YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
SDS No.00280-011
October 12, 2023
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Safety Data Sheet
１． PRODUCT AND COMPANY IDENTIFICATION
Product Name:
Product number:
Manufacturer:First issue:

September 18, 2015

Human s-IgA(Saliva) ELISAYK280YANAIHARA INSTITUTE, INC.
Address:
2480-1, Awakura, Fujinomiya-shi
Shizuoka, Japan 418-0011
Tel:+81-544-22-2771(Japan)
Fax:+81-544-22-2770
E-mail:ask@yanaihara.co.jp
Eleventh issue:
Oct. 12, 2023

２． HAZARDS IDENTIFICATIONGHS classification
Classification of the substance or mixture 3), 5)
Acute toxicity - Inhalation (Dusts/Mists)
Category 4
Skin corrosion/irritation
Category 1, 2
Serious eye damage/eye irritation
Category 1, 2ASpecific target organ toxicity (single exposure)
Category 1
Category 1 respiratory system, cardiovascular system, kidneys, nervous system
Specific target organ toxicity (repeated exposure)
Category 1
Category 1 respiratory system, cardiovascular system, liver, digestive system, blood system,
kidneys, pancreas, thymus, central nervous system
Germ cell mutagenicity
Category 1B
Reproductive Toxicity
Category 1B
Pictograms

Signal word
DangerHazard statements
H314 - Causes severe skin burns and eye damage
H315 - Causes skin irritation
H317 – May cause an allergic skin reaction
H318 - Causes serious eye damage
H319 - Causes serious eye irritation
H332 - Harmful if inhaled
H340 - May cause genetic defects
H360 - May damage fertility or the unborn child
H370 - Causes damage to the following organs: respiratory system, cardiovascular system,YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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kidneys, nervous system
H372 - Causes damage to the following organs through prolonged or repeated exposure:respiratory system, cardiovascular system, liver, digestive system, blood system,
kidneys, pancreas, thymus, central nervous system
Precautionary statements-(Prevention)
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fumes/gas/mist/vapors/spray.
Wash face, hands and any exposed skin thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Precautionary statements-(Response)
Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin withwater/ shower.
IF INHALED: Remove victim to fresh air and keep comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
IF exposed: Call a POISON CENTER or doctor/physician.
Call a POISON CENTER or doctor/physician if you feel unwell.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.
Wash contaminated clothing before reuse.
Precautionary statements-(Storage)
Store locked up.
Store in a well-ventilated place. Keep container tightly closed.
Precautionary statements-(Disposal)
Dispose of contents/container to an approved waste disposal plant
OthersOther hazards

Not available

Other reagents may be harmful if inhaled and ingested.

May cause eye and skin irritation.

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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３． COMPOSITION, INFORMATION ON INGREDIENTS1)
Product Name
Human s-IgA (Saliva) ELISACAS Number
None

Kit components:
No.
1)

Component
Antibody coated plate

Quantity
1 plate2）
3)Standard
HRP labeled antibody solution

10 μg
12 mL

4)
5)
6)
7)

8)

Enzyme substrate solution(TMB)
Stopping solution
Buffer solution(concentrated 2x)
Washing solution(concentrated)

12 mL

Chemical namePlate coated with mouse anti human s-IgA
monoclonal antibody ①
Purified human s-IgA②
HRP labeled goat anti human IgA (αchain)antibody ③
Phenol ④
Chloramphenicol ⑤3,3’,5,5’-Tetramethylbenzidine ⑥

12 mL
25 mL

Sulfuric acid (1M) ⑦
Buffer containing a reaction accelerator ⑧

50 mL

Sodium chloride ⑨
Polyoxyethylene sorbitan monolaurate(Tween20) ⑩

Adhesive foil

3 piecesWt%

CAS No.

Chemical Formula

0.096%
0.02%
No
information
9.69%

108-95-2
56-75-7
54827-17-7

C6H5OHC11H12Cl2N2O5
C16H20N2

7664-93-9

H2SO4

18%

7647-14-5

NaCl

1%

9005-64-5

C58H114O26

４． FIRST AID MEASURES
Inhalation:
Immediately remove victim to fresh air. Consult a physician if necessary.
Eye contact: Immediately flush eyes with flooding amounts of running water for at least 15
minutes. Consult a physician if necessary.
Skin contact: Immediately remove contaminated clothes and shoes, flush skin with plenty ofwater or shower. Wash contaminated clothing and shoes.
Consult a physician if necessary.
Ingestion:
Immediately seek medical attention.
５． FIRE FIGHTING MEASURES
Flammable properties:
Nonflammable
Extinguishing media:
Foam, Carbon dioxide, dry chemical powder, soil, waterFire fighting instructions:
May emit toxic fumes under fire conditions. Wear full fire fighting
protective equipment including self-contained breathing apparatus.
Do not contact to the components when extinguish fire.
６． ACCIDENTAL RELEASE MEASURES
Personal precautions:Remove all ignition sources and ventilate. Wear suitable protective
equipment. Avoid contact with skin and eyes. Keep off except persons
concerned.
Environmental precautions: Prevent spills from entering sewers, watercourses or low area, and preventfrom affecting environment.
Methods for Clean up:
In case of spill of liquid material, take up or cover spilled material withashes or other incombustible absorbents, and put in a container to be sealed.
After completely picked up, dispose. In case of spill of solid or powdermaterial, prevent causing dust, sweep and collect, and put in a container tobe sealed. Wash the spill site with water.

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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７． HANDLING AND STORAGE
Handling:

Storage:

Obtain a package insert before use.
Read all the cautions for safety in the package insert before use.
Avoid strong light.
Avoid contact, inhalation and swallow.
Use only in open air or ventilated area.
Prevent from entering eyes.
Ventilate the area to keep concentration in air below exposure limits.
Avoid inhalation of mist, vapor and spray of material.
Avoid contact with eyes, skin and clothing.
Do not smoke and eat while using this kit.
Wash hands thoroughly after handling.
Prevent from entering environment.
Handle materials with suitable protection.
Use suitable equipments.
Do not pipette by mouth.
Do not leak, overflow and scatter.
Do not fall down and damage.
Store away from sunlight in a cool and dark place at 36-47ﾟF (2-8ﾟC).

８． EXPOSURE CONTOROLS, PERSONAL PROTECTION
Engineering measures:

General ventilation and/or local exhaust ventilation as well as process isolationis necessary to minimize employee exposure and maintain exposure limits below
exposure limits. Equip eye flushing facilities and shower rooms near operating
place where this kit is handled or stored.

Control parameter:④JSOH (Japan);
ACGIH TLV(s);⑦JSOH (Japan);
ACGIH TLV(s);TWA= 5 ppm OEL
TWA= 19mg/m3 OEL Skin
TWA= 5 ppm Skin
OEL= 1 mg/m3
TWA= 0.2 mg/m3

Personal protection:
Respiratory protection; NIOSH and MSHA approved respirator.
Hand protection;
Suitable impervious gloves.
Eye protection;
Suitable safety glasses (goggles).
Skin protection;
Suitable protective clothing.
Others:Wash hands thoroughly after handling materials.

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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９． PHYSICAL AND CHEMICAL PROPERTIES
Component

1)

2)

3)

4)

5)

6)

7)

8)

Appearance

Colorlessplate

White color,lyophilized
powderOrange color,
LiquidColorless topale yellow
liquidColorlesstransparent,
LiquidColorlesstransparent,
LiquidColorlesstransparent,
LiquidColorlesstransparent
Polymersheet

pHMelting point

N/A
N/A

N/A
D/N/A

6.8-6.9
N/A

3.3-3.8
N/A

<1.0
N/A

D/N/A
N/A

D/N/A
N/A

N/A
N/A

Boiling point

N/A

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Flash point

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Explosive limits

N/A

D/N/A

D/N/A

Not explosive

D/N/A

D/N/A

D/N/A

N/A

Vapor pressure

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Vapor density(air=1)

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

Specifics gravity

D/N/A

D/N/A

D/N/A

1.01

D/N/A

D/N/A

D/N/A

D/N/A

Solubility in water

Insoluble

SolubleMixableMixableMixableMixableMixableInsoluble

Decomposition
temperature

N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

D/N/A

N/A

N/A: Not applicable
D/N/A: data not available

10． STABILITY AND REACTIVITY
Chemical stability:
Shelf life:
Hazardous polymerization:
Conditions to avoid:

Product is stable under normal handling.
Stable up to 24 months after manufacturing.
Will not occur.
Extremes of temperature and direct sunlight, heat, flames andsparks, static electricity, spark, moisture
Incompatibility with other materials: Alkaline substances, metals, strong oxidizing agents
Hazardous decomposition products:
Sulfur oxides(SOx), Carbon monoxide(CO), carbon dioxide(CO2),
Nitrogen oxides(NOx)

11． TOXICOLOGICAL INFORMATION
Information as the mixture is not available.
Acute toxicity:3) Phenol (oral, rat); LD50=340 - 530mg/kg Category 4(dermal, rabbit); LD50=630mg/kg(dermal, rat); LD50=669.4mg/kg Category 3(inhalation, rat); 8h LC50 >900mg/m3 Classification not possible④Content=0.096% Classification not possible
Chloramphenicol (oral, rat); LD50=2500mg/kg Not classified
4) Not classified5) Sulfuric acid (inhalation, rat); 4h LC50=347ppm(Oral, rat) LD50=2140mg/kg
Acute toxicity (Oral) Category 5
Acute toxicity (Inhalation: Dusts and mists) Category 2⑦Content=9.69% Acute toxicity (Inhalation: Dusts and mists) Category 3

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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7) Tween 20 (oral, rat); LD50=37000mg/kg
Inhalation (rat); >5.1mg/L, 4h
Skin corrosion/irritation:3) Phenol; Category 1④Content=0.096% Not classified
Chloramphenicol; Classification not possible
4) Not classified (TMB)
5) Sulfuric acid; Category 1⑦Content=9.69% Category 1
7) Tween 20 ; No information available
Serious eye damage/irritation:3) Phenol; Category 1④Content=0.096% Not classified
Chloramphenicol; Classification not possible
4) Not classified5) Sulfuric acid; Category 1⑦Content=9.69% Category 1
7) Tween 20; No information available
Respiratory or skin sensitization:
Respiratory sensitization
3) Phenol; Classification not possible
Chloramphenicol; Classification not possible
4) Not classified5) Sulfuric acid; Classification not possible
7) Tween 20; No information available
Skin sensitization:3) Phenol; Not classified
Chloramphenicol; Classification not possible
4) Not classified5) Sulfuric acid; Not classified
7) Tween 20; No information available
Germ cell mutagenicity:3) Phenol; Category 2④Content=0.096% Category 1B
Chloramphenicol; Category 2⑤Content=0.02% No information available4) Not classified5) Sulfuric acid; Classification not possible
7) Tween 20; No information available
Carcinogenicity:YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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7/123) Phenol; Not classified IARC group 3 (1999) (substances which cannot beclassified to human carcinogens), ACGIH: A4 (2005), IRIS: D (2002)
Chloramphenicol; Category 1B IARC group 2A (substances which may be
carcinogenic to human)⑤Content=0.02% No information available4) Not classified5) Sulfuric acid; Occupational exposure to Mist of inorganic strong acids
including sulfuric acid is classified to group 1 in IARC (to havecarcinogenicity for human ), group A2 in ACGIH (suspected
human carcinogens) and group K in NTP (known to havecarcinogenicity for human). With respect for the evaluation by
IARC and current evaluation by NTP, it should be classified tocategory 1, however since sulfuric acid itself is classified toCategory 4 in DFGOT and is not classified to carcinogen by anyother organization,
Classification not possible
7) Tween 20; No information available
Reproductive toxicity:3) Phenol; Category 1B④Content=0.096% Not classified
Chloramphenicol; Category 1B⑤Content=0.02% No information available4) Not classified5) Sulfuric acid; Not classified
7) Tween 20; No information available
Specific target organ systemic toxicity/Single exposure:3) Phenol; Category 1 (nervous system, respiratory organs, cardiovascularsystem, kidney)④Content=0.096% Not classified
Chloramphenicol; Classification not possible
4) Not classified5) Sulfuric acid; Category 1 (Respiratory system)⑦Content=9.69% Category 2
7) Tween 20; No information available
Specific target organ systemic toxicity/Repeated exposure:3) Phenol; Category 1 (central nervous system, cardiovascularsystem, blood system, liver, kidney)④Content=0.096% Not classified
Chloramphenicol; Category 1 (Hematopoietic system, nervous system,
circulatory system, digestive organ)⑤Content=0.02% No information available4) Not classified5) Sulfuric acid; Category 1 (Respiratory system)YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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⑦Content=9.69% Category 2
7) Tween 20; No information available
Aspiration hazard:

3) Phenol; Classification not possible
Chloramphenicol; Classification not possible
4) Not classified5) Sulfuric acid; Category 1 (Respiratory system)⑦Content=9.69% Category 2
7) Tween 20; No information available

12． ECOLOGICAL INFORMATION
Information as the mixture is not available.
Aquatic environmental toxicity/Acute phase:3) Phenol; Ceriodaphnia: LC50=3.1mg/L/48h Category 2④Content=0.096% Not classified
Chloramphenicol; 72h EC50=0.78mg/L (Desmodesmus subspicatus) Category 1⑤Content=0.02% No information available4) No data available.
5) Sulfuric acid; 96h LC50=16-28mg/L for fish (Lepomis macrochirus)
Category 3⑦Content=9.69% Not classified
7)Tween 20; No information available
Aquatic environmental toxicity/Chronical phase:3) Phenol; Category 2④Content=0.096% Not classified
Chloramphenicol; Category 1⑤Content=0.02% No information available4) No data available.
5) Sulfuric acid; 24h LC50=29mg/L for crustacea (Daphnia magna)
Category 1⑦Content=9.69% Not classified
7) Tween 20; No information available
Persistence and degradability:
3) Phenol; Classification not possible
Chloramphenicol; Classification not possible
4) No additional information available5) Sulfuric acid; No information available
7) Tween 20; No information available
Bioaccumulative potential:
3) Phenol; Classification not possible

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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Chloramphenicol; Classification not possible
4) No additional information available5) Sulfuric acid; No information available
7) Tween 20; No data available
Mobility in soil:
3) Phenol; Classification not possible
Chloramphenicol; Classification not possible
4) No additional information available5) Sulfuric acid; No information available
7) Tween 20; No information available
Hazard to the ozone layer:3) Phenol; Classification not possible
Chloramphenicol; Classification not possible
4) No additional information available5) Sulfuric acid; Classification not possible
7) Tween 20; No information available
13． DISPOSAL CONSIDERATIONS
Dispose of all waste material including containers in accordance with all applicable laws and local
environmental regulations.

YK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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14． TRANSPORT INFORMATION
ADR/RID

Sulfuric acidUN number

UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Marine pollutant

8IINot applicable

IMDG
UN number

Sulfuric acid
UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Marine pollutant

8IINot applicable

Transport in bulk according toAnnex II of MARPOL 73/78 andthe IBC CodeNo information available

IATA
UN number

Sulfuric acid
UN2796

Proper shipping name:Sulfuric acid

UN classification
Packing group
Environmentally Hazardous
Substance

8II
Not applicableYK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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15． REGULATORY INFORMATIONInternational Inventories
EINECS/ELINCS
TSCAJapanese regulations
Fire Service Act;
Poisonous and Deleterious Substances Control Law;
Industrial Safety and Health Act;Act on the Evaluation of Chemical Substances andRegulation of Their Manufacture, etc.;
Regulations for the carriage and storage of
dangerous goods in ship;
Civil Aeronautics Law;

Air Pollution Control Law;
Marine Pollution Prevention Law;
Act on Confirmation, etc. of Release Amounts ofSpecific Chemical Substances in the Environment
and Promotion of Improvements to theManagement Thereof (Pollutant Release andTransfer Register Law/ PRTR)；
Water Pollution Control Act；
Export Trade Control Order；⑦Listed⑦ListedNot applicableNot applicable⑦Group 3 Specified Chemical Substance, (Ordinanceon Prevention of Hazards Due to Specified Chemical
Substances Art.2 Para.1, Item 6)④⑦Harmful Substances Whose Names Are to be
Indicated on the Label (Law Art.57, Para.1,
Enforcement Order Art.18)④⑦Notifiable Substances (Law Art.57-2, Enforcement
Oder Art.18-2 Attached Table No. 9) No.474④, No.613⑦④Priority Assessment Chemical Substances (Law
Article 2, Para.5)⑦Corrosive Substances(Ordinance Art.3, Ministry ofTransportation Ordinance Regarding Transport by Shipand Storage, Attached Table 1)⑦Corrosive Substances(Ordinance Art.194, MITL
Notification for Air Transportation of Explosives etc. ,Attached Table 1)④Specified Substances, Hazardous Air Pollutants⑦Specified substance⑦Enforcement ordinance Appendix No. 1 Noxious
liquid substance Category Y
Not applicable④⑦Specified substances(Law Art.2 Para.4,
Enforcement Order Art.3-3)
Not applicableYK280 Human s-IgA(Saliva) ELISAYANAIHARA INSTITUTE, INC.
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16. OTHER INFORMATION
Reference and abbreviation
1) Internal data of Yanaihara Institute, Inc.
2) SIDS（2001）
3) RTECS : Registry of Toxic Effects of Chemical Substances.
4) NTP DB (Access on Dec., 2005), National Toxicology Program5) SDS by FUJI FILM Wako Pure Chemical Corporation
6) ACGIH(2004): American Conference of Governmental Industrial Hygienists7) JSOH : Japanese Society of Occupational Health
Recommendation of Occupational Exposure Limits (2021-2022)
8) NIOSH: National Institute of Occupational Safety and Health9) MSHA: Mine Safety and Health Administration
10) IARC(1992): International Agency for Research on Cancer
11) DFGOT: Occupational Toxicants: Critical Data Evaluation for MAK Value and Classification ofCarcinogens, Vol. 15, 2001
12) SDS by Bio-Rad laboratories, Life Science GroupKey literature references and sources for data etc.;
NITE: National Institute of Technology and Evaluation (JAPAN) http://www.safe.nite.go.jp/japan/db.html
IATA dangerous Goods Regulations, RTECS: Registry of Toxic Effects of Chemical Substances, Japan
Industrial Safety and Health Association GHS Model SDS, Dictionary of Synthetic Organic Chemistry,
SSOCJ, Koudansha Scientific Co. Ltd. , Chemical Dictionary, Kyouritsu Publishing Co., Ltd. etc.
The above information is believed to be correct to be the best of our knowledge and information,
But does not purport to be all inclusive and should be used as only a guide. This product is intended
to be used by expert persons having chemical knowledge and skill, at their own discretion and risk.
Yanaihara institute shall not be held liable for any damages resulting from handling or contact withthe above product. Users should determine the suitability of the information for their particularpurpose.