PASCAL SynthesisⓇ

PhotocoagulatorTMIndustry Leading
PAttern SCAnning Laser
Technology
PASCAL® Synthesis

Experience the PASCAL® Advantage
The collaboration between researchers and clinical experts resulted in a laser system recognized andused by physicians worldwide.

TM

The PASCAL technology was

Exclusive Precision Spots with

developed in partnership

Multi-Fiber Beam Technology

with Stanford University

Reduced power and shortpulses produce lessdiscomfort during treatment

PASCAL® represents a quantum leap in ophthalmic treatment technology and iscommitted to helping you deliver effective results for your patients. Demanding
ophthalmologists choose PASCAL® because of its speed and ease of use.
Developed in partnership with Stanford University, the PASCAL® method of

Rapid pattern scanning

Precise alignment and continuous

PASCAL HUD 1

laser pulse directed byophthalmic image projector

laser delivery

high speed galvanometers

photocoagulation treats retinal retinal conditions using a single spot ora user-selected pattern array. Most importantly, it was designed to provide,
control and flexibility in the treatment of eye conditions.
Fine view by enhanced

Endpoint Management

Pattern Scanning Laser

laser delivery slit lamp

for sub-threshold treatment1

Trabeculoplasty(PSLT) 1 for IOP reduction 2

Unlike conventional laser burns,
PASCAL’s shorter pulse duration(10 ms) results in faster procedureswith less pain, collateral damage
and scarring for your patients3 .
*1 Manish Nagpal et. al., “Comparison of laser photocoagulation for diabetic retinopathy using 532-nm standard laser
versus multisport pattern scan laser. “ RETINA 30:452-458,2010*2 Lavinsky D, et. al., "Subvisible retinal laser therapy: titration algorithm and tissue response.", Retina. 2014」an:34(1):87-97*3 別売オプション

PASCAL

Conventional Laser

Courtesy: Dr. Daniel Palanker Associate Professor Department of Ophthalmology,
School of Medicine, and Hansen Experimental Physics
Laboratory Stanford University.

1. Optional
2. Mauricio Turati, Felix Gil-Carrasco, Adolfo Morales, Hugo Quiroz-Mercado, Dan Anderson, George Marcellino, Georg Schuele, Daniel
Palanker. “Patterned Laser Trabeculoplasty.” Ophthalmic Surg Lasers Imaging 2010;41: 538-545.
3. Manish Nagpal et. al., “Comparison of laser photocoagulation for diabetic retinopathy using 532-nm standard laser versus multisport
pattern scan laser. “ RETINA 30:452-458,2010

The new HUD-1

Now Featuring
A New Laser Delivery Slit Lamp
SL-PA04

Head Up Display
simplifies thetargeting of yourtreatment areanew
Ergonomic Design and Improved Optical Design
Improved coaxiality between the slit illumination and the aiming beamprovides better visibility of the peripheral retina.

Comfortable observation with our NEW binocular system
The CB-8 binocular system with 8-degree angle provides clear vision.
The smooth movement of the PD adjustment makes it easier to find acomfortable PD range. New magnification configuration improves visibility

Head up display HUD-1

of the treatment area. The 5x, 8x, 13x, 20x and 32x magnification grouping
allows for a wider view of the treatment area.

The HUD-1 is an ophthalmic image projector
used as an accessory to PASCAL® Synthesis and
TwinStar lasers. The HUD-1 lets you compare thePower Adjustment Knobtarget area of treatment with a side-by-side view

Quick and precise adjustment of the laserof a reference image previously obtained fromthe patient’s fundus for location and assessment.

LEARN MORE

treatment power.

Multiple types of eye-fundus images can bedisplayed, including FA/IA, OCT, B scan and
OCTA images.

https://www.youtube.com/watch?v=JifgNHA3HHM&feature=youtu.be

LED Illumination
Sharp and homogeneous LED illumination for
comfortable viewing

Gooseneck Fixation Target
Easy to adjust the fixation target.

Micro-manipulator
Allows precise alignment of aiming beamand treatment delivery.
Observation of image by operator with the HUD-1* Courtesy: Masakazu Morioka, MD, Department of Ophthalmology Faculty of Medical Sciences, University of Fukui

Endpoint Management Sub-threshold
Treatment for Retinal Disorders
TM

Endpoint Management
Clinical Case

TM

Endpoint Management (EpM)* is a pattern sub-threshold retinal laser therapy that uses a uniquealgorithm to control laser power and pulse duration, optimizing the therapeutic effect of the laser
at sub-visible levels.
Diabetic Macular Edema

Endpoint Management is
THRESHOLDS

mathematically precise

HEMORRHAGE

The Arrhenius Integral coupled with extensive data on
for Endpoint Management. By use of this formula,

NON-VISIBLE

POWER

retinal laser-tissue interactions defines the algorithms

BARELY VISIBLE

Pre-EpM VA 20/60

1 year and 9 months Post-EpM VA 20/20

FA
OCT
NON-THERAPEUTIC

heat induced changes in the retina are controlled as
TIME

Endpoint Management simultaneously modulates

ENDPOINT
MANAGEMENTALGORITHMS

Physician:the laser power and duration, providing linear control
over a non-linear process.

Patient:

Dr. Daniel Lavinsky | Porto Alegre, Rio Grande do Sul, Brazil
64 years old with Type 2 DM for over 20 years. Severe nonproliferative diabetic retinopathy
with macular edema OU. Patient submitted to one intravitreal injecton of Ranibizumab. She
had a panic attack during the procedure and refused additional injections.

LandmarkTM Patterns
The Landmark feature is a useful tool for tracking the

Diabetic Retinopathy

sub-visible areas which have been treated, assistingwith the treatment process and taking the guessworkout of successive treatments.

Pre-EpM VA 20/60

Easy Operation

1 year Post-EpM VA 20/20

The yellow dots displayed on the user interface
treatment pattern display indicate the laser spots

EpM OFF

that will be delivered using the energy level set by
Endpoint Management. While Endpoint Management
is active, the red dots indicate the laser spots thatwill be delivered at the titration energy level ("100%40%

EpM ON /Landmark OFF

EpM ON /Landmark ON

Physician:Patient:

Dr. Daniel Lavinsky | Porto Alegre, Rio Grande do Sul, Brazil
46 years old, male with decreased visual acuity since childhood due to nystagmus. Patientrefused use of steroids or other medications.

level") and will provide the "Landmark" reference
points outlining the treated area.
* Courtesy: Lavinsky D, Palanker D. Non Damaging photothermal therapy for the retina: initial clinical experience with chronic
central serous retinopathy.Retina. 2015;35(2):213-22.

*EpM is optional softwarePSLT (Pattern Scanning Laser
Trabeculoplasty) treatment
for IOP Reduction

PASCAL's Versatility MaximizesYour Workflow

Pattern Scanning Laser Trabeculoplasty (PSLT)*1 is a tissue-sparing laser treatment forMore Patterns. More Treatment Options.

TM

reducing intraocular pressure in open angle glaucoma. PSLT provides a rapid, precise, andminimally traumatic computer-guided treatment that applies a sequence of patterns onto

PASCAL offers a vast selection of patterns. The
extensive pattern palette provides many variations tosuit nearly every clinical need.

the trabecular meshwork.*2

Clear advantages of PSLTIOP After PSLT・Computer guided treatment
・Sub-visible procedurein 6 months*
・Ability to retreat if necessary

PG OffBright and clear continuous aiming beam can help
the operator to precisely aim at the target position.

25

IOP (mmHg)

・Clinical studies show an IOP reduction of 24%

PSLT
30

Uninterrupted aiming beam

20
15
10
5
0

0d 1W 1M 2M 3M 4M 5M 6M 8M 9M 10M 12M 16M 18M

Follow-up Period
IOP reduction of >-30% was maintained through 18months
By Miho Nozaki, MD, PHD, and Kaweh Mansouri, MD,
MPH/Nov/Dec 2015 Insert to Glaucoma Today

Ease of operation
PSLT provides a computer guided placement of thetreatment patterns ensuring full coverage of thetrabecular meshwork and eliminating the chance

Multi-Fiber Beam Delivery System
PASCAL Synthesis multi-fiber beam delivery provides one dedicated fiber optic for each spot size.
This increases depth of field compared to zoom optic laser systems.

of overlap.
Multi-Fiber Beam Delivery

Zoom optic laser systems
ILM

ILM

RPE

RPE

Wide depthof focus

Profile image of beam delivery:
PASCAL has uniform energy distribution*1 PSLT is optional software*2 Mauricio Turati, Felix Gil-Carrasco, Adolfo Morales, Hugo Quiroz-Mercado, Dan Anderson, George Marcellino, Georg Schuele, Daniel Palanker.
“Patterned Laser Trabeculoplasty.” Ophthalmic Surg Lasers Imaging 2010;41: 538-545.

Narrow
depth of
focus

Profile image of beam delivery:
Other lasers have "hot spots" in the beam profile

Sophisticated Technology,
Elegantly Designed

Case Images

In order to help you and your patients, we never stop improving. When you understand the science

Proliferative diabetic retinopathy

Retinal Holebehind our advancements, you’ll understand why PASCAL is really a synthesis of innovations,
all working together to further the field of ophthalmology.

PASCAL Synthesis
・Available in 577 and 532 nm wavelengths(yellow/green)・Integrates seamlessly with Topcon SL-PA04,
SL-D7, Haag-Streit™, BM900 and BQ900

Topcon SL-PA04

Topcon SL-D7

G4 and Y4

G7 and Y7

LEARN MORE

PASCAL TwinStar

https://www.youtube.com/watch?v=nVHqbhl9QbY&feature=youtu.be

Post laser
photocoagulation

・Includes both 577 nm + 638 nm wavelengths(yellow+red) in a single system

Post laser
photocoagulation( 2 months )*Courtesy: Hiroyuki Nomoto, MD, Nomoto Eye clinic

・Integrates seamlessly with Topcon SL-PA04
slit lamp

Topcon SL-PA04 (TwinStar)

PASCAL LIO*
(Laser Indirect Ophthalmoscope)

Pattern scanning method is・Allows physicians to offer laser photocoagulation

the preferred way andtreatments to patients unable to sit at a slit lamp

I believe it’s standard of care.

・Small and lightweight headset battery offers up
to 2 hours of use without recharging* Optional accessory to Synthesis, not available with TwinStar

Mark S. Blumenkranz, MD
PASCAL LIO

HJ Smead Professor and Chair Director of the Byers Eye Instituteat Stanford University

Specification

Laser

Synthesis (Y7 / G7 / Y4 / G4)

Synthesis TwinStar

Available in 577nm or 532nm Optically

577nm , 638nm*1

Pumped Semiconductor (OPSL)
Patterns

Single Spot, Array, Triple Arc*2, Triple Ring, Arc, Line, Circle, Enhanced Octants (EpM*3), Wedge, Hexagon

Power

0 - 2000mW

577nm: 0 - 2000mW
638nm: 0 - 600mW

Power Control

3-D Controller and Touch Screen User Interface*4

Treatment

Pulse Durations 5 to 1000ms*5

Aim Beam

635nm diode670nm diodeAim Beam Power

Adjustable to < 1mW

Delivered Spot Size

577nm: 50, 100, 200, 400μm

50, 100, 200, 400μm

638nm: 60, 200μm
User Interface
Slit Lamp Compatibility

3D Controller and Touch Screen Control Panel Display (26.5 cm; 10.4 in)*4Topcon SL-PA04

Haag-Streit BM900 and BQ900,Topcon SL-PA04 and SL-D7

Laser Console Dimensions

Height: 23 cm (9 in)Length: 31 cm (12 in)
Width: 38 cm (15 in)
Weight: 15 kg (35 lbs)

Input Power Requirement

100 - 240 VAC; 50/60Hz 200VA

Cooling

TEC / Air Cooled*1 : 577nm is for Single, Pattern scan, PSLT and Endpoint Management. 638nm is only for single spot.
*2: Triple arc is only for Angle treatment by PSLT
*3: EpM is optional software*4: Optional accessory*5: Pulse Durations 5ms is only for Triple arc

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IMPORTANT In order to obtain the best results with this instrument, please be sure to review all user instructions prior to operation.
Not available for sale in all countries. Please check with your local distributor for availability in your country.
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