Loss of butyrate-induced apoptosis in human hepatoma cell lines HCC-M and HCC-T
having substantial Bcl-2 expression. Hepatology. 1998;27(5):1233-40. Hidetsugu Saito,Hirotoshi Ebinuma, Masahiko Takahashi, Fumihiko Kaneko, Kanji Wakabayashi,
Mitsuyasu Nakamura, Hiromasa Ishii.
Antisense oligodeoxynucleotide against c-myc mRNA induces diffeentiation of humanhepatocellular carcinoma cells. Int. J. Oncology. 1999;15:991-999. Ebinuma Hirotoshi,Saito Hidetsugu, Saito Yoshimasa, Wakabayashi Kanji, Nakamura Mitsuyasu, Kurose
Iwao, Ishii Hiromasa
Bcl-2 related proteins are dramatically induced at the early stage of differentiation inhuman liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic
role during this period. Oncology Reports.2000;7(2):285-288. Wakbayashi Kanji, Saito
Hidetsugu, Ebinuma Hirotoshi, Saito Yoshimasa, Takagi Tamako, Nakamura
Mitsuyasu, Umezawa Akihiro, Hata Junichi, Ishii Hiromasa
Reduction of telomerase activity in human liver cancer cells by a histone deacetylase
inhibitor. J Cell Physiol. 2001;187(3):392-401. Mitsuyasu Nakamura, Hidetsugu Saito ,Hirotoshi Ebinuma, Kanji Wakabayashi, Yoshimasa Saito, Tamako Takagi, Nobuhiro
Nakamoto, Hiromasa Ishii
Interferon-associated retinopathy in a uniform regimen of natural interferon-a therapy
for chronic hepatitis C Liver.2001;21(3):192-197 Saito Hidetsugu, Ebinuma Hirotoshi,
NagataHiroshi,InagakiYasutaka,

Nakamoto

Nobuhiro,

Saito

Yoshimasa,

Wakabayashi Kanji, Takagi Tamako, Nakamura Mitsuyasu, Katsura H, Oguchi Y, Ishii
Hiromasa
Effect of the molar ratio of branched-chain to aromatic amino acids on growth andalbumin mRNA expression of human liver cancer cell lines in a serum-free medium.
Nutr Cancer. 2001;39(1):126-131. Saito Yoshimasa, Saito Hidetsugu, Nakamura
Mitsuyasu, Wakabayashi Kanji, Takagi Tamako, Ebinuma Hirotoshi, Ishii HiromInterferon therapy for hepatocellular carcinoma patients with low HCV-RNA levels.
Hepatogastroenterology.2002;49(45):724-9. Miyaguchi S, Watanabe T, Takahashi H,Nakamura Mitsuyasu, Saito Hidetsugu, Ishii Hiromasa

The detection of IRF-1 promoter polymorphisms and their possible contribution to T
helper response in chronic hepatitis C. J Interferon Cytokine Res. 2002;22(6):693-700
Saito Hidetsugu, Tada Shinnichirou, Wakabayashi Kanji, Nakamoto Nobuhiro,Takahashi Masahiko, Nakamura Mitsuyasu, Ebinuma Hirotoshi, Ishii Hiromasa
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of theToll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA.2005;102(8):2992-7.
Kui Li , Eileen Foy , Josephine C. Ferreon , Mitsuyasu Nakamura , Allan C. M. Ferreon ,Masanori Ikeda , Stuart C. Ray , Michael Gale, Jr. , and Stanley M. Lemon
Association of pseudomembranous colitis with Henoch- Schonlein purpura. JGastroenterol.2005;40:641-5 TakehikoHayakawa,

Hiroyuki

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Nakamura, Shunsuke Komoto, Kazuo Maruta, Hidetoshi Shiozu, Haruhiko Ogata,
Yasushi Iwao, Hiromasa Ishii, Toshifumi Hibi
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B
RNA-dependent RNA polymerase. Proc Natl Acad Sci U S A.2005;102(50):18159-64Tsubasa Munakata, Mitsuyasu Nakamura, Yuqiong Liang, Kui Li, and Stanley M.
Lemon
Possible Molecular Mechanism of the Relationship Between NS5B Polymorphisms andEarly Clearance of Hepatitis C Virus During Interferon Plus Ribavirin Treatment
J.Med.Virol. 2008;80 (4):632-9.Mitsuyasu Nakamura, Hidetsugu Saito, Masanori Ikeda,
Shinichiro Tada, Naoki Kumagai Nobuyuki Kato, Kunitada Shimotohno, Toshifumi
Hibi
Advances in genomic research on hepatitis C virus with a useful tool , replicon system
Keio J Med.2008;57(2):75-83. Mitsuyasu Nakamura 、Hidetsugu Saito, Toshifumi Hibi
Omega-3 fatty acids exacerbateDSS-induced colitisthroughdecreased adiponectin incolonic

subepithelial

myofibroblasts.

InflammBowelDis

2008;14(10):1348-57.

Matsunaga H, Hokari R, Kurihara C, Okada Y, Takebayashi K, Okudaira K, Watanabe
C, Komoto S, Nakamura M, Tsuzuki Y, Kawaguchi A, Nagao S, Itoh K, Miura S.
Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescenceaccelerated mice (SAM)P1/Yit mice model. Clini Exp Immunol.2009;158(3)325-33

Matsunaga H, Hokari R, Kurihara C, Okada Y, Takebayashi K, Okudaira K, WatanabeC, Komoto S, Nakamura M, Tsuzuki Y, Kawaguchi A, Nagao S, Miura S.
Cilostazol, a specific PDE-3 inhibitor, ameliorates chronic ileitis via suppression ofinteraction

ofplatelets

withmonocytes. Am

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An antioxidant resveratrol significantly enhanced replication of hepatitis C virus. WorldJ Gastroenterol. 2010;16(2):184-92. Mitsuyasu Nakamura, Hidetsugu Saito, Masanori
Ikeda, Ryota Hokari, Nobuyuki Kato, Toshifumi Hibi, Soichiro Miura
Interferon-alpha increases monocyte migration via platelet-monocyte interaction inmurine intestinal microvessel Clini Exp immunol. 2010;162(1):156-62. Higashiyama M,Hokari R, Kurihara C, Ueda T, Nakamura M, Komoto S, Okada Y, Watanabe C,
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Increased expression of lipocain-type-prostaglandin Dsynthase in ulcerative colitis andexacerbating role in murine colitis. Am J Physiol Gastrointest Liver Physiol
2011,;300(3): G401-8. Hokari R, Kurihara C, Nagata N, AriakeK, OkadaY, WatanabeC,KomotoS, Nakamura M, KawaguchiA, NagaoS, Urade Y Miura S
Physiological stress exacerbates murine colitis by enhancing proinflammatorycytokine
expression that is dependent on IL-18. Am J Physiol Gsatrointest Liver Phyisiol 2011;
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G555-64.Matsunaga

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HozumiH,HigashiyamaM, OkadaY, WatanabeC, KomotoS, Nakamura M, Kawaguchi A., NagaoS,SekiyamaA, MiuraS,Effects of Astaxanthin on Intestinal Microflora in Mice Fed a High-fat Diet. Anti-AgingMedicine.2013;10(4):77-91.Yoshikazu Yonei, Masayuki Yagi, Mitsuyasu Nakamura,
Lanny Parengkuan, Mari Ogura, Toshio Taira, Sayori Asano , Hui-Hsiung Liu.