MMRC

Medical Mycology Research Center, Chiba University
千葉大学 真菌医学研究センター 概要

2013
  病
  原
  真
  菌
  研
  究
  を
  リ
  ｜
  ド
  す
  る

共同利用・共同研究拠点 真菌感染症研究拠点 
ナショナルバイオリソースプロジェクト 病原微生物 

目次 (Contents)

ページ（page）

はじめに (Preface) ···················································································································

2

沿革 (Historical Chart) ··············································································································

3

歴代所長・センター長 (Successive Directors) ·················································································

3

機構図 (Organization)················································································································

4

真菌症研究部門 (Department of Mycosis Research) 病原機能分野 (Division of Molecular Biology) ·············································································

5分子細胞シグナリング解析プロジェクト (Project for Molecular Signaling Analysis)
カンジダフェノームプロジェクト (Candida Phenome Project) 感染免疫分野 (Division of Molecular Immunology) ·······································································

8

感染応答プロジェクト (Project for Immune Response in Infectious Diseases)
サイトカインプロジェクト (Project for Cytokine Research)

臨床感染症分野 (Division of Clinical Research) ··········································································· 10
臨床感染症プロジェクト (Project to Link Basic Sciences and Clinical Researches) 微生物資源分野 (Division of Bio-resources) ················································································ 11
真菌・放線菌と宿主の分子相互作用研究プロジェクト(Project for Host Pathogen (fungi/actinomycetes) Molecular Interaction)
微生物創生プロジェクト (Project for Systems Biology of Microorganisms)
バイオリソース管理室 (Management Unit of Microbiological Resources)

ナショナル・バイオリソース・プロジェクト (National BioResource Project) ······································· 14
共同利用・共同研究拠点 (Joint Usage/Research Center) ································································ 15
共同利用・共同研究受入課題 (List of Joint Usage/Research Project) ·················································· 16
主要研究機器・設備について (Research Equipment and Facilities)···················································· 17
大学院における研究指導及び若手研究者の育成 (Promotion of the Young Investigators) ························ 19
真菌医学研究センター病原真菌講習会 (The Training Course of Pathogenic Fungi)································ 20
国際交流協定 (大学間交流協定・部局間交流協定など) (Inter-University and Faculty-level Exchange Agreements) ···· 21
国際的な共同研究員等及び学生の受入れ状況 (Number of International Joint Researchers and Students) ··· 21
長崎大学熱帯医学研究拠点特定領域共同研究 (Cooperative Research of Priority Areas with NEKKEN, Nagasaki University) ····· 22
地球規模課題対応国際科学技術協力事業 (Science and Technology Research Partnership for Sustainable Development) ······· 22
予算状況 (Budget) ···················································································································· 23
運営 (Administration)··············································································································· 24
アクセスマップ (Location and Access Map) ················································································· 251༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗 ≉௵ᩍᤵ ➲ᕝ ༓ᑜ
Director, MMRC   ࡣࡌࡵ࡟Professor Chihiro Sasakawa
Prefaceᡃࡀᅜ࡛ࡣࡍ࡛࡟㉸㧗㱋♫఍࡟✺ධࡋࠊࡲࡓ㧗ᗘ་⒪ࡸ⏕ά⩦័⑓࡟㉳ᅉࡋࡓ᪥࿴ぢឤᰁ⑕ࡶቑຍ
ࡢ୍㏵ࢆ㎺ࡾࠊ┿⳦ឤᰁ⑕ࡣ┈ࠎ኱ࡁ࡞ၥ㢟࡜࡞ࡗ࡚࠸ࡲࡍࠋࡲࡓୡ⏺ྛᆅ࡛ࡶ῝้࡞┿⳦⑕ࡀቑຍ
ࡍࡿ୍᪉ࠊඛ㐍ᅜ࡛ࡣ῝ᅾᛶ┿⳦⑕ࡀḟ➨࡟ቑຍࡋ࡚࠸ࡲࡍࠋࡉࡽ࡟ᾏእ࡜ࡢ஺ὶ࡟క࠸㞴἞ᛶࡢ㍺
ධ┿⳦⑕ࡶ᪂ࡓ࡞⬣ጾ࡜࡞ࡗ࡚࠸ࡲࡍࠋᅜẸࡢ㛫࡛ࡣࠊ᪂⯆࣭෌⯆ឤᰁ⑕ࡢ⬣ጾ࡜ࡋ࡚࢘࢖ࣝࢫࠊ⣽⳦ࠊཎ⹸࡬ࡢ㛵ᚰࡀ㞟ࡲࡾࡀࡕ࡛ࡍࡀࠊ┿⳦ࡢ⬣ጾࡶỴࡋ࡚┳㐣ࡍࡿࡇ࡜ࡣ࡛ࡁࡲࡏࢇࠋࡇࡢࡼ࠺࡞
⫼ᬒ࡛ࠊᡃࡀᅜ၏୍ࡢබⓗ࡞┿⳦་Ꮫ◊✲ᶵ㛵࡜ࡋ࡚ࠊᮏࢭࣥࢱ࣮ࡢ౑࿨ࡣ௨๓࡟ࡶቑࡋ࡚㔜せ࡟࡞ࡗ࡚࠸ࡲࡍࠋ ᮏࢭࣥࢱ࣮ࡣࠊ⑓ཎ┿⳦◊✲ࡢඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ࡜ࡋ࡚඲ᅜࡢ኱Ꮫࠊᅜබ❧◊✲ᶵ㛵ࠊ༓ⴥ኱Ꮫ㛵ಀ㒊ᒁࠊ་⒪ᶵ㛵ࠊ♫఍࡜⥭ᐦ࡟㐃ᦠࡋ࡚ࠊඹྠ฼⏝ࠊඹྠ◊✲ࠊᩍ⫱άືࢆ✚ᴟⓗ࡟⾜ࡗ࡚࠸ࡲࡍࠋࡲࡓᮏࢭࣥࢱ࣮࡛ࡣࠊ⑓ཎᚤ⏕≀ࡢࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ୰᰾
ⓗᣐⅬ࡜ࡋ࡚ࠊᮏ஦ᴗࢆ኱㜰኱Ꮫࠊ㛗ᓮ኱Ꮫࠊᒱ㜧኱Ꮫ࡜ศᢸࡋ࡚άືࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡉࡽ࡟ࡇࢀ
ࡽࡢ஦ᴗ࡜ᖹ⾜ࡋ࡚ࠊ⊂❧◊✲ࢢ࣮ࣝࣉ࣮ࣜࢲ࣮࡟ࡼࡿᇶ┙◊✲ࢆ᥎㐍ࡋ࡚࠸ࡲࡍࠋࡋࡓࡀࡗ࡚ᮏࢭ
ࣥࢱ࣮࡛ࡣࠊࠕඹྠ฼⏝࣭ඹྠ◊✲࣭ࣂ࢖࢜ࣜࢯ࣮ࢫᣐⅬ஦ᴗࠖ࡜ࠕᇶ┙◊✲ࠖࡢ஧ࡘࢆ୧㍯࡜ࡋ࡚ࠊ௒ᚋࡶᡃࡀᅜࡢ┿⳦་ᏛࡢⓎᒎ࡟ඛᑟⓗ࡞ᙺ๭ࢆᯝࡓࡍᡤᏑ࡛ࡍࠋ
In facing super-aging society, the increase in compromised patients is recognized as a social
problem with the aged population, wide use of intensive medical care, and lifestyle diseases, where
fungal infectious diseases become a threat of the society. Further, as the dramatic increase inworldwide trade, severe fungal infectious diseases bringing from abroad becomes additional
concern to the society. Since our concern on infectious diseases have traditionally been dominatedby virus, bacteria, and parasites as compared by the diseases caused by fungi, the role of theMedical Mycology Research Center (MMRC) at Chiba University becomes increasingly important.
In this context, as a joint Usage/Research Center, MMRC has been actively engaged in promoting
joint research of medical mycology and its related educational activities by cooperating with
universities, public institutions, medical institutions, and Chiba University. MMRC has also beenleading to the field of pathogenic microbes as a member of National BioResource Project (NBRP) in
Japan under the cooperation with the University of Osaka, Nagasaki University, and Gifu
University, where MMRC plays the central role as the key institution since 2002. Concurrently
MMRC is enthusiastic to strengthen the basis of fungal resource and promote the individual
research activities of fungal pathogenesis and host innate immune response. We therefore pursue
a vision to achieve top-level scientific research of medical mycology and resources of pathogenic
fungi and actinomycetales, through which we wish to act as the leading institution for thedevelopment of medical mycology.

 

㻌
㻌
㻞

2





ἢ㠉
Historical Chart᫛࿴  ᖺ  ᭶  ᪥ ༓ⴥ་⛉኱Ꮫ㝃ᒓ⭉ᩋ◊✲ᡤࡀタ❧ࡉࢀࡓ㸦⌧ᅾࡢ⩦ᚿ㔝ᕷ࿴Ἠ⏫㸧ࠋ  The Institute of Food-Microbiology Chiba Medical College was established.
᫛࿴  ᖺ  ᭶  ᪥ ༓ⴥ኱Ꮫ⭉ᩋ◊✲ᡤ࡜࡞ࡗࡓࠋ
    The Institute of Food-Microbiology was incorporated into the Chiba University.᫛࿴  ᖺ  ᭶  ᪥ ⏕≀άᛶ◊✲ᡤ࡟ᨵ⤌ࡉࢀࡓ㸦 ◊✲㒊㸧ࠋ  The Institute was reorganized to the Research Institute for Chemobiodynamics.
᫛࿴  ᖺ  ᭶  ᪥ ༓ⴥᕷ஻㰯  ୎┠  ␒  ྕ࡟᪂Ⴀࠊ⛣㌿ࡋࡓࠋ    The new building of the institute was built at 1-8-1 Inohana, Chiba-City.
᫛࿴  ᖺ  ᭶  ᪥ ⏕≀άᛶ◊✲ᡤࡀᗫṆ࣭㌿᥮࡜࡞ࡾࠊ඲ᅜඹྠ฼⏝᪋タ࡜ࡋ࡚┿᰾ᚤ⏕≀◊✲  
ࢭࣥࢱ࣮㸦 ◊✲㒊㛛  ศ㔝㸧ࡀタ⨨ࡉࢀࡓ㸦 ᖺ᫬㝈㸧ࠋThe Institute was reorganized to the Research Center for Pathogenic Fungi
and Microbial Toxicoses and became Nationwide Joint-use Facility.
ᖹᡂ  ᖺ  ᭶  ᪥ άᛶᛂ⟅◊✲㒊㛛࡟ࠊ᪂ࡓ࡟స⏝ᶵᵓศ㔝㸦ᐈဨ㸧ࡀタ⨨ࡉࢀࡓࠋ
  Division of Mechanisms of Biological Responses was newly founded.
ᖹᡂ  ᖺ  ᭶  ᪥ ┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮ࡀᗫṆ࣭㌿᥮࡜࡞ࡾࠊ඲ᅜඹྠ฼⏝᪋タ࡜ࡋ࡚┿⳦་ 
Ꮫ◊✲ࢭࣥࢱ࣮㸦 ◊✲㒊㛛  ศ㔝㸧ࡀタ⨨ࡉࢀࡓ㸦 ᖺ᫬㝈㸧ࠋThe center was reorganized to the Medical Mycology Research Center.
ᖹᡂ  ᖺ  ᭶  ᪥ ⑓ཎ┿⳦◊✲㒊㛛࡟ࠊ᪂ࡓ࡟┿⳦㈨※㛤Ⓨศ㔝ࡀタ⨨ࡉࢀࡓࠋ
  Division of Fungal Resources & Development was newly founded.
ᖹᡂ  ᖺ  ᭶  ᪥ᅜ❧኱Ꮫἲே࡟⛣⾜ࡋࡓࠋ   The Center was transformed into the National University Corporation.
ᖹᡂ  ᖺ  ᭶  ᪥ 㒊㛛  ศ㔝࡟ᨵ⤌ࡉࢀࡓࠋ
  The Center was reorganized into 1 department including 4 research divisions.
ᖹᡂ  ᖺ  ᭶  ᪥ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ ┿⳦ឤᰁ⑕◊✲ᣐⅬ ࡟ㄆᐃ  ᖺ㛫 ࡉࢀࡓࠋ
  The Center was certified for Joint Usage/Research Center (��years).

⭉ᩋ◊✲ᡤInstitute of Food-Microbiology⏕≀άᛶ◊✲ᡤResearch Institute for
Chemobiodynamics┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
Medical Mycology
Research CenterṔ௦ᡤ㛗࣭ࢭࣥࢱ࣮㛗
Successive Directors᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥ᑠụ ᩗ஦ Keizi Koike᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥┦☾ ࿴჆ Kazuyoshi Aiso᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥ᐑᮌ 㧗᫂ Komei Miyagi᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥┦☾ ࿴჆ Kazuyoshi Aiso᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥ᐑᮌ 㧗᫂Komei Miyagi᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥ᐑᮌ 㧗᫂Komei Miyagi⏕≀άᛶ◊✲ᡤ 㹼 
Research Institutefor᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥┦☾ ࿴჆Kazuyoshi Aiso
Chemobiodynamics
᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥᪂஭ ṇTadashi Arai᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥  ஂᡃ ဴᮁ Tetsuro Kuga᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥᪂஭ ṇ Tadashi Arai᫛࿴  ᖺ  ᭶  ᪥㹼᫛࿴  ᖺ  ᭶  ᪥ஂᡃ ဴᮁ Tetsuro Kugaᐑ἞ ㄔMakoto Miyaji┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮ 㹼  ᫛࿴  ᖺ  ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥
Research Center for Pathogenic
ᖹᡂ  ᖺ   ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶ ᪥ ᑎᑿ ΎKiyoshi Terao
Fungi and Microbial Toxicosesᖹᡂ  ᖺ   ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥ᐑ἞ ㄔMakoto Miyaji┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ 㹼 ᖹᡂ  ᖺ   ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥ᐑ἞ ㄔMakoto Miyaji
Medical Mycology Research Centerᖹᡂ  ᖺ  ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥  すᮧ ࿴ᏊKazuko Nishimuraᖹᡂ  ᖺ  ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥୕ୖ 〴Yuzuru Mikamiᖹᡂ  ᖺ  ᭶  ᪥㹼ᖹᡂ  ᖺ  ᭶  ᪥㔝ᮏ ᫂⏨Akio Nomotoᖹᡂ  ᖺ  ᭶  ᪥㹼➲ᕝ ༓ᑜ Chihiro Sasakawa⭉ᩋ◊✲ᡤ 㹼 Institute of Food-Microbiology





3

ᶵᵓᅗ㻌

Organization 㻌┿⳦⑕◊✲㒊㛛㻌
㻰㼑㼜㼍㼞㼠㼙㼑㼚㼠㻌㼛㼒㻌㻹㼥㼏㼛㼟㼕㼟㻌㻾㼑㼟㼑㼍㼞㼏㼔㻌䝉䞁䝍䞊㛗㻌
㻰㼕㼞㼑㼏㼠㼛㼞㻌ᩍဨ఍㆟㻌㻲㼍㼏㼡㼘㼠㼥㻌
㻹㼑㼑㼠㼕㼚㼓㻌
㐠Ⴀ༠㆟఍㻌
㻿㼏㼕㼑㼚㼠㼕㼒㼕㼏㻌㻯㼛㼡㼚㼏㼕㼘㻌

⑓ཎᶵ⬟ศ㔝㻌
㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻮㼕㼛㼘㼛㼓㼥㻌ศᏊ⣽⬊䝅䜾䝘䝸䞁䜾ゎᯒ䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻿㼕㼓㼚㼍㼘㼕㼚㼓㻌㻭㼚㼍㼘㼥㼟㼕㼟㻌䜹䞁䝆䝎䝣䜵䝜䞊䝮䝥䝻䝆䜵䜽䝖㻌㻯㼍㼚㼐㼕㼐㼍㻌㻼㼔㼑㼚㼛㼙㼑㻌 㻼㼞㼛㼖㼑㼏㼠㻌ឤᰁච␿ศ㔝㻌
㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻵㼙㼙㼡㼚㼛㼘㼛㼓㼥㻌ឤᰁᛂ⟅䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻵㼙㼙㼡㼚㼑㻌㻾㼑㼟㼜㼛㼚㼟㼑㻌㼕㼚㻌㻵㼚㼒㼑㼏㼠㼕㼛㼡㼟㻌㻰㼕㼟㼑㼍㼟㼑㼟㻌䝃䜲䝖䜹䜲䞁䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻯㼥㼠㼛㼗㼕㼚㼑㻌㻾㼑㼟㼑㼍㼞㼏㼔㻌⮫ᗋឤᰁ⑕ศ㔝㻌㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻯㼘㼕㼚㼕㼏㼍㼘㻌㻾㼑㼟㼑㼍㼞㼏㼔㻌⮫ᗋឤᰁ⑕䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼠㼛㻌㻸㼕㼚㼗㻌㻮㼍㼟㼕㼏㻌㻿㼏㼕㼑㼚㼏㼑㼟㻌㼍㼚㼐㻌㻯㼘㼕㼚㼕㼏㼍㼘㻌㻾㼑㼟㼑㼍㼞㼏㼔㼑㼟㻌ᚤ⏕≀㈨※ศ㔝㻌㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻮㼕㼛㻙㼞㼑㼟㼛㼡㼞㼏㼑㼟㻌┿⳦䞉ᨺ⥺⳦䛸ᐟ୺䛾ศᏊ┦஫స⏝◊✲䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻴㼛㼟㼠㻌㻼㼍㼠㼔㼛㼓㼑㼚㻌㻔㼒㼡㼚㼓㼕㻛㼍㼏㼠㼕㼚㼛㼙㼥㼏㼑㼠㼑㼟㻕㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻵㼚㼠㼑㼞㼍㼏㼠㼕㼛㼚㻌ᚤ⏕≀๰⏕䝥䝻䝆䜵䜽䝖㻌㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻿㼥㼟㼠㼑㼙㼟㻌㻮㼕㼛㼘㼛㼓㼥㻌㼛㼒㻌㻹㼕㼏㼞㼛㼛㼞㼓㼍㼚㼕㼟㼙㼟㻌䝞䜲䜸䝸䝋䞊䝇⟶⌮ᐊ㻌㻹㼍㼚㼍㼓㼑㼙㼑㼚㼠㻌㼁㼚㼕㼠㻌㼛㼒㻌㻹㼕㼏㼞㼛㼎㼕㼛㼘㼛㼓㼕㼏㼍㼘㻌㻾㼑㼟㼛㼡㼞㼏㼑㼟㻌㻠

4┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
⑓ཎᶵ⬟ศ㔝 (Division of Molecular Biology)ᕝᮏ 㐍 (ᩍᤵ࣭ศ㔝㛗࣭PI)
Susumu Kawamoto (Professor)
ᶓ὾ฟ㌟ࠋி㒔኱Ꮫ༞ᴗࠊி㒔኱Ꮫ኱Ꮫ㝔ᕤᏛ◊✲⛉(⏕໬Ꮫᑓᨷ)ಟ஢ࠋ༓ⴥ኱Ꮫ་Ꮫ㒊(➨஧⏕໬Ꮫᩍᐊ)ࠊ
⡿ᅜ Case Western Reserve University ་Ꮫ㒊ࠊᖇி኱Ꮫ་Ꮫ㒊ࠊᶓ὾ᕷ❧኱Ꮫ་Ꮫ㒊ࠊ⡿ᅜ University ofCalifornia-San Diego ་Ꮫ㒊ࢆ⤒࡚ 2004 ᖺࡼࡾ⌧⫋ࠋᶓ὾ᕷ❧኱Ꮫ་Ꮫ㒊(ᚤ⏕≀Ꮫᩍᐊ) ᐈဨᩍᤵࠋ

ศᏊ⣽⬊ࢩࢢࢼࣜࣥࢢゎᯒࣉࣟࢪ࢙ࢡࢺ
Project for Molecular Signaling Analysis

ࢡࣜࣉࢺࢥࢵࢡࢫࡢቚỒᰁⰍᴫせ (Abstract)⏕໬Ꮫ࣭ศᏊ⏕≀Ꮫ࣭⣽⬊⏕≀Ꮫ➼ࡢᡭἲࢆ⏝࠸ࠊ⑓ཎ㓝ẕ࣭⣒≧⳦ࡢศᏊ⣽⬊◊✲ࢆ⾜࠸ࠊ⑓ཎᶵ⬟࡞࡝࡟㛵㐃ࡍࡿࢩࢢࢼࣜࣥࢢゎᯒࢆ㐍ࡵࠊᢠ┿⳦⸆ࢩ࣮ࢬ๰ฟ࡞࡝┿⳦⑕ࡢศᏊไᚚ࡟ྥࡅࡓศᏊ⣽⬊་┿⳦Ꮫ࡬ࡢ㈉⊩ࢆ┠ᣦࡍࠋWe are conducting basic research on the molecular andcellular biology of pathogenic fungi using biochemistry andmolecular biology methods based on gene and proteinscience as well as ultrastructural morphology and cellbiology methods such as electron microscopy.

CnCln1/CnCdk1 (a-1, 2)ࠊ
CnCln1/ScCdk1 (b-1, 2) ࡢศᏊ㛫┦஫స⏝ゎᯒ୺࡞ࢸ࣮࣐ (Research Focus)⑓ཎ┿⳦ࡢ⣽⬊ᵓ㐀࣭⏕⌮ᶵ⬟ࢆ㑇ఏᏊ࣭ࢱࣥࣃࢡ㉁࡞࡝ศᏊ࡛ࣞ࣋ࣝࠊ᭦࡟ࡣ࢜ࣝ࢞ࢿࣛࣞ࣋ࣝࠊ⣽⬊࡛ࣞ࣋ࣝ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡟ࡋࡓศᏊ⣽⬊┿⳦་Ꮫࢆᚿྥࡋ࡚࠸ࡿࠋ㑇ఏᏊ࣭ࢱࣥࣃࢡ㉁⛉Ꮫࢆᇶ┙࡜ࡋࡓศᏊ⏕≀Ꮫ࣭⏕໬Ꮫⓗᡭἲ࠾ࡼࡧ㟁Ꮚ㢧ᚤ㙾࡞࡝⣽⬊Ꮫⓗ࣭ᚤ⣽ᙧែᏛⓗᡭἲ࡜ࢆ㍈࡟ࡋ࡚⑓ཎ┿⳦ࡢ⣽⬊࿘ᮇไᚚᶵᵓࡸప㓟⣲⎔ቃࢫࢺࣞࢫᛂ⟅ᶵᵓゎᯒ࡞࡝ ࡟࢔ࣉ࣮ࣟࢳࡋ࡚࠸ࡿࠋ
Our group is involved in research on molecular and cellular medical mycology with the goal of deciphering
the molecular functions by elucidation of the cell structure and cell functions at the molecular level, throughanalysis of genes and proteins, and at the organelle and cellular level. We are approaching to themolecular and cellular mechanism of cell cycle regulation, hypoxia stress response of pathogenic fungi.
◊✲ࢫࢱࢵࣇ
(Staff)෸ᩍᤵᒣཱྀ ṇど
Associate Professor෸ᩍᤵᶓᒣ ⪔἞
Associate Professor ຓᩍΎỈ බᚨ
Assistant Professor ᢏ⾡⫋ဨ ኱ᴋ ⨾బᏊ
Research Technicianᐈဨᩍᤵ (ᮾி኱Ꮫྡ㄃ᩍᤵ)
ᮾỤ ᫛ኵ
Guest Professor≉௵ຓᩍⴗཎ ኱♸Research Assistant Professorᢏ⾡⿵బဨ୰㔝 ⓒᐇᏊ Research Promotion Technician㠀ᖖ໅ㅮᖌ
ᅬ⏣ ᬛᏊ
Visiting Lecturer㠀ᖖ໅ㅮᖌ 
Eric V Virtudazo Visiting Lecturer㠀ᖖ໅ㅮᖌ‶ᒣ 㡰୍
Visiting Lecturer㠀ᖖ໅ㅮᖌᮧᒣ ⍀᫂
Visiting Lecturer㠀ᖖ໅ㅮᖌ㧗ᶫ ἞⏨ Visiting Lecturer  Lab URL
http://www.pf.chiba-u.ac.jp/bunya_byougenkinou.html
5Masashi Yamaguchi
Koji Yokoyama      
Kiminori Shimizu
Misako Ohkusu   Akio Toh-e
Daisuke Hagiwara
Yumiko Nakano
Tomoko Sonoda
Eric V Virtudazo
Junichi Mitsuyama
Somei Murayama
Haruo Takahashiᒣཱྀ ṇど (෸ᩍᤵ)

Masashi Yamaguchi (Associate Professor)ᒣᙧ┴⏕ࡲࢀࠋᒣᙧ኱Ꮫ༞ᴗᚋࠊᮾி㒔❧኱Ꮫ኱Ꮫ㝔ධᏛࠊ⌮Ꮫ༤ኈྕྲྀᚓࠋࢽ࣮࣮ࣗࣚࢡᕷ࣓ࣔࣜ࢔ࣝࢫ
࣮ࣟࣥࢣࢱࣜࣥࢢࡀࢇ◊✲ᡤࠊࣇ࢕ࣛࢹࣝࣇ࢕࢔ᕷࣔ
ࢿࣝ໬Ꮫឤぬ◊✲ᡤࠊᮾிឿᜨ఍་⛉኱Ꮫࢆ⤒࡚
1996 ᖺࡼࡾ⌧⫋ࠋ㟁Ꮚ㢧ᚤ㙾ࢆ⏝࠸ࡓᚤ⏕≀ࡢ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ᪥ᮏ㢧ᚤ㙾Ꮫ఍ᢏ⾡ຌປ㈹ࢆཷ㈹ࠋ
ᴫせཬࡧ◊✲ࢸ࣮࣐ (Abstract, Research Focus)1) ⑓ཎ┿⳦ࡢᚤ⣽ᙧែᏛⓗ◊✲㸦Ultrastructural Studies on Pathogenic Fungi㸧
2) 深海微生物の細胞構造から探る生物進化（Examining Evolution Through Cellular Structures of Deep-sea
Microorganisms）真核生物は、どのようにして原核生物から進化したかなど、生物進化のメカニズムに関しては、まだまだ不明のことが多い。深海には、10～30 億年前の微生物が今も生きている可能性があり、そのような微生物の細胞構造、DNA などを調べることによって、進化の重要な手がかりを得ることができると期待される。実際われわれは、2012 年、原核生物から真核生物への進化の途上にあると考えられる生物を発見し、「准核生物」と命名した。

ᶓᒣ ⪔἞ (෸ᩍᤵ)

Koji Yokoyama (Associate Professor)⚟ᓥᕷ⏕ࡲࢀࠊ᪂₲኱Ꮫ኱Ꮫ㝔㸦㎰Ꮫ◊✲⛉㸸ಟኈ㸧ࠊ་Ꮫ༤ኈ㸦༓ⴥ኱Ꮫ㸧ࠋ⏕≀άᛶ◊✲ᡤࠊ┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮ࠊ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ࢆṔ௵ࠋᴫせཬࡧ◊✲ࢸ࣮࣐ (Abstract, Research Focus)1) ᙧែᙧᡂ㸦Morphogenesis㸧
Candida albicans ࡢ஧ᙧᛶ㸸ᙧែኚ᥮࣓࢝ࢽࢬ࣒ࠊᙧែኚ᥮࡟࠾ࡅࡿ⣽⬊㦵᱁ࡢືែゎᯒ2) ┿⳦ࡢ㐍໬㸦Fungal Evolution㸧ࢳࢺࢡ࣮࣒ࣟ b 㑇ఏᏊཬࡧ࣑ࢺࢥࣥࢻࣜ࢔඲㑇ఏᏊゎᯒ࡟ࡼࡿ┿⳦ࡢ㐍໬࡜⣔⤫㐍໬ࡢ◊✲3) ࣐࢖ࢥࢺ࢟ࢩࣥ࡟㛵ࡍࡿ◊✲㸦Mycotoxicology㸧㯮㯜⳦ཬࡧ Aspergillus niger ࡢ㑇ఏᏊศ㢮࡜࣐࢖ࢥࢺ࢟ࢩࣥ⏘⏕ᛶࡢ◊✲ᮾỤ ᫛ኵ (ᐈဨᩍᤵ)Akio Toh-e (Guest Professor)ᮾி㒔⏕ࡲࢀࠊᮾி኱Ꮫ኱Ꮫ㝔⌮Ꮫ⣔◊✲⛉ࠊ⌮Ꮫ༤ኈࠊ኱㜰኱ᏛᕤᏛ㒊ࠊᗈᓥ኱ᏛᕤᏛ㒊ࢆ⤒࡚ᖹᡂ 18ᖺ ᮾி኱Ꮫ኱Ꮫ㝔೵ᖺ㏥⫋㸦ྡ㄃ᩍᤵ㸧ࡲ࡛ࣃࣥ㓝ẕࡢศᏊ㑇ఏᏛ◊✲ࠊᖹᡂ 21ࠥ⌧ᅾ ༓ⴥ኱Ꮫ┿⳦་Ꮫ ◊ ✲ ࢭ ࣥ ࢱ ࣮ ࡛ ⑓ ཎ ᛶ 㓝 ẕ Cryptococcus
neoformans ࡢ㑇ఏᏛ◊✲࡟ᚑ஦ࠋᴫせཬࡧ◊✲ࢸ࣮࣐ (Abstract, Research Focus)⑓ཎᛶ㓝ẕ Cryptococcus neoformans ࢆࣔࢹࣝ⏕≀࡜ࡋ࡚ᇶ♏⏕≀Ꮫࢆ῝ࡵࠊ┿⳦་Ꮫ࡬ࡢ㈉⊩ࢆ┠ᣦࡍࠋ1) C. neoformans ࡟࠾ࡅࡿࣜࣥ㓟௦ㅰ㸦Phosphate Metabolism in C. neoformans㸧2) ᢠ┿⳦๣ࡢࢩ࣮ࢬ᥈⣴ࡢࡓࡵࡢ⏕ྜᛶ⤒㊰ࡢ◊✲ a.◲㯤௦ㅰ⣔ࠊb.ࣆ࣑ࣜࢪࣥ⏕ྜᛶ⤒㊰ࠋ㸦Biosynthetic
Pathway as a Source of Anti-fungal Agents (a) Sulfate Metabolism, (b) Pyrimidine Pathway）
3) C. neoformans ࣑ࢺࢥࣥࢻࣜ࢔ࡢ∦ぶ㑇ఏࡢศᏊᶵᵓࡢゎ᫂ (ி㒔኱Ꮫ኱Ꮫ㝔 すᮧᬛᶞ༤ኈ࡜ࡢඹྠ◊✲)㸦Mechanism of Uniparental Inheritance of C. neoformans Mitochondria㸧 (Collaboration with Dr.
Tomoki Nishimura, Kyoto University)6┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ⑓ཎᶵ⬟ศ㔝 (Division of Molecular Biology)▱ⰼ ༤἞ (෸ᩍᤵ࣭PI)
Hiroji Chibana (Associate Professor)Ἀ⦖┴⏕ࡲࢀࠋ⌰⌫኱Ꮫ༞ᴗࠊྠ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ಟኈㄢ⛬ಟ஢ࠊྡྂᒇ኱Ꮫ་Ꮫ◊✲⛉༤ኈㄢ⛬㸦་┿⳦Ꮫᑓᨷ㸧ಟ஢࡞ࡽࡧ࡟༤ኈ(་Ꮫ)ྲྀᚓࠋ௨ᚋࠊ⡿ᅜ࣑ࢿࢯࢱᕞ❧኱ᏛศᏊ㑇ఏᏛ⛉࣏ࢫࢻࢡࢆ⤒࡚
2001 ᖺᗘࡼࡾ⌧⫋ࠋ⑓ཎᛶ㓝ẕ Candida glabrata ࡢ⥙⨶ⓗ㑇ఏᏊᶵ⬟ゎᯒࢆ୰ᚰ࡟◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ

࢝ࣥࢪࢲࣇ࢙ࣀ࣮࣒ࣉࣟࢪ࢙ࢡࢺ

Candida Phenome Projectᴫせ (Abstract)
Candida ᒓ┿⳦ࡢ࠺ࡕ C. glabrata ࡣࠊC. albicans ࡟ḟ࠸࡛⮫ᗋศ㞳౛ࡢከ࠸⑓ཎ┿⳦࡛࠶ࡾࠊ㏆ᖺࠊ⮫ᗋୖၥ㢟࡜࡞ࡗ࡚ࡁࡓ non-albicans Candida ࡢ௦⾲✀࡛࠶ࡿࠋC. glabrata ࡣࠊ୍ಸయ⏕≀࡛࠶ࡿࡇ࡜ࡸ㉁ࡢ㧗࠸ࢤࣀ࣒᝟ሗࡀ࠶ࡿࡇ࡜ࠊࡉࡽ࡟㑇ఏᏊᩘࡀᑡ࡞࠸ࡇ࡜࠿ࡽࠊศᏊ⏕≀Ꮫⓗゎᯒࡀ⑓ཎ┿⳦ࡢ୰࡛᭱ࡶᐜ࡛᫆࠶ࡿࠋᡃࠎࡣࠊC. glabrata ࢆ⑓ཎ┿⳦ࡢࣔࢹࣝ⏕≀࡜ࡋ࡚ᤊ࠼ࠊ඲㑇ఏᏊ࡟ᑐࡍࡿ⤌᥮࠼యࣛ࢖ࣈ࣮ࣛࣜࢆᵓ⠏ࡋ࡚࠸ࡿࠋᮏࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸࡚ࠊឤᰁ࣓࢝ࢽࢬ࣒ࡢゎ᫂࡞ࡽࡧ࡟๪స⏝ࡀᑡ࡞ࡃᢠ⳦ࢫ࣌ࢡࢺ࣒ࣛࡢᗈ࠸ᢠ┿⳦⸆ࡢᶆⓗ᥈⣴ࢆ㐍ࡵ࡚࠸ࡿࠋࡲࡓࠊᮏࣛ࢖ࣈ࣮ࣛࣜࡣ඲ᅜ࠾ࡼࡧᾏእࡢ◊✲⪅࡜ඹྠ฼⏝ࡋࠊ◊✲ࢥ࣑ࣗࢽࢸ࢕
࣮ࡢⓎᒎ࡟ᐤ୚ࡍࡿࡶࡢ࡛࠶ࡿࠋ
In the genus Candida, C. glabrata is the second most frequently isolated species in clinical andrepresentative forms of non-albicans Candida. As C. glabrata is a haploid organism with high quality fullgenomic sequence data available and a relatively small number of genes, we consider this Yeast species anideal model for fungal pathogen research. Using this model species we have developed a highly efficient genetargeting system enabling high-throughput functional gene analysis. Our research aim is to modify all genes
in the C. glabrata genome in order to identify common virulence factors in fungi and novel antifungal drug
targets. We will share the genomic information and mutants with worldwide researchers.

୺࡞ࢸ࣮࣐ (Research Focus)1) ඲㑇ఏᏊ࡟ᑐࡍࡿయ⣔ⓗ⤌᥮࠼యࣛ࢖ࣈ࣮ࣛࣜࡢᵓ⠏2) 㑇ఏᏊ⤌᥮࠼యࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸ࡓ⑓ཎᅉᏊࡢ⥙⨶ⓗ◊✲3) 㑇ఏᏊ⤌᥮࠼ᰴࢆ⏝࠸ࡓᢠ┿⳦⸆ᶆⓗ᥈⣴1) Construction of systematically created mutants liberally
covering the entire genome
2) Comprehensive study for virulence factors using the mutant
library3) Study of anti-fungal drug targets using the mutant library◊✲ࢫࢱࢵࣇ
◊✲⿵ຓဨ
◊✲⿵ຓဨ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ

኱ᒾ ┿⌮┦⏣ ඃᏊ
Ᏹ㔝  ₶బ㔝 ᩥᏊ
᪂ぢ ୍ᫀሯཎ ṇಇ

(Staff)Technical AssistantTechnical Assistant
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer 
Lab URL
7

http://www.pf.chiba-u.ac.jp/bunya_byougenkinou.html

Mari Ohiwa
Yuko Aida
Jun UnoAyako Sano
Masakazu Niimi
Masatoshi Tsukahara┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ឤᰁච␿ศ㔝 (Division of Molecular Immunology)⡿ᒣ ගಇ (ᩍᤵ࣭ศ㔝㛗࣭PI)
Mitsutoshi Yoneyama (Professor)᪩✄⏣኱Ꮫ༞ᴗᚋࠊ኱㜰኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ಟ஢ࠋᮾி㒔⮫ᗋ་Ꮫ⥲ྜ◊✲ᡤ㸦⌧࣭ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸧ࠊி㒔኱Ꮫ࢘࢖ࣝࢫ◊✲ᡤࢆ⤒࡚ࠊ2010 ᖺࡼࡾ⌧⫋ࠋ ༓ⴥ኱Ꮫ༤ኈㄢ⛬ᩍ⫱࣮ࣜࢹ࢕ࣥࢢࣉࣟࢢ࣒ࣛ
ࠕච␿ࢩࢫࢸ࣒ㄪ⠇἞⒪Ꮫ᥎㐍࣮ࣜࢲ࣮㣴ᡂࣉࣟࢢࣛ
࣒ࠖࢥ࣮ࢫ࣮࣡ࢡᢸᙜࠋ

ឤᰁᛂ⟅ࣉࣟࢪ࢙ࢡࢺ
Project for Immune Response in Infectious Diseases
ᴫせ (Abstract) ឤᰁ࡟ᑐࡍࡿᡃࠎࡢ⏕య㜵ᚚࡣࠊ⮬↛ච␿࡜⋓ᚓච␿࡟ࡼࡗ࡚༠ㄪࡋ࡚⾜ࢃࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ≉࡟࢘࢖ࣝࢫឤᰁ࡟ᛂ⟅ࡋࡓ⮬↛ච␿ㄏᑟ࡟ὀ┠ࡋࠊឤᰁࢭࣥ
ࢧ࣮ศᏊ࡟ࡼࡿ࢘࢖ࣝࢫ⏤᮶ࡢ㠀⮬ᕫ᰾㓟᳨▱ࡢศᏊᶵᵓ
ࡢゎ᫂࡜ࠊࡑࢀ࡟ࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿච␿ᛂ⟅ࡢ⏕⌮ᶵ⬟ࢆゎᯒࡍࡿࡇ࡜࡟ࡼࡾࠊ࢘࢖ࣝࢫឤᰁ⑕࡟ᑐࡍࡿ᪂ࡓ࡞
἞⒪ᡓ␎ࡢ㛤Ⓨࢆ┠ᣦࡋࡓゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ
Innate immune system plays an essential role forself-defense against infection of a variety of pathogens.
In this project, we focus on antiviral innate immunity,
especially molecular machinery for detection of viral
infection and subsequent immune responses.
The
observations obtained from this study will help us toestablish a novel therapeutic or preventive strategy against infectious diseases by viruses.
୺࡞ࢸ࣮࣐ (Research Focus)1) ࢘࢖ࣝࢫࢭࣥࢧ࣮ RIG-I-like receptor (RLR)࡟ࡼࡿ࢘࢖ࣝࢫ⏤᮶㠀⮬ᕫ RNA ࡢㄆ㆑࡜ࡑࢀ࡟క࠺ࢩࢢࢼࣝ
άᛶ໬ࡢศᏊᶵᵓࡢゎᯒ2) RLR ࢆ௓ࡋࡓࢩࢢࢼࣝࡢ⏕⌮ᶵ⬟ࡢゎᯒ3) RLR ࢆᶆⓗ࡜ࡋࡓ᪂つᢠ࢘࢖ࣝࢫ⸆๣㛤Ⓨࢆ┠ᣦࡋࡓゎᯒ4) ᪂つឤᰁࢭࣥࢧ࣮ศᏊࡢ᥈⣴1) Molecular mechanism underlying detection of viral non-self RNA by RIG-like receptors (RLRs)
2) Analysis of physiological significance of RLR-mediated signaling
3) Studies on generation of novel antiviral drug candidate(s) targeting RLR system
4) Identification of novel sensor molecule(s) for detection of invading pathogens in innate immune system◊✲ࢫࢱࢵࣇຓᩍ≉௵◊✲ဨ㠀ᖖ໅ᢏ⾡⫋ဨ
ᢏ⾡⿵బဨ
ᢏ⾡⿵బဨ

ᑿ㔝ᮏ ᾈྖᖹ஭  ⋹Ꮚ⁪⃝  㤶௦Ꮚᖖ႐  ൲ᙪ⁪ἑ  ࡳࡺࡁ(Staff)Assistant Professor
Project Researcher
Adjunct Research Technician
Research Promotion Technician
Research Promotion Technician

Koji Onomoto
Reiko Hirai Kayoko Takizawa
Michihiko Jogi
Miyuki Takizawa

Lab URL http://www.pf.chiba-u.ac.jp/bunya_kansenmeneki/bunya_kansenmeneki/Mol._Immunol._jpn.html
8┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ឤᰁච␿ศ㔝 (Division of Molecular Immunology)すᇛ ᚸ (≉௵෸ᩍᤵ࣭PI)
Shinobu Saijo (Associate Professor)
2010 ᖺ 10 ᭶ࡼࡾ⌧⫋ࠋ๓௵ᆅࡢᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤ᫬௦࠿ࡽࠊಶయ࡛ࣞ࣋ࣝ⅖⑕ᛶ⑌ᝈⓎ⑕ᶵᵓࡢゎ᫂ࠊ⏕యᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

ࢧ࢖ࢺ࢝࢖ࣥࣉࣟࢪ࢙ࢡࢺ
Project for Cytokine Researchᴫせ (Abstract) ⏕యࡣࠊከ✀ከᵝ࡞⣽⬊ࡸ⤌⧊ࡀ஫࠸࡟᫬✵ⓗ࡟స⏝ࡍࡿࡇ࡜࡟ࡼࡾᜏᖖᛶࡀ⥔ᣢࡉࢀࡿ୍ࡘࢩࢫࢸ࣒࡛࠶ࡾࠊ
ࡑࡢ⥔ᣢ࡟࠾࠸࡚ࢧ࢖ࢺ࢝࢖ࣥࡣ୰ᚰⓗ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࠋከࡃࡢ⑌⑓ࡣ༢࡟୍ࡘࡢ⮚ჾࠊ⤌⧊ࡢ␗ᖖ࡛ࡣ࡞
ࡃࠊච␿⣔ࢆጞࡵ࡜ࡍࡿ✀ࠎࡢࢩࢫࢸ࣒ࡢ␗ᖖ࡛࠶ࡿࡇ࡜࠿ࡽࠊ
ࡇࢀࡽࢆ⤫ྜࡍࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࢆ▱ࡿࡇ࡜ࡣ㠀ᖖ࡟㔜せ࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊឤᰁᛶ⑌ᝈࡸ⅖⑕ᛶ⑌ᝈࡢ⑓ែ
ᙧᡂ࡟࠾ࡅࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࢆゎ᫂ࡋࠊ᭱⤊ⓗ࡟᪂ࡓ࡞἞⒪⸆ࡢᶆⓗศᏊࢆぢฟࡍࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
Cytokines play a central role in maintenance of
homeostasis. Development of transgenic techniques has
made it possible to directly analyze the functions of aparticular gene in a living animal. We aim to find newtherapeutic targets for inflammatory diseases and infectious
diseases by investigating the roles of cytokines inpathogenesis using transgenic techniques.
୺࡞ࢸ࣮࣐ (Research Focus) ࢧ࢖ࢺ࢝࢖ࣥࡢ⏘⏕ᶵᵓ࡜ࡑࡢ⏕⌮ᶵ⬟ࡢゎ᫂ࢆ┠ⓗ࡜ࡋࠊಶయ࡛ࣞ࣋ࣝࡢゎᯒࢆ⾜࠺ࠋ1) ࢧ࢖ࢺ࢝࢖ࣥ࡟ࡼࡿච␿ᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂2) ┿⳦࡟ࡼࡗ࡚ㄏᑟࡉࢀࡿࢧ࢖ࢺ࢝࢖ࣥ࡜ࡑࡢឤᰁ㜵ᚚ࡟࠾ࡅࡿᙺ๭ࡢゎ᫂3) ⮬ᕫච␿⑌ᝈࠊ࢔ࣞࣝࢠ࣮ᛶ⑌ᝈࡢ⑓ែᙧᡂ࡟࠾ࡅࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࡢゎ᫂
Using gene-deficient mice, we are investigating the mechanisms of cytokine production and their roles in thedevelopment of infectious and inflammatory diseases.
1) Elucidation of the roles of cytokines in the maintenance of immune homeostasis.
2) Elucidation of the roles of cytokines induced by fungal infection.
3) Elucidation of the roles of cytokines in the pathogenesis of inflammatory diseases.

◊✲ࢫࢱࢵࣇᢏ⾡⿵బဨᢏ⾡⿵బဨ᳃ᮏ 㞞Ꮚ㕥ᮌ ᬛ᫂

(Staff)Research Promotion Technician
Research Promotion Technician

Masako Morimoto
Tomoaki Suzuki

Lab URL http://www.pf.chiba-u.ac.jp/bunya_kansenmeneki/bunya_kansenmeneki/Mol._Immunol._jpn.html
9┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ⮫ᗋឤᰁ⑕ศ㔝 (Division of Clinical Research)ட஭ ඞᙪ (ᩍᤵ࣭ศ㔝㛗࣭PI)
Katsuhiko Kamei (Professor)ᮾி㒔ฟ㌟ࠋ༓ⴥ኱Ꮫ་Ꮫ㒊༞ᴗᚋࠊ㒔❧ᗓ୰⑓㝔ࠊබ❧᫛࿴⑓㝔࿧྾ჾ⛉ࢆ⤒࡚ࠊ༓ⴥ኱Ꮫ་Ꮫ㒊࿧྾ჾෆ⛉ຓᡭࠋ
Stanford ኱Ꮫ␃Ꮫᚋࠊ2003 ᖺᗘࡼࡾ⌧⫋ࠋ┿⳦ࡢឤᰁᶵᵓࡢほⅬ࠿ࡽ㺂┿⳦⑕ࡢデ᩿࣭἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋ

⮫ᗋឤᰁ⑕ࣉࣟࢪ࢙ࢡࢺ
Project to Link Basic Sciences and Clinical Researchesᴫせ (Abstract) ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࢆᙜ㠃ࡢ᭱኱ࡢ┠ᶆ࡜ࡋࡘࡘࠊ┿⳦ࡀ࡝࠺ࡸࡗ࡚ேయ࡟౵ධࡍࡿࡢ࠿࡜࠸࠺ほⅬ࠿ࡽ㺂᪂ࡋ࠸デ᩿ࡸ἞⒪ࡢ㛤Ⓨࢆ୰ᚰ࡟◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋࡲࡓࡇࢀ࡜୪⾜ࡋ࡚ࠊ㝃ᒓ⑓㝔࡟࠾ࡅࡿデ⒪άືཬࡧᏛෆእ࡛
ࡢࢥࣥࢧࣝࢸ࣮ࢩࣙࣥࢆ⾜࡞ࡗ࡚࠾ࡾࠊᏛእ࠿ࡽࡣ᳨ᰝࢆྵࡵ࡚ᖺ㛫 200-300 ௳࡟㐩ࡋ࡚࠸ࡿࠋ ᐇ᪋యไ㸸ᩍဨ 2 ྡ㸦㸩වົ 1 ྡ㸧ࠊᢏᐁ 1 ྡࠊ≉௵ຓᩍ 2 ྡࠊ⿵ຓဨ 3 ྡ࡛◊✲ཬࡧ኱Ꮫ㝔⏕ 4 ྡ㸦༤ኈㄢ⛬㸧ࡢᩍ⫱ᣦᑟࢆ⾜࡞ࡗ࡚࠸ࡿࠋ
Our research focuses on the development of diagnostic and therapeutic methods for intractable fungal
diseases, such as aspergillosis, through an investigation into the mechanisms of infection. We also care forpatients in the clinic of the University Hospital, while providing consulting services on fungal diseases tophysicians/clinical technologists all over the country of Japan.
STAFF: There are Professors (3, including 1 concurrent position), a technician (1), research assistantprofessors (2), and research assistants (3) working in our group, and we also have four graduate school
students working in our group.
୺࡞ࢸ࣮࣐ (Research Focus)1) ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࡢឤᰁᶵᵓ࣭⑓ែ㸦⑓ീ㸧ࡢゎ᫂2) 㞴἞ᛶ┿⳦⑕ࡢデ᩿࣭἞⒪ἲࡢ㛤Ⓨ3) ㍺ධ┿⳦⑕ࡢ␿Ꮫ
1) Investigation of the pathogenesis of Aspergillus spp., including their virulence factors.
2) Development of diagnostic & therapeutic methods for intractable deep-seated mycoses.
3) Epidemiological analysis of endemic (imported) mycoses.
◊✲ࢫࢱࢵࣇ
(Staff) ຓᩍ⏣ཱྀ ⱥ᫛
Assistant Professorຓᩍ㸦㝃ᒓ⑓㝔ව௵㸧 Ώ㑓  ဴ   Assistant Professor (concurrent position)ᢏ⾡⫋ဨ㙑⏣ 㡪Ꮚ
Research Technician≉௵ຓᩍᮧ㛗 ಖ᠇
Research Assistant Professor≉௵ຓᩍඵᑜ ┿ᕼ
Research Assistant Professorᢏ⾡⿵బဨ஭ୖ ிᏊ
Research Promotion Technician ᢏ⾡⿵బဨዟ  ᖾኵ
Research Promotion Technician ᢏ⾡⿵బဨ㛵  㔛ளResearch Promotion Technician㠀ᖖ໅ㅮᖌஂ⡿  ගVisiting Lecturer㠀ᖖ໅ㅮᖌ῰㇂ ࿴ಇ
Visiting Lecturer 㠀ᖖ໅ㅮᖌ
ᐑ㷂 ⩏⥅
Visiting Lecturer 㠀ᖖ໅ㅮᖌ㇏␃ Ꮥோ
Visiting Lecturer 
http://clinical-r.pf.chiba-u.jp/
Lab URL

Hideaki Taguchi
Akira Watanabe
Kyoko Yarita
Yasunori Muraosa
Maki Yahiro
Kyoko Inoue
Yukio Oku
Rio Seki
Hikaru Kume
Kazutoshi Shibuya
Yoshitsugu Miyazaki
Takahito Toyotome10┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources)஬ࣀ஭ ㏱ (ᩍᤵ࣭ศ㔝㛗࣭PI)
Tohru Gonoi (Professor)⚟ᓥ┴ฟ㌟ࠋᇸ⋢኱༞ࠋ㟁Ẽ⏕⌮Ꮫᡭἲ࡜ศᏊ⏕≀Ꮫⓗᡭἲ➼ࢆ⤌ࡳྜࢃࡏ့ங㢮ࡢ ATP ౫Ꮡᛶ K ࢳࣕࢿࣝ ࢖ࣥࢫࣜࣥࡢศἪ࡟㔜せ ࡢᵓ㐀ࢆศᏊ࡛ࣞ࣋ࣝ
ゎ᫂ࡋࡓᚋࠊ┿⳦࣭ᨺ⥺⳦ࡢ◊✲࡟ࢩࣇࢺࡋࡲࡋࡓࠋ
ࢤࣀ࣒࣭㑇ఏᏊࢆ࠸ࡌࡾ࡞ࡀࡽࠊឤᰁ⑕ࡢඞ᭹ࢆ┠ᣦࡍ࡜࡜ࡶ࡟ࠊᚤ⏕≀㈨※ࡢ᭷⏝ᛶࢆ㏣ồࡋ࡚࠸ࡲࡍࠋ

┿⳦࣭ᨺ⥺⳦࡜ᐟ୺ࡢศᏊ┦஫స⏝◊✲ࣉࣟࢪ࢙ࢡࢺ
Project for Host Pathogen (fungi/actinomycetes) Molecular Interactionᴫせ (Abstract)ᚤ⏕≀㈨※ศ㔝࡛ࡣࠊࣂ࢖࢜ࣜࢯ࣮ࢫ⟶⌮ᐊ࡜༠ຊࡋࠊ᪥ᮏᅜෆཬࡧᾏእࡢࣄࢺࡸື≀࡟⏤᮶ࡍࡿ⑓ཎ┿⳦࣭⑓ཎᨺ⥺⳦ࢆ཰㞟ࠊ⟶⌮ࠊศㆡࡋ࡚࠸ࡿࠋࡇࢀࡽࡢ⳦ᰴᩘࡣࠊ⌧ᅾ⣙ 2 ୓࡟㐩ࡍࡿࡀࠊ⳦ࡢ࣐࣮࣮࢝㑇ఏᏊࡸࢤࣀ࣒ࢆゎᯒࡋࠊࡲࡓ⸆๣ឤཷᛶࡸ㟁Ꮚ㢧ᚤ㙾࡟ࡼࡿᙧែほᐹࠊ஧ḟ௦ㅰ⏘≀ࡢゎᯒ࡞࡝ࢆ⾜࠸⳦ᰴ㈨※ࠊ㑇ఏᏊ㈨※࡜ࡋ࡚ࡢ௜ຍ౯್ࡢྥୖ࡟ດࡵ࡚࠸ࡿࠋࡑࡢ௚ࡢ◊✲ࢸ࣮࣐࡟ࡘ࠸࡚ࡣࠗ୺࡞ࢸ࣮࣐࠘ࢆཧ↷ࡋ࡚ୗࡉ࠸ࠋ
 In cooperation with Bio-Resource management office, we collect pathogenic fungi and actinomycetes inboth inside and outside of Japan. We identify pathogenic fungi and actinomycetes as a public service, andanalyze their phylogenetic relations. We store fungi and actinomycetes with the support of the National
BioResource Projects in Japan, and distribute them upon request. Currently we stock approximately 20, 000
strains. We analyze sequences of marker genes and genomes, drug-sensitivities, and observe fine structuresusing electron-microscopy, to enhance biodiversity values. Other projects are listed below.
୺࡞ࢸ࣮࣐ (Research Focus)1) ࣄࢺ࣭ື≀ࡢ⑓ཎ┿⳦࣭⑓ཎᨺ⥺⳦ࡢ཰㞟ࠊศ㢮ࠊ⣔⤫ゎᯒࠊ஧ḟ௦ㅰ⏘≀ࡢゎᯒࠊ⑓ཎᅉᏊゎᯒࠊ஧ḟ௦ㅰ⏘≀⏕ྜᡂ㑇ఏᏊࠊࢤࣀ࣒ࡢゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ
2) ┿⳦࣭ᨺ⥺⳦ࡢࣄࢺ࡬ࡢឤᰁᶵᵓࡢゎ᫂ࢆศᏊ⏕≀Ꮫⓗᡭἲࠊື≀ࣔࢹࣝࠊࢤࣀ࣒ゎᯒ࡞࡝ࢆ⏝࠸࡚⾜ࡗ࡚࠸ࡿࠋ≉࡟ࠊ㏆ᖺࡣࠊ⢾㙐࡜⢾㙐ཷᐜయࢆ௓ࡋࡓ⳦࡜ᐟ୺ࡢ┦஫స⏝ゎ᫂࡟ຊࢆධࢀ࡚࠸ࡿࠋ3) ┿⳦ឤᰁ⑕Ⓨ⑕࡜ᐟ୺ࡢᰤ㣴≧ែࡸࢫࢺࣞࢫ≧ែ࡜ࡢ㛵㐃ࢆື≀ࣔࢹࣝ࡞࡝ࢆ⏝࠸࡚◊✲ࡋ࡚࠸ࡿࠋ≉࡟௦ㅰ㛵㐃ศᏊ࡜ච␿㛵㐃ศᏊࡢᶵ⬟ⓗࣜࣥࢡ࡟⯆࿡ࢆᣢࡗ࡚࠸ࡿࠋ
1) We collect, identify and phylogenetically analyze of human and animal pathogenic fungi andactinomycetes. We also analyze second metabolites and their synthetic enzymes, pathogenic factors, andgenomes.
2) We analyze infection mechanisms of human pathogenic fungi and actinomycetes using molecularmethods, animal models, and genome analysis. In particular, we are trying to understand roles of cellsurface glycans and their receptors (lectins) of human and fungi in infection.
3) We study effects of diets and mental stresses on fungal infections mainly using animal models andmolecular methods. We are trying to clarify yet unknown links between metabolism and immune-related
molecules.
(Staff)◊✲ࢫࢱࢵࣇ
ຓᩍ኱Ⲩ⏣   ⣲ᏊAssistant Professor≉௵ຓᩍ㓇஭   㤶ዉỤResearch Assistant Professor≉௵ຓᩍ㧗ᶫ㸦୰ཱྀ㸧 ᱻ
Research Assistant Professorᢏ⾡⫋ဨᯇ⃝   ဴᏹ
Research Technicianᢏ⾡⿵బဨᕝྡ   ┤⨾Research Promotion Technician㠀ᖖ໅ㅮᖌ㕥ᮌ   ೺୍ᮁ
Visiting Lecturer
Lab URL  http://www.pf.chiba-u.ac.jp/bunya_biseibutsushigen.html
11

Motoko Oarada
Kanae Sakai
Azusa Takahashi-Nakaguchi
Tetsuhiro Matsuzawa
Naomi Kawana
Kenichiro Suzuki┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)  ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources)㧗ᶫ ᘯ႐ (෸ᩍᤵ࣭PI)
Hiroki Takahashi (Associate Professor)රᗜ┴⏕ࡲࢀࠋி㒔኱Ꮫ༞ᴗᚋࠊዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫ᝟ሗ⛉Ꮫ◊✲⛉ಟ஢ࠊ༤ኈ ⌮Ꮫ ྲྀᚓࠋዉⰋ
ඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫ᝟ሗ⛉Ꮫ◊✲⛉ຓᩍࢆ⤒࡚
2012 ᖺᗘࡼࡾ⌧⫋ࠋᚤ⏕≀๰⏕ࣉࣟࢪ࢙ࢡࢺ
Project for Systems Biology of Microorganisms
ᴫせ (Abstract) ᡃࠎࡣࢥࣥࣆ࣮ࣗࢱゎᯒ࡟ࡼࡗ࡚ࠊḟୡ௦ࢩ࣮ࢣࣥࢧ࣮
ࢆྵࡴᵝࠎ࡞⏕≀ᐇ㦂࡛ᚓࡽࢀࡿ኱㔞ࢹ࣮ࢱ࠿ࡽࡢ᪂つ⏕≀Ꮫⓗ▱ぢࡢ๰ฟࠊ୪ࡧ࡟ࠊᩘ⌮ࣔࢹࣝ࢔ࣉ࣮ࣟࢳ࡟ࡼࡿ
⏕࿨⌧㇟ࡢゎ᫂࡟ྲྀࡾ⤌ࢇ࡛࠸ࡲࡍࠋ኱㔞ࢹ࣮ࢱ࡟ࡼࡿ⏕࿨ࡢࠕᵓᡂせ⣲ࡢ⌮ゎࠖࠊᩘ⌮ࣔࢹࣝ࡟ࡼࡿࠕᣲືࡢ⌮ゎࠖ࡜࠸࠺஧ࡘࡢࢥࣥࢭࣉࢺࡢୗࠊ⑓ཎ┿⳦ࢆྵࡴᚤ⏕≀ࢆᑐ㇟࡟⣽⬊ᶵ⬟ࡢศᏊ࡛ࣞ࣋ࣝࡢ⌮ゎࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋ
Our research areas are Bioinformatics and Systems
Biology. Our Bioinformatics approach aims to deeply andclearly understand massive biological experiment data,e.g., sequence data by next generation sequencers.
Systems Biology aims to understand how biological systems work and help the experimental design mainly
by mathematical modelling approach.
୺࡞ࢸ࣮࣐ (Research Focus)1) ⑓ཎ┿⳦ Aspergillus fumigatus ࡢ⪏⇕ᛶࡢゎ᫂⑓ཎ┿⳦࡛࠶ࡿ࢔ࢫ࣌ࣝࢠࣝࢫᒓ┿⳦ A. fumigatus ࢆᑐ㇟࡟ࠊࢤࣀ࣒㓄ิ࣭㑇ఏᏊⓎ⌧ࡢ୧ഃ㠃࠿ࡽ࢔ࣉࣟ
࣮ࢳࡍࡿࡇ࡜࡛⪏⇕ᙧ㉁ࢆᨭ࠼ࡿศᏊᇶ┙ࢆゎ᫂ࡍࡿࠋ2) ᯤⲡ⳦㧗ᛶ⬟ᐟ୺⣽⬊ࡢໟᣓⓗ⌮ゎࢤࣀ࣒㡿ᇦࡀ኱ᖜ࡟Ḟኻࡋ࡚࠸ࡿᯤⲡ⳦ MGB874 ࡣࠊእ᮶ࢱࣥࣃࢡ㉁ࡢྜᡂࡀቑ㐍ࡉࢀࡿ࡜࠸࠺≀㉁⏕⏘࡟ᴟࡵ࡚᭷฼࡞ᙧ㉁ࢆ᭷ࡋ࡚࠸ࡿࠋࡇࡢ᭷⏝ᙧ㉁ࢆᨭ࠼ࡿ㌿෗ᶵᵓ࣭௦ㅰᶵᵓࡢࢩࢫࢸ࣒ⓗ⌮ゎࢆᐇ⌧ࡍࡿࠋ3) ኱⭠⳦࡟࠾ࡅࡿ㔠ᒓᜏᖖᛶ⥔ᣢᶵᵓࡢᩘ⌮ࣔࢹࣝ࢔ࣉ࣮ࣟࢳ࡟ࡼࡿゎ᫂኱⭠⳦ࡢள㖄௦ㅰᶵᵓࢆᑐ㇟࡟ࠊᚤศ᪉⛬ᘧ࡟ࡼࡿᩘ⌮ࣔࢹ࡛ࣝࢩࢫࢸ࣒ࢆグ㏙ࡋࠊ㧗⢭ᗘࡢࢩ࣑࣮ࣗࣞࢩ
ࣙࣥࢆᐇ⌧ࡍࡿࠋ4) ᨺ⥺⳦ࡢ඲ࢤࣀ࣒ゎᯒ⣙ 80 ᰴ࡟ཬࡪᨺ⥺⳦ࣀ࢝ࣝࢪ࢔ᒓࡢ඲ࢤࣀ࣒᝟ሗࢆ⏝࠸࡚ࠊ᪂つ᭷⏝໬ྜ≀ࡢ⏘⏕⬟ࢆண ࡍࡿࠋ1) Understanding of heat stress responses in A. fumigatus by multi-omics data
2) Elucidating of the molecular mechanisms of improved production in B. subtilis strain MGB874
3) Mathematical modelling approach of zinc ion regulation system in E. coli4) Prediction of novel secondary metabolites in Nocardia by comparative genomics◊✲ࢫࢱࢵࣇ
㠀ᖖ໅◊✲ဨ
 
Lab URLᴋᒇ 㝧Ꮚ

http://bioinfo.pf.chiba-u.jp,

㸦Staff㸧Visiting Researcher

Yoko Kusuya

https://www.facebook.com/chiba.takahashi.lab
12┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources)▮ཱྀ ㈗ᚿ

(෸ᩍᤵ࣭ᐊ㛗)

Takashi Yaguchi (Associate Professor)
1987 ᖺ᪩✄⏣኱Ꮫ኱Ꮫ㝔⌮ᕤᏛ◊✲⛉༤ኈ๓ᮇㄢ⛬ಟ஢ᚋࠊ᫂἞〇Ⳬ㸦ᰴ㸧ධ♫ࠊ1995 ᖺ᪩✄⏣኱Ꮫࡼࡾ༤ኈྕࢆཷ㡿ࠊ2003 ᖺ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮࣭ຓᩍᤵ࡜ࡋ࡚ᑵ௵ࠊ⌧ᅾ࡟⮳ࡿࠋ୺࡞ཷ㈹Ṕ㸸᪥ᮏ⳦Ꮫ఍⳦Ꮫ◊✲ዡບ㈹ (1996 ᖺ)ࠊ᪥ᮏ་┿⳦Ꮫ఍◊✲ዡບ㈹ (2009 ᖺ)ࠋ

ࣂ࢖࢜ࣜࢯ࣮ࢫ⟶⌮ᐊ
Management Unit of Microbiological Resourcesᴫせ㸦Abstract㸧⑓ཎ┿⳦࣭ᨺ⥺⳦ࡢࠕಖᏑ࣭⟶⌮࣭ᥦ౪ࠖయไࢆᩚഛࡋࠊ᭱᪂᝟ሗࡀ௜ຍࡉࢀࡓಙ
㢗࡛ࡁࡿ⳦ᰴࡢᥦ౪ࢆ㏻ࡌ࡚ࠊ┿⳦⑕࡞ࡽࡧ࡟ࡑࡢཎᅉ⳦ࡢ◊✲࣭ᩍ⫱ࡢᇶ┙ࢆᨭ᥼ࡋ࡚࠸ࡿࠋ
We are developing a system for preservation, management and distribution ofpathogenic fungi and actinomycetes. We support the base of research andeducation of mycoses and their pathogens in order to supply reliable strains thatare added new information.
୺࡞ࢸ࣮࣐㸦Research Focus㸧⳦ᰴ⟶⌮ࡢ୍⎔࡜ࡋ࡚ࠊ⑓ཎ┿⳦ࡢᙧែ࠾ࡼࡧ⣔⤫ゎᯒࠊ✀ෆከᆺ࠾ࡼࡧᇵ㣴⣔୪ࡧ࡟㠀ᇵ㣴⣔࡟࠾ࡅࡿ㎿㏿ྠᐃࡢ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡿࠋ୺せ࡞ࢸ࣮࣐ࡣ௨ୗࡢ࡜࠾ࡾ࡛࠶ࡿࠋ1) ⑓ཎᛶ Aspergillus ࠾ࡼࡧ㛵㐃⳦࡟࠾ࡅࡿᙧែ࠾ࡼࡧ⣔⤫ゎᯒ࡟ࡼࡿศ㢮Ꮫⓗ◊✲2) ⑓ཎᛶ Candida ᒓࡢศᏊ␿Ꮫⓗᡭἲ࡟ࡼࡿศ㢮Ꮫⓗ◊✲
We are also studying on morphological and phylogenetical analysis andintra-species polymorphism of fungal pathogens, and rapid identification in theculture or non-culture system. The main themes are following as:1) Studies on the classification of pathogenic Aspergillus spp. and related
species based on phenotypic and molecular characteristics.
2) Reexamination and genotyping of pathogenic Candida spp.
◊✲ࢫࢱࢵࣇ
ຓᩍ
ᢏ⾡⫋ဨ
ᢏ⾡⿵బဨ
ᢏ⾡⿵బဨ
㠀ᖖ໅ᢏ⾡⫋ဨ㠀ᖖ໅ㅮᖌ㻌
㠀ᖖ໅ㅮᖌ㻌
㠀ᖖ໅ㅮᖌ㻌
㠀ᖖ໅ㅮᖌ 
Lab URL
13(Staff)⏣୰ ⋹Ꮚ
Assistant Professorఀ⸨ ⣧Ꮚ
Research Technicianᑠᓥ 㝧Ꮚ
Research Promotion Technician㛗ᮧ ⏤⨾Research Promotion Technician▮⃝ ຾Ύ
Adjunct Research TechnicianᇼỤ ⩏୍      㻌 Visiting Lecturer㧗ᶫ ᐜᏊ      㻌 Visiting Lecturer✄⚟ ࿴ᏹ   㻌
Visiting LecturerΎỈ ⏤ᕭ
Visiting Lecturer

http://www.pf.chiba-u.ac.jp/bunya_biseibutsushigen.html

Reiko Tanaka
Junko Ito
Yoko Kojima
Yumi Osamura
Katsukiyo Yazawa
Yoshikazu Horie
Yoko Takahashi
Kazuhiro Inafuku
Yumi Shimizuࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ㸦1%53㸧⑓ཎᚤ⏕≀ (Pathogenic microbes)ᩥ㒊⛉Ꮫ┬࡛ࡣ 2002 ᖺᗘ࠿ࡽࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ㸦NBRP㸧ࢆ㛤ጞࡋࠊᅜࡀᡓ␎ⓗ࡟ᩚഛࡍࡿࡇ࡜ࡀ㔜せ࡞⏕≀㈨※࡟ࡘ࠸࡚య⣔ⓗ࡟཰㞟ࠊಖᏑࠊᥦ౪࡞࡝ࢆ⾜࠺ࡓࡵࡢయไࢆᩚഛࡋ࡚ࡁࡓࠋࡑࡢᚋ
5 ᖺࡈ࡜ࡢぢ┤ࡋࢆ⾜࠸ࠊ2012 ᖺᗘࡼࡾ➨ 3 ᮇࡀ㛤ጞࡉࢀࡓࠋ
NBRPࠗ⑓ཎᚤ⏕≀࠘୰᰾ᶵ㛵࡛࠶ࡿ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㸦⑓ཎ┿⳦࣭ᨺ⥺⳦㸧ࠊ኱㜰኱Ꮫᚤ⏕≀⑓◊✲ᡤ࠾ࡼࡧᒱ㜧኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉㸦⑓ཎ⣽⳦㸧࡜㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤ㸦⑓ཎᛶཎ⹸㸧ࡣࠊ┦஫ࡢᶵ㛵ࡢ㐃ᦠࢆᅗࡾࠊࡇࢀࡽࡢ⑓ཎᚤ⏕≀ᰴࡢ཰㞟࣭ಖᏑ࣭ᥦ౪యไࢆᩚഛࡋ࡚ࠊ㧗ᗘ᝟ሗࢆ㈿୚ࡋࡓಙ㢗࡛ࡁࡿ⑓ཎᚤ⏕≀ᰴ࡜ࡋ࡚ᥦ౪ࡋࠊឤᰁ⑕࡜⑓ཎయࡢᩍ⫱࣭◊✲ࢆࡍࡿேࠎࢆᨭ᥼ࡋ࡚࠸ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ௒ᚋ࠸࠿࡞ࡿឤᰁ⑕ࡀⓎ⏕ࡋ࡚ࡶᑐᛂ࡛ࡁࡿ⑓ཎᚤ⏕≀ࢥࣞࢡࢩࣙࣥࢆ┠ᣦࡋ࡚࠸ࡿࠋ
In FY2002, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) implemented the National
BioResource Project (NBRP) to construct the framework for systematic collection, preservation, and distribution ofbioresources, with a focus on those that required strategic development by the national government. After the reviewing the
NBRP every five years, in FY2012, the third phase has stared.
Chiba University’s Medical Mycology Research Center (MMRC) is the “NBRP Center” for pathogenic microorganism,and this project is carried out by MMRC (pathogenic fungi/actinomycetes), Osaka University’s Research Institute forMicrobial Diseases (pathogenic bacteria), Gifu University’s Graduate School of Medicine (pathogenic bacteria), andNagasaki University’s Institute of Tropical Medicine (pathogenic protozoa). Working together, they cooperate in various
efforts to support education and research pertaining to infectious diseases and pathogens. Specifically, they are developinga system for collection, preservation, and distribution of pathogenic microorganisms, and they supply reliable strains ofpathogenic microorganisms that are backed by high-level information.
The project aims to establish a reliable and sufficient at the collection to deal with infectious diseases carried by any
pathogenic microorganisms.
ಖᏑ 㸦ᰴᩘ㸧 
H21 ᖺᗘ
1,594
┿⳦
188
ᨺ⥺⳦

H22 ᖺᗘ
742
141

ᥦ౪ 㸦௳ᩘ㸦ᰴᩘ㸧㸧㻌
H21 ᖺᗘ
㻌㻌
45(828)┿⳦
7 (55)
ᨺ⥺⳦

H23 ᖺᗘ
1,295
150

H22 ᖺᗘ
159 (1,669)
10 (69)H24 ᖺᗘ
686
99

H23 ᖺᗘ
120 (1,856)
16 (108)⣼ィ
18,6492,276

H24 ᖺᗘ
153 (1,981)
16 (139)ᅗ  NBRPࠗ⑓ཎᚤ⏕≀࠘యไᅗ 
Lab URL

http://pathogenic.lab.nig.ac.jp/
14ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ
Joint Usage/Research Center ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ࡣࠊᖹᡂ 21 ᖺ࡟ᩥ㒊⛉Ꮫ኱⮧࠿ࡽඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ࡟ㄆᐃࡉࢀࡲࡋࡓࠋඹྠ฼
⏝࣭ඹྠ◊✲ᣐⅬ࡜ࡣࠊᩥ㒊⛉Ꮫ┬ࡀᖹᡂ 21 ᖺᗘ࠿ࡽ᪂ࡓ࡟㛤ጞࡋࡓㄆᐃไᗘ࡛࠶ࡾࠊᏛ⾡◊✲ࡢᇶ┙ᙉ໬࡜᪂ࡓ࡞◊✲ࡢᒎ㛤ࢆ┠ᣦࡋࠊࡇࢀࡲ࡛୺࡟ᅜ❧኱Ꮫࡢ඲ᅜඹྠ฼⏝ᆺࡢ㝃⨨◊✲ᡤࡸࢭࣥࢱ࣮ࢆ୰ᚰ࡟⾜ࢃࢀ࡚ࡁࡓඹྠ฼⏝࣭ඹྠ◊✲ࢆࠊᅜබ⚾❧኱Ꮫࢆၥࢃࡎ࡟⾜࠺యไࢆᩚഛࡍࡿࡓࡵࡢไᗘ࡛ࡍࠋᖹᡂ 25 ᖺ 4 ᭶⌧ᅾࠊ41 ኱Ꮫ㸦29 ᅜ❧኱Ꮫࠊ12 බ⚾❧኱Ꮫ㸧90 ࡢ᪋タࡀᣐⅬ࡜ࡋ࡚ㄆᐃࡉࢀ࡚࠸ࡲࡍࠋᮏࢭࣥࢱ࣮ࡣࠊࠗ┿⳦ឤᰁ⑕◊✲ᣐⅬ࠘࡜ࡋ࡚άືࢆ⾜ࡗ࡚࠸ࡲࡍࠋ ᮏࢭࣥࢱ࣮࡛ࡣࠊ┿⳦࣭ᨺ⥺⳦࡟ࡼࡿ㞴἞ᛶ⑌ᝈ◊✲࡜ࡑࡢᡂᯝ࡟ࡼࡿ♫఍㈉⊩ࢆ┠ⓗ࡟ࠊ┿⳦࣭ᨺ⥺⳦ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࢆඹྠ฼⏝ࡢᇶ┙࡜ࡋ࡚ᩚഛ࣭ά⏝ࡋࠊ⑓ཎ┿⳦࣭ᨺ⥺⳦ࡢᇶ♏◊✲࠾ࡼࡧࡑࢀࡽ࡟ࡼࡿឤᰁ⑕ࡢ
デ᩿ࠊ἞⒪ࠊண㜵ἲࠊᐟ୺ච␿ᛂ⟅࡞࡝ࡢ◊✲࡟࠾࠸࡚ࠊᅜෆእࡢᩍ⫱◊✲᪋タ࡜ࡢඹྠ◊✲ࢆ⾜࠸ࠊ㛵㐃ศ㔝ࡢேᮦࢆ⫱ᡂࡍࡿࡇ࡜ࢆ┠ᶆ࡜ࡋ࡚࠸ࡲࡍࠋࡇࢀࡽࡢ┠ⓗࢆ㐩ᡂࡍࡿࡓࡵ࡟ࠊᩥ㒊⛉Ꮫ┬࠾ࡼࡧ༓ⴥ኱Ꮫ࠿ࡽࡢ
ᨭ᥼ࢆཷࡅࠊཝ㑅ࡋࡓඹྠ฼⏝࣭ඹྠ◊✲࡟ᑐࡋ࡚◊✲㈝ࢆ㓄ศࡍࡿ࡜࡜ࡶ࡟ࠊ㛵㐃ࡍࡿ◊✲఍ࡢ㛤ദࢆᨭ᥼ࡋ
࡚࠸ࡲࡍࠋ ᑐ㇟࡜࡞ࡿඹྠ฼⏝࣭ඹྠ◊✲ㄢ㢟࠾ࡼࡧ◊✲఍ࡣࠊẖᖺ 11 ᭶࡟඲ᅜ࡟බເࡋࠊ㛵㐃ࢥ࣑ࣗࢽࢸ࢕࡟ᒓࡍࡿ
እ㒊ࡢᑓ㛛ᐙࢆጤဨ࡜ࡍࡿ㐠Ⴀ༠㆟఍࡟࠾࠸࡚༠㆟ࡋࡓ࠺࠼࡛ࠊ᥇ᢥࡋ࡚࠸ࡲࡍࠋᖹᡂ 26 ᖺᗘࡢබເෆᐜ࡟ࡘ
࠸࡚ࡣࠊ㛵ಀࡍࡿ◊✲ᶵ㛵࡟㒑㏦ࡍࡿ࡜ྠ᫬࡟ࠊᮏࢭࣥࢱ࣮࣮࣒࣮࣍࣌ࢪ࡟බ㛤ࡍࡿணᐃ࡛ࡍࠋබເせ㡿ࢆࡈ☜ㄆࡋ࡚࠸ࡓࡔࡁࠊᮏࢭࣥࢱ࣮ࡢᩍဨ࡜ࡈ┦ㄯࡢ࠺࠼ࠊ✚ᴟⓗ࡟ᛂເࡋ࡚࠸ࡓࡔࡃࡼ࠺࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
 MMRC was certified as “Joint Usage/Research Center” by the Minister of Education, Culture, Sports, Science andTechnology in Japan (MEXT) in 2010. The aims of MMRC as Joint Usage/Research Center are; 1) Promotion ofcollaborative research with the research groups in other institutes, 2) Effective usage of the facilities of MMRC including
bio-resources of fungi and actinomycetes and 3) Development of human resources for the community of mycology
research.

㸺ඹྠ฼⏝࣭ඹྠ◊✲ࢆ⾜ࡗ࡚࠸ࡿᅜෆࡢ୺࡞◊✲ᶵ㛵㸼

15

平成年度共同利用・共同研究受入課題
List of Joint Usage/Research Project in 2013
研

1R



究

課

新規抗真菌薬開発を目指したアスペルギルス属糸状菌の薬剤耐性機構とシグナル伝達機構の解析

Molecular mechanisms of drug-resistance and signal transduction in Aspergilli and theirapplication to development of new antifungal drugs

Cryptococcus neoformans の特異なゲノム安定化機構の分子基盤
 -それを標的とした新規治療戦略を目指して-

Molecular basis for specific regulation of genome integrity in Cryptococcus neoformans and its
application to the development of novel therapeutic strategies







病原真菌における一酸化窒素(NO)の生成機構と生理的役割の解明
Synthetic mechanism and physiological role of nitric oxide (NO) in pathogenic yeast

Principal Researcher

東北大学大学院農学研究科

Graduate School of Argicultural Science,
Tohoku University

Graduate School of Advanced Integration
Science, Chiba University

奈良先端科学技術大学院大学
バイオサイエンス研究科

Graduate School of Biological Sciences,
Nara Institute of Science and Technolog

東京農工大学大学院

病原性を有するAspergillus niger  及び醸造黒麹菌のアレルゲン遺伝子の検索

国立医薬品食品衛生研究所

Discovery of novel antifungal proteins of mycoviruses and their application to develop new
antifungal drugs

Search of the allergen gene for phathogenic Aspergillus niger and a brewing Kuro-Koji molds

markers of mycosis

Schizophyllum commune による気管支喘息重症化メカニズムの解明
Deterioration of bronchial asthma caused by Schizophyllum commune

海洋生物を素材とした抗真菌剤の開発
 Research and development of new antifungal drugs from marine organisms

教授

阿部

敬悦

教授

松浦

彰

教授

高木

博史

准教授

森山

裕充

室長

鎌田

洋一

准教授

長

環

准教授

廣瀬

晃一

教授

小林

淳一

教授

川本

進

教授

五味

勝也

准教授

知花

博治

教授

岩倉

洋一郎

Professor

千葉大学大学院融合科学研究科

マイコウイルス由来新規抗菌性タンパク質の単離とそれを利用した抗病原性真菌剤の開発

病原真菌のmild heat stress 応答分子の探索と診断マーカーへの応用 Molecular research of mild heat stress response in pathogenic fungi and application of diagnostic



代 表 者

題

Title

Graduate School, Tokyo University ofAgriculture and Technology

Professor

Professor

Keietsu Abe

Akira Matsuura

Hiroshi Takagi

Associate Prof. Hiromitsu Moriyama

National Institute of Health Sciences

Head

福岡歯科大学

Fukuoka Dental College

Yoichi Kamata

Associate Prof. Tamaki Cho

千葉大学大学院医学研究院

Department of Molecular Genetics,
Graduate School of Medicine, Chiba
University

Associate Prof. Koichi Hirose

北海道大学大学院薬学研究院

Faculty of Pharmaceutical Sciences,
Hokkaido University

Professor

Jun’ichi Kobayashi

平成年度共同利用・共同研究受入課題
List of Joint Usage/Research Project in 2012
1R

研

究

課

代 表 者

題

Principal Researcher

Title

クリプトコックスの低酸素ストレス応答機構解析千葉大学真菌医学研究センター
 ～低酸素応答遺伝子として見出した「転写因子Ａ」の分子機能解析を中心として ～ MMRC
Hypoxia signaling analysis of Cryptococcus neoformans



新規抗真菌薬開発を目指したアスペルギルス属糸状菌の薬剤耐性機構とシグナル伝達機構の解析
Molecular analyses of mechanisms of drug resistance and signal transduction leading to novel
antifungal drug discovery in Aspergillus fungi

新規性の高い抗真菌薬標的の探索と阻害剤のアッセイ系の開発
 Search of novel antifungus targets and development of assay system for the repressor

東北大学大学院農学研究科

Graduate School of Argicultural Science,
Tohoku University

千葉大学真菌医学研究センター
MMRC

Professor

Professor

Susumu Kawamoto

Katsuya Gomi

Associate Prof. Hiroji Chibana

東京大学医科学研究所


真菌感染防御におけるIL-17産生機構に関する研究
Elucidation of IL-17 producing mechanisms with fungal infections

Center for Experimental Medicine,
The institute of Medical Science, The
University of Tokyo

Professor

Yoichiro Iwakura

東京大学医科学研究所
真菌性肺炎の発症機序の解明
 Molecular mechanisms of pneumonia induced by fungi

真菌による重症喘息発症機構の解明:Schizophyllum commune 応答を中心としてDeterioration mechanism of bronchial asthma focusing on its relation to Schizophyllum commune

病原性担子菌酵母糖タンパク質糖鎖の構造解析
 Structural analysis of sugars in the cell wall glycoproteins from pathogenic basidiomycete yeasts

リボソームタンパク質をバイオマーカーとした質量分析法による真菌の同定・分類法の開発

Frontier Research Initiative,
The institute of Medical Science, The
University of Tokyo

特任准教授 中江進

Associate Prof. Susumu Nakae

千葉大学大学院医学研究院

Department of Molecular Genetics,
Graduate School of Medicine, Chiba
University

大阪大学生物工学国際交流センター

講師

廣瀬

晃一

助教

大橋

貴生

佐藤

浩昭

Lecturer

Koichi Hirose

International Center for Biotechnology

Assistant Prof. Takao Ohashi（独）産業技術総合研究所

主任研究員

The National Institute of Advanced
Development of identification and classification on fungi based on mass spectrometry of ribosomal
Industrial Science and Technology
proteinSeniorResearcher

Hiroaki Sato16୺せ◊✲ᶵჾ࣭タഛ࡟ࡘ࠸࡚
Research Equipment and Facilitiesᮏࢭࣥࢱ࣮࡛ࡣࠊ௨ୗࡢࡼ࠺࡞◊✲ᶵჾࡸタഛࡀ฼⏝ྍ⬟࡛ࡍࠋࡇࢀࡽࡣࠊඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬࡢ◊✲ㄢ㢟ࡔࡅ࡛࡞ࡃࠊᵝࠎ࡞◊✲άື࡟౑⏝ࡋ࡚࠸ࡓࡔࡃࡇ࡜ࡀ࡛ࡁࡲࡍࠋࡑࢀࡒࢀࡢᶵჾ࠾ࡼࡧタഛࡢᢸᙜᩍဨࢆグ㍕ࡋ࡚࠶ࡾࡲࡍࡢ࡛ࠊ࠾ၥ࠸ྜࢃࡏࡢ࠺࠼ࡈ฼⏝ࡃࡔࡉ࠸ࠋMMRC provides the following research equipment and facilities for domestic and foreign researchers.
Please contact the relevant faculty members to use our research equipment.
Ӑ㟁ヰ (TEL)㸸043-222-7171 (௦⾲ : Key number)ӑ

୺せ◊✲ᶵჾ (Research Equipment)(1) ḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ (Next Generation Sequencer) (ᯇ⃝ ෆ⥺ 5916)
ձ

MiSeq (Illumina)ղ

GS Junior 454 (Roche)(2) ࢔ࢥ࣮ࢫࢸ࢕ࢵࢡࢯࣝࣅࣛ࢖ࢨ࣮ (M&S Instruments, Covaris㸸ᯇ⃝ ෆ⥺ 5916)(3) DNA ᩿∦໬⿦⨨ ࣁ࢖ࢻࣟࢩ࢙࢔ (Asahi Life Science, DIGILAB㸸ᯇ⃝ ෆ⥺ 5916)(4) 㑇ఏᏊࢹ࣮ࢱゎᯒࢩࢫࢸ࣒ (Genetic analyzer) (▮ཱྀ ෆ⥺ 5918)
ձ

ABI Prism 3130 Genetic analyzer 673-A

ղ

ABI Prism 3130N

MiSeq(5) 㢧ᚤ㙾 (Microscope)ձ

㏱㐣㟁Ꮚ㢧ᚤ㙾 (JEOL, JEM-1400㸸ᒣཱྀ ෆ⥺ 5928)

ղ㉮ᰝ㟁Ꮚ㢧ᚤ㙾 (HITACHI, S-3400N㸸▮ཱྀ ෆ⥺ 5918)

ճⴠᑕ⺯ගᚤศᖸ΅㢧ᚤ㙾 (Nikon, Y-FL㸸⏣୰ ෆ⥺ 5916)

մඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾 (Zeiss, LSM 5 EXCITER㸸኱ᴋ ෆ⥺ 5941)

յ࣮࢜ࣝ࢖ࣥ࣡ࣥ⺯ග㢧ᚤ㙾⿦⨨ (KEYENCE, BZ-9000㸸ᑿ㔝ᮏ ෆ⥺ 5919)

ն㢧ᚤ⺯ගᐃ㔞

շࣂ࢖࢜ࢭࣝࢺ࣮ࣞࢧ࣮ (Hidan, BioCell-Tracer㸸⏣ཱྀ ෆ⥺ 5914)

ග⿦⨨ (OLYMPUS, LUZEX IID㸸኱ᴋ ෆ⥺ 5941)

GS Junior(6) ᛴ㏿෾⤖⿦⨨ (GmbH, EMCPC-M㸸ᒣཱྀ ෆ⥺ 5928)(7) ࢘ࣝࢺ࣑ࣛࢡࣟࢺ࣮࣒ (Leica, Ultracut S㸸ᒣཱྀ ෆ⥺ 5928)(8) ࢧ࢖ࢺ࣓࣮ࢱ࣮ (Cytometer)ձ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥࢧ࢖ࢺ࣓࣮ࢱ࣮ (OLYMPUS, LSC-101㸸኱ᴋ ෆ⥺ 5941)

ղࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮ (On-chip, FISHMAN-R㸸⏣୰ ෆ⥺ 5916)(9) ศගගᗘィཬࡧ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮ (Spectrophotometer & Image Analyzer)17ձ⣸እྍどศගගᗘィ (Shimazu UV-2500PC㸸኱Ⲩ⏣ ෆ⥺ 5916)

ղ㉥እศගගᗘィ (Jasco FT/IR-420㸸኱Ⲩ⏣ ෆ⥺ 5916)

ճ⺯ගศගගᗘィ (PerkinElmer, PL-50B㸸㙑⏣ ෆ⥺ 5913)

մ⏕≀Ⓨග࣭໬ᏛⓎග࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜࢲ࣮ (Perceptive Biosystems 400㸸㙑⏣ ෆ⥺ 5913)

յ࢖࣓࣮ࢪࣥࢢ࢔ࢼࣛ࢖ࢨ࣮ (Amersham, Typhoon 8610㸸኱ᴋ ෆ⥺ 5941)

ն࣑ࣝࣀ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮ (Fujifilm, LAS-1000UVmini㸸ΎỈ ෆ⥺ 5941)

շࣇࣝ࢜ࣟ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮ (Fujifilm, FLA-7000㸸⏣୰ ෆ⥺ 5916)㏱㐣㟁Ꮚ㢧ᚤ㙾

(10) ㉁㔞ศᯒ⿦⨨ (Mass Spectrometry)ձ

LC-MS/MS (ABI, API QstarPulsar㸸ΎỈ ෆ⥺ 5941)

ղ

GC/MS (Hewlett-Packard, HP6890㸸ᶓᒣ ෆ⥺ 5917)(11) 㐲ᚰᶵ (Centrifuge)ձከᶵ⬟ᚤ㔞㧗㏿㐲ᚰᶵ (Beckman, Allegra X-12㸸ᯇ⃝ ෆ⥺ 5916)

ղ༟ୖ㉸㐲ᚰᶵ (Beckman, OptimaTLX㸸኱ᴋ ෆ⥺ 5941)(12) ᾮయࢩࣥࢳ࣮ࣞࢩࣙࣥ࢝࢘ࣥࢱ࣮ (Aloka, LSC-5100㸸⏣୰ ෆ⥺ 5916)(13) 㑇ఏᏊᑟධ⿦⨨ (Bio-Rad, PDS-1000/He㸸ΎỈ ෆ⥺ 5941)(14) ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼ࣮ (GENOMIC SOLUTIONS, GeneTAC UCII㸸ΎỈ ෆ⥺ 5941)(15) PCRձࣜ࢔ࣝࢱ࢖࣒ PCR (ABI, PRISM 7000㸸኱Ⲩ⏣ ෆ⥺ 5916)

ղࣜ࢔ࣝࢱ࢖࣒ PCR (ABI, PRISM 7300㸸኱Ⲩ⏣ ෆ⥺ 5916)

ճࢧ࣮࣐ࣝࢧ࢖ࢡ࣮ࣛ (Takara, MPTF-3100㸸㙑⏣ ෆ⥺ 5913)

GC/MS(16) ࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝ (YASUI KIKAI, MU601U(S)㸸኱ᴋ ෆ⥺ 5941)(17) ࢥࣟࢽ࣮ࣆࢵ࣮࢝ (Microtec, Pick-in Master PM-2 multi㸸▱ⰼ ෆ⥺ 5932)(18) ኱ᆺࣉࣜࣥࢱ࣮ (EPSON PX-H9000㸸㙑⏣ ෆ⥺ 5913)(19) ᐇ㦂ື≀⏝ X ⥺ CT ⿦⨨ (Hitachi-Aloka Medical, Latheta LCT200㸸ᮧ㛗 ෆ⥺ 5912)

୺せ◊✲タഛ (Research Facilities)ᐇ㦂ື≀⏝ X ⥺ CT ⿦⨨(1) ኱つᶍ PC ࢡࣛࢫࢱࢩࢫࢸ࣒ (Large scale PC Cluster System)(2) SPF ື≀ឤᰁᐇ㦂ᐊ (SPF laboratory animal facility for experimental infections)(ᖹᡂ 26 ᖺᗘ᫓᏶ᡂணᐃ)(3) BSL3 ᑐᛂᐇ㦂ᐊ (BSL3-compliant laboratory)(4) ࣛࢪ࢜࢔࢖ࢯࢺ࣮ࣉ (RI) ◊✲᪋タ (Radioisotope Research Facility)

PC ࢡࣛࢫࢱࢩࢫࢸ࣒SPF ື≀ឤᰁᐇ㦂ᐊ 3D タィᅗ ཬࡧື≀㣫⫱ᐊண᝿ᅗ
18኱Ꮫ㝔࡟࠾ࡅࡿ◊✲ᣦᑟཬࡧⱝᡭ◊✲⪅ࡢ⫱ᡂPromotion of the Young Investigators
本センターは、我が国で唯一、次世代の真菌医学研究者を育成する重要な使命を担っており、学内および学外から多くの大学院生や研究生を受け入れ、教員が研究の現場で研究指導を直接行っています。学内では、平成 24
年度（2012 年）に採択された文部科学省博士課程教育リーディングプログラム「免疫システム調節治療学推進
リーダー養成プログラム」へ参画し、国際的なリーダーの育成事業に貢献しています。また外部から研究者を招き、セミナーやシンポジウムを積極的に開催しています。さらに、千葉大学で平成 20 年度より導入されたテニュアトラック制度を活用して、若手研究者の自立支援に積極的に取り組んでいます。国内外からの若手研究者を受け入れ、研究の国際交流を促進するとともに、帰国後も研究指導を継続し、共同研究成果を論文として発表してきました。センターでは、教職員が一丸となって若手研究者・大学院生の研究・教育に努力しています。
MMRC is only research institution in Japan where comprehensive studies on fungal infection andpathogenic fungi are conducted. We offer a stimulating environment for students and young scientists togain systematic experience. Both Japanese and international students with broad range of knowledge areable to study in MMRC and establish a broad foundation of knowledge by outstanding faculty members.
Moreover, we strongly support young scientists to succeed as highly talented researchers.

Ꮫ⏕᥍ᐊ

19

ᾏእ࠿ࡽࡢ␃Ꮫ⏕ᐇ㦂㢼ᬒ◊✲ᣦᑟ㢼ᬒ

ࣛ࣎ࢭ࣑ࢼ࣮

༤ኈᚋᮇㄢ⛬ 2 ᖺ ㉥ᫍ ဴᖹ

኱Ꮫ 4 ᖺ⏕ ᪩ᕝ ┿⌮Ꮚ┿⳦ࢭࣥࢱ࣮ࡢ࿘ࡾ࡟ࡣࠊ㇏࠿࡟ⲡᮌࡀ⏕࠸ⱱࡗ࡚ࢤࣀ࣒ᐇ㦂ࢹ࣮ࢱࡢ㔞ࡀ⭾኱࡜࡞ࡾࡘࡘ࠶ࡿ㏆ᖺ࡟࠾ࡾᏘ⠇ࡢ⛣ࢁ࠸ࢆ㌟㏆࡟ឤࡌࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋᚲせ࡜ࡉࢀࡿ▱㆑࡛࠶ࡿ⏕≀࡜᝟ሗࡢ⼥ྜᏛၥࠊࣂ

◊✲ᐊࡢ❆࠿ࡽእࢆなࡃ࡜ࠊ᫓࡟ࡣᱜࡀ⥡㯇࡟ဏࡁ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫࢆᏛࢇ࡛࠸ࡲࡍࠋ᪥ᮏ࡛ࡣ

㄂ࡗ࡚࠸࡚ࠊᐇ㦂࡟ኻᩋࡋ࡚ᡴࡕࡦࡋࡀࢀࡓᚰࢆඃ

ࡲࡔ࣓ࢪ࣮ࣕ࡜࠸࠸㞴࠸ศ㔝࡛኱ኚ࡞ࡇ࡜ࡶከ࠸࡛

ࡋࡃ⒵ࡋ࡚ࡃࢀࡲࡍࠋ෤ࡣᐢࡋࡃ

ࡍࡀࠊࡇࡢ◊✲࠿ࡽ⏕≀ࡢ᪂ࡓ࡞࡞ࡗࡓᮌࠎ࠿ࡽ࢝ࢱࣝࢩࢫࢆᚓࡿ᪉ྥᛶࢆぢࡘࡅࠊ⏕≀ᏛࡢⓎᒎ࡟ࡇ࡜ࡀ࡛ࡁࠊࡇࡢ⎔ቃࢆ࡜࡚ࡶ

㈉⊩ࡋࡓ࠸࡜ᛮ࠸᪥ࠎ◊✲ࢆẼ࡟ධࡗ࡚࠸ࡲࡍࠋ

⾜ࡗ࡚࠸ࡲࡍࠋ

真菌医学研究センター病原真菌講習会
The Training Course of Pathogenic Fungi
病原真菌講習会は、病原真菌・放線菌の基本的取り扱いの知識と技術を習得するために、本センターが実習を中心にして実施している講習会で、年 1 回定員 12 名で開催している。2013 年度は第 27 回目に当たり、累積
受講生は 320 名余になる。例年、定員大きく超える応募があり、大変好評を得ている。
We annually hold the training course of pathogenic fungi to learn knowledge and technique in order totreat pathogenic fungi and actinomycetes and the number of participants is 12. This year, this course has
been held 27 times and total number of participants is over 320. Every year, a number of application,is overthe participant and the course has been in a great demand.
期日: 例年 7 月に 4 日間
会場: 千葉大学真菌医学研究センター講習会室、講堂
内容（実習・講義）: 病原性酵母、病原性アスペルギルス、皮膚科領域真菌症原因菌、輸入および新興
病原真菌、病原性接合菌、病原性放線菌、薬剤感受性試験法、菌株保存法、感染症法、ウイルス概論など
講習生内訳
2008 年2009 年

2010 年

2011 年

2012 年2013 年

臨床検査関係（病院、企業）

6

9

5

8

7

5

医師・歯科医師・薬剤師

0

0

5

2

3

4

大学、公的研究機関

3

1

1

1

1

1

行政関係（保健所など）

1

1

0

0

0

0

バイオ関連企業

2

1

1

1

1

2

関東

8

3

8

6

7

8

東北・北海道

0

1

0

1

0

1

中部

1

1

2

0

1

1

近畿

1

3

0

1

0

2

中四国

1

2

0

3

0

0

九州・沖縄

1

2

1

1

4

0

(職種)

(地域)

(海外)

(1)

20






ᅜ㝿஺ὶ༠ᐃ㸦኱Ꮫ㛫஺ὶ༠ᐃ࣭㒊ᒁ㛫஺ὶ༠ᐃ࡞࡝㸧
Inter-University and Faculty-level Exchange Agreements

 真菌医学研究センターでは積極的に海外の大学との大学間交流協定や部局間交流協定を締結し､国際交流､国際共同研究を活発に推進している。大学間の交流協定としては1996年のハンガリー共和国デブレツェン大学との締結に続き、2001年にブラジル連邦共和国サンパウロ州立カンピーナス大学との間に協定を締結した。これらは大学間の協定ではあるが、いずれにおいても協定締結を始めとして､その後の交流活動においても真菌医学研究センターが中心的な役割を果たしている。また、本センターと海外の学部・部局との協定（部局間交流協定）としてはタイ国保健省医科学局国立衛生研究所 (2002年)、チェコ共和国パラツキー大学医学歯学部 (2007年)、中国吉林大学白求恩医学院 (2008年)、中国新疆医科大学附属第一病院 (2010年)、ブラジル連邦共和国パラナ州立
ロンドリーナ大学生物学研究所 (2011年) と協定を締結して交流を進め､ 更に2012年にはブラジル連邦共和国
サンパウロ州立サンパウロ大学医学部と協定を結んだ。同校からはこれまでも研究者を受け入れるなどして共同研究を進めてきたが､この締結により今後、真菌感染症の臨床及び臨床微生物学的分野における共同研究のいっそうの推進が期待される。尚、これらの協定締結先とはいずれも活発な共同研究を継続している。
これらの協定外の交流としては、日本学術振興会・平成20年度外国人特別研究員事業で中国、ブラジル、インドネシア、チェコから日本学術振興会・平成22年度外国人特別研究員事業ではニュージーランド等から研究者を受け入れ、さらに平成24年度にもバングラデシュから研究者を受入れ､国際共同研究を積極的に推進している。
We have performed collaborative research with a number of universities and faculties around the world;
these include the National Institute for Health (Thailand), Palacky University (Czech), Xinjiang Medical
University (China), Jilin University (China), and the State University of Londrina (Brazil). These efforts
are based on inter-university and inter-faculty-level exchange contracts. In 2012, we established a newinternational exchange agreement with the Faculty of Medicine, State University of Sao Paulo (Brazil),which allows us to accept researchers for the study on fungal infections to encourage and further promotecollaboration in science between the two academic units.

Number of International Joint Researchers and Students‫ڦ‬ᅜ㝿ⓗ࡞ඹྠ◊✲ဨ➼ࡢཷධ≧ἣ(Number of International Joint Researchers)
 ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ༊  ศ
እᅜே◊✲ဨ(International Research Scientist)





እᅜே◊✲⪅(International Researcher)





ᅜ㝿༠ຊᶵᵓ࡟ࡼࡿཷධ(Joint Researcher from JICA)





ࡑࡢ௚(Other)






ᅜ㝿ⓗ࡞ඹྠ◊✲ဨ➼ཬࡧᏛ⏕ࡢཷධ≧ἣ‫ڦ‬Ꮫ⏕ࡢཷධ≧ἣ(Number of Students)

༊  ศ
 ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ◊ ✲ ⏕(Research Student)





◊✲␃Ꮫ⏕(International Research Student)





་Ꮫ⸆Ꮫᗓ





(Medical and Pharmaceutical Sciences)
኱Ꮫ㝔⏕(Graduate Student)⼥ྜ⛉Ꮫ◊✲⛉





(Advanced Integration Science)
Ꮫ 㒊 ⏕(Undergraduate Student)







21





㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᣐⅬ≉ᐃ㡿ᇦඹྠ◊✲
Cooperative Research of Priority Areas with NEKKEN, Nagasaki Universityࠕ⇕ᖏᆅᇦࠊ≉࡟࢔ࣇࣜ࢝࠾ࡼࡧ࣋ࢺࢼ࣒࡛Ⓨ⏕ࡋ࡚࠸ࡿ┿⳦⑕࣭ᨺ線⳦⑕ࡢཎᅉ⳦ࡢ཰㞟࡜ᙧែᏛⓗࠊ⏕⌮ᏛⓗࠊศᏊ⏕≀Ꮫⓗゎᯒࠖࣉࣟࢪ࢙ࢡࢺ
㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤࢣࢽ࢔ᣐⅬࢆ୰ᚰ࡟ࠊୖグࣉࣟࢪ࢙ࢡࢺࢆᒎ㛤ࡋ࡚࠸ࡲࡍࠋ⌧ᅾࡲ࡛࡟ࢣࢽ࢔඲ᅵࡢ୺せ✐≀ (ࢺ࢘ࣔࣟࢥࢩࠊᑠ㯏) ࡸ࣑ࣝࢡ࡞࡝ࢆởᰁࡍࡿ࢝ࣅẘ(Ⓨࡀࢇᛶ࢔ࣇࣛࢺ࢟ࢩࣥ௚)࡜ࡑࡢ⏕⏘⳦ࡢゎᯒࢆ㐍ࡵࠊ⌧ᆅ㣗≀ࡢከࡃࡀࠊୡ⏺ࡢᏳ඲ᇶ‽್ࢆ኱ࡁࡃୖᅇࡿ࢝ࣅẘ࡛ởᰁࡉࢀ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ
⤖ᯝࡣ᫖ᖺᗘࠊ⌧ᆅࡢ࣐ࢫࢥ࣑࡟ࡶྲྀࡾୖࡆࡽࢀࠊ኱ࡁ࡞཯㡪ࢆ࿧ࡧ㉳ࡇࡋࡲࡋࡓࠋࡲࡓ᪂ࡓ࡟⌧ᆅ࡛ࠊ࢚࢖ࢬ
ᝈ⪅ࡢ࿨ࢆዣ࠺୺࡞ཎᅉ࡛࠶ࡿ┿⳦ឤᰁ⑕ࠊ≉࡟ࢡࣜࣉࢺࢥࢵ࢝ࢫᒓ⳦࡟ࡼࡿឤᰁࢆ୰ᚰ࡟␿Ꮫⓗㄪᰝࢆィ⏬ࡋ࡚࠸ࡲࡍࠋ ᾏእ࡛ࡢ◊✲ࡣࠊ⌧ᆅࡢ◊✲⪅ࡸ┘╩ᐁᗇ࡜ಙ㢗㛵ಀࢆ⠏ࡁࠊチྍࢆᚓࡿ࡞࡝ከࡃࡢၥ㢟ࢆゎỴࡋ࡞ࡅࢀࡤ๓㐍࡛ࡁࡲࡏࢇࠋࡋ࠿ࡋࠊ⌧ᆅࡢ་⒪࡟㈉⊩ࡋࠊேࠎࡢ⏕άࡢ㉁ (QOL) ࡢྥୖࢆᅗࡾࠊࡉࡽ࡟᪥ᮏ࡜ࡢ཭ዲࢆ῝ࡵࡿࡓࡵ࡟ດຊࢆ㔜ࡡ࡚࠸ࡲࡍࠋ୍᪉ࡇࢀࡽࡢ◊✲ࡣᆅ⌫ࡢࢢ࣮ࣟࣂࣝ໬ࠊ ᬮ໬ࠊ⎔ቃ࣭㣗⣊஦᝟ࡢᝏ໬ࡀ㐍ࡴ୰࡛ࠊ᪥ᮏࡢேࠎࡢ་⒪ࡸ QOL ࡢ⥔ᣢ࡟ࡶࠊᑗ᮶኱ࡁࡃ㈉⊩ࡍࡿࡣࡎ࡛ࡍࠋ
Project for Morphological, Physiological and Molecular Biological Analysis
of Pathogenic Fungi and Actinomycetes Collected in Africa and Vietnam
Under assistance of Kenya Research Station, Inst. NEKKEN, Nagasaki
univ., we are analyzing toxins contaminating major local grains (maze,
wheat) and milks, and also producer fungi. We found the local foods arecontaminated by the toxins at concentrations far above the international
standards. The result has been announced in newspapers, and received
large attention. A new project for epidemiological study of Cryptococcal
fungi in HIV-infected patients is launched in collaboration with Kenya
Medical Res. Insti. (KEMRI) and doctors from UCSF, USA.

2012 ᖺ 2 ᭶ ࢣࢽ࢔ᅜ࢟ࢫ࣒ᕷ
ࡢ⑓㝔࣭◊✲᪋タၥᆅ⌫つᶍㄢ㢟ᑐᛂᅜ㝿⛉Ꮫᢏ⾡༠ຊ஦ᴗ(JST&JICA)
SATREPS project (Science and Technology Research Partnership for Sustainable Development)
㺀AIDSᝈ⪅ཬࡧࡑࡢ௚ࡢච␿୙඲ᝈ⪅࡟࠾ࡅࡿ᪂つデ᩿ἲ࡟ࡼࡿ┿⳦⑕ᑐ⟇㺁ࣉࣟࢪ࢙ࢡࢺ
独立行政法人 国際協力機構（JICA）および独立行政法人 科学技術振興機構（JST）の地球規模課題対応国際
科学技術協力事業（SATREPS）により、平成22年度よりブラジル連邦共和国サンパウロ州立カンピーナス大学
医学部感染症科との間で協力事業を実施した。目的はAIDSを始めとした免疫不全患者における真菌症の診断法・治療法の研究を推進・実用化し、その成果をブラジルに提供して両国の医療の向上に役立てることにある。
主なテーマは本センターで開発したDNAチップによる病原真菌の同定及び真菌症の診断、β-グルカンによる真菌症の診断、リアルタイム PCR 及び LAMP 法による真菌症の診断・原因菌の同定、薬剤最適投与法の検討等である。3年間の実施期間を完了し平成24年度に終了したが、本プロジェクトの研究成果はブラジルを始めとして周辺中南米諸国およびブラジルの影響下にあるポルトガル語圏アフリカ諸国の医療レベルにも影響を与える大規模なものであり、本プロジェクトは終了時評価で「A+」の高評価を得た。なおこの終了時評価については、
http://www.jst.go.jp/global/hyouka/index.htmlにて閲覧可能である。
Diagnostic Approaches in the Management of Fungal Infections in AIDS and Other Immunocompromised Patients

Increasing numbers of fungal infections caused by yeasts and moulds are a serious threat not only to the Japanesesociety, but also to many other countries, including Brazil. These infections hamper the patients' quality of life andsometimes claims their lives. In this SATREPS project, sponsored by JST and JICA, we worked together with theDivision of Infectious Diseases, University Hospital of UNICAMP (State University of Campinas, Brazil) to develop
accurate, rapid, and sensitive diagnostic methods for fungal infections, such as
DNA chips for the infection, and applied these methods to clinical cases in Brazil.
The project was performed during FY2010 to FY2012, and the results were very
promising. Our project was highly rated by the evaluation committee with thescore of A+ on completion of the project term. Since these new technologies can beapplied to diagnosis of patients in other countries, particularly in South America
and Portuguese-spoken African countries, the fruit of our study is expected to give
substantial beneficial ripple effects to these societies.

2012 ᖺ 11 ᭶⤊஢᫬ホ౯఍࡟࡚22

予算状況
予算状況
Budget■運営費
Management Expenses Grants■運営費Management Expenses Grants
区 区分 分
研究関連経費研究関連経費
平成16年度(2004)
平成16年度(2004)
平成17年度(2005)

平成17年度(2005)

平成18年度(2006)

平成18年度(2006)

平成19年度(2007)
平成19年度(2007)
平成20年度(2008)
平成20年度(2008)
平成21年度(2009)
平成21年度(2009)
平成22年度(2010)
平成22年度(2010)
平成23年度(2011)
平成23年度(2011)
平成24年度(2012)
平成24年度(2012)

Budget

特
別経
経費
費
特 別


















管管
理理
経経
費 費




















■ナショナルバイオリソースプロジェクトNational BioResource Project■ナショナルバイオリソースプロジェクト
再委託金額National BioResource
Project
区分
委託金額
委託金額合計

委託金額 
再委託金額
委託金額合計




代表機関分
分担機関分
プロジェクト総額

平成18年度(2006)

代表機関分 
分担機関分
プロジェクト総額
平成19年度(2007)


平成18年度(2006)

平成20年度(2008)

平成19年度(2007)


平成21年度(2009)

平成20年度(2008)

平成22年度(2010)

平成21年度(2009)

平成23年度(2011)


平成22年度(2010)

平成24年度(2012)

平成23年度(2011)


■科学研究費補助金Grants-in-Aid
for Scientific Research
平成24年度(2012)


平成22年度(2010)■奨学寄附金 Donation
平成23年度(2011)
区分
平成24年度(2012)

平成16年度(2004)
平成17年度(2005)■奨学寄附金Donation
平成18年度(2006)平成19年度(2007)
区分
平成20年度(2008)
平成16年度(2004)
平成21年度(2009)平成17年度(2005)
平成22年度(2010)平成18年度(2006)平成23年度(2011)平成19年度(2007)平成24年度(2012)

23

１０件
１０件
件数１３件

６件
１７件
２８件
件数 ２２件
１４件
６件
１６件
１７件
２２件
２８件
２４件
２２件
１６件



受入金額




受入金額









平成20年度(2008)
１４件
平成21年度(2009)
１６件 Research■民間等との共同研究等 Collaborative
平成22年度(2010)
２２件
民間等との共同研究
区分
平成23年度(2011)
２４件
平成16年度(2004)
４件
平成24年度(2012)
１６件
平成17年度(2005)
５件







平成18年度(2006)
３件
平成19年度(2007)
５件 Research■民間等との共同研究等 Collaborative
平成20年度(2008)
２件
民間等との共同研究
区分
平成21年度(2009)
３件
平成16年度(2004)
４件
平成22年度(2010)
４件
平成17年度(2005)
５件
平成23年度(2011)
４件
平成18年度(2006)
３件
平成24年度(2012)
２件











平成19年度(2007)
平成20年度(2008)
平成21年度(2009)平成22年度(2010)平成23年度(2011)平成24年度(2012)

５件
２件
３件
４件
４件
２件








計
















備

平成16年度(2004)
区分
平成17年度(2005)
平成16年度(2004)
平成17年度(2005)

件数（文部科学省）
区
分
採択金額
平成16年度(2004)
６件

■科学研究費補助金Grants-in-Aid for Scientific Research
平成17年度(2005)
７件
件数（文部科学省）
区
分
採択金額
平成18年度(2006)
８件

平成16年度(2004)
６件

平成19年度(2007)
８件

平成17年度(2005)
７件
平成20年度(2008)
８件

平成18年度(2006)
８件

平成21年度(2009)１０件

平成22年度(2010)
１０件
平成19年度(2007)
８件

平成23年度(2011)
１０件
平成20年度(2008)
８件

平成24年度(2012)
１３件

平成21年度(2009)１０件


計

考

備

考

４件
３件
件数（他省庁）
４件
２件４件
３件３件
３件４件
３件２件
１件３件
１件３件

採択金額


採択金額

  
 
  

３件
１件
１件





件数（他省庁）

受託研究・受託事業
１件

１件

４件

８件

受託研究・受託事業
６件
８件

５件１件
 
１件
４件
 
４件
単位：千円 Unit:thousand yen 

８件

６件

８件

５件

４件

単位：千円 Unit:thousand yen㐠ႠAdministration ᙜࢭࣥࢱ࣮ࡢ㐠Ⴀࡣࠊᩍᤵ఍࡟┦ᙜࡍࡿ㺀ᩍဨ఍㆟㺁࡜ࠊᮏᏛࡢᩍᤵཬࡧᏛእࡢᏛ㆑⤒㦂⪅ࢆྵࡵࡓ㺀㐠Ⴀ༠㆟఍㺁࡟ࡼࡗ࡚⾜ࢃࢀࡿࠋMMRC management and decision are made by Faculty Meeting and Scientific Council, composed of the internal
professors and external experts.

教員会議構成員
Member of FacultyCommittee㐠Ⴀ༠㆟఍ጤဨ
Member of ScientificCouncil➲ᕝࠉ༓ᑜࠉ
≉௵ᩍᤵ
Professor
Chihiro Sasakawa
ᩍࠉᤵ㸲ྡProfessor෸ᩍᤵ㸳ྡAssociate Prof.
㔝ᮧࠉᩥኵ
ᩍࠉᤵ
Fumio Nomura
ProfessorᯇỤࠉᘯஅᩍࠉᤵᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔
Hiroyuki Matsue
Graduate School of Medicine, Chiba University
Professorㄢࠉ㛗஻㰯ᆅ༊஦ົ㒊⟶⌮ㄢ㸯ྡ
Inohana Area Administrative Office
Head
ᆤ஭ࠉⰋ἞
ᮾி་⛉኱Ꮫ
ᩍࠉᤵ
Ryoji Tsuboi
Tokyo Medical University
Professor➲ᕝࠉ༓ᑜ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗≉௵ᩍᤵChihiro Sasakawa
MMRC, Director
Professor┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
ᩍࠉᤵ
㸲ྡ
MMRC
Professor㔝ᮧࠉᩥኵᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔ᩍࠉᤵFumio Nomura
Graduate School of Medicine, Chiba University
ProfessorᯇỤࠉᘯஅᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔ᩍࠉᤵ
Hiroyuki Matsue
Graduate School of Medicine, Chiba University
Professor஬࿡ࠉ຾ஓᩍࠉᤵᮾ໭኱Ꮫ኱Ꮫ㝔㎰Ꮫ◊✲⛉
Graduate School of Agricultural Science, Tohoku University
Katsuya
Gomi
Professor⯓⏣ࠉ୍༤ᩍࠉᤵᮾ㑥኱Ꮫ་Ꮫ㒊
Kazuhiro Tateda
Faculty of Medicine, Toho University
Professorඵᮌ⃝ࠉᏲṇ
៞᠕⩏ሿ኱Ꮫ⸆Ꮫ㒊ඹྠ◊✲ဨFaculty of Pharmacy, Keio University
Senior Researcher Morimasa Yagisawa┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗
MMRC, Director┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
MMRC┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
MMRC
ᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔Graduate School of Medicine, Chiba Universityᕝᓮᕷ೺ᗣᏳ඲◊✲ᡤ
Kawasaki City, Institute for Public Healthᡤࠉ㛗
Directorᒸ㒊ࠉಙᙪ
Nobuhiko Okabeᅜ❧ឤᰁ⑕◊✲ᡤ
National Institute of Infectious Diseases㒊ࠉ㛗
Director࢟ࢵࢥ࣮࣐ࣥओᛂ⏝◊✲㛤Ⓨ㒊㒊ࠉ㛗
Directorᐑ㷂ࠉ⩏⥅
Yoshitsugu MiyazakiᲚᒣࠉ┤ᶞNaoki Kajiyama

Research and Development Division, Kikkoman Corporation⫋ဨᩘ (ᖖ໅⫋ဨ) Number of Staff Members
༊ศ
ᩍᤵ
෸ᩍᤵ

ᖹᡂ 25 ᖺ 4 ᭶⌧ᅾ
୍⯡⫋ဨ➼
ィ

ㅮᖌ

ຓᩍ

Iteam

Professors

Associate Profs.

Lecturers

Assistant Profs.

Researchers & staffs

Total⌧ဨ Present Number

4

5

0

5

6

20

஻㰯ᆅ༊஦ົ㒊⟶⌮ㄢ
Inohana Area Administrative Office Financial Planning Division஦ົ㒊㛗(ව ⟶⌮ㄢ㛗) 㟷ᮌ ⁠Director
Shigeru Aoki๪⟶⌮ㄢ㛗      ᑠᕝ ௦ᯞ⏕ Deputy Head
Yoshio Ogawa⟶⌮࣭◊✲ᨭ᥼ಀ㛗  ᒸ⏣ ಇⱥ
ChiefToshihide Okada┿⳦ࢭࣥࢱ࣮ᨭ᥼ಀMMRC Supportಀ㛗Ώ㑓 ᬛᏊ
Chief    Tomoko Watanabe୺௵㧗᲍ ṇ⏨
Unit Chief
Masao Takanashi㠀ᖖ໅⫋ဨΏ㑓 ࿴Ꮚ
Part-time Staff Kazuko Watanabe24࢔ࢡࢭࢫ࣐ࢵࣉ
Location and Access Map

Location of
Chiba University Campus

After arriving at JR Chiba Station or Keisei Chiba Station, take buses bound for "Chiba University
Hospital" or "Minami-Yahagi" at bus station in east front exit 7 of JR Chiba Station, and get off at"Faculty of Pharmaceutical Sciences" or “Chuo-Hakubutsukan” bus stop. Approximately 15–30
minutes for both.
25

㻌
㻌
㻞㻡

MMRC atInohanan

Map of MMRC in Inohana Campus

Chuo-Hakubutsukan
Bus Stop

㻌
㻌
㻞㻢

26

& MMRCJR ༓ⴥ㥐ࠊிᡂ༓ⴥ㥐฿╔ᚋࠊJR ༓ⴥ㥐ᮾཱྀṇ㠃 7 ␒ࡢࣂࢫ஌ࡾሙ࠿ࡽࠕ༓ⴥ኱Ꮫ⑓㝔ࠖ⾜ࡁࡲࡓࡣࠕ༡▮సࠖ⾜ࡁࣂࢫ࡟஌㌴ࠊࠕ୰ኸ༤≀㤋࡛ࠖୗ㌴ࠊᚐṌ 1 ศࠋඹ࡟⣙ 15 ศࠋ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
ࠛ260-8673 ༓ⴥ┴༓ⴥᕷ୰ኸ༊஻㰯 1 ୎┠ 8 ␒ 1 ྕ
TEL 043 (222) 7171 (௦⾲) FAX 043 (226) 2486
(࣮࣒࣮࣍࣌ࢪ: http://www.pf.chiba-u.ac.jp/ )