CURRICULUM VITAE
Harunobu MITSUNUMA
Graduate School of Pharmaceutical Sciences, Prof. Kanai GroupThe University of Tokyo
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Tel: (+81)-3-5841-4833
FAX: (+81)-3-5864-5206
E-mail: h-mitsunuma@mol.f.u-tokyo.ac.jp
Education/Career2010.3 BS
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Under the supervision of Prof. Masakatsu Shibasaki
2012.3 Master
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Under the supervision of Prof. Motomu Kanai
2015.3 Ph.D.
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Under the supervision of Prof. Motomu Kanai
2015.4-2017.10 Research Scientist
Sumitomo Dainippon Pharma Co., Ltd.
Drug Development Chemistry Group I, Drug Development Research Laboratories
2017.10-2017.12 Postdoctoral Fellows
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Under the supervision of Prof. Motomu Kanai
2018.1-present Assistant Professor
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Under the supervision of Prof. Motomu Kanai
2022.10-present JST PRESTO researcher ‘‘Development of Basic Material Conversion
Science for Global Environment’’2012.8-2012.12 Visiting Scientist
Department of Chemistry, University of California, Berkeley
Under the supervision of Prof. John F. Hartwig

Fellowship & Grant
2012.4-2015.3 Research Fellow of the Japan Society for the Promotion of Sciences (DC1)[fellowship]2018.10-2020.9 JSPS Grant-in-Aid for Research Activity Start-up #18H05969,#19K21123 [research grant]
2020.10-2024.3 MEXT Grant-in-Aid for Scientific Research on Transformative Research
Areas (A) #20H05843 [research grant]
2021.4-2023.3 JSPS Grant-in-Aid for Young Scientists #21K15220 [research grant]
2021.10-2023.9 Research Grant from ENEOS [research grant]
2022.4 薬学振興会 基礎的研究助成 [research grant]
2022.10-2026.3 JST PRESTO #JPMJPR2279
Award
2019 Teijin Pharmaceutical Award in Synthetic Organic Chemistry (SSOCJ, Japan)
2020 JISEDAI Symposium Lectureship Award (CSJ, Japan)
Publication
1. Attenuation of α-synuclein aggregation by catalytic photo-oxygenation
Iwai, A.; Nakamura, R.; Tomizawa, I.; Mitsunuma, H.; Hori, Y.; Tomita, T.; Sohma,Y.*; Kanai, M.*

Submitted.
2. Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related
Tau ProteinsUmeda, H.; Sawazaki, T.; Furuta, M.; Suzuki, T.; Kawashima, S. A.; Mitsunuma,H.; Hori, Y.; Tomita, T.; Sohma, Y.; Kanai, M.*

Submitted.
3. Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition
Reaction of α-Silyl Amines with Benzalmalononitriles
Katayama, Y.; Mitsunuma, H.*; Kanai, M.*

Chem. Pharm. Bull. 2022, 70, 765-768.

4. Linear-Selective Allylation of Aldehydes with Simple Alkenes Mediated byQuadruple Hybrid Catalysis
Irie, Y.; Chen, H.; Fuse, H.; Mitsunuma, H.*; Kanai, M.*

Adv. Synth. Catal. 2022, 364, 3378-3383.
*Special Issue: Dedicated to Andreas Pfaltz.

5. Site-Selective α-Alkylation of 1,3-Butanediol Using a Thiophosphoric Acid Hydrogen
Atom Transfer Catalyst
Nakao, H.; Mitsunuma, H.*; Kanai, M.*

Chem. Pharm. Bull. 2022, 70, 540-543.

6. A Catalytic Alkylation of Ketones via sp3 C–H Bond Activation
Peng, X.; Hirao, Y.; Yabu, S.; Sato, H.; Higashi, M.; Akai, T.; Masaoka, S.;
Mitsunuma, H.*; Kanai, M.*

J. Org. Chem. 2022, ASAP. DOI: 10.1021/acs.joc.2c00603

7. Identification of a Self-Photosensitizing Hydrogen Atom Transfer OrganocatalystSystemFuse, H.; Irie, Y.; Fuki, M.; Kobori, Y.; Kato, K.; Yamakata, A.; Higashi, M.;
Mitsunuma, H.*; Kanai, M.*

J. Am. Chem. Soc. 2022, 144, 6566-6574.
* Highlighted by Department News release, JACS Spotlights.

8. Titanium(IV) Chloride-Catalyzed Photoalkylation via C(sp3)–H Bond Activation ofAlkanes
Yamane, M.; Kanzaki, Y.; Mitsunuma, H.*; Kanai, M.*

Org. Lett. 2022, 24, 1486-1490.

9. Data-driven catalyst optimization for stereodivergent asymmetric synthesis byiridium/boron hybrid catalysisChen, H.; Yamaguchi, S.*; Morita, Y.; Nakao, H.; Zhai, X.; Shimizu, Y.; Mitsunuma,H.*; Kanai, M.*

Cell Rep. Phys. Sci. 2021, 3, 100679.
*Highlighted by Department News release, 日刊工業新聞, 化学工業日報, 日本経済新聞.

10. A 4-hydroxyproline/trimethyl borate system for asymmetric synthesis of triple
aldols from double aldol cyclic hemiacetals
Hirao, Y.; Kanzaki, Y.; Mitsunuma, H.*; Kanai, M.*

Tetrahedron 2021, 98, 132448.

11. Siloxy Esters as Traceless Activators of Carboxylic Acids: Boron-CatalyzedChemoselective Asymmetric Aldol Reaction
Fujita, T.; Yamane, M.; Sameera, W. M. C.; Mitsunuma, H.*; Kanai, M.*

Angew. Chem. Int. Ed. 2021, 60, 24598-24604.

12. Chromium-Catalyzed Linear-Selective Alkylation of Aldehydes with Alkenes
Hirao, Y.; Katayama, Y.; Mitsunuma, H.*; Kanai, M.*

Org. Lett. 2020, 22, 8584-8588.

13. Photocatalytic

redox-neutralhydroxyalkylationofN-heteroaromatics

withaldehydes
Fuse, H.; Nakao, H.; Saga, Y.; Fukatsu, A.; Kondo, M.; Masaoka, S.: Mitsunuma,H.*; Kanai, M.*

Chem. Sci. 2020, 11, 12206-12211.
*Highlighted by Synfacts 2021, 17, 0084.

14. Catalytic Allylation of Aldehydes Using Unactivated Alkenes
Tanabe, S.; Mitsunuma, H.*; Kanai, M.*

J. Am. Chem. Soc. 2020, 142, 12374-12381.
*Highlighted by Department News release.

15. Catalytic Acceptorless Dehydrogenation of Aliphatic Alcohols.
Fuse, H.; Mitsunuma, H.*; Kanai, M.*

J. Am. Chem. Soc. 2020, 142, 4493-4499.
*Highlighted by Department News release.

16. Copper(I)-Catalyzed Stereodivergent Propargylation of N-Acetyl Mannosamine forProtecting Group Minimal Synthesis of C3-Substituted Sialic Acids
Ishizawa, K.; Majima, S.; Wei, X.-F.; Mitsunuma, H.; Shimizu, Y.; Kanai, M.

J. Org. Chem. 2019, 84, 10615-10628.

17. Amine-Tethered Phenylboronic Acid-Enabling Ring-Opening Strategy for Carbon
Chain Elongation from Double Aldol Cyclic Hemiacetals
Kanzaki, Y.; Hirao, Y.; Mitsunuma, H.*; Kanai, M.*

Org. Biomol. Chem. 2019, 17, 6562-6565.
* Invited to Synthetic methodology in OBC and Trends in Organoboron Chemistry.

18. Catalytic Asymmetric Allylation of Aldehydes with Alkenes Mediated by
Organophotoredox and Chiral Chromium Hybrid Catalysis
Mitsunuma, H.*; Tanabe, S.; Fuse, H.; Ohkubo, K.; Kanai, M.*

Chem. Sci. 2019, 10, 3459-3465.
*Highlighted by UT press release, Chem.Sci. Special Movie, 日経産業新聞*Selected as 2019 Chemical Science HOT Article Collection and 2019 ChemSci Pickof the Week Collection

*Selected as Inside Front Cover

19. Acceptorless Dehydrogenation of Hydrocarbons by Noble-Metal-Free HybridCatalyst System
Fuse, H.; Kojima, M.; Mitsunuma, H.; Kanai, M.

Org. Lett. 2018, 20, 2042-2045.

20. Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for theRapid and Flexible Synthesis of 1,3-Polyols.
Lin. L.; Yamamoto, K.; Mitsunuma, H.; Kanzaki, Y.; Matsunaga, S.; Kanai, M.

J. Am. Chem. Soc. 2015, 137, 15418-15421.

21. Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, andCalycanthine via Double Michael Reaction of Bisoxindole
Mitsunuma, H.; Shibasaki, M.; Kanai, M.; Matsunaga, S.

Angew. Chem. Int. Ed. 2012, 51, 5217-5221.

22. Dinuclear Ni2-Schiff base complex-catalyzed asymmetric 1,4-addition of β-ketoesters to nitroethylene toward γ2,2-amino acid synthesis
Mitsunuma, H.; Matsunaga, S.

Chem. Commun. 2011, 47, 469-471.

23. Catalytic Asymmetric Synthesis of 3-Aminooxindoles: Enantiofacial Selectivity
Switch in Bimetallic vs Monometallic Schiff Base Catalysis
Mouri, S.; Chen, Z.; Mitsunuma, H.; Furutachi, M.; Matsunaga, S.; Shibasaki, M.

J. Am. Chem. Soc. 2010, 132, 1255-1257.

24. A Homodinuclear Mn(III)2-Schiff Base Complex for Catalytic Asymmetric
1,4-Additions of Oxindoles to Nitroalkenes.
Kato, Y.; Furutachi, M.; Chen, Z.; Mitsunuma, H.; Matsunaga, S.; Shibasaki, M.

J. Am. Chem. Soc. 2009, 131, 9168-9169.

Review
1. Recent Progress of Chromium-Mediated Carbonyl Addition Reactions
Katayama, Y.; Mitsunuma, H.*; Kanai, M.*

Synthesis 2021, 54, 1684-1694. [review]

References
Motomu Kanai, Ph.D., Professor
Graduate School of Pharmaceutical Sciences, The University of Tokyo
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Tel: (+81)-3-5841-4830
FAX: (+81)-3-5864-5206
E-mail: kanai@mol.f.u-tokyo.ac.jp
Shigeki Matsunaga, Ph.D., Professor
Faculty of Pharmaceutical Sciences, Hokkaido University
Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan
Tel: (+81)-11-706-3236
FAX: (+81)-11-706-4981
E-mail: kanai@mol.f.u-tokyo.ac.jp