MMRC
Medical Mycology Research Center, Chiba University༓ⴥ኱Ꮫ ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮

ᴫせ

2017

-Leading the medical mycology research-ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ ┿⳦ឤᰁ⑕◊✲ᣐⅬඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ ⑓ཎ┿᰾ᚤ⏕≀┠ḟ (Contents)ࡣࡌࡵ࡟ (Preface) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy2ἢ㠉 (Historical Chart) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy3Ṕ௦ᡤ㛗࣭ࢭࣥࢱ࣮㛗 (Successive Directors) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy3ᶵᵓᅗ (Organization) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy4┿⳦⑕◊✲㒊㛛 (Department of Mycosis Research) ឤᰁච␿ศ㔝 (Division of Molecular Immunology) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy5ឤᰁᛂ⟅ࣉࣟࢪ࢙ࢡࢺ (Project for Immune Response in Infectious Diseases)ࢧ࢖ࢺ࢝࢖ࣥࣉࣟࢪ࢙ࢡࢺ (Project for Cytokine Research)ᚤ⏕≀࣭ච␿ไᚚࣉࣟࢪ࢙ࢡࢺ (Project for Host-Microbial Interactions in Symbiosis and Pathogenesis)⑓ཎᶵ⬟ศ㔝 (Division of Molecular Biology) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy8࢝ࣥࢪࢲࣇ࢙ࣀ࣮࣒ࣉࣟࢪ࢙ࢡࢺ (Candida Phenome Project)⮫ᗋឤᰁ⑕ศ㔝 (Division of Clinical Research) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy9⮫ᗋឤᰁ⑕ࣉࣟࢪ࢙ࢡࢺ (Project to Link Basic Sciences and Clinical Researches)ឤᰁᐟ୺ᛂ⟅ࢿࢵࢺ࣮࣡ࢡࣉࣟࢪ࢙ࢡࢺ (Project for Host Response Network of Bacterial Infection)ศᏊ⣽⬊ࢩࢢࢼࣜࣥࢢゎᯒࣉࣟࢪ࢙ࢡࢺ (Project for Molecular Signaling Analysis) ឤᰁ⑕ไᚚศ㔝 (Division of Infection Control and Prevention) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy11ឤᰁ⑕ไᚚࣉࣟࢪ࢙ࢡࢺ (Project for Infection Control and Prevention)

RNA ឤᰁ἞⒪Ꮫศ㔝 (Division of RNA Therapy) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy 12
 RNA ไᚚࣉࣟࢪ࢙ࢡࢺ (Project for RNA Regulation)
ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy 13ᚤ⏕≀๰⏕ࣉࣟࢪ࢙ࢡࢺ (Project for Systems Biology of Microorganisms)ࣂ࢖࢜ࣜࢯ࣮ࢫ⟶⌮ᐊ (Management Unit of Microbiological Resources)┿⳦⑕ᑓ㛛እ᮶ (Specialty Clinic for Invasive Fungal Diseases) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy15ࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ (National BioResource Project) yyyyyyyyyyyyyyyyyyyyyyyyyyy16ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ (Joint Usage/Research Center) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy17ඹྠ฼⏝࣭ඹྠ◊✲ཷධㄢ㢟 (List of Joint Usage/Research project) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy18୺せ◊✲ᶵჾ࣭タഛ࡟ࡘ࠸࡚ (Research Equipment and Facilities) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy20኱Ꮫ㝔࡟࠾ࡅࡿ◊✲ᣦᑟཬࡧⱝᡭ◊✲⪅ࡢ⫱ᡂ (Promotion of the Young Investigators) yyyyyyyyyyyyyy22┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮⑓ཎ┿⳦ㅮ⩦఍ (The training course of pathogenic fungi) yyyyyyyyyyyyyyyyyyyy23ᅜ㝿஺ὶ༠ᐃ㸦኱Ꮫ㛫஺ὶ༠ᐃ࣭㒊ᒁ㛫஺ὶ༠ᐃ࡞࡝㸧(Inter-University and Faculty-level Exchange Agreements)yyyy24ᅜ㝿ⓗ࡞ඹྠ◊✲ဨཬࡧᏛ⏕ࡢཷධ≧ἣ (Number of International Joint Researchers and Students)yyyyyyyy24㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᣐⅬᾏእᣐⅬ㐃ᦠඹྠ◊✲ (Cooperative Research of Priority Areas with NEKKEN, Nagasaki University)yyy25

AMED/JICA ᆅ⌫つᶍㄢ㢟ᑐᛂᅜ㝿⛉Ꮫᢏ⾡༠ຊࣉࣟࢢ࣒ࣛ yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy25(AMED/JICA Science and Technology Research Partnership for Sustainable Development)㧗㱋⪅࣭᪂⏕ඣ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ไᅽ࡬ྥࡅࡓண㜵࣭デ᩿࣭἞⒪㛤Ⓨࣉࣟࢪ࢙ࢡࢺ yyyyyyyyyyyyyyyyyyyyyy26(Project for the development of preventive, diagnostic and therapeutic measures against aspergillosis in the elderly people and high-risk neonates)ឤᰁ⑕◊✲㠉᪂࢖ࢽࢩ࢔ࢸ࢕ࣈ (Japanese Initiative for Progress of Research on Infectious Disease for Global Epidemic) yyyy 26༓ⴥ኱Ꮫࢢ࣮ࣟࣂࣝࣉ࣑ࣟࢿࣥࢺ◊✲ᇶᖿ࣮ࣜࢹ࢕ࣥࢢ◊✲⫱ᡂࣉࣟࢢ࣒ࣛyyyyyyyyyyyyyyyyyyyyyyyyyyy27(Leading Research Promotion Program, Chiba University)ண⟬≧ἣ (Budget) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy28㐠Ⴀ㸦Administration) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy29࢔ࢡࢭࢫ࣐ࢵࣉ (Location and Access Map) yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy301༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗≉௵ᩍᤵ ➲ᕝ ༓ᑜ      

ࡣࡌࡵ࡟

ᡃࡀᅜࡣ㉸㧗㱋♫఍࡟✺ධࡋࠊ㧗ᗘ་⒪ࡸ⏕ά⩦័⑓࡟㉳ᅉࡋࡓ᪥࿴ぢឤᰁ⑕ࠊ៏ᛶ㛢ሰᛶ⫵⑌ᝈ
㸦COPD㸧ࢆࡣࡌࡵ࡜ࡍࡿ࿧྾ჾ⑓࡟࠾ࡅࡿ┿⳦࣭⣽⳦ឤᰁ⑕ࡣቑຍࡢ୍㏵ࢆ㎺ࡾࠊࡲࡓ⤒῭ࡢࢢ࣮ࣟࣂࣜࢮ࣮ࢩࣙࣥ࡟క࠺㍺ධ┿⳦⑕࡞࡝ࠊ┿⳦⑕ࢆࡣࡌࡵ࡜ࡍࡿࡉࡲࡊࡲ࡞ឤᰁ⑕ࡢ⬣ጾ࡟┤㠃ࡋ࡚࠸ࡲࡍࠋࡇࡢࡼ࠺࡞≧ἣ࡛ࠊᡃࡀᅜ၏୍ࡢ┿⳦⑕ࡢ◊✲࣭ᩍ⫱ᶵ㛵࡜ࡋ࡚ࠊࡲࡓ༓ⴥ኱Ꮫ࡟࠾࠸࡚ࡣࠊ
ឤᰁ⑕࣭ච␿࣭⑓ཎయࡢ◊✲ࣉࣛࢵࢺ࣮࣒࣍࡜ࡋ࡚ࠊᮏࢭࣥࢱ࣮ࡢ౑࿨ࡣ௨๓࡟ࡶቑࡋ࡚㔜せ࡟࡞ࡗ࡚࠸ࡲࡍࠋ ᮏࢭࣥࢱ࣮ࡣࠊ⑓ཎ┿⳦◊✲ࢆ୰ᚰ࡜ࡍࡿឤᰁ⑕࣭ච␿ࢆྵࡴ㡿ᇦࡢඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ࡜ࡋ࡚ࠊᖹᡂ 28 ᖺᗘ࡟ᩥ㒊⛉Ꮫ኱⮧ࡼࡾ෌ㄆᐃࢆཷࡅ⌧ᅾ࡟⮳ࡗ࡚࠸ࡲࡍࠋᮏ◊✲ࢭࣥࢱ࣮ࡣࠊ
ᅜබ⚾❧኱Ꮫཬࡧ◊✲ᶵ㛵ࠊ༓ⴥ኱Ꮫ㛵ಀ㒊ᒁࠊ་⒪ᶵ㛵ࠊ௻ᴗ࡞࡝࡜⥭ᐦ࡟㐃ᦠࡋ࡚ࠊඹྠ฼⏝࣭ඹྠ◊✲ࠊᩍ⫱άືࢆ✚ᴟⓗ࡟⾜ࡗ࡚࠸ࡲࡍࠋᮏࢭࣥࢱ࣮ࡢ⮫ᗋឤᰁ⑕ศ㔝ࢆ୰ᚰ࡜ࡋࡓࢢ࣮ࣝࣉࡣࠊ
᪥ᮏ་⒪㛤Ⓨᶵᵓ㸦AMED㸧࡟ࡼࡿᆅ⌫つᶍㄢ㢟ᑐᛂᅜ㝿⛉Ꮫᢏ⾡༠ຊࣉࣟࢢ࣒ࣛ㸦SATREPS㸧࡟᥇ᢥࡉࢀࠊᖹᡂ 28 ᖺᗘ࠿ࡽࣈࣛࢪ࣭ࣝ࢝ࣥࣆ࣮ࢼࢫ኱Ꮫ་Ꮫ㒊࡜㐃ᦠࡋࠊ⌧ᆅ࡟࠾ࡅࡿ⸆๣⪏ᛶ┿⳦࡟ࡼࡿឤᰁ⑕ࡢᐇែゎ᫂ࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋࡲࡓࠊᩥ㒊⛉Ꮫ┬ࡢࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ㸦NBRP㸧࡜ࡋ࡚ࠊᮏࢭࣥࢱ࣮࡛ࡣࠊ⑓ཎ┿⳦ࡸᨺ⥺⳦ࡢ཰㞟࣭ಖᏑ࣭ࢤࣀ࣒ゎᯒ࣭ศ୚➼ࡢάືࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡉࡽ࡟ࡇࢀࡽࡢ஦ᴗ࡜ᖹ⾜ࡋ࡚ࠊ⊂❧◊✲ࢢ࣮ࣝࣉ࣮ࣜࢲ࣮࡟ࡼࡿᇶ┙◊✲ࢆ᥎㐍ࡋ࡚࠸ࡲࡍࠋ୍᪉ࠊᖹᡂ 26 ᖺ 10 ᭶࡟ࡣ⮫ᗋឤᰁ⑕◊✲ศ㔝ࡀࠊ㝃ᒓ⑓㝔࡟࠾࠸࡚ᡃࡀᅜึࡢ┿⳦⑕ᑓ㛛እ᮶ࢆ㛤タࡋࡲࡋࡓࠋࡲࡓࠊ27 ᖺ 4 ᭶࡟ࡣ㧗ᗘ⑓ཎ┿⳦࡟≉໬ࡋࡓ BSL-3 ᪋タࡀᩚഛࡉࢀࡲࡋࡓࠋ
ࡋࡓࡀࡗ࡚ᮏࢭࣥࢱ࣮࡛ࡣࠊ
ࠕඹྠ฼⏝࣭ඹྠ◊✲࣭ࣂ࢖࢜ࣜࢯ࣮ࢫᣐⅬ஦ᴗࠖࠊࠕឤᰁ⑕࣭ච␿ᇶ┙◊✲ࠖࠊࠕ┿⳦⑕⮫ᗋ◊✲ࠖࡢ୕ࡘࢆᰕ࡜ࡋ࡚ࠊ௒ᚋࡶᡃࡀᅜࡢ┿⳦་ᏛࡢⓎᒎ࡟ඛᑟⓗ࡞ᙺ๭ࢆᯝࡓࡍ
ᡤᏑ࡛ࡍࠋ
Major challenges facing a super-aging society include a rising number of immunocompromised hosts andpatients with pneumonia, particularly in those with chronic obstructive pulmonary disease (COPD). Moreover,the dramatic increase in worldwide trade, which has led to the spread of severe fungal infectious diseases, isbeing recognized as a key issue for the aging population. The Medical Mycology Research Center (MMRC) at
Chiba University has become increasingly important because it serves as a research organization and promotes
educational activities to raise public awareness.
Since 2011, MMRC has been certified as one of the Joint Usage/Research Centers by the Minister of Education,
Culture, Sports, Science and Technology (MEXT). In this capacity, MMRC has been actively engaged in medical
mycology research and its related fields, such as immunology and infectious disease science, throughpartnerships with universities, public institutions, medical institutions, and pharmaceutical companies.
In addition, since 2002, MMRC has been a key institution in the National BioResource Project (NBRP) byadministering a central fungal culture collection. MMRC continues to support research activities by providing
resources to expand the understanding of fungal pathogenesis and host innate immune responses. Furthermore, in
October 2014 a specialty clinical research facility for fungal infections was opened at the Chiba University
Hospital; this facility is the only outpatient clinic for fungal infections in Japan. Importantly, in 2015, MMRC
underwent a 6-year research activity evaluation by MEXT, and received
high commendations including renewed funding support for the next 6 years.
Accordingly, we envision MMRC as the leading scientific research
institution devoted to excellence in microbiology and immunology, clinicalfungal infectious disease research, and providing key resources for researchon pathogenic fungi and actinomycetes, with the ultimate goal of advancing
the field of medical mycology.
2

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᫛࿴21ᖺ 9᭶10᪥
(1946)
᫛࿴24ᖺ 5᭶31᪥
(1949)
᫛࿴48ᖺ 9᭶29᪥
(1973)
᫛࿴52ᖺ10᭶29᪥
(1977)
᫛࿴62ᖺ 5᭶21᪥
(1987)

ᖹᡂ 2ᖺ 4᭶ 1᪥
(1990)
ᖹᡂ 9ᖺ 4᭶ 1᪥
(1997)
ᖹᡂ13ᖺ 4᭶ 1᪥
(2001)
ᖹᡂ16ᖺ 4᭶ 1᪥
(2004)
ᖹᡂ22ᖺ 2᭶ 1᪥
(2010)
ᖹᡂ22ᖺ 4᭶ 1᪥
(2010)
ᖹᡂ28ᖺ 4᭶ 1᪥
(2016)

Historical Chart༓ⴥ་⛉኱Ꮫ㝃ᒓ⭉ᩋ◊✲ᡤࡀタ❧ࡉࢀࡓ㸦⌧ᅾࡢ⩦ᚿ㔝ᕷἨ⏫㸧ࠋThe Institute of Food-Microbiology Chiba Medical College was established.
༓ⴥ኱Ꮫ⭉ᩋ◊✲ᡤ࡜࡞ࡗࡓࠋThe Institute of Food-Microbiology was incorporated into the Chiba University.
⏕≀άᛶ◊✲ᡤ࡟ᨵ⤌ࡉࢀࡓ㸦6◊✲㒊㸧ࠋThe Institute was reorganized to the Research Institute for Chemobiodynamics.
༓ⴥᕷ஻㰯1୎┠8␒1ྕ࡟᪂Ⴀࠊ⛣㌿ࡋࡓࠋ
The new building of the institute was built at 1-8-1 Inohana, Chiba-City.
⏕≀άᛶ◊✲ᡤࡀᗫṆ࣭㌿᥮࡜࡞ࡾࠊ඲ᅜඹྠ฼⏝᪋タ࡜ࡋ࡚┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮㸦2◊✲㒊㛛5ศ㔝㸧ࡀタ⨨ࡉࢀࡓ㸦10ᖺ᫬㝈㸧ࠋThe Institute was reorganized to the Research Center for Pathogenic Fungi
and Microbial Toxicoses and became Nationwide Joint-use Facility.
άᛶᛂ⟅◊✲㒊㛛࡟ࠊ᪂ࡓ࡟స⏝ᶵᵓศ㔝㸦ᐈဨ㸧ࡀタ⨨ࡉࢀࡓࠋ
Division of Mechanisms of Biological Responses was newly founded.
┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮ࡀᗫṆ࣭㌿᥮࡜࡞ࡾࠊ඲ᅜඹྠ฼⏝᪋タ࡜ࡋ࡚┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㸦2◊✲㒊㛛6ศ㔝㸧ࡀタ⨨ࡉࢀࡓ㸦10ᖺ᫬㝈㸧ࠋThe center was reorganized to the Medical Mycology Research Center.
⑓ཎ┿⳦◊✲㒊㛛࡟ࠊ᪂ࡓ࡟┿⳦㈨※㛤Ⓨศ㔝ࡀタ⨨ࡉࢀࡓࠋ
Division of Fungal Resources & Development was newly founded.
ᅜ❧኱Ꮫἲே࡟⛣⾜ࡋࡓࠋ
The Center was transformed into the National University Corporation.
1㒊㛛4ศ㔝࡟ᨵ⤌ࡉࢀࡓࠋThe Center was reorganized into 1 department including 4 research divisions.
ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ(┿⳦ឤᰁ⑕◊✲ᣐⅬ)࡟ㄆᐃ(6ᖺ㛫)ࡉࢀࡓࠋ
The Center was certified for Joint Usage/Research Center (6 years).
ඹྠ฼⏝࣭ඹྠᣐⅬ(┿⳦ឤᰁ⑕ᣐⅬ)࡟෌ㄆᐃ(6ᖺ)ࡉࢀࡓࠋ
The Center was recertified for Joint Usage/Research Center (6 years).

⭉ᩋ◊✲ᡤInstitute of Food-Microbiology⏕≀άᛶ◊✲ᡤResearch Institute for
Chemobiodynamics┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
Medical Mycology
Research CenterṔ௦ᡤ㛗࣭ࢭࣥࢱ࣮㛗
Successive Directors⭉ᩋ◊✲ᡤ (1946㹼1973)
Institute of Food-Microbiology⏕≀άᛶ◊✲ᡤ (1973㹼1987)
Research Institute for
Chemobiodynamics┿᰾ᚤ⏕≀◊✲ࢭࣥࢱ࣮ (1987㹼1997)
Research Center for Pathogenic
Fungi and Microbial Toxicoses┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ (1997㹼)Medical Mycology Research Center3

᫛࿴21ᖺ 9᭶10᪥㹼᫛࿴32ᖺ 5᭶21᪥
᫛࿴32ᖺ 5᭶22᪥㹼᫛࿴38ᖺ 5᭶21᪥
᫛࿴38ᖺ 5᭶22᪥㹼᫛࿴41ᖺ 5᭶21᪥
᫛࿴41ᖺ 5᭶22᪥㹼᫛࿴44ᖺ 5᭶21᪥
᫛࿴44ᖺ 5᭶22᪥㹼᫛࿴48ᖺ 9᭶28᪥
᫛࿴48ᖺ 9᭶29᪥㹼᫛࿴49ᖺ 1᭶ 9᪥᫛࿴49ᖺ 1᭶10᪥㹼᫛࿴49ᖺ 3᭶31᪥
᫛࿴49ᖺ 4᭶ 1᪥㹼᫛࿴53ᖺ 3᭶31᪥
᫛࿴53ᖺ 4᭶ 1᪥㹼᫛࿴57ᖺ 3᭶31᪥
᫛࿴57ᖺ 4᭶ 1᪥㹼᫛࿴61ᖺ 3᭶31᪥
᫛࿴61ᖺ 4᭶ 1᪥㹼᫛࿴62ᖺ 5᭶20᪥
᫛࿴62ᖺ 5᭶21᪥㹼ᖹᡂ 3ᖺ 5᭶20᪥
ᖹᡂ 3ᖺ 5᭶21᪥㹼ᖹᡂ 5ᖺ 5᭶20᪥
ᖹᡂ 5ᖺ 5᭶21᪥㹼ᖹᡂ 9ᖺ 3᭶31᪥
ᖹᡂ 9ᖺ 4᭶ 1᪥㹼ᖹᡂ11ᖺ 3᭶31᪥
ᖹᡂ11ᖺ 4᭶ 1᪥㹼ᖹᡂ17ᖺ 3᭶31᪥
ᖹᡂ17ᖺ 4᭶ 1᪥㹼ᖹᡂ21ᖺ 3᭶31᪥
ᖹᡂ21ᖺ 4᭶ 1᪥㹼ᖹᡂ25ᖺ 3᭶31᪥
ᖹᡂ25ᖺ 4᭶ 1᪥㹼ᑠụ ᩗ஦┦☾ ࿴჆ᐑᮌ 㧗᫂┦☾ ࿴჆ᐑᮌ 㧗᫂ᐑᮌ 㧗᫂┦☾ ࿴჆᪂஭  ṇஂᡃ ဴᮁ᪂஭  ṇஂᡃ ဴᮁᐑ἞  ㄔᑎᑿ  Ύᐑ἞  ㄔᐑ἞  ㄔすᮧ ࿴Ꮚ୕ୖ  〴㔝ᮏ ᫂⏨➲ᕝ ༓ᑜ

Keizi Koike
Kazuyoshi Aiso
Komei Miyagi
Kazuyoshi Aiso
Komei Miyagi
Komei Miyagi
Kazuyoshi Aiso
Tadashi Arai
Tetsuro Kuga
Tadashi Arai
Tetsuro Kuga
Makoto Miyaji
Kiyoshi Terao
Makoto Miyaji
Makoto Miyaji
Kazuko Nishimura
Yuzuru Mikami
Akio Nomoto
Chihiro Sasakawaᶵᵓᅗ ┿⳦⑕◊✲㒊㛛
㻰㼑㼜㼍㼞㼠㼙㼑㼚㼠㻌㼛㼒㻌㻹㼥㼏㼛㼟㼕㼟㻌㻾㼑㼟㼑㼍㼞㼏㼔䝉䞁䝍䞊㛗㻰㼕㼞㼑㼏㼠㼛㼞
ᩍဨ఍㆟㻲㼍㼏㼡㼘㼠㼥㻌
㻹㼑㼑㼠㼕㼚㼓
㐠Ⴀ༠㆟఍㻿㼏㼕㼑㼚㼠㼕㼒㼕㼏㻌㻯㼛㼡㼚㼏㼕㼘

ឤᰁච␿ศ㔝
㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻵㼙㼙㼡㼚㼛㼘㼛㼓㼥ឤᰁᛂ⟅䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻵㼙㼙㼡㼚㼑㻌㻾㼑㼟㼜㼛㼚㼟㼑 㼕㼚㻌㻵㼚㼒㼑㼏㼠㼕㼛㼡㼟㻌㻰㼕㼟㼑㼍㼟㼑㼟䝃䜲䝖䜹䜲䞁䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞 㻯㼥㼠㼛㼗㼕㼚㼑㻌㻾㼑㼟㼑㼍㼞㼏㼔ᚤ⏕≀䞉ච␿ไᚚ䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻴㼛㼟㼠㻙㻹㼕㼏㼞㼛㼎㼕㼍㼘㻌㻵㼚㼠㼑㼞㼍㼏㼠㼕㼛㼚㼟㻌㼕㼚㻌㻿㼥㼙㼎㼕㼛㼟㼕㼟㻌㼍㼚㼐 㻼㼍㼠㼔㼛㼓㼑㼚㼑㼟㼕㼟⑓ཎᶵ⬟ศ㔝
㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻮㼕㼛㼘㼛㼓㼥䜹䞁䝆䝎䝣䜵䝜䞊䝮䝥䝻䝆䜵䜽䝖㻯㼍㼚㼐㼕㼐㼍 㻼㼔㼑㼚㼛㼙㼑 㻼㼞㼛㼖㼑㼏㼠⮫ᗋឤᰁ⑕ศ㔝㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻯㼘㼕㼚㼕㼏㼍㼘㻌㻾㼑㼟㼑㼍㼞㼏㼔⮫ᗋឤᰁ⑕䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼠㼛㻌㻸㼕㼚㼗㻌㻮㼍㼟㼕㼏㻌㻿㼏㼕㼑㼚㼏㼑㼟㻌㼍㼚㼐㻌㻯㼘㼕㼚㼕㼏㼍㼘㻌㻾㼑㼟㼑㼍㼞㼏㼔㼑㼟ឤᰁᐟ୺ᛂ⟅䝛䝑䝖䝽䞊䜽䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻴㼛㼟㼠㻌㻾㼑㼟㼜㼛㼚㼟㼑㻌㻺㼑㼠㼣㼛㼞㼗㻌㼛㼒㻌㻮㼍㼏㼠㼑㼞㼕㼍㼘㻌㻵㼚㼒㼑㼏㼠㼕㼛㼚ศᏊ⣽⬊䝅䜾䝘䝸䞁䜾ゎᯒ䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻹㼛㼘㼑㼏㼡㼘㼍㼞㻌㻿㼕㼓㼚㼍㼘㼕㼚㼓㻌㻭㼚㼍㼘㼥㼟㼕㼟ឤᰁ⑕ไᚚศ㔝㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻵㼚㼒㼑㼏㼠㼕㼛㼚㻌㻯㼛㼚㼠㼞㼛㼘㻌㼍㼚㼐㻌㻼㼞㼑㼢㼑㼚㼠㼕㼛㼚ឤᰁ⑕ไᚚ䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼠㼛㻌㻸㼕㼚㼗㻌㻵㼚㼒㼑㼏㼠㼕㼛㼚㻌㻯㼛㼚㼠㼞㼛㼘㻌㼍㼚㼐㻌㻼㼞㼑㼢㼑㼚㼠㼕㼛㼚㻾㻺㻭ឤᰁ἞⒪Ꮫศ㔝㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻾㻺㻭㻌㼀㼔㼑㼞㼍㼜㼥㻾㻺㻭ไᚚ䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻾㻺㻭㻌㻾㼑㼓㼡㼘㼍㼠㼕㼛㼚ᚤ⏕≀㈨※ศ㔝㻰㼕㼢㼕㼟㼕㼛㼚㻌㼛㼒㻌㻮㼕㼛㻙㼞㼑㼟㼛㼡㼞㼏㼑㼟ᚤ⏕≀๰⏕䝥䝻䝆䜵䜽䝖㻼㼞㼛㼖㼑㼏㼠㻌㼒㼛㼞㻌㻿㼥㼟㼠㼑㼙㼟㻌㻮㼕㼛㼘㼛㼓㼥㻌㼛㼒㻌㻹㼕㼏㼞㼛㼛㼞㼓㼍㼚㼕㼟㼙㼟䝞䜲䜸䝸䝋䞊䝇⟶⌮ᐊ㻹㼍㼚㼍㼓㼑㼙㼑㼚㼠㻌㼁㼚㼕㼠 㼛㼒㻌㻹㼕㼏㼞㼛㼎㼕㼛㼘㼛㼓㼕㼏㼍㼘㻌㻾㼑㼟㼛㼡㼞㼏㼑㼟4┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ឤᰁච␿ศ㔝 (Division of Molecular Immunology)⡿ᒣ ගಇ㸦ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Mitsutoshi Yoneyama (Professor)኱㜰኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ಟ஢ࠋ㸦㈈㸧ᮾி㒔⮫ᗋ་Ꮫ⥲ྜ◊✲ᡤ㸦⌧࣭ᮾி㒔་Ꮫ◊㸧ࠊி㒔኱Ꮫ࢘࢖ࣝ
ࢫ◊✲ᡤࢆ⤒࡚ࠊ2010 ᖺࡼࡾ⌧⫋ࠋ༓ⴥ኱Ꮫࢢ࣮ࣟ
ࣂࣝࣉ࣑ࣟࢿࣥࢺ◊✲ᇶᖿ࣮ࣜࢹ࢕ࣥࢢ◊✲⫱ᡂࣉࣟࢢ࣒ࣛࠕ㉸ಶయ͇ࡢ⤫ྜⓗ⌮ゎ࡟ᇶ࡙ࡃḟୡ௦ᆺࠕឤ
ᰁไᚚᏛࠖ◊✲᥎㐍ᣐⅬࠖ᥎㐍㈐௵⪅ឤᰁᛂ⟅ࣉࣟࢪ࢙ࢡࢺ
Project for Immune Response in Infectious Diseases

ᴫせ (Abstract) 㻌 ឤᰁ࡟ᑐࡍࡿᡃࠎࡢ⏕య㜵ᚚࡣࠊ⮬↛ච␿࡜⋓ᚓච␿࡟ࡼࡗ࡚༠ㄪ
ࡋ࡚⾜ࢃࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࢘࢖ࣝࢫឤᰁ࡟ᛂ⟅ࡋࡓ⮬↛ච␿ㄏᑟ࡟ὀ┠ࡋࠊឤᰁࢭࣥࢧ࣮ศᏊ࡟ࡼࡿ࢘࢖ࣝࢫ⏤᮶ࡢ㠀⮬ᕫ᰾㓟᳨▱ࡢศᏊᶵᵓࡢゎ᫂࡜ࠊࡑࢀ࡟ࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿච␿ᛂ⟅ࡢ⏕⌮ᶵ⬟ࢆゎᯒࡍࡿࡇ࡜࡟ࡼࡾࠊ࢘࢖ࣝࢫឤᰁ⑕࡟ᑐࡍࡿ᪂ࡓ࡞἞⒪ᡓ␎ࡢ㛤Ⓨࢆ┠ᣦࡋࡓゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ㻌 㻌
Innate immune system plays an essential role for self-defense
against infection of a variety of pathogens. We focus on antiviral
innate immunity, especially molecular machinery for detection ofviral infection and subsequent immune responses. The observations obtained from the studies will help us
to establish a novel therapeutic or preventive strategy against infectious diseases.
୺࡞ࢸ࣮࣐ (Research Focus)1) ࢘࢖ࣝࢫࢭࣥࢧ࣮RIG-I-like receptor (RLR)࡟ࡼࡿ࢘࢖ࣝࢫ⏤᮶㠀⮬ᕫRNAࡢㄆ㆑ࡢศᏊᶵᵓࡢゎ᫂㻌2) RLRࢆ௓ࡋࡓࢩࢢࢼࣝࡢ⏕⌮ᶵ⬟ࡢゎ᫂㻌3) ᐟ୺࡟ࡼࡿ࢘࢖ࣝࢫឤᰁᛂ⟅࡜ࢫࢺࣞࢫᛂ⟅ࡢ┦஫స⏝ࡢゎᯒ1) Molecular mechanism underlying detection of viral non-self RNA by RIG-I-like receptors (RLRs)
2) Studies on physiological significance of RLR-mediated signaling3) Interaction between host innate immunity and stress responses
᭱㏆ࡢᴗ⦼ (Recent Publications)1) Yoneyama et al., J. Biochem., 159, 279-286, 2016.
2) Yoneyama et al., Curr.Opin. Immunol., 32, 48-53, 2015.
3) Onomoto et al., Trends Immunol., 35, 420-28, 2014.
4) Onomoto et al., PLoS One, 7, e43031, 2012.
◊✲ࢫࢱࢵࣇ
ຓᩍ㻌㻌ᢏ⾡⫋ဨ㻌ᢏ⾡⿵బဨ㻌

ᑿ㔝ᮏ㻌 ᾈྖ㻌ᖖ႐㻌 ൲ᙪ㻌⁪ἑ㻌 ࡳࡺࡁ㻌(Staff)Assistant Professor
Research Technician
Research Promotion Technician

Koji Onomoto
Michihiko Jogi
Miyuki Takizawa

Lab
LabURL
URL http://www.pf.chiba-u.ac.jp/project_immuneresponses/
http://www.pf.chiba-u.ac.jp/project_immuneresponses/5┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ឤᰁච␿ศ㔝 (Division of Molecular Immunology)すᇛ ᚸ㸦෸ᩍᤵ࣭PI㸧
Shinobu Saijo (Associate Professor)
2010 ᖺ 10 ᭶ࡼࡾ⌧⫋ࠋ๓௵ᆅࡢᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤ᫬௦࠿ࡽࠊಶయ࡛ࣞ࣋ࣝ⅖⑕ᛶ⑌ᝈⓎ⑕ᶵᵓࡢゎ᫂ࠊ⏕యᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

ࢧ࢖ࢺ࢝࢖ࣥࣉࣟࢪ࢙ࢡࢺ
Project for Cytokine Researchᴫせ (Abstract) ⏕యࡣࠊከ✀ከᵝ࡞⣽⬊ࡸ⤌⧊ࡀ஫࠸࡟᫬✵ⓗ࡟స⏝ࡍࡿࡇ࡜࡟ࡼࡾᜏᖖᛶࡀ⥔ᣢࡉࢀࡿ୍ࡘࢩࢫࢸ࣒࡛࠶ࡾࠊ
ࡑࡢ⥔ᣢ࡟࠾࠸࡚ࢧ࢖ࢺ࢝࢖ࣥࡣ୰ᚰⓗ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࠋከࡃࡢ⑌⑓ࡣ༢࡟୍ࡘࡢ⮚ჾࠊ⤌⧊ࡢ␗ᖖ࡛ࡣ࡞
ࡃࠊච␿⣔ࢆጞࡵ࡜ࡍࡿ✀ࠎࡢࢩࢫࢸ࣒ࡢ␗ᖖ࡛࠶ࡿࡇ࡜࠿ࡽࠊ
ࡇࢀࡽࢆ⤫ྜࡍࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࢆ▱ࡿࡇ࡜ࡣ㠀ᖖ࡟㔜せ࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊឤᰁᛶ⑌ᝈࡸ⅖⑕ᛶ⑌ᝈࡢ⑓ែ
ᙧᡂ࡟࠾ࡅࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࢆゎ᫂ࡋࠊ᭱⤊ⓗ࡟᪂ࡓ࡞἞⒪⸆ࡢᶆⓗศᏊࢆぢฟࡍࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
Cytokines play a central role in maintenance of
homeostasis. Development of transgenic techniques has
made it possible to directly analyze the functions of aparticular gene in a living animal. We aim to find newtherapeutic targets for inflammatory diseases and infectious
diseases by investigating the roles of cytokines inpathogenesis using transgenic techniques.
୺࡞ࢸ࣮࣐ (Research Focus) ࢧ࢖ࢺ࢝࢖ࣥࡢ⏘⏕ᶵᵓ࡜ࡑࡢ⏕⌮ᶵ⬟ࡢゎ᫂ࢆ┠ⓗ࡜ࡋࠊಶయ࡛ࣞ࣋ࣝࡢゎᯒࢆ⾜࠺ࠋ1) ࢧ࢖ࢺ࢝࢖ࣥ࡟ࡼࡿච␿ᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂2) ┿⳦࡟ࡼࡗ࡚ㄏᑟࡉࢀࡿࢧ࢖ࢺ࢝࢖ࣥ࡜ࡑࡢឤᰁ㜵ᚚ࡟࠾ࡅࡿᙺ๭ࡢゎ᫂3) ⮬ᕫච␿⑌ᝈࠊ࢔ࣞࣝࢠ࣮ᛶ⑌ᝈࡢ⑓ែᙧᡂ࡟࠾ࡅࡿࢧ࢖ࢺ࢝࢖ࣥࡢᙺ๭ࡢゎ᫂
Using gene-deficient mice, we are investigating the mechanisms of cytokine production and their roles in thedevelopment of infectious and inflammatory diseases.
1) Elucidation of the roles of cytokines in the maintenance of immune homeostasis.
2) Elucidation of the roles of cytokines induced by fungal infection.
3) Elucidation of the roles of cytokines in the pathogenesis of inflammatory diseases.
◊✲ࢫࢱࢵࣇ
ຓᩍ
ᢏ⾡⿵బဨ
ᢏ⾡⿵బဨ
Lab URLLab URL▮㒊 ຊᮁᓠ  ⰋᏊ㕥ᮌ ᬛ᫂

(Staff)Assistant Professor
Research Promotion Technician
Research Promotion Technician

Rikio Yabe
Ryoko Mine
Tomoaki Suzuki

http://cytokine.pf.chiba-u.jp/
http://cytokine.pf.chiba-u.jp/6┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ឤᰁච␿ศ㔝 (Division of Molecular Immunology)ᚋ⸨ ⩏ᖾ㸦෸ᩍᤵ࣭PI㸧
Yoshiyuki Goto (Associate Professor)ᮾ໭኱Ꮫ༞ᴗᚋࠊᮾி኱Ꮫ኱Ꮫ㝔་Ꮫ⣔◊✲⛉༤ኈㄢ⛬ಟ஢ࠊᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤ༤ኈ◊✲ဨࢆ⤒࡚ࢥࣟࣥࣅ࢔኱Ꮫᚤ⏕≀࣭ච␿㒊㛛࡟␃Ꮫࠋᖐᅜᚋࠊᮾி኱
Ꮫ་⛉Ꮫ◊✲ᡤᅜ㝿⢓⭷࣡ࢡࢳࣥ㛤Ⓨ◊✲ࢭࣥࢱ࣮≉௵෸ᩍᤵࢆ⤒࡚2015ᖺ6᭶ࡼࡾ⌧⫋ࠋᚤ⏕≀࣭ච␿ไᚚࣉࣟࢪ࢙ࢡࢺ
Project for Host-Microbial Interactions in Symbiosis and Pathogenesisᴫせ (Abstract)ࣄࢺࢆྵࡴከࡃࡢ⏕≀ࡢ⭠⟶ෆ࡟ࡣࠊ↓ᩘࡢᚤ⏕≀ࡀ⏕ᜥࡋ࡚࠾ࡾࠊᐟ୺
࡜ᖹ࿴ⓗ࡞ඹ⏕㛵ಀࢆᵓ⠏ࡋ࡚࠸ࡿࠋࡇࡢඹ⏕㛵ಀࡀᔂࢀࡿ࡜ࠊࢡ࣮ࣟࣥ⑓
ࡸ₽⒆ᛶ኱⭠⅖࡜࠸ࡗࡓ⅖⑕ᛶ⭠⑌ᝈࠊឤᰁ⑕ࠊ࢔ࣞࣝࢠ࣮⑌ᝈࠊ⫧‶ࡸ⢾ᒀ⑓ࢆࡣࡌࡵ࡜ࡍࡿ⏕ά⩦័⑓ࠊ኱⭠࢞ࣥ࡞࡝ࡢᵝࠎ࡞⑌ᝈⓎ⑕ࡢᘬࡁ㔠࡜࡞ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊᐟ୺ࡢ⑓ែࠊ≉࡟⑓ཎᛶ┿⳦ࢆࡣࡌࡵ࡜ࡍࡿ⑓
ཎయࡢឤᰁ⑕࡟ᑐࡍࡿ᭷┈࡞⭠ෆ⣽⳦ࢆྠᐃ࣭༢㞳ࡋࠊᐟ୺ࡢ⑓ែไᚚᶵᵓ
࡟ࡘ࠸࡚◊✲ࢆ⾜࠺ࡇ࡜࡛⭠⟶࡟࠾࠸࡚ほᐹࡉࢀࡿࠕඹ⏕ࠖ࡜ࠕ⑓ែᙧᡂࠖ
ࡢࢩࢫࢸ࣒ࡢゎ᫂ࢆ┠ᣦࡍࠋ↓⳦࣐࢘ࢫ᪋タ

Almost all of the organisms including human have countless numbers of microorganisms in the intestine.
These microorganisms create peaceful relationship with their host. Disruption of these symbiotic system
predispose to the development of human diseases such as inflammatory bowel diseases including Crohn’sdisease and ulcerative colitis, pathogenic infection, allergic diseases, metabolic syndrome such as obesityand diabetes, and colonic cancer. In this project, we identify and isolate beneficial commensal bacteria which
prevent host pathogenesis including infection of pathogenic microorganisms, especially pathogenic fungi.
Our goal is to uncover the system of “symbiosis” and “pathogenesis” created in our intestine.
୺࡞ࢸ࣮࣐ (Research Focus)1) ⭠⟶ୖ⓶⣽⬊ࡢD1, 2-ࣇࢥ࣮ࢫㄏᑟ࣭ไᚚᶵᵓࡢゎ᫂2) ⭠ෆ⣽⳦ྀࡢᨩ஘㸦dysbiosis㸧࡜ᐟ୺⑓ែࡢ㛵ಀ3) ⭠ෆ⣽⳦࣭┿⳦࡜ච␿⣽⬊࡟ࡼࡿ⭠⟶ୖ⓶ᖿ⣽⬊ࡢᶵ⬟ไᚚ4) ឤᰁ⑕࡞࡝ᐟ୺⑓ែࢆไᚚࡍࡿ⭠ෆ⣽⳦ࡢྠᐃ࡜༢㞳1) Identify the mechanism of the induction and regulation of D1, 2-fucose on
the intestinal epithelium2) Uncover how dysbiosis influence on the development of host pathogenesis᎘Ẽᇵ㣴⿦⨨
3) Regulation of intestinal epithelial stem cells by commensal
microorganisms and immune cells4) Identify and isolation of commensal bacteria which prevent host pathogenesis including infection◊✲ࢫࢱࢵࣇ
ᢏ⾡⿵బဨ 㧗ᮌ ᘯᏊᢏ⾡⿵బဨ ኱࿴ 㯞Ꮚ
Lab URLLab URL
7(Staff)Research Promotion Technician
Research Promotion Technician

http://www.pf.chiba-u.ac.jp/project_symbiosis/ 
http://www.pf.chiba-u.ac.jp/project_symbiosis/

Hiroko Takagi
Asako Yamato┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
⑓ཎᶵ⬟ศ㔝 (Division of Molecular Biology)▱ⰼ ༤἞㸦෸ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Hiroji Chibana (Associate Professor)⌰⌫኱Ꮫ༞ᴗࠊྠ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ಟኈㄢ⛬ಟ஢ࠊྡྂᒇ኱Ꮫ་Ꮫ◊✲⛉༤ኈㄢ⛬㸦་┿⳦Ꮫᑓᨷ㸧ಟ஢࡞ࡽࡧ࡟༤ኈ㸦་Ꮫ㸧ྲྀᚓࠋ௨ᚋࠊ⡿ᅜ࣑ࢿࢯࢱᕞ❧኱ᏛศᏊ㑇ఏᏛ⛉ࠊ6 ᖺ㛫ࡢ࣏ࢫࢻࢡࢆ⤒࡚ 2001 ᖺᗘࡼࡾ⌧⫋ࠋ

࢝ࣥࢪࢲࣇ࢙ࣀ࣮࣒ࣉࣟࢪ࢙ࢡࢺ
Candida Phenome Projectᴫせ (Abstract)࢝ࣥࢪࢲ⑕ཎᅉ⳦ࡢ࠺ࡕࠊ࢝ࣥࢪࢲ࣭ࢢࣛࣈ࣮ࣛࢱࡣ⑕౛ᩘࡀቑຍࡋ࡚࠾ࡾࠊ≉࡟㔜せ࡞◊✲ᑐ㇟࡜࡞ࡗ࡚࠸
ࡿࠋᙜ◊✲ᐊ࡛ࡣ㸪࢝ࣥࢪࢲ࣭ࢢࣛࣈ࣮ࣛࢱࡢ⣙ 5 ༓㑇ఏᏊ࡟ᑐࡍࡿ⥙⨶ⓗ⤌᥮࠼యࣛ࢖ࣈ࣮ࣛࣜࢆಶูୟࡘయ
⣔ⓗ࡟ᵓ⠏ࡋࠊ⑓ཎᛶࡢ◊✲࡜᪂ࡋ࠸ᢠ┿⳦⸆㛤Ⓨࢆࡵࡊࡋ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋ
In the pathogenic Candida species, C. glabrata is particularly coming important subject, because thenumber of clinical cases is increasing. We have constructed mutants for the genome including 5000 genes
individually and systematically. Our aim is to understand pathogenicity and control of the fungus followedby the studies of virulence factors toward development of new anti-fungal drug using the mutant library.
୺࡞ࢸ࣮࣐1) 㑇ఏᏊ⤌᥮࠼యࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸ࡓ⑓ཎᅉᏊࡢ⥙⨶ⓗ◊✲ Studies for virulence factors using the mutant
library2) 㑇ఏᏊ⤌᥮࠼ᰴࢆ⏝࠸ࡓᢠ┿⳦⸆ࡢᶆⓗ᥈⣴
Explanatory studies of anti-fungal drug targets using
the mutant library3) ᢠ┿⳦๰⸆ࢩ࣮ࢬࡢ᥈⣴  Discovery of new anti-fungal drug seeds◊✲ࢫࢱࢵࣇᢏ⾡⫋ဨ㧗ᶫ㸦୰ཱྀ㸧ᱻ≉௵ຓᩍబ⸨㸦ᒸᮏ㸧⨾ᬛ௦ࢢࣛࣥࢻࣇ࢙࣮ࣟ ᒣཱྀ ṇどᢏ⾡⿵బဨ኱ᒾ ┿⌮
㠀ᖖ໅ㅮᖌ
Ᏹ㔝 ₶
㠀ᖖ໅ㅮᖌ
బ㔝 ᩥᏊ㠀ᖖ໅ㅮᖌሯཎ ṇಇ㠀ᖖ໅ㅮᖌ⚄ᓮ ⚽Ⴙ

Lab URLLab URL(Staff)Research Technician.
Research Assistant Professor
Grand Fellow
Research Promotion Technician
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer

Azusa Takahashi-Nakaguchi
Michiyo Sato-Okamoto
Mashashi Yamaguchi
Mari Ohiwa
Jun UnoYayako Sano
Masatoshi Tsukahara
Hidetsugu Kozaki,

http://www.pf.chiba-u.ac.jp/bunya_byougenkinou.html
http://www pf chiba-u ac jp/bunya byougenkinou html
8┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
⮫ᗋឤᰁ⑕ศ㔝 (Division of Clinical Research)ட஭ ඞᙪ㸦ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Katsuhiko Kamei (Professor)༓ⴥ኱་Ꮫ㒊༞ᴗᚋࠊᮾி㒔❧ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮㸪බ❧᫛࿴⑓㝔࿧྾ჾෆ⛉࡞࡝ࡢ໅ົࡢᚋ㸪༓ⴥ኱Ꮫ་
Ꮫ㒊࿧྾ჾෆ⛉ຓᡭࠋStanford ኱Ꮫឤᰁ⑕ෆ⛉ࠊᮾⰪ⑓㝔࿧྾ჾෆ⛉ࢆ⤒࡚ࠊ2003 ᖺᗘࡼࡾ⌧⫋㹿ᇶ♏࡜⮫ᗋࡢ୧㠃࠿ࡽ┿⳦⑕ࡢไᅽࢆ┠ᣦࡍ㹿⮫ᗋឤᰁ⑕ࣉࣟࢪ࢙ࢡࢺ
Project to Link Basic Sciences and Clinical Researchesᴫせ (Abstract) ་Ꮫ㒊㝃ᒓ⑓㝔ࡢ┿⳦⑕ᑓ㛛እ᮶࡟᪊࠸࡚῝ᅾᛶ┿⳦⑕ࡢデ⒪ࢆ⾜࠺࡜࡜ࡶ࡟㸪ᡃࡀᅜ࡟࠾ࡅࡿ┿⳦⑕ࣜࣇ࢓ࣞࣥࢫࢭ
ࣥࢱ࣮㸦㍺ධ┿⳦⑕ࢆྵࡴ㸧࡜ࡋ࡚άືࡋ࡚࠾ࡾ㸪඲ᅜࡢ་⒪ᶵ㛵࠿ࡽ┿⳦⑕ࡢࢥࣥࢧࣝࢸ࣮ࢩࣙࣥࡸ୍⯡་⒪᪋タ࡛ࡣᐇ᪋ᅔ㞴࡞≉Ṧ᳨ᰝ࡞࡝ࢆཷࡅධࢀ࡚࠸ࡿࠋ
ࡇࢀࡽࡢ௳ᩘࡣࣂ࢖࢜ࣜࢯ࣮ࢫ⟶⌮ᐊ࡜ྜࢃࡏᖺ 600 ௳࠶ࡲࡾ࡟㐩ࡋ࡚࠸ࡿ㹿◊✲㠃࡛ࡣୖグࡢάືࢆ㏻ࡌࡓ⮫ᗋ◊✲࡟ຍ࠼࡚ࠊBedside to bench to bedside ࡢ᪉㔪࡟ᇶ࡙ࡃ◊✲ࢆ㐙⾜ࡋ࡚࠸ࡿ㹿≉࡟㸪᭱ࡶ῝้࡞㞴἞ᛶ῝ᅾᛶ┿⳦⑕࡛࠶ࡿ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࢆᙜ㠃ࡢ᭱኱ࡢ┠ᶆ࡜ࡋࡘࡘࠊ┿⳦ࡀேయ࡟౵ධࡍࡿឤᰁᶵᵓࡸ㸪㏆ᖺ㢧ᅾ໬ࡋ࡚ࡁࡓ⪏ᛶ⳦ࡢ␿Ꮫࡸ⪏ᛶᶵᵓࡢゎ᫂➼ࢆ㏻ࡋ࡚㺂᪂ࡋ࠸デ᩿ࡸ἞⒪ࡢ㛤Ⓨ࡟ຊࢆධࢀ࡚࠸ࡿࠋ
Our research focuses on the development of diagnostic/therapeutic methods for intractable fungal diseases
such as aspergillosis through an investigation into the mechanism of infection. We also take care of patients inthe outpatient clinic of the University Hospital, while providing consulting services/examinations on fungal
diseases on request from physicians/clinical technologists all over the country.
୺࡞ࢸ࣮࣐ (Research Focus)1) ࢔ࢫ࣌ࣝࢠࣝࢫ⑕࡞࡝ࡢ㞴἞ᛶ┿⳦ឤᰁ⑕ࡢឤᰁᶵᵓ࣭⑓ែ㸦⑓ീ㸧ࡢゎ᫂The pathogenesis of intractable mycoses such as aspergillosis, including the virulence factors.
2) ⪏ᛶ⳦ࡢ␿Ꮫཬࡧᶵᗎ
Epidemiology of resistant fungi and the mechanism of resistance.
3) 㞴἞ᛶ┿⳦⑕ࡢデ᩿࣭἞⒪ἲࡢ㛤Ⓨ
Development of diagnostic methods for intractable deep-seated mycoses.
4) ㍺ධ┿⳦⑕ࡢ␿Ꮫ
Epidemiology of endemic mycoses◊✲ࢫࢱࢵࣇ ෸ᩍᤵ 
Ώ㑓  ဴ≉௵ຓᩍᮧ㛗 ಖ᠇
≉௵ຓᩍ
ⴗཎ ኱♸
≉௵ຓᩍ
᪂ᒃ 㕲ᖹ
ᐈဨᩍᤵᕝᮏ  㐍ᢏ⾡⫋ဨ㙑⏣ 㡪Ꮚᢏ⾡⿵బဨ஭ୖ ிᏊᢏ⾡⿵బဨඵᑜ ┿ᕼᢏ⾡⿵బဨ㛵  㔛ள
ᢏ⾡⿵బဨ
ᅵᒇ⏤⣖Ꮚ
㠀ᖖ໅ㅮᖌ
ᮾỤ ᫛ኵ㠀ᖖ໅ㅮᖌஂ⡿  ග㠀ᖖ໅ㅮᖌ῰㇂ ࿴ಇ㠀ᖖ໅ㅮᖌᐑ㷂 ⩏⥅
㠀ᖖ໅ㅮᖌ‶ᒣ 㡰୍㠀ᖖ໅ㅮᖌ㇏␃ Ꮥோ㠀ᖖ໅ㅮᖌΎỈ බᚨ
㠀ᖖ໅ᢏ⾡⫋ဨ ୕ᾆ  ᝴ࢢࣛࣥࢻࣇ࢙࣮ࣟ ⏣ཱྀ ⱥ᫛(Staff)
Associate Professor
Research Assistant Professor
Research Assistant Professor
Research Assistant Professor
Guest Professor࣭Grand Fellow
Research Technician
Research Promotion Technician
Research Promotion Technician
Research Promotion Technician
Research Promotion Technician
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Visiting Lecturer
Adjunct Research Technician
Grand Fellow

Lab
URL
Lab
URL http://www.pf.chiba-u.ac.jp/bunya_rinsyoukansensyou/
http://www.pf.chiba-u.ac.jp/bunya_rinsyoukansensyou/
9

Akira Watanabe
Yasunori Muraosa
Daisuke Hagiwara
Teppei Arai
Susumu Kawamoto
Kyoko Yarita
Kyoko Inoue
Maki Yahiro
Rio Seki
Yukiko Tsuchiya
Akio Toh-e
Hikaru Kume
Kazutoshi Shibuya
Yoshitsugu Miyazaki
Jun-ichi Mitsuyama
Takahito Toyotome
Kiminori Shimizu
Satoshi Miura
Hideaki Taguchiᒣᮏ ཭Ꮚ㸦≉௵ᩍᤵ㸧

Tomoko Yamamoto (Professor)఍ὠⱝᯇᕷฟ㌟ࠋ༓ⴥ኱Ꮫ⸆Ꮫ㒊༞ᴗࠊ༓ⴥ኱Ꮫ
኱Ꮫ㝔⸆Ꮫ◊✲⛉ಟኈㄢ⛬ಟ஢ࠋ⸆Ꮫ༤ኈ࣭་Ꮫ
༤ኈࠋ༓ⴥ኱Ꮫ⸆Ꮫ㒊㸦ຓᡭ㸧ࠊ⡿ᅜࣘࢱ኱Ꮫ་
Ꮫ㒊㸦Visiting Assistant Professor㸧ࠊᮥᯘ኱Ꮫ
་Ꮫ㒊㸦ຓᩍᤵ㸧ࠊ༓ⴥ኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲㝔㸦ᩍᤵ㸧ࢆ⤒࡚ 2015 ᖺᐃᖺ㏥⫋㸦༓ⴥ኱Ꮫྡ㄃ᩍᤵ㸧2011 ᖺ᪥ᮏ⣽⳦Ꮫ఍ὸᕝ㈹ཷ㈹ឤᰁᐟ୺ᛂ⟅ࢿࢵࢺ࣮࣡ࢡࣉࣟࢪ࢙ࢡࢺ
Project for Host Response Network of Bacterial Infectionᴫせཬࡧ◊✲ࢸ࣮࣐ (Abstract, Research Focus) ࢧࣝࣔࢿࣛᒓ⣽⳦ࢆࣔࢹࣝ࡟ࠊ㣗⣽⬊ෆᐤ⏕ᛶࢆ᭷ࡍࡿ⑓ཎ⣽⳦ࡢ඲㌟ឤᰁ⑕Ⓨ⑕ᶵᗎ୪ࡧ࡟ᣢ⥆ឤᰁᶵᵓࡢゎ᫂ࢆ┠ⓗ࡜ࡋ࡚ୗグࡢ◊✲ࢆ⾜࠺ࠋ1) ⑓ཎศᏊ㸦࢚ࣇ࢙ࢡࢱ࣮㸧࡜ᐟ୺㧗ḟᶵ⬟ࡢ┦஫స⏝࡟ᇶ࡙ࡃࢧࣝࣔࢿࣛ඲㌟ឤᰁᶵᵓࡢゎ᫂2) ឤᰁᐟ୺ࡢච␿グ᠈ᙧᡂࢆక࠺ࢧࣝࣔࢿࣛᣢ⥆ឤᰁᶵᵓࡢゎ᫂3) ࣉࣟࣂ࢖࢜ࢸ࢕ࢡࢫస⏝࡟ࡼࡿࢧࣝࣔࢿࣛឤᰁ⑕㜵ᚚࡢศᏊᶵᵓ
ࡲࡓࠊ⫵⅖⌫⳦࣭ࣈࢻ࢘⌫⳦ࡢ᪂ᆺ⸆๣⪏ᛶᶵᵓ࡟㛵ࡍࡿ◊✲ࢆ⾜࠺ࠋ
Our research goals are dissecting the molecular mechanisms of systemic infection and persistentinfection by facultative intracellular bacteria through the study of Salmonella-host interplay. To attain thegoals, we will focus on yet-uncharacterized Salmonella effectors to elucidate the dynamic interplay with
their host targets and bacterial strategies for withstanding the host innate- and acquired-immune systems.

ᕝᮏ 㐍㸦ᐈဨᩍᤵ࣭ࢢࣛࣥࢻࣇ࢙࣮ࣟ㸧Susumu Kawamoto (Guest Professor㺃Grand Fellow)
ᶓ὾ฟ㌟ࠋி㒔኱Ꮫ༞ᴗࠊி㒔኱኱Ꮫ㝔ᕤᏛ◊✲⛉㸦⏕໬Ꮫ㸧ಟ஢ࠋ༓ⴥ኱་Ꮫ㒊㸦➨஧⏕໬Ꮫ㸧ࠊ⡿ᅜ Case
Western Reserve Universityࠊᖇி኱་Ꮫ㒊ࠊ⡿ᅜ
University of California-San Diego (Visiting
Assistant Professor)ࠊᶓ὾ᕷ኱་Ꮫ㒊ࢆ⤒࡚ࠊ2004┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ᩍᤵࠊ2015 ᖺࡼࡾ⌧⫋ࠋᶓ὾ᕷ኱་Ꮫ㒊ᐈဨᩍᤵࠋ᪥ᮏ་┿⳦Ꮫ఍㈹ཷ㈹㸦2014㸧ศᏊ⣽⬊ࢩࢢࢼࣜࣥࢢゎᯒࣉࣟࢪ࢙ࢡࢺ
Project for Molecular Signaling Analysis
ᴫせཬࡧ◊✲ࢸ࣮࣐ (Abstract, Research Focus)⏕໬Ꮫ࣭ศᏊ⏕≀Ꮫ࣭⣽⬊⏕≀Ꮫ➼ࡢᡭἲࢆ⏝࠸ࠊ⑓ཎ┿⳦㸦Cryptococcus neoformansࠊCryptococcus gattii,
Aspergillus fumigatus ➼㸧ࡢศᏊ⣽⬊◊✲ࢆ⾜࠸ࠊ┿⳦⑕ࡢไᚚ࡟ྥࡅࡓศᏊ⣽⬊་┿⳦Ꮫ࡬ࡢ㈉⊩ࢆ┠ᣦࡍࠋ1) Cryptococcus neoformans ࡢ⣽⬊࿘ᮇ࣭ప㓟⣲ࢫࢺࣞࢫ࣭୰ᯡ⚄⤒ぶ࿴ᛶ࣭ࢸ࣓࣮ࣟࣛࢮࡢ⌮ゎ࡟ྥࡅ࡚2) ⑓ཎ┿⳦࡟࠾ࡅࡿ୍㓟໬❅⣲㸦NO㸧ࡢ⏕ྜᡂ࣭⏕⌮ᶵ⬟ゎᯒ3) ࣐࢖ࢥ࢘࢖ࣝࢫࢱࣥࣃࢡ㉁ࡢస⏝ᶵᗎゎᯒ
We are conducting basic research on the molecular and cellular biology of pathogenic fungi (Cryptococcus
neoformans, Cryptococcus gattii, Aspergillus fumigatus) using biochemistry and molecular biology methods.
1) Towards understanding cell cycle regulation, hypoxic adaptation, CNS-tropism and telomerase
in Cryptococcus neoformans.
2) Analysis of biosynthesis and physiological function of nitric oxide (NO) in pathogenic fungi.
3) Molecular and functional analysis of mycoviral protein.
10┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ឤᰁ⑕ไᚚศ㔝 (Division of Infection Control and Prevention)▼࿴⏣ ⛱ᙪ㸦෸ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Naruhiko Ishiwada (Associate Professor)༓ⴥ኱Ꮫ་Ꮫ㒊༞ᴗᚋࠊ༓ⴥ኱Ꮫ་Ꮫ㒊㝃ᒓ⑓㝔ᑠඣ⛉ࠊ༓ⴥ┴ࡇ࡝ࡶ⑓㝔ឤᰁ⑕⛉➼໅ົࠊJICA ࣮࢞ࢼឤᰁ⑕ᑐ⟇ࣉࣟࢪ࢙ࢡࢺ㛗ᮇᑓ㛛ᐙ㸦1999㹼2001 ᖺ㸧ࠊ2014 ᖺࡼࡾ⌧⫋ࠋ᪥ᮏᑠඣ⛉Ꮫ఍ᑓ㛛་ࠊ᪥ᮏឤᰁ
⑕Ꮫ఍ᑓ㛛་࣭ᣦᑟ་

ឤᰁ⑕ไᚚࣉࣟࢪ࢙ࢡࢺ
Project for Infection Control and Prevention
ᴫせ (Abstract) ࢖ࣥࣇ࢚ࣝࣥࢨ⳦ࠊ⫵⅖⌫⳦ࠊB ⩌ࣞࣥࢧ⌫⳦㸦GBS㸧ࡢ⑓ཎᛶゎᯒ࡞ࡽࡧ࡟࢖ࣥࣇ࢚ࣝࣥࢨ⳦ឤᰁ⑕࡜⫵⅖
⌫⳦ឤᰁ⑕ࠊGBS ឤᰁ⑕ࡢ␿Ꮫㄪᰝࢆ⥅⥆ⓗ࡟⾜ࡗ࡚࠸ࡿࠋ⤖ྜᆺ࣡ࢡࢳࣥᑟධᚋࠊ᪂ࡋࡃၥ㢟࡜࡞ࡗ࡚࠸ࡿ
࣡ࢡࢳࣥ㠀ྵ᭷ᆺᰴ࡟ࡼࡿ⑓ཎᅉᏊࡢゎᯒࢆ⾜࠸ࠊ᪂ࡓ࡞ண㜵ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋࡲࡓࠊ㞴἞ᛶ࿧྾ჾឤᰁ⑕ࡢ
デ᩿ࠊ἞⒪ἲ㛤Ⓨࡢࡓࡵࡢ⮫ᗋ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡿࠋྠ᫬࡟ࠊ㝃ᒓ⑓㝔࡟࠾ࡅࡿデ⒪άືཬࡧᏛෆእ࡛ࡢࢥࣥࢧ
ࣝࢸ࣮ࢩࣙࣥࢆ⾜ࡗ࡚࠸ࡿࠋ
Our research focuses on sero-epidemiology and pathogenesis of Haemophilus influenzae, Streptococcus
pneumoniae and Streptococcus agalactiae. We organize several clinical researches for development of
diagnostic and therapeutic methods of intractable respiratory infectious diseases collaborating withclinicians and also care for the patients in Chiba University Hospital.
୺࡞ࢸ࣮࣐ (Research Focus)
1㸧࢖ࣥࣇ࢚ࣝࣥࢨ⳦ឤᰁ⑕ࡢ␿Ꮫཬࡧ⑓ཎᅉᏊゎᯒ2㸧⫵⅖⌫⳦ឤᰁ⑕ࡢ␿Ꮫཬࡧ⑓ཎᅉᏊゎᯒ
3㸧B ⩌ࣞࣥࢧ⌫⳦ឤᰁ⑕ࡢ␿Ꮫཬࡧ⑓ཎᅉᏊゎᯒ
4㸧౵くᛶ⣽⳦ឤᰁ⑕࠾ࡼࡧ㞴἞ᛶ࿧྾ჾឤᰁ⑕ࡢデ᩿
࣭἞⒪ἲࡢ㛤Ⓨ
5㸧ࣄࢺᆺ⤖᰾⳦࡜ BCG ࡢ㎿㏿㚷ูデ᩿ἲࡢ㛤Ⓨ

1㸧Investigation of the pathogenesis and epidemiology of Haemophilus influenzae infection
2㸧Investigation of the pathogenesis and epidemiology of Streptococcus pneumoniae infection
3㸧Investigation of the pathogenesis and epidemiology of Streptococcus agalactiae infection
4㸧Development of diagnostic and therapeutic methods for invasive diseases and intractable respiratory
infectious diseases
5㸧Development of rapid differential diagnosis for Mycobacterium tuberculosis and M. bovis BCG(Staff)◊✲ࢫࢱࢵࣇ ≉௵ຓᩍ ➉ෆ ඾Ꮚ     Research Assistant Professor  Noriko Takeuchiᢏ⾡⫋ဨ ኱ᴋ ⨾బᏊ  
Research Technician      Misako Ohkusu

Lab URL

http://www.pf.chiba-u.ac.jp/research/project/ishiwada.html

Lab URL

http://www.pf.chiba-u.ac.jp/research/project/ishiwada.html

11┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
RNA ឤᰁ἞⒪Ꮫศ㔝 (Division of RNA Therapy)ఀᗞ ⱥኵ㸦≉௵ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Hideo Iba (Professor)ᮾி㒔ฟ㌟ࠋᮾி኱Ꮫ⌮Ꮫ㒊⏕≀໬Ꮫ⛉༞ᴗࠊ⌮Ꮫ༤ኈࠋྠᏛ⛉ຓᡭࠋ⡿ᅜࣟࢵࢡࣇ࢙࣮ࣛ኱Ꮫ㸦ⰼᡣ⚽୕㑻ᩍᤵ㸧ฟᙇࠋᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤຓᩍᤵࠋྠ◊✲ᡤ࣭ឤᰁච␿㒊㛛࣭ᐟ୺ᐤ⏕యᏛศ㔝ᩍᤵࠋ ᖺࡼࡾ⌧⫋ࠋ ᖺ᪥ᮏ⒴Ꮫ఍ዡບ㈹ཷ㈹ࠋ

RNA ไᚚࣉࣟࢪ࢙ࢡࢺ
Project for RNA Regulation
ᴫせ (Abstract)⣽⬊ෆ࡛ࡳࡽࢀࡿ㑇ఏᏊⓎ⌧ࡢᵝᘧࡣࠊ┿⳦࣭⣽⳦࣭࢘࢖ࣝࢫ➼ࡢᐤ⏕య࡟ᑐࡍࡿᐟ୺ࡢᛂ⟅ᛶࡸ FRPSHWHQF\ࢆࡶつᐃࡋ࡚࠸ࡿࠋࡇࡢⓎ⌧ᵝᘧࡣࠊከࡃࡢᅉᏊ࡟ࡼࡾไᚚࡉࢀ࡚࠸ࡿࡀࠊ⚾࡝ࡶࡣࡑࡢ࡞࠿࡛ࡶ≉࡟ࠊ㸯㸧ྛ㑇ఏᏊࡢࣉ࣮ࣟࣔࢱ࣮ୖ࡛స⏝ࡍࡿ NF-kappaB, AP-1 ➼ࡢ㌿෗ไᚚᅉᏊ⩌ࠊ㸰㸧6:,61) 」ྜయ࡟௦⾲ࡉࢀࡿᰁⰍయࡢάᛶ໬≧ែࢆไᚚࡋ࡚࠸ࡿࢡ࣐ࣟࢳࣥᵓ㐀ኚ᥮ᅉᏊࠊ㸱㸧ከᩘࡢ㑇ఏᏊ⩌ࡢⓎ⌧ࢆ SRVWWUDQVFULSWLRQࡢ୍࡛ࣞ࣋ࣝᣓࡋ࡚㈇࡟ไᚚࡍࡿ miR-21, miR-200 ࡸ miR-199a࡜࠸ࡗࡓ PL51$ࠊࡢ㸱⪅࡟ὀ┠ࡋ࡚࠸ࡿࠋឤ
ᰁࠊ⅖⑕ࠊ⒴࡞࡝࡟క࠸ࠊࡇࢀࡽ  ⪅ࡀᙧᡂࡍࡿ㑇ఏᏊไᚚࢿࢵࢺ࣮࣡ࢡࡢゎ᫂ࢆ㐍ࡵ࡚ࠊ✀ࠎࡢࣄࢺ⑌ᝈࡢ἞⒪ᶆⓗࢆᢳฟࡋࠊࡑࡢ⑌ᝈࡢไᅽ࡟⤖ࡧࡘࡅࡿࡇ࡜ࢆ┠ᶆ࡜ࡋ࡚࠸ࡿࠋ
Gene expression patterns in a cell determine the cellular competency to mycete, bacterium, and virus.
Whereas these expression patterns are regulated by many factors, we have been concentrating on following
three factors; 1) transcriptional factors such as NF-kappaB and AP-1, which operate on the promoter regionof their target genes, 2) chromatin remodeling factors such as SWI/SNF complexes that modulate the stateof chromatin activity, 3) miRNAs including miR-21, miR-200 and miR-199a, which suppress many genes atthe post-transcriptional level. We will elucidate gene regulatory networks formed by these three factors in
the process of infection, inflammation and tumor formation to establish new therapeutic strategies forhuman diseases.
୺࡞ࢸ࣮࣐ (Research Focus)
1) NF-kappaBࡢ㌿෗άᛶ໬ࢆᢚไࡍࡿ≉␗ⓗ࡞㜼ᐖ๣ࡢ㛤Ⓨ2) ⚾ඹࡀ㛤Ⓨࡋࡓ≉␗ⓗ࡞miRNAࢆᙉຊ࡟㜼ᐖࡍࡿRNA decoy, TuD/S-TuD ࢆ౑⏝ࡋࡓRNA๰⸆ࡢ☜❧1) Development of specific inhibitors that suppress the transactivating activity of NF-kappaB
2) Establishment of RNA medicine using RNA decoys developed by us, TuD/S-TuD, which strongly inhibits
specific miRNA activity◊✲ࢫࢱࢵࣇ
≉௵ຓᩍ≉௵◊✲ဨ
≉௵◊✲ဨ
ᢏ⾡⿵బဨ
ᢏ⾡⿵బဨ

(Staff)ཎཱྀ ೺     Research Assistant Professor
Takeshi Haraguchiᑠᯘ ࿴ၿ   Research Fellow 
Kazuyoshi Kobayashiᖹᯇ ᐶ᫂   Research Fellow
Hiroaki Hiramatsuᱜ஭ ඾Ꮚ   Research Promotion Technician Noriko Sakurai┦ᕝ ᑦ⨾   Research Promotion Technician Naomi Aikawa

Lab URL  http://www.pf.chiba-u.ac.jp/research/scientists_list/iba.html
Lab URL
http://www.pf.chiba-u.ac.jp/research/scientists_list/iba.html
12┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources)㧗ᶫ ᘯ႐㸦෸ᩍᤵ࣭PI㸧
Hiroki Takahashi (Associate Professor)රᗜ┴⏕ࡲࢀࠋி㒔኱Ꮫ༞ᴗᚋࠊዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫ᝟ሗ⛉Ꮫ◊✲⛉ಟ஢ࠋዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫ᝟ሗ⛉Ꮫ◊✲⛉ຓᩍࢆ⤒࡚ 2012 ᖺᗘࡼࡾ⌧⫋ࠋᚤ⏕≀๰⏕ࣉࣟࢪ࢙ࢡࢺ
Project for Systems Biology of Microorganisms
ᴫせ (Abstract) ᡃࠎࡣࠊḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࢆྵࡴᵝࠎ࡞⏕≀ᐇ㦂࡛ᚓࡽࢀࡿ኱㔞ࢹ࣮ࢱࢆᑐ㇟࡟ࠊ᪂つゎᯒᡭἲࡢ㛤Ⓨࡸ㧗ᛶ⬟ࡢࢥࣥࣆ࣮ࣗࢱࢆ⏝࠸ࡓࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡲࡓࠊᩘ⌮ࣔࢹࣝ࢔ࣉ࣮ࣟࢳ࡟ࡼࡿ⏕࿨⌧㇟ࡢゎ᫂࡟ྲྀࡾ⤌ࢇ࡛࠸ࡲࡍࠋ኱㔞ࢹ࣮ࢱ࡟ࡼࡿ⏕࿨ࡢࠕᵓᡂせ⣲ࡢ⌮ゎࠖࠊᩘ⌮ࣔࢹࣝ࡟ࡼࡿࠕᣲືࡢ⌮ゎࠖ࡜࠸࠺஧ࡘࡢࢥࣥࢭࣉࢺࡢୗࠊ
⑓ཎ┿⳦ࢆྵࡴᚤ⏕≀ࢆᑐ㇟࡟⣽⬊ᶵ⬟ࡢศᏊ࡛ࣞ࣋ࣝࡢ⌮ゎࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋ
Our research areas are Bioinformatics and Systems
Biology. Our Bioinformatics approach aims to deeply andclearly understand massive biological experiment data, e.g.,
sequence data by next generation sequencers. Systems
Biology aims to understand how biological systems work and help the experimental design mainly bymathematical modelling approach.
୺࡞ࢸ࣮࣐ (Research Focus) 1) ⑓ཎ┿⳦ࡢ⎔ቃࢫࢺࣞࢫᛂ⟅⬟ࡢゎ᫂2) ⑓ཎ┿⳦ࢤࣀ࣒ࡢከᵝᛶゎᯒ3) ḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࢆ୰ᚰ࡜ࡋࡓ࣑࢜ࢵࢡࢫࢹ࣮ࢱࡢ᝟ሗᏛⓗゎᯒ4) ᩘ⌮ࣔࢹࣝ࢔ࣉ࣮ࣟࢳ࡟ࡼࡿ㔠ᒓᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂1) Understanding of environmental stress responses in pathogenic fungi2) Comparative genomics for pathogenic fungi3) NGS data analysis and software development
4) Mathematical modelling approach for the regulation system of essential metals◊✲ࢫࢱࢵࣇ
≉௵ຓᩍ  ᴋᒇ 㝧Ꮚ≉௵ຓᩍ  ▼ཎ ₶୍ᢏ⾡⿵బဨ Ᏺ  ᾴᏊᢏ⾡⿵బဨ ඵཎ ࠶ࡎࡉᢏ⾡⿵బဨ ㎶  ᙬ(Staff)Research Assistant Professor
Research Assistant Professor
Research Promotion Technician
Research Promotion Technician
Research Promotion Technician

Yoko Kusaya
Jun-ichi Ishihara
Ryoko Mori
Azusa Yahara
Cai Bian

Lab URL  http://bioinfo.pf.chiba-u.jp, https://www.facebook.com/chiba.takahashi.lab

Lab URL

13

http://bioinfo.pf.chiba-u.jp, https://www.facebook.com/chiba.takahashi.lab┿⳦⑕◊✲㒊㛛(Department of Mycosis Research)
ᚤ⏕≀㈨※ศ㔝 (Division of Bio-resources)▮ཱྀ ㈗ᚿ㸦෸ᩍᤵ࣭ᐊ㛗㸧
Takashi Yaguchi (Associate Professor)᪩✄⏣኱Ꮫ኱Ꮫ㝔⌮ᕤᏛ◊✲⛉༤ኈ๓ᮇㄢ⛬ಟ஢ᚋࠊ᫂἞〇Ⳬ㸦ᰴ㸧ධ♫ࠊ1995 ᖺ᪩✄⏣኱Ꮫࡼࡾ༤ኈྕ
ࢆཷ㡿ࠊ2003 ᖺ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮࣭ຓ
ᩍᤵ࡜ࡋ࡚ᑵ௵ࠊ⌧ᅾ࡟⮳ࡿࠋ୺࡞ཷ㈹Ṕ㸸᪥ᮏ⳦Ꮫ఍⳦Ꮫ◊✲ዡບ㈹㸦1996 ᖺ㸧ࠊ᪥ᮏ་┿⳦Ꮫ఍◊✲ዡ
ບ㈹㸦2009 ᖺ㸧ࠊ᪥ᮏ⳦Ꮫ఍㈹㸦2016 ᖺ㸧ࣂ࢖࢜ࣜࢯ࣮ࢫ⟶⌮ᐊ
Management Unit of Microbiological Resourcesᴫせ (Abstract)⑓ཎ┿⳦࣭ᨺ⥺⳦ࡢࠕಖᏑ࣭⟶⌮࣭ᥦ౪ࠖయไࢆᩚഛࡋࠊ᭱᪂᝟ሗࡀ௜ຍࡉࢀࡓಙ㢗࡛ࡁࡿ⳦ᰴࡢᥦ౪ࢆ㏻ࡌ࡚ࠊ┿⳦⑕࡞ࡽࡧ࡟ࡑࡢཎᅉ⳦ࡢ◊✲࣭ᩍ⫱ࡢᇶ┙ࢆᨭ᥼ࡋ࡚࠸ࡿࠋ
We are developing a system for preservation, management and distribution of pathogenic fungi andactinomycetes. We support the base of research and education of mycoses and their pathogens in order tosupply reliable strains that are added new information.
୺࡞ࢸ࣮࣐ (Research Focus)⳦ᰴ⟶⌮ࡢ୍⎔࡜ࡋ࡚ࠊ⑓ཎ┿⳦ࡢᙧែ࠾ࡼࡧ⣔⤫ゎᯒࠊ✀ෆከᆺ࠾ࡼࡧᇵ㣴⣔୪ࡧ࡟㠀ᇵ㣴⣔࡟࠾ࡅࡿ㎿㏿ྠᐃࡢ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡿࠋࡲࡓࠊࢤࣀ࣒ゎᯒࠊ஧ḟ௦ㅰ⏘≀ࡢ᥈⣴࡞࡝ࢆ⾜࠸ࠊ⳦ᰴ㈨※࡜ࡋ࡚ࡢ௜ຍ౯್ࡢྥୖ࡟ດࡵ࡚࠸ࡿࠋ୺せ࡞ࢸ࣮࣐ࡣ௨
ୗࡢ࡜࠾ࡾ࡛࠶ࡿࠋ
1) ⑓ཎᛶ Aspergillus ࠾ࡼࡧ㛵㐃⳦࡟࠾ࡅࡿᙧែ࠾ࡼࡧ⣔⤫ゎᯒ࡟ࡼࡿศ㢮Ꮫⓗ◊✲2) ⑓ཎᛶ Candida ᒓࡢศᏊ␿Ꮫⓗᡭἲ࡟ࡼࡿศ㢮Ꮫⓗ◊✲
We are studying on morphological and phylogenetical analysis and intra-species
polymorphism of fungal pathogens, and rapid identification in the culture or
non-culture system. We are also analyzing whole genome and secondary
metabolites to enhance additional value as bio-resource. The main themes arefollowing as:1) Studies on the classification of pathogenic Aspergillus spp. and related species
based on phenotypic and molecular characteristics.
2) Reexamination and genotyping of pathogenic Candida spp.
◊✲ࢫࢱࢵࣇ
ຓᩍ
ᢏ⾡⫋ဨ
ᢏ⾡⿵బဨ
ᢏ⾡⿵బဨ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ
㠀ᖖ໅ㅮᖌ

⏣୰ ⋹Ꮚఀ⸨ ⣧Ꮚ㛗ᮧ ⏤⨾ᒣ୰ ⨾ⰼ
ᇼỤ ⩏୍㧗ᶫ ᐜᏊ
ΎỈ ⏤ᕭ✄⚟ ࿴ᏹ

(Staff)Assistant Professor
Research Technician:Research Promotion Technician
Research Promotion Technician
Visiting Lecture
Visiting Lecture
Visiting Lecture
Visiting Lecture

Reiko Tanaka
Junko Ito
Yumi Osamura
Mika Yamanaka
Yoshikazu Horie
Yoko Takahashi
Yumi Shimizu
Kazuhiro Inafuku

⳦ᰴಖᏑLab URL  http://www.pf.chiba-u.ac.jp/bunya_biseibutsushigen.html

Lab URL

http://www.pf.chiba-u.ac.jp/bunya_biseibutsushigen.html
14┿⳦⑕ᑓ㛛እ᮶ (Specialty Clinic for Invasive Fungal Diseases)ட஭ඞᙪ㸦ᩍᤵ࣭ศ㔝㛗࣭PI㸧
Katsuhiko Kamei (Professor)⊦⊁ⱥಇ㸦㝃ᒓ⑓㝔デ⒪ᩍᤵ࣭ឤᰁ⑕ෆ⛉⛉㛗㸧
Hidetoshi Igari (Associate Professor)
Ώ㎶ဴ㸦෸ᩍᤵ㸧
Akira Watanabe (Associate Professor)ᴫせ (Abstract)ᙜࢭࣥࢱ࣮࡛ࡣ 2014 ᖺ 10 ᭶ࡼࡾឤᰁ⑕ෆ⛉ࡢ༠ຊࡢୗࠊ་Ꮫ㒊㝃ᒓ⑓㝔࡟࠾࠸࡚᪥ᮏึ࡜࡞ࡿ῝ᅾᛶ┿⳦⑕ࡢᑓ㛛እ᮶ࢆ㛤タࡋእ᮶デ⒪ཬࡧධ㝔἞⒪ࢆ⾜ࡗ࡚࠸ࡿࠋ㉸㧗㱋♫఍ࢆ㏄࠼ࡓᡃࡀᅜ࡛ࡣࠊCOPD ࡞࡝ࡢ៏ᛶ⑌
ᝈࢆࡶࡘᝈ⪅࡛ࡢ῝ᅾᛶ┿⳦⑕Ⓨ⑕ᩘࡀቑຍࡋ࡚࠸ࡿࠋࡉࡽ࡟་⒪ࡢ㧗ᗘ໬࡟క࠸デ⒪⛉ࢆၥࢃࡎ῝ᅾᛶ┿⳦⑕ࡀၥ㢟࡜࡞ࡗ࡚࠸ࡿࠋ᭦࡟㏆ᖺࡣᢠ┿⳦⸆࡟⪏ᛶࢆ᭷ࡍࡿ┿⳦ࡢឤᰁ౛ࡀቑຍࡋ࡚࠾ࡾࠊ௒ᚋࡲࡍࡲࡍ㞴἞໬ࡋ࡚ࡺࡃࡇ࡜ࡀண᝿ࡉࢀࡿࠋࡇࡢᑓ㛛እ᮶࡛ࡣࠊᙜࢭࣥࢱ࣮ࡢࡶࡘ᭱᪂㗦ࡢ᳨ᰝデ᩿ᶵჾࡣࡶࡕࢁࢇࡢ஦ࠊᇶ♏◊✲ࡢᡂᯝࢆ᭱኱㝈࡟ά⏝ࡋࠊ୍⯡デ⒪ࡢᯟࢆ㉸࠼ࡓ᭱㧗ࣞ࣋ࣝࡢデ⒪ࢆ⾜ࡗ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞⮫ᗋ࡜ᇶ♏◊✲࡜ࡢᐦ࡞ࢥ࣮ࣛ࣎ࣞࢩࣙࣥࡣᙜࢭࣥࢱ࣮ࡢࡳࡀᡂࡋ࠼ࡿ኱ࡁ࡞≉Ⰽ࡛࠶ࡾࠊᡃࡀᅜ࡟࠾ࡅࡿ῝ᅾᛶ┿⳦⑕ࡢᣐⅬ࡜ࡋ࡚ࠊ㞴἞ឤᰁ⑕࡛࠶ࡿ῝ᅾᛶ┿⳦⑕ࡢデ᩿ࠊ἞⒪ࡢ୍ᒙࡢྥୖࢆ┠ᣦࡋ࡚άືࢆ⥆ࡅ࡚࠸ࡿࠋOn Oct. 2014, we opened the Japan’s first specialty clinic for invasive
fungal diseases (IFD) in Chiba University Hospital. In step with the aging of
the population, number of the IFD patients with chronic lung diseases suchas COPD are increasing. Moreover, highly advanced medical treatment also
results in an upward trend of number of the IFD patients. IFD arerefractory and have a high mortality. Furthermore, antifungal-resistantclinical strains of fungi are increasing. Given the situation, intractable IFD
should become a serious problem in near future. In the specialty clinic, we
provide medical care of the highest level to our patients collaboratingwith MMRC (bedside to benchside), aiming at the further advanced medical
treatment for IFD.

⫵࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࡢ CT ീ୺࡞ࢸ࣮࣐ (Research Focus)1) ῝ᅾᛶ┿⳦⑕ᝈ⪅ࡢእ᮶デ⒪࠾ࡼࡧධ㝔἞⒪2) ௚⛉ཬࡧእ㒊་⒪ᶵ㛵࡟ᑐࡍࡿ῝ᅾᛶ┿⳦⑕ᝈ⪅ࡢデ⒪ᨭ᥼ࠊࢭ࢝ࣥࢻ࢜ࣆࢽ࢜ࣥ࡞࡝3) ⮫ᗋศ㞳ᰴࡢゎᯒ㸦⑓ཎᅉᏊࡢ᥈⣴ࠊ⸆๣⪏ᛶࡢࣉࣟࣇ࢕࣮ࣝ࡜ࡑࡢᶵᵓゎ᫂㸧┿⳦⑕ᑓ㛛እ᮶࡛ࡢデᐹ㢼ᬒ1) Medical examination and treatment for IFD for outpatients and inpatients
2) Consultation and assistance of medical care for IFD patients, second opinion
3) Analyses of clinical fungal strains (virulence factor, mechanism of resistance)ᑓ㛛እ᮶ཷ௜
┿⳦⑕ᑓ㛛እ᮶ࡣឤᰁ⑕ෆ⛉ࡢ୍⩼ࢆᢸࡗ࡚࠸ࡿ

15┿⳦ࡢ⳦✀ྠᐃࡢ㘽࡜࡞ࡿࢩ࣮ࢡ࢚ࣥࢧ࣮

ࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ(NBRP)
⑓ཎ┿᰾ᚤ⏕≀ (Pathogenic microbes)ᩥ㒊⛉Ꮫ┬࡛ࡣ 2002 ᖺᗘ࠿ࡽࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ㸦NBRP㸧ࢆ㛤ጞࡋࠊᅜࡀᡓ␎ⓗ࡟ᩚഛࡍࡿࡇ࡜ࡀ㔜せ࡞⏕≀㈨※࡟ࡘ࠸࡚య⣔ⓗ࡟཰㞟ࠊಖᏑࠊᥦ౪࡞࡝ࢆ⾜࠺ࡓࡵࡢయไࢆᩚഛࡋ࡚ࡁࡓࠋࡑࡢᚋ
5 ᖺࡈ࡜ࡢぢ┤ࡋࢆ⾜࠸ࠊ2017 ᖺᗘࡼࡾ➨ 4 ᮇࡀ㛤ጞࡉࢀࡓࠋ
➨ 4 ᮇࡼࡾ⑓ཎ⣽⳦࡜⑓ཎ┿⳦࣭ཎ⹸ࡣูࠎ࡟άືࡍࡿࡇ࡜࡜࡞ࡾࠊNBRP ⑓ཎ┿᰾ᚤ⏕≀࡟ࡣ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㸦⑓ཎ┿⳦࣭ᨺ⥺⳦ࠊ୰᰾ᶵ㛵㸧࡜㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤ㸦⑓ཎᛶཎ⹸㸧ࡣࠊ┦஫ࡢᶵ㛵ࡢ㐃ᦠࢆᅗࡾࠊࡇࢀࡽࡢ⑓ཎᚤ⏕≀ᰴࡢ཰㞟࣭ಖᏑ࣭ᥦ౪యไࢆᩚഛࡋ࡚ࠊ㧗ᗘ᝟ሗࢆ㈿୚ࡋࡓಙ㢗࡛ࡁࡿ⑓ཎᚤ
⏕≀ᰴ࡜ࡋ࡚ᥦ౪ࡋࠊឤᰁ⑕࡜⑓ཎయࡢᩍ⫱࣭◊✲ࢆࡍࡿேࠎࢆᨭ᥼ࡋ࡚࠸ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ௒ᚋ࠸࠿࡞ࡿឤᰁ⑕ࡀⓎ⏕ࡋ࡚ࡶᑐᛂ࡛ࡁࡿ⑓ཎ┿᰾ᚤ⏕≀ࢥࣞࢡࢩࣙࣥࢆ┠ᣦࡋ࡚࠸ࡿࠋIn FY2002, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) implemented the
National BioResource Project (NBRP) to construct the framework for systematic collection, preservation,and distribution of bioresources, with a focus on those that required strategic development by the national
government. After the reviewing the NBRP every five years, in FY2017, the forth phase has started.
This project is carried out by Chiba University’s Medical Mycology Research Center (pathogenic
fungi/actinomycetes), and Nagasaki University’s Institute of Tropical Medicine (pathogenic protozoa).
Together, they cooperate in various efforts to support education and research pertaining to infectious
diseases and pathogens. Specifically, they are developing a system for collection, preservation, anddistribution of pathogenic microorganisms, and they supply reliable strains of pathogenic microorganismsthat are backed by high-level information.
Even if any infection develops, the project aims at the pathogenic microorganism collection to deal with it.
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H24 ᖺᗘ
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┿⳦
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153 (1,981) 106 (1,584) 106 (1,375) 108 (1,330)ᨺ⥺⳦
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14 (40)㧗ᗘ⑓ཎ┿⳦࡟☜ᐇ࡟ᑐᛂ࡛ࡁࡿ P3 ᪋タࠕ⑓ཎᚤ⏕≀ࠖయไᅗ



Lab URL  http://pathogenic.lab.nig.ac.jp/

Lab URL

http://pathogenic.lab.nig.ac.jp/
16




ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ    ඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬࡣࠊᩥ㒊⛉Ꮫ┬ࡀᖹᡂ  ᖺᗘ࡟๰タࡋࡓไᗘ࡛࠶
ࡾࠊᏛ⾡◊✲ࡢᇶ┙ᙉ໬࡜᪂ࡓ࡞Ꮫ⾡◊✲ࡢᒎ㛤ࢆ┠ᣦࡋࠊಶࠎࡢ኱Ꮫࡢᯟ
ࢆ㉺࠼ࠊ◊✲タഛࡸ㈨ᩱ࣭ࢹ࣮ࢱ࡞࡝
ࢆ඲ᅜࡢ◊✲⪅ࡀά⏝ࡋ࡚ඹྠ࡛◊✲ࢆᐇ᪋ࡍࡿయไࢆᩚഛࡍࡿࡓࡵࡢࡶࡢ
࡛ࡍࠋ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ࡣࠊᖹᡂ ᖺ࡟ᩥ㒊⛉Ꮫ኱⮧࠿ࡽඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬࠗ┿⳦ឤᰁ⑕◊✲ᣐⅬ࠘࡟ㄆᐃࡉࢀࠊᖹᡂ  ᖺᗘ࡟ࡣࠊ➨㸰ᮇ୰ᮇ┠ᶆᮇ㛫࡟࠾ࡅࡿᮇᮎホ౯ࡢ⤖ᯝ࡟
ᇶ࡙ࡁᣐⅬࡀ෌ᗘㄆᐃࡉࢀࠊᖹᡂ  ᖺᗘ࠿ࡽࡢᣐⅬάືࡀ㛤ጞࡉ࡚࠸ࡲࡍࠋ ᮏࢭࣥࢱ࣮ࡢࠗ┿⳦ឤᰁ⑕◊✲ᣐⅬ࡛࠘ࡣࠊ┿⳦࣭ᨺ⥺⳦࡟ࡼࡿឤᰁ⑕◊✲࡜ࡑࡢᡂᯝ࡟ࡼࡿ♫఍㈉⊩ࢆ┠ⓗ࡟ࠊ┿⳦࣭ᨺ⥺⳦ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࢆඹ
ྠ฼⏝ࡢᇶ┙࡜ࡋ࡚ᩚഛ࣭ά⏝ࡋࠊ⑓ཎ┿⳦࣭ᨺ⥺⳦ࡢᇶ♏◊✲࠾ࡼࡧࡑࢀࡽ࡟ࡼࡿឤᰁ⑕ࡢデ᩿ࠊ἞⒪ࠊண㜵ἲ࡟㛵ࡍࡿ◊✲࡟࠾࠸࡚ࠊᅜෆእࡢᩍ⫱◊✲᪋タ࡜ࡢඹྠ◊✲ࢆ⾜࠸ࠊ㛵㐃ศ㔝ࡢேᮦࢆ⫱ᡂࡍࡿࡇ࡜ࢆ┠ᶆ࡜ࡋ࡚άືࡋ࡚࠸ࡲࡍࠋࡲࡓ᭱㏆ࡣࠊ⣽⳦ࡸ࢘࢖ࣝࢫ࡞࡝ࡢ௚ࡢ⑓ཎయࢆྵࡵࡓឤᰁ⑕◊✲ࠊᐟ୺ච␿ᛂ⟅ࡸࢩࢢࢼࣝఏ㐩ไᚚ◊✲ࠊࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ࡞࡝ࡢ㛵㐃ࡍࡿ◊✲㡿ᇦ࡟ࡶᑐ㇟ࢆᗈࡆࡓඹྠ฼⏝࣭ඹྠ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡲࡍࠋᣐⅬ࡜ࡋ࡚ࡢ┠ⓗࢆ㐩ᡂࡍࡿࡓࡵ࡟ࠊᩥ㒊⛉Ꮫ┬࠾ࡼࡧ༓ⴥ኱Ꮫ࠿ࡽࡢᨭ᥼ࢆཷࡅࠊᗈࡃඹྠ
฼⏝࣭ඹྠ◊✲࡟ᑐࡋ࡚◊✲㈝ࢆ㓄ศࡍࡿ࡜࡜ࡶ࡟ࠊᖺ࡟㸯ᅇឤᰁ⑕◊✲ࢢ࣮ࣟࣂࣝࢿࢵࢺ࣮࣡ࢡࣇ࢛࣮࣒ࣛࡢ
㛤ദࢆᨭ᥼ࡍࡿࡇ࡜࡛ࠊࡼࡾᏛ㝿ⓗ࡞◊✲ࢿࢵࢺ࣮࣡ࢡᙧᡂࡋࠊ㛵㐃ࡍࡿ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕ࡢ◊✲ᇶ┙ࡢᙉ໬࡜◊✲᥎㐍࡟㈉⊩ࡋ࡚࠸ࡲࡍࠋ               !" # "$"# %& # % '$   &  *!+'9  : ' <           = 9 >< 

$$  ?     "&  " :9!?"  $ 

$"

@ " "  < :G9K?$&<"<  " <<"<$  :
$#  "&& $$         $ # $"   $  ? $   #   <<"$ $    <  : Q"#  $  "&&    $ <  &<     V     V$ $ : ඹྠ฼⏝࣭ඹྠ◊✲ࡢㄢ㢟࠾ࡼࡧ◊✲఍ࡣࠊẖᖺ  ᭶࡟඲ᅜ࡟බເࡋࠊ㛵㐃ࢥ࣑ࣗࢽࢸ࢕࡟ᒓࡍࡿእ㒊ࡢᑓ㛛ᐙࢆጤဨ࡜ࡍࡿ㐠Ⴀ༠㆟఍࡟࠾࠸࡚༠㆟ࡋࡓ࠺࠼࡛ࠊ᥇ᢥࡋ࡚࠸ࡲࡍࠋྛᖺᗘࡢබເࡢෆᐜࠊ᥇ᢥㄢ㢟ࠊ◊✲ᡂᯝ࡞࡝࡟ࡘ࠸࡚ࡣࠊᮏࢭࣥࢱ࣮ࡢ࣮࣒࣮࣍࣌ࢪ࡟බ㛤ࡋ࡚࠸ࡲࡍࠋ⯆࿡ࡢ࠶ࡿ᪉ࡣࠊබເせ㡿ࢆࡈ☜ㄆࡋ࡚࠸ࡓࡔࡁࠊᮏࢭࣥࢱ࣮ࡢᩍဨ࡜ࡈ┦ㄯࡢ࠺࠼ᛂເࡋ࡚࠸ࡓࡔࡃࡼ࠺࠾㢪࠸࠸ࡓࡋࡲࡍࠋ

17ᖹᡂᖺᗘඹྠ฼⏝࣭ඹྠ◊✲ཷධㄢ㢟    !"#$
θ

௦ࠉ⾲ࠉ⪅

◊ࠉ✲ࠉㄢࠉ㢟㑇ఏᏊࢧ࢖ࣞࣥࢩࣥࢢ࡜⮬↛ච␿཯ᛂࡢࢡࣟࢫࢺ࣮ࢡᶵᵓࡢゎᯒᮾி኱Ꮫ኱Ꮫ㝔⌮Ꮫ⣔◊✲⛉

෸ᩍᤵ

⛬ࠉஂ⨾Ꮚ

Molecular interaction between gene silencing and innate immune response

Graduate School of Science, The University of Tokyo

Associate Prof.

Kumiko Ui-Tei'HFWLQࢩࢢࢼࣝఏ㐩⣔ࢆᶆⓗ࡟ࡋࡓ᪂つ㞴἞ᛶ⑊③ไᚚἲࡢ㛤Ⓨ㮵ඣᓥ኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉

෸ᩍᤵ

ᰩཎࠉᓫ

Development of a new treating strategy for intractable pain by controlling dectin-1 signaling pathway

Graduate School of Medical and Dental Sciences,
Kagoshima University

Associate Prof.

Takashi Kuriharaឤᰁ࡟ᛂ⟅ࡋࡓ⮬↛ච␿ㄏᑟࡢศᏊᶵᵓࡢゎᯒி㒔኱Ꮫ࢘࢖ࣝࢫ◊✲ᡤ

ᩍᤵ

⸨⏣ࠉᑦᚿ

Innate immune responses against pathogen infection

Institute for Virus Research, Kyoto University

Professor

Takashi Fujita,/࡟ࡼࡾไᚚࡉࢀࡿዲ୰⌫౫Ꮡᛶ&DQGLGDDOELFDQV ឤᰁ㜵ᚚᶵᵓࡢゎ᫂༓ⴥ኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲㝔

་ဨ

ⱝᯘṇ୍㑻

Analysis of neutrophil-dependent protective mechanisms of Candida albicans regulated by IL-17

Graduate School of Medicine, Chiba University

Medical Staff

Seiichiro Wakabayashi

෸ᩍᤵ

Ἑྜࠉኴ㑻

Associate Prof.

Taro Kawai

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㸰㸬

㸱㸬

㸲㸬
┿⳦ᡂศㄆ㆑࡟㛵ࢃࡿ᪂ࡓ࡞⮬↛ච␿ཷᐜయࡢゎᯒ㸳㸬Studies on innate immune responses to the fungal cell wall componentዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫࣂ࢖࢜ࢧ࢖࢚ࣥࢫ◊✲⛉Graduate School of Biological Sciences, Nara Institute of
Science and Technologyࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ┿⳦⑓ཎᛶⓎ⌧ᶵᵓ࡜ᐟ୺⮬↛ච␿ᛂ⟅ࡢゎᯒᮾ໭኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲⛉ᩍᤵ಴⏣ࠉ⚈୍ᮁ

Analysis of fungal virulence mechanism and host innate immune responses using Drosophila

Graduate School of Pharmaceutical Sciences,Tohoku
University

Professor

Shoichiro Kurata&DQGLGDJODEUDWD ⣽⬊ቨᵓ⠏㛵㐃㑇ఏᏊḞᦆࡀ⳦యࡢᛶ㉁࡟ཬࡰࡍᙳ㡪ᮾ໭་⛉⸆⛉኱Ꮫ

ᩍᤵ

ᰘ⏣ࠉಙஅ

Analysis of the mutant set involving the cell wall integrity of Candida glabrataTohoku Medical and Pharmaceutical University

Professor

Nobuyuki Shibata

Senior Research
Fellow

Erwin Lamping

Assistant Prof.

Miguel C Teixeira㸴㸬㸵㸬⸆๣ᶆⓗ㛤Ⓨࢆ┠ᣦࡋࡓࣃࣥ㓝ẕ࡜࢝ࣥࢪࢲ࣭ࢢࣛࣈ࣮ࣛࢱࡢ⏕⫱ᚲ㡲㑇ఏᏊከᵝᛶゎᯒ㸶㸬㸷㸬Sir John Walsh Research Institute, University of Otago,
Aiming drug targets development, analysis of gene diversity for growth essential between the baker's yeast New Zealandand the Candida glabrata
Antifungal drug resistance in Candida glabrata from transcriptional control to drug extrusion:aiming
improved diagnosis and therapeutics

Institute for Bioengineering and Biosciences, Instituto
Superior Técnico/Bioengineering Department༓ⴥ኱Ꮫࡀಖ᭷ࡍࡿ࢜ࣜࢪࢼࣝ໬ྜ≀ࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸ࡓᢠ┿⳦⸆ࢩ࣮ࢬࡢ㛤Ⓨ༓ⴥ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉

ᩍᤵ

Ⲩ஭ࠉᏕ⩏

Development of the antifungal seeds from the original compound library in Chiba University

Graduate School of Science,Chiba University

Professor

Takayoshi Arai

ᩍᤵ

㧗ᮌ༤ྐ

Professor

Hiroshi Takagi㸯㸮㸬ዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫࣂ࢖࢜ࢧ࢖࢚ࣥࢫ◊✲⛉Graduate School of Biological Sciences, Nara Institute ofAnalysis of synthetic regulatory mechanism and physiological function of nitric oxide in pathogenic fungus
Science and Technology⑓ཎ┿⳦࡟࠾ࡅࡿ୍㓟໬❅⣲ࡢྜᡂไᚚᶵᵓ࡜⏕⌮ᶵ⬟ࡢゎ᫂
㸯㸯㸬

㸯㸰㸬

$VSHUJLOOXVIXPLJDWXV ࡢ⑓ཎᛶ࡟࠾ࡅࡿ࢞ࣛࢡࢺࣇࣛࣀ࣮ࢫ⢾㙐ࡢᶵ⬟ゎᯒᓫᇛ኱Ꮫᛂ⏝ᚤ⏕≀ᕤᏛ⛉

෸ᩍᤵ

ᒸࠉᣅ஧

Functional analysis of galactofuranose-containing oligosaccharides in the pathogenicity of Aspergillus
fumigatus

Department of Applied Microbial Technology, Sojo
University

Associate Prof.

Takuji Oka࢔ࢫ࣌ࣝࢠࣝࢫ⑕ཎᅉ⳦ࡀ⏘⏕ࡍࡿ⎔≧࣌ࣉࢳࢻࡢᐟ୺ච␿ᛂ⟅཯ᛂ࡬ࡢᙳ㡪⏘ᴗᢏ⾡⥲ྜ◊✲ᡤ

୺௵◊✲ဨ

ᱵᮧࠉ⯙Ꮚ

Effect of cyclic peptides produced by pathogenic Aspergillus species on host immune response

National Institute of Advanced Industrial Science andTechnology

Principal InvestigatorMaiko Umemura࢔ࢫ࣌ࣝࢠࣝࢫࡢࣂ࢖࢜ࣇ࢕࣒ࣝᙧᡂ࠾ࡼࡧᢠ┿⳦⸆⪏ᛶ࡟㛵㐃ࡍࡿ᪂つ㑇ఏᏊ⩌ࡢ᥈⣴ᅜ❧ឤᰁ⑕◊✲ᡤ

㸯㸱㸬

୺௵◊✲ᐁ

ᱵᒣࠉ㝯

Screening of novel genes involved in biofilm formation and antifungal resistance in Aspergillus fumigatus National Institute of Infectious Diseases

Senior scientist

Takashi Umeyama

㸯㸲㸬

㸯㸳㸬

㸯㸴㸬

Aspergillus fumigatus ࣜ࣎ࢯ࣮࣒ᶆⓗ⸆๣⪏ᛶᰴ࡟࠾ࡅࡿ஧ḟ௦ㅰάᛶ໬ᶵᵓࡢゎ᫂ᮾி኱Ꮫ኱Ꮫ㝔⥲ྜᩥ໬◊✲⛉

෸ᩍᤵ

ὸ஭ࠉ⚞࿃

Activation of secondary metabolism in Aspergillus fumigatus strains with resistance to ribosometargeting chemicals

Graduate School of Arts and Sciences,The University of
Tokyo

Associate Prof.

Teigo Asai

⮫ᗋศ㞳$VSHUJLOOXVIODYXV ࡢ᪂つ஧ḟ௦ㅰ⏘≀⏕ྜᡂࢡࣛࢫࢱ࣮ᵓᡂ㑇ఏᏊࡢⓎ⌧ゎᯒᖏᗈ␆⏘኱Ꮫື≀࣭㣗ရ᳨ᰝデ᩿ࢭࣥࢱ࣮

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Transcriptome analysis of a novel secondary metabolite biosynthesis cluster in a clinical isolate ofAspergillus flavus

Obihiro University of Agriculture and Veterinary Medicine

Senior AssistantProfessor

Takahito Toyotome᪂⯆ᙉẘᛶ┿⳦&U\SWRFRFFXVJDWWLL ࡢ㧗⑓ཎᛶᶵᗎࡢච␿Ꮫⓗゎᯒᮾ໭኱Ꮫ኱Ꮫ㝔་Ꮫ⣔◊✲⛉

ᩍᤵ

ᕝୖࠉ࿴⩏

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Immunological analysis of a mechanism for high pathogenicity of Cryptococcus gattii

Graduate School of Medicine,Tohoku University

Professor

Kazuyoshi Kawakami$VSHUJLOOXV ࿧྾ჾ᳨య⮫ᗋศ㞳ᰴࡢ⳦✀ྠᐃ࣭⸆๣ឤཷᛶࡢ᳨ウᅜ❧⑓㝔ᶵᵓᮾி⑓㝔࿧྾ჾࢭࣥࢱ࣮

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Study of species identification and drug susceptibility䚷of Aspergillus 䚷 clinical isolates in respiratory
specimen

Center for Pulmonary Diseases,National Hospital
Organization Tokyo National Hospital

Medical Staff Chief Junko Suzuki㉁㔞ศᯒィࢆ⏝࠸ࡓ࢖ࣥࣇ࢚ࣝࣥࢨ⳦Ⳓ⭷ᆺู࡟㛵ࡍࡿ◊✲༓ⴥ኱Ꮫ་Ꮫ㒊㝃ᒓ⑓㝔

≉௵෸ᩍᤵ

బ⸨ࠉᏲ

Identification of Haemophilus influenzae capsular serotyping by use of matrix-associated laser desorption
Chiba University Hospitalisonization-time of flight mass spectrometry

Associate Prof.

Mamoru Satoh౵くᛶឤᰁ⑕⏤᮶࢖ࣥࣇ࢚ࣝࣥࢨ⳦ࡢ⑓ཎᅉᏊ࡟㛵ࡍࡿ◊✲㮵ඣᓥ኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉

ᩍᤵ

すࠉ㡰୍㑻

Pathogenesis of Haemophilus influenzae isolated from patients with invasive disease

Kagoshima University Graduate School of Medical and
Dental Sciences

Professor

Junichiro Nishi᪂つᢠ┿⳦๣ࡢྜᡂ࠾ࡼࡧάᛶホ౯◊✲ᮾி⌮⛉኱Ꮫ⌮Ꮫ㒊➨୍㒊ᛂ⏝໬Ꮫ⛉

ᩍᤵ

᳝ྡࠉຬ

Enantioselective synthesis of new antibacterial and antifungal agents and evaluation of its activity

Department of Applied Chemistry, Faculty of Science,
Tokyo University of Science

Professor

Isamu Shiina

KEMRI, Center for Microbiology Research

Principal Research
officer-Head

Christine Bii᫛࿴⸆⛉኱Ꮫ

ᩍᤵஂಖ⏣ࠉ㧗᫂

Professor

Takaaki Kubota

㸰㸮㸬

㸰㸯㸬

㸰㸰㸬 Molecular biological analysis of Cryptococcus and Candida species from selected Counties in Kenyaᮍ฼⏝ᚤ⏕≀ࢆ⣲ᮦ࡜ࡋࡓ῝ᅾᛶ┿⳦⑕἞⒪⸆ࢩ࣮ࢻ໬ྜ≀ࡢ᥈⣴㸰㸱㸬The search for seed compounds of antifungal drugs for deep-seated mycosis from unutilized microorganismShowa Pharmaceutical Universityࣄࢺ⑓ཎᛶ┿⳦࡟ᑐࡍࡿ᳜≀⑓ཎ⳦࣐࢖ࢥ࢘࢖ࣝࢫࢱࣥࣃࢡ㉁ࡢ⏕⫱㜼ᐖຠᯝࡢゎᯒ࡜ࡑࡢᮾி㎰ᕤ኱Ꮫ኱Ꮫ㝔㎰Ꮫ◊✲㝔་⒪⣲ᮦ࡜ࡋ࡚ࡢ㛤Ⓨ㸰㸬
Evaluation of anti-fungal proteins of mycoviruses infecting in plant pathogenic fungi and development of Graduate School of Agriculture, Tokyo University ofAgriculture and Technology
effective proteins derived from the mycoviruses.
&U\SWRFRFFXVQHRIRUPDQV ࡢឤᰁࢧ࢖ࢡࣝ࡟࠾ࡅࡿࢤࣀ࣒෌⦅ᡂࡢศᏊᶵᵓ࡜ࡑࢀࢆᶆⓗ࡜ࡋ༓ⴥ኱Ꮫ኱Ꮫ㝔⼥ྜ⛉Ꮫ◊✲⛉ࡓ᪂つ἞⒪ᡓ␎ࡢ㛤Ⓨ࡟ྥࡅ࡚㸰㸳㸬
Graduate School of Advanced Integration Science, Chiba
Towards development of novel therapeutic strategies targeting the mechanism of specific genome
University
rearrangement during infection cycle of Cryptococcus neoformans⮫ᗋ᳨య࠿ࡽศ㞳ࡉࢀࡓࢸࣝࣅࢼࣇ࢕ࣥపឤཷᛶ ⪏ᛶ ⓑⓄ⳦ᰴ࡟࠾ࡅࡿ⪏ᛶ໬࣓࢝ࢽࢬ࣒
ᖇி኱Ꮫ་┿⳦◊✲ࢭࣥࢱ࣮ࡢゎ᫂࡟ྥࡅࡓ㑇ఏᏊᕤᏛⓗ࢔ࣉ࣮ࣟࢳࡢᑟධ
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Terbinafine resistance of Trichophyton clinical isolates caused by specific point mutations in the squalene
Teikyo University Institute of Medical Mycology
epoxidase gene

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᳃ᒣ⿱඘

Associate Prof.

Hiromitsu Moriyama

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ᯇᾆᙲ

Professor

Akira Matsuura

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ᒣ⏣ࠉࠉ๛

Associate Prof.

Tsuyoshi Yamada⸆๣⪏ᛶ࠾ࡼࡧឤཷᛶ$VSHUJLOOXVIXPLJDWXV ᰴࡢ௦ㅰ⏘≀ࡢ࣓ࢱ࣮࣒࣎ࣟゎᯒ

ᫍ⸆⛉኱Ꮫ

ᩍᤵ

⣽Ụࠉᬛኵ

Metabolomics between drug-resistance and drug-sensitive Aspergillus fumigatus

Hoshi University

Professor

Tomoo Hosoe

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ᩍᤵ

ᕝୖࠉ࿴㆟

Immunological mechanism for high virulence of Cryptococcus gattii , an emerging infectious fungus

Graduate School of Medicine,Tohoku University

Professor

Kazuyoshi Kawakami಴⏣ࠉ⚈୍ᮁ

㸯㸬┿⳦⑓ཎᛶⓎ⌧ᶵᵓ࡜ᐟ୺⮬↛ච␿ᛂ⟅ࡢゎᯒᮾ໭኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲⛉ᩍᤵ

Study of fungal pathogenicity and host innate immune responses

Graduate School of Pharmaceutical Sciences Tohoku
University

Professor

Shoichiro Kurataឤᰁ࡟ᛂ⟅ࡋࡓ⮬↛ච␿ㄏᑟࡢศᏊᶵᵓࡢゎᯒி㒔኱Ꮫ࢘࢖ࣝࢫ࣭෌⏕་⛉Ꮫ◊✲ᡤ

ᩍᤵ

⸨⏣ࠉᑦᚿ

Innate immune responses against pathogen infection

Institute for Frontier Life and Medical Scienec, Kyoto
University

Professor

Takashi Fujita$VSHUJLOOXVIXPLJDWXV ࣜ࣎ࢯ࣮࣒ᶆⓗ⸆๣⪏ᛶᰴ࡟࠾ࡅࡿ஧ḟ௦ㅰάᛶ໬ᶵᵓࡢゎ᫂ᮾி኱Ꮫ኱Ꮫ㝔⥲ྜᩥ໬◊✲⛉

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㸲㸬 Activation of secondary metabolism in Aspergillus fumigatus strains with resistance to ribosometargeting chemicals
㸳㸬

Graduate School of Arts and Sciences,The University of
Associate Prof.
Tokyo

Antifungal drug resistance in Candida glabrata from transcriptional control to drug extrusion:aiming iBB-Institute for Bioengineering and Biosciences,improved diagnosis and therapeutics
Instituto Superior Técnico, University of Lisbon┿⳦⣽⬊ቨᡂศ࡟ᑐࡍࡿ⮬↛ච␿ᛂ⟅ᶵᵓࡢゎᯒ㸴㸬Studies on innate immune responses to the fungal cell wall component

Assistant Prof.

ዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫᩍᤵࣂ࢖࢜ࢧ࢖࢚ࣥࢫ◊✲⛉Graduate School of Biological Sciences, Nara Institute ofProfessor
Science and Technology

Teigo Asai
Miguel C TeixeiraἙྜࠉኴ㑻Taro Kawai&DQGLGDJODEUDWD ⣽⬊ቨᵓ⠏㛵㐃㑇ఏᏊḞᦆࡀ⳦యࡢᛶ㉁࡟ཬࡰࡍᙳ㡪ᮾ໭་⛉⸆⛉኱Ꮫ

ᩍᤵ

ᰘ⏣ࠉಙஅ

Deletion effect of genes related to the cell wall architecture of Candida glabreta

Tohoku Medical and Pharmaceutical University

Professor

Nobuyuki Shibata⸆๣⪏ᛶ࠾ࡼࡧឤཷᛶ$VSHUJLOOXVIXPLJDWXV ᰴࡢ௦ㅰ⏘≀ࡢ࣓ࢱ࣮࣒࣎ࣟゎᯒ

ᫍ⸆⛉኱Ꮫ

ᩍᤵ

⣽Ụࠉᬛኵ

Metabolome analysis based on fungal metabolites of drug-resistant mutant Aspergillus fumigatus

Hoshi University

Professor

Tomoo Hosoe㸵㸬㸶㸬࢔ࢫ࣌ࣝࢠࣝࢫࡢࣂ࢖࢜ࣇ࢕࣒ࣝᙧᡂ࠾ࡼࡧᢠ┿⳦⸆⪏ᛶ࡟㛵㐃ࡍࡿ᪂つ㑇ఏᏊ⩌ࡢ᥈⣴ ᅜ❧ឤᰁ⑕◊✲ᡤ

୺௵◊✲ᐁ

ᱵᒣࠉ㝯

Screening of novel genes involved in biofilm formation and antifungal resistance in Aspergillus fumigatNational Institute of Infectious Diseases

Senior scientist

Takashi Umeyama㸷㸬᪂つᢠ┿⳦๣ࡢྜᡂ࠾ࡼࡧάᛶホ౯◊✲ᮾி⌮⛉኱Ꮫ⌮Ꮫ㒊➨୍㒊ᛂ⏝໬Ꮫ⛉

ᩍᤵ

᳝ྡࠉຬ

Evaluation of antimicrobial and antifungal activity of New Macrolide, Eushearilide

Department of Applied Chemistry, Faculty of Science,
Tokyo University of Science

Professor

Isamu Shiina
ᱵᮧࠉ⯙Ꮚ

㸯㸮㸬
࢔ࢫ࣌ࣝࢠࣝࢫ⑕ཎᅉ⳦ࡀ⏘⏕ࡍࡿ⎔≧࣌ࣉࢳࢻࡢᐟ୺ච␿ᛂ⟅཯ᛂ࡬ࡢᙳ㡪⏘ᴗᢏ⾡⥲ྜ◊✲ᡤ୺௵◊✲ဨ

Effect of cyclic peptides produced by pathogenic Aspergillus species on host immune response

National Institute of Advanced Industrial Science andTechnology

Principal InvestigatoMaiko Umemura༓ⴥ኱Ꮫࡀಖ᭷ࡍࡿ࢜ࣜࢪࢼࣝ໬ྜ≀ࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸ࡓᢠ┿⳦⸆ࢩ࣮ࢬࡢ㛤Ⓨ༓ⴥ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉

ᩍᤵ

Ⲩ஭ࠉᏕ⩏

Development of antifungal seeds from chemical compound library owned by Chiba University

Graduate School of Science,Chiba University

Professor

Takayoshi Arai

Genetics Department, Harvard Medical School

research fellow,7$0ඹᙺཷᐜయ7UHPࡢ࢝ࣥࢪࢲឤᰁ㜵ᚚ࡟࠾ࡅࡿᙺ๭ࡢゎ᫂㮵ඣᓥ኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉

ᩍᤵ

ཎࠉࠉ༤‶

Studies on the role of the ITAM -coupled receptor Trem2 in anti-fungal defense

Kagoshima University Graduate School of Medical and
Dental Sciences

Professor

Hiromitsu Hara့ங㢮≉␗ⓗ࡞⮬↛ච␿ᛂ⟅ᶵᵓ࡜51$ࢧ࢖ࣞࣥࢩࣥࢢᶵᵓ࡟࠾ࡅࡿ┦஫స⏝ࡢゎ᫂ᮾி኱Ꮫ኱Ꮫ㝔⌮Ꮫ⣔◊✲⛉

෸ᩍᤵ

⛬ࠉஂ⨾Ꮚ

Molecular interaction between gene silencing and innate immune responses in mammaliam cells

Graduate School of Science, The University of Tokyo

Associate Prof.

Kumiko Ui-Tei⮫ᗋ᳨య࠿ࡽศ㞳ࡉࢀࡓࢸࣝࣅࢼࣇ࢕ࣥపឤཷᛶ ⪏ᛶ ⓑⓄ⳦ᰴ࡟࠾ࡅࡿ⪏ᛶ໬࣓࢝ࢽࢬ
ᖇி኱Ꮫ་┿⳦◊✲ࢭࣥࢱ࣮
࣒ࡢゎ᫂

෸ᩍᤵ

ᒣ⏣ࠉࠉ๛
Tsuyoshi Yamada

㸯㸯㸬

㸯㸰㸬
᪩㔝ࠉඖモ
㸯㸱㸬 Aging associated tissues dysfunction through regulation of micro-and mycobiota and metabolites

Motoshi Hayano
㸯㸲㸬

㸯㸳㸬

㸯㸴㸬

㸯㸵㸬

㸯㸶㸬

Study in mechanism of terbinafine resistance on Trichophyton clinical isolates

Teikyo University Institute of Medical Mycology

Associate Prof.

࢔ࢰ࣮ࣝ⣔㎰⸆ࢸࣈࢥࢼࢰ࣮ࣝ࡟ࡼࡿ㑅ᢥ࡛ᚓࡽࢀࡓ⪏ᛶ$VSHUJLOOXVIXPLJDWXV ᰴࡢゎᯒᖏᗈ␆⏘኱Ꮫື≀࣭㣗ရ᳨ᰝデ᩿ࢭࣥࢱ࣮

ㅮᖌ

㇏␃ࠉᏕோ

䠝䡊䠽䡈䡕sis of azole-resistant A.fumigatus clones selected with a fungicide,tebuconazole

Obihiro University of Agriculture and Veterinary
Medicine

Senior AssistantProfessor

Takahito Toyotome$VSHUJLOOXVIXPLJDWXV ࡢ⑓ཎᛶ࡟࠾ࡅࡿ࢞ࣛࢡࢺࣇࣛࣀ࣮ࢫྵ᭷⢾㙐ࡢᶵ⬟ゎᯒᓫᇛ኱Ꮫᛂ⏝ᚤ⏕≀ᕤᏛ⛉

෸ᩍᤵ

ᒸࠉᣅ஧

Functional analysis of galactofuranose-containing oligosaccharides in the pathogenicity of Aspergillus Department of Applied Microbial Technology, Sojo
fumigatus
University

Associate Prof.

Takuji Okaኳ↛໬ྜ≀ࣛ࢖ࣈ࣮ࣛࣜࢆ⏝࠸ࡓᢠ┿⳦⸆ࡢ㛤Ⓨ◊✲ᚤ⏕≀໬Ꮫ◊✲ᡤ㒊㛗஬༑ᔒࠉ㞞அ

Development of antifungal drugs from natural chemical compound library

Institute of Microbial Chemistry

Lab.Head

Masayuki Igarashiᮍ฼⏝ᚤ⏕≀ࢆ⣲ᮦ࡜ࡋࡓ᪂ࡋ࠸ᢠ┿⳦⸆ࢩ࣮ࢬࡢ᥈⣴᫛࿴⸆⛉኱Ꮫ

ᩍᤵஂಖ⏣ࠉ㧗᫂

Search for new antifungal drug seeds from unutilized microorganism

Showa Pharmaceutical University

Professor

Takaaki Kubota㹀㹁㹅ᮾிᰴ࡟ࡼࡿឤᰁ⑕ࡢ㎿㏿デ᩿࡜⑓ཎᛶ࡟㛵ࡍࡿ◊✲ᮾி་⛉኱Ꮫ

ᩍᤵ኱ᴋࠉΎᩥ

Molecular diagnosis and pathogenesis of Mycobacterium bovis BCG Tokyo strain

Tokyo Medical University

Professor

Kiyofumi Ohkusu

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㸰㸮㸬

㸰㸯㸬
ᑠඣ↓⭁⑕ᝈ⪅䛻䛚䛡䜛⫵⅖⌫⳦⾑Ύᆺ≉␗IgGᢠయ䞉䜸䝥䝋䝙䞁άᛶ䚸䜲䞁䝣䝹䜶䞁䝄⳦bᆺ㸰㸰㸬 ≉␗ᢠయ౯ಖ᭷≧ἣ䛻㛵䛩䜛᳨ウ
Pneumococcal IgG levels against 13-valent pneumococcal conjugate vaccine serotypes andHaemophilus influenzae type b IgG levels in Japanese children with asplenia&U\SWRFRFFXVQHRIRUPDQV ࡢࣘࢽ࣮ࢡ࡞ࢤࣀ࣒⥔ᣢᶵᵓࢆᶆⓗ࡜ࡋࡓ᪂つ἞⒪ᡓ␎ࡢ㛤Ⓨ࡟ྥࡅ࡚㸰㸱㸬
Towards development of novel therapeutic strategies targeting the unique mechanism of genome
maintenance in Cryptococcus neoformans༓ⴥ┴䛣䛹䜒⑓㝔

㒊㛗

ᫍ㔝䚷䚷┤

Chiba Children’s Hospital

Section Head

Tadashi Hoshino༓ⴥ኱Ꮫ኱Ꮫ㝔⼥ྜ⛉Ꮫ◊✲⛉ᩍᤵGraduate School of Advanced Integration Science, Chiba
Professor
University

ᯇᾆᙲAkira Matsuura࣐࢘ࢫឤᰁ᫬࡟㉳ࡇࡿ⑓ཎ⣽⳦㑇ఏᏊⓎ⌧ࡢ⥙⨶ⓗゎᯒ༓ⴥ኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲㝔

෸ᩍᤵ

㧗ᒇࠉ᫂Ꮚ

Transcriptome analysis of Salmonella Typhimurium during infection of mouse

Graduate School of Pharmaceutical Science, Chiba
University

Associate Prof.

Akiko Takaya㸰㸬⭠ෆ⣽⳦ྀ࡜⭠ෆ┿⳦ࡢ┦஫స⏝࡟ࡼࡾᵓ⠏ࡉࢀࡿ⢓⭷ච␿ࢩࢫࢸ࣒ࡢゎ᫂ࢽ࣮࣮ࣗࣚࢡ኱Ꮫ་Ꮫ㒊ࢫ࣮࢝࣎ࣝ◊✲ᡤ

༤ኈ◊✲ဨ

బ㔝ࠉ᫭அ

Understanding the intestinal immune responses orchestrating by gut microbiota and mycobacteria

New York University,School of Medicine Skirball
Institute of Biomolecular Medicine

Postdoctoral
researcher

Teruyuki Sano&DQGLGDJODEUDWD ࡟࠾ࡅࡿ࣑ࢺࢥࣥࢻࣜ࢔㑅ᢥⓗ࣮࢜ࢺࣇ࢓ࢪ࣮άᛶ᳨ฟ⣔ࡢ㛤Ⓨᅜ❧ឤᰁ⑕◊✲ᡤ

◊✲ဨ

ྡᮌࠉࠉ⛱

Measurement of mitophagic activity in Candida glabrata

National Institute of Infectious Diseases

Research Scientist Minoru Nsgi

㸰㸳㸬

㸰㸴㸬
࣐࢘ࢫ⣽⳦ᛶ⫵⅖ࣔࢹࣝ࡟࠾ࡅࡿࢩ࣋ࣞࢫࢱࢵࢺ࡜ࢺࣟࣥ࣎ࣔࢪࣗࣜࣥ࡟ࡼࡿ⅖⑕཯ᛂไ༓ⴥ኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲㝔ᚚ㸰㸵㸬 Regulation of inflammatory response with sivelestat and thrombomodulin in murine bacterial
Graduate School of Medicine, Chiba University
pneumina model

෸ᩍᤵ

Ώ㑓ࠉᰤ୕

Associate Prof.

Eizo Watanabe$VSHUJLOOXVIXPLJDWXV 㛵㐃✀ࡢ᪥ᮏᅜෆ࡟࠾ࡅࡿศᕸࡢᐇែゎ᫂᪥ᮏ኱Ꮫ⸆Ꮫ㒊

෸ᩍᤵ

ᘅ℩ࠉࠉ኱

Investigation of distribution on the related species of Aspergillus fumigatus in Japan

School of Pharmacy, Nihon University

Associate Prof.

Dai Hiroseಖ⫱ᅬඣ࠿ࡽศ㞳ࡉࢀࡿ⫵⅖⌫⳦↓Ⳓ⭷ᰴࡢ⑓ཎᛶゎᯒ࿴⏣ᑠඣ⛉་㝔㝔㛗࿴⏣ࠉ⣖அ

Director

Noriyuki Wada

㸰㸶㸬

㸰㸷㸬
Pathogenesis of non-encapsulated Streptococcus pneumoniae isolated from children in nursery school Wada Shounikaiin

19୺せ◊✲ᶵჾ࣭タഛ࡟ࡘ࠸࡚
Research Equipment and Facilitiesᮏࢭࣥࢱ࣮࡛ࡣࠊ௨ୗࡢࡼ࠺࡞◊✲ᶵჾࡸタഛࡀ฼⏝ྍ⬟࡛ࡍࠋࡇࢀࡽࡣࠊඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬࡢ◊✲ㄢ㢟ࡔࡅ࡛࡞ࡃࠊᵝࠎ࡞◊✲άື࡟౑⏝ࡋ࡚࠸ࡓࡔࡃࡇ࡜ࡀ࡛ࡁࡲࡍࠋࡑࢀࡒࢀࡢᶵჾ࠾ࡼࡧタഛࡢᢸᙜᩍဨࢆグ㍕ࡋ࡚࠶ࡾࡲࡍࡢ࡛ࠊ࠾ၥ࠸ྜࢃࡏࡢ࠺࠼ࡈ฼⏝ࡃࡔࡉ࠸ࠋMMRC provides the following research equipment and facilities for domestic and foreign researchers.
Please contact the relevant faculty members to use our research equipment.
Ӑ㟁ヰ㸦TEL㸧㸸043-222-7171㸦௦⾲ : Key number㸧ӑ୺せ◊✲ᶵჾ 㸦Research Equipment㸧(1) ḟୡ௦ࢩ࣮ࢣࣥࢧ࣮㸦Next Generation Sequencer, Illumina Misep㸧㸦㧗ᶫ㸦୰ཱྀ㸧ෆ⥺ 5924㸧

(2) ࢔ࢥ࣮ࢫࢸ࢕ࢵࢡࢯࣝࣅࣛ࢖ࢨ࣮
㸦M&S Instruments, Covaris㸸㧗ᶫ㸦୰ཱྀ㸧ෆ⥺ 5924㸧

(3) DNA ᩿∦໬⿦⨨ ࣁ࢖ࢻࣟࢩ࢙࢔

㸦Asahi Life Science, DIGILAB㸸㧗ᶫ㸦୰ཱྀ㸧ෆ⥺ 5924㸧

MiSeq(4) 㑇ఏᏊࢹ࣮ࢱゎᯒࢩࢫࢸ࣒㸦Genetic analyzer㸧㸦▮ཱྀ ෆ⥺ 5918㸧
ձ ABI Prism 3130 Genetic analyzer 673-A
ղ ABI Prism 3130N(5) 㢧ᚤ㙾㸦Microscope㸧ձ ㏱㐣㟁Ꮚ㢧ᚤ㙾㸦JEOL, JEM-1400㸸ᒣཱྀ ෆ⥺ 5964㸧
ղ ㉮ᰝ㟁Ꮚ㢧ᚤ㙾㸦HITACHI, S-3400N㸸▮ཱྀ ෆ⥺ 5918㸧

ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾ճ ⴠᑕ⺯ගᚤศᖸ΅㢧ᚤ㙾㸦Nikon, Y-FL㸸⏣୰ ෆ⥺ 5916㸧
մ ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾㸦Zeiss, LSM 5 EXCITER㸸኱ᴋ ෆ⥺ 5941㸧
յ ࣮࢜ࣝ࢖ࣥ࣡ࣥ⺯ග㢧ᚤ㙾⿦⨨
㸦KEYENCE, BZ-9000㸸ᑿ㔝ᮏ ෆ⥺ 5919㸧

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(7) ࢘ࣝࢺ࣑ࣛࢡࣟࢺ࣮࣒㸦Leica, Ultracut S㸸ᒣཱྀ ෆ⥺ 5964㸧

㏱㐣㟁Ꮚ㢧ᚤ㙾(8) ࢧ࢖ࢺ࣓࣮ࢱ࣮㸦Cytometer㸧ձ ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥࢧ࢖ࢺ࣓࣮ࢱ࣮㸦OLYMPUS, LSC-101㸸኱ᴋ ෆ⥺ 5941㸧
ղ ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮㸦On-chip, FISHMAN-R㸸⏣୰ ෆ⥺ 5916㸧
(9) PCRձ ࣜ࢔ࣝࢱ࢖࣒ PCR 㸦Roche, Lightcycler 96㸸㧗ᶫ㸦୰ཱྀ㸧ෆ⥺ 5924㸧
ղ ࣜ࢔ࣝࢱ࢖࣒ PCR 㸦ABI, PRISM 7300㸸ᮧ㛗 ෆ⥺ 5912㸧ճ ࢧ࣮࣐ࣝࢧ࢖ࢡ࣮ࣛ㸦Takara, MPTF-3100㸸㙑⏣ ෆ⥺ 5941㸧

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(10)ศගගᗘィཬࡧ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮㸦Spectrophotometer & Image Analyzer㸧ձ ⏕≀Ⓨග࣭໬ᏛⓎග࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜࢲ࣮㸦Perceptive Biosystems 400㸸㙑⏣ ෆ⥺ 5941㸧
ղ ࣑ࣝࣀ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮㸦Fujifilm, LAS-1000UVmini㸸ᑿ㔝ᮏ ෆ⥺ 5919㸧
ճ ࣇࣝ࢜ࣟ࢖࣓࣮ࢪ࢔ࢼࣛ࢖ࢨ࣮㸦Fujifilm, FLA-7000㸸⏣୰ ෆ⥺ 5916㸧
մ ྾ග࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜࢲ࣮㸦TECAN, Sunrise Thermo㸸ᖖ႐ ෆ⥺ 5919㸧
յ ࣁ࢖ࢥࣥࢸࣥࢶ࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒㸦Operetta㸸ᮧ㛗 ෆ⥺ 5912㸧ն ࣑ࣝࣀ࢖࣓࣮ࢪࣥࢢ࢔ࢼࣛ࢖ࢨ࣮ 㸦GE, LAS4000:▮㒊 ෆ⥺ 5928㸧

(11)㐲ᚰᶵ㸦Centrifuge㸧ձ ከᶵ⬟ᚤ㔞㧗㏿㐲ᚰᶵ㸦Beckman, Allegra X-12㸸㧗ᶫ㸦୰ཱྀ㸧ෆ⥺ 5924㸧
ղ ༟ୖ㉸㐲ᚰᶵ㸦Beckman, OptimaTLX㸸ᑿ㔝ᮏ ෆ⥺ 5919㸧
ճ ㉸㐲ᚰᶵ㸦᪥❧ᕤᶵ, CPX100MX:ᖖ႐ ෆ⥺ 5919㸧
մ 㧗ᶵ⬟㧗㏿෭༷㐲ᚰᶵ㸦࣋ࢵࢡ࣐ࣥࢥ࣮ࣝࢱ࣮, Avanti HP-26XP:ᖖ႐ ෆ⥺ 5919㸧

(12)㑇ఏᏊᑟධ⿦⨨㸦Bio-Rad, PDS-1000/He㸸኱ᴋ ෆ⥺ 5941㸧

(13)࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝㸦YASUI KIKAI, MU601U㸦S㸧:኱ᴋ ෆ⥺ 5941㸧

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(15)ᐇ㦂ື≀⏝ X ⥺ CT ⿦⨨㸦Hitachi-Aloka Medical, Latheta LCT200㸸ᮧ㛗 ෆ⥺ 5912㸧

(16)㧗㏿ᾮయࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮HPLC㸦SHIMAZU CTO-10A VP㸸▮ཱྀ ෆ⥺ 5918㸧

ᐇ㦂ື≀⏝ X ⥺ CT ⿦⨨୺せ◊✲タഛ㸦Research Facilities㸧
(1) ኱つᶍ PC ࢡࣛࢫࢱࢩࢫࢸ࣒㸦Large scale PC Cluster System㸸㧗ᶫ ෆ⥺ 5909㸧

(2) SPF ື≀ឤᰁᐇ㦂ᐊ㸦SPF laboratory animal facility for experimental infections㸸すᇛ ෆ⥺ 5934㸧

(3) BSL3 ᑐᛂᐇ㦂ᐊ㸦BSL3-compliant laboratory㸸ட஭ ෆ⥺ 5911㸧

SPF ື≀ឤᰁᐇ㦂ᐊ

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PC ࢡࣛࢫࢱࢩࢫࢸ࣒

኱Ꮫ㝔࡟࠾ࡅࡿ◊✲ᣦᑟཬࡧⱝᡭ◊✲⪅ࡢ⫱ᡂ =   ^ <`> ᮏࢭࣥࢱ࣮ࡣࠊᡃࡀᅜ࡛၏୍ࠊḟୡ௦ࡢ┿⳦་Ꮫ◊✲⪅ࢆ⫱ᡂࡍࡿ㔜せ࡞౑࿨ࢆᢸࡗ࡚࠾ࡾࠊᅜෆ࠾ࡼࡧᅜእ
࠿ࡽከࡃࡢ኱Ꮫ㝔⏕ࡸ◊✲⏕ࢆཷࡅධࢀࠊᩍဨࡀ◊✲ࡢ⌧ሙ࡛◊✲ᣦᑟࢆ┤᥋⾜ࡗ࡚࠸ࡲࡍࠋᏛෆ࡛ࡣࠊᖹᡂ !'ᖺᗘ㸦!"#! ᖺ㸧࡟᥇ᢥࡉࢀࡓᩥ㒊⛉Ꮫ┬༤ኈㄢ⛬ᩍ⫱࣮ࣜࢹ࢕ࣥࢢࣉࣟࢢ࣒ࣛࠕච␿ࢩࢫࢸ࣒ㄪ⠇἞⒪Ꮫ᥎㐍࣮ࣜࢲ࣮㣴ᡂࣉࣟࢢ࣒ࣛࠖ࡬ཧ⏬ࡋࠊᅜ㝿ⓗ࡞࣮ࣜࢲ࣮ࡢ⫱ᡂ஦ᴗ࡟㈉⊩ࡋ࡚࠸ࡲࡍࠋࡲࡓእ㒊࠿ࡽ◊✲⪅ࢆᣍࡁࠊࢭ࣑ࢼ࣮ࡸࢩ࣏ࣥࢪ࣒࢘ࢆ✚ᴟⓗ࡟㛤ദࡋ࡚࠸ࡲࡍࠋࡉࡽ࡟ࠊ༓ⴥ኱Ꮫ࡛ᖹᡂ !" ᖺᗘࡼࡾᑟධࡉࢀࡓࢸࢽ
ࣗ࢔ࢺࣛࢵࢡไᗘࢆά⏝ࡋ࡚ࠊⱝᡭ◊✲⪅ࡢ⮬❧ᨭ᥼࡟✚ᴟⓗ࡟ྲྀࡾ⤌ࢇ࡛࠸ࡲࡍࠋᅜෆእ࠿ࡽࡢⱝᡭ◊✲⪅ࢆཷࡅධࢀࠊ◊✲ࡢᅜ㝿஺ὶࢆಁ㐍ࡍࡿ࡜࡜ࡶ࡟ࠊᖐᅜᚋࡶ◊✲ᣦᑟࢆ⥅⥆ࡋࠊඹྠ◊✲ᡂᯝࢆㄽᩥ࡜ࡋ࡚Ⓨ⾲ࡋ࡚ࡁࡲࡋࡓࠋࢭࣥࢱ࣮࡛ࡣࠊᩍ⫋ဨࡀ୍୸࡜࡞ࡗ࡚ⱝᡭ◊✲⪅࣭኱Ꮫ㝔⏕ࡢ◊✲࣭ᩍ⫱࡟ດຊࡋ࡚࠸ࡲࡍࠋ  *+  <      => <?  <*   ?  <   ?<?@ Q   =<* > =   <? ? + <   +=[@\ ? *<?] ?  *?
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ឤᰁᐇ㦂

ࢹ࢕ࢫ࢝ࢵࢩࣙࣥ

ಟኈㄢ⛬ # ᖺ ᯇᑿ ㅬⶶᏛ㒊 ' ᖺ⏕ ⟄ሙ ༓✑ ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ࡢ㨩ຊࡣ࡞ࢇ࡜࠸ࡗ࡚ࡶ ┿⳦ࢭࣥࢱ࣮ࡣඛ㍮ࡸඛ⏕᪉࡜ࡢ㊥㞳ࡀ㏆ࡃࠊẼ◊✲ᐊ㛫ࡢ௰ࡀⰋ࠸ࡇ࡜ࡔ࡜ᛮ࠸ࡲࡍࠋ◊✲ᐊෆࡢ㍍࡟㉁ၥࢆฟ᮶ࡿ⎔ቃ࡟࠶ࡿࡢ࡛ࠊணഛ▱㆑ࡀṤ࡝ࡳ࡞ࡽࡎ௚ࡢ◊✲ᐊࡢඛ⏕᪉ࠊᏛ⏕࡜ࡶࢥ࣑ࣗࢽࢣ

࡞࠿ࡗࡓ⚾࡛ࡶᴦࡋࡃ◊✲ࢆ㐍ࡵࡿࡇ࡜ࡀฟ᮶࡚࠸

࣮ࢩࣙࣥࡀྲྀࡾࡸࡍࡃࠊ◊✲࡟㛵ࡍࡿ࢔ࢻࣂ࢖ࢫࢆ

ࡲࡍࠋࡲࡓࠊ◊✲ᐊࡸࢭࣥࢱ࣮ࠊ኱Ꮫࡢᇉ᰿ࢆ㉺࠼㡬࠸ࡓࡾࠊ᫬࡟ࡣ୍⥴࡟ࡈ㣤ࢆ㣗࡭࡟⾜ࡗࡓࡾࡋࡲ

࡚ヰࢆ⪺ࡃᶵ఍࡟ᜨࡲࢀ࡚࠸ࡿࡓ

ࡍࠋᑓ㛛௨እࡢᖜᗈ࠸▱㆑ࢆᚓࡽ

ࡵࠊ◊✲ࢆࡍࡿ࡟࠶ࡓࡗ࡚ࡢど㔝ࢀࡿࡔࡅ࡛࡞ࡃࠊ㡹ᙇࡗ࡚࠸ࡿ௚

ࢆᗈࡃᣢࡘࡇ࡜ࡀฟ᮶ࡿࡇ࡜ࡶ

ࡢᏛ⏕ࡢጼ࡟ゐⓎࡉࢀ⮬㌟ࡶ᪥ࠎ㨩ຊࡔ࡜ᛮ࠸ࡲࡍࠋ

◊✲࡟㞟୰ࡋ㡹ᙇࡿࡇ࡜ࡀ࡛ࡁ࡚
࠸ࡲࡍࠋ

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ᅜ㝿஺ὶ༠ᐃ㸦኱Ꮫ㛫஺ὶ༠ᐃ࣭㒊ᒁ㛫஺ὶ༠ᐃ࡞࡝㸧Inter-University and Faculty-level Exchange Agreementsᅜ㝿ⓗ࡞◊✲άືࡢ᥎㐍ࡣ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮ࡢ኱ࡁ࡞ࢸ࣮࣐ࡢ୍ࡘ࡛࠶ࡿࡇ࡜࠿ࡽࠊᅜ㝿஺ὶ㺂ᅜ㝿ඹྠ◊✲࡟ࡣ≉࡟ຊࢆධࢀάⓎ࡟᥎㐍ࡋ࡚࠸ࡿࠋලయⓗ࡞༠ᐃ࡜ࡋ࡚ࡣࣁ࣮ࣥ࢞ࣜඹ࿴ᅜࢹࣈࣞࢶ࢙ࣥ኱Ꮫ㸦1996
ᖺ㹼㸧ࡸࣈࣛࢪࣝ㐃㑥ඹ࿴ᅜᕞ❧࢝ࣥࣆ࣮ࢼࢫ኱Ꮫ㸦UNICAMP㸧㸦2001ᖺ㹼㸧࡞࡝࡜ࡢ㛫࡟኱Ꮫ㛫஺ὶ༠ᐃࡀ
࠶ࡾࠊࡲࡓࠊᾏእࡢᏛ㒊࣭㒊ᒁ࡜ࡢ㒊ᒁ㛫஺ὶ༠ᐃ࡜ࡋ࡚ࡣࠊ୰ᅜྜྷᯘ኱Ꮫⓑồᜠ་Ꮫ㝔་Ꮫ㝔㸦2008ᖺ㹼㸧ࠊ㈗ᕞ་⛉኱Ꮫ㸦2009ᖺ㹼㸧ࠊ୰ᅜ᪂␩་⛉኱Ꮫ㝃ᒓ➨1⑓㝔㸦2010ᖺ㹼㸧ࠊࣈࣛࢪࣝᅜࢧࣥࣃ࢘ࣟᕞ❧኱Ꮫࢧࣥࣃ
࢘ࣟᰯ་Ꮫ㒊㸦2012ᖺ㹼㸧࡞࡝ࡀ࠶ࡿࠋ࠸ࡎࢀࡢ༠ᐃ⥾⤖ඛ࡜ࡶάⓎ࡞ඹྠ◊✲ࢆ⥅⥆ࡋ࡚࠸ࡿࡀࠊ≉࡟
UNICAMP࡟ࡘ࠸࡚ࡣࠊ㏻ᖖࡢඹྠ◊✲࡟ຍ࠼࡚H.28ᖺᗘࡼࡾSATREPS࡟ࡼࡿඹྠ◊✲ࢆ㛤ጞࡍࡿ࡞࡝άⓎ࡞άືࢆᒎ㛤ࡋ࡚࠸ࡿࠋ᮶ゼ⪅࡜ࡋ࡚ࡣᖹᡂ26ᖺᗘ࡟ࡣࢣࢽ࢔ඹ࿴ᅜ Kenya Medical Research Institute㸦KEMRI㸧࡞࡝ࠊ27ᖺᗘ࡟ࡣ࣏ࣝࢺ࢞ࣝඹ࿴ᅜࣜࢫ࣎ࣥ኱Ꮫ࡞࡝࠿ࡽ◊✲⪅ࢆཷࡅධࢀࠊࡉࡽ࡟᪂␩་⛉኱Ꮫ࡞࡝࠿ࡽ኱Ꮫ㝔⏕࠶ࡿ࠸ࡣ◊✲⏕࡜ࡋ࡚◊✲⪅ࢆཷධࢀࡿ࡞࡝㺂ᅜ㝿ඹྠ◊✲ࢆ✚ᴟⓗ࡟᥎㐍ࡋ࡚࠸ࡿࠋ

We have performed collaborative research with a number of universities and faculties around the world;
these include Xinjiang Medical University (China), Jilin University (China), Guiyang Medical College(China), the University of Campinas (UNICAMP, Brazil), and the Sao Paulo State University(UNESP,Brazil). These efforts are based on inter-university and inter-faculty-level exchange contracts.
With UICAMP, in particular, the collaboration has been further enhanced by starting SATREPS project in2016. By establishing these international relations, we are working actively with these
institutes/universities and numerous new findings were published in high impact journals. We also takegraduate students/research students from abroad.

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ᅜ㝿ⓗ࡞ඹྠ◊✲ဨ➼ཬࡧᏛ⏕ࡢཷධ≧ἣ
Number of International Joint Researchers and Students‫ڦ‬ᅜ㝿ⓗ࡞ඹྠ◊✲ဨ➼ࡢཷධ≧ἣ(Number of International Joint Researchers)
༊  ศ
 ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘእᅜே◊✲ဨ(International Research Scientist)
㸮
㸮
㸮
㸮
㸮
እᅜே◊✲⪅(International Researcher)
㸲
㸮
㸯
㸯
㸮
ᅜ㝿༠ຊᶵᵓ࡟ࡼࡿཷධ(Joint Researcher from JICA)
㸲
㸮
㸮
㸮
㸮
ࡑࡢ௚(Other)
㸮
㸮
㸮
㸮
㸮


‫ڦ‬Ꮫ⏕ࡢཷධ≧ἣ(Number of Students)
༊  ศ
 ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ  ᖺᗘ◊ ✲ ⏕(Research Student)
㸮
㸮
㸯
㸯
㸰
◊✲␃Ꮫ⏕(International Research Student)
㸮
㸮
㸯
㸰
㸯
་Ꮫ⸆Ꮫᗓ
㸯㸰
㸯㸮
㸷
㸯㸯
㸯㸱
(Medical and Pharmaceutical Sciences)኱Ꮫ㝔⏕(Graduate Student)⼥ྜ⛉Ꮫ◊✲⛉㸯㸯㸮㸮㸮(Advanced Integration Science)
Ꮫ 㒊 ⏕(Undergraduate Student)
㸱
㸴
㸳
㸱
㸰
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㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᣐⅬᾏእᣐⅬ㐃ᦠඹྠ◊✲
Cooperative Research of Priority Areas with NEKKEN, Nagasaki Universityࠕ࢔ࣇ࡛ࣜ࢝Ⓨ⏕ࡋ࡚࠸ࡿ┿⳦⑕࣭ᨺ⥺⳦⑕ࡢཎᅉ⳦ࡢ཰㞟࡜ᙧែᏛⓗࠊ⏕⌮ᏛⓗࠊศᏊ⏕≀Ꮫⓗゎᯒࠖࣉࣟࢪ࢙ࢡࢺ
㛗ᓮ኱Ꮫ⇕ᖏ་Ꮫ◊✲ᡤࢣࢽ࢔ᣐⅬࡢຓຊࢆᚓ࡚ࠊࢣࢽ࢔ᅜ࿘㎶ࡢ㣗⣊ࡢ࢝ࣅẘởᰁࡸࣄࢺ┿⳦⑕࡟㛵ࡍࡿࣉࣟࢪ࢙ࢡࢺࢆᒎ㛤ࡋ࡚࠸ࡲࡍࠋ⌧ᅾࡲ࡛࡟ࢣࢽ࢔඲ᅵࡢ୺せ✐≀㸦ࢺ࢘ࣔࣟࢥࢩࠊᑠ㯏㸧ࡸ࣑ࣝࢡ࡞࡝ࢆởᰁࡍࡿ࢝ࣅẘ㸦Ⓨࡀࢇᛶ࢔ࣇࣛࢺ࢟ࢩࣥ௚㸧࡜ࡑࡢ⏕⏘⳦ࡢゎᯒࢆ㐍ࡵࠊ⌧ᆅ㣗≀ࡢከࡃࡀࠊୡ⏺ࡢᏳ඲ᇶ‽್ࢆ኱ࡁࡃୖᅇࡿ࢝ࣅẘ࡛ởᰁࡉࢀ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ⤖ᯝࡣࠊ⌧ᆅࡢ࣐ࢫࢥ࣑࡟ࡶྲྀࡾୖࡆࡽࢀࠊ኱ࡁ
࡞཯㡪ࢆ࿧ࡧ㉳ࡇࡋࡲࡋࡓࠋࡲࡓ⌧ᆅ࡟⁫ᅾࡍࡿ⡿ᅜ་ᖌࡽ࡜༠ຊࡋࠊ࢚࢖ࢬᝈ⪅ࡢ࿨ࢆዣ࠺୺࡞ཎᅉ࡛࠶ࡿ┿⳦ឤᰁ⑕ࠊ≉࡟ࢡࣜࣉࢺࢥࢵ࢝ࢫᒓ⳦࡟ࡼࡿឤᰁࢆ୰ᚰ࡟␿Ꮫⓗㄪᰝࢆィ⏬ࡋ࡚࠸ࡲࡍࠋࡉࡽ࡟⎔ቃ୰ࡢ࢔ࢫ࣌
ࣝࢠࣝࢫ⑕ཎᅉ⳦✀ࡢᢠ┿⳦⸆࡟ᑐࡍࡿ⪏ᛶࠊ⪏ᛶ㒊఩࡞࡝ࡢㄪᰝࡶጞࡵࡲࡋࡓࠋᾏእ࡛ࡢ◊✲ࡣࠊ⌧ᆅࡢ◊✲⪅ࡸ┘╩ᐁᗇ࡜ಙ㢗㛵ಀࢆ⠏ࡁࠊチྍࢆᚓࡿ࡞࡝ከࡃࡢၥ㢟ࢆゎỴࡋ࡞ࡅࢀࡤ๓㐍࡛ࡁࡲࡏࢇࠋࡋ࠿ࡋࠊ⌧ᆅࡢ
་⒪࡟㈉⊩ࡋࠊேࠎࡢ⏕άࡢ㉁㸦QOL㸧ࡢྥୖࢆᅗࡾࠊࡉࡽ࡟᪥ᮏ࡜ࡢ཭ዲࢆ῝ࡵࡿࡓࡵ࡟ດຊࢆ㔜ࡡ࡚࠸ࡲࡍࠋ
Project for Collections, and morphological, physiological and molecular biological analysis of humanpathogenic fungi and actinomycetes in Africa.
Under assistance of Kenya Research Station, Inst. NEKKEN, Nagasaki univ., we are analyzing
toxins contaminating major local grains (maze, wheat) and milks, and also producer fungi. We foundthe local foods are contaminated by the toxins at concentrations far above the international standards.
The result has been announced in newspapers, and received large attention. A new project for
epidemiological study of Cryptococcal fungi in HIV-infected patients is launched in collaboration with
Kenya Medical Res. Institute (KEMRI) and doctors from UCSF, USA.

$0('-,&$ ᆅ⌫つᶍㄢ㢟ᑐᛂᅜ㝿⛉Ꮫᢏ⾡༠ຊࣉࣟࢢ࣒ࣛ 6$75(36AMED/JICA Science and Technology Research Partnership for Sustainable Development (SATREPS)㺀ࣈࣛࢪࣝ࡜᪥ᮏࡢ⸆๣⪏ᛶࢆྵࡴ┿⳦ឤᰁ⑕デ᩿࡟㛵ࡍࡿ◊✲࡜ࣜࣇ࢓ࣞࣥࢫ༠ຊయไᙉ໬ࣉࣟࢪ࢙ࢡࢺ㺁┿⳦ឤᰁ⑕ᝈ⪅ࡣୡ⏺ⓗ࡟ᛴቑࡋ࡚࠸ࡿࠋ࡜ࡃ࡟⸆๣⪏ᛶ┿⳦࡟ࡼࡿឤᰁ⑕ࡣ⸆๣ឤᛶ⳦࡟ࡼࡿࡶࡢ࡜ẚ
㍑ࡋ࡚἞⒪ኻᩋ⋡ࡀ㧗࠸ࠋ┿⳦ࡀ⪏ᛶࢆ⋓ᚓࡍࡿ࣓࢝ࢽࢬ࣒࡟ࡘ࠸࡚ࡣ༑ศ࡟ゎ᫂ࡉࢀ࡚࠸࡞࠸ࡀࠊ㎰ᆅ࡟ᩓᕸࡉࢀࡿ㎰⸆㸦ᢠ┿⳦⸆㢮ఝࡢᡂศࢆྵࡴ㸧ࡢᙳ㡪࡟ࡼࡿࡶࡢࠊ៏ᛶ┿⳦ឤᰁ⑕ᝈ⪅࡟ᑐࡍࡿ࢔ࢰ࣮ࣝ⣔ᢠ┿⳦⸆ࡢ㛗ᮇ౑⏝࡞࡝ࡀཎᅉ࡜ࡋ࡚⪃࠼ࡽࢀ࡚࠸ࡿࠋࡑࡢ୍᪉ࠊࣈࣛࢪ࡛ࣝࡣ⸆๣⪏ᛶ┿⳦ࡢᐇែࡣ༑ศ
ゎ᫂ࡉࢀ࡚࠸࡞࠸≧ἣ࡟࠶ࡿࠋᮏ◊✲࡛ࡣࠊࣈࣛࢪࣝࡢࢧࣥࣃ࢘ࣟᕞ❧࢝ࣥࣆ࣮ࢼࢫ኱Ꮫ࡜㐃ᦠࡋࠊ࢝ࣥࣆ
࣮ࢼࢫ㤳㒔ᅪ࡟࠾ࡅࡿ⪏ᛶ┿⳦࡟ࡼࡿឤᰁ⑕ࡢᐇែࢆ᫂ࡽ࠿࡟ࡋࠊ⪏ᛶ┿⳦ࡢ᳨ฟἲࢆ㛤Ⓨࡍࡿࡇ࡜ࢆ㏻ࡌࠊ
᪥ᮏ࠾ࡼࡧࣈࣛࢪࣝ࡟࠾ࡅࡿ㞴἞ᛶ┿⳦ឤᰁ⑕ࡢࣜࣇ࢓ࣞࣥࢫయไࢆᵓ⠏ࡍࡿ࡜࡜ࡶ࡟⪏ᛶ┿⳦ឤᰁ⑕◊✲ᣐⅬ◊✲ࢿࢵࢺ࣮࣡ࢡࡢᵓ⠏ࢆ┠ᣦࡍࠋ 

͆The Project for the Establishment of a Research and Reference Collaborative System for the
Diagnoses of Fungal Infections including Drug-Resistant Ones both in Brazil and Japan”
The number of patients with fungal infection (FI) is increasing worldwide. The rate of treatment
failure on the drug-resistant FI is higher than the one on the drug-susceptible FI. The mechanism how
fungus gains resistance has not been thoroughly clarified, however, it could be through the exposure topesticides containing ingredients similar to medical antifungal drugs in the fields (fungicides), or in the
body of a patient with chronic FI who has undergone a treatment using antifungals for a long time.
There are few public data in Brazil that shows the frequency of drug-resistant fungi. We planned our
project in collaboration with the State University of Campinas in Brazil (UNICAMP). Aims of our
project are to clarify the situation of drug-resistant FI in Campinas Metropolitan area, develop a new
detection method for the drug resistant fungi and establish a reference system for refractory FI andresearch network regarding the drug-fungi in Japan and Brazil. 
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㧗㱋⪅࣭᪂⏕ඣ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ไᅽ࡬ྥࡅࡓண㜵࣭デ᩿࣭἞⒪㛤Ⓨࣉࣟࢪ࢙ࢡࢺ
ࠕProject for the development of preventive, diagnostic and therapeutic measures against aspergillosis
in the elderly people and high-risk neonatesࠖ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࡣṚஸ⪅ᩘࡢ᭱ࡶከ࠸㔜⠜࡞┿⳦⑕࡛࠶ࡿࠋᡃࡀᅜ࡛ࡣ♫఍ࡢ㧗㱋໬ࡸ COPD㸦៏ᛶ㛢ሰᛶ⫵⑌ᝈ㸧ࡢቑຍ࡟ࡼࡾࠊ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࡢᝈ⪅ᩘࡀ᭦࡟ቑຍࡍࡿࡇ࡜ࡀᠱᛕࡉࢀ࡚࠸ࡿࡀࠊຍ࠼࡚⪏ᛶ⳦ࡢᛴቑࡶ⌧ᐇࡢࡶࡢ࡜࡞ࡾࡘࡘ
࠶ࡾࠊ༴ᶵⓗ࡞≧ἣࢆ㔊ࡋฟࡋ࡚࠸ࡿࠋ୍᪉㸪ᑠඣ⛉㡿ᇦ࡛ࡣ㸪᪂⏕ඣ࡟࠾ࡅࡿ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࢆࡣࡌࡵ࡜ࡋ࡚ࠊ┿⳦⑕ࡢᐇែࡣ඲ࡃ୙࡛᫂࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ COPD ࡞࡝ࡢ៏ᛶ⫵⑌ᝈ࡟ేⓎࡍࡿࡇࢀࡽࡢ┿⳦⑕ࡢゎᯒࢆ⾜࠺࡜࡜ࡶ࡟ࠊ᪂⏕ඣࢆ୺࡞ᑐ㇟࡜ࡋࡓ␿Ꮫㄪᰝࢆ⾜࠸ࠊ᪂つデ᩿ἲࠊ἞⒪ἲࠊண㜵ἲࡢ㛤Ⓨࢆ⾜ࡗ࡚ᮏ⑌ᝈࡢไᅽࢆ┠ᣦࡍࠋࡇࢀࡲ࡛࡟ COPD
࡟ྜేࡍࡿ࢔ࢫ࣌ࣝࢠࣝࢫ⑕࡟ࡘ࠸࡚៞᠕኱Ꮫ⑓㝔࡜ࡢඹྠ␿Ꮫ◊✲ࢆ㛤ጞࡋࠊ࢔ࢫ࣌ࣝࢠࣝࢫ࡟ឤసࡉࢀࡓ COPD ᝈ⪅࡟࠾ࡅࡿ⫵ᶵ⬟ࡢపୗഴྥࢆぢ࠸ࡔࡋࡓࠋࡲࡓ཰㞟ࡋࡓ࢔ࢫ࣌ࣝࢠࣝࢫᰴࡢ୰࡟ᡃࡀᅜึ࡜࡞ࡿ⪏ᛶᶵᵓࢆⓎぢࡋࠊ᭦࡟」ᩘࡢ⪏ᛶᶵᵓࢆ᭷ࡍࡿ⳦ᰴࢆ཰㞟࣭ゎᯒࡍࡿ࡞࡝᳨ウࢆ㐍ࡵ࡚࠸ࡿࠋ୍᪉ࠊ᪂⏕ඣࡢ┿⳦⑕࡟ࡘ࠸࡚ࡣ᪥ᮏ᪂⏕ඣᡂ⫱་Ꮫ఍ࡢ༠ຊ
ࢆᚓ࡚ࠊ඲ᅜࡢ࿘⏘ᮇ◊ಟ᪋タ࡟ᑐࡋ࡚ᡃࡀᅜึ࡜࡞ࡿ᪂⏕ඣ῝ᅾᛶ┿⳦ឤᰁ⑕ࡢㄪᰝࢆᐇ᪋ࡋゎᯒࢆ⾜ࡗࡓ㸦ㄪᰝ⤖ᯝㄽᩥⓎ⾲ in press㸧ࠋࡇࢀࡽࡼࡾᡃࡀᅜࡢ᪂⏕ඣ࡟࠾ࡅࡿ┿⳦⑕デ⒪ࡢၥ㢟Ⅼࡀᾋࡁ᙮ࡾ࡜࡞ࡾࡘࡘ࠶ࡿࠋ
Aspergillosis has been known as a most serious deep-seated mycosis. With the aging of the society, the increase of
COPD patients and the emergence of the antifungal resistance, the threat of the disease is expected to be even more
serious to our country. The aim of this project is to cope with the situation through the development of diagnostic ,therapeutic and preventic measures. We have started a collaborative study with Keio University on chronic pulmonary
aspergillosis in COPD patients to show a decline of pulmonary function in those sensitized with aspergillus. Moreover,by an analysis of the isolated fungi from patients, we found new significant findings such as novel resistant mechanism.
On the other hand, invasive fungal infection (IFI) is a life-threating infectious disease in high-risk neonates.
Strategies for the treatment and prevention of IFI in neonates in Japan remain unclear. Under this situation, we
conducted a nationwide retrospective survey to determine IFI incidence between January 2014 and October 2015
collaborate with the Japan Society for Neonatal Health and Development. During the study period, 23 proven or
probable IFI cases were reported. Estimated annual IFI incidence was 0.33/1000 live births of hospitalized neonates.
The mortality rate was 17.4%. This is the first report on the nationwide surveillance of neonatal IFI in Japan.
Continuous surveillance and treatment regimen for neonatal IFI are required to improve outcomes in high-risk
neonates in Japan.

ឤᰁ⑕◊✲㠉᪂࢖ࢽࢩ࢔ࢸ࢕ࣈ㸦-35,'(㸧Japanese Initiative for Progress of Research on Infectious Disease for Global Epidemic⑓ཎ┿⳦ Aspergillus fumigatus ࡢ⎔ቃ㐺ᛂ⬟ࡢᩘ⌮ࣔࢹࣝ໬࡟ࡼࡿ⌮ゎ࡜ࡑࢀ࡟ᇶ࡙ࡃឤᰁ㜵ᚚࢆ┠ᣦࡋࡓ◊✲⑓ཎ┿⳦ Aspergillus fumigatus ࡟ࡼࡿ࢔ࢫ࣌ࣝࢠࣝࢫ⑕ࡣඛ㐍ᅜࢆ୰ᚰ࡟ቑຍഴྥ࡟࠶ࡿࠋ᪤Ꮡࡢᢠ┿⳦⸆ࡢᢠ⳦ຊࡣ
༑ศ࡜ࡣゝ࠼ࡎᴟࡵ࡚㞴἞࡛࠶ࡿࡓࡵࠊ᪂つ἞⒪⸆㛤Ⓨࡀồࡵࡽࢀ࡚࠸ࡿࠋᡃࠎࡣࡇࢀࡲ࡛࡟ࠊ⮫ᗋศ㞳ᰴ࡜ḟୡ௦ࢩ࣮ࢣ
ࣥࢧ࣮㸦NGS㸧ᢏ⾡ࢆά⏝ࡋ࡚ࠊA. fumigatus ࡀឤᰁ୰࡟⸆๣⪏ᛶࡢࡳ࡞ࡽࡎࠊ㧗 ⪏ᛶ⬟ࢆ⋓ᚓࡍࡿ࡜࠸࠺⎔ቃ㐺ᛂ㐍໬࡜ࡶ࠸࠺࡭ࡁ⌧㇟ࢆ᫂ࡽ࠿࡟ࡋ࡚ࡁࡓࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⮬↛⎔ቃ୰࡛ࡢᙧ㉁ኚ໬ࢆࣔࢹࣝ໬ࡍࡿࡇ࡜࡛⑓ཎᛶࢆつᐃࡍࡿᙧ㉁ࡢྠᐃࢆ┠ᣦࡍࠋࠕ࡝ࡢࡼ࠺࡞ᙧ㉁ኚ໬ࡀ࡝ࡢࡼ࠺࡞⎔ቃᅉᏊ࡟ࡼࡗ࡚⏕ࡳฟࡉࢀࡿ࠿ࠖࢆ᫂ࡽ࠿࡟ࡋ࡚ࠊ⑓ཎᛶ
࡜⎔ቃᅉᏊࢆ⧅ࡆࡿࡇ࡜ࢆィ⏬ࡋ࡚࠸ࡿࠋ
Understanding of adaptation heterogeneity by mathematical modelling in pathogenic fungus Aspergillus fumigatus
Aspergillus fumigatus is a major cause of aspergillosis from allergic bronchopulmonary aspergillosis (ABPA) toinvasive pulmonary aspergillosis (IPA), particularly in immunocompromised individuals. The efficacy of antifungal
therapy is, however, incomplete, because of emergence of resistance strains worldwide. Besides, the molecularmechanisms of pathogenicity in A. fumigatus has yet to be fully elucidated. Of critical importance is further
understanding of the mechanisms behind infections with A. fumigatus. In this project, we propose the elucidation of thequantitative effect of environmental conditions on adaptation of A. fumigatus. Toward this goal, we explore thestatistical modelling framework to decipher the phenotypic heterogeneity of A. fumigatus. We utilize both clinicalisolates and strains obtained by experimental evolution to derive and validate the model, where phenotypic
heterogeneity can be explained by transcriptome data.

26༓ⴥ኱Ꮫࢢ࣮ࣟࣂࣝࣉ࣑ࣟࢿࣥࢺ◊✲ᇶᖿ࣮ࣜࢹ࢕ࣥࢢ◊✲⫱ᡂࣉࣟࢢ࣒ࣛ
Leading Research Promotion Program, Chiba University䇾㉸ಶయ䇿䛾⤫ྜⓗ⌮ゎ䛻ᇶ䛵䛟ḟୡ௦ᆺ䛂ឤᰁไᚚᏛ䛃◊✲᥎㐍ᣐⅬAdvanced Research of Infection and Immunity Based on Integrative Understanding of Host-Micobe
Interactionsᡃࠎࡢ㌟యࡣࠊከᵝ࡞⣽⬊࠿ࡽ࡞ࡿ㞟ྜయ࡜ࡋ࡚ᶵ⬟ࡋ࡚࠸ࡲࡍࡀࠊࡑࡇ࡟ࡣ✀ࠎࡢඹ⏕ᚤ⏕≀ࡀඹᏑࡋࠊࡑࢀࡽ࡜ࡢ┦஫స⏝ࢆ௓ࡋ࡚ಶయ࡜ࡋ࡚ᜏᖖᛶࢆ⥔ᣢࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡲࡍࠋᚑࡗ࡚ࠊᡃࠎࡢ೺ᗣࢆ⬣࠿ࡍឤᰁ⑕࡞࡝ࡢ
ࠕ⑌ᝈࠖ࡜ࡑࡢࠕ἞⒪ࠖࢆ⪃࠼ࡿ࠺࠼࡛ࠊᡃࠎࡢ͆ಶయ͇ࢆඹ⏕ᚤ⏕≀࡜ࡢ㞟ྜయࡍ࡞ࢃࡕ͆㉸ಶయ㸦6XSHURUJDQLVP㸧͇࡜ࡋ࡚ᤊ࠼ࡿࡇ࡜ࡀᚲせ࡛ࡍࠋࡑࡇ࡛ᖹᡂ  ᖺᗘ࠿ࡽࠊ┿⳦ࢭࣥࢱ࣮ᩍဨࡀ୰ᚰ࡜࡞ࡾࠊ་Ꮫ◊✲㝔ࠊ⸆Ꮫ◊✲㝔ࠊ㝃ᒓ⑓㝔ࡢᩍဨ࡜㐃ᦠࡋ࡚ࠊඹ⏕ᚤ⏕≀࡜ᐟ୺ච␿ࢩࢫࢸ࣒࡜ࡢ┦஫స⏝ࠊࡑࡇ࡬౵ධࡍࡿ⑓ཎయ࡟ࡼࡿᜏᖖᛶࡢ◚⥢࡜ឤᰁ⑕ࡢⓎ⑕ᶵᗎ࡞࡝࡟ࡘ࠸࡚ࡢᇶ♏◊✲ࢆࠊ⓶⭵࣭࿧྾ჾ࣭ᾘ໬ჾ࡞࡝ࡢྛ✀ჾᐁ࡛ࡢࣔࢹࣝᐇ㦂⣔ࢆ⏝࠸࡚ゎᯒࡋࠊࡑࡇ࠿ࡽᚓࡽ
ࢀࡿᡂᯝࢆ⤫ྜࡋ࡚⌮ゎࡍࡿ◊✲ᣐⅬࡢᙧᡂࢆ┠ᣦࡋࡓάືࢆ㛤ጞࡋࡲࡋࡓࠋࡇࡢάືࢆ㏻ࡌ࡚ࠊឤᰁ⑕࣭ච␿ไᚚ࣓࢝ࢽ
ࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿḟୡ௦ᆺࡢࠕឤᰁไᚚᏛࠖࢆ๰ฟࡋࠊᡃࠎࡢ೺ᗣ⥔ᣢ࡜ឤᰁ⑕࡞࡝ࡢඞ᭹࡬ࡘ࡞ࡀࡿ᪂つ࢖ࣀ࣮࣋ࢩࣙ
ࣥࡢ๰⏕ࢆ┠ᣦࡋࡲࡍࠋ
Infectious diseases caused by pathogenic microbes represent a major challenge to human health. Simultaneously, it is
known that human homeostasis is strictly regulated by the interaction between self-organs and trillions of resident
microorganisms. Therefore, in order to understand and overcome
life-threatening infectious diseases and related disorders, it isnecessary to recognize the human body as a “superorganism”, andelucidate host-microbe interactions from an integrative point ofview. For this project, we have organized a research group inwhich advanced studies of microorganisms, host immunity andinfectious diseases focusing on skin, respiratory and digestiveorgans, are being undertaken by researchers at the InohanaCampus of Chiba University. The research outcomes from thisintegrated project should enable the elucidation of host-microbe
interaction in mammals, and pave the way for innovation in thefield of infectious and immunological disorders.

27

ண⟬≧ἣ
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‫⛉ڦ‬Ꮫ◊✲㈝⿵ຓ㔠Grants-in-Aid for Scientific Research༊ࠉࠉศᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ ᖹᡂᖺᗘ 

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༢఩㸸༓෇Unit:thousand yen
28㐠Ⴀ
Administration ᙜࢭࣥࢱ࣮ࡢ㐠Ⴀࡣࠊᩍᤵ఍࡟┦ᙜࡍࡿ㺀ᩍဨ఍㆟㺁࡜ࠊᮏᏛࡢᩍᤵཬࡧᏛእࡢᏛ㆑⤒㦂⪅ࢆྵࡵࡓ㺀㐠Ⴀ༠㆟఍㺁࡟ࡼࡗ࡚⾜ࢃࢀࡿࠋMMRC management and decision are made by Faculty meeting and scientific council, composed of the internal
professors and external experts.
┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗≉௵ᩍᤵ➲ᕝ ༓ᑜ
MMRC,Director
Professor
Chihiro Sasakawa┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
ᩍᤵ
㸰ྡ
MMRC
Professor
ᩍဨ఍㆟ᵓᡂဨ
┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮෸ᩍᤵ㸵ྡMember of Faculty Meeting MMRC
Associate Prof.
ᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔ᩍᤵᯇỤ ᘯஅ
Graduate School of Medicine,Chiba University
Professor
Hiroyuki Matsue
ᮍ᮶་⒪⣔஦ົ㒊⟶⌮௻⏬ㄢㄢ㛗㸯ྡ
Administration Office for Future Medical Faculties and Research Centers
Directorᮾி་⛉኱Ꮫ
୺௵ᩍᤵᆤ஭ Ⰻ἞
Tokyo Medical University
Professor
Ryoji Tsuboi┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮㛗≉௵ᩍᤵ➲ᕝ ༓ᑜ
MMRC,Director
Professor
Chihiro Sasakawa┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
ᩍᤵ
㸰ྡ
MMRC
ProfessorᮏᏛ኱Ꮫ㝔་Ꮫ◊✲㝔ᩍᤵᯇỤ ᘯஅ
㐠Ⴀ༠㆟఍ጤဨ
Graduate School of Medicine,Chiba University
Professor
Hiroyuki Matsue
Member of Scientific Council ᮾ໭኱Ꮫ኱Ꮫ㝔㎰Ꮫ◊✲⛉ᩍᤵ஬࿡ ຾ஓ
Graduate School of Agricultural Science,Tohoku University
Professor
Katsuya Gomi៞᠕⩏ሿ኱Ꮫ⸆Ꮫ㒊ඹྠ◊✲ဨඵᮌ⃝ Ᏺṇ
Faculty of Pharmacy,Keio University
Senior Researcher MorimasaYagisawaᕝᓮᕷ೺ᗣᏳ඲◊✲ᡤᡤ㛗ᒸ㒊 ಙᙪ
Kawasaki City,Institute for Public HealthDirector
Nobuhiko Okabeᅜ❧ឤᰁ⑕◊✲ᡤ㒊㛗ᐑᓮ ⩏⥅
National Institute of Infectious Diseases
Director
Yoshitsugu Miyazaki⫋ဨᩘ (ᖖ໅⫋ဨ) Number of Staff Members
ᩍᤵ
෸ᩍᤵ
༊ศ

ᖹᡂ 29 ᖺ 9 ᭶⌧ᅾ
୍⯡⫋ဨ➼
ィ

ㅮᖌ

ຓᩍ

Iteam

Professors

Associate Profs.

Lecturers

Assistant Profs.

Researchers & staffs

Total⌧ဨ Present Number

2

7

0

3

6

18

ᮍ᮶་⒪⣔஦ົ㒊⟶⌮௻⏬ㄢ   Administration Office for Future Medical Faculties and Research Centers஦ົ㒊㛗Ⳣ㔝  ோDirector
Hitoshi Sugeno⟶⌮௻⏬ㄢ㛗㜿ᑿ Ᏺᕫ
Director
Misami Ao๪⟶⌮௻⏬ㄢ㛗㛗㇂ᕝ ṇ㞝
Deputy Head
Masao Hasegawa◊✲ᨭ᥼ಀ㛗⡿ඖ 㞝୍
Chief
Yuiti Yonemoto┿⳦ࢭࣥࢱ࣮ᨭ᥼ಀ
ಀ㛗
෌㞠⏝⫋ဨ
஦ົ⿵బဨ
29

MMRC Supportబ℩ ⣖Ꮚ㧗᲍ ṇ⏨
ᑠᕝ ♸㈗Ꮚ

Chief
Noriko Sase
Rehired staff㸦employee㸧 Masao Takanashi
Administrative AssistantYukiko Ogawa࢔ࢡࢭࢫ࣐ࢵࣉ
Location and Access Map/RFDWLRQRI &KLED8QLYHUVLW\&DPSXVAfter arriving at JR Chiba Station or Keisei Chiba Station, take buses bound for "Chiba University
Hospital" or "Minami-Yahagi" at bus station in east front exit 7 of JR Chiba Station, and get off at"Faculty of Pharmaceutical Sciences" or “Chuo-Hakubutsukan” bus stop. Approximately 15–30
minutes for both.

30

MMRC atInohanan

0DSRI005&LQ,QRKDQD&DPSXV&KXR+DNXEXWVXNDQ%XV6WRS

31

JR ༓ⴥ㥐ࠊிᡂ༓ⴥ㥐฿╔ᚋࠊJR ༓ⴥ㥐ᮾཱྀṇ㠃 7 ␒ࡢࣂࢫ஌ࡾሙ࠿ࡽࠕ༓ⴥ኱Ꮫ⑓㝔ࠖ⾜ࡁࡲࡓࡣࠕ༡▮సࠖ⾜ࡁࣂࢫ࡟஌㌴ࠊࠕ୰ኸ༤≀㤋࡛ࠖୗ㌴ࠊᚐṌ 1 ศࠋඹ࡟⣙ 15 ศࠋ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮
ࠛ260-8673 ༓ⴥ┴༓ⴥᕷ୰ኸ༊஻㰯 1 ୎┠ 8 ␒ 1 ྕ
TEL 043 (222) 7171 (௦⾲) FAX 043 (226) 2486
(࣮࣒࣮࣍࣌ࢪ: http://www.pf.chiba-u.ac.jp/ )32

Aspergillus fumigatus

Scopulariopsis brevicaulis

Exophiala dermatitidis

Schizophyllum commune

33

34

ᖹᡂ 29 ᖺ 10 ᭶Ⓨ⾜October 2017

Ⓨ⾜⪅ ༓ⴥ኱Ꮫ┿⳦་Ꮫ◊✲ࢭࣥࢱ࣮

Published by    ࢭࣥࢱ࣮㛗 ➲ᕝ ༓ᑜ

Chihiro Sasakawa, Ph.D.

   Director, Medical Mycology Research Centerࠛ260-8673

Chiba University༓ⴥ┴༓ⴥᕷ୰ኸ༊஻㰯 1 ୎┠ 8 ␒ 1 ྕ

1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan㟁ヰ 043-222-7171㸦௦⾲㸧

TEL: 81-43-222-7171

FAX 043-226-2486

FAX: 81-43-226-2486

༳ๅ ᰴᘧ఍♫ ṇᩥ♫
Printed by Seibunsha, Ltd. Chiba, Japan