Information for patients prescribed JEMINA® tablets

How to take JEMINA tablets®

What you need to know before you start treatment with JEMINA® tablets-JEMINA® tablets are indicated for dysmenorrhea. You cannot take this medicine to prevent pregnancy.

-JEMINA® tablets are available as 21-tablet sheets and 28-tablet sheets. Please note that each type has a different method ofadministration.
-Keep JEMINA® tablets out of the reach of infants and children. Store the medicine away from light, high temperatures, and moisture.

2 ways to take this medicine:Take this medicine in either of the following schedules: “21-day consecutive treatment with a drug cessation
period of 7 days” or “77-day consecutive treatment with a drug cessation period of 7 days”.
Follow your doctor’s instructions for which way you should take the medicine. (Please check the dosing method

instructed by your doctor.)

21-day consecutive treatment
with a drug cessation period of 7 days

Drugcessation

Drugcessation

77-day consecutive treatment
with a drug cessation period of 7 days

Drugcessation

Drugcessation

followed byfollowed byfollowed bya 7-day
a 7-day
a 7-day
21-day21-day21-dayconsecutive drug-cessation consecutive drug-cessation consecutive drug-cessation
periodperiodperiodtreatment
treatment
treatment

1

Take 1 tablet a day at a fixed time for 21 days in a row.

2

After you finish taking one sheet of 21 tablets, do not take thismedicine for the subsequent 7 days.

3

After the 7-day drug cessation period, repeat the same cycle oftreatment and drug cessation periods.

28-dayconsecutive
treatment

28-dayconsecutive
treatment

21-dayconsecutive
treatment

followed by
a 7-day
drug-cessation
period1

Take 1 tablet a day at a fixed time for 77 days in a row.

2

After taking two sheets of 28 tablets each (that is 56 days in total)
in a row, start taking the tablets contained in a 21-tablet sheet.

3

After you finish taking the tablets in the 21-tablet sheet, do not takethis medicine for the subsequent 7 days.

4

After the 7-day drug cessation period, repeat the same cycle oftreatment and drug cessation periods.

What you need to keep in mind when you take JEMINA® tablets
Notes for when you restart taking JEMINA® tablets
after a drug cessation period of 7 days

Timing to start taking JEMINA® tablets
If you are a new user of this medicine, you will start taking this medicine
between Day 1 and Day 5 of the menstrual cycle.

You may experience bleeding like your period during the drug cessation period.
After a drug cessation period of 7 days, irrespective of termination orcontinuation of bleeding, do start taking a tablet from a new tablet sheet.

What to do when you miss taking JEMINA® tablets:
If you miss a doseat your regulartime of the day,If you notice thatyou missed one or more doses,

immediately take that 1 tablet for the day.

If you missthe previous day’s dose,

immediately take that 1 tablet on the day
before, and also take 1 tablet for the day at yourregular time.

If you miss 2 doses
or more,immediately take that 1 tablet on the day
before, and also take 1 tablet for the day at yourregular time. (Do not take more than 2 tablets a day.)Missedthe previousday<Immediately>
1 tableton the day
before<At regular time>+ for1 tablet
the day

Missed2 days ormore

In any case, continue taking this medicine as in the original schedule from the next day.
If you frequently miss taking this medicine, you will very likely have an atypical genital bleeding. Thus, do take your tablet at about the same time each day.

Nobelpharma Co., Ltd.

Read the reverse page containing important information.

You may have the following symptoms for about 1 to 2 months after
you start taking JEMINA® tablets for the first time.
Breastfullness

Atypical genital
bleedingLowerabdominalpainMildnausea(bleeding that occurs
anytime other thanduring the drugcessation period)

HeadacheIn most cases, the symptoms go away as you continue taking JEMINA® tablets. If the symptoms are severe or last for a long time,
consult with your doctor.

The following symptoms are possible signs of thrombosis*.
(*Disease in which a blood clot blocks a blood vessel)

If any of the symptoms described below occurs, stop taking this medicine and get immediate medical attention at
an emergency medical institution.
● Sudden pain/swelling of legs ● Muscle weakness/paralysis of limbs● Sudden shortness of breath, crushing chest pain ● Severe headache, impaired tongue movement/speaking disorder● Sudden visual disorder (occasional difficulty seeing properly, narrowed vision), etc.

If any of the symptoms described below occurs, stop taking this medicine even if the symptom is mild, and consult
with your doctor immediately.
● Pain/swelling/numbness/flare/warmth in the leg, headache, nausea, vomiting, etc.

If any of the conditions described below occurs, stop taking this medicine even if the symptom is mild, and consultwith your doctor immediately.

Smoking while
taking JEMINA®
tablets may
increase the riskof thrombosis.
Patients shouldstop smoking.
Stopsmoking● Inability to move your body, dehydration, etc.

Thrombosis is likely to occur if you stay in the same position for a long time or if you do not drink
enough water. Get an appropriate amount of exercise and drink water frequently.

Always carry the Portable Patient Card while taking
JEMINA® tablets● Precautions relating to thrombosis are described in “Japanese” on that card.

● Make sure to present this card when you visit other clinical departments or medical institutions.

D2This card is available in Japanese only.

Consult with or report to your doctor if:● You suspect you have become pregnant for any reason, such as having forgotten to take this medicine.

● You continue having severe diarrhea or vomiting. (The active ingredients of this medicine may be difficult to be absorbed.)● You are taking another drug. (There are no concerns when used in combination with topical creams or eye drops.)● You are going to undergo a laboratory test.

● You wish to be pregnant.

● You have other worrisome symptoms.

Follow the instructions given by your doctor and have regular check-ups to confirm progress of your treatment.

Name of the medical institution

Feel free to contact us if you have any question or concern.

Nobelpharma Co., Ltd.
1-17-24, Shinkawa, Chuo-ku, Tokyo 104-0033

ASKA Pharmaceutical Co., Ltd.
2-5-1, Shibaura, Minato-ku, Tokyo, 108-8532
JMN-20E-IFTA
Created in September 2020