࡟࡞ࡗ࡚ࡁࡓࠋ

ἙὊἑૠྸᄂᆮЎ᣼ᙜヱ◊✲ศ㔝࡛ࡣࠊ໬Ꮫ཯ᛂࡸ⏕యศᏊࡢᵓ㐀㌿⛣࡞࡝ࡢ≧ែኚ໬࡟࠾ࡅࡿࠕഅ↛࡜ᚲ↛ࠖࠊࠕ⤫ィᛶ࡜㑅ᢥᛶࠖࠊ
ࠕ㒊

ᩍ

ᤵ

෸ᩍᤵ

ᑠᯇᓮẸᶞ㸦2007.10㹼㸧

ศ࡜඲యࠖࡢᇶ♏ཎ⌮ࢆゎ᫂ࡍࡿ࡜࡜ࡶ࡟ࠊ
͆ࢺࢵࣉࢲ͇࢘ࣥ

Chun Biu Li㸦2008.3㹼2016.9㸧

࡜͆࣎ࢺ࣒࢔ࢵࣉ͇ࡢ୧࢔ࣉ࣮ࣟࢳࢆᶫΏࡋࡍࡿᴫᛕࡸ᪉

*2016.10㹼ࠊStockholm Universityࠊ෸ᩍᤵἲㄽࢆ☜❧ࡋࠊ࡛ࡁࡿࡔࡅ⮬↛⌧㇟࡟↷ࡽࡋྜࢃࡏ࡞ࡀࡽ෸ᩍᤵ ᑎᮏ

ኸ㸦2017.4㹼㸧

⏕࿨ࢩࢫࢸ࣒ࡢ㝵ᒙᛶࡢㄽ⌮ࢆᵓᡂࡋࠊ⏕࿨ࡢ୰࡟✚ᮌ⣽

ຓ

ᩍ ఀ⸨

๰♸㸦2017.4㹼㸧

ᕤࢆࡇ࠼ࡿ᪂ࡋ࠸ᴫᛕࢆ๰ฟࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋຓᩍ すᮧ࿃ᮁ㸦2007.10㹼㸧≉௵ຓᩍࡇࡢ௚ࠊ༢୍ศᏊศගࢆ⏝࠸ࡓ⏕యィ

ࢆ㏻ࡋ࡚ࠊ㝵ᒙ

James N. Taylor㸦2014.10㹼㸧ࢆ㉺࠼ࡓᵓ㐀࡜ᶵ⬟ࡢ┦㛵ࢆ᥈ࡗ࡚࠸ࡿࠋලయⓗ࡟ࡣࠊ700ὠᕝᬡ㸦2015.9㹼2016.9㸧

㹼1400 nmࡢ㏆㉥እἼ㛗㡿ᇦࡢගィ

*2017.2㹼ࠊ⌮໬Ꮫ◊✲ᡤࠊᇶ♏≉ู◊✲ဨィ

Preetom Nag㸦2016.5㹼2017.3㸧

ࢆ☜❧ࡍࡿࠋࡑࢀ࡟ࡼࡾࠊ༢୍ศᏊࣞ࣋ࣝ࠿ࡽಶయࣞ࣋ࣝ

*2018.1㹼ࠊNorth South Universityࠊຓᩍࡲ࡛ࡢ㝵ᒙࢆࡲࡓ࠸ࡔ⥲ྜⓗ⌮ゎࢆ┠ᣦࡋ࡚࠸ࡿࠋ

ᢏ⾡ࢆ⏝࠸ࡓ㠀౵く࡟ࡼࡾࠊ⏕ࡁࡓࡲࡲࡢ⏕య⤌⧊ࡢᐃ㔞ⓗ⏕యィ ᢏ⾡⏣⏿බḟ㸦2017.7㹼㸧
≉௵ㅮᖌ

Jason Roger Green㸦2017.6ࠥ2017.8㸧
*University of Massachusetts Bostonࠊຓᩍྂᕝ኱௓㸦2012.4㹼2015.10㸧

㸦1㸧཯ᛂᗙᶆษࡾ᭰࠼ᶵᵓࡢᐇ㦂ⓗ᳨ド࡟ྥࡅ࡚

Kernel Enrique Prieto Moreno (2015.8ࠥ

[ ᑎ ᮏ ࡽ PRL 106, 054101 (2011); ᑎ ᮏ ࡽ PRL 115,

༤ኈ◊✲ဨ

093003(2015)]࡟ࡼࡗ࡚ᥦ᱌ࡉࢀࡓࠊࠕศᏊࡢ࢚ࢿࣝࢠ࣮ࢆ

2017.5)
Sulimon Sarrari㸦2017.7㹼㸧ୖࡆ࡚࠸ࡃ࡜ࠊศᏊࡢ཯ᛂᗙᶆࡀ࣏ࢸࣥࢩࣕࣝࡢᙧ≧࠿ࡽᅵ⏣ ᪫㸦2017.12㹼㸧Ỵࡲࡿᴟ㝈཯ᛂᗙᶆࡢ᪉ྥ࠿ࡽࠊูࡢ᪉ྥ࡬࡜୙㐃⥆࡟ษ

Ꮫ⾡◊✲ဨ
Ꮫ

≕≑ᄂᆮ঺ௐ‒ࡾ᭰ࢃࡿ᪂つ཯ᛂᶵᵓࠖࡢᐇ㦂ⓗ᳨ドྍ⬟ᛶࢆ᳨ウࡋࡓࠋ⏕㸦ᖹᡂ27ᖺ4᭶㹼⌧ᅾ㸧༤ኈㄢ⛬ᚋᮇ 6ྡᐇ㦂ⓗ᳨ドࡢࡓࡵ࡟㑅ࢇࡔ⣔ࡣ┤஺ࡍࡿ㟁ሙ☢ሙ୰ࡢỈ⣲Ꮫ㒊⏕ 3ྡ

ཎᏊ࡛࠶ࡿࠋᡃࠎࡣࡇࡢ⣔ࢆ୕ࡘࡢほⅬ࠿ࡽ㑅ࢇࡔࠋ୍ࡘ
┠ࡣ཯ᛂᗙᶆษࡾ᭰࠼ᶵᵓࡀ㉳ࡇࡿࡓࡵ࡟ᚲせ᭱ᑠ㝈ᚲせ࡞㸱⮬⏤ᗘࢆᣢࡘࢩࣥࣉࣝ࡞⣔࡛࠶ࡿࡇ࡜ࠊ஧ࡘ┠ࡣࡇࡢ≔≑ᄂᆮႸ೅‒⣔ࡣࢫࢣ࣮ࣜࣥࢢ๎ࢆ‶ࡓࡋࠊ㐺ษ࡟㟁ሙ࡜☢ሙࡢᙉᗘࢆ

⏕యศᏊࠊ⣽⬊ࠊ⤌⧊ࠊࡑࡋ࡚ಶయ࡟⮳ࡿ⏕࿨ࢩࢫࢸ࣒ࡣ

ㄪᩚࡍࡿࡇ࡜࡟ࡼࡾ⣔ࡢ᭷ຠࣉࣛࣥࢡᐃᩘ㸦㔞Ꮚᛶࡢᙉࡉ

ᖖ࡟እ⏺࡟᫹(ࡉࡽ)ࡉࢀ࡞ࡀࡽࠊ࣑ࢡ࡛ࣟࣞ࣋ࣝࡢ“่⃭”ࡢᣦᶆࡢ୍ࡘ㸧ࢆ⮬⏤࡟ኚ໬ࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࡇ࡜ࠊ୕

ࡀ࣐ࢡࣟࣞ࣋ࣝࡲ࡛ఏ㐩ࡋ㡹೺࡞ᶵ⬟ࢆసࡾฟࡋ࡚࠸ࡿࠋ

ࡘࡵࡣ཯ᛂᗙᶆࡢษࡾ᭰࠼ࡀ㉳ࡇࡿ࡜Ỉ⣲ཎᏊ࠿ࡽゎ㞳ࡋ⏕య⣔ࡢ཯ᛂ⌧㇟ࡢከࡃࡣࠊ」㞧࡞୰࡟≉␗ᛶࠊࡍ࡞ࢃࡕࠊ

࡚࠸ࡃ㟁Ꮚࡢ㣕ᩓ᪉ྥࡀኚ໬ࡍࡿࡢ࡛ࠊࡑࡢ㟁Ꮚࡢ㣕ᩓ᪉㑅ᢥᛶ࣭ᶵ⬟ᛶࢆಖ᭷ࡋ࡚࠸࡚ࠊࡑࡢ≉␗ᛶࡀ⏕࿨⌧㇟ࡢྥࢆ᳨ฟࡍࡿࡇ࡜࡛཯ᛂᗙᶆษࡾ᭰࠼ࢆ᳨ฟ࡛ࡁࡿࡇ࡜ࠊ

㇏࠿ࡉࡢ※Ἠ࡜࡞ࡗ࡚࠸ࡿࠋ⏕యᶵ⬟࡜ࡣࠕእ⏺࠿ࡽࡢ่࡛࠶ࡿࠋᮾ໭኱Ꮫከඖ≀㉁⛉Ꮫ◊✲ᡤࡢ㧗ᶫṇᙪᩍᤵࡢࡶ

⃭࡟ᑐࡍࡿᛂ⟅࡜ࡋ࡚ጞࡲࡿ୍㐃ࡢᵓ㐀ኚ໬࡜ࡑࢀ࡟క࠺࡜࡟ࡑࡢヲ⣽࡞᳨ฟࣉࣟࢺࢥࣝ࡟㛵ࡋ࡚㆟ㄽࢆࡋࡓࠋࣉࣟ

໬Ꮫ཯ᛂ࡛ࠖ࠶ࡾࠊ㝵ᒙࢆ㉺࠼ࡓࠕ≧ែኚ໬ࠖࡢࡘ࡞ࡀࡾ

ࢺࢥࣝ࡜ࡋ࡚ࡣࠊ┿✵୰࡟Ỉ⣲ཎᏊࢆศᏊࣅ࣮࣒࡛┤஺ࡍࡢ⏘≀࡜࠸࠼ࡿࠋࡑࡢࡼ࠺࡞⏕࿨ࢩࢫࢸ࣒ࢆ⌮ゎࡍࡿࡓࡵࡿ㟁ሙ☢ሙ୰࡟ᨺᑕࡋࠊບ㉳ග࡟ࡼࡾ≺ࡗࡓ࢚ࢿࣝࢠ࣮‽ࡢ࢔ࣉ࣮ࣟࢳ࡟ࡣࠊ኱ูࡋ࡚ࠊ⫼ᚋ࡟Ꮡᅾࡍࡿᩘ⌮ᵓ㐀ࢆ఩࡟ୖࡆࡿࠊ᭱ᚋ࡟ࢹ࢕ࢸࢡࢱ࣮ࢆ཯ᛂᗙᶆษࡾ᭰࠼๓࡜

ᥦၐࡍࡿࢺࢵࣉࢲ࢘ࣥⓗᵓᡂㄽⓗᡭἲ࡜ᚤどⓗ࡞❧ሙ࠿ࡽᚋࡢ㟁Ꮚࡢゎ㞳᪉ྥ࡟タ⨨ࡋࠊ㟁Ꮚࡢ㣕ᩓ᪉ྥࢆ᳨ฟࡍࡿ

࣐ࢡࣟ࡞⌧㇟ࡢ෌⌧ࢆヨࡳࡿ࣎ࢺ࣒࢔ࢵࣉⓗ㑏ඖㄽⓗᡭἲ࡜࠸࠺ࡶࡢ࡛࠶ࡿࠋ

ࡀᏑᅾࡍࡿࠋ๓⪅ࡣ኱⫹࡞௬ᐃࡸ⢒ど໬ࡢࡓࡵ࡟⮬↛࡜஋࣭ᙜึ᝿ᐃࡋ࡚࠸ࡓᩘࢸࢫࣛࡢ☢ሙࡢᙉᗘࢆᐇ⌧ࡍࡿࡢࡣ㞳ࡋࡓࣔࢹࣝ࡟㝗ࡿྍ⬟ᛶࡀᏑᅾࡍࡿ୍᪉࡛ࠊᚋ⪅ࡣಶࠎᐇ㦂ⓗ࡟㞴ࡋ࠸࡛࠶ࢁ࠺ࡇ࡜ࡀุ᫂ࡋࠊ࣒࣊ࣝ࣍ࣝࢶࢥ࢖ࡢᚤどⓗ஦㇟ࢆᯛᣲࡍࡿࡔࡅ࡛ࢩࢫࢸ࣒඲యࢆᤊ࠼ࡿࡇ࡜

ࣝ➼࡛ᐇ⌧ྍ⬟࡞ᩘ༑࠿ࡽᩘⓒ࢞࢘ࢫ⛬ᗘࡢ☢ሙᙉᗘୗ࡛

ࡣᅔ㞴࡛࠶ࡿࠋ

཯ᛂᗙᶆษࡾ᭰࠼ࡀ㉳ࡇࡿࡢ࠿ࠊ࠶ࡿ࠸ࡣࠊ㉳ࡇࡗࡓ࡜ࡋ

⮬↛⛉Ꮫ◊✲࡟࠾࠸࡚㠉࿨ⓗ࡞Ⓨᒎࢆࡶࡓࡽࡍࡶࡢࡣࠊ

࡚࡝ࡢ఩⨨࡟࡝ࡢࢧ࢖ࢬࡢࢹ࢕ࢸࢡࢱ࣮ࢆタ⨨ࡍࢀࡤ཯ᛂ

ከࡃࡢሙྜࠊ᪂ࡋ࠸ᐇ㦂ᢏ⾡࡜ࡑࡢ᪂ࡋ࠸ᐇ㦂஦ᐇ࡟ᇶ࡙

ᗙᶆษࡾ᭰࠼ࢆ᳨ฟࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡢ࠿ࡀ᳨ウㄢ㢟࡜ࡋ࠸ࡓ⌮ㄽ࣭ᴫᛕࡢ㌿ᅇ࡛࠶ࡿࠋ㏆ᖺࠊ୍ศᏊィ࡚ᾋୖࡋࡓࠋᢏ⾡➼ࡢ㣕㌍ⓗ࡞㐍ᒎ࡟ࡼࡾࠊࠕほ ࠖࡢᅾࡾ᪉ࡀ኱ࡁ࡞ኚㇺࢆ㐙ࡆࠊ࣭᭷ຠࣉࣛࣥࢡᐃᩘࢆኚ໬ࡉࡏࡿࡇ࡜࡛ࠊ㔞ᏊຊᏛࡢ≉␗ࢧࣈ࣑ࣜ⛊⛬ᗘࡢ᫬㛫ศゎ⬟࡛ࠊ୍ศᏊࣞ࣋ࣝࡢ኱つᶍᵓᴟ㝈࡟࠶ࡓࡿ༙ྂ඾㏆ఝࡀⰋࡃᡂࡾ❧ࡘ㡿ᇦ࠿ࡽࡑࡢᴟ㝈㐀ኚᙧࡸ⣽⬊ࡢศ໬ࡢ⤒᫬ኚ໬ࢆ┤᥋ほ࠿ࡽ㞳ࢀࡓ㡿ᇦࡲ࡛ᐇ㦂ࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋ[ᑎᮏࡽࡍࡿࡇ࡜ࡀྍ⬟PRL 106, 054101 (2011); ᑎᮏࡽPRL 115, 093003(2015)]࡜࡟ࠊ㑄⛣☜⋡ࡀ㢮ఝࡍࡿ᫬㛫㛫㝸Ǽtࡀ㝵ᒙⓗ࡟࡝࠺⏕ࡌ࡛ࡣࠊ㔞Ꮚຠᯝࡣ⪃៖ࡉࢀ࡚࠸࡞࠿ࡗࡓࡀࠊࡇࡢᐇ㦂࡟ࡼࡿ࠿⾲ࡍᅗࢆຠ⋡ⓗ࡟ᚓࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡉࡽ࡟ࠊྛ᫬㛫ࡾࠊ཯ᛂᗙᶆษࡾ᭰࠼ᶵᵓ࡟࡜ࡗ࡚㔞Ꮚຠᯝࡀ࡝ࡢࡼ࠺࡞

㝵ᒙ࡛ࡢ⢒ど໬ࡉࢀࡓࢿࢵࢺ࣮࣡ࢡࡢ㏿ᗘᐃᩘࡀ䂴㼠୙ኚᙺ๭ࢆᯝࡓࡍࡢ࠿ࢆ᳨ドࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡿࠋ࡛࠶ࡿ࠿ࢆホ౯ࡍࡿࡇ࡜࡛ࠊ཯ᛂࢿࢵࢺ࣮࣡ࢡ࡜ࡋ࡚ࡢ⢒1䠅H. Teramoto, M. Toda, M. Takahashi, H. Kono and T. Komatsu-

ど໬ྍ⬟ᛶࢆホ౯࡛ࡁࡿࠋ

zaki : “Mechanism and Experimental Observability of Global Switch-

1) Y. Nagahata, S. Maeda, H. Teramoto, T. Horiyama, T. Taketsugu

ing Between Reactive and Nonreactive Coordinates at High Total En-

and T. Komatsuzaki : “Deciphering Time Scale Hierarchy in Reaction

ergies”, Physical Review Letter, 115(093003) (2015)

Networks ”, The Journal of Physical Chemistry B(2015)2䠅H. Teramoto, M. Toda and T. Komatsuzaki : “Breakdown mechanisms of normally hyperbolic invariant manifolds in terms of unstable
periodic orbits and homoclinic/heteroclinic orbits in Hamiltonian systems”, Nonlinearity, 28(2677) (2015)㸦2㸧ᵓ㐀␗ᛶ໬཯ᛂࢿࢵࢺ࣮࣡ࢡ࠿ࡽ᫬㛫㝵ᒙᵓ㐀ࢆ᙮ࡾࡔࡍ᝟ሗ⛉Ꮫⓗ࢔ࣝࢦࣜࢬ࣒ࡢ㛤Ⓨ໬Ꮫ཯ᛂࡣࠊࣇ࢙࣒ࢺ⛊࠿ࡽᩘ᫬㛫࡟Ώࡿከᵝ࡞᫬㛫ࢫࢣ࣮࡛ࣝほࡉࢀࡿࠋࡑࡢ཯ᛂ㏿ᗘᐃᩘࢆぢ✚ࡶࡿ᭱ࡶᶆ

‽ⓗ࡞⌮ㄽ࡛࠶ࡿ㑄⛣≧ែ⌮ㄽࡣ⣲཯ᛂ࡟࠾࠸࡚ᡂຌࡋࡓ
⌮ㄽ࡛࠶ࡿࠋࡑࡢࡓࡵࠊ
㸦ከᵝ࡞᫬㛫ࢫࢣ࣮ࣝ࡜཯ᛂ⤒㊰ࢆࡶࡘ㸧཯ᛂࢿࢵࢺ࣮࣡ࢡࡢྛ⣲཯ᛂࡢぢ✚ࡶࡾ࡟ᑐࡋ࡚ぢᅗ 1 ྲྀࡾฟࡋ࡚ࡁࡓ཯ᛂ᫬㛫㝵ᒙ࡜ศᏊᵓ㐀ࡢ㛵ಀ✚ࡶࡾࡢⰋࡉࡀᮇᚅ࡛ࡁࡿࠋ௚᪉࡛ࠊᐇ㦂⣔࡟ࡣᅛ᭷ࡢ᫬
✵㛫ゎീᗘࡀ࠶ࡿࡓࡵࠊࡺࡗࡃࡾ࡜㐍⾜ࡍࡿ኱ࡁ࡞཯ᛂ࡟

㸦3㸧ࢺ࣏ࣟࢪ࢝ࣝ⤯⦕యࡢ⾲㠃≧ែࡢไᚚ⌮ㄽ╔┠ࡍࡿ࡜ࠊヲ⣽࡞཯ᛂࡀ⢒ど໬ࡉࢀ࡚ぢ࠼࡞ࡃ࡞ࡗ࡚ࡋ

ࢺ࣏ࣟࢪ࢝ࣝ⤯⦕య࡜ࡣࣂࣝࢡ࡛ࡣ⤯⦕య࡛࠶ࡿࡀ⾲㠃ࡲ࠺ࠋᮏᖺᗘࠊࡇࡢ⢒ど໬࡜ほ ᫬㛫ࢫࢣ࣮ࣝࡢ㛵ಀࢆ࡛᫂ࡣఏᑟᛶࢆ♧ࡍ࡜࠸࠺ࠊ୍ぢࠊ⤯⦕యࡀ⾲㠃ࡔࡅ࣓ࢵ࢟

ࡽ࠿࡟ࡍࡿྍど໬ἲࢆ㛤Ⓨࡋࡓࠋࡉࢀࡓࡼ࠺࡞≀ᛶࢆ♧ࡍࠋࣂࣥࢻ⌮ㄽ࡟ࡼࡿ࡜ࠊ≀㉁ࡢ౯

ࡇࡢᩘᖺࡢ㛫࡟ࠊ➨୍ཎ⌮ィ⟬࡟ᇶ࡙ࡃ཯ᛂ⤒㊰⮬ື᥈㟁Ꮚᖏ࡜ఏᑟᖏࡢ㛫࡟⇕ບ㉳࢚ࢿࣝࢠ࣮ࡼࡾࡶ኱ࡁ࡞ࢠࣕ

⣴࢔ࣝࢦࣜࢬ࣒ࡸMDࢩ࣑࣮ࣗࣞࢩࣙࣥ࠿ࡽᵓ⠏ࡍࡿ࣐ࣝࢵࣉࡀ㛤࠸࡚࠸ࡿ࡜⤯⦕య࡜࡞ࡿࡢ࡛ࠊࢺ࣏ࣟࢪ࢝ࣝ⤯⦕ࢥࣇ≧ែࣔࢹࣝࠊ୍ศᏊィ࠿ࡽᚓࡽࢀࡓ᫬⣔ิࡢ㞃ࢀ࣐యࡣࣂࣝࢡ࡛ࡣࣂࣥࢻࢠࣕࢵࣉࡀ࠶ࡾࠊ⾲㠃࡛ࡣ㛢ࡌ࡚࠸ࣝࢥࣇࣔࢹࣝࢆ⏝࠸ࡓゎᯒ㸦䃔ᶵᲔ㸧࡟ࡼࡗ࡚ࠊィ⟬࣭ᐇࡿࠋࡑࡢࡼ࠺࡞ࢠࣕࢵࣉࡀ㛢ࡌ࡚࠸ࡿⅬࡣࠊࢹ࢕ࣛࢵࢡ᪉

㦂୧㠃࡛཯ᛂࢿࢵࢺ࣮࣡ࢡࢆ┤᥋ᢳฟࡍࡿ᪉ἲࡀ㛤Ⓨࡉࢀ⛬ᘧࡢ㉁㔞ࡀࢮࣟࡢ⮬⏤⢏Ꮚ࡜ྠࡌ࢚ࢿࣝࢠ࣮࡜㐠ື㔞ࡢࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊᚓࡽࢀࡓࢿࢵࢺ࣮࣡ࢡࡢࣀ࣮ࢻᩘࡣᩘ

ศᩓ㛵ಀࢆ♧ࡍࡢ࡛ࠊࢹ࢕ࣛࢵࢡⅬ࡜࿧ࡤࢀ࡚࠾ࡾࠊ㉁㔞

༑࠿ࡽᩘⓒ୓࠶ࡾࠊࡑࢀࡽࢆゎ㔘ࡍࡿୖ࡛ၥ㢟ࡀ࠶ࡗࡓࠋ

ࢮࣟࡢ⢏Ꮚࡢࡼ࠺࡟᣺ࡿ⯙࠺ࡓࡵ࡟ࠊ┬࢚ࢿࣝࢠ࣮ࢺࣛࣥ

ࡇࡢࡼ࠺࡞ㄢ㢟ࢆゎỴࡍࡿࡓࡵࠊỌᖭࡽࡣࠊ໭ᾏ㐨኱Ꮫࢪࢫࢱ࣮➼࡬ࡢᛂ⏝ࡀᮇᚅࡉࢀ࡚࠸ࡿࠋࡲࡓࠊࡑࡢ㏆ഐ࡛ࡢ๓⏣⌮Ặࠊᇸ⋢኱Ꮫࡢᇼᒣ㈗ྐẶ࡜༠ാ࡛ࠊ
͆ ᮶͇᭱ᑠ

ࡣࠊ㟁Ꮚࡢ㐠ື㔞࡜㟁Ꮚࡢࢫࣆࣥࡢ᪉ྥࡀࣟࢵࢡࡉࢀ࡚࠾

࡜࡞ࡿࢿࢵࢺ࣮࣡ࢡୖࡢ㑄⛣≧ែࢆᑟධࡋࠊࡑࢀ࡟ᇶ࡙࠸

ࡾࠊୖྥࡁࡢࢫࣆࣥࢆࡶࡘ㟁Ꮚࡣྑഃ࡟ࠊୗྥࡁࡢࢫࣆࣥ

࡚ࢿࢵࢺ࣮࣡ࢡ࠿ࡽ཯ᛂ᫬㛫㝵ᒙࡢᢳฟἲࢆ⊂⮬࡟㛤Ⓨࡋࢆࡶࡘ㟁Ꮚࡣᕥྥࡁ࡟ືࡃࠊ࡜࠸࠺ࡼ࠺࡟࡞ࡗ࡚࠸ࡿࠋࡑ

ࡓࠋ㛤Ⓨࡋࡓ࢔ࣜࣝࣅࢽ࢚࣮ࣝࢸࣝࡢࢡࣛ࢖ࢮࣥ㌿఩ࡢ㝿ࢀࢆ⏝࠸ࡿ࡜≉ᐃࡢࢫࣆࣥࡢ᪉ྥࢆᣢࡗࡓ㟁ὶࢆྲྀࡾฟࡍ

ࡢ␗ᛶ໬཯ᛂࢿࢵࢺ࣮࣡ࢡࡢゎᯒ࡟ྲྀࡾ⤌ࢇࡔࠋࡇࡢゎᯒࡇ࡜ࡀ࡛ࡁࠊࢫࣆࣥࢺࣟࢽࢡࢫ࡬ࡢᛂ⏝ࡶྍ⬟࡛࠶ࡿࠋࡇ

࡟ࡼࡾࠊᚊ㏿ẁ㝵ࡢ㏿ᗘᐃᩘࡸ㎿㏿ᖹ⾮㏆ఝ࡛ࡣ⾲⌧࡛ࡁࡢࢺ࣏ࣟࢪ࢝ࣝ⤯⦕యࠊ≉࡟ࡑࡢ࢝ࢠ࡜࡞ࡿࢹ࢕ࣛࢵࢡⅬ࡞࠿ࡗࡓࠊ཯ᛂ⣔࡛ࡢ࢚ࣥࢺࣟࣆ࣮࡟ࡼࡿᏳᐃ໬ࢆṇ☜࡟㏆ഐࡢࣁ࣑ࣝࢺࢽ࢔ࣥࡢ୍⯡ⓗ⾲ᘧࢆᗈ୰ศゎࢆ⏝࠸࡚ᚓ⾲⌧ࡍࡿࡇ࡜࡟ᡂຌࡋࠊᚓࡓ཯ᛂ᫬㛫㝵ᒙࡀほ᫬㛫㛫㝸ࡓࠋࡲࡓࠊࡑࡢ୍⯡ⓗ࡞⾲ᘧࡢୗࠊࢹ࢕ࣛࢵࢡⅬ㏆ഐࡢࣂࢆኚ࠼ࡓሙྜ࡟⏕ࡌࡿ㝵ᒙ㛵ಀ࡜ᑐᛂࡍࡿࡇ࡜ࢆ♧ࡋࡓࠋࣥࢻࡢᵓ㐀ࡀ࡝ࡢࡼ࠺࡟࡞ࡿࡢ࠿ࠊࡑࢀࢆᛂ⏝≉␗Ⅼㄽࡢຍ࠼࡚ࠊᚓࡽࢀࡓ᫬㛫㝵ᒙ࡟ࡣࠊᏳᐃ࡞㒊ศᵓ㐀ࡀ࠶ࡿࡇ

ほⅬ࠿ࡽศ㢮ࡍࡿ࡜࡝ࡢࡼ࠺࡞ࣂࣥࢻ஺ᕪࡀྍ⬟࡛࠶ࡿࡢ࡜ࢆ᫂ࡽ࠿࡟ࡋࠊࡑࢀࡀn-䃟ඹᙺ࡟ࡼࡿᏳᐃ໬࡛࠶ࡿࡇ࡜

࠿ࠊࡑࡢࢹ࢕ࣛࢵࢡⅬࢆ≀㉁࡟እሙ➼ࢆຍ࠼ࡿࡇ࡜࡛࡝ࡢ

ࢆᣦ᦬ࡋࡓࠋ

ࡼ࠺࡟ไᚚ࡛ࡁࡿࡢ࠿ࠊ࡜࠸࠺ࡇ࡜ࢆゎ᫂ࡍࡿࡓࡵࡢᩘᏛ

ࡋ࠿ࡋࠊࡇࡢࢿࢵࢺ࣮࣡ࢡୖࡢ㑄⛣≧ែࢆ⏝࠸ࡓゎᯒࡣࠊⓗ⌮ㄽࢆᛂ⏝≉␗Ⅼㄽࡢᑓ㛛ᐙ࡛࠶ࡿ໭ᾏ㐨኱Ꮫ⌮Ꮫ㒊ᩘィ⟬」㞧ᛶ࡜௬ᐃࡢṇᙜᛶࡢ୧㠃࡛ၥ㢟ࡀ࠶ࡗࡓࠋỌᖭࡽᏛ⛉ࡢἨᒇ࿘୍ᩍᤵࠊࢫࣆࣥࢺࣟࢽࢡࢫࡢᑓ㛛ᐙ࡛࠶ࡿ໭ࡣほ᫬㛫㛫㝸ࢆኚ࠼ࡿࡇ࡜࡟ࡼࡾ⏕ࡌࡿ࣐ࣝࢥࣇᛶࡢΰ

ᾏ㐨኱Ꮫ㟁Ꮚ⛉Ꮫ◊✲ᡤࡢ㏆⸨᠇἞෸ᩍᤵࡽ࡜ᵓ⠏ࡋࡓࠋྜ㝵ᒙࢆຠ⋡ⓗ࡟┤᥋ྲྀࡾฟࡍ࢔ࣝࢦࣜࢬ࣒ࢆ⪃᱌ࡋࡓࠋணഛⓗ࡞⤖ᯝ࡛࠶ࡿࡀࠊࡇࡢ⌮ㄽࢆ⏝࠸ࡿࡇ࡜࡛ࠊࡇࢀࡲ

ᥦ᱌ἲࢆ⏝࠸ࢀࡤࠊึᮇศᕸ࡟౫Ꮡࡏࡎࠊ୚࠼ࡓᇶ‽ࢆࡶ࡛▱ࡽࢀ࡚࠸ࡓᦤືࡢ⤖ᯝ㸦L. Fu, Phys. Rev. Lett. 103,

266801 (2009)㸧ࢆ⤌⧊ⓗ࡟㧗ḟࡲ࡛᥎ࡋ㐍ࡵࠊࡇࢀࡲ࡛ᚓ

ࢻࡢᗄఱᏛⓗᵓ㐀ࡀኚࢃࢁ࠺࡜ࡍࡿศᒱ࡟࠾࠸࡚⌧ࢀࡿࠋࡽࢀ࡚࠸ࡓࢹ࢕ࣛࢵࢡⅬ㏆ഐ࡛ࡢ㟁Ꮚࢫࣆࣥࡢᮇᚅ್ࢆ㸰ࡑࡢࡼ࠺࡞஺ᕪࢆᣢࡘࣁ࣑ࣝࢺࢽ࢔ࣥࡢᬑ㐢㛤ᢡࢆㄪ࡭ࡿ

๭⛬ᗘࡶᨵၿ࡛ࡁࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋࡇ࡜࡟ࡼࡾࠊࡑࡢศᒱⅬ࡟࠾࠸࡚ࣁ࣑ࣝࢺࢽ࢔ࣥࢆᦤືࡍ

1) H. Teramoto, K. Kondo, S. Izumiya, M. Toda and T. Komatsuzaki:ࡿ࡜⾪✺ࡋࡓࣂࣥࢻ࡟࡝ࡢࡼ࠺࡞ᗄఱᏛⓗኚ໬ࡀ⏕ࡌࡿࡢ

“Classification of Hamiltonians in neighborhoods of band crossings࠿ࢆㄪ࡭ࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

in terms of the theory of singularities”, Journal of Mathematical Physics, 58: 073502-1–073502-39 (2017)࡞࠾ࠊ㸦3㸧
㸦4㸧ࡢ◊✲ࡣ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ࣭ᡓ␎ⓗ๰㐀◊✲᥎㐍஦ᴗ/ࡉࡁࡀࡅࠕ♫఍ⓗㄢ㢟ࡢゎỴ࡟ྥࡅࡓᩘᏛ࡜
ㅖศ㔝ࡢ༠ാࠖ㸪ࠕ≉␗Ⅼㄽࡢ≀㉁⛉Ꮫ࡬ࡢᛂ⏝ࠖ㸦H28-31,ᑎᮏ ኸ෸ᩍᤵ௦⾲㸧ࡢᡂᯝ࡛࠶ࡿࠋ

ᅗ 2㸸(1) ᛂ⏝≉␗Ⅼㄽ࡛ᚓࡽࢀࡿ౯㟁Ꮚᖏࡢࣂࣥࢻ࡜ఏᑟᖏ
ࡢࣂࣥࢻࡢ஺ᕪࡢᵝᏊࠋࡇࡢࣂࣥࢻ㏆ഐ࡛ࣁ࣑ࣝࢺࢽ࢔ࣥࡢ୍
⯡ⓗ࡞᣺ࡿ⯙࠸ࢆグ㏙ࡍࡿࡓࡵ࡟ࡣࠊD0, D1 ࠾ࡼࡧD2 ࡢ୕ࡘࡢࣃ࣓࣮ࣛࢱࡔࡅ࡛༑ศ࡛࠶ࡿࡇ࡜ࡀᬑ㐢㛤ᢡࡢ⌮ㄽࡼࡾศ࠿
ࡾࠊࡑࡢ୕ࡘࡢࣃ࣓࣮ࣛࢱࢆ(b)࡛♧ࡍࡼ࠺࡟࠸ࢁ࠸ࢁ࡜ኚ໬ࡉ
ࡏࡿ㸦እሙ➼ࢆ௓ࡋ࡚㸧ࡇ࡜࡛ࠊ(1)ࡢࣂࣥࢻ஺ᕪ㛫஺ᕪࢆ(2)((2’)ࡣࡑࡢᣑ኱ᅗ)࠾ࡼࡧ(3)ࡢࡼ࠺࡟ᵝࠎ࡞ᙧ࡟ศᒱࡉ
ࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

ᅗ3㸸ࣂࣥࢻ஺ᕪࡀ࠸ࡃࡘ࠿ࡢ࣡࢖ࣝⅬ࡟ศᒱࡍࡿᵝᏊ㸦5㸧᝟ሗ⇕ຊᏛࡢᵓ⠏࣐࢖ࢡࣟ࠿ࡽࢼࣀࢫࢣ࣮ࣝࡢ࣓ࢰࢫࢥࣆࢵࢡ㡿ᇦ࡟࠾࠸࡚, ࢲ࢖ࢼ࣑ࢡࢫࡢ☜⋡ᛶࢆඖ࡟⇕ຊᏛࢆᵓᡂࡋࡼ࠺࡜ࡍ

㸦4㸧ࣂࣥࢻ஺ᕪ㏆ഐࡢࣁ࣑ࣝࢺࢽ࢔ࣥࡢᚤศ఩┦ᗄఱᏛⓗศ㢮ࠊࣂࣥࢻ࢚ࣥࢪࢽ࢔ࣜࣥࢢ࡟ྥࡅ࡚
ࣂࣥࢻ࢚ࣥࢪࢽ࢔ࣜࣥࢢ࡜ࡣᅛయࡢ」ᩘࡢࣂࣥࢻࢆ⾪✺ࡉࡏࡿࡇ࡜࡟ࡼࡾࠊࡑࡢࣂࣥࢻᵓ㐀ࢆኚ໬ࡉࡏࠊࡑࢀ࡟ࡼ
ࡾ≀ᛶࡢไᚚࢆ┠ᣦࡍࡶࡢ࡛࠶ࡾࠊDirac-cone engineeringࢆྵࡴࡼࡾ୍⯡ⓗ࡞ᯟ⤌ࡳࢆᣦࡍࠋ㏆ᖺࠊࢼࣀࢸࢡࣀࣟ
ࢪ࣮࠾ࡼࡧほᢏ⾡ࡢ㐍Ṍ࡟ࡼࡾࠊࣂࣥࢻᵓ㐀ࢆ≀ᛶࣃ࣓࣮ࣛࢱࢆኚ໬ࡉࡏࡿࡇ࡜࡛ไᚚࡋࡓࡾࠊࣂࣥࢻᵓ㐀ࢆ┤᥋ほࡋࡓࡾࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡗ࡚ࡁࡓࠋࡑࡢࣂࣥࢻ࢚ࣥ

ࢪࢽ࢔ࣜࣥࢢࢆᐇ⌧ࡍࡿࡓࡵ࡟ࡣࠊ୚࠼ࡽࢀࡓ⤖ᬗࡢᑐ⛠ᛶ࠾ࡼࡧ᫬㛫཯㌿ᑐ⛠ᛶࡢୗࠊ஧ࡘࡢࣂࣥࢻࢆ⾪✺ࡉࡏࡿࡇ࡜࡛ࣂࣥࢻ࡟࡝ࡢࡼ࠺࡞ᗄఱᏛⓗኚ໬ࡀ⏕ࡌࠊࡑࢀ࡟ࡼ
ࡾ࡝ࡢࡼ࠺࡟≀ᛶࡀኚࢃࡿࡢ࠿ࢆ⌮ゎࡍࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋᮏ◊✲࡛ࡣࡲࡎ᫬㛫཯㌿ᑐ⛠ᛶཪࡣ✵㛫཯㌿ᑐ⛠ᛶࡀ◚ࢀࡓ≧ἣ࡛ࠊ஧ࡘࡢࣂࣥࢻࡀ⾪✺ࡍࡿ▐㛫࡟ࣂࣥࢻ࡟࡝
ࡢࡼ࠺࡞ᗄఱᏛⓗ࡞ኚ໬ࡀ⏕ࡌ࠺ࡿࡢ࠿ࡢໟᣓⓗ࡞ࣜࢫࢺࢆసᡂࡋࡓ[JMP 58, 073502 (2017)]ࠋ௨ୖࡢࡼ࠺࡞᫬㛫཯㌿ᑐ⛠ᛶཪࡣ✵㛫཯㌿ᑐ⛠ᛶࡀ◚ࢀࡓሙྜ࡟ࡣࠊࢡ࣐ࣛ
࣮ࢫ⦰㔜ࡀゎࡅ࣡࢖ࣝⅬ࡜࿧ࡤࢀࡿࣂࣥࢻ஺ᕪࡀ⏕ࡌ࠺ࡿࠋ
࣡࢖ࣝⅬࡣ㏆ᖺ஧ࡘࡢᐇ㦂ࢢ࣮ࣝࣉ࡟ࡼࡾ┦ḟ࠸࡛ࡑࡢᏑ
ᅾࡀᐇ㦂ⓗ࡟ࡶド᫂ࡉࢀ࡚࠸ࡿࠋᮏ◊✲࡛ࡣࡑࡢࡼ࠺࡞࣡
࢖ࣝⅬࢆྵࡴࡼࡾ୍⯡ࡢࣂࣥࢻ஺ᕪࡢໟᣓⓗ࡞ࣜࢫࢺࢆᚓ
ࡓࠋࡑࢀࡽࡣ஧ࡘࡢࣂࣥࢻࡀ⾪✺ࡋࠊࡲࡉ࡟ࣂࣥ

ࡿ☜⋡ⓗ࡞⇕ຊᏛ࡜࿧ࡤࢀࡿศ㔝ࡀ࠶ࡿࠋ☜⋡ⓗ࡞⇕ຊᏛ࡟࠾࠸࡚, ≉࡟㏆ᖺ࡛ࡣᚑ᮶ࡢ᝟ሗ⌮ㄽ࡜⇕ຊᏛࡢ㛵ಀࡀ㆟ㄽࡉࢀ࡚࠾ࡾ, ᝟ሗ⌮ㄽ࡜⇕ຊᏛࡢ⼥ྜศ㔝࡛࠶ࡿ᝟ሗ
⇕ຊᏛ࡜࿧ࡤࢀࡿ◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿࠋࡇࡢ᝟ሗ⇕ຊᏛࡣ࣓ࢰࢫࢥࣆࢵࢡ࡞⏕య⌧㇟࡛࠶ࡿ⣽⬊ෆࡢ⏕໬Ꮫ཯ᛂࡢ᝟
ሗఏ㐩࡞࡝࡟㐺⏝ྍ⬟࡞ࡓࡵ, ᝟ሗ⇕ຊᏛࢆ⏝࠸ࡿࡇ࡜࡛
⏕య⣔ࡢ᝟ሗฎ⌮ࢆ⇕ຊᏛࢆ࣮࣋ࢫ࡟㆟ㄽࡍࡿࡇ࡜ࡀ࡛ࡁ
ࡿࠋ┤㏆࡛ࡣ☜⋡ⓗ࡞⇕ຊᏛࢆ࣮࣋ࢫ࡜ࡋ࡚, ᝟ሗ⌮ㄽࡢᗄఱᏛⓗ࡞⌮ㄽᙧᘧ࡛࠶ࡿ᝟ሗᗄఱ࡜ࡢ㛵ಀࡢゎ᫂ࢆ⾜࡞ࡗࡓࠋ᝟ሗᗄఱ࡟࠾ࡅࡿᗄఱᏛ㔞ࡣ, ⇕ຊᏛⓗ࡞࢚ࣥࢺࣟࣆ
࣮ኚ໬ࢆ⏝࠸࡚グ㏙࡛ࡁࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋ, ᗄఱᏛⓗ࡞୙➼ᘧ࠿ࡽ⇕ຊᏛⓗ࡞୙☜ᐃᛶཎ⌮ࢆᑟࡃࡇ࡜࡟ᡂຌࡋࡓࠋ
ࡇࢀࡣ, ≧ែࡢ㑄⛣࡟㛵ࡍࡿ⇕ࢥࢫࢺ࡜, 㑄⛣ࢫࣆ࣮ࢻࡢ
㛫ࡢࢺ࣮ࣞࢻ࢜ࣇ㛵ಀ࡟࡞ࡗ࡚࠾ࡾ, 㓝⣲཯ᛂ⣔࡞࡝ࡢ⏕໬Ꮫ཯ᛂ࡟ࡼࡗ࡚⾜ࢃࢀࡿ᝟ሗఏ㐩ࡢ⇕ຊᏛⓗ࡞ཎ⌮ⓗ㝈⏺ࢆ୚࠼ࡿࡶࡢ࡟࡞ࡗ࡚࠸ࡿࠋ
(6) ᅇ㌿࣮ࣔࢱ࣮F 1 ̺ATPaseࡢ୍ศᏊ᫬⣔ิࢹ࣮ࢱ࠿ࡽ
ᵓᡂࡍࡿ཯ᛂᶵᵓࡢゎ᫂⏕య⣔ෆࡢ࣓࢝ࢽࢬ࣒ࢆ⌮ゎࡍࡿୖ࡛᭱ࡶ㔜せ࡞㘽ࡢ୍ࡘ࡜ࡋ࡚ࠊ㓝⣲ࡀ࡝ࡢࡼ࠺࡟㸦໬Ꮫ㸫ຊᏛ࢚ࢿࣝࢠ࣮ኚ᥮
ࡢ㧗ຠ⋡࡜࠸ࡗࡓ㸧཯ᛂಁ㐍ᛶࡸᇶ㉁≉␗ᛶࢆ⋓ᚓࡋ࡚࠸ࡿࡢ࠿ࡀὀ┠ࡉࢀ࡚࠸ࡿࠋᅇ㌿ศᏊ࣮ࣔࢱ࣮࡛࠶ࡿ࢔ࢹࣀ

ࡵ࡟ࠊ᫬⣔ิࡢࢺࣞࣥࢻࢆ᳨ฟࡍࡿኚ໬Ⅼゎᯒࡸࢧࣥࣉࣜ
ࣥࢢㄗᕪࢆ⪃៖ࡋࡓࢯࣇࢺࢡࣛࢫࢱࣜࣥࢢἲ㸦ᅗ 4c㸧ࢆ㛤Ⓨࡋ࡚ࡁࡓࠋࡇࢀࡽࡢᡭἲ࡟ࡼࡗ࡚F 1 ࡢゐ፹≧ែࢆグ㏙ࡍࡿᵝࠎ࡞⤫ィ㔞ࢆᵓᡂࡍࡿࡇ࡜ࡀ࡛ࡁࠊゐ፹ࢧ࢖ࢡࣝࡢ␗
࡞ࡿᡂศࡢືຊᏛ㸦ࡓ࡜࠼ࡤࠊATP⤖ྜࠊADPᨺฟࠊATPຍỈศゎࠊࣜࣥ㓟ᨺฟ㸧ࢆ≉ᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋᮏ◊✲࡛ࡣࠊຍỈศゎ࡜ࣜࣥ㓟ᨺฟࡀ㉳ࡇࡿ᫬ࡢᅇ㌿ఇṆ㐣⛬࡟╔┠ࡋࡓࠋᅇ㌿ఇṆ㐣⛬୰ࡢືຊᏛࢫ࣮࣒࢟ࢆ≉ᐃࡋࡓ⤖ᯝࡣ㸦ᅗ4e㸧ࠊ⤖ྜࡋࡓATPࡀຍỈศゎ๓ᚋ࡛⣙ 20r࡜࠸࠺ഹ࠿࡞ゅᗘቑศ(d 2 +d 1 )ࢆㄏⓎࡋࠊࡑࡢḟ࡟௚ࡢゐ፹㒊఩࡛ࡢࣜࣥ㓟ᨺฟ㸦ᅗ 4d㸧ࡀ㉳ࡇࡿ࡜࠸࠺᪂ࡓ࡞࣓࢝ࢽࢬ࣒ࢆ♧၀ࡋ࡚࠸ࡿࠋ໬Ꮫ̺ຊᏛ࢝ࢵࣉࣜࣥࢢࡢຠᯝࡣࠊ㟁Ꮚ⛣ື㏿ᗘㄽ
ࡢSumi-Marcusࣔࢹࣝ(Sumi et al., J. Chem. Phys., 84,4894, 1986)࡟㢮ఝࡢ 2 ḟඖ཯ᛂᣑᩓࣔࢹࣝ㸦ᅗ 4d㸧࡛ㄝ᫂ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡇࡢᯟ⤌ࡳ࡟ࡼࡗ࡚ࠊATP⤖ྜ࡜ࣜࣥ㓟ᨺฟ཯ᛂࡢ⮬⏤࢚ࢿࣝࢠ࣮ࡼࡾࡶⴭࡋࡃᑠࡉ࠸⮬⏤࢚ࢿࣝࢠ࣮ࢆᣢࡘ⤖ྜATPࡢຍỈศゎ཯ᛂ࡟ࡣ㸰ࡘࡢ㔜せ࡞ᙺ๭ࡀ࠶ࡿࡇ࡜ࢆᣦ᦬࡛ࡁࡿࠋ㸯ࡘ┠ࡣࠊࣜࣥ㓟ࡢᨺฟࢆຍ
㏿ࡉࡏࡿࡁࡗ࠿ࡅࢆసࡿാࡁ࡜ࠊ㸰ࡘ┠ࡣゐ፹ࢧ࢖ࢡࣝࡢ
ṇࡋ࠸཯ᛂ㡰ᗎࢆಁࡍാࡁ࡛࠶ࡿࠋ
୍᪉ࠊࡇࡢ 2 ḟඖ཯ᛂᣑᩓࣔࢹࣝࡢ㔜せ࡞≉ᚩࡣゐ፹཯ᛂ㏿ᗘᐃᩘࡀJ-ࢧࣈࣘࢽࢵࢺࡢゅᗘ࡟౫Ꮡࡍࡿࡇ࡜࡛࠶ࡿࠋ
⤖ᯝ࡜ࡋ࡚ࠊほࡉࢀࡓゐ፹཯ᛂ㏿ᗘᐃᩘࡣȚ-ࢧࣈࣘࢽࢵ

ࢺゅᗘࡢ⇕ࡺࡽࡂࡢ⦆࿴᫬㛫ࢫࢣ࣮ࣝ࡟ࡼࡗ࡚ㄪ⠇ࡉࢀ࠺ࡿྍ⬟ᛶࡀ࠶ࡾࠊࡇࡢ㦫ࡃ࡭ࡁ≉ᚩࡣࢼࣀࢫࢣ࣮࡛ࣝືస
ᅗ 4㸸(a) FoF1̺ATPྜᡂ㓝⣲࡜(b) ATPࢆຍỈศゎࡍࡿỈ⁐ᛶᡂศࡢ
F1-ATPase(Yoshida et al., Nat. Rev., 2, 669, 2001)ࠋ(c) ୗᅗ㸸ࢺࣞࣥࢻ࡟࠾ࡅࡿኚ໬ࢆ᳨ฟࡍࡿࡓࡵ࡟J-ࢧࣈࣘࢽࢵࢺࡢ༢୍࣮ࣔࢱᅇ㌿ࢺࣛࢪ࢙ࢡࢺࣜࢆᛂ⏝ࡋࡓኚ໬Ⅼゎᯒࠋ◚⥺㸸᳨ฟࡉࢀࡓኚ
໬Ⅼࠊ⅊Ⰽ㒊ศ㸸ኚ໬Ⅼࡢ఩⨨ࡢㄗᕪ⠊ᅖࠊᤄධ⏬ീ㸸XYᖹ㠃ୖࡢᅇ㌿㊧ࠋୖᅗ㸸ࠕఇṆࠖ࡜ࠕᅇ㌿ࠖࢆ≉ᐃࡍࡿኚ໬Ⅼࡢ㛫㝸ࡢࢯࣇࢺࢡࣛࢫࢱࣜࣥࢢࠋࢡࣛࢫࢱࡀ 95㸣௨ୖࡢ☜⋡࡛ఇṆ≧ែ࡟ᒓࡍࡿሙ
ྜ࡟ࠊኚ໬Ⅼࡢ㛫㝸ࢆࠕఇṆࠖ࡟๭ࡾᙜ࡚ࡓࠋ(d) ᫬⣔ิศᯒ࡟ࡼ
ࡗ࡚♧ࡉࢀࡓゐ፹཯ᛂ᫬ࡢᅇ㌿ఇṆ࡟࠾ࡅࡿ໬Ꮫ̺ຊᏛ࢝ࢵࣉࣜࣥ
ࢢࢆᥥ෗ࡍࡿ 2 ḟඖ⮬⏤࢚ࢿࣝࢠ࣮ࣉࣟࣇ࢓࢖ࣝࠋqhyd࡜qPiࡣຍỈศゎ࡜ࣜࣥ㓟ᨺฟࡢ཯ᛂᗙᶆ࡛ࠊTࡣJ-ࢧࣈࣘࢽࢵࢺゅᗘ࡛࠶ࡿࠋୗ
ᅗ㸸๓ຍỈศゎ཯ᛂࠋୖᅗ㸸ࣜࣥ㓟ᨺฟ཯ᛂࠋ2 ḟඖ཯ᛂᅗࡢ㔜せ࡞≉ᚩ࡟ࡣࠊゅᗘ౫Ꮡࡢ཯ᛂ㏿ᗘᐃᩘkhyd(T)࡜kPi(T)ࡀ࠶ࡿࠋⓑ⥺ࡣ⮬⏤࢚ࢿࣝࢠ࣮⾲㠃ୖࡢ཯ᛂ㸦⦪⥺㸧࡜ᣑᩓ㸦ᶓ⥺㸧⤒㊰ࢆ♧ࡋ࡚࠸ࡿࠋ(e) ゐ፹཯ᛂ᫬ࡢᅇ㌿ఇṆ࡟ᑐᛂࡍࡿศᏊ࣮ࣔࢱ࣮ࡢࢾࢡࣞ
࢜ࢳࢻ≧ែࠋ

ࡍࡿศᏊᶵᲔ࡛ࡋ࠿㉳ࡇࡾ࠼࡞࠸ࡶࡢ࡜ᮇᚅࡉࢀࡿࠋ

㸦ᅗ 4a㸧ࡶࡑࢩࣥ୕ࣜࣥ㓟ྜᡂ㓝⣲㸦F o F 1 ̺ATPྜᡂ㓝⣲㸧ࡢᅇ㌿ゅᗘ࡟ไᚚࡉࢀ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾ㸪≉࡟ゅ

ࡢ 1 ࡘ࡛ࠊࡑࡢᅇ㌿ࢆ฼⏝ࡋࠊከࡃࡢ⏕యศᏊᶵᲔࢆ㥑ືᗘ౫Ꮡᛶࡢᙉ࠸ࣜࣥ㓟ゎ㞳㐣⛬࡛ࡣ䃒ࡀ⁐፹࠿ࡽཷࡅࡿ⇕ࡍࡿࡓࡵ࡟ຠ⋡ⓗ࡟ATPྜᡂࢆゐ፹ࡋ࡚࠸ࡿࠋF 1 ̺ATPaseᦂࡽࡂࢆ࠺ࡲࡃ཯ᛂ࡟฼⏝ࡋ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡗ࡚࠸ࡿࠋ

1) C. Li, H. Ueno, R. Watanabe, H. Noji and T. Komatsuzaki : “ATPhydrolysis assists phosphate release and promotes reaction orderingin F1-ATPase”, Nature Communications, 6(10223) : 1-9 (2015)

㸦7㸧F1 ศᏊ࣮ࣔࢱ࣮ࡢᅇ㌿ᦂࡽࡂ࡟࠾ࡅࡿ㠀ᖹ⾮ᛶࡀ཯ᛂືຊᏛ࡟ཬࡰࡍຠᯝ
F1-ATPaseࡣATPࡢຍỈศゎ࢚ࢿࣝࢠ࣮࡟ࡼࡗ࡚ືࡃᅇ
㌿ศᏊ࣮ࣔࢱ࣮࡛࠶ࡾ㸪ࡑࡢ໬Ꮫ-ຊᏛ࢚ࢿࣝࢠ࣮㛫ኚ᥮ຠ⋡ࡢ㧗ࡉࡶ┦ࡲࡗ࡚㸪ືసᶵᵓゎ᫂࡟ྥࡅࡓ◊✲ࡀ⥆ࡅࡽࢀ࡚ࡁࡓࠋ㏆ᖺࡢ୍ศᏊィ࡟ࡼࡿ◊✲࡛㸪ࠕ㍈ཷࡅࠖ࡟┦ᙜࡍࡿ䃐㻟䃑㻟ࢧࣈࣘࢽࢵࢺୖ࡛㉳ࡇࡿຍỈศゎ୰㛫཯ᛂࡢ㏿ᗘࡀ㸪䃐㻟䃑㻟ࡢᵓ㐀ኚ໬ࢆ௓ࡋ࡚ᅇ㌿㍈䃒ࢧࣈࣘࢽࢵࢺ

ᮏ◊✲࡛ࡣ㸪

㸦ᅗ 4b㸧ࡣࠊዲ⇕ᛶ⣽⳦࡟ᏑᅾࡍࡿศᏊ࣮ࣔࢱ࣮࡛࠶ࡾࠊ

ᗘኚ໬࡜࡜ࡶ࡟Țࢧࣈࣘࢽࢵࢺࡢᅇ㌿ゅATPຍỈศゎࡢ㝿࡟ᅇ㌿ࡍࡿF o F 1 ̺ATPྜᡂ㓝⣲ࡢỈ⁐ᛶᡂᗘᦂࡽࡂࡀ࡝ࡢࡼ࠺࡟ኚ໬ࡍࡿ࠿ࢆㄪ࡭ࡿ࡜࡜ࡶ࡟㸪ࡑࢀศ࡛࠶ࡿࠋᮏ◊✲࡛ࡣࠊ᫬⣔ิゎᯒࡸ཯ᛂᣑᩓࣔࢹࣜࣥࢢ

࡟ࡼࡾࣜࣥ㓟ゎ㞳㸪F1⤖ྜATPࡢຍỈศゎ㐣⛬ࡢ཯ᛂືຊ

ࡢほⅬ࠿ࡽࠊF 1 ̺ATPase࡟࠾ࡅࡿ໬Ꮫ̺ຊᏛ࢝ࢵࣉࣜࣥࢢ

Ꮫ࡟ࡶࡓࡽࡉࢀࡿᙳ㡪ࢆㄪ࡭ࡓࠋࡑࡢ㝿㸪୍ศᏊィ ࡛ࡣࡢస⏝࣓࢝ࢽࢬ࣒ࢆ୍ศᏊࣞ࣋ࣝࡢᅇ㌿᫬⣔ิ࠿ࡽ┤᥋ゎほ᫂ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡿࠋ

ᦂࡽࡂࢆ㆑ูࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠸ࡓࡵ㸪㻞㻜㼪㻟㻟䁸㻯ࡲ࡛ࡢᐇ㦂ྍ⬟࡞ᗘ㡿ᇦࡀ㝈ࡽࢀࡿ࡯࠿㸪ຍỈศゎ๓ᚋࡢゅᗘᡃࠎࡣࡇࢀࡲ࡛ࡢ◊✲࡛ࠊ㝵ẁ≧ࡢᅇ㌿᫬⣔ิࢹ࣮ࢱࡢ

ࢹ࣮ࢱࢆࡶ࡜࡟ᩘ⌮ࣔࢹࣝࢆᵓ⠏ࡋ࡚ࢩ࣑࣮ࣗࣞࢩࣙࣥࢆ

୰࡟࠶ࡿゐ፹཯ᛂ᫬ࡢᅇ㌿ఇṆ㐣⛬ࢆᐈほⓗ࡟≉ᐃࡍࡿࡓ⾜࠸㸪୺࡟ゅᗘᦂࡽࡂ࡜ྛ཯ᛂ࡟࠿࠿ࡿ᫬㛫ࢫࢣ࣮ࣝࢆㄪ

࡭ࡓࠋ

duced by temperature increase”, Physical Chemistry Chemical Phys-Ș㻟䃑㻟ୖ࡛໬Ꮫ཯ᛂࡀ㉳ࡇࡿࡲ࡛ࡢ㛫㸪䃒ࡢᅇ㌿ࡣ⣽࠿ics, 3(20): 1872–1880 (2017)ࡃᦂࡽࡂ࡞ࡀࡽ೵Ṇࡋ࡚࠸ࡿࠋࡇࡢࡇ࡜࠿ࡽᅇ㌿ゅᗘ࡟ᑐࡍࡿ⮬⏤࢚ࢿࣝࢠ࣮࣏ࢸࣥࢩࣕࣝ㠃ࢆ໬Ꮫ཯ᛂ࡜࡜ࡶ࡟☜⋡ⓗ࡟ษࡾ᭰࠼ࡿࣔࢹࣝࡀᚑ᮶ࡼࡾ⏝࠸ࡽࢀ࡚࠾ࡾ㸪ࡉࡽ࡟ᡃࠎࡢࢢ࣮ࣝࣉࡣຍỈศゎᚋ࡟㻞㻜䁸⛬ᗘࡢᑠᅇ㌿ࡀ⏕ࡌࡿࡇ࡜ࢆ᫂ࡽ࡟ࡋ㸪ຍỈศゎᚅࡕ࡜ࣜࣥ㓟ゎ㞳ᚅࡕࢆูࠎ
ࡢ࣏ࢸࣥࢩࣕࣝෆࡢ㐠ື࡜ࡋ࡚⤌ࡳ㎸ࢇࡔࠋ௒ᅇࡣ㸪ᗘࡢ␗࡞ࡿ᫬⣔ิࢹ࣮ࢱ࠿ࡽᚓࡓྛ཯ᛂࡢ᫬㛫ࢫࢣ࣮ࣝࢆඖ
࡟άᛶ໬⮬⏤࢚ࢿࣝࢠ࣮ࢆồࡵ㸪ࡇࢀࢆ࣏ࢸࣥࢩࣕࣝษࡾ
᭰࠼⋡࡟ྲྀࡾධࢀࡿࡇ࡜࡛

ᗘࢆኚ࠼ࡓࢩ࣑࣮ࣗࣞࢩࣙࣥ

ࢆྍ⬟࡟ࡋࡓࠋ
ィ⟬ࡢ⤖ᯝ㸪

ᗘୖ᪼࡟క࠸ᅇ㌿ゅᗘᦂࡽࡂࡀ࣏ࢸࣥࢩ

ࣕࣝ࠿ࡽ᝿ᐃࡉࢀࡿᒁᡤ⇕ᖹ⾮ศᕸ࠿ࡽእࢀ࡚࠸ࡁ㸪㠀ᖹ
⾮ᛶࡀ኱ࡁࡃ࡞ࡗ࡚࠸ࡃࡇ࡜ࡀࢃ࠿ࡗࡓࠋࡇࢀࡣ㸪⁐፹⢓ᛶࡢపୗ࡟క࠺Țࢧࣈࣘࢽࢵࢺࡢ᫆ືᗘୖ᪼ࢆࡣࡿ࠿࡟ୖ
ᅇࡿ࣮࣌ࢫ࡛໬Ꮫ཯ᛂ㏿ᗘࡀୖ᪼ࡍࡿࡇ࡜࡛㸪ᒁᡤᖹ⾮⦆࿴ࡋࡁࡿ๓࡟ḟࡢ࣏ࢸࣥࢩࣕࣝ࡬ࡢษࡾ᭰ࢃࡾࡀ㉳ࡇࡗ࡚ࡋࡲ࠺ࡓࡵ࡛࠶ࡿࠋࡇࡢࡇ࡜ࡣ㸪ゅᗘᦂࡽࡂࡢグ᠈ࡀᾘኻࡍࡿࡇ࡜࡞ࡃḟࡢ཯ᛂᚅࡕ㐣⛬࡬⛣⾜ࡍࡿࡇ࡜ࢆព࿡ࡋ㸪ࡑࢀ࡟ࡼࡾ㐃⥆ࡍࡿຍỈศゎᚅࡕ᫬㛫࡜ࣜࣥ㓟ゎ㞳ᚅࡕ᫬㛫ࡢ㛫࡟┦㛵ࡀ⏕ࡌࡿࡇ࡜ࡶ᫂ࡽ࠿࡟࡞ࡗࡓࠋᚑ᮶ࠊຍỈศゎ࡜ࣜࣥ㓟ゎ㞳ࡢ2ࡘࡢࢫࢸࢵࣉࡣ⊂❧࡞࣏࢔ࢯࣥ㐣⛬࡜ࡋ࡚⪃࠼ࡽࢀ㸪ࡑࢀࡽࡢ཯ᛂ㏿ᗘᐃᩘࡣᅇ㌿ゅᗘ೵Ṇ᫬㛫ࡢศᕸࢆ஧㔜ᣦᩘ㛵ᩘ࡛ࣇ࢕ࢵࢺࡍࡿࡇ࡜࡟ࡼࡾぢ✚ࡶࡽࢀ࡚࠸ࡓࠋࡋ࠿ࡋ௒ᅇࡢ⤖ᯝࡣ㸪ᖹ⾮࠿ࡽ኱ࡁࡃእࢀࡓ
≧ἣ࡛ࡣࡇࡢ௬ᐃࡀᡂ❧ࡏࡎṇࡋࡃ཯ᛂ㏿ᗘᐃᩘࢆぢ✚ࡶࡿࡇ࡜ࡀ࡛ࡁ࡞࠸ྍ⬟ᛶࢆ♧၀ࡋ࡚࠸ࡿࠋᐇ㝿࡟㸪㻣㻜䁸㻯௨ୖ࡛ࡢࢩ࣑࣮ࣗࣞࢩ࡛ࣙࣥࡣᅇ㌿೵Ṇ᫬㛫ศᕸࡀ஧㔜ᣦᩘ㛵ᩘ࡛ࣇ࢕ࢵࢺࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠿ࡗࡓࠋࡇࡢ࡯࠿࡟ࡶ㸪ࣜࣥ㓟ゎ㞳㐣⛬࡛ࡣ ᗘୖ᪼࡟ࡘࢀ཯ᛂᚅࡕ᫬㛫୰ࡢᅇ㌿ゅᗘศᕸࡀ཯ᛂάᛶ໬⮬⏤࢚ࢿࣝࢠ࣮㞀ቨࡢ㧗࠸㡿ᇦ࡟ᒁᅾࡋ࡚࠸ࡃࡇ࡜࡟ࡼࡾ㸪ᅇ㌿೵Ṇ᫬㛫ศᕸ࠿ࡽᚓࡽࢀࡿぢ࠿ࡅୖࡢ཯ᛂ㏿ᗘᐃᩘࡀ
Arrhenius࡞ᗘୖ᪼࡜࡜ࡶ࡟ᢚไࡉࢀ㸪non-ᗘ౫Ꮡᛶࡀ⌧ࢀࡿࡇ࡜ࡶศ࠿ࡗ࡚࠸ࡿࠋ

௨ୖ࠿ࡽ㸪ᮏ◊✲࡛ࡣ㸪ᖹ⾮࠿ࡽእࢀࡓ⏕యศᏊ⣔࡛ࡣ
Arrhenius๎࠿ࡽእࢀࡓ

ᗘ౫Ꮡᛶ࡜non-Markovian࡞཯ᛂືຊᏛࡀ⏕ࡌࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽ㸪௒ᅇࡢࣔࢹࣝタᐃ࡛ࡣ㸪ᮏ᮶ࠊከ⮬⏤ᗘ࡛グ㏙ࡉࢀࡿࡣࡎࡢศᏊ
࣮ࣔࢱ࣮ࡢ㐠ືࢆ↓⌮ࡸࡾ 1 ⮬⏤ᗘ࡟ⴠ࡜ࡋࡓ࠺࠼࡛㸪ࡉࡽ࡟ศᏊࡢᰂࡽ࠿ࡉ࡟┦ᙜࡍࡿ࣏ࢸࣥࢩࣕࣝᖜࡶ ᗘ࡟ࡼࡽࡎ୍ᐃ࡜௬ᐃࡋ࡚ィ⟬ࢆ⾜ࡗ࡚࠸ࡿࠋ௒ᚋࡣ㞃ࢀࡓ⮬⏤ᗘࡢຠᯝࡀᐇຠᦶ᧿ಀᩘࡸ࣏ࢸࣥࢩࣕࣝᖜ࡟࡝ࡢࡼ࠺࡞ᙧ
࡛ྲྀࡾධࢀࡽࢀࡿ࠿ࢆㄪ࡭㸪ࢱࣥࣃࢡ㉁ࡢ⢓ᙎᛶࢆ⪃៖ࡋࡓࡼࡾṇ☜࡞ࣔࢹࣝ໬ࡢᥦ᱌ࢆ┠ᣦࡍ࡜࡜ࡶ࡟㸪ᅇ㌿㐠ື᫬ࡢȘ㻟䃑㻟 ࢧࣈࣘࢽࢵࢺෆࡢ⇕ᩓ㐓࡟ࡘ࠸࡚ࡶ㆟ㄽࡋࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ
1) Y. Tamiya, R. Watanabe, H. Noji, C. Li and T. Komatsuzaki: “Effects of non-equilibrium angle fluctuation on F1-ATPase kinetics in-ᅗ 5㸸(a)㛤ⰼ๓㸦ᕥ㸧࡜ᡂ⇍ᚋ㸦ᕥ㸧ࡢ㔝⏕ᆺ࠾ࡼࡧ ftsh4ࠋftsh4
ࡢⰼࡣྠࡌⰼᗎࡢࡶࡢࡔࡀࠊࡑࡢⴟ∦ࡢࢧ࢖ࢬࡣከᵝ࡛࠶ࡿࠋ(b)(c)୺ᡂ㛗᪉ྥ࡟࠾ࡅࡿ✵㛫ⓗኚືࠋ㔝⏕ᆺࡢ୺ᡂ㛗᪉ྥ㸦PDG㸹ⓑ⥺㸧(b)࡜ 24 ᫬㛫㛫㝸࡛ࡢᡂ㛗ࢆィ⟬ࡋࡓ ftsh4 (c)ࡢⴟ∦⣽⬊㸦ୗẁ㸧ࠋⴟ∦⣽⬊ࡀ♧ࡍ 24 ᫬㛫ࡢᡂ㛗㛫㝸࡛ࡢ᭱኱ᡂ㛗᪉ྥ࡟࠾ࡅࡿ᫬✵㛫ኚື㸦▮༳㸧ࠋⓑ⥺ࡢ᪉ྥࡣ᭱኱ᡂ㛗ࡢ᪉ྥࢆ♧ࡋ࡚࠸ࡿࠋⓑ⥺ࡢ㛗ࡉࡣࡑࡢ᪉ྥ࡟࠾ࡅࡿᡂ㛗ࡢつᶍࢆ♧ࡋ࡚࠸ࡿࠋゎᯒ࡛ࡣᡂ㛗⥺㸦ⓑ⥺㸧ࡀ⾲♧ࡉࢀࡓ⣽⬊ࡢࡳࢆ⏝࠸ࡓࠋ(d)-(e)48᫬㛫࡟ࢃࡓࡿ᫬㛫ᖹᆒ໬ࠋ0㹼48 ᫬㛫ࡢ⣼✚ᡂ㛗ࡢ PDG ࢆィ⟬ࡋࡓࠋ㔝⏕ᆺࡢⴟ∦⣽⬊ࡢ 48 ᫬㛫ࡢ᭱኱ᡂ㛗᪉ྥ(d)ࡣ 24 ᫬㛫ࡢ᭱኱ᡂ㛗᪉ྥ(b)࡟࠾ࡅࡿ✚⟬⤖ᯝ࡛࠶ࡾࠊࡼࡾ༠ㄪⓗ࡛࠶ࡿࠋftsh4
ࡢⴟ∦⣽⬊(e)ࡣࠊ48 ᫬㛫࡛⤫ྜࡉࢀࡓ PDG ࡀᖹ⾜࡟࡞ࡗ࡚࠸࡞࠸
୰࡛ࠊ㔝⏕ᆺࡼࡾࡶ᫬㛫ᖹᆒ໬ࡢኚືᛶࡀᑡ࡞࠸ࠋ(f)⣽⬊ᡂ㛗ࡣኚືᛶࡀ㧗ࡃࠊ᫬㛫࡟ࡼࡗ࡚ኚ໬ࡍࡿࠋ౛࠼ࡤࠊ⣽⬊ࡢ 24 ᫬㛫ࡈ࡜ࡢ PDG ࡣᕥ࡟ഴ࠸ࡓᚋࠊྑ࡟ഴࡃ࠿ࡶࡋࢀ࡞࠸ࠋ᫬㛫࠾ࡼࡧ✵㛫࡟ࡼࡿኚ໬ࡣ⣽⬊ኚືࢆᖹᆒⓗ࡟ࡍࡿࡓࡵࠊ౛࠼ࡤ 48 ᫬㛫࡟ࡼࡿ⣼✚ᡂ㛗࡛ࡣᆒ୍࡞ჾᐁࢆ㠀ᖖ࡟つ๎ⓗ࡟సࡾฟࡍࠋROS㸦ྑᅗࡢⴟ∦ୖ㒊㸧ࡀ⣽⬊ࡢᡂ⇍ࠊ⣽⬊ศ⿣ࡢ⦰ᑠࠊ࠾ࡼࡧᡂ㛗ࡢ೵Ṇࢆಁ㐍ࡍࡿࠋᡂ⇍ࡋࡓ⣽⬊࡟࠾࠸࡚ࠊROS ࡢ⵳✚ࡣඛ➃࡛ጞࡲࡾᗏ࡟
ྥ࠿ࡗ࡚㝆ୗࡋ࡚࠸ࡃ㸦ྑᅗࡢⴟ∦ෆ㒊ࡢ▮༳㸧ࠋftsh4 ኚ␗యࡀཎᅉ࡛ࠊࡼࡾ㐜ࡃ࠿ࡘኚືᛶࡢᑡ࡞࠸⣽⬊ᡂ㛗ࠊ⣽⬊ศ⿣ࡢ⦰ᑠࠊ
ᡂ㛗ࡢ᫬✵㛫ᖹᆒ໬ࡢᢚไࠊ࠾ࡼࡧⴟ∦ࢧ࢖ࢬ࡟࠾ࡅࡿ㡹೺ᛶࡢ႙ኻࢆࡶࡓࡽࡍ ROS ࡢቑຍࠊኚືࠊ᪩ᮇࡢ⵳✚ࡀ㉳ࡇࡗ࡚࠸ࡿࠋ

(8) ᳜≀ࡢከᵝ࡞⣽⬊ᡂ㛗࠿ࡽᑟࡃṇ☜࡞ჾᐁᡂ㛗ࡢไᚚჾᐁࡀṇࡋ࠸ࢧ࢖ࢬ࡟฿㐩ࡋࡓࡇ࡜ࢆ࡝ࡢࡼ࠺࡟⣽⬊ࡣࠕ▱ࡿࠖࡢ࠿ࠊࡇࡢၥ㢟ࡢ㞴᫆ᗘࡀ㠀ᖖ࡟㧗࠸࡜⪃࠼ࡽࢀ࡚࠸ࡿ⌮⏤ࡣࠊჾᐁෆࡢ⣽⬊ࡢࣛࣥࢲ࣒࡞ᣲືࡢࡓࡵ࡛࠶

ከᵝᛶࡢᐃ㔞ゎᯒࢆ⾜࠸ࠊftsh4 ኚ␗యࡣ㔝⏕ᆺ࡜ẚ࡭ⴟࡿࠋ౛࠼ࡤࠊ㞄ࡾྜ࠺᳜≀⣽⬊ࡣከࡃࡢሙྜࠊ඲యⓗ࡞ࣃ∦ࡢࢧ࢖ࢬ࡜ᙧࡢ୧᪉࡛ⴭࡋࡃኚືᛶࡀ㧗࠸ࡇ࡜ࢆ᫂ࡽ࠿

ࢱ࣮ࣥ࡜ࡣ␗࡞ࡿ௙᪉࡛ᡂ㛗࠾ࡼࡧศ⿣ࢆࡍࡿࠋࣄ࣮࣐ࣗ

࡟ࡋࡓࠋ࣭ࣥࣇࣟࣥࢸ࢕࢔࣭ࢧ࢖࢚ࣥࢫ࣭ࣉࣟࢢ࣒ࣛࡢᨭ᥼ࡢୗࠊ

᫬✵㛫ࡢ⣽⬊ᡂ㛗ࡢከᵝᛶ࡜ࡑࡢᖹᆒ໬ࡀⴟ∦ࡢᙧ≧ࠊᡃࠎࡣ᳜≀Ꮫ⪅ࠊࢥࣥࣆ࣮ࣗࢱ࣮⛉Ꮫ⪅ࠊ⏕≀≀⌮Ꮫ⪅ࡽᡂ㛗᪉ྥࢆỴࡵࡿ࠺࠼࡛㔜せ࡛࠶ࡿࡇ࡜ࡀุ᫂ࡋࡓࡀࠊ୍

࡜ᅜ㝿ඹྠ◊✲ࢆ⾜࠸ࠊࣔࢹࣝࢩࢫࢸ࣒࡜ࡋ࡚ࢩࣟ࢖ࢾࢼ

᪉࡛ࠊ⣽⬊ࡣ࠸ࡘ࡝ࡢࡼ࠺࡟ᡂ㛗ࢆṆࡵࡿࢱ࢖࣑ࣥࢢࢆ▱ࢬࢼࡢⴟ∦ࢆㄪ࡭ࠊ⣽⬊ࡢᡂ㛗⋡࡞࡝ࡢ᫬✵㛫ከᵝᛶ㸦࠾ࡿࡢ࠿ࠊࡲࡓࠊftsh4 ኚ␗య࡟ぢࡽࢀࡿࢧ࢖ࢬ࠾ࡼࡧᙧ≧ࡼࡧࡑࡢ᫬㛫ᖹᆒ໬㸧ࡀṇࡋ࠸ࢧ࢖ࢬ࡟฿㐩ࡍࡿୖ࡛ᚲせࡢ㧗࠸ኚືᛶࡢཎᅉࡣఱ࠿ࠊ࡜࠸ࡗࡓၥ࠸࡟ᑐࡋ࡚ࡶ⪃ᐹ࡛࠶ࡿ࡜࠸࠺㔜せ࠿ࡘ཯┤ឤⓗ࡞⤖ᯝࢆᑟ࠸ࡓࠋຍ࠼࡚ࠊ

ࡋࡓࠋάᛶ㓟⣲ࡀ⣽⬊ࡢࣛࣥࢲ࣒ᛶ࡜ჾᐁࡢࢧ࢖ࢬࢆไᚚࡋ࡚࠸
ࡿࡇ࡜ࢆ᪂つ࡟Ⓨぢࡋࡓࠋ

FtsH4 ࡓࢇࡥࡃ㉁ࡢኚ␗యࡣάᛶ㓟⣲✀㸦Reactive Oxygen Species. ROS㸧ࢆቑຍࡋࠊⴥࡢᙧែ␗ᖖࢆ㉳ࡇࡍࡇ࡜ᡃࠎࡣAAA-ATPase࡜࣓ࢱࣟࣉࣟࢸ࢔࣮ࢮ(άᛶ୰ᚰ࡟㔠ࡀࡍ࡛࡟▱ࡽࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊROSࡀⴟ∦ࡢᡂ㛗ẁ㝵࡛࡝ᒓ࢖࢜ࣥࡀ㓄ᗙࡋ࡚࠸ࡿࢱࣥࣃࢡ㉁ศゎ㓝⣲㸧ࢆࡶࡘ⭷ࡓࡢࡼ࠺࡟ศᕸࡋ࡚࠸ࡿ࠿ࢆ㔝⏕ᆺ࠾ࡼࡧftsh4 ኚ␗య࡛ホ

ࢇࡥࡃ㉁ࣉࣟࢸ࢔࣮ࢮࡢࡦ࡜ࡘ࡛࠶ࡿFtsH4 ࡜࠸࠺ࡓࢇࡥ

౯ࡋࡓࠋࡑࡢ⤖ᯝࠊ㔝⏕ᆺ࡛ࡣⴟ∦ࡢᡂ㛗࡜࡜ࡶ࡟ࠊROSศࡃ㉁࡟ኚ␗ᑟධࡋࡓftsh4 ኚ␗యࡀࢩࣟ࢖ࢾࢼࢬࢼࡢჾᐁ

ᕸࡀⴟ∦ࡢඛ➃㒊㸦tip㸧࠿ࡽᗏ㒊㸦base㸧࡬ඃ఩࡟ࢩࣇࢺ

ࢧ࢖ࢬࢆኚ໬ࡉࡏࡿࡇ࡜ࢆぢฟࡋࡓ㸦ᅗ 5aཧ↷㸧ࠋⴟ∦ࡢࡋ࡚࠸ࡿ཯㠃ࠊftsh4 ኚ␗య࡛ࡣࡑࡢࡼ࠺࡞ROSศᕸࡢẁ㝵ィ⟬ࣔࢹࣝ࡜ࡋ࡚ࠊⴟ∦ࢆ͆㢼⯪͇࡟ぢ❧࡚࡚ࠊⴟ∦ࡢሙⓗ࡞ࢩࣇࢺࡣ㢧ⴭ࡟ㄆࡵࡽࢀࡎࠊ᪩ᮇࡢᡂ㛗ẁ㝵࡛ࡍ࡛࡟ᡤሙᡤ࡟౫Ꮡࡋ࡚␗࡞ࡿᙎᛶ⋡ࢆࣛࣥࢲ࣒࡟୚࠼࡚㸦ࡕࡻ㸦┦ᑐⓗ࡟㸧㐣๫Ⓨ⌧ࡋࠊROSࡢศᕸࡶⴟ∦࡟Ώࡗ࡚୙ᆒ୍

࠺࡝ࠊ኱ᑠᵝࠎ࡞⣽⬊ࡢ㓄⨨ࡀつ๎ⓗ࡛ࡣ࡞࠸ࡇ࡜࡟┦ᙜ㸧ࠊ࡟ศᕸࡋ࡚࠸ࡿࡇ࡜ࢆ✺ࡁṆࡵࡓࠋࡲࡓࠊᑐ↷ᐇ㦂࡜ࡋ࡚ࠊ࠶ࡿ⣽⬊ෆᅽୗࠊᖹ⾮࡟฿㐩ࡍࡿࡲ࡛⭾ࡽࡲࡏ࡚ࠊ͆ⴟ∦͇࠶ࡿ㓝⣲ࢆ⏝࠸࡚ROSࢆῶᑡࡉࡏࡿࡇ࡜࡛ࠊftsh4 ኚ␗యࡢࡀ࡝࠺࠸࠺ᙧ≧࡟฿㐩ࡍࡿ࠿ࢆホ౯ࡍࡿࣔࢹࣝࢆᵓ⠏ࡋࡓࠋⴟ∦ࡢࢧ࢖ࢬ࣭ᙧ≧ࡀᆒ୍໬ࡉࢀࡿࡇ࡜ࠊ࡞ࡽࡧ࡟㔝⏕ᆺࡇࡢࣔࢹ࡛ࣝࡣࠊᙎᛶ⋡ࢆ᫬㛫✵㛫࡟Ώࡗ࡚ᆒ୍࡟୚࠼ࡿ

࡛ROSࢆῶᑡࡉࡏࡿ࡜ࠊ㏻ᖖࡢ᳜≀࡛Ⓨぢࡉࢀࡓࡶࡢࡼࡾࡶ

ሙྜ࡟ࡣࠊ͆ⴟ∦͇ࡣᆒ୍࡞ᙧ≧࡟฿㐩ࡍࡿࡀࠊึᮇ᫬้࡟

኱ࡁ࡞㸦ᙧ≧ᆒ୍࡞㸧ⴟ∦ࡀ⏕⏘ࡉࢀࡿࡇ࡜ࢆぢฟࡋࡓࠋ࠾࠸࡚ࣛࣥࢲ࣒࡟ᙎᛶ⋡ࢆ୚࠼ࡓࣔࢹ࡛ࣝࡣࠊ࠸ࡧࡘ࡞
͆ኚࡇࢀࡽࡢ▱ぢࢆ⥲ྜࡋ࡚ࠊᡃࠎࡣࠊftsh4 ኚ␗యࡢⴟ∦␗యࡶ࡝ࡁ͇ࡢᙧ≧࡟฿㐩ࡋࠊᙎᛶ⋡ࡢึᮇ✵㛫ศᕸ࡟ᛂࡢࢧ࢖ࢬᆒ୍ᛶࡀᔂࢀࡿཎᅉࡀROSࡢቑຍ࡜㠀୍ᵝ࡞✵㛫ࡌࡓከᵝ࡞ᙧ≧ࢆྲྀࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊᡂ㛗⤒㐣࡜࡜ࡶ࡟ศᕸ࡛࠶ࡿࡇ࡜ࠊ࡞ࡽࡧ࡟ROSࡣⴟ∦ࡢᡂ⇍࡜ᡂ㛗ࡢ೵Ṇࢆ㠀୍ᵝ࡞ᙎᛶ⋡ࢆࣛࣥࢲ࣒࡟᣺ࡾ┤ࡋࡓィ⟬ࣔࢹ࡛ࣝࡣࠊ

ಁࡍෆ⏕ⓗᡂ㛗ไᚚ࡛࠶ࡿࡇ࡜ࢆᥦၐࡋࡓࠋROSࡀ⎔ቃ᮲௳͆ⴟ∦͇ࡣᆒ୍࡞ᙧ≧࡟฿㐩ࡋᚓࡿࡇ࡜ࡀุ᫂ࡋࡓࠋࡇࡢ

࡟ᡂ㛗ࢆ㐺ᛂࡉࡏࡓࡾ⮬㌟ࡢ኱ࡁࡉࢆㄪᩚࡉࡏࡓࡾࡍࡿᛂ

ࡇ࡜ࡣࠊᡂ㛗᫬ࡢࣛࣥࢲ࣒ᛶࡢ᫬✵㛫ᖹᆒ໬ࡀṇᖖ࡞ჾᐁຊࢩࢢࢼࣝ࠾ࡼࡧⓎ㐩ࢩࢢࢼࣝࡢᣦᶆ࡜࡞ࡗ࡚࠸ࡿྍ⬟ᛶࢆᙧᡂࡍࡿ࠺࠼࡛㔜せ࡛࠶ࡿࡇ࡜ࢆ♧၀ࡋ࡚࠸ࡿࠋᐇ㝿ࠊࡀ࠶ࡾࠊ௒ᚋࡢ◊✲ࡀᮇᚅࡉࢀࡿࠋ

ftsh4 ኚ␗యࡣ᫬✵㛫ᖹᆒ໬࡟࠾࠸࡚Ḟ㝗ࡀ࠶ࡿ୍᪉࡛ࠊ

1) L. Hong, M. Dumond, S. Tsugawa, A. Sapala, A. Routier-Kierz-㔝⏕ᆺࡢⴟ∦ࡣࣀ࢖ࢬࡢከ࠸⣽⬊ᡂ㛗ࡢ᫬✵㛫ᖹᆒ໬ࢆ⤒kowska, Y. Zhou, C. Chen, A. Kiss, M. Zhu, O. Hamant, R. S. Smith,࡚࠾ࡾࠊࡑࢀࡽࢆࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢࡸᐃ㔞ⓗᡂ㛗ゎᯒࢆ

T. Komatsuzaki, C. Li, A. Boudaoud and A. H. Roeder : “Variable cell⏝࠸᳨࡚ドࡋࡓࠋ

growth yields reproducible organ development through spatiotem-᭦࡟ࠊᡃࠎࡣ⣽⬊ᡂ㛗ࡀ᫬㛫ⓗ࡟ࡶ✵㛫ⓗ࡟ࡶ 12 ᫬㛫poral averaging”, Developmental Cell, 38(1) : 15-32 (2016)㛫㝸࡛ከᵝ࡛࠶ࡿࡇ࡜ࢆぢ࠸ࡔࡋࡓࠋᑐ↷ⓗ࡟ࠊ48 ᫬㛫㛫2) S. Tsugawa, H. Nathan, O. Hamant, A. Boudaoud, R. S. Smith, C.

㝸࡛⣽⬊࡜ࡑࡢፉ⣽⬊ࡢ⣼✚ᡂ㛗᪉ྥࢆほᐹࡍࡿ࡜ࠊ㔝⏕Li and T. Komatsuzaki : “Extracting subcellular fibrillar alignmentᆺࡢⴟ∦ࡢᡂ㛗᪉ྥࡣⴟ∦⣽⬊ࡢ୺࡞ᡂ㛗᪉ྥ࡜࡯ࡰᆒ୍

with error estimation: Application to microtubules”, Biophysical࡟ᖹ⾜࡟࡞ࡗࡓࠋ୍᪉࡛ࠊኚ␗యࡢⴟ∦ࡣᖹᆒ໬ࣉࣟࢭࢫ

Journal, 110(8) : 1836-1844 (2016)࡛Ḟ㝗ࡀ⏕ࡌ࡚࠸ࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋኚ␗యࡢ⣽⬊ࡣ㔝⏕ᆺࡼࡾࡶᑠࡉ࡞᫬✵㛫ኚືࢆ♧ࡍࡀࠊ48 ᫬㛫㛫㝸ࡢ⣼✚୺ᡂ㛗᪉ྥࡣ㠀ᖖ࡟ከᵝ࡛࠶ࡾࠊ࡞࠾࠿ࡘⴟ∦ࡢ୺࡞ᡂ㛗᪉ྥ࡜ᖹ⾜࡟ࡣ࡞ࡗ࡚࠸࡞࠸㸦ᅗ 5b-eཧ↷㸧ࠋ㸦9㸧ẟ⣽⬊ࡢ࿘ࡾࡢᘬᙇᛂຊ࡬ᚤᑠ⟶ᛂ⟅ࡢᐃ㔞໬᳜≀ჾᐁࡣಶయ࡟౫ࡽࡎ࡯ࡰྠᙧ࣭ྠࢧ࢖ࢬࡢᙧ≧ࢆ⋓ᚓࡍࡿ㦫ࡃ࡭ࡁ┦ྠᛶࡸ෌⌧ᛶࢆᣢࡘ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪⣽ᩘ್ィ⟬ࣔࢹࣝ࡜⣽⬊ቨᙎᛶ ᐃᐇ㦂ࡢ⤖ᯝࡣࠊ㔝⏕ᆺ⬊࡛ࣞ࣋ࣝࡣᙧ≧ࡸࢧ࢖ࢬࡀከᵝ࡛࠶ࡾ㸪᳜≀ࡀ࡝ࡢࡼ࠺

࡛ࡣ⣽⬊ᡂ㛗ࡢከᵝᛶࡀ㧗ࡃࠊftsh4 ኚ␗య࡛ࡣ⣽⬊ᡂ㛗࡟ከᵝᛶࢆࢥࣥࢺ࣮ࣟࣝࡋ࡚᭱⤊ᙧ≧࡟⮳ࡿ࠿ࡣᮍࡔゎ᫂

ࡢከᵝᛶࡀప࠸ྍ⬟ᛶࢆ♧၀ࡋ࡚࠸ࡿࠋࡑࡇ࡛ࠊᡃࠎࡣ㞄ࡉࢀ࡚࠸࡞࠸㸬ᮏ◊✲࡛ࡣ㸪᳜≀ჾᐁ࡟Ⅼᅾࡍࡿẟ⣽⬊(ᅗ᥋⣽⬊⩌ࡢ✵㛫ⓗ࡞ᡂ㛗ከᵝᛶࢆᐃ㔞໬ࡍࡿᡭἲࢆ㛤Ⓨࡋࠊ

6A)ࡀჾᐁࢧ࢖ࢬ࡟୚࠼ࡿᙳ㡪ࢆㄪ࡭࡚࠸ࡿ㸬ຊᏛࢩ࣑ࣗࣞ

ᐇ㝿࡟㔝⏕ᆺࡢ᪉ࡀኚ␗యࡼࡾࡶ✵㛫ⓗ࡞⣽⬊ᡂ㛗ࡢከᵝ࣮ࢩࣙࣥࣔࢹ࡛ࣝணゝࡉࢀࡓẟ⣽⬊ࡢ࿘ࡾࡢᘬᙇᛂຊ࡬ࡢ

ᛶࡀ㧗࠸ࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡲࡓࠊ㔝⏕ᆺ࡜ftsh4 ኚ␗ᚤᑠ⟶ᛂ⟅ࡀ㔝⏕ᆺ࡜ኚ␗య࡛࡝ࡢ⛬ᗘ␗࡞ࡿ࠿ࢆᐃ㔞໬యࡢჾᐁࡢᙧ≧ࢆẚ㍑ࡍࡿࡓࡵ࡟Fourierゎᯒ࡟ࡼࡿᙧ≧ࡍࡿࡇ࡜࡛㸪ᒁᡤⓗ࡞ຊᏛኚ໬ࡀ඲యࡢჾᐁࢧ࢖ࢬ࡟୚࠼

ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡟ᣮᡓࡋࡓ㸬ᩍᤵ ◊✲௦⾲㸧ࠖࡢ◊✲ᡂᯝ࡛࠶ࡿࠋ

ඹྠ◊✲ࢢ࣮ࣝࣉ࡟ࡼࡿ⣽⬊ᅽຊ໬ࣔࢹࣝ࡟ࡼࡾ㸪ࢥࣥ1) N. Hervieux, S. Tsugawa, A. Fruleux, M. Dumond, A. Routier-ࣆ࣮ࣗࢱୖࡢ௬᝿ẟ⣽⬊࡟ᑐࡋ࡚ෆഃ࠿ࡽ⭾ᅽࢆ᝿ᐃࡋࡓ

Kierzkowska, T. Komatsuzaki, A. Boudaoud, J. C. Larkin, R. S. Smith,ᅽຊࢆ୚࠼㸪࿘ࡾࡢ⣽⬊ࡢ⾲㠃ᛂຊࢆㄪ࡭ࡓ࡜ࡇࢁ㸪ẟ⣽

C. Li and O. Hamant: “Mechanical Shielding of Rapidly Growing⬊ࡢ࿘ࡾ࡟෇≧ࡢᛂຊࢿࢵࢺ࣮࣡ࢡࡀᵓ⠏ࡉࢀࡿࡇ࡜ࡀ᫂

Cells Buffers Growth Heterogeneity and Contributes to Organ Shapeࡽ࠿࡟࡞ࡗࡓ㸬ࡇࡢ⤖ᯝࡢཎᅉ࡜ࡋ࡚ࡣ㸪1)⣽⬊ࡢᛴ⃭࡞

Reproducibility”, Current Biology, 27(22): 3468–3479 (2017)⭾ᅽኚ໬࡟㉳ᅉࡍࡿሙྜ㸪࠶ࡿ࠸ࡣ 2)⭾ᅽ୍ᐃୗ࡛⣽⬊ࡢ⾲㠃ࡀ㌾໬ࡋ࡚ᛴ⃭࡟ᡂ㛗ࡍࡿሙྜࡢ㸰ࡘࡀ⪃࠼ࡽࢀࡿࡀ㸪㸦10㸧1 ⣽⬊࣐ࣛࣥ࢖࣓࣮ࢪࣥࢢ᝟ሗ⌮ㄽⓗゎᯒᡭἲࡢ㛤ࢩ࣑࣮ࣗࣞࢩࣙࣥୖࡣ࡝ࡕࡽࡢሙྜࡶ㸦㸰ࡢሙྜࡣ⣽⬊඲

Ⓨ⏕⣽⬊ࡢRaman㢧ᚤ㙾⏬ീࡣ⣽⬊඲యࠊ౛࠼ࡤ⭷⤌⧊ࡸయ࡬ࡢᙇຊࡀᚲせ࡛࠶ࡿࡀ㸧ẟ⣽⬊࿘ࡾ࡟෇≧ࡢᛂຊᵓ㐀ࡀ⌧ࢀࡿࡇ࡜ࡀᩘ್ᐇ㦂ࢆ᥼⏝ࡋ࡚☜࠿ࡵࡽࢀࡓ㸬᰾࡜࠸ࡗࡓ⣽⬊ࢆᡂࡍᵓᡂせ⣲ࠊࡑࢀ࠿ࡽ⬡㉁ࠊࢱࣥࣃࢡ

᳜≀⣽⬊ࡣᛂຊᵓ㐀࡟㉳ᅉࡋ࡚ᚤᑠ⟶ษ᩿ࢱࣥࣃࢡ㉁㉁ࠊ᰾㓟࡞࡝ࡢ⣽⬊ᡂศࢆᙧసࡿᵓᡂせ⣲࡞࡝࡟ࡘ࠸࡚ࡢ

Kataninࡀᶵ⬟ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾ㸪ᚤᑠ⟶ࡣᛂຊ᪉ྥ

᝟ሗࢆ㇏ᐩ࡟ྵࢇ࡛࠸ࡿࠋࡇࡢࡼ࠺࡟ከࡃࡢ᝟ሗࢆ᫂ࡽ࠿

࡟୪ࢇ࡛㓄ྥࡍࡿࡇ࡜ࡀከࡃࡢᐇ㦂࡛᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡿ㸬࡟ࡋ࡚࠸ࡿ࡟ࡶ㛵ࢃࡽࡎࠊ⌧ᅾࡢRaman⏬ീࡢศᯒᡭἲࡣࠊ

ᡃࠎࡣ㔝⏕ᆺ(WT)㸪ᚤᑠ⟶㔜ྜ໬Ḟ㝗ኚ␗య(bot1-7)㸪ᚤᑠ

ほ⟶㔜ྜ໬ಁ㐍ኚ␗య(spr2-2)ࡢ 3 ࡘࡢኚ␗యࡢẟ⣽⬊ࡢ࿘౛࠼ࡤࠊ࢔࣏ࢺ࣮ࢩࢫࡢ┤๓࡟࣑ࢺࢥࣥࢻࣜ࢔⭷࠿ࡽࢩࢺࡾࡢᚤᑠ⟶㓄ྥゅᗘࢆᐃ㔞໬ࡋࡓ㸦ᅗ 6B-E㸧㸬ࡑࡢ⤖ᯝ㸪

ࢡ࣒ࣟcࡀᨺฟࡉࢀࡿࡇ࡜ࡀほᐹࡉࢀ࡚࠸ࡿࡀࠊ࣑ࢺࢥࣥࢻ

ẟ⣽⬊ࡢ㏆࠸㏆ഐ࡛㸪ẟ⣽⬊ࡢฟ⌧┤๓ࡢᚤᑠ⟶㓄ྥࡣ㸪ࣜ࢔ࡣᒁᅾ໬ࡸྠᐃࡢຓࡅ࡜࡞ࡾᚓࡿࡑࡢ௚ከࡃࡢ໬Ꮫ✀WT࡜spr2-2 ࡣ࡯࡜ࢇ࡝ྠ⛬ᗘࡢ෇≧㓄ྥᗘ࡛࠶ࡗࡓࡀ㸪ࢆྵࢇ࡛࠸ࡿࠋࡑࡢࡓࡵࠊࢩࢺࢡ࣒ࣟc࠿ࡽ⏕ࡌࡿᑡᩘࡢࢫ

bot1-7 ࡣ෇≧࡟㓄ྥࡋ࡚࠸࡞࠸ࡇ࡜ࡀࢃ࠿ࡗࡓ㸬୍᪉࡛㸪࣌ࢡࢺࣝ≉ᛶࢆ⏝࠸ࡿࡢ࡛ࡣ࡞ࡃࠊ⣽⬊ᡂศࡢศ㢮࡟࠾ࡅ

spr2-2 ࡛ࡣẟ⣽⬊ࡀฟ⌧ࡋࡓᚋࡶ෇≧ࡢ㓄ྥࢆ⥔ᣢࡋ࡚࠸ࡿ඲ࢫ࣌ࢡࢺࣝࢆ⏝࠸ࡿࡇ࡜ࡀ᭷┈࡜ゝ࠼ࡿࠋࡉࡽ࡟ࠊᡃࠎ

ࡿࡇ࡜ࡶ☜࠿ࡵࡽࢀࡓ㸦ᅗ 6F㸧㸬ࡲࡓࡑࡢഴྥࡣ㸪ẟ⣽⬊ࡣ⣽⬊ࢫ࣌ࢡࢺࣝࡢศ㢮࡟᝟ሗ⌮ㄽࢆά⏝ࡋࡓࠋࡍ࡞ࢃࡕࠊ

ࡢ㐲࠸㏆ഐ࡟࠾࠸࡚ࡶㄆࡵࡽࢀࡓ㸦ᅗ 6G㸧㸬ࡍ࡞ࢃࡕ㸪bot1-

࣮ࣞࢺṍ⌮ㄽ࡟ࡼࡿࢡࣛࢫࢱࣜࣥࢢࢆ⏝࠸ࡿࡇ࡜࡛ࠊィ

7 ࡣᚤᑠ⟶ᛂ⟅ࡀᙅࡃ㐜࠸ࡓࡵ㸪෇≧㓄ྥࡀẟ⣽⬊㏆ഐ࡛ㄗᕪࡢᩘ࠶ࡿཎᅉࡢᐃ㔞໬࠾ࡼࡧ⤌ࡳ㎸ࡳࢆࡍࡿࡇ࡜࡛ࠊ

ࡶᙧᡂࡉࢀࡎ㸪spr2-2 ࡣᚤᑠ⟶ᛂ⟅ࡀᙉࡃ᪩࠸ࡓࡵ㸪෇≧㞧㡢ࢆྵࡴRamanࢫ࣌ࢡࢺࣝࡢศ㢮ࡢ⢭ᗘࢆ᱁ẁ࡟㧗ࡵࡿ࡟ࡼࡗ࡚ᚓࡽࢀࡿ᝟ሗࡢ࡯ࢇࡢᑡࡋࡋ࠿ᢅࡗ࡚࠸࡞࠸ࠋ

㓄ྥࡀ㛗ࡃ㐲ࡃࡲ࡛⥔ᣢࡉࢀࡿ࡜⤖ㄽ࡙ࡅࡽࢀࡿ㸬
㸦8㸧
㸦9㸧ࡣ㟁Ꮚ⛉Ꮫ◊✲ᡤࡀᏛ⾡༠ᐃࢆ⥾⤖ࡋ࡚࠸ࡿࣜࣚ
ࣥ㧗➼ᖌ⠊Ꮫᰯࢆྵࡵࡓࣄ࣮࣐࣭ࣗࣥࣇࣟࣥࢸ࢕࢔࣭ࢧ࢖
࢚ࣥࢫ࣭ࣉࣟࢢ࣒ࣛ

ࢢࣛࣥࢺ㈹ ◊✲ㄢ㢟ྡࠕFrom sto-

chastic cell behavior to reproducible shapes: the coordination behind morphogenesis㸦ࣜࣚࣥ㧗➼ᖌ⠊Ꮫᰯ

Arezki Boudaoudᅗ 6㸬A)ࢩࣟ࢖ࢾࢼࢬࢼⴟ∦ࡢẟ⣽⬊㸬B)ᚤᑠ⟶㓄ྥࡢ෇≧㓄ྥᗘࡢᐃ㔞໬᪉ἲࡢᴫᛕᅗ㸬C-E㸧㔝⏕ᆺ࡜ኚ␗యࡢᚤᑠ⟶㓄ྥࡢ෇≧㓄ྥᗘࡢ✵㛫ศᕸ㸬F-G㸧෇≧㓄ྥᗘࡢẚ㍑(F:10um20um, G:20um-30um)㸬

ᅗ 7㸸✵㛫ⓗ࡟ࢥࣄ࣮ࣞࣥࢺ࡞⣽⬊㡿ᇦ࡟♧ࡉࢀࡿ⒴ᛶ࠾ࡼࡧ
㠀⒴ᛶࡢࣄࢺࡢ℞⬊⏥≧⭢⣽⬊ࡢ Raman 㢧ᚤ㙾⏬ീࡢࢫ࣌ࢡ
ࢺࣝࡢศ㢮ࠋෆ㒊ࡢ≉Ṧ࡞⣽⬊⎔ቃࢆ♧ࡍ a) ℞⬊⏥≧⭢⒴⣽⬊࡜ࠊb) ࣄࢺࡢ℞⬊⏥≧⭢⣽⬊ࠋࡇ࡜ࡀ࡛ࡁࡓࠋᅗ 7 ࡛ࡣࡑࢀࡒࢀࡢࢫ࣌ࢡࢺࣝࡢࢡࣛࢫࢱ
ࡀⰍศࡅࡉࢀ࡚࠾ࡾࠊ℞⬊⏥≧⭢⒴⣽⬊(ᅗ 7a)࡜ࣄࢺࡢ℞⬊⏥≧⭢⣽⬊(ᅗ 7b)ࡢ⠊ᅖࡀ✵㛫ⓗ࡟ࢥࣄ࣮ࣞࣥࢺ࡞㡿ᇦ࡟ศ㢮ࡉࢀ࡚࠾ࡾࠊࡑࢀࡒࢀࡀ࠾࠾ࡼࡑ໬Ꮫⓗ࡟≉Ṧ࡞⣽⬊⎔ቃࢆ♧ࡋ࡚࠸ࡿࠋࡇࡢ⤖ᯝࢆ㋃ࡲ࠼ࠊ⌧ᅾࡢ◊✲࡛ࡣࡑࢀࡒࢀࡢࢡࣛࢫࢱࡀ⣽⬊ࡈ࡜࡟༨ࡵࡿ㔞࡟↔Ⅼࢆᙜ࡚ࡿ
ࡇ࡜࡛ࠊ⒴ᛶ࠾ࡼࡧ㠀⒴ᛶࡢ⣽⬊ࢆ㆑ูࡍࡿᡭἲࡢᥦ᱌ࢆ
┠ᣦࡍࠋ
㸦11㸧ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝࢦࣜࢬ࣒ࡢ㛤Ⓨ⑓ẼࡸᶵᲔࡢᨾ㞀ࡢデ᩿࡞࡝࡛ࡣࠊ࡝ࡇ࠿୍⟠ᡤ࡛ࡶ␗ᖖࡀ࠶ࡿ࡜ၥ㢟ࡀ࠶ࡿࡶࡢ࡜デ᩿ࡉࢀࡿࠋࡑࡢࡼ࠺࡞デ᩿࡛ࡣࠊ᭱ึ࡟␗ᖖࡀぢࡘ࠿ࡗࡓ᫬Ⅼ࡛デ᩿ࢆᡴࡕษࡗ࡚ࠊ
␗ᖖ࠶ࡾ࡜⤖ㄽ࡙ࡅࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡇࡢࡼ࠺࡞␗ᖖࡢ࠶
ࡿ࡞ࡋࢆ࡛ࡁࡿࡔࡅ㏿ࡃデ᩿ࡍࡿၥ㢟ࡣࠊ⭎ࢆᘬࡃẖ࡟ྛ⭎ࡈ࡜࡟ᅛ᭷࡞༊㛫[0,1]ୖࡢศᕸ࡟ᚑ࠸ᦆኻࢆ⿕ࡿࠊᦆኻ∧K⭎ࣂࣥࢹ࢕ࢵࢺタᐃ࡟࠾࠸࡚ࠊᦆኻᖹᆒࡀ࠶ࡿ㜈್௨ୖ࡛࠶ࡿ⭎ࡀᏑᅾࡍࡿ࠿ྰ࠿ࢆࠊ࡛ࡁࡿࡔࡅᑡ࡞࠸ヨ⾜ᅇᩘ(⭎ࢆᘬࡃᅇᩘ)ุ࡛ᐃࡍࡿࠕᝏ⭎Ꮡᅾࢳ࢙ࢵࢡၥ㢟ࠖ࡜ࡋ࡚ᐃᘧ໬࡛ࡁࡿࠋ

ᅗ 8㸸ேᕤࢹ࣮ࢱ࡟ࡼࡿࢩ࣑࣮ࣗࣞࢩࣙࣥᐇ㦂ࡢ⤖ᯝǼ ț  ࠋᦆኻࡀ࣋ࣝࢾ࣮࢖ศᕸ࡟ᚑ࠺ 100 ⭎ࡢ࠺ࡕ m ⭎ࢆᖹᆒᦆኻࡀ㜈್ࡼࡾࡶ኱ࡁ࡞⭎࡜ࡋࠊ100-m ⭎ࢆᖹᆒᦆኻࡼࡾࡶᑠࡉ࡞⭎࡜ࡋࠊAPT-BCࠊLUCB-BCࠊUCB-BC ࡢ 100 ᅇᐇ⾜ࡋࡓᖹᆒ೵Ṇ᫬้࡜ࡑࡢ 95%ಙ㢗༊㛫ࢆࢢࣛࣇ࡟ࡋࡓࠋྛ
ࢢࣛࣇࡢࢱ࢖ࢺࣝࡣ㜈್ ȟ ࡜ṇ⭎ࡢಶᩘ m ࢆ⾲ࡍࠋ

㸦12㸧࣐ࣛࣥ㢧ᚤศග⏬ീࡢᶵᲔᏛ⩦ⓗ࢔ࣉ࣮ࣟࢳ
ᶵᲔᏛ⩦࡟ࡼࡿࢹ࣮ࢱศᯒࢆ⤌ࡳྜࢃࡏࡓ࣐ࣛࣥศග
ᐃࡣࠊ⏕యࡢ␗࡞ࡿ≧ែࡢ⤌⧊࡟࠾ࡅࡿ࣐ࣛࣥࢫ࣌ࢡࢺࣝ

ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡၥ㢟࡛ࡣࠊ୚࠼ࡽࢀࡓࢢࣞ࢖ࢰ࣮ࣥᖜ

ࡢ㐪࠸ࢆヲ⣽࡟ศᯒࡍࡿᙉຊ࡞デ᩿ࢶ࣮ࣝ࡜ᡂࡾᚓࡿࠋ≉ǼѮ(0,0.5)࡜㜈್䃗䌜㻔䂴㻘㻝-䂴㻕࡟ᑐࡋࠊᦆኻᖹᆒ䃛ࡀ䃗㻗䂴࡟ࠊᶆⓗ࡜࡞ࡿ⑓Ẽࡢࣂ࢖࣐࣮࣮࢜࢝ࡀ≉ᐃࡉࢀ࡚࠸࡞࠸

ࡼࡾ኱ࡁࡅࢀࡤṇࡢ⭎ࠊ䃗-䂴ࡼࡾᑠࡉ࡞ሙྜࡣ㈇ࡢ⭎࡜ࡍࡼ࠺࡞ሙྜ࡟ࡶ㔜せ࡜࡞ࡾ࠺ࡿࠋ࡞ࡐ࡞ࡽࠊ࣐ࣛࣥ࢖࣓࣮

ࡿࠋ୚࠼ࡽࢀࡓチᐜㄗࡾ☜⋡䃓䌜㻔㻜㻘㻜㻚㻡㻕࡟ᑐࡋࠊṇࡢ⭎ࡀᏑࢪࣥࢢࡣ≉ᐃࡢศᏊ࡟㛵ࡍࡿᵓ㐀࠾ࡼࡧ໬Ꮫ᝟ሗࢆࡶࡓࡽ

ᅾࡍࡿሙྜ࡟ࡣ 1-䃓௨ୖࡢ☜⋡࡛ࠕṇࠖࠊ㈇ࡢ⭎ࡋ࠿Ꮡᅾࡍࡔࡅ࡛ࡣ࡞ࡃࠊศᯒࡋࡓࢧࣥࣉࣝ඲యࡢ᝟ሗࢆࡶࡶࡓࡽ

ࡋ࡞࠸ሙྜࡣ 1-䃓௨ୖࡢ☜⋡࡛ࠕ㈇ࠖ࡜ฟຊࡍࡿ࢔ࣝࢦࣜ

ࡍࡓࡵࠊ࠶࠼࡚࣐࣮࣮࢝⺮ⓑ㉁࡟ࡼࡗ࡚ྠᐃࡍࡿᚲせࡀ࡞ࢬ࣒ࢆ㻔䂴㻘䃓㻕-ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝࢦࣜࢬ࣒࡜࿧ࡧࠊ࡛ࡁ

࠸࠿ࡽ࡛࠶ࡿࠋ

ࡿࡔࡅヨ⾜ᅇᩘࡀᑡ࡞࠸㻔䂴㻘䃓㻕-ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝࢦ

ࡇࡢ࣐ࣛࣥศග

ᐃ࡟ࡼࡿデ᩿࡟࠾࠸࡚ࠊ㐺ษ࡞ࢹ࣮ࢱ

ࣜࢬ࣒ࢆ㛤Ⓨࡍࡿࡇ࡜ࢆ┠ᶆ࡜ࡍࡿࠋࡇࡢタᐃ࡟㏆࠸◊✲࣐࢖ࢽࣥࢢἲࡢ㛤Ⓨࡀせ࡜࡞ࡿࠋࡑࡇ࡛ࠊ࣐ࣛࣥಙྕ࡟ෆ

࡜ࡋ࡚ࠊ㜈್ࣂࣥࢹ࢕ࢵࢺၥ㢟࡜᭱Ⰻ⭎㆑ูၥ㢟ࡀ࠶ࡿࠋᅾࡍࡿศᏊࡢࢫ࣌ࢡࢺࣝᕪࢆཧ↷ࡍࡿࡇ࡜࡟ࡼࡾࠊᇶᮏⓗᝏ⭎Ꮡᅾࢳ࢙ࢵࢡၥ㢟ࡀᑡ࡞ࡃ࡜ࡶ୍ࡘṇࡢ⭎ࢆぢࡘࡅࢀ࡞⤌⧊ᆺࠊ⑌⑓ࡢẁ㝵ࢆ⌮ㄽⓗ࡟㆑ูࡍࡿ࢔ࣝࢦࣜࢬ࣒ࡢ

ࡤ࠸࠸ࡢ࡟ᑐࡋ㸪㜈್ࣂࣥࢹ࢕ࢵࢺၥ㢟ࡣࡍ࡭࡚ࡢṇ࡜㈇ࣉࣛࢵࢺࣇ࢛࣮࣒ࢆᡃࠎࡣ㛤Ⓨࡋ࡚࠸ࡿࠋ≉࡟ᡃࠎࡣࡢ⭎ࢆṇࡋࡃ༊ูࡋ࡞ࡃ࡚ࡣ࠸ࡅ࡞࠸ࠋࡲࡓࠊ᭱Ⰻ⭎㆑ู

㸦CMDSࡶࡋࡃࡣISOMAPࡢࡼ࠺࡞)ḟඖ๐ῶࡸࠊศ㢮࡟ᇶၥ㢟ࡣࠊᦆኻᖹᆒࡀ㜈್ࡼࡾࡶ㧗࠸⭎࡛ࡣ࡞ࡃࠊ᭱ࡶ㧗࠸࡙ࡃ࢔ࣥࢧࣥࣈࣝᏛ⩦(ࣛࣥࢲ࣒ࣇ࢛ࣞࢫࢺ)ࢆ⾜࡞ࡗ࡚࠸⭎ࢆ≉ᐃࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࠋ

ࡿࠋḟඖ๐ῶࡣ㐶࠿࡟ᑡ࡞࠸ḟඖ࡛㧗ḟඖࢹ࣮ࢱ࡟ෆᅾࡍ

ᮏ◊✲࡛ࡣ㻔䂴㻘䃓㻕-ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝࢦࣜࢬ࣒࡟࠾

ࡿᵓ㐀ࢆ᥈ࡿࡇ࡜ࢆྍ⬟࡟ࡋࠊ࠿ࡘࠊࢹ࣮ࢱࢆྍど໬ࡍࡿ࠸࡚ࠊࢢࣞ࢖ࢰ࣮ࣥᖜ䂴ࡀ࠶ࡿ⛬ᗘ኱ࡁ࠸ሙྜ࡟ࠊ⭎ࡢṇࡇ࡜࡛␗࡞ࡿ⤌⧊≧ែ࡟ᑐᛂࡍࡿࢡࣛࢫࢱࣜࣥࢢࢆ⾜࠼ࡿࠋ㈇ࡢุᐃࢆᑡ࡞࠸ࢧࣥࣉࣝᩘ࡛⾜࠼ࡿ⭎ุᐃつ๎ࢆࡶࡘ࢔

ࡲࡓࠊࣛࣥࢲ࣒ࣇ࢛ࣞࢫࢺࡣ࣐ࣛࣥࢫ࣌ࢡࢺࣝࡢᵓ㐀ࢆᏛࣝࢦࣜࢬ࣒ࡢࢧࣥࣉࣝ」㞧ᗘࡢศᯒࢆ⾜ࡗࡓࠋࡲࡓࠊ㜈್⩦ࡍࡿࡇ࡜࡟ࡼࡾࠊࢫ࣌ࢡࢺࣝࡢ≉ᚩ࠿ࡽ᭱ࡶ㛵㐃ࡢ࠶ࡿࣂࣥࢹ࢕ࢵࢺၥ㢟࡟ᑐࡍࡿ᪉⟇APTࢆᝏ⭎Ꮡᅾࢳ࢙ࢵࢡၥ

ࢡࣛࢫࢱࢆぢฟࡍࡶࡢ࡛࠶ࡿࠋ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫⫢⑌ᝈ㢟࡟ྜࢃࡏ࡚ᨵⰋࢆ⾜ࡗࡓAPT-BC࡜᭱Ⰻ⭎㆑ูၥ㢟࡟ᑐ

(NAFL)ࡢ⥺⥔⑕ࢆண

ࡍࡿLUCB᪉⟇ࢆ⭎㑅ᢥ᪉⟇࡜ࡋࡓLUCB-BC࡟ຍ࠼㸪⣼✚ῶ࠾ࡼࡧࣛࣥࢲ࣒ࣇ࢛ࣞࢫࢺࢆ࣐ࣛࣥ࢖࣓࣮ࢪࣥࢢ࡟ᑐࡋ

ሗ㓘᭱኱໬ၥ㢟࡟ᑐࡍࡿUCB᪉⟇ࢆ⭎㑅ᢥ᪉⟇࡜ࡋ࡚᥇࡚ᐇ⾜ࡍࡿࡇ࡜࡛ࠊࡲࡔ⑓⌮ࡀほᐹࡉࢀ࡚࠸࡞࠸ึᮇẁ㝵⏝ࡋࡓUCB-BCࢆᐇ⾜ࡋࡓ㝿ࡢ೵Ṇࡲ࡛ࡢࢧࣥࣉࣝᩘࢆࠊ

࡛ࡶ⤌⧊≧ែࢆぢศࡅࡿデ᩿ࡢ⬟ຊྥୖ࡟⧅ࡀࡗࡓࠋ

ࡍࡿࣛࢵࢺࣔࢹࣝࢆ⏝࠸࡚ࠊḟඖ๐ࢩ࣑࣮ࣗࣞࢩࣙࣥᐇ㦂࡟ࡼࡾẚ㍑ࢆ⾜ࡗࡓ㸦ᅗ 8㸧ࠋࡇࡢᐇࡲࡓࠊ⑌⑓ࡢ␗࡞ࡿẁ㝵ࢆ㆑ูྍ⬟࡞≉ᚩⓗ࡞࣐ࣛࣥࢫ

㦂࡛ࡣAPT-BCࡢᖹᆒ೵Ṇ᫬้ࡀ࠸ࡘࡶ᭱ࡶ᪩࠿ࡗࡓࠋࡲ

࣌ࢡࢺࣝࡢ࿘ἼᩘࢆྠᐃࡋࠊNAFLࡢ≧ែࢆ 2 ࡘ࡟ศ㢮ࡋࡓṇࡢ⭎ࡀከ࠸࡜ࡁ࡟ࡣࡑࡢᕪࡣ㢧ⴭ࡛࠶ࡗࡓࠋࡇࢀࡣࠊ

ࡓࠋ1 ࡘࡀᏳᐃⓗ࡞NAFL࡛ࠊࡶ࠺ 1 ࡘࡀNAFL࡟㐍⾜୰ࡢ

LUCB-BCࡸUCB-BCࡀ」ᩘࡢṇࡢ⭎ࢆከࡃ㑅ᢥࡋ࡚ࡋࡲ

㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖(NASH)࡛࠶ࡿࠋNAFLࢫ࣌ࢡࢺ࠺ࡢ࡟ᑐࡋࠊAPT-BCࡣ୍ࡘࡢṇࡢ⭎ࢆ㞟୰ࡋ࡚ᘬࡃഴྥ

ࣝࡣ㏻ᖖᆺ࠾ࡼࡧNASHࡢ୧᪉࡜኱ࡁࡃ㔜」ࡋ࡚࠸ࡿ㒊ศࡀ࠶ࡿࡓࡵࡔ࡜⪃࠼ࡽࢀࡿࠋ

࡜␗࡞ࡗ࡚࠸ࡿ㒊ศࡢ୧᪉ࡀほᐹࡉࢀࠊ୙ᆒ୍ᛶࡀぢࡽࢀࡋ࡚࣮ࣜࢲ࣮ⓗ࡞ᙺ๭ࢆᢸ࠸ୖ⓶⤌⧊ࡢ඲యᛶࢆಖࡕࡘࡘ

࡚࠸ࡿࠋࡶࢥࣟࢽ࣮ࡢቃ┠࠿ࡽฟ࡚ࡁ࡚࠸ࡿᵝᏊࡀ᫂ࡽ࠿࡟࡞ࡗ࡚

ᡃࠎࡢᡭἲ࡛ࢧࣥࣉࣝ࡟ෆᅾࡍࡿ⏕໬Ꮫⓗ᝟ሗࢆᢳฟࡍ

࠸ࡿࠋ᭱㏆ࡢ◊✲࡛ࡣࠊ㐟㉮ࢥࣟࢽ࣮ࡢ୰࡛࣮ࣜࢲ࣮⣽⬊ࡿࡇ࡜࡟ࡼࡾࠊNAFLࡢ␗࡞ࡿ≧ែࢆ㆑ูࡍࡿࡓࡵࡢࣂ࢖

࡟ඛᑟࡉࢀ࡚㉳ࡇࡿᮎ➃࡛ࡢ✺㉳ࡢⓎ⏕ࡢࡁࡗ࠿ࡅ࡜࡞ࡿ

࣐࣮࣮࢜࢝ࡀ≉ᐃྍ⬟࡛࠶ࡾࠊࡲࡓࣛࣥࢲ࣒ࣇ࢛ࣞࢫࢺศ

⏕యศᏊࡀ♧ࡉࢀࡓࠋࡋ࠿ࡋࠊ࣮ࣜࢲ࣮⣽⬊ࡢฟ⌧ࡢ⫼ᚋ㢮ჾࢆ⏝࠸࡚ࠊ
ࠕṇᖖࠖ࠿ࠕ㠀ṇᖖࠖ࠿ࠊࡶࡋࡃࡣࠕNAFLࠖ࡟࠶ࡿ≀⌮ⓗ⌧㇟ࡣࠊᮍࡔ⌮ゎࡀ῝ࡲࡗ࡚࠸࡞࠸ࠋୖ⓶⣽࠿ࠕ㠀NAFLࠖ࠿ࢆศࡅࡿ㔜せ࡞Ἴᩘࢆゎ᫂ࡋࠊࡑࡢἼᩘࡣ

⬊ࡢ㞟ᅋ㐠ື࡟࠾ࡅࡿ࣮ࣜࢲ࣮⣽⬊ฟ⌧᫬ࡢ≀⌮ⓗ⌧㇟ࡢ୺࡟⬡㉁࡜⺮ⓑ㉁࡟㛵㐃ࡍࡿࡇ࡜ࢆ♧ࡋࡓ㸦ᅗ 9㸧ࠋ
ࠕNASHࠖ

ኚ໬ࢆ⌮ゎࡍࡿࡓࡵ࡟ࠊᡃࠎࡣ㌾ࢥ࣮ࣛࢤࣥࢤࣝᇶ㉁ࡢୖ

࡛ࡣ⬡㉁ࡢ኱㔞⵳✚࡟ࡼࡾࠊࠕ㠀NASHࠖ࡜ࡣࢱ࢖ࣉࡢ␗࡞

࡛ᇵ㣴ࡉࢀࡓMDCKୖ⓶ࢩ࣮ࢺࡢ఩┦ᕪ㢧ᚤ⏬ീࡢ⤒᫬ኚ໬ࡿ⬡㉁࡟࡞ࡗ࡚࠸ࡿྍ⬟ᛶࡀ࠶ࡿࠋࡇࡢデ᩿᪉ἲࡀࠊࣛࢵ

㸦⏕࿨⼥ྜ⛉Ꮫࢥ࣮ࢫⰾ㈡Ọᩍᤵࡽ࡟ࡼࡾᥦ౪㸧࠿ࡽᚓࡽࢺࣔࢹࣝࡢNAFLࡢ⥺⥔⑕ࡢண࡟ᑐࡋ࡚᪂ࡓ࡞ࢶ࣮ࣝ࡜

ࢀࡓ㏿ᗘሙ࡟╔┠ࡋࡓࠋಶࠎࡢ⣽⬊㏣㊧࡟≉᭷ࡢᢏ⾡ⓗၥ࡞ࡾ࠼ࠊࡦ࠸࡚ࡣࣄࢺࡢ⬡⫫⫢⑌ᝈࡢศᯒ࡟㠀ᖖ࡟᭷ຠ࡜

㢟㸦⏬ീ⣔ิࡸ⣽⬊ศ⿣ࡢ⺯ගࢥࣥࢺࣛࢫࢺࡢ୙୍⮴㸧ࢆ࡞ࡾᚓࡿ࡜⪃࠼࡚࠸ࡿࠋ

㑊ࡅࡿࡓࡵ࡟ࠊࡇࡇ࡛ࡣୖ⓶⤌⧊ࡢ㏿ᗘሙࡣ⢏Ꮚ⏬ീ㏿ᗘ(10)-(12)ࡣ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ࣭ᡓ␎ⓗ๰㐀◊✲᥎㐍஦ᴗ
/CRESTࠕ᝟ሗィ ࠖ㸪ࠕ୍⣽⬊࣐ࣛࣥィ

ᐃ(PIV)ᢏ⾡ࢆ⏝࠸࡚ᚓ࡚࠸ࡿࠋᐇ㝿࡟ࠊPIVࡣ㐃⥆⏬ീ࡜᝟ሗ⛉Ꮫࡢ⼥ྜࡢ┦஫┦㛵࠿ࡽᒁᡤኚ఩࣋ࢡࢺࣝࢆᢳฟࡋ࡚࠾ࡾࠊ㏻ᖖࠊ

࡟ࡼࡿ⣽⬊デ᩿ࡢ㎿㏿ゎᯒᢏ⾡ࡢ㛤Ⓨࠖ㸦H28-33㸪ᑠᯇᓮẸὶయຊᏛ࡛⏝࠸ࡽࢀ࡚࠸ࡿࠋ఩┦ᕪ㢧ᚤ㙾ࡢ⏬ീࡢᵓ㐀ࡢᶞᩍᤵ௦⾲㸧ࡢᡂᯝ࡛࠶ࡿࠋ

࠾࠿ࡆ࡛ࠊᡃࠎࡢ◊✲࡛ࡣᐇ㦂⣔࡟ᚤᑠ࡞ࢺ࣮ࣞࢧ࣮ࢆຍ࠼ࡿᚲせࡣ࡞࠸ࠋ
ᅗ 10 ࡣPIVศᯒ࠿ࡽᚓࡽࢀࡓ㏿ᗘሙࡢ௦⾲ⓗ࡞ࢫࢼࢵࣉ
෗┿࡛࠶ࡿࠋࢥࣟࢽ࣮࡛✺㉳ࡀ㉳ࡇࡿ๓࡟ࠊ⣽⬊ࡣࡸࡸ༠ാⓗ࡛ࡣ࡞࠸㐠ືࢆࡋ࡚࠾ࡾࠊ࡜ࡶࡍࢀࡤࠊ୙つ๎࠿ࡘ᫬࡟ࡣᅇ㌿ࡍࡿࡼ࠺࡞ືࡁࢆぢࡏ࡚࠸ࡓࡇ࡜ࡀほࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊ࣮ࣜࢲ࣮⣽⬊ࡀ⌧ࢀࡓᚋࡣࠊࡇࡢศᯒ࡛ほࡉࢀࡓࡼ࠺࡟ࠊ⣽⬊⩌ࡢ⣽⬊ࡀ࣮ࣜࢲ࣮⣽⬊ࡢ᪉ྥ࡟ἢ
ࡗ࡚༠ാⓗ࡟㐠ືࡋ࡚࠸ࡿࠋPIVᢏ⾡࡛ᚓࡽࢀࡓ㏿ᗘሙ࡟ᇶ࡙ࡁࠊ᫬㛫ࡈ࡜ࡢ㏿ᗘࡢ኱ࡁࡉࡢศᕸࢆィ⟬ࡋࡓࠋ✺㉳ࡀ⌧ࢀࡿ๓ࡢึᮇẁ㝵࡜ẚ࡭ࡿ࡜ࠊࢥࣟࢽ࣮࡛✺㉳ࡀ⌧ࢀࡓᚋ㸦ほࢆጞࡵ࡚࠿ࡽ 35 ᫬㛫ᚋ㸧࡛ࡣศᕸࡀᗈࡀࡿࡇ࡜ࡀ

ศ࠿ࡗࡓࠋࡇࢀࡣࠊ㧗࠸ྍືᛶࢆ♧ࡍ࣮ࣜࢲ࣮⣽⬊࡟ඛᑟࡉࢀ࡚ቃ⏺࠿ࡽᣦ≧࡟๓࡟ฟࡿ≧ែࡀฟ⌧ࡋࠊࡉࡽ࡟ࠊࣜ
࣮ࢲ࣮⣽⬊ࡣࣇ࢛࣮ࣟ࣡⣽⬊࡜࢝ࢻ࣊ࣜࣥ࡟ࡼࡾ௰௓ࡉࢀࡓ᥋ゐࢆᙉࡃಖࡗ࡚࠸ࡿ࠿ࡽ࡛࠶ࡿࠋࡑࡢࡓࡵࠊ⾲㠃ࡢ๓㌟ࡢ㛫ࡶࣇ࢛࣮ࣟ࣡⣽⬊ࡶ㧗࠸ྍືᛶࢆ♧ࡋࠊ⤖ᯝ࡜ࡋ࡚ᣦ≧✺㉳ࡀ⌧ࢀࡓᚋࡣᖹᆒ㏿ᗘࡀୖ᪼ࡋ࡚࠸ࡿࠋከḟඖᑻᗘᵓᡂἲࢆ⏝࠸࡚ࠊᡃࠎࡣ࣮ࣜࢲ࣮⣽⬊ࡀࢥࣟࢽ࣮࡟ฟ⌧ࡋጞࡵࡿ㝿࡟ࠊ㏿ᗘࡢ኱ࡁࡉࡢศᕸࡀ࠶ࡿࢡࣛࢫࢱ࠿ࡽู
ࡢࢡࣛࢫࢱ࡟ኚ໬ࡍࡿ࡜࠸࠺ࡇ࡜ࢆⓎぢࡋࡓࠋᡃࠎࡣࠊࢥ
ࣟࢽ࣮࡟࠾ࡅࡿ࣮ࣜࢲ࣮⣽⬊ࡢฟ⌧ࡀほࡉࢀࡿ௚ࡢ㢮ఝࡢᐇ㦂࡟࠾࠸࡚ࡶࠊ௒ᅇࡢ⤖ᯝ࡜ᩚྜࡍࡿ⤖ᯝࡀᚓࡽࢀࡿ
ᅗ 9㸸ࠕṇつᆺࠖᑐࠕ㠀ṇつᆺࠖ㸦ୖẁ㸧ࠊࠕNAFLࠖᑐࠕ㠀 NAFLࠖ㸦୰ẁ㸧ࠊࠕNASHࠖᑐࠕ㠀 NASHࠖ㸦ୗẁ㸧࡟࠾ࡅࡿ㔜せ࡞≉ᛶࠋࡔࢁ࠺࡜⪃࠼࡚࠸ࡿࠋ

㸦13㸧⣽⬊ࡢᙺ๭ศ໬ࡢࢹ࣮ࢱ⛉Ꮫ㞟ᅋⓗ⣽⬊㐠ືࡣࠊ౛࠼ࡤࠊ⬇Ⓨ⏕ࠊ⒴㌿⛣ࠊ๰യ἞⒵࡜࠸ࡗࡓࠊ࠸ࡃࡘ࠿ࡢ⏕≀Ꮫⓗ㐣⛬ࡢ୰࡛ᴟࡵ࡚㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿࠋ0DGLQ̺'DUE\࢖ࢾ⭈⮚(MDCK)ୖ⓶⣽⬊ࡢ㞟ᅋ㐠ື᫬࡟ࠊ✺ዴ⌧ࢀࡓ≉Ṧ໬ࡋࡓ࣮͆ࣜࢲ࣮͇࡜࿧
ࡤࢀࡿ⣽⬊ࡀ͆ࣇ࢛࣮͇ࣟ࣡࡜࿧ࡤࢀࡿ࿘㎶ࡢ⣽⬊⩌࡟ᑐᅗ 10, ௦⾲ⓗ࡞㏿ᗘ࣐ࢵࣉ㸸㏿ᗘ࣐ࢵࣉࡣୖ⓶⣽⬊ࡢୖࡢࡳ࡛ࣉࣟࢵࢺࡋ࡚࠾ࡾࠊ㌾ࢥ࣮ࣛࢤࣥᇶ㉁ୖࡢᇵ㣴ࡉࢀࡓ MDCK⣽⬊ࡢ఩┦ᕪ㢧ᚤ㙾ࡢ⏬ീࡢୖ࡟㔜ࡡ࡚ᥥ࠿ࢀ࡚࠸ࡿࠋ

࢖ࢡࣜࢵࢡAMP⃰ᗘࢆࡓ࡝ࡿࡇ࡜࡟ࡼࡾࠊ࣮ࣜࢲ࣮࠾ࡼࡧ
㸦14㸧࢔࣓࣮ࣂ࡟࠾ࡅࡿ࣮ࣜࢲ࣮ࣇ࢛ࣟ࢔࣮⣽⬊ࡢᙺ๭ศࣇ࢛࣮ࣟ࣡⣽⬊㛫࡛ࡢ࢚ࣥࢺࣟࣆ࣮ࡢ⛣ືࡀ࣮ࣜࢲ࣮⣽⬊໬≉ᐃࡢࡓࡵࡢ᭷ຊ࡞ࢶ࣮ࣝ࡜࡞ࡿࠋ⛣ື࢚ࣥࢺࣟࣆ࣮ࡀ㠀⣽⬊ࡢ㞟ᅋ㐠ືࡣࠊ౛࠼ࡤࠊ⒴ࡢᡂ㛗ࠊ๰യ἞⒵ࠊჾᐁ

ᑐ⛠ࡀ࠶ࢀࡤࠊ࣮ࣜࢲ࣮-ࣇ࢛࣮ࣟ࣡㛵ಀࡀ⏕ࡌ࡚࠸ࡿ࡛࠶

Ⓨ⏕࡜࠸ࡗࡓከࡃࡢ⏕≀Ꮫⓗ㐣⛬࡟࠾࠸࡚㔜せ࡛࠶ࡿࠋ༢

ࢁ࠺ࡇ࡜ࢆព࿡ࡋ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊ኱ࡁ࡞⣽⬊⩌ࡢ⣽⬊⏕≀ࡢࢥࣟࢽ࣮ࠊ౛࠼ࡤ࢔࣓࣮ࣂDictyostelium dis-୰࡛ࡢ⛣ື࢚ࣥࢺࣟࣆ࣮ࡢ౑⏝࡟ࡣ࠸ࡲࡔㄢ㢟ࡀṧࡗ࡚࠾coideum(Dicty)ࡣࠊࣄࢺ⤌⧊ࢆ⌮ゎࡍࡿୖ࡛ࡢᮃࡲࡋ࠸≉ᛶࡾࠊ᭦࡞ࡿࢹ࣮ࢱࡀᚲせ࡜࡞ࡿࠋࡑࡢࡓࡵࠊ⌧ᅾࠊ኱つᶍࢆ᭷ࡋ࡚࠸ࡿࠋࡇࡢ◊✲࡛ࡣ᝟ሗ⌮ㄽⓗほⅬ࠿ࡽࡑࡢࢩࢫ

ࢹ࣮ࢱࢭࢵࢺࡢ⮬ື⢏Ꮚ㏣㊧ἲ࡟ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

ࢸ࣒ࢆศᯒࡍࡿࡇ࡜࡛ࠊ⣽⬊จ㞟ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ᣦࡍࠋຍ࠼࡚ࠊࢩࢫࢸ࣒ෆ࡛ࡢ᝟ሗఏ㐩ࢆ◊✲ࡍࡿࡇ࡜࡛ࠊ

㸦15㸧᫬㛫ศゎἲࢆ⏝࠸ࡓࠊ⤌⧊῝㒊ࡢ⺯ගࢱ࣮ࢤࢵࢺ࢖

⣽⬊ࡢᙳ㡪ࡢᐃ㔞໬ࠊ࣮ࣜࢲ࣮࠾ࡼࡧࣇ࢛࣮ࣟ࣡⣽⬊ࡢศ࣓࣮ࢪࣥࢢᡭἲࡢ㛤Ⓨ㢮ࠊ࿨௧ࢆୗࡍ㝿ࡢ࣮ࣝࣝࡢ⌮ゎࢆྍ⬟࡜ࡍࡿࠋ࢞ࣥ࡞࡝ࡢ⑓ኚ㒊ࢆᨺᑕᛶࣉ࣮ࣟࣈ࡟ࡼࡾ㧗ឤᗘ࡟᳨ฟ

Dicty⣽⬊ࡣࢧ࢖ࢡࣜࢵࢡAMP࡜࿧ࡤࢀࡿ໬Ꮫ≀㉁ࢆᨺ

ࡍࡿ᪉ἲࡀᐇ⏝໬ࡋ࡚࠸ࡿࡀࠊ⿕᭚ࡸ≉Ṧ࡞᪋タࢆᚲせ࡜ฟࡍࡿࡇ࡜࡟ࡼࡾ㐃⤡ࢆྲྀࡾྜ࠺ࡀࠊࡇࡢࢧ࢖ࢡࣜࢵࢡ

ࡍࡿ࡞࡝ၥ㢟ࡀከ࠸ࠋᨺᑕᛶࣉ࣮ࣟࣈࢆ⺯ගࣉ࣮ࣟࣈ࡞࡝

AMPࡣᬑ㐢ⓗ࡞໬Ꮫ≀㉁࡛࠶ࡾࠊ౛࠼ࡤࣄࢺ࠾ࡼࡧື≀ࡢ࡟⨨ࡁ᥮࠼ࡿࡇ࡜࡟ࡼࡾࡑࢀࡽࡢၥ㢟ࡣゎᾘ࡛ࡁࡿ࡜⪃࠼⫢⮚࡟࠾࠸࡚⢾㢮ࢆATP࡟ኚ᥮ࡍࡿᙺ๭ࢆᢸࡗ࡚࠸ࡿࡶࡢ

ࡽࢀࡿࡀࠊ⤌⧊࡟ᇙࡵ㎸ࡲࢀࡓ⺯ගࣉ࣮ࣟࣈࡢ᳨ฟࡣᴟࡵ

࡛࠶ࡿࠋDicty⣽⬊ࡣࢧ࢖ࢡࣜࢵࢡAMPࡢ໙㓄࡟㏆࡙ࡃࡇ࡜࡚㞴ࡋ࠸ࠋࡇࢀࡣ⏕య⤌⧊ࡀᙉ࠸ᩓ஘྾཰ࢆᣢࡘࡓࡵ࡛࠶

࡛࡟཯ᛂࡋࠊࡉࡽ࡟ࢧ࢖ࢡࣜࢵࢡAMP⮬యࢆᨺฟࡍࡿࠋ⤖ࡿࠋࡋ࠿ࡋගᏊ᳨ฟࢩࢫࢸ࣒࡜ࣃࣝࢫ࣮ࣞࢨ࣮ࢆ⏝࠸ࡓ㧗ᯝ࡜ࡋ࡚ࠊ཯ᛂᣑᩓ⣔࡛᭷ྡ࡞࣋ࣟ࢘ࢯࣇ࣭ࢪࣕ࣎ࢳࣥࢫ

࠸᫬㛫ศゎ⬟ࢆᣢࡘィ࣮࢟཯ᛂࡢࡼ࠺࡞ࠊ⣽⬊⩌ࢆ㏻ࡿࡽࡏࢇἼࡢࣃࢱ࣮ࣥࢆ⏕࣮ࣟࣈ࡟ࡘ࠸࡚ࡶ᳨ฟྍ⬟࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡗ࡚ࡁ࡚࠸ࡿࠋ

ࡳฟࡍࡇ࡜࡜࡞ࡿࠋࡇࡢࡼ࠺࡞ࡽࡏࢇἼࡣᚰ୙ᩚ⬦ࡢࡼ࠺ࡋ࠿ࡋࠊᐇ㝿࡟ࡑࡢ✵㛫ⓗศᕸࢆ▱ࡿ࠸ࢃࡺࡿ⺯ගࢺࣔࢢ࡞ᚰ⮚ࡢ␗ᖖࢆᘬࡁ㉳ࡇࡍ஦ࡶ▱ࡽࢀ࡚࠸ࡿࠋࡼࡗ࡚Dictyࣛࣇ࢕ᡭἲࡣࠊ⌧ᅾࡶ◊✲㏵ୖ࡟࠶ࡿࠋᮏ◊✲࡛ࡣࠊ᫬㛫⣽⬊ࢆ⌮ゎࡍࡿࡇ࡜ࡣࠊ⣽⬊ࡢ㞟ᅋ㐠ືࡢ⌮ゎࢆຓࡅࡿࡔ

ศゎ⺯ග᳨ฟࢩࢫࢸ࣒ࡢ㛤Ⓨ࡜ࡑࡇ࠿ࡽࡢ᫬㛫ᛂ⟅ࢹ࣮ࢱࡅ࡛࡞ࡃࠊ⏕య⣔࡟࠾ࡅࡿࡽࡏࢇἼࡢฟ⌧ࢆ⌮ゎࡍࡿࡇ࡜ࢆ⏝࠸ࡓ⺯ගࢺࣔࢢࣛࣇ࢕ᡭἲࡢ㛤Ⓨ࡜ࢆ⾜ࡗࡓࠋ࡟⧅ࡀࡿࠋ࡟ࡼࡾࠊ῝ࡉ㸯㹡㹫⛬ᗘࡢ⺯ගࣉ⺯ගࡢࢺࣔࢢࣛࣇ࢕ࢆ⾜࠺ࡓࡵ࡟ࡣࠊ」ᩘࡢ✵㛫ⓗ࡟␗┤㏆࡛ࡣDicty⣽⬊ࢆᐇ㦂࡜ࢩ࣑࣮ࣗࣞࢩࣙࣥࡢ୧᪉࠿

࡞ࡿⅬ࡟࠾࠸࡚⺯ගࡢ᫬㛫ᛂ⟅㛵ᩘࢆィࡍࡿࠋ᫬㛫ᛂ⟅ࡽ◊✲ࡋࡓࠋᐇ㦂࡛ࡣࠊᅗ 11 ࡟♧ࡋࡓࡼ࠺࡟ࠊDicty⣽⬊㛵ᩘ࡟ࡣࠊ⺯ගࣉ࣮ࣟࣈࡢ⺯ගῶ⾶≉ᛶ࡜࡜ࡶ࡟⤌⧊ෆࢆࡢจ㞟࡟ࡼࡿ⣔ࡢኚ໬ࢆㄪ࡭ࡿࡓࡵࠊ⢏Ꮚ⏬ീὶ㏿ ᐃࢆఏ᧛ࡋࡓග㊰࡟㛵ࡍࡿ᝟ሗࡀྵࡲࢀࡿࠋࡇࢀࡽ࡟ᑐࡋࠊග

⏝࠸࡚㏿ᗘሙࢆ⟬ฟࡋࡓࠋจ㞟㐣⛬ࡢⓎ⏕࡟ࡘࢀ࡚㏿ᗘࡀఏ᧛ࡢᩘ⌮ࣔࢹࣝࢆసࡾࠊࡑࡢ⤖ᯝ࡜ẚ㍑ࡋࡑࡢᕪࡀᑠࡉ

ࡲࡍࡲࡍ✵㛫ⓗ࡟┦㛵ࡍࡿࡓࡵࠊShannon࢚ࣥࢺࣟࣆ࣮࡟ࡼ

ࡃ࡞ࡿࡼ࠺࡞᧯సࢆ⾜࠸⏬ീࢆᚓࡿࠋ௒ᅇࡣࠊගఏ᧛ࢆ㍺ࡿจ㞟ࡢண

㏦᪉⛬ᘧ࡛グ㏙ࡍࡿ୍᪉ࠊບ㉳ගࡣ୍ᵝ࡞༙✵㛫ࡢ፹య࡛ࡀྍ⬟࡛࠶ࡿࡇ࡜ࢆⓎぢࡋࡓࠋຍ࠼࡚ࠊ⣽⬊ࡢจ㞟ࡀጞࡲࡿ࡜᫬㛫࡜ඹ࡟ࠕ඾ᆺⓗࠖ࡜ࠕ㠀඾ᆺⓗࠖࡢࡢ㏆ఝⓗ࡞ゎᯒᘧࢆ⏝࠸࡚༢⣧໬ࡋࡓࠋᐃ⩏ࡀኚࢃࡿࡓࡵࠊ୍㐃ࡢ඾ᆺᛶࡢᡭἲ࡟ࡼࡾᩘ᫬㛫๓࡟จ㞟ࢆணࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋࡉࡽ࡟ࡣࠊಶูࡢ⣽⬊ࡢࢧ࢔ࣝࢦࣜࢬ࣒ࢆ☜ㄆࡍࡿࡓࡵ࡟ࠊࣔࣥࢸ࢝ࣝࣟἲ࡟ࡼࡾ
ගఏ᧛ࢆࢩ࣑࣮ࣗࣞࢩࣙࣥࡋࠊࡑࡢ⤖ᯝࢆࢹ࣮ࢱ࡜ぢ❧࡚⏬ീ෌ᵓᡂࢆ⾜ࡗࡓࠋࢩ࣑࣮ࣗࣞࢩ࡛ࣙࣥࡣ༙✵㛫ࡢ⤌⧊ࢆ⪃࠼ࠊࡑࡢ୰࡟⌫ᙧࡢ⺯ගࢱ࣮ࢤࢵࢺࢆタ⨨ࡋࡓࠋ༙✵㛫ࡢ⾲ഃࡢ4⟠ᡤ࡛㡰࡟ගࢆධࢀࠊ12⟠ᡤࡢ᳨ฟⅬ࡛⺯ගࢆほࡋࡓ࡜ࡋࡓࠋࡑࢀ࡟ࡼࡿ෌ᵓᡂ⏬ീࢆᅗ12࡟♧ࡋࡓࠋ

ᅗ12ࡢ AࠊB ࡣྛࣆࢡࢭ࡛ࣝࡢ⺯ගࢱ࣮ࢤࢵࢺࡢ྾཰ಀᩘ
࡟ไ㝈ࢆ୚࠼࡞࠸࠸ࢃࡺࡿࣆࢡࢭ࣮ࣝ࣋ࢫࡢ⏬ീ෌ᵓᡂࡢ
⤖ᯝ࡛࠶ࡿࠋ㉥ࡢ୸ࡣ┿ࡢ఩⨨ࢆ♧ࡍࠋࣆࢡࢭ࣮ࣝ࣋ࢫࡢ
⤖ᯝ࡟࠾࠸࡚ࡶࠊ┿ࡢീ࡟㏆࠸ศᕸࢆ෌ᵓᡂࡍࡿࡇ࡜ࡀ࡛
ࡁࡓࡀࠊ್ࡣᑠࡉࡃࡲࡓศᕸࡣᗈࡀࡗ࡚࠸ࡿࠋࡇࡇ࡟ࠊ⺯ගࢱ࣮ࢤࢵࢺ࡛ࡢ್ࡢศᕸࡀ࡞࠸࡜ࡋ2್໬ࡍࡿࡼ࠺࡞ᣊ
᮰ࢆᑟධࡋࠊ࠸ࢃࡺࡿࣞ࣋ࣝࢭࢵࢺἲ࡟ࡼࡾ⏬ീࢆ෌ᵓᡂ
ࡋࡓ⤖ᯝࡀ C,D ࡛࠶ࡿࠋ2್໬ࡋゎࢆไ㝈ࡍࡿࡇ࡜࡟ࡼࡾ
⏬ീࡣ኱ᖜ࡟ᨵၿࡋࠊࡲࡓ್⮬㌟ࡶ┿್࡟㏆࡙࠸ࡓࠋ௒ᚋࡣࠊᐇ㝿ࡢᐇ㦂ࢹ࣮ࢱࢆ⏝࠸ࡓ⏬ീ෌ᵓᡂࢆ㐍ࡵࡿࡓࡵ࡟ࠊࡼࡾィ⟬௜ຍࡀᑡ࡞࠸ࠊᣑᩓ᪉⛬ᘧ࡛ࡢගఏᦙࣔ
ᅗ 11㸸Dicty ⣽⬊ࡢ඾ᆺⓗ࡞จ㞟㐣⛬ࢹࣝࢆ⏝࠸ࡿ࡜࡜ࡶ࡟ࠊᏳᐃ࡛ࣟࣂࢫࢺ࡞࢔ࣝࢦࣜࢬ࣒ࡢ

ᵓ⠏ࢆ┠ᣦࡍࠋ

ࡢධᑕ࡜ࣆࢥ⛊ࣃࣝࢫ࣮ࣞࢨ࣮࡜ࡢྠ᫬ධᑕࡢ⤖ᯝࢆ♧ࡋ1) K.Prieto, and G.Nishimura, “A new scheme of the time-domain

࡚࠸ࡿࠋCW࣮ࣞࢨ࣮ࡢࡳࡢධᑕࡢሙྜ࡟ẚ࡭ࣃࣝࢫ࣮ࣞࢨ

fluorescence tomography for a semi-infinite turbid medium.” Opt.Rev.

࣮ධᑕࡢሙྜࡣ᣺ᖜࡀῶᑡࡍࡿ࡜࡜ࡶ࡟ࠊࣃࣝࢫගࡢ⧞ࡾ

24, 242-251, (2017)㏉ࡋ࿘ᮇ࡟ᑐᛂࡍࡿ᣺ືࡀぢࡽࢀࡿࠋ㊥㞳ࡀቑຍࡍࡿ࡜ᩓ
஘ᅇᩘࡀቑຍࡍࡿࡓࡵ┦㛵㛵ᩘࡢῶ⾶ࡣ㏿ࡃ࡞ࡗ࡚࠸ࡿࠋA (yz ᖹ㠃)50

B (z ᖹ㠃)0.104

x=26mm

40
30

10

0.102

20

0.101

0.099

40

0.098

50

30
y [mm]

40

50

50

30
x [mm]

40

0.098

50

య࡜⪃࠼ࡓ࡜ࡁࡢゎᯒゎࢆྜࢃࡏࡿࡇ࡜࡟ࡼࡾࠊ࢖ࣥࢺࣛ

D (z ᖹ㠃)0.26

x=26mm0.24

40ࣜࣆࢵࢻ⁐ᾮࡢගᏛᐃᩘࢆỴᐃࡍࡿࡇ࡜ࡀฟ᮶ࡓࠋࡇࢀࢆ

50

0.26

z=40mm

0.2

0.22
30

0.16
0.14

10

0.12
10

20
30
y [mm]

4050㛗ࡢᙳ㡪ࢆྲྀࡾ㝖࠸ࡓῶ⾶᫬㛫ࢆᚓࡿ஦ࡀ࡛ࡁࡓࠋࡇࡢῶ

0.2

0.18
20

┦㛵㛵ᩘࡢゎ࡟ධࢀࢹ࣮ࢱ࡟ᙜ࡚ࡣࡵࡿࡇ࡜࡟ࡼࡾࠊග㊰

0.24

40

0.22

30

0

ࡋࡓ᫬㛫ᛂ⟅≉ᛶࡣᅗ13(ྑ)࡟♧ࡉࢀ࡚࠸ࡿࠋ༙↓㝈፹

0.099
20

࡟ࣃࣝࢫ࣮ࣞࢨ࣮

ගࡀᙳ㡪ࡋ࡚࠸࡞࠸ࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋ୍᪉ࠊྠ᫬࡟ィ

0.1

10

C (yz ᖹ㠃)ධᑕ࡜୍⮴ࡍࡿࡇ࡜࠿ࡽࠊගᏊ┦㛵ィ

0.102

30

0.1

10
20

0.103

0.101

20

10

ࣃࣝࢫගࢆධᑕࡋࡓሙྜ࡛ࡶࠊ┦㛵㛵ᩘࡢῶ⾶ࡣCWࡢࡳࡢz=40mm

0.103

0.18
20

⾶᫬㛫ࡣࠊ༑ศⷧࡵ༢ᩓ஘᮲௳ୗ࡛ᚓࡽࢀࡓῶ⾶᫬㛫࡜ẚ

0.16
0.14

10

㍑ࡍࡿࡇ࡜ࡀ࡛ࡁࠊ࡯ࡰ್ࡀ୍⮴ࡋࡓࠋࡇࡢࡇ࡜࠿ࡽྠ᫬

0.12

0.1
0

10

20
30
x [mm]

40

50

0.1

ᐃ࡟ࡼࡾከ㔜ᩓ஘ࡢᙳ㡪ࢆྲྀࡾ㝖ࡁ┦㛵㛵ᩘࢆゎᯒ࡛ࡁ

ᅗ 12 ࣔࣥࢸ࢝ࣝࣟࢩ࣑࣮ࣗࣞࢩࣙࣥࢹ࣮ࢱ࡟ᑐࡍࡿࠊ⏬ീ෌ᵓᡂ౛ࠋA,B ࡣࣆࢡࢭ࣮ࣝ࣋ࢫࡢ⏬ീ෌ᵓᡂ౛ࠊCD ࡣࡉࡽ࡟ࣞ࣋ࣝࢭࢵࢺἲࢆ⏝࠸࡚ 2 ್໬ࡋࡓ⏬ീ෌ᵓᡂ౛ࠋ

ࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋ
ᐇ㝿ࡢ⏕య⤌⧊࡛ࡣࠊ྾཰ࡀ኱ࡁࡃኚ໬ࡍࡿࠋࡑࡢࡓࡵࠊග㊰㛗ࡣྠ୍⤌⧊࡛ࡶኚ໬ࡋࡲࡓಶయ㛫ࡢᕪࡶ኱ࡁ࠸ࠋࡑ
ࡢࡓࡵࠊከ㔜ᩓ஘ࡢᙳ㡪ࢆ᤼ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡇ࡜ࡣᴟࡵ

(16) ගᏊ᳨ฟࢩࢫࢸ࣒ࢆ⏝࠸ࡓ⏕య⤌⧊ࡢᩓ஘ගࡺࡽ

࡚᭷⏝࡛࠶ࡿ࡜⤖ㄽ࡛ࡁࡿࠋࡇࡢᡭἲࢆ⏝࠸⏕య⤌⧊ࡢᩓࡂ஘యࡢືⓗ࡞ᛶ㉁ࡢゎᯒ࡬࡜ᛂ⏝ࡋ࡚⾜ࡃணᐃ࡛࠶ࡿࠋ

ᐃࡢ◊✲⤌⧊࡛ࣞ࣋ࣝࡢᩓ஘ගᦂࡽࡂィ ࡢᐃ㔞໬ࢆ⾜࠺ࡓࡵ࡟ࠊ

⏕య⤌⧊ᶍᨃヨᩱࡢከ㔜ᩓ஘ගᦂࡽࡂィ
Flight(TOF)ィ

࡜Time-of-࡜ࢆྠ᫬࡟ ᐃࡍࡿࢩࢫࢸ࣒ࢆᵓ⠏ࡋࠊゎᯒࢆ⾜ࡗࡓࠋ

1) G.Nishimura “Design of a full photon-timing recorder down to 1ns resolution for fluorescence fluctuation measurements”, Review of
Scientific Instruments, 86 : 106108 (2015)1.6⏕య⤌⧊࡟ධᑕࡋࡓගࡣࠊ
⤌⧊ࡢᙉ࠸ᩓ஘ࡢᙳ㡪ࢆཷࡅࠊ⤌⧊ෆࢆᣑᩓⓗ࡟㏱㐣ࡍࡿࠋྍᖸ΅ᛶࡢ㧗࠸ගࡀධᑕࡋࡓ
ሙྜࠊ⤌⧊ෆࡢᩓ஘⢏Ꮚࡀືࡁ࡟ࡼࡾࠊගᙉᗘࡀᦂࡽࡄࡓ

U=12.5mm

1.4

CWᩓ஘ࡉࢀࠊࡲࡓᩓ஘ᅇᩘࡣ☜⋡ⓗ࡟ศᕸࡍࡿࠋࡇࡢศᕸࡣග㊰㛗ศᕸ࡟ẚ౛ࡍࡿࡇ࡜࠿ࡽࠊࡶࡋග㊰㛗ศᕸࡀࢃ࠿ࢀ
ࡤࠊᩓ஘యࡢືࡁ㸦ᖹᆒ㸰஌ኚ఩㸧ࢆホ౯ࡍࡿࡇ࡜ࡀ࡛ࡁ

1

ᅗ13

U=12.5mm

104
103

1.2

+pulselaserࡵࠊࡑࡢᦂࡽࡂࢆィ ࡍࡿࡇ࡜࡟ࡼࡾ⤌⧊ࡢືⓗ࡞᝟ሗࢆᚓࡿ஦ࡀ࡛ࡁࡿࠋ㏻ᖖࡢ༢ᩓ஘ࡢ᫬࡜␗࡞ࡾࠊከ㔜࡟ගࡣ

U=25mm

105

0.01

0.1

1
10
Time (Ps)

100 100010

U=25mmIRF

1020࢖ࣥࢺࣛࣜࣆࢵࢻ⁐ᾮࡢගᏊ┦㛵

2

4
6
Time (ns)ᐃ(ᕥ)࡜TOF

8

ᐃ

(ྑ)⤖ᯝ

ࡿࠋ⏕య⤌⧊ࡢሙྜࠊᆒ୍࡜㏆ఝࡋࡓ࡜ࡋ࡚ࡶ⤌⧊ࡢගᏛᐃᩘࡀᮍ▱࡛࠶ࡿࡓࡵࠊྠ᫬࡟ࡑࢀࡽࢆ▱ࡿᚲせࡀ࠶ࡿࠋ㸦17㸧᫬㛫ศゎἲࢆ⏝࠸ࡓࠊ㧗ឤᗘ⺯ගࢱ࣮ࢤࢵࢺ᳨ฟἲ

ࡑࡢࡓࡵගᏛᐃᩘࡣࠊࣆࢥ⛊ࡢ▷ࣃࣝࢫගධᑕ࡟ᑐࡍࡿ᫬

ࡢ㛤Ⓨᐃࡋග㊰㛗ศᕸࢆ┤᥋ᚓࡿࡇ࡜ࡢ࡛ࡁࡿࠊ

ࡇࢀࡲ࡛ࠊගᏊ᳨ฟࢩࢫࢸ࣒࡜ࣃࣝࢫ࣮ࣞࢨ࣮ࢆ⤌ࡳྜ

TOFἲࢆ⏝࠸ࠊࡑࢀ࡜ྠ᫬࡟ᩓ஘ගࡢᦂࡽࡂࢆගᏊ┦㛵ἲ࡛ࢃࡏࡓ㧗࠸᫬㛫ศゎ⬟ࢆᣢࡘィ ࡟ࡼࡾࠊ῝ࡉ㸯㹡㹫⛬ᗘィ࡟ᇙࡵ㎸ࡲࢀࡓ⺯ගࣉ࣮ࣟࣈ࡟ࡘ࠸࡚ࡢ⏬ീ෌ᵓᡂᡭἲࢆ

㛫ᛂ⟅㛵ᩘࢆ

ࡍࡿࠋ▷ࣃࣝࢫගࡣࠊྍᖸ΅ᛶࡀప࠸ࡓࡵࠊࡑࡢࡲࡲ
ࡍࡿࡢࡣ㞴ࡋ࠸ࡓࡵࠊྍᖸ΅ᛶ◊✲ࡋ࡚ࡁࡓࠋࡋ࠿ࡋ⏬ീ෌ᵓᡂ࡟ࡣከ኱࡞ィ⟬᫬㛫ࢆせࡢ㧗࠸༢୍⦪࣮ࣔࢻ࣮ࣞࢨ࣮ࡢගࢆྠ᫬࡟ධᑕࡋࠊ඲ࡃྠ

ࡍࡿ࡞࡝ᐇ⏝࡟⮳ࡿ࡟ࡣࠊㄢ㢟ࡀከ࠸ࠋࡋ࠿ࡋࠊᐇ㝿ࡢ་ࡌගᏛ⣔࡛ྠ᫬࡟୧⪅ࢆ⒪⌧ሙ࡛ࡣࠊࡑࡢᏑᅾ࡜ᐃᛶⓗ࡞఩⨨࡟㛵ࡍࡿ᝟ሗࡔࡅ࡛

࡛ࡣᩓ஘ගࡢᦂࡽࡂࢆィᐃ࡛ࡁࡿࡼ࠺࡟ࢩࢫࢸ࣒ࢆᵓ⠏ࡋࡓࠋࡲࡓࠊ㧗㏿࡟ගᏊ┦㛵ࢆィࡍࡿࡓࡵࢹࣂ࢖ࢫࡶ᪂

ࡶᐇ⏝࡟࡞ࡿྍ⬟ᛶࡀ࠶ࡾࠊࡑࡢ᪉ἲࢆ⪃ᐹࡋࡓࠋ⺯ගయࡀ⤌⧊࡞࡝࡟ᇙࡵ㎸ࡲࢀ࡚࠸ࡿሙྜࠊ᳨ฟ㝈⏺ࡣつ࡟ヨసࡋࡓࠋ
⤌⧊ᶍᨃヨᩱ࡜ࡋ࡚⬡㉁⢏Ꮚ(࢖ࣥࢺࣛࣜࣆࢵࢻ)ࡢᠱ⃮⫼ᬒග࡟ࡼࡾそ࠸㞃ࡉࢀࡿࡇ࡜࡟ࡼࡿࠋ≉࡟ᙉ࠸ᩓ஘య࡛

ᐃ࡜TOF ᐃࢆ⾜ࡗࡓࠋᅗ13࡟ࡑ࠶ࡿሙྜࠊ⺯ගయࡢീࡀⴭࡋࡃᗈࡀࡿࡇ࡜࡜ࠊ፹㉁ࡢ྾཰

ࡢ⤖ᯝࢆ♧ࡋࡓࠋᅗ13(ᕥ)ࡣගᏊ┦㛵㛵ᩘࢆ♧ࡋࠊධᑕ᳨

࡟ࡼࡿᙉᗘࡢῶ⾶ࡀ┦ࡲࡗ࡚ࠊ⫼ᬒග࡟ᇙࡶࢀ᫆ࡃ࡞ࡗ࡚

ฟ㛫㊥㞳 Ȩ ࢆኚ࠼ࠊࡲࡓ༢୍⦪࣮ࣔࢻ(CW)࣮ࣞࢨ࣮ࡢࡳ

࠸ࡿࠋࡑࡢࡓࡵࠊ⫼ᬒග࡜⺯ගయ⏤᮶ࡢ⺯ග࡜ࢆ༊ูࡋ࡚

ᾮࢆ⏝࠸ࡑࡇ࡛ගᏊ┦㛵ᐃࡍࡿࡇ࡜࡟ࡼࡾࠊࡼࡾ⺯ගయࡢ᳨ฟ⬟ࢆୖࡆࡿࡇ࡜ࡀ

࡛ࡁࡿࠋ⺯ගࣉ࣮ࣟࣈ࡟⏝࠸ࡿⰍ⣲ࡣ⮫ᗋ࡟౑⏝ྍ⬟࡞࢖

Shielding of Rapidly Growing Cells Buffers Growth Het-ࣥࢻࢩ࢔ࢽࣥࢢ࣮ࣜࣥ(ICG)࡟㝈ࡽࢀࡿࡓࡵࠊࡑࡢไ㝈ࡢࡶ

erogeneity and Contributes to Organ Shape Reproduci-࡜࡟ࠊ᫬㛫ᛂ⟅ࡢ㐪࠸࠿ࡽ༊ูࡍࡿ᪉ἲࢆ☜࠿ࡵࡓࠋᅗ14

bility”, Current Biology, 27(22): 3468–3479 (2017)࡟ࡣ㣗⫗ࢆࣄࢺ⤌⧊࡜ぢ❧࡚ࡓࣇ࢓ࣥࢺ࣒ࢆ⏝࠸ࠊICGࢆ䠐䠅J. Alfermann, X. Sun, F. Mayerthaler, T. E. Morrell, E.

ྵࡴ⺯ගయࢆᇙࡵ㎸ࡳࡑࡢ⺯ගࡢບ㉳ගࣃࣝࢫ࡟ᑐࡍࡿ᫬

Dehling, G. Volkmann, T. Komatsuzaki, H. Yang and H.

㛫ᛂ⟅㛵ᩘࢆ

ᐃࡋࡓࠋ⫼ᬒගࡢ᫬㛫ᛂ⟅ࡣ⺯ගయࡢࡑࢀ

D. Mootz: “FRET monitoring of a nonribosomal peptideࡼࡾࡶ㏿ࡃࠊࡑࡢ㐪࠸ࡣ2ns௜㏆࡛᭱኱࡛࠶ࡗࡓᅗ14(a)ࠋࡑ

synthetase”, Nature Chemical Biology, 13: 1009–1015ࡢ᫬㛫㡿ᇦࡢᙉᗘࢆ⏝࠸࡚⺯ගീࢆసࡗࡓࡶࡢ࡜(gated)ࠊ

(2017)

ᐃᖖග࡛ᚓࡽࢀࡿ࡛࠶ࢁ࠺⺯ගീ (total)ࢆẚ㍑ࡋࡓ (ᅗ䠑䠅

H. Teramoto, K. Kondo, S. Izumiya, M. Toda and T. Ko-

14(b))ࠋ⫼ᬒගࡀ୺య࡜࡞ࡿ㎶⦕㒊࡛ࡢᙉᗘࡀ᫬㛫㡿ᇦࢆ㑅

matsuzaki: “Classification of Hamiltonians in neighbor-ࡪࡇ࡜࡟ࡼࡾୗࡀࡾࠊࢥࣥࢺࣛࢫࢺࡀୖ᪼ࡋ࡚࠸ࡿࡇ࡜ࡀ

hoods of band crossings in terms of the theory of singu-ࢃ࠿ࡿࠋ⫼ᬒග࡜⺯ග࡜ᙉᗘẚࢆࢥࣥࢺࣛࢫࢺ࡜ᐃ⩏ࡋࠊ

larities”, Journal of Mathematical Physics, 58: 073502-1–

ࡑࢀࢆ♧ࡋࡓࡢࡀᅗ14(c)࡛࠶ࡿࠋࢥࣥࢺࣛࢫࢺࡣ⣙㸳ಸᨵၿࡋࡓࠋࡇࢀࡣ⏕య⤌⧊࡟ᇙࡵ㎸ࡲࢀࡓ⺯ගయ࡟ࡘ࠸࡚ࡼ

073502-39 (2017)
䠒䠅

K.Prieto, and G.Nishimura, “A new scheme of the time-ࡾ㧗ឤᗘ࡟᳨ฟྍ⬟࡛࠶ࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋ௒ᚋࠊࢭࣥ

domain fluorescence tomography for a semi-infinite turbidࢳࢿࣝࣜࣥࣃ⠇ࡢ᳨ฟ࡞࡝ࡢᐇ㝿ࡢࣄࢺ࡬ࡢᛂ⏝࡬࡜㐍ࡵmedium.” Opt.Rev. 24, 242-251, (2017)
䠓䠅ࡿࠋ

K.Prieto, and G.Nishimura, “A novel approach for the1) すᮧ ࿃ᮁ㸸≉㢪2017-181583ࠊ
ࠕ⏕య᳨ᰝ⿦⨨ཬࡧ⏕య᳨ᰝ

time-domain fluorescence imaging of a semi-inifinite tur-᪉ἲࠖࠊ2017.9.21.

bid medium: Monte Carlo evaluation.” SPIE Proc., 10059,

10 5

total

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ducible organ development through spatiotemporal averaging”, Developmental Cell, 38(1) : 15-32 (2016)

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-10
-15 -10 -505mant, R. S. Smith, T. Komatsuzaki, C. Li, A. Boudaoud1
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L. Hong, M. Dumond, S. Tsugawa, A. Sapala, A. RoutierKierzkowska, Y. Zhou, C. Chen, A. Kiss, M. Zhu, O. Ha-

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䠕䠅

S. Tsugawa, H. Nathan, O. Hamant, A. Boudaoud, R. S.
Smith, C. Li and T. Komatsuzaki : “Extracting subcellular
fibrillar alignment with error estimation: Application to20 25

ᅗ 14㸸⺯ගయࢆᇙࡵ㎸ࡲࢀࡓࣇ࢓ࣥࢺ࣒࡛ࡢ᫬㛫ᛂ⟅㛵ᩘ(a)࡜ࡑࢀࢆ⏝࠸࡚ᚓࡽࢀࡓ⺯ගീ(b)ࠋࡲࡓ⺯ගീࡢ\ PP ࡛ࡢࢥࣥࢺࣛࢫࢺࡢࣉࣟࣇ࢓࢖ࣝ(c)ࠋ

microtubules”, Biophysical Journal, 110(8) : 1836-1844(2016)
䠍䠌䠅 G.Nishimura, K.Awasthi, and D.Furukawa, “Fluorescence
lifetime measurements I heterogeneous scattering medium,” J.Biomed.Opt. 21, 075013≗≑᝻૰‒(2016).

䠍䠍䠅 C. Li, H. Ueno, R. Watanabe, H. Noji and T.
.RPDWVX]DNL͆$73K\GURO\VLVDVVLVWVSKRVSKDWH

4.1 Ꮫ⾡ㄽᩥ㸦ᰝㄞ࠶ࡾ㸧

release and promotes reaction ordering in F1-

䠍䠅J. N. Taylor, M. Pirchi, G. Haran and T. Komatsuzaki:$73DVH͇1DWXUH&RPPXQLFDWLRQV  -9

“Deciphering hierarchical features in the energy land-(2015)

䠎䠅scape of adenylate kinase folding/unfolding”, J. Chem.

䠍䠎䠅 Y. Nagahata, S. Maeda, H. Teramoto, T. Horiyama,

Phys. Special Issue on Single Molecule Biophysics, 148:77DNHWVXJXDQG7.RPDWVX]DNL͆'HFLSKHULQJ

123325-1–123325-14 (2018)(invited)

7LPH 6FDOH +LHUDUFK\ LQ 5HDFWLRQ 1HWZRUNV ͇

Y. Tamiya, R. Watanabe, H. Noji, C. Li and T. Komatsu-

The Journal of Physical Chemistry B, 120, 1961

zaki: “Effects of non-equilibrium angle fluctuation on F1-

䠏䠅Ѹ1971(2016)(invited)

ATPase kinetics induced by temperature increase”,

䠍䠏䠅 Y. Sumiya, Y. Nagahata, T. Komatsuzaki, T.

Physical Chemistry Chemical Physics, 3(20): 1872–1880

7DNHWVX DQG 6 0DHGD  ͆.LQHWLF $QDO\VLV IRU(2017)

the Multistep Profiles of Organic Reactions:N. Hervieux, S. Tsugawa, A. Fruleux, M. Dumond, A.

Significance of the Conformational Entropy on

Routier-Kierzkowska, T. Komatsuzaki, A. Boudaoud, J.
C. Larkin, R. S. Smith, C. Li and O. Hamant: “Mechanicalthe Rate Constants of the Claisen Rearrange-㸷)ᑎᮏ ኸࠊᡞ⏣ ᖿேࠊἙ㔝 ⿱ᙪࠊ㧘ᶫ ṇᙪࠊᑠᯇᓮ

PHQW ͇ 7KH -RXUQDO RI 3K\VLFDO &Kemistry A,Ẹᶞ : ࠕ໬Ꮫ཯ᛂࡢ⾜ࡁඛࢆኚ࠼ࡿ“ࢫ࢖ࢵࢳ䇿䒾࢚

119(49) : 11641-11649 (2015)ࢿࣝࢠ࣮ࡢୖ࡛᪼཯ᛂ⤒㊰ࡀษࡾ᭰ࢃࡿ᪂⌧㇟ࠖࠊ᭶
ห໬Ꮫࠊ71(5) : 25-30 (2016)

䠍䠐䠅 *1LVKLPXUD͆'HVLJQRIDIXOOSKRWRQ-timing recorder down to 1-ns resolution for fluorescence㸯㸮) すᮧ

࿃ᮁ͇⏕య⤌⧊࢖࣓࣮ࢪࣥࢢ⺯ග⏬ീ෌ᵓIOXFWXDWLRQPHDVXUHPHQWV͇5HYLHZRI6FLHQWLILF

ᡂࡢࡑࡢ᪉ἲ࡜ㄢ㢟͇ ග࢔ࣛ࢖࢔ࣥࢫ 27:6-11

Instruments, 86 : 106108 (2015)(2016).

䠍䠑䠅 H. Teramoto, M. Toda, M. Takahashi, H. Kono and
7.RPDWVX]DNL͆0HFKDQLVPDQG([SHULPHQWDO2E

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servability of Global Switching Between Reactive㸯)

M. Tavakoli, J. N. Taylor, C.-B. Li, T. Komatsuzaki andand Nonreactive Coordinates at High Total Ener-S. Pressé : “Single Molecule Data Analysis: An Introduc-

JLHV͇ 3K\VLFDO 5HYLHZ /HWWHUs, 115(093003)

tion” Advances in Chemical Physics”, John Wiley & Sons
Inc. 162, 205-306 (2017)(2015)
䠍䠒䠅 H.

Teramoto,

M.

Toda

and

T.

Komatsuzaki:㸰)Ọ஭ ೺἞ࠊ෠ᶔ ♸୍㸦⦅㸧ࠊᑠᯇᓮ Ẹᶞ㸦ⴭ㸧 : ࠕᑡ

͆%UHDNGRZQ PHFKDQisms of normally hyperbolicᩘᛶ⏕≀Ꮫ㸸➨ 5 ❶ࠕᑡᩘࡢಶᛶ㹼ศᏊ࡟ࡶಶᛶ㸽invariant manifolds in terms of unstable peri-㹼ࠖࠖࠊᰴᘧ఍♫᪥ᮏホㄽ♫ (2017)

odic orbits and homoclinic/heteroclinic orbits
LQ+DPLOWRQLDQV\VWHPV͇1RQOLQHDULW\  

4.5 ㅮ₇(2015)

㹟㸬ᣍᚅㅮ₇㸦ᅜ㝿Ꮫ఍㸧㸯)S. Ito* : “Stochastic thermodynamics of information”,

4.2 Ꮫ⾡ㄽᩥ㸦ᰝㄞ࡞ࡋ㸧

Frontiers of complex systems science: soft matter, bio-ヱᙜ࡞ࡋ

physics, and statistical physics, Institute of Physics Auditorium, Academia Sinica, Taipei, Taiwan (2018-01).

4.3 ⥲ㄝ࣭ゎㄝ࣭ホㄽ➼
䠍)
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ᑠᯇᓮ Ẹᶞ:໬Ꮫ཯ᛂ⌮ㄽ䛾ᬑ㐢ᛶ䠖GRRM 䛻ᮇ䛩䜛

scape from single molecule time series under the exist-

䜒䛾䚸IQCE NEWS No.57, 1(2018).

ence of noise?”, The 2nd Korea-Japan Joint Symposiumすᮧ ࿃ᮁ : ࠕ⤌⧊➼ᩓ஘యෆ㒊࡟ྵࡲࢀࡿ⺯ග≀㉁

on Single-Molecule Biophysics, Seoul National University,
Korea (2017-11)ࡢ㧗ឤᗘ᳨ฟᢏ⾡ࠖࠊࢣ࣑࢚࢝ࣝࣥࢪࢽ࢔ࣜࣥࢢࠊ㸴
㸱(㸰) :165-170 (2018).
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gle molecule FRET time series : Role of Photobleaching”,⏕≀Ꮫࡗ࡚࡞ࢇࡔ㸽: ࠕᑡᩘ࡜ಶᛶ䇷ศᏊࡢᩘ࡜⏕࿨Deciphering complex energy landscape and kinetic net-ࡽࡋࡉࠖࠖࠊᐇ㦂་Ꮫࠊ35(19): 3190-3196 (2017)

work from single molecules to cells: a new challenge toఀ⸨๰♸㸪Ἃᕝ㈗኱: ࠕࢿࢵࢺ࣮࣡ࢡୖࡢ᝟ሗ⇕ຊᏛmake theories meet experiments, Hotel Mercure Dijon,

72(9):658 (2017)

䠒)France (2017-09)
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signaling networks”, Deciphering complex energy land-ຊᏛ࡜ࡑࡢ⏕య᝟ሗฎ⌮࡬ࡢᛂ⏝㸦➨ 62 ᅇ≀ᛶⱝᡭ

scape and kinetic network from single molecules to cells:ኟࡢᏛᰯ 㞟୰ࢮ࣑㸧ࠖࠊ≀ᛶ◊✲ࠊ6(4):064232 (2017)a new challenge to make theories meet experiments, Ho-すᮧ ࿃ᮁ : ࠕ㏆㉥እ⏕యศග࡟㛵ࡍࡿ᭱᪂ᢏ⾡ࠖࠊtel Mercure Dijon, France (2017-09)
㸳)

G.Nishimura*, “Near-infrared fluorescence detection and

L. Wiesenfeld, W. Thi, P. Caselli, A. Faure, L. Bizzocchi,

its medical applications,” The 10th ICME International

J. Brandão, D. Duflot, E. Herbst, S. J. Klippenstein, T.

Conference on Complex Medical Engneering (CME2016),

Komatsuzaki, C. Puzzarini, O. Oncero, H. Teramoto, M.

Tochigi Prefecture Culture Center Utsunomiya, Japan(2016.8.4-6)

Toda, A. Avoird and H. Waalkens :ࠕTheory of Gas Phase
Scattering and Reactivity for AstrochemistryࠖࠊReport㸶)S. Ito* : “Thermodynamics of information on biochemicalఀ⸨๰♸: ࠕࠓㅮ⩏ࣀ࣮ࢺࠔࢿࢵࢺ࣮࣡ࢡୖࡢ᝟ሗ⇕ග࢔ࣛ࢖࢔ࣥࢫ ࠊ28(6): 7-10 (2017).
㸵)

T. Komatsuzaki* : “Energy landscapes learned from sin-෠ᶔ ♸୍ࠊ᪂ᾏ ๰ஓࠊᑠᯇᓮ Ẹᶞ: ࠕ≉㞟㸸ᑡᩘᛶ࡜ࡑࡢ⏕య᝟ሗฎ⌮࡬ࡢᛂ⏝ࠖࠊ᪥ᮏ≀⌮Ꮫ఍ㄅࠊ䠑)

T. Komatsuzaki* : “How one can extract energy land-㸴)

T. Komatsuzaki* : “Global Transition States in Reaction

from the Workshop on Theory of Gas Phase Scattering

Network”, Telluride Workshop on Chemistry & Dynamics

and Reactivity for Astrochemistry Nov 23 – Dec 4, 2015ࠊ

in Complex Environments, Telluride Elementary School,

1-24 (2016)

United States of America (2017-06)

ᑠᯇᓮ Ẹᶞ : ࠕࢹ࣮ࢱ⛉Ꮫ㞧ឤࠖࠊ⏕≀≀⌮ࠊ54(4) :197 (2016)

㸵)

T. Komatsuzaki* : “Data-driven mathematics in single

cell Raman imaging”, Telluride Workshop on The Complexity of Dynamics and Kinetics from Single Molecules toࣕࣥࣃࢫ(2018-03)
䠏䠅Cells, Telluride Elementary School, United States of࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿᑡᩘᛶࡢ⏕࿨⛉Ꮫࠖࠊ2017 ᖺᗘ⏕࿨⛉Ꮫ⣔ᏛAmerica (2017-06)㸶)ᑠᯇᓮ Ẹᶞ* : ࠕ୍⣽⬊࣐ࣛࣥィ఍ྜྠᖺḟ኱఍ࠊ⚄ᡞᅜ㝿఍㆟ሙ(2017-12)

T. Komatsuzaki* : “A kinetic disconnectivity graph to䠐䠅

decode timescale hierarchy buried in reaction networks”,
Conference on Energy Landscapes: Theory and Applica-ไᚚ㐃ྜㅮ₇఍ࠊ㟁Ẽ㏻ಙ኱Ꮫ(2017-11)䠑䠅ᑠᯇᓮ Ẹᶞ* : ࠕHow can one quantify singularity incells from Single Cell Raman Imaging?ࠖࠊ➨ 55 ᅇ᪥ᮏ⏕tions, The Centre IGESA, France (2016-06 ࠥ 2016-07)≀≀⌮Ꮫ఍ᖺ఍ࠊ⇃ᮏ኱Ꮫ㯮㧥໭ᆅ༊(2017-09)㸷) &/L ͆)URPVLQJOHPROHFXOHWLPHVHULHVWR
networks and dynamics: approaches from infor-ఀ⸨ ๰♸* : ࠕ⏕໬Ꮫ⣔ࡢ᝟ሗ⇕ຊᏛࠖࠊ➨ 60 ᅇ⮬ື䠒䠅ఀ⸨ ๰♸*, ten Wolde Pieter rein: ࠕInformation ther-PDWLRQWKHRU\͇&RQIHUHQFHRQWKH7LPHLQ%LR

mos dynamic study of biochemical clockࠖࠊ➨ 55 ᅇ᪥

logical Systems and Beyond, National Tsing Huaᮏ⏕≀≀⌮Ꮫ఍ᖺ఍ࠊ⇃ᮏ኱Ꮫ㯮㧥໭ᆅ༊ (2017-9)

University, Hsinchu, Taiwan (2016-03)

䠓䠅ࣥࣃࢫࠊJapan (2017-7).

͆&ODVVLILFDWLRQRI(OHFWURQ(QHUJ\/HYHO&URVV
ings in terms of the Theory of Singularities andఀ⸨ ๰♸* : ࠕ⏕య㐺ᛂࢭࣥࢧ࣮ࡢ᝟ሗ⇕ຊᏛࠖࠊ᪥
ᮏ⚄⤒ᅇ㊰Ꮫ఍ ᫬㝈◊✲఍ 2017ࠊி㒔኱Ꮫྜྷ⏣࢟ࣕ㸯㸮)H. Teramoto*, M. Toda and T. Komatsuzaki :䠔䠅ᑠᯇᓮ Ẹᶞ* : ࠕ୍⣽⬊࣐ࣛࣥィ࡜᝟ሗ⛉Ꮫࡢ⼥

Analysis of Non-Adiabatic Transitions around theྜ࡟ࡼࡿ⣽⬊デ᩿ࠖࠊ2017 ᖺᗘேᕤ▱⬟Ꮫ఍඲ᅜ኱఍ࠊ

&URVVLQJV͇ &RPSXWDWLRQDO &KHPLVWU\ &&  6\P࢘࢖ࣥࢡ࠶࠸ࡕ(2017-05)

posium in ICCMSE, Metropolitan Hotel, Greece䠕䠅

すᮧ

࿃ᮁ*:ࠕTime-domain fluorescence diffuse optical

tomography for quantitative imaging of a fluorescence tar-

(2016-03)㸯㸯)7.RPDWVX]DNL ͆7RZDUGGHFLSKHULQJFHOOLQ

get in deep biological tissueࠖ➨ 94 ᅇ᪥ᮏ⏕⌮Ꮫ఍኱GLYLGXDOLW\LQV\VWHPVELRORJ\͇6\PSRVLXP

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(2017.3.28-30).

Life at Small Copy Numbers (The 2015 International Chemical Congress of Pacific Basin Soci-䠍䠌䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ࣐࢖ࣀࣜࢸ࢕⣽⬊ࢆ᙮ࡾࡔࡍࢹ࣮
ࢱ⛉Ꮫࠖࠊ➨ 39 ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍ࠊࣃࢩࣇ࢕ࢥ

eties), Sheraton Waikiki, Hawaii, USA (2015-12)

ᶓ὾ (2016-11 ࠥ 2016-12)㸯㸰)7.RPDWVX]DNL ͆(QHUJ\ODQGVFDSHVDQGFRQ
formation network learned from single molecule䠍䠍䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ1 ⣽⬊࣐ࣛࣥศග࢖࣓࣮ࢪࣥࢢ࠿ࡽ

WLPHVHULHV͇6\PSRVLXP'HFLSKHULQJPROHF

ዴఱ࡟ࡋ࡚⣽⬊ࡢಶᛶࢆᐃ㔞໬ࡍࡿ࠿㸽ࠖࠊ➨ 5㸲ᅇular complexity from protein functions to cel-᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍ࠊࡘࡃࡤᅜ㝿఍㆟ሙ (2016-11)

lular network (The 2015 International Chemical
Congress of Pacific Basin Societies), Convention㹡㸬୍⯡ㅮ₇㸦ᅜ㝿Ꮫ఍㸧Center, Hawaii, USA (2015-12)

䠍䠅T.Suzuki, R. Saito, N.Kitada, T.Koike, S.Maki, Y.Michi-㸯㸱)ᑠᯇᓮ Ẹᶞ* : ࠕSingle Molecule Biophysics: How

waki, G.Nishimura, H.Niwa and Y.Yamada, “Aspiration

can One Dig the Underlying Network from Noisy

Risk Detection Using Oral Administration of Fluorescentand Short Time Series?ࠖࠊInternational Conference

Food -- Preliminary Experiments Using Meat Phantoms”,

RQ͆&KDOOHQJHVLQ'DWD6FLHQFHD&RPSOH[6\V

2017 IEEE International Conference on Cyborg and Bi-

tems Perspective"ࠊTorinoࠊItaly (2015-10)

onic Systems (CBS 2017, Oct.17-Oct.19, Science Parkof Beijing Institute of Technology, Beijing, China).

㸯㸲) *1LVKLPXUD͆'LIIXVH2SWLFDO7RPRJUDSK\- Actual Problems in Reconstruction with Time-domain

䠎䠅H. Teramoto* : “Application of Singularity Theory to Ma-'DWD͇7KHWK,&0(,QWHUQDWLRQDO&RQIHUHQFHRQ

terial Sciences ”, Geometric and Algebraic Singularity

Complex Medical Engineering (CME2015) , Okayama㼀㼔㼑㼛㼞㼥㻘㻌㻮㾤㼐㼘㼑㼣㼛㻌㻯㼛㼚㼒㼑㼞㼑㼚㼏㼑㻌㻯㼑㼚㼠㼑㼞㻘㻌㻼㼛㼘㼍㼚㼐㻌㻔㻞㻜㻝㻣-09)

Convention Center, Okayama, Japan (2015-06)

䠏䠅

K.Prieto, and G.Nishimura, “A novel approach for thetime-domain fluorescence imaging of a semi-infinite turbid medium: Monte carlo evaluation”, Bios SPIE Photon-㹠㸬ᣍᚅㅮ₇㸦ᅜෆᏛ఍㸧䠍䠅ᑠᯇᓮ Ẹᶞ* : ࠕ୍⣽⬊࣐ࣛࣥィ

ics West, The Moscone Center, San Francisco, CA, USA࡜᝟ሗ⛉Ꮫࡢ㧗(2017.1.28-2.2)

ᗘ⼥ྜ࡟ࡼࡿ᝟ሗィ ᢏ⾡ࠖࠊ2017 ᖺᗘ➨ 2 ᅇࣂ࢖࢜༢ศᏊ◊✲఍ࠊᚚⲔࣀỈ㸿T㹇఍㆟ᐊ(2018-03)
䠎䠅䠐䠅

K.Hattori,

H.Fujii

G.Nishimura,

K.Kobayashiadᑠᯇᓮ Ẹᶞ* : ࠕ1 ⣽⬊࣐ࣛࣥศග࢖࣓࣮ࢪࣥࢢ࡜᝟

M.Watanabe, “Quantitative method to determine the op-ሗ⛉Ꮫࡢ interdependent ࡞⼥ྜࢆ┠ᣦࡋ࡚ࠖࠊ➨ 65 ᅇtical properties of melons by the photon diffusion equa-ᛂ⏝≀⌮Ꮫ఍᫓ᏘᏛ⾡ㅮ₇఍ࠊ᪩✄⏣኱Ꮫす᪩✄⏣࢟tion”, Asian NIR Symposium 2016 (ANS2016), Shiroyama

Kanko Hotel, Kagoshima, Japan (2016.11.30-12.3)
䠑䠅

H.Fujii,

G.Nishimura,

K.Hattori,

K.Kobayashi

Resort, USA (2015-05)
and䠍䠏䠅 *1LVKLPXUD͆1HDU-infrared fluorescence fluc-

M.Watanabe, “Near-infrared optical properties of whitetuation measurement system - Its design and ap-

bread using the light propagation model,” Asian NIR Sym-

SOLFDWLRQV͇Wh Asian and Pacific Rim Sympo-

posium 2016 (ANS2016), Shiroyama Kanko Hotel, Kago-sium on Biophotonics (APBP`15),

shima, Japan (2016.11.30-12.3)
䠒䠅

K.Hattori,

H.Fujii,䠓䠅hama, Yokohama, Japan (2015-04).
and䠍䠐䠅 ')XUXNDZDDQG*1LVKLPXUD͆6WXG\RQDUHFRQ

M.Watanabe, “Optical properties of melons determinedstuction technique using time domain reflectanceby an analysis based on the photon diffusion equation,”

PHDVXUHPHQWVGDWD͇WK$VLDQDQG3DFLILF5LP

Furst Fiid Chemistry Conference – Shaping the Guture of

Symposium on Biophotonics (APBP`15),

Food Quality, Health and Safety, NH Grand Hotel

Yokohama, Yokohama, Japan (2015-04)

Kransnapolsky,

G.Nishimura,

Amsterdam,

K.Kobayashi

The(2016.10.30-11.1)

㹢. ୍⯡ㅮ₇㸦ᅜෆᏛ఍㸧

K.Prieto and G.Nishimura, “A new strategy of the time-䠍䠅すᮧ࿃ᮁ,ࠕ⏕య⤌⧊୰࡟࠶ࡿ⺯ගࢱ࣮ࢤࢵࢺࡢ㧗

domain fluorescence imaging for a semi-infinite turbidឤᗘ᳨ฟࠖ,Optics and Photonics Japan 2017, (2017)

media,” 2nd Biomedical Imaging and Sensing Conference

10.30-11.2 (⟃Ἴ኱Ꮫᮾி࢟ࣕࣥࣃࢫᩥிᰯ⯋ࠊᩥி

(2016.5.18-20).

༊)䠎䠅ᑎᮏ ኸ*ࠊἨᒇ ࿘୍ࠊᑠᯇᓮ Ẹᶞ : ࠕ᩿⇕࢚ࢿࣝࢠJ. N. Taylor*, A. F. Palonpon, C. Li, K. Fujita࣮㠃஺ᕪ㏆ഐ࡛ࡢࣁ࣑ࣝࢺࢽ࢔ࣥࡢ≉␗Ⅼㄽ࡟ࡼࡿ

DQG 7.RPDWVX]DNL ͆'DWD-driven quantifica-ศ㢮ࠖࠊ᪥ᮏ≀⌮Ꮫ఍ 2017 ᖺ⛅Ꮨ኱఍ࠊᒾᡭ኱Ꮫ ୖtion of heterogeneous microenvironments in liveFHOO5DPDQPLFURVFRSLFLPDJHV͇7KH%LRSK\VLFDO䠕䠅Pacifico

Netherlands

2016 (BISC2016), Pacifico Yokohama, Yokohama, Japan䠔䠅

Pacifico Yoko-⏣࢟ࣕࣥࣃࢫ(2017-09)
䠏䠅

K. M. Helal*, H. Cahyadi, J. N. Taylor, A. Okajima, Y.

Society 2016 BPS Annual Meeting, Los Angeles

Kumamoto, H. Tanaka, Y. Harada and T. Komatsuzaki :Convention Center, USA (2016-02)“Information-theoretical data analysis approaches to Ra-

J. N. Taylor*, A. F. Palonpon, C. Li, K. Fujita

man micro-spectroscopic images”, ➨ 11 ᅇศᏊ⛉Ꮫウ

DQG 7.RPDWVX]DNL ͆'DWD-driven quantifica-ㄽ఍, ᮾ໭኱Ꮫ ᕝෆ໭࢟ࣕࣥࣃࢫ(2017-09)

tion of heterogeneous microenvironments in live-䠐䠅ఀ⸨ ๰♸*, P. R. ten Wolde : ࠕ⏕໬Ꮫ᫬ィࡢ᝟ሗ⇕

FHOO5DPDQPLFURVFRSLFLPDJHV͇6\PSRVLXP

ຊᏛࠖࠊ᪥ᮏ≀⌮Ꮫ఍ 2017 ᖺ⛅Ꮨ኱఍ࠊᒾᡭ኱Ꮫୖ⏣Deciphering molecular complexity from protein࢟ࣕࣥࣃࢫ(2017-09)

functions to cellular network (The 2015 Inter-䠑䠅

J. N. Taylor*, K. Fujita and T. Komatsuzaki : “Datanational Chemical Congress of Pacific Basin So-

Driven Approaches to Raman Microscopic Analysis”, ➨cieties), Convention Center, USA (2015-12)

5 㸲 ᅇ᪥ ᮏ⏕≀ ≀⌮ Ꮫ఍ᖺ ఍ , ࡘ ࡃ ࡤᅜ 㝿఍ ㆟ሙ
(2016-11)

䠍䠌䠅 H. Teramoto*, M. Toda, M. Takahashi, H. Kano and
7.RPDWVX]DNL͆$*OREDO'\QDPLFDO6ZLWFKLQJ䠒䠅N. Preetom*, K. Helal, H. Teramoto, N. Yamaguchi, C.

of a Reaction Coordinate and its Experimental

Li, H. Haga and T. Komatsuzaki : “Spatial heterogeneous

2EVHUYDELOLW\͇VW6\mposium on Chemical Ki-

and transient dynamics during collective cell migration in

netics and Dynamics, Frontier Research in Ap-

a monolayer of MDCK epithelial cells”, ➨ 5㸲ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ᖺ఍, ࡘࡃࡤᅜ㝿఍㆟ሙ (2016-11)

plied Sciences Bldg., Faculty of Engineering,
Hokkaido University (2015-06)

䠓䠅

K.Prieto, すᮧ ࿃ᮁ*ࠊࠕ཯ᑕᆺᣑᩓ⺯ගࢺࣔࢢࣛࣇ࢕

䠍䠍䠅 Y. Nagahata*, S. Maeda, H. Teramoto, C. Li, T.

- ༙↓㝈፹య୰ࡢ⺯ගࢱ࣮ࢤࢵࢺ࢖࣓࣮ࢪࣥࢢࠖࠊ

Horiyama, T. Taketsugu and T. Komatsuzaki :Optics and Photonics Japan 2016ࠊ⟃Ἴ኱Ꮫᮾி࢟ࣕࣥ
ࣃࢫᩥிᰯ⯋ࠊ(2016.10.30-11.2).

͆'HFLSKHULQJ WLPHVFDOH hierarchy encoded in
FRPSOH[UHDFWLRQ QHWZRUNV͇ VW6\PSRVLXP RQ䠔䠅Ọᖭ ⿱ࠊ๓⏣ ⌮ࠊᑎᮏ ኸࠊṊḟ ᚭஓࠊᑠᯇᓮ Ẹ

Chemical Kinetics and Dynamics, Frontier Re-

ᶞ* : ࠕ᫬㛫ゎീᗘ࡟౫Ꮡࡋࡓ཯ᛂࢿࢵࢺ࣮࣡ࢡࡢ㝵search in Applied Sciences Bldg., Faculty of En-

ᒙⓗኚ໬࡜ࡑࡢண

2016ࠊ⚄ᡞࣇ࢓ࢵࢩ࣐࣮ࣙࣥࢺ (2016-09)

gineering, Hokkaido University (2015-06)
䠍䠎䠅 7.RPDWVX]DNL 07RGDDQG+7HUDPRWR͆$ᡭἲࡢ㛤ⓎࠖࠊศᏊ⛉Ꮫウㄽ఍

䠕䠅

ྂᕝ

኱௓ࠊすᮧ

࿃ᮁ:ࠕ᫬㛫้ࡳ⿵ṇ࡟ࡼࡿ㸱ḟ

Dynamical Switching of Reactive and Nonreactiveඖᣑᩓࢺࣔࢢࣛࣇ࢕࣮ἲࡢ㧗㏿໬ࠖ᪥ᮏගᏛ఍ᖺḟᏛ

0RGHVDW+LJK(QHUJLHV͇6,$0&RQIHUHQFH

⾡ㅮ₇఍(OPJ2015)ࠊ⟃Ἴ኱Ꮫᮾிᩥிᰯ⯋ࠊᩥி༊ࠊ

on Dynamical Systems, Snowbird Ski and Summerᮾி㒔(2015.10)

䠍䠌䠅 すᮧ࿃ᮁ:ࠕᣑᩓᖸ΅ィ࡜᫬㛫ศゎィ

ࡢྠ᫬

analysis”, 2017 ᖺᗘ᪥ᮏ⏕≀≀⌮Ꮫ఍໭ᾏ㐨ᨭ㒊౛఍,ᐃ࡟ࡼࡿᩓ஘యືែゎᯒࠖ᪥ᮏගᏛ఍ᖺḟᏛ⾡ㅮ₇఍
(OPJ2015)ࠊ⟃Ἴ኱Ꮫᮾிᩥிᰯ⯋ࠊᩥி༊ࠊᮾி㒔໭ᾏ㐨኱Ꮫ⌮Ꮫ㒊 5 ྕ㤋, Japan (2018-03)
䠏䠅(2015.10)⏣⏿ බḟ*ࠊ୰ᮧ ⠜⚈ࠊᮏከ ῟ஓࠊᑠᯇᓮ Ẹᶞ :
ࠕヨ⾜ᅇᩘࡢᑡ࡞࠸ᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝࢦࣜࢬ࣒ࠖ
ࠊ䠍䠍䠅 Ọᖭ ⿱*ࠊ๓⏣ ⌮ࠊᑎᮏ ኸࠊᮤ ᣺㢼ࠊᇼᒣ ㈗ྐࠊ

ேᕤ▱⬟Ꮫ఍➨ 106 ᅇேᕤ▱⬟ᇶᮏၥ㢟◊✲఍ࠊᣦᐟṊḟ ᚭஓࠊᑠᯇᓮ Ẹᶞ : ࠕ」㞧ศᏊ⣔ࡢ␗ᛶ໬཯
ᛂࢿࢵࢺ࣮࣡ࢡ࡟ᇙࡵ㎸ࡲࢀࡓ᫬㛫㝵ᒙᵓ㐀ࡢゎㄞࠖࠊᕷẸ఍㤋ࠊJapan (2018-03)䠐䠅➨9ᅇศᏊ໬Ꮫウㄽ఍ࠊᮾிᕤᴗ኱Ꮫ ኱ᒸᒣ࢟ࣕࣥࣃఀ⸨ ๰♸* : ࠕStochastic Thermodynamic Interpretationof Information Geometryࠖࠊⱝᡭ◊✲఍ࠕ⤫ィ≀⌮Ꮫ࡜ࢫ (2015-09)

ࡑࡢ࿘㎶ࠖࠊᮾி኱Ꮫ⌮Ꮫ㒊(2018-03) 㸦ᣍᚅ㸧䠍䠎䠅 ⏣ᐑ ⿱἞*ࠊᮤ ᣺㢼ࠊΏ㑓 ຊஓࠊ㔝ᆅ ༤⾜ࠊᑠᯇ䠑䠅ᑎᮏ ኸ* : ࠕ≉␗Ⅼㄽࡢ≀㉁⛉Ꮫ࡬ࡢᛂ⏝ࠖࠊࡉࡁࡀᓮ Ẹᶞ : ࠕ㠀ᖹ⾮ຠᯝࡀᘬࡁ㉳ࡇࡍF1ศᏊ࣮ࣔࢱ

ࡅࠕᩘᏛ༠ാࠖ➨ 8 ᅇ㡿ᇦ఍㆟ࠊ࣍ࢸࣝࢥࢫࣔࢫࢡ࢚

࣮ࡢ㠀࢔ࣞࢽ࢘ࢫᆺ ᗘ౫Ꮡᛶࠖࠊ➨9ᅇศᏊ໬Ꮫウㄽ࢔ᅜ㝿஺ὶࢭࣥࢱ࣮ࠊJapan (2018-02)

఍ࠊᮾிᕤᴗ኱Ꮫ ኱ᒸᒣ࢟ࣕࣥࣃࢫ (2015-09)

䠒䠅

G.Nishimura, “Diffuse Correlation Spectroscopy: Analy-䠍䠏䠅 ⏣ᐑ ⿱἞*ࠊᮤ ᣺㢼ࠊΏ㑓 ຊஓࠊ㔝ᆅ ༤⾜ࠊᑠᯇ

sis of Moving Particles”, Inverse problems and medicalᓮ Ẹᶞ : ࠕ㠀ᖹ⾮ຠᯝࡀᘬࡁ㉳ࡇࡍF1ศᏊ࣮ࣔࢱ

imaging, (Graduate School of Mathematical Science, The࣮ࡢ㠀࢔ࣞࢽ࢘ࢫᆺ

University of Tokyo, 13 Feb.-- 16 Feb., 2018)ᗘ౫Ꮡᛶࠖࠊ➨53ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ࠊ㔠ἑ኱Ꮫゅ㛫࢟ࣕࣥࣃࢫ⮬↛⛉Ꮫᮏ㤋䠓䠅すᮧ࿃ᮁ,ࠕᩓ஘ගࡢ᫬㛫ᛂ⟅㛵ᩘ࡜ධᑕฟᑕࢪ࢜

࣓ࢺࣜࠖࠊ㍺㏦⌮ㄽ࡜⏕య་⏝ගᏛ, (⏘⥲◊⮫ᾏ๪㒔

(2015-09)ᚰࢭࣥࢱ࣮, 1 Feb. 2018).

䠍䠐䠅 ὠᕝ ᬡ*ࠊᮤ ᣺㢼ࠊᑠᯇᓮ Ẹᶞ : ࠕ᳜≀ࡢ୰ࡢᒁᡤᚤᑠ⟶࡜⣽⬊ᡂ㛗ࡢ㛵ಀ࡟ࡘ࠸࡚ࠖࠊ➨53ᅇ᪥ᮏ⏕䠔䠅ఀ⸨ ๰♸* : ࠕ᝟ሗ⇕ຊᏛࡢ㐍ᒎ㸸⣽⬊ෆࢿࢵࢺ࣮࣡

≀≀⌮Ꮫ఍ࠊ㔠ἑ኱Ꮫゅ㛫࢟ࣕࣥࣃࢫ⮬↛⛉Ꮫᮏ㤋ࢡཬࡧ᝟ሗᗄఱ࡬ࡢᣑᙇࠖࠊᮾ໭኱Ꮫᩘ⌮⛉Ꮫ㐃ᦠ◊(2015-09)✲ࢭࣥࢱ࣮࣭࣮࣡ࢡࢩࣙࢵࣉ ⣽⬊ෆࢿࢵࢺ࣮࣡ࢡࡢ
ࢲ࢖ࢼ࣑ࢡࢫ㹼⏕≀Ꮫ࡜ᩘ⌮⛉Ꮫࡢ༠ാ㹼ࠊᮾ໭኱Ꮫ䠍䠑䠅 Ọᖭ ⿱*ࠊ๓⏣ ⌮ࠊᑎᮏ ኸࠊᮤ ᣺㢼ࠊᇼᒣ ㈗ྐࠊ

኱Ꮫ㝔᝟ሗ⛉Ꮫ◊✲⛉(2018-01) 㸦ᣍᚅ㸧Ṋḟ ᚭஓࠊᑠᯇᓮ Ẹᶞ : ࠕ」㞧཯ᛂࢿࢵࢺ࣮࣡ࢡ
࡟ᇙࡵ㎸ࡲࢀࡓ᫬㛫㝵ᒙᵓ㐀ࡢゎㄞࠖࠊ➨53ᅇ᪥ᮏ⏕䠕䠅⏣⏿ බḟ*ࠊ୰ᮧ ⠜⚈ࠊᑠᯇᓮ Ẹᶞ : ࠕከ㝵ᒙࢩࢫ≀≀⌮Ꮫ఍ࠊ㔠ἑ኱Ꮫゅ㛫࢟ࣕࣥࣃࢫ⮬↛⛉Ꮫᮏ㤋ࢸ࣒⏕≀Ꮫ࡟࠾ࡅࡿࢹ࣮ࢱ㥑ື⛉Ꮫࡢᒎ㛤ࠖࠊ໭ᾏ㐨(2015-09)኱Ꮫ㟁Ꮚ⛉Ꮫ◊✲ᡤ ᖹᡂ㸰㸷ᖺᗘ ◊✲஺ὶ఍ࠊ໭࢟

䠍䠒䠅 &/L ͆6LQJOH0ROHFXOH7LPH6HULHV$QDO\VLV
of F1-ATPase to Unravel the Role of Bound-ATP+\GURO\VLV͇➨ 53 ᅇ᪥ᮏ⏕≀≀⌮Ꮫ఍ , 㔠ἑ኱Ꮫゅ㛫࢟ࣕࣥࣃࢫ⮬↛⛉Ꮫᮏ㤋 (2015-09)
䠍䠓䠅 ᑎᮏ ኸ* : ࠕ≉␗Ⅼㄽࢆ⏝ ࠸ࡓ㠀᩿⇕஺ᕪࡢᏳᐃ
ᛶ࡜ศᒱࡢゎᯒࠖࠊ᪥ᮏ≀⌮Ꮫ఍ࠊ㛵す኱Ꮫ (201509)

ࣕࣥࣃࢫ㟁Ꮚ⛉Ꮫ◊✲ᡤ࣭㸯㝵఍㆟ᐊࠊJapan (201801)䠍䠌䠅 ఀ⸨ ๰♸* : ࠕ᝟ሗ⌮ㄽ࡜⇕ຊᏛࠖࠊ໭ᾏ㐨኱Ꮫ㟁Ꮚ⛉Ꮫ◊✲ᡤ ᖹᡂ㸰㸷ᖺᗘ ◊✲஺ὶ఍ࠊ໭࢟ࣕࣥࣃࢫ
㟁Ꮚ⛉Ꮫ◊✲ᡤ࣭㸯㝵఍㆟ᐊࠊJapan (2018-01)䠍䠍䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ໭኱࡜᪥❧ᇶ♏◊ࢭࣥࢱ㐃ᦠ࡟ࡼࡿ᪂ᴫᛕࢥࣥࣆ࣮ࣗࢸ࢕ࣥࢢࡢ⌮ㄽ࡜ᛂ⏝ࠖࠊAIMaP䠍䠔䠅 ᰗ἟ ⚽ᖾ*ࠊἙྜ ಙஅ㍜ࠊ⏣➃ ࿴ோࠊ෠ᒣ ె♸ࠊ␗ศ㔝㐃ᦠࡢࣀ࢘ࣁ࢘ࡢඹ᭷࡜Ỉᖹᒎ㛤ࢆ┠ᣦࡍ࣡ᇉሯ ᙲࠊᑠᯇᓮ Ẹᶞࠊᒸ⏣ ᗣᚿࠊ㔝ᆅ ༤⾜ࠊ௒ᮧ࣮ࢡࢩࣙࢵࣉࠊ᪥ᮏᶫࣛ࢖ࣇࢧ࢖࢚ࣥࢫࣅࣝࢹ࢕ࣥࢢࠊ

༤⮧ : ࠕ୍⣽⬊ィ

Japan (2017-12) 㸦ᣍᚅ㸧࡛ぢ࠼࡚ࡁࡓࣂࢡࢸࣜ࢔⣽⬊ෆATP ⃰ᗘࡢከᵝᛶࠖࠊ➨ 67 ᅇ᪥ᮏ⣽⬊⏕≀Ꮫ఍኱఍ࠊ
ࢱ࣮࣮࣡࣍ࣝ⯪ᇼ (2015-06)

䠍䠎䠅 ᑎᮏ ኸ* : ࠕ⮬↛⌧㇟ࡢ୰࡟₯ࡴ≉␗Ⅼࠖࠊ⍇⍈†≉
␗Ⅼㄽ࣮࣡ࢡࢩࣙࢵࣉࠊࣅ࣮ࣗࣟࢵࢪ⍇⍈ࠊJapan(2017-12) 㸦ᣍᚅ㸧

㹣. ◊✲఍࣭ࢩ࣏ࣥࢪ࣒࣭࣮࢘࣡ࢡࢩࣙࢵࣉ࡞࡝㸦Ꮫ఍௨እ㸧䠍䠅

Molecular Propagation through Degenerated Electron
K. M. Helal*, C. Harsono, J. N. Taylor, A. Okajima, Y.

Energy Level Crossings”, The 18th RIES-Hokudai Inter-

Kumamoto, H. Tanaka, Y. Harada and T. Komatsuzaki :national Symposium, Chateraise Gateaux Kingdom Sap-

“Mulitivariate Data-driven approach to Raman Hyper-

poro, Japan (2017-11 ࠥ 2017-12)

spectral Images to Diagnose Non-alcoholic Fatty Liver䠎䠅䠍䠏䠅 H. Teramoto*, S. Izumiya and T. Komatsuzaki : “Toward䠍䠐䠅 S. Ito* : “Thermodynamics and information geometry”,

Disease(NAFLD)”, 2017 ᖺᗘ᪥ᮏ⏕≀≀⌮Ꮫ఍໭ᾏ㐨Theᨭ㒊౛఍, ໭ᾏ㐨኱Ꮫ⌮Ꮫ㒊 5 ྕ㤋, Japan (2018-03)

Chateraise Gateaux Kingdom Sapporo, Japan (2017-11

S. Sattari* and T. Komatsuzaki : “Understanding cell colony dynamics from images using velocity extraction and

18th

RIES-HokudaiInternational

Symposium,ࠥ 2017-12)
䠍䠑䠅 K. M. Helal*, H. Cahyadi, J. N. Taylor, A. Okajima, Y.

Kumamoto, H. Tanaka, Y. Harada and T. Komatsuzaki :“Raman Microscopic Image Analysis based on Infor-ㄽ࡜ᛂ⏝ࡢ㐃ᦠ᥈⣴ࠊி㒔኱ᏛᩘᏛᩍᐊࠊJapan (201706)

mation-theoretic Approach”, The 18th RIES-Hokudai In-䠎䠓䠅 ᑠᯇᓮ Ẹᶞ* : ࠕከ㝵ᒙࢩࢫࢸ࣒⏕≀Ꮫ࡟࠾ࡅࡿࢹ

ternational Symposium, Chateraise Gateaux Kingdom࣮ࢱ㥑ື⛉Ꮫࡢᒎ㛤ࠖࠊࠕ᪂Ꮫ⾡㡿ᇦ◊✲ࠖࢫࣃ࣮ࢫࣔ

Sapporo, Japan (2017-11 ࠥ 2017-12)ࢹࣜࣥࢢࡢ῝໬࡜㧗ḟඖࢹ࣮ࢱ㥑ື⛉Ꮫࡢ๰ᡂ 2017

䠍䠒䠅 K. Tabata*, A. Nakamura and T. Komatsuzaki : “Bad Arm
Existence Checking Algorithm”, The 18th RIES-HokudaiInternational Symposium, Chateraise Gateaux Kingdom
Sapporo, Japan (2017-11 ࠥ 2017-12)

ᖺᗘ➨ 1 ᅇබ㛤ࢩ࣏ࣥࢪ࣒࢘ࠊᮾி኱Ꮫ Ṋ⏣࣮࣍ࣝࠊJapan (2017-06)
䠎䠔䠅 ᑎᮏ ኸ* : ࠕ≉␗Ⅼㄽ࡟ࡼࡿࣂࣥࢻ஺ᕪ㏆ഐ࡛ࡢࣁ࣑ࣝࢺࢽ࢔ࣥࡢศ㢮ࠖࠊᚤศᗄఱᏛ࡜≉␗Ⅼㄽࡢᛂ⏝ࠊ䠍䠓䠅 J. N. Taylor* and T. Komatsuzaki : “Apparent Nonequi-ᒾᡭ་⛉኱Ꮫ๰❧㸴㸮࿘ᖺグᛕ㤋ࠊJapan (2017-06)

librium Behavior in Single-Molecule FRET Time-Series䠎䠕䠅 ⏣ᐑ ⿱἞*ࠊᑠᯇᓮ Ẹᶞ : ࠕࢱࣥࣃࢡ㉁୍ศᏊࡢ⢓Induced by Photophysics”, The 18th RIES-Hokudai In-ᙎᛶᣲືࢆグ㏙ࡍࡿ᪉⛬ᘧ࡜ෆ㒊ᦶ᧿ࡢ⪃ᐹࠖࠊ⌮◊ternational Symposium, Chateraise Gateaux Kingdomࢩ࣏ࣥࢪ࣒࢘ࠕ⣽⬊ࢩࢫࢸ࣒ࡢືែ࡜ㄽ⌮ IXࠖࠊ⌮໬

Sapporo, Japan (2017-11 ࠥ 2017-12)Ꮫ◊✲ᡤ ⏕≀⛉Ꮫ◊✲ᲷࠊJapan (2017-04)

䠍䠔䠅 ࢫࣜࣔࣥ ࢧࢵࢱࣜ*ࠊᑠᯇᓮ Ẹᶞ : ࠕPredicting Bi-䠏䠌䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ1 ⣽⬊࣐ࣛࣥࢫ࣌ࢡࢺࣝ⏬ീ࠿ࡽᢳ

ological Cell Aggregation Using Scalable Random Forestฟࡍࡿ⣽⬊≧ែࢱ࢟ࢯࣀ࣑䇷ࠖࠊᖹᡂ 28 ᖺᗘ᪂ศ㔝๰

Decision TreesࠖࠊThe 18th RIES-Hokudai Internationalᡂࢭࣥࢱ࣮࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫ◊✲ศ㔝ࣉࣟࢪ

SymposiumࠊChateraise Gateaux Kingdom SapporoࠊJapan࢙ࢡࢺᡂᯝⓎ⾲఍ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ஦ົᒁ఍㆟ᐊ(2017-11 ࠥ 2017-12)(2017-03)

䠍䠕䠅 ᑠᯇᓮ Ẹᶞ*ࠊ୰ᮧ ⠜⚈ࠊ⸨⏣ ඞᫀࠊཎ⏣ ⩏つ :ࠕ࣐ࣛࣥศග࢖࣓࣮ࢪࣥࢢィ࡜᝟ሗ⛉Ꮫ࡜ࡢ㧗ᗘ⼥ྜࠖࠊ2017 ᖺᗘ ே࣭⎔ቃ࡜≀㉁ࢆࡘ࡞ࡄ࢖ࣀ࣮࣋䠏䠍䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ1 ⣽⬊࣐ࣛࣥศග࢖࣓࣮ࢪࣥࢢ⏬ീ࠿ࡽㄞࡳゎࡃ᝟ሗィ⛉Ꮫࠖࠊࣂ࢖࢜ィゎᯒᢏ⾡◊✲఍ࠊ࠿ࢇࡱࡢᐟ ᑠᶡ (2017-03)

ࢩࣙࣥ๰ฟ ࢲ࢖ࢼ࣑ࢵࢡ࢔ࣛ࢖࢔ࣥࢫ G3 ศ⛉఍࣮

䠏䠎䠅 G.Nishimura,”Optical tomography for near-infrared fluo-␗ศ㔝⼥ྜ࡜࢖ࣀ࣮࣋ࢩࣙࣥ๰ฟࢆ┠ᣦࡋ࡚࣮ࠊᮾ໭

rescence imaging”, Inverse problems and medical imaging,኱Ꮫ ∦ᖹ࢟ࣕࣥࣃࢫ ࡉࡃࡽ࣮࣍ࣝ / ⛅ಖGraduate school of mathematical science, The UniversityἨ ࣍ࢸࣝࢽ࣮ࣗỈᡞᒇࠊJapan (2017-11)䠎䠌䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ࣐ࣛࣥศග࢖࣓࣮ࢪࣥࢢ࡟࠾ࡅࡿ

of Tokyo (2017.2.13-17) 㸦ᣍᚅ㸧
䠏䠏䠅 K.Prieto, G.Nishimura “A new scheme for the time-do-ᢏ⾡ࡢᒎ㛤ࠖࠊᇶ┙(S) 㞳ᩓᵓ㐀ฎ⌮⣔ࣉࣟ

main fluorescence imaging of a semi-infinite turbid me-ࢪ࢙ࢡࢺ ࠕ2017 ᖺᗘ ⛅ࡢ࣮࣡ࢡࢩࣙࢵࣉࠖࠊ࣍ࢸࣝ

dium: Monte Carlo evalutation.” Inverse problems and஬࿡ࠊJapan (2017-11)

medical imaging, Graduate school of mathematical science,᝟ሗィ䠎䠍䠅 ⏣⏿ බḟ*ࠊ୰ᮧ ⠜⚈ࠊᮏከ ῟ஓࠊᑠᯇᓮ Ẹᶞ :The University of Tokyo (2017.2.13-17) 㸦ᣍᚅ㸧ࠕࢢࣞ࢖ࢰ࣮ࣥᖜࢆ฼⏝ࡋࡓᝏ⭎Ꮡᅾࢳ࢙ࢵࢡ࢔ࣝ

䠏䠐䠅 J. N. Taylor*ࠊᮤ ᣺㢼ࠊFujita Katsumasaࠊᑠᯇᓮ Ẹࢦࣜࢬ࣒ࠖࠊ➨ 20 ᅇ᝟ሗㄽⓗᏛ⩦⌮ㄽ࣮࣡ࢡࢩࣙࢵ

ᶞ : ࠕData-Driven Analysis of Raman Microscopic Im-ࣉࠊᮾி኱Ꮫᮏ㒓࢟ࣕࣥࣃࢫࠊJapan (2017-11)

agesࠖࠊ㟁Ꮚ⛉Ꮫ◊✲ᡤ ◊✲஺ὶ఍ࠊ㟁Ꮚ⛉Ꮫ◊✲ᡤࠊ䠎䠎䠅 ᒣ⏣ ᐶᏊ*ࠊᑠᯇᓮ Ẹᶞ : ࠕ࣐ࣛࣥࢫ࣌ࢡࢺ࡛ࣝ⣽㸯㝵఍㆟ᐊ (2017-01)⬊ࡢ⑓ែࢆศࡅࡿ㸫PCA ࡜ࣛࣥࢲ࣒ࣇ࢛ࣞࢫࢺࢆ⏝䠏䠑䠅 ᑠᯇᓮ Ẹᶞ* : ࠕศᏊ࠿ࡽ⣽⬊ࡢಶᛶ࡟㛵ࡍࡿࢹ࣮࠸࡚㸫ࠖࠊ◊✲఍ࠕ⌮ㄽ࡜ᐇ㦂ࠖ2017ࠊᗈᓥ኱Ꮫᮾᗈ

ࢱ㥑ືᆺᩘ⌮⛉Ꮫࠖࠊ➨ 1117 ᅇ⏕≀⛉Ꮫࢭ࣑ࢼ࣮ࠊᮾ

ᓥ࢟ࣕࣥࣃࢫࠊJapan (2017-10)ி኱Ꮫ⌮Ꮫ㒊 (2016-12)㸦ᣍᚅ㸧䠎䠏䠅 ఀ⸨ ๰♸* : ࠕ⏕໬Ꮫ᫬ィࡢ᝟ሗ⇕ຊᏛࠖࠊ◊✲఍ࠕ⌮䠏䠒䠅 K. M. Helal*, P. Nag, H. Teramoto, C. Li, H. Hisashi andㄽ࡜ᐇ㦂ࠖ2017ࠊᗈᓥ኱Ꮫᮾᗈᓥ࢟ࣕࣥࣃࢫࠊJapanT. Komatsuzaki : “Collective Cell Migration: Underlying(2017-10)

Dynamics and Emergent Structures of Heterogeneity”,

䠎䠐䠅 ఀ⸨ ๰♸* : ࠕLangevin ⣔࡟࠾ࡅࡿ⇕ຊᏛ, ᝟ሗ⇕ຊ

The

17th

RIES-HokudaiInternational

Symposium,

ᏛࠖࠊPerspectives of Nonlinear Phenomena in Random andChateraise Gateaux Kingdom Sapporo (2016-12)

Non-autonomous Dynamicsࠊி㒔኱Ꮫ ⌮Ꮫ㒊 3 ྕ㤋ࠊ䠏䠓䠅 P. Nag*, K. M. Helal, H. Teramoto, C. Li, H. Haga andJapan (2017-9) (ᣍᚅ).

T. Komatsuzaki : “Dynamical Heterogeneity During Col-䠎䠑䠅 ఀ⸨ ๰♸* : ࠕࢿࢵࢺ࣮࣡ࢡୖࡢ᝟ሗ⇕ຊᏛ࡜⏕య

lective Migration of MDCK Epithelial Monolayer”, Theࢩࢢࢼࣝఏ㐩࡬ࡢᛂ⏝ࠖࠊ➨ 62 ᅇ≀ᛶⱝᡭኟࡢᏛᰯࠊ

17th RIES-Hokudai International Symposium, Chateraiseࡂࡩ㛗Ⰻᕝ

Gateaux Kingdom Sapporo (2016-12)Ἠ࣍ࢸࣝࣃ࣮ࢡࠊ Japan (2017-8) 㸦ᣍᚅ㸧䠎䠒䠅 ᑎᮏ ኸ* : ࠕ≉␗Ⅼㄽ࡟ࡼࡿᅛ᭷್஺ᕪ㏆ഐ࡛ࡢࣁ䠏䠔䠅 J. N. Taylor*, C. Li, K. Fujita and T. Komatsuzaki :࣑ࣝࢺࢽ࢔ࣥࡢศ㢮ࠖࠊRIMS ඹྠ◊✲ ຊᏛ⣔ ࣮ ⌮“Data-Driven Approaches to Raman Microscopic ImageAnalysis”, The 17th RIES-Hokudai International Symposium, Chateraise Gateaux Kingdom Sapporo (2016-12)
䠏䠕䠅 Y. Tamiya*, C. Li, R. Watanabe, H. Noji and T. Komatsu-

䠐䠕䠅 T. Komatsuzaki* : “Single Molecule Biophysics: How can
One extract the Underlying Markovian/non-Markovian
Network from Noisy and Short Time Series?”, IXXI-ENS

zaki : “The Non-equilibrium Effects on Reaction Kinetics

Lyon seminar, ENS de Lyon, France (2016-06)㸦ᣍᚅ㸧

of F1-ATPase”, The 17th RIES-Hokudai International

䠑䠌䠅 T. Komatsuzaki* : “Defining Global Transition State over

Symposium, Chateraise Gateaux Kingdom Sapporo

an Entire Markov Network”, Seminar of the ICB/Nano-(2016-12)

sciences department, Laboratoire Interdisciplinaire Car-䠐䠌䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ୍⣽⬊࣐ࣛࣥィ࡜ࢫࣃ࣮ࢫᏛ⩦ࠊ

not de Bourgogne, France (2016-06)㸦ᣍᚅ㸧ࣂࣥࢹ࢕ࢵࢺᡭἲ࡞࡝ࡢ᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊䠑䠍䠅 T. Komatsuzaki* : “Single Molecule Biophysics: How canデ᩿ࡢ㎿㏿ゎᯒࠖࠊᇶ┙㸦S㸧㞳ᩓᵓ㐀ฎ⌮⣔ࣉࣟࢪ࢙One Dig the Underlying Network from Noisy and Shortࢡࢺࠕ2016 ᖺᗘ ⛅ࡢ࣮࣡ࢡࢩࣙࢵࣉࠖࠊ࢞ࢺ࣮࢟ࣥ

Time Series?”, Seminar of the ICB/Nanosciences depart-ࢢࢲ࣒࣭ࢧࢵ࣏ࣟ (2016-11)

ment, Laboratoire Interdisciplinaire Carnot de Bourgogne,䠐䠍䠅 ᑠᯇᓮ Ẹᶞ* : ࠕ୍⣽⬊࣐ࣛࣥィ࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊デ᩿ࡢ㎿㏿ゎᯒᢏ⾡ࡢ㛤Ⓨࠖࠊ㹁㹐㹃㹑

France (2016-06)㸦ᣍᚅ㸧䠑䠎䠅 T. Komatsuzaki* : “Defining Global Transition State overᢏ⾡࡜㧗ᗘ᝟ሗฎ⌮ࡢan Entire Markov Network”, Seminar at Beijing Compu-

⼥ྜ࡟ࡼࡿ࢖ࣥࢸࣜࢪ࢙ࣥࢺィ ࣭ゎᯒᡭἲࡢ㛤Ⓨ࡜

tational Science Research Center, Beijing Computational㹒࣭ࡉࡁࡀࡅ」ྜ㡿ᇦ ࠕィᛂ⏝ࠖ, ࢟ࢵࢡ࢜ࣇ఍㆟ࠊTKP ᕷࣨ㇂࢝ࣥࣇ࢓ࣞࣥࢫ

Science Research Center, China (2016-05)㸦ᣍᚅ㸧
䠑䠏䠅 C. Li* : “A Nano-Scale Key-and-Unlock Mechanism inࢭࣥࢱ࣮ (2016-11)㸦ᣍᚅ㸧䠐䠎䠅 ᑠᯇᓮ Ẹᶞ* : ࠕᑡᩘ⣔࠿ࡽ」㞧཯ᛂࢿࢵࢺ࣮࣡ࢡ

the F1-ATPase revealed by Single Molecule Time Seriesࢆྵࡴ㑄⛣≧ែᴫᛕࡢ῝໬࡜ไᚚࠖࠊ≉タศ㔝◊✲ࠕ㑄

Analysis”, Seminar at Beijing Computational Science Re-⛣≧ែไᚚࠖ◊✲௦⾲⪅஺ὶ఍ࠊ᪥ᮏᏛ⾡᣺⯆఍

search Center, Beijing Computational Science Research(2016-10)㸦ᣍᚅ㸧

Center, China (2016-05)㸦ᣍᚅ㸧

䠐䠏䠅 J. N. Taylor*, F. Katsumasa and T. Komatsuzaki : “Data-䠑䠐䠅 ᑠᯇᓮ Ẹᶞ*ࠊᑎᮏ ኸࠊᡞ⏣ ᖿேࠊἙ㔝 ⿱ᙪࠊ㧗

Driven Approaches to Raman Microscopic Image Analy-ᶫ ṇᙪ : ࠕ໬Ꮫ཯ᛂࡢ⾜ࡁඛࢆኚ࠼ࡿࢫ࢖ࢵࢳ䇷࢚sis”, ࠕ⌮ㄽ࡜ᐇ㦂ࠖ◊✲఍ 2016, ᗈᓥ኱Ꮫᮾᗈᓥ࢟

ࢿࣝࢠ࣮ࡢୖ࡛᪼཯ᛂ⤒㊰ࡀษࡾ᭰ࢃࡿ᪂ወ⌧㇟ࠖࠊࣕࣥࣃࢫ (2016-10)

㝃⨨◊✲ᡤ㛫࢔ࣛ࢖࢔ࣥࢫ࡟ࡼࡿࢼࣀ࡜࣐ࢡࣟࢆࡘ䠐䠐䠅 ⏣ᐑ ⿱἞* : ࠕᅇ㌿⮬⏤ᗘࡢ㠀ᖹ⾮ᛶࡀศᏊ࣮ࣔࢱ

࡞ࡄ≀㉁࣭ࢹࣂ࢖ࢫ࣭ࢩࢫࢸ࣒๰〇ᡓ␎ࣉࣟࢪ࢙ࢡࢺ

࣮F1-ATPase ࡢ཯ᛂືຊᏛ࡟ཬࡰࡍᙳ㡪࡟ࡘ࠸࡚ࠖࠊ

ᖹᡂ 27 ᖺᗘᡂᯝሗ࿌఍ࠊ኱㜰኱Ꮫ㖟ᮥ఍㤋 3 㝵ࠕ⌮ㄽ࡜ᐇ㦂ࠖ◊✲఍ 2016ࠊᗈᓥ኱Ꮫᮾᗈᓥ࢟ࣕࣥ

(2016-05)
䠑䠑䠅 H. Teramoto* : “Classification of Hamiltonians in neigh-ࣃࢫ (2016-10)
䠐䠑䠅 P. Nag* : “Spatio-temporal heterogeneity during collec-

borhoods of band crossings in terms of the theory of sin-tivemigration in a confluent monolayer of MDCK epithelial

gularities”, ᗄఱᏛࢥ࣒ࣟ࢟࢘, ໭ᾏ㐨኱Ꮫ⌮Ꮫ㒊 4cells”, ࠕ⌮ㄽ࡜ᐇ㦂ࠖ◊✲఍ 2016, ᗈᓥ኱Ꮫᮾᗈᓥ࢟

ྕ㤋 (2016-05)
䠑䠒䠅 ᑎᮏ ኸ* : ࠕ཯ᛂᗙᶆࢫ࢖ࢵࢳࣥࢢᶵᵓࡢ⫼ᬒࡢᴫࣕࣥࣃࢫ (2016-10)
䠐䠒䠅 T. Komatsuzaki* : “Molecular Functions and Energyㄝࠊព⩏࡜௒ᚋࡢᒎᮃࠖࠊ㧗ᶫ◊࣮࢜ࣉࣥࢭ࣑ࢼ࣮ࠊ

Landscapes Extracted from Single Molecule Time Seriesᮾ໭኱Ꮫከඖ≀㉁⛉Ꮫ◊✲ᡤ (2016-05)㸦ᣍᚅ㸧

Data”, HOKUDAI-NCTU Joint Symposium on Nano,䠑䠓䠅 ᑠᯇᓮ Ẹᶞ* : ࠕࢩࣟ࢖ࢾࢼࢬࢼࡢⴟ∦⤌⧊࡟ぢࡿ

Photo and Bio Sciences in 2016, Lecture Hall, Frontier᳜≀⣽⬊㞟ᅋࡢ᣺ື⌧㇟ࠖࠊ⌮◊ࢩ࣏ࣥࢪ࣒࢘: ⣽⬊Research in Applied sciences Building, Hokkaido Univer-ࢩࢫࢸ࣒ࡢືែ࡜ㄽ⌮ VIIIࠊ⌮໬Ꮫ◊✲ᡤ ⏕≀⛉Ꮫ◊✲Ჷ (2016-04)

sity (2016-10)㸦ᣍᚅ㸧
䠐䠓䠅 C. Li* : “Single Molecule Time Series Analyses of F1-

䠑䠔䠅 J. N. Taylor* : “Error-based Extraction of States and En-

ATPase to Unveil the Roles of ATP Hydrolysis”, ศᏊ◊ergy Landscapes from Experimental Single-Molecule◊✲఍ࠕ㉸ᶵ⬟ศᏊࡢ๰ᡂ-ྜᡂࠊィTime-Series”, Mathematical Sciences Evening Seminar,ࠊᩘ⌮ࡀ⧊ࡾ

࡞ࡍ♫఍ᐇ⿦ศᏊࡢᡓ␎ⓗタィ࡜㛤Ⓨ-ࠖ, ᒸᓮࢥࣥࣇ࢓ࣞࣥࢫࢭࣥࢱ࣮ (2016-06)㸦ᣍᚅ㸧໭ᾏ㐨኱Ꮫ㐲཭Ꮫ⯋ (2016-04)
䠑䠕䠅 ᑎᮏ ኸ*ࠊᡞ⏣ ᖿேࠊᑠᯇᓮ Ẹᶞ : ࠕClassification

䠐䠔䠅 T. Komatsuzaki* : “Phase Space geometry and Chemicalof Electron Energy Level Crossings in terms of the The-

Reaction Dynamics: Past, Present, and Future”, Seminar

ory of Singularities and Analysis of Non-Adiabatic Tran-of the ICB/Nanosciences department, Laboratoire Inter-sitions around the Crossingsࠖࠊ➨ 89 ᅇ⌧㇟ᩘ⌮ࢭ࣑ࢼ

disciplinaire Carnot de Bourgogne, France (2016-06)㸦ᣍᚅ㸧࣮ࠊ஑ᕞ኱Ꮫఀ㒔࢟ࣕࣥࣃࢫ (2016-04)
䠒䠌䠅 ᑎᮏ ኸ* : ࠕClassification of Electron EnergyLevel Crossings in terms of the Theory of Sin-precision algorithm to predict observation time-

gularities and Analysis of Non-Adiabatic Tran-scale hierarchy of an isomerization reaction

sitions around the Crossingsࠖࠊ೫ᚤศ᪉⛬ᘧጲ㊰

QHWZRUN͇ 7KH WK 5,(6-Hokudai International◊✲఍ࠊ࢖࣮ࢢࣞጲ㊰ (2016-03)

Symposium, Chateraise Gateaux Kingdom Sapporo

䠒䠍䠅 7.RPDWVX]DNL ͆0ROHFXODU'DWD6FLHQFH3HU

(2015-11)

spectives for Individuality Covering from Mole-

䠓䠍䠅 +7HUDPRWR ͆&ODVVLILFDWLRQDQG&RQWURORIFXOHV WR &HOOV͇ ⤫ྜ⏕࿨་⛉Ꮫ◊✲ࢭࣥࢱ࣮⑌

electron energy level crossings in terms of theᝈ⏕≀Ꮫࢭ࣑ࢼ࣮, ⌮໬Ꮫ◊✲ᡤᶓ὾࢟ࣕࣥࣃࢫWKHRU\ RI VLQJXODULW\͇ 7KH WK 5,(6-Hokudai(2016-03)

International Symposium , Chateraise Gateaux䠒䠎䠅 ᑠᯇᓮ Ẹᶞ* : ࠕᑡᩘᛶ⏕≀Ꮫࡢ᪂ᒎ㛤㸸ศᏊಶᛶ࠿ࡽ⣽⬊ಶᛶ࡬ࠖࠊ᪂Ꮫ⾡㡿ᇦࠕᑡᩘᛶ⏕≀Ꮫࠖ ◊✲ᡂᯝሗ࿌఍ࠊᮾி኱Ꮫ ఀ⸨ㅰᜠ࣮࣍ࣝ (2016-03)
䠒䠏䠅 C. Li*, H. Ueno, R. Watanabe, H. Noji and T.
.RPDWVX]DNL͆7KHNH\DQGXQORFNPHFKDQLVPVLQ
F1-ATPase unveiled by single molecule time seULHVDQDO\VLV͇᪂Ꮫ⾡㡿ᇦࠕᑡᩘᛶ⏕≀Ꮫࠖ ◊✲ᡂᯝሗ࿌఍, ᮾி኱Ꮫ ఀ⸨ㅰᜠ࣮࣍ࣝ (2016-03)

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Constructing Hidden Markov Model from Infor-䠓䠅

(2017 ᖺ 03 ᭶ 18 ᪥ࠥ2017 ᖺ 03 ᭶ 20 ᪥)

Mathematics, Computer Science and Bioinformatics,䠔䠅ᑠᯇᓮ Ẹᶞ : ࠕࣂ࢖࢜ィ䠕䠅ᑠᯇᓮ Ẹᶞࠊ෠ᶔ ♸୍ : ࠕᑡᩘᛶ⏕≀Ꮫ◊✲఍᪩✄⏣኱Ꮫす᪩✄⏣࢟ࣕࣥࣃࢫ (2015-04)
䠍䠌䠒䠅 ᑠᯇᓮ Ẹᶞࠊᡞ⏣ ᖿேࠊᑎᮏ ኸ*ࠊἙ㔝 ⿱ᙪࠊ㧗ᶫ ṇᙪ : ࠕA Global Dynamical Switching of aゎᯒࣉࣞ◊✲఍ࠖࠊ7 ேࠊ࠿ࢇࡱࡢᐟ ᑠᶡ (໭ᾏ㐨ᑠᶡᕷ) (2017 ᖺ 03 ᭶ 17 ᪥)䠍䠌䠑䠅 ὠᕝ ᬡ*ࠊᮤ ᣺㢼ࠊᑠᯇᓮ Ẹᶞ: ࠕ⺯ග⏬ീ࠿ࡽᚤᑠ⟶㓄ྥᵓ㐀ࡢᢳฟࠖࠊ᪩✄⏣኱Ꮫ┦⃝◊✲ᐊ◊✲఍ࠊゎᯒ◊✲఍ࠖࠊ23 ேࠊ࠿ࢇࡱࡢᐟ ᑠᶡ (໭ᾏ㐨ᑠᶡᕷ)PDWLRQ7KHRU\͇'HSDUWPHQWWDON'HSDUWPHQWRI
Free University of Berlin, Germany (2015-04)Ọ஭ ೺἞ࠊ㮖ᑿ 㝯ࠊᑠᯇᓮ Ẹᶞ : ࠕࣂ࢖࢜ィ

2016㹼ᑡᩘᛶ⏕≀Ꮫࡢᮍ᮶ࢆㄒࡿ㹼ࠖࠊᐃᒣ῱୓ୡ㛶࣍ࢸ࣑࣮ࣝࣜ࢜ࢿ (໭ᾏ㐨ᮐᖠᕷ) (2016 ᖺ 02 ᭶ 14
᪥ࠥ2016 ᖺ 02 ᭶ 16 ᪥)

Reaction Coordinate and its Experimental Observ-

䠍䠌䠅 7.RPDWVX]DNL-:XDQG-:DQJ͆'HFLSKHU

abilityࠖࠊᖹᡂ26ᖺᗘ࢔ࣛ࢖࢔ࣥࢫᡂᯝሗ࿌఍ࠊ஑ᕞ

ing molecular complexity from protein functions኱Ꮫ ఀ㒔࢟ࣕࣥࣃࢫ (2015-04)

WRFHOOXODUQHWZRUN͇+DZDLL&RQYHQWLRQ&HQWHU䠍䠌䠓䠅 ὠᕝ ᬡ*ࠊᮤ ᣺㢼ࠊᑠᯇᓮ Ẹᶞ: ࠕ⺯ග⏬ീ࠿ࡽᚤᑠ⟶㓄ྥᵓ㐀ࢆᢳฟࡍࡿ᪉ἲ࡟ࡘ࠸࡚ࠖࠊ⌮◊ࢩ࣏ࣥࢪ࣒࢘ࠕ⣽⬊ࢩࢫࢸ࣒ࡢືែ࡜ㄽ⌮ Ϯࠖࠊ⌮໬Ꮫ◊✲ᡤ ⏕≀⛉Ꮫ◊✲Ჷ (2015-04)
䠍䠌䠔䠅 ⏣ᐑ ⿱἞*ࠊᮤ ᣺㢼ࠊΏ㑓 ຊஓࠊ㔝ᆅ ༤⾜ࠊᑠᯇ(Hawaii, U.S. USA) (2015 ᖺ 12 ᭶ 15 ᪥ࠥ2015 ᖺ
12 ᭶ 16 ᪥)
䠍䠍䠅 7.RPDWVX]DNL͆7KHZRUNVKRS͆7KHRU\RI*DV
Phase Scattering and Reactivity for AstrophysLFV͇DORQJ&267͂2XU$VWURFKHPLFDO+LVWRU\̓ᓮ Ẹᶞ: ࠕF1 ศᏊ࣮ࣔࢱ࣮ࡢ ᗘ౫Ꮡᛶࠖࠊ⌮◊ࢩ

$FWLRQ&0͇0,$33Max Planck Institute࣏ࣥࢪ࣒࢘ࠕ⣽⬊ࢩࢫࢸ࣒ࡢືែ࡜ㄽ⌮ Ϯࠖࠊ⌮໬Ꮫ

(Garching, Germany Germany) (2015 ᖺ 11 ᭶ 23 ᪥◊✲ᡤ ⏕≀⛉Ꮫ◊✲Ჷ (2015-04)

ࠥ2015 ᖺ 12 ᭶ 08 ᪥)
䠍䠎䠅 71HPRWR7.RPDWVX]DNLDQG.2WRPR͆7RS-

4.6 ࢩ࣏ࣥࢪ࣒࢘ࡢ㛤ദCollaboration Support Project International䠍䠅ᑎᮏ ኸࠊᒣᒸ 㞞┤ : ࠕAIMaP ࣮࣡ࢡࢩࣙࢵࣉࠕ㠀

Lecture also as Nikon Imaging Center at Hok-ࣀ࢖࣐ࣥᆺィ⟬ࠊ⌮ㄽ࡜ᛂ⏝ࠖࠊ໭ᾏ㐨኱Ꮫ㟁Ꮚ⛉Ꮫ

NDLGR8QLY,QWHUQDWLRQDO/HFWXUH͇ ே,◊✲ᡤ (໭ᾏ㐨ᮐᖠᕷ) (2018 ᖺ 03 ᭶ 30 ᪥)RIES, Hokkaido University (Sapporo) (2015 ᖺ 11
᭶ 19 ᪥)㹠. ⏘ᴗ⏺➼࡜ࡢඹྠ◊✲䠍䠏䠅 ᑠᯇᓮ Ẹᶞࠊᑎᮏ ኸ : ࠕᩘᏛ࡜໬Ꮫࡢ⼥ྜ࡟㛵ࡍ㸯)ࡿ◊✲㞟఍ࠕ኱⮬⏤ᗘศᏊ ⣔࡟࠾ࡅࡿ໬Ꮫ཯ᛂᶵᗎ
ࡢ⌮ゎ࡜ไᚚࠖࠖࠊ໭ᾏ㐨኱Ꮫ (໭ᾏ㐨ᮐᖠᕷ) (2015ᰴᘧ఍♫᪥❧〇సᡤࠕᩘ⌮ࣔࢹࣝ࡜ࣁ࣮ࢻ࢙࢘࢔࢔ࣝ
ࢦࣜࢬ࣒࡟ᇶ࡙ࡃ♫఍ᛂ⏝ࠖ2016-2018 ᖺᗘ㸰)ᖺ 10 ᭶ 31 ᪥ࠥ2015 ᖺ 11 ᭶ 01 ᪥)ᰴᘧ఍♫ࢽࢥࣥࠕගᏛⓗᡭἲࢆ⏝࠸ࡓ⏕య⤌⧊ィ ᢏ⾡࡟㛵ࡍࡿᛂ⏝◊✲ࠖ2015.6-2019.7

䠍䠐䠅 Berry StephenࠊKeshavamurthy Srihariࠊᑎᮏ ኸࠊ
Waalkens Holger : ࠕGeometry of Chemical Reaction㹡. ᅜ㝿ඹྠ◊✲Dynamics in Gas and Condensed PhasesࠖࠊTelluride䠍䠅 ᮤ ᣺㢼, ᑠᯇᓮ Ẹᶞ (໭ᾏ㐨኱Ꮫ)ࠊArezki BoudaoudElementary School 447 West Columbia Ave (Tellu-㸦ࣜࣚࣥ㧗➼ᖌ⠊Ꮫᰯ㸧ࠊAdrienne Roeder㸦ࢥ࣮ࢿࣝ኱㸧ࠊ

ride USA) (2015 ᖺ 07 ᭶ 27 ᪥ࠥ2015 ᖺ 08 ᭶ 07 ᪥)

Richard S. Smith㸦ࢥࣥࢫࢱࣥࢶ኱㸧࡜ࡢᅜ㝿ඹྠ◊✲ࠕFrom stochastic cell behavior to reproducible

䠍䠑䠅 T. Komatsuzaki, S. Presse and R. S. Berry :͆7KH&RPSOH[LW\RI'\QDPLFVDQG.LQHWLFVIURPshapes: the coordination behind morphogenesisࠖࠊ

6LQJOH0ROHFXOHVWR&HOOV͇7HOOXULGH(OHPHQ

2013-2016ᖺᗘ ᅜ㝿ࣄ࣮࣐࣭ࣗࣥࣇࣟࣥࢸ࢕࢔࣭ࢧ࢖
࢚ࣥࢫ࣭ࣉࣟࢢ࣒ࣛ

tary School (Telluride USA) (2015 ᖺ 06 ᭶ 14 ᪥䠎䠅 J. N. Taylor, ᑠᯇᓮẸᶞ㸦໭ᾏ㐨኱Ꮫ㸧ࠊGilad Haran

ࠥ2015 ᖺ 06 ᭶ 18 ᪥)䠍䠒䠅 Ṋḟ ᚭஓࠊ㣤᳃ ಇᩥࠊᒾబ ㇦ࠊኴ⏣ ಙᘅࠊᑠᯘ

㸦࣡࢖ࣥࢬ࣐ࣥ◊✲ᡤࠊ࢖ࢫ࢚ࣛࣝ㸧࡜ࡢᅜ㝿ඹྠ◊✲ṇேࠊᑠᯇᓮ Ẹᶞࠊబ⸨ ಙ୍㑻ࠊᑎᮏ ኸࠊ୰㇂ࠕAKࢱࣥࣃࢡ㉁ࡢᢡࡾࡓࡓࡳ୍ศᏊほᐹ࠿ࡽࡢ࢚ࢿࣝ
ࢠ࣮ᆅᙧ෌ᵓᡂࠖ

┤㍤ࠊ୰ᒣ ဴࠊ㛗㇂ᕝ ῟ஓࠊᘅᕝ ῟ࠊ๓⏣ ⌮ࠊΏ㒊 ┤ᶞ : ࠕ➨ 31 ᅇ໬Ꮫ཯ᛂウㄽ఍ࠖࠊ໭ᾏ㐨኱䠏䠅 ᑠᯇᓮẸᶞ㸦໭ᾏ㐨኱Ꮫ㸧ࠊRigoberto Hernandez 㸦ࢪᏛᕤᏛ㒊ࣇࣟࣥࢸ࢕࢔ᛂ⏝⛉Ꮫ◊✲Ჷ (ᮐᖠᕷ)ࣙࣥࢬ࣭࣍ࣉ࢟ࣥࢫ኱Ꮫ㸧࡜ࡢᅜ㝿ඹྠ◊✲ࠕ໬Ꮫ཯(2015 ᖺ 06 ᭶ 03 ᪥)ᛂືຊᏛ࡟࠾ࡅࡿ┦✵㛫ᵓ㐀⌮ㄽࠖ䠍䠓䠅 *1LVKLPXUD͆WK$VLDQDQG3DFLILF5LP6\P
posium on Biophotonics

䠐䠅 ᑠᯇᓮ Ẹᶞࠊᑎᮏ ኸ(໭ᾏ㐨኱Ꮫ)ࠊࢳ࣮ࣗࣜࢵࣄᕤ
⛉኱Ꮫ㸦George Haller㸧࡜ࡢࣛࢢࣛࣥࢪࣗ༠ྠᵓ㐀࡟(APBP'20 ͇3DFLI㛵ࡍࡿᩘ⌮◊✲

ico Yokohama (Yokohama) (2015 ᖺ 04 ᭶ 22 ᪥ࠥ24

䠑䠅 すᮧ

᪥)

࿃ᮁ(໭ᾏ㐨኱Ꮫ)ࠊJijun Liu(ᮾ༡኱Ꮫ)ࠊ⏫⏣Ꮫ(὾ᯇ་኱)ࠊ୰ᮧ

⋞(໭ᾏ㐨኱Ꮫ)࡜ࡢᅜ㝿ඹྠ◊

4.7 ඹྠ◊✲✲ࠕᣑᩓ⺯ගࢺࣔࢢࣛࣇ࢕ᡭἲ࡟㛵ࡍࡿᩘ⌮◊✲ࠖ

㹟. ᅜෆ኱Ꮫࠊ◊✲ᶵ㛵࡜ࡢඹྠ◊✲(2017ᖺᗘ㹼)1㸧 ዉⰋዪᏊ኱Ꮫ⌮Ꮫ㒊≀⌮Ꮫ⛉ ᡞ⏣ᖿேࠕ໬Ꮫ཯ᛂࡢ
2㸧ືຊᏛ࡜࢝࢜ࢫࠖ2007ᖺᗘ-⌧ᅾd.እᅜே◊✲⪅ࡢᣍ⪸኱㜰኱Ꮫ኱Ꮫ㝔ᕤᏛ◊✲⛉ ⢭ᐦ⛉Ꮫ࣭ᛂ⏝≀⌮Ꮫᑓ䠍䠅ᨷ⸨⏣ඞᫀࠕ୍⣽⬊࣐ࣛࣥィ ࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊デ᩿ࡢ㎿㏿ゎᯒᢏ⾡ࡢ㛤Ⓨࠊ2016 ᖺᗘ-⌧ᅾ3㸧

ᖺ 09 ᭶ 27 ᪥㸧䠎䠅ி㒔ᗓ❧་⛉኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉ ཎ⏣⩏つࠕ୍⣽⬊࣐ࣛࣥィ࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊デ᩿ࡢ㎿㏿䠏䠅໭ᾏ㐨኱Ꮫ኱Ꮫ㝔᝟ሗ⛉Ꮫ◊✲⛉ᕤᏛ◊✲⛉ ୰ᮧ⠜᩿ࡢ㎿㏿ゎᯒᢏ⾡ࡢ㛤Ⓨࠊ2016 ᖺᗘ-⌧ᅾ

5㸧 ᮾி኱ᏛᕤᏛ◊✲⛉ᛂ⏝໬Ꮫᑓᨷ䠐䠅໭ᾏ㐨኱Ꮫ⌮Ꮫ◊✲㝔໬Ꮫᑓᨷ9㸧 ᮾ໭኱Ꮫ⌮Ꮫ◊✲⛉໬Ꮫᑓᨷ࢖ࢵࢳࣥࢢ࡛ᐇ㦂ⓗ᳨ドࠖ2015ᖺᗘ䠒䠅Ἑ㔝⿱ᙪࠕ཯ᛂᗙᶆࢫDavid AlloucheࠊFranceࠊ㸦2017 ᖺ 05 ᭶ 01 ᪥ࠥ2017 ᖺ
05 ᭶ 02 ᪥㸧䠓䠅Andrey GritsenkoࠊUnited States of Americaࠊ㸦2017 ᖺ
04 ᭶ 04 ᪥ࠥ2017 ᖺ 04 ᭶ 30 ᪥㸧䠔䠅Patrick SenetࠊFranceࠊ㸦2016 ᖺ 11 ᭶ 12 ᪥ࠥ2016 ᖺ
11 ᭶ 17 ᪥㸧㧗ᶫṇᙪࠕ཯ᛂᗙᶆࢫ

࢖ࢵࢳࣥࢢ࡛ᐇ㦂ⓗ᳨ドࠖ2015ᖺᗘ-

Jason Roger GreenࠊUnited States of Americaࠊ㸦2017 ᖺ
06 ᭶ 12 ᪥ࠥ2017 ᖺ 08 ᭶ 11 ᪥㸧Ṋḟᚭஓࠊ๓⏣⌮ࠕ཯ᛂࢿࢵࢺ࣮࣡ࢡ࡟㛵ࡍࡿࢢࣛࣇ⌮ㄽࠖ2015㸫2016ᖺᗘ
8㸧 ᮾ໭኱Ꮫከඖ≀㉁⛉Ꮫ◊✲ᡤ䠑䠅Ἠᒇ࿘୍ࠕᛂ⏝≉␗Ⅼㄽࡢ≀㉁⛉Ꮫ࡬ࡢᛂ⏝ࠖ2016 ᖺᗘ-⌧ᅾ

Sky NicholsonࠊUnited States of Americaࠊ㸦2017 ᖺ 07
᭶ 11 ᪥ࠥ2017 ᖺ 08 ᭶ 07 ᪥㸧㔝ᆅ ༤⾜ࠕF1 ศᏊ࣮ࣔࢱ࣮ࡢࢹ࣮ࢱ㥑ືᆺᩘ⌮⛉Ꮫࠖ2010-2018 ᖺᗘ

7㸧

Bi-Chang ChenࠊTaiwan (Province of China)ࠊ㸦2017 ᖺ
07 ᭶ 31 ᪥㸧⚈ࠕ୍⣽⬊࣐ࣛࣥィ ࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊デ6㸧 ໭ᾏ㐨኱Ꮫ⌮Ꮫ◊✲㝔ᩘᏛᑓᨷ

Arezki BoudaoudࠊFrance㸦2017 ᖺ 07 ᭶ 31 ᪥ࠥ2017
ᖺ 08 ᭶ 01 ᪥㸧ゎᯒᢏ⾡ࡢ㛤Ⓨࠊ2016 ᖺᗘ-⌧ᅾ
4㸧

Henry ArguelloࠊColombia㸦2017 ᖺ 09 ᭶ 25 ᪥ࠥ2017䠕䠅

Srihari KeshavamurthyࠊIndiaࠊ㸦2016 ᖺ 11 ᭶ 09 ᪥ࠥ
2016 ᖺ 11 ᭶ 10 ᪥㸧䠍䠌䠅 Nathan HervieuxࠊFranceࠊ㸦2016 ᖺ 08 ᭶ 20 ᪥ࠥ2016ᖺ 08 ᭶ 28 ᪥㸧䠑)䠍䠍䠅 Kai-Chun ChangࠊTaiwanࠊ㸦2016 ᖺ 08 ᭶ 15 ᪥ࠥ2016

C.B. Li㸦ᅜ㝿ࣄ࣮࣐࣭ࣗࣥࣇࣟࣥࢸ࢕࢔࣭ࢧ࢖࢚ࣥ
ࢫ࣭ࣉࣟࢢ࣒ࣛ᥎㐍ᶵᵓ㸧㸸͆)URPVWRFKDVWLFFHOO

ᖺ 08 ᭶ 18 ᪥㸧

behavior to reproducible shapes: the coordi-na-

䠍䠎䠅 Kevin MitchellࠊUSAࠊ
㸦2016 ᖺ 08 ᭶ 14 ᪥ࠥ2016 ᖺ 08

WLRQEHKLQGPRUSKRJHQHVLV͇㹼2016 ᖺᗘ, A.

᭶ 19 ᪥㸧

Boudaoud (ࣜࣚࣥ㧗➼ᖌ⠊Ꮫᰯ), A. Roeder㸦ࢥ࣮ࢿ

䠍䠏䠅 Sulimon SattariࠊUSAࠊ㸦2016ᖺ05᭶28᪥ࠥ2016ᖺ09᭶
11᪥㸧ࣝ኱㸧, R. Smith㸦ࢥࣥࢫࢱࣥࢶ኱㸧࡜ࡢඹྠ◊✲䠒)すᮧ ࿃ᮁࠊ་⒪ศ㔝◊✲ᡂᯝᒎ㛤஦ᴗࠊ⏘Ꮫඹ๰ᇶ♏ᇶ┙◊✲ࣉࣟࢢ࣒ࣛ㸸ࠕࣄࢺ⤌⧊῝㒊ࡢ࢖࣓࣮ࢪࣥ

4.8 ண⟬⋓ᚓ≧ἣ㸦◊✲௦⾲⪅ࠊศ㢮ࠊ◊✲ㄢ㢟ࠊᮇ㛫㸧ࢢࢆྍ⬟࡜ࡍࡿᐃ㔞ⓗ⺯ගศᏊ࢖࣓࣮ࢪࣥࢢᇶ┙ᢏ㹟㸬 ⛉Ꮫ◊✲㈝⿵ຓ㔠⾡ࡢ☜❧ࠖࠊ2011㹼2016 ᖺᗘࠊ᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ䠍䠅ᑠᯇᓮ Ẹᶞࠊᇶ┙◊✲ B ≉タศ㔝◊✲ࠊᑡᩘ⣔࠿ࡽ」㞧཯ᛂࢿࢵࢺ࣮࣡ࢡࢆྵࡴ㑄⛣≧ែᴫᛕࡢ῝໬࡜
ไᚚࠊ2015ࠥ2017 ᖺᗘ䠎䠅ᑠᯇᓮ Ẹᶞࠊ᪂Ꮫ⾡㡿ᇦ◊✲ࠊከ㝵ᒙࢩࢫࢸ࣒⏕≀Ꮫ࡟࠾ࡅࡿࢹ࣮ࢱ㥑ື⛉Ꮫࡢᒎ㛤ࠊ2017 ᖺᗘ䠏䠅䠐䠅

4.9 ཷ㈹㸯) Ọᖭ ⿱: ➨ 31 ᅇ໬Ꮫ཯ᛂウㄽ఍ࠕ࣋ࢫࢺ࣏ࢫࢱ࣮
㈹ࠖ 2015 ᖺ 6 ᭶㸰) Ọᖭ⿱:➨㸷ᅇศᏊ⛉Ꮫウㄽ఍(ᮾி)ࠕศᏊ⛉Ꮫ఍ඃ⚽࣏ࢫࢱ࣮㈹ࠖ2015 ᖺ 10 ᭶ᑠᯇᓮ Ẹᶞࠊⴌⱆ◊✲ࠊ⣽⬊ࡢ㞟ᅋ࡜ᑡᩘᛶࡢࢩࢫ
ࢸ࣒⏕≀Ꮫࠊ2016ࠥ2018 ᖺᗘ

4.10 ࢔࢘ࢺ࣮ࣜࢳάື

ᑠᯇᓮ Ẹᶞࠊᇶ┙◊✲ B ࠊ⏕࿨ືែࢩࢫࢸ࣒࡟ᑐࡍ

䠍䠅ࡿศᏊࢹ࣮ࢱ⛉Ꮫࡢᵓ⠏ࠊ2017ࠥ2019 ᖺᗘ䠑䠅ఀ⸨ ๰♸ࠊⱝᡭ

䠒䠅䠓䠅ᖹᡂ30ᖺᗘ໭ᾏ㐨኱Ꮫබ㛤ㅮᗙࠕཤࡿ᫬௦ࠊ᮶ࡓࡿ

㹀ࠊࢩࢢࢼࣝఏ㐩⣔ࡢ᝟ሗ⇕ຊᏛࠊ

2017 ᖺᗘ

᫬௦ࢆ⪃࠼ࡿࠖࠊ໭ᾏ㐨኱Ꮫ㸦2018.7.2㸧
䠎䠅࡜ࡢ⛉Ꮫ࣭ᢏ⾡ᑐヰฟᙇㅮ⩏ࠊࠕග࡛⏕యࢆぢࡿ㸟ࠖᏛ࡟࠾ࡅࡿࢹ࣮ࢱ㥑ື⛉Ꮫࡢᒎ㛤ࠊ2016 ᖺᗘ(2016.10.25)

ᮤ ᣺㢼ࠊᇶ┙◊✲ BࠊData-driven Multiscale Modelingᑎᮏ䠏䠅㒊Ꮫ཭఍㤋ࠕࣇࣛࢸࠖ㸦2015.9.11㸧
䠐䠅

J. N. Taylorࠊⱝᡭ BࠊNew Data-Driven Tools to Quantify
Heterogeneous Microenvironments in Love Cell Imagesࠊ㝵ᒙᛶࡢほⅬ࠿ࡽࡢࣔࢹࣜࣥࢢ㸫2011㹼2015ᖺᗘ䠍䠍䠅 ᑠᯇᓮ Ẹᶞࠊᇶ┙◊✲ Bࠊ㝵ᒙᛶ࡜㡹೺ᛶࢆࡶࡘ⏕࿨ືែࢩࢫࢸ࣒ࡢゎᯒᇶ┙ᵓ⠏ࠊ2013ࠥ2015ᖺᗘ䠍䠎䠅 ᑠᯇᓮ Ẹᶞࠊⴌⱆ◊✲ࠊศᏊಶᛶࢆ᙮ࡾฟࡍࢩࢫࢸ
࣒⏕≀Ꮫࡢ᥈ồࠊ2013ࠥ2015ᖺᗘ㹠㸬኱ᆺࣉࣟࢪ࢙ࢡࢺ࣭ཷク◊✲࡜᝟ሗ⛉Ꮫࡢ⼥ྜ࡟ࡼࡿ⣽⬊デ᩿ࡢ㎿㏿ゎᯒᢏ⾡ࡢ㛤Ⓨࠊ2016㹼
2021 ᖺᗘࠊ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ䠎)ᑠᯇᓮ Ẹᶞࠊᰴᘧ఍♫᪥❧〇సᡤ)ࠊᩘ⌮ࣔࢹࣝ࡜ࣁ
࣮ࢻ࢙࢘࢔࢔ࣝࢦࣜࢬ࣒࡟ᇶ࡙ࡃ♫఍ᛂ⏝ࠊ2016ࠥ
2018 ᖺᗘ

䠏)ᑎᮏኸࠊࡉࡁࡀࡅࠊ≉␗Ⅼㄽࡢ≀㉁⛉Ꮫ࡬ࡢᛂ⏝ࠊ

2016㹼2019 ᖺᗘࠊ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ䠐)すᮧ࿃ᮁࠊ㐃ᦠ༠ᐃά⏝ᆺ஦ᴗࠕᵓ㐀໬↷᫂࡜ᶵᲔᏛ
⩦࡟ࡼࡿᩓ஘፹యෆ㒊ࡢ᳨ᰝᢏ⾡࡟㛵ࡍࡿㄪᰝ◊✲䛃໭ᾏ㐨⥲ྜ◊✲ᶵᵓ, 2017.7.-2018.2

ఀ⸨๰♸ࠊ➨62ᅇ≀ᛶⱝᡭኟࡢᏛᰯ 㞟୰ࢮ࣑. ࡂࡩ㛗Ⰻᕝᢸ,ᑡᩘศᏊ཯ᛂࢿࢵࢺ࣮࣡ࢡ⌮ㄽࡢᵓ⠏㸫ᑡᩘᛶ࡜ᑠᯇᓮ ẸᶞࠊCRESTࠊ୍⣽⬊࣐ࣛࣥィᑠᯇᓮẸᶞࠊ㞟୰ㅮ⩏ࠕ≀⌮Ꮫ≉ูㅮ⩏➨୕㸦ศᏊࢹ࣮ࢱ⛉Ꮫ㸧
ࠖ୰ኸ኱Ꮫ㸦2015.9.2-4㸧䠑䠅2015㹼2016 ᖺᗘ䠍䠌䠅 ᑠᯇᓮ Ẹᶞࠊ᪂Ꮫ⾡㡿ᇦࠕᑡᩘᛶ⏕≀Ꮫࠖィ⏬⌜ศ䠍)ᑠᯇᓮẸᶞࠊࠕᑂᰝဨࡢ⤒㦂࠿ࡽࡳࡓ࣏࢖ࣥࢺࠖࠊ
ᖹᡂ㸰㸵ᖺᗘ ໭ᾏ㐨኱Ꮫ⛉◊㈝⏦ㄳࢭ࣑ࢼ࣮ࠊ་Ꮫ

ኸࠊⱝᡭ 㹀ࠊ཯ᛂᗙᶆࢫ࢖ࢵࢳࣥࢢᶵᵓࡢ」㞧ศᏊ⣔࡬ࡢᒎ㛤ࠊ2016 ᖺᗘ䠕䠅すᮧ ࿃ᮁࠊ㧗ᰯ⏕(໭ᾏ㐨❧ᮐᖠす㧗➼Ꮫᰯ)ࠊᅜẸᑠᯇᓮ Ẹᶞࠊ᪂Ꮫ⾡㡿ᇦ◊✲ࠊከ㝵ᒙࢩࢫࢸ࣒⏕≀of Signal Processing in Bacterial Chemotaxisࠊ2016 ᖺᗘ䠔䠅ᑠᯇᓮẸᶞࠊࠕ᪂ᴫᛕࢥࣥࣆ࣮ࣗࢸ࢕ࣥࢢ࡜ࡣ㸽ࠖ䠒䠅ᑎᮏἨ࣍ࢸࣝࣃ࣮ࢡ, (2017-8) .
ኸࠊ⍇⍈†≉␗Ⅼㄽ࣮࣡ࢡࢩࣙࢵࣉ

ㅮᖌࠊ኱ὠᕷࠊࣅ࣮ࣗࣟࢵࢪ⍇⍈⍚ (2017.12.20-22)