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主な論文・著作・業績①Nasu, T., Satoh, M., Hachiya, T., Sutoh, Y., Ohmomo, H., Hitomi, S., Taguchi, S., Kikuchi, H., Kobayashi, T.,Takahashi, Y., Osaki, T., Morino, Y., Sobue, K., Shimizu, A., Sasaki, M., 2021. A genome-wide association study forhighly sensitive cardiac troponin T levels identified a novel genetic variation near a RBAK-ZNF890P locus in theJapanese general population. Int J Cardiol 329, 186–191. https://doi.org/10.1016/j.ijcard.2020.12.019②Sutoh, Y., Hachiya, T., Suzuki, Y., Komaki, S., Ohmomo, H., Kakisaka, K., Wang, T., Takikawa, Y., Shimizu, A.,
2020. ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among
middle-aged Japanese men: a genome-wide G × E interaction analysis. Sci Rep 10, 16227.
https://doi.org/10.1038/s41598-020-73263-1

いわて東北須藤洋一

メディカル・メガバンク機構特命准教授

博士（医学）

免疫学③Suzuki, S., Goto, A., Nakatochi, M., Narita, A., Yamaji, T., Sawada, N., Katagiri, R., Iwagami, M., Hanyuda, A.,

進化生物学

Hachiya, T., Sutoh, Y., Oze, I., Koyanagi, Y.N., Kasugai, Y., Taniyama, Y., Ito, H., Ikezaki, H., Nishida, Y., Tamura, T.,

分子生物学

Mikami, H., Takezaki, T., Suzuki, S., Ozaki, E., Kuriki, K., Takashima, N., Arisawa, K., Takeuchi, K., Tanno, K.,
Shimizu, A., Tamiya, G., Hozawa, A., Kinoshita, K., Wakai, K., Sasaki, M., Yamamoto, M., Matsuo, K., Tsugane, S.,
Iwasaki, M., 2021. Body mass index and colorectal cancer risk: A Mendelian randomization study. Cancer Sci 112,1579–1588. https://doi.org/10.1111/cas.14824④Zempo, H., Kim, S.-J., Fuku, N., Nishida, Y., Higaki, Y., Wan, J., Yen, K., Miller, B., Vicinanza, R., Miyamoto-Mikami,E., Kumagai, H., Naito, H., Xiao, J., Mehta, H.H., Lee, C., Hara, M., Patel, Y.M., Setiawan, V.W., Moore, T.M.,
Hevener, A.L., Sutoh, Y., Shimizu, A., Kojima, K., Kinoshita, K., Arai, Y., Hirose, N., Maeda, S., Tanaka, K., Cohen, P.,
2021. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY)
13, 1692–1717. https://doi.org/10.18632/aging.202529

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主な論文・著作・業績①High-Output Heart Failure Caused by Femoral Arteriovenous Fistula 27 Years After Trauma. Yuki Matsumoto,
MD; Keiko Tsuji, MD; Takuya Osaki, MD; Shigeto Tsuji, MD; Junichi Tsuboi, MD; Hajime Kin, MD; Yoshihiro
Morino, MD. VASCULAR DISEASE MANAGEMENT 2021;18(4):E52-E55.
②Impact of the Great East Japan Earthquake and Tsunami on the Incidence of Takotsubo Syndrome Using a
Multicenter, Long-Term Regional Registry.Tomonori Itoh, MD; Nozomu Toda, MD; Michiko Yoshizawa, MD; Takuya
Osaki, MD; Yuko Maegawa, MD; Reisuke Yoshizawa, MD; Yu Ishikawa, MD; Osamu Nishiyama, MD; Satoshi
Nakajima, MD; Motoyuki Nakamura, MD; Yoshihiro Morino, MD Circ J. 2021 Sep 24;85(10):1834-1839. doi:
10.1253/circj.CJ-20-1044. Epub 2021 Jun 12.
③Impact of East Japan Earthquake Disaster with Massive Tsunami for Prevalence of Takotsubo Syndrome -A
Multicenter Regional Registry before and after East Japan Earthquake Disaster
European Society of Cardiology Congress 2020.

いわて東北大﨑拓也

メディカル・メガバンク機構

特命助教博士(医学)

循環内科学

Tomonori Itoh MD, Nozomu Toda MD, Takuya Osaki MD, Yuko Maegawa MD, Reisuke Yoshizawa MD, YuIshikawa MD Osamu Nishiyama MD, Michiko Yoshizawa MD, Satoshi Nakajima MD, Motoyuki Nakamura MD,
Yoshihiro Morino MD. On-Demand :28 Aug 2020.
④Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general
Japanese population: Results from the Tohoku Medical Megabank ProjectYuji Takahashi, Mamoru Satoh, Hideki Ohmomo, Fumitaka Tanaka, Takuya Osaki, Kozo Tanno, Takahito Nasu,Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue & Makoto Sasaki Biomarkers. Accepted author version posted
online: 12 Apr 2019.
⑤Takuya Osaki, Mamoru Satoh, Fumitaka Tanaka, Kozo Tanno, Yuji Takahashi, Takahito Nasu, Kiyomi Sakata,
Yoshihiro Morino, Kenji Sobue, and Makoto Sasaki. The Value of a Cystatin C-based Estimated GlomerularFiltration Rate for Cardiovascular Assessment in a General Japanese Population:Results From the Iwate Tohoku
Medical Megabank Project. J Epidemiol 2020;30(6):260-267.

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主な論文・著作・業績①Sakashita T, Nakamura Y, Sutoh Y, Shimizu A, Hachiya T, Otsuka-Yamasaki Y, Takashima N, Kadota A, Miura K,Kita Y, Ikezaki H, Otonari J, Tanaka K, Shimanoe C, Koyama T, Watanabe I, Suzuki S, Nakagawa-Senda H, Hishida
A, Tamura T, Kato Y, Okada R, Kuriki K, Katsuura-Kamano S, Watanabe T, Tanoue S, Koriyama C, Oze I, Koyanagi
YN, Nakamura Y, Kusakabe M, Nakatochi M, Momozawa Y, Wakai K, Matsuo K. Comparison of the loci associatedwith HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population.
Diabetol Int. 2023 Jan 27;14(2):188-198. doi: 10.1007/s13340-023-00618-0. PMID: 37090135; PMCID:PMC10113415.

いわて東北山崎弥生

メディカル・特命助教

博士（獣医学）メガバンク機構

獣医内科学（血液②Ohbe H, Hachiya T, Yamaji T, Nakano S, Miyamoto Y, Sutoh Y, Otsuka-Yamasaki Y, Shimizu A, Yasunaga H,病・人獣共通感染

Sawada N, Inoue M, Tsugane S, Iwasaki M; Japan Public Health Center-based Prospective Study Group.

症）

Development and validation of genome-wide polygenic risk scores for predicting breast cancer incidence in

分子生物学Japanese females: a population-based case-cohort study. Breast Cancer Res Treat. 2023 Feb;197(3):661-671. doi:
10.1007/s10549-022-06843-6. Epub 2022 Dec 20. PMID: 36538246.
③Chen Y, Miyazono K, Otsuka Y., Kanamori M, Yamashita A, Arashiki N, Matsumoto T, Takada K, Sato K,Mohandas N, Inaba M. Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for
ellipsoidal camelid red cells with decreased deformability. The Journal of biological chemistry 2023
Feb;299(2):102877. doi: 10.1016/j.jbc.2023.102877. PMID: 36621628.
④Komaki S, Nagata M, Arai E, Otomo R, Ono K, Abe Y, Ohmomo H, Umekage S, Shinozaki O-N, Hachiya T, Sutoh
Y, Otsuka-Yamasaki Y, Arai Y, Hirose N, Yoneyama A, Okano H, Sasaki M, Kanai Y, Shimizu A. Epigenetic profile ofJapanese supercentenarians: a cross-sectional study. Lancet Healthy Longev. 2:e83 (2023).
①Park CJ, Minabe S, Hess RA, Lin PP, Zhou S, Bashir ST, Barakat R,Gal A, and Ko CJ. (2023) Single neonatalestrogen implant sterilizes female animals by decreasing hypothalamic KISS1 expression. Sci Rep. 13:9627.
②Minabe S, Iwata K, Watanabe Y, Ishii H, and Ozawa H. (2022) Long-term effects of prenatal undernutrition on

いわて東北楠詩織

メディカル・メガバンク機構

生殖内分泌学特命助教

博士（農学）

神経内分泌学
繁殖生物学

female rat hypothalamic KNDy neurons. Endocr Connect. 12, e220307.
③Komaki S, Ohmomo H, Hachiya T, Sutoh Y, Ono K, Furukawa R, Umekage S, Otsuka-Yamasaki Y, Minabe S,Takashima A, Tanno K, Sasaki M, and Shimizu A. (2022) Evaluation of short-term epigenetic age fluctuation. Clin
Epigenetics. 14:76.
④Minabe S, Iwata K, Tsuchida H, Tsukamura H, and Ozawa H. (2021) Effect of diet-induced obesity on
Kiss1/Tac3/Pdyn gene expressions in the arcuate nucleus and luteinizing hormone secretion in sex hormoneprimed male and female rats. Peptides, 170546.