生化学講座

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主な論文・著作・業績①Matsumoto, S., et al. (8th in 8 authors): Receptor tyrosine kinase ligands and inflammatory cytokines
cooperatively suppress the fibrogenic activity in temporomandibular-joint–derived fibroblast-like synoviocytes
through mitogen-activated protein kinase kinase/extracellular signal-regulated kinase. Exp. Ther. Med., 20: 19671974, 2020.
②Takizawa, N., et al. (12th in 13 authors): Bone marrow-derived mesenchymal stem cells propagate

石崎明

生化学講座
細胞情報科学分野

教授

博士（歯学）

常態系口腔科学関連

immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners

病態系口腔科学関連

under hypoxic culture., Exp. Cell Res., 358: 411-420, 2017.

腫瘍生物学関連③Kanno, Y., et al. (2nd in 12 authors): Plasminogen/Plasmin modulates bone metabolism by regulating theosteoblast and osteoclast function.

J. Biol. Chem., 286: 8952-8960, 2011.

④Ishisaki, A., et al. (1st in 4 authors): Human umbilical vein endothelium-derived cells retain potential todifferentiate into smooth muscle-like cells. J. Biol. Chem., 278: 1303-1309, 2003.
⑤Ishisaki, A., et al. (1st in 9 authors): Differential Inhibition of Smad6 and Smad7 on bone morphogenetic proteinand activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem., 274: 13637-13642, 1999.
①Hirano T., et al.(last in 5 authors/Corresponding author): TGF-β1 induces N-cadherin expression byupregulating Sox9 expression and promoting its nuclear translocation in human oral squamous cell carcinoma
cells./ Oncol Lett. 20:474-482(2020)②Hino M., et al. (2nd in 7 authors/Corresponding author): Transforming growth factor-β1 induces invasion abilityof HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis./ J.

加茂政晴

生化学講座
細胞情報科学分野

准教授

博士（理学）

常態系口腔科学関連

Biochem.159:631–640(2016)

病態系口腔科学関連③Saito, D., et al. (last in 9 authors/Corresponding author): Transforming growth factor-β1 induces epithelial-

腫瘍生物学関連

mesenchymal transition and integrin α3β1-mediated cell migration of HSC-4 human squamous cell carcinoma
cells through Slug./ J. Biochem. 153:303–315(2013)④Kamo, M. and Tsugita, A.: Specific cleavage of amino side chains of serine/threonine in peptides and proteins
with S-ethyl trifluorothioacetate vapor./ Eur. J. Biochem. 255:162-171(1998)⑤Kamo, M., et al.(1st in 4 authors): Separation and Characterization of Arabidopsis thathiana proteins by twodimensional gel electrophoresis./ Electrophoresis 16:423-430(1995)①Chosa N., Ishisaki A. "Two novel mechanisms for maintenance of stemness in mesenchymal stem cells:
SCRG1/BST1 axis and cell-cell adhesion through N-cadherin". Japanese Dental Science Review, 54:37-44, 2018.
②Suzuki K.*, Chosa N.*, Sawada S., Takizawa N., Yaegashi T., Ishisaki A. "Enhancement of anti-inflammatory andosteogenic abilities of mesenchymal stem cells via cell-to-cell adhesion to periodontal ligament-derived
fibroblasts". Stem Cells International, 2017:3296498, 2017. *co-first authors.

帖佐

直幸

生化学講座
細胞情報科学分野

准教授

博士（地球環境科学）

常態系口腔科学関連③Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H., Ishisaki A., Chosa N. "Novel

医科学関連

SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem

免疫学関連cells". Scientific Reports, 4:3652, 2014.
④Jang I.H.*, Chosa N.*, Kim S.H., Nam H.J., Lemaitre B., Ochiai M., Kambris Z., Brun S., Hashimoto C., Ashida M.,
Brey P.T., Lee W.J. "A Spatzle-processing enzyme is indispensable for Toll signaling activation in Drosophila innateimmunity". Developmental Cell, 10:45-55, 2006. *co-first authors.
⑤Chosa N., Taira M., Saitoh S., Sato N., Araki Y. "Characterization of apatite formed on alkaline-heat-treated Ti".
Journal of Dental Research, 83:465-469, 2004. *co-first authors.

生化学講座氏名所属

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主な論文・著作・業績①Yokota S., Chosa N., Kyakumoto S., Kimura H., Ibi M., Kamo M., Satoh K., Ishisaki A. "ROCK/actin/MRTF
signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibularjoint". International Journal of Molecular Medicine, 39:799-808, 2017.
②Takizawa N.*,Okubo N.*,Kamo M.,Chosa N.,Mikami T.,Suzuki K.,Yokota S.,Ibi M.,Ohtsuka M.,Taira M.,YaegashiY.,Ishigaki A.,Kyakumoto S. "Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/antiinflammatory macrophages in cell to cell contact-independent and -dependent manners under hypoxicculture".Experimental Cell Research, 358:411-420,2017.*co-first authors.
③Nemoto A.,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Noda M.,Ishisaki A.,"Water-soluble factors eluated from横田聖司

生化学講座
細胞情報科学分野

助教

博士（歯学）

常態系口腔科学関連

surface pre-reached glass ionomer filler promote osteoblastic differentiation of human mesenchymal stem

病態系口腔科学関連

cells".Molecular Medicine Reports. 17:3448-3454. 2018.
④Ohta M.*,Nemoto A.*,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Shibata S.,Joh S.,Satoh K.,Ishisaki A. "Toll-likereceptor 4-mediated signaling activated by lipopolysaccharide suppresses transforming growth factor-betainduced nerve growth factor expression in periodontal ligament-derived fibroblasts".Dental Journal of Iwate
Medical University. 43:61-73. 2018.*co-first authors.
⑤Ohta M.,Chosa N.,Kyakumoto S.,Yokota S.,Okubo N.,Nemoto A.,Kamo M.,Joh S.,Satoh K.,Ishisaki A. "IL-1β andTNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts throughinactivational of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals".International Journal of Molecular
Medicine. 43:1484-1494. 2018