඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕ࡢ 1 ஙඣ౛⑕౛ሗ࿌
࣏࢝ࢪỈ①ᵝⓎ⑈⑕㢮ఝࡢⓎ⑈ࢆ࿊ࡋࡓ
඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕ࡢ 1 ஙඣ౛                                               ༓ⴥ࿴἞ 1)ࠊஂ㛫ᮌᝅ 2)ࠊሀ⏣᭷Ᏹ 2)ࠊ᪥ୗዉ㒔Ꮚ 2)ࠊᯇཎᐜᏊ 2)ࠊ㕥ᮌ⳯⤮Ꮚ 2)ࠊ▼⏣ᬛஅ 2)㔝ཱྀ㔛ᜨ 2)ࠊ኱἟Ⰻ୍ 2)ࠊຍ㈡ඖ᐀ 2)ࠊ⏣⃝㞝స 2)ࠊ୰Ụಙ⩏ 2)ࠊ㈗⏣ᒸ⠇Ꮚ 2) ࠊ㣤⃝⌮ 3)ࠊ᪂஭ᐉ༤ 4)Ọ஭ᖾኵ 5)1) ௝ྎ་⒪ࢭࣥࢱ࣮ ◊ಟ་ ᑠඣ⛉2) ௝ྎ་⒪ࢭࣥࢱ࣮ ᑠඣ⛉3) ௝ྎ་⒪ࢭࣥࢱ࣮ ⓶⭵⛉4) ᮌ⏫ᑠඣ⛉ࠊ5) Ọ஭ᑠඣ⛉Ӑᢒ㘓ӑ
⑕౛ࡣ 5 ࠿᭶⏨ඣࠋ⏕ᚋ 2 ࠿᭶㡭࠿ࡽ࢔ࢺࣆ࣮ᛶ⓶⭵⅖ࢆ␲ࢃࢀࢫࢸࣟ࢖ࢻእ⏝๣࡟ࡼࡿ἞⒪ࡀ⾜࡞ࢃࢀ࡚࠸ࡓࠋᙜ⛉ཷデ๓᪥࠿ࡽయᖿ㒊࡟ᑠୣ⑈ࡀฟ⌧ࡋࠊⓎ⇕ࡶຍࢃࡗ࡚ࡁࡓࡓࡵ㏆་ཷデࡋࡓ࡜ࡇࢁࠊ࣏࢝
ࢪỈ①ᵝⓎ⑈⑕ࢆ␲ࢃࢀᙜ⛉⤂௓ࠊධ㝔࡜࡞ࡗࡓࠋධ㝔᫬ࠊయᖿ㒊ࢆ୰ᚰ࡟Ỉ⑁ࢆక࠺ᑠୣ⑈ࡀከᩘㄆࡵࡽࢀࡓࠋỈ⑁ෆᐜ≀ࡢ᳨ᰝ࡛ࡣࣄࢺ༢⣧࣊ࣝ࣌ࢫ࢘࢖ࣝࢫᢠཎࡣ㝜ᛶ࡛ࠊ⾑Ύᢠయ౯ࡶ᳨ฟឤᗘ௨ୗ࡛࠶ࡗࡓࠋ➨ 5 ⑓᪥࡟ẕぶࡀⓎ⇕ࡋᅄ⫥࡟Ỉ⑁ࢆక࠺ᑠୣ⑈ࡶฟ⌧ࡋࡓࡓࡵᡭ㊊ཱྀ⑓࡜デ᩿ࡋࡓࠋࡇࡢ᫬Ⅼ࡛ᝈඣࢆ෌ᗘὀព῝ࡃデᐹࡋࡓ࡜ࡇࢁཱྀ⭍ෆ࡟ᑡᩘࡢ⢓⭷⑈ࢆㄆࡵࠊᡭᤸ࣭㊊ᗏ࡟ࡶୣ⑈ࡀᩘಶᩓᅾࡋ࡚࠸ࡓࠋᝈඣ
ࡢᢠࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫ A6 ᆺ㸦CVA6㸧ᢠయ౯ࡣ࣌࢔⾑Ύ࡛᭷ព࡟ୖ᪼ࡋ࡚࠸ࡓࡇ࡜࠿ࡽࠊCVA6 ࡟ࡼࡿ඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕࡜デ᩿ࡋࡓࠋ࢔ࢺࣆ࣮ᛶ⓶⭵⅖ࡀ࠶ࡿሙྜࠊᮏ⑕౛ࡢࡼ࠺࡟ CVA6ឤᰁ⑕࡛ࡶ࣏࢝ࢪỈ①ᵝⓎ⑈⑕㢮ఝࡢⓎ⑈ࢆ࿊ࡍࡿࡇ࡜ࡀ࠶ࡿࡓࡵࠊయᖿ㒊ࢆ୰ᚰ࡟Ỉ⑁ࢆక࠺ᑠୣ⑈ࡀከⓎࡍࡿ⑕౛࡛ࡣ㠀඾ᆺⓗ࡞ᡭ㊊ཱྀ⑓ࡢྍ⬟ᛶࡶᛕ㢌࡟⨨ࡁ࡞ࡀࡽ㚷ูデ᩿ࢆࡍࡍࡵࡿᚲせࡀ࠶ࡿࠋ                                               ࣮࣮࢟࣡ࢻ㸸ᡭ㊊ཱྀ⑓ࠊ඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕ࠊࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫ A6 ᆺࠊ࣏࢝ࢪỈ①ᵝⓎ⑈⑕ࠊ࢔ࢺࣆ࣮ᛶ⓶⭵⅖㸦2013 ᖺ 11 ᭶ 23 ᪥ཷ㡿ࠊ2014 ᖺ 1 ᭶ 18 ᪥᥇⏝㸧㸯 ึࡵ࡟⭸㛵⠇ࠊ⮌㒊࡟ࡶฟ⌧ࡍࡿࡀࠊయᖿ㒊ࢆ୰ᚰ࡟Ⓨ⑈࣏࢝ࢪỈ①ᵝⓎ⑈⑕ࡣࠊ࢔ࢺࣆ࣮ᛶ⓶⭵⅖࡞࡝ࡢࡀฟ⌧ࡍࡿࡇ࡜ࡣᑡ࡞࠸ 2)ࠋࡋ࠿ࡋࠊ㏆ᖺᑠඣ࡟࠾

⑓ኚ㒊఩ࠊ≉࡟㢦㠃ࠊయᖿ࡟ᑠỈ⑁ࡀከⓎࡍࡿ⑌ᝈ࠸࡚ᡭ㊊ཱྀ⑓ࡢ඲㌟ᆺࡢሗ࿌ࡀቑ࠼࡚ࡁ࡚࠾ࡾࠊࡑ

࡛ࠊࣄࢺ༢⣧࣊ࣝ࣌ࢫ࢘࢖ࣝࢫ㸦HSV㸧ࡢ⮬ᐙ᥋✀ࡢཎᅉ࢘࢖ࣝࢫࡢ୍ࡘ࡜ࡋ࡚ࢥࢡࢧࢵ࣮࢟࢘࢖ࣝ࡟ࡼࡾⓎ⑕ࡍࡿ 1)ࠋ୍᪉ࠊᡭ㊊ཱྀ⑓ࡣᩥᏐ㏻ࡾࠊᡭ

ࢫ A6 ᆺ㸦CVA6㸧ࡀ♧ࡉࢀ࡚࠸ࡿ 3)ࠋ௒ᅇᡃࠎࡣయ

㊊ཱྀ࡟Ỉ⑁ᛶⓎ⑈ࡀぢࡽࢀࡿ⑌ᝈ࡛ࠊ࡜ࡁ࡟ୗ⭣ࠊᖿ㒊ࢆ୰ᚰ࡟࣏࢝ࢪỈ①ᵝⓎ⑈⑕㢮ఝࡢⓎ⑈ࢆ࿊44

௝ྎ་⒪ࢭࣥࢱ࣮་Ꮫ㞧ㄅ Vol 4, 2014
ࡋࡓ CVA6 ࡟ࡼࡿ඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤ

࡟ୖ᪼ࡋ࡚࠸ࡓࠋ⥲ IgE ࡣ 79.7IU/ml ࡛ࠊ≉␗ⓗᰁ⑕ࡢஙඣ౛ࢆ⤒㦂ࡋࡓࡢ࡛ሗ࿌ࡍࡿࠋ

IgE ᢠయ౯ࡣ༸ⓑ 6.14UA/ml㸦ࢡࣛࢫ㸱㸧ࠊ༸㯤ࠊ∵ங 0.74UA/ml㸦ࢡࣛࢫ㸰㸧ࠊ
1.53UA/ml㸦ࢡࣛࢫ㸰㸧㸰 ⑕౛࢝ࢮ࢖ࣥ 0.42UA/ml㸦ࢡࣛࢫ㸯㸧࡛࠶ࡗࡓࠋࡲࡓࠊ

⑕౛㸸5 ࠿᭶ࠊ⏨ඣࠋỈ⑁㒊᧿㐣࡟ࡼࡿࣄࢺ༢⣧࣊ࣝ࣌ࢫ࢘࢖ࣝࢫ୺ッ㸸యᖿ㒊ࡢⓎ⑈ࠊⓎ⇕ࠋ㸦HSV㸧ᢠཎ᳨ᰝࡣ㝜ᛶ࡛ࠊHSV ᢠయ౯࠾ࡼࡧỈᐙ᪘Ṕ㸸∗ẕࡀⰼ⢊⑕ࠋ①ᖏ≧⑁⑈࢘࢖ࣝࢫ㸦VZV㸧ᢠయ౯ࡶ㝜ᛶ࡛࠶ࡗࡓࠋ᪤ Ṕ㸸⏕ᚋ 2 ࠿᭶࠿ࡽஙඣ‵⑈ࡀ࠶ࡾࠊ࢔ࢺࣆ࣮ᛶ⓶⭵⅖ࢆ␲ࢃࢀ㏆་࡛ࢫࢸࣟ࢖ࢻእ⏝⸆ሬᕸ୰ࠋ⌧⑓Ṕධ㝔๓᪥ࡢኪ㛫ࡼࡾయᖿ㒊࡟⓶⑈ࡀฟ⌧ࡋࡓࠋ⩣᪥࡟ 38ΥྎࡢⓎ⇕ࡶຍࢃࡗࡓࡓࡵ㏆་ࢆཷデࡋࠊ࣏࢝ࢪỈ①ᵝⓎ⑈⑕ࢆ␲ࢃࢀ࡚ᙜ⛉⤂௓ࠊධ㝔࡜࡞ࡗࡓࠋධ㝔᫬⌧⑕య㔜 7250gࠊ⬦ᢿ 124 ᅇ/ศࠊయ39.6Υࠋయᖿ㒊ࢆ୰ᚰ࡟⣚ᩬࢆక࠺୍㒊⑐⓶໬ࡋࡓୣ⑈ࢆㄆࡵࡓࠋ
㸦ᅗ 1㸧ࠋ㤳ࡸᡭ㛵⠇࿘ᅖ࡞࡝ࠊᒅ᭤㒊௜㏆࡟ࡣ࢔ࢺࣆ࣮ᛶ⓶⭵⅖ࡢᡤぢࡶΰᅾࡋ࡚࠸ࡓࠋᥙ⑛ឤࡀ
ᙉࡃయືࢆㄆࡵࡓࠋᡭᤸ࣭㊊ᗏࡸཱྀ⭍ෆ࡟᫂ࡽ࠿࡞Ⓨ⑈ࢆㄆࡵࡎࠋ࿧྾㡢࡛ࡣ㍍ᗘ྾Ẽᛶႍ㬆࠶ࡾࠋ⭡⾲㸯 ධ㝔᫬᳨ᰝᡤぢ㒊ࡣᖹᆠ࣭㌾࡛⫢࠾ࡼࡧ⭁ࡣゐ▱ࡋ࡞࠿ࡗࡓࠋධ㝔ᚋ⤒㐣ධ㝔᫬᳨ᰝᡤぢ㸦⾲㸯㸧ධ㝔᫬ࠊⓎ⑈ࡢᛶ≧࠿ࡽ࣏࢝ࢪỈ①ᵝⓎ⑈⑕ࢆ␲ⓑ⾑⌫ᩘࡣ 9200/Pl ࡜ṇᖖ⠊ᅖ࡛࠶ࡗࡓࡀࠊ⏕໬࠸࢔ࢩࢡࣟࣅࣝࡢ⤒㟼⬦ᢞ୚ࢆ㛤ጞࡋࡓࠋධ㝔⩣᪥Ꮫ᳨ᰝ࡛ࡣ CRP ࡀ 0.5mg/dl ࡜ࢃࡎ࠿࡟ୖ᪼ࡋࠊ࡟⓶⭵⛉ࢆཷデࡋ⓶⑈㒊࡬ࡢ࢔ࢬࣀ࣮ࣝሬᕸ࡜ࠊ஧ḟឤᰁண㜵┠ⓗ࡛ࢭࣇ࢛ࢳ࢔࣒ࡢ⤒㟼⬦ᢞ୚ࡀ㛤ጞ࡜࡞ࡗࡓࠋධ㝔 3 ᪥┠࡟ࡣゎ⇕ࡋࠊయᖿ㒊Ⓨ⑈ࡣῐ〓Ⰽࡢ⑐⓶ࢆṧࡋ࡚ᾘ〣ࡋࡓࡀࠊᒅ᭤㒊ࡢ⓶⑈ࡣṧᏑࡋ࡚࠸ࡓࠋධ㝔 4 ᪥┠㸦➨ 5 ⑓᪥㸧࡟ẕぶࡀⓎ⇕ࡋࠊྠ᫬࡟ẕぶࡢᅄ⫥࡟Ỉ⑁ࢆక࠺ᑠୣ⑈ࡀฟ⌧ࡋࡓࠋࡇࡢࡓࡵ෌ᗘᝈඣࡢཱྀ⭍ෆᡤぢࢆ☜ㄆࡍࡿ࡜ᑠᩘࡢ⢓⭷⑈ࢆㄆࡵࠊᡭᤸ࣭㊊ᗏ࡟ࡶᑠୣ⑈ࡀᩘಶ
ᩓᅾࡋ࡚࠸ࡓ㸦ᅗ 2㸧ࠋ⮫ᗋᡤぢ࠾ࡼࡧ⤒㐣࠿ࡽᡭ㊊ཱྀ⑓ࢆ␲࠸᳨ᰝࢆ⾜ࡗࡓࠋᅗ㸯 ึデ᫬ࡢ⓶⑈ࠋయᖿ㒊ࡢ࢔ࢺࣆ࣮ᛶ⓶⭵⅖㒊ࢆ୰ᚰ࡟ᑠୣ⑈ࡀከᩘㄆࡵࡽࢀࠊ୍㒊ࡣῐ〓Ⰽࡢ⑐⓶ࢆకࡗ࡚࠸ࡓࠋ

AST 75mU/ml, ALT 57mU/ml ࡜㍍ᗘࡢ⫢㓝⣲ࡢ␗ᖖࢆㄆࡵࡓࠋࡲࡓࠊCK ࡶ 240mU/ml ࡜ࢃࡎ࠿45

඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕ࡢ 1 ஙඣ౛ᅗ㸰 ➨  ⑓᪥ࡢ⓶⑈ࠋᑠୣ⑈ࡀᡭᤸ࠾ࡼࡧ㊊ᗏ࡟ᩘಶㄆࡵ
ࡽࢀࡓࠋ

⾲ 2 ࡟♧ࡍࡼ࠺࡟ᢠ CVA6 ᢠయ౯ࡣ➨ 5 ⑓᪥࡟ࡣ128 ಸ࡛࠶ࡗࡓࡀࠊ➨ 16 ⑓᪥⑓᪥࡟ࡣ 4,096 ಸ࡜⾲㸱 㠀඾ᆺⓗ࡞Ⓨ⑈ࢆ࿊ࡋࡓᡭ㊊ཱྀ⑓⑕౛  ౛ࡢࡲ࡜ࡵ

࣌࢔⾑Ύ࡛ 32 ಸࡢୖ᪼ࡀࡳࡽࢀࠊCVA6 ࡟ࡼࡿᡭ࡚Ⓨ⑈ࡢᙧែࡀᵝࠎ࡛ࠊฟ⌧㒊఩ࡸᗈࡀࡾࡶ␗࡞ࡗ㊊ཱྀ⑓࡜デ᩿ࡋࡓࠋ࡚࠸ࡓࠋయ⾲㠃✚ࡢ 10%௨ୖࡢⓎ⑈ࡀ 61%ࡢᝈ⪅࡟ㄆࡵࡽࢀࠊⓎ⑈ࡢฟ⌧㒊఩ࡶᚑ᮶ࡢᡭ㊊ཱྀ⑓࡛ࡳࡽࢀࡿᡭᤸࠊ㊊ᗏࠊ⮌㒊ࡢ࡯࠿࡟ࠊཱྀ࿘ᅖࠊᅄ⫥ࡸయᖿ㒊࡟ࡶㄆࡵࡽࢀࡓࠋࡉࡽ࡟ 55%ࡢᝈ⪅࡛ࡣ⓶⭵
⅖ࢆ࠾ࡇࡋ࡚࠸ࡿ㒊఩࡟୍⮴ࡋ࡚࣊ࣝ࣌ࢫᛶ‵⑈ᵝࡢⓎ⑈ࡀฟ⌧ࡋࡓࠋࡋ࠿ࡋࠊ࡞ࡐ CVA6 ࡀ⓶⭵⅖⾲㸰 ࢥࢡࢧࢵ࢟㸫࢘࢖ࣝࢫᢠయ౯ࡢ࠶ࡿ㒊఩࡟Ỉ⑁ᛶⓎ⑈ࡸࡧࡽࢇࢆዲⓎࡋ࡚ࡃࡿࡢ࠿࡟ࡘ࠸࡚ࡣࠊࡲࡔⰋࡃࢃ࠿ࡗ࡚࠸࡞࠸ 3, 7)ࠋࡲ㸱 ⪃ᐹ
ᡭ㊊ཱྀ⑓ࡣဗ㢌⑓ኚ࡜ᡭᤸ࣭㊊ᗏࡢỈ⑁ᛶⓎ⑈࡛ࡓࠊỈ⑁ᛶ⑓ኚࡀᾘ〣ࡍࡿࡇࢁ࡟ᡭᤸࡸ㊊ᗏࡢ⾲⓶≉ᚩ࡙ࡅࡽࢀࡿ⑌ᝈ࡛࠶ࡿ 2)ࠋ඾ᆺⓗ࡞⑕≧࠾ࡼࡧ๤㞳ࡀ㉳ࡇࡗࡓࡾࠊ3㹼8 㐌ᚋ࡟∎ࡀ∎ᗋ࠿ࡽ๤ࢀ⮫ᗋᡤぢࡣⓎ⇕ࠊཱྀ⭍ෆࡧࡽࢇࠊࡑࡋ࡚ᡭࠊ㊊ࠊ⮌ࡓࡾࡍࡿࡇ࡜㸦Onychomadesis㸧ࡶ࠶ࡿ 3)ࠋ

㒊ࡢ෇ᙧᑠỈ⑁࡛࠶ࡿࠋ5 ṓᮍ‶ࡢࡇ࡝ࡶ࡟ዲⓎࡋࠊᮏ⑕౛࡛ࡶⓎ⑈ࡣయᖿ㒊ࢆ୰ᚰ࡟ᗈࡃㄆࡵࡽࢀࠊ⣅ཱྀឤᰁࠊỈ⑁ᾮࠊ㣕ἓឤᰁ࡛ឤᰁࡍࡿࠋࢥࢡࢧࢵࡑࡢᙧែ࠿ࡽࡣ HSV ࡟ࡼࡿ࣏࢝ࢪỈ①ᵝⓎ⑈⑕࡜࣮࢟࢘࢖ࣝࢫ A16 ᆺ࡜࢚ࣥࢸࣟ࢘࢖ࣝࢫ 71 ࡢ 2 ࡘࡢ㚷ูࡀᅔ㞴࡛࠶ࡗࡓࠋࡋ࠿ࡋࠊ⤒㐣୰࡟ẕぶࡀ඾ࡀᡭ㊊ཱྀ⑓ࡢ௦⾲ⓗ࡞㉳ᅉ࢘࢖ࣝࢫ࡛࠶ࡿ 4-6)ࠋ

ᆺⓗ࡞ᡭ㊊ཱྀ⑓ࢆⓎ⑕ࡋࡓࡓࡵࠊ࣌࢔⾑Ύ࡛ࢥࢡࢧ

㏆ᖺࠊᡭ㊊ཱྀ⑓࡟࠾࠸࡚ࠊ㠀඾ᆺⓗ࡞⓶⑈ࡢฟ⌧ࢵ࣮࢟࢘࢖ࣝࢫᢠయ౯ࡢ ᐃࢆ⾜࡞ࡗࡓ࡜ࡇࢁࠊᢠ

ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋ≉࡟ 2011 ᖺ࠿ࡽ 2012 ᖺ࡟࠿CVA6 ᢠయ౯ࡢୖ᪼ࡀࡳࡽࢀ඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘

ࡅ࡚໭⡿኱㝣࡛ὶ⾜ࡋࡓᡭ㊊ཱྀ⑓࡛ࡣ㠀඾ᆺⓗ࡞࢖ࣝࢫឤᰁ⑕࡜デ᩿ࡋࡓࠋ௨ୖࡢࡇ࡜࠿ࡽࠊᮏ⑕౛Ⓨ⑈ࢆ࿊ࡋࡓ⑕౛ࡀከࡃࠊMathes ࡽࡢሗ࿌࡟ࡼࡿࡢࡼ࠺࡟⓶⭵⅖࠶ࡿ࠸ࡣ‵⑈ࡢ࠶ࡿ㒊఩࡟᪂ࡓ࡟࡜㠀඾ᆺⓗ࡞ᡭ㊊ཱྀ⑓ࡢᑠඣ౛ 80 ౛ࢆゎᯒࡋࡓ࡜Ỉ⑁ࢆక࠺ᑠୣ⑈ࡀฟ⌧ࡋࡓሙྜ࡟ࡣ࢚ࣥࢸࣟ࢘

ࡇࢁࠊࡑࡢ࠺ࡕ 17 ౛࡛ CVA6 ࡀ᳨ฟࡉࢀࡓ 6)ࠋࡑ࢖ࣝࢫឤᰁ⑕ࠊ≉࡟ CVA6 ࡟ࡼࡿឤᰁ⑕ࢆ㚷ู⑌ᝈࡢ≉ᚩࡣ⾲ 3 ࡟♧ࡍࡼ࠺࡟ࠊᚑ᮶ࡢᡭ㊊ཱྀ⑓࡟ẚ࡭࡜ࡋ࡚ᛕ㢌࡟ධࢀ࡚࠾ࡃᚲせࡀ࠶ࡿࠋᅜ❧ឤᰁ⑕◊✲ᡤ࠿ࡽࡢሗ࿌࡟ࡼࡿ࡜᪥ᮏ࡛ࡣ
2011 ᖺ࡜ 2013 ᖺ࡟ CVA6 ࡟ࡼࡿᡭ㊊ཱྀ⑓ࡀὶ⾜ࡋࡓ 8)ࠋྠ᫬ᮇ࡟㠀඾ᆺⓗ࡞ᡭ㊊ཱྀ⑓⑕౛ࡀ」ᩘ౛
ᙜ⛉ࢆཷデࡋ࡚࠸ࡿࠋࡑࡢ୰࡛ᕧ኱࡞ᡭᤸ࣭㊊ᗏࡢ

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௝ྎ་⒪ࢭࣥࢱ࣮་Ꮫ㞧ㄅ Vol 4, 2014of 100 cases. J Am Acad Dermatol. 2003;
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Ỉ⑁ࡀࡳࡽࢀࡓ⑕౛ࢆ⤂௓ࡍࡿ㸦ᅗ 3㸧ࠋࡇࡢ⑕౛

2006;55:1-20

ࡣ 2 ṓ 10 ࠿᭶⏨ඣ࡛ࠊయᖿ㒊࡟࣏࢝ࢪỈ①ᵝⓎ⑈6) Ho M, Chen ER, Hsu KH, et. al.. An epidemic⑕㢮ఝࡢⓎ⑈ࢆㄆࡵࡓࡀࠊᡭᤸ࣭㊊ᗏࡢỈ⑁ࡀ┠❧of enterovirus 71 infection in Taiwan. Taiwanࡗࡓࡇ࡜࠿ࡽᡭ㊊ཱྀ⑓ࢆ␲࠸ࠊࢥࢡࢧࢵ࣮࢟࢘࢖ࣝ

Enterovirus Epidemic Working Group. Nࢫᢠయ౯ࡢ ᐃࢆ⾜࡞ࡗࡓࠋࡑࡢ⤖ᯝࠊᢠ CVA10Engl J Med. 1999; 341:929-935

ᢠయ౯ࡀ 128 ಸ࡜㝧ᛶ࡛࠶ࡗࡓࡀࠊᢠ CVA6 ᢠయ7) Wollenberg A, Wetzel S, Burgdorf WH, et. al.

౯ࡣ 8 ಸᮍ‶࡜㝜ᛶ࡛࠶ࡗࡓࠋࡇࡢࡼ࠺࡟ࠊCVA6

Viral infections in atopic dermatitis:௨እ࡛ࡶ㠀඾ᆺⓗ࡞ᡭ㊊ཱྀ⑓ࢆ࿊ࡋ࡚ࡃࡿ౛ࡀ࠶

pathogenic aspects and clinical management.

ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ

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8) Infectious Diseases Weekly Report Japan2013 ᖺ➨ 31 㐌㸦7 ᭶ 29 ᪥㹼8 ᭶ 4 ᪥㸧㸬㸲 ⤖ㄒ࣏࢝ࢪỈ①ᵝⓎ⑈⑕㢮ఝࡢⓎ⑈ࢆ࿊ࡋࡓ CAV6

http://www0.nih.go.jp/niid/idsc/idwr/IDWR20
13/idwr2013-31.pdf㸸2013;15:1-36

࡟ࡼࡿ඲㌟ᆺࢥࢡࢧࢵ࣮࢟࢘࢖ࣝࢫឤᰁ⑕ࡢஙඣ౛ࢆሗ࿌ࡋࡓࠋయᖿ㒊ࢆ୰ᚰ࡟Ỉ⑁ࢆక࠺ᑠୣ⑈ࡀㄆࡵࡽࢀࡿ⑕౛࡛ࡣࠊ㠀඾ᆺⓗ࡞ᡭ㊊ཱྀ⑓ࡢྍ⬟ᛶࡶᛕ㢌࡟⨨ࡁ࡞ࡀࡽ㚷ูデ᩿ࢆࡍࡍࡵࡿᚲせࡀ࠶ࡿࠋᮏ⑕౛ࡢせ᪨ࡣᐑᇛ┴ᑠඣ⛉་఍Ꮫ⾡ㅮ₇఍㸦2013 ᖺ10᭶ ௝ྎ㸧࡟࡚Ⓨ⾲ࡋࡓࠋ㸳 ᩥ⊩1) Wollenberg A, Zoch C, Wetzel S, et, al..
Predisposing factors and clinical features ofeczema herpeticum: a retrospective analysis

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