HUPO 10th Annual
World Congress,(HUPO2011)

President Address in AOHUPO Newsletter 2011

Kazuyuki Nakamura President of AOHUPO (2011-2013)

September 4-7, 2011
Geneva, Switzerland

INSIDE THIS ISSUE

President of AOHUPO

1

KHUPO Meeting

3

China HUPO Conference

4

TPS Annual Symposium

6

12th HUPO Congress Poster 7
Upcoming Events

8

Asian Oceania Human
Proteome Organizationwww.aohupo.org

I have the honor of giving president
address in AOHUPO Newsletter. I was
officially nominated to be the 3rd
President of AOHUPO (2011-2013) bystrong supports of council members lastyear. Drs. Young-Ki Paik (Korea) for Past
President, Fuchu He (China) and Bill
Jordan (New Zealand) for Vice President
and Maxey Chung (Singapore) for
Secretary General have cordially accepted
my invitation to be AOHUPO EC
members. Dr. Jordan is kindly serving as
Director of Membrane Proteome Initiative(MPI) for the promotion of the AOHUPO
Initiative1). Drs. Ghasem Hosseini
Salekdeh (Iran) and YuJu Chen (Taiwan)
have accepted my invitation to join the
AOHUPO EC meeting as Chair and CoChair of AOHUPO human embryonicstem cell (hESC)-MPI. Dr. Salekdeh also
serving as the Editor of AOHUPO
Newsletter. I have another importantmission to promote Education andTraining (E&T) for young scientists in
AO region. Dr. Ravi Sirdeshmukh (India)
has worked nicely to organize Education
Day at the 5th AOHUPO Conference inHyderabad in February, 2011. I proposed
to have the standing committee of
AOHUPO E&T in 2008 with Drs.
Mathew Perugini (Australia), Siqi Liu(China), Ghasem Hosseini Salekdeh(Iran), Tosifusa Toda (Japan), In-Chul
Kang (Korea), Nikhat Ahmed Siddiqui(Pakistan), Jisnuson Svasti (Thailand) andSponsors of E&T Workshop/Seminar. We
had nice meeting of the 9th HUPO World
Congress in Sydney where I asked Drs.
Richard Simpson and Stuart Cordwell(Australia), Pengyuan Yang (China),

Visith Thongboonkerd (Thailand), Ho
Jeong Kwon (Korea), and Hisashi
Hirano (Japan) to support E&T
activities. HUPO E&T Committee
chaired by Dr. Thierry Rabilloud(France) is active to organize Education
Day at each of HUPO World Congressand Hands-on Course in each ofcountries. Dr. Peter James (Sweden)
hasproposedtheInternational
Proteomics Tutorial Program topromote the publication of articles ofTutorial in HUPO official journals with
Dr. Rabilloud and myself. The global
collaboration on E&T will give us“Place” for bringing up young people
to be experts in the field ofproteomics2). Dr. Terence Poon (HongKong) and Dr. Jordan will take the leadin organizing the Asia roadshow of
HUPO New Technology & Resources
Committee chaired by Dr. Christoph
Borchers(Canada).
Globalcollaboration of AOHUPO council
members is essential to make “Place”
in AO region and strong support by
HUPO EC members especially Dr. Paik
as Past President and Dr. Simpson as
Secretary General of HUPO, Dr. He as
Chair of the 6th AOHUPO Conferencein Beijing in May, 2012, and Drs.
Hirano and Naoyuki Taniguchi andmyself as Co-Chairs of the 12th HUPO
World Congress in Yokohama in
September, 2013.
I am Professor and Chairman in the
Department of Biochemistry andFunctional Proteomics, Yamaguchi
University
Graduate
SchoolofMedicine, Ube, Japan, and haveworked in the principle of proteomics
to understand protein functions in thestates of human physiology andpathology. I earned my degree of MD.
Ph.D. from Yamaguchi University withstudies on coenzyme-binding sites on
NADandNADP-dependent
dehydrogenasesbyAffinity
Electrophroesis3). It was very nice forPage 1

me to promote my scientific career in the Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, NIH,
Bethesda, USA. The studies on post-translational modifications on glutamine synthetase in E. Coli4) led me toproteomics. I returned to Yamaguchi University School of Medicine where we succeeded in the development of a novel
technique of Two-dimensional Affinity Electrophoresis by which antigen-specific antibodies in anti-sera could be
separated into homogenous protein spots by differences in their isoelectric points and affinity to the antigen immobilized
in gel matrices5). I had started proteomics on stress-induced apoptosis in Jurkat cells of a human lymphoblastic leukemia
cell line to find proteins which are involved in the stress response6). It was found that Stathmin was hyperphosphorylated by CDK1 in temperature dependent manner7). I am now interested in the discovery of biomarkers andtherapeutic targets for HCV-related Hepatocellular Carcinoma and Pancreatic Cancer using two-dimensional gel
electrophoresis combined with tandem mass spectrometry8), and in the development of Cys-tag-Protein Chips for highthrough-put analyses of protein-protein interactions9). My interest is shifting to Membrane Proteomics, Cancer
Immunology and Immuno-Proteomics for the development of new diagnostic tools and non-invasive curative treatmentsof malignant tumors. I have been serving for the promotion of human proteomics as an inaugural member of HUPO andthe member of HUPO Council, Education & Training (E&T) Committee, HUPO Test Sample Study10), the co-chair of
Human Disease Glycomics Proteome Initiative (HGPI)11), the advisory member of Human Kidney and Urine Proteome
Project (HKUPP), and Past President of Japan HUPO and Japanese Electrophoresis Society. The mission for me is topromote E&T of graduate students and young scientists being experts in the field of functional proteomics and clinicalproteomics for understanding Molecular System of Life.
Finally I would like to show my deep thanks for your good thoughts and supports to Japan after the disaster on March
11th, 2011. The people in the area having the big damage by the earthquake and tsunami are still struggling to rebuild
their daily life and to be free from the fear of nuclear fallout. Although it will take time to recover from the damage andthe fear, I believe we can make our country better than before the disaster with your strong supports.
References:
1) The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterizationof the carbonate-washed membrane standard. Peng L., et al. Proteomics, 10(22), 4142-4148 (2010)2) Japan HUPO for Promotion of Global Collaborations in Human Proteomics. Nakamura K. and Hirano H. Mol. Cell.
Proteomics, 7(12), 2486-7 (2008)
3) Study of the interaction between NADP-dependent dehydrogenase and immobilized adenosine 2’-monophosphate bymeans of affinity electrophoresis. Nakamura K., et al. J. Chromatogr. A, 196, 85-99 (1980)
4) Oxidative inactivation of glutamine synthetase subunits. Nakamura K. and Stadtman E. R. Proc. Natl. Acad. Sci.
USA, 81, 2011-2015 (1984)
5) Affinity electrophoresis and its applications to studies of immune response. (Review) Nakamura K. and Takeo K. J.
Chromatogr. B, 715, 125-136 (1998)
6) Differential expression of nucleophosmin and stathmin in human T lymphoblastic cell lines, CCRF-CEM and
JURKAT analyzed by two-dimensional gel electrophoresis. Nakamura K., et al. Electrophoresis, 16, 1530-1535 (1995)
7) Analysis on heat stress-induced hyperphosphprylation of stathmin at serine 37 in Jurkat cells by means of twodimensional gel electrophroesis ant tandem mass spectrometry. Nakamura K., et al. J. Chromatogr. A, 1106(1-2), 181189 (2006)
8) Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers.(Review) Kuramitsu
Y. and Nakamura K. Proteomics, 6(20), 5650-5661 (2006)
9) A novel approach of protein immobilization for protein chips using an oligo-cysteine tag. Ichihara T., et al. J.
Proteome Res., 5(9), 2144-2151 (2006)
10) A HUPO test sample study reveals common problems in mass spectrometry-based proteomics. Bell A.W. et al.
Nature Methods, 6, 423-430 (2009)11) Comparison of the methods for profiling glycoprotein glycans-HUPO Human
Proteome Glycomics/Proteome Initiative Multi-institutional study. Wada Y., et al.
Glycobiology, 17(4),411-22 (2007)

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11th Annual KHUPO International Meeting
March 31st - April 1st, 2011, Busan, Korea
In conjunction with the 10th anniversary of KHUPO, the Korean Human Proteome Organization (KHUPO) held
the 11th Annual KHUPO International Meeting at Inje University Haeundae Paik Hospital, Busan, Korea from the
31st of March to the 1st of April 2011. The theme of this meeting was “Proteomics: Past and Future.
The 11th KHUPO2011 in Busan hosted about 370 attendees including about 35 speakers from USA, Japan,
Sweden, Swiss, France, Iran, Australia, China, Taiwan, Russia, Korea etc. and 62 participants from the 9 different
company exhibitioners. This Conference provided the proteomics viewpoints of proteome biology and technology,
its application to human disease, and drug development. Major proteome-related organizations in Korea, Korea
Cancer Society and JHUPO’s members etc attended this meeting. Three outstanding plenary lecturers presented
knowledge-based human protein atlas project (Dr. Mathias Uhlen), the study of chromosome 17 in Human
Proteome Project (Dr. William s. Hancock), identification and functional analysis of co- and post-translational
modifications of large protein complexes (Dr. Hisashi Hirano). This year in memory of the 10th anniversary of
KHUPO, we had special lecture of Andrew Marshall, the editor of Nature Biotechnology. He gave very usefullecture regarding ‘How to get published in Nature Biotechnology’. This meeting provided the exchange of newscientific information with 10 symposia in the areas of PTM & proteome biology, proteome biomarkers, proteome
informatics, new technology in proteomics for molecular diagnostics, quantitative proteomics disease proteomics,
integrated omics, frontier in proteomics, clinical proteomics, proteomics in drug development. In this meeting,outstanding 117 posters were presented by students and researchers. Among them, 15 of the poster presenterswere awarded as outstanding Young Scientist Awards. Also, in memory of KHUPO 10th anniversary, KHUPO
published 10-year KHUPO history book at the welcome reception dinner cruise in this meeting
This 11th KHUPO international meeting in Busan also provided liaison meeting of 4th HUPO Human Proteome
Project (HPP) Working Group Workshop on March 30, 2011, held in Novotel Ambassador Busan at Haewoondae
Ocean Beach Resort, Busan. This meeting was organized by Young-Ki Paik, the president of HUPO, Pierre
Legrain and Gil Omenn. This satellite meeting was very fruitful in providing the information on the progress andwheeling prospective about the HPP (which was officially launched last year at Sydney HUPO).
Detailed information and programs of the 11th KHUPO international meeting are available at
http://www.khupo.org/meeting.

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Proteomics and Translational Medicine
The Seventh China HUPO Annual Conference & The third International Forum of Proteomics
April 15-18, 2011, Hangzhou, China

The 7th CNHUPO Annual Congress and the 3rd International Forum of Proteomics organized by CNHUPO and IFP, wasjointly held in the leisure metropolis, Hangzhou, China from April 15th to 18th, 2011.This jointly conference was cochaired by Prof. Fuchu He of State Key Laboratory of Proteomics, Prof. Peipei Ping of University of California, Los
Angeles (UCLA), Prof. Huilong Duan of Zhejiang University and Prof. Jun Qin from Beijing Proteome ResearchCenter (BPRC).
This international conference, with the theme of “Proteomics and Translational Medicine”, attracted over 800 scientists
from China and many from all over the world as well. Spreading over three days, the conference featured 21 keynotes
and 94 outstanding speakers. All speakers were featured in 15 different sessions, including proteomics-relatedtranslational medicine, bioinformatics of protein science, visualizing human proteomes, chemical proteomics, diseaseproteomics, functional proteomics, and proteomics related technologies. The training courses and lectures were
provided in the afternoon of April 14th to over eighty students and young scientists. The opening ceremony was held in
the first day of the conference.
Renowned scientists around the world made brilliant speeches on frontier academic studies of proteomics andtechnology progress in the conference. These speeches are professors as listed: John Yates of Scripps Research Institute,
Catherine Costello of Boston University School of Medicine, Gilbert Omenn of University of Michigan, Mathias Uhlenof Royal Institute of Technology, Christopher Overall of the University of British Columbia, Amos Bairoch of Swiss
Institute of Bioinformatics, Rolf Apweiler of European Bioinformatics Institute, Lokesh Joshi of National University of
Ireland, Henry Rodriguez of National Institutes of Health, Daniel Chan of Johns Hopkins University, Mark Baker ofMacquarie University, Jennifer Van Eyk of Johns Hopkins University, Pothur Srinvas of National Institutes of Health,Peipei Ping of UCLA, Zhu Chen of Minister of Health in China, Fuchu He of China State Key Laboratory ofProteomics, Zihe Rao of Tsinghua University, Shusen Zheng of Zhejing University, Yukui Zhang of Dalian Institute ofChemical Physics, CAS, Xuemin Zhang of Academy of Military Medical Science, and Jun Qin of Beijing Proteome
Research Center. Besides, a total of ten overseas Chinese scientists were invited to chair different sessions and gave
wonderful speeches, such as Xiaodong Cheng, Jianjun Li, Qingyi Wei and Lei Li all from University of Texas Medical
Branch, Min Li from John Hopkins University School of Medicine, Chenwei Lin from Fred Hutchinson Cancer
Research Center, Bing Su from Yale University, Rong Wang from Mount Sinai School of Medicine, and Billy Wu from
Northeastern University. All participants enjoyed this nationwide conference and were updated with the newest
achievements in the field of Proteomics and translational Medicine.

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Two mini-symposiums were held during the conference as well. One was an International Consulting Meeting focusing
on the Chinese Human Proteome Project (CNHPP)and Pilot Hub Of ENcyclopedical proteomIX (PHOENIX), and theother was the 1st China-Europe Symposium on Functional Glycoproteomics: Technology and Clinical Application. In
the International Consulting Meeting, Profs. Xiaohong Qian and Jun Qin briefly overviewed CNHPP and PHONEIX,
respectively. Over fifty scientists including Gilbert Omenn, Catherine Costello, Rolf Apweiler, Daniel Chan, Mark
Baker, Rong Wang, etc. attended and discussed wide range of significance related to the proposal and progression of
CNHPP and PHONEIX. The 1st China-Europe Symposium focused on the technology development for the functional
glycoproteomics study and their application on clinical side. The symposium was co-chaired by Prof. Ping Xu fromBPRC and Prof. Lokesh Joshi from National University of Ireland Galway. Twenty scientists from six different
countries and officials from both sides of China and European, including Dr. Fuchu He, President of China Human
Proteome Organization (CNHUPO), Dr. Xiaoming Jin, Director General of Department of International Cooperation,
Ministry of Science and Technology of China, Dr. Philippe Vialatte, Head of the Science, Technology and Environment
Section of the European Union Delegation to China, Dr. Tomasz Dylag, Project Officer, European Commission,
attended the symposium.

To encourage young researchers, twelve abstracts were selected from a total of 245 abstracts as oral presentations in thesession of “Young Investigator Award Competition”. Six of them won the Young Investigator Awards. Meanwhile,
twelve outstanding posters from 130 candidates were voted by committee as “Best poster”.
The conference partially supported by 35 companies in the world and 6 local media corporations. Ten vendor
companies conducted workshops. Every attendant can appreciate new products and technology developed by theparticipating companies. The exhibition halls were equipped with buffet dinner and soft drinks. People chatted under the
lively communication atmosphere.
The CNHUPO council meeting was held in the evening of April 16 with forty members attended. Prof. Xiaohong Qiansummarized work of the 2nd CNHUPO Executive committee, followed by the election for the 3rd executive committee.
Prof. Fuchu He was elected as honored president of CNHUPO; Prof. Pengyuan Yang was elected as president of the 3rd
executive committee, Prof. Ping Xu was elected as secretary general. Prof. Xiaohong Qian, Jun Qin and Xiangmei Chen
were elected as vice presidents of CNHUPO.
Awarding ceremony for Poster and Young Investigator presentation winners was held during the closing ceremony of
the conference. At the end, Prof. Pengyuan Yang summarized outcomes of the conference and announced the closing of
the 7th CNHUPO Annual Congress and the 3rd International Forum of Proteomics.
The next CNHUPO conference will be held in Chongqing, China in 2013.

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2011 TPS Annual Symposium, Taipei, April 27-28
The “Translational Medicine Conference and Taiwan Proteomics Society Annual Symposium 2011” was recently
held at National Yang-Ming University (NYMU), Taipei, Taiwan. In this conference, four keynote lectures, six
symposia, poster sections and exhibition were organized. We aim to put together an exciting scientific program
addressing how recent progress in quantitative shotgun proteomics, protein post-translational modification
analysis, system biology and bioinformatics can collectively advance the frontiers of clinical proteomics. The 2day event attracted over 300 participants, with 80 posters and 21 invited lectures from both foreign and local
scientists, including a Russian team of nine delegates. Dr. Cheng-Wen Wu, a Distinguished Chair Professor at
NYMU, gave a special keynote lecture of ‘Translational Research of Lung Cancer in Taiwan’ to provide
perspectives about proteomics in translational medicine. Dr. Andrew H.-J. Wang at Academia Sinica had an
invited lecture on the application of structural proteomics to drug discovery. Dr. Alexander I. Archakov from
Russian Academy of Medical Sciences led the Russian delegation to promote the Taiwan-Russian Joint
Proteomics Research program. He also presented the prospective and progress on ‘From Human Genome Projectto Human Proteome Project’, heading s series of reports about the progress on. The symposium further provided
opportunities for local student and young participants to present their work through lecture and poster
communications, which covered many different fields of proteomics, including translational medicine, biomarker
discovery, biomarker assays, technical advances, protein modification and bioinformatics.

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UPCOMING EVENTS
July
2011

9th Annual Conference of Japan Human Proteome
Organization (Japan Proteome Society 2011)
July 28-29, 2011
Niigata, Japan

September
2011

HUPO 10th Annual World Congress, (HUPO2011)
September 4-7, 2011
Geneva, Switzerland

December2011

http://www.jhupo.org/

http://www.hupo2011.com"International Conference on Omics Meets Disease&
IIIrd Annual Meeting of Proteomics Society (India)"
Organized by Saha Institute of Nuclear Physics (SINP), Indian
Institute of Chemical Biology (CSIR-IICB) & University of Calcutta,
Kolkata, INDIA

December 15 – 18, 2011

SINP Auditorium Complex, Salt Lake, Kolkata, India

Any material submitted will be subject to approval by the AOHUPO
Executive Committee and the Publications Committee
AOHUPO EC members:
President: Kazuyuki Nakamura (Japan)(nakamura@yamaguchi-u.ac.jp)
Past President :Young-Ki Paik (South Korea)(paikyk@yonsei.ac.kr)
Vice President: Fuchu He (China)(hefc@bmi.ac.cn)
Vice President: Bill Jordan (New Zealand)(Bill.Jordan@vuw.ac.nz)
Secretary General: Maxey C.M. Chung (Singapore)(bchcm@nus.edu.sg)
Directors of Human Embryonic Stem Cell MPI:
Ghasem Hosseini Salekdeh (Iran)(h_salekdeh@abrii.ac.ir)
Yu-Ju Chen (Taiwan) (yjchen@chem.sinica.edu.tw)

If you wish to contribute news, noticesof events, or any other items, pleasefeel free to forward it to AOHUPO
Newsletter Office:Iranian Proteomics Society
P.O. Box (31535- 1897), Karaj, Iran.
Telfax : +98-261-2702893
Email: h_salekdeh@abrii.ac.ir
Newsletter Editor :Ghasem Hosseini Salekdeh (Iran)Page 8