LARGE Publications
2016
Nakao H, Harada T, Nakao K, Kiyonari H, Inoue K, Furuta Y, Aiba A. (2016) A
possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mousezygotes. Genesis. 54(2):65-77.
Shi D, Usami F, Komatsu K, Oka S, Abe T, Uemura T, Fujimori T. (2016) Dynamics ofplanar cell polarity protein Vangl2 in the mouse oviduct epithelium. Mech Dev.
141:78-89.
Ibeh BO, Furuta Y, Habu JB, Ogbadu L. (2016) Humanized mouse as an appropriate
model for accelerated global HIV research and vaccine development: current trend.
Immunopharmacol Immunotoxicol. 1-13.
Toya, M., Kobayashi, S., Kawasaki, M., Shioi, G., Kaneko, M., Ishiuchi, T., Misaki, K.,
Meng,.W, and Takeichi, M. (2016) CAMSAP3 orients the apical-to-basal polarity of
microtubule arrays in epithelial cells. Proc Natl Acad Sci U S A. 113(2):332-7.
Mukai, H., Muramatsu, A., Mashud, R., Kubouchi, K., Tsujimoto, S., Hongu, T.,
Kanaho, Y., Tsubaki, M., Nishida, S., Shioi, G., Danno, S., Mehruba, M., Satoh, R. andSugiura, R. (2016) PKN3 is the major regulator of angiogenesis and tumor metastasis inmice. Sci Rep. 6:18979. doi: 10.1038/srep18979.
Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) Intra-spindle Microtubule
Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse
Development. Cell Rep. 15(1):54-60.
Isozaki T, Komenoi S, Lu Q, Usuki T, Tomokata S, Matsutomo D, Sakai H, Bando K,
Kiyonari H, Sakane F. (2016) Deficiency of diacylglycerol kinase η induces
lithium-sensitive mania-like behavior. J Neurochem.138(3), 448-456.

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T,
Blencowe BJ, Nakagawa S. (2016) Gomafu lncRNA knockout mice exhibit mild
hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Sci Rep. 6:27204. doi: 10.1038/srep27204.
Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe
T, Kano K, Aoki J, Hayasaka H, Miyasaka M. (2016) Lysophosphatidic acid receptors
LPA4 and LPA6 differentially promote lymphocyte transmigration across highendothelial venules in lymph nodes. Int Immunol. 28(6):283-92.
Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, Abe T, Kitazawa
S. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during
postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198. doi:
10.1038/srep25198.
Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K,
Furuta Y, Katayama I, Tsukita S. (2016) Dose-dependent role of claudin-1 in vivo inorchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 113(28):E4061-8.
doi: 10.1073/pnas.1525474113.
Hata K, Yanase N, Sudo K, Kiyonari H, Mukumoto Y, Mizuguchi J, Yokosuka T.
(2016) Differential regulation of T-cell dependent and T-cell independent antibody
responses through arginine methyltransferase PRMT1 in vivo. FEBS Lett.
590(8):1200-10. doi: 10.1002/1873-3468.12161.
Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H,
Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M,
Hastings MH, Kiyonari H, Okamura H. (2016) Gpr176 is a Gz-linked orphan
G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun.
7:10583. doi: 10.1038/ncomms10583.
Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen PM, Morita Y,
Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K,

Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T, Nishi E. (2016) Nardilysin Is
Required for Maintaining Pancreatic β-Cell Function. Diabetes. 65(10):3015-27.
Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N,
Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y,
Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM. (2016)
Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of theAutism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 91(5):1052-68.
Usuki T, Takato T, Lu Q, Sakai H, Bando K, Kiyonari H, Sakane, F. (2016) Behavioral
and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout
mice. Brain Res. 1648 (Part A), 193–201.
Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G,
Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y.
(2016) CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development.
Genes Cells. 21(9):994-1005.
Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y,
Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y. (2016) CAPS1 RNA
Editing Promotes Dense Core Vesicle Exocytosis. Cell Reports 17(8): 2004-2014.
Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S,
Naito M, Kiyonari H, Fujii M. (2016) USP10 Is an Essential Deubiquitinase for
Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Stem
Cell Reports. 7(6):1116-1129.
Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y,
Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T.
(2016) Targeted disruption of the mouse protein phosphatase ppm1l gene leads tostructural abnormalities in the brain. FEBS Lett. 590(20):3606-3615.

2015
Hoshino, H., Shioi, G. and Aizawa, S. (2015) AVE protein expression and visceralendoderm cell behavior during anterior-posterior axis formation in mouse embryos:
Asymmetry in OTX2 and DKK1 expression. Dev Biol 402(2): 175-91.
Hiramuki, Y., Sato, T., Furuta, Y., Surani, M. A. and Sehara-Fujisawa, A. (2015) Mest
but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration. PLoS One 10(6):e0130436.
Oshiro, H., Hirabayashi, Y., Furuta, Y., Okabe, S. and Gotoh, Y. (2015) Up-regulationof HP1gamma expression during neuronal maturation promotes axonal and dendritic
development in mouse embryonic neocortex. Genes Cells 20(2): 108-20.
Sato, S., Yajima, H., Furuta, Y., Ikeda, K. and Kawakami, K. (2015) Activation of Six1
Expression in Vertebrate Sensory Neurons. PLoS One 10(8): e0136666.
Fukuda, N., Naito, S., Masukawa, D., Kaneda, M., Miyamoto, H., Abe, T., Yamashita,Y., Endo, I., Nakamura, F. and Goshima, Y. (2015) Expression of ocular albinism 1(OA1), 3, 4- dihydroxy- L-phenylalanine (DOPA) receptor, in both neuronal andnon-neuronal organs. Brain Res 1602: 62-74.
Recuenco, M. C., Ohmori, T., Tanigawa, S., Taguchi, A., Fujimura, S., Conti, M. A.,
Wei, Q., Kiyonari, H., Abe, T., Adelstein, R. S. and Nishinakamura, R. (2015)
Nonmuscle

MyosinII

Regulates

theMorphogenesisofMetanephricMesenchyme-Derived Immature Nephrons. J Am Soc Nephrol 26(5): 1081-91.
Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M.,
Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. andNakashima, K. (2015) miR-199a Links MeCP2 with mTOR Signaling and Its
Dysregulation Leads to Rett Syndrome Phenotypes. Cell Rep 12(11): 1887-901.
Arimoto, K., Hishiki, T., Kiyonari, H., Abe, T., Cheng, C., Yan, M., Fan, J. B.,

Futakuchi, M., Tsuda, H., Murakami, Y., Suzuki, H., Zhang, D.E. and Shimotohno, K.
(2015) Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an
ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res 35(5):351-8.
Tanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A. and Tsukita, S. (2015)
Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates
colonic inflammation in mice. Gut 64(10): 1529-38.
Nojiri, T., Hosoda, H., Tokudome, T., Miura, K., Ishikane, S., Otani, K., Kishimoto, I.,
Shintani, Y., Inoue, M., Kimura, T. Sawabata, N., Minami, M., Nakagiri, T., Funaki, S.,
Takeuchi, Y., Maeda, H., Kidoya, H., Kiyonari, H., Shioi, G., Arai, Y., Hasegawa, T.,
Takakura, N., Hori, M., Ohno, Y., Miyazato, M., Mochizuki, N., Okumura, M. andKangawa, K. (2015) Atrial natriuretic peptide prevents cancer metastasis throughvascular endothelial cells. Proc Natl Acad Sci U S A 112(13): 4086-91.
Lee, M. S., Hwang, K. S., Oh, H. W., Ji-Ae, K., Kim, H. T., Cho, H. S., Lee, J. J.,
Yeong Ko, J., Choi, J. H., Jeong, Y. M., You, K.H., Kim, J., Park, D.S., Nam, K.H.,
Aizawa, S., Kiyonari, H., Shioi, G., Park, J.H., Zhou, W., Kim, N.S. and Kim, C.H.
(2015) IFT46 plays an essential role in cilia development. Dev Biol 400(2): 248-57.
Imai, Y., Kobayashi, Y., Inoshita, T., Meng, H., Arano, T., Uemura, K., Asano, T.,
Yoshimi, K., Zhang, C. L., Matsumoto, G., Ohtsuka, T., Kageyama, R., Kiyonari, H.,
Shioi, G., Nukina, N., Hattori, N. and Takahashi, R. (2015) The Parkinson's
Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through theEndosomal Pathway. PLoS Genet 11(9): e1005503.
Imai, N., Suzuki, M., Hayashi, K., Ishigami, M., Hirooka, Y., Abe, T., Shioi, G., Goto,
H. and Fujimoto, T. (2015) Hepatocyte-Specific Depletion of UBXD8 Induces
Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One 10(5): e0127114.
Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima,T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, SI., Katagiri, H., Honda, H.,Kiyonari, H., Uchida, T. and Asano, T. (2015) Prolyl Isomerase Pin1 Negatively
Regulates AMPK by Associating with the CBS Domain in the gamma-subunit. J Biol
Chem. 290(40):24255-66.
Kurimoto, K., Yabuta, Y., Hayashi, K., Ohta, H., Kiyonari, H., Mitani, T., Moritoki, Y.,
Kohri, K., Kimura, H., Yamamoto, T., Katou, Y., Shirahige, K. and Saitou, M. (2015)
Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from
Mouse Embryonic Stem Cells. Cell Stem Cell 16(5): 517-32.
Hayashi, K., Momoi, Y., Tanuma, N., Kishimoto, A., Ogoh, H., Kato, H., Suzuki, M.,
Sakamoto, Y., Inoue, Y., Nomura, M., Kiyonari, H., Sakayori, M., Fukamachi, K.,
Kakugawa, Y., Yamashita, Y., Ito, S., Sato, I., Suzuki, A., Nishio, M., Suganuma, M.,
Watanabe, T. and Shima, H. (2015) Abrogation of protein phosphatase 6 promotes skincarcinogenesis induced by DMBA. Oncogene 34(35): 4647-55.
Iezaki, T., Onishi, Y., Ozaki, K., Fukasawa, K., Takahata, Y., Nakamura, Y., Fujikawa,K., Takarada, T., Yoneda, Y., Yamashita, Y., Shioi, G. and Hinoi, E. (2015) The
Transcriptional

Modulator

Interferon-Related

Developmental

Regulator

1inOsteoblasts Suppresses Bone Formation and Promotes Bone Resorption. J Bone Miner
Res. 2015 Sep 22. doi: 10.1002/jbmr.2720.
Dong, B., Endo, I., Ohnishi, Y., Kondo, T., Hasegawa, T., Amizuka, N., Kiyonari, H.,
Shioi, G., Abe, M., Fukumoto, S. and Matsumoto, T. (2015) Calcilytic Ameliorates
Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking
Autosomal Dominant Hypocalcemia (ADH). J Bone Miner Res. 2015 May 12. doi:
10.1002/jbmr.2551.
Hashidate-Yoshida, T., Harayama, T., Hishikawa, D., Morimoto, R., Hamano, F.,
Tokuoka, S. M., Eto, M., Tamura-Nakano, M., Yanobu-Takanashi, R., Mukumoto, Y.,
Kiyonari, H., Okamura,T., Kita, Y., Shindou, H. and Shimizu, T. (2015) Fatty acidremodeling by LPCAT3 enriches arachidonate in phospholipid membranes andregulates triglyceride transport. Elife 4. doi: 10.7554/eLife.06328.

Mukai, S., Yabuta, N., Yoshida, K., Okamoto, A., Miura, D., Furuta, Y., Abe, T. andNojima H. (2015) Lats1 suppresses centrosome overduplication by modulating thestability of Cdc25B. Sci Rep 5:16173. doi: 10.1038/srep16173.
Irie, M., Yoshikawa, M., Ono, R., Iwafune, H., Furuse, T., Yamada, I., Wakana, S.,
Yamashita, Y., Abe, T., Ishino, F., Kaneko-Ishino, T. (2015) Cognitive Function
Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in
Eutherians, PLoS Genet 11(9):e1005521.
Arimoto K, Hishiki T, Kiyonari H, Abe T, Cheng C, Yan M, Fan JB, Futakuchi M,
Tsuda H, Murakami Y, Suzuki H, Zhang DE, Shimotohno K. (2015) Murine Herc6
Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent
Function in Seminal Vesicles. J Interferon Cytokine Res. 35(5):351-8.

2014
Oki, T., Nishimura, K., Kitaura, J., Togami, K., Maehara, A., Izawa, K.,
Sakaue-Sawano, A., Niida, A., Miyano, S., Aburatani, H., Kiyonari, H., Miyawaki, A.
and Kitamura, T. (2014) A novel cell-cycle-indicator, mVenus-p27K-, identifies
quiescent cells and visualizes G0-G1 transition. Sci Rep 4: 4012.
Kawaue, T., Sagou, K., Kiyonari, H., Ota, K., Okamoto, M., Shinoda, T., Kawaguchi, A.
and Miyata, T. (2014) Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice:visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage
in the developing mammalian brain. Dev Growth Differ 56(4): 293-304.
Watanabe, S., De Zan, T., Ishizaki, T., Yasuda, S., Kamijo, H., Yamada, D., Aoki, T.,
Kiyonari, H., Kaneko, H., Shimizu, R., Yamamoto, M., Goshima, G. and Narumiya, S.
(2013) Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during
mouse fetal erythropoiesis. Cell Rep 5(4): 926-32.
Goriki, A., Hatanaka, F., Myung, J., Kim, J. K., Yoritaka, T., Tanoue, S., Abe, T.,
Kiyonari, H., Fujimoto, K., Kato, Y., Todo, T., Matsubara, A., Forger, D. and Takumi,
T. (2014) A novel protein, CHRONO, functions as a core component of the mammalian
circadian clock. PLoS Biol 12(4): e1001839.
Hayashi, S., Inoue, Y., Kiyonari, H., Abe, T., Misaki, K., Moriguchi, H., Tanaka, Y.
and Takeichi, M. (2014) Protocadherin-17 mediates collective axon extension by
recruiting actin regulator complexes to interaxonal contacts. Dev Cell 30(6): 673-87.
Inoue, T., Hoshina, N., Nakazawa, T., Kiyama, Y., Kobayashi, S., Abe, T., Yamamoto,T., Manabe, T. and Yamamoto, T. (2014) LMTK3 deficiency causes pronounced
locomotor hyperactivity and impairs endocytic trafficking. J Neurosci 34(17): 5927-37.
Kitamura, A., Sasaki, Y., Abe, T., Kano, H. and Yasutomo, K. (2014) An inherited
mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med 211(12):2385-96.

Miyazaki, H., Oyama, F., Inoue, R., Aosaki, T., Abe, T., Kiyonari, H., Kino, Y.,
Kurosawa, M., Shimizu, J., Ogiwara, I., Yamakawa, K., Koshimizu, Y., Fujiyama, F.,
Kaneko, T., Shimizu, H., Nagatomo, K., Yamada, K., Shimogori, T., Hattori, N., Miura,
M. and Nukina, N. (2014) Singular localization of sodium channel beta4 subunit inunmyelinated fibres and its role in the striatum. Nat Commun 5: 5525.
Nakahata, S., Ichikawa, T., Maneesaay, P., Saito, Y., Nagai, K., Tamura, T., Manachai,N., Yamakawa, N., Hamasaki, M., Kitabayashi, I. Arai, Y., Kanai, Y., Taki, T., Abe, T.,
Kiyonari, H., Shimoda, K., Ohshima, K., Horii, A., Shima, H., Taniwaki, M.,
Yamaguchi, R. and Morishita, K. (2014) Loss of NDRG2 expression activatesPI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat
Commun 5: 3393.
Ohkubo, N., Matsubara, E., Yamanouchi, J., Akazawa, R., Aoto, M., Suzuki, Y., Sakai,
I., Abe, T., Kiyonari, H., Matsuda, S., Yasukawa, M. and Mitsuda, N. (2014) Abnormal
behaviors and developmental disorder of hippocampus in zinc finger protein 521(ZFP521) mutant mice. PLoS One 9(3): e92848.
Okumura, S., Fujita, T., Cai, W., Jin, M., Namekata, I., Mototani, Y., Jin, H., Ohnuki,Y., Tsuneoka, Y., Kurotani, R. Suita, K., Kawakami, Y., Hamaguchi, S., Abe, T.,
Kiyonari, H., Tsunematsu, T., Bai, Y., Suzuki, S., Hidaka, Y., Umemura, M., Ichikawa,Y., Yokoyama, U., Sato, M., Ishikawa, F., Izumi-Nakaseko, H., Adachi-Akahane, S.,
Tanaka, H. and Ishikawa, Y. (2014) Epac1-dependent phospholamban phosphorylation
mediates the cardiac response to stresses. J Clin Invest 124(6): 2785-801.
Susaki, E. A., Tainaka, K., Perrin, D., Kishino, F., Tawara, T., Watanabe, T. M.,
Yokoyama, C., Onoe, H., Eguchi, M., Yamaguchi, S., Abe, T., Kiyonari, H., Shimizu,Y., Miyawaki, A., Yokota, H. and Ueda, HR. (2014) Whole-brain imaging withsingle-cell resolution using chemical cocktails and computational analysis. Cell 157(3):726-39.
Tamai, S., Imaizumi, K., Kurabayashi, N., Nguyen, M. D., Abe, T., Inoue, M., Fukada,Y. and Sanada, K. (2014) Neuroprotective role of the basic leucine zipper transcription
factor NFIL3 in models of amyotrophic lateral sclerosis. J Biol Chem 289(3): 1629-38.
Yano, K., Carter, C., Yoshida, N., Abe, T., Yamada, A., Nitta, T., Ishimaru, N., Takada,K., Butcher, G. W. and Takahama, Y. (2014) Gimap3 and Gimap5 cooperate tomaintain T-cell numbers in the mouse. Eur J Immunol 44(2): 561-72.
Morimoto, A., Tomita, S., Imanishi, M., Shioi, G., Kihira, Y., Izawa-Ishizawa, Y.,
Takaku, M., Hashimoto, I., Ikeda, Y., Nakanishi, H. and Tamaki, T. (2014)
Overexpressed HIF-2alpha in Endothelial Cells Promotes Vascularization and Improves
Random Pattern Skin Flap Survival. Plast Reconstr Surg Glob Open 2(4): e132.
Ishiguro, K., Kim, J., Shibuya, H., Hernandez-Hernandez, A., Suzuki, A., Fukagawa, T.,
Shioi, G., Kiyonari, H., Li, X. C., Schimenti, J., Höög, C. and Watanabe, Y. (2014)
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes
Dev 28(6): 594-607.
Hirano, A., Kurabayashi, N., Nakagawa, T., Shioi, G., Todo, T., Hirota, T. and Fukada,
Y. (2014) In vivo role of phosphorylation of cryptochrome 2 in the mouse circadianclock. Mol Cell Biol 34(24): 4464-73.
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y,
Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H,
Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U,
Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y.
(2014) Epac1-dependent hospholamban phosphorylation mediates the cardiac responseto stresses. J Clin Invest. 124(6):2785-2801. doi: 10.1172/JCI64784.

2013
Abe, T. and Fujimori, T. (2013) Reporter mouse lines for fluorescent imaging. Dev
Growth Differ

55(4): 390-405.

Abe, T., Aizawa, S. and Fujimori, T. (2013) Live imaging of early mouse embryos
using fluorescently labeled transgenic mice. Methods Mol Biol 1052: 101-8. doi:
10.1007/7651_2013_20.
Abe, T., Sakaue-Sawano, A., Kiyonari, H., Shioi, G., Inoue, K., Horiuchi, T., Nakao, K.,
Miyawaki, A., Aizawa, S. and Fujimori, T. (2013) Visualization of cell cycle in mouseembryos with Fucci2 reporter directed by Rosa26 promoter. Development 140(1):237-46.
Fujikura, K., Setsu, T., Tanigaki, K., Abe, T., Kiyonari, H., Terashima, T. and Sakisaka,
T. (2013) Kif14 mutation causes severe brain malformation and hypomyelination. PLoS
One 8(1): e53490.
Ikeshima-Kataoka, H., Abe, Y., Abe, T. and Yasui, M. (2013) Immunological functionof aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory
cytokine

inducer,osteopontin.

Mol

Cell

Neurosci.

56:65-75.

doi:

10.1016/j.mcn.2013.02.002.
Tanaka, S., Kawaguchi, S. Y., Shioi, G. and Hirano, T. (2013) Long-term potentiationof inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes toadaptation of vestibulo-ocular reflex. J Neurosci 33(43): 17209-20.
Park, S., Shcheynikov, N., Hong, J. H., Zheng, C., Suh, S. H., Kawaai, K., Ando, H.,
Mizutani, A., Abe, T., Kiyonari, H., Seki, G., Yule, D., Mikoshiba, K. and Muallem, S.
(2013) Irbit mediates synergy between ca(2+) and cAMP signaling pathways during
epithelial transport in mice. Gastroenterology 145(1): 232-41.
Sakaguchi, M., Sharmin, S., Taguchi, A., Ohmori, T., Fujimura, S., Abe, T., Kiyonari,H., Komatsu, Y., Mishina, Y., Asashima, M., Araki, E. and Nishinakamura, R. (2013)
The phosphatase Dullard negatively regulates BMP signalling and is essential for
nephron maintenance after birth. Nat Commun 4: 1398.
Takao, D., Nemoto, T., Abe, T., Kiyonari, H., Kajiura-Kobayashi, H., Shiratori, H. andNonaka, S. (2013) Asymmetric distribution of dynamic calcium signals in the node ofmouse embryo during left-right axis formation. Dev Biol 376(1): 23-30.
Takarada, T., Hinoi, E., Nakazato, R., Ochi, H., Xu, C., Tsuchikane, A., Takeda, S.,
Karsenty, G., Abe, T., Kiyonari, H. and Yoneda, Y. (2013) An analysis of skeletal
development in osteoblast-specific and chondrocyte-specific runt-related transcription
factor-2 (Runx2) knockout mice. J Bone Miner Res 28(10): 2064-9.
Tamaki, M., Fujitani, Y., Hara, A., Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M.,
Watanabe, T., Ogihara, T., Fukunaka, A. Shimizu, T., Mita, T., Kanazawa, A.,
Imaizumi, M. O., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Kawauchi, T.,
Nagamatsu,

S.,

Hirano,T.,

Kawamori,R.

and

Watada,H.

(2013)

The

diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin
Invest 123(10): 4513-24.
Tanaka, S. S., Nakane, A., Yamaguchi, Y. L., Terabayashi, T., Abe, T., Nakao, K.,
Asashima, M., Steiner, K. A., Tam, P. P. and Nishinakamura, R. (2013)
Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial
Germ Cells in the Mouse Embryo. PLoS One 8(3): e57428.
Yagi, H., Nakagawa, N., Saito, T., Kiyonari, H., Abe, T., Toda, T., Wu, S. W., Khoo, K.
H., Oka, S. and Kato, K. (2013) AGO61-dependent GlcNAc modification primes theformation of functional glycans on alpha-dystroglycan. Sci Rep 3: 3288.
Nakashima, A., Takeuchi, H., Imai, T., Saito, H., Kiyonari, H., Abe, T., Chen, M.,
Weinstein, L. S., Yu, C. R., Storm, D. R., Nishizumi, H. and Sakano, H. (2013)
Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory
sensory neurons. Cell 154(6): 1314-25.

Masuda, K., Ripley, B., Nishimura, R., Mino, T., Takeuchi, O., Shioi, G., Kiyonari, H.
and Kishimoto, T. (2013) Arid5a controls IL-6 mRNA stability, which contributes toelevation of IL-6 level in vivo. Proc Natl Acad Sci U S A 110(23): 9409-14.
Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang,W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O.J. and Koh, G.Y. (2013)
Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling
for recovery of ischemic retinopathy. Sci Transl Med 5(203): 203ra127.
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K.,
Kashihara, D., Hirano, K., Tani, T., Takahashi, T., Miyauchi, S., Shioi, G., Inoue, H.
and Tsujimoto, G. (2013) The gut microbiota suppresses insulin-mediated fat
accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 4: 1829. doi:
10.1038/ncomms2852.
Huong le, T., Kobayashi, M., Nakata, M., Shioi, G., Miyachi, H., Honjo, T. andNagaoka, H. (2013) In vivo analysis of Aicda gene regulation: a critical balance
between upstream enhancers and intronic silencers governs appropriate expression.
PLoS One 8(4): e61433.
Matsuo, Y., Irie, K., Kiyonari, H., Okuyama, H., Nakamura, H., Son, A., Lopez-Ramos,
D. A., Tian, H., Oka, S., Okawa, K., Kizaka-Kondoh, S., Masutani, H., Yodoi, J. (2013)
The protective role of the transmembrane thioredoxin-related protein TMX in
inflammatory liver injury. Antioxid Redox Signal 18(11): 1263-72.
Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W. F., Sakamoto,D., Higuchi, Y., Kiyonari, H., Asano, K., Iwakura, Y., Fukumoto, M., Osato, M.,
Sanada, M., Ogawa, S., Nakamura, T. and Satake, M. (2013) Smap1 deficiency perturbs
receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest 123(3):1123-37.
Imuta, Y., Kiyonari, H., Jang, C. W., Behringer, R. R. and Sasaki, H. (2013) Generation

of knock-in mice that express nuclear enhanced green fluorescent protein andtamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis
51(3): 210-8.
Hoshina, N., Tanimura, A., Yamasaki, M., Inoue, T., Fukabori, R., Kuroda, T.,
Yokoyama, K., Tezuka, T., Sagara, H., Hirano, S., Kiyonari, H., Takada, M., Kobayashi,K., Watanabe, M., Kano, M., Nakazawa, T., Yamamoto, T. (2013) Protocadherin 17
regulates presynaptic assembly in topographic corticobasal Ganglia circuits. Neuron
78(5): 839-54.
Tsujino, K., Narumi, R., Masumoto, KH., Susaki, EA., Shinohara, Y., Abe, T., Iigo, M.,
Wada, A., Nagano, M., Shigeyoshi, Y., Ueda, HR. (2013) Establishment of TSH β
real-time monitoring system in mammalian photoperiodism. Genes Cells 18(7):575-588.
Matsuo, Y., Irie, K., Kiyonari, H., Okuyama, H., Nakamura, H., Son, A., Lopez-Ramos,DA., Tian, H., Oka, S., Okawa, K., Kizaka-Kondoh, S., Masutani, H. and Yodoi, J.
(2013) The protective role of transmembrane thioredoxin-related protein TMX in
inflammatory liver injury. Antioxid Redox Signal 18(11): 1263-72.

2012
Ohmura, T., Shioi, G., Hirano, M. and Aizawa, S. (2012) Neural tube defects by
NUAK1 and NUAK2 double mutation. Dev Dyn 241(8): 1350-64.
Tao, H., Inoue, K., Kiyonari, H., Bassuk, A. G., Axelrod, J. D., Sasaki, H., Aizawa, S.
and Ueno, N. (2012) Nuclear localization of Prickle2 is required to establish cell
polarity during early mouse embryogenesis. Dev Biol 364(2): 138-48.
Shinohara, R., Thumkeo, D., Kamijo, H., Kaneko, N., Sawamoto, K., Watanabe, K.,
Takebayashi, H., Kiyonari, H., Ishizaki, T., Furuyashiki, T. and Narumiya, S. (2012) A
role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron
precursors. Nat Neurosci 15(3): 373-80.
Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T.,
Handa, H. and Ito, S. (2012) Identification of NIPSNAP1 as a nocistatin-interacting
protein involving pain transmission. J Biol Chem 287(13): 10403-13.
Kogo, H., Tsutsumi, M., Inagaki, H., Ohye, T., Kiyonari, H. and Kurahashi, H. (2012)
HORMAD2 is essential for synapsis surveillance during meiotic prophase via therecruitment of ATR activity. Genes Cells 17(11): 897-912.
Iwano, T., Masuda, A., Kiyonari, H., Enomoto, H. and Matsuzaki, F. (2012) 'Prox1
postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3
pyramidal cell fate in the hippocampus', Development 139(16): 3051-62.
Sato, S., Ikeda, K., Shioi, G., Nakao, K., Yajima, H. and Kawakami, K. (2012)
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods. Dev
Biol 368(1): 95-108.
Nishimura, R., Wakabayashi, M., Hata, K., Matsubara, T., Honma, S., Wakisaka, S.,
Kiyonari, H., Shioi, G., Yamaguchi, A., Tsumaki, N., Akiyama, H. and Yoneda, T.
(2012) Osterix regulates calcification and degradation of chondrogenic matrices throughmatrix metalloproteinase 13 (MMP13) expression in association with transcription
factor Runx2 during endochondral ossification. J Biol Chem 287(40): 33179-90.
Nakagawa, S., Ip, J. Y., Shioi, G., Tripathi, V., Zong, X., Hirose, T. and Prasanth, K. V.
(2012) Malat1 is not an essential component of nuclear speckles in mice. RNA 18(8):1487-99.
Kanemaru, K., Nakamura, Y., Sato, K., Kojima, R., Takahashi, S., Yamaguchi, M.,
Ichinohe, M., Kiyonari, H., Shioi, G., Kabashima, K., Nakahigashi, K., Asagiri, M.,
Jamora, C., Yamaguchi, H. and Fukami, K. (2012) Epidermal phospholipase Cδ1regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun
3: 963. doi: 10.1038/ncomms1960.
Inazuka, F., Sugiyama, N., Tomita, M., Abe, T., Shioi, G. and Esumi, H. (2012)
Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents
high fat diet-induced glucose intolerance. J Biol Chem 287(20): 16379-89.
Aoyama, K., Wang, F., Matsumura, N., Kiyonari, H., Shioi, G., Tanaka, K., Kinoshita,C., Kikuchi-Utsumi, K., Watabe, M. and Nakaki, T. (2012) Increased neuronal
glutathione and neuroprotection in GTRAP3-18-deficient mice. Neurobiol Dis 45(3):973-82.
Izawa, K., Yamanishi, Y., Maehara, A., Takahashi, M., Isobe, M., Ito, S., Kaitani, A.,
Matsukawa, T., Matsuoka, T., Nakahara, F., Oki, T., Kiyonari, H., Abe, T., Okumura,K., Kitamura, T. and Kitaura, J. (2012) The Receptor LMIR3 Negatively Regulates
Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide.
Immunity 37(5): 827-39.
Niisato, E., Nagai, J., Yamashita, N., Abe, T., Kiyonari, H., Goshima, Y. and Ohshima,
T. (2012) CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in
the mouse hippocampus. Dev Neurobiol 72(11): 1447-57.
Sugimoto, M., Kondo, M., Hirose, M., Suzuki, M., Mekada, K., Abe, T., Kiyonari, H.,

Ogura, A., Takagi, N., Artzt, K. and Abe, K. (2012) Molecular Identification of t(w5):
Vps52 Promotes Pluripotential Cell Differentiation through Cell-Cell Interactions. Cell
Rep 2(5): 1363-74.
Fukuhara, S., Simmons, S., Kawamura, S., Inoue, A., Orba, Y., Tokudome, T., Sunden,Y., Arai, Y., Moriwaki, K., Ishida, J., uemura, A., Kiyonari, H., Abe, T., Fukamizu, A.,
Hirashima, M., Sawa, H., Aoki, J., Ishii, M. and Mochizuki, N. (2012) The
sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates
lymphocyte trafficking in mice. J Clin Invest 122(4): 1416-26.
Nakae, J., Cao, Y., Hakuno, F., Takemori, H., Kawano, Y., Sekioka, R., Abe, T.,
Kiyonari, H., Tanaka, T., Sakai, J., Takahashi, S. and Itoh, H. (2012) Novel repressor
regulates insulin sensitivity through interaction with Foxo1. EMBO J 31(10): 2275-95.
Kogo, H., Tsutsumi, M., Ohye, T., Inagaki, H., Abe, T. and Kurahashi, H. (2012)
HORMAD1-dependent

checkpoint/surveillancemechanism

eliminates

asynaptic

oocytes. Genes Cells 17(6): 439-54.
Konno, D., Iwashita, M., Satoh, Y., Momiyama, A., Abe, T., Kiyonari, H. andMatsuzaki, F. (2012) The Mammalian DM Domain Transcription Factor Dmrta2 Is
Required for Early Embryonic Development of the Cerebral Cortex. PLoS One 7(10):e46577.
Suzuki, M., Tanaka, H., Tanimura, A., Tanabe, K., Oe, N., Rai, S., Kon, S., Fukumoto,M., Takei, K., Abe, T., Matsumura, I., Kanakura, Y. and Watanabe, T. (2012) The
clathrin assembly protein PICALM is required for erythroid maturation and transferrin
internalization in mice. PLoS One 7(2): e31854.

2011
Shioi, G., Kiyonari, H., Abe, T., Nakao, K., Fujimori, T., Jang, C. W., Huang, C. C.,
Akiyama, H., Behringer, R. R. and Aizawa, S. (2011) A mouse reporter line toconditionally mark nuclei and cell membranes for in vivo live-imaging. Genesis 49(7):570-8.
Abe, T., Kiyonari, H., Shioi, G., Inoue, K., Nakao, K., Aizawa, S. and Fujimori, T.
(2011) Establishment of conditional reporter mouse lines at ROSA26 locus for live cell
imaging. Genesis 49(7): 579-90.
Nakagawa, S., Naganuma, T., Shioi, G. and Hirose, T. (2011) Paraspeckles are
subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol 193(1):31-9.
Hara, T., Mimura, K., Abe, T., Shioi, G., Seiki, M. and Sakamoto, T. (2011) Deletion of
the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistanceto lipopolysaccharide-induced septic shock. J Biol Chem 286(37): 32542-51.
Ishikawa, T., Gotoh, N., Murayama, C., Abe, T., Iwashita, M., Matsuzaki, F., Suzuki, T.
and Yamamoto, T. (2011) IgSF molecule MDGA1 is involved in radial migration andpositioning of a subset of cortical upper-layer neurons. Dev Dyn 240(1): 96-107.
Kobayashi, M., Sabouri, Z., Sabouri, S., Kitawaki, Y., Pommier, Y., Abe, T., Kiyonari,
H. and Honjo, T. (2011) Decrease in topoisomerase I is responsible foractivation-induced cytidine deaminase (AID)-dependent somatic hypermutation. Proc
Natl Acad Sci U S A 108(48): 19305-10.
Kuroda, K., Yamada, S., Tanaka, M., Iizuka, M., Yano, H., Mori, D., Tsuboi, D.,
Nishioka, T., Namba, T., Iizuka, Y., Kubota, S., Nagai, T., Ibi, D., Wang, R., Enomoto,A., Isotani-Sakakibara, M., Asai, N., Kimura, K., Kiyonari, H., Abe, T., Mizoguchi, A.,
Sokabe, M., Takahashi, M., Yamada, K. and Kaibuchi, K. (2011) Behavioral alterations
associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

Hum Mol Genet 20(23): 4666-83.
Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T.,
Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J.M.,
Inoue, J., Akiyama, T. and Matsumoto, M. (2011) Lymphotoxin signal promotes thymicorganogenesis by eliciting RANK expression in the embryonic thymic stroma. J
Immunol 186(9): 5047-57.
Sano, T., Kim, Y. J., Oshima, E., Shimizu, C., Kiyonari, H., Abe, T., Higashi, H.,
Yamada, K. and Hirabayashi, Y. (2011) Comparative characterization of GPRC5B and
GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
Biochem Biophys Res Commun 412(3): 460-5.
Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie,
Y., Kawasaki, T., Hirata, T., Abe, T., Kiyonari, H., Strittmatter, SM., Goshima, Y. andTakei, K. (2011) Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor
antagonist for axon tract formation. Science 333(6043): 769-73.
Shibata, M., Nakao, H., Kiyonari, H., Abe, T. and Aizawa, S. (2011) MicroRNA-9
regulates neurogenesis in mouse telencephalon by targeting multiple transcription
factors. J Neurosci 31(9): 3407-22.
Takahashi, M., Okimura, Y., Iguchi, G., Nishizawa, H., Yamamoto, M., Suda, K.,
Kitazawa, R., Fujimoto, W., Takahashi, K., Zolotaryov, F. N., Hong, K. S., Kiyonari, H.,
Abe, T., Kaji, H., Kitazawa, S., Kasuga, M., Chihara, K. and Takahashi, Y. (2011)
Chemerin regulates beta-cell function in mice. Sci Rep 1: 123. doi: 10.1038/srep00123.
Tao, H., Manak, J. R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N. S.,
Yang, T., Wu, S., Chen, S., Fox, M.H., Gurnett, C., Montine, T., Bird, T., Shaffer, L.G.,
Rosenfeld, J.A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H.,
Saneto, R.P., Scott, M.P., Antic, D., Reed, J., Boland, R., Ehaideb, S.N., El-Shanti, H.,
Mahajan, V.B., Ferguson, P.J., Axelrod, J.D., Lehesjoki, A.E., Fritzsch, B., Slusarski,
D.C., Wemmie, J., Ueno, N. and Bassuk, A.G. (2011) Mutations in prickle orthologs

cause seizures in flies, mice, and humans. Am J Hum Genet 88(2): 138-49.
Yabuta, Y., Ohta, H., Abe, T., Kurimoto, K., Chuma, S. and Saitou, M. (2011) TDRD5
isrequiredfor

retrotransposon

silencing,

chromatoid

body

assembly,andspermiogenesis in mice. J Cell Biol 192(5): 781-95.
Yamanaka, Y., Kitano, A., Takao, K., Prasansuklab, A., Mushiroda, T., Yamazaki, K.,
Kumada, T., Shibata, M., Takaoka, Y., Awaya, T., Kato, T., Abe, T., Iwata, N.,
Miyakawa, T., Nakamura, Y., Nakahata, T. and Heike, T. (2011) Inactivation offibroblast growth factor binding protein 3 causes anxiety-related behaviors. Mol Cell
Neurosci 46(1): 200-12.
Zhang, J., Eto, K., Honmyou, A., Nakao, K., Kiyonari, H. and Abe, S. (2011)
Neuregulins are essential for spermatogonial proliferation and meiotic initiation inneonatal mouse testis. Development 138(15): 3159-68.
Yamaguchi, Y. L., Tanaka, S. S., Oshima, N., Kiyonari, H., Asashima, M. andNishinakamura, R. (2011) Translocon-associated protein subunit Trap-gamma/Ssr3 isrequired for vascular network formation in the mouse placenta. Dev Dyn 240(2):394-403.
Kamiya, D., Banno, S., Sasai, N., Ohgushi, M., Inomata, H., Watanabe, K., Kawada, M.,
Yakura, R., Kiyonari, H., Nakao, K., Jakt, L.M., Nishikawa, S. and Sasai, Y. (2011)
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors.
Nature 470(7335): 503-9.
Inoue, Y., Tashiro-Yamaji, J., Hayashi, M., Kiyonari, H., Shimizu, T., Ibata, M.,
Yamana, H., Kubota, T., Tanigawa, N. and Yoshida, R. (2011) Transgene
number-dependent, gene expression rate-independent rejection of Dd -, Kd-, or Dd Kd-transgened mouse skin or tumor cells from C57BL/6 Db Kb mice. Microbiol Immunol
55(6): 446-53.

2010
Nakao, K. and Inoue, K. (2010) Cryopreservation for Broader Production of Transgenic
Mice by DNA Injection into Zygotes. Exp Anim 59(2): 225-9.
Kiyonari, H., Kaneko, M., Abe, S. and Aizawa, S. (2010) Three inhibitors of FGF
receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of
C57BL/6N mouse strain with high efficiency and stability. Genesis 48(5): 317-27.
Uchiyama, Y., Sakaguchi, M., Terabayashi, T., Inenaga, T., Inoue, S., Kobayashi, C.,
Oshima, N., Kiyonari, H., Nakagata, N., Sato, Y., Sekiguchi, K., Miki, H., Araki, E.,
Fujimura, S., Tanaka, SS. and Nishinakamura, R. (2010) Kif26b, a kinesin family gene,
regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A
107(20): 9240-5.
Sakurai, Y., Kurokawa, D., Kiyonari, H., Kajikawa, E., Suda, Y. and Aizawa, S. (2010)
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into
metencephalon during early brain regionalization. Dev Biol 347(2): 392-403.
Kanemaru, K., Nakahara, M., Nakamura, Y., Hashiguchi, Y., Kouchi, Z., Yamaguchi,
H., Oshima, N., Kiyonari, H. and Fukami, K. (2010) Phospholipase C-eta2 is highly
expressed in the habenula and retina. Gene Expr Patterns 10(2-3): 119-26.
Chandana, E. P., Maeda, Y., Ueda, A., Kiyonari, H., Oshima, N., Yamamoto, M.,
Kondo, S., Oh, J., Takahashi, R., Yoshida, Y., Kawashima, S., Alexander, D.B.,
Kitayama, H., Takahashi, C., Tabata, Y., Matsuzaki, T. and Noda, M. (2010)
Involvement of the Reck tumor suppressor protein in maternal and embryonic vascularremodeling in mice. BMC Dev Biol 10: 84. doi: 10.1186/1471-213X-10-84.
Sato, S., Ikeda, K., Shioi, G., Ochi, H., Ogino, H., Yajima, H. and Kawakami, K. (2010)
Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identificationof an enhancer for the rostral PPR. Dev Biol 344(1): 158-71.

Ito, A., Shinmyo, Y., Abe, T., Oshima, N., Tanaka, H. and Ohta, K. (2010) Tsukushi isrequired for anterior commissure formation in mouse brain. Biochem Biophys Res
Commun 402(4): 813-8.
Kumada, T., Yamanaka, Y., Kitano, A., Shibata, M., Awaya, T., Kato, T., Okawa, K.,
Abe, T., Oshima, N., Nakahata, T. and Heike, T. (2010) Ttyh1, a Ca(2+)-binding
protein localized to the endoplasmic reticulum, is required for early embryonicdevelopment. Dev Dyn 239(8): 2233-45.
Oboki, K., Ohno, T., Kajiwara, N., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T.,
Kiyonari, H., Matsumoto, K., Sudo, K., Okumura, K., Saito, H. and Nakae, S. (2010)
IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci
U S A 107(43): 18581-6.
Tanabe, K., Kani, S., Shimizu, T., Bae, Y. K., Abe, T. and Hibi, M. (2010) Atypical
protein kinase C regulates primary dendrite specification of cerebellar Purkinje cells by
localizing Golgi apparatus. J Neurosci 30(50): 16983-92.
Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M.,
Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., Abe, T., Komori, T., Morikawa, Y.,
Kiyonari, H., Takai, T., Okumura, K. and Kitamura, T. (2010) TIM1 is an endogenous
ligandfor

LMIR5/CD300b:

LMIR5

deficiency

ameliorates

mouse

kidneyischemia/reperfusion injury. J Exp Med 207(7): 1501-11.
Suzuki, S., Yokoyama, U., Abe, T., Kiyonari, H., Yamashita, N., Kato, Y., Kurotani, R.,
Sato, M., Okumura, S. and Ishikawa, Y. (2010) Differential roles of Epac in regulatingcell death inneuronal and myocardial cells. J Biol Chem 285(31): 24248-59.

2009
Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann,
D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto,M., Ohtani, N. and Hara, E. (2009) Real-time in vivo imaging of p16Ink4a reveals
cross-talk with p53. J Cell Biol 186(3): 393-407.
Ukita, K., Hirahara, S., Oshima, N., Imuta, Y., Yoshimoto, A., Jang, C.W., Oginuma,
M., Saga, Y., Behringer, R.R., Kondoh, H. and Sasaki, H. (2009) Wnt signaling
maintains the notochord fate for progenitor cells and supports the posterior extension of
the notochord. Mech Dev 126(10): 791-803.
Okuyama, H., Yoshida, T., Son, A., Oka, S., Wang, D., Nakayama, R., Masutani, H.,
Nakamura, H., Nabeshima, Y. and Yodoi, J. (2009) Thioredoxin binding protein 2
modulates natural killer T cell-dependent innate immunity in the liver: possible link tolipid metabolism. Antioxid Redox Signal. 11(10): 2585-93.
Kato, M., Hasunuma, N., Manabe, M., Nakayama, R., Takeda, J., Itami, S., Taira, M.
and Osada, S. (2009) Progranulin, a secreted tumorigenesis and dementia-related factor,
regulates mouse hair growth. J Dermatol Sci 53(3): 234-6.
Hamada, S., Hara, K., Hamada, T., Yasuda, H., Moriyama, H., Nakayama, R., Nagata,
M. and Yokono, K. (2009) Upregulation of the mammalian target of rapamycincomplex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads toincreased beta-cell mass and prevention of hyperglycemia. Diabetes 58(6): 1321-32.
Fukatsu, Y., Noguchi, T., Hosooka, T., Ogura, T., Kotani, K., Abe, T., Shibakusa, T.,
Inoue, K., Sakai, M., Tobimatsu, K., Inagaki, K., Yoshioka, T., Matsuo, M., Nakae, J.,
Matsuki, Y., Hiramatsu, R., Kaku, K., Okamura, H., Fushiki, T. and Kasuga, M. (2009)
Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth
factor increases peripheral glucose disposal and insulin sensitivity. Endocrinology
150(6): 2683-91.

Imai, T., Yamazaki, T., Kobayakawa, R., Kobayakawa, K., Abe, T., Suzuki, M. and
Sakano, H. (2009) Pre-target axon sorting establishes the neural map topography.
Science 325(5940): 585-90.
Islam, S. M., Shinmyo, Y., Okafuji, T., Su, Y., Naser, I. B., Ahmed, G., Zhang, S.,
Chen, S., Ohta, K., Kiyonari, H., Abe, T., Tanaka, S., Nishinakamura, R., Terashima, T.,
Kitamura, T. and Tanaka, H. (2009) Draxin, a repulsive guidance protein for spinal cordand forebrain commissures. Science 323(5912): 388-93.
Oda, H., Fujimoto, M., Patrick, M. S., Chida, D., Sato, Y., Azuma, Y., Aoki, H., Abe,T., Suzuki, H. and Shirai, M. (2009) RhoH plays critical roles in Fc epsilon
RI-dependent signal transduction in mast cells. J Immunol 182(2): 957-62.
Patrick, M. S., Oda, H., Hayakawa, K., Sato, Y., Eshima, K., Kirikae, T., Iemura, S.,
Shirai, M., Abe, T., Natsume, T., Sasazuki, T. and Suzuki, H. (2009) Gasp, a
Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad
Sci U S A 106(38): 16345-50.
Tao, H., Suzuki, M., Kiyonari, H., Abe, T., Sasaoka, T. and Ueno, N. (2009) Mouse
prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc
Natl Acad Sci U S A 106(34): 14426-31.
Watanabe, N., Hiramatsu, K., Miyamoto, R., Yasuda, K., Suzuki, N., Oshima, N.,
Kiyonari, H., Shiba, D., Nishio, S., Mochizuki, T., Yokoyama, T., Maruyama, S.,
Matsuo, S., Wakamatsu, Y. and Hashimoto, H. (2009) A murine model of neonatal
diabetes mellitus in Glis3-deficient mice. FEBS Lett 583(12): 2108-13.
Ohno, M., Hiraoka, Y., Matsuoka, T., Tomimoto, H., Takao, K., Miyakawa, T., Oshima,N., Kiyonari, H., Kimura, T., Kita, T. and Nishi, E. (2009) Nardilysin regulates axonal
maturation and myelination in the central and peripheral nervous system. Nat Neurosci
12(12): 1506-13.
Noguchi, Y., Hirabayashi, T., Katori, S., Kawamura, Y., Sanbo, M., Hirabayashi, M.,Kiyonari, H., Nakao, K., Uchimura, A. and Yagi, T. (2009) Total expression and dual
gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha
cluster. J Biol Chem 284(46): 32002-14.
Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N.,
Hirahara, S., Stephenson, R. O., Ogonuki, N., Makita, R., Kurihara, H., Morin-Kensicki,
E.M., Nojima, H., Rossant, J., Nakao, K., Niwa, H. and Sasaki, H. (2009) The Hippo
signaling pathway components Lats and Yap pattern Tead4 activity to distinguishmouse trophectoderm from inner cell mass. Dev Cell 16(3): 398-410.
Nishide, K., Nakatani, Y., Kiyonari, H. and Kondo, T. (2009) Glioblastoma formationfrom cell population depleted of Prominin1-expressing cells. PLoS One 4(8): e6869.
Imuta, Y., Nishioka, N., Kiyonari, H. and Sasaki, H. (2009) Short limbs, cleft palate,and delayed formation of flat proliferative chondrocytes in mice with targeted
disruption of a putative protein kinase gene, Pkdcc (AW548124). Dev Dyn 238(1):210-22.

2008
Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W.,
Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S.,
Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T.,
Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T. andKasuga, M. (2008) FSP27 contributes to efficient energy storage in murine white
adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118(8):2808-21.
Nakamura, K., Ichise, H., Nakao, K., Hatta, T., Otani, H., Sakagami, H., Kondo, H. and
Katsuki, M. (2008) Partial functional overlap of the three ras genes in mouse embryonicdevelopment. Oncogene 27(21): 2961-8.
Yamanaka, Y., Heike, T., Kumada, T., Shibata, M., Takaoka, Y., Kitano, A., Shiraishi,K., Kato, T., Nagato, M., Okawa, K., Furushima, K., Nakao, K., Nakamura, Y., Taketo,
M.M., Aizawa, S. and Nakahata, T. (2008) Loss of Borealin/DasraB leads to defective
cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 125(5-6):
441-50.
Konno, D., Shioi, G., Shitamukai, A., Mori, A., Kiyonari, H., Miyata, T. and Matsuzaki,
F. (2008) Neuroepithelial progenitors undergo LGN-dependent planar divisions tomaintain self-renewability during mammalian neurogenesis. Nat Cell Biol 10(1):93-101.
Yano, M., Kuroda, N., Han, H., Meguro-Horike, M., Nishikawa, Y., Kiyonari, H.,
Maemura, K., Yanagawa, Y., Obata, K., Takahashi, S., Ikawa, T., Satoh, R., Kawamoto,H., Mouri, Y. and Matsumoto, M. (2008) Aire controls the differentiation program ofthymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med
205(12): 2827-38.
Tamai, K., Toyoshima, M., Tanaka, N., Yamamoto, N., Owada, Y., Kiyonari, H.,
Murata, K., Ueno, Y., Ono, M., Shimosegawa, T., Yaegashi, N., Watanabe, M. andSugamura, K. (2008) Loss of hrs in the central nervous system causes accumulation ofubiquitinated proteins and neurodegeneration. Am J Pathol 173(6): 1806-17.
Takasato, M., Kobayashi, C., Okabayashi, K., Kiyonari, H., Oshima, N., Asashima, M.
and Nishinakamura, R. (2008) Trb2, a mouse homolog of tribbles, is dispensable forkidney and mouse development. Biochem Biophys Res Commun 373(4): 648-52.
Suzuki, A., Sekiya, S., Onishi, M., Oshima, N., Kiyonari, H., Nakauchi, H. andTaniguchi, H. (2008) Flow cytometric isolation and clonal identification ofself-renewing bipotent hepatic progenitor cells in adult mouse liver. Hepatology 48(6):1964-78.
Sawada, A., Kiyonari, H., Ukita, K., Nishioka, N., Imuta, Y. and Sasaki, H. (2008)
Redundant roles of Tead1 and Tead2 in notochord development and the regulation ofcell proliferation and survival. Mol Cell Biol 28(10): 3177-89.
Nishioka, N., Yamamoto, S., Kiyonari, H., Sato, H., Sawada, A., Ota, M., Nakao, K.
and Sasaki, H. (2008) 'Tead4 is required for specification of trophectoderm in
pre-implantation mouse embryos', Mech Dev 125(3-4): 270-83.
Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K.,
Lombes, M. and Hayashi, Y. (2008)'Forkhead transcription factor FoxO1 in adipose
tissue regulates energy storage and expenditure. Diabetes 57(3): 563-76.
Matsumoto, M., Zhou, Y., Matsuo, S., Nakanishi, H., Hirose, K., Oura, H., Arase, S.,
Ishida-Yamamoto, A., Bando, Y., Izumi, K., Kiyonari, H., Oshima, N., Nakayama, R.,
Matsushima, A., Hirota, F., Mouri, Y., Kuroda, N., Sano, S. and Chaplin, D.D. (2008)
Targeted deletion of the murine corneodesmosin gene delineates its essential role inskin and hair physiology. Proc Natl Acad Sci U S A 105(18): 6720-4.
Kousaka, K., Kiyonari, H., Oshima, N., Nagafuchi, A., Shima, Y., Chisaka, O. andUemura, T. (2008) Slingshot-3 dephosphorylates ADF/cofilin but is dispensable formouse development. Genesis 46(5): 246-55.

Aoki, M., Kiyonari, H., Nakamura, H. and Okamoto, H. (2008) R-spondin2 expression
in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb
development. Dev Growth Differ 50(2): 85-95.
Seino, Y., Miki, T., Kiyonari, H., Abe, T., Fujimoto, W., Kimura, K., Takeuchi, A.,
Takahashi, Y., Oiso, Y., Iwanaga, T. and Seino, S. (2008) Isx participates in themaintenanceofvitaminA

metabolism

byregulationofbeta-carotene

15,15'-monooxygenase (Bcmo1) expression. J Biol Chem 283(8): 4905-11.
Shigetani, Y., Howard, S., Guidato, S., Furushima, K., Abe, T. and Itasaki, N. (2008)
Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal
region during head development. Dev Biol 319(2): 346-58.

2007
Furushima, K., Yamamoto, A., Nagano, T., Shibata, M., Miyachi, H., Abe, T., Ohshima,N., Kiyonari, H. and Aizawa, S. (2007) Mouse homologues of Shisa antagonistic to
Wnt and Fgf signalings. Dev Biol 306(2): 480-92.
Kurotaki, Y., Hatta, K., Nakao, K., Nabeshima, Y. and Fujimori, T. (2007) Blastocyst
Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape.
Science 316(5825): 719-23.
Ogawa, M., Miyakawa, T., Nakamura, K., Kitano, J., Furushima, K., Kiyonari, H.,
Nakayama, R., Nakao, K., Moriyoshi, K. and Nakanishi, S. (2007) Altered sensitivities
to morphine and cocaine in scaffold protein tamalin knockout mice. Proc Natl Acad Sci
U S A 104(37): 14789-94.
Fujishima, K., Kiyonari, H., Kurisu, J., Hirano, T. and Kengaku, M. (2007) Targeted
disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has noeffect on developing CNS neurons. J Neurochem 102(1): 77-92.
Chan, T., Kondow, A., Hosoya, A., Hitachi, K., Yukita, A., Okabayashi, K., Nakamura,
H., Ozawa, H., Kiyonari, H., Michiue, T., Ito, Y. and Asashima, M. (2007) Ripply2 isessential for precise somite formation during mouse early development. FEBS Lett
581(14): 2691-6.
Sugiyama, D., Ogawa, M., Nakao, K., Osumi, N., Nishikawa, S., Nishikawa, S., Arai,
K., Nakahata, T. and Tsuji, K. (2007) B cell potential can be obtained frompre-circulatory yolk sac, but with low frequency. Dev Biol 301(1): 53-61.
Yana, I., Sagara, H., Takaki, S., Takatsu, K., Nakamura, K., Nakao, K., Katsuki, M.,
Taniguchi, S., Aoki, T., Sato, H., Weiss, S.J., Seiki, M. (2007) Crosstalk between
neovessels and mural cells directs the site-specific expression of MT1-MMP to
endothelial tip cells. J Cell Sci 120: 1607-1614.

Aiba, A., Inokuchi, K., Ishida, Y., Itohara, S., Kobayashi, K., Masu, M., Mishina, M.,
Miyakawa, T., Mori, H., Nakao, K., Obata, Y., Sakimura, K., Shiroishi, T., Wada, K.
and Yagi, T. (2007) Mouse liaison for integrative brain research. Neurosci Res 58(2):103-4.
Wei, P., Satoh, T., Edamatsu, H., Aiba, A., Setsu, T., Terashima, T., Kitazawa, S.,
Nakao, K., Yoshikawa, Y., Tamada, M. and Kataoka, T. (2007) Defective vascularmorphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.
Biochem Biophys Res Commun 363(1): 106-12.
Sakata, D., Taniguchi, H., Yasuda, S,. Adachi-Morishima,A., Hamazaki, Y., Nakayama,R., Miki, T., Minato, N. and Narumiya, S. (2007) Impaired T lymphocyte trafficking
in mice deficient in an actin-nucleating protein, mDia1. J Exp Med 204(9): 2031-8.
Takasaki, N., Kurokawa, D., Nakayama, R., Nakayama, J. and Aizawa, S. (2007)
Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90
kb apart. EMBO J 26(6): 1649-59.
Takashima, Y., Era, T., Nakao, K., Kondo, S., Kasuga, M., G.Smith, Austin. andNishikawa, S. (2007) Neuroepithelial Cells Supply an Initial Transient Wave of MSC
Differentiation. Cell 129(7): 1377-88.
Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, Chu-Xia. and Kageyama, R.
(2007) The Initiation and Propagation of Hes7 Oscillation Are Cooperatively Regulated
by Fgf and Notch Signaling in the Somite Segmentation Clock. Dev Cell. 13(2):298-304.
Nakao, H., Nakao, K., Kano, M. and Aiba, A. (2007) Metabotropic glutamate receptor
subtype-1 is essential for motor coordination in the adult cerebellum. Neurosci Res
57(4): 538-43.
Yoshikawa, Y., Satoh, T., Tamura, T., Wei, P., Bilasy, S E., Edamatsu, H., Aiba, A.,
Katagiri,K.,

KinashiT.,

Nakao,

K.

and

Kataoka,T.

(2007)TheM-Ras-RA-GEF-2-Rap1 Pathway Mediates Tumor Necrosis Factor-α-dependent
Regulation of Integrin Activation in Splenocytes. Mol Bio Cell 18(8): 2949-59.
Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru,N., Takahashi, A., Hirao, A., Shimizu, T., David J. Mann, Saya, H., Hayashi, Y., Arase,S., Matsumoto, M., Nakao, K., and Hara, E. (2007) Visualizing the dynamics of
p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals. Proc Natl
Acad Sci USA 104(38): 15034-9.

2006
Kurokawa, D., Sakurai,Y., Inoue,A., Nakayama,R., Takasaki,N., Suda, Y., Miyake,T.,
Chris T.Amemiya. and Aizawa, S. (2006) Evolutionary constraint on Otx2
neuroectoderm enhancers-deep conservation from skate to mouse and uniquedivergence in teleost. Proc Natl Acad Sci USA 103(51): 19350-5.
Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y. andHibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons regulates
development of the olfactory bulb non-cell-autonomously. Development 133(8):1433-43.
Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y. and Hibi, M. (2006)
Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon
subdivisions. Development 133: 3993-4004.
Oda, M., Yamagiwa, A., Yamamoto, S., Nakayama, T., Tsumura, A., Sasaki, H., Nakao,
K., Li, E. and Okano, M. (2006) DNA methylation regulates long-range gene silencing
of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev 20(24):3382-94.
Sakaguchi, T., Nishimoto, M., Miyagi, S., Iwama, A., Morita, Y., Iwamori, N.,
Nakauchi, H., Kiyonari, H., Muramatsu, M. and Okuda, A. (2006) Putative "stemness"gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or
hematopoietic stem cells. Mol Cell Biol 26(17): 6557-70.
Mazaki, Y., Hashimoto, S., Tsujimura, T., Morishige, M., Hashimoto, A., Aritake, K.,
Yamada, A., Nam, J. M., Kiyonari, H., Nakao, K. and Sabe, H. (2006) Neutrophil
direction sensing and superoxide production linked by the GTPase-activating protein
GIT2. Nat Immunol 7(7): 724-31.
Ikeya, M., Kawada, M., Kiyonari, H., Sasai, N., Nakao, K., Furuta, Y. and Sasai, Y.
(2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.

Development 133(22): 4463-73.
Hirano, M., Kiyonari, H., Inoue, A., Furushima, K., Murata, T., Suda, Y. and Aizawa, S.
(2006) A new serine/threonine protein kinase, Omphk1, essential to ventral body wall
formation. Dev Dyn 235(8): 2229-37.
Hirai, S., Cui de, F., Miyata, T., Ogawa, M., Kiyonari, H., Suda, Y., Aizawa, S., Banba,
Y. and Ohno, S. (2006) The c-Jun N-terminal kinase activator dual leucine zipper
kinase regulates axon growth and neuronal migration in the developing cerebral cortex.
J Neurosci 26(46): 11992-2002.

2005
Furushima, K., Murata, T., Kiyonari, H. and Aizawa, S. (2005) Characterization of Opr
deficiency in mouse brain: subtle defects in dorsomedial telencephalon andmedioventral forebrain. Dev Dyn 232(4): 1056-61.
Terada, K., Yomogida, K., Imai, T., Kiyonari, H., Takeda, N., Kadomatsu, T., Yano, M.,
Aizawa, S. and Mori, M. (2005) A type I DnaJ homolog, DjA1, regulates androgen
receptor signaling and spermatogenesis. EMBO J 24(3): 611-22.
Nishioka, N., Nagano, S., Nakayama, R., Kiyonari, H., Ijiri, T., Taniguchi, K., Shawlot,
W., Hayashizaki, Y., Westphal, H., Behringer, R. R., Matsuda, Y., Sakoda, S., Kondoh,
H. and Sasaki, H. (2005) Ssdp1 regulates head morphogenesis of mouse embryos byactivating the Lim1-Ldb1 complex. Development 132(11): 2535-46.
Ikeya, M., Kawada, M., Nakazawa, Y., Sakuragi, M., Sasai, N., Ueno, M., Kiyonari, H.,
Nakao, K. and Sasai, Y. (2005) Gene disruption/knock-in analysis of mONT3: vector
construction by employing both in vivo and in vitro recombinations. Int J Dev Biol
49(7): 807-23.
Hirano, M., Murata, T., Furushima, K., Kiyonari, H., Nakamura, M., Suda, Y. andAizawa, S. (2005) cfm is a novel gene uniquely expressed in developing forebrain andmidbrain, but its null mutant exhibits no obvious phenotype. Gene Expr Patterns 5(3):439-44.
Kimura, J., Suda, Y., Kurokawa, D., Houssain, ZM., Nakamura, M., Takahashi, M.,
Hara, A. and Aizawa, S. (2005) Emx2 and Pax6 Function in Cooperation with Otx2 andOtx1 to Develop Caudal Forebrain Primordium That Includes Future Archip-allium. J
Neurosci 25(21): 5097-108.
Tomemori, Y., Ichiba, M., Kusumoto, A., Mizuno, E., Sato, D., Muroya, S., Nakamura,M., Kawaguchi, H., Yoshida, H., Ueno, S., Nakao, K., Nakamura, K., Aiba, A., Katsuki,
M. and Sano, A. (2005) A gene-targeted mouse model for chorea-acanthocytosis. J

Neurochem 92(4): 759-66.
Kassai, H., Aiba, A., Nakao, K., Nakamura, K., Katsuki, M., Xiong, WH., Yau, KW.,
Imai, H., Shichida, Y., Satomi, Y., Takao, T., Okano, T. and Fukada, Y. (2005)
Farnesylation of Retinal Transducin Underlies Its Translocation during Light
Adaptation. Neuron 47(4): 529-39.
Hara, T., Saito, Y., Hirai, T., Nakamura, K., Nakao, K., Katsuki, M. and Chida, K.
(2005) Deficiency of protein kinase Calpha in mice results in impairment of epidermal
hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
Cancer Res. 65(16): 7356-62.
Hiratsuka, S., Nakao, K., Nakamura, K., Katsuki, M., Maru, Y. and Shibuya, M. (2005)
Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding
domain is important for vasculogenesis and angiogenesis in mice. Mol Cell Biol 25(1):346-54.
Hiratsuka, S., Kataoka, Y., Nakao, K., Nakamura, K., Morikawa, S., Tanaka, S.,
Katsuki, M., Maru ,Y. and Shibuya, M. (2005) Vascular endothelial growth factor A(VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior
portion of early embryos. Mol Cell Biol 25(1): 355-63.
Sawada, A., Nishizaki, Y., Sato, H., Yada, Y., Nakayama, R., Yamamoto, S., Nishioka,N., Kondoh, H. and Sasaki H. (2005) Tead proteins activate the Foxa2 enhancer in thenode in cooperation with a second factor. Development 132(21): 4719-29.
Kimura-Yoshida, C., Nakano, H., Okamura, D., Nakao, K., Yonemura, S., Belo, J.A.,
Aizawa, S., Matsui, Y. and Matsuo, I. (2005) Canonical Wnt signaling and its
antagonist regulate anterior-posterior axis polarization by guiding cell migration inmouse visceral endoderm. Dev Cell 9(5): 639-50.
Saitsu, H., Komada, M., Suzuki, M., Nakayama, R., Motoyama, J., Shiota, K. and
Ishibashi, M. (2005) Expression of the mouse Fgf15 gene is directly initiated by Sonic

hedgehog signaling in the diencephalon and midbrain. Dev Dyn 232(2): 282-92.
Tada, S., Era, T., Furusawa, C., Sakurai, H., Nishikawa, S., Kinoshita, M., Nakao, K.,
Chiba, T. and Nishikawa, S. (2005) Characterization of mesendoderm: a diverging pointof the definitive endoderm and mesoderm in embryonic stem cell differentiation culture.
Development 132(19): 4363-74.

2004
Okita, K., Kiyonari, H., Nobuhisa, I., Kimura, N., Aizawa, S. and Taga, T. (2004)
Targeted disruption of the mouse ELYS gene results in embryonic death at
peri-implantation development. Genes Cells 9(11): 1083-91.
Murata, T., Furushima, K., Hirano, M., Kiyonari, H., Nakamura, M., Suda, Y. andAizawa, S. (2004) ang is a novel gene expressed in early neuroectoderm, but its nullmutant exhibits no obvious phenotype. Gene Expr Patterns 5(2): 171-8.
Kurokawa, D., Takasaki, N., Kiyonari, H., Nakayama, R., Kimura-Yoshida, C., Matsuo,
I. and Aizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse
epiblast and anterior neuroectoderm. Development 131(14): 3307-17.
Kurokawa, D., Kiyonari, H., Nakayama, R., Kimura-Yoshida, C., Matsuo, I. andAizawa, S. (2004) Regulation of Otx2 expression and its functions in mouse forebrain
and midbrain. Development 131(14): 3319-31.
Sato, M., Tabata, T., Hashimoto, K., Nakamura, K., Nakao, K., Katsuki, M., Kitano, J.,
Moriyoshi, K., Kano, M. and Nakanishi, S. (2004) Altered agonist sensitivity anddesensitization of neuronal mGluR1 responses in knock-in mice by a single amino acidsubstitution at the PKC phosphorylation site. Eur J Neurosci 20(4): 947-55.
Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T. and Hibi, M. (2004) Zincfinger gene fez-like functions in the formation of subplate neurons and thalamocorticalaxons. Dev Dyn 230(3): 546-56.

2003
Terada, K., Ueno, S., Yomogida, K., Imai, T., Kiyonari, H., Takeda, N., Yano, M., Abe,S., Aizawa, S. and Mori, M. (2003) Expression of Tom34 splicing isoforms in mouse
testis and knockout of Tom34 in mice. J Biochem 133(5): 625-31.
Chida, K., Hara, T., Hirai, T., Konishi, C., Nakamura, K., Nakao, K., Aiba, A., Katsuki,
M. and Kuroki, T. (2003) Disruption of protein kinase Ceta results in impairment ofwound healing and enhancement of tumor formation in mouse skin carcinogenesis.
Cancer Res 63(10): 2404-8.
Takaki, S., Tezuka, Y., Sauer, K., Kubo, C., Kwon, SM., Armstead, E., Nakao, K.,
Katsuki, M., Perlmutter, RM. and Takatsu, K. (2003) Impaired lymphopoiesis andaltered B cell subpopulations in mice overexpressing Lnk adaptor protein. J Immunol
170(2): 703-10.