Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

1P-001

Shikiho Takeuchi

Metabolism of flavonoid compounds by single nucleotide polymorphism mutants of human cytochrome P450 1A2

2P-002A

Shuki Yamazaki

Functional characterization of 31 CYP2B6 rare variants identified in 8,380 Japanese individuals

3P-003

Shimpei Watanabe

In vitro metabolic profiling of new synthetic cannabinoids, ADB-FUBIATA, AFUBIATA, CH-FUBIATA, and CH-PIATA

1P-004

Hisataka Itoh

In vitro inhibitory effects of acidic NSAIDs on human CYP4A11 activity: potent inhibition by sulindac sulfide

2P-005Shiori Takeji

Functional analysis of single nucleotide polymorphism in human cytochrome P450 2C19 expressed in E. coli

3P-006

Norio Masuda

Long-term survival of differentiated human intestinal organoids with higher CYP activities.

1P-007REI SATO

Comparison of contribution of alcohol dehydrogenase and P450s to aldehyde formation from abacavir in the human liver

2P-008

Yasuhiro Uno

Identification and characterization of tree shrew CYP2Cs

3P-009Miki Katoh

Effect of tyrosine kinase inhibitors used for treating renal cell carcinoma on CYP2J2 activity

1P-010A

WAKANA NAGAIThe effect of cryopreservation on the functions in human iPS cell-derived hepatic organoids

2P-011A

Genki Ushirozako

Identification and characterization of tree shrew CYP2Ds

3P-012

Norie Murayama

Cytochrome P450 2C21 and 2C41 Functionally Metabolize Warfarin and Omeprazole in Dogs

1P-013

KEIKO MAEKAWA

Kinetic deuterium isotope effects of deuterium-modified venlafaxine in cytochrome P450 oxidation reactions

2P-014

Yukiko Ueyama-Toba

Analysis of function in originally developed human liver organoids-derived hepatocytes"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

3P-015

Yuma Suzuki

Functional characterization of 20 rare variants of CYP2A6 by assessing coumarin 7-hydroxylation

1P-016

NGOC ANH NGUYEN

Production of a major human metabolite of rabeprazole, a proton pump inhibitor, by bacterial P450 enzymes

2P-017A

Yuichiro Iwai

Development of in vitro and in vivo evaluation systems for vitamin D derivatives with potent anti-proliferative activity

3P-018Frank Scheffler

The One Stop Metabolite Shop: Employing Multiple Tools To Solve Challenging Metabolite Projects

1P-019A

Yoo-Bin Lee

Functional Outcome of P450 2C8 Polymorphisms *15, *16, *17, and *18 Alleles

2P-020Chang Seon Ryu

In vitro metabolite identification study on SARS-CoV-2 Plpro inhibitors GRL0617 and HY-17542

3P-021

Yoshihiro Morishima

Hsp70 is required for the Hsp90-mediated insertion of heme into the heme-deficient apo-neuronal NO synthase P450

1P-022A

Kaitlyn Varela

Conversion of Artemisinin to Its Enzymatic Products by Cytochromes P450 3A4 and 2B6

2P-023A

Naoto Nakaya

Functional analysis of CYP3A4 variant (I301T) causing type 3 rickets

3P-024Chun-Zhi Ai

Prediction of the site forming reactive intermediate of therapeutic agents metabolized by cytochrome P450 3A4

1P-025A

Changmin Kim

Co-expression of Human Cytochrome P450 11A1, Adrenodoxin and Adrenodoxin Reductase

2P-026A

Eunseo Jeong

Characterization of Cytochrome P450 107P2 Enzyme from Streptomyces avermitilis

3P-027

Chun-Zhi Ai

Computational prediction of cytochrome P450-mediated bioactivation

1P-028

Kiyotaka Suzuki

Cytochrome P450 (CYP) 3A4 in metabolism of carbamazepine and erythromycin"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-029Eiichi Mizohata

X-ray crystallography of sesamin biosynthetic CYP81Q proteins

3P-030Taro Tamada

Approach to Complementary Use of Neutron and X-ray Crystallography for Cytochrome P450

1P-031

Aya Okuda

Analysis of solution structure of CYP105A1 with small angle X-ray scattering

2P-032A

Svetlana Gorina

Alterations of catalytic mechanisms of atypical cytochromes P450 of the CYP74 clan

3P-033

Yoshino Kojima

X-ray crystal structure analysis of CYP85A3, a key enzyme to produce highly potent brassinosteroids

1P-034A

Yana Toporkova

Hydroperoxide bicyclases – new enzymes of brown algae oxylipin biosynthesis

2P-035SAYURI MOTOTANI

Synthesis and preliminary biological evaluation of 23,23-difluorovitamin D 3 analogues

3P-036CHISATO TAKAHASHI

Impact of Substrate Deuteration on Warfarin Metabolism Involving CYP2C9

1P-037A

Megumi Ishigami

Rational Development of New Structural Decoy Molecules Which Respond to Cytochrome P450BM3

2P-038A

Mahiro Nakazawa

Introduction of various metal ions into cytochrome P450 using ferrochelatase co-expression system

3P-039Yasuhiro Tateishi

Mechanism of oxidative carbon-carbon bond cleavage by cytochrome P450 2B4

1P-040A

Yongwei Zhao

Based Peptide cyclisation by cytochrome P450: A case study of unexpected events in the biarylitide family

2P-041A

NGOC TAN CAO

Hydroxylation of branched alkanes by cytochrome P450 enzymes

3P-042

Shinya Ariyasu

Catalytic Oxidation of Gaseous Alkanes by Wild-type Cytochrome P450BM3 with Chemically Evolved Decoy Molecules"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

1P-043A

Elena Smirnova

The CYP74 clan cytochromes P450 in the lancelets (Branchiostoma floridae, B. belcheri, B. lanceolatum)

2P-044A

Alicia Kirk

Understanding the mechanism of CYP199A4 catalyzed aliphatic dehydrogenation: an ONIOM(B3LYP:AMBER) study

3P-045

Vandana Kardam

Computations Reveal a Crucial Role of F121 and F363 Aromatic Dyad in the Catalytic Function of CYP71D of Mint Superfamily

1P-046A

Stephen G. BellThe rational design of heme enzyme biocatalysts

2P-047A

Tu Minh Ho

Exploration of the Conversion of Chenodeoxycholic Acid to Cholic Acid by Human Cytochrome P450 8B1 through the Synthesis of
deuterated substrate isotopologues

3P-048Jinzen Ikebe

Computational prediction of P450 variants to improve production rates of target products using MSPER

1P-049Yasuhiro Mie

Electrochemically-driven P450 reactions to produce pharmaceutical hydroxyvitamin D 3

2P-050A

Cancelled

3P-051

Makoto Kataoka

Development of a novel safe booster with antedrug characteristics to improve oral bioavailability of CYP3A Substrates

1P-052A

Yuya Yokoyama

Directed evolution of P450BM3 for the expansion of the structural diversity of decoy molecules

2P-053A

Kanta Kuribayashi

Detection of interactions between cytochrome P450 and redox proteins using a Metallosphaera sedula scaffold protein

3P-054

Sachiyo Yoneda

Production of drug metabolites using Actinomycete cytochrome P450

1P-055A

Yichi Zhang

Engineering and encapsulating a thermostable P450 fatty acid ω-hydroxylase for the sustainable production of biopolymers

2P-056A

Cancelled"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

3P-057

Zhiqi Cong

Reinforcing Peroxygenase Activity of P450s by Engineering Hydrogen Peroxide Tunnels

1P-058A

Ya Fen Yong

Engineering of Cytochrome P450 for Synthesis of Novel Reveromycin Derivatives

2P-059A

Jeong-Hoon KIM

Production of new terpene derivatives usning engineered CYP102A1 enzymes

3P-060Loïc Bourdon

Characterization of ancestral Cytochrome P450 encapsulated in virus-like particles as nano-scale bioreactors

1P-061A

Jamie Lynch

Evolution of P450BM3 (CYP102A1) for vitamin metabolism

2P-062A

Victoria Barros Metlova

Drug Fragment Diversification via P450-catalysed C–H Activation

3P-063

John C Hackett

Fluorescence quenching in dark CYP19A1 nanodiscs suggests the presence of more than one binding site in human CYP19A1.

1P-064A

Nirupama Sumangala Korada

Exploring the influence of cholesterol on the catalytic activity of steroidogenic human aromatase (P450 19A1)

2P-065A

Neikelyn Burgos-Tirado

Mutagenesis studies targeting a second steroid-binding site in human P450 17A1 (steroid 17-hydroxylase/17,20-lyase)

3P-066

Cancelled

1P-067A

MENGLU LI

Visualizing cytochrome P450 in living hepatocytes by Raman imaging

2P-068A

Fumiya Ito

Non-Recombinant Whole-Cell Biocatalysts Controlled with Dummy Substrates for Degradation of Soil Contaminants

3P-069Erisa Harada

Sesamin oxidizing enzyme CYP92B14 regulates lignan accumulation in sesame seeds

1P-070AMIZUKI NISHIMURA

Application of fungal cytochrome P450 monooxygenases for production of alpha-santalene derivatives.

"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

2P-071A

masato homma

The elucidation of the biosynthesis of canonical strigolactones mediated by CYP722C

3P-072

Yoshimi Yamamura

A novel C-12 oxidase, CYP76AH93, is involved in abietane-type diterpene biosynthesis in Isodon japonicus

1P-073A

CHEN CHEN

Identification of cytochrome P450 monooxygenases involved in fungal metabolism of sesquiterpene alcohols

2P-074A

Alix Charles Harlington

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

3P-075

Takuya Yamaguchi

Discovery of CYP94A and CYP77A fatty acid hydroxylases that metabolize aldoxime in floral nitro and nitrile compounds biosynthesis
in loquat

1P-076A

Goossens A.

Glycosylated triterpenoids from Saponaria officinalis as endosomal escape enhancers: pathway discovery and perspectives ofmetabolic engineering

2P-077A

Duck-Hyun Kim

The repertories and molecular evolution of the cytochrome P450 (CYP) superfamily in metazoans

3P-078

Takatoshi Wakabayashi

Cytochrome P450-catalyzed biosynthesis of strigol, a strigolactone produced by cotton

1P-079A

Peter Giang

CYP108N12: Monoterpene biodegradation to biocatalytic oxidations.

2P-080Shin-ichi Ozaki

Heme transport and metabolism in Y. pseudotuberculosis

3P-081J

Naoki Takaoka

Metabolism of aldehyde odorants by nasal aldehyde-metabolizing enzymes and their inhibition by drugs

1P-082

Tomoya Hino

Structural and functional analysis of the substrate uptake pathway of alkane hydroxylase AlkB

2P-083

Hae Chan Jeong

Enzymatic production of 3-hydroxyphloretin using tyrosinase derived from Bacillus megaterium

3P-084

Yu-jin Lee

Functional Characterization of Unspecific Peroxygenase from Fungus Daldinia species"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

1P-085

Kota Yoshioka

Functional alteration of 2-oxoglutarate-dependent dixoxygenases that are involved in oxidative degradation of tomatine

2P-086

Ryosuke Negoro

Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using genome-editing technology.

3P-087

Daisuke Takani

Synthesis and biological activation of diester-type indomethacin prodrugs considering the substrate specificity of humancarboxylesterase isozymes

1P-088Kazuya Shimomura

Aldo-keto reductase 1A1 functions as a drug-metabolizing oxidase that forms aldehydes from alcohols: a study mainly using 4hydroxytolbutamide

2P-089J

Yoshiyuki Sakai

Role of hepatic arylacetamide deacetylase in cholesterol/bile acid homeostasis

3P-090Sango Nakashima

Identification of novel two reactive metabolites formed from trametinib by AADAC and CYP3A4 in the human liver

1P-091

Makiko Shimizu

Evaluation and confirmation for rare but impaired variants of human flavin-containing monooxygenase 3 found in an updated
database of a Japanese cohort

2P-092JSHOTARO UEHARA

Metabolism and renal toxicity of SGX523 in chimeric mice with humanized liver

3P-093J

Shuji Takeuchi

Regulation of human hepatic UGT1A6 expression by A-to-I RNA editing

1P-094

Takumi Ohno

Expression and induction of human UGT isoforms in liver and small intestine of UGT1/2 humanized mice

2P-095A

Madoka Masuzumi

Met116 of UDP-Glucuronosyltransferase 2B7 (UGT2B7) determines substrate specificity toward morphine

3P-096

Yuu Miyauchi

Detection of UDP-glucuronosyltransferase in several oligomeric forms by immunoblotting and prediction of oligomer-forming sites
with deletion mutants

1P-097A

Hinako Seto

Identification of UDP-glucuronosyltransferase 2b1 (mUgt2b1) as the main enzyme involved in glucocorticoid glucuronidation in mice:evidence from Ugt2b1-knockout mice

2P-098Chun-Zhi Ai

Identify UDP-glucuronosyltransferase1A1 substrates or inhibitors from natural products by pharmacophore and machine learningmodels"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

3P-099Hiroaki Shimada

The interaction between cytochrome P450 inhibitors and eicosanoid production in rat liver

1P-100A

Juan Valentin-Goyco

Mechanism of 18-hydroxylase activity modulation by 320 residues in human Cytochrome P450 11B1 and 11B2

2P-101A

Kevin D. McCarty

3P-102

Yuchen Liu

Metabolism of 8,9-unsaturated sterols by human CYP27A1 and CYP11A1

1P-103A

Jibira Yakubu

Curcumin and metformin nano formulations for inhibition of CYP17A1 activities

2P-104

Dave Arthur Robledo

Transactivation potencies of estrogen receptor ɑlpha (ERɑ) by DDTs: Interspecies comparison of the killer whale, Baikal seal, andmouse using in vitro and in silico approaches

3P-105Chao Zhang

Role of the redox partner and the acid-alcohol pair in the complex regulation of human aromatase activity

1P-106A

Katyayani Sharma

Endocrine Disrupting Chemicals as “structural cues” for inhibition of CYP17A1

2P-107

Saki Gotoh-Saito

Genome-wide profiling of enhancer RNA initiation events identified novel drug-responsive enhancers in human hepatocytes

3P-108

Daisuke Aibara

Transcriptional regulation of the Osbpl3 gene by PPARγ in the fatty liver disease

1P-109Jun Terashima

Expression pattern of drug-metabolizing enzymes in 3D spheroid of lung cancer cells, A549 that have acquired irinotecan resistance

2P-110Genki Minegishi

Different regulation of cytochrome P450 3a in liver and small intestine by cholesterol and cholic acid feeding in mice

3P-111

Seiya TakemotoRole of DNA G-quadruplexes in the ABCB1 gene to regulate MDR1 expression in cancer cells and control the sensitivity to paclitaxel

1P-112

Takuomi Hosaka

Rosiglitazone synergistically induces CYP3A4 in human intestine-derived LS180 cells through activation of nuclear receptors PPARγ and
PXR"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-113A

Albert Braeuning

Proteomics Reveal In Vivo Effects of Phenobarbital in Mice with Humanized Livers

3P-114

Damjana Rozman

Deletion of CYP51A1 and other cholesterol synthesis genes alters gene regulatory networks and affects drug metabolism pathways inhuman hepatocytes

1P-115

Magdalena, Katarzyna Urbaniak

Toward production of safe food – how to control the bioaccumulation of selected Persistent Organic Pollutants in cucurbits

2P-116A

Qi Zhang

Down-regulation of Cyp2e1, Cyp4al0 and Cyp4a14 alleviates alcoholic liver injury by reducing oxidative stress

3P-117

Tatsuya Sueyoshi

Ligand induced GR heterodimerization with MR and P450 gene regulation

1P-118

Taiji Miyake

Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver
chimeric mice

2P-119Hiroki Sunakawa

Evaluation of P-gp-mediated drug-endogenous substrate interactions

3P-120Liyanage Manosika
Buddhini Perera

Clinical analysis and in vitro correlation of BCRP-mediated drug-drug interactions during absorption phase

1P-121

Tokio Morita

Membrane permeation variation by pharmaceutical excipient using PAMPA

2P-122

Mizuho Urabe

Evaluation of HepaRG cells as an in vitro tool for assessment of clinical induction risk of CYP3A4

3P-123

Yasuhiro Masubuchi

Inhibition of CYP2D6 and CYP3A4 associated with metabolic intermediate complex formation by piperine, a black pepper component

1P-124

Rika Ishikawa

Comprehensive evaluation of cyclic cell-penetrating peptides on inhibition potency of P-gp, BCRP, OATP1B1, and OATP1B3 in vitro
and its relation to physicochemical properties

2P-125

Teruki Hamada

Predictability of hepatic metabolism-mediated drug-drug interaction (DDI) in clinical with use of PXB mice

3P-126

Shun Hayashi

Identification of enzymes involved in the metabolism of tipepidine and prolongation of the half-life of tipepidine by combination use
with an enzyme inhibitor"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

1P-127A

Yusuke Kamiya

A Case of Multiple Drug-Drug Interaction for Anticoagulant Effect of Warfarin

2P-128NATSUMI HASHIMOTO

Significance of choice of substrate drugs and buffer conditions which affect the assessment of in vitro inhibition of metabolism by
CYP3A

3P-129

Ryo Tamura

Quantitative analysis of the effect of absorption characteristics on intestinal P-gp-mediated drug-drug interactions

1P-130

Hana Kumemura

A new approach to evaluate in vivo inhibition ratio of CYP3A based on data from adverse event reporting system without using
pharmacokinetic information

2P-131

Ikumi Washio

DDI risk assessment for OATP in drug development; time-dependent inhibition assay

3P-132

Toshiyuki Kudo

Estimation of contribution of CYP3A4 and aldehyde oxidase in flunitrazepam metabolism using cryopreserved human hepatocytes

1P-133Cancelled

2P-134

KOZO TAGAWA

Development of Dissolution Evaluation System for Drug Absorption (IV): Additional Oral Administration Module of In Vitro 3D Gastric
Emptying Model for Orally Disintegrating Tablet

3P-135

Kenta Mizoi

The development of an evaluation system for drug excretion into bile using monolayers of human bile duct epithelial cell-likeorganoids

1P-136

Kotaro Shirai

Characterization of new human induced pluripotent stem cell-derived intestinal epithelial cells and their application to an integrated
small intestine liver device

2P-137

Keishi Yamasaki

Involvement of protein binding inhibition in dexmedetomidine concentration change in ECMO circuits during midazolam use

3P-138J

Hiroyuki Sato

Evaluation of receptor-mediated transcytosis using human iPS cell-derived brain microvascular endothelial-like cells

1P-139Jundai KOBAYASHI

Cellular uptake and permeability of silica particles with different size in placental cells

2P-140

Yuka Nakamura

Utility of AGP KO mice to assess the contribution of AGP in drug pharmacokinetics"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

3P-141

Yugo Yasugi

Effect of ingested water volume on gastric drug absorption and disposition in humans

1P-142shinichiro horiuchi

Functional evaluation of a co-culture model of organoid-derived intestinal epithelial cells and mesenchymal stromal cells for intestinal
drug absorption prediction

2P-143

Mitsuto Watanabe

Characterization of renal clearance among human, monkey, and mouse

3P-144J

Takashi Kitaguchi

Improvement of predictability of human oral absorption of glycoside compounds by modified culture method of human iPS cellderived small intestinal epithelial cells

1P-145

Ryo Sakamoto

Effect of species differences in expression of placental MATE1 on fetal transfer of organic cations

2P-146

Takumi Tanaka

Assessment of biomarkers for SOX chemotherapy dosing in CKD model rats

3P-147

Kai Tanaka

Development of human intestinal organoid-derived monolayer model for drug absorption study

1P-148Masakazu Shibata

Prediction of Human Pharmacokinetic Profiles of the Antituberculosis Drug Delamanid from Nonclinical Data: Potential Therapeutic
Value against Extrapulmonary Tuberculosis

2P-149

Ning Ding

Utility of marmoset for the prediction of human pharmacokinetic profiles of antisense oligonucleotides after intravenous drug
administration

3P-150

Hiroki Takezaki

Optimization of culture conditions to form a tight monolayer of intestinal epithelial cells at the duodenum, jejunum, and ileum in dogs

1P-151

Hiroyuki Kusuhara

Directional transport across a tight monolayer of intestinal epithelial cells at the ileum in dogs.

2P-152Chien-Chang Shen

PXB-mice with humanized livers provide better predictions of human pharmacokinetics compared to CB17-SCID mice

3P-153

Evita Van de Steeg

OPTIMIZED NORMOTHERMIC MACHINE PERFUSION OF LIVER AND KIDNEY USED TO PREDICT HUMAN PHARMACOKINETICS

1P-154

Evita Van de Steeg

INTESTINAL TISSUE ORGANOIDS TO STUDY DRUG TRANSPORT AND METABOLISM FROM INFANTS TO ADULTS"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-155J

Yoshihide Yamanashi

Hepatic NPC1L1 exacerbates NAFLD by suppressing biliary excretion of oxysterols

3P-156

ASAMI Saito

Appropriate in vitro tool for the assessment of MATE-mediated DDI.

1P-157

Gaku Ogiwara

Identification of vincristine uptake transporter by CRISPR/Cas9 system

2P-158Qiunan Zhu

Molecular identification of specific binding site of dotinurad to uric acid transporter URAT1 responsible for its selective uric acidreuptake inhibition

3P-159Ryo Sugimoto

Organ protective effect of SGLT2 inhibitors by maintaining normal Na+-influx associated with D-glucose transport

1P-160

Kazuki Fujita

Potentiation of Uricosuric Effect of Dotinurad by Trans -Inhibition of Uric Acid Reabsorptive Transporter URAT1

2P-161A

Rikako Imamura

Functional analysis of the organic anion transporter NPT4 by metabolomics approach

3P-162

Yuya Nakazono

Evaluation of drug-induced cholestasis involving drug metabolism using a novel in vitro cultured hepatocyte system icHep

1P-163

Saki Noguchi

Uptake of methylmalonic acid by proximal tubular transporters

2P-164J

Tomoya Akashi

Mechanism of inhibition and transport of human SGLT2–MAP17 glucose transporter

3P-165Shin-ichi AKANUMA

Functional change in P-glycoprotein at the inner blood-retinal barrier, formed by retinal capillaries, in diabetic models in vivo

1P-166

Mizuki Seki

Role of MFSD2A in transplacental lysophosphatidylcholine-docosahexaenoic acid transfer in mouse placenta

2P-167

Martha Larasati

Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: a new concept

3P-168

Gakuto Maeyama

Regulation of hepatic BSEP expression by A-to-I RNA editing enzymes"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

1P-169WANGYANG LIU

The expression of scaffold proteins and efflux transporters in HCC827 lung cancer cells after EMT/MET inducement

2P-170

Ryuto Tomabechi

Exploring chemical structures required for the inhibition of SLC46A3 transport function

3P-171

Kentaro Yano

Contribution of therapeutic agent-induced alterations in efflux transporters’ expression and function to drug resistance in follicularlymphoma.

1P-172

Sakura Mama

Determination of transporter mRNA levels in the isolated polysomes of human blood-brain barrier endothelial cells

2P-173

Keiichi Yotsumoto

Prediction of human hepatic clearance for highly protein-bound OATP substrates: a case for DS-2330b

3P-174Mamoru Tanaka

Analysis of the role of drug transporters in cellular accumulation of bendamustine using the RPTEC/TERT1 and HK-2 human renal
proximal tubular epithelial cell lines

1P-175

Yoshinobu Nakamura

Do hypotonicity and accessory proteins required for Maxi-Cl channel affect SLCO2A1-mediated prostaglandin E 2 transport activity?

2P-176

Eisuke Nakano

Reuptake mechanisms of human placental trophoblast cells-derived extracellular vesicles in the placental trophoblast cells

3P-177J

Hiroaki Yata

Glucose transporter-mediated transport of newly synthesized creatine analog in human blood-brain barrier endothelial cells

1P-178

Toshiki Shimizu

Differential enhancement effects of non-equilibrium atmospheric pressure plasma irradiation on membrane transport in humanderived cells

2P-179Kim Nguyet Nguyen

Role of BCRP/ABCG2 in pharmacokinetics and neurotoxicity after intrathecal administration of methotrexate in mice

3P-180J

Haruka Morimoto

Functional identification of ATP13A4 as a plasma membrane polyamine transporter: analysis of the spermidine transport function

1P-181

Kaito Matsui

Analysis of the transport function of SLC19A2/3 for amiloride: utilization as a fluorescent probe substrate

2P-182Kei Higuchi

Regulation of localization and function of MCT7 by ancillary proteins CD147 and GP70

"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

3P-183Misato KUNIEDA

Methotrexate resistance by Slc16a6/MCT7 in cancer cells

1P-184Mai Hirose

Comparative evaluation of the choline transport functions of novel choline transporters and choline transporter 1

2P-185

Shotaro Yoshino

Investigation of the role of human hepatic BCRP by using adeno-associated virus mediated gene delivery

3P-186

Ruth Shekina Lumumba

Involvement of BCRP and other efflux transporters in pharmacokinetics of pazopanib in mice

1P-187

Naoki Saito

Impact of genetic polymorphisms in SLC46A3 on the transport function and efficacy of trastuzumab emtansine

2P-188

Koki Sugiyama

Substrate specificity of monocarboxylate transporter 6 (MCT6)

3P-189Yui Ikeda

Regulation of drug-metabolizing enzymes activity by ABCC4 expression in liver

1P-190A

Xiaomei Fan

Association of ABCB1 polymorphism with therapeutic response to valproic acid in pediatric patients with epilepsy

2P-191

Melody Nokhutula Shumba

Effect of Cigarette smoking and LPS on SLCO2A1 expression

3P-192

Johannes A. Sake

Knockout of BCRP in NCI-H441 cells to create a more physiologically-relevant in vitro model of human distal lung epithelial barrier

1P-193

Sunhapas Soodvilai

Ivermectin reduces MDCK cyst growth in autosomal dominant polycystic kidney disease

2P-194

Promsuk Jutabha

The effect of depsidone derivatives on the reduction of tenofovir toxicity in organic anion transporter 1-expressed MDCK cells

3P-195

Rattiporn Boonnop

Interaction of Pinocembrin on Human Renal Organic Anion Transporter 1 and 3

1P-196

Tasuku Yokoyama

Impact of concomitant drugs on cilostazol pharmacokinetics in patients with cerebral infarction"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-197

Toshifumi Kimura

Favorable pharmacological effects of FF-10850, a liposomal topotecan, could be explained by quantitative analysis of unencapsulated
drug exposure in target tissues

3P-198

Shugo Yamashita

Evaluation of active-targeting polymeric micelle function by gamma distributed delay compartmental analysis using a tissue-isolated
tumor perfusion system

1P-199

Shoko Nomura

Improvement of delivery and anticancer effects of liposomal irinotecan on stroma-rich tumors by co-administration of Salmonella
Typhimurium VNP20009

2P-200RYOTA TSUDA

Investigation of delivery of immune checkpoint inhibitors after i.p. administration to peritoneal metastasis via direct penetration:
Effect on differences in type of cancers

3P-201

Hisanao KISHIMOTO

Inhibition of mucin-type glycosyltransferase enhances membrane permeation of lipophilic anticancer drugs

1P-202

Takayuki oguma

Effects of in vivo distribution kinetics and intrapancreatic islet distribution of Lipid nanoparticles by their phospholipid components
and particle size

2P-203A

Yuta Watanabe

Treatment of hepatocytes with palmitic acid induces the release of extracellular vesicles with tropism to activated hepatic stellate
cells

3P-204

Shoichiro Fukuda

The molecular weight limitation on increased intestinal absorption by ionic liquids

1P-205A

Shinya Hirata

Multi-functionalized liposomes optimized with functional lipids improve the efficiency of intracellular protein delivery

2P-206J

Mariko Kamiya

Development of local expression mRNA-loaded lipid nanoparticles based on a modification of novel peptide lipids

3P-207

Takeshi Hori

Nuclear receptor CAR requires GADD45B to mediate liver tumor promotion by phenobarbital in mice

1P-208

Takeshi Susukida

Glycolysis in CD8+ T cells plays a major role in the onset of HLA-mediated idiosyncratic drug toxicity

2P-209J

Hiroshi Arakawa

Utility of high content analysis of drug-induced kidney injury using 3D-cultured kidney epithelial cells

3P-210

Kosuke Nagasaka

Risk Assessment of Reactive Metabolites in Drug Discovery: Comparative Analysis of Cysteine and dGSH Trapping Assays"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

1P-211

Shigeki Aoki

The importance of HLA polymorphism-dependent endoplasmic reticulum stress in abacavir-induced hypersensitivity reactions

2P-212Junya Nagai

Effects of prostanoid EP receptor agonists on HIF activation in human kidney epithelial cell line HK-2

3P-213Kazuma Hamada

Proteomic analysis of mitochondria to elucidate the immune-mediated drug-induced liver injury in NAFLD

1P-214

Yasuhito Tsukushi

Preventive effect of omeprazole as drug repositioning strategy on onset of OIPN

2P-215A

Yu Harakawa

Development of a read-across method for evaluating repeated-dose toxicity using molecular descriptors and rat cytochrome P450
inhibition test data

3P-216J

Yoshiki Hashimoto

Development of serotonin release assay with human jejunal spheroid-derived enterochromaffin cells and risk evaluation of emesis
induced by ALK/ROS1 tyrosine kinase inhibitors

1P-217A

MING YUAN

Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces prolactin in male offspring at the neonatal stage: a possible
influence on sexual immaturity

2P-218A

Shunsuke Azuma

Identification of bacterial proteins binding to perfluorooctanoic acid3P-219Kazuki Takeda

Environmentally harmful paper recycling? sensitizer compounds in paper recycling effluent, exerts dioxin-like effects on zebrafish(Danio rerio ) via aryl hydrocarbon receptors

1P-220A

Takumi IWASAKA

Establishment of a new and easy-to-construct liver injury mouse model by drinking-water administration

2P-221A

Qiyue Zhang

CREB is a potential marker associated with drug-induced liver injury: the development of the robust reporter stable HepG2 cell lines

3P-222

Takumi Sato

Establishment of a screening system to evaluate direct and indirect rat CAR activators

1P-223A

Jorge Carlos Pineda Garcia

Characterization of behavioral effects evoked by synthetic cannabinoids cumyl-pegaclone and 5F-cumyl-pegaclone: a dose and timeframe study

2P-224

Toshiaki Tsuchitani

Analysis of nonlinear pharmacokinetics of telmisartan using physiologically-based pharmacokinetics model incorporating targetmediated drug disposition (TMDD-PBPK model)"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

3P-225

RIKA NISHIYAMA

Physiologically Based Pharmacokinetic (PBPK) Model in Mice for Predicting Human Dose of the Therapeutic Drug for
Trimethylaminuria (TMAU)

1P-226

Ryo Nakamura

Comprehensive analyses of DPP-4-mediated linagliptin nonlinear pharmacokinetics in human and rodents by PBPK modelingcombined with a cluster Gauss-Newton method

2P-227yuto tanaka

Construction of PBPK model describing autoinduction of Cyp1as after oral administration of TSU-68 in rats

3P-228

Toshimichi Nakamura

Top-Down Extended Modeling of the Physiologically-Based Pharmacokinetics (PBPK) of Levonorgestrel in Obesity

1P-229Mengyang Yu

Population Pharmacokinetics of Ilaprazole in Patients with duodenal ulcer and Healthy Individuals in Chinese

2P-230Kai Obuchi

Functional Characterization of Seven Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil
Treatment-Related Toxicity

3P-231

Sayana Matsuda

Pharmacogenomic analysis of risk factors for bleeding events in Japanese patients with atrial fibrillation treated with apixaban

1P-232AKIRA KUBOTA

In vivo and in silico assessment of estrogenic potency of endocrine disrupting chemicals using zebrafish (Danio rerio )2P-233

Reiya Yamashita

Phosphorylation of neurotrophin receptor TrkB in serum extracellular vesicles as potential biomarker of food component
ergothioneine-induced cognitive enhancement in humans

3P-234

Amit V Pandey

Genetic variations in cytochrome P450 reductase (POR) as biomarkers for steroid and drug metabolism

1P-235A

Nontaya Nakkam

Genetic polymorphisms of CYP2C9 and HLA genes associated with severe cutaneous adverse reactions induced by phenytoin

2P-236A

Xiaomei Fan

SCN1A polymorphisms and haplotypes are associated with valproic acid treatment outcomes in Chinese children with epilepsy

3P-237Jong-Min Kim

Effects of CYP3A5 and SLCO1B1 Polymorphisms on the Pharmacokinetics of Atorvastatin and 2-Hydroxy Atorvastatin in Humans

1P-238

Ryuto Isogai

In vitro human immortalized cell-based blood-brain barrier models are useful for evaluation of brain permeability of AAV vectors"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

演題名
Presentation title

筆頭著者
First name author

2P-239J

Seiya Ohki

Human immortalized cell-based blood-brain barrier spheroid models offer an applicability assessment tool in characterizing the brain
permeability of cyclic peptides

3P-240

Sayaka Deguchi

Generation of liver-on-a-chip for cholestasis research

1P-241

Fuki Yokoi

Elucidation of inflammatory bowel disease pathophysiology using human iPS cell-derived colonic epithelial cells

2P-242J

Erika Kojima

Usability of human primary cell-based 3D intestine model for predicting human intestinal availability

3P-243MISA HOSHI

Application of gut microphysiological system to predict intestinal absorption of small molecule drugs

1P-244

Takeo Shimasaki

Development of a Multi-Connectable Micro Physiological Systems Enabling Pharmacokinetic Analysis

2P-245

Evita Van de Steeg

NEXT LEVEL DRUG RESEARCH IN AN EX VIVO TISSUE GUT-ON-A-CHIP MODEL: ADVANCED APPLICATIONS OF THE INTESTINAL EXPLANTBARRIER CHIP

3P-246Rodi ABDALKADER

The development of a micro physiological system of the human corneal epithelium under dry eye-like conditions

1P-247

Yuchen Sun

Analytical method development and validation for nucleic acid biomarkers as a drug development tool: points to consider

2P-248J

Tenyu Ando

Role of CYP enzymes in the expression of chemical-induced skin sensitization parameters in human HaCaT and THP-1 cells

3P-249Hiroki Onoda

Univasal Alignment Method and Heme Placement Method for Predicted Structures of Cytochrome P450

1P-250

Yuki Doi

In-Silico Prediction of Plasma Concentration-Time Profiles in Rodents Using Deep Neural Networks and its Application to Drug
Discovery

2P-251

Reiko WATANABE

Investigation of methods for constructing prediction models for CYP inhibition using deep learning

3P-252J

Yohei Kosugi

Ensemble Machine Learning Approaches based on Molecular Descriptors and Graph Convolutional Networks for Predicting the Efflux
Activities of MDR1 and BCRP Transporters"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

1P-253

Katsuhisa Morita

Investigation of factors contributing to the estimation accuracy of deconvolution toward application to large-scale toxicogenomics
databases

2P-254A

Shoma Ito

Comprehensive Clinical Risk Assessment of Drug Candidate Compounds using ADMET-AI Models

3P-255

Takahito KUMAGAWA

In vitro and in silico assessment and predictive modeling of transactivation potencies of dog and cat estrogen receptor alpha byenvironmental chemicals

1P-256A

Tamana Enami

Development of a model for predicting a chemical-induced CYP inhibitory activity using images data showing chemical structure
information

2P-257

Tadahaya Mizuno

Investigation of the learning process of diverse chemical structures by chemical language models for toxicity prediction

3P-258Masatomo Takahashi

Development of a 96-well plate sample preparation method for the assessment of drug-induced liver injury by multi-omics analysis
based on mass spectrometry

1P-259A

kosuke Hata

Development of a semi-automated preprocessing system for single-cell proteome/metabolome analysis and its application to drug
hepatotoxicity assessment

2P-260A

Maria Natalia Rojas Velazquez

Exploring Novel Variants of the Cytochrome P450 Oxidoreductase Gene from the Genome Aggregation Database: Integrating
Bioinformatics Tools and Functional Assays

3P-261

Hannah Nicole Wilkins

Identifying antiretroviral drug metabolism and transport potential in blood brain barrier-resident cells

1P-262

Damjana Rozman

Unraveling potential biomarkers of metabolism associated liver disease and hepatocellular carcinoma

2P-263Jae-Seong Lee

The genome of the marine monogonont rotifer Brachionus plicatilis : Genome-wide expression profiles of 28 cytochrome P450 genes
in response to chlorpyrifos and 2-ethyl-phenanthrene

3P-264J

Siyu Liu

Establishment of a workflow for spatial pharmacokinetics analysis using three-dimensional microscopic imaging data

1P-265

Tomoko Yokoyama

The development of a high-throughput fully automated 384-well microplate Ligand Binding Assay system

2P-266

Tomoshige Ando

Development of analytical method for drug metabolite identification using "UPLC x IMS" separation and high-resolution mass
spectrometry"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

3P-267

Noritaka Hashii

Subunit DAR distribution analysis of ADC in human plasma by affinity purification and intact mass spectrometry

1P-268

Takeshi Tajima

Cellular kinetics and pharmacodynamics of tisagenlecleucel for CAR-T cell immunotherapy in patients with relapsed or refractory
follicular lymphoma

2P-269

Yoichi Naritomi

Pharmacokinetics and anti-tumor effects of HLCN061, iPS cell-derived gene-edited NK cells

3P-270Akihiro Matsumoto

Development of quantitative digital PCR methodology with a tissue weight-based unit for the biodistribution evaluation ofrecombinant adeno-associated virus

1P-271

Manami Tada

Considerations and approaches for evaluation of protein binding of oligonucleotides

2P-272J

Miki Yokoyama

A quantitative human pharmacokinetics prediction method for Fc-fusion proteins

3P-273

MASAYA SHIMADA

Current status and future perspective of DMPK research for Targeted Protein Degrader

1P-274

Naomi Tamura

Survey and Consideration for Evaluation of Tissue Distribution and Plasma/Serum Protein Binding of Approved Oligonucleotide
Therapeutics

2P-275

Yasufumi Fukano

Questionnaire survey results on nonclinical pharmacokinetic evaluation of oligonucleotide therapeutics in pharmaceutical companies

3P-276

Natsuki Makiguchi

Effect of protein binding on the cellular uptake and antisense activity of cholesterol-conjugated DNA/RNA heteroduplex
oligonucleotide

1P-277

Yusuke Masuo

Optimization of linker sequence of aminopeptidase A-Fc fusion proteins for improvement of enzymatic activity and stability in blood

2P-278A

MADHU BIYANIIn vivo evaluation of a novel circular bivalent DNA aptamer for CYP24A1 inhibition to enhance vitamin D3 functionality in cancer

3P-279Hidetaka Kamimura

Simulation of human serum concentration profiles of canakinumab and M6903 using pharmacokinetic data from common marmosets(Callithrix jacchus) and Microsoft Excel programs

1P-280Ai Yamaguchi

Establishment of a cell culture platform for human liver organoids for evaluating physiological hepatocyte function"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-281

Satoshi Yoshikawa

Decrease of tedizolid concentration during continuous hemodiafiltration is negligible

3P-282

Shijie Wen

CD38 mediates the distinct roles of soluble uric acid and MSU crystals in gouty inflammation

1P-283Jumpei Yokota

Highly functional human intestinal organoids in culture using 3D nanofiber (HYDROX) based on amphiphilic copolymers

2P-284

Toru IWAKI

Effect of Sucrose esters of fatty acid on the solubility of curcumin and hydroxypropyl cellulose solid dispersion

3P-285YANRAN TONG

Culturing human liver organoids using 3D nanofibers derived from chemically synthesized polymers and its application to druginduced liver toxicity test

1P-286

Tatsuya Inui

Development of highly functional intestinal organoids of human iPS cell-derived enterocyte-like cells and their application to drug
discovery research

2P-287J

Miyu Nakayama

Microenvironmental pharmacokinetic/pharmacodynamic analysis of antisense oligonucleotides: in situ hybridization with superresolution microscopy and direct nuclear isolation

3P-288

Mariko Hirano

Prediction of blood IgG levels during therapeutic plasma exchange using the minimal PBPK model

1P-289Masashi Takano

Synthesis of 2-[2-(tetrazol-2-yl)ethyl]-1alpha,25-dihydroxy-19-norvitamin D3 and its metabolism

2P-290Kentaro Okada

Development of a pharmacokinetic evaluation system using human intestinal organoid monolayers focusing on anatomical region
difference.

1P-292Junjia Luo

Anticancer effects of Ginger Exosome-like Nanovesicles on human colorectal cancer

2P-293

Shouta M.M. Nakayama

Evaluation of anticoagulant rodenticides (ARs) sensitivity of warfarin and diphacinone in sea turtles

3P-294

Tai-Long PAN

Hepatoprotective effect of Scutellaria baicalensis against hepatic fibrosis via modulating cytochrome p450 pathway

1P-295

Simone Brixius-Anderko

Deciphering the role of fatty acid metabolizing cytochrome P450 4F11 in lung cancer and its potential as drug target"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.

Presentation time
1P-XXX: 26th September (Tue.) 11:15-12:15
2P-XXX: 27th September (Wed.) 12:30-13:30
3P-XXX: 28th September (Thu.) 11:15-12:15

Poster Presentation
Room F (1F Main Hall - Ocean)
ポスター番号
Poster number

筆頭著者
First name author

演題名
Presentation title

2P-296A

Jiraporn Kuesap

Preliminary study on antimalarial screening of Morinda citrifolia L. crude ethanolic extracts

3P-297

Jeerawat Pimta

Alternariol alleviates Transforming Growth Factor β1-Induced Epithelial to Mesenchymal Transition in Human Renal Proximal Tubular
Cells

1P-298A

Nutnicha Suphakhonchuwong

Association of heme oxygenase-1 (HO-1) polymorphism and malaria parasite density in malaria endemic areas of Thailand

2P-299Kamila Stokowa-Soltys

Nanodiscs as a useful tool to unveil the secrets of cytochrome c reductase.

3P-300

Nipitpon Srimai

Altenusin reduces MDCK-derived cyst progression via CFTR-mediated chloride secretion by activating farnesoid x receptor"A" at the end of the poster number is the subject submitted for the ICCP450 Best Poster Award.
"J" at the end of the poster number indicates the finalist of the JSSX Best Poster Award.