Guidance for Making Data Access Requestof Genome Sequence Archive for Human

Introduction ....................................................................................................... 2User Registration .............................................................................................. 2Making Data Access Request .......................................................................... 5
Waiting for Review .......................................................................................... 12
Data Download ................................................................................................ 141Introduction
The Genome Sequence Archive for Human (GSA-Human), as a part of Genome
Sequence Archive (GSA) in the National Genomics Data Center (NGDC), is a datarepository specialized for human genetic related data derived from biomedical
researches. Two different services of data access are provided by GSA-Human: Openaccess and Controlled-access. For Open-access, data are public for global
researchers. While for Controlled-access, data can only be downloaded after being
authorized by its Data Access Committee (DAC), which means making a successful
data access request.
This documentation is aimed to give detailed guidance on how to make a data accessrequest for Controlled-access data via GSA-Human System.

User Registration
Step 1. Register Account in BIG Single Sign-On (BIG SSO) System of NGDC andLogin
It is important to note that only the Principle Investigator (PI) of the research group canbe allowed to apply for Controlled-access data. Besides, before making a data accessrequest, you are supposed to register an account via BIG Single Sign-On (BIG SSO)
and sign in (See Figure below).
If you are the PI of the group and already had an account, just go to Step 2; Or if you
are the staff or student of the group, please be sure to invite the PI of your group toregister an account via BIG SSO, as well as you can use the PI’s information to do itafter permission.
If you have any problems during the process mentioned above, please feel free tocontact gsa@big.ac.cn. Once finish Step 1, you can go to Step 2.

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Step 2. Complete the PI information in GSA-Human System
With an account of PI, you can go to the GSA-Human pages directly via BIG
Submission (BIG Sub). As can be seen in the following figure, however, if it’s the firsttime for you to use this system, you are supposed to complete the required informationof PI.
For Personal Homepage, please provide a web-link to your personal homepage inyour research institution or laboratory.
Note: This information is aimed to improve your reliability as well as the success rateof your data access request, since DAC may review your homepage and researchareas, and so on. While if you do not have the homepage link, other types of links canbe accepted, such as the articles that you published as the corresponding author or
the public website which contains your personal information.

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Making Data Access Request
There are two ways to enter the request system to make a new request:
Click the navbar: Browse, find the data you are willing to request via Search Bar, click
the “Request” button

5Then, please follow the steps listed below to make your Data Access Request:
Step 1. Fill Basic Information – the title of your request

Step 2. Fill Research Information – tell the DAC how you will use this data inyour research, including Research Activity Title, Choose research period,
Research purpose, Methods & techniques.

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Step 3. Study information – type in the Study Accession of the data you want toapply (such as HRA000067), and you can easily review the basic information ofthe data, including Study Title, Use and Limitation, Data Access Agreement.

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Step 4. Overview – you can review your request information on this page

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Step 5. Agreement – you have to sign the Data Access Agreement, via Online
signature or Offline signature.

91. For Online signature, this page provides three methods: Upload a signature picture,generate a signature by using mouse, and Create a signature automatically. Using
the third methods as an example, the following process can be seen below:

10Note: After generating and submitting the signature, your request will be
submitted to the system and appear in your request list. In addition, its statuswill be “Finished | Waiting for Curation”. Please wait for the system admin doing
the first check for you. Before the request being checked, you can freely cancel,
modify, review your request.

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2. For Offline signature, the process is as follows:•••

Please click the “DAA Download” button and download the DAA file of this study.
After that, please “upload” button to upload the Scanned DAA file. For thedomestic users, please prove the scanning copy of DAA document with thesignature of you and your organization and the stamp of your organization. Forinternational users, please prove the scanning copy of signed DAA documentfrom you and your organization.
Then please wait for the system admin doing the first review for you. Before therequest being reviewed, you can freely cancel, modify, review your request.

Waiting for Review
After submitting the request successfully, it may take some time for being reviewed byboth system and the DAC, thanks for your patient. Once you have passed the review,12congratulation, you will be approved to download the data.
System Review: The system admin will do the first and basic review for you. Please
fill in all of the required information carefully. For instance, if your identity is not reliable
enough (miss the Personal Homepage information) or lack of required documentation,
your request will be rejected. If the request has be approved, its status will be “Waitingfor DAC review”; otherwise, its status will be “Rejected”. Please click the “ReviewHistory” to check the detail of the feedback.
DAC Review: The requests that passed the System Review will be transferred to theDAC Review. While passing the DAC Review, you will receive a notification by email,so please pay attention to your email. If the request has be approved, its status will be“Approved Download”; otherwise, its status will be “Rejected”. Please click the“Review History” to check the detail of the feedback.
If the DAC does not give their feedback after two weeks, the system will send an email
to notify them automatically. There are differences among the frequency of DAC
contacts processes the request. You can check the last processed time or the numberof approved requests by searching the accession you requested in the browse page(https://ngdc.cncb.ac.cn/gsa-human/browse/).
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The columns of the “requests” show the number of requests that users
submitted.
The columns of the “approve” show the number of requests that DAC contact’sapproved.
The columns of the “last processed” show the last time that DAC contact’s login
in the GSA-Human database.

If the DAC has not processed the request for a long time, you can try toemail the DAC contacts to get the real reasons. Please follow the steps below to findthe DAC contacts’ email.
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Open the browse page (https://ngdc.cncb.ac.cn/gsa-human/browse/) and findthe dataset that you requested.
Click the study accession of the dataset to enter the dataset browsing page, andyou can find the DAC contact person's email in Data Access Committee part.

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NOTICE: If the dataset data not yet been registered in the Human Genetic Resource
Management Platform of Ministry of Science and Technology of the People´s Republicof China, the international users are unavailable to request this dataset currently.
Please wait until the owners get the Registration and backup numbers from Human
Genetic Resource Management Platform.

Data and Metadata table Download
After passing the review, the status of your request in the list will become “Approved”.
For downloading metadata table, please login and open the dataset you requested in
the browsing page, like https://ngdc.cncb.ac.cn/gsa-human/browse/HRA000067.
Then click the table download button as following picture below.

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For downloading data file, you are able to click the “download” link and download thedata from the data directory directly via FTP with your account login.

As downloading data through the website is not stable, we highly recommend you use
an FTP client to sign into our FTP server for big data downloading, such as FileZilla.
Taking FileZilla as an example, you can download the data following four steps:
Step 1. download and install FileZilla (https://filezilla-project.org/ ), as shown in the
figure below, click “Download FileZilla Client” and install the software following theguidance.

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Step 2. Open FileZilla (see figure below), input the Host as “human.big.ac.cn”, Userand Password are the same as your account (the login email and password), do notneed to fill in the port, finally, click “Quickconnect”. The status in the message log willshow you have login successfully. If not, please check the issues based on themessage shown in the log.
Step 3. After login, in the local pane, set where you want to save the data.
Step 4. In the remote pane, double click the folder of the dataset, such as“HRA000219”, and just drag the files/directories from the remote pane to the localpane.

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