BRIEF SUMMARY
Th e Nation a l In sti tut e for Basic Biology, NIBB, is a part of a
new ly- estab lish ed research orga ni zat ion, the Okazaki Nat iona l
Research Institutes located on a hill over look ing the old town ofOkazaki. Th e research institute is composed of three indep ende nt
organizations, National ln st1tute for Basic Biology, National Institutefor Physiological Sc iences and In stitute for Molecular Science.
NIBB is an interuniversity research In sti tut e w ith its own
intr am ur al research programs as we ll as coope rati ve programs topromote bas1c biology in Japan. The programs are 1) joint
research programs in which university scientists are in v ited t opartic ipate in research projects w it h the intramura l members,
2) facility-sharing programs in which university sc ie nti st s utilize
the in st itut e's research resources, 3) graduate st udent
tr ainin g programs in which graduate students from un 1ve rsiti es spend
fi xed periods of time w1th th e NIBB, and 4) internat iona l programs
in whic h fore1gn sc ientists are invited t o NIBB to conduct
research proJects

DR . T.S . OKADA

2INTRODUCTION
The National In stitute for Basic Biology (N IBB) aims
to facilitate the basic resea rches in biological sc iences
1n Japan by conduct ing the most advanced studies toeluc id ate seve ral fu ndamenta l mechanisms underly ing
li ving organ isms Research areas inc lude control
mechanisms in reproduct ion. cell division andd ifferen t iation. biologica l rhythm s. photobio logy andvision physiology. Analytica l approaches range from themolecula r to organismic leve ls of o rgan ization.
For many years th ere has been a ser ious desire.
among Japanese biolog ists. to have a nat iona l research
cen ter for bio logy. Th e desire materialized in May 1 977
when Di et passed a bill to authorize the NIBB in
Okazaki. a ci ty close to Nagoya in the cen t er of theJapanese arc hip elago. At the same time. a sister
institute. the National lnsti t wte for Physiologi ca lSciences. also a lon g awaited. was approved. The two
institutes col laborate close ly. sharing many import ant
facilities but keepi ng their own identity.
Th e NIBB . which is an interuniversity research
institute and is sti ll under development. has a two-foldmission: to conduct researches by its own staffs andthose by col labo ration w ith sc1e ntis t s o utside NIBB . Th e
former m ission is discharged by the 13 divisionsorganized into three depar tm ent s. the Departments ofCell Biology. Deve lopmenta l Biology. and Regu lation
Biology. Each division has a fu ll p ro f esso r and an
associate professor and two rese arch assoc iates. Of the
13 d iv isions. 6 are for adj un ct professorships with joint
appo intm ent wi th oth er institutes in Jap an. For th e latter

mission. the NIBB sponsors joint research programs wi th
participating md1v1duals or research groups throughout
Japan.
The NIBB p1·ov ides research resources to be shared
among biologists in Japan as well from abroad The
NIBB sponsors sympos ia on up-to-date topics at themterd1SC1pl1nary level by inviting leadin g scient ists from
related f1elds both from inside and outside Japan. Thus.
the NIBB expects to cont ri bute the progress inbiological sc1ence nationally as well as internationa l ly .

T.S Okada. D.Sc i.
Director General
National Institute f or Basic Biology.

3

ORGANIZATION OF THE INSTITUTE
Policy and Decision Making
The Director General oversees the operation of the instituteass ist ed by two adv isory bodies. the Adv isory Counc il andSteering Counc il . The Advisory Council is made up ofd istinguished scholars represent ing various fi elds of sc ience and cu lture and advises th e Dir ec tor General on thebas ic policy of the institute. The Steering Council is madeup of professors of the institute and an equal numberof professors from other leading universities in J apan
and advises the Director Genera l on the scientificactivities. intramura l as well as extr amural. of the i·nstitute.
The Counc il advises on faculty appointments and on
th e institut e's annual budget

Administration
Adm ini stration of the institute 1s undertaken by the
Administration Bureau of the Okazaki National ResearchInstitut es under the direct auspices of the Ministry of
Education. Science and Culture. Currently the ch 1ef administration officer is Mr. Akira Muroya (-Nov 1984) [Mr.
Katsuh iko Kurioka (Dec 1 984- )].

4

professors who hold JOint appointment wit h other universi ties.
Th e adjunct division has resident research associates. The
arrangement aims to facilitate exchange of research activities
in JapanTec hnical D epa rtm ent manages the activities of researchtechniques and help to promote research activities of eachd ivision and also to maintam the research resources of theinstitute. The department undertakes the technical educa t ionof its staff.

Research Support Facility
Th e intramural res ea rch support fac ility of NIBB includes theLarge-scale Spectrograph Laboratory. T1 sue and Cell Culture
Labo ratory. Laboratory Computer Facil it y. Plant Culture
Facility. Plant Cell Culture Facility. and Experimental Farm. In
addition. seven facilities are operated jomtlywith the National
Institute of Physiological Sciences; they include Radioisotope
Facility. Electron M1croscope Center. Center for Analytical
Instruments. Machine Shop. Glassware Cleaning Facility.
An1mal Care Facil ity. and Low-Temp erature Facility.

Research

CampusTh e insti tu te conducts it s intramural r esearch programs
through three depa rtments organized into 1 3 d ivisions. Eachdivision has it s own re sea rch project and is staffed by aprofessor. an assoc1ate p rofessor and two researc h associates. A division forms a project team and is expec t ed to bereorganized when a division's p roject is completed Ha lf of thedivisions are for ad Junct professorship and are underTh e Okazaki National Res ea rch Institutes cover an area of
1 50.000 sq m. with four principa l buildings. The NIBB's main
research building has a floor space of 10 .930 sq.m. Tw othirds of the space had been completed by 1 982 and theremaining third was constructed by June. 1983 The
buildings to house research support facility was also
complet ed by June. 19 83.

DEPARTMENT
OF CELL BIOLO GY
Chairman :Yoshihiko Fujita

Th e department IS formed by two research divisions and thr ee
adj un ct research d1visJOns and conducts resea rch on th efund amentals of structur e and function of cells at molecula rleve l.

Division of Cell Mechanism s
Professor : Tsuneyoshi Kuroiwa
Associate Professor : Toshiyuki Nagata
Research Associate : Shigeyuki Kawan o
Kazuo Ogawa
Uslllg va r1 ous cell bJologJca l app roac hes. research in thisdivis1on IS des1gned to study the mechanisms o f Inheritanceand prol iferation of sem 1au tono mous o rg an ell es lik e mitochondria and chloroplas ts . Th ese organe ll es conta in spherica lo r rod-shaped organelle nucle1 compose d of DNA. RNA andprot eins wh1ch are dup li cated during o rgane ll e-nuc lea rdivision Soon after matlllg of female a nd mal e gametes. t hechlo roplast nucle1 of male o r1 gi n disappea r preferentia lly
w h1l e those of female o r1g1n pers1s t and a1·e tr ansmitted t o
p r oge ny . Pr oba bly thi s is a ce llular mecha ni sm o f mat e rnal
inhe1·itance of organelles M a111 proJects in our divi s ion
in vo lve clarification of the molecu lar basis f o r mitochondria nuc lea r d iv iSIOn and for preferen tial des tru cti on of malech lo roplast nucle1.

Division of Bioenergetics
Professor : Yoshihiko Fujita
Associate Professor : Shigeru ltoh
Research Associate
Mamoru Mimuro
Kaori Ohki
M echan ism of biol og ical e nergy c onver s io n in pho tosyn th esis has been investi ga ted Sp ec ia l atten ti on has bee npaid t o th e mec hani sm of li ght-captu ring and e nergy transfer
i n th e photosynt heti c pi gment sys t em a nd th e m ec hani sm ofene r gy conversion. f r om elec tric to biochem ica l. in theth ylakoid memb ra nes. M o l ec ul ar architectu re and ene r gy
fl ow 1n phycob 1l1n system of red and b lu e-g ree n algae are themain targets in th e form er: m echa ni sm of c hr oma tic
adapta t ion o f the pigment system has been also studi ed . Th emain f oc us in th e latt er is th e memb ra ne pot e nti al fo rm ati on
drive n by elec tron f low 1n t hyl akoid memb ran es: electron fl ow
m ec hani sm itself has been also stud1ed with specia l atten tion
to th e Orevo lvi n g syst em.

Division of Cell Fusion (Adjunct)
Professor : Yoshio Okada
Associate Professor : Masaru Yamaizumi
Research Associate : Masahiro lshiura
Kenji Kohno
Bi o logy and ge net ics of cultu red mammalian ce lls 1n c lud 1n g
hu ma n ce lls. util izing ce ll eng in eer 1n g t ec hni q ues base d on
ce ll fusi o n phenomenon by HVJ (Senda i vi ru s) andmi c ro o rga n1 sms o r th ei1· derivatives are p r oposed as t h eresearch pr oje cts for this Oiv ison.

5

Division of Cellular Communication(Adjunct)
Professor : Yasutomi Nishizuka
Associate Professor : Yoshimi Takai
Research Associate : Keisuke Hirasawa( ~ Jun. 1984)
Cellular function and proliferation are frequent ly act iva ted byinteraction of extracellular messengers w ith specific ce llsurface receptors. and the mechanism of such act ivat ion.
particul ar of transmiSSIOn of information across the cellmemb rane has attra cted great attention. The ma Ill p roJect
currently under way in this divis ion is to explore the molecularbasis of hormone actions as we ll as of other ce ll to cellcommunication. Along this lin e an en tir ely new receptor
fun cti on ha s been recently uncovered. The funct1on 1s
indep end ent of cyclic nucleotides but is directly coupled top ho sp hati dylinos ito l turnover provoked by va rious extracel lul ar
s1g nals. Calcium. together w 1th dig lycer ide derived f rom th1 s
phospholipid tur nover. specifical ly activates a multifunctional
prote in kinase which p lays ro les of crucial importance forcon tr o llin g a w id e var iety of cel lul ar activities through p rotein
phosphoryl at1 on

Division of Cell Prolifer.ation (Adjunct)
Professor : Yukio Hiramoto
Associate Professor: Issei Mabuchi
Research Associate: Yasuaki YoshimotoTh e di vision conducts research on the mechanism of cel ldivision and th e cell cyc le through physiolog ical. bi oc hemi ca land morphol og ic al approaches M a 1n prOJects are to exp lore
mechanisms of the synthesis of proteins and nucl e ic ac ids
at various stages of ce ll cyc le. th e form ation of th e mit o-6

tic apparatus.
cytokinesis.

themovementof c hromosom es and the

DEPARTMENT
OF DEVELOPMENTAL
BIOLOGY
Chairman :Goro Eguchi

Th e depa rt ment IS composed of three research divisions andone adJunct research div1sion. and conduc ts researc h 1nto th ece llul ar a1ld molecula r mechanisms of var ious processes
which are involved 1n deve lopmen t a l phenome na

Division of Reproductive Biology
Associate Professor :Research Associate :Yoshitaka Nagahama
Hiroko Shirai
Takeo KishimotoTh e d1vision cond u cts research into two maJOr areas o f th e
repr od uc tiv e process ( 1) th e ce llul ar an d molecular mechanism s of f orma ti on and re lease of gametes. particularly th ehorm o na l co ntrol of oocyte maturation and ovulation. and(2) mechanisms involved 1n fertilization. Th ese studies
co mbin e biochemical. fine st ru ct ur al and physiolo g ical
approaches.
Research cen t ers a round oocyte maturation in starfish In thisin ve rt ebrate spec1es a hormonal substance. go nad-s timul at In g substa n ce (GSS) sec reted by the rad ial ne rves . acts on theova ri an follicle ce ll s to produce a seco nd m ed iator of
matur at ion. matu rati o n -indu c in g subs t ance (MIS). 1 -me thyl adenine ( 1 - M eAde ) 1 -M eAde ac ts on th e surface of th eoocytes to induce formation of the third mediator of
maturatron within the oocytes. maturat ion-promoting factor(MPF) which brings about germinal vesicle breakdown.
Current research is as follows ( 1) the characterizat ion andsynthesis of GSS. (2) the mechanisms of biosynthesrs of 1MeAde in the ovarian follicle cells. (3) the isolation andidentification of the 1-MeAde receptor located on the oocyte
surface. (4) the characterization and function of MPF. and(5) fertilization rn echinoderms the role of divalent cations
and jelly substances in the acrosome reaction.
In addition. the endocrine control of oocyte vitellogenes is andmaturation in teleosts is under investigation. Particularattention has been given to ( 1) the purification of teleost
gonadotropins. (2) the mechanism of gonadotrop in action.
(3) the identification of teleost MIS. and (4) the role of thedifferent ovarian follicle layers in the production of estrogens
and M IS.

Division of Cell Differentiation
Professor : Yoshiaki Suzuki
Associate Professor : Susumu Hirose
Research Associate : Masaaki Tsuda
Yoshihide Tsujimoto

The division conducts a research on the molecular basis ofcel lul ar differentiation with a special emphasis on regulatory
mechanisms of tissue-specific genes. The major targets are
fibroin and seric in genes which are expressed at spec ifi cstages of development in the posterior and middle portions ofsilk glands of the si lkworm Bombyx man. respectively.
Employin g th e gene manipulation technology the members
do "in vitro genetics": isolation of the target wi ld-type genes.
p reparation of des ir ed mutant genes from the wi ld-typ ege nes. and in vivo and/o r in vitro t ests of biological funct rons

for the wild-type and mutant genes. They ultimately hope tounderstand the regulation machinery of the tissue-specificgenes through a reconstructed system wh ich reflects thestates of in vivo regu lat ion. For the study of in vivo tests ofbiological functions. impr ovements of the introduction offoreign DNAs rnto living cells are being pursued They havesucceeded in establishing a cell-free transc ripti on sys t em
prepared fr om the si lk gland ce ll s. Use of this system hasrevealed the promoter signal and the transcription enhancement signals of the fibro in gene.

Division of Morphogenesis
Professor : Goro Eguchi
Research Associate : Ryuji Kodama
Kiyokazu Agata

Mechanisms of differentiation and morphogenesis in multicellular organization have been investigated at cel lular andmolecular levels. Th e research has been currently focused on
the following three proJects. ( 1) The ce ll culture expe rim enta lsystem of chick embryo pigment epithelial cells (PECs) has
been estab li shed. This system can produce a mult ipotential
dedifferentiated state of PECs. which is able to redifferentiate
to lens cells or pigment cells. By this system environmenta lfactors controlling the transdifferentiation have been analyzed.
particularly focussing on the structural and functiona lchanges of ce ll surface relating to dedifferentiation andredifferentiation of the PEC. The molecular mechanism ofspecific gene expression has also been analyzed in the same
system. (2) The mechanrsms of pattern formation andstab ili zation of two dimensional epithelial tissue structures
have been investigated in vivo as well as in vitro experimenta lsystems by computer graphics. electron microscopy, micromanipulation and biochem ical techn iqu es. Such approaches7h ave also bee n extend ed t o an alyze mo rp hoge n esi s of thr ee
di men siona l ti ss ue stru ctur es. (3 ) In add iti o n t o th ese two
pr ojec ts. analysi s of c ell l1n eage 111 ea rly m amm a l1 an
deve lo pmen t has bee n con d uc ted by means of w ho le em b ryo
c ult ure tec hniq ue . wh 1c h a ll ows a fe rtil1 ze d m o u se egg todeve lo p 1nto th e som ite st ages

Division of Developmental Biology(Adjunct)

DEPARTMENT
OF REGULATION BIOLOGY

c harac teri sti cs of retin al n eur o ns and n euro n cha in s. Th e 16y ea r o ld resea rc h was o ri g in at ed at t he Calif. lnst . Tec h. andcarri ed o ut at Univ. Tex as M edi c al Br anch at Galve st on befo re
it w as move d t o thi s new in st itut e. Th e di v isi on is also
pl anni ng t o ap p ly th e meth o d o lo gy deve lo ped in c hann el
c atfi sh to st udy c han ge s in th e fun cti o n al mo rp ho log y ofd eve loping retin as.

Division of Chronobiology
Associate Professor : Hideaki Nakashima
Research Associate : Takao Kondo

Th e departmen t has two d iVISions and two ad j u nct divis io ns
and cond ucts resea rch on the info rma ti on p rocessing andcon tr o l mec han is ms in b io log ica l sys t em s.

Th e d ivisio n aim s t o cl arif y th e mo lec'ul ar structur e andp hysio logica l fu nct ion of t he endogenous c 1r ca di an rh yt hms(b io logical c locks)
At th e moment. t he geneti c andb i oc hem ica l an alyses of t he Neurospora cloc k wh 1ch
co ntr ols t he co nidi ation rhy t hm and ph ys io lo g1ca l andbioche mi ca l stu d ies of th e duckweed (Lemna gibba and L
pauctcostata) clock as related wi t h t he p ot assi um upt aker hyth m are the t wo maJOr th emes of resea rc h .

Division of Sensory Processing

Division of Biological Regulation (Adjunct)

Chairman :Yoshihiko Fujita (acting)

Professor : Ken-ichi Naka
Associate Professor : Syozo Yasui
Research Associate : Hiroko Sakai
Eiki Hida
Th e division co nd uct s resea rc h o n t he info r mation processin g in th e v isual syste m through an in terd isc ip li na ry
ap pr oac h w hi c h in c lu des tr aditi o nal m o rp ho lo gy and p hy siology, as we ll as no nlm ea r (w hite-no ise ) ana lys is andmo d ellin g. Th e main thru st of resea rch IS th e f un ct1 o nal
m orph ology of th e retin al of c hann el ca tfi sh. lc taluruspunctatus. and id entifi ca ti o n of spati a- t em po ral filt erin g

Professor : Masaki Furuya
Associate Professor : Yasuhiro Miyoshi( ~ Mar. 1984)
Katsushi Manabe(Apr. 1984 ~ )Research Associate : Kotara Yamamoto
Satoru Tokutomi
Th e resea rc h i n t h is d iv isio n aim s to stud y t he reg ul at o ry
m ec hani sms of bio log ica l func ti ons at mo lec ul ar ands ub ce llul ar leve ls. The resea rc h p rog ram s p roposed andb ein g ca rri ed o ut at p rese nt ce nter aro und th e ea rl y c hanges

9induced by env ironmental stimul i f irst physical and chem ical
characterization of phytochrome. a photoreversib le chromoprotein that mediates plant development; second. the pr imary
act ion of photoreceptors regulating funct ions of bio log ical
membranes; third. ident ification of chemically unknown
pigments such as the blue and near-u ltraviolet lightabsorbing pigment that control seve ral photob io log ical
processes. a green light absorbing pigment controll ing
phototaxis. and others which have been. and wi ll be indica t edin the results obtained with the LARGE SPECTROGRAPH here.

Division of Behaviour and Neurobiology(Adjunct)
Professor : Keiichi Mimura
Associate Professor : Tateo Shimozawa
Research Associate : Teiichi Tanimura
The division conducts research on the invertebrate behaviour
through neurobio logical approach which includes electro physiology. morphology. and behavioural and genetic
analysis. The division attempts to progress our researches
through the following three ways First insect vision.
especially neuronal mechanisms of the fly visual system. areinvestigated by electrophysiolog1cal. morphological. biochemical and behaviora l methods The second proJect
intends to reveal the molecular mechanisms of taste 1n the
fruit f ly. Drospohila melanogaster. employing genetic methods. The approach includes electrophysiological andbiochemical ana lyses of various mutants in sugar responses.
The neural mechanisms underlying feeding behaviour is also
a subject for study Third. neuronal networks responsible fort he generation of motor programs- e.g. righ t ing behaviour.
stridulation. and locomotion of crickets are i nt erested.
Particularly. analysis of the mechan isms invo lved in the10. se lect ive recruitment of motorneurons is intended by meansof microelectrodes. intracellular dye tracers and elect ron
microscopy.

TECHNICAL DEPARTMENT
Chief : Hachiro Honda
The Technical Department is a supporting organization
for researchers and research organizations within the NIBB.
The department develops and promotes the Ins t itute's
research activities and. at the same time, ma intains t heresearch functions of the institute.
The Department is organized into two groups . one. theCommon Facility group. which supports and maintains theinstitute's common research facilities and the other. theResearch Support group. which assists the intramura lresea r ch activities
Techn1cians participate. through the department inpromot1ng their capability through mutual enl1ghtenment andeducation so that the ir capabi lity in technical area develops.

Hachiro Honda
Manager :Staff :
Common Facility Group
Laboratory Computer Facility:
Yuichiro Ando
Large- Scale Spectrograph Laboratory:
Mamoru Kubota
Experimental Farm :Chieko Nanba
Radioisotope Facility:Kazuhiko Furukawa
Yukie ShinoharaCenter for Analytical Instruments:
Hiroyuki Hattori (Chief)
Hiroko Kajiura
Hisashi Kojima
Glassware Cleaning Facility:
Toshiki Ohkawa
Research Support Group
Department of Cell Biology:
Akio Murakami
Soichi Nakamura
Department of Developmental Biology:
Satoko Adachi
Shinji Adachi
Hisayo Kondo
Shigeharu Takiya
Department of Regulation Biology:
Yohko Fujimura
Soh Hidaka
Masahiro Nasu

RESEARCH RESOURCE
Th ere are f our categories of research support fac iliti es
available to the intramural as wel l as to the visiting biologica lscien ti sts: 1) Campus-wid e fa c ilitie s (CENTRAL COMPUTINGCENTER and LIBRAR Y), 2) NIBB's own research support
facilities (RESEARCH SUPPORT FACILITY, intramura l). 3)
facilities jo intly maintained by the NIPS and the NIBB but
managed eithe r by the NIPS (ANIMAL-CARE FACILITY) o r by
the NIBB (RAD IOISOTOPE FAC ILITY). 4) facilities j oint ly run
by NIPS and NIBB (CENTER FOR ANA LYTICAL INSTRUMENTS.

ELECTRON MICROSCOPE CENTER. GLASSWARE CLEANINGFAC ILITY. MACH INE SHOP and LOW-TEMPERATURE FACILITY)RESEARCH SUPPORTFACILITY (INTRAMURAL)
Head of Facility : Ken-ichi Naka
Faculty : Masakatsu Watanabe (Spectrograph)
Yoshio Hamada (Tissue and Cell Culture)
The faci lity maintains large-scal e experimental equipment
and facilit ies for growing and maintaining biological
specimens. Th e faci lity is shared by th e intramura l members
and have six laboratories.
Th e Large-Scale Spectrograph Laboratory: Th is laboratory
has the larg es t spectrograph in the world custom-bu ilt by
Naka works. Hitachi Ltd. The spectrograph runs on a 30 KWXenon arc lamp and has a compound grating-surface
composed of 36 smaller tndividual grating. A computer
controls th e positioning and tim e-sc hed ul ed light exposuresof 1 2 specimen boxes.
Tissue and Cell Cu lture Laboratory This is a facility fortissue and ce ll culture. This laboratory is equipped wi th safety
rooms which satisfy the P3 physical con t ainmen t leve l. Thisfa cil ity is routine ly used for DNA recombination experime nt s.
Labor atory Computer Facility: The NIBB's computing ishandl ed by a Digital Equipment Corporation's VAX-11 /780
computer w ith a Floating Point System AP120B arrayprocessor and a Spatial Data image digitizer. An extensive
software system for time-series analysis is available as wel l as .
a limited number of ima ge processing routines.
Plant Cu lture Facility:

Ther e are a large number of cu.lture11

boxes and cubicles and a limited number of rooms withenv ironmental control for plant cu lture
Experimental Fa rm This facility consists of 2 20 sq.m.
glass-houses with precision temperature and humidity
control. a limited farm. a large (88-sq.m.) and a small (45sq.m.) green house with automatic sprinklers and window
control. two (30- and 50-ton) open aquanums and seve ral
smaller tanks. The facility also includes a building with off1ce.
storage and work-space.
Plant Cell Culture Facility Autotrophic and heterotrophic
culture d evices are equipped for experimental cultures ofplant and microbial cells.

RESEARCH FACILITIESRADIOISOTOPE FACILITIES(managed by NIBB)Head of Facility : Yoshiaki Suzuki
Faculty : Kohji Hasunuma
The facility is composed of a center and two subcenters. one
in NIBB and other in NIPS. The facility is being used formolecular analyses of eukaryotes. At the center a variety of
rad ioisotopes such as 22 Na. 125 1. 32 P. 3 H and 14 C are handled aswell as various species of gamma-ray emitt ing nucleides. A
P3- level laboratory for recombinant DNA research is includedin the center facilities. At the substations. only a limited
variety of radioisotopes such as 3 H. 14 C and 32 P are processed.
The substation in NIBB is equipped with a P2- levelrecombinant DNA res ea rch laboratory. The members of theRadioisotope Facility maintain and control the cente rs. andgive users an appropriate guidance for radioisotope handling.
The faci li ty members conduct also the ir own research on the
ana lysis of mutants in the metabo lism of cyclic nuc leotides in

12

Neurospora crassa. The mutants exhibit several characterssuch as rhythm ic conidiation. sensitivity to l1ght. lack in th e
product i on of proteoperithecia and abnormality in meios is.
Th e goa l of the resea rch is to isolate and characterize thegenes for the regu lation of cyc lic nucleotides with DNA
recombination techniques

ANIMAL-CARE FACILITIES(managed by NIPS)
Vivarium Th1s is a 2.000-sq.m. building for (admitting andmaintaining) land an imals. including 1nsects. Operations andexper1ments of a limited scope may be performed in the
VIVariUm
Aquarium This is a 600-sq m facility for both fresh- andsea-water an1mals There are 10 ten-ton and 31 0.5-ton tanks
in addition to one seven-ton and one two-ton circular tanks.
All tanks are individually temp erature co ntrolled and aresupplied ei ther with deionized water or seawater. There is alorry with a one-ton temperature- co ntrolled tank to transport
aquatic animals and plant.

RESEARCH FACILITIES RUNJOINTLY WITH THE NIPSELECTRON MICROSCOPE CENTER
This facility maintains the following microscopes for the useof intramural members as well as researchers f rom otheruniversities and research institutions.
Transmission microscope
Hitachi H-500 125KV. JOEL
1 00-CX and 200-CX 100 and 200KV. and Phi lips EM400HM 1 20KV.
Transmission scope. analytica l JOEL 200-CX. 200KV.
Scanning scope: Hitachi S-450 25KV.

CENTER FOR ANALYTICALINSTRUMENTS
Head of Facility : Yoshihiko Fujita
The Center for Analytical Instruments consists of thefollowing five sections. ( 1) Chemical analysis. (2) Preparation of Biological Materials.. (3) Spectroscopic analysis.
(4) Physical analysis. and (5) Microscopic analysis. Eachsection is equipped with instruments for general use as listed
below.
1. Section for Chemical Analysis
Amino Acid Analyzer
HITACHI 835
HPLC
JASCO TRIROTAR Ill
Peptide Sequence Analyzer JEOL JAS-47K
Peptide Synthesizer
BECKMAN 990C
2. Section for Preparation of Biological Materials
Coulter Counter
COULTER ZB
lsotachophoresis System
LKB 2127 TACHOPHOR
Preparative Ultracentrifuge
BECKMAN L8-80
Two Parameter Cell Sorter
BECTON-DICKINSON
FACS-11
3. Section for Spectroscopic Analysis
Atomic Absorption
Spectrophotometer
PERKIN-ELMER 603
Defferential Refractometer
CHROMATIX KMX-16
Dual-wavelength,
Spectrophotometer
HITACHI 557
Infrared Spectrophotometer JASCO A-302
Laser-Raman
Spectrophotometer
JASCO R-800
Light Scattering Photometer CHROMATIX KMX-6DC
Spectrofluorometer
HITACHI MPF-4'~-. 1A-~. '

.;.

...

Spectrophotometer
Spectropolarimeter
4. Section for Physical Analysis
Ana lyti ca I Ultracentrifuge
Differential Scanning
Calorimeter
EPR Spectrometer
GC Mass Spectrometer
Superconductive FT-NMR
Spectrometer>'
Viscometer

GILFORD 250
HITACHI 330
JASCO J-40S
HITACHI 282
PERKIN-ELMER DSC-2
BRUKER ER 200D
HITACHI M-80
BRUKER WM 360 wb
CONTRAVES RM-30

5. Section for Microscopic Analysis
2-Dimension
M icrodensitometer
JOYCE LOEBL 3CS
Film Data Analysis System
NAC MOVIAS GP-2000
KONTRON MOP-AM03
Image Analyzer
Interactive Image Analyzer
KONTRON IBAS-1.11
Microscope Photometer
CARL ZEISS MPM 03-FL

COOPERATIVE RESEARCH ACTIVITIESThe NIBB sponsors four cooperat ive resea rch activities.
Individua l and group cooperative research program: Scientists from other Japanese
universities and research institutes are invited to undertake joint research projects with
the intramura l members. Limited funds are available for travel and expenditures related tothe projects.
Research conferences: The NIBB sponsors research conference on important subjects inbiology. Ten to twenty scientists are invited and intense discussion is he ld for two to threedays The NIBB provides financial support for the participants. Conferences may be
ini t iated by scientists with other institutes or by intramural members.
Faci lity-sharing program: Scientists with other universities are entitled to the use of
specified instruments maintained by the NIB B. No financial support is available except for
the Large Scale Spectrograph whose user is provided with limited financi al support.
Graduate student programs: Graduate students with other universities may spend a fixed
period of time with members of NIBB. This allows students to have experience with thevery modern faci lity of NIBB. The NIBB. however. does not have its own graduate program.

15

LIBRARY
The three institutes of the Okazaki National Research In stitutes share a common libraryfacility. T he library is a part of the ma in admmistration bui lding and has a floor space ofabout 2.4 78 sq.m.
The library has a stock of 9.350 books in Japanese and 30.050 in foreign languages
and subscribes to 237 Japanese and 446 for eign JOurnals Lending records. 1nventory.
and literature searches are computerized. The library is open 24 hrs every day.

LODGING FACILITYThe Okazaki National Research Institut es maintain two lodging facilities. one Mishima
Lodg e and the other Yamate Lodge. Mishima Lod ge is a few minute walk away: Yamate
Lodge is less than 20 minutes. The lodges are for scientists and their families staying f or
fixed periods of time with the institutes. Some suites and bungalows are provided withkitchenette facilities A modest charge is levied to help to mainta1n the facilities.
Mishima Lod ge has 2 7 sing le rooms. 3 su it es and 6 bungalows for large families.
Yamate Lodge has 11 single rooms. 4 suites and 2 family complexes.
On the campus there is a d1ning facility wh1ch is open Mo1lday through Saturday.

16

THE CITY
The c ity of Okazaki. incorporated in 19 1 6. is loca ted 30
kilometers sou th west of Nagoya. the four th largest city in
J apa n . A high -speed urban train connects th e two cities.
Okazaki. with a population of 275.000. is a typicalmedium-size city in J apan and offe rs the conven1ence ofurban lif e while avoiding th e d isadvantages of a larg e city
Okazaki is th e commerc ial as wel l as cu ltural ce nt er o f the
Mikawa (Three R1ver) district with its rich historical heritage.
lyeyas u Tokugawa. the first Tokugawa Shogun. was born herein 1 542 and built a castle here Th e orig in al parapets andmoats and the rebuilt castle sti ll dominate th e city as they did
500 yea rs ago. When he estab lished the Shogunate in Edo(the former name of Tokyo) in 1 603. lyeyasu t ook a large
contingent of Mikawa Bushi (Mikawa Sam urai o r pro f essional
warriors) with him. Those Mikawa Bushi formed the nucleus
of lyeyasu's new adm ini stration.
Within a radius of 10 kil omete rs from the c ity center are
located Mitsubishi Motor's Okazaki Plant. Toyota Motor's
main production facilities in Toyota City, and Sony's ultr-amodern Koda plant wh1ch produces video tape reco rders.

TRANSPORTATION

Nationa l Rail way's (JNR) super train (KO DAM A or ECHO) Th etrain run s every 30 min.
Fr om Toy o- ha sh i to Okazaki
Twenty fi ve minutes by the M eit etsu (Nagoya Railway) exp ress. M ei-tet su's st ation in Okazaki
is Hi gash i (or East)-Okazak i. Th e train runs every 20 to 30
min. This is th e most co nvenie nt route to come to Okazaki
from Tokyo.
From Tokyo t o Nagoya Two hrs by th e JNR's super train(HIKARI or LIGHTENING) Th e tra in runs every 30 min .
Fr o m Kyoto/Osaka t o Na goya: One t o two hrs by the JNR's
super train (HIKARI/KODAMA). Kin-tetsu (Kinki Nippon
Railway) also serves between Osaka / Nara and Nagoya.
From Nagoya to Oka zak i Th irty five minutes by the Mei-tetsu
express which run s eve ry 20 min. M ei-t etsu's st at io n in
Okazaki is Higashi (or East)-Okazaki.

BY AIR
Domestic ai rli nes serve Komaki. Nagoya. airp o rt which is 1 hr.
dr ive fr om Okazaki.

WEATEHRIn Okazaki. temperature goes up to 30 degree cent igrade inth e summ er and down to a few degrees above the fr eezi ng
point in th e wi nter. May to June is th e rain y seaso n and the
spr ing (Mar c h to May) and fa ll (September to Novemb er) arem ost pleasant.

BY TRAIN
From Tokyo to Toyo - has hi

Two and half hr s by th e J apa n

17THE OKAZAKI CASTLE.
THE HOME OF THE FIRSTTOKUGAWA SHOGUN. IYEYASU .

18

DIRECTOR GENERALTOKINDO S. OKADA. B. Sci . & D. Sc1 . (zool og y.

Ky o to Un1v).
Research Assoc1ate. Dept. of Zoology. Kyoto Un1v. ( 1954-59). M acaul ley
Fell ow. Un1v. Ed111burgh (1957 - 59). Lecturer. D ept. of Zoology. Ky o to Un1 v.
( 1960-61 ). Assoc1ate Professor. Dept. of Zoology. Kyoto U n1v. ( 196 2 - 66).
Carnegie Fell ow. D ept. of Embryology. Carneg1e l nst1tut1 o n of W ash1ngton(1964 -65). Pr o fessor. D ept. of B1 ophys1 cs. Kyot o U n1v. ( 1967 ).
D1recto r General. NIBB (1984- ).

PROFESSORS
GORO EGUCHI. D1v1 S10n of M orph ogenesiS. B. Sc1. & D . Scr (b1ology.
Nagoya Un1v ). Research Assoc1ate. Department of 81ology. Nag oya Un1v.
(1959 - 68). Assoc1ate Pro fes sor. Department o f B1ophys 1CS. Kyoto U n1v.
( 1968-76). Professor. l ns t1tut e fo r Molecul ar B1 ology. Nagoya Un1v.
(1976 - 84). Pro fessor. NIBB (1983- )YOSHIH IKO FUJITA . DIVISIOn of B1oen erget1cs. B.LA (l1beral art s.
Un1 v Tokyo). M . Sc. (b1ol ogy. Un1v. Tok yo). D . Sc. (b,ochem,stry. Un1v. Tokyo).
Research Assoc1ate. lnst. Appl . M1crob1ol .. Un1 v . Tokyo (1957 - 67).
Postdoctral Fellow. Un1v. Texas ( 1962 -6 4). Research Ass oc 1a te. Un1v. Texas(1965). Assoc1ate Prof esso r. Ocean Res . ln st.. U n1v. Tok yo (1967 - 77).
Pr ofessor. Ocean Res . l nst.. Un1v. Tokyo (1977-1982). Professor. NIBB
(1979 ). Act111 g D1rect o r. NIBB (F eb - Sep t. . 1984) .
MASAKI FURUYA. D1v1sion of B1olog,cal Reg ulat1on . B. Sc1. & D. Sc1.
(botany. Un1v . Tokyo). Ph . D. (plant phys1ology. Yal e Un1 v.). Research
Assoc1ate. Yale Un1 v. (1962). Research Fellow. Harvard Un1 v . ( 1962 - 63).
A ss1stan t Plant Phys1olo g 1st. Br oo khaven Na t1 o nal Lab. ( 19 63 - 65 ).
A ssoc 1ate Pr o fessor. Nagoya Un1v . ( 1965- 68). Profes so r. Un1v. Tokyo( 1969 ). Adjunct Pr o fessor. NIBB ( 1980).
YUKIO HIRAMOTO . D1v1S10n o f Cell Pr ol,feratlon. B. Sc1. & D. Sci .
(zoo logy. Un1v . Tokyo). Research Assoc1 ate. Zoolo g 1ca l In stitut e. Un1 v . Tokyo(1952-54). Lecturer. Zoolog1cal lnst 1tute. Un1v. Tokyo (1954-56).
Assoc1ate Professor. M1 sak1 Manne B1olog 1cal Sta t1 on. Un1v . Tokyo (19567 1 ). Professor. To kyo ln st1tut e of Technology ( 1971- ). Ad1unct Professor.
).
NIBB (1981 -TSUNEYOSHIKUROIWA. D1 v1s10 n of Cell Mechanism. B. Scr(b 1o logy. Tokyo M etr opo l1t a n Un1v ). M . SCI & D. Sci . (b o tany. Un1v. Tokyo).
Staff M em ber. Tokyo M etr opo lit an Isotope Research Center (1970-72).
Assoc1ate Professor. Ok ayama Un1v. (1972 - 77). Assoc1ate Preoiessor. NIBB
(1977 - 1982). Professor. NIBB ( 1983- ).

KEIICHI MIMURA. D1v1S1 0 n o f Behaviour and NeurobiOlogy. B. Sc1.
(psychology, Tokyo Bunnka (Literature and Scienc e ) Un1v.). M. D.
(physiology. Nagasaki Un1 v). Research As soc 1ate. No rth western Univ.
( 1 9 59 - 60). Research Fellow. Depa rtment o f Neurob1ology. Research
School of B1olog1cal Sc1ences. Austral1an Nat1onal Un1v. (1973-75).
Professor. Faculty of L1 beral Arts. Nagasak i U n1v. (1970- ). Adjunct
Professor. NIBB (1979- ).
KEN -ICHI NAKA. D1v1S1on of Sensory Pr ocess mg. B. Scr. M . Scr & Ph.
D . (b1ology. Kyushu Un1v.). V1s1t1n g Fellow. NIH ( 1960- 62). Resea rch
Zoo lo g1st. UCLA (1962 - 63). Research Fellow. Un1v. Cambr1dge (196364 ). Staff Member. Sh1 onog1 Research Lab. ( 1 964- 6 7). Research Assoc1ate
and Sen1o r Research Assoc1ate. Cal1f. In st. Tec h. ( 1 968 -7 7). Professor.
Departments of Phys1ology and B1 ophys1cs and Ophthalmology. UTMB
(1976 - 79). Pr o fesso r. NIBB (1979 )YASUTOMI NISHIZUKA. D1V1 S10 n of Cellular Commun1cat1on. M . D.
(Ky o to Un1v. Scho o l o f M ed 1cme). Ph . D. (b1 oc hem 1stry. Ky o to Un 1v. Graduate
Course). Research Assoc1ate. Kyoto Un 1v. School of Med1C1ne ( 1962-64).
Assoc1ate Pr o fessor. Kyoto Un1v . School of M ed 1c1ne. Dep t. of Med. Chern .
( 1964 - 68). Gues t lnves t1 ga tor . Rockefe ll ar Un1v. ( 1964 -6 5). Professor.
Kobe Un1v. School of M ed 1c 1ne. Dep t. of B1 oc hem. ( 1 969 ). Adjunct
Profess or. NIBB ( 1980- ).
YOSHIO OKADA. D1v1s,on o f Ce ll Fus1on. M. D. & Ph . D . (b1ology.
Osaka Un1v. M ed Sch oo l) . Research Assoc1ate of Researc h Institute forM1crob1al D1sease. Osaka Un1v ( 1953 - 62). Assoc1ate Prof ess or of the lnst.
(1962 - 72). V1s1 t1 ng Researcher at D ep t. o f Emb ry o lo gy. Un1 v. Ch1cago(1966 - 67). Professor of Osaka Un1v. (1972- ). Adjunct Professor. NIBB
(1978 ).

19

YOSHIAKI SUZUKI . D1v1S10n of Cell D1fferent1at1on. B. Sc1 & D . Sc1 .
(pharmaceut. sc1 .. Un1 v. Tokyo). St a ff M embe r. NIH o f Japan (1959 - 71 ).
Postdoctoral Fellow. Dept. of Emb ryology. Carneg1e InStitUti on of Wash1ngton( 1968-7 1 ). Sen1or Staff M ember. NIH of Japan ( 19 7 1 -73). Staff Member.
Dept of Embryolo gy. Carneg1e In sti tutiOn o f W as h1ngton ( 1973-7 8).
Professor. NIBB (1978 )ASSOCIATE PROFESSORS
KOHJI HASUNUMA. Rad10 1so tope Facli1ty. B. SCI (b1o logy. Un1 v.
Tokyo). M. Sc1 . & D . Sc1. (botany. Un1v. Tokyo). Research Assoc1ate. Un1v.
Tokyo (1971-79). Assoc1ate Professor. NIBB (197 9- ).
SUSUMU HIROSE. DIVISIOn o f Cell D1ff e re nt1 a t1on. B. Sc1 (b1ology.
Tokyo Kyo1ku Un1v ). M . Sc1. (b1ochem1stry. Un1 v Toky o ). D. Sc1 (b1ophys1cs.
Un1 v. Tokyo). Resea rch Fellow. U ni v. Tokyo ( 1 9 71 -73 ). Research Ass oc 1ate.
Nag oya Un1v . (1973-79). Assoc1ate Professor. NIBB (1979- ).

YOSHITAKA NAGAHAMA. DI VISIOn o f Reproductive B1ology. B.
Sc1. M . Sc1. & D . F1sh . (b1 o logy. Hokka1do Un1v ). Postdoctora l Fell ow. Un1v. of
Cal1forn1a. Berkeley ( 1 9 72-7 4 ). Un1v. of Br1t1sh CokJmb1a ( 1 9 7 4-7 6 ).
Resea rch Assoc1ate. Un1v . of British Columb 1a (1976 - 77). Assoc1ate
Research Endocrlllo logiSl. Un1 v. of Cal1fon11a. Be rkeley (1977). Assoc1ate
Professor. NIBB (1977 ).
TOSHIYUKI NAGATA. DI VISIO n of Cel l M echa n1sm. B. Sc1 . (b1ology.
Un1v. Tokyo ). M . Sc1 . & D . Sc1 (botany. Un1v. Tokyo). Research Assoc1a te.
Un1v. Tokyo (1973-1979). Research Assoc1ate. Nagoya U111v. (1980 1983). Assoc1ate Professor. NIBB (1983- ).

HIDEAKI NAKASHIMA. D1v1S1on of Chronob1ology. B. Sc1 . & M . Sc1 .
(botany. H1rosh1ma Un1v ). D . Sc1. (botany. Nagoya Un1v.). Research
Associate .. Nagoya Un1 v. (1969-80). Res earc h Fellow (Postdoc toral). Un1v.
o f Calliorn1a at Santa Cruz (1979 - 80). Assoc1ate Professor. NIBB ( 19801

TATEO SHIMOZAWA. D1v1S1 0 n o f Behav1our and N eurob1ology. B.

(b1ochem1stry. Un1v . Tokyo). Research Assoc1ate. Fac . S1c .. Kyushu Un1v.
(1975-82). Assoc1at e Professor. NIBB (1982- ).

Sc1 & M . Sc1 (electroniCS. Hokka1d o Un1v .). D . Sc1 (b1ology. Hokka1do Un1v .) .
Research Assoc1ate. W ash111g ton Un1v. (1972 -7 3). Research Fellow. C a l.
Jnst Tech . (1973-74). Assoc1ate Professor . Zoolog,callnstnute. Hokka 1do
Un1v . (1968 ). AdJunct Assoc1ate Pr o fesso r. NIBB ( 1980).

ISSEI MABUCHI . D1v1S10n of Cell Prol1ferat10n. B. Sc1. & D . Sc1.
(b1ochem1stry and b1ophys1cS. Un1v. Tokyo ). Resea rch Assoc1ate. Dep a rtm en tof B1ology. College of General Educat1on. Un1v . Tokyo ( 1 9 7 3-1 981 ).
Assoc1ate Pr o fessor . D epa rtm ent o f B1olo~y. College o f Gen era l Educat1on
U n1v . Tokyo (1 981 ).AdJunct Assoc1ate Pr o fessor. NIBB ( 1982 I

YOSHIMI TAKAI . D1 v is1on of Cellul ar Commun1cat10n. M . D . & Ph . D .
(blochem,stry. Kobe Un1v. School o f M ed 1C1ne). Resea rc h Assoc1at e. Kobe
Un1v. Schoo l of med1c1ne. Dept. of B1ochem . ( 1 97 5-8 1 ). Assoc 1ate
Professor. Kobe Un1v. School of M ed1c1ne. D ep t. of B1o c h em (1981 ).
AdJunct Assoc1ate Prof esso r. NIBB (1981 ).

KATSUSHI MANABE. D1V1S1on o f B1olog,cal Regul at 1on . B. Sc1 .
(b1ology. Tohoku Un1v.). M . Sc1 & D . Sc1. (b1ology, Nagoya Un1v.).
Postdoctoral Fe llow. Na goya Un1 v. (1972-73. 1974 -75). M1 ch 1g an State
Un1v. (1975 -7 6). U n1v. lll lnOI (1976-77). Assoc1at e Professor. Yokoh ama
City Un1v. (1977 ). AdJunc t Assoc1ate Professor. N IBB (1984 ).

MASARU YAMAIZUMI . D1v1S10n o f Cell Fus1on. M . D. (med1c1ne.
Kyoto Un1v ). Ph . D . (v1rology. Osaka Un1v .). Research Assoc1ate. Research
Jn s t1tut e for M1crob1al D1seases. Osaka Un1 v. (1975-82). Research Fellow.
D epa rtment of B1ology. Yale Un1v. (1980). Research Assoc1ate. Jnst1tute for
M olecul ar and Cellular Bi o logy. Osaka Un1v . (Apni - July. 1982). Asso c 1a te
Professor. Institut e for Molecular an d Cellular B1ology. Osaka Un1v. (July.
1983- ). Asso c1a te Prof esso r NIBB (1983- ).

SHIGERU ITOH . D1 v 1S10 n o f B1oenerget1cs . B. Sc .. M . Sc .. D . Sc.

YASUHIRO MIYOSHI. D1v1S10n of B1olog,cal Regul a t1on. B. Sc1(phySICS. Sh1zuoka Un1v.). M. Sc1 & D. Sc1 (appli ed phys1cs. Waseda Un1v .).

20

Research Assoc1ate. Gunma Un1v. (1968 - 69). Assoc1ate Profes sor. Un1v.
T o kyo (1969 ). Adjun c t Asso1cate Pr o fessor. NIBB (1978-Mar . 1984) .

SHOZO YASUI. DIVISIOn of Sensory Processmg. B. Eng . (aeronautiCS.
Univ. Tokyo). M. Sc1. & Ph. D. (bioengmeermg. Mass . ln st. Tech). Staff
Tosh1ba Res. Lab . ( 1 9 70-71 ). Reseach Fellow. Cali f. In st. Tech. ( 19 7 2-7 4 ).
Assistant Professo r. UTMB (1976 -79). Assoc1ate Pr ofessor. NIBB (1979)(chemistry, Un1 v. Tokyo). M . Sc1. & D. Sc1. (zoology, Un1 v. Tokyo). Research
AssOCiate. NIBB (1978- ).

RYUJI KODAMA. Div1sion of Morphog enesis. B. Sc1 . (biophysics andb1ochem 1stry. Un1v. Tokyo). M. Sc1 & D . Sc1. (molecular biology. Nagoya
Un1v.). Research Assoc1ate. NIBB (1983- ).
KENJI KOHNO, DIVISion of Cell Fu s1on. B. Sc1 .. M . Sc1 . & D. Sc1 .
(microbiology, Univ. Tokyo). Resea rch Associate. NIBB (1980- ).
TAKAO KONDO. Div1sion of Chronob1ology, B. Sci. M. Sci. & D. Sci.

RESEARCH ASSOCIATESKIYOKAZU AGATA. D1vi sion of Morphogenesis. B. Sc1 . & M. Sc1 .
(b1ophys1cs. Kyo to Un1 v.). Research Assoc1ate. NIBB ( 1983- ).
YOSHIOHAMADA. T1ssue

and Cell Cu lt ure Laboratory B. Sc1(biology. Osaka Univ .). M. Sc1. & D. Sc1. (b1ophys1CS. Kyoto Un1v.). Research
Associat e. NIBB ( 1 9 7 9- ).

(biology. Nagoya Un1v.). Research Assoc1ate. NIBB ( 1978-).

MAMORU MIMURO. D1 vis1on of Bioenergetics B Sci .. M. Sci . & D.
Sc1. (biology. Un1 v. Tokyo). Postdoctoral Fellow. Ocean Res. lnst .. Un1 v. Tokyo(1978-80). Research Associate. NIBB (1980 ).
KAZUO OGAWA. D1v1S10n of Cell Mechanism. B. Sc1 .. M. Sc1. & D. Sc1(biology. Tokyo Metropolitan Ut11 v.). Jun1or Research. Un1v. Hawa11 ( 1975).
Research Fellow. Cal1f . lnst. Tech. ( 1976). Research Assoc1ate. NIBB (1979 )EIKI HIDA. D1vision of Sensory Processing. B. Sc1. (mathematiCS. Nagoya
Un1v.), M . Sc1. (b iophyS ICal engmeering. Osaka Un1v.). Research Assoc 1ate.
NIBB (1979- ).

KAORI OHKI. DI VISIOn of B1 oenerget1CS. B. Agr. (agriculture. Kyoto
Un1v .). M . Sc .. D. Sc. (b1ology. Kyoto Un1 v.), Techn1cal Staff. Ocean Res . ln st..
Un1v. Tokyo (1975-82). Research Assoc1ate. NIBB (1982- ).

KEISUKE HIRASAWA. DI VISIOn of Cellular Communication. B. A.
(agricultural chemist ry. Hiro sak i University). M . Sc. (molecular sciences.
Warw1ck Universi ty). Ph . D . (biochemistry, Cambr1dge Univers ity). Research
Associate. NIBB (1983-Jun 1984)

HIROKO SAKAl. DivisiOn of Sensory Processmg. B. L. A. & M. A .
(psychology. Int. Chri stia n Univ.). D. Sci. (zoology. Kyoto Un1v ). Resea rch
Associate. NIBB (1979 )MASAHIRO ISHIURA. D1 visionof Cell Fus1on. B. Sc1 (b1ology.
Kanazawa Univ.). M. Sci . & D. Sc1. (bio logy, Osaka Univ.). ResearchAssoc1ateof Research In sti tute for M1 c robial D1seases. Osaka Uni v. ( 1977-79).
Resea rch Associate. NIBB (1979- ).

SIGEYUKI KAWANO. Di v1sion of Cell Mechanisms. B. Sc1. & M. Sc1(biology. Okayama Un1 v.) D . Sc1. (biology, Tokyo Metropol1tan Un1 v.).
Technical Staff. NIBB (1978 - 1983). Research Assoc1ate. (1983- ).
TAKEO

KISHIMOTO. D1v1S10n

of

Reproduct ive

Bi o logy.

B. Sc1.

HIROKO SHIRAI. DI VISIOn of Reproductive B1ology. B. Sci. (biology.
Yokohama Mun1c1pal Uni v.). D . Sc1. (biology, Uni v. Tokyo). Techn1c al Staff.
Univ. Toky o (1966-77). Resea rch Associate. NIBB (1977- ).
TEIICHI TANIMURA.

Div1sion of Behav1our and Neurobiology, B. Sci.
(food chem ist ry. Tohoku Univ ). M . Sc1. & D. Sci. (b iOlogy, Tohoku Uni v ).
Research Assoc1ate. NIBB (1980- ).

SATORU TOKUTOMI. Di viSIOn of BIOlogical Regu lati on. B. Sc1. M .
Sci. & D. Sci. (biophysics. Kyoto U niv ). Resea rch Fellow. Kyoto U niv. ( 1 9 7 880). Research Associate, NIBB (1980 ).

21

MASAAKI TSUDA Div1s1 o n o f Cell Dlfferent1at10n. B. Scr (biOchem istry. U n1v . T okyo). M . Sc1 . & D . Sc1 (pharmaceutical SCI .. Un1 v. Tokyo).
Postdoctoral Fe ll ow. Carneg1e ln st. (1978-79). Research Assoc 1a te. NIBB
(1979 )

30. 1984)

YOSHIHIDE TSUJIMOTO . DI VISion of Cell D1fferen uat1 on. B. Sc r . M.

FREDERICK W. GOETZ. DI VISion of Reproduct1ve B1olo gy. B. Sc1.

Scr & D. Sc1. (b1ology, Osaka Un1v .). Pos tdo c to ral Fellow. Carneg1e lnst.
(1977-79). Research Assoc1ate. NIBB (1979 - )(b1o logy. Colga te Un1v ). M Sc1 & Ph D . (b1ology. Un1 v. Wyom 1ng). Assoc1a te
Professor. U 111v. Notre Dame. NIBB (Jan . 11-Jun. 30. 1 984)

MASAKATSU WATANABE. Lar ge-Scale Spectrograph Laboratory.
B. Sci .. M . Scr & D. Sc1. (b 1ology. Un1v. T okyo). Research Fellow. Un 1v. Tokyo(1974 -78 ). Research Assoc1ate. NIBB (1978 )PETER J. LUMSDEN. D1v1S10n o f B1olog1cal Regu lat1on. B. Scr(appl1ed b1ology. Un1v . Bath). Ph . D. (Un1v. Sussex). NIBB (Feb 1 984- ).

KOTARO YAMAMOTO . D1v1S10n of B1olog1cal Regu lation. B. Sc1. M .
Sci . & D . Sc1. (botany. Un1 v. Tokyo). Predoctoral Fel low. Sm1thson1an
lnst1tut 10n (1977 -79). Res ea rc h Assoc1ate. NIBB (1980- ).

PHILIPPE BULET. D1V1S 10n o f Reproduct 1ve B1o logy. B. Sc1. M . Sc1 .. &Ph. D. (b1ology. Lil le Un1v.). Postdoctoral Fellow. NIBB (Feb . 1 1. 1984- ).

RESEARCH FELLOWSYASUAKI YOSHIMOTO . D1v1S10n of Cell Prol1ferat10n. B . Scr. M . Scr& D . Sc1. (b1ology. Osaka. Un1v .). Research Assoc,ate. NIBB (1977 -).

The Institute Research Fellows
KATSUMI MATSUURA. D1v1S10n of B1oenerget1cs. B. Scr (photobio logy. Tokyo M et ropolit an Un1vers1ty), M. Sc1 .. D . Sc1. (photobiology,
Kyushu Un1vers1ty). L ecturer. NIBB (April 1. 1983- ).

FOREIGN VISITINGSCIENTISTS
Sponsored by the Mombusho
RICHARD D . COPENHAGEN, D1v1S10n of Sensory P r ocess~ng. B.
Sci. (electnc eng ine ering, Stanford Un1vers1ty). M. Sc1. Ph . D . (computersc ience. U n1vers1ty Californ,a). Assoc1ate Professor. Un1 vers1ty of Callforn1a.
San Franc1sco. NIBB (Ap ril 15-Se ptember 14. 1983 and December 1-28
1 983)'.

Sponsored by JSPSCHARLES W. WALKER. D 1v1S 10 n of Reproduc ti ve B1o logy. B. Sc1 ..
(zoology, M 1ami Un,verslty). M . Sc1 .. Ph. D. (zoology. Cor n ell Un1vers1ty),
Associa te Pro fesso r. Un1vers1ty of New Hampsh 1re. NIB B (July 1. 1983-Ap r

22

MASATOSHI MITA. DIVISI On of ReproduCtive B1ology. B. Sc 1.. M . Scr.
D Sc1 (b1ology. Waseda Un,verslty). Lecturer. NIBB (April 1. 19 83- ).

JSPS Research Fellows
HIROSHI HOSOKAWA. DIVISIOn of Sensory Process~ng. B. Scr. M .
Sc1 .. D. Scr (b1oeng~neer~ng. Osaka Un, vers ,ty), Postdoctra l Fe llow. N IBB(Apr il 1. 1983 ).
SHIN-ICHI HISANAGA D IVISIOn ol Cell Prol1ferat1on. B . Scr. M . Sc 1..
D. Sc1. (zoo logy. Un1vers1ty of Tokyo). Postdoctral Fell ow. NIBB (April 1.
1983- )

Research Support GroupTECHNICAL DEPARTMENTSTAFF

SATOKO ADACHI . Department of Developmental B1ology. Bache lor.
(home

OfficeHACHIRO HONDA. (An1o Agr1cultural and Forestry H1gh School).
Techn1cal Staff. Nagoya Un1v. (1953-78). Manager. T echn1cal Department.
NIBB(1978 I

Common Facility Group

sc1enceofTechn1cal Staff. NIBB (1981-

econom 1cs).

sc1ence. Fuku1 Un1v ). Techn1cal Staff. NIBB ( 1980-).

KAZUHIKO FURUKAWA . Rad1o sotope Facil1ty.
Toho Un1v.). Techn1cal Staff. NIBB (1979 ).

B. Sc1. (b 1ology.

HIROYUKI HATTORI . Centerl1v1ng.

H1r osh 1ma

Women's

SHINJI ADACHI. Department of Developmenta l B1ology.
(b1ology. Hokka1do Un1v ). Techn1cal Staff. NIBB (1980- ).

Co ll ege ).

B

F1sh.

YOHKO FUJIMURA. Department of Regulat 1on B1ology. B. Sc1.
(b1ology. Tokyo M etropol itan Un1v ). Techn1cal Staff. NIBB (1980- ).
SOH HIDAKA.

YUICHIRO ANDO. Laboratory Computer Facility. B. Sc1 (lllformatiOil

1n

Department of Regulation B1ology. B. Sc1 . (b1ology.

Nagoya Un1v). Techn1cal Staff. NIBB (1981-

I

HISAYO KONDO . Department of Developmental B1ology. B. Sc1.
(b1ology. Japan Women's Un1v.). Techn1cal Staff. Tokyo l ns t1t u te ofTechnology (1975-76). Techn1cal Staff. Te1kyo Un1 v. School of Med1c1ne(1976-78). Techn1cal Staff. NIBB (1978- ).

for Analyt1cal Instruments. B. Sc 1.
Nagoya Un1v ). Techn1cal ofl1cer. Nagoya Un1v (1965-79).
Ch1ef Techn1 cal Staff. NIBB (1979- ).

AKIO MURAKAMI . Department of Cell B1ology. B. Sc1. (b1o logy.
Waseda Un1v ). Resea rch Fe ll ow. Un1v Tokyo I 1978-81). Techn1cal Staff.

HIROKO KAJIURA . Center for Analyt1ca l In s truments.
(chemistry. Nagoya Un1v.l. Techn1cal Staff. N IBB I 1980- I

SOICHI NAKAMURA. Department of Cell B1ology. B Sc1. & M . Sc1.
(b1ology. Tokyo l nst. Tech). Techn1cal Staff. NIBB 11979- ).

(agr~culture.

B.

Sc1.

NIBB (1981-I

HISASHI KOJIMA. Center for Analyt1cal l nstruments. B. Sc1. (1ndustr1alchem1s tr y. Nagoya Institute of T£2chnology). Techn1cal Staff. N IBB I 1982- )MASAHIRO NASU. Department of Regulat1on
Techn1cal H1gh School). Techn1cal Staff. NIBB (1982-

MAMORU KUBOTA. Large-Scale Spectrograph Laboratory. (rad1ocommun1cat10il. M1ya F1shery H1gh School). Techn1cal Staff. NIBB (1980- ).

SHIGEHARU TAKIYA. Departm en t of Developmental81ology. B Sc1..

B1o logy.
).

!Me1nan& M . Sc1. (b1ology. Hokka1do Un1v ). JSPS Research Fellow. Hokka1d o Un1v.
Techn1cal Staff. NIBB (1983-I

CHIEKO NANBA. Exper1mental Farm. (Agriculture Sh1ga Prefecture
Jun1or Col). Te chn1ca l Staff. NIBB (1984-I

TOSHIKI OHKAWA. Glassware Cleanlllg Faci11ty. iShlm1zu-m1nam1
H1 gh School). Techn1cal Staff. NIBB (1984 I
YUKIE

SHINOHARA. RadiOISOtope Facil1ty.
Kyu shu Un1v.). T ec hn1cal Staff. NIBB (1981- I

B

Sc1

GRADUATE STUDENTS(agr~culture.

HIROSHI ABE.

D1v1S10n of B1olog1cal Regulat1on. B . Sc1.. (b1ology. Tokyo

23

Metropolitan Un1v). Graduate Student. NIBB (Apr. 1. 1983-).

TATSUO ARITA.

D1v1sion of MorphogeneSIS. B. Med. (med1c1ne.
Kumamoto Un1v ). Graduate Student. N IBB (Apr 20. 1984- ).

KOJI KONOMI. DIVI SIOn of B1olog1cal Reg ulation. B. Sc1. & M. Sci.
(botany. Univ . Tokyo). Graduate Student. NIBB (Sep. 1. 1980-Mar. 3 1.
1982: Apr. 1. 1984- I
SHIN -ICHI MIYAMURA. D1v1S10n of Cell M echan1sms. B. Sc1 . & M .

YASUNORI BAN. DIVISion of Cell D1fferen t1at1 on. B. Sc1 (b1ology.
Sh 1zuoka Un1 v.). M. Sc1. (agncultural chem1st ry. Nagoya Un1 v.). Graduate
Student. NIBB (Apr 1. 1983- I

CHEN HAIWEN. DIVISIOn of Sensory Process~ng. B. Sc1. & M. Sc1(computer sc1ence. Nagoya lnst. Technology). Graduate Student. NIBB (Sep .
3. 1984).
SHIN -ICH HANDA. DIVISIOn of Cell D1fferent1at1on. B. Med . (med1c1ne.
Ak1ta Un1v ). Graduate Stu dent. NIBB (Apr. 1. 1983-Mar. 31. 1984)

Sc1 (b1ology. Nagoya Un1v.). Graduate Student. NIBB (Apr. 1. 1984-).

MAKOTO MOCHII. DIVISIOn of Morph ogeneS IS. B. SCI (b1ology.
Nagoya Un1v ). Graduate Student. NIBB (Sep . 12 . 1983- ).
AKIRA NAGATANI. D1v1S10n of B1olo g1cal RegulatiOn. B. Sc1. & M . Sc1(botany. Un1v. Tokyo). Graduate Studen t. NIBB (Feb. 1. 1983-Jan. 31.
1984)
TAKASHI OBARA. D,v,s1on of Cell D1fferent1at1on. B. Sci . & M . Sc1(b1ology. Sa1tama Un1v.). Graduate Student. NIBB (Apr . 1. 1984-).

NAOHIRO HASHIMOTO. D1v1S10n of Reproduct1ve B1ology. B . Sc1 &M . Sc1. (zoology. Un1v. Tokyo). Graduate Student NIBB (Apr 1. 1983-).

YASUYUKI OKABE. D1v1S10n of B1oenerget1CS. B . Sc1. (b1ology. Toho
Un1v .). Graduate Student. NIBB (Apr . 1. 1984- ).

YUZOU KADOKAWA. D1V1S1on of Morphogenes1s. B. Sc1. (zoology.
Kyoto Un1 v.). M. Sc1 (molecular b1ology. Nagoya Un1v.). Graduate Student.
NIBB (Jul 1. 1983- ).

YUICHI KADOYA. D1v1S1on of Morphogenes1s. B . Sc1. (b1o logy. Nagoya
Un1 v.). M. Sc1 (molecular biology. Nagoya Univ.). Graduate Student. NIBB
(Jul. 1. 1983- ).

HIKARU SAJI. D1v1S10n of Biological Regulat1on. B. Sc1 & M . Sc1(b1ology of agncultu re and forestry. Kyoto Un1v.). Graduate Student. NIBB
(Apr. 16. 1980- ).
NORIYOSHI SAKAl. D1v1S10n of Reproductive B1ology. B. Sc1.
(b1ology. A1ch1 Un1v . Education). Graduate Student. NIBB (Jun . 8. 1984- ).

AKIRA KANAMORI. D1 vis10n of Reproduct1ve Biology. B. Sc1 . & M .
Sc1. (zoology. Un1v. Tokyo). Graduate Student. NIBB (Apr. 1. 1984)

TAKASHI TAKEUCHI.

YOKO KARASAWA. D1v1S10n of Morphogenesis. B. Sc1 . (biology.
Nagoya Un1v.). M . Sci. (molecular b1ology. Nagoya Un 1v.). Graduate Student.
NIBB (Jul 1. 1983 -Mar. 31. 1984)

MIKAKO TSUKADA. DIVISIOn of Behav1our and Neurobiology. B. SCI.
& M. Sc1 (b1ology. Tohoku Un1v ). Graduate Student. NIBB (Apr. 1. 1982- I

of Sensory Process~ng. B. Sc1.
(sc 1ence. Wa se da Un1v.). M. Sc1 . (b1ology. Joch1 Un1v ). Graduate Student.
NIBB (Apr 1. 1983-Mar. 31. 1984)-MASASHIKAWASAKI. DIVISIOn

KEN -ICHI KIMURA. DIVISIOn of Behav1our and Neurobiology. B . Sc1 &M . Sc1. (b1ology. Hokka1d o Un1v ). Graduate Student. NIBB (Apr . 1. 1983- )D1v1S10n of M orphogeneS IS. B. Sci. (b1ology.
Nagoya Un1 v.). Graduate Student. NIBB (Sep 1 2. 1983- )ETSUO YOKOTA. D1v1S10n of Cel l Prol1ferat,on. B. Sc1. (b 1o lo gy. Ch1ba
Un1v ). Graduate Student. NIBB (May 21. 1984- ).
KIYOKO YOKOYAMA. D1vis1on of Sensory Process1ng. B. Sci. & M.
Sc1. (computer sc1ence. Nagoya l nst. Technology). Graduate Student. NIBB
(Apr. 1. 1 982-Mar. 31. 1984)MICHIYASU YOSHIKUN'I.

D1v1S10n of Rep roduct1ve B1 o lo gy. B Sc1& M . Sc1. (b1ology. Sh1zuoka Un1v.). Graduate Student. NIBB (Apr . 1. 1984- ).

24

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