Publication List
2006
76. Nadano, R.; Iwai, Y.; Mori, T.; Ichikawa, J. “Divergent Chemical Synthesis of Prolines
Bearing Fluorinated One-Carbon Units at the 4-Position via Nucleophilic 5-Endo-Trig
Cyclizations”, J. Org. Chem. 2006, 71, 8748–8754.
75. Ichikawa,J.;

Nadano,

R.;

Ito,

N.

“5-endoHeck-Type

Cyclizationof

2-(Trifluoromethyl)allyl Ketone Oximes: Synthesis of 4-Difluoromethylene-Substituted
1-Pyrrolines”, Chem. Commun. 2006, 4425–4427.
74. Ichikawa, J.; Nadano, R.; Mori, T.; Wada, Y. “5-Endo-trig Cyclization of
1,1-Difluoro-1-alkenes:

Synthesisof

3-Butyl-2-fluoro-1-tosylindole(1H-Indole,

3-butyl-2-fluoro-1-[(4-methylphenyl)sulfonyl]-) ”, Org. Synth. 2006, 83, 111–120.
73. Saitoh, T.; Yoshida, S.; Ichikawa, J. “Naphthalene-1,8-diylbis(diphenylmethylium) asan Organic Two-Electron Oxidant: Benzidine Synthesis via Oxidative Self-Coupling of
N,N-Dialkylanilines”, J. Org. Chem. 2006, 71, 6414–6419.
72. Ichikawa, J.; Kaneko, M.; Yokota, M.; Itonaga, M. Yokoyama, T. “Friedel–Crafts-Type
Cyclization of 2,2-Difluorovinyl Ketones via α-Fluorocarbocations and Its Applicationin Domino Cyclizations”, Org. Lett. 2006, 8, 3167–3170.
71. Ichikawa, J.; Sakoda, K.; Moriyama, H.; Wada, Y. “Syntheses of Ring-FluorinatedIsoquinolines and Quinolines via Intramolecular Substitution: Cyclization of
1,1-Difluoro-1-alkenes Bearing a Sulfonamide Moiety”, Synthesis 2006, 2006, 1590–
1598.
70. Ichikawa, J.; Sakoda, K.; Mihara, J.; Ito, N. “Heck-Type 5-endo-trig Cyclizations
Promoted by Vinylic Fluorines: Ring-Fluorinated Indene and 3H-Pyrrole Syntheses
from 1,1-Difluoro-1-alkenes”, J. Fluorine Chem. 2006, 127, 489–504.
69. Nadano, R.; Ichikawa, J. “1-(Trifluoromethyl)vinylation via Oxirane or Oxetane Ring
Opening:A

FacileSynthesis

of

4-

or

5-Hydroxy-Functionalized

2-Trifluoromethyl-1-alkenes”, Synthesis 2006, 2006, 128–132.

2005
68. Sakoda, K.; Mihara, J.; Ichikawa, J. “Heck-Type 5-endo-trig Cyclization Promoted by
Vinylic Fluorines: Synthesis of 5-Fluoro-3H-Pyrroles”, Chem. Commun. 2005, 4684–
4686.
(“Synthesis of Fluoropyrroles” Synfacts 2005, 3, 292.)

67. Saitoh, T.; Ichikawa, J. “Bis(triarylmethylium)-Mediated Diaryl Ether Synthesis:
Oxidative Arylation of Phenols with N,N-Dialkyl-4-phenylthioanilines”, J. Am. Chem.
Soc. 2005, 127, 9696–9697.
66. Mori,

T.;

Iwai,

Y.;

Ichikawa,

J.

“Cyclizationofo-Functionalized

α-Trifluoromethylstyrenes: Synthesis of Isoquinoline Derivatives Bearing Fluorinated
One-Carbon Units”, Chem. Lett. 2005, 34, 778–779.
65. Ichikawa, J.; Jyono, H.; Kudo, T.; Fujiwara, M.; Yokota, M. “Friedel–Crafts
Cyclization of 1,1-Difluoroalk-1-enes: Synthesis of Benzene-Fused Cyclic Ketones via

α-Fluorocarbocations”, Synthesis 2005, 2005, 39–46.

2004
64. Saitoh, T.; Yoshida, S.; Ichikawa, J. “1,8-Bis(diphenylmethylium)naphthalenediyl
Dication as an Organic Oxidant: Synthesis of Benzidines via Self-Coupling of
N,N-Dialkylanilines”, Org. Lett. 2004, 6, 4563–4565.
63. Ichikawa, J.; Mori, T.; Iwai, Y “A New Class of Substrates for the Nucleophilic
5-endo-trig Cyclization, 1-Trifluoromethylvinyl Compounds: Syntheses of Indoline andPyrrolidine Derivatives”, Chem. Lett. 2004, 33, 1354–1355.
62. Mori, T.; Ichikawa, J. “4-Difluoromethylated Quinoline Synthesis via IntramolecularSN2ʹ′ Reaction of α-Trifluoromethylstyrenes Bearing Imine Moieties”, Chem. Lett. 2004,
33, 1206–1207.
61. Saitoh, T.; Jimbo, N.; Ichikawa, J. “A Novel Synthesis of syn and anti β-Hydroxy
Dithioacetals, Masked Cross-Aldols between Aldehydes”, Chem. Lett. 2004, 33, 1032–
1033.
60. Ichikawa, J.; Mori, T.; Miyazaki, H.; Wada, Y. “C–C Bond Formation between
Isocyanide and β,β-Difluoroalkene Moieties via Electron Transfer: FluorinatedQuinoline and Biquinoline Syntheses”, Synlett 2004, 2004, 1219–1222.
59. Ichikawa, J.; Miyazaki, H.; Sakoda, K.; Wada, Y. “Ring-Fluorinated Naphthalene andIndene Synthesis via 6- and 5-endo-trig Cyclizations of gem-Difluoroalkenes by Carbon
Nucleophiles”, J. Fluorine Chem. 2004, 125, 585–593.
58. Mori, T.; Ichikawa, J. “KCN-Catalyzed C–C Bond Formation between Imine andgem-Difluoroalkene

Moieties:A

FacileSynthesis

3-Fluoroquinolines”, Chem. Lett. 2004, 33, 590–591.

of

2,4-Disubstituted

2003
57. Wada, Y.; Mori, T.; Ichikawa, J. “A Facile Synthesis of 2,4-Disubstituted
3-Fluoroquinolines

via

Intramolecular

Cyclizationofo-Cyanomethylamino-β,β-difluorostyrenes”, Chem. Lett. 2003, 32, 1000–1001.
56. Ichikawa, J.; Fukui, H.; Ishibashi, Y. “1-Trifluoromethylvinylsilane as a CF2=C––CH2+
Synthon:SynthesisofFunctionalized

1,1-Difluoro-1-alkenes

via

Isolable

2,2-Difluorovinylsilanes”, J. Org. Chem. 2003, 68, 7800–7805.
55. Ichikawa, J.; Wada, Y.; Miyazaki, H.; Mori, T.; Kuroki, H. “Ring-FluorinatedIsoquinoline and Quinoline Synthesis: Intramolecular Cyclization of o-Cyano- ando-Isocyano-β,β-difluorostyrenes”, Org. Lett. 2003, 5, 1455–1458.
54. Ichikawa, J.; Ishibashi, Y.; Fukui, H. “A Novel Synthesis of Functionalized
1,1-Difluoro-1-alkenes via Isolable 2,2-Difluorovinylsilanes”, Tetrahedron Lett. 2003,
44, 707–710.

2002
53. Ichikawa, J.; Saitoh, T.; Tada, T.; Mukaiyama, T. “A Convenient Method for Carbon
Extension of Acetals and Aldehydes by the Use of Ketenedithioacetal andNucleophiles”, Chem. Lett. 2002, 31, 996–997.
52. Ichikawa, J.; Wada, Y.; Fujiwara, M.; Sakoda, K. “The Nucleophilic 5-endo-trig
Cyclization of 1,1-Difluoro-1-alkenes: Ring-Fluorinated Hetero- and Carbocycle
Synthesis and Remarkable Effect of the Vinylic Fluorines on the Disfavored Process”,
Synthesis (Feature Article) 2002, 2002, 1917–1936.
51. Ichikawa,J.;

Sakoda,gem-Difluoroolefins

K.;

with

Wada,
sp3

Y.
Carbon“The

5-endo-trig

CyclizationofNucleophiles:

Synthesisof

1-Fluorocyclopentenes”, Chem. Lett. 2002, 31, 282–283.

2001
50. Ichikawa, J.; Fujiwara, M.; Miyazaki, S.; Ikemoto, M.; Okauchi, T.; Minami, T.
“Regioselective Nucleophilic Additions to Cross-Conjugated Dienone System Bearing
β-Fluorine: A Versatile Approach to Highly Substituted 2-Cyclopentenones”, Org. Lett.
2001, 3, 2345–2348.
49. Wada, Y.; Ichikawa, J.; Katsume, T.; Nohiro, T.; Okauchi, T.; Minami, T.
“Intramolecular Cyclizations of o-Substituted β,β-Difluorostyrenes: Synthesis of

3-Fluorinated Isochromenes and Isothiochromenes”, Bull. Chem. Soc. Jpn. 2001, 74,
971–977.

2000
48. Ichikawa, J. “Ring Constructions by the Use of Fluorine Substituent as Activator andController”, Pure Appl. Chem. 2000, 72, 1685–1689.
47. Ichikawa, J.; Fujiwara, M.; Wada, Y.; Okauchi, T.; Minami, T. “The Nucleophilic
5-endo-trig Cyclization of gem-Difluoroolefins with Homoallylic Functional Groups:
Syntheses of Ring-Fluorinated Dihydroheteroaromatics”, Chem. Commun. 2000, 1887–
1888.
46. Ichikawa, J. “gem-Difluoroolefin Synthesis: General Methods via Thermostable
Difluorovinylmetals Starting from 2,2,2-Trifluoroethanol Derivatives”, J. Fluorine
Chem. 2000, 105, 257–263.
45. Fujiki, K.; Ichikawa, J.; Kobayashi, H.; Sonoda, A.; Sonoda, T. “Syntheses of
Lipophilic Tetraarylborate Ions Substituted with Many Perfluoroalkyl Groups and Their
Stability under Acid Conditions”, J. Fluorine Chem. 2000, 102, 293–300.
44. Okauchi, T.; Nagamori, H.; Kouno, R.; Ichikawa, J.; Minami, T. “Synthesis of
5-Diphenylphosphinoyl-2,3-dihydropyran-4-ones”, Heterocycles 2000, 52, 1393–1398.

1999
43. Minami, T.; Kouno, R.; Okauchi, T.; Nakamura, M.; Ichikawa, J. “Synthetic Utilizationof α-Phosphonovinyl Anions”, Phosphorus, Sulfur and Silicon 1999, 144–146, 689–
692.
42. Hori, K.; Fukuda, S.; Ichikawa, J. “Ab Initio Molecular Orbital Study on Three Feasible
Mechanisms for Substitution on the Vinylic Carbon in F2C=C(OMs)BMe3–”,Tetrahedron 1999, 55, 14915–14924.
41. Hori, K.; Fukuda, S.; Kawano, Y.; Ichikawa, J. “Ab Initio Molecular Orbital Study of
Substitution on the Vinylic Carbon in F2C=C(OMs)BMe3– under SN1-like Mechanism”,
JCPE J. 1999, 11, 23–28.
40. Fujiwara, M.; Ichikawa, J.; Okauchi, T.; Minami, T. “Vinylic C–F Bond Activation
with Low-Valent Zirconocene: the Generation and Cross-Coupling Reactions of
1-Fluorovinylzirconocene”, Tetrahedron Lett. 1999, 40, 7261–7265.
39. Okauchi, T.; Yano, T.; Fukamachi, T.; Ichikawa, J.; Minami, T. “α–Phosphonovinyl

Nonaflate: Their Synthesis and Cross-Coupling Reactions”, Tetrahedron Lett. 1999, 40,
5337–5340.
38. Ichikawa, J.; Jyono, H.; Yonemaru, S.; Okauchi, T.; Minami, T. “A Facile Synthesis of
1-H-2,2-Difluorovinylphosphorus

Compoundsfrom

2,2,2-Trifluoroethyl

Trifluoromethanesulfonate and Substitutions of Their Vinylic Fluorines”, J. Fluorine
Chem. 1999, 97, 109–114.

1998
37. Kouno, R.; Okauchi, T.; Nakamura, M.; Ichikawa, J.; Minami, T. “Synthesis andSynthetic Utilization of α-Functionalized Vinylphosphonates Bearing β-Oxy or β-Thio
Substituents”, J. Org. Chem. 1998, 63, 6239–6246.
36. Ichikawa, J.; Fujiwara, M.; Okauchi, T.; Minami, T. “Fluorine-Directed Nazarov
Cyclizations 2: Regioselective Synthesis of 5-Trifluoromethyl-2-cyclopentenones”,
Synlett 1998, 1998, 927–929.

1997
35. Okauchi, T.; Kakiuchi, T.; Kitamura, N.; Utsunomiya, T.; Ichikawa, J.; Minami, T.
“Lewis Acid-Catalyzed Intramolecular [2+2] Cycloaddition of α-Ester-Substituted
Conjugated Dienyl- and Trienylphosphonates.

New Synthesis of Functionalized

Cyclic Terpenoids”, J. Org. Chem. 1997, 62, 8419–8424.
34.

Okauchi,T.;

Fukamachi,

T.;

Nakamura,“2-Phosphono-1,1,4,4,-tetrathio-1,3-butadienes.

F.;

Ichikawa,

J.;

Minami,T.

Synthesis and Synthetic Application

to Highly Functionalized Dienes and Heterocycles”, Bull. Soc. Chim. Belg. 1997, 106,525–532.
33. Ichikawa, J.; Wada, Y.; Okauchi, T.; Minami, T. “5-endo-Trigonal Cyclization of

ο-Substituted

gem-Difluorostyrenes:

Synthesesof

2-FluorinatedIndoles,

Benzo[b]furans, and Benzo[b]thiophenes”, Chem. Commun. 1997, 1537–1538.

1996
32. Minami, T.; Okauchi, T.; Matsuki, H.; Nakamura, M.; Ichikawa, J.; Ishida, M.
“Synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis
of Dithioallenes and (α-Dithiocarboxyvinyl)phosphonates”, J. Org. Chem. 1996, 61,
8132–8140.

31. Ichikawa, J.; Fujiwara, M.; Nawata, H.; Okauchi, T.; Minami, T. “Novel
2,2-Difluorovinylzirconocene:A

FacileSynthesisofMonosubstituted

gem-Difluoroolefins via Its Cross-Coupling Reaction”, Tetrahedron Lett. 1996, 37,
8799–8802.
30. Ichikawa, J.; Kobayashi, M.; Noda, Y.; Yokota, N.; Amano, K.; Minami, T.
“Regiocontrolled Syntheses of 3- or 5-Fluorinated Pyrazoles from 2,2-Difluorovinyl
Ketones”, J. Org. Chem. 1996, 61, 2763–2769.
29. Ichikawa, J.; Yokota, N.; Kobayashi, M.; Amano, K.; Minami, T. “The Reaction of
2,2-Difluorovinyl Ketones with Amines:

A Facile Method for Preparation of

α-Oxoketenimines and Acetoacetylation of Amines”, Synlett 1996, 1996, 243–245.

1995
28. Okada, Y.; Minami, T.; Miyamoto, M.; Otaguro, T.; Sawasaki, S.; Ichikawa, J.
“Construction of α-Phosphonolactams via Rhodium (II)-Catalyzed Intramolecular C–H
Insertion Reactions”, Heteroatom Chem. 1995, 6, 195–210.
27. Ichikawa, J.; Miyazaki, S.; Fujiwara, M.; Minami, T. “Fluorine-Directed Nazarov
Cyclizations:

A Controlled Synthesis of Cross-Conjugated 2-Cyclopenten-1-ones”, J.

Org. Chem. 1995, 60, 2320–2321.

1994
26. Minami, T.; Utsunomiya, T.; Nakamura, S.; Okubo, M.; Kitamura, N.; Okada, Y.;
Ichikawa, J. “Intramolecular Ene Reaction of Vinylphosphonates. Synthetic Application
to Bicyclic Compounds and Cadalane and Valerenic Acid Terpenoids”, J. Org. Chem.
1994, 59, 6717–6727.
25. Ichikawa, J.; Kobayashi, M.; Yokota, N.; Noda, Y.; Minami, T. “Reaction of
2,2-Difluorovinyl Ketones with Heteroatom Nucleophiles: A General One-Pot
Synthesis of α-Oxoketene Acetals”, Tetrahedron 1994, 50, 11637–11646.

1993
24. Okada, Y.; Minami, T.; Ichikawa, J. “A Novel Type of Chiral Diphosphine Ligand,trans-2,3-Bis(diphenylphosphino)-1-methyl-1-cyclopropanecarboxylic

Acid

and

Asymmetric Allylic Alkylation by the Use of Its Palladium Complex”, Phosphorus,
Sulfur, and Silicon 1993, 77, 153.

23. Minami, T.; Isonaka, T.; Okada, Y.; Ichikawa, J. “Copper(I) Salt-Mediated Arylation of
Phosphinyl-Stabilized

Carbanions

andSynthetic

Application

to

Heterocyclic

Compounds”, J. Org. Chem. 1993, 58, 7009–7015.
22. Minami, T.; Kamitamari, M.; Utsunomiya, T.; Tanaka, T.; Ichikawa, J. “Synthesis ofAnnulated γ-Lactams via Intramolecular 1,3-Dipolar Cycloadditions of Functionalized
N-Allyl α-Diazo Amides”, Bull. Chem. Soc. Jpn. 1993, 66, 1496–1500.
21. Ichikawa, J.; Ikeura, C.; Minami, T. “A One-Pot Synthesis of Conjugated Fluoroenynes
via 2,2-Difluorovinylcopper Intermediates”, J. Fluorine Chem. 1993, 63, 281–285.
20. Ichikawa, J.; Yokota, N.; Kobayashi, M.; Minami, T. “The Reaction of Fluorovinyl
Ketones with Carbon Nucleophiles: A New General Route to α,β-Unsaturated Ketones”,
Synlett 1993, 1993, 186–188.

1992
19. Ichikawa, J.; Yonemaru, S.; Minami, T. “A Novel Synthesis of 2,2-Difluorovinyl- and2-Fluorovinylphosphorus Compounds from 2,2,2-Trifluoroethyl p-Toluenesulfonate”,
Synlett 1992, 1992, 833–834.
18. Ichikawa, J.; Ikeura, C.; Minami, T. “A New Synthesis of 1,1-Difluoro-1,3-dienes via
the Coupling Reaction of 2,2-Difluoro-vinylboranes”, Synlett 1992, 1992, 739–740.

17. Fujiki, K.; Kashiwagi, M.; Miyamoto, H.; Sonoda, A.; Ichikawa, J.; Kobayashi, H.;
Sonoda, T. “Syntheses and Lipophilicities of Tetraarylborate Ions Substituted with
Many Trifluoromethyl Groups”, J. Fluorine Chem. 1992, 57, 307–321.
16. Ichikawa, J.; Minami, T.; Sonoda, T.; Kobayashi, H. “A Facile Synthesis of
Disubstituted

1,1-Difluoro-1-alkenes

via

DoubleTransmetalationof

2,2-Difluorovinylboranes”, Tetrahedron Lett. 1992, 33, 3779–3782.
15. Okada, Y.; Minami, T.; Yamamoto, T.; Ichikawa, J. “A Novel Type of Chiral
Diphosphinetrans-2,3-Bis(diphenylphosphino)-1-methyl-1-cyclopropanecarboxylic

Ligand,AcidandAsymmetric Allylic Alkylation by the Use of Its Palladium Complex”, Chem. Lett.
1992, 21, 547–550.
14. Ichikawa, J.; Hamada, S.; Sonoda, T.; Kobayashi, H. “A One-Pot Synthesis of
2,2-Difluorovinyl Carbonyl Compounds from 2,2,2-Trifluoroethyl p-Toluenesulfonate
via 2,2-Difluorovinylboranes”, Tetrahedron Lett. 1992, 33, 337–340.

1991
13. Ichikawa, J.; Moriya, T.; Sonoda, T.; Kobayashi, H. “A Novel Synthesis of
Disubstituted 1,1-Difluoro-1-alkenes by Using 2,2,2-Trifluoroethyl p-Toluenesulfonate
as a Difluorovinylidene Unit”, Chem. Lett. 1991, 20, 961–964.

1989
12. Ichikawa, J.; Sonoda, T.; Kobayashi, H. “Reactions of 2,2-Difluoroalkenylboranes with
Halogens in the Presence of Base. Novel Syntheses of Symmetrically Disubstituted
1,1-Difluoro-1-alkenes and 1,1-Difluoro-2-iodo-1-alkenes”, Tetrahedron Lett. 1989, 30,
6379–6382.
11. Ichikawa, J.; Sonoda, T.; Kobayashi, H. “A Novel Synthesis of Difluoromethyl Ketones
from

2,2,2-Trifluoroethylp-Toluenesulfonate

via

2,2-Difluoroalkenylboranes”,

Tetrahedron Lett. 1989, 30, 5437–5438.
10. Ichikawa, J.; Sonoda, T.; Kobayashi, H. “A Novel Synthesis of 1,1-Difluoroolefinsfrom 1,1,1-Trifluoroethyl p-Toluenesulfonate via Boron Ate-Complex”, Tetrahedron
Lett. 1989, 30, 1641–1644.

1988
9.

Ichikawa, J.; Sonoda, T.; Kobayashi, H. “Radical Transport Reaction. Concurrent
Transfer of Electron and Proton”, Bull. Chem. Soc. Jpn. 1988, 61, 2923–2926.

1987
8.

Ichikawa, J.; Sugimoto, K.; Sonoda, T.; Kobayashi, H. “A Facile Method for the
Fluorine Substitution of Phenylthio Group via Sulfonium Salts Using Cesium Fluoride”,
Chem. Lett. 1987, 16, 1985–1988.

1986
7.

Mukaiyama, T.; Hayashi, M.; Ichikawa, J. “A Stereocontrolled Synthesis of
2,3,5-Trisubstituted Tetrahydrofurans from Aldolized γ-Diketones via Cyclization–
reduction Process”, Chem. Lett. 1986, 15, 1157–1160.

1985
6.

Mukaiyama, T.; Ichikawa, J.; Toba, M.; Hayashi, M. “A Regio- and Stereoselective

Synthesis of Aldolized γ-Diketones via Tin(IV) Bisenolates by the Use ofBis(2-pyridinethiolato)tin(II) ”, Chem. Lett. 1985, 14, 1539–1542.
5.

Ichikawa J.; Mukaiyama, T. “A Facile Synthesis of α,β-Dihydroxyketones via Tin(IV)Enediolates by Utilizing the Reducing Power of Bis(2-pyridinethiolato)tin(II)”, Chem.
Lett. 1985, 14, 1009–1012.

1984
4.

Ichikawa, J.; Asami, M.; Mukaiyama, T. “An Asymmetric Synthesis of Glycerol
Derivatives by the Enantioselective Acylation of Prochiral Glycerol”, Chem. Lett. 1984,
13, 949–952.

1983
3.

Mukaiyama, T.; Ichikawa, J.; Toba, M.; Asami, M. “A Novel Method for the One-step
Synthesis of N-Alkyl Imides by the Use of 1,1'-Dimethyl-stannocene”, Chem. Lett.
1983, 12, 879–880.

2.

Mukaiyama, T.; Ichikawa, J.; Asami, M. “A Facile Synthesis of Carboxylic Esters andCarboxamides by the Use of 1,1'-Dimethylstannocene as a Condensing Reagent”, Chem.
Lett. 1983, 12, 683–686.

1.

Mukaiyama, T.; Ichikawa, J.; Asami, M. “Facile Method for the Acylation of Alcohols
and Amides by the Use of 1,1-Dimethylstannocene and Acyl Chlorides”, Chem. Lett.
1983, 12, 293–296.