This English translation is provided for the information purpose only.

Hokkaido University Graduate School of Medicine

Application Guidelines 2024
Doctoral (PhD) Program in Medicine
Basic Medicine Course
Social Medicine Course
Special Selection for International Applicants（For enrollment October 2024）

Hokkaido University Graduate School of Medicine

Outline of Doctoral (PhD) Program in Medicine(Excerpted version)
1. Educational Philosophies, Educational Goals, Expectations of Students, Basic Policy for Entrant
Selection
Under the basic philosophies of Hokkaido University, “Frontier Spirit”, “Global Perspectives”, “All-round
Education” and “Practical Learning” and the educational philosophies of the Graduate School of Medicine“to lead the world with cutting-edge research in medical science” and “to equip the next generation of
medical researchers and medical professionals with a strong sense of ethics and a well-rounded character tocontribute to the health and welfare of humanity”, the Graduate School of Medicine sets its educational goal
to nurture individuals who possess high ethical standards, highly specialized knowledge, and research andteaching capabilities regarding medicine and life science , as well as individuals who possess the deep insight
to meet the diverse, wide range of health and safety requirements from local and international community.
The Graduate School of Medicine expects “① students who are willing to be engaged in research tailored
to clarify life phenomena, to overcome diseases, and to improve human health standards” and “② students
who have intellectual curiosity, show the ability to analyze things logically, persevere as a team, and aspire
to work as international leaders in each medical field.” and “③ Students who have fundamental
reading comprehension in foreign language (English) and writing skills before enrollment ”
Admission shall be determined individually based on the comprehensive evaluation of Oralexamination, and application documents submitted.
・ The evaluation methods and the evaluation weight and the relationship between
Expectations of Students and the evaluation methods
Matters Matters Matters
Entrance exam
Evaluation Evaluation
related related relatedclassification
methodweight
to ①
to ②
to ③
Oral
◎
✔
✔
✔
Special
Selectionfor examination
International
Application○✔
✔
Applicants
Documents
The mark ◎ indicates elements that are particularly important
The mark ○ indicates elements that are important✔ is the Expectations of Students evaluated in the each evaluation methods

2. Expected Competencies, Diploma Policy
Based on the “Educational Goals” of the Graduate School of Medicine, in the Doctoral Program, we aim tonurture highly qualified individuals who play active roles as (i) international researchers in domestic andinternational universities or research institutions, (ii) clinicians and medical scientists in medical institutions
who excel in both clinical techniques and research competence, or (iii) highly specialized professionals
engaged in health services administration and public health in administrative organizations, companies andso on.
In order to develop such human resources, we grant Doctor of Philosophy to those who have attained thecompetencies to continuously contribute to the development of basic medicine research through properly
understanding the backgrounds or circumstances of medical research, making plans for research theme which
are academically and internationally significant or hypotheses which should be validated, analyzing theobtained results through verification of the validity and preparing another theme or hypotheses.

3. Course Introduction
In order to nurture individuals who attain “Expected Competencies”, we offer interdisciplinary education
beyond the boundaries of existing academic disciplines, aiming at the acquisition of basic knowledge andtechnology of mutually related fields. In addition, to nurture talented individuals responding to the diversified１social needs, we introduce three types of coursework to study systematically through multiple subjects.
Students choose the course that suits best to their purpose.
At Special Selection for International Applicants, only applications for the following courses will be
accepted.
【Basic Medicine Course】
This course aims to train researchers and educators in medical and life science field. Students acquire broad
expertise required to become independent researchers, learn various research approaches including
techniques for designing experiments, and develop their research capabilities. They are also expected toacquire the competence and skills to apply and utilize their expertise to medical and life science fields withinterdisciplinary approach.
【Social Medicine Course】
This course aims to train professionals who undertake the task of improvement of health and safety at theregional and international levels. Students start by learning research methods in social sciences including
research ethics, basic and applied statistics, medical informatics and EBM (evidence-based medicine). This
course emphasizes social medicine and preventive medicine, rather than biology and life science. Students
aim at mastering the research approaches and skills that are necessary for research in public health andpreventive medicine.

4. Course Guidance
The following 3 subjects are offered in the Doctoral (PhD) Program in Medicine.
- Required Core Subjects (Kyoutsu Koa Kamoku)- Required Subjects (Hisshu Kamoku)- Elective Subjects (Sentaku Kamoku)“Required Core Subjects” are offered to cultivate the basic quality in the education at the Graduate School of
Medicine, and are compulsory in all courses. “Required Core Subjects” include “Introduction to Medical
Research” to provide basic and systematic knowledge of medical research, and “Experimental Methods andResearch Designs” to master designing of research, basics of epidemiology and biostatics. In line with
“All-round Education”, one of educational philosophies of Hokkaido University, students learn “Medical
Ethics” which cultivates bioethics for those engaged in medicine, “Presentation Skills I & II” which develops
presentation skills and academic paper writing skills in English, and “Introduction to Translational Research”
which promotes the understanding of bridging research aimed at establishing medical technology or
pharmaceutical products in the clinical practice utilizing the results gained by basic research.
“Required Subjects” are offered according to the educational goal of each course, to acquire not only
in-depth knowledge of specialized research field but also the knowledge of outside extensive fields. In
addition, research work for doctoral thesis will be certified as credits. Furthermore, a supervisor in thedepartment will be in charge of the subject and carry out exercises for gaining the necessary ability tocomplete the dissertation.
“Elective Subjects” are offered to secure flexibility in selecting credits, and enable students to acquire a
broad view and expertise beyond the course and a framework of specialized field.
Subjects

Required Core Subjects(Kyoutsu Koa Kamoku)

Subject
Introduction to Medical ResearchExperimental Methods and Research
Designs
Medical Ethics
Scientific Presentation andCommunication
Presentation Skills I
Presentation Skills II
２

Credit111
1
12

DetailsRequired
Subjects(Hisshu
Kamoku)

Basic
Medicine
CourseSocialMedicine
CourseElective Subjects(Sentaku Kamoku)

Introduction to Translational
ResearchResearch Methods in Medical
Sciences I
Research Methods in Medical
Sciences II
Dissertation Research in Medical
Sciences
Research Methods in Social
Medicine I
Research Methods in Social
Medicine II
Dissertation Research in Social
Medicine
Principles of Medicine
Classes offered by Other Graduate
Schools
Inter-Graduate School Classes
Required Subjects from Other
Courses

1

1
1
10
1

Take one of these 3
courses and enroll all
the subjects offeredby that course.

1
10
［2］

Take 10 credits ormore including 2
credits of Principles
of Medicine offeredby belonging
department.

※ As for the subject which credit number is indicated as [number], students can takemultiple choices as far as the chosen subjects belong to different subject titles.
Completion Requirements
Students are required to be enrolled in the Graduate School of Medicine for 4 years or more to complete Doctoral
Program. (Students who achieved superior performance can complete the Doctoral Program as much as 1 year
before the end of the course term.)
Students should acquire 30 or more credits in majored fields, and pass the qualifying review and examination of
the Degree thesis (Dissertation) after receiving required research instruction from the supervisor.
How to take subjects
Students should take 8 credits from Required Core Subjects, 12 credits from Required Subjects they enroll, 10
credits or more including Principles of Medicine offered by belonging department from Elective Subjects.

３Application Guidelines 2024 to Doctoral (PhD) Program
Special Selection for International Applicants(For enrollment October 2024)
1.

Major and Number of Students Admitted
Major in Medicine (Basic Medicine Course, Social Medicine Course): a few students

2.

Qualifications of ApplicantsThose who cannot arrive in Japan during the date of examination designated by Hokkaido University
Graduate School of Medicine and those who have obtained consent from the prospective supervisor prior toapplication. Applicants must satisfy either of the following requirements:
(1)
(2)

(3)

(4)
(5)

Those who have completed or are expected to complete 18 years of formal education overseas (with asix-year final program in Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences) by 30
September, 2024.
Those who have been awarded or are expected to be awarded by 30 September, 2024 a degree
equivalent to Bachelor’s degree from overseas university or overseas educational institution bycompleting five or more years of curriculum in Medicine, Dentistry, Veterinary Medicine or
Pharmaceutical Science (including completing the said curriculum by overseas school by way of
distance education while residing in Japan or completing the curriculum at an educational institution
which is designated in the said foreign country’s education system and specifically designated by the
Minister of Education, Culture, Sports, Science and Technology).
Those who have completed 16 years of formal education overseas (with a program in Medicine,
Dentistry, Veterinary Medicine or Pharmaceutical Sciences) and subsequently have conducted research
for at least two years at a university or research institute, and are deemed by Hokkaido University
Graduate School of Medicine to have academic ability equal to or greater than university graduates in
Medicine, Dentistry, Veterinary Medicine or Pharmaceutical Sciences.
Those who have completed 16 years of formal education overseas (with a program in Medicine,
Dentistry, Veterinary Medicine or Pharmaceutical Sciences) and deemed eligible to apply by Hokkaido
University Graduate School of Medicine. (See Note.)
Those who are deemed by Hokkaido University Graduate School of Medicine under individual
qualification review to have academic ability equal to or greater than university graduates in Medicine,
Dentistry, or a six-year program in Veterinary Medicine or Pharmaceutical Sciences, and will be 24
years of age or older by 30 September, 2024. (See Note)

Note: Those who apply under Qualifications of Applicants (3) (4) or (5), must undergo Qualification Review.
Refer to “3. (6) Qualification Review” for further information.

3.

Application Procedure(1) How to Apply
Applicants have to access the web site designated by the prospective supervisor. The website will be
notified to only applicants who have obtained consent from the prospective supervisor. Applicants have tosend the original application documents listed in the following (3) Application Documents 1-8 to Student
Affairs Office by post.
(2) Application Period
Online Registration:
From 9:00 (Japan Standard Time), Monday, 10 June, 2024 to 17:00 (Japan Standard Time), Tuesday, 11June, 2024
Submission Deadline of Application Documents: 17:00 (Japan Standard Time), Tuesday, 18 June, 2024
Original application documents must arrive at Student Affairs Office by EMS or other international
express mail.
４(3) Application Documents
1

Application Form
Curriculum Vitae

2

Photo ID Card

3
4

5

6

and Access the web site and fill in your information. Print them out on A4 size
paper. (210mm x 297mm)

Access the web site, fill in your information, and print it out on A4 size paper.
Paste your photograph (full-face, applicant’s name printed on the back, 4cm x3cm) taken within 3 months before (2) Submission Deadline of Application
Documents in the space provided.
Must be issued by a university/college president or Dean, and submit a new original.
Academic Transcripts
Copy not accepted.
Download from the web site. Explain the following 3 points in English (800Statement of Purposewords.): 1. Past Research Activities, 2. The motive for the application and 3.
Future Goals.
Certificate of (expected) Must be issued by a university/college president or Dean, and submit a new original.
Graduation
or Copy not accepted. (For graduates, be sure that the certificate includes information on
your degree).
Completion*Those who graduated or will graduate from a university in China (excluding Taiwan,
Hong Kong and Macau) must submit the following documents in addition to a
Certificate of (Expected) Graduation (Completion) .
Graduates:
a. Online Verification Report of Higher Education Qualification Certificate（教育部学子注册 案表）b. Certified copies of your Graduation Diploma（）and Degree Diploma（学位）that has been authorized by a university/college
Expected Graduates :a. Online Verification Report of Student Record（教育部学籍在告）Obtain documents “a” above by requesting it at “中国高等教育学”:
http://www.chsi.com.cn/xlcx/bgys.jsp.
Also be sure that there are 15 or more days left until the expiration date of the online
verification at the time of its submission.
Copy of Passport

The page which your photo and passport number are shown on.

If English is not your first language: Copies of the following test results as
proof of English language proficiency taken within 2 years before the deadline
ProofofEnglish of application. (e.g. TOEFL-ITP, TOEFL-iBT（Home Edition acceptable）,
Language Skills
TOEIC Listening & Reading Test, IELTS Academic) For TOEIC Listening &Reading Test taken after April 2023, a printout of the PDF version of theofficial digital certificate is acceptable.
Applicants from EEA must confirm the Handling of Personal Information on
8 (If applicable)
Consent to Transfer and page 8 and submit their consent. The form will be sent by the prospective
Process Personal Data
supervisor via e-mail.
Other documents may be designated by Hokkaido University Graduate School of Medicine andrequired to submit later as needed.
7(4) Payment of Examination Fee
Follow the on-screen instructions after completing website registration, and pay the examination fee (JPY30,000) by credit cards or Pay-easy. Please note that applicants have to pay transaction fee (JPY 500) besides
examination fee (JPY 30,000).
Payment of examination fee is not required for applicants who wish to enroll on a Japanese Government(Monbukagakusho: MEXT) Scholarship, a Chinese Government (China Scholarship Council: CSC)
Scholarship, or a Hokkaido University President’s Fellowship.
Those who apply under 2. Qualifications of Applicants (3) (4) or (5), must pay the examination fee after
５

qualification review.
Examination fee is non-refundable unless:
1) The application was not made.
2) Application documents were not accepted due to the documents being incomplete.
3) Double-payments were made.
Please acknowledge that it takes considerable time for processing refund.
Please keep the receipt, as it is required when claiming the refund to Student Affairs Office.
(5) Important Notice1) Online registration, payment of examination fee, and submission of application documents by post
must be completed by (2) Submission Deadline of Application Documents.
2) Printers and Email address are required for online registration.
3) Application documents submitted will not be returned.
4) Application documents should be sent to Student Affairs Office by safe and reliable methods such as
Express Mail Service (EMS). Late arrival due to postal accident will not be accepted.
5) To check your Internet connection, we will conduct a connection test on Tuesday, June 25, between
9:00 and 17:00 (Japan Standard Time). The detailed date and time will be notified to your e-mail address.
(6) Qualification Review
Those who apply under 2. Qualifications of Applicants Qualification (3) (4) or (5), must undergo
individual qualification review. Applicants have to contact the prospective supervisor by email.
Applicants have to send the original 2) Application Documents for Qualification Review 1-7 to Student
Affairs Office by post.
1) Application Period for Qualification Review
Submission Deadline of Application Documents for Qualification Review:
17:00 (Japan Standard Time), Monday, 27 May, 2024
Original application documents for qualification review must arrive at Student Affairs Office by post.

６2) Application Documents for Qualification Review
12
3

Application Form for Sent by the prospective supervisor by email. Fill in your information. Print
Qualification Review
them out on A4 size paper. Paste your photograph in the space provided.
(Full-face, applicant’s name printed on back, 4cm x 3cm, taken within 3months before 1) Submission Deadline of Application Documents for
Qualification Review.)
Must be issued by a university/college president or Dean, and submit a new
Academic Transcripts
original. Copy not accepted.
Certificate of (expected) Must be issued by a university/college president or Dean, and submit a new
Graduationor original. Copy not accepted.
(For graduates, be sure that the certificate includes information on your degree).
Completion*Those who graduated or will graduate from a university in China (excluding
Taiwan, Hong Kong and Macau) must submit the following documents in addition
to a Certificate of (Expected) Graduation (Completion) .
Graduates:
a. Online Verification Report of Higher Education Qualification Certificate（教育部学子注册 案表）b. A certified copy of Graduation Diploma（）and Degree Diploma（学位）that has been authorized by a university/college
Expected Graduates :a. Online Verification Report of Student Record（教育部学籍在告）Obtain documents “a” above by requesting it at “中国高等教育学”:
http://www.chsi.com.cn/xlcx/bgys.jsp.
Also be sure that there are 15 or more days left until the expiration date of the online
verification at the time of its submission.

4

Copy of Passport

5

Proof
of
English If English is not your first language: Copies of the following test results as
proof of English language proficiency taken within 2 years before the deadline
Language Skillsof application. (e.g. TOEFL-ITP, TOEFL-iBT（Home Edition acceptable）,
TOEIC Listening & Reading Test, IELTS Academic) For TOEIC Listening &Reading Test taken after April 2024, a printout of the PDF version of theofficial digital certificate is acceptable.
(If applicable)
Applicants from EEA must confirm the Handling of Personal Information on
Consent to Transfer and page 8 and submit the Consent. The form will be sent by the prospective
supervisor by e-mail.
Process Personal Datai) Those who apply under 2. Qualifications of Applicants (3)OthersCertificate of research experience issued by the enrolled university or
research institute.
ii) Those who apply under 2. Qualifications of Applicants (5)1. Research proposal. (800 words in English.)
2. Letter of Recommendation issued by supervisors or mentors of theenrolled university or research institute. (Free format.)
3. Certificates of academic ability equivalent to or greater than university
graduates, or statement of academic achievements. (Such as scientific papers,
books, and reports.)iii) Other documents may be designated by the prospective supervisor asneeded.

6

7

The page which your photo and passport number are shown.

3) Announcement of Results for Qualification Review
Results for qualification review will be notified to applicants by email by Friday, 7 June, 2024.
７

After qualification review, eligible applicants have to see (1) How to Apply, and do necessary procedures.
Applicants have to send the original Application Documents (3) 1) Application Form and Curriculum Vitae, 2)
Photo ID Card, and 4) Statement of Purpose to Student Affairs Office by post.

(7) Application Documents should be submitted to:Student Affairs Office
Hokkaido University Graduate School of Medicine
Kita 15 Nishi 7, Kita-Ku, Sapporo, 060-8638 JAPAN
Email: d-tanto@med.hokudai.ac.jp
4.

Selection Procedure
Admission shall be determined individually based on the comprehensive evaluation of internet videointerview (Zoom interview), and application documents submitted. Applicants must prepare equipment such asa web camera and the proper network environment for internet video interview by 5. Examination Date and
Time.
5.

Examination Date and Time
Designated date between Tuesday, July 2, 2024 or Wednesday, July 3, 2024. Detailed examination date andtime will be notified to applicants by email.
6.

Announcement of AcceptanceA Letter of Acceptance will be sent to each successful applicant by email at 10:00 (Japan Standard Time)
on Friday, 12 July, 2024. And the original letter of acceptance will also be sent by post. Any inquiry bytelephone or other source concerning examination result will not be accepted.

7. Enrollment Procedure(1) Registration Period
From 9:00 (Japan Standard Time), Wednesday, 11 September, 2024 to 17:00 (Japan Standard Time),
Friday, 13 September, 2024, excluding Saturday and Sunday(2) Enrollment and Tuition Fees
1) Enrollment Fee: JPY 282,000 (estimate)
Please note that it is not required for those who is granted a Japanese Government(Monbukagakusho: MEXT) Scholarship, a Chinese Government (China Scholarship Council: CSC)
Scholarship, or a Hokkaido University President’s Fellowship.
2) Tuition Fee: JPY 267,900 per half year (JPY 535,800 per year) (estimate)
Tuition of the first period should be paid using the bank remittance form sent from Hokkaido
University Graduate School of Medicine in middle of November 2024.
If the fee is revised, the new one will be adapted accordingly.
3）Payments of admission and tuition fees could be exempted or postponed. Further information will be
notified to successful applicants.

8. Important Notice(1) Before filling in a column of the preferred field on the application for enrollment in 3. (3) 1)
Application Form and Curriculum Vitae, refer to the following URL
https://www.med.hokudai.ac.jp/en/faculty/ and consult your prospective supervisor about researchcontents and plan.
(2) Incomplete application documents and/or lack of documents will not be processed.
(3) Submitted documents are considered final and revision after submission will not be accepted.
(4) Enrollment may be cancelled at any time, should submitted documents be found to contain false
information.
８(5) Application documents must arrive at Student Affairs Office by post. Consider postal service situationand send early enough to be arrived. Late arrival after 3. (2) Submission Deadline of Application
Documents will not be accepted.
(6) Any inquiry regarding examination and enrollment should be sent by email.

9. Use of Personal Information(1) All personal information collected by Hokkaido University will be completely protected in compliancewith the Act on the Protection of Personal Information Held by Independent Administrative Agencies, andthe EU General Data Protection Regulation (GDPR) pursuant to the Hokkaido University Regulations on
Personal Information Management.
(2) Your name, address, and other personal information you provide to the university through application andindividual admissions screening processes will be used solely for ① enrollee selection (application
processing and the screening process), ② the announcement of exam results, ③ admission procedures,④ surveys and research on enrollee selection methods, and ⑤ other related processes.
(3) The personal information in section (2) above will also be used after enrollment, only for those who pass
the exam, for processes related to ① academic affairs (registration, academic guidance), ② student
support services (health management, scholarship applications, dorm admission selection, welfare
services, etc.), ③ job search support services, ④ tuition, ⑤ use of the university library, ⑥ use of
information education facilities, ⑦ confirming your safety and communication in a disaster or
emergency situation, and ⑧ public relations (distributing newsletters, information on events, etc.).
(4) Personal information contained in exam results will be used to conduct surveys and research on enrollee
selection methods.
(5) For recruiting purposes, when we receive a request for information from the Hokkaido University Frontier
Foundation (Kita 8 Nishi 5, Kita-ku, Sapporo, Hokkaido; Tel: +81-(0)11-706-2017) or Hokkaido
University Athletic Union (Kita 17, Nishi 7, Kita-ku, Sapporo, Hokkaido; Tel: +81-(0)11-716-4815), theonly personal information listed in section (2) will be provided for use within the scope of thatorganization’s activities.
(6) The personal information set forth in (2) will be retained for five years from the next academic year of ouracquirement.
(7) The university shall use Article 6, Paragraph 1 (a) of the EU GDPR as the basis for handling personal
information and obtaining consent to use it. Personal information will only be used for the purpose forwhich consent has been given, except when required by laws and regulations.
(8) The consent set forth in (7) may be revoked at any time. However, this does not affect the legal handling of
personal information before consent was revoked.
(9) Individuals who provide personal information may make the following requests to the university based on
the EU GDPR and related laws and regulations:① Disclosure of personal information，② Correction of personal information，③ Erasure of personal
information，④ Limitation of the handling of personal information, ⑤ Objection to the handling of
personal information，⑥ Transfer of personal information to other service providers(10) If you have provided personal information within the European Economic Area, you may file an objection
to a supervisory authority in accordance with Article 51, Paragraph 1 of the EU GDPR if you are
dissatisfied with the university’s handling of your personal information, etc.
(11) Some of the processes in (2)－(5) mentioned above may be outsourced by the university to a contracted
service provider (hereinafter referred to as “contractor”). All or some of the personal information provided
by applicants may be provided to the contractor only as needed to perform the tasks for which it has been
contracted.
(12) This university is subject to Japan’s Law for the Protection of Personal Information Retained by
Independent Administrative Institutions, but not subject to adequacy decisions by the European
Commission.
May 2024
Student Affairs Office
Hokkaido University Graduate School of Medicine
９Kita 15 Nishi 7, Kita-Ku, Sapporo, 060-8638, JAPAN
Phone: +81-(0)11-706-5018＊Japanese only

１０

※Organization of the Graduate School of Medicine and main research contents
Academic advisor

Department
Molecular Biology

Professor

Biochemistry
Medical Chemistry

AnatomyProfessor

Anatomy and Embryology Professor
Histology and Cytology

Professor

Cell Physiology

Professor

Physiology
Systems Neuroscience

Professor

Neuropharmacology

Professor

Cellular and Molecular
Pharmacology

Professor

Pharmacology

Pathology

Professor

Pathology
Cancer Pathology

Professor

Professor
Diagnostic Pathology

Associate
Professor

Immunology

Professor

Microbiology and
Infectious Diseases

Professor

HygieneProfessor

Public HealthProfessor

Forensic Medicine

Professor

Health Care Policy

Professor

Microbiology and
Immunology

Biostatistics
Social Medicine

Professor
Associate
Professor

Medical Education andGeneral Medicine

Professor

Regulatory Science

Professor

Research contents
1. Cell integrity based on cellular metabolisms and nuclear geometry

HATAKEYAMA Shigetsugu 2. Nano structures controlling organelle dynamics

3. Molecular bases of cancer therapeutic resistance
1．Ubiquitin system in protein degradation
HATAKEYAMA Shigetsugu 2．Intracellular signal in cancer and immune system
3．Functional analysis of proteins/lipids by mass spectrometry
1．Visualization of expression and localization of neural signaling molecules
WATANABE Masahiko
2．Glial roles in neural development and function
3．Molecular mechanisms for synaptic circuit development
1. Anatomy and function of central nervous system
FUJIYAMA Fumino
2. Elucidation of Parkinson's disease
1．Visualization of cell functions using fluorescence bioimaging
2．Spatiotemporal regulation of intra- and intercellular signal transduction
OHBA Yusuke
3．Regulation of membrane dynamics
4．Development and application of fluorescent biosensors
1．Neural control of voluntary movements
2．Functional analysis of the frontal cortex
TANAKA Masaki
3．Functional analysis of the basal ganglia
4．Functional analysis of the cerebellum
1．Neuropharmacological studies of the histaminergic nervous system
2．Analysis of neuropeptides in wakefulness
3．Drug development targeting sleep disorders
4．Molecular biology of hyaluronic acid
YOSHIKAWA Takeo
5．Optical imaging of learning-induced neural circuit reorganization
6．Neural basis of autism spectrum disorder and social behavior
7．Cognitive mechanisms of virtual reality
8．Development of novel neural activity imaging techniques
1. Analysis of the effects of tobacco smoke components on cellular functions
YOSHIKAWA Takeo
2. Research on neutrophil activation and its control mechanism
3. Elucidation of toxicological mechanisms and pathophysiological effects of environmental chemicals
1．Research on inflammation and cancer
2．Research on inflammation and tissue regeneration
3．Mechanisms of autoimmune and inflammatory diseases
TANIGUCHI Koji
4．Research on tight junction
5. Development of new cancer-on-chip to elucidate the pathophysiology of intractable cancer
6．Human pathology and surgical pathology
1. Research on diagnostic and surgical pathology
2. Cancer progression, cancer stem cells, and therapeutics.
3. Profiling analysis of various diseases.
TANAKA Shinya
4. Bioimaging and rapid-immunohistochemistry.
5. Biomaterial for analysis of cellular reprogramming.
6. NGS-based research on brain tumor and sarcoma.
7. Student-oriented innovative research.
1．Diagnostic surgical pathology (including cytopathology)
TANAKA Shinya
2．Application of molecular studies in diagnostic pathology
3．Quality control and standardization in pathology laboratories
TOMARU Utano
4．Clinicopathologic analysis of human malignancy
1. Host protection mediated by TLR and NLR family proteins
2. Role of the innate immune system in the onset of infection and inflammatory diseases
3. Nod2-dependent intestinal mucosal homeostasis and pathogenesis of Crohn’s disease
KOBAYASHI Koichi
4. CITA/NLRC5: a key regulator of MHC class I genes
5. Mechanisms of immune evasion by cancers
6. Development of novel biomarkers and immunotherapies for cancer patients
7. Vaccine development against cancer and coronaviruses using a novel vaccine technology
1．Studies on viral and host factors involved in the propagation of hepatitis virus (HBV, HCV)
2．Studies on the mechanism of pathogenicity of virus infection through molecular
FUKUHARA Takasuke
biological analysis and animal experimentation
3．Studies on the diagnosis and drug discovery of viral infection (Coronavirus, Flavivirus)
4．Epidemiological and molecular biological studies on zoonotic diseases (Hantavirus, Flavivirus)
1. Environmental epidemiological studies
2. Quasi-experimental assessment of population-level health interventions (interrupted time series, instrumental variables
3. Emergency preparedness for climate change, natural disasters, and infectious diseases in healthcare facilities
UEDA Kayo
4. Epidemiological study on behavioral and psychological symptoms of dementia
5. Assessment of health effects of climate change and global environment
1．Studies on diet, physical activity, social environment and physical and mental health in adults and elderly
2．Study of factors related to the health and development of children from conception
TAMAKOSHI Akiko
3．Research on infertility prevention and treatment support
4. Study on post COVID-19 condition
1．Studies on medico-legal diagnosis of cause of death, postmortem interval, wounds, asphyxia, identification
MATOBA Kotaro
and postmortem CT diagnosis.
2．Studies on the mechanisms of generation concerning exogeneous unusual findings.
1．Study on measures of healthcare and welfare for community-dwelling people in low fertility and ageing
society
TAMAKOSHI Akiko
2．Epidemiological study on HIV/AIDS/STIs and other includes Zoonosis and Life-Related diseases
3．Study on risk perception/management/communication for infectious diseases
4．Development of indicators to measure/raise community awareness against diseases
1. Multivariate survival analysis
HATAKEYAMA Shigetsugu 2. Development and evaluation methodology for diagnostic method and clinical prediction model
3. Development and application of clinical trial design
YOKOTA Isao
4. Joint model of longitudinal data with flexibility
5. Clinical epidemiology using big-data and public database
1． Development of innovative teaching methods and materials
2． Development of innovative evaluation methods
TAKAHASHI Makoto
3． Studies on factors that affect learning behavior
4. Studies on factors that affect physicians' carrier selection
1． Studies on data necessary for the development of advanced biological medicines
ARATO Teruyo
2． Studies on developmental strategy for orphan drugs
3． Studies on post marketing surveillance of pharmaceuticals and medical devices

Academic advisor

Department
Translational Research
Manegement

Professor

SATO Norihiro

Patient Safety

Professor

NASUHARA Yasuyuki

Health Data Science

Professor

ITO Yoichi

Clinical Genetics andMedical Ethics

Professor

YAMADA Takahiro

Respiratory Medicine

Professor
Professor

KONNO Satoshi
SAKAKIBARA Jun

Rheumatology,
Endocrinology and
Nephrology

Professor
Professor

ATSUMI Tatsuya
NISHIO Saori

Gastroenterology andHepatology

Professor
Professor

SAKAMOTO Naoya
ONO Shoko

Professor
Associate
Professor

ANZAI Toshihisa
NAGAI Toshiyuki

Medical Oncology

Professor

KONNO Satoshi

Hematology

Professor

TESHIMA Takanori

Professor

ASAKURA Satoshi

Cardiovascular Medicine

Internal Medicine

Health Care Medicine

Research contents
1．Methodology for clinical research
2．Data manegement of clinical trial
3．Manegement of cell processing for cell therapy and regenerative medicine
4．Methodology for translational research support
1. Research on the methodology about system approach to patient safety
2. Research on the methodology for cultivating talented risk managers in hospitals
3. Research on the methodology about standardization of medical accident investigation
1. Studies on the methodology of clinical trials
2. Studies on the methodology of drug safety data analysis
3. Studies on the multivariate data analysis
1. research on disclosure of secondary findings in genomic medicine
2. Research on newborn screening and genetic counseling
3. Research on tele-medicine in genetic counseling
4. Research on genetic counseling in presymptomatic genetic testing
5. Research on providing systems for prenatal genetic testing and genetic counseling
1. Prospective cohort studies of asthma and/or COPD
2. Research on molecular mechanisms, diagnosis, and treatment of thoracic malignancies
3. Research on molecular mecahnisms of chronic airway disease and/or diffuse lung disease
4. Basic/clinical research on pulmonary hypertension and cardiac sarcoidosis
5. Basic / clinical research on respiratory infectious diseases
1．Basic and clinical research on autoimmune disorders
2．Research on the pathophysiology, diagnosis and therapy of diabetes, obesity and dyslipidemia
3．Research on the pathophysiology and therapy of endocrine diseases
4．Basic and clinical research on renal diseases
1．Research for pathophysiology, diagnosis and treatment of liver diseases
2. Research for pathophysiology, diagnosis and treatment of pancreatobiliary diseases
3. Research for pathophysiology, diagnosis and treatment of malignant tumor of digestive system
4．Research for pathophysiology and treatment of inflammatory bowel diseases
5．Research for pathophysiology, diagnosis and treatment of digestive diseases
1．Reasearch on pathophysiology, diagnosis, and treatment for ischemic heart disease
2．Molecular biological and clinical reasearch on pathophysiology and treatment for heart failure
3．Reasearch on etiology, diagnosis, and treatment for cardiomyopathy
4．Reasearch on molecular and genetic basis, diagnosis, and treatment for lifestyle disorder
5．Reasearch on etiology, diagnosis, and treatment for arrhythmia
6．Development of non-invasive technique for diagnosis of heart disease
1．Research on diagnosis and treatment of malignant tumors
2．Research on molecular pathophysiology, diagnosis and treatment of lung cancers and mediastinal tumors
3．Research on molecular pathophysiology, diagnosis and treatment of tumors of the digestive organs
4．Research on cancer drug therapy
5．Research on molecular targeting therapy of cancer
6． Research on genome analysis, companion diagnostics and precision medicine of cancer
1．Research on molecular pathogenesis, diagnosis, treatment of hematological malignancies
2．Basic and clinical research to improve outcome of hematopoietic stem cell transplantation and immune cell
3．Basic research to understand cellular & molecular biology of hematopoiesis
4. Basic and clinical research on cell therapies against viral infections and malignant diseases
5．Pathogenesis, diagnosis, and treatment of immunodeficiencies, including AIDS
6．Reserch to improve safety and efficacy of blood transfusion
7. Research on platelet function, blood coagulation and fibrinolysis
1．Research for impaired health caused by stresses
2．Research for evidence based medicine in health examination
3．Research for occupational mental health
4．Research for adolescent mental health

Clinical Cancer Genomics

Professor

KINOSHITA Ichiro

Radiation Oncology

Professor

AOYAMA Hidefumi

Diagnostic Imaging

Professor

KUDO Kohsuke

Radiology

5．Research for therapeutic interventions of mental disorders
1. Research for cancer genomics
2. Research for genomic abnormality of cancer
3. Research for epigenetic alteration of cancer
4. Development of novel biomarker on cancer
5. Research for molecular targeted therapy on cancer
1．Research for external irradiation
2．Research for high precision X ray therapy
3．Research for Particle therapy and Proton therapy
4．Research for medical physics
5. Research for radiobiology for radiotherapy
1．Diagnostic radiology using CT, MRI, ultrasound, and nuclear medicine
2．Vasicular imaging and interventional radiology
3．Radioisotope treatment
4．Imaging analysis of tracer kinetics and artificial intelligence
5．Synthesis of contrast media and radiopharmaceuticals
6．Molecular imaging using stable isotopes and radio isotopes

Academic advisor

Department

Gastroenterological
Surgery I

Gastroenterological
Surgery II

Professor

Professor
Associate
Professor

TAKETOMI Akinobu

HIRANO Satoshi
SHICHINOHE Toshiaki

Surgery
Professor
Renal and Genitourinary
Surgery
Associate
Professor

TAKETOMI Akinobu
ABE Takashige

Cardiovascular Surgery

Professor

WAKASA Satoru

Breast Surgery

Professor

TAKAHASHI Masato

Thoracic Surgery

Professor

KATO Tatsuya

Anesthesia andPerioperative Medicine

Professor

MORIMOTO Yuji

Acute and Critical Care
Medicine

Professor

MORIMOTO Yuji

Orthopedic Surgery

Professor

IWASAKI Norimasa

Plastic andReconstructive Surgery

Professor

YAMAMOTO Yuhei

Rehabilitation Medicine

Professor

MUKAINO MasahikoSports Medicine

Professor

KONDO Eiji

Anesthesiology andCritical Care
Medicine

Reconstructive
Surgery andRehabilitation
Medicine

Research contents
１．Basic research and treatment on the surgical GI tract and HPB diseases.
２．Development of endoscopic and/or robotic surgery for the GI tract and HPB diseases.
３．Study for the pathogenesis and management of transplant immunology
４．Research for the improvement of organ preservation
５．Clarification of pathogenesis and development of new strategy of cell transplantation
６．Artificial Intelligence (AI) applied research in the field of gastroenterological surgery
７．Study of the surgical education and surgical training
８．Basic research and treatment on pediatric surgical oncology and pediatric hepato-biliary diseases
９．Basic and clinical research on the function of pediatric digestive system
1．Clarification of pathophysiology and development of surgical treatments of themalignancy of the digestive system
2．Development of endoscopic surgery and its devices
3．Clinical researvh for perioperative management of highly invasive digestive surgeries
4. Study for multidisciplinary treatment of pancreato-biliary cancer
5．Molecular research on biomarkers associated with oncological malignancy
6．Exploring translational research on immunotherapy
7．Analysis of immune responses in tumor microenvironments
8．Study of gene therapy for intractable cancers
9. Study for surgical education
10. Study for bariatric and metabolic surgery
1．The mechanism of development of detrusor overactivity associated with lower urinary tract obstruction
2．Neural transmitted pathway at the bladder stimulation
3．The development of chronic rejection in transplanted kidney
4．The analysis of immunology in renal transplantation and development of the treatment of
immunological regulation
5．The mechanism of carcinogenesis and progression in kidney cancer
6．The mechanism of metastasis and progression of urothelial cancer
7．QOL study on the treatment of prostate cancer
8．The development of minimal invasive surgery
1．Research on surgery for severe heart failure
2．Research on surgery for functional mitral regurgitation
3．Research on myocardial protection
4．Research on cold preservation and autophagy in the heart
5．Metabolic disturbances in atrial fibrillation
6．Endovascular stent graft therapy for aortic diseases
1．Research on biological characteristics in breast cancer
2．Research on endocrine therapy in breast cancer
3．Research on mechanisms of breast cancer development and prevention
4. Research on the development of new breast cancer screening methods
5. Research on the development of breast cancer surgical methods
6. Research on the perioperative drug therapy for breast cancer
7. Research on drug therapy for metastatic breast cancer
8. Research on hereditary breast cancer
1．Development of minimally invasive thoracic surgery
2．Surgery in multimodality thearapy for lung cancer
3．Lung transplantation
4．Photodynamic therapy using nanoparticle for thoracic malignant tumors
cancer
6. Photoimmunotherapy for lung cancer
7. Therapy for malignant mesothelioma and dissemination of cancer
1．Cerebral protection and resuscitation
2．Care and Cure for the whole body against invasive biological stress
3．Neurotoxicity by anesthetics
4．Mechanism of postoperative cognitive dysfunction
5．Mechanism and treatment of pain
6．Mechanism of respiratory cycle and effect of drugs
7． Hyperbaric oxygen therapy
8．Patient management system in the operating room and the medical economics
1．Elucidation of the pathophysiology of host responses to various insults and establishment of their control
2．Multiple organ dysfunction syndrome –pathophysiology and treatment3．Critical care medicine
4．Cardiopulmonary cerebral resuscitation
5．Toxicology
6．Disaster medicine
7．Medical, transportation, and information system for acute medicine
8．Traumatology
1．Elucidation of pathology and development of therapeutic strategy for arthritis
2．Identification of role of glycans in bone and cartilage metabolism
3. Study of pathology and development of therapeutic strategy for osteoporosis
4．Clarification of pathology and development of therapeutic strategy for intervertebral disc degeneration
5. Biomechanical study for pathology and treatment options of musculoskeletal diseases
6. Research about pathology and treatment strategy for spinal cord and peripheral nerve diseases
7．Development of novel analytic tools for musculoskeletal diseases using AI
8．Research about genetic and epidemiologic aspects of musculoskeletal diseases
9. Development of regenerative medicine for musculoskeletal diseases
1．Translational research in wound healing
2．Translational research in treatment of keloid
3．Development of surgical technique in free tissue transfer
4．Basic research in surgical oncology
5．Translational research of angiogenesis of vascular and lymphatic vessel
6．Regenerative medicine based on tissue engineering method
7．Development of therapeutic technique in cranio-maxillo-facial surgery
1. Research on motion analysis of movement disorders
2. Research on activity monitoring
3. Research on functioning statistics for daily life
4. Research on telerehabilitation
5. Research on assessment methods for cognitive impairment
1. Motion analysis of athletes for performance improvement
2. Development of reconstruction surgery for osteoarthritis
3. Tissue regeneration of joints
4. Elucidation of remodeling mechanism of soft tissue
5. Medical application of synthetic polymer gel
6. Development of advanced treatment technology for musculoskeletal disorderAcademic advisor

Department

Pediatrics

Professor
Professor

MANABE Atsushi
CHO Yuko

Reproductive andDevelopmental
MedicineSensory Organ
Medicine

Neurological
DisordorObstetrics andGynecology

Professor

WATARI Hidemichi

Dermatology

Professor

UJIIE Hideyuki

Professor
Otolaryngology−Headand Neck Surgery

HOMMA Akihiro

Associate
Professor

NAKAMARU Yuji

Ophthalmology

Professor

ISHIDA Susumu

Psychiatry

Professor

YABE Ichiro

Neurosurgery

Professor

FUJIMURA Miki

Research contents
1. Establishing methods for early diagnosis of primary immunodeficiency diseases.
2. Molecular epidemiological studies on macrolide-resistant mycoplasma pneumoniae
3. Clinical and molecular study for diagnosis and management in pediatric hematology and oncology.
4. Clinical and molecular study in pediatric stem cell transplantation and cell therapy.
5. Molecular analysis of pediatric endocrine disease.
6. Pathological analysis and therapeutic development using neurological disease model animals.
7. Histopathological analysis on the role of activated glomerular parietal epithelial cell in childhood kidney
8. Development of a Mitochondrial Drug Delivery System for Myocardial Regeneration Therapy.
9. Study to improve outcome of neonatal chronic lung disease.
10. Basic and Clinical study in inborn errors of metabolism.
1．Basic studies on the physiology of fetus and amnion
2．Clinical studies on the antenatal diagnosis and fetal therapy
3．Studies on the development of new strategy for the management of complicated pregnancies
4．Clinical studies on the treatment of infertility
5．Intrafollicular physiology
6．Molecular mechanism of genesis and metastasis of uterine cancer
7．Chemoresistance of female reproductive cancer
8．Molecular mechanism of placental growth and differentiation
9. Development of novel molecular-targeting therapy for ovarian cancer
10. Establishment of new effective screening method for cervical cancer
1．Molecular biological research of epidermis
2．Research on pathophysiology, diagnosis and treatment of genetic skin disorders
3．Research on pathophysiology, diagnosis and treatment of autoimmune blistering skin diseases
4．Research on pathophysiology, diagnosis and treatment of malignant skin tumors
5．Research on pathophysiology, diagnosis and treatment of atopic dermatitis
6．Research on tissue engineering and wound healing
7．Research on novel therapeutic modalities for genetic skin disorders
1． Basic research and clinical analysis for pathogenesis of sensorineural hearing loss
2． Basic research and clinical analysis of sensorineural hearing loss by viral infection
3． Basic research and clinical analysis of nasal allergy
4． Basic research and clinical analysis of Eosinophilic chronic rhinosinusitis
5． Immunological approach for head and neck cancer
6． Basic research and clinical analysis of chemotherapy for head and neck cancer
7．Molecular biologic studies on head and neck cancer
1．Retinal cell biology
2．Ocular Immunology and inflammation
3．Ocular neuroprotection
4．Ocular oncology and pathology
5. Pathophysiology and treatment of ocular surface disease
6．Ocular circulation and metabolism
1．Psychopathology of psychiatric diseases
2．Development of new psychotherapy techniques
3．Development of new diagnostic techniques and new treatment of epilepsy
4．Molecular genetic study of psychiatric diseases
5．Development of animal models of psychiatric diseases and neuroscience
6．Development of new psychotropic drugs and psychopharmacology
7．Neuroimaging in psychiatric diseases
8．Neurophysiological and neuropsychological study of psychiatric diseases
1． Basic and clinical research on malignant glioma
2．Basic and clinical research on cerebrovascular disorders
3． Basic and clinical research on spinal cord disorders
4．Translational research on CNS regeneration
5． Surgical anatomy of skull base surgery
6． Genetic research on cerebrovascular disorders
7．Cerebral blood flow and metabolism
8．Clinical research on pediatric neurosurgery

Academic advisor

Department

Neurology

Medical Biology

Professor

YABE Ichiro

Neurobiology

Professor

KAMIYA Haruyuki

Immunobiology

Professor

SEINO Kenichiro

Psychoimmunology

Professor

MURAKAMI Masaaki

Molecular Mechanisms

Professor

NODA Nobuo

Stem Cell Biology

Professor

KONDO Toru

Biomedical Oncology

Professor

SONOSHITA Masahiro

Immunology

Pathological
Oncology

Research contents
1．Molecular biology and genetics for neurological disorders
2．Immunohistochemistry of muscles and peripheral nerves
3．Basic studies for the disease mechanism and therapeutic approach in neuro-immunological disorders
4． Biomarkers in neurological disorders
5．Clinical neuroelectrophysiology
6．Cogitive brain function
7．Neuroepidemiology
1．Neurobiology of axon
2． Neurobiology of synapse
1．Tumor Immmunology
2．Transplant Immunology (including studies of xenotransplantation using gene modified pigs)
3．Study and development of cell therapy for inflammatory diseases
1. Molecular mechanism for T cell-specific autoimmune disease development by the gateway reflexes
2. Bioelectronic medicine by the gateway reflexes and the VNS
3. Molecular mechanisms underlying inflammation development via the IL-6 amplifier activation
4. Research for functional roles of SNPs asscoiated with chronic inflammatory diseases (the IL-6 amplifier)5. Development of novel drugs and biomarkers for diseases associated with chronic inflammation (the IL-6
1. Molecular mechanism of autophagy
2. Molecular mechanism of life phenomena regulated by liquid-liquid phase separation
3. Elucidating the molecular functions of biomolecules based on their structure
1． Molecular mechanism involved in the maintenance and differentiation of neural stem/precursor cells
2．Molecular mechanism of neural stem/precursor aging
3．Characterization of cancer stem cells and analysis of their therapeutic targets
4．Relationship between neural stem cells and age-related disorders.
1. Studying how cancers develop
2. Elucidating the mechanisms of how drug resistance occurs in cancer
3. Generating novel anti-cancer therapeutics