2023 Corporate
Sustainability ReportWho We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

PTC’s commitment to corporate
responsibility focuses on five key pillars:

OurPatients

PTC Therapeutics 2023 Corporate Sustainability Report

Our
PeopleOur
Community

Our
Environment

Our
Values2

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Table of Contents
Who we are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Global Footprint

Empowering Patients

Employee Benefits

Global OutreachGreen Operations

Compliance Program

Our Science

Supporting the Rare
Disease Community

Learning &Development

Empowering Future
STEM Leaders

Sustainability Efforts

Privacy Policies &Cybersecurity

Patient Resources

PTC Culture

FIPFA Powerchair Football
World Cup 2023

Global Equality,
Diversity & Inclusion

Community Needs &Volunteer Efforts

Our PipelineAwards & Recognition

PTC Therapeutics 2023 Corporate Sustainability Report

Board of Directors

3Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

A Message from our CEO
2023 was a transformational year for PTC. As PTC celebrated
its 25th anniversary, it was a perfect time to reflect on thecompany’s many pioneering and impactful contributions
and make important changes so that we could mature into aleaner, stronger and well-capitalized PTC positioned for future
success. In building the PTC of the future we emphasized focus
and continue to take our obligations related to environmental
stewardship, social responsibility and corporate governanceseriously. One thing that hasn’t changed is our mission.
We remain a patient-focused company that will continue
a legacy of discovering, developing and commercializing
transformative therapies for patients with rare diseases.
Matthew B. Klein, M.D., M.S., FACS
Chief Executive Officer

PTC Therapeutics 2023 Corporate Sustainability Report4Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Who We Are
PTC Therapeutics 2023 Corporate Sustainability Report5Who We Are

PTC is a global
biopharmaceuticalcompany focusedon the discovery,
development andcommercializationof clinicallydifferentiatedmedicines thatprovide benefits topatients with rare
disorders.

PTC Therapeutics 2023 Corporate Sustainability Report

Patients

PeopleCommunity

Environment

Ethics & Complianceglobalofficelocations

PTC’s goal is to provide access to best-in-class treatments for patients who have little to notreatment options. Our strategy is to leverage our strong scientific and clinical expertise andglobal commercial infrastructure to bring therapies to patients.

6

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Our Science
Our research efforts are focused on two scientific platforms—splicing and ferroptosis
and inflammation—where PTC has unique expertise to discover and advance innovative
therapies to the clinic.

Splicing
Platform

PTC Therapeutics 2023 Corporate Sustainability Report

Ferroptosis andInflammation Platform

7

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Our Pipeline
We have a robust development
portfolio with a number of potentiallypromising therapies for rareneurologic and metabolic diseases
including PKU, HD and ALS.

Commerical Products

Development
Sepiapterin (PKU)

Phase 1

Phase 2Phase 3

NDA Stage

Vatiquinone (FA)Phase 1

Phase 2Phase 3

NDA Stage

Utreloxastat (ALS)

Phase 1

Phase 2

PTC518 (HD)Phase 1

Phase 2

Undisclosed (Myopathies)

Phase 1

Research

Splicing Platform
SCA-3
MAP-tau
Undisclosed(Movement Disorders)

PTC Therapeutics 2023 Corporate Sustainability Report

PKU, phenylketonuria; FA, Friedreich ataxia; ALS, amyotrophic lateral sclerosis; HD, Huntington‘s disease

Ferroptosis and Inﬂammation Platform
Undisclosed(Neurodegenerative Diseases)
Undisclosed(Pediatric Neurodevelopment Disorders)8Who We Are

Patients

PeopleCommunity

Environment

Ethics & ComplianceAwards and Recognition
In 2023, PTC was recognized across a variety of categories for awards in scientific innovation,commitment to employees and disease awareness.

Commitment to Employees: Highlighting Culture and Diversity
PTC’s commitment to employees was demonstrated though the several awards won around the globe in categories
including learning and development, diversity and inclusion, and talent acquisition.
º 2023 Don Clifton Strengths-Based Culture Awardº PTC Global HR team: Irish HR Champion in the “Learning & Development
Strategy” category at the 2023 Irish HR Champion Awardsº PTC in Brazil: Great Place to Workº MAGIC Employee Resource Group: 2023 Top Diversity Company Award;
Intrama’s Diversity and Inclusion Summit in Madridº Talent Pipeline Program: TIARA Talent Acquisition Awards: The Avenica Early Careers Pioneer Awardº Kylie O’Keefe , our Chief Commercial Officer, was recognized by the Healthcare
Businesswomen’s Association (HBA) as a Luminary award winnerº Executive Women of New Jersey’s Business Honor Roll: 2023 Corporate Board Gender Diversity Awards

PTC Therapeutics 2023 Corporate Sustainability Report9Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

A Global Culture of Innovation
PTC’s culture of innovation was recognized in several
honors awarded in Europe in 2023.
º EURORDIS Black Pearl Award: “Company
Award for Innovation”º PTC in Italy:• Le Fonti Award for Excellence in BiopharmaceuticalInnovation & Leadership of the Year
• The Excellence of Scientific Informationand the Centrality of the Patient Awardº PTC in Ireland: Life Sciences Industry Awards
Ireland – Supply Chain Achievementº Prix Galien UK, France, Germany Awards: PTC was
selected as a finalist in the prestigious 2023 Prix
Galien Award program for “Best Pharmaceutical
Product” for the development of Upstaza in the UK
and in the Orphan Drug Category in Germany

PTC Therapeutics 2023 Corporate Sustainability Report10Who We Are

Patients

PeopleCommunity

Environment

Ethics & ComplianceDisease Awareness:
Spotlight on Latin America
PTC in Brazil took home several awards for their creativeand impactful projects supporting the rare diseasecommunity.
º National phase of the 2023 Aberje Award in themulti-public category for Mocotó SQF. Aberje is theBrazilian Association of Corporate Communicationsº SABRE América Latina 2023 Award for“Living is Rare” documentary seriesº 47th Lupa de Ouro Awards 2023 for “Best
Project – Digital Marketing Focus on Process
and Culture Transformation” for the initiative“Detetive Gui” (Detective Gui), to raiseawareness awareness about Duchenne
PTC in Brazil was also a finalist in the 47th Lupa de OuroAwards 2023 in the “Best Medical Area Project” Category:º Third place for “Livro de Receitas Descobrindo Novos
Sabores” (Recipe Book Discovering New Flavors)º Fourth place with “Molécula doConhecimento” (Knowledge Molecule)

Spotlight on Mocotó SQF
To raise awareness of the familial
chylomicronemia syndrome (FCS) andsupport the FCS community, PTC, FCS
patient advocacy organizations, Mocotó,
an award-winning restaurant, and thehealthcare communications consultancy
LLYC Brazil collaborated to create Mocotó
SQF, a restaurant tailored to people livingwith FCS. The goal was to create a unique,memorable and safe experience for thoseliving with FCS, so that for the first time intheir lives, they could eat safely away from
home, without fear.
(“SQF” is an abbreviation in Portuguese for FCS)PTC Therapeutics 2023 Corporate Sustainability Report11Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Patients
PTC Therapeutics 2023 Corporate Sustainability Report12Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

We are deeply committed to children
and adults living with rare diseases who
have little to no treatment options.
We work hard to provide resources
and support to patients and theirfamilies through compassionate
collaboration, throughout the
drug development process.
We strive to ensure we deeply
understand a patient’s disease journey
and involve them every step of the way– from early research and development,
to clinical trials, to commercializationand support programs.

PTC Therapeutics 2023 Corporate Sustainability Report

We partner with more than 200 patient advocacy
organizations (PAOs) across the globe, and we cherish
the relationships we forge and maintain with them.

13

Who We Are

Empowering
Patients
Empowering the rare diseasecommunity and elevating their voices
is critical to raising awareness of rarediseases around the world. Several of
our programs focus on this goal.

Patients

PeopleCommunity

Environment

Ethics & Compliance

Kevin Alexander lives withphenylketonuria (PKU) and has
been an advocate for PKU,
newborn screening and raredisease awareness for overa decade. Kevin started byproducing the video “My PKU Life”
and has since traveled around theworld speaking about life with thisrare disease and producing othervideos about PKU. He contributed
an article to help spread awarenessabout PKU:

 Owning Your Rare Disease Story

Kevin Alexander, VP, Louisiana Metabolic Disorders Coalition; volunteer,
National PKU Alliance; member of the International Society for Neonatal Screening.
PTC Therapeutics 2023 Corporate Sustainability Report14

Who We Are#DuchenneCan

Witnessing firsthandwhat people with
Duchenne muscular
dystrophy CAN do
inspired the creationof #DuchenneCan in
2021. This global social
media movement
celebrates remarkable
individuals in the
Duchenne community,
the people who loveand care for them andthe groups dedicatedto supporting them.

PTC Therapeutics 2023 Corporate Sustainability Report

My VIBE Podcast“My VIBE: My Voice isInspirational, Braveand Empowering”
gives patients,
caregivers, families
and friends a forum toshare their story andjourney living with arare disease. The goal
is for the community
to hear directly fromthe person affectedby rare disease, andfor the person toknow that their voice
is important.

Patients

PeopleCommunity

Environment

Ethics & ComplianceTake on Duchenne
North America Podcast“Share Your Story”
Features

Each episodebrings scientificleaders in the field ofDuchenne together
to discuss and shareknowledge, insights
and perspectives tosupport the continuous
education andawareness of this disease
among healthcarecommunity and thoseinterested to learn more
about Duchenne.

We encourage
people in the raredisease community
to contribute to our“Share Your Story”
news feature on the
PTC website. The
stories are written bypatients to showcase
their firsthandexperiences in theirrare disease journey.

Rare Talks:
AADC Podcast

The Rare Talks: AADC
Podcast is a series
focused on AADC
deficiency awarenessand information, withepisodes aimed athealthcare professionals,
patients and caregivers.
Guests include leading
experts to discuss
key AADC deficiency
topics, from signs andsymptoms to navigating
the appropriate tests toconfirm a diagnosis.

15

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

PTC employees participate in many activities to support
the rare disease communities we serve.
Cycling for DE Duchenne 40

PTC employees in Northern Europe cycled 40km in June to raise money
and awareness for Duchenne. The initiative supported “De Duchenne 40”,organized by Duchenne Parent Project Netherlands, to further researchand better care for young adults with Duchenne to help them live to be atleast 40 years old.

Run4Duchenne

PTC colleagues in Switzerland participated in the annual Christmas
Run, “Zürcher Silvesterlauf”, and joined the Run4Duchenne charity
run. This event was organized by Duchenne Schweiz Associationand the Swiss Muscle Society (Schweizerische Muskelgesellschaft).

PTC Therapeutics 2023 Corporate Sustainability Report16

Who We Are

RideATAXIA

PTC showed commitment
to the Friedreich ataxia(FA) community by cosponsoring the 2023
rideAtaxia annual bikeride. Colleagues in the
N.J. area gathered to ride
up to 50 miles (80.47km)
to raise awareness andadvocate for advancing
research to treat andcure FA.

PTC Therapeutics 2023 Corporate Sustainability Report

Patients

PeopleUniversidad de La
Sabana and PTC Partner
to Provide Training for
Patient Associations

Physiotherapy
and Rehabilitation
Training on Duchenne
Held in Turkey

PTC in Colombia, inpartnership with the
Universidad de La Sabana,offered a comprehensive
learning experiencefor 20 PAOs from the
SAM region through a
training titled, “Corporate
Communications
and Organizational
Assertiveness: The
Basics of Leadership.”The 56‑hour course
centered on effective
communication practices.

PTC supported theEuropean Alliance of
Neuromuscular Disease
Associations, a patientumbrella association,in Physiotherapy
and Rehabilitation
Training in cooperation
with İstanbul Galata
University. The
training was done incollaboration with local
PAOs, and more than
50 physiotherapists
attended the event.

Community

Environment

Ethics & Compliance17

Who We Are

Living with a rare disease or caring forsomeone with a rare disease comeswith many challenges. In addition toprocessing new and complicatedinformation and making countlessdecisions, it can be tough to know where
to turn to for help, or where to even begin.
At PTC, we develop and provide
resources to support patients andcaregivers, with the goal of increasing
disease awareness and understanding
both for those with a diagnosis and for
those who are searching for an answer.

PTC Therapeutics 2023 Corporate Sustainability Report

Patients

PeopleGlobal Patient
Engagement(PE) TeamWe have dedicatedPE teams covering theU.S., Latin America and
EMEA (Europe, Middle
East and Africa). The PEteam is an incredibly
important function of
PTC, as they act as adirect line of contact,building relationships
between the company
and rare disease patients,
caregivers and PAOs.
They ensure the patient’s
voice is incorporated
in all aspects of drug
development.

Community

Environment

Ethics & Compliance

PTC Cares

Genetic Testing

In the U.S., the PTC Cares
program helps take care oftreatment coordination, so
patients with a rare disease
and their families can spend
more time taking care ofthemselves. DedicatedCase Managers support
families throughout therare disease journey andprovide the expertiseneeded to help makethe process of getting
treatment easier.

We partner withmultiple companies
to provide freegenetic testing tohelp decrease time
to diagnosis.

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Who We Are

Patients

PTC was a proud sponsor for
the FIPFA Powerchair Football
World Cup 2023, organizedby Fédération Internationale
de Powerchair Football
Association (FIPFA). This premier
event of global powerchair
football excellence, played in
30 nations across Europe, theAmericas and the Asia-Pacificregion, showcases the highest
level of competition, uniting
teams from diverse nations
and providing a platform forplayers with varying abilities todemonstrate their skills.
The Powerchair Football World
Cup 2023 was an inspiring
event, furthering the progressof people with disabilities andempowering the community toachieve extraordinary things on
and off the field.

PTC Therapeutics 2023 Corporate Sustainability Report

PeopleCommunity

Environment

Ethics & Compliance

FIPFA Powerchair Football World Cup 2023
October 2023 | Sydney Olympic Park, Australia

10 nations represented

Players with diverse abilities, including those with Duchenne,
cerebral palsy, spinal muscular atrophy, different syndromes
and severe handicaps.

“ eople with rare diseases and disabilities
P
possess many qualities, attributes andcapabilities that define the person’s identityand potential. That is how people in thecommunity should be recognized – rather
than by disability. At PTC, we believe everyone
should have equal access to participate in lifeand pursue their potential.

Sarah Bourgeois
VP, Head of Global Marketing“ thletic achievements by people withA
disabilities are parallel to any other major sport
and top athlete. The more we can support thisdevelopment the more the sport can grow andreceive recognition.

Nikhil Jayaram
VP and General Manager, APAC

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Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

PeoplePTC Therapeutics 2023 Corporate Sustainability Report20

Who We Are

At PTC, we invest
in our people
and dedicate
resources todevelopment andlearning, ensuring
our employees
are supported andempowered in theircareers. We strive
to grow a pool ofdiverse leaders andfocus on continued
leadershipdevelopment.

PTC Therapeutics 2023 Corporate Sustainability Report“

Patients

People esearch consistently showsR
that a key engagement
element for employees
is that they feel they
are developing in theirrole. We help make thispossible by providing avariety of programs and toolsthat support employees andleaders in their careers.
Hege Sollie-Zetlmayer
SVP, Human Resources

Our deep passion for patients drives us
to think differently about solutions andto work collaboratively as One PTC. We
are grounded by our PTC Expectations,which guide the core values, work principles
and behaviors that define the culture andbring the idea of a “One PTC” team to life.

Community

Environment

Ever Better

Be Kind

Ethics & Compliance

Passionate
About Purpose

Work asOne PTC

Think like an
Entrepreneur

Champion
Inclusion,
Trust & Respect

Be Bold21

Who We Are

Patients

PeopleCommunity

Employee Benefits
PTC offers a wide variety of benefit options to meet the diverse needs of our employees globally. We arecommitted to ensuring that our benefits program offers meaningful choices plus valuable resources tosupport the moments that matter most. Our comprehensive benefits in the U.S. include:• Medical, dental and vision insurance• Dependent and health flexible spending accounts• Health savings accounts with company contributions• Retirement plan with company match• Income protection including life and disability• Employee stock purchase plan
• Company-wide equity awards• Family planning benefits and child bonding benefits• Tuition reimbursement

PTC Therapeutics 2023 Corporate Sustainability Report• Work-life balance measures(i.e., remote work/schedule flexibility)• Time-off programs• Peer recognition program• Global wellbeing program

Environment

Ethics & Compliance

PTC’s Employee Relief Fund (ERF)
The PTC ERF is a global non-profit charitable
fund designed to help employees facing
financial hardship with a tax-qualified grant intheir time of need, whether it’s immediately
after a natural disaster or due to unforeseen
personal adversity. The ERF relies primarily
on individual donations from employees.

In 2023:
The ERF received more than
$25,000 in donations• Family caregiver support and parental success program• Global employee assistance program• Employee health advocacy program
Outside of the U.S., we also offer many of these benefits,
as well as others consistent with local expectations for ourindustry in addition to applicable legal requirements.

$4,200 in grants were distributed
Donations were received from
employees globally22

Who We Are

Patients

Learning Resources

Investing in our
employees’ learning,skills and careerdevelopment is
integral to ourcompany’s success.
We offer several
resources to support
our employees’
well‑being,learning and careerdevelopment whileproviding growth
opportunities.

PTC Therapeutics 2023 Corporate Sustainability Report

We have a variety ofresources aimed at
supporting employees indeveloping their technicaland behavioral skills aswell as encouraging theirpersonal development. In
2023, employees worldwide
engaged in nearly 8,800
hours of instructor-led
development training acrossall of PTC’s programs. In
addition to these sessions,employees get access to
self-paced resources that
promote self-discovery,
leadership development,
cultural awareness andcognitive diversity.

PeopleCommunity

Environment

Ethics & ComplianceAward-winning
Strengths‑Based Culture

Coaching and Mentoring
Opportunities

All our employees are invited
to take the CliftonStrengths
assessment, allowing themto identify their uniquestrengths. Understanding
our unique strengths helps tocreate fulfilling and thriving
lives for PTC employees,
both inside and outside of
the company. This leads toincreased engagement,
effective collaboration andcontinued development
while honoring andembracing diversity.

PTC established a Coachingand Mentoring Center of
Excellence, which provides
guidance and inspiration,
engages and empowers
employees, and acts asa catalyst for the positivechange and growth we wish
to achieve – individually, inteams and as an organization.

23

Who We Are

Patients

PeopleEmerging Leaders(EL) Program

Leadership
Excellence Program

GlobalOnboarding

The EL program is a
six-month, nominationbased, global programthat was createdspecifically for early
career stars at PTC
who demonstrate thepassion and traits tobecome successful
future leaders.
The program wasdeveloped with thegoal of establishinga healthy range ofdiversity at the top as
these emerging leadersadvance.

The Leadership
Excellence program
was designed to focus
on the continued
leadership developmentof employees at theexecutive level of theircareers at PTC. The
program concentrates
on honing the leadershipskills essential for
success including
accountable leadership,coaching and mentoring
capabilities, emotional
intelligence and effective
communication.

PTC recognizes
the importanceof establishingappropriate newhire expectations on
our culture, values
and behaviors when
new colleagues join
the company. The
cross-functional
Global Onboarding
Committee’s mission
is to ensure a quick andsuccessful onboarding
experience for
new hires.

PTC Therapeutics 2023 Corporate Sustainability Report

Community

Environment

Ethics & Compliance24

Who We Are

For us, changing the course of rarediseases isn’t a job, it is our purpose.
Our deep passion for patients drives us
to think differently about solutions andto work collaboratively as One PTC.

Patients

PeopleOur culture at PTC reflects this mission.
We endeavor to ensure that our employees
can bring their “whole authentic self” towork and strive to make a difference in thecommunities where we live and work.

Community

Environment

Ethics & Compliance

We especially value the importance of community and belonging intoday’s hybrid workforce and seek to foster and encourage open
discussions across geographies and departments. This open dynamic
allows us to learn from one another and pushes us toward making
lasting and impactful change for patients and our communities.

Demographics

48.1%

of employees
identify as male* (318)51.9%

of employees
identify as female* (343)

36%

40%

of PTC’s Board of Directors
identify as femaleof the Executive Committee
identify as female*Based on data for employees in the U.S., due to individual and geographical privacy and employment laws which prohibit collection of this information outside of the U.S.

PTC Therapeutics 2023 Corporate Sustainability Report25

Who We Are

Patients

PeopleGlobal Equality,
Diversity &Inclusion (ED&I)
Our ED&I program seeks to deliver on
several guiding pillars: cultural awareness,talent pipeline, community outreach andworking as OnePTC, all with the goal of
making a difference in the lives of ouremployees and the lives of our patients.
We believe in creating an environment
where all people feel they can bring theirwhole self to work and have a senseof belonging while performing at theirabsolute best.

Community“

Environment

Ethics & Compliance s we look to the future, the ED&I strategy at PTC will continue to stayA
flexible enough to adapt to the changing world, yet consistently remainaligned to PTC’s growth and expectations. My hope is that PTC will one
day have the most diverse workforce in the pharma industry, will be a
top inclusive organization and will be sought out by others to mirror the
successful achievement of equality.

Pamela Zapata
Senior Director, Global Equality, Diversity & Inclusion“

 e find many commonalities across geographies but also uniqueWdifferences. What works in one country may not in another and viceversa. It is important to cultivate it appropriately in and across all parts of
our operations. ED&I is everyone’s responsibility.

Jesse Sibarium
SVP and General Manager, CEMEA“

T he diversity of the Southern Cone, Andean Countries and Mexico (SAM)
region requires a special level of people and engagement to succeed people moved by passion and entrepreneurism that want to be better andto make the world better for the patients and their families. Those are thepeople we have at PTC in LATAM.

Joeli Mansim
VP and General Manager, SAM

PTC Therapeutics 2023 Corporate Sustainability Report26

Who We Are

Patients

PeopleCommunity

We have seven Employee Resource Groups (ERGs)
and three Business Resource Groups (BRGs).

ERGs

BRGs

ERGs raise awareness of social and community
issues, responding to community needs andcrises, celebrating important heritage months
and providing community outreach.

BRGs seek to foster a diverse,
supportive workplace environment
and include members who identify
with several of our ERGs.

API: Asian-Pacific Island ERG

ECP: Early Career Professionals

BEC: Black Empowerment Council

She Rises: Women of Colorin Pharma

MAGIC: Multicultural Alliance Groupof Inclusive Communities
OHLA: Organization for Hispanics/Latinx + Allies
PTC Pride: LGBTQ+ ERG
SAMMA: South America +Mexico Multicultural Alliance
W+IN: Women+ International Network

PTC Therapeutics 2023 Corporate Sustainability Report

Balance: Wellbeing

Environment

Ethics & Compliance

PTC Pride ERG orchestrated
an engaging andinformative Pride Monthcelebration in June. They
crafted and paraded avibrant float in the New
Jersey Pride Parade,a gesture that drewcolleagues from acrossthe region to Asbury Park ina show of solidarity.

The She Rises BRG brought
together company leaders
to underscore the criticalityof nurturing talent andexpanding professional
development avenues for
women of color. Througha series of insightful
meetings, She Rises
focused on dismantlingsystemic barriers andfostering an environment
where women of color are
empowered to ascend to
new heights in their careers.

27

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Community

PTC Therapeutics 2023 Corporate Sustainability Report28

Who We Are

We are committed to not only caring forour patients but also striving to meet theneeds of people in our communities.
We empower employees to make adifference both internally and externally– this includes giving back to our local
and global communities.
In 2023, PTC provided funding tosupport a wide array of causes. Our
Global Outreach Committee helps
orchestrate company-wide volunteer
and giving opportunities that are
guided by five fundamental pillars:
students, community needs, patients,
planet and emergency relief.

Patients

PeopleCommunityStudents

Community
Needs

Patients

Learners
Today
Leaders
Tomorrow

Supporting
Our
Communities
Globally

Our
Passionand
PurposeEnvironment

Ethics & Compliance

PlanetEmergency
Relief

One PTC
Sustaining
the World

GlobalCrisisResponseand Support

PTC GLOBAL OUTREACH

PTC Therapeutics 2023 Corporate Sustainability Report29

Who We Are

Empowering Future
STEM Leaders
PTC is dedicated to encouraging and supporting
STEM (Science, Technology, Engineeringand Math) education. Throughout 2023, PTC
team members connected directly with STEM
students around the world to share perspectives,
encouragement and hands-on experience.

“Our aim was to inspire students to consider STEM
subjects in their secondary level education, as
well as a career in STEM. We showed the multiple
pathways that a career in STEM can lead to, how we
use social media as a means of communication andthat you don’t need to be a scientist to work at PTC.
Claire DoyleManager, International Tax

PTC Therapeutics 2023 Corporate Sustainability Report

Patients

PeopleThe students from
Passaic Academyof Science andEngineering (PASE)
along with theirteachers, visited
our labs in
Bridgewater, N.J.

In honor of International
Day of Women and Girlsin Science, colleagues
from the Dublin, Ireland
office moderated apanel discussion withsixth class students
from Scoil Mhuire Girls
National School Lucan.

Community

Environment

In recognition of
Women and Girls in
STEM Day, PTC held awebinar for students
attending PASE.
Members of the W+IN
ERG shared their career
journeys with students,
gave advice andanswered questions.

The OHLA ERG visited
Montclair State University
in N.J. on National STEM
Day to host a panel
discussion focused on
discovering pathways toenter a STEM career.

Ethics & Compliance

PTC participated in a STEAM fair atValley Elementary school in the Poway
Unified School District, CA, hosting ahand washing science experiment.

Members from PTC’s team in the Bostonarea volunteered with the organization
Science from Scientists for an escaperoom-style forensic science lessonorganized for middle and high school
students visiting the U.S. from Japan.

30

Who We Are

Patients

PeopleCommunity

Environment

Community Needs
and Volunteerism

Team members from ClinicalPharmacology and DMPK in
N.J. organized a food driveand volunteered with theCommunity Food Bank of N.J.,
packing about 5,000 bagsof pasta. Colleagues fromthe N.J. offices collectively
donated 175 pounds of food.

PTC employees regularly give back to local communities, helping
to make a difference in the communities where they live and work.

School Supplies

Tech Donations

Team members across
N.J. sponsored the Jersey
Cares School Supply Driveand filled 150 backpacks
with school supplies forchildren in need. The
PTC team in California
collected and donatedbackpacks and schoolsupplies to the San Jose
Family Shelter at the startof the school year.

PTC in Germany donated 18 iPhones to PCs für Alle (PCs forAll), a non-profit organization in Germany. The devices are
refurbished and then handed over free of charge to schools,
charitable NGOs and financially disadvantaged people.
The PTC IT Team donated 100 used laptops to three localorganizations focused on science and education, and 180
laptops were donated to employees.
PTC in Brazil donated 23 computers to the Instituto Vocação
(“Vocation Institute”), part of the institute’s collection tobenefit the community of Campo Limpo in São Paulo.

PTC Therapeutics 2023 Corporate Sustainability Report

Ethics & Compliance

Warm Clothing
Campaign

Supporting
Volunteers

Film Screening
Fundraiser

PTC in Brazil ran a Warm
Clothing Campaign inpartnership with theSão Paulo Red Cross.
They donated warm
clothing, blankets,
personal hygiene andcleaning products,
and raised funds forcommunities in need.

The MAGIC ERG donatedto the Fundación Pablo
Horstmann, a non-profit
organization committed
to improving healthcare and education forchildren, the sick, theelderly and the disabled.
The donation supported
three volunteering
healthcare professionals
from Spain to travel
to hospitals in Lamu
and Kenya.

The BEC ERG hosted ascreening of “The Color
Purple” in December as afundraiser and donatedproceeds of the screening
to the Pregnancy Aid &Information Center in
Raritan, N.J.

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Ethics & Compliance

Environment
PTC Therapeutics 2023 Corporate Sustainability Report32

Who We Are

Patients

PeopleCommunity

Environment

Ethics & ComplianceGreen Operations: 2023 Key Efforts

Caring for ourcommunities also
includes caring about
the environment. Asa science‑based
company, we
appreciate theimpact we have on
the environment. We
strive to be good
citizens of the world
and make changes
towards becoming abetter planet.

PTC Therapeutics 2023 Corporate Sustainability Report he Bridgewater, N.J. facility’s participation in our recycling
Z T
program yielded 76.6 tons recycled at a 58% recycling rate.
 7,500 pounds (59%) of the hazardous waste generated
Z 3
in research and manufacturing operations was recycled
through fuel blending processes for energy recovery.
 ur laboratories met all environmental standards
Z O
and have consistently passed inspections
by multiple government authorities.
 e continue to replace lightbulbs at our
Z W
corporate headquarters with LED lighting.
 e provide charging stations for electric
Z W
vehicles at all of our N.J. facilities.
 ore than 20% of electricity used at our corporate
Z M
headquarters was generated through wind power.

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PTC has adopted sustainability practices in its offices by introducing recycling,
composting and food waste reduction, implemented energy saving practices andeliminated the use of plastics such as drink bottles and plastic tableware.
The Green Team at PTC

Urban Gardening

Tree Planting for New Hires

The “Green Team” inour Zug office works
to create a moreenvironmentally
sustainable workplaceand inspire positivechange in the community.
They have madeconsiderable impacts
which has inspired others
in offices around theworld to embrace
similar practices.

The Green Team hosted an
Urban Gardening Workshop
to teach how to plant fruits,
vegetables and herbs intheir gardens, terraces andbalconies. The goal was toinspire and encourage everyone
to grow their own food and,with that, integrate sustainable
practices into their lives.

We planted 15 new trees
for each new hire thatjoined PTC in the country inwhich they had been hired.
This demonstrates ourcommitment to sustainability
and a reminder of thepositive difference we can all
make in our communities.
In 2023, PTC planted:

PTC in Dublin planted a fruitand vegetable garden on theirbalcony and starter packs were
given out for employees toplant at home.

• 1,470 trees in the U.S.

PTC Therapeutics 2023 Corporate Sustainability Report• 260 trees in LATAM• 380 trees in EMEA/APAC

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Ethics & ComplianceDisposal Collections

In PTC offices around the world, we organize collections ofbatteries, can seals and bottle caps throughout the year, which are
directed to institutions that dispose of these items properly.
Tree Planting and Cleanup Activities

For the second year in a row, PTC in Zug partnered with
Almighty Tree and planted 100 trees at a location that had beenheavily impacted by bark beetle infestations, which has a direct
link to climate change.
The Hopewell Community Environmental Team organized a tree
planting event at The Watershed Institute in N.J. Team members
also volunteered at one of the nine different 2023 Earth Day
Stream Cleanup events on Earth Day across central N.J.
A canal cleanup was organized by PTC in Dublin in recognitionof World Earth Day 2023.

PTC Therapeutics 2023 Corporate Sustainability Report35

Who We Are

Patients

PeopleCommunity

Environment

Ethics & Compliance

Encouraging
Reusable andGreen Materials
PTC implemented the K-cycle® recycling program in the N.J.
offices. This program allows us to fully recycle the Keurig
K-Cup® pods, giving all materials a second life and reducing
waste disposal in the process. In 2023, we recycled 1750
pounds of K-Cup® material. Seventy-five percent of the pod isconverted to compost and 25 percent of the pod is converted
to recycled product.

The research laboratories in N.J. adopted sometargeted plastic recycling and reuse programswith Terracycle, Corning and Integra, mainly
focused on Styrofoam containers and exterior
packaging of laboratory supplies. In 2023, werecycled 900 pounds with these three companies.

PTC Therapeutics 2023 Corporate Sustainability Report

PTC in Dublin uses green officesupplies, supplying reusable notepads and coffee cups to reduce
consumption of one-use items in theoffice and at home. Non-chemicalcleaning supplies are also used on site,and chemical-free feminine hygiene
products are made available.

PTC in Brazil distributed
sustainable thermal cups to
employees to discourage theuse of single-use plastics.

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Ethics & Compliance
PTC Therapeutics 2023 Corporate Sustainability Report37

Who We Are

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PeopleCommunity

Global Compliance Program

Code of Business Conduct & Ethics

Our Global Compliance Program is alignedwith the “Compliance Program Guidancefor Pharmaceutical Manufacturers,”
developed by the United States
Department of Health and Human Services,
Office of Inspector General and other laws
and regulations that govern our industry.

PTC held training sessions for its employees on its
refreshed Code of Business Conduct and Ethics
to help the company best fulfill its commitment topatients while acting with integrity. The Code contains
principles and standards that guide PTC’s businessbehavior throughout the world.

The program is designed to ensurecompliance with company policies andthe laws and regulations applicable to thepharmaceutical industry.

Confidential Hotline

PTC provides multiple channels forcommunication and raising potential
compliance concerns. Regular compliancetraining for all applicable employees
is required as part of the program.
Compliance policies, training, andeducation are tailored to the audience andtranslated into local language as necessary.

PTC Therapeutics 2023 Corporate Sustainability Report

Environment

Ethics & Compliance

CODE OFBUSINESSCONDUCTAND ETHICSREVISED NOVEMBER 2022

There are many resources available for raisingquestions or concerns about the topics discussed in
the Code, compliance issues or a suspected violation.
Employees are encouraged to speak to their manager
first. They may also raise a concern with Compliance,
Legal or Human Resources or report via PTC’s
confidential hotline.
Our confidential hotline can be accessed 24 hours
a day, seven days a week and is offered in multiple
languages. Concerns may be reported by phone oronline. This hotline is hosted by a third party and allreports to it are followed up in a timely manner.

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PTC Therapeutics 2023 Corporate Sustainability Report

Patients

PeopleCommunity

Environment

Ethics & Compliance

Cybersecurity Risk Management and Strategy

Cybersecurity Governance and Oversight

We have a multilayered approach
for assessing, identifying
and managing cybersecurity
risks that is designed tohelp protect informationfrom internal and externalcyber threats by mitigatingrisk while ensuring businessresiliency. Our cybersecurity
prevention methods include
implementing the National
Institute of Standards andTechnology cybersecurity
framework, instituting a training
and compliance program on
cybersecurity for all employees,
completing a yearly external
audit and penetration test,
conducting vulnerability scans
and remediations and monitoring
threat intelligence feeds.

Our Board of Directors
administers its
cybersecurity risk
oversight function
primarily through the
Audit Committee of theBoard of Directors. In
accordance with our Audit
Committee Charter, ourChief Information Officer(CIO), provides periodic
updates to our Audit
Committee regarding
PTC’s cybersecurity andother technology risks,internal controls andprocedures, including
the PTC’s plan to mitigate
cybersecurity risk andrespond to data breaches.

We have also establisheda global incident responsemanagement standard
operating procedure(GIRM). Our GIRM
provides step-by-step
instructions for managing
any global incident which
is disruptive to the delivery
and operation of our IT
services and systems.
We engage third parties,
including independent
privacy assessors,
computer security firms
and risk management andgovernance experts toenhance our cybersecurity
oversight.

Our CIO oversees acybersecurity teamthat has more than 15
years’ experience incybersecurity along with
degrees in cybersecurity,and industry recognized
security certifications
such as Certified
Information Systems
Security Professionaland Certified Information
Security Manager.

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Who We Are

Patients

PeopleBoard of Directors

Community

Environment

Ethics & ComplianceMary L. Smith
THE VENG GROUP

PTC’s Board of Directors work with our management team to ensure that our culture
is conducive to a productive and healthy work setting and that the Company
approaches corporate governance, environmental and social issues in a way thatis consistent with our culture.

David P. Southwell
FORMER CEO, TSCAN THERAPEUTICS

Michael Schmertzler

Allan Jacobson, Ph.D.

Glenn D. Steele, Jr., M.D., Ph.D.

CHAIRMAN

UNIVERSITY OF MASSACHUSETTS
CHAN MEDICAL SCHOOLCHAIRMAN, GSTEELE HEALTH SOLUTIONSMatthew B. Klein,
M.D., M.S., FACS

Stephanie S. Okey, M.S.

Alethia YoungFORMER SVP, HEAD OF NORTHAMERICA, RARE DISEASE - GENZYMECHIEF FINANCIAL OFFICER, BICYCLE THERAPEUTICS

William F. Bell, Jr.

Emma Reeve

Jerome B. Zeldis, M.D., Ph.D

MANAGING DIRECTOR AND HEAD OF HEALTHCARESERVICES PRACTICE, L.E.K. CONSULTING

INDEPENDENT BOARD DIRECTOR

INDEPENDENT BOARD DIRECTORCHIEF EXECUTIVE OFFICER , PTC

PTC Therapeutics 2023 Corporate Sustainability Report40