindly refer country specific pack insert
3. Licenses and licensing conditions may vary from country to country. Please always consult your country- specific prescribing information.
4. Product brand name (s) may be different country to country, kindly refer country specific artwork/ packinsert or local regulatory authority.
5. We are representing all possible SKUs (Strength, Volume & Containers), however kindly consult withlocal regulatory authority for availability of country specific SKUs.
6. Product image may be different than actual pack in the country.
7. Otsuka is a registered trademark of Otsuka Pharmaceutical Co., Ltd. Any other trademarks, Productbrands or images appearing herein are the property of their respective owners.

* As of December 31, 2021