SAFETY DATA SHEET

Revision Date 25-Jul-2022

Revision Number 4
NGHS / English_____________________________________________________________________________________________The supplier identified below generated this SDS using the UL SDS template. UL did not test, certify, or approve the substance described in this SDS, andall information in this SDS was provided by the supplier or was reproduced from publically available regulatory data sources. UL makes no representations
or warranties regarding the completeness or accuracy of the information in this SDS and disclaims all liability in connection with the use of this informationor the substance described in this SDS. The layout, appearance and format of this SDS is © 2014 UL LLC. All rights reserved.

_____________________________________________________________________________________________

1. IDENTIFICATION
Product identifier
Product Name

SMARTvectorLentiviral shRNA, SMARTvector InducibleLentiviral shRNA,
shMIMICLentiviral microRNA, shMIMICInducible Lentiviral microRNA, GIPZ
Lentiviral shRNA, Decode, Precision LentiORF, Edit-R Lentiviral Cas9, LentiviraldCas9-VPR, Edit-R Lentiviral sgRNA, CRISPRa Lentiviral sgRNA, Edit-R All-inone Lentiviral sgRNA, CRISPRi Lentiviral Blast-dCas9, CRISPRi Lentiviral sgRNA,FGS CRISPRko

Other means of identification
Product Code(s)VARIOUS- LENTIVIRAL PARTICLE FORMAT

Recommended use of the chemical and restrictions on use
Recommended Use

For research use only

Restrictions on use

No information available

Details of the supplier of the safety data sheet
Supplier Identification

Dharmacon Inc.,
Horizon Discovery Ltd.

Address

2650 Crescent Drive Suite 100
Lafayette, CO 80026

TelephoneTel: 303-604-9499
Fax: 303-604-9680

E-mailtechnical@horizondiscovery.com

Emergency telephone number
Company Emergency Phone
NumberChemtrec International: 1-703-741-5970_____________________________________________________________________________________________

Page 1 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

2. HAZARDS IDENTIFICATIONClassification
Classification under 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Each viral particle stock contains a pure recombinant, replication-defective lentivirus population. Lentiviral vectors are considered
GMO’s. The viral particles are classified as Risk Group 2 by the World Health Organization (WHO) and Biosafety Level 2 (BL2) or
Enhanced BL2 (depending on the circumstances) by the U.S. Centers for Disease Control (CDC) Office of Health and Safety.

Appearance Yellow

Physical state Liquid

Odor No information available

GHS Label elements, including precautionary statements

Hazard statements
Other information

3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance

Chemical name

CAS-NoWeight-%Lentiviral Particles
DMEM

XXX-XX-X
N/A

1-99%
1-99%

Hazardous Material
Date HMIRA filed andInformation Review Act date exemption granted
registry number (HMIRA(if applicable)
registry #)-4. FIRST AID MEASURESFirst aid measures
Inhalation

Remove to fresh air. (Call a physician if symptoms occur).

Eye contact

Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids.
Consult a physician.

Skin contact

Wash off immediately with plenty of water for at least 15 minutes. Get medical attention
immediately if symptoms occur.

Ingestion

DO NOT induce vomiting. Get immediate medical advice/attention.

Most important symptoms and effects, both acute and delayed
Symptoms

No information available.

Indication of any immediate medical attention and special treatment needed_____________________________________________________________________________________________

Page 2 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

Note to physicians

Treat symptomatically.

5. FIRE-FIGHTING MEASURES
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and thesurrounding environment.

Large FireCAUTION: Use of water spray when fighting fire may be inefficient.

Unsuitable extinguishing media

Do not scatter spilled material with high pressure water streams.

Specific hazards arising from thechemicalNo information available.

Explosion Data
Sensitivity to Mechanical Impact None.
Sensitivity to Static Discharge None.
Special protective equipment for
fire-fighters

Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.

6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Personal precautions

Use personal protective equipment as required. Ensure adequate ventilation. Avoid contact
with skin, eyes or clothing.

Methods and material for containment and cleaning up
Methods for containment

Prevent further leakage or spillage if safe to do so.

Methods for cleaning up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

7. HANDLING AND STORAGE
Precautions for safe handling
Advice on safe handling

Handle in accordance with good industrial hygiene and safety practice.
Wearpersonalprotective equipment. Ensure adequate ventilation. Avoid contact with skin,eyes and clothing. Avoid ingestion and inhalation. This material should be handled at thebiosafety level 2 (BSL2) as required by OSHA Bloodborne Pathogen Rule (29 CFR
1910.1030.7).

Conditions for safe storage, including any incompatibilities
Storage Conditions

Keep tightly closed in a dry place. Keep at -80°C.

_____________________________________________________________________________________________

Page 3 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Exposure Limits

This product, as supplied, does not contain any hazardous materials with occupational
exposure limits established by the region specific regulatory bodies.

Appropriate engineering controls
Engineering controls

Showers
Eyewash stations
Ventilation systems.

Individual protection measures, such as personal protective equipment
Eye/face protection

Safety glasses with side shields are recommended for medical or industrial exposures.

Skin and body protection

Wear suitable protective clothing.

Respiratory protection

No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.

General hygiene considerations

Handle in accordance with good industrial hygiene and safety practice.

9. PHYSICAL AND CHEMICAL PROPERTIES
Physical and Chemical Properties
Physical stateAppearance
Odor
Color
Odor Threshold

LiquidYellow
No information available
No information available
No information available

Property
ValuespH
No data available
Melting / freezing point
No data available
Boiling point / boiling range
No data available
Flash Point
No data available
Evaporation Rate
No data available
Flammability (solid, gas)
No data available
Flammability Limit in Air
Upper flammability limit
No data available
Lower flammability limit
No data available
Vapor pressure
No data available
Vapor density
No data available
Relative density
No data available
Water Solubility
No data available
Solubility(ies)
No data available
Partition coefficient: n-octanol/water No data available
Autoignition temperature
No data available
Decomposition temperature
No data available
Kinematic viscosity
No data available
Dynamic viscosity
No data available

Remarks Method
None known
None known
None known
None known
None known
None known
None known

None known
None known
None known
None known
None known
None known
None known
None known
None known
None known

Other Information_____________________________________________________________________________________________

Page 4 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

Explosive properties
Oxidizing properties
Softening Point
Molecular Weight
VOC Content (%)
Liquid Density
Bulk Density
Particle Size
Particle Size Distribution

No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available

10. STABILITY AND REACTIVITY
Reactivity

No information available.

Chemical stability

Stable under normal conditions.

Possibility of Hazardous Reactions None under normal processing.
Hazardous Polymerization

Hazardous polymerization does not occur.

Conditions to avoid

Excessive heat.

Incompatible materials

None known based on information supplied.

Hazardous Decomposition Products None known based on information supplied.

11. TOXICOLOGICAL INFORMATION
Information on likely routes of exposure
Product Information
Inhalation

Specific test data for the substance or mixture is not available.

Eye contact

Specific test data for the substance or mixture is not available.

Skin contact

Specific test data for the substance or mixture is not available.

Ingestion

Specific test data for the substance or mixture is not available.

Information on toxicological effects
Symptoms

No information available.

Numerical measures of toxicity
Acute Toxicity

Unknown acute toxicity

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation

No information available.

_____________________________________________________________________________________________

Page 5 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

Serious eye damage/eye irritation

No information available.

Respiratory or skin sensitization

No information available.

Germ cell mutagenicity

No information available.

Carcinogenicity

No information available.

Reproductive toxicity

No information available.

STOT - single exposure

No information available.

STOT - repeated exposure

No information available.

Aspiration hazard

No information available.

12. ECOLOGICAL INFORMATION
Ecotoxicity

The environmental impact of this product has not been fully investigated.

Persistence and Degradability

No information available.

Bioaccumulation

There is no data for this product.

Mobility

No information available.

Other adverse effects

No information available.

13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Waste from residues/unused
products

Dispose of in accordance with local regulations. Dispose of waste in accordance withenvironmental legislation.

Contaminated packaging

Do not reuse empty containers.

14. TRANSPORT INFORMATION
DOT

Not regulated

TDG

Not regulated

MEX

Not regulated

ICAO

Not regulated_____________________________________________________________________________________________

Page 6 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

IATA
UN Number
Proper Shipping Name
Hazard Class
Subsidiary classNot regulated
UN3245
GMMO
9
III

IMDG

Not regulated

RID

Not regulated

ADR

Not regulated

ADN

Not regulated

15. REGULATORY INFORMATION
Safety, health and environmental regulations/legislation specific for the substance or mixtureInternational Regulations
Ozone-depleting substances (ODS) Not applicable
Persistent Organic Pollutants Not applicable
Export Notification requirements Not applicable
International Inventories
TSCA
DSL/NDSL
EINECS/ELINCS
ENCS
KECL
PICCS
AICS

Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.
Contact supplier for inventory compliance status.

LegendTSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances

US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any
chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372

SARA 311/312 Hazard Categories
Should this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriateclassifications. Under the amended regulations at 40 CFR 370, EPCRA 311/312 Tier II reporting for the 2017 calendar year willneed to be consistent with updated hazard classifications.
CWA (Clean Water Act)_____________________________________________________________________________________________

Page 7 / 8

Revision Date 25-Jul-2022_____________________________________________________________________________________________

Viral Particles

This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42)

CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive
Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level
pertaining to releases of this material

US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
This product does not contain any substances above threshold limits that are regulated by state right-to-know.

16. OTHER INFORMATION
NFPA

Health hazards 0

Flammability 0

Instability 0

HMIS

Health hazards 0

Flammability 0

Physical hazards 0

Prepared By

Dharmacon Inc.,
Horizon Discovery Ltd.
2650 Crescent Drive Suite 100
Lafayette, CO 80026

Revision Date

25-Jul-2022

Physical and Chemical
Properties Personal Protection X

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its
publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation,
disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specificmaterial designated and may not be valid for such material used in combination with any other materials or in any process, unlessspecified in the text

End of Safety Data Sheet_____________________________________________________________________________________________

Page 8 / 8