APPS 2013 Program
Day 1: Sunday July 21
11:30

Doors Open

12:30 – 12:40

Opening address by Susumu Shirabe (Nagasaki Univ.)

12:40 – 13:30

Keynote Lecture 1 Chair: Noriyuki Nishida (Nagasaki Univ.)
David A. Harris (Boston Univ.)
THE CELLULAR PRION PROTEIN:
A RECEPTOR FOR NEUROTOXIC PROTEIN OLIGOMERS

13:30 – 14:20

Keynote Lecture 2 Chair: Suehiro Sakaguchi (Univ. of Tokushima)
Joaquín Castilla (CIC bioGUNE)
Recombinant prions. A new method for studying prions

14:20 – 14:40

Coffee break

14:40 – 15:30

Oral Presentation of Selected Posters (1)(Presentation & Audience participation: 10 min per person)

Chair: Ryuichiro Atarashi (Nagasaki Univ.)
1. Yasushi Iwasaki (Aichi Medical Univ.), Poster 13
Neuropathological investigation of the olfactory bulb andolfactory tract in sporadic Creutzfeldt-Jakob disease
2. Yun-Jung Lee (Hallym Univ.), Poster 41
Defining Korean Creutzfeldt-Jakob disease strains and theirtransmissible properties
3. Hanae Takatsuki (Nagasaki Univ.), Poster 42
Quantitative analysis of seeding activity in human priondisease materials using end-point RT-QUIC
4. Motohiro Horiuchi (Hokkaido Univ.), Poster 12
Analysisofmicroglial

activation

stateinbrains

prion-infected mice
5. Suehiro Sakaguchi (Univ. of Tokushima), Poster 24
Prions impair post-Golgi trafficking of membrane proteinsof

15:30 – 17:00

Round Table 1:

Diagnosis of Prion diseases(Presentation & Audience participation: 30 min per person)

Chairs: Steven John Collins (Univ. of Melbourne)&Yong Sun Kim (Hallym Univ.)
1. Alison J. E. Green (Univ. of Edinburgh)
Cerebrospinal fluid RT-QuIC in the diagnosis of sporadic
Creutzfeldt-Jakob disease
2. Makoto Sasaki (Iwate Medical Univ.)
Current concepts in MR imaging of prion diseases
3. Nobuyuki Okamura (Tohoku Univ.)
Imaging prion and other misfolded protein deposits using
PET
17:00 – 18:30

Poster Session

18:00 – 18:30

Executive APSPR Committee Meeting

19:00 –Dinner, Hotel Europe (Rembrandt Hall)

Day 2: Monday July 22
8:00 – 8:50

Oral Presentation of Selected Posters (2)(Presentation & Audience participation: 10 min per person)

Chair: Motohiro Horiuchi (Hokkaido Univ.)
1. Shigeo Fukuda (Hokkaido Animal Research Center), Poster 5
Detection specificity of salivary BSE PrPSc by PMCA
2. Takehiro Nakagaki (Nagasaki Univ.), Poster 23
FK506 reduces abnormal prion protein through the activationof autolysosomal degradation and prolongs survival inprion-infected mice
3. Yuji Sakasegawa (Tohoku Univ.), Poster 25
Glycerol enhances the PrPres production via a PI3K signaling
pathway in prion-infected neuroblastoma cells
4. Genjiro Suzuki (RIKEN), Poster 32
The mechanism of asymmetric distribution of prion proteinsin the yeast cell
5. Hideki Taguchi (Tokyo Institute of Technology), Poster 34
Mechanism underlying difference between transmissible
prions and nontransmissible amyloids
8:50 – 10:05

Special Symposium on non-prion amyloid(Presentation & Audience participation: 25 min per person)

Chair: Motomasa Tanaka (RIKEN)
1. Yuji Goto (Osaka Univ.)
Toward a comprehensive understanding of protein folding
and misfolding
2. Keiichi Higuchi (Shinshu Univ.)
Prion-like transmission of systemic amyloidoses
3. Tsuyoshi Hamaguchi (Kanazawa Univ.)
Propagation of cerebral -amyloidosis
10:05 – 10:30

Poster Session and Coffee break

10:30 – 11:00

APSPR General Assembly11:00 – 12:15

Round Table 2:

Prospective Drug discovery in prion(Presentation & Audience participation: 25 min per person)

Chairs: Hidehiro Mizusawa (Tokyo Medical and Dental Univ.)&Chairs: Masahito Yamada (Kanazawa Univ.)
1. Katsumi Doh-ura (Tohoku Univ.)
Drug discovery for prion diseases: dream and reality
2. Kazuo Kuwata (Gifu Univ.)
Medical chaperone- a novel strategy for the logical drug
design for prion diseases
3. Tsuyoshi Hamada (Nagasaki Univ.)in silico screening on DEGIMA supercomputer
12:15 – 12:30

Awarding Ceremony by Yong-Sun Kim & Noriyuki Nishida

12:30 – 12:40

Closing Remarks by Susumu Shirabe