(A) KEGG pathway maps enriched in 80 canonical componenets (CCs)ID

Pathway map

P-value (log)################################### CC1 ###################################none################################### CC2 ###################################
map04727

GABAergic synapse

map04080

Neuroactive ligand-receptor interaction

20.1
11.858################################### CC3 ###################################
map04970

Salivary secretion

2.661################################### CC4 ###################################
map04020

Calcium signaling pathway

map04260

Cardiac muscle contraction

16.80613.71

map04728

Dopaminergic synapse

11.147map04010

MAPK signaling pathway

10.617map04970

Salivary secretion

5.762

map04270

Vascular smooth muscle contraction

5.665

map04740

Olfactory transduction

3.839

map04912

GnRH signaling pathway

3.389

map04070

Phosphatidylinositol signaling system

3.309

map04725

Cholinergic synapse

3.108

map04744

Phototransduction

2.461

map04720

Long-term potentiation

2.37

map04114

Oocyte meiosis

2.032################################### CC5 ###################################
map00590

Arachidonic acid metabolism

5.62

map04742

Taste transduction

1.895################################### CC6 ###################################none################################### CC7 ###################################
map00590

Arachidonic acid metabolism

1.794################################### CC8 ###################################
map04728

Dopaminergic synapse

1.484################################### CC9 ###################################
map04080

Neuroactive ligand-receptor interaction

11.977map04728

Dopaminergic synapse

3.538

map04020

Calcium signaling pathway

2.079################################### CC10 ###################################none################################### CC11 ###################################none################################### CC12 ###################################
map04080

Neuroactive ligand-receptor interaction

3.835

map04740

Olfactory transduction

3.535

map04744

Phototransduction

2.682

map04725

Cholinergic synapse

2.156

map04070

Phosphatidylinositol signaling system

1.747

map04910

Insulin signaling pathway

1.373################################### CC13 ###################################none################################### CC14 ###################################
map00590

Arachidonic acid metabolism

1.736################################### CC15 ###################################none################################### CC16 ###################################
map04260

Cardiac muscle contraction

17.189map04010

MAPK signaling pathway

12.905map04020

Calcium signaling pathway

5.762

map04725

Cholinergic synapse

3.165

map04728

Dopaminergic synapse

2.026

map04727

GABAergic synapse

1.873

map04912

GnRH signaling pathway

1.609

map04270

Vascular smooth muscle contraction

1.403################################### CC17 ###################################
map04080

Neuroactive ligand-receptor interaction

7.946

map04970

Salivary secretion

4.724

map04020

Calcium signaling pathway

3.283

map04725

Cholinergic synapse

2.442

map04270

Vascular smooth muscle contraction

1.546################################### CC18 ###################################
map04728

Dopaminergic synapse

1.872################################### CC19 ###################################none################################### CC20 ###################################none################################### CC21 ###################################
map03050

Proteasome

50.746################################### CC22 ###################################none################################### CC23 ###################################
map04080

Neuroactive ligand-receptor interaction

7.293

map04728

Dopaminergic synapse

4.146

map04970

Salivary secretion

2.122

map04742

map04020

Calcium signaling pathway

1.863################################### CC34 ###################################

Taste transduction

1.403################################### CC24 ###################################

map00120

Primary bile acid biosynthesis

8.599

map04080

Neuroactive ligand-receptor interaction

24.344map00140

Steroid hormone biosynthesis

4.803

map04727

GABAergic synapse

12.392map00100

Steroid biosynthesis

2.343################################### CC25 ###################################

map03320

PPAR signaling pathway

1.519

map00590################################### CC35 ###################################

Arachidonic acid metabolism

4.506################################### CC26 ###################################

map04727

GABAergic synapse

map04010

MAPK signaling pathway

16.806map04080

Neuroactive ligand-receptor interaction

20.1

map04260

Cardiac muscle contraction

15.745################################### CC36 ###################################

map04020

Calcium signaling pathway

5.193

map04010

MAPK signaling pathway

8.524

map04725

Cholinergic synapse

3.406

map04260

Cardiac muscle contraction

6.349

map04728

Dopaminergic synapse

2.169

map00590

Arachidonic acid metabolism

4.509

map04727

GABAergic synapse

2.035

map04020

Calcium signaling pathway

2.079

map04912

GnRH signaling pathway

1.783################################### CC37 ###################################

map04270

Vascular smooth muscle contraction

11.8581.546

map04080

Neuroactive ligand-receptor interaction

15.158################################### CC27 ###################################

map04727

GABAergic synapse

14.898none################################### CC38 ###################################################################### CC28 ###################################

none

map04727

GABAergic synapse

15.745################################### CC39 ###################################

map04080

Neuroactive ligand-receptor interaction

13.45

map04260

Cardiac muscle contraction

13.836################################### CC29 ###################################

map04020

Calcium signaling pathway

10.165map04080

Neuroactive ligand-receptor interaction

5.669

map04010

MAPK signaling pathway

9.641

map04740

Olfactory transduction

3

map04970

Salivary secretion

5.848

map04725

Cholinergic synapse

2.187

map04270

Vascular smooth muscle contraction

3.061

map04744

Phototransduction

2.149

map04728

Dopaminergic synapse

2.428

map04970

Salivary secretion

2.035################################### CC40 ###################################

map04971

Gastric acid secretion

1.995

none

map04964

Proximal tubule bicarbonate reclamation

1.602################################### CC41 ###################################################################### CC30 ###################################

none

map04742################################### CC42 ###################################

Taste transduction

1.519################################### CC31 ###################################

map00910

Nitrogen metabolism

18.713

map04260

Cardiac muscle contraction

8.205

map04964

Proximal tubule bicarbonate reclamation

1.512

map04010

MAPK signaling pathway

5.454################################### CC43 ###################################

map04020

Calcium signaling pathway

2.306

map04010

MAPK signaling pathway

8.524

map04742

Taste transduction

2.096

map04020

Calcium signaling pathway

8.428################################### CC32 ###################################

map04260

Cardiac muscle contraction

5.193

none

map04727

GABAergic synapse

2.102################################### CC33 ###################################

map04725

Cholinergic synapse

1.764

map04260

Cardiac muscle contraction

6.204################################### CC44 ###################################

map04010

MAPK signaling pathway

3.174

map04010

MAPK signaling pathway

8.155

map04260

Cardiac muscle contraction

7.576

map04740

Olfactory transduction

3.121

map04020

Calcium signaling pathway

5.323

map04744

Phototransduction

2.273################################### CC45 ###################################

map04020

Calcium signaling pathway

2.01

map04260

Cardiac muscle contraction

14.183

map04114

Oocyte meiosis

1.834

map04010

MAPK signaling pathway

11.368map04070

Phosphatidylinositol signaling system

1.381

map04020

Calcium signaling pathway

4.803################################### CC57 ###################################

map04725

Cholinergic synapse

3.539

map00590

Arachidonic acid metabolism

2.688

map04727

GABAergic synapse

1.532

map04970

Salivary secretion

2.028################################### CC46 ###################################################################### CC58 ###################################

map00590

map04080

Arachidonic acid metabolism

9.47

Neuroactive ligand-receptor interaction

9.148################################### CC47 ###################################################################### CC59 ###################################

map04010

MAPK signaling pathway

5.109

none

map04260

Cardiac muscle contraction

4.932################################### CC60 ###################################

map04020

Calcium signaling pathway

2.079

none

map04728

Dopaminergic synapse

1.945################################### CC61 ###################################

map04270

Vascular smooth muscle contraction

1.327

none

################################### CC48 ###################################################################### CC62 ###################################

map04080

Neuroactive ligand-receptor interaction

6.679

map04060

map04725

Cholinergic synapse

1.879################################### CC63 ###################################

map04970

Salivary secretion

Cytokine-cytokine receptor interaction

2.688

1.536

map04728

Dopaminergic synapse

1.546################################### CC49 ###################################

map03040

Spliceosome

1.459

none

################################### CC64 ###################################################################### CC50 ###################################

map04145

Phagosome

3.087

map04728

map04540

Gap junction

2.469

Dopaminergic synapse

1.818################################### CC51 ###################################################################### CC65 ###################################

map03040

1.439

map00120

Primary bile acid biosynthesis

7.444################################### CC52 ###################################

Spliceosome

map00140

Steroid hormone biosynthesis

3.843

map04728

Dopaminergic synapse

7.997

map00100

Steroid biosynthesis

1.867

map04010

MAPK signaling pathway

7.444################################### CC66 ###################################

map04260

Cardiac muscle contraction

7.263

map04727

GABAergic synapse

map04020

Calcium signaling pathway

6.515

map04080

Neuroactive ligand-receptor interaction

20.1
11.858################################### CC53 ###################################################################### CC67 ###################################

none

map03040################################### CC54 ###################################################################### CC68 ###################################

map04080

Neuroactive ligand-receptor interaction

4.59

map03040

map04728

Dopaminergic synapse

3.553################################### CC69 ###################################

Spliceosome
Spliceosome

1.556
1.482

################################### CC55 ###################################

none

map04728

Dopaminergic synapse

3.825################################### CC70 ###################################

map04080

Neuroactive ligand-receptor interaction

1.829

none

################################### CC56 ###################################################################### CC71 ###################################

map04080

map00590

Neuroactive ligand-receptor interaction

4.233

Arachidonic acid metabolism

1.854

################################### CC72 ###################################

Receptors and Channels: Voltage-gated cation channels

2.962

map04964

G Protein-Coupled Receptors: Biogenic amine

2.019################################### CC73 ###################################

Receptors and Channels: Rhodopsin family: amine receptors

2.019

none

Ion Channels: Epithelial sodium channel (SCNN)

1.795################################### CC74 ###################################

Ion Channels: Acid-sensing ion channel (ASIC)

1.542

map04920

Adipocytokine signaling pathway

2.918################################### CC2 ###################################

map04080

Neuroactive ligand-receptor interaction

1.484

Proximal tubule bicarbonate reclamation

1.512

Ion Channels: GABA-A

30.842################################### CC75 ###################################

Receptors and Channels: Cys-loop superfamily

23.47

map04727

GABAergic synapse

14.25################################### CC3 ###################################

map04260

Cardiac muscle contraction

5.777

G Protein-Coupled Receptors: Biogenic amine

map04010

MAPK signaling pathway

5.186

Receptors and Channels: Rhodopsin family: amine receptors

6.84

map04080

Neuroactive ligand-receptor interaction

4.318

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.048

map04020

Calcium signaling pathway

2.102

Ion Channels: Na+ channel, SCN beta

3.659

map04728

Dopaminergic synapse

1.534

Receptors and Channels: Epithelial and related Na+ channels

2.798################################### CC76 ###################################

Receptors and Channels: Voltage-gated cation channels

2.528

map04144

Endocytosis

2.523

Ion Channels: Epithelial sodium channel (SCNN)

1.691

map04970

Salivary secretion

2.234

Ion Channels: Acid-sensing ion channel (ASIC)

1.439

6.84

################################### CC77 ###################################################################### CC4 ###################################

none

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

12.728################################### CC78 ###################################G Protein-Coupled Receptors: Biogenic amine

11.256map04080

Neuroactive ligand-receptor interaction

5.325

Receptors and Channels: Rhodopsin family: amine receptors

11.256map04970

Salivary secretion

3.003

Receptors and Channels: Related to voltage-gated cation channels

10.354

map04728

Dopaminergic synapse

1.728

Receptors and Channels: Voltage-gated cation channels

8.798

map04020

Calcium signaling pathway

1.593

Ion Channels: Ca2+ channel, CACN gamma

4.177################################### CC79 ###################################

Ion Channels: Ca2+ channel, CACN beta

4.177

map04260

Cardiac muscle contraction

14.25

Ion Channels: Ryanodine receptor (RYR)

2.881

map04010

MAPK signaling pathway

9.083

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.589

map04020

Calcium signaling pathway

3.368

Ion Channels: IP3 receptor

1.589

map04742

Taste transduction

1.439################################### CC5 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
6.412
oxygen into the substrate (oxygenases).

################################### CC80 ###################################
map04810

Regulation of actin cytoskeleton

1.559

map04020

Calcium signaling pathway

1.393(B) KEGG BRITE terms enriched in 80 canonical componenets (CCs)
BRITE category: BRITE term

P-value (log)################################### CC1 ###################################
Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.339

Ion Channels: Na+ channel, SCN beta

3.811

Receptors and Channels: Epithelial and related Na+ channels

3.003

Ion Channels: Na+ channel, SCN alpha, NaV1.x

4.511

Ion Channels: Na+ channel, SCN beta

3.34

Receptors and Channels: Voltage-gated cation channels

3.196

Receptors and Channels: Epithelial and related Na+ channels

2.389

Ion Channels: Epithelial sodium channel (SCNN)

1.5################################### CC6 ###################################
Ion Channels: Na+ channel, SCN alpha, NaV1.x

6.102

Ion Channels: Na+ channel, SCN beta

4.223

Receptors and Channels: Voltage-gated cation channels

4.137

Receptors and Channels: Epithelial and related Na+ channels

3.539

Ion Channels: Epithelial sodium channel (SCNN)

2.037

Receptors and Channels: Voltage-gated cation channels

2.406

Ion Channels: Acid-sensing ion channel (ASIC)

1.795

G Protein-Coupled Receptors: Neuropeptide

2.143################################### CC7 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.864

Ion Channels: Neurotransmitter transporters

1.709

Ion Channels: Acid-sensing ion channel (ASIC)

1.61

Receptors and Channels: Related to neurotransmitter transporters

1.709

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.048################################### CC14 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
1.924
oxygen into the substrate (oxygenases).

Receptors and Channels: Voltage-gated cation channels

4.226################################### CC15 ###################################

Ion Channels: Na+ channel, SCN beta

3.659

none

Receptors and Channels: Epithelial and related Na+ channels

2.798################################### CC16 ###################################G Protein-Coupled Receptors: Biogenic amine

1.826

Receptors and Channels: Related to voltage-gated cation channels

12.498

Receptors and Channels: Rhodopsin family: amine receptors

1.826

Receptors and Channels: Voltage-gated cation channels

11.244

Ion Channels: Epithelial sodium channel (SCNN)

1.691

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

10.179Ion Channels: Acid-sensing ion channel (ASIC)

1.439

Ion Channels: Ca2+ channel, CACN gamma

5.017################################### CC9 ###################################

Ion Channels: Ca2+ channel, CACN beta

5.017

G Protein-Coupled Receptors: Biogenic amine

16.034

Ion Channels: Ryanodine receptor (RYR)

3.461

Receptors and Channels: Rhodopsin family: amine receptors

16.034

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.973

Ion Channels: Neurotransmitter transporters

2.196

Ion Channels: IP3 receptor

1.973

Receptors and Channels: Related to neurotransmitter transporters

2.196################################### CC17 ###################################G Protein-Coupled Receptors: Neuropeptide

1.926

G Protein-Coupled Receptors: Biogenic amine

9.717################################### CC10 ###################################

Receptors and Channels: Rhodopsin family: amine receptors

9.717

Ion Channels: Na+ channel, SCN beta

3.659

Ion Channels: Acetylcholine (nicotinic)

5.752

Ion Channels: Na+ channel, SCN alpha, NaV1.x

3.416

Receptors and Channels: Cys-loop superfamily

3.179

Receptors and Channels: Epithelial and related Na+ channels

2.798

Nuclear Receptors:

1.373

Receptors and Channels: Voltage-gated cation channels

2.528################################### CC18 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.691

Ion Channels: Na+ channel, SCN alpha, NaV1.x

6.33

Ion Channels: Acid-sensing ion channel (ASIC)

1.439

G Protein-Coupled Receptors: Biogenic amine

4.696################################### CC11 ###################################

Receptors and Channels: Rhodopsin family: amine receptors

4.696

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.436

Ion Channels: Na+ channel, SCN beta

3.382

Ion Channels: Na+ channel, SCN beta

3.868

Receptors and Channels: Voltage-gated cation channels

2.562

Receptors and Channels: Voltage-gated cation channels

3.113

Receptors and Channels: Epithelial and related Na+ channels

2.437

Receptors and Channels: Epithelial and related Na+ channels

3.08

Ion Channels: Epithelial sodium channel (SCNN)

1.527

Ion Channels: Epithelial sodium channel (SCNN)

1.83################################### CC19 ###################################

Ion Channels: Acid-sensing ion channel (ASIC)

1.577################################### CC8 ###################################

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.808################################### CC12 ###################################

Ion Channels: Na+ channel, SCN beta

4.076

Ion Channels: Acetylcholine (nicotinic)

9.975

Receptors and Channels: Voltage-gated cation channels

3.664

6.558

Receptors and Channels: Epithelial and related Na+ channels

3.334################################### CC13 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.951

Ion Channels: Na+ channel, SCN beta

3.933

Ion Channels: Acid-sensing ion channel (ASIC)

1.694

Ion Channels: Na+ channel, SCN alpha, NaV1.x

3.801################################### CC20 ###################################

Receptors and Channels: Epithelial and related Na+ channels

3.156

Ion Channels: Neurotransmitter transporters

Receptors and Channels: Cys-loop superfamily

2.542

Receptors and Channels: Related to neurotransmitter transporters

2.542################################### CC29 ###################################################################### CC21 ###################################

Ion Channels: Acetylcholine (nicotinic)

10.476

Peptidases: Family T1: proteasome family

29.111

Receptors and Channels: Cys-loop superfamily

6.474

Proteasome: Regulatory particles

16.241

G Protein-Coupled Receptors: Biogenic amine

3.248

Enzymes: Acting on peptide bonds (peptidases)

9.702

Receptors and Channels: Rhodopsin family: amine receptors

3.248################################### CC22 ###################################

Enzymes: Carbon-oxygen lyases

1.607

Ion Channels: Na+ channel, SCN beta

4.305################################### CC30 ###################################

Ion Channels: Na+ channel, SCN alpha, NaV1.x

4.305

Ion Channels: Na+ channel, SCN beta

4.076

Receptors and Channels: Epithelial and related Na+ channels

3.659

Ion Channels: Na+ channel, SCN alpha, NaV1.x

3.987

Receptors and Channels: Voltage-gated cation channels

3.311

Receptors and Channels: Voltage-gated cation channels

3.664

Ion Channels: Epithelial sodium channel (SCNN)

2.094

Receptors and Channels: Epithelial and related Na+ channels

3.334

Ion Channels: Acid-sensing ion channel (ASIC)

1.845

Ion Channels: Epithelial sodium channel (SCNN)

1.951################################### CC23 ###################################

Ion Channels: Acid-sensing ion channel (ASIC)

1.694

G Protein-Coupled Receptors: Biogenic amine

13.277################################### CC31 ###################################

Receptors and Channels: Rhodopsin family: amine receptors

13.277

Receptors and Channels: Related to voltage-gated cation channels

12.655################################### CC24 ###################################

Receptors and Channels: Voltage-gated cation channels

4.624

Receptors and Channels: Cys-loop superfamily

32.344

Ion Channels: Ryanodine receptor (RYR)

3.506

Ion Channels: GABA-A

22.569Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

3.059

Ion Channels: Acetylcholine (nicotinic)

8.811

Ion Channels: Ca2+ channel, CACN gamma

3.003

G Protein-Coupled Receptors: Biogenic amine

4.609

Ion Channels: Ca2+ channel, CACN beta

3.003

Receptors and Channels: Rhodopsin family: amine receptors

4.609

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

2.002################################### CC25 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
5.712
oxygen into the substrate (oxygenases).

Ion Channels: IP3 receptor

2.002

Ion Channels: Epithelial sodium channel (SCNN)

1.602

Ion Channels: Na+ channel, SCN alpha, NaV1.x

3.854

Transcription Factors: Zinc finger

11.242

Ion Channels: Na+ channel, SCN beta

2.981

Receptors and Channels: Subfamily 3: estrogen like

8.632

Receptors and Channels: Voltage-gated cation channels

2.657

Receptors and Channels: Subfamily 2: hepatocyte nuclear factor 4 like

3.388

Receptors and Channels: Epithelial and related Na+ channels

1.902

Nuclear Receptors:

3.273################################### CC26 ###################################

Nuclear Receptors:

2.769

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

15.584

G Protein-Coupled Receptors: Biogenic amine

2.274

Receptors and Channels: Voltage-gated cation channels

15.01

Receptors and Channels: Rhodopsin family: amine receptors

2.274

Receptors and Channels: Related to voltage-gated cation channels

6.341

Nuclear Receptors:

1.853

Ion Channels: Ca2+ channel, CACN gamma

5.131

Nuclear Receptors:

1.853

Ion Channels: Ca2+ channel, CACN beta

5.131################################### CC33 ###################################

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

2.029

Receptors and Channels: Related to voltage-gated cation channels

10.588Ion Channels: IP3 receptor

2.029

Receptors and Channels: Voltage-gated cation channels

10.447################################### CC27 ###################################

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.339

none

Ion Channels: Ryanodine receptor (RYR)

2.958################################### CC28 ###################################

Ion Channels: Na+ channel, SCN beta

2.958

Ion Channels: GABA-A

26.176

Ion Channels: Ca2+ channel, CACN gamma

2.426

Receptors and Channels: Cys-loop superfamily

18.853Ion Channels: Ca2+ channel, CACN beta

2.426################################### CC32 ###################################

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

2.303

Receptors and Channels: Rhodopsin family: amine receptors

8.43

Receptors and Channels: Epithelial and related Na+ channels

1.866

Ion Channels: Ca2+ channel, CACN gamma

4.207

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.635

Ion Channels: Ca2+ channel, CACN beta

4.207

Ion Channels: IP3 receptor

1.635

Ion Channels: Ryanodine receptor (RYR)

2.907################################### CC34 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
19.353oxygen into the substrate (oxygenases).

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.603

Ion Channels: IP3 receptor

1.603

Cytochrome P450: CYP8 family

2.36

Nuclear Receptors:

2.186

Cytochrome P450: CYP7 family

2.36

Receptors and Channels: Subfamily 3: estrogen like

1.618

Cytochrome P450: CYP4 family

2.36################################### CC41 ###################################

Cytochrome P450: CYP27 family

2.36################################### CC40 ###################################

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.808################################### CC35 ###################################

Ion Channels: Na+ channel, SCN beta

4.076

Ion Channels: GABA-A

30.842

Receptors and Channels: Voltage-gated cation channels

3.664

Receptors and Channels: Cys-loop superfamily

23.47

Receptors and Channels: Epithelial and related Na+ channels

3.334################################### CC36 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.951

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

7.94

Ion Channels: Acid-sensing ion channel (ASIC)

1.694

Receptors and Channels: Voltage-gated cation channels

7.291

Receptors and Channels: Related to voltage-gated cation channels

6.061################################### CC43 ###################################

Ion Channels: Ca2+ channel, CACN gamma

2.928

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

12.415

Ion Channels: Ca2+ channel, CACN beta

2.928

Receptors and Channels: Voltage-gated cation channels

7.592

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.951

G Protein-Coupled Receptors: Biogenic amine

2.443

Ion Channels: IP3 receptor

1.951

Receptors and Channels: Rhodopsin family: amine receptors

2.443################################### CC37 ###################################

Ion Channels: Ca2+ channel, CACN beta

1.742

Ion Channels: GABA-A

25.251################################### CC44 ###################################

Receptors and Channels: Cys-loop superfamily

17.927

Receptors and Channels: Related to voltage-gated cation channels

13.809G Protein-Coupled Receptors: Neuropeptide

3.299

Receptors and Channels: Voltage-gated cation channels

7.123

Receptors and Channels: Rhodopsin family: peptide receptors

1.883

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

6.929################################### CC38 ###################################

Ion Channels: Ryanodine receptor (RYR)

3.811

Transcription Factors: Zinc finger

15.466

Ion Channels: Ca2+ channel, CACN gamma

3.286

Receptors and Channels: Subfamily 3: estrogen like

12.472

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

2.194

Nuclear Receptors:

5.339

Ion Channels: IP3 receptor

2.194

Receptors and Channels: Subfamily 2: hepatocyte nuclear factor 4 like

3.973

Ion Channels: Ca2+ channel, CACN beta

1.542

Nuclear Receptors:

3.697################################### CC45 ###################################

Nuclear Receptors:

2.123

Receptors and Channels: Voltage-gated cation channels

9.747

Nuclear Receptors:

2.123

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

9.588################################### CC39 ###################################

Receptors and Channels: Related to voltage-gated cation channels

7.523

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

10.438Ion Channels: Ca2+ channel, CACN gamma

4.733

Receptors and Channels: Related to voltage-gated cation channels

10.438Ion Channels: Ca2+ channel, CACN beta

4.733

Receptors and Channels: Voltage-gated cation channels

10.045

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.853

Ion Channels: IP3 receptor

1.853################################### CC42 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of oxygen into
6.558
the substrate (oxygenases). The oxygen incorporated
need
not be derivedlyases
from O2
Enzymes:
Carbon-oxygen
20.614

G Protein-Coupled Receptors: Biogenic amine

8.43

G Protein-Coupled Receptors: Neuropeptide

Ion Channels: Ca2+ channel, CACN gamma

2.736################################### CC46 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
8.62
oxygen into the substrate (oxygenases).

1.528

Ion Channels: Ca2+ channel, CACN beta

2.736

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.83

Ion Channels: IP3 receptor

1.83################################### CC47 ###################################G Protein-Coupled Receptors: Biogenic amine

1.311

Receptors and Channels: Related to voltage-gated cation channels

6.061

Receptors and Channels: Rhodopsin family: amine receptors

1.311

Receptors and Channels: Voltage-gated cation channels

5.208################################### CC53 ###################################

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

4.376

none

Ion Channels: Ca2+ channel, CACN gamma

2.928################################### CC54 ###################################

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.951

G Protein-Coupled Receptors: Biogenic amine

5.048

Ion Channels: IP3 receptor

1.951

Receptors and Channels: Rhodopsin family: amine receptors

5.048################################### CC48 ###################################G Protein-Coupled Receptors: Neuropeptide

3.062

Ion Channels: Acetylcholine (nicotinic)

11.688

Receptors and Channels: Rhodopsin family: peptide receptors

2.003

Receptors and Channels: Cys-loop superfamily

7.648################################### CC55 ###################################G Protein-Coupled Receptors: Biogenic amine

2.548

G Protein-Coupled Receptors: Biogenic amine

3.149

Receptors and Channels: Rhodopsin family: amine receptors

2.548

Receptors and Channels: Rhodopsin family: amine receptors

3.149################################### CC49 ###################################

Ion Channels: Neurotransmitter transporters

2.308

Ion Channels: Na+ channel, SCN alpha, NaV1.x

6.929

Receptors and Channels: Related to neurotransmitter transporters

2.308

Ion Channels: Na+ channel, SCN beta

3.659################################### CC56 ###################################

Receptors and Channels: Voltage-gated cation channels

3.334

G Protein-Coupled Receptors: Biogenic amine

6.321

Receptors and Channels: Epithelial and related Na+ channels

2.798

Receptors and Channels: Rhodopsin family: amine receptors

6.321

Ion Channels: Epithelial sodium channel (SCNN)

1.691

Nuclear Receptors:

1.653

Ion Channels: Acid-sensing ion channel (ASIC)

1.439

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.436################################### CC57 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
3.729
oxygen into the substrate (oxygenases).

Ion Channels: Na+ channel, SCN beta

3.868

G Protein-Coupled Receptors: Biogenic amine

3.077

G Protein-Coupled Receptors: Biogenic amine

3.248

Receptors and Channels: Rhodopsin family: amine receptors

3.077

Receptors and Channels: Rhodopsin family: amine receptors

3.248

Ion Channels: Neurotransmitter transporters

1.466

Receptors and Channels: Voltage-gated cation channels

3.113

Receptors and Channels: Related to neurotransmitter transporters

1.466

Receptors and Channels: Epithelial and related Na+ channels

3.08################################### CC58 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.83

G Protein-Coupled Receptors: Biogenic amine

4.254

Ion Channels: Acid-sensing ion channel (ASIC)

1.577

Receptors and Channels: Rhodopsin family: amine receptors

4.254################################### CC51 ###################################

Ion Channels: Glycine

2.699

Chaperones and folding catalysts: Peptidyl prolyl isomerase

41.316

G Protein-Coupled Receptors: Neuropeptide

2.654

Enzymes: cis-trans-Isomerases

41.316

Receptors and Channels: Cys-loop superfamily

2.496

Spliceosome: Other components

4.605

Ion Channels: Epithelial sodium channel (SCNN)

1.406################################### CC50 ###################################################################### CC52 ###################################################################### CC59 ###################################

Receptors and Channels: Related to voltage-gated cation channels

11.66

G Protein-Coupled Receptors: Biogenic amine

1.439

Receptors and Channels: Voltage-gated cation channels

8.348

Receptors and Channels: Rhodopsin family: amine receptors

1.439

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

7.43################################### CC60 ###################################

Ion Channels: Ryanodine receptor (RYR)

3.248

Ion Channels: Na+ channel, SCN beta

4.223

Ion Channels: Na+ channel, SCN alpha, NaV1.x

4.201

Chaperones and folding catalysts: Peptidyl prolyl isomerase

44.339Receptors and Channels: Epithelial and related Na+ channels

3.539

Enzymes: cis-trans-Isomerases

44.339Receptors and Channels: Voltage-gated cation channels

3.104

Spliceosome: Other components

4.894

Ion Channels: Epithelial sodium channel (SCNN)

2.037################################### CC68 ###################################

Ion Channels: Acid-sensing ion channel (ASIC)

1.795

Chaperones and folding catalysts: Peptidyl prolyl isomerase

42.074################################### CC61 ###################################

Enzymes: cis-trans-Isomerases

42.074

Ion Channels: Na+ channel, SCN alpha, NaV1.x

7.16

Spliceosome: Other components

4.689

Receptors and Channels: Voltage-gated cation channels

4.615################################### CC69 ###################################

Ion Channels: Na+ channel, SCN beta

3.753

Receptors and Channels: Voltage-gated cation channels

7.123

Receptors and Channels: Epithelial and related Na+ channels

2.938

Ion Channels: Na+ channel, SCN alpha, NaV1.x

5.339

Ion Channels: Epithelial sodium channel (SCNN)

1.755

Ion Channels: Na+ channel, SCN beta

3.811

Ion Channels: Acid-sensing ion channel (ASIC)

1.504

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

3.441################################### CC62 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
4.867
oxygen into the substrate (oxygenases).

Receptors and Channels: Epithelial and related Na+ channels

3.003

Ion Channels: Epithelial sodium channel (SCNN)

1.795

Ion Channels: Acid-sensing ion channel (ASIC)

1.542

GTP-Binding Proteins: Rho Family

2.194################################### CC70 ###################################

Protein Kinases: PDGFR family

1.346

Enzyme-linked Receptors, Cytokine Receptors: RTK class III (PDGF receptor family)5.436################################### CC63 ###################################

Receptors and Channels: Subfamily 3: estrogen like

4.412

Chaperones and folding catalysts: Peptidyl prolyl isomerase

41.706

Nuclear Receptors:

2.452

Enzymes: cis-trans-Isomerases

41.706

G Protein-Coupled Receptors: Neuropeptide

2.426

Spliceosome: Other components

4.64

Transcription Factors: Zinc finger

2.426

G Protein-Coupled Receptors: Biogenic amine

2.161

Nuclear Receptors:

1.795

Receptors and Channels: Rhodopsin family: amine receptors

2.161

Protein Kinases: PDGFR family

1.603################################### CC64 ###################################

Receptors and Channels: Rhodopsin family: peptide receptors

1.406

Cytoskeleton proteins: Microtubules################################### CC71 ###################################

9.975

Enzyme-linked Receptors, Cytokine Receptors: RTK class III (PDGF receptor family)5.339

Ion Channels: Na+ channel, SCN alpha, NaV1.x
Enzymes: Acting on single donors with O2 as oxidant and incorporation ofoxygen into the substrate (oxygenases).

4.309
4.076

################################### CC65 ###################################
Enzymes: Acting on single donors with O2 as oxidant and incorporation of
15.413oxygen into the substrate (oxygenases).

Ion Channels: Na+ channel, SCN beta

3.248

Receptors and Channels: Voltage-gated cation channels

1.543

G Protein-Coupled Receptors: Neuropeptide

1.494

G Protein-Coupled Receptors: Biogenic amine

2.736################################### CC72 ###################################

Receptors and Channels: Rhodopsin family: amine receptors

2.736

none

Cytochrome P450: CYP8 family

2.029################################### CC73 ###################################

Cytochrome P450: CYP7 family

2.029

Ion Channels: Na+ channel, SCN alpha, NaV1.x

Cytochrome P450: CYP4 family

2.029

Ion Channels: Na+ channel, SCN beta

Cytochrome P450: CYP27 family

2.029

Receptors and Channels: Voltage-gated cation channels

3.459

Enzymes: Carbon-oxygen lyases

1.311

Protein Kinases: PDGFR family

1.559

Enzymes: Other isomerases

1.406

5.68
4

Receptors and Channels: Epithelial and related Na+ channels

3.248################################### CC66 ###################################

Ion Channels: Epithelial sodium channel (SCNN)

1.905

Ion Channels: GABA-A

30.842

Ion Channels: Acid-sensing ion channel (ASIC)

1.653

Receptors and Channels: Cys-loop superfamily

23.47################################### CC74 ###################################################################### CC67 ###################################

Transcription Factors: Zinc finger

7.392

Ion Channels: IP3 receptor

Nuclear Receptors:

3.461

Receptors and Channels: Subfamily 3: estrogen like

3.388

G Protein-Coupled Receptors: Neuropeptide

3.003################################### CC80 ###################################
Enzyme-linked Receptors, Cytokine Receptors: RTK class III (PDGF
6.929
receptor family)

Nuclear Receptors:

2.963

Ion Channels: Acetylcholine (nicotinic)

2.688

Receptors and Channels: Subfamily 2: hepatocyte nuclear factor 4 like

2.145

Receptors and Channels: Rhodopsin family: peptide receptors

1.598

Nuclear Receptors:

1.577################################### CC75 ###################################
Ion Channels: GABA-A

16.504

Receptors and Channels: Cys-loop superfamily

10.438

Receptors and Channels: Related to voltage-gated cation channels

10.184

Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

6.324

Receptors and Channels: Voltage-gated cation channels

4.867

Ion Channels: Ryanodine receptor (RYR)

2.827

Ion Channels: Ca2+ channel, CACN gamma

2.305

Ion Channels: Ca2+ channel, CACN beta

2.305

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.559

Ion Channels: IP3 receptor

1.559

Ion Channels: Neurotransmitter transporters

1.355

Receptors and Channels: Related to neurotransmitter transporters

1.355################################### CC76 ###################################G Protein-Coupled Receptors: Biogenic amine

3.136

Receptors and Channels: Rhodopsin family: amine receptors

3.136################################### CC77 ###################################none################################### CC78 ###################################G Protein-Coupled Receptors: Biogenic amine

14.671

Receptors and Channels: Rhodopsin family: amine receptors

14.671################################### CC79 ###################################
Receptors and Channels: Voltage-gated cation channels

15.526

Receptors and Channels: Related to voltage-gated cation channels

10.678Ion Channels: Ca2+ channel, CACN alpha-1, CaVx.x

8.607

Ion Channels: Ca2+ channel, CACN gamma

4.305

Ion Channels: Ca2+ channel, CACN beta

4.305

Ion Channels: Ryanodine receptor (RYR)

2.981

Ion Channels: Na+ channel, SCN beta

2.981

Ion Channels: Na+ channel, SCN alpha, NaV1.x

2.52

Receptors and Channels: Epithelial and related Na+ channels

1.902

Ion Channels: Transient receptor potential family, TRPP (Polycystin)

1.653

1.653

G Protein-Coupled Receptors: Biogenic amine

2.325

Receptors and Channels: Rhodopsin family: amine receptors

2.325

Protein Kinases: PDGFR family

2.194

Enzymes: Other isomerases

2.037