2022 年度報告（2022.1～2023.3）
熊本大学大学院生命科学研究部付属健康長寿代謝制御研究センター〇代謝・循環研究部門
1）病態生化学講座
1. Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z,
Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T, Liang X: NAD+ salvage
governs mitochondrial metabolism invigorating NK cell anti-immunity. Hepatology (inpress)
2. Mizutani H, Sato Y, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K: SIRT7
deficiency protects against Aβ42-induced apoptosis through the regulation of NOX4derived reactive oxygen species production in SH-SY5Y cells. Int. J. Mol. Sci 23:
9027. 2022
3. Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y,
Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki
E: Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance andmitochondrial homeostasis through regulation of insulin signaling. Nature
Communications 13: 6092, 2022
4. Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K,
Tamura M, Oike Y, Yamagata K: SIRT7 deficiency protects against aging-associatedglucose intolerance and extends lifespan in male mice. Cells 11: 3609, 2022
5. Yoshizawa T, Sato Y, Sobuz S, Mizumoto T, Tsuyama T, Karim Md, Miyata K, Tasaki
M, Yamazaki M, Kariba Y, Araki N, Araki E, Kajimura S, Oike Y, Braun T, Bober E,
Auwerx J, Yamagata K: SIRT7 suppresses energy expenditure and thermogenesis byregulating brown adipose tissue functions in mice. Nature Communications 13: 7439,
2022

2）分子遺伝学講座
1.

Horiguchi H, Kadomatsu T, Yumoto S, Masuda T, Miyata K, Yamamura S, Sato M,
Morinaga J, Ohtsuki S, Baba H, Moroishi T, Oike Y: Tumor cell-derived ANGPTL2
promotes β-catenin-driven intestinal tumorigenesis. Oncogene 41: 4028-4041, 2022

2.

Zhao W, Morinaga J, Ukawa S, Endo M, Yamada H, Kawamura T, Wakai K, Tsushita
K, Ando M, Suzuki K, Oike Y, Tamakoshi A: Plasma angiopoietin-like protein 2levels and mortality risk among younger-old Japanese people: a population-based
case-cohort study. J Gerontol A Biol Sci Med Sci 77: 1150-1158, 2022

3.

Funasaki S, Mehanna S, Wenjuan Ma, Nishizawa H, Kamikubo Y, Sugiyama H,
Ikeda S, Motoshima T, Hasumi H, Linehan M W, Schmidt S L, Ricketts C, Suda
T, Oike Y, Kamba T, Baba M. Targeting chemoresistance in Xp11.2 translocation
renal cell carcinoma using a novel polyamide-chlorambucil conjugate. Cancer
Sci 113: 2352-2367, 2022

4.

Cui G, Shimba A, Jin J, Ogawa T, Muramoto Y, Miyachi H, Abe S, Asahi T, Taniichi S, Dijkstra J M, Iwamoto Y, Kryukov K, Zhu Y, Takami D, Hara T, Kitano S, Xu
Y, Morita H, Zhang M, Zreka L, Miyata K, Kanaya T, Okumura S, Ito T, Hatano E,
Takahashi Y, Watarai H, Oike Y, Imanishi T, Ohno H, Ohteki T, Minato N, Kubo M,
Holländer G A, Ueno H, Noda T, Shiroguchi K, Ikuta K: A Circulating Subset of
iNKT Cells Mediates Antitumor and Antiviral Immunity. Sci Immunol 7: eabj8760,
2022

5.

Yoshizawa T, Sato Y, Sobuz U.S, Mizumoto T, Tsuyama T, Karim Md.F, Miyata K,
Tasaki M, Yamazaki M, Kaiba Y, Araki N, Araki E, Kajimura S, Oike Y, Braun T,
Bober E, Auwerx J, Yamagata K: SIRT7 suppresses energy expenditure andthermogenesis by regulating brown adipose tissue functions in mice. Nat
Commun 13: 7439, 2022

6.

Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K,
Tamura M, Oike Y, Yamagata K: SIRT7 deficiency extends lifespan in male micewith an increase of fibroblast growth factor 21. Cells 11: 3609, 2022

7.

Okadome Y, Morinaga J, Yamanouchi Y, Matsunaga E, Fukami H, Kadomatsu T,
Horiguchi H, Sato M, Sugizaki T, Hayata M, Sakaguchi T, Hirayama R, Ishimura T,
Kuwabara T, Usuku K, Yamamoto T,Mukoyama M, Suzuki R, Fukui T, Oike Y:
Increased numbers of pre-operative circulating monocytes predict risk of developing
cardiac surgery-associated acute kidney injury in conditions requiring cardio
pulmonary bypass. Clin Exp Nephrol doi: 10.1007/s10157-022-02313-x, Online
ahead of print.

3）代謝内科学講座
1.

Yoshizawa T, Sato Y, Sobuz SU, Mizumoto T, Tsuyama T, Karim MF, Miyata K,
Tasaki M, Yamazaki M, Kariba Y, Araki N, Araki E, Kajimura S, Oike Y, Braun T,
Bober E, Auwerx J, Yamagata K. SIRT7 suppresses energy expenditure andthermogenesis by regulating brown adipose tissue functions in mice. Nature
Communications 13(1):7439, 2022.

2.

Araki H, Matsumura T, Furukawa N, Araki E. Updates of incretin-related drugs forthe treatment of type 2 diabetes. Journal of Diabetes Investigation. 2022. In press.

3.

Sakaguchi M, Okagawa S, Okubo Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa
T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E.
Phosphatase Protector Alpha4 (α4) is involved in Adipocyte Maintenance andMitochondrial Homeostasis through Regulation of Insulin Signaling. Nature
Communications 13(1):6092, 2022.

4.

Araki E, Harashima S, Nishida T, Nakamura J: Efficacy and safety of once-weekly
semaglutide in Japanese individuals with type 2 diabetes in the SUSTAIN 1, 2, 5 and9 trials: Post-hoc analysis. Journal of Diabetes Investigation 13(12):1971-1980,
2022.

5.

Araki E, Sakaguchi M, Fukuda K, Kondo T: Potential of a glucagon-like peptide-1
receptor/glucose-dependent insulinotropic polypeptide receptor/glucagon receptor
triagonist for the treatment of obesity and type 2 diabetes. Journal of Diabetes

Investigation 13(12):1958-1960, 2022.
6.

Saishouji F, Maeda S, Hamada H, Kimura N, Tamanoi A, Nishida S, Sakaguchi M,
Igata M, Yokoo K, Kawakami F, Araki E, Kondo T. Ectopic ACTH-producing
neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma:a case report. BMC Endocrine Disorders 22(1):184, 2022.

7.

Matsumura T, Makabe T, Ueda S, Fujimoto Y, Sadahiro K, Tsuruyama S, Ookubo Y,
Kondo T, Araki E. Clinical Benefit of Switching from Low-Dose to High-Dose
Empagliflozin in Patients with Type 2 Diabetes. Diabetes Therapy 13(9):1621-1634,
2022.

8.

Horikawa C, Tsuda K, Oshida Y, Satoh J, Hayashino Y, Tajima N, Nishimura R,
Sone H, JDCP Study Group (Araki E. et al.). Dietary intake and physical activity inJapanese patients with type 2 diabetes: the Japan Diabetes Complication and its
Prevention prospective study (JDCP study 8). Diabetology International 13(2):344357, 2022.

9.

Naito H, Sueta D, Hanatani S, Ikeda H, Hirosue A, Senokuchi T, Araki E, Tsujita K,
Nakayama H, Kasaoka S. Factors Affecting Human Damage in Heavy Rains andTyphoon Disasters. The Tohoku Journal of Experimental Medicine 256(2):175-185,
2022.

10. Ogawa W, Araki E, Ishigaki Y, Hirota Y, Maegawa H, Yamauchi T, Yorifuji T,
Katagiri H. New classification and diagnostic criteria for insulin resistance syndrome.
Endocrine Journal 69(2):107-113, 2022.
11. Ogawa W, Araki E, Ishigaki Y, Hirota Y, Maegawa H, Yamauchi T, Yorifuji T,
Katagiri H. New classification and diagnostic criteria for insulin resistance syndrome.
Diabetology Intl 13:337-343, 2022.
12. Ikeda T, Ishihara A, Mitsumasu S, Yamanouchi Y, Kanemaru H, Sakakida K,
Morinaga J, Araki E. Questionnaire Survey Regarding Troubles and Concerns

Related to Clinical Research Based on the Clinical Trial Act for Clinicians andAcademics. The Kurume Medical Journal 67(1):17-21, 2022.
13. Araki H, Hino S, Anan K, Kuribayashi K, Etoh K, Seko D, Takase R, Kohrogi K,
Hino Y, Ono Y, Araki E, Nakao M. LSD1 defines the fiber type-selective
responsiveness to environmental stress in skeletal muscle. eLife 12: e84618, 2023.
4）循環器内科学講座
1.

Egashira K, Sueta D, Komorita T, Yamamoto E, Usuku H, Tokitsu T, Fujisue K,
Nishihara T, Oike F, Takae M, Hanatani S, Takashio S, Ito M, Yamanaga K, Araki S,
Soejima H, Kaikita K, Matsushita K, Tsujita K. HFA-PEFF Score: A Prognostic
Value in Heart Failure with preserved Left Ventricular Ejection Fraction Patients.
Korean J Intern Med. 37: 96-108, 2022

2.

Egashira K, Sueta D, Kidoh M, Tomiguchi M, Oda S, Usuku H, Hidaka K, GotoYamaguchi L, Sueta A, Komorita T, Oike F, Fujisue K, Yamamoto E, Hanatani S,
Takahsio S, Araki S, Matsushita K, Yamamoto Y, Hirai T, Tsujita K. Cardiac
computed tomography-derived myocardial tissue characterization after anthracycline
treatment. ESC Heart Fail. 9: 1792-1800, 2022

3.

Fujisue K, Yamamoto E, Sueta D, Takae M, Nishihara T, Komorita T, Usuku H,
Yamanaga K, Ito M, Hoshiyama T, Kanazawa H, Takashio S, Arima Y, Araki S,
Soejima H, Kaikita K, Matsushita K, Tsujita K. Increased soluble programed cell
death-ligand 1 is associated with acute coronary syndrome. Int J Cardiol. 349: 1-6,
2022

4.

Hoshiyama T, Sumi H, Kaneko S, Kawahara Y, Ito M, Kanazawa H, Takashio S,
Yamamoto E, Matsushita K, Tsujita K. Placement of catheters without magnetic
sensors in the coronary sinus without fluoroscopic guidance: Feasibility and safety
evaluation. J Arrhythm. 38: 736-742, 2022

5.

Ishii M, Marume K, Nakai M, Ogata S, Kaichi R, Ikebe S, Mori T, Komaki S, Kusaka
H, Toida R, Kurogi K, Ogawa H, Iwanaga Y, Miyamoto Y, Yamamoto N, Tsujita K.

Risk Prediction Score for Cancer Development in Patients with Acute Coronary
Syndrome. Circ J. (in press), 2022
6.

Ishii M, Tsujita K, Okamoto H, Koto S, Nishi T, Nakai M, Sumita Y, Iwanaga Y,
Azuma N, Matoba S, Hirata KI, Hikichi Y, Yokoi H, Ikari Y, Uemura S. Resources
for cardiovascular healthcare associated with 30-day mortality in acute myocardial
infarction with cardiogenic shock. Eur Heart J Open. 2: oeab047, 2022

7.

Ishii M, Kuramitsu S, Yamanaga K, Matsuo H, Horie K, Takashima H, Terai H,
Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T,
Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma
K, Kanemura N, Sonoda S, Yokoi H, Tanaka N, Tsujita K; J- CONFIRM Registry
Investigators. Association of Guideline-Directed Medical Therapy Adherence with
Outcomes After Fractional Flow Reserve-Based Deferral of Revascularization. Eur
Heart Caadiovasc Pharmacother. 3; 8: 600-608, 2022

8.

Ishii M, Kawai T, Tsujita K, Igarashi A, Suzuki M, Deguchi H, Fernandez J. CostEffectiveness of Vonoprazan Compared with Proton Pump Inhibitors in Patients
Taking Low-Dose Aspirin for Secondary Prevention of Cardiovascular Events inJapan. Circ J. (in press), 2022

9.

Kuyama N, Kaikita K, Ishii M, Mitsuse T, Nakanishi N, Fujisue K, Otsuka Y,
Hanatani S, Sueta D, Takashio S, Araki S, Yamamoto E, Matsushita K, Tsujita K.
Increased thrombogenicity is associated with revascularization outcomes in patientswith chronic limb-threatening ischemia. J Vasc Surg. 76: 513-522, 2022

10. Matsushita K, Kojima S, Hirakawa K, Tabata N, Ito M, Yamanaga K, Fujisue K,
Hoshiyama T, Hanatani S, Sueta D, Kanazawa H, Takashio S, Arima Y, Araki S,
Usuku H, Suzuki S, Yamamoto E, Nakamura T, Soejima H, Kaikita K, Tsujita K.
Differential effects of overweight/obesity depending on the severity of heart failure
complicating acute myocardial infarction in Japan. Prog Cardiovasc Dis. (in press),2022

11. Morioka M, Takashio S, Nakashima N, Nishi M, Fujiyama A, Hirakawa K, Hanatani
S, Usuku H, Yamamoto E, Kidoh M, Oda S, Matsushita K, Ueda M, Tsujita K.
Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild-TypeTransthyretin Amyloid Cardiomyopathy. J Am Heart Assoc. 11: e024717, 2022
12. Nakashima N, Takashio S, Morioka M, Nishi M, Yamada T, Hirakawa K, Ishii M,
Tabata N, Yamanaga K, Fujisue K, Sueta D, Kanazawa H, Hoshiyama T, Hanatani S,
Araki S, Usuku H, Yamamoto E, Ueda M, Matsushita K, Tsujita K. A simple staging
system using biomarkers for wild-type transthyretin amyloid cardiomyopathy inJapan. ESC Heart Fail. 9: 1731-1739, 2022
13. Nishi T, Ishii M, Tsujita K, Okamoto H, Koto S, Nakai M, Sumita Y, Iwanaga Y,
Matoba S, Kobayashi Y, Hirata K, Hikichi Y, Yokoi H, Ikari Y, Uemura S. Outcomesof VA-ECMO plus IABP versus VA-ECMO Alone for Treatment of Acute
Myocardial Infarction Complicated by Cardiogenic Shock: Insight from the JROADDPC Registry. J Am Heart Assoc. 11: e023713, 2022
14. Oike F, Usuku H, Yamamoto E, Marume K, Takashio S, Ishii M, Tabata N, Fujisue
K, Yamanaga K, Sueta D, Hanatani S, Arima Y, Araki S, Oda S, Kawano H, Soejima
H, Matsushita K, Ueda M, Fukui T, Tsujita. Utility of Left Atrial and Ventricular
Strain for Diagnosis of Transthyretin Amyloid Cardiomyopathy in Aortic Stenosis.
ESC Heart Fail.9: 1976-1986, 2022
15. Shirahama Y, Tabata N, Sakamoto K, Sato R, Yamanaga K, Fujisue K, Sueta D, Araki
S, Takashio S, Arima Y, Hokimoto S, Sato K, Sakamoto T, Nakao K, Shimomura H,
Matsumura T, Tayama S, Fujimoto K, Oshima S, Nakamura S, Tsunoda R, Hirose T,
Kikuta K, Sakaino N, Yamamoto N, Kajiwara I, Suzuki S, Yamamoto E, Kaikita K,
Matsushita K, Tsujita K; Kumamoto Intervention Conference Study (KICS)
Investigators. Validation of the obesity paradox by body mass index and waist
circumference in patients undergoing percutaneous coronary intervention. Int J
Obes(Lond). 46: 1840-1848, 2022
16. Soejima H, Ogawa H, Morimoto T, Okada S, Matsumoto C, Nakayama M, Masuda

I, Jinnouchi H, Waki M, Saito Y. Kidney function deterioration is dependent on bloodpressure levels: 11.2year follow-up in diabetic patients. Heart Vessels.37: 1873-1881,
2022
17. Sueta D, Yamamoto E, Usuku H, Suzuki S, Nakamura T, Matsui K, Akasaka T,
Shiosakai K, Sugimoto K, Tsujita K; ESES-LVH Study Investigators. Rationale and
Design of the Efficacy and Safety of Esaxerenone in Hypertensive Patients with Left
Ventricular Hypertrophy (ESES-LVH) Study - Protocol for a Multicenter, OpenLabel, Exploratory Interventional Study. Circ Rep. 4: 99-104, 2022
18. Takashio S, Tokitsu T, Matsukawa M, Sakaino N, Fujimoto K, Sakamoto T, Noda K,
Tsunoda R, Misumi I, Hirai N, Doi H, Koide S, Mizuno Y, Hirose T, Kurokawa H,
Kajiwara I, Ohba K, Miyamoto S, Araki S, Yamamoto E, Matsushita K, Ueda
M, Tsujita K; Kumamoto Cardiac Amyloid Survey Investigators. Incidence, clinicalcharacteristics, and diagnostic approach in transthyretin amyloid cardiomyopathy:
The Kumamoto Cardiac Amyloidosis Survey. J Cardiol. 80: 49-55, 2022
19. Usuku H, Takashio S, Yamamoto E, Yamada T, Egashira K, Morioka M, Nishi M,
Komorita T, Oike F, Tabata N, Ishii M, Yamanaga K, Fujisue K, Sueta D, Arima Y,
Araki S, Oda S, Misumi Y, Kawano H, Matsushita K, Ueda M, Matsui H, Tsujita K.
Prognostic value of right ventricular global longitudinal strain in transthyretin
amyloid cardiomyopathy. J Cardiol. 80: 56-63, 2022
20. Usuku H, Yamamoto E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Morioka M,
Komorita T, Oike F, Fujisue K, Hanatani S, Arima Y, Takashio S, Oda S, Kawano H,
Matsushita K, Ueda M, Matsui H, Tsujita K. Time-dependent change of relative
apical longitudinal strain index in patients with wild-type transthyretin amyloid
cardiomyopathy. Int J Cardiol Heart Vasc. 43: 101146
21. Yamamoto E, Sueta D, Tsujita K. Renal denervation in resistant hypertension: A
review of clinical trials and future perspectives. Cardiovasc Interv Ther. 37: 450-457,
2022

22. Ishida T, Arima Y, Mizuno Y, Harada E, Yamashita T, Sueta D, Sakamoto K, Suzuki
S, Kaikita K, Yamada Y, Shimomura H, Oniki K, Saruwatari J, Hokimoto S, Yasue
H, Tsujita K. East Asian variant aldehyde dehydrogenase type 2 genotype
exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction inmen: possible sex differences. Heart Vessels.37: 184-193, 2022
23. Kurogi K, Ishii M, Ikebe S, Kaichi R, Mori T, Komaki S, Yamamoto N, Yamanaga
K, Arima Y, Yamamoto E, Kaikita K, Matsushita K, Tsujita K. Optical coherence
tomography-versus intravascular ultrasound-guided stent expansion in calcified
lesions. Cardiovasc Interv Ther. 37: 312-323, 2022
24. Kurogi K, Ishii M, Sakamoto K, Tsujita K. Observing an Aorto-Ostial Lesion using
TELESCOPE in Optical Coherence Tomography-Guided Percutaneous Coronary
Intervention. EuroIntervention (in press), 2022
25. Nishi M, Takashio S, Morioka M, Fujiyama A, Nakashima N, Hirakawa K, Hanatani
S, Usuku H, Yamamoto E, Kidoh M, Oda S, Gushima R, Matsushita K, Fukushima
S, Ueda M, Tsujita K. Extracardiac Biopsy Sensitivity in Transthyretin Amyloidosis
Cardiomyopathy Patients with Positive 99 m Tc-Labeled Pyrophosphate Scintigraphy
Findings. Circ J. 86: 1113-1120, 2022
26. Sakamoto K, Sato R, Tabata N, Ishii M, Yamashita T, Nagamatsu S, Motozato K,
Yamanaga K, Hokimoto S, Sueta D, Araki S, Fujisue K, Arima Y, Takashio S,
Fujimoto K, Shimomura H, Tsunoda R, Hirose T, Sato K, Kikuta K, Sakaino N,
Nakamura S, Yamamoto N, Matsumura T, Kajiwara I, Tayama S, Sakamoto T, Nakao
K, Oshima S, Yamamoto E, Kaikita K, Tsujita K; Kumamoto Intervention
Conference Study (KICS) Investigators. Temporal trends in coronary intervention
strategies and the impact on one-year clinical events: data from a Japanese multicenter real-world cohort study. Cardiovasc Interv Ther. 37: 66-77, 2022
27. Shirakawa T, Fujisue K, Nakamura S, Yamamoto N, Oshima S, Matsumura T,
Tsunoda R, Hirai N, Koide S, Tayama S, Kikuta K, Hirose T, Maruyama H, Fujimoto
K, Kajiwara I, Sakamoto T, Nakao K, Sakaino N, Nagayoshi Y, Hokamaki J,

Shimomura H, Sakamoto K, Yamamoto E, Izumiya Y, Kaikita K, Hokimoto S,
Ogawa H, Tsujita K; INVITATION study investigators. Dose-Dependent Inhibitory
Effect of Rosuvastatin in Japanese Patients with Acute Myocardial Infarction on
Serum Concentration of Matrix Metalloproteinases-INVITATION Trial. J
Atheroscler Thromb. 29: 229-241, 2022
28. Yamashita T, Arima Y, Hoshiyama T, Tabata N, Sueta D, Kawahara Y, Ito M,
Kanazawa H, Ishii M, Yamanaga K, Hanatani S, Takashio S, Araki S, Suzuki S,
Yamamoto E. Kaikita K, Oniki K, Saruwatari J, Matsushita K, Tsujita K. Effect of
the ALDH2 Variant on the Prevalence of Atrial Fibrillation in Habitual Drinkers.
JACC:Asia.2: 62-70, 2022
29. Ahmed K, Arima Y, Tabata N, Ishii M, Sato R, Yamashita T, Yamanaga K, Takizawa
H, Hokimoto S, Sueta D, Araki S, Fujisue K, Takashio S, Fujimoto K, Shimomura H,
Tsunoda R, Hirose T, Sato K, Kikuta K, Sakaino N, Nakamura S, Yamamoto N,
Matsumura T, Kajiwara I, Tayama S, Sakamoto T, Nakao K, Oshima S, Yamamoto
E, Sakamoto K, Kaikita K, Matsushita K, Tsujita K. Impact of cerebrovascularcomorbidity on prognosis in Japanese patients undergoing PCI: 1-year data fromJapanese multicenter registry (KICS). Heart Vessels. 37: 911-918, 2022
（総説）
1.

Hirakawa K, Yamamoto E, Takashio S, Hanatani S, Araki S, Suzuki S, Kaikita K,
Matsushita K, Ogo T, Tsujita K. Balloon pulmonary angioplasty in chronic
thromboembolic pulmonary hypertension. Cardiovasc Interv Ther. 37: 60-65, 2022

2.

Yamamoto E, Sueta D, Tsujita K. Renal denervation in resistant hypertension: areview of clinical trials and future perspectives. Cardiovasc Interv Ther. 37: 450-457,20225）細胞病理学講座
1.

Yagita K, Noguchi H, Koyama S, Hamasaki H, Komori T, Aishima S, Kosaka T,
Ueda M, Komohara Y, Watanabe A, Sasagasako N, Ninomiya T, Oda Y, Honda
H.Chronological Changes in the Expression Pattern of Hippocampal Prion Proteins

During Disease Progression in Sporadic Creutzfeldt-Jakob Disease
MM1 Subtype. J Neuropathol Exp Neurol. 81:900-909, 2022
2.

Yamakawa M, Nakane S, Ihara E, Tawara N, Ikeda H, Igarashi Y, Komohara Y,
Takamatsu K, Ikeda T, Tomita Y, Murai S, Ando Y, Mukaino A, Ogawa Y, Ueda M.
A novel murine model of autoimmune dysautonomia by α3 nicotinic acetylcholine
receptor immunization. Front Neurosci. 16:1006923, 2022.

3.

Kanemaru A, Shinriki S, Kai M, Tsurekawa K, Ozeki K, Uchino S, Suenaga N,
Yonemaru K, Miyake S, Masuda T, Kariya R, Okada S, Takeshita H, Seki Y, Yano H,
Komohara Y, Yoshida R, Nakayama H, Li JD, Saito H, Jono H.
Potential use of EGFR-targeted molecular therapies for tumor suppressor CYLDnegative and poor prognosis oral squamous cell carcinoma with chemoresistance.
Cancer Cell Int. 22:358, 2022

4.

Morinaga T, Iwatsuki M, Yamashita K, Matsumoto C, Harada K, Kurashige J,
Iwagami S, Baba Y, Yoshida N, Komohara Y, Baba H. Evaluation of HLA-E
Expression Combined with Natural Killer Cell Status as a Prognostic Factor for
Advanced Gastric Cancer.

5.

Ann Surg Oncol. 29:4951-4960, 2022

Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A,
Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S,
Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama
H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing
lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration.
Cancer Immunol Immunother. 71:2127-2139, 2022

6.

Saito Y, Fujiwara Y, Shinchi Y, Mito R, Miura Y, Yamaguchi T, Ikeda K, Urakami S,
Nakashima Y, Sakagami T, Suzuki M, Tabata Y, Komohara Y.
Classification of PD-L1 expression in various cancers and macrophages based on
immunohistocytological analysis. Cancer Sci. 113:3255-3266, 2022

7.

Matsubara E, Komohara Y, Esumi S, Shinchi Y, Ishizuka S, Mito R, Pan C, Yano H,

Kobayashi D, Fujiwara Y, Ikeda K, Sakagami T, Suzuki M.SPP1 Derived fromMacrophages Is Associated with a Worse Clinical Course and Chemo-Resistance inLung Adenocarcinoma. Cancers (Basel). 14:4374, 2022.
8.

Yamane T, Kanamori Y, Sawayama H, Yano H, Nita A, Ohta Y, Hinokuma H, Maeda
A, Iwai A, Matsumoto T, Shimoda M, Niimura M, Usuki S, Yasuda-Yoshihara N,
Niwa M, Baba Y, Ishimoto T, Komohara Y, Sawa T, Hirayama T, Baba H, Moroishi
T. Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in
macrophages and is associated with colorectal cancer progression. JCI Insight.
e156802, 2022.

9.

Li L, Irie T, Yoshii D, Komohara Y, Fujiwara Y, Esumi S, Kadohisa M, Honda M,
Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T. M-CSFR expression in the embryonal
component of hepatoblastoma and cell-to-cell interaction between macrophages andhepatoblastoma. Med Mol Morphol. 55:236-247, 2022

10. Yano H, Fujiwara Y, Hasita H, Pan C, Kai K, Niino D, Ohsawa K, Higashi M, Nosaka
K, Okuno Y, Tamaru JI, Mukasa A, Matsuoka M, Komohara Y. Blocking cholesterol
efflux mechanism is a potential target for anti-lymphoma therapy. Cancer Sci.
113:2129-2143, 2022
11. Irie T, Yoshii D, Komohara Y, Fujiwara Y, Kadohisa M, Honda M, Suzu S, Matsuura
T, Kohashi K, Oda Y, Hibi T.. IL-34 in hepatoblastoma cells potentially promotetumor progression via autocrine and paracrine mechanisms. Cancer Med. 11:14411453, 2022
12. Tsukamoto H, Komohara Y, Tomita Y, Miura Y, Motoshima T, Imamura K, Kimura
T, Ikeda T, Fujiwara Y, Yano H, Kamba T, Sakagami T, Oshiumi H.
Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes
to anti-PD-1 therapy-induced adverse events. Proc Natl Acad Sci U S A.
119:e2205378119, 2022.
13. Yonemitsu K, Pan C, Fujiwara Y, Miyasato Y, Shiota T, Yano H, Hosaka S, Tamada

K, Yamamoto Y, Komohara Y. GM-CSF derived from the inflammatory
microenvironment potentially enhanced PD-L1 expression on tumor-associatedmacrophages in human breast cancer. Sci Rep. 12:12007, 2022.
14. Okadome K, Baba Y, Yasuda-Yoshihara N, Nomoto D, Yagi T, Toihata T, Ogawa K,
Sawayama H, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N,
Watanabe M, Komohara Y, Baba H. PD-L1 and PD-L2 expression status in relation
to chemotherapy in primary and metastatic esophageal squamous cell carcinoma.
Cancer Sci. 113:399-410, 2022
15. Pan C, Fujiwara Y, Horlad H, Iriki T, Shiraishi D, Komohara Y. Cyclic sulfur
compounds targeting macrophage polarization into M2/protumor phenotype andtheir anti-tumor effects. Cancer Immunol Immunother. 71:1331-1343, 2022.
16. Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome K, Harada K, Ishimoto T, Iwatsuki
M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Moroishi T, Komohara Y,
Sawa T, Baba H. Fusobacterium nucleatum promotes esophageal squamous cell
carcinoma progression via the NOD1/RIPK2/NF-κB pathway.
Cancer Lett. 530:59-67, 2022.
17. Shinchi Y, Ishizuka S, Komohara Y, Matsubara E, Mito R, Pan C, Yoshii D,
Yonemitsu K, Fujiwara Y, Ikeda K, Tamada K, Sakagami T, Suzuki M. The
expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms
in lung adenocarcinoma. Cancer Immunol Immunother. 29:1-17, 2022.
18. Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y,
Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono
H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K. Resistance tochemical carcinogenesis induction via a dampened inflammatory response in naked
mole-rats. Commun Biol. 30;287, 2022.
19. Harada M, Iida Y, Kotani H, Minami T, Komohara Y, Eto M, Yoshikawa K, Uemura
H. T-cell responses and combined immunotherapy against human carbonic anhydrase9-expressing mouse renal cell carcinoma. Cancer Immunol Immunother. 71:339-352,
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20. Yoshii D, Shimata K, Yokouchi Y, Komohara Y, Suda H, Honda M, Yamamura K,
Hibi T, Inomata Y. SOX9 contributes to the progression of ductular reaction for theprotection from chronic liver injury. Hum Cell. 35:721-734, 2022.
21. Nomoto D, Baba Y, Okadome K, Yagi T, Kalikawe R, Kiyozumi Y, Harada K, Eto K,
Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N,
Komohara Y, Watanabe M, Baba H. Prognostic impact of PD-1 on tumor infiltrating
lymphocytes in 433 resected esophageal cancers. Ann Thorac Surg. 113:286-294,
2022.
22. Yano H, Fujiwara Y, Komohara Y. Cholesterol metabolism and lipid droplet
vacuoles; a potential target for the therapy of aggressive lymphoma. J Clin Exp
Hematop. 2022
23. Nakagaki Y, Kai K, Komohara Y, Takezaki T, Kuroda J, Shinojima N, Shimomura
M, Kawakami F, Mikami Y, Mukasa A. Gliosarcoma with Systemic Metastasis
Showing Favorable Response to Ifosfamide, Carboplatin, and Etoposide
Chemotherapy: An Autopsy Case Report. NMC Case Rep J. 9:263-268, 2022.
24. Uchihara T, Komohara Y, Yamashita K, Arima K, Uemura S, Hanada N, Baba H.
Chronic Appendicitis Caused by a Perforating Fish Bone: Case Report and Brief
Literature Review. In Vivo. 36:1982-1985, 2022.
25. Matsumura K, Yamamura K, Oda E, Akahoshi S, Ishiko T, Miyata T, Miyamoto H,
Motohara T, Sasao A, Komohara Y, Kawano H, Beppu T. Successful Treatment ofIntrahepatic Cholangiocarcinoma With Liver/Lung Metastasis and Peritoneal
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26. Yamashita K, Komohara Y, Uchihara T, Arima K, Uemura S, Hanada N, Baba H. A
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27. Matsumura K, Yamamura K, Miyamoto H, Hara Y, Oda E, Akahoshi S, Yoshida K,
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Colorectal Liver Metastases Successfully Treated With Fluorouracil Plus Leucovorin
Monotherapy and Microwave Ablation. Anticancer Res. 42:1645-1651, 2022
28. Arima K, Komohara Y, Uchihara T, Yamashita K, Uemura S, Hanada N, Baba H. A
Case of Mesenteric Desmoid Tumor Causing Bowel Obstruction After Laparoscopic
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6）細胞医学分野
1.

Igata T, Tanaka H, Etoh K, Hong S, Tani N, Koga T, Nakao M: Loss of thetranscription repressor ZHX3 induces senescence-associated gene expression andmitochondrial-nucleolar activation. PLoS One 17: e0262488, 2022

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Matsumori H, Watanabe K, Tachiwana H, Fujita T, Ito Y, Tokunaga M, SakataSogawa K, Osakada H, Haraguchi T, Awatsu A, Ochiai H, Sakata Y, Ochiai K, Toki
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Thamrongwaranggoon U, Detarya M, Seubwai W, Saengboonee C, Hino S, Koga T,
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Hino Y, Nagaoka K, Oki S, Etoh K, Hino S, Nakao M: Mitochondrial stress induces
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Thamrongwaranggoon U, Kuribayashi K, Araki H, Hino Y, Koga T, Seubwai W,
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Araki H, Hino S, Anan K, Kuribayashi K, Etoh K, Seko D, Takase R, Kohrogi K,
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7）心臓発生研究室
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Yuge Y, Nishiyama K, Arima Y, Hanada Y, Oguri-Nakamura E, Hanada S, Ishii T,
Wakayama T, Hasegawa U, Tsujita K, Yokokawa R, Miura T, Itoh T, Tsujita K,
Mochizuki N & Fukuhara S: Mechanical loading of intraluminal pressure mediates
wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nature
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Nishiyama C, Saito Y, Sakaguchi A, Kaneko M, Kiyonari H, Xu Y, Arima Y, Uosaki
H, Kimura W: Prolonged Myocardial Regenerative Capacity in Neonatal Opossum.
Circulation 146: 125-139, 2022

〇がん・幹細胞研究部門
8）消化器外科学講座
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Miyoshi J, Zhu Z, Luo A, Toden S, Zhou X, Izumi D, Kanda M, Takayama T, Parker
IM, Wang M, Gao F, Zaidi AH, Baba H, Kodera Y, Cui Y, Wang X, Liu Z, Goel A: A
microRNA-based liquid biopsy signature for the early detection of esophageal
squamous cell carcinoma: a retrospective, prospective and multicenter study. Mol
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2.

Roy S, Kanda M, Nomura S, Zhu Z, Toiyama Y, Taketomi A, Goldenring J, Baba H,
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3.

Arima K, Zhong R, Ugai T, Zhao M, Haruki K, Akimoto N, Lau MC, Okadome K,
Mehta RS, Vayrynen JP, Kishikawa J, Twombly TS, Shi S, Fujiyoshi K, Kosumi K,
Ogata Y, Baba H, Wang F, Wu K, Song M, Zhang X, Fuchs CS, Sears CL, Willett

WC, Giovannucci EL, Meyerhardt JA, Garrett WS, Huttenhower C, Chan AT, Nowak
JA, Giannakis M, Ogino S: Western-style diet, pks island-carrying Escherichia coli,
and colorectal cancer: Analyses from two large prospective cohort studies.
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Qian T, Fujiwara N, Koneru B, Ono A, Kubota N, Jajoriya AK, Tung MG, Crouchet
E, Song WM, Marquez CA, Panda G, Hoshida A, Raman I, Li QZ, Lewis C, Yopp A,
Rich NE, Singal AG, Nakagawa S, Goossens N, Higashi T, Koh AP, Bian CB,
Hoshida H, Tabrizian P, Gunasekaran G, Florman S, Schwarz ME, Hiotis SP,
Nakahara T, Aikata H, Murakami E, Beppu T, Baba H, Rew W, Bhatia S, Kobayashi
M, Kumada H, Fobar AJ, Parikh ND, Marrero JA, Rwema SH, Nair V, Patel M, KimSchulze S, Corey K, O'Leary JG, Klintmalm GB, Thomas DL, Dibas M, Rodriguez
G, Zhang B, Friedman SL, Baumert TF, Fuchs BC, Chayama K, Zhu S, Chung RT,
Hoshida Y: Molecular signature predictive of long-term liver fibrosis progression to
inform antifibrotic drug development. Gastroenterology 162:1210-1225, 2022

5.

Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G,
Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz
ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri
M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K,
Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H,
Chayama K, Baumert TF, Hoshida Y: Molecular signatures of long-term
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Bertsimas D, Margonis GA, Sujichantararat S, Boerner T, Ma Y, Wang J, Kamphues
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Poultsides G, Seeliger H, Beyer K, Kaczirek K, Kornprat P, Aucejo FN, de Santibanes
E, Baba H, Endo I, Lonning PE, Kreis ME, Weiss MJ, Wolfgang CL, D'Angelica M:
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Okuno K, Tokunaga M, Kinugasa Y, Baba H, Kodera Y, Goel A: A transcriptomic
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Yoshida N, Eto K, Kurashige J, Izumi D, Sawayama H, Horinouchi T, Iwatsuki M,
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in patients with esophageal squamous cell carcinoma undergoing esophagectomy.
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Sezaki M, Hayashi Y, Nakato G, Wang Y, Nakata S, Biswas S, Morishima T,
Fakruddin M, Moon J, Ahn S, Kim P, Miyamoto Y, Baba H, Fukuda S, Takizawa H:
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10. Olthof PB, Buettner S, Andreatos N, Wang J, Loes IM, Wagner D, Sasaki K, MacherBeer A, Kamphues C, Pozios I, Seeliger H, Morioka D, Imai K, Kaczirek K, Pawlik
TM, Poultsides G, Burkhart R, Endo I, Baba H, Kornprat P, Aucejo FN, Lonning PE,
Beyer K, Weiss MJ, Wolfgang CL, Kreis ME, Margonis GA: KRAS alterations incolorectal liver metastases: shifting to exon, codon, and point mutations. Br J Surg
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11. Liu Y, Baba Y, Ishimoto T, Gu X, Zhang J, Nomoto D, Okadome K, Baba H, Qiu P:
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12. Kobayshi K, Suyama K, Katsuya H, Izawa N, Uenosono Y, Hu Q, Kusumoto T, Otsu
H, Orita H, Kawanaka H, Shibao K, Koga S, Shimokawa M, Makiyama A, Saeki H,
Oki E, Baba H, Mori M, group Ks: A phase II multicenter trial assessing the efficacy
and safety of first-line S-1 + ramucirumab in elderly patients with advanced/recurrent
gastric cancer: KSCC1701. Eur J Cancer 166:279-286, 2022
13. Wada Y, Shimada M, Morine Y, Ikemoto T, Saito Y, Baba H, Mori M, Goel A: A
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14. Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome K, Harada K, Ishimoto T, Iwatsuki
M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Moroishi T, Komohara Y,
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15. Yamane T, Kanamori Y, Sawayama H, Yano H, Nita A, Ohta Y, Hinokuma H, Maeda
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16. Lan C, Kitano Y, Yamashita YI, Yamao T, Kajiyama K, Yoshizumi T, Fukuzawa K,
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lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma. Br J
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17. Wada Y, Shimada M, Morine Y, Ikemoto T, Saito Y, Baba H, Mori M, Goel A: A
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18. Horiguchi H, Kadomatsu T, Yumoto S, Masuda T, Miyata K, Yamamura S, Sato M,
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19. Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara
T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani
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20. Iwatsuki M, Orita H, Kobayashi K, Hidaka S, Arigami T, Kusumoto T, Satake H, Oki
E, Tsutsumi S, Tobimatsu K, Shimokawa M, Saeki H, Makiyama A, Baba H, Mori
M: Phase II study of S-1 and oxaliplatin as neoadjuvant chemotherapy for locallyadvanced adenocarcinoma of the gastric or esophagogastric junction: KSCC1601.
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21. Matsumoto C, Iwatsuki M, Iwagami S, Morinaga T, Yamashita K, Nakamura K, Eto
K, Kurashige J, Baba Y, Miyamoto Y, Yoshida N, Komohara Y, Baba H: Prophylactic
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22. Yamaguchi K, Boku N, Muro K, Yoshida K, Baba H, Tanaka S, Akamatsu A, Sano
T: Real-world safety and effectiveness of nivolumab in Japanese patients withunresectable advanced or recurrent gastric/gastroesophageal junction cancer that has
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23. Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S,
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Hu X, Wei F, Arima Y, Moroishi T, Nishiyama K, Sheng G, Mukunoki T, Otani J,
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24. Okadome K, Baba Y, Yasuda-Yoshihara N, Nomoto D, Yagi T, Toihata T, Ogawa K,
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25. Yusa T, Yamashita YI, Okabe H, Nakao Y, Itoyama R, Kitano Y, Kaida T, Miyata T,
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26. Shimizu D, Taniue K, Matsui Y, Haeno H, Araki H, Miura F, Fukunaga M, Shiraishi
K, Miyamoto Y, Tsukamoto S, Komine A, Kobayashi Y, Kitagawa A, Yoshikawa Y,
Sato K, Saito T, Ito S, Masuda T, Niida A, Suzuki M, Baba H, Ito T, Akimitsu N,
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27. Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H,
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28. Eto K, Yoshida N, Iwatsuki M, Iwagami S, Nakamura K, Morita K, Ikeshima S,
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29. Horino T, Tokunaga R, Miyamoto Y, Hiyoshi Y, Akiyama T, Daitoku N, Sakamoto Y,
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independent prognosticator in colorectal cancer patients after curative resection. Ann
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30. Miyata T, Yamashita YI, Arima K, Higashi T, Hayashi H, Imai K, Nitta H, Chikamoto
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31. Ogawa K, Miyamoto Y, Harada K, Eto K, Sawayama H, Iwagami S, Iwatsuki M,
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Gastroenterol Surg 6:523-530, 2022
32. Sawayama H, Miyamoto Y, Yoshida N, Baba H: Essential updates 2020/2021:
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33. Yamamura K, Yamashita YI, Yamao T, Kitano Y, Arima K, Miyata T, Higashi T,
Hayashi H, Beppu T, Baba H: Clinical impact of atrophic changes in remnant
pancreas on the development of nonalcoholic fatty liver disease afterpancreaticoduodenectomy. Ann Gastroenterol Surg 6:555-561, 2022
34. Yoshida K, Yasufuku I, Terashima M, Young Rha S, Moon Bae J, Li G, Katai H,
Watanabe M, Seto Y, Hoon Noh S, Kwang Yang H, Ji J, Baba H, Kitagawa Y, Morita
S, Nishiyama M, Kodera Y, Convo-Gc-1 Study Group FoACO: International
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35. Nomoto D, Baba Y, Okadome K, Yagi T, Kalikawe R, Kiyozumi Y, Harada K, Eto K,
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2022
36. Matsumura K, Hayashi H, Uemura N, Ogata Y, Zhao L, Sato H, Shiraishi Y, Kuroki
H, Kitamura F, Kaida T, Higashi T, Nakagawa S, Mima K, Imai K, Yamashita YI,
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37. Sadahiro S, Sakamoto K, Tsuchiya T, Takahashi T, Ohge H, Sato T, Kondo K, Ogata
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38. Kawata A, Imai K, Tamura Y, Kaida T, Mima K, Nakagawa S, Hayashi H, Yamashita
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39. Horino T, Tokunaga R, Baba H: Collateral circulation from inferior mesenteric artery.
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40. Ono S, Adachi T, Ohtsuka T, Kimura R, Nishihara K, Watanabe Y, Nagano H,
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41. Sasaki K, Margonis GA, Moro A, Wang J, Wagner D, Gagniere J, Shin JK, D'Silva
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42. Lan C, Yamashita YI, Hayashi H, Nakagawa S, Imai K, Mima K, Kaida T, Matsumoto
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43. Miyata T, Hayashi H, Baba H: ASO author reflections: Is histologic liver
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44. Miyata T, Hayashi H, Yamashita YI, Matsumura K, Higashi T, Imai K, Nitta H,
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45. Morinaga T, Iwatsuki M, Yamashita K, Matsumoto C, Harada K, Kurashige J,
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46. Yoshida N, Eto K, Baba H: ASO author reflections: Development of useful predictive
markers for postoperative morbidity aiming to improve short-term and long-term
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47. Yoshida N, Eto K, Baba H: ASO authorreflections: Insufficient preoperative smoking
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48. Yoshida N, Eto K, Horinouchi T, Harada K, Sawayama H, Ogawa K, Nagai Y,
Iwatsuki M, Iwagami S, Ishimoto T, Baba Y, Miyamoto Y, Baba H: Preoperativesmoking cessation and prognosis after curative esophagectomy for esophageal
cancer: A cross-sectional study. Ann Surg Oncol 29:8172-8180, 2022
49. Yoshida N, Horinouchi T, Toihata T, Harada K, Eto K, Sawayama H, Iwatsuki M,
Nagai Y, Ishimoto T, Baba Y, Miyamoto Y, Baba H: Clinical significance ofpretreatment red blood cell distribution width as a predictive marker for postoperative
morbidity after esophagectomy for esophageal cancer: A retrospective study. Ann
Surg Oncol 29:606-613, 2022
50. Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H,
Ishimoto T, Baba Y, Yoshida N, Baba H: Activin A promotes cell proliferation,
invasion and migration and predicts poor prognosis in patients with colorectal cancer.
Oncol Rep 47, 2022

51. Harada K, Yamashita K, Iwatsuki M, Baba H, Ajani JA: Intraperitoneal therapy for
gastric cancer peritoneal carcinomatosis. Expert Rev Clin Pharmacol 15:43-49, 2022
52. Nakamura K, Eto K, Iwagami S, Ogawa K, Sawayama H, Ishimoto T, Iwatsuki M,
Baba Y, Miyamoto Y, Yoshida N, Baba H: Clinicopathological characteristics andprognosis of poorly cohesive cell subtype of gastric cancer. Int J Clin Oncol 27:512519, 2022
53. Yamane T, Sawayama H, Yoshida N, Morinaga T, Akiyama T, Eto K, Harada K,
Ogawa K, Iwatsuki M, Iwagami S, Baba Y, Miyamoto Y, Baba H: Preoperativetransferrin level is a novel indicator of short- and long-term outcomes after
esophageal cancer surgery. Int J Clin Oncol 27:131-140, 2022
54. Kitano Y, Pietrasz D, Fernandez-Sevilla E, Golse N, Vibert E, Sa Cunha A, Azoulay
D, Cherqui D, Baba H, Adam R, Allard MA: Subjective difficulty scale in livertransplantation: A prospective observational study. Transpl Int 35:10308, 2022
55. Kojima T, Hara H, Tsuji A, Yasui H, Muro K, Satoh T, Ogata T, Ishihara R, Goto M,
Baba H, Nishina T, Han S, Sakata T, Yatsuzuka N, Doi T, Kato K: First-line
pembrolizumab + chemotherapy in Japanese patients with advanced/metastatic
esophageal cancer from KEYNOTE-590. Esophagus 19:683-692, 2022
56. Murakami K, Yoshida N, Taniyama Y, Takahashi K, Toyozumi T, Uno T, Kamei T,
Baba H, Matsubara H: Maximum standardized uptake value change rate before andafter neoadjuvant chemotherapy can predict early recurrence in patients with locallyadvanced esophageal cancer: a multi-institutional cohort study of 220 patients inJapan. Esophagus 19:205-213, 2022
57. Kumamoto S, Fukuyama S, Nagano S, Yasuda K, Kitamura Y, Iwatsuki M, Baba H,
Ihara T, Nakanishi Y, Nakashima Y: Fabrication of Three-Dimensionally Deformable
Metal Structures Using Precision Electroforming. Micromachines 13, 2022

58. Morito A, Kosumi K, Kubota T, Yumoto S, Matsumoto T, Mima K, Inoue M,
Mizumoto T, Miyanari N, Baba H: Investigation of risk factors for postoperative
seroma/hematoma after TAPP. Surg Endosc 36:4741-4747, 2022
59. Uemura N, Hayashi H, Baba H: Statin as a therapeutic agent in gastroenterologicalcancer. World J Gastrointest Oncol 14:110-123, 2022
60. Eto K, Yoshida N, Iwatsuki M, Iwagami S, Yamashita K, Nakamura K, Harada K,
Sawayama H, Ishimoto T, Baba Y, Miyamoto Y, Baba H: Impact of type ofgastrectomy on death from pneumonia in elderly patients with gastric cancer over thelong term. World J Surg 46:425-432, 2022
61. Imai K, Miyamoto Y, Tamura Y, Hayashi H, Ikeda O, Yamashita YI, Baba H:
Simultaneous portal vein embolization and colorectal resection in a hybridinterventional radiology/operating suite for synchronous colorectal liver metastases.
J Gastrointest Surg 26:1307-1310, 2022
62. Kitano Y, Yamashita YI, Matsumoto T, Kinoshita S, Itoyama R, Kaida T, Hayashi H,
Imai K, Chikamoto A, Baba H: Survival impact of perioperative red blood celltransfusion

duringpancreatectomyinpatients

withpancreatic

ductaladenocarcinoma: A propensity score matching analysis. Pancreas 51:200-204, 2022
63. Kitano Y, Hayashi H, Matsumoto T, Nakao Y, Kaida T, Mima K, Imai K, Yamashita
YI, Baba H: The efficacy of anatomic resection for hepatocellular carcinoma within
Milan criteria: A retrospective single-institution case-matched study. Eur J Surg
Oncol 48:2008-2013, 2022
64. Amini N, Andreatos N, Margonis GA, Buettner S, Wang J, Galjart B, Wagner D,
Sasaki K, Angelou A, Sun J, Kamphues C, Beer A, Morioka D, Loes IM, Antoniou
E, Imai K, Pikoulis E, He J, Kaczirek K, Poultsides G, Verhoef C, Lonning PE, Endo
I, Baba H, Kornprat P, F NA, Kreis ME, Christopher WL, Weiss MJ, Safar B,
Burkhart RA: Mutant KRAS as a prognostic biomarker after hepatectomy for rectal
cancer metastases: Does the primary disease site matter? J Hepatobiliary Pancreat

Sci 29:417-427, 2022
65. Homma Y, Endo I, Matsuyama R, Sho M, Mizuno S, Seyama Y, Hirano S, Aono T,
Kitami C, Morita Y, Takeda Y, Yoshida K, Tani M, Kaiho T, Yamamoto Y, Aoki H,
Ogawa M, Niguma T, Mataki Y, Kawasaki H, Baba H, Yokomizo H, Rikiyama T,
Yamaue H, Yamamoto M: Outcomes of lung metastasis from pancreatic cancer: A
nationwide multicenter analysis. J Hepatobiliary Pancreat Sci 29:552-561, 2022
66. Satoi S, Takahara N, Fujii T, Isayama H, Yamada S, Tsuji Y, Miyato H, Yamaguchi
H, Yamamoto T, Hashimoto D, Yamaki S, Nakai Y, Saito K, Baba H, Watanabe T,
Ishii S, Hayashi M, Kurimoto K, Shimada H, Kitayama J: Synopsis of a clinicalpractice guideline for pancreatic ductal adenocarcinoma with peritoneal
dissemination in Japan; Japan Peritoneal Malignancy Study Group. J Hepatobiliary
Pancreat Sci 29:600-608, 2022
67. Horinouchi T, Yoshida N, Harada K, Eto K, Sawayama H, Iwatsuki M, Iwagami S,
Baba Y, Miyamoto Y, Baba H: A retrospective study of preoperative malnutrition
based on the Controlling Nutritional Status score as an associated marker for shortterm outcomes after open and minimally invasive esophagectomy for esophageal
cancer. Langenbecks Arch Surg 407:3367-3375, 2022
68. Matsumura M, Hasegawa K, Oba M, Yamaguchi K, Uetake H, Yoshino T, Morita S,
Takahashi K, Unno M, Shimada Y, Muro K, Matsuhashi N, Mori M, Baba H,
Shimada M, Mise Y, Kawaguchi Y, Kagimura T, Ishigure K, Saiura A, Sugihara K,
Kokudo N: A randomized controlled trial of surgery and postoperative modified
FOLFOX6 versus surgery and perioperative modified FOLFOX6 plus cetuximab inpatients with KRAS wild-type resectable colorectal liver metastases: EXPERT study.
Langenbecks Arch Surg 407:1345-1356, 2022
69. Miyata T, Matsumoto T, Nakao Y, Higashi T, Imai K, Hayashi H, Nitta H, Chikamoto
A, Beppu T, Yamashita YI, Baba H: Major postoperative complications are associatedwith early recurrence of hepatocellular carcinoma following hepatectomy.
Langenbecks Arch Surg 407:2373-2380, 2022

70. Yamane T, Yoshida N, Horinouchi T, Morinaga T, Eto K, Harada K, Ogawa K,
Sawayama H, Iwatsuki M, Baba Y, Miyamoto Y, Baba H: Minimally invasive
esophagectomy may contribute to low incidence of postoperative surgical site
infection in patients with poor glycemic control. Langenbecks Arch Surg 407:579585, 2022
71. Adachi Y, Tokunaga R, Matsumoto K, Nakao Y, Itoyama R, Kuramoto K, Karashima
R, Nitta H, Tomiyasu S, Baba H, Takamori H: What are the factors predictive of
postoperative complications in patients with colorectal cancer undergoing stenting asa bridge to surgery? J Surg Oncol 125:982-990, 2022
72. Mima K, Imai K, Kaida T, Matsumoto T, Nakagawa S, Sawayama H, Hayashi H,
Yamashita YI, Baba H: Impairment of perioperative activities of daily living is
associated with poor prognosis following hepatectomy for hepatocellular carcinoma.
J Surg Oncol 126:995-1002, 2022
73. Hara Y, Baba Y, Toihata T, Harada K, Ogawa K, Iwatsuki M, Iwagami S, Miyamoto
Y, Yoshida N, Baba H: Immune-related adverse events and prognosis in patients withupper gastrointestinal cancer treated with nivolumab. J Gastrointest Oncol 13:27792788, 2022
74. Masuda T, Takamori H, Ogawa K, Shimizu K, Karashima R, Nitta H, Matsumoto K,
Okino T, Baba H: C-reactive protein level on postoperative day 3 as a predictor ofanastomotic leakage after elective right-sided colectomy. Surg Today 52:337-343,
2022
75. Matsumoto T, Kitano Y, Imai K, Kinoshita S, Sato H, Shiraishi Y, Mima K, Hayashi
H, Yamashita YI, Baba H: Clinical significance of preoperative inflammation-based
score for the prognosis of patients with hepatocellular carcinoma who underwent
hepatectomy. Surg Today 52:1008-1015, 2022
76. Yamashita YI, Yamao T, Nakao Y, Miyata T, Ikegami Y, Yamane S, Ito T, Furukawa

T, Cho J, Wu F, Fujie Y, Arima M, Aishima S, Ijima H, Baba H: Efficacy of a newly
developed bioabsorbable pancreatic clip for distal pancreatectomy in swine. Surg
Today 52:1109-1114, 2022
77. Arima K, Komohara Y, Uchihara T, Yamashita K, Uemura S, Hanada N, Baba H: A
case of mesenteric desmoid tumor causing bowel obstruction after laparoscopic
surgery. Anticancer Res 42:381-384, 2022
78. Yusa T, Yamashita YI, Nitta H, Nakao Y, Itoyama R, Kitano Y, Kaida T, Miyata T,
Mima K, Imai K, Hayashi H, Baba H: Efficacy of ring drape and unused sterile
instruments for incisional SSI after hepatectomy. Anticancer Res 42:1007-1012,
2022
79. Mitsuura C, Miyamoto Y, Ogawa K, Sawayama H, Toihata T, Harada K, Eto K,
Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Baba H: Successful management of analsquamous cell carcinoma with liver and ovary metastases: A case report. In Vivo
36:3023-3028, 2022
80. Uchihara T, Komohara Y, Yamashita K, Arima K, Uemura S, Hanada N, Baba H:
Chronic appendicitis caused by a perforating fish bone: Case report and brief
literature review. In Vivo 36:1982-1985, 2022
81. Baba Y, Nakagawa S, Toihata T, Harada K, Iwatsuki M, Hayashi H, Miyamoto Y,
Yoshida N, Baba H: Pan-immune-inflammation value and prognosis in patients withesophageal cancer. Annals of Surgery Open 3:e113, 2022
82. Yoshida N, Horinouchi T, Eto K, Harada K, Sawayama H, Imamura Y, Iwatsuki M,
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underwent esophagectomy: A retrospective study. Annals of Surgery Open 3, 2022
83. Yoshida N, Sasaki K, Kanetaka K, Kimura Y, Shibata T, Ikenoue M, Nakashima Y,
Sadanaga N, Eto K, Tsuruda Y, Kobayashi S, Nakanoko T, Suzuki K, Takeno S,

Yamamoto M, Morita M, Toh Y, Baba H: High pretreatment mean corpuscularvolume can predict worse prognosis in patients with esophageal squamous cell
carcinoma who have undergone curative esophagectomy. Annals of Surgery Open3:e165, 2022
84. Yamashita K, Komohara Y, Uchihara T, Arima K, Uemura S, Hanada N, Baba H: A
rare case of perforation of a colorectal tumor by a fish bone. Clin J Gastroenterol
15:598-602, 2022
85. Yumoto S, Doi K, Higashi T, Shimao Y, Ueda M, Ishihara A, Adachi Y, Ishiodori H,
Honda S, Baba H: Intra-abdominal bleeding caused by amyloid transthyretin
amyloidosis in the gastrointestinal tract: a case report. Clin J Gastroenterol 15:140145, 2022
86. Yumoto S, Nakagawa S, Hayashi H, Ogawa D, Shiraishi Y, Sato H, Matsumoto T,
Imai K, Yamashita YI, Baba H: Multimodal therapy with aggressive hepatectomy,
everolimus, and octreotide for metastatic pancreatic neuroendocrine neoplasm
enables 10-year survival. Clin J Gastroenterol 15:1136-1144, 2022
87. Maeda Y, Miyamoto Y, Hiyoshi Y, Eto K, Iwatsuki M, Iwagami S, Baba Y, Yoshida
N, Baba H: Surgical removal of giant pelvic liposarcoma after preoperativetranscatheter arterial embolization. Int Cancer Conf J 11:275-279, 2022
88. Masuda T, Takamori H, Kato M, Mitsuura C, Shiraishi Y, Itoyama R, Shimizu K,
Karashima R, Nitta H, Baba H: Safety assessment of dextrin hydrogel adhesion
barrier (AdSpray®) for elective laparoscopic cholecystectomy. Laparoscopic,
Endoscopic and Robotic Surgery 5:61-65, 2022
89. Hara Y, Nakamura K, Iwagami S, Ogawa K, Sawayama H, Iwatsuki M, Baba Y,
Miyamoto Y, Yoshida N, Baba H: A case of clinical stage I gastric cancer with aschwannoma on the left supraclavicular fossa suspected as Virchow's node metastasis.
Surg Case Rep 8:95, 2022

90. Horino T, Miyata T, Inoue M, Ono K, Ono A, Tagayasu Y, Nomoto D, Mizumoto T,
Kubota T, Miyanari N, Baba H: Shanghai fever, a fatal enteric illness, in an adultpatient with neutropenia caused by treatment-related myelodysplastic syndrome: acase report. Surg Case Rep 8:69, 2022
91. Sawayama H, Miyamoto Y, Ogawa K, Ohuchi M, Hisano Y, Kato M, Tubakihara H,
Yoshida N, Baba H: Pathologic complete response after laparoscopic surgery
following treatment with nivolumab and ipilimumab for anticancer drug-resistant
MSI-high descending colon cancer: a case report and literature review. Surg Case
Rep 8:223, 2022
92. Tagayasu Y, Miyamoto Y, Sawayama H, Ogawa K, Kato R, Yoshida N, Mukasa A,
Baba H: Rectal cancer diagnosed after resection of isolated brain metastasis. Surg
Case Rep 8:52, 2022
93. Nakao Y, Hayashi H, Yamashita YI, Takashi O, Matsumura K, Uemura N, Kitamura
F, Itoyama R, Yusa T, Taki K, Miyata T, Higashi T, Nakagawa S, Okabe H, Imai K,
Baba H: Risk factors for lymph node metastasis in patients with pancreatic
neuroendocrine neoplasms. World J Clin Oncol 13:520-528, 2022
94. Kosumi K, Mima K, Kanemitsu K, Tajiri T, Takematsu T, Sakamoto Y, Inoue M,
Miyamoto Y, Mizumoto T, Kubota T, Miyanari N, Baba H: Self-expanding metal
stent placement and pathological alterations among obstructive colorectal cancer
cases. World J Gastrointest Endosc 14:704-717, 2022
95. Kaida T, Hayashi H, Sato H, Kinoshita S, Matsumoto T, Shiraishi Y, Kitano Y,
Higashi T, Imai K, Yamashita YI, Baba H: Assessment for the minimal invasivenessof laparoscopic liver resection by interleukin-6 and thrombospondin-1. World J
Hepatol 14:234-243, 2022
96. Miyamoto Y, Ogawa K, Ohuchi M, Tokunaga R, Baba H: Emerging evidence of
immunotherapy for colorectal cancer. Ann Gastroenterol Surg, 2022 Nov 08. doi:
10.1002/ags3.12633. Online ahead of print.

97. Miyamoto Y, Akiyama T, Kato R, Sawayama H, Ogawa K, Yoshida N, Baba H:
Prognostic significance of systemic inflammation indices by KRAS Status in patientswith metastatic colorectal cancer. Dis Colon Rectum, 2022 Feb 21. doi:
10.1097/DCR.0000000000002392. Online ahead of print.
98. Wei F, Uchihara T, Yonemura A, Yasuda-Yoshihara N, Yasuda T, Semba T, Fukuda
M, Akiyama T, Kitamura F, Bu L, Hu X, Fu L, Zhang J, Kariya R, Yamasaki J, Aihara
K, Yamashita K, Nagano O, Okada S, Baba H, Ishimoto T: A novel tdTomatotransgenic mouse model to visualize FAP-positive cancer-associated fibroblasts.
FEBS J, 2022 Dec 24. doi: 10.1111/febs.16712. Online ahead of print.
99. Hirao H, Okabe H, Masuda T, Ogawa D, Uemura N, Kuroda D, Taki K, Tomiyasu S,
Hirota M, Hibi T, Baba H, Sugita H: Intestinal fluid CT level could predict
pathological small bowel ischemia in small bowel obstruction. Indian J Surg, 2022
Aug 02.

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100.Zhao Y, Peng F, Wang C, Murano T, Baba H, Ikematsu H, Li W, Goel A: A DNA
methylation-based epigenetic signature for the identification of lymph nodemetastasis in T1 colorectal cancer. Ann Surg 277:655-663, 2023
101.Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A,
Semba T, Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F,
Yamashita K, Eto K, Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O,
Satou Y, Saya H, Tan P, Baba H, Ishimoto T: Stromal reprogramming through dual
PDGFRalpha/beta blockade boosts the efficacy of anti-PD-1 immunotherapy infibrotic tumors. Cancer Res 83:753-770, 2023
102.Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T,
Higashi T, Nakagawa S, Mima K, Imai K, Baba H: Hyperglycaemia induces
metabolic reprogramming into a glycolytic phenotype and promotes epithelialmesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreaticcancer. Br J Cancer 128:844-856, 2023

103.Kosumi K, Baba Y, Yamamura K, Nomoto D, Okadome K, Yagi T, Toihata T,
Kiyozumi Y, Harada K, Eto K, Sawayama H, Ishimoto T, Iwatsuki M, Iwagami S,
Miyamoto Y, Yoshida N, Watanabe M, Baba H: Intratumour Fusobacterium
nucleatum and immune response to oesophageal cancer. Br J Cancer 128:1155-1165,
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104.Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T,
Kitamura F, Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K,
Iwagami S, Yashiro M, Komohara Y, Baba H, Ishimoto T: IL-1beta derived frommixed-polarized macrophages activates fibroblasts and synergistically forms acancer-promoting microenvironment. Gastric Cancer 26:187-202, 2023
105.Liu Z, Hayashi H, Matsumura K, Uemura N, Shiraishi Y, Sato H, Baba H: Biologicaland clinical impacts of glucose metabolism in pancreatic ductal adenocarcinoma.
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106.Yoshida N, Eto K, Matsumoto T, Kosumi K, Imamura Y, Iwatsuki M, Baba Y,
Miyamoto Y, Watanabe M, Baba H: Omental flap wrapping around theesophagogastricanastomosis

andassociation

withanastomotic

leak

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esophagectomy for esophageal cancer: A propensity score-matching analysis. J Am
Coll Surg 236:189-197, 2023
107.Yasuda T, Baba H, Ishimoto T: Cellular senescence in the tumor microenvironmentand context-specific cancer treatment strategies. FEBS J 290:1290-1302, 2023
108.Mima K, Nakagawa S, Miyata T, Yamashita YI, Baba H: Frailty and surgicaloutcomes in gastrointestinal cancer: Integration of geriatric assessment andprehabilitation into surgical practice for vulnerable patients. Ann Gastroenterol Surg
7:27-41, 2023
109.Mima K, Hayashi H, Yumoto S, Matsumoto T, Tsukamoto M, Miyata T, Nakagawa
S, Nitta H, Baba H: Disability in perioperative activities of daily living is associatedwith worse survival outcomes following hepatic resection in patients withintrahepatic cholangiocarcinoma. Hepatol Res 53:135-144, 2023
110.Harada K, Matsumoto C, Toihata T, Kosumi K, Iwatsuki M, Baba Y, Ohuchi M, Eto
K, Ogawa K, Sawayama H, Iwagami S, Miyamoto Y, Yoshida N, Baba H: C-Reactive
protein levels after esophagectomy are associated with increased surgicalcomplications and poor prognosis in esophageal squamous cell carcinoma patients.
Ann Surg Oncol 30:1554-1563, 2023
111.Ikenaga N, Miyasaka Y, Ohtsuka T, Nakata K, Adachi T, Eguchi S, Nishihara K,
Inomata M, Kurahara H, Hisaka T, Baba H, Nagano H, Ueki T, Noshiro H, Tokunaga
S, Ishigami K, Nakamura M, Kyushu Study Group of Treatment for Pancreatobiliary
C: A prospective multicenter phase II trial of neoadjuvant chemotherapy withgemcitabine plus nab-paclitaxel for borderline resectable pancreatic cancer witharterial involvement. Ann Surg Oncol 30:193-202, 2023
112.Morinaga T, Iwatsuki M, Yamashita K, Yasuda-Yoshihara N, Yamane T, Matsumoto
C, Harada K, Eto K, Kurashige J, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Baba
H: Dynamic alteration in HLA-E expression and soluble HLA-E via Interaction withnatural killer cells in gastric cancer. Ann Surg Oncol 30:1240-1252, 2023
113.Shindo Y, Nagano H, Kanai M, Kobayashi S, Wada H, Sakai D, Eguchi H, Baba H,
Kamachi H, Takayama T, Ueno M, Takahashi M, Nakagami Y, Yoshimura K, Hatano
E, Ioka T: Clinical outcomes of second‑line chemotherapy after gemcitabine andcisplatin plus S‑1 treatment for patients with advanced biliary tract cancer in the
KHBO1401‑3A study. Oncol Rep 49(2):41, 2023
114.Horino T, Tokunaga R, Miyamoto Y, Hiyoshi Y, Akiyama T, Daitoku N, Sakamoto Y,
Yoshida N, Baba H: The impact of the advanced lung cancer inflammation index on
the outcomes of patients with metastatic colorectal cancer who receive chemotherapy.
Int J Clin Oncol 28:400-408, 2023
115.Horinouchi T, Yoshida N, Toihata T, Harada K, Eto K, Ogawa K, Sawayama H,

Iwatsuki M, Baba Y, Miyamoto Y, Baba H: Postoperative respiratory morbidity canadversely affect prognosis in thoracoscopic esophagectomy for esophageal cancer: aretrospective study. Surg Endosc 37:2104-2111, 2023
116.Ioka T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A,
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Shimizu J, Goto T, Shindo Y, Yoshimura K, Hatano E, Nagano H, Kansai
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plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401MITSUBA). J Hepatobiliary Pancreat Sci 30:102-110, 2023
117.Kanaka S, Matsuda A, Yamada T, Miyamoto Y, Yokoyama Y, Matsumoto S, Sonoda
H, Ohta R, Shinji S, Sekiguchi K, Baba H, Yoshida H: Segmental or right hemicolectomy? The optimal surgical procedure for transverse colon cancer: a propensity
score-matched, multicenter, retrospective study. Int J Colorectal Dis 38:58, 2023
118.Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T,
Kubota T, Yanagida E, Murayama T, Miyanari N, Baba H: Conversion surgery after
atezolizumab plus bevacizumab for primary and peritoneal metastasis after
hepatocellular carcinoma rupture. Anticancer Res 43:943-947, 2023
119.Tubakihara H, Sawayama H, Komohara Y, Miyamoto Y, Ogawa K, Ohuchi M,
Yoshida N, Baba H: A case of familial adenomatous polyposis with protein-losing
enteropathy treated by laparoscopic total colorectal resection: A literature review.
Asian J Endosc Surg 16:77-81, 2023
120.Stachler MD, Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe
M, Agoston A, Jajoo K, Davison JM, Nason K, Getz G, Wang KK, Imamura Y, Odze
R, Bass AJ, Zhang C-Z: Origins of cancer genome complexity revealed by haplotyperesolved genomic analysis of evolution of Barrett’s esophagus to esophageal
adenocarcinoma. bioRxiv:2021.2003.2026.437288, 2023
121.Ichida A, Kokudo T, Shimada S, Hatano E, Kubo S, Kato Y, Ishikawa Y, Mori A,

Baba H, Matsuyama Y, Endo I, Yamaue H, Yamamoto M, Kokudo N, Hasegawa K:
Liver resection for hepatocellular carcinoma with tumor thrombus in the inferior vena
cava or right atrium: A large-scale multicenter survey conducted in Japan. Ann Surg,
2023 Jan 2. doi: 10.1097/SLA.0000000000005789. Online ahead of print.
122.Saito Y, Fujiwara Y, Miyamoto Y, Ohnishi K, Nakashima Y, Tabata Y, Baba H,
Komohara Y: CD169(+) sinus macrophages in regional lymph nodes do not predictmismatch-repair status of patients with colorectal cancer. Cancer Med, 2023 Feb 27.
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123.Morito A, Harada K, Iwatsuki M, Maeda Y, Mitsuura C, Toihata T, Kosumi K, Eto K,
Iwagami S, Baba Y, Miyamoto Y, Yoshida N, Baba H: Frailty assessed by the clinicalfrailty scale is associated with prognosis after esophagectomy. Ann Surg Oncol, 2023
Mar 7. doi: 10.1245/s10434-023-13313-w. Online ahead of print.
124.Maehara Y, Oki E, Ota M, Harimoto N, Ando K, Nakanishi R, Kawazoe T, Fujimoto
Y, Nonaka K, Kitao H, Iimori M, Makino K, Takechi T, Sagara T, Miyadera K,
Matsuoka K, Tsukihara H, Kataoka Y, Wakasa T, Ochiiwa H, Kamahori Y, Tokunaga
E, Saeki H, Yoshizumi T, Kakeji Y, Shirabe K, Baba H, Shimada M: Lineage of drug
discovery research on fluorinated pyrimidines: chronicle of the achievements
accomplished by Professor Setsuro Fujii. Int J Clin Oncol, 2023 Mar 24. doi:
10.1007/s10147-023-02326-w. Online ahead of print.
125.Tomita M, Okabe H, Masuda T, Ono A, Kuroda D, Kuroki H, Hirota M, Hibi T, Baba
H, Sugita H: A case of accessory hepatic duct entering cystic duct successfully treatedby laparoscopic cholecystectomy for cholecystolithiasis. Asian J Endosc Surg, 2023
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126.Yoshida N, Eto K, Baba Y, Hiyoshi Y, Watanabe M, Kurashige J, Iwagami S,
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9）分子薬理学講座
1.

Yamane, T., Kanamori, Y., Sawayama, H., Yano, H., Nita, A., Ohta, Y., Hinokuma,
H., Maeda, A., Iwai, A., Matsumoto, T., Shimoda, M., Niimura, M., Usuki, S.,
Yasuda-Yoshihara, N., Niwa, M., Baba, Y., Ishimoto, T., Komohara, Y., Sawa, T.,
Hirayama, T., Baba, H., and Moroishi, T.
Iron

accelerates

Fusobacterium

nucleatum-induced

CCL8

expressioninmacrophages and is associated with colorectal cancer progression.
JCI insight 7, e156802 (2022).
2.

Bu, L., Yonemura, A., Yasuda-Yoshihara, N., Uchihara, T., Ismagulov, G., Takasugi,
S., Yasuda, T., Okamoto, Y., Kitamura, F., Akiyama, T., Arima, K., Itoyama, R.,
Zhang, J., Fu, L., Hu, X., Wei, F., Arima, Y., Moroishi, T., Nishiyama, K., Sheng, G.,
Mukunoki, T., Otani, J., Baba, H., and Ishimoto, T.
Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation
and angiogenesis in pancreatic cancer.
Cancer Sci. 113, 3579-3592 (2022).

3.

Horiguchi, H., Kadomatsu, T., Yumoto, S., Masuda, T., Miyata, K., Yamamura, S.,
Sato, M., Morinaga, J., Ohtsuki, S., Baba, H., Moroishi, T., and Oike, Y.
Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.
Oncogene 41, 4028-4041 (2022).

4.

Shinchi, H., Komaki, F., Yuki, M., Ohara, H., Hayakawa, N., Wakao, M., Cottam,
H.B., Hayashi, T., Carson, D.A., Moroishi, T., and Suda, Y.
Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic SmallMolecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.
ACS Chem. Biol. 17, 957-968 (2022).

5.

Nomoto, D., Baba, Y., Liu, Y., Tsutsuki, H., Okadome, K., Harada, K., Ishimoto, T.,
Iwatsuki, M., Iwagami, S., Miyamoto, Y., Yoshida, N., Watanabe, M., Moroishi, T.,
Komohara, Y., Sawa, T., Baba, H.
Fusobacterium nucleatum promotes esophageal squamous cell carcinoma
progression via the NOD1/RIPK2/NF-kappaB pathway.

Cancer Lett. 530, 59-67 (2022).
6.

Yu, L., Zhou, D., Zhang, G., Ren, Z., Luo, X., Liu, P., Plouffe, S.W., Meng, Z.,
Moroishi, T., Li, Y., Zhang, Y., Brown, J.H., Liu, S., and Guan, K.L.
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellularsenescence.
Mol. Oncol. 16, 607-629 (2022).

10）幹細胞ストレス学講座(# and * indicate co-first and corresponding author, respectively)
1.

Liu X, Sato N, Yabushita T, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa
T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Saito M, Kinouchi C,
Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O’Brien E,
Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T,
Goyama S*. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses thedevelopment of MLL-fusion leukemia. EMBO Mol Med, 2022 Dec 1;e15631.

2.

Sezaki M#, Hayashi Y#, Nakato G, Wang Y, Nakata S, Biswas S, Morishima T,
Fakruddin M, Moon J, Ahn S, Kim P, Miyamoto Y, Baba H, Fukuda S, Takizawa H*.
Hematopoietic stem and progenitor cells integrate microbial signals to promote postinflammation gut tissue repair. EMBO J., 2022 Oct 18;e110712.

3.

Takihara Y., Higaki T., Yokomizo T., Umemoto T., Ariyoshi K., Hashimoto M.,
Sezaki M., Takizawa H., Inoue T., Suda T., Mizuno H. Bone marrow imaging reveals
the migration dynamics of neonatal hematopoietic stem cells. Commun Biol.,2022
Aug 2;5(1):776.

4.

Fujita S, Morikawa T, Tamaki S, Sezaki M, Takizawa H, Okamoto S, Kataoka K,
Takubo K. Quantitative analysis of sympathetic and nociceptive innervation acrossbone marrow regions in mice. Exp. Hematol., 2022 August–September;112-113: 4459.e6

5.

Kovtonyuk LV, Caiado F, Garcia-Martin S, Manz EM, Helbling PM, Takizawa H,

Boettcher S, Al-Shahrour F, Nombela-Arrieta C, Slack E, Manz MG*. IL-1 mediates
microbiome-induced inflammaging of hematopoietic stem cells in mice. Blood, 2022
Jan 6;139(1):44-58.
6.

Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga
Londoño M, Sham K, Mantica G, Morishima T, Mitchell E, Lidonnici MR, MeierAbt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK,
Göttgens B, Saeb-Parsy K, Frontini M, Laurenti E. Unique molecular and functionalfeatures of extramedullary hematopoietic stem and progenitor cell reservoirs inhumans. Blood, 2022 Jun 9;139(23):3387-3401.

7.

Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K,
Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki
M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu
N, Takaku T, Kitamura T*. Eliminating chronic myeloid leukemia stem cells by
IRAK1/4 inhibitors. Nat Commun., 2022 Jan 12;13(1):271.

8.

Ahmed K, Arima Y, Tabata N, Ishii M, Sato R, Yamashita T, Yamanaga K, Takizawa
H, Hokimoto S, Sueta D, Araki S, Fujisue K, Takashio S, Fujimoto K, Shimomura H,
Tsunoda R, Hirose T, Sato K, Kikuta K, Sakaino N, Nakamura S, Yamamoto N,
Matsumura T, Kajiwara I, Tayama S, Sakamoto T, Nakao K, Oshima S, Yamamoto
E, Sakamoto K, Kaikita K, Matsushita K, Tsujita K. Impact of cerebrovascularcomorbidity on prognosis in Japanese patients undergoing PCI: 1-year data fromJapanese multicenter registry (KICS). Heart Vessels., 2022 Jan 11.

Review (# and * indicate co-first and corresponding author, respectively)
1.

Ho NP, Takizawa H*. Inflammation regulates haematopoietic stem cells and theirniche. Int. J. Mol. Sci., 2022 Jan 20;23(3):1125.

11）消化器内科学講座
1.

Inoue T, Funatsu Y, Ohnishi M, Isogawa M, Kawashima K, Tanaka M, Moriya K,
Kawaratani H, Momoda R, Iio E, Nakagawa H, Suzuki Y, Matsuura K, Fujiwara K,

Nakajima A, Yoshiji H, Nakayama J, Tanaka Y(Corresponding)：
Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus
infection. Liver Int.42(1)124-134,2022
2.

Abounouh K, Kayesh MEH, Altawalah H, Kitab B, Murakami S, Ogawa S, Tanaka
Y, Dehbi H, Pineau P, Kohara M, Benjelloun S, Tsukiyama-Kohara K, Ezzikouri S：
Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
Mol Biol Rep.49(1)403-412,2022

3.

Kayesh M-E-H, Hashem M-A, Sanada T, Kitab B, Rashid M-H-O, Akter L, Ezzikouri
S, Murakami S, Ogawa S, Tanaka Y, Kohara M and Tsukiyama-Kohara K：
Characterization of innate immune response to hepatitis B virus genotype F acuteinfection in tree shrew (Tupaia belangeri) model.
Front Virol. 2:92683,2022. doi: 10.3389/fviro.2022.926831.

4.

Suzuki T,Inoue T,Matsuura K,Kusumoto S,Hagiwara S,Ogawa S,Yagi S,Kaneko
A,Fujiwara K,Watanabe T,Aoyagi K,Urata Y,Tamori A,Kataoka H, Tanaka
Y.(Corresponding)：
Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay
to determine the initiation of treatment for HBV reactivation.
J Gastroenterol.57(7)486-494,2022

5.

Matsui T, Hamada-Tsutsumi S, Naito Y, Nojima M, Iio E, Tamori A, Kubo S, Ide T,
Kondo Y, Eguchi Y, Komori A, Morine Y, Shimada M, Utsunomiya T, Shirabe K,
Kimura K, Hiasa Y, Chuaypen N, Tangkijvanich P, Ito-Naiki A, Takahashi S, Ochiya
T, Tanaka Y(Corresponding)：
Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA
predictor in nonviral hepatocellular carcinoma. Hepatol Res.52(1)93-104,2022

6.

Matsuno K, Sonoda T, Tanaka Y(Corresponding)：Ischemic change in gastric mucosa
due to gastric wall expansion with air supply: Real-time capture in uppergastrointestinal endoscopy. Dig Endosc. e113-e114,2022

7.

Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C,
Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T,
Tanaka Y. (Corresponding) and Matsunaga T：Ivermectin Inhibits HBV Entry into
the Nucleus by Suppressing KPNA2. Viruses.14(11)2468,20228.

Shao X, Uojima H, Arai T, Ogawa Y, Setsu T, Atsukawa M, Furuichi Y, Arase Y,
Horio K, Hidaka H, Nakazawa T, Kako M, Kagawa T, Iwakiri K, Nakajima A, Terai
S, Tanaka Y, Koizumi W：The risk of cirrhosis and its complications based on
PNPLA3 rs738409 G allele frequency. Dig Dis.40(5)625-634,2022

9.

Vincent JP, Ndow G, Ogawa S, Ceesay A, Njie R, Sanneh B, Baldeh I, D’Alessandro
U, Mendy M, Thursz M, Chemin I, Tanaka Y, Lemoine M, Shimakawa Y：
Mac-2 Binding Protein Glycosylation isomer (M2BPGi) to evaluate liver fibrosis andcancer in HBV-infected patients in West Africa. J Glob Health.12:04076,2022

10. Kawata K, Atsukawa M, Ohta K, Chida T, Noritake H, Arai T, Iwakiri K, Yasuda S,
Toyoda H, Okubo T, Hiraoka A, Watanabe T, Uojima H, Nozaki A, Tani J, Morishita
A, Kageyama F, Sasada Y, Nagasawa M, Matsushita M, Oyaizu T, Mikami S,
Ikegami T, Abe H, Matsuura K, Tanaka Y, Tsubota A：Mac-2-Binding Protein Glycan
Isomer Predicts All Malignancies Post-sustained Virological Response in Chronic
Hepatitis C. Hepatol Commun. 6(8):1855-1869,2022
11. Hagiwara S, Kusumoto S, Inoue T, Ogawa S, Narita T, Ito A, Ri M, Komatsu H,
Suzuki T, Matsuura K, Yagi S, Kaneko A, Aoyagi K, Iida S, Tanaka Y.
(Corresponding)：Management of hepatitis B virus (HBV) reactivation in patientswith resolved HBV infection based on a highly sensitive HB core-related antigen
assay. Hepatol Res, 52(9)745-753,2022
12. Tokunaga T, Tateyama M, Tanaka K, Narahara S, Inada H, Kurano S, Hayashi S,
Yoshimaru Y, Nagaoka K, Watanabe T, Setoyama H, Tanaka M, Tanaka
Y.(Corresponding)：Optimal management of lenvatinib therapy for patients withunresectable hepatocellular carcinoma by balancing the therapeutic effect with therelative dose intensity. Hepatol Res.52(1)105-119,2022

13. Yuen M-F, Heo J, Kumada H, Suzuki F, Suzuki Y, Xie Q, Jia J, Karino Y, Hou J,
Chayama K, Imamura M, Lao-Tan J-Y, Lim S-G, Tanaka Y, Xie W, Yoon J-H, DuanZ, Kurosaki M, Sung-Park J, Labio M-E, Kumar R, Kweon Y-O, Yim H-J, Tao Y,
Cremer J, Elston R, Davies M, Baptiste-Brown S, Han K, Campbell F-M, Paff M,
Theodore D：Phase IIa, randomised, double-blind study of GSK3389404 in patientswith chronic hepatitis B on stable nucleos(t)ide therapy.
J Hepatol.S0168-8278(22)00351-8,2022
14. Sonneveld M-J, Chiu S-M, Park J-Y, Brakenhoff S-M, Kaewdech A, Seto W-K,
Tanaka Y, Carey I, Papatheodoridi M, Bömmel F-V, Berg T, Zoulim F, Ahn S-H,
Dalekos G-N, Erler N-S, Siederdissen C-H-Z, Wedemeyer H, Cornberg M, Yuen MF, Agarwal K, Boonstra A, Buti M, Piratvisuth T, Papatheodoridis G, Chen C-H,
Maasoumy B, CREATE study group：
Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBVgenotype and viral antigen levels. J Hepatol.76(5)1042-1050,2022
15. Park J, Le AK, Tseng TC, Yeh ML, Jun DW, Trinh H, Wong G LH, Chen CH, Peng
CY, Kim SE, Oh H, Kwak MS, Cheung KS, Toyoda H, Hsu YC, Jeong JY, Yoon EL,
Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong
SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai
CY, Tseng, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi
Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML,
Kao JH, Yang HI, Nguyen MH：Progression Rates by Age, Sex, Treatment, andDisease Activity by AASLD and EASL Criteria: Data for Precision Medicine.
Clin Gastroenterol Hepatol.20(4)874-855.e4,2022
16. Shimakawa Y, Ndow G, Cerceau T, Ceesay A, Kaneko A, Hasegawa A, Yamamoto
N, Aoyagi K, Vincent J-P, Watanabe T, Baba M, Sanneh B, Baldeh I, Njie R,
D’Alessandro U, Mendy M, Chemin I, Thursz N-R, Lemoine M, and Tanaka
Y(Corresponding)：Rapid point-of-care test for hepatitis B core-related antigen to
diagnose high viral load in resource-limited settings.
Clin Gastroenterol Hepatol. S1542-3565(22)00554-7,2022

17. Atsukawa A, Tsubota A, Kondo C, Koyano K-S, Ishikawa T, Toyoda H, Takaguchi
K, Watanabe T, Matsuura K, Ogawa C, Hiraoka A, Okubo H, Tateyama M, Uojima
H· Nozaki A,·Chuma M, Kato K, Mikami S, Tani J, Morishita A, Kawata K, Tada T,
Furuichi Y, Okubo T, Kawano T, Arai T, Naoto Kawabe N, Kawamura N, Ikegami T,
Nakamuta M, Shigefuku R, Iwasa M, Tanaka Y, Hatano M, Iwakiri K：Risk factors
for portopulmonary hypertension in patients with cirrhosis: a prospective,
multicenter study.
Hepatol Int. Dec 7. doi: 10.1007/s12072-022-10456-y. Online ahead of print. 2022
18. Nagura Y, Matsuura K, Iio E, Fujita K, Inoue T, Matsumoto A, Tanaka E, Nishiguchi
S, Kang J-H, Matsui T, Enomoto M, Ikeda H, Watanabe T, Okuse C, Tsuge M,
Atsukawa M, Tateyama M Kataoka H, Tanaka Y：Serum miR-192-5p levels predict
the efficacy of pegylated interferon therapy for chronic hepatitis B.
PLoS One.17(2)e0263844,2022
19. Atsukawa M, Tsubota A, Kondo C, Toyoda H, Nakamuta M, Takaguchi K, Watanabe
T, Hiraoka A, Uojima H, Ishikawa T, Iwasa M, Tada T, Nozaki A, Chuma M,
Fukunishi S, Asano T, Ogawa C, Abe H, Kato K, Hotta N, Shima T, Matsuura K,
Mikami S, Tachi Y, Fujioka S, Okubo H, Shimada N, Tani J, Morishita A, Hidaka I,
Moriya A, Tsuji K, Akahane T, Okubo T, Arai T, Kitamura M, Morita K, Kawata K,
Tanaka Y, Kumada T, Iwakiri K; KTK49 Liver Study Group：Time-course changes
in liver functional reserve after successful sofosbuvir/velpatasvir treatment inpatients with decompensated cirrhosis. Hepatol Res.52(3)235-246,2022
20. Nakano M, Yatsuhashi H, Bekki S, Takami Y, Tanaka Y, Yoshimaru Y, Honda K,
Komorizono Y, Harada M, Shibata M, Sakisaka S, Shakado S, Nagata K, Yoshizumi
T, Itoh S, Sohda T, Oeda S, Nakao K, Sasaki R, Yamashita T, Ido A, Mawatari S,
Nakamuta M, Aratake Y, Matsumoto S, Maeshiro T, Goto T, Torimura T：Trends inhepatocellular carcinoma incident cases in Japan between 1996 and 2019.
Sci Rep.12(1)1517,2022
21. Hayama K, Atsukawa M, Tsubota A, Kondo C, Iwasa M, Hasegawa H, Takaguchi K,

Tsutsui S, Uojima H, Hidaka H, Okubo H, Suzuki T, Matsuura K, Tada T, Kawabe N
Tani J, Morishita A, Ishikawa T, Arase Y, Furuichi Y, Kato K, Kawata K, Chuma M,
Nozaki A, Hiraoka A, Watanabe T, Kagawa T, Toyoda H, Taniai N, Yoshida H,
Tanaka Y, Iwakiri K, Ktk Liver Study Group：Clinical outcomes of antithrombin IIIbased therapy for patients with portal vein thrombosis:
A retrospective, multicenter study

Hepatol Res.53(1) 51-60,2023

22. Matsuno K, Miyamoto H, Kitada H, Yoshimatsu S, Tamura F, Sakurai K,
Fukubayashi K, Shono T, Setoyama H, Matsuyama T, Suko S, Narita R, Honda M,
Tateyama M, Naoe H, Morinaga J, Tanaka Y, Gushima R：Comparison of endoscopic
submucosal resection with ligation and endoscopic submucosal dissection for small
rectal neuroendocrine tumors: A multicenter retrospective study.
DEN Open. 3, e163,2023
23. Sugahara G, Yuji IshidaY, Lee J-J, Li M, Tanaka Y, Eoh H, Higuchi Y, and Saito T：
Long-Term Cell Fate and Functional Maintenance of Human Hepatocyte throughStepwise Culture Configuration.

FASEB J. 37(2) e22750,2023

24. Janssen H-L, Hou J, Asselah T, Chan H-LY, Zoulim F, Tanaka Y, Janczewska E,
Nahass R G, Bourgeois S, Buti M, Lampertico P, Lenz O, Verbinnen T,
Vandenbossche J, Talloen W, Kalmeijer R, Beumont M, Biermer M, Shukla U：
A Randomized Phase 2 Study (JADE) of the HBV Capsid Assembly Modulator JNJ56136379 With or Without a Nucleos(t)ide Analogue in Patients With Chronic
Hepatitis B Infection.
Gut. 23 Jan 2023, http://dx.doi.org/10.1136/gutjnl-2022-328041〇神経・感覚・運動器研究部門
12）脳神経内科学講座
1.

Kinoshita Y, Ikeda T, Miyamura T, Ueda Y, Yoshida Y, Ueda M, Haraoka S, Kushima
H, Ishii H. Nodular Pulmonary Amyloidosis Associated with Sjögren's Syndrome.
Intern Med, 61: 877-881, 2022

2.

Takashio S, Yamada T, Nishi M, Morioka M, Nakashima N, Hirakawa K, Hanatani

S, Usuku H, Yamamoto E, Ueda M, Matsushita K, Kaikita K, Tsujita K. Sex-relateddifferences in the clinical characteristics of wild-type transthyretin amyloidosis
cardiomyopathy. J Cardiol, 79: 50-57, 2022
3.

Naganuma M, Inatomi Y, Yonehara T, Nakajima M, Ueda M. Underdosed direct oral
anticoagulants in atrial fibrillation patients reduce stroke severity and improveoutcome. Cerebrovasc Dis, 51:473-480, 2022

4.

Benson MD, Berk JL, Dispenzieri A, Damy T, Gillmore JD, Hazenberg BP, Lavatelli
F, Picken MM, Röcken C, Schönland S, Ueda M, Westermark P. Tissue biopsy forthe diagnosis of amyloidosis: experience from some centres. Amyloid, 29: 8-13, 2022

5.

Takahashi K, Sasaki D, Yamashita M, Sakaue T, Enomoto D, Morioka H, Uemura S,
Okura T, Ikeda S, Kono T, Hiratsuka Y, Saijo A, Yamamura N, Kitazawa S, Yamashita
T, Ueda M. Amyloid deposit corresponds to technetium-99mpyrophosphate
accumulation in abdominal fat of patients with transthyretin cardiac amyloidosis. J
Nucl Cardiol, 29: 3126-3136, 2022

6.

Yamakawa M, Nakahara K, Nakanishi T, Nomura T, Ueda M. Miller Fisher
Syndrome following vaccination against SARS-CoV-2: a case report. Intern Med,
61: 1067-1069, 2022

7.

Tasaki M, Oishi T, Ueda M. EGF-containing fibulin-like extracellular matrix protein
1 (EFEMP1) amyloid deposits in the lower rectum from aged patient with bloodystools. Pathol Int, 72: 217-218, 2022

8.

Hayashi H, Oda S, Kidoh M, Nakaura T, Morita K, Nagayama Y, Yoneda T, Takashio
S, Misumi Y, Ueda M, Tsujita K, Hirai T. Can myocardial susceptibility
quantification be an imaging biomarker for cardiac amyloidosis? Jpn J Radiol, 40:
500-507. 2022

9.

Yumoto S, Doi K, Higashi T, Shimao Y, Ueda M, Ishihara A, Adachi Y, Ishiodori H,
Honda S, Baba H. Intra-abdominal bleeding caused by amyloid transthyretinamyloidosis in the gastrointestinal tract: a case report. Clin J Gastroenterol, 15: 140145, 2022
10. Takashio S, Tokitsu T, Matsukawa M, Sakaino N, Fujimoto K, Sakamoto T, Noda K,
Tsunoda R, Misumi I, Hirai N, Doi H, Koide S, Mizuno Y, Hirose T, Kurokawa H,
Kajiwara I, Ohba K, Miyamoto S, Araki S, Yamamoto E, Matsushita K, Ueda M,
Tsujita K; Kumamoto Cardiac Amyloid Survey Investigators. Incidence, clinicalcharacteristics, and diagnostic approach in transthyretin amyloid cardiomyopathy:
The Kumamoto Cardiac Amyloidosis Survey. J Cardiol, 80: 49-55, 2022
11. Moriyama H, Kitakata H, Endo J, Ikura H, Sano M, Tasaki M, Sakai S, Ueda M,
Fukuda K. Step-by-step typing for the accurate diagnosis of concurrent light chain
and transthyretin cardiac amyloidosis. ESC Heart Fail, 9: 1474-1477, 2022
12. Ikura H, Kitakata H, Endo J, Moriyama H, Sano M, Tsujikawa H, Sawano M, Masuda
T, Ohki T, Ueda M, Kosaki K, Fukuda K. Three patients of transthyretin amyloidosis
in a Japanese family with amyloidogenic transthyretin Thr49Ser (p.Thr69Ser) variant.
Eur J Med Genet, 65: 104451, 2022
13. Singu T, Nakajima M, Ueda A, Nakahara K, Nomura T, Kojima S, Inoue T, Ueda M.
Transient optic neuritis and perineuritis associated with anti-MOG antibody after
SARS-CoV-2 mRNA vaccination. Neuroimmunology Reports, 2: 100077, 2022
14. Usuku H, Takashio S, Yamamoto E, Yamada T, Egashira K, Morioka M, Nishi M,
Komorita T, Oike F, Tabata N, Ishii M, Yamanaga K, Fujisue K, Sueta D, Arima Y,
Araki S, Oda S, Misumi Y, Kawano H, Matsushita K, Ueda M, Matsui H, Tsujita K.
Prognostic value of right ventricular global longitudinal strain in transthyretin
amyloid cardiomyopathy. J Cardiol, 80: 56-63, 2022
15. Inoue Y, Nakajima M, Inatomi Y, Masuda T, Misumi Y, Nomura T, Uetani H, Hirai
T, Ueda M. Reversible periventricular hyperintensity lesions in cerebral amyloid
angiopathy (CAA): A case mimicking CAA-related inflammation. Intern Med,
61:3581-3584, 2022

16. Oike F, Usuku H, Yamamoto E, Marume K, Takashio S, Ishii M, Tabata N, Fujisue
K, Yamanaga K, Sueta D, Hanatani S, Arima Y, Araki S, Oda S, Kawano H, Soejima
H, Matsushita K, Ueda M, Fukui T, Tsujita K. Utility of left atrial and ventricularstrain for diagnosis of transthyretin amyloid cardiomyopathy in aortic stenosis. ESC
Heart Fail, 9: 1976-1986, 2022
17. Nakashima N, Takashio S, Morioka M, Nishi M, Yamada T, Hirakawa K, Ishii M,
Tabata N, Yamanaga K, Fujisue K, Sueta D, Kanazawa H, Hoshiyama T, Hanatani S,
Araki S, Usuku H, Yamamoto E, Ueda M, Matsushita K, Tsujita K. A simple staging
system using biomarkers for wild-type transthyretin amyloid cardiomyopathy inJapan. ESC Heart Fail, 9: 1731-1739, 2022
18. Takahashi Y, Date H, Oi H, Adachi T, Imanishi N, Kimura E, Takizawa H, Kosugi S,
Matsumoto N, Kosaki K, Matsubara Y; IRUD Consortium, Mizusawa H. Six years'
accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide
project in Japan to discover causes, mechanisms, and cures. J Hum Genet, 67: 505513, 2022
19. Kawano Y, Hata H, Takashio S, Tsujita K, Ueda M, Matsuoka M. Daratumumab,
lenalidomide and dexamethasone in newly diagnosed systemic light chain
amyloidosis patients associated with multiple myeloma. Br J Haematol, 198: e38e41, 2022
20. Tasaki M, Nomura T, Uchiyama K, Misumi Y, Nakahara K, Oyama Y, Uesugi N,
Ueda M. Fibrinogen Aalpha-chain amyloidosis associated with a rare frameshift
pathogenic variant p. Arg547GlyfsTer21. Amyloid, 29: 276-277, 2022
21. Nishi M, Takashio S, Morioka M, Fujiyama A, Nakashima N, Hirakawa K, Hanatani
S, Usuku H, Yamamoto E, Kidoh M, Oda S, Gushima R, Matsushita K, Fukushima
S, Ueda M, Tsujita K. Extracardiac biopsy sensitivity in transthyretin amyloidosis
cardiomyopathy patients with positive 99 mTc-labeled pyrophosphate scintigraphy
findings. Circ J, 86:1113-1120, 2022

22. Nakajima M, Watari M, Ando Y, Ueda M. Asymptomatic deep venous thrombosis
identified on routine screening in patients with hospitalized neurological diseases. J
Clin Neurosci, 102:13-20, 2022
23. Morioka M, Takashio S, Nakashima N, Nishi M, Fujiyama A, Hirakawa K, Hanatani
S, Usuku H, Yamamoto E, Kidoh M, Oda S, Matsushita K, Ueda M, Tsujita K.
Correlation between cardiac images, biomarkers, and amyloid load in wild-typetransthyretin amyloid cardiomyopathy. J Am Heart Assoc, 11:e024717, 2022
24. Tahara N, Honda A, Ueda M, Fukumoto Y. Popeye’s sign and transthyretin
amyloidosis. Eur Heart J, 43:3000, 2022
25. Ueda A, Nakajima M, Misumi Y, Nakahara K, Shinriki S, Tasaki M, Matsui H, Ueda
M. Detection of Vascular Notch3 deposits in Unfixed Frozen Skin Biopsy Sample in
CADASIL. Front Neurol, 3:881528, 2022
26. Sato K, Oda S, Kidoh M, Ishiuchi S, Kamimoto M, Kanaya H, Nomura T, Kuyama
N, Ueda M, Tsujita K, Hirai T. Myocarditis in myasthenia gravis: Multiparametricevaluation using cardiac magnetic resonance imaging. Circ J, 86:1788, 2022
27. Matsushita H, Misumi Y, Masuda T, Okada M, Inoue F, Ueda M, Ando Y. Urinarytransthyretin as a biomarker in ATTRv amyloidosis. Pathophysiology, 29: 333-343,
2022
28. Tasaki M, Misumi Y, Nomura T, Kamba T, Ueda M. Detection of semenogelin 1amyloidosis through immunohistochemical staining with novel antibodies developed
based on mass spectrometric peptide mapping analysis. Amyloid, 29: 278-280, 2022
29. Iwahashi N, Ikezaki M, Komohara Y, Fujiwara Y, Noguchi T, Nishioka K, Sakai K,
Nishio K, Ueda M, Ihara Y, Uchimura K, Ino K, Nishitsuji K. Cytoplasmic p53
aggregates accumulated in p53-mutated cancer correlate with poor prognosis. PNAS
Nexus, 1:128, 2022

30. Misumi Y, Ando Y, Ueda M. Early transverse tubule involvement in cardiomyocytes
in hereditary transthyretin amyloidosis; A possible cause of cardiac events.
Cardiovasc Pathol, 61:107458, 2022
31. Inoue Y, Tasaki M, Masuda T, Misumi Y, Nomura T, Yukio Ando Y, Ueda M. αEnolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation.
Cell Mol Life Sci, 79: 462, 2022.
32. Yi K, Nakajima M, Ikeda T, Yoshigai M, Ueda M. Modified Rankin Scale assessment
on telephone survey using a simple questionnaire. J Stroke Cerebrovasc Dis, 31:
106695, 2022
33. Shimamoto T, Uchino K, Mori A, Nojima K, Iyama J, Misumi Y, Ueda M, Uchino
M. Effects of intensive exercise on cognitive dysfunction in patients with pure
cerebellar degeneration: a single-arm pilot study. Ann Rehabil Med, 46: 263-273,
2022
34. Mizutani H, Sato Y *, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K.*
SIRT7 deficiency protects against Aβ42-induced apoptosis through the regulation of
NOX4-derived reactive oxygen species production in SH-SY5Y cells. Int J Mol Sci,
23: 9027, 2022
35. Ando Y, Adams D, Benson MD, Berk J, Planté-Bordeneuve V, Coelho T, Conceição
I, Ericzon B, Obici L, Rapezzi C, Sekijima Y, Ueda M, Palladini G, Merlini G.
Guidelines and new directions in the therapy and monitoring of ATTRv amyloidosis.
Amyloid, 29: 143-155, 2022
36. Inoue M, Muta K, Fouad A, Mohammed A, Onodera R, Higashi T, Ueda M, ,Ando
Y, Arima H, Jono H, Motoyama K. Potential use of Dendrimer-based TTR-CRISPR
pDNA polyplex for ocular amyloidosis. Biol Pharm Bull, 45: 1660-1668, 2022
37. Inoue M, Higashi T, Hayashi Y, Onodera R, Fujisawa K, Taharabaru T, Yokoyama R,

Ouchi K, Misumi Y, Ueda M, Inoue Y, Mizuguchi M, Saito T, Saido T, Ando Y, Arima
H, Motoyama K, Jono H. Multifunctional therapeutic cyclodextrin-appended
dendrimer complex for treatment of systemic and localized amyloidosis. ACS Appl
Mater Interfaces, 14: 40599-40611, 2022
38. Kidoh M, Oda S, Takashio S, Hirakawa K, Kawano Y, Shiraishi S, Hayashi H,
Nakaura T, Nagayama Y, Funama Y, Ueda M, Tsujita K, Hirai T. Diagnostic
performance of CT-derived extracellular volume fraction versus myocardium-tolumen signal ratio for detecting cardiac amyloidosis. Radiology, 2022 (in press)
39. Misumi Y, Tabata Y, Tasaki M, Obayashi K, Yamakawa S, Nomura T, Ueda M.
Binding of serum-derived amyloid-associated proteins to amyloid fibrils. Amyloid,2022 (in press)
40. Yagita K, Noguchi H, Koyama S, Hamasaki H, Komori T, Aishima S, Kosaka T,
Ueda M, Komohara Y, Watanabe A, Sasagasako N, Ninomiya T, Oda Y, Honda H.
Chronological changes in the expression pattern of hippocampal prion proteinsduring disease progression in sporadic Creutzfeldt-Jakob disease MM1 subtype. J
Neuropathol Exp Neurol, 81: 900-909, 2022
41. Shinriki S, Hirayama M, Nagamachi A, Yokoyama A, Kawamura T, Kanai A, Kawai
H, Iwakiri J, Riu L, Maeshiro M, Tungalag S, Tasaki M, Ueda M, Tomizawa K,
Kataoka N, Ideue T, Suzuki Y, Asai K, Tani T, Inaba T, Matsui H. DDX41 coordinates
RNA splicing and transcriptional elongation to prevent DNA replication stress inhematopoietic cells. Leukemia, 36: 2605-2620, 2022
42. Takahashi K, Morioka H, Sasaki D, Yamamura N, Kitazawa S, Ueda M, Sakaue T,
Enomoto D, Uemura S, Okura T, Ikeda S. Two autopsy cases of wild-typetransthyretin

cardiacamyloidosis

who

died

10

days

after

technetium-

99mpyrophosphate scintigraphy. J Nucl Cardiol, 2022 (in press)
43. Maeda-Ogata S, Tahara N, Tahara A, Bekki M, Honda A, Sugiyama Y, Igata S, Abe
T, Sekijima Y, Ueda M, Ando Y, Fukumoto Y. Treatment response to Tafamidis

quantitatively assessed by serial bone scintigraphy in transthyretin amyloid
cardiomyopathy. J Nucl Cardiol, 2022 (in press)
44. Nakahara K, Takamatsu K, Kudo N, Ito T, Ueda M. Histopathological features ofGerhardt syndrome in a patient with multiple system atrophy: An autopsy case report.
Cureus, 14: e30415, 2022
45. Takeuchi Y, Nomura T, Nakahara K, Ueda M. Autoimmune polyglandular syndrome
with refractory gait disturbance. Intern Med, 2022 (in press)
46. Yamakawa M, Nakane S, Ihara E, Tawara N, Ikeda H, Igarashi Y, Komohara Y,
Takamatsu K, Ikeda T, Tomita Y, Murai S, Ando Y, Mukaino A, Ogawa Y, Ueda M.
A novel murine model of autoimmune dysautonomia by α3 nicotinic AChR
immunization. Front Neurosci, 16: 1006923, 2022
47. Usuku H, Yamamo E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Morioka M,
Komorita T, Oike F, Fujisue K, Hanatani S, Arima Y, Takashio S, Oda S, Kawano H,
Matsushita K, Ueda M, Matsui H, Tsujita K. Time-dependent change of relative
apical longitudinal strain index in patients with wild-type transthyretin amyloid
cardiomyopathy. Int J Cardiol Heart Vasc, 43, 101146, 2022
48. Matsushita H, Sameshima G, Fukunari A, Okada M, Inoue F, Ueda M, Ando Y.
Suppression of amyloid fibril formation by UV irradiation. Journal of Radiation
Research and Applied Sciences, 2022 (in press)
49. Kuyama N, Takashio S, Nagakura T, Imamura M, Takamatsu K, Takae M, Hirakawa
K, Yamanaga K, Hanatani S, Yamamoto E, Matsushita K, MD, Ueda M, Tsujita K.
Anti-Kv1.4 antibody positive myocarditis and myositis despite absence of thymoma
and anti-acetylcoline receptor antibody. JACC Case Rep, 2022 (in press)
50. Goto M, Tasaki M, Ueda M. Early onset Congo red-positive fibrillary
glomerulonephritis associated with glomerular DNAJB9 deposits mimicking renal
amyloidosis. Pathol Int, 2022 (in press)

51. Takahashi K, Hiratsuka Y, Sasaki D, Sakaue T, Enomoto D, Morioka H, Uemura S,
Okura T, Ikeda S, Kono T, Iwamura T, Yamamura N, Kitazawa S, Ueda M. 99mTcpyrophosphate scintigraphy can image tracer uptake in skeletal trunk muscles oftransthyretin cardiac amyloidosis Brief title: Extracardiac PYP uptake in ATTR-CA.
Clin Nucl Med, 48:18-24, 2023
（総説）
1.

Tahara N, Lairez O, Endo J, Okada A, Ueda M, Ishii T, Kitano Y, Lee H, Russo E,
Kubo T. 99mTechnetium-pyrophosphate scintigraphy: a practical guide for early
diagnosis of transthyretin amyloid cardiomyopathy. ESC Heart Fail, 9: 251-262,
2022

2.

Ueda M. Transthyretin: its function and amyloid formation. Neurochem Int. 155:
105313, 202213）分子生理学講座
1.

Adnan N, Khandker SS, Haq A, Chaity MA, Khalek A, Nazim AQ, Kaitsuka T,
Tomizawa K, Mie M, Kobatake E, Ahmed S, Ali NAA, Khondoker MU, Haque M,
Jamiruddin MR. Detection of SARS-CoV-2 by antigen ELISA test is highly swayedby viral load and sample storage condition. Expert Rev Anti Infect Ther. 2022
Mar;20(3):473-481. doi: 10.1080/14787210.2021.1976144.

2.

Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y,
Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono
H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K. Resistance tochemical carcinogenesis induction via a dampened inflammatory response in naked
mole-rats. Commun Biol. 2022 Mar 30;5(1):287. doi: 10.1038/s42003-022-03241y.

3.

Yakita M, Chujo T, Wei FY, Hirayama M, Kato K, Takahashi N, Naganuma K, Nagata
M, Kawahara K, Nakayama H, Tomizawa K. Extracellular N6 -isopentenyladenosine(i6A) addition induces cotranscriptional i6A incorporation into ribosomal RNAs.

RNA. 2022 Jul;28(7):1013-1027. doi: 10.1261/rna.079176.122.
4.

Monde K, Satou Y, Goto M, Uchiyama Y, Ito J, Kaitsuka T, Terasawa H, Monde N,
Yamaga S, Matsusako T, Wei FY, Inoue I, Tomizawa K, Ono A, Era T, Sawa T, Maeda
Y. Movements of Ancient Human Endogenous Retroviruses Detected in SOX2Expressing Cells. J Virol. 2022 May 11;96(9):e0035622. doi: 10.1128/jvi.00356-22.

5.

Matsushita H, Sasaki Y, Yunoki A, Matsuji A, Latt HM, Onishi K, Tomizawa K,
Matsui H. Antidepressant-like effect of male mating behavior through oxytocininduced

CREB

signaling.

Neurosci

Res.

2022

Aug;181:74-78.

doi:

10.1016/j.neures.2022.04.002.
6.

Nagayoshi Y, Nishiguchi K, Yamamura R, Chujo T, Oshiumi H, Nagata H, Kaneko
H, Yamamoto K, Nakata H, Sakakida K, Kunisawa A, Adachi M, Kakizoe Y, Mizobe
T, Kuratsu JI, Shimada S, Nakamori Y, Matsuoka M, Mukoyama M, Wei FY,
Tomizawa K. t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong
Candidate Biomarkers of COVID-19 Infection and Severity. Biomolecules. 2022 Sep
3;12(9):1233. doi: 10.3390/biom12091233.

7.

Shinriki S, Hirayama M, Nagamachi A, Yokoyama A, Kawamura T, Kanai A, Kawai
H, Iwakiri J, Liu R, Maeshiro M, Tungalag S, Tasaki M, Ueda M, Tomizawa K,
Kataoka N, Ideue T, Suzuki Y, Asai K, Tani T, Inaba T, Matsui H. DDX41 coordinates
RNA splicing and transcriptional elongation to prevent DNA replication stress inhematopoietic cells. Leukemia. 2022 Nov;36(11):2605-2620. doi: 10.1038/s41375022-01708-9.

14）知覚生理学講座
1.

Nishimura M, Song W-J: Region-dependent millisecond time-scale sensitivity inspectrotemporal integrations in guinea pig primary auditory cortex. Neuroscience
480: 229-245, 2022.

2.

Zhou B, Tomioka R, Song W-J: Temporal profiles of neuronal responses to repeatedtone stimuli in the mouse primary auditory cortex. Hearing Research (in press).

15）分子脳科学講座
1.

Bundo M, Iwamoto K: A method for detection of somatic LINE-1 insertions at thesingle-cell level from postmortem human brain. Methods in Molecular Biology
2577:147-159, 2023.

2.

Yu Z, Ueno K, Funayama R, Sakai M, Nariai N, Kojima K, Kikuchi Y, Li Z, Ono C,
Kanatani J, Ono J, Iwamoto K, Hashimoto K, Kinoshita K, Nakayama K, Nagasaki
M, Tomita H: Sex-Specific Differences in the Transcriptome of the Human
Dorsolateral Prefrontal Cortex in Schizophrenia. Molecular Neurobiology 2023,
60(2):1083-1098

3.

Du J, Nakachi Y, Fujii A, Fujii S, Bundo M, Iwamoto K: Antipsychotics function as
epigenetic age regulators in human neuroblastoma cells. Schizophrenia (Heidelb),8(1):69, 2022

4.

Sugawara H, Bundo M, Kasahara T, Nakachi Y, Ueda J, Kubota-Sakashita M,
Iwamoto K, Kato T: Cell-type-specific DNA methylation analysis of the frontal
cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted
mitochondrial DNA. Molecular Brain, 15:9, 202216）眼科学講座
1.

Sugisaki K, Inoue T, Yoshikawa K, Kanamori A, Yamazaki Y, Ishikawa S, Uchida K,
Iwase A, Araie M; Advanced Glaucoma Study Members in Japan Glaucoma Society:
Factors threatening central visual function of advanced glaucoma patients: aprospective longitudinal observational study. Ophthalmology 129: 488-497, 2022.

2.

Iraha S, Takihara Y, Urahashi Y, Watanabe T, Nakamura K, Urahashi M, WatanabeKitamura F, Nakashima KI, Takahashi E, Kojima S, Tanihara H, Inoue T: Factors
associated with outcomes of Baerveldt glaucoma implant for open angle glaucoma,
an aging-related eye disease. Scientific Reports 12: 1359, 2022.

3.

Iraha S, Kondo S, Yamaguchi T, Inoue T: Bilateral corneal perforation caused byneurotrophic keratopathy associated with leprosy: a case report. BMC
Ophthalmology 22: 42, 2022.

4.

Singu T, Nakajima M, Ueda A, Nakahara K, Nomura T, Kojima S, Inoue T, Ueda M:
Transient optic neuritis and perineuritis associated with anti-MOG antibody after
SARS-CoV-2 mRNA vaccination. Neuroimmunology Reports 2: 100077, 2022.

5.

Nakamura K, Fujimoto T, Okada M, Maki K, Shimazaki A, Kato M, Inoue T: Tissue
reactivity to, and stability of, glaucoma drainage device materials placed under rabbit
conjunctiva. Translational Vision & Science Technology 11: 9, 2022.

6.

1Iwasaki, Kojima S, Wajima R, Okazaki T, Yokoyama Y, Inoue T, Higashide T, Miki
A, Nakazawa T, Inatani M: Comparing surgical outcomes in neovascular glaucoma
between tube and trabeculectomy: a multicenter study. Ophthalmology Glaucoma 5:
672-680, 2022.

7.

Murakami-Kojima S, Takahashi E, Eguchi-Matsumoto M, Saruwatari J, Nakashima
KI, Inoue T: Risk factors for intraocular pressure elevation in a six-month period
after ab interno trabeculotomy using a Kahook Dual Blade. BMC Ophthalmology
22: 327, 2022.

8.

Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, Sezaki
M, Takizawa H, Inoue T, Suda T, Mizuno H: Bone marrow imaging reveals the
migration dynamics of neonatal hematopoietic stem cells. Communications Biology
5: 776, 2022.

9.

Nakamura K, Kojima S, Inoue-Mochita M, Tanihara H, Inoue T: Elevated solublevascular endothelial growth factor receptor levels in aqueous humor from patientswith different types of glaucoma. Experimental Eye Research 223: 109204, 2022.

10. Murata N, Takahashi E, Saruwatari J, Kojima S, Inoue T: Outcomes and risk factors
for ab interno trabeculotomy with a Kahook dual blade. Graefe’s Archive for Clinicaland Experimental Ophthalmology in press.
11. Asaoka R, Sugisaki K, Inoue T, Yoshikawa K, Kanamori A, Yamazaki Y, Ishikawa S,
Uchida K, Iwase A, Araie M; for Advanced Glaucoma Study Members in Japan
Glaucoma Society: Identifying central 10° visual subfield associated with future
worsening of visual acuity in eyes with advanced glaucoma. Br J Ophthalmol. inpress
12. Funagura N, Fukushima S, Inoue T. Ipilimumab-related uveitis and refractory
hypotony with a flat chamber in a trabeculectomized eye with exfoliation glaucoma:
A case report. American Journal of Ophthalmology Case Report 29:101807, 2023.
13. Kiuchi Y, Inoue T, Shoji N, Nakamura M, Tanito M; Glaucoma Guideline Preparation
Committee, Japan Glaucoma Society. The Japan Glaucoma Society guidelines forglaucoma 5th edition. Japanese Journal of Ophthalmology 67:189-254, 2023.
14. Manako K, Takahashi E, Saruwatari J, Matsumura T, Kojima S, Inoue T. Risk factors
for Baerveldt glaucoma drainage implantation for uveitic glaucoma. Scientific
Reports 13:4473, 2023.
17）整形外科学講座
1.

Hata R, Miyamoto K, Abe Y, Sasaki T, Oguma Y, Tajima T, Arai Y, Matsumoto M,
Nakamura M, Kanaji A, Miyamoto T: Osteoporosis and sarcopenia are associatedwith each other and reduced IGF1 levels are a risk for both diseases in the very oldelderly. Bone. 2023

2.

Furukawa M, Okuyama K, Ninomiya K, Miyamoto T, Yato :. Assessment of theNecessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse
Idiopathic Skeletal Hyperostosis. Spine Surg Relat Res. 6:526-532, 2022

3.

Kodama S, Togami W, Miyamoto T: Psoas Major Skeletal Muscle Mass Is a
Predictive Factor for

Independent Walking After Living

Transplantation. Transplant Proc. 54:2285-2294, 2022

Donor Liver

4.

Watanabe H, Okada H, Hirose J, Omata Y, Matsumoto T, Matsumoto M, Nakamura
M, Saito T, Miyamoto T, Tanaka S: Transcription Factor HematopoieticallyExpressed

Homeobox

Protein(Hhex)

Negatively

Regulates

Osteoclast

Differentiation by Controlling Cyclin-Dependent Kinase Inhibitors. JBMR Plus.
6:e10608, 2022
5.

Soma T, Iwasaki R, Sato Y, Kobayashi T, Ito E, Matsumoto T, Kimura A, Homma F,
Saiki K, Takahashi Y, Miyamoto K, Matsumoto M, Nakamura M, Morita M, Ishii K,
Asoda S, Kawana H, Xingyu Z, Aizawa M, Nakagawa T, Miyamoto T: An ionicsilver coating prevents implant-associated infection by anaerobic bacteria in vitro
and in vivo in mice. Sci Rep. 12:18387, 2022

6.

Kaneko Y, Ozawa SI, Sato Y, Kobayashi T, Matsumoto T, Miyamoto K, Kobayashi
S, Harato K, Hirono S, Matsumoto M, Nakamura M, Niki Y, Miyamoto T: The Stat3
inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis. Biochem
Biophys Res Commun. 636:133-140, 2022

7.

Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y,
Jo S, Leng RX, Otomo N, Kwon YC, Sheng Y, Sugano N, Hwang MY, Li W, Mukai
M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang
M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh
CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park
Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y,
Lee YK, Wang YF, Amano K, Park DJ, Yang W, Tada Y, Lau YL, Yamaji K, Zhu Z,
Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi
Y; Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head;
Yamamoto K, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa
S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC: Biological insights into systemic lupus
erythematosus through an immune cell-specific transcriptome-wide association
study. Ann Rheum Dis. 81:1273-80, 2022

8.

Kimura A, Hirayama A, Matsumoto T, Sato Y, Kobayashi T, Ikeda S, Maruyama M,

Kaneko M, Shigeta M, Ito E, Soma T, Miyamoto K, Soga T, Tomita M, Oya A,
Matsumoto M, Nakamura M, Kanaji A, Miyamoto T: Hao1 Is Not a Pathogenic
Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo.
Metabolites. 12:82, 2022
9.

Fukada K, Tachibana K, Kurashina Y, Kaneko Y, Matsumoto T, Miyamoto T, Niki
Y, Nakamura M, Onoe H: A novel fabrication process of up-scalable microfibershaped tendon-like tissue with high cell density for uniformed macroscale assembly.
Biotechnol Bioeng. 119:1327-1336, 2022

10. Soma T, Iwasaki R, Sato Y, Kobayashi T, Ito E, Matsumoto T, Kimura A, Miyamoto
K, Matsumoto M, Nakamura M, Morita M, Asoda S, Kawana H, Nakagawa
T, Miyamoto T: Osteonecrosis development by tooth extraction in zoledronate
treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or
antibiotics. Sci Rep. 12:19, 2022
11. Furukawa M, Okuyama K, Ninomiya K, Yato Y, Miyamoto T, Nakamura M,
Matsumoto M. Maximum number of bone cross-linked vertebrae: an index for BMD
in diffuse idiopathic skeletal hyperostosis. J Bone Miner Metab. 40:308-316, 2022
12. Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim
JS, Mukai M, Lee YK, Ohmura K, Park DJ, Takahashi D, Ahn GY, Karino K, Kwon
YC, Miyamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto
T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T,
Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y,
Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M,
Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC,
Terao C: Novel susceptibility loci for steroid-associated osteonecrosis of the femoral
head in systemic lupus erythematosus. Hum Mol Genet. 31:1082-1095, 2022
18）筋発生再生分野
1.

Fujimaki S, Ono Y: Murine models of tenotomy-induced mechanical overloading
and tail-suspension-induced mechanical unloading. Method Mol Biol: 2023 in press.

2.

Hirano K, Tsuchiya M, Shiomi A, Takabayashi S, Suzuki M, Ishikawa Y, Kawano Y,
Takabayashi Y, Nishikawa K, Nagao K, Umemoto E, Kitajima Y, Ono Y, Nonomura
K, Shintaku H, Mori Y, Umeda M, Hara Y: The mechanosensitive ion channel
PIEZO1 promotes satellite cell function in muscle regeneration. Life Sci Alliance:
6(2):e202201783, 2022

3.

Chen WJ, Lin IH, Lee CW, Yoshioka K, Ono Y, Yan YT, Yen Y, Chen YF:
Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal
muscle. NPJ Regen Med: 7(1):37, 2022

4.

Sakai H, Yuichiro Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono
Y, Fukada S, Ohkawa Y, Kikugawa T, Saika T, Imai Y: Uhrf1 governs proliferationand differentiation of muscle satellite cells. iScience: 25(3):103928. 2022

5.

Fujimaki S, Matsumoto T, Muramatsu M, Nagahisa H, Horii N, Seko D, Masuda S,
Wang X, Asakura Y, Takahashi Y, Miyamoto Y, Usuki S, Yasunaga KI, Kamei Y,
Nishinakamura R, Minami T, Fukuda T, Asakura A, Ono Y: The endothelial
Dll4−muscular Notch2 axis regulates skeletal muscle mass. Nature Metabolism:
4(2):180-189, 2022

6.

Tsuchiya Y, Ono Y: An in vitro mechanical damage model of isolated myofibers in a
floating culture condition. Bio Protoc: 12(1):e4280, 2022

19）皮膚再生・老化学講座
1.

Raja E, Changarathil G, Oinam L, Tsunezumi J, Ngo YX, Ishii R, Sasaki T,
Imanaka-Yoshida K, Yanagisawa H*, Sada A*: The extracellular matrix fibulin 7
maintains epidermal stem cell heterogeneity during skin aging. EMBO Rep. e55478,
2022.

〇老化モデル研究部門
20）老化・健康長寿学講座
1.

Yamamura K, Kawamura Y, Oka K and Miura K*. Carcinogenesis resistance in thelongest-lived rodent, the naked mole-rat. Cancer Science. Online ahead of print,
2022
2.

Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y,
Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono
H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K*. Resistanceto chemical carcinogenesis induction via a dampened inflammatory response in
naked mole-rats. Communications Biology 5(1):287, 2022

3.

Yamada A, Toya H, Tanahashi M, Kurihara M, Mito M, Iwasaki S, Kurosaka S,
Takumi T, Fox A, Kawamura Y, Miura K, Nakagawa S*. Species-Specific Formationof Paraspeckles in Intestinal Epithelium Revealed by Characterization of NEAT1 in
Naked Mole-rat. RNA (8):1128-1143, 2022

4.

Miura T*, Oguchi K, Yamaguchi H, Nakamura M, Sato K, Kobayashi K, Kutsukake
N, Miura K, Hayashi Y, Hojo M, Maekawa K, Shigenobu S, Kano T and Ishiguro A.
Understanding of superorganisms: collective behavior, differentiation and socialorganization. Artificial Life and Robotics. 27(2): 204-212, 2022

21）疾患モデル分野
1.

Furuhata R, Imasaka M, Sugimoto M, Yoshinobu K, Araki M, Araki K. LincRNAp21 exon 1 expression correlates with Cdkn1a expression in vivo. Genes Cells. 27:
14-24, 2022

2.

Sun Y, Kubota S, Iimori M, Hamashima A, Murakami H, Bai J, Morii M, YokomizoNakano T, Osato M, Araki K, Sashida G. The acidic domain of Hmga2 and thedomain's linker region are critical for driving self-renewal of hematopoietic stem cell.
Int J Hematol. 115: 553-562, 2022

3.

Okumura K, Saito M, Isogai E, Tokunaga Y, Hasegawa Y, Araki K, Wakabayashi, Y.
Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility byalternative polyadenylation. J Invest Dermatol. 142: 2323-2333 e12, 2022

4.

Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R, Fujimura S, Tani N, Takeda
N, Araki K, Ishiguro, K. FBXO47 is essential for preventing the synaptonemal
complex from premature disassembly in mouse male meiosis. iScience 25: 104008,
2022

5.

Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y,
Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono
H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K. Resistance tochemical carcinogenesis induction via a dampened inflammatory response in naked
mole-rats. Commun. Biol. 5: 287, 2022

6.

Sato H, Hatakeyama J, Iwasato T, Araki K, Yamamoto N, Shimamura, K.
Thalamocortical axons control the cytoarchitecture of neocortical layers by areaspecific supply of VGF. Elife. 11: e67549, 2022

7.

Miyazaki S, Funamoto T, Sekimoto T, Kurogi S, Ohta T, Nagai T, Tajima T, Imasaka
M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Hishikawa Y, Chosa, E.
EPLINbeta Is Involved in the Assembly of Cadherin-catenin Complexes in
Osteoblasts and Affects Bone Formation. Acta Histochem Cytochem 55: 99-110,
2022

8.

Sano H, Nakamura A, Yamane M, Niwa H, Nishimura T, Araki K, Takemoto K,
Ishiguro K, Aoki H, Kato Y, Kojima, M. The polyol pathway is an evolutionarily
conserved system for sensing glucose uptake. PLoS Biol. 20: e3001678, 2022

9.

Yamazaki S, Inohara N, Ohmuraya M, Tsuneoka Y, Yagita H, Katagiri T, Nishina T,
Mikami T, Funato H, Araki K, Nakano H. IkBz controls IL-17-triggered gene
expression program in intestinal epithelial cells that restricts colonization of SFB andprevents Th17-associated pathologies. Mucosal Immunol. 15: 1321-1337, 2022

10. Yokomizo T, Ideue T, Morino-Koga S, Tham CY, Sato T, Takeda N, Kubota Y,
Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, Suda T. Independent origins
of fetal liver haematopoietic stem and progenitor cells. Nature. 609: 779-784, 2022

11. Murai, S, Takakura, K, Sumiyama K, Moriwaki K, Terai K, Komazawa-Sakon S,
Seki T, Yamaguchi Y, Mikami T, Araki K, Ohmuraya M, Matsuda M, Nakano H.
Generation of transgenic mice expressing a FRET biosensor, SMART, that responds
to necroptosis. Commun. Biol. 5: 1331, 2022
12. Noda T, Taira A, Shinohara H, Araki, K: The testis-, epididymis-, or seminal vesicleenriched genes Aldoart2, Serpina16, Aoc1l3, and Pate14 are not essential for malefertility in mice. Exp. Anim. in press. 2023.
13. Kawano S, Araki K, Bai J, Furukawa I, Tateishi K, Yoshinobu K, Usuki S, Nimmo
RA, Kaname T, Yoshihara M, Takahashi S, Sashida G, Araki M: A gain-of-function
mutation in micro-RNA-142 is sufficient to cause the development of T-cell leukemia
in mice. Cancer Sci. in press. 2023.
22）公衆衛生学講座
1. Yada H, Odachi R, Adachi K, Abe H, Yonemoto F, Fujiki T, Fujii M, Katoh T.
Validity and reliability of Psychiatric Nurse Self-Efficacy Scales: cross-sectional
study.

BMJ Open. 2(1): e055922. Doi: 10.1136/bmjopen-2021-055922, 2022.

2. Hirata K, Ueda K, Wada K, Ikehara S, Tanigawa K, Kimura T, Ozono K, Iso H,
Kamijima M, Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito
S, Yamagata Z, Inadera H, Nakayama T, Iso H, Shima M, Nakamura H, Suganuma
N,Kusuhara K, Katoh T.
Long-term outcomes of children with neonatal transfer: the Japan Environment andChildren’s Study.
European Journal of Pediatrics. 181(6):2501-2511. Doi: 10.1007/s00431-02204450-7, 2022.
3. Cho K, Kobayashi S, Araki A, Miyashita C, Itoh S, Saijo Y, Ito Y, Sengoku K, Baba
T, Minakami H, Nakamura Y, Kishi R, Kamijima M, Yamazaki S, Ohya Y, Kishi R,
Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera H, Nakayama T, Iso
H, Shima M, Kurozawa Y, Suganuma N, Kusuhara K, Katoh T.

Prenatal alcohol exposure and adverse fetal growth restriction: findings from theJapan Environment and Children’s Study.
Pediatric Research. 92(1): 291-298. Doi: 10.1038/s41390-021-01595-3, 2022.
4. Nakanishi K, Saijo Y, Yoshioka E, Sato Y, Kato Y, Nagaya K, Takahashi S, Ito Y,
Kobayashi S, Miyashita C, Ikeda-Araki A, Kishi R, Kamijima M, Yamazaki S, Ohya
Y, Yaegashi N, Hashimoto K, Mori C, Ito C, Yamagata Z, Inadera H, Nakayama T,
Iso H, Shima M, Kurozawa Y, Suganuma N, Kusuhara K, Katoh T.
Severity of low pre-pregnancy body mass index and perinatal outcomes: the Japan
Environment and Children’s Study.
BMC Pregnancy Childbirth. 22(1):121. Doi: 10.1186/s12884-022-04418-3, 2022.
5. Tatsuta N, Nakai K, F. Nakayama S, Takeuchi A, Arima T, Yaegashi N, Kamijima M,
Yamazaki S, Ohya Y, Kishi R, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera H,
Nakayama T, Iso H, Shima M, Kurozawa Y, Suganuma N,Kusuhara K, Katoh T.
Effects of maternal exposure to lead on secondary sex ratio in Japan: The Japan
Environment and Children’s Study.
Science of The Total Environment. 817:152726. Doi: 10.1016/j.scitotenv.2021, 2022.
6. Kuraoka S, Oda M, Mitsubuchi H, Nakamura K, Katoh T.
Impaired Height Growth Associated with Vitamin D Deficiency in Young Children
from the Japan Environment and Children’s Study.
Nutrients. 14(16): 3325-3325. Doi: 10.3390/nu14163325, 2022.
7. Saijo Y, Yoshioka E, Sato Y, Azuma H, Tanahashi Y, Ito Y, Kobayashi S, Minatoya M,
Ait Bamai Y, Yamazaki K, Itoh S, Miyashita C, Ikeda‐Araki A, Kishi R, Kamijima M,
Yamazaki S, Ohya Y, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera
H, Nakayama T, Iso H, Shima M, Kurozawa Y, Suganuma N, Kusuhara K, Katoh T.
Relations of mold, stove, and fragrance products on childhood wheezing and asthma:
A prospective cohort study from the Japan Environment and Children's Study.
Indoor Air. 32(1): e12931. Doi: 10.1111/ina.12931, 2022.
8. Sato Y, Yoshioka E, Saijo Y, Kato Y, Nagaya K, Takahashi S, Ito Y, Kobayashi S, AitBamai Y, Yamazaki K, Itoh S, Miyashita C, Ikeda‐Araki A, Kishi R, Kamijima M,
Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z,
Inadera H, Nakayama T, Iso H, Shima M, Nakamura H, Suganuma N, Kusuhara K,
Katoh T.
Associated congenital anomalies and syndromes of 248 infants with orofacial clefts
born between 2011 and 2014 in the Japan Environment and Children's Study.
Congenital Anomalies. Doi: 10.1111/cga.12496, 2022.
9. Kunori Y, Saijo Y, Yoshioka E, Sato Y, Kanaya T, Nakanishi K, Kato Y, Nagaya K,
Takahashi S, Ito Y, Itoh S, Kobayashi S, Miyashita C, Ikeda-Araki A, Kishi R,
Kamijima M, Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito
S, Yamagata Z, Inadera H, Nakayama T, Sobue T, Shima M, Nakamura H, Suganuma
N, Kusuhara K, Katoh T.
Evaluating association of smoking status during pregnancy with adverse birthoutcomes using urinary cotinine concentration: The Japan environment and Children's
study (JECS).
Environmental Research. 215:114302. Doi: 10.1016/j.envres.2022.114302, 2022.
10. Fukushige M, Lu X, Satoh M, Oda M, Ohba T, Katoh T.
Association between antinuclear antibody positivity and chemical exposure among
pregnant Japanese women: a cross-sectional study based on the Japan Environment
and Children’s Study.
International Journal of Hygiene and Environmental Health. (In press）
23）神経精神医学講座
1.

Imai T, Ochiai S, Ishimaru T, Daitoku H, Miyagawa Y, Fukuhara R, Boku S,
Takebayashi M.
A case report: Clozapine-induced leukopenia and neutropenia after mRNA COVID19 vaccination. Neuropsychopharmacol Rep. 2022 Jun;42(2):238-240.

2.

Fukunaga H, Sugawara H, Koyama A, Okamoto K, Fukui T, Ishikawa T, Takebayashi
M, Sekiyama K, Hashimoto M.
Relationship between preoperative anxiety and onset of delirium after cardiovascularsurgery in elderly patients: focus on personality and coping process.
Psychogeriatrics. 2022 Jul;22(4):453-459.
3.

Yoshiura K, Fukuhara R, Ishikawa T, Tsunoda N, Koyama A, Miyagawa Y, Hidaka
Y, Hashimoto M, Ikeda M, Takebayashi M, Shimodozono M.
Brain structural alterations and clinical features of cognitive frailty in Japanesecommunity-dwelling older adults: the Arao study (JPSC-AD).
Sci Rep. 2022 May 17;12(1):8202.

4.

Sasaki H, Jono T, Fukuhara R, Honda K, Ishikawa T, Boku S, Takebayashi M.
Late-manifestation of attention-deficit/hyperactivity disorder in older adults: anobservational study. BMC Psychiatry. 2022 May 24;22(1):354.

5.

Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji
S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi
M, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and
Dementia (JPSC-AD) Study Group.
Higher-resolution quantification of white matter hypointensities by large-scaletransfer learning from 2D images on the JPSC-AD cohort.
Hum Brain Mapp. 2022 May 7.

6.

Sugawara H, Koyama A, Maruyama T, Koda Y, Fukunaga H, Ishikawa T,
Takebayashi M, Okamoto K, Fukui T, Hashimoto M.
Prospective clinical intervention study of aripiprazole and risperidone in the
management of postoperative delirium in elderly patients after cardiovascular surgery.
Psychiatry Clin Neurosci. 2022 Jul 6.

7.

Hirata R, Kawashima H, Tsuboi T, Wada K, Takebayashi M, Suwa T.
An Online Survey About Electroconvulsive Therapy in Japan During the COVID-19
Pandemic: Comparison of Early and Recent Stages.
Neuropsychiatr Dis Treat. 2022 Jun 28;18:1277-1285.

8.

Okada-Tsuchioka M, Kajitani N, Omori W, Kurashige T, Boku S, Takebayashi M.

Tetraspanin heterogeneity of small extracellular vesicles in human biofluids and brain
tissue. Biochem Biophys Res Commun. 2022 Oct 30;627:146-151.
9.

Hidaka Y, Hashimoto M, Suehiro T, Fukuhara R, Ishikawa T, Tsunoda N, Koyama A,
Honda K, Miyagawa Y, Yoshiura K, Boku S, Ishii K, Ikeda M, Takebayashi M.
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial
subarachnoid spaces decrease with age. Fluids Barriers CNS. 2022 Oct 28;19(1):82.

10. Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y,

Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono
K, Mimura M, Nakashima K, Iga J, Takebayashi M, Ninomiya T．
CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective
Studies Collaboration for Aging and Dementia.
Kidney Med．2023 Mar;5(3) 100593

doi:10.1016/j.xkme.2022.100593