ADVANCES IN POLYAMINE RESERACH
Satellite Symposium"COST917: POLYAMINES IN TUMOURGROWTH"PROGRAM★
ORAL SESSIONS[COST917: POLYAMINES AND CANCER]
Chair persons: D. M. L. Morgan and A. Messina
1. E. Holtta (Helsinki, Finland)
Do polyamines regulate cell transformation?
2. H. C. Ha, P. M. Woster, R. A. Casero, Jr. (Baltimore and Detroit, USA)
Polyamines as poisons and protectors
3. J. L. Urdiales, M. A. Medina, J. Ramirez, J. Ruiz-Chica, I. Fajardo, F.
Sanchez-Jimenez (Malaga, Spain)
Common biochemical roles of ornithine-derived polyamines andhistamine
4. R. Schipper, A. Faber, A. Verhofstad (Niimegen, The Netherlands)
Role of polyamines in normal and malignant growth of prostatic cells
5. A. Perin, P. Tunici, E. Rabellotti, A. Sessa (Milano, Italy)

Polyamines in N-ethyl-N-nitrosourea-induced gliomsas
6. S. Bettuzzi, G. Guidetti, A. M. Verrone, P. Davalli, G. Ferrari, A. Corti(Modena, Italy)
Transcript coding for polyamine biosynthetic and degradative enzymes
and ornithine decarboxylase antizyme in human prostate carcinoma[AMINE OXIDASES]
Chair persons: K. Wallace and B. Mondovi
1. P. Pietrangeli, S. Nocera, X. T. Wang, B. Mondovi, L. Morpurgo (Roma,Italy)
Inactivation of bovine serum amine oxidase by polyamines
2. C. Binda, R. Angelini, R. Federico, A. Mattevi (Pavia and Roma, Italy)
Three-dimensional structure of polyamien oxidase from Zea mays L.
3. P. Tavladoraki, M. E. Schinina', F. Cecconi, M. Laurenzi, S. Di Agostino,
F. Manera, G. Rea, P. Mariottini, R. Federico, R. Angelini (Roma, Italy)Maize polyamine oxidase: primary structure from protein and cDNA
sequencing
4. M. Laurenzi, J. P. Knox, R. Federico, R. Angelini, M. J. McPherson(Roma, Italy and Leeds, UK)
Developmental regulation of copper amine oxidase in pea and lentil
5. G. Rea, R. D'Ovidio, S. Bonanni, P. Tavladoraki, R. Federico, R. Angelini,
M. J. McPherson (Roma, Italy)
Spatial and temporal expression pattern of copper amine oxidase in Cicer
aretinum L. and its role in wound-healing

[COST917: POLYAMINES AND INHIBITORS I.]
Chair persons: E. Holtta and A. Perin
1. L. Persson, E. Lovkvist Wallstrom, S. Nasizadeh, A. Jeppsson, A. Wendt,
J. Holmgren, P. Andersson, C. Dartsch (Lund, Sweden)
Regulation of ornithine decarboxylase
2. H. M. Wallace, D. M. Evans, J. T. Affolter, S. Chopra, G. S. Lindsay, S.
Lamond, J. Duthie (Aberdeen, UK)
Alternations in polyamine metabolism in response to anti-cancer therapy
3. F. A. J. Muskiet, B. Dorhout (Groningen, The Netherlands)
In vitro and in vivo manipulation of L1210 cell cycle kinetics withDFMO, CGP48664A and N1-actylspermine
4. C. Vargiu, S. Colombatto (Torino, Italy)
Antiproliferative effect of medroxyprogesterone acetate on MCF7 cells isassociated with alterations in polyamine metabolism
5. A. Khomutov, T. Voinova, V. Djavakhia, R. Khomutov (Moscow, Russia)
Functional activity of hydroxylamine-containing inhibitors of ODC andSMADC[POLYAMINES AND INHIBITORS II.]
Chair persons: S. Otani and B. Tadolini
1. V. Milovic, A. R. Khomutov, L. Turchanowa, R. M. Khomutov. W. F.
Caspary, J. Stein (Frankfurt, Germany and Moscow, Russia)

Simultaneous inhibition of ODC and SAMDC activity: a promisingtherapeutic approach in colorectal cancer?
2. M. Caraglia, M. Marra, A. Leardi, S. Pepe, A. Fabbrocini, P. Tagliaferri, A.
Abbruzzese (Napoli, Italy)
Desferioxamine increases iron depletion and apoptosis induced by ara-C
on human myeloid leukaemic cells
3. F. Flamigni, C. Capanni, A. Facchini, C. Stefanelli, S. Marmiroli, C. M.
Caldarera (Bologna, Italy)
Inhibitors of phosphatidylinositol 3-kinase prevent the induction ofornithine decarboxylase in leukaemia cells
4. M. Peska, M. Mateuffel-Cymborowska, W. Chmurzynska, B.
Grzelakwska-Szabert (Warsaw, Poland)
Anticancer drugs influence ornithine ecarboxylase (ODC) andspermidine/spermine N1-acetyltransferase (SSAT) gene expression in injured
mouse kidney
5. C. Aubel, H. Chabanon, L. Persson, M. Ferrara, P. Brachet (Saint-Genes
Champanelle, France and Lund, Sweden)
Effect of amino acid deprivation on polyamine transport and metabolism
in human tumour cells[POLYAMINE HOMEOSTASIS]
Chair persons: J. L. A. Mitchell and C. M. Caldarera
1. J. L. A. Mitchell, G. Judd (DeKalb, USA)
Polyamine homeostasis, antizyme modification and mitochondria
2. S. Matsufuji (Tokyo, Japan)

Signals for antizyme frameshifting and their involvement in polyamine
stimulation
3. C. Zhu, P. Coffino (San Francisco, USA)A second antizyme gene
4. I. Matsui-Yuasa, T. Nakatani, D. O. Kennedy, Y. Murakami, Y. Yano, S.
Otani (Osaka, Japan)
Restricted Zn2+ availability affects the antiziyme-dependent ODCdegradation pathway in isolated primary cultured rat hepatocytes
5. S. Bettuzzi, R. Tiozzo, S. Astancolle, R. Roncaglia, F. Boraldi, A. Corti(Modena, Italy)
Cell cycle dependent changes in the expression of the regulatory
enzymes of polyamine metabolism and ornithine decarboxylase antizyme
6. G. Pintus, B. Tadolini, M. Maioli, A. M. Posadino, G. G. Pinna, S.
Bettuzzi, S. Milia, C. Ventura (Sassari, Italy)
Inhibition of serum- and phorbol ester-induced ODC gene expression byheparin in HUVECs[TRANSPORT OF POLYAMINES AND INTERACTION WITH
MACROMOLECULES]
Chair persons: K. Igarashi and N. Bagni
1. K. Igarashi, H. Tomitori, K. Sakata, A. Kuraishi, K. Kashiwagi, D. G.
Vassylyev, K. Morikawa (Chiba and Osaka, Japan)
Polyamine transport in Escherichia coli and animal cells
2. F. Antognoni, S. Del Duca, A. Kuraishi, E. Kawabe, T.
Fukuchi-Shimogori, K. Kashiwagi, K. Igarashi (Chiba, Japan)

Transcriptional inhibition of the spermidine uptake operon by thesubstrate binding PotD protein
3. A. Bozac, A. Toninello (Pdova, Italy)
Effect of spermine on permeability transition in brain mitochondria
induced by calcium plus phosphate
4. K. Kashiwagi, A. J. Pahk, T. Masuko, K. Igarashi, K. WIlliams (Chiba,Japan and Philadelphia USA)
Regulation of N-methyl-D-aspartate receptors by polyamines:
identification of amino acid residues involved in the regulation
5. L. Nicolini, A. Lentini, S. Melino, R. Petruzzelli, A. Abbruzzese, S.
Beninati (Roma, Chieti, Napoli, Italy)
Transglutaminase-catalyzed post-translational modification of calpain IIand its substrates is involved in rabbit eye lens opacification
6. J. A. Creus, X. Feixa, J. Barcelo' (Bellaterra, Spain)
Free and bound polyamine levels in Zea mays cultivars differing inanminium tolerance
7. F. Monti, A. M. Bregoli, S. Biondi, S. Del Duca, D. Serafini-Fracassini(Bologna, Italy)First evidence for a transglutaminase involvement in plant apoptosis[COST917: DIETARY REGIMENS AND TUMOUR GROWTH]
Chair persons: S. Bardocz and C. Clo'
1. R. Penafiel, C. Ruzafa, F. Monserrat, A. Cremades (Murcia, Spain)Effect of dietary arginine on polyamine metabolism and growth ofmurine melanoma; influence on renal size
2. S. Bardocz, G. Grant, A. Ralph, A. Pusztai, I. F. Pryme (Aberdeen, UKand Bergen Norway)
Dietary polyamiens in tumour growth
3. C. Loser, A. Eisel (Kiel, Germany)
Feeding of polyamine-deficient diets significantly inhibits DMH-inducedcolon carcinogenesis in rats
4. I. F. Pryme, A. Pusztai, S. Bardocz, S. W. B. Ewen (Bergen, Norway andAberdeen , UK)
Dietary polyamines and growth of a murine non-Hodgkin lymphoma[REGULATION OF ODC, SAMDC AND SSAT]
Chair persons: L. Persson and S. Beninati
1. S. Otani, T. Omura, Y. Yano, T. Hasuma, I. Matsui-Yuasa (Osaka, Japan)
Polyamine metabolism and retinoblastoma protein phosphorylation in
hepatocyte proliferation
2. L. Manzella, E. Conte, C. Bonaiuto, G. Cocchiaro, E. Guarniera, A.
Messina (Catania, Italy)
Role of IRF-1 in ODC gene expression during monocytic differentiation
3. C. Cabella, C. Vargiu, C. Cravanzola, S. Belliardo, M. A. Grillo, S.
Colombatto (Torino, Italy)
Mofulation of polyamine content in hepatocytes by agmatine

4. M. Franceschetti, S. Scaramagli, C. Hanfrey, A. J. Michael (Bologna, Italyand Norwich, UK)
Characterisation of S-adenosylmethionine decarboxylase and spermidine
synthase gene families of Arabidopsis
5. S. Scaramagli, S. Grillo, A. Leone, P. Torrigiani (Bologna, Italy)
Polyamine response to low water potential in potato cultured cells
6. L. Turchanowa, B. I. Feldkoren, V. A. Rogozkin, V. Milovic, J. Stein(Frankfurt, Germany and St. Petersburg, Russia)
Polyamine synthesis is up-regulated by physical loading in the skeletal
muscle[COST917: FUNCTIONS OF POLYAMINES]
Chair persons: R. A. Casero adn A. Toninello
1. U. Bachrach (Jerusalem, Israel)
Polyamines regulate protein kinase activities and signal transduction
processes
2. D. M. Morgan (London, UK)
Polyamine regulation of nitric oxide production in LMS-activatedmacrophages
3. F. Bonavita, I. Stanic, F. Flamigni, M. Mignani, C. Clo', B. Tantini, C.
Pignatti, C. Stefanelli, C. M. Caldarera (Bologna and Parma, Italy)
Polyamines influence caspase activity
4. R. Ientile, G. Cannavo' I. Picerno, T. Ginoprelli, C. Fabiano, G.
Piedimonte (Messina, Italy)

Increases in polyamine biosynthesis are required for cell cycle transition
and HIV-induced cell death
5. R. Hochreiter, T. M. Weiger, S. Colombatto, T. Lagner, C. Cabella, W.
Heidegger, M. A. Grillo, A. Hermann (Salzburg, Austria and Torino, Italy)
The effect of polyamines and diamine analogues on the proliferation ofC6 glyoma cells. An in vitro and molecular modelling study
6. N. Bagni, M. M. Altamura, R. Biasi, G. L. Calzoni, R. Crinelli, A. DeStradis, G. Falasca, M. Franceschetti, C. Neri, V. Scoccianti, A. Speranza, G.
Teti (Bologna, Roma, Potenza and Urbino, Italy)
Polyamines and sexual reproduction in kiwifruit
7. M. L. van Buuren, S. Fornale', M. Franceschetti, L. Guidi, G. F. Soldatini,
N. Bagni (Bologna and Pisa, Italy)
The role of polyamines in tobacco ozone resistance
8. M. de Agazio, M. Zacchini, A. Marotta, Z. El Gawhary (Roma, Italy)
Exogenous spermidine as a tool to investigate stress response in plants[INTERACTION OF POLYAMINES WITH MACROMOLECULES]
Chair persons: R. Penafiel and D. Serafini-Fracassini
1. A. Tassoni, R. Napler, N. Bagni, M. A. Venis (Bologna, Italy andWarwick, UK)
Purification of a specific spermidine-binding protein from maize (Zeamais L.) coleoptiles
2. F. Galli, U. Buoncristiani, L. Nicolini, A. Lentini, S. Benedetti, F.
Canestrari, S. Beninati (Roma and URbino, Italy)

Polyamineated peptides in uremic blood
3. A. M. Bregoli, S. Del Duca, C. Neri, C. Bergamini, D. Serafini-Fracassini(Bologna adn Ferrara, Italy)
Purification and characterization of pollen transglutaminase
4. S. Scaramagli, S. Biondi, F. Capitani, M. M. Altamura, P. Torrigiani(Bologna, Roma, Milano, Italy)
Inverse relationship between polyamine coniugate levels/ethylene
biosynthesis and vegetative bud formation in tobacco★