氏名

松原よみ

まつばらたつあき

英字MATSUBARA

Tatsuaki

プロフィール達昭

複数の一般病院において臨床研鑽を積んだ後、名古屋大学大学院医学系研究科内科学講座（循環器内科）助教授、愛知学院大学歯学部内科学講座教授として、教育、研究、診療に携わり、2021年4月より現職。

職位特任教授、大学院研究科長

最終学歴

名古屋大学医学部医学科

学位
所属学会・役職
専門分野

医学博士
日本内科学会（認定内科医）、日本循環器学会（循環器専門医）、日本糖尿病学会（糖尿病専門医）、日本高血圧学会（高血圧専門医）、日本脈管学会（特別会員）、日本心臓病学会（特別正会員）
内科学、循環器学、糖尿病学

研究テーマ
生活習慣病のゲノム/エピゲノム情報、糖尿病に関わる心血管疾患、動脈硬化と炎症
主な教育・研究及び 〈著書〉
社会的活動及び業績 1.松原達昭：総説．松原達昭編．「循環器病への挑戦」シリーズ25 メタボリックシンドロームと心血管病．ライフメディコム，11-30, 2006.
（過去20年）
2.松原達昭：感染性心内膜炎．千葉俊美他編．歯科医師のための内科学．医歯薬出版，114-119, 2021.
3.Matsubara T：8 Cardiovascjlar Diseases, 4 Infective Endocardtitis. Chiba T, et al eds.
Internal Medicine for Dental Treatments. Springer, 130-136, 2023.
〈和文論文〉
1. 松原達昭：マグネシウム動態を考慮した循環器疾患の診療．マグネシウム 27:3-12, 2008.
2. 松原達昭：私と高血圧．血圧 23:892-894, 2016.
3. 松原達昭：特集7 心不全×糖尿病をもつ患者さんの薬物療法．HEART nursing 36:1062-1071, 2023.
〈欧文論文〉
1. Ishii H, Matsubara T, et al: Impact of a single intravenous administration of nicorandil
before reperfusion in patients with ST-segment-elevation myocardial infarction. Circulation
112:1284-1288, 2005.
2. Naruse K, Matsubara T, et al: Therapeutic neovascularization using cord blood-derived
endothelial progenitor cells for diabetic neuropathy. Diabetes 54:1823-1828, 2005.
3. Kokubo M, Matsubara T, et al: Noninvasive evaluation of the time course of change in cardiac
function in spontaneous hypertensive rats by echocardiography. Hypertension Research 28:601609, 2005.
4. Ishii H, Matsubara T, et al: Effects of intravenous nicorandil before reperfusion for acute
myocardial infarction in patients with stress hyperglycemia. Diabetes Care 29:202-206, 2006.
5. Amano T, Matsubara T, et al: Impact of metabolic syndrome on tissue characteristics ofangiographically mild to moderate coronary lesions. Integrated backscatter intravascularultrasound study. Journal of the American College of Cardiology 49:1149-1156, 2007.
6. Amano T, Matsubara T, et al: Abnormal glucose regulation is associated with lipid-richcoronary plaque. Relationship to insulin resistance. JACC - Cardiovascular Imaging 1:39-45,
2008
7. Kobayashi M, Matsubara T, et al: Dobutamine stress testing as a diagnostic tool forevaluation of myocardial reserve in asymptomatic or mildly symptomatic patients with dilated
cardiomyopathy. JACC - Cardiovascular Imaging 1:718-726, 2008.
8. Uetani T, Matsubara T, et al: The correlation between lipid volume in the target lesion,
measured by integrated backscatter intravascular ultrasound, and post-procedural myocardial
infarction in patients with elective stent implantation. European Heart Journal 29:1714-1720,
2008.
9. Ishii H, Matsubara T, et al: Pharmacological intervention for prevention of left ventricularremodeling and improving in myocardial infarction. Circulation 118:2710-2718, 2008.
10. Aoyama T, Matsubara T, et al: Sirolimus-eluting stents vs bare metal stents for coronary
intervention in Japanese patients with renal failure on hemodialysis. Circulation Journal
72:56-60, 2008.
11. Uetani T, Matsubara T, et al: The association between plaque characterization by CTangiography and post-procedural myocardial infarction in patients with elective stentimplantation. JACC - Cardiovascular Imaging 3:19-28, 2010.
12. Yamada S, Matsubara T, et al: Prognostic value of reduced left ventricular ejection
fraction at start of hemodialysis therapy on cardiovascular and all-cause mortality in endstage renal disease patients. Clinical Journal of American Society of Nephrology 5:1793-1798,2010.
13. Matsubara T, et al: Impact of pitavastatin on high-sensitivity C-reactive protein andadiponectin in hypercholesterolemic patients with the metabolic syndrome: The PREMIUM Study.
Journal of Cardiology 60:389-394, 2012.
14. Morita I, Matsubara T, et al: Relationship between periodontal status and levels ofglycated hemoglobin. Journal of Dental Research 91:161-166, 2012.

implantation. JACC - Cardiovascular Imaging 3:19-28, 2010.
12. Yamada S, Matsubara T, et al: Prognostic value of reduced left ventricular ejection
fraction at start of hemodialysis therapy on cardiovascular and all-cause mortality in endstage renal disease patients. Clinical Journal of American Society of Nephrology 5:1793-1798,2010.
13. Matsubara T, et al: Impact of pitavastatin on high-sensitivity C-reactive protein andadiponectin in hypercholesterolemic patients with the metabolic syndrome: The PREMIUM Study.
Journal of Cardiology 60:389-394, 2012.
14. Morita I, Matsubara T, et al: Relationship between periodontal status and levels ofglycated hemoglobin. Journal of Dental Research 91:161-166, 2012.
15. Lee JY, Matsubara T, et al: A genome-wide association study of a coronary artery diseaserisk variant.Journal of Human Genetics 58:120-126, 2013.
16. Kato N, Matsubara T, et al: Trans-ancestry genome-wide association study identifies 12
genetic loci influencing blood pressure and implicates a role for DNA methylation. Nature
Genetics 47:1282-1293, 2015.
17. Nakatochi M, Matsubara T, et al: Epigenome-wide association study suggests that SNPs in thepromotor region of RETN influence plasma resistin level via effects on DNA methylation atneighbouring sites. Diabetologia 58:2781-2790, 2015.
18. Omi M, Matsubara T, et al: Transplantation of dental pulp stem cells improves long-term
diabetic polyneuropathy together with improvement of nerve morphometrical evaluation. Stem Cell
Research and Therapy 8:279, 2017.
19. Nakatochi M, Matsubara T, et al: Epigenome-wide association of myocardial infarction withDNA methylation sites at loci related to cardiovascular disease. Clinical Epigenetics 9:54,
2017.
20. Takeuchi F, Matsubara T, et al: Interethnic analysis of blood pressure loci in populationsof East Asian and European descent. Nature Communications 9:5052, 2018.
21. Hata M, Matsubara T, et al: Transplantation of human dental pulp stem cells ameliorates
diabetic polyneuropathy in streptozotocin-induced diabetic nude mice: the role of angiogenic
and neurotrophic factors. Stem Cell Research and Therapy 11:236, 2020.
22. Chen J, Matsubara T, et al: The trans-ancestral genomic architecture of glycemic traits.
Nature Genetics 53:840-860, 2021.
23. Hata M, Matsubara T, et al: Sustainable effects of human dental pulp stem celltransplantation on diabetic polyneuropathy in streptozotocin-induced type 1 diabetes model
mice. Cells 10:2473, 2021.
24. Yamauchi T, Matsubara T, et al: Impacts of glucose-dependent insulinotropic polypeptide on
orthodontic tooth movement-induced bone remodeling. International Journal of Molecular Sciences
23:8922, 2022.
25. Kondo S, Matsubara T, et al: Increased expression of angiopoietin-like protein 4 regulates
matrix metalloproteinase-13 expression in Porphyromonas gingivalis lipopolysaccharidesstimulated gingival fibroblasts and ligature-induced experimental periodontitis. Journal ofPeriodontal Research 58:43-52, 2023.
〈研究代表者として獲得した科学研究費〉
1. 基盤研究（C）メタボリックシンドロームに及ぼす歯周病の影響についての総合的研究（2006-2007）
2. 基盤研究（C）歯周病がメタボリックシンドロームに及ぼす直接作用の解析（2010-2012）
3. 基盤研究（B）地域住民を対象としたエピゲノム疫学基盤の構築（2013-2016）
4. 基盤研究（C）生活習慣病におけるゲノム/エピゲノム情報の前向きコホート研究による検証（20202025）〈社会的活動〉
・一般社団法人 健康評価施設査定機構 理事
・特定非営利活動法人 日本医学歯学情報機構 顧問
・株式会社 Mizkan Holdings 「ヒト試験審査部会」部会員
・たんぽぽ薬局株式会社倫理審査委員会 副委員長