Form 1

2018 Report Form for Collaboration withResearch Center for Biomedical Engineering

Year/month/date
Numberdate:

Date /Month/Year
15/03/2019

To Chairman, Board of Directors, Research Center for Biomedical Engineering

Affiliation
Title
Name
Address

Phone
Fax
E-mailApplicant
Karlsruhe Institute of Technology (KIT)
Head of Department
Accelerator Research and Development + Operations II
Bründermann, ErikKIT CN IBPT Bldg. 345
Hermann-von-Helmholtz-Platz 1
D-76344 Eggenstein-Leopoldshafen, Germany+49 721 608 28576+49 721 608 26789
erik.bruendermann@kit.edu
Report Form for Collaboration Research（和）生体医歯検査応用のための非侵襲・非破壊テラヘルツイメージング技術の研究
Research Theme

Research Area

Research Period（英）Non-invasive and non-destructive terahertz imaging for diagnostics and bio-medicalapplications
1. Biomaterials
2. Bioengineering
3. Functional molecules
4 . Chemistry/Electrical Engineering/Mechanical Engineering/Materials Science○
From:Date/month/Year
To: Date/month/Year
14/05/2018
31/03/2019

Applicant Organization
Name

Department

Title

Role

Bründermann, Erik

Karlsruhe Institute of Technology (KIT),
Institute for Beam Physics and Technology(IBPT)Head ofDepartment, Dr.

Project leader

Hiromoto, Norihisa

Shizuoka University, Graduate School ofscience and technologyProfessor, Dr.

Collaborator(Measurement)

Tripathi, Saroj

Shizuoka University, Faculty of Engineering

Associate
Professor, Dr.

Collaborator(Analysis)

Collaboration Partners
Research Centerinthe静岡大学電子工学研究所 ナノシステム集積化分野 教授
猪川 洋
Research Institute of Electronics, Shizuoka University
Professor Dr. Inokawa, Hiroshi

Research Results (Including Purpose, Results, Figures, etc.)
Accelerator, especially plasma accelerator development (Fig.1) supports a new class of compact particle and lightsources for science and medical research (1) (Fig. 2). Stable conditions for terahertz (THz) light sources anddetector systems as well as ease of operation is required. This includes room-temperature operation and array
technologies to enable a sufficient throughput (2). The latter provides meaningful statistics, which is mandatory in
medical purpose (Fig. 3). The research objective in this Cooperative Research Project No. 2045 is to explore anddevelop new terahertz techniques and detector technologies (3), the latter at the Research Institute of Electronics(RIE) at Shizuoka University (SU), to identify and test suitable THz detector systems for diagnostics andbio-medical applications at accelerator and laser facilities at Karlsruhe Institute of Technology (KIT).
In 2018, the detector technology has progressed by identifying suitable metals and geometries such as meander
structures (Fig. 4) (3), which enable better performance and sensitivity. This detector technology has the potential
to provide multi-pixel arrays for spectral imaging applications to enable high throughput. In addition,
telecommunication technology components (4) can provide the building blocks for compact and robust THz
systems, for example, to detect THz pulses in single-shot mode at very high repetition rates. At KIT a highthroughput terahertz imaging medical (TMed) facility (1) is in the process of being build-up (Fig. 5).

Storage ring
repetition rate
multiplier1,000,000

50 MeV
electron sourceTHzpulse

THz photons

detectortbio-materials
cells, tissue, …

t

Fig.2: Tomography techniques to the terahertz(THz) realm@7 MHz repetition rate

Fig. 1: Electron beam-based source. Refs. (1), (2)pulsehigh power

t

NxN
pixel

THz/IR
spectrahigh repetition rateunlimited DAQ

fbiological t0 x N x Nmattert1 x N x N……

Fig.3: Electron beam-based sources can provide sufficient
light power for medical imaging to illuminate THz
arrays at high frame rate and for systematic studies.
(a)Fig. 4: A pixel of terahertz array .
Ref. (3)(b)

Fig. 5: Accelerator- and laser-based terahertz sources for detector array R&D(a) KIT short-pulse linac test facility and THz source (FLUTE)(b) Using telecommunication technology for terahertz generation. Ref. (4)List of Publications Related to the Collaboration ResearchA. Banerjee, H. Satoh, Y. Sharma, N. Hiromoto and H. Inokawa, "Characterization of platinum and titanium
thermistors for terahertz antenna-coupled bolometer applications," Sensors and Actuators A: Physical.273,
pp.49-57 (Apr. 2018).
Hiromoto, N.; Durgadevi, E.; Baneriee, A.; Satoh, H.; Inokawa, H.; Apriono, C.; Rahardjo, E. T.; Itoh, D.;
Bruendermann, E.; Antenna-Coupled Terahertz Microbolometers with Meander Structures: the Comparison ofTitanium and Platinum Thermistors, 2018. 43rd International Conference on Infrared, Millimeter, and Terahertz
Waves (IRMMW-THz), Nagoya, Japan, 9th-14th September 2018, 1–2, IEEE, Piscataway, NJ.
doi:10.1109/IRMMW-THz.2018.8509929
Bründermann, E.; Müller, A.-S.; Morohashi, I.; Nakajima, S.; Saito, S.; Sekine, N.; Hosako, I.; Compact
Electro-Optical Frequency Tunable Sensors for Accelerator Diagnostics based on Telecommunication Technology.
2018. IRMMW-THz, ibid. doi:10.1109/IRMMW-THz.2018.8510109
Funkner, S.; Blomley, E.; Bründermann, E.; Caselle, M.; Hiller, N.; Nasse, M. J.; Niehues, G.; Rota, L.;
Schönfeldt, P.; Walther, S.; Weber, M.; Müller, A.-S., „High throughput data streaming of individual longitudinal
electron bunch profiles”, 2019. Physical review accelerators and beams, 22 (2), 022801.
doi:10.1103/PhysRevAccelBeams.22.022801

List of Presentations ( Conference, Meeting, etc)

(1) KIT press release (translated from German: www.ibpt.kit.edu/news_2018_11_21_ATHENA_KIT_press_release.php), “Ultra-compact accelerators for science and medical research”, 21 November 2018. YouTube Video:
www.youtube.com/watch?v=BztxS8pbxcM(2) Bründermann, E.; Compact acclerator-based light sources and challenges of terahertz diagnostics anddata-intensive experiments, 26 March 2018, Lecture at Shizuoka University, Hamamatsu Campus.
(3) Hiromoto, N.; Durgadevi, E.; Baneriee, A.; Satoh, H.; Inokawa, H.; Apriono, C.; Rahardjo, E. T.; Itoh, D.;
Bruendermann, E.; Antenna-Coupled Terahertz Microbolometers with Meander Structures: the Comparison of
Titanium and Platinum Thermistors, 2018. 43rd International Conference on Infrared, Millimeter, and Terahertz
Waves (IRMMW-THz), Nagoya, Japan, 9th-14th September 2018, 1–2, IEEE, Piscataway, NJ.
doi:10.1109/IRMMW-THz.2018.8509929(4) Bründermann, E.; Müller, A.-S.; Morohashi, I.; Nakajima, S.; Saito, S.; Sekine, N.; Hosako, I.; Compact
Electro-Optical Frequency Tunable Sensors for Accelerator Diagnostics based on Telecommunication Technology.
2018. IRMMW-THz, ibid. doi:10.1109/IRMMW-THz.2018.8510109

List of Awards

Registration of research-theme continuation for next year
Prior consent from the collaboration partner in the Research Center is necessary.

YesNo

Research plan for the next year (from April 1, 2019 to March 31, 2020), if the collaboration research is continued.
We plan to advance the technologies on THz array and camera as well as stable conditions for THz light sources
to foster systematic studies and statistics for medical researches. High THz source power allows multi-modal,multi-dimensional data for systematic medical imaging with high statistical value. These researches are required
to enable the systematic study of heterogeneous materials such as complex aqueous solutions with biomolecules
relevant to medicine, biocompatible materials, cells and tissue. We also study the techniques for observing
fingerprints of biological matter in the terahertz spectral region mostly terra incognita in which high potential for
discoveries is expected. The methods are to produce pulses with sufficient peak power for transmission and tomanage front of transmitted pulse least affected by scattering & diffraction (quasi-ballistic transmission), which
will enable analysis by regular tomography methods.
This work is conducted in the framework of the 5-year Memorandum of Understanding (MOU) signed between
Karlsruhe Institute of Technology (KIT), Germany, and Shizuoka University, Japan, on November 24th, 2015, andas Cooperative Research of the Research Institute of Electronics for the Research Center of BiomedicalEngineering.