SAFETY DATA SHEET
Revision Date 06-Dec-2023

Revision Number 4
NGHS / English__________________________________________________________________________________________________________________________________________________________________________________________

1. IDENTIFICATION
Product identifier
Product NamemRNA Product in Aqueous Solution

Other means of identification
Product Code(s)CAS11195, CAS11196, CAS11859, CAS11860, CASXXXXX, PNPXXXXX, HDBIOPR12365, KIT-TNT-XX-XX

Synonyms
Recommended use of the chemical and restrictions on use
Recommended Use

For research use only

Restrictions on use

No information available

Details of the supplier of the safety data sheet
Supplier Identification

Dharmacon, Inc.,
Revvity, Inc.

Address

2650 Crescent Drive Suite 100,
Lafayette, CO 80026

TelephoneTel: 303-604-9499
Fax: 303-604-9680

E-mailTechnical@horizondiscovery.com

Emergency telephone number
Company Emergency Phone
NumberChemtrec International: 1-703-741-5970

2. HAZARDS IDENTIFICATIONClassification

The product contains no substances which at their given concentration, are considered to be hazardous to healthAppearance No information available

Physical state Solid Pellets

Odor No information available

GHS Label elements, including precautionary statements____________________________________________________________________________________________

Page 1 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________

Hazard statements
Other information

3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance

Synonyms

Ribonucleic acid oligonucleotide

Chemical name

CAS-NoWeight-%RNA
Aqueous Solution

63231-63-0-

1
99

Hazardous Material
Date HMIRA filed andInformation Review Act date exemption granted
registry number (HMIRA(if applicable)
registry #)-4. FIRST AID MEASURESFirst aid measures
Inhalation

Remove to fresh air. (Call a physician if symptoms occur).

Eye contact

Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids.
Consult a physician.

Skin contact

Wash off immediately with plenty of water. Get medical attention if symptoms occur.

Ingestion

DO NOT induce vomiting. Get medical attention if symptoms occur.

Most important symptoms and effects, both acute and delayed
Symptoms

No information available.

Indication of any immediate medical attention and special treatment needed
Note to physicians

Treat symptomatically.

5. FIRE-FIGHTING MEASURES
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and thesurrounding environment.

Large FireCAUTION: Use of water spray when fighting fire may be inefficient.

Unsuitable extinguishing media

Do not scatter spilled material with high pressure water streams.

Specific hazards arising from thechemical

No information available.

_____________________________________________________________________________________________

Page 2 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________
Explosion Data
Sensitivity to Mechanical Impact None.
Sensitivity to Static Discharge None.
Special protective equipment for
fire-fighters

Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.

6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Personal precautions

Ensure adequate ventilation. Use personal protective equipment as required. Avoidgeneration of dust.

Methods and material for containment and cleaning up
Methods for containment

Prevent further leakage or spillage if safe to do so.

Methods for cleaning up

Vacuum or sweep material and place in a disposal container. Avoid generation of dust.

7. HANDLING AND STORAGE
Precautions for safe handling
Advice on safe handling

Ensure adequate ventilation. Use personal protection equipment. Avoid generation of dust.

Conditions for safe storage, including any incompatibilities
Storage Conditions

Keep tightly closed in a dry place. Keep at -80°C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Exposure Limits

This product, as supplied, does not contain any hazardous materials with occupational
exposure limits established by the region specific regulatory bodies.

Appropriate engineering controls
Engineering controls

Showers
Eyewash stations
Ventilation systems.

Individual protection measures, such as personal protective equipment
Eye/face protection

Wear safety glasses with side shields (or goggles).

Skin and body protection

Wear suitable protective clothing.

_____________________________________________________________________________________________

Page 3 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________
Respiratory protection

No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.

General hygiene considerations

Handle in accordance with good industrial hygiene and safety practice.

9. PHYSICAL AND CHEMICAL PROPERTIES
Physical and Chemical Properties
Physical stateAppearance
Odor
Color
Odor Threshold

LiquidNo information available
No information available
No information available
No information available

PropertyValues
pH
No data available
Melting / freezing point
No data available
Boiling point / boiling range
No data available
Flash Point
No data available
Evaporation Rate
No data available
Flammability (solid, gas)
No data available
Flammability Limit in AirUpper flammability limit
No data available
Lower flammability limit
No data available
Vapor pressure
No data available
Vapor density
No data available
Relative density
No data available
Water Solubility
No data available
Solubility(ies)
No data available
Partition coefficient: n-octanol/water No data available
Autoignition temperature
No data available
Decomposition temperature
No data available
Kinematic viscosity
No data available
Dynamic viscosity
No data available
Other Information
Explosive properties
Oxidizing properties
Softening Point
Molecular Weight
VOC Content (%)
Liquid Density
Bulk Density
Particle Size
Particle Size Distribution

Remarks Method
None known
None known
None known
None known
None known
None known
None known

None known
None known
None known
None known
None known
None known
None known
None known
None known
None known

No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available

10. STABILITY AND REACTIVITY
Reactivity

No information available.

Chemical stability

Stable under normal conditions.

Possibility of Hazardous Reactions None under normal processing.
Conditions to avoid

Incompatible materials. Excessive heat. Exposure to air or moisture over prolonged
periods.

_____________________________________________________________________________________________

Page 4 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________
Incompatible materials

Alcohols.

Hazardous Decomposition Products Thermal decomposition can lead to release of irritating gases and vapors.

11. TOXICOLOGICAL INFORMATION
Information on likely routes of exposure
Product Information
Inhalation

Specific test data for the substance or mixture is not available.

Eye contact

Specific test data for the substance or mixture is not available.

Skin contact

Specific test data for the substance or mixture is not available.

Ingestion

Specific test data for the substance or mixture is not available.

Information on toxicological effects
Symptoms

No information available.

Numerical measures of toxicity
Acute ToxicityUnknown acute toxicity

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation

No information available.

Serious eye damage/eye irritation

No information available.

Respiratory or skin sensitization

No information available.

Germ cell mutagenicity

No information available.

Carcinogenicity

No information available.

Reproductive toxicity

No information available.

STOT - single exposure

No information available.

STOT - repeated exposure

No information available.

Aspiration hazard

No information available.

12. ECOLOGICAL INFORMATION_____________________________________________________________________________________________

Page 5 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________
Ecotoxicity

The environmental impact of this product has not been fully investigated.

Persistence and Degradability

No information available.

Bioaccumulation

There is no data for this product.

Mobility

No information available.

Other adverse effects

No information available.

13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Waste from residues/unused
products

Dispose of in accordance with local regulations. Dispose of waste in accordance withenvironmental legislation.

Contaminated packaging

Do not reuse empty containers.

14. TRANSPORT INFORMATION
DOT
UN-No.
Proper Shipping Name
Hazard Class
Subsidiary classNot regulated
UN1845
Carbon Dioxide, Solid
9III

TDG
UN Number
Proper Shipping NameHazard Class
Subsidiary classNot regulated
UN1845
Carbon Dioxide, Solid9III

MEXNot regulated

ICAO

Not regulated

IATA
UN Number
Proper Shipping Name
Hazard Class
Subsidiary classNot regulated
UN1845
Carbon Dioxide, Solid9
III

IMDG
UN Number
Proper Shipping Name
Hazard Class
Packing group

Not regulated
UN1845
Carbon Dioxide, Solid
9III

RID

Not regulated_____________________________________________________________________________________________

Page 6 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________ADR

Not regulated

ADN

Not regulated

15. REGULATORY INFORMATION
Safety, health and environmental regulations/legislation specific for the substance or mixtureInternational Regulations
Ozone-depleting substances (ODS) Not applicable
Persistent Organic Pollutants Not applicable
Export Notification requirements Not applicable
International Inventories
TSCA
DSL/NDSL
EINECS/ELINCS
ENCS
KECL
PICCS
AICS

Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.

LegendTSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances

US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any
chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372

SARA 311/312 Hazard Categories
Should this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriateclassifications. Under the amended regulations at 40 CFR 370, EPCRA 311/312 Tier II reporting for the 2017 calendar year willneed to be consistent with updated hazard classifications.
CWA (Clean Water Act)
This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42)

CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive
Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level
pertaining to releases of this material_____________________________________________________________________________________________

Page 7 / 8

mRNA Product in Aqueous Solution
Revision Date 22-Mar-2023_____________________________________________________________________________________________US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
This product does not contain any substances above threshold limits that are regulated by state right-to-know.

16. OTHER INFORMATION
NFPA

Health hazards 0

Flammability 0

Instability 0

HMIS

Health hazards 0

Flammability 0

Physical hazards 0

Prepared By

Dharmacon, Inc.,
Revvity, Inc.
2650 Crescent Drive Suite 100,
Lafayette, CO 80026

Revision Date

06-Dec-2023

Revision Note

No information available

Physical and Chemical
Properties Personal Protection X

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its
publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation,
disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specificmaterial designated and may not be valid for such material used in combination with any other materials or in any process, unlessspecified in the text

End of Safety Data Sheet_____________________________________________________________________________________________

Page 8 / 8