2017 APPS – Melbourne
Program
DAY 1 : Friday 20th October
12:00 - 13:00

Registration Opens including poster hanging

13:00 – 13:10

Opening Remarks

Steven Collins &Katsumi Doh-ura

Keynote LectureTime
13:10 – 14:00

Chairs: Motomasa Tanaka & Kazuo Kuwata
Presentation Title
Synthetic prions: successes and contentions

Session 1

Theme: Determinants of prion transmission

Chairs: Ryuichiro Atarashi & Noriyuki Nishida
Time
Presentation Title
14:00 - 14:20
Understanding the Mechanism of Prion Transmission
14:20 – 14:40
Molecular basis for diversification of yeast prion strain conformation
14:40 – 15:00
Mechanisms of intercellular prion transfer by extracellular vesicles
15:00 – 15:20
Coffee BreakKeynote Speaker
Chairs: Hidehiro Mizusawa & Victoria Lawson
Time
Presentation Title
Sc
Kinetics of Aβ/PrP -amyloid formation and accumulation in subacute
15:20 – 16:10
Creutzfeldt-Jakob and chronic Alzheimer’s disease

Session 2Time
16:10 – 16:25
16:25 – 16:40
16:40 – 16:55
16:55 – 17:10
17:10 – 17:25
17:25 – 17:40
17:40 – 18:40
18:00 – 18:30
19:00 – 23:00

Speaker
Giuseppe Legname

Speaker
Jiyan MaMotomasa Tanaka
Andrew HillSpeakerColin Masters

Theme: Prion-like phenomena and prion pathogenesis
Chairs: Nobuo Sanjo & Xiao-Ping Dong
Presentation Title
Transmission of amyloid beta
Control of PrPSc levels by arginine polymers and related peptides
Increased citrullination of myelin basic protein in prion pathogenesis
Differential effects of anti-prion treatments highlight differences in
the pathogenesis of sporadic and familial forms of prion disease andidentifies novel mode of action for pentosan polysulfate
RT-QuIC of alpha-synuclein
In vivo acute prion neurotoxicity
Poster review session – Kenneth Myer Building Foyer
APSPR Board member meeting – Level 5 Boardroom
Evening function – Melbourne Museum with access to the First
Peoples standing exhibition: Bus departing at 18:50 from front ofKenneth Myer BuildingSpeaker
Tsuyoshi Hamaguchi
Chongsuk Ryou
Eun-Kyoung Choi
Victoria Lawson
Kazunori Sano
Matteo Senesi

DAY 2 : Saturday 21st October
Session 3-1

Theme: Prion neuropathology and diagnostics

09:45 – 10:00
10:00 – 10:20

Chairs: Masahito Yamada & Andrew Hill
Presentation Title
Pathogenesis and microglial involvement
Clinicopathology of human prion diseases
Diagnostic approach for a novel acquired CJD subgroup, acquired CJDMMiK
Cerebral organoid models of prion disease
Coffee BreakSession 3-2

Theme: Prion neuropathology and diagnostics

Time
09:00 – 09:15
09:15 – 09:30
09:30 – 09:45

11:10 – 12:05
12:05 – 13:00

Chairs: Steven Collins & Katsumi Doh-ura
Presentation Title
Update on the utility of techniques for CSF biomarkers
Exosomes as a blood biomarker for CJD
MRI in the diagnosis of prion diseases
A global collaboration supporting patients, their families and those atincreased risk of developing prion disease.
Poster review session – Kenneth Myer Building Foyer
Lunch – Kenneth Myer Building Foyer

Session 4

Theme: Animal prion diseases

Time10:20 – 10:35
10:35 – 10:50
10:50 – 11:05
11:05 – 11:10

Chairs: Shirou Mohri & Kevin Keough
Presentation Title
CWD update
BSE update
Poster abstract / Hot Topics
Chairs: Naomi Hachiya & Yong-Sun Kim
TimePresentation Title
Bovinized transgenic mouse-passaged CH1641-like scrapie prion
13:40 – 13:52
shows different properties from both classical and atypical BSE prions
Ultra-efficient Amplification of Abnormal Prion Protein by Modified
13:52 – 14:04
Protein Misfolding Cyclic Amplification with Electric Current
14:04 – 14:16
Regulation of RhoA activity by the cellular prion protein.
Analysis of clinical features of patients with lower limb muscle
14:16 – 14:28
weakness in GSS with P102L mutation
14:28 – 14:40
The origin of de novo prions formed during PMCA
Time
13:00 – 13:20
13:20 – 13:40

14:40 – 14:55

Prizes/awards - farewell address - announcement of APPS 2018

14:55 – 15:10

APSPR General Assembly

Speaker
Motohiro Horiuchi
Yasushi Iwasaki
Atsushi KobayashiCathryn HaighSpeaker
Katsuya SatoLesley Cheng
Nicholas TrostSuzanne Solvyns

Speaker
Yoshifumi Iwamaru
Yuichi Matsuura
Speaker
Kohtaro Miyazawa
Jeong-Ho Park
Hee-Jun Kim
Fumiko Furukawa
Simon Drew
Steven Collins &Naomi Hachiya