ISID 2023 Tokyo Satellite Meeting

International Symposium on Cutaneous Lymphoma
DateTimeLocation

13 May 2023
16:05-19:05 (JPN)
Takao Room (42nd Floor) at the Keio Plaza Hotel Tokyo～Organizers～ Makoto【Organizers】
Sugaya, MD, PhD (Chair) (Department of Dermaotology, International
University of Health and Welfare, Japan)
 Makoto Sugaya, MD, PhD (Chair) (International University of Health and Welfare, Kazuyasu Fujii, MD, PhD (Department of Dermaotology, Kagoshima UniversityJapan)
Graduate School of Medical and Dental Science, Japan)
 Kazuyasu Fujii, MD, PhD (Kagoshima University Graduate School of Medical and Taku Fujimura, MD, PhD (Department of Dermaotology, Tohoku University Graduate
Dental Science, Japan)
School of Medicine, Japan)
 Taku Fujimura, MD, PhD (Tohoku University Graduate School of Medicine, Japan)
 Hideki Fujita, MD, PhD (Department of Dermaotology, Nihon University School of Hideki Fujita, MD, PhD (Nihon University School of Medicine, Japan)
Medicine, Japan)
 Toshihisa Hamada, MD, PhD (International University of Health and Welfare, Japan)
 Toshihisa Hamada, MD, PhD (Department of Dermaotology, International University of Tomomitsu Miyagaki, MD, PhD (St Marianna University School of Medicine, Japan)
Health and Welfare, Japan)
 Takatoshi Shimauchi, MD, PhD (Hamamatsu University School of Medicine, Tomomitsu Miyagaki, MD, PhD (Department of Dermaotology, St Marianna UniversityHamamatsu, Japan)
School of Medicine, Japan)
 Rei Watanabe, MD, PhD (Osaka University Graduate School of Medicine, Japan)
 Takatoshi Shimauchi, MD, PhD (Department of Dermaotology, Hamamatsu University【Invitedchair】
School ofMedicine,Hamamatsu, Japan)
 Rei Watanabe, MD, PhD (Department of Dermaotology, Osaka University Graduate Samuel Hwang, MD, PhD (Professor and Chair, Department of Dermatology,
School of Medicine, Japan)
University of California, US)～Invited chair～ Samuel T Hwang, MD, PhD (Professor and Chair, Department of Dermatology, Universityof California, Davis, US)◼ 16:05-16:10：Opening remarks by Makoto Sugaya (Chair)◼ 16:10-17:10：Session I (8 min for presentation and 2 min for discussion)
Chair: Samuel Hwang, Taku Fujimura◼ 17:20-17:50：Sponsored Seminar
Minophagen Pharmaceutical Co., Ltd◼ 18:00-19:00：Session II (8 min for presentation and 2 min for discussion)
Chair: Kazuyasu Fujii, Rei Watanabe◼ 19:00-19:05：Closing remarks by Tomomitsu Miyagaki
Co-sponsored by ISID 2023 Tokyo Satellite Meeting & Minophagen Pharmaceutical Co., LtdInternational Symposium on Cutaneous Lymphoma
Agenda◼ 16:05-16:10
Opening remarks by Makoto Sugaya (Chair)◼ 16:10-17:10
Session I (8 min for presentation and 2 min for discussion)
Chair: Samuel Hwang, Taku Fujimura 16:10-16:20
Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumor
growth and increases survival in a murine model○Saptaswa Dey1, Pablo Augusto Vieyra-Garcia1, Aaroh Anand Joshi1, Peter Wolf1
1Department of Dermatology, Medizinische Universitat Graz, Graz, Steiermark,Austria 16:20-16:30
Immunosuppressive macrophage targeting as a therapeutic strategy for cutaneous
T-cell lymphoma○Lauren Banner1, Jonathan Xu1, Emily Hunter1, Tyler Gross1, Sahithi Talasila1,Carla Portocarrero1, Neda Nikbakht1
1Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia,
PA, United States 16:30-16:40
Hyperprogression of cutaneous T cell lymphoma after anti-PD-1 treatment○Yumei Gao1, Yang Wang1
1Department of Dermatology and Venereology, Peking University First Hospital,Beijing, China 16:40-16:50
Treg depletion syndrome: Skin inflammation unleashed by ADCC depleting
biologics○L Gray1, C Larocca1, J Merola1, Thomas Kupper1, J Teague1, A Gehad1,N Gerard1, Q Zhan1, Nicole LeBoeuf1, R Clark1
1Brigham and Women’s Hospital, Boston, MA, United States

Co-sponsored by ISID 2023 Tokyo Satellite Meeting & Minophagen Pharmaceutical Co., Ltd

International Symposium on Cutaneous Lymphoma 16:50-17:00
Ganglioside GD3 leads to the reduction of NK cells in the lesions of cutaneous T celllymphoma○Kei Sakano1, Eiji Kiyohara1, Miki Kume1, Rei Watanabe1, Manabu Fujimoto1
1Department of Dermatology, Graduate School of Medicine/Faculty of Medicine,Osaka University, Suita-shi, Osaka, Japan 17:00-17:10γδ T-cells and NK cells-infusion therapy for adult T cell leukemia-lymphoma○Maho Nakashima1, Yoshimasa Tanaka2, Yasushi Miyazaki3, Hiroyuki Murota1
1Dermatology of Dermatology, Nagasaki University Graduate School of BiomedicalScience, Nagasaki, Japan
2Center for Medical Innovation, Nagasaki University, Nagasaki, Japan
3Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan

17:10-17:20

Break (10 min)

 17:20-17:50
Sponsored Seminar (30 min)<Minophagen Pharmaceutical Co., Ltd>
Chair: Makoto Sugaya

Title: Oral bexarotene as one of current therapeutic options for patients withrefractory CTCL in Japan○Toshihisa Hamada
Department of Dermatology, International University of Health and Welfare Narita
Hospital, Narita, Japan

17:50-18:00 Break (10 min)Co-sponsored by ISID 2023 Tokyo Satellite Meeting & Minophagen Pharmaceutical Co., Ltd

International Symposium on Cutaneous Lymphoma◼ 18:00-19:00
Session II (8 min for presentation and 2 min for discussion)
Chair: Kazuyasu Fujii, Rei Watanabe 18:00-18:10
Single-cell analyses reveal novel molecular signatures and pathogenesis in cutaneous
T cell lymphoma○Xiaotong Xue1, Zhenzhen Wang1, Zihao Mi1, Tingting Liu1, Chuan Wang1,Peidian Shi1, Lele Sun1, Hong Liu1, Furen Zhang1
1Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of
Dermatology and Venereology, Shandong First Medical University & Shandong
Academy of Medical Sciences, Jinan, China
 18:10-18:20
Analysis of novel sezary syndrome genes in mycosis fungoides reveals genes common
across stages and those associated with advanced stages○Jordan Pilkington1, Delice Kayishunge1, Sophia Ly1, Henry Wong1
1Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, UnitedStates 18:20-18:30
High-throughput T cell receptor sequencing aids in the diagnosis of CTCL
○Nana Ama Adjei-Frimpong1, Neda Shahriari1, Christopher Fay1, Cecilia
Larocca1, Thomas Kupper1
1Harvard University, Cambridge, MA, United States 18:30-18:40
Diagnostic validity of t-cell receptor constant beta-chain 1 (trbc1) expression withincutaneous t-cell lymphoma○Olivia Pierog1, Sima Rozati1, Mariah Owosu-Agyei1, David Weiner1, MichaelBorowitz2
1Dermatology, Johns Hopkins University, Baltimore, MD, United States
2Hematologic Pathology, Johns Hopkins University, Baltimore, MD, United States

Co-sponsored by ISID 2023 Tokyo Satellite Meeting & Minophagen Pharmaceutical Co., Ltd

International Symposium on Cutaneous Lymphoma 18:40-18:50
SLFN11 is a possible biomarker of sensitivity to DNA-targeted regents in CD30positive mycosis fungoides and Sezary syndrome○Takatoshi Shimauchi1, Junko Murai2, Manami Iwasaki1, Pawit
Phadungsaksawasdi1, Kazuyasu Fujii3, Tetsuya Honda1
1Department of Dermatology, Hamamatsu University School of Medicine,Hamamatsu, Japan
2Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan
3Department of Dermatology, Kagoshima University Graduate School of Medicaland Dental Science, Kagoshima, Japan 18:50-19:00
Effects of MALT1 Inhibitors on cutaneous T-cell lymphoma cells○Jeffrey Mayo1, Loka Reddy Velatooru1, Xiaohong Wang1, Madeleine Duvic1, Xiao
Ni1
1Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX,United States◼

19:00-19:05

Closing remarks by Tomomitsu Miyagaki

Co-sponsored by ISID 2023 Tokyo Satellite Meeting & Minophagen Pharmaceutical Co., Ltd