脳神経外科学講座

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主な論文・著作・業績①Tsutsui S, Matsuda T, Takeda K, Sasaki M, Kubo Y, Setta K, Fujiwara S, Chida K, Ogasawara K.. Assessment of
Heating on Titanium Alloy Cerebral Aneurysm Clips during 7T MRI. AJNR Am J Neuroradiol. 2022 Jul;43(7):972-977.
② Ogasawara K, Uchida S, Akamatsu Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Kubo Y.
Outcomes of Medical Management Alone for Adult Patients with Cerebral Misery Perfusion Due to Ischemic
Moyamoya Disease. J Stroke Cerebrovasc Dis. 2022 Aug;31(8):106588. doi:
10.1016/j.jstrokecerebrovasdis.2022.106588.
③ Yasuda S, Katakura Y, Kubo Y, Dobashi K, Kimura K, Fujiwara S, Chida K, Akamatsu Y, Kobayashi M, Yoshida K,
Terasaki K, Ogasawara K. Recovery of Cortical Neurotransmitter Receptor Function and Its Impact on Cognitive
Improvement after Indirect Revascularization Surgery Alone for Adult Patients with Ischemic Moyamoya Disease:

小笠原

邦昭

脳神経外科学講座

教授

博士（医学）

脳神経外科学

123I-Iomazenil Single-Photon Emission Computed Tomography Study. World Neurosurg. 2022 Aug;164:e1135e1142.
④Miyamoto S, Ogasawara K, Kuroda S, Itabashi R, Toyoda K, Itoh Y, Iguchi Y, Shiokawa Y, Takagi Y, Ohtsuki T,
Kinouchi H, Okada Y, Takahashi JC, Nakase H, Kakuda W.
Japan Stroke Society Guideline 2021 for the Treatment of Stroke. Int J Stroke. 2022 Apr 20:17474930221090347.
doi: 10.1177/17474930221090347. .
⑤ Kimura K, Kubo Y, Dobashi K, Katakura Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Kawamura
T, Ogasawara K. Angiographic, Cerebral Hemodynamic, and Cognitive Outcomes of Indirect Revascularization
Surgery Alone for Adult Patients With Misery Perfusion due to Ischemic Moyamoya Disease. Neurosurgery. 2022
Jun 1;90(6):676-683.

①Beppu T, Iwaya T, Sato Y, Nomura J, Terasaki K, Sasaki T, Yamada N, Fujiwara S, Sugai T, Ogasawara K. Positronemission tomography with 11C-methyl-L-methionine as a predictor of consequential outcomes at the time of
discontinuing temozolomide-adjuvant chemotherapy in patients with residual IDH-mutant lower-grade glioma. Clin
Nucl Med 47:569-574, 2022
②Beppu T, Sato Y, Yamada , Terasaki K, Sasaki T, Sugai T, Ogasawara K. Impacts on histological features and 11Cmethyl-L-methionine uptake after “one-shot” administration with bevacizumab before surgery in newly diagnosed
glioblastoma. Transl Oncol 12: 1480-87, 2019別府高明

脳神経外科学講座

教授

博士（医学）

脳神経外科学③Beppu T, Sato Y, Sasaki T, Terasaki K, Yamashita F, Sasaki M, Ogasawara K. 1 Comparisons between positronemission tomography with 11C-methyl-L-methionine and arterial spin labeling perfusion imaging in recurrent
glioblastomas treated with bevacizumab. Clin Nucl Med

44(3):186-193、2019.

④Beppu T, Sasaki T, Sato Y, Terasaki K. High-uptake areas on 18F-FRP170 PET image necessarily include
proliferating areas in glioblastoma: A

superimposed image study combining 18F-FRP170 PET with 11C-

mehionine PET. Adv Mol Imaging 7: 1-11, 2017; DOI: 10.4236/ami.2017.71001⑤文部科学省科学研究費補助金「課題名：膠芽腫におけるグリオーマ幹細胞の高分布領域の同定に関する研究」20202022年

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主な論文・著作・業績①Kubo Y, Koji T, Fujiwara S, Chida K, Akamatsu Y, Kashimura H, Ogasawara K. Long-term outcomes, including thesurvival rate and period to death, in patients over 80 years old after ruptured cerebral aneurysm clipping. J Stroke
Cerebrovasc Dis. 2022 Aug 3;31(9):106691.
②Kubo Y, Koji T,Murakami T,Yoshida K,Matsumoto M, Ogasawara K, Long-term outcomes of cerebral blood flow
and neurotransmitter receptor function on 123 I-iomazenil SPECT and of cognitive assessments after parent artery
occlusion combined with cerebral revascularization for internal carotid artery aneurysms. World Neurosurg.,
S1878-8750, 31640-5, 2020
③Kubo Y, Koji T,Kodo R,Yoshida K,Ogasawara K.Intraoperative monitoring of cerebral cortical blood flow and久保慶高

脳神経外科学講座准教授

博士（医学）

脳神経外科学

middle cerebral artery pressure as a substitute for preoperative balloon test occlusion in patients with internal
carotid artery aneurysms.Acta Neurochir(Wien)160:1129-1137,2018④Kubo Y, Koji T,Kashimura H, Otawara Y, Ogawa A, Ogasawara K.Female sex as a risk factor for the growth ofasymptomatic unruptured cerebral saccular aneurysms in elderly patients. J Neurosurg 27: 1-6,2014⑤Kubo Y, Koji T,Kashimura H, Otawara Y, Ogawa A, Ogasawara K. Appetite loss may be induced by lower serum
ghrelin and higher serum leptin concentrations in subarachnoid hemorrhage patients.Nutr Neurosci.17: 230-233,
2014⑥Kubo Y, Koji T,Yoshida J, Ogawa A, Ogasawara K.Predicting neurological deficit severity due to subarachnoid
haemorrhage: soluble CD40 ligand and platelet-derived growth factor-BB.Crit Care Resusc.18: 242-246, 2016
①Yoshida K, Ogasawara K, Kobayashi M, Tsuboi J, Okabayashi H, Ogawa A.

Scar formation in the carotid sheath

identified during carotid endarterectomy in patients with previous cardiac surgery: significance of history oftraoperative Swan-Ganz catheter insertion.

J Neurosurg. 2010 Oct;113(4):885-9.

②Yoshida K, Nishida W, Hayashi K, Ohkawa Y, Ogawa A, Aoki J, Arai H, Sobue K. Vascular remodeling induced bynaturally occurring unsaturated lysophosphatidic acid in vivo. Circulation. 2003 Oct 7;108(14):1746-52.

吉田研二

脳神経外科学講座

特任准教授

博士（医学）

脳神経外科学③Hayashi K, Takahashi M, Nishida W, Yoshida K, Ohkawa Y, Kitabatake A, Aoki J, Arai H, Sobue K. Phenotypic
modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ Res. 2001 Aug
3;89(3):251-8.
④文部科学省科学研究費補助金 基盤研究（C）「課題名：一過性脳虚血及び再灌流時のレドックス解析に基づいた新たな脳循環代謝障害指標の確立」2012-2014年⑤文部科学省科学研究費補助金 基盤研究（C）「課題名：脳虚血再灌流時の内頚静脈血中血管ホルモン動態解析による
脳血流自動調節機構の解明」2018-2020年

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主な論文・著作・業績①Nishikawa Y, Kobayashi K, Oshima H, Fukaya C, Yamamoto T, Katayama Y, Ogawa A, Ogasawara K. :Direct reliefof levodopa-induced dyskinesia by stimulation in the area above the subthalamic nucleus in a patient with
Parkinson's disease--case report./Neurol Med Chir. 50(3):257-9(2010)②Nishikawa Y, Doi M, Koji T, Watanabe M, Kimura S, Kawasaki S, Ogawa A, Sasaki K.:The role of rho and rhodependent kinase in serotonin-induced contraction observed in bovine middle cerebral artery./Tohoku J Exp西川泰正

脳神経外科学講座

講師

博士（医学）

脳神経外科学Med.201(4):239-49(2003)③Nishikawa Y, Suzuki M, Kuwata N, Ogawa A. :Microvascular decompression for treating glossopharyngeal
neuralgia complicated by sick sinus syndrome./Acta Neurochir.142(3):351-2(2000)④西川 泰正、小笠原 邦昭 各種神経障害性痛の現状と可能性 １）脳卒中後痛に対するニューロモデュレーション
治療の現状/ペインクリニック

33（7）930-938（2012）⑤文部科学省科学研究費補助金 基盤研究（C）「課題名：受容体PET画像radiomics解析によるDBS術後統合失調症的
精神症状の予知」2022-2024年）①Sugawara A, Isu T, Kim K, Matsumoto R, Isobe M, Ogasawara K: Sylingomyelia associated with Chiari I
Malformation treated with foramen magnum decompression and duraplasty using a polyglycolic acid patch andfibrin Glue –A case report –J Nippon Med Sch 77: 2010(in press)②Kuroda H, Sugawara A, Ogsawara K, Ogawa A: Idiopathic spinal cord herniation surgery causing Brown-Sequard
syndrome: A case report. Jpn J Neurosurg 19: 557-561, 2010
③Sugawara A, Isu T, Kim K, Morimoto D, Isobe M, Matsumoto R, Ogasawara K, Ogawa A: Mid-term results of菅原淳

脳神経外科学講座

講師

博士（医学）

脳神経外科学

posterior decompression for spinal stenosis due to degenerative lumbar spondylolisthesis. Spinal Surgery 23: 225230, 2009
④Sugawara A, Kim K, Isobe M, Matsumoto R, Isu T: Surgical treatment of spinal lipoma without spina bifida atlumbar region –Three case reports-. Neurol Med Chir [Tokyo] 49:616-618, 2009
⑤Kim K, Isu T, Sugawara A, Morimoto D, Matsumoto R, Isobe M, Mishina M, Kobayashi S, Teramoto A:
Radiological study of the sandwich method in cervical anterior fusion using autologous vertebral bone grafts. J
Clini Neurosci 17: 450-454, 2009

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主な論文・著作・業績①Kobayashi M, Igarashi S, Takahashi T, et al Optimal timing for measuring cerebral blood flow after acetazolamide
administration to detect preexisting cerebral hemodynamics and metabolism in patients with bilateral major
cerebral artery steno-occlusive diseases: 15O positron emission tomography studies. Am J Nucl Med Mol Imaging.
11(6):507-518, 2021.
②Kobayashi M, Yoshida K, Kojima D, et al Impact of external carotid artery occlusion at declamping of theexternal and common carotid arteries during carotid endarterectomy on development of new postoperative
ischemic cerebral lesions. J.vasc surg.69(2):454-461, 2019.

小林正和

脳神経外科学講座

講師

博士（医学）

脳神経外科学③2004年-2005年文部科学省科学研究費補助金若手B PETを用いた慢性脳虚血における経時的acetazolamide反応性に関する研究④2012年-2014年文部科学省科学研究費補助金基盤C 脳主幹動脈閉塞性病変による貧困灌流の新たな非侵襲的画像診断法の開発と臨床応用⑤2016年-2018年文部科学省科学研究費補助金基盤C 超高磁場MRIによる数値流体解析とプラーク画像を用いた頚動脈
術中塞栓発生の解明⑥2021年-2023年文部科学省科学研究費補助金基盤C 脳梗塞慢性期における血行再建術後のアミロイド排出と大脳白質
微細構造変化の関係①幸治孝裕、小笠原邦昭.：未破裂脳動脈瘤 / 神経最新の治療2018-2020. 102-104 (2018).
②幸治孝裕、久保慶高、小笠原邦昭．:subtemporal approach / プライム脳神経外科1 脳動脈瘤. 129-133 (2017).
③Kubo Y, Koji T,Kodo R,Yoshida K,Ogasawara K. Intraoperative monitoring of cerebral cortical blood flow andmiddle cerebral artery pressure as a substitute for preoperative balloon test occlusion in patients with internal

幸治

孝裕

脳神経外科学講座

特任講師

博士（医学）

脳神経外科学

carotid artery aneurysms. Acta Neurochir(Wien)160:1129-1137, 2018
④Koji T., Kubo Y., Matsumoto Y., Akamatsu Y., Chida K, Kashimura H., Ogasawara K. Intracranial hemorrhage
associated with direct oral anticoagulant after clipping for an unruptured cerebral aneurysm: A report of twocases. Surgical Neurology International 13: 1-5. 2022
⑤文部科学省科学研究費補助金 基盤C 「課題名：高解像度7T-MRIによる未破裂脳動脈瘤壁厚評価法の確立」 2020年-2023年①Kimura K, Kubo Y, Dobashi K, Katakura Y, Chida K, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K, Kawamura
T, Ogasawara K. Angiographic, Cerebral Hemodynamic, and Cognitive Outcomes of Indirect Revascularization
Surgery Alone for Adult Patients With Misery Perfusion due to Ischemic Moyamoya Disease. Neurosurgery.
2022;90:676-683.
②Fujiwara S, Mori Y, de la Mora DM, Akamatsu Y, Yoshida K, Shibata Y, Masuda T, Ogasawara K, Yoshioka Y.
Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in

博士

藤原

俊朗

脳神経外科学講座

助教（ソフトウェア情報 医用工学、脳神経学）
博士（医学）

科学、MRI

common carotid artery occlusion rats. Sci Rep. 2020;10:8404.
③Fujiwara S, Sato S, Sugawara A, Nishikawa Y, Koji T, Nishimura Y, Ogasawara K. The Coefficient of Variation of
Step Time Can Overestimate Gait Abnormality: Test-Retest Reliability of Gait-Related Parameters Obtained with a
Tri-Axial Accelerometer in Healthy Subjects. Sensors (Basel). 2020;20.pii: E577.
④文部科学省科学研究費補助金 基盤研究（C)「課題名：大脳水拡散現象を基軸とした新たな完全無侵襲病態診断法の開発」2019年 -2022年（代表）⑤文部科学省科学研究費補助金 基盤研究（C)「受容体PET画像radiomics解析によるDBS術後統合失調症的精神症状の予知」2022年 -2024年（分担）脳神経外科学講座

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主な論文・著作・業績①Chida K, Shimada Y, Fujimoto K, Yoshida J, Kojima D, Fujiwara S, Kobayashi M, Yoshida K, Sasaki M, Ogasawara
K: Identification of the distal end of carotid plaque using 3-dimensional fast spin echo T1-weighted magnetic
resonance plaque imaging. J Stroke Cerebrovasc Dis 29:104680(2020)②Chida K, Ogasawara K, Kuroda H, Aso K, Kobayashi M, Fujiwara S, Yoshida K, Terasaki K, Ogawa A: Central
benzodiazepine receptor binding potential and CBF images on SPECT correlate with oxygen extraction fraction
images on PET in the cerebral cortex with unilateral major cerebral artery occlusive disease. J Nucl Med 52:5118(2011)③ Chida K, Ogasawara K, Aso K, Suga Y, Kobayashi M, Yoshida K, Terasaki K, Tsushina E, Ogawa A: Postcarotid

千田光平

脳神経外科学講座

助教

博士（医学）

脳神経科学

endarterectomy improvement in cognition is associated with resolution of crossed cerebellar hypoperfusion andincrease in 123I-iomazenil uptake in the cerebral cortex: a SPECT study. Cerebrovasc Dis 29:343-51(2010)④Chida K, Ogasawara K, Suga Y, Saito H, Kobayashi M, Yoshida K, Otawara Y, Ogawa A: Postoperative corticalneural loss associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: 123Iiomazenil SPECT study. Stroke 40:448-53(2009)⑤文部科学省科学研究費補助金 研究スタート支援「課題名：7T超高磁場MRIを用いた新たな無侵襲脳循環代謝評価法の開発とその応用」2015-2016年⑥文部科学省科学研究費補助金 基盤研究（C）「課題名：脳動脈血行再建術後過灌流による認知機能障害の分子生物学的メカニズムの解明」2019-2021年①Sato Y, Wada T, Nishikawa Y, Yoshida K, Kurose A, Ogawa A, Ogasawara K: Growth hormone-producing pituitaryadenoma regrowing as pituitary adenoma with neuronal choristoma 14 years after tumor removal. World
Neurosurg, 80, 436.e11–436.e13, 2013.
②佐藤雄一，吉田研二，小林正和，黒田博紀，鈴木太郎，小川彰，小笠原邦昭: 術中モニタリングと血圧コントロール
下に観血的に根治せしめた症候性頚部内頚動脈起始部血栓化動脈瘤の一例. 脳卒中の外科, 40: 267-272. 2012.
③Yuichi Sato, Akira Kurose, Akira Ogawa, Kuniaki Ogasawara, Frank Traganos, Zbigniew Darzynkiewicz and佐藤雄一

脳神経外科学講座

助教

博士（医学）

脳神経科学

Takashi Sawai: Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53
status to treatment with etoposide and temozolomide. Cancer Biology and Therapy, 8(5): 452-457, 2009.
④Yuichi SATO, Shunsuke KAKINO, Kuniaki OGASAWARA, Yoshitaka KUBO, Hiroki KURODA, and Akira OGAWA：
Rupture of a Concomitant Unruptured Cerebral Aneurysm Within 2 Weeks of Surgical Repair of a Ruptured
Cerebral Aneurysm -Case Report-. Neurologia medico-chirurgica, 48(11): 512-514, 2008.
⑤文部科学省科学研究費補助金 若手研究(B)「課題名：膠芽腫におけるPETを用いた腫瘍幹細胞高密度領域を同定する研究」2016年-2018年

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主な論文・著作・業績① Yoshida J, Akamatsu Y, Kojima D, Miyoshi K, Kashimura H, Kubo Y, Ogasawara K. Endovascular intervention forbilateral paramedian thalamic stroke due to occlusion of the unilateral P1 segment of the posterior cerebral artery:illustrative cases. J Neurosurg Case Lessons. 2022 Jul 04;4(2):CASE22152. doi: 10.3171/CASE22152②Yanagihara W, Akamatsu Y, Shibanai K, Fujimoto K, Kojima D, Kashimura H, Kubo Y, Ogasawara K. Cerebral
protection during retrograde brachiocephalic artery stenting using a single filter and increased subclavian steal
phenomenon: illustrative case. J Neurosurg Case Lessons. 2022 Jul 04;4(1):CASE22194. doi: 10.3171/CASE22194③ Akamatsu Y, Gomez-Paz S, Tonetti DA, Vergara-Garcia D, Moholkar VM, Kuhn AL, Chida K, Singh J, Rodrigues

赤松洋祐

脳神経外科学講座

助教

博士（医学）

脳神経科学

KM, Massari F, Moore JM, Ogilvy CS, Puri AS, Thomas AJ. Middle meningeal artery: An effective pathway forachieving complete obliteration following transarterial Ethylene Vinyl Copolymer (Onyx) embolization of duralarteriovenous fistulas. J Cerebrovasc Endovasc Neurosurg. 2022 Jul 7. doi: 10.7461/jcen.2022.E2021.03.008.
④ Kojima D, Akamatsu Y, Yoshida J, Miyoshi K, Kashimura H, Ogasawara K. Drag-out technique using a large
balloon fixed with an aspiration catheter for retrieving residual thrombus on the wall of the superior sagittal sinus:
illustrative case.J Neurosurg Case Lessons. 2022 May 23;3(21):CASE22116. doi: 10.3171/CASE22116. eCollection
2022 May 23.
⑤文部科学省科学研究費補助金 基盤研究(C)「課題名：既往脳卒中症状再燃に対する感染症の関連と脳拡散テンソル
画像による病変可視化の試み」2020年-2022年①Saura H, Ogasawara K, Beppu T, Yoshida K, Kobayashi M, Yoshida K, Terasaki K, Takai Y, Ogawa A: Hypoxic
viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive
disease. Stroke. 2015;46:1250-1256.
②Saura H, Ogasawara K, Suzuki T, Kuroda H, Yamashita T, Kobayashi M, Terasaki K, Ogawa A. Effect of
combination therapy with the angiotensin receptor blocker losartan plus hydrochlorothiazide on brain perfusion inpatients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major

佐浦宏明

脳神経外科学講座

助教

博士（医学）

脳神経外科学

cerebral artery steno-occlusive disease: a SPECT study. Cerebrovasc Dis.2012;33:354-361.
③Saura H, Kashimura H, Aso K, Matsumoto Y. Fenestrated T-bar clips in the surgical management of internal
carotid artery aneurysms: technical note. World Neurosurg. 2018:117;1-3.
④Saura H, Beppu T, Matsuura H, Asahi S, Uesugi N, Sasaki M, Ogasawara K. Intractable yawning associated withmature teratoma of the supramedial cerebellum: Case report. J Neurosurg. 2014:121;387-389.
⑤文部科学省科学研究費補助金 若手研究「超高磁場拡散強調画像MRIに基づく定量的髄膜腫硬度計測法の開発」
2018-2020年

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主な論文・著作・業績①Nomura JI, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M, Ogasawara K.：
Preoperative Cerebral Oxygen Extraction Fraction Imaging Generated from 7T MR Quantitative Susceptibility
Mapping Predicts Development of Cerebral Hyperperfusion following Carotid Endarterectomy.AJNR Am J
Neuroradiol. 2017 Dec;38(12):2327-2333.
②Nomura JI, Beppu T, Sasaki M, Fujiwara S, Ogasawara K.Detection of Retinal Hemangioblastomas in von HippelLindau Disease Using Three-Dimensional Arterial Spin Labeling MR Imaging at 3T.Magn Reson Med Sci.2017野村順一

脳神経外科学講座

助教

博士（医学）

脳神経外科学16(1):1-2.
③Nomura J, Ogasawara K, Saito H, Terasaki K, Matsumoto Y, Takahashi Y, Ogasawara Y, Saura H, Yoshida K, Sato
Y, Kubo Y, Ogawa A.Neurol Res.2014 (3):262-9.
④ 野村順一，菅原 淳，石垣大哉，藤原俊朗，川崎朋範，小笠原邦昭:腰椎穿刺後に硬膜内くも膜外に発生した類上皮腫の1例.脳神経外科速報,27:297-300. 2017.
⑤Nomura JI, Tsutsui S, Hatchome Y, Misaki T, Konno H, Ogasawara K.Ruptured Aneurysm at the Origin of an
Anomalous Callosomarginal Artery Arising from the A1 Segment of the Anterior Cerebral Artery-A Case Report.
NMC Case Rep J. 2022 21:183-186.