2023 年度報告
熊本大学大学院生命科学研究部附属健康長寿代謝制御研究センター〇代謝・循環器部門
1）病態生化学講座
1. Yamazaki M, Hino S, Usuki S, Miyazaki Y, Oda T, Nakao M, Ito T, Yamagata K: YAP/BRD4controlled ROR1 promotes tumor-initiating cells and hyperpoliferation in pancreatic cancer.
EMBO J e112614, 2023
2. Tsuyama T, Sato Y, Yoshizawa T, Matsuoka T, Yamagata K:
Hypoxia causes pancreatic b-cell dysfunction and impairs insulin secretion by activating thetranscriptional repressor BHLHE40.
EMBO reports e56227, 2023
3. Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue
X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T, Liang X:
NAD+ salvage governs mitochondrial metabolism invigorating NK cell anti-immunity.
Hepatology 78: 468-485, 2023
4. Yamagata K, Mizumoto T, Yoshizawa T:
The emerging role of SIRT7 in glucose and lipid metabolism.
Cells 13: 48, 2023

2）分子遺伝学講座
1.

Morin aga J, Kashiwaba ra K, Torigoe D, Okad ome Y, Aizawa K, Uemura K,
Kurashima A, Ma tsuna ga E, Fukami H, Horiguchi H, Sato M, Sug izak i T,
Miya ta K, Kado ma tsu T, Mukoyama M, Miyauchi K, Hokimo to S, F ukumoto
Y, Hiro T, Hib i K, Nak agawa Y, Saku ma I, Ozaki Y, Iwata H, Iimu ro S, Daida
H, Shimok awa H, Kimura T, Matsuzak i M, S aito Y, Matsuy ama Y, Nagai R,
Oike Y: Plasma ANGPTL8 levels and risk fo r secondary card iovascular ev ents
in Japanese pa tients with stab le coron ary artery d isease receiv ing statin
therapy. Arterio scler T hromb Vasc Bio l 43 : 1 549-1559, 2023

2.

Kadomatsu T, Hara T, Kurahashi R, Horigu chi H, Mo rin aga J, Miyata K,

Kurano S, Kane maru H, Fukush ima S , Arak i K, Baba M, L inehan M W, Kamba
T, Oike Y: ANGPTL2 -media ted ep igenetic rep ression of MHC -I in tu mor cells
accelera tes tu mor immune evasion. Mol Onco l 17 :2637 -2658, 20 23

3.

Horiguch i H, Kado matsu T, Yamash ita T, Y umoto S, Terada K, S ato M,
Morin aga J, Miya ta K, Oike Y: ANGPTL2 pro motes immune ch eckpoin t
inhibitor -rela ted murin e auto immune myocard itis. Commun Bio l 6 :96 5, 2023

4.

Fukami H, Morinaga J, Nakagami H, Hayash i H, Okadome Y, Matsu naga E,
Kadomatsu T, Horigu chi H, Sato M, Sugizaki T, Miyata K, To rigoe D,
Mukoyama M, Morish ita R, Oike Y: Efficacy and safety in mice o f repeated,
lifelong ad min istration of an ANGPTL3 vaccin e. npj Vaccines 8 :168, 2023

5.

Okadome Y, Mo rinaga J, Yaman ouch i Y, Matsunaga E, Fukami H, Kadomatsu
T, Horiguch i H, Sato M, Sug izak i T, Hayata M, Sakagu chi T, Hirayama R,
Ish imu ra T, Kuwabara T, Usuku K, Yamamo to T, Mukoyama M, Suzuki R,
Fukui T, O ike Y: Inc re ased nu mbers o f p re -o perative circu lating monocytes
predict risk of d evelo p ing card iac surgery -associated acute k idney injury inconditio ns requ iring ca rdio pu lmonary b ypass. Clin Exp Nephrol 27:329-339,
2023

6.

Terada K, Endo M, Kiyonari H, Takeda H, Oike Y: Loss of Dj2 acco mpanies
pH deviation in lyso so mes and lyso some -related organelles. J Cell Physio l ,2023 Online ahe ad of p rin t

7.

Horiguchi H, Kadomatsu T, Yamashita T, Yumoto S, Horino T, Sato M, Terada K,
Miyata K, Ichigozaki Y, Kimura T, Fukushima S, Moroishi T, Oike Y: Tumor
stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy.
Cancer Gene Ther doi: 10.1038/s41417-024-00757-9. Online ahead of print, 2024.

3）代謝内科学講座
1.

Araki H, Matsumura T, Furukawa N, Araki E. Updates of incretin-related drugs for thetreatment of type 2 diabetes. Journal of Diabetes Investigation. 14(2):189-192. 2023.

2.

Araki H, Hino S, Anan K, Kuribayashi K, Etoh K, Seko D, Takase R, Kohrogi K, Hino Y, Ono

Y, Araki E, Nakao M. LSD1 defines the fiber type-selective responsiveness to environmental
stress in skeletal muscle. eLife 12: e84618, 2023.

3.

Matsushima-Nagata K, Matsumura T, Kondo Y, Anraku K, Fukuda K, Yamanaka M, Manabe
M, Irie T, Araki E, Sugiuchi H. Significance of Circulating Remnant Lipoprotein Cholesterol
Levels Measured by Homogeneous Assay in Patients with Type 2 Diabetes.
Biomolecules. 13(3):468. 2023.

4.

Bouchi R, Sugiyama T, Goto A, Ohsugi M, Yoshioka N, Katagiri H, Mita T, Hirota Y, Ikegami
H, Matsuhisa M, Araki E, Yokoyama H, Minami M, Yamazaki K, Jinnouchi H, Ikeda H, Fujii
H, Nogawa M, Kaneshige M, Miyo K, Ueki K. Impact of COVID-19 pandemic on behavioral
changes and glycemic control and a survey of telemedicine in patients with diabetes: A
multicenter retrospective observational study. Journal of Diabetes Investigation. 14(8):9941004. 2023.

5.

Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K,
Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner
BK, Kulkarni RN. Excess pancreatic elastase alters acinar-β cell communication by impairing
the mechano-signaling and the PAR2 pathways.
Cell Metab. 11;35(7):1242-1260.e9. 2023.

6.

Murata Y, Haneda M, Miyakawa N, Nishida S, Kajihara N, Maeda S, Ono K, Hanatani S, Igata
M, Takaki Y, Motoshima H, Kishikawa H, Araki E. A Case of Autoimmune Polyglandular
Syndrome Type 3 Complicated with IgG4-related Disease. Intern Med. 2023. In press.

7.

Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi
H. An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
J Pharmacol Sci. 154(1):37-46. 2024.

4）循環器内科学講座
1.

Kawahara Y, Kanazawa H, Takashio S, Tsuruta Y, Sumi H, Kiyama T, Kaneko S, Ito M,
Hoshiyama T, Hirakawa K, Ishii M, Tabata N, Yamanaga K, Fujisue K, Hanatani S, Sueta D,
Arima Y, Araki S, Usuku H, Nakamura T, Yamamoto E, Soejima H, Matsushita K, Kawano
H, Tsujita K. Clinical, electrocardiographic, and echocardiographic parameters associated withthe development of pacing and implantable cardioverter-defibrillator indication in patients withtransthyretin amyloid cardiomyopathy. Europace. (in press), 2023

2.

Kuyama N, Takashio S, Nagakura T, Imamura M, Takamatsu K, Takae M, Hirakawa K,
Yamanaga K, Hanatani S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Anti-Kv1.4 Antibody

Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis. JACC
Case Rep. 9:101734, 2023
3.

Sumi H, Hoshiyama T, Morihisa K, Noda K, Kaneko S, Kanazawa H, Ishii M, Fujisue K, Sueta
D, Takashio S, Usuku H, Matsushita K, Tsujita K. Effect of Contact Vector Direction on
Achieving Cavotricuspid Isthmus Block. Sci Rep. 13(1):2579, 2023

4.

Takashio S, Morioka M, Ishii M, Morikawa K, Hirakawa K, Hanatani S, Oike F, Usuku H, Kidoh
M, Oda S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Clinical characteristics, outcome, andtherapeutic effect of tafamidis in wild-type transthyretin amyloid cardiomyopathy. ESC Heart
Fail. (in press), 2023

5.

Takashio S，Kato T, Tashima H, Irie H, Komohara Y, Oguni T, Morikawa K, Kuyama N, Tabata
N, Hanatani S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Prevalence of cardiac
amyloidosis in patients undergoing carpal tunnel release with amyloid deposition. Circ J. (inpress), 2023

6.

Usuku H, Yamamoto E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Oike F, Fujisue K, Hanatani
S, Arima Y, Takashio S, Kawano Y, Oda S, Kawano H, Matsushita K, Ueda M, Matsui H,
Matsuoka M, Tsujita K. Prognostic value of right ventricular global longitudinal strain in patientswith immunoglobulin light-chain cardiac amyloidosis. Eur Heart J Open. (in press), 2023

5）細胞病理学講座
1.

Anami T, Ibe Y, Li L, Komohara Y, Hirao H, Harada M, Yano H, Fujiwara Y, Motoshima T,
Yatsuda J, Hibi T, Kamba T. Overexpression of SerpinB9 in non-seminomatous germ cell tumors.
Med Mol Morphol. 2023

2.

Anami T, Pan C, Fujiwara Y, Komohara Y, Yano H, Saito Y, Sugimoto M, Wakita D, MotoshimaT, Murakami Y, Yatsuda J, Takahashi N, Suzu S, Asano K, Tamada K, Kamba T. Dysfunction ofsinus macrophages in tumor-bearing host induces resistance to immunotherapy. Cancer Sci. 2023

3.

Matsubara E, Shinchi Y, Komohara Y, Yano H, Pan C, Fujiwara Y, Ikeda K, Suzuki M. PD-L2
overexpression on tumor-associated macrophages is one of the predictors for better prognosis inlung adenocarcinoma. Med Mol Morphol. 56:250-256, 2023

4.

Oguro A, Fujiyama T, Ishihara Y, Kataoka C, Yamamoto M, Eto K, Komohara Y, Imaoka S,
Sakuragi T, Tsuji M, Shibata E, Kotake Y, Yamazaki T. Maternal DHA intake in mice increased
DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder. J Lipid
Res. 64:100458, 2023.

5.

Yamada R, Ohnishi K, Pan C, Yano H, Fujiwara Y, Shiota T, Mikami Y, Komohara Y. Expression

of macrophage/dendritic cell-related molecules in lymph node sinus macrophages. Microbiol
Immunol. 67:490-500, 2023

6.

Takashio S, Kato T, Tashima H, Irie H, Komohara Y, Oguni T, Morikawa K, Kuyama N, Tabata
N, Hanatani S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Prevalence of Cardiac
Amyloidosis in Patients Undergoing Carpal Tunnel Release With Amyloid Deposition. Circ J.
87:1047-1055, 2023

7.

Panawan O, Silsirivanit A, Chang CH, Putthisen S, Boonnate P, Yokota T, Nishisyama-Ikeda Y,
Detarya M, Sawanyawisuth K, Kaewkong W, Muisuk K, Luang S, Vaeteewoottacharn K, Kariya
R, Yano H, Komohara Y, Ohta K, Okada S, Wongkham S, Araki N. Establishment andcharacterization of a novel cancer stem-like cell of cholangiocarcinoma. Cancer Sci. 114:32303246, 2023

8.

Miura Y, Motoshima T, Anami T, Yano H, Mito R, Pan C, Urakami S, Kinowaki K, Tsukamoto
H, Kurahashi R, Murakami Y, Yatsuda J, Fujiwara Y, Kamba T, Komohara Y.

Predictive valueof CXCL10 for the occurrence of immune-related adverse events in patient with renal cell
carcinoma. Microbiol Immunol. 67:345-354, 2023

9.

Baba Y, Hara Y, Toihata T, Kosumi K, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N,
Komohara Y, Baba H. Relationship between gut microbiome Fusobacterium nucleatum andLINE-1 methylation level in esophageal cancer. Esophagus. 20;704-712, 2023

10. Adawy A, Li L, Hirao H, Irie T, Yoshii D, Yano H, Fujiwara Y, Esumi S, Honda M, Suzu S,
Komohara Y, Hibi T. Potential involvement of IL-32 in cell-to-cell communication between
macrophages and hepatoblastoma. Pediatr Surg Int. 39:275, 2023.
11. Tatetsu H, Watanabe M, Liu J, Tokunaga K, Iwanaga E, Komohara Y, Thrash E, Bassal MA,
Matsuoka M, Tenen DG, Chai L. Dissecting the cell of origin of aberrant SALL4 expression in
myelodysplastic syndrome. Clin Transl Med. 13:e1327, 2023.
12. Saito Y, Fujiwara Y, Miyamoto Y, Ohnishi K, Nakashima Y, Tabata Y, Baba H, Komohara Y.
CD169+ sinus macrophages in regional lymph nodes do not predict mismatch-repair status ofpatients with colorectal cancer. Cancer Med. 10199-10211, 2023
13. Furuta Y, Gushima R, Naoe H, Honda M, Tsuruta Y, Nagaoka K, Watanabe T, Tateyama M,

Fujimoto N, Hirata S, Miyagawa E, Sakata K, Mizuhashi Y, Iwakura M, Murai M, Matsuoka M,
Komohara Y, Tanaka Y. Possible Association of Mutations in the MEFV Gene with the Intestinal
Phenotype of Behçet's Disease and Refractoriness to Treatment. J Clin Med. 12:3131, 2023.
14. Mito R, Iriki T, Fujiwara Y, Pan C, Ikeda T, Nohara T, Suzuki M, Sakagami T, Komohara Y.
Onionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activationinduced by macrophages-derived IL-6 and cell-cell interaction with tumor-associatedmacrophage. Hum Cell. 36:1068-1080, 2023.
15. Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T,
Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K,
Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O, Satou Y, Saya H, Tan P, Baba H,
Ishimoto T.Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of antiPD-1 immunotherapy in fibrotic tumors. Cancer Res. 83:753-770, 2023.
16. Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F,
Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M,
Komohara Y, Baba H, Ishimoto T.
IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms
a cancer-promoting microenvironment. Gastric Cancer. 26:187-202, 2023.
17. Nakamura E, Maekawa K, Saito Y, Matsumoto T, Ogawa M, Komohara Y, Asada Y, Yamashita
A. Altered choline level in atherosclerotic lesions: Upregulation of choline transporter-likeprotein 1 in human coronary unstable plaque. PLoS One. 18:e0281730, 2023.
18. Matsuzaki H, Komohara Y, Yano H, Fujiwara Y, Kai K, Yamada R, Yoshii D, Uekawa K,
Shinojima N, Mikami Y, Mukasa A. Macrophage colony stimulating factor potentially induces
recruitment and maturation of macrophages in recurrent pituitary neuroendocrine tumors.
Microbiol Immunol. 67:90-98, 2023.
19. Ohno Y, Toshino M, Mohammed AFA, Fujiwara Y, Komohara Y, Onodera R, Higashi T,
Motoyama K. Mannose-methyl-β-cyclodextrin suppresses tumor growth by targeting both coloncancer cells and tumor-associated macrophages. Carbohydr Polym. 305:120551, 2023.
20. Matsubara E, Yano H, Pan C, Komohara Y, Fujiwara Y, Zhao S, Shinchi Y, Kurotaki D, Suzuki
M. The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-

Associated Macrophages. Cancers (Basel). 15:2250, 2023.
21. Komohara Y, Kurotaki D, Tsukamoto H, Miyasato Y, Yano H, Pan C, Yamamoto Y, Fujiwara Y.
Involvement of protumor macrophages in breast cancer progression and characterization ofmacrophage phenotypes. Cancer Sci. 2023
22. Honda M, Kadohisa M, Yoshii D, Komohara Y, Hibi T. Intravital imaging of immune responses
in intestinal inflammation. Inflamm Regen. 43:9, 2023.
23. Shinojima N, Ozono K, Yamamoto H, Abe S, Sasaki R, Tomita Y, Kai A, Mori R, Yamamoto T,
Uekawa K, Matsui H, Nosaka K, Matsuzaki H, Komohara Y, Mikami Y, Mukasa A. Lynch
syndrome-associated chordoma with high tumor mutational burden and significant response to
immune checkpoint inhibitors. Brain Tumor Pathol. 40:185-190, 2023.
24. Fukase H, Honda M, Miyamoto H, Nakashima M, Gushima R, Naoe H, Yamada R, Komohara
Y, Tanaka Y. Narrow-band imaging with magnification for the diagnosis of colorectal adenoma
in a patient with Cronkhite-Canada syndrome. DEN Open. 4:e257, 2023.
25. Yamada R, Miyata-Takata T, Tanaka R, Komohara Y, Takata K. Myeloid sarcoma incidentallyfound in lymph nodes dissected for advanced gastric cancer. J Clin Exp Hematop. 63:139-142,
2023.
26. Miura Y, Motoshima T, Anami T, Takemura K, Kinowaki K, Oka S, Urakami S, Kamba T,
Komohara Y. A Case Report of Aggressive Fumarate Hydrase-deficient Renal Cell Carcinoma
With Loss of HLA Antigens. Cancer Diagn Progn.3:522-527, 2023.
27. Tubakihara H, Sawayama H, Komohara Y, Miyamoto Y, Ogawa K, Ohuchi M, Yoshida N, Baba
H. A case of familial adenomatous polyposis with protein-losing enteropathy treated bylaparoscopic total colorectal resection: A literature review. Asian J Endosc Surg. 16: 77-81, 2023
28. Yamamura K, Beppu T, Kinoshita K, Matsumura K, Oda E, Nagayama Y, Motohara T, Miyamoto
H, Matsumura F, Yamada R, Komohara Y, Okabe H, Miyata T, Isiko T. A Laparoscopically
Treated Case of Peritoneal Dissemination Mimicking Liver Metastases from Distal
Cholangiocarcinoma Four Years After the Initial Pancreaticoduodenectomy. Anticancer Res.
43:1863-1867, 2023.

6）細胞医学分野
1.

Kuwayama N, Kujirai T, Kishi Y, Hirano R, Echigoya K, Fang L, Watanabe S, Nakao M, Suzuki
Y, Ishiguro K, Kurumizaka H, and Gotoh Y. HMGA2 directly mediates chromatin condensationin association with neuronal fate regulation. Nature Commun. 14: 6420, 2023.

2.

Ikeda R, Noshiro D, Morishita H, Takada S, Kagaeyama S, Fujioka Y, Funakoshi T, KomatsuHirota S, Arai R, Ryzhii E, Abe M, Koga T, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura
Y, Noda N, and Komatsu

M. Phosphorylation of phase-separated p62 bodies by ULK1

activates a redox-independent stress response. EMBO J. e113349, 2023.
3.

Etoh K, and Nakao M. A web-based integrative transcriptome analysis, RNAseqChef, uncovers
cell/tissue type-dependent action of sulforaphane. J. Biol. Chem. 299: 104810, 2023.

4.

Yamazaki M, Hino S, Usuki S, Miyazaki Y, Oda T, Nakao M, Ito T, and Yamagata K.
YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperpoliferation inpancreatic cancer. EMBO J. e112614, 2023.

5.

Hino S, Sato T, and Nakao M. Chromatin immunoprecipitation sequencing (ChIP-seq) for
detectinghistonemodifications

andmodifiers.

Methods

Mol.

Biol.

(In

book:

Epigenomics), Springer, 2577: 55-64, 2023.

7）心臓発生研究室
1.

Wenjuan Ma, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Ahad Khalilnezhad, Miho
Kataoka, Yuichiro Arima, Yosuke Tanaka, Shigeru Yanagi, Terumasa Umemoto, Toshio Suda.
MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. The EMBO
Journal 43(3) 339-361, 2024

2.

Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi
Miharada, Yosuke Tanaka, Toshio Suda. Metabolic regulation in erythroid differentiation bysystemic ketogenesis in fasted mice. Experimental hematology 129:104124, 2024

3.

Kaoru Mizukami, Hiroki Higashiyama, Yuichiro Arima, Koji Ando, Norihiro Okada, Katsumi
Kose, Shigehito Yamada, Jun K Takeuchi, Kazuko Koshiba-Takeuchi, Shigetomo Fukuhara,
Sachiko Miyagawa-Tomita, Hiroki Kurihara. Coronary artery established through amniote
evolution. eLife 12:e83005, 2023

4.

Kush Ketan Patel, Cynthia Venkatesan, Habiba Abdelhalim, Saman Zeeshan, Yuichiro Arima,
Suvi Linna-Kuosmanen, Zeeshan Ahmed. Genomic approaches to identify and investigate genesassociated with atrial fibrillation and heart failure susceptibility. Human genomics 17(1) 47-47,20238）腎臓内科学講座
1.

Deng QY, Kakizoe Y, Iwata Y, Nakagawa T, Miyasato Y, Nakagawa M, Nishiguchi K, Nagayoshi
Y, Adachi M, Narita Y, Izumi Y, Kuwabara T, Tsuda Y, Mukoyama M: The serine proteaseplasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in
Dahl salt-sensitive rats. Hypertens Res 46 (1): 50-62, 2023.

2.

Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane
S, Kodama T, Sakamori R, Kobayashi S, Eguchi H, Takemura N, Kokudo N, Yokoi H,
Mukoyama M, Tatsumi T, Takehara T: STAT3 is activated by CTGF-mediated tumor-stroma
cross talk to promote HCC progression. Cell Mol Gastroenterol Hepatol 15 (1): 99-119, 2023.

3.

Imasawa T, Saito C, Kai H, Iseki K, Kazama JJ, Shibagaki Y, Sugiyama H, Nagata D, Narita I,
Nishino T, Hasegawa H, Honda H, Maruyama S, Miyazaki M, Mukoyama M, Yasuda H, Wada
T, Ishikawa Y, Tsunoda R, Nagai K, Okubo R, Kondo M, Hoshino J, Yamagata K: Long-term
effectiveness of a primary care practice facilitation program for chronic kidney disease
management: an extended follow-up of a cluster-randomized FROM-J study. Nephrol Dial
Transplant 38 (1): 158-166, 2023.

4.

Izumi Y, Date R, Mizumoto T, Nakagawa T, Kakizoe Y, Adachi M, Kuwabara T, Mukoyama M:
A case of chyluria with nephrotic-range proteinuria caused by lymphatic malformation, leading
to a diagnosis of Klippel-Trenaunay syndrome. CEN Case Rep 12 (2): 205-209. 2023.

5.

Yokoi H, Toda N, Mukoyama M: Generation of conditional KO mice of CCN2 and its functionin the kidney. Methods Mol Biol 2582: 391-409, 2023.

6.

Shibata S, Kobayashi K, Tanaka M, Asayama K, Yamamoto E, Nakagami H, Hoshide S, Kishi T,
Matsumoto C, Mogi M, Morimoto S, Yamamoto K, Mukoyama M, Kario K, Node K, Rakugi H:
COVID-19 pandemic and hypertension: an updated report from the Japanese Society ofHypertension project team on COVID-19. Hypertens Res 46 (3): 589-600, 2023.

7.

Matsumoto C, Shibata S, Kishi T, Morimoto S, Mogi M, Yamamoto K, Kobayashi K, Tanaka M,
Asayama K, Yamamoto E, Nakagami H, Hoshide S, Mukoyama M, Kario K, Node K, Rakugi H:
Long COVID and hypertension-related disorders: a report from the Japanese Society ofHypertension Project Team on COVID-19. Hypertens Res 46 (3): 601-619, 2023.

8.

Okadome Y, Morinaga J, Yamanouchi Y, Matsunaga E, Fukami H, Kadomatsu T, Horiguchi H,
Sato M, Sugizaki T, Hayata M, Sakaguchi T, Hirayama R, Ishimura T, Kuwabara T, Usuku K,
Yamamoto T, Mukoyama M, Suzuki R, Fukui T, Oike Y: Increased numbers of pre-operative
circulating monocytes predict risk of developing cardiac surgery-associated acute kidney injury
in conditions requiring cardiopulmonary bypass. Clin Exp Nephrol 27 (4): 329-339, 2023.

9.

Miyasato Y, Hanna RM, Moringa J, Mukoyama M, Kalantar-Zadeh K: Prognostic nutritional
index as a predictor of mortality in 101,616 patients undergoing hemodialysis. Nutrients 15 (2):311, 2023.
10. Nishio H, Ishii A, Yamada H, Mori KP, Kato Y, Ohno S, Handa T, Sugioka S, Ishimura T,
Ikushima A, Inoue Y, Minamino N, Mukoyama M, Yanagita M, Yokoi H: Sacubitril/valsartan
ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse modelof type 2 diabetes with aldosterone excess. Nephrol Dial Transplant 38 (11): 2517-2527, 2023.
11. Miyasato Y, Hanna RM, Miyagi, Narasaki, Kimura, Moringa J, Mukoyama M, Kalantar-Zadeh
K: Associations of interdialytic weight gain in the long intervals with mortality and residual
kidney function decline. Hemodial Int 27 (3): 326-338, 2023.
12. Fujimoto D, Kuwabara T, Mukoyama M: Need to continue or discontinue RAS inhibitors as CKD
stage advances? Any alternative? Hypertens Res 46 (8): 2048-2050, 2023.
13. Yoshii R, Kajiwara K, Uemura N, Matsushita K, Nakamura T, Tomita M, Mukoyama M:
Successful treatment with rituximab and plasmapheresis of renal involvement of eosinophilic
granulomatosis with polyangiitis. Renal Replacement Therapy 9 (1): 9, 2023.
14. Morinaga J, Kashiwabara K, Torigoe D, Okadome Y, Aizawa K, Uemura K, Kurashima A,
Matsunaga E, Fukami H, Horiguchi H, Sato M, Sugizaki T, Miyata K, Kadomatsu T, Mukoyama
M, Miyauchi K, Hokimoto S, Fukumoto Y, Hiro T, Hibi K, Nakagawa Y, Sakuma I, Ozaki Y,
Iwata H, Iimuro S, Daida H, Shimokawa H, Kimura T, Matsuzaki M, Saito Y, Matsuyama Y,
Nagai R, Oike Y: Plasma ANGPTL8 levels and risk for secondary cardiovascular events inJapanese patients with stable coronary artery disease receiving statin therapy. Arterioscler
Thromb Vasc Biol 43 (8): 1549-1559, 2023.
15. Hou H, Horikawa M, Narita Y, Jono H, Kakizoe Y, Izumi Y, Kuwabara T, Mukoyama M, Saito
H: Suppression of indoxyl sulfate accumulation reduces renal fibrosis in sulfotransferase 1a1deficient mice. Int J Mol Sci 24 (14): 11329, 2023.
16. Miyasato Y, Mukoyama M: More delicate blood pressure management in patients with chronic
kidney disease: Is lower not the better? Hypertens Res 46 (12): 2757-2758, 2023.
17. Fukami H, Morinaga J, Nakagami H, Hayashi H, Okadome Y, Matsunaga E, Kadomatsu T,
Horiguchi H, Sato M, Sugizaki T, Miyata K, Torigoe D, Mukoyama M, Morishita R, Oike Y:
Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine. NPJ
Vaccines 8 (1): 168, 2023.
18. Iwata Y, Deng QY, Kakizoe Y, Nakagawa T, Miyasato Y, Nakagawa M, Nishiguchi K, Nagayoshi
Y, Narita Y, Izumi Y, Kuwabara T, Adachi M, Mukoyama M: A serine protease inhibitor, camostat
mesilate, suppresses urinary plasmin activity and alleviates hypertension and podocyte injury in
Dahl salt-sensitive rats. Int J Mol Sci 24 (21): 15743, 2023.
19. Miyasato Y, Moringa J, Inoue H, Nakayama Y, Adachi M, Izumi Y, Kakizoe Y, Mizumoto T,
Nakagawa T, Fujimoto D, Ono M, Oda A, Kuwabara T, Mukoyama M: Association between
prognostic nutritional index and peritoneal dialysis discontinuation: a retrospective cohort study.

Renal Replacement Therapy 9 (1): 58, 2023.
20. Mukoyama M, Kuwabara T: Pre-dialysis blood pressure and cardiovascular mortality in Japan:
Need for much stricter control? Hypertens Res: published online, Dec. 7, 2023; doi:
10.1038/s41440-023-01523-4.
21. Yoshii R, Kajiwara K, Uemura N, Matsushita K, Nakamura T, Tomita M, Mukoyama M: The
successful treatment of microscopic polyangiitis associated with non-tuberculous mycobacterialpulmonary disease. CEN Case Rep: published online, Dec.9, 2023; doi: 10.1007/s13730-02300839-x.
22. Ono M, Izumi Y, Maruyama K, Yasuoka Y, Hiramatsu A, Aramburu J, Lopez-Rodriguez C,
Nonoguchi H, Kakizoe Y, Adachi M, Kuwabara T, Mukoyama M: Characterization of gene
expression in the kidney of renal tubular cell-specific NFAT5 knockout mice. Am J Physiol
Renal Physiol: published online, Dec. 28, 2023; doi: 10.1152/ajprenal.00233.2023.
23. Yasuoka Y, Izumi Y, Fukuyama T, Oshima T, Yamazaki T, Uematsu T, Kobayashi N, Nanami M,
Shimada Y, Nagaba Y, Mukoyama M, Sands JM, Takahashi N, Kawahara K, Nonoguchi H:
Tubular endogenous erythropoietin protects renal function against ischemic reperfusion injury.
Int J Mol Sci 25 (2): 1223, 2024.
24. Kurasawa S, Kato S, Ozeki T, Akiyama S, Ishimoto T, Mizuno M, Tsuboi N, Kato N, Kosugi T,
Maruyama S; J-MARINE collaborators: Rationale and design of the Japanese Biomarkers in
Nephrotic Syndrome (J-MARINE) study. Clin Exp Nephrol: published online, Jan. 25, 2024;
doi: 10.1007/s10157-023-02449-4.

〇がん・幹細胞研究部門
9）消化器外科学講座
1.

Imai K, Baba H: Initially unresectable colorectal liver metastases: the best therapeutic regimens.
Lancet Oncol 24:711-713, 2023

2.

Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe M, Agoston AT, Jajoo K,
Davison JM, Nason KS, Getz G, Wang KK, Imamura Y, Odze R, Bass AJ, Stachler MD, Zhang
CZ: Genomic signatures of past and present chromosomal instability in Barrett's esophagus andearly esophageal adenocarcinoma. Nat Commun 14:6203, 2023

3.

Mima K, Baba H: Outcomes of patients with frailty and metastatic cancer admitted to theintensive care unit. Lancet Healthy Longev 4:e655-e656, 2023

4.

Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T,
Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K,
Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O, Satou Y, Saya H, Tan P, Baba H,

Ishimoto T: Stromal reprogramming through dual PDGFRalpha/beta blockade boosts the efficacy
of anti-PD-1 immunotherapy in fibrotic tumors. Cancer Res 83:753-770, 2023

5.

Ichida A, Kokudo T, Shimada S, Hatano E, Kubo S, Kato Y, Ishikawa Y, Mori A, Baba H,
Matsuyama Y, Endo I, Yamaue H, Yamamoto M, Kokudo N, Hasegawa K: Liver resection forhepatocellular carcinoma with tumor thrombus in the inferior vena cava or right atrium: A largescale multicenter survey conducted in Japan. Ann Surg 278:e549-e555, 2023

6.

Zhao Y, Peng F, Wang C, Murano T, Baba H, Ikematsu H, Li W, Goel A: A DNA methylationbased epigenetic signature for the identification of lymph node metastasis in T1 colorectal cancer.
Ann Surg 277:655-663, 2023

7.

Kosumi K, Baba Y, Yamamura K, Nomoto D, Okadome K, Yagi T, Toihata T, Kiyozumi Y,
Harada K, Eto K, Sawayama H, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N,
Watanabe M, Baba H: Intratumour Fusobacterium nucleatum and immune response tooesophageal cancer. Br J Cancer 128:1155-1165, 2023

8.

Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T,
Nakagawa S, Mima K, Imai K, Baba H: Hyperglycaemia induces metabolic reprogramming intoa glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZHedgehog signalling axis in pancreatic cancer. Br J Cancer 128:844-856, 2023

9.

Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, Yamashita K, Semba
T, Arima K, Uchihara T, Nishimura A, Bu L, Fu L, Wei F, Zhang J, Tong Y, Wang H, Iwamoto
K, Fukuda T, Nakagawa H, Taniguchi K, Miyamoto Y, Baba H, Ishimoto T: Downregulation of
15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion. JHEP
reports 5:100892, 2023

10. Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O,
Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu
L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto
T: Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic andimmunosuppressive microenvironment in pancreatic cancer. JCI Insight 8:e163022, 2023
11. Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F,
Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M,

Komohara Y, Baba H, Ishimoto T: IL-1beta derived from mixed-polarized macrophages activates
fibroblasts and synergistically forms a cancer-promoting microenvironment. Gastric Cancer
26:187-202, 2023
12. Shiraishi K, Nakaura T, Uetani H, Nagayama Y, Kidoh M, Kobayashi N, Morita K, Yamahita Y,
Tanaka Y, Baba H, Hirai T: Deep learning-based reconstruction and 3D hybrid profile ordertechnique for MRCP at 3T: evaluation of image quality and acquisition time. Eur Radiol
33:7585-7594, 2023
13. Wei F, Uchihara T, Yonemura A, Yasuda-Yoshihara N, Yasuda T, Semba T, Fukuda M, Akiyama
T, Kitamura F, Bu L, Hu X, Fu L, Zhang J, Kariya R, Yamasaki J, Aihara K, Yamashita K, Nagano
O, Okada S, Baba H, Ishimoto T: A novel tdTomato transgenic mouse model to visualize FAPpositive cancer-associated fibroblasts. FEBS J 290:2604-2615, 2023
14. Yasuda T, Baba H, Ishimoto T: Cellular senescence in the tumor microenvironment and contextspecific cancer treatment strategies. FEBS J 290:1290-1302, 2023
15. Uemura N, Hayashi H, Liu Z, Matsumura K, Ogata Y, Yasuda N, Sato H, Shiraishi Y, Miyata T,
Nakagawa S, Mima K, Nitta H, Baba H: Statins exert anti-growth effects by suppressing
YAP/TAZ expressions via JNK signal activation and eliminate the immune suppression by
downregulating PD-L1 expression in pancreatic cancer. Am J Cancer Res 13:2041-2054, 2023
16. Liu Z, Hayashi H, Matsumura K, Uemura N, Shiraishi Y, Sato H, Baba H: Biological and clinicalimpacts of glucose metabolism in pancreatic ductal adenocarcinoma. Cancers 15:498, 2023
17. Yoshida N, Eto K, Matsumoto T, Kosumi K, Imamura Y, Iwatsuki M, Baba Y, Miyamoto Y,
Watanabe M, Baba H: Omental flap wrapping around the esophagogastric anastomosis andassociation with anastomotic leak in esophagectomy for esophageal cancer: A propensity scorematching analysis. J Am Coll Surg 236:189-197, 2023
18. Mima K, Hayashi H, Yumoto S, Matsumoto T, Tsukamoto M, Miyata T, Nakagawa S, Nitta H,
Baba H: Disability in perioperative activities of daily living is associated with worse survival
outcomes following hepatic resection in patients with intrahepatic cholangiocarcinoma. Hepatol
Res 53:135-144, 2023
19. Shindo Y, Nagano H, Kanai M, Kobayashi S, Wada H, Sakai D, Eguchi H, Baba H, Kamachi H,

Takayama T, Ueno M, Takahashi M, Nakagami Y, Yoshimura K, Hatano E, Ioka T: Clinicaloutcomes of second‑line chemotherapy after gemcitabine and cisplatin plus S‑1 treatment forpatients with advanced biliary tract cancer in the KHBO1401‑3A study. Oncol Rep 49:41, 2023
20. Saito Y, Fujiwara Y, Miyamoto Y, Ohnishi K, Nakashima Y, Tabata Y, Baba H, Komohara Y:
CD169(+) sinus macrophages in regional lymph nodes do not predict mismatch-repair status ofpatients with colorectal cancer. Cancer Med 12:10199-10211, 2023
21. Miyamoto Y, Akiyama T, Kato R, Sawayama H, Ogawa K, Yoshida N, Baba H: Prognostic
significance of systemic inflammation indices by K-ras status in patients with metastatic
colorectal cancer. Dis Colon Rectum 66:e809-e817, 2023
22. Harada K, Matsumoto C, Toihata T, Kosumi K, Iwatsuki M, Baba Y, Ohuchi M, Eto K, Ogawa
K, Sawayama H, Iwagami S, Miyamoto Y, Yoshida N, Baba H: C-reactive protein levels after
esophagectomy are associated with increased surgical complications and poor prognosis inesophageal squamous cell carcinoma patients. Ann Surg Oncol 30:1554-1563, 2023
23. Ikenaga N, Miyasaka Y, Ohtsuka T, Nakata K, Adachi T, Eguchi S, Nishihara K, Inomata M,
Kurahara H, Hisaka T, Baba H, Nagano H, Ueki T, Noshiro H, Tokunaga S, Ishigami K,
Nakamura M, Kyushu Study Group of treatment for pancreatobiliary C: A prospective
multicenter phase II trial of neoadjuvant chemotherapy with Gemcitabine plus Nab-Paclitaxel
for borderline resectable pancreatic cancer with arterial involvement. Ann Surg Oncol 30:193202, 2023
24. Kitano Y, Inoue Y, Takeda T, Oba A, Ono Y, Sato T, Ito H, Ozaka M, Sasaki T, Sasahira N, Baba
H, Takahashi Y: Clinical efficacy of neoadjuvant chemotherapy with Gemcitabine plus S-1 forresectable pancreatic ductal adenocarcinoma compared with upfront surgery. Ann Surg Oncol
30:5093-5102, 2023
25. Morinaga T, Iwatsuki M, Yamashita K, Yasuda-Yoshihara N, Yamane T, Matsumoto C, Harada
K, Eto K, Kurashige J, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Baba H: Dynamic alterationin HLA-E expression and soluble HLA-E via interaction with natural killer cells in gastric cancer.
Ann Surg Oncol 30:1240-1252, 2023
26. Morito A, Harada K, Iwatsuki M, Maeda Y, Mitsuura C, Toihata T, Kosumi K, Eto K, Iwagami
S, Baba Y, Miyamoto Y, Yoshida N, Baba H: Frailty Assessed by the Clinical Frailty Scale isAssociated with Prognosis After Esophagectomy. Ann Surg Oncol 30:3725-3732, 2023
27. Akiyama T, Miyamoto Y, Matsuda A, Tokunaga R, Ogawa K, Iwatsuki M, Iwagami S, Baba Y,
Yoshida N, Sonoda H, Yamada T, Yoshida H, Baba H: The colon inflammatory index score canpredict the survival outcome after resection of colorectal cancer: a retrospective multicentre study.
J Cancer Res Clin Oncol 149:7887-7894, 2023
28. Kobayashi S, Wada H, Sakai D, Baba H, Kanai M, Kamachi H, Takayama T, Ueno M, Takahashi
M, Sho M, Yoshimura K, Hatano E, Nagano H, Ioka T: Impact of tumor shrinkage pattern withbiweekly triplet gemcitabine+cisplatin+S-1 regimen for biliary tract cancers: Implications forneoadjuvant therapy from the data of KHBO1401 (KHBO1401-1A study). Oncology:1-10, 2023
29. Maeda Y, Eto K, Yoshida N, Iwatsuki M, Iwagami S, Ogawa K, Sawayama H, Baba Y, Miyamoto
Y, Baba H: The 5-factor modified frailty index is a novel predictive marker of death from otherdiseases after curative gastrectomy for gastric cancer. Geriatr Gerontol Int 23:750-756, 2023
30. Horino T, Tokunaga R, Miyamoto Y, Hiyoshi Y, Akiyama T, Daitoku N, Sakamoto Y, Yoshida N,
Baba H: The impact of the advanced lung cancer inflammation index on the outcomes of patientswith metastatic colorectal cancer who receive chemotherapy. Int J Clin Oncol 28:400-408, 2023
31. Kato R, Miyamoto Y, Ouchi M, Ogawa K, Yoshida N, Baba H: The Geriatric Nutritional Risk
Index is a prognostic marker in patients with metastatic colorectal cancer. Int J Clin Oncol
28:893-900, 2023
32. Kayashima H, Itoh S, Shimokawa M, Hayashi H, Takamori H, Fukuzawa K, Ninomiya M, Araki
K, Yamashita YI, Sugimachi K, Uchiyama H, Morine Y, Utsunomiya T, Uwagawa T, Maeda T,
Baba H, Yoshizumi T: Effect of duration of adjuvant chemotherapy with S-1 (6 versus 12 months)
for resected pancreatic cancer: the multicenter clinical randomized phase II postoperative
adjuvant chemotherapy S-1 (PACS-1) trial. Int J Clin Oncol 28:1520-1529, 2023
33. Maehara Y, Oki E, Ota M, Harimoto N, Ando K, Nakanishi R, Kawazoe T, Fujimoto Y, Nonaka
K, Kitao H, Iimori M, Makino K, Takechi T, Sagara T, Miyadera K, Matsuoka K, Tsukihara H,
Kataoka Y, Wakasa T, Ochiiwa H, Kamahori Y, Tokunaga E, Saeki H, Yoshizumi T, Kakeji Y,
Shirabe K, Baba H, Shimada M: Lineage of drug discovery research on fluorinated pyrimidines:
chronicle of the achievements accomplished by Professor Setsuro Fujii. Int J Clin Oncol 28:613624, 2023

34. Okui J, Shigeta K, Kato Y, Mizuno S, Sugiura K, Seo Y, Nakadai J, Baba H, Kikuchi H, Hirata
A, Makino A, Kondo T, Matsui S, Seishima R, Okabayashi K, Obara H, Sato Y, Kitagawa Y:
Delayed-onset organ/space surgical site infection worsens prognosis in high-risk stage II and III
colorectal cancer. J Gastrointest Surg 27:2515-2525, 2023
35. Ioka T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A, Takayama T,
Yamaue H, Takahashi M, Sho M, Kamei K, Fujimoto J, Toyoda M, Shimizu J, Goto T, Shindo Y,
Yoshimura K, Hatano E, Nagano H, Kansai Hepatobiliary Oncology G: Randomized phase III
study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract
cancer (KHBO1401- MITSUBA). J Hepatobiliary Pancreat Sci 30:102-110, 2023
36. Lan C, Yamashita YI, Tsukamoto M, Hayashi H, Nakagawa S, Liu Z, Wu X, Imai K, Mima K,
Kaida T, Baba H: The prognostic role of serine racemase in patients with pancreatic cancer: A
new marker in cancer metabolism. Pancreas 52:e101-e109, 2023
37. Kanaka S, Matsuda A, Yamada T, Miyamoto Y, Yokoyama Y, Matsumoto S, Sonoda H, Ohta R,
Shinji S, Sekiguchi K, Baba H, Yoshida H: Segmental or right hemi-colectomy? The optimal
surgical procedure for transverse colon cancer: a propensity score-matched, multicenter,retrospective study. Int J Colorectal Dis 38:58, 2023
38. Iwatsuki M, Matsumoto C, Mimori K, Baba H: The comprehensive review of gastricadenocarcinoma and proximal polyposis of the stomach (GAPPS) from diagnosis and treatment.
Ann Gastroenterol Surg 7:725-732, 2023
39. Kobayashi H, Kotake K, Kawasaki M, Kanemitsu Y, Kinugasa Y, Ueno H, Maeda K, Suto T,
Itabashi M, Funahashi K, Ozawa H, Koyama F, Noura S, Ishida H, Ohue M, Kiyomatsu T,
Ishihara S, Koda K, Baba H, Kawada K, Hashiguchi Y, Goi T, Toiyama Y, Tomita N, Sunami E,
Akagi Y, Watanabe J, Hakamada K, Nakayama G, Sugihara K, Ajioka Y: A proposed newJapanese classification of synchronous peritoneal metastases from colorectal cancer: A multiinstitutional, prospective, observational study conducted by the Japanese Society for Cancer of
the Colon and Rectum. Ann Gastroenterol Surg 7:765-771, 2023
40. Mima K, Nakagawa S, Miyata T, Yamashita YI, Baba H: Frailty and surgical outcomes ingastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgicalpractice for vulnerable patients. Ann Gastroenterol Surg 7:27-41, 2023

41. Miyamoto Y, Ogawa K, Ohuchi M, Tokunaga R, Baba H: Emerging evidence of immunotherapy
for colorectal cancer. Ann Gastroenterol Surg 7:216-224, 2023
42. Nakamura I, Hatano E, Baba H, Kamei K, Wada H, Shimizu J, Kanai M, Yoshimura K, Nagano
H, Ioka T: Impact of conversion surgery after chemotherapy in patients with initially unresectable
and recurrent biliary tract cancer. Ann Gastroenterol Surg 7:1009-1020, 2023
43. Baba Y, Hara Y, Toihata T, Kosumi K, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N,
Komohara Y, Baba H: Relationship between gut microbiome Fusobacterium nucleatum andLINE-1 methylation level in esophageal cancer. Esophagus 20:704-712, 2023
44. Yoshida N, Eto K, Horinouchi T, Shiraishi S, Kanemitsu K, Ofuchi T, Tajiri T, Adachi Y, Horino
T, Morito A, Mitsuura C, Maeda Y, Hara Y, Matsumoto C, Baba H: Prognostic value of (18)Ffluorodeoxyglucose uptake in the bone marrow on pretreatment positron emission
tomography/computed tomography in patients with esophageal cancer who underwent
esophagectomy. Esophagus 20:660-668, 2023
45. Kawata A, Miyamoto Y, Fukubayashi K, Horio T, Miyamoto H, Ogawa K, Ouchi M, Tanaka Y,
Baba H: Conversion surgery after Encorafenib plus Cetuximab for chemorefractory BRAF
V600E-mutated colorectal cancer with para-aortic lymph node metastases. In Vivo 37:1797-1801,
2023
46. Maeda Y, Iwatsuki M, Mitsuura C, Morito A, Ohuchi M, Kosumi K, Eto K, Ogawa K, Baba Y,
Iwagami S, Miyamoto Y, Yoshida N, Baba H: Textbook outcome contributes to long-term
prognosis in elderly colorectal cancer patients. Langenbecks Arch Surg 408:245, 2023
47. Morito A, Iwatsuki M, Maeda Y, Mitsuura C, Hara Y, Matsumoto C, Toihata T, Kosumi K, Eto
K, Baba Y, Iwagami S, Miyamoto Y, Yoshida N, Baba H: Textbook outcome contributes to longterm prognosis in older adults with gastric cancer. Langenbecks Arch Surg 408:324, 2023
48. Ogawa K, Shiraishi Y, Karashima R, Nitta H, Masuda T, Matsumoto K, Sawayama H, Miyamoto
Y, Baba H, Takamori H: Prolonged door-to-antibiotics time is associated with high hospitalmortality in patients with perforated colorectal peritonitis. Langenbecks Arch Surg 408:220,
2023
49. Arima K, Uemura N, Tsuneyoshi K, Fujita H, Kuroki H, Uemura S, Hanada N, Baba H,

Komohara Y: Microsatellite instability-high signet ring cell carcinoma of the colon treated withimmunotherapy: Report of a Case. Anticancer Res 43:4729-4733, 2023
50. Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T,
Yanagida E, Murayama T, Miyanari N, Baba H: Conversion surgery after Atezolizumab plus
Bevacizumab for primary and peritoneal metastasis after hepatocellular carcinoma rupture.
Anticancer Res 43:943-947, 2023
51. Tomita M, Okabe H, Masuda T, Ono A, Kuroda D, Kuroki H, Hirota M, Hibi T, Baba H, Sugita
H: A case of accessory hepatic duct entering cystic duct successfully treated by laparoscopiccholecystectomy for cholecystolithiasis. Asian J Endosc Surg 16:546-549, 2023
52. Tubakihara H, Sawayama H, Komohara Y, Miyamoto Y, Ogawa K, Ohuchi M, Yoshida N, Baba
H: A case of familial adenomatous polyposis with protein-losing enteropathy treated bylaparoscopic total colorectal resection: A literature review. Asian J Endosc Surg 16:77-81, 2023
53. Ijima H, Fukuda Y, Uehara MK, Shafiq M, Wu FQ, Cho JY, Sakai Y, Miyata T, Yamao T, Nakao
Y, Kuroda Y, Motomura T, Yamashita YI, Baba H: Decellularized mouse liver as a small-scale
scaffold for the creation of a miniaturized human liver. J Chem Eng Jpn 56, 2023
54. Horino T, Miyamoto Y, Ohuchi M, Ogawa K, Yoshida N, Ishiko T, Kukinaka C, Sasaki R, Ohba
T, Baba H: Repeated intestinal perforations in vascular Ehlers-Danlos syndrome: a case report ofa novel mutation in the COL3A1 gene. Surg Case Rep 9:78, 2023
55. Omachi K, Imai K, Nakao Y, Nakamura H, Kaida T, Shiraishi Y, Itoyama R, Nitta H, Hayashi H,
Asato T, Mikami Y, Baba H: A surgical resection of hepatic granuloma mimicking intrahepaticcholangiocarcinoma: a case report. Int Cancer Conf J 12:195-199, 2023
56. Hirao H, Okabe H, Masuda T, Ogawa D, Uemura N, Kuroda D, Taki K, Tomiyasu S, Hirota M,
Hibi T, Baba H, Sugita H: Intestinal fluid CT level could predict pathological small bowel
ischemia in small bowel obstruction. Indian J Surg 85:596-601, 2023
57. Stachler MD, Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe M, Agoston
A, Jajoo K, Davison JM, Nason K, Getz G, Wang KK, Imamura Y, Odze R, Bass AJ, Zhang CZ: Origins of cancer genome complexity revealed by haplotype-resolved genomic analysis ofevolutionofBarrett’s

esophagustoesophageal

adenocarcinoma.

bioRxiv:

2021.2003.2026.437288, 2023
58. Fujiwara N, Kubota N, Zhu S, Nakagawa S, Baba H, Hoshida Y: Disseminative recurrence
signature for hepatocellular carcinoma from nonalcoholic fatty liver disease. Gastro Hep
Advances 2:681-683, 2023
59. Wu X, Iwatsuki M, Takaki M, Saito T, Hayashi T, Kondo M, Sakai Y, Gotohda N, Tanaka E,
Nishida T, Baba H: FBXW7 regulates the sensitivity of imatinib in gastrointestinal stromal
tumors by targeting MCL1. Gastric Cancer, 2023 Dec 24. doi: 10.1007/s10120-023-01454-6.
Online ahead of print.
60. Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H: ASO Author Reflections: The
significance of IL-8 expression in cancer-associated fibroblast of gastric cancer. Ann Surg Oncol,
2023 Dec 12. doi: 10.1245/s10434-023-14660-4. Online ahead of print.
61. Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H: Cancer-associated fibroblastderived IL-8 upregulates PD-L1 expression in gastric cancer through the NF-kappaB pathway.
Ann Surg Oncol, 2023 Nov 25. doi: 10.1245/s10434-023-14586-x. Online ahead of print.
62. Takematsu T, Mima K, Hayashi H, Kitano Y, Nakagawa S, Hiyoshi Y, Okabe H, Imai K,
Miyamoto Y, Baba H: RAS mutation status in combination with the JSHBPS nomogram may be
useful for preoperative identification of colorectal liver metastases with high risk of recurrence
and mortality after hepatectomy. J Hepatobiliary Pancreat Sci, 2023 Oct 27. doi:
10.1002/jhbp.1389. Online ahead of print.
63. Morito A, Eto K, Iwatsuki M, Toihata T, Kosumi K, Iwagami S, Baba Y, Miyamoto Y, Yoshida
N, Baba H: Clinical impact of very early recurrence after conversion surgery for stage IV gastriccancer. Ann Gastroenterol Surg, Sep 14. doi: org/10.1002/ags3.12738. Online ahead of print.
64. Yonemura A, Semba T, Zhang J, Fan Y, Yasuda-Yoshihara N, Wang H, Uchihara T, Yasuda T,
Nishimura A, Fu L, Hu X, Wei F, Kitamura F, Akiyama T, Yamashita K, Eto K, Iwagami S,
Iwatsuki M, Miyamoto Y, Matsusaki K, Yamasaki J, Nagano O, Saya H, Song S, Tan P, Baba H,
Ajani JA, Ishimoto T: Mesothelial cells with mesenchymal features enhance peritoneal
dissemination by forming a protumorigenic microenvironment. Cell Rep 43:113613, 2024
65. Baba Y, Yasuda N, Bundo M, Nakachi Y, Ueda J, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida

N, Oshiumi H, Iwamoto K, Baba H: LINE-1 hypomethylation, increased retrotransposition andtumor-specific insertion in upper gastrointestinal cancer. Cancer Sci 115:247-256, 2024
66. Mima K, Hayashi H, Adachi Y, Tajiri T, Ofuchi T, Kanemitsu K, Ogawa D, Yumoto S, Matsumoto
T, Itoyama R, Kitano Y, Nakagawa S, Okabe H, Baba H: Patient vulnerability is associated withpoor prognosis following upfront hepatectomy for colorectal liver metastasis. Int J Clin Oncol
29:47-54, 2024
67. Kitano Y, Ono Y, Kobayashi K, Oba A, Sato T, Ito H, Inoue Y, Shinozaki E, Yamaguchi K, Saiura
A, Baba H, Takahashi Y: Neoadjuvant chemotherapy for borderline resectable colorectal cancer
liver metastases: a single-institution retrospective study. HPB 26:282-290, 2024
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Eto K, Ogawa K, Sawayama H, Iwatsuki M, Baba Y, Miyamoto Y, Baba H: Relationship between
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Hinokuma, H., Kanamori, Y., Ikeda, K., Hao, L., Maruno, M., Yamane, T., Maeda, A., Nita, A.,
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Hayama K, Atsukawa M, Tsubota A, Kondo C, Iwasa M, Hasegawa H, Takaguchi K, Tsutsui A,
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Matsuno K, Miyamoto H, Kitada H, Yoshimatsu S, Tamura F, Sakurai K, Fukubayashi K, Shono
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Janssen HLA, Hou J, Asselah T, Chan HLY, Zoulim F, Tanaka Y, Janczewska E, Nahass RG,
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Mizuochi T, Iwama I, Inui A, Ito Y, Takaki Y, Mushiake S, Tokuhara D, Ishige T, Ito K, Murakami
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Wong D K-H, Inoue T, Mak L-Y 1, Hui R W-H, Fung J, Cheung K-S, Seto W-K, Tanaka Y, Yuen
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Suzuki T, Matsuura K, Urakabe K, Okumura F, Kawamura H, Sobue S, Matoya S, Miyaki T,
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S, Kusumoto S, Inoue T, Tanaka Y, Kataoka H: Outcome of nucleos(t)ide analog cessation inpatients with treatment for prevention of or against hepatitis B virus reactivation.
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Huang DQ, Tran A, Yeh ML, Yasuda S, Tsai PC, Huang CF, Dai CY, Ogawa E, Ishigami M, Ito
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SX, Khine HHTW, Itokawa N, Atsukawa M, Uojima H, Watanabe T, Takahashi H, Inoue K,
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carcinoma risk in chronic Hepatitis B patients in the indeterminate phase.
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Takamatsu Y, Hayashi S, Kumamoto H, Imoto S, Tanaka Y, Mitsuya H, Higashi-Kuwata N: A
novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associatedcellular marker perturbation in human hepatocytes.
Virus Res. 329: 199094, 2023

10. Chida T, Ishida Y, Morioka S, Sugahara G, Han C, Lam B, Yamasaki C, Sugahara R, Li M,
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11. Kumamoto H, Higashi-Kuwata N, Hayashi S, Das D, Bulut H, Tokuda R, Imoto S, Onitsuka K,
Honda Y, Odanaka Y, Shimbara-Matsubayashi S, Haraguchi K, Tanaka Y, Mitsuya H: Synthesisof novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as anaglycone moiety as highly potent and long-acting anti-hepatitis B virus agent.
RSC Adv. 13: 15999-16011, 2023
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15. Fujimoto N, Nagaoka K, Tatsuno I, Oishi H, Tomita M, Hasegawa T, Tanaka Y, Matsumoto T:
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16. Kitagawa K, Kim KS, Iwamoto M, Hayashi S, Park H, Nishiyama T, Nakamura N, Fujita Y,
Nakaoka S, Aihara K, Perelson AS, Allweiss L, Dandri M, Watashi K, Tanaka Y, Iwami S.
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bioRxiv. 06.06.543822, 2023
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24. Shiraishi K, Nakaura T, Uetani H, Nagayama Y, Kidoh M, Kobayashi N, Morita K, Yamahita
Y, Tanaka Y, Baba H, Hirai T: Deep learning-based reconstruction and 3D hybrid profile ordertechnique for MRCP at 3T: evaluation of image quality and acquisition time.
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25. Yoshimaru Y, Nagaoka K, Tanaka K, Narahara S, Inada H, Kurano S, Tokunaga T, Iio E,
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Y, Tanaka Y: Randomized phase I/II study of vascular endothelial growth factor receptor
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26. Setoyama H, Nishida N, Nagashima S, Ko K, Yamazoe T, Tanaka Y, Mizokami M, Tanaka J,
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27. Suzuki T, Matsuura K, Suzuki Y, Okumura F, Nagura Y, Sobue S, Matoya S, Miyaki T, Kimura
Y, Kusakabe A, Narahara S, Tokunaga T, Nagaoka K, Kuroyanagi K, Kawamura H, Kuno K,
Fujiwara K, Nojiri S, Kataoka H, Tanaka Y: Serum CXCL10 levels at the start of the second
course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients withadvanced BCLC stage C hepatocellular carcinoma: A multicenter analysis.
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28. Waki K, Matsuno K, Miyamoto H, Gushima R, Takeda H, Orita Y, Tanaka Y. Pharyngeal
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31. Ogawa E, Jun DW, Toyoda H, Hsu YC, Yoon EL, Ahn SB, Yeh ML, Do S, Trinh HN, Takahashi
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H, Hsu YC, Tseng CH, Liu J, Chen YL, Lin PY, Jun DW, Yoshimaru Y, Ogawa E, Ishigami M,
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S, Ishikawa T, Yasuda S, Tsutsui A, Arai T, Kumada T, Tanaka Y, Tanaka J, Chayama K:
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35. Nagura Y, Suzuki T, Matsuura K, Ogawa S, Kawamura H, Kuno K, Fujiwara K, Nojiri S,
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H: Serum MYCN as a predictive biomarker of prognosis and therapeutic response in theprevention of hepatocellular carcinoma recurrence.
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Takahashi K, Hiratsuka Y, Sasaki D, Sakaue T, Enomoto D, Morioka H, Uemura S, Okura T,
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amyloidosis. Radiology, 306: e220542, 2023

3.

Goto M, Tasaki M, Ueda M. Early onset Congo red-positive fibrillary glomerulonephritis
associated with glomerular DNAJB9 deposits mimicking renal amyloidosis. Pathol Int, 73: 106108, 2023

4.

Misumi Y, Tabata Y, Tasaki M, Obayashi K, Yamakawa S, Nomura T, Ueda M. Binding of serumderived amyloid-associated proteins to amyloid fibrils. Amyloid, 30: 67-73, 2023

5.

Maeda-Ogata S, Tahara N, Tahara A, Bekki M, Honda A, Sugiyama Y, Igata S, Abe T, Sekijima
Y, Ueda M, Ando Y, Fukumoto Y. Treatment response to Tafamidis quantitatively assessed byserial bone scintigraphy in transthyretin amyloid cardiomyopathy. J Nucl Cardiol, 30: 403-404,
2023

6.

Hirai T, Abe O, Nakamura M, Inui S, Uetani H, Ueda M, Azuma M. Brain structural changes inpatients with chronic methylmercury poisoning in Minamata. Brain Res, 1805: 148278, 2023

7.

Kuyama N, Takashio S, Nagakura T, Imamura M, Takamatsu K, Takae M, Hirakawa K,
Yamanaga K, Hanatani S, Yamamoto E, Matsushita K, MD, Ueda M, Tsujita K. Anti-Kv1.4
antibody positive myocarditis and myositis despite absence of thymoma and anti-acetylcoline
receptor antibody. JACC Case Rep, 9: 101734, 2023

8.

Murakami Y, Wei F, Kawamura Y, Horiguchi H, Kadomatsu T, Miyata K, Miura K, Oike Y, Ando
Y, Ueda M, Tomizawa K, Chujo T. NSUN3-mediated mitochondrial tRNA 5-formylcytidine
modification is essential for embryonic development and respiratory complexes in mice.
Commun Biol, 6: 307, 2023

9.

Nagayama Y, Iwashita K, Maruyama N, Uetani H, Goto M, Sakabe D, Emoto T, Nakato K,
Shigematsu S, Kato Y, Takada S, Kidoh M, Oda S, Nakaura T, Hatemura M, Ueda M, Mukasa A,
Hirai T. Deep learning-based reconstruction can improve the image quality of low radiation dosehead CT. Eur Radiol, 33: 3253-3265, 2023

10. Kidoh M, Oda S, Takashio S, Kawano Y, Hayashi H, Emoto T, Shigematsu S, Yoshimura F,

Nakaura T, Nagayama Y, Matsuoka M, Ueda M, Tsujita K, Hirai T. Cardiac MRI-derived
extracellular volume fraction versus myocardium-to-lumen R1 ratio on post-contrast T1 mapping
for detecting cardiac amyloidosis. Radiol Cardiothorac Imaging, 5: e220327, 2023

11. Tahara S, Kohyama M, Nakamitsu A, Sugiyama Y, Tazaki T, Taogoshi H, Komo T, Yamaguchi T,

Ueda M, Ishikawa A, Takahashi S, Sasaki M. Surgical strategies for localized colorectal
amyloidosis. Surg Case Rep, 9:66, 2023
12. Usuku H, Yamamoto E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Oike F, Fujisue K, Hanatani

S, Arima Y, Takashio S, Kawano Y, Oda S, Kawano H, Matsushita K, Ueda M, Matsui H,
Matsuoka M, Tsujita K. Prognostic value of right ventricular global longitudinal strain in patientswith immunoglobulin light-chain cardiac amyloidosis. Eur Heart J Open, 3: oead048, 2023
13. Takahashi K, Morioka H, Sasaki D, Yamamura N, Kitazawa S, Ueda M, Sakaue T, Enomoto D,

Uemura S, Okura T, Ikeda S. Two autopsy cases of wild-type transthyretin cardiac amyloidosis
who died 10 days after technetium-99mpyrophosphate scintigraphy. J Nucl Cardiol, 30: 22152221, 2023
14. Takeuchi Y, Nomura T, Nakahara K, Ueda M. Autoimmune polyglandular syndrome withrefractory gait disturbance. Intern Med, 62: 2133-2137, 2023
15. Matsushita H, Sameshima G, Fukunari A, Okada M, Inoue F, Ueda M, Ando Y. Suppression ofamyloid fibril formation by UV irradiation. Journal of Radiation Research and Applied Sciences,
15: 1-6, 2023
16. Naiki H, Yamaguchi A, Sekijima Y, Ueda M, Ohashi K, Hatakeyama K, Ikeda Y, Hoshii Y,

Shintani-Domoto Y, Miyagawa-Hayashino A, Tsujikawa H, Endo J, Arai T, Ando Y. Steep
increase in the number of transthyretin-positive cardiac biopsy cases in Japan: evidence obtainedby the nation-wide pathology consultation for the typing diagnosis of amyloidosis. Amyloid, 30:
321-326, 2023
17. Yamashita S, Nagatoshi A, Takeuchi Y, Nishino I, Ueda M. Myopathic changes caused by protein

aggregates in adult-onset spinal muscular atrophy. Neuropathology, 43: 408-412, 2023
18. Takashio S, Morioka M, Ishii M, Morikawa K, Hirakawa K, Hanatani S, Oike F, Usuku H, Kidoh

M, Oda S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Clinical characteristics, outcome, andtherapeutic effect of tafamidis in wild-type transthyretin amyloid cardiomyopathy. ESC Heart
Fail, 10: 2319-2329, 2023

19. Takashio S, Kato T, Tashima H, Irie H, Komohara Y, Oguni T, Morikawa K, Kuyama N, Tabata

N, Hanatani S, Yamamoto E, Matsushita K, Ueda M, Tsujita K. Prevalence of cardiac amyloidosis
in patients undergoing carpal tunnel release with amyloid deposition. Circ J, 87: 1047-1055, 2023
20. Nomura T, Fujiki F, Ueda M. Popeye’s sign in hereditary transthyretin amyloidosis. JAMA

Neurol, 80: 998-999, 2023
21. Usuku H, Yamamoto E, Imamura K, Fujisaki T, Egashira K, Komorita T, Oike F, Ishii M, Fujisue

K, Hanatani S, Sueta D, Arima Y, Takashio S, Oda S, Kawano H, Matsushita K, Ueda M, Matsui
H, Tsujita K. Usefulness of automatic assessment of longitudinal strain to diagnose transthyretin
amyloid cardiomyopathy. Int J Cardiol Heart Vasc, 47: 101227, 2023
22. Kido J, Egami K, Misumi Y, Sugawara K, Tsuchida N, Matsumoto N, Ueda M, Nakamura K. X-

linked intellectual disability related to a novel variant of KLHL15. Hum Genome Var, 10:21,
2023
23. Yamashita S, Tawara N, Hara K, Ueda M. Gender differences in clinical features at the initial

examination of late-onset amyotrophic lateral sclerosis. J Neurol Sci, 451: 120697, 2023
24. Namitome S, Uchida K, Shindo S, Yoshimura S, Sakai N, Yamagami H, Toyoda K, Matsumaru

Y, Matsumoto Y, Kimura K, Ishikura R, Inoue M, Beppu M, Sakakibara F, Shirakawa M, Ueda
M, Morimoro T, for the RESCUE-Japan LIMIT Investigators. Number of passes of endovasculartherapy for stroke with a large ischemic core: Secondary analysis of RESCUE-Japan LIMIT.
Stroke, 54: 1985-1992, 2023
25. Kutsuzawa N, Takiguchi H, Ikoma H, Kumaki N, Nagai T, Ueda M, Ono Y, Horio Y, Niimi K,

Hayama N, Ito Y, Oguma T, Asano K. Nodular pulmonary amyloidosis preceding gastric mucosaassociated lymphoid tissue lymphoma, initially suspected to be lung cancer. Tokai J Exp Clin
Med, 48: 91-94, 2023
26. Ticau S, Aldinc E, Polydefkis M, Adams D, Coelho T, Ueda M, Hale C, Vest J, Nioi P, Patisiran

Global OLE study group. Treatment response and neurofilament light chain levels with long-term
patisiran in hereditary transthyretin-mediated amyloidosis with polyneuropathy: 24 months
results of an open-label extension study. Amyloid, 2023 (in press)
27. Hayashi H, Oda S, Kidoh M, Yamaguchi S, Yoshimura F, Takashio S, Usuku H, Nagayama Y,

Nakaura T, Ueda M, Tsujita K, Hirai T. Myocardial extracellular volume quantification in cardiac
amyloidosis: Comparison with cardiac computed tomography and magnetic resonance imaging.
Eur Radiol, 2023 (in press)
28. Ohe M, Tahara N, Ueda M, Fukumoto Y. P-wave characteristics and atrium voltage mapping in

cardiac amyloidosis with paroxysmal atrial fibrillation. Eur Heart J Case Rep, 7: ytad319, 2023
29. Takahashi K, Hiratsuka Y, Iwamura T, Sasaki D, Yamamura N, Kitazawa S, Ueda M, Morioka H,

Okura T, Enomoto D, Uemura S, Kono T, Sakaue T, Ikeda S. Technetium-99m-pyrophosphate
imaging-based computed tomography-guided core-needle biopsy of internal oblique muscle inwild-type transthyretin cardiac amyloidosis. Amyloid, 2023 (in press)
30. Noda Y, Kido J, Misumi M, Sugawara K, Itai T, Miyatake S, Matsumoto N, Ueda M, Nakamura

K. A case of PURA syndrome with severe developmental delay harboring c.175C>T variant. Clin
Case Rep, 11: e7779, 2023
31. Matsuo K, Nakaura T, Morita K, Uetani H, Nagayama Y, Kidoh M, Hokamura M, Yamashita Y,

Shinoda K, Ueda M, Mukasa A, Hirai T. Feasibility study of super-resolution deep learning-based
reconstruction using k-space properties in brain diffusion weighted images. Neuroradiology, 65:
1619-1629, 2023
32. Ikenoshita S, Matsuo K, Yabuki Y, Kawakubo K, Asamitsu S, Hori K, Usuki S, Hirose Y, Bando

T, Araki K, Ueda M, Sugiyama H, Shioda N. A cyclic pyrrole-imidazole polyamide reduces
pathogenic RNA in CAG/CTG triplet repeat neurological disease models. J Clin Invest, 133:
e164792, 2023
33. Takahashi K, Iwamura T, Hiratsuka Y, Sasaki D, Yamamura N, Ueda M, Morioka H, Yoshino M,

Enomoto D, Uemura S, Okura T, Sakaue T, Ikeda S. A Gluteus Medius Muscle Biopsy to Confirm
Amyloid Transthyretin Deposition in Wild-type Transthyretin Cardiac Amyloidosis: A Report of
Two Cases. Intern Med, 2023 (in press)
34. Shindo S, Uchida K, Yoshimura S, Sakai N, Yamagami H, Toyoda K, Matsumaru Y, Matsumoto

Y, Kimura K, Ishikura R, Inoue M, Sakakibara F, Nakajima M, Ueda M, Morimoto T. Intravenous
alteplase before endovascular therapy for acute large vessel occlusion with large ischemic core:subanalysis of a randomized clinical trial. J Neurointerv Surg, 2023 (in press)
35. Maeda K, Sugimoto K, Tasaki M, Taniwaki T, Arima T, Shibata Y, Tateyama M, Karasugi T,

Sueyoshi T, Masuda T, Uehara Y, Tokunaga T, Hisanaga S, Yugami M, Yonemitsu R, Ideo K,
Matsushita K, Fukuma Y, Uragami M, Kawakami J, Yoshimura N, Takata K, Shimada M,
Tanimura S, Matsunaga H, Kai Y, Takata S, Kubo R, Tajiri R, Homma F, Tian X, Ueda M,
Nakamura T, Miyamoto T. Transthyretin amyloid deposition in ligamentum flavum (LF) issignificantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal
stenosis. Sci Rep, 13: 20019, 2023
36. Takahashi K, Iwamura T, Hiratsuka Y, Sasaki D, Yamamura N, Ueda M, Yoshino M, Enomoto D,

Morioka H, Uemura S, Okura T, Sakaue T, Ikeda S. Iatrogenic intramuscular hematoma of theoblique muscles as a complication of technetium-99m-labeled pyrophosphate imaging-based
computed tomography-guided core-needle biopsy in a patient with wild-type transthyretin
cardiac amyloidosis. Radiol Case Rep, 19; 330-340, 2023
37. Masuda T, Misumi Y, Nomura T, Yamakawa S, Tasaki M, Obayashi K, Ando Y, Ueda M.

Correlation between a commercial electrophysiological test of sudomotor function andintraepidermal nerve fiber density in hereditary transthyretin amyloidosis. Muscle Nerve, 69: 99102, 2024
38. Ueda M, Misumi Y, Nomura T, Tasaki M, Yamakawa S, Obayashi K, Yamashita T, Ando Y.

Disease-modifying drugs extend survival in hereditary transthyretin amyloid polyneuropathy.
Ann Neurol, 2023 (in press)
39. Yamaguchi A, Tasaki M, Ueda M, Ando Y, Naiki H. Epidemiological study of the subtype

frequency of systemic amyloidosis listed in the Annual of the Pathological Autopsy Cases inJapan. Pathol Int, 2023 (in press)
40. Nishizawa RH, Kawano H, Yoshimuta T, Eguchi C, Kojima S, Minami T, Sato D, Eguchi M,

Okano S, Ikeda S, Ueda M, Maemura K. Effects of tafamidis on the left ventricular and left atrial
strain in patients with wild-type transthyretin cardiac amyloidosis. Eur Heart J Cardiovasc
Imaging, 2023 (in press)
41. Watanabe T, Takihara Y, Jono H, Fujimoto T, Tasaki M, Isoguchi A, Urahashi Y, Shimoda T,

Takahashi E, Ando Y, Ueno S, Ueda M, Inoue T. Silencing of ocular transthyretin, a gene
responsible for hereditary transthyretin amyloidosis, by intravitreal injection of an siRNA
conjugate into rabbit eyes. Biochem Biophys Res Commun, 694:149397, 2024

42. Harada S, Azuma T, Misumi Y, Hayashi H, Matsubara S, Nakahara K, Miyatake S, Matsumoto

N, Ueda M. Novel genotype and phenotype of VPS13D-related disorders with parkinsonism
Intern Med, 2024 (in press)
43. Nomura T, Misumi Y, Tasaki M, Obayashi K, Yamashita T, Ando Y, Ueda M. Origin oftransthyretin in cerebral amyloid angiopathy. JAMA Neurol, 2024 (in press)
44. Hokamura M, Uetani H, Nakaura T, Matsuo K, Morita K, Nagayama Y, Kidoh M, Yamashita Y,

Ueda M, Mukasa A, Hirai T. Exploring the impact of super-resolution deep learning on MR
angiography image quality. Neuroradiology, 2024 (in press)
45. Ouchi K, Isono K, Ohya Y, Shiraki N, Tasaki M, Inomata Y, Ueda M, Era T, Kume S, Ando Y,

Jono H. Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced
pluripotent stem cells. Heliyon, 2024 (in press)
46. Ando Y, Waddington-Cruz M, Sekijima Y, Koike H, Ueda M, Konishi H, Ishii T, Coelho T.

Optimal practices for the management of hereditary transthyretin amyloidosis: real-world
experience from Japan, Brazil, and Portugal. Orphanet J Rare Dis, 18:323, 2023
47. Brito D, Albrecht FC, de Arenaza DP, Bart N, Better N, Carvajal-Juarez I, Conceição I, Damy T,

Dorbala S, Fidalgo J-C, Garcia-Pavia P, Ge J, Gillmore JD, Grzybowski J, Obici L, Piñero D,
Rapezzi C, Ueda M, Pinto FJ. World Heart Federation Consensus on Transthyretin Amyloidosis
Cardiomyopathy (ATTR-CM). Glob Heart, 18: 59, 2023

14）分子生理学講座
1.

Ahmad, R.N.R., Zhang, L.T., Morita, R., Tani, H., Wu, Y., Chujo, T., Ogawa, A., Harada, R.,
Shigeta, Y., Tomizawa, K., and Wei FY. Pathological mutations promote proteolysis of
mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic
peptidase (CLPP). Nucleic Acids Res. 2023 Dec 19: gkad1197.

2.

Kaneko, H., Kaitsuka, T., and Tomizawa, K. Artificial induction of circadian rhythm bycombining exogenous BMAL1 expression and polycomb repressive complex 2 inhibition inhuman induced pluripotent stem cells. Cell Mol Life Sci. 80(8), 200, 2023.

3.

Kawamura, Y., Oka, K., Semba, T., Takamori, M., Sugiura, Y., Yamasaki, R., Suzuki, Y., Chujo,T., Nagase, M., Oiwa, Y., Fujioka, S., Homma, S., Yamamura, Y., Miyawaki, S., Narita, M.,

Fukuda, T., Sakai, Y., Ishimoto, T., Tomizawa, K., Suematsu, M., Yamamoto, T., Bono, H.,
Okano, H., and Miura K. Cellular senescence induction leads to progressive cell death via the
INK4a-RB pathway in naked mole-rats. EMBO J., e111133, 2023.

4.

Miwa, T., Katsuno, T., Wei, F.-Y., and Tomizawa, K. Mitochondrial alterations in the cochleaof Cdk5rap1-knockout mice with age-related hearing loss. FEBS Open Bio. 13(7), 1365-1374,
2023.

5.

Murakami, Y., Wei, F.-Y., Kawamura, Y., Horiguchi, H., Kadomatsu, T., Miyata, K., Miura, K.,
Oike, Y., Ando, Y., Ueda, M., Tomizawa, K., and Chujo, T. NSUN3-mediated mitochondrialtRNA 5-formylcytidine modification is essential for embryonic development and respiratorycomplexes in mice. Commun. Biol. 6(1), 307, 2023.

6.

Huang, R., Yamamoto, T., Nakata, E., Ozaki, T., Kurozumi, K., Wie, F.-Y., Tomizawa, K., andFujimura, A. CDKAL1 drives the maintenance of cancer stem-like cells by assembling theeIF4F translation initiation complex. Adv. Sci., e2206542, 2023.

15）知覚生理学講座
1.

Takemoto M, Kato S, Kobayashi K, Song W-J: Dissection of insular cortex layer 5 reveals two
sublayers with opposing modulatory roles in appetitive drinking behavior.iScience 26: 106985,
2023

2.

Tomioka R, Takemoto M, Song W-J: Neurochemical properties for defining subdivisions of themedial geniculate body.Hearing Research 431: 108724, 2023

3.

Zhou B, Tomioka R, Song W-J: Temporal profiles of neuronal responses to repeated tone stimuli
in the mouse primary auditory cortex.Hearing Research 430: 108710, 2023

16）分子脳科学講座
1.

Du J, Nakachi Y, Murata Y, Kiyota E, Kato T, Bundo M, Iwamoto K: Exploration of cell-typespecific somatic mutations in schizophrenia and the impact of maternal immune activation on thesomatic mutation profile in the brain. Psychiatry and Clinical Neurosciences, in press

2.

Baba Y, Yasuda N, Bundo M, Nakachi Y, Ueda J, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida
N, Oshiumi H, Iwamoto K, Baba H: LINE-1 hypomethylation, increased retrotransposition andtumor-specific insertion in upper gastrointestinal cancer. Cancer Science 00:1-10, 2023

3.

Sugawara H, Date A, Fuke S, Nakachi Y, Kato T, Narita M, Bundo M, Iwamoto K: Quantificationof cytosine modifications in the aged mouse brain. Neuropsychopharmacology Reports, 00:1–6,
2023

4.

Fujii S, Murata Y, Imamura Y, Nakachi Y, Bundo M, Kubota-Sakashita M, Kato T, Iwamoto
K.Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation
mouse model without segment filamentous bacteria.Neuroscience Letters, 814:137467, 2023

5.

Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S,
Uezono Y, Aoki J, Takebayashi M: G protein-biased LPAR1 agonism of prototypic
antidepressants:

Implication

in

the

identification

of

novel

therapeutictargetfordepressionNeuropsychopharmacology, in press

6.

Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, Yamashita K, Semba
T, Arima K, Uchihara T, Nishimurav K, Bu L, Fu L, Wei F, Zhang J, Tong Y, Wang H, Iwamoto
K, Fukuda T, Nakagawa H, Taniguchi K, Miyamoto Y, Baba H, Ishimoto T: Downregulation of
15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion. JHEP
Reports, 5:100892, 2023

7.

Watanabe R, Nakachi Y, Matsubara H, Ueda J, Ishii T, Ukai W, Hashimoto E, Kasai K, Simizu S,
Kato T, Bundo M, Iwamoto K: Identification of epigenetically active L1 promoters in the humanbrain and their relationship with psychiatric disorders. Neuroscience Research, 195: 37-51, 2023

8.

Yu Z, Ueno K, Funayama R, Sakai M, Nariai N, Kojima K, Kikuchi Y, Li Z, Ono C, Kanatani J,
Ono J, Iwamoto K, Hashimoto K, Kinoshita K, Nakayama K, Nagasaki M, Tomita H: SexSpecific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in
Schizophrenia. Molecular Neurobiology 60:1083-1098, 2023

9.

Inoue H, Hirasaki M, Kogashiwa Y, Nakachi Y, Kuba K, Ebihara Y, Nakahira M, Yasuda M,
Okuda A, Sugasawa M: Identification of novel oncogenes in oral cancer among elderly
nonsmokers. Clinical and Experimental Dental Research 9: 711-720, 2023

17）眼科学講座
1.

Murata N, Takahashi E, Saruwatari J, Kojima S, Inoue T: Outcomes and risk factors for ab interno
trabeculotomy with a Kahook dual blade. Graefes Arch Clin Exp Ophthalmol 261: 503-511,

2023.

2.

Asaoka R, Sugisaki K, Inoue T, Yoshikawa K, Kanamori A, Yamazaki Y, Ishikawa S, Uchida K,
Iwase A, Araie M; for Advanced Glaucoma Study Members in Japan Glaucoma Society:
Identifying central 10° visual subfield associated with future worsening of visual acuity in eyeswith advanced glaucoma. Br J Ophthalmol 108: 71-77, 2023.

3.

Funagura N, Fukushima S, Inoue T: Ipilimumab-related uveitis and refractory hypotony with aflat chamber in a trabeculectomized eye with exfoliation glaucoma: A case report. Am J
Ophthalmol Case Rep 29: 101807, 2023.

4.

Kiuchi Y, Inoue T, Shoji N, Nakamura M, Tanito M; Glaucoma Guideline Preparation Committee,
Japan Glaucoma Society: The Japan Glaucoma Society guidelines for glaucoma 5th edition. Jpn
J Ophthalmol 67: 189-254, 2023.

5.

Manako K, Takahashi E, Saruwatari J, Matsumura T, Kojima S, Inoue T: Risk factors for
Baerveldt glaucoma drainage implantation for uveitic glaucoma. Sci Rep 13: 4473, 2023.

6.

Fujimoto T, Inoue-Mochita M, Inoue T: A ROCK inhibitor suppresses the transforming growth
factor-beta-2-induced endothelial– mesenchymal transition in Schlemm’s canal endothelial cells.
Sci Rep 13: 9655, 2023.

7.

Inatani M, Orii Y, Iwasaki K, Arimura S, Sunagawa H, Shiokawa M, Inoue K, Sakono T, Sakono
T, Kuwamura R, Yoshida A, Oi J, Kuwayama Y, Kano K, Kido N, Matsuyama A, Ozaki M, Abe
H, Inoue C, Nakagawa S, Musashi K, Kanamori A, Lee J, Otani S, Aoki R, Tanabe H, Nakakura
S, Suzuki K, Sagara T, Saito Y, Sameshima M, Urahashi M, Watanabe-Kitamura F, Inoue T,
Kagaya F, Murai Y, Mori S, Ueda K, Kurimoto T, Yamada-Nakanishi Y, Nakamura M, Yamashita
T, Ishiyama S, Manabe S, Takaki K, Hayashi K, Ishida A, Tsutsui A, Manabe K, Tanito M:
Randomized Multicenter Clinical Trial Comparing 0.1% Brimonidine/0.5% Timolol Versus 1%
Dorzolamide/0.5% Timolol as Adjuncts to Prostaglandin Analogues: Aibeta Crossover Study.
Adv Ther 40: 4074-4092, 2023.

8.

Sakata R, Araie M, Yoshitomi T; for lower normal pressure glaucoma study members in Japan
Glaucoma Society: Factors associated with visual field or structure progression occurring first in
a prospective study on patients with untreated open-angle glaucoma with normal intraocularpressure. Eye, in press.

9.

Obaru C, Kimura T, Yamamura M, Kuriyama H, Kashiwada-Nakamura K, Mizuhashi S,
Matsumura T, Watanabe T, Inoue T, Fukushima S: A case of melanoma complicated with uveitis
induced by two types of BRAF/MEK inhibitors and nivolumab treatment. J Dermatol, in press

10. Irie A, Nakashima KI, Inoue T, Kojima S, Takihara Y, Takahashi E: Trabeculotomy using the

Kahook Dual Blade for exfoliation glaucoma and primary open-angle glaucoma: Comparison ofoutcomes according to incision range. J Glaucoma, in press.
11. Watanabe T, Takihara Y, Jono H, Fujimoto T, Tasaki M, Isoguchi A, Urahashi Y, Shimoda T,

Takahashi E, Ando Y, Ueno S, Ueda M, Inoue T: Silencing of ocular transthyretin, a responsible
gene for hereditary transthyretin amyloidosis, by intravitreal injection of siRNA into rabbit eyes.
Biochem Biophys Res Commun, in press.
12. Asaoka R, Sugisaki K, Inoue T, Yoshikawa K, Kanamori A, Yamazaki Y, Ishikawa S, Uchida K,

Iwase A, Araie M: Predicting the extent of damage in the Humphrey Field Analyzer 24-2 visual
fields using 10-2 test results in patients with advanced glaucoma. Transl Vis Sci Technol, in press.

18）整形外科学講座
1. Watanabe K, Lu X, Masuda S, Miyamoto T, Katoh T: Relationship between physical activity andlocomotive syndrome among young and middle-aged Japanese workers.
J Occup Health:uiae001, 2024
2. Okamoto N, Nakamura E, Masuda T, Hisanaga S, Miyamoto T: Lateral Laxity in Flexion
Influences Patient-Reported Outcome After Total Knee Arthroplasty.
Indian J Orthop 58:24-29, 2023
3. Arima T, Sugimoto K, Taniwaki T, Maeda K, Shibata Y, Tateyama M, Karasugi T, Tokunaga T,
Sueyoshi T, Hisanaga S, Masuda T, Uehara Y, Yugami M, Matsushita K, Yonemitsu R, Kawakami
J, Yoshimura N, Tanimura S, Kato H, Ito N, Inoue K, Bando K, Nakamura T, Miyamoto T:
Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase
1 in mice.
J Biol Chem 300:105512, 2023
4. Yoshimura N, Kariya R, Shimada M, Tateyama M, Matsunaga H, Shibata Y, Tanimura S, Takata
K, Arima T, Kawakami J, Maeda K, Fukuma Y, Uragami M, Ideo K, Sugimoto K, Yonemitsu R,
Matsushita K, Hisanaga S, Yugami M, Uehara Y, Masuda T, Nakamura T, Tokunaga T, Karasugi

T, Sueyoshi T, Sato H, Iwakura Y, Araki K, Kobayashi E, Okada S, Miyamoto T: The IL-17-IL17RA axis is required to promote osteosarcoma progression in mice. Sci Rep 13:2157, 2023
5. Uragami M, Matsushita K, Shibata Y, Takata S, Karasugi T, Sueyoshi T, Masuda T, Nakamura T,
Tokunaga T, Hisanaga S, Yugami M, Sugimoto K, Yonemitsu R, Ideo K, Fukuma Y, Takata K,
Arima T, Kawakami J, Maeda K, Yoshimura N, Matsunaga H, Kai Y, Tanimura S, Shimada M,
Tateyama M, Miyamoto K, Kubo R, Tajiri R, Tian X, Homma F, Morinaga J, Yamanouchi Y,
Takebayashi M, Kajitani N, Uehara Y; Kumamoto Stop OsteoPorotic Hip Fractures (K-STOP)
Group; Miyamoto T: A machine learning-based scoring system and ten factors associated with hip
fracture occurrence in the elderly. Bone 176:116865, 2023
6. Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T,
Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H,
Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y: Spatial heterogeneity of bone marrow
endothelial cells unveils a distinct subtype in the epiphysis. Nat Cell Biol 25:1415-1425, 2023
7. Igarashi H, Nishizawa S, Miyamoto T, Hikita A, Hoshi K: Involvement of Impaired Angiogenesis
and Myelosuppression in Antiresorptive-agent Related Osteonecrosis of the Jaw Mouse Model.
Tokai J Exp Clin Med 48:22-31, 2023
8. Koike Y, Takahata M, Nakajima M, Otomo N, Suetsugu H, Liu X, Endo T, Imagama S, Kobayashi
K, Kaito T, Kato S, Kawaguchi Y, Kanayama M, Sakai H, Tsuji T, Miyamoto T, Inose H, Yoshii
T, Kashii M, Nakashima H, Ando K, Taniguchi Y, Takeuchi K, Ito S, Tomizuka K, Hikino K,
Iwasaki Y, Kamatani Y, Maeda S, Nakajima H, Mori K, Seichi A, Fujibayashi S, Kanchiku T,
Watanabe K, Tanaka T, Kida K, Kobayashi S, Takahashi M, Yamada K, Takuwa H, Lu HF, Niida
S, Ozaki K, Momozawa Y; Genetic Study Group of Investigation Committee on Ossification of
the Spinal Ligaments; Yamazaki M, Okawa A, Matsumoto M, Iwasaki N, Terao C, Ikegawa S:
Genetic insights into ossification of the posterior longitudinal ligament of the spine.Elife
12:e86514, 2023
9. Fukuma Y, Tokunaga T, Tanimura S, Yoshimoto Y, Mashimo T, Kaneko T, Tian X,

Ideo

K, Yonemitsu R, Matsushita K, Sugimoto K, Yugami M, Hisanaga S, Nakamura T, Uehara Y,
Masuda T, Shukunami C, Karasugi T, Miyamoto T:Potential function of Scx+/Sox9+ cells asprogenitor cells in rotator cuff tear repair in rats.
Biochem Biophys Res Commun 676: 84-90, 2023

10. Maeda K, Sugimoto K, Tasaki M, Taniwaki T, Arima T, Shibata Y, Tateyama M,
Karasugi T, Sueyoshi T, Masuda T, Uehara Y, Tokunaga T, Hisanaga S, Yugami M,

Yonemitsu

R, Ideo K, Matsushita K, Fukuma Y, Uragami M, Kawakami J, Yoshimura N, Takata K, Shimada
M, Tanimura S, Matsunaga H, Kai Y, Takata S, Kubo R, Tajiri R, Homma F, Tian X, Ueda M,
Nakamura T, Miyamoto T: Transthyretin amyloid deposition in ligamentum flavum (LF) issignificantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal
stenosis. Sci Rep 13:20019, 2023
11. Kawakami J, Hisanaga S, Yoshimoto Y, Mashimo T, Kaneko T, Yoshimura N, Shimada M,
Tateyama M, Matsunaga H, Shibata Y, Tanimura S, Takata K, Arima T, Maeda K, Fukuma Y,
Uragami M, Ideo K, Sugimoto K, Yonemitsu R, Matsushita K, Yugami M, Uehara Y, Nakamura
T, Tokunaga T, Karasugi T, Sueyoshi T, Shukunami C, Okamoto N, Masuda T, Miyamoto T:
Remnant tissue enhances early postoperative biomechanical strength and infiltration of Scleraxispositive cells within the grafted tendon in a rat anterior cruciate ligament reconstruction model.
PLoS One 18:e0293944, 2023
12. Shiraishi K, Nakaura T, Uetani H, Nagayama Y, Kidoh M, Kobayashi N, Morita K, Yamahita Y,
Miyamoto T, Hirai T: Combination Use of Compressed Sensing and Deep Learning for Shoulder
Magnetic Resonance Imaging With Various Sequences.
J Comput Assist Tomogr 47:277-283, 2023
13. Kushima Y, Sato Y, Kobayashi T, Fukuma Y, Matsumoto M, Nakamura M, Iwamoto T, Miyamoto
T: TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in
mice.J Bone Miner Metab 41:583-591, 2023
14. Ito E, Sato Y, Kobayashi T, Soma T, Matsumoto T, Kimura A, Miyamoto K, Matsumoto H,
Matsumoto M, Nakamura M, Sato K, Miyamoto T: Low energy availability reduces bone mass
and gonadal function in male mice. J Bone Miner Metab 41:182-192, 2023
15. Hata R, Miyamoto K, Abe Y, Sasaki T, Oguma Y, Tajima T, Arai Y, Matsumoto M, Nakamura M,
Kanaji A, Miyamoto T: Osteoporosis and sarcopenia are associated with each other and reduced
IGF1 levels are a risk for both diseases in the very old elderly. Bone 166:116570, 2023
16. Nakagawa M, Nakaura T, Yoshida N, Azuma M, Uetani H, Nagayama Y, Kidoh M, Miyamoto T,
Yamashita Y, Hirai T: Performance of Machine Learning Methods Based on Multi-Sequence
Textural Parameters Using Magnetic Resonance Imaging and Clinical Information to Differentiate

Malignant and Benign Soft Tissue Tumors.
Acad Radiol 30:83-92, 2023
17. Tamura T, Tokunaga T, Karasugi T, Miyamoto T, Kikukawa K: The remaining teres minor andsubscapularis may contribute to preventing superior migration of the humeral head andprogression of osteoarthritic change in rotator cuff tears. JSES Int 7:561-567, 2023
18. Tokunaga T, Karasugi T, Tanimura S, Miyamoto T: Association of Severe Histological
Degeneration of the Torn Supraspinatus Tendon and Retear After Arthroscopic Repair of FullThickness Rotator Cuff Tears Using the Suture Bridge Technique.
Am J Sports Med 51:2411-2421, 2023

19）筋発生再生分野
1. Ortuste Quiroga HP, Fujimaki S, Ono Y. Pax7 reporter mouse models: a pocket guide for satellite
cell research. Eur J Transl Myol. 2023 Dec 18;33(4).
2. Tanimoto A, Yamaguchi Y, Kadowaki T, Sakai E, Oyakawa S, Ono Y, Yoshida N, Tsukuba T.
Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport andmTORC1 signaling. J Cell Biochem. 2023 Aug 11. Online ahead of print. doi: 10.1002/jcb.30457.
3. Oyakawa S, Yamaguchi Y, Kadowaki T, Sakai E, Noguromi M, Tanimoto A, Ono Y, Murata H,
Tsukuba T, Tsukuba. Rab44 deficiency accelerates recovery from muscle damages by regulating
mTORC1 signaling and transport of fusogenic regulator. J Cell Physiol. 2023 Aug 10. Online
ahead of print. doi: 10.1002/jcp.31082.
4. Fujita R, Mizuno S, Sadahiro T, Hayashi T, Sugasawa T, Sugiyama F, Ono Y, Takahashi S, Ieda
M. Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics andheterogeneity. iScience. 2023 May 19;26(5): 106592.
5. Fujimaki S, Ono Y. Murine models of tenotomy-induced mechanical overloading and tailsuspension-induced mechanical unloading. Methods Mol Biol. 2023 Mar 30; 2640:207-215.
6. Araki H, Hino S*, Anan K, Kuribayashi K, Etoh K, Seko D, Takase R, Kohrogi K, Hino Y, Ono
Y, Araki E, Nakao M*. LSD1 defines the fiber type-selective responsiveness to environmental
stress in skeletal muscle. Elife. 2023 Jan 25;12:e84618.

20）中枢性代謝制御学講座
1.

Abe, T., Toda, C. Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice.
J. Vis. Exp. (203), e65581, doi:10.3791/65581 (2024).

〇老化モデル研究部門
21）老化・健康長寿学講座
1.

Yamakawa M*, Miura K (co-last author), and Kutsukake N. Helping syndrome is partiallyconfirmed in the eusocial naked mole-rat.Animal Behavior. in press

2.

Kawamura Y*, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T,
Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai
Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K*.Cellularsenescence induction leads to progressive cell death via the INK4a-RB pathway in naked molerats. The EMBO Journal 42(16):e111133, 2023

22）生命資源研究・支援センター
1.

疾患モデル分野

Noda T, Taira A, Shinohara H, Araki, K: The testis-, epididymis-, or seminal vesicle-enrichedgenes Aldoart2, Serpina16, Aoc1l3, and Pate14 are not essential for male fertility in mice. Exp
Anim 72: 314-323, 2023.

2.

Kawano S, Arak, K, Bai J, Furukawa ., Tateishi K, Yoshinobu K, Usuki S, Nimmo RA, Kaname
T, Yoshihara M, Takahashi S, Sashida G, Araki M: A gain-of-function mutation in micro-RNA142 is sufficient to cause the development of T-cell leukemia in mice. Cancer Sci 114: 28212834, 2023.

3.

Kadomatsu T, Hara C, Kurahashi R, Horiguchi H, Morinaga J, Miyata K, Kurano S, Kanemaru
H, Fukushima S, Araki K, Baba M, Linehan WM, Kamba T, Oike, Y: ANGPTL2-mediatedepigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion. Mol.
Oncol.17: 2637-2658, 2023.

4.

Nagai T, Sekimoto T, Kurogi S, Ohta T, Miyazaki S, Yamaguchi Y, Tajima T, Chosa E, Imasaka
M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Sato K, Hishikawa Y, Funamoto, T:
Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Sci.
Rep. 13: 14639, 2023.

5.

Hiyoshi N, Enomoto T, Uefune F, Kato Y, Wu Y, Araki K, Sakano D, Shiraki N, Kume, S: A

specific plasma amino acid profile in the Insulin2(Q104del) Kuma mice at the diabetic state
and reversal from hyperglycemia. Biochem Biophys Res Commun 679: 58-65, 2023.

6.

Ikenoshita S, Matsuo K, Yabuki Y, Kawakubo K, Asamitsu S, Hori K, Usuki S, Hirose Y, Bando
T, Araki K, Ueda M, Sugiyama H, Shioda, N: A cyclic pyrrole-imidazole polyamide reduces
pathogenic RNA in CAG/CTG triplet repeat neurological disease models. J Clin Invest. 133:
e164792, 2023.

7.

Tsuchiya Y, Seki T, Kobayashi K, Komazawa-Sakon S, Shichino S, Nishina T, Fukuhara K,
Ikejima K, Nagai H, Igarashi Y, Ueha S, Oikawa A, Tsurusaki S, Yamazaki S, Nishiyama C,
Mikami T, Yagita H, Okumura K, Kido T, Miyajima A, Matsushima K, Imasaka M, Araki K,
Imamura T, Ohmuraya M, Tanaka M, Nakano, H: Fibroblast growth factor 18 stimulates theproliferation of hepatic stellate cells, thereby inducing liver fibrosis. Nat Commun. 14: 6304,
202.3

8.

Shimada R, Kato Y, Takeda N, Fujimura S, Yasunaga KI, Usuki S, Niwa H, Araki K., Ishiguro
KI: STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
Nat Commun 14: 6443, 2023.

9.

Yoshimura N, Kariya R, Shimada M, Tateyama M, Matsunaga H, Shibata Y. Tanimura S, Takat,
K, Arima T, Kawakami J, Maeda K, Fukuma Y, Uragami M, Ideo K, Sugimoto K, Yonemitsu R,
Matsushita K, Hisanaga S, Yugami M, Uehara Y, Masuda T, Nakamura T, Tokunaga T, Karasugi
T, Sueyoshi T, Sato H, Iwakura Y, Araki K, Kobayashi E, Okada S, Miyamoto T: The IL-17-IL17RA axis is required to promote osteosarcoma progression in mice. Sci Rep. 13: 21572, 2023.

10. Yoshimoto R, Nakayama Y, Nomura I, Yamamoto I, Nakagawa Y, Tanaka S, Kurihara M, Suzuki
Y, Kobayashi T, Kozuka-Hata H, Oyama M, Mito M, Iwasaki S, Yamazaki T, Hirose T, Araki K,
Nakagawa S: 4.5SH RNA counteracts deleterious exonization of SINE B1 in mice. Mol Cell 83:
4479-4493 e6, 2023.
11. Zhu X, Joo Y, Bossi S, McDevitt R, Xie A, Wang Y, Xue Y, Su S, Lee SK, Sah N, Zhang S, Ye
R, Pinto A, Zhan, Y, Araki K, Araki M, Morales M, Mattson M, van Praag H, Wang W: Tdrd3null mice show post-transcriptional and behavioral impairments associated with neurogenesis
and synaptic plasticity. Prog Neurobiol. 233: 102568, 2024.
12. Noda T, Shinohara H, Kobayashi S, Taira A, Oura S, Duritahala, Tokuyasu M, Araki K, Ikawa,M: Multiple genes in the Pate5-13 genomic region contribute to ADAM3 processing. Biol
Reprod. in press. 2024.
13. Okumura K, Morinaga T, Saito M, Tokunaga Y, Otoyama K, Tanaka S, Isogai E, Kawazu M,
Togashi Y, Araki K. Wakabayashi Y: Deletion of Pak1 in CD11c positive cells confers resistanceto mouse skin carcinogenesis. J Invest Dermatol. in press. 2024

〇疫学研究部門
23）公衆衛生学講座
1.

Fukushige M, Lu X, Satoh M, Oda M, Ohba T, Katoh T.
Association between antinuclear antibody positivity and chemical exposure among pregnant
Japanese women: a cross-sectional study based on the Japan Environment and Children’s
Study.Int J Hyg Environ Health. 248:114094. doi:10.1016/j.ijheh.2022.114094, 2023.

2.

Futakawa K, Matsumura K, Tsuchida A, Konishi M, Sasaki H, Mezawa H, Yamamoto–Hanada
K, Inadera H, Hasegawa T, Kamijima M,Yamazaki S, Ohya T, Kishi R, Yaegashi N, Hashimoto
K, Mori C, Ito S, Yamagata Z, Nakayama T, Sobue T, Shima M, Nakamura H, Suganuma N,
Kusuhara K, Katoh T.
Longitudinal study of the relationship between number of prior miscarriages or stillbirths andchanges in quality of life of pregnant women: the Japan Environment and Children’s Study(JECS).BMC Pregnancy Childbirth. 23(1):297. doi: 10.1186/s12884-023-05578-6, 2023.

3.

Kato T, Fujii M, Kanatani K, Niwa F, Hirabayashi K, Nakayama T, Itakura S, Kamijima M,
Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera
H, Nakayama T, Iso H, Shima M, Nakamura H, Suganuma N, Kusuhara K, Katoh T.
Paternal involvement in infant care and developmental milestone outcomes at age 3 years: theJapan Environment and Children’s Study (JECS).
Pediatric Research. doi: 10.1038/s41390-023-02723-x. Online ahead of print, 2023.

4.

Kikuchi K, Michikawa T, Morokuma S, Hamada N, Suetsugu Y, Ikeda S, Nakahara K, Kato K,
Ochiai M, Shibata E,Tsuji M,Shimono M, Kawamoto T, Ohga S, Kusuhara K, Kamijima M,
Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera
H, Nakayama T, Iso H, Shima M, Kurozawa Y, Suganuma N, Katoh T.
Sleep quality and temperament in association with autism spectrum disorder among infants inJapan. Commun Med. 3(1):82. doi: 10.1038/s43856-023-00314-9, 2023.

5.

Lu X, Masuda S, Horlad H, Katoh T.
Safety and adverse effects of the coronavirus disease 2019 vaccine among the general Japanese
adult population.Vaccine. 7;41(35):5090-5096. doi: 10.1016/j.vaccine.2023.04.053, 2023.

6.

Lu X, Hojo S, Mizukoshi A, Katoh T.
Prevalence and correlation of multiple chemical sensitivity and electromagnetic
hypersensitivity with age, sex, and depression in the Japanese population: a retrospective study.
BMC Public Health. 21; 23(1):1205. doi: 10.1186/s12889-023-16152-2, 2023.

7.

Nakano K, Kuraoka S, Oda M, Ohba T, Mitsubuchi H, Nakamura K, Katoh T, The Japan
Environment and Children’s Study Jecs Group.Relationship between the Mediterranean Diet
Score in Pregnancy and the Incidence of Asthma at 4 Years of Age: The Japan Environment andChildren’s Study. Nutrients. 15(7):1772. doi: 10.3390/nu15071772, 2023.

8.

Nakamura M, Ohba T, Sasaki R, Saito F, Yamaguchi M, Motohara T, Mabe H, Lu X, Katabuchi
H, Kondoh E.Advantages and limitations of estrogen replacement therapy on hypogonadal
survivors of childhood cancer.Int J Clin Oncol. 30. doi:10.1007/s10147-023-02405-y, 2023.

9.

Tsuchiya M, Tsuchiya S, Momma H, Ikeda R, Suzuki J, Nagatomi R, Yaegashi N, Arima T,
Igarashi K, Kamijima M, Yamazaki S, Ohya Y, Kishi R, Hashimoto K, Mori C, Ito S, Yamagata
Z, Inadera H, Nakayama T, Sobue T, Shima M, Nakamura H, Suganuma N, Kusuhara K, Katoh
T.Impact of Habitual Yogurt Intake in Mother–Child Dyads on Incidence of Childhood Otitis
Media: The Japan Environment and Children’s Study (JECS) Probiotics Antimicrob. doi:
10.1007/s12602-023-10086-2, 2023.

10. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang
LM, Kumasaka N, Nomura I, Ohya Y, Kamijima M, Yamazaki S, Ohya Y, Kishi R, Yaegashi N,
Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera H, Nakayama T, Iso H, Shima M, Kurozawa
Y, Suganuma N, Katoh T.Prenatal antibiotic use, caesarean delivery and offspring’s
foodprotein‐induced enterocolitis syndrome: A National Birth Cohort (JECS). Clin Exp
Allergy. 53(4):479-483. doi: 10.1111/cea.14286, 2023.

24）神経精神医学講座
1.

Yuuki S, Hashimoto M, Koyama A, Matsushita M, Ishikawa T, Fukuhara R, Honda K, Miyagawa
Y, Ikeda M, Takebayashi M.Comparison of caregiver burden between dementia with Lewy
bodies and Alzheimer's disease.Psychogeriatrics : the official journal of the JapanesePsychogeriatric Society．2023 Jul;23(4):682-689.

2.

Hirabayashi N, Honda T, Hata J, Furuta Y, Shibata M, Ohara T, Tatewaki Y, Taki Y, Nakaji S,
Maeda T, Ono K, Mimura M, Nakashima K, Iga J, Takebayashi M, Ninomiya T.Association
Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People
Without Dementia: The JPSC-AD Study.Nuerology．2023 Sep 12;101(11):e1108-e1117.

3.

Ichiki T, Koyama A, Imai M, Nishi Y, Abe Y, Fukunaga R, Murakami R, Nagaoka M,
Takebayashi M, Fujise N.The trajectory of non-depressed suicidal ideation in communitydwelling older people in a rural area in Japan: A prospective longitudinal study with a 3-year
follow-up.Psychogeriatrics．2023 Sep;23(5):831-837.

4.

Abe H, Okada-Tsuchioka M, Kajitani N, Omori W, Itagaki K, Shibasaki C, Boku S, Matsuhisa
T, Takebayashi M.
Serum levels of high mobility group box-1 protein (HMGB1) and soluble receptors of advanced
glycation end-products (RAGE) in depressed patients treated with electroconvulsive therapy.
Neuropsychopharmacology Reports．2023 Sep;43(3):359-364.

5.

Bun S, Suzuki K, Niimura H, Shikimoto R, Kida H, Shibata M, Honda T, Ohara T, Hata J, Nakaji
S, Maeda T, Ono K, Nakashima K, Iga JI, Takebayashi M, Ninomiya T, Mimura M; JPSC-AD
Study Group.Gender and age influence the association between gait speed and mild cognitive
impairment in community-dwelling Japanese older adults: from the Japan Prospective Studies
Collaboration for Ageing and Dementia (JPSC-AD).Psychogeriatrics. 2023 Nov;23(6):918929.

6.

Uragami M, Matsushita K, Shibata Y, Takata S, Karasugi T, Sueyoshi T, Masuda T, Nakamura T,
Tokunaga T, Hisanaga S, Yugami M, Sugimoto K, Yonemitsu R, Ideo K, Fukuma Y, Takata K,
Arima T, Kawakami J, Maeda K, Yoshimura N, Matsunaga H, Kai Y, Tanimura S, Shimada M,
Tateyama M, Miyamoto K, Kubo R, Tajiri R, Tian X, Homma F, Morinaga J, Yamanouchi Y,
Takebayashi M, Kajitani N, Uehara Y; Kumamoto Stop OsteoPorotic Hip Fractures (K-STOP)
Group; Miyamoto T．A machine learning-based scoring system and ten factors associated withhip fracture occurrence in the elderly．Bone.2023 Nov:176:116865.

7.

Tachibana A, Iga J, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y, Shimizu H,
Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M,
Nakashima K, Takebayashi M, Ninomiya T, Ueno S.Late-Life High Blood Pressure and Enlarged

Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons.
Journal of Geriatric Psychiatry and Neurology．2024 Jan;37(1):61-72.
8.

Miyako K, Kajitani N, Koga Y, Takizawa H, Boku S, Takebayashi M.
Identification of the antidepressant effect of electroconvulsive stimulation-related genes inhippocampal astrocyte.
J Psychiatr Res. 2024 Jan 4;170:318-327. doi: 10.1016/j.jpsychires.2024.01.004. Online

ahead of print.PMID: 38194849
9.

Koga Y, Kajitani N, Miyako K, Takizawa H, Boku S, Takebayashi M.
TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in
depression model mice.
J Psychiatr Res. 2024 Jan 6;170:375-386. doi: 10.1016/j.jpsychires.2024.01.007. Online aheadof print.

10. Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S,
Uezono Y, Aoki J, Takebayashi M.
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identificationof novel therapeutic target for depression.
Neuropsychopharmacology. 2024 Feb;49(3):561-572. doi: 10.1038/s41386-023-01727-9
11. Miyako K, Kajitani N, Koga Y, Takizawa H, Boku S, Takebayashi M.
Identification of the antidepressant effect of electroconvulsive stimulation-related
genes in hippocampal astrocyte.
J Psychiatr Res. 2024 Jan 4;170:318-327. doi: 10.1016/j.jpsychires.2024.01.004. Online

ahead of print.PMID: 38194849
12. Koga Y, Kajitani N, Miyako K, Takizawa H, Boku S, Takebayashi M.
TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes
in depression model mice.
J Psychiatr Res. 2024 Jan 6;170:375-386. doi: 10.1016/j.jpsychires.2024.01.007. Online

ahead of print.
13. Tachibana A, Iga J, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y,
Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T,
Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno S.

Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal
Regions of Community-Dwelling Japanese Older Persons.

Journal of Geriatric Psychiatry and Neurology．2024 Jan;37(1):61-72.
14. Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K,
Ohtsuki S, Uezono Y, Aoki J, Takebayashi M.
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in theidentification of novel therapeutic target for depression.

Neuropsychopharmacology. 2024 Feb;49(3):561-572. doi: 10.1038/s41386-023-017279
15. Ohara T, Tatebe H, Hata J, Honda T, Shibata M, Matsuura S, Mikami T, Maeda T,
Ono K, Mimura M, Nakashima K, Iga J, Takebayashi M, Tokuda T, Ninomiya T.
Plasma biomarkers for predicting the development of dementia in a communitydwelling older Japanese population.

Psychiatry and Clinical Neurosciences（in press）
16. Takasaki A, Hashimoto M, Fukuhara R, Sakuta S, Koyama A, Ishikawa T, Boku S, Ikeda
M, Takebayashi M.
Gesture imitation performance in community-dwelling older people: assessment of agesture imitation task in the screening and diagnosis of mild cognitive impairment anddementia.

Psychogeriatrics 24(2) 404-414 2024
17. Tachibana A, Iga J, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y,
Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima
K, Takebayashi M, Ninomiya T, Ueno S.
Serum high-sensitivity C-reactive protein and dementia in a community-dwellingJapanese older population: the Japan Prospective Studies Collaboration for Aging and
Dementia (JPSC-AD)

Scientific Reports (in press)

18. Takeshi Sakayori MD, PhD 1*; Ken Wada MD, PhD 2*; Minoru Takebayashi MD, PhD
3*; Satoshi Ueda MD, PhD 4*; Akihiko Machino MD, PhD 5*; Atsushi Yoshimura MD,

PhD 6*; Enami Sawayama MD, PhD 7*; Fumi Maruyama MD 8*; Haruka Tanabe MD,

PhD 9; Hidehiko Takahashi MD, PhD 10*; Hideki Azuma MD, PhD 11*; Hiraki
Koishikawa MD 12*; Hiroki Ozawa MD, PhD 13*; Kazuya Okuhira MD 14*; Kazuyuki
Yasuda MD, PhD 15*; Koichi Miyakawa MD, PhD 16*; Reiji Yoshimura MD, PhD 17*;
Shigeru Ozaki MD, PhD 18*; Shin Yokoyama MD, PhD 19*; Shinkichi Eto MD 20*; Shoko
Tomonaga MD 21*; Shuichi Isomura MD, PhD 22*; Tsukasa Nonomura MD 23*; Yoshiro
Okubo MD, PhD 1*Multicenter Observational Study of Electroconvulsive Therapy inJapan"J ECT (in press)〇データサイエンス・オミクス解析研究・支援部門
25）免疫ゲノム構造学研究室
1.

Kubara K, Yamazaki K, Miyazaki T, Kondo K, Kurotaki D, Tamura T, Suzuki Y: Lymph nodemacrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA
vaccines. Mol Ther, 2024 in press2.

Matsubara E, Yano H, Pan C, Komohara Y, Fujiwara Y, Zhao S, Shinchi Y, Kurotaki D, Suzuki
M: The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor TumorAssociated Macrophages. Cancers 15: 2250, 2023

3.

Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii
M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G: Exposure to
microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling
HSCs. J Exp Med 220: e20220962, 2023

4.

Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata
A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T,
Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara
M, Yamashita M, Shichino S, Tanaka M, Asano K: The early neutrophil-committed progenitors
aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell
Rep 42: 112165, 2023

5.

Komohara Y, Kurotaki D, Tsukamoto H, Miyasato Y, Yano H, Pan C, Yamamoto Y, Fujiwara Y:
Involvement of protumor macrophages in breast cancer progression and characterization ofmacrophage phenotypes. Cancer Sci 114: 2220-2229, 2023

6.

Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y,
Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E: Inositol pyrophosphate profilingreveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous
system. J Biol Chem 299: 102928, 2023

7.

Yamazaki K, Kubara K, Suzuki Y, Hihara T, Kurotaki D, Tamura T, Ito M, Tsukahara K:
Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophagesin vivo. Eur J Pharm Biopharm 183: 61-73, 2023