SAFETY DATA SHEET

Issuing Date

19-Aug-2010

Revision Date

Revision Number 1

1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE
COMPANY/UNDERTAKING
Product Code(s)Product Name

500 tests: 415182F, 1500 tests: 415184F-HistofineSimple Stain AEC Solution

Recommended Use

For In Vitro Diagnostics UseImporter-------Company
Nichirei Biosciences Inc.
6-19-20, Tsukiji
Cyuo-ku
Tokyo, 104-8402, Japan
TEL: +81-3-3248-2207
For further information, please contact
E-mail Address
Emergency Telephone
Number+81-3-3248-2207

2. HAZARDS IDENTIFICATIONDSD/DPDNot a hazardous substance or preparation according to EC-directives 67/548/EEC or 1999/45/EC
Classification
Hazard Symbols
Not dangerous
Most Important Hazards
No information available.

GHS/CLP
GHS - Classification
Not Hazardous

GHS Label elements, including precautionary statements
Physical Hazards_____________________________________________________________________________________________
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None

Precautionary Statements
Prevention• None3. COMPOSITION/INFORMATION ON INGREDIENTS
Chemical Name

EC-No

CAS-NoWeight %Classification

Dimethyl sulfoxide-67-68-5

1.5-2.5

Xn;R22
Xi;R36/38

EU - GHS
Substance
Classification
Skin Irrit. 2 (H315)
Eye Irrit. 2 (H319)

REACH No.

No data available

For the full text of the R-phrases mentioned in this Section, see Section 16

4. FIRST AID MEASURESEye Contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

Skin Contact

Wash off immediately with soap and plenty of water removing all contaminated clothes andshoes.

Ingestion

Clean mouth with water and afterwards drink plenty of water.

Inhalation

Move to fresh air.

Notes to Physician

Treat symptomatically.

5. FIRE-FIGHTING MEASURES
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Extinguishing media which must not be used for safety reasons
No information available.
Special exposure hazards arising from the substance or preparation itself, combustion products, resulting gases
None in particular.
Special protective equipment for fire-fighters
As in any fire, wear self-contained breathing apparatus and full protective gear.

6. ACCIDENTAL RELEASE MEASURES
Personal Precautions

Ensure adequate ventilation.

Environmental Precautions

Prevent further leakage or spillage if safe to do so.

Methods for Cleaning up

Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder,sawdust).

Other Information

See Section 12 for additional information.

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7. HANDLING AND STORAGE
Handling

Ensure adequate ventilation. Prevent contact with skin, eyes and clothing Wear personal
protective equipment.

Storage

Keep container tightly closed in a dry and well-ventilated place.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Exposure Limits
Chemical Name
Dimethyl sulfoxide
67-68-5

EUThe United Kingdom

FranceSpain

Germany
MAK: 160 mg/m3
MAK: 50 ppm
Ceiling / Peak: 100 ppm
Ceiling / Peak: 320
3mg/m
Skin

Chemical Name
Dimethyl sulfoxide
67-68-5

Italy

Portugal

The Netherlands
Skin
MAC: 50 ppm MAC;
150 mg/m3 MAC

Finland
TWA: 50 ppm
Skin

Denmark
TWA: 160 mg/m3
TWA: 50 ppm

PolandNorwayIreland

Chemical Name
Dimethyl sulfoxide67-68-5Austria
Switzerland
Skin
Skin
MAK: 50 ppm MAK; 160 MAK: 50 ppm MAK; 160
mg/m3 MAK
mg/m3 MAK

Occupational Exposure Controls
Engineering Measures

Ensure adequate ventilation, especially in confined areas.

Personal Protective Equipment
Eye Protection
Hand Protection
Skin and Body Protection
Respiratory Protection

Safety glasses with side-shields.
Protective gloves.
Long sleeved clothing.
When workers are facing concentrations above the exposure limit they must use appropriate
certified respirators.

Hygiene Measures

Handle in accordance with good industrial hygiene and safety practice.

Environmental Exposure Controls

No information available

9. PHYSICAL AND CHEMICAL PROPERTIES
General Information
Physical State
LiquidOdor
AceticImportant health safety and environmental information
Flash Point
pHVapor Pressure
Viscosity
Evaporation Rate

No information available.
5.2
No information available
No information available
No information available

Flammability Limits in Air

No information available.

Other information
Melting Point/Range

No information available.

Appearance

Colorless

Boiling Point/Range
Autoignition Temperature
VOC Content (%)
Specific Gravity
Vapor Density

No information available.
No information available.
No information available
No information available
No information available.

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10. STABILITY AND REACTIVITY
Stability

Stable under normal conditions.

Conditions to Avoid

Heat, flames and sparks.

Materials to Avoid

None in particular.

Hazardous Decomposition
ProductsNone under normal use.

11. TOXICOLOGICAL INFORMATION
Acute Toxicity
Product Information

Product does not present an acute toxicity hazard based on known or supplied information.

Inhalation

No known hazard by inhalation

Eye Contact

No known effect.

Skin Contact

Causes mild skin irritation

Ingestion

No known effect.

Chemical Name
Dimethyl sulfoxide

LD50 Oral
14500 mg/kg ( Rat )LD50 Dermal
40 g/kg ( Rat )LC50 Inhalation

Chronic Toxicity
Carcinogenicity

Contains no ingredients above reportable quantities listed as a carcinogen.

Target Organ Effects

None known.

12. ECOLOGICAL INFORMATION
Ecotoxicity

Chemical Name
Dimethyl sulfoxide

Toxicity to Algae
EC50: 12350 - 25500 mg/L
Skeletonema costatum 96 h

Toxicity to Fish
Toxicity to Microorganisms Daphnia Magna (Water Flea)
LC50: 34 mg/L Pimephales
EC50 = 16000 mg/L 16 h
EC50: 7000 mg/L Daphnia
promelas 96 h
EC50 = 32 g/L 24 h
species 24 h
LC50: 33-37 g/L
EC50 = 77 mg/L 5 min
Oncorhynchus mykiss 96 hstatic
LC50: >40 g/L Lepomis
macrochirus 96 h static
LC50: 41.7 g/L Cyprinus
carpio 96 hPersistence and Degradability

No information available.

Bioaccumulative Potential

No information available

Mobility

No information available
Chemical Name
Dimethyl sulfoxide

Log Pow-2.03_____________________________________________________________________________________________
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13. DISPOSAL CONSIDERATIONS
Waste from Residues/Unused
Products

Dispose of in accordance with local regulations.

Contaminated Packaging

Empty containers should be taken to an approved waste handling site for recycling or disposal.

14. TRANSPORT INFORMATIONIMDG/IMO

Not regulated

RID

Not regulated

ADR

Not regulated

ICAO

Not regulated

IATA

Not regulated

15. REGULATORY INFORMATIONDSD/DPD
Not a hazardous substance or preparation according to EC-directives 67/548/EEC or 1999/45/ECLabeling
EU Labeling
Safety data sheet available for professional user on requestSymbol(s)Not dangerous

R-phrase(s)No information available.
S-phrase(s)No information available.

GHS/CLP
Signal Word

Not Hazardous

International Inventories
All of the components in the product are on the following Inventory lists:(EINECS/ELINCS/NLP), Korea (ECL), Philippines (PICCS).
TSCA
EINECS/ELINCS

U.S.A. (TSCA), Canada (DSL/NDSL), Europe

Complies
Complies_____________________________________________________________________________________________
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DSL/NDSL
PICCS
ENCS
IECSC
AICS
KECL

Complies
Complies
Does not comply
Does not comply
Does not comply
Complies

LegendTSCA - United States Toxic Substances Control Act Section 8(b) Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified Chemical Substances
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances

RESTRICTIONS - REACH TITLE VIII

No information available.

16. OTHER INFORMATION
Full text of R-phrases referred to under Sections 2 and 3
No information available
Issuing Date

08-Sep-2010

Revision Date
Revision Note

Not applicableThis safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
General Disclaimer
The information provided on this SDS is correct to the best of our knowledge, information and belief at the date of its
publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation,
disposal and release and is not to be considered as a warranty or quality specification. The information relates only to thespecific material designated and may not be valid for such material used in combination with any other material or in any
process, unless specified in the text
End of Safety Data Sheet_____________________________________________________________________________________________
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