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৿‫;ٶڷ‬ೋ࣑੓Τ΢ϩη‫״‬ઝ঳͹༩๹Ͷ༙ް͵ϭέοϱΏ৿ͪ͵࣑ྏ๑͹ཱི֮Ν໪ࢨ ˗ॕकҾࢢΝඬదͶͪ͢߇ &ͤɽ৿‫ܗ‬΢ϱϓϩΦϱδΤ΢ϩηͶଲ͢ͱϕϪϏϱυϝρέ෈‫׈‬Կϭέοϱ͗ඍஜ͠Η ‫ܗ‬،ԎΤ΢ϩηࡐ͹֋൅
ͱ͏Ζɽ͖͢͢ɼླྀߨ‫͗ה‬༩଎Ͳ͘͵͏͞ͳɼંझ‫ްޛ‬Վ͗ड़ΖΉͲௗ‫͖͖ؔغ‬Ζ͞ͳ͗ ໲ୌࢻ͠Ηͱ͏Ζɽͨ͞Ͳɼୱյંझʀ୻‫Ͳؔغ‬΍༙ް͵ૌ‫͓׷‬ਫ਼ϭέοϱ౵ͶΓΖ༩๹๑͹ཱི֮Ν໪ࢨͤɽΉͪɼ& ‫ܗ‬،ԎΤ΢ϩηɼ% ‫ܗ‬،ԎΤ΢ϩη౵࣍କ‫״‬ઝԿͤΖΤ΢ϩ˗& ‫ܗ‬،ߙร࣑ྏ༂͹֋൅˗৿‫ܗ‬΢ϱϓϩΦϱδ༩๹ϭη࣮‫׳‬͹࣑ྏͺࠖೋͲ͍ΖɽΤ΢ϩη෵੣Νཊ੏ͤΖ֫࢐ΠψϫήΏϕϫτΠʖκ૏֒ έοϱ͹֋൅ࡐ౵࣑͗ྏͶ༽͏ΔΗͱ͏Ζ͗ɼ༂ࡐଳ੓Τ΢ϩη͗ड़‫͢ݳ‬ҝ͚ɼशਫ਼౦༂࣑ྏ͗චགྷ 

Ͳ͍Ζɽͨ͞ͲɼॕकҾࢢΝඬదͶͪ͢߇Τ΢ϩηࡐͳ໖ӺͶΓΖഋঈ‫ܧ‬͹‫׈͵ྙک‬੓ ˗υϱή೦༩๹ϭέοϱ͹֋൅ԿΝ΍ͪΔͤ͞ͳͲɼ͞ΗΔ࣑ࠞࠖೋ͵Τ΢ϩη࣮‫׳‬͹‫׮‬સ͵බସ੏‫ޜ‬Ν໪ࢨͤɽճ ㄆ▱⑕࡜⚄⤒㞴⑓ Πϩςύ΢ϜʖබΏϏʖΫϱλϱබɼϪϑʖঘର‫ܗ‬೟எ঳ʤ'/%ʥɼ઴ಆଈಆཁร੓঳

˗ϏʖΫϱλϱබͶ͕͜Ζࡋ
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ɼ‫۔‬Ҧक़੓ଈࡩߙԿ঳ʤ$/6ʥɼଡ‫ܧ‬౹Ҧक़঳ɼ੺ਹঘ೶ร੓঳౵Ͳட੷ͤΖҡ ৙஁പ࣯ʤνΤɼЍ εϊέϪ΢ϱɼ7'3ɼϛϨήϩνϝϱ౵ʥ͹൅‫ؽݳ‬঄ͳਈ‫ࡋܨ‬๖ ˗ЎΠϝϫ΢χͶଲͤΖ '1$ร੓գఖ͹մ໎ͶΓΕɼ͞ΗΔ೟எ঳࣮‫׳‬Ώ੔ਕ‫غ‬ਈ‫ܨ‬ೋබ͹ਏஇ๑ʀ࣑ྏ๑͹֋൅Ν ϭέοϱ͹֋൅೶ߨ͑ɽಝͶΠϩςύ΢Ϝʖබ೶΃͹Πϝϫ΢χ Ў ஁പ࣯ட੷Ν‫ݰ‬ঙͦ͠Ζ '1$ ϭέο ϱ͹ࣰ༽ԿΝਬ਒ͤΖɽ͠ΔͶɼଡ༹͵ਈ‫ܨ‬ೋබΏ༹ʓ͵‫ݬ‬ҾͶًҾͤΖ຦঩ਈ‫˗ ্֒ܨ‬೟எ঳ͳ $/6 Ͷ‫ڠ‬௪ͤΖ‫ݬ‬͹ Ͷͯ͏ͱɼϐφ͹೶ਈ‫ܧܨ‬͹մੵͳಊ෼ʀࡋ๖Ϡυϩ͹մੵͳΝ༧߻͢ͱ਒Όɼͨ͹බ Ҿ஁പ࣯ҡ৙Ν൅‫͢ݡ‬ɼබସΝմ໎࣮ ҾʀබସΝ໎Δ͖Ͷ͢ͱ࣑ྏ๑͹֋൅Ͷ݃;ͯ͜Ζɽ

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˗ͱΞ͖Ξ൅ࡠ‫ޛ‬͹‫ى‬Գ্֒ͳࡇ࡝ࡶࡢ⬻ࡢⓎ㐩 ࠕೖ͹ҫྏ͹਒ิͶ΍͖͖ΚΔͥɼ೶൅ୣ্֒͹൅ਫ਼ළౕͺ‫ݰ‬ঙ͢ͱ͕Δͥɼ߁൜੓ ͹ϟΩωθϞմ໎্൅ୣ্֒ʤࣙถ঳ʥΏ஭қܿ‫ؗ‬ଡಊ੓্֒ʤ$'+'ʥ͵ʹ͹೶൅ୣ্֒͹մ໎ͺɼঙࢢ ԿऀճΝ͓ܶͪೖຌͶ͕͏ͱͺ٦‫ە‬Ͷմ݀ͤ΄͘՟ୌͲ͍ΖɽΉͪɼঘࣉਈ‫׳࣮ܨ‬ͺɼ೶ ˗ೋ࣑੓ͱΞ͖Ξ͹घढ़ྏ๑֒ Ԏɼௗ‫ྏغ‬үΝ൒͑எద্֒ɼ೶੓ຓᙼɼ॑঳ৼਐ্֒ɼͱΞ͖Ξɼঘࣉ೶ञ ɼେःҡ ֋൅΃͹‫ر‬༫৙঳͵ʹଡ༹Ͳ͍Εɼ࣑ྏ๑΍಼Ռద࣑ྏ͖Δ೶֐Ռద࣑ྏΉͲଡ‫ز‬ͶΚͪΖ࣑͗ࠞద˗࢐ԿηφϪηͳ೶൅ୣ্࣑֒ྏ๑ͺཱི֮͢ͱ͏͵͏ɽ͞͹ͪΌɼ‫ؽ‬೵ժ଀దɼබସҫָదɼਏஇබཀྵָదɼਫ਼ཀྵָద ͹‫ܐؖ‬Νմ໎͵‫ڂݜ‬Νਬ਒͢ɼ৿ͪ͵࣑ྏ๑ʀϨύϑϨτʖεϥϱ๑͹֋൅Ν໪ࢨͤɽΉͪɼ೶͹‫ܙ‬੔ Ν੏‫ͤޜ‬ΖҪఽࢢ‫ؽ‬೵ΏɼͱΞ͖Ξ൅ࡠ͵ʹ͹‫׈‬ಊͶғଚద͵Ҫఽࢢʀ෾ࢢ‫ߑؽ‬͹մ໎ ˗ଽࣉ‫غ‬Ͷ೶͗Ͳ͘Ζ࢕ૌΊ͹ͪΌ͹‫ڂݜ‬Νߨ͏ɼַ৿ద͵ҫྏ͹֋൅Ν໪ࢨͤɽͶ৿ͪ͵൅‫ݡ‬

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ۢ෾͞ΗΉͲ͹‫ڂݜ‬੔Վյ ᚰࡢ⑓ࡢཎᅉ✲᫂ ֦झ͹੠ਈ্֒ʤ‫ـ‬෾্֒ɼ෈҈ʀηφϪη੓্֒ɼ౹߻ࣨ௒঳ɼ෼࣯ғଚɼਯເ্֒

˗౹߻ࣨ௒঳͹൅঳‫ݬ‬ҾҪఽ͵ʹʥͶଲ͢ͱɼҪఽָదʀ෾ࢢਫ਼෼ָదघ๑ͶΓΖ‫ݬ‬Ҿ‫ڂ‬໎͹ͪΌ͹‫ڂݜ‬Ν਒ఴͦ͠ ࢢ͹൅‫ྏ࣑;ٶݡ‬༂͹֋൅
Ζɽ֦බସͶ͕͏ͱɼҪఽࢢଡ‫ܗ‬ΏޫึҪఽࢢʀ‫ؖ‬࿊Ҫఽࢢ͹մੵɼࢰ‫ޛ‬೶Ώਫ਼ରࢾྋΝ ༽͏ͪਫ਼Կָదմੵɼਫ਼෼ָద੮ओ੓Ͷ‫ͤؖ‬Ζ෾ࢢʀࡋ๖Ϫϗϩ͹մੵɼҪఽࢢրรϜΤ ˗ҪఽࢢմੵͶΓΖ༂෼‫״‬णηΝ༽͏ͪߨಊϪϗϩ͹մੵ͵ʹͶΓΕɼ‫ݬ‬Ҿ‫ેخ;ٶ‬ϟΩωθϞΝմ໎ͤΖɽ͍Κͦ ੓༩଎๑͹֋൅ͱ೶ഀΏཱࣙਈ‫׈ܨ‬ಊ͵ʹ͹੠ਈਫ਼ཀྵָదࢨඬ͹෾ੵΏɼωϣʖϫ΢ϟʖζϱήघ๑Ͷ ˗գເ঳͹බସͶ‫ؖ‬༫ͤΖҪ
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ΏɼබସͶӪ‫ͤڻ‬Ζӭ཈ો͹‫ڂݜ‬ɼಊ෼ϠυϩͶΓΖޫึ࣑ྏ༂ඬద෾ࢢ͹ࡠ༽‫ؽ‬঄͹ఽࢢ͹൅‫ݡ‬մੵ͵ʹΝ௪ͣͱɼΨʖξʖϟ΢χ͹࣑ྏ๑Ώ༩๹๑͹ࣰ‫ݳ‬Ν໪ࢨͤɽն ᚰࡢ೺ᗣ࡙ࡃࡾ ঙࢢ߶ྺԿɼ‫ࡃܨ‬ΏชԿ͹ήϫʖώϩԿɼ৚ๅΏαϝϣωίʖεϥϱ͹ ,7 Կͺɼऀճ˗376' ਏ இ ऊ ౕ ͹ ֋ ൅ ͳ֒ ߑଆͳ‫ݺ‬ਕ͹қࣟΝร༲ͦ͠ɼՊఋɼ৮৖ɼָߏɼஏҮ͹‫ڧ؂‬Ͷ୉͘͵รԿΝ΍ͪΔ͢ͱ෕‫ٶ‬
͏ΖɽͨΗͶ‫ؖ‬࿊͢ͱਫ਼ͣΖηφϪηΏᷦ౽ͺɼ‫ݺ‬ਕ͹ϟϱνϩϖϩη෈௒Ͷͯ͵͗Ε Ώ͚ͤɼϟϱνϩίΠ͹ैࣰ͗චགྷͳ͠ΗΖɽ۫ରద໲ୌͳ͢ͱɼͪͳ͓ͻࣙࡶΏ͑ͯබ ˗ғ ଚ ঳ ਏ இ ऊ ౕ ͹ ֋ ൅ ͳ͹ଁՅɼະԈͤΖ༂෼ཛྷ༽ɼࣉಒࢧॡ‫غ‬͹෈నԢΏ໲ୌߨಊɼৼదφϧΤϜ͗΍ͪΔͤ ෕‫ٶ‬376' ‫ؖ‬࿊্֒ɼ࢚๑੠ਈҫָద՟ୌͳ͢ͱ͹Յ֒ߨಊ͹බཀྵ౵ͺɼ৿ͪ͵ϟϱνϩϖ ϩηϕϫϠʖεϥϱ͹͍Ε๏͹‫ڂݜ‬Ν‫ٽ‬Όͱ͏Ζɽͨ͹໪దͶ޴͜ͱɼΦϑυϱηΝ॑ ˗ࢧॡ‫غ‬Ͷ͕͜Ζ୉‫و‬ໝαϙࢻࣰͪ͢ৄద‫ڂݜ‬घ๑ͶΓΕɼӺָదࣰସɼްՎద͵࣑ྏʀղ೘Ώ༩๹‫گ‬үͶͯ͏ͱ໎Δʖφ‫ڂݜ‬͖Ͷ͢ɼ๮ΉΗΖ੏ౕΏ੕ࡨ͹ࣰ‫ݳ‬Ͷ΍‫ر‬༫ͤΖ͞ͳΝ໪ࢨͤɽշ ┳ㆤ㺃௓ㆤࢣ࢔࡜ࣜࣁࣅࣜ
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݊߃໲ୌΏೖ৙ਫ਼‫׈‬͹ࢩ্Νܲ‫ͤݰ‬Ζ͞ͳͺɼ্֒Ͷ‫͢ۦ‬΋ਕʓ͹̨̦̣ʤਫ਼‫׈‬͹࣯ʥ͹ ͹ཱི֮ͳ੏ౕԿ΃͹߫‫ݛ‬޴৏ͶͳͮͱචਤͲ͍Ζɽ͞͹‫ڂݜ‬՟ୌͲͺɼͨ͹໪దͶ޴͜ͱɼΓΕΓ͏؅‫ޤ‬ʀղ‫ ޤ‬๑ɼϨύϑϨ๑ɼେ଺๑Ώ؉࿪ίΠ๑͹֋൅Ν໪ࢨͤ‫ڂݜ‬Νਬ਒ͤΖɽ͵͖Ͳ΍ɼඉ৷ऽ ˗୉೶ൔ‫ځ‬ଝউ‫ޛ‬͹߶࣏೶‫ؽ‬దਕ޽‫ٷݼ‬๑ʤ1339ʥ͵ʹྏ཈ंͳղ‫ंޤ‬Ͷෝ୴͗ঙ͵͚҈સ͵؅‫ࢩޤ‬ԋ๑Ώࡑ୒ҫྏ؇ཀྵ๑͹֋൅ɼஏҮͲਫ਼‫׈‬ΝӨ΋্֒ं͹ऀճ෰‫ؾ‬ōऀճࢂՅ͹ࢩԋ͹ैࣰɼฯ݊ʀҫྏʀ೵্֒͹ਏஇ๑͹ཱི֮˗‫׈۔‬ಊ͹ఈྖదմੵͶΓΖෳࢳ͗࿊‫ͪ͢ܠ‬ඇ༽ଲްՎ͹߶͏γʖϑη఑‫ڛ‬ର੏͹ཱི֮͵ʹΝ໪ࢨͪ͢‫ڂݜ‬Νఴ֋ͤ ӣಊ‫ؽ‬೵඲Ճ๑͹֋൅
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՘ฆ঳ʀ‫ـ‬؇ࢩᄸଋʀΠφϒʖ੓ൿේԎͺɼ౐಼Ͳ΍‫਼ं׳‬͹ଡ͏࣮‫͍Ͳ׳‬ΖɽΉ˗ΠϪϩάʖϜΤη͹ࡠड़ɼͪɼԦธ‫ܗ‬͹ৱਫ਼‫׈‬ͶΓΖϟνϚϨρέ঳ޫ‫܊‬΍೧ʓ਄ࠃԿ͢ͱ͏Ζɽ͞͹Γ͑͵ΠϪ ͵Δ;ͶΠϪϩάʖ੻೜ࡋ๖
ϩάʖ੓࣮‫׳‬Ώਫ਼‫׈‬स‫׵‬බͺɼ7 ࡋ๖ɼ඄ຮࡋ๖ɼࢹ๳ࡋ๖౵͹௒ઇҡ৙ͶًҾͤΖͪ ͹൅‫ݡ‬ΌɼΉͥ੻೜ࡋ๖͹ଁ৫ʀ෾Կʀಊҽ͹෾ࢢ‫ߑؽ‬Ν໎Δ͖ͶͤΖචགྷ͍͗ΖɽҲ๏ɼ಼దགྷҾͶΓͮͱ͕͞Ζࣙ‫ހ‬໖Ӻ࣮‫׳‬ɼେःҡ৙ɼೋ࣑੓ଃ‫ح‬ร੓࣮‫׳‬͹ྭ΍ଡ͏ɽ͞Η˗՘ฆ঳Νܲ‫ͦ͠ݰ‬Ζ৿͢͏࣑ྏ๑͹‫ڂݜ‬ΔΝࠂෲͤΖͶͺɼഃ୾ͪ͢ࡋ๖‫ؽ‬೵ͳ੻೜෾ࢢͳΝಋఈ͢ɼ͞ΗΔΝ༂෼౦༫Ώࡋ๖ Ң৪ͶΓͮͱਜ਼৙Կͦ͠͵͜Ηͻ͵Δ͵͏ɽૌ৭‫ࡋײ‬๖Ώ L36 ࡋ๖Ν༽͏ͪ࠸ਫ਼ҫྏ๑ ˗඄ຮ੓౸೚බ͹ѳԿҾࢢί΍ߡྂ͠ΗΖ΄͘Ͳ͍Ζɽຌ‫ڂݜ‬՟ୌͲͺɼਫ਼ର๹‫ޜ‬͹ϟΩωθϞΝ‫ݺ‬ରʀࡋ๖ʀ෾ࢢ ϠΩ΢ϱ &;&/ ͹մ໎ϪϗϩͲ‫͢ڂݜ‬ɼͨΗΔ͹ഃ୾ͶًҾͤΖ֦झ࣮‫׳‬͹࣑ྏ๑ʀ༩๹๑͹֋൅Ν໪ࢨͤɽպ ⑌⑓ࡢ㑇ఏᏛ˗ඬదࡋ๖όρέΠΤφ

ຌ‫ڂݜ‬՟ୌͺɼϐφ͹࣮‫ͨͳ׳‬͹੻೜Ҫఽࢢͳ͹૮‫ܐؖޕ‬ΝҪఽָదघ๑ͶΓΕմ໎ ʤ75(&.ʥ๑ͶΓΖϐφ࣮‫׳‬͢ɼ࣮බ͹‫ݬ‬Ҿ‫ڂ‬໎ΏͨΗΝ‫ྏ࣑و৿ͪ͢ͳેخ‬๑͹֋൅Ͷͯ͵͝Ζ͞ͳΝ໪దͳ͢ͱ ϠυϩϜΤη͹ࡠड़
͏Ζɽ๏๑ͺҐԾ͹  ͯͲ͍Ζɽ୊  ͺɼϐφ࣮‫׳‬ɼ͍Ζ͏ͺϐφ࣮‫׳‬Ϡυϩಊ෼͹ଡ༹͵න‫ܗݳ‬ΝࢩഓͤΖ੻೜ҪఽࢢΝಋఈ͢ɼͨ͹Ҫఽࢢ͹ߑଆͳ‫ؽ‬೵͖Δɼබ‫ـ‬͹‫ݬ‬ҾΝ໎Δ͖Ͷ͢ͱ͏͚Ҫఽָద๏๑Ͳ͍Ζɽ୊  ͺޫึ੻೜ҪఽࢢΝ༽͏ͱҪఽࢢրรϜ઎
˗ϐφ࣮‫׳‬ϠυϩϜΤηΝ༽͏ͪೋ௎ɼപ಼্‫ݬ‬ҾҪఽࢢ͹‫ڂ‬໎ΤηΝࡠड़͢ɼಝఈ͹Ҫఽࢢ͹‫ؽ‬೵࣮͗බ൅঳ͳଲԢͤΖ͖ʹ͖͑Ν‫ͤৄݗ‬Ζ‫ٱ‬Ҫఽָ ˗ϝφαϱχϨΠබ‫ڂݜ‬͹ͪΌద๏๑Ͳ͍Ζɽ͞ΗΔ͹‫ڂݜ‬͹݃Վɼधཱི͠Ηͪϐφ࣮‫׳‬Ϡυϩಊ෼ͺɼ༙༽͵Ϩγʖ ͹ϝφαϱχϨΠՆࢻԿϜΤη୼ οςʖϩͳ͢ͱɼඬదͳ͵Ζ༹ʓ͵࣮බ͹࣑ྏ๑Ώ༩๹๑͹֋൅Ͷༀཱིͯɽ

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೶‫ײ‬ʀ੺ਹ͹ӣಊਈ‫֫ܨ‬ɼ຦঩ਈ‫ܨ‬ʀ‫۔‬ʥɼ͕Γ;‫ְ״‬εητϞʤࢻְʀ௎ְʀັְʀ

˗਷қӣಊ࣎Ͷ͕͜Ζ੺ਹ͹ᅁְʀର੓‫ְ״‬ʥΝεητϞϪϗϩ͖Δ෾ࢢϪϗϩΉͲ͹ଡ૜దʀ෵߻దΠϕϫʖοͲ ӣಊ੏‫ߑؽޜ‬͹մੵ‫͢ڂݜ‬ɼͨ͹‫ؽ‬೵্֒͹ࠂෲΝਦΖɽಝͶɼ୉೶ʷঘ೶ʷ‫خ‬ఊ֫࿊‫ؖ‬Ͷ͕͜Ζ৚ๅॴཀྵ‫ߑؽ‬Νմ໎ͤΖ‫ڂݜ‬Νਬ਒͢ɼӣಊࣨ௒Ν࣮ͪͤ͘‫׳‬ʤϏʖΫϱλϱබɼ੺ਹঘ೶ร੓
঳͵ʹʥͲ‫ݡ‬ΔΗΖӣಊεητϞҡ৙͹බସմ໎Ώ࣑ྏ๑֋൅Ν໪ࢨͤɽΉͪɼ೶݄؇

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ࡢᵓ㐀ࡸಶࠎࡢ㐣⛬࡟㛵୚ࡍࡿᅉᏊࡢኚ໬ࡣࠊࡀࢇ➼ࡢ⑌ zࢤࣀ࣒ࡢᏳᐃ࡞⥅ᢎ࣭⥔ᣢ࡟㛵୚ࡍࡿᅉᏊ
ᝈࡢཎᅉ࡜࡞ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࢤࣀ࣒⥔ᣢ࣭⥅ᢎ ࡸࢤࣀ࣒ୖࡢ≉Ṧᵓ㐀ࡢ⏕⌮ⓗព⩏ࢆゎ᫂ࡢせ࡜࡞ࡿࢤࣀ࣒」〇࡜ࡑࡢไᚚᶵᵓࠊཬࡧࢤࣀ࣒ࡢከᵝ ࡍࡿࠋ
࡞ᵓ㐀ࡸࡑࡢไᚚᅉᏊࡢ⏕⌮ⓗព⩏ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼ
zᚓࡽࢀࡿᇶ♏ⓗ࡞▱ぢ࡟ᇶ࡙ࡁࠊไࡀࢇࡢ᪂つデ᩿࣭἞⒪ᡓ␎ࢆᵓ⠏ࡍࡿࠋ
ࡾࠊࢤࣀ࣒ࡢኚ໬ࡀ⑌ᝈࡢⓎ⏕࡜࠸࠿࡟㛵ࢃࡿ࠿ࢆゎ᫂ࡋࠊ᪂つࡢデ᩿ࠊ἞⒪ἲࡢ㛤Ⓨ࡟ᛂ⏝ࡍࡿࡇ࡜ࢆ┠ᣦࡍࠋ ့ங㢮⑌ᝈࣔࢹࣝື≀ࡣ㑇ఏᏛ◊✲࡟ࡼࡗ࡚ከࡃࡢ⑌ᝈz့ங㢮ࣔࢹࣝື≀ࡢ฼⏝࡟ࡼࡗ࡚⑓ẼࡢⓎࡢཎᅉゎ᫂࡟㈉⊩ࡋ࡚ࡁࡓࠋࡋ࠿ࡋࠊ௒࡞࠾ከࡃࡢ⑌ᝈ࡟
⑕࡜㑇ఏᏊ␗ᖖ࡜ࡢ㛵ಀࢆゎ᫂ࡋࠊ㑇ఏᏊ㛵ಀࡉࢀ࡚࠸ࡿ㑇ఏⓗཎᅉࡣ༑ศゎ᫂ࡉࢀ࡚࠸࡞࠸ࠋࡇࢀ
デ᩿ࡸ⑓Ẽࡢண㜵࣭἞⒪࡟ᙺ❧ࡘ㑇ఏ᝟ሗࡽࡢࣔࢹࣝື≀ࡣ⑓ែ⌮ゎࠊ᪂⸆ホ౯ࡢࡓࡵ࡟ࡶᚲ㡲࡛࠶ࢆ⵳✚ࡍࡿࠋ
ࡾࠊࡑࡢ㛤Ⓨࡣ㔜せ࡞◊✲ㄢ㢟࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛
zࣄࢺࡢ⑓ែホ౯ࡸࠊ᪂ࡓ࡞⸆࣭ᶵ⬟ᛶ㣗ရࡣࠊゎᯒᅔ㞴࡞ࣄࢺࡢ⑌ᝈࡢ⑓ែゎ᫂࡟ᙺ❧ࡘࣔࢹࣝື≀ࡢ㛤Ⓨ࡬㈉⊩࡛ࡁࡿ့ங㢮ࣔࢹࣝື≀ࢆᶞࢆᶞ❧ࡋࠊ㡰㑇ఏᏛⓗゎᯒ࡟ࡼࡿࡇࢀࡽࡢⓎ⑕ཎᅉࡢゎ᫂❧ࡍࡿࠋࢆ┠ᣦࡍࠋ
Ꮨ⠇ᛶ࢖ࣥࣇ࢚ࣝࣥࢨࡣࠊẖᖺ⣙  ୓ேࡶࡢṚ⪅ࢆࡶࡓ΢ϱϓϩΦϱδ‫ ;ٶ‬% ‫ܗ‬ʀ& ‫ܗ‬،ԎΤ΢ ࡽࡋ࡚࠸ࡿࡇ࡜࡟ຍ࠼ࠊ⮴Ṛᛶࡀ㧗࠸᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ
ࡀࠊᮾி࡞࡝ࡢ㉸ேཱྀᐦ㞟ᆅ࡛ὶ⾜ࡋࡓሙྜ࡟ࡣࠊࡑࡢேzᏘ⠇ᛶ࢖ࣥࣇ࢚ࣝࣥࢨࠊ᪂ᆺ࢖ࣥࣇ࢚ࣝࣥ
ϩη‫״‬ઝ঳͹༩๹ͳ࣑ྏ
ⓗ࣭♫఍ⓗ⿕ᐖࡣ᝿ീࢆ⤯ࡍࡿࡶࡢ࡜࡞ࡿࠋࡲࡓࠊࢃࡀᅜ
ࢨࡢ⑓ែࢆゎ᫂ࡋࠊண㜵࣭἞⒪ἲࡢ㛤Ⓨࢆ࡛ࡣࠊ% ᆺ⫢⅖࢘࢖ࣝࢫࠊ& ᆺ⫢⅖࢘࢖ࣝࢫឤᰁࡀ⫢ࡀࢇ҈Ҭชඛ
┠ᣦࡍࠋⓎ⑕ཎᅉࡢ௨ୖࢆ༨ࡵ࡚࠾ࡾࠊᏳ඲࡛Ᏻ౯࡞἞⒪ἲࡢ‫״‬ઝ੏‫ޜ‬ϕϫζΥέφz% ᆺࠊ& ᆺ⫢⅖࢘࢖ࣝࢫឤᰁ⑕ࡢ⑓ែࢆゎ㛤Ⓨࡣ㔜せ࠿ࡘ⥭ᛴࡢ♫఍ⓗせㄳ࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ
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᫂ࡋࠊ἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ࢙ࢡࢺ࡛ࡣࠊ᪂ᆺࢆྵࡴࡍ࡭࡚ࡢ $ ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖
9LUDO,QIHFWLRXV'LVHDVHV3URMHFWࣝࢫ࡟᭷ຠ࡞࣡ࢡࢳࣥࡸ᪂ࡓ࡞἞⒪⸆ࡢ㛤Ⓨࢆ┠ᣦࡍ࡜࡜ࡶ࡟ࠊ࢘࢖ࣝࢫᛶ⫢⅖ࡢ἞⒪࣡ࢡࢳࣥࡢ㛤Ⓨࢆ┠ᣦࡍࠋ

Τ΢ϩη‫״‬ઝ͹ϟΩωθϞͶ‫࣑ͪ͏Ͱخ‬̒ព ⩏ᴣ౽ ࣰ ָस‫ى‬ԳϕϫζΥέφ
/HDUQLQJDQG0HPRU\3URMHFWᅜෆእ࡟࠾࠸࡚࢘࢖ࣝࢫࡢὶ⾜࡟ࡼࡾ೺ᗣ⿕ᐖࡸ♫఍ⓗ⤒῭ᦆኻࡀⓎ⏕ࡋ࡚࠸ࡿࠋ࢘࢖ࣝࢫࡣᐟ୺ࡢ୰࡛」〇ࡋ࡚z࢚ࣥࢸࣟ࢘࢖ࣝࢫ  ࡢ⑓ཎᛶࢆᨭ㓄ࡍࡿ⑓Ẽࢆᘬࡁ㉳ࡇࡍࡇ࡜࠿ࡽࠊ࢘࢖ࣝࢫഃ࡞ࡽࡧ࡟ᐟ୺ഃࡢ
࢘࢖ࣝࢫഃせᅉ࡜ᐟ୺ഃࡢせᅉࢆゎ᫂ࡍ୧᪉ࡢせᅉࢆゎᯒࡋࠊࡑࡢண㜵ࡸ἞⒪ࡢᑐ⟇ࢆ❧࡚ࡿࡇ࡜ࡿࠋࡀ㔜せ࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ㏆ᖺ࢔ࢪ࢔࡛኱ὶ⾜ࡀz࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢ 51$ ࣏࣓࣮ࣜࣛ
ぢࡽࢀ࡚࠸ࡿ࢚ࣥࢸࣟ࢘࢖ࣝࢫࠊ࡞ࡽࡧ࡟࢖ࣥࣇ࢚ࣝࣥࢨ
ࢮάᛶࢆ㜼ᐖࡍࡿᢠ࢖ࣥࣇ࢚ࣝࣥࢨ⸆ࡢ㛤࢘࢖ࣝࢫࢆྲྀࡾୖࡆࠊࡇࢀࡽࡢ࢘࢖ࣝࢫࡢ」〇ࡢ࣓࢝ࢽࢬ
Ⓨ➼ࢆ┠ᣦࡍࠋ
࣒ࢆ᫂ࡽ࠿࡟ࡋࠊ἞⒪⸆ࡢ㛤Ⓨ➼࡟ࡘ࡞ࡀࡿ◊✲ࢆᒎ㛤ࡍࡿࠋ㒔Ẹࡢ  ࡀࡾᝈࡋ࡚࠸ࡿࢫࢠⰼ⢊⑕ࡣࠊ᰿ᮏ἞⒪ἲ࡜
z࢔ࣞࣝࢠ࣮⑌ᝈࡢ⑓ែᙧᡂ࣓࢝ࢽࢬ࣒࡜ච
ࡋ࡚⯉ୗච␿⒪ἲࡀಖ㝤㐺⏝ࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽච␿⒪␿⒪ἲࡢస⏝࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋ
ἲࡣࠊ㹼 ๭⛬ᗘࡢே࡟ࡣຠᯝࡀ࡞࠸ࡓࡵࠊ࢔ࣞࣝࢠ࣮἞z⯉ୗච␿⒪ἲ࡟࠾ࡅࡿ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪⒪ࡣ౫↛࡜ࡋ࡚ᢠ࢔ࣞࣝࢠ࣮⸆➼ࡢᑐ⑕⒪ἲࡀ୰ᚰ࡛࠶
ࢆ☜❧ࡍࡿࠋ
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࢔ࣞࣝࢠ࣮ච␿⒪ἲࡢస⏝࣓࢝z⮫ᗋᛂ⏝࡛ࡁࡿ࢔ࣞࣝࢠ࣮᪂つ἞⒪ἲࡸ᪂ࢽࢬ࣒ࢆゎ᫂ࡋಶࠎࡢᝈ⪅࡟㐺ࡋࡓ᪤Ꮡ⒪ἲࡢᨵၿ࡜᪂つ⸆ࢆ㛤Ⓨࡍࡿࠋ⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ㧗㱋໬࡟ࡼࡿࡀࢇࡢቑຍ࡜ୡ⏺ⓗ࡞᪂⯆࣭෌⯆ឤᰁ⑕ࡢⓎ⏕ࡣࠊ⌧ᅾ኱ࡁ࡞♫఍ၥ㢟࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡ zࡀࢇ࣭ឤᰁ⑕ࢆ୰ᚰ࡜ࡋࡓศᏊᶆⓗࡢ᥈⣴ࢺ࡛ࡣࠊࡇࢀࡽࡢၥ㢟ࢆඞ᭹ࡍࡿࡓࡵ࡟ࠊࡀࢇࠊឤᰁ⑕ࢆ ࡜ゎᯒࢆ㐍ࡵࠊศᏊᶆⓗ࡟ࡼࡿデ᩿࣭἞⒪୰ᚰ࡟ࡋࡓ᪂つศᏊᶆⓗࡢ᥈⣴࡜ゎ᫂࡟ࡼࡿᇶ♏◊✲ࢆ᥎ ἲࢆ㛤Ⓨࡍࡿࠋ㐍ࡍࡿࠋ࠶ࢃࡏ࡚ࠊ⏘ᐁᏛ་㐃ᦠࡸ㒔❧⑓㝔➼࡜ࡢᶫΏࡋ z⏘ᐁᏛ་㐃ᦠ࡟ࡼࡿᶫΏࡋ◊✲ࢆ᥎㐍ࡍ◊✲ࢆ㐍ࡵ࡚ࠊḟୡ௦ࡢデ᩿ἲࡸᶵჾࠊ᪂ࡋ࠸἞⒪ἲ㛤Ⓨ ࡿࠋ࡞࡝ࡢᐇ⏝໬ࢆ┠ᣦࡍࠋ㤳㒔ᮾி࡟࠾࠸࡚ࡣ㉸㧗㱋໬ࡀ㐍ࡳࠊㄆ▱⑕ᑐ⟇ࡣᛴົ z๗᳨⬻ࡢ⚄⤒⑓⌮ࠊ⏕໬Ꮫゎᯒࢆ⾜࠸ࠊศ࡛࠶ࡿࠋᚎࠎ࡟⑓ែࡀ㐍⾜ࡍࡿ࢔ࣝࢶࣁ࢖࣐࣮⑓ࠊࣞࣅ࣮ Ꮚ⑓ែࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ᑠయᆺㄆ▱⑕ࠊ๓㢌ഃ㢌ⴥኚᛶ⑕࡞࡝ࡢㄆ▱⑕⑌ᝈ࡟ࡘ࠸ zᝈ⪅⑓ኚࢆ෌⌧ࡍࡿヨ㦂⟶ࠊ⣽⬊ࠊື≀࡚ࣔࡣࠊ᰿ᮏ἞⒪ἲࡣᮍࡔ࡟࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊゎ ࢹࣝࢆᵓ⠏ࡋࠊ⑓ែ㐍⾜ࢆᢚไࡍࡿ⸆๣ࡸ
᫂ࡉࢀ࡚࠸࡞࠸⬻ࡢ␗ᖖ⑓ኚࡢゎᯒࢆ㐍ࡵࠊ⑓ែࢆ෌⌧ࡍ ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋࡿヨ㦂⟶ࠊ⣽⬊ࠊື≀ࣔࢹࣝࢆᵓ⠏ࡋࠊ⑓ែ㐍⾜ࢆᢚ࠼ࡿ zᮏࣉࣟࢪ࢙ࢡࢺࢳ࣮࣒ࡀᥦၐࡋࡓఏ᧛௬ㄝ
ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋ
⸆๣ࡸ἞⒪ἲࡢ㛤Ⓨࢆ┠ᶆ࡜ࡍࡿࠋ
zࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹ࡛ࣝᏛ⩦グ᠈ࢆᢸ࠺Ꮫ⩦グ᠈ࡣ⢭⚄άືࡢᇶ┙࡜࡞ࡿ㔜せ࡞⬻㧗ḟᶵ⬟࡛࠶㑇ఏᏊࢆྠᐃࡋࠊ᭱᪂ࡢ࢖࣓࣮ࢪࣥࢢ࣭ග
ࡾࠊ㐺ṇ࡞Ꮫ⩦グ᠈ຊࡢ⥔ᣢࡣ⏕άࡢ㉁ࡢ⥔ᣢ࡟ᚲせ࡛࠶᧯సᢏ⾡࡟ࡼࡾグ᠈㐣⛬ࡢྍど໬࡟ᣮࡴࠋ
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻ࡀ࡝ࡢࡼ࠺࡟ࡋ࡚ᚲせ࡞᝟ሗzࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹࣝ࠿ࡽᚓࡽࢀࡓ▱ぢࢆグ᠈ࡋ࡚ಖᣢࡋࠊᚲせ࡟ᛂࡌ࡚ㄞࡳฟࡍࡢ࠿ࢆࠊグ᠈ࢆࢆ့ங㢮ࣔࢹ᳨࡛ࣝドࡍࡿࡇ࡜࡟ࡼࡾᏛ⩦ᢸ࠺⚄⤒ᅇ㊰࡜ศᏊ⤒㊰ࡢാࡁ࠿ࡽ᫂ࡽ࠿࡟ࡍࡿࠋ࠶ࢃࡏ
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࡚ྛ✀⢭⚄⚄⤒⑌ᝈࡸຍ㱋࡟ࡼࡾ⌧ࢀࡿグ᠈㞀ᐖࡢཎᅉࢆ
zࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹࣝ࡜့ங㢮ࣔࢹ࡛ࣝศᏊ࣭ᅇ㊰࡛ࣞ࣋ࣝ᥈ࡾࠊࡑࡢᑐ⟇࡟㈨ࡍࡿᇶ┙᝟ሗࢆᥦࡢ┦⿵ⓗゎᯒ࠿ࡽྛ✀グ᠈㞀ᐖ⑓ែࡢศᏊ
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࢙ࢡࢺ࡛ࡣࠊ୙἞ࡢ⑓࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ⬻⬨㧊ᦆയzయᛶឤぬᶵ⬟ࡢ෌ᘓࢆᐇ⌧ࡍࡿேᕤ⚄⤒᥋ᝈ⪅ࡢ㝶ព㐠ືᶵ⬟࡜యᛶឤぬᶵ⬟ࢆྲྀࡾᡠࡍ㠉᪂ⓗ࡞἞⥆ἲࢆ㛤Ⓨࡋࠊࡑࡢ᭷ຠᛶࢆ᳨ドࡍࡿࠋ⒪ἲࢆ㛤Ⓨࡋࠊ⬻⬨㧊ᦆയ࡟ࡼࡗ࡚ኻࡗࡓᶵ⬟࡛࠶ࡿ͆⮬zᚰ࡜㌟యࢆ⧅ࡄ⚄⤒ᇶ┙ࢆゎ᫂ࡋࠊࡑࢀ࡟
ศࡢ㌟యࢆឤࡌࠊ⮬ศ࡛ື࠿ࡍ͆ࡇ࡜ࢆ෌⋓ᚓࡍࡿࡇ࡜ࢆ
ᇶ࡙࠸ࡓᶵ⬟ᅇ᚟ಁ㐍ἲࢆ㛤Ⓨࡍࡿࠋ┠ᣦࡍࠋzⓎ㐩ᮇࡢ⬻ෆ⎔ቃࡢ⥔ᣢࡢࡓࡵ࡟㸪⚄⤒⣽ࡇ࡝ࡶࡢ⬻࡟ࡣ኱ேࡢ⬻࡟ࡣぢࡽࢀ࡞࠸⚄⤒⣽⬊ࡢࡳ࡞ ⬊ࡸࢢࣜ࢔⣽⬊ࡀྖࡿ⚄⤒ච␿ࡢᙺ๭ࢆゎࡽࡎࢢࣜ࢔⣽⬊ࡢᵝࠎ࡞ാࡁࡀ࠶ࡿࠋ⬻ࡀⓎ㐩ࡍࡿࡓࡵ࡟ ᫂ࡍࡿࠋ
ࡣࠊࡇࢀࡽࡢႠࡳࡀṇᖖ࡟ไᚚࡉࢀࡿᚲせࡀ࠶ࡿࠋᮏࣉࣟ zࡇ࡝ࡶࡢ⬻࡟࠾ࡅࡿ⬻ෆ⎔ቃ⥔ᣢࡢࡓࡵࡢ
ࠦ‫ʹ͞ ܔؔٳ‬΍͹೶ϕϫζΥέφࢪ࢙ࢡࢺ࡛ࡣࠊ୺࡟ච␿⣔ࡢどⅬ࠿ࡽࠊⓎ㐩ᮇࡢ⬻ෆ⎔ቃ ච␿⣔࡜㠀ච␿⣔ࡢࢿࢵࢺ࣮࣡ࢡࢆゎ᫂ࡍࢆ⥔ᣢࡍࡿࡓࡵࡢ௙⤌ࡳ࡜ࠊࡑࡢ◚ࡓࢇ࡟ࡼࡿ⬻⅖࣭⬻⑕ ࡿࠋ࡞࡝ࠊࡇ࡝ࡶࡢ⬻⑌ᝈࡢཎᅉࢆゎ᫂ࡋࠊண㜵ἲࠊ἞⒪ἲࡢ zࡇ࡝ࡶࡢ⬻⑌ᝈ࡟࠾ࡅࡿ⬻⅖࣭⬻⑕࡞࡝ࡢ'HYHORSPHQWDO1HXURLPPXQRORJ\3URMHFWⓎ⑕ᶵᗎࢆゎ᫂ࡋ㸪᪂ࡓ࡞ண㜵ἲࠊ἞⒪ἲ㛤Ⓨࢆ┠ᣦࡍࠋ
ࡢ㛤Ⓨࢆ┠ᣦࡍࠋ
͞ʹ΍͹೶Ͷ͕͜Ζ‫ڧ؂‬ң࣍‫ߑؽ‬͹մ໎εψϕηՆા੓͹ҡ৙ͳ࣮‫׳‬ࢃ‫ܙ‬གྷਕ εψϕηՆા੓ϕϫζΥέφ
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6FKL]RSKUHQLD5HVHDUFK3URMHFWࢩࢼࣉࢫࡣ⚄⤒⣽⬊ྠኈࡢ᝟ሗఏ㐩㒊࡛࠶ࡾࠊእ࠿ࡽࡢ
ࢫࢺࣞࢫ࡟㐺ᛂࡋ࡚ኚ໬ࡍࡿᛶ㉁㸦ࢩࢼࣉࢫྍረᛶ㸧ࢆಖzࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼࡿ㞴἞ᛶ࡚ࢇ࠿
ࡕ࡞ࡀࡽᶵ⬟ࡋ࡚࠸ࡿࠋከࡃࡢ⢭⚄࣭⚄⤒⑌ᝈ࡟࠾࠸࡚ࡣ
ࢇࠊ▱ⓗ㞀ᐖ➼ࡢⓎ⑕ᶵᵓゎ᫂࡜἞⒪ἲ㛤ࢩࢼࣉࢫࡢ␗ᖖࡀᣦ᦬ࡉࢀ࡚࠸ࡿࡀࠊࡑࡢ඲ㇺࡣ᫂ࡽ࠿࡛
Ⓨࢆ┠ᣦࡍࠋ
ࡣ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼ
zࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼࡿ⮬㛢⑕ࡢⓎ⑕ࡗ࡚⏕ࡌࡿ㞴἞ᛶ࡚ࢇ࠿ࢇࡸ▱ⓗ㞀ᐖࠊ⮬㛢⑕࡞࡝ࡢ⑌ᝈ
ᶵᵓゎ᫂࡜἞⒪ἲ㛤Ⓨࢆ┠ᣦࡍࠋࣔࢹࣝື≀ࢆస〇ࡋࠊࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿ
ࡇ࡜࡟ࡼࡾࠊ᪂ࡋ࠸ண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ⚄⤒⣽⬊࡟ᡂ㛗ࡍࡿ๓ࡢ⚄⤒๓㥑⣽⬊࡜ࠊࡑࢀࡽ࠿ࡽ⏕ࡲࢀࡓ⚄⤒⣽⬊ࡀᡂ⇍ࡋ࡚⏕ࡁᘏࡧ࡚ࡺࡃ㐣⛬㸦ศ໬࣭⏕z⚄⤒⣽⬊ࡢศ໬࣭⏕ᏑࢆྖࡿศᏊ࣓࢝ࢽࢬ
Ꮡ㸧ࢆไᚚࡍࡿᅉᏊ࡟ࡣࠊ⢭⚄Ⓨ㐩㐜⁫ࠊຍ㱋ᛶ⬻㞀ᐖࡸ࣒➼ࢆ◊✲ࡋࠊ᪂ࡓ࡞⬻ࡢⓎ㐩ࡸᶵ⬟⥔ᣢ⬻⭘⒆ࡢⓎ⏕࡟㛵୚ࡍࡿࡶࡢࡀ࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛
ࡢᶵᵓࢆゎ᫂ࡍࡿࠋ
ࡣࠊ⚄⤒⣽⬊ࡢศ໬࣭⏕ᏑࢆྖࡿศᏊ࣓࢝ࢽࢬ࣒ࡸ⎔ቃᅉzୖグࡢᶵᵓࡢ◚ࡓࢇ࡟ࡼࡿ㞴἞ᛶ⬻⚄⤒⑌Ꮚࡢᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋࠊ⬻ࡢⓎ㐩ࡸᶵ⬟⥔ᣢࡢᶵᵓࢆゎ᫂ᝈࡢண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋࡋࠊࡑࢀࡽࡢ㞀ᐖ࡟ࡼࡿ㞴἞ᛶࡢ⬻⚄⤒⑌ᝈࢆඞ᭹ࡍࡿ἞⒪ἲࠊண㜵ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋⓎ㐩㐣⛬࡟࠾ࡅࡿ⬻ࡢ୰࡛᪂ࡓ࡟ㄌ⏕ࡋࡓ⚄⤒⣽⬊ࡣࠊ⬻ෆࢆ⛣ືࡋ࡞ࡀࡽ⚄⤒✺㉳ࢆ㐺ษ࡟ఙ㛗ࡋ࡚⚄⤒ᅇ㊰ࢆ z⚄⤒⣽⬊ࡢⓎ㐩ᮇ࡟࠾ࡅࡿ⛣ືࠊ⚄⤒✺㉳ᙧᡂࡍࡿࠋࡇࢀࡽࡢ⚄⤒ᅇ㊰ᙧᡂ࡟␗ᖖࡀ⏕ࡌࡿ࡜ࠊ⬻ᙧ ᙧᡂ࡞࡝࡟ࡼࡿ⚄⤒ᅇ㊰ᙧᡂࡢศᏊ࣓࢝ࢽ
ࢬ࣒ࢆゎ᫂ࡍࡿࠋ
ᡂ␗ᖖ࡞࡝ᵝࠎ࡞⚄⤒⑌ᝈࡢཎᅉ࡟࡞ࡿ࡜⪃࠼ࡽࢀ࡚࠸
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⚄⤒ᅇ㊰ᙧᡂࢆไᚚࡍࡿ⣽⬊እ z⚄⤒ᅇ㊰ᙧᡂ␗ᖖ࡟ࡼࡗ࡚⏕ࡌࡿ⢭⚄࣭⚄ࡢ⎔ቃᅉᏊࡢᶵ⬟࡟㛵ࡍࡿศᏊᶵᵓࡸࠊ⯆ዧᛶ࡜ᢚไᛶࡢ ⤒⑌ᝈࡢ⑓ᅉゎ᫂࡜἞⒪ἲࡢ㛤Ⓨ࡟ᐤ୚ࡍ⚄⤒⣽⬊ࡢ⛣ື࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡾࠊ⢭⚄࣭ ࡿࠋ⚄⤒⑌ᝈࡢ᪂ࡋ࠸ண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ⌧௦ࢫࢺࣞࢫ♫఍ࡢ⦰ᅗ࡜࠸࠼ࡿ኱㒔ᕷ࡛ࡣࠊᚰࡢ೺ᗣ zᛮ᫓ᮇࡢ࣓ࣥࢱࣝ࣊ࣝࢫၥ㢟ࡢண㜵せᅉࡸࢆ⼃ࡴࡉࡲࡊࡲ࡞せᅉࡀ⁄ࢀࡿ୍᪉ࠊಶேࢆᨭ࠼ࡿேࠎࡢ ࢙࢘ࣝࣅ࣮࢖ࣥࢢቑ㐍せᅉࢆ᫂ࡽ࠿࡟ࡍ
⤎ࡣⷧࡲࡗ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞୰࡛⮫ᗋ་Ꮫ࣭♫఍་Ꮫⓗ ࡿࠋ᪉ἲㄽ࡟ࡼࡾᚰࡢ೺ᗣ࡙ࡃࡾ◊✲ࡢከ㠃ⓗ࡞᥎㐍ࡀồࡵࡽ zᆅᇦ࡛ᬽࡽࡍㄆ▱⑕ࡢே࡜ᐙ᪘࡬ࡢࢣ࢔ࢆ
ࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊᑡᏊ㧗㱋໬ࡀ㐍ࡴᮾி࡟ ྥୖࡉࡏࡿࠋ
࠾࠸࡚༊࣭ᕷ࡜㐃ᦠࡋࡓ኱つᶍฟ⏕ࢥ࣮࣍ࢺ◊✲ࡢᐇドⓗ z⢭⚄⑌ᝈࡢᛴᛶᮇධ㝔་⒪࡜㏥㝔ᚋእ᮶་ᡂᯝࡸ⮫ᗋ࣭ࢣ࢔⌧ሙ࡜ࡢ༠ാ࡟ࡼࡿࣉࣟࢢ࣒ࣛ㛤Ⓨ➼ࢆ ⒪࡜ࢆ⤖ࡪ⛣⾜ᮇᨭ᥼ࣉࣟࢢ࣒ࣛࢆ㛤Ⓨࡍࡿࠋ
㏻ࡌࠊ኱㒔ᕷࡢᚰࡢ೺ᗣ࡙ࡃࡾ࡟ྲྀࡾ⤌ࡴࠋ⤫ྜኻㄪ⑕ࡣᝈ⪅࡜ᐙ᪘ࡢᬽࡽࡋ࡜೺ᗣ࡟኱ࡁ࡞ᙳ㡪ࢆz⤫ྜኻㄪ⑕ࡢデ᩿἞⒪࡟ᙺ❧ࡘࣂ࢖࣐࣮࢜
ཬࡰࡍᚰࡢ⑓࡛࠶ࡾࠊᝈ⪅ᩘࡣ  ୓ே࡟࠾ࡼࡪࠋ࡯࡜ࢇ
࣮࢝ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
࡝ࡢᝈ⪅ࡣ  ௦࠿ࡽ  ௦࡟Ⓨ⑕ࡋࠊࡑࡢᚋ㛗ᮇ㛫ࡢ἞⒪z㒔❧⑓㝔࡜㐃ᦠࡋ࡚᪩ᮇデ᩿ἲࡢ㛤Ⓨࢆ┠ࢆవ൤࡞ࡃࡉࢀࡿࡀࠊ᰿ᮏⓗ࡞ཎᅉࡣ࠸ࡲࡔ୙࡛᫂ᑐ⑕⒪ᣦࡍࠋἲⓗ἞⒪ࡀ⾜ࢃࢀ࡚࠸ࡿࡢࡀ⌧≧࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺz⤫ྜኻㄪ⑕ࡢཎᅉࢆゎ᫂ࡋ᪂ࡓ࡞ண㜵࣭἞࡛ࡣࠊ⚄⤒⛉Ꮫⓗᡭἲ࡟ࡼࡾ⤫ྜኻㄪ⑕ࡢཎᅉ✲᫂ࢆ㐍⒪ἲࢆ㛤Ⓨࡍࡿࠋ
ࡵࠊࡼࡾ᭷ຠ࡞ண㜵࣭἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ࠺ࡘ⑓࡞࡝Ẽศ㞀ᐖࡣ㏆ᖺᝈ⪅ᩘࡀቑຍࡋ࡚࠾ࡾࠊ⮬ẅz࠺ࡘ⑓ື≀ࣔࢹࣝࢆ☜❧ࡍࡿ࡜࡜ࡶ࡟ࠊ࢜
͑ͯබ͹‫ݬ‬Ҿ‫ڂ‬໎ͳਏஇʀ࣑ྏ๑͹֋൅ ࡢ୺せཎᅉ࡜࡞ࡿ࡞࡝ࠊࡑࡢ♫఍㈇ᢸࡣ㔜࠸ࠋ⑓ែࡀᮍࡔ
ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࡞࡝⬻⣽⬊࡛ࣞ࣋ࣝࡢ
୙࡛᫂ᐈほⓗデ᩿ἲࡶ࡞ࡃࠊ἞⒪ἲࡶ༑ศ࡛ࡣ࡞࠸ࠋᮏࣉ
ゎᯒࢆ㐍ࡵࠊẼศ㞀ᐖࡢ⑓ែゎ᫂ࢆ⾜࡞ࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻ࡢ␗ᖖ㒊఩ࡢྠᐃ࠾ࡼࡧࡑࢀ࡟ᇶ࡙ࡃ
࠺ࠋ㒖ྜྷٝ޻ ͑ͯබϕϫζΥέφᐈほⓗデ᩿ἲࡢ㛤Ⓨࢆ⾜࠺࡜࡜ࡶ࡟ࠊ࠺ࡘ⑓ື≀ࣔࢹࣝ⣔zᇶ♏࡜⮫ᗋࡢᶫΏࡋ◊✲ࢆ୰ᚰ࡟⾜࠸ࠊ⏬
ࡸ⚄⤒̾ࢢࣜ࢔┦㛵ࠊ≉࡟࢜ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࡞࡝⬻⣽ീࡸ⾑୰ࣂ࢖࣐࣮࣮࢜࢝࡞࡝ᐈほⓗデ᩿ἲ⬊ࣞ࣋ࣝࡢࣔࢹࣝ⣔ࡢゎᯒࢆ㏻ࡋ࡚ࡼࡾ๪స⏝ࡢᑡ࡞࠸἞
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8ELTXLWLQ3URMHFW‫ࡋײ‬๖Νཤ༽݄ͪ͢ӹ࠸ਫ਼ҫྏٗढ़ͳ͗
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⌧௦♫఍࡛ࡣኪᆺ໬࡜▷᫬㛫╧╀໬ࡀ㐍⾜ࡋࠊປാࡢ
㉁ⓗኚ໬ࡶ࠶ࡗ࡚៏ᛶⓗ࡞╧╀㞀ᐖࢆッ࠼ࡿேࡀቑ࠼࡚
࠸ࡿࠋ╧╀㞀ᐖࡢ᭱኱ࡢၥ㢟ࡣ╀Ẽ࡟క࠺᪥ᖖ⏕άୖࡢᨭ㞀࡛࠶ࡿࠋࡲࡓ୰㏵ぬ㓰ࡣຍ㱋➼࡟కࡗ࡚ከࡃࡳࡽࢀ
ࡿࡀ᭷ຠ࡞἞⒪ἲࡀ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ㐣╀⑕≧ࡸ╧╀ศ᩿໬⑕≧ࢆ࿊ࡍࡿ╧╀㞀ᐖࡢ⑓ែࢆゎ᫂ࡋࠊ᪩ᮇデ᩿࣭἞⒪ຠᯝุᐃ࡟౑࠺ࣂ࢖࣐࣮࣮࢜࢝ࡸ᪂つ἞⒪⸆ࡢ㛤Ⓨࢆ┠ᣦࡍࠋz㐣╀ࢆ࿊ࡍࡿ╧╀㞀ᐖࡢ⑓ែࢆゎ᫂ࡋࠊデ᩿࣭ண㜵࣭἞⒪ἲࢆ㛤Ⓨࡍࡿࠋz╧╀⥔ᣢᏳᐃ໬స⏝ࢆᣢࡘ≀㉁ࡢዌຌᇶ┙ࢆゎ᫂ࡋࠊ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋzぬ㓰ไᚚࡢᇶ┙ࢆ⣽⬊࣭ື≀ࣔࢹ࡛ࣝㄪ
࡭ࠊ೺ᗣⓗ࡞╧╀ࡢ᮲௳ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

౫Ꮡᛶ⸆≀ࡣࠊ῝้࡞♫఍ၥ㢟࡛࠶ࡿ⸆≀౫Ꮡࡸᗁぬ࣭ዶ᝿ࡢཎᅉ࡛࠶ࡿ୍᪉ࠊ⑊③ࡸⓎ㐩㞀ᐖ࡞࡝ࡢ἞⒪⸆࡜ࡋ࡚ᗈࡃ⏝࠸ࡽࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ౫
Ꮡᛶ⸆≀ࡢస⏝ᶵᗎࢆゎ᫂ࡋࠊࡑࡢᡂᯝࢆ་⒪ᛂ⏝ࡍࡿࡓࡵࡢ◊✲ࢆ㐍ࡵࡿࡇ࡜࡛ࠊ౫Ꮡ⑕࡞࡝ࡢ᪂ࡓ࡞἞⒪ἲࡸண㜵ἲࢆ㛤Ⓨࡋࠊࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ἲ࡞࡝ࡢ⑊
③⟶⌮ᢏ⾡ࡢྥୖࡸࠊὀពḞዴከືᛶ㞀ᐖ㸦$'+' ࡸ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ࡞࡝ࡢⓎ㐩㞀ᐖࡢ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋz౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎ࡟ᇶ࡙ࡃ౫Ꮡ⑕࡞࡝
ࡢ἞⒪ἲ࠾ࡼࡧண㜵ἲࢆ㛤Ⓨࡍࡿࠋzಶࠎேࡢ㑇ఏᏊ࡟ྜࡗࡓ᪩ᮇ࠿ࡽࡢ㐺ษ࡞⑊③἞⒪ἲࡢᨵⰋ࡜㐺ᛂᣑ኱ࢆ┠ᣦࡍࠋz$'+'ࠊ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ࡞࡝ࡢⓎ㐩㞀ᐖࡢ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ࢝ࣝࣃ࢖ࣥࡣࠊᵝࠎ࡞⣽⬊ෆ⺮ⓑ㉁ࢆษ᩿ࡋ࡚ᶵ⬟ࡸᵓ㐀ࢆኚ᥮ࡍࡿࡇ࡜࡟ࡼࡾࠊ⣽⬊ࢆࠊࡦ࠸࡚ࡣ⏕యࢆㄪ⠇ࡋ࡚࠸ࡿ㓝⣲࡛࠶ࡿࠋࡑࡢࡓࡵࠊ࢝ࣝࣃ࢖ࣥࡀ࠺ࡲࡃ
ാ࠿࡞ࡃ࡞ࡿ࡜➽ࢪࢫࢺࣟࣇ࢕࣮ࡸ⫶ฟ⾑࡞࡝ࠊᵝࠎ࡞
⑌ᝈࡀⓎ⑕ࡍࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࢝ࣝࣃ࢖ࣥࡀ࡝
ࡢࡼ࠺࡟⣽⬊ࡢാࡁࢆㄪ⠇ࡋ࡚࠸ࡿࡢ࠿ࠊศᏊࡢࣞ࣋ࣝ
࡛ゎᯒࡋࠊࡇࢀࡽࡢ⑌ᝈࡀⓎ⑕ࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜࡛ࠊ⑌ᝈࡢデ᩿ࡸ἞⒪ࡢ᪉ྥᛶࢆ♧ࡍࠋz࢝ࣝࣃ࢖ࣥࡢస⏝ᶵᗎࢆศᏊ࡛ࣞ࣋ࣝゎᯒࡋࠊࡑࡢ⏕⌮ᶵ⬟ࢆ᫂☜࡟ࡍࡿࠋ
z࢝ࣝࣃ࢖ࣥ࡞࡝ࡢ㑇ఏᏊᨵኚ࣐࢘ࢫࢆ⑌ᝈ
ࣔࢹࣝ࡜ࡋ࡚ࠊⓎ⑕ᶵᵓࢆゎᯒࡍࡿࠋ
z࢝ࣝࣃ࢖ࣥ୙඲⑌ᝈ࡛ࡢ㛵㐃ศᏊࡢኚ໬ࢆ
ゎᯒࡋࠊࡑࡢデ᩿࣭἞⒪ࡢ᪉ྥᛶࢆ♧ࡍࠋࣘࣅ࢟ࢳࣥࡣ⣽⬊ෆ࡟࠾࠸࡚ࠊࡉࡲࡊࡲ࡞⺮ⓑ㉁ࡸ⣽⬊ᑠჾᐁࡢ⏕Ṛࢆྖࡾࠊࡑࢀࡽࡢ㐠࿨ࢆỴᐃ௜ࡅࡿᅉᏊ
࡛࠶ࡿࠋ㏆ᖺࠊࣘࣅ࢟ࢳࣥࡢ␗ᖖࡣࠊࣃ࣮࢟ࣥࢯࣥ⑓ࢆ
ࡣࡌࡵ࡜ࡍࡿᵝࠎ࡞⑌ᝈ࡜ᐦ᥋࡟㛵ಀࡍࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊㅦ࡟ໟࡲࢀࡓࣘࣅ࢟ࢳ
ࣥࡢ⏕యෆ࡟࠾ࡅࡿᙺ๭ࢆゎ᫂ࡍࡿ࡜࡜ࡶ࡟ࠊࣃ࣮࢟ࣥ
ࢯࣥ⑓࡞࡝ࡢ⚄⤒ኚᛶ⑌ᝈ࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

zࣘࣅ࢟ࢳࣥ࡟╔┠ࡋ࡞ࡀࡽࠊࣃ࣮࢟ࣥࢯࣥ
⑓࡞࡝ࡢ⚄⤒ኚᛶ⑌ᝈࡢⓎ⑕ᶵᵓ࡟㏕ࡿࠋz⏕యෆࡢࣘࣅ࢟ࢳࣥ⎔ቃࢆᨵኚࡋ࡚ࠊ⑓Ẽࡢࣔࢹࣝື≀ࢆస〇ࡍࡿࠋz⏕యෆ࡛ᵝࠎ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࣘࣅ࢟ࢳ
ࣥࡢᶵ⬟ࢆ᫂ࡽ࠿࡟ࡋ࡚ࠊࣄࢺࡢ೺ᗣ⥔ᣢ࡟ᙺ❧࡚ࡿࠋ

㐀⾑ᖿ⣽⬊ࡣࠊ⮚ჾ࡟⾑ࢆ㏦ࡾฟࡋࠊࡀࢇࡸឤᰁ⑕࡜
ᡓ࠺ච␿⣽⬊ࢆ⏘ࡳฟࡋ࡚ࡃࢀࡿࠊ⏕య࡟࡜ࡗ࡚ᚲ㡲࡞⣽⬊࡛࠶ࡿࠋ㧗㱋໬♫఍ࢆ㏄࠼ࡓࢃࡀᅜ࡛ࡣࠊ㦵㧊⛣᳜
ࡸ㍺⾑ࡢࢯ࣮ࢫࢆ☜ಖࡍࡿ᪂ࡋ࠸་⒪ᢏ⾡ࡢ㛤Ⓨࡀồࡵࡽࢀ࡚࠸ࡿࠋࡲࡓࠊࡀࢇ⣽⬊ࡢቑṪ࡜㌿⛣࡟ࡣࠊ㐀⾑ᖿ⣽⬊࡜ඹ㏻ࡢศᏊࡀ౑ࢃࢀ࡚࠸ࡿࡇ࡜ࡀุ᫂ࡋࡓࠋᮏࣉ
ࣟࢪ࢙ࢡࢺ࡛ࡣࠊL36 ⣽⬊࠿ࡽ㐀⾑ᖿ⣽⬊࣭⾑ᑠᯈ࣭ච␿⣽⬊ࢆຠ⋡ⓗ࡟సࡾฟࡍ᪉ἲࠊࡑࡋ࡚ᖿ⣽⬊㑇ఏᏊࢆᶆⓗ࡜ࡋࡓ᪂ࡋ࠸ࡀࢇ἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋzL36 ⣽⬊ࡢヨ㦂⟶ෆᇵ㣴࡟ࡼࡗ࡚ࠊ㐀⾑ᖿ⣽⬊࣭⾑ᑠᯈ࣭ච␿⣽⬊ࢆຠ⋡ⓗ࡟సࡾฟࡍ᪉ἲࢆ㛤Ⓨࡍࡿࠋzᛴᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚ࠼ࡿࠊ
᪂ࡋ࠸ࡀࢇ἞⒪⸆ࡢ㛤Ⓨࢆ┠ᣦࡍࠋzࡀࢇࡢ㌿⛣࡟౑ࢃࢀࡿศᏊࢆᶆⓗ࡜ࡋࡓࠊ᪂ࡋ࠸ᢠࡀࢇ๣ࡢ㛤Ⓨࢆ┠ᣦࡍࠋ

L36 ⣽⬊࡟ࡣᵝࠎ࡞་⒪ᛂ⏝ࡀᮇᚅࡉࢀࠊ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࡀࠊࡑࡢࢤࣀ࣒ࢆ᧯సࡍࡿࡇ࡜ࡢᅔ㞴ࡉࡀ㧗࠸㞀ቨ࡜࡞ࡗ࡚ࡁࡓࠋࡋ࠿ࡋࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓎᒎ࡟ࡼࡾࠊࡑࡢ㞀ቨࡶྲྀࡾᡶࢃࢀࡘࡘ࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ
࡛ࡣࠊL36 ⣽⬊࡜ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜
࡛ࠊ㑇ఏᛶ⑌ᝈࣔࢹࣝస〇࡟ࡼࡿ⑌ᝈࡢⓎ⑕ᶵᗎࡢゎᯒࠊ࠾ࡼࡧ⑌ᝈࡢཎᅉ࡜࡞ࡿኚ␗ࢆಟṇࡋࡓ L36 ⣽⬊࡟ࡼࡿ⣽⬊⛣᳜἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋz೺ᗣ࡞ே⏤᮶ࡢ L36 ⣽⬊࡟⑌ᝈࡢཎᅉ࡜࡞
ࡿኚ␗ࢆᑟධࡍࡿࡇ࡜࡛ࠊ⑌ᝈࢆ෌⌧ࡋࡑ
ࡢⓎ⑕ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿࠋzᝈ⪅⏤᮶ࡢ L36 ⣽⬊ࡢኚ␗ࢆṇᖖ࡞ '1$ 㓄ิ࡟ಟṇࡋࠊ⣽⬊ࡢᶵ⬟ࢆᅇ᚟ࡉࡏ࡚⛣᳜἞⒪ࢆ⾜࠺ࡓࡵࡢᢏ⾡ࢆ㛤Ⓨࡍࡿࠋ᪥ᮏࡣ㧗㱋໬♫఍ࢆ㏄࠼ࠊ⬻༞୰ࡢᝈ⪅ᩘࡀቑຍࡋ࡚
࠸ࡿࠋ⬻༞୰ᚋࡢ㯞⑷ࡸ⬻ᶵ⬟ࡢ㞀ᐖࡣࠊᝈ⪅ࡢ♫఍᚟ᖐ࡟኱ࡁ࡞ᨭ㞀࡜࡞ࡗ࡚࠸ࡿࡀࠊ⬻༞୰࡟ᑐࡍࡿ᭷ຠ࡞
἞⒪ἲࡣࡲࡔ༑ศ࡟㛤Ⓨࡉࢀ࡚࠸࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ
࡛ࡣࠊ⬻༞୰ᝈ⪅ࡢ♫఍᚟ᖐࢆಁࡍࡼ࠺࡞᪂ࡋ࠸἞⒪ἲࢆ㛤Ⓨࡍࡿࡓࡵ࡟ࠊᦆയࡋࡓ⬻ࡀ࡝ࡢࡼ࠺࡟ᅇ᚟ࡍࡿ࠿
ࢆヲ⣽࡟ゎ᫂ࡍࡿࠋ᭱㏆࡟࡞ࡗ࡚ච␿Ꮫࡸ⚄⤒⛉Ꮫࡢ᪂ࡋ࠸◊✲ᡭἲࡀὀ┠ࢆᾎࡧ࡚࠾ࡾࠊࡇࢀࡽࢆᛂ⏝ࡍࡿࡇ࡜࡟ࡼࡗ࡚⬻༞୰◊✲ࢆ᪂ࡋ࠸ゅᗘ࠿ࡽⓎᒎࡉࡏࠊ⬻༞୰ᚋࡢ⬻ࡢ෌⏕ࠊᝈ⪅ࡢ♫఍࡬ࡢ᚟άࢆ୺┠ᶆ࡜ࡋ࡚◊✲ࢆ⾜࠺ࠋz⬻༞୰ࢆ㉳ࡇࡋࡓ⬻ෆ࡛సࡽࢀࡿࢱࣥࣃࢡ
㉁ࡸ⬡㉁ࠊపศᏊ໬ྜ≀࡟╔┠ࡋ࡚ࡑࢀࡽ
ࡢᶵ⬟ࡸ⏕⌮ⓗព⩏ࢆゎ᫂ࡋࠊ᪂ࡋ࠸⬻༞
୰ࡢ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋz⬻᱾ሰࡸㄆ▱⑕࡛ࡣ⬻ෆ࡟⅖⑕ࡀ㉳ࡇࡿ
ࡀࠊ⅖⑕ࢆ㉳ࡇࡍཎᅉ≀㉁ࢆ⬻ෆ࠿ࡽ᤼㝖ࡍࡿ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋࠊࡇࢀࢆ᪂ࡋ࠸἞⒪ἲࡢ㛤Ⓨ࡟ᛂ⏝ࡍࡿࠋz⬻༞୰ࢆ㉳ࡇࡋࡓᚋࡢ⬻ෆ࡛ࡣࠊቯࢀࡓ⚄⤒ࢿࢵࢺ࣮࣡ࢡࡀ෌ᙧᡂࡉࢀࡿࡀࠊࡇࡢ࣓
࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡗ࡚ࠊ⬻༞୰ᝈ⪅ࡢᶵ⬟ணᚋࢆᨵၿࡍࡿ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡿࠋ

⬻༞୰࣭ࣃ࣮࢟ࣥࢯࣥ⑓࣭⬨㧊ᑠ⬻ኚᛶ⑕࡞࡝࡛ࡣࠊ
኱⬻⓶㉁ࠊᇶᗏ᰾ࠊᑠ⬻ࡀ」ྜⓗ࡟㞀ᐖࡉࢀࡿࡓࡵࠊࡑ
ࡢ⑓ែࡣ」㞧࠿ࡘከᵝ࡛࠶ࡿࠋࡑࡢ⤖ᯝࠊ⑓ែࡢᮏ㉁ࡀ
୙㏱࡛᫂࠶ࡾࠊ἞⒪ࡢ⌧≧ࡣᑐ⑕ⓗ࡟␃ࡲࡿࠋᮏࣉࣟࢪ
࢙ࢡࢺ࡛ࡣࠊ ࡘࡢ㐠ື୰ᯡࡢసືཎ⌮ࢆゎ᫂ࡋࠊࡑࡢ
ᡂᯝࢆ㋃ࡲ࠼࡚ࠊ⚄⤒⑌ᝈ࡟࠾ࡅࡿ」㞧࡞⑓ែࢆᐈほⓗ࡞ࣃ࣓࣮ࣛࢱ࡟ኚ᥮ࡋࠊ἞⒪࡟ࣇ࢕࣮ࢻࣂࢵࢡࡍࡿࢩࢫ
ࢸ࣒ࢆ㛤Ⓨࡍࡿ࡞࡝ࠊ」ྜⓗ◊✲ࢆ᥎㐍ࡍࡿࠋz኱⬻࣭ᇶᗏ᰾࣭ᑠ⬻ࡢ㐠ືไᚚ࡟࠾ࡅࡿᶵ
⬟㐃ᦠࢆゎ᫂ࡍࡿࠋ
zከᵝ࡞㐠ື㞀ᐖࡢ⑓ែࢆศᯒ࣭ྍど໬ࡍࡿ࢔ࣝࢦࣜࢬ࣒ࢆ㛤Ⓨࡍࡿࠋz⚄⤒⑌ᝈࡢ἞⒪ࢆ࢞࢖ࢻࡍࡿ⚄⤒⑌ᝈ἞⒪ࢼࣅࢤ࣮ࢱ࣮ࡢᐇ⏝໬ࢆ┠ᣦࡍࠋ

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ቑຍࡍࡿどぬ㞀☀⪅ࡢ⏕άࡢ㉁㸦42/㸧ྥୖࢆᅗࡿࡓࡵ
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ࡾࠊᏳ඲࡞⒪㣴⎔ቃ࣭ᨭ᥼ࢩࢫࢸ࣒ࡢ඘ᐇ
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ᴫせ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡᅜෆእࡢ◊✲≧ἣᰁⰍయࡢ」〇•⤌᥮࠼•ಟ᚟➼ࡢ◊✲ࡣࠊ✀ࠎࡢ⏕≀✀࡛㐍ࢇ࡛࠸ࡿࠋ」〇㛤ጞࡢ㓝⣲Ꮫⓗ◊✲ࡣฟⱆ㓝ẕࡢ⣔࡛ᅜእ࡛ᛴ㏿࡟㐍⾜ࡋ࡚࠸ࡿࠋᡃࠎࡣ」〇ࣉࣟࢢ࣒ࣛࡢไᚚᅉᏊࢆୡ⏺࡟ඛ㥑ࡅ࡚ྠᐃࡋࡓࠋ᭦࡟ࠊ」〇㛤ጞ࡜ࣉࣟࢢ
࣒ࣛไᚚ࡟࠾࠸࡚ࠊG4ࡀᴟࡵ࡚㔜せ࡞ᙺ๭ࢆᯝࡓࡍ஦ࢆⓎぢࡋࡓࠋཪࠊ⣽⳦࠿ࡽࣄࢺࡲ࡛ಖᏑࡉࢀࡓᬑ㐢ⓗ࡞」〇㛤ጞᶵᵓ࡟G4ࡀ㛵୚ࡍࡿྍ⬟ᛶࢆᣦ᦬
ࡋࡓࠋG4ࡢᶵ⬟࡟ࡘ࠸࡚ࡣ⥆ࠎ࡜᪂ࡋ࠸Ⓨぢࡀࡉࢀ࡚࠾ࡾࠊ௒ᚋ┈ࠎከࡃࡢ▱ぢࡀ㞟✚ࡉࢀࡿ࡛࠶ࢁ࠺ࠋཪG4ࢆᶆⓗ࡜ࡋࡓ๰⸆ࡶෆእ࡛㐍⾜ࡋ࡚࠸ࡿࠋ
ࡋ࠿ࡋࠊG4ࡢࢤࣀ࣒ᶵ⬟ไᚚ࡟࠾ࡅࡿᙺ๭ࡢ඲యീ࡜ඹ࡟ࠊ⣽⬊ෆ࡛ࡢᏑᅾ
ᵝᘧࠊࡑࡢᙧᡂࡀ࠸࠿࡟ไᚚࡉࢀࡿ࠿࡜࠸࠺᰿ᮏⓗ࡞ၥ㢟ࡀᮍゎỴ࡛࠶ࡿࠋ(3)

Yang et al. (2019) E-life, 8. pii: e50796.; Ito, S. et al. (2019) Scientific Reports, 9(1), 18622; Masai, H. et al.
(2019), Scientific Reports, 9(1), 8618; Kobayashi, S. et al. (2019) Mol. Cell. Biol. pii: e00364-18.; Masai, H.
et al., J. Biol. Chem. 293, 17033; Moriyama et al. (2018) J. Biol. Chem. 293, 3607; Irie et al. Eur. J. Med.
Chem. 130, 406; Moriyama et al. (2017) Adv Exp Med Biol 1042, 287; Masai et al. (2017) Curr. Genet. 45,
6494; Masai, H. (2017) Cell Cycle 6, 735; You et al. (2017) NAR 45,6495; Matsumoto et al. (2017) MCB 37.
pii: e00355-16; Toteva et al. (2017) PNAS 114, 1093; Yang et al. (2016) Nature Communications 7:12135(2016); You et al. (2016) Cell Cycle 15, 1213; Tanaka et al. (2016) J. Biol. Chem. 291, 6316; e0132595;
Iguchi et al. (2015) J. Immunol. 195, 982; Kanoh et al. (2015) Nature Struct. Mol. Biol. 22, 889; Masai et al
Cold Spring Harbor Laboratory Meeting EUKARYOTIC DNA REPLICATION& GENOME
MAINTENANCE September 3̽7, 2019, Cold Spring Harbor, New York, USA; Masai et al. EMBO
Workshop on Fission Yeast/ The 10th International Meeting July 14-19, 2019 Barcelona, Spain; ṇ஭ஂ㞝,࣮࣡ࢡࢩࣙࢵࣉࠗᰁⰍయDNA」〇◊✲ࡢࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔࠘ ➨42ᅇ ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019ᖺ
12᭶3~6᪥, ⚟ᒸ; ṇ஭ஂ㞝,ࢩ࣏ࣥࢪ࣒࢘ࠗ᪂ࡋ࠸ࢤࣀ࣒ࡢጼ࡜ࡑࡢ⥔ᣢᶵᵓࡢࣇࣞ࢟ࢩࣅࣜࢸ࢕࠘
➨92ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019ᖺ9᭶18~20᪥,ᶓ὾;ṇ஭ஂ㞝, ⇃ᮏ኱Ꮫ࢚ࣜࢰࣥࣛ࣎◊✲఍㸭࣮ࣜࢹ࢕ࣥࢢࣉࣟࢢ࣒ࣛ㸸HIGO᭱ඛ➃◊✲ࢭ࣑ࢼ࣮;Masai et al. ➨41ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵ ࣉ ࠗ 㠀 ᶆ ‽ ᆺ ᰾ 㓟 ᙧ ែ ࡢ ⏕ ⌮ ࣭ ⑓ ⌮ ࡜ ࡑ ࡢ ไ ᚚ ࠘ 2018.11.28 㹼 11.30; Masai et al. 3R&3C
Symposium, November 12㹼16, 2018, Kanazawa, Japan; ṇ஭ஂ㞝ࡽ ➨91ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࢘ ࣒ 2018.9.25 ி 㒔 ᗓ ; ṇ ஭ ஂ㞝 ࡽ ⏕ ࿨ ⛉ Ꮫ ⣔ Ꮫ ఍ ྜྠ ᖺ ḟ ኱ ఍ 㸦 ConBio2017 㸧 2017 ᖺ 12᭶ 6᪥ ;Masai et al. CSH Meeting Cold Spring Harbor Laboratory, New York, USA, September 5-9, 2017; Cold
Spring Harbor Asia conference on DNA Metabolism, Genomic Stability and Human Disease,June 13-17,
2016,China;ṇ஭ஂ㞝 ᪥ᮏ㐍໬Ꮫ఍ ➨18ᅇᮾி኱఍࣮࣡ࢡࢩࣙࢵࣉ,2016ᖺ8᭶27᪥,ᮾிᕤᴗ኱Ꮫ኱
ᒸᒣ࢟ࣕࣥࣃࢫ㸦ᮾி㸧;ṇ஭ஂ㞝ࡽ, ➨89ᅇ ᪥ᮏ⏕໬Ꮫ఍኱఍, 2016ᖺ9᭶26᪥, ௝ྎ㸦ᐑᇛ㸧; ṇ஭ஂ㞝ࡽ,➨75ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ࢩ࣏ࣥࢪ࣒࢘ࠊ2016ᖺ10᭶8᪥ࠊᶓ὾㸦⚄ዉᕝ㸧;ṇ஭ஂ㞝ࡽࠊ➨ 39 ᅇ ᪥ ᮏ ศ Ꮚ ⏕ ≀ Ꮫ ఍ ᖺ ఍ ࢩ ࣥ ࣏ ࢪ ࢘ ࣒ ,2016ᖺ 12 ᭶ 2᪥ , ᶓ ὾ 㸦 ⚄ ዉ ᕝ 㸧 ;Masai et al.,10th 3R
Symposium Nov 13-17, 2017 Organizer; Cold Spring Harbor Meeting EUKARYOTIC DNA REPLICATION& GENOME MAINTENANCE Sept 1-5, 2015, New York USA

(2)

ᡂᯝࡢᴫせ

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Rif1-G4」ྜయࡢศᏊᙧែࢆCryo㟁㢧࠾ࡼࡧX⥺⤖ᬗᵓ㐀ゎᯒ࡟ࡼࡾࡉࡽ࡟ヲ⣽࡟ゎᯒࡍࡿࠋ
࣭ Rif1ࡢC➃ࢆ௓ࡋࡓ᰾⭷࡜ࡢ┦஫స⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ Rif1Cᮎኚ␗࡟ࡼࡿ᰾⭷⛣⾜ࡢ㞀ᐖࡀDSBಟ᚟ࠊ⤌᥮࠼ࠊ㌿෗࡞࡝࡟ཬࡰࡍ
ᙳ㡪ࡢゎ᫂ࠋ
࣭ G4ᵓ㐀ࡢᙧᡂࡀࢾࢡࣞ࢜ࢯ࣮࣒ᵓ㐀ࢆ㝖እࡍࡿᶵᵓࡢゎ᫂ࠋ࣭ G4/RNA-DNA hybrid౫ᏑⓗDNA」〇㛤ጞࡢ↷᫂ࠋ࣭ ⾑Ύ㣚㣹ࠊ㧗 ࠊᾐ㏱ᅽࠊ㓟໬࡞࡝✀ࠎࡢ⏕యࢫࢺࣞࢫ࡟ࡼࡿ」〇㞀ᐖㄏᑟ࠶ࡿ࠸ࡣChk1άᛶ໬ࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ ClaspinࡢศᏊෆ┦஫స⏝࡟ࡼࡿάᛶไᚚࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ Cdc7ཬࡧASKࡀࠊ⬻⚄⤒ࡸࠊ⾑⌫⣔⣽⬊Ⓨ⏕ࢆไᚚࡍࡿ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ Cdc7ཬࡧClaspinKO࣐࢘ࢫࠋMEFࢆ฼⏝ࡋࠊࡀࢇ⣽⬊Ṛㄏᑟࡢ᪂ࡋ࠸ᡓ␎ࢆ
⟇ᐃࡍࡿࠋ࣭ (1)࡛⤂௓ࡋࡓ᪉ἲࢆ⏝࠸ࠊ⣽⬊ෆ࡛ࡢG4ᙧᡂ࡟ᙳ㡪ࢆ୚࠼ࡿᅉᏊ(⣽⬊࿘ᮇࠊ࢚ࣆࢤࣀ࣒ࠊ㌿෗ࠊ㗪ᆺࡢ㉸ࡽࡏࢇᵓ㐀࡞࡝)ࢆỴᐃࡍࡿࠋ࣭ ࡑࡢ࡯࠿G4ࡸRNA-DNA hybridᵓ㐀ࢆ⣽⬊ෆ᳨࡛ฟࡍࡿ᪂ࡓ࡞ࣉ࣮ࣟࣈࢆ㛤Ⓨࡍࡿ࡜࡜ࡶ࡟ࠊG4⣽⬊ෆືែࢆほᐹࡍࡿࠋ(2)࣭ ศ⿣㓝ẕRif1ࡢᵓ㐀࣭ᶵ⬟ࡢヲ⣽࡞ゎᯒ࠿ࡽࠊRif1ࡢG4⤖ྜ⬟࡜ከ㔞యᙧᡂ⬟ࡢ୧⪅ࡀ」〇ᢚไ࡟ᚲせ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ(Moriyama et al. JBC; Kobayashi
et al. MCB)ࠋ
࣭ G4ᵓ㐀ࡣ1ᮏ㙐࣮ࣝࣉࢆ᭷ࡍࡿࡇ࡜ࢆ฼⏝ࡋ࡚ࠊไ㝈㓝⣲ࢆ⏝࠸࡚⣽⬊ෆG4ࢆ᳨ฟࡍࡿ᪂つᢏἲࢆ㛤Ⓨࡋࡓ(ᢞ✏୰)ࠋ
࣭ Rif1ࡢCᮎ➃ࡢ㝈ᐃࡉࢀࡓ࢔࣑ࣀ㓟ࡀࠊ᰾⭷࡬ࡢᒁᅾࠊᰁⰍయ㧗ḟᵓ㐀ࡢᙧᡂ࠾ࡼࡧ」〇ࢱ࢖࣑ࣥࢢࡢไᚚ࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ(ᢞ✏‽ഛ୰)ࠋ
࣭ Rif1ࡢ᰾⭷ᒁᅾ࡟ࠊࣃ࣑ࣝࢺ࢖ࣝ໬ࡀ㛵୚ࡍࡿࡇ࡜ࢆ♧ࡍdataࢆᚓࡓࠋ࣭ Rif1ቑ⏘ࡣࠊSᮇ㐍⾜㜼ᐖࢆ♧ࡍ࡜ඹ࡟ࠊMᮇࢆshort spindle࡛arrestࡉࡏࡿࠋ࣭ ཎ᰾⣽⬊ࡢRNaseHḞᦆୗ࡛ほᐹࡉࢀࡿ➨஧ࡢ」〇⣔࡟Gࡢ㐃⥆㓄ิࡀᚲせ࡛࠶ࡿࡇ࡜ࢆin vitro」〇⣔ࢆ⏝࠸࡚♧ࡋࡓࠋ࣭ Cdc7ࡣCK1(࢝ࢮ࢖ࣥ࢟ࢼ࣮ࢮ)࡜࡜ࡶ࡟ࠊClaspinࡢ」〇ࢫࢺࣞࢫ౫Ꮡⓗࣜࣥ㓟໬ࢆ௓ࡋ࡚」〇ࢫࢺࣞࢫㄏᑟࢆไᚚࡍࡿ(Yang et al. E-life)ࠋ
࣭ ࡀࢇ⣽⬊࡜ṇᖖ⣽⬊࡛ࡣ」〇ࢫࢺࣞࢫࢳ࢙ࢵࢡ࣏࢖ࣥࢺάᛶ໬࡟␗࡞ࡿ࢟ࢼ
࣮ࢮࢆ฼⏝ࡍࡿࡇ࡜ࢆ♧ࡋࡓ(Yang et al. E-life)ࠋ
࣭ ᗘኚ໬ࠊ㓟໬ࠊప㓟⣲ࠊᾐ㏱ᅽࠊᰤ㣴※ࠊ⣽⳦ឤᰁ࡞࡝✀ࠎࡢ⏕యࢫࢺࣞࢫ࡟ࡼࡾࠊClaspin౫Ꮡⓗ࡟Chk1ࡀάᛶ໬ࡉࢀࡿ஦ࠊᐇ㝿࡟」〇㞀ᐖࡀ⏕ࡌ࡚࠸ࡿ஦ࡀ᫂ࡽ࠿࡞ࡗࡓࠋࡇࢀࡣ⒴໬ࡢࣉࣟࢭࢫ࡟኱ࡁ࡞♧၀ࢆ୚࠼ࡿࠋ
࣭ Cdc7ࡣAuroraBࢆࣜࣥ㓟໬ࡋࠊάᛶ໬ࡋࠊMᮇึᮇࡢ㐍⾜ཬࡧࢫࣆࣥࢻࣝ㐍⾜ࢳ࢙ࢵࢡ࣏࢖ࣥࢺ࡟㛵୚ࡍࡿ(Ito et al. Sci Rep.)ࠋ

(1)

E

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A

ඹྠ◊✲⪅
ᑠ㔝ᐩ⏨㸦㑇ఏᏊᨵኚ㸧㐍⸨┿⏤⨾㸦⺮ⓑゎᯒᐊ㸧୸ᒣ༓⛅㸦⚄⤒ᅇ㊰ᙧᡂ㸧㛗⃝࿴ኵ㸦ᮾி㎰ᕤ኱㸧
Huilin Li㸦Van Andel ResearchInstitute㸧⚄⏣኱㍜㸦஑ᕞ኱Ꮫ㸧(2) ◊✲⪅ྡ
㧗஭⿱Ꮚ
ྜྷἑ┤Ꮚ
ᯇᮏΎ἞
᳃ᒣ㈼἞
⏣୰ ༟
ຍ⣡ ㇏
஭ཱྀᬛᘯ
ఀ⸨ࡉࡺࡾ
Chi-Chun Yang

E

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2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ṇ஭ஂ㞝㸧㸦◊✲௦⾲⪅ྡ㸧◊  ✲  ෆ  ᐜࡀࢇ࡞࡝ࡢ⑌ᝈ࡟㛵㐃ࡍࡿࢤࣀ࣒ᵓ㐀ࡢከᵝᛶ࡜⥅ᢎ࣭⥔ᣢࡢศᏊᶵᵓ㸭ࢤࣀ࣒ືែࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊✲ㄢ㢟ྡᡃࠎࡣࠊᰁⰍయࡢ」〇ࢆ୰ᚰ࡟ࢤࣀ࣒ࡢᏳᐃ࡞⥔ᣢ࡜ఏ᧛࡟㛵୚ࡍࡿࢤࣀ
࣒ไᚚ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࢆ┠ᣦࡋ࡚࠸ࡿࠋࡇࡢࡓࡵ࡟ࠊᰁⰍయ」〇ࢆไᚚࡍࡿࢤࣀ࣒㡿ᇦࢆྠᐃࡋࠊ㌿෗࡟ࡼࡾᙧᡂࡉࢀࡿࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀࡟౫Ꮡࡍࡿ」〇㛤ጞࡢᬑ㐢ⓗᶵᵓࡢゎᯒࢆ㐍ࡵࡓࠋࡲࡓࠊᰁⰍయ࡜᰾⭷ࡢ┦஫స⏝࡜ࠊᰁⰍయࢻ࣓࢖ࣥࡢᙧᡂ࡟ࡼࡿ」〇࣭⤌᥮࠼࣭㌿෗ࡢ᪂つไᚚᶵᵓࢆᥦၐ
ࡋࡓࠋ」〇ࢳ࢙ࢵࢡ࣏࢖ࣥࢺάᛶ໬࡟࠾ࡅࡿClaspinࡢไᚚᶵᵓࢆゎ᫂ࡋࠊࡀࢇ⣽⬊࡜ṇᖖ⣽⬊࡟࠾ࡅࡿ」〇ไᚚᶵᵓࡢ㐪࠸ࢆⓎぢࡋࠊࡑࢀ࡟ࡼࡿ᪂つไࡀࢇᡓ␎ࢆᥦၐࡋࡓࠋ

(1)୺࡞◊✲ᡂᯝ 

－ 10 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࡢ㑇ఏᏛⓗゎᯒࡣ⑌ᝈཎᅉ㑇ఏᏊࡢྠᐃ
࡟኱ࡁࡃ㈉⊩ࡋ࡚ࡁࡓࠋࡲࡓࠊࡑࡢᇶ┙࡜࡞ࡿࢤࣀ࣒᝟ሗࡣ
ᩚഛࡉࢀࠊࢤࣀ࣒ゎᯒᢏ⾡ࠊ㑇ఏᏊⓎ⌧ゎᯒᢏ⾡࠾ࡼࡧ㑇ఏᏊᨵኚ࣭ࢤࣀ࣒⦅㞟ᢏ⾡ࡶᛴ㏿࡟㐍Ṍࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊ」ᩘࡢ㔞ⓗᙧ㉁㑇ఏᏊᗙࡀ⤡ࡳྜࡗ࡚Ⓨ⑕ࡍࡿከᅉᏊ⑌ᝈ࡟࠾
࠸࡚ࡣࠊ⎔ቃせᅉࡢᙳ㡪ࢆཷࡅࡿࡇ࡜ࠊཎᅉ࡜࡞ࡿከᆺࡀ㠀ࢥ࣮ࢻ㡿ᇦ࡟Ꮡᅾࡍࡿࡇ࡜࠿ࡽ㑇ఏⓗせᅉࡢྠᐃࡀ࠸ࡲࡔ࡟
ᅔ㞴࡞≧ἣ࡛࠶ࡾࠊᅜෆእࡢከࡃࡢ◊✲⪅ࡀࣄࢺ࠾ࡼࡧࣔࢹ
࣐ࣝ࢘ࢫ࡟࠾࠸࡚㑇ఏᏛⓗゎᯒࡢࡓࡵࡢᢏ⾡㠉᪂࠾ࡼࡧ⌮ㄽᵓ⠏࡟ດࡵ࡚࠸ࡿࠋ  ᅜෆእࡢ◊✲≧ἣ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
࣭Hear Res
࣭Exp Anim
࣭Exp Anim࣭ឤぬ◊✲ࢥࣥࢯ࣮ࢩ࢔࣒୺ദ࣭➨୍ᅇឤぬ◊✲ࢩ࣏ࣥࢪ࣒࢘ ᮾி࣭➨ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ ᒣᙧ

ࣄࢺ⑌ᝈⓎ⑕࡜㑇ఏᏊኚ␗࡜ࡢ㛵㐃ࡣ㞴἞ᛶ⑌ᝈࢆ୰ᚰ࡟
ゎ᫂ࡉࢀࡘࡘ࠶ࡿࡀࠊ⎔ቃᅉᏊ࡜」ᩘࡢ㑇ఏᅉᏊࡢຠᯝ࡟ࡼ
ࡗ࡚Ⓨ⑕ࡍࡿࠕ࠶ࡾࡩࢀࡓ⑌ᝈࠖ࡟࠾ࡅࡿᐇド౛ࡣᴟࡵ࡚ᑡ
࡞࠸ࠋࡇࡢ≧ἣࢆᡴ㛤ࡍࡿࡓࡵ࡟ࡣࠊ⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࢆᇶ
┙࡜ࡋࡓ㡰㑇ఏᏛⓗ◊✲ࡀ᭷ຠ࡜࡞ࡿࠋຍ࠼࡚ࠊ࣐࢘ࢫࢆ⏝࠸ࡓ㏫㑇ఏᏛⓗ◊✲ࡣࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓏሙ࡟ࡼࡾຠ⋡ⓗ࡞⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࡢస〇ࡀྍ⬟࡜࡞ࡗࡓࠋࡑࡇ࡛ᮏ◊✲ࡣ࣐࢘ࢫ㑇ఏᏛࡢ୧㍯࡛࠶ࡿ㡰࣭㏫㑇ఏᏛࢆᇶ┙࡜ࡋࠊ୺࡟⫈ぬ⑌ᝈࢆᶆⓗ࡜ࡋࡓ⑌ᝈⓎ⑕ཎᅉ࣭㛵㐃㑇ఏᏊࡢྠᐃ࠾ࡼࡧ
⑌ᝈⓎ⑕ᶵᗎゎ᫂࡟᭷⏝࡞ࣔࢹ࣐ࣝ࢘ࢫࡢᶞ❧ࢆ┠ⓗ࡟◊✲ࢆᒎ㛤ࡍࡿࠋ  ᴫせ୺࡞◊✲ᡂᯝ 

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ᐑᆏຬ㍤
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ࣝࡀᏑᅾࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊ)ಶయ⩌ࡢ㡰㑇ఏᏛⓗゎᯒࡢ⤖ᯝࠊ) ಶయ⩌ࡢ⫈ຊࡣ;ᰁⰍయࡢࢭࣥࢺ࣓ࣟ࢔࠿ࡽ⣙0E㡿ᇦࡢ㑇ఏᏊᆺ࡜㐃㙐ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ  ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼
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࣭ள⣔⤫㛫࣐ࢵࣆࣥࢢ࠾ࡼࡧࢤࣀ࣒⦅㞟࡟ࡼࡗ࡚%$/%F⣔⤫ࡢ;ᰁⰍయୖࡢ㞴⫈ཎᅉ㑇ఏᏊࢆྠᐃࡍࡿࠋ◊       ✲       ᡂ       ᯝ ့ங㢮㑇ఏᏛࢆᇶ┙࡜ࡋࡓ㞴⫈➼ឤぬჾ⑌ᝈࡢⓎ⑕ᶵᵓࡢゎ᫂㸭့ங㢮㑇ఏࣉࣟࢪ࢙ࢡࢺ
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－ 11 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

࣭ +&9ㄏ Ⓨ ᛶ ⫢⥺ ⥔ ⑕ ࣔ ࢹ࣐ࣝ ࢘ ࢫ ࡟ ຍ࠼ࠊ ࢥ ࣜ ࣥ Ḟஈ㣗 ࡟ ࡼ ࡾ ㄏⓎࡋ ࡓ◊        ✲       ᡂ       ᯝ ࣄࢺ࡬ᛂ⏝ྍ⬟࡞⫢◳ኚ἞⒪⸆ࡢ㛤Ⓨࡀᚲ㡲࡛࠶ࡿࠋ἞⒪⸆ೃ⿵ࡀ」ᩘሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊఱࢀࡶ⥺⥔໬ᢚไᶵᗎࢆᶆ   ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭⫢⥺⥔⑕἞⒪⸆ೃ⿵35,ࡀ♧ࡍస⏝ᶵᗎࡢࡼࡾヲ⣽࡞ゎ᫂ࢆ┠ᣦࡍࠋ&ᆺⓗ࡜ࡋ࡚࠸ࡿⅭࠊ᰿ᮏⓗ࡞἞⒪ຠᯝࡣᚓࡽࢀ࡚࠸࡞࠸ࠋ
៏ᛶ⫢⅖ࡢච␿Ꮫⓗ἞⒪ἲࡢ☜❧ࡍࡿⅭࠊ࣡ࢡࢳࣥᢠཎࡸ᥋✀᪉ἲࡢ᳨ウ࡜⌧ᅾㄆྍࡉࢀ࡚࠸ࡿࢹࣥࢢ⇕࣡ࢡࢳࣥࡣࠊᮍឤᰁ⪅࡬ࡢ᥋స⏝ᶵᗎࡢゎᯒࢆ㐍ࡵࡿࠋ✀࡟ࡼࡾ࢘࢖ࣝࢫึឤᰁᚋ࡟ࡼࡾ㔜⑕໬ࡍࡿࣜࢫࢡࡀሗ࿌ࡉ ࣭᪂つࢹࣥࢢ࣡ࢡࢳࣥ࡜ྠ୍⾑Ύᆺ㸦&㸧ཬࡧ␗࡞ࡿ⾑Ύᆺ㸦ᆺ㸧࡟ᑐࡋ࡚ண㜵ຠᯝࡀ☜ㄆࡉࢀࡓⅭࠊ௒ᚋࡣࡉࡽ࡟ࠊᆺࢆྵࡵࡓ඲࡚ࡢ⾑Ύᆺ࡟ᑐࡍ
ࢀࡓⅭࠊస⏝ᶵᗎࡢ␗࡞ࡿ࣡ࢡࢳࣥࡢ㛤Ⓨࡀᮃࡲࢀ࡚࠸ࡿࠋ
ࡿண㜵ຠᯝ࡜㜵ᚚᶵᗎࢆゎᯒࡍࡿࠋ
᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࡟ᑐࡋ࡚༶᫬ⓗ࡞㜵ᚚຠᯝࢆⓎ᥹ࡍࡿ࣭」ᩘࡢ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫளᆺ࡟ᑐࡍࡿⓎ⑕ண㜵ຠᯝࡢ᳨ウ࡜㠀ᖖ࡟ᙉ࣡ࢡࢳࣥࡢ㛤Ⓨࡀᮃࡲࢀ࡚࠸ࡿࠋ
ຊ࡞ண㜵ຠᯝࢆᣢࡘ⤌᥮࠼࢖ࣥࣇ࢚ࣝࣥࢨ࣡ࢡࢳࣥࡢస⏝ᶵᗎࢆゎᯒࡍࡿࠋ  ᅜෆእࡢ◊✲≧ἣ

࣭6DQDGD7HWDOBBRC   
࣭6DQDGD7HWDOSic Rep.  
࣭<DPDQH'HWDONat Microbiol.    ࣭ ୰࿴άᛶࢆᣢࡓ࡞࠸ᵓ㐀ࢱࣥࣃࢡ㉁࡟ᑐࡍࡿᢠయࡀࢹࣥࢢ࢘࢖ࣝࢫࡢᢠయ౫
Ꮡᛶឤᰁቑᙉ㸦$'(㸧ࢆㄏⓎࡋࠊ㔜⑕໬ࢆច㉳ࡍࡿ஦ࡀᠱᛕࡉࢀ࡚࠸ࡿࡇ࡜
࠿ࡽࠊ⣽⬊ᛶච␿ㄏᑟࢆ୺య࡜ࡋࡓࢹࣥࢢ࢘࢖ࣝࢫ㠀ᵓ㐀ࢱࣥࣃࢡ㉁Ⓨ⌧ᆺ⤌᥮࠼࣡ࢡࢩࢽ࢔࣡ࢡࢳࣥ㸦'(19FU',V16*1'㸧ࡢసฟࢆ⾜࡞ࡗࡓࠋࢹࣥࢢ࢘࢖ࣝࢫឤᰁឤཷᛶ࣐࢘ࢫ࡛࠶ࡿ$*࣐࢘ࢫࢆ⏝࠸࡚ࠊ࣡ࢡࢳࣥࡢ
Ⓨ⑕㜵ᚚຠᯝࢆ᳨ウࡋࡓ⤖ᯝࠊ࣡ࢡࢳࣥ࡟౑⏝ࡋࡓ⾑Ύᆺ࡜ྠ୍⾑Ύᆺ࢘࢖ࣝࢫ & ࡟ຍ࠼࡚ࠊ␗࡞ࡿ⾑Ύᆺ࡛࠶ࡿᆺ࢘࢖ࣝࢫឤᰁ࡟ᑐࡋ࡚ࠊ㜵ᚚຠᯝࢆ᭷ࡍࡿ஦ࡀ☜ㄆࡉࢀࠊỗ⾑Ύᆺ㜵ᚚຠᯝࡢྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ

ࢆ㉸࠼࡚࠸ࡿࠋࡑࡢᡂᅉࡣࠊ%ᆺ⫢⅖࢘࢖ࣝࢫ㸦+%9㸧ࡸ&
1$6+⫢⥺⥔⑕ࣔࢹ࣐ࣝ࢘ࢫࢆ⏝࠸࡚ࠊȕFDWHQLQ&%3㑅ᢥⓗ㜼ᐖ๣35,ࡢ
ᆺ⫢⅖࢘࢖ࣝࢫ㸦+&9㸧ឤᰁࠊ࡞ࡽࡧ࡟⬡⫫ᛶ⫢⅖࡛࠶ࡿࠋᢠ⧄⥔໬ຠᯝ࡜ࡑࡢస⏝ᶵᗎࢆゎᯒࡋࡓࠋ⫢⮚ࡢ⑓⌮Ꮫⓗゎᯒ⤖ᯝ࠿ࡽࠊ+%9࡟ᑐࡋ࡚ࡣࠊ᰿ᮏⓗ࡞἞⒵ࡀྍ⬟࡞἞⒪ἲࡣࡲࡔ࡞࠸ࠋ
35,ᢞ୚⩌࡛ࡣ1$6+࡟㉳ᅉࡍࡿ⫢⥺⥔㔞ࡢ᭷ព࡞ῶᑡࡀほᐹࡉࢀࡓࠋࡲ
ࡓࠊ࣐ࢡࣟࣇ࢓࣮ࢪࡸዲ୰⌫ࡀ⏘⏕ࡍࡿ003003ࡢ⏘⏕ஹ㐍ࡀ⫢⥺⥔ᢠ࢘࢖ࣝࢫ⸆࡟ࡼࡾ+&9᤼㝖ࡀྍ⬟࡜࡞ࡗࡓࡀࠊ㧗㢠࡞἞⒪ῶᑡ࡟㛵୚ࡋ࡚࠸ࡿ஦ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ᭦࡟ࠊඹྠ◊✲ᶵ㛵࡛࠶ࡿ㒔❧㥖㈝ࡀၥ㢟࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ⫢◳ኚࡸ⫢ࡀࢇⓎ⑕ᝈ⪅࡟ᑐ㎸⑓㝔࡟࠾࠸࡚ࠊ&ᆺ⫢◳ኚᝈ⪅ࢆᑐ㇟࡜ࡋࡓ་ᖌ୺ᑟࡢ⮫ᗋ➨஧┦ヨ㦂ཬࡍࡿ᭷ຠⓗ࡞἞⒪ἲࡣᮍࡔ㛤Ⓨࡉࢀ࡚࠸࡞࠸ࠋࡼࡗ࡚ࠊࡇࢀ
ࡧ%ᆺ⫢◳ኚᝈ⪅ࢆᑐ㇟࡜ࡋࡓ⮫ᗋ➨୍┦ヨ㦂ࡀ⤊஢ࡋࡓࠋ
ࡽ⫢⑌ᝈ࡟ᑐࡍࡿᏳ඲࠿ࡘຠᯝⓗ࡛Ᏻ౯࡞᪂つ἞⒪ἲࡢ㛤Ⓨ ࣭ࡼࡾᙉຊ࡞ឤᰁ㜵ᚚຠᯝࢆ♧ࡍ +%9 ࣡ࢡࢳࣥࡢ㛤Ⓨࢆ┠ᣦࡋࠊ඲㛗 +%V ᢠཎ࡛࠶ࡿ +%V/ ࢆ⏝࠸ࡓ⤒㰯ᄇ㟝ἲ࡟ࡼࡿච␿ㄏᑟຠᯝࢆ᳨ドࡋࡓࠋ⤒㰯ᄇ㟝ཬࡧண㜵ἲࡢ☜❧ࡣࠊ㔜኱࠿ࡘ⥭ᛴⓗ࡞♫఍せㄳ࡛࠶ࡿࠋ
ἲ࡟ࡼࡾࠊ㧗࠸୰࿴ᢠయㄏᑟࡢࡳ࡞ࡽࡎ⢓⭷ච␿࡛࠶ࡿ ,J$ ㄏᑟࡶ☜ㄆࡉᖺࡸᖺ࡟Ⓨ⏕ࡋࡓࢹࣥࢢ⇕ࡢᅜෆឤᰁ஦౛ࡣࠊ
ࢀࠊࡼࡾᙉຊ࡟ච␿ㄏᑟຠᯝࢆⓎ᥹࡛ࡁࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋ
ᖏᆅᇦ࡛࠶ࡿ᪥ᮏᅜෆ࡛ࡶኟᏘ࡛࠶ࢀࡤឤᰁᣑ኱ࡋᚓࡿ஦ࢆղ ࢖ࣥࣇ࢚ࣝࣥࢨ
♧ࡋ࡚࠾ࡾࠊ⌧⾜࣡ࢡࢳࣥࡢ኱ᖜ࡞ᨵၿࡀồࡵࡽࢀ࡚࠸ࡿࠋ ࣭ 㟋㛗㢮ࣔࢹ࡛ࣝ࠶ࡿ࢝ࢽࢡ࢖ࢨࣝࢆ⏝࠸࡚ࠊ⓶ෆ᥋✀࡟ኚ᭦ࡋ࡚ࠊ࢘࢖ࣝࢫ
ࡲࡓࠊ+1ཬࡧ+1㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫ࡟ࡼࡿࣄ
ᨷᧁឤᰁ㐌๓ࡢ༢ᅇ᥋✀࡟ࡼࡿ༶᫬ᛶ㜵ᚚຠᯝࢆ᳨ウࡋࡓࠋࢥࣥࢺ࣮ࣟࣝ
⩌࡟ẚ࡭࡚ࠊU',V+ +$᥋✀⩌࡛ࡣࠊ㏿ࡸ࠿࡞ゎ⇕ࠊᣔ࠸ᾮ୰ཬࡧ⫵୰ࡢ࢘ࢺ࡬ࡢឤᰁ౛ࡣῶᑡഴྥ࡟࠶ࡿࡀࠊ㔝㫽ࡸᐙ⚺࡛ࡣୡ⏺ⓗ࡟࢖ࣝࢫ౯ ࡢ᤼㝖ຠᯝࡀㄆࡵࡽࢀࡓࠋ㟋㛗㢮ࣔࢹࣝ࡟࠾࠸࡚ࡶࠊU',6+ +$⶝ᘏࡋ࡚࠾ࡾࠊࣄࢺ࡬ࡢ෌ఏᦙࡶ༴᝹ࡉࢀ࡚࠸ࡿࡇ࡜࠿ࡽࠊ
࣡ࢡࢳࣥࡢ⓶ෆ᥋✀࡟ࡼࡿ༶᫬ᛶຠᯝࡀ☜ㄆ࡛ࡁࡓࠋ
᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࡬ࡢᑐ⟇ᙉ໬ࡶ㔜せ࡛࠶ࡿࠋճ ࢹࣥࢢ⇕  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ◊✲ᮇ㛫ᖺ᭶䡚ᖺ᭶
㸦ᖺ㛫㸧  ◊✲⪅ྡ
ᑠཎ㐨ἲ
Ᏻ஭ᩥᙪ
Ჷ᪉ ⩼
ᒣ᰿኱඾
ᒣᆅ㈼୕㑻
ᒣᮏ┤ᶞ
ᚨỌඃᏊ
┿⏣ᓫᘯ
ᮏ⏣ᬛᏊ
Ἑ㔝ࡾࡉ
㧗ᮌᮅᏊ

◊
  ✲ᮇ  㛫࣭  ◊✲  ⪅ྡ  ➼ ࢖ࣥࣇ࢚ࣝࣥࢨཬࡧ㹀ᆺ࣭㹁ᆺ⫢⅖࢘࢖ࣝࢫឤᰁ⑕ࡢண㜵࡜἞⒪㸭ឤᰁไᚚࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸Ᏻ஭ᩥᙪ㸧  ᡂᯝࡢᴫせᅜෆࡢ⫢◳ኚཬࡧ⫢ࡀࢇṚஸ⪅ᩘࡣࠊᖺ㛫୓ேཬࡧ୓ே ձ ⫢⅖  ᴫせ୺࡞◊✲ᡂᯝ 

－ 12 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

A

E

◊
       ✲       ᡂ       ᯝ㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠụ ᬛ㸧
A



(1)

E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
࢘࢖ࣝࢫឤᰁࡢ࣓࢝ࢽࢬ࣒࡟ᇶ࡙࠸ࡓ἞⒪⸆➼ࡢ㛤Ⓨ㸭࢘࢖ࣝࢫឤᰁࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ(1) ◊✲ᮇ㛫ᴫせ(1) ᡂᯝࡢᴫせ࢚ࣥࢸࣟ࢘࢖ࣝࢫ71(EV71)ࠊ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫ࡞ ࣭࣋ ࢺ ࢼ ࣒ ࡛ ศ 㞳 ࡉ ࢀ ࡓ ከ ᩘ ࡢ EV71 ⮫ ᗋ ศ 㞳 ᰴ ࡢ ẘ ຊ ࢆ 2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧࡝ᛴᛶࡢ࢘࢖ࣝࢫឤᰁ⑕ࡢ」〇ᶵᵓࠊ⑓ཎᛶⓎ⌧ᶵᵓࢆㄪSCARB2tg࣐࢘ࢫࢆ⏝࠸࡚Ỵᐃࡋࠊὶ⾜࡟ࡼࡗ࡚ẘຊࡀ␗࡞࡭἞⒪⸆➼ࢆ㛤ⓎࡍࡿࠋEV71࡜ࡑࡢཷᐜయ࡜ࡢ┦஫స⏝ࡿᰴࡀఏ᧛ࡋ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࠊㄽᩥ࡜ࡋ࡚Ⓨ⾲ࡋ (2) ◊✲⪅ྡࢆㄪ࡭ࡿࡇ࡜ࠊEV71ឤᰁື≀ࣔࢹࣝࢆస〇ࡍࡿࡇ࡜ࠊ࢖ࡓࠋᑠụ ᬛ
ࣥࣇ࢚ࣝࣥࢨ⸆ࡢ࣏࣓࣮ࣜࣛࢮάᛶࢆ㜼ᐖࡍࡿᢠ࢖ࣥࣇࣝ ࣭EV71ࡣᇵ㣴⣽⬊࡛⥅௦ࡍࡿ࡜ᙅẘ໬ኚ␗ࢆ㉳ࡇࡍࡀࠊࡇࡢ ᑠᯘ㒓௓࢚ࣥࢨ⸆ࢆ㛤Ⓨࡍࡿࡇ࡜࡞࡝ࡀ┠ᶆ࡛࠶ࡿࠋ
࣓࢝ࢽࢬ࣒ࡀ࣊ࣃࣛࣥ◲㓟࡟ᑐࡍࡿぶ࿴ᛶࡢ⋓ᚓ࡛࠶ࡿࡇ࡜
ࢆ᫂ࡽ࠿࡟ࡋࠊㄽᩥ࡜ࡋ࡚Ⓨ⾲ࡋࡓࠋ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ᅜෆࡢ⮫ᗋศ㞳ᰴࡢ୰࠿ࡽᙉẘᰴ࡜ᙅẘᰴࢆ㑅ᢤࡋࠊ࣓࢟ࣛ
࣭ Development of an Enterovirus 71 Vaccine Efficacy Testࢆసᡂࡋ࡚ẘຊࡀ5’noncoding regionࡢ㐪࠸࡟ࡼࡗ࡚ไᚚࡉࢀ
Using Human Scavenger Receptor B2 Transgenic Mice.
࡚࠸ࡿࡇ࡜ࢆぢฟࡋࡓࠋ
Imura A, et al. J Virol. 2020;94(6):e01921-19.㸦ᰝㄞ᭷㸧
࣭SCARB2tg࣐࢘ࢫEV71࣡ࢡࢳࣥࡢ᭷ຠᛶヨ㦂ࡀ෌⌧ᛶࡼࡃ⾜࣭ Heparan sulfate attachment receptor is a major selection
factor for attenuated enterovirus 71 mutants during cell࠼ࡿᐇ㦂⣔ࢆ☜❧ࡋࠊࡇࡢࢩࢫࢸ࣒࡟㛵ࡍࡿㄽᩥⓎ⾲ࡋࡓࠋ
culture adaptation. Kobayashi K, et al. PLoS Pathog.
2020;16(3):e1008428.㸦ᰝㄞ᭷㸧(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Newly emerged enterovirus-A71 C4 sublineage may be ࣭࣋ࢺࢼ࣒ᰴ࡟ࡘ࠸࡚ࡣ௒ᚋࡶ⮫ᗋศ㞳ᰴࢆྲྀᚓࡋᘬࡁ⥆ࡁ
more virulent than B5 in the 2015-2016 hand-foot-andゎᯒࢆ⾜࠺ࠋmouth disease outbreak in northern Vietnam. Chu ST, et al. ࣭ᙉẘᰴ࡜ᙅẘᰴࡢ⑓ཎᛶࡢᙉࡉࢆỴᐃࡋ࡚࠸ࡿ5’noncoding
Sci Rep. 2020;10(1):159.㸦ᰝㄞ᭷㸧
regionࡢᶵ⬟࡟ࡘ࠸࡚ヲ⣽࡟᫂ࡽ࠿࡟ࡍࡿࠋ
࣭ Cellular receptors for enterovirus A71. Kobayashi K, Koike࣭☜❧ࡋࡓ࣡ࢡࢳ᳨ࣥᐃ⣔ࢆά⏝ࡋࠊ௻ᴗ࡜ࡢඹྠ◊✲ࢆ⾜S. J Biomed Sci. 2020;27(1):23.㸦ᰝㄞ᭷㸧࠸⌧ᅾ㛤Ⓨ୰ࡢᡭ㊊ཱྀ⑓࣡ࢡࢳࣥࡢࡉࡽ࡞ࡿᨵⰋࢆ⾜࠺ࠋ(3) ᅜෆእࡢ◊✲≧ἣ࣭ࡉࡽ࡟CVA6, CVA10ࡢ」〇࡟ᚲせ࡞ᐟ୺ᅉᏊࢆྠᐃࡋࠊࡇ
EV71ࣞࢭࣉࢱ࣮㑇ఏᏊ༢㞳ࡣୡ⏺࡛ᡃࠎࡀࡣࡌࡵ࡟ᡂ
ࢀࡽࡢ࢘࢖ࣝࢫ࡟ࡶឤཷᛶࢆࡶࡘື≀ࣔࢹࣝࢆ㛤Ⓨࡍࡿࠋຌࡋࡓࠋ௒ᖺᗘࡣື≀ࣔࢹࣝࢆ⏝࠸ࡓ࢘࢖ࣝࢫࡢẘຊࡢ࣭㛤Ⓨࡋࡓ࣐࢘ࢫࣔࢹࣝࢆ࣡ࢡࢳࣥ㛤Ⓨ࡟ᙺ❧࡚ࡿࠋホ౯࡟㛵ࡍࡿ◊✲ࡀ㐍ᒎࡋࡓࠋᅜෆእ࡛ࡇࡢࡼ࠺࡞௙஦
ࡣ࡞࠸ࠋEV71࣡ࢡࢳࣥࡢ㛤Ⓨࡣ୰ᅜ࡛ᐇ⏝໬ࡉࢀࡓࡀࠊ
⏕⏘㔞࡞࡝ࡢၥ㢟ࡀ࠶ࡿࡓࡵࠊ௒ᚋࡉࡽ࡞ࡿᨵⰋࡀ࡞ࡉ
ࢀࡓ࣡ࢡࢳࣥࡀᚲせ࡜ࡉࢀ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ 

－ 13 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ  ᴫせ㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊        ✲       ᡂ       ᯝ
 

▱ᛕ┤ྐ
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㸦ᖺ㛫㸧  ◊✲⪅ྡ
Ώ㎶ఙᫀ
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࣓࢝ࢽࢬ࣒ࡀᮍࡔᮍゎ࡛᫂࠶ࡿࠋᮏ◊✲ࡣࠊ⯉ୗච␿⒪ἲࡢ
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ࡋ࡚࠸ࡃࠋ ⯉ୗච␿⒪ἲࡢ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡢ㛤Ⓨ⯉ୗච␿⒪ἲࡢዌຌᶵᗎ࡟࠾࠸࡚ࠊ7$65㑇ఏᏊ࡟ὀ┠ࡋ೺ᖖ⪅࡜ⰼ⢊⑕⪅ࢆẚ㍑ࡋ࡚ࡳࡿ࡜᭷ព࡟೺ᖖ⪅࡟࠾࠸࡚7$65  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
ࡢⓎ⌧ࡀୖ᪼ࡋ࡚࠸ࡓࠋ୍᪉ࠊࣂ࢖࣐࣮࣮࢜࢝࡜ࡋ࡚ೃ⿵ࡀୖ
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⯉ୗච␿⒪ἲࡣ᪤࡟ᅜෆእ࡛ᐇ᪋ࡉࢀ࡚࠸ࡿ࢔ࣞࣝࢠ࣮ච
ࡀࠊ⯉ୗච␿⒪ἲ࡟࠾࠸࡚7$65ࡣ⤒㐣ほᐹࡸ἞⒪ຠᯝデ᩿࡟
␿⒪ἲ࡛࠶ࡿࠋࡋ࠿ࡋ࡞ࡀࡽ἞⒪ᮇ㛫ࡀ㛗ᮇ㸦㹼ᖺ௨ୖ㸧㠀ᖖ࡟ຠᯝⓗ࡞⯉ୗච␿⒪ἲࡢࣂ࢖࣐࣮࣮࡛࢜࢝࠶ࡿࡇ࡜ࡀ᫂
࡟Ώࡿ࡟ࡶ࠿࠿ࢃࡽࡎࠊࡑࡢ἞⒵⋡ࡣ⣙⛬ᗘ࡛࠶ࡾỴࡋ ࡽ࠿࡜࡞ࡗࡓࠋࣄࢺ⣽⬊ᇵ㣴ᰴ࡬ࡢᙉไⓎ⌧⣔ࡢᵓ⠏ࡶ㐍ࡵ࡚࡚ᝈ⪅࡟࡜ࡗ࡚‶㊊࠸ࡃ⤖ᯝ࡛ࡣ࡞࠸ࠋࡑࡇ࡛ࠊస⏝࣓࢝ࢽ ࠾ࡾࠊ௒ᚋྛ✀᪤▱ࣜ࢞ࣥࢻࢆ༢⊂࠶ࡿ࠸ࡣ7⣽⬊άᛶ໬ࢩࢢࢼࢬ࣒ࡢヲ⣽ࢆゎ᫂ࡋ࡚἞⒪ࡢຠᯝࢆண ࡍࡿデ᩿ࡢ㛤Ⓨࡣ㔜 ࣝࡢᏑᅾୗ࡛ࠊ&'7⣽⬊࡟࠾ࡅࡿ7$65ࡢච␿ᛂ⟅࡜ࡑࡢࢩせ࡛࠶ࡿࠋ
ࢢࢼࣝఏ㐩ᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

୺࡞◊✲ᡂᯝ 

－ 14 －

(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ HIF2ࢆ௓ࡍࡿ⾑⟶᪂⏕ࡢㄪ⠇ᶵᗎ࡟࠾࠸࡚ࠊInt6-siRNAࡢ⤖ㄽᩥᥖ㍕ྜ≀㉁࡜ࡋ࡚ࡢODAGal4ࡢຠᯝࡣࠊண᝿௨ୖ࡟ᙉࡃᵝࠎ࡞ࢱ
࣭ Drug Metab Pharmacokinet, 2019.
࢖ࣉࡢsiRNA࡟౑⏝࡛ࡁࡿࡇ࡜ࡀド࡛᫂ࡁࠊᏛ఍ࠊㄽᩥⓎ⾲࣭ Drug Metab Dispos, 2019.
ࢆ⾜࠺࡜࡜ࡶ࡟≉チࢆ⏦ㄳࡋࡓࠋ௒ᚋࡣࠊᛂ⏝࡟ྥࡅࡓඹྠ
Ꮫ఍◊✲ࢆ㐍ࡵࡿࠋ
࣭ ➨140ᅇ᪥ᮏ⸆Ꮫ఍ࠊ2020.3.25 ி㒔ᕷ࣭ ⣽⬊⼥ྜ࡟ࡼࡿ⣽⬊ࡢఇ╀໬ࠊ࠶ࡿ࠸ࡣᝏᛶ໬࡟㛵ࡋ࡚ࡣࠊ࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍ 2019.12.05 ⚟ᒸື≀ᐇ㦂ࡢ⤖ᯝࡶྵࡵᏛ఍Ⓨ⾲ࢆ⾜࠺࡜࡜ࡶ࡟ㄽᩥ໬ࡍࡿࠋ࣭ ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘ 2019.12.20 ᮾி ➼≉チฟ㢪 ࠕ࢝ࢳ࢜ࣥᛶேᕤ࢜ࣜࢦ⢾࡟ࡼࡿ஧㔜㙐 RNA ࡢ ࣭ 5-FUࡢ⾑୰ ᐃ࢟ࢵࢺ࡟㛵ࡋ࡚ࡣࠊ⮫ᗋࢧࣥࣉ࡛ࣝࡢ᳨ᐃࢆ
⾜࠸Ⰻዲ࡞⤖ᯝࢆᚓࡓࠊ௒ᚋࡣࠊ⮫ᗋヨ㦂ࢆ㏻ࡋ࡚᪩ᮇࡢ〇Ᏻᐃ໬ࠖ㸦2019 ᖺ 8 ᭶ 30 ᪥ ᅜእฟ㢪㸧ရ໬࡟ྥࡅࡓྲྀࡾ⤌ࡳࢆ㐍ࡵࡿࠋ(3) ᅜෆእࡢ◊✲≧ἣ࣭ ࠕᮾிࣂ࢖࣐࣮࣮࢜࢝࢖ࣀ࣮࣋ࢩࣙࣥᢏ⾡◊✲⤌ྜྛศ㔝࡜ࡶࠊᅜෆࠊᅜእࡢඛᑟⓗ࡞ᇶ♏◊✲ࠊ࠾ࡼࡧᐇ⏝㸦TOBIRA㸧ࠖࡣࠊ௒ᚋ࡜ࡶࡉࡽ࡟Ⓨᒎࡉࡏࠊከᦶᆅ༊࡟࠶
໬◊✲ࢆ᥎㐍ࡋ࡚࠸ࡿࠋ
ࡿ㒔❧⑓㝔⩌࡜ࡢᶫΏࡋ◊✲ࡢⓎᒎ࡟ࡘ࡞ࡆࡿࠋ≉࡟᮶ᖺᗘ࠙ ᩍ ⫱ ά ື ࠚ Ⱚ ᓮ ኴ 㸸 㡑 ᅜ ᘏ ୡ ኱ Ꮫ ࣭ ᐈ ဨ ᩍ ᤵ 㸦 2014 ᖺࡣࠊከᦶ⥲ྜࠊከᦶᑠඣࠊ㥖㎸⑓㝔➼ࢆ୰ᚰ࡟5-FU࢟ࢵࢺࢆ⏝࠸ࡓ⮫ᗋヨ㦂ࢆ⾜࠼ࡿయไࢆࡉࡽ࡟㐍ࡵ࡚࠸ࡃணᐃ࡛࠶ࡿ
㹼㸧ࠊග⏘ᴗ๰ᡂ኱Ꮫ㝔኱Ꮫ࣭ᐈဨᩍᤵ㸦2015ᖺ㹼㸧࣭ ࢖ࣥࣇ࢚ࣝࣥࢨࡢデ᩿࢟ࢵࢺࡢࡇࢀࡲ࡛ࡢࣀ࢘ࣁ࢘ࡣࠊ᮶ᖺ
ᗘࢥࣟࢼ࢟ࢵࢺ࡟⧅ࡆࡿ‽ഛࢆ㐍ࡵ࡚࠸ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(1) ᡂᯝࡢᴫせ࣭ ప㓟⣲཯ᛂᛶᅉᏊHIF2ࡢㄪ⠇ᅉᏊInt6ࡢsiRNAࢆᐇ⏝໬ࡍࡿࡓࡵ ࠊ siRNA ࡢ Ᏻ ᐃ ໬ ἲ ࡜ ࡋ ࡚ ⌮ ⛉ ኱ Ꮫ ࡜ ඹ ྠ ◊ ✲ ࡟ ࡚
ODAGal4࡜ࡢే⏝࡛㛗ᮇ㛫ࡢᏳᐃ໬ἲ☜❧ࡋ≉チ໬ࡋࠊࡲࡓ
Ꮫ఍Ⓨ⾲࠾ࡼࡧㄽᩥ࡜ࡋ࡚ᢞ✏ࡋࡓࠋ࣭ ⣽⬊⼥ྜ࡟ࡼࡿ⒴໬ࡢ◊✲࡛ࡣࠊ᪂ࡓ࡞ᶆⓗᅉᏊࡀぢࡘ࠿
ࡾࠊ⒴໬࡟࠾ࡅࡿ⣽⬊⼥ྜࡸ⸆๣⪏ᛶ࡞࡝ࡢᶵᗎࡀ᫂ࡽ࠿࡟
࡞ࡾࡘࡘ࠶ࡿࠋ࣭ 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨࡢ᪂ࡋ࠸౵ධ⤒㊰࡟㛵ࢃࡿHAࡢ㓄ิࡀస〇ࡋࡓᢠయ࡟ࡼࡾྠᐃ࡛ࡁࠊᏛ఍Ⓨ⾲ࢆ⾜࠺࡜࡜ࡶ࡟
ㄽᩥᢞ✏ࡋࡓࠋ࣭ ᮾ㒊ᆅᇦ⑓㝔࠿ࡽࡢせᮃ࡛ࠊᢠࡀࢇ๣5-FUࡢ⾑୰ ᐃ⡆᫆࢟ࢵࢺ࡟ࡼࡿヨ㦂ⓗ࡞ ᐃࢆ⾜ࡗࡓࠋEᴫせᮏ◊✲ࡣࠊࡀࢇࠊឤᰁ⑕࡞࡝ࡢ⑌ᝈ࡟ࡘ࠸࡚ࠊ㒔❧࣭බ♫⑓㝔ࢆྵࡴᅜෆእࡢ⑓㝔ࠊ኱Ꮫࠊ◊✲ᡤࠊ௻ᴗ࡜ࡢඹྠ◊✲ࢆ㏻ࡋ࡚ࠊ᪂つデ᩿ἲ࣭἞⒪ἲ㛤Ⓨࢆᇶᮏ࡟࠾࠸ࡓᇶ♏࣭⮫ᗋ◊✲࠾ࡼࡧࠊࡇࢀࡽࡢᡂᯝࢆ㒔Ẹࡢ་⒪࣭⚟♴࡟㑏ඖࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ◊✲ࢸ࣮࣐࡜ࡋ࡚ࠊ
࣭ ⒴໬ࡢᶵᗎゎ᫂㸸ప㓟⣲ࢫࢺࣞࢫࡸ⣽⬊⼥ྜࢆ௓ࡋࡓ᪂
つไᚚᶵᵓࡢゎ᫂࡜๰⸆࣭ 㧗⑓ཎᛶ࢖ࣥࣇ࢚ࣝࣥࢨࡢ⑓ែゎ᫂࡜๰⸆࣭ デ᩿ἲ㛤Ⓨ㸸㧗㏿㑇ఏᏊቑᖜ⿦⨨ࡸ࢖࣒ࣀࢡ࣐ࣟࢺ➼ࡢ㛤Ⓨ
࣭ TOBIRA ࢆ௓ࡋࡓ⏘Ꮫ㐃ᦠࡢ᥎㐍࡟ࡼࡿᶫΏࡋ◊✲ࠊ㥖㎸⑓㝔➼ࡢࣂ࢖࢜ࣂࣥࢡ

(1)

A

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  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ◊✲⪅ྡ㸦་Ꮫ◊㸧Ⱚᓮ ኴࠊྑ⏣ᩄ㑻኱ಖᮌၨ௓ࠊᲚཎ┤ᶞ⏣ᓥ㝧୍ࠊᕝᓥ⫱ኵධỤ ᩔࠊ㰺⸨⣪ᕼෆ⸨ᬡᏹࠊḈ஭ 㝧㔝ᮧዉ⨾Ꮚࠊᑠᕝ⨾ዉ㐲⸨඾Ꮚࠊ᪩ᕝⱥẎ᳃ᐿⰾோࠊᏱᲚ㯞⣪Ꮚ⣽ᕝᖾ⏕ࠊΎỈ㐩ဢ୰㔝᪩▱ᰤࠊᶫᮏᣅஓ㈆௵኱ᆅࠊୖ⏣ᙬ஀኱ᒇ཭⣖ࠊᮾ ▖ᖹ㛫༓ὠᏊࠊ㞵㈅㝧௓㸦㥖㎸⑓㝔㸧㯮஭ඞ᫂ᇼཱྀ┿୍㑻 
ᮌᮧබ๎
኱⃝㝧௓
ẚᓥᜏ࿴

㸦ከᦶᑠඣ་⒪ࢭࣥࢱ࣮㸧㛗㇂ᕝ⾜ὒ
ᮏ⏣㞞ᩗࠊ௚
㸦ᮾ㒊ᆅᇦ⑓㝔㸧ᰙᒣᑦ⣖ࠊⴠྜ ໶(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾࡀࢇ࣭ឤᰁ⑕ࡢศᏊᶆⓗ᥈⣴࡟ࡼࡿデ᩿࣭἞⒪ἲࡢ㛤Ⓨ㸭ศᏊ་⒪ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸Ⱚᓮ ኴ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 15 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ࠶ࡾ〇⸆௻ᴗ➼ࡶᙉ࠸㛵ᚰࢆᐤࡏ࡚࠸ࡿࠋ

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ᡂᯝࡢᴫせձ ኱⬻⓶㉁ᇶᗏ᰾ኚᛶ⑕ &%' ࢱ࢘ࡢࢡࣛ࢖࢜㟁㢧࡟ࡼࡿᵓ㐀ゎ᫂࣭ⱥᅜ05& /0%࡜ࡢඹྠ◊✲࡛ࠊ&%'ᝈ⪅⬻࡟⵳✚ࡍࡿ␗ᖖᆺࢱ࢘
⥺⥔ࢆࢡࣛ࢖࢜㟁Ꮚ㢧ᚤ㙾࡛ゎᯒࡋࠊୡ⏺࡛ึࡵ࡚cac࡛ࣞ࣋ࣝࡑࡢᵓ㐀ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡑࢀࡽࡣ⑕౛㛫࡛ྠ୍࡛࠶ࡗࡓࡀࠊ࢔
ࣝࢶࣁ࢖࣐࣮⑓ࠊࣆࢵࢡ⑓ࠊ៏ᛶእയᛶ⬻⑕ࡢ␗ᖖᆺࢱ࢘ࡢᵓ㐀࡜ࡣ␗࡞ࡗ࡚࠾ࡾࠊࡑࡢ୰ᚰᵓ㐀ࡣࠊ⧞ࡾ㏉ࡋ㓄ิ 5 ࡢ᭱ᚋࡢṧ
ᇶࠊ5ࠊ5ࠊ5ࡢ඲యࠊ࠾ࡼࡧ5ࡢᚋࡢಶࡢ࢔࣑ࣀ㓟࡟ࡲࡓࡀ
ࡿࢱ࢘ࡢ.(ࢆྵࡴ᪂つࡢ㸲ᒙᵓ㐀࡛࠶ࡗࡓࠋ◊        ✲       ᡂ       ᯝ   ◊✲ᮇ㛫ᖺ᭶䡚ᖺ᭶
㸦ᖺ㛫㸧  ◊✲⪅ྡ
㛗㇂ᕝᡂே
㔝୰ 㝯
⣽ᕝ㞞ே
㕥ᮌඖ἞㑻
㕥᥃㞞⨾
຾ཪ ❳
ட㇂ᐩ⏤ᶞ
ᮌᮧጁᏊ
ᖹ஭ஂ⨾
Ἑୖ ⥴
Ώ㎶ுᖹୗἑ᫂ᕼ஭ᮧ ᡂ
ᶡ㇂ឡ⌮
⏣୰Ⰻἲ
ஂỌ┾ᕷ
⛅ᒣ἞ᙪ

◊
  ✲ᮇ  㛫࣭  ◊✲  ⪅ྡ  ➼ ㄆ▱⑕ࡢⓎ⑕࡜㐍⾜ᶵᗎࡢゎ᫂㸭ㄆ▱⑕ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㛗㇂ᕝᡂே㸧

ղ 7'3 ࣉࣟࢸ࢖ࣀࣃࢳ࣮ࡢ⮫ᗋ⑓⌮࡜ᇶ♏ ࣭๓㢌ഃ㢌ⴥኚᛶ⑕ )7/' ࡸ➽ⴎ⦰ᛶഃ⣴◳໬⑕ $/6 ࡞࡝ࡣኚᛶࡍ
ࡿ⚄⤒⣽⬊ࠊࢢࣜ࢔⣽⬊ෆ࡟␗ᖖᆺ7'3ࡀ⵳✚ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊࡑࡢ⑓⌮࡜⑓ᆺࠊ⑓ኚࡢᗈࡀࡾ࡜⮫ᗋ⑕≧ࡀᐦ᥋࡟㛵ಀࡋ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࡚࠸ࡿࠋࡑࡇ࡛ࠊࡇࢀࡲ࡛࡟ሗ࿌ࡉࢀ࡚࠸ࡿ7'3⵳✚࡜క࠺⑓Ẽ࣭ =KDQJ : 7DUXWDQL $ 1HZHOO . 0XU]LQ $ 0DWVXEDUD 7࡟ࡘ࠸࡚⮫ᗋࠊ⑓⌮Ꮫⓗ࡟ࢡࣛࢫศ㞳ࢆ⾜࠸ࠊࡇࢀࡲ࡛ࡢ7'3ࡢ
)DOFRQ%9LGDO5*DUULQJHU+6KL<,NHXFKL70XUD\DPDᇶ♏ⓗࠊᐇ㦂ⓗ◊✲ࢆ⤫ྜࡋࠊ7'3࠿ࡽࡳࡓ᪂ࡋ࠸⮫ᗋ⑓ᆺࡢᥦ
6 *KHWWL % +DVHJDZD 0 *RHGHUW 0 6FKHUHV 6+: 1RYHOၐ࡜⑓ែ㐍⾜ࡢ࣓࢝ࢽࢬ࣒ࡢྍ⬟ᛶ࡟ࡘ࠸࡚グ㍕ࡋࡓࠋ
WDX ILODPHQW IROG LQ FRUWLFREDVDO GHJHQHUDWLRQ 1DWXUH ճ Șࢩࢾࢡࣞ࢖ࣥఏ᧛࡟ᑐࡍࡿࣞ࣎ࢻࣃࡢຠᯝ )HEGRLV
࣭ .DZDNDPL , $UDL 7 +DVHJDZD 0 7KH EDVLV RI ࣭ࣞ࣎ࢻࣃࡣࣃ࣮࢟ࣥࢯࣥ⑓἞⒪⸆ࡢࢦ࣮ࣝࢻࢫࢱࣥࢲ࣮ࢻ࡛࠶ࡾࠊ
ࡑࡢ⿵඘⒪ἲࡀ3'ࡢ⑕≧ᨵၿࡸࠊ42/ࡢ㛗ᮇ⥔ᣢࠊᖹᆒᑑ࿨ࡢᘏ㛗
FOLQLFRSDWKRORJLFDO KHWHURJHQHLW\ LQ 7'3 SURWHLQRSDWK\ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊ࣐࢘ࢫ࡟⥺⥔໬Șࢩࢾࢡࣞ࢖ࣥࢆ᥋✀$FWD1HXURSDWKRO1RY  
ࡋ࡚⑓ኚࢆᙧᡂࡉࡏࡿࣔࢹࣝࢆ⏝࠸࡚ࠊȘࢩࢾࢡࣞ࢖ࣥ⑓ኚࡢᙧᡂ
࣭ 6KLPR]DZD $ )XMLWD < .RQGR + 7DNLPRWR < 7HUDGD 0ࡸఏ᧛ࢆᢚไࡍࡿຠᯝ࡟ࡘ࠸᳨࡚ウࡋࡓࠋࡑࡢ⤖ᯝࠊᢞ୚⩌࡟࠾࠸
6XQDJL 0 +LVDQDJD 6, +DVHJDZD 0 (IIHFW RI /࡚㯮㉁࡟࠾ࡅࡿȘࢩࢾࢡࣞ࢖ࣥࡢจ㞟ࠊ࣐࢘ࢫࡢ⬻࡟࠾ࡅࡿ⑓ⓗȘ'23$EHQVHUD]LGH RQ SURSDJDWLRQ RI SDWKRORJLFDO Įࢩࢾࢡࣞ࢖ࣥࡢఏ᧛ࢆᢚไࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
V\QXFOHLQ)URQW
1HXURVFL

GRLIQLQV࡯࠿  ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼  ᅜෆእࡢ◊✲≧ἣ࣭ ௒ᚋࡶᘬࡁ⥆ࡁࠊᵝࠎ࡞ㄆ▱⑕ࠊ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែᙧᡂ࡜㐍⾜࡟ᮏࣉࣟࢪ࢙ࢡࢺࡢ୺せࢸ࣮࣐࡛࠶ࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢఏ᧛࡟
㛵ࢃࡿࢱ࢘ࠊĮࢩࢾࢡࣞ࢖ࣥࠊ7'3ࡢ⵳✚ࠊ␗ᖖ⑓⌮࡟ࡘ࠸࡚ヲ㛵ࡍࡿ◊✲ࡣࠊୡ⏺ⓗ࡟ࡶ኱ࡁ࡞ὀ┠ࢆ㞟ࡵ࡚࠾ࡾ⚄⤒ኚᛶ⑌⣽࡟᳨ウࡍࡿ࡜ඹ࡟ࠊඹྠ◊✲࡟ࡼࡾࡑࢀࡽࡢ␗ᖖᵓ㐀ࡢゎ᫂ࢆ⾜ᝈࠊㄆ▱⑕◊✲࡟࠾ࡅࡿ኱ࡁ࡞₻ὶ࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ⣽⬊࠺ࠋࡲࡓᐇ㝿ࡢ⑓ែ࡟㏆࠸ヨ㦂⟶ࠊ⣽⬊ࠊື≀ࣔࢹࣝࡢᵓ⠏ࠊㄆ▱ෆࡢ␗ᖖࢱࣥࣃࢡ㉁ࡢఏ᧛ไᚚࡣ἞⒪ࢆ⪃࠼ࡿୖ࡛ࡶ㔜せ࡛⑕⑌ᝈࡢ἞⒪ἲࠊ἞⒪⸆ࡢ㛤Ⓨ࡟㈉⊩ࡍࡿ◊✲ࢆ㐍ࡵ࡚࠸ࡁࡓ࠸ࠋ

㉸㧗㱋໬♫఍ࡢ㐍ᒎ࡟క࠸ࠊㄆ▱⑕ࡣ㤳㒔ᮾி࡟࠾࠸࡚ࡶ
኱ࡁ࡞♫఍ၥ㢟࡜࡞ࡗ࡚࠾ࡾࠊࡑࡢཎᅉゎ᫂࡜἞⒪ἲࡢ㛤Ⓨࡀᛴົ࡛࠶ࡿࠋㄆ▱⑕ࡣࡑࡢ⑕≧ࡸ⑓ែ࡟ࡼࡾศ㢮ࡉࢀ࡚࠸ࡿࡀࠊ⑕≧ࢆᘬࡁ㉳ࡇࡍཎᅉࢱࣥࣃࢡ㉁ࡢ✀㢮㸦ࢱ࢘ࠊĮࢩࢾࢡࣞ࢖ࣥࠊ7'3࡞࡝㸧࡟ࡼࡗ࡚ศ㢮ࡉࢀࡿࠋཎᅉࢱࣥࣃ
ࢡ㉁ࡢ␗ᖖ⑓ኚࡢᗈࡀࡾࡀ⑓ែ㐍⾜࡜῝ࡃ㛵ࢃࡗ࡚࠾ࡾࠊࡇ
ࢀࡽࡢ␗ᖖ⑓ኚࡢᙧᡂᶵᗎࡸᗈࡀࡾࢆᢚ࠼ࡿࡼ࠺࡞἞⒪ἲࢆ
㛤Ⓨࡍࡿࡓࡵࡢ◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࡲࡓࠊ㒔❧⑓㝔➼࡜ࡢ㐃ᦠ࡟ࡼࡾᝈ⪅⬻ヨᩱࡢヲࡋ࠸⏕໬Ꮫゎᯒࢆ⾜࠸ࠊࡑࡢ⤖ᯝࢆ⮫ᗋࡢ⌧ሙ࡟㑏ඖࡍࡿ࡜࡜ࡶ࡟ࠊ⸆ຠホ౯ࡢࡓࡵࡢᐇ㦂ࣔࢹࣝࡢస〇࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ  ᴫせ୺࡞◊✲ᡂᯝ 

－ 16 －

Matsuno M et al, iScience 15, 55-65 (2019).
Ueno K et al, J Neurosci. 40, 3533-3548 (2020)
Suzuki et al, Eur J Immnol 50, 205-219 (2020)

(3)ᅜෆእࡢ◊✲≧ἣࢥࢿࢡࢺ࣮࣒ゎᯒ➼࠿ࡽ⚄⤒⣽⬊ࡢ⤖ྜᵝᘧࡀ୍⣽⬊࡛ࣞ࣋ࣝヲ⣽࡟㐍ࡳࠊྛ⾜ື㐣⛬࡛ࡢ⚄⤒άື࡟ᑐࡍࡿゎ๗Ꮫⓗᑐᛂ௜ࡅin vivo࢖࣓࣮ࢪࣥࢢ࡞࡝࡟ࡼࡾ኱ࡁࡃ㐍ᒎࡋ࡚࠸ࡿࠋ୍᪉࡛༢࡞ࡿ⚄⤒άື࡛ࡣㄝ᫂ฟ᮶࡞࠸஦㇟ࡶぢฟࡉࢀ࡚࠾ࡾࠊࡇࡢゎ᫂ࡀ⬻ࡢാࡁࢆ⌮ゎࡍࡿୖ࡛୙ྍḞ࡛࠶ࡿࡇ࡜ࡀㄆ㆑ࡉࢀ࡚ࡁ࡚࠸ࡿࠋ

(2)
࣭
࣭
࣭

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ 㛗ᮇグ᠈Ꮫ⩦ᚋࡢຍ㱋య࡟࠾ࡅࡿࢻ࣮ࣃ࣑ࣥసືᛶ⚄⤒ࡢ⚄⤒άືࡀ࡝ࡢࡼ࠺࡞௙⤌ࡳ࡛グ᠈ỗ໬ࢆᘬࡁ㉳ࡇࡍࡢ࠿࡟ࡘ
࠸࡚ࠊࢻ࣮ࣃ࣑ࣥసືᛶ⚄⤒⣽⬊ࡸグ᠈⑞㊧⣽⬊ࡢ࢖࣓࣮ࢪ
ࣥࢢゎᯒ࡞࡝࠿ࡽ᫂ࡽ࠿࡟ࡍࡿࠋ࣭ ࢢࣜ࢔⣽⬊࡟ࡼࡿឤぬ᝟ሗࡢఏ㐩ᶵᗎ࡟ࡘ࠸࡚ࠊࢩࢼࣉࢫ࣭
ཷᐜయ࡛ࣞ࣋ࣝ᫂ࡽ࠿࡟ࡍࡿࠋ࣭ ᪂つࢻ࣮ࣃ࣑ࣥࢭࣥࢧ࣮ࢆ⏝࠸ࡓin vivo࢖࣓࣮ࢪࣥࢢ࡜⾜ື㑇ఏᏛⓗᡭἲࢆ⤌ࡳྜࢃࡏࠊ㐃ྜᏛ⩦㐣⛬࡛ࡢࢻ࣮ࣃ࣑ࣥᨺ
ฟࢱ࢖࣑ࣥࢢ࡜⾜ືᏛⓗ▱ぢ࡜ࡢ┦㛵ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ࣭ ᝟ືఏᰁࢆᢸ࠺⚄⤒ᅇ㊰ࢆྠᐃࡍࡿ࡜ඹ࡟ࡑࡢືసཎ⌮ࢆゎ๗㑇ఏᏛⓗᡭἲࢆྲྀࡾධࢀ࡚᫂ࡽ࠿࡟ࡍࡿࠋᡂᯝࡢᴫせ࣭ ຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖࡢᐇయࡀ㛗ᮇグ᠈ᙧᡂ࡛↓ࡃᙧᡂᚋࡢಖ
ᣢ㐣⛬࡛ࡢグ᠈᝟ሗಟ㣭࡟ࡼࡿグ᠈ỗ໬࡛࠶ࡿࡇ࡜ࠊࡇࡢグ᠈᝟ሗಟ㣭࡟ࠊᏛ⩦ᚋࡢࢻ࣮ࣃ࣑ࣥసືᛶ⚄⤒⣽⬊ࡢ⚄⤒άືࡀ㛵୚ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚᎘ᝏᛶໝ࠸᮲௳௜ࡅ࡟࠾࠸࡚ࠊ⚄⤒⣽⬊࡛࡞ࡃグ᠈୰ᯡ࢟ࣀࢥయࢆྲྀࡾᅖࡴࢢࣜ࢔⣽⬊ࡀ࢟ࣀࢥయ࡟᎘
ᝏ᝟ሗࢆఏ㐩ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ༢㞳ᇵ㣴⬻ࡢ࢖࣓࣮ࢪࣥࢢゎᯒ࠿ࡽ㐃ྜ่⃭ࢆཷࡅࡓ࢟ࣀࢥ
య⚄⤒⣽⬊࡟ࡼࡾㄏᑟࡉࢀࡿ࢜ࣥࢹ࣐ࣥࢻ࣭ࢻ࣮ࣃ࣑ࣥᨺฟ
ࡢศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡓ㸦ୖ㔝ࡽࠊJ Neurosci 2020㸧ࠋࡉࡽ࡟᪂つࢻ࣮ࣃ࣑ࣥࢭࣥࢧ࣮ࢆ⏝࠸࡚ࠊໝ࠸᎘ᝏᏛ⩦㐣⛬࡛ࡢࢻ࣮ࣃ࣑ࣥᨺฟືែࢆin vivo࢖࣓࣮ࢪࣥࢢ࡛ㄪ࡭ࠊ㐃ྜᏛ⩦࡟౫ᏑࡋࡓᏛ⩦┤ᚋ࠿ࡽࡢࢻ࣮ࣃ࣑ࣥᨺฟࢆほᐹࡋࡓࠋ࣭ ⇕㏨㑊⾜ືࢆᣦᶆ࡜ࡋ࡚ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡛᝟ືఏᰁࢆぢฟࡋࠊࡇࢀ࡟㛵୚ࡍࡿࢭࣟࢺࢽࣥసືᛶ⚄⤒⣽⬊ࢆྠᐃࡋࡓࠋ
(1)

ᴫせᏛ⩦࣭グ᠈ࡢ࣓࢝ࢽࢬ࣒ࢆ⣽⬊࣭ᅇ㊰ࣞ࣋ࣝ࠿ࡽ㑇ఏᏊ࣭ศᏊࣞ࣋ࣝ࡟࠿ࡅ࡚ゎᯒࡍࡿࠋ᫂ࡽ࠿࡟࡞ࡗࡓᏛ⩦グ᠈ࡢ࣓࢝ࢽࢬ࣒࡟↷ࡽࡋࠊຍ㱋ࡸ⑌ᝈ࡞࡝࡟ࡼࡾ㉳ࡇࡿㄆ▱㞀ᐖࡢཎᅉࢆ᫂ࡽ࠿࡟ࡋࠊண㜵࣭ᨵ
ၿ࣭἞⒪ࡢ᪉ἲㄽࡢ☜❧࡟㈉⊩ࡍࡿࠋ(1)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ(2) ◊✲⪅ྡ㰺⸨ ᐇ
ᐑୗ▱அ
ୖ㔝⪔ᖹ
ᯇ㔝ඖ⨾
㛗㔝ៅኴ㑻㕥ᮌຊ᠇(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

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  㛫࣭  ◊✲  ⪅ྡ  ➼Ꮫ⩦グ᠈ᶵᵓࡢཎ⌮࡜㞀ᐖࡢゎ᫂㸭Ꮫ⩦グ᠈ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㰺⸨ ᐇ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 17 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼

࣭

࣭

(3)

࣭

ᅜෆእࡢ◊✲≧ἣ⬨㧊࡬ࡢேᕤ⚄⤒᥋⥆ࡣすᮧࡀࣃ࢖࢜ࢽ࢔࡛࠶ࡾࠊ⚄⤒ᶵ(2)ᗎゎ᫂ࢆ┠ᣦࡋࡓ◊✲࡛ࡶࠊ⮫ᗋ◊✲࡟࠾࠸࡚ࡶୡ⏺ࢆඛᑟ࣭ࡋ࡚࠸ࡿࠋࡲࡓࠊື≀ࣔࢹࣝࢆ⏝࠸ࡓពḧ࡟㛵ࢃࡿഃᆘ᰾ࡀ
⬨㧊ᦆയᚋ࡟ᶵ⬟ᅇ᚟࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ◊✲ࡶࠊす࣭ᮧࡀぢฟࡋࡓࡶࡢ࡛࠶ࡾࠊࡑࢀࢆࣄࢺ࡬ᒎ㛤ࡋ࡚࠸ࡿࠋࡇࡢ
ᡂᯝࡣ⢭⚄⛉㡿ᇦ࡜ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ㡿ᇦࢆ⧅ࡆࡿࡶࡢ࡜
࡞ࡿ࡜⪃࠼ࡽࢀࠊ௒ᚋ኱ࡁ࡞ὀ┠ࡀ㞟ࡲࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࠋㄽᩥᥖ㍕ㄅ࣭ Nature Communications
࣭ Science Advances࣭ Cerebral Cortex
࣭ Frontiers in Neuroscience࣭ Journal of Neural Engineering࣭ Neuroscience Research࣭ Sports Science Research⥲ㄝ࣭ Clinical Neuroscience ➼

(2)

(1)

ᴫせ
(1)
⸆≀ࠊ⣽⬊⛣᳜ࠊBrain computer Interface(BCI)ᢏ⾡࡟ࡼࡿே ࣭ᕤ⚄⤒᥋⥆ࠊ㑇ఏᏊᑟධࠊ᝟ືࡢ᧯సࡢ⤌ࡳྜࢃࡏ࡟ࡼࡾࠊ
ᶵ⬟ᅇ᚟࣭෌ᘓຠᯝࢆ᭱኱㝈࡟ᘬࡁฟࡍࣁ࢖ࣈࣜࢵࢻ἞⒪ἲࢆື≀ࣔࢹࣝ࡟࡚㛤Ⓨࡋࠊࡇࢀࢆࣄࢺࡢ⬻࣭⬨㧊ᦆയᝈ⪅࡛ࡑࡢ᭷ຠᛶࢆ⮫ᗋ◊✲࡟࡚ド᫂ࡍࡿࠋࡇࢀ࡟ࡼࡾ⬻⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟࣭෌ᘓࢆ᭱኱໬ࡍࡿ㠉᪂ⓗ࡞἞⒪ἲࢆ☜❧ࡋࠊ ࣭ࡑࡢᶵ⬟ᅇ᚟ᶵᗎࡢゎ᫂ࢆࡍࡿࠋ

୺࡞◊✲ᡂᯝ E

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⬨㧊ᦆയᝈ⪅࡜⬻᱾ሰᝈ⪅࡟ᑐࡋ࡚ேᕤ⚄⤒᥋⥆࡟ࡼࡿ㝶ពṌ⾜ᶵ⬟ࡢ෌ᘓࡢ⮫ᗋ◊✲ࢆᐇ㊶ࡍࡿࠋ⬨㧊ᦆയࣔࢹࣝࢧࣝ࡟ᑐࡋ࡚ࠊ⬻࡜⬨㧊࡜ࢆேᕤ⚄⤒᥋⥆ࢆ௓ࡋ࡚⧅ࡄேᕤ㐠ື⚄⤒⤒㊰࡜ࠊ㐠ື㔝࡜యᛶឤぬ㔝ࢆ⧅ࡄேᕤయᛶឤぬ⚄⤒⤒㊰ࢆᙧᡂࡍࡿࠋ
⢭⚄≧ែࡢእⓎ࣭ෆⓎⓗ᧯స࡟ࡼࡿ⬻άື࡜㐠ືᡂᯝࡢ᧯
సἲࢆ㛤Ⓨࡍࡿࠋ⢭⚄≧ែࢆᕥྑࡍࡿࣔࣀ࢔࣑ࣥ⣔⚄⤒ఏ㐩≀㉁ࡢィ ࡜ࡑࡢ᧯స࡟ࡼࡾࠊ㐠ືไᚚ࡟ᑐࡍࡿࣔࣀ࢔
࣑ࣥࡢ㛵୚ࢆド᫂ࡍࡿࠋᡂᯝࡢᴫせ⬻᱾ሰࢧࣝࡢ኱⬻⓶㉁࡜ᡭࡢ㯞⑷➽ࢆேᕤ⚄⤒᥋⥆࡟࡚⧅ࡄࡇ࡜࡟ࡼࡗ࡚㯞⑷ᡭࡢ㝶ព㐠ືᶵ⬟ࢆ෌ᘓࡍࡿࡇ࡜࡟ᡂ
ຌࡋࡓࠋ⬻᱾ሰࢧࣝࡣ኱⬻⓶㉁ࡢάືࢆ㝶ពⓗ࡟ኚㄪࡍࡿ
ࡇ࡜ࡀ࡛ࡁࠊ኱⬻⓶㉁ࡢᰂ㌾࡞㐺ᛂ࡟ࡼࡾ㐠ືᶵ⬟ࡢ෌ᘓࡀ࡛ࡁࡿࡇ࡜ࢆド᫂ࡋࡓ㸦Nature Comm㸧ࠋ୍ḟయᛶឤぬ㔝࡜㐠ື㔝ࡢάືࠊឤぬཷᐜჾ࠿ࡽࡢಙྕࠊ
➽⫗ࡢάືࡢ㐠ືឤぬไᚚࡢከ㡿ᇦࡢ⚄⤒άືࢆྠ᫬࡟ィࡋࠊࡑࡢ⭾኱࡞ᐇ㦂ࢹ࣮ࢱࢆ⬻᝟ሗࢹࢥ࣮ࢹ࢕ࣥࢢᢏ⾡࡛ゎᯒࡋࡓ࡜ࡇࢁࠊ୍ḟయᛶឤぬ㔝ࡀᡭࢆື࠿ࡍࡼࡾࡶ๓
ࡢ᫬Ⅼ࡟㐠ື㔝࠿ࡽ͆ࡇࢀ࠿ࡽࡣࡌࡲࡿືࡁ͇࡟㛵ࡍࡿ஦๓᝟ሗࢆཷࡅྲྀࡗ࡚࠸ࡿ࡜࠸࠺ドᣐࢆぢࡘࡅࡿࡇ࡜ࡀ࡛ࡁ
ࡓ (Science Advances)ࠋ
ࣄࢺࡢయᛶឤぬ㔝ࢆ㟁Ẽ่⃭ࡍࡿࡇ࡜࡟ࡼࡾࠊ᪥ᖖ⏕ά࡛⤒㦂ࡢ࠶ࡿ⮬↛࡞▱ぬࢆேᕤⓗ࡟ㄏⓎ࡛ࡁࠊ่⃭ࡢᙉᗘࢆኚ࠼ࡿࡇ࡜࡟ࡼࡾࠊ▱ぬࡢᙉࡉࡔࡅ࡛࡞ࡃ㉁ࢆࡶኚ࠼ࡽࢀࡿࡇ࡜ࢆぢฟࡋࠊ⮬↛࡞▱ぬࡢ෌ᘓࡀ࡛ࡁࡿྍ⬟ᛶࡀ♧ࡉ
ࢀࡓ㸦Frontiers in Neuroscience㸧ࠋពḧ୰ᯡ࡛࠶ࡿ୰⬻㎶⦕⣔ࡀ⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟ࢆಁࡍ
ࡓࡵࡢ⬻άື⏕ᡂ࡜ࢿࢵࢺ࣮࣡ࢡ෌⦅ࢆᢸࡗ࡚࠸ࡿࡇ࡜ࢆド᫂ࡋࡓ㸦Cerebral Cortex㸧ࠋA◊       ✲       ᡂ       ᯝE㸦༠ຊ◊✲ဨ㸧༡㒊 ⠜㸦⏕⌮Ꮫ◊✲ᡤ㸧▱ぢ⪽⨾㸦⏕⌮Ꮫ◊✲ᡤ㸧ව㔜⨾ᕼ㸦ி㒔኱Ꮫ㸧㧗ᶫ⌶ဢ㸦ᶓ὾ᕷ❧኱Ꮫ㸧㜿㒊ᘯᇶ㸦ᶓ὾ᕷ❧኱Ꮫ㸧୰ᓥ࿴ᕼ㸦ᶓ὾ᕷ❧኱Ꮫ㸧ᫍ㔝┿ே㸦࣍ࣥࢲ㸧኱⇃஧㑻㸦࣍ࣥࢲ㸧᳝ྡ࠶ࡍ㤶㸦࣍ࣥࢲ㸧ᫍ⏤㈡㔛㸦࣍ࣥࢲ㸧すᓥ඘ᓫ㸦࣍ࣥࢲ㸧Ⲉᮌᣅஓ㸦NTTࢹ࣮ࢱ㸧᱈ᮌ⨾Ⓩ㔛㸦NTTࢹ࣮ࢱ㸧ᑠụ ᬋ㸦NTTࢹ࣮ࢱ㸧㸦ᐈဨ◊✲ဨ㸧ᫍ ⱥྖ㸦ᮌ᭦ὠ⑓㝔㸧Ἑྜ୍Ṋ㸦᪥ᮏ኱Ꮫ㸧(2) ◊✲⪅ྡ
すᮧᖾ⏨
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◊✲ᮇ㛫
2017ᖺ4᭶㹼2020ᖺ3᭶
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⬻⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟ᶵᗎゎ᫂࡜ᶵ⬟෌ᘓἲࡢ㛤Ⓨ㸭⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸すᮧᖾ⏨㸧㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 18 －

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(3)ᅜෆእࡢ◊✲≧ἣ࣑ࢡࣟࢢࣜ࢔ࡢ◊✲ࡣ㏆ᖺ㛵ᚰࡀ㧗ࡲࡗ࡚࠸ࡿࡀࠊ⏕ᚋࡢ⬻࡟࠾ࡅࡿ࣑ࢡࣟࢢࣜ࢔ࡢືែ࡟ࡘ࠸࡚ࡣᅜෆእࢆ㏻ࡌ࡚◊✲ࡣ㐍ࢇ࡛࠸࡞࠸ࠋࡲࡓᛴᛶ⬻⑕ࠊከⓎᛶ◳໬⑕➼ࡢᑠඣࡢච␿ᛶ⚄⤒⑌ᝈ࡟ࡘ࠸࡚ࡶࠊᡂே㡿ᇦ࡜ẚ㍑ࡋ࡚◊✲ࡣ❧ࡕ㐜ࢀ࡚࠸ࡿࠋࡲࡓ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡢ⶝ᘏ࡟క࠸ࠊ
⚄⤒ྜే⑕࡟ࡘ࠸࡚᪩ᛴ࡟᳨ウࡍࡿᚲせࡀ࠶ࡿࠋㄽᩥᥖ㍕
࣭ Eur J Immunol, Brain Dev≉ู࣭ᩍ⫱ㅮ₇
࣭ Asian & Oceanian Congress of Child Neurology࣭ ᪥ᮏᑠඣ⚄⤒Ꮫ఍࣭ ᪥ᮏ࡚ࢇ࠿ࢇᏛ఍

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(1) ᡂᯝࡢᴫせձ ᇶ♏◊✲
1) in vitro࡟࠾ࡅࡿ࣑ࢡࣟࢢࣜ࢔෌ศᕸࡢᐇ㦂⣔ࢆ⏝࠸࡚࣑ࢡࣟࢢࣜ࢔ࡢ⏕Ꮡ࡜ศ⿣ቑṪ࡟㛵ࢃࡿヲ⣽࡞ศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡓࠋ2) P2Y12ࣉࣜࣥ࡟ADPࡀ⤖ྜࡍࡿ࡜K+࢖࢜ࣥࡢὶฟࢆ௓ࡋ࡚
⅖⑕ᛶࢧ࢖ࢺ࢝࢖ࣥ⏘⏕㈇࡟ไᚚࡍࡿࡇ࡜ࢆぢฟࡋࠊ
European Journal of Immunologyㄅ࡟Ⓨ⾲ࡋࡓࠋ3) ࢔ࢫࢺࣟࢧ࢖ࢺ࡟ࡼࡿࢢࣝࢱ࣑ࣥ㓟ྲྀࡾ㎸ࡳ⬟ࢆไᚚࡍࡿ⸆๣ࢆホ౯ࡍࡿࡓࡵ࡟in vitroࡢᐇ㦂⣔ࢆ☜❧ࡋࡓࠋ4) 㦵㧊⏤᮶ไᚚᛶ⣽⬊ࢆศ໬ㄏᑟࡋࠊp38MAPKࡢศ໬࡟࠾ࡅ
ࡿᙺ๭ࢆ᳨ウࡋࡓࠋ5) ప㓟⣲㈇Ⲵ࡜lipopolysaccharideᢞ୚ࡢే⏝࡟ࡼࡿࣛࢵࢺ⬻ᐊ
࿘ᅖⓑ㉁㌾໬⑕ࣔࢹࣝࢆసᡂࡋࡓࠋղ ⮫ᗋ◊✲
6) 㞴἞㢖ᅇ㒊ศⓎస㔜✚ᆺᛴᛶ⬻⅖ࡢ⑓ែゎ᫂◊✲ࢆ㐍ࡵࠊྠ⑌ᝈ࡟ᑐࡍࡿࢫࢸࣟ࢖ࢻ㧊ὀ⒪ἲࡢ᭷ຠᛶࢆ᳨ウࡋࡓࠋ7) ᵝࠎ࡞ᑠඣ⚄⤒⑌ᝈ࡟࠾ࡅࡿ㧊ᾮ୰⅖⑕ᛶࢧ࢖ࢺ࢝࢖ࣥࣉ
ࣟࣇ࢓࢖ࣝࢆ᳨ウࡋࡓࠋ8) ᢠMOGᢠయࡀ⿵య౫Ꮡᛶ࡟MOGⓎ⌧⣽⬊ࢆയᐖࡍࡿࡇ࡜ࢆド᫂ࡋࡓࠋ(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ᇶ♏◊✲࡛ࡣTRECKἲ࡟ࡼࡿࢢࣜ࢔⣽⬊୍㐣ᛶ㝖ཤࣔࢹࣝࢆ୰ᚰ࡟ࠊ࢔ࢫࢺࣟࢧ࢖ࢺ࡜࣑ࢡࣟࢢࣜ࢔ࡢin vivo◊✲ࢆຍ㏿ࡍࡿࠋࡲࡓᑠඣ⚄⤒⑌ᝈࡢື≀ࣔࢹࣝࢆ⏝࠸ࡓ◊✲࡟ຊࢆධࢀࡿࠋ࣭ ⮫ᗋ◊✲࡛ࡣࣂ࢖࣐࣮࣮࣭࢜࢝⮬ᕫᢠయ࡜⮫ᗋᡤぢ࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡋࠊࡉࡽ࡟᪂ࡓ࡞ᢠ⚄⤒ᢠయࡢ ᥈⣴ࢆヨࡳࡿࠋࡲࡓ᪂ᆺࢥࣟࢼ࢘࢖ࣝࢫឤᰁ⑕ࡢ⚄⤒ྜే⑕࡟㛵ࡍࡿ⮫ᗋ◊✲ࢆ㛤ጞࡍࡿࠋᴫせձ ᇶ♏◊✲1) ࣑ࢡࣟࢢࣜ࢔ࡢ෌ศᕸࣔࢹࣝࢆ⏝࠸ࡓࢢࣜ࢔⣽⬊ࡢᩘⓗᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂, 2) P2Y12ࣉࣜࣥཷᐜయࡀ࣑ࢡࣟࢢ
ࣜ࢔ࡢᶵ⬟࡟ཬࡰࡍᙳ㡪, 3 ) ࢔ࢫࢺࣟࢧ࢖ࢺ࡟ࡼࡿࢢࣝࢱ࣑
ࣥ㓟ࢫ࢝࣋ࣥࢪࡢไᚚ, 4) 㦵㧊⏤᮶ไᚚᛶ⣽⬊ࡢศ໬ㄏᑟ, 5)ࣛࢵࢺ⬻ᐊ࿘ᅖⓑ㉁㌾໬⑕ࣔࢹࣝࡢసᡂղ ⮫ᗋ◊✲
6) 㞴἞㢖ᅇ㒊ศⓎస㔜✚ᆺᛴᛶ⬻⅖ࡢ⑓ែゎ᫂, 7)ᑠඣ⚄⤒⑌ᝈ࡟࠾ࡅࡿ᪂つࣂ࢖࣐࣮࣮࢜࢝ࡢ᥈⣴࡜⑓ែゎ᫂, 8) ⅖⑕ᛶ⚄⤒⑌ᝈ࡜ᢠ⚄⤒ᢠయ

(1)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ

◊✲ᮇ㛫

◊✲⪅ྡ

ῄᚨ኱Ꮫ
ᯘ 㞞ᬕᮾி኱ᏛⓎ㐩་⛉Ꮫ
ᫍ㔝 ឡ

⇃⏣⪽Ꮚ

ᮾி㒔❧⚄⤒⑓㝔⚄⤒ᑠඣ⛉

⬻Ⓨ㐩࣭⚄⤒෌⏕◊✲ศ㔝
బஂ㛫ၨ
ᯇᒸ㈗Ꮚ
⚄ᒣ㑥Ꮚ
㕥ᮌᬛ඾
ᇼ㔝ᮅᏊ
す⏣⿱ဢ
᳃ᒣ๢ග
⸨⏣ᇶ㈨
ከ⏣ᘯᏊ

ᮾி㒔❧ᗓ୰⒪⫱ࢭࣥࢱ࣮
ᑠඣ⛉
⚟Ỉ㐨㑻
⏣἟┤அ

ᮾி໭♫఍ಖ㝤⑓㝔ᑠඣ⛉
ᐑ⏣⌮ⱥ


(2)

2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

(1)

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
ࡇ࡝ࡶࡢ⬻࡟࠾ࡅࡿ⎔ቃ⥔ᣢᶵᵓࡢゎ᫂㸭ࡇ࡝ࡶࡢ⬻ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸బஂ㛫ၨ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 19 －



(3)ᅜෆእࡢ◊✲≧ἣୖグࡢ⑓ែࢆ◊✲ࡋ࡚࠸ࡿ◊✲ᐊࡣᅜෆእ࡟ᩘከࡃ࠶ࡿ
ࡀࠊศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋࠊࡑࢀ࡟ᇶ࡙࠸࡚἞⒪⸆ࢆ᥈⣴ࡋ࡚࠸ࡿ◊✲ᐊࡣୡ⏺ⓗ࡟ࡶᩘ࠼ࡿ⛬࡛࠶ࡿࠋࡲࡓࠊ
ከࡃࡀୡ⏺ࢺࢵࣉࣞ࣋ࣝࡢ◊✲ᐊ࡛࠶ࡿࠋ

࣭(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ୖグࡢ⤖ᯝ࠿ࡽࠊRheb㜼ᐖ⸆ࡀTSC࡟ྜేࡍࡿ▱ⓗ㞀ᐖࡸ⮬㛢⑕࡟᭷ຠ࡞ྍ⬟ᛶࡀ࠶ࡿࠋᮏㄢ㢟ࡣࠊAMED㞴἞ᛶ⑌ᝈᐇ⏝໬◊✲஦ᴗ࡟᥇ᢥࡉࢀࡓࡓࡵࠊ௒ᚋࡣᐇ⏝໬࡟ྥࡅ࡚ࠊಙ㢗ᛶᇶ‽ࡢ⸆ຠ⸆⌮ヨ㦂ࡸࣂ࢖࣐࣮࣮࢜࢝ࡢ᥈⣴ ࢆ⾜࠺ ணᐃ࡛࠶ࡿࠋ

ղ Rheb㜼ᐖ⸆ᢞ୚࡟ࡼࡿࠊTsc2+/-࣐࢘ࢫࡢᅇ㊰ືែࡢᅇ᚟
グ᠈࡟㛵ࢃࡿ⚄⤒⣽⬊ࢆྠᐃࡋࠊࡑࡢάືࡸࢩࢼࣉࢫᙧែࢆほᐹࡍࡿࡓࡵࠊάື౫Ꮡⓗ࡟EGFPࢆⓎ⌧ࡍࡿ࢔ࢹࣀ㝶క࢘࢖ࣝࢫ㸦AAV㸧ࢆ࣐࢘ࢫᾏ㤿࡟ὀධࡋࡓࠋࡑࡋ࡚ࠊグ㖭ࡸ᝿㉳࡟కࡗ࡚άືࡍࡿࢽ࣮ࣗࣟࣥ㸦⑞㊧⣽⬊㸻࢚ࣥࢢ࣒ࣛ㸧ࢆᶆ㆑ࡋࠊ
㔝⏕ᆺ࡜Tsc2+/-࣐࢘ࢫ㛫࡛ẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝࠊ㔝⏕ᆺ࡛ࡣ᝿㉳࡟కࡗ࡚グ᠈⑞㊧⣽⬊ࡀቑຍࡋࡓࡀࠊTsc2+/-࣐࢘ࢫ࡛ࡣ᭷ព࡞ቑຍࡣぢࡽࢀ࡞࠿ࡗࡓࠋࡑࡇ࡛ࠊTsc2+/-࣐࢘ࢫ࡟Rheb㜼ᐖ⸆ࢆᢞ୚
ࡍࡿ࡜ࠊグ᠈⑞㊧⣽⬊ࡀቑຍࡋࠊࢫࣃ࢖ࣥᐦᗘࡶቑຍࡋࡓࠋࡍ
࡞ࢃࡕࠊRheb㜼ᐖ⸆࡟ࡼࡗ࡚Tsc2+/-࣐࢘ࢫࡢࢩࢼࣉࢫࡀᅇ᚟ࡋࠊᅇ㊰ືែࡀᨵၿࡍࡿࡓࡵࠊグ᠈ࡀᅇ᚟ࡍࡿ࡜⪃࠼ࡽࢀࡓࠋ

࣭

࣭
࣭
࣭

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
Int J Mol Sci. 20(17), 2019..
Sci Rep. 9(1):14852, 2019.
21st TMIMS International Symposium “Overcoming
neuropsychopharmacology crisis”. (2019-10-15 Tokyo)
20th TMIMS International Symposium ”Principles of
Neocortical Development and Evolution”. (2019-7-30 Tokyo)
62nd Annual Meeting of the Japanese Society for
Neurochemistry. (2019-7-25 Niigata)ᡂᯝࡢᴫせձ ࣄࢺTSC⚄⤒⣽⬊ࡢసᡂ࡜Rheb㜼ᐖ⸆ࡢຠᯝࣄࢺiPS⣽⬊ࡢTsc2㑇ఏᏊ࡟ࠊCRISPR/Cas9ἲࢆ⏝࠸࡚ኚ␗ࢆᑟ
ධࡋࠊࣄࢺTSC⣽⬊ࢆసᡂࡋࡓࠋࡑࢀࢆ⚄⤒⣽⬊࡬ศ໬ࡉࡏࠊࡑ
ࡢᙧែࢆ㔝⏕ᆺ࡜ẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝࠊTsc2-/-ࢽ࣮ࣗࣟࣥࡣࠊ㔝⏕ᆺ࡟ẚ࡭࡚⣽⬊యࡀ኱ࡁࡃࠊ⣽⬊య࠿ࡽఙࡧࡿᶞ≧✺㉳ࡢᮏᩘࡶከ࠿ࡗࡓࠋࡉࡽ࡟㛗ᮇᇵ㣴ࡍࡿ࡜㸦282᪥㸧ࠊ㔝⏕ᆺࢽ࣮ࣗࣟࣥ࡟
ࢫࣃ࢖ࣥᵝࡢᵓ㐀ࡀㄆࡵࡽࢀࡓࡀࠊTsc2-/-ࢽ࣮࡛ࣗࣟࣥࡣ࡯࡜ࢇ࡝
ࢫࣃ࢖ࣥᵝᵓ㐀ࡣぢࡽࢀ࡞࠿ࡗࡓࠋࡉࡽ࡟ࠊ࢝ࣝࢩ࣒࢘࢖࣓࣮ࢪ
ࣥࢢࢆ⾜ࡗࡓ࡜ࡇࢁࠊTsc2-/-ࢽ࣮࡛ࣗࣟࣥࡣྠᮇࡋࡓ⮬ⓎⓎⅆࡀ㢖ᅇ࡟ほᐹࡉࢀࠊ࡚ࢇ࠿ࢇⓎసࢆ෌⌧ࡋ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡓࠋ
(1)

ᴫせࠕࢩࢼࣉࢫࠖࡣ⚄⤒⣽⬊ྠኈࡢ᥋ྜ㒊࡛࠶ࡾࠊࢩࢼࣉࢫࡀ
ṇࡋࡃᙧᡂࡉࢀ࡞࠸࡜⬻ࡶṇᖖ࡟ᶵ⬟ࡋ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡ
ࢺ࡛ࡣࠊࢩࢼࣉࢫྍረᛶࡢ␗ᖖ㸦㞴἞࡚ࢇ࠿ࢇࡸ⢭⚄㐜⁫ࠊ⮬㛢⑕࡞࡝㸧ࢆᑐ㇟࡜ࡋࠊࡑࡢ⑓ែ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜࡟ࡼࡾ᭷ຠ࡞἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ

(1)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾᯇᮧ ₩㸦኱㜰ᕤ኱㸧ዟᮧᙲஂ㸦ឡ▱་኱㸧㸦㡰ኳᇽ኱㸧⏣୰⚽࿴㸦❧࿨㤋኱㸧➉ᐑᏕᏊ㸦ᮾிዪᏊ་኱㸧ᑠᯘᩄஅࠊᵽ㔝⯆ኵ(2) ◊✲⪅ྡ
ᒣᙧせே
ஂᜏᬛ༤
ᓥ⏣ᛅஅ
ᮡᾆᘯᏊ
ᏲᒇᩗᏊ
Ᏻ⏣ ᪂
᪂஭ಙ㝯㸦⚄⤒⑓⌮ゎᐊ㸧᱇ᯘ⚽ኴ㑻㸦⚟ᒸ኱㸧ᚋ⸨⣧୍ࠊ⸨ཎᾈᶞࠊ
⸨஭ ⪽㸦ᒣᙧ኱㸧(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
ࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡜⑌ᝈ㸭ࢩࢼࣉࢫྍረᛶࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᒣᙧせே㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 20 －

(1)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊       ✲       ᡂ       ᯝ(2) ◊✲⪅ྡᒸᡞᬕ⏕ᖹ஭ᚿఙ⏣୰ᬛᏊ㸦2016.4 ╔௵㸧ᖹ஭Ύ⳹ (2014.6 ㌿ฟ)㧗ᶫள⣖௦㸦2011.5 ㌿ฟ㸧Ỉ㔝୍ஓ㸦2011.3 ㌿ฟ㸧୰⏣࿴Ꮚ㸦2011.3 ㌿ฟ㸧୸ᒣ༓⛅㸦2013.3 ㌿ฟ㸧୕㍯᫛Ꮚ㸦2016.4 ㏥⫋㸧(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
⚄⤒⣽⬊ࡢศ໬࣭⏕Ꮡ࡜ࡑࡢ㞀ᐖࡢศᏊᶵᵓ㸭⚄⤒⣽⬊ศ໬ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᒸᡞᬕ⏕㸧(1) ᡂᯝࡢᴫせ࣭ RP58ࡢࢽ࣮ࣗࣟࣥⓎ㐩࡟࠾ࡅࡿᶵ⬟ⓗព⩏ࡢゎ᫂:▱ⓗ㞀ᐖඣࡢ࢚ࢡࢯ࣮࣒ゎᯒ࡟ࡼࡾࠊRP58ࡢࢼࣥࢭࣥࢫኚ␗ࠊ࣑ࢫࢭࣥ
ࢫኚ␗ࢆ࣐࢘ࢫࡢ኱⬻⓶㉁࡟ᑟධࠊᶵ⬟␗ᖖࢆྠᐃࡋࡓࠋ
࣭ RP58ࡢ⬻⭘⒆࡟ᑐࡋ࡚ᢚไⓗ࡟స⏝ࡍࡿࡇ࡜࠿ࡽࡑࡢࢱ࣮ࢤ
ࢵࢺࢆ᥈⣴ࡋࠊTGFbཬࡧࡑࡢཷᐜయࠊPDGFཬࡧࡑࡢཷᐜయࡀ
ࢱ࣮ࢤࢵࢺ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓࠋ
࣭ ㉁㔞ศᯒჾࢆ⏝࠸࡚ࠊRP58࡜⤖ྜࡍࡿ⺮ⓑࠊ Ctbp㸯ࢆྠᐃ
ࡋࠊRP58ࡢCtbp1⤖ྜ㒊఩ࢆኚ␗ࡉࡏࡿ࡜㌿෗ᢚไάᛶࡀ༙ῶ
ࡋࠊࢽ࣮ࣗࣟࣥ⛣ືࠊᡂ⇍ࢆ㞀ᐖࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ཎ⣴ື≀ࢆ⏝࠸࡚ࠊAMPAᆺGluཷᐜయࡀࠊᯇᯝయᵝගཷᐜჾ࣭ EMBO Jᐁᙧᡂࠊኚែ࡟ᚲせ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭ Neuroscience࣭ ẕᏊศ㞳ࢫࢺࣞࢫ࡟ࡼࡾ⾑⟶㞀ᐖࡀぢࡽࢀࠊAPPኚ␗࣊ࢸ࣐ࣟ
࣭ Cell Report࢘ࢫ࡛ࡣࡉࡽ࡟BBBࡢ◚⥢ࠊ࢔࣑ࣟ࢖ࢻ࣮࣋ࢱ⵳✚ࠊㄆ▱ᶵ⬟࣭ Cerebral Cortex
࣭ PNASపୗࡀぢࡽࢀࡓࠋ࣑ࢡࣟࢢࣜ࢔ࡢึᮇኚ໬ࢆྠᐃࡋࡓࠋ
࣭ Brain Research࣭ 㞳ஙᚋࢩࣙ⢾ࢫࢺࣞࢫ࡛ࡣࠊAGEࡢ⾑⟶ෆ⾑⵳✚ࡀぢࡽࢀࠊࡉ࣭ BioEssays
ࡽ࡟Glo1࣊ࢸ࣐ࣟ࢘ࢫ࡛ࡣࠊ⾑⟶ෆࣇ࢕ࣈࣜࣥ⵳✚ࠊ⢭⚄⑌ᝈ࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍ᵝ␗ᖖࢆ♧ࡋࠊྠࡌ⾑⟶㞀ᐖࢆᝈ⪅ࡢ࠺࡛ࡶྠᐃࡋࡓࠋ࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍࣭ RP58࣊ࢸ࣐ࣟ࢘ࢫࡣDNAᦆയࠊ࣑ࢡࣟࢢࣜ࢔ࡢάᛶ໬➼ࠊ⬻࣭ ᪥ᮏ⏕⌮Ꮫ఍ࡢ⪁໬ᣦᶆࢆ᪩ᮇ࡟♧ࡍࠋ࣭ ⤫ྜኻㄪ⑕Ꮫ఍
࣭ RP58Ⓨ⌧ࢆtetO⣔࡛ேⅭⓗ࡟ไᚚࡋࠊⓎ⌧㔞ࡀㄆ▱ᶵ⬟ࢆつᐃࡋ࡚࠸ࡿࡇ࡜ࢆᐇドࡋࡓ㸦≉チฟ㢪㸧ࠋ(3) ᅜෆእࡢ◊✲≧ἣ
࣭ APPኚ␗࣐࣍ࣔ࢘ࢫ࡟RP58Ⓨ⌧࢔ࢹࣀ㝶క࢘࢖ࣝࢫࢆ⤒㟼⬦ⓗHeng༤ኈ㸦࣮࢜ࢫࢺࣛࣜ࢔ࠊඹྠ◊✲⪅㸧ࡣRP58ࡀRnd2ࢆ
࡟ᢞ୚ࡋࡓ࡜ࡇࢁࠊㄆ▱ᶵ⬟ࡀᨵၿࡋࡓࠋ
௓ࡋ࡚ᨺᑕ≧⛣ືࢆྖࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
࣭ RP58ࢆᑠ⬻ࡢࣂࢫࢣࢵࢺ⣽⬊࣭ᫍ≧⣽⬊ࡢࡳ࡛Ḟⴠࡉࡏࡿึ
ࡵ࡚ࡢ࣐࢘ࢫࡢసᡂ࡟ᡂຌࡋࡓࠋㄆ▱ᶵ⬟㞀ᐖࢆ♧ࡋࠊᑠ⬻⑌ᝈ࡟ࡼࡿㄆ▱ᶵ⬟㞀ᐖࡢࣔࢹ࣐ࣝ࢘ࢫ࡜࡞ࡿࠋ
(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ RP58ࡢ᭦࡞ࡿୗὶᅉᏊࠊRP58࡜⤖ྜࡍࡿ⺮ⓑࢆ⥙⨶ⓗ࡟ྠᐃࡋࠊࢽ࣮ࣗࣟࣥࡢ⏕Ꮡࠊᡂ⇍࡟ᚲ㡲࡛࠶ࡿศᏊ࣓࢝ࢽࢬ࣒ࢆ᫂
ࡽ࠿࡟ࡍࡿࠋᰤ㣴ࠊẕᏊศ㞳ࢫࢺࣞࢫࡀ⬻Ⓨ㐩࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋࠊ⢭⚄㞀ᐖࠊㄆ▱㞀ᐖ࡬ࡢ㛵୚ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᴫせPOKᆺ㌿෗ᢚไᅉᏊRP58ࡀࢽ࣮ࣗࣟࣥ๓㥑⣽⬊ࡢ⣽⬊࿘ᮇ㞳⬺ࠊᨺᑕ≧⛣ື࡟ᚲ㡲࡛࠶ࡿࡇ࡜࡜ࠊࡑࡢศᏊ࣓࢝ࢽࢬ࣒
ࢆ᫂ࡽ࠿࡟ࡋ࡚ࡁࡓࠋࡉࡽ࡟ྛࠎࡢゎᯒࢆࡍࡍࡵࠊRP58ࡀ⬻⭘⒆ࡢቑṪ࡜ᝏᛶ໬ࡢ୧⪅ࢆᢚไࡍࡿࡇ࡜ࠊࡲࡓRP58ࡣᡂ⇍ࢽ࣮ࣗࣟࣥ࡟࠾ࡅࡿᶵ⬟ⓗព⩏ࢆ᫂ࡽ࠿࡟ࡋࡘࡘ࠶ࡿࠋࡉࡽ
࡟ࠊᰤ㣴⎔ቃࠊẕᏊศ㞳ࢫࢺࣞࢫࡀ⬻ࡢⓎ㐩࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋࡘࡘ࠶ࡿࠋ

୺࡞◊✲ᡂᯝ 

－ 21 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ㏆ᖺࠊࢩࢼࣉࢫᙧᡂࡸ⚄⤒⣽⬊⛣ື࡞࡝⚄⤒ᅇ㊰ᙧᡂࡢึᮇ㐣⛬ࡢ␗ᖖࡀࠊᵝࠎ࡞⢭⚄࣭⚄⤒⑌ᝈࡢཎᅉ࡟࡞ࡿࡇ࡜ࡀ
᫂ࡽ࠿࡟ࡉࢀࡘࡘ࠶ࡿࠋᚑࡗ࡚ࠊࡇࢀࡽࡢ⑌ᝈࡢ⑓ᅉࢆゎ᫂ࡋࠊ㐺ษ࡞἞⒪ἲࢆ㛤Ⓨࡍࡿࡓࡵ࡟ࡣࠊ⚄⤒ᅇ㊰ᙧᡂࡢᇶ♏
ⓗ࡞ศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࡀᚲ㡲࡛࠶ࡿࠋ㏆ᖺࠊࣉࣟࢸ࢜ࢢࣜ࢝ࣥࢆጞࡵ࡜ࡍࡿ⣽⬊እᇶ㉁ࡀࠊ⚄⤒ᅇ㊰ᙧᡂ࡟㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿࡇ࡜ࡀㄆ㆑ࡉࢀࠊࡑࡢᶵ⬟࡜స⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂ࡀᮇᚅࡉࢀ࡚࠸ࡿࠋ࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍(1)◊       ✲       ᡂ       ᯝ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚NMJࡢ⤒㦂౫Ꮡᆺྍረᛶࡀ࡝ࡢࡼ࠺࡞᝟ሗఏ
㐩⤒㊰࡟ࡼࡗ࡚ไᚚࡉࢀ࡚࠸ࡿࡢ࠿ࠊࡑࡢヲ⣽࡞ศᏊ࣓࢝ࢽࢬ
࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࠋࢩࣙ࢘ࢪࣙ࢘ࣂ࢚NMJࡣࠊᵝࠎ࡞⚄⤒ኚᛶ⑌ᝈࡢࣔࢹࣝ࡜ࡋ࡚⏝࠸ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ࡣࡑࢀࡽ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែゎ᫂࡟ࡘ࡞ࡀࡿࠋ࣭ ᨺᑕ≧⚄⤒⣽⬊⛣ື࡟కࡗ࡚኱ࡁ࡞Ⓨ⌧ኚ໬ࢆ♧ࡍ⣽⬊እᇶ㉁ᡂศཬࡧࢩࢼࣉࢫ㛵㐃ศᏊ࡟ࡘ࠸࡚ࠊࡑࡢ⣽⬊⛣ືไᚚ࡟࠾ࡅ
ࡿᶵ⬟ࢆࠊ࣐࢘ࢫᏊᐑෆ⫾௘㟁Ẽ✸Ꮝἲ➼ࢆ⏝࠸࡚ヲ⣽࡟ゎᯒࡍࡿࠋᨺᑕ≧⚄⤒⣽⬊⛣ືࡢ␗ᖖࡣࠊ⁥⬻⑕➼ࡢ⬻ወᙧࠊࡉࡽ
࡟⤫ྜኻㄪ⑕ࡸ⮬㛢⑕➼ࡢ⢭⚄⑌ᝈࡢཎᅉ࡟࡞ࡿ࡜⪃࠼ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ࡣࡇࢀࡽࡢ⑌ᝈࡢ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡀࡿࠋ

(2)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ㸦࠾ⲔࡢỈዪᏊ኱኱Ꮫ㝔㸧

࣭◊ಟ⏕
㔠Ꮚ஀ឡ
୸ ᬛ㤶Ꮚ

࣭◊✲ᢏ⾡ဨ ᖹ஭ஂ⨾Ꮚ ᑠ⏣ᔱឡᏊ

㸦ி㒔ᗓ❧་኱㸧㔝ᮧ ┿㸦࠾ⲔࡢỈዪᏊ኱㸧(2) ◊✲⪅ྡ
࣭◊✲ဨ
๓⏣ಙ᫂
୸ᒣ༓⛅
⚄ᮧᆂு

࣭ᐈဨ◊✲ဨ⏤Ⰻ ᩗ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
⚄⤒ᅇ㊰ࡢᙧᡂ࡜ࡑࡢⓎ㐩␗ᖖࡢ࣓࢝ࢽࢬ࣒㸭⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୸ᒣ༓⛅㸧ᴫせ(1) ᡂᯝࡢᴫせ⚄⤒ᅇ㊰ࡢᙧᡂ࡜ࡑࡢⓎ㐩␗ᖖࡢศᏊᶵᵓࢆࠊࣉࣟࢸ࢜ࢢ ձ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⚄⤒ᅇ㊰ᙧᡂ࡟࠾ࡅࡿࣉࣟࢸ࢜ࢢ
ࣜ࢝ࣥࡢᶵ⬟ゎᯒࣜ࢝ࣥࢆጞࡵ࡜ࡍࡿ⣽⬊እᇶ㉁࡟ὀ┠ࡋ࡚ゎ᫂ࡋࠊᚓࡽࢀࡓ
࣭ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᗂ⹸ࡣ㣚㣹≧ែ࡟㝗ࡿ࡜άⓎ࡟⛣ືࡍࡿࡼ࠺
▱ぢࢆ㍈⣴෌⏕ࡸ⢭⚄࣭⚄⤒⑌ᝈࡢ἞⒪ᡓ␎࡬࡜ᛂ⏝ࡍࡿࡇ࡟࡞ࡿࡀࠊࡑࢀ࡜ඹ࡟⚄⤒➽᥋ྜ㒊㸦NMJ㸧࡟࠾ࡅࡿࢩࢼࣉࢫ
࡜ࢆ┠ᣦࡍࠋ
࣎ࢱࣥࡢ᪂⏕ࡀㄏᑟࡉࢀࡿ㸦⤒㦂౫Ꮡᆺྍረᛶ㸧ࠋᮏᖺᗘࡣࠊ
࣊ࣃࣛࣥ◲㓟ࣉࣟࢸ࢜ࢢࣜ࢝ࣥࡢ୍ࡘࢢࣜࣆ࢝ࣥࡀࠊBMPࢩࢢ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ࢼࣝࢆᢚไࡍࡿࡇ࡜࡟ࡼࡗ࡚⤒㦂౫Ꮡᆺྍረᛶࢆไᚚࡋ࡚࠸ࡿ
࣭ Scienceࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࠊㄽᩥࢆCell Reports࡟Ⓨ⾲ࡋࡓࠋ࣭ Journal of Cell Biologyղ ࣐࢘ࢫ኱⬻⓶㉁ᙧᡂ࡟࠾ࡅࡿ⚄⤒⣽⬊⛣ືࡢไᚚᶵᵓ
࣭ Cell Reports࣭኱⬻᪂⓶㉁ࡢ⯆ዧᛶࢽ࣮ࣗࣟࣥࡣࠊ⓶㉁῝㒊࡛ㄌ⏕ࡋࡓᚋࠊ࣭ Development⬻⾲࡟ྥ࠿ࡗ࡚㡰ḟ⛣ືࡋ࡚࠸ࡃ㸦ᨺᑕ≧⚄⤒⣽⬊⛣ື㸧ࠋ࣭ Frontiers in Neuroscienceࡇࢀࡲ࡛࡟ࢃࢀࢃࢀࡣࠊࢧࣈࣉ࣮ࣞࢺᒙࡀ⚄⤒⣽⬊⛣ືࡢไ࣭ Frontiers in Neuroanatomyᚚ࡟㔜せ࡞ാࡁࢆࡋ࡚࠸ࡿ᪂つࡢ࣓࢝ࢽࢬ࣒ࢆⓎぢࡋㄽᩥࢆ࣭ Biochim Biophys Acta.
Science ࡟Ⓨ⾲ࡋࡓ(2018 ᖺ 4 ᭶)ࠋ௒ᖺᗘࡣࠊࢧࣈࣉ࣮ࣞࢺᒙ࣭ ᪥ᮏ⏕໬Ꮫ఍
࡟Ꮡᅾࡍࡿ⣽⬊እᇶ㉁ࡢᙺ๭ࢆㄪ࡭ࠊ ࣉࣟࢸ࢔࣮ࢮ࡛࠶ࡿ࣭ ໭⡿⚄⤒⛉Ꮫ఍
ADAMTS2 ࡀ⚄⤒⣽⬊⛣ືไᚚ࡟㔜せ࡞ᶵ⬟ࢆᯝࡓࡍࡇ࡜ࢆ࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍ぢฟࡋ⌧ᅾㄽᩥᢞ✏‽ഛ୰࡛࠶ࡿࠋ࣭ ᪥ᮏ⏕⌮Ꮫ఍୺࡞◊✲ᡂᯝ 

－ 22 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

A

E

◊
       ✲       ᡂ       ᯝ(3)ᅜෆእࡢ◊✲≧ἣ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࣉࣟࢪ࢙ࢡࢺࡣࢃࡀᅜึ࡛࠶ࡾࠊ
ᛮ᫓ᮇࢆ⦪᩿㏣㊧ࡋࠊ⢭⚄⑓⌮➼ࡢᙧᡂࣉࣟࢭࢫ࡟ᙳ㡪ࢆ୚࠼ࡿせᅉ➼ࢆゎ᫂ࡍࡿព⩏ࡣ኱ࡁ࠸ࠋㄆ▱⑕ࡢேࡢ⾜ືᚰ⌮⑕≧ࡢᑐᛂ࡜┳ྲྀࡾࢆᨭ࠼ࡿࢣ࢔ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨࡣྛᅜㄆ▱⑕᪋⟇ࡸ◊✲ࡢ↔Ⅼ࡜࡞ࡗ࡚࠸ࡿࡀࠊᡃࡀᅜ࡛ྲྀࡾ⤌ࢇ࡛࠸ࡿᶵ㛵ࡣஈࡋ࠸ࠋ⿕⅏ఫẸࡢ࣓ࣥࢱࣝ࣊ࣝࢫࡢ⤒᫬ⓗኚ໬ࢆ㋃ࡲ࠼ࠊ
᫬ᮇ࡟ᛂࡌࡓᨭ᥼ㄢ㢟ࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࡣࠊᮾி㒔࡛ࡢ኱つᶍᆅ㟈ࡀண᝿ࡉࢀࡿ⌧≧࡟࠾࠸࡚ព⩏ࡀ኱ࡁ࠸ࠋ

(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Ando S & Nishida A et al (2019) Int J Epidemiol. 48:1414-1414g.
࣭ Nishida A et al (2018) J Psychiatr Res, 102: 136-141.
࣭ Yamasaki S et al (2019) Schizophr Res, 206: 52-57.
࣭ Naknishi M et al (2018) J Alzheimers Dis 64: 515-523.
࣭ Ando S et al (2019) PLoS One 14: e0214359.
࣭ Iijima Y et al (2019) J Affect Disord 246: 89-95.
࣭ Hirooka K et al (2020) Cogent Med 5: e1483097.
࣭ Morimoto Y et al (2018) BMJ Open 8: e020586.
࣭ Ando S & Nishida A et al (2018) J Affect Disord 238: 359-365.
࣭ Shimodera S & Nishida A et al (2018) Schizophr Res 201: 294-298.
࣭ Nakanishi M et al (2019) BJPsych Open 5: e10
࣭ Okada N et al (2019) Sci Rep 9(1): 732(1)ࡓࠋ12ṓ᫬ࠊ13ṓ᫬ࡢ୧᫬Ⅼ࡛࣌ࣥࢺࢩࢪࣥ⃰ᗘࡀప࠸⩌࡛ࡣࠊᗁ⫈య㦂⋡ࡀࢮࣟ㸣࡛࠶ࡗࡓࡢ࡟ᑐࡋࠊ୧᫬Ⅼ࡛㧗࠸⩌࡛ࡣࡑࢀࡀ
30%࡟ࡶཬࡪࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࡢࡇ࡜࠿ࡽᛮ᫓ᮇࡢ࣌ࣥࢺ
ࢩࢪࣥࡢ⦪᩿㌶㊧ࡀᗁ⫈ࢆண ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ࣭ ㄆ▱⑕ࡢேࡢᅾᏯ⏕άࢆᨭ᥼ࡍࡿࢣ࢔ࣔࢹࣝࡢ㛤Ⓨ㸸᫖ᖺᗘࡲ࡛࡟ຠᯝ᳨ドࢆ᏶஢ࡋࡓㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛࢆ඲㒔ⓗ࡟ᬑཬࡍࡿࡓࡵ
࡟㸦ᮾி㒔ᐇ⾜ࣉࣛࣥ㸧ࠊᮾி㒔ࡸ⮬἞య࡜㐃ᦠࡋ࡚ㄝ᫂఍ࠊ◊ಟ఍➼ࢆ✚ᴟⓗ࡟⾜ࡗࡓࠋඵ⋤Ꮚᕷࠊୡ⏣㇂༊ࠊ㊊❧༊ࢆࡣࡌࡵィ11ࡢ⮬἞యࡀ◊ಟ఍࡟ཧຍࡋࠊ㸰ᖺ㛫࡛⣙450ྡࡢᐇ㊶⪅ࢆ㣴ᡂࡋࡓࠋࡲࡓࠊ༓ⴥ┴࣭ᇸ⋢┴࣭⚄ዉᕝ┴ࡢ௓ㆤ஦ᴗᡤࢆᑐ㇟࡜ࡋࡓ㏣ຍ᳨
ド࡟࠾࠸࡚ࡶᮾி㒔࡟࠾ࡅࡿᐇ㊶࡜ྠᵝࡢຠᯝࡀ☜ㄆࡉࢀࡓࠋ࣭ ⢭⚄⛉࣏ࢫࢺᩆᛴࡢࢣ࢔ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨ㸸๓ᖺᗘࡲ࡛ࡢどᐹㄪᰝ➼ࡢᡂᯝࢆ㋃ࡲ࠼ࠊ⢭⚄⛉⑓㝔ࡢ་⒪ᚑ஦⪅ࢆᑐ㇟࡜ࡋࡓࢺ࣐ࣛ࢘
࣭࢖ࣥࣇ࢛࣮࣒ࢻ࣭ࢣ࢔㸦TIC㸧ࣉࣟࢢ࣒ࣛࢆ㛤Ⓨࡋࠊ㒔ෆࡢ⢭⚄⛉⑓㝔ࢫࢱࢵࣇ65ྡࢆᑐ㇟࡜ࡋࡓຠᯝ᳨ド◊✲ࢆᐇ᪋ࡋࡓࠋ⤖ᯝࠊ௓ධຠᯝࡢᣢ⥆ᛶࡀ☜ㄆࡉࢀࠊᅜ㝿Ꮫ⾡ㄅ࡟ሗ࿌ࡋࡓࠋ࣭ ⿕⅏⪅➼ࡢ⢭⚄ⓗ೺ᗣணᚋ࡟㛵ࡍࡿࢥ࣮࣍ࢺ◊✲㸸⿕⅏ᆅ୍⯡ఫẸ⢭⚄ಖ೺ࢥ࣮࣍ࢺ◊✲ࠊᛴᛶෙ⑕ೃ⩌ࢥ࣮࣍ࢺ◊✲࡜ࡶ࡟୍᫖ᖺᗘ
ࡲ࡛࡟ᙜึࡢ◊✲ィ⏬࡜ㄽᩥ໬సᴗࢆ㐩ᡂࡋ᏶஢ࡋ࡚࠸ࡿࠋ
(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࡢ10࣭12࣭14ṓ᫬ࢹ࣮ࢱࢆ㐃⤖ࡉࡏࠊ⦪᩿ࢹ࣮ࢱゎᯒࠊࡑࢀ࡟ᇶ࡙ࡃㄽᩥ໬ࢆ㐍ࡵࡿࠋ16ṓ᫬ㄪᰝࢆ╔ᐇ࡟㐍ࡵࡿࠋㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛࡢᬑཬ࡟ྥࡅࡓe-࣮ࣛࢽࣥࢢ࡟ࡼࡿ
ᒎ㛤ࢆᮾி㒔࠾ࡼࡧ༠ຊ⮬἞య࡜㐃ᦠࡋ࡚᥎㐍ࡍࡿࠋ

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦㐃ᦠ◊✲ဨ㸧
ྂᕝኖு
ᕝୖ᠇ே
➟஭ΎⓏ
బࠎᮌྖ
Ᏹబ⨾្
㐍⸨⏤⨾
ᐑᮏ᭷⣖

㸦༠ຊ◊✲ဨ㸧⟄஭༟ᐇ(2) ◊✲⪅ྡ
す⏣῟ᚿ
ᒣᓮಟ㐨
୰す୕᫓
ዟᮧὈஅ
᪂ᮧ㡰Ꮚ
㐲⸨㤶⧊
㣤ᓥ㞝኱
ᘅᒸె௦
Ᏻ⸨ಇኴ㑻㸦ᐈဨ㸧ᑠụ㐍௓㸦ᐈဨ㸧㣕㫽஭ᮃ㸦ᐈဨ㸧(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾᚰࡢ೺ᗣ࡙ࡃࡾࡢࡓࡵࡢண㜵࣭἞⒪࣭ࣜࣁࣅࣜἲ㸭ᚰࡢ೺ᗣࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸す⏣῟ᚿ㸧ᴫせ(1) ᡂᯝࡢᴫせᚰࡢ೺ᗣࡣࠊಶேࡢ⏕άࡢ㉁ࢆ኱ࡁࡃᕥྑࡍࡿࠋࡇ࡜࡟኱㒔 ࣭ ᛮ᫓ᮇ࣓ࣥࢱࣝ࣊ࣝࢫ࡜࢙࣭࢘ࣝࣅ࣮࢖ࣥࢢࡢᐤ୚ᅉᏊゎ᫂㸸㒔ෆ3⮬἞య࡜㐃ᦠࡋࡓ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺㄪᰝ㸦Tokyo Teen Cohortᕷࡢ⏕ά⪅ࡣࠊᚰࡢ೺ᗣࢆ⼃ࡴࡉࡲࡊࡲ࡞せᅉ࡟᫹ࡉࢀࡿࠋᑡ
Study, N=3171㸧ࡣࠊ14ṓ᫬㏣㊧ゼၥㄪᰝ㸦➨3ᅇㄪᰝ㸧ࢆணᐃ㏻ࡾ᏶Ꮚ㧗㱋໬ࡀ㐍ࡴᮾி࡟࠾࠸࡚ࠊᏊ࡝ࡶ࣭ⱝ⪅ࡢ࣓ࣥࢱࣝ࣊ࣝࢫ
஢ࡋࡓ㸦㏣㊧⋡85㸣㸧ࠋ⌧ᅾࠊ16ṓ᫬㏣㊧ゼၥㄪᰝ㸦➨4ᅇㄪᰝ㸧ࡀࡸ⮬ẅࠊㄆ▱⑕ࢆࡣࡌࡵ࡜ࡍࡿᚰࡢ೺ᗣၥ㢟ࡣࠊ㒔Ẹࡢࡃࡽࡋᙜึィ⏬࡟ࡑࡗ࡚㡰ㄪ࡟㐍⾜୰࡛࠶ࡾ⣙༙ศࢆ᏶஢ࠋࡲࡓࠊTokyo࡜೺ᗣ࡟㛵ࢃࡿႚ⥭ࡢၥ㢟࡛࠶ࡿࠋ༊࣭ᕷ࡜㐃ᦠࡋࡓ኱つᶍฟ
Teen Cohort ࡢ⣙1/10ࡢཧຍ⪅ࢆᑐ㇟࡟ᐇ᪋ࡋ࡚࠸ࡿ᮶ᡤᆺࢧࣈࢧࣥ
⏕ࢥ࣮࣍ࢺ◊✲࡟ࡼࡿᏊ࡝ࡶ࣭ⱝ⪅ࡢ⢭⚄ⓗ೺ᗣࡸ࢙࣭࢘ࣝࣅ
ࣉࣝㄪᰝࡶࠊ➨2ᅇࡢ⦪᩿ㄪᰝࢆ↓஦᏶஢ࡋࡓࠋ௒ᖺᗘࡣࠊࡇࢀࡲ࡛
࣮࢖ࣥࢢ࡟㛵ࡍࡿᐇドⓗᡂᯝࡸ⮫ᗋ࣭ࢣ࢔⌧ሙ࡜ࡢ༠ാ࡟ࡼࡿ
࡟ᚓࡽࢀࡓࣂ࢖᳨࢜యࡢゎᯒࢆ㐍ࡵࠊ≉࡟௦⾲ⓗ࡞⤊ᮎ⢾໬⏘≀࡛ㄆ▱⑕࣭⢭⚄㞀ᐖࡢᆅᇦࢣ࢔ࣉࣟࢢ࣒ࣛ㛤Ⓨ➼ࠊ♫఍་Ꮫⓗ᪉࠶ࡿ࣌ࣥࢺࢩࢪࣥࡢᛮ᫓ᮇኚື࡜࣓ࣥࢱࣝ࣊ࣝࢫ࡜ࡢ㛵㐃ࢆ᳨ドࡋἲ࡟ࡼࡿᚰࡢ೺ᗣ࡙ࡃࡾ◊✲ࡢ♫఍㑏ඖࡀồࡵࡽࢀ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ 

－ 23 －

(3) ᅜ ෆእࡢ◊✲≧ἣ㸸ࣉࣟࢪ࢙ࢡࢺ࡛ࡣ⤫ྜኻㄪ⑕ࡢ␗✀ᛶᅇ㑊࡜ᐈほⓗデ᩿࡟᭷⏝࡞ࣂ࢖࣐࣮࣮࢜࢝ࢆྠᐃࡍࡿ࡜ྠ᫬࡟ࢺࣛ
ࣥࢫ࣮ࣞࢩࣙࢼࣝࣜࢧ࣮ࢳ㸦἞㦂㸧ࢆ㐙⾜ࡋࠊᅜෆእࡢ➨୍⥺ࡢ◊✲⪅ࢆᣍ⮴ࡋ࡚ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࢆ୺ദࡍࡿ࡞࡝ࠊಶయࠊ⣽⬊࡛ࣞ࣋ࣝࡢከ㠃ⓗ࢔ࣉ࣮ࣟࢳ࠿ࡽࠊ⢾໬ࢫࢺࣞࢫࢆ㍈࡟ࠊ⢭⚄⑌ᝈⓎ⑕ࡢศᏊᶵᗎ࡟㏕ࡿ◊✲ࢆ⥅⥆ࡋ࡚࠸ࡿࠋ

(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⤫ྜኻㄪ⑕ࡢண㜵࣭デ᩿࣭἞⒪࡟᭷⏝࡞᪂ࡓ࡞ࣂ࢖࣐࣮࣮࢜࢝ࢆ᫂ࡽ࠿
࡟ࡋࠊࡑࡢศᏊᇶ┙ࡢ✲᫂࡜᪂ࡓ࡞ඛไ་⒪ᡓ␎ࢆ☜❧ࡍࡿࠋ㒔❧⑓㝔࡜ࡶ㐃ᦠࡋࡓࡼࡾ᭷ຠ࡞἞⒪ἲ࣭ண㜵ἲࢆ๰ฟࠊ♫఍㑏ඖࢆᅗࡿࠋձ἞
㦂⑕౛࣭ዌຌ⑕౛࣭ᕼᑡ㑇ఏᏊኚ␗ࢆ᭷ࡍࡿ⑕౛➼ࡢ࣓ࢱ࣮࣒࣭࣎ࣟࢤ
ࣀ࣒ゎᯒ㸸⢾໬ࢫࢺࣞࢫ㛵㐃ศᏊࡢᐃ㔞࡟ᇶ࡙ࡁ⑌ᝈࢥ࣮࣍ࢺࢆ㝵ᒙ໬ࡍࡿࠋ㝵ᒙ໬ࡉࢀࡓྛ⩌࡟࠾࠸࡚ࠊ௦ㅰ⏘≀ࡸࢤࣀ࣒࡞࡝ࡢ⏕≀Ꮫⓗ࡞᝟ሗ࡜ࠊ⢭⚄⑕≧ࠊ㌟య⑕≧࡞࡝ᵝࠎ࡞⮫ᗋ᝟ሗࢆẚ㍑᳨ウࡋࠊணᚋண
ࠊ἞⒪཯ᛂᛶࠊ෌Ⓨ㜵Ṇࠊ㌟యྜే⑕ࡢண㜵࡟ᐤ୚ࡍࡿせᅉࢆ᫂ࡽ࠿
࡟ࡍࡿࠋղiPS⣽⬊࠿ࡽศ໬ㄏᑟࡋࡓ࢔ࢫࢺࣟࢧ࢖ࢺࣔࢹࣝ࡟ࡼࡿ᪂ࡓ
࡞ᢠ⢾໬࣭⬺⢾໬≀㉁ࢆྠᐃ㸸✺㉳ఙ㛗࡞࡝ࡢᙧែኚ໬ࠊ௦ㅰ⏘≀ࡢศᯒࢆ⾜࠸ࠊ㑇ఏ࡜⎔ቃせᅉࡀ⢾໬ᣦᶆࢆ௓ࡋࠊ࡝ࡢࡼ࠺࡟⣽⬊ᶵ⬟ࡢኚᐜࢆច㉳ࡋ࡚࠸ࡿࡢ࠿ࡑࡢศᏊᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋճ๗᳨⬻࣭⬻⏬ീࢆᇶ┙࡟ࡋࡓ⢾໬ࢫࢺࣞࢫࡢ⬻ෆࢿࢵࢺ࣮࣡ࢡࡢゎ᫂㸸ᢠ⢾໬ᢠయ࡟ࡼ
ࡿ⵳✚⬻㡿ᇦࡢྠᐃࠊHPLC࡟ࡼࡿ⬻ෆ⵳✚ᐃ㔞࡟ຍ࠼ࠊ⬻ᶵ⬟⤖ྜᛶࢹ࣮ࢱࢆ⵳✚ࡋࠊ௦ㅰ⏘≀ࢹ࣮ࢱ➼ࠎ࡜㐃⤖ࠊࡑࡢ㛵㐃࡜ᅉᯝࢆศᯒࡍ
ࡿࠋմ᪂ࡓ࡞⢾໬⵳ ✚ࣔࢹ ࣝື≀ࡢసฟ࡜ࡑࡢ ⾜ື⸆ ⌮Ꮫⓗゎᯒ㸸
Glo1KO࣐࢘ࢫࡢ⾜ືኚ໬ࢆ࣮࣋ࢫ࡟ࠊ⎔ቃᅉ࡜ࡋ࡚ࡢᚰ⌮♫఍ⓗࢫࢺࣞࢫ࡟ᛂࡌࡓ⾜ືኚᐜࡢ㐪࠸࡟╔┠ࡍࡿࡇ࡜࡛ࠊ⤫ྜኻㄪ⑕ࡢⓎ⑕⮫⏺
ᮇࡢ⾜ືኚ໬࡜⏕యෆࠊ⬻ෆࡢ⢾໬⵳✚ࡢ⤒᫬ⓗኚ໬ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

㸦1㸧㸧ᡂᯝࡢᴫせ⮫ᗋ་Ꮫⓗゎᯒ࡟ࡼࡾࠊ⢾໬࣐࣮࣮࢝ࡢஹ㐍ࡀ⑌ᝈࡢ㔜⠜ᗘࢆ཯ᫎࡋࠊ
≉࡟ゝㄒ⬟ຊࡸどぬ᝟ሗฎ⌮࡜࠸ࡗࡓㄆ▱ᶵ⬟࡜㛵㐃ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ᪂ࡓ࡟ணᚋண ࡟᭷⏝࡞⢾໬࣐࣮࣮࢝ࢆぢฟࡋࠊ㛵㐃ࡍࡿࢤࣀ࣒ࡢ
Ḟኻ࣭㔜」ࢆྠᐃࡋࡓࠋ⢾໬ࢫࢺࣞࢫࡀஹ㐍ࡋࡓᝈ⪅ࡢ๗᳨⬻ࢆ⏝࠸ࡓ◊✲࠿ࡽࡣ㢧ⴭ࡞⚄⤒✺㉳᭤⋡ࡢቑ኱ࢆぢฟࡋࡓࠋ㠀౵くⓗ࠿ࡘ⡆౽࡞⢾໬ࢫࢺࣞࢫ ᐃࢶ࣮ࣝ࡟ࡼࡗ࡚⑌ᝈ࡜⢾໬ࢫࢺࣞࢫ࡜ࡢ㛵㐃ᛶࢆ෌☜ㄆࡋࠊᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲࡬㐺ᛂᣑ኱ࢆᅗࡿࡇ࡜࡛ࠊ⢾໬ࢫࢺࣞࢫࡀ⑌
ᝈࡢⓎ⑕࡟㛵ࢃࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ἞⒪ᡓ␎࡜ࡋ࡚ࠊࣆࣜࢻ࢟ࢧ࣑ࣥ
ࢆ⏝࠸ࡓ἞㦂ࢆ᥎㐍ࡋࠊ᪂つ἞⒪⸆࡜ࡋ࡚ࡢᢎㄆࡀᐇ⌧ࡋࡘࡘ࠶ࡿࠋ࣐
࢘ࢫࣔࢹࣝࢆ⏝࠸ࡓゎᯒ࡟ࡼࡾࠊGlo1 KO࡜VB6Ḟஈࡢ⤌ࡳྜࢃࡏ࡟ࡼ
ࡿ๓㢌⓶㉁≉␗ⓗ࡞࣑ࢺࢥࣥࢻࣜ࢔ᶵ⬟㞀ᐖࢆ᫂ࡽ࠿࡟ࡋࡓࠋᝈ⪅⏤᮶
ࡢiPS⣽⬊ࢆ☜❧ࡋࠊࢢࣜ࢔⣽⬊ࡢ✺㉳ඛ➃㒊࡟⤊ᮎ⢾໬⏘≀ࡀ⵳✚ࡋ࡚࠸ࡿࡇ࡜ࡸ࢔ࢫࢺࣟࢧ࢖ࢺᶵ⬟࡟␗ᖖࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓࠋ(1) ᴫ せ㸸⤫ྜኻㄪ⑕ࡢศᏊᇶ┙࡟ࡘ࠸࡚ࠕ⢾໬㸦࢝ࣝ࣎ࢽࣝ
ࢫࢺࣞࢫࠖࡢไᚚࢆ㍈࡟ࠊ⏕⌮᳨యࠊ⣽⬊ࣔࢹࣝࠊື≀ࣔࢹࣝࠊ๗
᳨⬻ࢆά⏝ࡋࡓከ㠃ⓗ࢔ࣉ࣮ࣟࢳ࡟ࡼࡾ᫂ࡽ࠿࡟ࡍࡿࠋ≉࡟ࠊձࣆࣜࢻ࢟ࢧ࣑ࣥ࡟ࡼࡿ἞㦂ࢆ᥎㐍ࡋࠊ᪂つ἞⒪⸆࡜ࡋ࡚♫఍㑏ඖࢆᐇ⌧ࡍࡿ࡜ඹ࡟ࠊࡑࡢ⸆⌮స⏝ࢆಶయ࡛ࣞ࣋ࣝゎ᫂ࡍࡿࠋղዌຌ⑕౛
࣭ᕼᑡ㑇ఏᏊኚ␗ࢆ᭷ࡍࡿ⑕౛➼ࡢ௦ㅰ⏘≀࣭ࢤࣀ࣒᝟ሗࢆ㋃ࡲ
࠼ࠊ⮫ᗋ᝟ሗࢆ⢭ᰝࡋࠊ⑌ᝈࡢணᚋண ࡸ἞⒪཯ᛂᛶ➼࡟ᐤ୚ࡍࡿ
ᅉᏊࢆ᫂ࡽ࠿࡟ࡍࡿࠋճiPS⣽⬊࠿ࡽศ໬ㄏᑟࡋࡓ࢔ࢫࢺࣟࢧ࢖ࢺ
ࣔࢹࣝ➼ࡢホ౯⣔ࢆά⏝ࡍࡿࡇ࡜࡛᪂ࡓ࡞ᢠ⢾໬≀㉁➼ࢆྠᐃࡍࡿࠋմ๗᳨⬻࡛ࡢ▱ぢࢆᇶ┙࡟ࠊ⢾໬ࢫࢺࣞࢫࡢ⬻ෆ⑓ែࢿࢵࢺ࣡
࣮ࢡࢆゎ᫂ࡍࡿࠋյ⢾໬⬤ᙅᛶࡢ⣲ᅉ࡟ຍ࠼ࠊᚰ⌮♫఍ⓗࢫࢺࣞࢫࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊᐇ⮫ᗋ࡟༶ࡋࡓࣔࢹࣝື≀ࡢసฟ࡜⾜ື⸆⌮Ꮫⓗゎᯒࠊ᪂ࡓ࡞἞⒪௬ㄝࡢ๰ฟࢆ┠ᣦࡍࠋ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼: Berto S et al., Proc Natl Acad Sci
USA (2019); Mendizabal I et al., Genome Biol (2019); Mizutani et al.,Transl Psychiatry (2019); Yamasaki S et al., Schizophr Res (2019); Itokawa
M et al., Psychiatry Clin Neurosci. (2019); Toriumi K et al., IMARSHIGHLIGHTS (2019); Saiga R et al., Microsc. Microanal. (2019); Arai M
et al., 21st TMIMS International Symposium (2019); Itokawa M et al., 6th
ASCNP (2019); Horiuchi et al., AsCNP Congress (2019); Itokawa M et al.,
6th ASCNP (2019) ௚ ࠊ ᅜ 㝿 Ꮫ ఍ 10 ௳ 㸦 21st TMIMS International
Symposium, 6th Congress of ASCNP, 21st TMIMS International
Symposium㸧ࠊᅜෆᏛ఍17௳㸦➨29ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ࠊ➨41ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍ࠊ᪥ᮏࢹ࢖ࢣ࢔Ꮫ఍ࠊ᪂Ꮫ⾡㡿ᇦ◊✲ࠊ➨
115ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍ࠊ➨66ᅇᛂ⏝≀⌮Ꮫ఍᫓ᏘᏛ⾡ㅮ
₇఍ࠊ➨14ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ࠊ➨43ᅇ᪥ᮏ㑇ఏ࢝࢘ࣥࢭࣜࣥࢢ
Ꮫ఍࣭➨26ᅇ᪥ᮏ㑇ఏᏊデ⒪Ꮫ఍㸧ࠊᬑཬάື࣭ㅮ₇఍➼52௳㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ㸦㠀ᖖ໅⫋ဨ㸧
ྜྷᕝⲁ
㕥ᮌ୍ᾈ
ᑠᖭ⳯ࠎᏊ
㔝ཎἨ
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஭ୖᬛᏊ

(2) ◊✲⪅ྡ㸦ᖖ໅⫋ဨ㸧
⣒ᕝᫀᡂ
ᇼෆὈỤ
ᐑୗගᘯ
㫽ᾏ࿴ஓ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸᪂஭ ㄔ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ

－ 24 －◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ᡂᯝࡢᴫせ➨㸱ᮇࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ♫఍ᩋ໭ࢫࢺࣞࢫࢆ⏝࠸ࡓ᪂つ㞴἞ᛶ࠺ࡘ⑓ࣔࢹࣝࢆ㛤Ⓨࡋࡓࠋࡇࡢࣔࢹ࡛ࣝࡣ࠺ࡘ⑓ᵝࡢᅇ㑊⾜ືࡀ࡯ࡰ࡛ฟ⌧ࡍࡿࠋࡲࡓ((*㸦⬻Ἴ㸧࡟ࡼࡗ࡚ࠊ࠺ࡘ⑓ᵝ୙╀≧ែࡀฟ⌧ࠊᢠ࠺ࡘ⸆࡛ᨵၿࡍࡿࡇ࡜ࢆ☜ㄆࡋࡓࠋࡍ࡞ࢃࡕୡ⏺࡛ึࡵ࡚ࡢ╧╀㞀ᐖࢆక࠺࠺ࡘ⑓ࣔࢹࣝ࡜ᡂࡾᚓࡿࠋࡇࡢࣔࢹࣝࢆ⏝࠸࡚ࠊࡉࡲࡊ
ࡲ࡞ᢠ⅖⑕≀㉁࡟࠺ࡘ≧ែᨵၿຠᯝ࣭╧╀ᨵၿຠᯝࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓࠋ⏘Ꮫ㐃ᦠ◊✲࡛᪂ࡓ࡞ᢠ࠺ࡘ≀㉁ࢆ」ᩘⓎぢࡋࠊ⌧ᅾ≀㉁≉チ⏦ㄳ୰ࡲࡓࡣ‽ഛ୰࡛࠶ࡿࠋࡉࡽ࡟ࠊࣔࢹࣝ࠿ࡽ((*␗ᖖ㸦≉࡟ᾏ㤿ȟࣃ࣮࣡㸧ࠊ⾑ᾮࣂ࢖࣐࣮࣮࢜࢝ࠊ⣅౽୰≀㉁࡞࡝ࠊᐈほⓗデ᩿ἲࡢࢩ࣮ࢬࢆぢฟࡋࡓࠋ௒ᚋࡣࣄࢺ࡬ࡢᛂ⏝ࢆ┠ᣦࡍࠋᡂ య ⬻ ⏤ ᮶ D23& ᇵ 㣴 ἲ ࡢ ☜ ❧ ࡞ ࡝ ࢆ ⾜ ࠸ ࠊ ᪂ つ D23& ࣐ ࣮ ࢝ ࣮
SOH[LQ%ࢆⓎぢࡋࠊ௒ࡲ࡛ㅦࡀከ࠿ࡗࡓD23&ࡢ⬻ෆືែࡢ᪂ࡓ࡞ഃ㠃ࢆ᫂ࡽ࠿࡟ࡋࡘࡘ࠶ࡿࠋࡶ࡜ࡶ࡜D23&ࡣᡂேᮇࡢࢢࣜ࢔⣽⬊ࡢ୰࡛ࠊ᭱ࡶᩘࡀከ࠸୍᪉ࠊࡑࡢᶵ⬟ゎ᫂ࡣ㐜ࢀ࡚࠸ࡿࠋ㦫࠸ࡓࡇ࡜࡟ୖ㏙ࡢ᪂つD23&࣐࣮࣮࢝࡜$'ࡢ୺せ⑓ኚ࡛࠶ࡿ࢔࣑ࣟ࢖ࢻ⵳✚࡟㛵㐃ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸦≉㢪῭㸧㸦ㄽᩥࣜࣂ࢖ࢫ㸧ࠋྠⓎぢࡣᚑ᮶ࡢ࢔࣑
ࣟ࢖ࢻ௬ㄝࡢぢ┤ࡋࡢᚲせᛶࢆ♧၀ࡋ࡚࠾ࡾࠊ᪂ࡓ࡞ほⅬ࠿ࡽࡢ᰿ᮏ
ⓗ἞⒪⸆㛤Ⓨ࡟ࡘ࡞ࡀࡿࠋࡲࡓࠊD23&ࡢ᪂ࡓ࡞ᶵ⬟ゎᯒ࡛ࡶࠊࢢࣜࢩ
ࣥࡢศἪ⣽⬊ࡢྍ⬟ᛶ࡞࡝ࠊࡉࡲࡊࡲ࡞᪂▱ぢࡀฟ࡚࠸ࡿࠋ⎔ቃᅉᏊࡢᅜ㝿ඹྠ◊✲࡛ࡣኴ㝧ග࡜཮ᴟᛶ㞀ᐖࡢⓎ⑕࡟㛵㐃ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࠊඹྠⴭ⪅࡜ࡋ࡚ㄽᩥࢆ᪂ࡓ࡟ᩘሗⓎ⾲ࡋࡓࠋࡉࡽ࡟࢖ࣥࢱ࣮ࢿ
ࢵࢺ౑⏝࡟㛵ࡍࡿᅜ㝿࢔ࣥࢣ࣮ࢺㄪᰝ࡟ࡶᘬࡁ⥆ࡁཧຍ୰࡛࠶ࡿࠋ◊        ✲       ᡂ       ᯝ   ◊✲ᮇ㛫ᖺ᭶䡚ᖺ᭶
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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᴙᯘ⩏Ꮥ㸧㉸ᑡᏊ㧗㱋໬ࡢ㐍⾜࡛ࠊ࠺ࡘ⑓࡞࡝ࢫࢺࣞࢫᛶ⢭⚄⑌ᝈ◊   ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼➨㸲ᮇࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࠺ࡘ⑓ࣔࢹࣝື≀◊✲࡜D23&࡜$'ࡢ㛵✲ࡸ$'࡜ࡢ㛵㐃◊✲ࡣࡲࡍࡲࡍ㔜せ࡜࡞ࡗ࡚࠸ࡿࠋᡃࠎࡢ࠺
㐃◊✲ࢆᘬࡁ⥆ࡁ⾜࠺ࠋࣔࢹࣝື≀࠿ࡽぢฟࡉࢀࡓ⾑୰࣭౽୰ࣂ࢖࢜
ࡘ⑓ࣔࢹࣝࡣࠊ╧╀㞀ᐖࢆక࠺ୡ⏺ึࡢࣔࢹࣝ࡜࡞ࡗ࡚࠾ࡾ
࣐࣮࣮࢝ೃ⿵ࡣࣄࢺࢧࣥࣉࣝࢆ⏝࠸᳨࡚ドࡍࡿࠋࡉࡽ࡟௒ᚋࡣࠊᢠ⅖㧗࠸➇தຊࢆᣢࡘ࡜ᛮࢃࢀࡿࠋࡉࡽ࡟ࢥࣟࢼࡢ᫬௦࡟ධࡾࠊ
⑕⸆࡟ࡼࡿ⮫ᗋ἞㦂ࢆィ⏬ࡋࠊ࠺ࡘ⑓ண㜵ࡑࡋ࡚ㄆ▱⑕ண㜵࡜࠸࠺᪂ࢫࢺࣞࢫ࡜ࡢୖᡭ࠸௜ࡁྜ࠸᪉ࡀࡼࡾồࡵࡽࢀࡿࡼ࠺࡟࡞ࡗ ࡋ࠸ᴫᛕࢆษࡾ㛤ࡁࡓ࠸ࠋ୍᪉ࠊᇶ♏◊✲࡛ࡣࠊ᪂ࡓ࡞D23&ࡢᙺ๭ࢆࡓࠋ௒ᚋࡢ⤒῭≧ἣ࡟ࡼࡗ࡚ࡣ⮬ẅ⪅ࡢቑຍࡶ༴᝹ࡉࢀ࡚࠸ ᫂ࡽ࠿࡟ࡍࡿࠋࡉࡽ࡟ᇵ㣴D23&ࢆ⏝࠸ࡓࢫࢡ࣮ࣜࢽࣥࢢ⣔ࢆ⏝࠸࡚᪂ࡿࠋᡃࠎࡢⓎぢࡋࡓ᪂つᢠ࠺ࡘ≀㉁ࡢ᪩࠸ᐇ⏝໬ࡀồࡵࡽࢀ つ$'᰿ᮏⓗ἞⒪⸆ࡢ㛤Ⓨ◊✲ࢆࠊ⏘Ꮫ㐃ᦠ◊✲ࢆ㏻ࡌ࡚⾜࠺ࠋࡉࡲࡊ
ࡿࠋ୍᪉ࠊ$'ࡢ᰿἞⸆㛤Ⓨࡣ㡻᣸ࡋ࡚࠾ࡾࠊ௒ᚋࡣㄆ▱⑕ᨻ ࡲ࡞⎔ቃᅉᏊ࡜Ẽศ㞀ᐖⓎ⑕࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ⟇ࡢぢ┤ࡋࡀᚲせ࡛࠶ࢁ࠺ࠋ  ᅜෆእࡢ◊✲≧ἣ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
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ィ⏬ࢆᐇ᪋ࡋ࡚࠸ࡿࠋලయⓗ࡟ࡣࠊ㸯㸧Ṛᚋ⬻◊✲ࠊ㸰㸧ࣔࢹࣝື≀㛤Ⓨࠊ㸱㸧⎔ቃᅉᏊ◊✲ࠊ㸲㸧࢜ࣜࢦࢹࣥࢻࣟࢧ࢖
ࢺ๓㥑⣽⬊ ௨ୗD23&V࡜⥲⛠ࡍࡿ ࡢᇶ♏◊✲࡜ࢫࢡ࣮ࣜࢽ
ࣥࢢ⣔ࡢ㛤Ⓨࠊ㸳㸧᪂つࣂ࢖࣐࣮࣮࢜࢝ࠊ἞⒪ἲࡢ⮫ᗋ἞㦂➼ࢆ⾜ࡗ࡚࠸ࡿࠋ  ᴫせ୺࡞◊✲ᡂᯝ 

－ 25 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ(3) ᅜෆእࡢ◊✲≧ἣࢼࣝࢥࣞࣉࢩ࣮◊✲ࡣከᩘ⾜ࢃࢀ࡚࠸ࡿࡀࠊ⏕๓ྠព࡟ᇶ࡙ࡃࢼࣝ
ࢥࣞࣉࢩ࣮Ṛᚋ⬻⤌⧊ࢆಖ᭷ࡍࡿᶵ㛵ࡣୡ⏺࡛ࡶ⛥࡛࠶ࡿࠋṚᚋ⬻ࢆ⏝࠸ࡓ⎔ቃᅉᏊࡢゎᯒ࡜ࡋ࡚DNA࣓ࢳࣝ໬◊✲ࢆ⾜࠺ࡇ࡜ࡶࠊୡ
⏺࡟ඛ㥑ࡅࡓヨࡳ࡛࠶ࡿࠋ╧╀ぬ㓰ࡢ⚄⤒ᶵᵓࡣゎ᫂ࡀࡍࡍࢇ࡛࠸ࡿࡀ⚄⤒άືࢆᨭ࠼ࡿ௦ㅰ
ኚື࡜╧╀ぬ㓰ࡢ≧ែኚ໬ࡢ᫬㛫ⓗ㛵㐃ࡣ᪉ἲㄽⓗ࡞ไ㝈࠿ࡽ࡯࡜ࢇ࡝࡞ࡉࢀ࡚ࡇ࡞࠿ࡗࡓࠋ⣽⬊ෆATP⃰ᗘࡢin vivoࣜ࢔ࣝࢱ࢖࣒ィἲࡢ㛤Ⓨࡣࠊ╧╀ぬ㓰ไᚚࡢ᪂ࡓ࡞ഃ㠃ࢆゎ᫂ࡍࡿᡭẁ࡜࡞ࡿࠋ㐣╀⑕ࡢ⮫ᗋᡤぢ᳨࣭య࡛ࡢ◊✲࡜ࣔࢹࣝື≀࡛ࡢ◊✲ࢆ୪⾜ࡋࠊ⮫ᗋ⑕≧࡜ᇶ┙◊✲ࢆ᭷ᶵⓗ࡟⤖ࡧ௜ࡅࡓ◊✲ࡀᡃࠎࡢ≉ᚩ࡛࠶ࡿࠋ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
࣭Shimada M, Miyagawa T, ---,Honda M. Epigenome-wide association
study of narcolepsy-affected lateral hypothalamic brain and overlapping
DNA methylation profiles between narcolepsy and multiple sclerosis. doi:
10.1093/sleep/zsz198. Sleep.
࣭Miyagawa T, --,Honda M. A missense variant in PER2 is associatedwith delayed sleep-wake phase disorder in a Japanese population. doi:
10.1038/s10038-019-0665-6. J Hum Genetics, 64(12):1219-1225
࣭Honda M, Ito W. MSLT and 24hr PSG for diagnosing idiopathic
hypersomnia. Sleep 2019 San Antonio, USA [2019/6/9]
࣭ኟᇼ᫭ୡ. In vivo optical recording reveal state-dependent intracellular
ATP dynamics in neurons. Neuro2019ࠊ᪂₲ [2019/7/27](1) ᴫせ⌧௦♫఍࡛ࡣ⏕ά⩦័ࡸປാࡢ㉁ⓗኚ໬࠿ࡽ╧╀㞀ᐖࡀቑຍࠊᅜ
Ẹࡢ14.9%ࡀ៏ᛶⓗ╀Ẽࢆッ࠼ࠊຠ⋡పୗࡸ஦ᨾ࡟ࡘ࡞ࡀࡿㄆ▱ᶵ⬟㞀ᐖࢆࡁࡓࡍࠋࡲࡓ୰㏵ぬ㓰ᆺ୙╀ࡣຍ㱋ࡸ⑌ᝈ࡛ቑຍࡍࡿࡀࡑ
ࡢᇶ┙ࡣᮍゎ࡛᫂≉␗ⓗ἞⒪⸆ࡣᏑᅾࡋ࡞࠸ࠋᮏ◊✲࡛ࡣ᪥ᮏே࡟
ከ࠸㐣╀⑕࡛ࡢ╧╀ぬ㓰ไᚚ࡟ࡘ࠸࡚⑌ᝈ㛵㐃㑇ఏᏊࡢᶵ⬟᳨ウ࠿
ࡽ㏕ࡿ࡜࡜ࡶ࡟ࠊከᩘ⑕౛࡛୰㏵ぬ㓰ࡢbiomarker᥈⣴ࢆࡍࡍࡵ୰㏵
ぬ㓰ᆺ୙╀ࡢ⑓ែ⌮ゎࢆ⾜࠺ࡇ࡜ࠊࡑࡋ࡚ᇶ┙࡜࡞ࡿ╧╀ぬ㓰࡜⚄⤒⣽⬊ෆ࢚ࢿࣝࢠ࣮௦ㅰࡢ㛵㐃ࢆゎ᫂ࡋࠊデ᩿἞⒪࡜╧╀ᨵၿἲ࡜ࡋ࡚ࡢ㑏ඖࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ 㐣╀⑕ࡢ⏕≀ᣦᶆࡢ᥈⣴ྠᐃ

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ձ

⬻⬨㧊ᾮࡢ࣓ࢱ࣮࣒࣎ࣟゎᯒ࡟ࡼࡾࠊ㐣╀⑕≉␗ⓗ࡞⬻ෆ௦ㅰࣉࣟࣇ
࢓࢖ࣝࢆྠᐃࠊ⑓ែゎ᫂࡜⑌ᝈᣦᶆ㛤Ⓨ࡟ࡘ࡞ࡄࠋ≉Ⓨᛶ㐣╀⑕ࡢឤཷᛶ㑇ఏᏊࢆྠᐃࠊ␗✀ᛶࡢ㧗࠸≉Ⓨᛶ㐣╀⑕ࡢࢧࣈࢢ࣮ࣝࣉࢆྠᐃ
ࡋࠊPrecision medicine࡟㈉⊩ࡍࡿࠋ
PSG᫬⣔ิゎᯒ➼ࢆ⏝࠸࡚୺ほⓗ╧╀ឤࡢᐈほホ౯ࣔࢹࣝࢆసᡂࠊከ
ඖⓗ࡞╧╀ࡢ㉁ࡢᴫᛕࢆᩚ⌮ࡋࠊⰋ㉁࡞╧╀ࡢᐃ㔞ホ౯ࢆ⾜࠺ࠋ⸆⌮Ꮫⓗᡭἲࡸ㑇ఏᏊᨵኚື≀ࢆ⏝࠸࡚ࠊ⏕⌮ⓗ࡞╧╀ぬ㓰ไᚚࡢ௦ㅰᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ௦ㅰࡢኚືࡀ╧╀ぬ㓰ไᚚ࡬ࡢᙳ㡪࡜ࠊぬ㓰⚄⤒⣔ࡢ᧯సࡀࡶࡓࡽࡍ௦ㅰኚືࡢ᳨ウࢆ㏻ࡌ࡚ࠊ௦ㅰࡢどⅬ࠿ࡽ㐺ษ࡞╧╀ぬ㓰ไᚚ(Ⰻ㉁࡞╧╀)ࡢ᮲௳ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ղ 㐣╀⑕ᝈ⪅ࡢ⑕≧࣭デ᩿ࡢᐈほⓗᣦᶆࡢ㛤Ⓨ࣭ ⌧⾜ࡢ╧╀㞀ᐖᅜ㝿ศ㢮࡛ࡣࠊ⑓ⓗ㐣╀ࡣࠕ୙㐺ษ࡞᫬㛫࡟ᒃ╀ࡾࢆ཯᚟ࠖࠕ╧╀᫬㛫ࡢᘏ㛗ࠖࡢ2ࡘ࡛ᐃ⩏ࡉࢀࠊࡑࢀࡒࢀ཯᚟╧╀₯᫬᳨ᰝ(MSLT)࡛ࡢධ╀ഴྥ(ᖹᆒ╧╀₯᫬8ศ௨ୗ)࡜୍᪥ࡢ⥲╧╀᫬㛫ᘏ㛗(660
ศ௨ୖ)ࢆ㜈್࡜ࡋ࡚デ᩿ࡉࢀࡿࠋ╧╀እ᮶࡟࡚≉Ⓨᛶ㐣╀⑕ࢆ␲ࢃࢀࠊ
デ᩿┠ⓗ࡛㏻ᖖࡢPSG-MSLT ࡟ຍ࠼࡚24᫬㛫PSGࢆ⾜ࡗࡓ35౛ࢆᑐ㇟࡜ࡋ࡚MSLT࡜24hrPSGࡢឤᗘṇ☜ᗘࢆ᳨ウࡋࡓࠋ᭱⤊ⓗ࡞≉Ⓨᛶ㐣╀⑕ࡢデ᩿࡟ᑐࡋ࡚ࠊMSLTࡣឤᗘ12%ṇ☜ᗘ34㸣ࠊ24᫬㛫PSGࡣ92%࣭83㸣࡛࠶ࡾࠊ≉Ⓨᛶ㐣╀⑕ࡢホ౯ࡣ24hrPSG࡛⾜࠺࡭ࡁࡇ࡜ࢆᥦၐࡋࡓࠋճ ࢚ࢿࣝࢠ࣮௦ㅰ࠿ࡽࡳࡓ╧╀ぬ㓰ไᚚࡢᇶ┙◊✲࣭ ⚄⤒⣽⬊ෆATP⃰ᗘࡢኚື࡜⬻⾑ὶ≧ែ(࢚ࢿࣝࢠ࣮౪⤥)࠾ࡼࡧ⚄⤒άື(࢚ࢿࣝࢠ࣮ᾘ㈝)ࡢ᫬㛫ⓗ㛵ಀ࡟ࡘࡁ᳨ウࢆ㐍ࡵࡓࠋATP⃰ᗘࡣ࣒ࣞ╧╀≉␗ⓗ࡟ῶᑡࠊぬ㓰ᗘୖ᪼࡟కࡗ࡚ୖ᪼ࡍࡿࡇ࡜ࠊ╧╀ぬ㓰࡟క࠺ATPኚືࡣ኱⬻⓶㉁඲య࡛ྠᮇࡋ࡚⏕ࡌࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡲࡓNREM╧╀ẁ㝵࡛ࡣmicroarousal࡟క࠺ATP⃰ᗘୖ᪼ࡀ࠶ࡿࡀ㏿ࡸ࠿࡟ඖࡢࣞ࣋
ࣝ࡟ᡠࡿᜏᖖᛶ⥔ᣢไᚚ⣔ࡀᏑᅾࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ࣭ どᗋୗ㒊࢜ࣞ࢟ࢩࣥ⚄⤒ࡢኚᛶ⬺ⴠࡀࢼࣝࢥࣞࣉࢩ࣮ࡢ⑓ែᇶ┙࡜ࡉࢀࡿࡀࠊ㑇ఏᏛⓗゎᯒ࡟㝈⏺࠶ࡾࠊᶵᗎࡣᮍゎ࡛᫂࠶ࡿࠋDNA࣓ࢳࣝ໬࡟ࡣ⎔ቃᅉ࡜㑇ఏᅉࡀᙳ㡪ࡍࡿࡓࡵࠊࢼࣝࢥࣞࣉࢩ࣮࡜೺ᖖᑐ㇟౛ࡢṚᚋ⬻どᗋୗ㒊࡟࠾ࡅࡿDNA࣓ࢳࣝ໬≧ែࢆゎᯒࡋࡓࠋᚋ㒊どᗋୗ㒊࡛ࡣ77ࣨᡤࡢDMR(⑌ᝈ㛵㐃࣓ࢳࣝ໬㡿ᇦ)ࡀྠᐃࡉࢀࡓᑐ↷㡿ᇦ(ഃ㢌ⴥ)࡛ࡣ5ࣨᡤ࡟࡜࡝ࡲࡾࠊᚋ㒊どᗋୗ㒊ࡢ⑌ᝈ㛵㐃ᛶࡀ♧၀ࡉࢀࡓࠋDMRࡀᏑᅾࡍࡿ㑇ఏᏊ⩌࡟ࡣ⬡㉁ᛂ
⟅ࡸ௦ㅰ࡟㛵㐃ࡍࡿࣃࢫ࢙࢘࢖ࡀ᭷ព࡟ከࡃࠊᡃࠎࡀᥦၐࡍࡿࢼࣝࢥࣞࣉࢩ
࣮ࡢ⬡⫫㓟௦ㅰ␗ᖖ௬ㄝࡀᨭᣢࡉࢀࡓࠋ

ᡂᯝࡢᴫせ

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ኟᇼ᫭ୡࢩࢽ࢔◊✲ဨ ඣ⋢ ஽
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బ⸨ᬸኵᐇ㦂⿵ຓဨ 㛵 ᗣᏊ
ᮏከⰾᏊᐈဨ◊✲ဨ 
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ᑠᒣ⣧ṇᮌᮧᫀ⏤⨾す㔝⢭἞(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚202ᖺ3᭶
㸦5ᖺ㛫㸧

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  㛫࣭  ◊✲  ⪅ྡ  ➼╧╀ぬ㓰ไᚚࡢゎ᫂࡜╧╀㞀ᐖࡢ἞⒪ἲ㛤Ⓨ㸭╧╀ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᮏከ ┿㸧㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 26 －◊       ✲       ᡂ       ᯝ ࣭࠺ࡘ⑓ࡸ⤫ྜኻㄪ⑕ࠊࡲࡓ$'+'ࠊ$6'࡞࡝ࡢⓎ㐩㞀ᐖࡢ⑓ែ࣓࢝
ࢽࢬ࣒ࡢゎ᫂ࡀ㐍ࡳࠊᙜヱᏛၥ㡿ᇦ࡟ᑐࡋ࡚ࠊ᪂つ἞⒪ἲ࠾ࡼࡧண
㜵ἲࡢᥦ᱌ࢆ┠ᣦࡍࠋ⸆≀౫Ꮡ࡟㛵ࡋ࡚ࡣࠊ࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇ᇶᮏἲࠊ⤫   ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ྜᆺࣜࢰ࣮ࢺ㸦,5㸧ᩚഛ᥎㐍ἲࠊࢠࣕࣥࣈࣝ➼౫Ꮡ⑕ᑐ⟇ᇶ ձ ⸆≀౫Ꮡ◊✲ᮏἲࡀ᪋⾜ࡉࢀࡓࡀࠊᅜෆ࡛ࡢ◊✲ࡣ୙༑ศ࡛࠶ࡿࠋᅜእ࡛ ࣭⸆≀౫ᏑࡢศᏊ࣓࢝ࢽࢬ࣒ࡀ᫂ࡽ࠿࡟࡞ࡾࠊ᪂ࡓ࡞἞⒪ἲࡸண㜵ἲࡢᥦ᱌ࡀ࡛ࡁࡿ࡜ᮇᚅࡉࢀࡿࠋ≉࡟ࠊぬࡏ࠸๣౫Ꮡᝈ⪅࡟࠾ࡅࡿ࢖ࡣ኱つᶍ࡞◊✲㈝ࡀᢞࡌࡽࢀ࡚࠸ࡿࡀࠊၥ㢟ゎỴ࡟ࡣ⮳ࡗ࡚ࣇ࢙ࣥࣉࣟࢪࣝࡢ⮫ᗋヨ㦂ࢆ㐍ࡵ࡚࠸ࡿࠋ᪤࡟㛤Ⓨࡋࡓ౫Ꮡ⑕≧ホ࠸࡞࠸ࠋ≉࡟ࠊ୰ᯡ่⃭⸆౫Ꮡ࡟ᑐࡍࡿ἞⒪⸆ࡣ࡞࠸ࠋಶู
౯ᑻᗘࡀᨵⰋࡉࢀࠊฮົᡤ࡞࡝ྛ✀ࡢᶵ㛵࡟࠾࠸࡚᭷ຠ฼⏝ࡉࢀࡿ
໬་⒪ࡢ㔜せᛶࡸᐇ⌧ᛶࡣୡ⏺ⓗ࡟㧗ࡲࡗ࡚࠸ࡿࡀࠊࢸ࣮ࣛ
ࡇ࡜࡛ࠊ⸆≀౫Ꮡၥ㢟ࡢ㍍ῶࡸ἞Ᏻࡢᨵၿ࡟⧅ࡀࡿ࡜ᮇᚅ࡛ࡁࡿࠋ
࣮࣓࢖ࢻ⑊③἞⒪ࡢ◊✲ࡣࠊᙜ◊✲ࢢ࣮ࣝࣉࡀୡ⏺ࢆ≌ᘬࡋղ 㙠③◊✲
࡚࠸ࡿࠋⓎ㐩㞀ᐖ◊✲࡟࠾࠸࡚ࡣࠊື≀ᐇ㦂࡜⮫ᗋ◊✲ࡣࡲ ࣭ࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࡀ㛤ጞࡉࢀࡓࡢ࡛ࠊ௒ᚋࡣࡑࡢᨵⰋࡀᮇᚅ
ࡔ࡯࡜ࢇ࡝⤖ࡧࡘ࠸࡚࠸࡞࠸ࠋὀពḞዴከືᛶ㞀ᐖ $'+' ἞࡛ࡁࡿࠋࡲࡓࠊ⚄⤒㞀ᐖᛶ⑊③Ⓨ⑕⬤ᙅᛶ㛵㐃㑇ఏᏊከᆺࡢྠᐃࢆ⒪⸆ࡣ」ᩘㄆྍࡉࢀ࡚࠸ࡿࡀࠊ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕ $6' ࡢ୰㐍ࡵ࡚࠸ࡿࠋࡉࡽ࡟ࠊ࢜ࣆ࢜࢖ࢻㄏⓎᛶ჎Ẽ჎ྤࡢⓎ⑕⬤ᙅᛶࡸ⦆ᚰ⑕≧ࡢ἞⒪⸆ࡣୡ⏺ⓗ࡟ࡶࡲࡔ࡞ࡃࠊ◊✲㛤Ⓨࡀồࡵࡽࢀ
࿴་⒪࡛ࡢ࢜ࣆ࢜࢖ࢻឤཷᛶ࡜㛵㐃ࡍࡿ㑇ఏᏊࢆぢฟࡍࠋճ 㛵㐃⢭⚄⚄⤒⑌ᝈ◊✲
࡚࠸ࡿࠋ

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㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ◊✲⪅ྡụ⏣࿴㝯ࠊ➟஭ៅஓࠊ⸨⏣㞞௦ࠊす⃝኱㍜ࠊ஭ᡭ⪽୍㑻ࠊ኱ᒸ㟼⾰ࠊᒣᮏ⚽Ꮚࠊྂ⏣ᓥᾈᏊࠊⴗ㔝ὒᏊࠊ᳃ᒇ⏤⣖ࠊᒣす჆ᬕࠊ㟷ᮌㅬ඾ࠊኳ㔝ຌ஧㑻ࠊ᯽஭ὒᩥࠊ኱㇂ಖ࿴ࠊ㛗㇂ᕝ‽Ꮚࠊடࣨ㇂ᝋᏊࠊ୰ᒣிᏊࠊ
Ụ⏿⿱Ꮚࠊᯇᓥ⏤⣖Ꮚࠊ⏣୰⨾ṌࠊṊ⏣ࢡ࣮ࣛࢡࠊ
㧗ᶫ㤶ኸ㔛ࠊᯇ⃝┿ᙬࠊụ❑⤖Ꮚࠊᡂ⏣ᚰࠊ⏣୰┿భ⨾ࠊሯᮏṇኴ㑻ࠊ஭ୖ⌮ᜨࠊᑠᓮⰾᙪࠊ
ⴠྜ㑳⣖Ꮚࠊῧ⏣ⴌࠊ⩏㑣᭷ᙬࠊᇼᏳ⳯ࠊຍ⸨႐ஂࠊᒾୗ ྡྂ ⏤ెࠊᮧᒸΏࠊ
బ⸨ᩔᚿࠊᒾ⏣೺ࠊཎཱྀᙬᏊࠊ
ᑠᯘ኱㍜ࠊᖹ἟ᙬᏊࠊụ⏣᭸ᗈࠊྜྷỈᏕ⥴ࠊ⚄㎶ኴᶞࠊ㣤ᓥ㏻ᙪࠊ
▼ሯᜤ⌮ࠊྜྷ⏣㤶⧊ࠊ୰ᮏⓒྜỤࠊ᳃㔝ⰋⶶࠊᏱ㔝ᜤ௓ࠊᴋ஭ඃ㤶ࠊᐑす ⫕ࠊᶓᕝ┤ேࠊྜྷ⏣ Ⓩࠊ
బ⸨ⱥ᫂ࠊྂ⏣㡴Ꮚࠊᒣᮏ೺୍ࠊ
ෆ㔝ⱱኵࠊᑠᯘᚭࠊྜྷ஭ගಙࠊ
ᒣᮏᩄᩥࠊ᭮Ⰻ୍㑻ࠊᒾᶫ࿴ᙪࠊ
ᯘ⏣┾࿴ࠊᵽཱྀ㐍ࠊ⚟⏣ㅬ୍ࠊጒᑿᰤ୍ࠊᱵ㔝 ඘ࠊ⤖ᇛఙὈᖺ᭶䡚ᖺ᭶
㸦ᖺ㛫㸧  ◊✲ᮇ㛫

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ụ⏣࿴㝯㸧  ᡂᯝࡢᴫせձ ⸆≀౫Ꮡ◊✲࣭࢔ࣝࢥ࣮ࣝ౫Ꮡᝈ⪅࡟࠾࠸࡚ࠊ*,5.ࢳࣕࢿࣝ㜼ᐖ⬟ࢆ᭷ࡍࡿ࢖ࣇ࢙
ࣥࣉࣟࢪࣝࡢ᭷ຠᛶࡀ♧ࡉࢀࡓࠋᗁぬ๣࡛࠶ࡿࢣࢱ࣑ࣥࡣᢠ࠺ࡘస
⏝ࡶᣢࡘࡀࠊࡑࡢᢠ࠺ࡘస⏝ࡢ୍㒊࡟*OX1'ࢧࣈࣘࢽࢵࢺࡀ㛵୚ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ࢜ࣆ࢜࢖ࢻࢩࢫࢸ࣒࡜ࢻ࣮ࣃ࣑ࣥࢩࢫࢸ࣒ࡀ␗
࡞ࡿሗ㓘ࢆᢸ࠺ࡇ࡜ࢆ⬻ෆ⮬ᕫ่⃭ヨ㦂࡟ࡼࡾぢฟࡋࡓࠋ
ղ 㙠③◊✲࣭⑊③ឤཷᛶ࠾ࡼࡧ㙠③⸆ឤཷᛶ࡜㛵㐃ࡍࡿ㑇ఏᏊከᆺࢆከᩘぢฟࡋࡓࠋᵓ⠏ࡋࡓ㙠③⸆㐺㔞ண ᘧࢆ⏝࠸࡚ࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࢆ
⥅⥆ࡋࡓࠋࡲࡓࠊᢠࡀࢇ๣ㄏⓎᮎᲈ⚄⤒㞀ᐖ⬤ᙅᛶ࡜㛵㐃ࡍࡿ㑇ఏ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼Ꮚከᆺࢆྠᐃࡋࡓࠋ
࣭,GH,NHGD%LRO3V\FKLDWU\
ճ Ⓨ㐩㞀ᐖ◊✲
࣭1LVKL]DZDHWDO3KDUPDFRJHQRPLFV
࣭ࣂࣝࣉࣟ㓟ᢞ୚࣐࢘ࢫࡢ$6'ᵝ⾜ືࡀࣛࣃ࣐࢖ࢩ࡛ࣥᨵၿࡍࡿࡇ࡜
࡞࡝ࠊཎⴭㄽᩥ௳ࠊ⥲ㄝ➼௳ࠊ⦅ⴭ௳ࠊᏛ఍Ⓨ⾲࣭ㅮࡸࠊࢭࣟࢺࢽࣥࢺࣛࣥࢫ࣏࣮ࢱ࣮࣊ࢸࣟḞᦆ࣐࢘ࢫࡀ$6'ᵝ⾜ືࢆ
₇➼௳㸦㸫ᖺᗘ㸧♧ࡋࢺࣜࣉࢺࣇ࢓ࣥḞஈ㣗ࡢᦤྲྀ࡛ᨵၿࡍࡿࡇ࡜ࢆぢฟࡋࠊ$6'ࡢ⸆≀⒪ἲࡢ㛤Ⓨ࡟⤖ࡧࡘࡃᡂᯝࢆᚓࡓࠋ  ᅜෆእࡢ◊✲≧ἣ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎࢆゎ᫂ࡍࡿࡇ࡜࡛ࠊ౫Ꮡᛶ⸆≀ࡢ᭷ᐖᛶ࡜ࡋ࡚⸆≀౫Ꮡࡢ◊✲ࠊ᭷⏝ᛶ࡜ࡋ࡚㙠③࠾ࡼࡧⓎ㐩㞀ᐖࡢ◊✲ࢆ㐍ࡵࡓࠋලయⓗ࡟ࡣࠊࠕ⸆≀౫Ꮡ἞⒪ἲ࠾ࡼࡧண
㜵ἲࡢᥦ᱌ࠖࠊࠕࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ἲࡢᐇ⌧ࠖࠊࠕ᪂つⓎ㐩㞀ᐖ἞⒪ἲࡢᥦ᱌ࠖ࡜࠸࠺ࠊࡘࡢ᫂☜࡞♫఍㑏ඖ࡛ࣞ࣋ࣝࡢ┠ᶆࢆタᐃࡋࠊศᏊࣞ࣋ࣝࠊື≀ࣞ࣋ࣝࠊࣄࢺࣞ࣋
ࣝࠊ♫఍㑏ඖࣞ࣋ࣝࡢ◊✲ࢆ᭷ᶵⓗ࡟Ⓨᒎࡉࡏࡓࠋ  ᴫせ୺࡞◊✲ᡂᯝ 

－ 27 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ  ᴫせ࣭➽ࢪࢫࢺࣟࣇ࢕࣮ࡣཌປ┬ᣦᣦᐃ㞴⑓ࡢ㑇ఏᛶ⑌ᝈ࡛ࠊ➽⫗ࡀ㐍⾜ᛶ࡟ⴎ⦰ࡋṚ࡟⮳ࡿ㞴⑓࡛࠶ࡿࠋࡲࡓࠊ⫶⫶⭠⑌ᝈࡸ⓶⓶⭵⑓࡞࡝ࡣ
⌧௦♫♫఍࡟࠾࠸࡚ᙉ࠸㛵ᚰࢆ㞟ࡵࡿࠋ࣭ࡇࢀࡽ⑌ᝈࡢ἞
἞⒪࣭デ᩿ࡣࠊ♫఍ⓗ࡟኱ࡁ࡞ᚲ
ᚲせᛶ࡜⥭
⥭ᛴᛶࢆᣢ
ࡕከ㠃ⓗ࡞࢔ࣉ࣮ࣟࢳࡀ㔜せ࡜࡞ࡿࠋ
࣭ୖグ⑌ᝈࡢ୍㒊ࡣ⣽⬊ෆࢱࣥࣃࢡ㉁ษ᩿㓝⣲ࠕ࢝࢝ࣝࣃ࢖ࣥࠖࡢᶵ
ᶵ⬟୙඲࡛Ⓨ⑕ࡍࡿࠋ
࣭୙᫂࡞㒊ศࡢከ࠸ࠕ࢝ࣝࣃ࢖ࣥࠖࡢ⏕⏕⌮ᶵ⬟࡜㛵㐃⑌ᝈࡢⓎⓎ⑕ཎᅉ࣭ᶵᵓࢆゎ᫂ࡋࠊ἞἞⒪࣭デ᩿࡬ࡢᒎ㛤ࢆ┠ᣦࡍࠋ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ BBA Proteins and Proteomics   
࣭ Sci Transl Med   HDDX
࣭ Neuromuscul Disord   
࣭ Nat Rev Drug Disc  
࣭ J Biol Chem  
࣭ Mol Cell Proteomics  
㸦௨ୗࡢᏛ఍࡟࠾࠸࡚ᡂᯝࢆⓎ⾲㸧࣭ ➨ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍  ᶓ὾࣭ ᪥ᮏ➽Ꮫ఍➨㸳ᅇᏛ⾡㞟఍  ᮾி࣭ )$6(%6XPPHU5HVHDUFK&RQIHUHQFHV7KH%LRORJ\RI&DOSDLQVLQ
+HDOWKDQG'LVHDVH $VLORPHU &$86$   ᅜෆእࡢ◊✲≧ἣ࢝ࣝࣃ࢖ࣥࢆྵࡴࢱࣥࣃࢡ㉁ศゎ⣔ࡣୡ⏺୰࡛άⓎ࡟◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿศ㔝࡛࠶ࡾࠊᵝࠎ࡞ࣄࢺ⑌ᝈࡢ἞⒪ᶆⓗ࡜ࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿࠋ≉࡟ࠊ࢝ࣝࣃ࢖ࣥ㑇ఏᏊኚ␗࡟ࡼࡿࣄࢺ⑌ᝈࡢ◊✲࡜ࡋ࡚ࡣࠊ➽ࢪࢫࢺࣟࣇ࢕࣮ࠊ㣗㐨⅖ࠊ║⑌ᝈࠊ⢾ᒀ⑓ࡀୡ⏺ⓗ࡟┒ࢇ࡛࠶ࡿࠋᙜࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⏕໬Ꮫⓗ࡞࢝ࣝࣃ࢖ࣥࡢ⏕⌮ᶵ⬟ゎᯒࠊ࢝ࣝࣃ࢖ࣥ࡜௚ࡢࢱࣥࣃࢡ㉁ᶵ⬟ಟ㣭ࢩࢫࢸ࣒࡜ࡢࢡࣟࢫࢺ࣮
ࢡゎ᫂ࢆ୰ᚰ࡟ࠊ➽ࢪࢫࢺࣟࣇ࢕࣮࠾ࡼࡧ⓶⭵⑓࡟࠾ࡅࡿ࢝ࣝࣃ࢖
ࣥࡢᙺ๭ࢆ◊✲ࡋ࡚࠸ࡿࠋ࢝ࣝࣃ࢖ࣥ୙඲࡟ࡼࡿ➽ࢪࢫࢺࣟࣇ࢕࣮
࡟ࡘ࠸࡚ࡣࠊⓎ⑕ᶵᵓゎ᫂ࠊデ᩿࣭἞⒪࡬ࡢᛂ⏝࡬࡜⧅ࡀࡿ▱ぢ࡟ࡘ࠸࡚ࠊ◊✲⪅ࡔࡅ࡛࡞ࡃᝈ⪅ᅋయ㸦⡿ᅜ࣭(8㸧ࢆྵࡴ᝟ሗ஺᥮ࡢ
ሙࡀ☜❧ࡉࢀ࡚ࡁ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ ◊  ✲ᮇ  㛫࣭  ◊✲  ⪅ྡ  ➼   ᡂᯝࡢᴫせ  ◊✲ᮇ㛫➽ࢪࢫࢺࣟࣇ࢕࣮࡜࢝ࣝࣃ࢖ࣥ࡜ࡢ㛵ಀ࡟ຍ࠼࡚ࠊ࢝ࣝࣃ࢖ࣥࡢ᪂ࡓ ᖺ᭶㹼ᖺ᭶
࡞ᵓ㐀ᶵ⬟┦㛵ࠊไᚚᶵᵓࢆ♧၀ࡍࡿ▱ぢࢆᚓࡓࠋ
㸦ᖺ㛫㸧
ᖺ᭶㹼ᖺ᭶
㦵᱁➽࡟Ⓨ⌧ࡍࡿ࢝ࣝࣃ࢖ࣥ㸦&$31㸧㸦ᖺࣨ᭶㛫㸧 
࣭&$31ᶵ⬟Ḟᦆ㸦ࣀࣀ ࢵࢡ ࢖ࣥ ., ࠊ ࣀ ࢵ ࢡ ࢔ ࢘ ࢺ .2 㸧࣐࢘ࢫ࡛ࡣࠊ➽ࢪࢫࢺࣟࣇ࢕࣮⑕≧ࡀ㢧ⴭ࡟࡞ࡿ௨๓ࡢ⏕⫱ึᮇ࡟ࠊ➽⧄⥔  ◊✲⪅ྡᆺࡢᡂ⇍㐜ᘏ࠾ࡼࡧࠊ≉␗ⓗ࡞ศᏊ⩌ࡢⓎ⌧ኚືࡀ⏕ࡌࡿࠋᑠ㔝ᘺᏊ࣭➽⣽⬊࡟Ꮡᅾࡍࡿ࢝ࣝࣃ࢖ࣥࡣࠊ࣍ࣔ㸱㔞య࡜ࡋ࡚ࡶᏑᅾࡋࠊάᛶ
⛙ ຾ᚿ
ࢆⓎ᥹ࡍࡿࠋ
኱ෆྐᏊ⫶⭠࡟Ⓨ⌧ࡍࡿ*࢝ࣝࣃ࢖ࣥ㸦&$31&$31」ྜయ㸧㔝ཱྀ࠶ࡸ 
࣭&$31&$31ࡢ㑇ఏᏊኚ␗ࡀ⑌ᝈⓎ⑕ࡢཎᅉೃ⿵࡛࠶ࡿྍ⬟ᛶ࡟ࡘ࠸࡚ඹྠ◊✲ࢆᐇ⾜ࡋࠊᮍ▱ࡢ⤌⧊Ⓨ⌧ࣃࢱ࣮ࣥࢆぢฟࡋࡓࠋሗ࿌ 㸦◊✲⿵ຓ㸧ࡉࢀࡓኚ␗ࡀ*࢝ࣝࣃ࢖ࣥࡢάᛶపୗࢆᘬࡁ㉳ࡇࡍྍ⬟ᛶࢆぢฟࡋ ᅵ஭ዉ✑Ꮚ❧㔝⋹Ꮚࡓࠋࡲࡓࠊ⥺⥔⑕ࡢ៮ᝏᅉᏊ࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
ࡑࡢ௚ࡢ࢝ࣝࣃ࢖ࣥ࡟ࡘ࠸࡚
㸦༠ຊ◊✲ဨ㸧࣭ᖺࡼࡾࠊ࢙࢘ࣈୖ࡛බ㛤ࡋࡓ࢝ࣝࣃ࢖ࣥཬࡧ࢝ࣝࣃ࢖ࣥ࡟ࡼ♞Ἴ୍ኵࡿษษ ᩿㒊఩ண ჾࢆᨵゞࡋࠊ᪂ࡋ࠸ண ࢔ࣝࢦࣜࢬ࣒ࢆ௜ຍࡍࡿ࡜
ᑿᔱᏕ୍࡜ࡶ࡟ࡼࡾ౑࠸ࡸࡍ࠸ࢹࢨ࢖ࣥࢆ᭦᪂ࡋࡓࠋᒣᮏ ᆂ
࣭࢝ࣝࣃ࢖ࣥࠊཬࡧࠊ࢝࢝ ࣝࣃ࢖ࣥ࡟ࡘ࠸࡚ࠊᇶ㉁ೃ⿵ࢱࣥࣃࢡ㉁ศゎ࡟㛵ࡍࡿᵓ㐀ᶵ⬟┦㛵ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
㸦ᐈဨ◊✲ဨ㸧኱ᾏ ᚸ  ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࢝ࣝࣃ࢖ࣥࡢᵝࠎ࡞┦஫స⏝ᙧᘧࢆ⪃៖ࡋࠊྛ࢝ࣝࣃ࢖ࣥࡢ㑇ఏᏊ ᨵኚ࣐࢘ࢫࡢ⾲⌧ᆺゎᯒࢆࡍࡍࡵࡿࠋ⌧ᅾࠊ་Ꮫ◊࡟ᑟධࡉࢀ࡚࠸ࡿ
ᵝࠎ࡞ࢩࢫࢸ࣒㸦ࢱࣥࣃࢡ㉁ཬࡧ㑇ఏᏊⓎ⌧ࡸࠊ⣽⬊ᙧែࡢゎᯒࢶ࣮ࣝ㸧ࢆ✚ᴟⓗ࡟ά⏝ࡍࡿ࡜࡜ࡶ࡟ࠊᡤෆእ࡟࠾ࡅࡿ᪂ࡓ࡞ඹྠ◊✲ࢆᒎ㛤ࡋࡘࡘ࠶ࡿࠋ࢝ࣝࣃ࢖ࣥ୙඲࡟ࡼࡿ⑌
⑌ ᝈࡢⓎ⑕ᶵᵓࢆศᏊࣞ࣋ࣝ
࡛᫂ࡽ࠿࡟ࡋࠊ㛵㐃ࡍࡿ⑌⑌ ᝈࡢデ᩿࣭἞⒪࡟࠾࠸࡚ὀ┠ࡍ࡭ࡁ⌧㇟࣭ศᏊࢆ᫂☜࡟♧ࡍࡇ࡜ࢆ┠ᣦࡍࠋ◊        ✲       ᡂ       ᯝ ࢝ࣝࣃ࢖ࣥᶵ⬟୙඲࡟ࡼࡿ⑌ᝈࡢⓎ⑕ศᏊᶵᵓࡢゎ᫂㸭࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠ㔝ᘺᏊ㸧㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 28 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊       ✲       ᡂ       ᯝ


◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
ࣘࣅ࢟ࢳࣥࢩࢫࢸ࣒ࡢ␗ᖖ࡜⑌ᝈ㸭ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᯇ⏣᠇அ㸧㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ(3)ᅜෆእࡢ◊✲≧ἣࣘࣅ࢟ࢳࣥ㛵㐃ᅉᏊࠊ≉࡟ࣘࣅ࢟ࢳࣥ࢟ࢼ࣮ࢮ PINK1 ࡜ࣘࣅ࢟ࢳࣥ㐃⤖㓝⣲ Parkin ࡢ◊✲ࡣᅜෆእ࡛⃭ࡋࡃ➇ྜࡋ࡚࠸ࡿ≧ἣࡔࡀࠊศᏊ⏕≀Ꮫ࣭⏕໬Ꮫ㡿ᇦ࡛ࡣ᭱ඛ➃◊✲ࢆᒎ㛤ࡋ࡚࠸ࡿࠋDJ-1࡟ࡘ࠸࡚ࡣࠕ࢔ࣝࢹࣄࢻ௦ㅰ࡜ࣃ࣮࢟ࣥ
ࢯࣥ⑓ࠖ࡜࠸࠺⊂⮬ࡢษࡾཱྀ࡛◊✲ࢆ⥆ࡅ࡚࠸ࡿࠋ

(1)(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Parkinࡢゐ፹ࡍࡿࣘࣅ࢟ࢳࣥ໬࡜࣮࢜ࢺࣇ࢓ࢪ࣮ศゎࢆࣜࣥࢡࡉࡏࡿᅉᏊ࡜ࠊࡑࡢศᏊᶵᵓࢆゎ᫂ࡍࡿࠋ࣭ 㑇ఏᏊᨵኚ࣐࢘ࢫࢆ⏝࠸࡚ࠊParkinࡢゐ፹ࡍࡿࣘࣅ࢟ࢳࣥ໬ࡢ
⏕⌮ⓗព⩏ࢆ in vivo ࡛ゎ᫂ࡍࡿࠋ࣭ DJ-1ࡢศᏊᶵ⬟࡜࣑ࢺࢥࣥࢻࣜ࢔ရ㉁⟶⌮࡟࠾ࡅࡿᙺ๭ࢆ᫂
ࡽ࠿࡟ࡍࡿࠋ

ᴫせ(1) ᡂᯝࡢᴫせ(1) ◊✲ᮇ㛫ࣘࣅ࢟ࢳࣥࢩࢫࢸ࣒ࡢ◚⥢ࡀᵝࠎ࡞⑌ᝈࢆᘬࡁ㉳ࡇࡍࡇ࡜ ࣭ ࣑ࢺࢥࣥࢻࣜ࢔ࡢရ㉁⟶⌮ࡣࠊ⏕ᾭྠࡌ⣽⬊ࢆ౑࠸⥆ࡅ࡞ࡅ 2015ᖺ4᭶㹼2020ᖺ3᭶ࡀ᫂ࡽ࠿࡜࡞ࡾࡘࡘ࠶ࡿࡀࠊࡑࡢ⑓ែⓎ⑕࣓࢝ࢽࢬ࣒ࡣᮍࡔ
ࢀࡤ࡞ࡽ࡞࠸⚄⤒⤌⧊ࡢ⥔ᣢ࡟ᚲ㡲࡛࠶ࡾࠊᵝࠎ࡞⚄⤒ኚᛶ 㸦5ᖺ㛫㸧ከࡃࡢㅦ࡟ໟࡲࢀ࡚࠸ࡿࠋᡃࠎࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ␗ᖖ࣑ࢺ
⑌ᝈࡢⓎ⑕ᶵᵓࢆ⪃࠼ࡿୖ࡛ࡶᴟࡵ࡚㔜せ࡞▱ぢ࡛࠶ࡿࠋࢥࣥࢻࣜ࢔࡟ᑐࡍࡿࣘࣅ࢟ࢳࣥಟ㣭ࡀࠕPINK1㑇ఏᏊኚ␗ࡸ ࣭ ᡃ ࠎ ࡣ 㑇 ఏ ᛶ ₯ ᛶ ࣃ ࣮ ࢟ ࣥ ࢯ ࣥ ⑓ (PD) ࡢ ཎ ᅉ ᅉ Ꮚ ࡛ ࠶ ࡿ (2) ◊✲⪅ྡ
PARKIN㑇ఏᏊኚ␗࡜㛵㐃ࡍࡿ㑇ఏᛶࣃ࣮࢟ࣥࢯࣥ⑓ࠖࡢⓎPINK1(ࢱࣥࣃࢡ㉁ࣜࣥ㓟໬㓝⣲)࡜Parkin(ࣘࣅ࢟ࢳࣥ㐃⤖㓝⣲) ᯇ⏣᠇அ⑕ᢚไ࡟㔜せ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࠊࡑࡢศᏊᶵᵓ࠾ࡼࡧ⑓ែ⏕ࡀᦆയ࣑ࢺࢥࣥࢻࣜ࢔ࡢࣘࣅ࢟ࢳࣥ໬ࢆ௓ࡋࡓရ㉁⟶⌮ࢆᢸ ྜྷ⏣㞷Ꮚ⌮ⓗព⩏ࡢゎ᫂ࢆ⾜࡞ࡗ࡚ࡁࡓࠋࡲࡓࠊDJ-1㑇ఏᏊኚ␗࡟⏤࠺ࡇ࡜ࢆሗ࿌ࡋ࡚ࡁࡓࠋලయⓗ࡞▱ぢ࡜ࡋ࡚ࠊᡃࠎࡣPINK1 ᒣ㔝᫭ྐ᮶ࡍࡿ␗࡞ࡿࢱ࢖ࣉࡢ㑇ఏᛶࣃ࣮࢟ࣥࢯࣥ⑓࡟ࡘ࠸࡚ࡶࠊࡑ
ࡢᇶ㉁ࡀࣘࣅ࢟ࢳ࡛ࣥ࠶ࡾࠊࣜࣥ㓟໬ࣘࣅ࢟ࢳࣥ㙐ࡀParkinࡢ ᑠ㇂㔝ྐ㤶ࡢⓎ⑕ᶵᵓࢆゎᯒࡋ࡚࠸ࡿࠋ
άᛶ໬ᅉᏊවࣞࢭࣉࢱ࣮࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ(Nature 㸦ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺ
2014; JCB 2015) ࠋ ࡲ ࡓ PINK1/Parkin ࡀ Rab5 ࣭ Rab7 ప ศ Ꮚ 㔞 ࢫࢱࢵࣇ㸧
GTPase࡜༠ຊࡋ࡚ࠊ␗ᖖ࣑ࢺࢥࣥࢻࣜ࢔ศゎ࡟ᚲせ࡞⭷ࢆ౪(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ᑠᓥ࿴⳹⤥ࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡓ(eLife 2018)ࠋࡉࡽ࡟ࠊࣘࣅ࢟ࢳ࣭ EMBO Reports, 2019ᖺᏱ⏣ᕝᬛ㔛ࣥ໬ࢆ௓ࡋࡓ᪂ࡓ࡞ࣜࢯࢯ࣮࣒ศゎᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜
࣭ J. Biol. Chem., 2019ᖺᯘ⏣෽ử
ࡶ࡟(PNAS 2017)ࠊDJ-1ࡢ≉Ṧ࡞࢔ࣝࢹࣄࢻゎẘᶵ⬟ࢆሗ࿌ࡋ࣭ eLife, 2018ᖺ
㸦◊ಟ⏕㸧
ࡓ(Sci Rep 2017)ࠋ
࣭ 5th World Parkinson Congress, 2019ᖺ࣭ Singapore Mitochondrial Mini-Symposium 2019 (Invited as ࣭ ᮏᖺᗘ(2019ᖺᗘ)࡟ࡣࠊParkin࡟ᇶ㉁≉␗ᛶࡀ↓࠸ࡇ࡜ࢆ♧ࡍ ᕝ⬥⣧Ꮚ࡜࡜ࡶ࡟(JBC 2019)ࠊ࣑ࢺࢥࣥࢻࣜ࢔࡟ᏑᅾࡍࡿMITOLࡀࠊPlenary Speaker), 2019ᖺ
㧗ᶫࡕ࠿ࡆ
Positive-feedback model ࡟࠾ࡅࡿ seed ࣘࣅ࢟ࢳࣥࡢ౪⤥࡟㈉࣭ Keystone Symposium [joint sympo. of Mitochondrial Biology㸦◊✲⿵ຓဨ㸧⊩ࡋ࡚࠸ࡿࡇ࡜ࢆ♧ࡋࡓ(JBC 2019)ࠋࡉࡽ࡟ࠊParkin࡟ࡼࡗ࡚(Z1) and Selective Autophagy (Z2)], 2018ᖺࣘࣅ࢟ࢳࣥ໬ࡉࢀࡓMITOLࡀ࣑ࢺࢥࣥࢻࣜ࢔࠿ࡽ࣌ࣝ࢜࢟ࢩ
ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2018ᖺᖺ ᗘ⏕໬Ꮫ఍ዡບ㈹࣭ ➨ 91ᅇࢯ࣮࣒࡟⛣⾜ࡍࡿࡇ࡜ࢆぢฟࡋࡓ(EMBO Rep 2019)ࠋ
ཷ ㈹ㅮ₇, 2018ᖺ୺࡞◊✲ᡂᯝ 

－ 29 －

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Exp. Hematol., 44: 68-74, 2016.
࣭ PLoS ONE, 11: e0157187, 2016.
࣭ Genes Cells, 22: 71-83, 2017.
࣭ EBioMedicine, 24: 247-256, 2017.
࣭ Biochem. Biophys. Res. Commun., 495: 2310-2316, 2018.
࣭ Cancer Sci., 109: 2479-2489, 2018.
࣭ Genes Cells, 23: 753-766, 2018.
࣭ Int. J. Dev. Biol., 63: 29-35, 2019.
࣭ Biochem. Biophys. Res. Commun., 512: 399-404, 2019.
࣭ Biochem. Biophys. Res. Commun., 513: 701-707, 2019.
࣭ Micromachines, 11: 305, 2020.



(3)ᅜෆእࡢ◊✲≧ἣࣄࢺiPS⣽⬊ࢆ⏝࠸ࡓ⾑ᾮ෌⏕་⒪࡟ࡘ࠸࡚ࡣࠊᕧ᰾⌫๓㥑⣽⬊ᰴࢆ⏝࠸ࡓ⾑ᑠᯈ〇㐀ࡀᐇ⏝໬࡟ྥ࠿ࡗ࡚࠸ࡿࡀࠊ㐀⾑ᖿ⣽⬊࡟ࡘ࠸࡚ࡣࡲࡔᡂຌࡋ࡚࠸࡞࠸ࠋḟ࡟ࠊᛴᛶTࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓(T-ALL)࡟ᑐࡍࡿ἞⒪⸆࡜ࡋ࡚ࡣࠊḢ⡿࡟࡚
MYCࡢάᛶ㜼ᐖ๣➼ࡢ⮫ᗋヨ㦂ࡀ⾜ࢃࢀ࡚࠸ࡿࠋ᭱ᚋ࡟ࠊCXCL14㛵㐃࡛ࡣCXCL12-CXCR4㍈ࢆᶆⓗ࡜ࡍࡿPlerixaforࡀㄆྍࡉࢀ࡚࠸ࡿࡀࠊࢣࣔ࢝࢖ࣥࢆ฼⏝ࡋࡓ⒴ච␿⒪ἲࡣ๓౛
ࡀ࡞࠸ࠋ

(2)

(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࣄࢺiPS⣽⬊ࢆ⏝࠸ࡓ⾑ᾮ෌⏕◊✲࡛ࡣࠊ ࣄࢺiPS⣽⬊ࡢ࢜ࣝ࢞ࣀ࢖ࢻᇵ㣴⣔ࢆᨵⰋࡋ࡚࠸ࡁࠊ㐀⾑ᖿ⣽⬊࡜ᶞ≧⣽⬊ࢆin vitroศ໬ㄏᑟ࡛ࡁࡿ᪂ࡋ࠸᪉ἲࢆ㛤Ⓨࡍࡿࠋḟ࡟ࠊT-ALL἞⒪⸆࡟ࡘ࠸࡚
ࡣࠊRa#61ࡢᶆⓗศᏊࢆྠᐃࡋࠊin vivo᭷ຠᛶ࡟ඃࢀࡓ໬ྜ≀ࡢ᥈⣴ࢆ㐍ࡵ࡚࠸ࡃࠋ᭱ᚋ࡟ࠊCXCL14࡟ࡼࡿ㐺ᛂච␿⣔ࡢ㈿ά໬
ࡣࠊᏛ⾡࣭ᛂ⏝ࡢ୧㠃࠿ࡽ⏬ᮇⓗ࡞◊✲ᡂᯝ࡛࠶ࡿࠋDNAㄆ㆑ࡢᵓ㐀ⓗᇶ┙ࡸཷᐜయࡢゎ᫂ࢆ㐍ࡵࡿ࡜ྠ᫬࡟ࠊ⒴ච␿ࢆᙉ໬ࡍࡿ
CpG DNA/CXCL14」ྜయ࢔ࢪࣗࣂࣥࢺࡢ㛤Ⓨ࡟ᣮᡓࡋ࡚࠸ࡃࠋ௚࡟ࡶ኱⭠⒴ࡢⓎ⑕࡜ᐦ᥋࡟㛵ࢃࡿDDX1ࡢ◊✲ࡶ㐍ᒎࡋ࡚࠸ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺ◊✲ࡢᡂᯝࡣࠊ⥲ྜⓗ࡟⾑ᾮ෌⏕་⒪࡜ࡀࢇ἞
⒪ἲࡢⓎᒎ࡟⧅ࡀࡗ࡚࠸ࡃࡶࡢ࡜ᮇᚅࡉࢀࡿࠋ

ᡂᯝࡢᴫせ୍ࡘ┠ࡢㄢ㢟࡜ࡋ࡚ࠊࣄࢺiPS⣽⬊ࡢศ໬ㄏᑟࣉࣟࢺࢥ࣮ࣝࡢ
ᨵⰋ࡟ྲྀࡾ⤌ࢇࡔࠋࡲࡎࠊศ໬ㄏᑟ㛤ጞ0-1᪥┠࡟GSK3E㜼ᐖ๣ࢆῧຍࡍࡿ࡜ศ໬ㄏᑟ⋡ࡀ๻ⓗ࡟㧗ࡲࡿࡇ࡜ࢆⓎぢࡋࡓࠋḟ࡟ࠊࣄࢺiPS⣽⬊⏤᮶ࡢ⬇ᵝయࢆ࢝ࣝࢳ࣮ࣕ࢖ࣥࢧ࣮ࢺࡢୖ࡟
⨨࠸࡚࢜ࣝ࢞ࣀ࢖ࢻᇵ㣴ࡋ࡚ࡳࡓ࡜ࡇࢁࠊࣄࢺCD34+CD45+ 㐀⾑๓㥑⣽⬊ࡢศ໬ㄏᑟຠ⋡ࡀ㣕㌍ⓗ࡟ྥୖࡋࡓࠋ஧ࡘ┠ࡢㄢ㢟࡛ࡣࠊࣄࢺT-ALL⣽⬊ᰴࡢቑṪࢆ≉␗ⓗ࡟ᢚไࡍࡿኳ↛໬ྜ≀
31D-F005ࢆྠᐃࡋࠊࡑࢀࡀT-ALLᝈ⪅⏤᮶ࡢึ௦ⓑ⾑⑓⣽⬊ࡢቑṪࡶᢚไ࡛ࡁࡿࡇ࡜ࢆド᫂ࡋࡓࠋࡉࡽ࡟ࠊྜᡂᒎ㛤◊✲࡟ࡼ
ࡗ࡚ࠊ31D-F005ࡼࡾඃࢀࡓᢠࡀࢇάᛶࢆ᭷ࡍࡿ᪂ወࡢపศᏊ໬
ྜ≀Ra#61ࡢྜᡂ࡟ᡂຌࡋࡓ㸦≉チฟ㢪2019-218270㸧ࠋ୕ࡘ┠ࡢㄢ㢟࡛ࡣࠊCXCL14ࡀCpG DNA࡟㧗ぶ࿴ᛶ⤖ྜࡋࠊࡑࢀࢆᶞ
≧⣽⬊ෆ࡬㐠ࡧ㎸ࡴࡇ࡜࡛TLR9ࢆ௓ࡋࡓ㐺ᛂච␿⣔ࢆάᛶ໬ࡍ
ࡿࡇ࡜ࢆⓎぢࡋࡓ㸦≉チฟ㢪2016-091183㸧ࠋCXCL14-KO࣐࢘ࢫࡣࠊ࣓ࣛࣀ࣮࣐ࡢቑṪ࡜≉ᐃࡢ⣽⳦ឤᰁ࡟㧗ឤཷᛶ࡛࠶ࡗ
ࡓࠋࡉࡽ࡟ࠊୖグࡢᛂ⟅࡟㛵ࢃࡗ࡚࠸ࡿCpG DNA-CXCL14ཷᐜయೃ⿵ศᏊࡢྠᐃ࡟ᡂຌࡋࡓࠋ
(1)

ᴫせ㐀⾑ᖿ⣽⬊ࡣࠊࡍ࡭࡚ࡢච␿ᢸᙜ⣽⬊ࢆ⏘ࡳฟࡋ࡚ࡃࢀࡿࠊ
⏕య࡟ᚲ㡲࡞⣽⬊࡛࠶ࡿࠋ೺ᖖேࡸᝈ⪅ࡢiPS⣽⬊ᰴ࠿ࡽࠊ㐀⾑ᖿ⣽⬊࣭⾑ᑠᯈ࣭⣽⬊㞀ᐖᛶT⣽⬊ࢆศ໬ㄏᑟ࡛ࡁࡿࡼ࠺
࡟࡞ࢀࡤࠊ⾑ᾮ㛵㐃㞴⑓࡟ᑐࡍࡿ἞⒪ἲࡢ㑅ᢥ⫥ࡀ኱ᖜ࡟ᗈ
ࡀࡿ࡜ᮇᚅࡉࢀࡿࠋ୍᪉ࠊṚஸ⋡㸯఩ࡢ ࡀࢇඞ᭹࡟ྥࡅ࡚
ࡣࠊᖿ⣽⬊㛵㐃ศᏊࢆᶆⓗ࡜ࡍࡿᢠࡀࢇ๣ࡀὀ┠ࡉࢀ࡚࠸ࡿࠋ
ᮏ◊✲࡛ࡣࠊࣄࢺiPS⣽⬊࠿ࡽᶵ⬟ⓗ࡞⾑ᾮ⣽⬊ࢆ ຠ⋡ⓗ࡟సࡾฟࡍ᪉ἲࠊ୪ࡧ࡟᪂ࡋ࠸ࡀࢇ἞⒪ἲ࣭デ᩿ἲࡢ㛤Ⓨ࡟ᣮࡴࠋ(1)㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ(2) ◊✲⪅ྡཎ Ꮥᙪ
໭ᓥ೺஧✀Ꮚᓥᖾ♸
㕥ᮌ㍤ᙪ
ᮧᒸṇᩄ
ᖹᯇᜤᏊ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
ᖿ⣽⬊ࢆ฼⏝ࡋࡓ⾑ᾮ෌⏕་⒪ᢏ⾡࡜ࡀࢇ἞⒪ἲࡢ㛤Ⓨ㸭ᖿ⣽⬊ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ཎ Ꮥᙪ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 30 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊       ✲       ᡂ       ᯝඹྠ◊✲⪅
Bruce Conklin(Gladstone Institutes, USA)
Nathan Salomonis(Cincinnati Children's
Hospital, USA)(2) ◊✲⪅ྡ
ᐑᒸభ୍㑻
ຍ⸨᭸Ꮚ
㧗ᶫ ๛
チ ⤬ⲓ

(1) ◊✲ᮇ㛫
2016ᖺ4᭶㹼2020ᖺ3᭶
㸦4ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼


iPS⣽⬊ࡢࢤࣀ࣒⦅㞟࡟ࡼࡿ⑌ᝈࡢ἞⒪ἲࡢ㛤Ⓨ㸭෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᐑᒸభ୍㑻㸧(1) ᡂᯝࡢᴫせ࣭ Cas9࡜DNAࡢ㛫ࡢ┦஫స⏝ᵝᘧ࡟ᙳ㡪ࢆཬࡰࡍⅬኚ␗ࢆᣢࡘᨵኚᆺ
Cas9࡟ࡼࡿࠊᩘ༓ሷᇶᑐࡢ DNA᩿∦ࡢࣀࢵࢡ࢖ࣥຠ⋡ࡢྥୖࡀࠊ
HEK293T⣽⬊࡟ຍ࠼࡚ࠊࣄࢺiPS⣽⬊࡟࠾࠸࡚ࡶྠᵝ࡟ほᐹࡉࢀࡓࠋ
ᨵኚᆺCas9࡟ࡼࡿDNA⤌᥮࠼ࢆ௓ࡋࡓࢤࣀ࣒⦅㞟ຠ⋡ࡢྥୖࡀࠊ⣽⬊✀࡟౫Ꮡࡋ࡞࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ࣭ ࢤࣀ࣒⦅㞟⤖ᯝࢆEGFP࡜mCherryࡢ⺯ග࡟ࡼࡗ᳨࡚ฟ࡛ࡁࡿ࣏࣮ࣞ
ࢱ࣮K562⣽⬊ࢆᶞ❧ࡋࡓࠋ࣭ ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⏝࠸࡚ࠊ೺ᖖ⪅⏤᮶iPS⣽⬊࡟ᚰ➽⑕ࡢཎᅉ࡜࡞ࡿ
RBM20࡜࠸࠺㑇ఏᏊࡢኚ␗ࢆᑟධࡋࠊࡉࡽ࡟FLAGࢱࢢࢆCᮎ➃࡟௜(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ຍࡋࡓࠋࡑࡢ⣽⬊ࢆᚰ➽⣽⬊࡬࡜ศ໬ㄏᑟࡋࠊFLAGࢱࢢࢆ௓ࡋ࡚㔝Ⓨ⾲Ꮫ఍⏕ᆺRBM20࠾ࡼࡧኚ␗RBM20ࢱࣥࣃࢡ㉁ࢆච␿ỿ㝆ࡋࠊRBM20࡟⤖ྜࡍࡿRNAศᏊࢆḟୡ௦ࢩ࣮ࢡ࢚ࣥࢩࣥࢢ࡟ࡼࡾ⥙⨶ⓗ࡟ྠᐃࡋࡓࠋ
࣭ Miyaoka Y. et al., Genome Editing in Human iPS Cells to Cureࡑࡢ⤖ᯝࠊ㔝⏕ᆺRBM20ࡣᚰ➽⣽⬊ࡢศ໬ࡸᶵ⬟࡟㛵ࢃࡿ㑇ఏᏊࡢ
and Study Disease. The 4th TransMed-VN Conference 2019
(Hanoi, Vietnam)
mRNAࡢ࢖ࣥࢺࣟࣥ࡟⤖ྜࡋ࡚࠸ࡿࡀࠊኚ␗RBM20ࡣ㠀≉␗ⓗ࡟ከᩘࡢmRNA࡟ࡑࡢ3’UTRࢆ௓ࡋ࡚⤖ྜࡋ࡚࠸ࡓࠋࡇࡢ␗ᖖ࡞RBM20࡜
࣭ Takahashi G, Mori H, Ishiguro S, Yachie N, Miyaoka Y. Precise
mRNA࡜ࡢ⤖ྜࡀࠊRBM20ኚ␗࡟ࡼࡿᚰ➽⑕Ⓨ⑕࡟ࡘ࡞ࡀࡿࡇ࡜ࡀ♧Deletion Mutagenesis by Dual Cas12a DNA Cleavage. Frontiers၀ࡉࢀࡓࠋin Genome Engineering 2019 (⚄ᡞ)
࣭ Miyaoka Y. et al., Genome-Edited iPSC and Pig Cardiomyopathy ࣭ 㑇ఏᛶ⫢⑌ᝈ࡛࠶ࡿ࢘࢕ࣝࢯࣥ⑓ࡢᝈ⪅⏤᮶iPS⣽⬊ࡀᣢࡘࠊཎᅉኚ
␗ࡢATP7B࡜࠸࠺㑇ఏᏊࡢR778LⅬኚ␗ࢆಟṇࡋࠊ⫢⣽⬊࡬࡜ศ໬ࡉ
Models Reveal Mutant RBM20 Forms Mislocalized Granules toࡏࡓࠋ࢙࢘ࢫࢱࣥࣈࣟࢵࢺࡢ᮲௳ࢆ᭱㐺໬ࡋࡓ࡜ࡇࢁࠊR778Lኚ␗࡟
Dominantly Disrupt Global Splicing. ISSCR 2019 Annual
ࡼࡗ࡚ATP7Bࢱࣥࣃࢡ㉁㔞ࡀపୗࡍࡿࡇ࡜ࡀࠊ᫂☜࡟♧ࡉࢀࡓࠋࡉ
Meeting (Los Angeles, USA)ࡽ࡟ࠊ㔝⏕ᆺࣄࢺiPS⣽⬊࡬ࡢATP7B R778Lኚ␗ࡢᑟධࡶ㛤ጞࡋࡓࠋ࣭ ᐑᒸభ୍㑻ࡽ ࢤࣀ࣒⦅㞟iPS⣽⬊࠾ࡼࡧࣈࢱࢆ⏝࠸ࡓࢫࣉ(2)
௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࣛ࢖ࢩࣥࢢᅉᏊRBM20ࡢኚ␗࡟ࡼࡿᚰ➽⑕Ⓨ⑕ᶵᗎࡢゎᯒ࣭ ⺯ග࣏࣮ࣞࢱ࣮K562⣽⬊ࢆ⏝࠸ࡓࠊࢤࣀ࣒࣡࢖ࢻ࡞⤌᥮࠼ಟ᚟ಁ㐍➨4ᅇ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍ᖺ఍㸦ᮾி㸧ᅉᏊࡢࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡼࡗ࡚ࠊᘬࡁ⥆ࡁࡼࡾṇ☜࡞ࢤࣀ࣒⦅㞟ࢆ࣭ ᐑᒸభ୍㑻 ࣇ࢓ࣈ࣮ࣜ⑓ࡢiPS⣽⬊⛣᳜἞⒪ࢆ┠ᣦࡋ࡚࠸ࡶࡓࡽࡍᢏ⾡㛤Ⓨࢆ㐍ࡵࡿࠋࡲࡍ ᫂἞⸆⛉኱Ꮫ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘㸦ᮾி㸧࣭ RBM20ࡢኚ␗ࡀᚰ➽⣽⬊࡟ࡶࡓࡽࡍᙳ㡪࡟ࡘ࠸࡚ࠊศᏊࣞ࣋ࣝࡢゎᯒࢆࡉࡽ࡟㐍ࡵࡿࡇ࡜࡛ࠊᚰ➽⑕Ⓨ⑕ᶵᗎࡢ⌮ゎࢆ῝ࡵࠊ᪂ࡓ࡞἞
(3) ᅜෆእࡢ◊✲≧ἣ⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡿࠋ
ᅜෆእ࡛ࠊiPS⣽⬊࡜ࢤࣀ࣒⦅㞟ࢆ⤌ࡳྜࢃࡏࡓ◊✲ࡣ┒࣭ ࢘࢕ࣝࢯࣥ⑓ཎᅉ㑇ఏᏊࡢATP7Bࡣ㖡ࢺࣛࣥࢫ࣏࣮ࢱ࣮࡛࠶ࡿࡓ
ࢇ࡟㐍ࡵࡽࢀ࡚࠾ࡾࠊᇶ♏◊✲ࡸᢏ⾡㛤Ⓨ࡟ຍ࠼ࠊ⮫ᗋᛂ⏝
ࡵࠊATP7Bኚ␗ࢆಟṇࡋࡓiPS⣽⬊⏤᮶ࡢ⫢⮚⣽⬊ࡀᣢࡘ㖡㍺㏦ᶵ⬟ࢆホ౯ࡍࡿࠋⅬኚ␗ࡀATP7Bࢱࣥࣃࢡ㉁ࡢᏳᐃᛶࡸ⣽⬊ෆᒁᅾࢆኚ
࡟ྥࡅࡓྲྀ⤌ࡳࡶ㐍ࢇ࡛࠸ࡿࠋ
໬ࡉࡏࡿᶵᵓࢆゎᯒࡍࡿࠋ(1)

ᴫせiPS⣽⬊࡟ࡣᵝࠎ࡞་⒪ᛂ⏝ࡀᮇᚅࡉࢀࠊ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࡀࠊࡑࡢࢤࣀ࣒ࢆ᧯సࡍࡿࡇ࡜ࡢᅔ㞴ࡉࡀ㧗࠸㞀ቨ࡜࡞ࡗ࡚ࡁࡓࠋࡋ࠿ࡋࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓎᒎ࡟ࡼࡾࠊࡑ
ࡢ㞀ቨࡶྲྀࡾᡶࢃࢀࡘࡘ࠶ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊiPS⣽⬊࡜ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊ㑇ఏᛶ⑌ᝈࣔࢹࣝస〇࡟ࡼࡿ⑌ᝈࡢⓎ⑕ᶵᗎࡢゎᯒࠊ࠾ࡼࡧ⑌ᝈࡢཎᅉ࡜࡞ࡿኚ␗ࢆಟṇࡋࡓiPS⣽⬊࡟ࡼࡿ⣽⬊⛣᳜἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ 

－ 31 －ㄽᩥᥖ㍕࣭Nature     ࣭Nat Med    ⥲ㄝ࣭Int ImmunolLQSUHVV  
࣭J Biochem    
࣭Semin Immunopathol    ࣭Neurochem IntSLL6    ࣭⚄⤒໬Ꮫ     ࣭᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍㞧ㄅ     ࣭᪥ᮏ⸆⌮Ꮫ㞧ㄅ     ࣭⏕໬Ꮫ     
Ꮫ఍ㅮ₇㸦ᣍᚅㅮ₇㸧࣭➨ᅇ᪥ᮏච␿Ꮫ఍኱఍
࣭➨ᅇ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍኱఍
࣭1HXUR ᪥ᮏ⚄⤒⛉Ꮫ኱఍᪥ᮏ⚄⤒໬Ꮫ኱఍ 
࣭%UDLQ ᅜ㝿⬻ᚠ⎔௦ㅰᏛ఍኱఍ ࣭➨ᅇ᪥ᮏ⅖⑕࣭෌⏕་Ꮫ఍࣭➨ᅇ᪥ᮏᢠຍ㱋་Ꮫ఍⥲఍࣭  ᅜෆእࡢ◊✲≧ἣᖺᗘࡣ⚄⤒ච␿࡟㛵㐃ࡍࡿㄽᩥࡀWRSMRXUQDO࡟┦ḟ࠸࡛ሗ࿌ࡉࢀ࡚࠾ࡾࠊୡ⏺ⓗ㛵ᚰࡀ㧗ࡲࡗ࡚࠸ࡿࠋࡑࡢࡼ࠺࡞
୰࡛ࠊ⬻᱾ሰᚋࡢ⚄⤒ච␿Ꮫࢆ⚄⤒ಟ᚟Ꮫ࡬࡜Ⓨᒎࡉࡏࡿᙜ
ࣉࣟࢪ࢙ࢡࢺ◊✲ࡣඛ㥑ⓗ࡛⊂๰ⓗ࡛࠶ࡿࠋ

௨ୖࡢ◊✲ᡂᯝࢆᅵྎ࡜ࡋ࡚ࠊ⬻᱾ሰᚋࡢ⚄⤒ᅇ㊰ࡢಟ᚟ࢆㄏᑟ
ࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࡢゎ᫂࡟ࡴࡅ࡚ᇶ┙࡜࡞ࡿ◊✲ᢏ⾡ࢆ☜❧ࡍࡿࡇ࡜ࡀ࡛ࡁ࡚࠸ࡿࠋ➨ᮇࣉࣟࢪ࢙ࢡࢺ࡛ࡣ≉࡟ࠊ⬻᱾ሰᚋࡢ⚄⤒ᅇ㊰෌ᵓ⠏ࢆ㛤ጞࠊ⤊↉ࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋ἞⒪ᛂ⏝ࡍࡿࠋ  ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ղ ⬻᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࣓࢝ࢽࢬ࣒ࡢゎ᫂⬻᱾ሰ࡟࠾࠸࡚⬡㉁ࡢືែࡣ๻ⓗ࡟ኚ໬ࡍࡿࠋᡃࠎࡣ≉࡟ࠊࣜࣥ⬡㉁࡜⬡㉁࣓ࢹ࢕࢚࣮ࢱ࣮࡟ὀ┠ࡋ࡚◊✲ࢆ㐍ࡵࠊ⬻᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࡟㛵ࢃࡿ᪂つࡢ⬻ಟ᚟ⓗ࡞⬡㉁ࢆྠᐃࡍࡿࡇ࡜࡟ᡂ
ຌࡋ࡚࠸ࡿࠋ⬻᱾ሰ࡟కࡗ࡚Ⓨ⌧ࡀኚ໬ࡍࡿ࣍ࢫ࣍ࣜࣃ࣮ࢮ$ࡢࢧࣈࢱ࢖ࣉࢆỴᐃࡋࠊࡇࢀࡽࡢḞᦆ࣐࢘ࢫࢆ⏝࠸࡚⬻᱾ሰࣔࢹࣝࢆస
〇ࡋࡓ⤖ᯝࠊJURXS ,,⩌࣍ࢫ࣍ࣜࣃ࣮ࢮ$ࡀ⬻᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࡟㛵୚ࡍࡿࡇ࡜ࢆⓎぢࡋࡓࠋ⬻᱾ሰ⤌⧊࠿ࡽ⬡㉁ࢆᢳฟࡋ
࡚㉁㔞ศᯒࢆ⾜࠸ࠊJURXS ,,⩌࣍ࢫ࣍ࣜࣃ࣮ࢮ$࡟ࡼࡗ࡚⏘⏕ࡉࢀࡿ⬡㉁௦ㅰ≀ࢆྠᐃࡋࠊ᪂つࡢ⬻ಟ᚟ⓗ࡞⬡㉁࡜ࡋ࡚Ỵᐃࡍࡿࡇ࡜
ࡀ࡛ࡁࡓࠋᘬࡁ⥆ࡁࠊᡃࠎࡀྠᐃࡋࡓ⬡㉁࡟╔┠ࡋࡓ⮫ᗋ◊✲ࢆᐇ
᪋ࡋࠊ἞⒪๣࡜ࡋ࡚ࡢ☜❧ࢆ┠ᣦࡋ࡚◊✲ࢆᐇ᪋ࡍࡿࠋ⬻ ᱾ ሰ ࡟ ࠾ ࡅ ࡿ ᪂ つ ࡢ ෆ ᅉ ᛶ ⅖ ⑕ ច ㉳ ᅉ Ꮚ ࡜ ࡋ ࡚ '-
㸦3DUN㸧ࢱࣥࣃࢡ㉁ࢆྠᐃࡋࡓࠋ'- ࡣ⬻᱾ሰᕢ࡟࠾࠸࡚⹫
⾑࡟㝗ࡗࡓ⚄⤒⣽⬊࡛⏘⏕ࡉࢀࡿᢠ㓟໬ࢱࣥࣃࢡ㉁࡛࠶ࡿࡀࠊ
⚄⤒⣽⬊ࡢ⹫⾑ቯṚ࡟కࡗ࡚⣽⬊እ࡟ᨺฟࡉࢀࠊ⬻᱾ሰᕢ࡟ᾐ
₶ࡋࡓዲ୰⌫ࡸ࣐ࢡࣟࣇ࢓࣮ࢪࢆ 7/5ࠊ7/5 ౫Ꮡⓗ࡟άᛶ໬ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ'- Ḟᦆ࣐࢘ࢫࢆ⏝࠸ࡓゎᯒ࡛ࡣࠊ⬻᱾ሰయ✚࡟ࡣኚ໬ࡣぢࡽࢀ࡞࠿ࡗࡓࡀࠊ⬻᱾ሰᕢ࡟ᾐ₶ࡋࡓච␿⣽⬊࡟ࡼࡿ⅖⑕ࡀ㍍ῶࡋ࡚࠸ࡓࠋࡇࡢࡼ࠺࡟ '- ࡣ⬻⣽⬊ෆ࡛ࡣᢠ㓟໬స⏝࡟ࡼࡾ⬻ಖㆤⓗ࡞ᙺ๭ࢆᣢࡘࡀࠊ⣽⬊እ࡟ᨺฟࡉࢀࡓ '- ࡣ⅖⑕ࢆច㉳ࡍࡿస⏝ࢆ᭷ࡍࡿࡇ࡜࠿ࡽ
⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞἞⒪ᶆⓗ࡜࡞ࡾᚓࡿࡇ࡜ࡀド࡛᫂ࡁࡓ㸦୐⏣ࡽࠊPNASLQUHYLVLRQ㸧ࠋձ ⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞⅖⑕ច㉳ᅉᏊࡢྠᐃ◊        ✲       ᡂ       ᯝ ⬻᱾ሰᚋࡢ⅖⑕ࢆಟ᚟࡟㌿᥮ࡍࡿ࣓࢝ࢽࢬ࣒ࢆࠊ⅖⑕཰᮰࡟⮳ࡽࡏࡿ⬻ෆᅉᏊࡢྠᐃࠊᦆയࡋࡓ⚄⤒ᅇ㊰ࢆಟ᚟ࡉࡏࡿᅉᏊࡢྠᐃࠊࡢ㸰ࡘࡢどⅬ࠿ࡽゎ᫂ࡍࡿࠋ  ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ◊✲ᮇ㛫ᖺ᭶㹼ᖺ᭶㸦 ᖺ㛫㸧  ◊✲⪅ྡᖖ໅◊✲ဨ
୐⏣ ᓫ
㓇஭ㄔ୍㑻ὠᒣ ῟◊  ✲ᮇ  㛫࣭  ◊✲  ⪅ྡ  ➼ ⬻༞୰࡟࠾ࡅࡿ⅖⑕࡜ಟ᚟࣓࢝ࢽࢬ࣒ࡢゎ᫂㸭⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୐⏣ ᓫ㸧  ᡂᯝࡢᴫせ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ  ᴫせ୺࡞◊✲ᡂᯝ 

－ 32 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ

㐠ື୰ᯡࡢ◊✲ࡣᮍࡔ࡟኱⬻༢⊂ࠊᑠ⬻༢⊂࠶ࡿ࠸ࡣᇶᗏ
᰾༢⊂ࢆᑐ㇟࡜ࡍࡿ◊✲ࡀᅽಽⓗ࡟ከࡃࠊࡇࢀࡽࡢ㐠ື୰ᯡࡀࢿࢵࢺ࣮࣡ࢡ࡜ࡋ࡚㐃㛵ࡍࡿᶵ⬟ཎ⌮ࢆゎ᫂ࡍࡿどⅬࡢ◊✲ࡣᏑᅾࡋ࡞࠸ࠋࡉࡽ࡟ࠊᇶ♏◊✲࡜⮫ᗋ◊✲ࡢ┦஌ຠᯝࢆ≺࠺◊✲ࡣᡃࠎࡢࢢ࣮ࣝࣉ௨እ࡟⾜ࢃࢀ࡚࠸࡞࠸ࠋࡑࡢព࿡
࡛ᡃࠎࡢ◊✲ࡣୡ⏺ⓗ࡟ぢ࡚ࡶ㠀ᖖ࡟ࣘࢽ࣮ࢡ࡞࣮࢜ࣥࣜ࣡
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ࡿ◊✲ࢆࠊ୧⪅ࡢ฼Ⅼࢆ⤌ࡳྜࢃࡏ࡚┦⿵ⓗ࡟⾜࠸ࠊ㐠ື㔝㸪ᇶᗏ᰾㸪ᑠ⬻ࡢ㸱ࡘࡢ㐠ື୰ᯡࡢᶵ⬟ཎ⌮ࢆゎ᫂ࡍࡿࠋࡑࡢᡂᯝ࡟ᇶ࡙ࡁ⑓ែࡢᐈほⓗホ౯ࢆྍ⬟࡟ࡍࡿ⚄⤒⑌ᝈ἞⒪ࢼࣅࢤ࣮ࢱ࣮ࢆ☜❧ࡍࡿࠋ  ᴫせ୺࡞◊✲ᡂᯝ   ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼x ື≀ᐇ㦂㸸 ᖺᗘ࠿ࡽ㛤ጞࡋࡓ኱⬻ᇶᗏ᰾࠾ࡼࡧ኱⬻㐠ື㔝࠿ࡽࡢ⚄⤒άືグ㘓ࡣ㡰ㄪ࡟㐍⾜ࡋ࡚࠾ࡾࠊࡇࢀࡲ࡛ࡢᑠ⬻⚄⤒ᅇ㊰࠿ࡽࡢグ㘓࡜ྜࢃࡏ࡚ࠊ኱⬻ࠊᑠ⬻ࠊᇶᗏ᰾࡜࠸࠺㐠ືࡢ୕኱୰ᯡࡀ
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ᗘ࡟ㄽᩥⓎ⾲ࡋࡓࠋᖺᗘࡣࠊࡇࡢࢩࢫࢸ࣒ࢆᑠ⬻⑌ᝈࠊᇶᗏ᰾
⑌ᝈࠊ⬻༞୰ࡢ⑓ែホ౯࡟฼⏝ࡍࡿᐇ⏝໬◊✲ࢆ⥅⥆ࡍࡿࠋࡇࡢ◊✲࡟ࡼࡾࠊ⚄⤒⑌ᝈࡢ⑓ែホ౯ࡢᐈほ໬ࡢᐇ⏝໬ࢆ᏶ᡂࡉࡏࡿࠋ  ᡂᯝࡢᴫせD  ᡃࠎࡢࢢ࣮ࣝࣉࡢᅛ᭷ࡢ◊✲࡛ᚓࡽࢀࡓ⚄⤒άືࢹ࣮ࢱ࡟ᇶ࡙ࡃᑠ
⬻ືసཎ⌮ࡢ☜❧࡟ᡂຌࡋࡓ㸸ᖺ࡟㐠ືㄢ㢟୰ࡢࢧࣝᑠ⬻ࡢධຊᒙ୰㛫ᒙฟຊᒙࡢ⚄⤒⣽⬊άືࡢグ㘓ࡀ᏶ᡂࡋ㸦7RPDWVX HW DO -
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ࡢ᥈⣴ࢆ⾜ࡗࡓࠋᑠ⬻ࡢྛࢫࢸࢵࣉ࡟࠾ࡅࡿ᝟ሗኚ᥮࡟ࡘ࠸࡚ࠊ඲
࡚ࡢ⚄⤒⣽⬊ࢹ࣮ࢱࢆ฼⏝ࡋ࡚ᵝࠎ࡞ᩘᏛⓗࣔࢹࣝࢆ᳨ドࡋࡓࠋண᝿࡟཯ࡋ࡚ձᑠ⬻ྛᒙࡢኚ᥮࢔ࣝࢦࣜࢬ࣒ࡣ༢⣧࡞⥺ᙧኚ᥮࡛ㄝ᫂
ࡉࢀ㸹ղᑠ⬻ࡢ᝟ሗኚ᥮඲యࡣࠋ࣐࢝ࣝࣥࣇ࢕ࣝࢱ࣮࡜࿧ࡤࢀࡿᕤ
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⑓ែ㏣㊧ࢆࡉࡽ࡟᥎㐍ࡋࠊղ⬨㧊ᑠ⬻ኚᛶ⑕ࡢ᪩ᮇ㸦⣽⬊⬺ⴠ๓㸧Ⓨぢ᪉ἲࡢ╔᝿ࢆᚓࡓࠋձࡣ⚄⤒⑌ᝈࡢ⑓ែᣦᶆ㸦ண ไᚚㄗᕪ
ࣇ࢕࣮ࢻࣂࢵࢡไᚚㄗᕪ㧗࿘Ἴࣀ࢖ࢬ㸧ࢆ౑࠸ࠊ౛ࡢᝈ⪅࡛㛗ᮇ
㏣㊧ࢹ࣮ࢱࢆᚓࡓࠋղ࡟ࡘ࠸࡚ࡣ๓㢌๓㔝࠿ࡽᑠ⬻ᚋ㠃࡬ࡢᙉຊ࡞
ᢞᑕ࡟ࡼࡿㄏⓎ㟁఩ࡢኚᐜࢆከࢳࣕࣥࢿࣝ⬻Ἴィ ᳨࡛ฟࡍࡿ࢔࢖
ࢹ࢕࢔ࡢ᳨ドࢆື≀ᐇ㦂࡜ࣄࢺࡢᐇ㦂᳨࡛ド୰࡛࠶ࡿࠋ◊        ✲       ᡂ       ᯝ   ◊✲ᮇ㛫ᖺ᭶㹼ᖺ᭶
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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸⟍ ៅ἞㸧㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 33 －㻌◊㻌 㻌 㻌 㻌 㻌 㻌 㻌✲㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᡂ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᯝ㻌㻌(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࠎࡀⓎぢࡋࡓ⮬↛Ⓨ⑕ NTG ࣐࣮ࣔࢭࢵࢺ࡛ࡣࠕど⚄⤒࣭どぬ㔝࡟࠾ࡅࡿ⚄⤒ᰤ㣴
ᅉᏊࡢⓎ⌧పୗࠖࠊࠕ⬻⬨㧊ᅽࡢపୗ㸦┦ᑐⓗ࡞║ᅽୖ᪼㸧ࠖࡸࠕ║⾑ὶ㔞ࡢపୗࠖ࡞࡝ࠊ⥳ෆ㞀ᝈ⪅࡟㢮ఝࡋࡓᡤぢࡀ」ᩘ☜ㄆࡉࢀ࡚࠾ࡾࠊ᭷⏝࡞ࣔࢹࣝ࡜࡞
ࡿྍ⬟ᛶࡀᮇᚅࡉࢀࡿ㸦Scientific Reports, 2019㸧ࠋࡲࡓࠊ௨ୖࡢࡼ࠺࡞⑌ᝈࣔࢹ
ࣝ࡟㛵ࡍࡿ⥲ㄝࢆᅜ㝿ⓗ࡞ᑓ㛛ㄅ࡟Ⓨ⾲ࡋࡓ㸦Br J Ophthalmol, 2019 ௚㸧ࠋ࣭ ⥳ෆ㞀἞⒪࡟࠾࠸࡚ࡣ║ᅽୗ㝆⒪ἲ࡟ຍ࠼࡚ࠊ⚄⤒ಖㆤస⏝ࢆ᭷ࡍࡿ἞⒪ἲࡢ☜❧ࡀᮃࡲࢀ࡚࠸ࡿࠋࡑࡇ࡛ cysteine ๓㥑య࡛࠶ࡿ N-acetylcysteine㸦NAC㸧ࢆ NTG
ࣔࢹࣝື≀࡟ᢞ୚ࡋࠊ⥳ෆ㞀ࡢᢚไຠᯝࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊEAAC1 Ḟᦆ࣐࢘ࢫ࡛ࡣᢠ㓟໬స⏝ࢆ᭷ࡍࡿࢢࣝࢱࢳ࢜ࣥࡢⓎ⌧ୖ᪼࡟ຍ࠼࡚ࠊ㓟໬ࢫࢺࣞࢫ࠾ࡼ
ࡧ autophagy ࡢ࣐࣮࣮࢝Ⓨ⌧㔞ࡀῶᑡࡋࠊ⥳ෆ㞀ࡢ㐍⾜ࡀᢚไࡉࢀࡓࠋཤ⑱⸆࡞࡝࡜ࡋ࡚Ᏻ඲ᛶࡀ☜ㄆࡉࢀࡓ᪤Ꮡ⸆࡛࠶ࡿ NAC ࡣࠊ⥳ෆ㞀ࡢ἞⒪࡟࠾࠸࡚᭷⏝࡞ྍ⬟ᛶࡀ࠶ࡿ㸦Cell Death and Disease, 2019㸧ࠋ࣭ DOCK8 ࡣච␿⣽⬊࡟ᙉࡃⓎ⌧ࡍࡿࢢ࢔ࢽࣥࢾࢡࣞࢳࢻ஺᥮ᅉᏊ࡛࠶ࡾࠊ㔜⑕」ྜච␿୙඲⑕࡜ࡢ㛵ಀࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊ⚄⤒⑌ᝈ࡟࠾ࡅࡿᙺ๭ࡣ୙࡛᫂࠶
ࡿࠋࡑࡇ࡛୰ᯡ⚄⤒⣔࡟࠾ࡅࡿศᕸࢆㄪ࡭ࡓ࡜ࡇࢁࠊDOCK8 ࡣ࣑ࢡࣟࢢࣜ࢔≉␗ⓗ࡟Ⓨ⌧ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋࡲࡓ࣑ࢡࣟࢢࣜ࢔ࡀ⑓ែ࡟㛵୚ࡍࡿከⓎᛶ◳໬⑕ࡢ⬻⑓⌮ᶆᮏࢆㄪ࡭ࡓ࡜ࡇࢁࠊከᩘࡢ DOCK8 㝧ᛶ࣑ࢡࣟࢢࣜ࢔ࡀほᐹࡉࢀࡓࠋḟ࡟ DOCK8 Ḟᦆ࣐࢘ࢫࢆ⏝࠸ࡓከⓎᛶ◳໬⑕ࡢ⑌ᝈࣔࢹࣝ㸦EAE㸧ࢆస〇ࡋࡓ࡜ࡇࢁࠊ㔝⏕ᆺࡢ EAE ࣐࢘ࢫࡼࡾࡶ࣑ࢡࣟࢢࣜ࢔ࡢάᛶ໬ࡸቑṪࡀᢚไࡉࢀࠊど⚄⤒⅖࠾ࡼࡧ⬨㧊⅖ࡀ㍍⑕໬ࡋࡓࠋࡉࡽ࡟ DOCK8 Ḟᦆ࣐࢘ࢫࡢど⚄⤒᣸⁛ࣔࢹ࡛ࣝࡣࠊ⥙⭷⚄⤒⠇⣽⬊ࢆ㈎㣗ࡍࡿ࣑ࢡࣟࢢࣜ࢔⣽⬊ᩘࡀῶᑡࡋࡓࠋ௨ୖ
࠿ࡽ DOCK8 ࡣ࣑ࢡࣟࢢࣜ࢔ࡢάᛶ໬ࢆಁ㐍ࡋ࡚ࠊ⚄⤒ኚᛶࢆቑᝏࡉࡏࡿྍ⬟ᛶࡀ♧ࡉࢀࡓ㸦Journal of Biological Chemistry, 2019㸧ࠋ

(3)

୰࡛࠶ࡿࠋ

ᅜෆእ䛾◊✲≧ἣ࣭ ➨㸲ᮇࣉࣟࢪ࢙ࢡࢺ࡟࠾࠸࡚ࡣࠊࡼࡾࣄࢺ࡟㏆࠸ᙧែⓗ≉ᚩ࡜どᶵ⬟ࢆྜࢃࡏᣢ
ṇᖖ║ᅽ⥳ෆ㞀ࣔࢹࣝື≀ࡢ☜❧ࡣୡ⏺ึࡢᡂᯝ࡛࠶ࡿࠋ㟋㛗㢮ࡘ㟋㛗㢮ࢆά⏝ࡋ࡚ࠊ㞴἞ᛶ║⑌ᝈ࡟ᑐࡍࡿ⚄⤒ಖㆤ࠾ࡼࡧど⚄⤒෌⏕◊✲ࢆࡉࢆ⏝࠸ࡓ⚄⤒ಖㆤࠊど⚄⤒෌⏕࡞࡝ࡢ║⛉◊✲ࡣࠊୡ⏺ⓗ࡟ࡶࡲࡔࡽ࡟ຍ㏿ࡉࡏࡿィ⏬࡛࠶ࡿࠋࡇࡢ┠ⓗࢆ㐩ᡂࡍࡿࡓࡵࠊୖ㏙ࡢ⮬↛Ⓨ⑕⥳ෆ㞀ಶయࡢヲ⣽࡞ゎᯒ࡟ຍ࠼࡚ࠊୡ⏺ึࡢ㑇ఏᏊᨵኚ⥳ෆ㞀࣐࣮ࣔࢭࢵࢺࡢసᡂࡀ㐍⾜࡯࡜ࢇ࡝⾜ࢃࢀ࡚࠸࡞࠸ࠋ

(2)

ㄽᩥᥖ㍕ㄅ䞉Ⓨ⾲Ꮫ఍ྡ➼࣭ Namekata et al. Journal of Biological Chemistry (in press)
࣭ Kimura et al. Neural Regeneration Research, 2020
࣭ 㔝࿅㝯ᙪࠊཎ⏣㧗ᖾ. ᪥ᮏࡢ║⛉, 2020
࣭ ཎ⏣㧗ᖾ. The Lung Perspective, 2020
࣭ Noro et al. Scientific Reports, 2019
࣭ Honda et al. Investigative Ophthalmology & Visual Science, 2019
࣭ Namekata et al. Journal of Biological Chemistry, 2019
࣭ Sano et al. Cell Death and Disease, 2019࣭ Harada et al. British Journal of Ophthalmology, 2019
࣭ Wiltrout et al. European Journal of Human Genetics, 2019
࣭ Akaiwa et al. Investigative Ophthalmology & Visual Science, 2018
࣭ Azuchi et al. Scientific Reports, 2018࣭ ཎ⏣㧗ᖾ. ⥳ෆ㞀἞⒪࡬ࡢ᪂ࡓ࡞࢔ࣉ࣮ࣟࢳ. ➨ 39 ᅇ ᪥ᮏ║⸆⌮Ꮫ఍, 2019.9.15. (INVITED)࣭ Honda et al. ARVO Annual Meeting, 2019.4.28., Vancouver, Canada࣭ Takayuki Harada. Spontaneous normal tension glaucoma in aged
marmosets. 8th World Glaucoma Congress (WGC 2019), 2019.3.30,
Melbourne, Australia(1)(2) ◊✲⪅ྡ
ཎ⏣㧗ᖾ
⾜᪉࿴ᙪ
㒌 ᬡ㯇
ᮌᮧᩔᏊ
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㔠 ⩏㐨㸦ᮾிឿᜨ఍་⛉኱Ꮫ║⛉㸧ᮏ⏣⣪㔛㸦㡰ኳᇽ኱Ꮫ║⛉㸧໭ᮧ⿱ኴ㸦༓ⴥ኱Ꮫ║⛉㸧Ύ⏣┤ᶞ㸦ᮾ໭኱Ꮫ║⛉㸧బᇣᘯᶞ㸦ᚨᓥ኱Ꮫ║⛉㸧
ཎ⏣▱ຍᏊ
⛅ᒣᝅ୍
ᏳᅵࡺࡾᏊ
㸦ᮾ㑥኱Ꮫ⌮Ꮫ㒊㸧(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5 ᖺ㛫㸧

㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌◊✲ᮇ㛫䞉◊✲⪅ྡ➼㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ཎ⏣㧗ᖾ㸧㸦◊✲௦⾲⪅ྡ㸧◊㻌 㻌 ✲㻌 㻌 ෆ㻌 㻌 ᐜ⥙⭷࣭ど⚄⤒ኚᛶ⑌ᝈࡢ⑓ែゎ᫂࡜἞⒪ἲ㸭どぬ⑓ែࣉࣟࢪ࢙ࢡࢺ

◊✲ㄢ㢟ྡ㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾᴫせ(1) ᡂᯝࡢᴫせ᪥ᮏ࡟࠾ࡅࡿ୰㏵ኻ᫂ཎᅉࡢከࡃࡣ⥙⭷࠾ࡼࡧど⚄⤒ࡢኚᛶ⑌ᝈ ࣭ ⥳ෆ㞀ࡢཎᅉ࡜ࡋ࡚㧗║ᅽ௨እ࡟㑇ఏᏊ␗ᖖࡀ▱ࡽࢀ࡚࠸ࡿࡀࠊ඲య࡛ࡣ 10㸣௨ୗ࡛࠶ࡿࠋ≉࡟ᅜෆࡢ⥳ෆ㞀ࡢ⣙㸵๭ࢆ༨ࡵࡿṇᖖ║ᅽ⥳ෆ㞀㸦NTG㸧࡟࠾࠸࡚࡛࠶ࡿࠋ≉࡟Ḣ⡿ᆺࣛ࢖ࣇࢫࢱ࢖ࣝࡢᾐ㏱ࡸ㧗㱋໬♫఍ࢆ⫼ᬒ࡟
ࡣࠊᵝࠎ࡞඲㌟ⓗせᅉࡢ㛵୚ࡀ᝿ᐃࡉࢀࡿࠋᙜࣉࣟࢪ࢙ࢡࢺ࡛ࡣ NTG ࣔࢹࣝື≀ࠕ║ࡢᡂே⑓ࠖ࡜ࡶ࠸࠼ࡿ⥳ෆ㞀ࡸ⢾ᒀ⑓⥙⭷⑕࡞࡝ࡢᝈ⪅ᩘቑຍ㸦ࢢࣝࢱ࣑ࣥ㓟㍺㏦య࡛࠶ࡿ EAAC1 ࡲࡓࡣ GLAST Ḟᦆ࣐࢘ࢫ㸧ࡢゎᯒ࡞࡝࠿ࡽ
ࡀ኱ࡁ࡞ㄢ㢟࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ㧗㱋໬ࢆ㏄࠼ࡿ᪥ࠕຍ㱋࡟ࡼࡿࢢࣝࢱ࣑ࣥ㓟㍺㏦యࡢⓎ⌧㔞పୗЍࢢࣝࢱࢳ࢜ࣥࡢ⏘⏕పୗЍ㓟໬ᮏ♫఍඲యࡢ 42/ ྥୖ࡜ࠊ㒔Ẹࡢࢽ࣮ࢬ࡟ᗈࡃᛂ࠼ࡿࡓࡵ࡟ࠊ㞴἞ࢫࢺࣞࢫࡢஹ㐍ࠖ➼ࡀ⑓ែ࡟㛵୚ࡍࡿྍ⬟ᛶࢆ⪃៖ࡋ࡚࠸ࡿࠋ୍᪉ࠊ⠠≧ᯈࡢᏑᅾࡋ࡞࠸࣐࢘ࢫ࡛ࡣࠊ≉ᚩⓗ࡞ど㔝㞀ᐖࣃࢱ࣮ࣥࡢ෌⌧ࡣ୙ྍ⬟࡛࠶ࡿࡇ࡜࠿
ᛶ║⑌ᝈࣔࢹࣝࡢ㛤Ⓨࢆ㏻ࡋ࡚ࠊࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒࡜἞⒪ἲ㛤Ⓨࡽࠊᡃࠎࡣࡼࡾࣄࢺ࡟㏆࠸ࣔࢹࣝ࡜ࡋ࡚ࠊ⪁㱋࣐࣮ࣔࢭࢵࢺࡢ᳨ウࢆ⾜ࡗࡓࠋᡃࢆ┠ᣦࡍࠋ

୺࡞◊✲ᡂᯝ 

－ 34 －  ᡂᯝࡢᴫせ◊       ✲       ᡂ       ᯝ
 

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  㛫࣭  ◊✲  ⪅ྡ  ➼ 㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୰ᒣඃᏘ㸧㸦◊✲௦⾲⪅ྡ㸧◊  ✲  ෆ  ᐜ$/6➼⚄⤒㞴⑓⒪㣴⪅࡬ࡢ┳ㆤࢣ࢔࠾ࡼࡧ⒪㣴ᨭ᥼ࢩࢫࢸ࣒ࡢ㛤Ⓨ࣭ホ౯㸭㞴⑓ࢣ࢔┳ㆤࣉࣟࢪ࢙ࢡࢺ

◊✲ㄢ㢟ྡ

㸰㸮㸰㸮ᖺ㸱᭶㸱㸯᪥⌧ᅾ  ᴫせ  ◊✲ᮇ㛫ᖺ᭶㹼ᖺ᭶
࣭ពᛮఏ㐩ᨭ᥼ᢏ⾡࣭ᨭ᥼యไࡢᵓ⠏࣭Ẽ⟶ษ㛤ேᕤ࿧྾ᐇ᪋୰ࡢ$/6ᝈ⪅ࡢྜే⑕࣭㝶క⑕≧㸦1RQ࣭Ẽ㐨ί໬ཱྀ࣭⭍ࢣ࢔ᢏ⾡ࡢ☜❧
PRWRU PDQLIHVWDWLRQV㸧ࡢ⤒ᖺㄪᰝࢆ⥅⥆ࡍࡿ࡜࡜ࡶ࡟ࠊデ᩿᫬ 㸦ᖺ㛫㸧࣭┳ㆤࢣ࢔ᢏ⾡㛤Ⓨࡢᇶ┙࡜࡞ࡿᇶ♏࣭⮫ᗋ◊✲࠿ࡽẼ⟶ษ㛤᫬ࡲ࡛ࡢయ㔜ῶᑡࡢ⛬ᗘࡀ኱ࡁ࠸࡯࡝ࡑࡢᚋࡢ㐍  ◊✲⪅ྡ࣭┳ㆤ࣭௓ㆤ㐃ᦠ㉁ᣦᶆࡢ㛤Ⓨ࡜ᅾᏯ་⒪Ᏻ඲ࢩࢫࢸ࣒ᵓ
⾜ࡶ᪩࠸ࡇ࡜ࢆ♧ࡋࠊ⑓ึᮇࡢయ㔜ῶᑡࡀ$/6࡟≉␗ⓗ࡞ࠊ⚄୰ᒣඃᏘ㸦་Ꮫ◊㸧⠏⤒ኚᛶ࡜㛵㐃ࡋࡓ⌧㇟࡛࠶ࡿࡇ࡜ࢆ♧၀ࡋࡓࠋ
࣭$/6➼⒪㣴⪅ࡢࢣ࢔ࢩࢫࢸ࣒ ホ౯ ᣦᶆࡢ㛤Ⓨ࡜ホ౯࣭$/6ᝈ⪅౛ࡢ⯉ᅽ࡜⮫ᗋᣦᶆ࡜ࡢ㛵ಀࢆ᳨ウࡋࠊ⯉ᅽࡣࠊ ᑠ಴ᮁᏊ ་Ꮫ◊ ࣭㞴⑓ࢣ࢔┳ㆤࢹ࣮ࢱ࣮࣋ࢫ࡟ࡼࡿ◊✲ᡂᯝࡢᬑཬࠋ
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࣭6FLHQWLILF5HSRUW$P\RWURSKLF/DWHUDO6FOHURVLVDQG
࣭ᅾᏯ࡛ࡢ┳ㆤ⫋࣭௓ㆤ⫋ࡢ㐃ᦠᣦᶆ࡟ᇶ࡙ࡃ඲ᅜㄪᰝ࡟ࡼࡾࠊ ➟ཎᗣ௦㸦་Ꮫ◊㸧
)URQWRWHPSRUDO'HJHQHUDWLRQ-RXUQDORI1HXURORJ\  సᡂࡋࡓ㐃ᦠ࡟ࡼࡿࣜࢫࢡ⟶⌮ࣉࣟࢢ࣒ࣛࢆᇶ┙࡟ࠊࡉࡽ࡟⫋ ΎỈಇኵ ⚄⤒⑓㝔 ࣭᪥ᮏ⚄⤒Ꮫ఍✀ࡸᶵ㛵ࢆ㉸࠼ࡓᏳ඲⟶⌮ࢆ┠ᣦࡍࠕ་⒪ᶵ㛵ᆅᇦᨭ᥼ᶵ㛵 ᑠ᳃㝯ྖ ⚄⤒⑓㝔 ࣭᪥ᮏ⚄⤒἞⒪Ꮫ఍ࡢ㐃ᦠ࡟ࡼࡿࣜࢫࢡ⟶⌮ᣦᶆࠖࡢ㛤Ⓨ࡟╔ᡭࡋࡓࠋᅾᏯேᕤ࿧ ᕝ⏣᫂ᗈ ⚄⤒⑓㝔 ࣭᪥ᮏ࿧྾ࢣ࢔ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍
ᮌ⏣⪔ኴ ⚄⤒⑓㝔 ྾⟶⌮࢖ࣥࢩࢹࣥࢺ᝟ሗZHEࢩࢫࢸ࣒ࢆ౛᭦᪂ࡋࡓࠋ
࣭ᅾᏯ་⒪㐃ྜᏛ఍࣭ࠕ㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ࠖࡢㄪᰝ࡟࠾࠸࡚ࠊタ⨨⋡ࡣ๓ᖺ࡟ẚࡋ ᕝᮧబ࿴Ꮚ ⪷㞔ࢡࣜࢫࢺ࣭᪥ ᮏ 㞴 ⑓ ┳ ㆤ Ꮫ ఍ ࠊ ᪥ ᮏ 㞴 ⑓ ་ ⒪ ࢿ ࢵ ࢺ ࣡ ࣮ ࢡ Ꮫ ఍ ࠊୖ᪼ࡋࡓࠋタ⨨᭷↓࡜㞴⑓ಖ೺άື≧ἣ࡜ࢆẚ㍑ࡋࡓ⤖ᯝࠊ ࣇ࢓࣮኱Ꮫ㸧᪥ᮏᅾᏯࢣ࢔Ꮫ఍ࠊ᪥ᮏᅾᏯ┳ㆤᏛ఍ࠕᮏᗇ࡜ಖ೺ᡤ➼ಖ೺ᖌ࡜ࡢᐃᮇⓗ࡞㐃⤡఍࠶ࡾࠖࠕ㞴⑓஦ᴗᐇ᪋࠶ࡾࠖࡢ⮬἞య࡛༠㆟఍タ⨨⋡ࡀ㧗ࡃࠊ༠㆟఍タ⨨ࡢ᭷↓  ᅜෆእࡢ◊✲≧ἣ࡜㞴⑓ಖ೺άື࡜ࡢ㛵㐃ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
ཎᅉ✲᫂࡟㛵ࡍࡿ◊✲ሗ࿌ࡸ⮫ᗋ἞㦂ࡢ」ᩘྠ᫬ᐇ᪋࡞
࡝ࠊ἞⒪ἲ㛤Ⓨ࡟ྥࡅࡓྲྀࡾ⤌ࡳࡀ๓㐍ࡋ࡚࠾ࡾࠊ㐍⾜ᢚไ ࣭㞴⑓ἲ࡟ᇶ࡙ࡃࠊ࿧྾ჾᨭ᥼஦ᴗࡢᐇ⦼ሗ࿌᭩ࡢศᯒࢆ㐍ࡵࡿ࡜࡜ࡶ࡟ࠊᥦฟ㒔㐨ᗓ┴ࡢゼၥ┳ㆤࢫࢸ࣮ࢩࣙࣥ࡬ࡢ㉁ၥ⣬ㄪࡸணᚋࡢ㐍ᒎࡀᮇᚅ࡛ࡁࡿ㌿᥮ᮇࢆ㏄࠼ࡼ࠺࡜ࡋ࡚࠸ࡿࠋ
ᰝࢆ⾜࡞ࡗࡓࠋ஦ᴗ฼⏝᭷↓࡟ࡼࡿゼၥ┳ㆤᥦ౪ࡸ⑓≧࡟ࡘ࠸㞴⑓་⒪ἲࡢ᪋⾜㸦㸧ࡸ㞀ᐖ⪅ᕪูゎᾘἲ㸦㸧࡞࡚ࡢẚ㍑ࢆ⾜࠸ࠊ஦ᴗࡣࠊࡼࡾ㔜ᗘ࡞ᑐ㇟࡟฼⏝ࡉࢀࠊ㛗᫬㛫࡝ࠊ♫఍᝟ໃࡢ኱ࡁ࡞㌿᥮ᮇࡢ୰ࠊ᫬௦࡟༶ࡋࡓಖ೺࣭་⒪ゼၥ┳ㆤᥦ౪ࡢ୍ᡭẁ࡟࡞ࡾ࠺ࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭⚟♴ࡢ㐃ᦠ࡟ࡼࡿࢧ࣮ࣅࢫᥦ౪యไࡢ☜❧ࡀᚲせ࡛࠶ࡿࡀࠊ㞴⑓࡟࠾࠸࡚ࡇࢀࡽࢆ⤫ྜࡋࡓ◊✲άືࢆ⾜ࡗ࡚࠸ࡿ᪋タࡣࠊᙜᡤࢆ࠾࠸࡚௚࡟ࡣぢᙜࡓࡽ࡞࠸ࠋேᕤ࿧྾⒪ἲࡢᬑ   ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ୖグࡢ◊✲ࢆࠊ㒔❧⚄⤒⑓㝔࡜ࡢ㐃ᦠࡢࡶ࡜ࠊ㛗ᮇⓗᒎᮃ◊✲ཬ࣭㛗ᮇ໬࡟కࡗ࡚⏕ࡌࡓ᪂ࡓ࡞ၥ㢟ࡸᇶ♏⮫ᗋ◊✲ᡂᯝ࡟ࡼࡗ࡚᫂ࡽ࠿࡜࡞ࡗ࡚ࡁ࡚࠸ࡿㄢ㢟ࢆඞ᭹ࡍࡿࡓࡵࡢ┳ㆤࢣ ࡜ࡋ࡚ࠊ$/6ࢭࣥࢱ࣮࡟࠾ࡅࡿࢥ࣮࣍ࢺ㏣㊧ㄪᰝ࡟ࡘ࡞ࡆࠊ㞴⑓࢔ᢏ⾡ࡢ㛤Ⓨࡀồࡵࡽࢀࠊ$/6ࢆࣔࢹࣝ࡟㞴⑓඲⯡࡟ᛂ⏝ࡋ ┳ㆤࣞࢪࢫࢺࣜࡢᵓ⠏ࢆ┠ᣦࡍ࡜࡜ࡶ࡟ࠊ㞴⑓ᝈ⪅඲⯡࡟࠾ࡅࡿ⏕ά㞀ᐖᣦᶆࡢ㛤Ⓨࢆ┠ᣦࡋࠊ♫఍㑏ඖ࡟ᐤ୚ࡍࡿࠋ
࡚࠸ࡃࡇ࡜ࡀồࡵࡽࢀ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ 

－ 35 －

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⢾ᒀ⑓ᛶᮎᲈ⚄⤒㞀ᐖࡢ⣽⬊࣭ಶయ࡛ࣞ࣋ࣝࡢゎᯒࢆ㐍ࡵࠊᡂᅉ࡟ᇶ࡙ࡃ἞⒪⸆ࡢ㛤Ⓨ࡟㈉⊩ࡍࡿࠋ㔝⏕ᆺ࠾ࡼࡧኚᛶᛶㄆ
▱⑕ࣔࢹࣝࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ㧗⢾㉁㣗ࡲࡓࡣ㧗⬡⫫㣗࡛㣫⫱ࡋࠊ⚄⤒ኚᛶࠊ⢾໬≀⵳✚ࠊ㓟໬ࢫࢺࣞࢫஹ㐍࡬ࡢᙳ㡪ࢆ᳨ウࡍࡿࠋࡲࡓ௚᪋タ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ㑇ఏᛶࠊ⸆๣ᛶࠊච␿
௓ᅾᛶᮎᲈ⚄⤒㞀ᐖࡢ⑓ែゎ᫂࡟㈉⊩ࡍࡿࠋᅜෆእࡢ◊✲≧ἣ⢾ᒀ⑓࡟క࠺ᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢᇶ♏◊✲࡟ᚑ஦ࡍࡿ
◊✲⪅࣭་ᖌࡀᑡ࡞࠸≧ἣࡢ୰࡛ࠊᙜࣉࣟࢪ࢙ࢡࢺࡣ୺せ◊✲ᣐⅬࡢ୍ࡘ࡜ࡋ࡚ᮇᚅࡉࢀ࡚࠸ࡿࠋᘯ๓኱ࠊឿᜨ་኱ࠊឡ
▱Ꮫ㝔኱㸦ᮎᲈ⚄⤒㞀ᐖ㸧ࠊ㜰኱ࠊⰪᾆᕤ኱㸦ㄆ▱⑕㸧➼࡜ࡢඹྠ◊✲ࢆ᥎㐍ࡋࠊࡑࡢᡂᯝࢆ㒔ᨻ࡟㑏ඖࡍࡿ࡜࡜ࡶ࡟ᅜ
ෆእ࡟ྥࡅ࡚ᗈࡃⓎಙࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ J Neurochem (2015, 2018)
࣭ Histochem Cell Biol (2015, 2018, 2020, 2020)
࣭ Neurosci Res (2015, 2019)
࣭ Eur J Neurosci (2016)
࣭ Human Mol Genet (2018)
࣭ PLoS ONE (2018, 2019)࣭ Nat Commun (2019)
࣭ Brain (2019)࣭ J Diabetes Investig (2019, 2019)࣭ ᪥ᮏ⢾ᒀ⑓Ꮫ఍ࠊ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍ࠊ᪥ᮏ⚄⤒Ꮫ఍ࠊ᪥ᮏᮎᲈ⚄⤒Ꮫ఍࣭ ᪥ᮏ⏕⌮Ꮫ఍ࠊ᪥ᮏ⑓ែ⏕⌮Ꮫ఍࣭ ᪥ᮏ⏕໬Ꮫ఍ࠊ᪥ᮏศᏊ⏕≀Ꮫ఍࣭ ᪥ᮏㄆ▱⑕Ꮫ఍࣭ Ḣᕞ⢾ᒀ⑓Ꮫ఍࣭⚄⤒㞀ᐖศ⛉఍ (Neurodiab)



(3)

(2)

(2)

ᡂᯝࡢᴫせ
࣭ ࢔ࣝࢻ࣮ࢫ㑏ඖ㓝⣲㑇ఏᏊḞᦆ࣐࢘ࢫࡼࡾᶞ❧ࡋࡓࢩࣗ࣡ࣥ⣽⬊ᰴIKARS1ࡣࠊ࣏࣮ࣜ࢜ࣝ௦ㅰ⣔㓝⣲ࡢmRNA࣭⺮ⓑⓎ⌧పୗ࡜࢔ࣝࢹࣄࢻ௦ㅰ㓝⣲⩌ࡢmRNAⓎ⌧ୖ᪼ࢆ࿊ࡋࡓ (JNeurochem 2018; Neural Reg Res 2018)ࠋ
࣭ ᭱⤊⢾໬⏘≀ (AGEs)๓㥑≀㉁ࡢ୰࡛ࠊࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄ
ࢻࡀᇵ㣴ឤぬࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊࡟ᑐࡋ࡚᭱ࡶᙉ࠸ẘᛶࢆ♧ࡋࠊࢽ࣮ࣗࣟࣥṚࡢㄏᑟ࡟JNK࠾ࡼࡧp38 MAPKࢩࢢࢼࣝࡢ㛵୚ࡀ♧၀ࡉࢀࡓ (Histochem Cell Biol 2020)ࠋ
࣭ ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊ᰴࢆ㧗ࢢࣝࢥ࣮ࢫ࣭እᅉᛶࣆࣝࣅ
ࣥ㓟Ḟኻ⎔ቃୗ࡟ᭀ㟢ࡍࡿ࡜ࠊゎ⢾⣔࣭ࢡ࢚ࣥ㓟ᅇ㊰ࢆ௓ࡋࡓ࢚ࢿࣝࢠ࣮௦ㅰࡀⴭࡋࡃᢚไࡉࢀࡿ࡜࡜ࡶ࡟ࠊᑠ⬊యࢫࢺࣞࢫ࣭㓟໬ࢫࢺࣞࢫࡀㄏᑟࡉࢀࠊ▷᫬㛫࡛㢧ⴭ࡞⣽⬊Ṛࡀぢࡽࢀࡓ 㸦ඵᏊ, 2017᪥ᮏ⑓ែ⏕⌮Ꮫ఍◊✲ዡບ㈹ཷ㈹)ࠋ
࣭ exendin-4࡟ࡼࡿ㍈⣴ఙ㛗ಁ㐍࣭⚄⤒⣽⬊⏕Ꮡ⥔ᣢస⏝࡟ࠊPI3
kinase⤒㊰ࢆ௓ࡋࡓ෌⏕㜼ᐖᅉᏊRhoAάᛶࡢᢚไࡀ㛵୚ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (Histochem Cell Biol 2015)ࠋ
࣭ ࢔࣑ࣟ࢖ࢻ࣏ࣜࢽ࣮ࣗࣟࣃࢳ࣮ࡸ࢔࣑࢜ࢲࣟࣥ࡟ࡼࡿ⬺㧊ᛶࢽ࣮ࣗࣟࣃࢳ࣮ࡢᇵ㣴⣔ࣔࢹࣝࢆ☜❧ࡋࡓ (J Neurochem 2015;
Eur J Neurosci 2016)ࠋ
࣭ ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไࢱࣥࣃࢡ㉁RubiconࡢⓎ⌧ᢚไࡣࠊ⚄⤒ኚᛶ ⑌ ᝈ ࣔ ࢹ ࣝ ࢩ ࣙ ࢘ ࢪ ࣙ ࢘ ࣂ ࢚ ࡢ ⑕ ≧ ࢆ ᨵ ၿ ࡋ ࡓ (NatCommun 2019;኱ሙ, 2018᪥ᮏ⑓ែ⏕⌮Ꮫ఍◊✲ዡບ㈹ཷ㈹) ࠋ
(1)

E

ᴫせ
࣭ ࣏࣮ࣜ࢜ࣝ௦ㅰஹ㐍ࠊ⢾໬ࠊ㓟໬ࢫࢺࣞࢫ➼ࢆ௓ࡋࡓ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢⓎ⑕ᶵᵓゎ᫂
࣭ */3íཷᐜయసື⸆exendin-4ࡢ⚄⤒ಖㆤస⏝ࡢᶵᵓゎ࣭᫂ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓࠊ⢾ᒀ⑓࡟ࡼࡿ⚄⤒ኚᛶᶵᵓゎ࣭᫂ 㛵㐃ࡍࡿᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢ⑓ែゎ᫂

(1)

A

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2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

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－ 37 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧1.

ṇ஭ஂ㞝 Positive and negative regulation of DNA replication through G-quadruplexes. ⇃ᮏ኱Ꮫ࢚ࣜࢰࣥࣛ࣎◊✲఍㸭࣮ࣜࢹ࢕ࣥࢢࣉࣟࢢ࣒ࣛ㸸HIGO ᭱ඛ➃◊✲ࢭ࣑ࢼ࣮ 2020.2.5⇃ᮏ኱ᏛⓎ⏕་Ꮫ◊✲ᡤ㸪⇃ᮏ┴2.

Hisao Masai "Positive and negative regulation of DNA replication through G-quadruplexes.” IEOS
c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita' degli Studi di Napoli
Federico II , 2019.12.9, Naples, Italy

3.

Hisao Masai Biochemical and Biophysical Research Communications Editorial Board meeting,2019.12.6㹼12.7, Naples, Italy4.

ṇ஭ஂ㞝ࠊຍ⣡㇏ࠊ⏣୰༟ࠊྜྷἑ┤Ꮚࠊఀ⸨ࡉࡺࡾࠊ᳃ᒣ㈼἞ࠊຍ⸨ᏹᖾࠊ஭ཱྀᬛᘯࠊᯇᮏ
Ύ἞ࠊZhiying Youࠊ῝ὠ⌮஀ࠊむṇ┤Ꮚࠊ㮛᭸Ꮚࠊᑠᯘ㥴௓ࠊ᳿ᇶ㥴ࠊᇼ࠿ࡾࢇࠊ㧗ἑెⰾࠊᐩᶔ⫱Ꮚࠊୖ㔝຾ࠊ㛗⃝࿴ኵࠊYue Ma DNA 」〇ࡢṇ࡜㈇ࡢไᚚ࡟㛵ࢃࡿࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 201912.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

5.

⏣୰༟ࠊ㛵⏤⨾㤶ࠊ㮛᭸Ꮚࠊす⸨Ὀᫀࠊṇ஭ஂ㞝 ኱⭠⳦ࡢ multi-replicon ᵝᘧ㛤ጞ࡟ᚲせ࡜ࡉࢀࡿࢤࣀ࣒㓄ิ ➨ 42 ᅇ ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍࣭࣮࣡ࢡࢩࣙࢵࣉࠗ⏕≀࡟࠾ࡅࡿ㠀඾
ᆺⓗ DNA 」〇ࡢඹ㏻ᛶ࡜ከᵝᛶ ࠘ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ6.

ṇ஭ஂ㞝ࠊຍ⣡㇏ࠊ⏣୰༟ࠊఀ⸨ࡉࡺࡾࠊ῝ὠ⌮஀ࠊ᳃ᒣ㈼἞ࠊ㮛᭸Ꮚࠊむṇ┤Ꮚࠊྜྷἑ┤Ꮚࠊ஭ཱྀᬛᘯࠊຍ⸨ᏹᖾ ᪂ࡋ࠸ࢤࣀ࣒ࢩࢢࢼࢳ࣮ࣕ࡜ࡋ࡚ࡢ RNA-DNA ࣁ࢖ࣈࣜࢵࢻ
࡜ࢢ࢔ࢽࣥ㸲㔜㙐 ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍࣭ࢩ࣏ࣥࢪ࣒࢘ࠗ᪂ࡋ࠸ࢤࣀ࣒ࡢጼ࡜ࡑࡢ
⥔ᣢᶵᵓࡢࣇࣞ࢟ࢩࣅࣜࢸ࢕࠘ 2019.9.18㹼9.20 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷࡑࡢ௚ 㸦ィ 18 ௳㸧⮬⏤ᥖ㍕
1.

*ṇ஭ஂ㞝 Differential roles of Cdc7-Claspin in regulation of DNA replication in cancer and moncancer cells 㑇ఏ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ 2020.3.4㹼3.5 KKR ࣍ࢸࣝ⇕ᾏ㸪㟼ᒸ┴⇕ᾏᕷ

2.

*ṇ஭ஂ㞝 ࢢ࢔ࢽࣥ㸲㔜㙐 DNA ࡟ࡼࡿ DNA 」〇ࡢไᚚ ➨ 37 ᅇᰁⰍయ࣮࣡ࢡࢩࣙࢵ
ࣉ࣭➨ 18 ᅇ᰾ࢲ࢖ࢼ࣑ࢡࢫ◊✲఍ 2019.12.22㹼12.24 ᪂₲┴᪂Ⓨ⏣ᕷ

3.

*ṇ஭ஂ㞝 DNA 」〇ࡢṇ࡜㈇ࡢไᚚ࡟㛵ࢃࡿࢢ࢔ࢽࣥ 4 㔜㙐ᵓ㐀 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.4 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

4.

Tomohiro Iguchi, Satoshi Yamazaki, Tomio Ono, Karin Hori, Shunsuke Kobayashi, and *Hisao MasaiRoles of Cdc7 and its activation subunit ASK(Dbf4) in immune cell proliferation and differentiation.
➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

5.

Zhiying You, Chi-Chun Yang, *Hisao Masai Roles of the intramoleular interaction of Claspin in
regulation of DNA replication. ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

6.

Yang, C.-C, Mayumi Shindo, *Hisao Masai ✀ࠎࡢ⏕యࢫࢺࣞࢫ཯ᛂ࡟࠾ࡅࡿ Claspin ࡢࢫࢺࣞࢫᛂ⟅࣓ࢹ࢕࢚࣮ࢱ࣮࡜ࡋ࡚ࡢᙺ๭ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼
12.6 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

7.

ᑠᯘ㥴௓ࠊ஭ཱྀᬛᘯࠊᇼ࠿ࡾࢇࠊᑠ㔝ᐩ⏨ࠊ୸ᒣ༓⛅ࠊᒣᓮ⪽ᚿࠊ*ṇ஭ஂ㞝 Cdc7 ࢟ࢼ࣮ࢮάᛶ໬ࢧࣈࣘࢽࢵࢺ Dbf4/ASK ࡢ⬻ࡢⓎ⏕࡟࠾ࡅࡿᙺ๭ࡢゎ᫂ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ－ 38 －

 ᇼ࠿ࡾࢇࠊᑠᯘ㥴௓ࠊᑠ㔝ᐩ⏨ࠊ୸ᒣ༓⛅ࠊ ṇ஭ஂ㞝 ⬻Ⓨ⏕࡟࠾ࡅࡿ &GF$6. ࢟ࢼ࣮ࢮ」ྜయࡢᙺ๭ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ 㮛᭸Ꮚࠊ⏣୰༟ࠊ ṇ஭ஂ㞝 ኱⭠⳦ᰁⰍయ࡟࠾ࡅࡿ 51$'1$ K\EULG ࡢࣉࣟࣇ࢓࢖ࣝ࡜
ࡑࡢ」〇࡟࠾ࡅࡿᶵ⬟ࡢゎᯒ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ ྜྷἑ┤Ꮚࠊ ṇ஭ஂ㞝 」〇ࢱ࢖࣑ࣥࢢไᚚᅉᏊ 5LI ࡢḞኻࡀㄏᑟࡍࡿ  ⣽⬊ᮇ⬇ᵝ⣽⬊ࡢ࢚ࣥࣁࣥࢧ࣮ᵓ㐀 ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
 &KL&KXQ<DQJࠊ +LVDR0DVDL &GFDFWLYDWHVUHSOLFDWLRQVWUHVVFKHFNSRLQWWKURXJKSKRVSKRW\ODWLQJ&.%'RI&ODVSLQ ➨  ᅇ '1$ 」〇࣭⤌᥮࠼࣭ಟ᚟࣮࣡ࢡࢩࣙࢵࣉ  ዉⰋ᫓᪥㔝ᅜ㝿ࣇ࢛࣮࣒ࣛ⏉㸪ዉⰋ┴ዉⰋᕷ 㮛᭸Ꮚࠊ⏣୰༟ࠊ ṇ஭ஂ㞝 ኱⭠⳦ᰁⰍయ࡟࠾ࡅࡿ 51$'1$K\EULG ࡢࣉࣟࣇ࢓࢖ࣝ࡜
➨஧ࡢ」〇⣔࡟࠾ࡅࡿᶵ⬟ࡢゎᯒ ➨  ᅇ '1$ 」〇࣭⤌᥮࠼࣭ಟ᚟࣮࣡ࢡࢩࣙࢵࣉ
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/DERUDWRU\1HZ<RUN86$ ᑠᯘ㥴௓ࠊ஭ཱྀᬛᘯࠊᇼ࠿ࡾࢇࠊᑠ㔝ᐩ⏨ࠊ୸ᒣ༓⛅ࠊᒣᓮ⪽ᚿࠊ ṇ஭ஂ㞝 &GF ࢟ࢼ࣮ࢮάᛶ໬ࢧࣈࣘࢽࢵࢺ $6.'EI ࡢ⬻ࡢⓎ⏕࣭ᶵ⬟࡟࠾ࡅࡿᙺ๭ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ ᇼ࠿ࡾࢇ &GF$6. ࢟ࢼ࣮ࢮ」ྜయࡢ⬻ࡢⓎ⏕࡟࠾ࡅࡿᙺ๭ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ 0DVDL+ࠊ.DQRK<ࠊ0DWVXPRWR6ࠊ)XNDWVX5ࠊ.RED\DVKL6ࠊ.DNXVKR1ࠊ6HNLJXFKL1ࠊ
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DQDO\VHV RI 5LI SURWHLQ DQG *TXDGUXSOH[HV RQ WKH ILVVLRQ \HDVW JHQRPH  WK ,QWHUQDWLRQDO)LVVLRQ<HDVW0HHWLQJ320%( 㹼 %DUFHORQD㸪6SDLQ,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧 ṇ஭ஂ㞝 ◊✲ᡤ⤂௓Ꮫⱁ኱Ꮫ㝃ᒓ㧗ᰯ  ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ṇ஭ஂ㞝 ◊✲ᡤ⤂௓ຍྂᕝᮾ㧗ᰯゼၥ  ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ṇ஭ஂ㞝 ࢤࣀ࣒ '1$ 」〇ไᚚࡢ࣓࢝ࢽࢬ࣒࠿ࡽ᫂ࡽ࠿࡟࡞ࡗ࡚ࡁࡓࢤࣀ࣒ᶵ⬟ไᚚࡢ－ 39 －

᪂ཎ⌮ࠊ࠾ࡼࡧ⑌ᝈゎ᫂ࠊ᪂ࡋ࠸἞⒪ᡓ␎࡬ࡢᛂ⏝ ࠾ⲔࡢỈዪᏊ኱Ꮫ⌮Ꮫ㒊⏕≀Ꮫ⛉⏕࿨⛉Ꮫ≉Ṧㅮ⩏ VI 201910.26ࠊ2019.11.17 ࠾ⲔࡢỈዪᏊ኱Ꮫ㸪ᮾி㒔ᩥி༊
4.

ṇ஭ஂ㞝 ◊✲⪅࡜ࡋ࡚ࡢே⏕㸸ࢤࣀ࣒」〇ࡢ◊✲ࢆ౛࡟ ᮾி㒔ᩍ⫱ጤဨ఍୺ദ⌮ᩘ◊✲ࣛ࣎ 2019.8.5 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ5.

ṇ஭ஂ㞝 ◊✲ࡢෆᐜ⤂௓࣭◊✲ᡤ᱌ෆ ᪥ᮏ኱Ꮫᩥ⌮Ꮫ㒊⏕࿨⛉Ꮫゼၥ 2019.7.24ࠊ
2020.1.22ࠊ2020.1.29 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ

6.

ṇ஭ஂ㞝 ࢤࣀ࣒」〇ࡢ࣓࢝ࢽࢬ࣒࠿ࡽࢤࣀ࣒ไᚚࡢ᪂ࡋ࠸ཎ⌮ࡢⓎぢࢆࡵࡊࡍ 2019
ᖺᗘ S ࢭ࣓ࢫࢱ࣮ᮾி኱Ꮫᩍ㣴Ꮫ㒊඲Ꮫయ㦂ࢮ࣑ࢼ࣮ࣝ 2019.7.7 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊7.

ṇ஭ஂ㞝 ▱ከᕷ❧▱ከ୰Ꮫᰯゼၥ 2019.5.31 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ8.

ṇ஭ஂ㞝ࠊྜྷἑ┤Ꮚࠊ஭ཱྀᬛᘯ ࢤࣀ࣒ DNA 」〇ไᚚࡢ࣓࢝ࢽࢬ࣒࠿ࡽ᫂ࡽ࠿࡟࡞ࡗ࡚
ࡁࡓࢤࣀ࣒ᶵ⬟ไᚚࡢ᪂ཎ⌮ࠊ࠾ࡼࡧ⑌ᝈゎ᫂ࠊ᪂ࡋ࠸἞⒪ᡓ␎࡬ࡢᛂ⏝ ᮾி⌮⛉኱Ꮫ⏕≀⛉Ꮫ≉ูㅮ⩏ 3 2019.5.20ࠊ2019.5.27 ᮾி⌮⛉኱Ꮫ᯽࢟ࣕࣥࣃࢫ

9.

ṇ஭ஂ㞝 DNA ࡢᙧࡀไᚚࡍࡿࢤࣀ࣒ᶵ⬟࡜⑌ᝈ㸦Novel genome information determined by
the shape of DNA and diseases caused by its aberration㸧2019 ᖺᗘᮾி኱Ꮫ኱Ꮫ㝔 ᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉ ࣓ࢹ࢕࢝ࣝ᝟ሗ⏕࿨ᑓᨷㅮ⩏ࠕⓎᒎㅮ⩏ IVࠖ2019.5.17 ᮾ኱་⛉◊10. ṇ஭ஂ㞝 ◊✲ᡤ⤂௓ᮾிࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮ᑓ㛛Ꮫᰯゼၥ 2019.5.8 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ
11. ṇ஭ஂ㞝DNA 」〇ࡢศᏊ⏕≀Ꮫࠗࢤࣀ࣒ DNA 」〇ไᚚࡢ࣓࢝ࢽࢬ࣒࠿ࡽ᫂ࡽ࠿࡟࡞

ࡗ࡚ࡁࡓࢤࣀ࣒ᶵ⬟ไᚚࡢ᪂ཎ⌮ࠊ࠾ࡼࡧࡑࡢ⑌ᝈゎ࣭᫂᪂ࡋ࠸἞⒪ᡓ␎࡬ࡢᛂ⏝࠘ 2019ᖺᗘᮾி኱Ꮫ኱Ꮫ㝔 ᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉࣓ࢹ࢕࢝ࣝ᝟ሗ⏕࿨ᑓᨷㅮ⩏࣭ᇶ♏ㅮ⩏ II
2019.4.25 ᮾ኱་⛉◊IV. ≉グ஦㡯
ṇ஭ஂ㞝
࠙බ⫋Ṕࠚ
1.

⮬ 2017 ᖺ 4 ᭶⮳⌧ᅾ ᒣ⏣⛉Ꮫ᣺⯆㈈ᅋ㑅⪃ጤဨ

2.

⮬ 2017 ᖺ 1 ᭶⮳⌧ᅾ ᪥ᮏศᏊ⏕≀Ꮫ఍ ⌮஦

3.

⮬ 2010 ᖺ 4 ᭶⮳⌧ᅾ ᪥ᮏᏛ⾡఍㆟ 㐃ᦠ఍ဨ4.

⮬ 2006 ᖺ 4 ᭶⮳⌧ᅾ ᪥ᮏ⏕໬Ꮫ఍ ホ㆟ဨ

5.

⮬ 2010 ᖺ 7 ᭶⮳⌧ᅾ ᩥ㒊⛉Ꮫ┬⛉Ꮫᢏ⾡ᨻ⟇◊✲ᡤ•⛉Ꮫᢏ⾡ືྥ◊✲ࢭࣥࢱ࣮࣭⛉Ꮫᢏ⾡ᑓ㛛ㄪᰝဨ

6.

BMB2007 ࡞࡝ ࣉࣟࢢ࣒ࣛጤဨࠊᩥ㒊⛉Ꮫ┬ࠊᏛ⾡᣺⯆఍࡞࡝ ᑓ㛛ጤဨ࠙㞧ㄅ⦅㞟ࠚ
1.

2009 ᖺ 4 ᭶⮳⌧ᅾ Associate Editor, Genes to Cells (2009~Present)

2.

2006 ᖺ 4 ᭶⮳⌧ᅾ Associate Editor, Journal of Biochemistry (Tokyo) (2006~Present)

3.

2000 ᖺ 3 ᭶⮳⌧ᅾ Editor, Frontiers in Bioscience (1995-prdesent)

4.

2011 ᖺ⮳⌧ᅾ Faculty Opinions (Faculty 1000) member (2011~Present)5.

2013 ᖺ⮳⌧ᅾ Editor, Biochemical and Biophysical Research Communications (2013~Present)

࠙ᩍ⫱ࠚ
1.

㐃ᦠᩍဨ㸸ᮾி኱Ꮫ኱Ꮫ㝔ࠊᮾி⌮⛉኱Ꮫࠊ᪥ᮏ኱ᏛࠊᚚⲔࣀỈ኱Ꮫࠊ໭㔛኱Ꮫ－ 40 －

ࣉࣟࢪ࢙ࢡࢺྡ

့ங㢮㑇ఏࣉࣟࢪ࢙ࢡࢺ

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 <DVXGD 63 6HNL< 6X]XNL 6 2KVKLED< +RX ; 0DWVXRND .:DGD . 6KLWDUD + 0L\DVDND<.LNNDZD<F$!*JHQRPHHGLWLQJRIDCdh23ahlDOOHOHGHOD\VDJHUHODWHGKHDULQJ/RVVDQG
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

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

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 ࢩ࣑ࢵࢡ࣮࣍ࣝࢹ࢕ࣥࢢࢫ㸪ᮾி㒔 ྜྷᕝḠு 㡰㏫㑇ఏᏛ࡟ᇶ࡙ࡃ࣐࢘ࢫຍ㱋ᛶ㞴⫈Ⓨ⑕ཎᅉ㑇ఏᏊࡢྠᐃ ᪂₲኱Ꮫ⚄⤒ゎ๗Ꮫࢭ࣑ࢼ࣮  ᪂₲኱Ꮫ㸪᪂₲┴᪂₲ᕷࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ ౳㞷ྵࠊ㛵ඃኴࠊᏳ⏣ಇᖹࠊᯇᒸ㑥ᯞࠊྜྷᕝḠு ࣐࢘ࢫࡢ $%5 ࠾ࡼࡧ '32$( グ㘓᫬࡟⏝࠸ࡿ୕✀ΰྜ㯞㓉⸆ࡢホ౯ ➨  ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍Ꮫ⾡ㅮ₇఍  ࣍ࢸ࣓ࣝࢺ࣏ࣟࣜࢱࣥᒣᙧ㸪ᒣᙧ┴ᒣᙧᕷ ྜྷᕝḠுࠊ㛵ඃኴࠊ౳㞷ྵࠊᯇᒸ㑥ᯞࠊᏳ⏣ಇᖹ Lrrc30 㧗Ⓨ⌧࡟ࡼࡿ࣐࢘ࢫຍ㱋ᛶ㞴⫈
ࡢⓎ⑕ᢚไຠᯝ ➨  ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍Ꮫ⾡ㅮ₇఍  ࣍ࢸ࣓ࣝࢺ࣏ࣟࣜ
ࢱࣥᒣᙧ㸪ᒣᙧ┴ᒣᙧᕷ Ᏻ⏣ಇᖹࠊ㛵ඃኴࠊᯇᒸ㑥ᯞࠊྜྷᕝḠு %$/%F ள⣔⤫ࢆ⏝࠸ࡓ᪂つ㞴⫈㑇ఏᏊࡢ᥈⣴➨  ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍Ꮫ⾡ㅮ₇఍  ࣍ࢸ࣓ࣝࢺ࣏ࣟࣜࢱࣥᒣᙧ㸪ᒣᙧ┴ᒣᙧᕷ－ 41 －

4.

㛵ඃኴࠊタᴦᾈᚿࠊྜྷᕝḠு 3 ṧᇶᤄධ࣑࢜ࢩࣥϭࡢ⼗∵᭷ẟ⣽⬊࡟࠾ࡅࡿ≉ᚩⓗ࡞ᙺ๭ ➨ 32 ᅇࣔࣟࢩࢾࢫ◊✲఍ 2019.6.28 ࣍ࢸ࣓ࣝ࢖ࣉࣝ࢖ࣥᖥᙇ㸪༓ⴥ┴༓ⴥᕷ

5.

࿴⏣೺ኴࠊ኱ஂಖဏࠊ᐀ᙧ᫓ⰼࠊෆᒣ༤඘ࠊྜྷᕝḠு NAK ࣛࢵࢺࡢ║⌫Ⓨ⏕␗ᖖ࡟㛵㐃ࡍࡿ㑇ఏᏊኚ␗ ➨ 32 ᅇࣔࣟࢩࢾࢫ◊✲఍ 2019.6.27 ࣍ࢸ࣓ࣝ࢖ࣉࣝ࢖ࣥᖥᙇ㸪༓ⴥ
┴༓ⴥᕷ

6.

ᯇᒸ㑥ᯞࠊ࿴⏣೺ኴࠊᐑᆏຬ㍤ࠊᏳ⏣ಇᖹࠊ㛵ඃኴࠊす⸨Ὀᫀࠊタᴦᾈᚿࠊከᒇ㛗἞ࠊྜྷᕝḠு ෆ⪥እ᭷ẟ⣽⬊ࡢ◚ቯ࡟ࡼࡿ㑇ఏᏊⓎ⌧ኚືࡢゎᯒ ➨ 66 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2019.5.16 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

7.

࿴⏣೺ኴࠊྂᒇ⸅ᐇࠊ⚄Ọᓧᘺࠊᮧᒣࣜࢼࢥࠊ᳜ᮧᐇᏘࠊྜྷᕝḠு NAK/Nokh ࣛࢵࢺࡢᑠ║⌫⑕࡟㛵୚ࡍࡿ」ᩘࡢ㑇ఏᏊኚ␗ ➨ 66 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2019.5.15 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

8.

㛵ඃኴࠊᏳ⏣ಇᖹࠊ㕥ᮌἋ⌮ࠊ኱ⰪὈᘯࠊ౳㞷ྵࠊᯇᒸ㑥ᯞࠊ࿴⏣೺ኴࠊタᴦᾈᚿࠊᐑᆏ
ຬ㍤ࠊྜྷᕝḠு ࢝ࢻ࣊ࣜࣥ 23 ࡢ c.753A>G ࢤࣀ࣒⦅㞟ࡣ C57BL6/J ࣐࢘ࢫࡢຍ㱋ᛶ㞴⫈Ⓨ⑕࡜⼗∵᭷ẟ⣽⬊ࡢ⦅ᡂࢆ㐜ᘏࡉࡏࡿ ➨ 66 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2019.5.15 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯࡞ࡋ－ 42 －

ࣉࣟࢪ࢙ࢡࢺྡ

ឤᰁไᚚࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 8 ௳㸧
1.

Yasuhiro Sakai, Andri Rezano, Seiji Okada, Takahiro Ohtsuki, Yoshiaki Kawashima, Tetsuya
Tsukamoto, Motoshi Suzuki, Michinori Kohara, Motohiro Takeya, Nobuo Sakaguchi, Kazuhiko
Kuwahara *. A Novel Cytologic Model of B-cell/macrophage Biphenotypic Hodgkin Lymphoma in
Ganp Gene-Transgenic Mice. Cancers 2020 Jan 14;12(1).

2.

Hee Sun Kim, Youngsu You, Jae Gon Mun, Changdev G. Gadhe, Hee Jo Moon, Jae Sung Lee, Ae
Nim Pae, Michinori Kohara, Gyochang Keumd, Byeong Moon Kim,

Sung Key Jang.

Structure-

activity relationships of fluorene compounds inhibiting HCV variants. Antiviral Res. 2019 Dec
17:104678.
3.

Sanada T, Yamamoto N, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Miyazaki T, Takano
JI, Shiogama Y, Yasutomi Y, Goh Y, Yoshida O, Hiasa Y, *Kohara M. Intranasal vaccination with
HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody,anti-HBs IgA, and IFNG response. Biochem Biophys Res Commun. 2019 Nov 26;520(1):86-92.

4.

Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Yamane D, Takano JI,
Shiogama Y, Yasutomi Y, Ikeo K, Gojobori T, Mizokami M, *Kohara M. Construction of complete
Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing.
Sci Rep. 2019 Aug 26;9(1):12372.

5.

*Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi
I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi
T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK,
Lemon SM. Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistanceto multiple RNA viruses. Nat Microbiol. 2019 Jul;4(7):1096-1104.

6.

Feng H, Sander AL, Moreira-Soto A, Yamane D, Drexler JF, *Lemon SM. Hepatovirus 3ABC
proteases and evolution of mitochondrial antiviral signaling protein (MAVS). J Hepatol. 2019
Jul;71(1):25-34.

7.

*Hishiki T, Kato F, Nio Y, Watanabe S, Wen Tan NW, Yamane D, Miyazaki Y, Lin CC, Suzuki R,
Tajima S, Lim CK, Saijo M, Hijikata M, Vasudevan SG, Takasaki T. Stearoyl-CoA desaturase-1 isrequired for flavivirus RNA replication. Antiviral Res. 2019 May;165:42-46.

8.

Kitab B, Satoh M, Ohmori Y, Munakata T, Sudoh M, Kohara M, *Tsukiyama-Kohara K. Ribonucleotide
reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1dependent proteasomal degradation. J Biol Chem. 2019 Apr 12;294(15):5759-5773.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

－ 43 －

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Lemon, Iris Antes, Christian M. Lange, Christoph Welsch THE EVOLUTIONARY SPACE OFHCV UNDER DRUG PRESSURE IS RESTRICTED BY MAVS AASLD The Liver Meeting2019 2019.11.8㹼11.12 Boston, Massachusetts,U.S.A.
8.

*Tubasa MunakataࠊTakahiro SanadaࠊNaoki YamamotoࠊMichinori Kohara B ᆺ⫢⅖࢘࢖ࣝࢫ
ࡢ」〇ࢆಁ㐍ࡍࡿ࣐࢖ࢡࣟ RNA ࡣࣉࣞࢤࣀ࣒ RNA ࢆᶆⓗ࡜ࡍࡿ ➨ 67 ᅇ᪥ᮏ࢘࢖ࣝࢫ
Ꮫ఍Ꮫ⾡㞟఍ 2019.10.31 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔Ụᡞᕝ༊

9.

Tomoko Honda  Development and application of a highly sensitive NanoLuc-based
immunoprecipitation method for the detection of influenza virus HA antibodies ➨ 67 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2019.10.30 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔Ụᡞᕝ༊

10. *Takahiro SanadaࠊKyoko Tsukiyama-KoharaࠊTadasu Shin-IࠊNaoki YamamotoࠊMohammad
Enamul Hoque KayeshࠊMichinori Kohara Construction of genomic and transcriptomic databaseof the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection ➨ 67 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2019.10.29㹼10.31 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔Ụᡞᕝ༊
11. *Daisuke YamaneࠊAsuka Hirai-YukiࠊMichinori KoharaࠊStanly M.Lemon

RARRES3 mediates

interferon regulatory factor 1 -induced suppression of hepatitis A virus replication throughmodulation of m TOR activity ➨ 67 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2019.10.29㹼10.31 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔Ụᡞᕝ༊
12. Bouchra Kitab, Masaaki Satoh, Masayuki Sudoh, Tsubasa Munakata, Michinori Kohara, Kyoko
Tsukiyama-Kohara. RRM2 promotes RNA replication of hepatitis C virus by protecting NS5B
protein from hPLIC1 dependent proteasome degradation.

➨ 67 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍

2019.10.29㹼10.31 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔Ụᡞᕝ༊
13. Kyoko Tsukiyama-Kohara, Bouchra Kitab, Masaaki Satoh, Yusuke Ohmori, Tsubasa Munakata,
Masayuki Sudoh, Michinori Kohara.

Ribonucleotide Reductase M2 promotes RNA Replication of

Hepatitis C Virus by protecting NS5B Protein from hPLIC1-Dependent Proteasomal Degradation.
HCV2019 2019.10.5㹼10.8 COEX,Seoul,South Korea
14. Hee Sun Kim, Jae Gon Mun, Hee Jo Moon, Youngsu You, Jae Seung Lee, Michinori Kohara, Gyochang
Keum, Byeong Moon Kim, Sung Key Jang. Development of New NS5A Inhibitors Showing Strong
Anti viral Effects on all Genotypes of HCV. HCV2019 2019.10.5㹼10.8 COEX,Seoul,South Korea
15. Takahiro Ohtsuki, Yumiko Shiogama, Yuko Tokunaga, Kenzaburo Yamaji, Yasuhiro Yasutomi, Kyoko
Tsukiyama-Kohara, Michinori Kohara. Effective Therapeutic Vaccine for Hepatitis C Virus Infection
by Heterologous Antigen Immuno-therapy HCV2019 2019.10.5㹼10.8 COEX,Seoul,South Korea
16. *Tsubasa MunakataࠊTakahiro SanadaࠊNaoki YamamotoࠊMichinori Kohara Enhancement of
hepatitis B virus replication by a micro RNA targeting pregenomic RNA.

2019 International HBV

Meeting 2019.10.1㹼10.5 Melbourne㸪Australia
17. *Takahiro SanadaࠊKyoko Tsukiyama-KoharaࠊTadasu Shin-IࠊNaoki YamamotoࠊMohammad
Enamul Hoque KayeshࠊMichinori Kohara Construction of genomic and transcriptomic databaseof the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection 2019
International HBV Meeting : The Molecular Biology of Hepatitis B Viruses 2019.10.1㹼10.5
Melbourne Convention and Exhibition Centre㸪Melbourne Australia
18. Tsubasa Munakata, Takahiro Sanada, Naoki Yamamoto, Michinori Kohara. Enhancement of
hepatitis B virus replication by a microRNA targeting pregenomic RNA. 2019 international HBV
Meeting  2019.10.1㹼10.5 Melbourne Convention and Exhibition Centre㸪Melbourne Australia－ 45 －

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 ᗈᓥ኱Ꮫ⑓㝔ᗈோ఍㤋  㝵኱఍㆟ᐊ㸪ᗈᓥ┴ᗈᓥᕷ ᑠཎ㐨ἲࠊᒣᆅ㈼୕㑻ࠊᚨỌඃᏊࠊᑠཎᜤᏊࠊ኱⃝㝧௓ࠊᮌᮧබ๎ &%3㸭ȕFDWHQLQ ࢩࢢࢼࣝ㜼ᐖ๣ 35, ࡟ࡼࡿ 1$6+ ⫢⥺⥔⑕ᨵၿ ➨  ᅇᗈᓥ⫢⮚ࣉࣟࢪ࢙ࢡࢺ◊✲ࢭࣥࢱ࣮ࢩ࣏ࣥࢪ࣒࢘  ᗈᓥ኱Ꮫ⑓㝔ᗈோ఍㤋  㝵኱఍㆟ᐊ㸪ᗈᓥ┴ᗈᓥᕷ .HQ]DEXUR<DPDML<XNR7RNXQDJD<RVXNH2VDZD.LPLQRUL.LPXUD&KLVH7DWHQR<RXLFKL+LURVH
0LFKLQRUL.RKDUD  &%3ȕFDWHQLQVLJQDOLQJLQKLELWRULPSURYHG1$6+LQGXFHGOLYHUILEURVLVDQGOLYHUIDLOXUH7+(,17(51$7,21$//,9(5&21*5(6670 㹼  9LHQQD$XVWULD
 &KLVH 7DWHQR *R 6XJDKDUD .HLVKL .LVRK <XML ,VKLGD <DVXPL <RVKL]DQH 6X]XH )XUXNDZD0LFKLQRUL.RKDUD  'HYHORSPHQWRIKXPDQL]HGQRQDOFRKROLFVWHDWRKHSDWLWLVPRGHOXVLQJFKLPHULF
PLFHZLWKKLJKO\UHSRSXODWHGKXPDQL]HGOLYHUV7+(,17(51$7,21$//,9(5&21*5(6670
 㹼 9LHQQD$XVWULD
 0RKDPPDG (QDPXO +RTXH .D\HVK<XWDND$PDNR 1DRNL<DPDPRWR 6KXNR 0XUDNDPL 0DVD\D
6XJL\DPD <DVXKLWR 7DQDND 0DVDVKL 0L]RNDPL 0LFKLQRUL .RKDUD .\RNR 7VXNL\DPD.RKDUD'HYHORSPHQWRIDQLQYLYRGHOLYHU\V\VWHPIRU&5,635&DVPHGLDWHGWDUJHWLQJRIKHSDWLWLV%YLUXV
FFF'1$ WK-DSDQ7DLZDQ.RUHD+%95HVHDUFK6\PSRVLXP3URJUDP 㹼 ᅜ❧ឤᰁ⑕◊✲ᡤ㸪ᮾி㒔᪂ᐟ༊,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧࡞ࡋ,9 ≉グ஦㡯
࡞ࡋ
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－ 46 －

ࣉࣟࢪ࢙ࢡࢺྡ

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, ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ  ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
 'HYHORSPHQW RI DQ (QWHURYLUXV 9DFFLQH (IILFDF\7HVW 8VLQJ +XPDQ 6FDYHQJHU 5HFHSWRU %

7UDQVJHQLF0LFH,PXUD$6XGDND<7DNDVKLQR$7DPXUD..RED\DVKL.1DJDWD11LVKLPXUD+0L]XWD..RLNH6 J Virol.  H
 +HSDUDQVXOIDWHDWWDFKPHQWUHFHSWRULVDPDMRUVHOHFWLRQIDFWRUIRUDWWHQXDWHGHQWHURYLUXVPXWDQWVGXULQJ FHOO FXOWXUH DGDSWDWLRQ .RED\DVKL . 0L]XWD . .RLNH 6 PLoS Pathog    H
 1HZO\ HPHUJHG HQWHURYLUXV$ & VXEOLQHDJH PD\ EH PRUH YLUXOHQW WKDQ % LQ WKH
KDQGIRRWDQGPRXWKGLVHDVHRXWEUHDNLQQRUWKHUQ9LHWQDP&KX67.RED\DVKL.%L;,VKL]DNL
$7UDQ773KXQJ77%3KDP&771JX\HQ/97D7$.KX'7.$JRK03KDP$1.RLNH6
,FKLPXUD+Sci Rep  
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 &HOOXODUUHFHSWRUVIRUHQWHURYLUXV$.RED\DVKL..RLNH6J Biomed Sci.  㸦ᰝㄞ࠶ࡾ㸧 ᑠụᬛ ࣏ࣜ࢜࢘࢖ࣝࢫཷᐜయࠊ࢚ࣥࢸࣟ࢘࢖ࣝࢫ㸵㸯ཷᐜయࡢ⮫ᗋ࢘࢖ࣝࢫᏛ࡬ࡢᛂ⏝⮫ᗋ࡜࢘࢖ࣝࢫ    ᑠᯘ㒓௓ ↓⳦ᛶ㧊⭷⅖࡟㛵ࡍࡿ᭱㏆ࡢヰ㢟 ឤᰁ⑕   
,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧 ᑠụᬛ ࣏ࣜ࢜࢘࢖ࣝࡢࢺࣟࣆࢬ࣒ ➨  ᅇ࢘࢖ࣝࢫᏛ࢟ࣕࣥࣉ LQ ‫‮‬Ἑཎ 
ࢽ࣮࢙ࣗ࢘ࣝࢩࢸ࢕‫‮‬Ἑཎ㸪㟼ᒸ┴⇕ᾏᕷࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕
 .RED\DVKL . &KX 67 0L]XWD . 1LVKLPXUD + ,FKLPXUD + .RLNH 6 9LUXOHQFH DQDO\VLV RI
HQWHURYLUXV  LVRODWHG IURP KDQGIRRWDQGPRXWK GLVHDVH SDWLHQWV LQ -DSDQ DQG 9LHWQDP IRULGHQWLILFDWLRQ RI YLUXOHQFH GHWHUPLQDQW  7KH WK$QQXDO 0HHWLQJ RI7KH -DSDQHVH 6RFLHW\ IRU9LURORJ\  ࢱ࣮࣮࣡࣍ࣝ⯪ᶫ㸪ᮾி㒔Ụᡞᕝ༊,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧࡞ࡋ,9 ≉グ஦㡯࡞ࡋ－ 47 －

ࣉࣟࢪ࢙ࢡࢺྡ

ⰼ⢊⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

*Gotoh M, Kaminuma O, Nakaya A, Saeki M, Nishimura T, Kitamura N, Hiroi T and Okubo K(2020). Association of basophil-expressing genes with effectiveness of sublingual immunotherapy.
J Nippon Med Sch. 87(1): 49-52.

2.

*Tachibana M1, Watanabe N1, Koda Y1 (1: These authors are contributed equally.), Oya Y,
Kaminuma O, Katayama K, Fan Z, Sakurai F, Kawabata K, *Hiroi T and *Mizuguchi H (2020).
Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived
suppressor cells and NO production. Int Immunol. 32(3): 187-201.

3.

Kitamura N, Shindo M, Ohtsuka J, Nakamura A, Tanokura M, Hiroi T and *Kaminuma O (2020).
Identification of novel interacting regions involving calcineurin and nuclear factor of activated T
cells. FASEB J. 34(2) 3197-3208.

4.

*Hayashi K, Kaminuma O, Nishimura T, Saeki M, Matsuoka K, Hiroi T, Jutabha P, Iwata Y, Sugiura K,
Owada T, Kurasawa K, Okayasu I, Ouchi M, Fujita T, Kanai Y, Endou H and Anzai N (2020). LAT1-specificinhibitor is effective against T cell-mediated allergic skin inflammation. Allergy. 75(2): 463-467.

5.

Takaiwa, F, Yang L, Takagi H, Maruyama N, Wakasa Y, Ozawa K and *Hiroi T (2019).
Development of rice-seed-based oral allergy vaccines containing 2 hypoallergenic Japanese cedarpollen allergen derivatives for immunotherapy. J Agric Food Chem. 67(47): 13127-13138.

6.

*Kaminuma O1, Kitamura N1, Gotoh M1 (1: These authors are contributed equally.), Shindo M,
Watanabe N, Saeki M, Nishimura T, Mori A, Nemoto S, Tatsumi H, Okubo K and Hiroi T (2019).
Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of
sublingual immunotherapy. Allergol Int. 68S:S9-S10.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

*Saeki M, Nishimura T, Kitamura N, Hiroi T, Mori A and Kaminuma O (2019). Potential
Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness. Int
J Mol Sci. 20(12). pii: E2980. 㸦ᰝㄞ࠶ࡾ㸧

2.

⚄἟ಟࠊᚋ⸨✨ࠊ኱ஂಖබ⿱ࠊ୰㇂᫂ᘯࠊᘅ஭㝯ぶ (2019). ⤫ྜẚ㍑ゎᯒ࡛ぢ࠼࡚ࡁࡓ࢔
ࣞࣝࢤࣥච␿⒪ἲࡢస⏝࣓࢝ࢽࢬ࣒. ᪥ᮏ⸆⌮Ꮫ㞧ㄅ㸬154(1): 23-27.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋ

－ 48 －

ࡑࡢ௚ 㸦ィ 8 ௳㸧⮬⏤ᥖ㍕
1.

బ ఑ ┿ ᘪ  Th9 cells elicit bronchial hyperresponsiveness through eosinophil - independent
mechanisms. ➨ 93 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍. 2020.3.16㹼3.18. ⣬ୖ㛤ദ2.

Ỉཱྀ༤அࠊ୰㔝཭ᐶࠊす⏣ᾈᖹࠊఀ⸨ᬛᖹࠊ‪ᕝᮅ἞ࠊ⚄἟ಟࠊ໭ᮧ⣖Ꮚࠊ▼⏣㐩ஓࠊ㐨Ọᫀኴ㑻ࠊ⸭ᮏ㞞ᕭࠊ໭ᮧ჆❶ࠊṊ⏣᠇᫛ࠊ⚟஭⿱⾜. ⰼ⢊⑕Ⓨ⑕ࢩࢢࢼࣝᢚไ≀㉁ࣆࣟ
࣮࢞ࣟࣝࡢࢩࢢࢼࣝᢚไᶵᵓ. ➨ 22 ᅇ᪥ᮏࣄࢫࢱ࣑ࣥᏛ఍.

2020.2.2. ᗈᓥ኱Ꮫᗈோ఍

㤋㸪ᗈᓥ┴ᗈᓥᕷ
3.

ᮡཎㄔேࠊΏ㑔ఙᫀࠊ႐℩㧗ᗤࠊ▱ᛕ┤ྐࠊ୕ዲ㞝஧ࠊỌ஭ెᶞࠊᕸᕝ㈗༤ࠊᶓᕝ┤ேࠊ໭ᮧ⣖Ꮚࠊబ఑┿ᘪࠊす⸨Ὀᫀࠊᓥ⏣ᾈኴࠊᘅ஭㝯ぶ. ᕧ⣽⬊ᛶື⬦⅖ࡢ⑓ែゎ᫂࡟ྥࡅࡓ
㑇ఏᏊⓎ⌧ゎᯒ. ➨ 15 ᅇᮾி㒔⚟♴ಖ೺་⒪Ꮫ఍. 2019.12.20. ᮾி㒔♫఍⚟♴ಖ೺་⒪◊ಟࢭࣥࢱ࣮㸪ᮾி㒔ᩥி༊㸦ඃ⚽Ⓨ⾲㈹㸧

4.

Watanabe N, Kitamura N, Shitara H and Hiroi T. Genetic ablation of H2-Aa or H2-Ea gene in
BALB/c mice provides a new model to study functional differences of MHC-II subclass antigens.
➨ 48 ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍.  2019.12.11㹼13.࢔ࢡࢺࢩࢸ࢕὾ᯇ㸪㟼ᒸ┴὾ᯇᕷ

5.

బ఑┿ᘪࠊすᮧ཭ᯞࠊ⚄἟ಟࠊ㧗ᮌⱥ඾ࠊ᳃ᬗኵࠊ㧗ᒾᩥ㞝ࠊᘅ஭㝯ぶ. ⤒ཱྀච␿⒪ἲ⏝ࢹࣂ࢖ࢫ࡜ࡋ࡚ࡢ⡿⺮ⓑ㢛⢏ࡢ᭷⏝ᛶ. ࢔ࣞࣝࢠ࣮࣭ዲ㓟⌫◊✲఍ 2019. 2019.10.05. Ꮫ⾡⥲ྜࢭࣥࢱ࣮㸪ᮾி㒔༓௦⏣༊

6.

⚄἟ಟࠊᚋ⸨✨ࠊ୰㇂᫂ᘯࠊ໭ᮧ⣖Ꮚࠊすᮧ཭ᯞࠊబ఑┿ᘪࠊᘅ஭㝯ぶࠊ᳃ᬗኵࠊ኱ஂಖබ⿱ ࢔ࣞࣝࢤࣥච␿⒪ἲࡢຠᯝⓎ⌧࡟㛵ࢃࡿዲሷᇶ⌫࠾ࡼࡧ࣐ࢫࢺ⣽⬊㛵㐃࣓ࢹ࢕࢚࣮ࢱ࣮
࢔ࣞࣝࢠ࣮࣭ዲ㓟⌫◊✲఍ 2019. 2019.10.05. Ꮫ⾡⥲ྜࢭࣥࢱ࣮㸪ᮾி㒔༓௦⏣༊

7.

బ఑┿ᘪࠊすᮧ཭ᯞࠊ⚄἟ಟࠊ㧗ᮌⱥ඾ࠊ᳃ᬗኵࠊ㧗ᒾᩥ㞝ࠊᘅ஭㝯ぶ. ࢔ࣞࣝࢤࣥⓎ⌧⡿࡟ࡼࡿไᚚᛶ T ⣽⬊ࡢㄏᑟࢆ௓ࡉ࡞࠸ච␿ᐶᐜㄏᑟ. ➨ 68 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍Ꮫ
⾡኱఍ 2019.6.14. ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊

8.

Kaminuma O, Saeki M, Nishimura T, Kitamura N, Mori A and Hiroi T. Differential mechanismsof Th2- and Th9-mediated bronchial hyperresponsiveness in mice. ➨ 68 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ
఍Ꮫ⾡኱఍ 2019.6.14. ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

ᘅ஭㝯ぶ ᑠ⏣ཎ▷ᮇ኱Ꮫ࣭㠀ᖖ໅ㅮᖌ 㸦2019 ᖺ㸧

2.

ᘅ஭㝯ぶ ᪩✄⏣኱Ꮫᩍ⫱Ꮫ㒊⏕≀Ꮫ⛉࣭㠀ᖖ໅ㅮᖌ 㸦2006 ᖺ㹼⌧ᅾ㸧

3.

ᘅ஭㝯ぶ ᪥ᮏ኱ᏛᯇᡞṑᏛ㒊࣭㠀ᖖ໅ㅮᖌ 㸦1993 ᖺ㹼⌧ᅾ㸧

4.

బ఑┿ᘪ ⌮໬Ꮫ◊✲ᡤࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ ࣭ᐈဨ◊✲ဨ 㸦2013 ᖺ㹼⌧ᅾ㸧

－ 49 －

ࣉࣟࢪ࢙ࢡࢺྡ

ศᏊ་⒪ࣉࣟࢪ࢙ࢡࢺ

, ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ  ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
 *RWRK6DLWR 6 $EH 7 )XUXNDZD < 2GD 6 <RNRL 7 )LQHO 0 +DWDNH\DPD 0 )XNDPL 7
1DNDMLPD0&KDUDFWHUL]DWLRQRIKXPDQ8*7$H[SUHVVLRQXVLQJDSUHSDUHGVSHFLILFDQWLERG\DJDLQVW8*7$'UXJ0HWDE3KDUPDFRNLQHW
 .XWVXNDNH7)XUXNDZD<2QGR.*RWRK6)XNDPL7 1DNDMLPD04XDQWLWDWLYH$QDO\VLVRI
8'3*OXFXURQRV\OWUDQVIHUDVH 8JWD DQG 8JWE P51$ ([SUHVVLRQ LQ WKH 5DW /LYHU DQG 6PDOO,QWHVWLQH6H[DQG6WUDLQ'LIIHUHQFHV'UXJ0HWDE'LVSRV
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 Ლཎ┤ᶞࠊ Ⱚᓮኴ ་⸆ရࣔࢲࣜࢸ࢕ࡢ≉チᡓ␎࡜ᢏ⾡㛤Ⓨືྥࠊ➨  ❶ ࣌ࣉࢳࢻ་⸆
࡟㛵㐃ࡋࡓ௒ᚋࡢ≉チᡓ␎࡜㛤Ⓨືྥࠊ ⠇ ࣌ࣉࢳࢻࡢ⣽⬊⭷㏱㐣ᛶᢏ⾡ࡢ㛤Ⓨືྥࠊ㸦ᰴ㸧ᢏ⾡᝟ሗ༠఍ࠊ3ࠊ Ⓨห,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧Ⱚᓮኴ ᇶ♏ࢿࢱࢆᮏᙜ࡟♫఍ᐇ⿦ࡉࡏࡲࡏࢇ࠿㸽㹼ᐇ⏝໬◊✲࡛ᚲ㡲࡞ࠕၟရ໬
&RPPHUFLDOL]H  ࠖ࡜࠸࠺࿚⦡ࢆゎࡃ㹼 ᮾி㒔೺ᗣ㛗ᑑ་⒪ࢭࣥࢱ࣮+$,& ≉ูࢭ࣑ࢼ࣮
 ᮾி㒔ᯈᶫ༊ ⏣ᓥ㝧୍ 㛫ⴥ⣔ᖿ⣽⬊࡜ࡀࢇ⣽⬊ࡢ⼥ྜ㸽⼥ྜ⣽⬊࡟ࡼࡿࡀࢇ⤌⧊࡬ࡢᙳ㡪 ➨  ᅇឤᰁ⑕ࢧ࢖ࢺ࢝࢖ࣥ◊✲఍  ་⒪࢖ࣀ࣮࣋ࢩࣙࣥ᥎㐍ࢭࣥࢱ࣮㸦75,㸧◊ಟᐊ㸪රᗜ┴⚄ᡞᕷ
ࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ ධỤᩔࠊబ⸨୍ᶞࠊཎ೔ኴᮁࠊ࿴⏣⊛ࠊⰪᓮኴ ࢝࢜ࢳࣥᛶேᕤ࢜ࣜࢦ⢾࡜࣍ࢫ࣍ࣟࢳ࢜
࢚࣮ࢺಟ㣭ᆺ᰾㓟ࡢ⤌ࡳྜࢃࡏ࡟ࡼࡿ VL51$ ࡢᏳᐃ໬  ᪥ᮏ⸆⌮Ꮫ఍➨  ᖺ఍㹼 ᅜ❧ி㒔ᅜ㝿఍㤋㸪ி㒔ᗓி㒔ᕷ ͤ:HE 㛤ദ Ლཎ┤ᶞࠊᒣᮏ┤ᶞࠊᑠཎ㐨ἲࠊᏳ஭ᩥᙪࠊⰪᓮኴ +1 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘
࢖ࣝࢫࡢࢩ࢔ࣝ㓟㠀౫Ꮡⓗ࡞⣽⬊౵ධᶵᵓࡢゎᯒ ᪥ᮏ⸆⌮Ꮫ఍➨  ᖺ఍ 
㹼 ᅜ❧ி㒔ᅜ㝿఍㤋㸪ி㒔ᗓி㒔ᕷ ͤ:HE 㛤ദධỤᩔࠊబ⸨୍ᶞࠊཎ೔ኴᮁࠊ࿴⏣⊛ࠊⰪᓮኴ ࢝࢜ࢳࣥᛶேᕤ࢜ࣜࢦ⢾࡜࣍ࢫ࣍ࣟࢳ
࢚࣮࢜ࢺಟ㣭ᆺ᰾㓟ࡢ⤌ࡳྜࢃࡏ࡟ࡼࡿ VX51$ ࡢᏳᐃ໬ ᪥ᮏ⸆⌮Ꮫ఍➨  ᖺ఍㹼 ᅜ❧ி㒔ᅜ㝿఍㤋௚㸪ி㒔ᗓி㒔ᕷ ͤ:HE 㛤ദ ⏣ᓥ㝧୍ ␗࡞ࡿᛶ㉁ࡢ㛫ⴥ⣔ᖿ⣽⬊࡜ࡀࢇ⣽⬊࡜ࡢ⣽⬊⼥ྜࡢ᳨ウ ➨  ᅇ᪥ᮏศᏊ
－ 50 －

⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ࣭࣐࣓ࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ㰺⸨⣪ᕼࠊ⏣ᓥ㝧୍ࠊධỤᩔࠊᲚཎ┤ᶞࠊⰪᓮኴ ୖ⓶㛫ⴥ㌿᥮࡟࠾ࡅࡿ ,QW+,)Ș⤒

㊰ࡢᙺ๭ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ࣭࣐࣓ࣜࣥ
ࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧࡞ࡋ,9 ≉グ஦㡯࠙≉チฟ㢪ࠚ ࠕ࢝ࢳ࢜ࣥᛶேᕤ࢜ࣜࢦ⢾࡟ࡼࡿ஧㔜㙐 51$ ࡢᏳᐃ໬ࠖ㸦 ᅜእฟ㢪㸧࠙ᩍ⫱άືࠚ
Ⱚᓮኴ ᩥ㒊⛉Ꮫ┬ ⛉Ꮫᢏ⾡ᨻ⟇◊✲ᡤ ⛉Ꮫᢏ⾡ᑓ㛛ᐙࢿࢵࢺ࣮࣡ࢡ ⛉Ꮫᢏ⾡ືྥᑓ㛛ㄪᰝጤဨ  ᖺ  ᭶㹼 ᮾிࣂ࢖࣐࣮࣮࣭࢜࢝࢖ࣀ࣮࣋ࢩࣙࣥᢏ⾡◊✲⤌ྜ㸦72%,5$㸧タ❧ࠋ๪⌮஦㸤㐠Ⴀጤဨව௵  ᖺ  ᭶㹼 ྠ ௦⾲⌮஦  ᖺ  ᭶㹼 ࠕࢩࣥࢭ࣭ࣛࢸࢡࣀࣟࢪ࣮ࢬ㸦ᰴ㸧ࠖ⛉Ꮫ㢳ၥ  ᖺ  ᭶㹼 㡑ᅜ &XUDFOH,QF ⛉Ꮫ㢳ၥࠊ୰ᅜ 6KDQJKDL%,20('6FLHQFHDQG7HFKQRORJ\&R/WG ⛉Ꮫ㢳ၥ  ᖺ  ᭶㹼－ 51 －

ࣉࣟࢪ࢙ࢡࢺྡ

ㄆ▱⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 14 ௳㸧 ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N,
Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, Lee VM, Takahashi R, Suhara T,
Higuchi M, *Inoue H. Nasal vaccine delivery attenuates brain pathology and cognitive impairment
in tauopathy model mice. NPJ Vaccines. 2020 Mar 24;5:28.

2.

Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi
T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, *Baba K. Structurally distinct Į-synuclein fibrils
induce robust Parkinsonian pathology. Mov Disord 2020 Feb;35(2):256-267.

3.

Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura
K, Hasegawa M, *Shiio Y. Corticobasal degeneration with deep white matter lesion diagnosed bybrain biopsy. Neuropathology. 2020 Jan 10.

4.

Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, MoriA, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K, Morita M, Hasegawa M, Hasegawa
K, Elahi M, Motoi Y, Hasegawa I, Funayama M, Okano H, Akamatsu W, Imai Y, *Hattori N.
Mutations in CHCHD2 accelerate Į-synuclein aggregation. Hum Mol Genet 2019 Dec
1;28(23):3895-3911.

5.

Grudina C, Kouroupi G, Nonaka T, Hasegawa M, Matsas R, *Zurzolo C. Human NPCs can degrade
Į-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly throughTNT-like structures. Neurobiol Dis. 2019 Dec;132:104609.

6.

Vargas JY, Loria F, Wu YJ, Córdova G, Nonaka T, Bellow S, Syan S, Hasegawa M, van Woerden GM,
Trollet C, *Zurzolo C. Wnt/Ca2+ pathway is involved in interneuronal communication mediated bytunneling nanotubes. EMBO J. 2019 Oct 18:e101230.

7.

Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C,
Yamashita C, Miki Y,Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T,
Hasegawa M, Okuzumi A, *Imai Y, *Hattori N. Parkinson's disease-associated iPLA2-VIA/PLA2G6
regulates neuronal functions and Į-synuclein stability through membrane remodeling. Proc Natl Acad
Sci U S A. 2019 Oct 8;116(41):20689-20699.

8.

Okamura Y, *Kawakami I, Watanabe K, Oshima K, Niizato K, Ikeda K, Akiyama H, Hasegawa M. Tau
progression in single severe frontal traumatic brain injury in human brains. J Neurol Sci 2019 Oct 9;407:116495.

9.

Coudert L, Nonaka T, Bernard E, Hasegawa M, Schaeffer L, *Leblanc P. Phosphorylated andaggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt)
polyglutamine expression in human cellular models. Cell Mol Life Sci. 2019 Jul;76(13): 2615-2632.

10. Fujita K, Matsubara T, Miyamoto R, Sumikura H, Takeuchi T, Maruyama Saladini K, Kawarai T,
Nodera H, Udaka F, Kume K, Morino H, Kawakami H, Hasegawa M, Kaji R, Murayama S, *Izumi－ 52 －

Y. Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinicalpathological case report. BMC Neurol. 2019 Jul 18;19(1):168.
11. Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T,
Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, *Hisanaga SI. Tau isoform expression andphosphorylation in marmoset brains. J Biol Chem. 2019 Jul 26;294(30):11433-11444.
12. Shimozawa A, Fujita Y, Kondo H, Takimoto Y, Terada M, Sunagi M, Hisanaga SI, *Hasegawa M,. Effectof L-DOPA/benserazide on propagation of pathological Į-synuclein. Front Neurosci 2019 Jun 14;13:595.
13. Lavenir I, Passarella D, Masuda-Suzukake M, Curry A, Holton JL, Ghetti B, *Goedert M. Silver
staining (Campbell-Switzer) of neuronal Į-synuclein assemblies induced by multiple system atrophy
and Parkinson's disease brain extracts in transgenic mice. Acta Neuropathol Commun. 2019 Sep
16;7(1):148.
14. Hatsuta H, Takao M, Nogami A, Uchino A, Sumikura H, Takata T, Morimoto S, Kanemaru K, Adachi
T, Arai T, Hasegawa, M and *Murayama S. Tau and TDP-43 accumulation of the basal nucleus of
Meynert in individuals with cerebral lobar infarcts or hemorrhage. Acta Neuropathol Commun
2019, 7:49.
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 18 ௳㸧
1.

*Hasegawa M. Structure of NFT: Biochemical Approach. Adv Exp Med Biol. 2019; 1184:23-34.
㸦ᰝㄞ࠶ࡾ㸧

2.

*Nonaka T, Hasegawa M. Prion-like properties of assembled TDP-43. Curr Opin Neurobiol. 2019
Dec 17;61:23-28. 㸦ᰝㄞ࠶ࡾ㸧

3.

Tarutani A, *Hasegawa M. Prion-like propagation of Į-synuclein in neurodegenerative diseases.
Prog Mol Biol Transl Sci. 2019, 168:323-348.㸦ᰝㄞ࠶ࡾ㸧

4.

Kawakami I, Arai T, *Hasegawa M. The basis of clinicopathological heterogeneity in TDP-43
proteinopathy. Acta Neuropathol 2019 Nov;138(5):751-770.㸦ᰝㄞ࠶ࡾ㸧

5.

*Josephs KA, Mackenzie I, Frosch MP, Bigio EH, Neumann M, Arai T, Dugger BN, Ghetti B,
Grossman M, Hasegawa M, Herrup K, Holton J, Jellinger K, Lashley T, McAleese KE, Parisi JE,
Revesz T, Saito Y, Vonsattel JP, Whitwell JL, Wisniewski T, Hu W. LATE to the PART-y. Brain. 2019
Sep 1;142(9):e47.㸦ᰝㄞ࠶ࡾ㸧

6.

*Masuda-Suzukake M, Hasegawa M. Prion-like Propagation of Pathological Į-Synuclein in Vivo.
Yakugaku Zasshi. 2019;139(7):1007-1013. doi: 10.1248/yakushi.18-00165-4. 㸦ᰝㄞ࠶ࡾ㸧7.

㛗㇂ᕝᡂே: ㄆ▱⑕ࡢ⑓ែᙧᡂ࡜㐍⾜ᶵᵓ BIOSCIENCE & INDUSTRY 77, 354-359, 2019.
㸦ᰝㄞ࠶ࡾ㸧

8.

ட㇂ᐩ⏤ᶞࠊ㛗㇂ᕝᡂே Aȕ ࡢఏ᧛ Clin Neurosci 37, 59-61, 2019.㸦ᰝㄞ࡞ࡋ㸧

9.

ୗἑ᫂ᕼࠊ㛗㇂ᕝᡂே ࢱ࢘⺮ⓑ. 㠀ᐃᆺࣃ࣮࢟ࣥࢯࢽࢬ࣒㸫ᇶ♏࡜⮫ᗋ㸫, ୗ⏿ாⰋ⦅㞟 ᩥගᇽ 2019. 㸦ᰝㄞ࡞ࡋ㸧10. ᶡ㇂ឡ⌮ࠊ㛗㇂ᕝᡂே Șࢩࢾࢡࣞ࢖ࣥ࡜ࣉࣜ࢜ࣥᵝఏ᧛. Clin Neurosci 37, 1068-72,
2019. 㸦ᰝㄞ࡞ࡋ㸧
11. ⣽ᕝ㞞ேࠊ㛗㇂ᕝᡂே ࢱ࢘ࡢࣉࣜ࢜ࣥᵝఏ᧛ࣔࢹࣝ YAKUGAKU ZASSHI 139(7): 1021-1025, 2019.
㸦ᰝㄞ࡞ࡋ㸧
12. 㔝୰㝯 ⣽⬊ෆ␗ᖖࢱࣥࣃࢡ㉁ࡢࣉࣜ࢜ࣥᵝᛶ㉁ Dementia Japan, 33: 39-45, 2019㸦ᰝㄞ࡞ࡋ㸧－ 53 －

13. ⣽ᕝ㞞ே ࣉࣟࢢࣛࢽࣗࣜࣥ 㠀ᐃᆺࣃ࣮࢟ࣥࢯࢽࢬ࣒㸫ᇶ♏࡜⮫ᗋ㸫ᩥගᇽ 209-215,2019.
㸦ᰝㄞ࡞ࡋ㸧
14. 㕥᥃㞞⨾ Į ࢩࢾࢡࣞ࢖ࣥ⬻ෆఏ᧛ࡢື≀ࣔࢹࣝ ᪥ᮏ⸆⌮Ꮫ఍ㄅ㸦ᰝㄞ࡞ࡋ㸧15. 㛗㇂ᕝᡂே ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢ἞⒪⸆㛤Ⓨ㸫࢔࣑ࣟ࢖ࢻ௬ㄝࡣṇࡋ࠸࠿㸽㸫 ་⒪ⓑ
᭩ 2019 ᖺᗘ∧ࠊすᮧ࿘୕┘ಟࠊ᪥ᮏ་⒪௻⏬ 46-52, 2019.㸦ᰝㄞ࡞ࡋ㸧
16. Hosokawa M and Arai T, Progranulin and Frontotemporal Lobar Degeneration (Chapter 3),
Progranulin and Central Nervous System Disorders, Editors: Hara H, Hosokawa M, Nakamura S,
Shimohata T, and Nishihara M. 35-69, Springer Nature, Singapore, 2019.
17. Hosokawa M, PGRN and Neurodegenerative Diseases Other Than FTLD (Chapter 4), Progranulin
and Central Nervous System Disorders, Editors: Hara H, Hosokawa M, Nakamura S, Shimohata T,
and Nishihara M. 71-84, Springer Nature, Singapore, 2019.
18. Hosokawa M, Progranulin and Inflammation/Neuroinflammation (Chapter 7), Progranulin andCentral Nervous System Disorders, Editors: Hara H, Hosokawa M, Nakamura S, Shimohata T, andNishihara M. 117-126, Springer Nature, Singapore, 2019.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 9 ௳㸧1.

Hasegawa M: Į-SYNUCLEIN - CAN IT FORM PRIONS ?. World Congress of Neurology 2019
(WCN2019). 2019.10.30, UAE.

2.

㛗㇂ᕝᡂே ๓㢌ⴥഃ㢌ⴥኚᛶ⑕㸦FTLD㸧␗ᖖከ㞵࣭TDP-43 ࢱࣥࣃࢡ㉁ ࣞࢠࣗࣛࢺࣜ
࣮ࢧ࢖࢚ࣥࢫ࢚࢟ࢫࣃ࣮ࢺ◊ಟ఍ 2019.11.12 ᮾி㒔

3.

㛗㇂ᕝᡂே ࢱࣥࣃࢡఏ᧛࡛ㄝ᫂ࡍࡿㄆ▱⑕ ᶓ㡲㈡࣭୕ᾆ⢭⚄⛉་఍ㅮ₇఍ 2019.9.13
⚄ዉᕝ┴ᶓ㡲㈡ᕷ

4.

㛗㇂ᕝᡂே Șࢩࢾࢡࣞ࢖ࣥఏ᧛࡛⪃࠼ࡿࣃ࣮࢟ࣥࢯࣥ⑓࡜ࡑࡢ㛵㐃⑌ᝈ ➨ 26 ᅇ᪂₲⢭⚄⑌ᝈ◊✲఍ 201.9.5 ᪂₲┴

5.

㛗㇂ᕝᡂே ࣉࣜ࢜ࣥᵝఏ᧛ᐇ㦂࡜ Braak ௬ㄝ ➨ 60 ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍⥲఍Ꮫ⾡◊✲఍ 2019.7.15 ࢘࢖ࣥࢡឡ▱㸪ឡ▱┴ྡྂᒇᕷ

6.

㛗㇂ᕝᡂே ㄆ▱⑕࡜ࣉࣜ࢜ࣥᵝఏ᧛ ➨ 10 ᅇᮐᖠ⚄⤒⛉Ꮫ◊✲఍ 2019.6.26 ໭ᾏ㐨ᮐᖠᕷ7.

㛗㇂ᕝᡂே ㄆ▱⑕ࡢⓎ⑕ࠊ㐍⾜ᶵᵓ ᪥ᮏᏛ⾡᣺⯆఍᪥㡑◊✲⪅஺ὶ఍ࢩ࣏ࣥࢪ࣒࢘
2019.5.24 㡑ᅜ㸪ࢯ࢘ࣝ8.

Hasegawa M: Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies Prion-Like Seeded Aggregation and Phosphorylation-. 3rd ITCN & 2019 AMTNS. 2019.5.4. Taipei.

9.

Hasegawa M: The possible mechanism of Į-synuclein spreading in Parkinson disease. 3rd ITCN
& 2019 AMTNS. 2019.5.4. Taipei.

ࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

*㕥᥃㞞⨾ࠊGoedert Michelࠊ㛗㇂ᕝᡂே 㔝⏕ᆺ࣐࢘ࢫࢆ⏝࠸ࡓ᪂つࢱ࢘ఏ᧛ࣔࢹࣝ ➨38 ᅇㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍ 2019.11.8 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊

2.

*㕥᥃㞞⨾ࠊ㛗㇂ᕝᡂே ື≀ࣔࢹࣝ࡟࠾ࡅࡿ Į ࢩࢾࢡࣞ࢖ࣥఏ᧛ ➨ 38 ᅇㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍ 2019.11.7 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊－ 54 －

3.

*⣽ᕝ㞞ேࠊୗἑ᫂ᕼࠊ㕥᥃㞞⨾ࠊタᵹᾈᚿࠊ᪂஭ဴ᫂ࠊ㛗㇂ᕝᡂே ࢱ࢘ࡢࣉࣜ࢜ࣥᵝఏ᧛ࣔࢹ࣐ࣝ࢘ࢫ ➨ 38 ᅇㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍ 2019.11.7 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊4.

Ώ㎶ுᖹࠊᮾ᫴஧ࠊἙୖ⥴ࠊ኱ᓥ೺୍ࠊ᪂㔛࿴ᘯࠊ㔝୰㝯ࠊ㛗㇂ᕝᡂேࠊ᪂஭ဴ᫂ ➽ⴎ⦰ᛶഃ⣴◳໬⑕ࡢ⬨㧊๓ゅ⣽⬊࡟࠾ࡅࡿ RNA ⤖ྜ⺮ⓑ㉁ Ataxin-2 ࡢᒁᅾ ➨ 24 ᅇ⚄⤒⢭⚄་Ꮫ఍Ꮫ⾡㞟఍ 2019.10.25 ᒣᙧࢸࣝࢧ㸪ᒣᙧ┴ᒣᙧᕷ

5.

Masuda-Suzukake M, Hasegawa M Animal models of synucleinopathies: prion-like propagation ofalpha-synuclein in non-transgenic animals The 6th congress of ASCNP

2019.10.13 Fukuoka

International Congress Center㸪⚟ᒸ┴⚟ᒸᕷ
6.

Hosokawa M, Hasegawa M. Development of tau propagation mice model. 6th Congress of Asian
College of Neuropsychopharmacology 2019.10.13 Fukuoka International Congress Center㸪⚟ᒸ┴⚟ᒸᕷ

7.

⣽ᕝ㞞ே ࢱ࢘ࡢࣉࣜ࢜ࣥᵝఏ᧛ࣔࢹ࣐ࣝ࢘ࢫ ➨ 66 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍ 2019.5.15㹼
5.17 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯1.

⣽ᕝ㞞ே ࠕࢱ࢘ࡢࣉࣜ࢜ࣥᵝఏ᧛ࣔࢹ࣐ࣝ࢘ࢫࠖ࡟ᑐࡋࠊ➨ 38 ᅇ᪥ᮏㄆ▱⑕Ꮫ఍Ꮫ⾡
ዡບ㈹㸦ᇶ♏◊✲㒊㛛㸧ཷ㈹－ 55 －

ࣉࣟࢪ࢙ࢡࢺྡ

I.

Ꮫ⩦グ᠈ࣉࣟࢪ࢙ࢡࢺ

ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧ᰝㄞ࠶ࡾ1.

Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi
M, Sakuma H. (2020). Extracellular ADP augments microglial inflammasome and NF-țB activation
via the P2Y12 receptor. Eur J Immunol. 50, 205-219. doi: 10.1002/eji.201848013.

2.

Matsuno M, Horiuchi J, Ofusa K, Masuda T, Saitoe M*. (2019). Inhibiting glutamate activity duringconsolidation suppresses age-related long-term memory impairment in Drosophila. iScience 15, 55-65.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧
1.

*Yoshinori SuzukiࠊJonathan E.SchenkࠊQuentin Gaudry Paracrine serotonin modulates postsynaptic gain via dedicated interneurons in Drosophila olfaction ᪥ᮏẚ㍑⏕⌮⏕໬Ꮫ఍➨ 41 ᅇᮾி኱఍ 2019.11.30㹼12.1 ᮾி኱Ꮫඛ➃⛉Ꮫᢏ⾡◊✲ࢭࣥࢱ࣮㸪ᮾி㒔┠㯮༊

2.

㰺⸨ᐇ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࠿ࡽ⪃ᐹࡍࡿグ᠈ᅇ㊰ ➨ 253 ᅇࡘࡃࡤࣈࣞ࢖ࣥࢧ࢖࢚ࣥࢫ࣭ࢭ࣑
ࢼ࣮ 2019.11.19 ⟃Ἴ኱Ꮫ་Ꮫ࢚ࣜ࢔೺ᗣ་⛉Ꮫ࢖ࣀ࣮࣋ࢩࣙࣥᲷ 8 㝵ㅮᇽ㸪Ⲉᇛ┴ࡘࡃࡤᕷ

3.

*Minoru SaitoeࠊKohei UenoࠊShintaro NaganosࠊJunjiro Horiuchi Non-canonical local dopamine
release evoked by postsynaptic neurons The 13th Chinese Neuroscience Society Bennial Meeting2019.10.13 Shanghai㸪China

4.

Minoru Saitoe Non-canonical local dopamine release evoked by postsynaptic neurons ௧࿴ඖᖺᗘ⏕⌮◊◊✲఍ࠕグ᠈◊✲఍ࠖ 2019.9.12 ⏕⌮Ꮫ◊✲ᡤ㸪ឡ▱┴ᒸᓮᕷ5.

ᐑୗ▱அ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⾜ືᏛ㹼ໝ࠸᎘ᝏᏛ⩦୰ᚰ࡟㹼 ➨ 31 ᅇ᪥ᮏ⾜ື⚄⤒ෆศἪ◊✲఍ 2019.9.2㹼9.4 ࢭ࣑ࢼ࣮ࣉࣛࢨࣟ࢖ࣖࣝࣇࢪ㸪ᒣ᲍┴Ἑཱྀ†⏫

6.

*Kohei Ueno ࠊMinoru Saitoe A novel mode of dopamine release gated by postsynaptic activity ,2020.6.4 Institute of Molecular biology in Academia , Sinica , Taiwanࡑࡢ௚ 㸦ィ 8 ௳㸧⮬⏤ᥖ㍕
1.

*ᯇ㔝ඖ⨾ࠊୖᮧᮃ ࠊ኱ᡣிᏊ ࠊᇼෆ⣧஧㑻ࠊ㰺⸨ᐇ ຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖࡣᏛ⩦ᚋࡢ᝿㉳ࢻ࣮ࣃ࣑ࣥసືᛶ⚄⤒ࡢ㐣๫⯆ዧ࡟ࡼࡾ⏕ࡌࡿ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3
࣐࣓ࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ－ 56 －

2.

*㕥ᮌຊ᠇ࠊQuentin Gaudry ഐศἪᛶ࡜ࢩࢼࣉࢫᛶࢭࣟࢺࢽࣥࡣࢩࣙ࢘ࢪࣙ࢘ࣂ࢚Ⴅぬ⣔࡟࠾࠸࡚␗࡞ࡿࢩࢢࢼࣝ⤒㊰࡛┦཯ࡍࡿ⚄⤒ಟ㣭ࢆᢸ࠺ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍
2019.12.3 ࣐࣓ࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ

3.

*ᐑୗ▱அ Ensheathing Glia ࠿ࡽࡢᑠ⬊ᛶࢢࣝࢱ࣑ࣥ㓟ᨺฟࡀࠊ㐃ྜᏛ⩦࡟࠾ࡅࡿ᎘ᝏ᝟ሗ
ࢆఏ㐩ࡍࡿ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3 ࣐࣓ࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ

4.

*Kohei UenoࠊMinoru Saitoe A novel mode of dopamine release gated by postsynaptic activity ᪥ᮏẚ㍑⏕⌮⏕໬Ꮫ఍➨ 41 ᅇᮾி኱఍ 2019.11.30㹼12.1 ᮾி኱Ꮫඛ➃⛉Ꮫᢏ⾡◊✲ࢭࣥࢱ࣮㸪ᮾி㒔┠㯮༊

5.

*ᐑୗ▱அࠊ୕ୖᜤᖹࠊ㐲⸨ሀኴ㑻ࠊᐑᆅᏕ᫂ࠊ᳃ᒣబ࿴Ꮚࠊ௒㔝ᖾኴ㑻ࠊ᳃ᒣⰾ๎ࠊΏ㎶㞞ᙪࠊ㰺⸨ᐇ Ensheathing Glia ࠿ࡽࡢᑠ⬊ᛶࢢࣝࢱ࣑ࣥ㓟ᨺฟࡀࠊ㐃ྜᏛ⩦࡟࠾ࡅࡿ᎘ᝏ
᝟ሗࢆఏ㐩ࡍࡿ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.27 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

6.

*ୖᮧᮃ ࠊᯇ㔝ඖ⨾ࠊᇼෆ⣧஧㑻ࠊ㰺⸨ᐇ ຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖࡢཎᅉ࡜࡞ࡿグ᠈㐣⛬ࡢ≉ᐃ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.27 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

7.

*㛗㔝ៅኴ㑻ࠊ㰺⸨ᐇ グ᠈ᙉ໬࡜᝿㉳ࡣ␗࡞ࡿࢻ࣮ࣃ࣑ࣥ⚄⤒ࡀᢸ࠺ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.26 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ8.

*ୖ㔝⪔ᖹࠊ㰺⸨ᐇ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚⬻࡟࠾࠸࡚ࢻࣃ࣑ࣥᨺฟࢆㄏᑟࡍࡿࢢ࢔ࢽࣝ㓟ࢩࢡ࣮ࣛࢮࡢྠᐃ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.26 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 6 ௳㸧
1.

ୖᮧᮃ  ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.6 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ

2.

㕥ᮌຊ᠇ ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.6 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ3.

㯮ぢᆠ  ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.6 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ

4.

ᐑୗ▱அ ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.6 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ5.

ୖ㔝⪔ᖹ ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.5 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ

6.

㛗㔝ៅኴ㑻 ➨ 12 ᅇศᏊ㧗ḟ⬻ᶵ⬟◊✲఍ 2019.9.5 ࣍ࢸࣝ༓⛅㛶㸪ᒾᡭ┴ⰼᕳᕷ

IV. ≉グ஦㡯
࠙◊✲఍ࠚ
1.


➨ 12 ᅇศᏊ㧗ḟᶵ⬟◊✲఍ࠕ࢖ࣀ࣮࣋ࢩࣙࣥ࡜࣮࣒࣑࣍࢝ࣥࢢࡀ⧊ࡾ࡞ࡍḟୡ௦⬻⛉Ꮫࠖ௻⏬࣭㐠Ⴀ㸦ⰼᕳἨ㸧 2019.9.5㹼9.7

࠙ཷ㈹ࠚ
1. 㰺⸨ᐇ ᖹᡂ 31 ᖺᗘᩥ㒊⛉Ꮫ኱⮧⾲ᙲ⛉Ꮫᢏ⾡㈹㸦◊✲㒊㛛㸧ཷ㈹2019 The Commendation for Science and Technology by the Minister of Education, Culture, Sports,
Science and Technology. Prizes for Science and Technology (Research Category)ࠕຍ㱋࡜⏕⌮≧ែ࡟ࡼࡾኚ໬ࡍࡿグ᠈ᶵᵓࡢ◊✲ࠖ 2019.4.17－ 57 －

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 すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ࡼࡿ⬻ᶵ⬟෌ᘓ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ྜྠ኱఍ 1HXUR  ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ࡼࡿ⬻ᶵ⬟෌ᘓ ➨  ᅇ⚄⤒⛉Ꮫ◊✲఍㸦኱ሯ〇⸆㸧 ࣍ࢸࣝㄯ㟢㤋㸪ᒣ᲍┴⏥ᗓᕷࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕
 6X]XNL 0 1LVKLPXUD< ⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟ࢆᨭ࠼ࡿ⭡ഃ⥺᮲యࡢ἞⒪ᶆⓗ࡜ࡋ࡚ࡢྍ⬟ᛶ ➨  ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍ 㹼 ูᗓᅜ㝿ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮
ࣅ࣮ࢥࣥࣉࣛࢨ㸪኱ศ┴ูᗓᕷ .DZDL . 7D]HR 7 1LVKLPXUD <  $FWLYDWLRQ RI KXPDQ VSLQDO ORFRPRWRU FLUFXLWU\ XVLQJWUDQVYHUWHEUDO PDJQHWLF VWLPXODWLRQ  ➨  ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍ 㹼 ูᗓᅜ㝿ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮ ࣅ࣮ࢥࣥࣉࣛࢨ㸪኱ศ┴ูᗓᕷ 6KR6XJDZDUD 97$0SDWKZD\FRQWULEXWHVWRKXPDQPRWLYDWHGPRWRURXWSXWV %UDLQ6WRUPLQJ
RQ3ULPDWH&RQQHFWRPH  ⚄ᡞ⌮໬Ꮫ◊✲ᡤ㸪රᗜ┴⚄ᡞᕷ

77D]RHࠊ 06X]XNLࠊ0.DQHVKLJH ࠊ.,ZDWVXNLࠊ<1LVKLPXUD 1RQLQYDVLYH WUDQVYHUWHEUDOPDJQHWLFVWLPXODWLRQGLVFORVHVUHVLGXDOPRWRUIXQFWLRQRIVXEOHVLRQDOVSLQDOFLUFXLWU\LQKXPDQVZLWKVSLQDOFRUGLQMXU\ 6RFLHW\IRU1HXURVFLHQFH  &KLFDJR㸪86$ᶓᒣಟࠊすᮧᖾ⏨ ๓㢌║㔝࡜⿵㊊║㔝࡟ࡼࡿど✵㛫ᛶὀពไᚚࡢ⚄⤒࣓࢝ࢽࢬ࣒
➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ㕥ᮌ㏔ㄹࠊすᮧᖾ⏨ 㞴᫆ᗘࡀ㧗࠸㐠ືᐇ⾜୰࡟ഃᆘ᰾୍㐠ື㔝㛫ࡢᶵ⬟㐃㛵ࡀฟ⌧ࡍࡿ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ୰ᒣ⩏ஂࠊᶓᒣಟࠊᫍⱥྖ 㐠ືࡢไᚚ࡟࠾ࡅࡿ୍ḟ㐠ື㔝࠾ࡼࡧෆഃ㐠ື㔝ࡢ⚄⤒⣽⬊άື࡜ᒁᡤࣇ࢕࣮ࣝࢻ㟁఩ࡢ㛵୚ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ－ 59 －

 6KR6XJDZDUD<RVKLKLVD1DND\DPD0DVDNL)XNXQDJD7HWVX\D<DPDPRWR1RULKLUR6DGDWRDQG
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ࠊ᪩✄⏣኱Ꮫ ๰㐀⌮ᕤᏛ㒊㸦 ྡ㸧࠙᪂⪺グ஦ࠚ  ᪥⤒⏘ᴗ᪂⪺ࠕேᕤ⚄⤒࡛ᡭ㊊ື࠿ࡍࠖࠕ⬨㧊ᦆയ࣭⬻᱾ሰࠊᅇ᚟᪩ࡃࠖ  ẖ᪥᪂⪺࣊ࣝࢫࢹ࣮ࢽ࣮ࣗࢫ ⬻᱾ሰࡢࢧࣝ ࡲࡦࡋࡓᡭࡀࠕேᕤ⚄⤒࡛ࠖᅇ᚟  ᪥ᮏ⤒῭᪂⪺㟁Ꮚ∧࡟グ஦ᥖ㍕ࠕᡭࡢ㐠ືᶵ⬟ࢆᣢࡓ࡞࠸⬻㡿ᇦ࡟ேᕤ⚄⤒᥋⥆ࢩࢫࢸ࣒ࢆ౑ࡗ࡚ࠊ᪂ࡓ࡟㐠ືᶵ⬟ࢆ௜୚ࡍࡿࡇ࡜࡟ᡂຌࠖ  ᪥⤒⏘ᴗ᪂⪺࡟グ஦ᥖ㍕ࠕ㐠ື┤๓ࠊ⬻ࡀ➽⫗ࡢືࡁண－ 60 －

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,9 ≉グ஦㡯࡞ࡋ－ 64 －

ࣉࣟࢪ࢙ࢡࢺྡ

I.

⚄⤒⣽⬊ศ໬ࣉࣟࢪ࢙ࢡࢺ

ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 3 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Sánchez-Valpuesta M, Suzuki Y, Shibata Y, Toji N, Ji Y, Afrin N, Asogwa CN, Kojima I, Mizuguchi
D, Kojima S, Okanoya K, Okado H, Kobayashi K, Wada K. Corticobasal ganglia projecting neurons are
required for juvenile vocal learning but not for adult vocal plasticity in songbirds. Proc Natl Acad Sci U
S A. 2019 Nov 5;116(45):22833-22843. doi: 10.1073/ pnas.1913575116. Epub 2019 Oct 21.

2.

Yamasaki S, Ando S, Richards M, Hatch SL, Koike S, Fujikawa S, Kanata S, Endo K, Morimoto Y,
Arai M, Okado H, Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K, Nishida A. Maternal
diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old
offspring: A population-based birth cohort study. Schizophr Res. (2019) 206:52-57

3.

Kita M, Nakae J, Kawano Y, Asahara H, Takemori H, Okado H, Itoh H. (2019) Zfp238 regulates thethermogenic program in cooperation with Foxo1. iScience. 12:87-101.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1.

*Okado H. (2019) Regulation of brain development and brain function by the transcriptional
repressor RP58. Brain Res. 1705:15-23.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Yasuto Kunii, Makoto Arai, Haruo Okado. Novel
schizophrenia phenotype that is found a created mouse model caused by nutritional environment.
6thAsCNP 2019,  2019.10.10㹼10.12 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

2.

Tomoko Tanaka, Shinobu Hirai, Masato Hosokawa, Takashi Saito, Takaomi Saido, Masato
Hasegawa, Haruo Okado.

Induction of Alzheimer’s disease pathology by early life stress

6thAsCNP 2019,  2019.10.10㹼10.12 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ
3.

Tomoko Tanaka , Okado Haruo. Mechanism for the maintenance of cognitive function ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 20199.7.25㹼7.28 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

4.

᪂ಖ⿱Ꮚࠊᖹ஭ᚿఙࠊ⏣୰ᬛᏊࠊ⏣୰ㅬ஧ࠊᒸᡞᬕ⏕ ᡂయ࡛ࡢ RP58 Ⓨ⌧ᢚไࡣㄆ▱ᶵ⬟పୗࢆច㉳ࡍࡿ  ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 20199.7.25㹼7.28 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

5.

ᖹ஭ᚿఙࠊ᪂஭ㄔࠊ୕㍯⚽ᶞࠊᅧ஭Ὀேࠊ᪥㔝⍞ᇛࠊ㛗ᒸᩔᏊࠊ▮㒊༤ࠊᒸᡞᬕ⏕ ᰤ㣴

－ 65 －

⎔ቃ౫Ꮡⓗ࡞᪂つ⤫ྜኻㄪ⑕ࣔࢹ࣐ࣝ࢘ࢫࡼࡾᚓࡽࢀࡓ᪂ࡓ࡞୰㛫⾲⌧ᆺ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 20199.7.25㹼7.28 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷHirai S, Arai M, Kunii Y, Miwa H, Okado H. Creating a novel schizophrenia model mouse caused
by a combination of nutritional environment and genetic risk and characterization of the onset
mechanism. 14th World Congress of Biological Psychiatry. 2019.6.4 Vancouver, Canadaᖹ஭ᚿఙࠊ᪂஭ㄔࠊ୕㍯⚽ᶞࠊᅧ஭Ὀேࠊ᪥㔝⍞ᇛࠊ㛗ᒸᩔᏊࠊ▮㒊༤⯆ࠊᒸᡞᬕ⏕ ᰤ㣴⎔ቃ࡜㑇ఏⓗせᅉࡢ⤌ࡳྜࢃࡏ࡟ࡼࡾ⏕ࡌࡿ᪂ࡓ࡞⤫ྜኻㄪ⑕ࣔࢹ࣐ࣝ࢘ࢫࡢస〇࡜ࡑࡢⓎ⑕ᶵᗎࡢゎᯒ ➨14 ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ 2019.4.19㹼4.20 ໭ᾏ㐨኱ᏛᏛ⾡஺ὶ఍㤋㸪໭ᾏ㐨ᮐᖠᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯≉チฟ㢪 ฟ㢪␒ྕ 2019-136490 ᒸᡞᬕ⏕ࠊ᪂ಖ⿱Ꮚ ㌿෗ᢚไᅉᏊ RP58 ࡢⓎ⌧ไᚚྍ⬟࡞ࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ㠀ࣄࢺື≀ බ┈㈈ᅋἲேᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ฟ㢪᪥ 2019.7.24－ 66 －

ࣉࣟࢪ࢙ࢡࢺྡ⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧ᰝㄞ࠶ࡾ1.

㸨

Kamimura K, Odajima A, IkegawaY, MaruC,㸨Maeda N, (2019) The HSPG Glypican Regulates

Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP
Pathway. Cell Rep. 28, 3144-3156
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1. *Ohtaka-Maruyama C, Subplate neurons as an organizer of mammalian neocorticaldevelopment. Front. Neuroanat. 14,8 (2020)
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 8 ௳㸧1.

㸨୸ᒣ༓⛅ ࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢ⚄⤒άື࡟ࡼࡿ኱⬻᪂⓶㉁ᵓ⠏ࡢ࣓࢝ࢽࢬ࣒

2019 ᖺᗘ ⮬↛⛉Ꮫ◊✲ᶵᵓศ㔝⼥ྜᆺඹྠ◊✲஦ᴗ ࣮࣡ࢡࢩࣙࢵࣉࠕ㐠ື࣭⾜ື࠿ࡽ⣣ゎࡃ⬻⚄⤒ᅇ㊰Ⓨ㐩࣓࢝ࢽࢬ࣒ࡢ␗ศ㔝⼥ྜ࡟ࡼࡿゎ᫂ࠖ2020.2.18 ⮬↛⛉Ꮫ◊✲ᶵᵓ⏕⌮Ꮫ◊✲ᡤ㸪ឡ▱┴ᒸᓮᕷ2.

㸨୸ᒣ༓⛅ࠊ㔠Ꮚ஀ឡ ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ ⬻ᵓ⠏ࡢ“ሙ”࡜ࡋ࡚ࡢࢧࣈࣉ࣮ࣞࢺᒙࡢ኱⬻᪂⓶㉁Ⓨ⏕࡟࠾ࡅࡿᶵ⬟ ḟୡ௦⬻ࣉࣟࢪ࢙ࢡࢺ෤ࡢࢩ࣏ࣥࢪ࣒࢘ 2019.12.19 ୍ᶫㅮᇽ㸪ᮾி㒔༓௦⏣༊3.

㸨

Ohtaka-Maruyama C, Kaneko N, Fujii A, Hirai K, Yura K, Multifunction of subplate neurons in

the developing cerebral cortex 㸦࣮࣡ࢡࢩࣙࢵࣉ㸧 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3⚟ᒸᅜ㝿఍㆟ሙ࣭⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ&࣮࣭࣐࣓࣍ࣝࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ
4.

㸨

Ohtaka-Maruyama C, Subplate neurons function as an organizer in neocortical development

49th Annual Meeting of the Society for Neuroscience 2019.10.21 Chicago, U.S.A
5.

㸨

Ohtaka-Maruyama C,ࠕSubplate neurons function as key players in neocortical development andevolutionࠖ 21thTMIMS International SymposiumࠗOvercoming neuropsychopharmacology crisis࠘
2019.10.15 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
6.

Kamimura K, Drosophila Glypican Regulates Experience-dependent Synaptic and Behavioral Plasticity㸨Proteoglycans Future Leaders Symposium 2019 2019.9.28 ▼ᕝ㡢ᴦᇽ㸪▼ᕝ┴㔠ἑᕷ
7.

㸨

Ohtaka-Maruyama C, Subplate neurons function as key players in neocortical development andevolution  20thTMIMS International Symposium࣭Principles of Neocortical Development and
Evolution㸦➨ 20 ᅇ㒔་Ꮫ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘㸧 2019.7.30 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
8.

㸨

Ohtaka-Maruyama C. Molecular mechanisms for making specific neuronal circuits ✀≉␗ⓗ－ 67 －

⚄⤒ᅇ㊰ࡢᵓ⠏࡜సືཎ⌮ࡢゎ᫂ The 42nd Annual Meeting of the japan Neuroscience Society
2019.7.27 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷࡑࡢ௚ 㸦ィ 8 ௳㸧⮬⏤ᥖ㍕
1.

㸨㔠Ꮚ஀ឡ ࠊ୸ᒣ༓⛅ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ ⣽⬊እᇶ㉁ࣉࣟࢸ࢔࣮ࢮ࡟ࡼࡿⓎ⏕ᮇ኱⬻᪂⓶㉁ࡢࢧࢢࣉ࣮ࣞࢺᒙ࡟࠾ࡅࡿ⚄⤒⣽⬊⛣ືไᚚ ḟୡ௦⬻ࣉࣟࢪ࢙ࢡࢺ෤ࡢࢩ࣏ࣥࢪ
࣒࢘ 2019.12.18 ୍ᶫㅮᇽ㸪ᮾி㒔༓௦⏣༊
2.

㸨⚄ᮧᆂுࠊᑠ⏣ᔱឡᏊ ࠊ๓⏣ಙ᫂ ࢢࣜࣆ࢝ࣥࡣ⤒㦂౫Ꮡⓗ࡞ࢩࢼࣉࢫ࡜⾜ືࡢྍረᛶ

ࢆㄪ⠇ࡍࡿ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.4 ⚟ᒸᅜ㝿఍㆟ሙ࣭⚟ᒸࢧࣥࣃࣞࢫ
࣍ࢸࣝ&࣮࣭࣐࣓࣍ࣝࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ
3.

㸨㔠Ꮚ஀ឡ ࠊ୸ᒣ༓⛅ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ Ⓨ⏕ᮇ኱⬻᪂⓶㉁ࡢࢧࣈࣉ࣮ࣞࢺᒙ࡟࠾ࡅࡿ ECM

ࣜࣔࢹࣜࣥࢢࡣᨺᑕ≧⚄⤒⣽⬊⛣ືࢆไᚚࡍࡿ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3 ⚟ᒸᅜ㝿఍㆟ሙ࣭⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ&࣮࣭࣐࣓࣍ࣝࣜࣥࢵࢭ⚟ᒸ㸪⚟ᒸ┴⚟ᒸᕷ
4.

㸨

Kaneko N, Ohtaka-Maruyama C, Yura K, Maeda N, Extracellular matrix reorganization in the

subplate layer is important for the regulation or neuronal migration in the developingMeeting of the Society for Neuroscience 2019.10.20
5.

㸨

49th Annual

Chicago, U.S.A

Kamimura K, The HSPG Glypican Regulates Experience-dependent Synaptic and Behavioral

Plasticity by Modulating the Non-canonical BMP pathway  11th International Conference on
Proteoglycans 2019.9.30 ▼ᕝ㡢ᴦᇽ㸪▼ᕝ┴㔠ἑᕷ
6.

㸨

Kaneko N, Ohtaka-Maruyama C, Yura K, Maeda N,  ADAMTS2 regulates radial migration in

the developing cortex by reorganizing ECM in the subplate layer.

20thTMIMS International

Symposium࣭Principles of Neocortical Development and Evolution㸦➨ 20 ᅇ㒔་Ꮫ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘㸧 2019.7.30 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
7.

㸨㔠Ꮚ஀ឡ ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ࠊ୸ᒣ༓⛅  Radial neuronal migration in the neocortex isregulated by ADAMTS2 that reorganizes ECM in the subplate layer ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍
2019.7.27 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
8.

㸨⚄ᮧᆂுࠊᑠ⏣ᔱឡᏊ ࠊ๓⏣ಙ᫂ ࢢࣜࣆ࢝ࣥࡣ㠀ྂ඾ⓗ BMP ⤒㊰ࢆ௓ࡋ࡚⤒㦂౫Ꮡⓗ࡞ࢩࢼࣉࢫ࡜⾜ືࡢྍረᛶࢆㄪ⠇ࡍࡿ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.26 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1.

୸ᒣ༓⛅  ⬻ࡣ࡝ࡢࡼ࠺࡟ࡋ࡚࡛ࡁࡿࡢ࠿㸽 ࠥࢽ࣮ࣗࣟࣥ࠿ࡽ⬻࡬ࠥ 2019 ᖺᗘ㒔་Ꮫ◊㒔Ẹㅮᗙ➨ 3 ᅇࠗ㉥ࡕࡷࢇࡢ⬻ࢆࡍࡃࡍࡃ⫱࡚ࡿ࠘ 2019.07.14 ࢢ࣮࣮ࣜࣥ࣍ࣝ㸪ᮾி㒔ㄪᕸᕷ

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IV. ≉グ஦㡯࠙఍㆟୺ദࠚ
1.

୸ᒣ༓⛅ ➨ 20 ᅇ㒔་Ꮫ◊ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࠗPrinciples of Neocortical Development and
Evolution࠘୺ദ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ 2019.7.30

࠙ሗ㐨Ⓨ⾲ࠚ

－ 68 －

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⚄ᮧᆂு Tokyo MXࠊᮾி࢖ࣥࣇ࢛࣓࣮ࢩࣙࣥࠊ2019.11.26

2.

⚄ᮧᆂு ᮾி㒔⚟♴ಖ೺ᒁࠕࢩࢼࣉࢫࡢྍረᛶ࡟ࣉࣟࢸ࢜ࢢࣜ࢝ࣥࡀᚲせ࡛࠶ࡿࡇ࡜ࢆ
ゎ᫂ࠖ 2019.9.10

࠙♫఍άືࠚ
1.

୸ᒣ༓⛅ ᪥ᮏᏛ⾡᣺⯆఍ ≉ู◊✲ဨ➼ᑂᰝ఍ᑓ㛛ጤဨࠊᅜ㝿஦ᴗጤဨ఍᭩㠃ᑂᰝဨ࣭᭩㠃ホ౯ဨࠊMember, Dana Alliance for Brain Initiative (DABI)

2.

୸ᒣ༓⛅ ➨㸴ᅇ⌮⣔ዪᏊ◊✲஺ὶ఍(SWR)ࡢㅮホ⪅ཬࡧᑂᰝဨ㸦㒔❧ᡞᒣ㧗ᰯ㸧

3.

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ࣇ࢛࣮࣒ࣛୡヰே－ 69 －

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⤫ྜኻㄪ⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Berto S#, Mendizabal I#, Usui N#, Toriumi K#, Chatterjee P, Douglas C, Tamminga C, Preuss TM,
Yi SV2, *Konopka G. Accelerated evolution of oligodendrocytes in human brain. Proc Natl Acad
Sci USA (2019) in press. [# Co-first authors]2.

Mendizabal I#, Berto S#, Usui N#, Toriumi K#, Chatterjee P, Douglas C, Huh I, Jeong H, Layman
T, Tamminga CA, Preuss TM, *Konopka G, Yi SV. Cell-type specific epigenetic links toschizophrenia risk in brain. Genome Biol (2019) 20: 135. [#Co-first authors]3.

*Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, Vincent De Andrade, Francesco
De Carlo, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K,
Oshima K, Itokawa M, Arai M.Three-dimensional alteration of neurites in schizophrenia. Transl
Psychiatry (2019) 9:85.

4.

Yamasaki S, Ando S, Richards M, Hatch SL, Koike S, Fujikawa S, Kanata S, Endo K, Morimoto Y,
Arai M, Okado H, Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai, K, *Nishida A. Maternal
diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old
offspring: A population-based birth cohort study. Schizophr Res (2019) 206: 52-57.

5.

Z Zhao, S Jinde, S Koike, M Tada, Y Satomura, A Yoshikawa, Y Nishimura, R Takizawa, A Kinoshita,
E Sakakibara, H Sakurada, M Yamagishi, F Nishimura, A Inai, MNishioka, osuke Eriguchi, T Araki,
A Takaya, C Kan, M Umeda, A Shimazu, H Hashimoto, M Bundo, K Iwamoto, C Kakiuchi, *Kasai
K. Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia andits possible relation to neuronal migration-related genes. Translational Psychiatry (2019) 9: 289.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 28 ௳㸧
1.

*ᐑୗගᘯࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊྜྷᕝⲁࠊ㕥ᮌ୍ᾈࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ ⤫ྜኻㄪ⑕࡜⤊ᮎ⢾໬⏘≀, ಙᕞ་Ꮫ㞧ㄅ. 68(1): 23-30, 20202.

*⣒ᕝᫀᡂࠊᇼෆὈỤࠊᐑୗගᘯࠊ㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊ஭ୖᬛᏊࠊᑠᇼᬗᏊࠊỤ㉺ṇᩄࠊྜྷᕝⲁࠊỈ㇂㝯ኴࠊ᪂஭ㄔ ⢭⚄⑌ᝈࡢཎᅉ㏣ཬ࡜࢚ࣅࢹࣥࢫ࡟ࡘ࠸࡚ : ᩧ୍ᛶ࡜ᶆ‽໬⢭⚄⛉἞⒪Ꮫ 35(2), 177-185, 20203.

㞧㈡㔛஀ࠊ*Ỉ㇂㝯ኴࠊ➉⭜㐍ࠊ஭㔝ඖᬛᜨࠊ୰ᮧ┤ဢࠊ㫽ᒃὒኴࠊஂᓥ࿘ࠊධ㇂ಟྖࠊᑿ
ᓮ⣖ኵࠊ⣒ᕝᫀᡂࠊ኱ᓥ೺୍ࠊ᪂஭ㄔ ⚄⤒⣽⬊ࡢᙧࡢಶேᕪ࡜⤫ྜኻㄪ⑕⬻࡛ࡢᵓ㐀ኚ໬ ศᏊ⢭⚄་Ꮫ 19(4), 244-247, 20194.

*᪂஭ㄔࠊᐑୗගᘯ ᪂ࢩ࣮ࣜࢬࠓㅮᗙ ⢭⚄⑌ᝈࡢ⮫ᗋࠔࠕ⤫ྜኻㄪ⑕ࠖࢺࣆࢵࢡࢫ㸸᪂つ἞⒪ἲ㛤Ⓨ ୰ᒣ᭩ᗑ5.

*⣒ᕝᫀᡂ ⸆≀⒪ἲ⣔⤫┳ㆤᏛㅮᗙ ᑓ㛛ศ㔝 II ⢭⚄┳ㆤᏛձ⢭⚄┳ㆤࡢᇶ♏ ➨ 6 ∧་Ꮫ᭩㝔－ 73 －

6.

*⣒ᕝᫀᡂ ⤫ྜኻㄪ⑕἞⒪⸆㛤Ⓨ࡜ࢤࣀ࣒◊✲ࡢ⊃㛫࠿ࡽ̿⢭⚄⛉་ࡀㄒࡿࣔࣀ㸦ᐇែㄽ㸧࡜ࢥࢺ㸦≧ἣㄽ㸧㸫㙀⅍ OSAKA135 ྕ

7.

*⣒ᕝᫀᡂ ᐙ᪘ࡢどⅬࠕ⤫ྜኻㄪ⑕ࠖࠓㅮᗙ ⢭⚄⑌ᝈࡢ⮫ᗋࠔ୰ᒣ᭩ᗑ

8.

*⣒ᕝᫀᡂࠊᇼෆὈỤࠊᐑୗගᘯࠊ㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊỤ㉺ṇᩄࠊྜྷᕝⲁࠊỈ㇂㝯ኴࠊ᪂஭ㄔ
⢭⚄⑕≧࡜⑓ᅉࡢ㠀ᑐᛂ ⢭⚄⛉ 36(1), 77-85, 20209.

*⣒ᕝᫀᡂࠊ኱ᓥ೺୍ࠊ᪂஭ㄔࠊ㫽ᒃὒኴࠊஂᓥ࿘ࠊධ㇂ಟྖࠊᑿᓮ⣖ኵࠊ㞧㈡㔛஀ࠊỈ㇂㝯ኴ ᨺᑕගࢼࣀ CT ἲࢆ⏝࠸ࡓ⤫ྜኻㄪ⑕࡟࠾ࡅࡿ⚄⤒⣽⬊ࡢᵓ㐀ኚ໬ࡢゎᯒ㸫⬻⤌⧊ࡢᗄఱᏛ㸫㸬⢭⚄⤒ㄅ. 121 (12): 926-940, 201910. *⣒ᕝᫀᡂ ᕳ㢌ゝ㸸↓ព㆑ࡢ⦕㉳ㄽ㸬⏕≀Ꮫⓗ⢭⚄་Ꮫ఍ㄅ 30 (3), 201911. *Itokawa MࠊOshima KࠊArai MࠊTorii YࠊKushima IࠊIritani SࠊOzaki NࠊSaiga RࠊMizutani
R. Cutting edge morphological studies of postmortem brains of patients with schizophrenia andpotential applications of X-ray nanotomography (nano-CT). Psychiatry Clin Neurosci
Mar;74(3):176-182, 2020.
12. *⣒ᕝᫀᡂ ㄗゎࡉࢀࡀࡕ࡞㑇ఏᏊ࡜ᚰ ࡇࡇࢁࡢ೺ᗣ ➨ 61 ྕ:3-9ࠊ2019 ᖺ 7 ᭶
13. *⣒ᕝᫀᡂ ⤫ྜኻㄪ⑕ࡣ㑇ఏࡋࡲࡍ࠿㸫ࣔࣀࡢ⛉Ꮫࠊࢥࢺࡢ་Ꮫ㸫ࡇࡇࢁࡢ೺ᗣࡔࡼࡾ:
2-3ࠊ2019 ᖺ 6 ᭶
14. *⣒ᕝᫀᡂ ᚰࡢ⑓࡜ࡣ࡞࡟࠿㸫≀㉁࡜≀㉁࡛࡞࠸ࡶࡢ㸫  ➨ 11 ᅇࡳࢇ࡞ࡡࡗ࡜රᗜ኱

఍グ㘓ㄅ:48-62ࠊ2019 ᖺ 4 ᭶
15. *⣒ᕝᫀᡂࠊᐑୗගᘯࠊ᪂஭ㄔ ⮚ჾᶵ⬟ㄽ࡟ࡼࡿ㒊ရࡢ⛉Ꮫ㸫ᚰࡣ࡝ࡇࡲ࡛ࢱࣥࣃࢡ㉁࡞ࡢ࠿㸫≉㞟 III ⌧ᅾဴᏛ࡜⢭⚄་Ꮫ ⢭⚄⛉ VOL.34(3):298-305ࠊ2019.
16. ίఫె⨾ࠊ ᇼෆὈỤࠊᯇᯘᏹ⾜ࠊ*ᴋཎṇಇ ἞⒪㛤Ⓨ◊✲ࡢࢺࣆࢵࢡࢫ ஧ḟⓗᡤぢ࡜㑇ఏ࢝࢘ࣥࢭࣜࣥࢢ ⑓⌮࡜⮫ᗋ 37(6) 535-540ࠊ2019 ᖺ 6 ᭶
17. *Toriumi Kࠊ Suzuki KࠊMiyashita Mࠊ Horiuchi YࠊKobori Aࠊ Itokawa MࠊArai M. Glyoxalase
1 and mental illness. IMARS HIGHLIGHTS 14 (1): 14-17ࠊ201918. Saiga RࠊVincent De AndradeࠊFrancesco De CarloࠊTakeuchi AࠊUesugi KࠊTerada YࠊSuzuki Yࠊ
Takekoshi SࠊC InomotoࠊNakamura NࠊTorii YࠊKushima IࠊIritani SࠊOzaki NࠊOshima KࠊItokawa
MࠊArai Mࠊ*Mizutani R. Nanometer-Scale Structures of Neurons Differ Between Individuals and Those
Differences Become Extraordinary in Schizophrenia. Microsc. Microanal. 25 (Suppl 2)ࠊ2019.
19. *ྜྷᕝⲁࠊⳢཎㄔࠊ⣒ᕝᫀᡂࠊ⇃㇂┤ᶞ ⤫ྜኻㄪ⑕᪩ᮇᨭ᥼ࡢ⌧≧࡜௒ᚋࡢᒎᮃ㸫Ꮫᰯࢆࡵࡄࡿྲྀࡾ⤌ࡳࢆ୰ᚰ࡟㸫 ⢭⚄⛉ VOL.35(1) 115-123ࠊ 2019.
20. * ⣒ ᕝ ᫀ ᡂ  ⮚ ჾ ᶵ ⬟ ㄽ ࡟ ࡼ ࡿ 㒊 ရ ࡢ ⛉ Ꮫ 㸫 ᚰ ࡣ ࡝ ࡇ ࡲ ࡛ ࢱ ࣥ ࣃ ࢡ ㉁ ࡞ ࡢ ࠿ 㸫
PSYCHIATRY ⢭⚄⛉ VOL.34 No.3:298-305ࠊ2019
21. *⣒ᕝᫀᡂ ᚰࡢ⑓࡜ࡣ࡞࡟࠿㸫⭊࡟ⴠࡕࡿ≀ㄒࡀᅇ᚟ࢆࡶࡓࡽࡍ ᭶หࡳࢇ࡞ࡡࡗ࡜ 3
᭶ྕ:6-7ࠊ2019 March
22. *⣒ᕝᫀᡂ ࢖ࢽࢩ࢚࣮ࢩࣙࣥ࡜ࡋ࡚ࡢ⑓ (12)▼⚄ࡢࡇࡇࢁ ࡇࡇࢁࡢ⛉Ꮫ No.204:90-96 2019 March
23. *᪂஭ㄔࠊᐑୗගᘯࠊྜྷᕝⲁࠊ㕥ᮌ୍ᾈࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊ⣒ᕝᫀᡂ ࣅࢱ࣑ࣥ B6 ࡜⤫ྜኻㄪ⑕ ⮫ᗋ⢭⚄་Ꮫ 48(1):63-73ࠊ201924. *⣒ᕝᫀᡂ ⬻࡜ᚰࡢ⪃ྂᏛ㸫⤫ྜኻㄪ⑕࡜ࡣఱࡔࢁ࠺࠿㸫᪥ᮏホㄽ♫㸦༳ๅ୰㸧
25. *⣒ᕝᫀᡂࠊ㜰஭୍㞝ࠊΎỈ┿⌮ࠊΎỈ⩏㞝ࠊ᭮Ⰻ୍㑻ࠊ㧗ᰗ㝧୍㑻ࠊᴙᯘ⩏Ꮥࠊ⏣୰ᚭᖹࠊ⏣୰᭷ྐࠊᯇ⏣ኴ㑻ࠊỈ㔝㸦ᯇᮏ㸧⏤Ꮚࠊᶓ஭ඃ☻ ࣐ࢡࣄ࣮ࣗ㸭ࢫࣦࣛࢽ࣮ ⌧௦⢭⚄་Ꮫ ⃝᫂┘ヂ ࡳࡍࡎ᭩ᡣ 2019 ᖺ 6 ᭶－ 74 －

26. *㫽ᾏ࿴ஓ ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ ➨ 29 ᅇᏛ఍ᖺ఍࣏ࢫࢱ࣮㈹㈹グ஦
27. *ᇼෆὈỤ Ṋ⏣⛉Ꮫ᣺⯆㈈ᅋ ་Ꮫ⣔◊✲ዡບ◊✲ຓᡂ㔠ሗ࿌᭩
28. *ᇼෆὈỤ ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ ➨ 29 ᅇᏛ఍ᖺ఍࣏ࢫࢱ࣮㈹ሗ࿌᭩

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

⣒ᕝᫀᡂ ศᏊ⏕≀Ꮫ⪅ࡀぢࡓ⑓ࡢ࢖ࢽࢩ࢚࣮ࢩࣙࣥ ᪥ᮏࢹ࢖ࢣ࢔Ꮫ఍➨ 24 ᅇᖺḟ኱఍ ໭ᫍᏛᅬ኱Ꮫ 2019.9.14 ໭ᾏ㐨ᮐᖠᕷ㸦≉ูㅮ₇㸧

2.

ྜྷᕝⲁ ࢩ࣏ࣥࢪ࣒࢘ 6 ᙜ᫬⪅ࢆぶ࡟ᣢࡗࡓᏊ౪࡟ᚲせ࡞ࡶࡢ Ꮫᰯ⢭⚄ಖ೺ᩍ⫱ࡢᚲせᛶ ➨ 14 ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ 2019.4.20 ໭ᾏ㐨኱ᏛᏛ⾡஺ὶ㤋㸪໭ᾏ㐨ᮐᖠᕷࡑࡢ௚ 㸦ィ 23 ௳㸧⮬⏤ᥖ㍕
1.

*Yasue HoriuchiࠊMitsuru IshikawaࠊShin KoikeࠊNanako ObataࠊMai HatakenakaࠊSzu Yin Hsuࠊ
Kazuya ToriumiࠊMitsuhiro MiyashitaࠊYuichiro MiyaokaࠊYuki OgasawaraࠊRyoji NagaiࠊHideyuki
OkanoࠊMasanori ItokawaࠊMakoto Arai Analysis of carbonyl stress schizophrenia patient-derived
neural and glial cells ➨ 10 ᅇṊ⏣⛉Ꮫ᣺⯆㈈ᅋ⸆⛉Ꮫࢩ࣏ࣥࢪ࣒࢘ 2020.1.24㹼1.25 Ṋ⏣⸆ရ◊ಟᡤ㸪኱㜰ᗓ྿⏣ᕷ

2.

*ᇼෆὈỤࠊ▼ᕝ඘ࠊᑠᖭ⳯ࠎᏊࠊ␊୰┿౫ࠊチ⤬ⲓࠊᑠụఙࠊ㫽ᾏ࿴ஓࠊᐑୗගᘯࠊᐑᒸ
భ୍㑻ࠊᑠ➟ཎ⿱ᶞࠊᒸ㔝ᰤஅࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ ࢝ࣝ࣎ࢽࣝࢫࢺࣞࢫᛶ⤫ྜኻㄪ⑕ᝈ
⪅⏤᮶ࡢ iPS ⣽⬊ࡢゎᯒ ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 2019.10.27 ᮾ໭኱Ꮫ∦ᖹࡉࡃࡽ࣮࣍ࣝ㸪ᐑᇛ┴௝ྎᕷ

3.

*ᐑୗගᘯࠊ㕥ᮌ୍ᾈࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊྜྷᕝⲁࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ ⤫ྜኻㄪ⑕࡟࠾
ࡅࡿ AGEs ࡢ⮫ᗋⓗព⩏ ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 2019.10.27 ᮾ໭኱Ꮫ∦ᖹࡉࡃࡽ࣮࣍ࣝ㸪ᐑᇛ┴௝ྎᕷ

4.

*㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊᑠụఙࠊᐑୗගᘯࠊᇼෆὈỤࠊྜྷᕝⲁࠊᑠ➟ཎ⿱ᶞࠊ⣒ᕝᫀᡂࠊ᪂
஭ㄔ Glo1 㑇ఏᏊḞᦆ࡜ࣅࢱ࣑ࣥ B6 Ḟஈࡀ࣐࢘ࢫࡢ⢭⚄⾜ື࡟୚࠼ࡿᙳ㡪 ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 2019.10.26 ᮾ໭኱Ꮫ∦ᖹࡉࡃࡽ࣮࣍ࣝ㸪ᐑᇛ┴௝ྎᕷ

5.

*㕥ᮌ୍ᾈࠊ㫽ᾏ࿴ஓࠊᐑୗගᘯࠊᇼෆὈỤࠊྜྷᕝⲁࠊᑠụఙࠊᑠ➟ཎ⿱ᶞࠊ㮖ሯఙ௓ࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ ࣓ࢳࣝࢢࣜ࢜࢟ࢧ࣮ࣝ࡟╔┠ࡋࡓࠊ⤫ྜኻㄪ⑕ࡢ AGEs ୖ࣓᪼࢝ࢽࢬ࣒ࡢ᳨ウ ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ 2019.10.26 ᮾ໭኱Ꮫ∦ᖹࡉࡃࡽ࣮࣍ࣝ㸪ᐑᇛ┴௝ྎᕷ

6.

*Arai M. Carbonyl stress is associated with some types of schizophrenia.  21st TMIMSInternational Symposium: Overcoming neuropsychopharmacology Crisis.  2019.10.15 Tokyo
Metropolitan Institute of Medical Science, Tokyo, Japan

7.

*Masanari Itokawa Schizophrenia paradox – A material or an event - ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.13 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

8.

*Mitsuhiro MiyashitaࠊKazuya ToriumiࠊKazuhiro SuzukiࠊYasue HoriuchiࠊAkane Yoshikawaࠊ
Akiko KoboriࠊMasanari ItokawaࠊMakoto Arai Efficacy and side effect of Pyridoxamine forpatients with schizophrenia ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ－ 75 －

9.

*Kazuya ToriumiࠊKazuhiro SuzukiࠊMai AsakuraࠊMitsuhiro MiyashitaࠊYasue HoriuchiࠊAkiko
KoboriࠊMasanari ItokawaࠊMakoto Arai Vitamin B6-deficient animal model for schizophrenia
with carbonyl stress ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

10. *Kazuhiro SuzukiࠊKazuya ToriumiࠊMitsuhiro MiyashitaࠊAkane YoshikawaࠊYasue Horiuchiࠊ
Masanari ItokawaࠊMakoto Arai  Methylglyoxal in plasma associate with anxiety in healthy
individual ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
11. *Yasue HoriuchiࠊMasatoshi EgoshiࠊKazuya ToriumiࠊMitsuhiro MiyashitaࠊMasanari ItokawaࠊMakoto
Arai The utility of patients derived Neuron/glial cells for the schizophrenia disease model ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
12. *Yasue Horiuchi Progress of the International Psychiatric genetics consortium in Japan ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍㸦AsCNP2019㸧 2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
13. *ᇼෆὈỤࠊίఫె⨾ࠊᒣᕝ⿱அࠊᮾᕝᬛ⨾ࠊゅᬸᾈࠊすᮧㄔ୍㑻ࠊỈཱྀ㨱ᕫࠊ᭶ᮧ⪃ᏹࠊඡᕝᛅ㟹ࠊḈᗞᆒࠊᴋཎṇಇࠊᯇᯘᏹ⾜ࠊᒣཱྀᘓ ࢚ࢡࢯ࣮࣒ゎᯒࡢ஧ḟⓗᡤぢ⤖ᯝ㛤♧ࡀⓎ➃⪅ࠊ⾑⦕⪅ࡢ Fabry ⑓デ᩿࡟᭷ຠ࡛࠶ࡗࡓ 1 ౛ ⮫ᗋ㑇ఏ 2019 in Sapporo 2019.8.2
㹼8.4 ᮐᖠᕷᩍ⫱ᩥ໬఍㤋㸪໭ᾏ㐨ᮐᖠᕷ
14. *᪂஭ㄔ ᇶᗏ⏕ά⾜ື࡜⢾໬࣭㓟໬ࢫࢺࣞࢫࢆ㍈࡜ࡋࡓᛮ᫓ᮇ୺య౯್ᙧᡂࡢಟ㣭せᅉࡢゎ᫂ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕ⬻࣭⏕ά࣭ே⏕ࡢ⤫ྜⓗ⌮ゎ࡟ࡶ࡜࡙ࡃᛮ᫓ᮇ࠿ࡽࡢ୺య౯್
ⓎᒎᏛࠖ⌜఍㆟ 2019.7.14 ᮾி኱Ꮫ㸪ᮾி㒔ᩥி༊
15. *⣒ᕝᫀᡂ Rare Variant ࠿ࡽ㏕ࡿⓎ㐩㞀ᐖ࣭⤫ྜኻㄪ⑕ࡢデ᩿ἲ࣭἞⒪ἲࡢ㛤Ⓨ ௧࿴ඖᖺᗘ⼥ྜ⬻Ⓨ㐩㞀ᐖ࣭⤫ྜኻㄪ⑕ࢳ࣮࣒➨ 1 ᅇศ⛉఍ 2019.6.30 ࢥࣥ࣋ࣥࢩ࣮࣒ࣙࣥࣝ
AP ရᕝ㸪ᮾி㒔 ༊
16. *ᇼෆὈỤࠊ᪂஭ㄔࠊ⣒ᕝᫀᡂࠊ⃝᫂ࠊᵽཱྀ㍤ᙪ ⢭⚄⑌ᝈࢤࣀ࣒◊✲ᅜ㝿ࢥࣥࢯ࣮ࢩ࢔࣒
ࡢ㐍ᒎ≧ἣࢆ㋃ࡲ࠼࡚ ➨ 41 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍ 2019.6.23 ᮒ㮛࣓ࢵࢭ࣭᪂₲ࢢࣛࣥࢻ࣍ࢸࣝ㸪᪂₲┴᪂₲ᕷ
17. *஭ୖᬛᏊࠊᴵⴥಇ୍ࠊᐑୗගᘯࠊ㕥ᮌ୍ᾈࠊᇼෆὈỤࠊ㫽ᾏ࿴ஓࠊ⣒ᕝᫀᡂࠊᮌᮧ្ᚰࠊ
᪂஭ㄔ ࣮ࣚ࢞⒪ἲ࡟ࡼࡿ⮬ᚊ⚄⤒άືኚ໬ ➨ 115 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍
2019.6.22 ᮒ㮛࣓ࢵࢭ࣭᪂₲ࢢࣛࣥࢻ࣍ࢸࣝ㸪᪂₲┴᪂₲ᕷ
18. *ྜྷᕝⲁࠊJiang LiࠊHerber Meltzer ᶵ⬟ⓗከᆺ rs6295 ࡣᛴᛶᮇⓑே⤫ྜኻㄪ⑕࡟࠾ࡅࡿ㠀ᐃᆺᢠ⢭⚄⑓⸆ࣝࣛࢩࢻࣥࡢ἞⒪཯ᛂᛶࢆணࡍࡿ ➨ 115 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍ 2019.6.20㹼6.22 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
19. *ίఫె⨾ࠊゅᬸᾈࠊᖹᔱὈஅࠊᯇᯘᏹ⾜ࠊすᮧㄔ୍㑻ࠊᇼෆὈỤࠊᮾᕝᬛ⨾ࠊ኱▼⌶☻ࠊ㜿㒊ᑗேࠊ኱ᾉ⃈Ꮚࠊᾆୖ◊୍ࠊᴋཎṇಇࠊᒣཱྀᘓ ⭘⒆㑇ఏᏊኚ␗㔞㸦TMB㸧ࡀ㧗್࡛࠶ࡗࡓᏊᐑయ⒴⑕౛ࡢ≉ᚩ࡜ Lynch ⑕ೃ⩌ ➨ 25 ᅇ᪥ᮏᐙ᪘ᛶ⭘⒆Ꮫ఍Ꮫ⾡㞟఍
2019.6.14㹼6.15 ࢥࣥࢢࣞࢫࢡ࢚࢔᪥ᮏᶫ࣭࣋ࣝࢧ࣮ࣝᮾி᪥ᮏᶫ㸪ᮾி㒔୰ኸ༊
20. *⣒ᕝᫀᡂ ᚰࡢ࢚ࣅࢹࣥࢫ࡜ࡣఱ࠿㸫࣋ࢵࢻࢧ࢖ࢻࡢ࣮࢜ࢺࣇ࢓ࢪ࣮㸫 ➨ 17 ᅇ IGC➨ 13 ᅇ COCORO ྜྠ఍㆟ 2019.6.2 ࣇࢡࣛࢩ࢔ရᕝ㸪ᮾி㒔ရᕝ༊
21. *ᇼෆὈỤࠊίఫె⨾ࠊᯇᯘᏹ⾜ 㟼ᒸࡀࢇࢭࣥࢱ࣮ࣉࣟࢪ࢙ࢡࢺ HOPE ࡟࠾ࡅࡿ஧ḟⓗᡤぢ࡜ࡑࡢᑐᛂ ➨ 105 ᅇ᪥ᮏᾘ໬ჾ⑓Ꮫ఍⥲఍ 2019.5.9㹼5.11 ANA ࢡࣛ࢘ࣥࣉࣛࢨ
࣍ࢸࣝ㔠ἑ㸪▼ᕝ┴㔠ἑᕷ

－ 76 －

22. *ᐑୗගᘯ ⤫ྜኻㄪ⑕࡟࠾ࡅࡿࣅࢱ࣑ࣥ B6 ⿵඘⒪ἲࡢຠᯝ 㹼ᮾி㒔❧ᯇἑ⑓㝔࡟࠾ࡅࡿ་ᖌ୺ᑟᆺ἞㦂ࡢሗ࿌㹼 TOBIRA ➨ 8 ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ 2019.5.10 ࢯࣛࢩࢸ࢕࢝
ࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮ ࢯࣛࢩࢸ࢕࣮࣍ࣝ㸪ᮾி㒔༓௦⏣༊
23. *⣒ᕝᫀᡂ ᙜ஦⪅ࢆぶ࡟ᣢࡗࡓᏊ౪࡟ᚲせ࡞ࡶࡢ㹼ᶆ‽໬ࢆ㉸࠼࡚㹼 ➨ 14 ᅇ᪥ᮏ⤫ྜኻㄪ⑕Ꮫ఍ 2019.4.19㹼4.20 ໭ᾏ㐨኱ᏛᏛ⾡஺ὶ㤋㸪໭ᾏ㐨ᮐᖠᕷ
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 45 ௳㸧
1.

ᐑୗගᘯ. ㄆ▱⑕ࢆ▱ࢁ࠺㸟 㹼ᇶ♏▱㆑࠿ࡽ἞⒪࣭ࢣ࢔࣭ண㜵ࡲ࡛㹼 ᫛ᓥᕷ♫఍⚟♴༠㆟఍ㅮ₇఍ 2020.2.18 ᮾி㒔᫛ᓥᕷ2.

ᐑୗගᘯ. ⤫ྜኻㄪ⑕࡟ࡘ࠸࡚ 㹼デᐹ⌧ሙࡢ㞧ឤࢆྵࡵ࡚㹼 2019 ᖺᗘ᫛ᓥᕷᆅᇦᨭ
᥼༠㆟఍ ┦ㄯᨭ᥼㒊఍Ꮫ⩦఍ 2020.1.24 ᮾி㒔᫛ᓥᕷ

3.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⸆≀౫Ꮡࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2020.1.20 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊

4.

ᇼෆὈỤ ศᏊ⚄⤒Ꮫࠕᝈ⪅⏤᮶ࢧࣥࣉࣝࢆ⏝࠸ࡓ⢭⚄⑌ᝈ⑓ែ◊✲ࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2020.1.6 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊

5.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⤫ྜኻㄪ⑕ࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.12.16 ❧ᩍ኱Ꮫ㸪ᮾி
㒔㇏ᓥ༊

6.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ᝟ື࣭ࢫࢺࣞࢫࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.12.9 ❧ᩍ኱Ꮫ㸪ᮾ
ி㒔㇏ᓥ༊

7.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ㐠ືࡢไᚚ࣭⚄⤒ኚᛶ⑌ᝈࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.12.2 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊

8.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕࡑࡢ௚ࡢឤぬࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.11.25 ❧ᩍ኱Ꮫ㸪ᮾி
㒔㇏ᓥ༊

9.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕどぬࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.11.18 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊

10. 㫽ᾏ࿴ஓ ศᏊ⚄⤒ᏛࠕᏛ⩦࡜グ᠈ࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.11.11 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊
11. ᐑୗගᘯ ㄆ▱⑕࡟ࡘ࠸࡚ࠊ㹼ᇶ♏▱㆑࠿ࡽ἞⒪࣭ࢣ࢔࣭ண㜵ࡲ࡛㹼 ᖹᡂ 31 ᖺᗘ᫛ᓥᕷ࣭
ㄆ▱⑕࡟㛵ࡍࡿᕷẸྥࡅㅮ₇఍ 2019.11.9 ᮾி㒔᫛ᓥᕷ12. 㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⚄⤒Ⓨ⏕ࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.10.28 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊
13. ⣒ᕝᫀᡂ ᚰࡢᒙᵓ㐀 [ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.10.23 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
14. ᪂஭ㄔ ⢭⚄⑌ᝈࡢ⑓ᅉゎ᫂࡜⑓ែ⌮ゎ㸫⢭⚄⑌ᝈࡢ⌧≧࡜ၥ㢟Ⅼ࡟ࡘ࠸࡚ ❧ᩍ኱Ꮫ⏕࿨⌮Ꮫ≉ูㅮ⩏ 2019.10.21 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊15. ᪂஭ㄔ ⚄⑌ᝈࡢ⑓ᅉゎ᫂࡜⑓ែ⌮-⤫ྜኻㄪ⑕ࡢ⑓ែゎ᫂࡟ྥࡅࡓྲྀࡾ⤌ࡳ ❧ᩍ኱Ꮫ⏕࿨⌮Ꮫ≉ูㅮ⩏ 2019.10.21 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊
16. 㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⚄⤒ఏ㐩≀㉁Ϩ࣭ϩࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.10.14ࠊ10.21 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊17. ᪂஭ㄔ ⤫ྜኻㄪ⑕◊✲ࡢᇶ♏࡜⮫ᗋࡢࢡࣟࢫࢺ࣮ࢡ ᮾி㒔❧ᯇἑ⑓㝔⢭⚄⛉་ᒁࢭ࣑ࢼ࣮ 2019.10.8 ᯇἑ⑓㝔㸪ᮾி㒔ୡ⏣㇂༊
18. ᐑୗගᘯ ་⒪࠿ࡽぢࡓ௓ㆤ࡟ࡘ࠸࡚ ᫛ᓥᕷㅮ₇఍ 2019.10.7 ᫛ᓥᕷㄆ▱⑕࢝ࣇ࢙ࠕ࢜ࣞࣥࢪࢻ࢔ࠖ
㸪ᮾி㒔᫛ᓥᕷ

－ 77 －

19. 㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⚄⤒ఏ㐩ࡢ௙⤌ࡳࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.10.7 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊
20. ⣒ᕝᫀᡂ ᐙ᪘࡬ࡢᛮ࠸࡜୕ே࡜ࡢฟ఍࠸࠿ࡽఏ࠼ࡓ࠸ࡇ࡜ ࡦࡻ࠺࠿ࢀࢇ๰❧ 50 ࿘ᖺグᛕ኱఍ࢺ࣮ࢡࣛ࢖ࣈ 2019.10.5 රᗜ┴┳ㆤ༠఍ 2 㝵ࣁ࣮ࣔࢽ࣮࣮࣍ࣝ㸪රᗜ┴⚄ᡞᕷ21. ⣒ᕝᫀᡂ ேࡣ࡞ࡐ⑓ࢆᚓࡿࡢ࠿㸫≀㉁࡜≀㉁࡛࡞࠸ࡶࡢࡢ⛉Ꮫ㸦⤫ྜኻㄪ⑕ࢆ୰ᚰ࡟㸧௧࿴ඖᖺᗘ㮵⢭༠๓ᮇ㝔㛗➼◊ಟ఍ 2019.9.25 ᇛᒣ࣍ࢸࣝ㮵ඣᓥ㸪㮵ඣᓥ┴㮵ඣᓥᕷ22. 㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⚄⤒⣔ࡢᡂࡾ❧ࡕ࣭⚄⤒⣔ࡢ⣽⬊࡜ᵓ㐀ࠖࠕᤵᴗᴫせࠖ ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2019.9.23ࠊ9.30 ❧ᩍ኱Ꮫ㸪ᮾி㒔㇏ᓥ༊23. ⣒ᕝᫀᡂ ⬻௨እࡢᚰ[ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.9.18 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
24. ᐑୗගᘯ ㄆ▱⑕࡜㛫㐪࠸ࡸࡍ࠸ࡇࡇࢁࡢ⑓Ẽ ᫛ᓥᕷㅮ₇఍ 2019.9.13 ᫛ᓥᕷᙺᡤ㸪ᮾி㒔᫛ᓥᕷ
25. ⣒ᕝᫀᡂ ࡇ ࡇ ࢁ ࡢ ⚄ ⤒ ⛉ Ꮫ 㸫 ே ࡢ 㐍 ໬ ࡜⏕Ꮡ ᡓ ␎ 㸫  ኱ ศ ኱ Ꮫ་Ꮫ 㒊 ≉ ู ㅮ ₇
2019.9.6 ኱ศ኱Ꮫ㸪኱ศ┴኱ศᕷ
26. ⣒ᕝᫀᡂ ᚰࡢ㉳※㸫⢭⚄㞀☀࡜ࡣ࡝࠺࠸࠺ࡇ࡜࠿㸫 ᯇἑ⑓㝔ࣞࢪࢹࣥࢺࢡࣝࢬࢫ
2019.9.3 ᯇἑ⑓㝔㸪ᮾி㒔ୡ⏣㇂༊
27. ⣒ᕝᫀᡂ Ẽᣢࡕࡼ࠸ࡇ࡜࡜⮬↛἞⒵ຊ[ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.8.28 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊28. ⣒ᕝᫀᡂ ೔⌮ⓗࡩࡿࡲ࠸࡜ࡣఱ࠿[ㅮ₇] 㥖㎸⑓㝔೔⌮◊ಟ 2019.8.21 㥖㎸⑓㝔㸪ᮾி㒔
29. ⣒ᕝᫀᡂ ᚰࡢ⑓࡜ࡣఱ࠿㹼≀㉁࡜≀㉁࡛࡞࠸ࡶࡢ㹼 ኱ᐙ㐃⢭⚄ಖ೺⚟♴ㅮᗙճ
2019.8.3 ࢚ࣝ࠾࠾ࡉ࠿㸪኱㜰ᗓ኱㜰ᕷ
30. ᪂஭ㄔ ⏕࿨⛉Ꮫ◊✲⪅࡜࠸࠺ᑗ᮶࡟ྥࡅࡓṌࡳࡸࡾࡀ࠸ࡢ࠶ࡿ௙஦ࡗ࡚㸽 㧗ᰯ⏕ࡢࡓࡵࡢ㒔་Ꮫ◊ࣇ࢛࣮࣒ࣛ 2019.8.1 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
31. ⣒ᕝᫀᡂ ⬻࡜ᚰ[ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.7.24 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
32. ᪂஭ㄔ ⏕ά⩦័࡜⢾໬࣭㓟໬ࢫࢺࣞࢫࡢ┦஫స⏝ࡀ୺య౯್ࡢᙧᡂ࡜ᨵ⦅࡟୚࠼ࡿᙳ㡪᪂Ꮫ⾡㡿ᇦ◊✲ ⬻࣭⏕ά࣭ே⏕࠿ࡽࡢ⥲ྜⓗ⌮ゎ࡟ࡶ࡜࡙ࡃᛮ᫓ᮇ࠿ࡽࡢ୺య౯್ⓎᒎᏛ Newsletter, vol. 3, July, 201933. ⣒ᕝᫀᡂ ⢭⚄⛉࡛ാࡃࡇ࡜㸫࠸࠿࡟࡜ࡽ࠼ࠊ࠸࠿࡟㐺࠼ࡿ࠿㸫[ㅮ₇] ㏥㝔‽ഛㅮᗙ
2019.7.12 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
34. ⣒ᕝᫀᡂ ᚰࡣ࡝ࢀࡃࡽ࠸⬻࡞ࡢ࠿㸫ศᏊ⏕≀Ꮫࡀㄒࡿᚰࡢ㐍໬࣭⢭⚄ࡢ⛉Ꮫ㸫 ᮾி኱Ꮫᩍ㣴Ꮫ㒊 2019 ᖺᗘ S ࢭ࣓ࢫࢱ࣮࣭඲Ꮫయ㦂ࢮ࣑ࢼ࣮ࣝ 2019.7.7 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
35. ⣒ᕝᫀᡂ ⤫ྜኻㄪ⑕ࡢ⌮ゎ࡜ᑐᛂ㹼ᐙ᪘ࡢࢃࡓࡋࡓࡕࡀ࡛ࡁࡿࡇ࡜㹼 ࡇࡇࢁࡢ೺ᗣ
࡙ࡃࡾㅮ₇఍ 2019.6.28 ⋢ᕝ༊Ẹ఍㤋㸪ᮾி㒔ୡ⏣㇂༊
36. ⣒ᕝᫀᡂ 㒔❧⑓㝔࡟࠾ࡅࡿ་ᖌ୺ᑟ἞㦂 ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮࣭ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤඹദ ⮫ᗋ◊✲ࢭ࣑ࢼ࣮ 2019.6.27 ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮㸪ᮾி㒔ᗓ୰ᕷ37. ⣒ᕝᫀᡂ ⢭⚄⛉࡛ാࡃࡇ࡜㸫࠸࠿࡟࡜ࡽ࠼ࠊ࠸࠿࡟㐺࠼ࡿ࠿㸫[ㅮ₇] On-the-Job Training2019.6.17 ᯇἑ⑓㝔 53 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
38. ⣒ᕝᫀᡂ ᜏᖖᛶࡢ⥔ᣢ㸫Ẽᣢࡕ࠸࠸࡜ឤࡌࡿࡇ࡜㸫[ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.5.22 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
39. ⣒ᕝᫀᡂ ⮫ᗋᐙࡀ◊✲ࢆࡍࡿ⌮⏤㸫ศᏊ⏕≀Ꮫ⪅ࡀࡳࡓᚰࡢ་Ꮫ㸫 ᇸ⋢་⛉኱Ꮫ་Ꮫ㒊࣭⚄⤒⛉Ꮫࢭ࣑ࢼ࣮ 2019.5.20 ᇸ⋢་⛉኱Ꮫ࢜ࣝࢥࢫ࣮࣍ࣝ㸪ᇸ⋢┴ධ㛫㒆－ 78 －

40. ⣒ᕝᫀᡂ ༞ᴗ⏕ࡀ࡞ࡐ◊✲⏕άࢆ㑅ࢇࡔࡢ࠿ ᇸ⋢་⛉኱Ꮫ་Ꮫ㒊࣭㑅ᢥᚲಟㅮ⩏
2019.5.20 ᇸ⋢་⛉኱Ꮫ㸪ᇸ⋢ධ㛫㒆
41. ⣒ᕝᫀᡂ ࡦ࡜ࡣ࡞ࡐᚰࢆ⑓ࡴࡢ࠿㸫⬻ࢆ 30 ᖺ◊✲ࡋ࡚ࡳ࡚㸫 ቚᮾ⑓㝔⚄⤒⛉㞟ㄯ఍
2019.5.16 㒔❧ቚᮾ⑓㝔㸪ᮾி㒔ቚ⏣༊
42. ᐑୗගᘯ ⢭⚄⑌ᝈ࡜ࡑࡢ἞⒪ձղճ ୖᬛ♫఍⚟♴ᑓ㛛Ꮫᰯ⢭⚄ಖ೺⚟♴ኈ㏻ಙㄢ⛬ㅮ⩏ 2019.4.6ࠊ4.13ࠊ4.27 ୖᬛ♫఍⚟♴ᑙ㛛Ꮫᰯ㸪ᮾி㒔༓௦⏣༊
43. ⣒ᕝᫀᡂ ࣄࢺࡣ࡞ࡐᚰࢆ⑓ࡴࡢ࠿㸫ศᏊ⏕≀Ꮫࡀᣮࡴ⢭⚄ࡢ⛉Ꮫ㸫 ᮾி኱Ꮫ኱Ꮫ㝔᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉࣓ࢹ࢕࢝ࣝ᝟ሗ⏕࿨ㅮ⩏ 2019.5.10 ᮾி኱Ꮫ་⛉Ꮫ◊✲ᡤ㸪ᮾி㒔༊

44. ⣒ᕝᫀᡂ ⑓࡜≀ㄒ[ㅮ₇] ㏥㝔‽ഛㅮᗙ 2019.4.24 ᯇἑ⑓㝔 54 ⑓Ჷ㸪ᮾி㒔ୡ⏣㇂༊
45. ᇼෆὈỤ ࡑࡶࡑࡶ㑇ఏ࡜ࡣఱ࠿ 㟼ᒸࡀࢇࢭࣥࢱ࣮ᝈ⪅ࢧࣟࣥ 2019.4.9 㟼ᒸࡀࢇࢭࣥࢱ࣮㸪㟼ᒸ┴㥴ᮾ㒆IV. ≉グ஦㡯
࠙ཷ㈹ࠚ
1.

ᇼෆὈỤ ࣏ࢫࢱ࣮㈹ ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ᖺ఍ 2019.10.27

2.

㫽ᾏ࿴ஓ ࣏ࢫࢱ࣮㈹ ➨ 29 ᅇ᪥ᮏ࣓࢖࣮ࣛࢻᏛ఍ᖺ఍ 2019.10.27

3.

ᑠᖭ⳯ࠎᏊࠊ㔝ཎἨ ᖹᡂ 31 ᖺᗘ⛉Ꮫᢏ⾡ศ㔝ᩥ㒊⛉Ꮫ኱⮧⾲ᙲ ๰ពᕤኵຌປ⪅㈹ 2019.4.9࠙㒔❧Ꮫᰯ࡟࠾ࡅࡿ⢭⚄⛉ᑓ㛛་ὴ㐵஦ᴗࠚ
1㸬ྜྷᕝⲁ ᮾி㒔❧⏫⏣㧗➼Ꮫᰯ 2019.9.18

－ 79 －

ࣉࣟࢪ࢙ࢡࢺྡ

࠺ࡘ⑓ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

*Uemura T, Mochida M, Matsumi T, Yoshimoto K, Tatebayashi Y (2019) Therapy-refractoryschizophrenia in a patient who previously suffered from Meige’s syndrome. Neuropsychipharma
Rep https://doi.org/10.1002/npr2.12081.

2.

*Bauer R㸦௨ୗ92ே␎㸧, Tatebayashi Y, (11ே␎) (2019) Association between solar insolation
and a history of suicide attempts in bipolar I disorder. J Psychiatr Res 113:1-9.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧
1.

⳥ụ㸦஧ᮏᯇ㸧ᑦ⨾ࠊ*ᴙᯘ⩏Ꮥ ࠙ാࡃ⣽⬊㸦࣓ࣥࢱࣝ⦅㸧ࠚ࢜ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࡜⢭⚄⑌ᝈ. ⢭⚄⛉ 35: 355-361.

2.

*ᴙᯘ⩏Ꮥ (2019)࠙ㄆ▱⑕ࢆ⪃࠼ࡿࠚ࠺ࡘ⑓࡜ㄆ▱⑕㸦ゎㄝ/≉㞟㸧 ⢭⚄⛉ 34: 346-351

3.

⳥ụ㸦஧ᮏᯇ㸧ᑦ⨾ࠊ*ᴙᯘ⩏Ꮥ ࠙㧗㱋⪅ࡢ⢭⚄⑌ᝈ(ㄆ▱⑕ࢆ㝖ࡃ)ࠚ࠺ࡘ⑓࠿ࡽㄆ▱⑕࡬ࡢ⛣⾜ࡢ࣓࢝ࢽࢬ࣒㸦ゎㄝ/≉㞟㸧. Geriatric Medicine 57: 247-251.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

*Tatebayashi Y, Kikuchi-Nihonmatsu N, Matsuda Y, Aoki K, Uchihara T (2019) Further evidence for the
essential involvement of plexin-B3+ oligodendrocyte progenitor cells in the pathogenesis of Alzheimer's
disease. Alzheimer’s Association International Conference in Sydney, 2019.9.22, Sydney, Australia

2.

*ᴙᯘ⩏Ꮥࠊ࢜ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࠿ࡽぢࡓࠊ࢔ࣝࢶࣁ࢖࣐࣮࣭࢔࣑ࣟ࢖ࢻ௬ㄝࡢၥ㢟Ⅼ ➨30 ᅇከᦶ࢟ࣕࣥࣃࢫ⚄⤒࢝ࣥࣇ࢓ࣞࣥࢫ 2019.9.13 ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮㸪ᮾி㒔ከᦶᕷ3.

ᯇ⏣ⰾᶞࠊ*ᴙᯘ⩏Ꮥࠊ᪂ࡋ࠸ࣛࢵࢺ࠺ࡘ⑓ࣔࢹࣝࡢゎᯒ ➨6 ᅇࢧ࢖ࢥࢢࣜ࢔◊✲఍ 2019.5.25 ᒾᡭ┴4.

*ᴙᯘ⩏Ꮥ ࠺ࡘ⑓⏕≀Ꮫⓗ◊✲ࡢ⌧≧ ╧╀࣭⅖⑕ࢆ୰ᚰ࡟ ➨ 12 ᅇ༡ಙᕞ῱ὶࣇ࢛࣮
࣒ࣛ in 㣤⏣ 2019.4.20 㣤⏣⑓㝔㸪㛗㔝┴㣤⏣ᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯1.

ᴙᯘ⩏Ꮥ ᩥ໬ᨺ㏦ࣛࢪ࢜ࠕࣁ࣮ࢺࣜࣥࢢ೺ᗣ RADIOࠖฟ₇ 2019.8.4ࠊ8. 11ࠊ8.18－ 80 －

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1HXUR  ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ ᮏከ┿ ࢼࣝࢥࣞࣉࢩ࣮࡜⫧‶ ᪥ᮏ╧╀Ꮫ఍➨  ᅇᐃᮇᏛ⾡㞟఍  ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ᡂ⃝ඖࠊఀᮾⱝᏊࠊᮌᮧ┾ஓࠊబࠎᮌ࠿࠾ࡾࠊ࿴⏣ ┿ᏕࠊᏳṇ㙞ࠊ㧗ᶫᩄ἞ࠊᮏከ┿ ୺ほⓗ╀Ẽ࡜ᐈほⓗ╀Ẽࡢ஋㞳ࡍࡿ⪅࡟ࡳࡽࢀࡿ╧╀࡜ᚰ㌟ࡢ≉ᚩ ᪥ᮏ╧╀Ꮫ఍➨  ᅇᐃᮇᏛ⾡㞟఍  ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ᮌᮧ┾ஓࠊబࠎᮌ࠿࠾ࡾࠊ࿴⏣┿Ꮥࠊୖ㔝ኴ㑻ࠊఀᮾⱝᏊࠊᮏከ┿ ,+6 デ᩿࡟ᑐࡍࡿ㛗᫬㛫╧╀ホ౯ࡢ᭷⏝ᛶࡢ᳨ウ ᪥ᮏ╧╀Ꮫ఍➨  ᅇᐃᮇᏛ⾡㞟఍  ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ⩚⃈ᜨࠊఀᮾⱝᏊࠊ࿴⏣┿Ꮥࠊᮏከ┿ ୰ᯡ㐣╀⑕࡟࠾ࡅࡿ἞⒪᭷↓࡟క࠺ᚰ⌮♫఍ⓗഃ㠃ࡢ┦㐪 ᪥ᮏ╧╀Ꮫ఍➨  ᅇᐃᮇᏛ⾡㞟఍  ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ᕝᔱ┿⣖Ꮚࠊୖ㔝ኴ㑻ࠊఀᮾⱝᏊࠊ⏣ᕝᮥ㑣ࠊᮏከ┿ ᝟ື⬺ຊⓎసࢆక࠺ࢼࣝࢥࣞࣉࢩ࣮
࡟࠾ࡅࡿᛶ᱁≉ᚩ㸫࣮ࣟࣝࢩࣕࢵࣁࢸࢫࢺ࡟ࡼࡿ᳨ウ㸫 ᪥ᮏ╧╀Ꮫ఍➨  ᅇᐃᮇᏛ⾡－ 82 －

㞟఍  ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ᮏከ┿  ᫬㛫36* ࢆ⏝࠸ࡓ⑓ⓗ㐣╀ࡢุᐃ ᪥ᮏ╧╀Ꮫ఍➨ ᅇᐃᮇᏛ⾡㞟఍ ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ ᐑᕝ༟ 㐣╀⑕ࡢ㑇ఏせᅉ࡜ +/$ࡢព⩏ ᪥ᮏ╧╀Ꮫ఍➨ ᅇᐃᮇᏛ⾡㞟఍ 
㹼 ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷᔱከ⨾✑Ꮚࠊᐑᕝ༟ࠊᚨỌ຾ኈࠊᮏከ┿ ᚋ㒊どᗋୗ㒊࡜ഃ㢌ⴥ⓶㉁ࢧࣥࣉࣝࢆ⏝࠸ࡓࢼࣝࢥࣞࣉࢩ࣮࡟㛵㐃ࡍࡿ'1$ ࣓ࢳࣝ໬ࡢ᥈⣴ ᪥ᮏ╧╀Ꮫ఍➨ ᅇᐃᮇᏛ⾡㞟఍ ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ 0L\DJDZD7$YDULDQWDIIHFWLQJOHYHOVRIVXFFLQ\OFDUQLWLQHLVDVVRFLDWHGZLWK+/$'4% QHJDWLYHHVVHQWLDOK\SHUVRPQLD ᅜ㝿ࢤࣀ࣒఍㆟ 㹼 ᮾி
 +RQGD0ࠊ:,WR 06/7$1'KU36*IRU'LDJQRVLQJ,GLRSDWKLF+\SHUVRPQLD  UG0HHWLQJ
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఍ㅮ₇఍  ᾆᏳᕷ௒ᕝグᛕ఍㤋㸪༓ⴥ┴ᾆᏳᕷᮏከ┿ ╧╀㞀ᐖ࡜⮬ື㌴㐠㌿㹙ㅮ⩏㹛 ௧࿴ඖᖺᗘ㐠㌿㐺ᛶ┦ㄯᑓ⛉ࠊ 㛵ᮾ⟶༊㆙ᐹᏛᰯ㸪ᮾி㒔ᑠᖹᕷᮏከ┿ ╀Ẽࡢࡋࡃࡳ࡜ࡑࡢᑐฎἲࠕ╧╀࡜ᚰࡢ㛵ಀࠖ㹙ㅮ₇㹛  ᖺᗘ➨  ᅇ㒔Ẹㅮᗙ  ࢽࢵࢩ࣮࣮ࣙ࣍ࣝ㸪ᮾி㒔༊ᮏከ┿ ࡡࡴࡾࡢࡋࡃࡳ 㹙ㅮ⩏࡜ᐇ⩦㹛  ➨  ᅇࢧ࢖࢚ࣥࢫ࢝ࣇ࢙  ་Ꮫ◊ 㝵ㅮᇽ㸪ᮾி㒔ୡ⏣㇂༊ᮏከ┿ ᝈ⪅ࢆ⏕ࡁࡿ ࢼࣝࢥࣞࣉࢩ࣮㹙ྲྀᮦ㹛 ᮅ᪥᪂⪺ 㹼ᮏከ┿ ╀ࡾࡢ௙⤌ࡳ࡜ࡼ࠸╀ࡾࡢᕤኵ 㹙ㅮ⩏㹛 ࠾ⲔࡢỈዪᏊ኱Ꮫ㝃ᒓ㧗ᰯ◊✲ᡤぢᏛ ་Ꮫ◊఍㆟ᐊ &㸪ᮾி㒔ୡ⏣㇂༊,9 ≉グ஦㡯ᮏከ┿ ,&'&KDSWHU 6OHHS:DNH'LVRUGHUV  సᡂ LQWHUQDWLRQDOERDUGPHPEHU 㸦⡿ᅜ╧╀
Ꮫ఍ 6DWHLD ᩍᤵጤဨ㛗㸧ᮏከ┿ ཌ⏕ປാ┬ᅜ㝿ศ㢮᝟ሗ⟶⌮ᐊ ⑌⑓ࠊയᐖ࠾ࡼࡧṚᅉศ㢮ᑓ㛛ጤဨ఍ጤဨ

㸦⌧ᅾ㸧ᮏከ┿ ᝈ⪅ࢆ⏕ࡁࡿ ࢼࣝࢥࣞࣉࢩ࣮ ᮅ᪥᪂⪺ 㹼㸦ࢥ࣓ࣥࢺグ㍕㸧ᮏከ┿ ࢨ㸟ୡ⏺௮ኳࢽ࣮ࣗࢫ ࢼࣝࢥࣞࣉࢩ࣮ ᪥ᮏࢸࣞࣅ 㸦ฟ₇࡜┘ಟ㸧－ 83 －

ࣉࣟࢪ࢙ࢡࢺྡ

౫Ꮡᛶ⸆≀ࣉࣟࢪ࢙ࢡࢺ

, ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ  ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
 1LQDJDZD- 6XPLWDQL01LVKL]DZD'1DJDVKLPD00LHWDQL.$EH+,QRXH5+R]XPL-
7VXFKLGD5,NHGD.<DPDGD<  $GLSRQHFWLQUHFHSWRUJHQHLVSRWHQWLDOO\DVVRFLDWHGZLWKVHYHULW\ RI SRVWRSHUDWLYH SDLQ EXW QRW FDQFHU SDLQ Medicine   H GRL0' .RWDMLPD0XUDNDPL +7DNDQR $ 2JDL < 7VXNDPRWR 6 0XUDNDPL 0 )XQDGD '7DQLEXFKL<
7DFKLPRUL+0DUXR.6DVDNL70DWVXPRWR7 ,NHGD.  6WXG\RIHIIHFWVRILIHQSURGLOLQ
SDWLHQWV ZLWK PHWKDPSKHWDPLQH GHSHQGHQFH 3URWRFRO IRU DQ H[SORUDWRU\ UDQGRPL]HGGRXEOHEOLQG SODFHERFRQWUROOHG WULDO Neuropsychopharmacol

Rep    GRLQSU )XMLWD0,GH6 ,NHGD.  2SLRLG DQG QRQGRSDPLQH UHZDUGFLUFXLWU\DQGVWDWHGHSHQGHQWPHFKDQLVPVAnn NY Acad Sci   GRLQ\DV
 ,GH6,NHNXER<0LVKLQD0+DVKLPRWR. ,NHGD.  &RJQLWLYHLPSDLUPHQWWKDWLVLQGXFHGE\ R NHWDPLQH LV DEROLVKHG LQ 10'$ *OX1' UHFHSWRU VXEXQLW NQRFNRXW PLFH Int J
NeuropsychopharmacolGRLLMQSS\]
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 ,GH6,NHGD.  'LVWLQFWUROHVRI10'$UHFHSWRU*OX1VXEXQLWVLQWKHHIIHFWVRINHWDPLQH
DQG LWV HQDQWLRPHUV ,Q .HWDPLQH +DVKLPRWR . ,GH 6 ,NHGD . (GV  SS 6LQJDSRUH
6SULQJHU6LQJDSRUH ᰝㄞ↓ GRLB +DVKLPRWR.,GH6,NHGD. (GV   .HWDPLQH6LQJDSRUH6SULQJHU6LQJDSRUH ➟஭ៅஓࠊ
ụ⏣࿴㝯   ➨  ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍ ⢭⚄⛉⮫ᗋ Legato   ஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯   ࢔ࢹ࢕ࢡࢩࣙࣥࡢ໬Ꮫ ⌧௦໬Ꮫ 
 す⃝኱㍜ࠊ ụ⏣࿴㝯 ⸆≀ឤཷᛶࡢศᏊ⏕≀Ꮫⓗᇶ♏ ,Q ࢔ࢹ࢕ࢡࢩࣙࣥࢧ࢖࢚ࣥࢫ㸫౫Ꮡ࣭
ႴⒷࡢ⛉Ꮫ㸫 㸦ᐑ⏣ஂႹ࣭㧗⏣Ꮥ஧࣭ụ⏣࿴㝯࣭ᘅ୰┤⾜ ⦅ⴭ㸧 SS ᮾி ᮅ಴᭩ᗑ ᐑ⏣ஂႹࠊ㧗⏣Ꮥ஧ࠊụ⏣࿴㝯ࠊᘅ୰┤⾜ 㸦⦅ⴭ㸧 ࢔ࢹ࢕ࢡࢩࣙࣥࢧ࢖࢚ࣥࢫ㸫౫Ꮡ࣭
ႴⒷࡢ⛉Ꮫ㸫 ᮾி ᮅ಴᭩ᗑ
,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧,GH6,NHGD. 7KHUROHRI10'$UHFHSWRU*OX1'VXEXQLWLQWKHHIIHFWVRINHWDPLQHDQGLWV
HQDQWLRPHUV  WK &RQJUHVV RI $VLDQ &ROOHJH RI 1HXURSV\FKRSKDUPDFRORJ\ $V&13  ⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ㸤࣮࣍ࣝ㸪⚟ᒸ┴⚟ᒸᕷ－ 84 －

2.

*Ide S, Ikeda K Usefulness of intracranial self-stimulation mmethod in drug dependence
research.  6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ3.

*す⃝኱㍜ࠊụ⏣࿴㝯 ᵝࠎ࡞౫Ꮡᛶ≀㉁ࡢឤཷᛶ࡟ඹ㏻ࡋ࡚ᐤ୚ࡍࡿ㑇ఏᏊከᆺ 2019ᖺᗘ࢔ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍ 2019.10.6 ᮐᖠࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ
࣮㸪໭ᾏ㐨ᮐᖠᕷ

4.

*ụ⏣࿴㝯 ᣑ኱ࡍࡿ࢔ࢹ࢕ࢡࢩࣙࣥၥ㢟࡬࢔࢝ࢹ࣑࢔ࡣ࡝࠺ྲྀࡾ⤌ࡴ࠿ 2019 ᖺᗘ࢔ࣝࢥ࣮
࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍ 2019.10.5 ᮐᖠࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸪໭ᾏ㐨ᮐᖠᕷ

5.

*Ikeda K, Nishizawa D, Hayashida M, Fukuda K Personalized opioid use for controlling painand drug abuse The 10th IBRO World Congress of Neuroscience6.

2019.9.22 EXCO㸪Korea*ụ⏣࿴㝯ࠊす⃝኱㍜ࠊ஭㛵㞞Ꮚࠊᯘ⏣┾࿴ࠊ⚟⏣ㅬ୍ ⮫ᗋ࡟ࡘ࡞ࡀࡿ㑇ఏᏊ◊✲࢔ࢵࣉࢹ࣮ࢺ ➨ 39 ᅇ㙠③⸆࣭࢜ࣆ࢜࢖ࢻ࣌ࣉࢳࢻࢩ࣏ࣥࢪ࣒࢘ 2019.8.24 㡰ኳᇽ኱Ꮫ኱
Ꮫ㝔་Ꮫ㒊㸪ᮾி㒔ᩥி༊7.

*ụ⏣࿴㝯ࠊྂ⏣ᓥᾈᏊࠊ⏣୰⨾Ṍࠊ᯽஭ὒᩥࠊబ⸨ᩔᚿ ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖࡢື≀ࣔࢹࣝసᡂ࡜ゎᯒ ➨ 140 ᅇ᪥ᮏ⸆⌮Ꮫ఍㛵ᮾ㒊఍ 2019.7.6 ᫍ⸆⛉኱Ꮫ ᪂ᫍ㤋&ⓒᖺ
グᛕ㤋㸪ᮾி㒔ရᕝ༊8.

*ụ⏣࿴㝯 ᛌ࣭୙ᛌ᝟ື࡜⑊③ไᚚ࡟㛵ࢃࡿศᏊ⩌ ➨ 41 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍
2019.6.23 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

9.

*Ikeda K, Ide S Involvement of NMDA receptor GluN2D subunit in ketamine effects 14th
World ongress of Biological Psychiatry (WFSBP Congress 2019)  2019.6.6  Vancouver
Convention Centre, Vancouver, Canada

10. *ụ⏣࿴㝯 ౫Ꮡ⑕࡟ᑐࡍࡿ⦆࿴་⒪⸆Ꮫ ➨ 13 ᅇ᪥ᮏ⦆࿴་⒪⸆Ꮫ఍ᖺ఍ 2019.6.1
ᖥᙇ࣓ࢵࢭ㸪༓ⴥ┴༓ⴥᕷࡑࡢ௚ 㸦ィ 26 ௳㸧⮬⏤ᥖ㍕
1.

*஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯 ື≀ࣔࢹࣝ࡟࠾ࡅࡿ౫Ꮡᛶホ౯ ➨ 93 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍2020.3.16㹼3.18 ⣬ୖ㛤ദ2.

*᳃ᒇ⏤⣖ࠊす⃝኱㍜ࠊ஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯 ࣓ࢱࣥࣇ࢙ࢱ࣑ࣥ࡟ࡼࡿ⾜ືឤసᙧᡂ࡟࠾
ࡅࡿ࢜ࣆ࢜࢖ࢻࢩࢫࢸ࣒ࡢᶵ⬟ゎᯒ 2019 ᖺᗘ᪂Ꮫ⾡㡿ᇦ◊✲ Ꮫ⾡◊✲ᨭ᥼ᇶ┙ᙧᡂ࣭ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ᡂᯝⓎ⾲఍ 2020.2.5 ⍇⍈†࣍ࢸࣝ㸪⁠㈡┴኱ὠᕷ

3.

*す⃝኱㍜ࠊ᭷⏣ⱥᏊࠊⰼᒸ୍㞝ࠊ▮ᓥ┤ࠊ஭㛵㞞Ꮚࠊຍ⸨ᐇࠊᑠᕝ⠇㑻ࠊᖹ἟ᙬᏊࠊ➟஭ៅஓࠊ㛗㇂ᕝ‽ᏊࠊỤ⏿⿱Ꮚࠊ୰ᒣிᏊࠊᯘ⏣┾࿴ࠊụ⏣࿴㝯 ࢤࣀ࣒࣡࢖ࢻ㛵㐃ゎᯒ
㸦GWAS㸧࡟ࡼࡿ៏ᛶ⑊③ཬࡧᖏ≧⑁⑈ᚋ⚄⤒③ឤཷᛶ㑇ఏᏊࡢྠᐃ ᪥ᮏே㢮㑇ఏᏛ఍➨ 64 ᅇ኱఍ 2019.11.7 㛗ᓮࣈࣜࢵࢡ࣮࣍ࣝ㸪㛗ᓮ┴㛗ᓮᕷ

4.

*Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S,
Hasegawa J, Ebata Y, Nakayama K, Hayashida M, Ikeda K Genome-wide association studiyidentifies genetic polymorphisms and genes possibly associated with chronic pain and postherpetic
neuralgia The 69th Annual Meeting of the American Society of Human Genetics (ASHG2019)2019.10.17 Houston, U.S.A.

5.

*஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯 ሗ㓘⾜ືࡢศᏊᇶ┙㹼ICSS ࢆ⏝࠸ࡓሗ㓘࣓࢝ࢽࢬ࣒ࡢゎᯒ㹼
➨ 49 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ 2019.10.13 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ－ 85 －

6.

*Du X, Ikeda K, Sundram S, Hill RA Behavioural characterisation of the GluN2DR knock-out
mouse model in response to S-ketamine and R-ketamine 6th Congress of Asian College of
Neuropsychopharmacology (AsCNP2019) 2019.10.13 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

7.

*Matsumoto T, Kotajima-Murakami H, Takano A, Ogai Y, Funada D, Tanibuchi Y, Tachimori H,
Maruo K, Ikeda K Study of ifenprodil effects on patients with methamphetamine dependence:
study protocol for an exploratory randomized double-blind placebo-controlled trial 6th Congress ofAsian College of Neuropsychopharmacology (AsCNP2019) 2019.10.13 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ
┴⚟ᒸᕷ

8.

*Ohka S, Nishizawa D, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Ikeda K
rs6738544 SNP of STAT4 and rs2298170 SNP of STAT6 are associated with nicotine dependence
6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019) 2019.10.13 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

9.

*Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa
J, Ebata Y, Nakayama K, Hayashida M, Ikeda K Genome-wide association studies on chronic pain andeffects of drugs for the treatment of pain 6th Congress of Asian College of Neuropsychopharmacology(AsCNP2019) 2019.10.13 ⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ㸤࣮࣍ࣝ㸪⚟ᒸ┴⚟ᒸᕷ

10. *Moriya Y, Hall SF, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K Behavioral
sensitization and relapse in mu-, delta- and kappa- opioid receptor knockout mice 6th Congressof Asian College of Neuropsychopharmacology (AsCNP2019) 2019.10.13 ⚟ᒸࢧࣥࣃࣞࢫ࣍
ࢸࣝ㸤࣮࣍ࣝ㸪⚟ᒸ┴⚟ᒸᕷ
11. *Aoki Y, Nishizawa D, Yoshida K, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S,
Hiranuma A, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K,
Ikeda K  Association between the rs11726196 single-nucleotide polymorphism within thetransient receptor subfamily C member 3 (TRPC3) gene and chronic pain 6th Congress of Asian
College of Neuropsychopharmacology (AsCNP2019) 2019.10.13 ⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ㸤࣮࣍ࣝ㸪⚟ᒸ┴⚟ᒸᕷ
12. *Kosaki Y, Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A,
Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y, Ichinohe T, Hayashida M, Fukuda K,
Ikeda K Associations between genetic polymorphisms on chromosome 14q32 and effects of
opioid analgesics and chronic pain 6th Congress of Asian College of Neuropsychopharmacology(AsCNP2019) 2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
13. *Inoue R, Nishizawa D, Hasegawa J, Nakayama K, Fukuda K, Sumikura H, Hayashida M, Ikeda
K Association of a candidate locus for human opioid sensitivity identified in a genome-wide
association study in patients undergoing laparoscopic-assisted colectomy with postoperative opioid
requirements in patients undergoing painful cosmetic surgery 6th Congress of Asian College of
Neuropsychopharmacology (AsCNP2019) 2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
14. *Soeda M, Ohka S, Nishizawa D, Suno M, Fukuda K, Ichinohe T, Ikeda K Association between
a Protease-activated receptor 2 gene polymorphism and cold water immersion-induced pain
sensitivity  6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)2019.10.12 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
15. *Ochiai Y, Fujita M, Hagino Y, Kobayashi K, Okiyama R, Ikeda K Analysis of the effects of serotonin
related drugs on hyperlocomotion in dopamine-deficient mice 6th Congress of Asian College of－ 86 －

Neuropsychopharmacology (AsCNP2019) 2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
16. *Kasai S, Bogdanovic N, Alkass K, Druid H Transcriptional singnatures of opioid misuse withhuman postmortem medulla  6th Congress of Asian College of Neuropsychopharmacology(AsCNP2019) 2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
17. *Kotajima H, Narumi S, Sakai K, Hashikawa T, Yuzaki M, Yanagihara D The role of the cerebellumin fear-conditioned bradycardia 6th Congress of Asian College of Neuropsychopharmacology(AsCNP2019) 2019.10.11 ⚟ᒸࢧࣥࣃࣞࢫ࣍ࢸࣝ㸤࣮࣍ࣝ㸪⚟ᒸ┴⚟ᒸᕷ
18. *Kotajima H, Kobayashi T, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda
K mTOR signaling pathway plays a key role in non-syndromic autism spectrum disorder 6th
Congress of Asian College of Neuropsychopharmacology (AsCNP2019) 2019.10.11 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ
19. *Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y,
Uchino S, Ikeda K Effects of rapamycin treatment on impaired social interaction and gene
expression in mice treated prenatally with valproic acid The 10th IBRO World Congress of
Neuroscience 2019.9.25 EXCO㸪Korea
20. *Ochiai Y, Fujita M, Hagino Y, Kobayashi K, Okiyama R, Ikeda K (2019) Effects of serotonergic
drugs on dopamine-deficient mice The 10th IBRO World Congress of Neuroscience 2019.9.22
EXCO㸪Korea
21. *ྂ⏣ᓥᾈᏊࠊᑠᯘᩄஅࠊ᯽஭ὒᩥࠊబ⸨ᩔᚿࠊⴗ㔝ὒᏊࠊ⏣୰⨾Ṍࠊす⸨Ὀᫀࠊ㧗ᯇᖾ㞝ࠊෆ㔝ⱱኵࠊụ⏣࿴㝯 ࣛࣃ࣐࢖ࢩࣥᢞ୚࡟ࡼࡿࣂࣝࣉࣟ㓟᭚㟢࣐࢘ࢫࡢ♫఍ᛶ⾜ື㞀ᐖ࡜㑇ఏᏊⓎ⌧࡬ࡢᙳ㡪 ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨ 62 ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ྜྠ኱
఍ 2019.7.27 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
22. *す⃝኱㍜ࠊụ⏣࿴㝯ࠊ㛗㇂ᕝ‽Ꮚࠊ᳥ᮧ᫓ᙪ ࢽࢥࢳࣥ➼≀㉁౫Ꮡ⬤ᙅᛶ࣭㔜⑕ᗘಶேᕪ࡟࠾ࡅࡿࢤࣀ࣒࣡࢖ࢻࢥࣆ࣮ᩘከᆺ࣭ኚ␗ゎᯒ බ┈㈈ᅋἲேႚ↮⛉Ꮫ◊✲㈈ᅋ➨ 34
ᅇᖹᡂ 30 ᖺᗘຓᡂ◊✲Ⓨ⾲఍ 2019.7.23 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊
23. *ྂ⏣ᓥᾈᏊࠊす⃝኱㍜ࠊụ⏣࿴㝯 ࢖ࣇ࢙ࣥࣉࣟࢪࣝࡢႚ↮ḧồᥦゝຠᯝ࡟㛵ࡍࡿ⮫ᗋ◊✲බ┈㈈ᅋἲேႚ↮⛉Ꮫ◊✲㈈ᅋ ➨ 34 ᅇᖹᡂ 30 ᖺᗘຓᡂ◊✲Ⓨ⾲఍ 2019.7.23 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊
24. *Moriya Y, Hall FS, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K Opioid system
is involved in modulating the development of behavioral sensitization to METH  The
International Narcotics Research Conference (INRC) 2019 2019.7.10 New York at the Grand
Hyatt New York㸪U.S.A.
25. *Moriya Y, Hall FS, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K Role of opioid
receptors in behavioral sensitization to methamphetamine  The International Behavioral
Neuroscience Society (IBNS) 2019.6.26 Cairns Convention Centre,Cairns, Queensland, Australia
26. ῧ⏣ⴌࠊ኱ᒸ㟼⾰ࠊす⃝኱㍜ࠊ㡲㔝Ꮫࠊ⚟⏣ㅬ୍ࠊ୍ᡞ㐩ஓࠊụ⏣࿴㝯 ࣉࣟࢸ࢔࣮ࢮά
ᛶ໬ཷᐜయ PAR2 (protease-activated receptor 2) ࡢ㑇ఏᏊከᆺ࡜෭Ỉ่⃭ㄏⓎᛶ⑊③ឤཷᛶࡢ㛵㐃 ➨ 13 ᅇ᪥ᮏ⦆࿴་⒪⸆Ꮫ఍ᖺ఍ 2019.6.2 ᖥᙇ࣓ࢵࢭ㸪༓ⴥ┴༓ⴥᕷ－ 87 －

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 6 ௳㸧1.

ụ⏣࿴㝯 ౫Ꮡ⑕ࢆࡵࡄࡿ᭱㏆ࡢືࡁ [ㅮ₇]2019 ᖺᗘ➨ 7 ᅇ㒔་Ꮫ◊㒔Ẹㅮᗙࠕ౫Ꮡ⑕
࡟ṇࡋࡃྥࡁྜ࠺ 㸫ண㜵ࠊ἞⒪ࠊᅇ᚟㸫ࠖ 2020.1.18 ୍ᶫㅮᇽ㸪ᮾி㒔༓௦⏣༊2.

ụ⏣࿴㝯 ࢜ࣆ࢜࢖ࢻࢩࢫࢸ࣒࡟ࡼࡿ⑊③ไᚚ [ㅮ⩏]⩌㤿኱Ꮫ኱Ꮫ㝔ㅮ⩏ ⬻⚄⤒෌⏕་Ꮫศ㔝ࢭ࣑ࢼ࣮ 2020.1.17 ⩌㤿኱Ꮫ㸪⩌㤿┴๓ᶫᕷ3.

ụ⏣࿴㝯 ࢔ࢹ࢕ࢡࢩࣙࣥࡢ⛉Ꮫ [ㅮ⩏]⩌㤿኱Ꮫ་Ꮫ㒊 ≉ูㅮ⩏ 2020.1.17 ⩌㤿኱Ꮫ㸪⩌㤿┴๓ᶫᕷ

4.

ụ⏣࿴㝯 ౫Ꮡ⑕ࡢᇶ♏▱㆑ [ㅮ₇]ୡ⏣㇂༊❧ඵᖭᒣᑠᏛᰯ⸆≀஘⏝㜵Ṇㅮ⩦఍
2019.12.2 ඵᖭᒣᑠᏛᰯ㸪ᮾி㒔ୡ⏣㇂༊5.

ụ⏣࿴㝯 ᣑ኱ࡍࡿ࢔ࢹ࢕ࢡࢩࣙࣥၥ㢟࡬ࡢᏛ⾡ⓗᑐᛂ [ㅮ₇]ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ ≉ูㅮ₇఍ 2019.11.15 ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ㸪⚄ዉᕝ┴ᕝᓮᕷ6.

ụ⏣࿴㝯 ౫Ꮡ⑕࡟࠾ࡅࡿ࢜ࣞ࢟ࢩࣥࢩࢫࢸ࣒ࡢ㛵୚ [ㅮ₇]ࡘࡃࡤ࢔࢝ࢹ࣑࣮࣭࢜ࣈ࣭ࢧ
࢖࢝࢖࢔ࢺ࣮ࣜ(TAP)2019 2nd Ꮫ⾡ㅮ₇఍ 2019.8.30 ⛅ⴥཎ UDX ࢝ࣥࣇ࢓ࣞࣥࢫ ༡࢘࢕ࣥࢢ㸪ᮾி㒔༓௦⏣༊IV. ≉グ஦㡯࠙≉チࠚ
1.

Ikeda K, Nishizawa D, Fukuda K  Method for evaluating drug sensitivity and disease
vulnerability by analyzing cyclic AMP responsive element binding protein gene. [ᡂ❧] European
Patent Office, 2787076 2019.8.28

࣐࠙ࢫࢥ࣑ࠚ
1.

ụ⏣࿴㝯  㔜ᗘࡢ⸆≀౫Ꮡ࡛ⱞࡋࢇ࡛࠸ࡿேࡢᚰ᝟࡟ࡘ࠸࡚ [ྲྀᮦ]ࣇࢪࢸࣞࣅ LiveNews it! 2019.11.202.

ụ⏣࿴㝯 ⢭⚄࣭⚄⤒⑌ᝈࡢ἞⒪⸆ࡢࠕ༴ᶵࠖ࡜᪥ᮏࡢᙺ๭ [ྲྀᮦ]ᮅ᪥᪂⪺♫ゝㄽࢧ࢖ࢺㄽᗙ 2019.11.15

3.

ụ⏣࿴㝯 ➨ 6 ᅇ࢔ࢪ࢔⚄⤒⢭⚄⸆⌮Ꮫ఍኱఍࠾ࡼࡧࣝࣥࢻ࣋ࢵࢡ㈹ࡢタ⨨࡟ࡘ࠸࡚
[ྲྀᮦ]ẖ᪥࣓ࢹ࢕࢝ࣝࢪ࣮ࣕࢼࣝ 12࣭1 ᭶ྕ 2019.11.13

4.

ụ⏣࿴㝯 ぬࡏ࠸๣౫Ꮡࡢ἞⒪ἲ࡟ࡘ࠸࡚ [ྲྀᮦ]ࢸࣞࣅᮅ᪥ AbemaPrime 2019.11.7

5.

ụ⏣࿴㝯 ࢔ࣝࢥ࣮ࣝࡀ⬻࡟୚࠼ࡿᙳ㡪࡟㛵ࡍࡿᅗゎ࡟ࡘ࠸࡚ [ྲྀᮦ]NHK NHK ࢫ࣌ࢩࣕࣝࠕ㣗ࡢ㉳※ࠖ 2019.10.21

࠙ཷ㈹ࠚ
1.

᳃ᒇ⏤⣖ 2019 ᖺ AsCNP Outstanding Research Award for AsCNP2019㸦2019 ᖺ 10 ᭶㸧

2.

す⃝኱㍜ 2019 ᖺ AsCNP Outstanding Research Award for AsCNP2019㸦2019 ᖺ 10 ᭶㸧3.

㟷ᮌㅬ඾ 2019 ᖺ AsCNP Outstanding Research Award for AsCNP2019㸦2019 ᖺ 10 ᭶㸧

4.

ᑠᓮⰾᙪ 2019 ᖺ AsCNP Excellent Research Award for AsCNP2019㸦2019 ᖺ 10 ᭶㸧

5.

஭ୖ⌮ᜨ 2019 ᖺ AsCNP Excellent Presentation Award for AsCNP2019㸦2019 ᖺ 10 ᭶㸧࠙⾜ᨻጤဨࠊᩍဨࠚ
1.

ụ⏣࿴㝯㸦2018 ᖺ 12 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ពᛮỴᐃ஦ᴗ ホ౯ጤဨ఍ጤဨ

2.

ụ⏣࿴㝯㸦2019 ᖺ 11 ᭶-⌧ᅾ㸧ᮾி㒔࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇᥎㐍ጤဨ఍ጤဨ
－ 88 －

3.

ụ⏣࿴㝯㸦2017 ᖺ 12 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ 㞴἞ᛶ⑌ᝈᐇ⏝໬◊✲஦ᴗ ㄢ㢟ホ౯ጤဨ఍ጤဨ

4.

ụ⏣࿴㝯㸦2017 ᖺ 4 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ⬻⛉Ꮫ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ⬻⛉Ꮫ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ㸦⼥ྜ⬻㸧ㄢ㢟ホ౯ጤဨ఍ጤဨ

5.

ụ⏣࿴㝯㸦2017 ᖺ 1 ᭶-⌧ᅾ㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ⸆஦࣭㣗ရ⾨⏕ᑂ㆟఍⮫᫬ጤဨ6.

ụ⏣࿴㝯㸦2017 ᖺ 1 ᭶-2020 ᖺ 3 ᭶㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ┘どᣦᑟ࣭㯞⸆ᑐ⟇ㄢ ౫Ꮡᛶ⸆≀᳨ウ఍ᵓᡂဨ7.

ụ⏣࿴㝯㸦2016 ᖺ 4 ᭶-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ⼥ྜ⬻஦ᴗࣉࣟࢢ࣒ࣛ࢜ࣇ࢕ࢧ࣮

8.

ụ⏣࿴㝯㸦2019 ᖺ 10 ᭶-⌧ᅾ㸧៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊࣭ᐈဨᩍᤵ

9.

ụ⏣࿴㝯㸦2019 ᖺ 10 ᭶-2020 ᖺ 3 ᭶㸧⩌㤿኱Ꮫ་Ꮫ㒊㸸㠀ᖖ໅ㅮᖌ10. ụ⏣࿴㝯㸦2019 ᖺ 10 ᭶-2020 ᖺ 3 ᭶㸧⩌㤿኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉࣭㠀ᖖ໅ㅮᖌ
11. ụ⏣࿴㝯㸦2014 ᖺ 4 ᭶-⌧ᅾ㸧᪂₲኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉࣭ᐈဨᩍᤵ
12. ኱ᒸ㟼⾰㸦2016 ᖺ-⌧ᅾ㸧ᩥ㒊⛉Ꮫ┬ 㑇ఏᏊ⤌᥮࠼ᢏ⾡➼ᑓ㛛ጤဨ࠙Ꮫ఍ᙺဨࠚ
1.

ụ⏣࿴㝯㸦2018-⌧ᅾ㸧᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ ᑗ᮶ᵓ᝿ጤဨ

2.

ụ⏣࿴㝯㸦2012-⌧ᅾ㸧᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ ホ㆟ဨ

3.

ụ⏣࿴㝯㸦2019-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⛉Ꮫ⪅ጤဨ఍◊✲ィ⏬࣭◊✲㈨㔠᳨ウศ⛉఍ ⮫ᗋ་Ꮫศ㔝ࡢ኱ᆺ◊✲ィ⏬ホ౯ᑠศ⛉఍ ᖿ஦4.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⚄⤒⛉Ꮫศ⛉఍ጤဨ5.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ࢔ࢹ࢕ࢡࢩࣙࣥศ⛉఍ጤဨ㛗6.

ụ⏣࿴㝯㸦2015-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⬻࡜ࡇࡇࢁศ⛉఍ᖿ஦7.

ụ⏣࿴㝯㸦2014-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ 㐃ᦠ఍ဨ8.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ Ꮫ⾡ホ㆟ဨ

9.

ụ⏣࿴㝯㸦2014-⌧ᅾ㸧᪥ᮏ⚄⤒⛉ᏛᏛ఍ ఍ィ┘஦10. ụ⏣࿴㝯㸦2018-2020㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ 50 ࿘ᖺグᛕ஦ᴗ࣮࣡࢟ࣥࢢࢢ࣮ࣝࣉጤဨ㛗
11. ụ⏣࿴㝯㸦2013-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⌮஦
12. ụ⏣࿴㝯㸦2004-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
13. ụ⏣࿴㝯㸦2012-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ᗈሗጤဨ㛗
14. ụ⏣࿴㝯㸦2008-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ⌮஦
15. ụ⏣࿴㝯㸦2005-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ホ㆟ဨ
16. ụ⏣࿴㝯㸦2006-⌧ᅾ㸧㙠③⸆࣭࢜ࣆ࢜࢖ࢻ࣌ࣉࢳࢻ◊✲఍(JNRC) ୡヰே
17. Ikeda K㸦2017-present㸧International Brain Research Organization (IBRO), CJK ጤဨ
18. Ikeda K㸦2018-present㸧International College of Neuropsychopharmacology (CINP), Treasurer
19. Ikeda K㸦2018-present㸧International College of Neuropsychopharmacology (CINP), Credentials
and Membership Committee Chair
20. Ikeda K㸦2018-present㸧International College of Neuropsychopharmacology (CINP), Finance andBudget Committee Chair
21. Ikeda K㸦2014-present㸧International College of Neuropsychopharmacology (CINP), Constitution
and By-law Committee Member
22. Ikeda K㸦2019-2020㸧Asian College of Neuropsychopharmacology (AsCNP), President－ 89 －

23. ➟஭ៅஓ㸦2016-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ホ㆟ဨ
24. ➟஭ៅஓ㸦2012-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
25. ➟஭ៅஓ㸦2016-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⦅㞟ጤဨ఍ጤဨ
26. ஭ᡭ⪽୍㑻㸦2016-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
27. ஭ᡭ⪽୍㑻㸦2013-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ ḟୡ௦ࡢ఍ ୡヰே
28. ஭ᡭ⪽୍㑻㸦2017-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ Ꮫ⾡ホ㆟ဨ
29. す⃝኱㍜㸦2012-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ࠙Ꮫ⾡㞧ㄅ⦅㞟ࠚ
1.

Ikeda K㸦2018-present㸧Associate Editor㸪Neuropsychopharmacology Reports

2.

Ikeda K㸦2017-present㸧Field Editor㸪Alcoholism: Clinical & Experimental Research3.

Ikeda K㸦2012-present㸧Editorial Advisory Board Member㸪Addiction Genetics

4.

Ikeda K㸦2012-present㸧Associate Editor Board Member㸪Journal of Drug and Alcohol Research5.

Ikeda K㸦2009-present㸧Academic Editor㸪PLoS ONE

6.

Ikeda K㸦2008-present㸧Editorial Advisory Board Member㸪The Open Pain Journal

7.

Ikeda K㸦2008-present㸧Editorial Advisory Board Member㸪The Open Neuropsychopharmacology
Journal8.

Kasai S㸦2017-present㸧Associated editor㸪Neuropsychopharmacology Reports

9.

Kasai S㸦2016-present㸧Editorial Board Member㸪Pain Research & Management

10. Kasai S㸦2014-present㸧Editorial Board Member㸪Journal of Schizophrenia Research
11. Kasai S㸦2014-present㸧Editorial Board Member㸪Journal of Addiction Medicine & Therapy
12. Nishizawa D㸦2014-present㸧Editorial Board Member㸪Journal of Addiction Medicine & Therapy࠙ࡑࡢ௚ࡢάືࠚ
1.

ụ⏣࿴㝯 (2020) ⏕⌮ᶵ⬟ゎᯒᡂᯝ࣮࣡ࢡࢩࣙࢵࣉ 2 [ᗙ㛗] ௧࿴ඖ(2019)ᖺᗘ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ ᡂᯝⓎ⾲఍ 2020.2.4 ⍇⍈†࣍ࢸࣝ㸪⁠㈡┴኱ὠᕷ2.

ụ⏣࿴㝯 (2020) ⏕⌮ᶵ⬟ゎᯒᡂᯝ࣮࣡ࢡࢩࣙࢵࣉ 1 [ᗙ㛗] ௧࿴ඖ(2019)ᖺᗘ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ ᡂᯝⓎ⾲఍ 2020.2.4 ⍇⍈†࣍ࢸࣝ㸪⁠㈡┴኱ὠᕷ3.

ụ⏣࿴㝯 (2020) ࠕ౫Ꮡ⑕࡟ṇࡋࡃྥࡁྜ࠺ 㸫ண㜵ࠊ἞⒪ࠊᅇ᚟㸫ࠖ [ᗙ㛗] 2019 ᖺᗘ➨ 7 ᅇ㒔་Ꮫ◊㒔Ẹㅮᗙ 2020.1.18 ୍ᶫㅮᇽ㸪ᮾி㒔༓௦⏣༊

4.

ụ⏣࿴㝯 (2019) ᩍ⫱ㅮ₇ 9 [ᗙ㛗] 2019 ᖺᗘ࢔ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍ 2019.10.6 ᖠࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸪໭ᾏ㐨ᮐᖠᕷ－ 90 －

ࣉࣟࢪ࢙ࢡࢺྡ

࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧ᰝㄞ࠶ࡾ1.

Kim D H, Beckett J D, Nagpal V, Seman-Senderos M A, Gould R A, Creamer T J, MacFarlane E
G, Chen Y, Bedja D, Butcher J T, Mitzner W, Rouf R, Hata S, Warren D S, *Dietz H C. (2019)
Calpain 9 as a therapeutic target in TGFbeta-induced mesenchymal transition and fibrosis. Sci.
Transl. Med. 11, eaau2814

2.

Hata S, Doi N, Shinkai-Ouchi F, Ono Y. (2020) A muscle-specific calpain, CAPN3, forms ahomotrimer. Biochim. Biophys. Acta Proteins Proteom. 1868, 140411

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

Yasuko Ono Unexpected protein products from calpain-10 (CAPN10) cDNA The Biology of
Calpains in Health and Disease Conference 2019.7.17 Pacific Grove,California,U.S.A.

2.

*Shoji HataࠊYasumasa NishitoࠊNaoko DoiࠊFujiko KitamuraࠊHiroyuki SorimachiࠊYasuko Ono
Aberrant activation of a skin-specific calpain, CAPN12 is involved in the development ofpsoriasis. The Biology of Calpains in Health and Disease Conference 2019.7.17 PacificGrove,California,U.S.A.

ࡑࡢ௚ 㸦ィ 5 ௳㸧⮬⏤ᥖ㍕
1.

*኱ෆྐᏊࠊ㐍⸨┿⏤⨾ࠊఀ⸨⩏ᇛࠊᅵ஭ዉ✑Ꮚࠊ⛙຾ᚿࠊᑠ㔝ᘺᏊ ⫥ᖏᆺ➽ࢪࢫࢺࣟ
ࣇ࢕࣮2A ࣔࢹ࣐ࣝ࢘ࢫࡢศᏊ⑓ែゎᯒ ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019.9.18 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ

2.

*኱ෆྐᏊࠊఀ⸨⩏ᇛࠊ୕ୖᜤᖹࠊᅵ஭ዉ✑Ꮚࠊ⛙຾ᚿࠊᑠ㔝ᘺᏊ ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ
࢕࣮2A ᆺࣔࢹ࣐ࣝ࢘ࢫࡢ⤒᫬ⓗኚ໬ ᪥ᮏ➽Ꮫ఍➨ 5 ᅇᏛ⾡㞟఍ 2019.8.2 ఀ⸨ᅜ㝿Ꮫ⾡◊✲ࢭࣥࢱ࣮ఀ⸨ㅰᜠ࣮࣍ࣝ㸪ᮾி㒔ᩥி༊

3.

*Aya Noguchi ࠊ Shoji Hata ࠊ Naoko Doi ࠊ Yasushi Saeki ࠊ Keiji Tanaka ࠊ Yasuko Ono
Characterrization of polybiquitin binding capain, CAPN15. The Biology of Calpains in Healthand Disease Conference 2019.7.17 Pacific Grove,California,U.S.A.

4.

*Fumiko Shinkai-OuchiࠊMayumi ShindoࠊShoji HataࠊNaoko DoiࠊHiroyuki SorimachiࠊYasuko
Ono Differential processing of troponin T by calpain-1 and calpain-2

－ 91 －The Biology of Calpains

in Health and Disease Conference 2019.7.17 Pacific Grove,California,U.S.A.
5.

Ojima K, Hata S, Shinkai-Ouchi F, Oe M, Muroya S, Sorimachi H, Ono Y: FRET-based probes
capture proteolytically activated muscle-specific calpain-3 (CAPN3) in myotubes. FASEB
Summer Research Conferences The Biology of Calpains in Health and Disease Conference
2019.7.15 Pacific Grove,California,U.S.A.

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯࡞ࡋ－ 92 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Koyano, F., Yamano, K., Kosako, H., Kimura, Y., Kimura, M., Fujiki, Y., Tanaka, K., and*Matsuda, N. Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria toperoxisomes. EMBO Rep., 20: e47728 (2019).

2.

Koyano, F., Yamano, K., Kosako, H., Tanaka, K., and *Matsuda, N. Parkin recruitment to impaired
mitochondria for nonselective ubiquitylation is facilitated by MITOL. J. Biol. Chem., 294:
10300-10314 (2019).

3.

Yamaguchi, A., Ishikawa, H., Furuoka, M., Yokozeki, M., Matsuda, N., Tanimura S., and *Takeda K.
Cleaved PGAM5 is released from mitochondria depending on proteasome-dependent rupture of theouter mitochondrial membrane during mitophagy. J. Biochemistry, 165: 19-25 (2019).

4.

Higurashi, M., Maruyama, T., Nogami, Y., Ishikawa, F., Yoshida, Y., Mori, K., Fujita, K.,
Shibanuma, M. High expression of FOXM1 critical for sustaining cell proliferation in
mitochondrial DNA-less liver cancer cells. Exp. Cell Res., 389: 11889 (2020).

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 7 ௳㸧
1.

*Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K. Detection of ubiquitination activity andidentification of ubiquitinated substrates using TR-TUBE. Methods Enzymol., 618: 135-147(2019). ᰝㄞ࠶ࡾ2.

*Yoshida, Y., Mizushima, T., and Tanaka, K. Sugar-recognizing ubiquitin ligases: Action
mechanisms and physiology. Front. Physiol., 10: 104 (2019). ᰝㄞ࠶ࡾ3.

*ᯇ⏣᠇அ PINK1/Parkin ౫Ꮡᛶ࣐࢖ࢺࣇ࢓ࢪ࣮࡟࠾ࡅࡿ Parkin άᛶ໬ࡢศᏊᶵᵓࠊ⏕⏕໬Ꮫ㸪➨ 91 ᕳ ➨ 5 ྕ, pp 626-633 (2019).

4.

*ᯇ⏣᠇அ ⣽⬊ࡢᜏᖖᛶ⥔ᣢࢆᢸ࠺ືⓗ࡞ࣘࣅ࢟ࢳࣥಟ㣭ࠊᐇᐇ㦂་Ꮫࠊ⨺ᅵ♫ࠊVol. 37,
No. 7 㸦ቑหྕࠕ⮚ჾ㐃⎔࡟ࡼࡿ⏕యᜏᖖᛶࡢ⥔ᣢࡢ◚⥢࡜⑌ᝈࠖ㸧, pp 1038-1050 (2019).

5.

*ᒣ㔝᫭ྐ ᦆയ࣑ࢺࢥࣥࢻࣜ࢔ࡢ㑅ᢥⓗศゎࠊ⏕໬Ꮫ㸪➨ 91 ᕳ ➨ 3 ྕ, pp 369-379 (2019).

6.

*ᒣ㔝᫭ྐ ୙Ⰻ࣑ࢺࢥࣥࢻࣜ࢔ศゎࢆྖࡿ Parkin ࡜ PINK1ࠊࣇ࢓࣐ࣝࢩ࢔㸦බ┈㈈ᅋἲ
ே ᪥ᮏ⸆Ꮫ఍㸧Vol.56, No.1, pp 16-20 (2020)7.

*ᒣ㔝᫭ྐ ࣐࢖ࢺࣇ࢓ࢪ࣮㸸ᦆയ࣑ࢺࢥࣥࢻࣜ࢔ࡢ㑅ᢥⓗศゎࠊDOJIN NEWS㸦ᰴᘧ఍♫ ྠோ໬Ꮫ◊✲ᡤ㸧No.171, pp 1-4 (2019)－ 93 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇㸦ィ 11 ௳㸧
1.

Yoshida.Y. Functional genetic interaction between Ngly1 and a lectin-type ubiquitin ligase in mice.
RIKEN-Interanational Symposium ‘Glyco-lipidologue Symposium 2020.1.20㹼1.21, ⌮◊࣭㕥ᮌᱵኴ㑻࣮࣍ࣝ㸪ᇸ⋢┴2.

ᒣ 㔝 ᫭ ྐ  ୙ Ⰻ ࣑ ࢺ ࢥ ࣥ ࢻ ࣜ ࢔ 㑅 ᢥ ⓗ ศ ゎ ࡢ ศ Ꮚ ᶵ ᵓ  Mitochondria Symposium
2019.11.25 ៞᠕⩏ሿ኱Ꮫಙ⃰⏫࢟ࣕࣥࣃࢫ⥲ྜ་⛉Ꮫ◊✲Ჷ 1F ࣛ࢘ࣥࢪ㸪ᮾி㒔᪂ᐟ༊

3.

Matsuda. N.: New role for PINK1/Parkin-mediated ubiquitylation. Singapore Mitochondrial
Mini-Symposium 2019, Invited as Plenary Speaker, 2019.11.12, National University of Singapore(NUS), Singapore

4.

ᒣ㔝᫭ྐ ࢫࢺࣞࢫ࡟ᛂ⟅ࡋࡓᦆയ࣑ࢺࢥࣥࢻࣜ࢔ࡢ㑅ᢥⓗศゎ ➨ 14 ᅇ᪥ᮏ⮫ᗋࢫࢺࣞࢫᛂ⟅Ꮫ఍ 2019.11.2㹼11.3 ኱㜰ᕷ❧኱Ꮫ㜿ಸ㔝࢟ࣕࣥࣃࢫ㸪኱㜰ᗓ኱㜰ᕷ

5.

ᯇ⏣᠇அ PINK1, Parkin, DJ-1 ࡣ࣑ࢺࢥࣥࢻࣜ࢔ရ㉁⟶⌮ࡸ࢔ࣝࢹࣄࢻゎẘࢆ௓ࡋ࡚ࣃ࣮
࢟ࣥࢯࣥ⑓ࢆ㜵Ṇࡍࡿ ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019.9.18㹼9.20 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ

6.

ᑠ㇂㔝ྐ㤶ࠊᒣ㔝᫭ྐࠊᑠ㏕ⱥᑛࠊ⏣୰ၨ஧ࠊᯇ⏣᠇அ Parkin ࡣᦆയ࣑ࢺࢥࣥࢻࣜ࢔ࡢ
㑅ᢥⓗ㝖ཤࢆ௰௓ࡋ MITOL/March5 ࢆ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡟⛣⾜ࡉࡏࡿ ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019.9.19 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ

7.

ᯇ⏣᠇அ ⑌ᝈࢆ㜵Ṇࡍࡿ࣑ࢺࢥࣥࢻࣜ࢔ࣜࣔࢹࣜࣥࢢࡢศᏊ࣓࢝ࢽࢬ࣒ࠥࣘࣅ࢟ࢳࣥࢆ௓
ࡋࡓ㑅ᢥ࡜ศゎࠥ ➨ 27 ᅇᮌཎグᛕ㈈ᅋᏛ⾡㈹
 2019.9.17 ᝟ᩥ࣮࣍ࣝ㸪⚄ዉᕝ┴ᶓ὾ᕷ8.

ྜྷ⏣㞷Ꮚ Ngly1 ࡜⢾㙐ㄆ㆑ࣘࣅ࢟ࢳ࣮ࣥࣜ࢞ࢮ SCFFbx06 ࡢ࣐࢘ࢫ࡟࠾ࡅࡿ㑇ఏⓗ┦஫స⏝ ➨ 38 ᅇ᪥ᮏ⢾㉁Ꮫ఍ᖺ఍ 2019.8.21 ྡྂᒇ኱Ꮫ㇏⏣ㅮᇽ࣭ࢩ࣏ࣥࢪ࢜ࣥ㸪ឡ▱
┴ྡྂᒇᕷ

9.

ᯇ⏣᠇அ ࣑ࢺࢥࣥࢻࣜ࢔-ࣜࢯࢯ࣮࣒㐃ᦠࡢ◚⥢࡜ࣃ࣮࢟ࣥࢯࣥ⑓ Neuro 2019 (➨ 42ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ ➨ 62 ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ ྜྠ኱఍) 2019.7.27 ᮒ㮛࣓ࢵࢭࠊ࣍
ࢸࣝ᪥⯟, ᪂₲┴᪂₲ᕷ

10. Matsuda. N.: PINK1, Parkin and the ubiquitin system in TP5 – The Proteinopathy of Parkinson’s
disease and its role in pathogenesis. 5th WPC (5th World Parkinson Congress), 2019.6.4 㹼6.7,
ி㒔ᅜ㝿఍㆟ሙ, ி㒔ᗓி㒔ᕷ
11. Yoshida. Y. Loss of a lectin-type E3 ligase gene rescues the lethality and defects of NGLY-KO
mice. CIFAR Genetic Networks Program Meeting 2019.4.1 Santa Cruz, USAࡑࡢ௚ Ꮫ఍Ⓨ⾲ࡸ࣮࣡ࢡࢩࣙࢵࣉⓎ⾲➼㸦ィ 12 ௳㸧1.

ᯇ⏣᠇அ ⭷㟁఩పୗ࡛㥑ືࡉࢀࡿ࣐࢖ࢺࣇ࢓ࢪ࣮ࡢศᏊ࣓࢝ࢽࢬ࣒ ᇶ⏕◊ࢭ࣑ࢼ࣮2020.2.17 ᇶ♏⏕≀Ꮫ◊✲ᡤ㸪ឡ▱┴ᒸᓮᕷ2.

ᒣ㔝᫭ྐ SNIPER ࡟ࡼࡿ࣐࢖ࢺࣇ࢓ࢪ࣮ㄏᑟ࡜࢔ࢲࣉࢱ࣮ศᏊࡢ᪂ᐃ⩏ ᪂Ꮫ⾡㡿ᇦࠕࢣࣔࣘࣅ࢟ࢳࣥࠖ➨ 3 ᅇ⌜఍㆟ 2019.12.17㹼12.19 ࣍ࢸࣝ㸤ࣜࢰ࣮ࢶ༡ᡣ⥲㸪༓ⴥ┴
༡ᡣ⥲ᕷ

3.

ᒣ㔝᫭ྐ Molecular Mechanism of Ubiquitin-Dependent Mitophagy 2019 ASCB/EMBO
Meeting 2019.12.7㹼12.11 Washington D.C.㸪U.S.A.

－ 94 －

4.

ᒣ㔝᫭ྐ ࣃ࣮࢟ࣥࢯࣥ⑓ࡢ㘽ࢆᥱࡿᦆയ࣑ࢺࢥࣥࢻࣜ࢔㑅ᢥⓗศゎ NIH ➨ 165 ᅇ㔠᭙఍ࢭ࣑ࢼ࣮ 2019.12.6 NIH37Bldg, Maryland㸪U.S.A.

5.

*ᯇ⏣᠇அࠊᑠ㇂㔝ྐ㤶ࠊᒣ㔝᫭ྐࠊᑠ㏕ⱥᑛࠊ⏣୰ၨ஧ ࣘࣅ࢟ࢳࣥ໬ࡀᘬࡁ㉳ࡇࡍ࣑ࢺࢥࣥࢻࣜ࢔㸫࣌ࣝ࢜࢟ࢩࢯ࣮࣒⛣⾜ ➨ 12 ᅇ࣮࢜ࢺࣇ࢓ࢪ࣮◊✲఍㸭➨㸯ᅇ᪂Ꮫ⾡㡿ᇦࠕ࣐ࣝࢳ࣮ࣔࢻ࣮࢜ࢺࣇ࢓ࢪ࣮ࠖ⌜఍㆟ 2019.10.25㹼10.26 ࡘࡲᜊࣜࢰ࣮ࢺᙬࡢ㒓㸪㟼ᒸ┴᥃ᕝᕷ

6.

ᑠᓥ࿴⳹ ᪂つ࣮࢜ࢺࣇ࢓ࢪ࣮㛵㐃ᅉᏊࡢྠᐃ࡜ࡑࡢᶵ⬟ゎᯒ ➨ 12 ᅇ࣮࢜ࢺࣇ࢓ࢪ࣮
◊✲఍㸭➨㸯ᅇ᪂Ꮫ⾡㡿ᇦࠕ࣐ࣝࢳ࣮ࣔࢻ࣮࢜ࢺࣇ࢓ࢪ࣮ࠖ⌜఍㆟ 2019.10.25 ࡘࡲᜊࣜࢰ࣮ࢺᙬࡢ㒓㸪㟼ᒸ┴᥃ᕝᕷ

7.

ᑠᓥ࿴⳹ Functional analysis of new autophagy factors. ࢜ࣝ࢞ࢿࣛ◊✲఍ 2019.9.27㹼
9.29 㔠ἑ኱Ꮫᐆ⏫࣭㭯㛫࢟ࣕࣥࣃࢫ㸪▼ᕝ┴㔠ἑᕷ8.

ᑠ㇂㔝ྐ㤶 MITOL moves to peroxisomes on mitophagy ࢜ࣝ࢞ࢿࣛ◊✲఍ 2019.9.27㹼
9.29 㔠ἑ኱Ꮫᐆ⏫࣭㭯㛫࢟ࣕࣥࣃࢫ㸪▼ᕝ┴㔠ἑᕷ

9.

ᒣ㔝᫭ྐ New Definition of Autophagy Adaptors ࢜ࣝ࢞ࢿࣛ◊✲఍ 2019.9.27㹼9.29 㔠ἑ኱Ꮫᐆ⏫࣭㭯㛫࢟ࣕࣥࣃࢫ㸪▼ᕝ┴㔠ἑᕷ

10. ᑠᓥ࿴⳹ Identify me if you can 㸫᪂つ࣮࢜ࢺࣇ࢓ࢪ࣮ᅉᏊࡢᶵ⬟ゎᯒ㸫 ࣑ࢺࢥࣥࢻࣜ
࢔ࢧ࢖࢚ࣥࢫ࣮࣡ࢡࢩࣙࢵࣉ 2019.5.14㹼5.15 ி㒔ᗓடᒸᕷ
11. ᑠ㇂㔝ྐ㤶 Parkin ࡀึᮇᦆയ࣑ࢺࢥࣥࢻࣜ࢔࡟⛣⾜ࡍࡿ࣓࢝ࢽࢬ࣒ ࣑ࢺࢥࣥࢻࣜ࢔ࢧ
࢖࢚ࣥࢫ࣮࣡ࢡࢩࣙࢵࣉ 2019.5.14㹼5.15 ி㒔ᗓடᒸᕷ12. ᒣ㔝᫭ྐ ⱝᡭ◊✲⪅ࡀ࣑ࢺࢥࣥࢻࣜ࢔ࢧ࢖࢚ࣥࢫ࡟㈉⊩࡛ࡁࡿࡇ࡜ ࣑ࢺࢥࣥࢻࣜ࢔
ࢧ࢖࢚ࣥࢫ࣮࣡ࢡࢩࣙࢵࣉ 2019 2019.5.14㹼5.15 ி㒔࣭ⅼἙ㸪ி㒔ᗓடᒸᕷ
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 2 ௳㸧ᯇ⏣᠇அ ໭㔛኱Ꮫ ኱Ꮫ㝔ㅮ⩏ 2019.7.5
ᯇ⏣᠇அ 㤳㒔኱Ꮫᮾி ኱Ꮫ㝔ㅮ⩏ 2019.9.9
IV. ≉グ஦㡯࡞ࡋ－ 95 －

ࣉࣟࢪ࢙ࢡࢺྡ

ᖿ⣽⬊ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

M. Nakajima, T. Suzuki, *T. Hara, and *K. Kitajima. In vitro differentiation of mouse T
cell-derived hybrid cells obtained through cell fusion with embryonic stem cells. Biochem.
Biophys. Res. Commun., 513: 701-707, 2019. *Co-corresponding authors.

2.

H. Tabata, *T. Hara, and *K. Kitajima. Inhibitory action of an ERK1/2 inhibitor on primitive
endoderm cell differentiation from mouse embryonic stem cells. Biochem. Biophys. Res.
Commun., 512: 399-404, 2019. *Co-corresponding authors.

3.

M. Paulis, L. Susani, A. Castelli, T. Suzuki, T. Hara, L. Straniero, S. Duga, D. Strina, S. Mantero,
E. Caldana, L. S. Sergi, A. Villa, and P. Vezzoni. Chromosome transplantation: a possible approach
to treat human X-linked disorders. Mol. Ther. Methods Clin. Dev., 17: 369-377, 2020.

4.

K. Sato, M. Maeda, E. Kamata, S. Ishii, K. Yanagisawa, K. Kitajima, and T. Hara. Nitric oxide anda conditioned medium affect the hematopoietic development in a microfluidic mouse embryonicstem cell/OP9 co-cultivation system. Micromachines, 11: 305, 2020.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 9 ௳㸧⮬⏤ᥖ㍕
1.

㕥ᮌ㍤ᙪࠊ㜿㒊ᬛᚿࠊᐩሯ୍☻ࠊᒸ⏣ⲁࠊ㤶᭶ຍዉᏊࠊᢲᮧග㞝ࠊཎᏕᙪࠊ㤶᭶ᗣᏹ ࣄࢺ㸭࣐࢘ࢫேᕤᰁⰍయᢏ⾡ᛂ⏝㸦2㸧㸸ᕧ኱ྜᡂ㓄ิࢆᑟධࡍࡿᢏ⾡ࡢ㛤Ⓨ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.4 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

2.

୰⏣༓ᑜ ࠊඵᮌᣅဢ ࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊᮾᬛஓࠊṊᬛ࠶࡙ࡉ ࠊす⸨Ὀᫀࠊ∾ᫀḟ㑻ࠊཎᏕᙪ ᛴᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࢆ≉␗ⓗ࡟Ṛ⁛ࡉࡏࡿ໬ྜ≀ࡢᶆⓗศᏊ᥈⣴➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

3.

Ỉᒸඃ㈗ ࠊ㕥ᮌ㍤ᙪࠊ㐍⸨┿⏤⨾ࠊ໭ᓥ೺஧ࠊཎᏕᙪ Lhx2 ࡀ㐀⾑ᖿ⣽⬊ࢆయእቑᖜࡉ
ࡏࡿศᏊ࣓࢝ࢽࢬ࣒ࡢ᥈⣴ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ－ 96 －

4.

୰ᕝ⨾ᕹ ࠊ✀Ꮚᓥᖾ♸ࠊ୕஭㈗ὒ ࠊᡂ℩බேࠊ㔜Ọ❶ࠊ኱㧘❶ࠊబஂ㛫ၨࠊཎᏕᙪ ࢣࣔ࢝࢖ࣥ CXCL14 ࡢ⬻ෆ࣑ࢡࣟࢢࣜ࢔࡟ᑐࡍࡿാࡁ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍
2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

5.

✀Ꮚᓥᖾ♸ DNA ࡜ CXCL14 ࡟ࡼࡿ⮬↛ච␿⣔ࡢ༠ㄪⓗ࡞ㄪ⠇࣓࢝ࢽࢬ࣒ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ6.

ྜྷ⏣༓⣫ࠊ㖊࿅ెྐࠊᮾᬛஓࠊ୰⏣༓ᑜ ࠊඵᮌᣅဢ ࠊṊᬛ࠶࡙ࡉ ࠊཎᏕᙪࠊ∾ᫀḟ㑻 ᛴ
ᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚไࡍࡿ໬ྜ≀ࡢᵓ㐀άᛶ┦㛵 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

7.

ᮾᬛஓࠊྜྷ⏣༓⣫ࠊ㖊࿅ెྐࠊ୰⏣༓ᑜ ࠊඵᮌᣅဢ ࠊṊᬛ࠶࡙ࡉ ࠊཎᏕᙪࠊ∾ᫀḟ㑻 ᛴ
ᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊࡟ᑐࡍࡿቑṪᢚไάᛶࢆྥୖࡉࡏࡓ໬ྜ≀ࡢ๰〇 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

8.

⚟ᒣ⨾ᬛᏊࠊ஭ཱྀᬛᘯࠊᑠᯇ㇂ၨ௓ࠊᕝᓥ⫱ኵࠊୗ௰ᇶஅࠊ✀Ꮚᓥᖾ♸ࠊཎᏕᙪࠊᒣᮏṇ㞞ࠊ➟ཎᾈ஧ ࢣࣔ࢝࢖ࣥ SDF-1a ࡟ࡼࡿ Jurkat T ⣽⬊⛣ືࡢ⬡㉁ࣛࣇࢺࢆ௓ࡍࡿࢩࢢࢼ
ࣝఏ㐩 ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019.9.18㹼20, ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ

9.

Kosuke TanegashimaࠊTakahiro MitsuiࠊNaoto NaruseࠊKohei TsujiࠊAkira ShigenagaࠊAkira
OtakaࠊTakahiko Hara CXCL14 delivers CpG DNA, and enhances TLR9 signaling in dendritic
cells and macrophages 㑇ఏᏊࢹࣜࣂ࣮ࣜ◊✲఍➨ 19 ᅇࢩ࣏ࣥࢪ࣒࢘ 2019.5.8 ༓ⴥ኱Ꮫ㸪༓ⴥ┴༓ⴥᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 3 ௳㸧
1.

ཎᏕᙪ ୰ኸ኱Ꮫ⌮ᕤᏛ㒊 ㅮ⩏㸦඲ 14 ᅇ㸧2019.4.8~7.15㸪ᮾி㒔ᩥி༊

2.

ཎᏕᙪ 㤳㒔኱Ꮫᮾி኱Ꮫ㝔 ⏕࿨⛉Ꮫ≉ูㅮ⩏ 2019.8.20㸪ᮾி㒔ඵ⋤Ꮚᕷ

3.

ཎᏕᙪ ᮾி㒔໭༊ࡇ࡜ࡪࡁ኱Ꮫ ᣍᚅㅮ₇ 2019.10.8㸪ᮾி㒔໭༊

IV. ≉グ஦㡯࠙≉チฟ㢪ࠚ
1.

ཎᏕᙪࠊᐑୗ࿴ஓࠊඵᮌᣅဢ ࠊṊᬛ࠶࡙ࡉ ࠊ୰⏣༓ᑜ ࠊ∾ᫀḟ㑻ࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊᮾᬛஓ ᛴᛶ㹒ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓ⱝࡋࡃࡣࣜࣥࣃ⭘ࠊཪࡣᛴᛶ㦵㧊ᛶⓑ⾑⑓἞⒪⏝་⸆⤌ᡂ≀ 2019.6.26㸦ฟ㢪␒ྕ 2019-118990㸧

2.

ྠୖ≉チᐇ᪋౛㏣ຍ 2019.12.2㸦ฟ㢪␒ྕ 2019-218270㸧

3.

ཎᏕᙪࠊṊᬛ࠶࡙ࡉ ࠊ୰⏣༓ᑜ ࠊ∾ᫀḟ㑻ࠊྜྷ⏣༓⣫ࠊᮾᬛஓ ᛴᛶⓑ⾑⑓ࡢቑṪࢆ≉␗ⓗ࡟ᢚไࡍࡿపศᏊ໬ྜ≀ࡢ㛤Ⓨ Ⓨ᫂ㄆᐃ 2020.1.21㸦≉チฟ㢪ᶒࡣ㟁㏻኱࡟ᢎ⥅㸧

࠙ࡑࡢ௚ࠚ
1.

ཎᏕᙪ ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔࣭་ṑᏛ⥲ྜ◊✲⛉ 㐃ᦠᩍᤵ㸦ศ㔝㛗㸧
㸦2012 ᖺ 11 ᭶
ࠥ⌧ᅾ㸧

2.

ཎᏕᙪ 㤳㒔኱Ꮫᮾி኱Ꮫ㝔࣭⌮Ꮫ◊✲⛉⏕࿨⛉Ꮫᑓᨷᐈဨᩍᤵ㸦2017 ᖺ 4 ᭶ࠥ⌧ᅾ㸧

3.

ཎᏕᙪ ᮾி㒔໭༊ࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࢫࢡ࣮ࣝ 2019.7.24, ᮾி㒔ୡ⏣㇂༊

4.

ཎᏕᙪ 㤶ᕝ┴❧ほ㡢ᑎ➨୍㧗➼Ꮫᰯ ᮾி◊ಟ 2019.12.12, ᮾி㒔ୡ⏣㇂༊

－ 97 －

ࣉࣟࢪ࢙ࢡࢺྡ

෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Tamura S, Yasuoka Y, Miura H, Takahashi G, Sato M and *Ohtsuka M. Thy1 promoter activity in
the Rosa26 locus in mice: lessons from Dre-rox conditional expression system. Experimental
Animals in press

2.

Fujitani K, Otomo A, Nagayama Y, Tachibana T, Kato R, Kawashima Y, Kodera Y, Kato T, Takada
S, Tamura K, Takamatatsu N and *Ito M. PACT (p53-associated cellular protein testes derived) andp53

regulatetranscriptional

activityof

DMRT1.

Genetics

andMolecular

Biology43:e20190017(2020)
3.

Yamashita S, Kataoka K, Yamamoto H, Kato T, Hara S, Yamaguchi K, Renard-Guillet C, Katou Y,
Shirahige K, Ochi H, Ogino H, Uchida T, Inui M, Takada S, Shigenobu S, and *Asahara H.
Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouseand chicken. Scientific Reports 9:12560 (2019)4.

*Ikeda Y, Kato-Inui T, Tagami A, *Maekawa M. Expression of progesterone receptor, estrogen
receptors Į and ȕ and kisspeptin in the hypothalamus during perinatal development of gonadlacking steroidogenic factor-1 knockout mice. Brain Research 1712:167-179 (2019)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

Yuichiro Miyaoka Genome Editing in Human iPS Cells to Cure and Study Disease, The 4th
TransMed-VN Conference 2019.8.20 Hanoi, Vietnam

ࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

㧗ᶫ๛ࠊ᳃⚽ேࠊ▼㯮᐀ࠊ㇂ෆỤᮃࠊᐑᒸభ୍㑻 CRISPR-Cas12a ࡟ࡼࡿṇ☜࡞Ḟኻኚ␗ᑟධ ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3 ⚟ᒸ┴⚟ᒸᕷ

2.

Gou Takahashi, Hideto Mori, Soh Ishiguro, Nozomu Yachie, Yuichiro Miyaoka Precise Deletion
Mutagenesis by Dual Cas12a DNA Cleavage, Frontiers in Genome Engineering 2019  2019.11.26
රᗜ┴⚄ᡞᕷ

3.

Yuichiro Miyaoka, Kenneth K. B. Tan, Elena Matsa, Steven. J. Mayerl, Amanda H. Chan, Vanessa
Herrera, Aishwarya Kulkarni, Meenakshi Venkatasubramanian, Kashish Chetal, Han Sun, Francesca－ 98 －

Briganti, Wu Wei, Saji Oommen, Daniel F. Carlson, Timothy J. Nelson, Lars Steinmetz, Jay W.
Schneider, Bruce R. Conklin, Nathan Salomonis: Genome-Edited iPSC and Pig Cardiomyopathy
Models Reveal Mutant RBM20 Forms Mislocalized Granules to Dominantly Disrupt Global
Splicing, ISSCR 2019 Annual Meeting4.

2019.6.28, Los Angelsᐑᒸభ୍㑻, Kenneth K. B. Tan, Elena Matsa, Steven. J. Mayerl, Amanda H. Chan, Vanessa
Herrera, Aishwarya Kulkarni, Meenakshi Venkatasubramanian, Kashish Chetal, Han Sun, Francesca
Briganti Francesca, Wu Wei, Saji Oommen, Daniel F. Carlson, Timothy J.Nelson, Lars Steinmetz,
Jay W.Schneider, Bruce R. Conklin, Nathan Salomonis㸸ࢤࣀ࣒⦅㞟 iPS ⣽⬊࠾ࡼࡧࣈࢱࢆ⏝࠸ࡓࢫࣉࣛ࢖ࢩࣥࢢᅉᏊ RBM20 ࡢኚ␗࡟ࡼࡿᚰ➽⑕Ⓨ⑕ᶵᗎࡢゎᯒ ➨ 4 ᅇ᪥ᮏࢤࣀ࣒⦅
㞟Ꮫ఍ᖺ఍ 2019.6.4 ᮾி㒔

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯
࠙ཷ㈹ࠚ
1.

ᐑᒸభ୍㑻 ࠕࢤࣀ࣒ࢆ⦅㞟ࡋࡓ iPS ⣽⬊ࡢຠ⋡ⓗ࡞᳨ฟ࡜༢㞳ᢏ⾡ࡢ◊✲ࠖ࡟ᑐࡋࠊᖹ
ᡂ 31 ᖺᗘ ᩥ㒊⛉Ꮫ኱⮧⾲ᙲ ⱝᡭ⛉Ꮫ⪅㈹ཷ㈹ 2019.4.17

࠙ࡑࡢ௚ࠚ
1.

ᐑᒸభ୍㑻 ࣖࢡࣝࢺ♫Ⓨ⾜ⱥㄒ∧ HEALTHIST ࡢグ஦ࠕGenome Editing and iPS Cells
Opens New Doors in the Life Sciences࡛ࠖ◊✲⤂௓ 2019.11.1

2.

ᐑᒸభ୍㑻 ᪥ᮏࢪ࢙ࢿࢸ࢕ࢡࢫ♫ࡢ࢙࢘ࣈࢧ࢖ࢺ࡛ࠊᑠᏛ⏕ྥࡅ≉ูᤵᴗࠕࡵࡊࡏ DNA
࣐ࢫࢱ࣮㸟ࠖࡢᵝᏊࢆሗ࿌ 2019.8.83.

ᐑᒸభ୍㑻 㞧ㄅ ⮴▱ࡢグ஦ࠕࢤࣀ࣒⦅㞟ࡀᮍ᮶ࢆኚ࠼ࡿ࡛ࠖ◊✲⤂௓ 2019.8.1

4.

ᐑᒸభ୍㑻 㞧ㄅ ㉥ࡕࡷࢇ࡜࣐࣐ࡢࠕ♫఍ࡢࢥࢺࣂࠖ࡜࠸࠺ࢥ࣮ࢼ࣮࡛ࢤࣀ࣒⦅㞟ࢆゎ
ㄝ 2019.7.25

5.

ᐑᒸభ୍㑻 ࣖࢡࣝࢺ♫Ⓨ⾜࣊ࣝࢩࢫࢺࡢ≉㞟ࠕ෌⏕་⒪᭱๓⥺ࠖࡢ୰ࡢグ஦ࠕࠕࢤࣀ࣒
⦅㞟ࠖ࡜ࠕiPS ⣽⬊ࠖࡀ⏕࿨⛉Ꮫࡢ᪂ࡓ࡞ᡬࢆ㛤ࡃ࡛ࠖ◊✲ෆᐜ⤂௓ 2019.7.10

6.

ᐑᒸభ୍㑻 ㄞ኎᪂⪺㛵す∧ࡢグ஦ࠕࢤࣀ࣒⦅㞟ࠕḟୡ௦ iPSࠖࠖ࡟ࢥ࣓ࣥࢺᥖ㍕ 2019.4.5－ 99 －

ࣉࣟࢪ࢙ࢡࢺྡ

⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ

, ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ  ௳㸧࡞ࡋࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 1DNDPXUD$2WDQL.6KLFKLWD7/LSLGPHGLDWRUVDQGVWHULOHLQIODPPDWLRQLQLVFKHPLFVWURNHInt
Immunol  GRLLQWLPPG[DD ὠ ᒣ ῟ ࠊ ୐ ⏣ ᓫ  ⬻ ⹫ ⾑ ᚋ ࡢ ⅖ ⑕ ࡜ ಟ ᚟ ࡟ ࠾ ࡅ ࡿ ⮬ ↛ ච ␿ ࡢ ᙺ ๭ 㸬 ᐇ 㦂 ་ Ꮫ ቑ ห     ୐⏣ᓫ ࣛ࣎ⓒᬒ㸬ᐇ㦂་Ꮫ      ୐⏣ᓫ ຍ㱋࡜⬻⾑⟶㞀ᐖ㸬࢔ࣥࢳ࣭࢚࢖ࢪࣥࢢ་Ꮫ     
 1DNDPXUD.6KLFKLWD7&HOOXODUDQGPROHFXODUPHFKDQLVPVRIVWHULOHLQIODPPDWLRQLQLVFKHPLF
VWURNHJ BiochemSLLPY]   ୰ᮧᖾኴ㑻ࠊ୐⏣ᓫ ⬻᱾ሰᚋ࡟࠾ࡅࡿ↓⳦ⓗ⅖⑕ࡢ࣓࢝ࢽࢬ࣒㸬7KH0W)XML:RUNVKRSRQ
&9'3URFHHGLQJV   ὠ ᒣ ῟ ࠊ ୐ ⏣ ᓫ  ⬻ ⹫ ⾑ ᚋ ࡢ ⅖ ⑕ ࡜ ಟ ᚟ ࡟ ࠾ ࡅ ࡿ ⮬ ↛ ච ␿ ࡢ ᙺ ๭ 㸬 ᐇ 㦂 ་ Ꮫ ቑ ห     ୐⏣ᓫ ຍ㱋࡜⬻⾑⟶㞀ᐖ ࢔ࣥࢳ࣭࢚࢖ࢪࣥࢢ་Ꮫ     ,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧 ୐⏣ᓫ 198 ࡜⅖⑕ 1HXURYDVFXODU XQLW 198  ◊✲఍  ៞᠕⩏ሿ኱Ꮫ་Ꮫ
㒊㸪ᮾி㒔᪂ᐟ༊ ୐⏣ᓫ ⬻༞୰࡜⚄⤒ච␿ ༠࿴࢟ࣜࣥᰴᘧ఍♫ࢭ࣑ࢼ࣮  ༠࿴࢟ࣜࣥᰴᘧ
఍♫◊✲ᡤ㸪㟼ᒸ┴㥴ᮾ㒆 ୐⏣ᓫ ⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕࡜⚄⤒ಟ᚟ ⇃ᮏ኱Ꮫ་Ꮫ㒊ࢭ࣑ࢼ࣮  ⇃ᮏ኱ᏛⓎ⏕་Ꮫ◊✲ᡤ㸪⇃ᮏ┴⇃ᮏᕷ ୐⏣ᓫ 5HODWLRQVKLSVEHWZHHQFHUHEUDOSRVWLVFKHPLFLQIODPPDWLRQDQGQHXUDOUHSDLU ➨  ᅇ᪥ᮏච␿Ꮫ఍  ࢔ࢡࢺࢩࢸ࢕὾ᯇ㸪㟼ᒸ┴὾ᯇᕷ ୐ ⏣ ᓫ  ⬻ ᱾ ሰ ࡟ ࠾ ࡅ ࡿ ᪂ つ '$03V ࡢ ྠ ᐃ   ➨  ᅇ ᪥ ᮏ ⬻ ᚠ ⎔ ௦ ㅰ Ꮫ ఍ ௝ྎỤ㝧ࢢࣛࣥࢻ࣍ࢸࣝ㸪ᐑᇛ┴௝ྎᕷ ୐⏣ᓫ ⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕࡜⚄⤒ಟ᚟ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚ ➨  ᅇ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍
 ௝ྎỤ㝧ࢢࣛࣥࢻ࣍ࢸࣝ㸪ᐑᇛ┴௝ྎᕷ

－ 100 －

 ୐⏣ᓫ ⬻᱾ሰ࡜ච␿ ➨  ᅇ⚄⤒⤌⧊ᇵ㣴◊✲఍  ᮾி኱Ꮫ⸆Ꮫ⣔⥲ྜ◊✲Ჷㅮᇽ㸪ᮾி㒔ᩥி༊ ୐⏣ᓫ ⬻᱾ሰ࡟࠾ࡅࡿ࣑ࢡࣟࢢࣜ࢔ࡢᶵ⬟ゎᯒ ➨  ᅇᐩኈࣇ࢖࣒ࣝ㸫࿴ග࣮࣡ࢡࢩ
ࣙࢵࣉ  ⛅ⴥཎࢥࣥ࣋ࣥࢩ࣮ࣙࣥ࣍ࣝ㸪ᮾி㒔༓௦⏣༊ ୐⏣ᓫ ⬻᱾ሰᚋࡢ↓⳦ⓗ⅖⑕࡜⚄⤒ಟ᚟ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚ ༓ⴥ኱Ꮫ་Ꮫ㒊ࢭ࣑ࢼ࣮
 ༓ⴥ኱Ꮫ㸪༓ⴥ┴༓ⴥᕷ ୐⏣ᓫ ⬻᱾ሰ࡜⅖⑕㹼⚄⤒⤌⧊ࡢಟ᚟࡟ྥࡅࡓศᏊ࣓࢝ࢽࢬ࣒㹼 㛗ᓮ㞀ᐖ⪅ᨭ᥼෌⏕་⒪◊✲఍  㛗ᓮ┴ ὠᒣ῟ࠊ୐⏣ᓫ 5ROH RI LQQDWH P\HORLG FHOOV LQ FHUHEUDO SRVWLVFKHPLF VWHULOH LQIODPPDWLRQ
1(852  ᮒ㮛࣓ࢵࢭ㸪᪂₲┴ ୐⏣ᓫ 7KH UROH RI LQQDWH LPPXQLW\ DQG OLSLG PHWDEROLVP LQ LVFKHPLF VWURNH 1(852
 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴ ୐⏣ᓫ ⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕ࡢศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ ➨  ᅇ᪥ᮏ⅖⑕࣭෌⏕་Ꮫ఍ ⚄ᡞᅜ㝿఍㆟ሙ㸪රᗜ┴⚄ᡞᕷ 6KLFKLWD7 'DPDJHDVVRFLDWHGPROHFXODUSDWWHUQVLQLVFKHPLFVWURNH  %5$,1 %5$,1
 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ ୐⏣ᓫ ⬻⤌⧊ࡢ⹫⾑ቯṚ࡟క࠺⅖⑕࡜ಟ᚟ࡢ࣓࢝ࢽࢬ࣒ ➨  ᅇ᪥ᮏᢠຍ㱋་Ꮫ఍⥲఍  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᕝᓮᕷࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ ୐⏣ᓫ ⬻᱾ሰᚋࡢ↓⳦ⓗ⅖⑕࡜⚄⤒ಟ᚟ ➨  ᅇ᪥ᮏ⏕⌮Ꮫ኱఍ 㹼
ูᗓᅜ㝿ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸪኱ศ┴ูᗓᕷ㸦⣬ୖ㛤ദ㸧 ୰ᮧᖾኴ㑻 '-SOD\VDSLYRWDOUROHLQWKHLQGXFWLRQRIVWHULOHLQIODPPDWLRQDIWHULVFKHPLFVWURNH
➨  ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍ 㹼 ࢔ࢡࢺࢩࢸ࢕὾ᯇ㸪㟼ᒸ┴὾ᯇᕷ ୰ᮧᖾኴ㑻 '- ࡣ⬻᱾ሰ࡟࠾࠸࡚↓⳦ⓗ⅖⑕ࢆᘬࡁ㉳ࡇࡍ᪂つࡢ⅖⑕ច㉳ᅉᏊ࡛࠶ࡿ
➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ㓇஭ㄔ୍㑻ࠊ୐⏣ᓫ 1HXURQDOFLUFXLWUHPRGHOLQJLQWKHQHRFRUWH[DIWHULVFKHPLFVWURNH ࢫࢡࣛࢵࣉ㸤ࣅࣝࢻ࡟ࡼࡿ⬻ᶵ⬟ࡢືⓗไᚚ➨  ᅇ㡿ᇦ఍㆟ 㹼 ࢲ࢖࣡ࣟ࢖ࣖ
ࣝ࣍ࢸࣝ 7+(+$0$1$.2㸪㟼ᒸ┴὾ᯇᕷ ୰ᮧᖾኴ㑻 '- ࡣ⬻᱾ሰ࡟࠾ࡅࡿ᪂つࡢ⅖⑕ច㉳ᅉᏊ࡛࠶ࡿ ࢫࢡࣛࢵࣉ㸤ࣅࣝࢻ࡟ࡼࡿ⬻ᶵ⬟ࡢືⓗไᚚ➨  ᅇ㡿ᇦ఍㆟ 㹼 ࢲ࢖࣡ࣟ࢖ࣖࣝ࣍ࢸࣝ 7+(+$0$1$.2㸪㟼ᒸ┴὾ᯇᕷ ୰ᮧᖾኴ㑻ࠊ㓇஭ㄔ୍㑻ࠊὠᒣ῟ࠊ୐⏣ᓫ '- ࡣ⬻᱾ሰ࡟࠾ࡅࡿ᪂つࡢ⅖⑕ច㉳ᅉᏊ࡛࠶ࡿ ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ྜྠ኱఍  ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ -XQ7VX\DPD 5ROHRIWKHLQQDWHLPPXQHV\VWHPLQFHUHEUDOSRVWLQFKHPLFVWHULOHLQIODPPDWLRQ➨  ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ྜྠ኱఍ 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
 1DNDPXUD . 6DNDL 6 6KLFKLWD 7 '- LV D QRYHO GDPDJHDVVRFLDWHG PROHFXODU SDWWHUQ LQ
LVFKHPLFVWURNH %5$,1 %5$,1  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ 1DNDPXUD$7VX\DPD-6KLFKLWD7 /LSLGPHWDEROLVPLQWKHUHVROXWLRQSKDVHRIFHUHEUDOSRVWLVFKHPLF－ 101 －

LQIODPPDWLRQ %5$,1 %5$,1  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ ୰ᮧᖾኴ㑻ࠊṇ஭ஂ㞝ࠊ୐⏣ᓫ '- ࡣ⬻᱾ሰ࡟࠾ࡅࡿ᪂つࡢ⅖⑕ច㉳ᅉᏊ࡛࠶ࡿ ➨ ᅇᮾி኱Ꮫ⏕࿨⛉Ꮫࢩ࣏ࣥࢪ࣒࢘  ᮾி㒔ᩥி༊,,, ࡑࡢ௚ࡢⓎ⾲㸦 ௳㸧

6HLLFKLUR6DNDLࠊ7DNDVKL6KLFKLWD 5HPRGHOLQJRI1HXURQDO&RQQHFWLYLW\LQWKH1HRFRUWH[DIWHU
,VFKHPLF6WURNH ➨  ᅇග᧯స◊✲఍ 㹼 ྡྂᒇᕤᴗ኱Ꮫ  ྕ㤋࣮࣍ࣝ㸪ឡ▱┴ྡྂᒇᕷ ୰ᮧᖾኴ㑻 ⣽⬊እࡢ '- ࡣ⬻᱾ሰ࡟࠾࠸࡚↓⳦ⓗ⅖⑕ࢆច㉳ࡍࡿ ➨  ᅇච␿㐺ሿ㹼 ࢫࢱ࣮ࢶ⥲ྜ◊ಟࢭࣥࢱ࣮㸪Ⲉᇛ┴ࡘࡃࡤᕷ ୰ᮧᖾኴ㑻ࠊ㓇஭ㄔ୍㑻ࠊὠᒣ῟ࠊ୐⏣ᓫ ,GHQWLI\LQJQRYHOIXQFWLRQRI'-DVLQIODPPDWLRQLQGXFLQJIDFWRUDIWHULVFKHPLFVWURNH ᪂Ꮫ⾡㡿ᇦࢫࢡࣛࢵࣉ ࣅࣝࢻ࡟ࡼࡿ⬻ᶵ⬟ࡢືⓗไᚚ ➨ᅄᅇ⌜఍㆟  㟼ᒸ┴὾ᯇᕷ 㓇஭ㄔ୍㑻ࠊ୐⏣ᓫ 1HXURQDOFLUFXLWUHPRGHOLQJLQWKHQHRFRUWH[DIWHULVFKHPLFVWURNH ᪂Ꮫ⾡㡿ᇦࢫࢡࣛࢵࣉ ࣅࣝࢻ࡟ࡼࡿ⬻ᶵ⬟ࡢືⓗไᚚ ➨ᅄᅇ⌜఍㆟  㟼ᒸ┴὾ᯇᕷ ୰ᮧᖾኴ㑻ࠊ୐⏣ᓫ '- ࡣ⬻᱾ሰ࡟࠾ࡅࡿ᪂つࡢ⅖⑕ច㉳ᅉᏊ࡛࠶ࡿ 72%,5$ ➨ ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛ  ᮾி㒔,9 ≉グ஦㡯
࠙ཷ㈹ࠚ
୐⏣ᓫ
 06' ◊✲ຓᡂʊ᭱ඃ⚽㈹ཷ㈹ 㸦06' ⏕࿨⛉Ꮫ㈈ᅋ ◊✲ຓᡂ  㡿ᇦྜྠ◊✲Ⓨ⾲఍㸧
୰ᮧᖾኴ㑻  ᭱ඃ⚽࣏ࢫࢱ࣮㈹ 㸦᪂Ꮫ⾡㡿ᇦࢫࢡࣛࢵࣉ ࣅࣝࢻ࡟ࡼࡿ⬻ᶵ⬟ࡢືⓗไᚚ ➨ᅄᅇ⌜఍㆟㸧 ඃ⚽Ⓨ⾲㈹ 㸦1HXUR㸧
 <RXQJ,QYHVWLJDWRU$ZDUG 㸦➨  ᅇᅜ㝿࣐ࢡࣟࣇ࢓࣮ࢪᏛ఍㸧  ඃ⚽࣏ࢫࢱ࣮㈹ 㸦➨  ᅇᮾி኱Ꮫ⏕࿨⛉Ꮫࢩ࣏ࣥࢪ࣒࢘㸧 ୰ᮧᮒ㔛 ඃ⚽Ⓨ⾲⪅㈹ 㸦ᡤෆ◊✲Ⓨ⾲఍➨  㒊఍㸧 
－ 102 －

ࣉࣟࢪ࢙ࢡࢺྡ

㐠ື㞀ᐖࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Honda T, Mitoma H, Yoshida H, Bando K, Terashi H, Taguchi T, Miyata Y, Kumada S, Hanakawa
T, Aizawa H, Yano S, Kondo T, Mizusawa H, Manto M, *Kakei S. Assessment and rating of motor
cerebellar ataxias with the Kinect v2 depth sensor: Extending our appraisal. Front Nueurol,
11:179 (2020)

2.

*Kakei S, Lee J, Mitoma H, Tanaka H, Manto M, Hampe CS. Contribution of the cerebellum topredictive motor control and its evaluation in ataxic patients. Front Hum Neurosci, 13:216 (2019)3.

Tanaka H, Ishikawa T, *Kakei S. Neural evidence of the cerebellum as a state predictor.
Cerebellum, 18:349-371 (2019)4.

*Kakei S, Ishikawa T, Lee J, Honda T, Hoffman DS. Physiological principles of the cerebellar
reserve. In Eds. Mitoma H and Mario M.

Special Issue for CNS & Neurological Disorders –Drug Targets, 17:184-192 (2018)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 5 ௳㸧
1.

Tanaka H, Ishikawa T, Lee J, *Kakei S. The cerebro-cerebellum as loci of forward models: a
review. Front Syst Neurosci, 14:19. (2020) ⥲ㄝㄽᩥ㸪ᰝㄞ࠶ࡾ

2.

*⟍ៅ἞ ࠕື≀ࡢ㎡඾ࠖ➨ 8 ❶ ື≀ࡢ⬻࣭⚄⤒⣔ ➨ 4 ⠇ ⬻ࡢാࡁ 8.4.1 㐠ືไᚚ(in press) ᰝㄞ࡞ࡋ3.

*⟍ៅ἞ࠊᮏከṊᑛࠊᮤ㙂ᪿࠊྜྷ⏣኱ᓠࠊΏ㒊㞞ஓࠊ㏆⸨ᩄஅࠊ୕Ɫ༤ࠊỈ⃝ⱥὒࠕᑠ⬻ኻㄪࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ་⒪ʊୖ⫥࡟ࡘ࠸࡚ࠖJap J Rehab Med 56(2):94-100(2019)ᰝㄞ࡞ࡋ

4.

*⟍ៅ἞ࠊᮏከṊᑛࠊᮤ㙂ᪿࠊྜྷ⏣኱ᓠࠊΏ㒊㞞ஓࠊ㏆⸨ᩄஅࠊ୕Ɫ༤ࠊỈ⃝ⱥὒ. Clinical
Neuroscience , 37(8): 965-968 (2019)ᰝㄞ࡞ࡋ

5.

*Kakei S and Mizusawa H. (Editors) “Cerebellum as a CNS Hub” Springer (in press)ᰝㄞ࠶ࡾ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 7 ௳㸧
1.

⟍ៅ἞ 㐠ືኻㄪ⑕ࡢホ౯ᣦᶆ SARA ࡢࢹࢪࢱࣝ໬࡟ࡼࡿᑠ⬻ᶵ⬟ホ౯ࡢ㧗⢭ᗘ໬ ➨49 ᅇ᪥ᮏ⮫ᗋ⚄⤒⏕⌮Ꮫ఍࣭බເࢩ࣏ࣥࢪ࣒࢘ࠕᑠ⬻ᶵ⬟ࡢⰍࠎ࡞࡜ࡽ࠼࠿ࡓࠖㅮ₇
2019.11.28 ࢥࣛࢵࢭࡩࡃࡋࡲ㸪⚟ᓥ┴⚟ᓥᕷ

2.

⟍ៅ἞ ࠿ࡽࡔࡢືࡁࡢศᯒ࠿ࡽ⬻ࡢാࡁࢆ▱ࡿࡇࡇࢁࡳ ᪥ᮏᑠඣ⚄⤒Ꮫ఍࣭➨ 49 ᅇᑠඣ⚄⤒Ꮫࢭ࣑ࢼ࣮ᩍ⫱ㅮ₇ 2019.11.16 ࣓࢖ࣉࣝ࢖ࣥᖥᙇ㸪༓ⴥ┴༓ⴥᕷ

3.

⟍ៅ἞ ℩ᕝグᛕᑠඣ⚄⤒Ꮫࢡࣜࢽࢵࢡࢭ࣑ࢼ࣮ 2019.10.18 ℩ᕝグᛕᑠඣ⚄⤒Ꮫࢡࣜࢽࢵࢡ㸪ᮾி㒔༓௦⏣༊

－ 103 －

4.

⟍ៅ἞ ᪥ᮏ⚄⤒⌮Ꮫ⒪ἲᏛ఍⥲఍ᇶㄪㅮ₇ 2019.10.13 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ5.

ᮏከṊᑛ ᪥ᮏ⚄⤒⛉Ꮫ఍⥲఍࣭බເࢩ࣏ࣥࢪ࣒࢘ㅮ₇ 2019.9.15 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ

6.

Kakei S.

“Neural evidence of the cerebellum as a state predictor” ⱥᅜ Sheffield ኱Ꮫᣍᚅㅮ₇

University of Sheffield
7.

Kakei S.

2019.5.24“Neural evidence of the cerebellum as a state predictor” ⱥᅜ Bristol ኱Ꮫ≉ูᣍᚅㅮ

₇ University of Bristol 2019.5.19
ࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
1.

Kakei S.

“Neural evidence of the cerebellum as a state predictor” 10th International Symposiumof the Society for Research on the Cerebellum (SRCA), UK, May 24-26, 2019.5.26

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1.

⟍ៅ἞ ᫛࿴㡢ᴦ኱Ꮫ࣭2019 ᖺᗘ≉ูㅮᗙ 2019.6.1 ᫛࿴㡢ᴦ኱Ꮫ㸪⚄ዉᕝ┴ᕝᓮᕷ

IV. ≉グ஦㡯1.

⡿ᅜ≉チⓏ㘓࠙Ⓨ᫂⪅ࠚ⟍ៅ἞ࠊᮤ㙂ᪿࠊ⧊ⱱᬛஅࠊ✄ⴥᙲࠊᒸ⏣Ᏻᘯ࠙Ⓨ᫂ࡢྡ⛠ࠚ
Motor function analysis system and operational method of system࠙≉チⓏ㘓᪥ࠚJun. 25, 2019࠙≉チ␒ྕࠚ US 10,327,675 B2－ 104 －

ࣉࣟࢪ࢙ࢡࢺྡ

どぬ⑓ែࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

Namekata, K., Guo, X., Kimura, A., Arai, N., Harada, C. and *Harada, T. DOCK8 is expressed in
microglia, and it regulates microglial activity during neurodegeneration in murine disease models.
Journal of Biological Chemistry 294(36), 13421-13433, 2019.

2.

Noro, T., Namekata, K., Kimura, A., Azuchi, Y., Hashimoto, N., Moriya-Ito, K., Komaki, Y., Lee,
C.Y., Okahara, N., Guo, X., Harada, C., Kim, E., Nakano, T., Tsuneoka, H., Inoue, T., Sasaki, E.,
Tokuno, H. and *Harada, T. Normal tension glaucoma-like degeneration of the visual system inaged marmosets. Scientific Reports 9, 14852, 2019.

3.

Honda, S., *Namekata, K., Kimura, A., Guo, X., Harada, C., Murakami, A., Matsuda, A. andHarada, T. Survival of alpha and intrinsically photosensitive retinal ganglion cells in
NMDA-induced neurotoxicity and a mouse model of normal tension glaucoma. Investigative
Ophthalmology & Visual Science 60(12), 3696-3707, 2019.

4.

Sano, H., *Namekata, K., Kimura, A., Shitara, H., Guo, X., Harada, C., Mitamura, Y. and Harada,
T. Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal
tension glaucoma. Cell Death and Disease 10(2), 75, 2019.

5.

Wiltrout, K., Ferrer, A., van de Laar, I., Namekata, K., Harada, T., Klee, E.W., Zimmerman, M.T.,
Cousin, M.A., Kempainen, J.L., Babovic-Vuksanovic, D., van Slegtenhorst, M., Aarts-Tesselaar,
C.D., Schnur, R.E., Andrews, M. and *Shinawi, M. Variants in DOCK3 cause developmental delay
and hypotonia. European Journal of Human Genetics 27(8), 1225-1234, 2019.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 4 ௳㸧
1.

Harada, C., Kimura, A., Guo, X., Namekata, K. and *Harada, T. Recent advances in geneticallymodified animal models of glaucoma and their roles in drug repositioning. British Journal of
Ophthalmology 103(2), 161–166, 2019.㸦ᰝㄞ࠶ࡾ㸧

2.

*Kimura, A., Noro, T. and Harada, T. Role of animal models in glaucoma research. Neural
Regeneration Research 15, 1257-1258, 2020.㸦ᰝㄞ࠶ࡾ㸧3.

㔝࿅㝯ᙪࠊ*ཎ⏣㧗ᖾ. ど⚄⤒࡜෌⏕་⒪. ᪥ᮏࡢ║⛉ 91(2), 24-28, 2020.

4.

*ཎ⏣㧗ᖾ. ╧╀᫬↓࿧྾⑕ೃ⩌࡟࠾ࡅࡿ⥳ෆ㞀Ⓨ⑕ࣜࢫࢡ. THE LUNG perspectivesࠕ╧╀᫬↓࿧྾⑕ೃ⩌㸸ᇶ♏࠿ࡽ⮫ᗋࠖ28(1), 46-48, 2020.

－ 105 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 3 ௳㸧
1.

ཎ⏣㧗ᖾ ⥳ෆ㞀἞⒪࡬ࡢ᪂ࡓ࡞࢔ࣉ࣮ࣟࢳࠕ⥳ෆ㞀἞⒪ࡢ᪂ࡓ࡞ኪ᫂ࡅࠖ ➨ 39 ᅇ᪥ᮏ║⸆⌮Ꮫ఍ 2019.9.15 ྡྂᒇᕷ❧኱Ꮫ⑓㝔኱࣮࣍ࣝ㸪ឡ▱┴ྡྂᒇᕷ2.

ཎ⏣㧗ᖾ ど⚄⤒ಖㆤࢆ┠ᣦࡋࡓ⸆๣࢔ࣉ࣮ࣟࢳ ➨ 6 ᅇ Japan ROCK Conference
2019.8.24 ⯆࿴ᰴᘧ఍♫ᮾிᨭᗑ኱࣮࣍ࣝ㸪ᮾி㒔୰ኸ༊

3.

ཎ⏣㧗ᖾ ⥳ෆ㞀἞⒪࡬ࡢ᪂ࡓ࡞࢔ࣉ࣮ࣟࢳ Mie Ophthalmic Vision 㸤 Eye care seminar
4th 2020.2.16 ᅄ᪥ᕷ㒔࣍ࢸࣝ, ୕㔜┴ᅄ᪥ᕷᕷࡑࡢ௚ 㸦ィ 6 ௳㸧⮬⏤ᥖ㍕
1.

໭ᮧ⿱ኴࠊ⾜᪉࿴ᙪࠊᮌᮧᩔᏊࠊ㒌ᬡ㯇ࠊᒣᮏಟ୍ࠊཎ⏣㧗ᖾ AAV-TrkB ᢞ୚࡟ࡼࡿ⥙⭷⚄⤒⠇⣽⬊ᶞ≧✺㉳ࡢಖㆤຠᯝ ➨ 30 ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍ 2019.9.6 ࣍ࢸࣝ᪥⯟⇃ᮏ㸪⇃ᮏ┴⇃ᮏᕷ

2.

㔠⩏㐨ࠊ⾜᪉࿴ᙪࠊᮏ⏣⣪㔛ࠊ㒌ᬡ㯇ࠊᮌᮧᩔᏊࠊ୰㔝໷ࠊཎ⏣㧗ᖾ ࢔ࢹࣀ㝶క࢘࢖ࣝࢫࢆ⏝࠸ࡓάᛶᆺ TrkA ࡟ࡼࡿ⚄⤒ಖㆤ࡜ど⚄⤒㍈⣴ࡢ෌⏕ຠᯝ ➨ 30 ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍
2019.9.6 ࣍ࢸࣝ᪥⯟⇃ᮏ㸪⇃ᮏ┴⇃ᮏᕷ

3.

Honda S, Namekata K, Kimura A, Guo X, Matsuda A, Murakami A, Harada T. Survival of ĮRGCand ipRGC in a mouse model of glaucoma.  ARVO Annual Meeting 2019  2019.4.28
Vancouver, Canada

4.

ᮏ⏣⣪㔛ࠊ⾜᪉࿴ᙪࠊᮌᮧᩔᏊࠊ㒌ᬡ㯇ࠊᯇ⏣ᙲࠊᮧୖᬗࠊཎ⏣㧗ᖾ ⥳ෆ㞀ࣔࢹ࣐ࣝ࢘
ࢫ࡟࠾ࡅࡿ ĮRGC ࠾ࡼࡧ ipRGC ࡢ㞀ᐖ⪏ᛶ ➨ 123 ᅇ᪥ᮏ║⛉Ꮫ఍⥲఍ 2019.4.21 ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊5.

㔠⩏㐨ࠊᮏ⏣⣪㔛ࠊᏳᅵࡺࡾᏊࠊ㒌ᬡ㯇ࠊᮌᮧᩔᏊࠊ⾜᪉࿴ᙪࠊ୰㔝໷ࠊཎ⏣㧗ᖾ άᛶᆺ TrkB ࢆ⏝࠸ࡓ㑇ఏᏊ἞⒪࡟ࡼࡿ⚄⤒ಖㆤ࡜ど⚄⤒㍈⣴ࡢ෌⏕ຠᯝ ➨ 123 ᅇ᪥ᮏ║⛉Ꮫ఍⥲఍ 2019.4.21 ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊

6.

బᇣᘯᶞࠊ⾜᪉࿴ᙪࠊᮌᮧᩔᏊࠊ㒌ᬡ㯇ࠊཎ⏣▱ຍᏊࠊ୕⏣ᮧె඾ࠊཎ⏣㧗ᖾ 㸰✀㢮ࡢ⥳ෆ㞀ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ N-acetylcysteine ࡢ␗࡞ࡿ⚄⤒ಖㆤຠᯝ ➨ 123 ᅇ᪥ᮏ║⛉Ꮫ఍⥲఍ 2019.4.21 ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯1.

ཎ⏣㧗ᖾ ➨ 30 ᅇ᪥ᮏ⥳ෆ㞀Ꮫ఍㸦2019.9.6㹼9.8㸧࠾ࡼࡧ➨ 73 ᅇ᪥ᮏ⮫ᗋ║⛉Ꮫ఍
㸦2019.10.24㹼10.27㸧࡛ᗙ㛗ࢆᢸᙜ

－ 106 －

ࣉࣟࢪ࢙ࢡࢺྡ

㞴⑓ࢣ࢔┳ㆤࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 7 ௳㸧
1.

Cazzolli A, Brooks B, Nakayama Y, Lewarski J, McKim D, Holt S and Chatburn R. The Oral
Secretion Scale and Prognostic Factors for Survival in Subjects With Amyotrophic Lateral
Sclerosis . Respiratory Care March 2020, respcare.07005; DOI: 10.4187/respcare.07005 (2020.3)

2.

ᑠᕝ୍ᯞࠊᶫᮏⱥᏊࠊ๓ᕝ࠶ࡺࡳࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊ୰ᒣඃᏘ ᮾி㒔⚄⤒㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡ஦ᴗ࡟࠾ࡅࡿ㞴⑓་⒪ᑓ㛛ဨࡢάືࢆ࡜࠾ࡋࡓᨭ᥼⪅ᨭ᥼. ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ఍ㄅ Vol.6,p41-46,2020.1㸦➨㸳ᅇᏛ⾡㞟఍ඃ⚽ཱྀ₇㈹㸧
3.

Nakayama Y, *Shimizu T, Matsuda C, Haraguchi M, Hayashi K, Bokuda K, Nagao M, Kawata A,,VKLNDZDဩ7DNDWD . ,VR]DNL ( %RG\ ZHLJKW YDULDWLRQ SUHGLFWV GLVHDVH SURJUHVsion after invasive
ventilation in amyotrophic lateral sclerosis. Scientific Reports volume 9, Article number: 12262(2019) s41598-019-48831-9

4.

*Shimizu T, Nakayama Y, Matsuda C, Haraguchi M, Bokuda K, Ishikawa-Takata K, Kawata A,
Isozaki E. Prognostic significance of body weight variation after diagnosis in ALS: a single-centre
prospective study. J Neurol 2019;266:1412-1420. doi: 10.1007/s00415-019-09276-2.

5.

Shimizu T, Nakayama Y, Funai A, Morishima R, Hayashi K, Bokuda K, Nakata Y, Isozaki E.
Progressive deterioration of sensory cortex excitability in advanced amyotrophic lateral sclerosis
with invasive ventilation. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
published on line 18 Dec http://dx.doi.org/10.1080/21678421.2019.1704015

6.

Bokuda K, *Shimizu T, Kimura H, Morishima R, Kamiyama T, Kawata A, Nakayama Y, Isozaki E.
Relationship between EMG-detected and ultrasound-detected fasciculations in amyotrophic lateralsclerosis:aprospective

cohortstudy.

Clin Neurophysiol

2019;

early

online.

doi:

10.1016/j.clinph.2019.08.017
7.

Matsuda C, Shimizu T, Nakayama Y, Haraguchi M. Cough peak flow decline rate predicts survival
in patients with amyotrophic lateral sclerosis, Muscle Nerve, 59:168-173. 2019.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 14 ௳㸧
1.

Ideguchi N, Nakayama Y, Nakajima T. Patient-based quality of life(QoL) measurement using the
Schedule for the Evaluation of Individual QoL (SEIQoL) and response shift. The SHOWAUNIVERSITY JOURNAL OF MEDICAL SCIENCES 31 (1),93-99,2019㸦ᰝㄞ࡞ࡋ㸧

2.

୰ᒣඃᏘ㸦⥲ㄝ㸧≉㞟 ᅾᏯ་⒪࡛ࡼࡃ⾜࠺་⒪ᡭᢏࢆ෌⪃ࡍࡿ㸟 ᅾ Ꮿ᪂⒪ 4(8),748756,2019㸦ᰝㄞ࡞ࡋ㸧3.

ཎཱྀ㐨Ꮚࠊ➟ཎᗣ௦ࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊ ┳ㆤ⫋࡜௓ㆤ⫋ࡢ㐃ᦠ࡟ࡼࡿᅾᏯ⒪㣴ᨭ᥼ࣜࢫࢡ⟶⌮ࢶ࣮ࣝࡢ㛤Ⓨ. ་⒪࡜Ᏻ඲ , 2019. 10: 35-44㸦ᰝㄞ࡞ࡋ㸧

4.

୰ᒣඃᏘ㸦ศᢸᇳ➹㸧ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ㞀ᐖ ⚄⤒⑌ᝈࡢ⦆࿴ࢣ࢔ Ⲷ㔝⨾ᜨᏊ࡯࠿ ༡－ 107 －

ᒣᇽ 191-192,
5.

⥲࣮࣌ࢪ 364.

ᯇ⏣༓᫓㸦ศᢸᇳ➹㸧ṑ⛉ཱྀ࣭⭍⾨⏕ ⚄⤒㞴⑓㡿ᇦࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᐇ㊶࢔ࣉ࣮ࣟࢳ  ⏣୰ຬḟ㑻ࠊ༡㞼ᾈ㝯ࠊᮃ᭶ஂࠊᑠ᳃ဴኵ⦅㞟 ࣓ࢪ࢝ࣝࣅ࣮ࣗ♫ 136㸫152
6.

ཎཱྀ㐨Ꮚ 㞴⑓ಖ೺άື. ಖ೺ᖌᅜᐙヨ㦂ࡢࡓࡵࡢࣞࣅ࣮ࣗࣈࢵࢡ 2020 ➨ 20 ∧: 151-156.
ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔

7.

ཎཱྀ㐨Ꮚ 㞴⑓ಖ೺άື ࢡ࢚ࢫࢳ࣭ࣙࣥࣂࣥࢡಖ೺ᖌᅜᐙヨ㦂ၥ㢟ゎㄝ 2020 ➨ 12 ∧
307-321. ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔

8.

୰ᒣඃᏘ*ࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊ 㞴⑓࡟࠾ࡅࡿ┳ㆤᖌࡢᙺ๭ 㹼ᅾᏯ⒪㣴ᨭ᥼ࠊ≉࡟ேᕤ࿧྾ჾ౑⏝⪅࡬ࡢゼၥ┳ㆤᥦ౪ࡢどⅬ࠿ࡽ㹼2019 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩

9.

୰ᒣඃᏘ*ࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊᑠ᳃ဴኵ ேᕤ࿧྾ჾ౑⏝㞴⑓ᝈ⪅࡬ࡢゼၥ┳ㆤ࡟㛵ࡍࡿㄪᰝ㸫ᅾᏯேᕤ࿧྾ჾ౑⏝ᝈ⪅ᨭ᥼஦ᴗ฼⏝ᝈ⪅࡜ᥦ౪ゼၥ┳ㆤ஦ᴗᡤࡢศᯒ㸫2019 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩10. ཎཱྀ㐨Ꮚ㸦⦅㞟࣭ศᢸᇳ➹ᢸᙜ㸧ၻ⑱྾ᘬࡢࢣ࢔ᐇ᪋ࡢᡭᘬࡁ ⤒⟶ᰤ㣴ࡢࢣ࢔ᐇ᪋ࡢᡭᘬࡁ ᭱᪂௓ㆤ⚟♴ኈ㣴ᡂㅮᗙ 15 ་⒪ⓗࢣ࢔௓ㆤ⚟♴ኈ㣴ᡂㅮᗙ, 223㹼283 ୰ኸἲつฟ∧
11. ཎཱྀ㐨Ꮚ*ࠊ୰ᒣඃᏘࠊᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ 㞴⑓ࡢከ⫋✀㐃ᦠ◊ಟ㸫㞴⑓ᝈ⪅➼࣮࣒࣍࣊ࣝࣃ࣮㣴ᡂ◊ಟࡢᐇ᪋≧ἣ࣭㞴⑓ከ⫋✀㐃ᦠ◊ಟࡢホ౯㸫 2019 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩12. ཎཱྀ㐨Ꮚ㸦ጤဨ㛗㸧 ௧࿴ඖᖺᗘ⪁ேಖ೺஦ᴗ᥎㐍㈝➼⿵ຓ㔠⪁ேಖ೺೺ᗣቑ㐍➼஦ᴗၻ⑱྾ᘬ➼ࡢᏳ඲࡞ᐇ᪋ࡢ᥎㐍࡟㛵ࡍࡿㄪᰝ◊✲஦ᴗሗ࿌᭩ ୕⳻ UFJ ࣜࢧ࣮ࢳ㸤ࢥࣥࢧࣝࢸ࢕ࣥࢢ
13. ᑠ಴ᮁᏊࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ➟ཎᗣ௦ࠊ୰ᒣඃᏘ 2019 ௒ࠊಖ೺ᖌࡔ࠿ࡽ
࡛ࡁࡿࡇ࡜㸟ྛᆅࡢ࡜ࡾࡃࡳ࡟Ꮫࡪ㸪2019 ᖺᗘཌ⏕ປാᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸧㞴⑓ಖ೺άືࡢ᥎㐍࡟㛵ࡍࡿศᢸ◊✲ሗ࿌᭩, 2020
14. ᑠ಴ᮁᏊࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ➟ཎᗣ௦ࠊ୰ᒣඃᏘ 㒔㐨ᗓ┴ࠊಖ೺ᡤタ⨨ᕷཬࡧ≉ู༊࡟࠾ࡅࡿࠕ㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ࠖࢆྵࡴ㞴⑓ᝈ⪅ᆅᇦᨭ᥼ᑐ⟇᥎㐍஦ᴗ࠾ࡼࡧ㞴⑓ಖ೺άື࣭◊ಟࡢయไ㸪2019 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 5 ௳㸧
1.

ཎཱྀ㐨Ꮚ 㞴⑓ከ⫋✀㐃ᦠࡢ࡞࠿࡛ồࡵࡽࢀࡿࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ ➨ 3 ᅇ᪥ᮏࣜࣁࣅ
ࣜࢸ࣮ࢩࣙࣥ་Ꮫ఍⛅ᏘᏛ⾡㞟఍ྜྠࢩ࣏ࣥࢪ࣒࢘ 2019.11.16 㟼ᒸ┴ࢥࣥ࣋ࣥࢩࣙࣥ
࢔࣮ࢶࢭࣥࢱ࣮ࢢࣛࣥࢩࢵࣉ㸪㟼ᒸ┴㟼ᒸᕷ

2.

୰ᒣඃᏘ ALS ࡢ࿧྾⟶⌮ ึᮇ࠿ࡽࡣࡌࡵࡿ࿧྾ࢣ࢔㹼ඛࢆࡳࡍ࠼ࠊࡑ࡞࠼ࡿࡓࡵ࡟㹼➨ 29 ᅇ᪥ᮏ࿧྾ࢣ࢔࣭ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍Ꮫ⾡㞟఍ 2019.11.11㹼11.12 ྡྂᒇᅜ㝿఍㆟ሙ㸪ឡ▱┴ྡྂᒇᕷ－ 108 －

3.

୰ᒣඃᏘ ࣓ࢹ࢕࢝ࣝࢫࢱࢵࣇࣞࢡࢳ࣮ࣕ⚄⤒㞴⑓࡜⒪㣴ᨭ᥼ࡢ⌧≧࡜௒ᚋࡢㄢ㢟㹼⒪㣴⾜⛬ࡢక㉮⪅࡜ࡋ࡚㹼 ➨ 37 ᅇ᪥ᮏ⚄⤒἞⒪Ꮫ఍Ꮫ⾡㞟఍ 2019.11.5㹼11.7 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ

4.

Nakayama Y. Innovation of Home-Monitoring-Based Telenursing: The Evidence and Challenging
for Health Policy Changes in Japan, 2019 BK21PLUS International Symposium Health and Carein Aging Asian Cities: Can Big Data and Technology Help? 2019.10.30 Seoul, Korea.

5.

୰ᒣඃᏘ ALS ࡟࠾ࡅࡿ༠ാពᛮỴᐃ 㹼 ࡺࡽࡄẼᣢࡕ࡜ྥࡁྜ࠺ 㹼ALS ᅾᏯேᕤ࿧
྾⒪ἲࡢ⌧≧࡜ㄢ㢟- 㞴⑓ࢣ࢔┳ㆤࡢどⅬ࠿ࡽ ➨ 1 ᅇ᪥ᮏᅾᏯ་⒪㐃ྜᏛ఍኱఍
2019.7.14 ி⋤ࣉࣛࢨ࣍ࢸࣝ㸪ᮾி㒔᪂ᐟ༊ࡑࡢ௚ 㸦ィ 18 ௳㸧⮬⏤ᥖ㍕
1.

ཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊ ᅾᏯ⒪㣴ᨭ᥼࡟࠾ࡅ
ࡿᏳ඲⟶⌮㸫ゼၥ┳ㆤ஦ᴗᡤ࣭ゼၥ௓ㆤ஦ᴗᡤࡢᐇែ㸫 ➨ 6 ᅇ᪥ᮏ་⒪Ᏻ඲Ꮫ఍Ꮫ⾡㞟఍ 2020.3.27㹼4.2 ࢖ࣥࢱ࣮ࢿࢵࢺ㛤ദ

2.

ᯈᇉࡺࡳࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊ 㞴⑓ᝈ⪅ࡢゼၥ┳ㆤ฼⏝ࡢ⌧≧࡜ㄢ㢟 ➨ 9 ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍ 2019.12.8 ᮾி㒔┳ㆤ༠఍఍㤋㸪ᮾ
ி㒔᪂ᐟ༊

3.

ཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊ ゼၥ௓ㆤ⫋ဨ࡟ࡼࡿゼၥ┳ㆤᖌ࡜ࡢ㐃ᦠ࡟㛵ࡍࡿᐇែ ➨ 9 ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍ 2019.12.8 ᮾி㒔┳ㆤ༠఍఍㤋㸪ᮾி㒔᪂ᐟ༊

4.

ᯇ⏣༓᫓ࠊཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊ ㄆ▱⑕ࢆక࠺➽ⴎ⦰ᛶഃ⣴◳໬⑕㸦ALS-D㸧ᝈ⪅ࡀ඲᪥㠀౵くⓗேᕤ࿧྾࡜࡞ࡿࡲ࡛ࡢ⒪㣴⾜⛬ ➨ 9 ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍ 2019.12.7 ᮾி㒔┳ㆤ༠఍఍㤋㸪ᮾி㒔᪂ᐟ༊

5.

୰ᒣඃᏘࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊࠊᐑཎ⯙ࠊᑠ᳃ဴኵ 㞴⑓ᝈ⪅ࡢ⏕άᐇែㄪᰝ㹼⤒㐣ᥐ⨨⤊஢๓ᚋ࡛ࡢ㏻㝔㢖ᗘࡢኚ໬࡜ࡑࡢせᅉ㹼 ➨ 7 ᅇ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ఍Ꮫ⾡㞟఍ 2019.11.16 ஑ᕞ኱Ꮫ་Ꮫ㒊ⓒᖺㅮᇽ㸪⚟ᒸ┴⚟ᒸᕷ6.

ᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊཎཱྀ㐨ᏊࠊΎỈಇኵࠊእ᮶㏻㝔ᮇ࡟࠶ࡿㄆ▱⑕ࢆక࠺➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ 2 ౛ࡢ⌫㯞⑷⑕≧࡜࿧྾㞀ᐖࡢ㛵ಀ ➨ 15 ᅇ᪥ᮏ⚄⤒➽⑌ᝈᦤ㣗࣭ᄟୗ࣭ᰤ
㣴◊✲఍Ꮫ⾡㞟఍ 2019.10.19 㛗Ⰻᕝᅜ㝿఍㆟ሙ㸪ᒱ㜧┴ᒱ㜧ᕷ7.

ΎỈಇኵࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊཎཱྀ㐨Ꮚࠊᯘ೺ኴ㑻ࠊᮌ⏣⪔ኴࠊ㛗ᑿ㞞⿱ࠊᕝ⏣᫂ᗈࠊ㧗⏣࿴Ꮚࠊ☾ᓮⱥ἞ ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿయ㔜ῶᑡ࡜࿧྾ჾ⿦╔ᚋࡢᶵ⬟ணᚋ➨ 15 ᅇ᪥ᮏ⚄⤒➽⑌ᝈᦤ㣗࣭ᄟୗ࣭ᰤ㣴◊✲఍Ꮫ⾡㞟఍ 2019.10.19 㛗Ⰻᕝᅜ㝿఍㆟ሙ㸪ᒱ㜧┴ᒱ㜧ᕷ

8.

➟ཎᗣ௦ࠊ୰ᒣඃᏘࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊ 㞴⑓ἲ᪋⾜࡟క࠺ᝈ⪅ࡢ⏕άᐇែ࡜ᨭ᥼᪉⟇ࡢ᳨ウ ➨ 24 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍Ꮫ⾡㞟఍ 2019.8.24 ᒣᙧ┴❧ಖ
೺་⒪኱Ꮫ㸪ᒣᙧ┴ᒣᙧᕷ

9.

ᯈᇉࡺࡳࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊࠊᑠ᳃ဴኵ ᅾᏯேᕤ࿧྾ჾ౑⏝㞴⑓ᝈ⪅ᨭ᥼஦ᴗࡢ฼⏝≧ἣ࡜ᥦ౪ࡉࢀࡓ┳ㆤෆᐜ ➨ 24 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍Ꮫ⾡㞟఍
2019.8.24 ᒣᙧ┴❧ಖ೺་⒪኱Ꮫ㸪ᒣᙧ┴ᒣᙧᕷ

10. ᮌ඲┿⌮ࠊཎཱྀ㐨Ꮚࠊᯈᇉࡺࡳࠊ୰ᒣඃᏘ ⚄⤒㞴⑓ࡢᅾᏯ⒪㣴⪅࡬ࡢᒃᏯእ࡟࠾ࡅࡿゼ－ 109 －

ၥ┳ㆤᐇ㊶ࡢ㛵㐃せᅉ ➨ 24 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍Ꮫ⾡㞟఍ 2019.8.24 ᒣᙧ┴❧ಖ೺་⒪኱Ꮫ㸪ᒣᙧ┴ᒣᙧᕷ
11. ᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊ୰ᒣ⋹ዉࠊ㛗ἑࡘࡿࡼࠊᯈᇉࡺࡳࠊすᒣᬡ ᅾᏯேᕤ࿧྾⒪ἲࢆ⥅⥆ࡋ࡚࠸ࡿ➽ࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅ࡢ࿧྾ᶵ⬟࡜ᄟୗ㞀ᐖࡢ㛵ಀ ࿧྾ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࢆ⥅⥆ࡋࡓ㛗ᮇ౛ࡢ᳨ウ ➨ 24 ᅇ᪥ᮏᅾᏯࢣ࢔Ꮫ఍Ꮫ⾡㞟఍ in ௝ྎ 2019.7.28 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸪ᐑᇛ┴௝ྎᕷ12. ཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ࠊᑠ಴ᮁᏊ 㞴⑓ᝈ⪅ࡢᆅᇦᨭ᥼࡟
࠾ࡅࡿከ⫋✀㐃ᦠࡢᵓᡂせ⣲ ➨ 24 ᅇ᪥ᮏᅾᏯࢣ࢔Ꮫ఍Ꮫ⾡㞟఍ in ௝ྎ 2019.7.28 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸪ᐑᇛ┴௝ྎᕷ
13. ᯈᇉࡺࡳࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊᐑཎ⯙ࠊᑠ᳃ဴኵ ⏕άᐇែㄪᰝ
࠿ࡽࡳࡓ⚄⤒➽⑌ᝈ㞴⑓ᝈ⪅ࡢ᪥ᖖ⏕ά≧ἣ࡜἞⒪ࡢ‶㊊ࡢ㛵ಀ ➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2019.5.25 ኱㜰ᅜ㝿఍㆟ሙ࣭࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ኱㜰㸪኱㜰ᗓ኱㜰ᕷ
14. ᯇ⏣༓᫓ࠊΎỈಇኵࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊⓑ⏣༓௦Ꮚࠊ୰ᒣ⋹ዉࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊࠊすᒣᬡࠊ἟ᒣ㈗ஓ ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅࡟࠾ࡅࡿ⯉⫧኱ࡢฟ⌧⋡࡜⮫ᗋⓗ≉ᚩ࡜ࡢ㛵ಀ ➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2019.5.25 ኱㜰ᅜ㝿఍㆟ሙ࣭࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ
኱㜰㸪኱㜰ᗓ኱㜰ᕷ15. ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯘ೺ኴ㑻ࠊΎỈಇኵࠊཎཱྀ㐨Ꮚࠊᮌ⏣⪔ኴࠊᑠ᳃㝯ྖ ALS Ẽ⟶ษ㛤ேᕤ࿧྾⪅࡟࠾ࡅࡿ⮫ᗋ⤒㐣ୖࡢࢣ࢔ᅔ㞴࡜㐠ື⚄⤒௨እ࡬ࡢኚᛶ࡜ࡢ㛵ಀ㸦࣓ࢹ࢕࢝ࣝࢭࢵࢩ࣭ࣙࣥඃ⚽₇㢟㸧 ➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2019.5.25 ኱㜰ᅜ㝿఍㆟ሙ࣭
࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ኱㜰㸪኱㜰ᗓ኱㜰ᕷ
16. ᯘ೺ኴ㑻ࠊ୰⏣Ᏻᾈࠊ୰ᒣඃᏘࠊ㛗ᑿ㞞⿱ࠊ☾ᓮⱥ἞ ALS ࡟࠾ࡅࡿ DATscan ᧜ᙳࡢព⩏➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2019.5.24 ኱㜰ᅜ㝿఍㆟ሙ࣭࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ኱㜰㸪኱㜰ᗓ኱㜰ᕷ
17. ᮌ⏣⪔ኴࠊΎỈಇኵࠊᮌᮧⱥ⣖ࠊ᳃ᓥுࠊୖᒣຮࠊ୰ᒣඃᏘࠊᕝ⏣᫂ᗈࠊ☾ᓮⱥ἞
Relationship between EMG-detected fasciculation potentials and US-detected fasciculations in ALS➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2019.5.24 ኱㜰ᅜ㝿఍㆟ሙ࣭࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ኱㜰㸪኱㜰ᗓ኱㜰ᕷ
18. ΎỈಇኵࠊᮌᮧⱥ⣖ࠊ᳃ᓥுࠊΎỈᑦᏊࠊᑠ㔝ᓮ㤶ⱑࠊ᪂஭⋢༡ࠊᕤ⸨ⱆ⾰Ꮚࠊ➟ཎⰋ㞝ࠊᮏ㛫Ṋⶶࠊཎ⏣᫂ᏊࠊᯘගᏊࠊᒣཱྀᣙேࠊ㜰ཱྀඃ⌮ࠊ୰ᒣඃᏘࠊ☾ᓮⱥ἞ ⚄⤒㞴⑓ࢆᑐ㇟࡜ࡋࡓ⦆࿴ࢣ࢔ࢳ࣮࣒㸦PCT㸧ࡢάື࡜ࡑࡢᡂᯝࡢሗ࿌ ➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱
఍ 2019.5.23 ኱㜰ᅜ㝿఍㆟ሙ࣭࣮ࣜ࢞ࣟ࢖ࣖࣝ࣍ࢸࣝ኱㜰㸪኱㜰ᗓ኱㜰ᕷ
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 53 ௳ 㸧
1.

ᯇ⏣༓᫓ ༡ከᦶಖ೺ᡤ㞴⑓ᝈ⪅ᅾᏯ⒪㣴ᨭ᥼ィ⏬⟇ᐃ࣭ホ౯ጤဨ఍ 2020.3.11 ᮾி㒔ከᦶᕷ2.

ᑠ಴ᮁᏊ ᅾᏯ㞴⑓ᝈ⪅ᆅᇦᨭ᥼ᑐ⟇᥎㐍஦ᴗ࡟ᇶ࡙ࡃゼၥ┦ㄯဨ⫱ᡂ஦ᴗ࡟ᇶ࡙ࡃ◊ಟ఍ࠕᨭ᥼⪅࡜ඹ࡟⪃࠼ࡿ㞴⑓➼ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ࡢഛ࠼࡜⅏ᐖ᫬ಶูᨭ᥼
ィ⏬ࠖㅮᖌ 2020.2.21 ༓ⴥ┴ᕷᕝಖ೺ᡤ㸪༓ⴥ┴ᕷᕝᕷ

3.

ᑠ಴ᮁᏊ 㞴⑓ࡢಖ೺ᖌ◊ಟ 2020.1.30 ቚ⏣༊ᙺᡤ㸪ᮾி㒔ቚ⏣༊

4.

ᑠ಴ᮁᏊ ᖹ᫬࠿ࡽ⪃࠼ࡿ㞴⑓ᅾᏯேᕤ࿧྾ჾ౑⏝⪅➼ࡢ⅏ᐖ᫬ࡢഛ࠼㹼ᝈ⪅࣭ᐙ᪘ࢆྵ
ࡴᨭ᥼యไᵓ⠏ࡢࡓࡵ࡟㹼㸦ㅮ₇㸧ㅮᖌ 㞴⑓┦ㄯᨭ᥼⪅ᨭ᥼◊ಟ఍ 2020.1.24 ᮅ㟘ಖ－ 110 －

೺ᡤ㸪ᇸ⋢┴ᮅ㟘ᕷ
5.

ᯇ⏣༓᫓ ቚ⏣༊ᅾᏯேᕤ࿧྾ჾ౑⏝⪅⅏ᐖ᫬ᨭ᥼◊ಟ 2020.1.21 ᮾி㒔ቚ⏣༊

6.

୰ᒣඃᏘ*ࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊ 㞴⑓࡟࠾ࡅࡿ┳ㆤᖌࡢᙺ๭㹼ᅾᏯ⒪㣴ᨭ᥼ࠊ≉࡟ேᕤ࿧྾ჾ౑⏝⪅࡬ࡢゼၥ┳ㆤᥦ౪ࡢどⅬ࠿ࡽ㹼 ཌ⏕ປാ┬㞴἞ᛶ⑌ᝈඞ᭹ᨻ⟇◊✲࣭㞴⑓ᝈ⪅࡬ࡢ⥲ྜⓗᨭ᥼యไ࡟㛵ࡍࡿ◊✲⌜఍㆟ 2020.1.18 JA ඹ῭ࣅࣝ࢝ࣥࣇ࢓ࣞࣥࢫ࣮࣍ࣝ㸪ᮾி㒔༓௦⏣༊

7.

ཎཱྀ㐨Ꮚ ⚄⤒㞴⑓⪅࡜ᐙ᪘ࢆ୰ᚰ࡜ࡋࡓ⒪㣴⏕άᨭ᥼ 㟼ᒸ┴❧኱Ꮫ┳ㆤᏛ㒊ᆅᇦᐙ᪘ᨭ᥼ㄽ≉ูㅮ⩏ 2020.1.14 㟼ᒸ┴㟼ᒸᕷ

8.

ཎཱྀ㐨Ꮚ ᮾி㒔❧⚄⤒⑓㝔┳ㆤ◊✲ࠕࢡࣜࢸ࢕࣮ࢡࠖㅮᖌ 2020.1.7 ᮾி㒔❧⚄⤒⑓㝔㸪ᮾி㒔ᗓ୰ᕷ

9.

ᯇ⏣༓᫓ ᮾி㒔㞴⑓ᑐ⟇஦ᴗ࣭㞴⑓ࢭ࣑ࢼ࣮බ㛤ㅮᗙࠕேᕤ࿧྾ჾࡢ⅏ᐖᑐ⟇࡟ࡘ࠸࡚ࠖ
2019.12.20 ᮾி㒔᪂ᐟ༊

10. ᑠ ಴ ᮁ Ꮚ  ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ⿦ ╔ ᝈ ⪅ ࡢ ⅏ ᐖ ᫬ ࡢ ഛ ࠼ ࡢ ᥎ 㐍 ࡟ ࠿ ࠿ ࡿ ◊ ಟ  ㅮ ᖌ
2019.12.19 ᮾி㒔ᩥி༊
11. ཎཱྀ㐨Ꮚ ᅾᏯ⒪㣴ᨭ᥼ィ⏬⟇ᐃ࣭ホ౯ጤဨ఍ ᆅᇦ㛵ಀ⪅఍㆟ࠕ࢖ࣥࢩࢹࣥࢺ࣭࢔ࢡࢩ
ࢹࣥࢺࠖ 2019.12.16 ᮾி㒔ᓥࡋࡻಖ೺ᡤ኱ᓥฟᙇᡤ㸪ᮾி㒔኱ᓥ12. ୰ᒣඃᏘ ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ㹼㞴⑓ࢣ࢔ࠊ௓ㆤ⫋࡟ồࡵࡽࢀ࡚࠸ࡿࡇ࡜㹼 ࢔ࣉࣞ௓ㆤ
஦ᴗᡤ◊ಟ 2019.12.6 Ṋⶶ㔝ࣉࣞ࢖ࢫ㸪ᮾி㒔Ṋⶶ㔝ᕷ
13. ཎཱྀ㐨Ꮚ ᮾி㒔❧⚄⤒⑓㝔┳ㆤ◊✲ࠕ㉁ⓗ◊✲ࠖㅮᖌ 2019.12.6 ᮾி㒔❧⚄⤒⑓㝔㸪ᮾி㒔ᗓ୰ᕷ
14. ᯇ⏣༓᫓ ௒ᚋࡢ⅏ᐖ࡟ഛ࠼࡚͐㹼⅏ᐖಶูᨭ᥼ィ⏬ࡢ⟇ᐃ࡟ࡘ࠸࡚㹼 ໭ከᦶす㒊ಖ೺་⒪ᅪ㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ 2019.12.5 ᮾி㒔❧ᕝᕷ
15. ཎཱྀ㐨Ꮚ ᅾᏯ㞴⑓ᝈ⪅་⒪ᶵჾ㈚୚஦ᴗ ゼၥ┳ㆤᖌ࢝ࣥࣇ࢓ࣞࣥࢫࠕ࢖ࣥࢩࢹࣥࢺ࣭
࢔ࢡࢩࢹࣥࢺ࡟ࡘ࠸࡚ࠖ 2019.11.25 ᮾி㒔ከᦶ❧ᕝಖ೺ᡤ㸪ᮾி㒔❧ᕝᕷ
16. ཎཱྀ㐨Ꮚ Ụᮾ༊㛗ᑑࢧ࣏࣮ࢺࢭࣥࢱ࣮㸦ᆅᇦໟᣓᨭ᥼ࢭࣥࢱ࣮㸧⫋ဨ㈨㉁ྥୖ◊ಟ ㅮ
ᖌ 2019.11.19 ᮾி㒔Ụᮾ༊
17. ᯇ⏣༓᫓ ゼၥ┳ㆤ࡛ᚲせ࡞㞴⑓ᝈ⪅ࡢ▱㆑࡜ࢣ࢔ ໭༊ゼၥ┳ㆤࢫࢸ࣮ࢩࣙࣥ㐃⤡༠㆟఍◊ಟ఍ 2019.11.13 ᮾி㒔໭༊18. ཎཱྀ㐨Ꮚ ୕㮚ᕷᆅᇦࢣ࢔఍㆟ࠕ㞴⑓ࡢከ⫋✀㐃ᦠղࠖㅮ⩏ 2019.11.11 ᮾி㒔୕㮚ᕷ
19. ୰ᒣඃᏘ 㞴⑓ᝈ⪅ࡢ⌮ゎ࡜ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ ᖹᡂ 30 ᖺᗘᒣ᲍┴ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐
ࢿ࣮ࢪ࣮ࣕ㣴ᡂ◊ಟ఍ 2019.11.5 ᒣ᲍┴⏥ᗓᕷ
20. ཎཱྀ㐨Ꮚ 㞴⑓ᝈ⪅ࡢ⌮ゎ࡜ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ ᖹᡂ 30 ᖺᗘᒣ᲍┴ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐
ࢿ࣮ࢪ࣮ࣕ㣴ᡂ◊ಟ఍ 2019.11.5 ᒣ᲍┴⏥ᗓᕷ21. ୰ᒣඃᏘ ࠙┳ㆤᐇ㊶ղࠚ4㸬⏕άሙ㠃࣭≧ἣูᨭ᥼ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ 2019.11.3 ᮾி㒔኱⏣༊
22. ୰ᒣඃᏘ ࠙┳ㆤᐇ㊶ࠚ₇⩦ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ
2019.11.2 ᮾி㒔኱⏣༊
23. ཎཱྀ㐨Ꮚ ᇶ♏⛉┠㞴⑓ไᗘࡢ⌧≧ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ 2019.11.2 ᮾி㒔኱⏣༊
24. ᯇ⏣༓᫓ ࠙┳ㆤᐇ㊶ࠚ₇⩦ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ
2019.11.2 ᮾி㒔኱⏣༊

－ 111 －

25. ᑠ಴ᮁᏊ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ಶูᨭ᥼ィ⏬సᡂ࣭ᨭ᥼యไᩚഛ࡟࠾ࡅࡿ␃ព
Ⅼ 㸫㏆ᖺࡢ⅏ᐖࠊ௚⮬἞య࡛ࡢ࡜ࡾࡃࡳ࠿ࡽࡢᏛࡧ㸫㸦㞴⑓ࡢಖ೺ᖌ◊ಟ㸧 2019.10.28
ᮾி㒔୰㔝༊
26. ୰ᒣඃᏘ ⚄⤒㞴⑓⒪㣴⪅࡟࠾ࡅࡿẼ㐨ࢣ࢔࡜ᅾᏯ⏝་⒪ᶵჾࡢᏳ඲⟶⌮ ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟᛂ⏝ࢥ࣮ࢫ 2019.10.18 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
27. ୰ᒣඃᏘ 㞴⑓┳ㆤ࣭ᖇி⛉Ꮫ኱Ꮫㅮ⩏ 2019.10.11 ᖇி⛉Ꮫ኱Ꮫ㸪ᮾி㒔㊊❧༊28. ᯇ ⏣ ༓ ᫓  ゼ ၥ ┳ ㆤ ᖌ ࢆ ᑐ ㇟ ࡜ ࡋ ࡓ ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ⒪ 㣴 ⪅ ࡢ ┳ ㆤ ࡟ 㛵 ࡍ ࡿ ◊ ಟ
2019.10.8 බ┈㈈ᅋἲேᮾி㒔┳ㆤ༠఍ᮾி㒔ࢼ࣮ࢫࣉࣛࢨ㸪ᮾி㒔᪂ᐟ༊
29. ᯇ⏣༓᫓ ALS࣭ࣃ࣮࢟ࣥࢯࣥ⑓ᝈ⪅ࡢ┳ㆤ 2019.10.8 බ┈㈈ᅋἲேᮾி㒔┳ㆤ༠఍ᮾி㒔ࢼ࣮ࢫࣉࣛࢨ㸪ᮾி㒔᪂ᐟ༊
30. ཎཱྀ㐨Ꮚ ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟࠕ㞴⑓┳ㆤ஦౛᳨ウ ⚄⤒㞴⑓ゼၥ┳ㆤࡢ┳ㆤ㐣⛬ࠖㅮᖌ 2019.10.7 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
31. ᑠ಴ᮁᏊ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ࡢᨭ᥼࡟ࡘ࠸࡚ ㏆ᖺࡢ⅏ᐖ⤒㦂➼࠿ࡽࡢᥦ᱌࡜ㄢ㢟࡬ࡢྲྀ⤌⤂௓◊ಟ㸦ㅮ₇㸧ㅮᖌ 2019.10.2 ᮾி㒔⦎㤿༊
32. ୰ᒣඃᏘ ேᕤ࿧྾⒪㣴⪅ࡢ⤊ᮎᮇ࡟ࡘ࠸࡚ࡢᏛ⩦఍ ゼၥ┳ㆤࢫࢸ࣮ࢩࣙࣥⰱⰼ
2019.9 ᮾி㒔ୡ⏣㇂༊
33. ᯇ⏣༓᫓ ALS ࡜ඹ࡟⚾ࡽࡋࡃ⏕ࡁࡿ㸟㹼ᑓ㛛་ࡢヰ࡜ࡈᮏே࣭ᐙ᪘ࡢ㞟࠸㹼 ከᦶᗓ୰ಖ೺ᡤ 2019.9.26 ᮾி㒔ᑠᖹᕷ
34. ୰ᒣඃᏘ ⅏ᐖ᫬ಶูᨭ᥼ィ⏬ᐇ㊶⦅ ᗓ୰ಖ೺ᡤᏛ⩦఍ 2019.9.24 ᮾி㒔ᗓ୰ᕷ
35. ᑠ಴ᮁᏊ 㞴⑓ಖ೺ᖌάືࡢᴫせ࡜ᨭ᥼ࡢ࣏࢖ࣥࢺ ㅮᖌ 2019.9.18 ᮡ୪༊ಖ೺ᡤ㸪ᮾி㒔ᮡ୪༊
36. ᑠ಴ᮁᏊ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ಶูᨭ᥼ィ⏬ ㏆ᖺࡢ⅏ᐖ⤒㦂➼࠿ࡽࡢᥦ᱌
࡜ㄢ㢟࡬ࡢྲྀ⤌⤂௓㸦ㅮ₇㸧ㅮᖌ 2019.9.4 ᮾி㒔Ụᡞᕝ༊37. ᯇ⏣༓᫓ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ಶูᨭ᥼ィ⏬⟇ᐃ ከᦶ❧ᕝಖ೺ᡤ 2019.9.3
ᮾி㒔❧ᕝᕷ
38. ᑠ಴ᮁᏊ 㞴⑓ಖ೺ᖌάືࡢᴫせ࡜ᨭ᥼ࡢ࣏࢖ࣥࢺ ㅮᖌ 2019.9.2 ⚄ዉᕝ┴ᶓ὾ᕷ39. ୰ᒣඃᏘ ⚄⤒࣭➽㞴⑓⒪㣴⪅࡬ࡢ࿧྾ࢣ࢔ ࣂࢵࢡࣂࣝࣈ࣐ࢫࢡ࡟ࡼࡿ⫵ᐜ㔞ࣜࢡ࣮ࣝࢺ࣓ࣥࢺ㸦LVR㸧࡜࿧྾ࢣ࢔ ᪥ᮏ㞴⑓┳ㆤᏛ఍ࣉࣞࢭ࣑ࢼ࣮ 2019.8.22 ᒣᙧ┴ಖ೺་⒪኱Ꮫ㸪ᒣᙧ┴ᒣᙧᕷ40. ཎཱྀ㐨Ꮚ ᮾி㒔௓ㆤᨭ᥼ᑓ㛛ဨ◊✲༠㆟఍ ➨ 1 ᅇ኱つᶍ◊ಟࠕ㞴⑓ࡢ▱㆑࡜⌮ゎࢆ῝ࡵࠊᆅᇦ࡛⏕άࡋ࡚࠸ࡃࡓࡵ࡟ᚲ⏝࡞㐃ᦠ࡜ࢣ࢔࣐ࢿࢪ࣓ࣥࢺࡢどⅬ࡟ࡘ࠸࡚Ꮫࡪࠖㅮᖌ
2019.8.6 ࡞࠿ࡢ ZERO ᑠ࣮࣍ࣝ㸪ᮾி㒔୰㔝༊
41. ᑠ ಴ ᮁ Ꮚ  ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ⿦ ╔ ᝈ ⪅ ࡢ ⅏ ᐖ ᫬ ࡢ ഛ ࠼ ࡢ ᥎ 㐍 ࡟ ࠿ ࠿ ࡿ ◊ ಟ  ㅮ ᖌ
2019.7.31. ᮾி㒔ୡ⏣㇂༊
42. ཎཱྀ㐨Ꮚ ୕㮚ᕷᆅᇦࢣ࢔఍㆟ࠕ㞴⑓ࡢከ⫋✀㐃ᦠձࠖㅮ⩏ 2019.7.8 ᮾி㒔୕㮚ᕷ
43. ᯇ⏣༓᫓ ᅾᏯேᕤ࿧྾ჾࡢ⌮ゎ㹼సືཎ⌮ࡢ⌮ゎ࡜㟁※⟶⌮ࡢᇶ♏▱㆑㹼 ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟ㸦ᗙᏛ◊ಟϨ㸧 2019.6.20 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
44. ᯇ ⏣ ༓ ᫓  ゼ ၥ ┳ ㆤ ᖌ ࢆ ᑐ ㇟ ࡜ ࡋ ࡓ ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ⒪ 㣴 ⪅ ࡢ ┳ ㆤ ࡟ 㛵 ࡍ ࡿ ◊ ಟ
2019.6.18 බ┈㈈ᅋἲேᮾி㒔┳ㆤ༠఍ᮾி㒔ࢼ࣮ࢫࣉࣛࢨ㸪ᮾி㒔᪂ᐟ༊
45. ୰ᒣඃᏘ ࢺ࣮ࢡࢭࢵࢩࣙࣥࠕቃࢆ㉺࠼ࡓ▐㛫ࠖ ቃࢆ㉺࠼࡚タ❧グᛕ 2019.6.15 ᮾி࣑ࢵࢻࢱ࢘ࣥࢱ࣮࣡4 㝵 Room7㸪ᮾி㒔 ༊－ 112 －

46. ୰ᒣඃᏘ ⚄⤒㞴⑓⒪㣴⪅ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥᨭ᥼ 2019 ᖺᗘᅾᏯேᕤ࿧྾ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟ࣭ᇶ♏ࢥ࣮ࢫㅮ⩏ 2019.6.12 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
47. ཎཱྀ㐨Ꮚ ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟࠕ㞴⑓ᆅᇦᨭ᥼ࢳ࣮࣒࡛ࡲࡶࡿᅾᏯ⒪㣴Ᏻ඲ࠖㅮᖌ 2019.6.12 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊48. ୰ᒣඃᏘ ኟࡢࢭ࣑ࢼ࣮ 2019.6.11 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
49. ᑠ಴ᮁᏊ 㞴⑓ࡢಖ೺ᖌ◊ಟࠕ㞴⑓ἲ᪋⾜ᚋࡢಖ೺άືࡢయไ࣭㞴⑓ᑐ⟇ᆅᇦ༠㆟఍➼ࡢ≧ἣㄪᰝ࠿ࡽࠖ ኟࡢࢭ࣑ࢼ࣮㞴⑓ࡢᆅᇦࢣ࢔ࢥ࣮ࢫ 2019.6.11 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸪ᮾி㒔ୡ⏣㇂༊
50. ୰ᒣඃᏘ ᅾᏯேᕤ࿧྾⒪ἲ┳ㆤᏛ₇⩦ࠕᅾᏯேᕤ࿧྾࡜ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࠖ ᮾி་⛉ṑ⛉኱ᏛᏛ㒊ㅮ⩏ 2019.6.7 ᮾி་⛉ṑ⛉኱Ꮫ㸪ᮾி㒔ᩥி༊
51. ᯇ⏣༓᫓ ᅜ❧⑓㝔ᶵᵓ⟽᰿⑓㝔࣭᪂᥇⏝┳ㆤᖌ࡟ᑐࡍࡿࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡟㛵ࡍࡿ◊
ಟ 2019.5.28 ⚄ዉᕝ┴ᑠ⏣ཎᕷ
52. ୰ᒣඃᏘ ⅏ᐖ᫬ᨭ᥼࡟ࡘ࠸࡚ 2019.5.17 ᑠᖹಖ೺ᡤ㸪ᮾி㒔ᑠᖹᕷ53. ᑠ಴ᮁᏊ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⅏ᐖ᫬ࡢഛ࠼࡜ಶูᨭ᥼ィ⏬㸦ㅮ₇㸧ㅮᖌ ᕝ㉺ᕷᆅᇦ㞴⑓ᚑ஦⪅◊ಟ఍ 2019.5.16 ᕝ㉺ᕷಖ೺ᡤ㸪ᇸ⋢┴ᕝ㉺ᕷIV. ≉グ஦㡯1.

୰ᒣඃᏘ ➨ 60 ᅇ᪥ᮏ⚄⤒Ꮫ఍⥲఍࣓ࢹ࢕࢝ࣝࢭࢵࢩࣙࣥඃ⚽₇㢟 2019.5.25

2.

ᯇ⏣༓᫓ ᮾி㒔ᅾᏯேᕤ࿧྾ჾ౑⏝⪅⅏ᐖ᫬ᨭ᥼ᣦ㔪ᨵᐃసᴗ࣭࣮࣡࢟ࣥࢢࢢ࣮ࣝࣉ

－ 113 －

ࣉࣟࢪ࢙ࢡࢺྡ

⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 10 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Takaku S, *Sango K. Zonisamide enhances neurite outgrowth from adult rat dorsal root ganglion
neurons, but not proliferation or migration of Schwann cells. Histochem Cell Biol 153:177-184(2020)

2.

Akamine T, Takaku S, Suzuki M, Niimi N, Yako H, Matoba K, Kawanami D, Utsunomiya K,
Nishimura R, *Sango K. Glycolaldehyde induces sensory neuron death through activation of the cJun N-terminal kinase and p-38 MAP kinase pathways. Histochem Cell Biol 153:111-119 (2020)

3.

Makino E, Nakamura N, Miyabe M, Ito M, Kanada S, Hata M, Saiki T, Sango K, Kamiya H,
Nakamura J, Miyazawa K, Goto S, Matsubara T, *Naruse K. Conditioned media from dental pulp
stem cells improved diabetic polyneuropathy via anti-inflammatory, neuroprotective andangiogenic actions: cell-free regenerative medicine for diabetic polyneuropathy. J Diabetes
Investig 10:1199-1208 (2019)4.

Kato A, Tatsumi Y, Yako H, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakmura J,*Kato K. Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative
stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells. Neurosci
Res 147:26-32 (2019)5.

Tatsumi Y, Kato A, Mano M, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakamura J,*Kato K. Omega-3 polyunsaturated fatty acids exert antioxidant effects through the Nrf2 pathway
in the immortalized mouse Schwann IMS32 Cells. J Diabetes Investig 10:602-612 (2019)6.

Lee JS, Kanai K, Suzuki M, Kim WS, Yoo HS, Fu Y, Kim DK, Jung BC, Choi M, Oh KW, Li Y,
Nakatani M, Nakazato T, Sekimoto S, Funayama M, Yoshino H, Kubo SI, Nishioka K, Sakai R,
Ueyama M, Mochizuki H, Lee HJ, Sardi SP, Halliday GM, Nagai Y, Lee PH, Hattori N, *Lee SJ.
$U\OVXOIDWDVH$DJHQHWLFPRGLILHURI3DUNLQVRQ VGLVHDVHLVDQĮ-synuclein chaperone. Brain
142:2845-2859 (2019)7.

Sakai R, Suzuki M, Ueyama M, Takeuchi T, Minakawa EN, Hayakawa H, Baba K, Mochizuki H,
1DJDL<(.PXWDQWĮ-synuclein is more degradation resistant and exhibits greater toxic effects thanwild-W\SHĮ-synuclein in Drosophila models of Parkinson's disease. PLoS One 14:e0218261 (2019)8.

Tatsumi Y, Matsumoto N, Iibe N, Watanabe N, Torii T, Sango K, Homma K, Miyamoto Y,
Sakaguchi H, *Yamauchi J. CMT type 2N disease-associated AARS mutant inhibits neurite
outgrowth that can be reversed by valproic acid. Neurosci Res 139:69-78 (2019)9.

Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S,
Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki
M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y,
Antebi A, *Yoshimori T. Suppression of autophagic activity by Rubicon is a signature of aging.
Nat Commun 10:847 (2019) [#equal contribution]－ 114 －

10. *Tanaka S, Honda Y, Takaku S, Koike T, Oe S, Hirahara Y, Yoshida T, Takizawa N, Takamori Y,
Kurokawa K, Kodama T, Yamada H. Involvement of PLAGL1/ZAC1 in hypocretin/orexintranscription. Int J Mol Med 43:2164-2176 (2019)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 8 ௳㸧
1.

Ikenaka K, Suzuki M, Mochizuki H, *Nagai Y. Lipids as Trans-$FWLQJ(IIHFWRUVIRUĮ-Synucleinin the Pathogenesis of Parkinson's Disease. Front Neurosci 13:693 (2019) 㸦ᰝㄞ࠶ࡾ㸧

2.

*ඵᏊⱥྖࠊ୕஬୍᠇ ࣓ࢱ࣮࣒࣎ࣟ࡜ࣇࣛࢵࢡࢫ࢔ࢼࣛ࢖ࢨ࣮ࢆ⏝࠸ࡓࢩࣗ࣡ࣥ⣽⬊ᰴ
IMS32 ࡢ⢾௦ㅰኚືゎᯒ Peripheral Nerve 30:186-188 (2019)3.

*୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓ែ⏕≀Ꮫʊ⣽⬊࠿ࡽಶయ࡬ʊ ⢾ᒀ⑓ྜే⑕ 33:237-240 (2019)4.

Niimi N, Takaku S, Yako H, *Sango K. Chapter 23: Drug-induced demyelinating neuropathies, In:
Myelin-Basic and Clinical Advances, Advances in Experimental Medicine and Biology 1190
(Eds: Sango K, Ogata T, Susuki K, Yamauchi J), Springer Singapore, pp.357-369 (2019)(ISBN:978-981-32-9635-0) 㸦ᰝㄞ࠶ࡾ㸧

5.

*Sango K, *Ogata T, *Susuki K, *Yamauchi J (Eds). Myelin-Basic and Clinical Advances,
Advances in Experimental Medicine and Biology 1190, Springer Singapore, pp. 1-378.
(ISBN:978-981-32-9635-0; eBook ISBN:978-981-329-636-7) 㸦ᰝㄞ࠶ࡾ㸧

6.

Niimi N, Yako H, Takaku S, *Sango K. Chapter 2: Pathogenetic mechanisms of amiodaroneinduced peripheral neuropathy. In: Advances in Medicine and Biology, Vol.136 (Ed:Berhardt
LV), Nova Science Publishers, Inc, Hauppauge, USA, pp.41-62 (ISBN:978-1-53614-722-3)
㸦ᰝㄞ࠶ࡾ㸧

7.

*୕஬୍᠇㸦௻⏬⦅㞟㸧᭶ห⢾ᒀ⑓➨➨ 124 ᕳࠕ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓⑓ែゎ᫂࡜἞⒪ᡓ

␎ࠖ, ་Ꮫฟ∧, ༳ๅ୰.
8.

*୕஬୍᠇ࠊ᪂ぢ┤Ꮚ ࠊඵᏊⱥྖ ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓ែ ⢾ᒀ⑓἞⒪ࡢࢽ࣮ࣗࣃࣛࢲ࢖࣒ ➨ 4 ᕳࠕ⢾ᒀ⑓࡟ྜేࡍࡿ⑓ែ࡜ࡑࡢ἞⒪ࠖ㸦ຍ᮶ᾈᖹ⦅㸧 ་⸆ࢪ࣮ࣕࢼࣝ♫ 169176 (2019)II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 4 ௳㸧
1.

୕஬୍᠇ ᡂᅉ࡟ᇶ࡙࠸ࡓ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ἞⒪ᡓ␎ ➨ 34 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍
ᩍ⫱ㅮ₇ 2019.9.27 ኱㜰ᅜ㝿఍㆟ሙ㸪኱㜰ᗓ኱㜰ᕷ

2.

Sango K, Takaku S, Niimi N, Yako H.  Exendin-4 promotes neurite outgrowth, neuronalsurvival and myelination via activating PI3 kinase signaling pathway in vitro. Neurodiab2019 
2019.9.14 Sitges/Barcelona, Spain3.

୕ ஬ ୍ ᠇  ⢾ ᒀ ⑓ᛶ ࢽࣗ ࣮ ࣟ ࣃ ࢳ ࣮ ࡢ ศᏊ ⑓ែ  ➨ 60 ᅇ ᪥ ᮏ⚄ ⤒Ꮫ ఍ Ꮫ ⾡ ኱ ఍
2019.5.23 ኱㜰ᅜ㝿఍㆟ሙ㸪኱㜰ᗓ኱㜰ᕷ

4.

୕஬୍᠇ ࡶࡗ࡜ὀ┠ࡋ࡚࡯ࡋ࠸⢾ᒀ⑓ᛶࢽ࣮ࣗࣟࣃࢳ࣮ ୰㔝༊ෆ⛉་఍Ꮫ⾡ㅮ₇఍
2019.7.9 ୰㔝༊་ᖌ఍㤋㸪ᮾி㒔୰㔝༊

－ 115 －

ࡑࡢ௚ 㸦ィ 25 ௳㸧⮬⏤ᥖ㍕
1.

Sango K, Yako H, Niimi N, Takaku S. Pathogenic factors of diabetic neuropathy: how pancreaticß cell dysfunction affects peripheral nervous system? ➨ 97 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍ 2020.3.18 ኱ศ┴ูᗓᕷ㸦㞟఍୰Ṇ࣭ㄅୖ㛤ദ㸧

2.

Sango K, Takaku S, Niimi N, Yako H. Exendin-4 promotes neurite outgrowth, Schwann cell
survival/migration and myelination in vitro.  ➨ 97 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍ 2020.3.18 ኱ศ┴ูᗓᕷ㸦㞟఍୰Ṇ࣭ㄅୖ㛤ദ㸧

3.

ඵᏊⱥྖࠊ᪂ぢ┤Ꮚ ࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶 ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉ
ᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿ IMS32 ࢩࣗ࣡ࣥ⣽⬊ࡢ⢾௦ㅰゎᯒ ➨ 5 ᅇ࣑࢚ࣜࣥ◊✲఍ 2020.2.22 ⚄ዉᕝ┴ᶓ὾ᕷ

4.

㕥ᮌ࣐ࣜࠊAnne-Marie Neumannࠊᩧ⸨ຬ஧ࠊ⸨᥃ఙᏹࠊ࿴⏣ᆂྖࠊ୕஬୍᠇ࠊỌ஭⩏㝯㣗㣵ไ㝈ࡀ⚄⤒ኚᛶ⑌ᝈࣔࢹࣝࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ⚄⤒ኚᛶࢆᨵၿࡍࡿศᏊ࣓࢝ࢽࢬ࣒
ࡢゎ᫂ ➨ 34 ᅇ᪥ᮏ⢾ᒀ⑓࣭⫧‶ື≀Ꮫ఍ᖺḟᏛ⾡㞟఍ 2020. 2.1 ⩌㤿┴㧗ᓮᕷ

5.

Sango K, Takaku S, Niimi N, Yako H. Exendin-4 promotes neurite outgrowth, Schwann cell
migration and myelination in vitro. ➨ 24 ᅇࢢࣜ࢔◊✲఍ 2019.11.30 ᮾி㒔6.

኱ሙᰟᶞ ࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࢩࣙ࢘
ࢪࣙ࢘ࣂ࢚ࡢ⚄⤒⑕≧ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไᅉᏊ Rubicon ࡢⓎ⌧ᢚไ࡟ࡼࡾᨵၿࡍࡿ
㤳㒔኱Ꮫᮾிࣂ࢖࢜ࢥࣥࣇ࢓ࣞࣥࢫ 2019 2019.11.15 ᮾி㒔

7.

Suzuki M, Neumann A-M, Saitoh Y, Fujikake N, Wada K, K. Sango K, Nagai Y. Dietary yeast
restriction attenuates polyglutamine toxicity via insulin-like signaling and immune signaling in
Drosophila. 49th Annual Meeting of Society for Neuroscience 2019.10.23 Chicago, CA, USA

8.

Oba M, Nagai Y, Fukui K, Sango K, Suzuki M. Knockdown of Rubicon, a negative regulator of
autophagy, suppresses polyglutamine-induced toxicity in Drosophila. 49th Annual Meeting ofSociety for Neuroscience 2019.10.23 Chicago, CA, USA

9.

㉥ᕊ཭௦ ࠊ㧗ஂ㟼㤶 ࠊ㕥ᮌ࣐ࣜࠊ᪂ぢ┤Ꮚ ࠊඵᏊⱥྖࠊⓗሙᆂ୍㑻ࠊᏱ㒔ᐑ୍඾ࠊ୕
஬୍᠇ ࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄࢻ࡟ࡼࡿࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊Ṛㄏᑟࡢᶵᵓゎ᫂ ➨34 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ 2019.9.27 ኱㜰ᅜ㝿఍㆟ሙ㸪኱㜰ᗓ኱㜰ᕷ

10. ඵᏊⱥྖࠊ᪂ぢ┤Ꮚ ࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶 ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉ
ᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿࢩࣗ࣡ࣥ⣽⬊Ṛ࡟ࡣ, PARP ࡢάᛶ໬ࡀ㛵୚ࡍࡿ  ➨34 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ 2019.9.27 ኱㜰ᅜ㝿఍㆟ሙ㸪኱㜰ᗓ኱㜰ᕷ
11. 㧗ஂ㟼㤶 ࠊ୕஬୍᠇ ࢰࢽࢧ࣑ࢻࡣᡂ⇍ࣛࢵࢺᚋ᰿⚄⤒⠇ࢽ࣮ࣗࣟࣥ࡟┤᥋స⏝ࡋ, ⚄⤒✺㉳ఙ㛗ࢆಁ㐍ࡍࡿ ➨ 92 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2019.9.20 ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ
12. 㧗ஂ㟼㤶 ࠊ୕஬୍᠇ GLP-1 ཷᐜయసື⸆ࡢᮎᲈ⚄⤒ಖㆤస⏝㸸⢾ᒀ⑓ᛶ⚄⤒㞀ᐖ࡟ᑐࡍࡿ᭷⏝ᛶࡢ᳨ド ➨ 63 ᅇ᪥ᮏ⸆Ꮫ఍㛵ᮾᨭ㒊 2019.9.14 ໭㔛኱Ꮫ⸆Ꮫ㒊ⓑ㔠࢟ࣕࣥࣃࢫ㸪ᮾி㒔 ༊
13. ㉥ᕊ཭௦ ࠊ㧗ஂ㟼㤶 ࠊ㕥ᮌ࣐ࣜࠊ᪂ぢ┤Ꮚ ࠊඵᏊⱥྖࠊⓗሙᆂ୍㑻ࠊᕝᾉ኱἞ࠊᏱ㒔ᐑ୍඾ࠊすᮧ⌮᫂ࠊ୕஬୍᠇ ࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄࢻ࡟ࡼࡿࢽ࣮ࣗࣟࣥṚㄏᑟࡢᶵᵓゎ᫂௧࿴ඖᖺᗘ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍Ꮫ⾡ㅮ₇఍ 2019.8.31 ᮾி㒔

－ 116 －

14. ඵᏊⱥྖࠊ᪂ぢ┤Ꮚ ࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶 ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉ
ᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿࢩࣗ࣡ࣥ⣽⬊Ṛㄏᑟࡢ࣓࢝ࢽࢬ࣒㸸PARP ࡜ GAPDH ࡢ㛵୚ ௧࿴ඖᖺᗘ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍Ꮫ⾡ㅮ₇఍ 2019.8.31 ᮾி㒔
15. ඵᏊⱥྖࠊ୕஬୍᠇ ࣓ࢱ࣮࣒࣎ࣟ࡜ࣇࣛࢵࢡࢫ࢔ࢼࣛ࢖ࢨ࣮ࢆ⏝࠸ࡓࢩࣗ࣡ࣥ⣽⬊ᰴ
IMS32 ࡢ⢾௦ㅰኚືゎᯒ ➨ 30 ᅇ᪥ᮏᮎᲈ⚄⤒Ꮫ఍Ꮫ⾡㞟఍ 2019.8.24 㔠ἑᕷᩥ໬࣍
࣮ࣝ㸪▼ᕝ┴㔠ἑᕷ
16. *୕஬୍᠇ࠊ㧗ஂ㟼㤶  ᚋ᰿⚄⤒⠇ࢽ࣮ࣗࣟࣥཬࡧࢩࣗ࣡ࣥ⣽⬊࡟ᑐࡍࡿࢰࢽࢧ࣑ࢻࡢಖ
ㆤస⏝ࡢ᳨ウ ➨ 30 ᅇ᪥ᮏᮎᲈ⚄⤒Ꮫ఍Ꮫ⾡㞟఍ 2019.8.23 㔠ἑᕷᩥ໬࣮࣍ࣝ㸪▼ᕝ┴㔠ἑᕷ
17. ඵᏊⱥྖࠊ᪂ぢ┤Ꮚ ࠊຍ⸨ᩥᏊࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇ 㧗ࢢࣝࢥ࣮ࢫ࣭ࣆࣝࣅࣥ㓟Ḟஈ㈇Ⲵ࡛ㄏᑟࡉࢀࡿ⣽⬊Ṛ࡟ᑐࡍࡿࣅࢱ࣑ࣥ B1 ㄏᑟయ࣋ࣥࣇ࢛ࢳ࢔࣑ࣥࡢຠᯝ ➨ 29 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ 2019.8.4 ㏆␥኱Ꮫᮾ኱㜰࢟ࣕࣥࣃࢫ㸪኱㜰ᗓᮾ኱㜰ᕷ18. ኱ሙᰟᶞ ࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ RubiconࡢⓎ⌧ᢚไࡣ㔝⏕ᆺࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢᑑ࿨ࢆᘏ㛗ࡉࡏࡿ ➨ 29 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ 2019.8.4 ㏆␥኱Ꮫᮾ኱㜰࢟ࣕࣥࣃࢫ㸪኱㜰ᗓᮾ኱㜰ᕷ19. ኱ሙᰟᶞ ࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࢩࣙ࢘ࢪ
ࣙ࢘ࣂ࢚ࡢ⚄⤒⑕≧ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ Rubicon ࡢⓎ⌧ᢚไ࡟ࡼࡾᨵၿࡍࡿ ➨9 ᅇㄆ▱⑕◊✲ࢆ▱ࡿⱝᡭ◊✲⪅ࡢ㞟ࡲࡾ 2019.8.1 ࣍ࢸࣝ࣊ࣜࢸ࢖ࢪ࣭ࣜࢰ࣮ࢺ㸪ᇸ⋢┴⇃㇂ᕷ
20. Suzuki M. Proteostasis in aging and neurodegenerative diseases. ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭➨ 62 ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ 2019.7.25 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
21. *୕஬୍᠇ࠊ㧗ஂ㟼㤶 ࠊሯᮏ㞞⨾ࠊ᪂ぢ┤Ꮚ ࠊඵᏊⱥྖ GLP-1 ཷᐜయసື⸆ exendin-4 ࡟ࡼࡿ࣑࢚ࣜࣥ໬ಁ㐍ࡢᶵᵓゎᯒ ➨ 42 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2019.7.26 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
22. *Kazunori SangoࠊHidei YakoࠊAyako KatoࠊNaoko NiimiࠊShizuka TakakuࠊKoichi Kato Reduced
glycolysis-TCA cycle flux in IMS32 Schwann cells under high glucose and pyruvate-deficientconditions. 2019 ᖺᗘᅜ㝿ᮎᲈ⚄⤒Ꮫ఍ 2019.6.25 Genoa㸪Italy
23. Suzuki M, Oba M, Nagai Y, Fukui K, Sango K. Therapeutic effects of Rubicon knockdown in a
Drosophila model of polyglutamine disease. Keystone Symposia “Neurodegenerative Diseases:
New Insights and Therapeutic Opportunities”  2019.6.16㹼20 Keystone, CO, USA
24. ඵᏊⱥྖࠊຍ⸨ᩥᏊࠊ᪂ぢ┤Ꮚ ࠊ㧗ஂ㟼㤶 ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇  ࣋ࣥࣇ࢛ࢳ࢔࣑ࣥࡣ
㧗ࢢࣝࢥ࣮ࢫ࣭ࣆࣝࣅࣥ㓟Ḟஈୗ࡛ࡢࢩࣗ࣡ࣥ⣽⬊Ṛࢆᢚไࡍࡿ ➨ 62 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ 2019.5.23 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸪ᐑᇛ┴௝ྎᕷ25. ㉥ᕊ཭௦ ࠊ㧗ஂ㟼㤶 ࠊ㕥ᮌ࣐ࣜࠊ᪂ぢ┤Ꮚ ࠊඵᏊⱥྖࠊỌ஭ὒ௓ࠊ➉⏣⿱௓ࠊⓗሙᆂ୍㑻ࠊᕝᾉ኱἞ࠊᏱ㒔ᐑ୍඾ࠊ୕஬୍᠇ ࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄࢻ࡟ࡼࡿࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡
ࣥ⣽⬊Ṛㄏᑟࡢᶵᵓゎ᫂ ➨ 62 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ 2019.5.23 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸪ᐑᇛ┴௝ྎᕷ－ 117 －

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 3 ௳㸧
1.

୕஬୍᠇ ⢾ᒀ⑓࡜ࡑࡢྜే⑕ࡢࢧ࢖࢚ࣥࢫ㸸≉࡟⚄⤒㞀ᐖ࡟ࡘ࠸࡚ ᮾி⸆⛉኱Ꮫබ㛤ࢭ࣑ࢼ࣮ࠕ⚄⤒⏕≀Ꮫ IIࠖ≉ูㅮ⩏ 2019.12.24 ᮾி㒔

2.

୕஬୍᠇ ⢾ᒀ⑓࡜࠸ࢃࢀࡓࡽ㸽 ⅲᒣ⏕ᾭᏛ⩦ࢭ࣑ࢼ࣮ 2019.9.25 ᮾி㒔

3.

ඵᏊⱥྖ 㧗ࢢࣝࢥ࣮ࢫ࣭እᅉᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡟࠾ࡅࡿ⢾௦ㅰ㞀ᐖ࡜⣽⬊Ṛㄏᑟᶵᗎࡢゎ᫂ ➨ 797 ᅇ஑ᕞ኱Ꮫ⏕య㜵ᚚ་Ꮫ◊✲ᡤࢭ࣑ࢼ࣮ 2019.9.24 ⏕య㜵ᚚ་Ꮫ◊✲ᡤᮏ㤋 1 㝵఍㆟ᐊ㸪⚟ᒸ┴⚟ᒸᕷ

IV. ≉グ஦㡯࠙≉チᶒࠚ
1.

AR 㑇ఏᏊḞᦆ࣐࢘ࢫ⏤᮶ࢩࣗ࣡ࣥ⣽⬊ᰴ IKARS1, 㔝⏕ᆺ࣐࢘ࢫ⏤᮶ࢩࣗ࣡ࣥ⣽⬊ᰴIWARS1㸦ᮍⓎ⾲㸧࡟㛵ࡋ, Applied Biological Materials Inc. (Richmond, B.C., Canada) ࡜ࣛ࢖ࢭࣥࢫዎ⣙ (tangible materials license agreement) ⥾⤖ 2019.6.28

࠙ࡑࡢ௚ࠚ
1.

኱ሙᰟᶞ  2020.3.18 Ⱚᾆᕤᴗ኱Ꮫ⬻⛉Ꮫ࣭ࣛ࢖ࣇࢸࢡࣀࣟࢪ࣮◊✲ࢭࣥࢱ࣮ዡບ㈹ཷ
㈹

2.

኱ሙᰟᶞ  2020.3.18 Ⱚᾆᕤᴗ኱Ꮫࢩࢫࢸ࣒⌮ᕤᏛᑓᨷ㈹ཷ㈹3.

୕஬୍᠇ 2019.11.13 NHK ࣛࢪ࢜➨୍ᨺ㏦ࠕNHK ࢪ࣮ࣕࢼࣝࠖࢪ࣮ࣕࢼࣝ་⒪೺ᗣ࡟
ฟ₇ࡋࠊࠕྜే⑕ࡀᛧ࠸⢾ᒀ⑓ࠖ࡟ࡘ࠸࡚ゎㄝ

4.

኱ሙᰟᶞ  2019.9.30 ᪥ᮏᏛ⾡᣺⯆఍≉ู◊✲ဨ (DC1) ࡟᥇⏝ෆᐃ

5.

኱ሙᰟᶞ  2019.8.3 ➨ 29 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ Ꮫ㒊⏕࣭ಟኈᏛ⏕ࢭࢵࢩࣙࣥඃ⚽㈹ཷ㈹－ 118 －

ࣉࣟࢪ࢙ࢡࢺྡ

⺮ⓑ㉁௦ㅰ◊✲ᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T,
Baumeister W, Fernandez-Busnadiego R, *Tanaka K, *Saeki Y. (2020) Stress- andubiquitylation-dependent phase separation of the proteasome. Nature 578, 296-300.

2.

Sato Y, Tsuchiya H, Yamagata A, Okatsu K, Tanaka, K, *Saeki Y, *Fukai S. (2019) Structural
insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat. Commun. 10, 5708.

3.

*Nishiyama A, Mulholland C, Bultmann S, Kori A, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y,
Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, *Arita K,*Leonhardt H, *Nakanishi M. (2020) Two distinct modes of DNMT1 recruitment ensure the stable
maintenance DNA methylation. Nat. Commun. 11, 1222.

4.

Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi
K, Iwasaki S, Saeki Y, Becker T, *Beckmann R, *Inada T. (2020) RQT complex dissociates
ribosomes collided on endogenous RQC substrate SDD1. Nat. Stuct. Mol. Biol., 27, 323-332.

5.

Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, *Beckmann R,*Inada T. (2019) Collided ribosomes form a unique structural interface to induce Hel2-driven
quality control pathways. EMBO J. 38, e100276.

6.

*Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C. (2019) Stepwise
multipolyubiquitantion of p53 by the E6AP-E6 ubiquitin ligase complex. J. Biol. Chem. 294,
14860-14875.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 6 ௳㸧
1.

Ohtake F, Tsuchiya H, Tanaka K, *Saeki Y. (2019) Methods to measure ubiquitin chain length andlinkage. Methods Enzymol. 618, 105-133.㸦ᰝㄞ࠶ࡾ㸧

2.

Yoshida Y, Saeki Y, Tsuchiya H, *Tanaka K. (2019) TR-TUBE system: Method for detecting
ubiquitination activity and identifying ubiquitinated substrates. Methods Enzymol. 618, 135-147.
㸦ᰝㄞ࠶ࡾ㸧

3.

*బ఑Ὀ ᩥ㒊⛉Ꮫ┬⛉◊㈝⿵ຓ㔠᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥ
ࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖࢽ࣮ࣗࢫࣞࢱ࣮➨ 1 ྕࠊ2019 ᖺ 6 ᭶ 1 ᪥Ⓨ⾜

4.
5.
6.

*బ఑Ὀࠕ᭱ඛ➃ࣉࣟࢸ࣑࢜ࢡࢫゎᯒࢆ⏝࠸ࡓࣘࣅ࢟ࢳࣥ◊✲ࠖࣇ࢓࣐ࣝࢩ࢔ࠊ᪥ᮏ⸆Ꮫ
఍ࠊ➨ 56 ᕳ➨ 1 ྕ 21㸫25 (2020)㸦ᰝㄞ࠶ࡾ㸧
ᅵᒇගࠊ*బ఑Ὀ ࠕ⣽⬊ෆࡢࣘࣅ࢟ࢳࣥ㙐㛗ゎᯒࠖ⏕໬Ꮫࠗ㠀ᐃᆺᆺࣘࣅ࢟ࢳࣥ㙐ࡢ⏕⌮ᶵ⬟࠘➨ 92 ᕳ➨ 1 ྕ 14㸫19 (2020㸧㸦ᰝㄞ࠶ࡾ㸧
Ᏻ⏣ࡉࡸ㤶ࠊ⏣୰ၨ஧ࠊ*బ఑Ὀࠕࢱࣥࣃࢡ㉁ࡢ࣐ࣝࢳࣂࣞࣥࢺ┦஫స⏝ࡀ㥑ືࡍࡿᾮ㸫ᾮ┦ศ㞳ࠖᐇ㦂་Ꮫ ⨺ᅵ♫ࠊ➨ 38 ᕳ➨ 5 ྕ 756㸫761 (2020)－ 119 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 11 ௳㸧
1.

Saeki Y Stress- and ubiquitylation-dependent phase separation of the proteasome. ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ࢩ࣏ࣥࢪ࣒࢘ 2019.12.4 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ

2.

బ఑Ὀ 㧗ᾐ㏱ᅽࢫࢺࣞࢫ࡟ࡼࡿࣉࣟࢸ࢔ࢯ࣮࣒ᾮ⁲ᙧᡂ࡜᰾ෆࢱࣥࣃࢡ㉁ศゎ ➨ 14 ᅇ᪥ᮏ⮫ᗋࢫࢺࣞࢫᛂ⟅Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ 2019.11.2 ኱㜰ᕷ❧኱Ꮫ㜿ಸ㔝࢟ࣕࣥࣃࢫ㸪኱㜰ᗓ኱㜰ᕷ

3.

Keiji Tanaka The Proteasome : Stress and Phase Separation 2019 NIH - Japan – JSPS
symposium 2019.10.28 Maryland, U.S.A.

4.

*బ఑Ὀ MS ࢆ⏝࠸ࡓࣘࣅ࢟ࢳࣥࢩࢢࢼࣝࡢ⥙⨶ⓗゎᯒ ➨ 11 ᅇ LC㸭MS ࣮࣡ࢡࢩࣙࢵࣉ
2019.10.24 ὾ྡ†ࣟ࢖ࣖࣝ࣍ࢸࣝ㸪㟼ᒸ┴὾ᯇᕷ

5.

*బ఑Ὀࠊᅵᒇගࠊ㐲⸨ᙯ๎ࠊ኱➉ྐ᫂ ࣘࣅ࢟ࢳࣥ࡟ࡼࡿࢱࣥࣃࢡ㉁ศゎࡢࡋࡃࡳ㸸We
will degrade you ! ➨ 9 ᅇ CSJ ໬Ꮫࣇ࢙ࢫࢱ 2019 2019.10.15~10.17 ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ㸪ᮾி㒔ᩥி༊

6.

బ఑Ὀ ࣉࣟࢸ࢔ࢯ࣮࣒ᾮ⁲࡟ࡼࡿ᰾ෆࢱࣥࣃࢡ㉁ศゎ ➨ 92 ᅇ⏕໬Ꮫ఍኱఍ࢩ࣏ࣥࢪ
࣒࢘ 2019.9.20 ࣃࢩࣇ࢕ࢥᶓ὾, ⚄ዉᕝ┴ᶓ὾ᕷ

7.

బ఑Ὀ Orbitrap Fusion Lumos ࢆ౑ࡗࡓ㠉᪂ⓗࣘࣅ࢟ࢳࣥ◊✲ ࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖࢚ࣥࢸ
࢕ࣇ࢕ࢵࢡ ㉁㔞ศᯒࣇ࢛࣮࣒ࣛ 2019 2019.8.2 ᮾிࢥࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮㸪ᮾி㒔ရᕝ༊

8.

బ఑Ὀ Orbitrap Fusion Lumos ࢆ౑ࡗࡓ㠉᪂ⓗࣘࣅ࢟ࢳࣥ◊✲ ࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖
࢚ࣥࢸ࢕ࣇ࢕ࢵࢡ ㉁㔞ศᯒࣇ࢛࣮࣒ࣛ 2019 2019.7.19 ࢖ࣥࢱ࣮ࢥࣥࢳࢿࣥࢱࣝ࣍ࢸࣝ
኱㜰㸪኱㜰ᗓ኱㜰ᕷ

9.

బ఑Ὀ ࣘࣅ࢟ࢳࣥ◊✲ࡢ᪂ᒎ㛤㸫┦ศ㞳࠿ࡽศゎㄏᑟ๣ࡲ࡛ ➨ 19 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍࣭➨ 71 ᅇ᪥ᮏ⣽⬊⏕≀Ꮫ఍኱఍ྜྠᖺḟ኱఍ 2019.6.25 ⚄ᡞᅜ㝿఍㆟ሙ௚㸪රᗜ┴⚄ᡞᕷ

10. 㐲⸨ᙯ๎ࠊ⚟ᔱಇ᫂ࠊబ఑Ὀࠊ⏣୰ၨ஧ࠊ㥖⏣㞞அ ⬺ࣘࣅ࢟ࢳࣥ໬㓝⣲ USP8 ࡟ࡼࡿ࢚ࣥࢻࢯ࣮࣒ࢫࢺࣞࢫไᚚ ➨ 19 ᅇ ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍࣭➨ 71 ᅇ᪥ᮏ⣽⬊⏕≀Ꮫ఍኱఍ ྜྠᖺḟ኱఍ 2019.6.25 ⚄ᡞᅜ㝿఍㆟ሙ௚㸪රᗜ┴⚄ᡞᕷ
11. బ఑Ὀࠊ㐲⸨ᙯ๎ࠊᅵᒇගࠊ኱➉ྐ᫂ ࢣࣔࢸࢡࣀࣟࢪ࣮࡜㉁㔞ศᯒィࢆά⏝ࡋࡓࣘࣅ࢟
ࢳࣥࢥ࣮ࢻࡢゎㄞ ᪥ᮏࢣ࣑࢝ࣝࣂ࢖࢜ࣟࢪ࣮Ꮫ఍➨ 14 ᅇᖺ఍ 2019.6.11 ࢘࢖ࣥࢡឡ
▱㸪ឡ▱┴ྡྂᒇᕷ
ࡑࡢ௚ 㸦ィ 15 ௳㸧⮬⏤ᥖ㍕
1.

㐲⸨ᙯ๎ In-depth ᐃ㔞ࣉࣟࢸ࣮࣒࢜ゎᯒࢆ⏝࠸ࡓࣘࣅ࢟ࢳࣥ◊✲ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࣘࣅ࢟ࢳࣥࠖ➨ 3 ᅇ⌜఍㆟ 2019.12.17㹼12.19 ࣍ࢸࣝ㸤ࣜࢰ࣮ࢶ༡ᡣ⥲㸪༓ⴥ┴༡ᡣ⥲ᕷ

2.

బ఑Ὀ ࢣࣔࢸࢡࣀࣟࢪ࣮࡜㉁㔞ศᯒィࢆά⏝ࡋࡓࣘࣅ࢟ࢳࣥࢥ࣮ࢻࡢゎㄞ 2019.12.17
㹼12.19 ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࣘࣅ࢟ࢳࣥࠖ➨ 3 ᅇ⌜఍㆟ ࣍ࢸࣝ㸤ࣜࢰ࣮ࢶ༡ᡣ⥲㸪༓ⴥ┴༡ᡣ⥲ᕷ

3.

ᅵᒇගࠊᏳ⏣ࡉࡸ㤶ࠊᾏಖឡࠊQiang Guoࠊụෆ೺ࠊ㐲⸨ᙯ๎ࠊ᪂஭┤Ꮚࠊ኱➉ྐ᫂ࠊᮧ⏣ⱱ✑ࠊ✄⏣฼ᩥࠊWolfgang BaumeisterࠊRuben Fernandez-Busnadiegoࠊ⏣୰ၨ஧ࠊబ఑Ὀ
ࢫࢺࣞࢫ౫Ꮡⓗ࡞ࣉࣟࢸ࢔ࢯ࣮࣒ᾮ㸫ᾮ┦ศ㞳 ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࣘࣅ࢟ࢳࣥࠖ➨ 3ᅇ⌜఍㆟ 2019.12.17㹼12.19 ࣍ࢸࣝ㸤ࣜࢰ࣮ࢶ༡ᡣ⥲㸪༓ⴥ┴༡ᡣ⥲ᕷ

－ 120 －

4.

Ᏻ⏣ࡉࡸ㤶ࠊᅵᒇග*ࠊᾏಖឡࠊQiang Guoࠊụෆ೺ࠊ㐲⸨ᙯ๎ࠊ᪂஭┤Ꮚࠊ኱➉ྐ᫂ࠊᮧ⏣ⱱ✑ࠊ✄⏣฼ᩥࠊWolfgang BaumeisterࠊRuben Fernandez-Busnadiegoࠊ⏣୰ၨ஧ࠊబ఑Ὀ
ࢫࢺࣞࢫ౫Ꮡⓗ࡞ࣉࣟࢸ࢔ࢯ࣮࣒ᾮ㸫ᾮ┦ศ㞳 ➨ 4 ᅇ LLPS ◊✲఍ 2019.12.9 ዉⰋ┴❧་⛉኱Ꮫ⮫ᗋ◊✲ࢭࣥࢱ࣮㸪ዉⰋ┴᷃ཎᕷ

5.

బ఑Ὀ ࢫࢺࣞࢫ࡜ࣘࣅ࢟ࢳࣥ࡟౫Ꮡࡋࡓࣉࣟࢸ࢔ࢯ࣮࣒ࡢᾮ㸫ᾮ┦ศ㞳 ➨ 42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ

6.

బ఑Ὀ 㧗ᾐ㏱ᅽࢫࢺࣞࢫ࡟ࡼࡿࣉࣟࢸ࢔ࢯ࣮࣒ᾮ⁲ᙧᡂ࡜᰾ෆࢱࣥࣃࢡ㉁ศゎ ➨ 14 ᅇ᪥ᮏ⮫ᗋࢫࢺࣞࢫᛂ⟅Ꮫ఍ 2019.11.2㹼11.3 ኱㜰ᕷ❧኱Ꮫ㜿ಸ㔝࢟ࣕࣥࣃࢫ㸪኱㜰ᗓ኱㜰ᕷ

7.

Sayaka Yasudaࠊ*Hikaru TsuchiyaࠊAi KaihoࠊKen IkeushiࠊAkinori EndoࠊFumiaki Ohtakeࠊ
Shigeo MurataࠊToshifumi InadaࠊKeiji TanakaࠊYasushi Saeki Stress and ubiquitylation dependent phase separation of the proteasomeEMBO Workshop The Ubiquitin system :Biology, mechanisms and roles 2019.9.13㹼9.17 Hotel Croatia Cavtat, Cavtat, Croatia
8.

*Fumiaki OhtakeࠊMikihiko NaitoࠊYasushi SaekiࠊKeiji Tanaka Proteomic analyses of the
K48/K63 branched ubiquitin chains  EMBO Workshop The Ubiquitin system : Biology,
mechanisms and roles 2019.9.13㹼9.17 Hotel Croatia Cavtat, Cavtat, Croatia

9.

*㐲⸨ᙯ๎ࠊ⚟ᔱಇ᫂ࠊబ఑Ὀࠊ⏣୰ၨ஧ࠊ㥖⏣㞞அ ⬺ࣘࣅ࢟ࢳࣥ໬㓝⣲ USP8 ࡟ࡼࡿ࢚ࣥࢻࢯ࣮࣒ࢫࢺࣞࢫไᚚ ➨ 19 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍࣭➨ 71 ᅇ᪥ᮏ⣽⬊⏕≀Ꮫ఍኱఍ྠྕᖺḟ኱఍ 2019.6.24㹼6.26 ⚄ᡞᅜ㝿఍㆟ሙ࣭⚄ᡞᅜ㝿ᒎ♧ሙ㸪රᗜ┴⚄ᡞᕷ

10. *Ᏻ⏣ࡉࡸ㤶ࠊᅵᒇගࠊ⏣୰ၨ஧ࠊబ఑Ὀ ࢩࣕࢺࣝศᏊ࡜ࣘࣅ࢟ࢳࣥ㙐ࡢᾮ㸫ᾮ┦ศ㞳
➨ 19 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍ 2019.6.24㹼6.26 ⚄ᡞᅜ㝿఍㆟ሙ㸪රᗜ┴⚄ᡞᕷ
11. బ఑Ὀ ࣘࣅ࢟ࢳࣥ◊✲ࡢ᪂ᒎ㛤㸫┦ศ㞳࠿ࡽศゎㄏᑟ๣ࡲ࡛ ➨ 19 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍࣭➨ 71 ᅇ᪥ᮏ⣽⬊⏕≀Ꮫ఍኱఍ྠྕᖺḟ኱఍ 2019.6.24㹼6.26 ⚄ᡞᅜ㝿఍㆟ሙ࣭⚄ᡞᅜ㝿ᒎ♧ሙ㸪රᗜ┴⚄ᡞᕷ12. Ᏻ⏣ࡉࡸ㤶ࠊᅵᒇගࠊబ఑Ὀࠊ*⏣୰ၨ஧ Phase separated proteasome condensates for nuclear
proteolysis ➨ 19 ᅇ᪥ᮏ⺮ⓑ㉁⛉Ꮫ఍ᖺ఍ 2019.6.24㹼6.26 ⚄ᡞᅜ㝿఍㆟ሙ㸪රᗜ┴⚄ᡞᕷ
13. బ఑Ὀ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࣘࣅ࢟ࢳࣥࠖࡀ┠ᣦࡍࡶࡢ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀ
ࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖ➨ 2 ᅇ⌜఍㆟ 2019.6.22 ᮾி኱Ꮫ᝟ሗᏛ
⎔࣭⚟Ṋ࣮࣍ࣝ㸪ᮾி㒔ᩥி༊
14. *బ఑Ὀࠊ㐲⸨ᙯ๎ࠊᅵᒇගࠊ኱➉ྐ᫂ ࢣࣔࢸࢡࣀࣟࢪ࣮࡜㉁㔞ศᯒィࢆά⏝ࡋࡓࣘࣅ࢟ࢳࣥࢥ࣮ࢻࡢゎㄞ ➨ 14 ᅇ᪥ᮏࢣ࣑࢝ࣝࣂ࢖࢜ࣟࢪ࣮Ꮫ఍ᖺ఍ 2019.6.10㹼6.12 ࢘࢖ࣥࢡ࠶࠸ࡕ㸪ឡ▱┴ྡྂᒇᕷ15. ኱➉ྐ᫂ ㉁㔞ศᯒᢏ⾡࡜ࢣ࣑࢝ࣝࢶ࣮ࣝࢆ฼⏝ࡋ࡚ࣘࣅ࢟ࢳࣥࢥ࣮ࢻࡢ」㞧ᛶ࡟ᣮࡴ
➨ 4 ᅇඛ➃ࢣ࣑࢝ࣝࣂ࢖࢜ࣟࢪ࣮◊✲఍ 2019.6.9 ྡྂᒇ኱Ꮫ ITbM ࣞࢡࢳ࣮࣮࣒ࣕࣝ㸪ឡ▱┴ྡྂᒇᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯࡞ࡋ－ 121 －

ࣉࣟࢪ࢙ࢡࢺྡ

⣽⬊⭷◊✲ᐊ

, ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ  ௳㸧 0RUL$+DWDQR7,QRVKLWD76KLED)XNXVKLPD..RLQXPD70HQJ+.XER66SUDWW6&XL&<DPDVKLWD & 0LNL < <DPDPRWR . +LUDED\DVKL 7 0XUDNDPL 0 7DNDKDVKL < 6KLQGRX +
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KWWSVZZZMFLRUJDUWLFOHVYLHZ
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 .DVDKDUD./LSLG5DIWV+HWHURJHQHLW\7UHQG*O\FRVFL*O\FRWHFK  6(
 +LUDED\DVKL70XUDNDPL0.LKDUD$7KHUROHRI313/$LQȦ2DF\OFHUDPLGHV\QWKHVLVDQG
VNLQEDUULHUIXQFWLRQ%LRFKLP%LRSK\V$FWD0RO&HOO%LRO/LSLGV
 ヨᩱศᯒㅮᗙ࣭⢾㉁ศᯒ 4.」ྜ⢾㉁ࡢศᯒ 4.3.⢾⬡㉁㸦ᕝᓥ⫱ኵࠊඡᕝᛅ㟹㸧pp138-158 4.4.
࣏ࣜከ⢾㸦ᕝᓥ⫱ኵࠊඡᕝᛅ㟹㸧pp159-164 2019.6.30 ᪥ᮏศᯒ໬Ꮫ఍⦅

୸ၿฟ∧ᰴᘧ఍♫,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ᖹᯘဴஓࠊṊᕷᣅஓࠊ➟ཎᾈ஧ࠊ$ODQ5%UDVKࠊᮧୖㄔࠊ⛅ᒣ┿ᚿ ࢔ࢩࣝࢭ࣑ࣛࢻ௦ㅰ
ࢆ௓ࡋࡓ⓶⭵ࣂࣜ࢔ᙧᡂᶵᵓ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ Ḉᗞᆒࠊඡᕝᛅ㟹ࠊ᭶ᮧ⪃ᏹࠊᚿ㈡ᬛᏊࠊṊ஭ຍዉᏊࠊ㰻⸨㟼ྖࠊᕝᓥ⫱ኵࠊ⏣ᓥ㝧୍  ᨵ
ኚᆺ 1$*$ ࢆ⏝࠸ࡓ᪂つࣇ࢓ࣈ࣮ࣜ⑓㓝⣲⿵඘⒪ἲࡢ㛤Ⓨ ➨  ᅇ᪥ᮏඛኳ௦ㅰ␗ᖖᏛ
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᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ 㹼 ᅜ❧ி㒔ᅜ㝿఍㤋㸪ி㒔ᗓி㒔ᕷ

－ 122 －

 ᑠᯇ㇂ၨ௓ࠊ஭ཱྀᬛᘯࠊᕝᓥ⫱ኵࠊᑠ಴₩ࠊ㟖⏣㟹ࠊ➟ཎᾈ஧ ᑠ⬻㢛⢏⣽⬊࡟࠾ࡅࡿ*3, ࢔࣮ࣥ࢝ᆺ⚄⤒⣽⬊᥋╔ศᏊ 1% ࡢ *'E ࣛࣇࢺࢆ௓ࡋࡓࢩࢢࢼࣝఏ㐩ᶵᵓࡢゎ᫂➨  ఍᪥ᮏ⏕໬Ꮫ఍ᖺ఍  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ ᱱ㝣ఀ㡩ࠊ୕ᮌᑑ⨾ࠊᖹᯘဴஓࠊᖹᐙᆂዉᏊࠊᑠᯘဴᖾࠊᒣᮏᆂࠊṊᐩⰾ㝯ࠊ㧗ᐑ㔛ዉࠊᮧୖㄔ ⓶⭵࡟࠾ࡅࡿ᪂つ⣽⬊㉁ᆺ࣍ࢫ࣍ࣜࣃ࣮ࢮ $ F3/$G F3/$H ࡢᶵ⬟ゎᯒ ➨ ఍᪥ᮏ⏕໬Ꮫ఍ᖺ఍  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ  ⚟ᒣ⨾ᬛᏊࠊ஭ཱྀᬛᘯࠊᑠᯇ㇂ၨ௓ࠊᕝᓥ⫱ኵࠊୗ௰ᇶஅࠊ✀Ꮚᓥᖾ♸ࠊཎᏕᙪࠊᒣᮏṇ㞞ࠊ➟ཎᾈ஧ ࢣࣔ࢝࢖ࣥ 6')Ș࡟ࡼࡿ -XUNDW7 ⣽⬊⛣ືࡢ⬡㉁ࣛࣇࢺࢆ௓ࡍࡿࢩࢢࢼ
ࣝఏ㐩 ➨  ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹼  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ ୕ᾆ㔛⧊ࠊ㇏ᕝ┿ᘯࠊᑠᕝ୍ⱥࠊ୕㜰ᬛྐࠊ⩏ஂ⢭⮧ࠊ➉▼ᜤ▱ࠊ➟ཎᾈ஧ࠊᒣᮏṇ㞞ࠊ໭∎ࡋࡢࡪ ࢔࣑ࣟ࢖ࢻș๓㥑ࢱࣥࣃࢡ㉁  ࡣ⾑ᑠᯈάᛶ໬࣐࣮࣮࢝࡜ࡋ࡚᭷⏝࠿㸽➨  ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 㹼  ࣃࢩࣇ࢕ࢥᶓ὾㸪⚄ዉᕝ┴ᶓ὾ᕷ ᑠᯇ㇂ၨ௓ࠊ஭ཱྀᬛᘯࠊᕝᓥ⫱ኵࠊᑠ಴₩ࠊᮡᾆಙኵࠊ๓⏣ಙ᫂ࠊ㟖⏣㟹ࠊ➟ཎᾈ஧ ᑠ⬊㢛⢏⣽⬊࢞ࣥࢢࣜ࢜ࢩࢻ *' ࡜ *'E ࡢ≉␗ⓗࢩࢢࢼࣝఏ㐩ࡢ୰⥅Ⅼ࡜ࡋ࡚ࡢᶵ⬟➨  ᅇ᪥ᮏ⢾㉁Ꮫ఍ᖺ఍ 㹼 ྡྂᒇ኱Ꮫ㇏⏣ㅮᇽ㸪ឡ▱┴ྡྂᒇᕷ ᕝཱྀ⯙ࠊᖹᯘဴஓࠊ➟ཎᾈ஧ࠊᮧୖㄔ 313/$313/$ ࢆ௓ࡋࡓෆᅉᛶࢥࣜࣥ⏘⏕⤒㊰ࡣ⫢⮚ࡢ࣓ࢳࣝᇶ౪⤥࡟ᐤ୚ࡍࡿ ➨  ᅇ᪥ᮏ⬡㉁⏕໬Ꮫ఍  ໭ᾏ㐨኱ᏛᏛ⾡஺ὶ఍㤋㸪໭ᾏ㐨ᮐᖠᕷ .DZDJXFKL 0 +LUDED\DVKL 7 0XUDNDPL 0 3KRVSKDWLG\OFKROLQH EUHDNGRZQ E\ 313/$ DQG313/$VXSSOLHVPHWK\OJURXSVLQWKHOLYHUWK,QWHUQDWLRQDO&RQIHUHQFHRQWKH%LRVFLHQFHRI/LSLGV  ୍ࢶᶫ࣮࣍ࣝ㸪ᮾி㒔༓௦⏣༊ +DUDGD67DNHWRPL<.DZDJXFKL0+LUDED\DVKL70XUDNDPL07KHO\VRSKRVSKROLSDVH313/$
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&RQIHUHQFHRQWKH%LRVFLHQFHRI/LSLGV  ୍ࢶᶫ࣮࣍ࣝ㸪ᮾி㒔༓௦⏣༊ /LDQJ/+HLNH..RED\DVKL7+LUDED\DVKL70LNL<<DPDPRWR.7DNHWRPL<0XUDNDPL0
*URXS ,9( SKRVSKROLSDVH $

F3/$İ  PRELOL]HV WKH QRQFDQRQLFDO OLSLG PHGLDWRU

1DF\OHWKDQRODPLQH LQ PRXVH VNLQ WK ,QWHUQDWLRQDO &RQIHUHQFH RQ WKH %LRVFLHQFH RI /LSLGV ୍ࢶᶫ࣮࣍ࣝ㸪ᮾி㒔༓௦⏣༊,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧 ➟ཎᾈ஧ࠕ⢾⬡㉁࡜ࢭ࣑ࣛࢻࡢᶵ⬟ࠖ㧗ᰯ⏕ࣇ࢛࣮࣒ࣛㅮ⩏  ➟ཎᾈ஧ࠕ⢾⬡㉁࡜ࢭ࣑ࣛࢻࡢᶵ⬟ࠖ᫛࿴⸆⛉኱ᏛぢᏛᑐᛂ ㅮ⩏  ➟ཎᾈ஧ࠕ⣽⬊⭷࡟࠾ࡅࡿ⢾⬡㉁ࡢᶵ⬟ゎᯒࠖᡤෆ◊✲Ⓨ⾲఍㸦➨  㒊఍㸧 ᖹᯘဴஓࠕ⫢⮚ࡢ࣍ࢫࣇ࢓ࢳࢪࣝࢥࣜࣥศゎ⤒㊰ࡢᙺ๭ࠖᡤෆ◊✲Ⓨ⾲఍㸦➨  㒊఍㸧 ⚟ᒣ⨾ᬛᏊࠕࢣࣔ࢝࢖ࣥ 6')Ș࡟ࡼࡿ -XUNDW7 ⣽⬊⛣ືࡢ ࣊ࣃࣛࣥ◲㓟ࢆ௓ࡍࡿࢩࢢࢼ
ࣝఏ㐩ࠖᡤෆ◊✲Ⓨ⾲఍㸦➨  㒊఍㸧


,9 ≉グ஦㡯࠙≉チࠚ ᑠ಴₩ 3&7 ฟ㢪ࠕ+*)UHJXODWHGW\URVLQHNLQDVHVXEVWUDWH +*6 ࢆᶆⓗ࡜ࡋࡓ᪂つ⭘⒆ቑṪᢚไ๣ࠖ


－ 123 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࣃ࣮࢟ࣥࢯࣥ⑓◊✲ᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧ᰝㄞ࠶ࡾ1.

Sugama S, Takenouchi T, Hashimoto M, Ohata H, Takenaka Y, Kakinuma Y. Stress-Induced
Microglial Activation Occurs through ȕ-Adrenergic Receptor: Noradrenaline as a Key
Neurotransmitter in Microglial Activation J Neuroinflammation. 2019 Dec 17;16(1):266. doi:
10.1186/s12974-019-1632-z.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 6 ௳㸧ࡍ࡭࡚ᰝㄞ࠶ࡾ
1.

Takamatsu Y, Ho G, Hashimoto M. Amyloid Evolvability and Cancer. Trends Cancer 2020
5:S2405-8033(20)30122-9. doi: 10.1016/j.trecan.2020.04.001. Online ahead of print. PMID:
32386876

2.

Fujita M, Ho G, Takamatsu Y, Wada R, Ikeda K, Hashimoto M. Possible Role of Amyloidogenic
Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H
ȕ-Synuclein. Int J Mol Sci. 2020 9;21(8):2849. doi: 10.3390/ijms21082849. PMID: 32325870 Free
PMC article.

3.

Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M.
Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability? Front
Endocrinol (Lausanne). 2020 4;11:108. doi: 10.3389/fendo.2020.00108. eCollection 2020. PMID:
32194507 Free PMC article.

4.

Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E.
Possible role of amyloid cross-seeding in evolvability and neurodegenerative diseases. J
Parkinsons Dis. 2019;9(4):793-802. doi: 10.3233/JPD-191675.

5.

Ho G, Takamatsu Y, Waragai M, Wada R, Sugama S, Takenouchi T, Fujita M, Ali A, Hsieh MH,
Hashimoto M. Current and future utilities of Parkinson’s disease biomarkers: can they help us
conquer the disease? Expert Rev Neurother.2019 19(11):1149-1161. doi: 10.1080/14737175.
2019.1649141.

6.

Takamatsu Y, Ho G, Waragai M, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M.
Transgenerational interaction of Alzheimer’s disease with Schizophrenia through amyloidogenic
evolvability. J Alzheimers Dis. 2019;68(2):473-481. doi: 10.3233/JAD-180986.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋ

－ 124 －

ࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ 㧗ᯇⰾᶞࠊ஭ୖ႐༤ࠊ࿴⏣ᾴᏊࠊ஭ୖ⪽ࠊᶫᮏḰ Șཪࡣșࢩࢾࢡࣞ࢖ࣥࡢ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢ⏘≀ࢆⓎ⌧ࡍࡿࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 
⚟ᒸᅜ㝿఍ሙ௚㸪⚟ᒸ┴⚟ᒸᕷ,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧࡞ࡋ,9 ≉グ஦㡯
࡞ࡋ
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－ 125 －

ࣉࣟࢪ࢙ࢡࢺྡ

ື≀ᐇ㦂㛤ⓎᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Yasuda SP, Seki Y, Suzuki S, Ohshiba Y, Hou X, Matsuoka K, Wada K, Shitara H, Miyasaka Y,
Kikkawa Y (2019) c.753A>G genome editing of a Cdh23ahl allele delays age-related hearing loss
and degeneration of cochlear hair cells in C57BL/6J mice. Hear Res. in press doi:
10.1016/j.heares.2020.107926.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕
࡞ࡋIII. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧࡞ࡋ

IV. ≉グ஦㡯࡞ࡋ－ 126 －

ࣉࣟࢪ࢙ࢡࢺྡ

I.

◊✲ᢏ⾡㛤Ⓨᐊㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Sekiyama K, Ushiro Y, Kurisaki A, Funaba M, Hashimoto O. (2019) Activin E Enhances Insulin
Sensitivity and Thermogenesis by Activating Brown/Beige Adipocytes. J Vet Med Sci.
11;81(5):646-652.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧࡞ࡋ

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧࡞ࡋࡑࡢ௚ 㸦ィ 9 ௳㸧⮬⏤ᥖ㍕
⏣୰༟ࠊ㮛᭸Ꮚࠊす⸨Ὀᫀࠊṇ஭ஂ㞝 ኱⭠⳦ࡢ multi-repliconᵝᘧ㛤ጞ࡟ᚲせ࡜ࡉࢀࡿࢤ
ࣀ࣒㓄ิ࡜ࡑࡢศᏊ࣓࢝ࢽࢬ࣒ ➨42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ┴⚟ᒸᕷᐑୗ▱அࠊ୕ୖᜤᖹࠊ㐲⸨ሀኴ㑻ࠊᐑᆅᏕ᫂ࠊ᳃ᒣబ࿴Ꮚࠊ௒㔝ᖾኴ㑻ࠊ᳃ᒣⰾ๎ࠊΏ㎶㞞ᙪࠊ㰺⸨ᐇ Ensheathing Glia࠿ࡽࡢᑠ⬊ᛶࢢࣝࢱ࣑ࣥ㓟ᨺฟࡀࠊ㐃ྜᏛ⩦࡟࠾ࡅࡿ᎘ᝏ
᝟ሗࢆఏ㐩ࡍࡿ ➨42 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2019.12.3㹼12.6 ⚟ᒸᅜ㝿఍㆟ሙ௚㸪⚟ᒸ
┴⚟ᒸᕷ



Kotajima H, Kobayashi T, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K(2019) mTOR signaling pathway plays a key role in non-syndromic autism spectrum disorder. 6th
Congress of Asian College of Neuropsychopharmacology (AsCNP2019) 2019.10.11 Fukuoka
International Congress Center,Fukuoka,Japan

Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino
S, Ikeda K (2019) Effects of rapamycin treatment on impaired social interaction and gene expression
in mice treated prenatally with valproic acid. The 10th IBRO World Congress of Neuroscience(IBRO2019) 2019.9.25 Daegu, Korea

኱ෆྐᏊࠊఀ⸨⩏ᇛࠊ୕ୖᜤᖹࠊᅵ஭ዉ✑Ꮚࠊ⛙຾ᚿࠊᑠ㔝ᘺᏊ ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕
࣮2A ᆺࣔࢹ࣐ࣝ࢘ࢫࡢ⤒᫬ⓗኚ໬ ᪥ᮏ➽Ꮫ఍➨5 ᅇᏛ⾡㞟఍ 2019.8.2㹼8.3 ఀ⸨ᅜ㝿Ꮫ⾡◊✲ࢭࣥࢱ࣮࣭ఀ⸨ㅰᜠ࣮࣍ࣝ㸪ᮾி㒔ᩥி༊ᐑୗ▱அࠊ୕ୖᜤᖹࠊ㐲⸨ሀኴ㑻ࠊᐑᆅᏕ᫂ࠊ᳃ᒣబ࿴Ꮚࠊ௒㔝ᖾኴ㑻ࠊ᳃ᒣⰾ๎ࠊΏ㎶－ 127 －

㞞ᙪࠊ㰺⸨ᐇ (QVKHDWKLQJ*OLD ࠿ࡽࡢᑠ⬊ᛶࢢࣝࢱ࣑ࣥ㓟ᨺฟࡀࠊ㐃ྜᏛ⩦࡟࠾ࡅࡿ᎘ᝏ
᝟ሗࢆఏ㐩ࡍࡿ 1(852㸦➨  ᅇ ᪥ᮏ⚄  ⤒⛉Ꮫ኱఍ࠊ ➨  ᅇ᪥ᮏ⚄⤒໬Ꮫ኱఍㸧 㹼 ᮒ㮛࣓ࢵࢭ㸪᪂₲┴᪂₲ᕷ
 .RWDMLPD0XUDNDPL+.RED\DVKL7.DVKLL+6DWR$+DJLQR<7DQDND01LVKLWR<7DNDPDWVX
<8FKLQR6,NHGD.  (IIHFWVRIUDSDP\FLQRQVRFLDOGHILFLWVDQGJHQHH[SUHVVLRQLQPLFHWUHDWHGSUHQDWDOO\ZLWKYDOSURLFDFLG1(852 㹼 7RNL0HVVH㸪1LLJDWD  ᯇᒸ㑥ᯞࠊ࿴⏣೺ኴࠊᐑᆏຬ㍤ࠊᏳ⏣ಇᖹࠊ㛵ඃኴࠊす⸨Ὀᫀࠊタᴦᾈᚿࠊከᒇ㛗἞ࠊྜྷᕝḠு ෆ⪥እ᭷ẟ⣽⬊ࡢ◚ቯ࡟ࡼࡿ㑇ఏᏊⓎ⌧ኚືࡢゎᯒ ➨  ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 㹼 ⚟ᒸᅜ㝿఍㆟ሙ㸪⚟ᒸ┴⚟ᒸᕷ ୕ୖᜤᖹ ࠕ᪋タ⤂௓ࠖ ➨  ᅇ㟁Ꮚ㢧ᚤ㙾ᢏ⾡◊✲఍  ᮾி኱Ꮫ་Ꮫ㒊ᩍ⫱◊✲Ჷ  㝵➨ ࣭➨  ࢭ࣑ࢼ࣮ᐊ㸪ᮾி㒔ᩥி༊,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧࡞ࡋ,9 ≉グ஦㡯
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ࣉࣟࢪ࢙ࢡࢺྡ

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 7DQLNDZD6.DWR<7DQLQR07HUDVDND6.XURNDZD<$UDL11DJDVKLPD.7DQDND6  $XWRSV\UHSRUWRIDODWHGHOD\HGUDGLDWLRQLQMXU\DIWHUDSHULRGRI\HDUV1HXURSDWKRORJ\
$SU  GRLQHXS
 0DNLQR<$UDL1+RVKLRND<<RVKLGD0.RMLPD0+RULNRVKL70XNDL+,ZDVH+  
7UDXPDWLFD[RQDOLQMXU\UHYHDOHGE\SRVWPRUWHPPDJQHWLFUHVRQDQFHLPDJLQJ/HJ0HG 7RN\R )HEGRLMOHJDOPHG
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ  ௳㸧 ᪂஭ಙ㝯 ࣐ࢡࣟ⚄⤒⑓⌮Ꮫ࢔ࢺࣛࢫ㸦་Ꮫ᭩㝔㸧,6%1㸦㸧 ᪂஭ಙ㝯  ୰ᯡ⚄⤒⣔ࡢ࣐ࢡࣟゎ๗㸬➨  ᅇ⚄⤒⑓⌮ࢥ࢔࣒࢝ࣜ࢟ࣗࣛᩍ⫱ࢭ࣑ࢼ࣮ࣁ
ࣥࢻ࢔࢘ࢺ S㸦㸧 ᪂஭ಙ㝯  ኚᛶ⑌ᝈࡢࡳ࠿ࡓ   ኚᛶ⑌ᝈࡢࡓࡵࡢษࡾฟࡋἲ㸬⑓⌮࡜⮫ᗋ㸦ᩥගᇽ㸧
9RO1RS±㸦㸧 㛵⤮㔛㤶  ➨  ᅇࢧࢡࣛ⑓⌮ᢏ⾡㈹ዡບ㈹ཷ㈹⪅⤂௓ +LVWR/RMLF -DSDQ 9RO 1R S㸦㸧 㛵⤮㔛㤶  ᶆᮏ㐨ሙ࣭ึᚰ⪅⦅ࠕ.% ᰁⰍࡢ⢭ᗘ⟶⌮ࡣ࡝ࡢࡼ࠺࡟ࡋࡓࡽࡼ࠸࡛ࡍ࠿ࠋ
KWWSVZZZVDNXUDILQHWHNFRPMDHGXFDWLRQGRXM\RX 㸦㸧 㛵⤮㔛㤶  ࣑ࢡ᳨ࣟ⣴ἲ²ྛ✀ᰁⰍἲ࡜⤌⧊ษ∦ࡢぢ᪉ ➨  ᅇ⚄⤒⑓⌮ࢥ࢔࢝ࣜ࢟ࣗ
࣒ࣛᩍ⫱ࢭ࣑ࢼ࣮ࣁࣥࢻ࢔࢘ࢺ S㸦㸧 㛵⤮㔛㤶  ኚᛶ⑌ᝈࡢࡳ࠿ࡓ  ⚄⤒ኚᛶ⑌ᝈ᳨⣴ࡢࡓࡵࡢᰁⰍ㑅ᢥ㸬⑓⌮࡜⮫ᗋ㸦ᩥගᇽ㸧9RO1RS±㸦㸧 ᪂஭ಙ㝯 ྖἲゎ๗౛ࡢ୰ᯡ⚄⤒⑓⌮ࡢ㚷ᐃ᭩సᡂ㸦㝶᫬㸧
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－ 129 －

,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧 ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢ᳨⣴ἲ ➨  ᅇ㒔❧⑓㝔ᰁⰍ᳨ウ఍  㥖㎸⑓㝔ู㤋ㅮᇽ ᮾி㒔ᩥி༊ 㛵⤮㔛㤶 ➨  ᅇࢧࢡࣛ⑓⌮ᢏ⾡㈹ཷ㈹グᛕ≉ูㅮ₇఍  ዴỈ఍㤋㸪ᮾி㒔༓௦⏣༊ ᪂஭ಙ㝯 ࣃ࣮࢟ࣥࢯࣥ⑓࠾ࡼࡧ㢮⦕⑌ᝈࡢ⚄⤒⑓⌮ ➨  ᅇරᗜ⮫ᗋ⚄⤒⑓⌮࢝ࣥࣇ࢓ࣞࣥࢫ  ⏕⏣⚄♫఍㤋㸪රᗜ┴⚄ᡞᕷ ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢ࣐ࢡࣟゎ๗ ➨  ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍Ꮫ⾡◊✲఍࣭➨  ᅇ⚄⤒⑓⌮ࢥ࢔࣒࢝ࣜ࢟ࣗࣛᩍ⫱ࢭ࣑ࢼ࣮  ࢘࢖ࣥࢡឡ▱㸪ឡ▱┴ྡྂᒇᕷ 㛵⤮㔛㤶 ࣑ࢡ᳨ࣟ⣴ἲ㸫ྛ✀ᰁⰍἲ࡜⤌⧊ษ∦ࡢぢ᪉ ➨  ᅇ᪥ᮏ⚄⤒⑓⌮Ꮫ఍Ꮫ⾡◊✲఍࣭➨  ᅇ⚄⤒⑓⌮ࢥ࢔࣒࢝ࣜ࢟ࣗࣛᩍ⫱ࢭ࣑ࢼ࣮  ࢘࢖ࣥࢡឡ▱㸪ឡ▱┴ྡྂᒇᕷ
ࡑࡢ௚ 㸦ィ  ௳㸧⮬⏤ᥖ㍕ ᪂஭ಙ㝯ࠊᑠᓥ฼㤶ࠊ㛵ᒣ୍ᡂࠊ᳜ᮌಙᏊࠊඵᮌ᭸Ꮚࠊᒣすᖖ⨾ࠊỤཱྀᘯ⨾ࠊ㛵⤮㔛㤶 Ꮫ⩦ຠ⋡ࢆྥୖࡉࡏࡿࢹࢪࢱࣝ⚄⤒⑓⌮ᐇ⩦ࡢ㐠⏝ ➨  ᅇ᪥ᮏ⑓⌮Ꮫ఍⥲఍ 
ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊ 㛵⤮㔛㤶ࠊᑠᓥ฼㤶ࠊ㛵ᒣ୍ᡂࠊ᳜ᮌಙᏊࠊඵᮌ᭸Ꮚࠊᒣすᖖ⨾ࠊỤཱྀᘯ⨾ࠊ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢデ᩿ຊྥୖ࡬ࡢྲྀࡾ⤌ࡳ࣭ࢹࢪࢱࣝᩍ⫱ࢶ࣮ࣝࡢ฼⏝ ➨  ᅇ᪥ᮏ⑓⌮Ꮫ఍⥲఍  ᮾிᅜ㝿ࣇ࢛࣮࣒ࣛ㸪ᮾி㒔༓௦⏣༊,,, ࡑࡢ௚ࡢⓎ⾲㸦ィ  ௳㸧 ᪂஭ಙ㝯 Ỉಛ⑓ࡢ⚄⤒⑓⌮ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢゎ๗࡜⑓⌮ ⇃ᮏ኱Ꮫ་Ꮫ㒊ㅮ⩏  ⇃ᮏ኱Ꮫ  ᪂஭ಙ㝯 ⬨㧊ࡢᙧែ࣭ᶵ⬟࡜⑌⑓ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ➨  ᅇ⚄⤒⑓⌮ຮᙉ఍ㅮᖌ  ᮾி㒔┘ᐹ་ົ㝔  ᮾி㒔ᩥி༊ ᪂஭ಙ㝯 ⬻ᖿࡢᙧែ࣭ᶵ⬟࡜⑌⑓ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢゎ๗࡜⑓⌮ ᶓ὾ᕷ❧኱Ꮫ་Ꮫ㒊ㅮ⩏  ⚄ዉᕝ┴ᶓ὾ᕷ ᪂஭ಙ㝯 ᑠ⬻ࡢᙧែ࣭ᶵ⬟࡜⑌⑓ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ୰ᯡ⚄⤒⣔ࡢゎ๗࡜⑓⌮ ᮾி་⒪Ꮫ㝔኱Ꮫㅮ⩏  ᮾி㒔ከᦶᕷ ᪂஭ಙ㝯 どぬࡢఏᑟ࡜ࡑࡢ㞀ᐖ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ᵝࠎ࡞࢘࢖ࣝࢫᛶ⬻⬨㧊⅖ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ⬻እ⛉἞⒪ࡀྍ⬟࡞ㄆ▱⑕ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 㢌㒊እയࡢ௒᪥ⓗヰ㢟 ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ➨  ᅇ⚄⤒⑓⌮ຮᙉ఍ㅮᖌ ᮾி㒔┘ᐹ་ົ㝔  ᮾி㒔ᩥி༊ ᪂஭ಙ㝯 ࣃ࣮࢟ࣥࢯࣥ⑓㛵㐃⑌ᝈ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ➽ⴎ⦰ᛶഃ⣴◳໬⑕ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ⬻ࡢᙧᡂ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊
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－ 130 －

 ᪂஭ಙ㝯 ࣈ࣮ࣟࢻ࣐ࣥ⬻ᆅᅗ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᑠᓥ฼㤶ࠊ㛵⤮㔛㤶ࠊỤཱྀᘯ⨾ࠊ᳜ᮌಙᏊࠊඵᮌ᭸Ꮚࠊᒣすᖖ⨾ࠊ᪂஭ಙ㝯 ᮾி㒔་Ꮫ◊࣭⬻⚄⤒⑓⌮ࢹ࣮ࢱ࣮࣋ࢫ  ᖺḟሗ࿌  ឡ▱┴ྡྂᒇᕷ
 ᪂஭ಙ㝯 ⬻⬨㧊࡬ࡢ⾑ᾮ౪⤥ࡢ௙⤌ࡳ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 እຊ࠿ࡽ⬻⬨㧊ࢆᏲࡿ௙⤌ࡳ ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ୰ᯡ⚄⤒࡜ᮎᲈ⚄⤒ࡢ༊ู ➨  ᅇ⚄⤒⑓⌮ࢡࣝࢬࢫ  ་Ꮫ◊ ᪂஭ಙ㝯 ⚄⤒⣔ࡢゎ๗࡜⑓⌮ ᫛࿴኱Ꮫ་Ꮫ㒊ㅮ⩏࣭ᐇ⩦ 
,9  ≉グ஦㡯 ᪂஭ಙ㝯 ᮾி་⛉኱Ꮫ୰㛗ᮇィ⏬እ㒊ホ౯ጤဨ఍㸦ጤဨ㸧 㛵⤮㔛㤶 ➨  ᅇࢧࢡࣛ⑓⌮ᢏ⾡㈹ዡບ㈹ࢆཷ㈹
 ᇸ⋢་⛉኱Ꮫ⑓⌮ࠊ໭ᾏ㐨኱Ꮫ⑓⌮ࠊ໭ᾏ㐨኱Ꮫ⚄⤒ෆ⛉ࠊᮥᯘ኱Ꮫ⑓⌮ࠊ㛗ᓮ኱Ꮫ⚄⤒ゎ๗࡟⚄⤒⑓⌮ H࣮ࣛࢽࣥࢢࢥࣥࢸࣥࢶࢆᥦ౪㸦฼⏝チㅙዎ⣙㸧 ⬻⚄⤒⑓⌮ࢹ࣮ࢱ࣮࣋ࢫⱥㄒ∧㸦(VVHQWLDO%UDLQ$QDWRP\ 1HXURSDWKRORJ\㸧ࡢ㜀ぴ࢔࢝࢘ࣥࢺࢆ⣙  ௳Ⓨ⾜－ 131 －

ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤᖺሗ㸦2020 ᖺ∧㸧2020 ᖺ 8 ᭶Ⓨ⾜⦅㞟࣭Ⓨ⾜ බ┈㈈ᅋἲே ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ      ࠛ156-8506 ᮾி㒔ୡ⏣㇂༊ୖ໭ἑ 2-1-6
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