医療開発研究部門

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主な論文・著作・業績①Koizumi Y, Ahmad S, Ikeda M, Yashima-Abo A, Espina G, Sugimoto R, Sugai T, Iwaya T, Tamura G, Koeda K,Liotta LA, Takahashi F, Nishizuka SS; Helicobacter pylori Modulated Host Immunity in Gastric Cancer Patients
With S-1 Adjuvant Chemotherapy.Northern Japan Gastric Cancer Study Consortium.
J Natl Cancer Inst. 2022 Aug 8;114(8):1149-1158②Yaegashi M, Iwaya T, Sasaki N, Fujita M, Ju Z, Siwak D, Hachiya T, Sato K, Endo F, Kimura T, Otsuka K, Sugimoto
R, Sugai T, Liotta L, Lu Y, Mills GB, Nakagawa H, Nishizuka SS: Frequent post-operative monitoring of colorectal

システム医学西塚哲

医療開発研究部門

特任教授

博士（医学）

腫瘍学
定量生物学

cancer using individualised ctDNA validated by multiregional molecular profiling/ Br J Cancer. 2021
Apr;124(9):1556-1565.
③Iwaya T, Endo F, Takahashi F, Tokino T, Sasaki Y, Nishizuka SS: Frequent Tumor Burden Monitoring of
Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital
Polymerase Chain Reaction/ Gastroenterology. 2021 Jan;160(1):463-465.e4.
④Sasaki N, Iwaya T, Chiba T, Fujita M, Ju Z, Endo F, Yaegashi M, Hachiya T, Sugimoto R, Sugai T, Siwak DR, Liotta
LA, Lu Y, Mills GB, Nakagawa H, Nishizuka SS: Analysis of mutational and proteomic heterogeneity of gastriccancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA/ PLoS
One. 2020 Oct 7;15(10):e0239966.
⑤特許第6544783号「名称：がんの診断のためのプローブ/プライマーライブラリー」①Akiko Yashima-Abo , Koki Otsuka, Satoshi S Nishizuka: Editorial Comment to "A nomogram Based on a Collagen
Feature Support Vector Machine for Predicting the Treatment Response to Neoadjuvant Chemoradiotherapy in
Rectal Cancer Patients"/Editorial, Ann Surg Oncol. doi: 10.1245/s10434-021-10328-z. Online ahead of print(2021)②Yoshiaki Kuroda, Akiko Yashima-Abo, Daisuke Koyama, Jiro Kikuchi, Shigehisa Mori, Shigeki Ito, Yusuke
Furukawa: Bone marrow stromal cell-mediated degradation of CD20 leads to primary rituximab resistance in阿保亜紀子

医療開発研究部門

講師

博士（医学）

人体病理学

mantle cell lymphoma/Leukemia. 35:1506-1510(2021)（血液病理）➂阿保 亜紀子, 佐藤 孝, 菅井 有: 悪性リンパ腫診断での捺印細胞診の有用性について/岩手医学雑誌 72: 243-252(2021)

実験病理学④Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Usubuchi H, Sato S, Ota Y, YashimaAbo A, Nakamura T, Nakaya N, Harigae H, Sasano H, Ichinohasama R.: Immunohistochemical pattern of c-MYC
protein judged as "+/(weak)+/-" by a new notation correlates with MYC gene nontranslocation in large B-cell
lymphoma/Hum Pathol. 85:112-118(2019)⑤Yashima-Abo A, Satoh T, Shimosegawa K, Ishida Y, Masuda T.: Classical Hodgkin lymphoma occurring inassociation with progressive transformation of germinal center/ J Clin Exp Hematop. 54: 205-209(2014)

医療開発研究部門

氏名所属

職名取得学位

専門分野

主な論文・著作・業績①Kogo R, Manako T, Iwaya T, Nishizuka S, Hiraki H, Sasaki Y, Idogawa M, Tokino T, Koide A, Komune N,
Yasumatsu R, Nakagawa T. Individualized circulating tumor DNA monitoring in head and neck squamous cell
carcinoma. Cancer Medicine. 10.1002/cam4.4726. (2022)②Fujisawa R, Iwaya T, Endo F, Idogawa M, Sasaki N, Hiraki H, Tange S, Hirano T, Koizumi Y, Abe M, Takahashi T,Yaegashi M, Akiyama Y, Masuda M, Sasaki A, Takahashi F, Sasaki Y, Tokino T, Nishizuka SS. Early dynamics ofcirculating tumor DNA predict chemotherapy responses for patients with esophageal cancer. Carcinogenesis

開勇人

医療開発研究部門

助教

博士（農学）

分子細胞生物学

42(10) 1239-1249 (2022)

生理学③Hiraki H, Uemura M, Kawamura Y. : Calcium signaling-linked CBF/DREB1 gene expression was induced
depending on the temperature fluctuation in the field: views from the natural condition of cold acclimation / Plantand Cell Physiology 60: 303-317 (2019)④文部科学省学術研究助成基金助成金（研究活動スタート支援）課題名：癌細胞Ca2+シグナルに関連した薬剤抵抗性と治療標的分子の同定．2019年（代表者）⑤文部科学省学術研究助成基金助成金（若手研究）課題名：がん細胞の分子標的薬に対する抵抗性とカルシウムシグナ
ルの関連．2020年（代表者）