[IBI Data Standards and Sharing Working Group]

Data Standardization& Utilization in South Korea

Nov 14. 2022

Korea Brain Research InstituteJa Wook Koo, Ph.D.

2Korea Brain Research Institute (KBRI)- First Gov’t endowed Institute for Brain Research in Korea, 2011

“Enactment of the Brain Research Promotion Act ”(Article 17, Establishment of Research Institute, by Korean National Assembly, July 1998)

Aims: To conduct, utilize, and support brain research andmaintain and develop a close cooperative system among
academia, research institutes, and industries.
KISTIBSKBRI

3KBRI Research buildings
Implementation Research(Step 3, Cooperation Bldg.)〮 Cost : 18.9 billion won〮 Area : 6,460㎡〮 Period : ‘19 ~ ’23 (Completion, next year)

Step 3. Cooperation bldg.

Basic ResearchApplied Research(Step 1, Left-hemisphere Bldg. )(Step 2, Right-hemisphere Bldg.)〮 Cost : 88.9 billion won〮 Area : 20,583㎡〮 Period : ‘11 ~ ‘14 (Completed)〮 Cost : 28.75 billion won〮 Area : 11,065㎡〮 Period : ‘19 ~ ’22 (completed, this year)

Step 2. Right hemisphere bldg.

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Implementation research in KBRI
KBRI
Research Groups

Domestic/InternationalResearch groups

5Database Development for National Brain Research Resources
Brain Center for Innovation of Technology & Informatics (Brain-Citi)
ResearchResearch

Neuroimage

Brain Data
Integrated Management
SystemBrain Data
Convergence Research
Platform

Verification

Predictiveanalysis• Circuit-based molecularmechanism• Symptom-based circuit principle+Molecules

Medicine
Brain bank
Link system

Registration

Visualization

Integrative
analysis

Convergence
research

Neurosignals

Information
management

Education
Brain images

Information
linkage

Experimental Resource
Management System
Experimentmanagement

Convergence Infrastructure for Brain Research

Equipment
management

Resultmanagement

Medicine• Personalized therapeutics• Big data-based 4D diagnostic
marker+Solution for DATA Deposit-Analysis-Application

Industry
Operation

Industry

Behavioral
reports

Analysis

TechnologySecurity• Emotion-responsive Neuro-chip• Customized AI for personalized
IoT careAdvanced Neuro-informatics System for Global Brain Research Collaboration

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Data standardization in Brain Science7

Data standardization in Brain Science
Main Category

Classification-ii

MolecularOMICS

Information

Classification-iii

FormatLink

Genomics
Proteomics
Transcriptomics
Epigenomics
Metabolomics
Other

Molecular Structure

NeuroImaging

Macro(In-vivo)

Single Cell Portal

https://singlecell.broadinstitute.org/single_cell

Neuroscience Multi-omic Archive(NeMO)

https://nemoarchive.org/

Crystallography Open Database (COD)

http://www.crystallography.net/cod/

Peptides and proteins

Worldwide Protein Data Bank (wwPDB)

https://www.wwpdb.org/

Larger assemblies

Electron Microscopy Data Bank (EMDB)

http://www.emdataresource.org/index.html

MRI/fMRIBIDS / DICOM

Small molecules

https://bids.neuroimaging.io/
https://www.dicomstandard.org/

PET/SPECTCT/UltrasoundMicro(ex-vivo)
https://www.nature.com/articles/d41586-020-00594-4
Modeling

EEG, MEG, iEEG(ECoG)

BIDS

https://bids.neuroimaging.io/index.html

Optical Imaging(Cell, Tissue)

IDR(Image Data Resource)

http://idr.openmicroscopy.org/tissue/

Electron Microscopy(Molecules to cells)
Other

EMPIAR(Electron Microscopy Public Image Archive)
BioImage Archive

Brain mapping(Macro)

NITRC(Reconstruction data)
Etc

Biosignals
Behaviors

NIDM-Results
Brain mapping(Micro)

DVID

Ca2+ imaging

LFP, Endomicroscopy, Multi-photon

Electrophysiology

Single Unit, LFP, voltammetry, Ion channel

Pre-clinical
Clinicalhttps://www.ebi.ac.uk/pdbe/emdb/empiar/about
https://www.ebi.ac.uk/bioimage-archive/
https://www.nitrc.org/projects/brainmap/
https://www.nature.com/articles/sdata2016102
https://github.com/janelia-flyem/dvid

Thanks~!

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Korea Brain Research Institute“Global Leading Institute in Brain Research”“ The First on the Best”“Contribute to health and happiness of human through brain research”

10International collaborative Brain Research– by Global Emotion & Addiction Project
Step1 ‘Aggregation’ [‘22-’23]

Step2 ‘Sophistication’ [‘24-’25]

Step3 ‘Application’ [‘26-’27]

Multi-scale Emotion-Brain Mapping

Refining Brain Maps by integrative analysis

Big-data based Mental Health Strategy

Micro/MesoBrain Map

Macro-MolecularBrain Map

Psychiatric Brain Mapping

Structure-Function
Big data

Neuromodulatory
Resource Technology

Psychiatric marker identification& Neuromodulation

Multi-scale Circuit/Molecule Brain Mapping for Mental Health Strategy

11International collaborative Brain Research– by Global Emotion & Addiction Project
Norway(EU)CanadaUSA

China

Portugal(EU)JapanKorea

Multi-scale Brain Mapping for Emotional functions- Emotional system & Psychiatric disordersl Reward/Motivation - Addictionl Stress - Depressionl Fear - PTSD, Anxietyl Sociality - ASDl Schizophrenia, Bipolar, OCD
è How emotional behaviors are modulated in health and disease

Seoul

Suwon/Daejeon

Daegu

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IBI Daegu Conference 2022 – by Global emotion & addiction project[ Topic ]1. Reward - Addiction
2. Stress - Depression
3. Fear - PTSD, Anxiety
4. Schizophrenia
5. Neuro-engineering

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IBI Daegu Conference 2022 – by Global emotion & addiction project at KBRI
Linda J. Richards, PhD• Edison Professor and Chair,
Department of Neuroscience,
Washington University• Director, McDonnell Center for
Cellular & Molecular Neurobiology,
Washington University

Alan P. Jasanoff, PhD••

Professor, Departments of BiologicalEngineering, Brain and CognitiveSciences, Nuclear Science andEngineering, MIT McGovern InstituteDirector, Center for NeurobiologicalEngineering, MIT McGovern InstituteMatt Girgenti, PhD

Yong Kim, PhD

Amar Sahay, PhD• Assistant Professor,
Division of MolecularPsychiatry,
Yale University• Deputy Director for
Research, VA National
PTSD Brain Bank

• Associate Professor,
Department of
Neurosurgery,
Rutgers University• Core Member, Brain
Health Institute,
Rutgers University• Associate Professor,
Department of Psychiatry,Center for Regenerative
Medicine at MGH• Associate Member of theBroad Institute of MIT andHarvard

Peng Cao, PhD

Sung Han, PhD

Tiago Branco, MD, PhD• Principal Investigator,
National Institute of
Biological Sciences atBeijing• Assistant Professor,
Clayton Foundation
Laboratories for
Peptide Biology,Salk Institute• Professor, Sainsbury
Wellcome Centre for Neural
Circuits and Behaviour,
University College London