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専門分野

主な論文・著作・業績①Yokota, S., et al. (5th in 5 authors): Extracellular adenosine 5ʹ-diphosphate promotes MCP-1/CCL2 expression
via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-likesynoviocytes. Mol. Biol. Rep., 50: 1595-1602, 2023.
②Takizawa, N., et al. (12th in 13 authors): Bone marrow-derived mesenchymal stem cells propagate

石崎

明

生化学講座
細胞情報科学分野

常態系口腔科学関連教授

博士（歯学）

病態系口腔科学関連
腫瘍生物学関連

immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners
under hypoxic culture., Exp. Cell Res., 358: 411-420, 2017.
③Kanno, Y., et al. (2nd in 12 authors): Plasminogen/Plasmin modulates bone metabolism by regulating theosteoblast and osteoclast function.

J. Biol. Chem., 286: 8952-8960, 2011.

④Ishisaki, A., et al. (1st in 4 authors): Human umbilical vein endothelium-derived cells retain potential todifferentiate into smooth muscle-like cells. J. Biol. Chem., 278: 1303-1309, 2003.
⑤Ishisaki, A., et al. (1st in 9 authors): Differential Inhibition of Smad6 and Smad7 on bone morphogenetic proteinand activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem., 274: 13637-13642, 1999.
①Chosa N., Ishisaki A. "Two novel mechanisms for maintenance of stemness in mesenchymal stem cells:
SCRG1/BST1 axis and cell-cell adhesion through N-cadherin". Japanese Dental Science Review, 54:37-44, 2018.
②Suzuki K.*, Chosa N.*, Sawada S., Takizawa N., Yaegashi T., Ishisaki A. "Enhancement of anti-inflammatory andosteogenic abilities of mesenchymal stem cells via cell-to-cell adhesion to periodontal ligament-derived
fibroblasts". Stem Cells International, 2017:3296498, 2017. *co-first authors.

帖佐直幸

生化学講座
細胞情報科学分野

准教授

博士（地球環境科学）

常態系口腔科学関連
医科学関連
免疫学関連

③Inoue M., Yamada J, Aomatsu-Kikuchi E., Satoh K., Kondo H., Ishisaki A., Chosa N. "SCRG1 suppresses LPSinduced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells". Molecular Medicine
Reports, 15:4069-4076, 2017.
④Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N. "NovelSCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stemcells". Scientific Reports, 4:3652, 2014.
⑤Jang I.H.*, Chosa N.*, Kim S.H., Nam H.J., Lemaitre B., Ochiai M., Kambris Z., Brun S., Hashimoto C., Ashida M.,
Brey P.T., Lee W.J. "A Spatzle-processing enzyme is indispensable for Toll signaling activation in Drosophila innate
immunity". Developmental Cell, 10:45-55, 2006. *co-first authors.

①Yokota S., Chosa N., Kyakumoto S., Kimura H., Ibi M., Kamo M., Satoh K., Ishisaki A. "ROCK/actin/MRTF
signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibularjoint". International Journal of Molecular Medicine, 39:799-808, 2017.
②Takizawa N.*,Okubo N.*,Kamo M.,Chosa N.,Mikami T.,Suzuki K.,Yokota S.,Ibi M.,Ohtsuka M.,Taira M.,YaegashiY.,Ishigaki A.,Kyakumoto S. "Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/antiinflammatory macrophages in cell to cell contact-independent and -dependent manners under hypoxicculture".Experimental Cell Research, 358:411-420,2017.*co-first authors.
③Nemoto A.,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Noda M.,Ishisaki A.,"Water-soluble factors eluated from横田聖司

生化学講座
細胞情報科学分野

講師

博士（歯学）

常態系口腔科学関連

surface pre-reached glass ionomer filler promote osteoblastic differentiation of human mesenchymal stem

病態系口腔科学関連

cells".Molecular Medicine Reports. 17:3448-3454. 2018.
④Ohta M.*,Nemoto A.*,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Shibata S.,Joh S.,Satoh K.,Ishisaki A. "Toll-likereceptor 4-mediated signaling activated by lipopolysaccharide suppresses transforming growth factor-betainduced nerve growth factor expression in periodontal ligament-derived fibroblasts".Dental Journal of Iwate
Medical University. 43:61-73. 2018.*co-first authors.
⑤Ohta M.,Chosa N.,Kyakumoto S.,Yokota S.,Okubo N.,Nemoto A.,Kamo M.,Joh S.,Satoh K.,Ishisaki A. "IL-1β andTNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts throughinactivational of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals".International Journal of MolecularMedicine. 43:1484-1494. 2018