Plenary Lecture I
September 4 (Fri) 14:00 - 15:00 Track 1
Chair: Yoshito Kumagai (Fac. Med., Univ. Tsukuba)
Paper only

PL-1

Identification of target proteins and intracellular signaling for environmental
chemicals  ◯ Takashi Uehara(Grad. Sch. Med. Den. and Pharm. Sci., Okayama Univ.)

Plenary Lecture II
September 5 (Sat) 11:30 - 12:30 Track 1
Chair: Masahiko Satoh (Sch. Pharm., Aichi Gakuin Univ.)
PL-2

Selenium and Arsenic; their roles as toxicants, medicines, and nutrients◯ Seiichiro Himeno1, 2(1Sch. Pharm., Showa Univ., 2Fac. Pharm. Sci., Tokushima Bunri Univ.)

Educational Lecture
September 4 (Fri) 12:00 - 13:00 Track 1
Chair: Toshiyuki Kaji (Fac. Pharm. Sci., Tokyo Univ. Sci.)
Paper only

EL-1

Food hygiene and safety ---Assurance of food safety and quality control---  
◯ Hiroyasu Yamazaki(retired prof. Fac. Pharm. Sci., Kobe Gakuin Univ.)

Award Lecture
Scientific Award
September 5 (Sat) 13:30 - 14:00 Track 1
Chair: Shuntaro Hara (Sch. Pharm., Showa Univ.)
AL-1

Stress-responsive signaling triggered by internal and external environments andits molecular regulatory mechanisms◯ Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)−34−Kanehara Award
September 5 (Sat) 14:00 - 14:20 Track 1
Chair: Gi-Wook Hwang (Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)
AL-2

Mechanisms of methylmercury induced neurotoxicity via inductions ofinflammatory cytokines in microglia◯ Takashi Toyama(Grad. Sch. Pharm. Sci., Tohoku Univ.)

Forum I：Forefront of Lipid Research in Pharmaceutical Health
Science
September 4 (Fri) 9:30 - 11:30 Track 1
Organizer / Chair: Takeshi Kumagai (Sch. Pharm., Kitasato Univ.)
Hiroshi Kuwata (Sch. Pharm., Showa Univ.)
F1-1

In vivo roles of highly unsaturated fatty acid-preferring long-chain acyl-CoA
synthetase, ACSL4◯ Hiroshi Kuwata, Shuntaro Hara
(Sch. Pharm., Showa Univ.)

F1-2

The investigation of the role of prostaglandin F2α in sepsis◯ Toko Maehara, Ko Fujimori(Osaka Univ. Pharm. Sci.)

F1-3

Imaging MS analysis of phospholipids and lipid mediators using AP-MALDI-MS◯ Kuniyuki Kano1,2,3, Taiga Iwama2, Junken Aoki1,2,3(1Grad. Sch. Pharm. Sci., Univ. Tokyo., 2 Grad. Sch. Pharm. Sci., Tohoku Univ.,
3
AMED-LEAP)

F1-4

Identification of phosphorylation sites and the responsible protein kinases of
intracellular phospholipase A1◯ Naoki Matsumoto, Atsushi Yamashita(Fac. Pharm. Sci., Teikyo Univ.)

F1-5

Analysis of lipoxytosis suppression mechanism in SMS2 overexpressing cells◯ Takeshi Kumagai1,2, Hirotaka Imai1,2(1Sch. Pharm., Kitasato Univ., 2AMED-CREST)−35−

Forum II：Regulation of Biological Responses by Novel Reactive
Oxygen Species Signaling
September 4 (Fri) 15:30 - 17:30 Track 1
Organizer / Chair: Yoshito Kumagai (Fac. Med., Univ. Tsukuba)
Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
F2-1

A polycyclic aromatic hydrocarbon with redox cycle capability: Mechanisms
involved in generation of a variety reactive oxygen species and crosstalk in thecellular signaling pathways◯ Yoshito Kumagai(Fac. Med., Univ. Tsukuba)

F2-2

Regulatory mechanisms of the novel cell death parthanatos induced by reactive
oxygen species (ROS) signaling◯ Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

F2-3

Development of fluorescent probes for H2S and sulfane sulfur and their application
to the inhibitor screening◯ Kenjiro Hanaoka(Grad. Sch. Pharm. Sci., The Univ. Tokyo)

F2-4

Novel mechanism of suppression of lipid peroxidation in heart through theintestine by antibiotics◯ Hirotaka Imai, Tomoko Koumura(Sch. Pharm. Sci, Kitasato Univ.)

Forum III：Methods of Analysis in Health Science 2020 :Validation of Test Method
September 5 (Sat) 9:00 - 11:00 Track 1
Organizer / Chair: Hiroshi Akiyama (National Institute of Health Sciences)
Yasuyuki Fujiwara (Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)
F3-1

Validation of analytical methods◯ Rieko Matsuda(National Institute of Health Sciences)

F3-2

Validation of analytical methods for testing agricultural chemical residues in food
◯ Satoru Nemoto(National Institute of Health Sciences)−36−

Paper only

F3-3

Validation of the Drinking Water Quality Test Method◯ Norihiro Kobayashi(National Institute of Health Sciences)

F3-4

Validation of microbiological testing methods in regional Institute of Health◯ Ryohei Nomoto(Kobe Institute of Health)

Forum IV：Up-to-date Research on Pharmaco-Metal Bioscience
September 5 (Sat) 14:50 - 16:50 Track 1
Organizer / Chair: Yasumitsu Ogra (Grad. Sch. Pharm. Sci., Chiba Univ.)
Hitomi Fujishiro (Fac. Pharm. Sci., Tokushima Bunri Univ.)
F4-1

Elucidation of the novel transport mechanism of selenium via selenoprotein P◯ Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

F4-2

Copper accumulation in the brain of a Down syndrome mouse model and its
pathophysiological significance◯ Keiichi Ishihara(Kyoto Pharm. Univ.)

F4-3

Dysfunction of manganese metabolism due to mutations of zinc transporter ZIP8
◯ Hitomi Fujishiro1, Seiichiro Himeno1,2(1Fac. Pharm. Sci., Tokushima Bunri Univ., 2Sch. Pharm., Showa Univ.)

F4-4Development of single cell trapping and handling tool for biometal sciences◯ Tomonari Umemura1, Motohide Aoki1, Yanbei Zhu2, Akitoshi Okino3, Takao Yasui2(1Sch. Life Sci., Tokyo Univ. Pharm. and Life Sci., 2NMIJ, AIST, 3FIRST, Tokyo Tech.,
4
Grad. Sch. Eng., Nagoya Univ.)−37−

Award Candidates Presentation
Candidates for Young Investigator Award
September 4 (Fri) 9:30 - 10:33 Track 2
Chair: Chika Yamamoto (Fac. Pharm. Sci., Toho Univ.)
P-036

Increased disruption of redox homeostasis and concomitant protein modification
caused by combined exposure to metals with electrophilic property◯ Hiroto Yamakawa1, Masahiro Akiyama1,2, Yoshito Kumagai1,2(1Grad. Sch. Med Sci., Tsukuba Univ., 2Fac. Medicine., Tsukuba Univ.)

P-046

Roles of the E3 ubiquitin ligase LINCR as a novel therapeutic target for fulminant
inflammatory diseases◯ Takumi Yokosawa, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-048

Analysis of effects of a mutation in C-terminal region of HCV Core protein on
endoplasmic reticulum (ER)-membrane protein and ER stress response◯ Ryoya Sekine, Shusuke Kuge
(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)

P-049

PPARγ-driven adipogenesis is involved in thymic atrophy induced by triphenyltin,
but not tributyltin.
◯ Erina Shiraishi1, Kyohei Takano1, Daisuke Matsumaru1, Akiko Ido1,
Hisamitsu Nagase1, 2, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Univ. Med Sci.)

P-051

Arginyltransferase 1 is a key regulator of human immunodeficiency virus type 1
uncoating.
◯ Ryosuke Okano1, Naoki Kishimoto1, Nobutoki Takamune2, Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ., 2KIDO)

P-054

Elucidation of the novel mechanisms by which gefitinib initiates inflammatory side
effects◯ Tomohiro Kagi, Rio Naganuma, Yuto Sekiguchi, Yusuke Hirata, Takuya Noguchi,
Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)−38−

P-056

Intracellular behavior of lysosomal hydrolases in lysosomal membrane
permeabilization◯ Ayaka Yabuki1, Masatsugu Miyara1,2,3, Kanae Umeda1, Natsumi Okada1,
Namiko Watanabe1, Yaichiro Kotake1(1Grad. Sch. Biomed. and Health Sci., Hiroshima Univ., 2Gifu Pharm. Univ., 3JSPS
Research Fellow PD)

P-076

An unexpected system for adaptive defense against electrophilic stress in out of cell
◯ Yusuke Onose1, Masahiro Akiyama1,2, Yoshito Kumagai1,2(1Grad. Sch. Med Sci., Tsukuba Univ., 2Fac. Med., Tsukuba Univ.)

P-091

Assessment of mechanism underlying diphenhydramine-induced cardiotoxicity incardiomyocytes◯ Erika Morita1, Seigo Sanoh1,2, Chizuru Imako2, Chieri Fujino1, Yuya Ohtsuki1,
Masatsugu Miyara1,3,4, Katsuhiro Okuda5, Shigeru Ohta1,2,6, Yaichiro Kotake1,2(1Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Pharm. Sci., Hiroshima Univ.,
3
Gifu Pharm. Univ., 4JSPS Research Fellow PD, 5Asahikawa Med. Univ., 6WakayamaMed. Univ.)−39−

Award Candidates Presentation
Candidates for Rookie of the Year Award
September 4 (Fri) 10:33 - 11:22 Track 2
Chair: Tomoki Kimura (Fac. Sci. and Eng., Setsunan Univ.)
P-007

Nigral AMPA receptor activation plays a key role for age-related Parkinson's
syndrome◯ Nana Saeki1, Ryusuke Nishio2, Misa Katahira1, Satoko Nakajima2, Hiroki Morioka2,
Azusa Takeuchi1, Haruna Tamano1,2, Atsushi Takeda1,2(1Sch. Pharm. Sci., Univ. Shizuoka, 2Grad. Sch. Pharm. Sci., Univ. Shizuoka)

P-011

Establishment of a novel toxicity test for anti-androgenic chemicals using androgen
overproducing transgenic mice.
◯ Takahiro Hirano1, Daisuke Matsumaru1, Keisuke Ito1, Kyoko Mekada1,
Yasushi Nishioka1, Hisamitsu Nagase1,2, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Univ. Med. Sci.)

P-012

Toxicological assessment of trans -fatty acids using novel molecular bases◯ Ryo Ashida, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-018

Disruption of selenohomeostasis by Se-mercuration of selenoprotein P◯ Runa Kudo, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-019

LAT-1 and MRP-2 as transporters involved in sensory nerve-specific toxicity of
methylmercury◯ Kazuhiro Aoki1, Eiko Yoshida1, Yo Shinoda2, Yasuyuki Fujiwara2, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)

P-020

Involvement of TNF-α in the neurotoxicity of methylmercury◯ Fumika Katami1, Eiko Yoshida1, Yo Shinoda2, Yasuyuki Fujiwara2, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)

P-039

Oral exposure of titanium oxide (IV) nanoparticles promotes liver steatosis◯ Ryo Koike1, Daisuke Matsumaru1, Iori Tsubakihara1, Hisamitsu Nagase1,2,
Yasuo Yoshioka3, Yu-ki Tanaka4, Yasumitsu Ogura4, Tsuyoshi Nakanishi1(1Gifu Pharm.Univ., 2Gifu Univ. Med. Sci., 3Res. Inst. for Microbial Diseases, Osaka
Univ.,4Grad. Sch. Pharm. Sci., Chiba Univ.)−40−

Oral Session 1
Metals
September 4 (Fri) 15:10 - 15:55 Track 2
Chair: Tomofumi Okuno (Fac. Pharm. Sci., Setsunan Univ.)
O1-1

Loss of metalloestrogenic effects of cadmium on long-term estrogen-deprived
MCF-7 cells (LTED cells): Involvements of ligand-independently activated ERα◯ Masayo Hirao-Suzuki1, Shuso Takeda1,2, Narumi Sugihara2, Masufumi Takiguchi1(1Fac. Pharm. Sci., Hiroshima Intl. Univ., 2 Fac. Pharm. Sci., Fukuyama Univ.)

O1-2

Identification of protein reactive with reduced metabolite of selenious acid in rat
brain◯ Sakura Yoshida1, Akinori Yamamoto1, Hiroshi Masumoto2, Eriko Hori1, Sakiko Ura1,
Takeshi Fuchigami1, Mamoru Haratake3, Morio Nakayama1(1Grad. Sch. Biomed. Sci., Nagasaki Univ., 2BRSC, Sch. Med., Nagasaki Univ., 3Fac.
Pharm. Sci., Sojo Univ.)

O1-3

Ablation of selenium binding protein 1 (Selenbp1) alters lipid metabolism andoxidative stress.
◯ Yingxia Song1, Atsushi Kurose1, Ren-shi Li1, Tomoki Takeda1, Yuko Onomura1,
Takayuki Koga2, Takumi Ishida3, Yoshitaka Tanaka1, Yuji Ishii1(1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Daiichi Univ. Pharm., 3Sch. Pharm. Fukuoka,
Intl. Univ. Health and Welfare)

Oral Session 2
Foods・Analysis
September 4 (Fri) 16:00 - 17:00 Track 2
Chair: Yoshinori Okamoto (Fac. Pharm., Meijo Univ.)
O2-1

Pancreatic morphological deficiencies caused by fetal growth restriction and theirexacerbation of male offspring induced by rich nutrition◯ Atsuto Onoda1,2, Mahboba Jabary, Yuma Kitase2,3, Masahiro Hayakawa2,
Yoshiaki Sato2.
(1Dep. Pharma., Sanyo-Onoda city Univ., 2Cent. Mat-Neonate., Nagoya Univ. Hosp.,
3
Johns Hopkins Univ.)

O2-2

Surveys of natural radionuclide, polonium-210 in foods◯ Keisuke Soga, Kazunari Kondo, Akiko Hachisuka(National Institute of Health Sciences)

−41−

O2-3

Determination of phthalates with gas chromatography/mass spectrometry (GC/MS): Additional method for 16000-33◯ Shinobu Sakai1, Shin-ichi Tanabe2, Hyuntae Kim3, Kazuhide Ito4, Maiko Tahara1,
Ikue Saito5, Toshiko Tanaka-Kagawa6, Hideto Jinno7, Yoshiaki Ikarashi1(1NIHS, 2Waseda Univ., 3Yamaguchi Univ., 4Kyushu Univ., 5Tokyo Metropolitan
Institute of Public Health, 6Yokohama Univ. Pharm., 7Fac. Pharm., Meijo Univ.)

O2-4

Stereoscopic analyses for cloacal development: abnormal endodermal β-cateninsignaling causes anorectal malformation◯ Daisuke Matsumaru1,2, Aki Murashima3, Shinichi Miyagawa4, Masayo Harada5,
Gen Yamada2, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Wakayama Med. Univ., 3Iwate Med. Univ., 4Tokyo Univ. Sci.,
5
Tokyo Med. and Dent. Univ.)

Oral Session 3
Biochemistry
September 5 (Sat) 9:00 - 9:45 Track 2
Chair: Masashi Sekimoto (Grad. Sch. Environ. Health, Azabu Univ.)
O3-1

Suppressive role of a guanine nucleotide exchange factor FGD1 in cadherinmediated cell-cell adhesion◯ Toshiyuki Oshima, Eri Ichikawa, Shunsuke Fujirawa, Tomofumi Fujino,
Makio Hayakawa(Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)

O3-2

Role of prostacyclin synthase in cyclophosphamide-induced hemorrhagic cystitis◯ Tsubasa Ochiai1, Nanako Yoshida1, Mei Maeda1, Yuka Sasaki1, Chieko Yokoyama2,
Shuntaro Hara1(1Sch. Pharm., Showa Univ., 2Kanagawa Inst. Tech.)O3-3Mice lacking Ah receptor in the adipose tissue are resistant to high fat diet-induced
adipose tissue inflammation and diabetes.
◯ Taira Wada, Yuki Kasakura, Jun Matsubara, Ayaka Yamada, Hirotake Ishii,
Yukiko Takasugi, Shigeki Shimba(Sch. Pharm., Nihon Univ.)−42−

Paper only

O3-4

Analysis of the pathogenic mechanism of non-alcoholic fatty liver disease caused
by depletion of lysoPI acyltransferase 1 (LPIAT1)◯ Yuki Tanaka1, Yuta Shimanaka1, Andrea Caddeo2, Hiroyuki Arai3, Stefano Romeo2,
Nozomu Kono1, Junken Aoki1(1 Grad. Sch. Pharm. Sci., Univ. Tokyo, 2 Dep. Molecular and Clinical Medicine, Univ.
Gothenburg, 3Grad. Sch. Med., Univ. Tokyo)

Oral Session 4
Biochemistry・Preventive Pharmacology
September 5 (Sat) 10:00 - 11:00 Track 2
Chair: Nozomu Kono (Grad. Sch. Pharm. Sci., Univ. Tokyo)
O4-1

Proteasomal degradation of human Rad17 protein is promoted by the N-terminal
destruction box and nuclear translocation◯ Yasunori Fukumoto1, Masayoshi Ikeuchi2, Liang Qu1, Tyuji Hoshino1,
Yuji Nakayama2, Yasumitsu Ogra1(1 Grad. Sch. Pharm. Sci., Chiba Univ., 2 Kyoto Pharm. Univ.)

O4-2

Charactarization of the retinoic acid receptor (RAR) Orthologue in priapulid
worm, Priapulus caudatus, an Ecdysozoa.
◯ Youhei Hiromori1,2, Elza Fonseca3, Yoshifumi Kaite1, Raquel Ruivo3,
João N. Franco3, Miguel M. Santos3, L. Filipe C. Castro3, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2College of Pharm, Suzuka Med. Sci. Univ., 3CIIMAR, Univ.
Porto)

O4-3

Statins attenuate antiviral innate immune responses through inhibiting IRF3mediated JAK/STAT signaling pathway in macrophages and hyperlipidemic mice
◯ Atsushi Koike, Ko Fujimori(Osaka Univ. Pharm. Sci.)

O4-4

Removal of extracellular vesicles from influenza virus infected eggs reduces thepyrogenic effect of vaccination and increases vaccine immunogenicity.
◯ Naoki Kishimoto1, Takuma Gotanda2, Toshimasa Takasaki1, Nobutoki Takamune3,
Ryotarou Mitsumata2, Shogo Misumi2(1Grad. Sch. Pharm. Sci., Kumamoto Univ., 2 Denka Co.,Ltd., 3KIDO)−43−

Oral Session 5
Cellular Responses
September 5 (Sat) 14:50 - 15:35 Track 2
Chair: Yo Shinoda (Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)

Paper only

O5-1

Induced expression of Mmp-3 , -12 , -13 in the photothrombosis model brain◯ Hiroshi Hasegawa1, Hirofumi Hohjoh1, Io Horikawa1, Kimie Nakagawa1,
Eri Segi-Nishida2(1Lab. Hygienic. Sci., Kobe Pharm. Univ., 2Dep. Biol. Sci., Fac. Ind. Sci. Tech., Tokyo
Univ. Sci.)

O5-2trans -Fatty acids facilitate DNA damage-induced apoptosis via the two distinct
mechanisms◯ Yuto Yamada, Aya Inoue, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

O5-3

A quantitative proteomics strategy to identify Lipoxytosis regulators Lipo-4
containing E3 ubiquitin ligase complex.
◯ Masaki Matsuoka1, Into Li 1, Yoshio Kodera2,Hirotaka Imai1(1Sch. Pharm., Kitasato Univ., 2Sch. Sci., Kitasato Univ.)

O5-4

Membrane lipid saturation causes EMC6 degradation and EMC dysfunction.
◯ Nozomu Kono1, Yukari Miyagawa1, Takehiro Suzuki2, Naoshi Dohmae2,
Hiroyuki Arai3, Junken Aoki1(1 Grad. Sch. Pharm. Sci., Univ. Tokyo, 2 Biomol. Charact. Unit., RIKEN CSRS, 3Grad.
Sch. Med., Univ. Tokyo)

Oral Session 6
Cellular Responses・Immunotoxicity・Oxidative Stress
September 5 (Sat) 15:50 - 16:50 Track 2
Chair: Noriyuki Suzuki (Grad. Sch. Pharm. Sci., Chiba Univ.)
O6-1

The effect of activated-aryl hydrocarbon receptor on human epidermal growth
factor receptor family gene expression in breast cancer cells.
◯ Naoya Yamashita1, 2, Yuichiro Kanno2, 3, Noriko Sanada1, Kiyomitsu Nemoto 2,
Ryoichi Kizu1(1 Fac. Pharm. Sci., Doshisha Womenʼs College of Liberal Arts., 2 Fac. Pharm. Sci.,
Toho Univ., 3 Sch. Pharm. Sci., Univ. Shizuoka)

−44−

O6-2

Comparative analyses of the molecular mechanisms regulating thymic involutions
induced by dietary restriction and glucocorticoid treatments◯ Nurhanani Razali，Hirofumi Hohjoh，Hiroshi Hasegawa（Lab. Hygienic Sci., Kobe Pharm. Univ.）

O6-3

Antiporters regulating redox homeostasis for inside and outside of cell
◯ Masahiro Akiyama1, Takamitsu Unoki2, Hanako Aoki3, Yoshito Kumagai1(1Fac. Med. Univ. Tsukuba., 2Basic Med Sci. MIND., 3 Grad. Sch. Med Sci., Tsukuba
Univ.)

O6-4

Phosphorylation of TAB1 by Src: A new signaling pathway of oxidative stress.
◯ Hiroyuki Iwahara1, Yusuke Iwata1, Kanako Natori1, Tatsuhiko Ozawa2, Yue Zhou1,
Kiyonao Sada3, Satoru Yokoyama1, Hiroaki Sakurai1(1Fac. Pharm. Sci., Univ. Toyama., 2Fac. Med., Univ. Toyama., 3Fac. Med., Fukui Univ.)−45−

e-Poster (Poster Session)
Environmental Pollutants
Paper only

P-001

Analysis of phosphorus flame retardants in different kinds of house dust
◯ Kanae Bekki1, Atsuko Araki2, Yu Ait bamai2, Kenichi Azuma3, Reiko Kishi2(1National Institute of Public Health, 2 Fac. Pharm. Sci., Hokkaido Univ., 3Fac. Pharm.,
Kindai Univ.)

Paper only

P-002

Removal of dyes and metal in textile wastewater by 21 kinds of waste tea leaves.
◯ Takehiro Nakamura, Sayuri Mishima, Tsukine Fujimoto, Fumihiko Ogata,
Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-003

Autophagy receptor p62 plays a protective role in methylmercury-mediatedendoplasmic reticulum stress, autophagy, and proteasomal degradation◯ Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguch,
Masako, Kiyono(Sch. Pharm., Kitasato Univ.)

Paper only

P-004

Involvement of oncostatin M in the TNF receptor 3-mediated methylmercuryinduced neuronal cell death in mouse brain◯ Yohei Tsunoda1,2, Takayuki Hoshi1,2,3, Takashi Toyama1, Akira Naganuma1,
Yoshiro Saito1, Gi-Wook Hwang2(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.,
3
JSPS Research Fellow)

Paper only

P-005

Study on the hydrolyzability of 2-ethyl-1-hexanol esters
Yoko Mori1, Akira Aoki1, Yoshinori Okamoto1, Nobumitsu Hanioka2,
Toshiko Tanaka-Kagawa2, Maiko Tahara3, Tsuyoshi Kawakami3, Shinobu Sakai3,○ Hideto Jinno1(1Fac. Pharm., Meijo Univ., 2Yokohama Univ. Pharm., 3National Institute of Public
Health)P-006

Role of aryl hydrocarbon receptor (AHR) to the brain sexual differentiation.
Haruki Fukumitsu1, Tomoki Takeda1,2, Kyoko Nishida1, Yoshitaka Tanaka1,◯ Yuji Ishii1(1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Japan Bioassay Research Center)−46−

Neural Toxicity
P-007

Nigral AMPA receptor activation plays a key role for age-related Parkinson's
syndrome◯ Nana Saeki1, Ryusuke Nishio2, Misa Katahira1, Satoko Nakajima2, Hiroki Morioka2,
Azusa Takeuchi1, Haruna Tamano1,2, Atsushi Takeda1,2(1Sch. Pharm. Sci., Univ. Shizuoka, 2Grad. Sch. Pharm. Sci., Univ. Shizuoka)

P-008

The mechanism of acrylamide-induced neurite retraction in monoaminergic
neurons◯ Harue Sato1, Cai Zong1, Benoit Schneider2, Makoto Urushitani3, Gaku Ichihara1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Univ. Paris, Inserm UMR-S1124, 3Shiga Univ.
Med. Sci.)

Endocrine Disruptors

Paper only

P-009

Possible role of death associated protein-like 1 (Dapl1) in hypothalamus-pituitaryadrenal axis: study using Dapl1-knockout mice
◯ Hong-bin Chen1, Hiroe Sano1, Ren-shi Li1,2, Yukiko Hattori1, Tomoki Takeda1,3,
Yoshitaka Tanaka1, Yuji Ishii1(1Grad. Sch. Pharm. Sci., Kyushu Univ., 2China Pharm. Univ., 3Japan Bioassay ResearchCenter)P-010

Protective functions of complement component 8 γ in liver steatosis induced bytriphenyltin◯ Katsuya Yamamoto1, Daisuke Matsumaru1, Iori Tsubakihara1, Akira Aoki1,
Youhei Hiromori2, Hisamitsu Nagase3, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2 College of Pharm, Suzuka Med. Sci. Univ., 3Gifu Univ. Med.
Sci.)

P-011

Establishment of a novel toxicity test for anti-androgenic chemicals using androgen
overproducing transgenic mice.
◯ Takahiro Hirano1, Daisuke Matsumaru1, Keisuke Ito1, Kyoko Mekada1,
Yasushi Nishioka1, Hisamitsu Nagase1,2, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Univ. Med. Sci.)

Foods and Pesticides
P-012

Toxicological assessment of trans -fatty acids using novel molecular bases◯ Ryo Ashida, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)−47−

P-013

Activation of Nrf2 and diminished arsenic level by Coriandrum sativum L. leaves
hexane extract containing a variety of (E)-2-alkenals◯ Yumi Abiko1,2,3, Hanako Aoki2, Miyuki Okada3, Mai Mizokawa4, Yoshito Kumagai1,2,3(1Fac. Med., Univ. Tsukuba, 2Comp. Human Sci., Univ. Tsukuba, 3Med. Sci., Univ.
Tsukuba, 4Environ. Sci., Univ. Tsukuba)

P-014

Inhibitory effects on cell proliferation and cell death-inducing activities of
constituents from Hibiscus tiliaceus◯ Daisuke Imahori, Takahiro Matsumoto, Kaduki Achiwa, Youhei Saito,
Naoto Kojima, Masayuki Yamashita, Yuji Nakayama, Tetsushi Watanabe(Kyoto Pharm. Univ.)

Metals
P-015

Effects of repeated administration of gadolinium contrast agents on testis in mice
○ Ryosuke Nakamura, Yasukazu Takanezawa, Yuka Ohshiro, Shimpei Uraguchi,
Masako Kiyono(Sch. Pharm., Kitasato Univ.)

P-016

Transcription of mer operon and function of novel mer gene in Pseudomonas K-62
plasmid pMR68◯ Yuka Ohshiro, Chihiro Yamaoka, Shimpei Uraguchi, Ryosuke Nakamura,
Yasukazu Takanezawa, and Masako Kiyono(Sch. Pharm., Kitasato Univ.)

P-017

Vulnerability of S3-segment of proximal tubule on platinum-containing drugs◯ Hiroki Taguchi1, Hitomi Fujishiro1, Seiichiro Himeno2, Daigo Sumi1(1Fac. Pharm. Sci., Tokushima Bunri Univ., 2Sch. Pharm., Showa Univ.)

P-018

Disruption of selenohomeostasis by Se-mercuration of selenoprotein P◯ Runa Kudo, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-019

LAT-1 and MRP-2 as transporters involved in sensory nerve-specific toxicity of
methylmercury◯ Kazuhiro Aoki1, Eiko Yoshida1, Yo Shinoda2, Yasuyuki Fujiwara2, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)

P-020

Involvement of TNF-α in the neurotoxicity of methylmercury◯ Fumika Katami1, Eiko Yoshida1, Yo Shinoda2, Yasuyuki Fujiwara2, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Sch. Pharm., Tokyo Univ. Pharm. and Life Sci.)−48−

P-021

Induction of metallothionein isoforms by cadmium in vascular endothelial cells◯ Yusuke Ozaki1, Tomoya Fujie2, Fukuta Takenaka1, Chika Yamamoto2,
Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Fac. Pharm. Sci., Toho Univ.)

P-022

Application of laser ablation (LA)-ICP-MS for the screening of bacteria having
demethylation activity of methylmercury◯ Kazuaki Takahashi1,2, Yasunori Fukumoto1, Yasumitsu Ogra1(1Grad. Sch. Pharm. Sci., Chiba Univ., 2JSPS Research Fellow)

P-023

Development of caged selenocompounds for the elucidation of selenium
metabolism◯ Moka Hirayama, Chihiro Naito, Noriyuki Suzuki, Yu-ki Tanaka, Yasunori Fukumoto,
Yasumitsu Ogra
(Grad. Sch. Pharm. Sci., Chiba Univ.)

Paper only

P-024

Mechanism involved in methylmercury-induced TNF-α expression via p38 in
microglia, and its involvement in neuronal cell death◯ Takayuki Hoshi1,2,3, Takashi Toyama1, Akira Naganuma1, Yoshiro Saito1,
Gi-wook Hwang2(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.,
3
JSPS Research Fellow)

Paper only

P-025

The effect of molar ratio on adsorption of phosphate ion and pH on preparation ofmagnesium-iron-aluminum hydroxides.
◯ Riku Nagafuji, Takehiro Nakamura, Tomoki Fujiwara, Fumihiko Ogata,
Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

Paper only

P-026

Production of K-type zeolite for practical application and removal of lead ion◯ Yuhei Kobayashi, Fumihiko Ogata, Takehiro Nakamura, Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-027

Reduction of electrical conductivity using activated bentonites treated withdifferent acids◯ Eri Nagahashi, Fumihiko Ogata, Takehiro Nakamura, Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-028

Fear memory via long-term potentiation is regulated by Zn2+ in the amygdala◯ Yudai Ishikawa1, Ryusei Itoh2, Haruna Tamano1,2, Atsushi Takeda1,2(1Grad. Sch. Pharm. Sci., Univ. Shizuoka, 2Sch. Pharm. Sci., Univ. Shizuoka)−49−

Paper only

P-029

Effect of GGT inhibitor on cadmium-induced cytotoxicity in endothelial cells◯ Erina Kumano, Keisuke Sato, Ryosuke Tatsunami(Sch. Pharm., Hokkaido Univ. Sci.)

P-030

Nucleolin downregulation enhances cadmium cytotoxicity in vascular endothelialcells◯ Yasuyuki Fujiwara1, Tsutomu Takahashi1, Ai Yumoto1, Yuki Miyazaki1,
Masumi Kosaka1, Yayoi Tsuneoka1, Yo Shinoda1, Toshiyuki Kaji2(1Sch. Pharm. Tokyo Univ. Pharm. and Life Sci., 2Fac. Pharm. Sci., Tokyo Univ. Sci.)

P-031

Effect of sodium arsenite on procoagulant activity in cultured human immune
cells.
〇 Tsuyoshi Nakano1, Yumi Araki1, Tsutomu Takahashi1, Chika Yamamoto2,
Toshiyuki Kaji3, Yasuyuki Fujiwara1(1Sch. Pharm., Tokyo Univ. Pharm. and Life Sci., 2Fac. Pharm. Sci., Toho Univ., 3Fac.
Pharm. Sci., Tokyo Univ. Sci.,)

P-032

Potentiation of cadmium-induced cytotoxicity of endothelial cells by TGF-β1 andits mechanisms◯ Tomoya Fujie1, Masahiro Shimomura2, Toshiyuki Kaji2, Chika Yamamoto1(1Fac. Pharm. Sci., Toho Univ., 2Fac. Pharm. Sci., Tokyo Univ. Sci.)

P-033

The cytotoxicity of pentavalent organoantimony compounds is independent of
intracellular accumulation◯ Takato Hara1, Shihoko Nakano2, Yuki Kitamura3, Chika Yamamoto1, Shuji Yasuike3,
Toshiyuki Kaji2(1Fac. Pharm. Sci, Toho Univ., 2Fac. Pharm. Sci, Tokyo Univ. Sci., 3Sch. Pharm., Aichi
Gakuin Univ.)

P-034

Titanium dioxide nanoparticle-induced testicular dysfunction in mice
◯ Nobuhiko Miura 1, Hiroki Yoshioka 2, 3, Katsumi Ohtani 4(1 Yokohama Univ. Pharm., 2 Kinjo Gakuin Univ., 3 Univ. Texas Health Sci. Houston,
4
Natl. Inst. Occu. Safety Health)P-035

Molecular structure analysis of metallothionein-3 by Raman spectroscopy◯ Yasuhiro Shinkai1,2, Yunjie Ding2, Masahiro Akiyama1, Sumeet Mahajan3,
Yoshito Kumagai1,2(1Fac. Med., Univ. Tsukuba, 2Grad. Sch. Comprehensive Human Sci., Univ. Tsukuba,
3
Univ. Southampton)−50−

Paper only

Paper only

P-036

Increased disruption of redox homeostasis and concomitant protein modification
caused by combined exposure to metals with electrophilic property◯ Hiroto Yamakawa1, Masahiro Akiyama1,2, Yoshito Kumagai1,2(1Grad. Sch. Med Sci., Tsukuba Univ., 2Fac. Medicine., Tsukuba Univ.)

P-037

Re-analysis of public whole genome bisulfite sequencing data to reveal the effect of
cadmium on DNA methylation in metallothionein gene
Shoko Ogushi, ◯ Tomoki Kimura(Fac. Sci. Eng., Setsunan Univ.)

P-038

The effects of food additive grade titanium oxide (IV) on glycolipid metabolism◯ Yuki Takeshita1, Ryo Koike1, Daisuke Matsumaru1, Yasuo Yoshioka2, Yu-ki Tanaka3,
Yasumitsu Ogura3, Tsuyoshi Nakanishi1(1Gifu Pharm.Univ.,2Res. Inst. for Microbial Diseases, Osaka Univ.,3Grad. Sch. Pharm.
Sci., Chiba Univ.)

P-039

Oral exposure of titanium oxide (IV) nanoparticles promotes liver steatosis◯ Ryo Koike1, Daisuke Matsumaru1, Iori Tsubakihara1, Hisamitsu Nagase1,2,
Yasuo Yoshioka3, Yu-ki Tanaka4, Yasumitsu Ogura4, Tsuyoshi Nakanishi1(1Gifu Pharm.Univ., 2Gifu Univ. Med. Sci., 3Res. Inst. for Microbial Diseases, Osaka
Univ.,4Grad. Sch. Pharm. Sci., Chiba Univ.)

Oxidative Stress
Paper only

P-040

Reactive sulfur species inhibit PDGF-induced vascular smooth muscle cell
migration through regulation of focal adhesion formation◯ Shunichi Ishii, Hiroki Fujimori, Mayu Watanabe, Takashi Ashino,
Satoshi Numazawa(Sch. Pharm., Showa Univ.)

Paper only

P-041

Mechanism of metabolic adverse reactions by olanzapine and its relationship to
the sex difference◯ Natsumi Hattori1, 2, Asuka Kaizaki-Mitsumoto1, 2, Satoshi Numazawa1, 2(1Sch. Pharm., Showa Univ., 2 Pharmacol. Res. Center, Showa Univ.)

P-042

The various redox regulation of rate-limiting enzyme in glycolysis effects oxidative
stress response and anticancer drugs sensitivity◯ Hayato Irokawa, Shin Kato, Satoshi Numasaki, Shusuke Kuge
(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)

P-043

Role of a HSP70 co-chaperon BAG-1 on oxidative stress◯ Koki Takeda, Hayato Irokawa, Shusuke Kuge
(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)−51−

P-044Time-dependent change of physiological parameters and cell composition in
bronchoalveolar lavage fluid by continuous inhalation of high concentration
oxygen in mice
◯ Marie Sawa1, Akira Ushiyama2, Kenji Hattori1, Kazuyuki Ishii1(1 Meiji Pharm. Univ., 2National Institute of Public Health)P-045

A possible resistance mechanism of human malignant meningioma cells tophotodynamic therapy using talaporfin sodium◯ Tsutomu Takahashi1, Momoko Sakamoto1, Nanako Saeki1, Yo Shinoda1,
Jiro Akimoto2, Yasuyuki Fujiwara1(1Sch. Pharm. Tokyo Univ. Pharm. and Life Sci., 2Tokyo Med. Univ.)

Immunotoxicity・Infectious Diseases

Paper only

P-046

Roles of the E3 ubiquitin ligase LINCR as a novel therapeutic target for fulminant
inflammatory diseases◯ Takumi Yokosawa, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-047

The activation of murine mast cells by staphylococcal superantigen-like 12○ Kim Gwang Dong1,2, Ayaka Urabe1, Masato Kobayashi1, Takuma Kitano1,
Haruki Takito1, Ayana Ogata1, Hikaru Inoue1, Kazuhito Hayashi1, Susumu Ohya2,
Shigeaki Hida1, Saotomo Itoh1(1Grad. Sch. Pharm. Sci., Nagoya city Univ., 2Grad. Sch. Med. Sci., Nagoya city Univ.)

P-048

Analysis of effects of a mutation in C-terminal region of HCV Core protein on
endoplasmic reticulum (ER)-membrane protein and ER stress response◯ Ryoya Sekine, Shusuke Kuge
(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)

P-049

PPARγ-driven adipogenesis is involved in thymic atrophy induced by triphenyltin,
but not tributyltin.
◯ Erina Shiraishi1, Kyohei Takano1, Daisuke Matsumaru1, Akiko Ido1,
Hisamitsu Nagase1, 2, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Univ. Med. Sci.)

P-050

Effect of oxidized olive oil on cutaneous sensization of contact dermatitis◯ Hirofumi Ogino, Masaya Funakoshi, Ryoma Yamazaki, Tomofumi Okuno,
Hitoshi Ueno
(Fac. Pharm. Sci., Setsunan Univ.)−52−

Paper only

P-051

Arginyltransferase 1 is a key regulator of human immunodeficiency virus type 1
uncoating.
◯ Ryosuke Okano1, Naoki Kishimoto1, Nobutoki Takamune2, Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ., 2KIDO)

Cellular Responses

Paper only

P-052

The anti-inflammatory effect of glycation products dihydropyrazines◯ Madoka Esaki1, Shunji Itoh2, Masaki Yoshida3, Yuu Miyauchi1, Takumi Ishida4,
Shinji Takechi1(1Fac. Pharm. Sci., Sojo Univ., 2Grad. Sch. Health Sci., Kansai Univ. Health Sci., 3Fac.
Bio-Sci., Nagahama Inst. Bio-Sci. Thechnol., 4Sch. Pharm. at Fukuoka, Intl. Univ.
Health and Welfare.)P-053

Molecular and pathological mechanisms of the trans -fatty acid-mediated agerelated diseases○ Yusuke Hirata, Aya Inoue, Ryo Ashida, Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-054

Elucidation of the novel mechanisms by which gefitinib initiates inflammatory side
effects◯ Tomohiro Kagi, Rio Naganuma, Yuto Sekiguchi, Yusuke Hirata, Takuya Noguchi,
Atsushi Matsuzawa(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-055

Mechanism of injury by CD36-mediated fatty acid uptake in renal tubularepithelial cells◯ Yasushi Kawasaki, Mei Kaneko, Miho Karimazawa, Yuki Katsumata,
Akinori Sugiyama(Sch. Pharm., Iwate Med. Univ.)

P-056

Intracellular behavior of lysosomal hydrolases in lysosomal membrane
permeabilization◯ Ayaka Yabuki1, Masatsugu Miyara1,2,3, Kanae Umeda1, Natsumi Okada1,
Namiko Watanabe1, Yaichiro Kotake1(1Grad. Sch. Biomed. and Health Sci., Hiroshima Univ., 2Gifu Pharm. Univ., 3JSPS
Research Fellow PD)

P-057

The role of RhoJ, a member of Rho GTPase, in TGF-β1 mediated EMT◯ Misa Nozaki1, Makoto Nishizuka1,2(1Grad. Sch. Sustain. Community Stud., Hirosaki Univ., 2Fac. Agri. and Life Sci.,
Hirosaki Univ.)−53−

Paper only

P-058

Signal transduction in enteroendocrine cells evoked by ethyl ferulate.
◯ Yoko Mori1, Akira Aoki1, Yoshinori Okamoto1, Takashi Isobe2, Susumu Ohkawara2,
Nobumitsu Hanioka2, Toshiko Tanaka-Kagawa2, Hideto Jinno1(1Fac. Pharm., Meijo Univ., 2Yokohama Univ. Pharm.)

P-059

Enhanced reactivity of basophils to IgE/antigen stimulation induced by T celldependent manner◯ Takuma Kitano1, Keitaroh Kishida1, Yuka Matsui1, Shinsuke Taki2, Saotomo Itoh1,
Shigeaki Hida1(1Grad. Sch. Pharm. Sci. Nagoya City Univ., 2Sch. Med, Shinshu Univ.)

P-060

Changes of selenoprotein gene expression level in mouse neural cells caused by theoxidative stress◯ Tomofumi Okuno1, Yuta Nozaki1, Tomohiro Arakawa2, Hirofumi Ogino1,
Hitoshi Ueno1(1Fac. Pharm. Sci., Setsunan Univ., 2Hamamatsu Univ. Sch. Med.)

P-061

The mast cell-neutrophil crosstalk regulates allergic responses.
◯ Moeri Nakamura1, Naohide Hirashima2, Ryo Suzuki1(1Fac. Pharm. Sci., Inst. Med. Pharm. Health Sci., Kanazawa Univ., 2Grad. Sch. Pharm.
Sci., Nagoya City Univ.)

P-062

The chemical pollutants, Benzo[a]pyrene, regulate NLRP1 inflammasomemediated inflammatory responses in lung epithelium cell.
〇 Risa Kohno, Ryo Suzuki(Fac. Pharm. Sci., Inst. Med. Pharm. Health Sci., Kanazawa Univ.)

P-063

The Cytotoxic Effects of Metallic Nanoparticle in Alveolar Macrophages◯ Minami Satake1, Takafumi Seto2,3, Ryo Suzuki1,3(1Fac. Pharm. Sci., Inst. Med. Pharm. Health Sci., Kanazawa Univ., 2Inst. Sci. Eng.,
Kanazawa Univ., 3CREST)

P-064

FOXA1 is a factor involved in reducing the toxicity of arsenite◯ Daigo Sumi1, Ai Takase1, Rio Fujinaga1, Seiichiro Himeno2(1Sch. Pharm., Tokushima Bunri Univ., 2 Sch. Pharm., Showa Univ.)

P-065

Regulation of reactive sulfur species-producing enzyme expression by TGF-β1 invascular endothelial cells◯ Musubu Takahashi1, Tomoya Fujie2, Akane Takahasshi1, Chika Yamamoto2,
Toshiyuki Kaji1(¹Fac. Pharm. Sci., Tokyo Univ. Sci., ²Fac. Pharm. Sci., Toho Univ.)−54−

P-066

Induction of a reactive sulfur species-production enzyme CSE by FGF-2 invascular endothelial cells◯ Ayaka Kubota1, Musubu Takahashi1, Tomoya Fujie2, Chika Yamamoto2,
Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Fac. Pharm. Sci., Toho Univ.)

P-067

Screening of novel potentiate agent of ligand-mediated activation of AhR◯ Naoteru Denta1, Kentarou Shiina1, Syunsuke Tomita1,2, Masashi Sekimoto1,2(1Sch. Environ. Life Sci., Azabu Univ., 2Grad. Sch. Environ. Health, Azabu Univ.)

P-068

Mechanism of AhR protein degradation by AG1024, an inhibitor for both insulin
like growth factor 1 receptor (IGF1R) and insulin Receptor (INSR)◯ Shunsuke Tomita1,2, Kazuho Inaba1,2, Osamu Endo1, Masasi Sekimoto1(1Sch. Environ. Life Sci., Azabu Univ., 2Grad. Sch. Environ. Health, Azabu Univ.)

P-069

Regulation of EMT related transcriptional factor Snail expression by the
deubiquitinating enzyme USP28◯ Haruna Nakamoto, Koichi Sato, Hitomi Tanaka, Manaka Yoshida,
Chiharu Miyajima, Yasumichi Inoue, Hidetoshi Hayashi(1Grad. Sch. Pharm. Sci., Nagoya City Univ.)

Paper only

P-070

Autoinflammatory diseases caused by impaired membrane traffic◯ Emari Ogawa1, Kojiro Mukai2, Hiroyuki Arai3, Nozomu Kono1, Jyunken Aoki1,
Tomohiko Taguchi2,4(1Grad. Sch. Pharm. Sci., Univ. Tokyo, 2Grad. Sch. Life Sci., Tohoku Univ., 3Grad. Sch.
Med., Univ. Tokyo, 4AMED-PRIME)

Paper only

P-071

Interindividual difference in the expression levels of molecules related to airway
hyperreactivity in human trachea and lung
◯ Natsumi Cho1, Ayano Kondo1, Nozomi Akiyama1, Ikuo Kawamura1,
Nobuhiko Miura1, Yoko Mori2, Moeko Nagai2, Takashi Isobe1, Susumu Ohkawara1,
Nobumitsu Hanioka1, Hideto Jinno2, Toshiko Tanaka-Kagawa1(1Yokohama Univ. Pharm., 2Fac. Pharm., Meijo Univ.)

Paper only

P-072

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function tomouse microglia◯ Sawako Shindo, Gi-Wook Hwang, Kiyoshi Nagata(Fac. Pharm. Sci., Tohoku Med. Pharm. Univ.)−55−

Biochemistry

Paper only

P-073

Selenium binding protein 1 (Selenbp1) modulates chemical-induced dermatitis.
◯ Takayuki Koga1, Makoto Hiromura1, Yingxia Song2, Tomoki Takeda2, Yuji Ishii2,
Takumi Ishida3, Yuko Kobuke1, Fumio Soeda1, Akihisa Toda1(1Daiichi Univ. Pharm., 2Grad. Sch. Pharm. Sci., Kyushu Univ., 3Fac. Pharm. Sci., Sojo
Univ.)

P-074

Inhibition of SARS-CoV2 cysteine proteases by selenium-containing compounds◯ Yuya Habuka1, Takashi Toyama1, Minkyung Jung2, Tomoaki Ida2, Masanobu Morita2,
Mieko Arisawa1, Takaaki Akaike2, Yoshiro Saito1(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2Grad. Sch. Med., Tohoku Univ.)

P-075

The induction of KLF5 gene expression by 3-methylcholanthrene in humanhepatocellular HepG2 cells◯ Noriko Sanada1, Naoya Yamashita1, Yuichiro Kanno2, Kiyomitsu Nemoto3,
Ryoichi Kizu1(1Fac. Pharm. Sci., Doshisha Womenʼs Coll. Liberal Arts, 2Sch. Pharm. Sci., Univ.
Shizuoka, 3Fac. Pharm. Sci., Toho Univ.)

P-076

An unexpected system for adaptive defense against electrophilic stress in out of cell
◯ Yusuke Onose1, Masahiro Akiyama1,2, Yoshito Kumagai1,2(1Grad. Sch. Med Sci., Tsukuba Univ., 2Fac. Med., Tsukuba Univ.)

P-077

Crosstalk of regulation between syndecan-1 and syndecan-4 expressions invascular endothelial cells○ Arisa Sato1, Takato Hara2, Chika Yamamoto2, Toshiyuki Kaji1(1Fac. Pharm. Sci., Tokyo Univ. Sci., 2Fac. Pharm. Sci., Toho Univ.)

P-078

Identification of proteins in the proximity of phosphatidylinositol 4-phosphate(PI4P)○ Shenwei Ni1, Kojiro Mukai2, Takehiro Suzuki3, Naoshi Dohmae3, Hiroyuki Arai4,
Tomohiko Taguchi2, Nozomu Kono1, Junken Aoki1(1Grad. Sch. Pharm. Sci., Univ. Tokyo, 2Grad. Sch. Life Sci., Tohoku Univ., 3Biomol.
Charact. Unit., RIKEN CSRS, 4Grad. Sch. Med., Univ. Tokyo)−56−

Preventive Pharmacology
Paper only

P-079

The search for molecules involved in the improvement of urination function in
drug-induced menopausal mice based on the effect of an enriched environment◯ Fumio Soeda, Ichiro Kimura, Sumire Kudo, Aki Sato, Takayuki Koga,
Yuko Kobuke, Akihisa Toda
(Daiichi Univ. Pharm.)

P-080

Cytotoxic activities against cancer stem cells of isolated compounds from dried
aerial parts of Petasites japonicus◯ Takahiro Kitagawa, Takahiro Matsumoto, Daisuke Imahori, Youhei Saito,
Yuji Nakayama, Eishi Ashihara, Tetsushi Watanabe(Kyoto Pharm. Univ.)

P-081

Increased UCP-1 expression via Akt/mTOR signaling pathway induced by Alpinia
officinarum rhizome extracts◯ Akira Aoki, Yoko Mori, Yoshinori Okamoto, Hideto Jinno(Fac. Pharm., Meijo Univ.)

P-082

Influence of metallothionein gene knockout by CRISPR-Cas9 gene editing
on differentiation of C2C12 myoblasts into myotubes and skeletal muscle
development.
◯ Yoshito Kadota, Takashige Kawakami, Shinya Suzuki(Fac. Pharm. Sci., Tokushima Bunri Univ.)

P-083

Estimation of inter-individual variability of protein requirement by indicatoramino acid oxidation method◯ Kohsuke Hayamizu, Yuma Aoki, Nobuo Izumo, Makoto Nakano(Yokohama Univ. Pharm.)

AnalysisPaper only

P-084

Analysis of 16 mycotoxins contamination in crude drugs that component of a
kakkonto formula◯ Shota Yoshida, Akira Okonogi, Ryuji Takahashi（Kampo Res. Labs., Kracie Pharma Ltd.）

P-085

Cases of chemical analysis to investigate the cause substance of allergic contact
dermatitis◯ Tsuyoshi Kawakami, Maiko Tahara, Yoshiaki Ikarashi(National Institute of Health Sciences)−57−

P-086

Evaluation of rapid detection kits of stimulants in terms of the false positive
responses◯ Suguru Nabeya1, Noriyuki Suzuki1, Hirotaro Iwase2,3, Yasumitsu Ogra1,2(1Grad. Sch. Pharm. Sci., Chiba Univ., 2Edu. Res. Center Legal Med., Chiba Univ.,
3
Grad. Sch. Med., Univ. Tokyo.)

P-087

Rapid and affordable extraction of serum estrogens utilizing a pipette-tip solidphase extraction system◯ Eri Aizawa, Yoshinori Okamoto, Yoko Mori, Akira Aoki, Hideto Jinno(Fac. Pharm., Meijo Univ.)

Drug Metabolism
P-088

Focusing on a baculovirus-mammalian cell expression system (bac-mam system)
for efficient and safe expressions of drug metabolizing enzyme in HepG2 cells◯ Yuu Miyauchi1,2, Akane Kimura2, Madoka Esaki1, Keiko Fujimoto2, Yuko Hirota2,
Shinji Takechi1, Peter I. Mackenzie3, Yuji Ishii2, Yoshitaka Tanaka2(1Fac. Pharm. Sci. Sojo Univ, 2Grad. Sch. Pharm. Sci., Kyushu Univ., 3Flinders Univ.
Sch. Med.)

P-089

Comprehensive characterization of rat liver UDP-glucuronosyltransferases: major
isoforms participated in mycophenolic acid and acetaminophen glucuronidation◯ Yuka Shimomura1, Hiroki Oki1, Ryohei Yamashita1, Yuu Miyauchi1,
Peter I. Mackenzie2, Yoshitaka Tanaka1, Yuji Ishii1(1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Flinders Univ. Sch. Med.)

P-090

Morphinone, an electrophilic metabolite of morphine, activates the biologicaldefense system in human hepatoma HepG2 cells◯ Kohei Matsuo, Daisuke Aibara, Shigeru Yamano(Fac. Pharm. Sci., Fukuoka. Univ.)

Paper only

P-091

Assessment of mechanism underlying diphenhydramine-induced cardiotoxicity incardiomyocytes◯ Erika Morita1, Seigo Sanoh1,2, Chizuru Imako2, Chieri Fujino1, Yuya Ohtsuki1,
Masatsugu Miyara1,3,4, Katsuhiro Okuda5, Shigeru Ohta1,2,6, Yaichiro Kotake1,2(1Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Pharm. Sci., Hiroshima Univ.,
3
Gifu Pharm. Univ., 4JSPS Research Fellow PD, 5Asahikawa Med. Univ., 6WakayamaMed. Univ.)

Paper only

P-092

Interaction of estrogen sulfotransferase SULT1E1 with oxidized LDL and its
association with atherosclerosis◯ Akira Sato1,2, Hinako Watanabe1, Miyuki Yamazaki1, Eiko Sakurai1,2, Keiichi Ebina1,2(1Fac. Pharm., Iryo Sosei Univ., 2Grad. Sch. Life. Sci. Engineer., Iryo Sosei Univ.)−58−

Health Foods

Paper only

P-093

Production of the thrombolytic enzyme Nattokinase by fermentation of Japaneseradish leaves
Yasuhide Yanagisawa1 , ◯ Risa Murakami1, Tatsumi Adachi1 ,Sawa Naito2,
Chieko Yatagai2, Hiroyuki Sumi2(1Pharm. Sci., Chiba Inst. Sci., 2Life Sci.,Kurashiki Univ. Sci. and the Arts)

P-094

Comparison of amount of soup eaten with instant noodles◯ Fumitoshi Sakazaki(Fac. Pharm., Osaka-Ohtani Univ.)

P-095

Analysis of hypoglycemic effect of ginger extracts on diabetic mouse models◯ Honoka Mori, Akira Aoki, Yoko Mori, Yoshinori Okamoto, Hideto Jinno(Fac. Pharm., Meijo Univ.)

P-096

Safety assessment of L-citrulline oral intake from clinical studies: a systematic
review◯ Yui Kuramochi, Ryo Takahashi, Nobuo Izumo, Makoto Nakano, Kohsuke Hayamizu(Yokohama Univ. Pharm.)

P-097

Safety assessment of L-citrulline oral intake from clinical studies: a systematic
review◯ Mako Tamura, Rina Ikefuku, Takahiro Uchida, Shiori Kobuna, Nobuo Izumo,
Akihide Sumino, Makoto Nakano, Kohsuke Hayamizu(Yokohama Univ. Pharm.)

OthersPaper only

P-098

Researchers’ opinion from Global questionnaire survey on standardization ofexperimental protocol for safety assessment of electromagnetic fields◯ Akira Ushiyama1, Kenji Hattori2, Masateru Ikehata3, Keiji Wada4, Yukihisa Suzuki4(1Nat. Inst. Public Health., 2Meiji Pharm. Univ., 3Railway Tech. Res. Inst. 4Tokyo
Metropolitan Univ.)

P-099

The amount of harmful chemical compounds in mainstream smoke of heated
tobacco products is affected by the heating temperature◯ Yohei Inaba, Shigehisa Uchiyama, Akira Ushiyama(National Institute of Public Health)−59−Paper only

P-100

The in vivo assessment of genotoxicity of intermediate frequency magnetic fields
used for wireless power transfer system◯ Shin Ohtani1, Akira Ushiyama2, Keiji Wada3, Yukihisa Suzuki3, Kazuyuki Ishii1,
Kenji Hattori1(1Meiji Pharm. Univ., 2National Institute of Public Health, 3Tokyo Metropolitan Univ.)

P-101

Computed estimation of cardiotoxicity on chemical compound in crude drugs andKampo medicines◯ Takahiro Uchida, Rina Ikefuku, Shiori Kobuna, Mako Tamura, Akihide Sumino,
Makoto Nakano, Nobuo Izumo, Hideko Sone, Kohsuke Hayamizu(Yokohama Univ. Pharm.)−60−