事業推進担当者・若手研究者の研究業績（原著論文）

平成19年度（2007−2008年）

平成19年度には拠点を形成する５専攻全体で236報の英文学術論文（IFの合計：658.247）を発表した。
（以下は事業推進担当者および若手研究者が発表した主な原著論文）

1. I. Abe, H. Morita, S. Oguro, H. Noma, K. Wanibuchi, N. Kawahara, Y. Goda, H. Noguchi, and T. Kohno; Structure-based engineering of a plant
type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone, J. Am. Chem. Soc. 129, 5976-5980, 2007.
2. I. Abe, H. Tanaka, T. Abe, and H. Noguchi: Enzymatic formation of unnatural cytokinin analogs by adenylate-isopentenyl-transferase frommulberry, Biochem. Biophys. Res. Commun. 355, 795-800, 2007.
3. K. Abe, T. Suzuki, M. Ijiri, Y. Koyama, M. Isemura, and N. Kinae: The anti-fibrotic effect of green tea with a highcatechin content inthegalactosamine-injured rat liver. Biomed. Res. 28, 43-48, 2007.
4. M.-R. Ahn, K. Kunimasa, T. Ohta, S. Kumazawa, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, and T. Nakayama: Suppression of tumor-induced
angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett.
252, 235-243, 2007.
5. P. Auewarakul, O. Suptawiwat, A. Kongchanagul, C. Sangma, Y. Suzuki, K. Ungchusak, S. Louisirirotchanakul, H. Lerdsamran, P. Pooruk, A.
Thitithanyanont, C. Pittayawonganon, C.-T. Guo, H. Hiramatsu, W. Jampangern, S. Chunsutthiwat, and P. Puthavathana: An avian influenza
H5N1 virus that binds to a human-type receptor. J. Virol. 81, 9950-9955, 2007.
6. Y. Deguchi, T. Toyoizumi, S. Masuda, A. Yasuhara, S. Mohri, M. Yamada, Y. Inoue, and N. Kinae: Evaluation of mutagenic activities of leachates
in landfill sites by micronucleus test and comet assay using goldfish. Mutat. Res. 627, 178-185, 2007.
7. R. Eguchi, H. Naitou, K. Kunimasa, R. Ayuzawa, Y. Fujimori, N. Ohashi, K. Kaji, and T. Ohta: Proteomic analysis of hypoxia-induced tube
breakdown of an in vitro capillary model composed of HUVECs: Potential role of p38-regulated reduction of HSP27. Proteomics, 8, 2897-2906,
2008.
8. T. Fukushima, S. Mitsuhashi, M. Tomiya, M. Iyo, K. Hashimoto, and T. Toyo'oka: Determination of kynurenic acid in human serum and its
correlation with the concentration of certain amino acids. Clin. Chim. Acta. 377, 174-178, 2007.
9. T. Furuta, Y. Kitamura, A. Hashimoto, S. Fujii, K. Tanaka, and T. Kan: Efficient synthesis of phenanthridinone derivatives via a domino coupling
process., Org. Lett. 9, 183-186, 2007.
10. T. Furuta, Y. Hirooka, A. Abe, Y. Sugata, M. Ueda, K. Murakami, T. Suzuki, K. Tanaka, and T. Kan: Concise synthesis of dideoxy-epigallocatechingallate (DO-EGCG) and evaluation of its anti-influenza virus activities. Bioorg. Med. Chem. Lett. 17, 3095-3098, 2007.
11. C. Fuse, Y. Ishida, T. Hikita, T. Asai, and N. Oku: Junctional adhesion molecule-C promotes metastatic potential of HT1080 humanfibrosarcoma. J. Biol. Chem. 282, 8276-8283, 2007.
12. T. Goda, K. Suruga, A. Komori, S. Kuranuki, K. Mochizuki, Y. Makita, and T. Kumazawa: Effects of miglitol, an a-glucosidase inhibitor, on
glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br. J. Nutr. 98,
702-710, 2007.
13. C.-T. Guo, N. Takahashi, H. Yagi, K. Kato, T. Takahashi, S.-Q. Yi, Y. Chen, T. Ito, K. Otsuki, H. Kida, Y. Kawaoka, K.I.P.J. Hidari, D. Miyamoto, T.
Suzuki, and Y. Suzuki: The quail and chicken intestine have sialyl-Gal sugar chains responsible for the binding of influenza A viruses to humantype receptors. Glycobiology, 17, 713-724, 2007.
14. K.I.P.J. Hidari, S. Shimada, Y. Suzuki, and T. Suzuki: Binding kinetics of influenza viruses to sialic acid-containing carbohydrates. Glycoconj. J. 24,
583-590, 2007.
15. K. Honma, K. Mochizuki, and T. Goda: Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its
expression in mouse small intestine. Biochem. Biophys. Res. Commu. 357, 1124-1129, 2007.
16. K. Honma, K. Mochizuki, and T. Goda: Acute induction of histone acetylation on the jejunal sucrase-isomaltase gene by dietary fructose. Br. J.
Nutr. 100, 698-702, 2008.
17. K. Ichikawa, T. Urakami, S.Yonezawa, H. Miyauchi, K. Shimizu, T. Asai and N.Oku: Enhanced desensitization efficacy by liposomal conjugationof a specific antigen. Int. J. Pharm., 336, 391-395, 2007.
18. A. Ikari, M. Ito, C. Okude, H. Sawada, H. Harada, M. Degawa, H. Sakai, T. Takahashi, J. Sugatani, and M. Miwa: Claudin-16 is directly
phosphorylated by protein kinase a independently of a vasodilator-stimulated phosphoprotein-mmediated pathway. J. Cell Physiol. 214,221-229, 2008.
19. A. Ikari, C. Okude, H. Sawada, Y. Sasaki, Y. Yamazaki, J. Sugatani, M. Degawa, and M. Miwa: Activation of a polyvalent cation-sensing receptor
decreases magnesium transport via claudin-16. Biochim. Biophys. Acta. 1778, 283-290, 2008.
20. A. Ikari, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, and M. Miwa: TRPM6 expression and cell proliferation are up-regulated byphosphorylation of ERK1/2 in renal epithelial cells. Biochem. Biophys. Res. Commun. 369, 1129-1133, 2008.
21. A, Ikari, C. Okude, H. Sawada, T. Takahashi, J. Sugatani, and M. Miwa: Down- regulation of TRPM6-mediated magnesium influx bycyclosporine A. Naunyn Schmiedebergs Arch. Pharmacol. 377, 333-343, 2008.
22. S. Inagaki, J. Z. Min, and T. Toyo'oka: Prediction for the separation efficiency of a pair of enantiomers during chiral high-performance liquid
chromatography using a quartz crystal microbalance. Anal. Chem. 80, 1824-1828, 2008.
23. S. Inagaki, T. Noda, J. Z. Min, and T. Toyo'oka: Metabolic profiling of rat hair and screening biomarkers using ultra performance liquid
chromatography with electrospray ionization time-of-flight mass spectrometry. J. Chromatogr. A 1176, 94-99, 2007.
24. S. Inagaki, Y. Esaka, Y. Deyashiki, B. Uno, A. Hara, and T. Toyo'oka: Human liver dihydrodiol dehydrogenase 1-catalyzed reaction generating
9a,11b-prostaglandin F2 from prostaglandin D2 followed by micellar electrokinetic chromatography. J. Sep. Sci. 31, 735-740, 2008.

86

事業推進担当者・若手研究者の研究業績（原著論文）

25. T. Ishii, S. Ito, S. Kumazawa, T. Sakurai, S. Yamaguchi, T. Mori, T. Nakayama, and K. Uchida: Site-specific modification of positively-charged
surfaces on human serum albumin by malondialdehyde. Biochem. Biophys. Res. Commun. 371, 28-32, 2008.
26. T. Ishii, T. Yamada, T. Mori, S. Kumazawa, K. Uchida, and T. Nakayama: Characterization of acrolein induced protein cross-links. Free Radic. Res.
41, 1253-1260, 2007.
27. Y. Iwasaki, O. Saito, M. Tanabe, K. Inayoshi, K. Kobata, S. Uno, A. Morita, and T. Watanabe: Monoacylglycerols activate capsaicin receptor,
TRPV1. Lipids, 43, 471-83, 2008
28. T. Kan, Y. Kita, Y. Morohashi, Y. Tominari, S. Hosoda, H. Natsugari, T. Tomita, T. Iwatsubo, and T. Fukuyama: Convenient synthesis ofphotoaffinity probes and evaluation of their cross-linking abilities., Org. Lett. 9, 2055-2058, 2007.
29. T. Kan, Y. Kawamoto, T. Asakawa, T. Furuta, and T. Fukuyama: Synthetic studies on altemicidin: Stereocontrolled construction of the coreframework. Org. Lett., 10, 169-171, 2008.
30. Y. Katanasaka, T. Asai, H. Naitou, N. Ohashi, and N. Oku: Proteomic characterization of angiogenic endothelial cells ctimulated with cancercell-conditioned medium. Biol. Pharm. Bull. 30, 2300-2307, 2007.
31. M. Kato, H. Kinoshita, M. Inokita, Y. Hori, T. Hashimoto, T. Iwatsubo, and T. Toyo'oka: Analytical method for b-amyloid fibrils using CE-laser
induced fluorescence and its application to screening for inhibitors of b-amyloid protein aggregation. Anal. Chem. 79, 4887-4891, 2007.
32. Y. Kato, S. Ikushiro, R. Takiguchi, K. Haraguchi, N. Koga, S. Uchida, T. Sakaki, S. Yamada, J. Kanno, and M. Degawa: A novel mechanism forpolychlorinated biphenyl-mediated decrease in serum thyroxine level in rats. Drug Metab. Dispos. 35, 1949-1955, 2007.
33. Y. Kato, S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Aoki, S. Yamada, and M. Degawa: Hepatic UDP-glucuronosyltransferases responsible for
glucuronidation of thyroxine T4 in humans. Drug Metab. Dispos. 36, 51-55, 2008.
34. F. Kawamori, M. Hiroi, T. Harada, K. Ohata, K. Sugiyama, T. Masuda, and N. Ohashi: Molecular typing of Japanese Escherichia coli O157:H7
isolates from clinical specimens by multilocus variable-number tandem repeat analysis and PFGE. J. Med. Microbiol. 57, 58-63, 2008.
35. H. Kawanishi, T. Toyo'oka, K. Ito, M. Maeda, T. Hamada, T. Fukushima, M. Kato, and S. Inagaki: Hair analysis of histamine and several
metabolites in C3H/HeNCrj mice by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry(UPLC-ESI-TOF-MS): Influence of hair cycle and age. Clin. Chim. Acta. 378, 122-127, 2007.
36. Y. Kitamura, S. Yoshikawa, T. Furuta, and T. Kan: One-pot synthesis of carbazole via tandem Suzuki-Miyaura and amination reaction. Synlett,377-380, 2008.
37. M. Kojima, M. Sekimoto, and M. Degawa: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A
subfamily enzymes in Meishan pigs. Biochem. Pharmacol. 75, 1076-1082, 2008.
38. H. Kumagai, Y. Yamaguchi, S. Ohkawa, K. Yamada, R. Furuya, and T. Takita: Reply to E. Cereda and C. Pedrolli: The use of the GeriatricNutritional Risk Index (GNRI) as simplified nutritional screening tool. Am. J. Clin. Nutr. 87, 1967, 2008.
39. S. Kumazawa, R. Ueda, T. Hamasaka, S. Fukumoto, T. Fujimoto, and T. Nakayama: Antioxidant prenylated flavonoids from propolis collected in
Okinawa, Japan. J. Agric. Food Chem. 55, 7722-7725, 2007.
40. S. Kuranuki, K. Mochizuki, T. Tanaka, and T. Goda: The possible roles of homeobox protein, Cdx-2 for the expression of LPH gene during
postnatal development. Life Sci. 80, 795-799, 2007.
41. T. Kurihara , J. Z. Min, T. Toyo'oka, T. Fukushima, and S. Inagaki, Determination of fluorescence-labeled asparaginyl-oligosaccharide inglycoprotein by reversed-phase ultraperformance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Anal.
Chem. 79, 8694-8698, 2007.
42. S. Maruyama, H. Tsukada, S. Nishiyama, T. Kakiuchi, D. Fukumoto, N. Oku, and S. Yamada: In vivo quantitative autoradiographic analysis ofbrain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. J. Pharmacol. Exp. Ther. 325, 774-781, 2008.
43. T. Maruyama, H. Iizuka, Y. Tobisawa, T. Shiba, T. Matusda, K. Kurohane, and Y. Imai: Influence of local treatments with capsaicin or allyl
isotiocyanate in the sensitization phase of an FITC-induced contact sensitivity model. Int. Arch. Allergy Immunol. 143, 144-154, 2007.
44. K. Matsuoka, C. Takita, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K.I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, K. Hatano, and D.
Terunuma: Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors. Bioorg. Med. Chem.
Lett. 17, 3826-3830, 2007.
45. J. Z. Min, T. Toyo'oka, T. Kurihara, T. Fukushima, and S. Inagaki: Fully automated two-dimensional high-performance liquid chromatography
with electrospray ionization time-of-flight mass spectrometry for the determination of oligosaccharides in glycopeptides after enzymic
fluorescence labeling. J. Chromatogr. A 1160, 120-127, 2007.
46. E.J. Mitacek, K.D. Brunnemann, M. Suttajit, L.S. Caplan, C.E. Gagna, K. Bhothisuwan, S. Siriamornpun, C.F. Hummel, H. Ohshima, R. Roy, and N.
Martin: Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, andnitrosodimethylamine. Nutri. Cancer, 60, 196-203, 2008.
47. S. Mitsuhashi, T. Fukushima, M. Tomiya, T. Santa, K. Imai, and T. Toyo'oka: Determination of kynurenine levels in rat plasma by
high-performance liquid chromatography with pre-column fluorescence derivatization. Anal. Chim. Acta. 584, 315-321, 2007.
48. S. Mitsuhashi, T. Fukushima, K. Arai, M. Tomiya, T. Santa, K. Imai, and T. Toyo'oka: Development of a column-switching high-performance liquid
chromatography for kynurenine lenantiomers and its application to a pharmacokinetic study in rat plasma. Anal. Chim. Acta. 587, 60-66, 2007.
49. D. Miyamoto, S. Hasegawa, N. Sriwilaijaroen, S. Yingsakmongkon, T. Suzuki, K.I.P.J. Hidari, T. Takahashi, C.-T. Guo, Y. Sakano, and Y. Suzuki:
Clarithromycin inhibits progeny virus production from influenza virus – Infected host cells. Biol. Pharm. Bull. 31, 217-222, 2008.
50. K. Mochizuki, N. Sakaguchi, S. Takabe, and T. Goda: De-phosphorylation of TRα-1 by p44/42 MAPK inhibition enhances T3-mediated GLUT5
gene expression in the intestinal cell line Caco-2 cells. Biochem. Biophys. Res. Commu. 359, 979-984, 200787

事業推進担当者・若手研究者の研究業績（原著論文）

事業推進担当者・若手研究者の研究業績（原著論文）

51. K. Mochizuki, H. Kawai, H. Mochizuki, M. Shimada, S. Takase, and T. Goda: Fatty acids in component of milk enhance the expression of thecAMP-response-element-binding-protein-binding-protein (CBP)/p300 gene in developing rats. Br. J. Nutr. 99, 481-486, 2008.
52. K. Mochizuki, S. Takabe, and T. Goda: Changes of histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treatedwith a p44/42 MAPK inhibitor and glucocorticoid hormone. Biochem. Biophys. Res. Commu. 371, 324-327, 2008.
53. T. Morimoto, N. Obara, I. Yoshida, K. Tanaka, and T. Kan: Copper-catalyzed enantioselective conjugate addition of diethylzinc using axiallychiral aminoethyloxy-phosphine ligands. Tetrahedron Lett. 48, 3093-3095, 2007.
54. A. Morita, Y. Iwasaki, K. Kobata, H. Yokogoshi, and T. Watanabe: Newly synthesized oleylgingerol and oleylshogaol activate TRPV1 ionchannels. Biosci. Biotechnol. Biochem. 71, 2304-2307, 2007.
55. H. Morita, S. Kondo, S. Oguro, H. Noguchi, S. Sugio, I. Abe, and T. Kohno; Structural insight into chain-length control and product specificity of
pentaketide chromone synthase from Aloe arborescens. Chem. Biol. 14, 1-11, 2007.
56. K. Murakami, S. Sasaki, Y. Takahash,i K. Uenishi, M. Yamasaki, H. Hayabuchi, T. Goda, J. Oka, K. Baba, K. Ohki, T. Kohri, K. Muramatsu, and M.
Furuki: Hardness of the habitual diet in relation to body mass index and waist circumference in free-living Japanese women aged 18-22 years.
Am. J. Clin. Nutr. 86, 206-213, 2007.
57. M. Ogata, T. Murata, K. Murakami, T. Suzuki, K. I.P.J. Hidari, Y. Suzuki, and T. Usui: Chemoenzaymatic synthesis of artificial glycopolypeptides
containing multivalent sialyloligosaccharides with a γ-polyglutamic acid backbone and their effect on inhibition of infection by influenza viruses.
Bioorg. Med. Chem. 15, 1383-1393, 2007.
58. K. Ogawa, H. Sakakibara, R. Iwata, T. Ishii, T. Sato, T. Goda, K. Shimoi, and S. Kumazawa: Anthocyanin composition and antioxidant activity of
the crowberry (Empetrum nigrum) and other berries. J. Agric. Food Chem. 56, 4457-4462 ,2008.
59. M. Ohsumi, X. Shi, T. Tuchiya, H. Tujioka, S. Lyou, K. Hayase, and H. Yokogoshi: The role of growth hormone and amino acids on brain
protein synthesis in aged rats given proteins of different quantity and quality. Amino Acids, 32, 247-253, 2007.
60. T. Oki, A. Kageyama, Y. Takagi, S. Uchida, and S. Yamada: Comparative evaluation of central muscarinic receptor binding activity by
oxybutynin, tolterodine and darifenacin used to treat overactive bladder. J. Urol. 177, 766-770, 2007.
61. T. Okura, N. Komiyama, Y. Morita, M. Kimura, Y. Deguchi, and S. Yamada: Comparative measurement of spinal CSF microdialysate
concentrations and concomitant antinociception of morphine and morphine-6β-glucuronide in rats. Life Sci. 80, 1319-1326, 2007.
62. M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, and M. Miwa: Constitutive androstane receptor and peroxisome proliferator-activatedreceptor a are activated in liver of male rats fed a high-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 isenhanced. Drug Metab. Dispos. 36, 294-302, 2008.
63. M. Osabe, J. Sugatani, A. Takemura, Y. Yamazaki, A. Ikari, N. Kitamura, M. Negishi, and M. Miwa: Expression of CAR in SW480 and HepG2
cells during G1 is associated with cell proliferation. Biochem. Biophys. Res. Commun. 369, 1027-1033, 2008.
64. T. Oya-Ito, H. Naitou, S. Masuda, N. Kinae, and N. Ohashi: Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic
condition. Mol. Nutr. Food Res. 52, 360-369, 2008.
65. J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, K. Hatano, D.
Terunuma, and K. Matsuoka: Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase
inhibitors. Bioorg. Med. Chem. Lett. 17, 717-721, 2007.
66. T. Sakata, R. Furuya, T. Shimazu, M. Odamaki, S. Ohkawa, and H. Kumagai: Coenzyme Q10 administration suppresses both oxidative andantioxidative markers in hemodialysis patients. Blood Purificat. 26, 371-378, 2008.
67. T. Sawa, M. Mounawar, M. Tatemichi, I. Gilibert, T. Katoh, and H. Ohshima: Increased risk of gastric cancer in Japanese subjects is associatedwith microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. Cancer Lett. 269, 78-84,
2008.
68. S. Satoh, T. Toyo'oka, T. Fukushima, and S. Inagaki: Simultaneous determination of a-lipoic acid and its reduced form by high-performanceliquid chromatography with fluorescence detection. J. Chromatogr. B 854, 109-115, 2007.
69. K. Sato, K. Ikeda, T. Suzuki, S. Aoyama, N. Maki, Y. Suzuki, and M. Sato: Synthesis of 4-O-[3-(aryl)prop-2-ynyl]-Neu5Ac2en and its
4-epi-analogs modified at C-4 by Sonogashira coupling reaction. Tetrahedron, 63, 7571-7581, 2007.
70. T. Sawada, T. Hashimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishida, and M. Kiso: Influenza viral hemagglutinin complicated shapeis advantageous to its binding affinity for sialosaccharide receptor. Biochem. Biopohys. Res. Commun. 355, 6-9, 2007.
71. M. Shimizu, M. Goto, M. Hanai, T. Shimizu, N. Izawa, H. Kanamoto, K.-I. Tomizawa, A. Yokota, and H. Kobayashi: Selectable tolerance toherbicides by mutated acetolactate synthase genes integrated into the chloroplast genome of tobacco. Plant Physiol. 147, 1976-1983, 2008.
72. T. Sueyoshi, R. Moore, J. Sugatani Y. Matsumura, and M. Negishi: PPP1R16A, the membrane subunit of protein phosphatase 1b, signals nuclear
translocation of the nuclear receptor CAR. Mol. Pharmacol. 73, 1113-1121, 2008.
73. J. Sugatani, K. Mizushima, M. Osabe, K. Yamakawa, S. Kakizaki, H. Takagi, M. Mori, A. Ikari, and M. Miwa: Transcriptional regulation of human
UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. Naunyn
Schmiedebergs Arch. Pharmacol. 377, 597-605, 2008.
74. M. Suzuki, T. Oki, T. Sugiyama, K. Umegaki, S. Uchida, and S. Yamada: Muscarinic and alpha 1-adrenergic receptor binding characteristics ofsaw palmetto extract in rat lower urinary tract. Urology, 69, 1216-1220, 2007.
75. T. Suzuki, K. Mochizuki, and T. Goda: Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in inductionof the gene in the transition from the crypt to villus in the small intestine of rats. Biochem. Biophys. Res. Commu. 369, 788-793, 2008.

76. T. Suzuki, Y. Ishigami, N. Okada, A. Kaneko, R. Fukutomi, and M. Isemura: Differentiation-associated alteration in gene expression of importinsand exportins in human leukemia HL-60 cells. Biomed. Res. 29, 141-145, 2008.
77. S. Takabe, K. Mochizuki, and T. Goda: De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5
gene expression in Caco-2 cells. Arch. Biochem. Biophys. 475, 1-6, 2008.
78. T. Takahashi, K. Murakami, M. Nagakura, H. Kishita, S. Watanabe, K. Honke, K. Ogura, T. Tai, K. Kawasaki, D. Miyamoto, K.I.P.J. Hidari, C.-T.
Guo, Y. Suzuki, and T. Suzuki: Sulfatide is required for efficient replication of influenza A virus. J. Virol. 82, 5940-5950, 2008.
79. T. Takahashi, Y. Moriyama, A. Ikari, J. Sugatani, T. Suzuki, and M. Miwa: Surface localization of the nuclear receptor CAR in influenza A
virus-infected cells. Biochem. Biophys. Res. Commun. 368, 550-555, 2008.
80. A. Takeda, S. Kanno, N. Sakurada, M. Ando and N. Oku: Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar
concentrations of zinc. J. Neurosci. Res. 86, 2906-2911, 2008.
81. A. Takeda, S. Fuke, A. Minami, and N. Oku: Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate
receptor-mediated calcium release. J. Neurosci. Res. 85, 1310-1317, 2007.
82. A. Takeda, S. Fuke, W. Tsutsumi, and N. Oku: Negative modulation of presynaptic activity by zinc released from Schaffer collaterals. J. Neurosci.
Res. 85, 3666-3672, 2007.
83. A. Takeda, K. Yamada, H. Tamano, S. Fuke, M. Kawamura, and N. Oku: Hippocampal calcium dyshomeostasis and long-term potentiation in
2-week zinc deficiency. Neurochem. Int. 52, 241-246, 2008.
84. A. Takeda, A. Minami, N. Sakurada, S. Nakajima, and N. Oku: Response of hippocampal mossy fiber zinc to excessive glutamate release.
Neurochem. Int. 50, 322-327, 2007.
85. A. Takeda, H. Tamano, F. Kan, T. Hanajima, K. Yamada, and N. Oku: Enhancement of social isolation-induced aggressive behavior of young
mice by zinc deficiency. Life Sci. 82, 909-914, 2008.
86. T. Tanikawa, K. Kurohane, and Y. Imai: Production and characterization of IgA monoclonal antibody against ovalbumin. Hybridoma, 26, 328-332,
2007.
87. H. Tazawa, M. Tatemichi, T. Sawa, I. Gilibert, N. Ma, Y. Hiraku, L.A. Donehower, H. Ohgaki, S. Kawanishi, and H. Ohshima: Oxidative andnitrative stress caused by subcutaneous implantation of a foreign body accelerate sarcoma development in Trp53+/- mice. Carcinogenesis, 28,
191-198, 2007.
88. D. J. Tindal, J. C. Dyason, R. J. Thomson, T. Suzuki, H. Ueyama, Y. Kuwahara, N. Maki, Y. Suzuki, and M.V. Itzstein: Synthesis and evaluation of
4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity.
Bioorg . Med. Chem. Lett. 17, 1655-1658, 2007.
89. K. Tujioka, X. Shi, M. Ohsumi, T. Tuchiya, K. Hayase, T. Uchida, S. Ikeda, A. Morishita, and H. Yokogoshi: Effect of quantity and quality of dietary
protein on choline acetyltransferase and nerve growth factor, and their mRNAs in the cerebral cortex and hippocampus of rats. Amino Acids
36(1), 13-19, 2009.
90. S. Uchida, Y. Kato, K. Hirano, Y. Kagawa, and S. Yamada: Brain neurotransmitter receptor-binding characteristics in rats after oral administrationof haloperidol, risperidone and olanzapine. Life Sci. 80, 1635-1640, 2007.
91. S. Uchida, S. Kurosawa, T. Fujino (Oki), Y. Kato, M. Nanri, K. Yoshida, and S. Yamada: Binding activities by propiverine and its N-oxide
metabolites of voltage-dependent L-type calcium channel antagonist receptors in the rat bladder and brain. Life Sci. 80, 2454-2460, 2007.
92. Y. Uekusa, M. Kamihira, and T. Nakayama: Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR
spectroscopy. J. Agric. Food Chem. 55, 9986-9992, 2007.
93. T. Urakami, S. Akai, Y. Katayama, N. Harada, H. Tsukada, and N. Oku: Novel amphiphilic probes for [18F]-radiolabeling preformed liposomes
and determination of liposomal trafficking by positron emission tomography. J. Med. Chem. 50, 6454-6457, 2007.
94. K. Wanibuchi, P. Zhang, T. Abe, H. Morita, T. Kohno, G. Chen, H. Noguchi, and I. Abe: An acridone-producing novel multifunctional type III
polyketide synthase from Huperzia serrata. FEBS J. 274, 1073-1082, 2007.
95. A. Yamada, K. Hatano, T. Koyama, K. Matsuoka, N. Takahashi, K. I.P.J. Hidari, T. Suzuki, Y. Suzuki, and D. Terunuma: Lactotriaose-containing
carbosilane dendrimers: Syntheses and lectin-binding activities. Bioorg. Med. Chem. 15, 1606-1614, 2007.
96. K. Yamada, R. Furuya, T. Takita, Y. Maruyama, Y. Yamaguchi, S. Ohkawa, and H. Kumagai: Simplified nutritional screening tools for maintenancehemodialysis patients. Am. J. Clin. Nutr. 87, 106-113, 2008.
97. S. Yamada, C. Takeuchi, L. Oyunzul, and Y. Ito: Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet obstruction.
Eur. Uroll. 55, 482-489, 2009.
98. T. Yamada, T. Terashima, R. Kawano, R. Furuno, T. Okubo, L.R. Juneja, and H. Yokogoshi: Theanine, γ-glutamylethylamide, a unique amino acidin tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino Acids, 36(1), 21-27, 2009.
99. S. Yingsakmongkon, D. Miyamoto, N. Sriwilaijaroen, K. Fujita, K. Matsumoto, W. Jampangern, H. Hiramatsu, C.-T.Guo, T. Sawada, T. Takahashi,
K. I.P.J. Hidari, T. Suzuki, M. Ito, Y. Ito, and Y. Suzuki: In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of Japaneseplum. Biol. Pharm. Bull. 31, 511-515, 2008.
100. S. Yonezawa, T. Asai, and N. Oku: Effective tumor regression by antineovascular therapy in hypovascular orthotopic pancreatic tumor model. J.
Control. Release, 118, 303-309, 2007.

88

89

事業推進担当者・若手研究者の研究業績（原著論文）

平成20年度（2008−2009年）

事業推進担当者・若手研究者の研究業績（原著論文）

1. K. Abe, N. Okada, H. Tanabe, R. Fukutomi, K. Yasui, M. Isemura, N. Kinae: Effects of chronic ingestion of catechin-rich green tea on hepatic
gene expression of gluconeogenic enzymes in rats. Biomed. Res. 30, 25-29, 2009.
2. A. Ahmad, I. Kaji, Y. Murakami, N. Funato, T. Ogawa, M. Shimizu, Y. Niwa, H. Kobayashi: Transformation of Arabidopsis with plant-derived
DNA sequences necessary for selecting transformants and driving an objective gene. Biosci. Biotechnol. Biochem. 73, 936-938, 2009.
3. M.-R. Ahn, K. Kunimasa, S. Kumazawa, T. Nakayama, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, T. Ohta: Correlation between antiangiogenic
activity and antioxidant activity of various components from propolis. Mol. Nutr. Food Res. 53, 643-651 ,2009.
4. T. Asai, S. Miyazawa, N. Maeda, K. Hatanaka, Y. Katanasaka, K. Shimizu, S. Shuto, N. Oku: Antineovascular therapy with angiogenic
vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC. Cancer Sci. 99, 1029-1033, 2008.
5. T. Asai, Y. Suzuki, S. Matsushita, S. Yonezawa, J. Yokota, Y. Katanasaka, T. Ishida, T. Dewa, H. Kiwada, M. Nango, N. Oku: Disappearance of theangiogenic potential of endothelial cells caused by Argonaute2 knockdown. Biochem. Biophys. Res. Commun. 368, 243-248, 2008.
6. M.-J. Bae, T. Ishii, K. Minoda, Y. Kawada, T. Ichikawa, T. Mori, M. Kamihira, T. Nakayama: Albumin stabilizes (-)-epigallocatechin gallate in humanserum: binding capacity and antioxidant property. Mol. Nutr. Food Res. 53, 709-715 ,2009.
7. R. Eguchi, H. Naitou, K. Kunimasa, R. Ayuzawa, Y. Fujimori, N. Ohashi, K. Kaji, T. Ohta: Proteomic analysis of hypoxia-induced tube breakdown
of an in vitro capillary model composed of HUVECs: potential role of p38-regulated reduction of HSP27. Proteomics, 8, 2897-2906, 2008.
8. S. Fujimoto, K. Mochizuki, M. Shimada, Y. Murayama, T. Goda: Variations in gene expression of inflammatory cytokines in leukocyte-derived
cells of high-fat-diet-induced insulin-resistant rats. Biosci. Biotech. Biochem. 72, 2572-2579, 2008.
9. N. Fukaya, K. Mochizuki, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of
inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutr. 21, 1054, 2008.
10. T. Furuta, M. Mochizuki, M. Ito, T. Takahashi, T. Suzuki, T. Kan: Versatile synthesis of head group functionalized phospholipids via oxime bondformation. Org. Lett. 10, 4847-4850, 2008.
11. S. Goto, N. Okada, A. Kaneko, M. Isemura: Different effects of all-trans-retinoic acid on phorbol ester-stimulated andphytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells. Cell Struct. Funct. 33, 13-19, 2008.
12. K. Hata, K. Koseki, K. Yamaguchi, S. Moriya, Y. Suzuki, S. Yingsakmongkon, G. Hirai, M. Sodeoka, M. von Itzstein, T. Miyagi: Limited inhibitory
effects of oseltamivir and zanamivir on human sialidases. Antimicrob. Agents Chemother. 52, 3484-3491, 2008.
13. T. Hayashi, M. Miyake, T. Fukui, N. Sugaya, T. Daimon, S. Itoh, T. Oku, T. Tsuji, S. Toyoshima, Y. Imai: Exclusion of actin-binding protein
p57/coronin-1 from bacteria- containing phagosomes in macrophages infected with Legionella. Biol. Pharm. Bull. 31, 861-865, 2008.
14. T. Hibino, M. Yuzurihara, K. Terawaki, H. Kanno, Y. Kasa, A. Takeda: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet
aggregation in guinea-pig whole blood. J. Pharmacol. Sci. 108, 89-94, 2008.
15. T. Hibino, M. Yuzurihara, H. Kanno, Y. Kasa, A. Takeda: Goshuyuto, a Japanese traditional medicine, and aqueous extracts of Evodiae Fructus
constrict isolated rat aorta via adrenergic and/or serotonergic receptors. Biol. Pharm. Bull. 32, 237-241, 2009.
16. K. I.P.J. Hidari, N. Takahashi, M. Arihara, M. Nagaoka, K. Morita, T. Suzuki: Structure and anti-dengue virus activity of sulfated polysaccharide
from a marine alga. Biochem. Biophys. Res. Commun. 376, 91-95, 2008.
17. K. I.P.J. Hidari, T. Murata, K. Yoshida, Y. Takahashi, Y. Minamijima, Y. Miwa, S. Adachi, M. Ogata, T. Usui, Y. Suzuki, T. Suzuki: Chemoenzymaticsynthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection.
Glycobiology, 18, 779-788, 2008.
18. Y. Hirooka, M. Nitta, T. Furuta, T. Kan: Efficient synthesis of optically active gallocatechin-3-gallate derivatives via 6-endo cyclization. Synlett, 20,3234-3238, 2008.
19. K. Honma, K. Mochizuki, T. Goda: Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a highcarbohydrate/fat ratio diet. Nutr. 25, 40-44, 2009.
20. Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, K. J. Shea: Design of synthetic polymer nanoparticles that capture andneutralize toxic peptide. Small, 5, 1562-1568, 2009.
21. A. Ikari, C. Okude, H. Sawada, Y. Sasaki, Y. Yamazaki, J. Sugatani, M. Degawa, M. Miwa: Activation of a polyvalent cation-sensing receptor
decreases magnesium transport via claudin-16. Biochim. Biophys. Acta. 1778, 283-290, 2008.
22. A, Ikari, C. Okude, H. Sawada, T. Takahashi, J. Sugatani, M. Miwa: Down- regulation of TRPM6-mediated magnesium influx by cyclosporin A.
Naunyn Schmiedebergs Arch. Pharmacol. 377, 333-343, 2008.
23. A. Ikari, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa: TRPM6 expression and cell proliferation are up-regulated by phosphorylationof ERK1/2 in renal epithelial cells. Biochem. Biophys. Res. Commun. 369, 1129-1133, 2008.
24. A. Ikari, M. Ito, C. Okude, H. Sawada, H. Harada, M. Degawa, H. Sakai, T. Takahashi, J. Sugatani, M. Miwa: Claudin-16 is directly phosphorylated
by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway. J. Cell Physiol. 214, 221-229, 2008.
25. H. Imanaka, H. Koide, K. Shimizu, T. Asai, K. Shimizu, A. Ishikado, T. Makino, N. Oku: Chemoprevention of tumor metastasis by liposomal
beta-sitosterol intake. Biol. Pharm. Bull. 31, 400-404, 2008.
26. S. Inagaki, T. Noda, J.Z. Min, T. Toyo’oka: Ultraperformance liquid chromatography analysis of rat hairs for metabolomic research. Am. Lab.
On-Line Edition, June-July, 12-15, 2008.
27. M. Inai, T. Goto, T. Furuta, T. Wakimoto, T. Kan: Stereocontrolled total synthesis of (–)-myriocin. Tetrahedron-Asymmetry, 19, 2771-2773, 2008.

28. K. Inoue, S. Maruyama, H. Kabeya, N. Yamada, N. Ohashi, Y. Sato, M. Yukawa, T. Masuzawa, F. Kawamori, T. Kadosaka, N. Takada, H. Fujita, H.
Kawabata: Prevalence and genetic diversity of Bartonella species isolated from wild rodents in Japan. Appl. Environ. Microbiol. 74, 5086-5092,
2008.
29. T. Ishii, S. Ito, S. Kumazawa, T. Sakurai, S. Yamaguchi, T. Mori, T. Nakayama, K. Uchida: Site-specific modification of positively-charged surfaces
on human serum albumin by malondialdehyde. Biochem. Biophys. Res. Commun. 371, 28-32, 2008.
30. Y. Iwasaki, O. Saito, M. Tanabe, K. Inayoshi, K. Kobata, S. Uno, A. Morita, T. Watanabe: Monoacylglycerols activate capsaicin receptor, TRPV1.
Lipids, 43, 471-483, 2008.
31. K. Kajiya, S. Kumazawa, A. Naitou, T. Nakayama: Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green
tea polyphenol, incorporated into lipid bilayers. Magn. Reson. Chem. 46, 174-177, 2008.
32. H. Kako, S. Fukumoto, Y. Kobayashi, H. Yokogoshi: Effects of direct exposure of green odour components on dopamine release from rat brain
striatal slices and PC12 cells. Brain. Res. Bull. 75, 706-712, 2008.
33. M. Kamihira, H. Nakazawa, A. Kira, Y. Mizutani, M. Nakamura, T. Nakayama: Interaction of tea catechins with lipid bilayers investigated byquartz-crystal microbalance analysis. Biosci. Biotechnol. Biochem. 72, 1372-1375, 2008.
34. T. Kan, Y. Kawamoto, T. Asakawa, T. Furuta, T. Fukuyama: Synthetic studies on altemicidin: stereocontrolled construction of the coreframework. Org. Lett. 10, 169-171, 2008.
35. J. Kashimura, Y. Nagai, T. Goda: Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of α-glucosylsaccharides inthe small intestine. J. Agr. Food Chem. 56, 5892-5895, 2008.
36. Y. Katanasaka, T. Ida, T. Asai, K. Shimizu, F. Koizumi, N. Maeda, K. Baba, N. Oku: Antiangiogenic cancer therapy using tumor
vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett. 270,260-268, 2008.
37. Y. Katanasaka, T. Ida, T. Asai, N. Maeda, N. Oku: Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes. Int. J. Pharm.
360, 219-224, 2008.
38. Y. Kato, S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Sakaki, S. Yamada, M. Degawa: Hepatic UDP-glucuronosyltransferases responsible for
glucuronidation of thyroxine in humans. Drug Metab. Dispos. 36, 51-55, 2008.
39. A. Kato, T. Takita, M. Furuhashi, Y. Maruyama, H. Kumagai, A. Hishida: Blood monocyte count is a predictor of total and cardiovascularmortality in hemodialysis patients. Nephron Clin. Pract. 110, 235-243, 2008.
40. F. Kawamori, M. Hiroi, T. Harada, K. Ohata, K. Sugiyama, T. Masuda, N. Ohashi: Molecular typing of Japanese Escherichia coli O157:H7 isolates
from clinical specimens by multilocus variable-number tandem repeat analysis and PFGE. J. Med. Microbiol. 57, 58-63, 2008.
41. Y.Kita, T. Toma, T. Kan, T.Fukuyama: Synthetic studies on (+)-manzamine A: Stereo-selective synthesis of the tetracyclic core framework. Org.
Lett. 10, 3251-3253, 2008.
42. Y. Kitamura, S. Yoshikawa, T. Furuta, T. Kan: One-pot synthesis of carbazole via tandem Suzuki-Miyaura and amination reaction. Synlett, 3,
377-380, 2008.
43. K. Kobata, H. Tate, Y. Iwasaki Y, Y. Tanaka, K. Ohtsu, S. Yazawa, T. Watanabe: Isolation of coniferyl esters from Capsicum baccatum L., andtheir enzymatic preparation and agonist activity for TRPV1. Phytochemistry, 69, 1179-1184, 2008.
44. H. Koide, T. Asai, K. Hatanaka, T. Urakami, T. Ishii, E. Kenjo, M. Nishihara, M. Yokoyama, T. Ishida, H. Kiwada, N. Oku: Particle size-dependent
triggering of accelerated blood clearance phenomenon. Int. J. Pharm. 362, 197-200, 2008.
45. Y. Koizumi, H. Kobayashi, T. Wakimoto, T. Furuta, T. Fukuyama, T. Kan: Total synthesis of (–)-serotobenine. J. Am. Chem. Soc. 130,
16854-16855, 2008.
46. Y. Koizumi, S. Suzuki, K. Takeda, K. Murahashi, M. Horikawa, K. Katagiri, H. Masu, I. Azumaya, S. Fujii, T. Furuta, K. Tanaka, T. Kan: Synthesis andcharacteristic stereostructure of a biphenanthryl ether. Tetrahedron-Asymmetry, 19, 1407-1410, 2008.
47. M. Kojima, M. Sekimoto, M. Degawa: A novel gender-related difference in the constitutive expression of hepatic cytochrome P4501A
subfamily enzymes in Meishan pigs. Biochem. Pharmacol. 75, 1076-1082, 2008.
48. S. Lyou, S. Kawano, T. Yamada, S. Okuyama, T. Terashima, K. Hayase, H. Yokogoshi: Role of estrogen receptors and aromatase on brain
protein synthesis rates in ovariectmized female rats fed genistein. Nutr. Neurosci. 11(4), 155-160, 2008.
49. S. Maruyama, H. Tsukada, S. Nishiyama, T. Kakiuchi, D. Fukumoto, N. Oku, S. Yamada: In vivo quantitative autoradiographic analysis of brain
muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. J. Pharmacol. Exp. Ther. 325, 774-781, 2008.
50. T. Masuzawa, I. G. Kharitonenkov, Y. Okamoto, T. Fukui, N. Ohashi: Prevalence of anaplasma phagocytophilum and its coinfection with
Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species. J. Med.
Microbiol. 57, 986-991, 2008.
51. E. J. Mitacek, K. D. Brunnemann, M. Suttajit, L. S. Caplan, C. E. Gagna, K. Bhothisuwan, S. Siriamornpun, C. F. Hummel, H. Ohshima, R. Roy, N.
Martin: Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, andnitrosodimethylamine. Nutr. Cancer, 60, 196-203, 2008.
52. D. Miyamoto, S. Hasegawa, N. Sriwilaijaroen, S. Yingsakmongkon, T. Suzuki, K. I.P.J. Hidari, T. Takahashi, C.-T. Guo, Y. Sakano, Y. Suzuki:
Clarithromycin inhibits progeny virus production from human influenza virus – Infected host cells. Biol. Pharm. Bull. 31, 217-222, 2008.
53. N. Miyoshi, E. Watanabe, T. Osawa, M. Okuhira, Y. Murata, H. Ohshima, Y. Nakamura: ATP depletion alters the mode of cell death induced
by benzyl isothiocyanate. Biochim. Biophys. Acta. 1782, 566-573, 2008.
54. K. Mochizuki, S. Takabe, T. Goda: Changes of histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated witha p44/42 MAPK inhibitor and glucocorticoid hormone. Biochem. Biophys. Res. Commu. 371, 324-327, 2008

9091

平成20年度には拠点を形成する５専攻全体で258報の英文学術論文（IFの合計：667.233）を発表した。
（以下は事業推進担当者および若手研究者が発表した主な原著論文）

事業推進担当者・若手研究者の研究業績（原著論文）

55. K. Mochizuki, H. Kawai, H. Mochizuki, M. Shimada, S. Takase, T. Goda: Fatty acids in component of milk enhance the expression of thecAMP-response-element- binding-protein-binding-protein (CBP)/p300 gene in developing rats. Br. J. Nutr. 99, 481-486, 2008.
56. T. Mori, T. Ishii, T. Tanaka, D. Mizuno, R. Yamaji, S. Kumazawa, T. Nakayama, M. Akagawa: Covalent modification of proteins by green tea
polyphenol (-)-epigallocatechin-3-gallate through autoxidation. Free Radic. Biol. Med. 45, 1384-1394, 2008.
57. K. Motoyama, Y. Nakai, T. Miyashita, Y. Fukui, M. Morita, K. Sanmiya, H. Sakakibara, I. Matsumoto, K. Abe, T. Yakabe, N. Yajima, K. Shimoi:
Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice. Physiol. Genomics, 37,
79-87, 2009.

事業推進担当者・若手研究者の研究業績（原著論文）

78. C. Sugimoto, E. E. Nakayama, T. Shioda, F. Villinger, A. A. Ansari, N. Yamamoto, Y. Suzuki, Y. Nagai, K. Mori: Impact of glycosylation on
antigenicity of Simian immunodecficiency virus SIV239: Induction of rapid V1/V2 specific non-neutralizing antibody and delayed neutralizing
antibody following infection with an attenuated deglycosylated mutant. J. Gen. Virol. 89, 554-566, 2008.
79. O.Suptawiwat, A. Kongchanagul, W.Chan-It, A. Thitithanyanont, W. Wiriyarat, K. Chaichuen, T. Songserm, Y. Suzuki, P. Puthavathana, P.
Auewarakul: A simple screening assay for receptor switching of avian influenza viruses. J. Clinical Virol. 42, 186-189, 2008.
80. T. Suzuki, K. Mochizuki, T. Goda: Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of
the gene in the transition from the crypt to villus in the small intestine of rats. Biochem. Biophys. Res. Commu. 369, 788-793, 2008.

58. K. Murakami, S. Sasaki, Y. Takahashi , K. Uenishi, M. Yamasaki, H. Hayabuchi, T.Goda, J. Oka, K. Baba, K. Ohki, T. Kohri, R. Watanabe, Y.
Sugiyama: Misreporting of dietary energy, protein, potassium, and sodium in relation to body mass index in young Japanese women. Eur. J. Clin.
Nutr. 62, 111-118, 2008.

81. S. Takabe, K. Mochizuki, T. Goda: De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene
expression in Caco-2 cells. Arch. Biochem. Biophys. 475, 1-6, 2008.
82. T. Takahashi, K. Murakami, M. Nagakura, H. Kishita, S. Watanabe, K. Honke, K. Ogura, T. Tai, K. Kawasaki, D. Miyamoto, K. I.P.J. Hidari, C.T.

59. Y. Murayama, K. Mochizuki, M. Shimada, Y. Matsuoka, K. Shibata, T. Goda: Effects of wheat albumin consumption on expression of genes
related to lipogenesis and insulin sensitivity in adipose tissues of rats. J. Agr. Food Chem. 57, 1606-1611, 2008.
60. M. Nakayama, N. Yoshimura: Japanese EFL Learners’ Skills improvement and the length of study abroad programs. Ars Linguistica, 15,
54-64, 2008.

Guo, Y. Suzuki, T. Suzuki: Sulfatide is required for efficient replication of influenza A virus. J. Virol. 82, 5940-5950, 2008.
83. T. Takahashi, Y. Moriyama, A. Ikari, J. Sugatani, T. Suzuki, M. Miwa: Surface localization of the nuclear receptor CAR in influenza A
virus-infected cells. Biochem. Biophys. Res. Commun. 368, 550-555, 2008.
84. A. Takeda, H. Tamano, H. Itoh, N. Oku: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem. Int.

61. K. Ogawa, H. Sakakibara, R. Iwata, T. Ishii, T. Sato, T. Goda, K. Shimoi, S. Kumazawa: Anthocyanin composition and antioxidant activity of the
Crowberry (Empetrum nigrum) and other berries. J Agric Food Chem. 56, 4457-4462, 2008.
62. H. Oka, T. Onaga, T. Koyama, C.T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, K. Matsuoka: Sialylα(2-3) lactose clusters using
carbosilane dendorimer core scaffolds as influenza hemagglutinin blockers. Bioor. Med. Chem. Lett. 18, 4405-4408, 2008.
63. N. Okada, Y. Ishigami, T. Suzuki, A. Kaneko, K. Yasui, R. Fukutomi, M. Isemura: Importins and exportins in cellular differentiation. J. Cell. Mol.
Med. 12, 1863-1871, 2008.

53, 230-235, 2008.
85. A. Takeda, H. Itoh, A. Nagayoshi, N. Oku: Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet.
Epilepsy Res. 83, 73-80, 2009.
86. A. Takeda, H. Tamano, F. Kan, T. Hanajima, K. Yamada, N. Oku: Enhancement of social isolation-induced aggressive behavior of young mice byzinc deficiency. Life Sci. 82, 909-914, 2008.
87. A. Takeda, H. Itoh, K. Yamada, H. Tamano, N. Oku: Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on

64. T. Okura, T. Ozawa, Y. Ito, M. Kimura, Y. Kagawa, S. Yamada: Enhancement by grapefruit juice of morphine antinociception. Biol. Pharm. Bull.
31, 2338-2341, 2008.

behavior. BioMetals, 21, 545-552, 2008.
88. A. Takeda, K. Yamada, H. Tamano, S. Fuke, M. Kawamura, N. Oku: Hippocampal calcium dyshomeostasis and long-term potentiation in

65. M. Osabe, J. Sugatani, T. Fukuyama, S. Ikushiro, A. Ikari, M. Miwa: Constitutive androstane receptor and peroxisome proliferator-activatedreceptor a are activated in liver of male rats fed a high-fat and high-sucrose diet and the hepatic expression of UGT1A1 and UGT1A6 isenhanced. Drug Metab. Dispos. 36, 294-302, 2008.

2-week zinc deficiency. Neurochem. Int. 52, 241-246, 2008.
89. A. Takeda, S. Fuke, M. Ando, N. Oku: Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar
concentrations of zinc. Neurosci. 158, 585-591, 2009.

66. M. Osabe, J. Sugatani, A. Takemura, M. Kurosawa, Y. Yamazaki, A. Ikari, M. Miwa: Up-regulation of CAR expression through Elk-1 in HepG2and SW480 cells by serum starvation stress. FEBS Lett. 583, 885-889, 2009.
67. M. Osabe, J. Sugatani, A. Takemura, Y. Yamazaki, A. Ikari, N. Kitamura, M. Negishi, M. Miwa: Expression of CAR in SW480 and HepG2 cells
during G1 is associated with cell proliferation. Biochem. Biophys. Res. Commun. 369, 1027-1033, 2008.
68. T. Oya-Ito, H. Naitou, S. Masuda, N. Kinae, N. Ohashi: Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic

90. A. Takeda, S. Kanno, N. Sakurada, M. Ando, N. Oku: Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar
concentrations of zinc. J. Neurosci. Res. 86, 2906-2911, 2008.
91. T. Tanaka, A. Suzuki, S. Kuranuki, K. Mochizuki, K. Suruga, S. Takase, T. Goda: Higher expression of jejunal LPH gene in rats fed thehigh-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 innuclear proteins to its promoter regions. Life Sci. 83, 122-127, 2008.
92. Y.Tanaka, K.Mochizuki, N.Fukaya, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1β

condition. Mol. Nutr. Food Res. 52, 360-369, 2008.
69. T. Sakata, R. Furuya, T. Shimazu, M. Odamaki, S. Ohkawa, H. Kumagai.: Coenzyme Q10 administration suppresses both oxidative andantioxidative markers in hemodialysis patients. Blood Purif. 26, 371-378, 2008.
70. T. Sawa, M. Mounawar, M. Tatemichi, I. Gilibert, T. Katoh, H. Ohshima: Increased risk of gastric cancer in Japanese subjects is associated withmicrosatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. Cancer Lett. 269, 78-84, 2008.
71. T. Sawada, T. Hashimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishida, M. Kiso: Ab initio fragment molecular orbital studies ofinfluenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination. Glycoconjugate
J. 25, 805-815, 2008.

and TNF-α gene expression induced in rat peripheral leukocytes by intermittent sucrose loading. Br. J. Nutr. 21, 1054, 2008.
93. T. Taniguchi, T. Harada, T. Hayashi, T. Tanikawa, K. Kurohane, M. Miyake, Y. Imai: Elevated production of Legionella-specific immunoglobulin A
in A/J mice is accompanied by T-helper 1-type polarization. Immunol. Lett. 121, 123-126, 2008.
94. T. Tanikawa, T. Ishikawa, T. Maekawa, K. Kurohane, Y. Imai: Characterization of monoclonal immunoglobulin A and G against Shiga toxin
binding subunits produced by intranasal immunization. Scand. J. Immunol. 68, 414-422, 2008.
95. S. Uchida, K. Hirai, J. Hatanaka, J. Hanato, S. Yamada: Antinociceptive Effects of St. John’ s Wort, Harpagophytum Procumbens extract andgrape seed proanthocyanidins extract in mice. Biol. Pharm. Bull. 31, 240-245, 2008.

72. T. Shiba, T. Maruyama, K. Kurohane, Y. Iwasaki, T. Watanabe, Y. Imai: TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism incontact hypersensitivity. J. Neuroimmunol. 207, 66-74, 2009.

96. K. Umehara, K. Nemoto, K. Kimijima, A. Matsushita, E. Terada, O. Monthakantirat, W. De-Eknamkul, T. Miyase, T. Warashina, M. Degawa, H.
Noguchi: Estrogenic constituents of the heartwood of Dalbergia parviflora. Phytochemistry, 69, 546-552, 2008.

73. M. Shimada, K. Mochizuki, T. Goda: Dietary resistant starch reduces levels of GIP mRNA along the jejunum-ileum in both normal and type 2
diabetic rats. Biosci. Biotech. Biochem. 72, 2206-2209, 2008.

97. H. Yagi, N. Yasukawa, S.-Y. Yu, C.-T. Guo, N. Takahashi, T. Takahashi, W. Bukawa, T. Suzuki, K.-H. Khoo, Y. Suzuki, K. Kato: The expression of
sialylated high-antennary N-glyeans in edible bird’ s nest. Carbohydr. Res. 343, 1373-1377, 2008.

74. M. Shimizu, M. Goto, M. Hanai, T. Shimizu, N. Izawa, H. Kanamoto, KI. Tomizawa, A. Yokota, H. Kobayashi: Selectable tolerance to herbicides
by mutated acetolactate synthase genes integrated into the chloroplast genome of tobacco. Plant Physiol. 147, 1976-1983, 2008.
75. T. Sueyoshi, R. Moore, J. Sugatani, Y. Matsumura, M. Negishi: PPP1R16A, the membrane subunit of protein phosphatase 1b, signals nuclear
translocation of the nuclear receptor CAR. Mol. Pharmacol. 73, 1113-1121, 2008.

98. K. Yamada, R. Furuya, T. Takita, Y. Maruyama, Y. Yamaguchi, S. Ohkawa, H. Kumagai: Simplified nutritional screening tools for patients on
maintenance hemodialysis. Am. J. Clin. Nutr. 87, 106-113, 2008.
99. T. Yamada, T. Terashima, T. Okubo, L. R. Juneja, H. Yokogoshi: Effects of theanine, a unique amino acid in tea leaves, on memory in a rat

76. J. Sugatani, K. Mizushima, M. Osabe, K. Yamakawa, S. Kakizaki, H. Takagi, M. Mori, A. Ikari, M. Miwa: Transcriptional regulation of humanbehavioral test. Biosci. Biotechnol. Biochem. 72, 1356-1359, 2008.
100. S. Yingsakmongkon, D. Miyamoto, N. Sriwilaijaroen, K. Fujita, K. Matsumoto, W. Jampangern, H. Hiramatsu, C.-T. Guo, T. Sawada, T. Tskahashi,

UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. Naunyn

K. I.P.J. Hidari, T. Suzuki, M. Ito, Y. Ito, Y. Suzuki: In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of JapaneseSchmiedebergs Arch. Pharmacol. 377, 597-605, 2008.

plum (Prunus mume Sieb. et Zucc). Biol. Pharm. Bull. 31, 511-515, 2008.

77. J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, T. Takahashi, A. Ikari, M. Miwa: Comparison of enzymatically synthesized inulin,
resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high sucrose (cafeteria) diet. Eur. J.
Nutr. 47, 192-200, 2008.

92

93

事業推進担当者・若手研究者の研究業績（原著論文）

平成21年度（2009−2010年）

事業推進担当者・若手研究者の研究業績（原著論文）

1. M.-R. Ahn, K. Kunimasa, S. Kumazawa, T. Nakayama, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, T. Ohta: Correlation between antiangiogenic
activity and antioxidant activity of various components from propolis. Mol. Nutr. Food Res. 53, 643-651, 2009.
2. Y. Aihara, A. Yoshida, T. Furuta, T. Wakimoto, T. Akizawa, M. Konishi, T. Kan: Regioselective Synthesis of Methylated Epigallocatechin Gallate
via Nitrobenzenesulfonyl (Ns) Protecting Group. Bioorg. Med. Chem. Lett. 19, 4171-4174, 2009.
3. M.-J. Bae, T. Ishii, K. Minoda, Y. Kawada, T. Ichikawa, T. Mori, M. Kamihira, T. Nakayama: Albumin stabilizes (−)-epigallocatechin gallate inhuman serum: binding capacity and antioxidant property. Mol. Nutr. Food Res. 53 709-715, 2009.
4. N. Fukaya, K. Mochizuki, Y. Tanaka, T. Kumazawa, Z. Jiuxin, M. Fuchigami, T. Goda: The alpha-glucosidase inhibitor miglitol delays thedevelopment of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur. J. Pharmacol. 624, 51-57, 2009.
5. N. Fukaya, K. Mochizuki, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of
inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutr. 25, 657-667, 2009.
6. T. Furuta, H. Onuki, M. Mochizuki, M. Ito, M. Inai, T. Wakimoto, T. Kan: Solid Support Synthesis of Artificial Phospholipids. Synlett, 3373-3377,
2009.
7. T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan: Concise Synthesis of Chafurosides A and B. Org. Lett.
11. 2233-2236, 2009.
8. J. Hanato, K. Kuriyama, T. Mizumoto, K. Debari, J. Hatanaka, S. Onoue, S. Yamada: Liposomal formulations of glucagon-like peptide-1:
Improved bioavailability and anti-diabetic effect. Int. J. Pharm. 382, 111-116, 2009.
9. K. Hatanaka, T. Asai, H. Koide, E. Kenjo, T. Tsuzuku, N. Harada, H. Tsukada, N. Oku: Development of Double-Stranded siRNA Labeling Method
Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography. Bioconjugate Chem. 21, 756-763, 2010.
10. T. Hibino, M. Yuzurihara, Y. Kasa, A. Takeda: Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic andSerotonergic Receptors. J. Pharmacol. Sci. 111, 73-81, 2009.
11. K. I.P.J. Hidari, M. Ogata, T. Murata, S. Shimada, W. Kozaki, E. Y. Park, T. Suzuki, T. Usui: Chemoenzymatic synthesis of sialoglycopolypeptides
as glycomimetics to block infection by avian and human influenza viruses. Bioconjugate Chem. 20, 538-549, 2009.
12. K. I.P.J. Hidari, K. Oyama, G. Ito, M. Nakayama, M. Inai, S. Goto, Y. Kanai, K. Watanabe, K. Yoshida, T. Furuta, T. Kan, T. Suzuki: Identificationand characterization of flavonoids as sialyltransferase inhibitors. Biochem. Biophys. Res. Commun. 382, 609-613, 2009.
13. T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cellline HepG2 by the calcium channel blocker nicardipine. Cancer Sci. 101, 652-657, 2010.
14. Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, K.-J. Shea: Design of synthetic polymer nanoparticles that capture andneutralize a toxic peptide. Small, 5, 1562-1568, 2009.
15. A. Ikari , A. Sanada , C. Okude, H. Sawada , Y. Yamazaki , J. Sugatani, M. Miwa: Up-regularion of TRPM6 transcriptional activity by AP-1 inrenal epithelial cells. J. Cell. Physiol. 222(3), 481-487, 2010.
16. A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16
mediated by ERK-dependent phosphorylation. Biochim. Biophys. Acta 1798 (3), 415-421, 2010.
17. A. Ikari, K. Atomi, A. Takiguchi, Y. Yamazaki, M. Miwa, J. Sugatani: Epidermal growth factor increases claudin-4 expression mediated by Sp1elevation in MDCK cells. Biochem. Biophys. Res. Commun. 384(3), 306-310, 2009.
18. N. Ikegaya, T. Yoshida, T. Kohsaka, A. Suzuki, N. Kobayashi, T. Yamamoto, Y. Fujigaki, A. Hishida, H. Kumagai: Effects of relaxin on
development of mesangial proliferative nephritis. Ann. N. Y. Acad. Sci. 1160, 300-303, 2009.
19. Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal
Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commun. 392, 16-21, 2010.
20. T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea
catechins for human serum albumin: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol.
Nutr. Food Res. 54, 816-822, 2010.
21. T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free
Radical Res. 44, 403-409, 2010.
22. T. Ishii, T. Asai, T. Urakami, N. Oku: Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.
Brain Res. 1321, 164-168, 2010.
23. Y. Ito, L. Oyunzul, M. Seki, T. Oki-Fujino, M. Matsui, S. Yamada: Quantitative analysis of the loss of muscarinic receptors in various peripheral
tissues in M1-M5 single subtype knockout mice. Br. J. Pharmacol. 156, 1147-1153, 2009.
24. Y. Iwasaki, M. Tanabe, Y. Kayama, M. Abe, M. Kashio, K. Koizumi, Y. Okumura, Y. Morimitsu, M. Tominaga, Y. Ozawa, T. Watanabe: Miogadial
and miogatrial with a,b-unsaturated 1,4-dialdehyde moieties—Novel and potent TRPA1 agonists. Life Sci. 85, 60-69, 2009.
25. I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose
transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem. 22, 334-343,
2011.
26. H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: Beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation andthe suppression of genes related to insulin sensitivity induced by TNF-α. Nutr. 26, 1151-1156 ,2010.

27. M. Kashiwamura, K. Kurohane, T. Tanikawa, A. Deguchi, D. Miyamoto, Y. Imai: Shiga toxin kills epithelial cells isolated from distal but notproximal part of mouse colon. Biol. Pharm. Bull. 32, 1614–1617, 2009.
28. Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy withliposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer 127, 2685-2698 ,2010.
29. Y. Kato, K. Haraguchi, M. Kubota, M. Seto, T.Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease inserum thyroxine level by a TCDD-like PCB congener, 3,3',4,4',5-pentachlorobiphenyl, in mice. Drug Metab. Dispos. 38(1), 150-156, 2010.
30. M. Kato, N. Shoda, T. Yamamoto, R. Shiratori, T. Toyo'oka: Development of a silica-based double-network hydrogel for high-throughput
screening of encapsulated enzymes. Analyst, 134, 577-581, 2009.
31. M. Kato, T. Yamamoto, M. Sekimoto, M. Degawa, T. Toyo'oka: An easy cell-based microchip assay method for a CYP1A1-mediated drug
metabolism using adhesive HepG2 cells. J. Appl. Phys. 105, 1-4, 2009.
32. M. Kato, Y. Onda, M. Sekimoto, M. Degawa, T. Toyo'oka: A capillary electrochromatography-electron spray ionization-mass spectrometry
method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome. J. Chromatogr. A 1216,
8277-8282, 2009.
33. Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of
dopamine release from PC12 cells by the green odor compound hexanal. Cell. Mol. Neurobiol. accepted for publication, 2010.
34. H. Koide, T. Asai, K. Hatanaka, S. Akai, T. Ishii, E. Kenjo, T. Ishida, H. Kiwada, H. Tsukada, N. Oku: T cell-independent B cell response isresponsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. Int. J. Pharm. 392, 218-223, 2010.
35. K. Kunimasa, M.-R. Ahn, T. Kobayashi, R. Eguchi, S. Kumazawa, Y. Fujimori, T. Nakano, T. Nakayama, K. Kaji, T. Ohta: Brazilian propolis
suppresses angiogenesis by inducing apoptosis in tube-forming endothelial cells through inactivation of survival signal ERK1/2. Evid.-based
Complement Altern. Med. in press.
36. S. Kurosawa, S. Uchida Y. Ito, S. Yamada: Effect of ursodeoxycholic acid on the pharmacokinetics and midazolam and CYP3A activity in theliver and small intestine of rats. Xenobiotica, 39, 162-170, 2009.
37. P. Luecha, K. Umehara, T. Miyase, H. Noguchi: Antiestrogenic Constituents of the Thai Medicinal Plants Capparis flavicans and Vitex glabrata. J.
Nat. Prod. 72 (11), 1954-1959, 2009.
38. T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett. 192,
97-100, 2010.
39. S. Misaka, H. Sato, Y. Yamauchi, S. Onoue, S. Yamada: Novel dry powder formulation of Ovalbumin for development of COPD-like animalmodel: physicochemical characterization and biomarker profiling in rats. Eur. J. Pharm. Sci. 37, 469-476, 2009.
40. Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma IL-1b concentrations are closely associated withfasting blood glucose levels in healthy and preclinical middle-aged, non-overweight and overweight Japanese men. Metab. 59,
1465-1471 ,2010.
41. Y, Mizuuchi, S.-P. Shi, K. Wanibuchi, A. Kojima, H. Morita, H. Noguchi, I. Abe: Novel type III polyketide synthases from Aloe arborescens. FEBS J.
276, 2391-2401, 2009.
42. K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat
diet in mice. Mol. Nutr. Food Res. 54, 1-7, 2010.
43. K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the
α-glucosidase inhibitor miglitol. Metab. 59, 1442-1447, 2010.
44. K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated
galactose on glycosylated chain of S-I complex. Life Sci. 86, 524-531, 2010.
45. H. Morita, Y. Shimokawa, M. Tanio, R. Kato, H. Noguchi, S. Sugio, I. Abe: A structure-based mechanism for benzalacetone synthase from
Rheum palmatum. Proc. Natl. Acad. Sci. U.S.A. 107(2), 669-73, 2010.
46. K. Motoyama, Y. Nakai, T. Miyashita, Y. Fukui, M. Morita, K. Sanmiya, H. Sakakibara, I. Matsumoto, K. Abe, T. Yagabe, N. Yajima, K. Shimoi:
Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice. Physiol. Genomics, 37(2), 79-87, 2009.
47. Y. Murase, T. Asai, Y. Katanasaka, T. Sugiyama, K. Shimizu, N. Maeda, N. Oku: A novel DDS strategy, "dual-targeting", and its application for
antineovascular therapy. Cancer Lett. 287, 165-171, 2010.
48. Y. Murayama, K. Mochizuki, M. Shimada, Y. Matsuoka, K. Shibata, T. Goda: Effects of wheat albumin consumption on expression of genes
related to lipogenesis and insulin sensitivity in adipose tissues of rats. J. Agric. Food Chem. 57, 1606-1611, 2009.
49. Y. Murayama, K. Mochizuki, M. Shimada, S. Fujimoto, K. Nukui, K. Shibata, T. Goda: Dietary supplementation with a-amylase inhibitor wheat
albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose
tissue. J. Agric. Food Chem. 57, 9332-9338, 2009.
50. M. Ogata, K. I. P. J. Hidari, W. Kozaki, T. Murata, J. Hiratake, E. Y. Park, T. Suzuki, T. Usui: Molecular Design of Spacer-N-Linked
Sialoglycopolypeptide as Polymeric Inhibitors Against Influenza Virus Infection. Biomacromolecules, 10, 1894-1903, 2009.
51. H. Oka, T. Onaga, T. Koyama, C.-T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, K. Matsuoka: Syntheses and biological evaluations ofcarbosilane dendrimers uniformly functionalized with sialyl α2→3) lactose moieties as inhibitors for human influenza viruses. Bioorg. Med.
Chem. 17, 5465-5475, 2009.
52. S. Onoue, H. Sato, Y. Kawabata, T. Mizumoto, N. Hashimoto, S. Yamada: In vitro and in vivo characterization on amorphous solid dispersionof cyclosporine A for inhalation therapy. J. Controlled Release, 138, 16-23, 2009.

9495

平成21年度には拠点を形成する５専攻全体で298報の英文学術論文（IFの合計：795.832）を発表した。
（以下は事業推進担当者および若手研究者が発表した主な原著論文）

事業推進担当者・若手研究者の研究業績（原著論文）

53. M. Osabe, J. Sugatani, A. Takemura, M. Kurosawa, Y. Yamazaki, A. Ikari, M. Miwa: Up-regulation of CAR expression through Elk-1 in HepG2and SW480 cells by serum starvation stress. FEBS Lett. 583(5), 885-889, 2009.
54. Y. Osada, R. Miyauchi, T. Goda, N. Kasezawa, H. Horiike, M. Iida, S. Sasaki, K. Yamakawa-Kobayashi: Variations in the WNK1 gene modulates
the effect of dietary intake of sodium and potassium on blood pressure determination. J. Hum. Genet. 54, 474-478, 2009.
55. Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole)
sulfone. Synlett, 827-829, 2010.
56. H. Sakakibara, T. Ogawa, A. Koyabagi, S. Kobayashi, T. Goda, S. Kumazawa, H. Kobayashi, K. Shimoi: Distribution and excretion of bilberry
anthocyanines. J. Agric. Food Chem. 57(17), 7681-7686, 2009.
57. J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, T. Nakamura, K.
Hatano, D. Terunuma, K. Matsuoka: Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly
functionalized with thioglycoside-type sialic acid moieties. Bioorg. Med. Chem. 17, 5451-5464, 2009.
58. N. Sakurai, K. Mochizuki, H. Kameji, M. Shimada, T. Goda: (-)-Epigallocatechin gallate enhances the expression of gene related to insulin
sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutr. 25, 1047-1056, 2009.
59. Y. Seto, S. Onoue, S. Yamada: In vitro/In vivo phototoxic risk assessments of griseofulvin Based on photobiochemical and disposition behaviors.
Eur. J. Pharm. Sci. 38, 104-111, 2009.
60. S.-P. Shi, K. Wanibuchi, H. Morita, K. Endo, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone
scaffolds by plant type III polyketide synthase. Org. Lett. 10, 551-554, 2009.
61. S.-P. Shi, H. Morita, K. Wanibuchi, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel polyketide scaffolds by plant-specific type III
polyketide synthase. Tetrahedron Lett. 50, 2150-2153, 2009.
62. M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylationon the gene from the upper jejunum towards the ileum. J. Agric. Food Chem. 57, 8049-8055, 2009.
63. M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control ofphotosystem stoichiometry. Proc. Natl. Acad. Sci. U.S.A. 107, 10760-10764, 2010. “Research Highlights" Nature Chem. Biol. 6, 480, 2010.
64. K. Shimizu, M. Osada, K. Takemoto, Y. Yamamoto, T. Asai, N. Oku: Temperature-dependent transfer of amphotericin B from liposomal
membrane of AmBisome to fungal cell membrane. J. Controlled Release, 141, 208-215, 2010.
65. K. Shimizu, N.K. Shimizu, W. Hakamata, K. Unno, T. Asai, N. Oku: Preventive effect of green tea catechins on experimental tumor metastasis
in senescence-accelerated mice. Biol. Pharm. Bull. 33,117-121, 2010.
66. N. Sriwilaijaroen, P. Wilairat, H. Hiramatsu, T. Takahashi, T. Suzuki, M. Ito, Y. Ito, M. Tashiro, Y. Suzuki: Mechanisms of the action of
povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities. Virol. J. 06, 124, 2009.
67. J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2
cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell-cycle dependent expression. Drug Metab. Dispos. 38(1),177-186, 2010.
68. S. W. Suh, S. J. Won, A. M. Hamby, Y. Fan, C. T. Sheline, H. Tamano, A. Takeda, J. Liu: Decreased brain zinc availability reduces hippocampal
neurogenesis in mice and rats. J. Cereb. Blood Flow Metab. 29, 1579-1588, 2009.
69. K. Suzuki, J. Sakamoto, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, D. Terunuma, K. Matsuoka: Synthesis of sialic acid derivatives
having a C=C double bond substituted at the C-5 position and their glycopolymers. Bioorg. Biomed. Chem. Lett. 19, 5105-5108, 2009.
70. T. Suzuki, K. Mochizuki, T. Goda: Localized expression of genes related to carbohydrate and lipid absorption along the crypt-villus axis of rat
jejunum. Biochim. Biophys. Acta, 1790, 1624-1635, 2009.
71. H. Takahama, T. Minamino, H. Asanuma, M. Fujita, T. Asai, M. Wakeno, H. Sasaki, H. Kikuchi, K. Hashimoto, N. Oku, M. Asakura, J. Kim, S.
Takashima, K. Komamura, M. Sugimachi, N. Mochizuki, M. Kitakaze: Prolonged targeting of ischemic/reperfused myocardium by liposomal
adenosine augments cardioprotection in rats. J. Am. Coll. Cardiol. 53, 709-717, 2009.
72. T. Takahashi, A. Hashimoto, M. Maruyama, H. Ishida, M. Kiso, Y. Kawaoka, Y. Suzuki, T. Suzuki: Identification of amino acid residues of influenza
A virus H3 HA contributing to the recognition of molecular species of sialic acid. FEBS Lett. 583, 3171-3174, 2009.
73. A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc Differentially Acts on Components of Long-term Potentiation at
Hippocampal CA1 Synapse. Brain Res. 1323, 59-64, 2010.
74. A. Takeda, H. Itoh, A. Nagayoshi, N. Oku: Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet.
Epilepsy Res. 83, 73-80, 2009.
75. A. Takeda, M. Ando, S. Kanno, N. Oku: Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent
mossy fiber long-term potentiation. Neurotoxicol. 30, 712-717, 2009.
76. A. Takeda, N. Sakurada, M. Ando, S. Kanno, N. Oku: Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus.
Neurochem. Int. 55, 376-382, 2009.
77. A. Takeda, S. Fuke, M. Ando, N. Oku: Positive Modulation of Long-term Potentiation at Hippocampal CA1 Synapses by Low Micromolar
Concentrations of Zinc. Neurosci. 158, 585-591, 2009.

96

事業推進担当者・若手研究者の研究業績（原著論文）

78. Y. Taki, Y. Yamazaki, F. Shimura, S. Yamada, K. Umegaki: Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA
expression by bilobalide in rats. J. Pharmacol. Sci. 109, 459-462, 2009.
79. H. Tamano, F. Kan, M. Kawamura, N. Oku, A. Takeda: Behavior in the forced swim test and neurochemical changes in the hippocampus inyoung rats after 2-week zinc deprivation. Neurochem. Int. 55, 536-541, 2009.
80. Y. Tanaka, K. Mochizuki, N. Fukaya, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1β
and TNF-α gene expression induced in rat peripheral leukocytes by intermittent sucrose loading. Br. J. Nutr. 102, 221-225, 2009.
81. Y. Tanaka, M. Hosokawa, K. Otsu, T. Watanabe, S. Yazawa: Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, inCapsicum cultivars. J. Agric. Food Chem. 57, 5407-5412, 2009.
82. Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protectivefunction in experimental colitis in mice. J. Biol. Chem. 285(9). 6750-6760, 2010.
83. S. Tomono, N. Miyoshi, K. Sato, Y. Ohba, H. Ohshima: Formation of cholesterol ozonolysis products through an ozone-free mechanism
mediated by the myeloperoxidase-H2O2-chloride system. Biochem. Biophys. Res. Commun. 383(2), 222-227, 2009.
84. K. Umehara, K. Nemoto, A. Matsushita, E. Terada, O. Monthakantirat, W. De-Eknamkul, T. Miyase, T. Warashina, M. Degawa, H. Noguchi:
Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parWiflora and their effects on estrogenic-responsive human breast
cancer cells. J. Nat. Prod. 72, 2163-2168, 2009.
85. T. Urakami, K. Sakai, T. Asai, D. Fukumoto, H. Tsukada, N. Oku: Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor
imaging with positron emission tomography. Nucl. Med. Biol. 36, 295-303, 2009.
86. T. Urakami, T. Kawaguchi, S. Akai, K. Hatanaka, H. Koide, K. Shimizu, T. Asai, D. Fukumoto, N. Harada, H. Tsukada, N. Oku: In vivo distributionof liposome-encapsulated hemoglobin determined by positron emission tomography. Artif. Organs. 33, 164-168, 2009.
87. T. Wakimoto, M. Nitta, K. Kasahara, T. Chiba, Y. Ye, K. Tsuji, T. Kan, H. Nukaya, M. Ishiguro, M. Koike, Y. Yokoo, Y. Suwa: Structure-activity
relationship study on a 1 adrenergic receptor antagonists from beer. Bioorg. Med. Chem. Lett. 19, 5905-5908, 2009.
88. M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to Stress in Young Rats after 2-week Zinc Deprivation. Neurochem. Int. 56,
410-416, 2010.
89. Wuritu, Y. Ozawa, Gaowa, F. Kawamori, T. Masuda, T. Masuzawa, H. Fujita, N. Ohashi: Structural analysis of a p44/msp2 expression site ofAnaplasma phagocytophilum in naturally infected ticks in Japan. J. Med. Microbiol. 58, 1638-1644, 2009.
90. S. Yamada, C. Takeuchi, L. Oyunzul, Y. Ito: Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet obstruction. Eur.
Urol. 55, 482-489, 2009.
91. T. Yamada, T. Terashima, R. Kawano, R. Furuno, T. Okubo, L. R. Juneja, H. Yokogoshi: Theanine, γ-glutamylethylamide, a unique amino acid in
tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino Acids, 36(1), 21-27, 2009.
92. T. Yamada, Y. Yamada, Y. Okano, T. Terashima, H. Yokogoshi: Anxiolytic effects of short- and long-term administration of cacao mass on rat
elevated T-maze test. J. Nutr. Biochem. 20, 948-955, 2009.
93. N. Yamaguchi, S. Miyamoto, Y. Ogura, T. Goda, K. Suruga: Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein
type II gene expression in intestinal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296, 524-533, 2009.
94. T. Yamauchi, Y. Johzuka-Hisatomi, S. Fukada-Tanaka, R. Terada, I. Nakamura, S. Iida: Homologous recombination-mediated knock-in targetingof the MET1a gene for maintenance DNA methyltransferase reproducibly reveals dosage-dependent spatiotemporal gene expression in rice.
Plant J. 60, 386-396, 2009.
95. K. Yasui, H. Tanabe, N. Okada, R. Fukutomi, Y. Ishigami, M. Isemura: Effects of chronic ingestion of catechin-rich green tea on hepatic gene
expression of gluconeogenic enzymes in rats. Biomed. Res. 30, 25-29, 2009.
96. S. Yokoshima, Y. Abe, N. Watanabe, Y. Kita, T. Kan, T. Iwatsubo, T. Tomita, T. Fukuyama: Development of Photoaffinity Probes for
γ-Secretase Equipped with a Nitrobenzenesulfonamide-type Cleavable Linker. Bioorg. Med. Chem. Lett. 20, 1798-1799, 2010.
97. A. Yokoyama, H. Sakakibara, A. Crozier, Y. Kawai, A. Matsui, J. Terao, S. Kumazawa, K. Shimoi: Quercetin metabolites and protection against
peroxynitrite-induced oxidative hepatic injury in rats. Free Radical Res. 43(10), 913-921, 2009.
98. N. Yoshimura, M. Nakayama: Nominative case marking and verb inflection in L2 grammar: Evidence from Japanese college students’composition. In Otsu, Yukio (ed.) The Proceedings of the 2009 Tokyo Conference on Psycholinguistics 359-383. Tokyo: Hituzi Syobo, 2009.
99. N. Yoshimura, M. Nakayama: Acquisition of two types of -s by Japanese EFL Learners: The role of L1 transfer. In Y-S. Yang, S-W. Tang, C. Kim,
J-Y. Yoon, Y-S. Kang, K-A. Kim, H. Yoo, Y. Jang, and H-K. Kang (eds.), Current Issues in Linguistic Interfaces, 2. 253-263. Seoul, Korea: Hankook
Munhwasa. 2009.
100. 藤野知美 , 伊藤由彦 , 瀧優子 , 柿澤希実 , 尾上誠良 , 今井康之 , 奥直人 , 野口博司 , 伊藤邦彦 , 小林裕和 , 大橋典男 , 合田敏尚 , 木苗直秀 , 梅垣敬三 , 渡邉裕司 , 山田静雄： Warfarin とビタミン K の相互作用に関する文献的研究．臨床薬理 , 41, 43-52, 2010.

97

事業推進担当者・若手研究者の研究業績（原著論文）

平成22年度（2010−2011年）

平成22年度には拠点を形成する５専攻全体で326報の英文学術論文（IFの合計：888.555）を発表した。
（以下は事業推進担当者および若手研究者が発表した主な原著論文）

1. M. Ando, N. Oku, A. Takeda: Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin. Neurochem.
Int. 57, 608-614, 2010.
2. T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku, T. Kan: PET
Imaging of Nobiletin Based on a Practical Total Synthesis. Chem Commun. 47, 2868-2870, 2011.
3. D. A. Boltz, B. Douangngeun, P. Phommachanh, S. Sinthasak, R. Mondry, C. Obert, P. Seiler, R. Keating, Y. Suzuki, H. Hiramatsu, E. A.
Govorkova, R. G. Webster: Emergence of H5N1 Avian Influenza Viruses with Reduced Sensitivity to Neuraminidase Inhibitors and Novel
Reassortants in LAO PDR. J. Gen Virol. 91, 949-959, 2010.
4. T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, A. Sumino, K. Niwata, T. Umemoto, K. Iida, N. Oku, Mamoru Nango: Liposomal
polyamine-dialkyl phosphate conjugates as effective gene carriers: Chemical structure, morphology, and gene transfer activity. Bioconjugate
Chem. 21, 844-852, 2010.
5. S. Fujimoto, K. Mochizuki, M. Shimada, T. Hori, Y. Murayama, N. Ohashi, T. Goda: Insulin resistance induced by a high-fat diet is associatedwith the induction of genes related to leukocyte activation in rat peripheral leukocytes. Life Sci. 87, 679-685 ,2010.
6. S. Fujimoto, T. Goda, K. Mochizuki: In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of
diabetic db/db mice. Biochem. Biophys. Res. Commu. 404, 223-227, 2011.
7. T. Furuta, J. Yamamoto, Y. Kitamura, A. Hashimoto, H. Masu, I. Azumaya, T. Kan, T. Kawabata: Synthesis of Axially Chiral Amino Acid andAmino Alcohols via Additive-Ligand-Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the ProductAmidoaza[5]helicene. J. Org. Chem. 75, 7010-7013, 2010.
8. J. Hatanaka, H. Chikamori, H. Sato, S. Uchida, K. Debari, S. Onoue, S. Yamada: Physicochemical and pharmacological characterization of
α-tocopherol loaded nano-emulsion system. Int. J. Pharm. 396: 188-193, 2010.
9. T. Hayashi, M. Nakamichi, H. Naitou, N. Ohashi, Y. Imai, M. Miyake: Proteomic analysis of growth phase-dependent expression of Legionella
pneumophila proteins for identifying novel virulence-associated factors. PLoS One, 22, e11718, 2010.
10. T. Higashi, T. Ichikawa, S. Inagaki, J.Z. Min, T. Fukushima, T. Toyo’oka: Simple and practical derivatization procedure for enhanced detection ofcarboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal. 52, 809-818, 2010.
11. T. Higashi, Y. Isobe, H. Ouchi, H. Suzuki, Y. Okazaki, T. Asakawa, T. Furuta, T. Wakimoto, T. Kan: Stereocntrolled Synthesis of(+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid. Org. Lett. 13, 1089-1091, 2011.
12. J. Hirakawa, K. Tsuboi, K. Sato, M. Kobayashi, S. Watanabe, A. Takakura, Y. Imai, Y. Ito, M. Fukuda, H. Kawashima: Novel anti-carbohydrate
antibodies reveal the cooperative function of sulfated N- and O-glycan in lymphocyte homing. J. Biol. Chem. 285, 40864-40878, 2010.
13. M. Hiroi, Y. Nagahara, R. Miyauchi, Y. Misaki, T. Goda, N. Kasezawa, S. Sasaki, K. Yamakawa-Kobayashi: The Combination of Genetic Variationsin the PRDX3 Gene and Dietary Fat Intake Contribute to Obesity Risk. Obesity, 19, 882-887, 2011.
14. T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cellline HepG2 by the calcium channel blocker nicardipine. Cancer Sci.101, 652-657, 2010.
15. Y. Hoshino, H. Koide, T. Urakami, H. Kanazawa, T. Kodama, N. Oku, KJ. Shea: Recognition, neutralization, and clearance of target peptides inthe bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody. J. Am. Chem. Soc. 132, 6644-6645, 2010.
16. S. Ieda, T. Kan, T. Fukuyama: Synthesis of the Optically Active Key Intermediate of FR901483. Tetrahedron Letters, 51, 4027-4029, 2010.
17. A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16
mediated by ERK-dependent phosphorylation. Biochim Biophys Acta. 1798 (3), 415-421, 2010.
18. A. Ikari, A. Sanada, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa: Up-regulation of TRPM6 transcriptional activity by AP-1 in renal
epithelial cells. J Cell Physiol. 222, 481-487, 2010.
19. A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby
canine kidney cells. J Cell Physiol. 226, 1471-1478, 2011.
20. A. Ikari, K. Atomi, K. Kinjo, Y. Sasaki, J. Sugatani: Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial
Madin-Darby canine kidney cells. Life Sci. 86, 766-773, 2010.
21. Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal
Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commu. 392, 16-21, 2010.
22. T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea
catechins for HSA: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol. Nutr. Food Res. 54,
816-822, 2010.
23. T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free
Radic. Res. 44, 403-409, 2010.
24. T. Ishii, T. Mori, T. Ichikawa, M. Kaku, K. Kusaka, Y. Uekusa, M. Akagawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Structuralcharacteristics of green tea catechins for formation of protein carbonyl in human serum albumin. Bioorg. Med. Chem. 18, 4892-4896, 2010.
25. T. Itoh, H. Takemura, K. Shimoi, K. Yamamoto K: A 3D model of CYP1B1 explains the Dominant 4-hydroxylation of estradiol, J. Chem. Inf.
Model. 50(6), 1173-1178, 2010.
26. I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose
transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem. 22, 334-343,
2011.

98

事業推進担当者・若手研究者の研究業績（原著論文）

27. R. K. Saha, T. Takahashi, Y. Kurebayashi, K. Fukushima, A. Minami, N. Kinbara, M. Ichitani, Y. M. Sagesaka, T. Suzuki: Antiviral effect of strictinin
on influenza virus replication. Antiviral Res. 88, 10-18, 2010.
28. H. Kako, Y. Kobayashi, H. Yokogoshi: Effects of n-hexanal on dopamine release in the striatum of living rats. Eur. J. Pharmacol. 2010 Nov 30.
[Epub ahead of print] PubMed PMID: 21114973.
29. H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation and the
suppression of genes related to insulin sensitivity induced by TNF-α. Nutrition 26, 1151-1156, 2010.
30. Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy withliposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer, 127, 2685-2698, 2010.
31. A. Kato, H. Naitou, M. Namioka, M. Akimoto, T. Ishii, H. Sakakibara, K. Shimoi, T. Nakayama, N. Ohashi: Proteomic identification of serum
proteins associated with stress-induced gastric ulcers in fasted rats. Biosci. Biotech. Biochem. 74, 812-818, 2010.
32. Y. Kato, H. Suzuki, K. Haraguchi, S. Ikushiro, Y. Ito, S. Uchida, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum
thyroxine level by phenobarbital in rodents. Toxicol. Appl. Pharmacol. 249, 238-246, 2010.
33. Y. Kato, K. Haraguchi, M. Kubota, Y. Seto, T. Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease inserum thyroxine level by a 2,3,7,8-tetrachlorodibenzo- p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl inmice. Drug Metab. Dispos. 38, 150-156, 2010.
34. Y. Kato, K. Haraguchi, Y. Ito, A. Fujii, T. Yamazaki, T. Endo, N. Koga, S.Yamada, M. Degawa: Polychlorinated biphenyl-mediated decrease inserum thyroxine level in rodents. Drug Metab. Dispos. 38, 697-704, 2010.
35. D. Kato, S. Era, I. Watanabe, M. Arihara, N. Sugiura, K. Kimata, Y. Suzuki, K. Morita, K. I.P.J. Hidari, T. Suzuki: Antiviral activity of chondroitin
sulphate E targeting dengue virus envelope protein. Antiviral Res. 88, 236-243, 2010.
36. K. Kawai, K. Kaku, N. Izawa, M. Shimizu, H. Kobayashi, T. Shimizu: Transformation of Arabidopsis by mutated acetolactate synthase genes fromrice and Arabidopsis that confer specific resistance to pyrimidinylcarboxylate-type ALS inhibitors. Plant Biotech. 27, 75-84, 2010.
37. K. Kobata, K. Saito, H. Tate, A. Nashimoto, H. Okuda, I. Takemura, K. Miaykawa, M. Takahashi, K. Iwai, T. Watanabe: Long chain
N-vanillyl-acylamides from Capsicum oleoresin. J. Agric. Food Chem. 58, 3627-3631, 2010.
38. Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of
dopamine release from PC12 cells by the green odor compound hexanal. Cellular and Molecular Neurobiology, 30, 173-184, 2010.
39. M. Kojima, M. Sekimoto, M. Degawa: Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver. J. Endocrinol. 207,
203-211, 2010.
40. K. Koyama, A. Ito, J. Yamamoto, T. Nishio, J. Kajikuri, Y. Dohi, N. Ohte, A. Sano, H. Nakamura, H. Kumagai, T. Itoh: Randomized controlled trialof the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term
hemodialysis. Am. J. Kidney Dis. 55, 1069-1078, 2010.
41. Y-L Lai, S. Aoyama, R. Nagai, N. Miyoshi, H. Ohshima: Inhibitation of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced
Glycation End Products. J. Clin. Biochem. Nutr. 46:177-85, 2010.
42. T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett. 192,
97-100, 2010.
43. T. Matsuda, T. Maruyama, H. Iizuka, A. Kondo, T. Tamai, K. Kurohane, Y. Imai: Phthalate esters reveal skin-sensitizing activity of phenethyl
isothiocyanate in mice. Food Chem. Toxicol. 48, 1704-1708, 2010.
44. S. Misaka, S. Uchida, H. Imai, N. Inui, S. Nishio, K. Ohashi, H. Watanabe, S. Yamada: Pharmacokinetics and pharmacodynamics of low doses of
midazolam administered intravenously and orally to healthy volunteers. Clin. Exp. Pharmacol. Physiol. 37: 290-295, 2010.
45. Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma interleukin-1β concentrations are closely associatedwith fasting blood glucose levels in healthy and preclinical middle-aged non-overweight and overweight Japanese men. Metabolism, 59,
1465-1471, 2010.
46. N. Miyoshi, T. Nagasawa, R. Mabuchi, Y. Yasui, K. Wakabayashi, T. Tanaka, H. Ohshima: Chemoprevention of azoxymethane/dextran sodium
sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev. Res. 4, 924-934, 2011.
47. N. Miyoshi, Y. Wakao, S. Tomono, M. Tatemichi, T. Yan, H. Ohshima: The enhancement of the oral bioavailability of γ-tocotorienol in mice by
γ-cyclodextrin inclusion. J. Nutr. Biochem. 22, 1121-1126, 2011.
48. K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat
diet in mice. Mol. Nutr. Food Res. 54, 1445-1451, 2010.
49. K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the
α-glucosidase inhibitor miglitol. Metabolism, 59, 1442-1447, 2010.
50. K. Mochizuki, N. Fukaya, Y. Tanaka, M. Fuchigami, T. Goda: Treatment with the α-glucosidase inhibitor miglitol from the pre-onset stage in
OLETF rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes. Metabolism, 60,
1560-1565, 2011.
51. K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, N. Miyoshi, Y. Ichikawa, T. Goda: Circulating interleukin-1β and interleukin-6
concentrations are closely associated with γ-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovasculardiseases. Metabolism, 60, 914-922, 2011.
52. K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated
galactose on glycosylated chain of S-I complex. Life Sci. 86, 524-531, 2010.
53. K. Mochizuki, Y. Sato, S. Takase, T. Goda: Changes in mucosal α-glucosidase activities along the jejunal-ileal axis by an hm-HACS diet intake
are associated with decreased lipogenic enzyme activity in epididymal adipose tissue. J. Agr. Food Chem. 58, 6923-6927, 2010.

99

事業推進担当者・若手研究者の研究業績（原著論文）

54. Y. Murase, T. Asai, Y. Katanasaka, T. Sugiyama, K. Shimizu, N. Maeda, N. Oku: A novel DDS strategy, “dual-targeting” , and its application for
antineovascular therapy. Cancer Lett. 287, 165-171, 2010.

事業推進担当者・若手研究者の研究業績（原著論文）

78. A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc differentially acts on components of long-term potentiation at hippocampal
CA1 synapse. Brain Res. 1323, 59-64, 2010.

55. C. A. Nidom, R. Takano, S. Yamada, Y. Sakai-Tagawa, S. Daulay, D. Aswadi, T. Suzuki, Y. Suzuki, K. Shinya, K. Iwatsuki-Horimoto, Y. Muramoto,Y. Kawaoka: Influenza A (H5N1) viruses from pigs, Indonesia. Emerg. Infect. Dis. 16, 1515-1523, 2010.
56. Y. Ohmichi, J. Hirakawa, Y. Imai, M. Fukuda, H. Kawashima: Essential role of peripheral node addressin in lymphocyte homing tonasal-associated lymphoid tissues and allergic immune responses. J. Exp. Med. 208, 1015-1025, 2011.
57. S. Onoue, H. Takahashi, Y. Kawabata, Y. Seto, J. Hatanaka, B.N. Timmermann, S. Yamada: Formulation design and photochemical studies on
nanocrystal solid dispersion of curcumin with improved oral bioavailability. J. Pharm. Sci. 99: 1871-1881, 2010.
58. T. Osonoi, M. Saito, K. Mochizuki, N. Fukaya, T. Muramatsu, S. Inoue, M. Fuchigami, T. Goda: The α-glucosidase inhibitor miglitol decreases
glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes. Metabolism,
59, 1816-1822, 2010.

79. A. Takeda, M. Suzuki, H. Tamano, M. Ando, N. Oku: Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent
induction of hippocampal CA1 LTP components. Brain Res. 1354: 188-195, 2010.
80. A. Takeda, S. Takada, M. Ando, K. Itagaki, H. Tamano, M. Suzuki, H. Iwaki, N, Oku: Impairment of recognition memory and hippocampal
long-term potentiation after acute exposure to clioquinol. Neuroscience, 171, 443-450, 2010.
81. N. Takemae, R. Ruttanapumma, S. Parchariyanon, S. Yoneyama, T. Hayashi, H. Hiramatsu, N. Sriwilaijaroen, Y. Uchida, S. Kondo, H. Yagi, K.
Kato, Y. Suzuki, T. Saito: Alterations in receptor binding properties of swine influenza viruses of H1 subtype after isolation in embryonatedchicken eggs. J. Gen. Virol. 91, 938-948, 2010.
82. H. Takemura, H. Nagayoshi, T. Matsuda, H. Sakakibara, M. Morita, A. Matsui, T. Ohura, K. Shimoi: Inhibitory effects of chrysoeriol on DNA
adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells, Toxicol. 274(1-3), 42-48, 2010.

59. S. Piyaviriyakul, K. Shimizu, T. Asakawa, T. Kan, P. Siripong, N. Oku: Anti-angiogenic activity and intracellular distribution of
epigallalocatechin-3-gallate analogs. Biol. Pharm. Bull. 34, 396-400, 2011.
60. M. Saito, E. Kazuyama, S. Shimizu, F. Dimitriadis, Y. Kinoshita, E. Masuda, S. Yamada, K. Satoh: Muscarinic receptors and their mRNAs in type 2
Goto-Kakizaki diabetic rat prostate. Prostate, 70: 1533-1539, 2010.
61. R. Saito, S. Ohkawa, S. Ichinose, M. Nishikino, N. Ikegaya, H. Kumagai: Validity of mid-arm muscular area measured by anthropometry innonobese patients with increased muscle atrophy and variation of subcutaneous fat thickness. Eur J Clin Nutr. 64, 899-904, 2010.

83. H. Takemura, T. Itoh, K. Yamamoto, H. Sakakibara, K. Shimoi: Selective inhibition of methoxyflavonoids on human CYP1B1 activity, Bioorg.
Med. Chem. 18(17), 6310-6315, 2010.
84. H. Takemura, H. Uchiyama, T. Ohura, H. Sakakibara, R. Kuruto, T. Amagai, K. Shimoi: A methoxyflavonoid, chrysoeriol, selectively inhibits theformation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. J. Steroid Biochem. Mol. Biol. 118(1-2), 70-76, 2010.
85. H. Tamano, F. Kan, N. Oku, A. Takeda: Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient
young mice. Brain Res. Bull. 83, 351-355, 2010.

62. M. Sakaguchi, T. Ohura, T. Iwata, S Takahashi, S. Akai, T. Kan, H. Murai, M. Fujiwara, O. Watanabe, M. Narita: Diblock Copolymer of Bacterial

86. T. Tanikawa, K. Kurohane, Y. Imai: Regulatory effect of lysophosphatidic acid on lymphocyte migration. Biol. Pharm. Bull. 33, 204-208, 2010.

Cellulose and Poly(methyl methacrylate) Initiated by Chain-End-Type Radicals Produced by Mechanical Scission of Glycosidic Linkages of

87. Y. Terada, M. Narukawa, T. Watanabe: Specific hydroxyl fatty acids in royal jelly activate TRPA1. J. Agric.Food Chem. 59, 2627-2635, 2011.

Bacterial Cellulose. Biomacromolecules ACS 11, 3059-3066, 2010.

88. Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective

63. Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole)
sulfone. SYNLETT, 827-827, 2010.

function in experimental colitis in mice. J. Biol. Chem. 285, 6750-6760, 2010.
89. K. Tomiyama, H. Nakashima, Y. Arakawa, H. Kumagai: Mechanism underlying the olfactory disturbance induced by an intraperitoneal injection

64. H. Sakakibara, CPN. Romanowski, V. Jakubcakova, C. Flachskamm, K. Shimoi, M. Kimura: Feeble awake effects of plasminogen activator
inhibitor type-1 in mice. Behav. Brain Res. 220, 354-357, 2011.

of tributyltin chloride in rats. Toxicology, 276, 110-114, 2010.
90. S. Tomono, N. Miyoshi, H. Shiokawa, T. Iwabuchi, Y. Aratani, T. Higashi, H. Nukaya, H. Ohshima: Formation of cholesterol ozonolysis products

65. M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histoneson the Thrsp gene in the jejunum. J. Agr. Food Chem. 59, 1464-1469, 2011.
66. K. Shimizu, M. Osada, K. Takemoto, Y. Yamamoto, T. Asai, N. Oku: Temperature-dependent transfer of amphotericin B from liposomal
membrane of AmBisome to fungal cell membrane. J. Control. Release, 141, 208-215, 2010.
67. M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, and H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control ofphotosystem stoichiometry. Proc. Natl. Acad. Sci. USA, 107, 10760-10764, 2010.
68. M. Shinohara, K. Uchida, S. Shimada, K. Tomioka, N. Suzuki, T. Minegishi, S. Kawahashi, Y. Yoshikawa, N. Ohashi: Novel concentration method for
detection of norovirus and sapovirus from water using minute particles of amorphous calcium phosphate. J. Med. Microbiol. 60, 780-786, 2011.
69. N. Sriwilaijaroen, S. Kondo, H. Yagi, N. Takemae, T. Saito, H. Hiramatsu, K. Kato, Y. Suzuki: N-glycans from porcine trachea and lung:
Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor. PLoS ONE, 6(2), e-16302,
2011.

in vitro and in vivo through a myeloperoxidase-dependent pathway, J. Lipid. Res. 52(1): 87-97, 2011.
91. H. Tsutsui, T. Maeda, T. Toyo'oka, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa: Practical analytical approach for the identification of biomarker
candidates in prediabetic state based upon metabonomic study by ultra-performance liquid chromatography coupled to electrosprayionization time-of-flight mass spectrometry. J. Proteome Res. 9, 3912-3922, 2010.
92. H. Tsutsui, T. Maeda, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa, T. Toyo’oka: Biomarker discovery in biological specimens (plasma, hair, liver andkidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization
time-of-flight mass spectrometry. Clin. Chim. Acta. 412, 861-872, 2011.
93. T. Wakimoto, T. Asakawa, S. Akahoshi, T, Suzuki, K. Nagai, H. Kawagishi, T. Kan: Proof the existence of an unstable amino acid,pleurocybellaziridine, in Pleurocybella porrigens (angel’s wing mushroom). Angew. Chem. Int. Ed. 50, 1168-1170, 2011.
94. M. Watanabe, T. Hirokawa, T. Kobayashi, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto: Investigation of thebioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy. J. Med.

70. N. Sriwilaijaroen, A. Kadowaki, Y. Onishi, N. Gato, M. Ujike, T. Odagiri, M. Tashiro, Y. Suzuki: Mumefural and related HMF derivatives fromJapanese apricot fruit juice concentrate show multiple inhibitory effects on pandemic influenza A (H1N1) virus. Food Chem. 127, 1-9, 2011.
71. J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2
cells is mediated through suppression of cyclin-dependent kinase 2. Drug Metab. Dispos. 38, 177-186, 2010.
72. J. Sugatani, S. Sadamitsu, M. Kurosawa, S. Ikushiro, T. Sakaki, A. Ikari, M. Miwa: Nutritional status affects fluvastatin-induced hepatotoxicity andmyopathy in rats. Drug Metab. Dispos. 38, 1655-1664, 2010.

Chem. 53, 3585-3593, 2010.
95. M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to stress in young rats after 2-week zinc deprivation. Neurochem. Int. 56,
410-416, 2010.
96. T. Watanabe, K. Ohnuki, K. Kobata: Studies on the metabolism and toxicology of emerging capsinoids. Expert Opinion Drug Metab. Toxicol. 7,533-542, 2011.
97. S. Yamada, Y. Ito, Y. Taki, M. Seki, M. Nanri, F. Yamashita, K. Morishima, I. Komoto, K. Yoshida: The N-oxide metabolite contributes to bladder

73. T. Suzuki, V. Douard, K. Mochizuki, T. Goda, R. Ferraris: Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter
GLUT5 during development of rat small intestine. Biochem. J. 435, 43-53, 2011.
74. M. Takaguchi, T. Takahashi, C. Hosokawa, H. Ueyama, K. Fukushima, T. Hayakawa, K. Itoh, K. Ikeda, T. Suzuki: A single amino acid mutation at
position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell
death. J. Biochem. 149, 191-202, 2011.

selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics. Drug Metab. Dis. 38, 1314-1321, 2010.
98. T. Yamanaka, K. Tsujimura, T. Kondo, T. Matsumura, H. Ishida, M. Kiso, K. IP J. Hidari, T. Suzuki: Infectivity and pathogenicity of canine H3N8
influenza a virus in horses. Influenza Other Respi. Viruses, 4, 345-351, 2010.
99. A. Yoshida, S. Maruyama, D. Fukumoto, H. Tsukada, Y. Ito, S. Yamada: Noninvasive evaluation of brain muscarinic receptor occupancy of
oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography. Life Sci. 25, 175-180, 2010.

75. T. Takahashi, Y. Kurebayashi, K. Ikeya, T. Mizuno, K. Fukushima, H. Kawamoto, Y. Kawaoka, Y. Suzuki, T. Suzuki: The Low-pH Stability
Discovered in Neuraminidase of 1918 Pandemic Influenza A Virus Enhances Virus Replication. PLoS One, 5(12), e-15556, 2010.
76. T. Takahashi, H. Satoh, M. Takaguchi, S. Takafuji, H. Yokoyama, S. Fujii, T. Suzuki: Binding of sulfatide to recombinant hemagglutinin of influenza

100. A. Yoshida, Y. Hirooka, Y. Sugata, M. Nitta, T. Manabe, S. Ido, K. Murakami, R. K. Saha, T. Suzuki, M. Ohshima, A. Yoshida, K. Itoh, K. Shimizu,
N. Oku, T. Furuta, T. Asakawa, T. Wakimoto, T. Kan: Concise synthesis of catechin probes enabling analysis and imaging of EGCg. Chem.
Commun. 47, 1794-1796, 2011.

A virus produced by a baculovirus protein expression system. J. Biochem. 147, 459-462, 2010.
77. A. Takeda, H. Tamano, S. Imano, N. Oku: Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and theirroles in response to fear. Neuroscience, 168, 715-722, 2010.

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事業推進担当者・若手研究者の研究業績（原著論文）

平成23年度（2011−2012年）

事業推進担当者・若手研究者の研究業績（原著論文）

1. S. Akai, S. Ishida, K. Hatanaka, T. Ishii, N. Harada, H. Tsukada, N. Oku: Synthesis of long-chain [18F]deoxyfluoropoly(ethylene glycol) methyl
ethers and their non-invasive pharmacokinetic analysis by positron emission tomography. Mol. Pharm. 8, 302-308, 2011.
2. T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku: Dicetyl
phosphate-tetraetylenepentamine- based liposomes for systemic siRNA delivery. Bioconjug. Chem. 22, 429-435, 2011.
3. J. M. Barichello, S. Kizuki, T. Tagami, T. Asai, T. Ishida, H. Kikuchi, N. Oku, H. Kiwada: Agitation during lipoplex formation improves the geneknockdown effect of siRNA. Int. J. Pharm. 410, 153-160, 2011.
4. J. Chen, S. Yamada, Y. Hama, A. K. Shetty, T. Kobayashi, H. Oda, K. Seiki, E. Kim, T. Kimura, N. Takahashi, K. I.P.J. Hidari, T. Suzuki, Y. Suzuki, K.
Sugahara: Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis
virus. Biochem. Biophys. Res. Commun. 412(1) 136-142, 2011.
5. K. Fukushima, T. Takahashi, T. Masahiro, H. Ueyama, S. Ito, Y. Kurebayashi, T. Kawanishi, J.L. Mckimm-Breschkin, T. Takimoto, A. Minami, T.
Suzuki: Plaque formation assay for human parainfluenza virus type 1. Biol. Pharm. Bull. 34, 996-1000, 2011.
6. R. Furuya, H. Kumagai, T. Miyata, H. Fukasawa, S. Isobe, N. Kinoshita, A. Hishida: High plasma pentosidine level is accompanied withcardiovascular events in hemodialysis patients. Clin. Exp. Nephrol. 16, Dec 9 2011.
7. Gaowa, Wuritu, D. Wu, Y. Yoshikawa, N. Ohashi, F. Kawamori1, K. Sugiyama, M. Ohtake, M. Ohashi, S. Yamamoto, T. Kitano, N. Takada, H.
Kawabata: Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild
deer in Japan, Jpn. J. Infect. Dis. in press.
8. S. Haramizu, F. Kawabata, K. Ohnuki, N. Inoue, T. Watanabe, S. Yazawa, T. Fushiki: Capsiate, a non-pungent capsaicin analog, reduces body fat
without weight rebound like swimming exercise in mice. Biomed. Res. 32(4), 279-284, 2011.
9. M. Hayashi-Tsugane, M. Maekawa, Q. Qian, H. Kobayashi, S. Iida, K. Tsugane: A rice mutant displaying a heterochronically elongatedinternode carries a 100 kb deletion. J. Genet. Genomics 38, 123-128, 2011.
10. M. Hayashi-Tsugane, M. Maekawa, H. Kobayashi, S. Iida, K. Tsugane: Examination of transpositional activity of nDart1 at different stages of ricedevelopment. Genes Genet. Syst. 86, 215-219, 2011.
11. T. Higashi, M. Suzuki, J. Hanai, S. Inagaki, J. Z. Min, K. Shimada, T. Toyo’oka: A specific LC/ESI-MS/MS method for determination of
25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3. J. Sep. Sci. 34,
725-732, 2011.
12. T. Higashi, T. Ichikawa, C. Shimizu, S. Nagai, S. Inagaki, J. Z. Min, H. Chiba, S. Ikegawa, T. Toyo’oka: Stable isotope-dilution liquid
chromatography/tandem mass spectrometry method for determination of thyroxine in saliva. J. Chromatogr. B. 879, 1013-1017, 2011.
13. Y. Higuchi, K. Sage-Ono, R. Sasaki, N. Ohtsuki, A. Hoshino, S. Iida, H. Kamada, M. Ono: Constitutive expression of the GIGANTEA ortholog affects
circadian rhythms and suppresses one-shot induction of flowering in Pharbitis nil, a typical short-day plant. Plant Cell Physiol. 52, 638-650, 2011.
14. M. Hiroi, T. Harada, F. Kawamori, N. Takahashi, T. Kanda, K. Sugiyama, T. Masuda, Y. Yoshikawa, N. Ohashi: A survey ofβ-lactamase-producing Escherichia coli in farm animals and raw retail meat in Shizuoka prefecture, Japan. Jpn. J. Infect. Dis. 64, 153-155, 2011.
15. Y. Hoshino, H. Koide, K. Furuya , W.W. Haberaecker, S.H. Lee, T. Kodama, H. Kanawaza, N. Oku, K.J. Shea: The rational design of a synthetic
polymer nanoparticle that neutralizes a toxic peptide in vivo. Proc. Natl. Acad. Sci. USA, 109, 33-38, 2012.
16. A. Ikari, A. Sanada, H. Sawada, C. Okude, C. Tonegawa, J. Sugatani: Decrease in transient receptor potential melastatin 6 mRNA stability
caused by rapamycin in renal tubular epithelial cells. Biochim. Biophys. Acta. 1808, 1502-1508, 2011.
17. A. Ikari, A. Takiguchi, K. Atomi, J. Sugatani: Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2
protein in MDCK II cells. J. Cell. Physiol. 226, 2448-2456, 2011.
18. A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby
canine kidney cells. J. Cell. Physiol. 226, 1471-1478, 2011.
19. A. Ikari, H. Sawada, A. Sanada, C. Tonegawa, Y. Yamazaki, J. Sugatani: Magnesium deficiency suppresses cell cycle progression mediated byincrease in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells. J. Cell. Biochem. 112, 3563-3572, 2011.
20. A. Ikari, T. Sato, A. Takiguchi, K. Atomi, Y. Yamazaki, J. Sugatani: Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell
migration via suppression of nuclear Sp1 in A549 cells. Life Sci. 88, 628-633, 2011.
21. M. Imai, T. Watanabe, M. Hatta, S-C Das, M. Ozawa, K. Shinya, G. Zhong, A. Hanson, H. Katsura, S. Watanabe, C. Li, E. Kawakami, S. Yamada,
M. Kiso, Y. Suzuki, E-A Maher, G. Neumann, Y. Kawaoka: Experimental adaptation of an influenza H5 haemagglutinin confers respiratory
droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature, in press.
22. S. Inagaki, H. Hirashima, S. Taniguchi, T. Higashi, J. Z, Min, R. Kikura-Hanajiri, Y. Goda, T. Toyo’oka: Rapid enantiomeric separation andsimultaneous determination of phenethylamines by ultra high-performance liquid chromatography with fluorescence and mass spectrometricdetection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples. Drug Test. Anal. in press.
23. S. Inoue, K. Mochizuki, T. Goda: Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone
acetylation and binding of GCN5 on the genes. J. Nutr. Sci. Vitaminol., 57, 162-169, 2011.
24. T. Ishii, Y. Ichikawa, K. Minoda, K. Kusaka, S. Ito, Y. Suzuki, M. Akagawa, K. Mochizuki, T. Goda, T. Nakayama: Human serum albumin as anantioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. Biosci.
Biotechnol. Biochem., 75, 100-106, 2011.
25. K. Ito, S. Ito, T. Shimamura, S. Weyand, Y. Kawarasaki, T. Misaka, K. Abe, T. Kobayashi, A.D. Cameron, S. Iwata: Crystal structure of
glucansucrase from dental caries pathogen Streptococcus mutans. J. Mol. Biol. 408, 177-186, 2011.

26. Y. Iwasaki, Y. Tamura, K. Inayoshi, M. Narukawa, K. Kobata, H. Chiba, E. Muraki, N. Tsunoda, T. Watanabe: Effect of monoacylglycerol on
diet-induced obesity in mice. Biosci. Biotechnol. Biochem. 75(5), 904-909, 2011.
27. Y. Johzuka-Hisatomi, H. Noguchi, S. Iida: The molecular basis of incomplete dominance at the A locus of CHS-D in the common morning glory,
Ipomoea purpurea. J. Plant Res. 124, 299-304, 2011.
28. T. Kanehira, Y. Nakamura, K. Nakamura, K. Horie, N. Horie, K. Furugori, Y. Sauchi, H. Yokogoshi: Relieving occupational fatigue by
consumption of a beverage containing γ–amino butyric acid. J. Nutr. Sci. Vitaminol. 57, 9-15, 2011.
29. Y. Kato, M. Onishi, K. Haraguchi, S. Ikushiro, C. Ota, N. Koga, T. Endo, S. Yamada, M. Degawa: A possible mechanism for 2,2',4,4',5,5'-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Toxicol. Appl. Pharmacol. 254, 48-55, 2011.
30. K. Kimata, M. Yamaguchi, Y. Saito, H. Hata, K. Miyake, T. Yamane, Y. Nakagawa, A. Yano, K. Ito, Y. Kawarasaki: High cell-density expression
system: A novel method for extracellular production of "difficult-to-express" proteins. J. Biosci. Bioeng. 113, 154-159, 2012.
31. K. Kobata, M. Mimura, M. Sugawara, T. Watanabe: Synthesis of stable isotope-labeled precursors for the biosyntheses of capsaicinoids,
capsinoids, and capsiconinoids. Biosci. Biotechnol. Biochem. 75(8), 1611-1614, 2011.
32. A. Kobayashi, H. Yokoyama, J. Kataoka, T. Ishida, H. Kuno, S. Sugai, H. Sakakibara, K. Shimoi: Effects of spaced feeding on gene expression ofhepatic transaminase and gluconeogenic enzymes in rats. J. Toxicol. Sci. 36(3), 325-37, 2011.
33. C. Kobayashi, K. Kurohane, Y. Imai: High dose dietary pyridoxine induces T-helper type 1 polarization and decreases contact hypersensitivity
response to fluorescein isothiocyanate in mice. Biol. Pharm. Bull. in press.
34. H. Koide, T. Asai, K. Furuya, T. Tsuzuku, H. Kato, T. Dewa, M. Nango, N. Maeda, N. Oku: Inhibition of Akt(ser473) Phosphorylation andRapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial
Growth Factor Receptor-1-Targeting Vector. Biol. Pharm. Bull. 34, 602-608, 2011.
35. T. Kojima, N. Nagao, D. Ando, T. Ojima, Y. Kawarasaki, I. Kobayashi, M. Nakajima, H. Nakano: Emulsion culture: A miniaturized library
screening system based on micro-droplets in an emulsified medium. J. Biosci. Bioeng.112, 299-303, 2011.
36. M. Kojima, T. Ashino, T. Yoshida, Y. Iwakura, M. Degawa: Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating
the expression of Cyp7a1 transcriptional regulators in the mouse liver. Biol. Pharm. Bull. 34, 1644-1647, 2011.
37. YL. Lai, S. Aoyama, M. Ohata, N. Otsuka, H. Shiokawa, S. Tomono, Y. Fujiwara, H. Kanazawa, N. Miyoshi, H. Ohshima: Dysregulation ofdimethylargininedimethylaminohydrolase/asymmetricdimethylarginine pathway in rat type II diabetic nephropathy. J.Clin.Biochem.Nutr. in press.
38. YL. Lai, S. Tomono, N. Miyoshi, H. Ohshima: Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by theoxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. J. Clin. Biochem. Nutr. 50, 84-89,
2012.
39. R. Mabuchi, A. Kurita, N. Miyoshi, A. Yokoyama, T. Furuta, T. Goda, Y. Suwa, T. Kan, T. Amagai, H. Ohshima: Analysis of Nε-ethyllysine inhuman plasma proteins by gas chromatography- negative ion chemical ionization/mass spectrometry as a biomarker for exposure toacetaldehyde and alcohol. Alcohol. Clin. Exp. Res. in press.
40. S. Matsumoto, T. Asakawa, Y. Hamashima, T. Kan: A Short-step Asymmetric Synthesis of Dehydrodiconiferyl Alcohol by Means of C-H
Insertion Reaction. Synlett, in press.
41. K. Matsumoto, T. Takeuchi, N. Yokoyama, Y. Katagiri, M. Ooshiro, S. Zakimi, Gaowa, F. Kawamori, N. Ohashi, H. Inokuma: Detection of the
new Ehrlichia species closely related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan. J. Vet. Med. Sci., 73,
1485-1488, 2011.
42. J. Z. Min, H. Yano, A. Matsumoto, H-f Yu, Q. Shi, T. Higashi, S. Inagaki, T. Toyo’oka: Simultaneous determination of polyamines in human nailas 4-(N,N-dimethylaminosulfonyl)-7-fluoro- 2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flighttandem mass spectrometry. Clin. Chim. Acta. 412, 98-106, 2011.
43. J. Z. Min, S. Hatanaka, H-f Yu, T. Higashi, S. Inagaki, T. Toyo’oka: Determination of DL-amino acids, derivatized with R(-)-4(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS. J.
Chromatogr. B 879, 3220-3228, 2011.
44. J. Z. Min, Y. Suzuki, Y. Tomiyasu, D. Jin, T. Higashi, Y-I Lee, T. Toyo’oka: Development of novel active acceptors possessing a positively charged
structure for the transglycosylation reaction with Endo-M and their application to oligosaccharide analysis. Rapid. Commun. Mass Spectrom. 25,
2911-2922, 2011.
45. A. Minami, H. Shimizu, Y. Meguro, N. Shibata, H. Kanazawa, K. Ikeda, T. Suzuki: Imaging of sialidase activity in rat brain sections by a highly
sensitive fluorescent histochemical method. NeuroImage, 58, 34-40, 2011.
46. S. Misaka, R. Nakamura, S. Uchida, K. Takeuchi, N. Takahashi, N. Inui, K. Kosuge, S. Yamada, H. Watanabe: Effect of two weeks consumption of
pomegranate juice on the pharmacokinetics of single dose of midazolam: an open-labeled, randomized, single-center, two-period crossoverstudy in healthy Japanese volunteers. Clin Therap. 33, 246-252, 2011.
47. K. Miyamoto, S. Higashino, K. Mochizuki, T. Goda, K. Koyama: Evaluation of weight loss in the community-dwelling elderly with dementia asassessed by eating behavior and mental status. Asia Pac. J. Clin. Nutr. 20, 9-13, 2011.
48. K. Mochizuki, A. Ishihara, T. Goda, K. Yamauchi: RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are
key steps for thyroid hormone receptor b gene activation by thyroid hormone in Rana catesbeiana tadpole liver. Biochem. Biophys. Res.
Commu. in press.
49. K. Mochizuki, R. Miyauchi, Y. Misaki, Y. Ichikawa, T. Goda: Principal component 1 score calculated from metabolic syndrome diagnostic
parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic
diseases. Eur. J. Nutr., in press.
50. K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, K. Kuriki, Y. Ichikawa, T. Goda: A higher rate of eating is associated with higher
circulating IL-1b concentrations in Japanese men without treatment for metabolic diseases. Nutrition, in press.

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以下は事業推進担当者および若手研究者が発表した主な原著論文（平成24年1月現在）

事業推進担当者・若手研究者の研究業績（原著論文）

事業推進担当者・若手研究者の研究業績（原著論文）

51. K. Nemoto, S. Ito, C. Yoshida, M. Miyata, M. Kojima, M. Degawa: Hepatic expression of spermatogenic genes and their transiently remarkable
downregulations in Wistar-Kyoto rats in response to lead nitrate-administration: strain-difference in the gene expression patterns. J. Toxicol.
Sci, 36, 357-364, 2011.
52. K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino :Development ofanti-HB-EGF immunoliposomes for the treatment of breast cancer. J. Control. Release, 2011.
53. R. Nishino, K. Ikeda, T. Hayakawa, T. Takahashi, T. Suzuki, M. Sato: Syntheses of 2-deoxy-2, 3-didehydro-N-acetylneuraminic acid analogues
modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1. Bioorg.
Med. Chem. 19, 2418-2427, 2011.
54. M. Ogata, M. Yano, M. Umemura, S. Murata, T., Park EY, Y. Kobayashi, T. Asai, N. Oku, N. Nakamura, I. Matsuo, T. Usui: Design and Synthesisof High-Avidity Tetravalent Glycoclusters as Probes for Sambucus sieboldiana Agglutinin and Characterization of their Binding Properties.
Bioconjug Chem. 23, 97-105, 2012.
55. Y. Ohhara, Y. Kayashima, Y. Hayashi, S. Kobayashi, K. Yamakawa-Kobayashi: Expression of β-adrenergic-like octopamine receptors during
Drosophila development. Zoolog.Sci. 29, 83-89, 2011.
56. S. Ohno, M. Hosokawa, A. Hoshino, Y. Kitamura, Y. Morita, K. I. Park, A. Nakashima, A. Deguchi, F. Tatsuzawa, M. Doi, S. Iida, S. Yazawa: A
bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin systhesis in dahlia (Dahlia variabilis) . J. Exp. Bot. 62, 5105-5116, 2011.
57. N. Oku, M. Yamashita, Y. Katayama, T. Urakami, K. Hatanaka, K. Shimizu, T. Asai, H. Tsukada, S. Akai, H. Kanazawa: PET imaging of brain
cancer with positron emitter-labeled liposomes. Int. J. Pharm. 403, 170-177, 2011.
58. S. Okuyama, K. Tashiro, N-V Lam, T. Hatakeyama, T. Terashima, H. Yokogoshi: Effect of the edible mushroom Mycoleptodonoides aitchisonii ontransient global ischemia-induced monoamine metabolism changes in rat cerebral cortex. J. Med. Food, 15(1), 96-99, 2012.
59. S. Onoue, A. Uchida, H. Takahashi, Y. Seto, Y. Kawabata, K. Ogawa, K. Yuminoki, N. Hashimoto, S. Yamada: Development of high-energy
amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci. 100,
3793-3801, 2011.
60. S. Onoue, Y. Seto, M. Ochi, R. Inoue, H. Ito, T. Hatano, S. Yamada: In vitro photochemical and phototoxicological characterization of major
constituents in St. John's Wort (Hypericum perforatum) extracts. Phytochemistry. 72, 1814-1820, 2011.
61. M. Pervin, N. Paeng, K. Yasui, S. Imai, M. Isemura, H. Yokogoshi, T. Nakayama: Effects of Lens culinaris agglutinin on gene expression of
gluconeogenic enzymes in the mouse intestine. J. Sci. Food Agric. in press.
62. K. Sakai-Kato, T. Hasegawa, A. Takaoka, M. Kato, T. Toyo’oka, N. Utsunomiya-Tate, T. Kawanishi: Controlled structure and properties ofsilicate nanoparticle networks for incorporation of biosystem components. Nanotechnology, 22, 205702 (pp1-8), 2011.
63. K. Shintaku, K. Uchida, Y. Suzuki, M. Kashio, Z. Yiming, Y. Takayama, T. Fushiki, T. Watanabe, S. Yazawa, M. Tominga: Activation of TRPA1 by anon-pungent capsaicin-like compound, capsiate.Br. J. Pharmacol. in press.
64. Y. Suzuki, N. Miyoshi, M. Isemura: Health-promoting effects of green tea. Proc. Japan Acad. Ser B. in press.
65. K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, K. Matsuoka: Synthesis and biological evaluation of sialic acid derivatives
containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors. Bioorganic &Medicinal Chemistry, 20, 446-454, 2012.
66. Y. Takanami, T. Nakayama: Evaluation of superoxide anion radicals generated from aqueous extract of particulate phase cigarette smoke byelectron spin resonance using 5,5-dimethyl-1-pyrroline-N-oxide. Biosci. Biotechnol. Biochem. 75, 34-39, 2011.
67. A. Takeda, H. Tamano, T. Ogawa, S. Takada, M. Ando, N. Oku, M. Watanabe: Significance of serum glucocorticoid and chelatable zinc indepression and cognition in zinc deficiency. Behav. Brain Res. 226, 259-264, 2012.
68. A. Takeda, H. Tamano, M. Suzuki, K. Sakamoto, N. Oku, H. Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, anamino acid in tea leaves and its effect on stress response. Cell. Mol. Neurobiol. 32, 41-48, 2012.
69. A. Takeda, K. Itagaki, M. Ando, N. Oku: Involvement of NMDA receptor subunits in zinc-mediated modification of CA1 LTP in the developing
hippocampus. J. Neurosci. Res. 90, 551-558, 2012.
70. A. Takeda, K. Sakamoto, H. Tamano, K. Fukura, N. Inui, S. W. Suh, S-J Won, H. Yokogoshi: Facilitated neurogenesis in the developing
hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell. Mol. Neurobiol. 31, 1079-1088, 2011.
71. A. Takeda, M. Suzuki, H. Tamano, S. Takada, K. Ide, N. Oku: Involvement of glucocorticoid-mediated Zn 2+ signaling in attenuation ofhippocampal CA1 LTP by acute stress. Neurochem. Int. in press.
72. A. Takeda, S. Takada, M. Nakamura, M. Suzuki, H. Tamano, M. Ando, N. Oku: Transient increase in Zn 2+ in hippocampal CA1 pyramidal
neurons causes reversible memory deficit. PLoS One, 6, e28615, 2011.
73. Y. Taki, E. Hagiwara, C. Hirose, K. Shinozuka, K. Umegaki, S. Yamada: Effects of Ginkgo biloba extract on the pharmacokinetics andpharmacodynamics of tolbutamide in protein-restricted rats. J. Pharm. Pharmacol. 63, 1238-1243, 2011.
74. T. Tanaka, T. Ishii, D. Mizuno, T. Mori, R. Yamaji, Y. Nakamura, S. Kumazawa, T. Nakayama, M. Akagawa: (-)-Epigallocatechin-3-gallate
suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68. Free Radic. Biol. Med. 50, 1324-1335,
2011.
75. T. Tanikawa, K. Kurohane, Y. Imai: Regulatory Effect of Cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biol.
Pharm. Bull. 34, 1090-1093, 2011.
76. Y. Tobisawa, T. Maruyama, T. Tanikawa, K. Nakanishi, K. Kurohane, Y. Imai: Establishment of recombinant hybrid-IgG/IgA immunoglobulin
specific for Shiga toxin. Scand. J. Immunol. 76, 574-584. 2011.

77. K. Tokutomi, T. Tagawa, M. Korenaga, M. Chiba, T. Asai, N. Watanabe, S. Takeoka, M. Handa, Y. Ikeda, N.Oku: Decoration of fibrinogenγ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets. Int. J. Pharm. 407,
151-157, 2011.
78. S. Tomono, N. Miyoshi, M. Ito, T. Higashi, H. Ohshima: A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol
ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine. J. Chromatogr. B. 879, 2802-2808,
2011.
79. H. Tsuboi, H. Sakakibara, K. Yamakawa-Kobayashi, A. Tatsumi, T. Inamori, R. Hamamoto, A. Suzuki, K. Shimoi: Val1483Ile polymorphism in thefatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress. J. Affect. Disorders, 134(1-3),
448-485, 2011.
80. K. Tsujioka, M. Ohsumi, K. Sakamoto, P. Thanapreedawat, M. Akao, M. Kim, K. Hayase, H. Yokogoshi: Effect of dietary γ–aminobutyric acid on
the brain protein synthesis rate in hypophysectomized aged rats. J. Nutr. Sci. Vitaminol. 57(4), 285-291, 2011.
81. Y. Uekusa, M. Kamihira-Ishijima, O. Sugimoto, T. Ishii, S. Kumazawa, K. Nakamura, K. Tanji, A. Naito, T. Nakayama: Interaction of epicatechingallate with phospholipid membranes as revealed by solid-state NMR spectroscopy. Biochim. Biophys. Acta. 1808, 1654-1660, 2011.
82. K. Unno, K. Fujitani, N. Takamori, F. Takabayashi, K.I. Maeda, H. Miyazaki, K. Iguchi, K. Shimoi, M. Hoshino: Theanine intake improves theshortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic. Res.
45(8), 966-974, 2011.
83. T. Wakimoto, H. Kondo, H. Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H.
Nukaya, K. Tsuji, T. Kan, I. Abe: Furan fatty acid as an anti-inflammatory component from green-lipped mussel, Perna canaliculus. Proc. Natl.
Acad. Sci. USA, 108, 17533-17537, 2011.
84. T. Wakimoto, K. Miyata, H. Ouchi, T. Asakawa, H. Nukaya, Y. Suwa, T. Kan: Enantioselective Total Synthesis of Aperidine. Org. Lett. 13,
2789-2791, 2011.
85. Y. Watanabe, M. S. Ibrahim, H. F. Ellakany, N. Kawashita, R. Mizuike, H. Hiramatsu, N. Sriwilaijaroen, T. Takagi, Y. Suzuki, K. Ikuta: Acquisition of
Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt. PLoS
Pathogens, 7(5), e-1002068, 2011.
86. S. Wichit, A. Jittmittraphap, K. I.P.J. Hidari, B. Thaisomboonsuk, S. Petmitr, S. Ubol, C. Aoki, S. Itonori, K. Morita, T. Suzuki, Y. Suzuki, W.
Janpangern: Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells. Microbiol.
and Immunol. 55, 135-140, 2011.
87. S. Yamada, K. Shinya, A. Takada, T. Ito, T. Suzuki, Y. Suzuki, Q. Le, M. Ebina, N. Kasai, H. Kida, T. Horimoto, P. Rivailler, L. Chen, R. Donis, Y.
Kawaoka: Adaptation of a duck influenza A virus in quail. J. Virol. 86, 1411-1420, 2012.
88. S. Yamada, M. Seki, M. Ogoda, A. Fukata, M. Nakamura, Y. Ito: Selective binding of bladder muscarinic receptors in relation to thepharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder. J. Pharmacol. Exp. Ther. 336, 365-371, 2011.
89. H. Yamaguchi, Y. Hirakura, H. Shirai, H. Mimura, T. Toyo’oka: Quantitative evaluation of protein conformation in pharmaceuticals using
cross-linking reactions coupled with LC-MS/MS analysis. J. Pharm. Biomed. Anal. 55, 574-582, 2011.
90. K. Yamakawa-Kobayashi, M. Natsume, S. Aoki, S. Nakano, T. Inamori, N. Kasezawa, T. Goda: The combined effect of the T2DM susceptibility
genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med. Genet. in press.
91. S. Yamamoto, S. Maruyama, Y. Ito, M. Kawamata, S. Nishiyama, H. Ohba, H. Tsukada, S. Yamada: Effect of oxybutynin and imidafenacin on
central muscarinic receptor occupancy and cognitive function: A monkey PET study with [11C](+)-3-MPB. NeuroImage. 58, 1-9, 2011.
92. Y. Yamazaki, T. Hashizume, H. Morioka, S. Sadamitsu, A. Ikari, M. Miwa, J. Sugatani: Diet-induced lipid accumlation in liver enhances ATP-biding
cassette transporter g5/g8 expression in bile canaliculi. Drug Metab. Pharmacokinet. 26, 442-450, 2011.
93. K. Yasui, H. Tanabe, N. Miyoshi, T. Suzuki, S. Goto, K. Taguchi, Y. Ishigami, N. Paeng, R. Fukutomi, S. Imai, M. Isemura: Effects of(-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum. Biomed. Res. 32, 313-320, 2011.
94. K. Yasui, N. Miyoshi, H. Tababe, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura: Effects of Oolong tea on gene expression of gluconeogenic
enzymes in the mouse liver and in rat hepatoma H4IIE cells. J. Med. Food, 14, 930-938, 2011. Epub 2011 Aug 3.
95. K. Yasui, N. Miyoshi, H. Tanabe, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura: Effects of a catechin-free fraction derived from green tea on gene
expression of gluconeogenic enzymes in rat hepatoma H4IIE cells and in the mouse liver. Biomed. Res. 32, 119-125, 2011.
96. K. Yasui, N. Paeng, N. Miyoshi, T. Suzuki, K. Taguchi, Y. Ishigami, R. Fukutomi, S. Imai, M. Isemura, T. Nakayama: Effects of a catechin-freefraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver. Biomed. Res. in press.
97. N. Yonenaga, E. Kenjo, T. Asai, A. Tsuruta, K. Shimizu, T. Dewa, M. Nango, N. Oku: RGD-based active targeting of novel polycation liposomes
bearing siRNA for cancer treatment. J. Control. Release, in press.
98. T. Yoshida, H. Kumagai, A. Suzuki, N. Kobayashi, S. Ohkawa, M. Odamaki, T. Kohsaka, T. Yamamoto, N. Ikegaya: Relaxin ameliorates
salt-sensitive hypertension and renal fibrosis. Nephrol Dial. Transplant, 27, Nov.15, 2011.
99. Y. Yoshinaga, K. Mochizuki, T. Goda: Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat
jejunum. Biochem. Biophys. Res. Commu. in press.
100. A. Yoto, S. Murao, M. Motoki, H. Yokogoshi: Oral intake of gamma-aminobutyric acid affects mood and activities of central nervous system
during stressed condition induced by mental tasks. Amino Acids, in press.

104

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事業推進担当者・若手研究者の研究業績（図書・総説）

事業推進担当者・若手研究者の研究業績（図書・総説）平成19年度（2007−2008年）

平成20年度（2008−2009年）

1. Y. Imai, T. Tanikawa, Y. Tobisawa, S. Narimatu, K. Kurohane, Y. Niwa, M. Shimizu, H. Kobayashi: Antibody and plantibody inducedby mucosal immunization for high profile food. Proceeding of The 2dn Symposium on Pharmaceutical Food Science, p. 83, 2007.
2. H. Kumagai: Nutritional therapy for patients undergoing hemodialysis. In “Nutrition and Kidney Disease” (H. Suzuki, and P.L. Kimmel,eds.), Karger, Basel. pp. 59-71, 2007.
3. M. Morita, T. Ohura, R. Kuruto-Niwa, H. Sakakibara, T. Amagai, K. Shimoi: Chlorinated phenanthrenes Induce CYP1A1 through arylhydrocarbon receptor activation. In “POPs in Asia”, 2008.
4. M. Nakayama, and N. Yoshimura: Skill development in a short-term English study abroad program. Selected Papers from the 2006
Annual Research Forum of the Linguistic Society of Hong Kong, pp. 55-66, 2008.
5. M. Nakayama, and N. Yoshimura: Oral presentation skills in short-term English study abroad programs.CD-ROM of the 25th
Conference of English Teaching and Learning in R.O.C. and 2008 International Conference on English Instruction and Assessment. pp.
1-18, 2008.
6. H. Ohshima, S. Tomono, Y-L. Lai, N. Miyoshi: Inflammation induced carcinogenesis and chemoprevention. In “Chemoprevention ofcancer and DNA damage by dietary factors” (S. Knasmüller, D.M. DeMarini, I.T. Johnson, and C. Gerhäuser eds.), Wiley-VCH Verlag
GmbH & Co. KGaA, Weinheim, 28, 191-198, 2008.
7. S. Onoue, S. Yamada, T. Yajima: Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for thetreatment of asthma/COPD. Peptides, 28, pp. 1640-1650, 2007.
8. Y. Suzuki: The highly pathogenic avian flu viruses and the molecular mechanism of the transmission of the viruses into humans.
Comprehensive Glycoscience from Chemistry to Systems Biology, Glycoconjugates and viral infections. Elsevier Publishing Book, Nov.
Issue, pp. 465-471, 2007.
9. T. Toyo'oka: Determination methods for biologically active compounds by ultra-performance liquid chromatography coupled withmass spectrometry: Application to the analyses of pharmaceuticals, foods, plants, environments, metabonomics and metabolomics.
J. Chromatogr. Sci. 46, pp. 233-247, 2008.
10. A. Takeda: Involvement of zinc in neuronal death in the hippocampus. Biomed. Res. Trace Elements, 18, pp. 204-210, 2007.
11. T. Urakami, and N. Oku: Current status of siRNA drug delivery technology and siRNA drug development. Open Drug Delivery Rev.
1, pp. 1-7, 2007.
12. 内田信也 , 山田静雄：食品・サプリメントと医薬品との相互作用 . ぶんせき 9, pp. 454-460, 2007.
13. 大島寛史 , 三好規之：がん予防『酸化ストレスの医学』，診断と治療社 2008.
14. 浅井知浩 , 米澤 正 , 奥 直人：腫瘍新生血管標的化リポソーム Mebio Oncology, 4, pp. 48-57, 2007.
15. 木苗直秀：食品と健康長寿 Food and Health Longevity, 薬学雑 , 127, pp. 399-406, 2007.
16. 木苗直秀 , 増田修一：Functional Food（共著）「糖尿病と機能性食品」
フジメディカル出版（2008）
17. 木苗直秀 , 増田修一：機能性食品の安全性ガイドブック（イソチオシアネート）㈱サイエンスフォーラム , pp. 223-227, 2007.
18. 木苗直秀 , 増田修一：機能性食品の科学（共著）「アブラナ科野菜の生理活性」, ㈱フジ・テクノシステム（2007）
19. 熊谷裕通：これからの管理栄養士のためのカルテの読み方〜検査値と数式の理解を中心に〜 カザン , 東京 . pp. 1-117, 2007.
20. 下位香代子：（ポリ）メトキシフラボノイドの多彩で有用な生理作用 FOOD Style 21, pp. 1150-51, 2007.
21. 下位香代子：10 有機酸−10.1 アミノ酸 , “機能性食品の辞典”, 朝倉書店 , pp. 182-187, 2007.
22. 鈴木 隆 , 高橋忠伸 , 左 一八：インフルエンザウイルス感染におけるスパイク糖タンパク質とシアロ複合糖質の役割 . 実験医学 波及・
深化する糖鎖研究 25（7）pp. 30-36, 2007.
23. 鈴木 隆 , 高橋忠伸 , 鈴木康夫：インフルエンザウイルス感染におけるスルファチドの機能 . 蛋白質核酸酵素（増刊号）「糖鎖情報の独自性と普遍性」（2007）
24. 鈴木康夫：高病原性 H5N1 鳥インフルエンザウイルスのヒトレセプター認識特異性変異 サーベイランスの必要性 BMSA 会誌 , 19
pp. 18-19, 2007.
25. 武田厚司：脳機能と微量元素 . Clinical Neuroscience, 25, pp. 868-869, 2007.
26. 山田康輔 , 熊谷裕通：栄養スクリーニング法 臨床透析 , 23, pp. 105-112, 2007.
27. 山田静雄 , 伊藤由彦：特集 --- 前立腺肥大症診療 Update--- 前立腺肥大症に対する補完代替療法の現状と将来 , Urology View, 5, pp.
44-50, 2007.
28. 山田静雄：高齢者の排尿障害とサプリメントの効果的な利用法 , 日本抗加齢医学会雑誌 , アンチ・エイジング医学（特集 エビデンス
サプリ）3, pp. 409-415, 2007.
29. 横越英彦 , 寺島健彦：第 8 章 8.3.2 その他の食品「メタボリック症候群と栄養」,（編者）, 幸書房 , pp. 160-175, 2007.
30. 横越英彦：「ストレスとＧＡＢＡ」（著者）、新静新書（静岡新聞社）, pp. 1-137, 2007.
31. 横越英彦：4.5 栄養「ストレスの科学と健康」,（分担）, 共立出版 , pp. 175-179, 2000.
32. 横越英彦：プロローグ メタボリック症候群の敬意と栄養学的アプローチ「メタボリック症候群と栄養」,（編者）, 幸書房、pp. 1-4, 2007.
33. 横越英彦：第 5 章 食品成分と脳機能の行動評価法「食品の生理機能評価法 〜実験系とツールの新展開を目指して〜」（責任編集）, 建
帛社 , pp. 99-114, 2007.
34. 横越英彦：第 8 章 8.1.1 メタボリック症候群と食品機能「メタボリック症候群と栄養」,（編者）, 幸書房 , pp. 137-140, 2007.
35. 藤野（隠岐）知美 , 山田静雄：機能性素材の安全性データ解析．複合成分・植物素材：ノコギリヤシの機能性および概要 . 機能性食品の安全性ガイドブック（津志田藤二郎 , 梅垣敬三 , 井上浩一 , 村上 明 編 , ㈱サイエンスフォーラム）, pp. 308-313, 2007.
36. 渡辺達夫：カプサイシン “抗肥満食品・素材の開発と応用展開­メタボリックシンドロームにおけるバイオマーカーの確立と応用”（大澤俊彦 監修） シーエムシー出版 , pp. 108-117, 2007.

1. T. Goda, Y. Kajiya, K. Suruga, H. Tagami: Estimation of metabolizable energy of resistant maltodextrin by indirect calorimetry in106healthy human subjects and experimental animals. In “Dietary Fiber – An International Perspective for Harmonization of Health Benefits
and Energy Values”,（D.T.Gordon, T. Goda, eds.）, AACC International, Inc., Minnesota, pp.123-134, 2008.
2. M. Isemura: Apoptosis-inducing activity of catechins. In “Beneficial Health Effects of Green Tea”, (M. Isemura, ed.), Recent Research
Developments in Phytochemistry Series, Research Signpost, Kerala, 2009.
3. M. Nakayama, N. Yoshimura: Skill development in a short-term English study abroad program. Selected papers from the 2006
Annual Research Forum of the Linguistic Society of Hong Kong. (C. Wong, ed.), Linguistic Society of Hong Kong, pp.55-66, 2008.
4. H. Ohshima, S. Tomono, Y.-L. Lai, N. Miyoshi: Inflammation Induced Carcinogenesis and Chemoprevention. In “Chemoprevention ofCancer and DNA Damage by Dietary Factors”, (S. Knasmüller, D. M. DeMarini, I. T. Johnson, C. Gerhäuser, eds.), WILEY-VCH Verlag
GmbH & Co. KGaA, Weinheim, 2009.
5. Y. Suzuki (Review): Developing an assay system for the hemagglutinin mutations responsible for the binding of highly pathogenic
avian influenza A viruses to human-type receptors. In “Experimental Glycoscience (Glycobiology)”, Springer, New York, pp.225-226,
2008.
6. Y. Suzuki, M. Sazuka, S. Isemura, M. Isemura: Interaction of green tea catechins with proteins. In “Beneficial Health Effects of GreenTea”. (M. Isemura, ed.), Recent Research Developments in Phytochemistry Series, Research Signpost, Kerala, 2009.
7. 大島寛史 , 三好規之 : がん予防 . 酸化ストレスの医学 , 診断と治療社 , pp.329-337, 2008.
8. 菅 敏幸 : エクチナサイジン 743 の合成 . 天然物化学−海洋生物編−, pp.264, 2008.
9. 木苗直秀 : 茶葉成分とメイラード反応縮合物の生成抑制効果 . Functional Food −機能性食品の基礎から臨床へ−, フジメディカル出
版 , pp.73-78, 2008.

10. 木苗直秀 , 増田修一 : 糖尿病と機能性 . Functional Food −機能性食品の基礎から臨床へ−, フジメディカル出版 , pp.12-16, 2008.
「ワサビの生理的効果」，「アブラナ科野菜の安全性」，「栄養11. 木苗直秀 , 増田修一 :「アブラナ科野菜（イソチオシアネートの生理活性）」，. 食品機能性の科学 . 株式会社産業技術サービスセンター , pp.252-266, 2008.
への影響」
12. 合田敏尚 : 栄養学̶健康から疾病まで . サプリメントアドバイザー必携 第 3 版（日本サプリメントアドバイザー認定機構編集）, 薬事日報社 , pp.34-56, 2008.
（第 3 版）, 朝倉書店 , pp.557-559, 2008.
13. 菅谷純子 , 三輪匡男 : 加水分解酵素 . 酵素ハンドブック（第 3 版）, 朝倉書店 , pp.832, 2008.
14. 菅谷純子 , 三輪匡男 : 加水分解酵素 . 酵素ハンドブック

15. 鈴木 隆 , 高橋忠伸 , 鈴木康夫 : 蛋白質 , 核酸 , 酵素 . インフルエンザウイルス感染におけるスルファチドの機能 , 共立出版 ,pp.1676-1682, 2008.
16. 武田厚司 : 亜鉛と脳機能 . 臨床検査 , Medical Finder, pp.197-201, 2009.
17. 横越英彦 : 栄養 . ストレスの科学と健康 , 共立出版 , pp.175-179, 2008.
18. 横越英彦 : ストレス軽減効果（テアニン）. 紅茶の保健機能と文化 , 株式会社アイ・ケイコーポレーション , pp.131-137, 2008.
19. 横越英彦 : 機能性素材としてのアミノ酸 , 3.γ- アミノ酪酸（GABA） ・テアニン . アミノ酸の科学と最新応用技術 , 株式会社シーエム
シー出版 , pp.246-254, 2008.

20. 横越英彦 : ストレスとアミノ酸の効果 . 脳と栄養ハンドブック , 株式会社サイエンスフォーラム , pp.269-275, 2008.
21. 横越英彦 : 代謝栄養学とは̶なぜ、食べなければならないの ? ネオエスカ「代謝栄養学」, 同文書院 , pp.1-4, 2008.
22. 横越英彦 : その他の体内代謝調節因子̶食事でガンや生活習慣病が防げるの ? ネオエスカ「代謝栄養学」. 同文書院 , pp.159-176,
2008.
23. 横越英彦 : 栄養と脳機能̶食べ物で頭がよくなるか ? ネオエスカ「代謝栄養学」, 同文書院 , pp.193-202, 2008.

107

事業推進担当者・若手研究者の研究業績（図書・総説）

事業推進担当者・若手研究者の研究業績（図書・総説）平成21年度（2009−2010年）

平成22年度（2010−2011年）

1. T. Asai, N. Oku: Angiogenic vessel-targeting DDS by liposomalized oligopetides. In “Liposomes: Methods and protocols” (V. Weissig

1. K. IP J. Hidari, T. Suzuki: Glycan receptor for influenza virus. Open Antimicobial Agents J. 2, 26-33, 2010.
2. K. I.P.J. Hidari, T. Suzuki: Structure and function of glycoconjugates involved in dengue virus infection. Seikagaku, 82, 751–755, 2010.
3. T. Higashi, K. Shimada, T. Toyoʼoka: Advances in determination of vitamin D related compounds in biological samples using liquid
chromatography–mass spectrometry: A review. J. Chromatogr. B, 878, 1654-1661, 2010.
4. H. Ohshima, S. Tomono, Y-L Lai, N. Miyoshi: Inflammation Induced Carcinogenesis and Chemoprevention. In: Knasmüller, S.
DeMarini, D.M., Johnson, I.T. & Gerhäuser, C. eds.: Chemoprevention of Cancer and DNA Damage by Dietary Factors,
2009.WILEY-VCH Verlag GmbH & Co. KGaA.
5. M. Shimizu, K. Kawai, K. Kaku, T. Shimizu, H. Kobayashi: Application of mutated acetolactate synthase genes for herbicide resistanceto plant improvement. In "Herbicides, Theory and Applications" (S. Soloneski, and M. L. Larramendy, eds.), InTech, pp. 193-212(2011)
6. A. Takeda: Zinc signaling in the hippocampus and its relation to pathogenesis of depression. Mol. Neurobiol., DOI:
10.1007/s12035-010-8158-9, 2011.
7. A. Takeda: Insight into glutamate excitotoxicity from synaptic zinc homeostasis. Int. J. Alzheimers Dis. 2011, 491597, 2011.
8. A. Takeda and H. Tamano: Insight into neurozinc in the hippocampus. Biomed. Res. Trace Elements, 2011.
9. A. Takeda and H. Tamano: Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances. J. Neurosci. Res.
88, 3002-3010, 2010.
10. H. Tamano and A. Takeda: Dynamic action of neurometals at the synapse. Metallomics, DOI: 10.1039/c1mt00008j, 2011.
11. T. Watanabe, Y. Iwasaki, A. Morita, K. Kobata: Food components activating capsaicin receptor TRPV1, in “Nutrigenomics andProteomics in Health and Disease” : Food Factors and Gene Interactions.” ed. by Mine Y, Miyashita K, and Shahidi F, Wiley-Blackwell,pp. 263-272, 2010.
12. H. Yokogoshi: Sense of taste and brain: nutritional neurosciences viewed from five senses〜Research of dietary constituent andfunctional evaluation as food〜 Human volunteer examination from test on animals. Journal for the Integrated Study of Dietary Habits,
Vol.20, No.4, pp.270-274 (2010)
13. A. Yoshida, T. Fujino, S. Maruyama, Y. Ito, Y. Taki, S. Yamada: The forefront for novel therapeutic agents based on thepathophysiology of lower urinary tract dysfunction: Bladder selectivity based on in vivo drug-receptor binding characteristics ofantimuscarinic agents for treatment of overactive bladder. J. Pharmacol. Sci., 112: 142-150, 2010.
14. 石井 剛志、菅 敏幸 : お茶の効能を分子レベルで解明する , ファルマシア 46, 1143-1148, 2001.
15. 下位香代子 , 榊原啓之 : 各種変異原性からみた食品関連の有機化学物質（第 8 章 有害化学物質による汚染−8.1）食品に関して知っ, 食品安全ハンドブック編集委員会編 , 丸善（東京）, 2010.
ておくべき衛生安全知識のすべて『食品安全ハンドブック』
16. 鈴木 隆：抗インフルエンザ薬について . 実験治療 , 699, 48-54, 2010.
17. 鈴木 隆、鈴木康夫：インフルエンザウイルス感染の化学的理解に向けて−宿主細胞からの放出− 現代化学 , 476, 45-50, 東京化学同
人 , 2010.
18. 高橋忠伸、鈴木 隆：スルファチドによるインフルエンザ A 型ウイルス増殖の促進 . Glycoforum, SEIKAGAKU CORPORATION, 2010.
19. 武田厚司：亜鉛と健康 . 健康食品管理士認定協会会報 , 5, 9-13, 2010.
20. 藤野知美 , 伊藤由彦 , 瀧 優子 , 柿澤希実 , 尾上誠良 , 今井康之 , 奥 直人 , 野口博司 , 伊藤邦彦 , 小林裕和 , 大橋典男 , 合田敏尚 , 木苗直秀 , 梅垣敬三 , 渡邉裕司 , 山田靜雄 : Warfarin とビタミン K の相互作用に関する文献的研究 . 臨床薬理 , 41, 43-52, 2010.
21. 陽東藍 , 横越英彦：GABA 茶の抗ストレス効果機能「ニューフードインダストリー」, 食品資材研究会 , New Food Industry, Vol.52,
No.3, pp7-12, 2010.
22 横越英彦：脳機能に影響を与える食品成分 今後の「食」を探る 「, 乳酸菌ニュース」社団法人全国はっ酵乳乳酸菌飲料協会 , pp21-24,
2010.
23. 横越英彦：GABA−脳神経系への影響「Functional Food」9 号 −機能性食品の基礎から臨床へ−, 特集 : 認知症と機能性食品 , フジ
メディカル出版（大阪）, Vol.3, No.3, pp.226-231 2010.
24. 横越英彦：テアニン−緑茶に含まれるテアニンの脳神経系への影響「Functional Food」9 号−機能性食品の基礎から臨床へ−, 特集 :認知症と機能性食品 , フジメディカル出版（大阪）, Vol.3, No.3, pp.238-243 2010.
25. 横越英彦：食品成分の研究と食品としての機能評価〜動物実験からヒトボランティア試験まで〜 特集 : 機能性食品の開発と展望 , ケ
ミカルエンジニアリング , 化学工業社 , vol.55, No.4, pp.13-17, 2010.
26. 橫越英彦：チョコを食べて勉強しよう 超はかどり技 3 食べ物ではかどる !, ベネッセコーポレーション（東京）, p.10-11 2010.
27. 横越英彦：朝ティー習慣をはじめよう !, 株式会社角川 SS コミュニケーションズ（東京）, Vol.709, p.55-56, 2010.
28. 横越英彦：朝ティー習慣をはじめよう !, ORANGE PAGE（東京）, p.120-121, 2010.
29. 横越英彦：タンパク質・アミノ酸・炭水化物類 −５: GABA. 食品シリーズ「食品機能素材 IV」, シーエムシー出版（東京）, pp.165-168,2010.
30. 横越英彦：味と脳の感覚「五感からみた栄養神経科学 食品成分の研究と食品としての機能評価〜動物実験からヒトボランティア試験, 日本食生活学会誌 , vol.20, No.4, pp.270-274, 2010.
〜」31. 橫越英彦：脳の機能と栄養心と栄養を包括する科学 . Journal of Health Sciences of Mind and Body, 6（1）, pp.6-12, 2010.
32. 橫越英彦：お砂糖豆知識−甘いおやつの効用「砂糖類情報」, 独立行政法人農畜産業振興機構、砂糖類情報 7（No.166）、pp.38-40,
2010.

ed.), Humana Press Springer, N.Y., Vol.1, pp335-347, 2010.
2. H. Ohshima, S. Tomono, Y.-L. Lai, N. Miyoshi: Inflammation Induced Carcinogenesis and Chemoprevention. In “Chemoprevention ofCancer and DNA Damage by Dietary Factors” , (S. Knasmüller, D. M. DeMarini, I. T. Johnson, C. Gerhäuser, eds.), WILEY-VCH Verlag
GmbH & Co. KGaA (WILEY-VCH), Weinheim, pp145-152, 2009.
3. N. Oku, T. Ishii.: Antiangiogenic Photodynamic Therapy with Targeted Liposomes. In “Methods in Enzymology” (N. Duzgunes ed.),Vol. 465, pp313-330, 2009.
4. T. Sawada, T. Hashimoto, H. Tokiwa, T. Suzuki, H. Nakano, H. Ishida, M. Kiso, Y. Suzuki: How does the FMO method help instudying viruses and their binding to receptors ?, (D. G. Fedorov, K. Kitaura, eds.) The Fragment Molecular Orbital Method, CRC
press, Boca Raton, chapter 9 pp193-215, 2009.
5. M. Suzuki, Y. Ito, T. Fujino, M. Abe, K. Umegaki, S. Onoue, H. Noguchi, S. Yamada: Pharmacological effects of saw palmetto extract
in lower urinary tract. (Invited review). Acta Pharmacol Sin, 30, pp271-281, 2009.
6. Y. Suzuki: The Highly Pathogenic Avian Influenza H5N1 - Initial Molecular Signals for Next influenza Pandemic-. Chang Gung Med. J.,
32, pp258-263, 2009.
7. T. Takahashi, T. Suzuki: Role of sulfatide in virus infection and replication. In “ TRENDS IN GLYCOSCIENCE AND
GLYCOTECHNOLOGY (TIGG)”, Official Journal of the Japanese Society of Carbohydrate Research, Tokyo, Vol. 21, No. 121, 2010.
8. T. Takahashi, T. Suzuki: Role of membrane rafts in viral infection. In “BENTAM OPEN” , The Open Dermatology Journal, Illinois, Vol.
3, pp178-194, 2009.
9. A. Takeda, H. Tamano: Insight into zinc signaling from dietary zinc deficiency. Brain Res. Rev.,San Diego, 62, pp33-44, 2009.
10. T. Watanabe, Y. Iwasaki, A. Morita, K. Kobata: Food components activating capsaicin receptor TRPV1. In “Nutrigenomics andProteomics in Health and Disease: Food Factors and Gene Interactions” (Y. Mine, K. Miyashita, F. Shahidi, eds.), Wiley-Blackwell, New
Jersey, pp263-272, 2009.
11. 大川栄重 , 熊谷裕通： CKD 患者の輸液と経腸栄養の指針（腎不全患者向けの経口および経静脈アミノ酸輸液の現状と課題）. 臨床透
東京，Vol.25, pp77-83, 2009.
析 , 日本メディカルセンター，

12. 熊谷裕通： CKD と栄養・食事管理（腎不全・透析患者の栄養障害とアセスメント）. 臨床栄養 , 医歯薬出版 , 東京 , Vol.115,
pp429-432, 2009.
13. 合田敏尚 , 豊岡利正 , 小林公子 , 内藤祐二 , 大澤俊彦 , 福岡秀興 , 平岡真実 , 武田英二：（合田敏尚 ) 個人対応栄養学の潮流，ニュー,
個人対応栄養指標確立に向けたメタボリックプロファイリング
トリゲノミクスのヒトへの応用戦略，個人対応栄養学の展望（豊岡利正）,
人類遺伝学からみた個人対応栄養学の基盤 [ テーラーメイド個人対応栄養学 （合田敏尚], 岡崎光子法の重要性と可能性（小林公子）
編）, 日本栄養・食糧学会監修，建帛社，東京，2009.
（共著（独）:
科学技術振興機構）pp142-148, 2010.
14. 鈴木 隆 : インフルエンザの治療薬と糖鎖 . 糖鎖を知る

15. 鈴木康夫：パンデミック（H1N1）2009 ウイルスとマクロライド系薬の有効性 . 新薬と臨床 , 医薬情報研究所，東京，59（1）, pp13-21,
2010.
16. 高橋忠伸 , 鈴木 隆 : パンデミックインフルエンザウイルスの出現とノイラミニダーゼの酸性安定性 -Emergence of pandemic influenza
viruses and low-pH stability of neuraminidase- THE LUNG perspectives, 株 式 会 社 メディカルレビュー 社 , 東 京 , Vol. 17 No. 4,
pp83-88, 2009.
17. 武田厚司： 海馬グルタミン酸作動性神経に対する抑肝散の作用 . 脳 21, 金芳堂，京都，12, pp20-23, 2009.
18. 武田厚司： 亜鉛と脳機能 . 臨床検査 , 医学書院 , 東京，53, pp197-201, 2009.
19. 中山峰治 , 吉村紀子 : 英語力の向上に役立つ海外研修とは . [ 英語教育 ], 大修館書店，東京，57（13）, pp50-53, 2009.
20. 藤野知美 , 木苗直秀 , 山田静雄： 健康食品・サプリメントと医薬品との相互作用．
ミネラルとの相互作用．Functional Food, フジメディ, pp431-440, 2009.
カル出版，大阪，2（4）.
高齢者時代に向けた食の対応）,（社）農林水産技術情報協会 ,21. 横越英彦 , 源川博久：食事による高齢者の脳機能の健全性維持（特集
農林水産技術研究ジャーナル , 東京 , Vol.32, No.5, pp29-33, 2009.

22. 吉村紀子 , 中山峰治 : 海外短期英語研修と第２言語習得 . ひつじ書房 , 東京 , 2010.
23. 渡辺達夫：エネルギー消費を高める食品成分 . Food Research, 8, pp42-46, 2009.
24. 渡辺達夫：辛味関連化合物とエネルギー消費 . 食品加工技術 , 29（4）, pp27-33, 2009.

108

109

事業推進担当者・若手研究者の研究業績（図書・総説）

産経新聞

平成23年度（2011−2012年）

1. T. Dewa, T. Asai, N. Oku, M. Nango: Polyamine-Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, andGene Transfer Activity. In “Non-Viral Gene Therapy” (X-B Yuan ed.), In Tech, pp.243-266, 2011.
2. K.I.P.J. Hidari and T. Suzuki: Dengue virus receptor. In “Trop. Med. Health”, in press.
3. K.I.P.J. Hidari and T. Suzuki: Antiviral agents targeting glycans on dengue virus E-glycoprotein. In “Expert. Rev. Anti. Infect. Ther.” 9,
983-985, 2011.
4. S. Inagaki and T. Toyoʼ oka: Amino acid analysis via LC-MS method after derivatization with quaternary phosphonium. In “Amino Acid
Analysis: Methods and Protocols, Methods in Molecular Biology” , (M.A. Alterman and P. Hunziker eds.), Humana Press, 828, 47-54,
2012.
5. K. Shimizu and N. Oku: Brain Tumor Diagnosis Using PET with Angiogenic Vessel-Targeting Liposomes. In “Tumors of the Centra
Nervous System”, (M.A. Hayat ed.), Springer, 3, pp.169-176, 2011.
6. K. Shimoi and T. Shibuya: Introduction to the special issue on epigenetics. In “Genes and Environ.” , Science for Genome Safety, 33(2),pp.33, 2011.
7. J. Sugatani and M. Miwa: Transcriptional regulation of human bilirubin: UDP-glucuronosyltransferase UGT1A1 gene and implicationof defects in the UGT1A1 gene promoter. In “Bilirubin: Chemistry, Regulation and Disorder” . (J. F. Novotny and F. Sedlacek eds.)
NOVA Science Publishers (2011) in press.
8. Y. Suzuki (Review): Avian and human influenza virus receptors and their distribution. In “The molecular immunology and complex
carbohydrates-3 Advances in Experimental Medicine and Biology”, (A.M. Wu ed.), Springer, 705, pp443-452, 2011.
9. Y. Suzuki (Review): Highly pathogenic avian influenza. In “Journal of Disaster Research” , (S. Murakami and K. Takaguchi eds.), FUJI
TECHNOLOGY PRESS, 6(4), 398-403, 2011.
10. T. Takahashi, T. Suzuki.: Function of membrane rafts in viral lifecycles and host cellular response. In “ Biochemistry ResearchInternational”, (B.P. Head ed.), Hindawi Publishing, Article ID: 245090, 2011.
11. A. Takeda: Zinc signaling in the hippocampus and its relation to pathogenesis of depression. In “Mol. Neurobiol.” , (N.G. Bazan ed.),Springer, 44, 166-174, 2011.
12. A. Takeda: Insight into glutamate excitotoxicity from synaptic zinc homeostasis. In “Int. J. Alzheimerʼ s Dis.” , (A.R. White ed.), Hindawi
Publishing, Article ID: 491597, 2011.
13. H. Tamano and A. Takeda: Dynamic action of neurometals at the synapse. In “Metallomics”, RSC Pub., 3, 656-661, 2011.
14. T. Wakimoto, T. Asakawa, S. Akahoshi, T. Suzuki, K. Nagai, H. Kawagishi, T. Kan: Proof the existence of an unstable amino acid,pleurocybellaziridine, in “Pleurocybella porrigens (angelʼ s wing mushroom)”. In “Angew. Chem. Int. Ed.” , Wiley-VCH, 50, 1168-1170,
2011.
15. Y. Watanabe, M.S. Ibrahim, Y. Suzuki, K. Ikuta (Review): Avian Influenza A virus (H5N1): the changing nature. In “ Trends in
Microbiology”, Cell Press, 20, 11-20, 2012.
16. S. Yamada, Y. Ito, H. Tsukada: α1 -Adrenoceptors and muscarinic receptors in voiding function - Binding characteristics oftherapeutic agents in relation to the pharmacokinetics. In “Br J Clin Pharmacol.”, Wiley-VCH, 72, 205-217, 2011.
17. S. Yamada and Y. Ito: α1-Adrenoceptors in the urinary tract. In “Urinary tract (Handbook of Experimental Pharmacology)” , (K.E.
Andersson, M.C. Michel eds.), Springer, 202, pp.283-306, 2011.
18. P. Hawke and R. Whittier: 日本人研究者のための絶対できる英語プレゼンテーション [Presentation Skills for Japanese Scientists]. 羊
土社 , 2011.
19. 伊勢村護 : 抹茶の効用 / 活用法 . サライの「茶の湯」大全 , 小学館 , pp.112, 2011.
20. 菅敏幸 , 林雄二郎： 天然物の全合成で活躍した反応 - 実験のコツとポイント -. 有機合成協会 , 化学同人 , 2011.
21. 菅敏幸 : 効率的へテロ環構築を基盤とする生理活性天然物の合成 . 化学工業 , 62, pp.615-620, 2011.
22. 熊谷裕通：慢性腎臓病における骨格筋減少のメカニズム , 臨床透析 , 27, pp.1299-1304, 2011.
23. 熊谷裕通： 透析治療についてこれだけは知っておこう−輸液はどうする？−, “若手医師のための透析診療のコツ” ( 加藤明彦編 ), 文光
堂 , pp69-73, 2011.
24. 熊谷裕通： 浮腫がある患者の栄養アセスメント −浮腫の栄養ケア アセスメント：水・電解質管理、栄養管理はどうすればよいか−,
臨床栄養 , 118, pp.258-262, 2011.
25. 榊原啓之 , 小柳顯陽 , 青島良輝 , 鈴木敬明 , 木村昌由美 , 下位香代子： 外部刺激に対する生体応答を評価するために−夜行性のマウスを用いた時間生物学的アプローチ−. 谷本学校毒性質問箱 , 株式会社サイエンティスト社 ,13, pp.116-123, 2011.
26. 鈴木康夫：シアル酸で決まるインフルエンザの流行 . グライコフォーラム , 2011.
27. 鈴木康夫： 注目されるウイルス感染症と制御対策 −薬剤による制御対策−. 日本防菌防黴学会誌 , 防菌防黴 , 39 pp.641-652, 2011.
28. 武田厚司 : ニューロジンクから視た脳機能 . ファルマシア , in press.
29. 山田康輔 , 熊谷裕通： 栄養スクリーニング法 . 腎不全医療における栄養管理の基礎知識 , ( 加藤明彦 , 市川和子編 ), 日本メディカルセンター , pp.63-70, 2011.
30. 山田静雄：ミニレビュー「ノコギリヤシ」, New Diet Therapy, 日本臨床栄養協会 , 27, pp.35-39, 2011.
31. 吉田卓矢 , 熊谷裕通： 食事制限で低栄養になる：そうか、そういうことだったのか！透析患者のからだのヒミツ 20. 透析ケア , 17,
pp.676-677, 2011.
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