消化器外科学講座【研究プロジェクト名および概要】
I.

消化管領域における研究
・ 食道癌手術後の呼吸器合併症減少を目指した革新的リスク評価法の確立
・ 胃 CMS 2/3 大腸癌に対する代謝関連蛋白阻害剤を用いた新規治療法の開発
・ 大腸癌に対する革新的治療戦略構築を目指した患者体組成に関する網羅的解析
・ 胃癌腹膜播種における腫瘍不均一性及び腫瘍微小環境を標的とした革新的治療法の開発
・ 遺伝性胃癌臨床検体の NGS 解析による新たな分子生物学的発癌メカニズムの解明
・ 大腸癌に対するがん免疫療法における革新的治療予測バイオマーカーの探索
・ 大腸癌の抗腫瘍免疫におけるニュートリエピジェネティクス
・ Fusobacterium が癌関連線維芽細胞と関連して消化器癌へ及ぼす影響のメカニズム解析
・ 革新的治療法開発を目指したサルコペニアと腫瘍免疫の統合的解析
・ F. nucleatum による大腸癌進展と鉄の関連

II.

肝・胆膵領域における研究・ 肝癌における C5aR と PD-L1 阻害剤との相互作用を介した革新的治療の開発
・ MYC と PGC1αが制御する癌代謝と腫瘍免疫を標的とした新規肝細胞癌治療法の開発
・ 新規免疫治療標的やバイオマーカー同定のための胃癌腹膜播種の動的免疫微小環境の解析
・ 糖・アミノ酸代謝シフトによる膵がん代謝制御機構の解明
・ がん - ストローマ代謝物クロストークによる膵癌進展メカニズムの解明
・ リキッドバイオプシーを用いた膵癌個別化治療のための腹膜播種予測 miRNA パネルの開発
・ アルコール性肝炎によるミトコンドリア PGAM5 を軸とした肝障害のメカニズム解明

III. 外科一般に関する研究
・ 消化器癌の発達・進展に関与する癌関連遺伝子の網羅的解析とバイオマーカー探索・ 消化器癌における腸内細菌叢の解明
・ 消化器癌におけるレトロトランスポゾンの解明
・ 癌代謝が消化器癌に及ぼす生理学的意義の解明
・ 消化器癌における癌関連繊維芽細胞の機能解明と制御, 癌との相互作用に関する研究【教職員･医員および大学院生】【メールアドレス】【研究プロジェクト】
准教授
宮本 裕士
miyamotoyuji@kumamoto-u.ac.jp
I, II, III (研究の統括)
特任准教授
馬場 祥史
y-baba@kumamoto-u.ac.jp
I,
III
特任准教授
岩槻 政晃
maiwa217@kumamoto-u.ac.jp
I,
III
講
師
林
洋光
hhayasi@kumamoto-u.ac.jp
II, III
診療講師
井田 智
sdaidaida@yahoo.co.jp
I,
III
診療講師
岡部 弘尚
hirohisaokabe1251@yahoo.co.jp
II, III
診療講師
日吉 幸晴
yukiharu0606@yahoo.co.jp
I,
III
特任助教
中川 茂樹
shigekn2@gmail.com
II, III
特任助教
江藤 弘二郎etouetouetou@yahoo.co.jp
I,
III
特任助教
小澄 敬祐
peugeolf_ksk_0930@yahoo.co.jp
I,
III
助
教
大内 繭子
mayuko030964@kumamoto-u.ac.jp
I,
III
特任助教
北野 雄希
beat11100411@yahoo.co.jp
II, III助教
伊東山 瑠美itoyama_rumi@yahoo.co.jp
II, III
救急助教
小川 克大
kogawa@kumamoto-u.ac.jp
I,
III
特任助教
問端 輔
t1293t@yahoo.co.jp
I,
III
医
員
原 淑大、高田 一登、安部 禎人、松本 将弥、大村 亮太、東 陽子、
高津 研翔、鈴木 裕紀子、式地 優樹、高橋 啓太、島本 将希
大学院生（4 年生） 小川 大輔、前田 裕斗、光浦 智証、湯本 信成、武 曦昱
大学院生（3 年生） 足立 優樹、金光 紘介、田尻 拓哉、堀野 大智、佟 依霖、王 懐涛、王 浩林
大学院生（2 年生） 耕 佳徹、谷崎 卓実、張 衛麗雲、董 翰宸、韓 錦濤、孫 宇軒
大学院生（1 年生） 椿原 拡樹、中村 尋、酒匂 照生、久野 祐樹
研 究 生
丁 銘、呉 霄漢、宋 銘洋【連絡先】 電話: 096-373-5212
Fax: 096-371-4378【ホームページ】http://kumamoto-gesurg.com/【特殊技術・装置】
臨床：食道・胃・大腸癌に対する完全鏡視下手術、腹腔鏡下 肝・膵切除、ダヴィンチ Si
特許：膵臓切離断端固定クリップ（特願 2019-050488）
基礎： DNA メチル化/遺伝子発現/代謝解析、遺伝子 Knock down/Overexpression、ゲノム編集（CRISPR-Cas9 system）、
切除検体由来癌関連線維芽細胞樹立、イメージング (BZ-X 蛍光顕微鏡, IncuCyte)、マウスモデル(移植：同所/異所,
allogenic/syngenic, 発がん)、FlowCytometry/CyToF を用いた single cell 解析および sorting、三次元培養システム

【英文論文】
1. Uemura N, Hayashi H, Liu Z, Matsumura K, Ogata Y, Yasuda N, Sato H, Shiraishi Y, Miyata T, Nakagawa S, MimaK, Nitta H, Baba H: Statins exert anti-growth effects by suppressing YAP/TAZ expressions via JNK signal activationand eliminate the immune suppression by downregulating PD-L1 expression in pancreatic cancer. Am J Cancer Res
13:2041-2054, 2023
2. Iwatsuki M, Matsumoto C, Mimori K, Baba H: The comprehensive review of gastric adenocarcinoma and proximal
polyposis of the stomach (GAPPS) from diagnosis and treatment. Ann Gastroenterol Surg 7:725-732, 2023
3. Kobayashi H, Kotake K, Kawasaki M, Kanemitsu Y, Kinugasa Y, Ueno H, Maeda K, Suto T, Itabashi M, Funahashi
K, Ozawa H, Koyama F, Noura S, Ishida H, Ohue M, Kiyomatsu T, Ishihara S, Koda K, Baba H, Kawada K, Hashiguchi
Y, Goi T, Toiyama Y, Tomita N, Sunami E, Akagi Y, Watanabe J, Hakamada K, Nakayama G, Sugihara K, Ajioka Y:
A proposed new Japanese classification of synchronous peritoneal metastases from colorectal cancer: A multiinstitutional, prospective, observational study conducted by the Japanese Society for Cancer of the Colon and Rectum.
Ann Gastroenterol Surg 7:765-771, 2023
4. Mima K, Nakagawa S, Miyata T, Yamashita YI, Baba H: Frailty and surgical outcomes in gastrointestinal cancer:
Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients. Ann Gastroenterol
Surg 7:27-41, 2023
5. Miyamoto Y, Ogawa K, Ohuchi M, Tokunaga R, Baba H: Emerging evidence of immunotherapy for colorectal cancer.
Ann Gastroenterol Surg 7:216-224, 2023
6. Nakamura I, Hatano E, Baba H, Kamei K, Wada H, Shimizu J, Kanai M, Yoshimura K, Nagano H, Ioka T: Impact ofconversion surgery after chemotherapy in patients with initially unresectable and recurrent biliary tract cancer. Ann
Gastroenterol Surg 7:1009-1020, 2023
7. Ichida A, Kokudo T, Shimada S, Hatano E, Kubo S, Kato Y, Ishikawa Y, Mori A, Baba H, Matsuyama Y, Endo I,
Yamaue H, Yamamoto M, Kokudo N, Hasegawa K: Liver resection for hepatocellular carcinoma with tumor thrombus
in the inferior vena cava or right atrium: A large-scale multicenter survey conducted in Japan. Ann Surg 278:e549e555, 2023
8. Zhao Y, Peng F, Wang C, Murano T, Baba H, Ikematsu H, Li W, Goel A: A DNA methylation-based epigenetic
signature for the identification of lymph node metastasis in T1 colorectal cancer. Ann Surg 277:655-663, 2023
9. Harada K, Matsumoto C, Toihata T, Kosumi K, Iwatsuki M, Baba Y, Ohuchi M, Eto K, Ogawa K, Sawayama H,
Iwagami S, Miyamoto Y, Yoshida N, Baba H: C-reactive protein levels after esophagectomy are associated withincreased surgical complications and poor prognosis in esophageal squamous cell carcinoma patients. Ann Surg Oncol
30:1554-1563, 2023
10. Ikenaga N, Miyasaka Y, Ohtsuka T, Nakata K, Adachi T, Eguchi S, Nishihara K, Inomata M, Kurahara H, Hisaka T,
Baba H, Nagano H, Ueki T, Noshiro H, Tokunaga S, Ishigami K, Nakamura M, Kyushu Study Group of treatment forpancreatobiliary C: A prospective multicenter phase II trial of neoadjuvant chemotherapy with Gemcitabine plus NabPaclitaxel for borderline resectable pancreatic cancer with arterial involvement. Ann Surg Oncol 30:193-202, 2023
11. Kitano Y, Inoue Y, Takeda T, Oba A, Ono Y, Sato T, Ito H, Ozaka M, Sasaki T, Sasahira N, Baba H, Takahashi Y:
Clinical efficacy of neoadjuvant chemotherapy with Gemcitabine plus S-1 for resectable pancreatic ductal
adenocarcinoma compared with upfront surgery. Ann Surg Oncol 30:5093-5102, 2023
12. Morinaga T, Iwatsuki M, Yamashita K, Yasuda-Yoshihara N, Yamane T, Matsumoto C, Harada K, Eto K, Kurashige
J, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Baba H: Dynamic alteration in HLA-E expression and soluble HLAE via interaction with natural killer cells in gastric cancer. Ann Surg Oncol 30:1240-1252, 2023
13. Morito A, Harada K, Iwatsuki M, Maeda Y, Mitsuura C, Toihata T, Kosumi K, Eto K, Iwagami S, Baba Y, Miyamoto
Y, Yoshida N, Baba H: Frailty Assessed by the Clinical Frailty Scale is Associated with Prognosis After
Esophagectomy. Ann Surg Oncol 30:3725-3732, 2023
14. Arima K, Uemura N, Tsuneyoshi K, Fujita H, Kuroki H, Uemura S, Hanada N, Baba H, Komohara Y: Microsatellite
instability-high signet ring cell carcinoma of the colon treated with immunotherapy: Report of a Case. Anticancer Res
43:4729-4733, 2023
15. Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T, Yanagida E, Murayama
T, Miyanari N, Baba H: Conversion surgery after Atezolizumab plus Bevacizumab for primary and peritoneal
metastasis after hepatocellular carcinoma rupture. Anticancer Res 43:943-947, 2023
16. Tomita M, Okabe H, Masuda T, Ono A, Kuroda D, Kuroki H, Hirota M, Hibi T, Baba H, Sugita H: A case of accessory
hepatic duct entering cystic duct successfully treated by laparoscopic cholecystectomy for cholecystolithiasis. Asian J
Endosc Surg 16:546-549, 2023
17. Tubakihara H, Sawayama H, Komohara Y, Miyamoto Y, Ogawa K, Ohuchi M, Yoshida N, Baba H: A case of familial
adenomatous polyposis with protein-losing enteropathy treated by laparoscopic total colorectal resection: A literature
review. Asian J Endosc Surg 16:77-81, 2023
18. Stachler MD, Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe M, Agoston A, Jajoo K, Davison
JM, Nason K, Getz G, Wang KK, Imamura Y, Odze R, Bass AJ, Zhang C-Z: Origins of cancer genome complexity
revealed by haplotype-resolved genomic analysis of evolution of Barrett’s esophagus to esophageal adenocarcinoma.
bioRxiv:2021.2003.2026.437288, 2023
19. Kosumi K, Baba Y, Yamamura K, Nomoto D, Okadome K, Yagi T, Toihata T, Kiyozumi Y, Harada K, Eto K,
Sawayama H, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H: Intratumour
Fusobacterium nucleatum and immune response to oesophageal cancer. Br J Cancer 128:1155-1165, 2023
20. Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima
K, Imai K, Baba H: Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes
epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer 128:844856, 2023
21. Saito Y, Fujiwara Y, Miyamoto Y, Ohnishi K, Nakashima Y, Tabata Y, Baba H, Komohara Y: CD169(+) sinus
macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer. Cancer
Med 12:10199-10211, 2023
22. Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T, Yamasaki J, Komohara Y,
Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K, Iwagami S, Tsukamoto H, Umemoto T, Masuda
M, Nagano O, Satou Y, Saya H, Tan P, Baba H, Ishimoto T: Stromal reprogramming through dual PDGFRalpha/beta
blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. Cancer Res 83:753-770, 2023
23. Liu Z, Hayashi H, Matsumura K, Uemura N, Shiraishi Y, Sato H, Baba H: Biological and clinical impacts of glucose
metabolism in pancreatic ductal adenocarcinoma. Cancers 15:498, 2023
24. Miyamoto Y, Akiyama T, Kato R, Sawayama H, Ogawa K, Yoshida N, Baba H: Prognostic significance of systemic
inflammation indices by K-ras status in patients with metastatic colorectal cancer. Dis Colon Rectum 66:e809-e817,

2023
25. Baba Y, Hara Y, Toihata T, Kosumi K, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Baba H:
Relationship between gut microbiome Fusobacterium nucleatum and LINE-1 methylation level in esophageal cancer.
Esophagus 20:704-712, 2023
26. Yoshida N, Eto K, Horinouchi T, Shiraishi S, Kanemitsu K, Ofuchi T, Tajiri T, Adachi Y, Horino T, Morito A, Mitsuura
C, Maeda Y, Hara Y, Matsumoto C, Baba H: Prognostic value of (18)F-fluorodeoxyglucose uptake in the bone marrowon pretreatment positron emission tomography/computed tomography in patients with esophageal cancer who
underwent esophagectomy. Esophagus 20:660-668, 2023
27. Shiraishi K, Nakaura T, Uetani H, Nagayama Y, Kidoh M, Kobayashi N, Morita K, Yamahita Y, Tanaka Y, Baba H,
Hirai T: Deep learning-based reconstruction and 3D hybrid profile order technique for MRCP at 3T: evaluation ofimage quality and acquisition time. Eur Radiol 33:7585-7594, 2023
28. Wei F, Uchihara T, Yonemura A, Yasuda-Yoshihara N, Yasuda T, Semba T, Fukuda M, Akiyama T, Kitamura F, Bu
L, Hu X, Fu L, Zhang J, Kariya R, Yamasaki J, Aihara K, Yamashita K, Nagano O, Okada S, Baba H, Ishimoto T: A
novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts. FEBS J 290:26042615, 2023
29. Yasuda T, Baba H, Ishimoto T: Cellular senescence in the tumor microenvironment and context-specific cancer
treatment strategies. FEBS J 290:1290-1302, 2023
30. Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F, Yasuda T, Semba T,
Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M, Komohara Y, Baba H, Ishimoto T: IL-1beta
derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting
microenvironment. Gastric Cancer 26:187-202, 2023
31. Fujiwara N, Kubota N, Zhu S, Nakagawa S, Baba H, Hoshida Y: Disseminative recurrence signature for hepatocellular
carcinoma from nonalcoholic fatty liver disease. Gastro hep advances 2:681-683, 2023
32. Maeda Y, Eto K, Yoshida N, Iwatsuki M, Iwagami S, Ogawa K, Sawayama H, Baba Y, Miyamoto Y, Baba H: The 5factor modified frailty index is a novel predictive marker of death from other diseases after curative gastrectomy for
gastric cancer. Geriatr Gerontol Int 23:750-756, 2023
33. Mima K, Hayashi H, Yumoto S, Matsumoto T, Tsukamoto M, Miyata T, Nakagawa S, Nitta H, Baba H: Disability inperioperative activities of daily living is associated with worse survival outcomes following hepatic resection in patientswith intrahepatic cholangiocarcinoma. Hepatol Res 53:135-144, 2023
34. Kawata A, Miyamoto Y, Fukubayashi K, Horio T, Miyamoto H, Ogawa K, Ouchi M, Tanaka Y, Baba H: Conversion
surgery after Encorafenib plus Cetuximab for chemorefractory BRAF V600E-mutated colorectal cancer with paraaortic lymph node metastases. In Vivo 37:1797-1801, 2023
35. Hirao H, Okabe H, Masuda T, Ogawa D, Uemura N, Kuroda D, Taki K, Tomiyasu S, Hirota M, Hibi T, Baba H, Sugita
H: Intestinal fluid CT level could predict pathological small bowel ischemia in small bowel obstruction. Indian J Surg
85:596-601, 2023
36. Omachi K, Imai K, Nakao Y, Nakamura H, Kaida T, Shiraishi Y, Itoyama R, Nitta H, Hayashi H, Asato T, Mikami Y,
Baba H: A surgical resection of hepatic granuloma mimicking intrahepatic cholangiocarcinoma: a case report. Int
Cancer Conf J 12:195-199, 2023
37. Horino T, Tokunaga R, Miyamoto Y, Hiyoshi Y, Akiyama T, Daitoku N, Sakamoto Y, Yoshida N, Baba H: The impactof the advanced lung cancer inflammation index on the outcomes of patients with metastatic colorectal cancer who
receive chemotherapy. Int J Clin Oncol 28:400-408, 2023
38. Kato R, Miyamoto Y, Ouchi M, Ogawa K, Yoshida N, Baba H: The Geriatric Nutritional Risk Index is a prognostic
marker in patients with metastatic colorectal cancer. Int J Clin Oncol 28:893-900, 2023
39. Kayashima H, Itoh S, Shimokawa M, Hayashi H, Takamori H, Fukuzawa K, Ninomiya M, Araki K, Yamashita YI,
Sugimachi K, Uchiyama H, Morine Y, Utsunomiya T, Uwagawa T, Maeda T, Baba H, Yoshizumi T: Effect of durationof adjuvant chemotherapy with S-1 (6 versus 12 months) for resected pancreatic cancer: the multicenter clinicalrandomized phase II postoperative adjuvant chemotherapy S-1 (PACS-1) trial. Int J Clin Oncol 28:1520-1529, 2023
40. Maehara Y, Oki E, Ota M, Harimoto N, Ando K, Nakanishi R, Kawazoe T, Fujimoto Y, Nonaka K, Kitao H, Iimori M,
Makino K, Takechi T, Sagara T, Miyadera K, Matsuoka K, Tsukihara H, Kataoka Y, Wakasa T, Ochiiwa H, Kamahori
Y, Tokunaga E, Saeki H, Yoshizumi T, Kakeji Y, Shirabe K, Baba H, Shimada M: Lineage of drug discovery researchon fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii. Int J Clin Oncol
28:613-624, 2023
41. Okui J, Shigeta K, Kato Y, Mizuno S, Sugiura K, Seo Y, Nakadai J, Baba H, Kikuchi H, Hirata A, Makino A, Kondo
T, Matsui S, Seishima R, Okabayashi K, Obara H, Sato Y, Kitagawa Y: Delayed-onset organ/space surgical site
infection worsens prognosis in high-risk stage II and III colorectal cancer. J Gastrointest Surg 27:2515-2525, 2023
42. Kanaka S, Matsuda A, Yamada T, Miyamoto Y, Yokoyama Y, Matsumoto S, Sonoda H, Ohta R, Shinji S, Sekiguchi
K, Baba H, Yoshida H: Segmental or right hemi-colectomy? The optimal surgical procedure for transverse coloncancer: a propensity score-matched, multicenter, retrospective study. Int J Colorectal Dis 38:58, 2023
43. Yoshida N, Eto K, Matsumoto T, Kosumi K, Imamura Y, Iwatsuki M, Baba Y, Miyamoto Y, Watanabe M, Baba H:
Omental flap wrapping around the esophagogastric anastomosis and association with anastomotic leak inesophagectomy for esophageal cancer: A propensity score-matching analysis. J Am Coll Surg 236:189-197, 2023
44. Ioka T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A, Takayama T, Yamaue H, Takahashi
M, Sho M, Kamei K, Fujimoto J, Toyoda M, Shimizu J, Goto T, Shindo Y, Yoshimura K, Hatano E, Nagano H, Kansai
Hepatobiliary Oncology G: Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin
for advanced biliary tract cancer (KHBO1401- MITSUBA). J Hepatobiliary Pancreat Sci 30:102-110, 2023
45. Akiyama T, Miyamoto Y, Matsuda A, Tokunaga R, Ogawa K, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Sonoda H,
Yamada T, Yoshida H, Baba H: The colon inflammatory index score can predict the survival outcome after resectionof colorectal cancer: a retrospective multicentre study. J Cancer Res Clin Oncol 149:7887-7894, 2023
46. Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, Yamashita K, Semba T, Arima K,
Uchihara T, Nishimura A, Bu L, Fu L, Wei F, Zhang J, Tong Y, Wang H, Iwamoto K, Fukuda T, Nakagawa H,
Taniguchi K, Miyamoto Y, Baba H, Ishimoto T: Downregulation of 15-PGDH enhances MASH-HCC development via
fatty acid-induced T-cell exhaustion. JHEP reports : innovation in hepatology 5:100892, 2023
47. Ijima H, Fukuda Y, Uehara MK, Shafiq M, Wu FQ, Cho JY, Sakai Y, Miyata T, Yamao T, Nakao Y, Kuroda Y,
Motomura T, Yamashita YI, Baba H: Decellularized mouse liver as a small-scale scaffold for the creation of aminiaturized human liver. J Chem Eng Jpn 56:1, 2023
48. Mima K, Baba H: Outcomes of patients with frailty and metastatic cancer admitted to the intensive care unit. Lancet
Healthy Longev 4:e655-e656, 2023
49. Imai K, Baba H: Initially unresectable colorectal liver metastases: the best therapeutic regimens. Lancet Oncol 24:711-

713, 2023
50. Maeda Y, Iwatsuki M, Mitsuura C, Morito A, Ohuchi M, Kosumi K, Eto K, Ogawa K, Baba Y, Iwagami S, Miyamoto
Y, Yoshida N, Baba H: Textbook outcome contributes to long-term prognosis in elderly colorectal cancer patients.
Langenbecks Arch Surg 408:245, 2023
51. Morito A, Iwatsuki M, Maeda Y, Mitsuura C, Hara Y, Matsumoto C, Toihata T, Kosumi K, Eto K, Baba Y, Iwagami
S, Miyamoto Y, Yoshida N, Baba H: Textbook outcome contributes to long-term prognosis in older adults with gastriccancer. Langenbecks Arch Surg 408:324, 2023
52. Ogawa K, Shiraishi Y, Karashima R, Nitta H, Masuda T, Matsumoto K, Sawayama H, Miyamoto Y, Baba H, Takamori
H: Prolonged door-to-antibiotics time is associated with high hospital mortality in patients with perforated colorectal
peritonitis. Langenbecks Arch Surg 408:220, 2023
53. Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe M, Agoston AT, Jajoo K, Davison JM, Nason
KS, Getz G, Wang KK, Imamura Y, Odze R, Bass AJ, Stachler MD, Zhang CZ: Genomic signatures of past and present
chromosomal instability in Barrett's esophagus and early esophageal adenocarcinoma. Nat Commun 14:6203, 2023
54. Shindo Y, Nagano H, Kanai M, Kobayashi S, Wada H, Sakai D, Eguchi H, Baba H, Kamachi H, Takayama T, Ueno
M, Takahashi M, Nakagami Y, Yoshimura K, Hatano E, Ioka T: Clinical outcomes of second‑line chemotherapy after
gemcitabine and cisplatin plus S‑1 treatment for patients with advanced biliary tract cancer in the KHBO1401‑3A study.
Oncol Rep 49:41, 2023
55. Kobayashi S, Wada H, Sakai D, Baba H, Kanai M, Kamachi H, Takayama T, Ueno M, Takahashi M, Sho M, Yoshimura
K, Hatano E, Nagano H, Ioka T: Impact of tumor shrinkage pattern with biweekly triplet gemcitabine+cisplatin+S-1
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