プログラム
Programᩍ⫱ㅮ₇
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧11:00-11:50 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸Ọ἟ ❶㸦ᮾ໭኱㝔࣭⸆㸧

EL-1㣗ࡢᏳ඲ࢆ⛉Ꮫࡍࡿ:⎔ቃởᰁ㔜㔠ᒓࡢࣜࢫࢡホ౯ࡢ⤒㦂࠿ࡽబ⸨ ὒ(ෆ㛶ᗓ࣭㣗ရᏳ඲ጤဨ఍)≉ูㅮ₇
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧11:10-12:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸㘬෬ ฼ᖾ㸦ᮾி⌮⛉኱࣭⸆㸧PL-1ᆅ⌫㸪ࡑࡋ࡚Ᏹᐂ࡜೺ᗣᮧ஭ ṇ㸦Ᏹᐂ⯟✵◊✲㛤Ⓨᶵᵓ࣭Ᏹᐂ་Ꮫ⏕≀Ꮫ◊✲ᐊ㸧

9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧17:00-18:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸⇃㇂ ჆ே㸦⟃Ἴ኱࣭་㸧PL-2╧╀࣭ぬ㓰ࡢ䭘࡟ᣮࡴ 㹼࣐࢘ࢫ࡛ࡢࣇ࢛࣮࣡ࢻ࣭ࢪ࢙ࢿࢸ࢕ࢡࢫ㹼ᰗἑ ṇྐ㸦⟃Ἴ኱࣭ᅜ㝿⤫ྜ╧╀་⛉Ꮫ◊✲ᶵᵓ(WPI-IIIS)ᶵᵓ㛗㸧Ꮫ⾡㈹≉ูㅮ₇
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧12:50-13:20 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸Ọ἟ ❶㸦ᮾ໭኱㝔࣭⸆㸧

AL1⏕ά⎔ቃ໬Ꮫ≀㉁ࡢ೺ᗣᙳ㡪࡜ឤཷᛶせᅉࡢศᏊᶵᵓ࡟㛵ࡍࡿ◊✲⚄㔝 ㏱ே㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ㸧

−17−

㒊఍㈹࣭㔠ཎ㈹ཷ㈹ㅮ₇
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧13:20-13:40 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸㘬෬ ฼ᖾ㸦ᮾி⌮⛉኱࣭⸆㸧

AL2-1

⸆ẘ≀ࡢ⣽⬊ẘᛶ࡟ᙳ㡪ࢆཬࡰࡍ⺮ⓑ㉁⩌࡟㛵ࡍࡿ◊✲㧗ᶫ ຮ㸦ᮾ໭኱㝔࣭⸆㸧

9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧13:40-14:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸ᴵⴥ ⦾⣖㸦᪥ᮏ኱࣭⸆㸧AL2-2

Aryl hydrocarbon receptor ࡢᶵ⬟ゎᯒࢆ㏻ࡌࡓࢲ࢖࢜࢟ࢩࣥ㢮ࡢẘᛶⓎ⌧ᶵᵓࡢゎ᫂࿴⏣ ᖹ 㸦᪥ᮏ኱࣭⸆㸧

ᣍᚅㅮ₇
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧10:30-11:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸ጲ㔝 ㄔ୍㑻㸦ᚨᓥᩥ⌮኱࣭⸆㸧

IL-1

High performance metabolic profiling to identify urine biomarkers incorticosteroid insensitive asthmatic children‫ۑ‬Youngja Park1, 2, Anne M Fitzpatrick3, Steven Kim1, Yongliang Liang1, andDean P Jones1 (1Department of Medicine, Emory University, 2College of
Pharmacy, Korea University, 3Department of Pediatrics, Emory University)−18−᪥㡑ḟୡ௦ࢩ࣏ࣥࢪ࣒࢘
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧14:00-15:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸 Mi-Hi Yang (Sookmyung Women's University)
Gi-Wook Hwang (Tohoku University)

S-1

Regulation of p53 by cadmium in proximal tubular cells‫ۑ‬Jin-Yong Lee1, Maki Tokumoto1, Yasuyuki Fujiwara2, Masahiko Satoh1
㸦1Sch. of Pharm., Aichi Gakuin Univ., 2Sch. of Pharm., Tokyo Univ. of Pharm.
and Life Sci.㸧

S-2

The hepatoprotective effect of sestrin2: the link between redox regulation andinflammation‫ۑ‬Sung Hwan Ki (College of Pharmacy, Chosun University, Korea)

S-3

Multi-step Regulation of Nrf2 Activity in the Liver‫ۑ‬Keiko Taguchi1,2, Hozumi Motohashi1, Masayuki Yamamoto2㸦1Gene Exp Reg,IDAC, 2Med Biochem, Grad Sch Med, Tohoku Univ㸧

S-4

Enhanced GSK3ǃ-mediated serine 33 phosphorylation of FOXL2 confers
oncogenicity to ovarian granulosa cell tumors bearing the highly conserved
C134W mutation‫ۑ‬Jeehyeon Bae (School of Pharmacy, Chung-Ang University, Korea)−19−ࣇ࢛࣮࣒ࣛ I 㸸㔠ᒓẘᛶⓎ⌧ᶵᵓゎ᫂࡬ࡢ᪂ࡓ࡞ᡓ␎
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧8:50-10:30 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸 ᑠ᳚ ᗣග㸦᫛࿴⸆኱࣭⸆㸧⸨ཎ Ὀஅ㸦ᮾி⸆኱࣭⸆㸧F1-1᭷ᶵࢫࢬ࡟ࡼࡿ GluR2 Ⓨ⌧ῶᑡࢆᡭ᥃࠿ࡾ࡟ࡋࡓ⚄⤒ᙳ㡪ゎ᫂۵ྂṊ ᘺ୍㑻㸦ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸧

F1-2

㔠ᒓ᭚㟢ࡀࡶࡓࡽࡍ࢚ࣆࢪ࢙ࢿࢸ࢕ࢵࢡ࡞ኚ໬࡜ࡑࡢศᏊᶵᵓ
۵ᮌᮧ ᭸⣖㸦ᦤ༡኱࣭⸆㸧

F1-3⭈⮚㏆఩ᒀ⣽⟶࠾ࡼࡧᾘ໬⟶࡟࠾ࡅࡿ࢝ࢻ࣑࣒࢘㍺㏦ᶵᵓ
۵⸨௦ ▖㸪ጲ㔝 ㄔ୍㑻㸦ᚨᓥᩥ⌮኱࣭⸆㸧

F1-4࣓ࢳࣝỈ㖟ẘᛶ࡜࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไᅉᏊ EGO 」ྜయ࡜ࡢ㛵ࢃࡾ‫ۑ‬㯤 ᇶ᪫㸦ᮾ໭኱㝔࣭⸆㸧ࣇ࢛࣮࣒ࣛ II㸸άᛶ࢖࢜࢘ศᏊࡢ෌Ⓨぢ࡜ࣞࢻࢵࢡࢫࣂ࢖࢜ࣟࢪ࣮ࡢ᪂ᒎ㛤
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧15:00-17:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸 ㉥ụ Ꮥ❶㸦ᮾ໭኱㝔࣭་㸧す⏣ ᇶᏹ㸦ᒸᓮ⤫ྜࣂ࢖࢜㸦⏕⌮◊㸧㸧

F2-1άᛶ࢖࢜࢘ศᏊ✀࡟ࡼࡿ㓟໬ࢫࢺࣞࢫไᚚ࡜
࣏ࣜࢧࣝࣇ࢓࣮ࣂ࢖࢜ࣟࢪ࣮
۵㉥ụ Ꮥ❶㸦ᮾ໭኱㝔࣭་㸧

F2-2᭷ᶵỈ㖟ࡢ᪂つẘᛶⓎ⌧ᶵᵓ㸸άᛶ࢖࢜࢘ศᏊࡢ NO/ROS ࣞࢻࢡࢫࢩࢢࢼࣝไᚚ
␗ᖖ۵ᒃཎ ⚽㸦኱㜰ᗓ኱㝔࣭⌮㸧

F2-3άᛶ࢖࢜࢘ศᏊ࡟ࡼࡿᚰ⮚ࣞࢻࢵࢡࢫᜏᖖᛶไᚚ۵す⏣ ᇶᏹ 1,2,3㸪እᒣ ႛኈ 1,4,6㸪㉥ụ Ꮥ❶ 5㸪⇃㇂ ჆ே 6㸦1 ᒸᓮ⤫ྜࣂ࢖࢜㸦⏕⌮◊㸧
㸪2 ஑኱㝔࣭⸆㸪3JST ࡉࡁࡀࡅ㸪4 ᮾி⌮኱࣭⸆㸪5 ᮾ໭኱㝔࣭་㸪6 ⟃Ἴ኱࣭
་㸧

F2-4

άᛶ࢖࢜࢘ྵ᭷ศᏊ࡟ࡼࡿ⏕యศᏊࡢࢩࢢࢼࣝᛂ⟅۵Ώ㑔 Ὀ⏨㸦᫛࿴⸆⛉኱࣭⸆⌮Ꮫ㸧

−20−ࣇ࢛࣮࣒ࣛ III㸸ࢼࣀ࣐ࢸࣜ࢔ࣝࡢࣜࢫࢡホ౯
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧8:50-10:50 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸 ᕷཎ Ꮫ㸦ᮾி⌮⛉኱࣭⸆㸧Ⳣ㔝 ⣧㸦ᅜ❧⾨◊㸧

F3-1ᕤᴗࢼࣀ࣐ࢸࣜ࢔ࣝࡢ⏕యᙳ㡪ᶵᗎゎ᫂ࡢࡓࡵࡢື≀ࣔࢹࣝ۵ᕷཎ Ꮫ㸯㸪࿋ 㞹፱㸰㸪Radwa Sehsah㸰㸪Esteban C. Gabazza㸱㸪ఀᮾ ೺ 4㸪ᒣᮏ 㞞அ 5㸪ᕷཎ బಖᏊ 6㸦㸯ᮾி⌮⛉኱࣭⸆㸪㸰ྡྂᒇ኱࣭་㸪㸱୕㔜኱࣭་㸪
4 ᘯ๓኱࣭་㸪5 ᮾ໭኱࣭་㸪6 ୕㔜኱࣭ᆅᇦ࢖ࣀ࣮࣋ࢩࣙࣥ㸧

F3-2ࢼࣀࣇ࢓࢖ࣂ࣮ࡢ⣽⬊ෆྲྀ㎸ࡳᶵᵓ࡜ẘᛶⓎ⌧ᶵᗎ۵ᖹ㔝 㟹ྐ㑻㸦ᅜ❧⎔ቃ◊✲ᡤ࣭⎔ቃࣜࢫࢡ◊✲ࢭࣥࢱ࣮㸧F3-3ዷፎᮇ࡟᭚㟢ࡋࡓࢼࣀ࣐ࢸࣜ࢔ࣝ࡟ࡼࡿḟୡ௦࡬ࡢᙳ㡪۵Ṋ⏣ ೺ 1㸪❧ⰼ ◊ 1,2㸪ᱵ⃝ 㞞࿴ 1㸦1 ᮾி⌮⛉኱࣭⥲ྜ◊✲ᶵᵓ㸪2 ᪥ᮏ⸆⛉኱㸧

F3-4ࢼࣀ࣐ࢸࣜ࢔ࣝࡢ᭷ᐖᛶホ౯࣭≉࡟៏ᛶẘᛶ࡟ࡘ࠸࡚۵Ⳣ㔝 ⣧㸯㸪㧗ᶫ ♸ḟ㸯㸪᳃⏣ ⣫୍㸯㸪䭜 ᫀ㈗㸯㸪㧗ᮌ ⠜ஓ㸯㸪ᑠᕝ ᖾ⏨㸯㸪ᗈ℩ ᫂ᙪ㸰㸦㸯ᅜ❧⾨◊࣭Ᏻ඲ࢭ࣭ẘᛶ㸪㸰ᅜ❧⾨◊࣭Ᏻ඲ࢭ࣭⥲ྜホ౯㸧ࣇ࢛࣮࣒ࣛ IV㸸⏕ά⎔ቃࢺ࢟ࢩࢥࣟࢪ࣮ Ѹ೺ᗣᙳ㡪◊✲ࡢ᪂ࡓ࡞࢔ࣉ࣮ࣟࢳ̾
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧14:00-16:00 A ఍ሙ㸦኱࣮࣍ࣝ㸧ᗙ㛗㸸 ⚄㔝 ㏱ே㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ㸧ᑠụ ⱥᏊ㸦ᅜ⎔◊࣭⎔ቃ೺ᗣ◊✲ࢭࣥࢱ࣮㸧F4-1⏕ά⎔ቃ໬Ꮫ≀㉁ࡀ⅖⑕࡟㛵ࢃࡿච␿ᛂ⟅࡟ཬࡰࡍᙳ㡪۵ᑠụ ⱥᏊ㸦ᅜ⎔◊࣭⎔ቃ೺ᗣ◊✲ࢭࣥࢱ࣮㸧F4-2⏕ά⎔ቃ໬Ꮫ≀㉁࡟ࡼࡿ౵ᐖ่⃭۵㤶ᕝ(⏣୰) ⪽Ꮚ 1㸪኱Ἑཎ ᫴ 2㸪⚄㔝 ㏱ே 1㸦1 ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ,
2 ஑ᕞಖ೺⚟♴኱Ꮫ⸆Ꮫ㒊㸧

F4-3⫾⏕ᮇࣉࣛࢫࢳࢵࢡྍረ๣᭚㟢ࡢḟୡ௦ᙳ㡪۵㑣㡲 ẸỤ 㸦୰㒊኱࣭⏕࿨೺ᗣ⛉Ꮫ㒊㸧

F4-4㟁☢⏺ࡤࡃ㟢࡟ࡼࡿ೺ᗣᙳ㡪۵Ḏ⏣ ᑦᶞ㸯㸪Tin-Tin- Win-Shwe㸰㸪኱㇂ ┿㸯㸪∵ᒣ ᫂㸯㸦㸯ᅜ❧ಖ೺་⒪⛉Ꮫ㝔࣭⏕ά⎔ቃ◊✲㒊, 2 ᅜ⎔◊㸧−21−ඃ⚽ⱝᡭ◊✲⪅㈹ೃ⿵⪅ࣉࣞࢮࣥࢸ࣮ࢩࣙࣥ
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧9:00-10:05 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ⇃㇂ ჆ே㸦⟃Ἴ኱࣭་㸧

P-19ప⃰ᗘࣃ࣮࢟ࣥࢯࣥ⑓㛵㐃໬Ꮫ≀㉁࡟ࡼࡿࣜࢯࢯ࣮࣒ᶵ⬟పୗ࡜࣮࢜ࢺࣇ࢓ࢪ࣮
㜼ᐖ۵ᐑⰋᨻႹ 1, 3㸪ྂṊᘺ୍㑻 1, 2㸪ᚨỌ⯟ 2㸪ኴ⏣ⱱ 1, 2㸦1 ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸪
2ᗈᓥ኱࣭⸆㸪3 Ꮫ᣺ DC㸧

P-21ࢲ࢖࢜࢟ࢩࣥࡢ⫾ඣᮇ᭚㟢࡟ࡼࡿฟ⏕ඣⓎ⫱㞀ᐖࡢ᪂つᶵᵓ㸸࿘⏘ᮇඣࡢᡂ㛗࣍ࣝࣔࣥపୗ࡟╔┠ࡋࡓゎᯒ۵᭹㒊཭⣖Ꮚ㸪Ṋ⏣▱㉳㸪⸨஭⨾ᙬ⣖ఀ㇋ᮏ࿴㤶㸪▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱㝔࣭⸆㸧

P-60᭷ᶵࢫࢬ໬ྜ≀ࡢẘᛶⓎ⌧࡟ᑐࡍࡿ Major Urinary Protein1 ࡢᙳ㡪۵㟷ᮌ ᫂㸪኱ሯ భᇶ㸪୰す ๛㸪Ọ℩ ஂග㸦ᒱ㜧⸆኱㸧

P-68㖡㘒యࢆά⏝ࡋࡓ⾑⟶ෆ⓶⣽⬊ࡢ࣓ࢱࣟࢳ࢜ࢿ࢖ࣥㄏᑟᶵᵓࡢゎᯒ۵⸨Ụᬛஓ㸯㸪୰ᐶྐ 㸪⸨ཎὈஅ 㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ྡ኱࣭≀ᅜࢭ㸪 ᮾி⌮኱࣭⥲◊ BOM㸪 ᮾி⸆኱࣭⸆㸧

P-74ᐟ୺⣽⬊ࡣ HIV ㏫㌿෗཯ᛂ㛤ጞ㜼ᐖᅉᏊ࡜ࡋ࡚ GAPDH ࢆഛ࠼ᣢࡘ
۵ᓊᮏ┤ᶞ㸯㸪㨣ሯᙬ஀㸯㸪㧗᐀ᬸᬡ㸰㸪୕㝮ᑗ࿃ 㸦㸯⇃኱㝔࣭⸆㸪㸰⇃኱ .,&2㸪⇃኱㝔࣭⏕⛉㸧P-75

C ᆺ⫢⅖࢘࢖ࣝࢫ Core ࡢ⣽⬊㉁ෆศᕸࡀᑠ⬊యࢫࢺࣞࢫ࠾ࡼࡧἜ⁲ᙧᡂࡢㄏᑟ
࡟୚࠼ࡿᙳ㡪㸸㓝ẕࣔࢹࣝࢩࢫࢸ࣒ࢆ⏝࠸ࡓゎᯒ۵ᒾబ ┿࿃㸪ᒾ஭ ೺ኴ㸪ஂୗ ࿘బ㸦ᮾ໭⸆⛉኱࣭ᚤ⏕≀Ꮫᩍᐊ㸧

P-88యෆ᫬ィ࡟ࡼࡿ⫹Ồ㓟ࡢゎẘ࠾ࡼࡧ᤼ἥᶵᵓࡢไᚚ
۵ྜྷ⏣ ㈼᪂㸪࿴⏣ ᖹ㸪ᴵⴥ ⦾⣖㸦᪥ᮏ኱࣭⸆㸧P-101

PXR άᛶ໬ࡣቑṪᅉᏊ౫Ꮡⓗ࡞⫢⣽⬊ቑṪࢆಁ㐍ࡍࡿ۵㜿㒊ኴ⣖㸯㸪ᚿὠ ᛭ኴ㸯㸪ᯇἑཌ ྜྷᡂᾈ୍ 㸦㸯ᮾ໭኱㝔࣭⸆㸪㸰㟼ᒸ┴❧኱࣭⸆㸧

P-105ࣅࢢࣜ࢝ࣥࡣ TGF-ș1 ࡜༠ㄪࡋ࡚ALK5 ⤒㊰ࢆ௓ࡋࢩࣥࢹ࢝ࣥ-4 ࡢⓎ⌧ࢆᢚไࡍࡿ۵ཎ ᓫே㸪㘬෬ ฼ᖾ㸦ᮾி⌮኱࣭⸆㸧

−22−

᪂ே㈹ೃ⿵⪅ࣉࣞࢮࣥࢸ࣮ࢩࣙࣥ
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧10:05-11:10 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ྂṊ ᘺ୍㑻㸦ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸧

P-22ࢲ࢖࢜࢟ࢩࣥ࡟ࡼࡿ⫱ඣᮇẕయࡢࣉࣟࣛࢡࢳࣥపୗ࡜ᶵᵓ࠾ࡼࡧඣࡢᡂ⇍࡬ࡢᙳ㡪۵ఀ㇋ᮏ࿴㤶㸪Ṋ⏣▱㉳㸪⸨஭⨾ᙬ⣖㸪᭹㒊཭⣖Ꮚ▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱࣭⸆㸧

P-23ࢲ࢖࢜࢟ࢩࣥẕయ᭚㟢࡟ࡼࡿඣࡢࢦࢼࢻࢺࣟࣆࣥᨺฟ࣍ࣝࣔࣥపୗࡢᐃ╔ᶵᵓ㸸࣓ࢱ࣑࣎ࣟࢡࢫ࡟ࡼࡿゎᯒ۵す⏣ᜤᏊ㸪Ṋ⏣▱㉳㸪▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱࣭⸆㸧



P-25


Ah(ࢲ࢖࢜࢟ࢩࣥ)ࣞࢭࣉࢱ࣮ࡣ⬡⫫⤌⧊࡟࠾ࡅࡿ⫧‶౫Ꮡᛶࡢ⅖⑕ㄏⓎࢆ௓ࡋ࡚⢾ᒀ⑓Ⓨ⑕࡟㛵୚ࡍࡿ۵➟಴⏤㈗㸪࿴⏣ᖹ㸪ᴵⴥ⦾⣖㸦᪥ᮏ኱࣭⸆㸧

P-32ࣜ࢞ࣥࢻࢆ௓ࡋࡓ AhR άᛶ໬࡟ཬࡰࡍ࣋ࣥࢬ࢖࣑ࢲࢰ࣮ࣝ㢮ࡢ」ྜᙳ㡪۵㛗⃝⪷Ꮚ㸯㸪㛵ᮏᚁྐ㸯㸪⏣ᓮឡె㸯㸪すᕝ⛅ె 㸪ᱵᮧ㝯ᚿ 㸪᰿ᮏΎග㸯㸪ྜྷᡂᾈ୍㸯㸪ฟᕝ㞞㑥㸯㸦㸯㟼ᒸ┴❧኱࣭⸆࣭⾨⏕ศᏊẘᛶᏛ㸪㸰ᅜ❧⾨◊㸧P-45ᇵ㣴ࣄࢺ⬻ᚤᑠ⾑⟶ෆ⓶⣽⬊ࡢ⥺⁐⣔࡟ᑐࡍࡿ࣓ࢳࣝỈ㖟ࡢẘᛶⓎ⌧۵⏣୰⨾ᕹ㸯㸪ᰩ⏣㈼㸯㸪ྜྷ⏣ᫎᏊ㸯㸪ᒣᮏ༓ኟ㸰㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭⸆㸧

P-51

ࣜࣥࣃ⫗⭘⣽⬊ P1798 ࡬ࡢ࢝ࢻ࣑࣒࢘㛗ᮇฎ⌮࡟ࡼࡿ࣓ࢱࣟࢳ࢜ࢿ࢖ࣥㄏᑟ⬟ࡢኚ໬۵⚟ᮏ ෤㔛㸪ᮌᮧ ⰋᏱ㸪ಖᆏ ༟⮧㸪ᮌᮧ ᭸⣖㸦ᦤ༡኱࣭⸆㸧P-59༸ᕢᶵ⬟࡟ࡼࡿ TPT ẘᛶⓎ⌧ಟ㣭۵኱ሯ భᇶ㸪㟷ᮌ ᫂㸪୰す ๛㸪Ọ℩ ஂග㸦ᒱ㜧⸆኱࣭⸆㸧

P-84࣐ࢡࣟࣇ࢓࣮ࢪ࡟ࡼࡿࣞࢭࣉࢱ࣮ࢱࣥࣃࢡ㉁ࢾࢡࣞ࢜ࣜࣥࢆ௓ࡋࡓኚᛶ LDL ࡢㄆ㆑‫ెⰼ❧ۑ‬ᘯ㸯኱‖♸ຍ㔛㸯୕ᮌ㞝୍㸯ᖹ㔝࿴ஓ㸰ูᗓṇᩄ㸯⸨ཎὈஅ㸯 㸯ᮾி⸆⛉኱࣭⸆㸪㸰㧗ᓮ೺ᗣ⚟♴኱࣭⸆ 

P-87࢔࣏ࢺ࣮ࢩࢫ㜼ᐖ๣࣎ࣥࢡࣞ࢟ࣥ㓟ࡢ᪂ࡓ࡞⏕≀άᛶ: PPARȚࡢ㑅ᢥⓗάᛶ໬๣࡜ࡋ࡚ࡢ᭷⏝ᛶ۵㇂ཱྀ ᙬ 1, ụ⏣ ᜨ⌮Ꮚ 1, ➉⏣ ಟ୕ 2, ᚨᏳ ⨾⣖ 1, ▼஭ ᏹᖾ 1, ྜྷᒸ 㟹ྐ 1,
すᮧ ⫕ 1, ᒸᓮ ⿱அ 1, ᯇᮏ ೺ྖ 3, ᪂⸨ ඘ 3, Ⲩ∾ ᘯ⠊ 1 (1 ➨୍⸆኱, 2 ᗈᓥᅜ㝿኱࣭⸆, 3 ஑ᕞ኱࣭ඛᑟ◊)19 ᪥ࡢ᠓ぶ఍࡟࡚ඃ⚽ⱝᡭ◊✲⪅㈹࠾ࡼࡧ᪂ே㈹ࢆ⾲ᙲணᐃ−23−

୍⯡ㅮ₇㸦ཱྀ㢌㸧⎔ቃởᰁ≀㉁ 1
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧15:10-16:00 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ᖹ㔝 㟹ྐ㑻㸦ᅜ⎔◊㸧㛵ᮏ ᚁྐ㸦㟼ᒸ┴❧኱࣭⸆㸧

O1-1࣮࢝࣎ࣥࣈࣛࢵࢡࢼࣀ⢏Ꮚࡢ⫾௘ᮇ᭚㟢ࡀ᪂⏕௘ච␿⣔࡟ཬࡰࡍᙳ㡪ࡢ᭚㟢᫬ᮇ࡟ࡼࡿᕪ␗
۵ᑠ㔝⏣ ῟ே 1,2㸪ᒸᮏ Ἃ⣖ 1㸪ΎỈ 㝯ᖹ 1㸪ᑠᕝ ಟᖹ 2,3㸪Ώ㎶ ᚿᕹ 3㸪Ᏻ㒊 Ⰻ 3㸪Ṋ⏣ ೺ 2㸪ᱵ⃝ 㞞࿴ 2㸦1 ᮾி⌮኱㝔࣭⸆㸪2 ᮾி⌮኱࣭⥲◊࣭⎔ቃḟୡ௦ࢭ㸪3 ᮾி⌮኱࣭⏕࿨◊㸧

O1-2

Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory
response to bleomycin-induced pulmonary fibrosis in mice
۵Wenting Wu1, Gaku Ichihara2, Naozumi Hashimoto3, Yoshinori Hasegawa3,
Yasuhiko Hayashi4, Masashi Kato1, Saeko Tada-Oikawa5, Yuka Suzuki5,
Jie Chang1, Corina N. D'Alessandro-Gabazza6, Esteban C. Gabazza6,
Sahoko Ichihara5 (1Department of Occupational and Environmental Health,
Nagoya University Graduate School of Medicine, 2Department of Occupational
and Environmental Health, Tokyo University of Science, Japan㸪3Departmentof Respiratory Medicine, Nagoya University Graduate School of Medicine,
4Department of Electrical and Electronic Engineering, Okayama University,
5Graduate School of Regional Innovation Studies, Mie University, 6Department
of Immunology, Mie University School of Medicine)

O1-3

Involvement of Nrf-2 in zinc oxide nanoparticles-induced pulmonary
inflammation
۵Radwa Sehsah1, 6, Wenting Wu1, Sahoko Ichihara2, Naozumi Hashimoto3,
Yoshinori Hasegawa3, Ken Ito4, Masayuki Yamamoto5, Emily Kamel6,
Gaku Ichihara7 (1Department of Occupational and Environmental Health,
Nagoya University Graduate School of Medicine, 2Mie University Graduate
School of Regional Innovation Studies, 3Department of Respiratory Medicine,
Nagoya University Graduate School of Medicine, 4Department of StressResponse Medicine, Hirosaki University Graduate School of Medicine,
5Department of Medical Biochemistry, Tohoku University Gradute School of
Medicine, 6Department of Public Health and Community Medicine, Mansoura
Faculty of Medicine, Egypt, 7Department of Occupational and Environmental
Health, Tokyo University of Science. )

O1-4⮯⣲⣔㞴⇞๣࣊࢟ࢧࣈࣟࣔࢩࢡࣟࢻࢹ࢝ࣥࡀ㣗䭱ᛶ⫧‶࣐࢘ࢫࣔࢹࣝࡢ⢾࣭⬡㉁௦ㅰ࡟ཬࡰࡍᙳ㡪۵ᰗ⃝฼ᯞ㸯㸪ᑠụⱥᏊ㸯㸪7LQ7LQ:LQ6KZH㸯㸪㧗㔝⿱ஂ㸰  ⎔ቃ◊࣭೺ᗣࢭࣥ
ࢱ࣮㸪 ி㒔኱㝔࣭ᕤ −24−⎔ቃởᰁ≀㉁ 2࣭⬻࣭⚄⤒ẘᛶ≀㉁࣭⏕໬Ꮫ
9 ᭶ 19 ᪥㸦➨ 1 ᪥┠㸧16:00-16:50 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ゅ ኱ᝅ㸦ᚨᓥᩥ⌮኱࣭⸆㸧᳜⏣ ᗣḟ㸦ྡᇛ኱࣭⸆㸧O2-1

࣋ࣥࢰ[a]ࣆࣞࣥ⫾௘ᮇ᭚㟢ࡣ㞝ᛶ⏕Ṫᶵ⬟ࢆ㞀ᐖࡍࡿ۵⇃ᮏ 㝯அ㸪ᑠᓟ ᗣᏕ㸪㧘ᰡ ┤⣖㸪ᢲᑿ ⱱ㸦ዟ⩚኱࣭⸆㸧

O2-2

Detection of epigenetic effects induced by environmental chemicals in mouse
ES cells harboring GFP-MBD-lns
۵Wenlong WANG1㸪Qin ZENG1㸪Hiroko NANSAI1, Kuniya ABE2,
Hideko SONE1 (1National Institute for Environmental Studies, 2Riken
BioResource center)O2-3

࣐࢘ࢫⓎ㐩ᮇ࡟࠾ࡅࡿ୰㛫࿘Ἴ☢⏺᭚㟢ࡢ⚄⤒ẘᛶ۵࢘࢕ࣥࢩࣗ࢖ࢸ࢕ࣥࢸ࢕ࣥ㸯㸪኱㇂┿㸰㸪∵ᒣ᫂㸰㸪Ḏ⏣ᑦᶞ㸰㸦㸯ᅜ❧⎔ቃ◊✲ᡤ㸪㸰ᅜ❧ಖ೺་⒪⛉Ꮫ㝔㸧

O2-4࣏ࣜ࢝ࣜࣥࣇ࢓࣑࣮ࣜศᏊ㹋㹓㹎㸯࡟ࡼࡿ⢾࣭⬡㉁௦ㅰไᚚࢆ௓ࡋࡓ⬡⫫⵳✚ᢚไᶵᵓࡢ᳨ウ۵⸨㇂⯟ᖹ㸪㟷ᮌ᫂㸪୰す๛㸪Ọ℩ஂග㸦ᒱ㜧⸆኱㸧

−25−ෆศἪᨩ஘໬Ꮫ≀㉁9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧9:00-10:00 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ᒣ⏣ⱥஅ㸦஑ᕞ኱㝔࣭⸆㸧➉⏣ ಟ୕㸦ᗈᓥᅜ㝿኱࣭⸆㸧

O3-1ࣆࣞࢫࣟ࢖ࢻ⣔࠾ࡼࡧ࢝ࣝࣂ࣓࣮ࢺ⣔㎰⸆ࡢࣛࢵࢺ PXR㸪CAR ࠾ࡼࡧ PPARȘάᛶ࡜⫢௦ㅰ࡟ࡼࡿᙳ㡪۵⸨㔝ᬛᜨ㔛㸯㸪Ώ㒊ᐜᏊ㸯㸪ᾆ୸┤ே㸯㸪ᑠᓥᘯᖾ㸰㸪ྜྷᡂᾈ୍㸱㸲㸪໭ᮧ⦾ᖾ㸯㸦㸯᪥ᮏ⸆኱㸪㸰໭ᾏ㐨⾨◊㸪㸱㟼ᒸ┴❧኱࣭⸆㸪㸲ᮾ໭኱࣭㝔࣭⸆㸧

O3-2

ࣄࢺ⫢⣽⬊HepaRG ࡟࠾ࡅࡿ⎔ቃ໬Ꮫ≀㉁ࡢ⣽⬊ẘᛶ࡜⸆≀௦ㅰ㓝⣲ㄏᑟ⬟࡟ࡘ࠸࡚۵᭮᰿⚽Ꮚ㸯㸪ᮧᒣ඾ᜨ㸰㸪⋤ᩥ㱟㸯㸪༡㰻ࡦࢁᏊ㸯㸪᭯໅㸯㸪ᒣᓮᾈྐ㸰㸦㸯ᅜ❧⎔ቃ◊࣭⎔ቃࣜࢫࢡ㸪㸰᫛࿴⸆኱࣭⸆≀ືែᏛ㸧

O3-3

⫢⮚ AhR ࡟ࡼࡿ⬡⫫ẘᛶᢚไస⏝۵࿴⏣ ᖹ㸪ᐑ⏣ ࿴㍤㸪㡲Ọ ὒ, ⓑᓮ ᫓㔝, ෆᒣ ⏤㈗, ᴵⴥ ⦾⣖㸦᪥ᮏ኱࣭⸆㸧O3-4ࢲ࢖࢜࢟ࢩࣥ࡟ࡼࡿࣟ࢖ࢥࢺ࢚ࣜࣥ B4 ྜᡂஹ㐍㸸ᶵᵓ࠾ࡼࡧ⅖⑕ࢆྵࡴ㞀ᐖᛶ࡜ࡢ㛵㐃۵ᑠᐑ⏤ᏘᏊ 㸪Ṋ⏣▱㉳ 㸪ᮌᗞᙲᙪ 㸪▼஭♸ḟ 㸪௰▮㐨㞝 㸪㯮℩➼ 㸪ᶓ⁁ᓅᙪ 㸪ΎỈᏕ㞝 㸪ෆ༤ྐ㸲㸪ྂỤቑ㝯㸲㸪ᒣ⏣ⱥஅ   ஑ᕞ኱㝔࣭⸆㸪㸰㡰ኳᇽ኱㝔࣭་㸪 ᅜ㝿་⒪◊✲ࢭ㸪 ஑ᕞ኱⑓㝔O3-5

࿘⏘ᮇ TCDD ᭚㟢࣐࢘ࢫ࡟࠾ࡅࡿ኱⬻⓶㉁㎶⦕⣔̺どᗋୗ㒊̺ୗᆶయ̺๪⭈㍈ࡢẘᛶᙳ㡪۵࣋ࢼ࣮⪷Ꮚ㸯㸪୎㞼₩㸯㸪஭ୗኴ㈗㸯㸪᥃ᒣṇᚰ㸰㸪㐲ᒣ༓᫓㸯㸦㸯ᮾ኱㝔࣭་㸪㸰㛗ᓮ኱㝔࣭་ṑ⸆㸧

−26−㓟໬ࢫࢺࣞࢫ࣭⣽⬊ᛂ⟅9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧10:00-11:00 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ཎ ಇኴ㑻㸦᫛࿴኱࣭⸆㸧㜿༡ ᘺᑑ⨾㸦᫛࿴⸆⛉኱࣭⸆㸧

O4-1ࢱ࣏ࣛࣝࣇ࢕ࣥࢼࢺ࣒ࣜ࢘ࢆ⏝࠸ࡓග⥺ຊᏛ⒪ἲ࡟ࡼࡾ⬻⭘⒆⣽⬊࡟ㄏᑟࡉࢀࡿ
⣽⬊Ṛᙧែࡢ᳨ウ‫୕ۑ‬ᮌ 㞝୍㸯㸪⛅ඖ ἞ᮁ㸰㸪ᘯ୰ ༓ᑜ㸯㸪ูᗓ ṇᩄ㸯㸪⸨ཎ Ὀஅ㸯㸦㸯ᮾி⸆኱࣭
⸆㸪㸰ᮾி་኱࣭་㸧O4-2⬡㉁㓟໬ࡀ㉳ᅉ࡜࡞ࡿ᪂つ⣽⬊Ṛࡢࢩࢢࢼࣝఏ㐩⤒㊰ࡢゎ᫂۵ᯇᒸṇᇛ㸯ཎ⏣᫴స ᪂஭ὒ⏤ ௒஭ᾈᏕ㸯㸦㸯໭㔛኱࣭⸆ ᮾ኱㝔࣭⸆㸧

O4-3

㓟⣲ࢫࢺࣞࢫㄏⓎᛶ NF-ȡB άᛶ໬࡟࠾ࡅࡿ⮬↛ච␿᝟ሗఏ㐩⣔ࡢ㛵୚‫ۑ‬᪩ᕝ☻⣖⏨㸪ྂ㒆ᬛྐ㸪἞㑻୸Ἃᕼᯇ஭ᬛ⨾㣤⏣ኟ⨾㸦ᮾி⸆⛉኱࣭⸆㸧㐣㓟໬Ỉ⣲ࡣࣄ⣲࣓ࢳࣝᇶ㌿⛣㓝⣲ࡢ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢࢆច㉳ࡍࡿ۵ゅ ኱ᝅ㸪➉⏣ᬛ⍛㔛㸪ጲ㔝ㄔ୍㑻㸦ᚨᓥᩥ⌮኱࣭⸆㸧



O4-4


O4-5

ᑠ⬊యࢫࢺࣞࢫㄏᑟᛶࢱࣥࣃࢡ㉁ TRB3 ࡟ࡼࡿ࢖ࣥࢱ࣮ࣟ࢖࢟ࣥ 2 ࡢⓎ⌧ไᚚ۵㔝ཎ໶㸪ᮡᒣ࿴ᘺ㸪ᐑᔱࡕࡣࡿ㸪ఀ⸨཭㤶㸪஭ୖ㟹㐨㸪ᯘ⚽ᩄ㸦ྡᕷ኱㝔࣭
⸆㸧

−27−

㔠ᒓ
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧14:10-15:10 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 ᒣᮏ ༓ኟ㸦ᮾ㑥኱࣭⸆㸧໭ ຍ௦Ꮚ㸦ᖇி኱࣭⸆㸧O5-1↓ᶵࣄ⣲᭚㟢࡟ࡼࡿ p16-cdk4 」ྜయቑຍࢆ௓ࡋࡓࣜࣥࣃ⌫ቑṪᢚไᶵᗎ۵ᒸᮧ࿴ᖾ㸪㔝ཎᜨᏊ㸦ᅜ❧⎔ቃ◊✲ᡤ ⎔ቃ೺ᗣ◊✲ࢭࣥࢱ࣮㸧

O5-2

࣓ࢳࣝỈ㖟᭚㟢ᣦᶆ࡜ࡋ࡚ࡢዷፎึᮇ࡜ฟ⏘ᮇࡢ∎ࡢព⩏:༢఩㛗ẟ㧥Ỉ㖟⃰ᗘ࠿ࡽࡳࡓ∎࡬ࡢỈ㖟⛣⾜ࡢゎᯒ‫ۑ‬ᆏᮏ ᓠ⮳ 1㸪ᮧ⏣ ຾ᩗ 2㸦1 ᅜ❧Ỉಛ⑓⥲ྜ◊✲ࢭࣥࢱ࣮⎔ቃ࣭␿Ꮫ◊✲㒊㸪
2 ⛅⏣኱࣭་࣭♫఍⎔ቃ་Ꮫㅮᗙ࣭⎔ቃಖ೺Ꮫศ㔝㸧O5-3

᰾☢Ẽඹ㬆⏬ീἲࢆ⏝࠸ࡓ࣓ࢳࣝỈ㖟ᢞ୚࡟ࡼࡾ⏕ࡌࡿ⬻ෆ㓟໬࡜⚄⤒ᶵ⬟␗ᖖᐃࡢヨࡳ۵▼ཎᗣᏹ㸯㸪ఀ⸨ᗣ୍㸰㸪㧗ᶫுᖹ㸯㸪▼⏣ᩔᙪ㸯㸪ᒣ㷂ᓅ㸯㸦㸯ᗈᓥ኱࣭⥲ྜ⛉Ꮫ㸪㸰ᚨᓥᩥ⌮኱࣭㤶ᕝ⸆㸧

O5-4

࣓ࢳࣝỈ㖟࡟ࡼࡾᘬࡁ㉳ࡇࡉࢀࡿ࢔ࢫࢺࣟࢧ࢖ࢺ㐺ᛂᛂ⟅࡜ࡑࡢ⚄⤒ಖㆤస⏝۵➉ᮏᣅ▮㸪▼ཎᗣᏹ㸪▼⏣ᩔᙪᒣᓮᓅ㸦ᗈᓥ኱࣭⥲ྜ⛉Ꮫ㸧

O5-5࣓ࢳࣝỈ㖟࡟ࡼࡿᚰ⮚ࣜࢫࢡቑ኱ࡢศᏊ࣓࢝ࢽࢬ࣒
۵እᒣႛኈ 㸪⇃㇂჆ே 㸪㘬෬฼ᖾ 㸪㉥ụᏕ❶ 㸪す⏣ᇶᏹ㸯㸦㸯ᒸᓮ⤫ྜࣂ࢖࢜㸦⏕⌮◊㸧㸪 ᮾி⌮኱࣭⸆㸪 ᪥ᮏᏛ⾡᣺⯆఍ 3' 㸪 ⟃Ἴ኱࣭་㸪 ᮾ໭኱࣭་㸪 ஑኱㝔࣭⸆㸪-67 ࡉࡁࡀࡅ㸧





−28−

ච␿ẘᛶ࣭ឤᰁ⑕࣭ࡑࡢ௚
9 ᭶ 20 ᪥㸦➨ 2 ᪥┠㸧15:10-16:00 B ఍ሙ㸦኱఍㆟ᐊ 102㸧ᗙ㛗㸸 Ọ℩ ஂග㸦ᒱ㜧⸆኱࣭⸆㸧Ṋ⏣ ▱㉳㸦஑ᕞ኱㝔࣭⸆㸧

O6-1

Mycobacterium bovis BCG ࡢ㓟໬ࢫࢺࣞࢫ࡟ࡼࡿredox 㛵㐃㑇ఏᏊⓎ⌧ኚ໬ࡢゎᯒ‫ۑ‬㧗ぢ⠜㑻 㸪ᐩ⏣㝧㤶 㸪๓ᒣ㡰୍ 㸪ᒣᮏ୕㑻 㸪℧஭⊛ᑗ 㸦 ྡᕷ኱࣭㝔⸆࣭⾨⏕໬Ꮫ㸪 ᅜ❧ឤᰁ◊࣭Ᏻ඲ᛶ㸪 ᪥ᮏ %&*࣭◊✲ᡤ㸧

O6-2

ࢩࢥࢽࣥ࡜ LPS ࡟ࡼࡗ࡚ᛴ㏿࡟ㄏᑟࡉࢀࡿ࣐ࢡࣟࣇ࢓࣮ࢪࡢ⣽⬊㞀ᐖᛶࡢゎᯒ۵ᑠụᩔ㈨Ⱚ㔝┿႐㞝᳃⚽ஓᑠ℈ΎᏊ⸨᳃ຌ㸪ኳ㔝ᐩ⨾ኵ㸦኱㜰⸆
኱࣭⸆㸧

O6-3

㯤◁௜╔ᚤ⏕≀⏤᮶ᡂศࡢ LPS ࡟ࡼࡿ㞝ᛶ⏕Ṫᶵ⬟࡬ࡢᙳ㡪۵ྜྷ⏣ ᡂ୍㸪ᕷ℩ Ꮥ㐨㸦኱ศ┴❧┳⛉኱࣭⏕య཯ᛂᏛ㸧

O6-4

Ᏹᐂᒃఫ⎔ቃ࡟࠾ࡅࡿon-site ᚤ⏕≀ࣔࢽࢱࣜࣥࢢࢆ┠ᣦࡋࡓ࣐࢖ࢡࣟὶ㊰ࢩࢫࢸ࣒ࡢ㛤Ⓨ۵ᒣཱྀ 㐍ᗣ㸪⸨஭ 㞝኱㸪㑣㡲 ṇኵ㸦኱㜰኱㝔࣭⸆㸧

−29−

୍⯡ㅮ₇㸦࣏ࢫࢱ࣮㸧 ୰఍㆟ᐊ 201, 202
ወᩘ␒ྕ㸸➨ 1 ᪥┠Ⓨ⾲㸦13:00-14:00㸧
㸪അᩘ␒ྕ㸸➨ 2 ᪥┠Ⓨ⾲㸦16:00-17:00㸧
⎔ቃởᰁ≀㉁P-1᪥ᮏᾏἢᓊ 3 ┴࡟࠾ࡅࡿ෤Ꮨཬࡧ᫓Ꮨࡢ㉺ቃ኱Ẽởᰁࡢゎᯒ‫ ࣐ࣥ࢖ࣞࢫࣜࣂࣜࢗࢡۑ‬㸪ᒣ⏣┿⿱ 㸪ᑠ㔝㑈 㸪༡჆㍤ 㸪㜿㒊┿ᕹ 㸪㈗ᚿⲁ⾰ 㸪ᯇ஭ඖᕼ 㸪㛗㇂஭཭ᑜ 㸪ୡⰋᬸஅ 㸪኱࿅ᛅྖ 㸪ᮌᡞ⍞ె 㸪⯪ᆏ㑥ᘯ 㸪ὸᕝ኱ᆅ 㸪Ώ㒊ோᡂ 㸪ⱝᯘᩗ஧ 㸪Ώ㎶ᚭᚿ 㸦 ி㒔⸆኱㸪⚟ᒸ┴ಖ⎔◊㸪 㫽ྲྀ┴⾨⎔◊㸪 ᐩᒣ┴⎔⛉ࢭ㸪 ኱㜰ᕷ⎔⛉◊㸪 㫽ྲྀ኱㸪 㟼ᒸ
┴኱㸧

P-2

᪥ᮏᾏཬࡧ୰ᅜ㛗Ụ࡟࠾ࡅࡿከ⎔ⰾ㤶᪘Ⅳ໬Ỉ⣲㢮ࡢ⃰ᗘ᥎⛣۵∾㔝ྐᘺ㸯㸪၈ᑀ㸯㸪㫽⩚㝧㸯㸪ຌยṇ⾜㸰㸪᪩ᕝ࿴୍㸯㸪㸰㸦㸯㔠ἑ኱࣭⸆㸪㸰㔠ἑ኱࣭⎔᪥ࢭ㸧

P-3

1,2-ࢼࣇࢺ࢟ࣀࣥࡀ࣐࢘ࢫ⫵୰࡛♧ࡍኚ␗ཎᛶ ۵㟷ᮌ ᗣᒎ㸯㸪ᯇᮏ ࡳࡕࡼ㸯㸪ᰗ⃝ ฼ᯞ㸰㸪ᯇᮏ ⌮㸯㸪୰ᓥ ኱௓㸯㸦1 ᅜ❧⎔ቃ◊✲ᡤ࣭⎔ቃࣜࢫࢡ◊✲ࢭࣥࢱ࣮㸪2 ⎔ቃ೺ᗣ◊✲ࢭࣥࢱ࣮㸧

P-4

PM2.5 ࡜ PM10 ࡢẼ⟶ᨭႍᜥࣔࢹ࣐ࣝ࢘ࢫ࡬ࡢᙳ㡪۵ᕷ℩Ꮥ㐨㸯㸪ྜྷ⏣ᡂ୍㸯㸪+H0LDR㸰㸦㸯኱ศ┳⛉኱࣭┳㸪㸰୰ᅜ་⛉኱࣭බ⾗⾨⏕㸧

P-5ィ⟬໬Ꮫ࡟ࡼࡿ᥹Ⓨᛶ᭷ᶵ໬ྜ≀ࡢ⤒㰯྾཰ᛶண ࡟㛵ࡍࡿ◊✲۵⚄㔝 ㏱ே 1㸪㤶ᕝ㸦⏣୰㸧 ⪽Ꮚ 1㸪⏣ཎ 㯞⾰Ꮚ 1㸪ᕝཎ 㝧Ꮚ 1㸪┿ᘪ ຍ⧊ 1㸪
஬༑ᔒ Ⰻ᫂ 1㸪ᇰᒸ ఙග 2㸦1 ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ㸪2 ᶓ὾⸆⛉኱㸧

P-6஧㓟໬ࢳࢱࣥࢼࣀ⢏Ꮚࡢ⫾௘ᮇ᭚㟢࡟ࡼࡾ⚄⤒ᖿ⣽⬊࡟⏕ࡌࡿ㑇ఏᏊⓎ⌧ኚື۵ᑠ␒⨾㕥㸯㸰㸪❧ⰼ◊㸰㸱ᕝ๪⩧ኴ㑻㸯㸰ୖ⏣๛ྖ㸯᪂ᾏ㞝௓㸰ᱵ⃝㞞࿴㸰Ṋ⏣೺㸰㸦㸯ᮾி⌮኱㝔࣭⸆㸪㸰ᮾி⌮኱࣭⥲◊࣭⎔ቃḟୡ௦ࢭ㸱᪥ᮏ⸆⛉኱㸧

P-7࣮࢝࣎ࣥࣈࣛࢵࢡࢼࣀ⢏Ꮚ᭚㟢ࡀ N-3 ⣔ከ౯୙㣬࿴⬡⫫㓟Ḟஈ㣗ࢆᦤྲྀࡋࡓ࣐࢘
ࢫ࡟ཬࡰࡍᙳ㡪۵୰ᮧோᖾ 㸪ᇼᐶ 㸪⏣⏿┿బᏊ 㸪ஂಖ⏣ኟᏊ 㸪Ṋ⏣೺ 㸪ᱵ⃝㞞࿴ 㸦 ᮾி⌮኱࣭⸆㸪 ᮾி⌮኱࣭⥲◊࣭⎔ቃḟୡ௦ࢭ㸧

P-8⫾ඣᮇࡢ⎔ቃởᰁ≀㉁᭚㟢࡜ IGF-1 ཬࡧฟ⏕ඣయ㔜࡜ࡢ㛵㐃
1 1
۵ᒾ஭ ⨾ᖾ 1,2, 㱟⏣ ᕼ 3, ௰஭ 㑥ᙪ 3, 㯮ᕝ ಟ⾜ 4, బ⸨ ὒ 3, Ọ἟ ❶ 㸦ᮾ໭኱㝔࣭⸆, 2 Ꮫ᣺≉ู◊✲ဨ PD,3 ᮾ໭኱㝔࣭་,4 ᐑᇛᩍ⫱኱㸧

P-9ྍረ๣ࣇࢱࣝ㓟࢚ࢫࢸࣝ㢮ࡢᐊෆ⎔ቃືែ㸸ࣁ࢘ࢫࢲࢫࢺ୰ࡢຍỈศゎ⏕ᡂ≀۵⏣ཎ㯞⾰Ꮚ㤶ᕝ ⏣୰ ⪽Ꮚᕝཎ㝧Ꮚ஬༑ᔒⰋ᫂⚄㔝㏱ே㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ࣭⏕ά⾨⏕໬Ꮫ㒊㸧





−30−

P-10

ࣁ࢘ࢫࢲࢫࢺࢆ௓ࡍࡿ PCB ࡢ᭚㟢ホ౯۵㤶ᕝ㸦⏣୰㸧⪽Ꮚ 㸪⏣ཎ㯞⾰Ꮚ 㸪ᒾ⏣┤ᶞ 㸪㧗Ⳣ༟୕ 㸪ᕝཎ㝧Ꮚ 㸪┿ᘪຍ⧊ 㸪஬༑ᔒⰋ᫂ 㸪⚄㔝㏱ே 㸦㸯ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ㸪㸰㸦ᰴ㸧ᓥὠࢸࢡࣀࣜࢧ࣮ࢳ㸧

P-11ᒃఫఫᏯ࡟࠾ࡅࡿᐊෆ⎔ቃ୰ࡢྍረ๣ཬࡧ᭷ᶵࣜࣥ⣔㞴⇞๣ࡢศูᐃ㔞۵Ṋෆఙ἞㸯㸪⚄࿴ኵ㸯㸪బ⸨ṇᖾ㸯㸪ᑠᯘᬛ㸯㸪ᑠᓥᘯᖾ㸯㸪ᩪ⸨⫱Ụ㸰㸪ୖᮧோ㸱㸪㤶ᕝ㸦⏣୰㸧⪽Ꮚ㸲㸪⚄㔝㏱ே㸲㸦㸯໭ᾏ㐨⾨◊㸪㸰㒔೺Ᏻ◊ࢭ㸪㸱⚄ዉᕝ⾨◊㸪㸲ᅜ❧⾨◊㸧P-12஧ḟ⏕ᡂ᭷ᶵ࢚࢔ࣟࢰࣝࡢᵓᡂᡂศ࡟ࡼࡿ㓟໬ࢫࢺࣞࢫ཯ᛂࡢㄏᑟ
۵ఀ⸨ᬛᙪ㸪ᡞḟ ຍዉỤ㸪ᖹ㔝 㟹ྐ㑻㸦ᅜ❧⎔ቃ◊㸧Ⓨࡀࢇᛶ≀㉁P-13

᪂つ࡞ hydroxylated S-ྵ᭷ PCB ௦ㅰ≀ࡢ⏕ᡂ࡟㛵୚ࡍࡿࣄࢺ cytochrome
P450(CYP)ศᏊ✀۵ᓥ㈗ᐶ㸪୰஭ࡦ࡜ࡳ㸪ᕷᒣ⍛⌮㸪༡ᲄ⍞✑㸪ᡞ⏣ᬗஂ㸪㯮ᮌᗈ᫂㸦➨୍⸆
኱࣭⸆㸧

P-14

ࢩࢺࢡ࣒ࣟ P450 3A4 (CYP3A4) ࡜ UDP-ࢢࣝࢡࣟࣥ㓟㌿⛣㓝⣲(UGT) ࡢ ᶵ⬟ⓗ┦஫స⏝㸸 CYP3A4 ࡣ UGT1A7 㑇ఏᏊከᆺ౫Ꮡⓗ࡟ UGT ᶵ⬟ࢆኚືࡉࡏ
ࡿ‫ۑ‬Ụ㉺ ⳯᭶ 1㸪▼஭ ♸ḟ 1㸪ᮌୗ ஽భ 1㸪ྂⴥ ᘯᶞ 1㸪⏕ᇛ ┿୍ 2㸪Ọ⏣ Ύ 3㸪ᒣῧ ᗣ 4㸪Peter I. Mackenzie5㸪ᒣ⏣ ⱥஅ 1 (1 ஑኱㝔࣭⸆㸪2 ᐩᒣ┴❧኱࣭ᕤ㸪
3 ᮾ໭⸆⛉኱㸪4 ෆ㛶ᗓ㸪5 ࣇࣜࣥࢲ࣮ࢫ኱࣭་)P-15

ዷፎᮇ↓ᶵࣄ⣲᭚㟢࡟ࡼࡿ F2 㞝࣐࢘ࢫ࡛ࡢ⫢⭘⒆ቑຍࡢᶵᗎࡢ᥈⣴۵㔝ཎᜨᏊ㸯㸪ᒸᮧ࿴ᖾ㸯㸪㕥ᮌṊ༤㸯㸪ᮧ஭ᬒ㸯㸪ᑠᇼ┿⌔Ꮚ㸰㸦㸯ᅜ❧⎔ቃ◊࣭⎔ቃ೺ᗣ C㸪㸰㎰◊ᶵᵓ䞉㣗⥲◊㸧

P-16࣐࢘ࢫ⫢⮚⒴⣽⬊ᰴ࡟࠾ࡅࡿ↓ᶵࣄ⣲࡟ࡼࡿ Fosb ࡢⓎ⌧࡜ DNA ࣓ࢳࣝ໬ኚ໬
۵㕥ᮌṊ༤㸪㔝ཎᜨᏊ㸦ᅜ❧⎔ቃ◊✲ᡤ⎔ቃ೺ᗣ◊✲ࢭࣥࢱ࣮㸧⬻࣭⚄⤒ẘᛶ≀㉁

P-17

PC12 ⣽⬊ࡢ⚄⤒✺㉳ఙ㛗࡟ᑐࡍࡿከ⎔ⰾ㤶᪘Ⅳ໬Ỉ⣲ࡢຠᯝ۵ᮌୗ⏤ె㸪୰すᙬ㤶㸪ᕤ⸨᫂ᫍ┾⏣ἲᏊᮌὠⰋ୍㸦ྠᚿ♫ዪ኱࣭⸆㸧

P-18࣑ࢺࢥࣥࢻࣜ࢔࿧྾㙐㜼ᐖ๣࡟ࡼࡿ EAAT3 Ⓨ⌧ୖ᪼࡜ࡑࡢ࣓࢝ࢽࢬ࣒ゎ᫂
۵㊊❧ᬡ㸯㸪ྂṊᘺ୍㑻㸯㸪ᒣᮏᬛ⨾ Ⳣ⏣࿴Ꮚ ኴ⏣ⱱ 㸦㸯ᗈᓥ኱࣭⸆㸪㸰ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸧



−31−

P-19

ప⃰ᗘࣃ࣮࢟ࣥࢯࣥ⑓㛵㐃໬Ꮫ≀㉁࡟ࡼࡿࣜࢯࢯ࣮࣒ᶵ⬟పୗ࡜࣮࢜ࢺࣇ࢓ࢪ࣮
㜼ᐖ۵ᐑⰋᨻႹ 1, 3㸪ྂṊᘺ୍㑻 1, 2㸪ᚨỌ⯟ 2㸪ኴ⏣ⱱ 1, 2㸦1 ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸪
2ᗈᓥ኱࣭⸆㸪3 Ꮫ᣺ DC㸧

P-20⚄⤒⣽⬊࡟࠾ࡅࡿ AhR ࢩࢢࢼࣝࡢάᛶ໬ࡀ⣽⬊⛣ື࠾ࡼࡧᙧែ࡟ཬࡰࡍᙳ㡪۵୎ 䴢▄ 1㸪ᮌᮧ ᰤ㍤ 1㸪᥃ᒣ ṇᚰ 1, 2㸪㐲ᒣ ༓᫓ 1㸦1 ᮾி኱㝔࣭་㸪2 㛗ᓮ኱㝔࣭་㸧ෆศἪ᧠஘໬Ꮫ≀㉁

P-21ࢲ࢖࢜࢟ࢩࣥࡢ⫾ඣᮇ᭚㟢࡟ࡼࡿฟ⏕ඣⓎ⫱㞀ᐖࡢ᪂つᶵᵓ㸸࿘⏘ᮇඣࡢᡂ㛗࣍ࣝࣔࣥపୗ࡟╔┠ࡋࡓゎᯒ۵᭹㒊཭⣖Ꮚ㸪Ṋ⏣▱㉳㸪⸨஭⨾ᙬ⣖ఀ㇋ᮏ࿴㤶㸪▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱㝔࣭⸆㸧P-22ࢲ࢖࢜࢟ࢩࣥ࡟ࡼࡿ⫱ඣᮇẕయࡢࣉࣟࣛࢡࢳࣥపୗ࡜ᶵᵓ࠾ࡼࡧඣࡢᡂ⇍࡬ࡢᙳ㡪۵ఀ㇋ᮏ࿴㤶㸪Ṋ⏣▱㉳㸪⸨஭⨾ᙬ⣖㸪᭹㒊཭⣖Ꮚ▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱࣭⸆㸧

P-23ࢲ࢖࢜࢟ࢩࣥẕయ᭚㟢࡟ࡼࡿඣࡢࢦࢼࢻࢺࣟࣆࣥᨺฟ࣍ࣝࣔࣥపୗࡢᐃ╔ᶵᵓ㸸࣓ࢱ࣑࣎ࣟࢡࢫ࡟ࡼࡿゎᯒ۵す⏣ᜤᏊ㸪Ṋ⏣▱㉳㸪▼஭♸ḟ㸪ᒣ⏣ⱥஅ㸦஑ᕞ኱࣭⸆㸧



P-24

ࢲ࢖࢜࢟ࢩࣥ࡟ࡼࡿ⫾ඣ࣭ᛶࢫࢸࣟ࢖ࢻྜᡂ㞀ᐖࡢᶵᵓ㸸࢚ࢿࣝࢠ࣮⏘⏕⣔࡟╔┠ࡋࡓゎᯒ۵ᯇᑿ཭ᶞ 㸪⸨ᮌ❶ኸ 㸪ྂ㈡㈗அ 㸪Ṋ⏣▱㉳ 㸪▼஭♸ḟ 㸪ᒣ⏣ⱥஅ ஑ᕞ኱㝔࣭⸆㸪 ⌧࣭➨୍⸆኱ 

P-25

Ah(ࢲ࢖࢜࢟ࢩࣥ)ࣞࢭࣉࢱ࣮ࡣ⬡⫫⤌⧊࡟࠾ࡅࡿ⫧‶౫Ꮡᛶࡢ⅖⑕ㄏⓎࢆ௓ࡋ࡚⢾ᒀ⑓Ⓨ⑕࡟㛵୚ࡍࡿ۵➟಴⏤㈗㸪࿴⏣ᖹ㸪ᴵⴥ⦾⣖㸦᪥ᮏ኱࣭⸆㸧



P-26

࣏࣮ࣞࢱ࣮࢔ࢵࢭ࢖⣔ࢆ⏝࠸ࡓ㤶⢝ရ㤶ᩱ࡟ࡼࡿ PXR, CAR㸪PPARȘ࠾ࡼࡧAhR άᛶࡢホ౯۵Ώ㒊ᐜᏊ 㸪ᑠᓥᘯᖾ 㸪ᾆ୸┤ே 㸪⸨ᮏᡂ᫂ 㸪ᮡཎᩘ⨾ 㸪ྜྷᡂᾈ୍ 㸪ኴ⏣ⱱ 㸪໭ᮧ⦾ᖾ 㸦 ᪥⸆኱㸪 ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸪 ໭ᾏ㐨⾨◊㸪 ᗈᓥ኱࣭ཎ་◊㸪 ᗈᓥᅜ㝿኱࣭⸆㸪 㟼ᒸ┴኱࣭⸆㸪 ᮾ໭኱㝔࣭⸆㸧

P-27᰾ෆཷᐜయ PXR ࠾ࡼࡧ CAR ㌿෗άᛶ࡟ᑐࡍࡿ⏥≧⭢࣍ࣝࣔࣥᵓ㐀㢮ఝ≀㉁ࡢᙳ
㡪۵ΎỈⰋ 㸪Ώ㒊ᐜᏊ 㸪ᾆ୸┤ே 㸪ᑠᓥᘯᖾ 㸪Ṋෆఙ἞ 㸪㯮ᮌᗈ᫂ 㸪ኴ⏣ⱱ 㸪໭ᮧ⦾ᖾ 㸪ᮡཎᩘ⨾ 㸦 ᗈᓥᅜ㝿኱࣭⸆㸪 ᪥ᮏ⸆኱㸪 ໭ᾏ㐨⾨◊㸪➨୍⸆኱㸪 ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸧

−32−

P-28

⸆≀௦ㅰ㓝⣲ aldehyde oxidase ࡢ࣐࢘ࢫ⫢࡛ࡢᛶᕪⓎ⌧࡜໬Ꮫ≀㉁ࡢᙳ㡪۵ᮡཎᩘ⨾ ᒸᔘ᫂✑ ⛅ᮏ᭷ⰼ ⏣ᒣ๛ᓫ ๓⏣ᚿὠᏊ బ⬟ṇ๛ ໭ᮧ⦾ᖾ ኴ⏣ⱱ 㸦 ᗈᓥᅜ㝿኱࣭⸆ ᗈᓥ኱㝔࣭་ṑ⸆ಖ೺Ꮫ◊✲⛉ ᪥ᮏ⸆⛉
኱㸧

P-29

⎔ቃ໬Ꮫ≀㉁࡟࠾ࡅࡿ࢚࢝ࣝ⏥≧⭢࣍ࣝࣔࣥస⏝ࡢ࢔ࢦࢽࢫࢺ࠾ࡼࡧ࢔ࣥࢱࢦࢽ
ࢫࢺάᛶ۵బ⬟ṇ๛㸯㸪୰ᮧ┤ᶞ㸯㸪㕥ᮌ㈼୍㸰㸪᯽ᮌၨᏊ㸱㸪ⰼ⏣⚽ᶞ㸱㸪ᒣᮏ༟㸰㸪᪂ᾏṇ㸲㸪ᮡཎᩘ⨾㸳㸪⸨ᮏᡂ᫂㸴㸪໭ᮧ⦾ᖾ㸵㸪᯽ᮌ᫛ᙪ㸰㸪ኴ⏣ ⱱ㸯㸦㸯ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸪㸰ᗈᓥ኱㝔࣭⌮࣭ᩘ⌮ศᏊ⏕࿨⌮Ꮫ㸪㸱ᗈᓥ኱㝔࣭⌮࣭୧⏕㢮◊✲᪋タ㸪㸲Ⱚᾆᕤ኱࣭ࢩࢫࢸ࣒⌮ᕤ㸪㸳ᗈᓥᅜ㝿኱࣭⸆㸪㸴ᗈᓥ኱࣭ཎ་◊㸪㸵᪥ᮏ⸆⛉኱Ꮫ㸧

P-30᪂ୡ௦ࣅࢫࣇ࢙ࣀ࣮ࣝ(ࣅࢫࣇ࢙ࣀ࣮ࣝ AF)࡟ࡼࡿ ERșࢆ௓ࡋࡓࢩࢢࢼࣝẘᛶ۵ᚨᏳ ⨾⣖ 1, ᒸᓮ ⿱அ 1, ụ⏣ ᜨ⌮Ꮚ 1, ▼஭ ᏹᖾ 1, ᇉῧ ࿴ᘯ 1, ጲ㔝 ኴ୍ 1,㇂ཱྀ ᙬ 1, ྜྷᒸ 㟹ྐ 1, ➉⏣ ಟ୕ 2, ཎཱྀ ᾈ୍ 1, Ώ㎶ ࿴ே 3, ℧ཱྀ ┈ྐ 2,Ⲩ∾ ᘯ⠊ 1 (1 ➨୍⸆኱, 2 ᗈᓥᅜ㝿኱࣭⸆, 3 ໭㝣኱࣭⸆)P-31኱㯞୺ᡂศǼ9-THC ࡟ࡼࡿᏊᐑᶵ⬟㞀ᐖ: ERȘᶵ⬟◚⥢࡜⣽⬊እ࣐ࢺࣜࢵࢡࢫศ
ゎ㓝⣲ࡢⓎ⌧ㄏᑟጲ㔝ኴ୍1۵ᒸᓮ ⿱அ 1, ụ⏣ ᜨ⌮Ꮚ 1, ᇉῧ ࿴ᘯ 1, ྜྷᒸ 㟹ྐ 1, ᚨᏳ ⨾⣖ 1㸪
㇂ཱྀ ᙬ 1㸪▼஭ ᏹᖾ 1, ➉⏣ ಟ୕ 2, Ώ㎶ ࿴ே 3, Ⲩ∾ ᘯ⠊ 1 (1 ➨୍⸆኱, 2 ᗈᓥᅜ㝿኱࣭⸆, 3 ໭㝣኱࣭⸆)



㣗ရ࡜㎰⸆

P-32

ࣜ࢞ࣥࢻࢆ௓ࡋࡓ AhR άᛶ໬࡟ཬࡰࡍ࣋ࣥࢬ࢖࣑ࢲࢰ࣮ࣝ㢮ࡢ」ྜᙳ㡪۵㛗⃝⪷Ꮚ㸯㸪㛵ᮏᚁྐ㸯㸪⏣ᓮឡె㸯㸪すᕝ⛅ె 㸪ᱵᮧ㝯ᚿ 㸪᰿ᮏΎග㸯㸪ྜྷᡂᾈ୍㸯㸪ฟᕝ㞞㑥㸯㸦㸯㟼ᒸ┴❧኱࣭⸆࣭⾨⏕ศᏊẘᛶᏛ㸪㸰ᅜ❧⾨◊㸧P-33ࣅࢱ࣑ࣥ K ኚ᥮㓝⣲ࡢⓎ⌧ไᚚᶵᵓ࡟㛵ࡍࡿ◊✲‫ۑ‬ᘅ⏣ ెஂ 1,2㸪୰ᕝ බᜨ 2㸪Ώ㎶ 㞞ே 2㸪⯚ᶫ ఙ᫛ 2㸪ᒸ㔝 Ⓩᚿኵ 2㸦1 㕥㮵་⒪኱⸆࣭⾨⏕⸆Ꮫ㸪2 ⚄ᡞ⸆኱࣭⾨⏕໬Ꮫ㸧P-34࢔ࣥࢻࣟࢤࣥ౫Ꮡᛶ㌿෗άᛶ໬࡟ཬࡰࡍⲔ࢝ࢸ࢟ࣥࡢᙳ㡪۵┾⏣ἲᏊ㸪Ḉ஭ᕼ㸪⸨஭భᐇ㸪ᮌୗ⏤ె㸪ᮌὠⰋ୍㸦ྠᚿ♫ዪᏊ኱࣭⸆㸧

P-35㖟ᮥ୰ẘᝈ⪅࡟࠾ࡅࡿᒀ୰ 4͛
-O-Methylpyridoxine ࠾ࡼࡧ௦ㅰ≀ࡢศᯒ۵▼ᕝ ⨾㤶㸪㧘ᶫ ᭸ె㸪ᑠᯘ ኱♸㸪ྜྷᮧ ᫛Ẏ㸪࿴⏣ ၨ∞㸦໭་⒪኱࣭⸆㸧



P-36

ࢼࣀࢡࣞ࢖ࡢᏳ඲ᛶ࡟㛵ࡍࡿ◊✲۵Ọ⏣㝯ኴ㑻㸪☾⏣຾ᗈ㸪኱ሯᮥ⳯㸪㛗㇂ᕝ▱ஓ㸪▼⏣ຌ㸦ᖇிᖹᡂ኱࣭⸆㸧

P-37

ࣛࢵࢺ in vivo ཬࡧ in vitro ࡛ࡢࣛࢬ࣮࣋ࣜࢣࢺࣥࡢࣟࢻࢹࣀ࣮ࣝ࡬ࡢ㑏ඖ۵ᆏᮏె⃈㸪Ώ㒊ᐜᏊ㸪ᾆ୸┤ே໭ᮧ⦾ᖾ㸦᪥ᮏ⸆኱㸧





−33−

P-38

HepG2 ⣽⬊࡟࠾ࡅࡿ Coriandrum sativum L. ⴥᢳฟᾮ୰ࡢ⬡⫫᪘ぶ㟁Ꮚ≀㉁࡟
ࡼࡿ↓ᶵ୕౯ࣄ⣲⣽⬊ẘᛶࡢ㍍ῶ
۵ᏳᏞᏊ࣑ࣘ㸯㸪⁁Ἑ┿⾰ 㸪⇃㇂჆ே 㸦㸯⟃Ἴ኱࣭་Ꮫ་⒪⣔㸪㸰⟃Ἴ኱㝔࣭⏕࿨⎔ቃ⛉Ꮫ㸧㔠ᒓP-39Ỉ㖟ࢺࣛࣥࢫ࣏࣮ࢱ࣮ࡢỈ㖟໬ྜ≀࡟ᑐࡍࡿᶵ⬟ゎᯒ۵᭮᰿᭷㤶㸪୰ᮧு௓㸪㧗᰿ἑᗣ୍Ύ㔝ṇᏊ㸦໭㔛኱࣭⸆㸧

P-40

Caco-2 ⣽⬊ࢆ⏝࠸ࡓࢧ࣏ࢽࣥ࡟ࡼࡿᢠ࣓ࢳࣝỈ㖟࡟㛵ࡍࡿ◊✲۵୰ᮧ ு௓㸪᭮᰿ ᭷㤶㸪㧗᰿ἑ ᗣ୍㸪ⓑ⏿ ㎮ᘺ㸪ᑠᯘ ⩏඾㸪Ύ㔝 ṇᏊ㸦໭㔛
኱࣭⸆㸧

P-41

Ỉ㖟࡜ࢭࣞࣀࢩ࢔ࣥ㓟ࡲࡓࡣளࢭࣞࣥ㓟ࢆᢞ୚ࡋࡓࣛࢵࢺ࡟࠾ࡅࡿỈ㖟࡜ࢭࣞࣥࡢయෆศᕸ۵ෆ⏣ ⱸⳀ㸪໭㔛 Ṍክ㸪㜿༡ ᘺᑑ⨾㸪ᑠ᳚ ᗣග㸦᫛࿴⸆኱㸧P-42ᇵ㣴⣽⬊࡟࠾ࡅࡿࢭࣞࣥ໬ྜ≀࡟ࡼࡿ↓ᶵỈ㖟ࡢẘᛶ㍍ῶస⏝ࡢゎᯒ۵☄஭ ⪽⨾㸪㜿༡ ᘺᑑ⨾㸪ᑠ᳚ ᗣග㸦᫛࿴⸆኱㸧P-43࣓ࢳࣝỈ㖟࡟᭚㟢ࡋࡓᇵ㣴ࣄࢺ⬻ᚤᑠ⾑⟶࿘⓶⣽⬊࡟࠾ࡅࡿ࢔ࣝࢻ࣮ࢫ㑏ඖ㓝⣲ࡢⓎ⌧ㄏᑟ۵➲ᒸᬛᏊ㸯㸪ྜྷ⏣ᫎᏊ㸯㸪ᒣᮏ༓ኟ㸰㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭
⸆㸧

P-44

࣓ࢳࣝỈ㖟࡟ࡼࡿᇵ㣴ࣄࢺ⬻ᚤᑠ⾑⟶࿘⓶⣽⬊ࡢ VEGF Ⓨ⌧ㄏᑟ࣓࢝ࢽࢬ࣒
۵Ḉ஭ ೺ኴ㸯㸪ྜྷ⏣ ᫎᏊ㸯㸪ᒣᮏ ༓ኟ㸰㸪㘬෬ ฼ᖾ 1㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭
⸆㸧

P-45

ᇵ㣴ࣄࢺ⬻ᚤᑠ⾑⟶ෆ⓶⣽⬊ࡢ⥺⁐⣔࡟ᑐࡍࡿ࣓ࢳࣝỈ㖟ࡢẘᛶⓎ⌧۵⏣୰⨾ᕹ㸯㸪ᰩ⏣㈼㸯㸪ྜྷ⏣ᫎᏊ㸯㸪ᒣᮏ༓ኟ㸰㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭⸆㸧P-46࣓ࢳࣝỈ㖟ࡢዷፎᮇ㣧Ỉ᭚㟢ࡀ⫾ඣࡢ⬻ୗᆶయ㸪⏕Ṫ⭢࠾ࡼࡧ๪⭈ࡢ࣍ࣝࣔࣥⓎ⌧࡟ཬࡰࡍᙳ㡪۵Ṋ⏣ ▱㉳ 1㸪᭹㒊 ཭⣖Ꮚ 1㸪௬ᒇⷵ ౡ኱ 1㸪⸨ᮧ ᡂ๛ 2㸪▼஭ ♸ḟ 1㸪ᒣ⏣ ⱥஅ 1㸦1 ஑ᕞ኱㝔࣭⸆, 2 ᅜỈ◊࣭ẘᛶ⑓ែ㸧

P-47࣓ࢳࣝỈ㖟࡟ࡼࡿ࣮࢜ࢺࣇ࢓ࢪ࣮ㄏᑟ࡟࠾ࡅࡿ LAMTOR 」ྜయࡢ㛵୚۵ᯇ⏣ ೺ே㸪㧗ᶫ ຮ㸪㯤 ᇶ᪫㸪Ọ἟ ❶㸦ᮾ໭኱࣭⸆㸧

P-48࣓ࢳࣝỈ㖟ᢞ୚࣐࢘ࢫࡢ⬻ᐊᣑ኱ࡢ MRI ࡟ࡼࡿ᳨ฟ
‫ۑ‬㧗ᶫுᖹ ఀ⸨ᗣ୍ ▼ཎᗣᏹ ᒣඖᜨ㸱㸪▼⏣ᩔᙪ ᒣᓮᓅ 㸦㸯ᗈᓥ኱࣭⥲㸪㸰ᚨᓥᩥ⌮኱࣭㤶ᕝ⸆㸪㸱Ỉಛ⑓⥲ྜ◊✲ࢭࣥࢱ࣮㸧



−34−

P-49

࢝ࢻ࣑࣒࢘᭚㟢 HK-2 ⣽⬊࡟࠾ࡅࡿ SGK1 Ⓨ⌧
۵ᐑᒣ㈗ග㸪ᯇᒸ㞞ே㸦ᮾிዪᏊ་኱࣭་㸧

P-50࢝ࢻ࣑࣒࢘ࡢෆ⓶⣽⬊ẘᛶ࡟ᑐࡍࡿள㖄ࡢ㜵ᚚᶵᵓ࡬ࡢ㔠ᒓ㍺㏦యⓎ⌧ࡢ㛵୚۵ୖཎⲁ㸯㸪ྜྷ⏣ᫎᏊ㸯㸪ᒣᮏ༓ኟ㸰㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭
⸆㸧

P-51

ࣜࣥࣃ⫗⭘⣽⬊ P1798 ࡬ࡢ࢝ࢻ࣑࣒࢘㛗ᮇฎ⌮࡟ࡼࡿ࣓ࢱࣟࢳ࢜ࢿ࢖ࣥㄏᑟ⬟ࡢኚ໬۵⚟ᮏ ෤㔛㸪ᮌᮧ ⰋᏱ㸪ಖᆏ ༟⮧㸪ᮌᮧ ᭸⣖㸦ᦤ༡኱࣭⸆㸧P-52࢝ࢻ࣑࣒࢘࡟ࡼࡿ⭈ẘᛶⓎ⌧࡟㛵୚ࡍࡿ㌿෗ᅉᏊࡢ⥙⨶ⓗゎᯒ۵ᚨᮏ ┿⣖㸪ᮤ ㎮❳㸪బ⸨ 㞞ᙪ㸦ឡ▱Ꮫ㝔኱࣭⸆㸧

P-53⃭ࡋ࠸㐠ື㈇Ⲵࡣ⤒ཱྀᦤྲྀ࢝ࢻ࣑࣒࢘ࡢయෆ⵳✚࡟ᑐࡍࡿࣜࢫࢡࣇ࢓ࢡࢱ࣮࡜࡞
ࡿ۵㛬ᗒၿ㸪ᕫ㰯⌮ᜨ㸪ゅṌ⨾㸪Ⲕཎຍዉ㸪ᒣ⏣ెኴ㸪ᆏᓮᩥಇ
㸦኱㜰኱㇂኱࣭⸆࣭⾨⏕ẘᛶᏛㅮᗙ㸧






P-54

࣐ࣥ࢞ࣥ⪏ᛶ⣽⬊࡟࠾ࡅࡿங㓟㛵㐃㑇ఏᏊࡢⓎ⌧ኚ໬۵⸨௦ ▖㸪ᇛ බᏊ㸪ጲ㔝 ㄔ୍㑻㸦ᚨᓥᩥ⌮኱࣭⸆㸧

P-55

ࢳ࢜-ࢪ࣓ࢳࣝ࢔ࣝࢩࣥ㓟࡟ࡼࡿศ⿣ᮇ⣽⬊ࡢ⵳✚࡟ᑐࡍࡿ BubR1 ࡢᙳ㡪۵௒஭ ඃ㸪໭ ຍ௦Ꮚ㸪㕥ᮌ ಇⱥ, ㉺ᬛ ᓫᩥ㸦ᖇி኱࣭⸆㸧

P-56ࢪࣇ࢙ࢽࣝ࢔ࣝࢩࣥ㓟ࡲࡓࡣࣄ㓟࡜ளࢭࣞࣥ㓟ࢆྠ᫬ᢞ୚ࡋࡓࣛࢵࢺ࡟࠾ࡅࡿࣄ
⣲࠾ࡼࡧࢭࣞࣥࡢయෆศᕸ࡜᤼ἥ۵ᑠᯘ ᘺ⏕㸪ᖹ㔝 㟹ྐ㑻㸦㸦⊂㸧ᅜ❧⎔ቃ◊✲ᡤ㸧

P-57㢮㔠ᒓࡢ࣓ࢳࣝ໬௦ㅰ࡟࠾ࡅࡿ As3MT ࡢ≉␗ᛶ۵຾⏣኱㈗㸪ᚫᮏ┿⣖㸪㜿༡ᘺᑑ⨾㸪ᑠ᳚ᗣග㸦᫛࿴⸆኱࣭⾨⏕໬Ꮫ㸧

P-58ࣛࢵࢺ࡟࠾ࡅࡿ↓ᶵཬࡧ᭷ᶵࢸࣝࣝ໬ྜ≀ࡢయෆศᕸࡢẚ㍑
۵ሯᮏ Ὀ௦㸪㜿༡ ᘺᑑ⨾㸪᪂ Ὀ௓㸪Ụᖭ ᰆ⾰, ᑠ᳚ ᗣග㸦᫛࿴⸆኱㸧P-59༸ᕢᶵ⬟࡟ࡼࡿ TPT ẘᛶⓎ⌧ಟ㣭۵኱ሯ భᇶ㸪㟷ᮌ ᫂㸪୰す ๛㸪Ọ℩ ஂග㸦ᒱ㜧⸆኱࣭⸆㸧

P-60

᭷ᶵࢫࢬ໬ྜ≀ࡢẘᛶⓎ⌧࡟ᑐࡍࡿ Major Urinary Protein1 ࡢᙳ㡪۵㟷ᮌ ᫂㸪኱ሯ భᇶ㸪୰す ๛㸪Ọ℩ ஂග㸦ᒱ㜧⸆኱㸧

P-61᭷ᶵࢫࢬ໬ྜ≀࡟ࡼࡿ IDH3 ࢆ௓ࡋࡓ G2/M ᮇ೵Ṇࡢ࣓࢝ࢽࢬ࣒
۵㯞ⷷ⨾⣖㸯ᒣ⏣ⱱ㸯ྂṊᘺ୍㑻 ᯈᇉᏹ 㛵㔝♸Ꮚ ㅋ⏣Ὀᡂ 㸦㸯ᅜ❧⾨◊࣭⸆⌮㸰ᶓᅜ኱㝔࣭ᶵ⬟Ⓨ⌧ ᗈᓥ኱㝔࣭་ṑ⸆ಖ㸧



−35−

P-62

㔜㔠ᒓࡀ MMP2 ࠾ࡼࡧ MMP9 άᛶ࡟୚࠼ࡿᙳ㡪۵す㇂ ඾Ꮚ㸪➉⏣ ಟ୕㸪℧ཱྀ ┈ྐ㸦ᗈᅜ኱࣭⸆㸧

P-63⢾໬཯ᛂ୰㛫య dihydropyrazine ࡟ࡼࡿள㖄㍺㏦ࢱࣥࣃࢡ㉁ࡢⓎ⌧ኚື۵ᑠᯘ ╬⨾㸪‶␃ ព୚㸪▼⏣ ༟ᕭ㸪Ṋ▱ 㐍ኈ㸦ᓫᇛ኱࣭⸆㸧

P-64

TGF-ș1 ࡟ࡼࡿ⾑⟶ෆ⓶⣽⬊ࡢள㖄㍺㏦య ZIP8 ࡢⓎ⌧ୖ᪼۵ୗᮧ ṇ⿱㸯㸪ྜྷ⏣ ᫎᏊ㸯㸪ᒣᮏ ༓ኟ㸰㸪㘬෬ ฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾ㑥኱࣭
⸆㸧

P-65

᭷ᶵࣅࢫ࣐ࢫ໬ྜ≀ࡢẘᛶⓎ⌧࡟㛵୚ࡍࡿ㑇ఏᏊࡢ᥈⣴۵୰ᾎ㟼㤶㸯㸪㒆ஂ⨾Ꮚ㸯㸪ᒣᮏ༓ኟ㸰㸱㸪Ᏻụಟஅ㸰㸲㸪㘬෬฼ᖾ㸯㸰㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᮾி⌮኱࣭⥲◊ %20㸪㸱ᮾ㑥኱࣭⸆㸪㸲ឡ▱Ꮫ㝔኱࣭⸆㸧P-66᭷ᶵ࢔ࣥࢳࣔࣥ໬ྜ≀ࢆ⏝࠸ࡓ⾑⟶ෆ⓶⣽⬊ࡢ࣓ࢱࣟࢳ࢜ࢿ࢖ࣥ㑇ఏᏊⓎ⌧ᶵᵓゎᯒ۵ᮧୖ ṇᶞ㸯㸪⸨Ụ ᬛஓ㸯㸪ᮌᮧ ᭸⣖㸰,㸱㸪⸨ཎ Ὀஅ㸱,㸲㸪Ᏻụ ಟஅ㸱,㸳㸪ᒣᮏ ༓ኟ㸱,㸴㸪㘬෬ ฼ᖾ㸯,㸱㸦㸯ᮾி⌮኱࣭⸆㸪㸰ᦤ༡኱࣭⸆㸪㸱ᮾி⌮኱⥲◊ BOM㸪㸲ᮾி⸆኱࣭⸆㸪㸳ឡ▱Ꮫ㝔኱࣭⸆㸪㸴ᮾ㑥኱࣭⸆㸧P-67⾑⟶ᖹ⁥➽⣽⬊࡟࠾࠸࡚ࣅࢢࣜ࢝ࣥྜᡂࢆ㑅ᢥⓗ࡟ㄏᑟࡍࡿ᭷ᶵ࢔ࣥࢳࣔࣥ໬ྜ
≀۵ᑠᯘ⍞✑ 㸪Ᏻụಟஅ 㸪㘬෬฼ᖾ 㸪ᒣᮏ༓ኟ 㸦㸯ᮾ㑥኱࣭⸆㸪㸰ឡ▱Ꮫ㝔኱࣭⸆㸪 ᮾி⌮኱࣭⸆㸧

P-68㖡㘒యࢆά⏝ࡋࡓ⾑⟶ෆ⓶⣽⬊ࡢ࣓ࢱࣟࢳ࢜ࢿ࢖ࣥㄏᑟᶵᵓࡢゎᯒ۵⸨Ụᬛஓ㸯㸪୰ᐶྐ 㸪⸨ཎὈஅ 㸪㘬෬฼ᖾ㸯㸦㸯ᮾி⌮኱࣭⸆㸪㸰ྡ኱࣭≀ᅜࢭ㸪 ᮾி⌮኱࣭⥲◊ BOM㸪 ᮾி⸆኱࣭⸆㸧

P-69⾑⟶ෆ⓶⣽⬊࡟࠾࠸࡚⥺⁐άᛶࢆไᚚࡍࡿள㖄㘒య۵୰ᕝⱸዉ⨾㸯㸪୰ᮧṊᾈ㸰㸪㘬෬฼ᖾ㸰㸪ᒣᮏ༓ኟ㸯㸦㸯ᮾ㑥኱࣭⸆㸪㸰ᮾி⌮
኱࣭⸆㸧

P-70

ྜᡂᾮయᇵᆅᇵ㣴⥺⹸࡟ࡼࡿ㖡㸪ள㖄ᛂ⟅㑇ఏᏊࡢ᥈⣴۵෠Ọఙ᫂㸯㸪᳧ᓥᮤṌ㸯㸪ᒣཱྀ᫂⨾㸯㸪ෆ⏣㞞ஓ㸰㸪᭷ⷵᖾྖ㸱㸦㸯᭷᫂㧗ᑓ࣭≀㉁ᕤ㸪㸰࢚ࢥࢪ࢙ࣀ࣑ࢡࢫ㸪㸱⇃ᮏ┴኱࣭⎔ቃඹ⏕㸧

P-71ࢳࢱࣥࢼࣀ⢏Ꮚ P25 ࡀ♧ࡍ⢭ᕢᶵ⬟㞀ᐖ۵୕ᾆ ఙᙪ㸪኱㇂ ຾ᕫ㸪㕥ᮌ ဴ▮㸪ᰗሙ ⏤⤮㸪໭ᲄ ⌮ᜨᏊ㸪㡲⏣ ᜨ㸪⋤ ⍞⏕㸦㸦⊂㸧ປാᏳ඲⾨⏕⥲ྜ◊✲ᡤ㸧

P-72࣑࢜࢜ࢪࣥࢥࢆ⏝࠸ࡓ 50 㔠ᒓࡢᛴᛶẘᛶヨ㦂۵ᒸᮏ ᬡ㸯㸪㛆㏕ ඾ஂ 1,2㸦㸯ᮾி኱㝔࣭᪂㡿ᇦ๰ᡂ⛉Ꮫ⛉㸪㸰ᅜ❧⎔ቃ◊✲ᡤ㸧



−36−

ච␿ẘᛶ࣭ឤᰁ⑕

P-73

ERK2 ࡟ࡼࡿ HIV ⬺Ẇ㐣⛬ࡢไᚚᶵᵓࡢゎ᫂࡜ HIV ឤᰁ⑕ඞ᭹࡟ྥࡅࡓᢠ HIV๣ࡢ᥈⣴۵ᇽᆅ ㉰⏕㸯㸪㧗᐀ ᬸᬡ 2㸪୕㝮 ᑗ࿃ 3㸦㸯⇃ᮏ኱࣭⸆࣭⎔ศಖ㸪㸰⇃ᮏ኱࣭KICO,
3⇃኱㝔࣭⏕⛉㸧

P-74ᐟ୺⣽⬊ࡣ HIV ㏫㌿෗཯ᛂ㛤ጞ㜼ᐖᅉᏊ࡜ࡋ࡚ GAPDH ࢆഛ࠼ᣢࡘ
۵ᓊᮏ┤ᶞ㸯㸪㨣ሯᙬ஀㸯㸪㧗᐀ᬸᬡ㸰㸪୕㝮ᑗ࿃ 㸦㸯⇃኱㝔࣭⸆㸪㸰⇃኱ .,&2㸪⇃኱㝔࣭⏕⛉㸧P-75

C ᆺ⫢⅖࢘࢖ࣝࢫ Core ࡢ⣽⬊㉁ෆศᕸࡀᑠ⬊యࢫࢺࣞࢫ࠾ࡼࡧἜ⁲ᙧᡂࡢㄏᑟ
࡟୚࠼ࡿᙳ㡪㸸㓝ẕࣔࢹࣝࢩࢫࢸ࣒ࢆ⏝࠸ࡓゎᯒ۵ᒾబ ┿࿃㸪ᒾ஭ ೺ኴ㸪ஂୗ ࿘బ㸦ᮾ໭⸆⛉኱࣭ᚤ⏕≀Ꮫᩍᐊ㸧

P-76

࣐࢘ࢫ᥋ゐᛶ㐣ᩄ཯ᛂࡢឤసẁ㝵࡟࠾ࡅࡿࢧ࢖ࢺ࢝࢖ࣥⓎ⌧㔞ࡢኚື۵ᆏᓮ ᩥಇ㸪⏣㑔 ୓ஓ㸪⚄ᓮ ⩧ኴ㸪ᒣ⏣ ెኴ㸪㛬 ᗒၿ㸦኱㜰኱㇂኱࣭⸆㸧

P-77࣐࢘ࢫ⭁⮚⣽⬊࠾ࡼࡧ⭡⭍࣐ࢡࣟࣇ࢓࣮ࢪ࡟ᑐࡍࡿ㓟໬࢜ࣜࣈἜࡢᙳ㡪۵Ⲷ㔝 Ὀྐ㸪༡ ឡ⾰㸪୰ᔱ 㝯ᏹ㸪ᒸ ኸᏊ㸪Ⲩᕝ ཭༤㸪ዟ㔝 ᬛྐ㸪ୖ㔝 ோ㸦ᦤ
༡኱࣭⸆㸧




㓟໬ࢫࢺࣞࢫ

P-78࣑ࢺࢥࣥࢻࣜ࢔㞀ᐖ࡟ࡼࡿ⣽⬊Ṛㄏᑟ࡟࠾ࡅࡿ mitSMase ࡢᶵ⬟ࡢゎᯒ۵⇃㇂ ๛㸪すᮧ ዉ⥴ᜨ㸪Ᏻ㒊 ᮃ⨾㸪㐲ᒣ ᜨⳀ㸪୰ᕝ 㟹୍㸪௒஭ ᾈᏕ (໭㔛
኱࣭⸆)

P-79

㐣㓟໬Ỉ⣲ẘᛶ㍍ῶ࡟㛵ࢃࡿ⩻ヂ㛤ጞᅉᏊ eIF5۵㧗ᶫ ຮ㸪⤃㔝 㞝స㸪ᮒ ಇ㌺㸪㯤 ᇶ᪫㸪Ọ἟ ❶㸦ᮾ໭኱㝔࣭⸆㸧

P-80࣓ࢱࣟࢳ࢜ࢿ࢖ࣥḞᦆ⬡⫫⣽⬊ࡢศ໬࡟ᑐࡍࡿᇵᆅ୰ phenol red ࡢᙳ㡪۵㕥ᮌ ┿ஓ㸪ᐑ஭ ⌮ຍ㸪㡢ᡂ ᑦྐ, ᳃ ࿴ಇ, బ㔝 ᬛஅ, 㛛⏣ ెே,ᕝୖ 㝯ⱱ㸦ᚨᓥᩥ⌮኱࣭⸆㸧P-81ᾏὒᛶ࢝ࣟࢸࣀ࢖ࢻ fucoxantin ࡜ fucoxantinol ࡢ Nrf2-ARE/HO-1 άᛶ໬స⏝۵♽⣡ඖ ⨾ᶞ㸪ୖཎ ṇႹ㸪ᖹⰋ ῟ㄔ㸦Ἀ⦖ᕤᴗ㧗➼ᑓ㛛Ꮫᰯ࣭⏕≀㈨※ᕤ㸧

P-82

Xanthohumol ࡟ࡼࡿ HO-1 ㄏᑟ࡟࠾ࡅࡿ AhR ࡢ㛵୚۵୰℈ 㝯அ㸪Ⳣ㔝 ⿱୍ᮁ㸪㟷ᮌ ⌮Ꮚ㸪ᆏᮏ ㈡௦㸪㧗ᶫ ᬛᐶ㸪∾㔝 㝧௓㸪஭ୖ ⩏㞝 㸦ᮾ㑥኱࣭⸆㸧

−37−

⣽⬊ᛂ⟅

P-83

άᛶ࢖࢜࢘ศᏊ࡜㓟໬ࢫࢺࣞࢫࢆ௓ࡋࡓ 1,2-ࢼࣇࢺ࢟ࣀࣥ࡟ࡼࡿぶ㟁Ꮚࢩࢢࢼࣝ
ࡢάᛶ໬۵᪂㛤Ὀᘯ 㸪୕ᾆ㧗 㸪᥃ᶫ⚽┤ 㸪㉥ụᏕ❶ 㸪⇃㇂჆ே 㸦 ⟃Ἴ኱࣭་㸪⟃Ἴ኱㝔࣭ே㛫⥲ྜ⛉Ꮫ㸪 ᮾ໭኱࣭་㸧

P-84࣐ࢡࣟࣇ࢓࣮ࢪ࡟ࡼࡿࣞࢭࣉࢱ࣮ࢱࣥࣃࢡ㉁ࢾࢡࣞ࢜ࣜࣥࢆ௓ࡋࡓኚᛶ LDL ࡢㄆ㆑‫ెⰼ❧ۑ‬ᘯ㸯኱‖♸ຍ㔛㸯୕ᮌ㞝୍㸯ᖹ㔝࿴ஓ㸰ูᗓṇᩄ㸯⸨ཎὈஅ㸯 㸯ᮾி⸆⛉኱࣭⸆㸪㸰㧗ᓮ೺ᗣ⚟♴኱࣭⸆ 




P-85

MC3T3-E1 ⣽⬊࡟࠾࠸࡚ࠊࣇ࢕ࢭࢳࣥࡣ LPS ࡟ࡼࡿ RANKL ࡢⓎ⌧ࡢୖ᪼ࢆᢚไࡍࡿ۵㜿㒊 ᝆ኱㸪᱒⏕ 㐨᫂㸪㔠ᮌ ᘯஅ㸪Ỉⴠ ⱱᶞ㸪஭ᡭ ㏿㞝㸪ᒣᮏ ༓ኟ㸦ᮾ㑥኱࣭
⸆㸧

P-86

PPARȘ࡟࢔ࢦࢽࢫࢺస⏝ࢆ♧ࡉ࡞࠸Ǽ9-ࢸࢺࣛࣄࢻࣟ࢝ࣥࢼࣅࣀ࣮ࣝ࡟ࡼࡿ
PPARȘࡢάᛶ໬࡜ไᚚୗ㑇ఏᏊ FA2H ࡢⓎ⌧ྜྷᒸ 㟹ྐ 1, ۵ụ⏣ ᜨ⌮Ꮚ 1, ➉⏣ ಟ୕ 2, ▼஭ ᏹᖾ 1, すᮧ ⫕ 1, Ώ㎶ ࿴ே 3,Ⲩ∾ ᘯ⠊ 1 (1 ➨୍⸆኱, 2 ᗈᓥᅜ㝿኱࣭⸆, 3 ໭㝣኱࣭⸆)

P-87࢔࣏ࢺ࣮ࢩࢫ㜼ᐖ๣࣎ࣥࢡࣞ࢟ࣥ㓟ࡢ᪂ࡓ࡞⏕≀άᛶ: PPARȚࡢ㑅ᢥⓗάᛶ໬๣࡜ࡋ࡚ࡢ᭷⏝ᛶ۵㇂ཱྀ ᙬ 1, ụ⏣ ᜨ⌮Ꮚ 1, ➉⏣ ಟ୕ 2, ᚨᏳ ⨾⣖ 1, ▼஭ ᏹᖾ 1, ྜྷᒸ 㟹ྐ 1,
すᮧ ⫕ 1, ᒸᓮ ⿱அ 1, ᯇᮏ ೺ྖ 3, ᪂⸨ ඘ 3, Ⲩ∾ ᘯ⠊ 1 (1 ➨୍⸆኱, 2 ᗈᓥᅜ㝿኱࣭⸆, 3 ஑ᕞ኱࣭ඛᑟ◊)P-88యෆ᫬ィ࡟ࡼࡿ⫹Ồ㓟ࡢゎẘ࠾ࡼࡧ᤼ἥᶵᵓࡢไᚚ
۵ྜྷ⏣ ㈼᪂㸪࿴⏣ ᖹ㸪ᴵⴥ ⦾⣖㸦᪥ᮏ኱࣭⸆㸧

P-89

Saururus chinensis ⏤᮶ࡢάᛶᡂศ࡟ࡼࡿ STAT3 ࢩࢢࢼࣝࢆ௓ࡋࡓࡀࢇᖿ⣽⬊




ᢚไస⏝
۵ᒣୗ┤ဢ㸯㸪Ⳣ㔝⿱୍ᮁ㸯㸪బ⸨ࡕࡦࢁ㸯㸪ⱝ஭ᑗᚿ㸰㸪㐲⸨ៅᖹ㸰㸪ᮤᕒ㸯㸪ᑠụ୍⏨㸯㸪ὸ⏣ၿஂ㸰㸪஭ୖ⩏㞝㸯㸦㸯ᮾ㑥኱࣭⸆㸪㸰ᮾ⌮኱࣭⸆㸧P-90㠀᥋╔ᇵ㣴࡟ࡼࡿ๓❧⭢ࡀࢇ⣽⬊ࡢࢫࣇ࢙ࣟ࢖ࢻᙧᡂ࡟࠾ࡅࡿ AhR ࡢᙺ๭۵Ṋ㐨 ᾴᖹ㸪Ⳣ㔝 ⿱୍ᮁ㸪஭ୖ ⩏㞝㸦ᮾ㑥኱࣭⸆㸧P-91ࢭࣞࣥ࡟ࡼࡿࣄࢺ⫵⒴⏤᮶⣽⬊ࡢቑṪᢚไ࡜ࢭࣞࣀࣉࣟࢸ࢖ࣥⓎ⌧࡜ࡢ㛵㐃ᛶ۵ዟ㔝ᬛྐ㸪໭ᇉள⏤⨾㸪ᮏከ ⤮᲍㸪㔝ᮧᘺ⣖㸪Ⲷ㔝Ὀྐ㸪Ⲩᕝ཭༤㸪ୖ㔝ோ㸦ᦤ༡኱࣭⸆㸧

P-92࣐ࢡࣟࣇ࢓࣮ࢪࡢ⅖⑕ᛶ࣓ࢹ࢕࢚࣮ࢱ࣮Ⓨ⌧࡟ᑐࡍࡿࢭࣞࣀ࣓ࢳ࢜ࢽࣥࡢᙳ㡪۵Ⲩᕝ ཭༤㸪ᒸ⏣ ┾⏤Ꮚ㸪Ⲷ㔝 Ὀྐ㸪ዟ㔝 ᬛྐ㸪ୖ㔝 ோ㸦ᦤ༡኱࣭⸆㸧

−38−

P-93

᰾ෆཷᐜయ CAR ࡜ PRMT5 ࡢ┦஫స⏝۵Ⳣ㔝 ⿱୍ᮁ, ධෆᓥ ₶, ຍ⸨ ࡉࡸ࠿, ᚨඖ ༓㤶Ꮚ, ࿋ ⏤㈗, ஭ୖ ⩏㞝㸦ᮾ㑥
኱࣭⸆㸧

P-94

Euphrobia fischeriana ᢳฟᡂศ࡟ࡼࡿ ERȘ, ș, PXR ࢔ࢦࢽࢫࢺస⏝۵㇂ὠ ᬛྐ㸪Ⳣ㔝 ⿱୍ᮁ㸪ᮃ᭶ ࡳࡕࡿ, ໷ ⸄➉, ᮤ ᕒ, ᑠụ ୍⏨, ஭ୖ ⩏㞝㸦ᮾ㑥኱㝔࣭⸆㸧

P-95

DNA ௜ຍయᙧᡂ࡟ࡼࡿ࣐࢘ࢫ⬇ᛶᖿ⣽⬊ࡢከศ໬⬟႙ኻ࡜࢔࣏ࢺ࣮ࢩࢫࡢㄏᑟ
۵ⱝཎ⨾Ἃ⣖㸯㸪ᡞ㑔㝯ኵ㸯㸪⸨ᮧᑗ኱㸯㸪ᐊ༤ஓ㸯㸪ᒸᮏ㄃ኈ඾㸯㸪᳜⏣ᗣḟ㸯㸪㧗⏣㐩அ㸰㸪ᑠᔱ௰ኵ㸯㸦㸯ྡᇛ኱࣭⸆㸪㸰❧࿨㤋኱࣭⸆㸧P-96⣸እ⥺᭚㟢࡟ࡼࡿ࣐࢘ࢫ⬇ᛶᖿ⣽⬊ࡢ p53 㠀౫Ꮡⓗ⣽⬊Ṛ۵ΎỈඃᕼ㸯㸪ᡞ㑔㝯ኵ㸯㸪ᒸᮏ㄃ኈ඾㸯㸪᳜⏣ᗣḟ㸯㸪㧗⏣㐩அ㸰㸪ᑠᔱ௰ኵ㸯㸦㸯ྡᇛ኱࣭⸆㸪㸰❧࿨㤋኱࣭⸆㸧P-97ప⃰ᗘ᭷ᶵࢫࢬ࡟ࡼࡿᑠ⬊యࢫࢺࣞࢫᛂ⟅㠀౫Ꮡⓗ࡞ eIF2 άᛶ໬۵ቑ⏣ᜤ୍㸯㸪ྂṊᘺ୍㑻 㸪☾ᮧ⥳ ᒸᮧ▱㤶 ኴ⏣ⱱ 㸦㸯ᗈᓥ኱࣭⸆㸪㸰ᗈᓥ኱㝔་ṑ⸆ಖ㸧

P-98

TGF-șࢩࢢࢼࣝไᚚᅉᏊ࡜ࡋ࡚ࡢࢩ࣮ࣗࢻ࢟ࢼ࣮ࢮ TRB1 ࡢᶵ⬟۵⃝୰ ⨾ᕼ㸪ఀ⸨ ཭㤶㸪஭ୖ 㟹㐨㸪ᯘ ⚽ᩄ㸦ྡྂᒇᕷ኱㝔࣭⸆㸧




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⏕໬Ꮫ

P-99

ࢥࣞࢫࢸ࣮ࣟࣝࢺࣛࣥࢫ࣏࣮ࢱ࣮NPC1L1 ࡟ࡼࡿȘ-ࢺࢥࣇ࢙࣮ࣟࣝࡢ⣽⬊ෆྲྀࡾ㎸ࡳ۵ୖᩜ㡿 ῟㸪ཎཱྀ ⨾ဏ㸪䬞ཎ ᗈᜨ㸪ᯇᮏ ┤ஓ㸪ᮡཎ ᡂ⨾㸦⚟ᒣ኱࣭⸆㸧

P-100LXRȘ࡟ࡼࡿ⫢⬡⫫⵳✚ࢩࢢࢼࣝ࡟࠾ࡅࡿ PPARȚࡢ㛵୚۵⸛ཎ ኱⏠㸯㸪ᯇᮎ බᙪ㸯㸪ᯇᑿ ᗣᖹ㸯㸪℧ཱྀ ⥲୍㸰㸪ᒣ㔝 ⱱ㸯㸦㸯⚟ᒸ኱࣭⸆㸪㸰஑ᕞࡀࢇࢭࣥࢱ࣮⮫ᗋ◊✲㒊㸧

P-101

PXR άᛶ໬ࡣቑṪᅉᏊ౫Ꮡⓗ࡞⫢⣽⬊ቑṪࢆಁ㐍ࡍࡿ۵㜿㒊ኴ⣖㸯㸪ᚿὠ ᛭ኴ㸯㸪ᯇἑཌ ྜྷᡂᾈ୍ 㸦㸯ᮾ໭኱㝔࣭⸆㸪㸰㟼ᒸ┴❧኱࣭⸆㸧

P-102࣐ࢡࣟࣇ࢓࣮ࢪ⾲㠃ࣞࢭࣉࢱ࣮ࢾࢡࣞ࢜ࣜࣥࢆ௓ࡋࡓ࣐ࣞ࢖ࣝ໬ BSA ࡢㄆ㆑۵ᑠᒣె♸㸯㸪᮶ᰨⰼዉ㸯㸪୕ᮌ㞝୍ 㸪ᖹ㔝࿴ஓ㸰㸪ูᗓṇᩄ 㸪⸨ཎὈஅ 㸦㸯ᮾி⸆኱࣭⸆㸪㸰㧗ᓮ೺ᗣ⚟♴኱࣭⸆㸧


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P-103

ࣉࣟࢫࢱࢢࣛࣥࢪࣥ᭱⤊ྜᡂ㓝⣲ࡢ⬡⫫⵳✚࡬ࡢ㛵୚۵బࠎᮌ⏤㤶㸯㸪ᒣᕝ཭⌮㸯㸪㉥ὠⴌ㸯㸪ᶓᒣ▱ỌᏊ㸰㸪ཎಇኴ㑻㸯㸦㸯᫛࿴኱࣭⸆㸪㸰⚄ዉᕝᕤ⛉኱㸧

−39−

P-104⾑⟶ᖹ⁥➽⣽⬊࡟࠾ࡅࡿ㌿෗ᅉᏊ YY1-Rb ࡢ⏕໬Ꮫⓗゎᯒ۵ᘅᮧಙ㸯㸪ᒣඖ㄃Ꮚ 㸪ྂ㈡ ㈗அ ᳃ᒣᓠ༤ $QQ\8VKHYDᡞ⏣ ᬗஂ 㸦㸯➨୍⸆኱࣭⾨⏕໬Ꮫ㸪㸰➨୍⸆኱࣭⸆≀἞⒪ ➨୍⸆኱࣭⫱⸆ࢭࣥࢱ࣮㸪 ࣁ࣮ࣂ࣮ࢻ኱࣭་㸧P-105ࣅࢢࣜ࢝ࣥࡣTGF-ș1 ࡜༠ㄪࡋ࡚ALK5 ⤒㊰ࢆ௓ࡋࢩࣥࢹ࢝ࣥ-4 ࡢⓎ⌧ࢆᢚไࡍࡿ۵ཎ ᓫே㸪㘬෬ ฼ᖾ㸦ᮾி⌮኱࣭⸆㸧P-106㛗㙐࢔ࢩࣝ CoA ྜᡂ㓝⣲ࡢ㜼ᐖ࡟ࡼࡿ⬡⫫㓟௦ㅰኚືࡢゎᯒ۵᱓⏣ ᾈ㸪ᓥ⏣ ᾈ᫂㸪ᗉྖ ▱⣫㸪⚟ᓥ ᭷ᙬ㸪ཎ ಇኴ㑻㸦᫛࿴኱࣭⸆㸧

P-107

BMP ࢔ࣥࢱࢦࢽࢫࢺ gremlin 㑇ఏᏊࡢⓎ⌧ㄪ⠇‫ ⏣⏫ۑ‬ᑦ⣖㸪す⏣ 㤶⧊㸪୕㡲 ᆂ⧊㸪Ἠ 㞝௓㸪Ỉⴠ ⱱᶞ㸪㔠ᮌ ᘯஅ㸪஭ᡭ ㏿㞝㸪ᒣᮏ ༓ኟ㸦ᮾ㑥኱࣭⸆㸧P-108㦵ⱆ⣽⬊ᶵ⬟ࢆᢚไࡍࡿ E3 ࣘࣅ࢟ࢳ࣮ࣥࣜ࢞ࢮ Smurf ࡢⓎ⌧ࡣຍ㱋࡟క࠸ୖ᪼ࡍࡿ۵㓇஭ 㤶⳯Ꮚ㸪㔠ᮌ ᘯஅ㸪㈅ሯ ᭸ᜨ㸪᱒⏕ 㐨᫂㸪Ỉⴠ ⱱᶞ㸪஭ᡭ ㏿㞝㸪ᒣᮏ ༓ኟ㸦ᮾ㑥኱࣭⸆㸧

P-109ࣈࢱ࡟࠾ࡅࡿ⾑୰ࢸࢫࢺࢫࢸࣟࣥ㔞ࡢရ✀㛫ᕪ㸸⢭ᕢࡢࢸࢫࢺࢫࢸࣟࣥ⏘⏕㛵㐃㑇ఏᏊⓎ⌧ࢆᣦᶆ࡜ࡋࡓゎᯒ۵ᑠᓥ⨾ဏ㸯㸪㡲⸨῟୍㸯㸪ฟᕝ㞞㑥㸰㸦㸯㎰ᴗ⏕≀㈨※◊㸪㸰㟼ᒸ┴኱࣭⸆㸧



P-110

ࣅࢱ࣑ࣥ D ཷᐜయ㑇ఏᏊḞᦆ࣐࢘ࢫࡢᛶᶵ⬟ࡢゎᯒ۵㙊ᑿ ࡲࡸ㸪ኴ⏣ 㯞⾰Ꮚ㸪஬༑ᔒ 㐶㤶㸪⏣୰ ༓✀㸪す ᬗᏊ㸪すᮧ ຍዉ⨾㸪ᯘ ឡ⳹㸪ᒸ㔝 Ⓩᚿኵ㸦⚄ᡞ⸆኱࣭⸆㸧

P-111

㔜㔠ᒓ౫Ꮡᛶ㌿෗ᅉᏊ MTF-1 ࡢከᶵ⬟ᛶ Zinc-finger ࡟ࡘ࠸࡚۵ୗᒣከᫎ㸯㸪㛗⏣ὒ୍㸯㸪㕥ᮌ⸅㸰㸪ᑠἨಙ⁠ 㸪኱ሯᩥᚨ㸯㸦㸯ᖇி኱࣭⸆㸪
㸰
Ᏻ⾨◊㸧

P-112

㣗஦ㄏᑟᛶ⫧‶࡟ࡼࡿ〓Ⰽ⬡⫫⤌⧊ࡢࢣࢺࣥయ฼⏝⤒㊰࡬ࡢᙳ㡪ࡢ᳨ウ۵ᒣᓮṇ༤ 㸪ᑿᓮṇኴ㑻 㸪໭ᮧ្ 㛗㇂ᕝ᫴ஓ ⚟஭ဴஓ 㸦 ᫍ⸆኱࣭⸆㸪 ❧࿨㤋࣭⸆㸧

P-113⚄⤒⣽⬊ࡢศ໬㐣⛬࡟࠾ࡅࡿࢣࢺࣥయ฼⏝㓝⣲ࡢᙺ๭۵㛗㇂ᕝ᫴ஓ㸯㸪⚟஭ဴஓ㸰㸪ᒣ㷂ṇ༤㸯㸦㸯ᫍ⸆኱࣭⸆㸪㸰❧࿨㤋኱࣭⸆㸧



ண㜵⸆Ꮫ

P-114

ࣞࢳࣀ࢖ࢻㄏᑟయ࡟ࡼࡿࡀࢇ⣽⬊ᾐ₶ᢚไᶵᵓ۵௒஭ ṇᙪ㸪Ṋ⏣ ⪔ኴ㑻㸪ᮤ ᕝ㸪㧗ᶫ ඾Ꮚ (ᫍ⸆኱࣭་⸆◊࣭⑓ែᶵ⬟ไᚚᏛ)−40−

P-115⫧‶࡟ཬࡰࡍ Momordica charantia extract ࡢᙳ㡪۵✑ᆏ ᵞᏊ㸪⇃ᒸ 㝯ஓ㸪௒஭ ṇᙪ㸪㧗ᶫ ඾Ꮚ㸦ᫍ⸆኱࣭་⸆◊࣭⑓ែᶵ⬟ไᚚ
Ꮫ㸧

P-116

ࢳࣟࢩࢼ࣮ࢮάᛶ㜼ᐖ๣ࡢ᥈⣴۵㧗ᶫ ඾Ꮚ㸪௒஭ ṇᙪ㸪ᑠ᳃ ᝆ (ᫍ⸆኱࣭་⸆◊࣭⑓ែᶵ⬟ไᚚᏛ)

P-117ኚ␗࣭ࡀࢇཎᛶ≀㉁ 1-nitropyrene ࡟ᑐࡍࡿ⥳Ⲕ୰ࡢᢠ㑇ఏẘᛶ≀㉁ࡢ᳨⣴۵㛗㇂஭ ཭ᑜ㸪⸨ᶫ ឡ㸪᪂㛤 ྐᓫ㸪Ἑྜ భᏘ㸪Ώ㎶ ᚭᚿ㸦ி㒔⸆኱㸧

P-118࢚ࢫࢺࣟࢤࣥཷᐜయ࡟౫Ꮡࡋࡓ኱㇋࢖ࢯࣇࣛ࣎ࣥ㢮ࡢஙࡀࢇ⣽⬊ቑṪᢚไ۵ᡞ㑔 㝯ኵ㸪ఫྜྷ ᬛᡂ㸪ᅵᒇ ⤮᲍ᯝ㸪᪂⸨ ᙬ஀㸪᪥ẚ ᬛᏊ㸪ᒸᮏ ㄃ኈ඾㸪᳜⏣ ᗣḟ㸪ᑠᔱ ௰ኵ㸦ྡᇛ኱࣭⸆㸧P-119Ꮫෆ඲㠃⚗↮࡟ྥࡅࡓ኱Ꮫ⏕ࡢႚ↮࡟㛵ࡍࡿព㆑ㄪᰝ 㸫♫఍ⓗࢽࢥࢳࣥ౫Ꮡࢆ
⤯ࡕษࡿႚ↮㜵Ṇᩍ⫱ࡢ㔜せᛶ㸫۵ᒣཱྀ ᏕᏊ㸪బ⸨ ⨾ె㸪᳃ᮏ ὈᏊ㸪ᒣ㷂 ⿱ᗣ㸦⚄ᡞᏛ㝔኱࣭⸆㸧

ศᯒἲ

P-120

࢝ࢸ࢟ࣥ⺯ගㄏᑟ໬ἲࡢ㛤Ⓨ࡜⥳Ⲕ㣧ᩱỈ࡬ࡢᛂ⏝ࠐᓊ ᬛ⿱㸪ᒾୗ ⳯㑣⨾㸪ᯇᔱ 㑥ᙪ㸪ฟཱྀ 㞝ஓ㸪㛗ᒸ ᜨ㸪㛗ᒸ ᐶ᫂㸦㛗ᓮᅜ㝿
኱࣭⸆㸧

ࡑࡢ௚

P-121

࢔ࢻࣜ࢔࣐࢖ࢩࣥ࡟ࡼࡿ HMG-CoA synthase ࡢάᛶపୗࢆ௓ࡋࡓ⣽⬊ẘᛶⓎ⌧ᶵᵓࡢゎᯒ‫ۑ‬ᮒ ಇ㌺㸪㧗ᶫ ຮ㸪㯤 ᇶ᪫㸪Ọ἟ ❶㸦ᮾ໭኱㝔࣭⸆㸧

P-122

p62:Nrf2 㑇ఏᏊ஧㔜Ḟᦆ࣐࢘ࢫ࡟࠾ࡅࡿ MRI ࢆ⏝࠸ࡓ NASH Ⓨ⑕࡜ࡑࡢ㐍ᒎᶵᗎࡢゎᯒ۵ụෆ ⨾✑㸪⛅ᒣ ೺ኴ㑻㸪ⷘ ᰤ἞㸪ṇ⏣ ⣧୍㸦⟃Ἴ኱࣭་Ꮫ་⒪⣔㸧P-123࣓ࢱࣟࢳ࢜ࢿ࢖ࣥ㑇ఏᏊḞᦆ࣐࢘ࢫࡢᑑ࿨࡟㛵ࡍࡿ◊✲۵㛛⏣ ెே㸪㫽ෆ ᭷㔛Ꮚ㸪Ỉ㔝 㞝Ⓩ㸪Ᏻ⸤ ཭㤶, 㧗ᓮ ᬛኈ, ᕝୖ 㝯ⱱ㸪బ⸨ ᨻ⏨㸪㕥ᮌ ┿ஓ㸦ᚨᓥᩥ⌮኱࣭⸆㸧

−41−

P-124᪂つ⾜ືゎᯒࢩࢫࢸ࣒ࢆ⏝࠸ࡓ㞟ᅋ㣫⫱ୗ࡟࠾ࡅࡿ࣐࢘ࢫࡢ♫఍ᛶ⾜ືゎᯒ۵Ᏹ἞⏣ ࿴ె 1㸪㐲⸨ ࡢࡒࡳ 1㸪㐲ᒣ ༓᫓ 1㸪᥃ᒣ ṇᚰ 1,2 㸦1 ᮾி኱㝔࣭་Ꮫ⣔◊✲⛉࣭೺ᗣ⎔ቃ་ᕤᏛ㒊㛛㸪2 㛗ᓮ኱㝔࣭་ṑ⸆Ꮫ⥲ྜ◊✲⛉࣭⚄⤒ᶵ⬟Ꮫศ㔝㸧P-125ࣄࢺ⬻࣑ࢡࣟࢯ࣮࣒࡟ࡼࡿ୺せ࢝ࣥࢼࣅࣀ࢖ࢻࡢ௦ㅰ
۵Ώ㎶ ࿴ே 1, ᐑᮏ ⨾బ 1㸪ᒾ⏣ ె♸ 1㸪Ᏹబぢ ๎⾜ 1㸪ᒣᢡ ኱ 2,㛗㇂ᕝ ᘯኴ㑻 3, Ώ㒊 ຍዉᏊ 3, 㕥ᮌ ಟ 3, ᒣᮏ 㑳⏨ 4㸦1 ໭㝣኱࣭⸆, 2 ಙᕞ኱࣭་,3὾ᯇ་኱㸪4 ඖ஑ಖ኱࣭⸆㸧P-126

ᾏὒ⏕≀⏤᮶ 2,2̓
-dimethoxy-BB80 ࡢࣛࢵࢺ࡟࠾ࡅࡿ in vivo ௦ㅰ۵すᮧᜨ⌮ ኴ⏣༓✑ 㸪ཎཱྀᾈ୍ 㸪㐲⸨ဴஓ 㸪ຍ⸨ၿஂ 㸪ᒣᮏ೺ኴ 㸪ྂ㈡ಙᖾ 㸦 ୰ᮧᏛᅬ኱࣭㝔࣭ᰤ㣴⛉Ꮫ㸪 ୰ᮧᏛᅬ኱࣭ᰤ㣴⛉Ꮫ ➨୍⸆⛉኱㸪໭་⒪኱࣭⸆㸪 ᚨᓥᩥ⌮኱࣭㤶ᕝ⸆㸧

P-127

N-࢔ࢭࢳࣝ-࣓ࢧࣛࢪࣥࡢ Caco-2 ⣽⬊༢ᒙ⭷㏱㐣࡟ཬࡰࡍࣀࣅࣞࢳࣥࡢᙳ㡪۵ᮡཎ ᡂ⨾㸪಴⏣ Ἃ⧊㸪ྜྷᒸ 㤶ኸ㔛㸪ୖᩜ㡿 ῟㸦⚟ᒣ኱࣭⸆㸧P-128ᚤᑠ⟶ᶵ⬟㜼ᐖ⸆ࡢ⾑⟶እ₃ฟ࡟ࡼࡿ⓶⭵യᐖ࣓࢝ࢽࢬ࣒ࡢ᳨ウ۵㧘▼㞞ᶞ㸯㸪ᑠᮡᒣ㏔Ꮚ㸯㸪బᕝ໶㸯㸪⊁㔝ṇᾈ㸯㸪ụ⏣ె⧊㸯㸪⳥ᆅ㝯┿㸯㸪Ṋ⏣฼᫂㸰㸪ὸ㔝ဴ㸯㸦㸯ᅜ㝿་⚟኱࣭⸆㸪㸰ᒾᡭ┴኱࣭┳ㆤ㸧

P-129

୰㛫࿘Ἴ☢⏺ࡢ⬇ẘᛶ۵すᮧ Ἠ㸪᰿ᓊ ṇ㸦㟁ຊ୰ኸ◊✲ᡤ࣭⎔ቃ⛉Ꮫ㸧

P-130

㢕⟶⭼ศἪᾮᡂศࡢಶே㛫࣭ಶேෆኚື࡟㛵ࡍࡿゎᯒ۵ᕝཱྀ┿ᮍ㸯㸪㧗ᮌ㑥᫂㸯㸰㸪▼಴㟹Ꮚ㸯㸪㛵ᮏᚁྐ㸯㸪᰿ᮏΎග㸯㸪ฟᕝ㞞㑥㸯㸪ྜྷᡂᾈ୍㸯㸦㸯㟼ᒸ┴❧኱࣭⸆㸪㸰㯞ᕸ኱࣭⏕࿨࣭⎔ቃ㸧

P-131

ᐙᗞ⏝ࢫࣉ࣮ࣞ〇ရࡢ౑⏝࡟క࠺೺ᗣ⿕ᐖ஦౛ࡢゎᯒ۵Ἑୖ ᙉᚿ㸪ఀబ㛫 ࿴㑻㸪஬༑ᔒ Ⰻ᫂㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ࣭⏕ά⾨⏕
໬Ꮫ㒊㸧

P-132

࣏ࣜሷ໬ࣅࢽࣝ〇ရῧຍ๣ࡢ⓶⭵ឤసᛶホ౯۵஬༑ᔒ Ⰻ᫂㸪ᑠ℈ ࡜ࡶᏊ㸪Ἑୖ ᙉᚿ㸪ఀబ㛫 ࿴㑻㸦ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲
ᡤ࣭⏕ά⾨⏕໬Ꮫ㒊㸧

P-133ᅜ㝿Ᏹᐂࢫࢸ࣮ࢩࣙࣥࠕࡁࡰ࠺ࠖ࡟࠾ࡅࡿ⣽⳦ࣔࢽࢱࣜࣥࢢ
۵୍ᲄ▱᫛㸯㸪ᒣཱྀ㐍ᗣ㸯㸪㤿ሙ㈗ᚿ㸯㸪㑣㡲ṇኵ㸯㸦㸯኱㜰኱㝔࣭⸆㸪㸰㫽ྲྀ኱࣭㎰㸧

−42−

㡑ᅜ₇㢟

P-134

Prothrombotic risk associated with intravenously given high dose vitamin C:
Another evidence warning against the blind faith in vitamins?
‫ۑ‬Keunyoung Kim1, Ok-Nam Bae2, Sung-Hee Koh1, Bian Yiying1, andJin-Ho Chung1 (1Coll. Pharm., Seoul National Univ., 2Coll. Pharm., Hanyang
Univ., Korea)

P-135

Procoagulant and prothrombotic effects of the herbal medicine, Dipsacus asperand its active ingredient, dipsacus saponin C, on human platelets‫ۑ‬Ji-Sun Song, Keunyoung Kim, Yeryeon Jung, and Jin-Ho Chung (Coll.
Pharm., Seoul National Univ., Korea)

P-136

Alteration of oral toxicokinetic profiles of melamine by combined treatment ofrats with cyanuric acid‫ۑ‬Tae Cheon Jeong, Mi Jeong Kang, Keunhan Noh, Wonku Kang1,
Hyung Sik Kim2ム1College of Pharmacy, Yeungnam University, Korea, 2Collegeof Pharmacy, Chung-Ang University, Korea, College of Pharmacy,
Sungkyunkwan University, Korea㸧

P-137

Metformin increases microrna-34a to down-regulate sirt1 expression leading toenhanced sensitivity of wild-type p53 cancer cells to oxidative stress‫ۑ‬Minh Truong Do, Hyung Gyun Kim, Hye Gwang Jeong 㸦Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸧

P-138

Metallothion-iii increases adam10 activity on non-amyloidogenic processing inneuronal cells‫ۑ‬Bong Hwan Park, Hyung Gyun Kim, Hye Gwang Jeong㸦Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸧

P-139

Inhibitory effcts of saponins from the roots of platycodon grandiflorum on
ovalbumin-induced mice‫ۑ‬Jae Ho Choi1, Hyung Gyun Kim1, Young Chul Chung2, Hye Gwang Jeong1
㸦 1Department of Toxicology, College of Pharmacy, Chungnam National
University, Korea㸪2Department of Food and Medicine, College of Public Healthand Natural Science, International University of Korea, Korea㸧

−43−

P-140

Saponins from the roots of platycodon grandiflorum attenuates high fat
diet-induced non-alcoholic steatohepatitis in rats by inducing nrf2-mediatedantioxidant enzymes‫ۑ‬Se Jong Kim1, Young Chul Chung2, Hye Gwang Jeong1㸦1Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸪
2Department of Food and Medicine, College of Public Health and Natural
Science, International University of Korea, Korea㸧

P-141

Effect of betulinic acid on nitric oxide synthase phosphorylation and nitric oxide
production in endothelial cells‫ۑ‬Sun Woo Jin, Hye Gwang Jeong㸦Department of Toxicology, College of
Pharmacy, Chungnam National University, Korea㸧

P-142

Saponins from the roots of platycodon grandiflorum, especially platycodin d,
attenuates atopic dermatitis-like skin symptoms dncb-induced mice and tnf-Ș
/ifn-Ț-exposed cells‫ۑ‬Jae Ho Choi1, Young Chul Chung2, Hyun-Sun Lee3, Hye Gwang Jeong1
㸦 1Department of Toxicology, College of Pharmacy, Chungnam National
University, Korea㸪2Department of Food and Medicine, College of Public Healthand Natural Science, International University of Korea, Korea㸪3Molecular
Cancer Research Center, Korea Research Institute of Bioscience andBiotechnology, Korea㸧

P-143

Anticancer effect of Hyrtios sp. extract in human colon carcinoma cells withdifferent p53 status‫ۑ‬Joohee Jung1, Woori Bae1, Hyun Kyung Lim1, Ki Hwa Jung1, Youngmi Kim1,
Hyi-Seung Lee2㸦1College of Pharmacy, Duksung Women’s University, Korea㸪
2Korea Institute of Ocean Science & Technology, Korea㸧

P-144

Aroma therapy with essential oils in menopausal women or dementia patientschanges plama levels of cortisol and 5-ht
‫ۑ‬Young-Sook Kang 㸦Research Center for Cell Fate Control, College of
Pharmacy, Sookmyung Women’s University, Korea㸧

P-145

Acacetin sensitize HepG2 cells to TRAIL through DR5 up-regulation‫ۑ‬Su Jung Han and An Keun Kim㸦College of Pharmacy, Sookmyung Women’s
University, Korea㸧

P-146

Selenium-binding protein 1 is a sensitive urinary biomarker for detection ofnephrotoxicity‫ۑ‬Kyeong Seok Kim, Ji Yeon Son, and Hyung Sik Kim㸦Division of Toxicology,
School of Pharmacy, Sungkyunkwan University, Korea㸧

−44−

P-147

Metabolomics profiling against cadmium-induced nephrotoxicity in the urine ofSprague-Dawley rats
‫ۑ‬Yoon Jong Kang, Ji Yeon Son, and Hyung Sik Kim㸦Division of Toxicology,
School of Pharmacy, Sungkyunkwan University, Korea㸧

P-148

Uric acid induces endothelial dysfunction by vascular insulin resistanceassociated with the impairment of nitric oxide synthesis‫ ۑ‬You-Jin Choi, Byung-Hoon Lee (College of Pharmacy, Seoul National
University, Korea)

P-149

Maternal exposure to simazine impairs the development of female mouseoffspring‫ۑ‬Seeun Park1, Sarang Kim1, Hong Jin1, Daeyoung Kim2, Kangseok Lee2 andJeehyeon Bae1㸦1School of Pharmacy, 2Department of Life Science, Chung-Ang
University, Korea㸧

P-150

A study for safety management of bisphenol A‫ۑ‬Mihi Yang and Myoung-Yun Pyo㸦Research Center for Cell Fate Control,
College of Pharmacy, Sookmyung Women’s University, Korea㸧

P-151

A molecular epidemiological study to clarify tobacco smoking-specific toxic
mechanisms‫ۑ‬Mihi Yang㸦Research Center for Cell Fate Control, College of Pharmacy,
Sookmyung Women’s University, Korea㸧

P-152

Polyhexamethylene guanidine phosphate induced inflammatory responses via
ROS-Nf-ǋB signaling pathway
۵Ha Ryong Kim, Da Young Shin, Min Sun Yi, Wun Hak Choo, Jeong Eun Lee,
Han Soo Cho, Kyu Hyuck Chung㸦School of Pharmacy, Sungkyunkwan
University, Korea㸧

−45−環境・衛生部会委員会拡大会議
9 月 19 日（金） 12：10 ～ 13：00
会場：B 会場（つくば国際会議場大会議室 102）

懇親会
9 月 19 日（金） 18：30 ～ 20：30
会場：懇親会会場（オークラフロンティアつくばホテル本館）
環境・衛生部会学術賞

授賞式

環境・衛生部会賞・金原賞

授賞式

優秀若手研究者賞

受賞者発表・授賞式

実行委員長賞

受賞者発表・授賞式

環境・衛生部会新人賞

受賞者発表・授賞式−46−

Educational Lecture
September 20 (Sat) 11:00-11:50 Room A
Chair: Akira Naganuma (Tohoku Univ. Grad. School of Med.)

EL-1

Food safety and risk assessment of environmental pollutants
Hiroshi Satoh (Food Safety Commission, Cabinet Office)

Plenary Lectures
September 19 (Fri) 11:10-12:00 Room A
Chair: Toshiyuki Kaji (Fac. Pharm. Sci., Tokyo Univ. of Sci.)

PL-1

The earth, the space, and human well-being
Tadashi Murai (Space Biomedical Research Office, Japan Aerospace
Exploration Agency)

September 19 (Fri) 17:00-18:00 Room A
Chair: Yoshito Kumagai (Fac. of Med., Univ. of Tsukuba)

PL-2

Solving the mystery of Sleep ~Forward Genetics in Mice~
Masashi Yanagisawa (International Institute for Integrative Sleep Medicine(WPI-IIIS), University of Tsukuba)

Award Lectures
Scientific Award
September 20 (Sat) 12:50-13:20 Room A
Chair: Akira Naganuma (Tohoku Univ. Grad. School of Med.)

AL1

Molecular basis of toxicity of, and inter-individual susceptibility to indoor
chemicals
Hideto Jinno (National Institute of Health Sciences)−47−

Kanehara Award
September 20 (Sat) 13:20-13:40 Room A
Chair: Toshiyuki Kaji (Fac. Pharm. Sci., Tokyo Univ. of Sci.)

AL2-1

Studies on proteins involved in the sensitivity to toxic compounds
Tsutomu Takahashi (Grad. Sch. of Pharm. Sci., Tohoku Univ.)

September 20 (Sat) 13:40-14:00 Room A
Chair: Shigeki Shinba (Sch. Pharmacy, Nihon Univ.)

AL2-2

Studies on the molecular mechanism of TCDD toxicity through the analysis of
AhR function
Taira Wada (Dep. Health Sci. Sch. Pharmacy, Nihon Univ.)

Invited Lecture
September 19 (Fri) 10:30-11:00 Room A
Chair: Seiichiro Himeno (Fac. Pharm. Sci., Tokushima Bunri Univ.)

IL-1

High performance metabolic profiling to identify urine biomarkers incorticosteroid insensitive asthmatic children
۵Youngja Park1, 2, Anne M Fitzpatrick3, Steven Kim1, Yongliang Liang1, andDean P Jones1(1Department of Medicine, Emory University, 2College of Pharmacy, Korea
University, 3Department of Pediatrics, Emory University)−48−

2014 Japan/Korea Joint Symposium on Pharmaceutical Health
Science and Environmental Toxicology
September 19 (Fri) 14:00-15:00 Room A
Chair: Mi-Hi Yang (Sookmyung Women's University)
Gi-Wook Hwang (Tohoku University)

S-1

Regulation of p53 by cadmium in proximal tubular cells
۵Jin-Yong Lee1, Maki Tokumoto1, Yasuyuki Fujiwara2, Masahiko Satoh1
㸦1Sch. of Pharm., Aichi Gakuin Univ., 2Sch. of Pharm., Tokyo Univ. of Pharm.
and Life Sci.㸧

S-2

The hepatoprotective effect of sestrin2: the link between redox regulation andinflammation
۵Sung Hwan Ki (College of Pharmacy, Chosun University, Korea)

S-3

Multi-step Regulation of Nrf2 Activity in the Liver
۵Keiko Taguchi1,2, Hozumi Motohashi1, Masayuki Yamamoto2 (1Gene Exp
Reg, IDAC, 2Med Biochem, Grad Sch Med, Tohoku Univ)

S-4

Enhanced GSK3ǃ-mediated serine 33 phosphorylation of FOXL2 confers
oncogenicity to ovarian granulosa cell tumors bearing the highly conserved
C134W mutation۵Jeehyeon Bae (School of Pharmacy, Chung-Ang University, Korea)−49−

Forum I: New strategies for elucidation of the mechanism
underlying metal toxicity
September 19 (Fri) 8:50-10:30 Room A
Chair: Yasumitsu Ogra (Showa Pharm. Univ.)
Yasuyuki Fujiwara (Tokyo University of Pharmacy and Life Science)

F1-1

Organotin-induced neuronal effects via GluR2 decrease۵Yaichiro Kotake (Inst. of. Biomed. and Health. Sci., Hiroshima Univ.)

F1-2

Metal-mediated epigenetic regulations of gene expression
۵Tomoki Kimura (Fac. Pharm. Sci., Setsunan Univ.)

F1-3

Cadmium transport in epithelial cells of kidney proximal tubule and intestine۵Hitomi Fujishiro, Seiichiro Himeno (Fac. Pharm. Sci., Tokushima Bunri
Univ.)

F1-4

The relationship between methylmercuty toxicity and autophagy suppressor
EGO complex
۵Gi-Wook HWANG (Grad. Sch. of Pharm. Sci., Tohoku Univ.)−50−

Forum II: Rediscovery of reactive sulfur species and novel
development of redox biology
September 19 (Fri) 15:00-17:00 Room A
Chair: Takaaki Akaike (Tohoku Univ. Grad. Sch. Med.)
Motohiro Nishida (Okazaki Inst. Integr. Biosci.)

F2-1

Reactive sulfur species mediates oxidative stress response involving polysulfur
biology۵Takaaki Akaike (Dept. of Environ. Health Sci. Mol. Toxicol., Tohoku Univ.
Grad. Sch. Med.)

F2-2

Novel mechanism of methylmercury-induced neurotoxicity: Disruption ofreactive sulfur species-regulated NO/ROS redox signaling۵Hdeshi Ihara (Graduate School of Science, Osaka Prefecture University)

F2-3

Regulation of cardiac remodeling by reactive sulfur species
۵Motohiro Nishida1,2,3, Takashi Toyama1,4,6, Takaaki Akaike5,
Yoshito Kumagai6 (1Okazaki Inst. Integr. Biosci. (Nat. Inst. Physiol. Sci.), 2Grad.
Sch. Pharm. Sci. Kyushu Univ., 3JST, PRESTO, 4Grad. Sch. Pharm. Sci., Tokyo
Univ. Sci., 5Tohoku Univ. Grad. Sch. Med., 6Fac. of Med., Univ. of Tsukuba.)

F2-4

Redox regulation of biological enzymes by reactive cysteine peresulfides
synthesized from cystine۵Yasuo Watanabe (Pharmacology Showa Pharmaceutical Univ.)−51−

Forum III: Risk assessment of nanomaterials
September 20 (Sat) 8:50-10:50 Room A
Chair: Jun Kanno (National Institute of Health Sciences)
Gaku Ichihara (Fac. Pharmaceut. Sci., Tokyo Univ. Sci. Univ.)

F3-1

Animal models in risk assessment for manufactured nanomaterials
۵Gaku Ichihara1, Wenting Wu2, Radwa Sehsah2, Esteban C. Gabazza3,
Ken Ito4, Masayuki Yamamoto5, Sahoko Ichihara6 (1Fac. Pharmaceut. Sci.,
Tokyo Univ. Sci. Univ., 2Grad. Sch. Med., Nagoya Univ., 3Grad. Sch. Med., Mie
Univ., 4Sch. Med. Hirosaki Univ., 5Grad. Sch. Med. Tohoku Univ., 6Grad. Sch.
Regional Innovation Studies, Mie Univ.)

F3-2

Cellular uptake and toxicity mechanism of nanofibers
۵Seishiro Hirano (RCER, Natl. Inst. Environ. Studies)

F3-3

Health Effects of Nanomaterials on the Next Generation
۵ Ken Takeda1 Ken Tachibana1,2 and Masakazu Umezawa1 (1ResearchInstitute for Science and Technology, Tokyo University of Science, 2Nihon
Pharmaceutical University)

F3-4

Hazard Assessment of Nanomaterials Especially of Its Chronic Aspects
۵Jun Kanno1, Yuhji Taquahashi1, Koichi Morita1, Masaki Tsuji1,
Atsuya Takagi1, Yukio Ogawa1, Akihiko Hirose2 (1Div. Cell. Mol. Tox. and 2Div.
Risk Assess., BSRC, National Institute of Health Sciences)−52−

Forum IV: Daily environmental toxicology –new approaches forthe study of health effects–
September 20 (Sat) 14:00-16:00 Room A
Chair: Hideto Jinno (Natl. Inst. Health Sci.)
Eiko Koike (Natl. Inst. Environ. Studies)

F4-1

Effects of environmental chemicals on inflammatory response
۵Eiko Koike (Ctr. Environ. Health Sci., Natl. Inst. Environ. Studies)

F4-2

Noxious stimulation by chemicals in indoor environment
۵Toshiko Tanaka-Kagawa1, Susumu Ohkarawa2, Hideto Jinno1 (1Natl. Inst.
Health Sci., 2Sch. Pharmaceut. Sci., Kyushu Univ. Health and Welfare)

F4-3

Effects of prenatal maternal exposure to plasticizer on offspring۵Tamie Nasu (College of Life and Health Sciences, Chubu University)

F4-4

Health effects of electromagnetic field exposure on mice and rats
۵Naoki Kunugita1, Tin-Tin Win-Shwe2, Shin Ohtani1, and Akira Ushiyama1(1Dept. Environ. Health, Natl. Inst. Public Health, Wako, Saitama, Japan, 2 Natl.
Inst. Environ. Studies, Tsukuba, Ibaraki, Japan,)−53−

Award Candidates Presentation
Candidates for Young Investigator Award
September 19 (Fri) 9:00-10:05 Room B
Chair: Yoshito Kumagai (Fac. of Med., Univ. of Tsukuba)

P-19

Reduced lysosomal function and impaired autophagy induced by low
concentration of Parkinson’s disease-related chemical۵Masatsugu Miyara1, 3, Yaichiro Kotake1, 2, Wataru Tokunaga2, Shigeru Ohta1, 2(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. of Pharmaceut.
Sci., Hiroshima Univ., 3JSPS Research Fellow)

P-21

A novel mechanism for growth retardation produced by maternal exposure todioxin: a study focusing on growth hormone in perinatal pups
۵Yukiko Hattori, Tomoki Takeda, Misaki Fujii, Waka Izumoto, Yuji Ishii,
Hideyuki Yamada (Grad. Sch. Pharmaceut. Sci., Kyushu Univ.)

P-60

Potential protection of major urinary protein 1 against organotins-induced
toxicity in mice۵Akira Aoki, Yuki Otsuka, Tsuyoshi Nakanishi, Nagase Hisamitsu (Gifu
Pharm. Univ.)

P-68

Clarification of mechanism underlying metallothionein induction in vascularendothelial cells using a copper complex
۵Tomoya Fujie1, Hiroshi Naka2, 3, Yasuyuki Fujiwara3, 4, Toshiyuki Kaji1, 3 (1Fac.
Pharm. Sci., Tokyo Univ. of Sci., 2Res. Center Mater. Sci., Nagoya Univ., 3RIST,
BOM, Tokyo Univ. of Sci., 4Sch. Pharm., Tokyo Univ. Pharm. & Life Sci.)

P-74

Cellular GAPDH restricts efficient priming of HIV reverse transcription
۵Naoki Kishimoto1, Ayano Onitsuka1, Nobutoki Takamune2, Shogo Misumi3(1Grad. Sch. Pharmaceut. Sci., Kumamoto Univ., 2KICO, Kumamoto Univ.,
3Grad. Sch. Life Sci., Kumamoto Univ.)

P-75

Effect of cytoplasmic distribution of Hepatitis C virus core protein on inductionof unfolded protein response and lipid droplet formation: analysis using
budding yeast model system
۵Shingo Iwasa, Kenta Iwai, Shusuke Kuge (Dept. of Microbiology, Tohoku
Pharmaceutical University)

P-88

Regulatory mechanism of detoxification and excretion of bile acids by themolecular clock system
۵Kenshin Yoshida, Taira Wada, Shigeki Shimba  (Sch. Pharmacy, Nihon
Univ.)−54−

P-101PXR activation accelerates the growth factor-dependent hepatocyte
proliferation
۵Taiki Abe1,2, Ryota Shizu1, Atsushi Matsuzawa1, Kouichi Yoshinari1,2 (1Grad.
Sch. Pharmaceut. Sci., Tohoku Univ., 2Sch. Pharmaceut. Sci. Univ. Shizuoka)

P-105

Biglycan suppresses syndecan-4 expression mediated by ALK5 signaling
cooperatively with TGF-ǃ1
۵Takato Hara, Toshiyuki Kaji (Fac. of Pharm. Sci., Tokyo Univ. of Sci.)−55−

Award Candidates Presentation
Candidates for Rookie of the Year Award
September 19 (Fri) 10:05-11:10 Room B
Chair: Yaichiro Kotake (Fac. Pharm. Sci., Hiroshima Univ)

P-22

Mechanism by which dioxin reduces the maternal expression of prolactin
during the nursing periods and its effect on pup maturation.
۵Waka Izumoto, Tomoki Takeda, Misaki Fujii, Yukiko Hattori, Yuji Ishii,
Hideyuki Yamada (Fac. Pharmaceut. Sci., Kyushu Univ.)

P-23

Mechanism whereby maternal exposure to dioxin fixes the status of the lowered
expression of gonadotropin-releasing hormone in the offspring: an analysis
focusing on the metabolome.
۵ Kyoko Nishida, Tomoki Takeda, Yuji Ishii, Hideyuki Yamada (Fac.
Pharmaceut. Sci., Kyushu Univ.)

P-25

Mice lacking Ah receptor in the adipose tissue are resistant to high fat
diet-induced adipose tissue inflammation and diabetes.
۵ Yuki Kasakura, Taira Wada, Shigeki Shimba (Dep. Health Sci. Sch.
Pharmacy, Nihon Univ.)



P-32

Combination effects of benzimidazoles on the chemical ligand
mediated-activation of AhR in human hepatoma cell lines.
۵Seiko Nagasawa1, Masashi Sekimoto1, Aika Tasaki1, Akiyoshi Nishikawa2,
Takashi Uemura2, Kiyomitsu Nemoto1, Kouichi Yoshinari1, Msakuni Degawa1(1Dept. Mol. Toxicol., Sch. Pharm. Sci., Univ, Shizuoka., 2Natl. Inst. Health Sci.)

P-45

Methylmercury toxicity in the fibrinolytic system of cultured human brain
microvascular endothelial cells
۵Miho Tanaka1, Masaru Kurita1, Eiko Yoshida1, Chika Yamamoto2, Toshiyuki Kaji1(1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Toho Univ.)

P-51

Effect of long-term exposure to cadmium on metallothionein expression inmouse lymphosarcoma P1798 cells
۵Fuyuri Fukumoto, Ryo Kimura, Takuomi Hosaka, Tomoki Kimura (Fac.
Pharm. Sci., Setsunan Univ.)

P-59

Ovarian functions modify triphenyltin-induced toxicity in adult female mice۵Yuki Otsuka, Akira Aoki, Tsuyoshi Nakanishi, Hisamitsu Nagase (Gifu
Pharm. Univ.)

P-84

Macrophage-recognition of modified-LDL through macrophage surface receptor
nucleolin
۵Yoshihiro Tachibana1, Yukari Ohminato1, Yuichi Miki1, Kazuya Hirano2,
Masatoshi Beppu1, Yasuyuki Fujiwara1 (1Tokyo University of Pharmacy and Life
Science, 2Takasaki University of Health and Welfare)

−56−

P-87

BKA, an apoptosis inhibitor: a novel utility of BKA as a PPARȖ-selective
activator
۵Aya Taniguchi1, Eriko Ikeda1, Shuso Takeda2, Miki Tokuyasu1,
Hiroyuki Ishii1, Yasushi Yoshioka1, Hajime Nishimura1, Hiroyuki Okazaki1,
Kenji Matsumoto3, Shindo Mitsuru3, Hironori Aramaki1 (1Daiichi Univ. Pharm.,
2Fac. Pharm. Sci., Hiroshima Int’l Univ., 3IMCE, Kyushu Univ.)−57−

Oral Sessions
Environmental pollutants1
September 19 (Fri) 15:10-16:00 Room B
Chair: Seishiro Hirano (National Institute for Environmental Studies)
Masashi Sekimoto (Sch. Pharm. Sci., Univ, Shizuoka)

O1-1

Difference in the effects of prenatal exposure to carbon black nanoparticle on
lymphoid tissues during neonatal period by exposure period۵Atsuto Onoda1,2, Saki Okamoto1, Ryuhei Shimizu1, Syuhei Ogawa3,
Shiho Watanabe3, Ryo Abe3, Ken Takeda2, Masakazu Umezawa2 (1Grad. School
Pharm. Sci., 2Cent. Env. Health Next Gen., RIST, and 3Div. Immunobiol., Res.
Inst. Biol. Sci., Tokyo Univ. Sci.)

O1-2

Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory
response to bleomycin-induced pulmonary fibrosis in mice
۵Wenting Wu1, Gaku Ichihara2, Naozumi Hashimoto3, Yoshinori Hasegawa3,
Yasuhiko Hayashi4, Masashi Kato1, Saeko Tada-Oikawa5, Yuka Suzuki5,
Jie Chang1, Corina N. D'Alessandro-Gabazza6, Esteban C. Gabazza6,
Sahoko Ichihara5 (1Department of Occupational and Environmental Health,
Nagoya University Graduate School of Medicine, 2Department of Occupational
and Environmental Health, Tokyo University of Science, Japan㸪3Departmentof Respiratory Medicine, Nagoya University Graduate School of Medicine,
4Department of Electrical and Electronic Engineering, Okayama University,
5Graduate School of Regional Innovation Studies, Mie University, 6Department
of Immunology, Mie University School of Medicine)

O1-3

Involvement of Nrf-2 in zinc oxide nanoparticles-induced pulmonary
inflammation
۵Radwa Sehsah1, 6, Wenting Wu1, Sahoko Ichihara2, Naozumi Hashimoto3,
Yoshinori Hasegawa3, Ken Ito4, Masayuki Yamamoto5, Emily Kamel6,
Gaku Ichihara7 (1Department of Occupational and Environmental Health,
Nagoya University Graduate School of Medicine, 2Mie University Graduate
School of Regional Innovation Studies, 3Department of Respiratory Medicine,
Nagoya University Graduate School of Medicine, 4Department of StressResponse Medicine, Hirosaki University Graduate School of Medicine,
5Department of Medical Biochemistry, Tohoku University Gradute School of
Medicine, 6Department of Public Health and Community Medicine, Mansoura
Faculty of Medicine, Egypt, 7Department of Occupational and Environmental
Health, Tokyo University of Science. )O1-4

Impaired Lipid and Glucose Homeostasis in
Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet
۵Rie Yanagisawa1, Eiko Koike1, Tin-Tin Win-Shwe1, Hirohisa Takano2(1 National Inst Environm Studies, 2Grad. Sch. Engineering, Kyoto Univ.)−58−

Environmental pollutants2࣭Brain࣭Neural toxity࣭Biochemistry
September 19 (Fri) 16:00-16:50 Room B
Chair: Daigo Sumi (Fac. Pharmaceut. Sci., Tokushima Bunri Univ.)
Koji Ueda (Fac. of Pharm, Meijo Univ)

O2-1

Fetal benzo[a]pyrene exposure impairs male reproductive function in mice
۵Takayuki Kumamoto, Yasutaka Komine, Naoki Takayanagi, Shigeru Oshio(Fac. Pharmaceut. Sci., Ohu Univ.)

O2-2

Detection of epigenetic effects induced by environmental chemicals in mouse
ES cells harboring GFP-MBD-lns
۵Wenlong WANG1㸪Qin ZENG1㸪Hiroko NANSAI1, Kuniya ABE2,
Hideko SONE1 (1National Institute for Environmental Studies, 2Riken
BioResource center)O2-3

Developmental neurotoxicity in young adult mice following exposure tointermediate-frequency magnetic field۵Tin-Tin Win-Shwe,1 Shin Ohtani,2 Akira Ushiyama,2 and Naoki Kunugita2(1National Institute for Environmental Studies, Tsukuba, 2 National Institute of
Public Health, Wako City)

O2-4

Major urinary protein 1 inhibits lipid accumulation to regulate glucose andlipid metabolism in male mice.
۵Kouhei Fujitani, Akira Aoki, Tsuyoshi Nakanishi, Nagase Hisamitsu (Gifu
Pharm. Univ.)−59−

Endocrine disruptors
September 20 (Sat) 9:00-10:00 Room B
Chair: Hideyuki Yamada (Grad Sch Pharmaceut Sci, Kyushu Univ.)
Shuso Takeda (Fac. Pharm. Sci., Hiroshima Int’l Univ.)

O3-1

Effects of metabolism of pyrethroid and carbamate pesticides by rat liver
microsome on their PXR, CAR and PPARĮ activation.
۵Chieri Fujino1, Yoko Watanabe1, Naoto Uramaru1, Hiroyuki Kojima2,
Kouichi Yoshinari3,4, Shigeyuki Kitamura1 (1Nihon Pharmaceut. Univ.,
2Hokkaido Inst. Public Health, 3Sch. Pharmaceut. Sci., Univ. Shizuoka., 4Grad.
Sch. Pharmaceut. Sci., Tohoku Univ.)

O3-2

Effects of pesticides and endocrine disrupters on cell viabilities and cytochrome
P450 inductions in Human HepaRG Cells
۵Hideko Sone1, Norie Murayama2, Wenglong Wong1, Hiroko Nansai1,
Qin Zeng1, Hiroshi Yamazaki2 (1Center Environmental Risk Research, Nat.
Env. Studies, 2 Showa Pharm. Univ.)O3-3

AhR prevents lipotoxicity in the liver
۵Taira Wada, Kazuki Miyata, Hiroshi Sunaga, Haruno Shirasaki,
Yuki Uchiyama, Shigeki Shimba (Dep.Health Sci. Sch. Pharmacy, Nihon
Univ.)

O3-4

Dioxin-produced facilitation of leukotriene B4 biosynthesis: its mechanism andrelevance to disorders including inflammation
۵Yukiko Komiya1, Tomoki Takeda1, Akihiko Koba1, Yuji Ishii1, Michio Nakaya1,
Hitoshi Kurose1, Takehiko Yokomizo2, Takao Shimizu3, Hiroshi Uchi4,
Masutaka Furue4, Hideyuki Yamada1 (1Grad. Sch. Pharmaceut. Sci., Kyushu
Univ., 2Grad. Sch. Med., Juntendo Univ., 3Natl. Ctr. Glob. Health & Med.,
4Kyushu Univ. Hospital)

O3-5

Effect of Perinatal TCDD Exposure on Cortico-Limbic HPA Axis in Mice
۵Seico Benner1, Yunjie Ding1, Taiki Inoshita1, Masaki Kakeyama2,
Chiharu Tohyama1 (1 Grad. School of Med., the University of Tokyo, 2Grad. Sch.
Biomed., Nagasaki Univ.)−60−

Oxidative stress࣭Cellular responses
September 20 (Sat) 10:00-11:00 Room B
Chair: Shuntaro Hara (Sch. of Pharmacy, Showa Univ.)
Yasumi Anan (Showa Pharm. Univ.)

O4-1

Photodynamic therapy in combination with talaporfin sodium induced cell
death modalities in glioma cells
۵Yuichi Miki1, Jiro Akimoto2, Chihiro Hironaka1, Masatoshi Beppu1,
Yasuyuki Fujiwara1 (1Tokyo University of Pharmacy and Life Sciences., 2Tokyo
Medical University.)

O4-2

Analysis of novel cell death pathway triggered by lipid peroxidation
۵Masaki Matsuoka1, Sinsaku Harada1, Hiroyuki Arai2, Hirotaka Imai1(1 Kitasato Univ. School of Pharmacy, 2Graduate school of Pharmaceutical
Science, Faculty of Pharmaceutical Sciences, The university of tokyo)

O4-3Role of innate immune signaling in oxidative stress-induced NF-kappaB
activation
۵Makio Hayakawa, Satoshi Furukori, Saki Jiromaru, Tomomi Matsui, andNatsumi Ida (Sch. Pharm., Tokyo Univ. Pharm. & Life Sci.)

O4-4

Hydrogen peroxide induces alternative splicing of arsenic methyltransferase
۵Daigo Sumi, Chieri Takeda, Seiichiro Himeno (Fac. Pharmaceut. Sci.,
Tokushima Bunri Univ.)

O4-5

Regulation of Interleukin 2 expression by an ER stress-induced protein TRB3
۵Takumi Nohara , Kazuya Sugiyama , Chiharu Miyajima , Yuka Itoh ,Yasumichi Inoue , Hidetoshi Hayashi (Grad. Sch. Pharmaceut. Sci., Nagoya
City Univ.)−61−

Metals
September 20 (Sat) 14:10-15:10 Room B
Chair: Chika Yamamoto (Fac. of Pharm. Sci., Toho Univ.)
Kayoko Kita (Fac. Pharm. Sci., Teikyo Univ.)

O5-1

The mechanisim of arsenite-induced suppression of lymphocytes proliferation
via p16-cdk4 complex increase۵Kazuyuki Okamura, Keiko Nohara (Center for Environmental Health
Sciences, National Institute for Environmental Studies)

O5-2

Significance of nail mercury concentrations as a biomarker of methylmercury
exposure in relation to segmental hair mercury concentrations at earlygestation and parturition
۵Mineshi Sakamoto1, Katsuyuki Murata2 (1Department of Environmental
Science and Epidemiology, National Institute for Minamata Disease,
2Department of Environmental Health Sciences, Akita University School of
Medicine)

O5-3

Evaluation of brain oxidation and neuronal dysfunction induced bymethylmercury using magnetic resonance imaging
۵Yasuhiro Ishihara1, Kohichi Itoh2, Ryohei Takahashi1, Atsuhiko Ishida1,
Takeshi Yamazaki1 (1Grad. Sch. Integ. Arts Sci., Hiroshima Univ., 2 Facul.
Pharmaceut. Sci. Kagawa, Tokushima Bunri Univ.)

O5-4

Astrocytic adaptive response induced by methylmercury and its
neuroprotective action.
۵Takuya Takemoto, Yasuhiro Ishihara, Atsuhiko Ishida, Takeshi Yamazaki(Grad. Sch. Integ. Arts Sci., Hiroshima Univ.)

O5-5

Molecular mechanism underlying increase in cardiac risk by Mechylmercury
۵Takashi Toyama1,2,3, Yoshito Kumagai4, Toshiyuki Kaji2, Takaaki Akaike5,
Motohiro Nishida1,6,7 (1Okazaki Inst. Integr. Biosci. (Nat. Inst. Physiol. Sci.),
2 Grad. Sch. Pharm. Sci., Tokyo Univ. Sci., 3JSPS fellow, 4Fac. of Med., Univ. of
Tsukuba. 5Tohoku Univ. Grad. Sch. Med., 6Grad. Pharm. Sci. Kyushu Univ.,
7JST, PRESTO, Sch.)−62−

Immunotoxicity࣭Infectious diseases࣭Others
September 20 (Sat) 15:10-16:00 Room B
Chair: Hisamitsu Nagase (Gifu Pharm. Univ.)
Tomoki Takeda (Grad. Sch. Pharmaceut. Sci., Kyushu Univ.)

O6-1

Difference in the Sensitivity to Oxidative Stress between Mycobacterium bovis
BCG Tokyo 172 -1 and -2.
۵Atsuro Takami1, Haruka Tomita1, Jun-ichi Maeyama2, Saburo Yamamoto3
and Takemasa Takii1 (1Dep. Hygienic Chem. , Grad. Sch. Pharmaceut. Sci.,
Nagoya City Univ., 2 Dep. Safety Res. on Blood and Biological Products, Nati.
Ins. Infec. Dis., 3Japan BCG Lab.)

O6-2

Combination of shikonin and lipopolysaccharide induces rapid cell death ofmacrophage like cell line, J774.1/JA-4 cells
۵Atsushi Koike, Makio Shibano, Hideya Mori, Kiyoko Kohama, Ko Fujimori
and Fumio Amano (Osaka Univ Pharm Sci.)

O6-3

Effects of Lipopolysaccharide (LPS) of asian sand dust on male reproductivefunction
۵Seiichi Yoshida, Takamichi Ichinose (Oita Univ. Nurs. Health Sci.)

O6-4

Development of microfluidic system for on-site microbial monitoring in space
habitats
۵Nobuyasu Yamaguchi, Yudai Fujii, Masao Nasu (Grad. Sch. Pharmaceut. Sci.,
Osaka Univ.)−63−

Poster Sessions Room 201, 202
Discussion:
Odd㸸September 19 (Fri) 13:00-14:00㸪Even㸸September 20 (Sat) 16:00-17:00
Environmental pollutants

P-1

Observational study on transborder air pollution during the winter and springmonths at 3 prefectures on the Japan Sea
۵Souleymane Coulibaly1, Masahiro Yamada1, Ryo Ono1, Hiroki Minami1,
Maho Abe1, Akane Kishi1, Motoki Matsui1, Tomohiro Hasei1, Nobuyuki Sera2,
Tadashi Oro3, Mizuka Kido4, Kunihiro Funasaka5, Daichi Asakawa5,
Masanari Watanabe6, Keiji Wakabayashi1,7, Tetsushi Watanabe1 (1Kyoto
Pharm. Univ., 2Fukuoka Inst. Health Environ. Sci.,3Tottori Pref. Inst. Pub.
Health Environ., 4Toyama Pref. Environ. Sci. Res. Center, 5Osaka City Inst.
Pub. Health Environ. Sci., 6Tottori Univ. 7Univ. Shizuoka)

P-2

Recent Change of Polycyclic Aromatic Hydrocarbon Concentrations in theJapan Sea and Changjiang River, China
۵Fumiya Makino1, Ning Tang1, Akira Toriba1, Masayuki Kunugi2,
Kazuichi Hayakawa1,2 (1Sch. Pharm., Kanazawa Univ., 2Institute of Natureand Environmental Technology, Kanazawa Univ.)

P-3

Mutagenicity of 1,2-naphthoquinone in the lung of mice۵Yasunobu Aoki1, Michiyo Matsumoto1, Rie Yanagisawa2, Michi Matsumoto1,
Daisuke Nakajima1 (1Center for Environmental Risk Research, 2Center for
Environmental Health Sciences, National Institute for Environmental Studies)

P-4

Effects of PM2.5 and PM10 on a mouse model of bronchial asthma
۵Takamichi Ichinose1, Seiichi Yoshida1, He Miao2 (1Oita Univ NHS, 2China
Medical Univ, CPH.)

P-5

Prediction of Nasal Absorption of Volatile Organic Compounds by
Computational ChemistryࠐHideto Jinno1, Toshiko Tanaka-Kagawa1, Maiko Tahara1, Yoko Kawahara1,
Kaori Mayumi1, Yoshiaki Ikarashi1, Nobumitsu Hanioka2 (1 National Instituteof Health Sciences, 2 Yokohama College of Pharmacy)

P-6

Gene expression changes in the neural stem cells by prenatal exposure totitanium dioxide nanoparticle
۵Misuzu Kotsugai1,2, Ken Tachibana2,3, Shotarou Kawazoe1,2, Kouji Ueda1,
Yusuke Shinkai2 , Masakazu Umezawa2, Ken Takeda2 (1Grad. School Pharm.
Sci., Tokyo Univ. Sci, 2Cent. Env. Health Next Gen., RIST, Tokyo Univ. Sci.
3 Nihon Pharm. Univ.)

−64−

P-7

Effect of prenatal exposure to carbon black nanoparticle on mouse fed with N-3
polyunsaturated fatty acids-deficient diet
۵Masayuki Nakamura1,2, Hiroshi Hori1,2, Masako Tabata1, Natsuko Kubota2,
Ken Takeda2, Masakazu Umezawa2 (1Fac. Pharm. Sci., Tokyo Univ. Sci., 2 Cent.
Env. Health Next Gen., RIST, Tokyo Univ. Sci.)

P-8

Prenatal exposure to PCB is negatively associated with insulin-like growth
factor 1 (IGF-1) in cord plasma۵Miyuki Iwai-Shimada1,2, Nozomi Tatsuta3, Kunihiko Nakai3,
Naoyuki Kurokawa4, Hiroshi Satoh3 and Akira Naganuma1 (1Grad. Sch.
Pharmaceut. Sci., Tohoku Univ., 2JSPS Research Fellow, 3Tohoku Univ. Grad.
School of Med., 4Miyagi Univ. of Edu.)

P-9

Indoor environmental dynamics of plasticizer phthalate esters: hydrolysis
products in house dust
۵Maiko Tahara, Toshiko Tanaka-Kagawa, Yoko Kawahara, Yoshiaki Ikarashi,
Hideto Jinno (Division of Environmental Chemistry, National Institute of
Health Sciences)

P-10

Evaluation of PCBs exposure via house dust
۵Toshiko Tanaka-Kagawa1㸪Maiko Tahara1㸪Naoki Iwata2㸪Takumi Takasuga2㸪
Yoko Kawahara1㸪
Kaori Mayumi1㸪
Yoshiaki Ikarashi1㸪
Hideto Jinno1 (1Natl. Inst.
Health Sci.㸪2Shimadzu Techno Res. Inc.)

P-11

Detection of plasticizers and organophosphorus flame retardants in residential
indoor environment
۵Shinji Takeuchi1, Kazuo Jin1, Masayuki Sato1, Satoshi Kobayashi1,
Hiroyuki Kojima1, Ikue Saito2, Hitoshi Uemura3, Toshiko Tanaka-Kagawa4,
Hideto Jinno4 (1Hokkaido Inst. Public Health, 2Tokyo Metropolitan Inst. Public
Health, 3Kanagawa Prefectural Inst. Public Health, 4National Inst. Health Sci.)

P-12

Oxidative stress response to the components of secondary organic aerosol inbronchial epithelial cells
۵ Tomohiro Ito, Kanae Bekki, Seishiro Hirano (National Institute forEnvironmental Studies)

Carcinogen

P-13

The human cytochrome P450(CYP) species involved in the formation of novelhydroxylated S-containing PCB metabolites
۵Takahiro Shima, Hitomi Nakai, Eri Ichiyma, Mizuho Nanzyo, Akihisa Toda,
Hiroaki Kuroki (Daiichi University of Pharmacy)

−65−

P-14

Functional interaction between cytochrome P450 3A4 (CYP3A4) andUDP-glucuronosyltransferase (UGT): allelic variant-dependent alteration of
UGT1A7 function by CYP3A4
۵Natsuki Egoshi1㸪Yuji Ishii1㸪Kousuke Kinoshita1, Hiroki Koba1,
Shin-ichi Ikushiro2㸪Kiyoshi Nagata3㸪Yasushi Yamazoe4㸪Peter I. Mackenzie5㸪
Hideyuki Yamada1 (1Grad Sch Pharmaceut Sci, Kyushu Univ.㸹2Fac Eng,
Toyama Prefectural Univ.㸹3 Tohoku Pharmaceut Univ.㸹4The Cabinet Office,
Government of Japan㸹 5Dep Clin Pharmacol, Flinders Medical Centre)

P-15

Exploring the mechanism of the hepatic tumor increase in the F2 maleoffspring born to F0 female mice gestationally exposed to arsenite
۵Keiko Nohara1, Kazuyuki Okamura1, Takehiro Suzuki1, Hikari Murai1,
Masuko Kobori2 (1Natl. Inst. for Environ. Studies, 2 Natl. Food Res. Inst., Natl.
Agr. and Food Res. Org.)

P-16

DNA methylation changes and the corresponding Fosb mRNA increase byarsenic in mouse hepatoma Hepa1c1c7 cells
۵Takehiro Suzuki, Keiko Nohara (Center for Environ. Health Sci., Natl. Inst.
Environ. Studies)Brain࣭Neural toxity

P-17

Effect of polycyclic aromatic hydrocarbons on neurite outgrowth in PC12 cells
۵Yuka Kinoshita, Ayaka Nakanishi, Akari Kudo, Noriko Sanada and
Ryoichi Kizu (Fac. Pharm. Sci., Doshisha Women’s College of Liberal Arts)

P-18

Mechanism of EAAT3 increased by mitochondrial complex inhibitors
۵Satoshi Adachi1, Yaichiro Kotake1,2, Tomomi Yamamoto1, Wako Sugeta1,
Shigeru Ohta1,2 (1Fac. Pharm. Sci., Hiroshima Univ., 2Grad. Sch. of Biomed. and
Health Sci., Hiroshima Univ.)

P-19

Reduced lysosomal function and impaired autophagy induced by low
concentration of Parkinson’s disease-related chemical۵Masatsugu Miyara1, 3, Yaichiro Kotake1, 2, Wataru Tokunaga2, Shigeru Ohta1, 2(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. of Pharmaceut.
Sci., Hiroshima Univ., 3JSPS Research Fellow)

P-20

Effects of Activation of AhR Signaling in Neurons on Migration and Morphology
۵Ding Yunjie1, Eiki Kimura1, Masaki Kakeyama1, 2, Chiharu Tohyama㸯(1Grad. Sch. of Med., Univ. of Tokyo, 2Grad. Sch. of Biomed. Sci., Nagasaki
Univ.)−66−

Endocrine disruptors

P-21

A novel mechanism for growth retardation produced by maternal exposure todioxin: a study focusing on growth hormone in perinatal pups
۵Yukiko Hattori, Tomoki Takeda, Misaki Fujii, Waka Izumoto, Yuji Ishii,
Hideyuki Yamada (Grad. Sch. Pharmaceut. Sci., Kyushu Univ.)

P-22

Mechanism by which dioxin reduces the maternal expression of prolactin
during the nursing periods and its effect on pup maturation.
۵Waka Izumoto, Tomoki Takeda, Misaki Fujii, Yukiko Hattori, Yuji Ishii,
Hideyuki Yamada (Fac. Pharmaceut. Sci., Kyushu Univ.)

P-23

Mechanism whereby maternal exposure to dioxin fixes the status of the lowered
expression of gonadotropin-releasing hormone in the offspring: an analysis
focusing on the metabolome.
۵ Kyoko Nishida, Tomoki Takeda, Yuji Ishii, Hideyuki Yamada (Fac.
Pharmaceut. Sci., Kyushu Univ.)

P-24

Mechanism underlying the dioxin-induced suppression of gonadal
steroidogenesis in fetuses: a study focusing on energy production.
۵Yuki Matsuo1, Akihisa Fujiki1, Takayuki Koga2, Tomoki Takeda1, Yuji Ishii1,
Hideyuki Yamada1 (1Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 2Daiichi Univ.
Pharm.)

P-25

Mice lacking Ah receptor in the adipose tissue are resistant to high fat
diet-induced adipose tissue inflammation and diabetes.
۵ Yuki Kasakura, Taira Wada, Shigeki Shimba (Dep. Health Sci. Sch.
Pharmacy, Nihon Univ.)



P-26

Agonistic activity of synthetic fragrances against PXR, CAR, PPARǂ and AhR
in reporter gene assays
۵Yoko Watanabe1,2, Hiroyuki Kojima3, Naoto Uramaru1, Nariaki Fujimoto4,
Kazumi Sugihara5, Kouichi Yoshinari6,7, Shigeru Ohta2, Shigeyuki Kitamura1(1Nihon Pharmaceut. Univ., 2Grad. Sch. Biomed. Health Sci., Hiroshima Univ.,
3Hokkaido Inst. Pub. Health, 4Grad. Sch. Biomed. Health Sci., Hiroshima Univ.,
5R. I. R. B. M., Hiroshima Univ., 6Sch. Pharmaceut. Sci., Univ. Shizuoka, 7Grad.
Sch. Pharmaceut. Sci., Tohoku Univ.)

P-27

Effects of thyroid hormone analogues on transcriptional activities via pregnane
X receptor and constitutive androstane receptor
۵Ryo Shimizu1, Yoko Watanabe2, Naoto Uramaru2, Hiroyuki Kojima3,
Shinji Takeuchi3, Hiroaki Kuroki4, Shigeru Ohta5, Shigeyuki Kitamura2,
Kazumi Sugihara1 (1Fac. Pharmaceut. Sci., Hiroshima Internatl. Univ., 2Nihon
Pharmaceut. Univ., 3Hokkaido Inst. Pub. Health, 4Daiichi Univ. Pharm., 5Grad.
Sch. Biomed. Health Sci., Hiroshima Univ.)

−67−

P-28

Sex differences of aldehyde oxidase in mice liver and the effect of chemicals on theexpression
۵Kazumi SUGIHARA1, Akiho OKAZAKI1, Yuka AKIMOTO1, Yoshitaka TAYAMA1,
Shiduko MAEDA1, Seigo SANOH2, Shigeyuki KITAMURA3, Shigeru OHTA2 (1Facul.
Pharm. Sci, Hiroshima International Univ., 2Grad. Sch. Biomed. Health Sci., Hiroshima
Univ., 3Nihon Pharm. Univ.)

P-29

Agonistic and antagonistic activities of environmental chemicals for thyroid
hormone receptors in frogs
۵Seigo Sanoh1, Naoki Nakamura1, Ken-ichi Suzuki2, Keiko Kashiwagi3,
Hideki Hanada3, Takashi Yamamoto2, Tadashi Shinkai4, Kazumi Sugihara5,
Nariaki Fujimoto6, Shigeyuki Kitamura7, Akihiko Kashiwagi2, Shigeru Ohta1(1Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Math. Life Sci., Grad. Sch.
Sci., Hiroshima Univ., 3 Inst. Amphibian Biol., Grad. Sch. Sci., Hiroshima Univ.,
4Shibaura Inst. Technol., 5Fac. Pharm. Sci., Hiroshima International Univ.,
6R.I.R.B.M., Hiroshima Univ., 7Nihon Pharmaceutical Univ.)

P-30

Cellular toxicity of bisphenol AF (BPAF), a new-generation bisphenol, throughERȕ۵Miki Tokuyasu1, Hiroyuki Okazaki1, Eriko Ikeda1, Hiroyuki Ishii1,
Kazuhiro Kakizoe1, Taichi Himeno1, Aya Taniguchi1, Yasushi Yoshioka1,
Shuso Takeda2, Koichi Haraguchi1, Kazuhito Watanabe3, Masufumi Takiguchi2,
Hironori Aramaki1 (1Daiichi Univ. Pharm., 2Fac. Pharm. Sci., Hiroshima Int’l
Univ., 3 Fac. Pharm. Sci., Hokuriku Univ.)

P-31

ǻ9-THC-mediated uterine dysfunction: implications for the disorder of ERĮ
function and induction of MMP-1
Taichi Himeno1, ۵Hiroyuki Okazaki1, Eriko Ikeda1, Kazuhiro Kakizoe1,
Yasushi Yoshioka1, Miki Tokuyasu1, Aya Taniguchi1, Hiroyuki Ishii1, Shuso Takeda2,
Kazuhito Watanabe3, Hironori Aramaki1 (1Daiichi Univ. Pharm., 2 Fac. of Pharm. Sci.,
Hiroshima Int’l Univ., 3Fac. of Pharm. Sci., Hokuriku Univ.)

P-32

Combination effects of benzimidazoles on the chemical ligand
mediated-activation of AhR in human hepatoma cell lines.
۵Seiko Nagasawa1, Masashi Sekimoto1, Aika Tasaki1, Akiyoshi Nishikawa2,
Takashi Uemura2, Kiyomitsu Nemoto1, Kouichi Yoshinari1, Msakuni Degawa1(1Dept. Mol. Toxicol., Sch. Pharm. Sci., Univ, Shizuoka., 2Natl. Inst. Health Sci.)

Foods and Pesticides

P-33

Identification and Characterization of Human Vitamin K Converting Enzyme
Gene Promoter
۵Yoshihisa Hirota1,2, Kimie Nakagawa2, Masato Watanabe2,
Nobuaki Funahashi2, Toshio Okano2 (1Faculty of Pharmaceutical Sciences,
Suzuka University of Medical Science, 2Department of Hygienic Sciences, Kobe
Pharmaceutical University)

−68−

P-34

Effect of tea catechin on androgen-dependent transcriptional activation
۵Noriko Sanada, Nozomi Sakurai, Yumi Fujii, Yuka Kinoshita, Ryoichi Kizu
(Fac. Pharmaceut. Sci., Doshisha Women’s Coll. Liberal Arts)

P-35

Analysis of 4Ļ-O-methylpyridoxine and its metabolites in urine of patients with
“Gin-nan food poisoning”
۵Mika Ishikawa, Tomoka Takahashi㸪Daisuke Kobayashi, Teruki Yoshimura,
Keiji Wada (School of Pharmaceutical Sciences, Health Sciences University of
Hokkaido)

P-36

Cytotoxicity of clay nano-particles
۵Ryutarou Nagata, Katsuhiro Isoda, Anna Otsuka, Tomoya Hasegawa,
Isao Ishida ( Fac. Pharmaceut. Sci., Teikyo Heisei Univ.)

P-37

Reductive metabolism of raspberry ketone to rhododendrol in rats
۵Kasumi Sakamoto, Yoko Watanabe, Naoto Uramaru, Sigeyuki Kitamura(Nihon Pharmaceut. Univ.)

P-38

Protection from arsenite-induced toxicity by electrophiles from Coriandrum

sativum L. leaf extract in HepG2 cells

۵Yumi Abiko1, Mai Mizokawa2, Yoshito Kumagai1,2 (1Fac. Med., Univ. Tsukuba,
2Grad. Sch. Life and Env. Sci., Univ. Tsukuba)

MetalsP-39

Role of MerC, MerE, MerF, MerT, and/or MerP in Resistance to Mercurials
and the Transport of Mercurials in Escherichia coli
۵Yuka Sone, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono(Sch. Pharm. Sci., Kitasato Univ.)

P-40

Studies on inhibitory effects of saponins to methylmercury toxicity in Caco-2
cells
۵Ryosuke Nakamura, Yuka Sone, Yasukazu Takanezawa, Tatsuya Shirahata,
Yoshinori Kobayashi, Masako Kiyono (Sch. Pharm., Kitasato Univ.)

P-41

Distribution of mercury and selenium in rats administered inorganic mercury
and selenocyanate or selenite
۵Mari Uchida, Ayumu Kitazato, Yasumi Anan, Yasumitsu Ogra (Showa
Pharm. Univ.)

P-42

Interaction between selenium compounds and inorganic mercury in culturedcells۵Satomi Usui, Yasumi Anan, Yasumitsu Ogra (Showa Pharm. Univ.)

−69−

P-43

Induction of aldose reductase expression in cultured human brain
microvascular pericytes after exposure to methylmercury
۵Tomoko Sasaoka1, Eiko Yoshida1, Chika Yamamoto2 ,Toshiyuki Kaji1 (1Fac. of
Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Toho Univ.)

P-44

Mechanisms underlying VEGF induction by methylmercury in cultured
human brain microvascular pericytes
۵Kenta Sakurai1, Eiko Yoshida1, Chika Yamamoto2 ,Toshiyuki Kaji1 (1Fac. of
Pharm. Sci., Tokyo Univ.of Sci., 2Fac. of Pharm. Sci., Toho Univ.)

P-45

Methylmercury toxicity in the fibrinolytic system of cultured human brain
microvascular endothelial cells
۵Miho Tanaka1, Masaru Kurita1, Eiko Yoshida1, Chika Yamamoto2,
Toshiyuki Kaji1 (1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci.,
Toho Univ.)

P-46

Effect on the fetal expression of pituitary, gonadal and adrenal hormones bygiving methylmercury-containing water to pregnant rats
۵Tomoki Takeda1, Yukiko Hattori1, Yudai Kariyazono1, Masatake Fujimura2,
Yuji Ishii1, Hideyuki Yamada1 (1Grad. Sch. Pharmaceut. Sci., Kyushu Univ.,
2Toxicol. Pathol. Sec., Natl. Inst. Minamata Disease)

P-47

Involvement of LAMTOR complex in methylmercury-induced autophagy
۵Kento Matsuda, Tsutomu Takahashi, Gi-Wook Hwang, Akira Naganuma(Sch. of Pharm. Sci., Tohoku Univ.)

P-48

MRI approach to detect expansion of mice cerebral ventricles by
methylmercury
۵Ryohei Takahashi1, Kouichi Itoh2, Yasuhiro Ishihara1, Megumi Yamamoto3㸪
Atsuhiko Ishida1, Takeshi Yamazaki1 (1Dept Integra Art & Sci, Hiroshima Univ.,
2Kagawa Sch of Pharm Sci, Tokushima Bunri Univ., 3National Institute for
Minamata Disease.)

P-49

Cadmium activates serum/glucocorticoid regulated kinase 1 in HK-2 humanrenal proximal tubular cells
۵ Takamitsu Miyayama, Masato Matsuoka (Sch. Med., Tokyo Women’s
Medical Univ.)

P-50

Involvement of metal transporters in the mechanisms underlying protection byzinc against cadmium cytotoxicity in vascular endothelial cells
۵Akane Uehara1, Eiko Yoshida1, Chika Yamamoto2, Toshiyuki Kaji1 (1 Fac. of
Pharm. Sci., Tokyo Univ. of Sci., 2 Fac. of Pharm. Sci., Toho Univ.)

P-51

Effect of long-term exposure to cadmium on metallothionein expression inmouse lymphosarcoma P1798 cells
۵Fuyuri Fukumoto, Ryo Kimura, Takuomi Hosaka, Tomoki Kimura (Fac.
Pharm. Sci., Setsunan Univ.)

−70−

P-52

Comprehensive analysis of a transcription factor involved in expression of
cadmium-induced renal toxicity
۵Maki Tokumoto, Jin-Yong Lee, Masahiko Satoh (Sch. of Pharm., Aichi
Gakuin Univ.)

P-53

High-speed treadmill running exercise is a host-related risk factor forincreasing tissue accumulation of oral cadmium in mice۵Kyong-Son Min, Rie Mihana, Ayumi Sumi, Kana Chahara, Keita Yamada,Fumitoshi Sakazaki (Lab. Toxicol., Fac. Pharm., Osaka Ohtani Univ.)

P-54

Changes in expression of lactic acid-related genes in manganese-resistant cells
۵ Hitomi Fujishiro, Kimiko Jyo, Seiichiro Himeno (Fac. Pharm. Sci.,
Tokushima Bunri Univ.)

P-55

Effects of BubR1 on the accumulation of mitotic cells induced by Thio-DMA
۵Yu Imai, Kayoko Kita, Toshihide Suzuki, Takafumi Ochi (Fac. Pharm. Sci.,
Teikyo Univ.)

P-56

Tissue distribution and excretion of arsenic and selenium following
co-administration of diphenylarsinic acid or arsenate with selenite in rats
۵Yayoi Kobayashi, Seishiro Hirano (National Institute for Environmental
Studies)

P-57

Specificity of As3MT on metalloid methylation
۵Daiki Katsuta, Maki Tokumoto, Yasumi Anan, Yasumitsu Ogra (Lab. Chem.
Toxicol. Environ. Health, Showa Pharm. Univ.)

P-58

Comparison in the distribution of inorganic and organic tellurium compounds
in rats۵Yasuyo Tsukamoto, Yasumi Anan, Taisuke Atarashi, Yui Ebata,
Yasumitsu Ogra (Showa Pharma.Univ.)

P-59

Ovarian functions modify triphenyltin-induced toxicity in adult female mice۵Yuki Otsuka, Akira Aoki, Tsuyoshi Nakanishi, Hisamitsu Nagase (Gifu
Pharm. Univ.)

P-60

Potential protection of major urinary protein 1 against organotins-induced
toxicity in mice۵Akira Aoki, Yuki Otsuka, Tsuyoshi Nakanishi, Nagase Hisamitsu (Gifu
Pharm. Univ.)

P-61

IDH3-mediated G2/M arrest induced by organotin compound
۵Miki Asanagi1,2, Shigeru Yamada2, Yaichiro Kotake 3, Hiroshi Itagaki 2,
Yuko Sekino 1, Yasunari Kanda 1 (1Div. Pharmacol., NIHS, 2Dept. Mat. Sci. Eng.,
Grad. Sch. Eng., Yokohama Natl. Univ., 3Grad. Sch. Biomed. Health. Sci.,
Hiroshima Univ.)
−71−

P-62

Effects of heavy metals on MMP2 and MMP9 activity
۵Noriko Nishitani, Shuso Takeda, Masufumi Takiguchi (Fac. Pharmaceut. Sci.,
Hiroshima Intl. Univ.)

P-63

The effect of dihydropyrazine on the expression of zinc transporter mRNA in
HepG2 cells
۵Mutsumi Kobayashi, Iyo Mitsudome, Takumi Ishida, Shinji Takechi (Fac.
Pharmaceut. Sci., Sojo Univ.)

P-64

Up-regulation of ZIP8 expression by TGF-ǃ1 in cultured vascular endothelial
cells۵Masahiro Shimomura1, Eiko Yoshida1, Chika Yamamoto2, Toshiyuki Kaji1(1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Toho Univ.)

P-65

Search for genes involved in the cytotoxicity of organobismuth compounds
۵Shizuka Nakasako1, Kumiko Kohri1, Chika Yamamoto 2,3, Shuji Yashuike 2,4,
Toshiyuki Kaji 1,2 (1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2RIST, BOM, Tokyo
Univ. of Sci., 3Fac. of Pharm. Sci., Toho Univ., 4Fac. Pharm. Sci., Aichi Univ.)

P-66

Clarification of mechanisms underlying metallothionein gene expression in
vascular endothelial cells using an organoantimony compound۵Masaki Murakami1, Tomoya Fujie1, Tomoki Kimura2,3, Yasuyuki Fujiwara3,4,
Shuji Yasuike3,5, Chika Yamamoto3,6, Toshiyuki Kaji1,3 (1Fac. of Pharm. Sci.,
Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Setsunan Univ., 3RIST, BOM, Tokyo
Univ. of Sci., 4Sch. of Pharm., Tokyo Univ. of Pharm. & Life Sci., 5Sch. Pharm.,
Aichi Gakuin Univ., 6Fac. of Pharm. Sci., Toho Univ.)

P-67

An organoantimony compound that selectively induces biglycan synthesis invascular smooth muscle cells
۵Mizuho Kobayashi1, Shuji Yasuike2, Toshiyuki Kaji3, Chika Yamamoto1 (1Fac.
of Pharm. Sci., Toho Univ., 2Fac. of Pharm. Sci., Aichi Gakuin Univ., 3Fac. of
Pharm. Sci., Tokyo Univ. of Sci.)

P-68

Clarification of mechanism underlying metallothionein induction in vascularendothelial cells using a copper complex
۵Tomoya Fujie1, Hiroshi Naka2, 3, Yasuyuki Fujiwara3, 4, Toshiyuki Kaji1, 3 (1Fac.
Pharm. Sci., Tokyo Univ. of Sci., 2Res. Center Mater. Sci., Nagoya Univ., 3RIST,
BOM, Tokyo Univ. of Sci., 4Sch. Pharm., Tokyo Univ. Pharm. & Life Sci.)

P-69

Zinc complexes that modulate the fibrinolytic activity of vascular endothelial
cells۵Manami Nakagawa1, Takehiro Nakamura2, Toshiyuki Kaji2,
Chika Yamamoto1 (1Fac. of Pharm. Sci., Toho Univ., 2Fac. of Pharm. Sci., Tokyo
Univ. of Sci.)

−72−

P-70

Screening of Copper and Zinc response genes in C. elegans cultured by liquidsynthetic medium
۵Nobuaki Tominaga1, Riho Kabashima1, Akemi Yamaguchi1, Masaya Uchida2,
Koji Arizono3 (1Dept. Chem. & Biol. Eng., Ariake Natl. College Technol.,2Ecogenomics Inc, 3Fac. Symbio. Environ. Studies, Kumamoto Pref. Univ.)

P-71

Adverse effect of nano-sized titanium P25 on testicular function
۵Nobuhiko Miura, Katsumi Ohtani, Tetsuya Suzuki, Yukie Yanagiba,
Rieko Hojo, Megumi Suda, Rui-Sheng Wang (Natl Inst Occu Safety Health)

P-72

Acute toxicity test of 50 Metals to Daphnia magna۵ Akira Okamoto1, Norihisa Tatarazako1,2 (1Department of Natural
Environmental Studies, The University of Tokyo, 2NIES.)

Immunotoxicity࣭Infectious diseases

P-73

Regulatory mechanism of HIV uncoating by ERK2 and exploring of anti-HIV
agents for the control of HIV infection
۵ Takeo Dochi1, Nobutoki Takamune2, Shogo Misumi3 (1Grad. Sch.
Pharmaceut. Sci., Kumamoto Univ., 2KICO, Kumamoto Univ., 3Grad. Sch. Life
Sci., Kumamoto Univ.)

P-74

Cellular GAPDH restricts efficient priming of HIV reverse transcription
۵Naoki Kishimoto1, Ayano Onitsuka1, Nobutoki Takamune2, Shogo Misumi3(1Grad. Sch. Pharmaceut. Sci., Kumamoto Univ., 2KICO, Kumamoto Univ.,
3Grad. Sch. Life Sci., Kumamoto Univ.)

P-75

Effect of cytoplasmic distribution of Hepatitis C virus core protein on inductionof unfolded protein response and lipid droplet formation: analysis using
budding yeast model system
۵Shingo Iwasa, Kenta Iwai, Shusuke Kuge (Dept. of Microbiology, Tohoku
Pharmaceutical University)

P-76

Cytokine expressions in the sensitization phase of mouse active cutaneous
anaphylaxis
۵ Fumitoshi Sakazaki, Kazuya Tanabe, Shota Kanzaki, Keita Yamada,Kyong-Son Min (Lab. Toxicol., Fac. Pharm., Osaka Ohtani Univ.)

P-77

Effect of oxidized olive oil on mouse spleen cells and peritoneal macrophages
۵Hirofumi Ogino, Ai Minami, Takahiro Nakajima, Yoko Oka,
Tomohiro Arakawa, Tomofumi Okuno, Hitoshi Ueno (Fac. Pharmaceut. Sci.,
Setsunan Univ.)−73−

Oxidative stress

P-78

Role of mitSMase in mitochondrial dysfunction-induced cell death۵Takeshi Kumagai, Naoe Nishimura, Nozomi Abe, Eri Toyama,
Yasuhito Nakagawa, Hirotaka Imai (Sch. of Pharm., Kitasato Univ.)

P-79

Role of eukaryotic translation initiation factor 5 in reduction of toxicity ofhydrogen peroxide
۵Tsutomu Takahashi, Yuusaku Konno, Junxuan Zhu, Gi-Wook Hwang,
Akira Naganuma (Grad. Sch. of Pharm. Sci., Tohoku Univ.)

P-80

Effect of phenol red on the differentiation of metallothionein-null preadipocytes
۵Shinya SUZUKI, Rika MIYAI, Takafumi OTONARI, Kazutoshi MORI,
Tomoyuki SANO, Yoshito KADOTA, Takashige KAWAKAMI (Department of
Public Health, Faculty of Pharmaceutical Science, TokushimaBunri University)

P-81

Antioxidant activity and induction of Nrf2-ARE/HO-1 by marine carotenoids,
fucoxanthin and fucoxanthinol۵ Miki Sonamoto, Masatsugu Uehara, Junsei Taira (Department of
Bioresource Technology, Okinawa National College of Technology)

P-82

Study on the role of AhR in the induction of HO-1 by xanthohumol
۵Takayuki Nakahama, Yuichiro Kanno, Roko Aoki, Kayo Sakamoto,
Chihiro Takahashi, Yousuke Makino, Yoshio Inouye (Department ofEnvironmental Hygiene, Faculty of Pharmaceutical Sciences, Toho University)

Cellular responses

P-83

Reactive sulfur species and reactive oxygen species-mediated activation ofelectrophilic signaling caused by 1,2-naphthoquinone
۵Yasuhiro Shinkai1,2, Takashi Miura2, Hidenao Kakehashi2, Takaaki Akaike3,
Yoshito Kumagai1,2 (1Faculty of Med., Univ. of Tsukuba, 2Grad. School of Comp.
Human Sci., Univ. of Tsukuba, 3Sch. of Med., Tohoku Univ.)

P-84

Macrophage-recognition of modified-LDL through macrophage surface receptor
nucleolin
۵Yoshihiro Tachibana1, Yukari Ohminato1, Yuichi Miki1, Kazuya Hirano2,
Masatoshi Beppu1, Yasuyuki Fujiwara1 (1Tokyo University of Pharmacy and Life
Science, 2Takasaki University of Health and Welfare)P-85

Fisetin inhibits lipopolysaccharide-induced RANKL expression in MC3T3-E1
cells
۵Yuta Abe, Michiaki Kiriu, Hiroyuki Kaneki, Shigeki Mizuochi, Hayao Ide,
Chika Yamamoto (Fac. of Pharm. Sci., Toho Univ.)

−74−

P-86

ǻ9-Tetrahydrocannabinol-mediated activation of PPARĮ: implication for the

P-87

BKA, an apoptosis inhibitor: a novel utility of BKA as a PPARȖ-selective
activator
۵Aya Taniguchi1, Eriko Ikeda1, Shuso Takeda2, Miki Tokuyasu1,
Hiroyuki Ishii1, Yasushi Yoshioka1, Hajime Nishimura1, Hiroyuki Okazaki1,
Kenji Matsumoto3, Shindo Mitsuru3, Hironori Aramaki1 (1Daiichi Univ. Pharm.,
2Fac. Pharm. Sci., Hiroshima Int’l Univ., 3IMCE, Kyushu Univ.)

P-88

Regulatory mechanism of detoxification and excretion of bile acids by themolecular clock system
۵Kenshin Yoshida, Taira Wada, Shigeki Shimba  (Sch. Pharmacy, Nihon
Univ.)

P-89

Effect on STAT3 signal pathway of a novel anti-cancer stem cell compoundisolated from Saururus chinensis
۵Naoya Yamashita1, Yuichiro Kanno1, Chihiro Sato1, Masashi Wakai2,
Shinpei Endo2, Wei Li1, Kazuo Koike1, Yoshihisa Asada2, Yoshio Inouye1 (1Fac.
Pharmaceut. Sci., Toho Univ., 2 Fac. Pharmaceut. Sci., Tokyo Univ., Sci,.)

P-90

The role of AhR in the spheroid formation by prostate cancer cells under the
non-adherent culture conditions
۵Ryohei Budo, Yuichiro Kanno, Yoshio Inouye (Fac. Pharmaceut. Sci., Toho Univ.)

P-91

Relationship between the gene expression of selenoproteins and the growth
inhibition of human lung cancer cells by selenium compounds
۵Tomofumi Okuno, Ayumi Kitagaki, Eri Honda, Minori Nomura,
Hirofumi Ogino, Tomohiro Arakawa, Hitoshi Ueno (Fac. Pharmaceut. Sci.,
Setsunan Univ.)

P-92

Effect of selenomethionine on the inflammatory mediator expression in
RAW264.7 macrophages
۵Tomohiro Arakawa, Mayuko Okada, Hirofumi Ogino, Tomofumi Okuno,
Hitoshi Ueno (Fac. Pharmaceut. Sci., Setsunan Univ.)

P-93

Interaction between nuclear receptor CAR and PRMT5
۵Yuichiro Kanno, Jun Inajima, Sayaka Kato, Chikako Tokumoto, Yuki Kure,
Yoshio Inouye (Faculty of Pharmaceutical Sciences, Toho-University)

P-94

Isolation and characterization of ERǂ, ǃ, and PXR agonists from Euphrobia

involvement of induced levels of PPARĮ
Yasushi Yoshioka1, ۵Eriko Ikeda1, Shuso Takeda2, Hiroyuki Ishii1,
Hajime Nishimura1, Kazuhito Watanabe3, Hironori Aramaki1 (1Daiichi Univ.
Pharm., 2Fac. Pharm. Sci., Hiroshima Int’l Univ., 3Fac. Pharm. Sci., Hokuriku
Univ.)

fischeriana

۵Tomofumi Yatsu, Yuichiro Kanno, Michiru Mochizuki, Xinzhu Kuang, Wei Li,
Kazuo Koike and Yoshio Inouye.(Fac. Pharm. Sci., Toho Univ.)

−75−

P-95

DNA adduct formation in mouse embryonic stem cells leading to loss ofpluripotency and induction of apoptosis
۵ Misaki Wakahara1, Takao Tobe1, Masahiro Fujimura1, Hiroya Muro1,
Yoshinori Okamoto1, Koji Ueda1, Tatsuyuki Takada2, Nakao Kojima1 (1Fac. of
Pharm, Meijo Univ; 2Dept. of Pharm. Sci, Ritsumeikan Univ.)

P-96

p53-Independent cell death in mouse embryonic stem cells exposed by UV۵Yuki Shimizu1, Takao Tobe1, Yoshinori Okamoto1, Koji Ueda1,
Tatsuyuki Takada2, Nakao Kojima1 (1Fac. of Pharm., Meijo Univ.; 2Dept. of
Pharm. Sci., Ritsumeikan Univ.)

P-97

Lower concentrations of organotin induce eukaryotic initiation factor-2 (eIF2)
activation independent of unfolded protein response (UPR)۵Kyoichi Masuda1, Yaichiro Kotake1,2, Midori Isomura1, Tomoka Okamura1,
Shigeru Ohta1,2 (1Fac. of Pharm. Sci., Hiroshima Univ., 2Grad. Sch. of Biomed.
Sci., Hiroshima Univ.)

P-98

Function of a pseudokinase TRB1 as a negative regulator of TGF-ǃ signaling۵Miki Sawanaka, Yuka Itoh, Yasumichi Inoue, Hidetoshi Hayashi (Grad. Sch.
Pharmaceut. Sci., Nagoya City Univ.)

BiochemistryP-99

NPC1L1 plays important role in Į-Tocopherol uptake
۵Jun Kamishikiryou, Misaki Haraguchi, Hiroe Narahara, Naoya Matsumoto,
Narumi Sugihara (Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ.)

P-100

Role of hepatic PPARȖ in LXRĮ-associated fat accumulation
۵Daisuke Aibara1, Kimihiko Matsusue1, Kohei Matsuo1, Soichi Takiguchi2,
Shigeru Yamano1 (1Faculty of Pharmaceutical Science, Fukuoka University,
2Insutitute for Clinical Research, National Kyushu Cancer Center)P-101

PXR activation accelerates the growth factor-dependent hepatocyte
proliferation
۵Taiki Abe1,2, Ryota Shizu1, Atsushi Matsuzawa1, Kouichi Yoshinari1,2 (1Grad.
Sch. Pharmaceut. Sci., Tohoku Univ., 2Sch. Pharmaceut. Sci. Univ. Shizuoka)

P-102

Recognition of maleyl-BSA by macrophage surface receptor nucleolin۵ Keisuke Koyama1, Haruna Kurusu1, Yuichi Miki1, Kazuya Hirano2,
Masatoshi Beppu1, Yasuyuki Fujiwara1 (1Tokyo University of Pharmacy andLife Science, 2Takasaki University of Health and Welfare)P-103

Effect of gene deletion of two prostaglandin terminal synthases, PGIS andmPGES-1 on adiposity in mice۵Yuka Sasaki1, Yuri Yamakawa1, Moe Akatsu1, Chieko Yokoyama2,
Shuntaro Hara1 (1Sch. of Pharmacy, Showa Univ., 2Kanagawa Institute ofTechnology)−76−

P-104

Biochemical analysis of transcriptional factor YY1-Rb complex in smoothmuscle cells
۵Makoto Hiromura1, Yasuko Yamamoto2, Takayuki Koga3,
Minehiro Moriyama2, Anny Usheva4, Akihisa Toda1 (1Lab. Hygienic Chem.
Daiichi Univ. Pharm., 2Lab. Adv. Pharm. Daiichi Univ. Pharm., 3DIRC. Pharm.
Daiichi Univ. Pharm., 4Dept. Med. Harvard Med. Sch.)

P-105

Biglycan suppresses syndecan-4 expression mediated by ALK5 signaling
cooperatively with TGF-ǃ1
۵Takato Hara, Toshiyuki Kaji (Fac. of Pharm. Sci., Tokyo Univ. of Sci.)

P-106

Inhibition of Acyl-CoA synthetase activity perturbs fatty acid metabolism
۵Hiroshi Kuwata, Hiroaki Shimada, Tomohiro Shoji, Arisa Fukushima,
Shuntaro Hara (Sch. Pharm, Showa Univ.)

P-107

Transcriptional regulation of BMP antagonist gremlin
۵Naoki Machida, Kaori Nishida, Kaori Misu, Yusuke Izumi, Shigeki Mizuochi,
Hiroyuki Kaneki, Hayao Ide and Chika Yamamoto (Fac. of Pharm. Sci., Toho
Univ.)

P-108

Expression of Smurf as an E3 ubiquitin ligase increases with aging in humanosteoblasts۵Kanako Sakai, Hiroyuki Kaneki, Tomoe kaitsuka, Michiaki Kiriu,
Shigeki Mizuochi, Hayao Ide, Chika Yamamoto (Fac. of Pharm. Sci., Toho Univ.)

P-109

Breed-difference in serum testosterone level in pigs: Comparison of the gene
expression levels responsible for testosterone production in the testis۵Misaki Kojima1, Jun-ichi Suto1, Masakuni Degawa2 (1Natl. Inst. Agrobiol.
Sci., 2Sch. Pharm.. Sci., Shizuoka Univ.)

P-110

Characterization of Sexual Function in Vitamin D Receptor Null Mutant Mice
۵Maya Kamao, Maiko Ota, Haruka Igarashi, Chigusa Tanaka, Akiko Nishi,
Kanami Nishimura, Manaka Hayashi, Toshio Okano (Dept. of Hygienic Sci.,
Kobe Pharm. Univ.)

P-111

Multifunctional zinc-finger domain of metal dependent transcription factor
MTF-1
۵Tae Shimoyama1, Yoichi Osada1, Kaoru Suzuki2, Shinji Koizumi2,
Otsuka Fuminori1 (1Fac. Pharma-Sci., Teikyo Univ., 2JNIOSH)

P-112

Effect of diet-induced obesity gene expression of ketone body-utilizing enzymes
in brown adipose tissue
۵Masahiro Yamasaki1, Shotaro Ozaki1, Satoshi Kitamura1, Shinya Hasegawa1,
Tetsuya Fukui2 (1Dept. of Health chemistry, Sch. of pharm., Hoshi Univ.,
2Ritsumeikan Univ.)−77−

P-113

Role of ketone body-utilizing enzyme during neuronal differentiation
۵Shinya Hasegawa1, Tetsuya Fukui2, Masahiro Yamasaki1 (1 Dept. of HealthChem., Sch. of Pharm. Sci., Hoshi Univ., 2Dept. of Pharm., Coll. of Pharm. Sci.,
Ritsumeikan Univ. )Preventive Pharmacology

P-114

Anti-invasive mechanism of retinoid derivatives
۵Masahiko Imai, Kotaro Takeda, Chuan Li, and Noriko Takahashi (LPC, IMC,
Hoshi University)

P-115

Influence on obesity by Momordica charantia extract
۵Makiko Hosaka, Takaya Kumaoka, Masahiko Imai, and Noriko Takahashi(Hoshi University)

P-116

Screening of inhibitors against tyrosinase activity
۵Noriko Takahashi, Masahiko Imai, and Yu Komori (LPC, IMC, Hoshi
University)

P-117

Isolation and identification of anti-mutagens in green tea against
mutagenic/carcinogenic 1-nitropyrene
۵ Tomohiro Hasei, Megumi Fujihashi, Fumitaka Shinkai, Yuki Kawai,
Tetsushi Watanabe (Kyoto Pharm. Univ.)

P-118

Estrogen receptor dependent anti-proliferation effects of soy isoflavones against
breast cancer cells
۵Takao Tobe, Tomonari Sumiyoshi, Erika Tsuchiya, Ayano Sindo, Tomoko Hibi,
Yoshinori Okamoto, Koji Ueda, Nakao Kojima (Fac. of Pharm., Meijo Univ.)

P-119

A survey of smoking status and attitudes towards smoking in university
students- Importance of health education which can sever social nicotine
dependence ۵Takako Yamaguchi, Mika Sato, Yasuko Morimoto, Hiroyasu Yamazaki (Fac.
Pharm. Sci., Kobe Gakuin Univ.)

Analytical ChemistryP-120

Development of analytical method for catechins using fluorescencederivatization and its application to green tea
۵Tomohiro Kishi, Nanami Iwashita, Kunihiko Matsushima, Yuya Deguchi,
Megumi Nagaoka and Hiroaki Nagaoka(Fac. Pharmaceut. Sci., Nagasaki
International Univ.)−78−

Others

P-121

Studies on mechanism underlying adriamycin-induced cytotoxicity by
reduction of HMG-CoA synthase activity
۵Junxuan Zhu, Tsutomu Takahashi, Gi-Wook Hwang, Akira Naganuma(Grad. Sch. of Pharm. Sci., Tohoku Univ.)

P-122

Analysis of NASH pathogenesis in p62:Nrf2-DKO mouse by using MRI
۵Miho Ikeuchi, Kentaro Akiyama, Eiji Warabi, Junichi Shoda (Faculty of
Medicine, University of Tsukuba)

P-123

Lifespan of Metallothionein Knockout mice.
۵Yoshito Kadota, Yuriko Toriuchi, Yuto Mizuno, Yuka Aki, Satoshi Takasaki,
Takashige Kawakami, Masao Sato, and Shinya Suzuki (Fac. Pharmaceut. Sci.,
Tokushima Bunri Univ.)

P-124

Social behavior of mice under group-housed conditions analyzed by a newly
developed behavior analysis system
۵Waka Ujita1, Nozomi Endo1, Chiharu Tohyama1, Masaki Kakeyama 1,2(1 Lab. Env. Health Sci., Grad. Sch. of Med., The Univ. of Tokyo, 2 Dep.
Neurobiol. and Behav., Grad. Sch. of Biomedical Sciences, Nagasaki Univ.)

P-125

Metabolism of major cannabinoids by human brain microsomes۵Kazuhito Watanabe1, Misa Miyamoto1, Keisuke Iwata1, Noriyuki Usami1,
Satoshi Yamaori2, Koutarou Hasegawa3, Kanako Watanabe3, Osamu Suzuki3,
Ikuo Yamamoto4 (1Fac. Pharmaceut. Sci., Hokuriku Univ., 2Shinshu Univ.
Hosp., 3Hamamatsu Univ. Sch. Med., 4Kyushu Univ. Health Welfare)P-126

In vivo metabolism of 2,2’-dimethoxy-BB80 detected from marine biota in rats
۵Eri Nishimura1,3, Chiho Ohta2, Koichi Haraguchi3, Tetsuya Endo4,
Yoshihisa Kato5, Kenta Yamamoto2, Nobuyuki Koga1,2 (1Graduate School of
Nakamura Gakuen Univ., 2Nakamura Gakuen Univ., 3Daiichi College of Pharm.
Sci., 4Tokushima Bunri Univ., 5Health Sci. Univ. of Hokkaido)

P-127

Effect of nobiletin on transport of N-acetyl mesalazine through Caco-2 cellmonolayers
۵Narumi Sugihara, Saori Kurata, Kaori Yoshioka, Jun Kamishikiryou (Fac.
Pharm. Pharmaceut. Sci., Fukuyama Univ.)

P-128

Mechanism of Skin Lesions Induced by Antimicrotubule agents Extravasation
۵Masaki Takaishi1, Michiko Kosugiyama1, Takumi Sagawa1,
Masahiro Karino1, Kaori Ikeda1, Ryuma Kikuchi1, Toshiaki Takeda2,
Satoshi Asano1 (1School of Pharmacy, International Univ. of Health and Welfare,
2Fac. of Nursing, Iwate Prefectural Univ.)−79−P-129Intermediate frequency magnetic field and chick embryotoxicity
۵Izumi Nishimura, Tadashi Negishi (Environ Sci Res Lab, CRIEPI.)

P-130

Analysis of the inter- and intra-individual cervical-vaginal fluid (CVF)
components
۵Mami Kawaguchi1, Kuniaki Takagi1,2, Yasuko Ishikura1, Masashi Sekimoto1,
Kiyomitsu Nemoto1,
Masakuni Degawa1,
Kouichi Yoshinari1 (1Sch.
Pharmaceut. Sci., Univ of Shizuoka., 2Dept. Medical Technology. Sci., Azabu
Univ.)

P-131

Analysis of health injury cases caused by use of household spray۵ Tsuyoshi Kawakami, Kazuo Isama, Yoshiaki Ikarashi (Division ofEnvironmental Chemistry, National Institute of Health Sciences)

P-132

Evaluation of sensitization potential of plasticizers and antioxidants used inpolyvinyl chloride products
۵Yoshiaki Ikarashi, Tomoko Obama, Tsuyoshi Kawakami, Kazuo Isama(Division of Environmental Chemistry, National Institute of Health Sciences)

P-133

Bacterial monitoring in the International Space Station-“Kibo”
۵Tomoaki Ichijo1, Nobuyasu Yamaguchi1, Takashi Baba1, 2, Masao Nasu1(1Grad. Sch. Pharm. Sci., Osaka Univ., 2Fac. Agr., Tottori Univ.)

From Korea

P-134

Prothrombotic risk associated with intravenously given high dose vitamin C:
Another evidence warning against the blind faith in vitamins?
۵Keunyoung Kim1, Ok-Nam Bae2, Sung-Hee Koh1, Bian Yiying1, andJin-Ho Chung1 (1Coll. Pharm., Seoul National Univ., 2Coll. Pharm., Hanyang
Univ., Korea)

P-135

Procoagulant and prothrombotic effects of the herbal medicine, Dipsacus asperand its active ingredient, dipsacus saponin C, on human platelets
۵Ji-Sun Song, Keunyoung Kim, Yeryeon Jung, and Jin-Ho Chung (Coll.
Pharm., Seoul National Univ., Korea)

P-136

Alteration of oral toxicokinetic profiles of melamine by combined treatment ofrats with cyanuric acid
۵Tae Cheon Jeong, Mi Jeong Kang, Keunhan Noh, Wonku Kang1,
Hyung Sik Kim2ム1College of Pharmacy, Yeungnam University, Korea, Collegeof Pharmacy, Chung-Ang University, Korea, 2College of Pharmacy,
Sungkyunkwan University, Korea㸧

−80−

P-137

Metformin increases microrna-34a to down-regulate sirt1 expression leading toenhanced sensitivity of wild-type p53 cancer cells to oxidative stress۵Minh Truong Do, Hyung Gyun Kim, Hye Gwang Jeong 㸦Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸧

P-138

Metallothion-iii increases adam10 activity on non-amyloidogenic processing inneuronal cells
۵Bong Hwan Park, Hyung Gyun Kim, Hye Gwang Jeong㸦Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸧

P-139

Inhibitory effcts of saponins from the roots of platycodon grandiflorum on
ovalbumin-induced mice۵Jae Ho Choi1, Hyung Gyun Kim1, Young Chul Chung2, Hye Gwang Jeong1
㸦 1Department of Toxicology, College of Pharmacy, Chungnam National
University, Korea㸪2Department of Food and Medicine, College of Public Healthand Natural Science, International University of Korea, Korea㸧

P-140

Saponins from the roots of platycodon grandiflorum attenuates high fat
diet-induced non-alcoholic steatohepatitis in rats by inducing nrf2-mediatedantioxidant enzymes
۵Se Jong Kim1, Young Chul Chung2, Hye Gwang Jeong1㸦1Department of
Toxicology, College of Pharmacy, Chungnam National University, Korea㸪
2Department of Food and Medicine, College of Public Health and Natural
Science, International University of Korea, Korea㸧

P-141

Effect of betulinic acid on nitric oxide synthase phosphorylation and nitric oxide
production in endothelial cells
۵Sun Woo Jin, Hye Gwang Jeong㸦Department of Toxicology, College of
Pharmacy, Chungnam National University, Korea㸧

P-142

Saponins from the roots of platycodon grandiflorum, especially platycodin d,
attenuates atopic dermatitis-like skin symptoms dncb-induced mice andtnf-ǂ/ifn-Ǆ-exposed cells
۵Jae Ho Choi1, Young Chul Chung2, Hyun-Sun Lee3, Hye Gwang Jeong1
㸦 1Department of Toxicology, College of Pharmacy, Chungnam National
University, Korea㸪2Department of Food and Medicine, College of Public Healthand Natural Science, International University of Korea, Korea㸪3Molecular
Cancer Research Center, Korea Research Institute of Bioscience andBiotechnology, Korea㸧

−81−P-143

Anticancer effect of Hyrtios sp. extract in human colon carcinoma cells withdifferent p53 status
۵Joohee Jung1, Woori Bae1, Hyun Kyung Lim1, Ki Hwa Jung1, Youngmi Kim1,
Hyi-Seung Lee2㸦1College of Pharmacy, Duksung Women’s University, Korea㸪
2Korea Institute of Ocean Science & Technology, Korea㸧

P-144

Aroma therapy with essential oils in menopausal women or dementia patientschanges plama levels of cortisol and 5-ht
۵Young-Sook Kang 㸦Research Center for Cell Fate Control, College of
Pharmacy, Sookmyung Women’s University, Korea㸧

P-145

Acacetin sensitize HepG2 cells to TRAIL through DR5 up-regulation
۵Su Jung Han and An Keun Kim㸦College of Pharmacy, Sookmyung Women’s
University, Korea㸧

P-146

Selenium-binding protein 1 is a sensitive urinary biomarker for detection ofnephrotoxicity
۵Kyeong Seok Kim, Ji Yeon Son, and Hyung Sik Kim㸦Division of Toxicology,
School of Pharmacy, Sungkyunkwan University, Korea㸧

P-147

Metabolomics profiling against cadmium-induced nephrotoxicity in the urine ofSprague-Dawley rats
۵Yoon Jong Kang, Ji Yeon Son, and Hyung Sik Kim㸦Division of Toxicology,
School of Pharmacy, Sungkyunkwan University, Korea㸧

P-148

Uric acid induces endothelial dysfunction by vascular insulin resistanceassociated with the impairment of nitric oxide synthesis
۵ You-Jin Choi, Byung-Hoon Lee (College of Pharmacy, Seoul National
University, Korea)

P-149

Maternal exposure to simazine impairs the development of female mouseoffspring۵Seeun Park1, Sarang Kim1, Hong Jin1, Daeyoung Kim2, Kangseok Lee2 andJeehyeon Bae1㸦1School of Pharmacy, 2Department of Life Science, Chung-Ang
University, Korea㸧

P-150

A study for safety management of bisphenol A۵Mihi Yang and Myoung-Yun Pyo㸦Research Center for Cell Fate Control,
College of Pharmacy, Sookmyung Women’s University, Korea㸧

−82−

P-151A molecular epidemiological study to clarify tobacco smoking-specific toxic
mechanisms
۵Mihi Yang㸦Research Center for Cell Fate Control, College of Pharmacy,
Sookmyung Women’s University, Korea㸧

P-152

Polyhexamethylene guanidine phosphate induced inflammatory responses via
ROS-Nf-ǋB signaling pathway
۵Ha Ryong Kim, Da Young Shin, Min Sun Yi, Wun Hak Choo, Jeong Eun Lee,
Han Soo Cho, Kyu Hyuck Chung㸦School of Pharmacy, Sungkyunkwan
University, Korea㸧

−83−

Banquet
September 19（Fri）
   18：30 ～ 20：30
   Site: OKURA FRONTIER HOTEL TSUKUBA (MAIN BUILDING)
           Scientific Award Ceremony           Kanehara Award Ceremony           Presentation of Young Investigator Award Winners
and Conferment Ceremony           Presentation of Chief Organizer Award Winners
and Conferment Ceremony           Presentation of Rookie of the Year Award Winners
and Conferment Ceremony−84−