東京都医学総合研究所年報
２０１９年 版

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東京都医学総合研究所

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◊✲άື㸦2018 ᖺᗘ㸧   㸯㸬་Ꮫ⥲ྜ◊✲ᡤ࡛ྲྀࡾ⤌ࡴ◊✲ㄢ㢟 1

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◊✲ࡢᚲせᛶձ ࢤࣀ࣒࡜ ࡀࢇࡀࢇ࡜䛜䜣⣽⬊䛾䝀䝜䝮䛿䛂୙Ᏻᐃ䛃䛷䛒䜚ከ䛟䛾ኚ␗䚸㑇ఏᏊ␗ᖖ䜢⵳✚䛧䛶䛔䜛䚹䝀䝜䝮୙Ᏻᐃᛶ䛿䚸ᰁⰍయ䛾」〇䜔ಟ᚟䚸ศ㓄䛺䛹䜢ᢸ䛖ᶵ⬟䛾␗ᖖ䛸῝䛟㛵㐃䛩䜛䚹ᮏ◊✲ㄢ㢟䛷䛿䚸ᰁⰍయ䞉䝀䝜䝮䛾ୡ௦䜢㏻䛨䛯Ᏻᐃ䛺⥔ᣢ䚸⥅ᢎ䛾䝯䜹䝙䝈䝮䚸䛭䛾୙඲䛜䜒䛯䜙䛩⣽⬊䝺䝧䝹䚸ಶయ䝺䝧䝹䛷䛾␗ᖖ䜢ゎ᫂䛩䜛䛸䛸䜒䛻䚸✀䚻䛾䛜䜣⣽⬊䚸⭘⒆䛾䝀䝜䝮䚸䜶䝢䝀䝜䝮䝺䝧䝹䛷䛾ኚ໬䚸㑇ఏⓗ≉ᛶ䚸䛒䜛䛔䛿␗ᖖቑṪ䛾ᇶ┙䛸䛺䜛⣽⬊࿘ᮇ䞉ᰁⰍయ䝃䜲䜽䝹ไᚚ␗ᖖ䜢ゎ᫂䛩䜛䚹䛣䜜䜙䛾▱ぢ䛿䚸䛜䜣ᚁᅽ䛾䛯䜑䛾᪂䛧䛔ศᏊᶆⓗ䛾Ⓨぢ䜢䜒䛯䜙䛩䛸䛸䜒䛻䚸䛜䜣䛾䝍䜲䝥䛻ᇶ䛵䛔䛯
ಶู἞⒪ἲ䛾㛤Ⓨ䛾ᇶ┙䛸䜒䛺䜛䚹䛜䜣䛾᧞⁛䛾䛯䜑䛻䛿䚸ண㜵䚸᪩ᮇⓎぢ䛜䛝䜟䜑䛶㔜せ䛷䛒䜛䚹䛭䜜䛸䛸䜒䛻䚸䛜䜣ᝈ⪅䛾ⱞ③䜢㍍ῶ䛩䜛἞⒪䜒ᮃ䜎䜜䜛䚹䛣䛾䛯䜑䛻ᮏ◊✲ㄢ㢟䛷䛿䚸✀䚻䛾䛜䜣⣽⬊䚸⭘⒆䛻䛚
䛡䜛䝞䜲䜸䝬䞊䜹䞊䛾ྠᐃ䛸⡆౽䚸㎿㏿䛺᪩ᮇデ᩿ἲ䛾㛤Ⓨ䜒䜑䛦䛧䚸䛜䜣䛾᪩ᮇⓎぢ䈄἞⒪ཬ䜃䛜䜣ᛶ⑊③䛾἞⒪䛾᪂䛯䛺ᡓ␎䜢ぢฟ䛩䚹ࡇࢀࡲ࡛ࡢ◊✲ᡂᯝ䖂䝀䝜䝮䛾Ᏻᐃ䛺⥔ᣢ䚸ఏᦙ
䛸Ⓨ䛜䜣䛾䝯䜹䝙䝈䝮䛾ゎ᫂䖂䛜䜣䝞䜲䜸䝬䞊䜹䞊䛾᥈⣴䛸㎿㏿䛺デ᩿ἲ䛾㛤Ⓨ䖂⑊③἞⒪䛻䛚䛡䜛㙠③⸆ឤཷᛶண 䝅䝇䝔䝮䛾㛤Ⓨឤᰁղ ឤᰁ⑕ࡢඞ᭹

⑕᪂⯆ཬ䜃㞴἞ᛶ䜴䜲䝹䝇ឤᰁ⑕䛾ண㜵䛻᭷ຠ䛺䝽䜽䝏䞁䜔᪂䛯䛺἞⒪ἲ䛾☜❧䜢䜑䛦䛩䚹᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛻ᑐ䛧䛶䝥䝺䝟䞁䝕䝭䝑䜽୙ά໬䝽䜽䝏䞁䛜ഛ␆䛥䜜䛶䛔䜛䚹䛧䛛䛧䚸ὶ⾜ᰴ䛜ண 䛷䛝䛺䛔䛣䛸䚸᥋✀ᚋຠᯝ䛜ฟ䜛䜎䛷㛗ᮇ㛫䛛䛛䜛䛣䛸䛜ၥ㢟ど䛥䜜䛶䛔䜛䚹䛭䛣䛷䚸༢ᅇ᥋✀䞉▷ᮇ㛫䛷䜒᭷ຠ䛺⤌᥮䛘⏕䝽䜽䝏䞁➼䛻䜘䜛ண㜵ἲ䛾☜❧䜢䜑䛦䛩䚹䜎䛯䚸㻯 ᆺ⫢⅖䜴䜲䝹䝇䚸㻮 ᆺ⫢⅖䜴䜲䝹䝇➼ᣢ⥆ឤᰁ໬䛩䜛䜴䜲䝹䝇⑌ᝈ䛾἞⒪䛿ᅔ㞴䛷䛒䜛䚹䜴䜲䝹䝇」〇䜢ᢚไ䛩䜛᰾㓟䜰䝘䝻䜾䜔䝥䝻䝔䜰䞊䝊㜼ᐖ๣➼䛜἞⒪䛻⏝䛔䜙䜜䛶䛔䜛䛜䚸⸆๣⪏ᛶ䜴䜲䝹䝇䛜ฟ⌧䛧᫆䛟䚸⤊⏕ᢞ⸆἞⒪䛜ᚲせ䛷䛒䜛䚹䛭䛣䛷䚸ᐟ୺ᅉᏊ䜢ᶆⓗ䛻䛧䛯ᢠ䜴䜲䝹䝇๣䛸ච␿䛻䜘䜛᤼㝖⣔䛾ᙉຊ䛺άᛶ໬䜢䜒䛯䜙䛩䛣䛸䛷䚸䛣䜜䜙᰿἞ᅔ㞴䛺䜴䜲䝹䝇⑌ᝈ䛾᏶඲䛺⑓ែไᚚ䜢䜑䛦䛩䚹䜎䛯䚸䝫䝸䜸䜴䜲䝹䝇䛾♧䛩ྥ⚄⤒ᛶ䛾ᶵᗎ䜢ゎᯒ䛩䜛䛣䛸䛻䜘䜚䡠⑓ཎ䜴䜲䝹䝇䛾⤌⧊≉␗ᛶ⋓ᚓᶵᗎ䜢᫂䜙䛛䛻䛩䜛䚹ճ ㄆ▱⑕࡜⚄⤒㞴⑓

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䜰䝹䝒䝝䜲䝬䞊⑓䜔䝟䞊䜻䞁䝋䞁⑓䚸䝺䝡䞊ᑠయᆺㄆ▱⑕䠄㻰㻸㻮䠅䚸๓㢌ഃ㢌ⴥኚᛶ⑕䠄㻲㼀㻸㻰䠅䚸➽ⴎ⦰ᛶഃ⣴◳໬⑕䠄㻭㻸㻿䠅䚸ከ⣔⤫ⴎ⦰⑕䚸⬨㧊ᑠ⬻ኚᛶ⑕➼䛷⵳✚䛩䜛␗ᖖ⺮ⓑ㉁䠄䝍䜴䚸䃐 䝅䝚䜽䝺䜲䞁䚸㼀㻰㻼㻙㻠㻟䚸䝫䝸䜾䝹䝍䝭䞁➼䠅䛾Ⓨ⌧ᶵᗎ䛸⚄⤒⣽⬊ኚᛶ㐣⛬䛾ゎ᫂䛻䜘䜚䚸䛣䜜䜙ㄆ▱⑕⑌ᝈ䜔ᡂேᮇ⚄⤒㞴⑓䛾デ᩿ἲ䞉἞⒪ἲ䛾㛤Ⓨ䜢⾜䛖䚹≉䛻䜰䝹䝒䝝䜲䝬䞊⑓⬻䜈䛾䜰䝭䝻䜲䝗 䃑 ⺮ⓑ㉁⵳✚䜢ῶᑡ䛥䛫䜛 㻰㻺㻭 䝽䜽䝏䞁䛾ᐇ⏝໬䜢᥎㐍䛩䜛䚹䛥䜙䛻䚸ከᵝ䛺⚄⤒㞴⑓䜔ᵝ䚻䛺ཎᅉ䛻㉳ᅉ䛩䜛ᮎᲈ⚄⤒㞀ᐖ䛻䛴䛔䛶䚸䝠䝖䛾⬻⚄⤒⣔䛾ゎᯒ䛸ື≀䞉⣽⬊䝰䝕䝹䛾ゎᯒ䛸䜢⼥ྜ䛧䛶㐍䜑䚸䛭䛾⑓ᅉ䞉⑓ែ䜢᫂䜙䛛䛻䛧䛶἞⒪ἲ䛾㛤Ⓨ䛻⤖
䜃䛴䛡䜛䚹

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մ ࡇ࡝ࡶࡢ⬻ࡢⓎ㐩࡜௒᪥䛾་⒪䛾㐍Ṍ䛻䜒䛛䛛䜟䜙䛪䚸⬻Ⓨ㐩㞀ᐖ䛾Ⓨ⏕㢖ᗘ䛿ῶᑡ䛧䛶䛚䜙䛪䚸ᗈỗᛶⓎ㐩㞀ᐖ䠄⮬㛢⑕䠅䜔ὀពḞ㝗ከືᛶ㞀ᐖ䠄㻭㻰㻴㻰䠅䛺䛹䛾⬻Ⓨ㐩㞀ᐖ䛾ゎ᫂䛿䚸ᑡᏊ໬♫఍䜢㏄䛘䛯᪥ᮏ䛻䛚䛔䛶䛿ႚ⥭䛻ゎỴ䛩䜉䛝ㄢ㢟䛷䛒䜛䚹䜎䛯䚸ᑠඣ⚄⤒⑌ᝈ䛿䚸⬻⅖䚸㛗ᮇ⒪⫱䜢క䛖▱ⓗ㞀ᐖ䚸⬻ᛶ㯞⑷䚸㔜⑕ᚰ㌟㞀ᐖ䚸䛶䜣䛛䜣䚸ᑠඣ⬻⭘⒆䚸௦ㅰ␗ᖖ⑕䛺䛹ከᵝ䛷䛒䜚䚸἞⒪ἲ䜒ෆ⛉ⓗ἞⒪䛛䜙⬻እ⛉ⓗ἞⒪䜎䛷ከᒱ䛻䜟䛯䜛䛜᰿἞ⓗ἞⒪ἲ䛿☜❧䛧䛶䛔䛺䛔䚹䛣䛾䛯䜑䚸ᶵ⬟⏬ീⓗ䚸⑓ែ་Ꮫⓗ䚸デ᩿⑓⌮Ꮫⓗ䚸⏕⌮Ꮫⓗ䛺◊✲䜢᥎㐍䛧䚸᪂䛯䛺἞⒪ἲ䞉䝸䝝䝡䝸䝔㻌䞊䝅䝵䞁ἲ䛾㛤Ⓨ䜢┠ᣦ䛩䚹䜎䛯䚸⬻䛾ᙧᡂ䜢ไᚚ䛩䜛㑇ఏᏊᶵ⬟䜔䚸䛶䜣䛛䜣Ⓨస䛺䛹䛾άື䛻౫Ꮡⓗ䛺㑇ఏᏊ䞉ศᏊᶵᵓ䛾ゎ᫂䛾䛯䜑䛾◊✲䜢⾜䛔䚸㠉᪂ⓗ䛺་⒪䛾㛤Ⓨ䜢䜑䛦䛩䚹㻌－ 1 －䖂䝫䝸䜸䝽䜽䝏䞁᳨ᐃ䝬䜴䝇䛾㛤Ⓨ䖂㻯 ᆺ⫢⅖䜴䜲䝹䝇⢏Ꮚ䛾ྠᐃ䖂䜲䞁䝍䞊䝣䜵䝻䞁἞⒪ຠᯝண ἲ䛾☜❧
䖂ᐟ୺ᅉᏊ䜢ᶆⓗ䛻䛧䛯ᢠ 㻯ᆺ⫢⅖䜴䜲䝹䝇๣䛾㛤Ⓨ䖂䝟䞊䜻䞁䝋䞁⑓䛻䛚䛡䜛⣽⬊Ṛ㜼Ṇἲ䛾㛤Ⓨ䖂䃑䜰䝭䝻䜲䝗䛻ᑐ䛩䜛 㻰㻺㻭䝽䜽䝏䞁䛾㛤Ⓨ䖂ㄆ▱⑕䛸 㻭㻸㻿 䛻ඹ㏻䛩䜛
ཎᅉ⺮ⓑ㉁␗ᖖ䜢Ⓨぢ䛧䚸⑓ែ䜢ゎ᫂䖂䛶䜣䛛䜣Ⓨసᚋ䛾グ᠈㞀ᐖ䛾䝯䜹䝙䝈䝮ゎ᫂䖂㞴἞ᛶ䛶䜣䛛䜣䛾ᡭ⾡⒪ἲ㛤Ⓨ䜈䛾ᐤ୚
䖂㓟໬䝇䝖䝺䝇䛸⬻Ⓨ㐩㞀ᐖ䛾㛵ಀ䜢ゎ᫂

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◊✲ࡢᚲせᛶյ ᚰࡢ⑓ࡢ ཎᅉ✲ ᫂⢭⚄ࡢ㻌 ྛ✀䛾⢭⚄㞀ᐖ䠄Ẽศ㞀ᐖ䚸୙Ᏻ䞉䝇䝖䝺䝇ᛶ㞀ᐖ䚸⤫ྜኻㄪ⑕䚸≀㉁౫Ꮡ䚸╧╀㞀ᐖ䛺䛹䠅䛻ᑐ䛧䛶䚸㑇ఏᏛⓗ䞉ศᏊ⏕≀Ꮫⓗᡭἲ䛻䜘䜛ཎᅉ✲᫂䛾䛯䜑䛾◊✲䜢㐍ᒎ䛥䛫䜛䚹ྛ⑓ែ䛻䛚䛔䛶䚸㑇ఏᏊከᆺ䜔ೃ⿵㑇ఏᏊ䞉㛵㐃㑇ఏᏊ䛾ゎᯒ䚸Ṛᚋ⬻䜔⏕యヨᩱ䜢⏝䛔䛯⏕໬Ꮫⓗゎᯒ䚸⏕≀Ꮫⓗ⬤ᙅᛶ䛻㛵䛩䜛ศᏊ䞉⣽⬊䝺䝧䝹䛾ゎᯒ䚸㑇ఏᏊᨵኚ䝬䜴䝇䜢⏝䛔䛯⾜ື䝺䝧䝹䛾ゎᯒ䛺䛹䛻䜘䜚䚸ཎᅉཬ䜃ᇶ♏䝯䜹䝙䝈䝮䜢ゎ᫂䛩䜛䚹䛒䜟䛫䛶⬻Ἴ䜔⮬ᚊ⚄⤒άື䛺䛹䛾⢭⚄⏕⌮Ꮫⓗᣦᶆ䛾ศᯒ䜔䚸䝙䝳䞊䝻䜲䝯䞊䝆䞁䜾ᡭἲ䛻䜘䜛⑓ែゎ᫂䛚䜘䜃἞⒪ᣦᶆ䜔᪩ᮇデ᩿䛻ᙺ❧䛴◊✲䜢㐍䜑䜛䚹䛥䜙䛻᪂つ⸆๣䛾㛤Ⓨ䜔䚸⑓ែ䛻ᙳ㡪䛩䜛ᰤ㣴⣲䛾◊✲䚸ື≀䝰䝕䝹䛻䜘䜛ೃ⿵἞⒪⸆ᶆⓗศᏊ䛾స⏝ᶵᗎ䛾ゎᯒ䛺䛹
䜢㏻䛨䛶䚸䜸䞊䝎䞊䝯䜲䝗䛾἞⒪ἲ䜔ண㜵ἲ䛾ᐇ⌧䜢䜑䛦䛩䚹㞀ն ᚰࡢ೺ᗣ࡙ࡃࡾᐖ㻌 ᑡᏊ㧗㱋໬䚸⤒῭䜔ᩥ໬䛾䜾䝻䞊䝞䝹໬䚸᝟ሗ䜔䝁䝭䝳䝙䜿䞊䝅䝵䞁䛾㻵㼀㻌໬䛿䚸♫఍ᵓ㐀䛸ಶே䛾ព㆑䜢ኚᐜ䛥䛫䚸ᐙᗞ䚸⫋ሙ䚸Ꮫᰯ䚸ᆅᇦ䛾⎔ቃ䛻኱䛝䛺ኚ໬䜢䜒䛯䜙䛧䛶䛔䜛䚹䛭䜜䛻㛵㐃䛧䛶⏕䛨䜛䝇䝖䝺䝇䜔ⴱ⸨䛿ಶே䛾䝯䞁䝍䝹䝦䝹䝇୙ㄪ䛻䛴䛺䛜䜚䜔䛩䛟䚸䝯䞁䝍䝹䜿䜰䛾඘ᐇ䛜ᚲせ䛸䛥䜜䜛䚹ලయⓗၥ㢟䛸䛧䛶䚸䛯䛸䛘䜀⮬ẅ䜔䛖䛴⑓䛾ቑຍ䚸⶝ᘏ䛩䜛⸆≀஘⏝䚸ඣ❺ᛮ᫓ᮇ䛾୙㐺ᛂ䜔ၥ㢟⾜ື䚸ᚰⓗ䝖䝷䜴䝬䛜䜒䛯䜙䛩㻼㼀㻿㻰㻌㛵㐃㞀ᐖ䚸ྖἲ⢭⚄་Ꮫⓗㄢ㢟䛸䛧䛶䛾ຍᐖ⾜ື䛾⑓⌮➼䛿䚸᪂䛯䛺䝯䞁䝍䝹䝦䝹䝇䝥䝻䝰䞊䝅䝵䞁䛾䛒䜚᪉䛾◊✲䜢ồ䜑䛶䛔䜛䚹䛭䛾┠ⓗ䛻ྥ䛡䛶䚸䜶䝡䝕䞁䝇䜢㔜ど䛧䛯ᐇドⓗ◊✲ᡭἲ䛻䜘䜚䚸␿Ꮫⓗᐇែ䚸ຠᯝⓗ䛺἞⒪䞉௓ධ䜔ண㜵ᩍ⫱䛻䛴䛔䛶䛒䛝䜙䛛䛻䛧䚸ᮃ䜎䜜䜛ไᗘ䜔ᨻ⟇䛾ᐇ⌧䛻䜒ᐤ୚䛩䜛䛣䛸䜢䜑䛦䛩䚹㻌շ ┳ㆤ ௓
㺃ㆤࢣ࢔࡜ࣜࣁࣅࣜ⒪㣴⪅࣭㞀ᐖ⪅ࡢࢣ࢔㻌 ⬻⾑⟶㞀ᐖ䚸䛜䜣䚸⚄⤒䞉➽⑌ᝈ䚸⢭⚄⑌ᝈ䛻క䛖ṧ㑇⑕≧䜔ᶵ⬟㞀ᐖ䜢ཎᅉ䛸䛧䛯೺ᗣၥ㢟䜔᪥ᖖ⏕ά䛾ᨭ㞀䜢㍍ῶ䛩䜛䛣䛸䛿䚸㞀ᐖ䛻ⱞ䛧䜐ே䚻䛾䠭䠫䠨䠄⏕ά䛾㉁䠅䛾ྥୖ䛻䛸䛳䛶ᚲ㡲䛷䛒䜛䚹䛣䛾◊✲ㄢ㢟䛷䛿䚸䛭䛾┠ⓗ䛻ྥ䛡䛶䚸䜘䜚䜘䛔┳ㆤ䞉௓ㆤἲ䚸䝸䝝䝡䝸ἲ䚸௦᭰ἲ䜔⦆࿴䜿䜰ἲ䛾㛤Ⓨ䜢┠ᣦ䛩◊✲䜢᥎㐍䛩䜛䚹䛺䛛䛷䜒䚸㠀౵くⓗேᕤ࿧྾ἲ
䠄㻺㻼㻼㼂䠅䛺䛹⒪㣴⪅䛸௓ㆤ⪅䛻㈇ᢸ䛜ᑡ䛺䛟Ᏻ඲䛺┳ㆤᨭ᥼ἲ䜔ᅾᏯ་⒪⟶⌮ἲ䛾㛤Ⓨ䚸ᆅᇦ䛷⏕ά䜢Ⴀ䜐㞀ᐖ⪅䛾♫఍᚟ᖐ䡡♫఍ཧຍ䛾ᨭ᥼䛾඘ᐇ䚸ಖ೺䞉་⒪䞉⚟♴䛜㐃ᦠ䛧䛯㈝⏝ᑐຠᯝ䛾㧗䛔䝃䞊䝡䝇ᥦ౪యไ䛾☜❧䛺䛹䜢┠ᣦ䛧䛯◊✲䜢ᒎ㛤䛩䜛䚹䜎䛯䚸ᑓ㛛་⒪ᶵ㛵䛸㐃ᦠ䛧䛶䚸ᐈほⓗ䛺ᣦᶆ䛻ᇶ䛵䛟┳ㆤ䞉௓ㆤ䛾ホ౯䝅䝇䝔䝮䜢⏝䛔䛯ᐇドⓗ䛺ㄪᰝ◊✲䜢⾜䛖䚹䛥䜙䛻䚸㧗ḟ⬻ᶵ⬟䚸㐠ື䞉ឤぬ䝅䝇䝔䝮䚸⢭⚄⑌ᝈ⑓ែ➼䛻㛵䛩䜛⚄⤒⛉Ꮫ◊✲䛛䜙ᚓ䜙䜜䛯᪂▱ぢ䜢䝸䝝䝡䝸䝔䞊䝅䝵䞁䛾⌧ሙ䛷ά⏝䛩䜛䛯䜑䛾᪂䛧䛔⿦⨨䜔ᡭἲ㛤Ⓨ䛾◊✲䜢᥎㐍䛩䜛䚹ո ⺮ⓑ㉁ࡢ௦ㅰ࡜⑌⑓

⺮ⓑ㉁䛿⣽⬊䛾ቑṪ䜔ศ໬䛺䛹⏕࿨άື䛾ᇶ┙䜢ྖ䛳䛶䛚䜚䚸㓝⣲䚸⣽⬊㦵᱁䚸㌿෗ᅉᏊ䚸ཷᐜయ䛺䛹ከ✀ከᵝ䛺ᶵ⬟䜢ᣢ䛴䚹ᚑ䛳䛶⺮ⓑ㉁䛾◚⥢䛿䚸ᝏᛶ⭘⒆䚸䝯䝍䝪䝸䝑䜽⑕ೃ⩌䚸⮬ᕫච␿⑌ᝈ䚸➽⑌ᝈ䚸⚄⤒ኚᛶ⑌ᝈ䛺䛹ᵝ䚻䛺⑓ែ䜢ᘬ䛝㉳䛣䛩䚹⑌ᝈ䛾デ᩿䞉἞⒪䞉ண㜵䛾䛯䜑䛻䛿䚸䛣䜜䜙⺮ⓑ㉁䛾ᵓ㐀䛸ᶵ⬟䜢ศᏊ䝺䝧䝹䛷ゎ᫂䛧䚸⺮ⓑ㉁䛾ᶵ⬟୙඲䛻䜘䜛⑓ែⓎ⑕ᶵᗎ䛾ศᏊ䝯䜹䝙䝈䝮䜢᫂☜䛻䛩䜛䛣䛸䛜ᴟ䜑䛶㔜せ䛷䛒䜛䚹඲䛶䛾⺮ⓑ㉁䛿༓ᕪ୓ู䛾ᑑ࿨䜢䜒䛳䛶䝍䞊䞁䜸䞊䝞䞊䛧䛶䛚䜚䚸䛭䛾㛫䛻䝸䞁㓟໬䚸䝴䝡䜻䝏䞁໬䚸䝨䝥䝏䝗㙐ษ᩿䚸䛺䛹ᶵ⬟ኚ᥮䛾䛯䜑䛾ᵝ䚻䛺⩻ヂᚋಟ㣭䜢ཷ䛡䜛䚹䛧䛛䛧䚸⺮ⓑ㉁䛾௦ㅰ䝅䝇䝔䝮䚸⢾䞉⬡㉁䛾ྜᡂ䞉ศゎ䛻㛵୚䛩䜛㓝⣲ᶵ⬟䚸䛥䜙䛻䚸⺮ⓑ㉁䛸௚䛾⏕యศᏊ䛸䛾┦஫స⏝䛻䜘䜛᝟ሗఏ㐩䛾䝯䜹䝙䝈䝮䛺䛹⺮ⓑ㉁䛾స⏝䛾኱㒊ศ䛜ᮍ▱䛾䜎䜎䛷䛒䜛䚹䛭䛣䛷ᮏ◊✲ㄢ㢟䛷䛿䚸⏕໬Ꮫ䚸䝥䝻䝔䜸䞊䝮䚸ศᏊ⏕≀Ꮫ䚸⣽⬊⏕≀Ꮫ䚸ᵓ㐀⏕≀Ꮫ䚸㑇ఏᏛ䛺䛹䛾᭱ඛ➃ᢏ⾡䜢㥑౑䛧
䛶䚸⺮ⓑ㉁䛜⏕࿨άື䛻䛚䛔䛶ᯝ䛯䛩ᙺ๭䜢ゎ᫂䛧䚸䛭䛾సືཎ⌮䛻㛵䛩䜛᪂䛧䛔ᴫᛕ䛾๰ᡂ䜢䜑䛦䛩䚹㻌－ 2 －ࡇࢀࡲ࡛ࡢ◊✲ᡂᯝ䖂⤫ྜኻㄪ⑕䛾Ⓨ⑕ཎᅉ㑇ఏᏊ䛾Ⓨぢ䖂㑇ఏᏊゎᯒ䛻䜘䜛⸆≀ឤཷᛶண ἲ䛾㛤Ⓨ䖂㐣╀⑕䛾⑓ែ䛻㛵୚䛩䜛㑇ఏᏊ䛾Ⓨぢ䖂㻼㼀㻿㻰 デ᩿ᑻᗘ䛾㛤Ⓨ䛸ᬑཬ䖂౫Ꮡ⑕デ᩿ᑻᗘ䛾㛤Ⓨ䛸ᬑཬ䖂ẕぶ䛾䝯䞁䝍䝹䝦䝹䝇䛸Ꮚ⫱䛶ᨭ᥼䖂㻭㻸㻿 䛾ᅾᏯேᕤ࿧྾ჾ⒪ἲ䛾☜❧䛸ไᗘ໬䜈䛾㈉⊩䖂኱⬻༙⌫ᦆയᚋ䛾㧗ḟ⬻ᶵ⬟㞀ᐖ䛾デ᩿ἲ䛾☜❧䖂➽άື䛾ᐃ㔞ⓗゎᯒ䛻䜘䜛㐠ືᶵ⬟ホ౯ἲ䛾㛤Ⓨ䖂⤫ྜኻㄪ⑕⌮ゎ䛾䛯䜑䛾ᮏே䞉ᐙ᪘ྥ䛡 㻰㼂㻰 ᩍᮦ䛾㛤Ⓨ䛸ᬑཬ䖂⣽⬊ᛶච␿䛻䛚䛡䜛䝥䝻䝔䜰䝋䞊䝮䛾ᙺ๭䛾ゎ᫂䖂⚄⤒⣽⬊䛾⮬㣗స⏝䛜䚸⚄⤒ኚᛶ⑌ᝈ䛾Ⓨ⑕䜢㣗䛔Ṇ䜑䜛䖂⤌⧊≉␗ⓗ䜹䝹䝟䜲䞁䛾᪂䛧䛔స⏝ᶵᗎ䛾Ⓨぢ䖂䝸䞁⬡㉁௦ㅰ㓝⣲䛾⏕⌮ⓗ
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◊✲ࡢᚲせᛶչ ⏕య㜵ᚚ ࡢ࣓࢝ ࢽࢬ࣒ⰼ⢊⑕䞉Ẽ⟶ᨭႍᜥ䞉䜰䝖䝢䞊ᛶ⓶⭵⅖䛿䚸㒔ෆ䛷䜒ᝈ⪅ᩘ䛾ከ䛔⑌ᝈ䛷䛒䜛䚹䜎䛯䚸Ḣ⡿ᆺ䛾㣗⏕ά䛻䜘䜛䝯䝍䝪䝸䝑䜽⑕ೃ⩌䜒ᖺ䚻῝้໬䛧䛶䛔䜛䚹䛣䛾䜘䛖䛺䜰䝺䝹䜼䞊ᛶ⑌ᝈ䜔⏕ά⩦័⑓䛿䚸㼀 ⣽⬊䚸⫧‶⣽⬊䚸⬡⫫⣽⬊➼䛾ㄪ⠇␗ᖖ䛻㉳ᅉ䛩䜛䛯䜑䚸䜎䛪㈐௵⣽⬊䛾ቑṪ䞉ศ໬䞉ືဨ䛾ศᏊᶵᵓ䜢᫂䜙䛛䛻䛩䜛ᚲせ䛜䛒䜛䚹୍᪉䚸ෆⓗせᅉ䛻䜘䛳䛶䛚䛣䜛⮬ᕫච␿⑌ᝈ䚸௦ㅰ␗ᖖ䚸㞴἞ᛶ⮚ჾኚᛶ⑌ᝈ䛾౛䜒ከ䛔䚹䛣䜜䜙䜢ඞ᭹䛩䜛䛻䛿䚸◚⥢䛧䛯⣽⬊ᶵ⬟䛸㈐௵ศᏊ䛸䜢ྠᐃ䛧䚸䛣䜜䜙䜢⸆≀ᢞ୚䜔⣽⬊⛣᳜䛻䜘䛳䛶ṇᖖ໬䛥䛫䛺䛡䜜䜀䛺䜙䛺䛔䚹⤌⧊ᖿ⣽⬊䜔㼕㻼㻿 ⣽⬊䜢⏝䛔䛯෌⏕་⒪ἲ䜒⪃៖䛥䜜䜛䜉䛝䛷䛒䜛䚹ᮏ◊✲ㄢ㢟䛷䛿䚸⏕య㜵ᚚ䛾䝯䜹䝙䝈䝮䜢ಶయ䞉⣽⬊䞉ศᏊ䝺䝧䝹䛷◊✲䛧䚸䛭䜜䜙䛾◚⥢䛻㉳ᅉ䛩䜛ྛ✀⑌ᝈ䛾἞⒪ἲ䞉ண㜵ἲ䛾㛤Ⓨ䜢䜑䛦䛩䚹㻌պ ⑌⑓ࡢ㑇 ఏᏛ

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䛾㛤Ⓨ䛾䛯䜑䛾◊✲䜢᥎㐍䛩䜛䚹䜎䛯䚸኱⬻䜢୰ᚰ䛸䛧䛯ྛ㧗ḟ⬻ᶵ⬟䛾䝅䝇䝔䝮ⓗゎᯒ䛻ຍ䛘䛶䚸⚄⤒⣽⬊㛫䛾ఏ㐩ᶵᵓ䚸⣽⬊ෆศᏊᶵᵓ
䛾ゎᯒ䚸ᶵ⬟㑇ఏᏊཬ䜃⾜ື㑇ఏᏛⓗゎᯒ䜢⾜䛺䛖䚹⬻⾑ὶ䜔䜶䝛䝹䜼䞊௦ㅰ䜢ᣦᶆ䛻䛧䛯䚸⬻ᶵ⬟䜢⏬ീ໬䛩䜛᪂䛧䛔ᢏ⾡䜢ᛂ⏝䛧䛶䚸᪂つⓗ䛺デ᩿䞉἞⒪ἲ䛾㛤Ⓨ䛾䛯䜑䛾◊✲䜒㐍䜑䜛䚹㻌䖂⚄⤒ẘ䜢฼⏝䛩䜛䝅䝘䝥䝇ఏ㐩ᶵ⬟䛾ゎ᫂㻌㻌䖂ពḧ䜔ືᶵ௜䛡䛾⬻ෆ䝯䜹䝙䝈䝮䛾ゎ᫂㻌㻌䖂グ᠈㞀ᐖ䛻㛵୚䛩䜛㑇ఏᏊ䛾Ⓨぢ㻌㻌䖂᪂䛧䛔⬻άືィ ἲ䛾㛤Ⓨ㻌ே䛾⾜ື䜢䝝䞊䝗䜴䜵䜰ⓗ䛻ᨭ䛘䜛㐠ື䝅䝇䝔䝮䠄㐠ື⓶㉁㐃ྜ㔝䚸ᇶᗏ᰾䚸ᑠ⬻䚸⬻ᖿ䞉⬨㧊䛾㐠ື⚄⤒᰾䚸ᮎᲈ⚄⤒䞉➽䠅䚸䛚䜘䜃ឤぬ䝅䝇
䝔䝮䠄どぬ䞉⫈ぬ䞉࿡ぬ䞉Ⴅぬ䞉యᛶឤぬ䠅䜢䝅䝇䝔䝮䝺䝧䝹䛛䜙ศᏊ䝺䝧䝹䜎䛷䛾ከᒙⓗ䞉」ྜⓗ䜰䝥䝻䞊䝏䛷◊✲䛧䚸䛭䛾ᶵ⬟㞀ᐖ䛾ඞ᭹䜢ᅗ䜛䚹≉䛻䚸኱⬻䠉ᑠ⬻䠉ᇶᗏ᰾㐃㛵䛻䛚䛡䜛᝟ሗฎ⌮ᶵᵓ䜢ゎ᫂䛩䜛◊✲䜢᥎㐍䛧䚸㐠ືኻㄪ䜢䛝䛯䛩⑌ᝈ䠄䝟䞊䜻䞁䝋䞁⑓䚸⬨㧊ᑠ⬻ኚᛶ⑕䛺䛹䠅䛷ぢ䜙䜜䜛㐠ື䝅䝇䝔䝮␗ᖖ䛾⑓ែゎ᫂䜔἞⒪ἲ㛤Ⓨ䜢┠ᣦ䛩䚹䜎䛯䚸⬻⾑⟶㞀ᐖ䚸⬻⬨㧊ᦆയ䚸⢾ᒀ⑓䜔㑇ఏᛶ䝙䝳䞊䝻䝟䝏䞊䚸⚄⤒⅖䛺䛹䛾ᮎᲈ⚄⤒㞀ᐖ䚸➽⑌ᝈ䚸どᶵ⬟㞀ᐖ䛺䛹䛾⑓ែ䚸䛚䜘䜃䝨䜲䞁䝁䞁䝖䝻䞊䝹䜔ឤぬᶵᵓ䛾ゎ᫂䛾䛯䜑䛾◊✲䜢⾜䛖䚹䛭䜜䜙䛻䜘䜚䚸㑇ఏᏊ἞⒪䜔⣽⬊⛣᳜἞⒪䚸䝤䝺䜲䞁䝬䝅䞁䜲䞁䝍䞊䝣䜵䞊䝇䜢㥑౑䛧䛯䝃䜲䝞䞊་⒪➼䛾㠉᪂ⓗ་⒪䛾ᐇ⏝໬䛻䜒✚ᴟⓗ䛻ྲྀ䜚⤌䜣䛷䛔䛟䚹㻌䖂㝶ព㐠ື᫬䛻䛚䛡䜛⬨㧊䛾㐠ືไᚚᶵᵓ䛾ゎᯒ㻌㻌䖂୙㝶ព㐠ື䛾⚄⤒ᅇ㊰ᶵ⬟䛾ゎ᫂㻌㻌䖂ṇᖖ║ᅽ⥳ෆ㞀䛾Ⓨ⑕䝯䜹䝙䝈䝮䛾ゎ᫂㻌

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͗Ξ͵ʹ͹࣮‫׳‬Ͷ‫ؖ‬࿊ͤΖΰόϞߑଆ͹ଡ ࡜ࡶ࡟ࠊᰁⰍయࡢ」〇࣭ፉ⣽⬊࡬ࡢศ㓄࡞࡝ࠊࢤࣀ࣒ࡢ⥅ zࣄࢺ⣽⬊࠿ࡽ⣽⳦࡟ࡲ࡛ಖᏑࡉࢀࡿࢤࣀ࣒
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ᝈࡢཎᅉ࡜࡞ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࢤࣀ࣒⥔ᣢ࣭⥅ᢎ ࡸࢤࣀ࣒ୖࡢ≉Ṧᵓ㐀ࡢ⏕⌮ⓗព⩏ࢆゎ᫂ࡢせ࡜࡞ࡿࢤࣀ࣒」〇࡜ࡑࡢไᚚᶵᵓࠊཬࡧࢤࣀ࣒ࡢከᵝ ࡍࡿࠋ࡞ᵓ㐀ࡸࡑࡢไᚚᅉᏊࡢ⏕⌮ⓗព⩏ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼ
zᚓࡽࢀࡿᇶ♏ⓗ࡞▱ぢ࡟ᇶ࡙ࡁࠊไࡀࢇࡢ
ࡾࠊࢤࣀ࣒ࡢኚ໬ࡀ⑌ᝈࡢⓎ⏕࡜࠸࠿࡟㛵ࢃࡿ࠿ࢆゎ᫂᪂つデ᩿࣭἞⒪ᡓ␎ࢆᵓ⠏ࡍࡿࠋࡋࠊ᪂つࡢデ᩿ࠊ἞⒪ἲࡢ㛤Ⓨ࡟ᛂ⏝ࡍࡿࡇ࡜ࢆࡵࡊࡍࠋ ့ங㢮⑌ᝈࣔࢹࣝື≀ࡣ㑇ఏᏛ◊✲࡟ࡼࡗ࡚ከࡃࡢ⑌ᝈz့ங㢮ࣔࢹࣝື≀ࡢ฼⏝࡟ࡼࡗ࡚⑓ẼࡢⓎᄣ೗ྪҪఽָΝ‫خ‬൭ͳ࣮ͪ͢‫׳‬͹‫ݬ‬Ҿմ໎ࡢཎᅉゎ᫂࡟㈉⊩ࡋ࡚ࡁࡓࠋࡋ࠿ࡋࠊ௒࡞࠾ከࡃࡢ⑌ᝈ࡟
⑕࡜㑇ఏᏊ␗ᖖ࡜ࡢ㛵ಀࢆゎ᫂ࡋࠊ㑇ఏᏊ㛵ಀࡉࢀ࡚࠸ࡿ㑇ఏⓗཎᅉࡣ༑ศゎ᫂ࡉࢀ࡚࠸࡞࠸ࠋࡇࢀ
デ᩿ࡸ⑓Ẽࡢண㜵࣭἞⒪࡟ᙺ❧ࡘ㑇ఏ᝟ሗࡽࡢࣔࢹࣝື≀ࡣ⑓ែ⌮ゎࠊ᪂⸆ホ౯ࡢࡓࡵ࡟ࡶᚲ㡲࡛࠶ࢆ⵳✚ࡍࡿࠋ٤ઔ‫ ྆ۏ‬ᄣ೗ྪҪఽϕϫζΥέφࡾࠊࡑࡢ㛤Ⓨࡣ㔜せ࡞◊✲ㄢ㢟࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛
zࣄࢺࡢ⑓ែホ౯ࡸࠊ᪂ࡓ࡞⸆࣭ᶵ⬟ᛶ㣗ရࡣࠊゎᯒᅔ㞴࡞ࣄࢺࡢ⑌ᝈࡢ⑓ែゎ᫂࡟ᙺ❧ࡘࣔࢹࣝື≀ࡢ㛤Ⓨ࡬㈉⊩࡛ࡁࡿ့ங㢮ࣔࢹࣝື≀ࢆᶞࢆᶞ❧ࡋࠊ㡰㑇ఏᏛⓗゎᯒ࡟ࡼࡿࡇࢀࡽࡢⓎ⑕ཎᅉࡢゎ᫂
0DPPDOLDQ*HQHWLFV3URMHFW❧ࡍࡿࠋࢆࡵࡊࡍࠋ
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ࡀࠊᮾி࡞࡝ࡢ㉸ேཱྀᐦ㞟ᆅ࡛ὶ⾜ࡋࡓሙྜ࡟ࡣࠊࡑࡢேzᏘ⠇ᛶ࢖ࣥࣇ࢚ࣝࣥࢨࠊ᪂ᆺ࢖ࣥࣇ࢚ࣝࣥ
η‫״‬ઝ঳͹༩๹ͳ࣑ྏ
ⓗ࣭♫఍ⓗ⿕ᐖࡣ᝿ീࢆ⤯ࡍࡿࡶࡢ࡜࡞ࡿࠋࡲࡓࠊࢃࡀᅜ
ࢨࡢ⑓ែࢆゎ᫂ࡋࠊண㜵࣭἞⒪ἲࡢ㛤Ⓨࢆ࡛ࡣࠊ% ᆺ⫢⅖࢘࢖ࣝࢫࠊ& ᆺ⫢⅖࢘࢖ࣝࢫឤᰁࡀ⫢ࡀࢇ
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᫂ࡋࠊ἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ
࢙ࢡࢺ࡛ࡣࠊ᪂ᆺࢆྵࡴࡍ࡭࡚ࡢ $ ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖
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ࡶ࡟ࠊ࢘࢖ࣝࢫᛶ⫢⅖ࡢ἞⒪࣡ࢡࢳࣥࡢ㛤Ⓨࢆࡵࡊࡍࠋ
ᅜෆእ࡟࠾࠸࡚࢘࢖ࣝࢫࡢὶ⾜࡟ࡼࡾ೺ᗣ⿕ᐖࡸ♫఍ⓗΤ΢ϩη‫״‬ઝ͹ϟΩωθϞͶ‫ᦆ῭⤒ ྏ࣑ͪ͏Ͱخ‬ኻࡀⓎ⏕ࡋ࡚࠸ࡿࠋ࢘࢖ࣝࢫࡣᐟ୺ࡢ୰࡛」〇ࡋ࡚༂౵͹֋൅

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෾ࢢҫྏϕϫζΥέφ
0ROHFXODU0HGLFDO5HVHDUFK3URMHFW೟எ঳͹൅঳ͳ਒ߨ‫ؽ‬঄͹մ໎̕ ௗ୫ઔ੔ਕ ೟எ঳ϕϫζΥέφ'HPHQWLD5HVHDUFK3URMHFWָस‫ى‬Գ‫ߑؽ‬͹‫ݬ‬ཀྵͳ্֒͹մ໎̖ᴣ౽ ࣰ ָस‫ى‬ԳϕϫζΥέφ/HDUQLQJDQG0HPRU\3URMHFWz࢚ࣥࢸࣟ࢘࢖ࣝࢫ  ࡢ⑓ཎᛶࢆᨭ㓄ࡍࡿ⑓Ẽࢆᘬࡁ㉳ࡇࡍࡇ࡜࠿ࡽࠊ࢘࢖ࣝࢫഃ࡞ࡽࡧ࡟ᐟ୺ഃࡢ
࢘࢖ࣝࢫഃせᅉ࡜ᐟ୺ഃࡢせᅉࢆゎ᫂ࡍ୧᪉ࡢせᅉࢆゎᯒࡋࠊࡑࡢண㜵ࡸ἞⒪ࡢᑐ⟇ࢆ❧࡚ࡿࡇ࡜ࡿࠋࡀ㔜せ࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ㏆ᖺ࢔ࢪ࢔࡛኱ὶ⾜ࡀz࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢ 51$ ࣏࣓࣮ࣜࣛ
ぢࡽࢀ࡚࠸ࡿ࢚ࣥࢸࣟ࢘࢖ࣝࢫࠊ࡞ࡽࡧ࡟࢖ࣥࣇ࢚ࣝࣥࢨ
ࢮάᛶࢆ㜼ᐖࡍࡿᢠ࢖ࣥࣇ࢚ࣝࣥࢨ⸆ࡢ㛤࢘࢖ࣝࢫࢆྲྀࡾୖࡆࠊࡇࢀࡽࡢ࢘࢖ࣝࢫࡢ」〇ࡢ࣓࢝ࢽࢬ
Ⓨ➼ࢆࡵࡊࡍࠋ
࣒ࢆ᫂ࡽ࠿࡟ࡋࠊ἞⒪⸆ࡢ㛤Ⓨ➼࡟ࡘ࡞ࡀࡿ◊✲ࢆᒎ㛤ࡍࡿࠋ㒔Ẹࡢ  ࡀࡾᝈࡋ࡚࠸ࡿࢫࢠⰼ⢊⑕ࡣࠊ᰿ᮏ἞⒪ἲ࡜
z࢔ࣞࣝࢠ࣮⑌ᝈࡢ⑓ែᙧᡂ࣓࢝ࢽࢬ࣒࡜ච
ࡋ࡚⯉ୗච␿⒪ἲࡀಖ㝤㐺⏝ࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽච␿⒪␿⒪ἲࡢస⏝࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋἲࡢ᭷ຠᛶࡣ⣙༙ศ⛬ᗘ࡛࠶ࡾࠊ࢔ࣞࣝࢠ࣮἞⒪ࡣ౫↛࡜z⯉ୗච␿⒪ἲ࡟࠾ࡅࡿ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡋ࡚ᢠ࢔ࣞࣝࢠ࣮⸆➼ࡢᑐ⑕⒪ἲࡀ୰ᚰ࡛࠶ࡿࠋᮏࣉࣟࢪ
ࢆ☜❧ࡍࡿࠋ
࢙ࢡࢺ࡛ࡣࠊ࢔ࣞࣝࢠ࣮ච␿⒪ἲࡢస⏝࣓࢝ࢽࢬ࣒ࢆゎ᫂z⮫ᗋᛂ⏝࡛ࡁࡿ࢔ࣞࣝࢠ࣮᪂つ἞⒪ἲࡸ᪂
ࡋಶࠎࡢᝈ⪅࡟㐺ࡋࡓ᪤Ꮡ⒪ἲࡢᨵၿ࡜᪂つ⒪ἲࡢ㛤Ⓨࢆ⸆ࢆ㛤Ⓨࡍࡿࠋ
ࡵࡊࡍࠋ㧗㱋໬࡟ࡼࡿࡀࢇࡢቑຍ࡜ୡ⏺ⓗ࡞᪂⯆࣭෌⯆ឤᰁ⑕ࡢⓎ⏕ࡣࠊ⌧ᅾ኱ࡁ࡞♫఍ၥ㢟࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡ zࡀࢇ࣭ឤᰁ⑕ࢆ୰ᚰ࡜ࡋࡓศᏊᶆⓗࡢ᥈⣴ࢺ࡛ࡣࠊࡇࢀࡽࡢၥ㢟ࢆඞ᭹ࡍࡿࡓࡵ࡟ࠊࡀࢇࠊឤᰁ⑕ࢆ ࡜ゎᯒࢆ㐍ࡵࠊศᏊᶆⓗ࡟ࡼࡿデ᩿࣭἞⒪୰ᚰ࡟ࡋࡓ᪂つศᏊᶆⓗࡢ᥈⣴࡜ゎ᫂࡟ࡼࡿᇶ♏◊✲ࢆ᥎ ἲࢆ㛤Ⓨࡍࡿࠋ㐍ࡍࡿࠋ࠶ࢃࡏ࡚ࠊ⏘ᐁᏛ་㐃ᦠࡸ㒔❧⑓㝔➼࡜ࡢᶫΏࡋ z⏘ᐁᏛ་㐃ᦠ࡟ࡼࡿᶫΏࡋ◊✲ࢆ᥎㐍ࡍ◊✲ࢆ㐍ࡵ࡚ࠊḟୡ௦ࡢデ᩿ἲࡸᶵჾࠊ᪂ࡋ࠸἞⒪ἲ㛤Ⓨ ࡿࠋ࡞࡝ࡢᐇ⏝໬ࢆࡵࡊࡍࠋ
㤳㒔ᮾி࡟࠾࠸࡚ࡣ㉸㧗㱋໬ࡀ㐍ࡳࠊㄆ▱⑕ᑐ⟇ࡣᛴົ z๗᳨⬻ࡢ⚄⤒⑓⌮ࠊ⏕໬Ꮫゎᯒࢆ⾜࠸ࠊศ࡛࠶ࡿࠋᚎࠎ࡟⑓ែࡀ㐍⾜ࡍࡿ࢔ࣝࢶࣁ࢖࣐࣮⑓ࠊࣞࣅ࣮ Ꮚ⑓ែࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ᑠయᆺㄆ▱⑕ࠊ๓㢌ഃ㢌ⴥኚᛶ⑕࡞࡝ࡢㄆ▱⑕⑌ᝈ࡟ࡘ࠸ zᝈ⪅⑓ኚࢆ෌⌧ࡍࡿヨ㦂⟶ࠊ⣽⬊ࠊື≀࡚ࣔࡣࠊ᰿ᮏ἞⒪ἲࡣᮍࡔ࡟࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊゎ ࢹࣝࢆᵓ⠏ࡋࠊ⑓ែ㐍⾜ࢆᢚไࡍࡿ⸆๣ࡸ
᫂ࡉࢀ࡚࠸࡞࠸⬻ࡢ␗ᖖ⑓ኚࡢゎᯒࢆ㐍ࡵࠊ⑓ែࢆ෌⌧ࡍ ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋࡿヨ㦂⟶ࠊ⣽⬊ࠊື≀ࣔࢹࣝࢆᵓ⠏ࡋࠊ⑓ែ㐍⾜ࢆᢚ࠼ࡿ zᮏࣉࣟࢪ࢙ࢡࢺࢳ࣮࣒ࡀᥦၐࡋࡓఏ᧛௬ㄝ
ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋ⸆๣ࡸ἞⒪ἲࡢ㛤Ⓨࢆ┠ᶆ࡜ࡍࡿࠋ
zࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹ࡛ࣝᏛ⩦グ᠈ࢆᢸ࠺Ꮫ⩦グ᠈ࡣ⢭⚄άືࡢᇶ┙࡜࡞ࡿ㔜せ࡞⬻㧗ḟᶵ⬟࡛࠶㑇ఏᏊࢆྠᐃࡋࠊ᭱᪂ࡢ࢖࣓࣮ࢪࣥࢢ࣭ග
ࡾࠊ㐺ṇ࡞Ꮫ⩦グ᠈ຊࡢ⥔ᣢࡣ⏕άࡢ㉁ࡢ⥔ᣢ࡟ᚲせ࡛࠶᧯సᢏ⾡࡟ࡼࡾグ᠈㐣⛬ࡢྍど໬࡟ᣮࡴࠋ
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻ࡀ࡝ࡢࡼ࠺࡟ࡋ࡚ᚲせ࡞᝟ሗzࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹࣝ࠿ࡽᚓࡽࢀࡓ▱ぢࢆグ᠈ࡋ࡚ಖᣢࡋࠊᚲせ࡟ᛂࡌ࡚ㄞࡳฟࡍࡢ࠿ࢆࠊグ᠈ࢆࢆ့ங㢮ࣔࢹ᳨࡛ࣝドࡍࡿࡇ࡜࡟ࡼࡾᏛ⩦ᢸ࠺⚄⤒ᅇ㊰࡜ศᏊ⤒㊰ࡢാࡁ࠿ࡽ᫂ࡽ࠿࡟ࡍࡿࠋ࠶ࢃࡏ
グ᠈ࡢᇶᮏཎ⌮ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
࡚ྛ✀⢭⚄⚄⤒⑌ᝈࡸຍ㱋࡟ࡼࡾ⌧ࢀࡿグ᠈㞀ᐖࡢཎᅉࢆ
zࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࣔࢹࣝ࡜့ங㢮ࣔࢹ࡛ࣝศᏊ࣭ᅇ㊰࡛ࣞ࣋ࣝ᥈ࡾࠊࡑࡢᑐ⟇࡟㈨ࡍࡿᇶ┙᝟ሗࢆᥦࡢ┦⿵ⓗゎᯒ࠿ࡽྛ✀グ᠈㞀ᐖ⑓ែࡢศᏊ
౪ࡍࡿࠋᇶ┙࡜⚄⤒ᇶ┙ࢆᢳฟࡍࡿࠋ

－ 5 －

1R

ࣉࣟࢪ࢙ࢡࢺ
࣮ࣜࢲ࣮ࣉࣟࢪ࢙ࢡࢺྡ㸭␎⛠㸭ⱥㄒྡ೶੺ਹଝউ‫ޛ‬͹‫ؽ‬೵յ෰‫ؽ‬঄մ໎ͳ‫ؽ‬೵࠸‫ݒ‬๑͹֋൅

̗

੤ଞ߀஋

೶‫ؽ‬೵࠸‫ݒ‬ϕϫζΥέφ
1HXUDO3URVWKHVLV3URMHFW

ព ⩏

┠ ᶆ

᪥ᮏ࡟ࡣ  ୓ேࡢ⬨㧊ᦆയᝈ⪅ࠊ ୓ேࡢ⬻᱾ሰᝈ⪅zࢥࣥࣆ࣮ࣗࢱ࣮࢖ࣥࢱ࣮ࣇ࢙࢖ࢫᢏ⾡ࢆ⏝ࡀ࠾ࡾࠊࡇࢀࡽࡢ㯞⑷ࡋࡓ㐠ືᶵ⬟ࡸయไឤぬᶵ⬟ࢆྲྀࡾ࠸ࡓேᕤ⚄⤒᥋⥆࡟ࡼࡾࠊ⬻⬨㧊ᦆയᝈ⪅ᡠࡍࡓࡵࡢ㠉᪂ⓗ࡞἞⒪ᡓ␎ࡀᚅᮃࡉࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ
ࡢ㐠ືᶵ⬟ࢆ෌ᘓࡍࡿࠋ
࢙ࢡࢺ࡛ࡣࠊ୙἞ࡢ⑓࡛࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ⬻⬨㧊ᦆയzయᛶឤぬᶵ⬟ࡢ෌ᘓࢆᐇ⌧ࡍࡿேᕤ⚄⤒᥋ᝈ⪅ࡢ㝶ព㐠ືᶵ⬟࡜యໃឤぬᶵ⬟ࢆྲྀࡾᡠࡍ㠉᪂ⓗ࡞἞⥆ἲࢆ㛤Ⓨࡋࠊࡑࡢ᭷ຠᛶࢆ᳨ドࡍࡿࠋ⒪ἲࢆ㛤Ⓨࡋࠊ⬻⬨㧊ᦆയ࡟ࡼࡗ࡚ኻࡗࡓᶵ⬟࡛࠶ࡿ͆⮬zᚰ࡜㌟యࢆ⧅ࡄ⚄⤒ᇶ┙ࢆゎ᫂ࡋࠊࡑࢀ࡟
ศࡢ㌟యࢆឤࡌࠊ⮬ศ࡛ື࠿ࡍ͆ࡇ࡜ࢆ෌⋓ᚓࡍࡿࡇ࡜ࢆ
ᇶ࡙࠸ࡓᶵ⬟ᅇ᚟ಁ㐍ἲࢆ㛤ⓎࡍࡿࠋࡵࡊࡍࠋzⓎ㐩ᮇࡢ⬻ෆ⎔ቃࡢ⥔ᣢࡢࡓࡵ࡟㸪⚄⤒⣽ࡇ࡝ࡶࡢ⬻࡟ࡣ኱ேࡢ⬻࡟ࡣぢࡽࢀ࡞࠸⚄⤒⣽⬊ࡢࡳ࡞ ⬊ࡸࢢࣜ࢔⣽⬊ࡀྖࡿ⚄⤒ච␿ࡢᙺ๭ࢆゎࡽࡎࢢࣜ࢔⣽⬊ࡢᵝࠎ࡞ാࡁࡀ࠶ࡿࠋ⬻ࡀⓎ㐩ࡍࡿࡓࡵ࡟ ᫂ࡍࡿࠋࡣࠊࡇࢀࡽࡢႠࡳࡀṇᖖ࡟ไᚚࡉࢀࡿᚲせࡀ࠶ࡿࠋᮏࣉࣟ zࡇ࡝ࡶࡢ⬻࡟࠾ࡅࡿ⬻ෆ⎔ቃ⥔ᣢࡢࡓࡵࡢ
ࢪ࢙ࢡࢺ࡛ࡣࠊ୺࡟ච␿⣔ࡢどⅬ࠿ࡽࠊⓎ㐩ᮇࡢ⬻ෆ⎔ቃ ච␿⣔࡜㠀ච␿⣔ࡢࢿࢵࢺ࣮࣡ࢡࢆゎ᫂ࡍࠦ‫ʹ͞ ܔؔٳ‬΍͹೶ϕϫζΥέφࢆ⥔ᣢࡍࡿࡓࡵࡢ௙⤌ࡳ࡜ࠊࡑࡢ◚ࡓࢇ࡟ࡼࡿ⬻⅖࣭⬻⑕ ࡿࠋ࡞࡝ࠊࡇ࡝ࡶࡢ⬻⑌ᝈࡢཎᅉࢆゎ᫂ࡋࠊண㜵ἲࠊ἞⒪ἲࡢ zࡇ࡝ࡶࡢ⬻⑌ᝈ࡟࠾ࡅࡿ⬻⅖࣭⬻⑕࡞࡝ࡢ'HYHORSPHQWDO1HXURLPPXQRORJ\3URMHFWⓎ⑕ᶵᗎࢆゎ᫂ࡋ㸪᪂ࡓ࡞ண㜵ἲࠊ἞⒪ἲ
㛤Ⓨࢆࡵࡊࡍࠋ
ࡢ㛤Ⓨࢆࡵࡊࡍࠋ
͞ʹ΍͹೶Ͷ͕͜Ζ‫ڧ؂‬ң࣍‫ߑؽ‬͹մ໎εψϕηՆા੓͹ҡ৙ͳ࣮‫׳‬ࢃ‫ܙ‬གྷਕ εψϕηՆા੓ϕϫζΥέφ
6\QDSWLF3ODVWLFLW\3URMHFWਈ‫ࡋܨ‬๖͹෾Կʀਫ਼ଚͳͨ͹্֒͹෾ࢢ‫ؽ‬ߑԮ‫ރ‬੘ਫ਼

ਈ‫ࡋܨ‬๖෾ԿϕϫζΥέφ
1HXUDO'HYHORSPHQW3URMHFWਈ‫ܨ‬յ࿑͹‫ܙ‬੔ͳͨ͹൅ୣҡ৙͹ϟΩωθ

઴ీ৶໎


Ϟ

ʤʛ ೧ౕʥ‫ࢃ؛‬એव ਈ‫ܨ‬յ࿑‫ܙ‬੔ϕϫζΥέφʤ ೧ౕʛʥ1HXUDO1HWZRUN3URMHFWৼ͹݊߃Ͱ͚Ε͹ͪΌ͹༩๹ʀ࣑ྏʀϨύ
ϑϨ๑


੤ీ५ࢦ

ৼ͹݊߃ϕϫζΥέφ
0HQWDO+HDOWK3URPRWLRQ3URMHFW౹߻ࣨ௒঳͹‫ݬ‬Ҿ‫ڂ‬໎ͳ༩๹ʀ࣑ྏ๑͹֋൅৿Ҭ ੥

౹߻ࣨ௒঳ϕϫζΥέφ
6FKL]RSKUHQLD5HVHDUFK3URMHFWࢩࢼࣉࢫࡣ⚄⤒⣽⬊ྠኈࡢ᝟ሗఏ㐩㒊࡛࠶ࡾࠊእ࠿ࡽࡢ
ࢫࢺࣞࢫ࡟㐺ᛂࡋ࡚ኚ໬ࡍࡿᛶ㉁㸦ࢩࢼࣉࢫྍረᛶ㸧ࢆಖzࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼࡿ㞴἞ᛶ࡚ࢇ࠿
ࡕ࡞ࡀࡽᶵ⬟ࡋ࡚࠸ࡿࠋከࡃࡢ⢭⚄࣭⚄⤒⑌ᝈ࡟࠾࠸࡚ࡣ
ࢇࠊ▱ⓗ㞀ᐖ➼ࡢⓎ⑕ᶵᵓゎ᫂࡜἞⒪ἲ㛤ࢩࢼࣉࢫࡢ␗ᖖࡀᣦ᦬ࡉࢀ࡚࠸ࡿࡀࠊࡑࡢ඲ㇺࡣ᫂ࡽ࠿࡛
Ⓨࢆࡵࡊࡍࠋ
ࡣ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼ
zࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡟ࡼࡿ⮬㛢⑕ࡢⓎ⑕ࡗ࡚⏕ࡌࡿ㞴἞ᛶ࡚ࢇ࠿ࢇࡸ▱ⓗ㞀ᐖࠊ⮬㛢⑕࡞࡝ࡢ⑌ᝈ
ᶵᵓゎ᫂࡜἞⒪ἲ㛤Ⓨࢆࡵࡊࡍࠋ
ࣔࢹࣝື≀ࢆస〇ࡋࠊࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿ
ࡇ࡜࡟ࡼࡾࠊ᪂ࡋ࠸ண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ
⚄⤒⣽⬊࡟ᡂ㛗ࡍࡿ๓ࡢ⚄⤒๓㥑⣽⬊࡜ࠊࡑࢀࡽ࠿ࡽ⏕ࡲࢀࡓ⚄⤒⣽⬊ࡀᡂ⇍ࡋ࡚⏕ࡁᘏࡧ࡚ࡺࡃ㐣⛬㸦ศ໬࣭⏕z⚄⤒⣽⬊ࡢศ໬࣭⏕Ꮡࢆࡘ࠿ࡉ࡝ࡿศᏊ࣓
Ꮡ㸧ࢆไᚚࡍࡿᅉᏊ࡟ࡣࠊ⢭⚄Ⓨ㐩㐜⁫ࠊຍ㱋ᛶ⬻㞀ᐖࡸ࢝ࢽࢬ࣒➼ࢆ◊✲ࡋࠊ᪂ࡓ࡞⬻ࡢⓎ㐩ࡸᶵ⬻⭘⒆ࡢⓎ⏕࡟㛵୚ࡍࡿࡶࡢࡀ࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛
⬟⥔ᣢࡢᶵᵓࢆゎ᫂ࡍࡿࠋࡣࠊ⚄⤒⣽⬊ࡢศ໬࣭⏕Ꮡࢆࡘ࠿ࡉ࡝ࡿศᏊ࣓࢝ࢽࢬ࣒ࡸzୖグࡢᶵᵓࡢ◚ࡓࢇ࡟ࡼࡿ㞴἞ᛶ⬻⚄⤒⑌⎔ቃᅉᏊࡢᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋࠊ⬻ࡢⓎ㐩ࡸᶵ⬟⥔ᣢࡢᶵᵓᝈࡢண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ
ࢆゎ᫂ࡋࠊࡑࢀࡽࡢ㞀ᐖ࡟ࡼࡿ㞴἞ᛶࡢ⬻⚄⤒⑌ᝈࢆඞ᭹
ࡍࡿ἞⒪ἲࠊண㜵ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ
Ⓨ㐩㐣⛬࡟࠾ࡅࡿ⬻ࡢ୰࡛᪂ࡓ࡟ㄌ⏕ࡋࡓ⚄⤒⣽⬊ࡣࠊ⬻ෆࢆ⛣ືࡋ࡞ࡀࡽ⚄⤒✺㉳ࢆ㐺ษ࡟ఙ㛗ࡋ࡚⚄⤒ᅇ㊰ࢆ z⚄⤒⣽⬊ࡢⓎ㐩ᮇ࡟࠾ࡅࡿ⛣ືࠊ⚄⤒✺㉳ᙧᡂࡍࡿࠋࡇࢀࡽࡢ⚄⤒ᅇ㊰ᙧᡂ࡟␗ᖖࡀ⏕ࡌࡿ࡜ࠊ⬻ᙧ ᙧᡂ࡞࡝࡟ࡼࡿ⚄⤒ᅇ㊰ᙧᡂࡢศᏊ࣓࢝ࢽ
ࢬ࣒ࢆゎ᫂ࡍࡿࠋ
ᡂ␗ᖖ࡞࡝ᵝࠎ࡞⚄⤒⑌ᝈࡢཎᅉ࡟࡞ࡿ࡜⪃࠼ࡽࢀ࡚࠸
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⚄⤒ᅇ㊰ᙧᡂࢆไᚚࡍࡿ⣽⬊እ z⚄⤒ᅇ㊰ᙧᡂ␗ᖖ࡟ࡼࡗ࡚⏕ࡌࡿ⢭⚄࣭⚄ࡢ⎔ቃᅉᏊࡢᶵ⬟࡟㛵ࡍࡿศᏊᶵᵓࡸࠊ⯆ዧᛶ࡜ᢚไᛶࡢ ⤒⑌ᝈࡢ⑓ᅉゎ᫂࡜἞⒪ἲࡢ㛤Ⓨ࡟ᐤ୚ࡍ⚄⤒⣽⬊ࡢ⛣ື࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡾࠊ⢭⚄࣭ ࡿࠋ⚄⤒⑌ᝈࡢ᪂ࡋ࠸ண㜵ἲࠊ἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ
⌧௦ࢫࢺࣞࢫ♫఍ࡢ⦰ᅗ࡜࠸࠼ࡿ኱㒔ᕷ࡛ࡣࠊᚰࡢ೺ᗣ zᛮ᫓ᮇࡢ࣓ࣥࢱࣝ࣊ࣝࢫၥ㢟ࡢண㜵せᅉࡸࢆ⼃ࡴࡉࡲࡊࡲ࡞せᅉࡀ⁄ࢀࡿ୍᪉ࠊಶேࢆᨭ࠼ࡿேࠎࡢ ࢙࢘ࣝࣅ࣮࢖ࣥࢢቑ㐍せᅉࢆ᫂ࡽ࠿࡟ࡍ
⤎ࡣⷧࡲࡗ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞୰࡛⮫ᗋ་Ꮫ࣭♫఍་Ꮫⓗ ࡿࠋ᪉ἲㄽ࡟ࡼࡾᚰࡢ೺ᗣ࡙ࡃࡾ◊✲ࡢከ㠃ⓗ࡞᥎㐍ࡀồࡵࡽ zᆅᇦ࡛ᬽࡽࡍㄆ▱⑕ࡢே࡜ᐙ᪘࡬ࡢࢣ࢔ࢆ
ࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊᑡᏊ㧗㱋໬ࡀ㐍ࡴᮾி࡟ ྥୖࡉࡏࡿࠋ
࠾࠸࡚༊࣭ᕷ࡜㐃ᦠࡋࡓ኱つᶍฟ⏕ࢥ࣮࣍ࢺ◊✲ࡢᐇドⓗ z⢭⚄⑌ᝈࡢᛴᛶᮇධ㝔་⒪࡜㏥㝔ᚋእ᮶་ᡂᯝࡸ⮫ᗋ࣭ࢣ࢔⌧ሙ࡜ࡢ༠ാ࡟ࡼࡿࣉࣟࢢ࣒ࣛ㛤Ⓨ➼ࢆ ⒪࡜ࢆ⤖ࡪ⛣⾜ᮇᨭ᥼ࣉࣟࢢ࣒ࣛࢆ㛤Ⓨࡍࡿࠋ
㏻ࡌࠊ኱㒔ᕷࡢᚰࡢ೺ᗣ࡙ࡃࡾ࡟ྲྀࡾ⤌ࡴࠋ⤫ྜኻㄪ⑕ࡣᝈ⪅࡜ᐙ᪘ࡢᬽࡽࡋ࡜೺ᗣ࡟኱ࡁ࡞ᙳ㡪ࢆz⤫ྜኻㄪ⑕ࡢデ᩿἞⒪࡟ᙺ❧ࡘࣂ࢖࣐࣮࢜
ཬࡰࡍᚰࡢ⑓࡛࠶ࡾࠊᝈ⪅ᩘࡣ  ୓ே࡟࠾ࡼࡪࠋ࡯࡜ࢇ
࣮࢝ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
࡝ࡢᝈ⪅ࡣ  ௦࠿ࡽ  ௦࡟Ⓨ⑕ࡋࠊࡑࡢᚋ㛗ᮇ㛫ࡢ἞⒪z㒔❧⑓㝔࡜㐃ᦠࡋ࡚᪩ᮇデ᩿ἲࡢ㛤Ⓨࢆࡵࢆవ൤࡞ࡃࡉࢀࡿࡀࠊ᰿ᮏⓗ࡞ཎᅉࡣ࠸ࡲࡔ୙࡛᫂ᑐ⑕⒪ࡊࡍࠋἲⓗ἞⒪ࡀ⾜ࢃࢀ࡚࠸ࡿࡢࡀ⌧≧࡛࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺz⤫ྜኻㄪ⑕ࡢཎᅉࢆゎ᫂ࡋ᪂ࡓ࡞ண㜵࣭἞࡛ࡣࠊ⚄⤒⛉Ꮫⓗᡭἲ࡟ࡼࡾ⤫ྜኻㄪ⑕ࡢཎᅉ✲᫂ࢆ㐍⒪ἲࢆ㛤Ⓨࡍࡿࠋ
ࡵࠊࡼࡾ᭷ຠ࡞ண㜵࣭἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ

࠺ࡘ⑓࡞࡝Ẽศ㞀ᐖࡣ㏆ᖺᝈ⪅ᩘࡀቑຍࡋ࡚࠾ࡾࠊ⮬ẅz࠺ࡘ⑓ື≀ࣔࢹࣝࢆ☜❧ࡍࡿ࡜࡜ࡶ࡟ࠊ࢜
͑ͯබ͹‫ݬ‬Ҿ‫ڂ‬໎ͳਏஇʀ࣑ྏ๑͹֋൅ ࡢ୺せཎᅉ࡜࡞ࡿ࡞࡝ࠊࡑࡢ♫఍㈇ᢸࡣ㔜࠸ࠋ⑓ែࡀᮍࡔ
ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࡞࡝⬻⣽⬊࡛ࣞ࣋ࣝࡢ
୙࡛᫂ᐈほⓗデ᩿ἲࡶ࡞ࡃࠊ἞⒪ἲࡶ༑ศ࡛ࡣ࡞࠸ࠋᮏࣉ
ゎᯒࢆ㐍ࡵࠊẼศ㞀ᐖࡢ⑓ែゎ᫂ࢆ⾜࡞ࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻ࡢ␗ᖖ㒊఩ࡢྠᐃ࠾ࡼࡧࡑࢀ࡟ᇶ࡙ࡃ
࠺ࠋ㒖ྜྷٝ޻ ͑ͯබϕϫζΥέφᐈほⓗデ᩿ἲࡢ㛤Ⓨࢆ⾜࠺࡜࡜ࡶ࡟ࠊ࠺ࡘ⑓ື≀ࣔࢹࣝ⣔zᇶ♏࡜⮫ᗋࢆᶫΏࡋ◊✲ࢆ୰ᚰ࡟⾜࠸ࠊ⏬
ࡸ⚄⤒̾ࢢࣜ࢔┦㛵ࠊ≉࡟࢜ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ࡞࡝⬻⣽ീࡸ⾑୰ࣂ࢖࣐࣮࣮࢜࢝࡞࡝ᐈほⓗデ᩿ἲ⬊ࣞ࣋ࣝࡢࣔࢹࣝ⣔ࡢゎᯒࢆ㏻ࡋ࡚ࡼࡾ๪స⏝ࡢᑡ࡞࠸἞
$IIHFWLYH'LVRUGHUV3URMHFW࠾ࡼࡧ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ

－ 6 －

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ࣉࣟࢪ࢙ࢡࢺ
࣮ࣜࢲ࣮ࣉࣟࢪ࢙ࢡࢺྡ㸭␎⛠㸭ⱥㄒྡਯເְ੩੏‫ޜ‬͹մ໎ͳਯເ্֒͹࣑ྏ๑֋൅ຌଡ ਇ

ਯເϕϫζΥέφ
6OHHS'LVRUGHUV3URMHFW

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ൕௌ༺೯

‫ߑؽ‬͹մ໎

ʛ ೧  ݆ ঘ໼໽ࢢ ΩϩϏ΢ϱϕϫζΥέφ
ʤ ೧  ݆ʛʥ&DOSDLQ3URMHFWϤϑΫοϱεητϞ͹ҡ৙ͳ࣮‫׳‬


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⌧௦♫఍࡛ࡣኪᆺ໬࡜▷᫬㛫╧╀໬ࡀ㐍⾜ࡋࠊປാࡢ㉁ⓗኚ໬ࡶ࠶ࡗ࡚៏ᛶⓗ࡞╧╀㞀ᐖࢆッ࠼ࡿேࡀቑ࠼࡚࠸ z㐣╀ࢆ࿊ࡍࡿ╧╀㞀ᐖࡢ⑓ែࢆゎ᫂ࡋࠊデࡿࠋ╧╀㞀ᐖࡢ᭱኱ࡢၥ㢟ࡣ╀Ẽ࡟క࠺᪥ᖖ⏕άୖࡢᨭ㞀 ᩿࣭ண㜵࣭἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ࡛࠶ࡿࠋࡲࡓ୰㏵ぬ㓰ࡣຍ㱋➼࡟కࡗ࡚ከࡃࡳࡽࢀࡿࡀ᭷ z╧╀⥔ᣢᏳᐃ໬స⏝ࢆᣢࡘ≀㉁ࡢዌຌᇶ┙ຠ࡞἞⒪ἲࡀ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ㐣╀⑕≧ࡸ╧╀ ࢆゎ᫂ࡋࠊ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋศ᩿໬⑕≧ࢆ࿊ࡍࡿ╧╀㞀ᐖࡢ⑓ែࢆゎ᫂ࡋࠊ᪩ᮇデ᩿࣭ zぬ㓰ไᚚࡢᇶ┙ࢆ⣽⬊࣭ື≀ࣔࢹ࡛ࣝㄪ
἞⒪ຠᯝุᐃ࡟౑࠺ࣂ࢖࣐࣮࣮࢜࢝ࡸ᪂つ἞⒪⸆ࡢ㛤Ⓨࢆ ࡭ࠊ೺ᗣⓗ࡞╧╀ࡢ᮲௳ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ࡵࡊࡍࠋ౫Ꮡᛶ⸆≀ࡣࠊ῝้࡞♫఍ၥ㢟࡛࠶ࡿ⸆≀౫Ꮡࡸᗁぬ࣭ғଚ੓༂෼͹ࡠ༽‫ؽ‬঄մ໎ͳͨ͹ҫྏԢ༽ዶ᝿ࡢཎᅉ࡛࠶ࡿ୍᪉ࠊ⑊③ࡸⓎ㐩㞀ᐖ࡞࡝ࡢ἞⒪⸆࡜ࡋ z౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎ࡟ᇶ࡙ࡃ౫Ꮡ⑕࡞࡝
࡚ᗈࡃ⏝࠸ࡽࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ౫Ꮡᛶ⸆≀ ࡢ἞⒪ἲ࠾ࡼࡧண㜵ἲࢆ㛤Ⓨࡍࡿࠋࡢస⏝ᶵᗎࢆゎ᫂ࡋࠊࡑࡢᡂᯝࢆ་⒪ᛂ⏝ࡍࡿࡓࡵࡢ◊✲ zಶࠎேࡢ㑇ఏᏊ࡟ྜࡗࡓ᪩ᮇ࠿ࡽࡢ㐺ษ࡞ஓీ࿪ཾ ғଚ੓༂෼ϕϫζΥέφࢆ㐍ࡵࡿࡇ࡜࡛ࠊ౫Ꮡ⑕࡞࡝ࡢ᪂ࡓ࡞἞⒪ἲࡸண㜵ἲࢆ㛤 ⑊③἞⒪ἲࡢᨵⰋ࡜㐺ᛂᣑ኱ࢆࡵࡊࡍࠋ
Ⓨࡋࠊࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ἲ࡞࡝ࡢ⑊③⟶⌮ᢏ⾡ࡢྥ z$'+'ࠊ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ࡞࡝ࡢⓎୖࡸࠊὀពḞዴከືᛶ㞀ᐖ㸦$'+' ࡸ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ 㐩㞀ᐖࡢ᪂つ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ$GGLFWLYH6XEVWDQFH3URMHFW㞀ᐖ࡞࡝ࡢⓎ㐩㞀ᐖࡢ᪂つ἞⒪ἲࢆ㛤ⓎࡍࡿࠋΩϩϏ΢ϱ‫ؽ‬೵෈સͶΓΖ࣮‫׳‬͹൅঳෾ࢢ

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নీ‫ݓ‬೯ ϤϑΫοϱϕϫζΥέφ
8ELTXLWLQ3URMHFW࢝ࣝࣃ࢖ࣥࡣࠊᵝࠎ࡞⣽⬊ෆ⺮ⓑ㉁ࢆษ᩿ࡋ࡚ᶵ⬟ࡸᵓ㐀ࢆኚ᥮ࡍࡿࡇ࡜࡟ࡼࡾࠊ⣽⬊ࢆࠊࡦ࠸࡚ࡣ⏕యࢆㄪ⠇ࡋ z࢝ࣝࣃ࢖ࣥࡢస⏝ᶵᗎࢆศᏊ࡛ࣞ࣋ࣝゎᯒ࡚࠸ࡿ㓝⣲࡛࠶ࡿࠋࡑࡢࡓࡵࠊ࢝ࣝࣃ࢖ࣥࡀ࠺ࡲࡃാ࠿࡞ ࡋࠊࡑࡢ⏕⌮ᶵ⬟ࢆ᫂☜࡟ࡍࡿࠋࡃ࡞ࡿ࡜➽ࢪࢫࢺࣟࣇ࢕࣮ࡸ⫶ฟ⾑࡞࡝ࠊᵝࠎ࡞⑌ᝈࡀⓎ z࢝ࣝࣃ࢖ࣥ࡞࡝ࡢ㑇ఏᏊᨵኚ࣐࢘ࢫࢆ⑌ᝈ
⑕ࡍࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ࢝ࣝࣃ࢖ࣥࡀ࡝ࡢࡼ࠺࡟⣽ ࣔࢹࣝ࡜ࡋ࡚ࠊⓎ⑕ᶵᵓࢆゎᯒࡍࡿࠋ⬊ࡢാࡁࢆㄪ⠇ࡋ࡚࠸ࡿࡢ࠿ࠊศᏊࡢ࡛ࣞ࣋ࣝゎᯒࡋࠊࡇ z࢝ࣝࣃ࢖ࣥ୙඲⑌ᝈ࡛ࡢ㛵㐃ศᏊࡢኚ໬ࢆ
ࢀࡽࡢ⑌ᝈࡀⓎ⑕ࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡛ࠊ⑌ᝈ ゎᯒࡋࠊࡑࡢデ᩿࣭἞⒪ࡢ᪉ྥᛶࢆ♧ࡍࠋࡢデ᩿ࡸ἞⒪ࡢ᪉ྥᛶࢆ♧ࡍࠋࣘࣅ࢟ࢳࣥࡣ⣽⬊ෆ࡟࠾࠸࡚ࠊࡉࡲࡊࡲ࡞⺮ⓑ㉁ࡸ⣽⬊ zࣘࣅ࢟ࢳࣥ࡟╔┠ࡋ࡞ࡀࡽࠊࣃ࣮࢟ࣥࢯࣥ
ᑠჾᐁࡢ⏕Ṛࢆྖࡾࠊࡑࢀࡽࡢ㐠࿨ࢆỴᐃ௜ࡅࡿᅉᏊ࡛࠶ ⑓࡞࡝ࡢ⚄⤒ኚᛶ⑌ᝈࡢⓎ⑕ᶵᵓ࡟㏕ࡿࠋ
ࡿࠋ㏆ᖺࠊࣘࣅ࢟ࢳࣥࡢ␗ᖖࡣࠊࣃ࣮࢟ࣥࢯࣥ⑓ࢆࡣࡌࡵ z⏕యෆࡢࣘࣅ࢟ࢳࣥ⎔ቃࢆᨵኚࡋ࡚ࠊ⑓Ẽࡢࣔࢹࣝື≀ࢆస〇ࡍࡿࠋ࡜ࡍࡿᵝࠎ࡞⑌ᝈ࡜ᐦ᥋࡟㛵ಀࡍࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸
ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊㅦ࡟ໟࡲࢀࡓࣘࣅ࢟ࢳࣥࡢ⏕య z⏕యෆ࡛ᵝࠎ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࣘࣅ࢟ࢳ
ෆ࡟࠾ࡅࡿᙺ๭ࢆゎ᫂ࡍࡿ࡜࡜ࡶ࡟ࠊࣃ࣮࢟ࣥࢯࣥ⑓࡞࡝ ࣥࡢᶵ⬟ࢆ᫂ࡽ࠿࡟ࡋ࡚ࠊࣄࢺࡢ೺ᗣ⥔ᣢ࡟ᙺ❧࡚ࡿࠋ
ࡢ⚄⤒ኚᛶ⑌ᝈ࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

㐀⾑ᖿ⣽⬊ࡣࠊ⮚ჾ࡟⾑ࢆ㏦ࡾฟࡋࠊࡀࢇࡸឤᰁ⑕࡜ᡓ
‫ࡋײ‬๖Νཤ༽݄ͪ͢ӹ࠸ਫ਼ҫྏٗढ़ͳ͗Ξ ࠺ච␿⣽⬊ࢆ⏘ࡳฟࡋ࡚ࡃࢀࡿࠊ⏕య࡟࡜ࡗ࡚ᚲ㡲࡞⣽⬊ zL36 ⣽⬊ࡢヨ㦂⟶ෆᇵ㣴࡟ࡼࡗ࡚ࠊ㐀⾑ᖿ࣑ྏ๑͹֋൅
‫޻ ݬ‬ඛ‫ࡋײ‬๖ϕϫζΥέφ
6WHP&HOO3URMHFW

L36 ࡋ๖͹ΰόϞฦॄͶΓΖ࣮‫׳‬͹࣑ྏ๑͹֋൅ ‫ٸ‬Ԯ༐Ҳ࿢࠸ਫ਼ҫྏϕϫζΥέφ
5HJHQHUDWLYH0HGLFLQH3URMHFW

L36 ⣽⬊࡟ࡣᵝࠎ࡞་⒪ᛂ⏝ࡀᮇᚅࡉࢀࠊ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࡀࠊࡑࡢࢤࣀ࣒ࢆ᧯సࡍࡿࡇ࡜ࡢᅔ㞴ࡉࡀ㧗࠸㞀 z೺ᗣ࡞ே⏤᮶ࡢ L36 ⣽⬊࡟⑌ᝈࡢཎᅉ࡜࡞
ቨ࡜࡞ࡗ࡚ࡁࡓࠋࡋ࠿ࡋࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓎᒎ࡟ࡼࡾࠊ ࡿኚ␗ࢆᑟධࡍࡿࡇ࡜࡛ࠊ⑌ᝈࢆ෌⌧ࡋࡑ
ࡢⓎ⑕ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
ࡑࡢ㞀ቨࡶྲྀࡾᡶࢃࢀࡘࡘ࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ
L36 ⣽⬊࡜ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊ㑇ఏᛶ zᝈ⪅⏤᮶ࡢ L36 ⣽⬊ࡢኚ␗ࢆṇᖖ࡞ '1$ 㓄⑌ᝈࣔࢹࣝస〇࡟ࡼࡿ⑌ᝈࡢⓎ⑕ᶵᗎࡢゎᯒࠊ࠾ࡼࡧ⑌ᝈ ิ࡟ಟṇࡋࠊ⣽⬊ࡢᶵ⬟ࢆᅇ᚟ࡉࡏ࡚⛣᳜ࡢཎᅉ࡜࡞ࡿኚ␗ࢆಟṇࡋࡓ L36 ⣽⬊࡟ࡼࡿ⣽⬊⛣᳜἞⒪ ἞⒪ࢆ⾜࠺ࡓࡵࡢᢏ⾡ࢆ㛤Ⓨࡍࡿࠋἲࡢ㛤Ⓨࢆࡵࡊࡍࠋz⬻༞୰ࢆ㉳ࡇࡋࡓ⬻ෆ࡛సࡽࢀࡿࢱࣥࣃࢡ
㉁ࡸ⬡㉁ࠊపศᏊ໬ྜ≀࡟╔┠ࡋ࡚ࡑࢀࡽ
᪥ᮏࡣ㧗㱋໬♫఍ࢆ㏄࠼ࠊ⬻༞୰ࡢᝈ⪅ᩘࡀቑຍࡋ࡚࠸
ࡢᶵ⬟ࡸ⏕⌮ⓗព⩏ࢆゎ᫂ࡋࠊ᪂ࡋ࠸⬻༞೶ଖ஦Ͷ͕͜ΖԎ঳ͳर෰ϟΩωθϞ͹մ ࡿࠋ⬻༞୰ᚋࡢ㯞⑷ࡸ⬻ᶵ⬟ࡢ㞀ᐖࡣࠊᝈ⪅ࡢ♫఍᚟ᖐ࡟ ୰ࡢ἞⒪ἲࢆ㛤Ⓨࡍࡿࠋ኱ࡁ࡞ᨭ㞀࡜࡞ࡗ࡚࠸ࡿࡀࠊ⬻༞୰࡟ᑐࡍࡿ᭷ຠ࡞἞⒪ἲ
z⬻᱾ሰࡸㄆ▱⑕࡛ࡣ⬻ෆ࡟⅖⑕ࡀ㉳ࡇࡿ໎ࡣࡲࡔ༑ศ࡟㛤Ⓨࡉࢀ࡚࠸࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⬻ࡀࠊ⅖⑕ࢆ㉳ࡇࡍཎᅉ≀㉁ࢆ⬻ෆ࠿ࡽ᤼㝖༞୰ᝈ⪅ࡢ♫఍᚟ᖐࢆಁࡍࡼ࠺࡞᪂ࡋ࠸἞⒪ἲࢆ㛤Ⓨࡍࡿࡍࡿ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋࠊࡇࢀࢆ᪂ࡋ࠸἞ࣥీ ਺
ࡓࡵ࡟ࠊᦆയࡋࡓ⬻ࡀ࡝ࡢࡼ࠺࡟ᅇ᚟ࡍࡿ࠿ࢆヲ⣽࡟ゎ᫂೶ଖ஦ϩϋγϱηϕϫζΥέφ⒪ἲࡢ㛤Ⓨ࡟ᛂ⏝ࡍࡿࠋࡍࡿࠋ᭱㏆࡟࡞ࡗ࡚ච␿Ꮫࡸ⚄⤒⛉Ꮫࡢ᪂ࡋ࠸◊✲ᡭἲࡀz⬻༞୰ࢆ㉳ࡇࡋࡓᚋࡢ⬻ෆ࡛ࡣࠊቯࢀࡓ⚄ὀ┠ࢆᾎࡧ࡚࠾ࡾࠊࡇࢀࡽࢆᛂ⏝ࡍࡿࡇ࡜࡟ࡼࡗ࡚⬻༞୰⤒ࢿࢵࢺ࣮࣡ࢡࡀ෌ᙧᡂࡉࢀࡿࡀࠊࡇࡢ࣓
6WURNH5HQDLVVDQFH3URMHFW◊✲ࢆ᪂ࡋ࠸ゅᗘ࠿ࡽⓎᒎࡉࡏࠊ⬻༞୰ᚋࡢ⬻ࡢ෌⏕ࠊᝈ࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡗ࡚ࠊ⬻༞୰⪅ࡢ♫఍࡬ࡢ᚟άࢆ୺┠ᶆ࡜ࡋ࡚◊✲ࢆ⾜࠺ࠋᝈ⪅ࡢᶵ⬟ணᚋࢆᨵၿࡍࡿ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡿࠋӣಊ্֒͹බସմ໎ͳਈ‫ྏ࣑׳࣮ܨ‬ψϑΰʖνʖ͹֋൅

࡛࠶ࡿࠋ㧗㱋໬♫఍ࢆ㏄࠼ࡓࢃࡀᅜ࡛ࡣࠊ㦵㧊⛣᳜ࡸ㍺⾑ ⣽⬊࣭⾑ᑠᯈ࣭ච␿⣽⬊ࢆຠ⋡ⓗ࡟సࡾฟࡢࢯ࣮ࢫࢆ☜ಖࡍࡿ᪂ࡋ࠸་⒪ᢏ⾡ࡢ㛤Ⓨࡀồࡵࡽࢀ࡚࠸ ࡍ᪉ἲࢆ㛤Ⓨࡍࡿࠋࡿࠋࡲࡓࠊࡀࢇ⣽⬊ࡢቑṪ࡜㌿⛣࡟ࡣࠊ㐀⾑ᖿ⣽⬊࡜ඹ㏻ zᛴᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚ࠼ࡿࠊ
ࡢศᏊࡀ౑ࢃࢀ࡚࠸ࡿࡇ࡜ࡀุ᫂ࡋࡓࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ ᪂ࡋ࠸ࡀࢇ἞⒪⸆ࡢ㛤Ⓨࢆࡵࡊࡍࠋ
ࡣࠊL36 ⣽⬊࠿ࡽ㐀⾑ᖿ⣽⬊࣭⾑ᑠᯈ࣭ච␿⣽⬊ࢆຠ⋡ⓗ zࡀࢇࡢ㌿⛣࡟౑ࢃࢀࡿศᏊࢆᶆⓗ࡜ࡋࡓࠊ࡟సࡾฟࡍ᪉ἲࠊࡑࡋ࡚ᖿ⣽⬊㑇ఏᏊࢆᶆⓗ࡜ࡋࡓ᪂ࡋ࠸ ᪂ࡋ࠸ᢠࡀࢇ๣ࡢ㛤Ⓨࢆࡵࡊࡍࠋ
ࡀࢇ἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ᝝ ৽࣑

ӣಊ্֒ϕϫζΥέφ
0RWRU'LVRUGHUV3URMHFW⬻༞୰࣭ࣃ࣮࢟ࣥࢯࣥ⑓࣭⬨㧊ᑠ⬻ኚᛶ⑕࡞࡝࡛ࡣࠊ኱⬻⓶㉁ࠊᇶᗏ᰾ࠊᑠ⬻ࡀ」ྜⓗ࡟㞀ᐖࡉࢀࡿࡓࡵࠊࡑࡢ⑓ z኱⬻࣭ᇶᗏ᰾࣭ᑠ⬻ࡢ㐠ືไᚚ࡟࠾ࡅࡿᶵ
ែࡣ」㞧࠿ࡘከᵝ࡛࠶ࡿࠋࡑࡢ⤖ᯝࠊ⑓ែࡢᮏ㉁ࡀ୙㏱᫂ ⬟㐃ᦠࢆゎ᫂ࡍࡿࠋ࡛࠶ࡾࠊ἞⒪ࡢ⌧≧ࡣᑐ⑕ⓗ࡟␃ࡲࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ zከᵝ࡞㐠ື㞀ᐖࡢ⑓ែࢆศᯒ࣭ྍど໬ࡍࡿࡣࠊ ࡘࡢ㐠ື୰ᯡࡢసືཎ⌮ࢆゎ᫂ࡋࠊࡑࡢᡂᯝࢆ㋃ࡲ ࢔ࣝࢦࣜࢬ࣒ࢆ㛤Ⓨࡍࡿࠋ࠼࡚ࠊ⚄⤒⑌ᝈ࡟࠾ࡅࡿ」㞧࡞⑓ែࢆᐈほⓗ࡞ࣃ࣓࣮ࣛࢱ z⚄⤒⑌ᝈࡢ἞⒪ࢆ࢞࢖ࢻࡍࡿ⚄⤒⑌ᝈ἞⒪࡟ኚ᥮ࡋࠊ἞⒪࡟ࣇ࢕࣮ࢻࣂࢵࢡࡍࡿࢩࢫࢸ࣒ࢆ㛤Ⓨࡍࡿ ࢼࣅࢤ࣮ࢱ࣮ࡢᐇ⏝໬ࢆࡵࡊࡍࠋ
࡞࡝ࠊ」ྜⓗ◊✲ࢆ᥎㐍ࡍࡿࠋ

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ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮ ᪥ᮏ࡟࠾ࡅࡿどぬ㞀ᐖ⪅ࡣ  ୓ேࢆ㉸࠼ࠊ♫఍ᦆኻ㢠໤ຜʀࢻਈ‫ܨ‬ร੓࣮‫׳‬͹බସմ໎ͳ࣑ྏ๑ࡣ  ඙෇௨ୖ࡜ヨ⟬ࡉࢀ࡚࠸ࡿࠋ≉࡟Ḣ⡿ᆺࣛ࢖ࣇࢫࢱ࢖
ࣝࡢᾐ㏱ࡸ㧗㱋໬♫఍ࢆ⫼ᬒ࡟ࠊࠕ║ࡢᡂே⑓ࠖ࡜ࡶ࠸࠼ z⑌ᝈࣔࢹࣝື≀ࢆ⏝࠸࡚ࠊ⥙⭷ࡢ⚄⤒ಖㆤࡿ⥳ෆ㞀ࡸ⢾ᒀ⑓⥙⭷⑕࡞࡝ࡢᝈ⪅ᩘቑຍࡀ኱ࡁ࡞ㄢ㢟࡜ ⒪ἲࢆ㛤Ⓨࡍࡿࠋ‫ְࢻ ߀߶ీݬ‬බସϕϫζΥέφ࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ㧗㱋໬ࢆ㏄࠼ቑຍࡍࡿ zど⚄⤒⅖ࡢⓎ⑕࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࠋ
どぬ㞀☀⪅ࡢ⏕άࡢ㉁㸦42/㸧ྥୖࢆᅗࡿࡓࡵ࡟ࠊ㞴἞ᛶ zど⚄⤒෌⏕ࢆಁ㐍ࡍࡿᡭἲࢆ☜❧ࡍࡿࠋ║⑌ᝈࣔࢹࣝࡢ㛤Ⓨࢆ㏻ࡋ࡚ࠊヲ⣽࡞Ⓨ⑕࣓࢝ࢽࢬ࣒ࡢゎ
9LVXDO5HVHDUFK3URMHFW᫂࡜᪂ࡓ࡞἞⒪ἲࡢ㛤Ⓨࢆࡵࡊࡍࠋ

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ࡋࠊᚲせ࡞᫬࡟฼⏝࡛ࡁࡿࡓࡵࡢᨭ᥼యไ
㸦➽ⴎ⦰ᛶഃ⣴◳໬⑕㸧⒪㣴⪅ࡣࠊ࿧྾ⱞࡸ㣗≀ࡀ࿐ࡳ㎸ࡢᵓ⠏ࢆࡵࡊࡍࠋ
ྏ཈ࢩԋεητϞ͹֋൅ʀ඲Ճ
ࡵ࡞࠸ࠊពᛮ␯㏻ࡀᅗࢀ࡞࠸࡞࡝ࡢேࡢᑛཝ࡟࠿࠿ࢃࡿⱞ
z$/6 ࡸ᭱㔜ᗘࡢ㞀ᐖࢆᣢࡘᝈ⪅࡬ࡢ⏕࿨ࡢࡋࡳࢆᢪ࠼࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊࡇ࠺ࡋࡓ≧ែࡢ⥔ᣢ࣭ᑛཝ࡟ࡘ࡞ࡀࡿ┳ㆤࢣ࢔ࢆྥୖࡉࡏ
஦ࢃ༑‫ل‬⦆࿴ἲࡸఫࡳ័ࢀࡓᆅᇦ࡛Ᏻ඲࣭Ᏻᚰ࡞⒪㣴⏕άࢆ㏦ࡿࡇೋබίΠ؅‫ޤ‬ϕϫζΥέφࡿࠋ࡜ࡀ࡛ࡁࡿࡓࡵࡢᨭ᥼ࢩࢫࢸ࣒࡞࡝ࢆ㛤Ⓨࡋࠊ㉸㧗㱋♫఍zᅾᏯ་⒪Ᏻ඲ࡸ㞴⑓ಖ೺άືࡢ᥎㐍࡟ࡼ
ࢆ㏄࠼ࡿࢃࡀᅜ࡟࠾ࡅࡿᅾᏯ⒪㣴ᨭ᥼ࣔࢹࣝࢆᥦ♧ࡍࡿࡇࡾࠊᏳ඲࡞⒪㣴⎔ቃ࣭ᨭ᥼ࢩࢫࢸ࣒ࡢ඘ᐇ
$/61XUVLQJ&DUH3URMHFW࡜࡟ࡘ࡞ࡆࠊ42/ ࡢྥୖ࡬ᐤ୚ࡍࡿࠋ
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௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ศ⿣㓝ẕRif1ࡢᵓ㐀࣭ᶵ⬟ࡢヲ⣽࡞ゎᯒ࠿ࡽࠊRif1ࡀG4⤖ྜࢆ௓ࡋ࡚ࢡ࣐ࣟ
ࢳ࣮ࣥࣝࣉࢆᙧᡂࡍࡿᵝᘧࡢࣔࢹࣝࢆᥦၐࡋࡓ(Moriyama et al. JBC; Kobayashi
et al. MCB)࣭ Rif1ࡢG4࡟ᑐࡍࡿぶ࿴ᛶࠊࢺ࣏ࣟࢪ࣮≉␗ᛶ࡞࡝ࢆ᫂ࡽ࠿࡟ࡋࡓ(Masai et al.
Scientific Reports)࣭ ஧ ᮏ 㙐 DNA ୖ ࡛ ࡢ ࠊ G4 ᙧ ᡂ ࡟ క ࠺ DNA 㧗 ḟ ᵓ 㐀 ࡢ ኚ ໬ ࢆ ᫂ ࡽ ࠿ ࡟ ࡋ ࡓ(Masai et al. JBC)ࠋ
࣭ G4ᵓ㐀ࡣ1ᮏ㙐࣮ࣝࣉࢆ᭷ࡍࡿࡇ࡜ࢆ฼⏝ࡋ࡚ࠊไ㝈㓝⣲ࢆ⏝࠸࡚⣽⬊ෆG4ࢆ᳨ฟࡍࡿ᪂つᢏἲࢆ㛤Ⓨࡋࡓࠋ࣭ Rif1ࡢCᮎ➃ࡢ㝈ᐃࡉࢀࡓ࢔࣑ࣀ㓟ࡀࠊ᰾⭷࡬ࡢᒁᅾࠊᰁⰍయ㧗ḟᵓ㐀ࡢᙧᡂ࠾ࡼࡧ」〇ࢱ࢖࣑ࣥࢢࡢไᚚ࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭ Rif1ቑ⏘ࡣࠊSᮇ㐍⾜㜼ᐖࢆ♧ࡍ࡜ඹ࡟ࠊMᮇࢆshort spindle࡛arrestࡉࡏࡿࠋ࣭ ኱⭠⳦plasmidࡢ➨஧ࡢ」〇⣔࡟ࡼࡿຠ⋡ࡢࡼ࠸⏕Ꮡ࡟ࡣࠊter㏆ഐࡢ㓄ิࠊG4⤖ྜ⬟ࢆ᭷ࡍࡿYcjDࢱࣥࣃࢡ㉁ࡀせồࡉࢀࡿࠋ࣭ Cdc7ࡣCK1(࢝ࢮ࢖ࣥ࢟ࢼ࣮ࢮ)࡜࡜ࡶ࡟ࠊClaspinࡢ」〇ࢫࢺࣞࢫ౫Ꮡⓗࣜࣥ㓟໬ࢆ௓ࡋ࡚」〇ࢫࢺࣞࢫㄏᑟࢆไᚚࡍࡿࠋ
࣭ Cdc7ࡢάᛶ໬ࢧࣈࣘࢽࢵࢺASKࡢ⬻≉␗ⓗࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡣࠊṌ⾜㞀ᐖࠊ②ᨥ࡞࡝ࡢ⑕≧ࢆ♧ࡋࠊ⏕ᚋ22᪥ࡲ࡛࡟Ṛஸࡍࡿࠋ࣭ Cdc7ࡣAuroraBࢆࣜࣥ㓟໬ࡋࠊάᛶ໬ࡋࠊMᮇึᮇࡢ㐍⾜ཬࡧࢫࣆࣥࢻࣝ㐍⾜ࢳ࢙ࢵࢡ࣏࢖ࣥࢺ࡟㛵୚ࡍࡿࠋ✲       ᡂ

࣭ Rif1-G4」ྜయࡢศᏊᙧែࢆCryo㟁㢧࡟ࡼࡾࡉࡽ࡟ヲ⣽࡟ゎᯒࡍࡿࠋ࣭ ⣽⬊ෆ࡛ࡢG4ᙧᡂ࡟ᙳ㡪ࢆ୚࠼ࡿᅉᏊ(⣽⬊࿘ᮇࠊ࢚ࣆࢤࣀ࣒ࠊ㌿෗ࠊ㗪ᆺࡢ㉸ࡽࡏࢇᵓ㐀࡞࡝)ࢆỴᐃࡍࡿࠋ࣭ Rif1ࡢC➃ࢆ௓ࡋࡓ᰾⭷࡜ࡢ┦஫స⏝ࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ࣭ 㠀ࢥ࣮ࢻ㡿ᇦࡢ㌿෗ࡀ᰾ᵓ㐀/」〇㛤ጞ࡟ཬࡰࡍᙳ㡪ࡢゎ᫂ࠋ
࣭ G4ᵓ㐀ࡢᙧᡂࡀࢾࢡࣞ࢜ࢯ࣮࣒ᵓ㐀ࢆ㝖እࡍࡿᶵᵓࡢゎ᫂ࠋ(3) ᅜෆእࡢ◊✲≧ἣ࣭ Rif1࡜᰾⭷ࡢ┦஫స⏝ࡢDSBಟ᚟ࠊ⤌᥮࠼ࠊ㌿෗࡞࡝࡬ࡢᙳ㡪ࡢゎ᫂ࠋࢤࣀ࣒ᰁⰍయࡢ」〇•⤌᥮࠼•ಟ᚟➼࡟ࡘ࠸࡚ࡣࡑࢀࡒࢀࠊ✀ࠎࡢ⏕≀✀࡛ ࣭ Rif1ࡢཷ⢭༸Ⓨ⏕ࠊศ໬࡟࠾ࡅࡿᶵ⬟ࡢゎ᫂ࠋࡢゎᯒࡀ㐍ࢇ࡛࠸ࡿࠋ」〇㛤ጞࡢ㓝⣲Ꮫⓗ◊✲ࡣฟⱆ㓝ẕࡢ⣔࡛እᅜཬࡧ᪥ ࣭ G4౫ᏑⓗDNA」〇ࢆ⢭〇ࢱࣥࣃࢡ㉁࠿ࡽ෌ᵓ⠏ࡋࠊG4ᵓ㐀࡟౫Ꮡࡋ࡚」〇ᮏ࡛ᛴ㏿࡟㐍⾜ࡋ࡚࠸ࡿࠋᡃࠎࡣ」〇ࣉࣟࢢ࣒ࣛࡢไᚚᅉᏊࡢྠᐃࢆୡ⏺࡟ࡀ㛤ጞࡍࡿࡇ࡜ࢆド᫂ࡍࡿࠋඛ㥑ࡅ࡚⾜ࡗࡓࠋࡇࡢ◊✲࠿ࡽࠊG4ࡀᴟࡵ࡚㔜せ࡞ᙺ๭ࢆᯝࡓࡍ஦ࢆⓎぢࡋ ࣭ Claspinࡢ⾑Ύ㣚㣹࠿ࡽࡢቑṪㄏᑟ࡟࠾ࡅࡿᙺ๭ࢆゎ᫂ࡍࡿࠋࡓࠋཪࠊ⣽⳦࠿ࡽࣄࢺࡲ࡛ಖᏑࡉࢀࡓᬑ㐢ⓗ࡞」〇㛤ጞᶵᵓ࡟G4ࡀ㛵୚ࡍࡿ ࣭ ClaspinࡢศᏊෆ┦஫స⏝࡟ࡼࡿάᛶไᚚࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋྍ⬟ᛶࢆᣦ᦬ࡋࠊG4ࡢ」〇㛤ጞ࡟࠾ࡅࡿᙺ๭ࡢゎ᫂ࢆ┠ᣦࡋ࡚࠸ࡿࠋG4ࡢᶵ ࣭ ື≀⣽⬊Cdc7/ASKࡢⓎ⏕㐣⛬࠾ࡼࡧྛ✀⤌⧊࡟࠾ࡅࡿᶵ⬟ࡢゎ᫂ࠋ⬟࡟ࡘ࠸࡚ࡣ᭱㏆⥆ࠎ࡜᪂ࡋ࠸Ⓨぢࡀࡉࢀ࡚࠾ࡾࠊ௒ᚋ┈ࠎከࡃࡢ▱ぢࡀ㞟 ࣭ Cdc7࠾ࡼࡧASKࡀࠊ⬻ࡢⓎ⏕ࠊᙧᡂࠊᶵ⬟ࢆไᚚࡍࡿ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ✚ࡉࢀࡿ࡛࠶ࢁ࠺ࠋཪG4ᵓ㐀ࢆᶆⓗ࡜ࡋࡓ๰⸆ࡶෆእ࡛㐍⾜ࡋ࡚࠸ࡿࠋࡋ࠿ ࣭ Cdc7Ḟᦆୗ࡛ࡢ⚄⤒Ⓨ⏕ࡸࠊ⾑⌫⣔⣽⬊Ⓨ⏕ࡢ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠋ
ࡋࠊG4ࡢࢤࣀ࣒ᶵ⬟ไᚚ࡟࠾ࡅࡿᙺ๭ࡢ඲యീ࡜ඹ࡟ࠊ⣽⬊ෆ࡛࡝ࡢࡼ࠺࡟ ࣭ Sᮇ࡜Mᮇࡢඹᙺࡢ◚⥢࡟ࡼࡿࠊࡀࢇ⣽⬊Ṛㄏᑟࡢ࣓࢝ࢽࢬ࣒࡜๰⸆࡬ࡢᛂ
Ꮡᅾࡋࠊࡑࡢᙧᡂࡀไᚚࡉࢀࡿ࠿࡜࠸࠺᰿ᮏⓗ࡞ၥ㢟ࡀᮍゎỴ࡛࠶ࡿࠋ⏝ࠋ

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Masai, H. et al. (2019), Scientific Reports, in press; Kobayashi, S. et al. (2019) Mol. Cell. Biol. pii: e0036418.; Masai, H. et al., J. Biol. Chem. 293, 17033; Moriyama et al. (2018) J. Biol. Chem. 293, 3607; Irie et al.
Eur. J. Med. Chem. 130, 406; Moriyama et al. (2017) Adv Exp Med Biol 1042, 287; Masai et al. (2017) Curr.
Genet. 45, 6494; Masai, H. (2017) Cell Cycle 6, 735; You et al. (2017) NAR 45,6495; Matsumoto et al. (2017)
MCB 37. pii: e00355-16; Toteva et al. (2017) PNAS 114, 1093; Yang et al. (2016) Nature Communications
7:12135 (2016); You et al. (2016) Cell Cycle 15, 1213; Tanaka et al. (2016) Biochem. Biophys. Res. Commun.
470, 546; Tanaka et al. (2016) J. Biol. Chem. 291, 6316; Zech et al., (2015) PLoS One 10, e0132595; Iguchi etal. (2015) J. Immunol. 195, 982; Kanoh et al. (2015) Nature Struct. Mol. Biol. 22, 889; Masai et al. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵࣉ ࠗ㠀ᶆ‽ᆺ᰾㓟ᙧែࡢ⏕⌮࣭⑓⌮࡜ࡑࡢไᚚ࠘2018.11.28
㹼11.30; Masai et al. 3R&3C Symposium, November 12㹼16, 2018, Kanazawa, Japan; ṇ஭ஂ㞝 ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࣒࢘ 2018.9.25 ி㒔ᗓ; ⏣୰༟ࡽ ᪥ᮏ㑇ఏᏛ఍࣮࣡ࢡࢩࣙࢵࣉ 2018.9.19㹼
9.21 ዉⰋඛ➃኱Ꮫ ዉⰋ┴; Masai et al. THE 3RD TRANSMED-VN CONFERENCE 2018 University of
Medicine & Pharmacy (UMP), August 19-20, 2018, HCM City – Vietnam; ṇ஭ ஂ㞝 ⏕࿨⛉Ꮫ⣔Ꮫ఍ྜྠᖺḟ኱఍㸦ConBio2017㸧2017 ᖺ 12 ᭶ 6 ᪥; Masai et al. CSH Meeting Cold Spring Harbor Laboratory, New
York, USA, September 5-9, 2017; Cold Spring Harbor Asia conference on DNA Metabolism, Genomic Stabilityand Human DiseaseࠊJune 13-17, 2016ࠊChina; Masai, H. HiHA ➨ 6 ᅇ Workshop Hiroshima ResearchCenter for Healthy Agingࠊ2016 ᖺ 7 ᭶ 8 ᪥ࠊᗈᓥ኱Ꮫ㸦ᗈᓥ㸧;ṇ஭ ஂ㞝 ᪥ᮏ㐍໬Ꮫ఍ ➨ 18 ᅇᮾி኱఍࣮࣡ࢡࢩࣙࢵࣉࠊ2016 ᖺ 8 ᭶ 27 ᪥ࠊᮾிᕤᴗ኱Ꮫ኱ᒸᒣ࢟ࣕࣥࣃࢫ㸦ᮾி㸧;⏣୰ ༟ࠊ㛵 ⏤⨾㤶ࠊṇ஭ ஂ㞝 ➨ 88 ᅇ᪥ᮏ㑇ఏᏛ఍኱఍ ࣮࣡ࢡࢩࣙࢵࣉࠊ2016 ᖺ 9 ᭶ 9 ᪥ࠊ᪥ᮏ኱Ꮫ㸦㟼ᒸ㸧; ṇ஭ ஂ㞝ࡽࠊ ➨ 89 ᅇ ᪥ᮏ⏕໬Ꮫ఍኱఍ࠊ 2016 ᖺ 9 ᭶ 26 ᪥ࠊ௝ྎ㸦ᐑᇛ㸧; ṇ஭ ஂ㞝ࡽࠊ➨ 75 ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ࢩ࣏ࣥࢪ࣒࢘ࠊ2016 ᖺ 10 ᭶ 8 ᪥ࠊᶓ὾㸦⚄ዉᕝ㸧;ṇ஭ ஂ㞝ࡽࠊ➨ 39
ᅇ ᪥ᮏศᏊ ⏕≀Ꮫ ఍ᖺ఍ࢩࣥ ࣏ࢪ ࣒࢘ ࠊ2016 ᖺ 12 ᭶ 2 ᪥ࠊ ᶓ὾(⚄ዉᕝ); Masai et al., 10th 3R
Symposium Nov 13-17, 2017 Organizer; Cold Spring Harbor Meeting EUKARYOTIC DNA REPLICATION &GENOME MAINTENANCE Sept 1-5, 2015, New York USA

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㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊✲ㄢ㢟ྡᡃࠎࡣࠊᰁⰍయࡢ」〇ࢆ୰ᚰ࡟ࢤࣀ࣒ࡢᏳᐃ࡞⥔ᣢ࡜ఏ᧛࡟㛵୚ࡍࡿࢤࣀ࣒ไᚚ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࢆ┠ᣦࡋ࡚࠸ࡿࠋࡇࡢࡓࡵ࡟ࠊᰁⰍయ」〇ࢆไᚚࡍࡿࢤࣀ࣒㡿ᇦࢆྠᐃࡋࠊ㛵୚ࡍࡿᅉᏊ⩌ࡢヲ⣽࡞ゎᯒࢆ⾜ࡗࡓࠋᮏᖺ
ᗘࡣࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀ࡀ⣽⬊ෆ࡛ࡶᙧᡂࡉࢀࡿ஦ࢆド᫂ࡋࡓࠋࡲࡓࠊRif1ࡢᶵ⬟ࢻ࣓࢖ࣥࠊ᰾⭷࡜ࡢ┦஫స⏝࡟ᚲせ࡞࢔࣑ࣀ㓟㡿ᇦࢆྠᐃࡋࡓࠋG4
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▱ぢࢆデ᩿ࠊ᪂つ๰⸆ࠊไ⒴ᡓ␎㛤Ⓨ࡟⤖ࡧࡘࡅࡿࠋ

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ᅜෆእࡢ◊✲≧ἣ⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࡢ㑇ఏᏛⓗゎᯒࡣ⑌ᝈཎᅉ㑇ఏᏊࡢྠᐃ
࡟኱ࡁࡃ㈉⊩ࡋ࡚ࡁࡓࠋࡲࡓࠊࡑࡢᇶ┙࡜࡞ࡿࢤࣀ࣒᝟ሗࡣ
ᩚഛࡉࢀࠊࢤࣀ࣒ゎᯒᢏ⾡ࠊ㑇ఏᏊⓎ⌧ゎᯒᢏ⾡࠾ࡼࡧ㑇ఏᏊᨵኚ࣭ࢤࣀ࣒⦅㞟ᢏ⾡ࡶᛴ㏿࡟㐍Ṍࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊ」ᩘࡢ㔞ⓗᙧ㉁㑇ఏᏊᗙࡀ⤡ࡳྜࡗ࡚Ⓨ⑕ࡍࡿከᅉᏊ⑌ᝈ࡟࠾
࠸࡚ࡣࠊ⎔ቃせᅉࡢᙳ㡪ࢆཷࡅࡿࡇ࡜ࠊཎᅉ࡜࡞ࡿከᆺࡀ㠀ࢥ࣮ࢻ㡿ᇦ࡟Ꮡᅾࡍࡿࡇ࡜࠿ࡽ㑇ఏⓗせᅉࡢྠᐃࡀ࠸ࡲࡔ࡟
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࣐ࣝ࢘ࢫ࡟࠾࠸࡚㑇ఏᏛⓗゎᯒࡢࡓࡵࡢᢏ⾡㠉᪂࠾ࡼࡧ⌮ㄽᵓ⠏࡟ດࡵ࡚࠸ࡿࠋ

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ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Sci Rep, 9, 5285, 2019.
࣭ An Excursus into Hearing Loss, 1, 3–23, 2018.
࣭ ➨41ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018, ᶓ὾࣭ ➨28ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍, 2018, ኱㜰࣭ ➨65ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍, 2018, ᐩᒣ

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(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Ahl10㡿ᇦ࡟ᏑᅾࡍࡿB6J࣐࢘ࢫࡢARHLⓎ⑕ཎᅉೃ⿵㑇ఏᏊࡢከᆺࢆ
ࢤࣀ࣒⦅㞟ࡋࠊAhl10ࡢᐇែゎ᫂ࢆ┠ᣦࡍࠋ࣭ NOD ࣐࢘ࢫࡢSept10ࡢNOD≉␗ⓗኚ␗ࢆ㔝⏕ᆺ࡟⨨᥮ࡋࡓ࣐࢘ࢫ࠾
ࡼࡧࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆస〇ࡋࠊSept10ࡢNOD࣐࢘ࢫࡢ㞴⫈࡬ࡢ㛵୚࠾ࡼࡧ⫈ぬ⣔࡟࠾ࡅࡿᙺ๭ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ
࣭ Myo6-miExonǼ࣐࢘ࢫࡢ⾲⌧ᆺࢆࡼࡾヲ⣽࡟ゎᯒࡋࠊMyo6-miExonᤄධ࢔࢖ࢯࣇ࢛࣮࣒ࡢᶵ⬟ࢆゎ᫂ࡍࡿࠋ

Cdh23ࡢࢤࣀ࣒ከᆺ࡜ࡑࡢ㏆ഐ࡟఩⨨ࡍࡿ୰㧗࿘Ἴᩘ㡢ᇦࡢ⫈ຊ⥔ᣢ࡟ຠᯝࢆࡶࡘ㑇ఏᏊከᆺ࡟ࡼࡗ࡚Ⓨ⑕ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡉ ࡽ ࡟ ࠊ ᡃ ࠎ ࡣከ ᆺ ゎ ᯒ ࡟ࡼ ࡗ ࡚ ࠊ Septin 10㑇 ఏ Ꮚ 㸦 Sept10㸧 ࡟
NOD≉␗ⓗ࣑ࢫࢭࣥࢫኚ␗ࡀᏑᅾࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋճ ࣐࢖ࢡ࢚ࣟࢡࢯࣥᤄධMyosin VI࢔࢖ࢯࣇ࢛࣮࣒ࡢᶵ⬟ゎᯒᡃࠎࡣ㞴⫈Ⓨ⑕ཎᅉ㑇ఏᏊ࡛࠶ࡿ࣐࢘ࢫMyosin VI㸦Myo6㸧࡟9ሷᇶࡢ࣐࢖ࢡ࢚ࣟࢡࢯࣥ㸦miExon㸧ࡀᤄධࡍࡿ࢔࢖ࢯࣇ࢛࣮࣒ࡀෆ⪥࡟㧗Ⓨ⌧ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋ࡚࠸ࡿࠋᮏᖺᗘࡣmiExonࡢࢫࣉࣛ࢖
ࢩࣥࢢࢆࣈࣟࢵࢡࡋࡓMyo6-miExonǼ࣐࢘ࢫࡢෆ⪥ࡢ⾲⌧ᆺࢆゎᯒࡋ ࡓ ࠋ ࡑ ࡢ ⤖ ᯝ ࠊ Myo6-miExon Ǽ ࣐ ࢘ ࢫ ࡢ ⾲ ⌧ ᆺ ࡣ እ ᭷ ẟ ⣽ ⬊㸦OHC㸧࡛㔜⠜࡛࠶ࡿࡇ࡜ࠊ୙ືẟ㸦stereocilia㸧ࡢᙧᡂ఩⨨␗ᖖ࠾ࡼࡧືẟ㸦kinocilium㸧ࡢ⛣ື㞀ᐖࢆ♧ࡍࡇ࡜ࢆ✺ࡁṆࡵࡓࠋ

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㸦ᩍ⫱◊ಟ⏕㸧౳ 㞷ྵ
୕ᾆ㑳⏕㸦༠ຊ◊✲ဨ㸧
ዟᮧ࿴ᘯ
႐ከ▱Ꮚ
ᐑᆏຬ㍤
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ᯇỌ㐩㞝
࿴⏣೺ኴ

(2)

◊✲⪅ྡ
㸦ᖖ໅◊✲ဨ㸧
ྜྷᕝḠு
ᯇᒸ㑥ᯞ
Ᏻ⏣ಇᖹ
㛵 ඃኴ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ့ங㢮㑇ఏᏛࢆᇶ┙࡜ࡋࡓ⑌ᝈࡢཎᅉゎ᫂㸭့ங㢮㑇ఏࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ྜྷᕝḠு㸧ᴫせ(1) ᡂᯝࡢᴫせࣄࢺ⑌ᝈⓎ⑕࡜㑇ఏᏊኚ␗࡜ࡢ㛵㐃ࡣ㞴἞ᛶ⑌ᝈࢆ୰ᚰ࡟ ձ C57BL/6J ࣐࢘ࢫຍ㱋ᛶ㞴⫈Ⓨ⑕㛵㐃㑇ఏᏊࡢྠᐃ
C57BL/6J㸦B6J㸧࣐࢘ࢫࡣ」ᩘࡢ㑇ఏᅉᏊࡢ┦ຍⓗຠᯝ࡟ࡼࡗ࡚ຍ
ゎ᫂ࡉࢀࡘࡘ࠶ࡿࡀࠊ⎔ቃᅉᏊ࡜」ᩘࡢ㑇ఏᅉᏊࡢຠᯝ࡟ࡼ
㱋ᛶ㞴⫈㸦ARHL㸧ࢆⓎ⑕ࡍࡿࠋᡃࠎࡣB6JࡢARHLࡢ୺せཎᅉ࡛࠶ࡗ࡚Ⓨ⑕ࡍࡿࠕ࠶ࡾࡩࢀࡓ⑌ᝈࠖ࡟࠾ࡅࡿᐇド౛ࡣᴟࡵ࡚ᑡ
ࡿCadherin 23㑇ఏᏊ㸦Cdh23㸧ࡢࢤࣀ࣒ከᆺࠊ࠾ࡼࡧB6J࣐࢘ࢫࡢ➨2࡞࠸ࠋࡇࡢ≧ἣࢆᡴ㛤ࡍࡿࡓࡵ࡟ࡣࠊ⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࢆᇶ
ࡢARHLⓎ⑕㛵㐃㑇ఏᏊᗙ㸦Ahl10㸧ࡢ㏆ഐࢤࣀ࣒㡿ᇦࢆ㛗ᮇṇᖖ⫈┙࡜ࡋࡓ㡰㑇ఏᏛⓗ◊✲ࡀ᭷ຠ࡜࡞ࡿࠋຍ࠼࡚ࠊ࣐࢘ࢫࢆ⏝ຊ⥔ᣢ⣔⤫࡛࠶ࡿMSM/Ms࣐࢘ࢫࡢࢤࣀ࣒㡿ᇦ࡟⨨᥮ࡋࡓ࣐࢘ࢫ
࠸ࡓ㏫㑇ఏᏛⓗ◊✲ࡣࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓏሙ࡟ࡼࡾຠ⋡ⓗ
㸦B6J-Cdh23c.753A>G, Ahl10MSM 㸧ࢆస〇ࡋࠊ⾲⌧ᆺࢆゎᯒࡋࡓ⤖ᯝࠊ࡞⑌ᝈࣔࢹ࣐ࣝ࢘ࢫࡢస〇ࡀྍ⬟࡜࡞ࡗࡓࠋࡑࡇ࡛ᮏ◊✲ࡣ
B6J-Cdh23c.753A>G, Ahl10MSM ࣐࢘ࢫࡢ⫈ຊࣞ࣋ࣝࡣMSM࣐࢘ࢫ࡟ᴟࡵ
࣐࢘ࢫ㑇ఏᏛࡢ୧㍯࡛࠶ࡿ㡰࣭㏫㑇ఏᏛࢆᇶ┙࡜ࡋࠊ୺࡟⫈࡚㏆࠸್ࢆ♧ࡋࠊB6J࣐࢘ࢫࡢARHLࡣࡢCdh23࡜Ahl10㡿ᇦ࡟Ꮡᅾࡍ
ࡿከᆺࡢ┦ຍⓗຠᯝ࡛Ⓨ⑕ࡍࡿࡇ࡜ࡀಶయ࡛ࣞ࣋ࣝᐇドࡉࢀࡓࠋ
ぬ⑌ᝈࢆᶆⓗ࡜ࡋࡓ⑌ᝈⓎ⑕ཎᅉ࣭㛵㐃㑇ఏᏊࡢྠᐃ࠾ࡼࡧ
⑌ᝈⓎ⑕ᶵᗎゎ᫂࡟᭷⏝࡞ࣔࢹ࣐ࣝ࢘ࢫࡢᶞ❧ࢆ┠ⓗ࡟◊✲ ղ NOD/Shi࣐࢘ࢫࡢ᪩Ⓨᛶ㔜ᗘ㞴⫈Ⓨ⑕ཎᅉ㑇ఏᏊࡢ᥈⣴㑇ఏゎᯒ࡟ࡼࡗ࡚NOD/Shi㸦NOD㸧࣐࢘ࢫࡢ᪩Ⓨᆺ㔜ᗘ㞴⫈ࡣࠊࢆᒎ㛤ࡍࡿࠋ

୺࡞◊✲ᡂᯝ

－ 11 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࡟ᑐࡋ࡚༶᫬ⓗ࡞㜵ᚚຠᯝࢆⓎ᥹ࡍࡿ࣡ࢡࢳࣥࡢ㛤Ⓨࡀᮃࡲࢀ࡚࠸ࡿࠋ
ࣄࢺ࡬ᛂ⏝ྍ⬟࡞⫢◳ኚ἞⒪⸆ࡢ㛤Ⓨࡀᚲ㡲࡛࠶ࡿࠋ἞⒪⸆ೃ⿵ࡀ」ᩘሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊఱࢀࡶ⥺⥔໬ᢚไᶵᗎࢆᶆ
ⓗ࡜ࡋ࡚࠸ࡿⅭࠊ᰿ᮏⓗ࡞἞⒪ຠᯝࡣᚓࡽࢀ࡚࠸࡞࠸ࠋ
⌧ᅾㄆྍࡉࢀ࡚࠸ࡿࢹࣥࢢ⇕࣡ࢡࢳࣥࡣࠊᮍឤᰁ⪅࡬ࡢ᥋✀࡟ࡼࡾ࢘࢖ࣝࢫึឤᰁᚋ࡟ࡼࡾ㔜⑕໬ࡍࡿࣜࢫࢡࡀሗ࿌ࡉ
ࢀࡓⅭࠊసᴗᶵᗎࡢ␗࡞ࡿ࣡ࢡࢳࣥࡢ㛤Ⓨࡀᮃࡲࢀ࡚࠸ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Sanada T, et al. Virology 2019; 592:101-110.
࣭ Okamoto M, et al. J Biol Chem.2018; 293(48) 18585–18600
࣭ Nishitsuji H, et al. Cancer Sci. 2018; 109(1):241-249(1)

ᴫせH5N1㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡸH7N9㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢࣄࢺ࡛ࡢឤᰁ౛࡜Ṛஸ౛ࡀሗ࿌ࡉࢀ࡚࠸
ࡿࠋ୓ࡀ୍ࣄࢺ࡛ࡢឤᰁὶ⾜ࡀⓎ⏕ࡋࡓ㝿࡟ࡣࠊ⏒኱࡞⿕ᐖࢆࡶࡓࡽࡍⅭࠊ᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࡬ࡢᑐ⟇ࡣᛴົ࡛࠶ࡿࠋ
ᅜෆࡢ⫢◳ኚཬࡧ⫢⒴Ṛஸ⪅ᩘࡣࠊᖺ㛫1୓ேཬࡧ3୓ேࢆ㉸࠼࡚࠸ࡿࠋࡑࡢᡂᅉࡣࠊBᆺ⫢⅖࢘࢖ࣝࢫ㸦HBV㸧ཬࡧCᆺ⫢⅖࢘࢖ࣝࢫ㸦HCV㸧ឤᰁࠊ࡞ࡽࡧ࡟⬡⫫ᛶ⫢⅖࡛࠶ࡿࠋ
HBV࡟ᑐࡋ࡚ࡣࠊ᰿ᮏⓗ࡞἞⒵ࡀྍ⬟࡞἞⒪ࡣࡲࡔ࡞࠸ࠋᢠ
࢘࢖ࣝࢫ⸆࡟ࡼࡾHCV᤼㝖ࡀྍ⬟࡜࡞ࡗࡓࡀࠊ㧗㢠࡞἞⒪㈝ࡀၥ㢟࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ⫢◳ኚࡸ⫢⒴Ⓨ⑕ᝈ⪅࡟ᑐࡍࡿ἞⒪ἲࡣᮍࡔ㛤Ⓨࡉࢀ࡚࠸࡞࠸ࠋࡼࡗ࡚ࠊࡇࢀࡽ⫢⑌ᝈ࡟ᑐࡍࡿᏳ඲࠿ࡘຠᯝⓗ࡛Ᏻ౯࡞᪂つ἞⒪ἲࡢ㛤Ⓨཬࡧண㜵ἲࡢ☜❧ࡣࠊ㔜኱࠿ࡘ⥭ᛴⓗ࡞♫఍せㄳ࡛࠶ࡿࠋ
ࡲࡓࠊ2014ᖺ࡟Ⓨ⏕ࡋࡓࢹࣥࢢ⇕ࡢᅜෆឤᰁ஦౛ࡣࠊ ᖏᆅᇦ࡛࠶ࡿ᪥ᮏᅜෆ࡛ࡶኟᏘ࡛࠶ࢀࡤឤᰁᣑ኱ࡋᚓࡿ஦ࢆ♧ࡋ࡚࠾ࡾࠊࡑࡢᑐ⟇ࡶᛴࡀࢀࡿ

୺࡞◊✲ᡂᯝ

࢖ࣥࣇ࢚ࣝࣥࢨᡂᯝࡢᴫせ✲       ᡂ
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E

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⫢⅖

៏ᛶ⫢⅖ࡢච␿Ꮫⓗ἞⒪ἲࡢ☜❧ࡍࡿⅭࠊ࣡ࢡࢳࣥᢠཎࡸ᥋✀᪉ἲࡢ᳨ウ࡜స⏝ᶵᗎࡢゎᯒࢆ㐍ࡵࡿࠋ࣭ ᪂つࢹࣥࢢ࣡ࢡࢳࣥࡢࢹࣥࢢ࢘࢖ࣝࢫ2Cᆺ࡟ᑐࡍࡿண㜵ຠᯝࡀ☜ㄆࡉࢀࡓⅭࠊ1㹼4ᆺ඲࡚ࡢ⾑Ύᆺ࡟ᑐࡍࡿண㜵ຠᯝ࡜㜵ᚚᶵᗎࢆゎᯒࡍࡿࠋ࣭ ⫢⥺⥔⑕἞⒪⸆ೃ⿵PRI-724ࡀ♧ࡍస⏝ᶵᗎࡢࡼࡾヲ⣽࡞ゎ᫂ࢆ┠ᣦࡍࠋCᆺຊ࡞ண㜵ຠᯝࢆᣢࡘ⤌᥮࠼࢖ࣥࣇ࢚ࣝࣥࢨ࣡ࢡࢳࣥࡢస⏝ᶵᗎࢆゎᯒࡍࡿࠋ(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ 」ᩘࡢ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫளᆺ࡟ᑐࡍࡿⓎ⑕ண㜵ຠᯝࡢ᳨ウ࡜㠀ᖖ࡟ᙉ࣭ HCVㄏ Ⓨᛶ ⫢⥺ ⥔⑕ࣔ ࢹࣝ ࣐࢘ ࢫ࡟ ຍ࠼ࠊ ࢥࣜࣥ Ḟஈ 㣗࡟ࡼ ࡾㄏ Ⓨࡋࡓ
NASH⫢⥺⥔⑕ࣔࢹ࣐ࣝ࢘ࢫࢆ⏝࠸࡚ࠊȕ-catenin/CBP㑅ᢥⓗ㜼ᐖ๣PRI-724ࡢᢠ⧄⥔໬ຠᯝ࡜ࡑࡢస⏝ᶵᗎࢆゎᯒࡋࡓࠋPRI-724ᢞ୚࡟ࡼࡾࠊNASHㄏⓎᛶ⫢⤌⧊ᵓ㐀ኚᛶ࡜ࣉࣟࢺࣟࣥࣅࣥ᫬㛫ᘏ㛗ࢆᨵၿ࡛ࡁࡓࠋࡲࡓࠊ⥺⥔ศゎ⤒㊰࡛࠶ࡿMMP-8/MMP-9ࡢ⏘⏕ஹ㐍ࡀ㛵୚ࡋ࡚࠸ࡿ஦ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ᭦
࡟ࠊඹྠ◊✲ᶵ㛵࡛࠶ࡿ㒔❧㥖㎸⑓㝔࡟࠾࠸࡚ࠊCᆺ⫢◳ኚᝈ⪅ࢆᑐ㇟࡜ࡋ
ࡓ་ᖌ୺ᑟࡢ⮫ᗋ➨஧┦ヨ㦂ཬࡧBᆺ⫢◳ኚᝈ⪅ࢆᑐ㇟࡜ࡋࡓ⮫ᗋ➨୍┦ヨ㦂ࡀ㛤ጞࡉࢀࡓࠋ࣭ ࡼࡾᙉຊ࡞ឤᰁ㜵ᚚຠᯝࢆ♧ࡍHBV࣡ࢡࢳࣥࡢ㛤Ⓨࢆ┠ᣦࡋࠊ␗࡞ࡿ2✀㢮ࡢ㑇ఏᏊᆺ⏤᮶ࡢHBs-LࢆྵࡴHBs-L hybrid (Lh)ࢆ࣐࢘ࢫ࡟᥋✀ࡋࡓࠋHBsLh᥋✀⩌࡛ࡣࠊ」ᩘࡢࢪ࢙ࣀࢱ࢖ࣉࡢHBV࡟ᑐࡋ࡚ᙉ࠸୰࿴ᢠయࡀㄏᑟࡉࢀ
ࡓࠋ᭦࡟ࠊ⌧⾜࣡ࢡࢳࣥࡢ࢚ࢫࢣ࣮ࣉኚ␗ᰴ࡟ᑐࡋ࡚ࡶ୰࿴άᛶࢆ♧ࡋࡓࠋղ࣭ 㟋㛗㢮ࣔࢹ࡛ࣝ࠶ࡿ࢝ࢽࢡ࢖ࢨࣝࢆ⏝࠸࡚ࠊ࣡ࢡࢳࣥ᥋✀᪉ἲࢆᚑ᮶ࡢ஧ཫ
㔪࠿ࡽ⓶ෆ᥋✀࡟ኚ᭦ࡋ࡚༶᫬ᛶ㜵ᚚຠᯝࢆ᳨ウࡋࡓࠋ᭦࡟ࠊrDIs-H1 HA, H3 HA, -H5 HA , -H7 HAࢆ㸲౯ΰྜ᥋✀ࡋࡓ㝿ࡢH7N9࢘࢖ࣝࢫឤᰁ࡟ᑐࡍࡿ
༶᫬ᛶ㜵ᚚຠᯝ࡬ࡢᙳ㡪ࡶేࡏ࡚ホ౯ࡋࡓࠋ஧ཫ㔪ࡢ௦᭰ἲ࡜ࡋ࡚⓶ෆ᥋✀ࢆ⾜࡞ࡗࡓ⤖ᯝࠊࢥࣥࢺ࣮ࣟࣝ⩌࡟ẚ࡭࡚ࠊrDIs-H7 HA᥋✀⩌࡛ࡣࠊ㏿ࡸ࠿࡞ゎ⇕ࠊᣔ࠸ᾮ୰ཬࡧ⫵୰ࡢ࢘࢖ࣝࢫ౯ ࡢ᤼㝖ຠᯝࡀㄆࡵࡽࢀࡓࠋࡲࡓࠊ4౯ΰྜ᥋✀⩌࡟࠾࠸࡚ࡶࠊྠ➼ࡢ㜵ᚚຠᯝࡀㄆࡵࡽࢀࡓ஦࠿ࡽࠊrDIs-࣡ࢡࢳࣥࡢ᥋✀ἲ࡜ࡋ࡚ࠊ⓶ෆ᥋✀ࡢ᭷ຠᛶࡀ㟋㛗㢮ࣔࢹ࡛ࣝࡶ☜ㄆ࡛ࡁࡓࠋ࣭ ᪂つࡢ࢖ࣥࣇ࢚ࣝࣥࢨ⑓ែゎᯒࣔࢹࣝࢆ᥈⣴ࡍࡿ┠ⓗ࡛ࠊᑠᆺື≀ࢶࣃ࢖࡬
H5N1࢘࢖ࣝࢫཪࡣH7N9࢘࢖ࣝࢫࢆྠ୍࢘࢖ࣝࢫຊ౯࡛ឤᰁࡉࡏࠊឤᰁ㒊఩࡛ࡢ⤒᫬ⓗ࢘࢖ࣝࢫ㔞ኚ໬࡜⫵⑓⌮ゎᯒࢆ⾜࡞ࡗࡓࠋୖẼ㐨࡛ࡢቑṪᛶࡣ
H7N9࢘࢖ࣝࢫࡀඃ఩࡛࠶ࡗࡓࡢ࡟ᑐࡋ࡚ࠊ⫵⅖㔜⑕໬ࡣࠊH5N1࢘࢖ࣝࢫឤᰁಶయ࡛ぢࡽࢀࡓࠋࢶࣃ࢖ࡀ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫឤᰁᑠᆺື≀ࣔࢹࣝ࡜ࡋ࡚᭷⏝࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓࠋ

(1)
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(1)

◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

࢖ࣥࣇ࢚ࣝࣥࢨཬࡧ㹀ᆺ࣭㹁ᆺ⫢⅖࢘࢖ࣝࢫឤᰁ⑕ࡢண㜵࡜἞⒪㸭ឤᰁไᚚࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸Ᏻ஭ᩥᙪ㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 12 －

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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠụ ᬛ㸧
A

EV71ࣞࢭࣉࢱ࣮㑇ఏᏊ༢㞳ࡣୡ⏺࡛ᡃࠎࡀࡣࡌࡵ࡟ᡂຌ
ࡋࡓࠋ௒ᖺᗘࡣື≀ࣔࢹࣝࢆ⏝࠸ࡓ࢘࢖ࣝࢫࡢẘຊࡢホ౯࡟㛵ࡍࡿ◊✲ࡀ㐍ᒎࡋࡓࠋᅜෆእ࡛ࡇࡢࡼ࠺࡞௙஦ࡣ࡞
࠸ࠋEV71࣡ࢡࢳࣥࡢ㛤Ⓨࡣ୰ᅜ࡛ᐇ⏝໬ࡉࢀࡓࡀࠊ⏕⏘㔞࡞࡝ࡢၥ㢟ࡀ࠶ࡿࡓࡵࠊ௒ᚋࡉࡽ࡞ࡿᨵⰋࡀ࡞ࡉࢀࡓ࣡ࢡ
ࢳࣥࡀᚲせ࡜ࡉࢀ࡚࠸ࡿࠋ

(1)

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࢘࢖ࣝࢫឤᰁࡢ࣓࢝ࢽࢬ࣒࡟ᇶ࡙࠸ࡓ἞⒪⸆➼ࡢ㛤Ⓨ㸭࢘࢖ࣝࢫឤᰁࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ(1) ◊✲ᮇ㛫ᴫせ(1) ᡂᯝࡢᴫせ࢚ࣥࢸࣟ࢘࢖ࣝࢫ71(EV71)ࠊ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫ࡞ ࣭ᅜෆ࡞ࡽࡧ࡟ᾏእ࡛ศ㞳ࡉࢀࡓከᩘࡢEV71⮫ᗋศ㞳ᰴࡢሷ 2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧࡝ᛴᛶࡢ࢘࢖ࣝࢫឤᰁ⑕ࡢ」〇ᶵᵓࠊ⑓ཎᛶⓎ⌧ᶵᵓࢆㄪᇶ㓄ิࢆḟୡ௦ࢩ࣮ࢡ࢚ࣥࢧ࣮ࢆ⏝࠸࡚Ỵᐃࡋࠊẘຊࢆ
࡭἞⒪⸆➼ࢆ㛤ⓎࡍࡿࠋEV71࡜ࡑࡢཷᐜయ࡜ࡢ┦஫స⏝SCARB2tg࣐࢘ࢫࢆ⏝࠸࡚Ỵᐃࡋࡓࠋศ㞳ࡉࢀࡓᰴࡢ࡯࡜ࢇ (2) ◊✲⪅ྡࢆㄪ࡭ࡿࡇ࡜ࠊEV71ឤᰁື≀ࣔࢹࣝࢆస〇ࡍࡿࡇ࡜ࠊ࢖
࡝ࡣsubgenogroup B5࠿C4࡟ศ㢮ࡉࢀࡿᰴ࡛࠶ࡗࡓࡀࠊᖹᆒ ᑠụ ᬛࣥࣇ࢚ࣝࣥࢨ⸆ࡢ࣏࣓࣮ࣜࣛࢮάᛶࢆ㜼ᐖࡍࡿᢠ࢖ࣥࣇࣝ
ⓗ࡟ࡣC4ᰴࡀ⑓ཎᛶࡀ㧗࠸ഴྥࡀ࠶ࡗࡓࠋ
ᑠᯘ㒓௓࢚ࣥࢨ⸆ࢆ㛤Ⓨࡍࡿࡇ࡜࡞࡝ࡀ┠ᶆ࡛࠶ࡿࠋ࣭SCARB2tg࣐࢘ࢫ࡜࣊ࣃࣛࣥ◲㓟ྜᡂ㓝⣲ࢆࠊࣀࢵࢡ࢔࢘ࢺ
⣽⬊ࢆ⏝࠸࡚ᇵ㣴ࡋࡓ࢘࢖ࣝࢫࢆ⏝࠸ࠊEV71࣡ࢡࢳࣥࡢ᭷
ຠᛶヨ㦂ࡀ෌⌧ᛶࡼࡃ⾜࠼ࡿᐇ㦂⣔ࢆ☜❧ࡋࡓࠋ௒ᖺᗘࡣ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
EV71ࡢ࡯࠿࡟CVA16࡟ࡘ࠸࡚ࡶ᭷ຠᛶヨ㦂ࡀ⾜࠼ࡿࡼ࠺࡟
࣭ Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K,࡞ࡗࡓࠋࡇࡢࢩࢫࢸ࣒ࢆ⏝࠸࡚ඹྠ◊✲࡟ࡼࡾ࣡ࢡࢳࣥࡢ㛤
Koike S㸸Amino acid variation at VP1-145 of enterovirus
71 determines attachment receptor usage and neurovirulenceⓎࢆ⾜ࡗࡓࠋ
in human scavenger receptor B2 transgenic mice. J. Virol.
92: e00681-18, 2018㸦ᰝㄞ᭷㸧(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, ࣭ᙉẘᰴ࡜ᙅẘᰴࡢ௦⾲ᰴࢆ㑅ᐃࡋࠊࡇࢀࡽࡢ௦⾲ᰴ㛫ࡢ࢟Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu࣓ࣛ࢘࢖ࣝࢫࢆస〇ࡋࠊ⑓ཎᛶࡢᙉࡉࢆỴᐃࡋ࡚࠸ࡿ࢘࢖
H, Nagata N, Mizuta K, Matsuzaki Y, Koike S: VP1 aminoࣝࢫഃせᅉࢆヲ⣽࡟᫂ࡽ࠿࡟ࡍࡿࠋ
acid residue 145 of enterovirus 71 is a key residue for its
࣭☜❧ࡋࡓ࣡ࢡࢳ᳨ࣥᐃ⣔ࢆά⏝ࡋࠊ௻ᴗ࡜ࡢඹྠ◊✲ࢆ⾜
receptor attachment and resistance to neutralizing antibody
࠸⌧ᅾ㛤Ⓨ୰ࡢᡭ㊊ཱྀ⑓࣡ࢡࢳࣥࡢࡉࡽ࡞ࡿᨵⰋࢆ⾜࠺ࠋ
during cynomolgus monkey infection. J. Virol. 92: e00682࣭ࡉࡽ࡟CVA6,
CVA10ࡢ」〇࡟ᚲせ࡞ᐟ୺ᅉᏊࢆྠᐃࡋࠊࡇ
18, 2018㸦ᰝㄞ᭷㸧ࢀࡽࡢ࢘࢖ࣝࢫ࡟ࡶឤཷᛶࢆࡶࡘື≀ࣔࢹࣝࢆ㛤Ⓨࡍࡿࠋ
㛤Ⓨࡋࡓ࣐࢘ࢫࣔࢹࣝࢆ࣡ࢡࢳࣥ㛤Ⓨ࡟ᙺ❧࡚ࡿࠋ(3) ᅜෆእࡢ◊✲≧ἣ୺࡞◊✲ᡂᯝ

－ 13 －

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Nishimura T, et al.Effects of anti-allergic drugs on T cellmediated nasal hyperresponsiveness in a murine model ofallergic rhinitis. Allergol Int. 6
Gotoh M, et al. Microarray-based multivariate analysis of theeffectiveness of sublingual immunotherapy for cedar pollinosis.
Allergy Asthma Immunol Res.   
Shimada K, et al. Serum cytokine interactions are implicated in
the mechanism of action of sublingual immunotherapy forjapanese cedar pollinosis. Journal of Nippon Medical School.
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᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍⥲఍ 2018.

(3)ᅜෆእࡢ◊✲≧ἣ⯉ୗච␿⒪ἲࡣ᪤࡟ᅜෆእ࡛ᐇ᪋ࡉࢀ࡚࠸ࡿ࢔ࣞࣝࢠ࣮ච
␿⒪ἲ࡛࠶ࡿࠋࡋ࠿ࡋ࡞ࡀࡽ἞⒪ᮇ㛫ࡀ㛗ᮇ㸦3㹼5ᖺ௨ୖ㸧࡟Ώࡿ࡟ࡶ࠿࠿ࢃࡽࡎࠊࡑࡢ἞⒵⋡ࡣ⣙60%⛬ᗘ࡛࠶ࡾỴࡋ࡚ᝈ⪅࡟࡜ࡗ࡚‶㊊࠸ࡃ⤖ᯝ࡛ࡣ࡞࠸ࠋࡑࡇ࡛ࠊస⏝࣓࢝ࢽ
ࢬ࣒ࡢヲ⣽ࢆゎ᫂ࡋ࡚἞⒪ࡢຠᯝࢆண ࡍࡿデ᩿ࡢ㛤Ⓨࡣ㔜
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(1)

ᴫせ
ᖹᡂ26ᖺ࡟ࠊࢫࢠⰼ⢊⑕⯉ୗච␿⒪ἲࡀಖ㝤་⒪࡜ࡋ࡚㐺ᛂࡉࢀࠊ⣙㸴๭ࡢᝈ⪅࡟ຠᯝࢆㄆࡵࡓࠋ୍᪉࡛ච␿Ꮫⓗస⏝࣓࢝ࢽࢬ࣒ࡀᮍࡔᮍゎ࡛᫂࠶ࡿࠋᮏ◊✲ࡣࠊ⯉ୗච␿⒪ἲࡢ
ዌຌ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋ἞⒪ຠᯝࡢ᭷ຠᛶࢆ஦๓࡟᳨ウࡍࡿ᪉ἲࢆ㛤Ⓨࡍࡿࡇ࡜࡛࠶ࡿࠋࡑࢀ࡟ࡼࡾࠊ㧗࠸἞⒪ຠᯝࢆ┠ᣦࡋࠊಶࠎࡢᝈ⪅࡟ᑐࡍࡿ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡢ㛤Ⓨࢆ⾜࠸ࠊ⯉ୗච␿⒪ἲ࡟᭦࡞ࡿⴭຠࢆ♧ࡍ᪂⸆ࡢ㛤Ⓨ◊✲ࢆᒎ㛤ࡋ࡚࠸ࡃࠋ୺࡞◊✲ᡂᯝ✲       ᡂ
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(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ձ ⯉ୗච␿⒪ἲࡢ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡢ㛤Ⓨ࣭ TAS2R43ࢆᙉไⓎ⌧ࡉࡏࡓ⣔ࢆ⏝࠸࡚ࠊྛTAS2R࡟≉␗ⓗ࡞ࣜ࢞ࣥࢻ࡟ᑐࡍࡿ⣽⬊ᛂ⟅ࢆホ౯ࡋࠊᙺ๭ࢆ᫂ࡽ࠿࡟ࡍࡿࠋࡇࢀ࡟ࡼࡾࠊ
ຠᯝⓗ࡞ච␿ㄏᑟࢆ㉳ࡇࡍங㓟⳦ࡸ࣑࣮ࣗࢱࣥࢫ⳦ࡢศἪ≀ࡸᵓᡂᡂศࢆぢฟࡋࠊࡑࢀࡽࡢ᭷ຠᡂศࡢゎᯒࢆ⥆⾜ࡋ࡚࠸ࡿࠋࡲࡓࠊ࣐
࢘ࢫࡢⱞ࿡ࣞࢭࣉࢱ࣮Ḟᦆ࣐࢘ࢫࢆసᡂࡋࠊࡇࡢศᏊ࡟࠾ࡅࡿච␿
Ꮫⓗ㛵㐃ᛶࢆ᳨ウࡋࠊ⎔ቃᅉᏊ㸦㣗஦ࡸཱྀ⭍ෆ⎔ቃ࡞࡝㸧࡟ᙳ㡪ࡉࢀࡿಶࠎࡢච␿≧ែࢆぢᴟࡵࡿ◊✲ࢆᒎ㛤ࡍࡿࠋղ ⾑⟶⅖⑕ೃ⩌࡟࠾ࡅࡿ⑓ែゎ᫂࡜᪂つ἞⒪ἲࡢ㛤Ⓨ࣭ ⭺ཎ⑓ࢆྵࡴ⮬ᕫච␿⑌ᝈࡣࠊ࢔ࣞࣝࢠ࣮࡜ྠᵝࠊච␿ࢩࢫࢸ࣒ࡢ
␗ᖖࢆ㉳ᅉ࡜ࡍࡿࠋGCAࡢ⑓ែゎ᫂࡟ྥࡅഃ㢌ື⬦⏕᳨㸦TAB㸧ࡣ᭱ࡶ㈗㔜࡞ࢧࣥࣉ࡛ࣝ࠶ࡿࠋTAB࠾ࡼࡧᮎᲈ⾑ᡂศࢆ⏝࠸ࡓ⥙⨶ⓗゎᯒ࡟ࡼࡾ⑌ᝈ≉␗ⓗ࡞ᶆⓗศᏊࠊࣂ࢖࣐࣮࣮࢜࢝ࡢྠᐃࢆ⾜࠺ࠋࡑࡢ⤖ᯝࠊ᪂つ἞⒪ἲ࠾ࡼࡧ㠀౵くⓗ࡞デ᩿ἲࡢ㛤Ⓨࡀᮇᚅࡉࢀ
ࡿࠋࡉࡽ࡟ࠊ௚ࡢ⾑⟶⅖ࢆྵࡵࡓomicsゎᯒࢆ㐍ࡵࡿࡇ࡜࡟ࡼࡾࠊᕧ
⣽⬊ࡢ㉳※࡜ᶵ⬟ࢆゎ᫂ࡍࡿ◊✲ࢆᒎ㛤ࡍࡿ࡜ඹ࡟ࠊ⾑⟶⅖⑕ೃ⩌࡟࠾ࡅࡿ⑌ᝈ࢜ࣥࢺࣟࢪ࣮ᵓ⠏ࢆ┠ᣦࡍࠋ(1) ᡂᯝࡢᴫせձ ⯉ୗච␿⒪ἲࡢ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡢ㛤Ⓨ࣭ ⯉ୗච␿⒪ἲࡢ἞⒪ຠᯝ࡟㛵ࢃࡿࣂ࢖࣐࣮࣮࢜࢝ࡢೃ⿵࡜ࡋ࡚5✀ࡢⱞ࿡ࣞࢭࣉࢱ࣮ (TAS2R)ࡀぢฟࡉࢀࡓࠋ≉࡟ࠊTAS2R43ࡣ≉␗ⓗࣜ࢞ࣥࢻ࡜཯ᛂࡋ࡚in vitro࡛ࡢᢠཎ≉␗ⓗ࣊ࣝࣃ࣮T⣽⬊ࡢቑṪࢆᢚไࡍࡿࡇ࡜ࢆぢฟࡋࠊࢫࢠⰼ⢊⑕࡟࠾ࡅࡿච␿ᢚไ࡟࠾࠸࡚㔜せ࡛࠶ࡿྍ⬟ᛶࢆㄆࡵࡓࠋ
ղ ⾑⟶⅖⑕ೃ⩌࡟࠾ࡅࡿ⑓ែゎ᫂࡜᪂つ἞⒪ἲࡢ㛤Ⓨ࣭ ௒ᖺᗘࡼࡾ㒔❧⑓㝔㐃ᦠ◊✲࡜ࡋ࡚⭺ཎ⑓ࡢ୍✀࡛࠶ࡿᕧ⣽⬊ᛶື
⬦⅖(GCA)ࡢ◊✲ࢆ㛤ጞࡋࡓࠋᮾி㒔㛵㐃⑓㝔㸦㒔❧ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮࣭ከᦶ໭㒊་⒪ࢭࣥࢱ࣮࣭ከᦶ༡㒊ᆅᇦ⑓㝔㸧࡜ࡢඹྠ࡛
ഃ㢌ື⬦⏕᳨࠾ࡼࡧ⾑ᾮ᳨యࢆ⏝࠸ࡓ⑓ែゎ᫂࠾ࡼࡧ἞⒪࣭デ᩿ἲࡢ㛤Ⓨࢆ┠ⓗ࡜ࡍࡿ◊✲ࢢ࣮ࣝࣉࢆ❧ࡕୖࡆࡓࠋࣄࢺ᳨యࢆᦙ㏦ࠊ
ಖᏑࡍࡿయไࢆᵓ⠏ࡋࡓࠋࡲࡓࠊࣄࢺ⾑ᾮࢧࣥࣉࣝࡢศ⏬ἲࡢ☜❧࠾ࡼࡧ࣐࢘ࢫ⾑⟶ࢆ⏝࠸ࡓணഛ᳨ウࢆ⾜࠺࡜ඹ࡟ࠊࣄࢺ⾑ᾮࢧࣥࣉࣝࢆ⏝࠸ࡓ࣐࢖ࢡࣟ࢔ࣞ࢖࡟ࡼࡿ⥙⨶ⓗ㑇ఏᏊⓎ⌧ゎᯒࢆ㐍ࡵࡓࠋ◊㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᘅ஭㝯ぶ㸧E▱ᛕ┤ྐ㸦ከᦶ༡㒊ᆅᇦ⑓㝔㸧ᮡཎㄔே㸦ᮾி㒔ከᦶ໭㒊ࢭࣥࢱ࣮
⑓㝔㸧
႐℩㧗ᗤ
㸦ᮾி㒔ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮㸧ᩪ⸨┿つ㸦᪥ᮏ኱Ꮫ㸧ඵᮧᩄᚿ㸦ᮾி኱Ꮫ㸧኱ஂಖබ⿱ᚋ⸨ ✨ᑠ⏫ኴ㑻ᮧୖு௓㸦᪥ᮏ་⛉኱Ꮫ㸧⚄἟ ಟ㸦ᒣ᲍኱Ꮫ㸧

(2)

◊✲⪅ྡ
Ώ㎶ఙᫀ
బ఑┿ᘪ
すᮧ཭ᯞ
໭ᮧ⣖Ꮚ
㸦་Ꮫ◊㸧

◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

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(1)A⢓⭷ච␿࡟ࡼࡿⰼ⢊⑕➼࢔ࣞࣝࢠ࣮⑌ᝈࡢ἞⒪ἲ㸭ⰼ⢊⑕ࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 14 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ✲       ᡂ
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E

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(1) ᡂᯝࡢᴫせ࣭ ప㓟⣲཯ᛂᛶᅉᏊHIF2ࡢㄪ⠇ᅉᏊInt6ࡢsiRNAࢆᐇ⏝໬ࡍࡿࡓࡵ ࠊ siRNA ࡢ Ᏻ ᐃ ໬ ἲ ࡜ ࡋ ࡚ ⌮ ⛉ ኱ Ꮫ ࡜ ඹ ྠ ◊ ✲ ࡟ ࡚
ODAGal4࡜ࡢే⏝࡛㛗ᮇ㛫ࡢᏳᐃ໬ἲࢆⓎぢࡋࡓࠋ࣭ ⣽⬊⼥ྜ࡟ࡼࡿ⒴໬ࡢ◊✲࡛ࡣࠊ᪂ࡓ࡞ᶆⓗᅉᏊࡀぢࡘ࠿
ࡾࠊ⒴໬࡟࠾ࡅࡿ⣽⬊⼥ྜࡸ⣽⬊ࡢఇ╀≧ែ࡟㛵ࡍࡿ᪂ࡓ࡞
▱ぢࡀᚓࡽࢀࡓࠋ࣭ 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨࡢ᪂ࡋ࠸౵ධ⤒㊰࡟㛵ࢃࡿHAࡢ㓄ิࡀస〇ࡋࡓᢠయ࡟ࡼࡾྠᐃ࡛ࡁࡓࠋ࣭ ᮾ㒊ᆅᇦ⑓㝔࠿ࡽࡢせᮃ࡛ࠊᢠࡀࢇ๣5-FUࡢ⾑୰ ᐃ⡆᫆࢟ࢵࢺࡢヨస∧ࡀ᏶ᡂࡋࡓࠋ

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(2)

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㸦ከᦶᑠඣ་⒪ࢭࣥࢱ࣮㸧㛗㇂ᕝ⾜ὒ
ᮏ⏣㞞ᩗࠊ௚
㸦ᮾ㒊ᆅᇦ⑓㝔㸧ᰙᒣᑦ⣖ࠊⴠྜ ໶㸦㥖㎸⑓㝔㸧㯮஭ඞ᫂ᇼཱྀ┿୍㑻 
ᮌᮧබ๎
኱⃝㝧௓
ẚᓥᜏ࿴

(2) ◊✲⪅ྡ㸦་Ꮫ◊㸧Ⱚ㷂 ኴࠊྑ⏣ᩄ㑻኱ಖᮌၨ௓ࠊᲚཎ┤ᶞ⏣ᓥ㝧୍ࠊᕝᓥ⫱ኵධỤ ᩔࠊ㰺⸨⣪ᕼࠊෆ⸨ᬡᏹࠊḈ஭ 㝧㔝ᮧዉ⨾Ꮚࠊᑠᕝ⨾ዉ㐲⸨඾Ꮚࠊ᪩ᕝⱥẎ᳃ᐿⰾோࠊᏱᲚ㯞⣪Ꮚ⣽ᕝᖾ⏕ࠊΎỈ㐩ဢ୰㔝᪩▱ᰤࠊᶫᮏᣅஓ㈆௵኱ᆅࠊୖ⏣ᙬ஀኱ᒇ཭⣖ࠊᮾ ▖ᖹ㛫༓ὠᏊ 㞵㈅㝧௓(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾࡀࢇ࣭ឤᰁ⑕ࡢศᏊᶆⓗ᥈⣴࡟ࡼࡿデ᩿࣭἞⒪ἲࡢ㛤Ⓨ㸭ศᏊ་⒪ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸Ⱚᓮ ኴ㸧௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ HIF2ࢆ௓ࡍࡿ⾑⟶᪂⏕ࡢㄪ⠇ᶵᗎ࡟࠾࠸࡚ࠊInt6-siRNAࡢ⤖(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ྜ≀㉁࡜ࡋ࡚ࡢODAGal4ࡢຠᯝࡣࠊண᝿௨ୖ࡟ᙉࡃᵝࠎ࡞ࢱ
࢖ࣉࡢsiRNA࡟౑⏝࡛ࡁࡿࡇ࡜ࡀド࡛᫂ࡁ≉チࢆ⏦ㄳࡋࡓࠋㄽᩥᥖ㍕௒ᚋࡣࠊື≀ᐇ㦂➼࡛యෆ࡛ࡢᏳᐃᛶࢆド᫂ࡋ࡚࠸ࡃࡇ࡜ࢆ
࣭ Sadato D, et al.FEBS Open Bio. 2018.
ணᐃࡋ࡚࠸ࡿࠋ
࣭ Li Q , et al. Sci Rep. 2018Ꮫ఍
࣭ ⣽⬊⼥ྜ࡟ࡼࡿ⣽⬊ࡢఇ╀໬ࠊ࠶ࡿ࠸ࡣᝏᛶ໬ࡣࠊᵝࠎ࡞࢖࣭ ➨139ᅇ᪥ᮏ⣙Ꮫ఍ࠊ2018.3.20 ༓ⴥ┴༓ⴥᕷࣥࢱ࣮ࣇ࢙ࣟࣥ⣔࡟㛵ࢃࡿᅉᏊࡀಟ㣭ࡋ࡚࠸ࡿࡇ࡜ࡀุ᫂ࡋ
࣭ CBSM2018 2018.10.6 ⚄ዉᕝ┴㙊಴࡚ࡁࡓࠋ௒ᚋࡣື≀ᐇ㦂࡟࡚ࠊ≉ᐃࡢศᏊࢆྠᐃࡋヲ⣽࡞ゎ࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍ 2018.11.29 ⚄ዉᕝ┴ᶓ὾ᕷᯒࢆ㐍ࡵࡿணᐃ࡛࠶ࡿࠋ࣭ ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘ 2018.12.14 ᮾி ➼࣭ 5-FUࡢ⾑୰ ᐃ࢟ࢵࢺ࡟㛵ࡋ࡚ࡣࠊヨసရࡀ᏶ᡂࡋࡓࡓࡵࠊ
࣭ European Academy of Allergy and Clinical Immunology᮶ᖺᗘࡣࠊࣄࢺࢧࣥࣉࣝࢆ⏝࠸ࡓ᳨ᐃࢆ⾜࠸ࠊ௻ᴗ࡜ࡢ㐃ᦠ
(EAACI), 2018.5. 26㹼5. 30, Munich, Germany.
࡟࡚〇ရ໬࡟ྥࡅࡓྲྀࡾ⤌ࡳࢆ⾜࠺ࠋ࣭ ࠕᮾிࣂ࢖࣐࣮࣮࢜࢝࢖ࣀ࣮࣋ࢩࣙࣥᢏ⾡◊✲⤌ྜ(3) ᅜෆእࡢ◊✲≧ἣ
㸦TOBIRA㸧ࠖࡢᢏ⾡⤌ྜࡢᇶ┙࡟ࡉࡽ࡟⏘Ꮫ་㐃ᦠࢆⓎᒎྛศ㔝࡜ࡶࠊᅜෆࠊᅜእࡢඛᑟⓗ࡞ᇶ♏◊✲ࠊ࠾ࡼࡧᐇ⏝ࡉࡏࠊከᦶᆅ༊࡟࠶ࡿ㒔❧⑓㝔⩌࡜ࡢᶫΏࡋ◊✲ࡢⓎᒎ࡟ࡘ໬◊✲ࢆ᥎㐍ࡋ࡚࠸ࡿࠋ
࡞ࡆࡿࠋ௒ᚋࡣࠊከᦶ⥲ྜࠊከᦶᑠඣࠊ㥖㎸⑓㝔➼ࢆ୰ᚰ࡟࠙ ᩍ ⫱ ά ື ࠚ Ⱚ ᓮ ኴ 㸸 㡑 ᅜ ᘏ ୡ ኱ Ꮫ ࣭ ᐈ ဨ ᩍ ᤵ 㸦  ᖺ
5-FU࢟ࢵࢺࢆ⏝࠸ࡓ⮫ᗋヨ㦂ࡸࠊITࠊࣟ࣎ࢸ࢕ࢡࢫᑟධ࡟㛵㹼㸧ࠊග⏘ᴗ๰ᡂ኱Ꮫ㝔኱Ꮫ࣭ᐈဨᩍᤵ㸦ᖺ㹼㸧ࠊཬࡧࡋ࡚ඹྠ◊✲ࢆ⾜࠼ࡿయไࢆᵓ⠏ࡍࡿணᐃ࡛࠶ࡿࠋ
୕㔜኱Ꮫࡢ≉ูㅮ⩏࣭ 㧗⑓ཎᛶ࢖ࣥࣇ࢚ࣝࣥࢨࡢ᪂つ౵ධ⤒㊰ࡢྠᐃࢆ㐍ࡵࡿࠋ(1)

ᴫせᮏ◊✲ࡣࠊ⒴ࠊឤᰁ⑕࡞࡝ࡢ⑌ᝈ࡟ࡘ࠸࡚ࠊ㒔❧࣭බ♫⑓㝔ࢆྵࡴᅜෆእࡢ⑓㝔ࠊ኱Ꮫࠊ◊✲ᡤࠊ௻ᴗ࡜ࡢඹྠ◊✲ࢆ
㏻ࡋ࡚ࠊ᪂つデ᩿ἲ࣭἞⒪ἲ㛤Ⓨࢆᇶᮏ࡟࠾࠸ࡓᇶ♏࣭⮫ᗋ◊✲࠾ࡼࡧࠊࡇࢀࡽࡢᡂᯝࢆ㒔Ẹࡢ་⒪࣭⚟♴࡟㑏ඖࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ◊✲ࢸ࣮࣐࡜ࡋ࡚ࠊ
1. ⒴໬ࡢᶵᗎゎ᫂㸸ప㓟⣲ࢫࢺࣞࢫࡸ⣽⬊⼥ྜࢆ௓ࡋࡓ᪂
つไᚚᶵᵓࡢゎ᫂࡜๰⸆
2. 㧗⑓ཎᛶ࢖ࣥࣇ࢚ࣝࣥࢨࡢ⑓ែゎ᫂࡜๰⸆
3. デ᩿ἲ㛤Ⓨ㸸㧗㏿㑇ఏᏊቑᖜ⿦⨨ࡸ࢖࣒ࣀࢡ࣐ࣟࢺ➼ࡢ
㛤Ⓨ
4. TOBIRA ࢆ௓ࡋࡓ⏘Ꮫ㐃ᦠࡢ᥎㐍࡟ࡼࡿᶫΏࡋ◊✲ࠊ㥖㎸⑓㝔➼ࡢࣂ࢖࢜ࣂࣥࢡ

୺࡞◊✲ᡂᯝ

－ 15 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ✲       ᡂ
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E

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(1) ᡂᯝࡢᴫせձ ALS ࡢⓎ⑕ᶵᵓ࡟ࡘ࠸࡚
࣭ C9orf72㑇ఏᏊ࡟Ꮡᅾࡍࡿ6ሷᇶࡢࣜࣆ࣮ࢺ㓄ิࡀᐙ᪘ᛶࡢFTLD࠾ࡼࡧALS࡟࠾࠸࡚ࡶࡗ࡜ࡶከ࠸㑇ఏᏊኚ␗࡜ࡋ࡚ྠᐃࡉࢀࡓࡀࠊኚ␗
ࡀ⑓Ẽࢆ࠾ࡇࡍ࣓࢝ࢽࢬ࣒ࠊTDP-43จ㞟࡜ࡢ㛵ಀࡣ୙࡛᫂࠶ࡗࡓࠋ
⚾㐩ࡣࠊC9orf72཯᚟㓄ิ࡟ࡼࡗ࡚⏘⏕ࡉࢀࡿࢪ࣌ࣉࢳࢻࣜࣆ࣮ࢺ(DPRs)࡜TDP-43ࢆᇵ㣴⣽⬊࡟Ⓨ⌧ࡉࡏࠊࡑࡢ㛵ಀࢆㄪ࡭ࡓ⤖ᯝࠊ
GFP-GAࢆⓎ⌧ࡉࡏࡓ⣽⬊࡟࠾࠸࡚ࡣࠊpoly-GAࢱࣥࣃࢡ㉁ࡢจ㞟ࡀほᐹࡉࢀࠊࡑࢀ࡟క࠸ෆᅾᛶTDP-43ཬࡧእ᮶ᛶTDP-43ࡀ⣽⬊ෆ࡛จ㞟ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋࡇࡢ⤖ᯝࡣC9orf72ࡢኚ␗࡟ࡼࡗ࡚poly-GA࡞࡝ࡢ␗ᖖࢱࣥࣃࢡ㉁ࡀ⏘⏕ࡉࢀࠊpoly-GA࡞࡝ࡀTDP-43ࡢ⵳✚ࢆㄏᑟࡍࡿࡇ࡜࡟ࡼࡗ࡚⚄⤒ኚᛶࡀ㉳ࡇࡿࡇ࡜ࢆ♧၀ࡍࡿࠋղ Șࢩࢾࢡࣞ࢖ࣥࡢ⵳✚ᶵᵓ࡟ࡘ࠸࡚࣭ ࣃ࣮࢟ࣥࢯࣥ⑓ࡸࣞࣅ࣮ᑠయᆺㄆ▱⑕࡟࠾࠸࡚Ș-ࢩࢾࢡࣞ࢖ࣥࡀ⚄⤒⣽⬊࡟⵳✚ࡍࡿࡇ࡜ࡀⓎ⑕ࠊ㐍⾜ࡢཎᅉ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡀࠊ᭱
ึࡢจ㞟ࡀ࡝ࡢࡼ࠺࡟ᙧᡂࡍࡿ࠿ࡣ᫂ࡽ࠿࡛ࡣ࡞࠸ࠋࡑࡇ࡛᩿∦໬ࡀȘࢩࢾࢡࣞ࢖ࣥࡢจ㞟ࡸఏ᧛࡬ࡢᙳ㡪࡟ࡘ࠸࡚ᵝࠎ࡞᩿∦໬ࢱࣥ
ࣃࢡ㉁ࢆ⏝࠸࡚จ㞟ᐇ㦂ࢆ⾜࠸ࠊᇵ㣴⣽⬊࡜㔝⏕ᆺ࣐࢘ࢫࡢ⬻࡬ࡢ᥋✀ᐇ㦂ࢆ⾜ࡗ᳨࡚ウࡋࡓࠋࡑࡢ⤖ᯝࠊ᩿∦໬࡟ࡼࡗ࡚άᛶࡸᵓ㐀ࡀ኱ࡁࡃ␗࡞ࡿจ㞟యࡀᙧᡂࡉࢀࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋճ ␗ᖖᆺȘࢩࢾࢡࣞ࢖ࣥࡢࣉࣜ࢜ࣥᵝάᛶ໬࡟ࡘ࠸࡚࣭ Șࢩࢾࢡࣞ࢖ࣥࡢ␗ᖖࡣࣞࣅ࣮ᑠయᆺㄆ▱⑕ࡔࡅ࡛࡞ࡃࠊከ⣔⤫ⴎ⦰⑕(MSA)࡟ࡶࡳࡽࢀࠊࡑࡢ⑓ែࡣ኱ࡁࡃ␗࡞ࡿࠋࡑࡇ࡛ᝈ⪅⬻࠿ࡽᢳฟࡋࡓ⑓ཎᛶȘ-ࢩࢾࢡࣞ࢖ࣥ࡟ࡘ࠸࡚ࠊࣉࣜ࢜ࣥᵝάᛶࢆヲ⣽࡟ㄪ࡭ࡓࠋࡑࡢ⤖ᯝࠊMSAࡢᝈ⪅⬻࡟⵳✚ࡍࡿ␗ᖖᆺȘࢩࢾࢡࣞ࢖
ࣥࡢࣉࣜ࢜ࣥᵝάᛶࡣࣞࣅ࣮ᑠయᆺㄆ▱⑕ࡢࡶࡢࢆ኱ࡁࡃ␗࡞ࡿࡇ
࡜ࡀ♧ࡉࢀࡓࠋ⑌ᝈ࡟ࡼࡗ࡚␗ᖖᆺࢱࣥࣃࢡ㉁ࡢᵓ㐀ࡀ␗࡞ࡿྍ⬟ᛶࢆ♧၀ࡍࡿࠋ

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(2)

◊✲⪅ྡ
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ஂỌ┾ᕷ
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◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

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(1)

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾㄆ▱⑕ࡢⓎ⑕࡜㐍⾜ᶵᗎࡢゎ᫂㸭ㄆ▱⑕ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㛗㇂ᕝᡂே㸧(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ᅜෆእࡢ◊✲≧ἣ࣭௒ᚋࡶᘬࡁ⥆ࡁࠊᵝࠎ࡞ㄆ▱⑕ࠊ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែᙧᡂ࡜㐍⾜࡟ᮏࣉࣟࢪ࢙ࢡࢺࡢ୺せࢸ࣮࣐࡛࠶ࡿ␗ᖖࢱࣥࣃࢡ㉁ࡢఏ᧛࡟
㛵ࢃࡿࢱ࢘ࠊĮࢩࢾࢡࣞ࢖ࣥࠊTDP-43ࡢ⵳✚ࠊ␗ᖖ⑓⌮࡟ࡘ࠸࡚ヲ㛵ࡍࡿ◊✲ࡣࠊୡ⏺ⓗ࡟ࡶ኱ࡁ࡞ὀ┠ࢆ㞟ࡵ࡚࠾ࡾ⚄⤒ኚᛶ⑌⣽࡟᳨ウࡍࡿ࡜ඹ࡟ࠊᐇ㝿ࡢ⑓ែ࡟㏆࠸ヨ㦂⟶ࠊ⣽⬊ࠊື≀ࣔࢹࣝᝈࠊㄆ▱⑕◊✲࡟࠾ࡅࡿ኱ࡁ࡞₻ὶ࡜࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ⣽⬊ࡢᵓ⠏ࡋࠊㄆ▱⑕⑌ᝈࡢ἞⒪ἲࠊ἞⒪⸆ࡢ㛤Ⓨ࡟㈉⊩ࡍࡿ◊✲ࢆ㐍ෆࡢ␗ᖖࢱࣥࣃࢡ㉁ࡢఏ᧛ไᚚࡣ἞⒪ࢆ⪃࠼ࡿୖ࡛ࡶ㔜せ࡛ࡵ࡚࠸ࡁࡓ࠸ࠋ࠶ࡾ〇⸆௻ᴗ➼ࡶᙉ࠸㛵ᚰࢆᐤࡏ࡚࠸ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A,
Hirai S, Okado, H., Hasegawa M. C9ORF72 dipeptide repeat
poly-GA inclusions promote: intracellular aggregation ofphosphorylated TDP-43. Hum Mol Genet, 2018 May 10. doi:
10.1093/hmg/ddy174.
࣭ Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, andHasegawa M. The effect of truncation on prion-like properties
RI Į-synuclein. J Biol Chem 293:13910-13920, 2018. doi:
10.1074/jbc. RA118.001862.
࣭ Tarutani, A, Arai T Murayama, S., Hisanaga, S.I., Hasegawa,
M. Potent prion-like behaviors of pathogenic Ș-synuclein andevaluation of inactivation methods. Acta Neuropathol
Commun 6: 29, 2018. ࡯࠿(1)ᴫせ㉸㧗㱋໬♫఍ࡢ㐍ᒎ࡟క࠸ࠊㄆ▱⑕ࡣ㤳㒔ᮾி࡟࠾࠸࡚ࡶ
኱ࡁ࡞♫఍ၥ㢟࡜࡞ࡗ࡚࠾ࡾࠊࡑࡢཎᅉゎ᫂࡜἞⒪ἲࡢ㛤Ⓨࡀᛴົ࡛࠶ࡿࠋㄆ▱⑕ࡣࡑࡢ⑕≧ࡸ⑓ែ࡟ࡼࡾศ㢮ࡉࢀ࡚࠸ࡿࡀࠊ⑕≧ࢆᘬࡁ㉳ࡇࡍཎᅉࢱࣥࣃࢡ㉁ࡢ✀㢮㸦ࢱ࢘ࠊĮࢩࢾࢡࣞ࢖ࣥࠊTDP-43࡞࡝㸧࡟ࡼࡗ࡚ศ㢮ࡉࢀࡿࠋཎᅉࢱࣥࣃ
ࢡ㉁ࡢ␗ᖖ⑓ኚࡢᗈࡀࡾࡀ⑓ែ㐍⾜࡜῝ࡃ㛵ࢃࡗ࡚࠾ࡾࠊࡇ
ࢀࡽࡢ␗ᖖ⑓ኚࡢᙧᡂᶵᗎࡸᗈࡀࡾࢆᢚ࠼ࡿࡼ࠺࡞἞⒪ἲࢆ
㛤Ⓨࡍࡿࡓࡵࡢ◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࡲࡓࠊ㒔❧⑓㝔➼࡜ࡢ㐃ᦠ࡟ࡼࡾᝈ⪅⬻ヨᩱࡢヲࡋ࠸⏕໬Ꮫゎᯒࢆ⾜࠸ࠊࡑࡢ⤖ᯝࢆ⮫ᗋࡢ⌧ሙ࡟㑏ඖࡍࡿ࡜࡜ࡶ࡟ࠊ⸆ຠホ౯ࡢࡓࡵࡢᐇ㦂ࣔࢹࣝࡢస〇࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

୺࡞◊✲ᡂᯝ

－ 16 －

ᴫせᏛ⩦࣭グ᠈ࡢ࣓࢝ࢽࢬ࣒ࢆ⣽⬊࣭ᅇ㊰ࣞ࣋ࣝ࠿ࡽ㑇ఏᏊ࣭ศᏊࣞ࣋ࣝ࡟࠿ࡅ࡚ゎᯒࡍࡿࠋ᫂ࡽ࠿࡟࡞ࡗࡓᏛ⩦グ᠈ࡢ࣓࢝ࢽࢬ࣒࡟↷ࡽࡋࠊຍ㱋ࡸ⑌ᝈ࡞࡝࡟ࡼࡾ㉳ࡇࡿㄆ▱㞀ᐖࡢཎᅉࢆ᫂ࡽ࠿࡟ࡋࠊண
㜵࣭ᨵၿ࣭἞⒪ࡢ᪉ἲㄽࡢ☜❧࡟㈉⊩ࡍࡿࠋ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡMatsuno M et al, iScience 15, 55-65 (2019).
Ueno K et al, bioRxiv.(2018)
Miyashita T et al, Cell Rep 25, 2716-2728.e3.
Sato S et al, J Physiol. 596, 2447-2461 (2018)(4)ᅜෆእࡢ◊✲≧ἣin vivo࢖࣓࣮ࢪࣥࢢࢆྲྀࡾධࢀࡓᏛ⩦グ᠈ࡢᒁᡤᅇ㊰ゎᯒࡀ㐍ࢇ࡛࠸ࡿࠋ୺࡜ࡋ࡚JFRCࡀᥦ౪ࡍࡿᅇ㊰≉␗ⓗ࡞GAL4⣔⤫ࢆ฼⏝ࡍࡿࡇ࡜࡛ࠊ࢟ࣀࢥయ࡜࢟ࣀࢥయฟຊ⣽⬊ࠊࢻ࣮ࣃ࣑ࣥ⣽⬊࡟ࡼࡿ཯ᅇᅇ㊰࡞࡝ࡢྠᐃ࡜ᶵ⬟ゎᯒࡀ㐍ࢇ࡛࠸
ࡿࠋ

࣭
࣭
࣭
࣭

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼

(3)

(1)
(2)

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E

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(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ᚋࢩࢼࣉࢫ⣽⬊ㄏᑟᛶࢻ࣮ࣃ࣑ࣥᨺฟᶵᵓࡢࡼࡾヲ⣽࡞ศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋ࡚࠸ࡃࠋ࣭ ᪂つࢻ࣮ࣃ࣑ࣥࢭࣥࢧ࣮ࢆ⏝࠸ࡓin vivo࢖࣓࣮ࢪࣥࢢ࡜⾜ື㑇ఏᏛⓗᡭἲࢆ⤌ࡳྜࢃࡏࠊ㐃ྜᏛ⩦㐣⛬࡛ࡢࢻ࣮ࣃ࣑ࣥᨺ
ฟࢱ࢖࣑ࣥࢢ࡜⾜ືᏛⓗ▱ぢ࡜ࡢ┦㛵ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ࣭ ຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖ࡜ࠊ㛗ᮇグ᠈Ꮫ⩦࡟ࡼࡿࢻ࣮ࣃ࣑ࣥసື
ᛶ⚄⤒ࡢᶵ⬟㞀ᐖ࡜ࡢ㛵ࢃࡾࢆ㑇ఏᏛⓗ࢖࣓࣮ࢪࣥࢢゎᯒ࡟ࡼࡾヲ⣽࡟ゎᯒࡍࡿࠋᡂᯝࡢᴫせ࣭ 㛗ᮇグ᠈Ꮫ⩦࡟ࡼࡾࢢࣜ࢔⣽⬊࡛㌿෗ᅉᏊRepo౫Ꮡᛶ࡟ࢢࣝ
ࢱ࣑ࣥ㓟㍺㏦యࡢⓎ⌧ࡀୖ᪼ࡍࡿࡇ࡜࡛ࠊࢢࣝࢱ࣑ࣥ㓟ࢩࢢࢼࣝࡢ㐣άືࢆᢚไࡍࡿᚲせࡀ࠶ࡿࡇ࡜ࠊࡇࡢ㐣⛬ࡀຍ㱋య࡛㞀ᐖࡉࢀࡿࡇ࡜ࡀࠊຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖࡢཎᅉ࡜࡞ࡿࡇ࡜
ࢆゎ᫂ࡋࠊㄽᩥࢆⓎ⾲ࡋࡓ㸦ᯇ㔝ࡽࠊiScience 2019㸧࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࢟ࣀࢥయ࡛ໝ࠸᎘ᝏグ᠈᝟ሗࢆࢥ࣮ࢻࡍࡿ
グ᠈⑞㊧⣽⬊ࡢᙧᡂࢆぢฟࡋࠊࡑࡢᙧᡂ࡟㌿෗ᅉᏊCREB࡜ࡑࡢ㌿෗⏘≀c-Fos࡜ࡢ㛫࡛㌿෗ࢧ࢖ࢡࣝࡀᙧᡂࡉࢀࡿࡇ࡜ࡀᚲせ࡞ࡇ࡜ࠊ㌿෗ࢧ࢖ࢡࣝࡢᙧᡂ࡟ࡣ㛫ࢆ✵ࡅࡓ⧞ࡾ㏉ࡋᏛ⩦ࡢ㛫࡛άᛶ໬ࡉࢀࡿERKࡀᚲ㡲࡛࠶ࡿࡇ࡜ࡀศ࠿ࡗࡓ㸦ᐑ
ୗࡽCell Rep 2018㸧ࠋ࣭ ༢㞳ᇵ㣴⬻ࡢ࢖࣓࣮ࢪࣥࢢゎᯒ࠿ࡽࠊྠᮇධຊࢆཷࡅࡓࢩࢼ
ࣉࢫᚋ⣽⬊࡟ࡼࡿࠊ୍㓟໬Ⅳ⣲ࢆ㏫ගᛶࢩࢢࢼࣝ࡜ࡋࡓࠊࢻ
࣮ࣃ࣑ࣥ㛤ཱྀᨺฟㄏᑟࡀࠊ့ங㢮࡟ࡶᙜ࡚ࡣࡲࡿ࠿ࠊ࣐࢘ࢫ
ᡥ᱈యࢆࣔࢹࣝ࡟㟁Ẽ⏕⌮Ꮫⓗ᳨ドࢆ㐍ࡵࡓ㸦㕥ᮌࠊୖ㔝ࡽ㸧ࠋࡉࡽ࡟᪂つࢻ࣮ࣃ࣑ࣥࢭࣥࢧ࣮ࢆ⏝࠸࡚ࠊໝ࠸᎘ᝏᏛ
⩦ࠥグ᠈ಖᣢࠥ᝿㉳ࡑࢀࡒࢀࡢ㐣⛬࡛ࡢࢻ࣮ࣃ࣑ࣥᨺฟ⬗యࢆㄪ࡭ࠊ࢟ࣀࢥయࡢ㒊఩≉␗ⓗ࡞ᨺฟ࡜ࡢ┦㛵ࢆㄪ࡭ࡓࠋ
(1)

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(2) ◊✲⪅ྡ
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◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
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㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸㰺⸨ ᐇ㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ

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◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ⬨㧊࡬ࡢேᕤ⚄⤒᥋⥆ࡣすᮧࡀࣃ࢖࢜ࢽ࢔࡛࠶ࡾࠊ⚄⤒ᶵᗎゎ᫂ࢆ┠ᣦࡋࡓ◊✲࡛ࡶࠊ⮫ᗋ◊✲࡟࠾࠸࡚ࡶୡ⏺ࢆඛᑟࡋ࡚࠸ࡿࠋࡲࡓࠊື≀ࣔࢹࣝࢆ⏝࠸ࡓពḧ࡟㛵ࢃࡿഃᆘ᰾ࡀ
⬨㧊ᦆയᚋ࡟ᶵ⬟ᅇ᚟࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ◊✲ࡶࠊすᮧࡀぢฟࡋࡓࡶࡢ࡛࠶ࡾࠊࡑࢀࢆࣄࢺ࡬ᒎ㛤ࡋ࡚࠸ࡿࠋࡇࡢ
ᡂᯝࡣ⢭⚄⛉㡿ᇦ࡜ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ㡿ᇦࢆ⧅ࡆࡿࡶࡢ࡜
࡞ࡿ࡜⪃࠼ࡽࢀࠊ௒ᚋ኱ࡁ࡞ὀ┠ࡀ㞟ࡲࡿࡇ࡜ࡀᮇᚅࡉࢀ
ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Frontiers in Neuroanatomy
࣭ Journal of Comparative Neurology࣭ ィ ࡜᪥ᮏ⚄⤒⛉ᏛᏛ఍࣭ ไᚚࠊ⮫ᗋࣜࣁࣅࣜࢸ࣮ࢩ࣭ࣙࣥ ⬨㧊እ⛉Ꮫ఍࣭ Society for Neuroscience࣭ Spinal Research Conference ➼

(1)

࣭

࣭
࣭
࣭
࣭
࣭
࣭

(2)

ᴫせ
(1)
⸆≀ࠊ⣽⬊⛣᳜ࠊBrain computer Interface(BCI)ᢏ⾡࡟ࡼࡿேᕤ⚄⤒᥋⥆ࠊ㑇ఏᏊᑟධࠊ᝟ືࡢ᧯సࡢ⤌ࡳྜࢃࡏ࡟ࡼࡾࠊ
ᶵ⬟ᅇ᚟࣭෌ᘓຠᯝࢆ᭱኱㝈࡟ᘬࡁฟࡍࣁ࢖ࣈࣜࢵࢻ἞⒪ἲࢆື≀ࣔࢹࣝ࡟࡚㛤Ⓨࡋࠊࡇࢀࢆࣄࢺࡢ⬻࣭⬨㧊ᦆയᝈ⪅࡛ࡑࡢ᭷ຠᛶࢆ⮫ᗋ◊✲࡟࡚ド᫂ࡍࡿࠋࡇࢀ࡟ࡼࡾ⬻⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟࣭෌ᘓࢆ᭱኱໬ࡍࡿ㠉᪂ⓗ࡞἞⒪ἲࢆ☜❧ࡋࠊࡑࡢᶵ⬟ᅇ᚟ᶵᗎࡢゎ᫂ࢆࡍࡿࠋ

୺࡞◊✲ᡂᯝ✲       ᡂ

E

ᯝ


௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ேᕤ⚄⤒᥋⥆ࡢ௓ධຠᯝࡢ⦪᩿ⓗㄪᰝேᕤ⚄⤒᥋⥆ࡀ᭷ຠ࡞ᝈ⪅ࡢุᐃ࣭Ᏻ඲ᛶࡢ᳨ドᶵ⬟ᅇ᚟ࡢᚰ⌮ᣦᶆࡢ᥈⣴⤒㊰㑅ᢥ⚄⤒άືಁ㐍࣭ᢚไἲࡢ㛤Ⓨഃᆘ᰾άືไᚚ࡟ࡼࡿᶵ⬟ᅇ᚟ἲࡢ㛤Ⓨ㐠ືไᚚᶵᵓ࡟ᑐࡍࡿ⚄⤒ఏ㐩≀㉁ࡢᙳ㡪ࡢ᳨ウࣄࢺ⬨㧊ᵓ㐀MRI࣭ᶵ⬟ⓗMRI᧜ᙳἲࡢ㛤Ⓨᡂᯝࡢᴫせ࣭⬨㧊ᦆയࢧࣝࡢከ㡿ᇦ⓶㉁άືゎᯒ࠿ࡽࠊᶵ⬟ᅇ᚟࡟ࡣᕥྑࡢ⓶㉁㡿ᇦ㛫ࡢάື㐃㛵ࡼࡾࡶࠊ཯ᑐഃ㐠ື㛵㐃㡿ᇦ࠿ࡽ➽⫗ࢆᨭ㓄ࡋ࡚࠸ࡿ୍ḟ㐠ື㔝άືࡢάᛶ໬ࡀ
㛵୚ࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ⬨㧊ᦆയࢧࣝࡢ⬻ᶵ⬟࢖࣓࣮ࢪࣥࢢ࡜⸆⌮ᐇ㦂ࡢ⤖ᯝ࠿ࡽᡭࡢᕦ⦓ᛶࡢᶵ
⬟ᅇ᚟࡟ពḧ୰ᯡ࡛࠶ࡿഃᆘ᰾ࡀᚲ㡲࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ
࠿࡟࡞ࡗࡓࠋ
࣭ேᕤ⚄⤒᥋⥆ࡢከ᪋タ⮫ᗋ◊✲ 㸱᪋タ࡛⬨㧊ᦆയ⪅࡟ᑐࡍࡿேᕤ⚄⤒᥋⥆ࡢ⮫ᗋ◊✲ࢆ㸳ྡ࡛⥅⥆ⓗ࡟ᐇ᪋ࡋࠊࡍ࡭࡚ࡢᝈ⪅ேᕤ⚄⤒᥋⥆࡟ࡼࡾ㝶ពṌ⾜ᶵ⬟ࡀᨵၿࡋࡓࠋ⣽⬊⛣᳜࡜ேᕤ⚄⤒᥋⥆࡜ࡢࣁ࢖ࣈࣜࢵࢻ἞⒪ࡢຠᯝࢆ᳨ドࡍࡿ⮫ᗋ◊✲ࢆ⬨㧊ᦆയᝈ⪅㸦㸯౛┠㸧࡛㛤ጞࡋࠊࣁ࢖ࣈࣜࢵࢻ἞⒪ࡢຠᯝࡀほࡽࢀࠊṌ⾜㏿ᗘࡀ
㏿ࡃ࡞ࡗࡓࠋᘏ࡭㸯㸮㸵ᅇࡢ㠀౵くⓗேᕤ⚄⤒᥋⥆ࡢᐇ㦂ࢆ⾜࠸ࠊᚠ⎔ჾ⣔࣭⮬ᚊ⚄⤒⣔࡟㔜኱࡞๪స⏝ࡀ⏕ࡌࡿᜍࢀࡀ࡞࠸ࡇ࡜ࢆ☜ㄆࡋࡓࠋ࣭ሗ㓘࡟ࡼࡿពḧࡢ᧯స࡜㐠ືᡂᯝࡢ㛵ಀ࡟ࡘ࠸࡚ࠊࣄ
ࢺࡢfMRI࡛ࡢ◊✲࡜ࢧ࡛ࣝࡢゎ๗Ꮫⓗ◊✲࠿ࡽᚓࡽࢀࡓ
⤖ᯝ࠿ࡽࠊሗ㓘᧯సэ๓㢌๓㔝э⿕⵹㔝/㯮㉁э㐠ື㔝э⬨㧊ࢆ⧅ࡄ⤒㊰ࡀࠊពḧࡀ㌟య㐠ືࢆไᚚࡍࡿ⚄⤒ᇶ┙࡛࠶ࡿࡇ࡜ࢆ♧ࡍࡇ࡜ࡀ࡛ࡁࡓࠋ

◊


E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦༠ຊ◊✲ဨ㸧༡㒊 ⠜㸦⏕⌮Ꮫ◊✲ᡤ㸧▱ぢ⪽⨾㸦⏕⌮Ꮫ◊✲ᡤ㸧Ⳣཎ ⩧㸦⏕⌮Ꮫ◊✲ᡤ㸧㸦ᐈဨ◊✲ဨ㸧ᫍ ⱥྖ㸦ᮌ᭦ὠ⑓㝔㸧Ἑྜ୍Ṋ㸦᪥ᮏ኱Ꮫ㸧(2) ◊✲⪅ྡ
すᮧᖾ⏨
୰ᒣ⩏ஂ
⏣ῧṓᶞ
▼⏣⿱᫛
ᶓᒣ ಟ
㕥ᮌ㏔ㄹ

(1)

◊✲ᮇ㛫
2017ᖺ4᭶㹼2020ᖺ3᭶
㸦3ᖺ㛫㸧

A

⬻⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟ᶵᗎゎ᫂࡜ᶵ⬟෌ᘓἲࡢ㛤Ⓨ㸭⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸すᮧᖾ⏨㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 18 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼(3)ᅜෆእࡢ◊✲≧ἣ࣑ࢡࣟࢢࣜ࢔ࡢ◊✲ࡣ㏆ᖺ㛵ᚰࡀ㧗ࡲࡗ࡚࠸ࡿࡀࠊ⏕ᚋࡢ⬻࡟࠾ࡅࡿ࣑ࢡࣟࢢࣜ࢔ࡢືែ࡟ࡘ࠸࡚ࡣᅜෆእࢆ㏻ࡌ࡚◊✲ࡣ㐍ࢇ࡛࠸࡞࠸ࠋࡲࡓᛴᛶ⬻⑕ࠊከⓎᛶ◳໬⑕➼ࡢᑠඣࡢච␿ᛶ⚄⤒⑌ᝈ࡟ࡘ࠸࡚ࡶࠊᡂே㡿ᇦ࡜ẚ㍑ࡋ࡚◊✲ࡣ❧ࡕ㐜ࢀ࡚࠸ࡿࠋ

ㄽᩥᥖ㍕
࣭ Clin Exp Neuroimmunol, Epilepsy Seizure, Case Rep Pediatr,
Brain Dev
≉ู࣭ᩍ⫱ㅮ₇
࣭ Asian & Oceanian Congress of Neurology
࣭ Annual & Scientific Meeting of Taiwan Child Neurology
Society࣭ ᪥ᮏᑠඣ⚄⤒Ꮫ఍࣭ ᪥ᮏ࡚ࢇ࠿ࢇᏛ఍࣭ ᪥ᮏᑠඣᩆᛴ་Ꮫ఍

(2)

(1)

ᴫせ
ձ ᇶ♏◊✲
1) ࣑ࢡࣟࢢࣜ࢔ࡢ෌ศᕸࣔࢹࣝࢆ⏝࠸ࡓࢢࣜ࢔⣽⬊ࡢᩘⓗᜏᖖᛶ⥔ᣢᶵᵓࡢゎ᫂, 2) P2Y12ࣉࣜࣥཷᐜయࡀ࣑ࢡࣟࢢ
ࣜ࢔ࡢᶵ⬟࡟ཬࡰࡍᙳ㡪, 3) ᢠ࡚ࢇ࠿ࢇ⸆ࡀ࣑ࢡࣟࢢࣜ࢔ࡢ
ᙧ㉁࡟୚࠼ࡿᙳ㡪4) ࢔ࢫࢺࣟࢧ࢖ࢺ࡟ࡼࡿࢢࣝࢱ࣑ࣥ㓟ࢫ࢝࣋ࣥࢪࡢไᚚղ ⮫ᗋ◊✲
5) ᛴᛶ⬻⅖࣭⬻⑕࡟࠾ࡅࡿ᪂つࣂ࢖࣐࣮࣮࢜࢝ࡢ᥈⣴࡜⑓ែゎ᫂, 6) ⅖⑕ᛶ⚄⤒⑌ᝈ࡜ᢠ⚄⤒ᢠయ୺࡞◊✲ᡂᯝ✲       ᡂ

E

ᯝ


࣭

࣭

(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ᇶ♏◊✲࡛ࡣ࣑ࢡࣟࢢࣜ࢔ࡢ෌ศᕸᶵᵓ࡟㛵ࡍࡿㄽᩥ໬࡟
ຍ࠼࡚ࠊ࢔ࢫࢺࣟࢧ࢖ࢺ◊✲࡜࣑ࢡࣟࢢࣜ࢔ࡢin vivo◊✲ࢆຍ㏿ࡍࡿࠋ
⮫ᗋ◊✲࡛ࡣࣂ࢖࣐࣮࣮࣭࢜࢝⮬ᕫᢠయ࡜⮫ᗋᡤぢ࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡋࠊࡉࡽ࡟᪂ࡓ࡞ᢠ⚄⤒ᢠయࡢ᥈⣴ࢆヨࡳࡿࠋղ ⮫ᗋ◊✲
5) ㎶⦕⣔⬻⅖ࡣ㧊ᾮ⣽⬊ᩘቑຍࡢ᭷↓࡟ࡼࡾ㧊ᾮ୰ࢧ࢖ࢺ࢝
࢖ࣥࣉࣟࣇ࢓࢖ࣝࡀ␗࡞ࡾ㸪」ᩘࡢள⩌ࢆྵࡴࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ6) ᢠMOGᢠయࡀ⿵య౫Ꮡᛶ࡟MOGⓎ⌧⣽⬊ࢆയᐖࡍࡿࡇ࡜ࢆ
ド᫂ࡋࡓࠋ(1) ᡂᯝࡢᴫせձ ᇶ♏◊✲
1) in vitro࡟࠾ࡅࡿ࣑ࢡࣟࢢࣜ࢔෌ศᕸࡢᐇ㦂⣔ࢆ⏝࠸࡚࣑ࢡࣟࢢࣜ࢔ࡢ⏕Ꮡ࡜ศ⿣ቑṪ࡟㛵ࢃࡿヲ⣽࡞ศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡓࠋ2) P2Y12ࣉࣜࣥ࡟ADPࡀ⤖ྜࡍࡿ࡜K+࢖࢜ࣥࡢὶฟࢆ௓ࡋ࡚
⅖⑕ᛶࢧ࢖ࢺ࢝࢖ࣥ⏘⏕㈇࡟ไᚚࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ3) ᢠ࡚ࢇ࠿ࢇ⸆ࣂࣝࣉࣟ㓟ࡀ࣑ࢡࣟࢢࣜ࢔ࡢࢧ࢖ࢺ࢝࢖ࣥ⏘⏕ࢆᢚไࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
4) ࢔ࢫࢺࣟࢧ࢖ࢺ࡟ࡼࡿࢢࣝࢱ࣑ࣥ㓟ྲྀࡾ㎸ࡳ⬟ࢆไᚚࡍࡿ⸆๣ࢆホ౯ࡍࡿࡓࡵ࡟in vitroࡢᐇ㦂⣔ࢆ☜❧ࡋࡓࠋ

A

◊


E

◊✲⪅ྡ

ῄᚨ኱Ꮫ
ᯘ 㞞ᬕᮾி኱ᏛⓎ㐩་⛉Ꮫ
ᫍ㔝 ឡ

⇃⏣⪽Ꮚ

ᮾி㒔❧⚄⤒⑓㝔⚄⤒ᑠඣ⛉ᮾி໭♫఍ಖ㝤⑓㝔ᑠඣ⛉ᐑ⏣⌮ⱥᮾி㒔❧ᗓ୰⒪⫱ࢭࣥࢱ࣮
ᑠඣ⛉
⚟Ỉ㐨㑻
⏣἟┤அ

⬻Ⓨ㐩࣭⚄⤒෌⏕◊✲ศ㔝
బஂ㛫ၨ
ᯇᒸ㈗Ꮚ
⚄ᒣ㑥Ꮚ
㕥ᮌᬛ඾
ᇼ㔝ᮅᏊ
す⏣⿱ဢ
᳃ᒣ๢ග
⸨⏣ᇶ㈨
ඵ㇂㟹ኵ
ከ⏣ᘯᏊ

(2)

2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊✲ᮇ㛫

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(1)Aࡇ࡝ࡶࡢ⬻࡟࠾ࡅࡿ⎔ቃ⥔ᣢᶵᵓࡢゎ᫂㸭ࡇ࡝ࡶࡢ⬻ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸బஂ㛫ၨ㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 19 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣୖグࡢ⑓ែࢆ◊✲ࡋ࡚࠸ࡿ◊✲ᐊࡣᅜෆእ࡟ᩘከࡃ࠶ࡿ
ࡀࠊศᏊ࣭⣽⬊࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡋࠊࡑࢀ࡟ᇶ࡙࠸࡚἞⒪⸆ࢆ᥈⣴ࡋ࡚࠸ࡿ◊✲ᐊࡣୡ⏺ⓗ࡟ࡶᩘ࠼ࡿ⛬࡛࠶ࡿࠋࡲࡓࠊ
ከࡃࡀୡ⏺ࢺࢵࣉࣞ࣋ࣝࡢ◊✲ᐊ࡛࠶ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ JoVE. 12;(136), 2018.
࣭ Sci Rep. 8(1):10132, 2018.
࣭ Elife. 7. pii: e34593, 2018.
࣭ Mol Biol Evol, 35:2928-2939, 2018.
࣭ Biochim Biophys Acta Mol Cell Res. 16. pii: S01674889(18)30093-4, 2018.
࣭ Gene. 642:343-353, 2018.
࣭ International Tuberous Sclerosis Complex Research Conference
2018 (2018.9.14)
࣭ ➨27ᅇᾏ㤿࡜㧗ḟ⬻ᶵ⬟Ꮫ఍ (2018.9.29,ᮾி)࣭ 61st Annual Meeting of the Japanese Society for
Neurochemistry. (2018.9.8, Kobe)࣭ 22nd Biennial Meeting of the International Society for
Developmental Neuroscience. (2018.5.22, Nara)(1)

ᴫせࠕࢩࢼࣉࢫࠖࡣ⚄⤒⣽⬊ྠኈࡢ᥋ྜ㒊࡛࠶ࡾࠊࢩࢼࣉࢫࡀ
ṇࡋࡃᙧᡂࡉࢀ࡞࠸࡜⬻ࡶṇᖖ࡟ᶵ⬟ࡋ࡞࠸ࠋᮏࣉࣟࢪ࢙ࢡ
ࢺ࡛ࡣࠊࢩࢼࣉࢫྍረᛶࡢ␗ᖖ㸦㞴἞࡚ࢇ࠿ࢇࡸ⢭⚄㐜⁫ࠊ⮬㛢⑕࡞࡝㸧ࢆᑐ㇟࡜ࡋࠊࡑࡢ⑓ែ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜࡟ࡼࡾ᭷ຠ࡞἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ✲       ᡂ

E

ᯝ


(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࣄࢺiPS⣽⬊࠿ࡽศ໬ࡉࡏࡓ㔝⏕ᆺ࡜TSC⣽⬊ࢆ⏝࠸࡚࢝ࣝࢩ࢘
࣒࢖࣓࣮ࢪࣥࢢࢆ⾜࠸ࠊ⚄⤒άື࡟┦㐪ࡀ࠶ࡿ࠿࡝࠺࠿ࢆ᳨ウࡍࡿࠋࡲࡓࠊ࣐࢘ࢫࡢグ᠈⑞㊧⣽⬊࡟ࢳࣕࢿࣝࣟࢻࣉࢩࣥࢆⓎ⌧ࡉࡏࠊග่⃭࡟ࡼࡾグ᠈ࡀ᝿㉳࡛ࡁࡿ࠿࡝࠺࠿ࢆ᳨ドࡍࡿࠋղ Rheb㜼ᐖ⸆ᢞ୚࡟ࡼࡿࠊTsc2+/-࣐࢘ࢫࡢᅇ㊰ືែࡢᅇ᚟
グ᠈࡟㛵ࢃࡿ⚄⤒⣽⬊ࢆྠᐃࡋࠊࡑࡢάືࡸࢩࢼࣉࢫᙧែࢆほᐹࡍࡿࡓࡵࠊάື౫Ꮡⓗ࡟EGFPࢆⓎ⌧ࡍࡿ࢔ࢹࣀ㝶క࢘࢖ࣝࢫ㸦AAV㸧ࢆ࣐࢘ࢫᾏ㤿ṑ≧ᅇ࡟ὀධࡋࡓࠋࡑࡋ࡚ࠊグ㖭ࡸ᝿㉳࡟కࡗ࡚άືࡍࡿࢽ࣮ࣗࣟࣥ㸦⑞㊧⣽⬊㸻࢚ࣥࢢ࣒ࣛ㸧ࢆᶆ㆑ࡋࠊ㔝⏕ᆺ࡜Tsc2+/-࣐࢘ࢫ㛫࡛ẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝࠊ㔝⏕ᆺ࡛ࡣ᝿㉳࡟కࡗ࡚グ᠈⑞㊧⣽⬊ࡀቑຍࡋࡓࡀࠊTsc2+/-࣐࢘ࢫ࡛ࡣ᭷
ព࡞ቑຍࡣぢࡽࢀ࡞࠿ࡗࡓࠋࡉࡽ࡟ࠊTsc2+/-࣐࢘ࢫ࡟Rheb㜼ᐖ⸆ࢆᢞ୚ࡍࡿ࡜ࠊグ᠈⑞㊧⣽⬊ࡀቑຍࡋࠊࡑࡢࢫࣃ࢖ࣥᐦᗘࡶቑ
ຍࡋࡓࠋࡍ࡞ࢃࡕࠊRheb㜼ᐖ⸆࡟ࡼࡗ࡚Tsc2+/-࣐࢘ࢫࡢグ᠈ࡀᅇ᚟ࡍࡿࡢࡣࠊࢩࢼࣉࢫࡀᅇ᚟ࡋࠊグ᠈ᅇ㊰ࡢືែࡀᨵၿࡍࡿࡓ
ࡵ࡜⪃࠼ࡽࢀࡓࠋᡂᯝࡢᴫせձ ࣄࢺTSC⚄⤒⣽⬊ࡢసᡂ࡜Rheb㜼ᐖ⸆ࡢຠᯝࣄࢺiPS⣽⬊㸦⌮◊ࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ࡼࡾධᡭ㸧ࡢTsc2㑇
ఏᏊ࡟ࠊCRISPR/Cas9ἲࢆ⏝࠸࡚ኚ␗ࢆᑟධࡋࠊࣄࢺTSC⣽⬊ࢆసᡂࡋࡓࠋࡑࢀࢆ⚄⤒⣽⬊࡬ศ໬ࡉࡏࠊࡑࡢᙧែࢆ㔝⏕ᆺ࡜ẚ㍑
ࡋࡓࠋࡑࡢ⤖ᯝࠊTsc2-/-ࢽ࣮ࣗࣟࣥࡣࠊ㔝⏕ᆺ࡟ẚ࡭࡚⣽⬊యࡀ኱ࡁࡃࠊ⣽⬊య࠿ࡽఙࡧࡿᶞ≧✺㉳ࡢᮏᩘࡶከ࠸ࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
ࡉࡽ࡟ࠊ㔝⏕ᆺ࡜Tsc2-/-ࢽ࣮ࣗࣟࣥࡢࣜࣥ㓟໬S6ࢆẚ㍑ࡋࡓ࡜
ࡇࢁࠊTsc2-/-ࢽ࣮࡛ࣗࣟࣥࡣࣜࣥ㓟໬ࡀஹ㐍ࡋ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡗ
ࡓࠋࡑࡋ࡚ࠊTsc2-/-⚄⤒⣽⬊ࢆRheb㜼ᐖ⸆࡛3᪥㛫ฎ⌮ࡋࡓ࡜ࡇ
ࢁࠊS6ࡢࣜࣥ㓟໬ࣞ࣋ࣝࡀ᭷ព࡟పୗࡋࡓࠋ
(1)

A

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E

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  㛫࣭  ◊✲  ⪅ྡ  ➼ᯇᮧ ₩㸦኱㜰ᕤ኱㸧ዟᮧᙲஂ㸦ឡ▱་኱㸧㸦㡰ኳᇽ኱㸧⏣୰⚽࿴㸦❧࿨㤋኱㸧➉ᐑᏕᏊ㸦ᮾிዪᏊ་኱㸧ᑠᯘᩄஅࠊᵽ㔝⯆ኵ᱇ᯘ⚽ኴ㑻㸦⚟ᒸ኱㸧ᚋ⸨⣧୍ࠊ⸨ཎᾈᶞࠊ
⸨஭ ⪽㸦ᒣᙧ኱㸧᪂஭ಙ㝯㸦⚄⤒⑓⌮ゎᐊ㸧(2) ◊✲⪅ྡ
ᒣᙧせே
ஂᜏᬛ༤
ᓥ⏣ᛅஅ
ᮡᾆᘯᏊ
ᏲᒇᩗᏊ
Ᏻ⏣ ᪂

(1) ◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

ࢩࢼࣉࢫྍረᛶࡢ␗ᖖ࡜⑌ᝈ㸭ࢩࢼࣉࢫྍረᛶࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᒣᙧせே㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 20 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

A

◊


✲
       ᡂ

E

ᯝ


(3)

ࡽ࠿࡟ࡍࡿࠋᰤ㣴ࠊẕᏊศ㞳ࢫࢺࣞࢫࡀ⬻Ⓨ㐩࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿࡟ࡋࠊ⢭⚄㞀ᐖࠊㄆ▱㞀ᐖ࡬ࡢ㛵୚ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

ᅜෆእࡢ◊✲≧ἣ(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼Heng༤ኈ㸦࣮࢜ࢫࢺࣛࣜ࢔ࠊඹྠ◊✲⪅㸧ࡣRP58ࡀRnd2ࢆ ࣭ RP58ࡢ᭦࡞ࡿୗὶᅉᏊࠊRP58࡜⤖ྜࡍࡿ⺮ⓑࢆ⥙⨶ⓗ࡟ྠᐃ௓ࡋ࡚ᨺᑕ≧⛣ືࢆྖࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
ࡋࠊࢽ࣮ࣗࣟࣥࡢ⏕Ꮡࠊᡂ⇍࡟ᚲ㡲࡛࠶ࡿศᏊ࣓࢝ࢽࢬ࣒ࢆ᫂

(1)(2) ◊✲⪅ྡᒸᡞᬕ⏕ᖹ஭ᚿఙ⏣୰ᬛᏊ㸦2016.4 ╔௵㸧ᖹ஭Ύ⳹ (2014.6 ㌿ฟ)㧗ᶫள⣖௦㸦2011.5 ㌿ฟ㸧Ỉ㔝୍ஓ㸦2011.3 ㌿ฟ㸧୰⏣࿴Ꮚ㸦2011.3 ㌿ฟ㸧୸ᒣ༓⛅㸦2013.3 ㌿ฟ㸧୕㍯᫛Ꮚ㸦2016.4 ㏥⫋㸧◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼


(1)

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ⚄⤒⣽⬊ࡢศ໬࣭⏕Ꮡ࡜ࡑࡢ㞀ᐖࡢศᏊᶵᵓ㸭⚄⤒⣽⬊ศ໬ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᒸᡞᬕ⏕㸧ᴫせ(1) ᡂᯝࡢᴫせPOKᆺ㌿෗ᢚไᅉᏊRP58ࡀࢽ࣮ࣗࣟࣥ๓㥑⣽⬊ࡢ⣽⬊࿘ᮇ ࣭ RP58ࡢࢽ࣮ࣗࣟࣥⓎ㐩࡟࠾ࡅࡿᶵ⬟ⓗព⩏ࡢゎ᫂:▱ⓗ㞀ᐖඣ㞳⬺ࠊᨺᑕ≧⛣ື࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࠊࡑࡢศᏊ࣓࢝ࢽࢬ࣒ࢆ
ࡢ࢚ࢡࢯ࣮࣒ゎᯒ࡟ࡼࡾ,RP58ࡢࢼࣥࢭࣥࢫኚ␗ࠊ࣑ࢫࢭࣥࢫ
᫂ࡽ࠿࡟ࡋ࡚ࡁࡓࠋࡉࡽ࡟ྛࠎࡢゎᯒࢆࡍࡍࡵࠊRP58ࡀ⬻⭘ኚ␗ࡀሗ࿌ࡉࢀࡓࠋࡑࡢ㓄ิࢆ࣐࢘ࢫࡢ኱⬻⓶㉁࡟ࠊᏊᐑෆ࢚
⒆ࡢቑṪ࡜ᝏᛶ໬ࡢ୧⪅ࢆᢚไࡍࡿࡇ࡜ࠊRP58ࡣᡂ⇍ࢽ࣮ࣗࣞࢡࢺ࣏࣮ࣟࣞࢩࣥ࡟࡚ᑟධࡋゎᯒࡋࠊᶵ⬟␗ᖖࢆྠᐃࡋࡓࠋ
ࣟࣥ࡟࠾ࡅࡿᶵ⬟ⓗព⩏ࢆ᫂ࡽ࠿࡟ࡋࡘࡘ࠶ࡿࠋࡉࡽ࡟ࠊᰤ ࣭ RP58ࡢ⬻⭘⒆࡟ᑐࡋ࡚ᢚไⓗ࡟స⏝ࡍࡿࡇ࡜࠿ࡽࡑࡢࢱ࣮ࢤ
㣴⎔ቃࠊẕᏊศ㞳ࢫࢺࣞࢫࡀ⬻ࡢⓎ㐩࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿ࢵࢺࢆ᥈⣴ࡋࡓࠋ࣐࢖ࢡࣟ࢔ࣞ࢖ゎᯒ࡜chip࢔ࢵࢭ࢖࠿ࡽTGFb
࡟ࡋࡘ࠶ࡿࠋ
ཬࡧࡑࡢཷᐜయࠊPDGFཬࡧࡑࡢཷᐜయࡀࢱ࣮ࢤࢵࢺ࡛࠶ࡿࡇ
࡜ࢆ♧ࡋࡓࠋ࣭㉁㔞ศᯒჾࢆ⏝࠸࡚ࠊRP58࡜⤖ྜࡍࡿ⺮ⓑࡢ᥈⣴ࢆ㛤ጞࡋࠊ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼Ctbp㸯➼ࡢ」ᩘೃ⿵ࢆྠᐃࡋࡓࠋRP58ࡢCtbp1⤖ྜ㒊఩ࢆኚ␗࣭ EMBO J
ࡉࡏࡿ࡜㌿෗ᢚไάᛶࡀ༙ῶࡋࠊࢽ࣮ࣗࣟࣥ⛣ືࠊᡂ⇍ࢆ㞀ᐖ࣭ Neuroscienceࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
࣭ Cell Report࣭ ཎ⣴ື≀ࢆ⏝࠸࡚ࠊAMPAᆺGluཷᐜయࡀࠊᯇᯝయᵝගཷᐜჾ࣭ Cerebral Cortex
࣭ PNASᐁᙧᡂࠊኚែ࡟ᚲせ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓࠋ࣭ Brain Research࣭ ẕᏊศ㞳ࢫࢺࣞࢫ࡟ࡼࡾ⾑⟶㞀ᐖࡀぢࡽࢀࠊAPPኚ␗࣊ࢸ࣐ࣟ
࣭ BioEssays࢘ࢫ࡛ࡣࡉࡽ࡟BBBࡢ◚⥢ࠊ࢔࣑ࣟ࢖ࢻ࣮࣋ࢱ⵳✚ࠊㄆ▱ᶵ⬟࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍పୗࡀぢࡽࢀࡓࠋ࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍࣭ 㞳ஙᚋࢩࣙ⢾ࢫࢺࣞࢫ࡛ࡣࠊAGEࡢ⾑⟶ෆ⾑⵳✚ࡀぢࡽࢀࠊࡉ࣭ ᪥ᮏ⏕⌮Ꮫ఍ࡽ࡟Glo1࣊ࢸ࣐ࣟ࢘ࢫ࡛ࡣࠊ⾑⟶ෆࣇ࢕ࣈࣜࣥ⵳✚ࠊ⤫ྜኻㄪ⑕ᵝ⾲⌧ᆺࢆ♧ࡋࡓࠋRP58࣊ࢸ࣐ࣟ࢘ࢫࡣ᪩ᮇ࡟⪁໬࣐࣮࣭࢝ ⤫ྜኻㄪ⑕Ꮫ఍
ࡀฟ⌧ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ୺࡞◊✲ᡂᯝ

－ 21 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

◊


✲
       ᡂ
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E

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(3)

ᅜෆእࡢ◊✲≧ἣ㏆ᖺࠊࢩࢼࣉࢫᙧᡂࡸ⚄⤒⣽⬊⛣ື࡞࡝⚄⤒ᅇ㊰ᙧᡂࡢึᮇ㐣⛬ࡢ␗ᖖࡀࠊᵝࠎ࡞⢭⚄࣭⚄⤒⑌ᝈࡢཎᅉ࡟࡞ࡿࡇ࡜ࡀ
᫂ࡽ࠿࡟ࡉࢀࡘࡘ࠶ࡿࠋᚑࡗ࡚ࠊࡇࢀࡽࡢ⑌ᝈࡢ⑓ᅉࢆゎ᫂ࡋࠊ㐺ษ࡞἞⒪ἲࢆ㛤Ⓨࡍࡿࡓࡵ࡟ࡣࠊ⚄⤒ᅇ㊰ᙧᡂࡢᇶ♏
ⓗ࡞ศᏊᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࡀᚲ㡲࡛࠶ࡿࠋ㏆ᖺࠊࣉࣟࢸ࢜ࢢࣜ࢝ࣥࢆጞࡵ࡜ࡍࡿ⣽⬊እᇶ㉁ࡀࠊ⚄⤒ᅇ㊰ᙧᡂ࡟㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿࡇ࡜ࡀㄆ㆑ࡉࢀࠊࡑࡢᶵ⬟࡜స⏝࣓࢝ࢽࢬ࣒ࡢゎ᫂ࡀᮇᚅࡉࢀ࡚࠸ࡿࠋ

(1)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚NMJࡢ⤒㦂౫Ꮡᆺྍረᛶࡀ࡝ࡢࡼ࠺࡞᝟ሗఏ
㐩⤒㊰࡟ࡼࡗ࡚ไᚚࡉࢀ࡚࠸ࡿࡢ࠿ࠊࡑࡢヲ⣽࡞ศᏊ࣓࢝ࢽࢬ
࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࠋࢩࣙ࢘ࢪࣙ࢘ࣂ࢚NMJࡣࠊᵝࠎ࡞⚄⤒ኚᛶ⑌ᝈࡢࣔࢹࣝ࡜ࡋ࡚⏝࠸ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ࡣࡑࢀࡽ⚄⤒ኚᛶ⑌ᝈࡢ⑓ែゎ᫂࡟ࡘ࡞ࡀࡿࠋ࣭ ᨺᑕ≧⚄⤒⣽⬊⛣ື࡟కࡗ࡚኱ࡁ࡞Ⓨ⌧ኚ໬ࢆ♧ࡍ⣽⬊እᇶ㉁ᡂศཬࡧࢩࢼࣉࢫ㛵㐃ศᏊ࡟ࡘ࠸࡚ࠊࡑࡢ⣽⬊⛣ືไᚚ࡟࠾ࡅ
ࡿᶵ⬟ࢆࠊ࣐࢘ࢫᏊᐑෆ⫾௘㟁Ẽ✸Ꮝἲ➼ࢆ⏝࠸࡚ヲ⣽࡟ゎᯒࡍࡿࠋᨺᑕ≧⚄⤒⣽⬊⛣ືࡢ␗ᖖࡣࠊ⁥⬻⑕➼ࡢ⬻ወᙧࠊࡉࡽ
࡟⤫ྜኻㄪ⑕ࡸ⮬㛢⑕➼ࡢ⢭⚄⑌ᝈࡢཎᅉ࡟࡞ࡿ࡜⪃࠼ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ࡣࡇࢀࡽࡢ⑌ᝈࡢ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡀࡿࠋ

(2)

E

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㸦࠾ⲔࡢỈዪᏊ኱኱Ꮫ㝔㸧

࣭◊ಟ⏕
㔠Ꮚ஀ឡ
୸ ᬛ㤶Ꮚ

㸦ி㒔ᗓ❧་኱㸧㔝ᮧ ┿㸦࠾ⲔࡢỈዪᏊ኱㸧࣭ᐈဨ◊✲ဨ⏤Ⰻ ᩗ(2) ◊✲⪅ྡ
࣭◊✲ဨ
๓⏣ಙ᫂
୸ᒣ༓⛅
⚄ᮧᆂு

(1)

◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

⚄⤒ᅇ㊰ࡢᙧᡂ࡜ࡑࡢⓎ㐩␗ᖖࡢ࣓࢝ࢽࢬ࣒㸭⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸๓⏣ಙ᫂㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ(1) ᡂᯝࡢᴫせᴫせ⚄⤒ᅇ㊰ࡢᙧᡂ࡜ࡑࡢⓎ㐩␗ᖖࡢศᏊᶵᵓࢆࠊࣉࣟࢸ࢜ࢢ ձ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⚄⤒ᅇ㊰ᙧᡂ࡟࠾ࡅࡿࣉࣟࢸ࢜ࢢ
ࣜ࢝ࣥࡢᶵ⬟ゎᯒࣜ࢝ࣥࢆጞࡵ࡜ࡍࡿ⣽⬊እᇶ㉁࡟ὀ┠ࡋ࡚ゎ᫂ࡋࠊᚓࡽࢀࡓ
࣭ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᗂ⹸ࡣ㣚㣹≧ែ࡟㝗ࡿ࡜άⓎ࡟⛣ືࡍࡿࡼ࠺
▱ぢࢆ㍈⣴෌⏕ࡸ⢭⚄࣭⚄⤒⑌ᝈࡢ἞⒪ᡓ␎࡬࡜ᛂ⏝ࡍࡿࡇ࡟࡞ࡿࡀࠊࡑࢀ࡜ඹ࡟⚄⤒➽᥋ྜ㒊㸦NMJ㸧࡟࠾ࡅࡿࢩࢼࣉࢫ
࡜ࢆ┠ᣦࡍࠋ
࣎ࢱࣥࡢ᪂⏕ࡀㄏᑟࡉࢀࡿ㸦⤒㦂౫Ꮡᆺྍረᛶ㸧ࠋᮏᖺᗘࡣࠊ
࣊ࣃࣛࣥ◲㓟ࣉࣟࢸ࢜ࢢࣜ࢝ࣥࡢ୍ࡘࢢࣜࣆ࢝ࣥࡀࠊBMPࢩࢢ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ࢼࣝࢆᢚไࡍࡿࡇ࡜࡟ࡼࡗ࡚⤒㦂౫Ꮡᆺྍረᛶࢆไᚚࡋ࡚࠸ࡿ
࣭ Scienceࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࠊ⌧ᅾㄽᩥࢆᢞ✏୰࡛࠶ࡿࠋ
࣭ Journal of Cell Biologyղ ࣐࢘ࢫ኱⬻⓶㉁ᙧᡂ࡟࠾ࡅࡿ⚄⤒⣽⬊⛣ືࡢไᚚᶵᵓ
࣭ Cell Reports࣭኱⬻᪂⓶㉁ࡢ⯆ዧᛶࢽ࣮ࣗࣟࣥࡣࠊ⓶㉁῝㒊࡛ㄌ⏕ࡋࡓᚋࠊ࣭ Development⬻⾲࡟ྥ࠿ࡗ࡚㡰ḟ⛣ືࡋ࡚࠸ࡃ㸦ᨺᑕ≧⚄⤒⣽⬊⛣ື㸧ࠋ࣭ Frontiers in Neuroscienceᮏᖺᗘࡣࠊ᫖ᖺᗘぢฟࡋࡓࠊࢧࣈࣉ࣮ࣞࢺᒙࡀᨺᑕ≧⚄⤒⣽࣭ Biochim Biophys Acta.
⬊⛣ືࡢไᚚ࡟㔜せ࡞ാࡁࢆࡋ࡚࠸ࡿࡇ࡜࡟ࡘ࠸࡚ゎᯒࢆࡉ࣭ ᪥ᮏ⏕໬Ꮫ఍
ࡽ࡟㐍ࡵࡓࠋ≉࡟ࢧࣈࣉ࣮ࣞࢺᒙ࡟Ꮡᅾࡍࡿ⣽⬊እᇶ㉁ࡢᙺ
࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍๭ࢆㄪ࡭ࠊࣉࣟࢸ࢔࣮ࢮ࡛࠶ࡿ ADAMTS2 ࡀࠊ⚄⤒⣽⬊⛣ື࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍ไᚚ࡟㔜せ࡞ᶵ⬟ࢆᯝࡓࡍࡇ࡜ࢆぢฟࡋࡓࠋ୺࡞◊✲ᡂᯝ

－ 22 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

◊


✲
       ᡂ

E

ᯝ


ࡽ࠿࡟ࡍࡿ◊✲ࡣࠊᮾி㒔࡛ࡢ኱つᶍᆅ㟈ࡀண᝿ࡉࢀࡿ⌧≧࡟࠾࠸࡚ព⩏ࡀ኱ࡁ࠸ࠋ

᫬ࠊ13ṓ᫬ࡢ୧᫬Ⅼ࡛࣌ࣥࢺࢩࢪࣥ⃰ᗘࡀప࠸⩌࡛ࡣࠊᗁ⫈య㦂⋡ࡀࢮࣟ㸣࡛࠶ࡗࡓࡢ࡟ᑐࡋࠊ୧᫬Ⅼ࡛㧗࠸⩌࡛ࡣࡑࢀࡀ30%࡟ࡶཬ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ࡪࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࡢࡇ࡜࠿ࡽᛮ᫓ᮇࡢ࣌ࣥࢺࢩࢪࣥࡢ⦪
࣭ Nishida A et al (2018) J Psychiatr Res, 102: 136-141.
᩿㌶㊧ࡀᗁ⫈ࢆண ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
࣭ Yamasaki S et al (2019) Schizophr Res, 206: 52-57.
࣭ㄆ▱⑕ࡢேࡢᅾᏯ⏕άࢆᨭ᥼ࡍࡿࢣ࢔ࣔࢹࣝࡢ㛤Ⓨ㸸᫖ᖺᗘࡲ࡛࡟
࣭ Naknishi M et al (2018) J Alzheimers Dis 64: 515-523.
ຠᯝ᳨ドࢆ᏶஢ࡋࡓㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛࢆ඲㒔ⓗ࡟ᬑཬࡍࡿࡓࡵ
࣭ Ando S et al (2019) PLoS One 14: e0214359.
࡟㸦ᮾி㒔ᐇ⾜ࣉࣛࣥ㸧ࠊᮾி㒔ࡸ⮬἞య࡜㐃ᦠࡋ࡚ㄝ᫂఍ࠊ◊ಟ࣭ Iijima Y et al (2019) J Affect Disord 246: 89-95.
఍➼ࢆ✚ᴟⓗ࡟⾜ࡗࡓࠋඵ⋤Ꮚᕷࠊୡ⏣㇂༊ࠊ㊊❧༊ࢆࡣࡌࡵィ8ࡘ
࣭ Hirooka K et al (2018) Cogent Med 5: e1483097.
ࡢ⮬἞యࡀ◊ಟ఍ཧຍࡋࠊ⣙150ྡࡢᐇ㊶⪅ࢆ㣴ᡂࡋࡓࠋ࣭ Morimoto Y et al (2018) BMJ Open 8: e020586.
࣭ ⢭⚄⛉࣏ࢫࢺᩆᛴࡢࢣ࢔ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨ㸸๓ᖺᗘࡲ࡛ࡢどᐹㄪᰝ࣭ Ando S & Nishida A et al (2018) J Affect Disord 238: 359-365.
࣭ Shimodera S & Nishida A et al (2018) Schizophr Res 201: 294-298.
➼ࡢᡂᯝࢆ㋃ࡲ࠼ࠊ⢭⚄⛉⑓㝔ࡢ་⒪ᚑ஦⪅ࢆᑐ㇟࡜ࡋࡓࢺ࣐ࣛ࢘
࣭ Nakanishi M et al (2019) BJPsych Open 5: e10࣭࢖ࣥࣇ࢛࣮࣒ࢻ࣭ࢣ࢔㸦TIC㸧ࣉࣟࢢ࣒ࣛࢆ㛤Ⓨࡋࠊ㒔ෆࡢ⢭⚄࣭ Fujikawa S et al (2018) J Adolesc 68: 207-216⛉⑓㝔ࢫࢱࢵࣇ65ྡࢆᑐ㇟࡜ࡋࡓຠᯝ᳨ド◊✲ࢆᐇ᪋ࡋࡓࠋ⤖ᯝࠊ࣭ Okada N et al (2019) Sci Rep 9(1): 732
௓ධຠᯝࡢᣢ⥆ᛶࡀ☜ㄆࡉࢀࠊᅜ㝿Ꮫ⾡ㄅ࡟ሗ࿌ࡋࡓࠋ࣭ ⿕⅏⪅➼ࡢ⢭⚄ⓗ೺ᗣணᚋ࡟㛵ࡍࡿࢥ࣮࣍ࢺ◊✲㸸⿕⅏ᆅ୍⯡ఫẸ(3) ᅜෆእࡢ◊✲≧ἣ⢭⚄ಖ೺ࢥ࣮࣍ࢺ◊✲ࠊᛴᛶෙ⑕ೃ⩌ࢥ࣮࣍ࢺ◊✲࡜ࡶ࡟୍᫖ᖺᗘ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࣉࣟࢪ࢙ࢡࢺࡣࢃࡀᅜึ࡛࠶ࡾࠊᛮ᫓
ࡲ࡛࡟ᙜึࡢ◊✲ィ⏬࡜ㄽᩥ໬సᴗࢆ㐩ᡂࡋ᏶஢ࡋ࡚࠸ࡿࠋ
ᮇࢆ⦪᩿㏣㊧ࡋࠊ⢭⚄⑓⌮➼ࡢᙧᡂࣉࣟࢭࢫ࡟ᙳ㡪ࢆ୚࠼ࡿせᅉ➼(2)
௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࢆゎ᫂ࡍࡿព⩏ࡣ኱ࡁ࠸ࠋㄆ▱⑕ࡢேࡢ⾜ືᚰ⌮⑕≧ࡢᑐᛂ࡜┳ྲྀ࣭኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺ◊✲ࡢ10࣭12࣭14ṓ᫬ࢹ࣮ࢱࢆ㐃⤖ࡉࡏࠊ⦪ࡾࢆᨭ࠼ࡿࢣ࢔ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨࡣྛᅜㄆ▱⑕᪋⟇ࡸ◊✲ࡢ↔Ⅼ࡜᩿ࢹ࣮ࢱゎᯒࠊࡑࢀ࡟ᇶ࡙ࡃㄽᩥ໬ࢆ㐍ࡵࡿࠋ16ṓ᫬ㄪᰝࢆ╔ᐇ࡟࡞ࡗ࡚࠸ࡿࡀࠊᡃࡀᅜ࡛ྲྀࡾ⤌ࢇ࡛࠸ࡿᶵ㛵ࡣஈࡋ࠸ࠋ⿕⅏ఫẸࡢ㐍ࡵࡿࠋㄆ▱⑕ࢣ࢔ࣉࣟࢢ࣒ࣛࡢᬑཬ࡟ྥࡅࡓᒎ㛤ࢆᮾி㒔࠾ࡼࡧ࣓ࣥࢱࣝ࣊ࣝࢫࡢ⤒᫬ⓗኚ໬ࢆ㋃ࡲ࠼ࠊ᫬ᮇ࡟ᛂࡌࡓᨭ᥼ㄢ㢟ࢆ᫂༠ຊ⮬἞య࡜㐃ᦠࡋ࡚᥎㐍ࡍࡿࠋ

(1)

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦㐃ᦠ◊✲ဨ㸧
ྂᕝኖு
ᕝୖ᠇ே
➟஭ΎⓏ
బࠎᮌྖ
Ᏹబ⨾្
㐍⸨⏤⨾
ᐑᮏ᭷⣖

㸦༠ຊ◊✲ဨ㸧⟄஭༟ᐇ(2) ◊✲⪅ྡ
す⏣῟ᚿ
ᒣᓮಟ㐨
୰す୕᫓
ዟᮧὈஅ
᪂ᮧ㡰Ꮚ
㐲⸨㤶⧊
㣤ᓥ㞝኱
ᘅᒸె௦
Ᏻ⸨ಇኴ㑻㸦ᐈဨ㸧ᑠụ㐍௓㸦ᐈဨ㸧㣕㫽஭ᮃ㸦ᐈဨ㸧(1)◊✲ᮇ㛫2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾᚰࡢ೺ᗣ࡙ࡃࡾࡢࡓࡵࡢண㜵࣭἞⒪࣭ࣜࣁࣅࣜἲ㸭ᚰࡢ೺ᗣࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸す⏣῟ᚿ㸧ᴫせ(1) ᡂᯝࡢᴫせᚰࡢ೺ᗣࡣࠊಶேࡢ⏕άࡢ㉁ࢆ኱ࡁࡃᕥྑࡍࡿࠋࡇ࡜࡟኱㒔 ࣭ ᛮ᫓ᮇ࣓ࣥࢱࣝ࣊ࣝࢫ࡜࢙࣭࢘ࣝࣅ࣮࢖ࣥࢢࡢᐤ୚ᅉᏊゎ᫂㸸㒔ෆ3⮬἞య࡜㐃ᦠࡋࡓ኱つᶍᛮ᫓ᮇࢥ࣮࣍ࢺㄪᰝ㸦Tokyo Teen Cohortᕷࡢ⏕ά⪅ࡣࠊᚰࡢ೺ᗣࢆ⼃ࡴࡉࡲࡊࡲ࡞せᅉ࡟᫹ࡉࢀࡿࠋᑡ
Study, N=3171㸧ࡣࠊ14ṓ᫬㏣㊧ゼၥㄪᰝ㸦➨3ᅇㄪᰝ㸧ࢆணᐃ㏻ࡾᏊ㧗㱋໬ࡀ㐍ࡴᮾி࡟࠾࠸࡚ࠊᏊ࡝ࡶ࣭ⱝ⪅ࡢ࣓ࣥࢱࣝ࣊ࣝࢫ
᏶஢ࡋࡓ㸦㏣㊧⋡85㸣㸧ࠋ⌧ᅾࠊ16ṓ᫬㏣㊧ゼၥㄪᰝ㸦➨4ᅇㄪᰝ㸧ࡸ⮬ẅࠊㄆ▱⑕ࢆࡣࡌࡵ࡜ࡍࡿᚰࡢ೺ᗣၥ㢟ࡣࠊ㒔Ẹࡢࡃࡽࡋࡀᙜึィ⏬࡟ࡑࡗ࡚㡰ㄪ࡟㐍⾜୰࡛࠶ࡿࠋࡲࡓࠊTokyo Teen Cohort࡜೺ᗣ࡟㛵ࢃࡿႚ⥭ࡢၥ㢟࡛࠶ࡿࠋ༊࣭ᕷ࡜㐃ᦠࡋࡓ኱つᶍฟࡢ⣙1/10ࡢཧຍ⪅ࢆᑐ㇟࡟ᐇ᪋ࡋ࡚࠸ࡿ᮶ᡤᆺࢧࣈࢧࣥࣉࣝㄪᰝ
⏕ࢥ࣮࣍ࢺ◊✲࡟ࡼࡿᏊ࡝ࡶ࣭ⱝ⪅ࡢ⢭⚄ⓗ೺ᗣࡸ࢙࣭࢘ࣝࣅ
ࡶࠊ➨2ᅇࡢ⦪᩿ㄪᰝࢆ↓஦᏶஢ࡋࡓࠋ௒ᖺᗘࡣࠊࡇࢀࡲ࡛࡟ᚓࡽࢀ
࣮࢖ࣥࢢ࡟㛵ࡍࡿᐇドⓗᡂᯝࡸ⮫ᗋ࣭ࢣ࢔⌧ሙ࡜ࡢ༠ാ࡟ࡼࡿ
ࡓࣂ࢖᳨࢜యࡢゎᯒࢆ㐍ࡵࠊ≉࡟௦⾲ⓗ࡞⤊ᮎ⢾໬⏘≀࡛࠶ࡿ࣌ࣥ
ㄆ▱⑕࣭⢭⚄㞀ᐖࡢᆅᇦࢣ࢔ࣉࣟࢢ࣒ࣛ㛤Ⓨ➼ࠊ♫఍་Ꮫⓗ᪉ࢺࢩࢪࣥࡢᛮ᫓ᮇኚື࡜࣓ࣥࢱࣝ࣊ࣝࢫ࡜ࡢ㛵㐃ࢆ᳨ドࡋࡓࠋ12ṓἲ࡟ࡼࡿᚰࡢ೺ᗣ࡙ࡃࡾ◊✲ࡢ♫఍㑏ඖࡀồࡵࡽࢀ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ

－ 23 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

A

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E

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  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦㠀ᖖ໅⫋ဨ㸧
㕥ᮌ୍ᾈ
ྜྷᕝ ⲁ
ᑠᖭ⳯ࠎᏊ
㔝ཎ Ἠ
␊୰┿⾰
㨣㢌⫱௦
᳃ ᬡ
ᑠᇼᬗᏊ
஭ୖᬛᏊ
℈⤮⨾Ꮚ
ᔲ⏣⏤㈗Ꮚ
▼⏣▱ྍᏊ

(2) ◊✲⪅ྡ㸦ᖖ໅⫋ဨ㸧
⣒ᕝᫀᡂ
ᇼෆὈỤ
ᐑୗගᘯ
㫽ᾏ࿴ஓ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ⤫ྜኻㄪ⑕ࡢཎᅉ✲᫂࡜ண㜵࣭἞⒪ἲࡢ㛤Ⓨ㸭⤫ྜኻㄪ⑕ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸᪂஭ ㄔ㸧ᴫ せ㸸⤫ྜኻㄪ⑕ࡢศᏊᇶ┙࡟ࡘ࠸࡚ࠕ⢾໬ࢫࢺࣞࢫ㸦࢝ࣝ࣎ࢽࣝ (1) ᡂᯝࡢᴫせࢫࢺࣞࢫ, CS㸧ࠖࢆ㍈࡟ࠊ⏕⌮᳨యࠊ๗᳨⬻ࠊ⣽⬊ࣔࢹࣝࠊື≀ࣔձ ⏕⌮᳨య࡟࠾ࡅࡿ௦ㅰ⏘≀࣐࣮࣮࢝ࣉࣟࣇ࢓࢖ࣝ㸸㌄࠺ࡘ⑓㸦BP㸧ࢹࣝ࠿ࡽከ㠃ⓗ࡟᳨ドࡋࠊᙜ஦⪅ࢽ࣮ࢬ࡟ࡑࡗࡓ೺ᗣᅇ᚟࡬ࡢྲྀࡾ
23ྡࠊ࠺ࡘ⑓㸦Dep㸧39ྡࠊ೺ᖖ⪅㸦CT㸧72ྡࢆᑐ㇟࡟ࠊ࢝ࣝ࣎ࢽࣝ
⤌ࡳࢆࡵࡊࡍࠋ
ࢫࢺࣞࢫ(CS)࣐࣮࣮࢝ࢆẚ㍑᳨ウࡋࡓ⤖ᯝࠊSZࠊBP࡛ࡣCT࡜ẚ㍑ࡋ
࡚࣌ࣥࢺࢩࢪࣥ(PEN)್ࡀ᭷ព࡟ቑຍࡋࠊࣅࢱ࣑ࣥB6(VB6)್ࡣ᭷ព
ㄽ ᩥ ᥖ ㍕ ㄅ ࣭ Ⓨ ⾲ Ꮫ ఍ ྡ ➼ 㸸  Mizutani R, et al. Translational࡟ῶᑡࡋࡓࠋ⑌ᝈẖࡢCS๭ྜࡣࠊSZࡀ17.3%ࠊBPࡀ17.4%࡟ᑐࡋࠊ
Psychiatry 2019; Yamasaki S, et al. Schizophr Res. 2018; Kushima I, et al.
Depࡀ7.7%ࠊ೺ᖖ⪅ࡣ1.4%࡛࠶ࡗࡓࠋ
Cell Rep. 2018; Saiga R, et al. Microsc. Microanal., 2018; Ikeda M, et al.
Mol Psychiatry. 2018; Itokawa M, et al. Psychiatry Clin Neurosci. 2018; ղ ࣐࢘ࢫࣔࢹࣝࢆ฼⏝ࡋࡓศᏊᇶ┙ࡢゎ᫂㸸Glo1㑇ఏᏊḞᦆࠊཬࡧ
VB6Ḟஈ༢⊂࡛ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ⾜ືࡢ㞀ᐖࡀㄆࡵࡽࢀࡿࡇ࡜ࡀ᫂
⣒ᕝᫀᡂ. PSYCHIATRY 2019;᪂஭ㄔࡽ⮫ᗋ⢭⚄་Ꮫ 2019.; ᪂஭ㄔ.
ࡽ࠿࡜࡞ࡗࡓࠋࡇࢀࡽ࣐࢘ࢫࢆ⏝࠸ࠊ๓㢌⓶㉁࡟࠾ࡅࡿ㟁Ẽ⏕⌮Ꮫⓗ
JMARS Letter 2018; Mizutani R, et al. Biological Physics 2018; Mizutani࡞ኚ໬࡟ࡘ࠸᳨࡚ウࢆ⾜࡞ࡗࡓ࡜ࡇࢁ⤌ࡳྜࢃࡏࡓ⩌࡟࠾࠸࡚ࠊ㟼ṆR, et al. Microsc. Microanal. 2018; ⣒ᕝᫀᡂ ࡇࡇࢁࡢ⛉Ꮫ 2018; ⣒⭷㟁఩ࡢቑຍࡀㄆࡵࡽࢀࠊάື㟁఩ࡀⓎ⏕ࡋࡸࡍ࠸≧ែ࡛࠶ࡿࡇ࡜ࡀ
ᕝᫀᡂ.ୡ⏣㇂ࡉࡃࡽ఍ .2018; ⣒ᕝᫀᡂ.⢭⚄ಖ೺་⒪⚟♴ⓑ᭩ 2018
ぢฟࡉࢀࡓࠋࣆࣜࢻ࢟ࢧ࣑ࣥ㸦PM㸧ᢞ୚࣐࢘ࢫࣔࢹࣝ࡟࠾࠸࡚ࠊ㔝; Itokawa M. Recovery “Easy Go Farm” 2018; ⣒ᕝᫀᡂ.㑇ఏ་Ꮫ◊✲⏕ᆺ࣐࢘ࢫC57BL/6J࡟PM ࢆ2㐌㛫㐃⥆ᢞ୚ࡋࠊ⬻ෆࣔࣀ࢔࣑ࣥཬࡧᐊ ࡢṌࡳϨ . 2018; ⣒ᕝᫀᡂࡽ㸪 ≉㞟 I⤫ྜኻㄪ⑕◊✲᭱๓⥺ 2018;࢔࣑ࣀ㓟ࡢኚ໬࡟ࡘ࠸࡚HPLC ᐃࢆ⾜࡞ࡗࡓ⤖ᯝࠊ࢔࣑ࣀ㓟ࡢኚື⣒ᕝᫀᡂ.㒆ᒣ⢭⚄་⒪ ➨ 32ྕ . 2018;⣒ᕝᫀᡂ.ᚰࡢࣜࣁࣅࣜࠕᴦᴦ
ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࡀࠊࣔࣀ࢔࣑ࣥ࡟㛵ࡋ࡚ࡣഃᆘ᰾ࠊ⥺᮲య࡟࠾ࡅ
㎰ᅬࠖ 2018; ᐑୗගᘯࡽ⢭⚄⚄⤒Ꮫ㞧ㄅ 2018; ᇼෆὈỤࡽ⢭⚄⛉⮫ࡿ᭷ព࡞ኚ໬ࡀㄆࡵࡽࢀࠊPMࡢ἞㦂࡛ㄆࡵࡽࢀࡓᡤぢ࡜୍⮴ࡋࡓ⤖ᗋ Legato.2018; ᪂஭ㄔ Neuroscience 2018; ᇼෆὈỤ Neuroscienceᯝࡀᚓࡽࢀࡓࠋ
2018;ᇼෆὈỤ ᪥ᮏே㢮㑇ఏᏛ఍኱ 63ᅇ኱఍ 2018;⣒ᕝᫀᡂ ➨ 7
ᅇ ᪥ ᮏ ⢭ ⚄ ⛉ ་ Ꮫ ఍ Ꮫ ⾡ ኱ ఍ 2018; ᇼ ෆ Ὀ Ụ 18th WPA World ճ ་ᖌ୺ᑟᆺ἞㦂㸸10౛୰2౛࡛⢭⚄⑕≧ࡢⴭ᫂࡞ᨵၿ㸦≉࡟㝜ᛶ⑕≧㸧ࢆㄆࡵࠊGLO1ኚ␗ࢆ᭷ࡍࡿ⿕㦂⪅࡛ࡣࠊPENῶᑡ࡜ྠ᫬࡟⢭⚄Congress of Psychiatry 2018;᪂஭ㄔ ➨ 91ᅇ᪥ᮏ⏕໬Ꮫ఍ 2018; ᪂⑕≧ࡣ୰➼ᗘ࡟ᨵၿࡋࡓࠋࡲࡓࠊ⸆๣ᛶ㗹యእ㊰⑕≧ࡣ4౛࡛ᨵၿ஭ ㄔ  ➨ 91 ᅇ ᪥ ᮏ ⏕ ໬ Ꮫ ఍ 2018;Arai M, et al. 13th IMARS,2018;ࡋࠊࡉࡽ࡟౽⛎ࡸ⸆๣ᛶ↓᭶⤒ࡢᅇ᚟࡞࡝ࡶㄆࡵࡓࠋ2018ᖺ10᭶ࡼࡾ
Toriumi K, et al. 13th IMARS,, 2018; Itokawa M. WFSBP/JSBP Joint⯆࿴ᰴᘧ఍♫ࡀ➨II┦ࣉࣛࢭ࣎ᑐ↷ẚ㍑ヨ㦂ࢆ㛤ጞࡋࡓࠋ
Symposium 2018; Itokawa M. Chairs. WFSBP 2018; Miyashita M, et al.➨40 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍࣭➨ 61 ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍  2018;
Y Horiuchi,et al. SfN 2018; Itokawa M. Pan-Asia Symposium on The (2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼
Genetics Of Brain Disorders. 2018; Itokawa M. Pan-Asia Symposium on ձ⢾໬࣭㓟໬࣐࣮࣮࢝ࢆ㍈࡟ࡋ࡚ᇶ♏࣭⮫ᗋ᝟ሗࡢໟᣓⓗ࠿ࡘ⦪᩿ⓗ
The Genetics Of Brain Disorders. 2018; Itokawa M. Precision Medicine ࡞ࢹ࣮ࢱ࣮࣋ࢫᵓ⠏ࢆ⥅⥆ࡋࠊ⑓ែࡢணᚋண ࡸ⑌ᝈ≉␗ᛶࠊ᪩ᮇデ
Strategy to Brain Disorders. 2018; ⣒ᕝᫀᡂ ➨114ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ ᩿࣐࣮࣮࢝࡜ࡋ࡚ࡢጇᙜᛶࠊ࣐࣮࣮࢝ࡢᅉᯝ㛵ಀࢆ᫂ࡽ࠿࡟ࡍࡿࠋղ
఍Ꮫ⾡⥲఍  2018; ⣒ᕝᫀᡂ. ➨ 114 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍ . ື≀࣭⣽⬊ࣔࢹࣝࢆά⏝ࡋࠊ௦ㅰኚືࠊ⚄⤒✺㉳ఙ㛗࡞࡝ࡢᙧែᏛⓗ2018;; K Suzuki,. SfN 2018;; M Arai, et al. SfN 2018;௚ࠊ኱Ꮫㅮ⩏➼࡞᳨ウࢆ⾜࠺ࠋᢠ⢾໬࣭㓟໬ࢆⓎ᥹ࡍࡿbioactivesࡢศᏊᶵᗎ࡜ࡑࡢ᭷ຠᛶࢆホ౯ࡍࡿࠋճ⏘Ꮫ㐃ᦠ࡟ࡼࡿ⢾໬ࢫࢺࣞࢫ ᐃᶵჾࡢ㐺ᛂ࡜ᑟᅜෆእࡢ◊✲≧ἣ㸸CSᛶࡢ⤫ྜኻㄪ⑕10ྡࢆᑐ㇟࡟ࣆࣜࢻ࢟ࢧ࣑ ධࢆᅗࡾࠊᮍ᭹⸆⑕౛ࡸ๓ྥࡁࢥ࣮࣍ࢺ᳨య࡛ࡢ᭷⏝ᛶࡢ᳨ド࡬ᒎ㛤ࣥ(PM)ࢆ⏝࠸ࡓ་ᖌ୺ᑟ἞㦂ࢆ㒔❧ᯇἑ⑓㝔࡟࠾࠸࡚ᐇ᪋ࡋࠊࡑࡢ ࡍࡿࠋմPM࡟ࡼࡿ➨II, III┦ヨ㦂ᐇ᪋࡟ྥࡅࡓ༠㆟ࢆ⥅⥆ࡍࡿࠋຠᯝࢆ᭷ ຠ ᛶ ࡟ ࡘ ࠸࡚ ㄽ ᩥ ࡜ࡋ ࡚ሗ ࿌ 㸦 Itokawa M et al. Psychiatry Clin ♧ࡍ⩌ࡢ⮫ᗋ≉ᚩࠊ⏕໬Ꮫ࣭ศᏊࡢኚ໬ࢆゎᯒࡋ࡚⑓ែᇶ┙ࢆゎ᫂ࡍ
Neurosci. 2018㸧ࡋࡓࠋ⌧ᅾࠊPhase IIb἞㦂୰ࠋࡿࠋ୺࡞◊✲ᡂᯝ

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(1) ᡂᯝࡢᴫせ➨㸱ᮇࣉࣟࢪ࢙ࢡࢺ࡟ධࡾࠊ♫఍ᩋ໭ࢫࢺࣞࢫࢆ⏝࠸ࡓ᪂つ㞴἞ᛶ࠺ࡘ⑓ࣔࢹࣝࢆ㛤Ⓨࡋࡓࠋࡇࡢࣔࢹ࡛ࣝࡣ࠺ࡘ⑓ᵝࡢᅇ㑊⾜ືࡀ࡯ࡰ100%࡛ฟ⌧ࡍࡿࠋࡲࡓEEG㸦⬻Ἴ㸧࡟ࡼࡗ࡚ࠊ࠺ࡘ⑓ᵝ୙╀≧ែࡀฟ⌧ࠊᢠ࠺ࡘ⸆࡛ᨵၿࡍࡿࡇ࡜ࢆ☜ㄆࡋࡓࠋࡍ࡞ࢃࡕෆᅉᛶࠊࢫࢺࣞࢫ
ᛶࡶྵࡵࠊ࠺ࡘ≧ែࡢ⑓ែࣔࢹࣝ࡜ᡂࡾᚓࡿࠋᢠ⅖⑕స⏝ࡢ࠶ࡿ≀㉁ࢆࡉࡲࡊࡲ⏝࠸ࠊ࡯ࡰ඲࡚ࡢᢠ⅖⑕≀㉁࡟࠺ࡘ≧ែᨵၿຠᯝࡀ࠶ࡿࡇ
࡜ࡀุ᫂ࡋࡓࠋ⏘Ꮫ㐃ᦠ◊✲࡛᪂ࡓ࡞ᢠ࠺ࡘ≀㉁ࢆⓎぢࡋࠊ⌧ᅾ≀㉁≉チ⏦ㄳࢆ‽ഛ୰࡛࠶ࡿࠋࡉࡽ࡟ࠊࣔࢹࣝ࠿ࡽEEG␗ᖖࠊ⾑ᾮࣂ࢖࣐࣮࣮࢜࢝ࠊ⣅౽୰≀㉁࡞࡝ࠊᐈほⓗデ᩿ἲࡢ✀ࢆぢฟࡋࡓࠋ௒ᚋࡣࣄ
ࢺ࡬ࡢᛂ⏝ࢆ┠ᣦࡍ㸦ㄽᩥసᡂ୰㸧ࠋᡂ య ⬻ ⏤ ᮶ aOPC ᇵ 㣴 ἲ ࡢ ☜ ❧ ࡞ ࡝ ࢆ ⾜ ࠸ ࠊ ᪂ つ aOPC ࣐ ࣮ ࢝ ࣮
plexin-B3ࢆⓎぢࡋࠊ௒ࡲ࡛ㅦࡀከ࠿ࡗࡓaOPCࡢ⬻ෆືែࡢ᪂ࡓ࡞ഃ㠃ࢆ᫂ࡽ࠿࡟ࡋࡘࡘ࠶ࡿࠋࡶ࡜ࡶ࡜aOPCࡣᡂேᮇࡢࢢࣜ࢔⣽⬊ࡢ୰࡛ࠊ᭱ࡶᩘࡀከ࠸୍᪉ࠊࡑࡢᶵ⬟ゎ᫂ࡣ㐜ࢀ࡚࠸ࡓࠋ㦫࠸ࡓࡇ࡜࡟ୖ㏙ࡢ
᪂つaOPC࣐࣮࣮࢝࡜ADࡢ୺せ⑓ኚ࡛࠶ࡿ࢔࣑ࣟ࢖ࢻ⵳✚࡟㛵㐃ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸦≉㢪῭㸧㸦ㄽᩥసᡂ୰㸧ࠋྠⓎぢࡣᚑ᮶ࡢ࢔࣑ࣟ
࢖ࢻ௬ㄝࡢぢ┤ࡋࡢᚲせᛶࢆ♧၀ࡋ࡚࠾ࡾࠊ᪂ࡓ࡞ほⅬ࠿ࡽࡢ᰿ᮏⓗ἞⒪⸆㛤Ⓨ࡟ࡘ࡞ࡀࡿࠋࡲࡓࠊaOPCࡢ᪂ࡓ࡞ᶵ⬟ゎᯒ࡛ࡶࠊࢢࣜࢩࣥ
ࡢศἪ⣽⬊ࡢྍ⬟ᛶ࡞࡝ࠊࡉࡲࡊࡲ࡞᪂▱ぢࡀฟ࡚࠸ࡿࠋ⎔ቃᅉᏊࡢᅜ㝿ඹྠ◊✲࡛ࡣኴ㝧ග࡜཮ᴟᛶ㞀ᐖࡢⓎ⑕࡟㛵㐃ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࠊඹྠⴭ⪅࡜ࡋ࡚ㄽᩥࢆ᪂ࡓ࡟ᩘሗࣃࣈࣜࢵࢩࣗࡋࡓࠋࡉࡽ࡟࢖ࣥ
ࢱ࣮ࢿࢵࢺ౑⏝࡟㛵ࡍࡿᅜ㝿࢔ࣥࢣ࣮ࢺㄪᰝ࡟ࡶᘬࡁ⥆ࡁཧຍ୰࡛࠶
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⸆ࡢ㛤Ⓨ◊✲ࢆࠊ⏘Ꮫ㐃ᦠ◊✲ࢆ㏻ࡌ࡚⾜࠺ࠋࡉࡲࡊࡲ࡞⎔ቃᅉᏊ࡜Ẽศ㞀ᐖⓎ⑕࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

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ᴙᯘ⩏Ꮥ
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(1)

◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ࠺ࡘ⑓ࡢཎᅉ✲᫂࡜デ᩿࣭἞⒪ἲࡢ㛤Ⓨ㸭࠺ࡘ⑓ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᴙᯘ⩏Ꮥ㸧ᅜෆእࡢ◊✲≧ἣᑡᏊ㧗㱋♫఍ࢆ㏄࠼ࠊ࠺ࡘ⑓࡞࡝ࢫࢺࣞࢫᛶ⢭⚄⑌ᝈ◊✲ (2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࣔࢹࣝື≀◊✲࡜aOPC࡜ADࡢ㛵㐃◊✲ࢆᘬࡁ⥆ࡁ⾜࠺ࠋࣔࢹࣝື
ࡸAD࡜ࡢ㛵㐃◊✲ࡣࡲࡍࡲࡍ㔜せ࡜࡞ࡗ࡚࠾ࡾୡ⏺ⓗ࡞኱➇≀࡛ぢࡘ࠿ࡗࡓ⾑୰࣭౽୰ࣂ࢖࣐࣮࣮࢜࢝ࡣࣄࢺࢧࣥࣉࣝࢆ⏝࠸᳨࡚த᫬௦࡟✺ධࡋ࡚࠸ࡿࠋ᪂ࡓ࡞ㄆ▱⑕᪋⟇ࡢ኱⥘࡟ࡣ6%ࡢㄆ
ドࡍࡿࠋࣂ࢖࣐࣮࣮࡛࢜࢝࠺ࡘ⑓ᝈ⪅ࡸ㧗ࢫࢺࣞࢫ⪅ࡢ୍⩌ࢆྠᐃ࡛▱⑕ᝈ⪅ࡢⓎ⑕ࢆῶᑡࡉࡏࡿ࡜ࡢᨻᗓ┠ᶆࡀ┒ࡾ㎸ࡲࢀࡿணࡁࢀࡤࠊᢠ⅖⑕⸆࡟ࡼࡿ⮫ᗋ἞㦂ࢆィ⏬ࡍࡿࠋ࠺ࡘ⑓ண㜵ࡑࡋ࡚ㄆ▱ᐃ࡜࡞ࡗࡓࡀࠊADࡢ᰿἞⸆㛤Ⓨࡣ㡻᣸ࡋ࡚࠾ࡾࠊ┠ᶆ㐩ᡂ࡟ ⑕ண㜵࡜࠸࠺᪂ࡋ࠸ᴫᛕࢆษࡾ㛤ࡁࠊ᪂ࡓ࡞aOPCࡢᙺ๭ࢆ᫂ࡽ࠿࡟ࡍ
ࡣ௬ㄝࡢఱࡽ࠿ࡢぢ┤ࡋࡀᚲせ࡛࠶ࢁ࠺ࠋ
ࡿࠋᇵ㣴aOPCࢆ⏝࠸ࡓࢫࢡ࣮ࣜࢽࣥࢢ⣔ࢆ⏝࠸࡚᪂つAD᰿ᮏⓗ἞⒪(2)ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ *Tatebayashi Y, Kikuchi-Nihonmatsu N, Matsuda Y, Aoki K,
Uchihara T (2019) Essential roles of plexin-B3+
oligodendrocyte progenitor cells in the pathogenesis ofAlzhimer’s disease. Alzheimer Society International Congress(ASIC2019), Symposium invited. 2019.2.18~21. San Francisco,
USA.

(1)

ᴫせ
࠺ࡘ⑓ࡸ཮ᴟᛶ㞀ᐖ㸦㌄࠺ࡘ⑓㸧࡞࡝Ẽศ㞀ᐖࡣࠊ⢭⚄⛉ࢆ௦⾲ࡍࡿ⑌ᝈࡢ୍ࡘ࡛࠶ࡿࡀࠊᮍࡔᐈほⓗデ᩿ἲࡣ☜❧ࡉࢀ࡚࠾ࡽࡎࠊ἞⒪ἲࡶ༑ศ࡛ࡣ࡞࠸ࠋࢫࢺࣞࢫ࡞࡝ࡢ♫఍⎔ቃᅉᏊ࡟ࡼࡗ࡚ᝈ⪅ᩘࡣቑຍࡋࠊ࢔ࣝࢶࣁ࢖࣐࣮⑓㸦AD㸧
ࡢ༴㝤ᅉᏊ࡜ࡶࡉࢀࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ㸦㸯㸧࠺ࡘ⑓࡞࡝Ẽศ㞀ᐖࡢ⑓ែゎ᫂◊✲ࠊ㸦㸰㸧ᐈほⓗデ᩿ἲ࣭᪂つ἞⒪ἲ㛤Ⓨ◊✲ࠊ㸦㸱㸧࠺ࡘ⑓࡜ADࡢ㛵㐃◊✲ࢆ3ᮏᰕ࡜ࡋ࡚
ィ⏬ࢆᐇ᪋ࡋ࡚࠸ࡿࠋලయⓗ࡟ࡣࠊ㸯㸧Ṛᚋ⬻◊✲ࠊ㸰㸧ࣔࢹࣝື≀㛤Ⓨࠊ㸱㸧⎔ቃᅉᏊ◊✲ࠊ㸲㸧࢜ࣜࢦࢹࣥࢻࣟࢧ࢖
ࢺ๓㥑⣽⬊(௨ୗaOPCs࡜⥲⛠ࡍࡿ)ࡢᇶ♏◊✲࡜ࢫࢡ࣮ࣜࢽ
ࣥࢢ⣔ࡢ㛤Ⓨࠊ㸳㸧᪂つࣂ࢖࣐࣮࣮࢜࢝ࠊ἞⒪ἲࡢ⮫ᗋ἞㦂➼ࢆ⾜ࡗ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ

－ 25 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ(3) ᅜෆእࡢ◊✲≧ἣ
⑕౛ࢆฟⓎⅬ࡜ࡋ࡚⮫ᗋ᳨య᳨࣭ᰝᡤぢ࡟ᇶ࡙ࡃ◊✲ࢆ⾜࠸ࠊື≀╧╀◊✲ࢆ୪⾜ࡍࡿᙧࢆ࡜ࡿⅬࡀᮏࣉࣟࢪ࢙ࢡࢺࡢ≉ᚩ࡛࠶ࡿࠋࣜ
࣮ࢲ࣮⮬㌟ࡀᅜෆ᭱኱つᶍࡢ㐣╀⑕ᑓ㛛እ᮶࡛デ⒪࣭ᣦᑟࢆ⾜ࡗ࡚࠾ࡾࠊ⮫ᗋᛂ⏝࡟┤⤖ࡋࡓయไ࡛࠶ࡿࠋୡ⏺᭷ᩘࡢ㐣╀⑕DNA᳨యࢆࡶࡕࠊ㐣╀⑕ࡢDNA࣓ࢳࣝ໬◊✲ࢆୡ⏺࡟ඛ㥑ࡅ࡚㐍ࡵ࡚࠸ࡿࠋ╧╀ぬ㓰ࡢ⚄⤒ᶵᵓࡣ◊✲ࡀ㐍ᒎࡋ࡚࠸ࡿࡀ⚄⤒άືࢆᨭ࠼ࡿ௦
ㅰኚືࢆࣜ࢔ࣝࢱ࢖࣒࡛ᤊ࠼ࠊ╧╀ぬ㓰≧ែ࡟౫Ꮡࡋࡓኚ໬ࢆほᐹࡍࡿࡇ࡜ࡣ࡛ࡁ࡞࠿ࡗࡓࠋගࣇ࢓࢖ࣂ࣮ἲ࡛ࡢ⣽⬊ෆATPኚືほᐹࡣ╧╀ぬ㓰◊✲࡟᪂どⅬࢆࡶࡓࡽࡍࡶࡢ࡛࠶ࡿࠋ╧╀㞀ᐖ࡜Ⰻ㉁࡞
╀ࡾࡢゎ᫂࡟ࠊ╧╀ࡢ⑓⌮࡜⏕⌮ࡢ୧㠃࠿ࡽ࢔ࣉ࣮ࣟࢳࡍࡿࠋ

(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭Miygawa T et al (2018)A variant at 9q34.11 is associated with HLADQB1*06:02 negative essential hypersomnia. J Hum Genetics,
63(12):1259-1267.
࣭ Miyagawa T, Tokunaga K. (2019) Genetics of Narcolepsy. Hum
Genome Variation Jan 8;6:4 doi: 10.1038/s41439-018-0033-7
࣭Honda M, Ueno T, Wada M, Narisawa H, Ito W. (2018) Analysis ofsleep bout duration : A new marker to differentiate narcolepsy type 1㸬⡿ᅜ╧╀Ꮫ఍ 2018.6.3 Baltimore, MA U.S.A.
࣭ Natsubori A et al (2018) The intracellular ATP dynamics in the
cerebral cortex is closely related to the neurometabolic coupling, Sapporo
Symposium on Biological Rhythm in 2018, 2018.7.12 Sapporo,Japan(1) ᴫせ⌧௦♫఍࡛ࡣ⏕ά⩦័ࡸປാࡢ㉁ⓗኚ໬࠿ࡽ╧╀㞀ᐖࡀቑຍࠊᅜ
Ẹࡢ14.9%ࡀ៏ᛶⓗ╀Ẽࢆッ࠼ࠊຠ⋡పୗࡸ஦ᨾ࡟ࡘ࡞ࡀࡿㄆ▱ᶵ⬟㞀ᐖࢆࡁࡓࡍࠋࡲࡓ୰㏵ぬ㓰ᆺ୙╀ࡣຍ㱋ࡸ⑌ᝈ࡛ቑຍࡍࡿࡀࡑ
ࡢᇶ┙ࡣᮍゎ࡛᫂≉␗ⓗ἞⒪⸆ࡣᏑᅾࡋ࡞࠸ࠋᮏ◊✲࡛ࡣ᪥ᮏே࡟
ከ࠸㐣╀⑕࡛ࡢ╧╀ぬ㓰ไᚚ࡟ࡘ࠸࡚⑌ᝈ㛵㐃㑇ఏᏊࡢᶵ⬟᳨ウ࠿
ࡽ㏕ࡿ࡜࡜ࡶ࡟ࠊ╧╀᳨ᰝ(PSG)ࢆ⏝࠸ࡓ୰㏵ぬ㓰ࡢᣦᶆ᥈⣴࣭╧╀ࡢ㉁ホ౯ἲ㛤Ⓨࢆࡍࡍࡵࠊ୰㏵ぬ㓰ᆺ୙╀ࡢ⑓ែ⌮ゎࢆ⾜࠺ࡇ࡜ࠊࡑࡋ࡚ᇶ┙࡜࡞ࡿ╧╀ぬ㓰࡜⚄⤒⣽⬊ෆ࢚ࢿࣝࢠ࣮௦ㅰࡢ㛵㐃ࢆゎ᫂ࡋࠊデ᩿἞⒪࡜╧╀ᨵၿἲ࡜ࡋ࡚ࡢ㑏ඖࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ

㐣╀⑕ឤཷᛶ㑇ఏᏊࡢ᥈⣴ྠᐃ࡜ࡑࡢ⮫ᗋᛂ⏝㐣╀⑕㑇ఏᅉࡢ⮫ᗋ࣭ᶵ⬟㛵㐃ࢆ᫂ࡽ࠿࡟ࡍࡿࠋṚᚋ⬻ᚋ㒊どᗋୗ㒊⤌⧊ࢆ⏝࠸ࡓDNA࣓ࢳࣝ໬ゎᯒ࡟ࡘ࠸࡚ࠊࡑࡢሗ࿌ࢆ⾜࠺ࠋ⬻⬨㧊ᾮࢆ⏝࠸ࡓ௦ㅰ⏘≀(࣓ࢱ࣮࣒࣎ࣟ)ࢆྵࡵࡓ⤫ྜⓗ᳨ウ࠿ࡽࢼࣝࢥࣞࣉ
ࢩ࣮Ⓨ⑕ᶵᗎゎ᫂ࢆࡍࡍࡵࡿࠋ
PSGࡢ᪂つᣦᶆࡢ᳨ウࢆࡍࡍࡵࠊ╧╀ࡢ㉁ⓗホ౯ࠕ╧╀Ᏻᐃᛶࠖࡢ⮫ᗋᛂ⏝ࢆ┠ᣦࡍࠋ
኱⬻⓶㉁඲య࡛ࡣ࡞ࡃࠊ⣽⬊⭘≉␗ⓗ࡞ATP⃰ᗘኚືࢆ᳨ウࡋࠊ╧╀ぬ㓰୰ᯡ࡜኱⬻⓶㉁࡛ࡢATPኚືࡢ᫬⣔ิゎᯒࢆ㐍ࡵ࡚ࠊ╧╀ぬ㓰ࡢ࢚ࢿࣝࢠ࣮ᇶ┙ࢆ᫂ࡽ࠿࡟ࡍࡿࠋ

ձ

ճ

ղ

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼(2)

ճ ࢚ࢿࣝࢠ࣮௦ㅰ࠿ࡽࡳࡓ╧╀ぬ㓰ไᚚࡢᇶ┙◊✲࣭ ⣽⬊ෆATP⃰ᗘࢆ⺯ගࣉ࣮ࣟࣈ(GOATeam)࡛ឤ▱ࡍࡿ࣐࢘ࢫࢆ⏝࠸ࡓගࣇ࢓࢖ࣂ࣮ィ ࢩࢫࢸ࣒࡟ࡼࡾࠊATP⃰ᗘ࡜⬻⾑ὶ࠾ࡼࡧᒁᡤࣇ࢕࣮ࣝ
ࢻ㟁఩ࢆྠ᫬ ᐃࡋ᫬㛫ⓗ㛵㐃ࢆ᳨ウࡋࡓࠋ኱⬻⓶㉁࡛ࡢ⮬Ⓨⓗ⬻άື࡟ࡘ࠸࡚ࡣࠊ࣐࢞ࣥࣃ࣮࣡ቑຍᚋ࡟⣽⬊ෆATP⃰ᗘࡢ୍㐣ᛶపୗࡀ⏕ࡌࠊATP⃰ᗘపୗᚋ࡟ࢹࣝࢱࣃ್࣮࣡(῝╧╀ࡢᣦᶆ)ࡀቑຍࡋࡓࠋ኱⬻⓶㉁⣽⬊ෆ࢚ࢿࣝࢠ࣮≧ែࡀ╧╀ぬ㓰ไᚚ࡟㛵୚ࡍࡿྍ⬟ᛶࢆぢฟࡋࡓࠋղ 㐣╀⑕ᝈ⪅ࡢ⑕≧࣭デ᩿ࡢᐈほⓗᣦᶆࡢ㛤Ⓨ࣭ ୰㏵ぬ㓰ࡢ㉁ⓗホ౯࡜ࡋ࡚ࠊ╧╀࣏ࣜࢢࣛࣇ᳨ᰝ(PSG)࡛ࡢྛ╧╀ẁ㝵ࡢᏳᐃᛶ࡟ὀ┠ࠊࡦ࡜⥆ࡁࡢ╧╀ẁ㝵ࡢᣢ⥆᫬㛫(sleep bout duration)ࢆ
ホ౯ࡋࡓࠋ࣒ࣞ╧╀ẁ㝵ࡢᣢ⥆᫬㛫୰ኸ್ࡀ஺⤡ᅉᏊㄪᩚᚋ࡟ࡶࢼࣝࢥ
ࣞࣉࢩ࣮඾ᆺ౛ࡢ⊂❧ࡋࡓデ᩿ᣦᶆ࡜࡞ࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ╀Ẽࡣከඖᛶࢆࡶࡘࠋᚑ᮶⑓ⓗ╀Ẽࡢุᐃ(㐣╀⑕デ᩿)ࡣࠊධ╀ഴྥ(╀ࡾ ࡇ ࡳ ࡸ ࡍ ࡉ sleep propensity) ࡢ 㧗 ࡉ ࡛ ホ ౯ ࡉ ࢀ ࠊ ཯ ᚟ ╧ ╀ ₯ ᫬ ᳨ ᰝ(MSLT)ࢆgold standardࢆࡋ࡚ࡁࡓࠋࡋ࠿ࡋ㏆ᖺࢼࣝࢥࣞࣉࢩ࣮඾ᆺ౛௨
እࡢ⑕౛࡛ࡣ෌⌧ᛶࡀప࠸ㄢ㢟ࡀᣦ᦬ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣ⑓ⓗ╀Ẽࢆ⥲╧╀᫬㛫ᘏ㛗࡟ࡼࡗุ࡚ᐃࡍࡿ24᫬㛫PSGࢆ30వ౛࡛⾜࠸ࠊ≉Ⓨᛶ㐣╀⑕ࡢデ᩿࡟ࡣMSLTࡼࡾ24᫬㛫PSGࡀ᭷⏝࡛࠶ࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ≉Ⓨᛶ㐣╀⑕ࡣࢼࣝࢥࣞࣉࢩ࣮࡜୪ࡪ㐣╀⑕ࡢ௦⾲ࡔࡀࠊ␗✀ᛶࡢࡓࡵ◊✲ࡀ㐜ࢀ࡚࠸ࡿࠋᡃࠎࡣࡑࡢ㑇ఏᅉᏊ᥈⣴ࢆ㐍ࡵ⑌ᝈ㛵㐃㑇ఏᏊᗙࢆྠᐃࡋ
ࡓࠋࡲࡓࢤࣀ࣒࣡࢖ࢻ᭷ព࡞㛵㐃㑇ఏᏊࡣྠᐃ࡛ࡁ࡞࠿ࡗࡓࡀࠊⓎ⑕࡜㛵㐃ࡍࡿrare variantࢆ࢜ࣞ࢟ࢩࣥ๓㥑య㑇ఏᏊୖ࡟ྠᐃࡋሗ࿌୰࡛࠶ࡿࠋ࢜ࣞ࢟ࢩ
ࣥࡣࢼࣝࢥࣞࣉࢩ࣮௨እࡢ㐣╀⑕࡛ࡶ㛵㐃ࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ

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ᑠᒣ⣧ṇᮌᮧᫀ⏤⨾す㔝⢭἞ᐇ㦂⿵ຓဨ 㛵 ᗣᏊ
ᮏከⰾᏊ༠ຊ◊✲ဨ ᔱከ⨾✑Ꮚ
బ⸨ᬸኵᇶ┙ᢏ⾡◊✲ဨ ᑠᓥ ᓫ

ࢩࢽ࢔◊✲ဨඣ⋢ ஽(2) ◊✲⪅ྡ
ᐑᕝ ༟
ኟᇼ᫭ୡ

(1)

◊✲ᮇ㛫
2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

╧╀ぬ㓰ไᚚࡢゎ᫂࡜╧╀㞀ᐖࡢ἞⒪ἲ㛤Ⓨ㸭╧╀ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᮏከ ┿㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 26 －◊✲       ᡂ
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࣭ ADHD࠾ࡼࡧASDࡢ⑓ែ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࡀ㐍ࡳࠊᙜヱᏛၥ㡿ᇦ࡟ᑐࡋ࡚ࠊ᪂つ἞⒪ἲ࠾ࡼࡧண㜵ἲࡢᥦ᱌ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࠋ

⸆≀౫Ꮡ࡟㛵ࡋ࡚ࡣࠊ࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇ᇶᮏἲࠊ⤫ (2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ྜᆺࣜࢰ࣮ࢺ㸦IR㸧ᩚഛ᥎㐍ἲࠊࢠࣕࣥࣈࣝ➼౫Ꮡ⑕ᑐ⟇ᇶ ձ ⸆≀౫Ꮡ◊✲ᮏἲࡀ᪋⾜ࡉࢀࡓࡀࠊᅜෆ࡛ࡢ◊✲ࡣ୙༑ศ࡛࠶ࡿࠋᅜእ࡛ ࣭ ⸆≀౫ᏑࡢศᏊ࣓࢝ࢽࢬ࣒ࡀ᫂ࡽ࠿࡟࡞ࡾࠊ᪂ࡓ࡞἞⒪ἲࡸண㜵ἲࡢᥦ᱌ࡀ࡛ࡁࡿ࡜ᮇᚅࡉࢀࡿࠋ≉࡟ࠊぬࡏ࠸๣౫Ꮡᝈ⪅࡟࠾ࡅࡿ࢖ࡣ኱つᶍ࡞◊✲㈝ࡀᢞࡌࡽࢀ࡚࠸ࡿࡀࠊၥ㢟ゎỴ࡟ࡣ⮳ࡗ࡚ࣇ࢙ࣥࣉࣟࢪࣝࡢ⮫ᗋヨ㦂ࢆ㐍ࡵ࡚࠸ࡿࠋ᪤࡟㛤Ⓨࡋࡓ౫Ꮡ⑕≧ホ࠸࡞࠸ࠋ≉࡟ࠊ୰ᯡ่⃭⸆౫Ꮡ࡟ᑐࡍࡿ἞⒪⸆ࡣ࡞࠸ࠋಶู
౯ᑻᗘࡀᨵⰋࡉࢀࠊฮົᡤ࡞࡝ྛ✀ࡢᶵ㛵࡟࠾࠸࡚᭷ຠ฼⏝ࡉࢀࡿ
໬་⒪ࡢ㔜せᛶࡸᐇ⌧ᛶࡣୡ⏺ⓗ࡟㧗ࡲࡗ࡚࠸ࡿࡀࠊࢸ࣮ࣛ
ࡇ࡜࡛ࠊ⸆≀౫Ꮡၥ㢟ࡢ㍍ῶࡸ἞Ᏻࡢᨵၿ࡟⧅ࡀࡿ࡜ᮇᚅ࡛ࡁࡿࠋ
࣮࣓࢖ࢻ⑊③἞⒪ࡢ◊✲ࡣࠊᙜ◊✲ࢢ࣮ࣝࣉࡀୡ⏺ࢆ≌ᘬࡋղ 㙠③◊✲
࡚࠸ࡿࠋⓎ㐩㞀ᐖ◊✲࡟࠾࠸࡚ࡣࠊື≀ᐇ㦂࡜⮫ᗋ◊✲ࡣࡲ ࣭ ࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࡀ㛤ጞࡉࢀࡓࡢ࡛ࠊ௒ᚋࡣࡑࡢᨵⰋࡀᮇᚅ
ࡔ࡯࡜ࢇ࡝⤖ࡧࡘ࠸࡚࠸࡞࠸ࠋὀពḞዴከືᛶ㞀ᐖ(ADHD)἞
࡛ࡁࡿࠋࡲࡓࠊ⚄⤒㞀ᐖᛶ⑊③Ⓨ⑕⬤ᙅᛶ㛵㐃㑇ఏᏊከᆺࡢྠᐃࢆ⒪⸆ࡣ」ᩘㄆྍࡉࢀ࡚࠸ࡿࡀࠊ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕(ASD)ࡢ୰
㐍ࡵ࡚࠸ࡿࠋࡉࡽ࡟ࠊ࢜ࣆ࢜࢖ࢻㄏⓎᛶ჎Ẽ჎ྤࡢⓎ⑕⬤ᙅᛶ㛵㐃ᚰ⑕≧ࡢ἞⒪⸆ࡣୡ⏺ⓗ࡟ࡶࡲࡔ࡞ࡃࠊ◊✲㛤Ⓨࡀồࡵࡽࢀ㑇ఏᏊࢆぢฟࡍࠋ
ճ Ⓨ㐩㞀ᐖ◊✲࡚࠸ࡿࠋ(1)(2) ◊✲⪅ྡụ⏣࿴㝯ࠊ➟஭ៅஓࠊ⸨⏣㞞௦
ࠊす⃝኱㍜ࠊ஭ᡭ⪽୍㑻ࠊ኱ᒸ㟼⾰ࠊᒣᮏ⚽Ꮚࠊྂ⏣ᓥᾈᏊࠊⴗ㔝ὒᏊࠊ᳃ᒇ⏤⣖ࠊᒣす჆ᬕࠊ㟷ᮌㅬ඾ࠊኳ㔝ຌ஧㑻ࠊ᯽஭ὒᩥࠊ኱㇂ಖ࿴ࠊ㛗㇂ᕝ‽Ꮚࠊடࣨ㇂ᝋᏊࠊ୰ᒣிᏊࠊỤ⏿⿱Ꮚࠊᯇᓥ⏤⣖Ꮚࠊ⏣୰⨾ṌࠊṊ⏣ࢡ࣮ࣛࢡࠊ㧗ᶫ㤶ኸ㔛ࠊᯇ⃝┿ᙬࠊụ❑⤖Ꮚࠊᡂ⏣ ᚰࠊ⏣୰┿భ⨾ࠊሯᮏṇኴ㑻ࠊ஭ୖ⌮ᜨࠊᑠᓮⰾᙪࠊⴠྜ㑳⣖Ꮚࠊῧ⏣ ⴌࠊ⩏㑣᭷ᙬࠊᇼ Ᏻ⳯ࠊᮧᒸ Ώࠊబ⸨ᩔᚿࠊᒾ⏣ ೺ࠊཎཱྀᙬᏊࠊᑠᯘ኱㍜ࠊᖹ἟ᙬᏊࠊụ⏣᭸ᗈࠊྜྷỈᏕ⥴ࠊ⚄㎶ኴᶞࠊ㣤ᓥ㏻ᙪࠊ▼ሯᜤ⌮ࠊྜྷ⏣㤶⧊ࠊ୰ᮏⓒྜỤࠊ᳃㔝ⰋⶶࠊᏱ㔝ᜤ௓ࠊᴋ஭ඃ㤶ࠊᐑす⫕ࠊᶓᕝ┤ேࠊྜྷ⏣ Ⓩࠊబ⸨ⱥ᫂ࠊྂ⏣㡴Ꮚࠊᒣᮏ೺୍ࠊෆ
㔝ⱱኵࠊᑠᯘ ᚭࠊྜྷ஭ගಙࠊ
ᒣᮏᩄᩥࠊ᭮Ⰻ୍㑻ࠊᒾᶫ࿴ᙪ
ࠊᯘ⏣┾࿴ࠊᵽཱྀ 㐍ࠊ⚟⏣ㅬ୍ࠊጒᑿᰤ୍ࠊᱵ㔝 ඘ࠊ⤖ᇛఙὈ2015ᖺ4᭶䡚2020ᖺ3᭶
㸦5ᖺ㛫㸧

◊✲ᮇ㛫

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼


(1)

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎゎ᫂࡜ࡑࡢ་⒪ᛂ⏝㸭౫Ꮡᛶ⸆≀ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ụ⏣࿴㝯㸧(1) ᡂᯝࡢᴫせձ ⸆≀౫Ꮡ◊✲࣭ ࢔ࣝࢥ࣮ࣝ౫Ꮡᝈ⪅࡟࠾࠸࡚ࠊGIRKࢳࣕࢿࣝ㜼ᐖ⬟ࢆ᭷ࡍࡿ࢖ࣇ࢙
ࣥࣉࣟࢪࣝࡢ᭷ຠᛶࡀ♧ࡉࢀࡓࠋ࢜ࣞ࢟ࢩࣥཷᐜయ2㑇ఏᏊࡢ㠀ྠ⩏⨨᥮ከᆺࡀࠊࢽࢥࢳࣥ౫Ꮡ࡜㛵㐃ࡍࡿࡇ࡜ࢆࢤࣀ࣒࣡࢖ࢻ㛵㐃ゎᯒἲ࡟ࡼࡗ࡚ぢฟࡋࡓࠋ࢜ࣆ࢜࢖ࢻࢩࢫࢸ࣒࡜ࢻ࣮ࣃ࣑ࣥࢩࢫࢸ࣒ࡀ
␗࡞ࡿሗ㓘ࢆᢸ࠺ࡇ࡜ࢆ⬻ෆ⮬ᕫ่⃭ヨ㦂࡟ࡼࡾぢฟࡋࡓࠋղ 㙠③◊✲
࣭ ⑊③ឤཷᛶ࠾ࡼࡧ㙠③⸆ឤཷᛶ࡜㛵㐃ࡍࡿ㑇ఏᏊከᆺࢆከᩘぢฟࡋࡓࠋᵓ⠏ࡋࡓ㙠③⸆㐺㔞ண ᘧࢆ⏝࠸࡚ࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ࢆ
⥅⥆ࡋࡓࠋࡲࡓࠊᢠࡀࢇ๣ㄏⓎᮎᲈ⚄⤒㞀ᐖ⬤ᙅᛶ࡜㛵㐃ࡍࡿ㑇ఏ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼Ꮚከᆺࢆྠᐃࡋࡓࠋ
࣭ Ide, Ikeda, Biol Psychiatry, 2018
ճ Ⓨ㐩㞀ᐖ◊✲࣭ Nishizawa et al., Pharmacogenomics, 2018.
࣭ ࣂࣝࣉࣟ㓟ᢞ୚࣐࢘ࢫࡢASDᵝ⾜ືࡀࣛࣃ࣐࢖ࢩ࡛ࣥᨵၿࡍࡿࡇ࡜
࡞࡝ࠊཎⴭㄽᩥ35௳ࠊ⥲ㄝ➼28௳ࠊ⦅ⴭ7௳ࠊᏛ఍Ⓨ⾲࣭ㅮࡸࠊࢭࣟࢺࢽࣥࢺࣛࣥࢫ࣏࣮ࢱ࣮࣊ࢸࣟḞᦆ࣐࢘ࢫࡀASDᵝ⾜ືࢆ₇➼180௳㸦2015㸫2018ᖺᗘ㸧♧ࡋࢺࣜࣉࢺࣇ࢓ࣥḞஈ㣗ࡢᦤྲྀ࡛ᨵၿࡍࡿࡇ࡜ࢆぢฟࡋࠊASDࡢ⸆≀⒪ἲࡢ㛤Ⓨ࡟⤖ࡧࡘࡃᡂᯝࢆᚓࡓࠋ
(3) ᅜෆእࡢ◊✲≧ἣ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᴫせ౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎࢆゎ᫂ࡍࡿࡇ࡜࡛ࠊ౫Ꮡᛶ⸆≀ࡢ᭷ᐖᛶ࡜ࡋ࡚⸆≀౫Ꮡࡢ◊✲ࠊ᭷⏝ᛶ࡜ࡋ࡚㙠③࠾ࡼࡧⓎ㐩㞀ᐖࡢ◊✲ࢆ㐍ࡵࡓࠋලయⓗ࡟ࡣࠊࠕ⸆≀౫Ꮡ἞⒪ἲ࠾ࡼࡧண
㜵ἲࡢᥦ᱌ࠖࠊࠕࢸ࣮࣮࣓ࣛ࢖ࢻ⑊③἞⒪ἲࡢᐇ⌧ࠖࠊࠕ᪂つⓎ㐩㞀ᐖ἞⒪ἲࡢᥦ᱌ࠖ࡜࠸࠺ࠊ3ࡘࡢ᫂☜࡞♫఍㑏ඖ࡛ࣞ࣋ࣝࡢ┠ᶆࢆタᐃࡋࠊศᏊࣞ࣋ࣝࠊື≀ࣞ࣋ࣝࠊࣄࢺࣞ࣋
ࣝࠊ♫఍㑏ඖࣞ࣋ࣝࡢ◊✲ࢆ᭷ᶵⓗ࡟Ⓨᒎࡉࡏࡓࠋ

୺࡞◊✲ᡂᯝ

－ 27 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣ࢝ࣝࣃ࢖ࣥࢆྵࡴࢱࣥࣃࢡ㉁ศゎ⣔ࡣୡ⏺୰࡛άⓎ࡟◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿศ㔝࡛࠶ࡾࠊᵝࠎ࡞ࣄࢺ⑌ᝈࡢ἞⒪ᶆⓗ࡜ࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿࠋ࢝ࣝࣃ࢖ࣥ㑇ఏᏊኚ␗࡟ࡼࡿࣄࢺ⑌ᝈࡢ
◊✲࡜ࡋ࡚ࡣࠊ➽ࢪࢫࢺࣟࣇ࢕࣮ࠊ㣗㐨⅖ࠊ║⑌ᝈࡀୡ⏺ⓗ࡟┒ࢇ࡛࠶ࡿࠋᙜࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊᪧ㒔⮫ᗋ◊᫬௦ࡼࡾᨾ
㕥ᮌ⣫୍༤ኈ࣭ᨾ཯⏫ὒஅ༤ኈࡽࡀࡍࡍࡵ࡚ࡁࡓ⏕໬Ꮫⓗ࡞࢝ࣝࣃ࢖ࣥࡢ⏕⌮ᶵ⬟ゎᯒ࡜⑌ᝈࣔࢹ࡛ࣝࡢⓎ⑕ᶵᵓゎ᫂ࢆᇶ┙࡜ࡋࠊ➽ࢪࢫࢺࣟࣇ࢕࣮ࠊ⫶⭠⑌ᝈࠊ⓶⭵⑓࡞࡝ࢆ୰ᚰ
࡟デ᩿࣭἞⒪ࢆど㔝࡟ධࢀ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Nat Rev Drug Disc 15(2016) 854-76.
࣭ J Biol Chem 291(2016) 27313-22.
࣭ Mol Cell Proteomics 15(2016) 1262-80.
㸦௨ୗࡢᏛ఍࡟࠾࠸࡚ᡂᯝࢆⓎ⾲㸧
࣭ 2019ᖺᗘ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2019.3.24~27, ᮾி࣭ ➨1ᅇ᪂Ꮫ⾡ࢣࣔࣘࣅ࢟ࢳࣥ㡿ᇦ⌜఍㆟࣭➨2ᅇࣘࣅ࢟ࢳ
ࣥ◊✲఍ྜྠ఍㆟ 2019.1.14㹼1.16, ᮾி࣭ ࠕ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕࣮ Up to Dateࠖ2018.9.29㸪኱㜰࣭ ᪥ᮏ➽Ꮫ఍➨㸲ᅇᏛ⾡㞟఍ 2018.8.10, ᒸᒣ࣭ ᪥ᮏ⑓ែࣉࣟࢸ࢔࣮ࢮᏛ఍➨23ᅇ኱఍ 2018.8.3, ⏥ᗓ࣭ ➨31ᅇࣔࣟࢩࢾࢫ◊✲఍ࠊ2018.6.23㸪ᮐᖠ

(1)

ᴫせᣦ ᐃ㞴⑓ࡢ㑇ఏᛶ⑌ᝈ࡛ࠊ➽⫗࣭ ➽ ࢪࢫࢺࣟࣇ࢕࣮ࡣཌປ┬ᣦࡀ㐍⾜ᛶ࡟ⴎ⦰ࡋṚ࡟⮳ࡿ㞴⑓࡛࠶ࡿࠋࡲࡓࠊ⫶⭠⑌ᝈࡸ⓶⭵⑓࡞࡝ࡣ⌧௦♫♫఍࡟࠾࠸࡚ᙉ࠸㛵ᚰࢆ㞟ࡵࡿࠋ἞ ⒪࣭デ᩿ࡣࠊ♫఍ⓗ࡟኱ࡁ࡞ᚲ
ᚲ࣭ ࡑࡢࡓࡵࠊࡇࢀࡽ⑌ᝈࡢ἞
せᛶ࡜⥭⥭ᛴᛶࢆᣢࡕከ㠃ⓗ࡞࢔ࣉ࣮ࣟࢳࡀ㔜せ࡜࡞ࡿࠋ࢝ ࣝࣃ࢖࣭ ୖグ⑌ᝈࡢ୍㒊ࡣ⣽⬊ෆࢱࣥࣃࢡ㉁ษ᩿㓝⣲ࠕ࢝ࣥࠖࡢᶵᶵ⬟୙඲࡛Ⓨ⑕ࡍࡿࠋ⏕ ⌮ᶵ⬟࡜㛵㐃⑌ᝈࡢ࣭ ୙᫂࡞㒊ศࡢከ࠸ࠕ࢝ࣝࣃ࢖ࣥࠖࡢ⏕Ⓨ⑕ཎᅉ࣭ᶵᵓࢆゎ᫂ࡋࠊ἞἞⒪࣭デ᩿࡬ࡢᒎ㛤ࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ✲       ᡂ

E

ᯝ

A

㦵᱁➽࡟Ⓨ⌧ࡍࡿ࢝ࣝࣃ࢖ࣥ3㸦CAPN3㸧࣭ CAPN3ᶵ ⬟Ḟᦆ 㸦ࣀࣀ ࢵ ࢡ ࢖ࣥ (KI)ࠊࣀ
ࣀ ࢵ ࢡ ࢔ ࢘ ࢺ (KO)㸧 ࣐࢘ ࢫ ࡛ࡣࠊ➽ࢪࢫࢺࣟࣇ࢕࣮⑕≧ࡀ㢧ⴭ࡟࡞ࡿ௨๓ࡢ⏕⫱ึᮇ࡟ࠊ➽⧄⥔ᆺࡢᡂ⇍㐜ᘏࡀほᐹࡉࢀࡿࠋ࣭ ➽⣽⬊࡟Ꮡᅾࡍࡿ࢝ࣝࣃ࢖ࣥ3ࡣࠊࡇࢀࡲ࡛ᥦၐࡉࢀ࡚࠸ࡓ࣍ࣔ㸰㔞య࡛ࡣ࡞ࡃࠊ࣍ࣔ㸱㔞య࡜ࡋ᳨࡚ฟࡉࢀࡿࠋ
⫶⭠࡟Ⓨ⌧ࡍࡿG-࢝ࣝࣃ࢖ࣥ㸦CAPN8/CAPN9」ྜయ㸧࣭ CAPN8, CAPN9ࡢ㑇ఏᏊኚ␗ࡀ⑌ᝈⓎ⑕ࡢཎᅉೃ⿵࡛࠶ࡿ࡜࠸࠺ሗ࿌
ࢆࡶ࡜࡟ඹྠ◊✲ࢆ㛤ጞࡋࠊሗ࿌ࡉࢀࡓኚ␗ࡀG-࢝ࣝࣃ࢖ࣥࡢάᛶ
పୗࢆᘬࡁ㉳ࡇࡍྍ⬟ᛶࢆぢฟࡋࡓࠋ࣭ G-࢝ࣝࣃ࢖ࣥࡣ⫶⭠௨እࡢ⤌⧊࡟ࡶⓎ⌧ࡍࡿྍ⬟ᛶࡀ࠶ࡿࠋ
ࡑࡢ௚ࡢ࢝ࣝࣃ࢖ࣥ࡟ࡘ࠸࡚࣭ ᫖ᖺᗘ࡟࢙࢘ࣈୖ࡛බ㛤ࡋࡓ࢝ࣝࣃ࢖ࣥ-1ཬࡧ࢝ࣝࣃ࢖ࣥ-2࡟ࡼࡿษษ᩿㒊఩ண ჾࢆᨵゞࡋࠊ᪂ࡋ࠸ண ࢔ࣝࢦࣜࢬ࣒ࢆ௜ຍࡍࡿ࡜࡜ࡶ
࡟ࡼࡾ౑࠸ࡸࡍ࠸ࢹࢨ࢖ࣥࢆ᭦᪂ࡋࡓࠋ࣭ ࢝ࣝࣃ࢖ࣥ15ࡢᇶ㉁ೃ⿵ࢱࣥࣃࢡ㉁ࢆྠᐃࡋࠊࡑࡢάᛶḞᦆ࣐࢘ࢫࡢゎᯒ࡟ࡼࡗ࡚ᙧᡂ␗ᖖ࡬ࡢ㛵୚ࢆྠᐃࡋࡓࠋ࣭ ࢝ࣝࣃ࢖ࣥ10cDNA⏘≀ࡀ♧ࡍ␗ᖖ࡞ࢫࣉࣛ࢖ࢩࣥࢢࢆᢚไࡋࡓⓎ⌧ࢥࣥࢫࢺࣛࢡࢺࡢ฼⏝࡟ࡼࡾࠊ࢜ࣜࢦ࣐࣮ᙧᡂࢆྠᐃࡋࡓࠋ
(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼௒ᅇ᫂ࡽ࠿࡟ࡋࡓ࢝ࣝࣃ࢖ࣥࡢᵝࠎ࡞┦஫స⏝ᙧᘧࢆ⪃៖ࡋࠊྛ࢝
ࣝࣃ࢖ࣥࡢ㑇ఏᏊᨵኚ࣐࢘ࢫࡢ⾲⌧ᆺゎᯒࢆࡍࡍࡵࡿࠋ⌧ᅾࠊ་Ꮫ◊࡟ᑟධࡉࢀ࡚࠸ࡿᵝࠎ࡞ࢩࢫࢸ࣒㸦ࢱࣥࣃࢡ㉁ཬࡧ㑇ఏᏊⓎ⌧ࡸࠊ⣽⬊ᙧែࡢゎᯒࢶ࣮ࣝ㸧ࢆ✚ᴟⓗ࡟ά⏝ࡋࠊඹྠ◊✲ࡢᶵ఍ࢆᗈࡆ࡚㎿㏿࠿ࡘⓗ☜࡟ࢹ࣮ࢱゎ㔘ࢆ⾜࠺ࠋ࢝ࣝࣃ࢖ࣥ୙඲࡟ࡼࡿ⑌ᝈࡢⓎ⑕ᶵᵓࡀศᏊ࡛ࣞ࣋ࣝ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡜ࠊࡑࡢ⤖ᯝࢆࡶ࡜࡟⑌
⑌ ᝈࡢデ᩿
࣭἞⒪࡟᫂☜࡞᪉ྥᛶࢆ♧ࡍࡇ࡜ࢆ┠ᣦࡍࠋ

U

U

U

E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
㸦ᐈဨ◊✲ဨ㸧኱ᾏ ᚸ཯⏫඾Ꮚ㸦༠ຊ◊✲ဨ㸧
♞Ἴ୍ኵ
ᑿᔱᏕ୍
ᒣᮏ ᆂ

㸦◊✲⿵ຓ㸧
ᅵ஭ዉ✑Ꮚ❧㔝⋹Ꮚ
ୖᒸᑑᏊ**㇂ཱྀ㭯௦(2) ◊✲⪅ྡ
ᑠ㔝ᘺᏊ
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኱ෆྐᏊ
㔝ཱྀ࠶ࡸ*

2018ᖺ7᭶㹼2019ᖺ3᭶
㸦9ࣨ᭶㛫㸧*2018ᖺ4᭶㹼2018ᖺ9᭶㸦6ࣨ᭶㛫㸧**(1) ◊✲ᮇ㛫(1) ᡂᯝࡢᴫせ➽ࢪࢫࢺࣟࣇ࢕࣮ཬࡧ⫶⭠⑌ᝈ࡜࢝ࣝࣃ࢖ࣥ࡜ࡢ㛵ಀ࡟ຍ࠼࡚ࠊ࢝ࣝ 2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧ࣃ࢖ࣥࡢ᪂ࡓ࡞ไᚚᶵᵓࢆ♧၀ࡍࡿ▱ぢࢆᚓࡓࠋ◊࢝ࣝࣃ࢖ࣥᶵ⬟୙඲࡟ࡼࡿ⑌ᝈࡢⓎ⑕ศᏊᶵᵓࡢゎ᫂㸭࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᑠ㔝ᘺᏊ㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 28 －◊✲       ᡂ

E

ᯝ


(1)

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼


ᕝ⬥⣧Ꮚ
㧗ᶫࡕ࠿ࡆ
㸦◊✲⿵ຓဨ㸧

ᑠᓥ࿴⳹
Ᏹ⏣ᕝᬛ㔛
ᯘ⏣෽ử
㸦◊ಟ⏕㸧

(2) ◊✲⪅ྡ
ᯇ⏣᠇அ
ྜྷ⏣㞷Ꮚ
ᒣ㔝᫭ྐ
ᑠ㇂㔝ྐ㤶
㸦ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺࢫࢱࢵࣇ㸧(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾࣘࣅ࢟ࢳࣥࢩࢫࢸ࣒ࡢ␗ᖖ࡜⑌⑓㸭ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᯇ⏣᠇அ㸧(1) ᡂᯝࡢᴫせ࣭ ࣑ࢺࢥࣥࢻࣜ࢔ࡢရ㉁⟶⌮ࡣࠊ⏕ᾭྠࡌ⣽⬊ࢆ౑࠸⥆ࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸⚄⤒⤌⧊ࡢ⥔ᣢ࡟ᚲ㡲࡛࠶ࡾࠊᵝࠎ࡞⚄⤒ኚᛶ
⑌ᝈࡢⓎ⑕ᶵᵓࢆ⪃࠼ࡿୖ࡛ࡶᴟࡵ࡚㔜せ࡞▱ぢ࡛࠶ࡿࠋ࣭ ᡃ ࠎ ࡣ 㑇 ఏ ᛶ ຎ ᛶ ࣃ ࣮ ࢟ ࣥ ࢯ ࣥ ⑓ (PD) ࡢ ཎ ᅉ ᅉ Ꮚ ࡛ ࠶ ࡿ
PINK1(ࢱࣥࣃࢡ㉁ࣜࣥ㓟໬㓝⣲)࡜Parkin(ࣘࣅ࢟ࢳࣥ㐃⤖㓝⣲)ࡀࣘࣅ࢟ࢳࣥ໬ࢆ௓ࡋ࡚࣑ࢺࢥࣥࢻࣜ࢔ရ㉁⟶⌮ࢆᢸ࠺ࡇ࡜
ࢆሗ࿌ࡋ࡚ࡁࡓࠋ
࣭ 2014ᖺࠥ2016ᖺ࡟࠿ࡅ࡚ࠊᡃࠎࡣPINK1ࡢᇶ㉁ࡀࣘࣅ࢟ࢳࣥ
࡛࠶ࡾࠊࣜࣥ㓟໬ࣘࣅ࢟ࢳࣥ㙐ࡀParkinࡢάᛶ໬ᅉᏊවࣞࢭࣉ
ࢱ࣮࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟(Nature, 2014, JCB,
2015)ࠊPINK1ࡸParkin࡜ࡣ␗࡞ࡿPDࡢཎᅉ㑇ఏᏊ⏘≀DJ-1ࡢ
(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ࣘࢽ࣮ࢡ࡞࣑ࢺࢥࣥࢻࣜ࢔ᒁᅾᶵᵓࢆሗ࿌ࡋࡓ(Genes
Cells,
࣭ Proc Natl Acad Sci 2017ᖺ2016)ࠋ2017ᖺ࡟ࡣࠊࣘࣅ࢟ࢳࣥ໬ࢆ௓ࡋࡓ᪂ࡓ࡞ࣜࢯࢯ࣮࣒
࣭ Sci. Rep., 2017ᖺศゎᶵᵓࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟(ྜྷ⏣ PNAS 2017)ࠊDJ-1ࡢ
࣭ eLife, 2018ᖺ≉Ṧ࡞࢔ࣝࢹࣄࢻゎẘᶵ⬟ࢆሗ࿌ࡋࡓ(ᯇ⏣ Sci. Rep. 2017)ࠋ
࣭ EMBO Workshop 2017ᖺ࣭ ᮏᖺᗘ(2018ᖺᗘ)࡟ࡣࠊPINK1ࡸParkinࡀ Rab-type పศᏊ㔞
࣭ Int. Prot. Metabo. Dise. Conf. 2017ᖺ
GTPase࡜༠ຊࡋ࡚ࠊ␗ᖖ࣑ࢺࢥࣥࢻࣜ࢔ศゎࡢࡓࡵ࡟ᚲせ࡞࣭ Keystone Symposium [joint sympo. of Mitochondrial Biology⭷ࢆࢧࣉࣛ࢖ࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡓ (ᒣ㔝 eLife 2018)ࠋ
(Z1) and Selective Autophagy (Z2)], 2018ᖺ࣭ ➨ 91ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2018ᖺᗘ⏕໬Ꮫ఍ዡບ㈹(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼
ཷ㈹ㅮ₇, 2018ᖺ࣭ Parkin ࡢ ᇶ ㉁ ≉ ␗ ᛶ ࢆ Ỵ ᐃ ࡍ ࡿ せ ᅉ ࢆ ㄪ ࡭ ࡿ ࡜ ࡜ ࡶ ࡟ ࠊ
Positive-feedback model ࡟࠾ࡅࡿ͆seed͇ࣘࣅ࢟ࢳࣥࡀ࡝ࡢࡼ
(3) ᅜෆእࡢ◊✲≧ἣ࠺࡟౪⤥ࡉࢀࡿࡢ࠿ࢆゎ᫂ࡍࡿࠋࣘࣅ࢟ࢳࣥ㛵㐃ᅉᏊࠊ≉࡟ࣘࣅ࢟ࢳࣥ࢟ࢼ࣮ࢮ PINK1 ࡜
࣭ PARKINࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆ⏝࠸࡚ࣃ࣮࢟ࣥࢯࣥ⑓ࣔࢹ࣐ࣝ
ࣘࣅ࢟ࢳࣥ㐃⤖㓝⣲ Parkin ࡢ◊✲ࡣᅜෆእ࡛⃭ࡋࡃ➇ྜࡋ࢘ࢫࢆ☜❧ࡋࠊParkinࡢゐ፹ࡍࡿࣘࣅ࢟ࢳࣥ໬ࡢ⏕⌮ⓗព⩏ࢆ࡚࠸ࡿ≧ἣࡔࡀࠊศᏊ⏕≀Ꮫ࣭⏕໬Ꮫ㡿ᇦ࡛ࡣ᭱ඛ➃◊✲ࢆin vivo࡛ࣞ࣋ࣝゎ᫂ࡍࡿࠋᒎ㛤ࡋ࡚࠸ࡿࠋDJ-1࡟ࡘ࠸࡚ࡣࠕ࢔ࣝࢹࣄࢻ௦ㅰ࡜ࣃ࣮࢟ࣥ
࣭⏕໬Ꮫ࣭⣽⬊⏕≀Ꮫ࣭㑇ఏᏛࡢᡭἲࢆ㥑౑ࡋ࡚ࠊDJ-1ࡢศᏊࢯࣥ⑓ࠖ࡜࠸࠺⊂⮬ࡢษࡾཱྀ࡛◊✲ࢆ⥆ࡅ࡚࠸ࡿࠋᶵ⬟ ࡜࣑ࢺࢥࣥ ࢻࣜ࢔ရ㉁⟶ ⌮࡟࠾ࡅࡿ ᙺ๭ࢆ᫂ࡽ࠿ ࡟ࡍࡿࠋ◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡᴫせࣘࣅ࢟ࢳࣥࢩࢫࢸ࣒ࡢ◚⥢ࡀᵝࠎ࡞⑌ᝈࢆᘬࡁ㉳ࡇࡍࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࡘࡘ࠶ࡿࡀࠊࡑࡢ⑓ែⓎ⑕࣓࢝ࢽࢬ࣒ࡣᮍࡔ
ከࡃࡢㅦ࡟ໟࡲࢀ࡚࠸ࡿࠋᡃࠎࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ␗ᖖ࣑ࢺ
ࢥࣥࢻࣜ࢔࡟ᑐࡍࡿࣘࣅ࢟ࢳࣥಟ㣭ࡀPINK1㑇ఏᏊኚ␗ࡸ
PARKIN㑇ఏᏊኚ␗࡜㛵㐃ࡍࡿ㑇ఏᛶࣃ࣮࢟ࣥࢯࣥ⑓ࡢⓎ⑕ᢚไ࡟㔜せ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࠊࡑࡢศᏊᶵᵓ࠾ࡼࡧ⑓ែ⏕⌮ⓗព⩏ࡢゎ᫂ࢆ⾜࡞ࡗ࡚ࡁࡓࠋࡲࡓࠊDJ-1㑇ఏᏊኚ␗࡟⏤᮶ࡍࡿ␗࡞ࡿࢱ࢖ࣉࡢ㑇ఏᛶࣃ࣮࢟ࣥࢯࣥ⑓࡟ࡘ࠸࡚ࡶࠊࡑࡢ
Ⓨ⑕ᶵᵓࢆゎᯒࡋ࡚࠸ࡿࠋ

୺࡞◊✲ᡂᯝ

－ 29 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

(3)

ᅜෆእࡢ◊✲≧ἣࣄࢺiPS⣽⬊ࢆ⏝࠸ࡓ⾑ᾮ෌⏕་⒪࡟ࡘ࠸࡚ࡣࠊᕧ᰾⌫๓㥑⣽⬊ᰴࢆ⏝࠸ࡓ⾑ᑠᯈ〇㐀ࡀᐇ⏝໬࡟ྥ࠿ࡗ࡚࠸ࡿࡀࠊ㐀⾑ᖿ⣽⬊࡟ࡘ࠸࡚ࡣࡲࡔᡂຌࡋ࡚࠸࡞࠸ࠋḟ࡟ࠊᛴᛶTࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓(T-ALL)࡟ᑐࡍࡿ἞⒪⸆࡜ࡋ࡚ࡣࠊḢ⡿࡟࡚
MYCࡢάᛶ㜼ᐖ๣➼ࡢ⮫ᗋヨ㦂ࡀ⾜ࢃࢀ࡚࠸ࡿࠋ᭱ᚋ࡟ࠊCXCL14㛵㐃࡛ࡣCXCL12-CXCR4㍈ࢆᶆⓗ࡜ࡍࡿPlerixaforࡀㄆྍࡉࢀ࡚࠸ࡿࡀࠊࢣࣔ࢝࢖ࣥࢆ฼⏝ࡋࡓ⒴ච␿⒪ἲࡣ๓౛
ࡀ࡞࠸ࠋ

(2)

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Exp. Hematol., 44: 68-74, 2016.
࣭ Biochem. Biophys. Res. Commun., 474: 462-468, 2016.
࣭ PLoS ONE, 11: e0157187, 2016.
࣭ Genes Cells, 22: 71-83, 2017.
࣭ EBioMedicine, 24: 247-256, 2017.
࣭ Biochem. Biophys. Res. Commun., 495: 2310-2316, 2018.
࣭ Cancer Sci., 109: 2479-2489, 2018.
࣭ Genes Cells, 23: 753-766, 2018.
࣭ Int. J. Dev. Biol., 63: 29-35, 2019.
࣭ Biochem. Biophys. Res. Commun., 512: 399-404, 2019.

(1)

ᴫせ㐀⾑ᖿ⣽⬊ࡣࠊࡍ࡭࡚ࡢච␿ᢸᙜ⣽⬊ࢆ⏘ࡳฟࡋ࡚ࡃࢀࡿࠊ
⏕య࡟ᚲ㡲࡞⣽⬊࡛࠶ࡿࠋ೺ᖖேࡸᝈ⪅ࡢiPS⣽⬊ᰴ࠿ࡽࠊ㐀⾑ᖿ⣽⬊࣭⾑ᑠᯈ࣭⣽⬊㞀ᐖᛶT⣽⬊ࢆศ໬ㄏᑟ࡛ࡁࡿࡼ࠺
࡟࡞ࢀࡤࠊ⾑ᾮ㛵㐃㞴⑓࡟ᑐࡍࡿ἞⒪ἲࡢ㑅ᢥ⫥ࡀ኱ᖜ࡟ᗈ
ࡀࡿ࡜ᮇᚅࡉࢀࡿࠋ୍᪉ࠊṚஸ⋡㸯఩ࡢ ࡀࢇඞ᭹࡟ྥࡅ࡚
ࡣࠊᖿ⣽⬊㛵㐃ศᏊࢆᶆⓗ࡜ࡍࡿᢠࡀࢇ๣ࡀὀ┠ࡉࢀ࡚࠸ࡿࠋ
ᮏ◊✲࡛ࡣࠊࣄࢺiPS⣽⬊࠿ࡽᶵ⬟ⓗ࡞⾑ᾮ⣽⬊ࢆ ຠ⋡ⓗ࡟సࡾฟࡍ᪉ἲࠊ୪ࡧ࡟᪂ࡋ࠸ࡀࢇ἞⒪ἲ࣭デ᩿ἲࡢ㛤Ⓨ࡟ᣮࡴࠋ୺࡞◊✲ᡂᯝ✲       ᡂ

E

ᯝ


(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ࣄࢺiPS⣽⬊ࢆ⏝࠸ࡓ⾑ᾮ෌⏕◊✲࡛ࡣࠊ㐀⾑ศ໬ㄏᑟࣉࣟࢺࢥ
࣮ࣝ࡜⣽⬊ᰴࡢ᭱㐺໬ࡀ᏶஢ࡋࡓࡢ࡛ࠊLhx2ᨵኚయࡸ࣐࢘ࢫAGM㡿ᇦඹᇵ㣴⣔➼ࢆ฼⏝ࡋ࡚ࠊ㐀⾑ᖿ⣽⬊ࡢin vitroศ໬ㄏᑟࢆヨࡳࡿࠋḟ࡟ࠊT-ALL἞⒪⸆࡟ࡘ࠸࡚ࡣࠊྜᡂᒎ㛤◊✲ࢆ⥆⾜ࡋ࡚ࡼࡾඃࢀࡓ໬ྜ≀ࢆ๰ฟࡍࡿ࡜࡜ࡶ࡟ࠊື≀ࣔࢹࣝࢆ⏝࠸࡚in vivo࡛ࡢ᭷ຠᛶࢆ᳨ドࡍࡿࠋ᭱ᚋ࡟ࠊCXCL14࡟ࡼࡿ㐺ᛂච␿⣔ࡢ㈿ά໬ࡣࠊᏛ⾡࣭ᛂ⏝ࡢ୧㠃࠿ࡽ⏬ᮇⓗ࡞◊✲ᡂᯝ࡛࠶ࡿࠋDNAㄆ㆑ࡢᵓ㐀ⓗᇶ┙ࡸཷᐜయࡢゎ᫂ࢆ㐍ࡵࡿ࡜ྠ᫬࡟ࠊ⒴ච␿ࢆᙉ໬
ࡍࡿCpG DNA/CXCL14」ྜయ࢔ࢪࣗࣂࣥࢺࡢ㛤Ⓨ࡟ᣮᡓࡋ࡚࠸
ࡃࠋ᭱ᚋ࡟ࠊ㒔ࡢ≉ู◊✲㈝ࡢᨭ᥼ࢆཷࡅ࡚ᐇ᪋ࡋࡓDiAcSpm⒴デ᩿ἲࡢ㛤Ⓨ࡟ࡘ࠸࡚ࡣࠊ࡜࡚ࡶ᭷ᮃ࡞⤖ᯝࡀᚓࡽࢀ࡚࠾ࡾࠊヨ
⸆㈍኎࡟ྥࡅ࡚௻ᴗࡢ἞㦂◊✲ࡀᐇ᪋ࡉࢀ࡚࠸ࡿ᭱୰࡛࠶ࡿࠋᡂᯝࡢᴫせ᪤ᏑࡢࣄࢺiPS⣽⬊ࡢศ໬ㄏᑟἲࡣ㐀⾑⣔ࡢㄏᑟຠ⋡ࡀప࠸ࡓࡵࠊࣉࣟࢺࢥ࣮ࣝࡢᨵⰋ࡟ྲྀࡾ⤌ࢇࡔࠋࡑࡢ⤖ᯝࠊศ໬ㄏᑟ㛤ጞ0-1᪥┠࡟GSK3E㜼ᐖ๣ࢆῧຍࡍࡿ࡜ศ໬ㄏᑟ⋡ࡀ๻ⓗ࡟㧗ࡲࡿࡇ࡜ࢆⓎぢࡋࡓࠋGSK3E㜼ᐖ๣ࡢ୍㐣ⓗ࡞ฎ⌮࡟ࡼࡗ࡚ࠊ⬇
ࡢᚋ᪉໬ࢆಁࡍWNT/E-CATENIN⤒㊰ࡀάᛶ໬ࡉࢀࠊ㐀⾑Ⓨ⏕࡟ᚲ㡲࡞CDX/HOX㑇ఏᏊ⩌ࡀ㌿෗ㄏᑟࡉࢀࡿࡼ࠺࡟࡞ࡗࡓࠋḟ
࡟ࠊࣄࢺT-ALL⣽⬊ᰴࡢቑṪࢆ≉␗ⓗ࡟ᢚไࡍࡿኳ↛໬ྜ≀
31D-F005ࢆྠᐃࡋࠊࡑࢀࡀT-ALLᝈ⪅⏤᮶ࡢึ௦ⓑ⾑⑓⣽⬊ࡢቑṪࡶᢚไ࡛ࡁࡿࡇ࡜ࢆド᫂ࡋࡓࠋࡉࡽ࡟ᮏ≀㉁ࡢྜᡂᒎ㛤◊✲࡟ࡼࡗ࡚ࠊ31D-F005ࡼࡾඃࢀࡓᢠࡀࢇάᛶࢆ᭷ࡍࡿపศᏊ໬
ྜ≀ࡢ᭷ᶵྜᡂ࡟ᡂຌࡋࡓ㸦≉チฟ㢪2018-90192㸧ࠋ᭱ᚋ࡟ࠊCXCL14ࡀCpG DNA࡟㧗ぶ࿴ᛶ⤖ྜࡋࠊࡑࢀࢆᶞ≧⣽⬊ෆ࡬㐠ࡧ㎸ࡴࡇ࡜࡛TLR9ࢆ௓ࡋࡓ㐺ᛂච␿⣔ࢆάᛶ໬ࡍࡿࡇ࡜ࢆⓎぢࡋࡓ㸦≉チฟ㢪2016-091183㸧ࠋCXCL14-KO࣐࢘ࢫࡣࠊ࣓ࣛࣀ
࣮࣐࡜≉ᐃࡢ⣽⳦ឤᰁ࡟㧗ឤཷᛶ࡛࠶ࡗࡓࠋࡉࡽ࡟ࠊCpG DNACXCL14ཷᐜయೃ⿵ศᏊࡢྠᐃ࡟ᡂຌࡋࡓࠋ
(1)

A

◊


E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ◊✲⪅ྡ
ཎ Ꮥᙪ
໭ᓥ೺஧
✀Ꮚᓥᖾ♸
㕥ᮌ㍤ᙪ
ᮧᒸṇᩄ
ᖹᯇᜤᏊ

(1) ◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

ᖿ⣽⬊ࢆ฼⏝ࡋࡓ⾑ᾮ෌⏕་⒪ᢏ⾡࡜ࡀࢇ἞⒪ἲࡢ㛤Ⓨ㸭ᖿ⣽⬊ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ཎ Ꮥᙪ㸧㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ－ 30 －

◊  ✲  ෆ  ᐜ㸦◊✲௦⾲⪅ྡ㸧

◊✲ㄢ㢟ྡ

E

◊
       ✲       ᡂ       ᯝ




◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
ඹྠ◊✲⪅Bruce Conklin(Gladstone Institutes, USA)
Nathan Salomonis(Cincinnati Children's
Hospital, USA)(2) ◊✲⪅ྡ
ᐑᒸభ୍㑻
ຍ⸨᭸Ꮚ
㧗ᶫ ๛
チ ⤬ⲓ

(1)

◊✲ᮇ㛫
2016ᖺ4᭶㹼2020ᖺ3᭶
㸦4ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ
iPS⣽⬊ࡢࢤࣀ࣒⦅㞟࡟ࡼࡿ⑌ᝈࡢ἞⒪ἲࡢ㛤Ⓨ㸭෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ᐑᒸభ୍㑻㸧(1) ᡂᯝࡢᴫせ࣭ Cas9࡜DNAࡢ㛫ࡢ┦஫స⏝ᵝᘧ࡟ᙳ㡪ࢆཬࡰࡍCas9ࡢⅬኚ␗ࡸࠊ࢞࢖
ࢻRNAࡢ㛗ࡉࡢ┦㐪ࡀࠊ୍ሷᇶ⨨᥮࡟ຍ࠼࡚ࠊᩘ༓ሷᇶᑐࡢDNA᩿
∦ࡢࣀࢵࢡ࢖ࣥ࡟㛵ࡋ࡚ࡶࠊ⤌᥮࠼ࢆ௓ࡋࡓࢤࣀ࣒⦅㞟ࡢຠ⋡࡟኱ࡁ࡞ᙳ㡪ࢆ୚࠼ࡿࡇ࡜ࢆぢฟࡋࡓࠋ࣭ ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⏝࠸࡚ࠊ೺ᖖ⪅⏤᮶iPS⣽⬊࡟ᚰ➽⑕ࡢཎᅉ࡜࡞ࡿ
RBM20࡜࠸࠺㑇ఏᏊࡢኚ␗ࢆᑟධࡋࠊࡑࡢ⣽⬊ࢆᚰ➽⣽⬊࡬࡜ศ໬ㄏᑟࡋࡓࠋࡇࢀࡽiPS⣽⬊⏤᮶ᚰ➽⣽⬊ࡢ㌿෗⏘≀ࢆḟୡ௦ࢩ࣮ࢡ࢚
ࣥࢫ࡟ࡼࡾ⥙⨶ⓗ࡟ゎᯒࡍࡿࡇ࡜࡛ࠊRBM20ࡢኚ␗ࡀ㑇ఏᏊⓎ⌧࠾ࡼࡧࢫࣉࣛ࢖ࢩࣥࢢᵝᘧ࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊ(2) ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼
RBM20ࡢኚ␗ࡣᚰ➽⣽⬊ࡢ㑇ఏᏊⓎ⌧ᵝᘧࡸࢫࣉࣛ࢖ࢩࣥࢢᵝᘧࢆࠊᮍ⇍࡞≧ែ࡟࡜࡝ࡵ࡚ࡋࡲ࠺࡜࠸࠺ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡉࡽ
ཎⴭㄽᩥ࣭⥲ㄝ
࡟ࠊRBM20ࡣᮏ᮶᰾ෆ࡟ᒁᅾࡍࡿࡀࠊኚ␗ࢱࣥࣃࢡ㉁ࡣ⣽⬊እ࡛ࢱ࣭ Kato-Inui T, Takahashi G, Hsu S, Miyaoka Y. Clusteredࣥࣃࢡ㉁จ㞟యᵝࡢᵓ㐀ࢆᙧᡂࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡇ࠺ࡋࡓኚ
regularly
interspaced
shortpalindromic
repeats(CRISPR)/CRISPR-associated protein 9 with improved proof␗ࡣ㢧ᛶⓗ࡟ࡣࡓࡽࡁࠊ࣊ࢸࣟࡢ⣽⬊࡛ࡶṇᖖ࡞RBM20ࡢᶵ⬟ࢆ㜼
reading enhances homology-directed repair. Nucleic Acidsᐖࡍࡿࡇ࡜ࡶぢฟࡋࡓࠋRBM20ኚ␗ࢆ࣊ࢸ࡛ࣟᣢࡘᝈ⪅ࡀᚰ➽⑕ࢆResearch 46:4677-4688, 2018
Ⓨ⑕ࡍࡿཎᅉ࡜⪃࠼ࡽࢀࡿࠋ
࣭ Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR. Detection and ࣭ 㑇ఏᛶ⫢⑌ᝈ࡛࠶ࡿ࢘࢕ࣝࢯࣥ⑓ࡢᝈ⪅⏤᮶iPS⣽⬊ࡀᣢࡘࠊཎᅉኚ
Quantification of HDR and NHEJ induced by genome editing
␗ࡢATP7B࡜࠸࠺㑇ఏᏊࡢR778LⅬኚ␗ࢆಟṇࡋࠊ⑌ᝈࣔࢹࣝ☜❧ࡢat endogenous gene loci using Droplet Digital PCR. Methodsࡓࡵࡇࢀࡽࡢ⣽⬊ࢆ⫢⮚ࡢ⣽⬊࡬࡜ศ໬ࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓࠋࡇ
in Molecular Biology 1768:349-362, 2018
ࢀࡽiPS⣽⬊⏤᮶⫢⣽⬊࡟࠾ࡅࡿATP7Bࡢ⣽⬊ෆᒁᅾࢆほᐹࡋࡓ࡜ࡇ࣭ ᐑᒸభ୍㑻 ୍ሷᇶ⨨᥮࡟ࡼࡿ⑌ᝈࣔࢹࣝ⣽⬊స〇 ᭶
ࢁࠊኚ␗ATP7Bࢱࣥࣃࢡ㉁ࡢⓎ⌧㔞ࡀపୗࡋࠊࡉࡽ࡟ᮏ᮶ᒁᅾࡍࡿ
หࠕ⣽⬊ࠖ 2019ᖺ3᭶ྕࢦࣝࢪయ࠿ࡽࡢ␗ᡤᛶᒁᅾࡶほᐹࡉࢀࡓࠋATP7B R778LⅬኚ␗ࡀ࢘Ⓨ⾲Ꮫ఍࢕ࣝࢯࣥ⑓Ⓨ⑕ࢆᘬࡁ㉳ࡇࡍཎᅉ࡜᥎ ࡉࢀࡿࠋ࣭ ➨91ᅇ ᪥ᮏ⏕໬Ꮫ఍኱఍
(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ➨3ᅇ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍ᖺ఍࣭ ࢤࣀ࣒࣡࢖ࢻ࡞⤌᥮࠼ಟ᚟ಁ㐍ᅉᏊࡢࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡼࡗ࡚ࠊᘬ
࣭ Cold Spring Harbor Meeting 2018 Genome Engineering: Theࡁ⥆ࡁࡼࡾṇ☜࡞ࢤࣀ࣒⦅㞟ࢆࡶࡓࡽࡍᢏ⾡㛤Ⓨࢆ㐍ࡵࡿࠋ
CRISPR/Cas Revolution.
࣭ RBM20ࡢኚ␗ࡀᚰ➽⣽⬊࡟ࡶࡓࡽࡍᙳ㡪࡟ࡘ࠸࡚ࠊศᏊࣞ࣋ࣝࡢゎ࣭ ᫂἞⸆⛉኱Ꮫ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘
ᯒࢆࡉࡽ࡟㐍ࡵࡿࡇ࡜࡛ࠊᚰ➽⑕Ⓨ⑕ᶵᗎࡢ⌮ゎࢆ῝ࡵࠊ᪂ࡓ࡞἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡆࡿࠋ
(3) ᅜෆእࡢ◊✲≧ἣ࣭ ࢘࢕ࣝࢯࣥ⑓ཎᅉ㑇ఏᏊࡢATP7Bࡣ㖡ࢺࣛࣥࢫ࣏࣮ࢱ࣮࡛࠶ࡿࡓ
ᅜෆእ࡛ࠊiPS⣽⬊࡜ࢤࣀ࣒⦅㞟ࢆ⤌ࡳྜࢃࡏࡓ◊✲ࡣ┒
ࡵࠊATP7Bኚ␗ࢆಟṇࡋࡓiPS⣽⬊⏤᮶ࡢ⫢⮚⣽⬊ࡀᣢࡘ㖡㍺㏦ᶵ⬟ࢆホ౯ࡍࡿࠋⅬኚ␗ࡀATP7Bࢱࣥࣃࢡ㉁ࡢᏳᐃᛶࡸ⣽⬊ෆᒁᅾࢆኚ
ࢇ࡟㐍ࡵࡽࢀ࡚࠾ࡾࠊᇶ♏◊✲ࡸᢏ⾡㛤Ⓨ࡟ຍ࠼ࠊ⮫ᗋᛂ⏝໬ࡉࡏࡿᶵᵓࢆゎᯒࡍࡿࠋ࡟ྥࡅࡓྲྀ⤌ࡳࡶ㐍ࢇ࡛࠸ࡿࠋ(1)

ᴫせiPS⣽⬊࡟ࡣᵝࠎ࡞་⒪ᛂ⏝ࡀᮇᚅࡉࢀࠊ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࡀࠊࡑࡢࢤࣀ࣒ࢆ᧯సࡍࡿࡇ࡜ࡢᅔ㞴ࡉࡀ㧗࠸㞀ቨ࡜࡞ࡗ࡚ࡁࡓࠋࡋ࠿ࡋࠊࢤࣀ࣒⦅㞟ᢏ⾡ࡢⓎᒎ࡟ࡼࡾࠊࡑ
ࡢ㞀ቨࡶྲྀࡾᡶࢃࢀࡘࡘ࠶ࡿࠋ
ᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊiPS⣽⬊࡜ࢤࣀ࣒⦅㞟ᢏ⾡ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊ㑇ఏᛶ⑌ᝈࣔࢹࣝస〇࡟ࡼࡿ⑌ᝈࡢⓎ⑕ᶵᗎࡢゎᯒࠊ࠾ࡼࡧ⑌ᝈࡢཎᅉ࡜࡞ࡿኚ␗ࢆಟṇࡋࡓiPS⣽⬊࡟ࡼࡿ⣽⬊⛣᳜἞⒪ἲࡢ㛤Ⓨࢆ┠ᣦࡍࠋ୺࡞◊✲ᡂᯝ 

－ 31 －

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼ㄽᩥᥖ㍕
࣭ Nature. 565(7738):246-250 (2019)࣭ Nat Med. 23(6):723-732 (2017)⥲ㄝ࣭ J Biochem. pii: mvz017 (2019)࣭ Semin Immunopathol. 40(6):523-538 (2018)
࣭ Neurochem Int. pii: S0197-0186(18)30298-5 (2018)࣭ ⚄⤒໬Ꮫ 57(2):47-53 (2018)࣭ ᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍㞧ㄅ 30(1):77-81 (2018)࣭ ᪥ᮏ⸆⌮Ꮫ㞧ㄅ 151(1):9-14 (2018)࣭ ⏕໬Ꮫ 90(1):99-102 (2018)Ꮫ఍ㅮ₇㸦ᣍᚅㅮ₇㸧࣭ ➨44ᅇ᪥ᮏ⬻༞୰Ꮫ఍㞟఍࣭ ➨61ᅇ᪥ᮏ⚄⤒໬Ꮫ኱఍࣭ ➨91ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍
࣭ ➨61ᅇ᪥ᮏ⚄⤒໬Ꮫ኱఍࣭ Mt.Fuji Workshop on CVD࣭ ➨41ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭ ➨60ᅇ᪥ᮏ⬡㉁⏕໬Ꮫ఍࣭(3) ᅜෆእࡢ◊✲≧ἣ
ᖹᡂ30ᖺᗘࡣ⚄⤒ච␿࡟㛵㐃ࡍࡿㄽᩥࡀNatureࠊScience࡞࡝ࡢtop journal࡟┦ḟࡂࠊୡ⏺ⓗ㛵ᚰࡀ㧗ࡲࡗ࡚࠸ࡿࠋࡑࡢ
ࡼ࠺࡞୰࡛ࠊ⬻᱾ሰᚋࡢ⚄⤒ච␿Ꮫࢆ⚄⤒ಟ᚟Ꮫ࡬࡜Ⓨᒎࡉࡏࡿᙜࣉࣟࢪ࢙ࢡࢺ◊✲ࡣඛ㥑ⓗ࡛⊂๰ⓗ࡛࠶ࡿࠋ(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼௨ୖࡢ◊✲ᡂᯝࢆᅵྎ࡜ࡋ࡚ࠊձ⬻᱾ሰᚋࡢ⚄⤒ᅇ㊰ࡢಟ᚟ࢆㄏ
ᑟࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࠊղ⬻ෆ⅖⑕ࡢ཰᮰ࢆㄏᑟࡍࡿࢫ࢝࣋
ࣥࢪ࣮ࣕㄏᑟᅉᏊࡢྠᐃࠊճ⬻ ᱾ ሰ ᚋ ࡢ ⬻ ෆ ࡟ ࠾ ࡅ ࡿ ᶵ ⬟ ⓗ ⬡ ㉁ࡢ ྠ ᐃ ࡜ ἞ ⒪ ᛂ ⏝ ࠊ ࡢ 3ࡘࡢ◊✲ㄢ㢟ࢆ㐍ᒎࡉࡏࡿࠋࡑࡢࡓࡵࡢᇶ
┙࡜࡞ࡿ◊✲ᢏ⾡ࡣ☜❧࡛ࡁ࡚࠾ࡾࠊᖹᡂ31ᖺᗘࡣ◊✲ࢆ᏶ᡂࡉࡏࠊ
ㄽᩥసᡂࢆ┠ᣦࡍࠋ(2)⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞⅖⑕ច㉳ᅉᏊࡢྠᐃ
⬻⤌⧊ࣛ࢖ࢮ࣮ࢺ࠿ࡽ࣐ࢡࣟࣇ࢓࣮ࢪࢆάᛶ໬ࡍࡿ⏬ศࢆᢳ
ฟࡋࠊ⅖⑕ࢆច㉳ࡍࡿάᛶࢆᣢࡘෆᅉᛶࡢ⤌⧊ᅉᏊ࡜ࡋ࡚᪂ࡓ
࡟ DJ-1 ࢱࣥࣃࢡ㉁ࢆྠᐃࡋࡓࠋDJ-1 ࡣ⬻᱾ሰᕢ࡟࠾࠸࡚⹫⾑࡟㝗ࡗࡓ⚄⤒⣽⬊࡛⏘⏕ࡉࢀࡿᢠ㓟໬ࢱࣥࣃࢡ㉁࡛࠶ࡿࡀࠊ⚄⤒⣽⬊ࡢ⹫⾑ቯṚ࡟కࡗ࡚⣽⬊እ࡟ᨺฟࡉࢀࠊ⬻᱾ሰᕢ࡟ᾐ₶ࡋࡓዲ୰⌫ࡸ࣐ࢡࣟࣇ࢓࣮ࢪࢆ TLR2ࠊTLR4 ౫Ꮡⓗ࡟άᛶ໬ࡍ
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋDJ-1 ࡟ᑐࡍࡿ୰࿴ᢠయࡣࠊ⬻᱾ሰࣔࢹ࣐ࣝ࢘ࢫ࡟ᑐࡋ࡚⚄⤒ಖㆤຠᯝࢆ♧ࡍࡇ࡜࠿ࡽࠊ⣽⬊እࡢ
DJ-1 ࡣ⬻᱾ሰ࡟࠾ࡅࡿ᪂ࡓ࡞἞⒪ᶆⓗ࡜࡞ࡾᚓࡿࡇ࡜ࡀド࡛᫂
ࡁࡓࠋ

ղ

ᡂᯝࡢᴫせ
ձ ⬻᱾ሰᚋࡢ⅖⑕཰᮰࡜⚄⤒ಟ᚟࣓࢝ࢽࢬ࣒ࡢゎ᫂⬻᱾ሰᚋࡢ⅖⑕ࡢ཰᮰ࡸࢢ࣮ࣜ࢜ࢩࢫࡢᙧᡂ࡟ไᚚᛶT⣽⬊ࡢാࡁࡀ㔜せ࡛࠶ࡿࡇ࡜ࢆୡ⏺࡟ඛ㥑ࡅ࡚ሗ࿌ࡋࡓ㸦୐⏣ࡽࠊNature
2019㸧ࠋࡇࡢࡼ࠺࡟ࠊ⬻᱾ሰᕢ࡟ᾐ₶ࡋࡓච␿⣽⬊ࡣᙜึࡣ⅖⑕ࢆ㉳ࡇࡋ࡚࠸ࡿࡶࡢࡢࠊḟ➨࡟⚄⤒⤌⧊ࢆಟ᚟ࡍࡿస⏝࡟㌿ࡌࡿࠋ⬻᱾ሰᕢ࿘ᅖࡢ࣑ࢡࣟࢢࣜ࢔ࡸ⚄⤒⣽⬊ࡣḟ➨࡟⚄⤒ಟ᚟స⏝ࢆᣢࡘࡼ࠺࡟࡞ࡿࡀࠊࡇࢀࡽࡣ࢚ࣆࢪ࢙ࢿࢸ࢕ࢵࢡ࡞ไᚚࢆཷࡅ࡚࠸ࡿࡇ
࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࡘࡘ࠶ࡿࠋ⚄⤒ಟ᚟స⏝ࢆ௜୚ࡍࡿࢡ࣐ࣟࢳࣥ≧ែࢆᙧᡂࡍࡿศᏊ⩌ࢆྠᐃࡍࡿࡇ࡜࡟ᡂຌࡋ࡚࠸ࡿࠋ

(1)

ᴫせ⬻᱾ሰᚋࡢ⅖⑕ࢆಟ᚟࡟㌿᥮ࡍࡿ࣓࢝ࢽࢬ࣒ࢆࠊ⅖⑕཰᮰࡟⮳ࡽࡏࡿ⬻ෆᅉᏊࡢྠᐃࠊᦆയࡋࡓ⚄⤒ᅇ㊰ࢆಟ᚟ࡉࡏࡿᅉᏊࡢྠᐃࠊࡢ㸰ࡘࡢどⅬ࠿ࡽゎ᫂ࡍࡿࠋ

(1)

E

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 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ◊✲⪅ྡ
ᖖ໅◊✲ဨ
୐⏣ ᓫ
ᖹᯘဴஓ
㓇஭ㄔ୍㑻
ὠᒣ ῟

(1)

◊✲ᮇ㛫
2017ᖺ4᭶㹼2020ᖺ3᭶
㸦3 ᖺ㛫㸧

AE

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ⬻༞୰࡟࠾ࡅࡿ⅖⑕࡜ಟ᚟࣓࢝ࢽࢬ࣒ࡢゎ᫂㸭⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୐⏣ ᓫ㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 32 －

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Journal of Neurophysiology
࣭ PLoS One
࣭ Cerebellum࣭ Neuroscience Research࣭ Cerebellum Ataxias
࣭ Society for Neuroscience㸦⡿ᅜ㸧࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍࣭ ᪥ᮏ⚄⤒Ꮫ఍࣭ ᪥ᮏ⮫ᗋ⚄⤒⏕⌮Ꮫ఍࣭ ᪥ᮏᑠඣ⚄⤒Ꮫ఍
࣭ Motor Control◊✲఍࣭ ᅜ㝿ᑠ⬻Ꮫ఍(3)ᅜෆእࡢ◊✲≧ἣ㐠ື୰ᯡࡢ◊✲ࡣᮍࡔ࡟኱⬻༢⊂ࠊᑠ⬻༢⊂࠶ࡿ࠸ࡣᇶᗏ
᰾༢⊂ࢆᑐ㇟࡜ࡍࡿ◊✲ࡀᅽಽⓗ࡟ከࡃࠊࡇࢀࡽࡢ㐠ື୰ᯡࡀࢿࢵࢺ࣮࣡ࢡ࡜ࡋ࡚㐃㛵ࡍࡿᶵ⬟ཎ⌮ࢆゎ᫂ࡍࡿどⅬࡢ◊✲ࡣᏑᅾࡋ࡞࠸ࠋࡉࡽ࡟ࠊᇶ♏◊✲࡜⮫ᗋ◊✲ࡢ┦஌ຠᯝࢆ≺࠺◊✲ࡣᡃࠎࡢࢢ࣮ࣝࣉ௨እ࡟⾜ࢃࢀ࡚࠸࡞࠸ࠋࡑࡢព࿡
࡛ᡃࠎࡢ◊✲ࡣୡ⏺ⓗ࡟ぢ࡚ࡶ㠀ᖖ࡟ࣘࢽ࣮ࢡ࡞࣮࢜ࣥࣜ࣡
ࣥ࡟㏆࠸Ꮡᅾ࡛࠶ࡿࠋ

(2)(2) ௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼x ື≀ᐇ㦂㸸 ᫖ᖺᗘ࠿ࡽ㛤ጞࡋࡓ኱⬻ᇶᗏ᰾࠾ࡼࡧ኱⬻㐠ື㔝࠿ࡽࡢ⚄⤒άືグ㘓ࡣ㡰ㄪ࡟ఙᒎࡋ࡚࠾ࡾࠊࡇࢀࡲ࡛ࡢᑠ⬻⚄⤒ᅇ㊰࠿ࡽࡢグ㘓࡜ྜࢃࡏ࡚ࠊ኱⬻ࠊᑠ⬻ࠊᇶᗏ᰾࡜࠸࠺㐠ືࡢ୕኱୰ᯡࡀྠ
୍ࡢ㐠ື࡟ᑐࡋ࡚࡝ࡢࡼ࠺࡟ᙺ๭ศᢸࡋ࡚࠸ࡿ࠿࡜࠸࠺ᮍゎỴࡢ㞴ၥࢆゎࡃୡ⏺ึࡢࢹ࣮ࢱࢆᚓࡿ.
x ⮫ᗋᛂ⏝㸸㸦㸯㸧b)ࠋ⬻༞୰࡛ࡣࠊH30ᖺᗘ࡟⥆ࡁࠊ㔜⑕ᗘࡢ㧗࠸ᝈ⪅ࡢᅇ᚟㐣⛬ࡢ㛗ᮇ㏣㊧ࢆ⾜࠸ࠊࢹ࣮ࢱ࣮࣋ࢫ໬ࢆ㐍ࡵࡿࠋ㛗ᮇ㏣㊧౛ࡢ⑓ែࢹ࣮ࢱ࣮࣋ࢫࢆࠕࢼࣅࢤ࣮ࢱ࣮ࠖࡢ୰᰾࡜ࡋ࡚฼⏝ฟ᮶ࡿࡼ࠺࡟㛤Ⓨࢆ㐍ࡵࡿࠋx ⚄⤒⑓ែホ౯ࡢᐇ⏝໬㸸 Microsoft♫࡜ඹྠ࡛H30ᖺᗘ࡟Kinect v2ࢆ⏝࠸ࡓ㠀ᖖ࡟పࢥࢫࢺࡢ㐠ືᶵ⬟ホ౯ࢩࢫࢸ࣒ࢆ᏶ᡂࡉࡏࡓࠋ2019ᖺᗘࡣࠊࡇࡢࢩࢫࢸ࣒ࢆᑠ⬻⑌ᝈࠊᇶᗏ᰾⑌ᝈࠊ⬻༞୰ࡢ⑓ែホ౯࡟฼⏝ࡍࡿᐇ⏝໬◊✲ࢆ㐍ࡵࡿࠋࡇࡢ◊✲࡟ࡼࡾࠊ⚄⤒⑌ᝈࡢ⑓ែホ౯ࡢᐈほ໬ࡢᐇ⏝໬࡟┠㏵ࢆࡘࡅࡿࠋ

(1) ᡂᯝࡢᴫせa) ࡇࢀࡲ࡛࡟⵳✚ࡋࡓᑠ⬻ࡢ⚄⤒άືࢹ࣮ࢱ࡟ᇶ࡙ࡃᑠ⬻ືసཎ⌮ࡢゎ࡛᫂㢧ⴭ࡞ᡂᯝࡀ࠶ࡗࡓ㸸㐠ືㄢ㢟୰ࡢࢧࣝᑠ⬻ࡢධຊᒙ,୰㛫ᒙ,ฟຊᒙࡢ⚄⤒⣽⬊άືࡢグ㘓ࡀ᏶ᡂࡋ㸦Tomatsu et al. J Neurophysiol,
2016㸧ࠊࡑࢀཷࡅ࡚H29-30ᖺᗘࡣᑠ⬻࡟࠾ࡅࡿ᝟ሗኚ᥮ࣔࢹࣝࡢศ
ᯒࢆ⾜ࡗࡓࠋᑠ⬻ࡢྛࢫࢸࢵࣉ࡟࠾ࡅࡿ᝟ሗኚ᥮࡟ࡘ࠸࡚ࠊ඲࡚ࡢ
⚄⤒⣽⬊ࢹ࣮ࢱࢆ฼⏝ࡋ࡚ᵝࠎ࡞ᩘᏛⓗࣔࢹࣝࢆ᳨ドࡋࡓࠋண᝿࡟
཯ࡋ࡚ձᑠ⬻ྛᒙ㛫ࡢኚ᥮࢔ࣝࢦࣜࢬ࣒ࡣ༢⣧࡞⥺ᙧኚ᥮࡛ㄝ᫂ࡉ
ࢀࡿ㸹ղᑠ⬻ࡢ᝟ሗኚ᥮඲యࡣࠋ࣐࢝ࣝࣥࣇ࢕ࣝࢱ࣮࡜࿧ࡤࢀࡿᕤᏛ ⓗ ไ ᚚ ࢔ ࣝ ࢦ ࣜ ࢬ ࣒ ࡜ ➼ ౯ ࡛ ࠶ ࡗ ࡓ (Tanaka et al. Cerebellum,2019)ࠋࡇࢀࡣᑠ⬻ࡢࡼ࠺࡞኱つᶍ࡞⚄⤒ᵓ㐀࡛ືసཎ⌮ࡢ࢔ࣝࢦࣜ
ࢬ࣒ࡀゎ᫂ࡉࢀࡓୡ⏺ึࡢᡂᯝ࡛࠶ࡿࠋb) ⚄⤒⑌ᝈ἞⒪ࢼࣅࢤ࣮ࢱ࣮㛵㐃㸦⮫ᗋ◊✲㸧㸸ձ⬻༞୰ᝈ⪅ࡢ㛗ᮇ
⑓ែ㏣㊧ࢆࡉࡽ࡟᥎㐍ࡋࠊղ⬨㧊ᑠ⬻ኚᛶ⑕ࡢ᪩ᮇ㸦⣽⬊⬺ⴠ๓㸧Ⓨぢ᪉ἲࡢ╔᝿ࢆᚓࡓࠋձࡣ⚄⤒⑌ᝈࡢ⑓ែ3ᣦᶆ㸦ண ไᚚㄗᕪ,ࣇ࢕࣮ࢻࣂࢵࢡไᚚㄗᕪ,㧗࿘Ἴࣀ࢖ࢬ㸧ࢆ౑࠸ࠊ60౛ࡢᝈ⪅࡛㛗ᮇ
㏣㊧ࢹ࣮ࢱࢆᚓࡓࠋղ࡟ࡘ࠸࡚ࡣ๓㢌๓㔝࠿ࡽᑠ⬻ᚋ㠃࡬ࡢᙉຊ࡞
ᢞᑕ࡟ࡼࡿㄏⓎ㟁఩ࡢኚᐜࢆከࢳࣕࣥࢿࣝ⬻Ἴィ ᳨࡛ฟࡍࡿ࢔࢖
ࢹ࢕࢔ࡢ᳨ドࢆື≀ᐇ㦂࡜ࣄࢺࡢᐇ㦂᳨࡛ド୰࡛࠶ࡿࠋᴫせ⬻༞୰࣭ࣃ࣮࢟ࣥࢯࣥ⑓࣭⬨㧊ᑠ⬻ኚᛶ⑕ࡢ἞⒪ࡣࠊ⬻ࡢ㧗ḟ㐠ື୰ᯡࡢᶵ⬟ཎ⌮ࡀᮍゎ᫂࡞ࡓࡵࠊ⑓ែゎ᫂ࡀ㐍ࡲࡎᑐ⑕⒪ἲ࡟␃ࡲࡿࠋࡑࡇ࡛ື≀ᐇ㦂࡜ࣄࢺࢆᑐ㇟࡜ࡍ
ࡿ◊✲ࢆࠊ୧⪅ࡢ฼Ⅼࢆ⤌ࡳྜࢃࡏ࡚┦⿵ⓗ࡟⾜࠸ࠊ㐠ື㔝㸪ᇶᗏ᰾㸪ᑠ⬻ࡢ㸱ࡘࡢ㐠ື୰ᯡࡢᶵ⬟ཎ⌮ࢆゎ᫂ࡍࡿࠋࡑࡢᡂᯝ࡟ᇶ࡙ࡁ⑓ែࡢᐈほⓗホ౯ࢆྍ⬟࡟ࡍࡿ⚄⤒⑌ᝈ἞⒪ࢼࣅࢤ࣮ࢱ࣮ࢆ☜❧ࡍࡿࠋ

(1)

E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
Ỉ⃝ⱥὒ㸦ᅜ❧⢭⚄⚄⤒་⒪◊✲ࢭࣥࢱ࣮⥲㛗㸧ṇ㛛⏤ஂ㸦ᮾᾏ኱ᩍᤵ㸧୕Ɫ ༤㸦ᮾி་኱ᩍᤵ㸧ᒸ⏣Ᏻᘯ㸦⚄ᡞ኱ྡ㄃ᩍᤵ㸧ᒣᓮ ໷㸦㟁㏻኱෸ᩍᤵ㸧⏣୰ᏹ࿴㸦JAIST෸ᩍᤵ㸧☾㷂ⱥ἞㸦⚄⤒⑓㝔㛗㸧ᶓᆅᡣᏊ㸦⚄⤒⑓㝔㸧㣕⃝᫴௓㸦⚄⤒⑓㝔㸧⇃⏣⪽Ꮚ㸦⚄⤒⑓㝔㸧ụ⃝ ῟㸦⚄⤒⑓㝔㸧(2) ◊✲⪅ྡ
⟍ ៅ἞
ఀ⸨ᏹྖ
ᮤ 㙂ᪿ
▼ᕝாᏹ
㛬 ᗒ⏠
ᮏከṊᑛ
ྜྷ⏣኱ᓠ
Ώ㒊㞞ஓ

(1)

◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ㐠ື㞀ᐖࡢ⑓ែゎ᫂࡜⚄⤒⑌ᝈ἞⒪ࢼࣅࢤ࣮ࢱ࣮ࡢ㛤Ⓨ㸭㐠ື㞀ᐖࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸⟍ ៅ἞㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 33 －

(1)ᅜෆእ䛾◊✲≧ἣṇᖖ║ᅽ⥳ෆ㞀ࣔࢹࣝື≀ࡢ☜❧ࡣୡ⏺ึࡢᡂᯝ࡛࠶ࡿࠋ㟋㛗㢮ࢆ⏝࠸ࡓ⚄⤒ಖㆤࠊど⚄⤒෌⏕࡞࡝ࡢ║⛉◊✲ࡣࠊୡ⏺ⓗ࡟ࡶࡲࡔ࡯࡜ࢇ࡝⾜ࢃࢀ࡚࠸࡞࠸ࠋ

(3)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼࣭ ➨㸱ᮇࣉࣟࢪ࢙ࢡࢺ࡟࠾࠸࡚ࡣࠊࡼࡾࣄࢺ࡟㏆࠸ᙧែⓗ≉ᚩ࡜どᶵ⬟ࢆྜࢃࡏᣢ
ࡘ㟋㛗㢮ࢆά⏝ࡋ࡚ࠊ㞴἞ᛶ║⑌ᝈ࡟ᑐࡍࡿ⚄⤒ಖㆤ࠾ࡼࡧど⚄⤒෌⏕◊✲ࢆࡉࡽ࡟ຍ㏿ࡉࡏࡿィ⏬࡛࠶ࡿࠋࡇࡢ┠ⓗࢆ㐩ᡂࡍࡿࡓࡵࠊୖ㏙ࡢ⮬↛Ⓨ⑕⥳ෆ㞀ಶయࡢヲ⣽࡞ゎᯒ࡟ຍ࠼࡚ࠊୡ⏺ึࡢ㑇ఏᏊᨵኚ⥳ෆ㞀࣐࣮ࣔࢭࢵࢺࡢసᡂࡀ㐍⾜
୰࡛࠶ࡿࠋ

(2)

(2)

࣭ ⥳ෆ㞀ࡢཎᅉ࡜ࡋ࡚㧗║ᅽ௨እ࡟㑇ఏᏊ␗ᖖࡀ▱ࡽࢀ࡚࠸ࡿࡀࠊ඲య࡛ࡣ 10㸣௨ୗ࡛࠶ࡿࠋ≉࡟ᅜෆࡢ⥳ෆ㞀ࡢ⣙㸵๭ࢆ༨ࡵࡿṇᖖ║ᅽ⥳ෆ㞀㸦NTG㸧࡟࠾࠸࡚ࡣࠊᵝࠎ࡞඲㌟ⓗせᅉࡢ㛵୚ࡀ᝿ᐃࡉࢀࡿࠋᙜࣉࣟࢪ࢙ࢡࢺ࡛ࡣ NTG ࣔࢹࣝື≀㸦ࢢࣝࢱ࣑ࣥ㓟㍺㏦య࡛࠶ࡿ EAAC1 ࡲࡓࡣ GLAST Ḟᦆ࣐࢘ࢫ㸧ࡢゎᯒ࡞࡝࠿ࡽࠕຍ㱋࡟ࡼࡿࢢࣝࢱ࣑ࣥ㓟㍺㏦యࡢⓎ⌧㔞పୗЍࢢࣝࢱࢳ࢜ࣥࡢ⏘⏕పୗЍ㓟໬ࢫࢺࣞࢫࡢஹ㐍ࠖ➼ࡀ⑓ែ࡟㛵୚ࡍࡿྍ⬟ᛶࢆ⪃៖ࡋ࡚࠸ࡿࠋ୍᪉ࠊ⠠≧ᯈࡢᏑᅾࡋ࡞࠸࣐࢘ࢫ࡛ࡣࠊ≉ᚩⓗ࡞ど㔝㞀ᐖࣃࢱ࣮ࣥࡢ෌⌧ࡣ୙ྍ⬟࡛࠶ࡿࡇ࡜࠿
ࡽࠊᡃࠎࡣࡼࡾࣄࢺ࡟㏆࠸ࣔࢹࣝ࡜ࡋ࡚ࠊ⪁㱋࣐࣮ࣔࢭࢵࢺࡢ᳨ウࢆ㛤ጞࡋ࡚࠸ࡿࠋᡃࠎࡀⓎぢࡋࡓ⮬↛Ⓨ⑕ NTG ࣐࣮ࣔࢭࢵࢺ࡛ࡣࠕど⚄⤒࣭どぬ㔝࡟࠾ࡅࡿ⚄⤒ᰤ㣴ᅉᏊࡢⓎ⌧పୗࠖࠊࠕ⬻⬨㧊ᅽࡢపୗ㸦┦ᑐⓗ࡞║ᅽୖ᪼㸧ࠖࡸࠕ║⾑ὶ㔞ࡢపୗࠖ࡞࡝ࠊ⥳ෆ㞀ᝈ⪅࡟㢮ఝࡋࡓᡤぢࡀ」ᩘ☜ㄆࡉࢀ࡚࠾ࡾࠊ᭷⏝࡞ࣔࢹࣝ࡜࡞ࡿྍ⬟ᛶࡀᮇᚅࡉࢀࡿ㸦ᢞ✏୰㸧ࠋ௨ୖࡢࡼ࠺࡞⑌ᝈࣔࢹࣝ࡟㛵ࡍࡿ⥲ㄝࢆᅜ㝿ⓗ࡞ᑓ㛛ㄅ࡟Ⓨ⾲ࡋࡓ㸦British Journal of Ophthalmology, 2019㸧ࠋ࣭ ⥳ෆ㞀἞⒪࡟࠾࠸࡚ࡣ║ᅽୗ㝆⒪ἲ࡟ຍ࠼࡚ࠊ⚄⤒ಖㆤస⏝ࢆ᭷ࡍࡿ἞⒪ἲࡢ☜❧ࡀᮃࡲࢀ࡚࠸ࡿࠋࡑࡇ࡛ cysteine ๓㥑య࡛࠶ࡿ N-acetylcysteine㸦NAC㸧ࢆ NTG
ࣔࢹࣝື≀࡟ᢞ୚ࡋࠊ⥳ෆ㞀ࡢᢚไຠᯝࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊEAAC1 Ḟᦆ࣐࢘ࢫ࡛ࡣᢠ㓟໬స⏝ࢆ᭷ࡍࡿࢢࣝࢱࢳ࢜ࣥࡢⓎ⌧ୖ᪼࡟ຍ࠼࡚ࠊ㓟໬ࢫࢺࣞࢫ࠾ࡼ
ࡧ autophagy ࡢ࣐࣮࣮࢝Ⓨ⌧㔞ࡀῶᑡࡋࠊ⥳ෆ㞀ࡢ㐍⾜ࡀᢚไࡉࢀࡓࠋ୍᪉ࠊ
GLAST Ḟᦆ࣐࢘ࢫ࡛ࡣ NAC ᢞ୚࡟ࡼࡿࢢࣝࢱࢳ࢜ࣥࡢ⏘⏕ቑຍࡣぢࡽࢀࡎࠊ⚄⤒ಖㆤຠᯝࡶほᐹࡉࢀ࡞࠿ࡗࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽ EAAC1 Ḟᦆ࣐࢘ࢫࡢ⥙⭷ኚᛶ࡟ࡣ cysteine ࡢ⿵඘ࡀ᭷ຠ࡛࠶ࡿࡀࠊGLAST Ḟᦆ࣐࢘ࢫ࡛ࡣࢢࣝࢱ࣑ࣥ㓟ẘᛶࡢᙳ㡪ࡀࡼࡾᙉ࠸࡞࡝ࠊ୧⪅ࡢ⑓ែࡀ␗࡞ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋཤ⑱⸆࡞࡝࡜ࡋ
࡚Ᏻ඲ᛶࡀ☜ㄆࡉࢀࡓ᪤Ꮡ⸆࡛࠶ࡿ NAC ࡣࠊ๓⪅࡟ヱᙜࡍࡿ⫼ᬒࢆᣢࡘ⥳ෆ㞀ࡢ἞⒪࡟࠾࠸࡚᭷⏝࡞ྍ⬟ᛶࡀ࠶ࡿ㸦Cell Death and Disease, 2019㸧ࠋ࣭ Ripasudil ࡣ Rho/ROCK 㜼ᐖ๣࡜ࡋ࡚ึࡢ⥳ෆ㞀Ⅼ║⸆࡜ࡋ࡚౑⏝ࡉࢀ࡚࠸ࡿࡀࠊ
║ᅽ㝆ୗ௨እࡢస⏝ᶵᗎࡣᚲࡎࡋࡶ᫂☜࡛ࡣ࡞࠸ࠋEAAC1 Ḟᦆ࣐࢘ࢫ࡛ࡣ⥙⭷ኚᛶࡀጞࡲࡿ๓ࡢ⏕ᚋ 5 㐌࠿ࡽ⚄⤒⣽⬊Ṛࢆㄏᑟࡍࡿ p38 MAPK ࡀ⥙⭷⚄⤒⠇⣽⬊
ᒙ࡛άᛶ໬ࡉࢀࡿࡀࠊRipasudil Ⅼ║⩌࡛ࡣࡑࡢάᛶ໬ࡀ᭷ព࡟ᢚไࡉࢀ࡚࠸ࡓࠋ
௨ୖ࠿ࡽ Ripasudil Ⅼ║ࡢస⏝ᶵᗎ࡜ࡋ࡚ࡣ║ᅽ㝆ୗ࡟ຍ࠼࡚ࠊ⚄⤒ಖㆤຠᯝࡶྵ
ࡲࢀࡿࡇ࡜ࡀண᝿ࡉࢀࡿ㸦Investigative Ophthalmology & Visual Science, 2018㸧ࠋ

ᡂᯝࡢᴫせ

E

ㄽᩥᥖ㍕ㄅ䞉Ⓨ⾲Ꮫ఍ྡ➼࣭ Sano et al. Cell Death and Disease, 2019࣭ Harada et al. British Journal of Ophthalmology, 2019
࣭ Akaiwa et al. Investigative Ophthalmology & Visual Science, 2018
࣭ Azuchi et al. Scientific Reports, 2018
࣭ Takayuki Harada. Spontaneous normal tension glaucoma in aged
marmosets. 8th World Glaucoma Congress (WGC 2019), 2019.3.30,
Melbourne, Australia
࣭ Kazuhiko Namekata. DOCK8 regulates microglial activity inneuroinflammation. 19th International Congress of Neuropathology,
2018.9.26, Tokyo, Japan࣭ Xiaoli Guo. New therapeutic targets on neurodegenerative anddemyelination diseases. Overseas Chinese, Chinese and High-Level
Talents Travel to Jiangsu. 2018.8.23, Jiangsu, China (INVITED)࣭ Atsuko Kimura. Can valproic acid treat neurodegenerative diseases?
International Conference on Neurovascular and Neurodegenerative
Diseases, 2018.10.15, Narita, Japan (INVITED)࣭ Yuriko Azuchi, et al. Loss of neuritin accelerates RGC loss and retinaldegeneration in adult mice following optic nerve injury. Annual
Meeting of the Society for Neuroscience, 2018.11.5, San Diego, USA(1)㻌◊㻌 㻌 㻌 㻌 㻌 㻌 㻌✲㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᡂ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌ᯝ
㻌㻌

E

㻌◊
㻌 㻌 ✲ᮇ㛫䞉◊✲⪅ྡ➼㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌(2) ◊✲⪅ྡ
ཎ⏣㧗ᖾ
⾜᪉࿴ᙪ
㒌 ᬡ㯇
ᮌᮧᩔᏊ
㔝࿅㝯ᙪ
㔠 ⩏㐨㸦ᮾிឿᜨ఍་⛉኱Ꮫ║⛉㸧బᇣᘯᶞ㸦ᚨᓥ኱Ꮫ║⛉㸧ᮏ⏣⣪㔛㸦㡰ኳᇽ኱Ꮫ║⛉㸧໭ᮧ⿱ኴ㸦༓ⴥ኱Ꮫ║⛉㸧
ཎ⏣▱ຍᏊ
⛅ᒣᝅ୍
ᏳᅵࡺࡾᏊ
㸦ᮾ㑥኱Ꮫ⌮Ꮫ㒊㸧

(1)

◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5 ᖺ㛫㸧

A

㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸ཎ⏣㧗ᖾ㸧㸦◊✲௦⾲⪅ྡ㸧◊㻌 㻌 ✲㻌 㻌 ෆ㻌 㻌 ᐜ⥙⭷࣭ど⚄⤒ኚᛶ⑌ᝈࡢ⑓ែゎ᫂࡜἞⒪ἲ㸭どぬ⑓ែࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ

◊✲ㄢ㢟ྡ

ᴫせ
᪥ᮏ࡟࠾ࡅࡿ୰㏵ኻ᫂ཎᅉࡢከࡃࡣ⥙⭷࠾ࡼࡧど⚄⤒ࡢኚᛶ⑌ᝈ
࡛࠶ࡿࠋ≉࡟Ḣ⡿ᆺࣛ࢖ࣇࢫࢱ࢖ࣝࡢᾐ㏱ࡸ㧗㱋໬♫఍ࢆ⫼ᬒ࡟ࠕ║ࡢᡂே⑓ࠖ࡜ࡶ࠸࠼ࡿ⥳ෆ㞀ࡸ⢾ᒀ⑓⥙⭷⑕࡞࡝ࡢᝈ⪅ᩘቑຍࡀ኱ࡁ࡞ㄢ㢟࡜࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣ㧗㱋໬ࢆ㏄࠼ࡿ᪥ᮏ♫఍඲యࡢ 42/ ྥୖ࡜ࠊ㒔Ẹࡢࢽ࣮ࢬ࡟ᗈࡃᛂ࠼ࡿࡓࡵ࡟ࠊ㞴἞ᛶ║⑌ᝈࣔࢹࣝࡢ㛤Ⓨࢆ㏻ࡋ࡚ࠊࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒࡜἞⒪ἲ㛤Ⓨࢆ┠ᣦࡍࠋ

୺࡞◊✲ᡂᯝ 

－ 34 －

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ Neurology, Muscle& Nerve, Nursing and Health Science.
࣭ ᪥ᮏ⚄⤒Ꮫ఍࣭ ᪥ᮏ⚄⤒἞⒪Ꮫ఍
࣭ ᪥ᮏ࿧྾ࢣ࢔ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍࣭ ᪥ᮏ┳ㆤ⛉ᏛᏛ఍࣭ ᪥ᮏ㞴⑓┳ㆤᏛ఍(3)ᅜෆእࡢ◊✲≧ἣཎᅉ✲᫂࡟㛵ࡍࡿ◊✲ሗ࿌ࡸ⮫ᗋ἞㦂ࡢ」ᩘྠ᫬ᐇ᪋࡞
࡝ࠊ἞⒪ἲ㛤Ⓨ࡟ྥࡅࡓྲྀࡾ⤌ࡳࡀ๓㐍ࡋ࡚࠾ࡾࠊ㐍⾜ᢚไࡸணᚋࡢ㐍ᒎࡀᮇᚅ࡛ࡁࡿ㌿᥮ᮇࢆ㏄࠼ࡼ࠺࡜ࡋ࡚࠸ࡿࠋ
㞴⑓་⒪ἲࡢ᪋⾜㸦2015㸧ࡸ㞀ᐖ⪅ᕪูゎᾘἲ㸦2016㸧࡞࡝ࠊ♫఍᝟ໃࡢ኱ࡁ࡞㌿᥮ᮇࡢ୰ࠊ᫬௦࡟༶ࡋࡓಖ೺࣭་⒪࣭⚟♴ࡢ㐃ᦠ࡟ࡼࡿࢧ࣮ࣅࢫᥦ౪యไࡢ☜❧ࡀᚲせ࡛࠶ࡿࡀࠊ㞴⑓࡟࠾࠸࡚ࡇࢀࡽࢆ⤫ྜࡋࡓ◊✲άືࢆ⾜ࡗ࡚࠸ࡿ᪋タࡣࠊᙜᡤࢆ࠾࠸࡚ࡢ௚࡟ࡣぢᙜࡓࡽ࡞࠸ࠋேᕤ࿧྾⒪ἲࡢᬑཬ࣭㛗ᮇ໬࡟కࡗ࡚⏕ࡌࡓ᪂ࡓ࡞ၥ㢟ࡸᇶ♏⮫ᗋ◊✲ᡂᯝ࡟ࡼࡗ࡚᫂ࡽ࠿࡜࡞ࡗ࡚ࡁ࡚࠸ࡿㄢ㢟ࢆඞ᭹ࡍࡿࡓࡵࡢ┳ㆤࢣ࢔ᢏ⾡ࡢ㛤ⓎࡀồࡵࡽࢀࠊALSࢆࣔࢹࣝ࡟㞴⑓඲⯡࡟ᛂ⏝ࡋ࡚࠸ࡃࡇ࡜ࡀồࡵࡽࢀ࡚࠸ࡿࠋ

(2)

(2)

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼ୖグࡢ◊✲ࢆࠊ㒔❧⚄⤒⑓㝔࡜ࡢ㐃ᦠࡢࡶ࡜ࠊ᭦࡟᥎㐍ࡋࠊᇶ♏࣭⮫ᗋ་Ꮫࢆᇶ┙࡜ࡋࡓALSᝈ⪅ࡢ┳ㆤࢣ࢔ᢏ⾡ࡢ㛤Ⓨ࡜㞴⑓඲⯡࡬ࡢᛂ⏝ࠊ♫఍᝟ໃࡢኚ໬࡟ᑐᛂࡋࡓᏳ඲࡞⒪㣴⎔ቃ࣭ᨭ᥼ࢩࢫࢸ࣒ࡢᵓ⠏࡟ࡘ࠸࡚♫఍㑏ඖ࡟ࡘ࡞ࡀࡿࡼ࠺ດຊࡍࡿࠋᡂᯝࡢᴫせ࣭ Ẽ⟶ษ㛤ேᕤ࿧྾ᐇ᪋୰ࡢALSᝈ⪅ࡢྜే⑕࣭㝶క⑕≧㸦Nonmotor manifestations㸧ࡢ⤒ᖺㄪᰝࢆ⥅⥆ࡋࡓࠋ㛗ᮇேᕤ࿧྾⒪ἲ᪋⾜࡟ࡼࡿ⫵ྜే⑕ࡣࠊ⬚⭷ࡢ㧗ᗘ⒵╔࡟ࡼࡾ⏕ࡌࡿࡇ࡜ࢆ
๗᳨౛ࡢ⑓⌮Ꮫᡤぢ࡜ࡢ↷ྜ࡟ࡼࡾ☜ㄆࡋࠊ┳ㆤࠊ⮫ᗋᡤぢ࡜⑓⌮ᡤぢࢆ୍య໬ࡍࡿ┳ㆤ࣭⮫ᗋ࣭⑓⌮ࢹ࣮ࢱ࣮࣋ࢫᵓ⠏ࢆ╔᝿ࡋࡓࠋ࣭ Ẽ㐨ศἪ≀ၻฟ⬟ຊࡢᣦᶆࡢ୍ࡘ࡜ࡋ࡚⏝࠸ࡽࢀࡿ࢝ࣇࣆ࣮ࢡ
ࣇ࣮ࣟ㸦CPF㸧ࡢపୗ⋡࡜⮫ᗋⓗ≉ᚩ࡜ࡢ㛵㐃࡟ࡘ࠸᳨࡚ウࡋ
ࡓࠋCPFపୗ⋡ࡣࠊALSFRS-R ⌫ࢫࢥ࢔࠾ࡼࡧFVCࡢపୗ⋡࡜᭷ព࡟┦㛵ࡋࠊపୗ⋡ࡀ25㸣௨ୖࡢᝈ⪅ࡣ඲⏕Ꮡᮇ㛫ࡀࡼࡾ▷࠿ࡗࡓ㸦p <0.0001㸧ࠋCPFపୗ⋡ࡣ⌫㯞⑷࡜࿧྾୙඲ࡢ㐍⾜ࢆ཯ᫎࡋ⏕࿨ணᚋࡢண ᅉᏊ࡛࠶ࡿࡇ࡜ᣦ᦬ࡋࡓࠋ࣭ ᅾᏯ࡛ࡢ┳ㆤ⫋࣭௓ㆤ⫋ࡢ㐃ᦠᣦᶆ࡟ᇶ࡙ࡃ඲ᅜㄪᰝ࡟ࡼࡾࠊ
6ࢣ࢔ሙ㠃ࢆᢳฟࡋࠊ㐃ᦠ࡟ࡼࡿࣜࢫࢡ⟶⌮ࣉࣟࢢ࣒ࣛࢆ᏶ᡂ
ࡋࡓࠋᅾᏯேᕤ࿧྾⟶⌮࢖ࣥࢩࢹࣥࢺ᝟ሗwebࢩࢫࢸ࣒࡟ࡼࡾ
ᅾᏯ་⒪Ᏻ඲ࡢᬑཬၨⓎ஦౛࡜ࡋ࡚7౛ࢆ᭦᪂ࡋࡓࠋ࣭ ࠕ㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ࠖ࡟࠾ࡅࡿ༠㆟ෆᐜࡢศᯒࢆ㐍ࡵࠊ≉࡟⅏ᐖ᫬ᑐ⟇࡟ࡘ࠸࡚ࠊỈᐖ࠶ࡿ࠸ࡣ㛗᫬㛫೵㟁࡬ࡢഛ࠼ࡢᚲせᛶࢆᣦ᦬ࡋࡓࠋ࣭ 㞴⑓ἲ᪋⾜ᚋࡢ㞴⑓ᝈ⪅ࡢ⏕άᐇែㄪᰝ࠿ࡽࠊ㞴⑓ᝈ⪅ࡢ⒪㣴
ീ࡜ࡋ࡚ࠊ᭱㔜ᗘࡢ⚄⤒⣔ࠊADL㞀ᐖᑡ࡞࠸ࡀ⑕≧ࡢኚື኱ࡁ
࠸⑌ᝈ⩌ࠊADL⮬❧࡛ᑵປ⋡ࡶ㧗࠸⑌ᝈ⩌(┠࡟ぢ࠼࡞࠸㞀ᐖ)
ࡢ3㢮ᆺ໬ࢆᅗࡗࡓࠋ
(1)

ᴫせ࣭ ពᛮఏ㐩ᨭ᥼ᢏ⾡࣭ᨭ᥼యไࡢᵓ⠏࣭ Ẽ㐨ί໬ཱྀ࣭⭍ࢣ࢔ᢏ⾡ࡢ☜❧࣭ ┳ㆤࢣ࢔ᢏ⾡㛤Ⓨࡢᇶ┙࡜࡞ࡿᇶ♏࣭⮫ᗋ◊✲࣭ ┳ㆤ࣭௓ㆤ㐃ᦠ㉁ᣦᶆࡢ㛤Ⓨ࡜ᅾᏯ་⒪Ᏻ඲ࢩࢫࢸ࣒ᵓ
⠏࣭ ALS➼⒪㣴⪅ࡢࢣ࢔ࢩࢫࢸ࣒(ホ౯)ᣦᶆࡢ㛤Ⓨ࡜ホ౯࣭ 㞴⑓ࢣ࢔┳ㆤࢹ࣮ࢱ࣮࣋ࢫ࡟ࡼࡿ◊✲ᡂᯝࡢᬑཬࠋ

(1)◊       ✲       ᡂ       ᯝ

E

E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ◊✲⪅ྡ୰ᒣඃᏘ㸦་Ꮫ◊㸧ᑠ಴ᮁᏊ ་Ꮫ◊ ཎཱྀ㐨Ꮚ ་Ꮫ◊ ᯇ⏣༓᫓㸦་Ꮫ◊㸧ᯈᇉࡺࡳ㸦་Ꮫ◊㸧ΎỈಇኵ ⚄⤒⑓㝔 ᑠ᳃㝯ྖ ⚄⤒⑓㝔 ᕝ⏣᫂ᗈ ⚄⤒⑓㝔 ᮌ⏣⪔ኴ ⚄⤒⑓㝔 ᕝᮧబ࿴Ꮚ ⪷㞔ࢡࣜࢫࢺࣇ࢓࣮኱Ꮫ㸧(1)◊✲ᮇ㛫2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୰ᒣඃᏘ㸧㸦◊✲௦⾲⪅ྡ㸧
A

ALS➼⚄⤒㞴⑓⒪㣴⪅࡬ࡢ┳ㆤࢣ࢔࠾ࡼࡧ⒪㣴ᨭ᥼ࢩࢫࢸ࣒ࡢ㛤Ⓨ࣭ホ౯㸭㞴⑓ࢣ࢔┳ㆤࣉࣟࢪ࢙ࢡࢺ

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ 

－ 35 －

௒ᚋࡢぢ㎸ࡳ࣭ィ⏬➼⢾ᒀ⑓ᛶᮎᲈ⚄⤒㞀ᐖࡢ⣽⬊࣭ಶయ࡛ࣞ࣋ࣝࡢゎᯒࢆ㐍ࡵࠊᡂᅉ࡟ᇶ࡙ࡃ἞⒪⸆ࡢ㛤Ⓨ࡟㈉⊩ࡍࡿࠋ㔝⏕ᆺ࠾ࡼࡧኚᛶᛶㄆ
▱⑕ࣔࢹࣝࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ㧗⢾㉁㣗ࡲࡓࡣ㧗⬡⫫㣗࡛㣫⫱ࡋࠊ⚄⤒ኚᛶࠊ⢾໬≀⵳✚ࠊ㓟໬ࢫࢺࣞࢫஹ㐍࡬ࡢᙳ㡪ࢆ᳨ウࡍࡿࠋࡲࡓ௚᪋タ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ㑇ఏᛶࠊ⸆๣ᛶࠊච␿
௓ᅾᛶᮎᲈ⚄⤒㞀ᐖࡢ⑓ែゎ᫂࡟㈉⊩ࡍࡿࠋᅜෆእࡢ◊✲≧ἣ⢾ᒀ⑓࡟క࠺ᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢᇶ♏◊✲࡟ᚑ஦ࡍࡿ
◊✲⪅࣭་ᖌࡀᑡ࡞࠸≧ἣࡢ୰࡛ࠊᙜࣉࣟࢪ࢙ࢡࢺࡣ୺せ◊✲ᣐⅬࡢ୍ࡘ࡜ࡋ࡚ᮇᚅࡉࢀ࡚࠸ࡿࠋᘯ๓኱ࠊឿᜨ་኱ࠊឡ
▱Ꮫ㝔኱㸦ᮎᲈ⚄⤒㞀ᐖ㸧ࠊ㜰኱ࠊⰪᾆᕤ኱㸦ㄆ▱⑕㸧➼࡜ࡢඹྠ◊✲ࢆ᥎㐍ࡋࠊࡑࡢᡂᯝࢆ㒔ᨻ࡟㑏ඖࡍࡿ࡜࡜ࡶ࡟ᅜ
ෆእ࡟ྥࡅ࡚ᗈࡃⓎಙࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋ

ㄽᩥᥖ㍕ㄅ࣭Ⓨ⾲Ꮫ఍ྡ➼࣭ J Neurochem (2015, 2018)
࣭ Histochem Cell Biol (2015, 2018)
࣭ Neurosci Res (2015, 2019)
࣭ Eur J Neurosci (2016)࣭ Nat Commun (2019)࣭ ᪥ᮏ⢾ᒀ⑓Ꮫ఍࣭ ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍࣭ ᪥ᮏ⚄⤒⛉ᏛᏛ఍࣭ ᪥ᮏᮎᲈ⚄⤒Ꮫ఍࣭ ᪥ᮏ⏕⌮Ꮫ఍࣭ ᪥ᮏ⑓ែ⏕⌮Ꮫ఍࣭ ᪥ᮏศᏊ⏕≀Ꮫ఍࣭ ᪥ᮏ⏕໬Ꮫ఍࣭ ᪥ᮏㄆ▱⑕Ꮫ఍࣭ Ḣᕞ⢾ᒀ⑓Ꮫ఍࣭⚄⤒㞀ᐖศ⛉఍ (Neurodiab)



(3)

(2)

(2)

ᡂᯝࡢᴫせ
࣭ ࢔ࣝࢻ࣮ࢫ㑏ඖ㓝⣲㑇ఏᏊḞᦆ࣐࢘ࢫࡼࡾᶞ❧ࡋࡓࢩࣗ࣡ࣥ⣽⬊ᰴIKARS1ࡣࠊ࣏࣮ࣜ࢜ࣝ௦ㅰ⣔㓝⣲ࡢmRNA࣭⺮ⓑⓎ⌧పୗ࡜࢔ࣝࢹࣄࢻ௦ㅰ㓝⣲⩌ࡢ mRNAⓎ⌧ୖ᪼ࢆ࿊ࡋࡓ (JNeurochem 2018; Neural Reg Res 2018)ࠋ
࣭ 㧗ࢢࣝࢥ࣮ࢫࡸ⢾໬≀3-deoxyglucosone㈇Ⲵࢩࣗ࣡ࣥ⣽⬊ᰴ
IFRS1࡟࠾࠸࡚Ⓨ⌧ㄏᑟࡉࢀࡿື≀ࣞࢡࢳࣥgalectin-3ࡣࠊ⣽⬊ ಖ ㆤ ⓗ ࡟ స ⏝ ࡍ ࡿ ྍ ⬟ ᛶ ࡀ ♧ ၀ ࡉ ࢀ ࡓ (Neurosci Res
2015)ࠋ࣭ ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊ᰴࢆ㧗ࢢࣝࢥ࣮ࢫ࣭እᅉᛶࣆࣝࣅ
ࣥ㓟Ḟኻ⎔ቃୗ࡟ᭀ㟢ࡍࡿ࡜ࠊゎ⢾⣔࣭ࢡ࢚ࣥ㓟ᅇ㊰ࢆ௓ࡋࡓ࢚ࢿࣝࢠ࣮௦ㅰࡀⴭࡋࡃᢚไࡉࢀࡿ࡜࡜ࡶ࡟ࠊᑠ⬊యࢫࢺࣞࢫ࣭㓟໬ࢫࢺࣞࢫࡀㄏᑟࡉࢀࠊ▷᫬㛫࡛㢧ⴭ࡞⣽⬊Ṛࡀぢࡽࢀࡓ 㸦ඵᏊ, 2017᪥ᮏ⑓ែ⏕⌮Ꮫ఍◊✲ዡບ㈹ཷ㈹)ࠋ
࣭ exendin-4࡟ࡼࡿ㍈⣴ఙ㛗ಁ㐍࣭⚄⤒⣽⬊⏕Ꮡ⥔ᣢస⏝࡟ࠊPI3
kinase⤒㊰ࢆ௓ࡋࡓ෌⏕㜼ᐖᅉᏊRhoAάᛶࡢᢚไࡀ㛵୚ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ (Histochem Cell Biol 2015)ࠋ
࣭ ࢔࣑ࣟ࢖ࢻ࣏ࣜࢽ࣮ࣗࣟࣃࢳ࣮ࡸ࢔࣑࢜ࢲࣟࣥ࡟ࡼࡿ⬺㧊ᛶࢽ࣮ࣗࣟࣃࢳ࣮ࡢᇵ㣴⣔ࣔࢹࣝࢆ☜❧ࡋࡓ (J Neurochem 2015;
Eur J Neurosci 2016)ࠋ
࣭ ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไࢱࣥࣃࢡ㉁RubiconࡢⓎ⌧ᢚไࡣࠊ⚄⤒ኚᛶ ⑌ ᝈ ࣔ ࢹ ࣝ ࢩ ࣙ ࢘ ࢪ ࣙ ࢘ ࣂ ࢚ ࡢ ⑕ ≧ ࢆ ᨵ ၿ ࡋ ࡓ (NatCommun 2019;኱ሙ, 2018᪥ᮏ⑓ែ⏕⌮Ꮫ఍◊✲ዡບ㈹ཷ㈹) ࠋ(1)

ᴫせ࣭ ࣏࣮ࣜ࢜ࣝ௦ㅰஹ㐍ࠊ⢾໬ࠊ㓟໬ࢫࢺࣞࢫ➼ࢆ௓ࡋࡓ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢⓎ⑕ᶵᵓゎ᫂
࣭ */3íཷᐜయసື⸆exendin-4ࡢ⚄⤒ಖㆤస⏝ࡢᶵᵓゎ࣭᫂ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓࠊ⢾ᒀ⑓࡟ࡼࡿ⚄⤒ኚᛶᶵᵓゎ࣭᫂ 㛵㐃ࡍࡿᮎᲈ⚄⤒㞀ᐖࡸㄆ▱⑕ࡢ⑓ែゎ᫂

(1)

E

◊
 ✲
ᮇ
  㛫࣭  ◊✲  ⪅ྡ  ➼
(2) ◊✲⪅ྡ୕஬୍᠇㸦་Ꮫ◊㸧㕥ᮌ࣐ࣜ㸦་Ꮫ◊㸧ඵᏊⱥྖ㸦་Ꮫ◊㸧ຍ⸨ᏹ୍㸦ឡ▱Ꮫ㝔኱㸧ᮧୖ㱟ᩥ㸦ᕝᓮ་኱㸧ᒣෆ῟ྖ㸦ᮾி⸆⛉኱㸧

(1)

◊✲ᮇ㛫
2015ᖺ4᭶㹼2020ᖺ3᭶
㸦5ᖺ㛫㸧

A

E

㸰㸮㸯㸷ᖺ㸱᭶㸱㸯᪥⌧ᅾ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢᡂᅉゎ᫂࡜἞⒪ᡓ␎㸭⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࣉࣟࢪ࢙ࢡࢺ
㸦ࣉࣟࢪ࢙ࢡࢺ࣮ࣜࢲ࣮㸸୕஬୍᠇㸧◊       ✲       ᡂ       ᯝ㸦◊✲௦⾲⪅ྡ㸧◊✲ㄢ㢟ྡ◊  ✲  ෆ  ᐜ୺࡞◊✲ᡂᯝ ◊✲άື 㸦2018 ᖺᗘ㸧㸲㸬㸰㸮㸯㸶ᖺᗘ ◊✲ᴗ⦼ࣉࣟࢪ࢙ࢡࢺྡ

ࢤࣀ࣒ືែࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

Masai, H., Fukatsu, R., Kakusho, N., Kanoh, Y., Moriyama, K., Ma, Y., Iida, K., Nagasawa, K.
(2019) Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding andoligomerization activities Scientific Reports, in press

2.

Kobayashi, S.*, Fukatsu, R.*, Kanoh, Y.*, Kakusho, N., Matsumoto, S., Chaen, S. and Masai, H.
(2019) "Both a unique motif at the C terminus and N-terminal HEAT repeat contribute to G4 binding
and origin regulation by Rif1 protein." Mol. Cell. Biol. pii: e00364-18. (* equal contribution)

3.

Masai, H., Kakusho, N., Fukatsu, R., Ma, Y., Iida, K., Kanoh, Y. and Nagasawa, K. (2018)"Molecular architecture of G-quadruplex structures generated on duplex Rif1 binding sequences."
J. Biol. Chem. 293, 17033-17049.

4.

Moriyama, K., Yoshizawa-Sugata, N., and Masai, H. (2018) "Oligomer formation and G-quadruplex
binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture." J.
Biol. Chem. 293, 3607-3624.

5.

Iguchi, T., Miyauchi, E., Watanabe, S., Masai, H. and Miyatake. S. (2018) "A BTB-ZF protein,
ZNF131, is required for early B cell development. Biochemical and Biophysical ResearchCommunications, 501, 70-575.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧㸦ⱥᩥ⥲ㄝ㸧
1.

Masai, H., Kanoh, Y., Moriyama, K., Yamazaki, S., Yoshizawa, N., and Matsumoto, S. (2018)"Telomere binding factors in regulation of DNA replication." Genes & Genetic Systems, 92, 119125 (Review) 㸦ᰝㄞ᭷㸧

2.

Ghadiri, H. Alavi, S., Dabirmanesh, B., Moriyama, K., Khajeh, K. and Masai, H. (2018) "Study Break: Cell
Timer/Cell Clock." Iran Biomed J. 2018 Sep 16. [Epub ahead of print] PubMed PMID: 30218996.

㸦࿴ᩥ⥲ㄝ㸧
1.

ṇ஭ஂ㞝ࠕᚤ⏕≀ࡢࢤࣀ࣒」〇ࡢࢫࢺࣛࢸࢪ࣮ࠖ ⏕≀ࡢ⛉Ꮫ 㑇ఏ ➨ 74 ྕ pp375-381.
(2018) 㸦ᰝㄞ᭷㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 9 ௳㸧1.

ṇ஭ஂ㞝㸦௚ 13 ྡ㸧 ࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀㸸ㅖลࡢ๢ࡢࢤࣀ࣒᝟ሗ ࣮࣡ࢡࢩࣙࢵࣉ ᰁⰍయࢲ࢖ࢼ࣑ࢡࢫࢆ⤫ྜⓗ࡟ไᚚࡍࡿ᪂ࡓ࡞ࢤࣀ࣒ࢩࢢࢼࢳ࣮ࣕ ⏕࿨⛉Ꮫ⣔Ꮫ఍ྜྠᖺḟ኱఍㸦ConBio2017㸧 2018.12.6㹼12.9 ⚄ᡞ࣏࣮ࢺ࢔࢖ࣛࣥࢻ රᗜ┴⚄ᡞᕷ－ 37 －

2.

ṇ஭ஂ㞝 ࠕDNA 」〇◊✲࠿ࡽࡦࡶ࡜ࡃࢤࣀ࣒ࡢㅦ㹼ᜠᖌ ᪂஭㈼୍ඛ⏕࡟ᑟ࠿ࢀ࡚㹼ࠖࣛࣥࢳࣙࣥࢭ࣑ࢼ࣮ 2018.11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

3.

Hisao Masai “From mechanisms of primer RNA synthesis to revelation of hidden messages ofgenome” OKAZAKI Fragment Memorial Symposium: Celebrating the 50th anniversary of the
discontinuous DNA replication model”, December 17㹼18, 2018 Nagoya University, Nagoya,
Aichi.

4.

Hisao Masai 㸦௚ 11 ྡ㸧 “RNA-DNA hybrid and G-quadruplex: exploring their biologicalsignificance as new genome signature” ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ ࣮࣡ࢡࢩࣙࢵࣉ ࠗ㠀ᶆ‽ᆺ᰾㓟ᙧែࡢ⏕⌮࣭⑓⌮࡜ࡑࡢไᚚ࠘ 2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

5.

You, Z. “Biochemistry of Mcm, the central factor for DNA replication: a hetelro-hexameric helicase
core complex that does not show DNA helicase activity.” 㤳㒔኱Ꮫᮾிࣂ࢖࢜ࢥࣥࣇ࢓ࣞࣥࢫ
2018 㤳㒔኱Ꮫᮾி 2018.11.16 ᮾி㒔

6.

ṇ஭ஂ㞝㸦௚ 3 ྡ㸧 “Roles of Claspin-Cdc7 in initiation and checkpoint activation: differentialfunctions of Cdc7 in cancer and normal cells” 3R&3C Symposium, November 12 㹼 16,
2018Kanazawa, Japan.

7.

ṇ஭ஂ㞝ࠕࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀ࡢ⣽⬊ෆືែ࡜⏕≀Ꮫⓗព⩏ࡢゎ᫂࡟ࡴࡅ࡚:DNA 」〇ไᚚ࡟࠾ࡅࡿᶵ⬟ࠖ ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࣒࢘ࠗ㑇ఏ᝟ሗࡢ⥔ᣢ⥅ᢎ࡟࠾ࡅࡿ࣑ࢡࣟ࡜࣐ࢡࣟࡢ⤫ྜⓗ⌮ゎ㸸⏕໬Ꮫࡢ᪂ࡓ࡞ᣮᡓ࠘ 2018.9.25 ி㒔ᗓ8.

⏣୰༟㸦௚ 4 ྡ㸧ࠕ኱⭠⳦ᰁⰍయࡢ oriC-DnaA 㠀౫Ꮡᛶ」〇㛤ጞ࡟ᚲせ࡜ࡉࢀࡿࢤࣀ࣒㓄ิ࡜ࡑࡢᶵ⬟ࠖ᪥ᮏ㑇ఏᏛ఍࣮࣡ࢡࢩࣙࢵࣉࠗከᵝ࡞ࣔࢹࣝཎ᰾⏕≀ࡢゎᯒ࠿ࡽぢ࠼࡚ࡃࡿ㑇ఏ᝟ሗ」〇࣭⥅ᢎࡢඹ㏻ཎ⌮࡜ከᵝᛶ࠘ 2018.9.19㹼9.21 ዉⰋඛ➃኱Ꮫ ዉⰋ┴

9.

Hisao Masai “G-quadruplexes: in vivo regulations and biological functions” THE 3RD
TRANSMED-VN CONFERENCE 2018 University of Medicine & Pharmacy (UMP), August 1920, 2018, HCM City – Vietnam.

ࡑࡢ௚ 㸦ィ 16 ௳㸧⮬⏤ᥖ㍕
1.

Sagi, T., Seki, Y., Tanaka, T. and Masai, H. “Genome-wide Profiles of RNA-DNA Hybrid and Gquadruplex in E.coli and Its Implication in An Alternative Mode of Chromosome Replication”
OKAZAKI Fragment Memorial Symposium: Celebrating the 50th anniversary of the discontinuous
DNA replication model Nagoya University, December 17㹼18, 2018. Nagoya, Aichi.

2.

Hori, K., Iguchi, T., Kobayashi, S. and Masai, H. “Roles of Cdc7 kinase complex in brain
development.” OKAZAKI Fragment Memorial Symposium: Celebrating the 50th anniversary of the
discontinuous DNA replication model, December 17㹼18, 2018. Nagoya University, Nagoya, Aichi.

3.

ຍ⣡㇏ࠊᯇᮏΎ἞ࠊ㜝ཱྀ┤ᶞࠊᑠᯘಇ௓ࠊ῝ὠ⌮஀ࠊ㮜ṇ┤Ꮚࠊṇ஭ஂ㞝 ࠕRif1 ࡢ⤖ྜᶆⓗ࡛࠶ࡿࢢ࢔ࢽࣥ㸲㔜㙐ᵓ㐀ࡢ⣽⬊ෆᏑᅾ࡜ᙧᡂࡢ࣓࢝ࢽࢬ࣒ࠖ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍࣮࣡ࢡࢩࣙࢵࣉࠗぢ࠼࡚ࡁࡓ㸟ࣇࣞ࢟ࢩࣈ࡛ࣝࢲ࢖ࢼ࣑ࢵࢡ࡞ࢤࣀ࣒⥔ᣢᶵᵓࡢࡍ
ࡀࡓ࠘2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ㸦ཱྀ㢌Ⓨ⾲㸧

4.

ྜྷἑ┤Ꮚࠊṇ஭ஂ㞝 ࠕࢡ࣐ࣟࢳࣥ㧗ḟᵓ㐀࣮࢜࢞ࢼ࢖ࢨ࣮Rif1 ࡢᢚไ࡟ࡼࡾㄏᑟࡉࢀࡿࠊ
2 ⣽⬊ᮇ⬇ᵝ࣐࢘ࢫ ES ⣽⬊ࡢ୙ᆒ୍࡞᰾ෆᵓ㐀ኚ໬ࠖ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍࣮࣡
ࢡࢩࣙࢵࣉ ࠗࢡ࣐ࣟࢳࣥࡢࡶࡘ₯ᅾⓗ࡞㑇ఏᏊᶵ⬟ไᚚࡢศᏊᶵᵓ࠘ 2018.11.28㹼11.30⚄ዉᕝ┴ᶓ὾ᕷ 㸦ཱྀ㢌Ⓨ⾲㸧

－ 38 －

5.

᳃ᒣ㈼἞ࠊྜྷἑ┤Ꮚࠊṇ஭ஂ㞝ࠕ࣐࢘ࢫ Rif1 ࢱࣥࣃࢡ㉁ࡢ㸰ࡘࡢࢢ࢔ࢽࣥ㸲㔜㙐 DNA ⤖ྜࢻ࣓࢖ࣥࡢྠᐃࠖ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

6.

᳿඼㥴ࠊຍ⸨ᏹᖾࠊ㐍⸨┿⏤⨾ࠊṇ஭ஂ㞝ࠕCdc7 ࢟ࢼ࣮ࢮࡣ」〇ࢫࢺࣞࢫ௰௓ศᏊ Claspinࡢ CKBD㸦Chk1 ⤖ྜࢻ࣓࢖ࣥ㸧ࡢࣜࣥ㓟໬ࢆ௓ࡋ࡚ࢳ࢙ࢵࢡ࣏࢖ࣥࢺࢆάᛶ໬ࡍࡿࠖ➨41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ7.

ᑠᯘ 㥴௓ࠊ῝ὠ ⌮஀ࠊຍ⣡ ㇏ࠊむṇ ┤Ꮚࠊᯇᮏ Ύ἞ࠊṇ஭ ஂ㞝ࠕࢢ࢔ࢽࣥ㸲㔜㙐⤖ྜࢱ
ࣥࣃࢡ㉁ Rif1 ࡢᵓ㐀࣭ᶵ⬟ゎᯒࠖ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

8.

㮛᭸Ꮚࠊ⏣୰༟ࠊṇ஭ஂ㞝ࠕRNA-DNA hybrid ࡟౫Ꮡࡋࡓ኱⭠⳦ࡢ➨஧ࡢ」〇⣔ࡢ㛤ጞᶵᵓࡢゎᯒࠖ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

9.

ᯇᮏΎ἞ࠊຍ⣡㇏ࠊ᪂ᮏ⨾ᬛᯞࠊୖ㔝຾ࠊ᪩㔝ඖႹࠊᕤ⸨㔛⨾ࠊṇ஭ஂ㞝ࠕRif1 㐣๫Ⓨ⌧ࡣᰁⰍయศ㓄ࡢ㞀ᐖࢆㄏᑟࡋࠊM ᮇ㐍⾜ࢆ㜼ᐖࡍࡿࠖ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍
2018.11.28㹼11.30 ⚄ዉᕝ┴ᶓ὾ᕷ

10. Chi-Chung Yang, Hiroyuki Kato, Mayumi Shindo, and Hisao Masai “Roles of Claspin-Cdc7 ininitiation and checkpoint activation: differential functions of Cdc7 in cancer andnormal cells”
3R&3C Symposium, November 12㹼16, 2018, Kanazawa, Japan
11. Yutaka Kanoh, Seiji Matsumoto, and Hisao Masai “Genetic analysis of origin suppression by Fission
yeast Rif1: roles of chromatin binding through G-quadruplex” 3R&3C Symposium, , November 12
㹼16, 2018, Kanazawa, Japan
12. Shunsuke Kobayashi, Rino Fukatsu, Yutaka Kanoh, Naoko Kakusho, Seiji Matsumoto, Hisao Masai“Analysis of function and structure of G4 binding domain of fission yeast Rif1 protein” 3R&3C
Symposium, November 12㹼16, 2018, Kanazawa, Japan.
13. Hisao Masai, Rino Fukatsu, Naoko Kakusho, Yutaka Kanoh, Kenji Moriyama, Yue Ma, Keisuke
Iida, Kazuo Nagasawa “Rif1 promotes self-association of G-quadruplex (G4) by it specific G4
binding and oligomerization activities” 3R&3C Symposium, November 12㹼16, 2018, Kanazawa,
Japan.
14. ṇ஭ஂ㞝 㑇ఏ᝟ሗࡢ⥔ᣢ⥅ᢎ࡟࠾ࡅࡿ࣑ࢡࣟ࡜࣐ࢡࣟࡢ⤫ྜⓗ⌮ゎ㸸⏕໬Ꮫࡢࡓࡵࡢ᪂
ࡓ࡞ᣮᡓ ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ኱఍ 2018.9.24㹼9.26 ᅜ❧ி㒔ᅜ㝿఍㤋 ி㒔ᗓ
15. Masai Hisao, RNA-DNA hybrid and G-quadruplex : exploring their biological significance as new
genome signatures, 2018.8.19㹼8.20 Ho Chi Minh,Vietnam
16. Yuko Takai,  The intramolecular interaction mechanism of human Claspin activation,

DNA

Metabolism, Genomic, Stability & Human Disease, 2018.6.11㹼6.15 Suzhou,Chaina
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 9 ௳㸧1.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒࡜⚾ࡓࡕࡢ⏕άࠖ᪥ᮏ኱Ꮫᩥ⌮Ꮫ㒊බ㛤ㅮᗙ 2018ࠗ⏕࿨ࡣ୙ᛮ㆟࣑ࠥࢡࣟ࠿ࡽ࣐ࢡࣟࡢୡ⏺ࡲ࡛࠘᪥ᮏ኱Ꮫ ᮾி㒔ୡ⏣㇂༊ᱜୖỈ 2018.10.132.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒」〇ࡢ࣓࢝ࢽࢬ࣒࠿ࡽࢤࣀ࣒ไᚚࡢ᪂ࡋ࠸ཎ⌮ࡢⓎぢࢆࡵࡊࡍࠖឡ▱┴❧༙⏣㧗➼Ꮫᰯ㸦◊✲ᡤゼၥ㸧 2018.7.31

3.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒」〇ࡢ࣓࢝ࢽࢬ࣒࠿ࡽࢤࣀ࣒ไᚚࡢ᪂ࡋ࠸ཎ⌮ࡢⓎぢࢆࡵࡊࡍࠖ᪥ᮏ
኱Ꮫᩥ⌮Ꮫ㒊⏕࿨⛉Ꮫ⛉㸦◊✲ᡤゼၥ㸧 2018.7.25

4.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒」〇ࡢ࣓࢝ࢽࢬ࣒࠿ࡽࢤࣀ࣒ไᚚࡢ᪂ࡋ࠸ཎ⌮ࡢⓎぢࢆࡵࡊࡍࠖᖹᡂ

－ 39 －

30 ᖺᗘ S ࢭ࣓ࢫࢱ࣮ࠕ඲Ꮫయ㦂ࢮ࣑ࢼ࣮ࣝࠖᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ 㸦ᮾி኱Ꮫᩍ㣴Ꮫ㒊㸧
2018.7.1
5.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒ࡢ⥅ᢎ࣭⥔ᣢ࣭ᶵ⬟Ⓨ⌧ࡢ᪂ཎ⌮ࡢゎ᫂ࢆ┠ᣦࡋ࡚ࠖ࠾ⲔࡢỈዪᏊ኱Ꮫ⌮Ꮫ㒊⏕≀Ꮫ⛉ ᖹᡂ 30 ᖺᗘ⏕࿨⛉Ꮫ≉Ṧㅮ⩏ VI ࠾ⲔࡢỈ኱Ꮫ 2018.6.29ࠊ6.21

6.

ṇ஭ஂ㞝 ࠕ᰾㓟ࡢᙧࡀไᚚࡍࡿࢤࣀ࣒ᶵ⬟㸸⣽⬊ࡢቑṪࠊ㐠࿨ࢆỴᐃࡍࡿᰁⰍయࢲ࢖ࢼ
࣑ࢡࢫࡢไᚚᶵᵓࠖᮾி⌮⛉኱Ꮫ⌮ᕤᏛ㒊ᛂ⏝⏕≀⛉Ꮫ⛉ࠕ⏕࿨ືែᏛࠖ2018.6. 14

7.

ṇ஭ஂ㞝 ࠕDNA ࡢᙧࡀไᚚࡍࡿࢤࣀ࣒ᶵ⬟࡜⑌ᝈࠖᮾி኱Ꮫ᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉ ࣓ࢹ࢕࢝ࣝ᝟ሗ⏕࿨ㅮ⩏Ⓨᒎㅮ⩏ IV 2018.6.8

8.

ṇ஭ஂ㞝 ࠕࢤࣀ࣒ࡢ⥅ᢎ࣭⥔ᣢ࣭ᶵ⬟Ⓨ⌧ࡢ᪂ཎ⌮ࡢゎ᫂ࢆ┠ᣦࡋ࡚ࠖᮾி኱Ꮫ⌮Ꮫ㒊⏕≀໬Ꮫ⛉ ᖹᡂ 30 ᖺᗘ S ࢭ࣓ࢫࢱ࣮ࠕ⣽⬊ศᏊ⏕≀Ꮫ 1ࠖ ᮾி኱Ꮫ ᮾி㒔ᩥி༊ᮏ㒓 2018.6. 6ࠊ5.23ࠊ5.99.

ṇ஭ஂ㞝 ᮾிࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮ᑓ㛛Ꮫᰯ㸦◊✲ᡤゼၥ㸧 2018.5.31ࠊ5.9

IV. ≉グ஦㡯－ 40 －

ࣉࣟࢪ࢙ࢡࢺྡ

့ங㢮㑇ఏࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Matsuoka K, Wada K, Miyasaka Y, Yasuda SP, Seki Y, Nishito Y, Yonekawa H, Taya C, Shitara H,
Kikkawa Y: OHC-TRECK: A novel system using a mouse model for investigation of the molecularmechanisms associated with outer hair cell death in the inner ear. Sci Rep, 9:5285, 2019ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1.

Yasuda SP, Miyasaka Y, Kikkawa Y: Effects of genetic background on susceptibility and theacceleration of hearing loss in mice. An Excursus into Hearing Loss (Edited by: S. Hatzopoulos),
InTechOpen, London, UK, 1, pp. 3–23, 2018.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

ྜྷᕝḠு㸸⾲⌧ᆺᙧᡂ࡟࠾ࡅࡿ㑅ᢥⓗࢫࣉࣛ࢖ࢩࣥࢢ࢔࢖ࢯࣇ࢛࣮࣒ࡢಶูᶵ⬟㸬㑇ఏ◊◊✲఍ࠕ࣐࢘ࢫ㑇ఏᏛ࣭ ᨾ▱᪂ࠖ
㸬2019. 3. 15 ᅜ❧㑇ఏᏛ◊✲ᡤ 㟼ᒸ┴୕ᓥᕷ

2.

Ᏻ⏣ಇᖹࠊ㛵ඃኴࠊ࿴⏣೺ኴࠊΏ㒊᱇ࠊᗜᮏ㧗ᚿࠊ┿ୗ▱ኈࠊタᴦᾈᚿࠊྜྷᕝḠு㸸㑇ఏᛶⓑෆ㞀Ⓨ⑕࡟࠾ࡅࡿ࣐࢘ࢫ࣭ࣛࢵࢺ㛫ࡢẚ㍑ゎᯒ㸬࣮࣡ࢡࢩࣙࢵࣉ 3PW-10ࠕ࣐࢘ࢫ࡜
ࣛࢵࢺࡢẚ㍑ᐇ㦂ື≀Ꮫ࡛᥈ࡿ㑇ఏᏊࡢ᪂ࡓ࡞ᶵ⬟ࠖ㸬➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍
2018. 11. 30 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ┴ᶓ὾ᕷࡑࡢ௚ 㸦ィ 11 ௳㸧⮬⏤ᥖ㍕
1.

ྜྷᕝḠுࠊᏳ⏣ಇᖹࠊ㛵ඃኴࠊᯇᒸ㑥ᯞ㸸࣐࢘ࢫ࢝ࢻ࣊ࣜࣥ 23 ከᆺࡢ㞴⫈Ⓨ⑕࡬ࡢຠᯝࡢ᳨ド㸬➨ 28 ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ 2018. 10. 4 ኱㜰ᅜ㝿఍㆟ሙ ኱㜰ᗓ 

2.

㛵ඃኴࠊᏳ⏣ಇᖹࠊᯇᒸ㑥ᯞࠊྜྷᕝḠு㸸Myosin VI ኚ␗࣐࢘ࢫࡢ୙ືẟ⼥ྜ㐣⛬࡟ㄆࡵࡽࢀࡿ᭷ẟ⣽⬊㡬㒊ࡢ≉ᚩⓗ࡞⾲⌧ᆺ㸬 ➨ 28 ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ 2018.
10. 4 ኱㜰ᅜ㝿఍㆟ሙ ኱㜰ᗓ3.

ྜྷᕝḠுࠊ࿴⏣೺ኴࠊΏ㒊᱇ࠊᯇᓥⰾᩥࠊタᴦᾈᚿࠊΎᮎඃᏊ㸸Ỉᬗయ⬺⮻ⓑෆ㞀ࣔࢹࣝ
࣐࢘ࢫࡢⓎ⑕ཎᅉ࡜࡞ࡿ Phldb1 ࡢ 1 ሷᇶᤄධኚ␗㸬➨ 57 ᅇ᪥ᮏⓑෆ㞀Ꮫ఍⥲఍࣭➨ 44ᅇỈᬗయ◊✲఍ 2018. 7. 21 ▼ᕝ┴❧㡢ᴦᇽ ▼ᕝ┴㔠ἑᕷ

4.

Ᏻ⏣ಇᖹࠊ㛵ඃኴࠊΏ㒊᱇ࠊ࿴⏣೺ኴࠊᗜᮏ㧗ᚿࠊ┿ୗ▱ኈࠊྜྷᕝḠு㸸ࣛࢵࢺ Mip ࣑ࢫࢭࣥࢫኚ␗ࡢ࣍ࣔ᥋ྜయࡣᑠ║⌫⑕ࢆㄏᑟࡍࡿ㸬➨ 57 ᅇ᪥ᮏⓑෆ㞀Ꮫ఍⥲఍࣭➨ 44 ᅇỈᬗయ◊✲఍ 2018. 7. 21 ▼ᕝ┴❧㡢ᴦᇽ ▼ᕝ┴㔠ἑᕷ

5.

࿴⏣೺ኴࠊᩪ⸨₶୍ࠊᒣཱྀ☐ࠊ㛵ඃኴࠊ㧗ᶫ๛ࠊタᴦᾈᚿࠊྜྷᕝḠு㸸Pde6brd1 ࡣ Foxe3rct－ 41 －

ࡢⓑෆ㞀ࢆ㔜⠜໬ࡉࡏࡿಟ㣭㑇ఏᏊኚ␗࡛࠶ࡿ㸬➨ 57 ᅇ᪥ᮏⓑෆ㞀Ꮫ఍⥲఍࣭➨ 44 ᅇỈᬗయ◊✲఍ 2018. 7. 21 ▼ᕝ┴❧㡢ᴦᇽ ▼ᕝ┴㔠ἑᕷ
6.

㛵ඃኴࠊタᴦᾈᚿࠊྜྷᕝḠு㸸࣐࢘ࢫ⫈ຊ࡟࠾ࡅࡿ࣑࢜ࢩࣥ VI 㑇ఏᏊࡢኚ␗࢔ࣞࣝࡢࢻ
࣑ࢼࣥࢺຠᯝ㸬➨ 31 ᅇࣔࣟࢩࢾࢫ◊✲఍ 2018. 6. 23 ໭ᾏ㐨኱Ꮫ ໭ᾏ㐨ᮐᖠᕷ

7.

Ᏻ⏣ಇᖹࠊᑠཎኸࠊ㕥ᮌἋ⌮ࠊ౳㞷ྵࠊ࿴⏣೺ኴࠊ㧗⏣㇏⾜ࠊᇛ▼ಇᙪࠊ᪂ᾏ඾ኵࠊTony
Kuoࠊ℩ࠎ₶ࠊྜྷᕝḠு㸸࢝ࢻ࣊ࣜࣥ 23 ኚ␗࡜┦ຍⓗ࡟స⏝ࡍࡿ B6J ࣐࢘ࢫࡢຍ㱋ᛶ㞴⫈ಟ㣭㑇ఏᏊࡢ᥈⣴㸬➨ 31 ᅇࣔࣟࢩࢾࢫ◊✲఍ 2018. 6.23 ໭ᾏ㐨኱Ꮫ ໭ᾏ㐨ᮐᖠᕷ

8.

Ᏻ⏣ಇᖹࠊΏ㒊᱇ࠊ࿴⏣೺ኴࠊᗜᮏ㧗ᚿࠊ┿ୗ▱ኈࠊྜྷᕝḠு㸸ⓑෆ㞀Ⓨ⑕㈐௵㑇ఏᏊ Mip
ࡢ 1 ࢔࣑ࣀ㓟⨨᥮ࡣࣛࢵࢺࡢᑠ║⌫ࢆㄏᑟࡍࡿ㸬 ➨ 65 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2018.
5. 17 ᐩᒣ┴Ẹ఍㤋 ᐩᒣ┴

9.

㛵ඃኴࠊタᴦᾈᚿࠊᐑᆏຬ㍤ࠊ㕥ᮌἋ⌮ࠊᏳ⏣ಇᖹࠊྜྷᕝḠு㸸࣐࢘ࢫ Myosin VI Ḟᦆ࢔ࣞࣝ࣊ࢸࣟ᥋ྜయࡀ⏕ࡌࡿ⫈ຊ㞀ᐖ㸬➨ 65 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2018. 5. 17 ᐩᒣ┴Ẹ఍㤋 ᐩᒣ┴10. ᯇᒸ㑥ᯞࠊᏳ⏣ಇᖹࠊ࿴⏣೺ኴࠊᐑᆏຬ㍤ࠊタᴦᾈᚿࠊከᒇ㛗἞ࠊྜྷᕝḠு㸸ㄏᑟᆺ◚ቯ࣐࢘ࢫࢆ⏝࠸ࡓෆ⪥እ᭷ẟ⣽⬊࡟࠾ࡅࡿᶵ⬟㑇ఏᏊࡢྠᐃ㸬➨ 65 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲
఍ 2018. 5. 17 ᐩᒣ┴Ẹ఍㤋 ᐩᒣ┴
11. ྜྷᕝḠுࠊᐑᆏຬ㍤ࠊᏳ⏣ಇᖹࠊ㕥ᮌἋ⌮ࠊ㛵ඃኴࠊタᴦᾈᚿ㸸Lrrc30 ࡢⓎ⌧㔞ቑຍࡣ࣐࢘ࢫຍ㱋ᛶ㞴⫈ࡢⓎ⑕ࢆഹ࠿࡟ᢚไࡍࡿ㸬➨ 65 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ 2018. 5. 17 ᐩᒣ┴Ẹ఍㤋 ᐩᒣ┴

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯࠙Ꮫ⾡άືࠚ
1.

ྜྷᕝḠு ᪥ᮏᐇ㦂ື≀Ꮫ఍ホ㆟ဨࠊ᪥ᮏᐇ㦂ື≀Ꮫ఍Ꮫ⾡㞟఍ጤဨࠊ⌮໬Ꮫ◊✲ᡤࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ࣜࢯ࣮ࢫ᳨ウጤဨ఍ጤဨ࣭ࣞࣅ࣮ࣗጤဨ఍ጤဨࠊ➨ 65 ᅇ᪥ᮏᐇ㦂ື≀Ꮫ఍⥲఍ࣉࣟࢢ࣒ࣛ⦅㞟ጤဨࠊࣔࣟࢩࢾࢫ◊✲఍ᖿ஦ࠊ໭ᾏ㐨ᐇ㦂ື≀◊✲఍ᖿ஦ࠊ࠙ᩍ⫱άືࠚ
1.

ྜྷᕝḠு ᪂₲኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉ᐈဨᩍᤵ㸦༤ኈㄢ⛬ 1 ྡ࠾ࡼࡧಟኈㄢ⛬ 1 ྡᣦᑟ㸧

࠙㈹⨩ࠊ〔❶ࠚ1.

ྜྷᕝḠு ➨ 57 ᅇ᪥ᮏⓑෆ㞀Ꮫ఍⥲఍࣭➨ 44 ᅇỈᬗయ◊✲఍ඃ⚽₇㢟㈹－ 42 －

ࣉࣟࢪ࢙ࢡࢺྡ

ឤᰁไᚚࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

Sanada T, Yasui F, Honda T, Kayesh MEH, Takano J, Shiogama Y, Yasutomi Y, Tsukiyama-Kohara
K, Kohara M. Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree
shrew (Tupaia belangeri). Virology. 529: 101-110 (2019)2.

Imada T, Moriya K, Uchiyama M, Inukai N, Hitotsuyanagi M, Masuda A, Suzuki T, Ayukawa S,
Tagawa YI, Dohmae N, Kohara M, Yamamura M, Kiga D. A Highly Bioactive Lys-Deficient IFN
Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFNĮb. ACS Synth Biol. 7(11):2537-2546 (2018)3.

Okamoto M, Fukushima Y, Kouwaki T, Daito T, Kohara M, Kida H, Oshiumi H. MicroRNA-451a
in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses toinfluenza whole-virus vaccine. J Biol Chem. 293(48) 18585̽18600 (2018)4.

Cheng L, Wang Q, Li G, Banga R, Ma J, Yu H, Yasui F, Zhang Z, Pantaleo G, Perreau M, Zurawski
S, Zurawski G, Levy Y, Su L. TLR3 agonist and CD40-targeting vaccination induces immune
responses and reduces HIV-1 reservoirs. J Clin Invest. 128(10):4387-4396 (2018)

5.

Nishitsuji H, Harada K, Ujino S, Zhang J, Kohara M, Sugiyama M, Mizokami M, Shimotohno K.
Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses. Cancer
Sci. 109(1):241-249 (2018)ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1.

Kitab B, Kohara M, Tsukiyama-Kohara K. Experimental in vitro and in vivo systems for studying
the innate immune response during dengue virus infections. Arch Virol. 2018 Jul;163(7):1717-1726.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1. ᑠཎ㐨ἲ㸸ࠕච␿άᛶ໬࡟ࡼࡿ C ᆺ⫢⅖࢘࢖ࣝࢫ᤼㝖ࢆ┠ᣦࡋ࡚ࠖ ➨ 14 ᅇᗈᓥ⫢⮚ࣉࣟࢪ࢙ࢡࢺࢩ࣏ࣥࢪ࣒࢘ 2018.7.7 ࣍ࢸࣝࢢࣛࣥࣅ࢔ᗈᓥ
2. ᑠཎ㐨ἲ㸸ࠕWnt/ȕ-catenin ࢩࢢࢼࣝఏ㐩⤒㊰㜼ᐖ๣࡟ࡼࡿ⫢◳ኚ⑕࠿ࡽࡢ㞳⬺ཬࡧ⫢⣽⬊ᶵ⬟෌⏕ࠖ ➨ 13 ᅇᅄᅜ⫢⑌ᝈ◊✲఍ 2018.6.22 ᯇᒣ඲᪥✵࣍ࢸࣝࡑࡢ௚ 㸦ィ 22 ௳㸧⮬⏤ᥖ㍕
1.

ᒣᆅ㈼୕㑻 ࢝ࢽࢡ࢖ࢨ࡛ࣝࡢ H7N9 㫽࢖ࣥࣇ࢚ࣝࣥࢨ HA ࢱࣥࣃࢡ㉁Ⓨ⌧⤌᥮࠼࣡ࢡࢩ
ࢽ࢔࣡ࢡࢳࣥࡢⓎ⑕㜵ᚚຠᯝࡢ᳨ウ ➨ 22 ᅇ᪥ᮏ࣡ࢡࢳࣥᏛ఍Ꮫ⾡⥲఍ 2018.12.8㹼

－ 43 －

12.9 ⚄ᡞᅜ㝿఍㤋 රᗜ┴⚄ᡞᕷ
2.

ᑠཎ㐨ἲ ᪂つ HBs-Lh ᢠཎཬࡧ CVP ᇶᮦే⏝㍍ᚤᢞ୚࡟ࡼࡾ㑇ఏᏊᆺ஺ᕪ཯ᛂᛶࡢ㧗࠸୰࿴ᢠయཬࡧ IgA ᢠయࡢ⏘⏕ࡀ࡛ࡁࡿ ➨ 22 ᅇ᪥ᮏ࣡ࢡࢳࣥᏛ఍Ꮫ⾡⥲఍ 2018.12.8
㹼12.9 ⚄ᡞᅜ㝿఍㤋 රᗜ┴⚄ᡞᕷ

3.

Ლཎ┤ᶞ H5N1 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢࢩ࢔ࣝ㓟㈝౫Ꮡⓗ࡞⣽⬊౵ධ⤒㊰ࡢゎᯒ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ┴ᶓ὾ᕷ

4.

Ჷ᪉⩼ ࣉࣞࢤࣀ࣒ RNA ࢆᶆⓗ࡜ࡍࡿ࣐࢖ࢡࣟ RNA ࡟ࡼࡿ B ᆺ⫢⅖࢘࢖ࣝࢫࡢ」〇ಁ㐍➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ┴ᶓ὾ᕷ

5.

Bouchra Kitab  Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus byprotecting NS5B protein from hPLICI-dependent proteasomal degradation, ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28㹼11.30 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ┴ᶓ὾ᕷ
6.

Kenzaburou Yamaji

PRI-724, a selective inhibitor of Wnt/ȕ-catenin/CBP signaaaaling,ameliomates NASH-induced liver fibrosis,

AASLD The Liver Meeting 2018 2018.11.9㹼11.13

San Francisco,U.S.A.
7.

Osamu Yoshida 

A Nasal Administrative Therapeutic Vaccine(NASVAC) with Modified

Treatment Strategy Reduces and Eliminates Hbs Antigen in HBV Infected Patients with or without
Nucleos(+)Ide Analogs Therapy, AASLD The Liver Meeting 20182018.11.9 㹼 11.13  San

Francisco,U.S.A.
8.

Ჷ᪉⩼ E2F1 ࡟ࡼࡿ B ᆺ⫢⅖࢘࢖ࣝࢫࡢ㌿෗ไᚚ ➨ 66 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍
2018.10.28㹼10.30 ி㒔ࢸࣝࢧ ி㒔ᗓ9.

┿⏣ᓫᘯ HBs-large protein vaccination via intranasal route with carboxyl vinyl polymer induces
strong neutralizing antibody and anti-HBs lgA. ➨ 66 ᅇ ᪥ ᮏ ࢘ ࢖ ࣝ ࢫ Ꮫ ఍ Ꮫ ⾡ 㞟 ఍

2018.10.28㹼10.30 ி㒔ࢸࣝࢧ ி㒔ᗓ
10. ᒣ᰿኱඾ ࢖ࣥࢱ࣮ࣇ࢙ࣟࣥไᚚᅉᏊ 1 ࡣ MAVS 㠀౫Ꮡⓗ࡟⫢⮚ᣦྥᛶ RNA ࢘࢖ࣝࢫࡢ
」〇ࢆไᚚࡍࡿ ➨ 66 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2018.10.28㹼10.30 ி㒔ࢸࣝࢧி㒔ᗓ
11. Mohammad Enamul Hoque Kayesh

Development of in vivo delivery system of CRISPR/Cas9

targeting hepatitis virus, ➨ 66 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2018.10.28㹼10.30 ி㒔ࢸࣝࢧ ி㒔ᗓ
12. Yohei Miyayama Mechanistical study of antiviral actinity of snake venom sPLA2 against HBVand HCV, ➨ 66 ᅇ᪥ᮏ࢘࢖ࣝࢫᏛ఍Ꮫ⾡㞟఍ 2018.10.28㹼10.30 ி㒔ࢸࣝࢧ ி㒔ᗓ
13. Yuko Tokunaga

Intermittent administration of selective Wnt/ș-catenin/CBP signaling inhibitor

ameliorates hepatitis C virus-induced liver fibrosis, 25th International Synposium on Hapatitis C
Virus and Related Viruses 2018.10.8㹼10.11 Dublin, Ireland
14. Takahiro Sanada

HBs-large protein vaccination via intranasal route with carboxyl vinyl polymer

induces strong neutralizing antibody and anti-HBs lgA.
Molecular Biology of Hepatitis B Viruses

2018 International HBV Meeting : The

2018.10.3㹼10.6 Taormina,Italy

15. Tsubasa Munakata

Enhancement of hepatitis B virus replication by a microRNA targeting

pregenomic RNA.

2018 International HBV Meeting : The Molecular Biology of Hepatitis B

Viruses 2018.10.3㹼10.6 Taormina,Italy－ 44 －

16. Tomoko Honda

Essential Role for Serial Immune responses in Protection against Influenza H5N1

in Mice by an Attenuated Vaccinia Virus Vector Expressing Influenza Virus H5 HA, 12th Vaccine
Congress

2018.9.16㹼9.19 Budapest,Hungary

17. Fumihiko Yasui  Evaluation of vaccine potential of recombinant vaccinia virus encoding H5subtype hemagglutinin against H5N1 influenza viruses,

12th Vaccine Congress2018.9.16㹼

9.19 Budapest,Hungary
18. Yumi Shiogama

Effective Therapeutic Vaccine for Hepatitis C virus Infection by Heterologous

antigen Immuno-therapy, 12th Vaccine Congress2018.9.16㹼9.19 Budapest,Hungary

19. ❧㔝▱ୡ ࣄࢺᖿ⣽⬊࣓࣐࢟ࣛ࢘ࢫࢆ⏝࠸ࡓ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖ࣔࢹ࣐ࣝ࢘ࢫࡢ
⑓ែゎᯒ ➨ 25 㝵ᖿ⣽⬊◊✲఍ 2018.7.12㹼7.13 ᮾி኱Ꮫ ఀ⸨ᅜ㝿Ꮫ⾡◊✲ࢭࣥࢱ࣮
ᮾி㒔
20. Mohammad Enamul Hoque Kayesh Pathophysiology of hepatitis C virus and animal model, The
12th China-Japan International Conference of Virology 2018.5.17㹼5.19 Wuhan,China
21. Fumihiko Yasui Protective effect of a recombinant influenzavaccine against H5 subtype viruses
based on highly attenuated vaccinia virus vector, The 12th China-Japan International Conferenceof Virology 2018.5.17㹼5.19 Wuhan,China
22. Mohammad Enamul Hoque Kayesh Inhibition of hepatitis B virus replication by CRISPR/Cas9
system in vitro and in vivo,

6thJAPAN-TAIWAN-KOREA HBV Research Symposium 2018. 4.7

㹼4.8 Taipei, Taiwan
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯࠙≉チฟ㢪ࠚ
1.

Ⓨ᫂ࡢྡ⛠㸸㹀ᆺ⫢⅖࢘࢖ࣝࢫࡢ」〇㜼ᐖ⤌ᡂ≀ ձⓎ᫂⪅㸸Ჷ᪉⩼ࠊᑠཎ㐨ἲࠊ┿⏣ᓫᘯղฟ㢪᪥ 2018.11.16 ճฟ㢪␒ྕ㸸≉㢪 2018-215898 մฟ㢪ே㸸බ┈㈈ᅋἲே ᮾி㒔་Ꮫ
⥲ྜ◊✲ᡤ

2.

Ⓨ᫂ࡢྡ⛠㸸᪂ᆺ࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫ⏤᮶࣐࣊ࢢࣝࢳࢽࣥࢱࣥࣃࢡ㉁㑇ఏᏊࢆ᭷ࡍࡿ
DIs ᰴ⏤᮶⤌᥮࠼࣡ࢡࢩࢽ࢔࢘࢖ࣝࢫ ձⓎ᫂⪅㸸Ᏻ஭ᩥᙪࠊᑠཎ㐨ἲࠊᒣᆅ㈼୕㑻ࠊఀ⸨㟹ࠊᑠ➟ཎ୍ㄔࠊ▼஭Ꮥྖ ղฟ㢪᪥ 2018.11.14 ճฟ㢪␒ྕ㸸≉㢪 2018-213990 մฟ㢪ே㸸බ┈㈈ᅋἲே ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸹⁠㈡་⛉኱Ꮫ㸹ᅜ❧ឤᰁ⑕◊✲ᡤ－ 45 －

ࣉࣟࢪ࢙ࢡࢺྡ

࢘࢖ࣝࢫឤᰁࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S؊Amino acid variation at VP1145 of enterovirus 71 determines attachment receptor usage and neurovirulence in human scavenger
receptor B2 transgenic mice. J. Virol. 92: e00681-18, 2018㸦ᰝㄞ᭷㸧

2.

Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O,
Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y, Koike S: VP1 amino acid residue 145 ofenterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody
during cynomolgus monkey infection. J. Virol. 92: e00682-18, 2018㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 5 ௳㸧⮬⏤ᥖ㍕
1.

Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S: Use of attachment receptor,
heparan sulfate proteoglycan, negatively affects neurovirulence of VP1-145 variants of enterovirus
71. The 20 th Meeting of the European Study Group on the Molecular Biology of Picornaviruses(EUROPIC 2018) (2016.6. 5, Egmond an Zee, Netherlands)

2.

Koike S, Imura A, Sudaka Y, Takashino A, Kobayashi K, Fujii K, Nishimura H, Mizuta K:
Establishment of EV71 vaccine efficacy test using human scavenger receptor B2 transgenic mice
The 20 th Meeting of the European Study Group on the Molecular Biology of Picornaviruses(EUROPIC 2018) (2016.6. 6, Egmond an Zee, Netherlands)

3.

Kotani O, Yokoyama M, Fujii K, Kobayashi K, Nagata N, Shimizu H, Koike S, Sato H.: Cisallosteric regulation of the interaction sufaces of enterovirus A71 capsid protein by the VP1 singleamino acid residue at position 145. The 20 th Meeting of the European Study Group on the Molecular
Biology of Picornaviruses (EUROPIC 2018) (2016.6. 6, Egmond an Zee, Netherlands)

4.

Kobayashi K, Son Thanh Chu, Takashino A, Aoki Y, Matoba Y, Mizuta K, Nishimura H, Ichimura
H, Koike S. Tissue culture adaptation of enterovirus 71 selects mutant viruses that bind to HS and－ 46 －

are attenuated in vivo. The 66th Annual Meeting of The Japanese Society for Virology (2018.10.29
Kyoto, Kyoto)
5.

Kotani O, Yokoyama M, Kobayashi K, Nagata N, Shimizu H, Koike S, Sato H.: Cis-allosteric
regulation of the interaction sufaces of enterovirus A71 capsid protein by the VP1 single amino acidresidue at position 145. The 66th Annual Meeting of The Japanese Society for Virology (2018.10.29
Kyoto, Kyoto)

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

ᑠụᬛ㸸ᮾ໭኱Ꮫ⸆Ꮫ㒊㠀ᖖ໅ㅮᖌࠊᮾி኱Ꮫ㎰Ꮫ㒊㠀ᖖ໅ㅮᖌࠊ㔠ἑ኱Ꮫ་Ꮫ㒊㠀ᖖ໅ㅮᖌࠊ⋊༠་኱㠀ᖖ໅ㅮᖌ－ 47 －

ࣉࣟࢪ࢙ࢡࢺྡ

ⰼ⢊⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 7 ௳㸧
1.

Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O and Nakaya A. Serum cytokine interactions
are implicated in the mechanism of action of sublingual immunotherapy for japanese cedar
pollinosis. J Nippon Med Sch 85(5): 250-258, 2018. ᰝㄞ᭷

2.

Gotoh M, Kaminuma O, Hiroi T and Okubo K. Microarray-based multivariate analysis of theeffectiveness of sublingual immunotherapy for cedar pollinosis. Allergy Asthma Immunol Res.
10(5): 562-569, 2018. ᰝㄞ᭷

3.

Nishimura T, Kaminuma O, Saeki M, Kitamura N, Gotoh M, Mori A and Hiroi T. Effects of antiallergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.
Allergol Int. 67S:S25-S31, 2018. ᰝㄞ᭷

4.

Gotoh M, Kaminuma O, Nakaya A, Katayama K, Watanabe N, Saeki M, Nishimura T, Kitamura N,
Okubo K and Hiroi T. Involvement of taste receptors in the effectiveness of sublingual
immunotherapy. Allergol Int. 67(3): 421-424, 2018. ᰝㄞ᭷

5.

Kaminuma O, Nishimura T, Kitamura N, Saeki M, Hiroi T and Mori A. T-helper type 2 cells direct
antigen-induced eosinophilic skin inflammation in mice. Allergy Asthma Immunol Res, 10(1): 7782, 2018. ᰝㄞ᭷

6.

Kaminuma O, Katoh S, Miyagi T, Watanabe N, Kitamura N, Nishimura T, Saeki M, Mori A andHiroi T. Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells. Genes
Cells. 23(2):112-116, 2018. ᰝㄞ᭷

7.

Kaminuma O, Kitamura N, Nishito Y, Nemoto S, Tatsumi H, Mori A and Hiroi T. Downregulationof NFAT3 due to lack of T-box transcription factor TBX5 is crucial for cytokine expression in T
cells. J Immunol. 200(1): 92-100, 2018. ᰝㄞ᭷ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1.

⚄἟ ಟࠊすᮧ཭ᯞࠊᘅ஭㝯ぶ. ≉㞟 Ⰽࠎ࡞࢔ࣞࣝࢠ࣮⑌ᝈ࡟࠾ࡅࡿ᭱㏆ࡢ㐍Ṍ I㸬ෆ⛉㸬2㸬Th ⣽⬊ศ໬࡜࢔ࣞࣝࢠ࣮. ࢔ࣞࣝࢠ࣮࣭ච␿.25(2): 14-22, 2018.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

బ఑┿ᘪࠊすᮧ཭ᯞࠊ໭ᮧ⣖Ꮚࠊ᳃ ᬗኵࠊ⚄἟ ಟࠊᘅ஭㝯ぶ. Th9 ⣽⬊࡜࢔ࣞࣝࢠ࣮ᛶ⑌
ᝈ. ➨ 46 ᅇ᪥ᮏ⮫ᗋච␿Ꮫ఍⥲఍. ࣮࣋ࢩࢵࢡࢩ࣏ࣥࢪ࣒࢘ 2ࠕ᪂つ T ⣽⬊ࢧࣈࢭࢵࢺ࡜
⑌ᝈࠖ. 2018.11.8㹼11.9. 㛗㔝┴㍍஭ἑ

－ 48 －

ࡑࡢ௚ 㸦ィ 11 ௳㸧⮬⏤ᥖ㍕
1.

బ఑┿ᘪࠊᚋ⸨✨ࠊ኱ஂಖබ⿱ࠊ୰㇂᫂ᘯࠊ໭ᮧ⣖Ꮚࠊすᮧ཭ᯞࠊ⚄἟ಟࠊᘅ஭㝯ぶ⯉ୗච␿⒪ἲ࡟࠾ࡅࡿ࿡ぬཷᐜయࢆ௓ࡋࡓዌຌ࣓࢝ࢽࢬ࣒. ➨ 1 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍㛵ᮾ
ᆅ᪉఍. 2019.3.16. ᮾி㒔

2.

໭ᮧ⣖Ꮚࠊᚋ⸨ ✨ࠊ‫⏣‮‬ཌྖࠊబ఑┿ᘪࠊ⚄἟ ಟࠊᘅ஭㝯ぶ. ⰼ⢊⑕⯉ୗච␿⒪ἲࡢຠᯝⓎ⌧ᶵᗎࡢ᥈⣴. ➨ 1 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍㛵ᮾᆅ᪉఍. 2019. 3.16. ᮾி㒔3.

ᘅ஭㝯ぶࠊబ఑┿ᘪࠊすᮧ཭ᯞࠊΏ㑔ఙᫀࠊ໭ᮧ⣖Ꮚࠊᚋ⸨ ✨ࠊᑠ⏫ኴ㑻ࠊᮧୖு௓ࠊ኱
ஂಖබ⿱. ࢫࢠⰼ⢊⑕⯉ୗච␿⒪ἲࡢಶู໬་⒪ࢆ┠ᣦࡋࡓᇶ♏◊✲. ➨ 14 ᅇᮾி㒔⚟♴ಖ㝤་Ꮫ఍. 2018.12.13. ᮾி㒔4.

᳃Ọ┿ᐇᏊࠊ㊊❧(୰ᔱ)ࡣࡿࡼࠊඵᮧᩄᚿࠊᖹฟᜨ฼⳹ࠊᅵ஭㞞ὠᏊࠊ໭ᮧ⣖Ꮚࠊ⚄἟ ಟࠊᘅ஭㝯ぶ. 㣗≀࢔ࣞࣝࢠ࣮ࡢ⤒⓶ච␿⒪ἲࣔࢹࣝ࡟࠾ࡅࡿᒁᡤᛂ⟅ࡢ㔜せᛶ. ➨ 14 ᅇ᪥ᮏ㣗ရච␿Ꮫ఍. 2018.11.16. ᮾி㒔

5.

Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A and Hiroi T. Differential Property of
Murine Airway Eosinophilic Inflammation Induced by Th2 and Th9 Cells. The XXIV World
Congress of Asthma. 2018.10.3-10.6. (Tokyo)

6.

⚄἟ ಟࠊ໭ᮧ⣖ᏊࠊᐑṊ୍ᫀ㑻ࠊ᳃ ᬗኵࠊᘅ஭㝯ぶ. ㌿෗ᅉᏊ NFAT ࣇ࢓࣑࣮ࣜࡢᶵ⬟ⓗከᵝᛶ. ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍. 2018.9.25. ி㒔ᗓ7.

8.

బ఑┿ᘪࠊすᮧ཭ᯞࠊ⚄἟ ಟࠊ㧗ᮌⱥ඾ࠊ᳃ ᬗኵࠊ㧗ᒾᩥ㞝ࠊᘅ஭㝯ぶ. ࢲࢽᢠཎ⡿࡟ࡼࡿ࢔ࣞࣝࢠ࣮ᛶ⅖⑕ᢚไ࣓࢝ࢽࢬ࣒ࡢ Th2 ⣽⬊⛣ධࣔࢹࣝࢆ⏝࠸ࡓゎᯒ. ➨ 32 ᅇ࢔ࣞࣝࢠ࣮࣭ዲ㓟⌫◊✲఍. 2018.9.22. ᮾி㒔⚄἟ ಟࠊᚋ⸨ ✨ࠊ኱ஂಖබ⿱ࠊ୰㇂᫂ᘯࠊ᳃ ᬗኵࠊ໭ᮧ⣖Ꮚࠊすᮧ཭ᯞࠊబ఑┿ᘪࠊᘅ஭㝯ぶ. ⴭຠ/ ↓ຠᝈ⪅㛫ࡢẚ㍑࡟ᇶ࡙ࡃ࢔ࣞࣝࢤࣥච␿⒪ἲ࡟࠾ࡅࡿຠᯝⓎ⌧ᶵᵓࡢゎ
ᯒ. ➨ 32 ᅇ࢔ࣞࣝࢠ࣮࣭ዲ㓟⌫◊✲఍. 2018.9.22. ᮾி㒔9.

బ఑┿ᘪࠊすᮧ཭ᯞࠊ໭ᮧ⣖Ꮚࠊ᳃ ᬗኵࠊ⚄἟ ಟࠊᘅ஭㝯ぶ. Th9 ⣽⬊ࡢẼ㐨Ẽ㐨⤌⧊ᾐ₶࡟ᑐࡍࡿዲ㓟⌫ࡢᙺ๭. ➨ 67 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍Ꮫ⾡኱఍. 2018.6.22-6.24. ༓ⴥ┴

10. すᮧ཭ᯞࠊᯘၨኴ㑻ࠊబ఑┿ᘪࠊ໭ᮧ⣖Ꮚࠊ᳃ ᬗኵࠊᘅ஭㝯ぶࠊ⚄἟ ಟ. Th2 ౫Ꮡᛶ⓶⭵⅖ࣔࢹࣝ࡟ᑐࡍࡿ࢔࣑ࣀ㓟ࢺࣛࣥࢫ࣏࣮ࢱ࣮㜼ᐖ๣ࡢຠᯝ. ➨ 67 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍
Ꮫ⾡኱఍. 2018.6.22-6.24. ༓ⴥ┴
11. ᳃Ọ┿ᐇᏊࠊᖹฟᜨ฼⳹ࠊᅵ஭㞞ὠ௦ࠊ໭ᮧ⣖Ꮚࠊ⚄἟ ಟࠊᘅ஭㝯ぶࠊ㊊❧㸦୰ᔱ㸧ࡣࡿࡼࠊඵᮧᩄᚿ. 㣗≀࢔ࣞࣝࢠ࣮ࡢ⤒⓶ච␿⒪ἲࣔࢹࣝ࡟࠾ࡅࡿ T ⣽⬊ࡢ㛵୚. ➨ 67 ᅇ᪥ᮏ࢔ࣞࣝࢠ࣮Ꮫ఍Ꮫ⾡኱఍.

2018.6.22-6.24. ༓ⴥ┴

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

－ 49 －

IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

ᘅ஭㝯ぶ᪩✄⏣኱Ꮫᩍ⫱Ꮫ㒊⏕≀Ꮫ⛉࣭㠀ᖖ໅ㅮᖌ㸦2006 ᖺ㹼⌧ᅾ㸧

2.

ᘅ஭㝯ぶ᪥ᮏ኱ᏛᯇᡞṑᏛ㒊࣭㠀ᖖ໅ㅮᖌ㸦1993 ᖺ㹼⌧ᅾ㸧

3.

బ఑┿ᘪ⌮໬Ꮫ◊✲ᡤࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮࣭ᐈဨ◊✲ဨ㸦2013 ᖺ㹼⌧ᅾ㸧

4.

すᮧ཭ᯞᮾி⸆⛉኱Ꮫ࣭㠀ᖖ໅ㅮᖌ㸦2016 ᖺ㹼⌧ᅾ㸧࠙⏘ᴗ㈈⏘ᶒࠚ
1.

ྡ⛠ῶឤస⒪ἲ࡟࠾ࡅࡿ἞⒪ຠᯝࢆண ࡍࡿࣂ࢖࣐࣮࣮࢜࢝ ฟ㢪⪅㸸ᘅ஭㝯ぶࠊฟ㢪᪥ 2010.10.25 ฟ㢪␒ྕ㸸108525084.6, 10825084.6, 10, 13/498267, 2011-537332 㸦4 ௳㸧⤊஢᪥㸸2030.10.252.

ྡ⛠㸸⯉ୗឤస⒪ἲ࡟࠾ࡅࡿ἞⒪ຠᯝࢆணࡍࡿࣂ࢖࣐࣮࣮࢜࢝ 2018.4.19 ⡿ Science

Exchange ♫ࡢ࣐࢘ࢫᖺ㛫౑⏝ᩱ MTA ᖺ㛫౑⏝ᩱ 2,222 ༓෇ Ⓨ᫂⪅ᘅ஭㝯ぶ

－ 50 －

ࣉࣟࢪ࢙ࢡࢺྡ

ศᏊ་⒪ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Sadato D, Ono T, Gotoh-Saito S, Kajiwara N, Nomura N, Ukaji M, Yang L, Sakimura K, Tajima Y,
Oboki K, *Shibasaki F.: Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential forembryonic development and cell proliferation. FEBS Open Bio. 8(8):1188-1201, 2018.㸦ᰝㄞ᭷㸧
doi: 10.1002/2211-5463.12482.

2.

Li Q, Yao B, Endler A, Chen L, Shibasaki F, *Cheng H.: Int6/eIF3e Silencing Promotes Placenta
Angiogenesis in a Rat Model of Pre-eclampsia. Sci Rep. 12;8(1):8944, 2018. 㸦ᰝㄞ᭷㸧doi:
10.1038/s41598-018-27296-2.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

Ⱚᓮኴࠊᑠᯘ⾜἞ࠊ᭶ᮧ⪃ᏹࠊඡᕝᛅ㟹ࠊḈᗞᆒ㸸㓝⣲⿵඘⒪ἲࢆཷࡅࡓࣇ࢓ࣈ࣮ࣜ⑓ᝈ
⪅࡟࠾ࡅࡿᢠ GLA ᢠయ᳨ฟ⏝⡆᫆࢖࣒ࣀࢡ࣐ࣟࢺࡢ㛤Ⓨ ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘
2018ࠕ㑇ఏᛶ㞴⑓ඞ᭹࡟ྥࡅࡓ Cooperationࠖ2018. 12.14 ᮾி

2.

Ⱚᓮኴ㸸ᮍ᮶ࡢ་⒪ Precision࣭AI/RoboticS (PAIRS) Medicine ࡢ♫఍ᐇ⿦࡬ࡢࢳࣕࣞࣥࢪ
㤳㒔኱ serBOTinQ ࢭ࣑ࢼ࣮ 2018. 12.7 ᮾி㒔ࡑࡢ௚ 㸦ィ 10 ௳㸧⮬⏤ᥖ㍕
1.

ධỤᩔ㸸࢝ࢳ࢜ࣥᛶேᕤ࢜ࣜࢦ⢾࡜ಟ㣭ᆺ᰾㓟ࡢ⤌ࡳྜࢃࡏ࡟ࡼࡿ siRNA ࡢᏳᐃ໬ ᪥ᮏ⸆Ꮫ఍➨ 139 ᖺ఍ 2019.3.20㹼3.23 ༓ⴥ┴༓ⴥᕷ

2.

Ლཎ┤ᶞࠊᒣᮏ┤ᶞࠊᑠཎ㐨ἲࠊᏳ஭ᩥᙪࠊ㏕⏣⩏༤ࠊ႐⏣ᏹࠊⰪᓮኴ㸸H5N1 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢࢩ࢔ࣝ㓟㠀౫Ꮡⓗ࡞⣽⬊౵ධ⤒㊰ࡢゎᯒࠊ➨ 41 ᅇ᪥ᮏศᏊ
⏕≀Ꮫ఍ 2018.11.30 ⚄ዉᕝ┴ᶓ὾ᕷ㸦࣏ࢫࢱ࣮㸧3.

⏣ᓥ㝧୍ࠊⰪᓮኴ㸸࣐࢘ࢫ⏕యෆ࡛ࡢࡀࢇ⣽⬊࡜㛫ⴥ⣔ᖿ⣽⬊࡜ࡢ⮬↛⼥ྜࡢ᳨ウ. ➨ 41ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.29

4.

⚄ዉᕝ┴ᶓ὾ᕷ

⏣ᓥ㝧୍ࠊⰪᓮኴ㸸㛫ⴥ⣔ᖿ⣽⬊࡜ࡢ⣽⬊⼥ྜ࡟ࡼࡾస〇ࡋࡓఇ╀ࡀࢇ⣽⬊ࡢఇ╀࡟㛵㐃ࡍࡿ㑇ఏᏊࡢ᥈⣴. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.29 ⚄ዉᕝ┴ᶓ὾ᕷ

5.

⏣ᓥ㝧୍ࠊⰪᓮኴ㸸㛫ⴥ⣔ᖿ⣽⬊࡜ࡀࢇ⣽⬊࡜ࡢ in vitro ࠾ࡼࡧ in vivo ࡛ࡢ⣽⬊⼥ྜࡢ᳨
ウ. CBSM2018, 2018.10.6 ⚄ዉᕝ┴㙊಴ᕷ

－ 51 －

6.

Ⱚᓮኴ㸸➨ᅄḟ⏘ᴗ㠉࿨ࡀࡶࡓࡽࡍᮍ᮶ࡢ་⒪ Precision-AI/Robotics (PAIRS) Medicine ࡢ♫఍ᐇ⿦࡬ࡢࢳࣕࣞࣥࢪ Conference for BioSignal and Medicine (CBSM) 2018 2018.10.5 ⚄ዉᕝ┴㙊಴ᕷ

7.

Ლཎ┤ᶞࠊᒣᮏ┤ᶞࠊᑠཎ㐨ἲࠊᏳ஭ᩥᙪࠊ㏕⏣⩏༤ࠊ႐⏣ᏹࠊⰪᓮኴ㸸H5N1 㧗⑓ཎᛶ㫽࢖ࣥࣇ࢚ࣝࣥࢨ࢘࢖ࣝࢫࡢࢩ࢔ࣝ㓟㠀౫Ꮡⓗ࡞⣽⬊౵ධᶵᵓࠊConference for Bio Signal
and Medicine (CBSM) 2018, 2018.10.5 ⚄ዉᕝ┴㙊಴ᕷ㸦࣏ࢫࢱ࣮㸧

8.

Shibasaki, F.: New Therapeutic Targets of HIF2a in the Regulation of Physiological and PathologicalHypoxia-induced Angiogenesis. BK21 Plus Adjunctive Professor Lecture 2018,2018.9.6,

Korea.
9.

Shibasaki, F.: New Therapeutic Targets of HIF2a in the Regulation of Physiological and PathologicalHypoxia-induced Angiogenesis. TRANSMED-VN Conference 2018, 2018.8.19㹼8.20 Vietnam.

10. Amagai, Y., Shibasaki, F, Matsuda, H, Tanaka, A: Mast cells express vascular endothelial growth
factor in the affected skin of atopic NC/Tnd mice. European Academy of Allergy and Clinical
Immunology (EAACI), 2018.5. 26㹼5. 30, Munich,Germany.
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1.

Ⱚᓮኴ ᮍ᮶ࡢ་⒪ Precision-AI / RoboticS (PAIRS) Medicine ࡢ♫఍ᐇ⿦࡬ࡢࢳࣕࣞࣥࢪ
᪩✄⏣኱Ꮫࢼࣀࢸࢡࣀࣟࢪ࣮ࣇ࢛࣮࣒ࣛ➨ 6 ᅇศ⛉఍࣮࣡ࢡࢩࣙࢵࣉ ೺ᗣ࣭་⒪ศ㔝ࠕࡇࡇࢁࡢ࠿ࡽࡔࡢ೺ᗣ࡜་⒪ࠖ 2019.3.13 ᪩✄⏣኱Ꮫ┴⣭㛤Ⓨࢭࣥࢱ࣮ ᮾி㒔᪂ᐟ༊

IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

Ⱚᓮኴ㸸㡑ᅜᘏୡ኱Ꮫ࣭ᐈဨᩍᤵ㸦2014 ᖺ㹼㸧ࠊග⏘ᴗ๰ᡂ኱Ꮫ㝔኱Ꮫ࣭ᐈဨᩍᤵ㸦2015ᖺ㹼㸧ࠊཬࡧ୕㔜኱Ꮫࡢ≉ูㅮ⩏࠙ࡑࡢ௚ࠚ
1.

Ⱚᓮኴ㸸➨ 18 ᅇ Conference of BioSignal and Medicine (CBSM)኱఍㛗ࠊTOBIRA ๪⌮஦㸦2016ᖺᗘ㹼㸧－ 52 －

ࣉࣟࢪ࢙ࢡࢺྡ

ㄆ▱⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 13 ௳㸧
1.

Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado, H., Hasegawa M.
C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated
TDP-43. Hum Mol Genet, 2018 May 10. doi: 10.1093/hmg/ddy174.

2.

Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M. The effect of truncation
on prion-like properties of Į -synuclein. J Biol Chem 293:13910-13920, 2018. doi:
10.1074/jbc.RA118.001862.

3.

Franco R, Andrésn DA, Canela EI, Lillo J, Tarutani A, Hasegawa M, Del Rio JA, Kreutz MR, Saura
C,Navarro D. N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical andhippocampal neurons and microglia is dependent on calcium sensors and is blocked by Į-synuclein,
Tau and phospho-Tau in non-transgenic and transgenic APPSw, Ind mice. Front Mol Neurosci. 2018
Aug 28;11:273. doi: 10.3389/fnmol.2018.00273.

4.

Hasegawa I, Takeda A, Hatsuta H, Kubo Y, Ohsawa M, Nakano Y, Ikeuchi T, Hasegawa M,
Murayama S, Itoh Y. An autopsy case of globular glial tauopathy presenting with clinical features ofmotor neuron disease with dementia and iron deposition in the motor cortex. Neuropathology inpress.

5.

Watanabe R, Kawakami I, Onaya M, Higashi S, Arai N, Akiyama H, Hasegawa M, Arai T.
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting withcatatonic syndrome. Neuropathology 38(3): 281-287, 2018.

6.

Uchino A, Ogino M, Takahashi-Fujigasaki J, Oonuma S, Kanazawa N, Kajita S, Ichinoe M,
Hasegawa M, Nishiyama K, Murayama S. Pathological and immunoblot analysis of phosphorylated
TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration.
Neuropathology 38(2): 171-178, 2018.

7.

Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI.
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau inmouse brain during postnatal development. J Biol Chem 293(5): 1781-1793, 2018.

8.

Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa
M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R.
Pathological  Endogenous Ș -Synuclein
Cells

AccumulationinOligodendrocyte

Precursor

Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Rep. 10(2): 356-365,

2018.
9.

Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M,
Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y,
Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki
H. Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-－ 53 －

like syndrome. Sci Rep 8(1): 819, 2018.
10. Tarutani, A, Arai T Murayama, S., Hisanaga, S.I., Hasegawa, M. Potent prion-like behaviors of
pathogenic Į-synuclein and evaluation of inactivation methods. Acta Neuropathol Commun 6: 29,
2018.
11. Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S,
Shiraishi T, Murayama S. Unusual tau pathology of the cerebellum in patients with amyotrophic
lateral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. Brain Pathol 28:287-291, 2018.
12. Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M. Progranulin haploinsufficiency
reduces amyloid beta deposition in Alzheimer's disease model mice. Exp Anim 67: 63-70, 2018.
13. Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar J, Vila M, Samitier J,
Torrents E, Ferrer I, Gavín R, Hasegawa M, José Antonio del Río. Involvement of Cellular Prion
Protein inĮ-Synuclein Transport in Neurons. Mol Neurobiol 55: 1861, 2018.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

Kametani F and Hasegawa M. Reconsideration of Amyloid Hypothesis and Tau Hypothesis in
Alzheimer's Disease. Front Neurosci 12: 25, 2018.

2.

Nonaka T, Masuda-Suzukake M, Hasegawa M. Molecular mechanisms of the co-deposition ofmultiple pathological proteins in neurodegenerative diseases. Neuropathology. 38(1): 64-71, 2018.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 13 ௳㸧
1.

Hasegawa M Prion-like propagation of pathological tau in neurodegenerative diseases. Japan-UK
Neuroscience Symposium, 2019.2.10, Chiba.

 㛗㇂ᕝᡂே ࣐࣮ࣔࢭࢵࢺ⬻࡟࠾ࡅࡿ␗ᖖȘࢩࢾࢡࣞ࢖ࣥ⑓ኚࡢᙧᡂ࡜ఏ᧛ ᪥ᮏ࣐࣮ࣔࢭࢵࢺ◊✲఍኱఍2019. 2. 7,ᮾி㒔
3.

㛗㇂ᕝᡂே Į ࢩࢾࢡࣞ࢖ࣥࡢఏ᧛. ➨ 36 ᅇ ⚄⤒἞⒪Ꮫ఍Ꮫ⾡㞟఍ ࢩ࣏ࣥࢪ࣒࢘ Įࢩࢾࢡࣞ࢖ࣀࣃࢳ࣮ࡢ⮫ᗋ࡜ᇶ♏-1, 2018.11.25, ᮾி㒔4.

㛗㇂ᕝᡂே Į ࢩࢾࢡࣞ࢖ࣥࡢఏ᧛ᶵᵓ. ➨ 20 ᅇ໭㝣ㄆࣉࣟ FD ㅮ₇఍, 2018.11.6, ▼ᕝ┴

5.

㛗㇂ᕝᡂே ␗ᖖ⺮ⓑ㉁ఏ᧛࡛⪃࠼ࡿ࢔ࣝࢶࣁ࢖࣐࣮⑓ࠊࣃ࣮࢟ࣥࢯࣥ⑓ࠊALS. ➨ 23ᅇ᪥ᮏ⚄⤒ឤᰁ⑕Ꮫ఍⥲఍࣭Ꮫ⾡኱఍ ᩍ⫱ㅮ₇, 2018.10.19, ᮾி㒔

6.

㛗㇂ᕝᡂே ㄆ▱⑕⑌ᝈ࡟࠾ࡅࡿࢱ࢘ࡢ␗ᖖ࡜ఏ᧛. ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ ࢩ࣏ࣥࢪ࣒࢘㺀⬻ࢱࣥࣃࢡ㉁⪁໬࡜⚄⤒ኚᛶ㺁 2018. 9.25, ி㒔ᗓ

7.

Hasegawa M Prion-like propagation of pathological tau in neurodegenerative diseases. ICN2018
Symposium 12, Protein Propagation in Neurodegeneration, 2018.9.24, Tokyo8.

㛗㇂ᕝᡂே ␗ᖖᆺࢱ࢘ࡢఏ᧛࡛⪃࠼ࡿ࢔ࣝࢶࣁ࢖࣐࣮⑓, ༓㔛ࣛ࢖ࣇࢧ࢖࢚ࣥࢫࢭ࣑
ࢼ࣮, 2018.9.19 ኱㜰ᗓ9.

㛗㇂ᕝᡂே ࢱ࢘⑓ኚࡢఏ᧛ࢆ෌⌧ࡍࡿ࣐࢘ࢫࣔࢹࣝ. ➨ 6 ᅇ᪥ᮏ࢔࣑ࣟ࢖ࢻ࣮ࢩࢫ◊✲－ 54 －

఍.

2018.8.24 㛗㔝┴ᯇᮏᕷ

10. Hasegawa M Į-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy. Basic
Science Summer School MDS/Education/Conferences & Courses, 2018.8.3, Osaka
11. 㛗㇂ᕝᡂே ⚄⤒ኚᛶ⑌ᝈ࡟࠾ࡅࡿ⣽⬊ෆ␗ᖖࢱࣥࣃࢡ㉁ࡢࣉࣜ࢜ࣥᵝఏ᧛. ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ఍ ᩍ⫱ㅮ₇, 2018.7.27, රᗜ┴
12. Hasegawa M ĮSynuclein in Parkinson’s disease and related disorders. WCP2018 KYOTO (18thWorld Congress of Basic and Clinical Pharmacology), 2018.7.5, Kyoto
13. Hasegawa M Tau aggregation mechanisms and therapeutic strategies for AD. ➨59ᅇ᪥ᮏ⚄⤒Ꮫ఍⥲఍ Alzheimer’s disease up to date. 2018. 5. 25. ໭ᾏ㐨.
ࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧
1.

⣽ᕝ㞞ே ࢱ࢘ఏ᧛ࣔࢹ࣐ࣝ࢘ࢫࡢస〇 ➨ 92 ᅇ᪥ᮏ⸆⌮Ꮫ఍ 2019.3.13㹼3.16 ኱㜰ᅜ㝿఍㆟ሙ ኱㜰ᗓ2.

⣽ᕝ㞞ே Progranulin Haploinsufficiency reduces amyloid beta deposition in alzheimer's disease
mouse model,

11th International Conference on Frontotemporal Dementias 2018.11.10㹼11.14

Sydney,Australia
3.

⣽ᕝ㞞ே GRN ኚ␗⬻࡟࠾ࡅࡿ⚄⤒ኚᛶ⑌ᝈ㛵㐃ࢱࣥࣃࢡࡢ㔜」⵳✚࡜࣑ࢡࣟࢢࣜ࢔
➨ 3 ᅇࣉࣟࢢࣛࢽࣗࣜࣥ◊✲఍ 2018.6.9 ᒱ㜧┴4.

⣽ᕝ㞞ே 㧊ᾮ᳨ᰝࡢ᭷⏝ᛶ ➨ 59 ᅇ᪥ᮏ⚄⤒Ꮫ఍ 2018.5.23㹼5.26 ໭ᾏ㐨IV. ≉グ஦㡯－ 55 －

ࣉࣟࢪ࢙ࢡࢺྡ

Ꮫ⩦グ᠈ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

Matsuno M, Horiuchi J, Ofusa K, Masuda T, Saitoe M. (2019). Inhibiting glutamate activity duringconsolidation suppresses age-related long-term memory impairment in Drosophila. iScience 15, 5565.

2.

Ueno K, Morstein J, Ofusa K, Naganos S, Suzuki-Sawano E, Minegishi A, Kitagishi H, Chang C,
Horiuchi J, Saitoe M (2018). Carbon monoxide, a retrograde messenger generated in post-synaptic
mushroom body neurons evokes local dopamine release. bioRxiv.
doi: https://doi.org/10.1101/382127

3.

Miyashita T, Kikuchi E, Horiuchi J, Saitoe M. Long-term memory engram cells are established byc-Fos/CREB transcriptional cycling. Cell Rep in press.

4.

Sato S, Ueno K, Saitoe M, Sakai T. (2018). Synaptic depression induced by postsynaptic cAMP
production in the Drosophila mushroom body calyx. J Physiol. 2018 Apr 16.
doi: 10.1113/JP275799. [Epub ahead of print]ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1. 㰺⸨ᐇ 㐃ྜᙉ໬ࢩࢢࢼࣝ࡜ࡋ࡚ࡢ᪂つࢻ࣮ࣃ࣑ࣥᨺฟᶵᵓ ➨ 35 ᅇ㧗ᓠ࢝ࣥࣇ࢓ࣞࣥ
ࢫ㸦ᮾி㒔ዴỈ఍㤋 2019.3.1㸧
2. Saitoe M. Retrograde Signal for Local Dopamine Release. in Model Organism, Korean Society of
Molecular and Cellular Biology 㸦COEX, Seoul 2018. 9.18㸧
ࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕
1.

ᐑୗ▱அࠊᐑᆅᏕ᫂ࠊ኱ᡣிᏊࠊ⳥ᆅ⤮⨾ࠊ᳃ᒣⰾ๎ࠊ㰺⸨ᐇ ໝ࠸᎘ᝏᏛ⩦࡟࠾ࡅࡿ㟁Ẽࢩࣙࢵࢡࡢ᝟ሗࡣࢢࣜ࢔⣽⬊࠿ࡽࡢࢢࣝࢱ࣑ࣥ㓟㛤ཱྀᨺฟ࡟ࡼࡗ࡚࢟ࣀࢥయ࡟ఏ㐩ࡉࢀࡿ ➨ 41 ᅇ᪥ᮏ⚄⤒⛉ᏛᏛ఍㸦⚄ᡞᅜ㝿఍㆟ሙ 2018.7.26㸧

2.

㛗㔝ៅኴ㑻ࠊ㰺⸨ᐇ グ᠈ᙉ໬࡜᝿㉳ࡣ␗࡞ࡿࢻ࣮ࣃ࣑ࣥ⚄⤒ࡀᢸ࠺ FSCV ἲ࡟ࡼࡿゎᯒ➨ 41 ᅇ᪥ᮏ⚄⤒⛉ᏛᏛ఍㸦⚄ᡞᅜ㝿఍㆟ሙ 2018.7.27㸧

3.

ᯇ㔝ඖ⨾ࠊୖᮧᮃࠊᇼෆ⣧஧㑻ࠊ኱ᡣிᏊࠊ㰺⸨ᐇ ຍ㱋ᛶ㛗ᮇグ᠈㞀ᐖࡣグ᠈ᅛᐃ᫬ࡢ
ࢻ࣮ࣃ࣑ࣥసືᛶ⚄⤒ࡢ㐣๫⯆ዧ࡟ࡼࡾ⏕ࡌࡿ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍㸦ࣃࢩࣇ࢕ࢥ
ᶓ὾ 2018.11.25㸧

－ 56 －

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯
1. 㰺⸨ᐇ ➨ 11 ᅇศᏊ㧗ḟᶵ⬟◊✲఍ ௻⏬㸦㫽⩚࠿ࢇࡱࡢᐟ 2018.8.22㹼8.24㸧

－ 57 －

ࣉࣟࢪ࢙ࢡࢺྡ

⬻ᶵ⬟෌ᘓࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Chao Z. C., Sawada M, Isa T, Nishimura Y. Dynamic Reorganization of Motor Networks During
Recovery from Partial Spinal Cord Injury in Monkeys. Cerebral Cortex, 2018; 1–15. doi:
10.1093/cercor/bhy172.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

㕥ᮌ㏔ㄹࠊ୰ᒣ⩏ஂࠊすᮧᖾ⏨ ⢭⚄≧ែ࡜㐠ືࣃࣇ࢛࣮࣐ࣥࢫ Clinical Neuroscience‒ ู෉ ࢫ࣏࣮ࢶ⚄⤒እയ࡜࢔ࢫ࣮ࣜࢺࡢ⬻⛉Ꮫ 36 ᕳ 10 ྕ:1216-1218.

2.

ຍ⸨೺἞ࠊすᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ᑐࡍࡿᰂ㌾࡞㐠ື㐺ᛂ ⮫ᗋ⚄⤒⏕⌮Ꮫ  ≉㞟ࠕBMI/BCI ࡢᛂ⏝࡟ྥࡅ࡚ࠖ46 ᕳ 1 ྕ:40-46 2018

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 8 ௳㸧
1.

Yukio Nishimura Bypassing damaged neural pathways via a neural interface. German-JapaneseWorkshop on New Directions in System Neuroscience. Tuebingen. 2019.3.21 ࢻ࢖ࢶ

2.

すᮧᖾ⏨ ཮᪉ྥᛶ⚄⤒άື᧯స࡛ഃᆘ᰾ࡢᙺ๭ࢆ᥈ࡿࠊ➨ 58 ᅇ᪥ᮏᐃ఩࣭ᶵ⬟⚄⤒እ⛉Ꮫ఍ࠊ㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝࠊ2019.1.26 ᮾி㒔

3.

Yukio Nishimura, Challenge to bridging the corticospinal pathways. A Symposium to Honor the
Career of Eberhard E. Fetz. Hilton San Diego Bayfront. 2018.11.1 USA

4.

すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ࡼࡿ⚄⤒ᶵ⬟෌ᘓࠊ᪥ᮏ⬻⚄⤒እ⛉Ꮫ఍ ➨ 77 ᅇ⥲఍ࠊ௝ྎᅜ
㝿ࢭࣥࢱ࣮ 2018.10.10 ᐑᇛ┴

5.

すᮧᖾ⏨ ᚰࡀ㌟యࢆື࠿ࡍ⚄⤒ᇶ┙ࠊ➨ 39 ᅇ᪥ᮏ⫧‶Ꮫ఍ྜྠࢩ࣏ࣥࢪ࣒࢘ 2 ືࡁࡢ⏕≀Ꮫࠊ⚄ᡞᅜ㝿఍㆟ሙ 2018.10.8 රᗜ┴

6.

すᮧᖾ⏨ ᚰࡀ㌟యࢆື࠿ࡍ⚄⤒ᇶ┙ࠊᖹᡂ 30 ᖺᗘ⏕⌮◊◊✲఍ ➨ 2 ᅇࣄࢺ⬻࢖࣓࣮ࢪࣥࢢ◊✲఍ࠊ⋢ᕝ኱Ꮫ 2018.9.8 ᮾி㒔7.

すᮧᖾ⏨ ⬻⬨㧊ᦆയᚋࡢᶵ⬟ᅇ᚟ᶵᗎ࡜ᶵ⬟෌ᘓἲࠊ➨ 25 ᅇ ⬻ᶵ⬟࡜ࣜࣁࣅࣜࢸ࣮ࢩ
ࣙࣥ◊✲఍ Ꮫ⾡㞟఍ࠊ༓ⴥ┴❧ಖ೺་⒪኱Ꮫᖥᙇ࢟ࣕࣥࣃࢫ 2018.08.19 ༓ⴥ┴

8.

すᮧᖾ⏨ ேᕤ⚄⤒᥋⥆࡟ࡼࡿ⬻ᶵ⬟෌ᘓࠊTOBIRA ➨ 7 ᅇ◊✲஺ὶࣇ࢛࣮࣒ࣛࠊࢯࣛࢩ
ࢸ࢕࢝ࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮ ࢯࣛࢩࢸ࢕࣮࣍ࣝࠊ2018.5.11 ᮾி㒔ࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕
1.

Yukio Nishimura Bypassing damaged neural pathways via a neural interface. FAOPS2019. ⚄ᡞᅜ㝿఍㆟ሙ. 2019.3.29 රᗜ┴－ 58 －

2.

すᮧᖾ⏨ ពḧࡀ➽ฟຊࢆ⏕ᡂࡍࡿ⚄⤒ᇶ┙ࡢゎ᫂ࠊᖹᡂ 30 ᖺᗘ ி㒔኱Ꮫ㟋㛗㢮◊✲ᡤඹྠ฼⏝◊✲఍ࠕඛ➃ᢏ⾡ࡢᑟධ࡟ࡼࡿ㟋㛗㢮⬻⛉Ꮫࡢ㐍ᒎ࡜᪂ࡓ࡞ᴫᛕࡢ๰ฟࠖࠊ㟋㛗㢮◊✲ᡤࠊ2019.3.16 ឡ▱┴

3.

すᮧᖾ⏨ ࣄࢺ⬨㧊Ṍ⾜୰ᯡࡢⓎ᣺⌧㇟ࡢไᚚࠊ᪂Ꮫ⾡㡿ᇦ◊✲ࠕ㠀⥺ᙧⓎ᣺⌧㇟ࢆᇶ┙࡜ࡋࡓࣄ࣮࣐ࣗࣥࢿ࢖ࢳ࣮ࣕࡢ⌮ゎࠖ㸦࢜ࢩࣟࣟࢪ࣮㸧⌜఍㆟ࠊࢢ࣮ࣜࣥࣆ࢔኱἟ࠊ2018.6.10
໭ᾏ㐨

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1.

すᮧᖾ⏨ ➨ 8 ᅇ㒔་Ꮫ◊ࢩ࣏ࣥࢪ࣒࢘ࠕࢫ࣏࣮ࢶ⬻⛉Ꮫࡢ๰ᡂࠖ࣋ࣝࢧ࣮ࢳ⚄ಖ⏫࢔ࢿ
ࢵࢡࢫ 2018.11.30 ᮾி㒔IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

すᮧᖾ⏨ ᪂₲኱Ꮫ㐃ᦠ኱Ꮫ㝔 ᐈဨᩍᤵ2.

▼⏣⿱᫛ ᮾி㒔❧ᯇἑ⑓㝔 ࢡࣝࢢࢫ 2018.11.27

3.

すᮧᖾ⏨ ᮾி㒔❧ᯇἑ⑓㝔 ࢡࣝࢢࢫ 2018.7.3

4.

◊✲⏕ཷࡅධࢀ ᪂₲኱Ꮫ኱Ꮫ㝔 ་Ꮫ◊✲⛉㸦3 ྡ㸧ࠊி㒔኱Ꮫ኱Ꮫ㝔 ་Ꮫ◊✲⛉㸦1 ྡ㸧ᮾி኱Ꮫ኱Ꮫ㝔 ⥲ྜᩥ໬◊✲⛉㸦1 ྡ㸧ࠊ᪩✄⏣኱Ꮫ ⌮ᕤᏛ㒊㸦1 ྡ㸧

࠙ࡑࡢ௚ࠚ
1.

すᮧᖾ⏨ FAOPS 2019 ࢫࣆ࣮ࢻࢫࢣ࣮ࢺࡢᑠᖹዉ⥴㑅ᡭ㸦ಙᕞ኱ࢫ࣏࣮ࢶ⛉Ꮫ༞㸧࡜ࡑࡢࢥ࣮ࢳࡢ⤖ᇛ໷ၨᩍᤵ㸦ಙᕞ኱㸧ࡢ Special Guest talk ࢖ࣥࢱࣅ࣮ࣗ࢔࣮

2.

すᮧᖾ⏨ࠊ⏣ῧṓᶞ ᫎ⏬ࠕே㨶ࡢ╀ࡿᐙࠖ2018.11.16 ࡼࡾୖᫎ3.

㕥ᮌ㏔ㄹ ➨ 12 ᅇ࣮ࣔࢱ࣮ࢥࣥࢺ࣮ࣟࣝ◊✲఍ࠕⱝᡭ◊✲ዡບ㈹ࠖཷ㈹ 2018.8.20－ 59 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࡇ࡝ࡶࡢ⬻ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

Igarashi A, *Sakuma H, Hayashi M, Noto D, Miyake S, Okumura A, Shimizu T. Cytokine-induced
differentiation of hematopoietic cells into microglia-like cells in vitro. Clin Exp Neuroimmunol 2018
9:139-149. doi: 10.1111/cen3.12429㸦ᰝㄞ᭷㸧

2.

Shima T, *Sakuma H, Suzuki T, Kohyama K, Matsuoka T, Hayashi M, Okumura A, Shimizu T.
Effects of antiepileptic drugs on microglial properties. Epilepsy Seizure 2018

10: 22-32. doi:

10.3805/eands.10.22㸦ᰝㄞ᭷㸧
3.

Okumura R, Yamazaki S, Ohashi T, Magara S, Tohyama J, Sakuma H, Hayashi M, Saitoh A.
Neuropsychiatric Disorder Associated with Group G Streptococcus Infection. Case Rep Pediatr.
2018:6047318. doi: 10.1155/2018/6047318. 㸦ᰝㄞ᭷㸧

4.

Takanashi JI, Yasukawa K, Murofushi Y, Masunaga A, Sakuma H, Hayashi M. Loss of myelinatedaxons and astrocytosis in an autopsy case of acute encephalopathy with biphasic seizures and late
reduced diffusion. Brain Dev. 2018;40:947-951. doi: 10.1016/j.braindev.2018.06.004.㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 1 ௳㸧
1.

బஂ㛫ၨ ⮬ᕫච␿ᛶ኱⬻ᇶᗏ᰾㞀ᐖ࡜⮬ᕫᢠయ㸬BRAIN and NERVE-⚄⤒◊✲ࡢ㐍Ṍ㸬
2018; 70: 363-369.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 7 ௳㸧1.

బ ஂ 㛫 ၨ  ᑠ ඣ ࡢ ච ␿ᛶ ⚄ ⤒ ⑌ ᝈ ࡬ ࡢ ࢔ ࣉ ࣮ࣟ ࢳ  ➨ 48 ᅇ ᑠ ඣ ⚄⤒ Ꮫ ࢭ ࣑ ࢼ ࣮
2018.11.23㹼11.25 (11.23). ኱㜰ᗓ2.

Sakuma H. Autoantibodies and Pathogenic Mechanisms in Autoimmune Epilepsy. 16th Asian andOceanian Congress of Neurology. 2018.11.8㹼11.11 (11.9)

3.

Seoul, Korea.

బஂ㛫ၨ ᛴᛶ⬻⅖࣭⬻⑕࡜࡚ࢇ࠿ࢇⓎ⏕ᶵᗎ ௻⏬ࢭࢵࢩࣙࣥࠕᛴᛶ⬻⅖࣭⬻⑕࡬ࡢᑐᛂࠖ ➨ 52 ᅇ᪥ᮏ࡚ࢇ࠿ࢇᏛ఍Ꮫ⾡㞟఍ 2018.10.25㹼10.27 (10.27) ⚄ዉᕝ┴ᶓ὾ᕷ

4.

బஂ㛫ၨࠕᑠඣᛴᛶ⬻⑕デ⒪࢞࢖ࢻࣛ࢖ࣥࠖࢆㄞࡳゎࡃ ➨ 32 ᅇ᪥ᮏᑠඣᩆᛴ་Ꮫ఍Ꮫ
⾡㞟఍ 2018.6.1㹼6.3 (6.3) Ⲉᇛ┴ࡘࡃࡤᕷ5.

బஂ㛫ၨ ⬻⑕࡜⚄⤒⅖⑕-㞴἞㢖ᅇ㒊ศⓎస㔜✚ᆺ⬻⅖ࢆ୰ᚰ࡟㸸ࢩ࣏ࣥࢪ࣒࢘ࠕᛴᛶ⬻⑕ࡢ᭱᪂▱ぢࠖ ➨ 60 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍ 2018.5.29㹼5.31 (5.31) ༓ⴥ┴ᖥᙇᕷ

6.

Sakuma H. Diagnostic laboratory testing for immune-mediated neurological disorders. The 22th Annual &Scientific Meeting of Taiwan Child Neurology Society. 2018.5.26㹼5.27 (5.26). Taipei, Taiwan

7.

Sakuma H. Pediatric demyelinating disorders associated with autoantibody to myelin－ 60 －

oligodendrocyte glycoprotein (MOG) The 22th Annual & Scientific Meeting of Taiwan Child
Neurology Society. 2018.5.26㹼5.27 (5.27). Taipei, Taiwanࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯࠙Ꮫ⾡άືࠚ
1.

బஂ㛫ၨ ⱥᩥㄅ “Brain & Development” (Elsevier): managing editor ࡜ࡋ࡚⦅㞟࡟㈉⊩2.

బஂ㛫ၨ ᪥ᮏᑠඣ⚄⤒Ꮫ఍࿴ᩥᏛ఍ㄅࠕ⬻࡜Ⓨ㐩ࠖ๪⦅㞟㛗࡜ࡋ࡚⦅㞟࡟㈉⊩3.

బஂ㛫ၨ ᪥ᮏᑠඣ⚄⤒Ꮫ఍ホ㆟ဨ

4.

బஂ㛫ၨ ᪥ᮏ⚄⤒ච␿Ꮫ఍ホ㆟ဨ

5.

బஂ㛫ၨ ᪥ᮏᑠඣච␿ᛶ⬻⅖◊✲ࢢ࣮ࣝࣉୡヰே

6.

బஂ㛫ၨ ࠕᑠඣᛴᛶ⬻⑕࢞࢖ࢻࣛ࢖ࣥࠖ⟇ᐃ࡟㛵୚

7.

బஂ㛫ၨ ᪥ᮏᑠඣ⚄⤒Ꮫ఍ᑠ៏࣭㞴⑓ጤဨ఍ጤဨ࡜ࡋ࡚ࠊ㞴἞㢖ᅇ㒊ศⓎస㔜✚ᆺᛴᛶ
⬻⅖࡜ᢠ NMDA ཷᐜయ⬻⅖ࡢᑠ៏࣭㞴⑓⑌ᝈㄆᐃࢆ୺ᑟ

－ 61 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࢩࢼࣉࢫྍረᛶࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Shimada T, Yamagata K. Pentylenetetrazole-Induced Kindling Mouse Model. JoVE. 12;(136), 2018.
㸦ᰝㄞ᭷㸧

2.

Azuchi Y, Namekata K, Shimada T, Guo X, Kimura A, Harada C, Saito A, Yamagata K, Harada
T. Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury. Sci
Rep㻚 8(1):10132, 2018.㸦ᰝㄞ᭷㸧

3.

Baba K, Yoshida W, Toriyama M, Shimada T, Manning CF, Saito M, Kohno K, Trimmer JS,
Watanabe R, Inagaki N. Gradient-reading and mechano-effector machinery for netrin-1-induced
axon guidance. Elife. 7. pii: e34593, 2018.㸦ᰝㄞ᭷㸧

4.

Suzuki H, Nishida H, Kondo H, Yoda R, Iwata T, Nakayama K, Enomoto T, Wu J, Moriya-Ito K,
Miyazaki M, Wakabayashi Y, Kishida T, Okabe M, Suzuki Y, Ito T, Hirota J, Nikaido M. A
single pheromone receptor gene conserved across 400 million years of vertebrate evolution. Mol
Biol Evol, 35:2928-2939, 2018.㸦ᰝㄞ᭷㸧

5.

Hisatsune C, Hamada K, Mikoshiba K. Ca2+ signaling and spinocerebellar ataxia. Biochim
Biophys Acta Mol Cell Res. 16. pii: S0167-4889(18)30093-4, 2018.㸦ᰝㄞ᭷㸧6.

Moriya-Ito K, Hayakawa T, Suzuki H, Hagino-Yamagishi K, Nikaido M. Evolution ofvomeronasal receptor 1 (V1R) genes in the common marmoset (Callithrix jacchus). Gene.
642:343-353, 2018.㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧
1.

ᒣᙧせேࠊᓥ⏣ᛅஅࠊᮡᾆᘯᏊ ⮬㛢⑕࡟࠾ࡅࡿࢩࢼࣉࢫ␗ᖖࡢ᪂▱ぢࠊ᭶หࠕ⣽⬊ࠖࠊ
50:731-734, 2018.

2.

Yasuda S, Sugiura H and *Yamagata K. Mek3. In: Choi S. (eds) Encyclopedia of Signaling
Molecules. Springer, Cham, 2018.㸦ᰝㄞ᭷㸧

3.

*Shimada T, Sugiura H and *Yamagata K. RHEB. In: Choi S. (eds) Encyclopedia of Signaling
Molecules. Springer, Cham, 2018.㸦ᰝㄞ᭷㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

Yamagata K, Sugiura H, Shimada T, Goto JI, Fujiwara H, Yasuda S, Kobayashi T, Hino O, Fujii S
and Worley PF. Rheb inhibitors restore cognitive deficits in a mouse model of tuberous sclerosis
complex. International Tuberous Sclerosis Complex Research Conference 2018 (2018.9.14)2.

ᒣᙧせேࠊᓥ⏣ᛅஅࠊᮡᾆᘯᏊ ⤖⠇ᛶ◳໬⑕࡟ᑐࡍࡿ᪂ࡋ࠸἞⒪⸆ࡢ᥈⣴ ➨ 30 ᅇ࡚ࢇ࠿ࢇ἞⒪◊✲᣺⯆㈈ᅋ◊✲ሗ࿌఍㸦2019-3-1 ྿⏣㸧－ 62 －

ࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

ᏲᒇᩗᏊࠊᓥ⏣ᛅஅࠊᮡᾆᘯᏊࠊᒣᙧせே ⤖⠇ᛶ◳໬⑕ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿグ᠈㞀ᐖ࡜ṑ≧ᅇ㢛⢏⣽⬊ࡢάື␗ᖖ ➨ 27 ᅇᾏ㤿࡜㧗ḟ⬻ᶵ⬟Ꮫ఍ 2018.9.29 ᮾி㒔

2.

Shimada T, Sugiura H, Yamagata K. Mechanism of memory impairment in astrocyte specific Tsc1
knockout mouse. 61st Annual Meeting of the Japanese Society for Neurochemistry. 2018.9.8
Kobe.

3.

Takemiya T, Kawakami M, Yamagata K, Yasuda S, Izumi K. A new model of attentiondeficit/hyperactivity disorder (ADHD) related with Arcadlin. 61st Annual Meeting of the JapaneseSociety for Neurochemistry. 2018.9.8 Kobe.

4.

Shimada T, Sugiura H, Yamagata K. Memory impairment in astrocyte-specific Tsc1 knockout mice
was recovered by Rheb inhibition. 22nd Biennial Meeting of the International Society for
Developmental Neuroscience. 2018.5.22 Nara

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1㸬 ᒣᙧせேࠊዟᮧᙲஂ ⤖⠇ᛶ◳໬⑕ࡢ▱ⓗ㞀ᐖ࣭⮬㛢⑕࡟ᑐࡍࡿ᪂ࡋ࠸἞⒪⸆ࡢ᥈⣴
AMED 2018 ᖺᗘ 6 ஦ᴗ⾜ືᡂᯝሗ࿌఍ (2019-2-8 ᮾி)
IV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

ᒣᙧせே ῄᚨ኱Ꮫᐈဨᩍᤵ㸦2008 ᖺ㹼㸧

2.

ᒣᙧせே ᪂₲኱Ꮫ་Ꮫ㒊㠀ᖖ໅ㅮᖌ㸦2013 ᖺ㹼㸧࠙Ꮫ⾡άືࠚ
1.

ᒣᙧせே Scientific Reports (Nature Publishing Group) ࡞࡝ࡢ Editorial Board Member࠙≉チ࣭ࣛ࢖ࢭࣥࢫάືࠚ
1.

ᒣᙧせேࠊᓥ⏣ᛅஅࠊᮡᾆᘯᏊࠊᏳ⏣᪂ࠕ▱ⓗ㞀ᐖཪࡣ⮬㛢⑕἞⒪⸆ࠖ
㸦2018.11.7 PCT ฟ
㢪/JP2018/041393㸧

࠙᪂⪺ሗ㐨ࠚ
1. ࠕ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ⑕἞⒪⸆ࢆඹྠ㛤Ⓨࠖ㸦໬Ꮫᕤᴗ᪥ሗ 2019 ᖺ 2 ᭶ 1 ᪥㸧
㸦ඹྠ◊✲
⪅࡜ࡋ࡚㸧

－ 63 －

ࣉࣟࢪ࢙ࢡࢺྡ

⚄⤒⣽⬊ศ໬ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 9 ௳㸧1.

Yamasaki S, Ando S, Richards M, Hatch SL, Koike S, Fujikawa S, Kanata S, Endo K, Morimoto Y,
Arai M, Okado H, Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K, Nishida A. Maternal
diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old
offspring: A population-based birth cohort study. Schizophr Res. in press.

2.

Kita M, Nakae J, Kawano Y, Asahara H, Takemori H, Okado H, Itoh H. (2019) Zfp238 regulates thethermogenic program in cooperation with Foxo1. iScience. 12:87-101.

3.

Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado H, Hasegawa M.
(2018) C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation ofphosphorylated TDP-43. Hum Mol Genet. 27:2658–2670.

4.

Ken-ichi Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M.
(2019) Recruitment of calbindin into nigral dopamine neurons protects against drug-induced
parkinsonism. Movement Disorders 34(2):200-209.

5.

Toda H, Kawasaki K, Sato S, Horie M, Nakahara K, Bepari AK, Sawahata H, Suzuki T, Okado H,
Takebayashi H, Hasegawa I. Locally induced neuronal synchrony precisely propagates to specificcortical areas without rhythm distortion. Sci Rep. 8:7678

6.

Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado H, Hasegawa M.
C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated
TDP-43. Hum Mol Genet. in press 20187.

Ohtaka-Maruyama C, Okamoto M, Endo K, Oshima M, Kaneko N, Yura K, Okado H, Miyata T,
Maeda N. Synaptic transmission from subplate neurons controls radial migration of neocorticalneurons. Science. 360:313-317 20188.

Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y, McClung CA.
Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the Clockǻ Model ofBipolar Mania. Biol Psychiatry. 84:817-826 20189.

Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A,
Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G. Silencing of FUS in the common
marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding
shRNA. Neurosci Res. 130:56-64 2018ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

Hirai S, Hotta K, Okado H. (2018) Developmental roles and evolutionary significance of AMPAtype glutamate receptors. BioEssays. 40:e1800028.

2.

Okado H. (2019) Regulation of brain development and brain function by the transcriptional repressor
RP58. Brain Res. 1705:15-23.

－ 64 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

⏣୰ᬛᏊ ຍ㱋ᛶᶵ⬟㞀ᐖࡢศᏊᶵᵓࡢゎ᫂ ⸆≀࣭⢭⚄࣭⾜ືࡢ఍ࢭ࣑ࢼ࣮ 2018.8.24.
ᮾி2.

ᒸᡞᬕ⏕ ኱⬻⓶㉁ᙧᡂ࡜ᶵ⬟⥔ᣢ࡟㔜せ࡞㌿෗ᢚไᅉᏊ ࢩ࣏ࣥࢪ࣒࢘ࠕ⬻⚄⤒᝟ሗ◊✲ࡢ᭱๓⥺ࠖ2019.1.12 Ⲉᇛ┴ࡘࡃࡤ㸦⏘⥲◊㸧ࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕
1.

⏣୰ᬛᏊࠊ⣽ᕝ㞞ேࠊᩧ⸨㈗ᚿࠊす㐨㝯⮧ࠊ㛗㇂ᕝᡂேࠊᒸᡞᬕ⏕ ຍ㱋ᛶ⬻ᶵ⬟㞀ᐖ࡟
࠾ࡅࡿⓎ㐩ᮇせᅉࡢゎ᫂ ➨ 37 ᅇ᪥ᮏㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍ 2018.10.12㹼10.14 ໭ᾏ㐨ᮐᖠᕷ

2.

Tomoko Tanaka ࠊ Okado Haruo. The role of RP58 in the maintenance of cognitive function,
Neuro2018, ➨ 41 ᅇ᪥ᮏ⚄⤒⛉ᏛᏛ఍ 2018.7.26㹼7.29 රᗜ┴⚄ᡞᕷ

3.

Tomoko TanakaࠊOkado Haruo. The role of RP58 in the maintenance of cognitive function, 18th
WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY,  ᅜ 㝿 ⸆ ⌮ Ꮫ ఍
WPC2018 2018.7.1㹼7.6 ி㒔ᗓIII. ࡑࡢ௚ࡢⓎ⾲㸦ィ 7 ௳㸧1.

ᒸᡞᬕ⏕ 㒔❧ᡞᒣ㧗ᰯࢳ࣮࣒࣓ࢴ࢝ࣝ࡟࡚ㅮ₇ 2018.10.30 ᮾி㒔᪂ᐟ༊

2.

ᒸᡞᬕ⏕ 㤳㒔኱Ꮫ኱Ꮫ㝔ࡢኟᏘࢭ࣑ࢼ࣮㸦ㅮ⩏࡜ᐇ⩦㸧2018.9.5 ᮾி㒔3.

ᒸᡞᬕ⏕ࠊᖹ஭ᚿఙࠊ⏣୰ᬛᏊࠊ㧗ἑඞᏊ ་Ꮫ◊ኟࡢࢭ࣑ࢼ࣮ 2018.7.30㹼8.3 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ4.

ᒸᡞᬕ⏕ ⬻ࡢⓎ㐩ࢆไᚚࡍࡿ㌿෗ᢚไᅉᏊᮾ኱ᩍ㣴Ꮫ㒊ࢮ࣑ࢼ࣮ࣝ 2018.7.1 ᮾி㒔5.

ᖹ஭ᚿఙ 㑇ఏⓗ⬤ᙅᛶ࡜㣗⎔ቃࡢ⤌ࡳྜࢃࡏ࡟ࡼࡿ⢭⚄⑌ᝈⓎ⑕ࣔࢹ࣐ࣝ࢘ࢫࡢసᡂ
୰ኸ኱Ꮫ FLP ₇⩦≉ูㅮ₇ 2018.6.28 ᮾி㒔6.

ᒸᡞᬕ⏕ ⬻Ⓨ㐩࡟ᚲせ࡞㌿෗ᢚไᅉᏊ RP58 ୰ኸ኱Ꮫ FLP ₇⩦≉ูㅮ₇ 2018.6.28
ᮾி㒔

7.

ᖹ஭ᚿఙ ᖹᡂ 30 ᖺᗘᩥ㒊⛉Ꮫ┬᪂Ꮫ⾡㡿ᇦ◊✲࣭ⱝᡭᨭ᥼ᢏ⾡ㅮ⩦఍ཱྀ࣭㢌Ⓨ⾲ ᰤ㣴⎔ቃ࡟㉳ᅉࡍࡿ᪂ࡓ࡞⤫ྜኻㄪ⑕ࣔࢹ࣐ࣝ࢘ࢫࡢసᡂ࡜ࡑࡢⓎ⑕࣓࢝ࢽࢬ࣒ࡢ᳨ド
2018.9.7. 㛗㔝┴ⱴ㔝ᕷIV. ≉グ஦㡯࠙ᩍ⫱άືࠚ
1.

ᒸᡞᬕ⏕ ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔㐃ᦠᩍဨ2.

ᒸᡞᬕ⏕ 㤳㒔኱Ꮫᮾி኱Ꮫ㝔㠀ᖖ໅ᩍဨ－ 65 －

ࣉࣟࢪ࢙ࢡࢺྡ⚄⤒ᅇ㊰ᙧᡂࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Ohtaka-Maruyama C., Okamoto M., Endo K., Oshima M., Kaneko N., Yura K., Okado H., MiyataT., Maeda N. (2018). Synaptic transmission from subplate neurons controls radial migration of
neocortical neurons.

2.

Science 360, 313-317.

Furotani K, Kamimura K, Yajima T, Nakayama M, Enomoto R, Tamura T, Okazawa H, Sone M(2018). Suppression of the synaptic localization of a subset of proteins including APP partiallyameliorates phenotypes of the Drosophila Alzheimer’s disease model. PLos One 13, e0204048.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧
1.

୸ᒣ༓⛅ࠊ๓⏣ಙ᫂ (2018).ࠕࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥ࠿ࡽࡢࢩࢼࣉࢫఏ㐩ࡀ኱⬻⓶㉁ࡢ
ࡅࡿ⚄⤒⣽⬊⛣ືࢆไᚚࡍࡿࠖ⏕໬Ꮫ 91, 101-104.

2.

୸ᒣ༓⛅ࠊ๓⏣ಙ᫂ (2018).ࠕ⛣ືࢽ࣮ࣗࣟࣥ࡬ࡢࢩࢼࣉࢫఏ㐩ࡀᨺᑕ≧⚄⤒⣽⬊⛣ືࢆไᚚࡍࡿࠖᐇ㦂་Ꮫ 36, 2230-2233.

3.

๓⏣ಙ᫂ࠊ୸ᒣ༓⛅ (2018).ࠕࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥ࠿ࡽ⛣ືࢽ࣮ࣗࣟࣥ࡬ࡢࢩࢼࣉࢫ
ఏ㐩ࡣ኱⬻᪂⓶㉁࡟࠾ࡅࡿࢽ࣮ࣗࣟࣥࡢᨺᑕ≧⛣ືࢆไᚚࡍࡿࠖࣛ࢖ࣇࢧ࢖࢚ࣥࢫ᪂╔ㄽᩥࣞࣅ࣮ࣗ DOI: 10.7875/first.author.2018.053.
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1. ୸ᒣ༓⛅ࠕ኱⬻᪂⓶㉁ᙧᡂ࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢ᪂つࡢᶵ⬟ࠖ➨஧ᅇ࿴ග-⢭⚄⚄⤒᠓ヰ఍ࠕᇶ♏⚄⤒⛉Ꮫ࡜⮫ᗋ་Ꮫࡢ⼥ྜ࡟ࡼࡿ⬻ᶵ⬟࣭⢭⚄⚄⤒⑌ᝈࡢ⤫ྜⓗ⌮ゎࠖ
2018.8.25 㟼ᒸ┴⇕ᾏᕷ
2. ୸ᒣ༓⛅ࠕFunctional role of subplate neurons in neocortical development and evolutionࠖ㑇ఏ◊◊✲఍ࠕ့ங㢮⬻ࡢᶵ⬟ⓗ⚄⤒ᅇ㊰ࡢᵓ⠏࣓࢝ࢽࢬ࣒ࠖ2018.12.21 㟼ᒸ┴୕ᓥᕷࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

୸ᒣ༓⛅ࠕ့ங㢮኱⬻᪂⓶㉁ࡢⓎ⏕ࠊ㐍໬࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺᒙࡢᙺ๭࣮ࠖ࣡ࢡࢩࣙࢵ
ࣉ㸸ࠗ⬻Ⓨ⏕ࣉࣟࢢ࣒ࣛࡢ」㞧໬࡜ࠊࡑࡢ㐍໬࠘➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.29⚄ዉᕝ┴ᶓ὾ᕷ㸦࣮࣡ࢡࢩࣙࢵࣉ࣮࢜࢞ࢼ࢖ࢨ࣮㸧

2.

㔠Ꮚ஀ឡࠊ୸ᒣ༓⛅ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ࠕⓎ⏕ᮇ኱⬻᪂⓶㉁ࡢࢧࣈࣉ࣮ࣞࢺᒙ࡟࠾࠸࡚ ECM
㛵㐃㑇ఏᏊࡀ⚄⤒⣽⬊ࡢ⛣ືࢆไᚚࡍࡿࠖ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 2018.11.28 ⚄ዉᕝ┴ᶓ὾ᕷ

－ 66 －

3.

⚄ᮧᆂுࠊ୸ᬛ㤶Ꮚࠊ୰⸨༤ࠊ⏤Ⰻᩗࠊ๓⏣ಙ᫂ࠕWingless ⃰ᗘ໙㓄ᙧᡂ࡟࠾ࡅࡿ࣊ࣃࣛ
ࣥ◲㓟ᚤ⣽ᵓ㐀ࡢᶵ⬟ゎᯒࠖ ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ 2018.9.24 ி㒔ᗓ

4.

୸ᬛ㤶Ꮚࠊ⚄ᮧᆂுࠊ୰⸨༤ࠊ๓⏣ಙ᫂ࠊ⏤Ⰻᩗࠕ࣊ࣃࣛࣥ◲㓟ᚤ⣽ᵓ㐀࡟ࡼࡿ Wingless⃰ᗘ໙㓄ࡢไᚚࠖ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ 2018.9.24 ி㒔ᗓ

5.

Ohtaka-Maruyama C, Okamoto M, Endo K, Oshima M, Kaneko N, Yura K, Okado H, Miyata T,
Maeda N “Synaptic transmission from subplate neurons controls radial migration of neocorticalneurons” Gordon Research Conference “Neural Development”  2018.7.30

6.

Newport, USA

Ohtaka-Maruyama C, Okamoto M, Endo K, Oshima M, Kaneko N, Yura K, Okado H, Miyata H,
Maeda N “Synaptic transmission from subplate neurons controls radial migration of neocorticalneurons” Joint Annual Meeting of 51st JSDB and 70th JSCB 2018.6.8 Tokyo,Japan

7.

Ohtaka-Maruyama C “Synaptic transmission from subplate neurons controls radial migration of
neocortical neurons.” 22nd Biennial Meeting of the International Society for Developmental
Neuroscience 2018.5.24 Nara,Japan

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 2 ௳㸧
1.

୸ᒣ༓⛅ A novel reguratory mechanism of radial neuronal migration via synaptic transmission
from subplate neurons 㤳㒔኱ࣂ࢖࢜ࢥࣥࣇ࢓ࣞࣥࢫ 2018. 11.16 ᮾி㒔ඵ⋤Ꮚᕷ

2.

୸ᒣ༓⛅ ኱⬻⓶㉁ᙧᡂ࡟࠾ࡅࡿࢧࣈࣉ࣮ࣞࢺࢽ࣮ࣗࣟࣥࡢ᪂つࡢᶵ⬟ ➨ 29 ᅇከᦶ࢟ࣕࣥࣃࢫ⚄⤒࢝ࣥࣇ࢓ࣞࣥࢫ 2019.3.1 ᮾி㒔ᗓ୰ᕷ

IV. ≉グ஦㡯࠙᪂⪺ሗ㐨ࠚ
1.

᪥ᮏ⤒῭᪂⪺ 2018 ᖺ 4 ᭶ 20 ᪥ࠕ့ங㢮ࠊ኱⬻ࡢⓎ㐩ゎ᫂ 㒔་Ꮫ⥲◊࡞࡝ࠖ2.

᪥⤒⏘ᴗ᪂⪺ 2018 ᖺ 4 ᭶ 20 ᪥ࠕ⫾ඣࡢ⬻Ⓨ㐩 ௙⤌ࡳゎ᫂ 㒔་Ꮫ⥲◊࡞࡝ࠊ့ங㢮࡛ࠖ

3.

᪥หᕤᴗ᪂⪺ 2018 ᖺ 4 ᭶ 20 ᪥ࠕ⫾⏕ᮇࡔࡅࡢ⚄⤒⣽⬊㛵୚ ့ங㢮⬻ᵓ㐀ᙧᡂ 㒔་Ꮫ⥲◊ࡀゎ᫂ࠖ

4.

⛉Ꮫ᪂⪺ 2018 ᖺ 4 ᭶ 27 ᪥ࠕ့ங㢮ᅛ᭷ࡢࢽ࣮ࣗࣟࣥ ኱⬻᪂⓶㉁ᙧᡂࡢ㘽 㔜せ࡞ಙྕⓎಙ 㒔་Ꮫ◊ࡀゎ᫂ࠖ

࠙ཷ㈹ࠚ
1. ᖹᡂ 30 ᖺᗘᮾி㒔⚟♴ಖ೺ᒁ㛗㈹ 2019 ᖺ 2 ᭶ࠕ኱⬻⓶㉁ᙧᡂࡢ᪂つࡢ௙⤌ࡳࡢゎ᫂ࠖ୸ᒣ༓⛅－ 67 －

ࣉࣟࢪ࢙ࢡࢺྡ

ᚰࡢ೺ᗣࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 26 ௳㸧
1.

*Nishida A, Ando S, Yamasaki S, Koike S, (14 ே␎), Kasai K, Okazaki Y. A randomized controlled
trial of comprehensive early intervention care in patients with first-episode psychosis in Japan: 1.5year outcomes from the J-CAP study. J Psychiatr Res, 102: 136-141. 20182.

Yamasaki S, Ando S, Richards M, (6 ே␎), Arai M, Okado H, Endo K, Hiraiwa-Hasegawa M, Kasai
K, *Nishida A. Maternal diabetes in early pregnancy, and psychotic experiences and depressive
symptoms in 10-year-old offspring: a population-based birth cohort study. Schizophr Res, 206: 5257. 20193.

*Okumura Y, Yamasaki S, Ando S, Usami M, Endo K, Hiraiwa-Hasegawa M, Kasai K, Nishida A.
Psychosocial burden of undiagnosed persistent ADHD symptoms in 12-year-old children: A
population-based birth cohort study. J Atten Disord, in press

4.

*Ando S, Usami S, Matsubayashi T, Ueda M, Koike S, Yamasaki S, Fujikawa S, Sasaki T, HiraiwaHasegawa M, Patton G, Kasai K, Nishida A. Age relative to school class peers and emotional wellbeing in 10-year-olds. PLoS One, 14(3):e0214359. 20195.

Ando S, *Nishida A, Yamasaki S, Koike S, Morimoto Y, Hoshino A, Kanata S, Fujikawa S, Endo K,
Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K; TTC Scientific and Data Collection Team.
Cohort Profile: The Tokyo Teen Cohort study (TTC). Int J Epidemiol, in press

6.

Okada N, Yahata N, Koshiyama D, (10 ே␎), Endo K, Yamasaki S, Ando S, Nishida A, HiraiwaHasegawa M, Edden RAE, Barker PB, Sawa A, *Kasai K. Neurometabolic and functional
connectivity basis of prosocial behavior in early adolescence. Sci Rep, 9(1): 732, 20197.

*Okada N, Ando S, (26 ே␎), Endo K, Yamasaki S, Nishida A, Hiraiwa-Hasegawa M, Bundo M,
Iwamoto K, Tanaka SC, Kasai K. Population-neuroscience study of the Tokyo TEEN Cohort (pnTTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent
psychological and behavioral development. Psychiatry Clin Neurosci, in press

8.

*Niimura J, Nakanishi M, Okumura Y, Kawano M, Nishida A. Effectiveness of 1-day traumainformed care training programme on attitudes in psychiatric hospitals: A pre-post study. Int J Ment
Health Nurs. in press

9.

Shimodera S, Koike S, Ando S, Yamasaki S, Endo K, Fujito R, Iijima Y, Yamamoto Y, Morita M,
Sawada K, Ohara N, Okazaki Y, *Nishida A. Lithium levels in tap water and psychotic experiences
in a general population of adolescents. Schizophr Res, 201: 294-298. 2018

10. Okada N, Yahata N, Koshiyama D, (10 ே␎), Endo K, Yamasaki S, Ando S, Nishida A, HiraiwaHasegawa M, *Kasai K. Abnormal asymmetries in subcortical brain volume in early adolescentswith subclinical psychotic experiences. Transl Psychiatry, 8(1):e254. 201911. *Ando S, Nishida A, Usami S, Koike S, Yamasaki S, Kanata S, Fujikawa S, Furukawa TA, Fukuda
M, Sawyer S, Hiraiwa-Hasegawa M, Kasai K. Help-seeking intention for depression in early－ 68 －

adolescents: associated factors and sex difference. J Affect Disord, 238: 359-365. 2018
12. *Iijima Y, Okumra Y, Yamasaki S, Endo K, (4 ே␎), Nakanishi M, Koike S, Furukawa TA, HiraiwaHasegawa M, Kasai K, Nishida A. Response inhibition and anxiety in adolescents: Results from a
population-based community sample. J Affect Disord, 246:89-95, 201913. *Yamasaki S, Usami S, Sasaki R, Koike S, Ando S, Kitagawa Y, Matamura M, Fukushima M,
Yonehara H, Foo JC, Nishida A, Sasaki T. The association between changes in depression/anxiety
and trajectories of psychotic-like experiences over a year in adolescence. Schizophr Res, 195: 149153. 2018
14. Morimoto Y, *Yamasaki S, Ando S, Koike S, Fujikawa S, Kanata S, Endo K, Nakanishi M, Hatch
SL, Richards M, Kasai K, Hiraiwa-Hasegawa M, *Nishida A. Purpose in life and tobacco use amongcommunity-dwelling mothers of early adolescents. BMJ Open. 8(4): e020586. 2018
15. Kurosawa K, *Terao T, Kanehisa M, Shiotsuki I, Ishii N, Takenaka R, Sakamoto T, Matsukawa T,
Yokoyama K, Ando S, Nishida A, Matsuoka Y. Naturally absorbed polyunsaturated fatty acids,
lithium, and suicide-related behaviors: A case-controlled study. J Affect Disord. 241: 200-205. 2018
16. *Fujikawa S, Ando S, Nishida A, Usami S, Koike S, Yamasaki S, (3 ே␎), Sasaki T, Furukawa TA,
Hiraiwa-Hasegawa M, Kasai K. Disciplinary slapping is associated with bullying involvement
regardless of warm parenting in early adolescence. J Adolesc 68: 207-216. 2018
17. *Nakanishi M, Tanaka S, Kurokawa G, Ando S, Yamasaki S, Fukuda M, Takahashi K, Kojima T,
Nishida A. Inhibited autonomy for promoting physical health: a qualitative analysis of narratives
from persons living with severe mental illness. BJPsych Open, 5(1):e10.
18. *Nakanishi M, Hirooka K, Imai Y, Inoue S, Yukari Y, Katayama C, (5 ே␎), *Nishida A. Dementia
care competence among care professionals and reduced challenging behavior of home dwellingpersons with dementia: a pre- and post-intervention data analysis. J Alzheimers Dis 64, 515-523.
2018
19. *Nakanishi M, Endo K, Hirooka K, Nakashima T, (3 ே␎), Nägga K, Nishida A. Dementia
behaviour management program at home: impact of a palliative care approach on care managers andprofessional caregivers of home care services. Aging Ment Health 22, 1057-1068. 2018
20. *Hirooka K, Nakanishi M, Fukahori H, Nishida A. Hospital death in dementia patients and regional
provision of palliative and end-of-life care: National patient data analysis. Cogent Med 5, e1483097.
2018.
21. *Nakanishi M, Yamasaki S, Nishida A. In-hospital dementia-related deaths following
implementation of the national dementia plan: observational study of national death certificates from1996 to 2016. BMJ Open, 8(12):e023172, 2018
22. *Nakanishi M, Endo K, Ando S, Nishida A. The Impact of Suicide Prevention Act (2006) on
Suicides in Japan. Crisis, in press
23. *Nakanishi M, Okumura Y, Ogawa A. Physical restraint to patients with dementia in acute physicalcare settings: Effect of the financial incentive to acute care hospitals. Int Psychogeriatr 30, 9911000. 201824. Sakata N, *Okumura Y, Fushimi K, Nakanishi M, Ogawa A. Dementia and risk of 30-day
readmission in older adults after discharge from acute care hospitals. J Am Geriatr Soc 66, 871-878.
2018－ 69 －

25. *Nakanishi M, Tei-Tominaga M. The association between quality improvement initiatives in dementia
care and supportive psychosocial work environments in nursing homes. Healthcare 6, 44. 2018
26. *Tei-Tominaga M, Nakanishi M. The influence of supportive and ethical work environments on
work-related accidents, injuries and serious psychological distress among hospital nurses. Int J
Environ Res Public Health 15, 240. 2018ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧
1.

す⏣῟ᚿࠊబࠎᮌྖࠊୗᑎಙḟࠊᒸᓮ♸ኈ ᛮ᫓ᮇ࣓ࣥࢱࣝ࣊ࣝࢫ␿Ꮫㄪᰝ㸸୕㔜࣭㧗▱኱つᶍ␿Ꮫࣉࣟࢪ࢙ࢡࢺࡢᡂᯝ. ᪥ᮏ♫఍⢭⚄་Ꮫ఍㞧ㄅ, 27 :175-180, 20182.

Ᏻ⸨ಇኴ㑻ࠊす⏣῟ᚿࠊᒣᓮಟ㐨ࠊ㛗㇂ᕝ┾⌮Ꮚࠊ➟஭ΎⓏ ᮾிࢸ࢕࣮ࣥࢥ࣮࣍ࢺ. ᪥ᮏ♫఍⢭⚄་Ꮫ఍㞧ㄅ 27 :181-187, 20183.

*Okumura Y, Usami M, (4 ே␎), Fujita J, Iida J. Prevalence, incidence, and persistence of ADHD
drug use in Japan. Epidemiol Psychiatr Sci. doi: 10.1017/S2045796018000252. in press.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

Nishida A. Personalized value in adolescence. International Symposium on Adolescent Health andPersonalized Value 2018, Plenary Session. 2018.11.28 Tokyo, Japanࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
1.

୰す୕᫓ࠊዟᮧὈஅࠊᑠᕝᮅ⏕ ୍⯡ᛴᛶᮇ⑓㝔࡟࠾ࡅࡿㄆ▱⑕ేⓎᝈ⪅ࡢࢣ࢔: ඲ᅜᶓ᩿ㄪ
ᰝ ➨ 69 ᅇ᪥ᮏ⪁ᖺ་Ꮫ఍㛵ᮾ⏥ಙ㉺ᆅ᪉఍ 2019.3.2 ៞᠕⩏ሿ኱Ꮫ⑓㝔኱఍㆟ᐊ ᮾி㒔

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯1.

す⏣῟ᚿ㸸ୡ⏣㇂༊ ㄆ▱⑕᪋⟇ホ౯ጤဨ఍ ጤဨ

2.

す⏣῟ᚿ㸸AMED ᡓ␎ⓗᅜ㝿⬻⛉Ꮫ◊✲᥎㐍ࣉࣟࢢ࣒ࣛㄢ㢟ホ౯ጤဨ఍ ጤဨ

3.

ᒣᓮಟ㐨㸸ୡ⏣㇂༊ Ꮚ࡝ࡶ࣭ⱝ⪅ᨭ᥼༠㆟఍ ᛮ᫓ᮇ㟷ᖺᮇ⢭⚄ಖ೺㒊఍ ጤဨ4.

᪂ᮧ㡰Ꮚ㸸ཌປ┬࣭⢭⚄㞀ᐖᆅᇦໟᣓࢣ࢔ࢩࢫࢸ࣒ࡢᵓ⠏ᨭ᥼஦ᴗᗈᇦ࢔ࢻࣂ࢖ࢨ࣮

࣓࠙ࢹ࢕࢔㛵㐃ࠚ1.

す⏣῟ᚿ㸸ᮅ᪥᪂⪺㸦2018.7.4 ᮅห㸸⪔ㄯ㸧ࠕㄆ▱⑕㸸Ꮩ❧⏕ࡲ࡞࠸௙⤌ࡳ኱஦ࠖ2.

す⏣῟ᚿࠊᒣ㷂ಟ㐨㸸ᮅ᪥᪂⪺㸦2018.7.13 ࢹࢪࢱࣝ㸧ࠕ⤫ྜኻㄪ⑕ࠊึᮇ࡟ᡭཌ࠸ࢣ࢔࡛
⑕≧Ᏻᐃࠖ

3.

す⏣῟ᚿࠊ୰す୕᫓㸸ᮅ᪥᪂⪺㸦2018.9.5 ᮅห㸧ࠕㄆ▱⑕ࠊ⸆࡟㢗ࡽࡎࢣ࢔඘ᐇࠖ

4.

す⏣῟ᚿ㸸NHK ࢡ࣮ࣟࢬ⌧௦ࣉࣛࢫࠕㄆ▱⑕ࡢ⛉Ꮫⓗ௓ㆤ᭱๓⥺ࠖ㸦2019.1.10㸧

－ 70 －

ࣉࣟࢪ࢙ࢡࢺྡ

⤫ྜኻㄪ⑕ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, Vincent De Andrade, Francesco De
Carlo, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima
K, Itokawa M, Arai M. Three-dimensional alteration of neurites in schizophrenia. Translational
Psychiatry 2019 9:85.

2.

Yamasaki S, Ando S, Richards M, Hatch SL, Koike S, Fujikawa S, Kanata S, Endo K, Morimoto Y,
Arai M, Okado H, Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai, K, Nishida A. Maternal
diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old
offspring: A population-based birth cohort study. Schizophr Res. 2018 Dec 26. pii: S09209964(18)30704-7.

3.

Kushima I, (34 ྡ␎), Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami
M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi
Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H,
Ishitobi M, Ormori T, Mumata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka
K, Goto YI, Inagaki M, Hashimoto N, kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K,
Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative Analyses of Copy-Number Variation inAutism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.
Cell Rep. 2018 Sep 11;24(11):2838-2856.

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Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, Sasaki T, Ohmori T, Okamoto Y,
Kawasaki H, Shimodera S, Kato T, Yoneda H, Yoshimura R, Iyo M, Matsuda K, Akiyama M,
Ashikawa K, Kashiwase K, Tokunaga K, Kondo K, Saito T, Shimasaki A, Kawase K, Kitajima T,
Matsuo K, Itokawa M, Someya T, Inada T, Hashimoto R, Inoue T, Akiyama K, Tanii H, Arai H,
Kanba S, Ozaki N, Kusumi I, Yoshikawa T, Kubo M, Iwata N. A genome-wide association study
identifies two novel susceptibility loci and trans population polygenicity associated with bipolar
disorder. Mol Psychiatry. (2018) 23, 639-647.

5.

Itokawa M, Miyashita M, Arai M, Dan T, Takahashi K, Tokunaga T, Ishimoto K, Toriumi K,
Ichikawa T, Horiuchi Y, Kobori A, Usami S, Yoshikawa T, Amano N, Washizuka S, Okazaki Y,
Miyata T. Pyridoxamine, A Novel Treatment For Schizophrenia With Enhanced Carbonyl Stress.
Psychiatry Clin Neurosci. 2018 Jan;72(1):35-44.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 19 ௳㸧

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1.

⣒ᕝᫀᡂ ⮚ჾᶵ⬟ㄽ࡟ࡼࡿ㒊ရࡢ⛉Ꮫ̺ᚰࡣ࡝ࡇࡲ࡛ࢱࣥࣃࢡ㉁࡞ࡢ࠿̺
PSYCHIATRY ⢭⚄⛉ VOL.34 No.3:298-305, 20192.

⣒ᕝᫀᡂ ᚰࡢ⑓࡜ࡣ࡞࡟࠿㸫⭊࡟ⴠࡕࡿ≀ㄒࡀᅇ᚟ࢆࡶࡓࡽࡍ. ᭶หࡳࢇ࡞ࡡࡗ࡜. 3 ᭶
ྕ:6-7, 2019 March

3.

᪂஭ㄔࠊᐑୗගᘯࠊྜྷᕝⲁࠊ㕥ᮌ୍ᾈࠊ㫽ᾏ࿴ஓࠊᇼෆὈỤࠊ⣒ᕝᫀᡂ ࣅࢱ࣑ࣥ B6 ࡜⤫ྜኻㄪ⑕㸬⮫ᗋ⢭⚄་Ꮫ 48(1): 63-73, 2019.

4.

᪂஭ㄔ. JMARS News Letter vol.18, Dec. 4, 2018࠙௻⏬࣭⦅㞟ࠚ[2018/12/18]

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Mizutani R, (15 ྡ ␎ ), Itokawa M, Arai M. Three-dimensional alteration of neurons in
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Mizutani R, Saiga R, Takekoshi S, Inomoto C, Nakamura N, Arai M, Oshima K, Itokawa M, (6 ྡ␎). Spatial Resolution of Pre-reconstruction Raw Images and their Nano-CT Slices. Microsc.
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⣒ᕝᫀᡂ ࢖ࢽࢩ࢚࣮ࢩࣙࣥ࡜ࡋ࡚ࡢ⑓(10)ㄒࡾࡢ⛉Ꮫ ࡇࡇࢁࡢ⛉Ꮫ No.201 ⢭⚄ 117121, 2018. ௚ 5 ௳

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⣒ᕝᫀᡂ 17 ᖺ๓ࡢࡇ࡜. 50 ᖺࡢ࠶ࡺࡳ̺㞟࠸Ꮫࡧࡘ࡞ࡀࡿ࠶ࡋࡓ̺ୡ⏣㇂ࡉࡃࡽ఍. 5-6,
2018 October

9.

⣒ᕝᫀᡂ ➨ 8 ❶ ⤫ྜኻㄪ⑕.⢭⚄ಖ೺་⒪⚟♴ⓑ᭩ 2018/2019̺ከᵝᛶ࡜ໟᣓᛶࡢᵓ⠏̺ 152, 2018 October

10. ⣒ᕝᫀᡂ ேࡣ࡞ࡐ⑓ࢆᚓࡿࡢ࠿̺࢖ࢽࢩ࢚࣮ࢩࣙࣥ࡜≀ㄒ̺ ➨ 58 ᅇ JCMA ඲ᅜ኱఍ inᚚẊሙ ᢒ㘓㞟ࠕ஭῝ඵ㔜ࡀ㑇ࡋࡓࡶࡢ㑇ࡋࡓ࠿ࡗࡓࡶࡢࠖ10—11, 2018 ᖺ 9 ᭶
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English Edition 15 Touchigng Recovery Episodes June 2018 Issue
12. ⣒ᕝᫀᡂ ಙ㛗࡜༡ᴟ㉺෤㝲 ̺㑇ఏ་Ꮫ◊✲ᐊࡢṌࡳϨ2018 ᖺ 7 ᭶

13. ᪂஭ㄔ ⤫ྜኻㄪ⑕⸆≀἞⒪࢞࢖ࢻ㸸ᝈ⪅ࡉࢇ࣭ࡈᐙ᪘࣭ᨭ᥼⪅ࡢࡓࡵ࡟ ୍⯡♫ᅋἲே᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⦅㞟㸪ࡌ࡯࠺㸦᭩⡠㸧2018 ᖺ 8 ᭶ 30 ᪥Ⓨ⾜14. ⣒ᕝᫀᡂࠊᐑୗගᘯࠊ᪂஭ㄔ ⤫ྜኻㄪ⑕ࡢศᏊ⑓ែ㸫࣓࢟ࣛࡢ⛉Ꮫ㸫 ≉㞟 I ⤫ྜኻㄪ⑕◊✲᭱๓⥺㸪⢭⚄⛉㸪32(3):181-188, 201815. ⣒ᕝᫀᡂ ᚰࡣ࡝ࡇࡲ࡛⬻࡞ࡢࡔࢁ࠺࠿~⤫ྜኻㄪ⑕◊✲ࡢ 30 ᖺ~ 㒆ᒣ⢭⚄་⒪ ➨ 32
ྕ 2018 ᖺ 5 ᭶
16. ⣒ᕝᫀᡂ ⬻࡜⬻௨እࡢᅇ᚟. ᚰࡢࣜࣁࣅࣜࠕᴦᴦ㎰ᅬࠖᚰࢆᡴࡘ㜚⑓࢚ࣆࢯ࣮ࢻ 15 ヰ
04-2018 ᨵゞ∧.
17. ᪂஭ㄔ ⏕ά⩦័࡜⢾໬࣭㓟໬ࢫࢺࣞࢫࡢ┦஫స⏝ࡀ୺య౯್ࡢᙧᡂ࡜ᨵ⦅࡟୚࠼ࡿᙳ
㡪㸬᪂Ꮫ⾡㡿ᇦ◊✲㸪⬻࣭⏕ά࣭ே⏕࠿ࡽࡢ⥲ྜⓗ⌮ゎ࡟ࡶ࡜࡙ࡃᛮ᫓ᮇ࠿ࡽࡢ୺య౯್
ⓎᒎᏛ Newsletter, vol. 2, May, 2018 ௚ 1 ௳
18. ᐑୗගᘯࠊ㧗ᶫඞᫀࠊ▼ᮏె௦ࠊᚨỌኴ㑻ࠊᇼෆὈỤࠊ㫽ᾏ࿴ஓࠊ㕥ᮌ୍ᾈࠊᑠᇼᬗᏊࠊ
ᒸᓮ♸ኈࠊ㰻⸨ṇᙪࠊ⣒ᕝᫀᡂࠊ᪂஭ㄔ ࢝ࣝ࣎ࢽࣝࢫࢺࣞࢫࡀஹ㐍ࡍࡿ⤫ྜኻㄪ⑕ᝈ⪅࡟ᑐࡍࡿࣆࣜࢻ࢟ࢧ࣑ࣥࡢ἞⒪ྍ⬟ᛶ ⢭⚄⚄⤒Ꮫ㞧ㄅ 120(10):861-867, 201819. ᇼෆὈỤࠊ᳃ᬡࠊ᪂஭ㄔࠊ⣒ᕝᫀᡂ iPS ⣽⬊ࢆ⏝࠸ࡓ⢭⚄⑌ᝈ⑓ែࣔࢹࣝࡢྍ⬟ᛶ࡜ㄢ㢟 ⢭⚄⛉⮫ᗋ Legato. 4(1): 21-24, 2018

－ 72 －

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 3 ௳㸧
1.

⣒ᕝᫀᡂ ⢭⚄⑌ᝈ࡜ࡣఱ࠿㸫ࣔࣀ࡜ࢥࢺࡢ⛉Ꮫ㸫 ➨ 7 ᅇ᪥ᮏ⢭⚄⛉་Ꮫ఍Ꮫ⾡኱఍.
2018.10.4 ࣍ࢡࢺᩥ໬࣮࣍ࣝ 㛗㔝┴

2.

⣒ᕝᫀᡂ ࡞ࡐ⢭⚄⑌ᝈ◊✲ࡣ㞴⯟ࡍࡿࡢ࠿㸫ࣔࣀ࡜ࢥࢺࡢ⛉Ꮫ㸫 ➨ 114 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍. 2018.6.22 ⚄ᡞ࣏࣮ࢺࣆ࢔࣍ࢸࣝ රᗜ┴⚄ᡞᕷ

3.

᪂஭ㄔ ࢢࣜࢣ࣮ࢩࣙࣥ◊✲ࡢ₻ὶ㸸⤫ྜኻㄪ⑕࡟࠾ࡅࡿࢢࣜࢣ࣮ࢩࣙࣥ Schizophrenia
and Advanced glycation end products ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ 2018.9.24 ி㒔ᗓࡑࡢ௚ 㸦ィ 27 ௳㸧⮬⏤ᥖ㍕
1.

᪂஭ㄔ Pyridoxamine, a novel treatment for negative symptoms of schizophrenia.

Neuroscience

2018 2018.11.3㹼11.7 San Diego,U.S.A.
2.

ᇼෆὈỤ Susceptibility to carbonyl stress in schizophrenia derived neural cellsderived neuralcells㸬 Neuroscience 2018 2018.11.3㹼11.7 San Diego,U.S.A.

3.

ᇼෆὈỤ 2017 PSGCA ఍㆟ࡢሗ࿌࡜࢔ࢪ࢔ኴᖹὒᆅᇦ࡟࠾ࡅࡿ㑇ఏ࢝࢘ࣥࢭ࣮ࣛࡢ༠ຊࡢ㔜せᛶ ᪥ᮏே㢮㑇ఏᏛ఍኱ 63 ᅇ኱఍ 2018.10.10㹼10.13 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ
┴ᶓ὾ᕷ

4.

஭ୖᬛᏊ ⢭⚄⛉࡟࠾ࡅࡿ࣮ࣚ࢞⒪ἲࡢࡇࡇࢁࡢ཯ᛂࠊ࠿ࡽࡔࡢ཯ᛂ㹼⏕⌮Ꮫ࣭⏕໬Ꮫ࣭⢭⚄་ᏛࡢどⅬ࠿ࡽ ➨ 22 ᅇ⤫ྜ་⒪Ꮫ఍ 2018.10.7㹼10.8 ໭ᾏ㐨ᮐᖠᕷ

5.

⣒ᕝᫀᡂ ⢭⚄⑌ᝈ࡜ࡣఱ࠿㸫ࣔࣀ࡜ࢥࢺࡢ⛉Ꮫ㸫. ➨ 7 ᅇ᪥ᮏ⢭⚄⛉་Ꮫ఍Ꮫ⾡኱఍.
2018.10.4 ࣍ࢡࢺᩥ໬࣮࣍ࣝ 㛗㔝┴6.

ᇼෆὈỤ Utility of patients derived induced pluripotent stem cells(IPSCs) for schizophrenia
disease model㸬 18th WPA World Congress of Psychiatry 2018.9.27㹼9.30 Mexico City

7.

ยࡉࡃࡽࠊ
㸦4 ྡ␎㸧
ࠊ᪂஭ㄔࠊ኱ᓥ೺୍ࠊ⣒ᕝᫀᡂ㸦10 ྡ␎㸧ࠊỈ㇂㝯ኴ ⤫ྜኻㄪ⑕࡟
࠾ࡅࡿ⚄⤒⣽⬊ࡢᵓ㐀ኚ໬㸬➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ 2018.9.25 ி㒔ᗓ

8.

᪂஭ㄔ A challenging step forward in the development of truly pre-emptive sugar chain information
trajectory㸬➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ 2018.9.24 ி㒔ᅜ㝿఍㤋 ி㒔ᗓ9.

᪂஭ㄔ Schizophrenia and Advanced glycation end products ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ 2018.9.24
ி㒔ᅜ㝿఍㤋 ி㒔ᗓ

10. ⣒ᕝᫀᡂ Rare variant ࢆ㉳Ⅼ࡜ࡍࡿⓎ㐩㞀ᐖ࣭⤫ྜኻㄪ⑕ࡢデ᩿ἲ࣭἞⒪ἲࡢ㛤Ⓨ ᖹᡂ
30 ᖺ AMED ෌⏕་⒪◊✲஺ὶ఍.TKP 2018.9.12 ࣮࢞ࢹࣥࢩࢸ࢕ရᕝ ᮾி㒔
11. Arai M, Miyashita M, Dan T, Toriumi K, Horiuchi H, Suzuki K, Miyata T, Itokawa M.
Pyridoxamine, a novel treatment for negative symptoms of schizophrenia. 13th International
Symposium on The Maillard reaction, 2018.9.10㹼9.13

Montreal, Canada

12. Toriumi K, Miyashita M, Horiuchi Y,㸦5 ྡ␎㸧, Itokawa M, Arai M. Effect of vitamin B6 deficiency
on mouse behavior and monoaminergic system. 13th International Symposium on The Maillard
reaction, 2018.9.10㹼9.13 Montreal, Canada
13. Itokawa M. Schizophrenia paradox –material or an event-. WFSBP/JSBP Joint Symposium㸸Frontier
symposium on schizophrenia and mood disorders. 2018.9.8. Kobe International Conference Center,
Kobe－ 73 －

14. Itokawa M. Chairs. WFSBP2018㸸Animal Mode/Molecular Neurobiology/Genetics. KobeChamberof Commerce and Industry,Kobe 2018.9.8 රᗜ┴⚄ᡞᕷ
15. Miyashita M, Suzuki K, Horiuchi Y, Toriumi K, 㸦8 ྡ␎㸧, Itokawa M, Arai M.  Carbonyl stressin mood disorder. ➨ 40 ᅇ᪥ᮏ⏕≀Ꮫⓗ⢭⚄་Ꮫ఍࣭➨ 61 ᅇ᪥ᮏ⚄⤒໬Ꮫ఍኱఍ 2018.9.6
⚄ᡞᅜ㝿఍㆟ሙ රᗜ┴⚄ᡞᕷ
16. ⣒ᕝᫀᡂ ⢭⚄⑌ᝈ࡜ࡣఱ࠿㸫ࣔࣀ࡜ࢥࢺࠊ⑓Ẽ࡜⑓Ẽ࡛࡞࠸ࡶࡢ㸫 ᮾி⢭⚄་Ꮫ఍➨28 ᅇ⏕ᾭᩍ⫱◊ಟ఍ࣉࣟࢢ࣒ࣛ 2018.7.14 ࢫࢸ࣮ࢩࣙࣥࢥࣥࣇ࢓ࣞࣥࢫᮾி ᮾி㒔༓௦⏣༊
17. Y Horiuchi,㸦3 ྡ␎㸧K Toriumi, N Obata, M Miyashita,㸦3 ྡ␎㸧, M. Arai. Susceptibility tocarbonyl stress in schizophrenia derived neural cells derived neural cells. Society for Neuroscience
2018,  2018.7.11 San Diego,CA, US
18. Itokawa M. Round Table Discussion:Good Partership. Pan-Asia Symposium on The Genetics Of
Brain Disorders. Shanghai, China[2018/7/10]
19. Itokawa M. Round Table Discussion:Good Partership. Pan-Asia Symposium on The Genetics Of
Brain Disorders. 2018.7.10 Shanghai, China
20. Itokawa M. Brain Disorder Research in Japan. Precision Medicine Strategy to Brain Disorders.
2018.7.9

Shanghai, China

21. ⣒ᕝᫀᡂ ࡞ࡐ⢭⚄⑌ᝈ◊✲ࡣ㞴⯟ࡍࡿࡢ࠿㸫ࣔࣀ࡜ࢥࢺࡢ⛉Ꮫ㸫 ➨ 114 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍ 2018.6.22 ⚄ᡞ࣏࣮ࢺࣆ࢔࣍ࢸࣝ රᗜ┴⚄ᡞᕷ22. ⣒ᕝᫀᡂ ࢩ࣏ࣥࢪ࣒࢘ 55 ᪥ᮏே◊✲⪅ࡀⓎಙࡋࡓ࢜ࣜࢪࢼࣝ࡞⤫ྜኻㄪ⑕⑓ែ௬ㄝࢆ
⤫ྜࡍࡿ. ➨ 114 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍Ꮫ⾡⥲఍. 2018.6.22 ⚄ᡞ࣏࣮ࢺࣆ࢔࣍ࢸࣝ රᗜ┴⚄ᡞᕷ㸦ྖ఍㸧23. ᇼෆὈỤ ࢚ࢡࢯ࣮࣒ゎᯒࡢ஧ḟⓗᡤぢ⤖ᯝ㛤♧ࡀ⾑⦕⪅ࡢங⒴᪩ᮇⓎぢ࡟᭷ຠࡔࡗࡓ 1⑕౛ ➨ 24 ᅇ᪥ᮏᐙ᪘ᛶ⭘⒆Ꮫ఍Ꮫ⾡㞟఍ 2018.6.8㹼6.9 ⚄ᡞࣇ࢓ࢵࢩ࣐࣮ࣙࣥࢺ
රᗜ┴⚄ᡞᕷ
24. K Suzuki, K Toriumi, Y Horiuchi, M Miyashita, M Itokawa, M. Arai. Behavioral phenotype ofglyoxalase 1 knockout mice. Society for Neuroscience 2018, 2018.6.11 San Diego,CA, US
25. ⣒ᕝᫀᡂ Rare Variant ࠿ࡽ㏕ࡿⓎ㐩㞀ᐖ࣭⤫ྜኻㄪ⑕ࡢデ᩿ἲ࣭἞⒪ἲࡢ㛤Ⓨ ᖹᡂ 30
ᖺᗘ⼥ྜ⬻➨ 1 ᅇศ⛉఍ 2018.5.12 ࢥࣥ࣋ࣥࢩ࣮࣒ࣙࣥࣝ AP ရᕝ ᮾி㒔
26. ᪂஭ㄔ ⏕ά⾜ື⩦័࡜⢾໬࣭㓟໬ࢫࢺࣞࢫࡢ┦஫స⏝ࡀ୺య౯್ࡢᙧᡂ࡜ᨵ⦅࡟୚࠼ࡿ
ᙳ㡪 ᪂Ꮫ⾡㡿ᇦ◊✲⌜఍㆟ 2018.5.12 ᮾி኱Ꮫ ᮾி㒔
27. M Arai, M. Miyashita, K. Toriumi, Y Horiuchi, A kobori, M Itokawa. Pyridoxamine, a novel
treatment for negative symptoms of schizophrenia. Society for Neuroscience 2018, 2018.5.11

San

Diego,CA, US
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 71 ௳㸧
1.

᪂஭ㄔ Beneficial life course intervention in critical and sensitive periods for glycation, oxidative
stress, and nutritional epidemiology㸦◊✲ᐊࢭ࣑ࢼ࣮㸪௻⏬࣭ᗙ㛗㸧2019.2.8

2.

᪂஭ㄔ Preventive medical research in areas of psychiatry, health, and social welfare㸦◊✲ᐊࢭ࣑ࢼ࣮㸪௻⏬࣭ᗙ㛗㸧2019.2.8

3.

᪂஭ㄔ ⏕⌮ᚰ⌮Ꮫ B㸭⚄⤒᝟ሗㄽ B ࠕ⤫ྜኻㄪ⑕◊✲࡟࠾ࡅࡿᇶ♏࡜⮫ᗋࡢࢫࢺ࣮ࣟ

－ 74 －ࢡࠖ ᮾὒ኱Ꮫ࠙ㅮ⩏ࠚ2018.12.21
4.

᪂஭ㄔ ࡇࡇࢁࡢከᵝᛶ࡜㐺ᛂࡢ⤫ྜⓗ◊✲ᶵᵓࠕ⤫ྜኻㄪ⑕◊✲࡟࠾ࡅࡿᇶ♏࡜⮫ᗋࡢࢫࢺ࣮ࣟࢡࠖᮾி኱Ꮫᩍ㣴Ꮫ㒊࠙ㅮ⩏ࠚ2018.12.14

5.

᪂஭ㄔ ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕࡜⤫ྜኻㄪ⑕ࡢࢤࣀ࣒ࢥࣆ࣮ᩘኚ␗ゎᯒ࡜ࡑࢀ࡟ᇶ࡙ࡃศ
Ꮚ⑓ែ◊✲㸪ஂᓥ࿘㸦ྡྂᒇ኱Ꮫ㧗➼◊✲㝔 ≉௵ຓᩍ㸧࠙㒔་Ꮫ◊ࢭ࣑ࢼ࣮㸪௻⏬࣭ᗙ㛗ࠚ
2018.11.26

6.

᪂ ஭ ㄔ  Comprehensive functional and structural glycomics in human neurodegenerative
disorders㸪㟷ᮌ୍ᘯ㸦Complex Carbohydrate Research Center, The University of Georgia㸪SeniorResearch Scientist㸧࠙㒔་Ꮫ◊ࢭ࣑ࢼ࣮㸪௻⏬࣭ᗙ㛗ࠚ2018.10.4

7.

⣒ᕝᫀᡂ ⢭⚄⛉་ࢆ 30 ᖺࡸࡗ࡚ࡳ࡚ ኱ศ኱Ꮫ་Ꮫ㒊≉ูㅮ₇ 2018.10.24 ኱ศ ௚
46 ௳

8.

㫽ᾏ࿴ஓ ศᏊ⚄⤒Ꮫࠕ⚄⤒ఏ㐩≀㉁ࠖ❧ᩍ኱Ꮫ⌮Ꮫ㒊ㅮ⩏ 2018.10.7 ᮾி㒔 ௚ 9 ௳

9.

ᐑୗගᘯࠕㄆ▱⑕࡟ࡘ࠸࡚ࠖㄆ▱⑕࢝ࣇ࢙ࠕ࢜ࣞࣥࢪࢻ࢔࠶ࡁࡋࡲࠖ2018.10.1 ᮾி㒔᫛ᓥ ௚ 5 ௳

10. ᪂஭ㄔ ⤫ྜኻㄪ⑕◊✲ࡢᇶ♏࡜⮫ᗋࡢࢡࣟࢫࢺ࣮ࢡ㸬ᮾி㒔❧ᯇἑ⑓㝔⢭⚄⛉་ᒁࢭ࣑ࢼ࣮ 2018.9.4 ᮾி㒔ୡ⏣㇂༊ ௚ 1 ௳
IV. ≉グ஦㡯－ 75 －

ࣉࣟࢪ࢙ࢡࢺྡ

࠺ࡘ⑓ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Bauer R㸦௨ୗ 61 ே␎㸧, Tatebayashi Y,㸦8 ே␎㸧㸦2018㸧 Internet use by older adults withbipolar disorder: international survey results. Int J Bipolar Disord 6:20.㸦ᰝㄞ᭷㸧

2.

Bauer M㸦௨ୗ 82 ே␎㸧, Tatebayashi Y,㸦11 ே␎㸧㸦2019㸧Association between solar insolation
and a history of suicide attempts in bipolar I disorder. J Psychiatr Res. 113:1-9.㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

஧ᮏᯇ㸦⳥ụ㸧ᑦ⨾ࠊ*ᴙᯘ⩏Ꮥ㸦2019㸧࠺ࡘ⑓࠿ࡽㄆ▱⑕࡬ࡢ⛣⾜ࡢ࣓࢝ࢽࢬ࣒㸦᪥ᮏㄒ⥲ㄝ㸧. Geriatric Medicine (⪁ᖺ་Ꮫ). 57:247-251.

2.

*ᴙᯘ⩏Ꮥ㸦2019㸧࠺ࡘ⑓࡜ㄆ▱⑕㸦᪥ᮏㄒ⥲ㄝ㸧. ⢭⚄⛉.

34:346-351.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

*ᴙᯘ⩏Ꮥࠊ஧ᮏᯇ㸦⳥ụ㸧ᑦ⨾ࠊᯇ⏣ⰾᶞࠊΏ㑓ⴌࠊ㟷ᮌ࿴ஂ (2018) ࠺ࡘ⑓࡜࢔ࣝࢶࣁ
࢖࣐࣮⑓ࡢ⏕≀Ꮫⓗඹ㏻ᇶ┙࡜ࡣ㸽 ➨ 114 ᅇ᪥ᮏ⢭⚄⚄⤒Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ㅮ₇2018.6.23 රᗜ┴⚄ᡞᕷࡑࡢ௚ 㸦ィ 3 ௳㸧⮬⏤ᥖ㍕
1.

*Tatebayashi Y, Kikuchi-Nihonmatsu N, Matsuda Y, Aoki K, Uchihara T (2019) Essential roles of
plexin-B3+ oligodendrocyte progenitor cells in the pathogenesis of Alzhimer’s disease. Alzheimer
Society International Congress (ASIC2019), 2019.2.18~21. San Francisco, USA.

2.

*Tatebayashi Y, Kikuchi-Nihonmatsu N, Matsuda Y, Uchihara T, Aoki K, Watanabe M (2018) Rolesof plexin-B3+ oligodendrocyte progenitor cells in the pathogenesis of Alzheimer’s disease. WFSBP
Asia Pacific Regional Congress of Biologica Psychiatry (WFSBP 2018 KOBE), Symposium
2018.9.7 Kobe,Japan

3.

*Tatebayashi Y, Kikuchi-Nihonmatsu N, Matsuda Y, Uchihara T (2018) FGF2 regulates amyloidbeta secretions in cultured oligodendrocyte progenitor cells from the adult rat hippocampus.
Alzheimer’s Association International Conference (AAIC2018), 2018.7.22 Chicago, USA－ 76 －

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧
1.

஧ᮏᯇ㸦⳥ụ㸧ᑦ⨾ࠊன⚽㌷ࠊᯇ⏣ⰾᶞࠊΏ㑓ⴌࠊ㟷ᮌ࿴ஂࠊᑠ⃝ಙᖾࠊ⠛ᓮࡓࡁᏊࠊ㏆⸨ࡦࢁࡳࠊᴙᯘ⩏Ꮥ (2019) ࢜ࣜࢦࢹࣥࢻࣟࢧ࢖ࢺ๓㥑⣽⬊ࡢ᪂つࢧࣈࢱ࢖ࣉ࡜ࡑࡢᶵ⬟(A novel subtype of adult oligodendrocyte progenitor cell: isolation and functional analysis). ᪥ᮏ⸆Ꮫ఍➨ 139 ᖺ఍. 2019.3.20㹼3.23 ༓ⴥ

2.

ᯇ⏣ⰾᶞࠊᴙᯘ⩏Ꮥ (2019) ♫఍ⓗࢫࢺࣞࢫ࡟ࡼࡾ᥋ゐᅇ㑊⾜ືࡸ╧╀␗ᖖࢆ࿊ࡍࡿ࠺ࡘ
⑓ື≀ࣔࢹࣝࡢᵓ⠏࡜ࡑࡢゎᯒ. ➨ 4 ᅇ TMED ࣇ࢛࣮࣒ࣛ 2019.3.13 ከᦶ⥲ྜ་⒪ࢭ
ࣥࢱ࣮࣭ᑠඣ⥲ྜ་⒪ࢭࣥࢱ࣮ ᮾி3.

ᯇ⏣ⰾᶞࠊᴙᯘ⩏Ꮥ (2018) ࠺ࡘ⑓ࣔࢹࣝື≀ࡢ⣅ゎᯒ࠿ࡽぢࡘ࠿ࡗࡓ⭠ෆ⣽⳦௦ㅰ⏘≀ࡢ╧╀ᨵၿຠᯝ. ᖹᡂ 30 ᖺᗘᡤෆ◊✲Ⓨ⾲఍ 2018.11.19 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ᮾி
ඃ⚽㈹ཷ㈹

4.

ᴙᯘ⩏Ꮥࠊ஧ᮏᯇ㸦⳥ụ㸧ᑦ⨾ࠊᯇ⏣ⰾᶞࠊΏ㑓ⴌࠊ㟷ᮌ࿴ஂ (2018) ㄆ▱⑕࡜࠺ࡘࡢ᪂
ࡋ࠸἞⒪ᡓ␎ JT ♫ෆ◊ಟ఍㸦ᣍᚅ㸧 2018.4.18 ኱㜰ᗓ㧗ᵳᕷIV. ≉グ஦㡯
1.

➨ 30 ᅇࢧ࢖࢚ࣥࢫ࢝ࣇ࢙ in ୖ໭ἑࠊ2019.3.10

2.

2018 ᖺᗘᡤෆ◊✲Ⓨ⾲఍➨ 1 㒊఍ ඃ⚽Ⓨ⾲⪅ ᯇ⏣ⰾᶞࠕ࠺ࡘ⑓ࣔࢹࣝື≀ࡢ⣅ゎᯒ࠿ࡽぢࡘ࠿ࡗࡓ⭠ෆ⣽⳦௦ㅰ⏘≀ࡢ╧╀ᨵၿຠᯝࠖ

－ 77 －

2018.11.19

ࣉࣟࢪ࢙ࢡࢺྡ

╧╀ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

*Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T,
Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y,
Takami M, Higashiyama Y, Miyake R, Kondo H, Fujimura Y, Tamura Y, Taniyama Y, Omata N,
Tanaka Y, Moriya S, Furuya H, Kato M, Kawamura Y, Otowa T, Miyashita A, Kojima H, Saji H,
Shimada M, Yamasaki M, Kobayashi T, Misawa R, Shigematsu Y, Kuwano R, Sasaki T, Ishigooka
J, Wada Y, Tsuruta K, Chiba S, Tanaka F, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K,
Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K. (2018)A variant at
9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia. J Hum Genetics,
63(12):1259-1267.

2.

Shimada M, *Miyagawa T, Toyoda H, Tokunaga K, Honda M. (2018)

An Epigenome-wide

association study of DNA methylation in narcolepsy: an integrated genetic and epigenetic approach.
Sleep 41(4) doi: 10.1093/sleep/zsy019.
3.

Ito W, *Honda M, Ueno T, Kato N. Hypersomnia with ADHD: a possible subtype of narcolepsy
type2. doi.org/10.1007/s41105-017-0139-1 Sleep Biol Rhythms 16(2)㸸205-210.

4.

*Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K,
Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. (2018) An
epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
doi: 10.1038/s10038-017-0382-y J Hum Genetics, 63(3):319-326.

5.

⩚⃈ᜨࠊᮏከ┿ (2018) ࢼࣝࢥࣞࣉࢩ࣮ᝈ⪅࡟࠾ࡅࡿ᪥୰ࡢ╀Ẽ࡟క࠺ᑐே㛵ಀࡢయ㦂ᵓ㐀 ⮫ᗋᚰ⌮Ꮫ 18(4):475-485.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 6 ௳㸧
1.

*Miyagawa T, Tokunaga K. (2019) Genetics of Narcolepsy. Hum Genome Variation Jan 8;6:4 doi:
10.1038/s41439-018-0033-7.

2.

Wada M, Mimura M, Noda Y, Takasu S, Plitman E, Honda M, Natsubori A, Ogyu K, Tarumi R,
Graff-Guerrero A, Nakajima S. (2018) Neuroimaging correlates of narcolepsy with cataplexy: A
systematic review. Neurosci Res, 142:16-29. doi: 10.1016/j.neures.2018.03.005.

3.

ᮏከ┿㸸╧╀ࡢ㉁࡜ࡣఱ࠿ In:య⫱ࡢ⛉Ꮫ Vol.68 No.11 2018 pp781-788,ᮥᯘ᭩㝔.

4.

ᮏከ┿㸸╧╀㞀ᐖ In:⢭⚄ಖ೺་⒪⚟♴ⓑ᭩ 2018/2019 ⦅㞟ဨ఍⦅ ⢭⚄ಖ೺་⒪⚟♴ⓑ᭩pp161,୰ኸἲつฟ∧ᰴᘧ఍♫.

5.

ᮏከ┿㸸ከᙬ࡞࣒ࣞ㛵㐃⑕≧࡜ඹᏑࡍࡿࢼࣝࢥࣞࣉࢩ࣮ࡢ⑕౛ In:╧╀ࡢデ࠿ࡓ ༓ⴥⱱ⦅ pp46-47,᪂⯆་Ꮫฟ∧♫(2019.2)

6.

ᮏከ┿㸸㑄ᘏᆺࡢࢡࣛ࢖ࢿ-ࣞࣅࣥ⑕ೃ⩌ In:╧╀ࡢデ࠿ࡓ ༓ⴥⱱ⦅ pp54-55,᪂⯆་Ꮫฟ
∧♫(2019.2)－ 78 －

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－ 80 －

ࣉࣟࢪ࢙ࢡࢺྡ

౫Ꮡᛶ⸆≀ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 13 ௳㸧
1.

Kotajima-Murakami H, Takano A, Ogai Y, Tsukamoto S, Murakami M, Funada D, Tanibuchi Y,
Tachimori H, Maruo K, Sasaki T, Matsumoto T, Ikeda K. Study of effects of ifenprodil in patientswith methamphetamine dependence: Protocol for an exploratory, randomized, double-blind,placebo-controlled trial. Neuropsychopharmacol Rep in press. ᰝㄞ᭷ doi: 10.1002/npr2.12050.

2.

Fujita M, Ide S, *Ikeda K. Opioid and non-dopamine reward circuitry and state-dependent
mechanisms. Ann NY Acad Sci in press. ᰝㄞ᭷ doi: 10.1111/nyas.13605.

3.

Hozumi J, *Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada
Y, Japanese TR-Cancer Pain research Group (2019) Resistin is a novel marker for postoperative pain
intensity. Anesth Analg 128(3):563-568. ᰝㄞ᭷ doi: 10.1213/ANE.0000000000003363.

4.

Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, De Andrade V, De Carlo F,
Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K,
Itokawa M, Arai M (2019) Three-dimensional alteration of neurites in schizophrenia. Transl
Psychiatry 9(1):85. ᰝㄞ᭷ doi: 10.1038/s41398-019-0427-4.

5.

Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu
Y, Uchino S, *Ikeda K (2019) Effects of rapamycin on social interaction deficits and gene expression
in mice exposed to valproic acid in utero. Mol Brain 12:3. ᰝㄞ᭷ doi: 10.1186/s13041-018-04232.

6.

Tanaka M, Sato A, Kasai S, Hagino Y, Kotajima-Murakami H, Kashii H, Takamatsu Y, Nishito Y,
Inagaki M, Mizuguchi M, Hall FS, Uhl GR, Murphy D, Sora I, *Ikeda K (2018) Brain
hyperserotonemia causes autism-relevant social deficits in mice. Mol Autism 9:60. ᰝㄞ᭷ doi:
10.1186/s13229-018-0243-3.

7.

Yokoshima Y, *Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H,
Azuma K, Tsuchida R, Yamada Y, Japanese TR - Cancer Pain Research Group (2018)

Gamma-

aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness toopioid analgesics in patients with cancer pain: An exploratory study. Neuropsychopharmacol Rep
38(4):175-181. ᰝㄞ᭷ doi: 10.1002/npr2.12030.
8.

Ide S, Ikekubo Y, Hua J, Takamatsu Y, Uhl GR, Sora I, *Ikeda K (2018) Reward-enhancing effectof methylphenidate is abolished in dopamine transporter knockout mice: a model of attention
deficit/hyperactivity disorder. Neuropsychopharmacol Rep 38:149-153.

ᰝ ㄞ ᭷

doi:

10.1002/npr2.12020.
9.

*Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine
SZ, Goldberg Y, Leucht S, Cipriani A (2018) Initial severity of major depression and efficacy of new
generation antidepressants: individual-participant data meta-analysis. Acta Psychiatr Scand
137:450-458. ᰝㄞ᭷ doi: 10.1111/acps.12886.

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10. *Fujita M, Hagino Y, Takamatsu Y, Shimizu Y, Takamatsu Y, Ikeda K, Hashimoto M (2018) Early
manifestation of depressive-like behavior in transgenic mice that express dementia with Lewy
bodies-linked mutant beta-synuclein. Neuropsychopharmacol Rep 38:95-97. ᰝ ㄞ ᭷

doi:

10.1002/npr2.12009.
11. Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T,
Hayashida M, Fukuda K, *Ikeda K (2018) Association between the rs7583431 single nucleotide
polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanylin the cold pain test. Neuropsychopharmacol Rep 38:86-91. ᰝㄞ᭷ doi: 10.1002/npr2.12012.
12. Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, *Ikeda K (2018)
Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene andperioperative analgesic use in cosmetic orthognathic surgery. Neuropsychopharmacol Rep 38:6774. ᰝㄞ᭷ doi: 10.1002/npr2.12010.
13. Narita S, Onozawa Y, Yoshihara E, Nishizawa D, Numajiri M, Ikeda K, *Iwahashi K (2018)
Association between N-methyl-D-aspartate receptor subunit 2B gene polymorphisms andpersonality traits in a young Japanese population. East Asian Arch Psychiatry 28:45-52. ᰝㄞ᭷
doi: 10.12809/eaap181712.
ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 3 ௳㸧
1.

Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, Andrade VD, Carlo FD, Takekoshi
S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K, Itokawa M,
Arai M (2018) Brain tissue fingerprints of schizophrenia and control individuals. Neurons andCognition (q-bio.NC); Biological Physics (physics.bio-ph) arXiv:1804.00404 [q-bio.NC]. ᰝㄞ᭷

2.

Ide S, Ikeda K (2018) Mechanisms of the antidepressant effects of ketamine enantiomers and their
metabolites. Biol Psychiatry 84:551-552. ᰝㄞ᭷ doi: 10.1016/j.biopsych.2018.07.018.

3.

஭ᡭ⪽୍㑻, ụ⏣࿴㝯 (2018) ⸆≀౫Ꮡ. Clinical Neuroscience 36:732-735. ᰝㄞ↓

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 11 ௳㸧
1.

*Ikeda K. GIRK channels and NMDA receptor GluN2D subunit in signal pathways from addictive
substances. FAOPS2019 2019.3.29 ⚄ᡞ

2.

*Ikeda K. Personalized opioid use for overcoming opioid overdose problems.  AsCNPASEAN2019 2019.3.2 Yogyakarta, Indonesia

3.

*ụ⏣࿴㝯 ୰ᯡ⸆ࡢస⏝ᶵᗎゎ᫂ࠊ㛤Ⓨࠊ㐺ṇ౑⏝ࡢࡓࡵࡢ◊✲ᇶ┙㸸JSNP ࡢάືࢆ㋃
ࡲ࠼ࡓ௒ᚋࡢ᪉ྥᛶ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ྜྠᖺ఍ 2018.11.16 ᮾி

4.

*Ikeda K. Tailor-made opioid analgesia based on genome-wide association study. ➨ 15 ᅇᅜ㝿ṑ⛉㯞㓉Ꮫ఍㆟㸦IFDAS2018㸧 2018.10.7 ዉⰋ

5.

*Ikeda K. GIRK channels as common effectors in some pathways of alcohol and other addictive
substances.  19th Congress of International Society for Biomedical Research on Alcoholism－ 82 －

(ISBRA2018) 2018.9.11 ி㒔
6.

*ụ⏣࿴㝯 Ⓨ㐩㞀ᐖ࡜ࣔࣀ࢔࣑ࣥ ➨ 33 ᅇ᪥ᮏ኱⬻ᇶᗏ᰾◊✲఍ 2018.8.25 ᮾி

7.

*ụ⏣࿴㝯ࠊす⃝኱㍜ࠊᯘ⏣┾࿴ࠊ⚟⏣ㅬ୍ 㑇ఏᏊከᆺ࠿ࡽࡳࡓࢸ࣮࣮࣓࣮ࣛࢻ་⒪ ᪥ᮏ࣌࢖ࣥࢡࣜࢽࢵࢡᏛ఍ ➨ 52 ᅇ኱఍ 2018.7.20 ᮾி

8.

*Ikeda K. Neuropsychiatric phenotypes in dopamine-deficient mice and dopamine transporter
knockout mice. 31st CINP World Congress 2018.6.18 Vienna, Austria

9.

*Ikeda K, Ide S. NMDA receptor channel GluN2D subunit as a new target molecule for medicines
for mental disorders. 24th International Union of Biochemistry and Molecular Biology (IUBMB)Congress and 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists(FAOBMB) Congress 2018.6.5 Seoul, Korea

10. *ụ⏣࿴㝯 㑇ఏᏊ㓄ิ࡛ࢃ࠿ࡿ㙠③⸆ឤཷᛶಶேᕪ ➨ 12 ᅇ᪥ᮏ⦆࿴་⒪⸆Ꮫ఍ᖺ఍
2018.5.26 ᮾி
11. *ụ⏣࿴㝯 ⑊③ឤཷᛶ࡜㙠③⸆ឤཷᛶࡢ㑇ఏせᅉゎ᫂࡜ࡑࡢ⮫ᗋᛂ⏝ ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ 2018.5.25 ᮾிࡑࡢ௚ 㸦ィ 33 ௳㸧⮬⏤ᥖ㍕
1.

*Ikeda K. Clinical study of GIRK channel inhibitors as candidate medicines for drug dependence.
➨ 92 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍ 2019.3.14 ኱㜰

2.

*Ochiai Y, Fujita M, Takeda TC, Hagino Y, Kobayashi K, Ikeda K. Analysis of neuronal activity in
hyperlocomotive dopamine-deficient mice.  AsCNP-ASEAN2019  2019.3.2  Yogyakarta,
Indonesia

3.

*Ochiai Y, Fujita M, Ikeda K. Investigation of dopamine-deficient mice showing hyperactivity.
AsCNP-ASEAN2019 2019.3.1 Yogyakarta, Indonesia

4.

*Kasai S, Ikeda K. Transcriptome analyses in rodent models and postmortem human brains.
AsCNP-ASEAN2019 2019.3.1 Yogyakarta, Indonesia

5.

*Ohka S, Nishizawa D, Fukuda K, Ikeda K. Associations between polymorphisms of theinflammation-related genes and analgesia or sensitivity to analgesics.  AsCNP-ASEAN2019
2019.3.1 Yogyakarta, Indonesia

6.

*Nishizawa D, Ikeda K. Identification of genetic variations associated with human sensitivity to
addictive substances and its clinical application. AsCNP-ASEAN2019 2019.3.1 Yogyakarta,
Indonesia7.

*᳃ᒇ⏤⣖ࠊす⃝኱㍜ࠊ஭ᡭ⪽୍㑻ࠊụ⏣࿴㝯 㑇ఏᏊᨵኚ࣐࢘ࢫ࡜౫Ꮡᛶ⸆≀ࢆ⤌ࡳྜࢃࡏࡓ⚄ὠ⸆⌮Ꮫⓗᐇ㦂࡟ࡼࡿ఍᝟ືࡢ࣓࢝ࢽࢬ࣒ゎᯒ ᖹᡂ 30 ᖺᗘᩥ㒊⛉Ꮫ┬᪂Ꮫ⾡㡿ᇦ◊✲ Ꮫ⾡◊✲ᨭ᥼ᇶ┙ᙧᡂ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ᡂᯝⓎ⾲఍
2019.1.31 ⁠㈡┴኱ὠ

8.

*Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino
S, Ikeda K. Rapamycin improves social deficits in the mice treated prenatally with valproi acid.
57th Annual Meeting American College of Neuropsychopharmacology (ACNP 2018) 2018.12.11
Florida, USA9.

*஭ୖ⌮ᜨࠊす⃝኱㍜ࠊ㛗㇂ᕝ‽Ꮚࠊ୰ᒣிᏊࠊ⚟⏣ㅬ୍ࠊᯘ⏣┾࿴ࠊụ⏣࿴㝯 ⭡⭍㙾⿵ຓୗ኱⭠⤖⭠ษ㝖⾡ᚋ㙠③⸆ឤཷᛶࢤࣀ࣒࣡࢖ࢻ⥙⨶ⓗከᆺゎᯒ࡛ୖ఩ೃ⿵࡜࡞ࡗࡓ୍

－ 83 －

ሷᇶከᆺ࡟㛵ࡍࡿእ⛉ⓗ㢡▹ṇ⾡ᚋ㙠③⸆ឤཷᛶ࡜ࡢ㛵㐃 ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾி
10. *኱ᒸ㟼⾰ࠊす⃝኱㍜ࠊ㛗㇂ᕝ‽Ꮚࠊబ⸨┤⨾ࠊᒣ⏣ⱥᏕࠊ㇂ᒸ᭩ᙪࠊ᳥ᮧ᫓ᙪࠊụ⏣࿴㝯
STAT4 㑇ఏᏊࡢ୍ሷᇶከᆺ rs6738544 ࠾ࡼࡧ STAT6 㑇ఏᏊࡢ୍ሷᇶከᆺ rs2298170 ࡣࢽࢥࢳࣥ౫Ꮡ࡜⤫ィⓗ࡟᭷ព࡟㛵㐃ࡍࡿ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾி
11. *஭ᡭ⪽୍㑻ࠊụ❑⤖Ꮚࠊᶫᮏㅬ஧ࠊ୕ရᫀ⨾ࠊụ⏣࿴㝯 NMDA ཷᐜయ GluN2D ࢧࣈࣘࢽࢵࢺḞᦆ࣐࢘ࢫ࡟࠾ࡅࡿ(R)-ࢣࢱ࣑ࣥࡢᣢ⥆ⓗᢠ࠺ࡘຠᯝ࡞ࡽࡧ࡟ㄆ▱ᶵ⬟㜼ᐖຠᯝࡢᾘኻ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍
2018.11.16 ᮾி
12. *⸨⏣㞞௦ࠊⴗ㔝ὒᏊࠊṊ⏣኱ᚿࠊ➟஭ៅஓࠊ㧗ᯇᖾ㞝ࠊụ⏣࿴㝯 ࢻ࣮ࣃ࣑ࣥḞஈ࣐࢘ࢫࢆ⏝࠸ࡓྛ✀⮬Ⓨ⾜ືࡢ࠾ࡅࡿࢻ࣮ࣃ࣑ࣥ౫Ꮡ⑕ࡢゎᯒ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾி
13. *す⃝኱㍜ࠊ㧘ᶫ㤶ኸ㔛ࠊྜྷ⏣㤶⧊ࠊ➟஭ៅஓࠊ㛗㇂ᕝ‽Ꮚࠊ୰ᒣிᏊࠊỤ⏿⿱Ꮚࠊ㧗໭⩏ᙪࠊ⚟⏣ㅬ୍ࠊ୍ᡞ㐩ஓࠊụ⏣࿴㝯 ࢤࣀ࣒࣡࢖ࢻ㛵㐃ゎᯒ(GWAS)࡟ࡼࡿ෭ỈㄏⓎ⑊③
ヨ㦂࡟࠾ࡅࡿࣇ࢙ࣥࢱࢽࣝࡢ㙠③ຠᯝ࡜㛵㐃ࡍࡿ㑇ఏᏊከᆺࡢྠᐃ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾி
14. *ྂ⏣ᓥᾈᏊࠊ㧗㔝Ṍࠊ኱㇂ಖ࿴ࠊሯᮏṇኴ㑻ࠊᮧୖ┿⣖ࠊ⯪⏣኱㍜ࠊ㇂ῲ⏤ᕸᏊࠊ❧᳃ஂ↷ࠊ୸ᑿ࿴ྖࠊబࠎᮌ๛ࠊ㧗ᶫⱥᙪࠊᕝேග⏨ࠊⰼᕝ㝯ࠊᯇᮏಇᙪࠊụ⏣࿴㝯 ぬࡏ࠸๣౫Ꮡ⑕ᝈ⪅⪅࡟࠾ࡅࡿ࢖ࣇ࢙ࣥࣉࣟࢪࣝࡢຠᯝ᳨ウ࡜ fMRI ࢆᇶⅬ࡜ࡋࡓࣂ࢖࣐࣮࣮࢜࢝
ࡢ㛤Ⓨ㸸஧㔜┣᳨↓సⅭ໬ẚ㍑ヨ㦂(◊✲ࣉࣟࢺࢥࣝ) ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.15 ᮾி
15. *㧘ᶫ㤶ኸ㔛ࠊす⃝኱㍜ࠊᒣ⏣ⰾႹࠊ➟஭ៅஓࠊ㡲㔝Ꮫࠊ㧗໭⩏ᙪࠊ୍ᡞ㐩ஓࠊ⚟⏣ㅬ୍ࠊụ⏣࿴㝯 ࣉ࣏ࣟࣇ࢛࣮ࣝᢞ୚ᚋࡢຠᯝ㒊఩⃰ᗘ࡟࠾ࡅࡿ CYP2B6 ࡢ㑇ఏᏊከᆺࡢᙳ㡪.
➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.15ᮾி
16. *బ⸨ᩔᚿࠊụ⏣࿴㝯ࠊỈཱྀ㞞 mTOR 㜼ᐖ๣ࢆ౑⏝୰ࡢ⤖⠇ᛶ◳໬⑕ᝈ⪅࡟࠾ࡅࡿ⮬㛢⑕⑕≧ࡢኚ໬ ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠ
ᖺ఍ 2018.11.15 ᮾி
17. *Nishizawa D, Takahashi K, Yoshida K, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y,
Fukuda K, Ichinohe T, Ikeda K. Genome-wide association study identifies gene polymorphisms
associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test.
The 68th Annual Meeting of the American Society of Human Genetics (ASHG2018) 2018.10.18
San Diego, USA
18. *Sato A, Tanaka M, Kashii H, Kotajima-Murakami H, Kasai S, Hagino Y, Kobayashi T, Hino O,
Mizuguchi M, Ikeda K. Autistic-like behavioral deficits are severer in Tsc2 than Tsc1
haploinsufficiency in mouse models of TSC. ᅜ 㝿 TSC ࣜ ࢧ ࣮ ࢳ ࢝ ࣥ ࣇ ࢓ ࣞ ࣥ ࢫ 2018
(ITSCRC2018) 2018.9.14 ᮾி
19. *Moriya Y, Kasahara Y, Hall FS, Ikeda K, Uhl GR, Sora I. How social deprivation differentiallyaffects alcohol intake behavior among male andfemale mice?. 19th Congress of International

Society for Biomedical Research on Alcoholism (ISBRA2018) 2018.9.12 ி㒔

－ 84 －

20. *Moriya Y, Kasahara Y, Hall FS, Ikeda K, Uhl GR, Sora I. Psychological or physiological stressinduced alcohol consumption in mice lacking opioid receptors. 19th Congress of International
Society for Biomedical Research on Alcoholism (ISBRA2018) 2018.9.12 ி㒔
21. *Nishizawa D, Ikeda K. Identification of genetic polymorphisms associated with human sensitivity
to addictive substances and its clinical application. 19th Congress of International Society for
Biomedical Research on Alcoholism (ISBRA2018) 2018.9.12 ி㒔
22. *Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K. Role of NMDA receptor GluN2D subunit in
the antidepressant effects and the cognitive impairment effects on enantiomers of ketamine. 18th
World Congress of Basic and Clinical Pharmacology (WCP2018) 2018.7.4 ி㒔
23. *Moriya Y, Kasahara Y, Hagino Y, Hall FS, Hen R, Ikeda K, Uhl GR, Sora I. The role of the serotonin
1B receptor system in the development of methamphetamine-induced sensitization. IBNS 27th
Annual Meeting 2018.6.29 Boca Raton Resort, USA
24. *Nishizawa D, Takahashi K, Yoshida K, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y,
Fukuda K, Ichinohe T, Ikeda K. Genome-wide association study identifies genetic polymorphisms
associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test.
31st CINP World Congress 2018.6.19 Vienna, Austria
25. *Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K. The long-lasting antidepressant effects andthe cognitive impairment effects of (R)-ketamine are abolished in NMDA receptor GluN2D subunit
knockout mice. 31st CINP World Congress 2018.6.18 Vienna, Austria
26. *Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino
S, Ikeda K. Rapamycin ameliorates impairment of social interaction in the mice exposed in utero tovalproic acid. 31st CINP World Congress 2018.6.18 Vienna, Austria
27. *Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K. Gene expression profile of dopamine-deficientmouse brain for underlying molecular pathology in psychiatric disorders.  31st CINP World
Congress 2018.6.18 Vienna, Austria
28. *Ohka S, Nishizawa D, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Ikeda K. rs6738544
SNP of STAT4 and rs2298170 SNP of STAT6 associate with nicotine dependence. 31st CINPWorld Congress 2018.6.18 Vienna, Austria
29. *Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H,
Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu
M, Tanaka M, Hayashida M, Sugimura H, Ikeda K. The orexin (hypocretin) receptor 2 gene
polymorphism Val308Ile associated with nicotine dependence. 2018 NIDA International Forum
2018.6.11 San Diego, USA
30. *Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H,
Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu
M, Tanaka M, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin)
receptor 2 gene polymorphism Val308Ile and nicotine dependence found in genome-wide andsubsequent association studies. CPDD 80th Annual Scientific Meeting 2018.6.10 San Diego,USA
31. *᯽஭ὒᩥࠊబ⸨ᩔᚿࠊ➟஭ៅஓࠊⴗ㔝ὒᏊࠊྂ⏣ᓥᾈᏊࠊ⏣୰⨾Ṍࠊᑠᯘᩄஅࠊᵽ㔝⯆ኵࠊụ⏣࿴㝯ࠊᒸ᫂ࠊỈཱྀ㞞 ⤖⠇ᛶ◳໬⑕ࣔࢹ࣐ࣝ࢘ࢫࡢ⮬㛢⑕ᵝ⾜ື࡟㛵ࢃࡿ㑇ఏᏊ－ 85 －

Ⓨ⌧ኚ໬ࡢゎᯒ ➨ 60 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍ 2018.5.31 ༓ⴥ
32. *బ⸨ᩔᚿࠊ⏣୰⨾Ṍࠊ➟஭ៅஓࠊⴗ㔝ὒᏊࠊྂ⏣ᓥᾈᏊࠊ᯽஭ὒᩥࠊす⸨Ὀᫀࠊ✄ᇉ┿⃈ࠊ᭮Ⰻ୍㑻ࠊỈཱྀ㞞ࠊụ⏣࿴㝯 ࢭࣟࢺࢽࣥࢺࣛࣥࢫ࣏࣮ࢱ࣮Ḟᦆ࣐࢘ࢫࡢ⮬㛢⑕ᵝ⾜ືࡣࢺࣜࣉࢺࣇ࢓ࣥḞஈ㣗࡟ࡼࡗ࡚ᨵၿࡍࡿ ➨ 60 ᅇ᪥ᮏᑠඣ⚄⤒Ꮫ఍Ꮫ⾡㞟఍
2018.5.31 ༓ⴥ
33. ụ⏣࿴㝯 ཱྀ⭍㢦㠃㡿ᇦ⚄⤒㞀ᐖᛶ⑊③ࡢ㑇ఏᏊせᅉ◊✲ ៏ᛶࡢ③ࡳデ⒪࣭ᩍ⫱ࡢᇶ┙࡜࡞ࡿࢩࢫࢸ࣒ᵓ⠏࡟㛵ࡍࡿ◊✲⌜ ᖹᡂ 30 ᖺᗘ ➨ 1 ᅇ∵⏣⌜⌜఍㆟ 2018.4.22 ᮾி
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 5 ௳㸧1.

*ụ⏣࿴㝯 ⢭⚄࣭⚄⤒⑌ᝈ἞⒪⸆㛤Ⓨ࡟࠾ࡅࡿ࢔࢝ࢹ࣑࢔ࡢά⏝ [ㅮ₇] ኱᪥ᮏఫ཭〇⸆ᰴᘧ఍♫ ♫ෆㅮ₇఍ 2019.2.4 ኱᪥ᮏఫ཭〇⸆ᰴᘧ఍♫኱㜰◊✲ᡤ ኱㜰2.

*ụ⏣࿴㝯 ౫Ꮡᛶ≀㉁ࡢస⏝ᶵᗎゎᯒ࡜ࡑࡢ་⒪ᛂ⏝ [ㅮ₇] ᫍ⸆⛉኱Ꮫ⸆⌮Ꮫ◊✲ᐊࢭ࣑ࢼ࣮ 2018.12.19 ᫍ⸆⛉኱Ꮫ ᮾி3.

*ụ⏣࿴㝯 ౫Ꮡ⑕ࡢᇶ♏▱㆑ [ㅮ₇] ୡ⏣㇂༊❧ඵᖭᒣᑠᏛᰯ⸆≀஘⏝㜵Ṇㅮ⩦఍
2018.11.29 ඵᖭᒣᑠᏛᰯ ᮾி4.

*ụ⏣࿴㝯 ౫Ꮡᛶ⸆≀ࡢస⏝ᶵᗎゎ᫂࡟ࡼࡿ⬻ᶵ⬟ࡢ⌮ゎ࡜་⒪ᛂ⏝ [ㅮ₇] 㟁Ẽ㏻ಙ኱Ꮫ ⬻⛉Ꮫࣛ࢖ࣇࢧ࣏࣮ࢺ◊✲ࢭࣥࢱ࣮ࢭ࣑ࢼ࣮ 2018.11.1 㟁Ẽ㏻ಙ኱Ꮫ ᮾி5.

*ụ⏣࿴㝯 ᩚᙧእ⛉⑌ᝈ࡟࠾ࡅࡿࢤࣀ࣒᝟ሗࡢ཰㞟࡟ࡘ࠸࡚ [ㅮ₇] ➨ 1 ᅇရᕝᩚᙧእ
⛉ࢤࣀ࣒࣭ࣇ࢛࣮࣒ࣛ 2018.10.26 ✄Ἴ⬨᳝࣭㛵⠇⑓㝔 ᮾி

IV. ≉グ஦㡯࠙≉チࠚ1.

ụ⏣࿴㝯ࠊす⃝኱㍜ࠊ⚟⏣ㅬ୍ ࢧ࢖ࢡࣜࢵࢡ AMP ᛂ⟅㓄ิ⤖ྜࢱࣥࣃࢡ㉁㑇ఏᏊゎᯒ࡟ࡼࡿ⸆≀ឤཷᛶ࠾ࡼࡧ⑌ᝈ⬤ᙅᛶࡢホ౯᪉ἲ. [ᡂ❧] ≉チᗇ, ≉チⓏ㘓➨ 6325254 2018.4.20

࠙⾜ᨻጤဨࠊᩍဨࠚ
1.

ụ⏣࿴㝯㸦2018.12-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ពᛮỴᐃ஦ᴗ ホ౯ጤဨ఍ጤဨ

2.

ụ⏣࿴㝯㸦2018.9-2019.3㸧ᮾி㒔࢔ࣝࢥ࣮ࣝ೺ᗣ㞀ᐖᑐ⟇᥎㐍ィ⏬⟇ᐃጤဨ఍ጤဨ㛗3.

ụ⏣࿴㝯㸦2017.12-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ 㞴἞ᛶ⑌ᝈᐇ⏝໬◊✲஦ᴗ ㄢ㢟ホ౯
ጤဨ఍ጤဨ

4.

ụ⏣࿴㝯㸦2017.4-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ⬻⛉Ꮫ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ⬻⛉Ꮫ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ㸦⼥ྜ⬻㸧ㄢ㢟ホ౯ጤဨ఍ጤဨ

5.

ụ⏣࿴㝯㸦2017.1-⌧ᅾ㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ⸆஦࣭㣗ရ⾨⏕ᑂ㆟఍⮫᫬ጤဨ6.

ụ⏣࿴㝯㸦2017.1-⌧ᅾ㸧ཌ⏕ປാ┬ ་⸆࣭⏕ά⾨⏕ᒁ ┘どᣦᑟ࣭㯞⸆ᑐ⟇ㄢ ౫Ꮡᛶ⸆≀᳨ウ఍ᵓᡂဨ

7.

ụ⏣࿴㝯㸦2016.4-⌧ᅾ㸧᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ⬻࡜ᚰࡢ◊✲ㄢ⼥ྜ⬻஦ᴗࣉࣟࢢ࣒ࣛ࢜ࣇ࢕ࢧ࣮

8.

ụ⏣࿴㝯㸦2014.4-⌧ᅾ㸧᪂₲኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉࣭ᐈဨᩍᤵ

9.

ụ⏣࿴㝯㸦2014.4-⌧ᅾ㸧ᮾி኱Ꮫ་Ꮫ㒊࣭㠀ᖖ໅ㅮᖌ10. ኱ᒸ㟼⾰㸦2016-⌧ᅾ㸧ᩥ㒊⛉Ꮫ┬ 㑇ఏᏊ⤌᥮࠼ᢏ⾡➼ᑓ㛛ጤဨ࠙Ꮫ఍ᙺဨࠚ
1.

ụ⏣࿴㝯㸦2018-⌧ᅾ㸧᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ ᑗ᮶ᵓ᝿ጤဨ

2.

ụ⏣࿴㝯㸦2012-⌧ᅾ㸧᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ ホ㆟ဨ

－ 86 －

3.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⚄⤒⛉Ꮫศ⛉఍ጤဨ

4.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ࢔ࢹ࢕ࢡࢩࣙࣥศ⛉఍ጤဨ5.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⬻࡜ࡇࡇࢁࡢศ⛉఍ጤဨ6.

ụ⏣࿴㝯㸦2015-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ ⬻࡜ࡇࡇࢁࡢศ⛉఍ᖿ஦7.

ụ⏣࿴㝯㸦2014-⌧ᅾ㸧᪥ᮏᏛ⾡఍㆟ 㐃ᦠ఍ဨ8.

ụ⏣࿴㝯㸦2017-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ ホ㆟ဨ

9.

ụ⏣࿴㝯㸦2016-2018㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⌮஦㛗

10. ụ⏣࿴㝯㸦2014-⌧ᅾ㸧᪥ᮏ⚄⤒⛉ᏛᏛ఍ ఍ィ┘஦11. ụ⏣࿴㝯㸦2013-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⌮஦
12. ụ⏣࿴㝯㸦2004-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
13. ụ⏣࿴㝯㸦2012-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ (JMSAAS) 㸦ᪧࢽࢥࢳ࣭ࣥ
⸆≀౫Ꮡ◊✲ࣇ࢛࣮࣒ࣛࠊ᪥ᮏ࢔ࣝࢥ࣮ࣝ⢭⚄་Ꮫ఍ࠊ᪥ᮏ౫Ꮡ⚄⤒⢭⚄⛉Ꮫ఍ࠊ᪥ᮏ࢔
ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㸧 ᗈሗ࣭⦅㞟ጤဨ㛗
14. ụ⏣࿴㝯㸦2008-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ⌮஦
15. ụ⏣࿴㝯㸦2005-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ࢔ࢹ࢕ࢡࢩࣙࣥ་Ꮫ఍ ホ㆟ဨ
16. ụ⏣࿴㝯㸦2012-⌧ᅾ㸧᪥ᮏ⬻⛉Ꮫ㛵㐃Ꮫ఍㐃ྜ ホ㆟ဨ
17. ụ⏣࿴㝯㸦2006-⌧ᅾ㸧㙠③⸆࣭࢜ࣆ࢜࢖ࢻ࣌ࣉࢳࢻ◊✲఍(JNRC) ୡヰே
18. ụ⏣࿴㝯㸦2018-present㸧Neuropsychopharmacology Reports, Associate Editor
19. Ikeda K㸦2017-present㸧International Brain Research Organization (IBRO), CJK ጤဨ
20. Ikeda K㸦2018-present㸧International College of Neuropsychopharmacology (CINP), Treasurer
21. Ikeda K㸦2016-2018㸧International College of Neuropsychopharmacology (CINP), Councillor
22. Ikeda K㸦2014-present㸧International College of Neuropsychopharmacology (CINP), Constitution
Committee Member
23. Ikeda K㸦2017-2018㸧Asian College of Neuropsychopharmacology (AsCNP), President-elect24. Ikeda K㸦2015-2018㸧International Narcotics Research Conference (INRC), Executive Committee
Member
25. ➟஭ៅஓ㸦2016-⌧ᅾ㸧᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍ ホ㆟ဨ
26. ➟஭ៅஓ㸦2012-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
27. ➟஭ៅஓ㸦2016-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ⦅㞟ጤဨ఍ጤဨ
28. ஭ᡭ⪽୍㑻㸦2016-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ
29. ஭ᡭ⪽୍㑻㸦2013-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ ḟୡ௦ࡢ఍ ୡヰே
30. ஭ᡭ⪽୍㑻㸦2017-⌧ᅾ㸧᪥ᮏ⸆⌮Ꮫ఍ Ꮫ⾡ホ㆟ဨ
31. す⃝኱㍜㸦2012-⌧ᅾ㸧᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ホ㆟ဨ࠙Ꮫ⾡㞧ㄅ⦅㞟ࠚ
1.

Ikeda K㸦2018-present㸧Associate Editor㸪Neuropsychopharmacology Reports

2.

Ikeda K㸦2017-present㸧Field Editor㸪Alcoholism: Clinical & Experimental Research3.

Ikeda K㸦2012-present㸧Editorial Advisory Board Member㸪Addiction Genetics

4.

Ikeda K㸦2012-present㸧Associate Editor Board Member㸪Journal of Drug and Alcohol Research5.

Ikeda K㸦2009-present㸧Academic Editor㸪PLoS ONE

6.

Ikeda K㸦2008-present㸧Editorial Advisory Board Member㸪The Open Pain Journal

7.

Ikeda K㸦2008-present㸧Editorial Advisory Board Member㸪The Open Neuropsychopharmacology－ 87 －

Journal
8.

Kasai S㸦2017-present㸧Associated editor㸪Neuropsychopharmacology Reports

9.

Kasai S㸦2016-present㸧Editorial Board Member㸪Pain Research & Management

10. Kasai S㸦2014-present㸧Editorial Board Member㸪Journal of Schizophrenia Research
11. Kasai S㸦2014-present㸧Editorial Board Member㸪Journal of Addiction Medicine & Therapy
12. Nishizawa D㸦2014-present㸧Editorial Board Member㸪Journal of Addiction Medicine & Therapy࠙ࡑࡢ௚ࡢάືࠚ
1.

Ikeda K. YOUNG PSYCHIATRIST AWARD (YPA) PRESENTATION [ᗙ㛗] AsCNP-ASEAN2019
2019.3.2 Yogyakarta, Indonesia

2.

Ikeda K. TMIMS SYMPOSIUM: Identification of Mechanisms Underlying Addiction andDevelopment of Novel Treatments (Symposium sponsored by Tokyo Metropolitan Institute ofMedical Science) [ᗙ㛗] AsCNP-ASEAN2019 2019.3.1 Yogyakarta, Indonesia

3.

Ikeda K. WELCOME LECTURE 02: Neuroimaging Advances for Depression: Toward Innovative
Diagnosis and Treatment [ᗙ㛗] AsCNP-ASEAN2019 2019.2.28 Yogyakarta, Indonesia

4.

ụ⏣࿴㝯 ⏕⌮ᶵ⬟ゎᯒᡂᯝ࣮࣡ࢡࢩࣙࢵࣉ 1㸸ࢥࣥࢻࣟ࢖ࢳࣥ◲㓟ྜᡂ㓝⣲ࡢࣀࢵࢡ࢔
࢘ࢺ࣐࢘ࢫゎᯒ [ᗙ㛗] ᖹᡂ 30 ᖺᗘ᪂Ꮫ⾡㡿ᇦ◊✲ Ꮫ⾡◊✲ᨭ᥼ᇶ┙ᙧᡂ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ᡂᯝⓎ⾲఍ 2019.1.30 ⍇⍈†࣍ࢸࣝ ኱ὠ5.

ụ⏣࿴㝯 ⏕⌮ᶵ⬟ゎᯒᡂᯝ࣮࣡ࢡࢩࣙࢵࣉ 2㸸⬻ࡢⓎ⏕Ⓨ㐩࡜ᶵ⬟࡟࠾ࡅࡿ DNA ࣏࣓࣮ࣜࣛࢮ beta ࡢᙺ๭ [ᗙ㛗] ᖹᡂ 30 ᖺᗘ᪂Ꮫ⾡㡿ᇦ◊✲ Ꮫ⾡◊✲ᨭ᥼ᇶ┙ᙧᡂ ඛ➃ࣔࢹࣝື≀ᨭ᥼ࣉࣛࢵࢺࣇ࢛࣮࣒ᡂᯝⓎ⾲఍ 2019.1.30 ⍇⍈†࣍ࢸࣝ ኱ὠ6.

ụ⏣࿴㝯 ࢩ࣏ࣥࢪ࣒࢘ 20㸸࣮࢜ࣉࣥࢧ࢖࢚ࣥࢫ᫬௦ࡢᏛ఍ㄅ㸸ࡇࢀ࠿ࡽࡢᡂᯝⓎಙ࡜ࡑࡢホ౯ࡢ࠶ࡾ᪉ [ᗙ㛗] ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾிࢻ࣮࣒࣍ࢸࣝ ᮾி7.

ụ⏣࿴㝯 ࢩ࣏ࣥࢪ࣒࢘ 15㸸⢭⚄་Ꮫࡢ௒ᚋࡢ◊✲ࡢ᪉ྥᛶ [ᗙ㛗] ➨ 28 ᅇ᪥ᮏ⮫ᗋ⢭⚄⚄⤒⸆⌮Ꮫ఍࣭➨ 48 ᅇ᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ ྜྠᖺ఍ 2018.11.16 ᮾிࢻ࣮࣒࣍ࢸ
ࣝ ᮾி

8.

Ikeda K. Symposium 31: Common and Different Mechanisms Underlying Dependence on Alcoholand Other Addictive Substances [ᗙ㛗] 19th Congress of International Society for Biomedical
Research on Alcoholism (ISBRA2018) 2018.9.11 ᅜ❧ி㒔ᅜ㝿఍㤋 ி㒔9.

ụ⏣࿴㝯 ⌮஦㛗௻⏬ࢩ࣏ࣥࢪ࣒࢘㸸ḟୡ௦ࡢ࢔ࢹ࢕ࢡࢩࣙࣥ◊✲ࢆࡵࡊࡋ࡚ [ᗙ㛗] ᖹᡂ 30ᖺᗘ࢔ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍ 2018.9.10 ᅜ❧ி㒔ᅜ㝿఍㤋 ி㒔

10. ụ⏣࿴㝯 ᪥ᮏ⚄⤒⛉ᏛᏛ఍࣭᪥ᮏ⚄⤒⢭⚄⸆⌮Ꮫ఍ྜྠࢩ࣏ࣥࢪ࣒࢘㸸Ⓨ㐩㞀ᐖࡣࡇࡇࡲ࡛ࢃ࠿ࡗࡓ㸫ศᏊࣞ࣋ࣝ࠿ࡽ⮫ᗋࡲ࡛㸫 [ᗙ㛗] ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2018.7.28
⚄ᡞࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮ ⚄ᡞ
11. Ikeda K. SYMPOSIA19: Dopamine signal intensity in neuropsychiatric disorders: etiology andtherapy [ᗙ㛗] 31st CINP World Congress 2018.6.18 Vienna, Austria－ 88 －

ࣉࣟࢪ࢙ࢡࢺྡ

࢝ࣝࣃ࢖ࣥࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 0 ௳㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

Lostal W, 㸦௚ 12 ྡ㸧, Ono Y, 㸦௚ 7 ྡ㸧, Walter, M 㸦2018㸧 233rd ENMC International
Workshop:: Clinical Trial Readiness for Calpainopathies, Naarden, The Netherlands, 15-17
September 2017. Neuromusc Disord, 28, 540-549.㸦ᰝㄞ↓㸧

2.

⛙຾ᚿࠊᑠ㔝ᘺᏊ 㸦2018㸧 ࠕ࢝ࣝࣃ࢖ࣥࣇ࢓࣑࣮ࣜࡣಶᛶὴᥞ࠸ࠖ་Ꮫࡢ࠶ࡺࡳ 267
㸦13㸧, 1003-1008. 㸦ᰝㄞ↓㸧3.
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 9 ௳㸧⮬⏤ᥖ㍕
1.

⛙຾ᚿ ࢝ࣝࣃ࢖ࣥࡢไᚚ␗ᖖࡣ஝ⓄⓎ⑕࡟㛵୚ࡍࡿ ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2019 ᖺᗘ኱఍
2019.3.24㹼3.27 ᮾி㒔

2.

኱ෆྐᏊ ࢝ࣝࣃ࢖ࣥ 1 ࡢไᚚᅉᏊ࡜ࡋ࡚ࡢ࢝ࣝࣃ࢖ࣥ 2 ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2019 ᖺᗘ኱఍ 2019.3.24㹼3.27 ᮾி㒔

3.

㔝ཱྀ࠶ࡸ ࣘࣅ࢟ࢳࣥ࡜⤖ྜࡍࡿ࢝ࣝࣃ࢖ࣥ 15 ࡢᶵ⬟ゎᯒ ➨ 1 ᅇ᪂Ꮫ⾡ࢣࣔࣘࣅ࢟ࢳ
ࣥ㡿ᇦ⌜఍㆟࣭➨ 2 ᅇࣘࣅ࢟ࢳࣥ◊✲఍ྜྠ఍㆟ 2019.1.14㹼1.16 ᮾி㒔4.

⛙຾ᚿ ࣘࣅ࢟ࢳࣥ࡜⤖ྜࡍࡿ᪂ወ࢝ࣝࣃ࢖ࣥࡢྠᐃ ➨ 1 ᅇ᪂Ꮫ⾡ࢣࣔࣘࣅ࢟ࢳࣥ㡿ᇦ⌜఍㆟࣭➨ 2 ᅇࣘࣅ࢟ࢳࣥ◊✲఍ྜྠ఍㆟ 2019.1.14㹼1.16 ᮾி㒔

5.

Koichi Ojima, Yasuko Ono, Shoji Hata, Fumiko Shinkai-Ouchi, Mika Oe, Susumu Muroya,Hiroyuki Sorimachi.
“Detecting protease activity of muscle specific calpain-3 (CAPN3) in living cells.”
2018 ASCB/EMBO Annual Meeting (USA) 2018.12.11 ࢧࣥࢹ࢕࢚ࢦ㸦⡿ᅜ㸧6.

኱ෆྐᏊࠊఀ⸨⩏ᇛࠊ⛙຾ᚿࠊ㐍⸨┿⏤⨾ࠊᅵ஭ዉ✑Ꮚࠊ཯⏫ὒஅࠊᑠ㔝ᘺᏊ ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕࣮2A ᆺࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ➽⥺⥔ࡢᡂ⇍㐜⁫ ᪥ᮏ➽Ꮫ఍➨ 4 ᅇᏛ⾡㞟
఍ 2018.8.10 ᒸᒣ┴಴ᩜᕷ

7.

኱ෆྐᏊࠊ㐍⸨┿⏤⨾ࠊ⛙຾ᚿࠊ཯⏫ὒஅࠊᑠ㔝ᘺᏊ ࢝ࣝࣃ࢖ࣥí㸰࡟ࡼࡿ࢝ࣝࣃ࢖ࣥ

－ 89 －

㸫㸯ࡢάᛶㄪ⠇ ᪥ᮏ⑓ែࣉࣟࢸ࢔࣮ࢮᏛ఍➨ 23 ᅇ኱఍ 2018.8.3 ᒣ᲍┴⏥ᗓᕷ
8.

ᑠ㔝ᘺᏊࠊ㐍⸨┿⏤⨾ࠊᅵ஭ዉ✑Ꮚࠊ཯⏫ὒஅ ༢୍ࡢ࢝ࣝࣃ࢖ࣥ 10"cDNA"ࡼࡾⓎ⌧ࡉࢀࡿ⏘≀ከᵝᛶ࡟ࡘ࠸࡚ࡢゎᯒ ᪥ᮏ⑓ែࣉࣟࢸ࢔࣮ࢮᏛ఍➨ 23 ᅇ኱఍ 2018.8.3 ᒣ᲍
┴⏥ᗓᕷ

9.

⛙຾ᚿ ஝ⓄⓎ⑕࡟࠾ࡅࡿ࢝ࣝࣃ࢖ࣥࡢ㛵୚࡜ࡑࡢᶵ⬟ゎᯒ ➨ 31 ᅇࣔࣟࢩࢾࢫ◊✲఍
2018.6.23 ໭ᾏ㐨ᮐᖠᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧
1.

ᑠ㔝ᘺᏊ ࢡ࢖࣮ࣥࢬ኱Ꮫ Ꮫ㒊ࢭ࣑ࢼ࣮ 2018.10.18 ࢟ࣥࢢࢫࢺࣥ㸦࢝ࢼࢲ㸧

2.

ᑠ㔝ᘺᏊ ࢝ࣝࣃ࢖ࣀࣃࢳ࣮㸦LGMD2A㸧 ➽ࢪࢫࢺࣟࣇ࢕࣮ࡢᶆ‽ⓗ་⒪ᬑཬࡢࡓࡵࡢ
ㄪᰝ◊✲⌜ බ㛤ࢭ࣑ࢼ࣮ࠕ⫥ᖏᆺ➽ࢪࢫࢺࣟࣇ࢕࣮ Up to Dateࠖ 2018.9.29 ኱㜰ᗓ3.

⛙຾ᚿ ஝ⓄⓎ⑕࡟࠾ࡅࡿ࢝ࣝࣃ࢖ࣥࡢ㛵୚࡜ࡑࡢᶵ⬟ゎᯒ ᮾிࣂ࢖࣐࣮࣮࣭࢜࢝࢖ࣀ
࣮࣋ࢩࣙࣥᢏ⾡◊✲⤌ྜ ➨ 7 ᅇ TOBIRA ◊✲஺ὶࣇ࢛࣮࣒ࣛ 2018.5.11 ᮾி㒔

4.

ᑠ㔝ᘺᏊ ࠕࡓࢇࡥࡃ㉁ࢆ࣐ࢫࢱ࣮ࡋ࡚೺ᗣ࡞య࡟࡞ࢁ࠺ࠖ㒔་Ꮫ◊㒔Ẹㅮᗙᖹᡂ 30 ᖺᗘ➨ 1 ᅇ 2018.4.27 ᮾி㒔IV. ≉グ஦㡯㸦ィ 6 ௳㸧࠙ᩍ⫱άືࡑࡢ௚ࠚ
1.

ᑠ㔝ᘺᏊ Journal of General Physiology Editorial Advisory Board 2019.1.1㹼⌧ᅾ2.

ᑠ㔝ᘺᏊ ࢡ࢖࣮ࣥࢬ኱Ꮫ Ꮫእヨ㦂ᐁ 2018.10.18㹼10.19 ࢟ࣥࢢࢫࢺࣥ㸦࢝ࢼࢲ㸧

3.
4.
5.

ᑠ㔝ᘺᏊ ⟃Ἴ኱Ꮫ኱Ꮫ㝔ࠊ࠾ⲔࡢỈዪᏊ኱Ꮫ኱Ꮫ㝔 㐃ᦠᩍဨ 2018.6㹼⌧ᅾᑠ㔝ᘺᏊ ື≀⏝⤌ࡳ᥮࠼ DNA ᢏ⾡ᛂ⏝་⸆ရㄪᰝ఍ ⸆஦࣭㣗ရ⾨⏕ᑂ㆟఍ᑓ㛛ጤဨࠊ
2017.4㹼⌧ᅾᑠ㔝ᘺᏊ ᅜ㝿⏕≀Ꮫ࢜ࣜࣥࣆࢵࢡ᪥ᮏጤဨ఍㐠Ⴀጤဨ࣭స㢟ጤဨ 2016.4㹼⌧ᅾ

6.

ᑠ㔝ᘺᏊ ⡿࣭࢔ࣜࢰࢼ኱Ꮫ⣽⬊ศᏊ་Ꮫ◊✲⛉ᐈဨ≉௵ㅮᖌ 2011.9㹼⌧ᅾ－ 90 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࣘࣅ࢟ࢳࣥࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

*Yamano, K., Wang, C., Sarraf, S., Münch, C., Kikuchi, R., Noda, N., Hizukuri, Y., Kanemaki, M.,
Harper, W., Tanaka, K., *Matsuda, N., and *Youle R. (2018) Endosomal Rab cycles regulate Parkinmediated mitophagy. eLife, 7: e31326. *: co-correspondence author

2.

Tashiro, S., Caaveiro, J., Nakakido, M., Tanabe, A., Nagatoishi, S., Tamura, Y., Matsuda, N., Liu,
D., Hoang, Q., and Tsumoto, K. (2018) Discovery and optimization of inhibitors of the Parkinson’s
disease associated protein DJ-1. ACS Chemical Biology, 13: 2783-2793.

3.

Yamaguchi, A., Ishikawa, H., Furuoka, M., Yokozeki, M., Matsuda, N., Tanimura S., and Takeda K.
(2018) Cleaved PGAM5 is released from mitochondria depending on proteasome-dependent ruptureof the outer mitochondrial membrane during mitophagy. J. Biochemistry, 165: 19-25.

4.

Okatsu, K., Sato, Y., Yamano, K., Matsuda, N., Negishi, L., Takahashi, A., Yamagata, A., Goto-Ito,S., Mishima, M., Ito, Y., Oka, T., Tanaka K., and Fukai, S. (2018) Structural insights into ubiquitin
phosphorylation by PINK1. Scientific Reports, 8: e10382.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 6 ௳㸧
1.

Yoshida, Y. and Tanaka, K. Cytosolic N-glycans: triggers for ubiquitination directing proteasomal
and autophagic degradation. Bioessays. 40: e1700215 (2018).

2.

ᯇ⏣᠇அࠊᒣ㔝᫭ྐ㸸࣐࢖ࢺࣇ࢓ࢪ࣮㸸PINK1 ࡜ Parkin ࡟ࡼࡿ࣑ࢺࢥࣥࢻࣜ࢔⺮ⓑ㉁ࡢရ
㉁⟶⌮ࠊ་Ꮫࡢ࠶ࡺࡳ㸪་ṑ⸆ฟ∧ 267 ᕳ 13 ྕ㸪in press (2018)3.

ᯇ⏣᠇அ㸸≉㞟 ࢱࣥࣃࢡ㉁᰾㓟ࡢศᏊಟ㣭㸸ࣘࣅ࢟ࢳࣥࣜࣥ㓟໬ࠊ⏕యࡢ⛉Ꮫࠊ་Ꮫ᭩
㝔ࠊVol. 69, No. 5, pp456-457 (2018)4.

ᯇ⏣᠇அ㸸ࣃ࣮࢟ࣥࢯࣥ⑓ࡢ⑓ᅉ 2-3-1㸸ࢱࣥࣃࢡ㉁࣭࢜ࣝ࢞ࢿ࣭ࣛ࢔ࣝࢹࣄࢻศゎ⣔ࠊ᪥ᮏ⮫ᗋࠊ᪥ᮏ⮫∠♫ࠊVol. 76, No. 4, pp156-161 (2018)5.

Yamano, K. and Lazarou, M. YoungMito 2018: Report on the 1st International Mitochondria
Meeting for Young Scientists. Genes Cells. 23: 822-827 (2018)6.

ᑠ㇂㔝ྐ㤶ࠊᯇ⏣᠇அ㸸ࣃ࣮࢟ࣥࢯࣥ⑓ࡢ᪂ᒎ㛤̿Ⓨ⑕ࡢศᏊᶵᵓ࡜᪂つ἞⒪㸸ࣜࣥ㓟໬ࣘࣅ࢟ࢳࣥࢆᇶ㍈࡜ࡋࡓ PINK1 ࡜ Parkin ࡟ࡼࡿ୙Ⰻ࣑ࢺࢥࣥࢻࣜ࢔ࡢ᤼㝖ᶵᵓࠊู෉࣭

་Ꮫࡢ࠶ࡺࡳࠊ་ṑ⸆ฟ∧ࠊISSN 0039-2359: IGAYAY (2018)
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

ᒣ㔝᫭ྐ: ᦆയ࣑ࢺࢥࣥࢻࣜ࢔㑅ᢥⓗศゎࡢ◊✲. ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2018 ᖺᗘ⏕໬Ꮫ఍ዡບ㈹࣭ཷ㈹ㅮ₇ 2018.9.24 ᅜ❧ி㒔ᅜ㝿఍㤋 ி㒔ᗓ

－ 91 －

2.

Matsuda. N.: Mitochondria quality control elucidated from Parkinson's disease, Keystone Symposia,
joint symposium of Mitochondrial Biology (Z1) and Selective Autophagy (Z2),2018.4.22㹼4.26

Westin Miyako Kyoto, Kyoto, Japanࡑࡢ௚ 㸦ィ 8 ௳㸧⮬⏤ᥖ㍕
1.

ᒣ㔝᫭ྐ Mitochondrial Degradation : Dance with Ubiquitin and Autophagy AUS-Osaka Mito
2019

2.

2019.3.26. Australia,Melbourneᯇ⏣᠇அ ⏕໬Ꮫ࣭⣽⬊࣭ᵓ㐀ࡢどⅬ࠿ࡽぢࡓ PINK1 ࡜ Parkin ࡟ࡼࡿ࣑ࢺࢥࣥࢻࣜ࢔ရ
㉁⟶⌮ ➨ 18 ᅇ᪥ᮏ࣑ࢺࢥࣥࢻࣜ࢔Ꮫ఍ᖺ఍ 2018.12.7㹼12.9 ஂ␃⡿኱Ꮫ᪫⏫࢟ࣕࣥࣃࢫ ⚟ᒸ┴ஂ␃⡿ᕷ

3.

ᯇ⏣᠇அ ึᚰ࡟㏉ࡗ࡚ PINK1/ Parkin ࡜࣐࢖ࢺࣇ࢓ࢪ࣮ࡢゎᯒ ➨ 11 ᅇ࣮࢜ࢺࣇ࢓ࢪ࣮
◊✲఍ 2018.11.18㹼11.21 ࡘࡲᜊࣜࢰ࣮ࢺᙬࡢ㒓 㟼ᒸ┴᥃ᕝᕷ

4.

ᒣ㔝᫭ྐ ࣐࢖ࢺࣇ࢓ࢪ࣮࡟࠾ࡅࡿ ZFYVE27 ࡢᙺ๭ ➨ 11 ᅇ࣮࢜ࢺࣇ࢓ࢪ࣮◊✲఍
2018.11.18㹼11.21 ࡘࡲᜊࣜࢰ࣮ࢺᙬࡢ㒓 㟼ᒸ┴᥃ᕝᕷ

5.

ᒣ㔝᫭ྐ Parkin-mediated mitophagy : overview from recent progression, 2018 ᖺᗘ࢜ࣝ࢞
ࢿࣛ◊✲఍ 2018.9.20㹼9.22 㭯ᒸᕷඛ➃ᢏ⾡◊✲⏘ᴗᨭ᥼ࢭࣥࢱ࣮ ᒣᙧ┴㭯ᒸᕷ

6.

ᑠ㇂㔝ྐ㤶 Characterization of Parkin substrate specificity during mitophagy, 8th Proteasome &Autophagy Congress, 2018.4.25㹼4.27 France,Clermont-Ferrand7.

ᯇ ⏣ ᠇ அ  Parkinson's disease-related DJ-1 protects CoA against aldehyde attack in vitro,Young Mito 2018㸦➨ 1 ᅇⱝᡭ࣑ࢺࢥࣥࢻࣜ࢔ᅜ㝿఍㆟㸧 2018.4.19㹼4.22 ி㒔ᗓ8.

ᑠ㇂㔝ྐ㤶 Parkin with low substrate specificity facilitates labeling of damaged mitochondria forelimination,Young Mito 2018㸦➨ 1 ᅇⱝᡭ࣑ࢺࢥࣥࢻࣜ࢔ᅜ㝿఍㆟㸧 2018.4.19㹼4.22

ி㒔ᗓ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯1.

ᒣ㔝᫭ྐ: 2018.4.20㹼4.22 ࡟ி㒔࡛➨ 1 ᅇⱝᡭ࣑ࢺࢥࣥࢻࣜ࢔ᅜ㝿఍㆟㸦The 1st international
YoungMito 2018㸧ࢆ୺ദࠋཧຍ⪅㸸ᅜෆ 67 ྡ࣭ᅜእ 73 ྡ㸦ィ 130 ྡ㸧2.

ᒣ㔝᫭ྐ: 2018 ᖺᗘ ᪥ᮏ⏕໬Ꮫ఍ዡບ㈹ࢆཷ㈹ 2018.9.24－ 92 －

ࣉࣟࢪ࢙ࢡࢺྡ

ᖿ⣽⬊ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

H. Tabata, *T. Hara, and *K. Kitajima. Inhibitory action of an ERK1/2 inhibitor on primitive
endoderm cell differentiation from mouse embryonic stem cells. Biochem. Biophys. Res. Commun.,
512: 399-404, 2019. *Co-corresponding authors.

2.

N. Yokote, M. Y. Suzuki-Kosaka, T. Michiue, *T. Hara, and *K. Tanegashima. Latrophilin2 isinvolved in neural crest cell migration and placode patterning in Xenopus laevis. Int. J. Dev. Biol.,
63: 29-35, 2019. *Co-corresponding authors.

3.

K. Kitajima, M. Kanokoda, M. Nakajima, and T. Hara. Domain-specific biological functions of thetranscription factor Gata2 on hematopoietic differentiation of mouse embryonic stem cells. Genes
Cells, 23: 753-766, 2018.

4.

K. Tanaka, N. Ikeda, K. Miyashita, H. Nuriya, and T. Hara. DEAD box protein DDX1 promotes
colorectal tumorigenesis through transcriptional activation of the LGR5 gene. Cancer Sci., 109:2479-2489, 2018.

5.

K. Miyashita, K. Kitajima, S. Goyama, T. Kitamura, and T. Hara. Overexpression of Lhx2 suppresses
proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2
protein levels. Biochem. Biophys. Res. Commun., 495: 2310-2316, 2018.

6.

N. Uno, T. Fujimoto, S. Komoto, G. Kurosawa, M. Sawa, T. Suzuki, Y. Kazuki, and M. Oshimura.
A luciferase complementation assay system using transferable mouse artificial chromosomes tomonitor protein-protein interactions mediated by G protein-coupled receptors. Cytotechnol., 70:
1499-1508, 2018.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 13 ௳㸧⮬⏤ᥖ㍕
1.

ྜྷ⏣༓⣫ࠊ㖊࿅ెྐࠊᮾᬛஓࠊඵᮌᣅဢࠊ୰⏣༓ᑜࠊṊᬛ࠶࡙ࡉࠊཎᏕᙪࠊ∾ᫀḟ㑻. ᛴ
ᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚไࡍࡿ໬ྜ≀ࡢ㛤Ⓨ. ᪥ᮏ㎰ⱁ໬Ꮫ఍
2019 ᖺᗘ኱఍, 2019.3.24ࠥ3.27 ᮾி㒔ୡ⏣㇂༊

－ 93 －

2.

ᮾᬛஓࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊඵᮌᣅဢࠊ୰⏣༓ᑜࠊṊᬛ࠶࡙ࡉࠊཎᏕᙪࠊ∾ᫀḟ㑻. ᛴ
ᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆᢚไࡍࡿ໬ྜ≀ࡢάᛶ࡟ᚲ㡲࡞໬Ꮫᵓ㐀ࡢⓎぢ. ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2019 ᖺᗘ኱఍.

3.

2019.3.24ࠥ27, ᮾி㒔ୡ⏣㇂༊

T. Hara. Multiple functions of CXCL14 in the CpG DNA transport into dendritic cells/macrophages
for modulating Toll-like receptor 9 signaling. ➨ 47 ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍, 2018.12.10㹼
12.12, ⚟ᒸ┴⚟ᒸᕷ

4.

໭ᓥ೺஧ࠊཎᏕᙪ. ㌿෗ᅉᏊ Gata2 ࡢ㉥⾑⌫ᕧ᰾⌫ㄏᑟࢻ࣓࢖ࣥࡢྠᐃ. ➨ 41 ᅇ᪥ᮏศᏊ
⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ

5.

㕥ᮌ㍤ᙪࠊཎᏕᙪ. DDX1 ࡢḞᦆࡣ p53 ⤒㊰ࢆ௓ࡋ࡚࣐࢘ࢫ⬇ᛶᖿ⣽⬊ࡢቑṪࢆᢚไࡍࡿ.
➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ

6.

⏣⏿㝧⨾ࠊ໭ᓥ೺஧ࠊཎᏕᙪ. ㌿෗ᅉᏊ Gata4 ࡟ࡼࡿ࣐࢘ࢫ ES ⣽⬊࠿ࡽཎጞෆ⬇ⴥ⣔⣽⬊࡬ࡢศ໬ㄏᑟ࣓࢝ࢽࢬ࣒. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ7.

୕஭㈗ὒࠊ✀Ꮚᓥᖾ♸ࠊᡂ℩බேࠊ㔜Ọ❶ࠊ኱㧘❶ࠊཎᏕᙪ. CpG DNA/CXCL14 」ྜయ࡟ᑐࡍࡿೃ⿵ཷᐜయࡢⓎ⌧ࢡ࣮ࣟࢽࣥࢢ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30,⚄ዉᕝ┴ᶓ὾ᕷ

8.

ᒾ℩⍵ዉࠊᡂ℩බேࠊ✀Ꮚᓥᖾ♸ࠊ㔜Ọ❶ࠊ኱㧘❶ࠊཎᏕᙪ. CXCL14 ࡜ CpG DNA ࡢ┦஫స⏝࡟ࡼࡿ TLR9 άᛶ໬ࡢ≉␗ᛶ࡜㈐௵㡿ᇦࡢゎᯒ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍,2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ

9.

ඵᮌᣅဢࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊす⸨ὈᫀࠊṊᬛ࠶࡙ࡉࠊᐑୗ࿴ஓࠊ∾ᫀḟ㑻ࠊཎᏕᙪᛴ
ᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚ࠼ࡿ໬ྜ≀ࡢᶆⓗศᏊ᥈⣴. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ

10. 㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊᐑୗ࿴ஓࠊඵᮌᣅဢࠊṊᬛ࠶࡙ࡉࠊཎᏕᙪࠊ∾ᫀḟ㑻ᛴᛶ T ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚ࠼ࡿపศᏊ໬ྜ≀ࡢ๰ฟ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ
11. ྜྷ⏣༓⣫ࠊṊᬛ࠶࡙ࡉࠊ㖊࿅ెྐࠊඵᮌᣅဢࠊཎᏕᙪࠊ∾ᫀḟ㑻ᛴᛶ㉥ⓑ⾑⑓⣽⬊ࡢቑṪࢆᢚไࡍࡿపศᏊ໬ྜ≀ࡢ๰ฟ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍. 2018.11.28㹼11.30, ⚄ዉᕝ┴ᶓ὾ᕷ
12. Ṋᬛ࠶࡙ࡉࠊ኱἟ᗣᖹࠊ✀Ꮚᓥᖾ♸ࠊ┦ᇉᩄ㑻ࠊす⸨ὈᫀࠊཎᏕᙪ. ᑑ࿨Ṛ┤๓ࡢࢩࣙ࢘
ࢪࣙ࢘ࣂ࢚࡛Ⓨ⌧ኚືࡍࡿ㑇ఏᏊ⩌ࡢྠᐃ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍, 2018.11.28㹼
11.30, ⚄ዉᕝ┴ᶓ὾ᕷ
13. ๓⏣᱈Ꮚࠊ㙊⏣⤮㔛Ꮚࠊ໭ᓥ೺஧ࠊཎᏕᙪࠊబ⸨㤶ᯞ. ఙᒎ่⃭㈇Ⲵࢹࣂ࢖ࢫ࡛ᇵ㣴ࡋࡓ㦵㧊⏤᮶㛫㉁⣽⬊ࡢศἪࡍࡿࢧ࢖ࢺ࢝࢖ࣥࡢศᯒ. ໬Ꮫ࡜࣐࢖ࢡࣟࢼࣀࢩࢫࢸ࣒Ꮫ఍➨37 ᅇ◊✲఍, 2018.5.21ࠥ22, Ⲉᇛ┴ࡘࡃࡤᕷ
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 3 ௳㸧
1.

ཎᏕᙪ ୰ኸ኱Ꮫ⌮ᕤᏛ㒊 ㅮ⩏㸦඲ 15 ᅇ㸧. 2018.4.12~8.26, ᮾி㒔ᩥி༊

2.

ཎᏕᙪ 㤳㒔኱Ꮫᮾி኱Ꮫ㝔 ⏕࿨⛉Ꮫ≉ูㅮ⩏. 2018.8.1, ᮾி㒔ඵ⋤Ꮚᕷ

3.

ཎᏕᙪ ➨ 5 ᅇ㒔Ẹㅮᗙࠕⓑ⾑⑓἞⒪ἲࡢ᭱๓⥺ࠖ࡟࡚ㅮ₇. 2018.10.25, ᮾி㒔༓௦⏣༊

－ 94 －

IV. ≉グ஦㡯࠙≉チฟ㢪ࠚ
3.

ཎᏕᙪࠊᐑୗ࿴ஓࠊඵᮌᣅဢࠊṊᬛ࠶࡙ࡉࠊ∾ᫀḟ㑻ࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫. ≉チฟ㢪ࠕⓑ⾑⑓἞⒪⏝་⸆⤌ᡂ≀ࠖ㸦2018.5.8 ฟ㢪␒ྕ 2018-90192㸧

࠙ࡑࡢ௚ࠚ
1.

ཎᏕᙪ ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔࣭་ṑᏛ⥲ྜ◊✲⛉ 㐃ᦠᩍᤵ㸦ศ㔝㛗㸧
㸦2012 ᖺ 11 ᭶ࠥ⌧ᅾ㸧2.

ཎᏕᙪ 㤳㒔኱Ꮫᮾி኱Ꮫ㝔࣭⌮Ꮫ◊✲⛉⏕࿨⛉Ꮫᑓᨷᐈဨᩍᤵ㸦2017 ᖺ 4 ᭶ࠥ⌧ᅾ㸧

3.

ཎᏕᙪ ᮾி㒔໭༊ࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࢫࢡ࣮ࣝ. 2018.7.24, ᮾி㒔ୡ⏣㇂༊

4.

ཎᏕᙪ ᮾி㒔❧᪥ẚ㇂㧗➼Ꮫᰯ ฟ๓ⱥㄒㅮ⩏. 2018.7.25, ᮾி㒔༓௦⏣༊

5.

ཎᏕᙪ Ⲉᇛ┴❧୪ᮌ୰➼ᩍ⫱Ꮫᰯ ฟ๓ㅮ⩏࡜ᐇ⩦. 2018.10.20, Ⲉᇛ┴ࡘࡃࡤᕷ6.

ཎᏕᙪ 㤶ᕝ┴❧ほ㡢ᑎ➨୍㧗➼Ꮫᰯ ᮾி◊ಟ. 2018.12.6, ᮾி㒔ୡ⏣㇂༊

7.

ཎᏕᙪ Ⲉᇛ┴❧୪ᮌ୰➼ᩍ⫱Ꮫᰯ ◊✲ᡤぢᏛ. 2018.12.16, ᮾி㒔ୡ⏣㇂༊

－ 95 －

ࣉࣟࢪ࢙ࢡࢺྡ

෌⏕་⒪ࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 5 ௳㸧
1.

Ogawa Y, Terao M, Hara S, Tamano M, Okayasu H, Kato T, Takada S. Mapping of a responsible
region for sex reversal upstream of Sox9 by production of mice with serial deletion in a genomic
locus. Scientific Reports 8:17514, 2018.㸦ᰝㄞ᭷㸧

2.

Kato-Inui T, Takahashi G, Hsu S, Miyaoka Y. Clustered regularly interspaced short palindromic
repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homologydirected repair. Nucleic Acids Research 46:4677-4688, 2018㸦ᰝㄞ᭷㸧

3.

Tsuji-Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, Lavery R, Coschiera
A, Schlessinger D, Harley VR, Takada S, Morio T. Peptidyl arginine deiminase 2 (Padi2) isexpressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.
Scientific Reports 8:13263, 2018㸦ᰝㄞ᭷㸧

4.

Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S. A tandem repeat array in
IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonicdevelopment. Human Molecular Genetics 27:3283-3292, 2018㸦ᰝㄞ᭷㸧

5.

Wada K, Saito J, Yamaguchi M, Seki Y, Furugori M, Takahashi G, Nishito Y, Matsuda H, Shitara H,
Kikkawa Y. Pde6brd1 mutation modifies cataractogenesis in Foxe3rct mice. Biochemical andBiophysical Research Communications 496:231-237, 2018㸦ᰝㄞ᭷㸧ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

ᐑᒸభ୍㑻㸸୍ሷᇶ⨨᥮࡟ࡼࡿ⑌ᝈࣔࢹࣝ⣽⬊స〇 ᭶หࠕ⣽⬊ࠖ2019 ᖺ 3 ᭶ྕ㸦ᰝㄞ࡞ࡋ㸧

2.

Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR. Detection and Quantification of HDR and NHEJ
induced by genome editing at endogenous gene loci using Droplet Digital PCR. Methods in
Molecular Biology 1768:349-362, 2018㸦ᰝㄞ᭷㸧II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

ຍ⸨-஝᭸Ꮚࠊ㧗ᶫ๛ࠊチ⤬ⲓࠊᐑᒸభ୍㑻㸸CRISPR/Cas9 ࡟ࡼࡿ┦ྠ⤌᥮࠼ಟ᚟㸦HDR㸧ࢆ௓ࡋࡓṇ☜࡞ࢤࣀ࣒⦅㞟ࢆಁ㐍ࡍࡿ᮲௳ࡢ ➨ 91 ᅇ ᪥ᮏ⏕໬Ꮫ఍኱఍ 2018.9.26 ி㒔㸦ཱྀ㢌Ⓨ⾲㸧

ࡑࡢ௚ 㸦ィ 6 ௳㸧⮬⏤ᥖ㍕
1.

チ⤬ⲓࠊᐑᒸభ୍㑻㸸ࣇ࢓ࣈ࣮ࣜ⑓ࡢ iPS ⣽⬊⛣᳜἞⒪ࢆ┠ᣦࡋ࡚࠸ࡲࡍ ᫂἞⸆⛉኱Ꮫ⮫ᗋ㑇ఏᏛබ㛤ࢩ࣏ࣥࢪ࣒࢘ 2018.12.14 ᮾி㒔Ύ℩－ 96 －

2.

Tomoko Kato, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka: Modified interactions between
Cas9/Cas9 D10A nickase and genomic DNA enhances HDR, Cold Spring Harbor Laboratory,
Genome Engineering: The CRISPR/Cas Revolution Meeting 2018 2018.8.24,  Cold Spring
Harbor㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

3.

Tomoko Kato, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka: Genome editing via Cas9 RNP
improves the HDR/NHEJ ratio, Cold Spring Harbor Laboratory Meeting Genome Engineering: The
CRISPR-Cas Revolution 2018㻌 2018.8.23

4.

Cold Spring Harbor㸦࣏ࢫࢱ࣮Ⓨ⾲㸧ຍ⸨-஝᭸Ꮚࠊ㧗ᶫ๛ࠊチ⤬ⲓࠊᐑᒸభ୍㑻㸸Cas9-DNA ┦஫స⏝ࡢᨵኚ࡟ࡼࡿࢤࣀ࣒⦅㞟ࡢṇ☜ᛶྥୖࡣྠ᫬࡟ HDR ㄏᑟάᛶࡶ㧗ࡵࡿ ➨ 3 ᅇ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍ᖺ఍2018.6.20 ᗈᓥ㸦࣏ࢫࢱ࣮Ⓨ⾲㸧5.

㧗ᶫ๛ࠊチ⤬ⲓࠊᐑᒸభ୍㑻㸸ᝈ⪅⏤᮶ iPS ⣽⬊࡟࠾ࡅࡿ CRISPR/Cas9 ࢆ⏝࠸ࡓⅬኚ␗ࡢಟ᚟ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍ ➨ 3 ᅇ኱఍ 2018.6.19 ᗈᓥ㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

6.

ຍ⸨᭸Ꮚࠊ㧗ᶫ๛ࠊチ⤬ⲓࠊᐑᒸభ୍㑻㸸Cas9 ࣜ࣎᰾ࢱࣥࣃࢡ㉁(RNP)ࢆ௓ࡋࡓࢤࣀ࣒⦅
㞟ࡣ HDR/NHEJ ẚࢆஹ㐍ࡍࡿ ➨ 3 ᅇ ᪥ᮏࢤࣀ࣒⦅㞟Ꮫ఍ 2018.6.19 ᗈᓥ㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 4 ௳㸧ᐑᒸభ୍㑻㸸ࢤࣀ࣒⦅㞟ࡢᇶ♏࡜ᛂ⏝ ~◊✲ືྥ࣭་⒪ࡸ⏘ᴗ࡬ࡢᛂ⏝࣭௒ᚋࡢㄢ㢟~ ᰴᘧ఍♫᝟ሗᶵᵓࢭ࣑ࢼ࣮ 2019.1.23 ᮾி㸦ㅮ₇㸧ᐑᒸభ୍㑻㸸ࡇࢀ࠿ࡽ⏕࿨⛉Ꮫ◊✲⪅ࢆ┠ᣦࡍ㸦࠿ࡶࡋࢀ࡞࠸㸧㧗ᰯ⏕࡬ࡢ1 ࡘࡢᣦ㔪㧗ᰯ⏕ࡢࡓࡵࡢ㒔་Ꮫ◊ࣇ࢛࣮࣒ࣛ 2018.8.1〜2 ᮾி㸦ㅮ₇㸧ᯘὒᖹࠊᐑᒸభ୍㑻㸸㒔Ẹㅮᗙ iPS⣽⬊ࢆ⏝࠸ࡓ⑌ᝈ◊✲࣭἞⒪ἲ㛤Ⓨࡢ᭱๓⥺ 2018.7.4
ᮾி 㸦ㅮ₇㸧ᐑᒸభ୍㑻㸸ࢤࣀ࣒⦅㞟ࡢᇶ♏࡜iPS ⣽⬊࡟ࡼࡿ⑌ᝈࣔࢹࣝ࡬ࡢᛂ⏝ BIO tech 2018
2018.6.29 ᮾி㸦ㅮ₇㸧

IV. ≉グ஦㡯1.

ᐑᒸభ୍㑻㸸ࢺࢥࢺࣥࡸࡉࡋ࠸ࢤࣀ࣒⦅㞟ࡢᮏ (௒᪥࠿ࡽࣔࣀ▱ࡾࢩ࣮ࣜࢬ) ᪥หᕤᴗ᪂
⪺♫ࡼࡾฟ∧㸦2019.3.20 ฟ∧㸧2.

ᐑᒸభ୍㑻㸸NHK World JapanࠊNHK-BS1 ࡢ Genome Science Editing Humanity's Future GLOBAL AGENDA ࡜࠸࠺␒⤌ࡢ┘ಟ㸦2019.3.2 ࡟ᨺ㏦㸧3.

ᐑᒸభ୍㑻㸸ࠕ⏕࿨⛉Ꮫ◊✲⪅ࡢᐇែࠖ ඵᖭᒣᑠᏛᰯ ➨㸲ᅇ࢟ࣕࣜ࢔ᩍ⫱ᨭ᥼ࣉࣟࢪ
࢙ࢡࢺ㸦2019.2.26㸧ᑠᏛ㸴ᖺ⏕࡟ྥࡅࡓㅮ₇

4.

ᐑᒸభ୍㑻㸸ࣛࢪ࢜ NIKKEI ་Ꮫㅮᗙࠕ᪂ࡓ࡞᫬௦࡟✺ධࡋࡓ iPS ⣽⬊◊✲ࠖ⊂₇
㸦2018.12.18㸧

5.

ᐑᒸభ୍㑻㸸᪥ᮏ⤒῭᪂⪺ ෌⏕་⒪ 㣕㌍࡬ࡢヨ⦎㸦ୗ㸧iPS ࡜᪂ᢏ⾡⤖㞟࡜࠸࠺グ஦࡟ࢥ࣓ࣥࢺࡀᥖ㍕ࡉࢀࡓ㸦2018.7.2 ࡢᮅห㸧－ 97 －

ࣉࣟࢪ࢙ࢡࢺྡ

⬻༞୰ࣝࢿࢧࣥࢫࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Ito M, Komai K, Omata-Mise S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K,
Nakayama T, Yoshi O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Brain regulatory T
cells suppress astrogliosis and potentiate neurological recovery. Nature. in press (2018) ᰝㄞ᭷

2.

Yoneda T, Sakai S, Maruoka H, Hosoya T. Large-scale Three-dimensional Imaging of Cellular
Organization in the Mouse Neocortex. Journal of visualized experiments :JoVE 139 (2018) ᰝㄞ᭷ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 8 ௳㸧
1.

Tsuyama J, Nakamura A, Ooboshi H, Yoshimura A, Shichita T. Pivotal role of innate myeloid cells
in cerebral post-ischemic sterile inflammation. Semin Immunopathol. (2018)2.

Sakai S, Shichita T. Inflammation and neural repair after ischemic brain injury. Neurochem Int.
(2018)

3.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ↓⳦ⓗ⅖⑕࡜࣐ࢡࣟࣇ࢓࣮ࢪ㸬⣽⬊ : (2018)4.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⮬↛ච␿⣔ࡢ࠿࠿ࢃࡾ㸬་Ꮫࡢ࠶ࡺࡳ 265(13):1292-1295 (2018)5.

୰ᮧᖾኴ㑻ࠊ୰ᮧᮒ㔛ࠊ኱ᫍ༤᫂ࠊ୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕ࡢᙺ๭㸬᪥ᮏ⬻ᚠ⎔௦ㅰᏛ఍㞧ㄅ (2018)6.

୐⏣ᓫ㸸⬻༞୰⑓ែᏛࡢࢫࢫ࣓ࠕ13.D. ⚄⤒⣽⬊ಖㆤ⒪ἲ ච␿ⓗ࢔ࣉ࣮ࣟࢳࠖ251-256(2018)

7.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ⅖⑕ច㉳࣭཰᮰࣓࢝ࢽࢬ࣒㸬᪥ᮏ⸆⌮Ꮫ㞧ㄅ 151(1):9-14 (2018)8.

୐⏣ᓫࠊྜྷᮧ᫛ᙪ㸸ࢫ࢝࣋ࣥࢪ࣮ࣕཷᐜయࢆ௓ࡋࡓ↓⳦ⓗ⅖⑕ࡢ཰᮰࣓࢝ࢽࢬ࣒㸬⏕໬Ꮫ
90(1):99-102 (2018)

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 10 ௳㸧1.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ↓⳦ⓗ⅖⑕ࡢ࣓࢝ࢽࢬ࣒ ➨ 44 ᅇ᪥ᮏ⬻༞୰Ꮫ఍Ꮫ⾡⥲఍
2019.3.21 ࣃࢩࣇ࢕ࢥᶓ὾ ⚄ዉᕝ┴ᶓ὾ᕷ㸦ཱྀ㢌Ⓨ⾲㸧

2.

୐⏣ᓫ㸸⬻⹫⾑࡟࠾ࡅࡿ⣽⬊Ṛ࡜⅖⑕ไᚚ ⏕యࢩࢫࢸ࣒㐃㛵◊✲఍ 2018.11.12 රᗜ┴ῐ㊰ᕷ 㸦ཱྀ㢌Ⓨ⾲㸧

3.

Shichita T㸸 Sterile inflammation induced by ischemic brain cell death. ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍
኱఍ 2018.9.25 ி㒔ᗓ㸦ཱྀ㢌Ⓨ⾲㸧

4.

୐⏣ᓫ㸸⬻᱾ሰ࡟࠾ࡅࡿ↓⳦ⓗ⅖⑕ࡢ࣓࢝ࢽࢬ࣒ ➨ 61 ᅇ᪥ᮏ⚄⤒໬Ꮫ኱఍ 2018.9.7
රᗜ┴⚄ᡞᕷ㸦ཱྀ㢌Ⓨ⾲㸧

－ 98 －

5.

୐⏣ᓫ㸸⬻᱾ሰ࡜↓⳦ⓗ⅖⑕ ➨ 2 ᅇ࿴ග㸫⢭⚄⚄⤒᠓ヰ఍ 2018.8.26 㟼ᒸ┴⇕ᾏᕷ㸦ཱྀ
㢌Ⓨ⾲㸧

6.

୐⏣ᓫ㸸⬻᱾ሰᚋ࡟࠾ࡅࡿ↓⳦ⓗ⅖⑕ࡢ࣓࢝ࢽࢬ࣒ Mt.Fuji Workshop on CVD 2018.8.25
ឡ▱┴ྡྂᒇᕷ㸦ཱྀ㢌Ⓨ⾲㸧

7.

୐⏣ᓫࠊὠᒣ῟ࠊ㓇஭ㄔ୍㑻㸸⬻࡜↓⳦ⓗ⅖⑕ ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2018.7.29 රᗜ┴⚄ᡞᕷ㸦ཱྀ㢌Ⓨ⾲㸧

8.

୐⏣ᓫ㸸⬻ෆ⅖⑕ࡢ཰᮰㐣⛬࡟㛵ࢃࡿ࣏ࣜࢡ࢜ࣜࢸ࢕ ➨ 60 ᅇ᪥ᮏ⬡㉁⏕໬Ꮫ఍2018.5.31 ᮾி㒔㸦ཱྀ㢌Ⓨ⾲㸧

9.

Shichita T㸸 Sterile inflammation in ischemic stroke.

Australia-Japan Meeting on Cell Death2018.5.2 ᮾி㒔㸦ཱྀ㢌Ⓨ⾲㸧10. ୐ ⏣ ᓫ 㸸 ⬻ ᱾ ሰ ࡜ ↓ ⳦ ⓗ ⅖ ⑕  㹼 ⅖ ⑕ ࡣ ᩛ ࠿ 㸽 ࿡ ᪉ ࠿ 㸽 㹼  ་ ⛉ ◊ ࣇ ࢛ ࣮ ࣛ ࣒
2018.4.20 ᮾி㒔㸦ཱྀ㢌Ⓨ⾲㸧ࡑࡢ௚ 㸦ィ 4 ௳㸧⮬⏤ᥖ㍕
1.

㓇஭ㄔ୍㑻ࠊ୰ᮧᖾኴ㑻ࠊ୐⏣ᓫ㸸⬻᱾ሰᚋ࡟࠾ࡅࡿ኱⬻᪂⓶㉁ᗈᇦ⚄⤒ᅇ㊰ࡢ෌⦅ ⏕⌮Ꮫ◊✲ᡤ◊✲఍ 2018.9.21 ឡ▱┴ᒸᓮᕷ㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

2.

ᖹᯘဴஓ㸸Phosphatidylcholine catabolism mediated by PNPLAs plays an important role in liverfunction and energy homeostasis㸬 Japan-Korea Lipid Joint Symposium 2018.9.12㹼9.14 ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⸆Ꮫ◊✲ᐊ ໭ᾏ㐨ᮐᖠᕷ

3.

ᖹᯘဴஓ㸸Phosphatidylcholine catabolism mediated by PNPLA7 provides a source of hepatic
methyl groups and controles energy homeostasis㸬 59th International Conference on the Bioscienceof Lipid 2018.9.4㹼9.7 Helsinki,Finland

4.

୐⏣ᓫ㸸Sterile inflammation in ischemic stroke㸬 Australia-Japan Meeting on Cell Death2018.5.22㹼5.23 ᮾி㒔

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 1 ௳㸧
1.

୐⏣ᓫ㸸⬻⾑⟶㞀ᐖ࡟࠾ࡅࡿ⮬↛ච␿࣓࢝ࢽࢬ࣒ࡢゎ᫂ ᖹᡂ 29 ᖺᗘⰼ⋤⛉Ꮫ㈹㉗࿊ᘧ
2018.6.8 ᮾி㒔IV. ≉グ஦㡯
࠙ཷ㈹ࠚ
1.

୐⏣ᓫ㸸᪥ᮏ⚄⤒໬Ꮫ఍ Ꮫ఍㈹ ཷ㈹᪥㸸2018.9.72.

୐⏣ᓫ㸸ⰼ⋤ⱁ⾡࣭⛉Ꮫ㈈ᅋ ⰼ⋤⛉Ꮫ㈹ ཷ㈹᪥㸸2018.6.8࠙ᩍ⫱άືࠚ
1.

୐⏣ᓫ㸸៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊 ⏕≀Ꮫ≉ㄽ 2018.12.182.

୐⏣ᓫ㸸ᮾி኱Ꮫ኱Ꮫ㝔 ࠕ㣗ရᶵ⬟໬Ꮫࠖ 2018.10.23

3.

ὠᒣ῟㸸ᮾிᐙᨻᏛ㝔኱Ꮫ ೺ᗣᰤ㣴Ꮫ⛉ ᢸᙜ⛉┠㸸⑓ཎᚤ⏕≀Ꮫ 2018.4.1㹼9.30－ 99 －

ࣉࣟࢪ࢙ࢡࢺྡ

㐠ື㞀ᐖࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

Tanaka H, Ishikawa T, *Kakei S. Neural evidence of the cerebellum as a state predictor. Cerebellum,
㸦in press㸧㸦ᰝㄞ᭷㸧.

2.

*Kakei S, Ishikawa T, Lee J, Honda T, Hoffman DS. Physiological principles of the cerebellar
reserve. In Eds. Mitoma H and Mario M.

Special Issue for CNS & Neurological Disorders – Drug

Targets, 17:184-192 㸦2018㸧㸦ᰝㄞ᭷㸧.
3.
4.

Min K, Shin D, Lee J, *Kakei S.

Electromyogram refinement using muscle synergy based

regulation of uncertain information.

J Biomech, 72-125-133 㸦2018㸧㸦ᰝㄞ᭷㸧.

*Min K, Iwamoto M, Kimpara H, Kakei S. Muscle synergy-driven robust motion control. NeuralComputation,㸦2018㸧㸦ᰝㄞ᭷㸧.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.
2.

*⟍ ៅ἞ ࠕື≀ࡢ㎡඾ࠖ➨ 8 ❶ ື≀ࡢ⬻࣭⚄⤒⣔ ➨ 4 ⠇ ⬻ࡢാࡁ 8.4.1 㐠ືไᚚ (ᰝㄞ࡞ࡋ).
*⟍ ៅ἞ࠊᮏከṊᑛࠊᮤ 㙂ᪿࠊྜྷ⏣኱ᓠࠊΏ㒊㞞ஓࠊ㏆⸨ᩄஅࠊ୕Ɫ༤ࠊỈ⃝ⱥὒ.ࠕᑠ
⬻ኻㄪࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ་⒪—ୖ⫥࡟ࡘ࠸࡚—ࠖ㸪The Japanese Journal of Rehabilitation
Medicine, 56(2)㸦2018㸧(ᰝㄞ࡞ࡋ).

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 8 ௳㸧1.

⟍ ៅ἞ ࠕ⬨᳝ື≀ࡢ㐠ືไᚚࡢ㉳※࡜㐍໬㸸a brief history of neural control of movementࠖ᪥ᮏ Motor Control ◊✲఍࣭෤ᮇㅮ⩦఍ࣞࢡࢳ࣮ࣕ 2019.1.5

2.

Kakei S. “Future of Big Data and AI in Neuroscience.”

Advances in neuroinformatics 2018.

⌮໬Ꮫ◊✲ᡤ኱Ἑෆグᛕ࣮࣍ࣝ 2018.12.21 ᇸ⋢┴࿴ගᕷ3.

Kakei S. “Cerebro-cerebellar communication loop: its contribution to cognitive brain functions.”
The 75th FUJIHARA Seminar: “The Cerebellum as a CNS hub – from its evolution to therapeuticstrategies” 2018.12.4 ᮾி་⛉ṑ⛉኱Ꮫ ᮾி㒔

4.

Kakei S. “Physiological basis of cerebellar ataxia.” The 4th Taiwan International Congress of
Parkinson’s Disease and Mvement Disorders. Taiwan International Convention Center2018.11.25 ྎ‴

5.

⟍ ៅ἞ ࠕ⚄⤒⑌ᝈࢆホ౯ࡍࡿ➨ 3 ࡢ┠ࡢ㛤Ⓨࠖ ➨ 18 ᅇ Conference for BioSignal andMedicine, CBSM2018  2018.10.6 KKR ࣍ࢸࣝ㙊಴ࢃ࠿ࡳࡸ

6.

⟍ ៅ἞ ࠕBRAIN Initiative ࡢඛࢆぢᤣ࠼࡚ࠖ➨➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭ࣛࣥࢳࣙࣥ኱ウㄽ఍ 2018.7.26 ⚄ᡞᅜ㝿఍㆟ሙ

－ 100 －

7.

⟍

ៅ ἞  ”Dynamic cerebellum: neural mechanisms underlying emerging information

processing” ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭බເࢩ࣏ࣥࢪ࣒࢘ 2018.7.25 ⚄ᡞᅜ㝿఍㆟ሙ
8.

⟍ ៅ἞ ࠕ␗ᖖ㐠ືࡢศᯒࢆ἞⒪࡟⏕࠿ࡍ᪂ࡋ࠸࢔ࣉ࣮ࣟࢳࠖ ➨ 2 ᅇࠕ⚄⤒⑌ᝈࢆ⪃࠼ࡿࠖ㸫ࠗᇶ♏࠘࡜ࠗ⮫ᗋ࠘ࡢ⼥ྜ㸫 2018.7.18 ᅜศᑎᕷ❧࠸ࡎࡳ࣮࣍ࣝ

ࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

Min K, Iwamoto M, Kakei S. (December, 2018). “Motion control robustness driven by muscle
synergy strategy”

2nd International Symposium on Embodied-Brain Systems Science 2018, P-41

2018.12.5 ༓㔛ࣛ࢖ࣇࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮
2.

Ishikawa T and Kakei S “The cerebrocerebellum provide both intrinsic and extrinsic information for
cerebral motor area.” 2nd International Symposium on Embodied-Brain Systems Science 2018, P-41
2018.12.5. ༓㔛ࣛ࢖ࣇࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮ ኱㜰

3.

Min K, Iwamoto M, Kakei S. (July, 2018). Simulation analysis for the contribution of Muscle
Synergy to Robust Motion Control, ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ఍኱఍ 2P-361  2018.7.25

4.

㛬 ᗒ⏠ࠊ⟍ ៅ἞ ࠕ➽ࡢ༠ㄪไᚚࣔࢹࣝࢆ⏝࠸ࡓ➽㟁ᅗಙྕࡢࣜࣇ࢓࢖ࣥࣔࢹࣝ࡜
Myoelectric control ࡬ࡢᒎ㛤ࠖ, Conference for BioSignal and Medicine, p. 25,  2018.10.5.

5.

Honda T, Bando K, Yoshida H, Yodu A, Kondo T, Yokota T, Ishikawa K, Mizusawa H, Nagao S,
Hanakawa T, Kakei S. “Relation of motor control with cerebellar motor learning in cerebellar
degeneration”, ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2018.7.26㹼7.29 ⚄ᡞ

6.

ᮏከṊᑛࠊᐑ⏣ୡ⩚ࠊụ⃝῟ࠊྜྷ⏣኱ᓠࠊ㏆⸨ᩄஅࠊ⇃⏣⪽ᏊࠊᶓᆅᡣᏊࠊ⟍ ៅ἞. “῝ᗘࢭࣥࢧ࡟ࡼࡿ⬻῝㒊่⃭⒪ἲ࡛ࡢ่⃭ᙉᗘ࡜ୖ⫥㐠ືࡢᐃ㔞ホ౯”, ➨ 33 ᅇ᪥ᮏ኱⬻ᇶᗏ᰾◊✲఍ 2018.8.25 ᮾி

7.

ᮏከṊᑛࠊᐑ⏣ୡ⩚ࠊụ⃝ ῟ࠊྜྷ⏣኱ᓠࠊ㏆⸨ᩄஅࠊ⇃⏣⪽ᏊࠊᶓᆅᡣᏊࠊ⟍ ៅ἞. “῝ᗘࢭࣥࢧࢆ౑ࡗࡓ⮬ືデ᩿ࢩࢫࢸ࣒”, ➨ 18 ᅇ Conference for BioSignal and Medicine (CBSM)
2018.10.5 㙊಴III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯࠙≉チฟ㢪ࠚ
1.

ᅜෆ≉チⓏ㘓࠙Ⓨ᫂⪅ࠚ⟍ៅ἞ࠊᮤ㙂ᪿࠊ⧊ⱱᬛஅࠊ✄ⴥᙲࠊᒸ⏣Ᏻᘯ࠙Ⓨ᫂ࡢྡ⛠ࠚ㐠ືᶵ⬟ゎᯒࢩࢫࢸ࣒࠾ࡼࡧࡑࡢࢩࢫࢸ࣒ࡢసື᪉ἲ࠙≉チⓏ㘓᪥ࠚ2018.4.13࠙≉チ␒ྕࠚ
≉チ➨ 6322624 ྕ

࠙ࡑࡢ௚ࠚ
1.

2018 ᖺᗘ࣭➨ 75 ᅇ ⸨ཎࢭ࣑ࢼ࣮ “Cerebellum as a CNS hub - from its evolution to therapeuticstrategy”ඹྠ࣮࢜࢞ࢼ࢖ࢬ ᮾி་⛉ṑ⛉኱Ꮫ࣭㕥ᮌ❶ኵグᛕㅮᇽ 2018.12.1㹼12.4

2.

➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍࣭බເࢩ࣏ࣥࢪ࣒࢘ ”Dynamic cerebellum: neural mechanisms
underlying emerging information processing” ࣮࢜࢞ࢼ࢖ࢬ ⚄ᡞᅜ㝿఍㆟ሙ 2018.7.25－ 101 －

ࣉࣟࢪ࢙ࢡࢺྡ

どぬ⑓ែࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 3 ௳㸧
1.

Sano, H., Namekata, K., Kimura, A., Shitara, H., Guo, X., Harada, C., Mitamura, Y. and Harada, T.
Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal
tension glaucoma. Cell Death and Disease 10(2), 75, 2019.

2.

Akaiwa, K., Namekata, K., Azuchi, Y., Sano, H., Guo, X., Kimura, A., Harada, C., Mitamura, Y. andHarada, T. Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal
tension glaucoma. Investigative Ophthalmology & Visual Science 59(5), 2080-2089, 2018.

3.

Azuchi, Y., Namekata, K., Shimada, T., Guo, X., Kimura, A., Harada, C., Nishigaki, A., Yamagata,
K. and Harada, T. Role of neuritin in retinal ganglion cell death in adult mice following optic nerve
injury. Scientific Reports 8(1), 10132, 2018.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 2 ௳㸧
1.

Harada, C., Kimura, A., Guo, X., Namekata, K. and Harada, T. Recent advances in geneticallymodified animal models of glaucoma and their roles in drug repositioning. British Journal of
Ophthalmology 103(2), 161–166, 2019.

2.

ཎ⏣㧗ᖾ. ⥙⭷⚄⤒ಖㆤ࡜㍈⣴෌⏕◊✲. ║⸆⌮ 32(1), 40-42, 2018.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 2 ௳㸧
1.

ᮌᮧᩔᏊ. Can valproic acid treat neurodegenerative diseases? International Conference on
Neurovascular and Neurodegenerative Diseases, 2018.10.15, Narita, Japan (INVITED)2.

㒌 ᬡ㯇. New therapeutic targets on neurodegenerative and demyelination diseases. Overseas
Chinese, Chinese and High-Level Talents Travel to Jiangsu. 2018.8.23, Yancheng, Jiangsu, China(INVITED)ࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

ཎ⏣㧗ᖾ. Spontaneous normal tension glaucoma in aged marmosets. 8th World Glaucoma
Congress (WGC 2019), 2019.3.30, Melbourne, Australia

2.

ᏳᅵࡺࡾᏊ Loss of neuritin accelerates RGC loss and retinal degeneration in adult mice following
optic nerve injury. Annual Meeting of the Society for Neuroscience, 2018.11.5, San Diego, USA3.

⾜ ᪉ ࿴ ᙪ .  DOCK8 regulates microglial activity in neuroinflammation. 19th International
Congress of Neuropathology, 2018.9.26, Tokyo, Japan4.

ᮌᮧᩔᏊ. Manipulation of retinal glutamate levels by overexpression of GLAST reduces retinal－ 102 －

ganglion cell death in an experimental model of glaucoma. 19th International Congress of
Neuropathology, 2018.9.25, Tokyo, Japan5.

ཎ⏣㧗ᖾ. Topical ripasudil prevents retinal ganglion cell death in a mouse model of normal
tension glaucoma. 13th European Glaucoma Society Congress, 2018.5.20, Florence, Italy6.

㒌 ᬡ㯇. Dock10 deficiency reduces neuroinflammation in optic neuritis. The ARVO (Association
for Research in Vision and Ophthalmology) Annual Meeting 2018, 2018.5.1, Hawaii, USA

7.

㉥ᒾ៞ࠊ⾜᪉࿴ᙪࠊᏳᅵࡺࡾᏊࠊ㒌 ᬡ㯇ࠊᮌᮧᩔᏊࠊཎ⏣▱ຍᏊࠊ୕⏣ᮧె඾ࠊཎ⏣㧗ᖾ.
ṇᖖ║ᅽ⥳ෆ㞀ࣔࢹ࣐ࣝ࢘ࢫࢆ⏝࠸ࡓ Edaravone ࡟ࡼࡿ⥙⭷⚄⤒⠇⣽⬊ಖㆤຠᯝࡢ᳨ウ.
➨ 122 ᅇ᪥ᮏ║⛉Ꮫ఍⥲఍, 2018.4.19, ኱㜰ᅜ㝿఍㆟ሙ㸦኱㜰ᗓ㸧

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 9 ௳㸧1.

㔠 ⩏㐨ࠊᮏ⏣⣪㔛ࠊᏳᅵࡺࡾᏊࠊ㒌ᬡ㯇ࠊᮌᮧᩔᏊࠊ⾜᪉࿴ᙪࠊཎ⏣㧗ᖾ.
どᶵ⬟ᅇ᚟࡟ྥࡅࡓ᪂つ㑇ఏᏊ἞⒪࣋ࢡࢱ࣮ࡢ㛤Ⓨ.

ኻ᫂࠿ࡽࡢ➨ 4 ᅇ TMED ࣇ࢛࣮࣒ࣛ,2019.3.13, ከᦶ⥲ྜ་⒪ࢭࣥࢱ࣮࣭ᑠඣ⥲ྜ་⒪ࢭࣥࢱ࣮
2.

ཎ⏣㧗ᖾ. ᭱᪂ࡢ◊✲࠿ࡽࢃ࠿ࡗࡓࡇ࡜ࠥ⥳ෆ㞀࡜࠺ࡲࡃࡘࡁ࠶࠺࡟ࡣ㸽 ᖹᡂ 30 ᖺᗘ㒔་Ꮫ◊㒔Ẹㅮᗙࠕ➨ 8 ᅇ ⥳ෆ㞀࠿ࡽ┠ࢆᏲࡿࡓࡵ࡟ࠖ 2019.2.15, ୍ᶫㅮᇽ㸦ᮾி㒔㸧

3.

ᮏ⏣⣪㔛ࠊ⾜᪉࿴ᙪࠊᮌᮧᩔᏊࠊ㒌ᬡ㯇ࠊཎ⏣㧗ᖾ. ⥳ෆ㞀ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ㧗⪏ᛶࢽ࣮ࣗࣟࣥࡢ᳨ウ. ᖹᡂ 30 ᖺᗘᡤෆ◊✲Ⓨ⾲఍➨ 3 㒊఍, 2019.2.14, ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ4.

㔠 ⩏㐨ࠊᮏ⏣⣪㔛ࠊᏳᅵࡺࡾᏊࠊ㒌ᬡ㯇ࠊᮌᮧᩔᏊࠊ⾜᪉࿴ᙪࠊཎ⏣㧗ᖾ.
どᶵ⬟ᅇ᚟࡟ྥࡅࡓ᪂つ㑇ఏᏊ἞⒪࣋ࢡࢱ࣮ࡢ㛤Ⓨ.

ኻ᫂࠿ࡽࡢᖹᡂ 30 ᖺᗘᡤෆ◊✲Ⓨ⾲఍➨ 3 㒊

఍, 2019.2.14, ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ
5.

ᮌᮧᩔᏊ. Overexpression of GLAST protects retinal ganglion cells in an experimental model ofglaucoma.

6.

ᖹᡂ 30 ᖺᗘᡤෆ◊✲Ⓨ⾲఍➨ 1 㒊఍, 2018.11.19, ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤཎ⏣㧗ᖾ. The EYE. Development, Diseases & Regeneration. 㜵⾨་⛉኱Ꮫᰯ ෌⏕࣭Ⓨ⏕Ꮫㅮ⩏, 2018.9.11, 㜵⾨་⛉኱Ꮫᰯ㸦ᇸ⋢┴㸧

7.

ཎ⏣㧗ᖾ.ど⚄⤒ࡢಖㆤ࡜෌⏕. ᖹᡂ 30 ᖺᗘ S ࢭ࣓ࢫࢱ࣮ࠕ඲Ꮫయ㦂ࢮ࣑ࢼ࣮ࣝࠖ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ㸦ᮾி኱Ꮫᩍ㣴Ꮫ㒊㸧, 2018.7.1 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ
8.

ཎ⏣㧗ᖾ. The EYE. Development, Diseases & Regeneration. ໭ᾏ㐨኱Ꮫ་Ꮫ㒊║⛉Ꮫㅮ⩏,2018.6.25, ໭ᾏ㐨኱Ꮫ㸦໭ᾏ㐨㸧9.

ཎ⏣㧗ᖾ. N-acetylcysteine ࠾ࡼࡧ ROCK 㜼ᐖ๣࡟ࡼࡿ⚄⤒ಖㆤຠᯝ. ໭ᾏ㐨኱Ꮫࣜࢧ࣮
ࢳ࢝ࣥࣇ࢓ࣞࣥࢫ, 2018.6.25, ໭ᾏ㐨኱Ꮫ㸦໭ᾏ㐨㸧

IV. ≉グ஦㡯1.

ཎ⏣㧗ᖾ ᖹᡂ 30 ᖺᗘࠕ➨ 8 ᅇ ⥳ෆ㞀࠿ࡽ┠ࢆᏲࡿࡓࡵ࡟ࠖࢆᢸᙜ. ₇㢟ࠕ᭱᪂ࡢ◊✲࠿ࡽࢃ࠿ࡗࡓࡇ࡜ࠥ⥳ෆ㞀࡜࠺ࡲࡃࡘࡁ࠶࠺࡟ࡣ㸽ࠖ2019.2.15

2.

㒌 ᬡ㯇ࡢ◊✲ᡂᯝ㸦Am J Pathol, 2017㸧ࡀ௨ୗࡢࢧ࢖ࢺ࡛⤂௓.
MEDICINE INNOVATES 䛂Role of Renin-Angiotensin System in Optic Neuritis䛃
https://medicineinnovates.com/mechanism-of-action/role-renin-angiotensin-system-optic-neuritis/

3.

2018.4.24 ᪥หࢤࣥࢲ࢖࡟◊✲ෆᐜ⤂௓ ࠗே⏕ 100 ᖺ᫬௦ࢆᨭ࠼ࡿ ὀ┠ࡢ་⒪ࠕ᪂ࡋ࠸⥳ෆ㞀἞⒪ࠖࢱࣇ࡞ど⚄⤒ࢆࡘࡃࡾࠊど⚄⤒㞀ᐖࢆᨵၿࡍࡿ 3 ࡘࡢᡭẁ࠘
https://hc.nikkan-gendai.com/articles/227793?page=1－ 103 －

ࣉࣟࢪ࢙ࢡࢺྡ

㞴⑓ࢣ࢔┳ㆤࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 7 ௳㸧
1.

Shimizu T, Nakayama Y, Matsuda C, Haraguchi M, Bokuda K, ,VKLNDZDဩ7DNDWD .  .DZDWD$
Isozaki EPrognostic significance of body weight variation after diagnosis in ALS: a single-centre
prospective cohort study. Journal of Neurology doi: org/10.1007/s00415-019-09276-2

2.

Matsuda C, Shimizu T, Nakayama Y, Haraguchi M, Cough peak flow decline rate predicts survival
in patients with amyotrophic lateral sclerosis. Muscle & Nerve. 2018. doi: 10.1002/mus.26320.

3.

Kamei T. Yamamoto Y, Kanamori T, Nakayama Y, Sarah E Poter, Detection of early-stage changes
in people with chronic diseases: A telehome monitoring-based telenursing feasibility study. Nursingand Health Science.2018DOI: 10.1111/nhs.12563

4.

Shimizu T, Bokuda K, Kimura H, Kamiyama T, Nakayama Y, Kawata A, Isozaki E, Ugawa Y.
Sensory cortex hyperexcitability predicts short survival in amyotrophic lateral sclerosis. Neurology
2018;90(18): e1578-e1587.

5.

Nakayama Y, Shimizu T, Matsuda C, Mochizuki Y, Hayashi K,Nagao M, Kawata A, Isozaki E, NonMotor Manifestations in ALS Patients with Tracheostomy and invasive ventilation. Muscle andNerve. 2018.57(5):735-741. DOI:10.1002/mus.26004

6.

ཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᮧ⏣ຍዉᏊࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊ ᅾᏯ་⒪ࢆせࡍࡿ⒪㣴⪅ࡢᨭ᥼࡟࠾ࡅࡿ┳ㆤ⫋࡜௓ㆤ⫋ࡢ㐃ᦠᣦᶆࡢ㛤Ⓨ㸫ಙ㢗ᛶ࣭ጇᙜᛶࡢ᳨ウ㸫㸬᪥ᮏᅾᏯ┳ㆤᏛ఍ㄅ 2018.6(2) : 35-44.
7.

ᯈᇉࡺࡳࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊࠊᑠ᳃ဴኵ ᅾᏯேᕤ࿧྾ჾ౑⏝≉ᐃ⑌ᝈᝈ⪅ゼၥ┳ㆤ἞⒪◊✲஦ᴗ࡟ࡼࡿゼၥ┳ㆤࡢᐇែ ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ,2018.22(3),269-276.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 20 ௳㸧1.

୰ᒣඃᏘ*ࠊཎཱྀ㐨Ꮚࠊᑠ᳃ဴኵࠊᑠ಴ᮁᏊࠊᮏ⏣ᙲᏊࠊᑠ㛗㇂ⓒ⤮ 㞴⑓࡟࠾ࡅࡿ┳ㆤᖌࡢᙺ๭ 㹼᪂ࡓ࡞་⒪ᥦ౪యไୗ࡟ồࡵࡽࢀࡿ┳ㆤᐇ㊶㹼 ᖹᡂ 30 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩

2.

୰ᒣඃᏘ*ࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊᑠ᳃ဴኵࠊᐑཎ⯙ 㞴⑓ᝈ⪅ࡢ⏕άᐇែㄪᰝ㹼㞴⑓ᝈ⪅ࡢ≧ែീࡢ㢮ᆺ໬࡜⤒㐣ᥐ⨨⤊஢ᚋࡢ㞴⑓ᝈ⪅ࡢ≧ἣ㹼 ᖹᡂ 30ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩3.

୰ᒣඃᏘ*ࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊᑠ᳃ဴኵ ᅾᏯேᕤ࿧྾ჾ౑⏝㞴⑓ᝈ⪅ᨭ᥼஦ᴗࡢ฼⏝≧ἣ࡜ᥦ౪ࡉࢀࡓ┳ㆤෆᐜ ᖹᡂ 30 ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦
ᴗ㈝⿵ຓ㔠㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩－ 104 －

 ୰ᒣඃᏘ㸦⥲ㄝ㸧 ⚄⤒㞴⑓ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ࡟ぶࡋࡴ ̿┳ㆤ࡛࡛ࡁࡿ⚄⤒㞴⑓ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࢆ┠ᣦࡋ࡚̿ ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄅ   ࠊ ୰ᒣඃᏘ㸦ศᢸᇳ➹㸧 㞴⑓ࡢேࡢ┳ㆤゼၥ┳ㆤᇶᮏࢸ࢟ࢫࢺྛㄽ⦅ࠊ᪥ᮏゼၥ┳ㆤ㈈ᅋ
┘ಟࠊ᪥ᮏ┳ㆤ༠఍ฟ∧఍ࠊ㸬ࠊ⥲࣮࣌ࢪ  ୰ᒣඃᏘ㸦ศᢸᇳ➹㸧 ゼၥ┳ㆤ࠾ᝎࡳ┦ㄯᐊᖹᡂ 30 ᖺᗘᨵᐃᑐᛂ∧ࠊ᪥ᮏゼၥ┳ㆤ㈈ᅋ
⦅㞟ࠊ ୰ኸἲつࠊᮾிࠊ ୰ᒣඃᏘ㸦ศᢸᇳ➹㸧 ་⒪ฎ⨨ࡀᚲせ࡞ேࡢࢣ࢔ ࡼࡃࢃ࠿ࡿᆅᇦໟᣓࢣ࢔ 㝮⏣ዲ⨾ࠊ⸨஭༤ᚿࠊ㯮⏣◊஧⦅ⴭࠊࠊ࣑ࢿࣦࣝ࢓᭩ᡣࠊࠊ⥲࣮࣌ࢪ  ୰ᒣඃᏘ㸦⥲ㄝ㸧≉㞟 ᭱᪂ࡢேᕤ࿧྾⒪ἲ ࢣ࢔ࢩࢫࢸ࣒ࡢ⌧≧࡜ㄢ㢟㞴⑓࡜ᅾᏯࢣ࢔
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 ཎཱྀ㐨Ꮚ㸦ศᢸᇳ➹㸧 ⒪㣴⎔ቃࡢᩚഛ࡜♫఍㈨※ࡢά⏝ࠊゼၥ┳ㆤᇶᮏࢸ࢟ࢫࢺ ྛㄽ⦅ࠊ᪥ᮏ┳ㆤ༠఍ฟ∧఍ࠊ ⥲࣮࣌ࢪ ࠊ㸫 ཎཱྀ㐨Ꮚ㸦⦅ⴭ㸧᭱᪂௓ㆤ⚟♴ኈ㣴ᡂㅮᗙ ་⒪ⓗࢣ࢔ࠊ୰ኸἲつฟ∧ࠊ ⥲࣮࣌ࢪ  ཎཱྀ㐨Ꮚ㸦ศᢸᇳ➹㸧 㞴⑓ಖ೺άື ಖ೺ᖌᅜᐙヨ㦂ࡢࡓࡵࡢࣞࣅ࣮ࣗࣈࢵࢡ 2019 ➨19 ∧ࠊ ་⒪᝟ሗ⛉Ꮫ◊✲ᡤ⦅㞟ࠊ ࠊ ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔
 ཎཱྀ㐨Ꮚ㸦ศᢸᇳ➹㸧 㞴⑓ಖ೺άື ࢡ࢚ࢫࢳࣙࣥࣂࣥࢡಖ೺ᖌᅜᐙヨ㦂ၥ㢟ゎㄝ 2019➨ 19 ∧ࠊ ་⒪᝟ሗ⛉Ꮫ◊✲ᡤ⦅㞟ࠊ ࠊ ᰴᘧ఍♫࣓ࢹ࢕ࢵࢡ࣓ࢹ࢕࢔
 ཎཱྀ㐨Ꮚ ࠊᑠ᳃ဴኵࠊ୰ᒣඃᏘࠊᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊ➟ཎᗣ௦ 㞴⑓ᆅᇦᨭ᥼ࢿࢵࢺ࣮࣡ࢡ࡟࠾ࡅࡿከ⫋✀㐃ᦠ◊ಟ࡟㛵ࡍࡿ᳨ウ ᖹᡂ  ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩ ᑠ಴ᮁᏊ 㞴⑓⒪㣴ᨭ᥼࡟࠾ࡅࡿಖ೺ᡤ➼ಖ೺ᖌࡢάື࣭ᙺ๭࡜㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ࡢά⏝ ಖ೺ᖌࢪ࣮ࣕࢼࣝ 㸦㸧ࠊ㸦ᰝㄞ↓㸧 ᑠ಴ᮁᏊ㸦ศᢸᇳ➹㸧 㞴⑓ࡇࢀ࡛౑࠼ࡿಖ೺ᖌࡢࡓࡵࡢࢹ࣮ࢱά⏝ࣈࢵࢡ. ᮾிᅗ᭩ࠊ
ࠊ⥲࣮࣌ࢪ  ᑠ಴ᮁᏊࠊᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᑠ᳃ဴኵ 㞴⑓ᑐ⟇ᆅᇦ༠㆟఍ࡢᬑཬ࡜㞴⑓ಖ೺άືไᩚഛ ᖹᡂ  ᖺᗘཌ⏕ປാ⾜ᨻ᥎㐍ㄪᰝ஦ᴗ㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈ➼ᨻ⟇◊✲஦ᴗ㸦㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸧ศᢸ◊✲ሗ࿌᭩ ᯇ⏣༓᫓㸦ศᢸᇳ➹㸧 㞴⑓ࡢேࡢ┳ㆤࠊゼၥ┳ㆤᇶᮏࢸ࢟ࢫࢺ ྛㄽ⦅ࠊ᪥ᮏ┳ㆤ༠఍ฟ∧఍ ࠊ⥲࣮࣌ࢪ ࠊ㸫 ᯇ⏣༓᫓㸦ศᢸᇳ➹㸧 ᅾᏯேᕤ࿧྾⒪ἲࠊ➨ 4 ∧ᐙ᪘┳ㆤࢆᇶ┙࡜ࡋࡓᅾᏯ┳ㆤㄽ㸰ᐇ

㊶⦅㸬᪥ᮏ┳ㆤ༠఍ฟ∧఍ ࠊ⥲࣮࣌ࢪ ࠊ㸫 ᯇ⏣༓᫓㸦ศᢸᇳ➹㸧 ṑ⛉ཱྀ࣭⭍⾨⏕ࠊ⚄⚄⤒㞴⑓㡿ᇦࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᐇ㊶࢔ࣉ࣮ࣟࢳ ᨵゞ➨  ∧ ࠊ⥲࣮࣌ࢪ ࠊ㸫,, Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ  ௳㸧ཎཱྀ㐨Ꮚ ࢩ࣏ࣥࢪ࣒࢘ ᐇ㊶࡜◊✲ࡢࢥ࣮ࣛ࣎ࣞࢩࣙࣥ̿ᅾᏯ┳ㆤࡢᮍ᮶ࢆᣅࡃ㸫➨  ᅇ᪥ᮏᅾᏯ┳ㆤᏛ఍Ꮫ⾡㞟఍  㟼ᒸ┴㸦ᣍ⪸㸧

－ 105 －

2.

୰ᒣඃᏘ ࢩ࣏ࣥࢪ࣒࢘ NPPV ࢣ࢔㝔ෆ࠿ࡽᅾᏯࡲ࡛ ከ⫋✀ࡀ㛵ࢃࡾࠊ⚾ࡓࡕࡣࡇࢇ
࡞᪉ἲ࡛ࡸࡗ࡚ࡲࡍࠋᅾᏯ NPPV ࢣ࢔ࢩࢫࢸ࣒సࡾ࡟࠾ࡅࡿ㞴⑓┳ㆤࡢྲྀࡾ⤌ࡳࠋ➨ 40ᅇ᪥ᮏ࿧྾⒪ἲ་Ꮫ఍Ꮫ⾡㞟఍ 2018.8.4 ᮾிࢻ࣮࣒࣍ࢸࣝ ᮾி㒔㸦ᣍ⪸㸧

3.

୰ᒣඃᏘ ≉ูㅮ₇㸸ᅾᏯ࠿ࡽࡢᣢࡕ㎸ࡳ་⒪ᶵჾ࡟㛵ࡍࡿ࢖ࣥࢩࢹࣥࢺ ➨ 5 ᅇ᪥ᮏ་⒪Ᏻ඲Ꮫ఍Ꮫ⾡㞟఍ 2019.2.10 ᮾி኱Ꮫ ᮾி㒔㸦ᣍ⪸㸧ࡑࡢ௚ 㸦ィ 19 ௳㸧⮬⏤ᥖ㍕
1.

ཎཱྀ㐨Ꮚࠊ➟ཎᗣ௦ࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊ ┳ㆤ⫋࡜௓ㆤ⫋㐃ᦠ࡟ࡼ
ࡿᅾᏯ⒪㣴ᨭ᥼ࣜࢫࢡ⟶⌮ࢶ࣮ࣝࡢ㛤Ⓨ ➨ 5 ᅇ᪥ᮏ་⒪Ᏻ඲Ꮫ఍Ꮫ⾡㞟఍ 2019.2.10ᮾி㒔ᩥி༊

2.

Cazzolli PA, NakayamaY, Brooks BR, Lewarski J, McKim D, Chatburn R. Survival and Outcomesof 122 Patients with ALS/MND Using Tracheostomy Ventilation (TV). 29 th International
Symposium on ALS/MND, Glasgow, UK, 2018.12.9

3.

NakayamaY, Cazolli PA, Matsuda C, Haraguchi1 M, Hayashi K, Bokuda K, Shimizu T. Comparing
Outcomes of Patients with Amyotrophic Lateral Sclerosis (ALS) Using Tracheostomy Invasive
Ventilation (TIV) in Tokyo, Japan and Ohio, USA. 29 th International Symposium on ALS/MND,
Glasgow, UK, 2018.12.8

4.

Bokuda K, Shimizu T, Morishima R, Kimura H, Kamiyama T, Nakayama Y, Isozaki E. Differencesin size of EMG-detected fasciculation potentials between muscles with and without US-detectedfasciculations in ALS. 29 th International Symposium on ALS/MND, Glasgow, UK, 2018.12.7

5.

ᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊཎཱྀ㐨ᏊࠊΎỈಇኵ እ᮶㏻㝔୰ࡢ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ⯉ᅽ࡜⮫ᗋᣦᶆ࡜ࡢ㛵ಀ㸦ඃ⚽₇㢟㈹㸧 ➨ 36 ᅇ᪥ᮏ⚄⤒἞⒪Ꮫ఍⥲఍ 2018.11.23 ᮾி㒔

6.

ᯈᇉࡺࡳࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊࠊᐑཎ⯙ࠊᑠ᳃ဴኵ 㞴⑓ᝈ⪅⏕άᐇែㄪᰝ 1.⤖ᯝᴫせ࡜඲⯡ࡢᨭ᥼ࢽ࣮ࢬ ➨ 6 ᅇ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ఍
2018.11.16 ᒸᒣ┴

7.

୰ᒣඃᏘࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊࠊᐑཎ⯙ࠊᑠ᳃ဴኵ 㞴⑓ᝈ⪅ࡢ⏕άᐇែㄪᰝ 2.㞴⑓ἲ᪋⾜ᚋࡢ㞴⑓ࡢ㢮ᆺ໬ࡢヨࡳ ➨ 6 ᅇ᪥ᮏ㞴⑓་⒪ࢿࢵࢺ࣮࣡ࢡᏛ
఍ 2018.11.16 ᒸᒣ┴

8.

୰ᒣඃᏘࠊཎཱྀ㐨Ꮚࠊட஭ᬛᏊ ALS ᝈ⪅ࡢࢸࣞࢼ࣮ࢩࣥࢢ࡟࠾ࡅࡿ᪥ࠎࡢయㄪỴᐃせᅉ➨ 28 ᅇ᪥ᮏ࿧྾ࢣ࢔ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍ vol26.suppls

9.

2018.11.9 ༓ⴥ┴ΎỈಇኵࠊᮌ⏣⪔ኴࠊ᳃ᓥுࠊୖᒣຮࠊᮌᮧⱥ⣖ࠊ୰ᒣඃᏘࠊᕝ⏣᫂ᗈࠊ♒ᓮⱥ἞ࠊᏱᕝ⩏୍ ➽ⴎ⦰ᛶഃ⣴◳໬⑕࡟࠾ࡅࡿయᛶឤぬㄏⓎ㟁఩࡜⏕࿨ணᚋࡢ㛵㐃㸸Ⓨ⑕㒊఩࡟ࡼࡿ᳨ウ ➨ 48 ᅇ᪥ᮏ⮫ᗋ⚄⤒⏕⌮Ꮫ఍Ꮫ⾡኱఍ࠊ ⮫ᗋ⚄⤒⏕⌮Ꮫ 46(5)ࠊ509ࠊ 2018.11.9

10. ΎỈಇኵࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊཎཱྀ㐨Ꮚࠊᯘ೺ኴ㑻ࠊᮌ⏣⪔ኴ ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢデ᩿ᚋࡢయ㔜⟶⌮ࡣ⏕࿨ணᚋࢆᨵၿࡍࡿ ➨ 14 ᅇ᪥ᮏ⚄⤒➽⑌ᝈᦤ㣗࣭ᄟୗ࣭ᰤ㣴◊✲఍ 2018.10.27 ឡ▱┴ྡྂᒇᕷ
11. ཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᑠ಴ᮁᏊ ᅾᏯ⒪㣴ᨭ᥼࡟࠾ࡅࡿ┳ㆤ⫋࡜௓ㆤ⫋ࡢ㐃ᦠᚓⅬࡢᕪ࡟ᙳ㡪ࡍࡿせᅉ̿㐃ᦠࡢ㉁ᣦᶆ࡟ࡼࡿศᯒ̿ ➨ 22 ᅇ᪥ᮏ┳ㆤ⟶⌮Ꮫ఍ࡀᏛ⾡㞟఍ 2018.8.25 රᗜ┴⚄ᡞᕷ12. ཎཱྀ㐨Ꮚࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊ 㞴⑓ࡢࢣ࢔࣐ࢿࢪ࣓ࣥࢺ࡟㛵ࡍࡿ
ᐇ㊶▱ࡢ㉁ⓗศᯒ. ➨ 23 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ 23(1).65 2018.7.22－ 106 －

13. ᑠ಴ᮁᏊࠊ኱➉ᩄஅࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊᯈᇉࡺࡳࠊ୰ᒣඃᏘ ࢫࣔࣥ⒪㣴⪅ࡢ㌟య⑕≧࡜⏕ά≧ἣ࡟㛵ࡍࡿ᳨ウ-᳨デཷデ⪅ 3 ౛ࡢศᯒ-. ➨ 23 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍.23(1).46
2018.7.22
14. ᯇ⏣༓᫓ࠊ୰ᒣඃᏘࠊ㇂ཱྀ⌔ᐇࠊཎཱྀ㐨Ꮚࠊ⏦னᐃࠊ஬༑ᔒ㞷ᜨࠊᯈᇉࡺࡳࠊᑠ಴ᮁᏊࠊ
㇂ཱྀு୍ࠊᕝ⏣᫂ᗈ እ᮶㏻㝔୰ࡢ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ SEIQoL㸫DW ࡢ≉ᚩ ➨ 23ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ 23(1).31. 2018.7.21
15. ᑠ಴ᮁᏊࠊᯈᇉࡺࡳࠊཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ୰ᒣඃᏘ ᅾᏯ㞴⑓ᝈ⪅ࡢデ⒪࣭┳ㆤࡢ฼⏝࡟࠿࠿ࡿㄢ㢟ᢳฟࡢࡓࡵࡢࠕ㞴⑓ࡢᆅᇦデ᩿ࢶ࣮ࣝࠖ ➨ 23 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ 23(1).37.
2018.7.21
16. ཎཱྀ㐨Ꮚࠊᯇ⏣༓᫓ࠊ୰ᒣඃᏘ ➽ⴎ⦰ᛶഃ⣴◳໬⑕⒪㣴⪅ࡢእ᮶ᨭ᥼࡟࠾ࡅࡿಖ೺ᡤಖ
೺ᖌ࡜ࡢ㐃ᦠ. ➨ 12 ᅇ᪥ᮏ៏ᛶ┳ㆤᏛ఍Ꮫ⾡㞟఍ 2018.7.15 ᮾி㒔ရᕝ17. ᯇ⏣༓᫓ࠊΎỈಇኵࠊ୰ᒣඃᏘࠊཎཱྀ㐨Ꮚ ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢ Cough Peak Flownࡢపୗ⋡ࡣ⏕࿨ணᚋணᅉᏊ࡛࠶ࡿ ➨ 59 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2018.5.26 ໭ᾏ㐨ᮐᖠᕷ
18. ୰ᒣඃᏘ ALS ࡟࠾࠸࡚౵くⓗ࿧྾⿵ຓ㛤ጞࡲ࡛ࡢయ㔜ῶᑡ⋡ࡣ㐍⾜ணᅉᏊ࡜࡞ࡾ࠺

ࡿ࠿㸽㸦࣓ࢹ࢕࢝ࣝࢭࢵࢩ࣭ࣙࣥඃ⚽₇㢟㸧➨ 59 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2018.5.26 ໭ᾏ㐨ᮐᖠᕷ
19. ΎỈಇኵࠊᮌ⏣⪔ኴࠊ୰ᒣඃᏘࠊᯇ⏣༓᫓ࠊཎཱྀ㐨Ꮚࠊᕝ⏣᫂ᗈࠊ☾ᓮⱥ἞ ➽ⴎ⦰ᛶഃ⣴◳໬⑕ᝈ⪅ࡢデ᩿ᚋࡢయ㔜ῶᑡࡣࠊ⏕࿨ணᚋࢆண

ࡍࡿ࠿㸽 ➨ 59 ᅇ᪥ᮏ⚄⤒Ꮫ఍Ꮫ⾡኱఍ 2018.5.23 ໭ᾏ㐨ᮐᖠᕷ
III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 40 ௳㸧
1.

୰ ᒣ ඃ Ꮨ  HMV ゼ ၥ ┳ ㆤ ࡢ ᐇ 㝿  ᖹ ᡂ 30 ᖺ ᗘ ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ࡟ 㛵 ࡍ ࡿ ㅮ ⩦ ఍
2019..3.17 ኱㜰ᗓ

2.

୰ᒣඃᏘ

HMV ゼ ၥ ┳ ㆤ ࡢ ᐇ 㝿  ᖹ ᡂ 30 ᖺ ᗘ ᅾ Ꮿ ே ᕤ ࿧ ྾ ჾ ࡟ 㛵 ࡍ ࡿ ㅮ ⩦ ఍

2019.2.26 ᮾி㒔኱⏣༊
3.

ཎཱྀ㐨Ꮚ ᪥ᖖࡢ㛵ࢃࡾ࡛ឤࡌࡿࡶࡸࡶࡸࢆ೔⌮ⓗഃ㠃࠿ࡽ⪃࠼࡚ࡳࡼ࠺ ᖹᡂ 30 ᖺᗘ
ᅾᏯ⒪㣴ࢆᨭ࠼ࡿ་⒪⪅ࡢ㐃⤡఍ 2019.2.18 㒔❧⚄⤒⑓㝔 ᮾி㒔ᗓ୰ᕷ

4.

ཎཱྀ㐨Ꮚ ⚄⤒㞴⑓ࡢ௦⾲ⓗ⑌ᝈࡢ≉ᚩ࡜⒪㣴ୖࡢ࣏࢖ࣥࢺ 㞴⑓ᝈ⪅⒪㣴ᨭ᥼஦ᴗㅮ
₇఍㸦ㅮᖌ㸧 2019.1.28 ᮾி㒔ከᦶᗓ୰ಖ೺ᡤ ᮾி㒔ᗓ୰ᕷ

5.

୰ᒣඃᏘ ⥔ᣢᏳᐃᮇࡢ┳ㆤ࣭⚄⤒⑓㝔බ㛤ㅮᗙ 2019.1.16 ᮾி㒔6.

୰ᒣඃᏘ ALS ࡢ⒪㣴⾜⛬࡜ࡑࡢ┳ㆤ㹼ಖ೺ᖌࡢᙺ๭㹼 2018.12.21 ῰㇂༊ಖ೺ᡤ ᮾி㒔7.

ཎཱྀ㐨Ꮚ 㡿ᇦࡢ␗࡞ࡿከ⫋✀㐃ᦠ࡟ࡼࡿᅾᏯ་⒪࣭௓ㆤ㐃ᦠ᥎㐍஦ᴗ 㞴⑓ㅮ₇఍㸦ㅮᖌ㸧 2018.12.15 㟼ᒸ┴὾ᯇᕷ

8.

୰ᒣඃᏘ ࠙┳ㆤᐇ㊶ղࠚ4㸬⏕άሙ㠃࣭≧ἣูᨭ᥼ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ  2018.12.2 ᮾி㒔኱⏣༊9.

୰ᒣඃᏘ ࠙┳ㆤᐇ㊶ࠚ₇⩦ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ2018.12.1 ᮾி㒔኱⏣༊

10. ཎཱྀ㐨Ꮚ ࠙ᇶ♏⛉┠ࠚ㞴⑓ไᗘࡢ⌧≧ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ㅮᖌ 2018.12.1 ᮾி㒔኱⏣༊

－ 107 －

11. ཎཱྀ㐨Ꮚ ࠙┳ㆤᐇ㊶ࠚ₇⩦ ➨ 5 ᅇ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃ◊ಟ఍ ࣇ࢓ࢩࣜࢸ࣮ࢱ࣮ 2018.12.1 ᮾி㒔኱⏣༊
12. ᯇ⏣༓᫓ ᪥ᮏ㞴⑓┳ㆤᏛ఍Ꮫ఍ㄆᐃ㞴⑓┳ㆤᖌㄆᐃไᗘ ㄆᐃ◊ಟ఍ㅮᖌ 2018.12.1
ᮾி㒔ᩥி༊
13. ཎཱྀ㐨Ꮚ 㟼ᒸ┴♫఍⚟♴ேᮦࢭࣥࢱ࣮ࠕᖹᡂ 30 ᖺᗘ⚟♴⫋ဨࡢࡓࡵࡢࣄࣖࣜࣁࢵࢺ࣭
࢔ࢡࢩࢹࣥࢺࢭ࣑ࢼ࣮ࠖ
㸦ㅮᖌ㸧 2018.11.22 㟼ᒸ┴㟼ᒸᕷ
14. ᑠ಴ᮁᏊ ᒸᒣ┴㞴⑓◊ಟ఍ᣦᐃⓎゝࢸ࣮࣐ࠕ㇦㞵⅏ᐖ࡜ᆅᇦᨭ᥼ࢿࢵࢺ࣮࣡ࢡࠖ
2018.11.22 ᒸᒣ┴
15. ཎཱྀ㐨Ꮚ ⚄⤒㞴⑓┳ㆤ◊ಟࠕ⑓ึᮇ࣭㐍⾜ᮇࡢ┳ㆤࠖࠕពᛮỴᐃᨭ᥼࡜೔⌮ࠖ㸦ㅮᖌ㸧
2018.11.16 ᮾி㒔❧⚄⤒⑓㝔 ᮾி㒔ᗓ୰ᕷ
16. ୰ᒣඃᏘ 㞴⑓ᝈ⪅ࡢ⌮ゎ࡜ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ ᖹᡂ 30 ᖺᗘᒣ᲍┴ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐
ࢿ࣮ࢪ࣮ࣕ㣴ᡂ◊ಟ఍ 2018.11.1 ᒣ᲍┴⏥ᗓᕷ17. ཎཱྀ㐨Ꮚ ᒣ᲍┴┳ㆤ༠఍ࢺ࣮ࢱࣝࢧ࣏࣮ࢺ࣐ࢿࢪ࣮ࣕ◊ಟࠕ⚄⤒㞴⑓┳ㆤࠖ㸦ㅮᖌ㸧
2018.11.1 ᒣ᲍┴⏥ᗓᕷ18. ᯇ⏣༓᫓ ➨ 30 ᖺᗘ➨ 2 ᅇᅾᏯ⒪㣴ࢆᨭ࠼ࡿ་⒪⪅ࡢ㐃⤡఍ㅮᖌ 2018.10.29 ᮾி㒔❧⚄⤒⑓㝔 ᮾி㒔ᗓ୰ᕷ19. ୰ᒣඃᏘ ⚄⤒㞴⑓⒪㣴⪅࡟࠾ࡅࡿẼ㐨ࢣ࢔࡜ᅾᏯ⏝་⒪ᶵჾࡢᏳ඲⟶⌮ ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟᛂ⏝ࢥ࣮ࢫ 2018.10.25 ᮾி㒔ୡ⏣㇂༊
20. ᯇ⏣༓᫓ 㞴⑓ᝈ⪅⒪㣴ᨭ᥼஦ᴗㅮ₇఍㞴⑓⒪㣴ᨭ᥼஦ᴗ࡟࠾ࡅࡿㅮ₇఍࣭஺ὶ఍࡟࠾ࡅ
ࡿㅮᖌ࣭ྖ఍࣭ຓゝ 2018.10.24 ᮾி㒔❧⚄⤒⑓㝔 ᮾி㒔ᗓ୰ᕷ21. ୰ᒣඃᏘ ┳ㆤᏛ≉ูㅮ⩏࣭⚄⤒⤒㞴⑓⒪㣴⪅࡜ᐙ᪘ࢆ୰ᚰ࡜ࡋࡓࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥᨭ
᥼.㟼ᒸ┴❧኱Ꮫ 2018.10.16 㟼ᒸ┴㟼ᒸᕷ
22. ཎཱྀ㐨Ꮚ ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟࠕ㞴⑓┳ㆤ஦౛᳨ウ ⚄⤒㞴⑓ゼၥ┳ㆤࡢ┳ㆤ㐣⛬ࠖ㸦ㅮᖌ㸧 2018.10.16 ᮾி㒔ୡ⏣㇂༊
23. ᯇ⏣༓᫓ ಖ೺ᖌࢆᑐ㇟࡜ࡋࡓࠕALS ࡢ࿧྾㞀ᐖࡢᨭ᥼ࡢ࣏࢖ࣥࢺࠖࡢㅮ⩏ㅮᖌ
2018.10.11 ᮾி㒔ከᦶ❧ᕝಖ೺ᡤ ᮾி㒔❧ᕝᕷ
24. ୰ᒣඃᏘ 㛗ᮇẼ⟶ษ㛤ேᕤ࿧྾⒪㣴⪅ࡢ⤒㐣࠿ࡽᏛࢇࡔࡇ࡜ ྜే⑕࣭㠀㐠ື⑕≧ࡢฟ⌧ഴྥ࡜៏ᛶᮇேᕤ࿧྾ࢣ࢔ ⚄⤒ࣜࣁࣅࣜ◊ಟ఍ 2018.10.4 㒔❧⚄⤒⑓㝔 ᮾி㒔ᗓ୰ᕷ
25. ᑠ಴ᮁᏊ Ụᡞᕝ༊⅏ᐖ᫬ಶูᨭ᥼ィ⏬࡟㛵ࡍࡿ◊ಟ ࢸ࣮࣐ࠕᅾᏯ㞴⑓ᝈ⪅ࡢ⅏ᐖ஭ಶูᨭ᥼ィ⏬⟇ᐃࠖ㸦ㅮᖌ㸧 2018.9.14 ᮾி㒔Ụᡞᕝ༊
26. ᯇ⏣༓᫓ ᅾᏯ㞴⑓ᝈ⪅⒪㣴ᨭ᥼஦ᴗ࡟࠾ࡅࡿࠕ⅏ᐖ᫬ಶูᨭ᥼ィ⏬ࡢ⟇ᐃࠖࡢຮᙉ఍ㅮ
ᖌ 2018.9.11 ᮾி㒔ከᦶ❧ᕝಖ೺ᡤ ᮾி㒔❧ᕝᕷ
27. ᯇ⏣༓᫓ බ┈㈈ᅋἲேᮾி㒔┳ㆤ༠఍࣭ゼၥ┳ㆤᖌࡢ㞴⑓┳ㆤ࡟㛵ࡍࡿ◊ಟ఍ㅮᖌ
2018.9.4 ᮾி㒔᪂ᐟ༊28. ୰ᒣඃᏘ 㞴⑓ᝈ⪅ࡢ┳ㆤ ゼၥ┳ㆤㄆᐃ┳ㆤᖌ◊ಟ ឡ▱┴┳ㆤ༠఍ 2018.8.25 ឡ▱┴ྡྂᒇᕷ
29. ཎཱྀ㐨Ꮚ ࢣ࢔ࢧ࣏࣮ࢺࣔࣔ ࣊ࣝࣃ࣮ࢫ࢟ࣝ࢔ࢵࣉ◊ಟ㸦ㅮᖌ㸧2018.7.29 ᮾி㒔᪂ᐟ༊
30. ୰ᒣඃᏘ ேᕤ࿧྾ჾ࡟ࡘ࠸࡚ࡢᏛ⩦఍ ゼၥ┳ㆤࢫࢸ࣮ࢩࣙࣥⰱⰼ 2018.7.25 ᮾி㒔
31. ୰ᒣඃᏘ ึᮇ࠿ࡽࡣࡌࡵࡿ࿧྾ࢣ࢔ ⫵ࢆᰂࡽ࠿ࡃಖࡘ࡟ࡣ㸽㹼⫵ᐜ㔞ࣜࢡ࣮ࣝࢺ࣓
ࣥࢺ㸦LVR㸸Lung Volume Recruitment㸧࡟ࡼࡿ࢚࢔ࢫࢱࢵ࢟ࣥࢢ㸦ᜥࡓࡵ㸧࡜တࡢ᭱኱ὶ

－ 108 －

㏿ࢆಖࡘ┳ㆤᐇ㊶ࡢ᥎㐍 ᪥ᮏ㞴⑓┳ㆤᏛ఍ࣉࣞࢭ࣑ࢼ࣮ 2018.7.20
32. ᯇ⏣༓᫓ ᅾᏯேᕤ࿧྾ჾ౑⏝⪅ࡢ⒪㣴ᨭ᥼ࠖࢆࢸ࣮࣐࡜ࡋࡓㅮ⩏ㅮᖌ 2018.7.18 ᮾி㒔ከᦶᑠᖹಖ೺ᡤ ᮾி㒔ᑠᖹᕷ33. ᑠ಴ᮁᏊ ᅾᏯ⒪㣴ᨭ᥼ィ⏬⟇ᐃホ౯ጤဨ఍ᇶㄪㅮ₇ ᅾᏯ㞴⑓ᝈ⪅ࡢ⅏ᐖ᫬ಶูᨭ᥼
ィ⏬ࡢ⟇ᐃ࡜ಖ೺άື 2018.7.2 ⏫⏣ᕷಖ೺ᡤ ᮾி㒔⏫⏣ᕷ
34. ୰ᒣඃᏘ ᫛࿴࣭ᖹᡂࡢᅾᏯேᕤ࿧྾⒪ἲᐇ㊶࠿ࡽࡇࢀ࠿ࡽࡢ࿧྾ࢣ࢔࡬ ᕝᓮ࿧྾ࢣ࢔
ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ◊✲఍ 2018.6.30 ⚄ዉᕝ┴ᕝᓮᕷ
35. ᯇ⏣༓᫓ ་⒪ᶵჾ㈚୚ゼၥ┳ㆤᖌ㐃⤡఍་⒪ᶵჾ㈚୚ゼၥ┳ㆤᖌ㐃⤡఍࡛ࡢຓゝ
2018.6.27 ᮾி㒔ከᦶᗓ୰ಖ೺ᡤ ᮾி㒔ᗓ୰ᕷ
36. ཎཱྀ㐨Ꮚ ᮾி㒔ᅾᏯ㞴⑓ᝈ⪅ゼၥ┳ㆤᖌ➼㣴ᡂ◊ಟࠕᅾᏯ⒪㣴࡟࠾ࡅࡿࣜࢫࢡ࣐ࢿࢪ࣓
ࣥࢺࠖ㸦ㅮᖌ㸧 2018.6.21 ᮾி㒔᪂ᐟ༊37. ୰ᒣඃᏘ ⚄⤒㞴⑓⒪㣴⪅ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥᨭ᥼࣭ᖹᡂ 30 ᖺᗘᅾᏯேᕤ࿧྾ᝈ⪅ゼၥ┳ㆤᖌ㣴ᡂ◊ಟᇶ♏ࢥ࣮ࢫ㸦ㅮ⩏㸧 2018.6.13 ᮾி㒔ᩥி༊38. ᯇ⏣༓᫓ ᰴᘧ఍♫࢔ࣉࣞ௓ㆤࢧ࣮ࣅࢫ 㞴⑓ᝈ⪅࡟ᑐࡍࡿཱྀ⭍ࢣ࢔ࡢ࣏࢖ࣥࢺ࡜ຠᯝ
࡟㛵ࡍࡿ◊ಟ఍ㅮᖌ 2018.6.11 ᮾி㒔Ṋⶶ㔝ᕷ
39. ᯇ⏣༓᫓ ᅾᏯ⒪㣴ᨭ᥼ィ⏬⟇ᐃ࣭ホ౯ጤဨ఍⚄⤒㞴⑓ᝈ⪅ࡢ࿧྾ჾ⟶⌮࡟㛵ࡍࡿ◊ಟ఍
ㅮᖌ 2018.5.30 ᮾி㒔ከᦶᗓ୰ಖ೺ᡤ ᮾி㒔ᗓ୰ᕷ40. ᯇ⏣༓᫓ ᖹᡂ 30 ᖺ᪂᥇⏝┳ㆤᖌ࡟ᑐࡍࡿࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡟㛵ࡍࡿ◊ಟ఍ㅮᖌ
2018.5.21 ᅜ❧⑓㝔ᶵᵓ⟽᰿⑓㝔 ⚄ዉᕝ┴ᑠ⏣ཎᕷIV. ≉グ஦㡯
࠙ཷ㈹ࠚ
1.

୰ᒣඃᏘ ➨ 59 ᅇ᪥ᮏ⚄⤒Ꮫ఍⥲఍࣓ࢹ࢕࢝ࣝࢫࢱࢵࣇඃ⚽₇㢟㈹2.

ᯇ⏣༓᫓ ➨ 36 ᅇ᪥ᮏ⚄⤒἞⒪Ꮫ఍࣓ࢹ࢕࢝ࣝࢫࢱࢵࣇඃ⚽₇㢟㈹3.

ཎཱྀ㐨Ꮚ ➨ 5 ᅇ᪥ᮏ་⒪Ᏻ඲Ꮫ఍Ꮫ⾡㞟఍࣌࢖ࢩ࢙ࣥࢺࢭ࣮ࣇࢸ࢕࣮ࣇ࢓࣮ࢫࢺ㈹

࠙ࡑࡢ௚ࠚ
1.

୰ᒣඃᏘ ᪥ᮏ㞴⑓┳ㆤᏛ఍ㄆᐃ┳ㆤᖌㄆᐃጤဨ఍ጤဨ㛗

2.

୰ᒣඃᏘ ᮾி㒔㞴⑓ᆅᇦᑐ⟇༠㆟఍ጤဨࠊᮾி㒔⑌⑓ᑐ⟇㒊఍ጤဨࠊᖹᡂ 30 ᖺᗘᮾி㒔⚟♴ಖ೺ᇶ♏ㄪᰝ᳨ウ఍ጤဨ

3.

୰ᒣඃᏘ ᮾி་⛉ṑ⛉኱Ꮫࠊᖇி⛉Ꮫ኱Ꮫ 㠀ᖖ໅ㅮᖌ4.

ཎཱྀ㐨Ꮚ ௓ㆤ⚟♴ኈᅜᐙヨ㦂 ヨ㦂ጤဨ5.

ཎཱྀ㐨Ꮚ ཌ⏕ປാ┬ ⪁ேಖ೺೺ᗣቑ㐍➼஦ᴗࠕ௓ㆤ⫋࡟࠾ࡅࡿၻ⑱྾ᘬ➼ࡢ㉁ࡢ☜ಖ࡟㛵ࡍࡿㄪᰝ◊✲஦ᴗࠖᗙ㛗6.

ཎཱྀ㐨Ꮚ ཌ⏕ປാ┬ࠕ௓ㆤᨭ᥼ᑓ㛛ဨ◊ಟᨵၿ࡟ಀࡿㄪᰝ➼୍ᘧ஦ᴗࠖ◊ಟྥୖጤဨ఍
࣮࣡࢟ࣥࢢጤဨ

7.

ᑠ಴ᮁᏊ Ⲉᇛ࢟ࣜࢫࢺᩍ኱ᏛࠊṊⶶ㔝኱Ꮫ 㠀ᖖ໅ㅮᖌ－ 109 －

ࣉࣟࢪ࢙ࢡࢺྡ

⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࣉࣟࢪ࢙ࢡࢺ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 10 ௳㸧
1.

Makino E, Nakamura N, Miyabe M, Ito M, Kanada S, Hata M, Saiki T, Sango K, Kamiya H, Nakamura
J, Miyazawa K, Goto S, Matsubara T, Naruse K. Conditioned media from dental pulp stem cells
improved diabetic polyneuropathy via anti-inflammatory, neuroprotective and angiogenic actions:cell-free regenerative medicine for diabetic polyneuropathy. J Diabetes Investig 2019 Mar 20.

2.

Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S,
Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M,
Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi
A, Yoshimori T. Suppression of autophagic activity by Rubicon is a signature of aging. Nat Commun
10:847 (2019)3.

Tatsumi Y, Matsumoto N, Iibe N, Watanabe N, Torii T, Sango K, Homma K, Miyamoto Y, Sakaguchi
H, Yamauchi J. CMT type 2N disease-associated AARS mutant inhibits neurite outgrowth that canbe reversed by valproic acid. Neurosci Res 139:69-78 (2019)4.

Tatsumi Y, Kato A, Mano M, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakamura J, Kato
K. Omega-3 polyunsaturated fatty acids exert antioxidant effects through the Nrf2 pathway in theimmortalized mouse Schwann IMS32 Cells. J Diabetes Investig 10:602-612 (2019)5.

Kato A, Tatsumi Y, Yako H, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakmura J, Kato K.
Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative stress via the
ER stress response in immortalized adult mouse Schwann cells. Neurosci Res 2018 Nov 13.

6.

Moriwaki Y, Ohno Y, Ishii T, Takamura Y, Kita Y, Watabe K, Sango K, Tsuji S, Misawa H. SIMPLE
binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in thetrans-Golgi network and/or recycling endosomes. PLoS One 13:e0199829 (2018)7.

Takaku S, Yako H, Niimi N, Akamine T, Kawanami D, Utsunomiya K, Sango K. Establishment ofa myelinating co-culture system with a motor neuron-like cell line NSC-34 and an adult rat Schwann
cell line IFRS1. Histochem Cell Biol 149:537-543 (2018)8.

Yoshida S, Hasegawa T, Suzuki M, Sugeno N, Kobayashi J, Ueyama M, Fukuda M, Ido-Fujibayashi
A, Sekiguchi K, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M. Parkinson's
disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity throughperturbation of endosomal trafficking. Hum Mol Genet 27:823-836 (2018)

9.

Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami
H, Yagihashi S, Chung SK, Sango K. A spontaneously immortalized Schwann cell line from aldose
reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism. J
Neurochem 144:710-722 (2018)

10. Tsukada T, Yoshida S, Kito K, Fujiwara K, Yako H, Horiguchi K, Isowa Y, Yashiro T, Kato T, Kato
Y, TGFȕ signaling reinforces pericyte properties of the non-endocrine mouse pituitary cell line
TtT/GF. Cell Tissue Res 371:339-350 (2018)－ 110 －

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 5 ௳㸧
1.

Niimi N, Yako H, Takaku S, Sango K. Chapter 2: Pathogenetic mechanisms of amiodarone-induced
peripheral neuropathy. Advances in Medicine and Biology 136:41-62 (2019).

2.

Niimi N, Sango K. Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the
study of axonal degeneration and regeneration. Neural Regen Res 13:979-980 (2018)3.

Suzuki M, Sango K, Wada K, Nagai Y. Pathological role of lipid interaction with Į-synuclein in
Parkinson's disease. Neurochem Int 119:97-106 (2018)4.

୕஬୍᠇ࠊ᪂ぢ┤ᏊࠊඵᏊⱥྖ. ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓ែ, ⢾ᒀ⑓἞⒪ࡢࢽ࣮ࣗࣃࣛࢲ࢖
࣒ ➨ 4 ᕳࠕ⢾ᒀ⑓࡟ྜేࡍࡿ⑓ែ࡜ࡑࡢ἞⒪ࠖ㸦ຍ᮶ᾈᖹ⦅㸧, ་⸆ࢪ࣮ࣕࢼࣝ♫, ኱㜰,
169-176 (2019)5.

኱ሙᰟᶞࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ. ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ RubiconࡢⓎ⌧ᢚไࡣ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ⚄⤒⑕≧ࢆᨵၿࡉࡏࡿ. ᪥ᮏ⑓ែ⏕⌮Ꮫ఍㞧ㄅ, 27:28-32 (2018)

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 6 ௳㸧1.

㕥ᮌ࣐ࣜ. ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⚄⤒ኚᛶ⑌ᝈ◊✲. ➨ 789 ᅇ஑ᕞ኱Ꮫ⏕య㜵ᚚ་Ꮫ◊✲ᡤࢭ࣑ࢼ࣮. 2019.3.4, ⚟ᒸ┴⚟ᒸᕷ.

2.

୕஬୍᠇. ⣽⬊⏕≀Ꮫ࠿ࡽぢࡓ⢾ᒀ⑓⚄⤒㞀ᐖ㸫⑓ែ௦ㅰࢆ୰ᚰ࡟㸫. ➨ 53 ᅇ⢾ᒀ⑓Ꮫࡢ㐍Ṍࢩ࣏ࣥࢪ࣒࢘ࠕ⢾ᒀ⑓⚄⤒㞀ᐖࡢ௒࡜ᮍ᮶ࠖ. 2019.3.2, 㟷᳃┴㟷᳃ᕷ.

3.

୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ. ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓ែ⏕≀Ꮫ㸫⣽⬊࠿ࡽಶయ࡬㸫. ➨ 33 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ࠕ⚄⤒㞀ᐖࡢ᭱㏆ࡢ㐍Ṍ࡜ㄢ㢟ࠖ. 2018.10.20, ᮾி㒔༓௦⏣༊.

4.

᪂ぢ┤Ꮚࠊ୕஬୍᠇. ௦ㅰ␗ᖖ࡟క࠺⚄⤒෌⏕㞀ᐖࡢゎᯒ㸫ࢩࣗ࣡ࣥ⣽⬊ᰴࡢ᭷⏝ᛶ㸫.
➨ 29 ᅇ᪥ᮏᮎᲈ⚄⤒Ꮫ఍Ꮫ⾡㞟఍ࢩ࣏ࣥࢪ࣒࢘ࠕᮎᲈ⚄⤒ᦆയ἞⒪ࡢㄢ㢟࡜ᑗ᮶ᒎᮃ㸸⚄⤒෌⏕࣓࢝ࢽࢬ࣒ࡢほⅬ࠿ࡽࠖ. 2018.9.8, ᒣཱྀ┴ୗ㛵ᕷ.

5.

୕஬୍᠇. ᚠ⎔་Ꮫ࡟㛵㐃ࡋࡓࢽ࣮ࣗࣟࣃࢳ࣮ࡢ⑓ែ⏕⌮. ➨ 28 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ࢩ࣏ࣥࢪ࣒࢘ࠕ」║ⓗᛮ⪃࡛ᚠ⎔࡟࢔ࣉ࣮ࣟࢳࡍࡿࠖ. 2018.8.4, ⚄ዉᕝ┴ᶓ὾ᕷ.

6.

Sango K, Takaku S, Tsukamoto M, Akamine T, Niimi N, Yako H, Kawanami D, Utsunomiya K.
Establishment of co-culture systems with lined neurons and Schwann cells for the study ofdemyelinating neuropathies. ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ࢩ࣏ࣥࢪ࣒࢘ࠕືⓗ࡞࣑࢚ࣜࣥ㸦㧊㠧㸧ࠊࡑࡢ◊✲ࡣ⚄⤒⑌ᝈ἞⒪ࡢ᪂ࡓ࡞ᡭ᥃࠿ࡾࢆᥦ౪ࡍࡿࠖ2018.7.28, රᗜ┴⚄ᡞᕷ.

ࡑࡢ௚ 㸦ィ 24 ௳㸧⮬⏤ᥖ㍕
1.

Sango K, Takaku S, Tsukamoto M, Niimi N, Yako H. Exendin-4 promotes myelination in a coculture of dorsal root ganglion neurons and immortalized Schwann cells IFRS1. ➨ 96 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍㸦࢔ࢪ࢔࣭࢜ࢭ࢔ࢽ࢔⏕⌮Ꮫ Congress㸧. 2019.3.30, රᗜ┴⚄ᡞᕷ.

2.

Yako H, Niimi N, Kato A, Takaku S, Kato K, Sango K. Tsukamoto M, Exogenous pyruvate maintains－ 111 －

glycolysis-TCA cycle flux in Schwann cells under the high glucose conditions. ➨ 96 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱఍㸦࢔ࢪ࢔࣭࢜ࢭ࢔ࢽ࢔⏕⌮Ꮫ Congress㸧. 2019.3.30, රᗜ┴⚄ᡞᕷ.
3.

୕஬୍᠇. ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢ⑓ែゎ᫂í㒔་Ꮫ◊࡟࠾ࡅࡿ◊✲࣭ᗈሗάືࡢᐇ⦼࡜ㄢ㢟í. ➨ 56 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍㛵ᮾ⏥ಙ㉺ᆅ᪉఍. 2019.1.26, ⚄ዉᕝ┴ᶓ὾ᕷ.

4.

ඵᏊⱥྖࠊ᪂ぢ┤Ꮚࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇. እᅉᛶࣆࣝࣅࣥ㓟ࡣ㧗ࢢࣝࢥ࣮ࢫ⎔ቃୗ࡟࠾࠸࡚ࢩࣗ࣡ࣥ⣽⬊ᰴ IMS32 ࡢ࣑ࢺࢥࣥࢻࣜ࢔࿧྾࡜ ATP ⏘⏕ࢆ⥔
ᣢࡍࡿ. ➨ 18 ᅇ᪥ᮏ࣑ࢺࢥࣥࢻࣜ࢔Ꮫ఍. 2018.12.7, ⚟ᒸ┴ஂ␃⡿ᕷ.

5.

Sango K, Niimi N, Takaku S, Yako H, Mizukami H. Characterization of a spontaneously
immortalized Schwann cell line established from aldose reductase-deficient C57BL/6 mice. ➨ 23ᅇࢢࣜ࢔◊✲఍. 2018.12.1, ឡ▱┴ྡྂᒇᕷ.

6.

᪂ぢ┤ᏊࠊỈୖᾈဢࠊ୕஬୍᠇. 㧗ࢢࣝࢥ࣮ࢫ⎔ቃୗ࡟࠾ࡅࡿ࢔ࣝࢻ࣮ࢫ㑏ඖ㓝⣲Ḟᦆࢩࣗ࣡ࣥ⣽⬊ࡢ௦ㅰゎᯒ. ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍. 2018.11.29, ⚄ዉᕝ┴ᶓ὾ᕷ.

7.

㉥ᕊ཭௦ࠊ㧗ஂ㟼㤶ࠊ᪂ぢ┤ᏊࠊඵᏊⱥྖࠊ㕥ᮌ࣐ࣜࠊⓗሙᆂ୍㑻ࠊᕝᾉ኱἞ࠊᏱ㒔ᐑ୍඾ࠊ୕஬୍᠇. ࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄࢻࡣᑠ⬊యࢫࢺࣞࢫࢆ௓ࡋ࡚⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࡢⓎ⑕࣭㐍ᒎ࡟㛵୚ࡍࡿ. ➨ 33 ᅇ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍. 2018.10.20, ᮾி㒔༓௦⏣༊.

8.

ඵᏊⱥྖࠊ᪂ぢ┤Ꮚࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇. እᅉᛶࣆࣝࣅࣥ㓟ࡣ㧗ࢢࣝࢥ࣮ࢫ⎔ቃୗ࡛ IMS32 ⣽⬊ࡢゎ⢾⣔ࡢࣇࣛࢵࢡࢫࢆไᚚࡍࡿ. ➨ 33 ᅇ᪥ᮏ⢾ᒀ⑓ྜ
ే⑕Ꮫ఍. 2018.10.20, ᮾி㒔༓௦⏣༊.

9.

኱ሙᰟᶞࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ. ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ RubiconࡢⓎ⌧ᢚไ࡟ࡼࡿ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࡢ⑕≧ᨵၿ. ➨ 37 ᅇ᪥ᮏㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍㸬
2018.10.12, ໭ᾏ㐨ᮐᖠᕷ.

10. 㧗ஂ㟼㤶ࠊ୕஬୍᠇. ࢰࢽࢧ࣑ࢻࡣᡂ⇍ࣛࢵࢺᚋ᰿⚄⤒⠇ࢽ࣮ࣗࣟࣥࡢ⚄⤒✺㉳ఙ㛗ࢆಁ㐍ࡍࡿ. ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍. 2018.9.24, ி㒔ᗓி㒔ᕷ.
11. Akamine T, Takaku S, Niimi N, Matoba K, Yako H, Suzuki M, Kawanami D, Utsunomiya K, Sango
K. Involvement of endoplasmic reticulum stress in glycolaldehyde neurotoxicity: a novel
pathogenetic mechanism of diabetic neuropathy. Neurodiab2018, 2018.9.7, Rome, Italy.
12. Yako H, Niimi N, Kato A, Takaku S, Kato K, Sango K. Exogenous pyruvate as a critical molecule
for maintenance of glycolysis–tricarboxylic acid cycle in Schwann cells under high glucose
conditions. Neurodiab2018, 2018.9.5, Rome, Italy.
13. Sango K, Takaku S, Tsukamoto M, Akamine T, Saito M, Niimi N, Yako H, Matoba K, Kawanami
D, Utsunomiya K. Exendin-4 stimulates myelination in a co-culture of adult rat dorsal root ganglion
neurons and immortalized adult rat Schwann cells. Neurodiab2018, 2018.9.5, Rome, Italy.
14. ඵᏊⱥྖࠊ᪂ぢ┤Ꮚࠊຍ⸨ᩥᏊࠊ㧗ஂ㟼㤶ࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇. 㧗ࢢࣝࢥ࣮ࢫࣆࣝࣅࣥ
㓟Ḟஈୗ࡛ࡣゎ⢾⣔ࣇࣛࢵࢡࢫࡢ␗ᖖ࡟ࡼࡾ IMS32 ⣽⬊ࡢ⣽⬊Ṛࡀㄏᑟࡉࢀࡿ. ᖹᡂ 30ᖺᗘ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍. 2018.9.1, ᮾி㒔༓௦⏣༊.
15. ඵᏊⱥྖࠊ᪂ぢ┤Ꮚࠊຍ⸨ᩥᏊࠊຍ⸨ᏹ୍ࠊ୕஬୍᠇. 㧗ࢢࣝࢥ࣮ࢫእᅉᛶࣆࣝࣅࣥ㓟Ḟஈ⎔ቃୗ࡛ㄏᑟࡉࢀࡿ⣽⬊Ṛ࡟ཬࡰࡍ⢾௦ㅰኚ໬ࡢゎᯒ. ➨ 28 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍.
2018.8.5, ⚄ዉᕝ┴ᶓ὾ᕷ.
16. ኱ሙᰟᶞࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ.࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ RubiconࡢⓎ⌧ᢚไࡣ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ⚄⤒⑕≧ࢆᨵၿࡉࡏࡿ㸬➨ 28ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍. 2018.8.4. ⚄ዉᕝ┴ᶓ὾ᕷ.

－ 112 －

17. Oba M, Nagai Y, Fukui K, Sango K, Suzuki M. Therapeutic effects of Rubicon knockdown in a
Drosophila model of polyglutamine disease. ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2018.7.26㸪රᗜ┴⚄ᡞᕷ.
18. ୕஬୍᠇. ࢩࣗ࣡ࣥ⣽⬊ᰴ IFRS1 ࢆ⏝࠸ࡓ࣑࢚ࣜࣥ◊✲ࡢ⌧≧࡜ᒎᮃ. ➨ 4 ᅇ᪥ᮏ࣑࢚ࣜ
ࣥ◊✲఍኱఍. 2018.7.14, ⚄ዉᕝ┴ᶓ὾ᕷ.
19. 㕥ᮌ࣐ࣜࠊ኱ሙᰟᶞࠊ୕஬୍᠇. ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ⚄⤒ኚᛶ⑌ᝈ◊✲. ➨ 4 ᅇ᪥ᮏ࣑࢚ࣜࣥ◊✲఍኱఍. 2018.7.14, ⚄ዉᕝ┴ᶓ὾ᕷ.
20. ୕஬୍᠇. Myelin-Basic and Clinical Advances ࡢ㐍ᤖ≧ἣ࡜௒ᚋࡢᒎᮃ. ➨ 4 ᅇ᪥ᮏ࣑࢚ࣜ
ࣥ◊✲఍኱఍. 2018.7.14, ⚄ዉᕝ┴ᶓ὾ᕷ.
21. ᪂ぢ┤ᏊࠊඵᏊⱥྖࠊỈୖᾈဢࠊඵᮌᶫ᧯භࠊ୕஬୍᠇. ࢔ࣝࢻ࣮ࢫ㑏ඖ㓝⣲㑇ఏᏊࢆḞᦆࡋࡓࢩࣗ࣡ࣥ⣽⬊ᰴ IKARS1 ࡢᶵ⬟ゎᯒ. ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍.
2018.5.25, ᮾி㒔༓௦⏣༊.
22. ㉥ᕊ཭௦ࠊ㧗ஂ㟼㤶ࠊ᪂ぢ┤ᏊࠊඵᏊⱥྖࠊỌ஭ὒ௓ࠊ➉⏣⿱௓ࠊⓗሙᆂ୍㑻ࠊ▼⃝ᑗࠊ㔠⃝ᗣࠊᕝᾉ኱἞ࠊᶓ⏣ኴᣢࠊ୕஬୍᠇ࠊᏱ㒔ᐑ୍඾. ࢢࣜࢥ࣮ࣝ࢔ࣝࢹࣄࢻ࡟ࡼࡿࢽࣗ
࣮࣭ࣟࣥࢩࣗ࣡ࣥ⣽⬊Ṛㄏᑟࡢᶵᵓゎ᫂. ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍. 2018.5.25,
ᮾி㒔༓௦⏣༊.
23. ඵᏊⱥྖࠊຍ⸨ᩥᏊࠊ᪂ぢ┤Ꮚࠊ㧗ஂ㟼㤶ࠊⓗሙᆂ୍㑻ࠊᕝᾉ኱἞ࠊᏱ㒔ᐑ୍඾ࠊຍ⸨ᏹ
୍ࠊ୕஬୍᠇. 㧗ࢢࣝࢥ࣮ࢫ⎔ቃୗ࡛㸪እᅉᛶࣆࣝࣅࣥ㓟ࡣ⢾௦ㅰࢆ௓ࡋࡓ࢚ࢿࣝࢠ࣮⏘⏕⥔ᣢ࡟ᐤ୚ࡍࡿ. ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍. 2018.5.25, ᮾி㒔༓௦⏣༊.
24. 㕥ᮌ࣐ࣜࠊ኱ሙᰟᶞࠊ⚟஭ᾈ஧ࠊỌ஭⩏㝯ࠊ୕஬୍᠇㸬Knockdown of Rubicon extends lifespanand attenuates polyglutamine toxicity in Drosophila. ➨ 59 ᅇ⚄⤒Ꮫ఍Ꮫ⾡኱఍. 2018.5.23㸪໭ᾏ㐨ᮐᖠᕷ.

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 3 ௳㸧
1.

኱ሙᰟᶞࠊỌ஭⩏㝯ࠊ⚟஭ᾈ஧ࠊ୕஬୍᠇ࠊ㕥ᮌ࣐ࣜ. ࣮࢜ࢺࣇ࢓ࢪ࣮ᢚไ⺮ⓑ㉁ RubiconࡢⓎ⌧ᢚไ࡟ࡼࡿ࣏ࣜࢢࣝࢱ࣑ࣥ⑓ࣔࢹࣝࡢ⑕≧ᨵၿ. ➨ 4 ᅇ TaMa translational MeDical
science (TMED) forum. 2018.3.13, ᮾி㒔ᗓ୰ᕷ.

2.

㕥ᮌ࣐ࣜ. ࣃ࣮࢟ࣥࢯࣥ⑓ࣜࢫࢡ㑇ఏᏊ GBA ࡟ࡼࡿ Į ࢩࢾࢡࣞ࢖ࣥẘᛶቑᝏࡢ࣓࢝ࢽࢬ
࣒. ➨ 28 ᅇከᦶ࢟ࣕࣥࣃࢫ⚄⤒࢝ࣥࣇ࢓ࣞࣥࢫ. 2018.9.14, ᮾி㒔ᗓ୰ᕷ.

3.

୕஬୍᠇. ࢽ࣮ࣗࣟࣥࡸࢩࣗ࣡ࣥ⣽⬊ࡢᇵ㣴⣔ࢆ⏝࠸ࡓᮎᲈ⚄⤒㞀ᐖࡢ⑓ែゎ᫂࡜἞⒪ᡓ␎. ឡ▱Ꮫ㝔኱Ꮫ⸆Ꮫ㒊⸆≀἞⒪Ꮫㅮᗙࢭ࣑ࢼ࣮. 2018.4.13, ឡ▱┴ྡྂᒇᕷ.

IV. ≉グ஦㡯1.

୕஬୍᠇ ᶓ὾ᕷ❧኱Ꮫᐈဨᩍᤵ 㸦2017㹼㸧

2.

୕஬୍᠇ ᪥ᮏ⑓ែ⏕⌮Ꮫ఍⌮஦ 㸦2017㹼㸧

3.

୕஬୍᠇ ᪥ᮏᮎᲈ⚄⤒Ꮫ఍⌮஦ 㸦2014㹼㸧

4.

୕஬୍᠇ ࠕ⢾ᒀ⑓ᛶ⚄⤒㞀ᐖࢆ⪃࠼ࡿ఍ࠖᖿ஦ 㸦2015㹼㸧

5.

୕஬୍᠇ ᪥ᮏ⢾ᒀ⑓ྜే⑕Ꮫ఍ホ㆟ဨ㸦2007㹼㸧

6.

୕஬୍᠇ ᪥ᮏ⏕⌮Ꮫ఍ホ㆟ဨ 㸦1999㹼㸧

7.

୕஬୍᠇ ⏕⌮Ꮫ࢚ࢹࣗࢣ࣮ࢱ࣮ 㸦2015㹼㸧

8.

୕஬୍᠇ Ꮫ⩦ಟ஢ኈ ࠕ⑓ែ⏕⌮Ꮫࠖ㸦2019㹼㸧

－ 113 －

9.

㕥ᮌ࣐ࣜ ᪥ᮏ⑓ែ⏕⌮Ꮫ఍ホ㆟ဨ 㸦2018㹼㸧

10. 㕥ᮌ࣐ࣜ ᪥ᮏㄆ▱⑕Ꮫ఍ⱝᡭ◊✲⪅ጤဨ㸦2018㹼㸧
࠙ࡑࡢ௚ࠚ
11. ୕஬୍᠇ ➨ 32 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ 㸦2022 ᖺ㸧 ࡢ኱఍㛗࡟᥎ᣲ12. ୕஬୍᠇ ⛉Ꮫ㞧ㄅ Newton࣭㌟㏆࡞㸽ࡢ⛉Ꮫࠕ⾑⢾್ࠖྲྀᮦ༠ຊ⪅㸦2018 ᖺ 11 ᭶ห⾜㸧13. ୕஬୍᠇ ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍࢖ࣈࢽࣥࢢࢭ࣑ࢼ࣮ ࠕ⢾ᒀ⑓⚄⤒㞀ᐖ࡜ᶵ⬟デ᩿࡟ࡘ࠸࡚ࠥ࣌࢖ࣥࣅࢪࣙࣥࡢ⮫ᗋᛂ⏝ࠥࠖᗙ㛗. 2018.5.25, ᮾி㒔༓௦⏣༊.
14. ୕஬୍᠇ࠊ୰ᮧ஧㑻. ➨ 61 ᅇ᪥ᮏ⢾ᒀ⑓Ꮫ఍ᖺḟᏛ⾡㞟఍ࢩ࣏ࣥࢪ࣒࢘ ࠕ⚄⤒㞀ᐖࡢ
⑓ែ࡜἞⒪ʊ③ࡳࢆ⛉Ꮫࡍࡿࠖᗙ㛗. 2018.5.25, ᮾி㒔༓௦⏣༊.
15. ኱ሙᰟᶞ ➨ 28 ᅇ᪥ᮏ⑓ែ⏕⌮Ꮫ఍኱఍ Ꮫ఍ዡບ㈹㸦2018.8.4㸧
16. ኱ሙᰟᶞ ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ ࢪࣗࢽ࢔◊✲⪅࣏ࢫࢱ࣮㈹㸦2018.7.26㸧

－ 114 －

ࣉࣟࢪ࢙ࢡࢺྡ

⺮ⓑ㉁௦ㅰ◊✲ᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka, K., and Saeki, Y.
Ub-ProT reveals global length and composition of protein ubiquitylation in cells. Nature Commun.
9, 524 (2018)㻌 doi: 10.1038/s41467-018-02869-x

2.

Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K. K63 ubiquitylation triggers proteasomal
degradation by seeding branched ubiquitin chains. Proc. Natl. Acad. Sci. USA. 115, E1401-E1408(2018) doi: 10.1073/pnas.1716673115

3.

Xie, X., Matsumoto, S., Endo, A., Fukushima, T., Kawahara, H., Saeki, Y., and Komada, M.
Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules throughdeubiquitylating activities. J. Cell. Sci. 131, jcs210856 (2018) doi: 10.1242/jcs.210856

4.

Wu, W., Rokutanda, N., Takeuchi, J., Lai, Y., Maruyama, R., Togashi, Y., Nishikawa, H., Arai, N.,
Miyoshi, Y., Suzuki, N., Saeki, Y., Tanaka, K., and Ohta, T. HERC2 facilitates BLM and WRN
helicase complex interaction with RPA to suppress G-quadruplex DNA. Cancer Res. 78, 6371-6385(2018)㻌 doi: 10.1158/0008-5472

5.

Tomita, T., Hirayama, S., Sakurai, Y., Ohte, Y., Yoshihara, H., Saeki, Y., Hamazaki, J., and Murata,
S. Specific modification of aged proteasomes revealed by tag-exchangeable knock-in mice. Mol.
Cell Biol. 39, e00426-18 (2018) doi: 10.1128/MCB.00426-18

6.

Ikeuchi, K., Tesina, P., Matsuo, Y., Sugiyama, T., Cheng, J., Saeki, Y., Tanaka, K., Becker, T.,
Beckmann, R., and Inada, T. Collided ribosomes form a unique structural interface to induce Hel2driven quality control pathways. EMBO J. 38, e100276㻌 (2019)㻌 doi: 10.15252/embj.2018100276

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 7 ௳㸧1.

⏣୰ၨ஧㸦⦅⧩㸧㸸 ࠕࣉࣟࢸ࢔ࢯ࣮࣒࡜⑌⑓◊✲ࡢືྥࠖMedical Science Digest 2019 ᖺ 3
᭶ྕ 2019㸸 ⥲ㄽࠕࣉࣟࢸ࢔ࢯ࣮࣒࡜⑌ᝈ◊✲ࡢືྥࠖࢽ࣮ࣗࢧ࢖࢚ࣥࢫ♫2.

Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y. Methods to measure ubiquitin chain length andlinkage. Methods Enzymol. 618, 105-133 (2019) doi: 10.1016/bs.mie.2018.12.019.

3.

Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K. TR-TUBE system: Method for detecting
ubiquitination activity and identifying ubiquitinated substrates. Methods Enzymol. 618, 135-147(2019) doi: 10.1016/bs.mie.2018.12.032

4.

బ఑Ὀ㸸ᮍ᮶ࢆࡘ࡞ࡄ㢼ࠕࣘࣅ࢟ࢳࣥࢥ࣮ࢻࢆ㆑ࡿ࣭᧯ࡿ࣭๰ࡿࠖᐇ㦂་Ꮫ 36 ᕳ 16 ྕ
2786ࠊ2018 ᖺ ⨺ᅵ♫5.

⏣୰ၨ஧㸦⦅⧩㸧㸸ࠕ⺮ⓑ㉁௦ㅰ་Ꮫࠥᵓ㐀࣭ᶵ⬟ࡢ◊✲࠿ࡽ⮫ᗋᛂ⏝ࡲ࡛ࠖ་ᏛࡢṌࡳ㸦➨
5 ᅵ᭙≉㞟㸧2018㸸ᗎᩥ㸦⏣୰ၨ஧㸧་ṑ⸆ฟ∧

6.

బ఑Ὀ㸸⺮ⓑ㉁௦ㅰ་Ꮫࠕ⏕యศᏊࡢᾮ-ᾮ┦ศ㞳ࠖ་ᏛࡢṌࡳ 267 ᕳ 13 ྕ 1082-1088ࠊ

－ 115 －

2018 ᖺ ་ṑ⸆ฟ∧♫
7.

኱➉ྐ᫂㸸
ࠕᯞศ࠿ࢀࡋࡓ㸦ศᒱᆺ㸧ࣘࣅ࢟ࢳࣥ㙐ࡀ⺮ⓑ㉁ศゎࢆไᚚࡍࡿࡇ࡜ࢆⓎぢࠖ㒔་Ꮫ◊ NEWS, No. 31, p.5, 2018
II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 10 ௳㸧1.

Ohtake F, Saeki Y, Tanaka K. The ubiquitin ligases ITCH and UBR5 regulate proteasomal
degradation through K48/K63 branched ubiquitin chains ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍࣮࣡ࢡࢩ
ࣙࢵࣉࠕࣘࣅ࢟ࢳࣥ◊✲ࡢ᪂₻ὶ㸸ࣘࣅ࢟ࢳࣥࢥ࣮ࢻࢆ㆑ࡿ࣭᧯ࡿࠖ 2018.11.30 ⚄ዉᕝ
┴ᶓ὾ᕷ

2.

Ohtake F, Saeki Y, Tanaka K. Post-translational modification code of ubiquitin in signal transduction
and protein degradation  ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ࠕࣘࣅ࢟ࢳࣥᵝࢱࣥࣃࢡ㉁ಟ㣭⣔ࡢከᵝ࡞ᶵ⬟㸸ศゎࡔࡅࡌࡷ࡞࠸ࠊ┿᰾⏕≀ࡔࡅࡌࡷ࡞࠸ࠖ2018.9.25 ி㒔ᗓ3.

బ఑Ὀ㸸ࢣࣔࢸࢡࣀࣟࢪ࣮࡜㉁㔞ศᯒィࢆά⏝ࡋࡓࣘࣅ࢟ࢳࣥࢥ࣮ࢻࡢゎㄞ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖKick-off ࢩ࣏ࣥࢪ࣒࢘
2018㸬2018.9.18 ᮾி኱Ꮫఀ⸨ㅰᜠ࣮࣍ࣝ ᮾி㒔

4.

Keiji Tanaka: The Proteasome : Assembly and Spatiotemporal Dynamics. International Symposium
on “Proteins; from the Cradle to the Grave”, 2018.8.26㹼8.29 Enryakuji Kaikan, Shiga, Japan

5.

⏣୰ၨ஧ ⱝᖺᛶࣃ࣮࢟ࣥࢯࣥ⑓ࡢࣃ࣮࢟ࣥ㑇ఏᏊⓎぢ 20 ᖺࢆ㏄࠼࡚㸸ࡑࡢⓎᒎ࡜௒ᚋࡢ
ᒎᮃ࡟ࡘ࠸࡚ ➨ 41 ᅇ᪥ᮏ⚄⤒⛉Ꮫ኱఍ 2018.7.26㹼7.29 ⚄ᡞᅜ㝿఍㆟ሙ රᗜ┴⚄ᡞᕷ

6.

Yasushi Saeki: The Cdc48-Rad23/Dsk2 Axis Contributes to K48 Ubiquitin Chain Specificity of theProteasome. FASEB SRC “Ubiquitin and Cellular Regulation”, 2018.6.17 㹼 6.22 Snowmass,
Colorado, USA

7.

Keiji Tanaka:

The Proteasome : Assembly and spatio-temporal dynamics 

IUBMB 20182018.6.4㹼6.8 Seoul,Korea
8.

Yasushi Saeki: Ub-ProT reveals global length and composition of protein ubiquitylation in cells.
The 8th Proteasome and Autophagy Congress.

9.

2018.4.25㹼4.27 Clermont-Ferrand, France

Keiji Tanaka: Spatio-temporal dynamics of human proteasomes in stress responses. The 8th
Proteasome and Autophagy Congress.

2018.4.25㹼4.27

Clermont-Ferrand, France

10. Keiji Tanaka  Cell-mediated Immunity govern by Immunoproteasome and Thymoproteasome2018 Cold Spring Harbor Asia 2018.4.9㹼4.13 Suzhou,Chinaࡑࡢ௚ 㸦ィ 6 ௳㸧⮬⏤ᥖ㍕
1.

㜿㒊㈗๎ࠊཬᕝ኱㍜ࠊᑎ⬥ṇ๛ࠊᚋ⸨ᰤ἞ࠊ㧗ᶫᏹ㝯ࠊ኱➉ྐ᫂ࠊᕝཎ⿱அࠊᇼᒃᣅ㑻ࠊ⏿⏣ฟ✑ࠊబ఑Ὀࠊ⏣୰ၨ஧ࠊ⃝ᓮ㐩ஓࠊᚨỌᩥ⛱ ⮬↛ච␿ไᚚ࡟㛵ࢃࡿ᪂つ RING ᆺ
E3㸦RNF126㸧ࡢྠᐃ࡜ᶵ⬟ゎᯒ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ 2018.11.30 ⚄ዉᕝ┴ᶓ὾ᕷ㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

2.

ᅵᒇගࠊ᪂஭┤Ꮚࠊᾏಖឡࠊ⏣୰ၨ஧ࠊబ఑Ὀ ࣘࣅ࢟ࢳࣥ㙐㛗Ỵᐃἲࡢ㛤Ⓨ ➨ 91 ᅇ᪥ᮏ⏕໬Ꮫ఍኱఍ 2018.9.24㹼9.26, රᗜ┴⚄ᡞᕷ㸦࣏ࢫࢱ࣮Ⓨ⾲ࠊ୍⯡ཱྀ㢌Ⓨ⾲㸧

－ 116 －

3.

Ohtake F, Saeki Y, Tanaka K. The NEDD4 family ubiquitin ligase ITCH regulates proteasomal
degradation by seeding branched ubiquitin chains. FASEB ConferenceࠕUbiquitin and cellular
regulationࠖ2018.6.19 Snowmass, Colorado, USA㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

4.

Xuan Xie Deubuquitinases USP5 and USP13 are recruited to and regulate heat-induced stressgranules by deubiquitinating activities  2018 Cold Spring Harbor Asia  2018.4.9 㹼 4.13
Suzhou,China

5.

Hikaru Tsuchiya Ub-Pro T reveals global length and composition of protein ubiquitylation in cells
2018 Cold Spring Harbor Asia 2018.4.9㹼4.13

6.

Suzhou,China

Yasushi Saeki: Ubiquitin-dependent phase separation for proteasomal degradation. International
Symposium on “Proteins; from the Cradle to the Grave”, 2018.8.26㹼8.29 Enryakuji Kaikan,
Shiga, Japan 㸦࣏ࢫࢱ࣮Ⓨ⾲㸧

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 2 ௳㸧
1.

኱➉ྐ᫂ ࣘࣅ࢟ࢳࣥࢥ࣮ࢻࢆゎㄞࡍࡿ ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤࣛࣥࢳࣙࣥࢭ࣑ࢼ࣮
2018.8.8 ᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ

2.

బ఑Ὀ ࠕ⣽⬊ෆࡢࢱࣥࣃࢡ㉁ศゎࡢ࠾ࡣ࡞ࡋࠖ ᪥ᮏ኱Ꮫᩥ⌮Ꮫ㒊ᡤෆぢᏛ 2018.7.25
ᮾி㒔་Ꮫ⥲ྜᡤ

IV. ≉グ஦㡯࠙ᙺ⫋㸦ᮏົ㛵ಀ㸧ࠚ1.

⏣୰ၨ஧ බ┈㈈ᅋἲேᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ᡤ㛗ࠕ⥅⥆ࠖ

2.

⏣୰ၨ஧ බ┈㈈ᅋἲேᮾி㒔་Ꮫ⥲ྜ◊✲ᡤ ⌮஦㛗ࠕ⥅⥆ࠖ

3.

⏣୰ၨ஧ 㥖㎸⑓㝔ࠕ㐠Ⴀ༠㆟఍ࠖጤဨࠕ⥅⥆ࠖ

4.

⏣୰ၨ஧ 㐃ᦠㅮᗙᩍᤵ㸦ᐈဨᩍᤵ㸧㸸4 ኱Ꮫࠕ⥅⥆ࠖᮾி኱Ꮫ኱Ꮫ㝔᪂㡿ᇦ๰ᡂ⛉Ꮫ◊✲⛉ 2004.4.1ࠥ⌧ᅾ㸭࠾ⲔࡢỈዪᏊ኱Ꮫ኱Ꮫ㝔ே㛫ᩥ໬◊✲⛉ 1998.4.9ࠥ⌧ᅾ㸭㡰ኳᇽ኱Ꮫ་Ꮫ㒊 2016.4.1ࠥ⌧ᅾ5.

⏣୰ၨ஧ ᣍ⪸ᩍᤵ ி㒔⏘ᴗ኱Ꮫࢱࣥࣃࢡ㉁ືែ◊✲ᡤ 2016.4.1ࠥ⌧ᅾ

6.

⏣୰ၨ஧ 2016 ᖺ㹼⌧ᅾ ᪥ᮏ⏕࿨⛉Ꮫ࢔࢝ࢹ࣑࣮࣭ṇ఍ဨ࠙ᙺ⫋㸦ᮏົ௨እ㸧ࠚ
1.

⏣୰ၨ஧ ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲⿵ຓ㔠㸸≉ู᥎㐍◊✲㸦௦⾲㸧2014㹼2018 ᖺࠕ⥅⥆ࠖ

2.

⏣୰ၨ஧ ᪥ᮏᏛ⾡఍㆟఍ဨ 2017 ᖺ㹼2023 ᖺ ᪥ᮏᏛ⾡఍㆟㐃ᦠ఍ဨ3.

⏣୰ၨ஧ ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ ᡓ␎ⓗ๰㐀◊✲ᤵᴗ㸦CREST㸧◊✲㡿ᇦྡࠕᵓ㐀⏕࿨⛉Ꮫࠖ◊✲⥲ᣓࠕ⥅⥆ࠖ

4.

⏣୰ၨ஧ AMED ๰⸆➼ࣛ࢖ࣇࢧ࢖࢚ࣥࢫ◊✲ᨭ᥼ᢏ⾡ᇶ┙஦ᴗ 㢳ၥ࣭⛉Ꮫᢏ⾡ㄪᰝဨ

5.

⏣୰ၨ஧ AMED ⪁໬◊✲ PJࠕ◊✲᥎㐍఍㆟ࠖጤဨ㛗㸦2018㹼2021 ᖺᗘ㸧

6.

బ఑Ὀ ᪥ᮏ⏕໬Ꮫ఍ࠕ⏕໬Ꮫࠖㄅ௻⏬ጤဨ 2015 ᖺ㹼⌧ᅾ

7.

బ఑Ὀ ᪥ᮏᏛ⾡᣺⯆఍⛉Ꮫ◊✲㈝ጤဨ఍ᑓ㛛ጤဨ 2016.10㹼

8.

బ఑Ὀ ᅜ❧◊✲㛤Ⓨἲே᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ CREST㸦ศᢸ㸧2017ࠥ2022 ᖺࠕ⥅⥆ࠖ

9.

బ఑Ὀ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖ㡿ᇦ௦⾲ 2018.7㹼

－ 117 －

࠙ࡑࡢ௚ࠚ
1.

బ఑Ὀ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖKickoff ࢩ࣏ࣥࢪ࣒࢘୺ദ 2018.9.18

2.

బ఑Ὀ ➨ 41 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍࣮࣡ࢡࢩࣙࢵࣉࠕࣘࣅ࢟ࢳࣥ◊✲ࡢ᪂₻ὶ㸸ࣘࣅ࢟ࢳࣥࢥ࣮ࢻࢆ㆑ࡿ࣭᧯ࡿࠖ௻⏬࣭ᗙ㛗 2018.11.30

3.

బ఑Ὀ ᪂Ꮫ⾡㡿ᇦ◊✲ࠕࢣࣔࢸࢡࣀࣟࢪ࣮ࡀᣅࡃࣘࣅ࢟ࢳࣥࢽ࣮ࣗࣇࣟࣥࢸ࢕࢔ࠖ➨ 1ᅇ⌜఍㆟࣭➨ 2 ᅇࣘࣅ࢟ࢳࣥ◊✲఍ྜྠ఍㆟୺ദ 2019.1.14㹼16－ 118 －

ࣉࣟࢪ࢙ࢡࢺྡ

⣽⬊⭷◊✲ᐊ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Yuasa N, Kawashima I.:Methods for preparation of anti-ganglioside monoclonal antibodies.;
Gangliosides: Methods and Protocols, Methods in Molecular Biology 1804, 285-291, 2018.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 5 ௳㸧⮬⏤ᥖ㍕
1.

ᑠ಴₩ࠊ➟ཎᾈ஧㸸HGS/C ࢱࣥࣃࢡ㉁⏤᮶⭘⒆ቑṪᢚไ࢜ࣜࢦ࣌ࣉࢳࢻࡢ᳨⣴ ➨ 77 ᅇ
᪥ᮏ⒴Ꮫ఍Ꮫ⾡⥲఍ 2018.9.27㹼9.29 ኱㜰

2.

Kohji Kasahara, Yasushi Shimoda, and Keisuke Komatsuya 㸸Function of ganglioside-specific rafts
in cerebellar granule cells㸬2nd Japan-Korea Lipid Joint Symposium㸬2018.9.12㹼9.14. Sapporo3.

➟ཎᾈ஧㸸ࢣࣔ࢝࢖ࣥ SDF-1Į ࡟ࡼࡿ⬡㉁ࣛࣇࢺࢆ௓ࡍࡿ⾑ᑠᯈจ㞟ᶵᵓ ᮾ໭࣐࣊ࢺࣟ
ࢪ࣮ࢿࢵࢺ࣮࣡ࢡࢭ࣑ࢼ࣮ 2018.9.2 ᐑᇛ┴௝ྎᕷ

4.

⚟ᒣ⨾ᬛᏊࠊ஭ཱྀᬛᘯࠊᑠᯇ㇂ၨ௓ࠊᕝᓥ⫱ኵࠊ㣤⏣࿴Ꮚࠊୗ௰ᇶஅࠊ✀Ꮚᓥᖾ♸ࠊཎᏕᙪࠊᒣᮏṇ㞞ࠊ➟ཎᾈ஧㸸ࢣࣔ࢝࢖ࣥ SDF-1Į ࡟ࡼࡿ Jurkat T ⣽⬊ࡢ⬡㉁ࣛࣇࢺ࡜⢾㙐ࢆ௓ࡍࡿࢩࢢࢼࣝఏ㐩 ➨ 37 ᅇ᪥ᮏ⢾㉁Ꮫ఍ᖺ఍ 2018.8.30 ᐑᇛ┴௝ྎᕷ

5.

ᑠᯇ㇂ၨ௓ࠊ஭ཱྀᬛᘯࠊᕝᓥ⫱ኵࠊ㟖⏣㟹ࠊ➟ཎᾈ஧㸸GPI ࢔࣮ࣥ࢝ᆺ⚄⤒⣽⬊᥋╔ศᏊ
NB-3 ࡢᑠ⬻㢛⢏⣽⬊ GD1b ࣛࣇࢺ࡟࠾ࡅࡿ Yes ࢆ௓ࡋࡓࢩࢢࢼࣝఏ㐩 ➨ 37 ᅇ᪥ᮏ⢾㉁Ꮫ఍ᖺ఍ 2018.8.30 ᐑᇛ┴௝ྎᕷ

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯1.

➟ཎᾈ஧㸸᪥ᮏᏛ⾡᣺⯆఍≉ู◊✲ဨ➼ᑂᰝ఍ᑓ㛛ጤဨ 2017.8.1㹼2018.7.31－ 119 －

2.

➟ཎᾈ஧㸸᪥ᮏᏛ⾡᣺⯆఍ᅜ㝿஦ᴗጤဨ఍᭩㠃ᑂᰝဨ 2017.8.1㹼2018.7.31

3.

ᑠ಴₩㸸ᰴᘧ఍♫⢾㙐ᕤᏛ◊✲ᡤ ඹྠ◊✲ࠕHGS ࢆᶆⓗ࡜ࡋࡓ᪂つ⭘⒆ቑṪᢚไ࢜ࣜࢦ
࣌ࣉࢳࢻࡢ㛤Ⓨࠖ 2018.4.1㹼2019.3.31

4.

ᑠ಴₩㸸኱㜰ၟᕤ఍㆟ᡤ Drug Seeds Alliance Network Japan (DSANJ) Bio Conference ཧຍ
2018.8.30－ 120 －

ࣉࣟࢪ࢙ࢡࢺྡ

ࣃ࣮࢟ࣥࢯࣥ⑓◊✲ᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 1 ௳㸧
1.

Hagihara H, Fujita M, Umemori J, Hashimoto M, Miyakawa T. Immature-like molecular expression
patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant ȕsynuclein. Mol Brain. 㸦ᰝㄞ᭷㸧2018 Jul 6;11(1):38. doi: 10.1186/s13041-018-0378-3.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 4 ௳㸧
1.

Takamatsu Y, Fujita, M, Ho G, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E andHashimoto M. Motor- and non-motor symptoms of Parkinson̓s disease; antagonistic pleiotropy
phenomena derived from Ș-synuclein evolvability? Parkinsons Dis.㸦ᰝㄞ᭷㸧 2018 in press

2.

Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Waragai M.
Possible role of the polyglutamine elongation in evolution of amyloid-related evolvability. J
Huntingtons Dis.㸦ᰝㄞ᭷㸧 2018 Oct 26. doi: 10.3233/JHD-180309. [Epub ahead of print]

3.

Hashimoto M, Ho G, Takamatsu Y, Shimizu Y, Sugama S, Takenouchi T, Waragai M, Masliah E.
Evolvability and neurodegenerative disease: antagonistic pleiotropy phenomena derived fromamyloid aggregates. J Parkinsons Dis. 㸦ᰝㄞ᭷㸧2018;8(3):405-408. doi: 10.3233/JPD-181365.

4.

Waragai M, Ho G, Takamatsu Y, Shimizu Y, Sugino H, Sugama S, Takenouchi T, Masliah E,
Hashimoto M. Dual therapy strategy for modification of adiponectin receptor signaling in agingassociated chronic diseases. Drug Discov Today. 㸦ᰝㄞ᭷㸧 2018 Jun;23(6):1305-1311. doi:
10.1016/j.drudis.2018.05.009.

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯－ 121 －

ࣉࣟࢪ࢙ࢡࢺྡ

ື≀ᐇ㦂㛤ⓎᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 2 ௳㸧
1.

Matsuoka K, Wada K, Miyasaka Y, Yasuda SP, Seki Y, Nishito Y, Yonekawa H, Taya C, Shitara H,*Kikkawa Y (2019) OHC-TRECK: A Novel System Using a Mouse Model for Investigation of the

Molecular Mechanisms Associated with Outer Hair Cell Death in the Inner Ear. doi:
10.1038/s41598-019-41711-2 Sci Rep 9(1):5285.
2.

Sano H, *Namekata K, Kimura A, Shitara H, Guo X, Harada C, Mitamura Y, Harada T (2019)
Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal
tension glaucoma. doi: 10.1038/s41419-019-1365-z Cell Death Dis 10(2):75.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 0 ௳㸧⮬⏤ᥖ㍕

III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯－ 122 －

ࣉࣟࢪ࢙ࢡࢺྡ

◊✲ᢏ⾡㛤ⓎᐊI. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 6 ௳㸧
1.

Matsuoka K, Wada K, Miyasaka Y, Yasuda SP, Seki Y, Nishito Y, Yonekawa H, Taya C, Shitara H,
Kikkawa Y. (2019) OHC-TRECK: A Novel System Using a Mouse Model for Investigation of the
Molecular Mechanisms Associated with Outer Hair Cell Death in the Inner Ear. doi:
10.1038/s41598-019-41711-2. Sci Rep. 9(1):5285.

2.

Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu
Y, Uchino S, Ikeda K (2019) Effects of rapamycin on social interaction deficits and gene expression
in mice exposed to valproic acid in utero. Mol Brain 12:3.

3.

Tanaka K, Ikeda N, Miyashita K, Nuriya H, Hara T㸦2018㸧DEAD box protein DDX1 promotes
colorectal tumorigenesis through transcriptional activation of the LGR5 gene. Cancer Sci 109:2479-2489

4.

Tanaka M, Sato A, Kasai S, Hagino Y, Kotajima-Murakami H, Kashii H, Takamatsu Y, Nishito Y,
Inagaki M, Mizuguchi M, Hall FS, Uhl GR, Murphy D, Sora I, Ikeda K (2018) Brain
hyperserotonemia causes autism-relevant social deficits in mice. Mol Autism 9:60.

5.

Ide S, Ikekubo Y, Hua J, Takamatsu Y, Uhl GR, Sora I, Ikeda K (2018) Reward-enhancing effect of
methylphenidate is abolished in dopamine transporter knockout mice: a model of attention
deficit/hyperactivity disorder. Neuropsychopharmacol Rep 38:149-153.

6.

Fujita M, Hagino Y, Takamatsu Y, Shimizu Y, Takamatsu Y, Ikeda K, Hashimoto M (2018) Early
manifestation of depressive-like behavior in transgenic mice that express dementia with Lewy
bodies-linked mutant beta-synuclein. Neuropsychopharmacol Rep 38:95-97.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 1 ௳㸧
1.

Takamatsu Y (2019) Center for basic technology research in Tokyo Metroporitan Institute ofMedical Science. 2019.3.2 AsCNP-ASEAN2019, Yogyakarta, Indonesiaࡑࡢ௚ 㸦ィ 7 ௳㸧⮬⏤ᥖ㍕
1.

Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino
S, Ikeda K (2018) Rapamycin improves social deficits in the mice treated prenatally with valproi－ 123 －DFLG WK $QQXDO 0HHWLQJ $PHULFDQ &ROOHJH RI 1HXURSV\FKRSKDUPDFRORJ\ $&13    )ORULGD86$ඵᮌᣅဢࠊ㖊࿅ెྐࠊྜྷ⏣༓⣫ࠊす⸨ὈᫀࠊṊᬛ࠶࡙ࡉࠊᐑୗ࿴ஓࠊ∾ᫀḟ㑻ࠊཎᏕᙪ
  ᛴᛶ 7 ࣜࣥࣃⱆ⌫ᛶⓑ⾑⑓⣽⬊ࡢቑṪࢆ≉␗ⓗ࡟ᢚ࠼ࡿ໬ྜ≀ࡢᶆⓗศᏊ᥈⣴➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ 㹼 ⚄ዉᕝ┴ᶓ὾ᕷṊᬛ࠶࡙ࡉࠊ኱἟ᗣᖹࠊ✀Ꮚᓥᖾ♸ࠊ┦ᇉᩄ㑻ࠊす⸨ὈᫀࠊཎᏕᙪ   ᑑ࿨Ṛ┤๓ࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡛Ⓨ⌧ኚືࡍࡿ㑇ఏᏊ⩌ࡢྠᐃ ➨  ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍
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－ 124 －

ࣉࣟࢪ࢙ࢡࢺྡ

⚄⤒⑓⌮ゎᯒᐊ

I. ㄽᩥ➼Ⓨ⾲ཎⴭㄽᩥ 㸦ィ 4 ௳㸧
1.

Tanikawa S, Kato Y, Tanino M, Terasaka S, Kurokawa Y, Arai N, Nagashima K, Tanaka S. Autopsy
report of a late delayed radiation injury after a period of 45 years. Neuropathology
https://doi.org/10.1111/neup.12528

2.

Koga M, Masukawa D, Komori T, Seki E, Nakamura F, Watanabe S, Arai N. Immunoreactivity ofa G protein-coupled L-DOPA receptor GPR143, in Lewy bodies Neuroscience Research 2018 Dec
24. pii: S0168-0102(18)30598-4. doi: 10.1016/j.neures.2018.12.004. [Epub ahead of print]

3.

Makino Y., Arai N., et al. Traumatic axonal injury revealed by postmortem magnetic resonanceimaging: a case report. Legal Medicine 2019 36:9-16

4.

Kawasaki T., Shin M., Kimura Y., Umitsu Y., Matsumura G., Yokochi F., Okiyama R., Taniguchi M.,
Arai N., J Clin Neurosci. 2018 Jul;53:193-202. doi: 10.1016/j.jocn.2018.04.029. Epub 2018 May 5.

ࡑࡢ௚⥲ㄝㄽᩥࠊⴭ᭩ࠊヂ᭩ࠊ㞧ㄅ⦅㞟ࠊሗ࿌᭩➼ 㸦ィ 0 ௳㸧

II. Ꮫ఍➼Ⓨ⾲ᣍᚅㅮ₇ 㸦ィ 0 ௳㸧ࡑࡢ௚ 㸦ィ 1 ௳㸧⮬⏤ᥖ㍕
1.

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ࢭࣥࢱ࣮ ᪂₲┴III. ࡑࡢ௚ࡢⓎ⾲㸦ィ 0 ௳㸧

IV. ≉グ஦㡯－ 125 －

東京都医学総合研究所年報（2019 年版）
2019 年 8 月発行
編集・発行

公益財団法人〒156-8506
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東京都医学総合研究所

東京都世田谷区上北沢 2-1-6
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