助教

鍬野哲

東京⼯業⼤学 理学院化学系〒152-8551 東京都⽬⿊区⼤岡⼭ 2-12-1-H91
E-mail: kuwano@chem.titech.ac.jp【略歴】
2009 年 3 ⽉

崇城⼤学 薬学部 薬学科卒業

2011 年 3 ⽉

京都⼤学⼤学院 薬学研究科 創薬科学専攻修⼠課程修了

2014 年 3 ⽉

京都⼤学⼤学院 薬学研究科 創薬科学専攻博⼠後期課程修了

2014 年 4 ⽉

第⼀薬科⼤学 薬学部 育薬研究センター

助教

2015 年 11 ⽉

千葉⼤学⼤学院 理学研究科 化学コース特任助教2017 年 4 ⽉

千葉⼤学⼤学院 理学研究院 化学研究部⾨特任助教2020 年 5 ⽉

東京⼯業⼤学 理学院 化学系

助教

【受賞】
2013 年 3 ⽉

⽇本薬学会第 133 年会（横浜）優秀発表賞

2014 年 4 ⽉

平成 25 年度笹川科学研究奨励賞

2017 年 12 ⽉

2017 年度有機合成化学協会 東レ研究企画賞【発表論⽂】
1.

S. Kuwano, E. Takahashi, J. Kikushima, S. Sase, K. Goto*“Efficient Oxyselenation and Aminoselenation Utilizing a Selenenyl Iodide Based on the Characteristic
Thermodynamics of Its Reaction with Olefins”
New J. Chem. 2023, DOI: 10.1039/D2NJ06346H.

2.

K. Goto,* T. Sano, R. Masuda, S. Otaka, R. Kimura, S. Sase, S. Kuwano“Stable Cysteine Sulfenic Acid: Synthesis by Direct Oxidation of a Thiol, Crystallographic Analysis, andElucidation of Reactivities”
Phosphorus, Sulfur, Silicon, Relat. Elem. 2023, DOI: 10.1080/10426507.2023.2195650.

3.

T. Inokuma, K. Iritani, Y. Takahara, C. Sun, Y. Yamaoka, S. Kuwano, K. Yamada,*“Remote electronic effect on the N-heterocyclic carbene-catalyzed asymmetric intramolecular Stetter
reaction and structural revision of products”
Chem. Commun. 2023, DOI: 10.1039/d3cc00693j.

4.

K. Yamada,* A. Yamauchi, T. Fujiwara, K. Hashimoto, Y. Wang, S. Kuwano, T. Inokuma“Kinetic Resolution of alpha-Hydroxyamide via N-Heterocyclic Carbene-Catalyzed Acylation”
Asian J. Org. Chem. 2022, 11, e202200452.

5.

R. Masuda, S. Kuwano, S. Sase, M. Bortoli, A. Madabeni, L. Orian, K. Goto*“Model Study on the Catalytic Cycle of Glutathione Peroxidase Utilizing Selenocysteine-Containing
Tripeptides: Elucidation of the Protective Bypass Mechanism Involving Selenocysteine Selenenic Acids”
Bull. Chem. Soc. Jpn. 2022, 95, 1360–1379.

6.

Y. Wang, A. Yamauchi, K. Hashimoto, T. Fujiwara, T. Inokuma, Y. Mitani, K. Ute, S. Kuwano, Y.
Yamaoka, K. Takasu,* K. Yamada.*“Enhanced Molecular Recognition through Substrate–Additive Complex Formation in N-HeterocyclicCarbene-Catalyzed Kinetic Resolution of α-Hydroxythioamides”
ACS Catal. 2022, 12, 6100‒6107.

7.

E. Ogino, S. Kuwano, T. Arai*“Chiral Aminomethylbinaphthol-catalyzed Diastereo- and Enantioselective Epoxidation of TrisubstitutedAcrylonitriles”
Adv. Synth. Catal. 2022, 364, 1503‒1506.

8.

S. Kuwano, E. Takahashi, K. Ebisawa, Y. Ishikawa, S. Sase, K. Goto*“Oxyselenation and Aminoselenation of Alkenes Utilizing an Isolable Selenenyl Iodide”Mendeleev Commun. 2022, 32, 80‒82.

9.

R. Masuda, S. Kuwano, K. Goto*“Late-Stage Functionalization of the Periphery of Oligophenylene Dendrimers with Various Arene Units
via Fourfold C-H Borylation”
J. Org. Chem. 2021, 86, 14433‒14443.
(Selected as a "Supplementary Cover")10. S. Kuwano, E. Ogino, T. Arai*“Enantio- and Diastereoselective Double Mannich Reaction of Malononitrile with N-Boc Imines Using
Quinine-derived Bifunctional Organoiodine Catalyst”
Org. Biomol. Chem. 2021, 19, 6969‒6973.

11. Y. Nishida, T. Suzuki, Y. Takagi, E. Amma, R. Tajima, S. Kuwano, T. Arai*“A Hypervalent Cyclic Dibenzoiodolium Salt as a Halogen-Bond-Donor Catalyst for the [4+2]Cycloaddition of 2-Alkenylindoles.”
ChemPlusChem 2021, 86, 741‒744.

12. E. Ogino, A. Nakamura, S. Kuwano, T. Arai*“Chiral C2-Symmetric Aminomethylbinaphthol as Synergistic Catalyst for Asymmetric Epoxidation of
Alkylidenemalononitriles: Easy Access to Chiral Spirooxindoles”
Org. Lett. 2021, 23, 1980‒1985.
(Selected as a "Cover picture")

13. J. Ma, T. Suzuki, S. Kuwano, T. Arai*“Catalytic Asymmetric Chlorination of alpha-Ketoesters Using N-PFB-PyBidine-Zn(OAc)2”
Catalysts 2020, 10, 1177‒1185.

14. T. Suzuki, S. Kuwano, T. Arai*“Non-bonding Electron Pair versus π-Electrons in Solution Phase Halogen Bond Catalysis: Povarov
Reaction of 2-Vinylindoles and Imines”
Adv. Synth. Catal. 2020, 362, 3208‒3212.

15. A. Nakamura, S. Kuwano, J. Sun, K. Araseki, E. Ogino, T. Arai*“Practically Useful Chiral Dinuclear Benzyliminobinaphthoxy-Pd Catalyst for Asymmetric Mannich
Reaction of Aldimines and Isatin-derived Ketimines with Alkylmalononitriles”
Adv. Synth. Catal. 2020, 362, 3105‒3109.

16. S. Kuwano, Y. Nishida, T. Suzuki, T. Arai*“Catalytic Asymmetric Mannich-Type Reaction of Malononitrile with N-Boc α-Ketiminoesters Using
Chiral Organic Base Catalyst with Halogen Bond Donor Functionality”
Adv. Synth. Catal. 2020, 362, 1674‒1678.
(featured by Synfacts 2020, 16, 0736.)

17. S. Kuwano,* Y. Hosaka, T. Arai*“Chiral Benzazaborole-Catalyzed Regioselective Sulfonylation of Unprotected Carbohydrate Derivatives”
Chem. Eur. J. 2019, 25, 12920‒12923.

18. T. Arai,* Y. Iimori, M. Shirasugi, R. Shinohara, Y. Takagi, T. Suzuki, J. Ma, S. Kuwano, H. Masu
“Bis(imidazolidine)pyridine-CoCl2: A Novel, Catalytically Active Neutral Complex for AsymmetricMichael Reaction of 1,3-Carbonyl Compounds with Nitroalkenes”
Adv. Synth. Catal. 2019, 361, 3704‒3711.

19. S. Kuwano, T. Suzuki, M. Yamanaka, R. Tsutsumi, T. Arai*“Catalysis Based on C−I···π Halogen Bonds: Electrophilic Activation of 2-Alkenylindoles by Cationic
Halogen-Bond-Donors for [4+2] Cycloadditions”
Angew. Chem. Int. Ed. 2019, 58, 10220‒10224.

20. S. Kuwano,* Y. Hosaka, T. Arai*“Chiral Benzazaborole as Catalyst for Enantioselective Sulfonylation of cis-1,2-Diols”
Org. Biomol. Chem. 2019, 17, 4475‒4482.
(Selected as a "Inside Front Cover")21. S. Kuwano, T. Suzuki, Y. Hosaka, T. Arai*“Chiral Organic Base Catalyst with Halogen Bonding Donor Functionality: Asymmetric Mannich
Reaction of Malononitrile with N-Boc Aldimines and Ketimines”
Chem. Commun. 2018, 54, 3847‒3850.
22. S. Kuwano, T. Suzuki, T. Arai*“2-Iodoimidazolinium Salt-catalyzed Friedel–Crafts Reaction: Synthesis of Bis(indolyl)methane
Alkaloids”
Heterocycles, 2018, 97, 163‒169.

23. T. Arai,* T. Tosaka, S. Kuwano“Catalytic Asymmetric Mannich Reaction of Isatin-derived N-Boc Imines with Malononitrile byBis(imidazolidine)-derived Pincer Rh Complex”
ChemistrySelect. 2017, 2, 7368‒7371.

24. B. Kang, Y. Wang, S. Kuwano, Y. Yamaoka, K. Takasu,* K. Yamada*“Site-selective Benzoin-type Cyclization of Unsymmetrical Dialdoses Catalyzed by N-HeterocyclicCarbenes for Divergent Cyclitol Synthesis”
Chem. Commun. 2017, 53, 4469‒4472.

25. T. Arai,* T. Suzuki, T. Inoue, S. Kuwano“Chiral Bis(imidazolidine)iodobenzene (I-Bidine) Organocatalyst for Thiochromane Synthesis Using an
Asymmetric Michael/Henry Reaction”
Synlett 2017, 28, 122‒127.

26. S. Kuwano,* T. Masuda, K.Yamaguchi, T. Arai
“N-Heterocyclic Carbene-promoted [3+2] Cycloaddition of Allenyl Sulfone and Arylidenemalononitriles”
Heterocycles, 2017, 95, 232‒242.

27. Y. Wang, R. Oriez, S. Kuwano, Y. Yamaoka, K. Takasu, K. Yamada*“Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide
with N-Heterocyclic Carbene”
J. Org. Chem. 2016, 81, 2652‒2664.

28. S. Kuwano,* T. Masuda“N-Heterocyclic Carbene Catalyzed Monoacylation of Vicinal Diols”
Synthesis 2016, 48, 573‒578.

29. T. Arai,* C. Tokumitsu, T. Miyazaki, S. Kuwano, A. Awata“Catalytic Asymmetric [3+2]-Cycloaddition for Stereodivergent Synthesis of Chiral Indolyl-pyrrolidines”
Org. Biomol. Chem. 2016, 14, 1831‒1839.

30. B. Kang, T. Sutou, Y. Wang, S. Kuwano, Y. Yamaoka, K. Takasu,* K. Yamada*“N-Heterocyclic Carbene-Catalyzed Benzoin Strategy for Divergent Synthesis of Cyclitol Derivatives
from Alditols”
Adv. Synth. Catal. 2015, 357, 131‒147.

31. S. Kuwano, S. Harada, B. Kang, R. Oriez, Y. Yamaoka, K. Takasu,* K. Yamada*“Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Cocatalyst in Chiral N-HeterocyclicCarbene-Catalyzed Asymmetric Acylation of Secondary Alcohols”
J. Am. Chem. Soc. 2013, 135, 11485‒11488.

32. S. Harada, S. Kuwano, Y. Yamaoka, K. Yamada,* K. Takasu*“Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids”
Angew. Chem. Int. Ed. 2013, 52, 10227‒10230.
(featured by Synfacts 2013, 9, 1236.)

33. S. Kuwano, S. Harada, R. Oriez, K. Yamada*“Chemoselective Conversion of α-Unbranched Aldehyde to Amide, Ester, and Carboxylic Acids by NHCCatalysis”
Chem. Commun. 2012, 48, 145‒147.