ポスター

Poster＊ 学生発表賞候補演題＊ Student Presentation Award Candidate Poster

1 日目（9 月 28 日（水））／Day 1（Sep. 28 Wed.）

蛋白質：構造／Protein: Structure
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珪藻 Thalassiosira pseudonana 由来ルビスコの構造解析及び新規ピレノイドタンパク質との相互作用解析
Structural study of RubisCO from diatom Thalassiosira pseudonana and its interaction withnovel pyrenoid proteins
Taiki Fukuzawa1, Rei Tohda1, Nawely Hermanus2, Natumi Morishima2, Ryosuke Okubo2,
Yoshinori Tsuji2, Akihiro Kawamoto1, Hideaki Tanaka1, Gerle Christogh1, Yusuke Matsuda2,
Genji Kurisu1 (1Institute for Protein Research, Osaka University, 2School of Biological andEnvironmental Sciences, Kwansei Gakuin University)
ヒト B 細胞抑制性共受容体 CD72 の構造解析
Structure analysis of human B cell inhibitory co-receptor CD72
Xibin Quan1, Nobutaka Numoto1, Takeshi Tsubata2,3, Nobutoshi Ito1 (1Dept. Struct. Biol., Med. Res.
Inst., Tokyo Med. Dent. Univ., 2Dept. Immunol., Med. Res. Inst., Tokyo Med. Dent. Univ., 3Sch. Dent.,
Nihon Univ.)
Generation of protein distance matrices and novel structures utilizing Generative Adversarial
Networks(GAN)
Taihei Yamaguchi (Grad. Sch. Agr. Life Sci., Univ. Tokyo)
ヒト由来電位依存性カリウムイオンチャネルのクライオ電子顕微鏡単粒子解析
Cryo-EM single particle analysis of a human voltage-gated potassium channel
Natsuko Sekido1, Tomona Iizuka2, Tomoyasu Aizawa2, Makoto Sasaki1, Haruhiko Fuwa3,
Mari Yotsu-Yamashita4, Keiichi Konoki4, Takeshi Yokoyama1, Yoshikazu Tanaka1 (1Grad. Sch. Life Sci.,
Tohoku Univ., 2Grad. Sch. Life Sci., Hokkaido Univ., 3Fac. Sci. & Eng., Chuo Univ., 4Grad. Sch. Agri
Sci., Tohoku Univ.)
電子線クライオトモグラフィーで可視化したスピロプラズマの細胞骨格リボン
Cytoskeletal ribbon of Spiroplasma revealed by cryo electron tomography
Yuya Sasajima1, Takayuki Kato2, Tomoko Miyata3, Akihiro Kawamoto2, Fumiaki Makino3,4,
Keiichi Namba3,5,6, Makoto Miyata1,7 (1Grad. Sch. Sci., Osaka Metropolitan Univ., 2IPR., Osaka Univ.,
3Grad. Sch. Front. Biosci., Osaka Univ., 4JEOL Ltd., 5BDR & SPring-8 Center, Riken, 6JEOLYOKOGUSHI Res. Alliance. Lab. Osaka Univ., 7OCARINA, Osaka Metropolitan Univ.)
左巻き βαβ モチーフをもつタンパク質のデノボデザインに向けて
Toward de novo design of left-handed βαβ-motif-containing proteins
Hiroto Murata, George Chikenji (Dept of Appl. Phys., Grad. Sch of Eng., Nagoya Univ.)
CRISPR-Cas7-11 の構造とエンジニアリングによる RNA ノックダウンツールへの応用
Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex
Kazuki Kato1, Wenyuan Zhou2, Sae Okazaki1, Yukari Isayama1, Tomohiro Nishizawa3,
Jonathan S. Gootenberg2, Omar O. Abudayyeh2, Hiroshi Nishimasu1 (1RCAST, Univ. Tokyo, 2MIBR, MIT,
3Grad. Sch. Med. Life Sci., Univ. Yokohama City)
疑似電子顕微鏡画像を機械学習することにより生体分子の同定手法を開発する
Deep learning of computer-generated electron microsopy images to identify biomolecules
Atsushi Matsumoto (Institute for Quantum Life Science, National Institutes for Quantum Science andTechnology)– S101 –1Pos009

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Time-resolved X-ray crystallography of E. coli MutT, a Nudix hydrolase
Teruya Nakamura1,2, Yuriko Yamagata1,3 (1Grad. Sch. of Pharmaceut. Sci., Kumamoto Univ., 2Priority
Organization for Innovation and Excellence, Kumamoto Univ., 3Shokei University and Shokei University
Junior College)
X 線自由電子レーザーを用いた単粒子解析における分子サイズ効果
Molecular size effect on the single-particle analysis using X-ray free electron laser
Miki Nakano1, Osamu Miyashita1, Florence Tama1,2,3 (1RIKEN Center for Computational Science,
2Grad. Sch. Sci., Nagoya Univ., 3ITbM, Nagoya Univ.)
クライオ電子顕微鏡を用いた繊毛軸糸ダイニンコンポーネント Calaxin の機能解析
Cryo-electron tomography revealed that Calaxin stabilizes the docking of outer arm dyneins
onto ciliary doublet microtubule in vertebrate
Hiroshi Yamaguchi, Masahide Kikkawa (Grad. Sch. Med., Univ. Tokyo)
スーパーフォールドを区別する構造ルールの探索:フェレドキシン構造とリバースフェレドキシ
ン構造の解析
The structural rule distinguishing a superfold: A case study of ferredoxin fold and the reverse
ferredoxin foldTakumi Nishina, George Chikenji (Dept of Appl. Phys., Grad. Sch. of Eng., Nagoya Univ.)
ネフローゼ症候群原因タンパク質 podocin の調製と結晶化
Preparation and crystallization of podocin, associated with nephrotic syndrome
Koki Ando1, Hideshi Yokoyama2 (1Grad. Sch. Pharm. Sci., Tokyo Univ. Sci., 2Fac. Pharm. Sci., Tokyo
Uni. Sci.)
TMD シミュレーションを用いたギャップ結合ファミリータンパク質のクローズ機構及び周囲の脂質分子の流動性の解析
Analysis on the closing mechanism of gap junction family proteins and fluidity of surrounding
lipid molecules by TMD simulation
Ikuma Kaneshiro1, Florence Tama1,2, Osamu Miyashita2 (1Grad. Sch. Sci., Univ. Nagoya, 2Kobe Inst.,
Riken)
レジリン蛋白質における自己組織化能の評価
Evaluation of Self-Assembling Ability in Resilin Proteins
Risa Tani1, Yoichi Yamazaki1, Kento Yonezawa1,2, Sachiko Toma1, Hironari Kamikubo1,2 (1NAIST, MS,
2NAIST, CDG)
代謝安定型作動薬と LysoPS 受容体 LPS1 の構造解析
Cryo-EM structure of LysoPS Receptor LPS1 in complex with Metabolically Stable Agonist
Ryo Kawahara1, Fumiya Sano1, Akiharu Uwamizu2, Luying Chen2, Tomohiko Ohwada2, Junken Aoki2,
Wataru Shihoya1, Osamu Nureki1 (1Grad. Sch. Sci., Univ. Tokyo, 2Grad. Sch. Pharm., Univ. Tokyo)
免疫受容体 LILRA2 の ANGPTL6 認識機構
Molecular mechanism of ANGPTL6 recognition by immune activation receptor LILRA2
Jiaqi Wang1, Atsushi Furukawa1,2, Rika Yamazaki1, Kouyuki Hirayasu3,4, Tsuyoshi Kadomatsu5,
Yuichi Oike5, Hisashi Arase3, Katsumi Maenaka1 (1Pharm. Sci. Hokkaido Univ., 2Pharm. Kanazawa
Univ., 3Res. Inst. Microbial Diseases, Osaka Univ., 4Adv. Preventive. Med. Sci. Res. Center., Kanazawa
Univ., 5Med., Kumamoto Univ.)
gREST 法による VHH 構造の効率的サンプリング
Enhanced Conformational Sampling of VHH by Generalized Replica-Exchange with Solute
TemperingRen Higashida, Kouhei Yamaguchi, Yasuhiro Matsunaga (Grad. Sch. Sci. Eng., Saitama Univ.)
毛髪ダメージに伴う毛髪繊維の変形とその分光学的解析
Deformation of hair fibers due to hair damage and its spectroscopic analysis
Kazuki Kobayashi, Atsushi Baba, Kazuyuki Suzuta, Len Ito (MILBON Co.,Ltd.)– S102 –1Pos020

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ミトコンドリア蛋白質搬入ゲート TOM 複合体の高速原子間力顕微鏡解析
High-speed atomic force microscopy analysis of the mitochondrial protein import gate TOM
complexYuhei Araiso1, Nanako Kobayashi1, Kana Kuzasa1, Hirotatsu Imai2, Aimi Makino2, Akihiro Inazu1,
Noriyuki Kodera2, Toshiya Endo3,4 (1Dept. of Clin. Lab. Sci., Div. of Health Sci., Kanazawa Univ., 2WPINanoLSI, Kanazawa Univ., 3Fac. of Life Sci., Kyoto Sangyo Univ., 4Inst. of Protein Dynamics, Kyoto
Sangyo Univ.)
カイコ storage protein の単粒子解析
Single particle analysis of silkworm storage proteinsShunsuke Kita, Yuki Anraku, Cong Tian, Katsumi Maenaka (Faculty of Pharmaceutical Sciences,
Hokkaido University)
狂犬病ウイルスの P 蛋白質が宿主の JAK-STAT 経路を阻害する分子機構の解明
Molecular dissection on how rabies virus P-protein inhibits JAK-STAT pathway of hostAoi Sugiyama1, Miku Minami1, Yukihiko Sugita2, Mika Hirose3, Shunsuke Kita1,4, Katsumi Maenaka1,4,
Min Yao1,5, Toyoyuki Ose1,5 (1Grad. Sch. Life Sci., Hokkaido Univ., 2Inst. Front. Life and Med. Sci.,
Kyoto Univ., 3Inst. Protein, Osaka Univ., 4Fac. Pharm. Sci., Hokkaido Univ., 5Fac. Adv. Life Sci.,
Hokkaido Univ.)
一分子蛍光測定を目指した SARS-CoV2 の N 蛋白質の精製及びラベル化
Purification and fluorophore labeling of SARS-CoV2 N protein aiming at single molecule
fluorescence measurements
Shun Endo1,2, Leo Suzuki1,2, Yuji Itoh1,2, Hiroyuki Oikawa1,2, Satoshi Takahashi1,2 (1Tohoku
Univ.Inst.,Tagenken, 2Grad.Sch.Sci.,Univ.Tohoku)
高分解能中性子構造解析によるペプチド結合の平面性の再検討
Revisiting the peptide bond planarity by high-resolution neutron structure
Yuya Hanazono1,2,3, Yu Hirano2,4, Kazuki Takeda1, Katsuhiro Kusaka5, Taro Tamada2, Kunio Miki1(1Grad. Sch. Sci., Kyoto Univ., 2Inst. Quant. Lif. Sci., QST, 3Med. Res. Inst., Tokyo Med. Dent. Univ.,
4PRESTO, JST, 5Front. Res. Cent. for Appl. Atom. Sci., Ibaraki Univ.)

蛋白質：構造機能相関／Protein: Structure & Function
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大腸菌由来 ribonuclease HI の金属イオン結合熱力学解析と活性との相関
Metal-ion binding and folding thermodynamics of Escherichia coli ribonuclease HI in correlation
with its activity
Yumi Kitagawa1, Zengwei Liao1, Kosuke Morikawa2, Masayuki Oda1 (1Grad. Sch. Life Environ. Sci.,
Kyoto Pref. Univ., 2Grad. Sch. Biostudies, Kyoto Univ.)
大規模な薬剤データセットにおける心筋イオンチャネル-薬剤間の結合自由エネルギー計算
Calculation of the binding free energies between cardiac ion channels and drugs on a large
data set
Tatsuki Negami, Tohru Terada (Grad. Sch. Agr. Life Sci., Univ. Tokyo)(2SBP-6) Automated Density Extraction of Isomorphous Difference map and Occupancyestimation for Conformer Fitting
Sriram Srinivasa Raghavan1, Florence Tama1,2,3, Osamu Miyashita1 (1RIKEN Center for
Computational Science, Kobe, Japan., 2Institute of Transformative Biomolecules (WPI-ITbM), Nagoya
University, Aichi, Japan., 3Department of Physics, Graduate School of Science, Nagoya University, Aichi,
Japan.)
HIV-1 の Nelfinavir 耐性プロテアーゼ D30N/N88D 変異体に対する動的残基間相互作用ネットワー
ク解析
Dynamic Residue Interaction Network Analysis of the Protease D30N/N88D Mutant Conferring
Nelfinavir Resistance in HIV-1
Ayaka Ojima, Norifumi Yamamoto (Chiba Tech)– S103 –1Pos029

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Elucidating the Mechanisms of the Bacterial Flagella ATPase Subcomplex
Thomas Stefan Davies1,2, Peter John Bond1, Alexander Krah1, Chrystala Constantinidou2 (1A*STAR
Singapore, 2University of Warwick)
Molecular dynamics study of phase behaviors of heat-resistant obscure proteins and their antiaggregation functions
Cheng Tan1, Ai Niitsu2, Yuji Sugita1,2,3 (1Computational Biophysics Research Team, RIKEN Center for
Computational Science, 2Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering
Research, 3Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics
Research)
インバース共溶媒分子動力学法による分子プローブ周辺アミノ酸残基環境の可視化
Inverse Mixed-Solvent Molecular Dynamics for Visualization of Amino Acid Residue Interaction
Profile of Molecular Probes
Keisuke Yanagisawa1, Ryunosuke Yoshino2,3, Genki Kudo4, Takatsugu Hirokawa2,3 (1Comput. Sci., Sch.
Comput., Tokyo Tech, 2Faculty Med., Univ. Tsukuba, 3TMRC, Univ. Tsukuba, 4Appl. Sci., Grad. Sch. Sci.
Tech., Univ. Tsukuba)
タイプ I インターフェロン経路を阻害する麻疹ウイルス V タンパク質の機能解析
Mechanistic analysis of type I interferon pathway inhibition by Measles virus V protein
Daiki Ito1, Madoka Kimoto1, Nanaka Goda1, Kiichi Hirohata2, Takahiro Maruno2, Susumu Uchiyama2,
Min Yao3, Toyoyuki Ose3 (1Grad. Sch. Life Sci., Univ. Hokkaido, 2Grad. Sch. Eng., Univ. Osaka, 3Grad.
Sch. Adv. Life Sci., Univ. Hokkaido)
SMN タンパク質のプロリン残基異性化による機能変化
Functional changes in SMN proteins by isomerization of proline residues
Saki Ohazama1, Shinichi Nakagawa2, Hiroshi Maita2 (1Graduate School of Life Science, Hokkaido
Univ., 2Faculty of Pharmaceutical Sciences, Hokkaido Univ.)
MD シミュレーションとクライオ電顕を用いた p97 の構造変化の研究
Conformational change of p97 by MD simulations and experimental data
Teppei Deguchi1, Florence Tama1,2,3, Osamu Miyashita1,3 (1Grad. Sch. Sci., Univ. Nagoya, 2ITbM,. Univ.
Nagoya, 3R-CCS., RIKEN)
ホソイトスギ由来パンアレルゲン、ポルカルシンの組換え発現と NMR 構造
Recombinant expression and NMR structural analysis of a pan-allergen, polcalcin from
European cypress
Peiwen Fan, Shaokai Zhao, Tomona Iizuka, Jingkang Zheng, Mitsuki Shibagaki, Tomoyasu Aizawa(Grad. Sch. Life Sci., Hokkaido Univ.)
STAT2 との相互作用に必要な麻疹ウイルス V 蛋白質最小領域の同定と相互作用特性
Characterization of the minimum region of measles virus V protein to interact with STAT2
Nanaka Goda1, Madoka Kimoto1, Daiki Ito1, Kaho Morita1, Hiroyuki Kumeta2, Min Yao2,
Toyoyuki Ose2 (1Grad. Sch. Life Sci., Univ. Hokkaido, 2Grad. Sch. Adv. Life Sci., Univ. Hokkaido)
ストレスファイバーにおけるアクチンサブユニットの張力依存的な構造状態
Tension-dependent structural state of actin subunits in stress fibers
Yuki Karan, Taro Q.P. Noguchi (National Institute of Technology, Miyakonojo College)
Structural dynamics and in silico design of pyrazolopyran-based inhibitors against Plasmodium
serine hydroxymethyltransferases
Pitchayathida Mee-udorn1, Bodee Nutho2, Romchalee Chootrakool3, Somchart Maenpuen4,
Ubolsree Leartsakulpanich5, Penchit Chitnumsub5, Thanyada Rungrotmongkol1,3 (1Program in
Bioinformatics and Computational Biology, Grad. Sch., Chulalongkorn Univ., Bangkok, Thailand,
2Department of Pharmacology, Science, Mahidol Univ., Bangkok, Thailand, 3Biocatalyst andEnvironmental Biotechnology Research Unit, Biochemistry, Science, Chulalongkorn Univ., Bangkok,
Thailand, 4Department of Biochemistry, Science, Burapha Univ., Chonburi, Thailand, 5National Center
for Genetic Engineering and Biotechnology, Thailand Science Park, Bangkok, Thailand)– S104 –1Pos039

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SARS-CoV-2 スパイク蛋白質と NTD 結合抗体との糖鎖を介した相互作用の解析
Investigation of interactions between SARS-CoV-2 spike and NTD-binding antibody throughglycans
Mao Oide1, Yuji Sugita1,2,3 (1RIKEN CPR, 2RIKEN BDR, 3RIKEN R-CCS)
Recombinant production, functional and structural analysis of antimicrobial peptides in mouse
cryptdin family
Shaonan Yan, Yuchi Song, Yi Wang, Weiming Geng, Shinya Yoshino, Tomoyasu Aizawa (Graduate
School of Life Science, Hokkaido University)
Dictyostelium discoideum の filopodia の cryo-EM 観察
Observation of filopodia in Dictyostelium discoideum by cryo-EM
Yuki Gomibuchi, Yukihisa Hayashida, Yusuke V. Morimoto, Takuo Yasunaga (Grad. Sch Comp. Sci andSys. Eng., KIT)
Unraveling the coupling between conformational changes and ligand binding in ribose binding
protein using MD simulations
Weitong Ren1, Hisham Dokainish1, Ai Shinobu2, Hiraku Oshima2, Yuji Sugita1,2,3 (1RIKEN Cluster for
Pioneering Research, 2RIKEN Center for Biosystems Dynamics Research, 3RIKEN Center for
Computational Science)
コーヒーポリフェノールと乳タンパク質の相互作用に関する分光学的研究
Spectroscopic study of the interaction between coffee polyphenols and milk proteins
Kazuki Horita1,2, Hiroshi Suga1, Atsushi Hirano1,2 (1Grad. Sch. Eng., Chiba Tec., 2NMRI, AIST)
CD28 ペプチドとの相互作用に伴う PI3K nSH2 ドメインの構造動態変化
Changes in structural dynamics of PI3K nSH2 upon interaction with CD28 peptide
Yohei Miyanoiri2, Suyong Re3, Yuhi Hosoe1, Yuya Asahina2, Toru Kawakami2, Masataka Kuroda3,4,
Kenji Mizuguchi2,3, Masayuki Oda1 (1Grad. Sch. Life Environ. Sci., Kyoto Pref. Univ., 2Inst. Prot. Res.,
Osaka Univ., 3ArCHER, Natl. Inst. Biomed. Innov. Health Nutrition, 4Discov. Tech. Lab., Mitsubishi
Tanabe Pharma Corp.)
Acceleration of residue-level coarse-grained molecular dynamics by new development ofparallelization
Jaewoon Jung1,2, Cheng Tan1, Chigusa Kobayashi1, Diego Ugarte1, Yuji Sugita1,2,3 (1RIKEN R-CCS,
2RIKEN CPR, 3RIKEN BDR)
新型コロナウイルスのスパイクタンパク質の動的残基相互作用ネットワーク分析
Dynamic Residue Interaction Network Analysis of the Spike Protein of SARS-CoV-2
Hirokazu Murata, Norifumi Yamamoto (Chiba Tech)
詳細反応モデリングとベイズパラメタ推定による KaiC の多量体構造の機能的役割の解明
Functional roles of the multimeric structure of KaiC revealed by detailed kinetic modeling andBayesian parameter inference
Shin-ichi Koda1,2, Shinji Saito1,2 (1Institute for Molecular Science, 2SOKENDAI)

蛋白質：物性（安定性 折れたたみなど）／Protein: Property
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抗体の親和性成熟と安定性の変化；成熟した C6 とそのジャームライン型抗体
Antibody evolution for antigen binding and stability; maturated C6 and its germline-type
antibodies
Saaya Yabuno1, Takahiro Hayashi2, Masayuki Oda1,2 (1Faculty Life. Environ. Sci., Kyoto Pref. Univ.,
2Grad. Sch. Life. Environ. Sci., Kyoto Pref. Univ.)
抗体の親和性成熟と安定性の変化；抗ニトロフェニル抗体の重鎖 58 番と 102 番残基の役割
Antibody evolution for antigen binding and stability; Role of residues at 58 and 102 of heavy
chain of anti-nitrophenyl antibody
Mutsumi Yoshida1, Yumi Kitagawa2, Masayuki Oda1,2 (1Faculty Life. Environ. Sci., Kyoto Pref. Univ.,
2Grad. Sch. Life. Environ. Sci., Kyoto Pref. Univ.)– S105 –1Pos050
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Amyloid β aggregation and accumulation process under physiological conditions
Masahiro Kuragano, Shinya Yamanaka, Kiyotaka Tokuraku (Grad. Sch. Eng., Muroran Inst. of Tech.)
PSD95-PDZ3 の高温での可逆的なオリゴマー形成における速度論的効果の定量的な評価
The quantitative evaluation of kinetic effect on PSD95-PDZ3’s reversible oligomerization at hightemperature
Tomonori Saotome1, Sawaros Onchaiya2, Jose C Martinez3, Yutaka Kuroda2, Shun-ichi Kidokoro1(1Dept. of Mate. Sci. and Bio., Nagaoka Univ. of Tech., Japan, 2Dept. of Biotech. and Life Sci., Tokyo
Univ. of Agric. and Tech., Japan, 3Dept. of Phys. Chem., Univ. of Granada, Spain)
変性して小さくなる蛋白質
Antibody proteins can be smaller by denaturation
Hiroshi Imamura1,2,3, Ayako Ooishi3, Shinya Honda3 (1Dept. Bio-sci., Nagahama Inst. Bio-Sci. Tech.,
2Coll. Life Sci., Ritsumeikan Univ., 3Biomed. Res. Inst., AIST)タンパク質表面電荷が溶解性に及ぼす影響の格子モデル解析
Lattice-model analysis of protein surface charge distribution on amorphous aggregation andcondensation
Yutaka Kuroda, Yuki Matsuzawa, Shin Kohara (Tokyo University of Agriculture and Technology(TUAT))(1SAA-8) GGGGCC-RNA は、TDP43 およびそのカルボキシ断片の凝集を抑制する(1SAA-8) GGGGCC-RNA prevents aggregation of TDP43 and its carboxy terminal fragments
Ai Fujimoto1, Masataka Kinjo2, Akira Kitamura2 (1Grad. Sch. of Life Sci., Hokkaido. Univ, 2Fac. Adv.
Life Sci., Hokkaido. Univ)
Difference between the Aβ40 and Aβ42 aggregation processes at the atomic level
Satoru G. Itoh1,2,3, Maho Yagi-Utsumi1,2,3,4, Koichi Kato1,2,3,4, Hisashi Okumura1,2,3 (1IMS, 2ExCELLS,
3SOKENDAI, 4Nagoya City Univ.)
翻訳アレスト時のポリペプチド鎖を可視化する試み
Attempt to visualize the synthetic polypeptide during translational arrest
Takehito Tanzawa, Takayuki Kato (IPR., Osaka Univ.)
Kinetic mechanisms of amyloid-β-(16–22) fibrillation
Keisuke Ikeda1, Moe Yamazaki1, Tomoshi Kameda2, Hiroyuki Nakao1, Minoru Nakano1 (1Fac. Pharm.
Sci., Univ. Toyama, 2AIST)
アミロイド β ペプチドの凝集に対する NaCl 結晶の過渡的形成の影響
Effect of temporary NaCl crystal on the aggregation of amyloid β peptides
Masafumi Gushiken, Ikuo Kurisaki, Shigenori Tanaka (Grad. Sch. system infomatics., Univ. Kobe)
リン酸基で修飾したジルコニア粒子を用いた His タグタンパク質の精製
Purification of histidine-tagged proteins using phosphate-modified zirconia particles
Shogo Kanoh1,2, Kentaro Shiraki3, Momoyo Wada2, Takeshi Tanaka2, Msahiro Kitamura4,
Katsuya Kato5, Atsushi Hirano2 (1Pure & Appl. Sci., Univ. Tsukuba, 2NMRI, AIST, 3Pure & Appl. Sci.,
Univ. Tsukuba, 4NGK SPARK PLUG CO., LTD, 5MMRI, AIST)
ヘモグロビンの S 字型酸素結合曲線によるカメレオンモデルの協同性の研究
Testing cooperativity of chameleon model by sigmoidal oxygen binding curve of hemoglobin
Itsuki Yoshida, Tomoki P. Terada (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)
SARS-CoV-2 3CL プロテアーゼと基質ペプチドの結合解離過程の解析
Binding and unbinding kinetics of peptide substrate on SARS-CoV-2 3CL protease
Kei Moritsugu1,2, Akinori Kidera1 (1Grad. Sch. Med. Life Sci., Yokohama City Univ., 2Grad. Sch. Sci.,
OMU)
クモ糸タンパク質フィブロインのナノファイバーの単位構造の解明
A Unit Structure of Nanofiber composed of Spider Silk Protein Fibroin
Rakuri Aiba1, Kento Yonezawa2, Yusuke Okamoto1, Haruya Kajimoto1, Takehiro Sato3,
Yoichi Yamazaki1, Sachiko Toma-Fukai1, Hironari Kamikubo1,2 (1MS.,NAIST, 2CDG., NAIST, 3Spiber
Inc.)– S106 –1Pos063

フィブロインナノファイバーの違いによる延伸乾燥ハイドロゲルの特性の比較
Comparison of Properties of Stretch-Dried Hydrogels with Different Fibroin Nanofibers
Kenta Kimura1, Kento Yonezawa1,2, Yuki Nakatani1, Satoru Onishi1, Haruya Kajimoto1, Takehiro Sato3,
Yoichi Yamazaki1, Sachiko Toma-Fukai1, Hironari Kamikubo1,2 (1NAIST ,MS, 2NAIST, CDG, 3Supiberinc)

蛋白質：機能（反応機構 生物活性など）／Protein: Function
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Role of the si-face Tyr of Bacillus subtilis ferredoxin-NADPH oxidoreductase in the enzymesubstrate interactions
Daisuke Seo (Grad. Sch. Nat. Sci. Tec., Kanazawa Univ.)
SOD1 への基質接近に対する静電ループと Arg143 の役割
Role of electrostatic loop and Arg143 on substrate approach to SOD1
Miu Nakamura1, Yoshifumi Fukunishi2, Juha Lintuluoto3, Masami Lintuluoto1 (1Grad. Sch. Life andEnviron. Sci., Kyoto Pref. Univ., 2AIST, CMB, 3Grad. Sch. Eng., Kyoto univ.)
Truncated mutant of the hemolytic lectin CEL-III revealed the interaction between protomer inhemolytic oligomer
Shuichiro Goda1,2, Keisuke Fukumoto1, Yuta Yamawaki1, Hideaki Unno1, Tomomitsu Hatakeyama1(1Grad. Sch. Of Eng., Nagasaki Univ., 2GaLSIC, Soka Univ.)
Effect of microtubule-binding proteins on microtubule flexural rigidity
Takuto Nakamichi, Kosuke Matsumura, Keiya Shimamori, Kohei Nishida, Kiyotaka Tokuraku,
Masahiro Kuragano (Grad. Sch. Eng., Muroran Inst. of Tech)Characterization of fibrous condensations of CAHS proteins from an anhydrobiotic tardigrade
Seiji Nishimura1, Maho Yagi-Utumi1,2,3, Kazuhiro Aoki2,4, Kazuharu Arakawa2,5, Koichi Kato1,2,3(1Graduate School of Pharmaceutical Sciences, Nagoya City University, 2Exploratory Research Center
on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 3Institute for Molecular
Science (IMS), National Institutes of Natural Sciences, 4National Institute for Basic Biology (NIBB),
National Institutes of Natural Sciences, 5Institute for Advanced Biosciences, Keio University)
微小管切断酵素カタニンの活性評価と高速 AFM による可視化
Biochemical characterization and high-speed AFM visualization of AAA ATPase Katanin
Hayato Shibuya1, Noriyuki Kodera2, Ikuko Hayashi1 (1Grad. Sch. of Med. Lif. Sci., Yokohama City
Univ., 2NanoLS., Kanazawa Univ.)
Target DNA binding dynamics of Staphylococcus aureus Cas9 as revealed by high-speed
atomic force microscopy
Leonardo Puppulin1,2, Junichiro Ishikawa3, Hiroshi Nishimasu3, Mikihiro Shibata1,4 (1Nano Life
Science Institute (WPI-NanoLSI), Kanazawa University, 2Kyoto Prefectural University of Medicine,
Department of Pathology and Cell Regulation, 3Structural Biology Division, Research Center for
Advanced Science and Technology, The University of Tokyo, 4Infinity for Frontier Science Initiative,
Kanazawa University)
Analysis of amyloid β aggregation inhibitory activities and cytotoxicity suppressing activities ofmushroom extracts from Hokkaido
Tuya Gegen1, Rina Sasaki1, Enkhmaa Enkhbat2, Masahiro Kuragano1, Keiya Shimamori1,
Yoshiko Suga2, Yuta Murai2, Masaki Anetai2, Kenji Monde2, Kiyokata Tokuraku1 (1Division of
Sustainable and Environmental Engineering, Muroran Institute of Technology, 2Frontier Research Center
for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University)
Escherichia coli inhibited amyloid β aggregation in a concentration-dependent manner
Sohta Katagiri, Na Zhu, Masahiro Kuragano, Kiyotaka Tokuraku (Grad. Sch. Eng., Muroran Inst. of
Tech.)– S107 –1Pos073

機械学習を用いたペプチドの血圧降下活性の予測
Prediction of antihypertensive activity of peptides using machine learning
Kazushi Tamura, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu (Grad. Sch. Agri. & Life Sci.,
Univ. Tokyo)

蛋白質：計測・解析の方法論／Protein: Measurement & Analysis
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回転拡散と並進拡散の解析による凝集性タンパク質の検出
Detection of protein aggregates using rotational and translational diffusion analysis
Riku Ando1, Johtaro Yamamoto2,3, Akira Kitamura3, Nori Nakai4, Sumio Terada4, Masataka Kinjo3(1Grad. Sch. Life Sci., Hokkaido Univ., 2Nat. Inst. Adv. Ind. Sci. & Tech., 3Fac. Adv. Life Sci., Hokkaido
Univ., 4Grad. Sch. Med. & Dent. Sci., Tokyo Med. & Dent. Univ.)
非発光タンパク質の発光酵素反応
Enzymatic luminous reaction of non-bioluminescent proteins
Ryo Nishihara1,2, Kazuki Niwa1, Tatsunosuke Tomita1, Ryoji Kurita1 (1National Institute of Advanced
Industrial Science and Technology (AIST), 2Japan Science and Technology Agency (JST), PRESTO)(1SBA-4) 3D structural determination of proteins from fluctuation X-ray scattering data
Wenyang Zhao1, Osamu Miyashita1, Florence Tama1,2 (1Center for Computational Science, RIKEN,
2Grad. Sch. Sci., Univ. Nagoya)
残基特異的な熱力学・速度論解析が明らかにするスペクトリン SH3 ドメインの共同性の低い
フォールディング
Reduced cooperativity of spectrin SH3 domain folding revealed by combined per-residue
thermodynamic and kinetic analysis
Seiichiro Hayashi1, Daisuke Fujinami2, Daisuke Kohda1 (1Med. Inst. Bioreg., Kyushu Univ, 2Grad. Sch.
Integr. Pharm. Nutr. Sci., Univ. Shizuoka)
残基特異的 QFER（自由エネルギー 2 次関係）はスムーズな蛋白質折れ畳みを実現するコンシ
ステンシー原理の数学的表現である
Residue-based Quadratic Free Energy Relationship is a Mathematical Formulation of theConsistency Principle of Protein Folding
Daisuke Kohda1, Seiichiro Hayashi1, Daisuke Fujinami2 (1Med. Inst. Bioreg., Kyushu Univ., 2Grad. Sch.
Integr. Pharm. Nutr. Sci., Univ. Shizuoka)
自由エネルギー摂動法を用いた VHH フレームワーク部位のアミノ酸配列最適化
In silico optimization of VHH framework sequence using free energy perturbation method
Kazuma Okada, Yasuhiro Matsunaga (Grad. Sch. Sci. Eng., Saitama Univ.)
新型コロナウイルス並びにインフルエンザウイルス A 型を検出するチオ NAD サイクリング
ELISA 法の開発
Development of Thio-NAD Cycling ELISA for Detection of SARS-CoV-2 and Influenza Virus
Type A
Yuta Kyosei1, Sou Yamura1, Mayuri Namba1, Etsuro Ito1,2 (1Department of Biology, Waseda University,
2Waseda Research Institute for Science and Engineering, Waseda University)
gr Predictor：深層学習を活用したタンパク質水和分布の高速計算法
gr Predictor : An Efficient Method for Computing the Hydration Structure around Proteins using
Deep Learning
Kosuke Kawama1, Yusaku Fukushima1, Mitsunori Ikeguchi2,3, Masateru Ohta3, Takashi Yoshidome1(1Dep. of Appl. Phys., Tohoku Univ., 2Grad. Sch. of Med. Life Sci., Yokohama City Univ., 3RIKEN)
タンパク質の局所構造の形状操作性に関するロボット工学的解析手法
Robotics-Based Method for Analyzing Shape Manipulability of Localized Protein Structures
Keisuke Arikawa (Fcl. Eng., Kanagawa Inst. of Tech.)– S108 –1Pos083

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マルチチェイン/マルチドメインタンパク質の構造変化の解析法について
A method for analyzing structural changes of protein with multi-chains/multi-domains
Chigusa Kobayashi1, Hisham Dokainish2, Suyong Re3, Takaharu Mori2, Jaewoon Jung1,2,Yuji Sugita1,2,4 (1RIKEN R-CCS, 2RIKEN CPR, 3NIBIOHN, 4RIKEN BDR)
Cryo-CLEM 法および Cryo-ET 法による糸状仮足先端の三次元構造観察
Observation of three dimensional structure of filopodial tips by Cryo-CLEM and Cryo-ET
methods
Miho Nakafukasako1, Tomoya Higo1, Yuki Gomibuchi2, Hiroko Takazaki3, Yusuke V. Morimoto2,
Takayuki Kato3, Takuo Yasunaga2 (1Grad. Sch. Comp. Sci. Syst. Eng., Kyushu Inst. Tech., 2Dept. of Phys.
Info. Tech., Kyushu Inst. Tech., 3IPR, Univ. Osaka)
タイムタグ光子測定方式によるナノ秒蛍光相関分光測定システムの開発
Development of the time-tag photon detection method of nanosecond fluorescence correlation
spectroscopy
Yutaka Sano1,2, Hiroyuki Oikawa1,2, Satoshi Takahashi1,2 (1Institute of Multidisciplinary Research for
Advanced Materials, Tohoku University, 2Department of Chemistry, Graduate School of Science, Tohoku
University)
生細胞中の細胞質タンパク質 CRAF の二量体化状態および構造状態遷移に関する詳細解析
Detailed analyses of dimerization state and conformational state transitions of cytoplasmic
protein CRAF in live cells
Kenji Okamoto, Yasushi Sako (RIKEN CPR)
ラマン分光法を用いたタンパク質相分離液滴の濃度と熱力学的性質の検討
Investigation of concentration changes and thermodynamic properties of a single phaseseparated protein droplet using Raman microscopy
Kohei Yokosawa1, Shinji Kajimoto1,2, Takakazu Nakabayashi1 (1Grad. Sch. Pharm. Sci., Tohoku Univ.,
2JST PRESTO)

蛋白質：蛋白質工学／進化工学／Protein: Engineering
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Algorithm and Neural Network-Based Design, and Experimental Evaluations of Antimicrobial
PeptidesJe-Wen Liou1,2,3, Te-Man Liu2, Yu-Ren Chen2, Chin-Hao Yang1, Hemalatha Mani3 (1Department ofBiochemistry, School of Medicine, Tzu Chi University, Hualien, Taiwan, 2Department of Laboratory
Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan, 3Institute of Medical Sciences, Tzu
Chi University, Hualien, Taiwan)
Generation of microtubule superstructures by mimicking ciliary microtubule structures
Muneyoshi Ichikawa1, Hiroshi Inaba2, Yurina Sueki2, Arif Md. Rashedul Kabir3, Takashi Iwasaki4,
Hideki Shigematsu5, Akira Kakugo3, Kazuki Sada3, Tomoya Tsukazaki1, Kazunori Matsuura2 (1Div. ofBiol. Sci., NAIST, 2Grad. Sch. of Eng., Tottori Univ., 3Grad. Sch. of Chem. Sci. and Eng., Hokkaido Univ.,
4Grad. Sch. of Agric. Sci., Tottori Univ., 5Struct. Biol. Div., Jap. Synchrot. Radiat. Res. Instit.)
ウシ由来抗菌ペプチド BMAPs の大量発現系構築および機能・構造解析
Construction of an overexpression system and functional and structural analysis of bovine
antimicrobial peptides BMAPs
Fumi Hirai1, Mitsuki Shibagaki2, Kotaro Tsukioka1, Hao Gu2, Tomoyasu Aizawa1,2 (1Sch. Sci.,
Hokkaido Univ., 2Grad. Sch. Life Sci., Hokkaido Univ.)
ヘリックス–ループ–ヘリックスモチーフのヘリックス–ヘリックス角に着目したタンパク質複合体構造の計算機デザイン
Computational design of protein complexes focusing on the helix–helix angle of the helix-loophelix motif
Marino Yamamoto, Naoya Kobayashi, Shun Hirota (NAIST, Mat. Sci.)– S109 –1Pos092

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機械学習を組み合わせたファージ提示法による抗体断片の指向性進化
Machine-learning application for in vitro selection of antibody fragments from a phage display
library
Sakiya Kawada1, Yoichi Kurumida2, Tomoyuki Ito1, Thuy Duong Nguyen2, Hikaru Nakazawa1,
Hafumi Nishi3,4,5, Yutaka Saito2,6,7,8, Tomoshi Kameda2,8, Koji Tsuda7,8,9, Mitsuo Umetsu1,8 (1Grad. Sch.
Eng., Tohoku Univ., 2AIRC, AIST, 3Grad. Sch. Information Sci., Tohoku Univ., 4ToMMo, Tohoku Univ.,
5Fac. Core Res., Ochanomizu Univ., 6CBBD-OIL, AIST-Waseda Univ., 7Grad. Sch. Frontier Sci., The
Univ. of Tokyo, 8Adv. Intell. Pro., RIKEN, 9MaDIS, NIMS)
ファージ提示ライブラリーを用いた進化分子工学操作への機械学習利用による抗体様分子開発
Machine-learning-assisted molecular evolution with a phage display library of antibody mimetics
Tomoyuki Ito1, Thuy Duong Nguyen2, Yutaka Saito2,3,4,5, Yoichi Kurumida2, Hikaru Nakazawa1,
Sakiya Kawada1, Hafumi Nishi6,7,8, Koji Tsuda4,5,9, Tomoshi Kameda2,5, Mitsuo Umetsu1,5 (1Grad. Sch.
Eng., Tohoku Univ., 2AIRC, AIST, 3CBBD-OIL, AIST-Waseda Univ., 4Grad. Sch. Frontier Sci., The Univ.
of Tokyo, 5Adv. Intell. Pro., RIKEN, 6Grad. Sch. Information Sci., Tohoku Univ., 7ToMMo, Tohoku Univ.,
8Fac. Core Res., Ochanomizu Univ., 9MaDIS, NIMS)
抗菌ペプチド α ディフェンシンの高濃度変性剤存在下における野生型ジスルフィド結合形成機
構の解析
Mechanism of correct disulfide bonds formation of α-defensins in the presence of highconcentrations of denaturing agents
Shinya Yoshino, Hiromichi Taguchi, Yi Wang, Yuchi Song, Weiming Geng, Shaonan Yan,
Tomoyasu Aizawa (Grad. Sch. Life Sci., Hokkaido Univ.)
PD-1 アゴニスト開発に向けた PD-1 結合タンパク質の合理的設計
Rational design of PD-1 binding proteins to develop PD-1 agonists
Hirotaro Shimamura1, Shunji Suetaka2, Nao Sato2, Yuuki Hayashi2,3, Munehito Arai1,2 (1Dept. Phys.,Univ. Tokyo, 2Dept. Life Sci., Univ Tokyo, 3Environmental Science Center, Univ. Tokyo)
Analysis of receptor signaling using growth factor mutants designed by an in silico approach
Yuga Okada1, Akihiro Eguchi2, Daisuke Kuroda3, Kohei Tsumoto1, Ryosuke Ueki1, Shinsuke Sando1(1Grad. Sch. Eng., Univ. Tokyo, 2Faculty of Health and Medical Sciences, University of Copenhagen.,
3National Institute of Infectious Diseases, Ministry of Health, Labour, and Welfare.)
NMR 解析に向けたマウス由来抗菌ペプチド cathelicidin, CRAMP(cathelicidin related antimicrobial peptide)の大腸菌を用いた大量発現系構築
Construction of an overexpression system of mouse-derived antimicrobial peptide cathelicidin,
CRAMP in E. coli for NMR analysis
Kotaro Tsukioka1, Waka Ueda1, Humi Hirai1, Mitsuki Shibagaki2, Hao Gu2, Tomoyasu Aizawa3(1Sch.Sci.,Hokkaido Univ., 2Grad. Sch. Life Sci., Hokkaido Univ., 3Fac. Adv. Life Sci., Hokkaido Univ.)

ヘム蛋白質／Heme proteins
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ナノディスクに再構成した鉄還元膜タンパク質 CYB561D2 によって誘起される脂質過酸化の解析
Analysis of lipid peroxidation induced by iron-reducing membrane heme protein; CYB561D2 in
nanodiscs
Aoi Yamaguchi, Motonari Tsubaki, Tetsunari Kimura (Dept. of Chem., Grad Sch. of Sci., Kobe Univ.)
プロテオリポソーム中における Higd1A によるシトクロム c 酸化酵素の活性増強機構
The positive regulation mechanism of cytochrome c oxidase by Higd1A in proteoliposome
Wataru Sato1, Sachiko Yanagisawa1, Kyoko Shinzawa-Itoh1, Yuya Nishida2, Takemasa Nagao2,
Yasunori Shintani2, Minoru Kubo1 (1Grad. Sch. Sci., Univ. Hyogo, 2Mol. Pharmacol., NCVC)– S110 –1Pos100

酸素バリア性フィルムを利用した嫌気下での構造解析の試み
Attempt to structural analysis under anaerobic condition using oxygen barrier film
Takehiko Tosha1, Kanji Shimba2, Hiroaki Matsuura1, Kunio Hirata1, Masaki Yamamoto1,
Yoshitsugu Shiro2 (1RIKEN SPring-8, 2University of Hyogo)

膜蛋白質／Membrane proteins
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LoCoMock: LogP によって補正されたスコアによるタンパク質-リガンド-膜複合体のドッキング
シミュレーション
LoCoMock: LogP-corrected Membrane Docking Score Screens Protein-Ligand-Membrane
Complexes
Rikuri Morita, Yasuteru Shigeta, Ryuhei Harada (CCS, Univ. Tsukuba)
γ 切断酵素と APP/Notch のドッキング過程の粗視可モデルシミュレーション研究
Coarse-grained model Simulation study of the docking process of γ-secretase and APP/Notch
Chika Minami, Lisa Matsukura, Naoyuki Miyashita (Grad. Sch. BOST, KINDAI Univ.)
遺伝子変異が引き起こす EGFR 動態変化の 1 分子解析
Single-molecule analysis of mutation induced changes in EGF receptor behavior
Michio Hiroshima1,2, Masahiro Ueda1,3 (1RIKEN BDR, 2RIKEN CPR, 3FBS, Osaka Univ.)
1 分子イメージングを用いた薬剤スクリーニング
Drug screening platform using single molecule imaging
Daisuke Watanabe1,2, Michio Hiroshima2, Masahiro Ueda1,2 (1FBS Osaka Univ, 2RIKEN BDR)

核酸結合蛋白質／Nucleic acid binding proteins
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計算科学的に明らかにするホモ二量体チロシル tRNA 合成酵素（TyrRS）のハーフサイト活性
A Computational Study on the Half-Site Activity Mechanism of Homodimeric Tyrosyl tRNA
Synthetase（TyrRS）
Yoshino Okamoto1, Takunori Yasuda2, Rikuri Morita3, Yasuteru Shigeta3, Ryuhei Harada3 (1College of
biological sciences, University of Tsukuba, 2Doctoral program in biology, University of Tsukuba, 3Centerfor computational Sciences)
Elucidation of nucleosome sliding mechanism in all-atom detail via MD simulations
Syed Hashim Shah, Giovanni Bruno Brandani, Shoji Takada (Department of Biophysics, Graduate
school of science, Kyoto University, Kyoto)
PPRP の RNA からの解離機構のシミュレーション研究
Simulation study of the dissociation mechanism of the PPRP with RNA
Sumile Tanaka1, Lisa Matsukura1, Masaki Ottawa2, Naoyuki Miyashita1 (1Grad. Sch. BOST., KINDAI
Univ., 2Sch. Phys. Sci., GUAS)
部分的にアンラップされたヌクレオソームからの、Nap1 による H2A/H2B 解離メカニズム
Nap1 dismantles a H2A/H2B dimer from a partially unwrapped nucleosome
Fritz Nagae, Shoji Takada, Tsuyoshi Terakawa (Grad. Sch. Sci., Kyoto Univ.)– S111 –核酸：構造・物性／Nucleic acid: Structure & Property
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Simulation for the phase separation of DNA droplet with chemical reactions
Ryohei Furuichi1, Tomoya Maruyama2, Akihiro Yamamoto1, Masahiro Takinoue1,2 (1School ofComputing, Tokyo Institute of Technology, 2School of Life Science and Technology, Tokyo Institute ofTechnology)
ヌクレオソーム上を動く酵母 RNApolymeraseⅡの粗子化 MD シミュレーション
Coarse-grained MD simulations of an elongation process of yeast RNA Pol2 moving toward a
nucleosome
Takafumi Yamauchi, Genki Shino, Shoji Takada (Kyoto University)
Mg イオンによるリボザイムのフォールディングとミスフォールディング機構
Mg-induced folding and misfolding of ribozymes
Naoto Hori1, D Thirumalai2 (1School of Pharmacy, University of Nottingham, 2Department of Chemistry,
University of Texas at Austin)
線形および環状 DNA の交流電場応答の直接観測
Dynamics of circular and linear DNA under AC electric fields
Yunosuke Fuji, Shin Takano, Seiwa Yamagishi, Yuuta Moriyama, Toshiyuki Mitsui (Dept. Phys. Sch.
Sci. Aogaku Univ.)
染色体レオロジー特性を介した核内ストレス顆粒のポジショニング機構
Mechanisms of nuclear stress granule positioning in the nucleus via rheological properties ofchromatin
Takuya Nara, Haruko Takahashi, Yutaka Kikuchi (Graduate School of Integrated Sciences for Life,
Hiroshima University)
高分子の表面吸着問題から理解する分裂酵母の構成的ヘテロクロマチン形成
Essence of assembly of constitutive heterochromatin in fission yeast lies in surface adhesionof polymers?
Tetsuya Yamamoto1, Takahiro Asanuma2, Yota Murakami3 (1ICReDD, Hokkaido Univ., 2Grad. Sch.
Chem. Sci. Eng., Hokkaido Univ., 3Dep. Chem, Fac. Sci., Hokkaido Univ.)
クロマチンのもつ液滴の性質
Intrinsic liquid droplet property of chromatin
Kazuhiro Maeshima1, Sachiko Tamura1, Tatsuya Fukuyama2, Yusuke Maeda2 (1National Institute of
Genetics & SOKENDAI, 2Department of Physics, Kyushu University)
修飾核酸特有の低質量プロダクトイオンによる定量を行うソフトウェア
Software for Quantification with Low-mass Product Ions peculiar to Modified Nucleic Acids
Yuki Matsubara1, Masami Koike2, Yuko Nobe3, Hiroko Tsuchida2, Yasuto Yokoi1, Masato Taoka3,
Hiroshi Nakayama2 (1Mitsui Knowledge Industry, 2RIKEN CSRS, 3Tokyo Metropolitan University)
単分散 GUV を用いた濃度制御による DNA 凝集体の生成
GENERATION OF DNA CONDENSATES BY CONCENTRATION CONTROL IN
MONODISPERSE GIANT UNILAMELLAR VESICLES
Ryotaro Yoneyama1, Ryota Ushiyama1, Tomoya Maruyama2, Masahiro Takinoue2,3, Hiroaki Suzuki1(1Graduate School of Science and Engineering, Chuo University, 2Life Science and Technology, Tokyo
Institute of Technology, 3Department of Computer Science, Tokyo Institute of Technology)

核酸：相互作用・複合体／Nucleic acid: Interaction & Complex formation
1Pos118

microRNA の機能発現を 1 細胞 1 分子レベルで可視化する新規技術の開発
In situ single-molecule imaging of microRNA function
Hotaka Kobayashi1,2 (1JST PRESTO, 2IQB, The University of Tokyo)– S112 –1Pos119

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In silico アプローチによるアプタマー-IgG 結合の熱力学的プロファイルの解析
In silico approach for identification of the thermodynamic profiles of aptamer-IgG binding
Ryoji Yamazaki1, Azumi Ito2, Tomoki Sakamoto3,4, Masaki Komine2, Takeshi Ishikawa5,
Masato Katahira3,4, Takashi Nagata3,4, Taiichi Sakamoto2, Kenji Yamagishi1 (1Graduate School ofEngineering Nihon University, 2Faculty of Advanced Engineering Chiba Institute of Technology,
3Graduate School of Energy Science Kyoto University, 4Institute of Advanced Energy, Kyoto University,
5Graduate School of Science and Engineering Kagoshima University)
IgG に結合するアプタマーへの化学修飾の影響
Effect of chemical modification on the aptamer that binds to IgG
Azumi Ito1, Yuuki Yatabe1, Hisae Yoshida2, Masahiro Sekiguchi2, Kazumasa Akita3,
Yoshikazu Nakamura3, Yusuke Nomura4, Takeshi Ishikawa5, Kenji Yamagishi2, Taiichi Sakamoto1(1Chiba Institute of Technology, 2Nihon University, 3Ribomic Inc．, 4National Institute of Health Science,
5Kagoshima University)(2SEP-2) 自由エネルギー地形から探る開始コドン認識機構(2SEP-2) Computational Analysis of the Start Codon Recognition Mechanism Based on Free
Energy LandscapeTakeru Kameda1, Katsura Asano2,3,4, Yuichi Togashi1,5 (1Coll. Life Sci., Ritsumeikan Univ., 2Div. Biol.,Kansas State Univ., 3HiHA, Hiroshima Univ., 4Grad. Sch. Integ. Sci. Life, Hiroshima Univ., 5RIKEN
BDR)
ヌクレオソームから H2A-H2B2 量体が脱離する際の自由エネルギー曲線解析
Analysis of free energy curve of H2A-H2B dimer displacement from the nucleosome
Hisashi Ishida, Hidetoshi Kono (Institute for Quantum Life Science, National Institutes for Quantum
Science and Technology)
細菌の翻訳開始前複合体における tRNA とリボソームタンパク質の相互作用に関する理論的考察
Theoretical investigation of the interactions between a tRNA and ribosomal proteins in bacterialtranslation pre-initiation complex
Yoshiharu Mori, Shigenori Tanaka (Grad. Sch. Sys. Inf., Kobe Univ.)
遠隔操作が可能な DNA 流体のマイクロ流制御
Microflow manipulation of DNA fluid with remote controllability
Hirotake Udono1, Shin-ichiro Nomura M.2, Masahiro Takinoue1 (1Sch. Comp., TiTech, 2Grad. Sch. Eng.,
Tohoku Univ.)
光ピンセットを用いたソレ効果による相分離ドロップレットの生成と DNA 濃縮 II
Generation of Phase Separated Droplet Induced by Soret Effect and DNA Enrichment by
Optical Tweezers II
Mika Kobayashi, Yoshihiro Minagawa, Hiroyuki Noji (Grad. Sch. of Eng., Univ. Tokyo)

電子状態／Electronic state
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一定終状態光電子収量分光法を用いたタンパク質薄膜の電子構造観察
Application of Constant Final State Photoelectron Yield Spectroscopy to Protein Films to
Elucidate Their Occupied Electronic Structure
Masaki Tomita1, Bera Sudipta4, Ryotaro Nakazawa1, Rio Ushiroda1, Ichiro Ide1, Cahen David4,
Hisao Ishii1,2,3 (1GSSE Chiba Univ, 2CFS Chiba Univ, 3MCRC Chiba Univ, 4Weizmann Inst)
電子線回折を利用した構造解析における電子状態を考慮した構造精密化
Structural refinement considering the electron orbitals in structural analysis using electron
diffraction
Yasuhisa Honda, Keigo Takahira, Takuo Yasunaga (Dept of Computer Science and Engineering, Kyushu
Institute of Technology)– S113 –1Pos128

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酸化型[NiFe]ヒドロゲナーゼの生成経路と活性中心の電子・幾何構造についての理論的研究
Theoretical characterization of the active site and its formation pathway in oxidized [NiFe]hydrogenase
Yuta Hori, Yasuteru Shigeta (Center for Computational Sciences, Univ. Tsukuba)
Scala 言語を用いた生体高分子計算科学ツール STCSB への量子化学計算機能の追加
Further development of STCSB, Scala Tool for the Computational Science of Biomolecules, to
add a quantum- chemistry calculation module
Ryoutarou Matsuda, Mika Mitsumatsu, Itaru Onishi, Masayuki Irisa (Kyushu Inst. of tech)

発生・分化／Development & Differentiation
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1Pos133

Continuum model for analyzing mechanical properties of Dictyostelium fruiting-bodydevelopment
Seiya Nishikawa, Satoshi Kuwana, Hidenori Hashimura, Satoshi Sawai, Shuji Ishihara (Grad. Sch. Arts
& Sci., Univ. Tokyo)
ゼブラフィッシュ自己組織化細胞塊における細胞挙動の解析
Characterization of cell dynamics in the process of self-organization in zebrafish explants
Momoka Tochizawa (Dept. Phys. Sch. Sci. Aogaku Univ.)
線虫の初期胚発生における力学モデル
Mechanical Model in Early Embryogenesis of C. elegans
Takehiro Kurihara1, Toshikaze Chiba1, Naohito Urakami2, Kazunori Yamamoto3, Akatsuki Kimura4(1Soft Matter and Biophysics Lab., Department of Physics, Faculty of Science, Tohoku University,
2Graduate School of Sciences and Technology for Innovation, Yamaguchi University, 3Department ofApplied Bioscience, Faculty of Applied Bioscience, Kanagawa Institute of Technology, 4Cell Architecture
Laboratory, Department of Chromosome Science, National Institute of Genetics)
多細胞系の形態形成の近似モデルとしての細胞間相互作用の実効ポテンシャル
Effective mechanical potential of cell-cell interactions: approximated model for multicellularmorphogenesis
Hiroshi Koyama, Toshihiko Fujimori (Div. Embryology., Nat. Inst. Basic Biology)

分子モーター／Molecular motor
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好熱菌 FoF1-ATPase のユニサイト触媒作用の構造的基盤
Structural basis of unisite catalysis of thermophilic FoF1-ATPase
Momoko Aoyama1, Atsuki Nakano1, Jun-ichi Kishikawa2, Ken Yokoyama1 (1Department of Molecular
Biosciences, Kyoto Sangyo Univ., 2IPR, Osaka Univ.)
祖先型 ATPase の作製と機能解析
Resurrection of the Ancestral ATPase
Aya Suzuki1, Ryutaro Furukawa1, Hiroshi Ueno1, Satoshi Akanuma2, Hiroyuki Noji1 (1Grad. Sch. Eng.,
Univ.Tokyo, 2Fac. Human Sci., Waseda Univ)
Rotation dynamics and structure of F1-ATPase with all α-subunit-type P-loops
Hiroshi Ueno1, Meghna Sobti4,5, Rie Koga2, Tomoko Masaike3, Alastair Stewart4,5, Nobuyasu Koga2,
Hiroyuki Noji1 (1Grad. Sch. Eng., Univ. Tokyo, 2ExCELLs, NINS, 3Dept. Appl. Biol. Sci., Tokyo Univ.
Sci., 4Mol. Struct. Comp. Biol. Div., The Victor Chang Cardiac Research Institute, 5Facul. Med., UNSW
Sydney)– S114 –1Pos137

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1Pos147

1Pos148(2SFA-5) Plus and minus ends of microtubules respond asymmetrically to kinesin binding by along-range directionally driven allosteric mechanism
Huong T Vu1, Zhechun Zhang2, Riina Tehver3, Dave Thirumalai4 (1University of Warwick, 2Harvard
University, 3Denison University, 4University of Texas)
Kinesin-1 および Kinesin-14 の In vitro 合成とデザイン
In vitro synthesis and design of kinesin-1 and kinesin-14
Daisuke Inoue1, Ohashi Keisuke2,3, Takasuka Taichi2,3, Kakugo Akira4 (1Fac. Des., Kyushu Univ.,
2Grad. Sch. Glo. Food Res., Hokkaido Univ., 3Res. Fac. Agr. , Hokkaido Univ., 4Fac. Sci., Hokkaido
Univ.)
A novel photochromic regulator inhibits kinesin Eg5 at the ADP sate in the ATPase cycle
Md Alrazi Islam1, Kozue Satoh2, Shinsaku Maruta1,2 (1Grad. Sch. Sci & Eng., Soka Univ., 2Grad. Sch.
Sci & Eng., Soka Univ.)
野生型と疾患関連変異型で構成されるヘテロダイマー KIF1A(キネシン-3)の二足歩行運動モデル
A bipedal walking model for heterodimeric motors composed of wild-type KIF1A and diseaseassociated KIF1A
Tomoki Kita1, Kazuo Sasaki1, Shinsuke Niwa2,3 (1Grad. Eng., Tohoku Univ., 2Grad. Life. Sci., Tohoku
Univ., 3FRIS., Tohoku Univ.)
How does giraffe kinesin cope with the long distance axonal transport?
Taketoshi Kambara1, Daisuke Taniguchi2, Tomoya Mukai3, Yasushi Okada1,2,3,4,5 (1BDR, RIKEN,
2IRCN, Univ. Tokyo, 3Grad. Sch. Sci., Univ. Tokyo, 4Grad. Sch. Med., Univ. Tokyo, 5UBI, Univ. Tokyo)
QCM 測定による周波数変化から測定したアクトミオシン滑り運動の機構
Sliding mechanism of actomyosin motility assay measured from frequency change by QCM
Honoka Kobayashi, Naoki Matsumoto, Taiki Nishimura, Yuki Sakurai, Kaho Yokomuro, Kazuya Soda,
Ikuko Fujiwara, Hajime Honda (Dept. of Matl. Sci. and Bioeng., Nagaoka Univ. of Tech)
QCM 上でのアクトミオシンの滑走速度と周波数変化の関係
The relation between sliding velocities and frequency changes of actomyosin on the QCM
Taiki Nisimura1, Naoki Matumoto1, Honoka Kobayasi2, Yuuki Sakurai1, Kaito Kobayasi1,
Kaho Yokomuro1, Ikuko Hujiwara2, Hajime Honda2 (1Dept. of Bioeng., Nagaoka Univ. of Tech., 2Dept. ofMatl. Sci. and Bioeng., Nagaoka Univ. of Tech.)
鞭毛内輸送を行うダイニンがどのように歩行する微小管を選択するのかに関する粗視化 MD 研究
Coarse-grained MD study on the function of dynein in selecting walking microtubules
Shintaroh Kubo1,2, Huy Bui Khanh2 (1Grad. Sch. Med., The Univ. of Tokyo, 2Dept. Anatomy and Cell
Biol., McGill Univ.)
Discovery of the fastest myosin, its amino acid sequence, and structural features
Takeshi Haraguchi1, Masanori Tamanaha1, Kano Suzuki2, Kohei Yoshimura1, Takuma Imi1,
Motoki Tominaga3,4, Hidetoshi Sakayama5, Tomoaki Nishiyama6, Takeshi Murata2, Kohji Ito1 (1Dept. ofBio. Sci., Grad. Sch. of Sci and Eng., Univ. of Chiba, 2Dept. of Che. Sci., Grad. Sch. of Sci and Eng.,
Univ. of Chiba, 3Grad. Sch. Adv. Sci. and Eng., Univ. Waseda, 4Fac. Educ. Integrated Arts. Sci., Bio.,
Univ. Waseda, 5Dept. of Bio. Sci., Grad. Sch. of Sci., Univ. of Kobe, 6Adv. Sci. Res. Ctr., Univ. ofKanazawa)
バクテリアのべん毛モーターは減速機を持つか？
Does bacterial flagellar motor have a reduction drive?
Ryota Iino1,2 (1IMS, NINS, 2SOKENDAI)
高度好塩菌アーキアの回転モーターのステップ状回転の検出
Detection of stepwise rotation of the archaellar motor in Haloferax volcanii
Yoshiaki Kinosita, Jun Ando, Tastuya Iida, Rikiya Watanabe (Molecular Physiology Lab, RIKEN)
Cryo-EM structure analysis of the PomAB complex, a bacterial flagellar stator of sodium-driven
motor in Vibrio alginolyticus
Tatsuro Nishikino1, Norihiro Takekawa2, Jun-ichi Kishikawa1, Mika Hirose1, Seiji Kojima3,
Michio Homma3, Takayuki Kato1, Katsumi Imada2 (1IPR., Osaka Univ., 2Dept. of Macromol. Sci., Grad.
Sch. of Sci., Osaka Univ., 3Div. Biol. Sci. Grad. Sch. Sci., Nagoya Univ.)– S115 –1Pos149

1Pos150

1Pos151

バクテリアの膜電位揺らぎの解析手法の開発
Development of a method for analyzing membrane potential fluctuations in bacterial cells
Kenta Takemori, Yusuke V. Morimoto (Fac, Comp. Sci. and Sys. Eng., Kyushu Inst. Tech)
分子動力学シミュレーションによる SMC 蛋白質の DNA によって刺激される ATPase 活性の分子機構解明
Molecular Dynamics Simulations to Reveal Molecular Mechanism of DNA-Stimulated ATPase
Activity of SMC Proteins
Masataka Yamauchi, Tsuyoshi Terakawa, Giovanni B. Brandani, Shoji Takada (Dept. of Biophysics,
Grad. of Sci., Kyoto Univ.)
除膜クラミドモナス細胞の巨大リポソームへの封入
Encapsulation of demembranated Chlamydomonas cell into giant liposomes
Koichiro Akiyama, Syunsuke Shiomi, Masahito Hayashi, Tomoyuki Kaneko (Frontier Bioscience,
Hosei Univ.)

細胞生物学的課題（接着，運動，骨格，伝達，膜）／Cell biology
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リゾチームアミロイド線維との接触に対する運動するアクチン線維の応答
Response of a moving actin filament to a contact with a lysozyme amyloid fibril
Kuniyuki Hatori, Ryusei Murata, Kazuto Mima (Dep. Mech. Eng., Yamagata Univ.)
細胞配置換えの分子基盤の解明
Elucidating molecular basis of cell rearrangement
Keisuke Ikawa1, Kaoru Sugimura2 (1Grad. Sch. Sci., Nagoya Univ., 2Grad. Sch. Sci., Univ. Tokyo)
ウニ胚の細胞骨格分布極性に起因する外腸胚形成
Exogastrulation due to cytoskeletal polarity distribution in sea urchin embryo
Kaichi Watanabe1, Yuhei Yasui1, Yuta Kurose2, Naoaki Sakamoto1, Akinori Awazu1 (1Grad. Sch. Int.,
Univ. Hiroshima, 2Grad. Sch. Sci., Univ. Hiroshima)
アクチンとミオシン細胞骨格の組織化によって細胞質のカイラルな回転流が生まれる
Chiral cytoplasmic flow emerging from the spatial organization of actin and myosin cytoskeleton
Takaki Yamamoto, Tomoki Ishibashi, Sylvain Hiver, Mitsusuke Tarama, Yuko Mimori-Kiyosue,
Masatoshi Takeichi, Tatsuo Shibata (RIKEN BDR)
サルモネラ菌の感染時におけるアクチン細胞骨格動態の顕微力学解析
Micromechanical analysis of actin cytoskeleton dynamics during the Salmonella infection
Hiroaki Kubota1, Togo Shimozawa2, Kai Kobayashi1, Morika Mitobe1, Jun Suzuki1, Kenji Sadamasu1(1Dept. Microbiol., Tokyo Metropolitan Institute of Public Health, 2Sch. Sci., Univ. Tokyo)
K+-induced decrease in the matrix pH of mitochondria
Jannatul Naima1,2, Yoshihiro Ohta1 (1Department of Biotechnology and Life Science, Tokyo Universityof Agriculture and Technology, 2Department of Pharmacy, University of Chittagong, Bangladesh)
RacGAP 因子 FilGAP は腎ポドサイトの細胞-基質接着と突起形成を制御する
FilGAP, a GAP for Rac1, controls cell-extracellular matrix adhesion and process formation of
kidney podocytes
Koji Saito1, Seiji Yokawa1, Sari Mizuta1, Kanae Tada1, Moemi Oda1, Hiroyasu Hatakeyama2,
Noriko Takahashi2, Hidetake Kurihara3, Yasutaka Ohta1 (1Division of Cell Biology, Department of
Biosciences, School of Science, Kitasato University, 2Department of Physiology, School of Medicine,
Kitasato University, 3Department of Physical Therapy, Faculty of Health Sciences, Aino University)
パターン化モデル生体膜上でのアクチンのネットワーク形成
Actin network assembly on a patterned model membrane
Yosuke Yamazaki1, Yuri Miyata2, Kenichi Morigaki2,3, Makito Miyazaki1,4,5,6 (1Dept. Phys., Kyoto
Univ., 2Grad. Sch. Agr., Kobe Univ., 3Biosignal, Kobe Univ., 4Hakubi Ctr., Kyoto Univ., 5PRESTO, JST,
6Inst. Curie)– S116 –1Pos160

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細胞中のジュール熱産生
Joule heat production in cells
Tetsuichi Wazawa, Kai Lu, Takeharu Nagai (SANKEN, Osaka Univ)
Highly conserved GYXLI motif of FlhA is directly involved in hierarchical flagellar protein export
in Salmonella
Tohru Minamino1, Miki Kinoshita1, Keiichi Namba1,2 (1Grad. Sch. Frontier Biosci., Osaka Univ.,
2RIKEN SPring-8)
Aberrant shape formation of fission yeast spheroplasts under microfluidic conditions
Hironori Sugiyama1, Yuhei Goto1,2,3, Kazuhiro Aoki1,2,3 (1ExCELLS, NINS, 2NIBB, NINS, 3Sch. Life
Sci., SOKENDAI)
赤外線レーザー照射中の心筋細胞シートの伝導変化
Changes in conduction of cardiomyocyte sheet during infrared laser irradiation
Kentaro Kito, Masahito Hayashi, Tomoyuki Kaneko (Frontier Bioscience, Grad. Sch. Sci. & Eng.,
Hosei Univ.)
好中球様細胞に分化させた HL-60 細胞のケモタキシスにおけるミトコンドリア関連タンパク質の役割
Roles of mitochondria associated protein in chemotaxis of neutrophil-like differentiated HL-60
cells
Yuichi Mazaki1, Tsunehito Higashi1, Yasuhito Onodera2 (1Dept. Cell. Pharm., Grad. Sch. Med.,
Hokkaido Univ, 2Glb. Ctr. Biomed. Sci. Eng., Fac. Med., Hokkaido Univ)
Trans-dimer conformations of full-length ectodomains of Celsr cadherin in solution visualizedusing high-speed atomic force microscopy
Shigetaka Nishiguchi1, Rinshi Kasai2, Takayuki Uchihashi1,3,4 (1ExCELLS, 2iGCORE, Gifu Univ.,
3Nagoya Univ., 4iGCORE, Nagoya Univ.)
アミロイド β 凝集体はヒト脳微小血管内皮細胞の異常なアクチンの組織化と細胞死を誘発する
Amyloid-β aggregates induce abnormal actin organization and death of human brain
microvascular endothelial cell
Keiya Shimamori1, Yushiro Take2, Yusaku Chikai1, Yukina Kuroraki1, Masahiro Kuragano1,
Kiyotaka Tokuraku1 (1Grad. Sch. of Eng., Muroran Inst. of Tech., 2Ohkawara Neurosurgical Hospital)
酸素消費を伴わないミトコンドリア電子伝達機構
Mitochondrial electron transfer mechanism without oxygen consumption
Marino Neda1, Hinako Tanaka1, Emika Shida1, Yoshihiro Ohta2 (1Department of Biotechnology and Life
Sciences, Graduate school of Engineering, Tokyo University of Agriculture and Technology, 2Departmentof Biotechnology and Life Sciences, Associate Professor, Tokyo University of Agriculture andTechnology)
局所加熱法を用いた表皮細胞内変異型ケラチンフィラメント熱ストレス応答の経時変化解析
Time-course analysis of mutant keratin filament dynamics in cultured epidermal cells underthermal stress using a local heating method
Masato Kaya1,2, Hideki Itoh4, Yoshie Harada2,3, E. Birgitte Lane4, Madoka Suzuki2 (1Department of
Biological Sciences, Graduate School of Science, Osaka University, 2Institute for Protein Research,
Osaka University, 3Center for Quantum Information and Quantum Biology, Osaka University, 4Skin
Research Institute of Singapore)
シグナル伝達機構解明のための巨大細胞利用
Use of giant cells to study cell-cell signaling mechanisms
Yukihisa Hayashida, Yusuke Morimoto (Kyushu Institute of Technology (Grad. Sch. Comp. Sci. and Sys.
Eng., Kyushu Inst. Tech ))べん毛のロッド-フック型タンパク質の輸送順序
Transport order of the flagellar rod-hook type proteins
Reika Igarashi, Norihiro Takekawa, Katsumi Imada (Dept. Macromol. Sci., Grad. Sch. Sci., Osaka
Univ.)– S117 –1Pos1711Pos172

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1Pos1811Pos182

無傷のミトコンドリアの単離・保存法の検討
Methods for isolating and preserving intact mitochondria
Asaka Ogihara, Arima Okutani, Wataru Uchiumi, Miki Kanatani, Yoshihiro Ohta (Department of
Biotechnology and Life Sciences, Graduate school of Engineering, Tokyo University of Agriculture andTechnology)
アミロイド β の凝集が細胞の集合に与える影響の解析
Analysis of the effect of amyloid β aggregation on cell assembly
Ayaka Ota, Masahiro Kuragano, Kiyotaka Tokuraku (Grad. Sch. Eng., Muroran Inst. of Tech.)
Theoretical studies on macrophase separation in systems composed of two solutes and one
solvent using a solvent-free coarse-grained model
Yuki Norizoe, Naoki Iso, Takahiro Sakaue (Department of Physical Sciences, Aoyama Gakuin
University)
自発運動する細胞の興奮系 Ras を抑制する GAP の同定
Identification of GAP that suppresses the excitatory Ras in spontaneous cell motility
Guangyu Cheng1, Satomi Matsuoka1,2,3, Masahiro Ueda1,2,3 (1Grad. Sch. Sci., Osaka University, 2Grad.
Sch. of Front. Biosci., Osaka University, 3BDR, RIKEN)
マイコプラズマ・モービレの滑走方向は細胞体の非対称な形状と相関がある
Gliding direction of Mycoplasma mobile correlates with asymmetric configuration of the cell body
Kana Suzuki1, Daisuke Nakane2, Azusa Kage1, Takayuki Nishizaka1 (1Dept. Physics, Gakushuin Univ.,
2Univ. of Electro-Communications)
Direct observation of the functional dynamics by which CAP1 interacts with F-actin and cofilin
by high-speed AFM
Phuong Doan N. Nguyen1, Hiroshi Abe2, Shoichiro Ono3, Noriyuki Kodera4 (1Grad. Sch. NanoLS.,
Kanazawa Univ., 2Dept. Biol., Chiba Univ., 3Dept. Pathol. & Cell Biol., Emory Univ., 4WPI-NanoLSI,
Kanazawa Univ.)細胞の自発運動において Ras 興奮系のノイズ強度の最適化にスフィンゴミエリン代謝系が関与する
Noise generation by sphingomyelin metabolism optimizes Ras excitability for cell migration
Dayoung Shin1,2, Hiroaki Takagi2,3, Michio Hiroshima2, Satomi Matsuoka1,2,4, Masahiro Ueda1,2,4(1Grad. Sch. Sci., Osaka Univ., 2BDR, RIKEN, 3Sch. Med., Nara Med. Univ., 4Grad. Sch. Frontier Biosci.,
Osaka Univ.)
TIRF 観察によるアクチン線維に対するサイトカラシン D の作用理解
Inhibitory mechanism of cytochalasin D on actin by TIRF observations
Takahiro Mitani1, Hikaru Empuku2, Shuichi Takeda3, Ikuko Fujiwara2, Hajime Honda2 (1Dept. of
Bioeng., Nagaoka Univ. of Tech., 2Dept. of Matl. Sci. and Bioeng., Nagaoka Univ. Tech., 3Okayama Univ.,
RIIS)
極性形成に関わる膜タンパク質 Frizzled の細胞間隙での蛍光 1 分子観察
Single molecule observation of polarity-related membrane proteins at the cell-cell interface;immobilization and accumulation of Frizzled
Rinshi Kasai1, Yuri Nemoto2 (1iGCORE, Gifu Univ., 2OIST)Bottom-up strategy による軸糸の屈曲波の再構築
Reconstitution of the axonemal beating by bottom-up strategy
Isabella Guido1, Kenta Ishibashi2, Hitoshi Sakakibara2, Andrej Vilfan3, Eberhard Bodenschatz1,
Ramin Golestanian1, Kazuhiro Oiwa2,4 (1MPI. Dynamics Self-Organization, 2Adv. ICT Res. Inst., NICT,
3Jozef Stefan Inst., 4Grad. Sch. Sci., Univ. Hyogo)
Anomalous dynamics of cardiomyocytes and fibroblasts on PDMS substrate
Arata Nagai, Kaito Kojima, Ryu Kidokoro, Shota Nozaki, Ayu Sasaki, Yuuta Moriyama,
Toshiyuki Mitsui (Dept. Phys. Sch. Sci. Aogaku Univ.)
ミトコンドリア電子伝達系複合体の時間依存的酸化ダメージの検出
Detection of time-dependent oxidative damages of mitochondrial electron transfer complexes
Shizuku Saito, Yoshihiro Ohta (Department of Biotechnology and Life Science, Graduate school ofEngineering, Tokyo University of Agriculture and Technology)– S118 –1Pos183

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回転方向に依存した大腸菌べん毛モーターの回転揺らぎの原因
Investigation for the cause of rotational fluctuations depending on the rotational direction offlagellar motor
Kazumi Akahoshi, Yumiko Uchida, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad. Sch.
Frontier Biosci. Osaka Univ)
酵母ミトコンドリアの膜電位変動観察の試み
Observation of membrane potential fluctuations of yeast mitochondria
Sora Maekawa, Yoshihiro Ohta (Department of Biotechnology and Life Sciences, Graduate school ofEngineering, Tokyo University of Agriculture and Technology)
デスミンフィラメントとアクチンフィラメントとの相互作用の観察
Observation of the interaction between single desmin filaments and single actin filaments in areconstituted motility system
Takumi Ishizaka, Kuniyuki Hatori (Grad. Sch. Sci. Eng., Yamagata Univ.)
1 粒子観察による細胞外小胞の細胞選択的結合の分子機構解明
Molecular mechanisms of selective binding of small extracellular vesicles to recipient cells as
revealed by single-particle imaging
Tatsuki Isogai1, Koichiro M. Hirosawa2, Miki Kanno3, Ayano Syo4, Yasuhiko Kizuka2,5,
Yasunari Yokota6, Kenichi G. N. Suzuki2,5 (1UGSAS, Gifu Univ., 2iGCORE, Gifu Univ., 3Grad. Sch. Nat.
Sci. Tech., Gifu Univ., 4Dept. App. Bio. Sci., Gifu Univ., 5CREST, JST, 6Dept. Eng., Gifu Univ.)

生体膜・人工膜：構造・物性／Biological & Artificial membrane: Structure & Property
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1Pos190

1Pos191Morphology of Adhering Vesicles
Toshikaze Chiba1, Hironori Sugiyama2, Taro Toyota3, Yuka Sakuma1, Masayuki Imai1, Primož Ziherl4,5(1Department of Physics, Tohoku University, 2ExCELLS, National Institutes of Natural Sciences,
3Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, 4Facultyof Mathematics and Physics, University of Ljubljana, 5Jožef Stefan Institute)
基板支持リン脂質積層膜の軟 X 線直線偏光による相状態解析
Soft X-ray polarization analysis of lipid order for phospholipid multilayers supported onhydrophilic surfaces
Shin-ichi Wada1,2, Masataka Tabuse1 (1Grad. Sch. Adv. Sci. Eng., Hiroshima Univ., 2HiSOR, Hiroshima
Univ.)
薬剤代謝におけるコレステロールの役割を探るためのモデル生体膜と薬剤の相互作用研究：リン脂質 POPE/コレステロール/クロルゾキサゾン系
A model biomembrane study on the role of cholesterol in cytochrome P450 drug metabolism:
POPE/cholesterol/ chlorzoxazone systems
Shosei Kano, Hiroshi Takahashi (Grad. Sch. Sci. Tech., Gunma Univ.)
薬物添加による血液脳関門モデル膜の膜厚変化に関する X 線回折研究：スフィンゴミエリンの役割
An X-ray diffraction study of changes in the blood-brain barrier model membrane thickness
induced by adding drugs : role of sphingomyelin
Anna Ajima, Hiroshi Takahashi (Grad. Sch. Sci. Tech., Gunma Univ.)
パターン化人工膜へのエクソソーム導入技術の開発
Reconstitution of exosomes into a patterned model membrane
Yu Yoshimura1, Ayane Sugimachi1, Fumio Hayashi2, Koichiro M. Hirosawa3, Rinshi S. Kasai3,
Kenichi G. N. Suzuki3, Kenichi Morigaki1,4 (1Grad. Sch. Agri., Kobe Univ., 2Grad. Sch. Sci., Kobe Univ.,
3iGCORE, Gifu Univ., 4Biosignal Research Center, Kobe Univ.)– S119 –1Pos192

Laurdan の時間分解蛍光解析法からみる脂質膜水和状態
Lipid-Surrounding Hydration States Probed by Time-Resolved Emission Spectra of Laurdan
Nozomi Watanabe1, Keishi Suga2, J. Peter Slotte3, Thomas K. M. Nyholm3, Hiroshi Umakoshi1(1Graduate School of Engineering Science, Osaka University, 2Graduate School of Engineering, Tohoku
University, 3Faculty of Science and Engineering, Åbo Akademi University)

生体膜・人工膜：ダイナミクス／Biological & Artificial membrane: Dynamics
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エクソソーム評価系としてのブラウン運動解析
Brownian motion analysis as an exosome evaluation system
Kei Takahashi, Yui Miyabayashi, Takuo Yamaki (CellSource Co., Ltd.)
細胞質型ホスホリパーゼ A2 活性化とセラミド 1-リン酸の膜動態の関連性
Relationship between the membrane dynamics of ceramide 1-phosphate domains and theactivation of cytosolic phospholipase A2
Tomokazu Yasuda1,2, Daiki Ueura1, Madoka Nakagomi2, Shinya Hanashima1, J Peter Slotte3,
Michio Murata1 (1Graduate School of Science, Osaka University,, 2Research Foundation Itsuu
Laboratory, 3Åbo Akademi University)
浸透圧下の巨大リポソームでの抗菌ペプチド・マガイニン 2 のポア形成とその進化
Antimicrobial peptide magainin 2 (Mag)-induced pore formation and its evolution in single GUVs
under osmotic pressure (Π)
Md. Masum Billah1, Samiron Kumar Saha1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci. Tech., Shizuoka
Univ., 2Res. Inst. Ele., Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
酸性アミノ酸の側鎖長を調整することによる環状ペプチドの pH 依存性膜透過性の制御
Control of pH-dependent membrane permeation of cyclic peptides by adjusting side chain
length of acidic amino acids
Motomi Matsuda, Keisuke Ikeda, Minoru Nakano, Hiroyuki Nakao (Grad. Sch. Med. Phar. Sci., Univ.
Toyama / Japanese)
粗視化陰溶媒脂質力場、iSoLF、を用いて GENESIS による多成分脂質システムの分子動力学シ
ミュレーション
Extension of the Implicit Solvent Lipid Force Field, iSoLF, for the simulation of large multicomponent lipidic systems using GENESISDiego Ugarte1, Shoji Takada2, Yuji Sugita1,3,4 (1Computational Biophysics Research Team, RIKEN RCCS, 2Dept. Biol., Sch. Sci., Kyoto Univ., 3Laboratory for Biomolecular Function Simulation, RIKEN
BDR, 4Theoretical Molecular Science Laboratory, RIKEN CPR)
一定張力による GUV 中のポア形成に対する脂質成分や分布の効果
Effect of lipid composition and distribution on constant tension-induced pore formation in GUVs
Kanta Tazawa1, Junichi Higuchi1, Masahito Yamazaki1,2,3 (1Grad. Sch. Sci., Shizuoka Univ, 2Res. Inst.
Ele., Shizuoka Univ., 3Grad. Sch. Sci. Tech., Shizuoka Univ.)

生体膜・人工膜：興奮・チャネル／Biological & Artificial membrane: Excitation & Channels
1Pos199

Design and characterization of enzyme-responsive synthetic ion channels
Iiro Kiiski1, Nanami Takeuchi1, Alexandre Legrand2, Reiko Sakaguchi3, Kenji Usui4, Shuhei Furukawa2,
Ryuji Kawano1 (1Tokyo University of Agriculture and Technology, 2Kyoto University, 3University ofOccupational and Environmental Health, 4Konan University)– S120 –1Pos200

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膜水系における環状人工イオンチャネルの QM/MM シミュレーション
QM/MM simulations of cyclic artificial ion channel in membrane-water system
Mayuko Nakagawa1, Toru Ekimoto1, Tsutomu Yamane2, Kohei Sato3, Kazushi Kinbara3,
Mitsunori Ikeguchi1,2 (1Dept. of Med. Life Sci., Yokohama City Univ., 2R-CCS, Riken, 3Sch. of Life Sci.
and Tech., Tokyo Inst. of Tech.)
CBB 法を用いた再構成膜でのアクアポリン 6 のイオン透過特性の解析
Ion conducting properties of Aquaporin 6 reconstituted in the contact bubble bilayer
Takahisa Maki1, Shigetoshi Oiki2, Masayuki Iwamoto1 (1Dept. Mol. Neurosci., Facul. Med. Sci., Univ.
Fukui, 2Biomed. Imaging Res. Center, Univ. Fukui)
アガロースゲルビーズを用いた人工膜チャネル電流測定
An artificial lipid bilayer ion-channel recording method using agarose gel beads
Mami Asakura1, Atsuya Mukuno1, Minako Hirano2, Toru Ide2 (1Fac. Eng., Okayama Univ., 2Grad. Sch.
Health Sys., Okayama Univ.)

生体膜・人工膜：輸送・情報伝達／Biological & Artificial membrane: Transport & Signal transduction
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リポソーム内タンパク質機能発現制御のための膜透過性ペプチドの利用
Use of Cell penetrating peptide for the regulation of protein functional expression in giant
unilamellar vesicles
Akari Miwa, Koki Kamiya (Grad. Sch. Sci. Tech., Gunma Univ.)
Development of DNA nanostructures that function as artificial channel/transducer on a giant
vesicle membrane
Shoji Iwabuchi1, Yusuke Sato2, Ibuki Kawamata1,3, Satoshi Murata1, Shin-ichiro Nomura1 (1Tohoku
University, 2Kyushu Institute of Technology, 3Ochanomizu University)
Membrane Permeability of Mono-Amino Acids Estimated by Planar Lipid Bilayer System
Kaiyi Zheng, Kayano Izumi, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo
University of Agriculture and Technology, Japan)
分子動力学計算による CLCF における F-輸送機構の解析
F- export mechanism in CLCF using molecular dynamics simulations
Akihrio Nakamura1,2, Takashi Tokumasu2, Takuya Mabuchi2,3 (1Graduate School of Engineering,Tohoku University, 2Institute of Fluid Science, Tohoku University, 3Frontier Research Institute forInterdisciplinary Sciences, Tohoku University)
筋小胞体 Ca ポンプのヘリックス M2 と M6 の Ca 輸送における役割
Role of M2 and M6 helices of sarcoplasmic reticulum Ca pump in Ca transport
Takashi Daiho (Asahikawa Med. Univ. Biochemistry)
PI3K シグナル伝達は S-G2 期の ERK の時間的調節において重要な役割を果たす
PI3K signaling plays a critical role in the temporal regulation of ERK in the S-G2 phase
Ryo Yoshizawa, Nobuhisa Umeki, Yasushi Sako (Wako Inst., Riken)
ペプチドナノディスクを用いた光受容体ロドプシンのパターン化モデル生体膜への再構成
Reconstitution of photoreceptor rhodopsin into a patterned model membrane using peptide
nanodisc
Masato Koezuka1, Fuko Kueda2, Fumio Hayashi3, Kenichi Morigaki2,4 (1Fac. Agri., Kobe Univ., 2Grad.
Sch. Agri., Kobe Univ., 3Grad. Sch. Sci., Kobe Univ., 4Biosignal Research Center, Kobe Univ.)– S121 –光生物：視覚・光受容／Photobiology: Vision & Photoreception
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1Pos218

色素再構成系を用いたシアノバクテリオクロム型光受容体の光変換機構の解析
Analysis of the photoconversion mechanism of cyanobacteriochrome-class photosensors using
in vitro reconstitution approach
Takaaki Matsushita, Toshihiko Eki, Yuu Hirose (Toyohashi Univ. of Tech)
Thermodynamic and kinetic factors affecting the redox chemistry of a flavin cofactor inphotolyases
Yuhei Hosokawa, Hiroyoshi Morita, Mai Nakamura, Shigenori Iwai, Junpei Yamamoto (Grad. Sch. Eng.
Sci., Osaka Univ.)
ロドプシンクラスター上における G 蛋白質トランスデューシンの高速 AFM による 1 分子動態観察
Single molecule observation of G protein transducin on rhodopsin cluster by high-speed AFM
Hayato Yamashita1, Akihiro Tsuji1, Fumio Hayashi2, Kenichi Morigaki3,4, Masashi Fujii5,6,
Akinori Awazu5,6, Kazuhiko Hoshikaya1, Masayuki Abe1 (1Grad. Sch. Eng. Sci., Osaka Univ., 2Grad.
Sch. Sci., Kobe Univ., 3Grad. Sch. Agr. Sci., Kobe Univ., 4Biosignal Research Center, Kobe Univ., 5Grad.
Sch. Sci., Hiroshima Univ., 6Grad. Sch. Int., Hiroshima Univ.)
繊毛型光受容細胞で機能するオプシンにおける収斂的な対イオン変位
Convergent evolutionary counterion displacement of ciliary opsins
Kazumi Sakai, Hiroki Ikeuchi, Chihiro Fujiyabu, Yasushi Imamoto, Takahiro Yamashita (Grad. Sch. ofSci., Kyoto Univ.)
光サイクル型視覚ロドプシンを用いた細胞内 cAMP 濃度の一過的変化誘導Transient induction of intracellular cAMP level changes using photocyclic visual rhodopsin
Kazumi Sakai, Shion Aoki, Takahiro Yamashita (Grad. Sch. Sci., Kyoto Univ.)
新奇微生物ロドプシン・ベストロドプシンのユニークな発色団レチナール異性化特性
Unique chromophore isomerization properties of a novel microbial rhodopsin bestrhodopsin
Takashi Nagata1, Yuma Kawasaki1, Masae Konno1,2, Yujiro Nagasaka1, Mako Aoyama3,
Kota Katayama2,3, Andrey Rozenberg4, Igor Kaczmarczyk5, Donna Matzov5, Moran Shalev-Benami5,
Oded Béjà4, Hideki Kandori3, Keiichi Inoue1 (1ISSP, Univ. Tokyo, 2PRESTO, JST, 3Nagoya Inst. Tech.,
4Technion–Israel Inst. Tech., 5Weizmann Inst. Sci.)
新規微生物ロドプシン SmChR のイオン透過性
Ion permeability of the novel microbial rhodopsin SmChR
Yo Yamashita1, Shoko Hososhima1, Suneel Kateriya2, Hideki Kandori1, Satoshi Tsunoda1 (1Nagoya
Institute of Technology, 2Laboratory of Optobiology, Jawaharlal Nehru University, India)(2SCA-2) Conversion of light-driven outward proton pump rhodopsin into inward proton pump
Maria Del Carmen Marin Perez1, Masae Konno1,2, Himoru Yawo1, Keiichi Inoue1 (1ISSP, Univ. Tokyo,
2PRESTO, Japan Science and Technology Agency)
宿主由来のレチナールを利用する共生細菌 Saccharibacteria 由来 Type-1 ロドプシンの分子特性
Molecular properties of Type-1 rhodopsin from Saccharibacteria that may use host-derived alltrans retinal
Masae Konno1,2, Alexander L. Jaffe3, Yuma Kawasaki1, Chihiro Kataoka4, Oded Béjà5,
Hideki Kandori4,6, Jillian F. Banfield7,8,9, Keiichi Inoue1 (1The Institute for Solid State Physics, The
University of Tokyo, 2PRESTO, Japan Science and Technology Agency, 3Department of Plant andMicrobial Biology, University of California, 4Department of Life Science and Applied Chemistry, Nagoya
Institute of Technology, 5Faculty of Biology, Technion-Israel Institute of Technology, 6OptoBioTechnology
Research Center, Nagoya Institute of Technology, 7Innovative Genomics Institute, University ofCalifornia, 8Department of Earth and Planetary Science, University of California, 9Department ofEnvironmental Science, Policy, and Management, University of California)– S122 –1Pos219

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1Pos222高熱安定性光駆動型内向き H+ポンプロドプシンにおける熱安定性要因の研究
Study on the factors contributing to the high thermal stability of thermostable light-driven inward
H+ pump rhodopsins
Yuma Kawasaki1, Masae Konno1,2, Keiichi Inoue1 (1ISSP, Univ. Tokyo, 2JST・さきがけ)
多様な温度環境に分布するプロトンポンプ型ロドプシンの熱力学的性質の網羅的解析
Comprehensive thermodynamic analysis for microbial proton pump rhodopsins identified invarious temperature environments
Ryouhei Ohtake1, Kaori Kondo1, Makoto Demura2, Takashi Kikukawa2, Takashi Tsukamoto2(1Graduate School of Life Science, Hokkaido University, 2Faculty of Advanced Life Science, Hokkaido
University)
光駆動 Na+/H+ハイブリッドポンプ型ロドプシン KR2 における N112 変異体のプロトン選択的ポンプ機構の研究
Study of proton-selective pumping mechanism of N112 mutants in light-driven Na+/H+ hybrid
pump-type rhodopsin KR2
Yuki Ichikawa1, Yuji Furutani1,2 (1Graduate School of Engineering, Nagoya Institute of Technology,
2OptoBio, Nagoya Institute of Technology)
Time-resolved cryo-Raman study of Na+ uptake and release by a sodium pumping
rhodopsin from Indibacter alkaliphilus
Tomotsumi Fujisawa1, Kouta Kinoue1, Ryouhei Seike1, Takashi Kikukawa2, Masashi Unno1 (1Fac. Sci.
Eng., Saga Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)

光生物：光合成／Photobiology: Photosynthesis
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励起子電荷分離混成が酸素発生型光合成を駆動する
Exciton-charge transfer mixing drives oxygenic photosynthesis
Yusuke Yoneda1,2,3, Eric A. Arsenault1,2, Shiun-Jr Yang1,2, Kaydren Orcutt1,2, Masakazu Iwai1,2,
Graham R. Fleming1,2 (1University of California, Berkeley, 2Lawrence Berkeley National Laboratory,
3Institute for Molecular Science)
遠赤色光に適応した光化学系 I の光捕集における Chlorophyll-f と Red-Chlorophyll の役割に関する理論的研究
Theoretical study on the role of Chlorophyll-f and Red-Chlorophyll in light-harvesting mechanism
in far-red light adapted photosystem I
Yuka Nakamura, Mikihito Okochi, Shigeru Itoh, Akihiro Kimura (Grad. Sch. Sci., Nagoya Univ.)
Electrostatic charge controls spectral properties and thermal stabilities of LH1-RCs from triply
extremophilic Halorhodospira halochloris
Yukihiro Kimura1, Kazuna Nakata1, Shingo Nojima1, Shinji Takenaka1, Michael T. Madigan2,
Zheng-Yu Wang-Otomo3 (1Department of Agrobioscience, Graduate School of Agriculture, Kobe
University, 2Department of Microbiology, Southern Illinois University, 3Faculty of Science, Ibaraki
University)
フェムト秒ポンプ・プローブ分光法によるヘリオバクテリア反応中心におけるカロテノイドの励起エネルギー移動解析
Analysis of excitation energy transfer of carotenoids in the reaction center of heliobacteria withfemto-second pump-probe spectroscopy
Risa Kojima1, Masatoshi Kida2, Daisuke Kosumi3, Hirozo Oh-oka1,4 (1CELAS, Osaka Univ., 2Grad. Sch.
Sci. & Tech., Kumamoto Univ., 3IINa, Kumamoto Univ., 4Grad. Sch. Sci., Osaka Univ.)– S123 –1Pos227

1Pos228

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1Pos231FTIR monitoring of photosynthetic quinone transport in the light-harvesting 1 reaction center
complexes from purple bacteria
Yosuke Nakamoto1, Rikako Kishi1, Shinji Takenaka1, Michael T. Madigan2, Kenji V. P. Nagashima3,
Zheng-Yu Wang-Otomo4, Yukihiro Kimura1 (1Department of Agrobioscience, Graduate School of
Agriculture, Kobe University, 2Department of Microbiology, Southern Illinois University, 3ResearchInstitute for Integrated Science, Kanagawa University, 4Faculty of Science, Ibaraki University)
Wavelength-Dependent Optical Response of Single Photosynthetic Antenna Complexes from
Siphonous Macrogreen Alga Codium fragile
Tatas H. P. Brotosudarmo1,2, Bernd Wittmann1, Soichiro Seki3, Ritsuko Fujii3,4, Jürgen Köhler1(1Spectrosc. Soft Matter, Univ. Bayreuth, Germany, 2Dept. Food Tech., Univ. Ciputra, Surabaya,
Indonesia, 3Grad. Sch. Sci., Osaka City Univ., Japan, 4ReCAP., Osaka Metropolitan Univ., Japan)
クロロフィル f を含む光化学系Ⅰの近赤外光による反応メカニズム解明を目指した蛍光バンドの帰属
Assignment of fluorescence bands of chlorophyll-f containing photosystem I to elucidate its
reaction mechanism by near-infrared light
Rin Taniguchi1, Toshiyuki Shinoda2, Tatsuya Tomo2, Shen Ye1, Yutaka Shibata1 (1Department ofChemistry, Graduate School of Science, Tohoku University, 2Department of Biology, Faculty of Science,
Tokyo University of Science)
緑色硫黄細菌の光合成反応中心複合体の表在性タンパク質の結合は PscB が足場となる
PscB is the scaffold for binding of other water-soluble subunits to the photosynthetic reaction
center complex of green sulfur bacteria
Tomomi Inagaki, Kazuki Terauchi, Chihiro Azai (Grad. Sch. Life Sci., Ritsumeikan Univ.)
極性カロテノイドの結合性向上を目指したシフォナス緑藻の光合成アンテナの in-vitro 再構成
Enhancement of polar-carotenoid binding in in-vitro reconstitution of a photosynthetic lightharvesting complex from siphonous green alga
Hikari Takakura1, Naoko Norioka2, Naohiro Oka3, Soichiro Seki1, Hideaki Tanaka2,4, Genji Kurisu2,4,
Ritsuko Fujii1,5 (1Grad. Sch. Sci., Osaka City Univ., 2Inst. Protein Res., Osaka Univ., 3BRIC., Tokushima
Univ., 4Grad. Sch. Sci., Osaka Univ., 5ReCAP., Osaka Metropolitan Univ.)

光生物：光遺伝学・光制御／Photobiology: Optogenetics & Optical Control
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Ras photocontrol by regulatory factor GAP modified with azobenzene derivative.
Rajib Ahmed, Nobuyuki Nishibe, Natsuki Yamamura, Kazunori Kondo, Shinsaku Maruta (Departmentof Biosciences, Graduate School of Science and Engineering Soka University, Hachioji, Tokyo.)
藍色光を吸収するチャネルロドプシン KnChR のイオン選択性と光遺伝学
Ion selectivity and optogenetics application of a deep blue absorbing channelrhodopsin
Satoshi Tsunoda1,2, Rintaro Tashiro1, Shoko Hososhima1,2, Hideki Kandori1,2 (1Nagoya Institute ofTechnology, Department of Life Science and Applied Chemistry, 2Nagoya Institute of Technology,
OptoBioTechnology Research Center)G タンパク質 βγ サブユニット依存的イオンチャネル応答を選択的に駆動する無脊椎動物オプシン
An invertebrate opsin functionally biased for Gβγ-dependent ion channel responses
Hisao Tsukamoto1, Yoshihiro Kubo2 (1Department of Biology, Kobe University, 2Department of
Molecular Physiology, National Institute for Physiological Sciences)
微生物型ロドプシンの吸収波長とプロトン移動の制御機構
Regulation of absorption wavelength and proton transfer in microbial rhodopsins
Masaki Tsujimura1, Hiroshi Ishikita1,2 (1Grad. Sch. Eng., Univ. Tokyo, 2RCAST., Univ. Tokyo)– S124 –1Pos236

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Photocontrol of chromatin remodelers Snf2 and BRG1 as an ATP driven molecular motor byphotoresponsive protein Dronpa
Choi Eunji1, Ziyun Zhang1, Shinya Watanabe2, Kazunori Kondo1, Shinsaku Maruta1 (1Grad. Sch. Sci.,
Univ. Soka, 2Med. Sch., Univ. Massachusetts)
QM/MM 分子シミュレーションによる光活性化酵素 OaPAC の研究
Study on photoactivated enzyme OaPAC by QM/MM molecular simulation
Masahiko Taguchi, Shun Sakuraba, Justin Chan, Hidetoshi Kono (Inst. Quant. Life Sci., QST)

生命の起源・進化／Origin of life & Evolution
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1Pos239

1Pos240

1Pos241

1Pos2421Pos243

Cationic Polyester Microdroplets as RNA-containing Protocells
Tony Z Jia1,2, Niraja V. Bapat1,3, Ajay Verma3, Irena Mamajanov1, H. James Cleaves II1,2,
Kuhan Chandru4 (1Earth-Life Science Institute, Tokyo Institute of Technology, 2Blue Marble Space
Institute of Science, 3Department of Biology, Indian Institute of Science Education and Research, 4Space
Science Centre (ANGKASA), Institute of Climate Change, National University of Malaysia)
DNA 相互作用を用いたコアセルベート間でのタンパク質輸送
DNA-Mediated Protein Shuttling between Coacervate-Based Artificial Cells
Tsuyoshi Mashima1, Jan van Hest2, Luc Brunsveld2 (1NAIST, 2Eindhoven Univ. Tech.)
ベシクルの自己生産: 人工ミニマルセルのボトムアップなデザイン
Reproduction of Vesicles: The Bottom-up Design for Synthetic Minimal Cell
Minoru Kurisu1, Peter Walde2, Yuka Sakuma1, Masayuki Imai1 (1Dept. Physics, Grad. Sch. Sci., Tohoku
Univ., 2ETH Zurich)
配列情報と連携したベシクル膜の成長：進化可能なミニマルセルを目指して
Vesicle membrane growth coupled with sequence information: toward evolvable minimal cell
Ryosuke Katayama, Minoru Kurisu, Yuka Sakuma, Masayuki Imai (Grad. Sch. Sci., Tohoku Univ.)
Formation of self-growing artificial cell droplets in aqueous two-phase separation system byinternal amplification of nucleic acids
Yoshihiro Minagawa, Moe Yabuta, Hiroyuki Noji (Department of Applied Chemistry, Graduate Schoolof Engineering, The University of Tokyo.)細胞モデル進化における表現型拘束に起因した交差耐性
Cross-resistance induced by phenotypic constraint in a cell model evolution
Takuya Sato1, Kunihiko Kaneko2 (1RIKEN, BDR, 2Niels Bohr Institute)

ゲノム生物学：ゲノム機能／Genome biology: Genome function
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Coarse-grained modeling of Nanog gene locus: Towards understanding enhancer-promoter
communication
Soundhara Rajan Gopi1, Giovanni Brandani1, Cheng Tan2, Jaewoon Jung2,3, Chenyang Gu1,
Azuki Mizutani1, Chigusa Kobayashi2, Hiroshi Ochiai4,5, Yuji Sugita2,3,6, Shoji Takada1 (1Department ofBiophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan, 2Computational
Biophysics Research Team, Riken Center for Computational Science, Kobe 650-0047, Japan,
3Theoretical Molecular Science Laboratory, RIKEN cluster for Pioneering Research, Saitama 351-0198,
Japan, 4Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life,
Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8511, Japan, 5Genome Editing Innovation
Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8511, Japan, 6Laboratory for
Biomolecular Function Simulation, RIKEN center for Biosystems Dynamics Research, Kobe 650-0047,
Japan)– S125 –1Pos245

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Biochemical fractionation separating open and compact chromatin based on local assembly ofadjacent nucleosomes
Satoru Ishihara (Fujita Health Univ. Sch. Med.)
1 分子イメージングで迫るヒト染色体の凝縮機構
Single molecule imaging unveils human chromosome condensation
Kayo Hibino1,2,3, Yuji Sakai4, Masato Kanemaki1,2, Kazuhiro Maeshima1,2 (1NIG, 2SOKENDAI, 3JST,
PRESTO, 4Inst. LiMe, Kyoto Univ.)

生命情報科学：分子進化／Bioinformatics: Molecular evolution
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1Pos251

HDV ゲノムの分子進化における二次構造の制約の解析
Constraint of Base Pairing on HDV Genome Evolution
Saki Nagata, Ryoji Kiyohara, Hiroyuki Toh (Grad. Sch. of Sci. Tech., KGU)GPCR 間相互作用ペア予測手法の改善
Improvement of a method to predict interacting GPCR-GPCR pairs
Aoi Fukushima1, Hiroaki Teruse2, Sakie Shimamura1, Hiroyuki Toh2, Wataru Nemoto1 (1Dept. Sch. &Tech., Tokyo Denki Univ., 2Dept. of Sci. & Tech., Kwanseigakuin Univ.)
Chiral selectivity mechanism on aminoacylation of an RNA minihelix studied by quantum
mechanics/molecular mechanics simulations
Tadashi Ando (Dep. of Appl. Elec., Tokyo Univ. of Sci.)
光ピンセットを用いた fL リアクタ回収技術の開発
Development of new DNA recovery technology from fL droplet array using optical tweezers
Tetsuya Ohashi, Hiroshi Ueno, Yoshihiro Minagawa, Hiroyuki Noji (Department of Applied Chemistry,
Univ. Tokyo)
深層生成モデル CM-VAE を用いた RNA ファミリー人工配列生成
CM-VAE: a generative model for designing artificial members of RNA family
Shunsuke Sumi1,2, Michiaki Hamada2, Hirohide Saito2 (1Center for iPS Cell Research and Application,
Kyoto University, 2Graduate School of Advanced Science and Engineering, Waseda University)

生態／環境／Ecology & Environment
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1Pos253

人工的微生物複合系において観察された機能的安定性と不安定性
Functional stability and instability observed in engineered microbial complex systems
Rei Ikeda1, Koki Amano1, Masahiro Honjo2, Nobuhiro Takahashi1, Kenshi Suzuki3, Futoshi Kurisu4,
Motohiko Kimura1, Yosuke Tashiro1, Hiroyuki Futamata5 (1Department of Applied Chemistry andBiochemical Engineering, Graduate School of Engineering, Shizuoka University, 2Graduate School of
Science and Technology, Shizuoka University, 3Microbial Ecotechnology, Department of Biotechnology,
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 4Research Center for Water
Environment Technology, School of Engineering, The University of Tokyo, 5Research Institution of Green
Science and Technology, Shizuoka University)
Diversity of swimming endurance and foraging strategy in marine bacteria
Kyosuke Takabe1, Yiyun Zhang2, Katsuki Hara2, Tomohiro Hirayama2, Yutaka Yawata1,3 (1Faculty ofLife and Environmental Sciences, University of Tsukuba, 2Master’s Program in Agro-Bioresources
Science and Technology, University of Tsukuba, 3Microbiology Research Center for Sustainability,
University of Tsukuba)– S126 –1Pos254

北海道南部産ダルス内の PE 量に光が与える影響
Effect of light on the amount of PE in dulse from southern Hokkaido
Yukiko Sawayama, Yuzuka Takahashi, Rio Fukuda, Hibiki Nakamura (HAKURYO High School
attached to Hakodate University)

数理生物学／Mathematical biology
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3 次元形態形成を表す隣接細胞間ネットワークモデル
Simulating Three-Dimensional Epithelial Morphogenesis: A Network Model Based on theInteractions Between Adjacent Cells
Tomohiro Mimura, Yasuhiro Inoue (Grad. Sch. Eng.,Univ. Kyoto)
空間的局所相互作用を伴う動的可塑的ネットワーク系の自発的構造形成
Spontaneous Network Organizations of Dynamic-Plastic Network System with Spatial
Local Interactions
Taito Nakanishi (Grad. Sch. Int., Univ. Hiroshima)
乳がんの転移に関連するオントロジーグループに基づいた遺伝子相関ネットワーク解析による予後予測
Prognosis prediction of breast cancer by gene correlation network analysis based on Gene
Ontology terms involved in metastasis
Ayaka Yakushi1, Masahiro Sugimoto2, Takanori Sasaki1 (1Fac. Adv. Math. Sci., Meiji Univ., 2Tokyo Med.
Univ)
種内多型から テントウムシの模様形成メカニズムを予測する
Prediction of the pattern formation mechanism in ladybirds from polymorphism
Ryo Takeda (Grad.sch.Sci.,Univ.Osaka)
大腸菌走化性応答における細胞内シグナル伝達のデータ駆動によるモデル構築
Data-driven model construction of intracellular signal transduction in E. coli chemotaxis
response
Hiroto Tanaka, Yasuaki Kazuta, Hiroaki Kojima (Frontier Research Lab, Adv ICT Res Inst, NICT)
混雑下での分子の構造変化を考慮した反応拡散モデル
A reaction-diffusion model considering the conformational change of molecules and crowded
statesMasaki Okada1, Yuichi Togashi2,3 (1Grad. Sch. of Integr. Sci. for Life, Hiroshima Univ., 2Coll. Life Sci.,
Ritsumeikan Univ., 3Riken BDR)
細胞の遺伝子発現制御における学習過程
Learning processes in gene-expression regulation
Tomoyuki Yamaguchi (Research Institute, Nozaki Tokushukai Hospital)
細胞集団運動における界面張力の効果
Interface Tension Effect on Collective Cell Migration
Katsuyoshi Matsushita, Taiko Arakaki, Naoya Kamamoto, Maki Sudo, Koichi Fujimoto (Dep. Bio. Sci.,
Osaka Univ.)

非平衡・生体リズム／Nonequilibrium state & Biological rhythm
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筋芽細胞集団が示す位相欠陥と収縮性流れの幾何的制御
Geometric control of topological defects and contractile flow in confined myoblast cell
populations
Ryo Ienaga1, Yusuke Maeda1, Kazusa Beppu2 (1Grad. Sch. Sci.Phys., Univ. Kyushu, 2Applied Phys.,Univ. Aalto)– S127 –1Pos264

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ヒト iPS 細胞由来ニューロンの神経突起伸長過程における形態変化の数理解析とタンパク質凝集体発現の観察
Analysis of morphological change and observation of protein aggregations in thedevelopmental process of neurites of iPSC-derived neurons
Narumi Maeda1, Rio Hine1, Yudai Kitayama2, Yusuke Shibasaki1, Yuka Shirakawa3, Minoru Saito1,2,3(1Grad. Sch. of Integ. Bas. Sci., Nihon Univ., 2Coll. Hum. Sci., Nihon Univ., 3Nat. Inst., Coll. Hum. Sci.,
Nihon Univ.)
解糖系の振動現象に及ぼす飢餓処理の影響
Effect of starvation on the glycolytic oscillation in yeast cells
Keiya Goto1, Seiji Hatano1, Noboru Nagata1, Yutetsu Kuruma2, Masayuki Imai1 (1Grad. Sch. Sci.,
Tohoku Univ., 2Japan Agency for Marine-Earth Science & Technology)
Neuro2a 細胞の神経突起伸長過程における形態変化のリアルタイム数理解析
Real-time mathematical analysis of morphological change in the developmental process ofneurites of Neuro2a cells
Rio Hine1, Narumi Maeda1, Yudai Kitayama2, Yusuke Shibasaki3, Yuka Shirakawa3, Minoru Saito1,2,3(1Grad. Sch. of Integ. Bas. Sci., Nihon Univ., 2Coll. Hum. Sci., Nihon Univ., 3Nat. Inst., Coll. Hum. Sci.,
Nihon Univ.)
結合 BZ 反応の系の光応答性とその同期現象
Photoresponsivity and synchronization of coupled BZ reaction systems
Ryota Yamazaki1, Sigeru Sakurazawa2 (1Grad. Sch., Future Univ. Hakodate, Systems Information
Science, 2Future Univ. Hakodate, School of systems information science, Department of complex andintelligent systems)
上皮細胞の集団運動とペアリング秩序転移
Collective motion and pairing order transition of confined epithelial cells
Kazuyuki Shigeta1, Kazusa Beppu1, Aya Tanaka2, Yusuke Maeda1 (1Dept. Phys. Kyushu Univ., 2NTT
BRL, BMC)

計測／Measurements
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補償光学系と機械学習を用いて 1 分子輝点の 3 次元座標を精度良く計測する方法のシミュレーション研究
A simulation study to measure precisely three-dimensional coordinates of single molecule
images using adaptive optics and machine learning
Xiang Zhou, Yuma Ito, Makio Tokunaga (Sch. Life Sci. Tech., Tokyo Tech)
細胞内ナノドメインにおける分子ダイナミクスの精密な測定を可能にする一粒子追跡手法の開発
A novel single-particle tracking system for precise measurement of molecular dynamics inintracellular nanodomains
Shinkuro Kobayashi, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose (Grad. Sch. Med., Univ.
Tokyo)
Live prediction with image-based deep learning accesses temporal variability of single-celltranscriptomic states
Tobias Frick1,2, Katsuyuki Shiroguchi2 (1Osaka University, Graduate School of Frontier Biosciences(FBS), 2RIKEN Center for Biosystems Dynamics Research (BDR))
聴覚の末梢器官である内耳蝸牛の感覚上皮振動に含まれる直流動作の検出と分析
Analyses of the sound-evoked nanoscale offset motion in the cochlea of the inner ear
Takeru Ota1, Hiroshi Hibino1,2 (1Grad. Sch. Med., Univ. Osaka, 2AMED-CREST, AMED`)– S128 –1Pos273

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気液界面を用いた細胞メカニクス解析技術の開発
Development of gas-liquid interface-based cell mechanics analysis technology
Masaki Moriyama1, Naoya Ishizawa1, Ryo Kobayashi1, Seri Hayashi1, Makiko Takubo1,
Kaede Yokoyama1, Masataka Murakami1, Tetsuro Hoshino1, Akio Iwasa1, Masafumi Mimura1,
Hirohide Murai2, Taichi Nakamura2, Kiyoshi Nozaki1, Shuhei Tanaka1 (1Nikon Corporation, 2Nikon
Systems Inc.)
ラマンイメージングによる老化細胞のラベルフリー検出
Label-free detection of senescent cells by Raman imaging
Hiroko Kodama1, Ren Shibuya2, Shinji Kajimoto1,2,3, Takakazu Nakabayashi1,2 (1Faculty of
Pharmaceutical Sciences, Tohoku Univ., 2Graduate School of Pharmaceutical Sciences, Tohoku Univ.,
3JST PRESTO)
多様体学習と機械学習の外力下での細胞運動ダイナミクスへの適用
Manifold and machine learning techniques applied to cell movement dynamics under external
forcesHiroshi Fujisaki1, Kenta Odagiri2, Hiromichi Suetani3, Hiroya Takada1, Rei Ogawa1 (1Nippon Medical
School, 2Senshu Univ., 3Oita Univ.)
ソリッドステートナノポアによる H2A.B ヌクレオソームの構造安定性に関する研究
A study on the structural dynamics of the nucleosome containing H2A.B using solid-state
nanopores
Hikaru Nozawa1, Hirohito Yamazaki1, Ryo Iizuka1, Rina Hirano1,2, Tomoya Kujirai2,3,
Hitoshi Kurumizaka1,2, Sotaro Uemura1 (1Department of Biological Sciences, Graduate School of
Science, The University of Tokyo, 2Institute for Quantitative Biosciences, The University of Tokyo,
3RIKEN Center for Biosystems Dynamics Research.)
ナノポア計測による CALHM2 チャネルダイナミクスの解明
Investigation of CALHM2 Channel Dynamics using Nanopore measurement
Sotaro Nakamura, Hirohito Yamazaki, Wataru Shihoya, Osamu Nureki, Sotaro Uemura (Department of
Biological Sciences, The University of Tokyo)
赤外超解像顕微鏡による爪ケラチンタンパク質の分布・配向観察IR super-resolution imaging of keratin proteins in human nails based on non-linear opticalprocess
Hirona Takahashi, Tetsuya Ida, Kohei Katayama, Makoto Sakai (Faculty of Sci., Okayama Univ. of Sci.)
近赤外光検出が可能な微弱光検出器の現状
Current status of low-light photodetectors capable of detecting near-infrared lightAtsuhito Fukasawa1, Minako Hirano2, Toru Ide2, Hiroaki Yokota3 (1Hamamatsu Photonics K.K., 2Grad.
Sch. Interdiscip. Sci. Eng. Health Sci., Okayama Univ., 3Grad. Sch. Creation Photon Indust.)
表面増強ラマン分光を用いたジペプチド繰り返し配列を有するペプチドの液-液相分離液滴の計測
Surface Enhanced Raman Spectroscopy of liquid-liquid phase separation droplets consistingof dipeptide repeats
Yui Yamazaki1, Masayuki Fujiwara2, Ryo Kato2, Kohsuke Kanekura3, Taka-aki Yano2, Yuhei Hayamizu1(1Dept. of Mat. Sci. and Eng., Tokyo Tech, 2pLED, Tokushima Univ., 3Dept. of Molecular pathology,
Tokyo Medical Univ.)
CRISPR-Cas13 を用いたデュアルプローブシステムおよび液液相分離濃縮による RNA の高感度
1 分子計測Sensitive CRISPR-Cas13 mediated digital bioassay of RNA with dual probe system andenrichment by liquid-liquid phase separation
Yutaro Ii, Yoshihiro Minagawa, Hiroyuki Noji (Dept. Appl. Chem., Grad. Sch. Eng., Univ.Tokyo)– S129 –バイオイメージング／Bioimaging
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高速原子間力顕微鏡で観察されたミオシン V の歩行運動の隠れマルコフモデル解析
Hidden Markov model analysis of myosin V walking observed by high-speed atomic force
microscopy
Sotaro Fuchigami1, Yasuhiro Matsunaga2, Shoji Takada1 (1Grad. Sch. of Science, Kyoto Univ., 2Grad.
Sch. Sci. Eng., Saitama Univ.)(1SEP-6) Centromere-kinetochore structures revealed by 12x modified expansion microscopy
Yasuhiro Hirano1, Aussie Suzuki2, Yasushi Hiraoka1, Tatsuo Fukagawa1 (1Graduate School of Frontier
Biosciences, Osaka University, 2McArdle Laboratory for Cancer Research, University of WisconsinMadison)
Fluorescence polarization light-sheet microscopy for studying 3D molecular architectures in vivo
Tomomi Tani (Biomedical Research Institute, National Institute of Adavnced Industrial Science andTechnology)
細胞分化に伴うクロマチン構造における状態特異的なヒストン動態の 1 分子イメージング
Single-molecule analysis of state-specific histone mobility in chromatin subcompartments
during cellular differentiation
Masanori Hirose, Yuma Ito, Makio Tokunaga (Sch. Life Sci. Tech., Tokyo Tech)
Alphafold2 による遺伝子にコードされた FRET 型カルシウム指示薬の設計
Alphafold2-assisted design of a genetically-encoded FRET-based calcium indicator
Shinya Sakai1, Kei-ichi Okazaki2, Tomoki Matsuda3, Takeharu Nagai3 (1Graduate School of Frontier
Biosciences, Osaka University, Japan,, 2Research Center for Computational Science, Institute for
Molecular Science, Japan, 3SANKEN, Osaka University, Japan)
細胞性粘菌における c-di-GMP シグナルの解析
Fluorescence imaging of cyclic di-GMP signal in Dictyostelium discoideum
Hayato Ide, Yusuke Morimoto (Grad. Sch. Comp. Sci. and Sys. Eng., Kyushu Inst. Tech.)(3SAA-6) Size determination of cytoplasmic condensates of optineurin using spatial image
correlation spectroscopy (SICS)
Yuta Hamada1, Masataka Kinjo2, Akira Kitamura2 (1Grad. Sch. Sci. of Life Sci., Hokkaido Univ., 2Fac.
of Adv. Life Sci., Hokkaido Univ)(3SAA-4) Morphological Analysis of Hydrogel Induced Cancer Stem Cells in Synovial Sarcoma
Model Cells
Zannatul Ferdous1, Masumi Tsuda1,3,4, Jean-Emmanuel Clément3, Jian Ping Gong1,3,6,
Shinya Tanaka3,4,6, Tamiki Komatsuzaki2,3,5, Koji Tabata2 (1Graduate School of Life Science, Hokkaido
University, 2Research Center of Mathematics for Social Creativity, Research Institute for Electronic
Science, Hokkaido University, Sapporo, Japan, 3Institute for Chemical Reaction Design and Discovery(WPI-ICReDD), Hokkaido University, Sapporo, Japan, 4Department of Cancer Pathology, Hokkaido
University Faculty of Medicine, Sapporo, 5Graduate School of Chemical Sciences and Engineering,
Hokkaido University, Sapporo, Japan, 6Global Station for Soft Matter, Global Institution for
Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan)
細胞内ストレス顆粒の近赤外蛍光・ラマンイメージング：細胞固定化の相分離液滴への影響
Near-infrared fluorescence and Raman imaging of intracellular stress granules: Effects of cell
fixation on droplets formed by LLPS
Ren Shibuya1, Shinji Kajimoto1,2, Tetsuro Ariyoshi3,4, Yasushi Okada3,4, Takakazu Nakabayashi1(1Grad. Sch. Pharm. Sci., Tohoku Univ., 2JST PRESTO, 3RIKEN BDR, 4Grad. Sch. Med., Univ. Tokyo)– S130 –1Pos291

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情報理論を使ったラマン画像に含まれる化学情報と形態情報の関係性の定量
Quantification of the relationship between chemical and spatial information in Raman images
using information theory
Ryoya Kondo1, James Nicholas Taylor2, Yuta Mizuno1,2,3, Jean-Emmanuel Clement2,3,
Katsumasa Fujita4, Yoshinori Harada5, Tamiki Komatsuzaki1,2,3 (1Grad. Chem. Sci. Eng., Hokkaido
Univ., 2Res. Inst. Electr. Sci., Hokkaido Univ., 3WPI-ICReDD, Hokkaido Univ., 4Grad. Eng., Osaka Univ.,
5Kyoto Pref. Univ. Med.)
シグナル伝達反応進行過程における細胞膜上受容体動態の変化
Oligomerization and dynamics of receptor molecules during the signaling process
Hideaki Yoshimura, Takeaki Ozawa (Sch. Sci., Univ. Tokyo)
デュアルコム干渉計を用いた細胞膜電位のラベルフリー検出
Label-free detection of membrane potential using dual-comb interferometry
Satoshi Araoka1,3, Yusuke Takashima2, Yoshiki Naoi2,3, Akira Emoto3, Kazumichi Yoshii3,
Masatake Akutagawa2, Hiroki Takanari3 (1Graduate School of Sciences and Technology for Innovation,
Tokushima University, 2Graduate School of Technology, Industrial and Social Science, University ofTokushima, 3Institute of Post-LED Photonics, University of Tokushima)
脂質、ヌクレオチド依存的 Prx 高分子量複合体形成メカニズムの解明
Study on the formation mechanism of peroxiredoxin high molecular weight complex with lipid
and nucleotide
Ryusei Yamada1, Hiroki Konno2 (1Grad. Sch. of Nat. Sci. & Technol., Kanazawa University, 2WPI Nano
Life Sci. Inst. (WPI-NanoLSI), Kanazawa Univ)
イメージプロセッシングによる細胞内小胞輸送の 3 次元トラッキングデータ解析の自動化に関する研究
An automatic detection and tracking method for the 3D reconstruction of vesicle movement ina living cell
Seohyun Lee1, Hyuno Kim2, Hideo Higuchi3 (1Institute for quantitative biosciences, The University ofTokyo, 2Institute of Industrial Science, The University of Tokyo, 3Graduate School of Science, The
University of Tokyo)
機械学習を駆使して高速 AFM 画像から細胞骨格ネットワーク構造の再構成
Machine learning-guided reconstruction of cytoskeleton network from Live-cell AFM Images
Kanaki Kiku1, Shigehiro Yoshimura1, Skibbe Henrik2, Naoki Honda3 (1Graduate School of Biostudies,
Kyoto University, Japan, 2Brain Image Analysis Unit, RIKEN Center for Brain Science, Wako, Japan,
3Graduate School of Integrated Sciences for Life, Hiroshima University, Japan)
ランダムドメイン挿入法を用いた FRET 型植物ホルモンセンサーのスクリーニング
Screening of FRET-type plant hormone sensor using Random domain insertion method
Ami Nakano (Grad. Sch. Sci. Eng., Saitama Univ.)
寒天培地上での海洋微生物の構造色の出現と発達のタイムラプス観察
Timelapse observation of the emergence and development of structural color of a marine
bacterium on agar plates
Mikiko Tsudome, Shigeru Deguchi (JAMSTEC)
生体内高感度シングルショット 3D 温度イメージング技術の開発
Sensitive single-shot 3D temperature imaging in vivo
Haruka Maeoka1, Ryuji Igarashi2, Shin Usuki3, Takuma Sugi1 (1Program of Biomedical Science,
Graduate School of Integrated Sciences for Life, Hiroshima University, 2Quantum Science andTechnology Organization, 3Research Institute of Electronics, Shizuoka University)
Kilohertz imaging of intracellular heat diffusion with a genetically encoded temperature indicator
Kai Lu1, Tetsuichi Wazawa1, Joe Sakamoto3, Cong Quang Vu1,2, Masahiro Nakano1, Yasuhiro Kamei3,
Takeharu Nagai1,2 (1SANKEN, Osaka Univ., 2Graduate School of Frontier Biosciences, Osaka Univ.,
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従来の超解像用、生理機能用蛍光指示薬による生理機能超解像イメージング法
Functional super-resolution (fSR) imaging with conventional SR and functional fluorescentindicators
Ryohei Noma1, Satoshi Hara1, Tomoki Matsuda1, Tetsuichi Wazawa1, Takashi Washio1,2,Takeharu Nagai1,2 (1SANKEN (The Institute of Scientific and Industrial Research), Osaka University,
Japan, 2Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research
Initiatives, Osaka University, Japan)
長期間ライブイメージングを可能にする光損傷を軽減する撮影条件の最適化
Optimization of image acquisition methods to reduce photodamage for long-term live-imaging
Go Shioi1, Tomonobu M Watanabe1, Junichi Kaneshiro1, Yusuke Azuma2, Shuichi Onami2 (1Laboratory
for Comprehensive Bioimaging, RIKEN Center for Biosystems Dynamics Research, 2Laboratory for
Developmental Dynamics, RIKEN Center for Biosystems Dynamics Research)
1 分子動態と局在による機能的クロマチン-RNA polymerase II 相互作用の統合解析
An integrated analysis of functional chromatin-RNA polymerase II interaction using singlemolecule dynamics and localization
Yuma Ito, Makio Tokunaga (Sch. Life Sci. Tech., Tokyo Tech)
クライオ電子線トモグラフィー法による糸状仮足中のアクチン繊維上ファシンのサブトモグラ
ム平均化
Subtomogram Averaging of Fascin on Actin Filaments in Filopodia by Cryo-Electron
Tomography
Kaoru Mitsuoka1, Naoko Kajimura1, Takuo Yasunaga2 (1Research Center for Ultra-High Voltage EM,
Osaka Univ., 2Grad. Sch. Comp. Sci. Syst. Eng., KIT)
Gloeobacter violaceus の顕微分光イメージング
Microimaging of Gloeobacter violaceus
Kento Hashimoto1, Reo Minami1, Akio Murakami2, Mamoru Nango3, Mitsuru Sugisaki3,4 (1Grad. Sch.
Sci., Osaka City University, 2Grad. Sch. Sci., Kobe University, 3Grad. Sch. Sci., Osaka Metropolitan
University, 4NITEP, Osaka Metropolitan University)
骨格アニメーション法を活用したタンパク質構造変化の検証法
Utilizing skeletal animation for understanding structural change of proteins
Yutaka Ueno (Artificial Intelligence Research Center, AIST)

バイオエンジニアリング／Bioengineering
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CRISPR 関連タンパク質によるプログラム可能な哺乳類細胞翻訳調節器
Programmable mammalian translational modulators by CRISPR-associated proteinsShunsuke Kawasaki, Takeru Kuwabara, Hirohide Saito (Center for iPS Cell Research and Application,
Kyoto University)
カップ型微小電極を用いた非接着細胞表面分子計測技術の開発
Development of a technology to detect surface molecules on non-adherent cells by using Cupshaped microelectrodes
Taro Sasaki1,2, Kohki Uchiyama1,2, Tomoyuki Kamata3, Dai Kato3, Naoshi Kojima3, Shohei Yamamura3,
Hyonchol Kim1,2 (1Cell. Mol. Biotechnol. Res. Inst., AIST, 2Grad. Sch. Eng., Tokyo Univ. Agric. Technol,
3Health Med. Res. Inst., AIST)
3D DNA nanostructure-based assembled structures toward a construction of chromatin-likeheterogeneous system
Hong Xuan Chai1, Masahiro Takinoue2 (1Department of Life Science and Technology, School of Life
Science and Technology, Tokyo Institute of Technology, 2Department of Computer Science, School ofComputing, Tokyo Institute of Technology)– S132 –1Pos310

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DNA 増幅を動力源とするナノモーターの設計と評価
Design and evaluation of nanomotors powered by DNA amplification
Riku Yoshino1, Richard James Archer1, Satoshi Murata1, Shinichiro Nomura1, Ibuki Kawamata1,2(1Grad. Sch. Eng., Univ. Tohoku, 2Fuc. Core Reserch, Univ Ochanomizu)
DNA を用いたシグナル伝達のための核酸生成回路の検証
Characterization of Nucleic Acid Generation Circuits for DNA-based Signal Transduction
Ken Komiya, Chizuru Noda (X-star, JAMSTEC)
リン脂質-タンパク質非対称膜小胞を用いた小胞分裂モデルの構築
Construction of vesicle fission model using asymmetric phospholipid-protein vesicles
Masato Suzuki (Facut. Sci. Tech., Gunma. Univ)
原子間力顕微鏡液中測定によるパパイン分子と DNA で被覆された単層カーボンナノチューブ との相互作用の pH の影響の研究
Effects of pH on interaction of papain and DNA wrapped single walled carbon nanotubes
studied by atomic force microscopy in fluid
Masaki Kitamura, Kazuo Umemura (Physics. Science. Tokyo university of science/ Japanese)
フェリチンに内包されたマグネタイトナノ粒子の高周波磁場による加熱
Heat production by magnetite nanoparticles encapsulated in ferritin under alternating magnetic
field
Kanamaru Tomoko1, Yuta Hayashi1, Hiroto Goshima1, Toshiki Higuchi1, Arun Kasimchetty1,
Shuji Kanamaru2, Hideyuki Yoshimura1 (1Meiji Univ., 2Tokyo Institute of Techinology)
Inhibitory effect of nucleotides on acetylcholinesterase activity and its microflow based actuationin human plasma
Deshwal Akshi1, Gill Arshdeep Kaur2, Nain Surajmal1, Patra Dr.Debabrata2, Maiti Subhabrata1 (1Indian
Institute of Science Education and Research Mohali, Punjab 140306 , India, 2Institute of Nano Scienceand Technology , Mohali, Punjab 140306)

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1Pos317無細胞合成を用いたタンパク質結晶化と構造解析
Protein crystallization and structure analaysis using cell-free protein synthesis
Satoshi Abe, Junko Tanaka, Mariko Kojima, Takafumi Ueno (Sch. Life Sci. Tech., Tokyo Tech.)
細胞内タンパク質結晶を用いた天然変性タンパク質の網羅的構造解析
Comprehensive structure analysis of intrinsically disordered protein using in-cell protein crystal
Mariko Kojima, Satoshi Abe, Takafumi Ueno (Sch. Life Sci. & Tech., Tokyo Tech)

その他／Miscellaneous topics
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大気圧温度制御プラズマによる植物細胞への直接タンパク質導入法の開発及び導入機構解明
Direct protein introduction into plant cells by a temperature controllable atmospheric-pressureplasma and elucidation of the mechanism
Yuki Yanagawa1,2, Yusuke Iijima3, Toshiki Aizawa3, Yuma Suenaga3, Akitoshi Okino3,
Ichiro Mitsuhara4 (1Grad. Sch. Hortic., Chiba Univ., 2CSRS, RIKEN, 3FIRST, Tokyo Inst. Tech., 4NIAS,
NARO)
新規カロテノプロテインの分離と構造解析―青色にもピンク色にもなるアスタキサンチン
Isolation and structure analysis of a novel marine sponge carotenoprotein
Momoko Ishida, Momose Kuroda, Suzuho Iseya, Yui Fujita, Satoko Matsunaga (N.I.T., Hakodate Col.)– S133 –1Pos320

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Construction of novel lipidomics platform combined of targeted and non-targeted analysis
Hideaki Kasahara, Yasuto Yokoi, Hideya Kuwabara, Tadahiro Hoshino (MITSUI KNOWLEDGE
INDUSTORY CO., LTD.)
ヒト角栓内部における脂質の不均一分布
Heterogeneous spatial distribution of lipid components in a follicular cast
Hitomi Matsushita1, Hiromitsu Nakazawa1, Noboru Ohta2, Taro Moriwaki2, Satoru Kato1 (1Grad. Sch.
SciTech., Kwansei Gakuin Univ., 2JASRI/SPring-8)
変分オートエンコーダを用いた下顎骨形態の定量化
A method for morphological feature extraction based on variational auto-encoder: an application
to mandible shape
Masato Tsutsumi1, Nen Saito2,3,4, Daisuke Koyabu5,6, Chikara Furusawa4,7 (1Dept. of Physics, Grad.
Sch. Sci., The Univ. of Tokyo, 2Grad. Sch. Integr. Sci. for Life, Hiroshima Univ., 3ExCELLS, NIBB, 4UBI,The Univ. of Tokyo, 5Res. and Dev. Center for Precision Med., Tsukuba Univ., 6Jockey Club College of
Veterinary Medicine and Life Sciences, City University of Hong Kong, 7BDR, RIKEN)
Evaluation of the Potent SARS-CoV-2 Main Protease Inhibitors using LB-PaCS-MD/FMO
Technique
Kowit Hengphasatporn, Ryuhei Harada, Yasuteru Shigeta (Center for Computational Sciences, Univ.
Tsukuba)
Flory-Huggins 理論を用いた 3 成分系における相分離挙動の解析
Analysis of phase separation behavior in three-component systems based on the Flory-Huggins
theoryNaoki Iso, Takahiro Sakaue, Yuki Norizoe (Aoyama Gakuin University)
多孔質ハイドロゲル固体試料中における紫膜積層に適した孔サイズ分布
Pore size distributions related to spontaneous purple membrane stacking in porous hydrogels
Yasunori Yokoyama1,2, Morise Karasawa1, Kingo Takiguchi3, Hiroshi Takahashi4, Takashi Kikukawa5,
Masashi Sonoyama4,6,7, Koshi Takenaka1 (1Grad. Sch. Eng., Nagoya Univ., 2Natl. Inst. Tech., Hakodate
Coll., 3Grad. Sch. Sci., Nagoya Univ., 4Grad. Sch. Sci. Tech., Gunma Univ., 5Fac. Adv. Life Sci.,
Hokkaido Univ., 6GIAR, Gunma Univ., 7GUCFW, Gunma Univ.)
2 日目（9 月 29 日（木））／Day 2（Sep. 29 Thu.）

蛋白質：構造／Protein: Structure
2Pos001*

2Pos002*

2Pos003*

クライオ電子顕微鏡によるヒト LPA1 受容体の構造解析
Cryo-EM structure of Human Lysophosphatidic Acid Receptor 1
Hiroaki Akasaka, Tatsuki Tanaka, Fumiya Sano, Wataru Shihoya, Osamu Nureki (Grad. Sch. Sci., The
Univ. of Tokyo)
クライオ電子顕微鏡を用いたコレラ菌 Na+輸送性 NADH-ユビキノン酸化還元酵素の構造解明
Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae
Moe Ishikawa1, Jun-ichi Kishikawa2, Takahiro Masuya1, Masatoshi Murai1, Yuki Kitazumi1,
L. Nicole Butler3, Takayuki Kato2, Blanca Barquera3,4, Hideto Miyoshi1 (1Grad. Sch. Agri., Kyoto Univ./
Japanese, 2Inst. Prot. Res., Osaka Univ./ Japanese, 3Bio. Sci., RPI/ USA, 4CBIS, RIP/ USA)
(3SFA-3) クライオ電子顕微鏡による高分解能解析によって明らかになってきた二成分毒素の膜透過機構(3SFA-3) High-resolution Cryo-EM analysis reveals the mechanism of binary toxin translocation
Tomohito Yamada1, Yukihiko Sugita2,3, Takeshi Noda2, Hideaki Tsuge1 (1Graduate School of Life
Science, Kyoto Sangyo University, 2Laboratory of Ultrastructural Virology, Institute for Life and Medical
Sciences, Kyoto University, 3Hakubi Center for Advanced Research, Kyoto University)– S134 –2Pos004

2Pos005*

2Pos006*

2Pos007

2Pos008*

2Pos009*

2Pos010

2Pos011タンパク質間相互作用阻害を機序とする抗新型コロナウイルス薬の創出
Screening for new types of coronavirus inhibitors that block protein-protein interaction
Ryusei Hamajima1, Haruka Takagi1, Takeshi Tenno1, Youichi Suzuki2, Hong Wu2, Hidekazu Hiroaki1(1Grad. Sch. Pharm. Sci., Nagoya Univ., 2School of Medicine, Osaka Medical and Pharmaceutical
University)
クライオ電子顕微鏡によるヒト由来メラトニン受容体シグナル伝達複合体の立体構造解析
Cryo-EM structure of the human MT1–Gi signaling complex
Hiroyuki Okamoto1, Hirotake Miyauchi1, Asuka Inoue2, Francesco Raimondi3, Hirokazu Tsujimoto4,
Tsukasa Kusakizako1, Wataru Shihoya1, Keitaro Yamashita1,5, Ryoji Suno6, Norimichi Nomura4,
Takuya Kobayashi6, So Iwata4,7, Tomohiro Nishizawa8, Osamu Nureki1 (1Graduate School of Science,
The University of Tokyo., 2Graduate School of Pharmaceutical Sciences, Tohoku University.,
3Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore., 4Graduate School of Medicine, Kyoto
University., 5MRC Laboratory of Molecular Biology., 6Department of Medical Chemistry, Kansai
Medical University., 7RIKEN SPring-8 Center., 8Graduate School of Medical Life Science, Yokohama
City University.)
FlhAc の高速原子間力顕微鏡画像の解析
Analysis of High Speed Atomic Force Microscopy Image of FlhAc
Riku Osawa1, Naoya Terahara2, Noriyuki Kodera3, Katsumi Imada4, Tohru Minamino5, Akio Kitao1(1Sch. Life Science and Technology, Tokyo Tech, 2Dep. Physics Faculty of Science and Engineering, Chuo
Univ, 3Bio-AFM Frontier Research Center, Kanazawa Univ, 4Dep. Macromolecular Science, Grad. Sch.
Science, Osaka Univ, 5Grad. Sch. Frontier Biosciences, Osaka Univ)
デングウイルス由来 RNA 依存性 RNA ポリメラーゼと天然物ライブラリーから得られたその阻害剤との複合体の立体構造解析
Structure analysis of the dengue viral RNA-dependent RNA polymerase in complex with its
inhibitor obtained from marine natural products
Nami Hosoi1, Haruka Nakatani2, Lakkana Thaveepornkul3, Arisa Suto4, Naoki Sakai5,6,
Hiroaki Matsuura6, Masaki Yamamoto6, Takashi Matsui7,8, Yoshio Kodera7,8, Sarin Chimnaronk3,
Ryuichi Sakai2, Takeshi Yokoyama1, Yoshikazu Tanaka1 (1Grad. Sch. Life Sci., Tohoku Univ., 2Grad. Sch.
Fisheries Sci., Hokkaido Univ., 3The Laboratory of RNA Biology, Institute of Molecular Biosciences,
Mahidol University, 4Grad. Sch. Sci., Kitasato Univ., 5Strut. Biol. Div. JASRI, 6Life Sci. Res. Infra. Gr.,RIKEN RSC, 7Sch. Sci., Kitasato Univ., 8Cent. Disease Proteomics, Kitasato Univ.)
フェレドキシン-NADP+還元酵素の中性子結晶構造解析
Neutron crystallographic analysis of ferredoxin-NADP+ reductase
Midori Uenaka1,2, Yusuke Ohnishi1, Hideaki Tanaka1,2, Genji Kurisu1,2 (1IPR., Osaka Univ., 2Grad. Sch.
Sci., Osaka Univ.)
クライオ電子顕微鏡を用いたビタミン C トランスポーター SVCT1 の構造解析
Cryo-EM structures of vitamin C transporter SVCT1
Takaaki Kobayashi, Hiroto Shimada, Fumiya Sano, Tsukasa Kusakizako, Osamu Nureki (Dept. Biol.
Sci., Grad. Sch. Sci., Univ. Tokyo)
赤色蛍光タンパク質の単一復帰変異による赤色蛍光消失の構造基盤
Structural basis of the loss of red fluorescence by single back mutation of an artificial red
fluorescent protein
Shiho Otsubo1, Hiromi Imamura2, Norihiro Takekawa1, Katsumi Imada1 (1Grad. Sch. Sci., Osaka Univ.,
2Grad. Sch. Biost., Kyoto Univ.)
MD シミュレーションによる LIM2 ドメインの構造解析
Structural analysis of Lim2 domain by MD simulation
Motokuni Nakajima1, Yoh Noguchi1,3, Hironao Yamada2,3, Ryota Morikawa1, Masako Takasu1,
Yukiko K. Hayashi4 (1Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2Sch. of Pharm., Tokyo Univ.
of Pharm. and Life Sci., 3The Inst.of Statist. Math., 4Tokyo Med. Univ.)– S135 –2Pos012

2Pos013

2Pos014

2Pos015

2Pos016

2Pos017

2Pos018

2Pos019

2Pos020

2Pos021

2Pos022

尿素とトリエチルアミン N-オキシドが KaiC の ATPase 活性に及ぼす影響
Effects of urea and trimethylamine N-oxide on the ATPase activity of KaiC
Nanaka Hara1, Keita Mitsuhashi2, Haruka Horiuchi3, Masahiro Miyamoto1, Ayumi Masuda1,
Soichiro Kitazawa3, Ryo Kitahara3 (1Graduate School of Pharmaceutical Sciences, Ritsumeikan
University, 2Graduate School of Life Sciences, Ritsumeikan University, 3College of Pharmaceutical
Sciences, Ritsumeikan University)
原子分解能でみた概日時計の朝夕昼夜
Visualizing a Day of Circadian Clock at Atomic Resolution
Yoshihiko Furuike1,2, Atsushi Mukaiyama1,2, Eiki Yamashita3, Takao Kondo4, Shuji Akiyama1,2(1Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science (IMS),
2The Graduate University for Advanced Studies (SOKENDAI), 3Institute for Protein Research (IPR),
Osaka University, 4Graduate School of Science, Nagoya University)
分子動力学シミュレーションを活用した VHH-抗原複合体のアンサンブルドッキング
Ensemble Docking of VHH-Antigen Complexes using Molecular Dynamics Simulations
Kohei Yamaguchi, Ren Higashida, Yasuhiro Matsunaga (Grad. Sch. Sci. Eng., Saitama Univ.)
Structure and stability analysis of Cry j 7, an antimicrobial peptide from Japanese cedar thatcauses the pollen-food allergic syndrome
Jingkang Zheng, Tomona Iizuka, Hiroyuki Kumeta, Yasuhiro Kumaki, Ami Hanaoka,
Ichiho Yoshikawa, Yurie Nakajima, Soma Ishihara, Tomoyasu Aizawa (Grad. Sch. Life Sci., Hokkaido
Univ.)
細菌由来グルカンスクラーゼのアクセプター特異性に関連するループ構造
The loop structure responsible to the acceptor specificity of bacterial glucansucrase
Takafumi Inoue, Hideyuki Komatsu (Dept. of Bioscience and Bioinfomatics, Kyushu Inst. Tech.)
構造解析に向けたヒト免疫不全ウイルス 2（HIV-2）エンベロープ糖タンパク質の調製
Preparation of human immunodeficiency virus type-2 (HIV-2) envelope glycoprotein forstructure analysis
Yuki Anraku1, Shunsuke Kita1, Hideo Fukuhara1, Haruka Kawabata1, Takaki Akiyama1, Simon Davis2,
Atsushi Furukawa1, Thushan I. de Silva2, James E. Robinson3, Yuguang Zhao2, E. Yvonne Jones2,
David Stuart2, Juha T Huiskonen2, Sarah Rowland-Jones2, Katsumi Maenaka1 (1Fac. Pharm. Sci., Univ.
Hokkaido, 2Univ. Oxford, 3Univ. Tulane)
粗視化モデルによる微小管の安定性の理論的研究
Theoretical study of stability of microtubules by a coarse-grained modelAyasa Kurahashi, Hiro Takeda, Kazutomo Kawaguchi, Hidemi Nagao (Grad. Sch. Nat. Sci. Tech.,Kanazawa Univ.)
X 線小角散乱測定を用いたクラミドモナス由来クリプトクロムの溶液構造解析
Structural analyses of the animal-like cryptochrome from Chlamydomonas reinhardtii by small
angle X-ray scattering
Soma Matsuda, Satoshi Nagao, Daichi Yamada, Minoru Kubo (Grad. Sch. Sci., Univ. Hyogo)
蛋白質天然変性領域を模倣する生理活性化合物の探索
Search of bioactive compounds that imitate intrinsically disordered regions of proteins
Haruki Fukuyama1, Takuya Takahashi2, Kota Kasahara2 (1Grad. Sci. Life Sci., Ritsumeikan Univ., 2Coll.
Life Sci., Ritsumeikan Univ.)
Effect of a narrowest clamp of binary toxin on cell toxicity
Yuto Uchida1, Toru Yoshida2, Tomohito Yamada1, Hideaki Tsuge1 (1Graduate of Life Scienc, kyoto
Sangyo University, 2Fac. Sci., Japan Women's Univ.)
β シートにおける隣接ストランド間でのペア特異的 Cα 距離の解析
Pair-specific analysis of Cα distances between adjacent strands in β-sheets
Hiromi Suzuki (Sch. Agri., Meiji Univ.)– S136 –2Pos023

2Pos024

分子動力学シミュレーションによる凝集性を有するペプチドの密度依存性に着目した構造分布解析
Distribution and structure analysis of fibril-forming peptides focusing on concentration
dependency by molecular dynamics simulation
Yoshitake Sakae1,2, Takeshi Kawasaki2, Yuko Okamoto3 (1RIST, 2Dep. Phys., Nagoya Univ., 3Info. andComm., Naogya Univ.)
An extended bound-water network and hydrophobic hydration determine the activity of
microbial antifreeze protein
Hidemasa Kondo1,2, N. M.‑Mofiz Uddin Khan2,3, Tatsuya Arai4, Sakae Tsuda4,5,6, Yasushi Ohyama1(1Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology(AIST), 2Graduate School of Life Science, Hokkaido University, 3Department of Chemistry, Dhaka
University of Engineering and Technology, Gazipur, 4Graduate School of Frontier Sciences, The
University of Tokyo, 5OPERANDO Open Innovation Laboratory, National Institute of Advanced
Industrial Science and Technology (AIST), 6Faculty of Advanced Life Science, Hokkaido University)

蛋白質：構造機能相関／Protein: Structure & Function
2Pos025

2Pos026*

2Pos027*

2Pos028*

2Pos029

2Pos030

Gly-kink 導入 β バレルナノポアを用いた単一分子検出
Single-molecule detection using β-barrel nanopore with Gly-kink
Ikuro Mizoguchi1, Masataka Usami1, Keisuke Shimizu1, Shuhei Yoshida2, Yoshio Hamada2,
Yuto Suzuki3, Yuzuha Araki3, Kenji Usui2, Izuru Kawamura3, Ryuji Kawano1 (1Department of
Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2Faculty of Frontiers ofInnovative Research in Science and Technology, Konan University, 3Graduate School of Engineering
Science, Yokohama National University)(2SDP-5) Structural basis of the significant metal-histidine coordination in E. coli RNase HI
Zengwei Liao1, Takuji Oyama2, Yumi Kitagawa3, Katsuo Katayanagi4, Kosuke Morikawa5,
Masayuki Oda3 (1Grad. Sch. Agri. and Life Sci., the Univ. of Tokyo, 2Faculty of Life and Environ. Sci.,
Univ. of Yamanashi, 3Grad. Sch. Life Environ. Sci., Kyoto Pref. Univ., 4Grad. Sch. Integrated Sci. for Life,
Hiroshima Univ., 5Grad. Sch. Biostudies, Kyoto Univ.)
De novo ペプチドナノポアの無細胞合成へのアプローチ
Approaches to cell-free synthesis of de novo peptide nanopores
Shoko Fujita, Miyu Fukuda, Ikuro Mizoguchi, Ryuji Kawano (Department of Biotechnology and Life
Science, Tokyo University of Agriculture and Technology)
K48 結合型環状ユビキチン鎖の物性解析
Physical property analysis of cyclic K48-linked ubiquitin chains
Tomoki Sorada1, Daichi Morimoto1, Erik Walinda2, Kenji Sugase3 (1Grad. Sch. Eng., Univ. Kyoto,
2Grad. Sch. Med., Univ. Kyoto, 3Grad. Sch. Agr., Univ. Kyoto)
アミノ酸生産菌の呼吸鎖の拡張型超複合体の電子顕微鏡による観察と解析
Electron microscopic observation and analysis of extended supercomplexes of the respiratory
chain of amino acid-producing bacteria
Ayumi Moriyasu1, Tomoichirou Kusumoto1, Hiroko Takazaki2, Takuo Yasunaga1, Takayuki Kato2(1Grad. Sch. Comp. Sci. Syst. Eng., KIT, 2IPR, Univ. Osaka)
グルタミン酸脱水素酵素における補酵素結合経路のクライオ電子顕微鏡観察
Cofactor binding pathway in glutamate dehydrogenase studied using cryoTEM
Taiki Wakabayashi1,2, Mao Oide1,2, Takayuki Kato3, Masayoshi Nakasako1,2 (1Dept. Phys., Keio Univ.,
2RSC, RIKEN, 3Protein Inst., Osaka Univ.)– S137 –2Pos031*

2Pos032

2Pos033

2Pos034*

2Pos035

2Pos036

2Pos037*

2Pos038

2Pos039*

2Pos040*

In silico design of cross-reactive antibodies binding to SARS-CoV and SARS-CoV-2 spike RBDs
Yoshiki Yasuda1, Daisuke Kuroda2, Jiei Sasaki3, Makoto Nakakido1, Ryo Matsunaga1,
Hashiguchi Takao3, Kouhei Tsumoto1 (1Grad. Sch. Eng., The University of Tokyo, 2Research Center for
Drug and Vaccine development, National Institute of Infectious Diseases, 3Laboratory of Medical
Virology, Institute for Life and Medical Sciences, Kyoto University)
動的・静的構造解析による南極産好冷細菌由来グルコキナーゼの低温適応・高熱安定性機構の解明
X-ray crystallography and spin-labeling ESR reveal cold adaptation and high thermal stability
mechanism of cold-adapted glucokinase
Akane Yato1, Rio Asaka2, Hiroshi Sugimoto3, Keiichi Watanabe2, Masaki Horitani2 (1United Grad. Sch.
Agri. Sci., Kagoshima Univ., 2Agri., Saga Univ., 3SPring-8, RIKEN)
EPR 法による中温菌、好冷細菌由来複核 Mn 酵素の活性中心における微細構造変化の検出
EPR Spectroscopy Reveals the Differences of Active Site Structures for Di-Mn Enzymes from
Mesophilic and Psychrophilic Bacteria
Masaki Horitani1,2, Yuri Kasu1 (1Fac. Agric., Saga Univ., 2Unit. Grad. Sch. Agric. Sci., Kagoshima
Univ.)
FixL 二量体感覚領域のリガンド認識機構
Computational Study on the Ligand Discrimination of Dimeric Sensory Domain of FixL Protein
Tingting Wang, Takahisa Yamato (Graduate School of Science, Nagoya University)
QM/MM 法による C-メチル基転移酵素 Fur6 の反応機構解析
QM/MM study on the catalytic mechanism of the C-methyltransferase Fur6
Fan Zhao1, Tomohiro Noguchi1, Yoshitaka Moriwaki1, Tohru Terada1, Tomohisa Kuzuyama1,2,
Kentaro Shimizu1 (1Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo, 2CRIIM, Univ. of Tokyo)
CD28 結合と構造安定性に寄与する Grb2 のドメイン間相互作用
Interdomain interactions in Grb2 contribute to the conformational stability and CD28 binding
Saki Ochi, Momoka Iiyama, Masayuki Oda (Grad. Sch. Life Environ. Sci., Kyoto Pref. Univ.)
リョビュウイルスの核蛋白質 -RNA 複合体のクライオ電子顕微鏡構造
Cryo-EM structure of the nucleoprotein-RNA complex of a novel filovirus, Lloviu virus
Shang fan Hu1,2,3, Yoko Fujita-Fujiharu1,2,3, Yukihiko Sugita1,2,4, Lisa Wendt5, Yukiko Muramoto1,2,3,
Masahiro Nakano1,2,3, Thomas Hoenen5, Takeshi Noda1,2,3 (1Laboratory of Ultrastructural Virology,
Institute for Life and Medical Sciences, Kyoto University, 2Laboratory of Ultrastructural Virology,
Graduate School of Biostudies, Kyoto University, 3CREST, Japan Science and Technology Agency,
4Hakubi Center for Advanced Research, Kyoto University, 5Laboratory for Integrative Cell and Infection
Biology, Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut)
シトクロム P450 によるメチレンジオキシブリッジ形成の反応機構
Reaction mechanism of methylenedioxybridge formation by cytochrome P450
Kenshin Kondoh, Ryo Yonezawa, Eiichi Mizohata (Grad.Sch.Eng., Osaka Univ.)
ヒト stomatin SPFH ドメインのリン酸イオンに依存した線維状構造
The SPFH domain of human stomatin forms fibril-like assembly at high concentrations, whose
formation is promoted by phosphate ions
Koki Kataoka1, Shota Suzuki1, Takeshi Tenno1, Natsuko Goda1, Emi Hibino1, Atsunori Oshima1,2,3,
Hidekazu Hiroaki1,2 (1Grad. Sch. Pharm. Sci., Nagoya Univ., 2Cellular and Structural Physiology
Institute (CeSPI), 3iGCORE, Toaki National Higher Education and Research System)
天然変性タンパク質が引き起こす滑膜肉腫発生の新規メカニズム
A Novel Mechanism of Synovial Sarcoma Induced by Intrinsic Disordered Proteins
Kanami Takahashi1, Naoki Horikoshi2, Kazutoshi Tani3, Yohei Miyanoiri4, Noriyuki Kodera5,
Masahiro Nishimura2, Kohsuke Kato6, Satoshi Takenaka7, Hitoshi Kurumizaka2, Kenji Iwasaki8 (1Grad.
Sch. Sci. and Tech., Univ. of Tsukuba, 2IQB, Univ. of Tokyo, 3Grad. Sch. of Med., Mie Univ., 4IPR, Osaka
Univ., 5NanoLSI, Kanazawa Univ., 6Grad. Sch. of Comprehensive Human Sciences, Univ. of Tsukuba,
7Osaka International Cancer Inst. Hosp., 8TARA, Univ. of Tsukuba)– S138 –2Pos041

2Pos042*2Pos043

2Pos044

2Pos045

2Pos046

2Pos047

HSP40 結合による HSP70 の安定性への影響
HSP40 binding affects the stability of HSP70
Lisa Matsukura, Naoyuki Miyashita (Grad. Sch. BOST, KINDAI Univ.)
緑藻クラミドモナス由来シトクロム b 6 f 複合体のクライオ電子顕微鏡構造が示す Rieske 鉄硫黄
蛋白質の機能的構造変化
Cryo-EM structure of cytochrome b 6 f complex from Chlamydomonas reinhardtii reveals thefunctional domain movement of Rieske ISP
Hatsuki Tanabe1,2, Shinichiro Ozawa3, Akihiro Kawamoto1,2, Hideaki Tanaka1,2, Yuichiro Takahashi4,
Genji Kurisu1,2 (1IPR., Osaka Univ., 2Grad. Sch. Eng., Osaka Univ., 3IPSR., Okayama Univ., 4RIIS.,
Okayama Univ.)疾患関連変異のタンパク質構造上の三次元分布に基づく新規機能部位の探索
Search for undiscovered protein functional sites based on the spatial distribution of diseaseassociated missense variants
Chie Motono1,2, Atsushi Hijikata3, Takatsugu Hirokawa4,5, Kenichiro Imai1 (1Cell. Mol. Biotechnology
RI, AIST, 2CBBD-OIL, AIST, 3Sch.Life Sci., Tokyo Univ. Pharm. Life Sci., 4Faculty Med., Univ. of
Tsukuba, 5Transborder Med. Res. Center, Univ. of Tsukuba)
拡張アンサンブル法を用いた 3 次元ドメインスワッピング(3D-DS)の研究
3 Dimensional Domain Swapping (3D-DS) Studied by Advanced Molecular Dynamics
Simulation
Hiromitsu Shimoyama, Yasuteru Shigeta (CCS, Tsukuba Univ.)
構造に基づくキラターゼ CfbA のポルフィリン型基質選択性の理解
Structural insights into porphyrinoid substrate selectivity of chelatase CfbA
Shoko Ogawa1, Yuma Oyamada1, Masahide Hikita2, Takashi Fujishiro1 (1Dept. of Biochem. Mol. Biol.,Grad. Sch. Sci. Engineer., Saitama Univ. / Japanese, 2IMSS, KEK / Japanese)
Structure-function relationship of Zn finger domain in Heliorhodopsin
Manish Singh1, Kota Katayama1, Yuji Furutani1, Oded Béjà2, Rohit Ghai3, Hideki Kandori1 (1Nagoya
Institute of Technology (Japan), 2Technion –Israel Institute of Technology (Israel), 3Department of
Aquatic Microbial Ecology (Czech Republic))
Torque transmission of the F1-ATPase with an inelastic driveshaft
Shou Furuike, Yasushi Maki, Hideji Yoshida (Dept. of Phys. Osaka Med. Pharm. Univ.)

蛋白質：物性（安定性 折れたたみなど）／Protein: Property
2Pos048

2Pos049*

2Pos050*

環境変化によるタンパク質の構造変化を取り込んだ粗視化タンパク質モデル
An improved coarse grained protein model to include an environment-driven conformationalchangeTeppei Yamada1, Wataru Shinoda2 (1Graduate School of Natural Science, Okayama University,
2Research Institute for Interdisciplinary Science, Okayama University)
表面電荷改変抗体のコロイド安定性・結合親和性とその溶媒依存性の解析
Analysis of buffer-dependent colloidal stability and binding affinity of supercharged antibodies
Keisuke Kasahara1, Daisuke Kuroda2, Satoru Nagatoishi3, Kouhei Tsumoto1,3 (1Dept. Bioeng., Grad.
Sch. Eng., Univ. Tokyo, 2Res. Ctr. Drug Vaccine Dev., NIID, 3Inst. Med. Sci., Univ. Tokyo)(1SBA-3) タンパク質ケージ内における芳香環相互作用ネットワークの熱力学・分子動力学的解析(1SBA-3) Thermodynamic and Molecular Dynamic Analysis of Aromatic Interaction Networks
in Protein Cages
Yuki Hishikawa1, Noya Hiroki1, Asuka Asanuma1, Basudev Maity1, Satoru Nagatoishi2,
Kouhei Tsumoto2,3, Satoshi Abe1, Takafumi Ueno1 (1Sch. Life Sci. Technol., Tokyo Inst. Technol., 2Inst.
Med. Sci., Univ. Tokyo, 3Sch. Eng., Univ. Tokyo)– S139 –2Pos051

2Pos052

2Pos053

2Pos054

2Pos055

2Pos056

2Pos057*

2Pos058

2Pos059

2Pos060(1SAA-7) 蝶々型金ナノデバイスが可能にするタンパク質液液相分離過程の制御(1SAA-7) Control of protein condensation by butterfly-shaped gold nanodevices
Tomohiro Nobeyama1, Koji Takata2, Tatsuya Murakami2, Kentaro Shiraki1,2 (1Pure and Appli.Sci.,
Univ.Tsukuba, 2Grad. Sch. Sci. Toyama Pref. Univ)
6 M 塩化グアニジニウム中でアンフォールドした 3 ヘリックス・バンドル蛋白質の残存構造のH/D 交換 2 次元 NMR による研究
Residual structures in the unfolded state in a three-helix-bundle protein in 6 M guanidinium
chloride studied by H/D-exchange 2D NMR
Kunihiro Kuwajima1, Saeko Yanaka2, Maho Yagi-Utsumi2, Koichi Kato2 (1Grad. Sch. Sci., Univ. Tokyo,
2ExCELLS & IMS，NINS)
Isolation and characterization of a 200kDa fibroin precursor
Kok Sim Chan1, Kento Yonezawa2, Haruya Kajimoto1, Takehiro Sato3, Yoichi Yamazaki1,
Sachiko Toma-Fukai1, Hironari Kamikubo1,2 (11Division of Materials Science, Graduate School of
Science and Technology, Nara Institute of Science and Technology, 2Center for Digital Green-innovation,
Nara Institute of Science and Technology, 3Spiber Inc.)
スタフィロコッカル・ヌクレアーゼにおける、自発的フォールディングからリガンド誘導フォー
ルディングへの機構転移
How to shift the mechanisms from spontaneous folding to ligand-induced folding ofstaphylococcal nuclease?
Yujiro Mori1, Issei Suzuki2, Shingo Fukazawa2, Kosuke Maki1 (1Grad. Sch. Sci., Nagoya Univ., 2Sch.
Sci., Nagoya Univ.)
液-液相分離により形成されるドロップレット内部でのタンパク質及び RNA の分子ダイナミクス
Molecular dynamics of proteins and RNA within droplets formed by liquid-liquid phaseseparation
Fuga Watanabe1, Takuma Akimoto2, Eiji Yamamoto3 (1Grad. Sch. Sci. Tech., Keio Univ., 2Dept. Phys.,
Tokyo Univ. Sci., 3Dept. Syst. Des. Eng., Keio Univ.)
剪断応力がフィブロインナノファイバーに及ぼす影響
Effect of shear stress on fibroin nanofibers
Keita Iwasaki1, Kento Yonezawa1,2, Satoru Onishi1, Muneya Daidai1, Haruya Kajimoto1, Takehiro Sato3,
Yoichi Yamazaki1, Sachiko Toma-Fukai1, Hironari Kamikubo1,2 (1NAIST, MS, 2NAIST, CDG, 3Spiber Inc)神経変性疾患関連タンパク質 Ataxin-3 の液-液相分離と凝集ダイナミクスのポリ Q 鎖長依存性
PolyQ chain length dependence of liquid-liquid phase separation and aggregation dynamics ofa neurodegeneration-related protein ataxin-3
Uchu Matsuura1, Shinya Tahara1, Shinji Kajimoto1,2, Takakazu Nakabayashi1 (1Graduate School of
Pharmaceutical Sciences, Tohoku University, 2JST PRESTO, Japan.)
疾病関連 α-シヌクレイン変異体の構造およびダイナミクス特性
Structural and dynamical properties of the disease-related mutants of α-synuclein
Satoru Fujiwara1, Kai Nishikubo1, Kensuke Ikenaka2, César Aguirre2, Hideki Mochizuki2 (1Inst.
Quantum Life Science, QST, 2Grad. Sch. Medicine, Osaka Univ.)
統計力学モデルによるアポミオグロビンのフォールディング反応機構の予測
Folding mechanisms of apomyoglobin predicted by an extended statistical mechanical model
Koji Ooka1, Munehito Arai2,3 (1Col. Arts & Sci., Univ. Tokyo, 2Dept. Life Sci., Univ. Tokyo, 3Dept. Phys.,Univ. Tokyo)
コンタクト計算を厳密化した改良型統計力学モデルによるタンパク質フォールディング経路の予測
Predicting protein folding pathways using the statistical mechanical model modified withaccurate contact calculation
Runjing Liu1, Koji Ooka2, Munehito Arai1,3 (1Dept. Life Sci., Univ. Tokyo, 2Col. Arts & Sci., Univ.
Tokyo, 3Dept. Phys., Univ. Tokyo)– S140 –2Pos061

2Pos062

2Pos063

AlphaFold は条件付きでフォールドする天然変性タンパク質・天然変性領域（ProS）の構造をどのように予測したか
How AlphaFold predicts conditionally-foldable segments in intrinsically disordered proteins
Koya Sakuma1, Hiroto Anbo2, Satoshi Fukuchi2, Motonori Ota1 (1Grad. Sch. Informatics, Nagoya Univ.,
2Faculty of Engineering, Maebashi Inst. of Technology)
Liquid-liquid phase separation and amyloid formation of Sup35 from four different yeast species
Yumiko Ohhashi1, Suguru Nishinami2, Kentaro Shiraki2, Eri Chatani1 (1Grad. Sch of Sci., Kobe Univ.,
2Inst. Appl. Phys., Univ. of Tsukuba)
トランスサイレチン断片のアミロイド線維形成
Amyloid fibril formation of transthyretin fragments
Keisuke Yuzu1, Misato Matsumura1, Naoki Yamamoto2, Masatomo So3, Keiichi Yamaguchi4,
Yuji Goto4, Eri Chatani1 (1Grad. Sch. Sci., Kobe Univ., 2Fac. Med., Jichi Med. Univ., 3Inst. Protein Res.,
Osaka Univ., 4Grad. Sch. Eng., Osaka Univ.)

蛋白質：機能（反応機構 生物活性など）／Protein: Function
2Pos064*

2Pos065

2Pos066

2Pos067

2Pos068

β アレスチンの新規 PIP2 結合サイトとその機能
Novel PIP2 binding site of βarrestin and its function
Ritsuki Kuramoto, Tatsuya Ikuta, Koki Kawakami, Asuka Inoue (Graduate School of Pharmaceutical
Sciences, Tohoku University)
クチナーゼ様酵素 Cut190 による微粉化 PET 分解
Degradation of homogenized PET with cutinase-like enzyme Cut190 form Saccharomonospora
viridis AHK190
Fumiya Kondo1, Miho Emori2, Masayuki Oda1,2 (1Faculty Life. Environ. Sci., Kyoto Pref. Univ., 2Grad.
Sch. Life. Environ. Sci., Kyoto Pref. Univ.)
不凍タンパク質と粘性物質を組み合わせた培養細胞の新規凍結保護剤
Novel cryoprotectants consist of antifreeze protein and viscous additive for cryopreservation ofcultured cells
Luyan Zhang1,2, Akari Yamauchi6, Sakae Tsuda3,4,5, Yasushi Ohyama2, Hidemasa Kondo1,2 (1Graduate
School of Life Science, Hokkaido University, 2Bioproduction Research Institute, National Institute ofAdvanced Industrial Science and Technology (AIST), 3Graduate School of Frontier Sciences, The
University of Tokyo, 4OPERANDO Open Innovation Laboratory, National Institute of Advanced
Industrial Science and Technology (AIST), 5Faculty of Advanced Life Science, Hokkaido University,
6Hibernation Metabolism, Physiology and Development Group, Institute of Low Temperature Science,
Hokkaido University)
オオクワガタ由来不凍タンパク質の特性評価
Characteri zation of antifreeze protein from a stag beetle Dorcus hopei binodulosus
Yuki Iida1,2, Tatsuya Arai3, Akari Yamauchi6, Sakae Tsuda3,4,5, Yasushi Ohyama2, Hidemasa Kondo1,2(1Graduate School of Life Science, Hokkaido University, 2Bioproduction Research Institute, National
Institute of Advanced Industrial Science and Technology, 3Graduate School of Frontier Sciences, The
University of Tokyo, 4OPERANDO Open Innovation Laboratory, National Institute of Advanced
Industrial Science and Technology, 5Faculty of Advanced Life Science, Hokkaido University,
6Hibernation Metabolism, Physiology and Development Group, Institute of Low Temperature Science,
Hokkaido University)
氷結晶結合蛋白質の非凍結細胞保護機能の分子メカニズム解明
Elucidating the molecular mechanism of cell protective function of ice-binding proteins at nonfreezing temperature
Tatsuya Arai1,2, Yue Yang1, Sakae Tsuda1, Kazuhiro Mio2, C. Yuji Sasaki1,2 (1Grad. Sch. Fontier Sci.,
Univ. Tokyo, 2AIST-UTokyo OPERANDO-OIL)– S141 –2Pos069*

2Pos070

2Pos071

2Pos072*

2Pos073

アミロイド β と細胞骨格蛋白質のアクチンおよびチューブリンの間の相互作用は、それらの重合状態に依存する
The interaction between amyloid β and cytoskeletal proteins, actin and tubulin, depends ontheir polymerization state
Yukina Kurotaki1, Ragheed H. Yousif2, Masahiro Kuragano1, Kiyotaka Tokuraku1 (1Muroran Instituteof Technology, 2Al-Farahidi University)
ヒト血清のアミロイド β 凝集阻害活性の評価
Evaluation of Amyloid β aggregation inhibitory activity of human serum
Yuku Yamada, Keiya Shimamori, Tomohiko Katakawa, Masahiro Kuragano, Kiyotaka Tokuraku (Grad.
Sch. Eng. , Muroran Inst. of Tech.)
セリンプロテアーゼ Neuropsin の基質特異性の決定因子に関する MD 研究
MD simulation study on determinant factors for substrate specificity of serine proteaseneuropsin
Masami Lintuluoto1, Yota Horioka1, Mitsumasa Abe1, Yoshifumi Fukunishi2, Juha Mikael Lintuluoto3,
Hideki Tamura4 (1Grad. Sch. Life and Env. Sci., Kyoto Pref. Univ., 2AIST, CMB, 3Grad. Sch. Eng. Kyoto
Univ., 4Hoshi Univ. Sch. Pharm. and Pharm. Sci.)
改良型 Raichu を用いた静水圧印加時の Ras 活性測定
Ras activity measurement under hydrostatic pressure using improved Raichu
Teruhiko Matsuda1, Minki Chang2, Katsuko Furukawa2, Takashi Ushida3, Taro QP Uyeda1 (1Dept. Pure
& Appl. Physics, Grad. Sch. Adv. Sci. & Eng., Waseda Univ./ Japanese, 2Dept. Bio Eng., Fac. Eng., Univ.
Tokyo/ Japanese, 3Dept. Mech. Eng., Fac. Eng., Univ. Tokyo/ Japanese)
EcoRV による DNA 加水分解におけるプロトン移動の量子化学計算による観察
Proton-transfer in hydrolysis of DNA by EcoRV calculated by quantum-chemical metadynamics
Mika Mitsumatsu1, Itaru Onishi1, Norio Yoshida2, Fumio Hirata3, Masayuki Irisa1 (1Kyushu Inst. of
Tech., 2Nagoya Univ., 3IMS)

蛋白質：計測・解析の方法論／Protein: Measurement & Analysis
2Pos074*

2Pos075*

2Pos076

Molecular structure dynamics identification method development based on High speed AFM
imaging data
Yui Kanaoka1, Yuto Nonaka1, Norie Hamaguchi2, Takeshi Murata2, Florence Tama1,3,
Takayuki Uchihashi1 (1Grad. Sch. Sci., Univ. Nagoya, 2Grad. Sch. Sci., Univ. Chiba, 3R-CSS)
ブリルアン・ラマン同時イメージングによる液-液相分離によるタンパク質液滴の変化の観測
Observation of the change in physical condition of a liquid droplet formed by liquid-liquid phaseseparation using Brillouin-Raman imaging
Daiki Shibata1, Shinji Kajimoto1,2, Takakazu Nakabayashi1 (1Grad. Sch. Sci., Tohoku Univ., 2JST
PRESTO)タンパク質モーフィング手法と半自動簡略化経路探索法の膜タンパク質二量体のダイナミクス
への適用
Application of the Protein Morphing Method and the Semi-automatic Simplified Path Exploration
to the Membrane Protein Dimers Dynamics
Ryota Kiyooka1, Masaki Otawa2, Lisa Matsukura1, Naoyuki Miyashita1 (1Grad. Sch. BOST, KINDAI
Univ., 2Grad. Sch. Phys. Sci., GUAS)– S142 –2Pos077*

2Pos078

2Pos079

2Pos080*

2Pos0812Pos082*

2Pos083

2Pos084

2Pos085*

蛍光寿命を用いた LLPS によって生じた FUSLC 液滴の時間変化ダイナミクスの定量解析
Quantitative analysis of time-dependent dynamics of FUS LC droplets formed by LLPS using
fluorescence lifetime
Kaichi Nagai1, Shinya Tahara2, Uchuu Matusura2, Mizuki Sugimoto3, Eita Sasaki4, Shinji Kajimoto2,5,
Kenjiro Hanaoka4, Takakazu Nakabayashi2 (1Faculty of Pharmaceutical Sciences, Tohoku University,
2Graduate school of Pharmaceutical Sciences, Tohoku University, 3Faculty of Pharmacy, Keio
University, 4Graduate School of Pharmaceutical Sciences, Keio University, 5JST PRESTO)
スプリット Akaluc を用いた個体深部における GPCR/β-アレスチン相互作用と細胞融合の検出法
Split Akaluc reconstitution methods for detecting GPCR/β-arrestin interaction and cell fusion
event in deep tissues
Yiling Li, Genki Kawamura, Qiaojing Li, Takeaki Ozawa (Department of Chemistry, School of Science,
The University of Tokyo)
X 線 1 分子追跡法によるイベルメクチン存在下での nAChR α7 の逆回転運動の測定
The Opposite Twisting Motions of Ivermectin-nAChR α7 Monitored by Diffracted X-ray Tracking
Yue Yang1, Tatsuya Arai1,2, Daisuke Sasaki1, Masahiro Kuramochi1,3, Hiroshi Sekiguchi4,
Kazuhiro Mio2, Tai Kubo5, Yuji C. Sasaki1,2,4 (1Grad Sch. of Fron. Sci., Univ. Tokyo, 2AIST-UTokyo,
3Grad Sch. of Sci. and Eng., Univ. Ibaraki, 4JASRI/ SPring-8, 5GlyTech Inc.)
凝集体形成機構解明に向けた電場存在下におけるタンパク質の動的構造解析基盤の確立
Development of a platform for dynamic structural analysis of proteins in electric fields toelucidate the mechanism of aggregate formation
Yusuke Shuto1, Erik Walinda3, Daichi Morimoto2, Kenji Sugase1 (1Grad. Agr., Univ. Kyoto, 2Grad. Eng.,
Univ. Kyoto, 3Grad. Med., Univ. Kyoto)
糊化デンプンを使用したマイクロプレートへの MBP 融合タンパク質固定化法の開発及びタンパ
ク質間相互作用解析への応用
An immobilization method of MBP-fusion proteins using a gelatinized starch-agarose mixture
and its application for PPI analysis
Ryoya Katayama1, Yuri Emoto2, Reiji Hijikata3, Emi Hibino2, Natsuko Goda2, Takeshi Tenno2,
Hidekazu Hiroaki2, Akihiro Narita1 (1Graduate School of Science, Nagoya University, 2Graduated
School of Pharmaceutical Sciences, Nagoya University, 3School of Science, Nagoya University)
インタクトなミトコンドリアにおける電子伝達複合体活性計測
Measurements of electron transfer complex activities in intact mitochondria
Saki Koyama, Momoka Kutami, Yoshiki Suganuma, Hiroko Kashiwagi, Yoshihiro Ohta (Department of
Biotechnology and Life Sciences, Graduate school of Engineering, Tokyo University of Agriculture andTechnology)
ペプチドの伸長に伴うエネルギー準位統計の分化と分子進化
Evolution of Energy Level Statistics and Molecular Evolution with Peptide Elongation
Masanori Yamanaka (CST, Nihon Univ.)
ポリアミノ酸検出のためのナノポア阻害電流解析法の開発
Developing Current Analyses for Nanopore Detection of Poly(amino acid)s
Misa Yamaji, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology)
生体用ナノポア用いた α-helix 及び β-hairpin ペプチドのアンフォールディング挙動観察
Observation of unfolding behavior of peptides with a-helix and b-hairpin through a biological
nanopore
Miyu Fukuda, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology.)– S143 –蛋白質：蛋白質工学／進化工学／Protein: Engineering
2Pos086*

2Pos087*

2Pos088

2Pos089*

2Pos090*

2Pos091*

2Pos092

2Pos093*

合理的設計手法による SARS-CoV-2 変異体に対する中和抗体の開発
Development of neutralizing antibodies against SARS-CoV-2 variants by rational design
Rina Aoyama1, Sairi Matsumoto1, Nao Sato1, Shunji Suetaka1, Yuuki Hayashi1,2, Munehito Arai1,3(1Dept. Life Sci., Univ. Tokyo, 2Environmental Sci. Ctr., Univ. Tokyo, 3Dept. Phys., Univ. Tokyo)
Reverse Engineering Analysis of the High-Temperature Reversible Oligomerization andAmyloidogenicity of PSD95-PDZ3
Sawaros Onchaiya1, Tomonori Saotome2, Kenji Mizutani3, Jose C. Martinez4, Jeremy R. H. Tame3,
Shun-ichi Kidokoro2, Yutaka Kuroda1 (1Department of Biotechnology and Life Science, Tokyo Universityof Agriculture and Technology, 2-24-16, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan, 2Department of
Bioengineering, Nagaoka University of Technology, 1603-1, Kamitomioka-cho, Nagaoka-shi 940-2188,
Niigata, Japan, 3Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro,
Yokohama 230-0045, Kanagawa, Japan, 4Department of Physical Chemistry, Institute of Biotechnology,
Faculty of Sciences, University of Granada, 18071 Granada, Spain)
アレルギー疾患を阻害しうるタンパク質の合理的設計
Rational design of proteins that can inhibit allergic diseases
Mizuki Teranishi1, Nao Sato1, Shunji Suetaka1, Mio Sano1, Yuuki Hayashi1,2, Munehito Arai1,3 (1Dept.
Life Sci., Univ. Tokyo, 2Environment Science Center, Univ. Tokyo, 3Dept. Phys., Univ. Tokyo)
タンパク質間相互作用を阻害するヘリックス模倣化合物の探索
Search for helix-mimetic compounds that inhibit protein-protein interactions
Nao Sato1, Shunji Suetaka1, Eiji Honda2, Hajime Takashima2, Dai Takehara2, Atsushi Yoshimori3,
Yuuki Hayashi1,4, Munehito Arai1,5 (1Department of Life Sciences, The University of Tokyo., 2PRISM
BioLab Co., Ltd., 3Institute for Theoretical Medicine, Inc., 4Environmental Science Center, The
University of Tokyo., 5Department of Physics, The University of Tokyo.)
Pichia pastoris を用いた組換えタンパク質発現系におけるシステインに富んだタンパク質の折り
たたみと収量に関わる因子の解明
Factors involved in the folding and yield of cysteine-rich proteins in recombinant expression
system using Pichia pastoris.
Ami Hanaoka1, Tomona Iizuka1, Jingkang Zheng1, Ichiho Yoshikawa2, Wenqing Cai1, Yurie Nakajima1,
Soma Ishihara2, Tomoyasu Aizawa1,2 (1Grad. Sch. Life Sci., Hokkaido Univ., 2Sch. Sci., Hokkaido Univ.)
細胞内光遺伝学ツール Magnets 変異体の比較とさらなる改良
Comparison and further improvement of the intracellular optogenetic tool Magnets variants
Masataka Yoshimura1, Yuki Aono1, Yuuki Hayashi1,2, Fuun Kawano1, Moritoshi Sato1,
Munehito Arai1,3 (1Dept. Life Sci., Univ. Tokyo, 2Env. Sci. Ctr., Univ. Tokyo, 3Dept. Phys., Univ. Tokyo)
ピキア酵母を用いたシステインリッチアレルゲン蛋白質の過剰発現系における非天然型ジスル
フィド結合と修飾の検討
Investigation of non-native disulfide bonds and modification in the overexpression of cysteinerich allergens by Pichia pastoris
Ichiho Yoshikawa1, Ami Hanaoka2, Tomona Iizuka2, Jingkang Zheng2, Wenqing Cai2, Soma Ishihara1,
Yurie Nakajima2, Tomoyasu Aizawa1,2 (1Sch. Sci., Hokkaido Univ., 2Grad. Sch. Life Sci., Hokkaido Univ.)
LL-37 型 cathelicidin ファミリー抗菌ペプチドの組換え発現と NMR 解析による免疫進化研究
Immunological evolution studies combining NMR and recombinant overexpression of the LL-37like cathelicidin family antimicrobial peptides
Mitsuki Shibagaki1, Waka Ueda1, Kohei Kano1, Hao Gu1, Tomoyasu Aizawa1,2 (1Grad. Sch. Life Sci.,
Hokkaido Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)– S144 –2Pos094*

相分離タンパク質の天然変性領域の配列に基づく、相分離ペプチドの合理的設計
Rational design of phase-separating peptides based on natural phase-separating protein
disordered sequence
Atsumi Hando1,2, Maulana Ariefai1,3, Nanako Iwaki1,4, Saori Kanbayashi1, Keisuke Ikeda5,
Kiyoto Kamagata1,2,3,4 (1IMRAM, Tohoku Univ., 2Grad. Sch. Life Sci., Tohoku Univ., 3Dep. Chem., Fac.
Sci., Tohoku Univ., 4Dep. Chem., Grad. Sch. Sci., Tohoku Univ., 5Fac. Pharm. Sci., Univ. Toyama)

ヘム蛋白質／Heme proteins
2Pos095*

2Pos096

2Pos097

2Pos098

シトクロム P450BM3 の非天然反応を誘起するペプチド性小分子の開発およびその作用の解明
Evolution of Dipeptidic Molecules for the Induction of the Non-native Catalysis of Cytochrome
P450BM3 and the Analysis of the Mechanisms
Kai Yonemura1, Shinya Ariyasu1, Hiroshi Sugimoto2, Shigeru Matsuoka3, Osami Shoji1 (1Graduate
School of Science, Nagoya University, 2RIKEN/SPring-8, 3Faculty of Medicine, Oita University)
Direct Visualization of Hydrogen Atoms in the Haem-Acquisition Protein HasA Capturinga Synthetic Metal Complex by Protein Crystallography
Yuma Shisaka1, Hiroshi Sugimoto2, Naomine Yano3, Katsuhiro Kusaka3, Masaki Unno3,4, Osami Shoji5(1RIKEN Center for Sustainable Resource Science, 2RIKEN SPring-8 Center, 3Frontier Research Center
for Applied Atomic Sciences, Ibaraki University, 4Graduate School of Science and Engineering, Ibaraki
University, 5Graduate School of Science, Nagoya University)
インドールアミン 2,3-ジオキシゲナーゼの電気化学的なレドックス制御と迅速な阻害アッセイ
Redox control of human indoleamine 2,3-dioxygenase at nanostructured electrode surface andits inhibitor screening
Yasuhiro Mie1, Chitose Mikami1, Yoshiaki Yasutake1,2, Yuki Shigemura3, Hirofumi Tsujino3,4,
Taku Yamashita5 (1Bioproduction Res. Inst., AIST, 2CBBD-OIL, AIST-Waseda Univ., 3Grad. Sch. Pharm.
Sci., Osaka Univ., 4Museum, Osaka Univ., 5Sch. Pharm., Mukogawa Women’s Univ.)
ミオグロビンへの協同的な配位子結合性付与に向けた二量体の合理的設計
Rational design of myoglobin dimers for ligand binding cooperativity
Satoshi Nagao1, Chihiro Maruo2, Masashi Yamada2, Daichi Yamada1, Minoru Kubo1 (1Grad. Sch. Sci.,
Univ. Hyogo, 2Sch. Sci., Univ. Hyogo)

膜蛋白質／Membrane proteins
2Pos099

2Pos100

2Pos101

シュウ酸トランスポーター OxlT の未解明構造の分子動力学的探索
Molecular dynamics search for the unknown structural state of oxalate transporter OxlTJun Ohnuki, Kei-ichi Okazaki (Institute for Molecular Science)
ヒト L 型アミノ酸トランスポーター LAT1-CD98hc 複合体の基質輸送シミュレーション
Substrate transport simulations of human L-type amino acid transporter LAT1-CD98hc complex
coupled with conformational changes
Natsumi Yoshida1, Toru Ekimoto1, Tsutomu Yamane2, Mitsunori Ikeguchi1,2 (1Grad. Sch. Med. Life Sci.,
Yokohama City Univ., 2RIKEN R-CCS)
病原菌ヘム ABC トランスポーターのクライオ電子顕微鏡解析
Cryo-EM analysis of bacterial heme ABC transporter
Machika Kataoka1,2, Ayaho Abe1,2, Gopalashingam Chai2, Gerle Christoph2, Yoshitsugu Shiro1,
Masaki Yamamoto2, Hideki Shigematsu3, Hiroshi Sugimoto1,2 (1Grad. Sch. Sci., Univ. Hyogo, 2RIKEN
SPring-8 Center, 3JASRI)– S145 –2Pos102

2Pos103*

2Pos104

2Pos105

2Pos106*

高速 AFM による ABC トランスポーター P-gp の動態観察
HS-AFM Observation of Conformational Dynamics of ABC transporter P-gp
Yuto Nonaka1, Norie Hamaguchi2, Fumi Nakagawa2, Satoru Ogasawara2, Takesi Murata2,
Takayuki Uchihashi1 (1Grad. Sch. Phys., Univ. Nagoya / Japanese, 2Grad. Sch. sci., Univ. Chiba. /Japanese)
局所熱パルス法を用いた 1 型リアノジン受容体の中間領域変異体の高熱感受性解析
Malignant hyperthermia-implicated heat hypersensitive mutations in the central region of RyR1
channel studied by a local heat pulse method
Chujie Liu1,2, Takashi Murayama3, Toshiko Yamazawa4, Kotaro Oyama5, Yoshie Harada2,6,
Madoka Suzuki2 (1Department of Biological Sciences, Graduate School of Science, Osaka University,
2Institute for Protein Research, Osaka University, 3Department of Cellular and Molecular
Pharmacology, Juntendo University Graduate School of Medicine, 4The Jikei University School of
Medicine, 5National Institutes for Quantum Science and Technology, 6Center for Quantum Information
and Quantum Biology, Osaka University)
ナノディスクに挿入したカリウムチャネル KcsA の構造
KcsA K+ Channel Structure Incorporated into Nanodisc
Hiroko Takazaki1, Hirofumi Shimizu2, Takuo Yasunaga3 (1IPR, Univ. Osaka, 2Fac. Med. Sci., Univ.
Fukui, 3Grad. Sch. Comp. Sci. Syst. Eng., KIT)
X 線 1 分子追跡法を用いた TRPV1 チャネルの細胞内ドメイン動態計測
Intramolecular dynamics of TRPV1 channel using Diffracted X-ray Tracking
Tatsunari Ohkubo1,2, Shoko Fujimura2,3, Kazuhiro Mio1,2, Hiroshi Sekiguchi4, Yuji C. Sasaki2,3,4(1Grad. Sch. Med. Sci., Yokohama CU, 2Operand OIL, AIST, 3Grad. Sch. of Front. Sci., The Univ ofTokyo, 4JASRI)
EXP2 ナノポアとその変異体を用いたペプチドの 1 分子検出
Single-molecule detection of peptides using EXP2 nanopore and its variant
Mitsuki Miyagi, Sotaro Takiguchi, Kazuaki Hakamada, Masafumi Yohda, Ryuji Kawano (Department of
Biotechnology and Life Science, Tokyo University of Agriculture and Technology)

核酸結合蛋白質／Nucleic acid binding proteins2Pos107

2Pos108
2Pos109*

2Pos110

DNA 液滴内での DNA 結合タンパク質の標的 DNA 探索の単分子観察
Single-molecule characterization of target search of DNA-binding proteins inside liquid DNA
droplets
Ryo Kusano1,2, Trishit Banerjee1,2, Saori Kambayashi1, Kiyoto Kamagata1 (1IMRAM, Tohoku Univ.,
2Department of Chemistry, Tohoku Univ.)
Molecular dynamics study of the three prime repair exonuclease 1 and its mutants
Hiroki Otaki (Grad. Sch. of Biomedical Sci., Nagasaki Univ.)(2SEP-3) RNase T2 のリボソームへの結合を介した翻訳阻害機構(2SEP-3) Regulation mechanism of translation through the interaction of RNase T2 withribosome
Atsushi Minami1, Takehito Tanzawa2, Zhuohao Yang3, Takashi Funatsu3, Takayuki Kato2,
Tomohisa Kuzuyama1,4, Hideji Yoshida5, Tetsuhiro Ogawa1,4 (1Grad. Sch. Agri. and Life Sci., Univ.
Tokyo, 2IPR, Osaka Univ., 3Grad. Sch. Pharm. Sci., Univ. Tokyo, 4CRIIM, Univ. Tokyo, 5Fac. Med., OsakaMed. Pharm. Univ.)
ヌクレオリン核酸結合ドメインと 4 重鎖 DNA との結合過程
The binding process of quadruplex DNA to RNA/DNA binding domains of nucleolin
Masato Morikawa1, Kota Yamaguchi1, Kazuki Kawada2, Koji Umezawa1,2,3 (1Grad. Sch. of Sci. &Tech., Shinshu Univ., 2Dept. Agri., Shinshu Univ., 3IBS., Shinshu Univ.)– S146 –核酸：構造・物性／Nucleic acid: Structure & Property
2Pos1112Pos1122Pos113*

2Pos1142Pos115
2Pos116*

2Pos117微小閉鎖空間がポリヌクレオソーム凝縮に与える影響の検討
Investigation of the effect of spherical (three-dimensional) confinement on the higher order
structure of 12-mer nucleosome arrays
Masahiro Okabe (Dept. Biol. Sci., Grad. Sch. Sci., The Univ. Tokyo)
一本鎖 DNA は核小体周囲に凝集体を形成する
Single-stranded DNA forms condensates surrounding nucleoli
Koichiro Maki1,2, Jumpei Fukute1,3, Taiji Adachi1,2,3 (1Inst. Life Med. Sci., Kyoto University, 2Grad. Sch.
Eng., Kyoto University, 3Grad. Sch. Biostudies, Kyoto University)
ヒト生細胞内環境における三重鎖 DNA 分子の構造及びダイナミクスの解析
Analysis of the structure and dynamics of triplex forming oligodeoxynucleotide in living humancells
Tomoki Sakamoto1,2, Yudai Yamaoki1,2, Takashi Nagata1,2, Masato Katahira1,2 (1Inst. Adv. Energy, Kyoto
Univ., 2Grad. Sch. Energy Sci., Kyoto Univ.)
動的ループによる染色体コンパートメントの形成と変化
Dynamic loops shape and reshape chromosome compartments
Shin Fujishiro1,2, Masaki Sasai1,2 (1Fukui Inst. Fund. Chem., Kyoto Univ., 2Dept. Complex Sys. Sci.,
Nagoya Univ.)
FRET study of the sequence dependence of nucleosomal DNA unwrapping
Tomoko Sunami, Hidetoshi Kono (QST, iQLS)(2SBA-4) 細胞核内における underwound DNA の蛍光イメージング(2SBA-4) Fluorescence imaging of underwound DNA in the cell nucleus
Jumpei Fukute1,2, Koichiro Maki1,3, Taiji Adachi1,2,3 (1Inst. Life & Med. Sci., Kyoto Univ., 2Grad. Sch.
Biostudies, Kyoto Univ., 3Grad. Sch. Eng., Kyoto Univ.)
ラマン顕微鏡を用いた生細胞内のクロモセンターのラベルフリー成分・構造解析
Label-free compositional and structural analysis of chromocenters in living cells using Raman
microscopy
Masato Machida1, Atsushi Shibata2, Kentaro Hujii3, Shinji Kajimoto1,4, Takakazu Nakabayashi1 (1Grad.
Sch. Pharm. Sci., Univ. Tohoku, 2GIAR., Univ. Gunma, 3QST., 4JST PRESTO.)

核酸：相互作用・複合体／Nucleic acid: Interaction & Complex formation
2Pos118*

2Pos119*

2Pos120*

高速原子間力顕微鏡による H2A.Z.1 ヌクレオソームの DNA 上での自発的スライディングの直接観察
Direct imaging of spontaneous sliding along DNA of H2A.Z.1 nucleosome by high-speed
atomic force microscopy
Shin Morioka1, Shoko Sato2, Naoki Horikoshi2, Tomoya Kujirai2, Hitoshi Kurumizaka2,
Mikihiro Shibata3,4 (1Grad. Sch. Math. & Phys., Kanazawa Univ., 2Institute of Quantitative Biosciences,
Tokyo Univ., 3WPI-NanoLSI, Kanazawa Univ.,, 4InFiniti, Kanazawa Univ.)
DNA ハイブリダイゼーションのカイネティックなエラー抑制
Kinetic error suppression of DNA hybridization
Hiroyuki Aoyanagi1, Simone Pigolotti2, Shinji Ono1, Shoichi Toyabe1 (1Grad. Sch. Eng., Tohoku Univ,
2OIST)(1SGA-2) 人工核酸 PNA を用いた DNA の液－液相分離制御(1SGA-2) Regulation of liquid-liquid phase separation of DNA using peptide nucleic acid (PNA)
Rikuto Soma, Yuichiro Aiba, Masanari Shibata, Shinya Ariyasu, Osami Shoji (Graduate School of
Science, Nagoya University.)– S147 –2Pos121*

2Pos122*

非平衡ダイナミクスを示す酵素反応によって活性化された DNA 液滴
Enzymatically activated DNA-droplets exhibiting non-equilibrium dynamics
Tomoya Maruyama1, Masahiro Takinoue1,2 (1School of Life science and Technology, Tokyo Institute ofTechnology, 2School of Computer Science, Tokyo Institute of Technology)
再構成転写翻訳系におけるトランスファー RNA の合成と共役した翻訳および DNA 複製システム
Transfer RNA synthesis-coupled translation and DNA replication in a reconstituted
transcription/translation system
Ryota Miyachi1, Yoshihiro Shimizu2, Norikazu Ichihashi1,3,4 (1Grad. Sch. Arts Sci., Univ. Tokyo, 2Center
for Biosystems Dynamics Research, Riken, 3Komaba Institute for Science, Univ. Tokyo, 4Research Centerfor Complex Systems Biology, Universal Biology Institute, Univ. Tokyo)

水・水和／電解質／Water & Hydration & Electrolyte
2Pos123

2Pos124*
2Pos125

2Pos126

2Pos127*

2Pos128

MD シミュレーションによるタンパク質モデルペプチド周囲の水和ダイナミクスの解明
MD simulations reveals hydration dynamics around protein model peptides
Takuya Takahashi1, Ryutaro Inou2, Yui Nakamura2 (1Coll. Life Sci., Ritsumeikan Univ., 2Grad. Sch. Life
Sci., Ritsumeikan Univ.)
Effect of local electric field on the rotational dynamics of water dipole in protein solutions
Kang Hu1,2, Ryo Shirakashi1 (1IIS, Univ. Tokyo, 2Grad. Sch. Eng., Univ. Tokyo)
ニューラルネットワークと経験分布の融合的手法による膜蛋白質の水和構造予測
Prediction of hydration structures of membrane proteins using neural networks in combination
with the empirical hydration distribution
Kochi Sato1,2, Mao Oide1,2, Masayoshi Nakasako1,2 (1Dept. Phys., Keio Univ., 2RSC, RIKEN)Free energy analysis of the addition of small molecules with simple structures to elucidate cosolvent effects in insulin dissociation
Simon Hikiri, Nobuyuki Matubayasi (Grad. Sch. Eng. Sci., Osaka Univ.)
酸性タンパク質凝集解明のための分子シミュレーションによる電解質溶液中のアニオン間実効引力の研究
Molecular simulation study of effective attraction between anions in an electrolyte solution forelucidation of acidic protein aggregation
Michika Takeda1, Ryo Akiyama2 (1Grad. Sch. Sci. Kyushu Univ., 2Inst. Sci. Kyushu Univ.)
水と生体分子のシミュレーションにおける静電相互作用計算：オンサーガモデルによる理論的検証
Theoretical study on the electrostatic calculation in biomolecular simulation
Yoshiteru Yonetani (QST)

発生・分化／Development & Differentiation
2Pos129*

2Pos130

幹細胞分化のモデル系を模した人工遺伝子回路の生じる空間パターン
Spatial patterns formed by a synthetic genetic circuit mimicking the model of stem celldifferentiation
Kei Ikemori, Yuichi Wakamoto (Grad. Sch. of Art. & Sci., Univ. Tokyo)
Planar cell polarity–dependent asymmetric organization of microtubules for polarized
positioning of the basal body in node cells
Xiao Rei Sai1, Kastura Minegishi2, Hiroshi Hamada1 (1Riken BDR, 2National Center of Neurology andPsychiatry)– S148 –2Pos131

2Pos132*

マウスノード不動繊毛は変形の向きを感知して左右軸を決定する: 非対称性を生み出すメカニカ
ルな機構
Mouse nodal immotile cilia sense bending direction for left-right determination: Mechanicalregulation in initiation of symmetry breaking
Takanobu A Katoh1, Toshihiro Omori2, Katsutoshi Mizuno3, Takeshi Itabashi1, Atsuko H. Iwane1,
Takuji Ishikawa2, Yasushi Okada1,4, Takayuki Nishizaka5, Hiroshi Hamada1 (1BDR, Riken, 2Grad. Sch.
Eng., Tohoku Univ., 3Fac. Med. Sci., Univ. of Fukui, 4Grad. Sch. Med., Grad. Sch. Sci., UBI, WPI-IRCN,The Univ. of Tokyo, 5Fac. Sci., Gakushuin Univ.)
物理的環境の非対称性が上皮折り畳みパターン選択に果たす役割
Role of asymmetry of physical environment in epithelial folding pattern selection
Kentaro Morikawa, Daich Kuroda, Yasuhiro Inoue (Grad. Sch. Eng., Kyoto Univ.)

筋肉（筋蛋白質・収縮）／Muscle
2Pos133

2Pos134

2Pos135

2Pos136

2Pos137

微小管脱重合薬により骨格筋の粘弾性は変化する
The viscoelasticity of skeletal muscle is altered by microtubule destabilized agent
Takuya Kobayashi, Takashi Murayama, Nagomi Kurebayashi (Dept. of Cellular and Molecular
Pharmacology, Juntendo University)
細菌アクチン MreB の繊維構造多型
Filament structural polymorphism of bacterial actin MreB
Daichi Takahashi1, Ikuko Fujiwara1,2,3, Akihiro Narita4, Makoto Miyata1,2 (1Grad. Sch. Sci., Osaka
Metropolitan Univ., 2OCARINA, Osaka Metropolitan Univ., 3Dept. Mater. Sci. Bioeng., Nagaoka Univ.
Tech., 4Grad. Sch. Sci., Nagoya Univ.)
Absolute Reward in Large Feature Space: Tracking by Linear Bandit
Md Menhazul Abedin1,2, Koji Tabata3,4, Tamiki Komatsuzaki1,3,4 (1Graduate School of Chemical
Sciences and Engineering, Hokkaido University, Japan, 2Khulna University, Bangladesh, 3Institute for
Chemical Reaction Design and Discovery (ICReDD), Hokkaido University, Japan, 4Research Institute forElectronic Science, Hokkaido University, Japan)
アクトミオシンの弱結合－強結合転移におけるクーロン駆動機構
Coulombic drive for the weak-to-strong binding transition in actomyosin
Kyohei Shoji, Mitsunori Takano (Dept. of Pure & Appl. Phys., Grad. Scl. Adv. Sci. & Eng., Waseda
Univ.)
自由エネルギーランドスケープの切り替えとパワーストロークを考慮した筋収縮の 6 状態モデ
ルの構築
Construction of six-state model of muscle contraction with switched free energy landscape andpower stroke
Shunta Oda, Tomoki P. Terada (Dept. Appl. Phys., Grad. Sch. Eng., Nagoya Univ.)

分子モーター／Molecular motor
2Pos138

2Pos139*

FoF1-ATPase の非触媒部位の機能解明
Functional elucidation of the non-catalytic site of FoF1-ATPase
Ren Kobayashi, Atsuki Nakano, Ken Yokoyama (Department of Molecular Biosciences,Kyoto Sangyo)
無細胞タンパク質合成と 1 分子回転観察を組み合わせた F1-ATPase の in vitro スクリーニング
In vitro screening of F1-ATPase based on single molecule rotation assay coupled to cell-freeprotein synthesis
Mai Taguchi, Hiroshi Ueno, Hiroyuki Noji (Grad. Sch. Eng., Univ. Tokyo)– S149 –2Pos140

2Pos141*2Pos1422Pos143

2Pos144

2Pos145*

2Pos146

2Pos147

2Pos148*2Pos149

H+輸送律速における変異型 FoF1-ATPase の回転
ATP driven rotation of mutant FoF1 where H+ translocation is rate-limiting
Kiyoto Yasuda1, Daichi Ando1, Ryohei Kobayashi1,2, Hiroshi Ueno1, Hiroyuki Noji1 (1Appl. Chem.,
Grad. Sch. Eng., Univ. Tokyo, 2Inst. for Mol. Sci.)
Vo 部分での回転によるプロトン輸送機構の分子基盤
Structural basis on the rotary mechanism of Vo domain by proton translocation
Yui Nishida1, Junichi Kishikawa2, Atsuko Nakanishi3, Atsuki Nakano4, Ken Yokoyama1,4 (1Dept. of
Bioscience., Kyoto Sangyo Univ., 2IPR, Osaka Univ., 3Research Center for UHVEM., 4Grad. Sch.
Bioscience., Kyoto Sangyo Univ.)
分子動力学計算による F1-ATPase のリン酸放出経路の探索
Exploration of phosphate release pathway of F1-ATPase with molecular dynamics calculation
Masahiro Motohashi1, Mao Oide2, Eiro Muneyuki1, Yuji Sugita2 (1Grad. Sch. Sci. Eng., Univ. Chuo,
2Wako Inst., Riken)
Single molecule observation of kinesin-1 on collectively aligned microtubules
Tomoka Kashiwabara1, Syeda Rubaiya Nasrin2, Arif Md. Rashedul Kabir2, Akira Kakugo2,
Yusuke T. Maeda1 (1Fac. Sci. Grad. Sch. Sci., Univ. Kyushu, 2Fac. Science, Hokkaido University)
Hybrid kinesin-1 dimer conjugated with synthetic PEG linker shows processive and fast motion
with robust hand-over-hand mechanism
Jakia Jannat Keya1, Akasit Visootsat1, Kimitoshi Takeda1, Akihiro Otomo1, Wijak Yospanya2,
Sanghun Han2, Kazushi Kinbara2, Ryota Iino1 (1Institute for Molecular Science, National Institutes of
Natural Sciences, 2School of Life Science and Technology, Tokyo Institute of Technology)
The movement of kinesin with the neck linker hanging free in solution
Rieko Sumiyoshi, Masahiko Yamagishi, Mitsuhiro Sugawa, Junichiro Yajima (Grad. Arts & Sci., Univ.
Tokyo)
架橋微小管-キネシンの in vitro 運動系でマクロに出力する微小管群の観察
Observation of cross-linked microtubules transmitting integrated forces of multiple kinesin
motors in vitro
Ryuzo Kawamura1, Naruaki Tsuji1, Naritaka Kobayashi2, Takahisa Matsuzaki1,3,
Hiroshi Y. Yoshikawa1,3 (1Grad. Sch. Sci. Eng., Saitama Univ., 2Sch. Eng., Univ. of Shiga Pref., 3Grad.
Sch. Eng., Osaka Univ.)
タンパク質の 2D 投影像の深層学習によるミオシンの構造分類法の研究
Structure classification of myosin by deep learning of 2D projection images
Hitomi Wada1, Hiroko Takazaki2, Takuo Yasunaga1 (1Grad. Sch. Comp. Sci. Syst. Eng., KIT., 2IPR,
Univ. Osaka)
ミオシン 1c に駆動される F-アクチンのコークスクリュー運動
Corkscrew motion of F-actin driven by myosin-1cYusei Sato1, Kohei Yoshimura2, Kyohei Matsuda1, Akisato Marumo1, Takeshi Haraguchi3,Masahiko Yamagishi1, Mitsuhiro Sugawa1, Kohji Ito2,3, Junichiro Yajima1 (1Dep. of Life Sciences, Grad.
School of Arts and Sciences, The University of Tokyo, 2Dep. of Biology, Chiba Uni., 3Dep. of Biology,
Chiba Uni.)
軸糸ダイニンの協調性は外腕ダイニン中間鎖 2 によって制御される
Cooperative interactions between axonemal dyneins are regulated by the intermediate chain 2of outer-arm dynein
Yusuke Kondo1, Tomoka Ogawa2, Emiri Kanno3, Masafumi Hirono4, Takako Minoura3, Ritsu Kamiya3,
Toshiki Yagi1,2 (1Grad. Sch. comp. Sci., Pref. univ. Hiroshima, 2Fac. Biores. Sci., Pref. univ. Hiroshima,
3Fac. Sci., Chuo. Univ, 4Dept. of Front . Life Sci., Hosei Univ.)– S150 –2Pos150

2Pos151

2Pos152

2Pos153

2Pos154*

細菌べん毛モーター回転子ー固定子間相互作用のアミノ酸レベルでの解析
Analysis of the interaction interface between the rotor and stator of the bacterial flagellar motor
at the amino acid residue level
Jin Nakaya1, Yumi Kumazaki1, Tsubasa Ishida2, Myu Yoshida3, Rie Ito3, Yoshiyuki Sowa1,2,3 (1Grad.
Sch. Sci. & Eng., Hosei Univ., 2Res. Cent. Micro-nano Tech., Hosei Univ., 3Dept. Frontier Biosci., Hosei
Univ.)
真核生物鞭毛・繊毛軸糸構造の X 線回折トモグラフィー：クシクラゲ櫛板の利用
X-ray diffraction-based computed tomography of axonemal structure of eukaryotic flagella/cilia:
Use of Ctenophore comb plates
Hiroyuki Iwamoto1, Kei Jokura2, Kazuhiro Oiwa3, Kazuo Inaba2 (1SPring-8, JASRI, 2Shimoda Marine
Res. Ctr., Univ. Tsukuba, 3Bio-ICT Lab., Nat. Inst. Inf. Com. Tech.)
べん毛 III 型輸送 ATPase 複合体の構造変化と作動機構
Structural change of the ATPase ring complex of the flagellar Type III export apparatus
Asako Usui1, Tatsunari Yano1, Yuki Tajimi2, Norihiro Takekawa1, Miki Kinoshita3, Tohru Minamino3,
Takayuki Uchihashi2, Katsumi Imada1 (1Dept. of Macromol. Sci., Grad. Sch. of Sci., Osaka Univ., 2Dept.
of phys. Sci., Grad. Sch. of Sci., Nagoya Univ., 3Grad. Sch. of Frontier Biosci., Osaka Univ.)
Structural modeling of condensin by assimilating high-speed atomic force microscopy images
Hiroki Koide1, Noriyuki Kodera2, Mayu Terakawa1, Shoji Takada1, Tsuyoshi Terakawa1 (1Grad. Sch.
Sci. Kyoto Univ., 2NanoLSI Kanazawa Univ.)
べん毛 III 型分泌装置の ATPase FliI の HS-AFM 観察
Observation of flagellar type III secretion system ATPase FliI by HS-AFM
Yuki Tajimi1, Asako Usui2, Tatsunari Yano2, Norihiro Takekawa2, Katsumi Imada2,
Takayuki Uchihashi1,3 (1Dept. of phys. Sci., Grad. Sch. of Sci., Nagoya Univ., 2Dept. of Macromol. Sci.,
Grad. Sch. of Sci., Osaka Univ, 3ExCELLS)

細胞生物学的課題（接着，運動，骨格，伝達，膜）／Cell biology
2Pos155*

2Pos156
2Pos157*

2Pos158

2Pos159

蛍光色や偏光方向を選択可能な汎用的分子配向プローブ Nanobody-based POLArIS の開発
Nanobody-based POLArIS: a versatile molecular orientation probe with options of colors andfluorescence polarization orientations
Nori Nakai-Kadowaki1, Keisuke Sato1, Tomomi Tani2, Masahiko Kawagishi1, Hiromasa Ka1,
Kenta Saito1, Sumio Terada1 (1Dept. of Neuroanatomy and Cellular Neurobiology, Grad. Sch. Med. &Dent. Sci., Tokyo Med. & Dent. Univ., 2Biomedical Research Institute, Nat. Inst. Adv. Ind. Sci. & Tech.)
Understanding of robustness in cancer morphology in cold temperature
Yuta Sekiguchi, Hideo Higuchi, Motoshi Kaya (Grad. Sch. Sci., Univ. Tokyo)
酵母胞子の形成・復帰過程における分子混雑の可逆的な制御
Reversible regulation of molecular crowding in fission yeast during sporulation and germination
Keiichiro Sakai1,2,3, Yuhei Goto1,2,3, Yohei Kondo1,2,3, Kazuhiro Aoki1,2,3 (1NIBB, 2ExCELLS,
3SOKENDAI)
光照射による多細胞システムの運動制御
Regulation of cell motility in a multicellular system by photodamage
Shinji Yokoyama (grad. Sch Comp. Sci and Sys .Eng.,Kyushyu Inst. Tech)
深層学習を用いた D. discoideum の 2 細胞型混合集団運動における運動規則の推定
Deep learning-based estimation of motion rules for 2-cell type mixed collective motion of D.
discoideum
Masahito Uwamichi, Hidenori Hashimura, Tomoko Adachi, Sumie Eto, Satoshi Sawai (Grad. Sch. Arts
and Sci., The Univ. of Tokyo)– S151 –2Pos160*

2Pos161

2Pos162*

2Pos163

2Pos164*

2Pos165

2Pos166*

2Pos167

2Pos168

2Pos169

2Pos170

ATP 産生阻害した細胞における細胞内流動性低下の定量的評価
Quantitative evaluation of the decrease in intracellular mobility of cells in which ATP synthesis
is inhibited
Hideaki Ota, Hideo Higuchi (Grad. Sch. Sci., Univ. Tokyo)
プライマリー神経堤細胞の定量的運動解析
Quantitative characterization of random and persistent locomotion in neural crest cell primarycultures
Takehiro Nakamura, Satoshi Sawai (Grad. Sch. Arts & Sci., Univ. Tokyo)
ケラトサイト細胞集団運動におけるアクトミオシンケーブルの切断と集団運動での役割
Breaking of actomyosin cables in keratocyte collectives and their role in the coordinatedcollective migration
Misaki Iwanaga1, Chika Okimura1, Tatsunari Sakurai2, Tasuku Ueno3, Yasuteru Urano3,4,
Yoshiaki Iwadate1 (1Grad. Sch. Sci. Tech., Yamaguchi Univ., 2Dept. Math. Eng., Musashino Univ., 3Grad.
Sch. Pharm. Sci., Univ. Tokyo, 4Grad. Sch. Med. Univ., Tokyo)
真核生物の走化性に焦点を当てた、細胞膜上での Gα2 の PALM イメージングと空間的解析
PALM imaging and spatial analysis of Gα2 across the cell membrane: exploring the meaningin eukaryotic chemotaxis
Atsuhiro Mii1, Satomi Matsuoka1,2,3, Masahiro Ueda1,2,3 (1Grad. Sch. Front. Biosci., Osaka Univ., 2Dept.
Biol. Sci., Grad. Sch. Sci., Osaka Univ., 3BDR, RIKEN)GEFB と GEFX は細胞運動に重要な興奮系 Ras の自発的対称性の破れを制御する
GEFB and GEFX regulate spontaneous symmetry breaking of the excitable system Ras forcell motility
Koji Iwamoto1, Satomi Matsuoka1,2,3, Masahiro Ueda1,2,3 (1Grad. Sch. Sci. Bio, Univ. Osaka, 2Grad.
Sch. of Front. Biosci., Univ. Osaka, 3BDR., Riken)
Loss of synchronous behavior in cardiomyocyte networks is independent of their spatial
network patterns during hERG ion channel blocking
Kazufumi Sakamoto, Kenji Yasuda (Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda
Univ.)
電子線トモグラフィーによる Mycoplasma mobile 内部滑走装置の解析
Mycoplasma mobile internal gliding machinery analyzed by electron tomography
Minoru Fukushima1, Takuma Toyonaga1,2, Yuhei Oba Tahara1, Daisuke Nakane3, Makoto Miyata1,2(1Grad. Sch. Sci., Osaka Metropolitan Univ. Osaka, 2OCARINA, Osaka Metropolitan Univ., 3Grad. Sch.
Info. Eng., Univ. Electro-Communication. Tokyo)
ヒト原腸形成の自己組織化を模倣する：ヒト iPS 細胞のマイクロパターン培養
Mimicking the self-organization of human gastrulation: micro pattern culture of human iPS cells
Chihiro Takeuchi1, Ryo Kobayashi1, Kiyoshi Ohnuma2 (1Grad. Sch. Eng., Univ. Nagaoka Tech., 2Inn.,
Univ. Nagaoka Tech.)
Real-Time Feedback 機構を用いた細胞集合体への機械刺激
Mechanical stimulus on cell aggregation with Real-Time Feedback control
Ayu Sasaki, Ryu Kidokoro, Shota Nozaki, Kaito Kojima, Arata Nagai, Yuuta Moriyama,
Toshiyuki Mitsui (Grad. Sch. Sci., Univ. Aogaku)
ゆらぎの定理に基づく細胞張力ホメオスタシスに関する研究
Analyzing cellular tensional homeostasis from a physical point of viewShinji Deguchi, Yuika Ueda (Grad. Sch. Eng. Sci., Osaka Univ.)
制御理論に基づくアクチン細胞骨格の力学・生化学応答に関する理論解析
Modeling mechanochemical reaction of the actin cytoskeleton based on control theory
Eiji Matsumoto, Daiki Matsunaga, Shinji Deguchi (Grad. Sch. Eng. Sci., Osaka Univ.)– S152 –2Pos171*2Pos172

2Pos173*

2Pos174

2Pos175*

2Pos1762Pos177

脱水ストレス依存に細胞骨格様の線維やゲルを形成するクマムシタンパク質 CAHS による細胞の機械的強度の向上
Stress-dependent cell stiffening by tardigrade tolerance proteins CAHS reversibly forming
cytoskeleton-like filament networks and gels
Akihiro Tanaka1, Tomomi Nakano1, Kento Watanabe1, Kazutoshi Masuda2,3, Gen Honda2,3,
Shuichi Kamata1, Reitaro Yasui1, Satoshi Sawai1,3, Miho Yanagisawa2,3, Takekazu Kunieda1 (1Dept. ofBio. Sci., Grad. Sch. of Sci., Univ. of Tokyo., 2Komaba Inst. for Sci., Grad. Sch. of Arts and Sci., Univ. ofTokyo., 3Dept. of Basic Sci., Grad. Sch. of Arts and Sci., Univ. of Tokyo)
Jasplakinolide または Phalloidin が結合したアクチンフィラメントのゆらぎの違いを FRET 解析
により可視化した
Fluctuation difference in actin filaments bound Jasplakinolide or Phalloidin was visualized byusing FRETAi Takahashi1, Miku Nezasa2, Kuruto Toda2, Irfan Huzifah Ahmad2, Ichiro Nishikata4,
Kenji Kamimura3, Ikuko Fujiwara1, Hajime Honda1 (1Dept. of Matl. Sci. and Bioeng., Nagaoka Univ. of
Tech., 2Dept. Bioeng., Nagaoka Univ. of Tech., 3Dept. of Elect.Ctrl.Eng ., NIT. Nagaoka College,
4ACEM., NIT. Nagaoka college)
2 種の細菌アクチン MreB が駆動する最小の細胞運動システム
Minimal cell motility system driven by two bacterial actin MreB
Hana Kiyama1, Shigeyuki Kakizawa2, Yuya Sasajima1, O Yuhei Tahara1,3, Daichi Takahashi1,
Makoto Miyata1,3 (1Graduate school of Science, Osaka Metropolitan University, Japan, 2Bioproduction
Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Japan,
3OCARINA, Osaka Metropolitan University, Japan)
腫瘍微小環境におけるエクソソーム中 GRP78 タンパク質の増加が腫瘍進行を促進する
Increased GRP78 protein in exosomes in the tumor microenvironment promotes tumor
progression
Kanako Iha, Etsuro Ito (Department of Biology, Waseda University)
細胞の生死の網羅的・定量的理解に向けた、機械学習による細胞の運命予測
Predicting cell fates by image-based machine learning for comprehensive and quantitative
understanding of cell death and survival
Tomoaki Okaniwa1,2, Katsuyuki Shiroguchi1 (1RIKEN BDR, 2Grad. Sch. Frontier Biosciences, Osaka
Univ.)
Understanding the results of black box Convolution Neural Network to identify Follicular thyroid
cancerAbdul Halim Bhuiyan1,2, Jean-Emmanuel Clément3,4, Kentaro Mochizuki5, James Nick Taylor3,
Koji Tabata3,4, Yuta Mizuno1,3,4, Atsuyoshi Nakamura6, Yoshinori Harada7, Katsumasa Fujita5,8,9,
Tamiki Komatsuzaki1,3,4 (1Graduate School of Chemical Sciences and Engineering, Hokkaido University,
Sapporo, Japan., 2Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh.,
3Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science,
Hokkaido University, Sapporo, Japan, 4Institute for Chemical Reaction Design and Discovery, Hokkaido
University, Sapporo, Japan, 5Department of Applied physics, Graduate School of Engineering, Osaka
University, Japan, 6Graduate school of Information Science and Technology, Hokkaido University,
Japan, 7Department of Pathology & Cell Regulation, Kyoto Prefectural University of Medicine, Japan,
8Advanced Photonics and Biosensing Open Innovation Laboratory, AIST-Osaka University, Japan,
9Transdimensional Life Imaging Division, Osaka University, Japan)
Elucidation of macrophage’s spatial discrimination limit between target antigen and non-target
objects
Maiha Ando1, Dan Horonushi2, Sota Suzuki2, Masato Yamazaki1, Amane Yoshida2, Kenji Yasuda1,2(1Dept. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. &Eng., Waseda Univ.)– S153 –2Pos178

2Pos179

2Pos180

2Pos1812Pos182

2Pos183

2Pos184*

2Pos185

細胞内のタンパク質動態の 3 次元の流れとその定量化に関する研究
Research on three-dimensional flow of protein dynamics in cells and its quantification
Yuya Enokida (Grad. Sch. Comp. Sci. and Sys. Eng., Kyushu Inst. Tech)
海洋ビブリオ細胞分化におけるべん毛モーター回転制御因子 CheY の役割
Role of the flagellar motor-controlling factor CheY in cell differentiation of marine Vibrio
Karin Yamane1, Mayu Ito2, Masatoshi Nishikawa1,2, Hirotaka Tajima3, Ikuro Kawagishi1,2,3 (1Grad. Sch.
Eng., Hosei Univ., 2Dept. Frontier Biosci., Hosei Univ., 3Res. Cen. Micro-Nano Tech., Hosei Univ.)
海洋性ビブリオ菌において細胞極局在膜タンパク質 HubP はべん毛本数制御因子 FlhG の ATPase
活性を上昇させる
The polar landmark protein HubP enhances the ATPase activity of the flagellar number
regulator FlhG in Vibrio alginolyticus
Yuxi Hao1, Norihiro Takekawa2, Michio Homma1, Seiji Kojima1 (1Div. Biol. Sci., Grad. Sch. Sci.,
Nagoya Univ., 2Dept. Macromol. Sci., Grad. Sch. Sci., Osaka Univ.)
クラスリン軽鎖の細胞膜上での構造変化は被覆構造、そしてエンドサイトーシスを制御する
A conformational switch in clathrin light chain regulates lattice structure and endocytosis at theplasma membrane of mammalian cells
Kazuki Obashi, Kem Sochacki, Marie-Paule Strub, Justin Taraska (National Heart, Lung, and Blood
Institute, National Institutes of Health)
歯周病菌の Fim 線毛の先端タンパク質 FimC の構造
Structure of FimC, a tip protein of the Fim pilus in a gum disease bacterium Porphyromonas
gingivalis
Norihiro Takekawa1, Rei Kojima1, Mikio Shoji2, Katsumi Imada1 (1Grad. Sch. Sci., Osaka Univ.,
2Grad. Sch. Biomed Sci., Nagasaki Univ.)
細胞外小胞が引き起こす標的細胞でのシグナル伝達機構の解明：超解像顕微鏡法と 1 粒子追跡による研究
Intracellular signaling triggered by small extracellular vesicles as revealed by super-resolution
microscopy and single-particle tracking
Koichiro M. Hirosawa1, Yasunari Yokota2, Kenichi G. N. Suzuki1,3 (1iGCORE, Gifu Univ., 2Dept. Eng.,
Gifu Univ., 3CREST・JST)
アミノアシル tRNA 合成酵素 20 種の自己再生産と共役した DNA 複製系の構築
In vitro transcription/translation-coupled DNA replication through the regeneration of 20
aminoacyl-tRNA synthetases
Katsumi Hagino1, Norikazu Ichihashi1,2,3 (1Department of Life Science, Graduate School of Arts andScience, The University of Tokyo., 2Komaba Institute for Science, The University of Tokyo., 3ResearchCenter for Complex Systems Biology, Universal Biology Institute, The University of Tokyo.)
1 細胞内での CheB 局在変化による忌避応答および適応
Repellent response and adaptation through the CheB-localization in single E. coli cell
Taiga Deguchi1, Yumiko Uchida1, Yong-Suk Che1, Akihiko Ishijima1, Tatsuki Hamamoto2,
Hajime Fukuoka1 (1Grad. Sch. Frontier Biosci. Osaka Univ., 2OIST. Grad. Univ.)

生体膜・人工膜：構造・物性／Biological & Artificial membrane: Structure & Property
2Pos186*

2Pos187

膜融合性リポソーム膜のデザインのための系統的な膜特性解析
Systematic membrane characteristic analysis for the design of fusogenic liposome
Natsuumi Ito, Nozomi Watanabe, Yukihiro Okamoto, Hiroshi Umakoshi (Bio-Inspired Chemical
Engineering Laboratory / Division of Chemical Engineering / Graduate School of Engineering Science /Osaka University)
A Liposome Prepared by Microfluidic Device Vomits the Inner Solution
Jiajue Ji, Kayano Izumi, Ryuji Kawano (Department of Biotechnology and Life Science, University ofAgriculture and Technology)– S154 –2Pos188*

2Pos189

2Pos190

2Pos191*

2Pos192

2Pos193(3SGA-5) DNA ゲル骨格が決定する人工細胞の力学特性(3SGA-5) Cytoskeletons of self-assembled DNA regulate the mechanical properties of artificial
cells
Kazutoshi Masuda1, Fuyu Ohno2, Miho Yanagisawa1,2 (1College of Arts and Sciences, The University ofTokyo, 2Graduate school of Arts and Sciences, The University of Tokyo)
両親媒性ブロックポリマーを用いたポリマー二分子膜の作製
Preparation of planar bilayer polymer membrane using amphiphilic di- and tri-block copolymers
Hiroaki Kihara, Harune Suzuki, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo
University of Agriculture and Technology)
海水中で長期間安定に存在し得るリポソームの調製
Preparation for long-term stable liposomes in seawater
Kayano Izumi1, Keiichiro Koiwai2, Ryuji Kawano1 (1Tokyo University of Agriculture and Technology,
2Tokyo University of Marine science and Technology)
脂質二重膜へのエタノール分子の浸透に対する塩添加の影響：分子動力学法による検討
Effect of salt addition on the penetration of ethanol molecules into lipid bilayers: a molecular
dynamics study
Haru Kitaoka, Naoya Nishi, Yuko Yokoyama, Tetsuo Sakka (Graduate School of Engineering, Kyoto
University)
高分子液滴を用いた細胞サイズ依存的な相分離
Cell-size dependent phase separation in polymer droplet
Chiho Watanabe1,2, Tomohiro Furuki2, Yuki Kanakubo2, Fumiya Kanie2, Keisuke Koyanagi3,
Jun Takeshita2, Miho Yanagisawa2 (1Hiroshima Univ., 2Univ. Tokyo, 3Tokyo Univ. Agri. Tech.)
マガイニン 2 の膜相互作用に対する膜相転移の効果
Contributions of Membrane Phase Transitions to Interaction of Magainin 2 with Membrane
Ryoga Tsuji1, Munehiro Kumashiro2, Koichi Matsuo3 (1Grad. Sch. Adv. Sci. Eng., Hiroshima Univ.,
2Inst. Adv. Med. Sci., Tokushima Univ., 3HiSOR., Hiroshima Univ.)

生体膜・人工膜：ダイナミクス／Biological & Artificial membrane: Dynamics
2Pos194*

2Pos195*

2Pos1962Pos197*

生体膜の不均一性が分子の拡散性に与える影響
Effect of biological membrane’s heterogeneity on the diffusivity of molecules
Ken Sakamoto1, Takuma Akimoto2, Mayu Muramatsu3, Mark S. P. Sansom4, Ralf Metzler5,
Eiji Yamamoto6 (1Grad. Sch. Sci. Tech., Keio Univ., 2Dept. Phys., Tokyo Univ. Sci., 3Dept. Mech. Eng.,
Keio Univ., 4Dept. Biochem., Univ. Oxford, 5Inst. Phys. Astron., Univ. Potsdam, 6Dept. Syst. Des. Eng.,
Keio Univ.)
抗菌ペプチドによる膜細孔形成の分子シミュレーション研究
Molecular dynamics simulation study of membrane pore formation by antimicrobial peptides
Issei Kawabata1, Yusuke Miyazaki2, Wataru Shinoda2 (1Grad. Sch. Eng., Univ. Nagoya, 2RIIS., Univ.
Okayama)
光重合性脂質を用いた単分子/二分子のハイブリッド膜
Patterned monolayer/bilayer hybrid membrane composed of polymerized and natural lipids
Yasushi Tanimoto1, Fumio Hayashi2, Kenichi Morigaki3,4 (1Grad. Sch. Sci., OMU / Japanese, 2Grad.
Sch. Sci., Unv. Kobe / Japanese, 3Grad. Sch. Agr., Unv. Kobe / Japanese, 4Bios. R. C., Unv. Kobe)
分子動力学シミュレーションによるエンドソーム脱出分子機構の解明
Exploring Molecular Mechanism of Endosomal Escape: A Molecular Dynamics Study
Kana Shibata1, Akhil Pratap Singh1, Wataru Shinoda2 (1Grad. Sch. Eng., Univ. Nagoya, 2RIIS., Univ.
Okayama)– S155 –生体膜・人工膜：興奮・チャネル／Biological & Artificial membrane: Excitation & Channels
2Pos198*

2Pos199

2Pos200(1SFP-3) Mechanism study of antimicrobial peptide synergistic effects at the molecular levelby combining spectroscopy and electrochemical methods
Yuge Hou, Kaori Sugihara (Institute of Industrial Science, The University of Tokyo,)
電位依存性プロトンチャネルは細胞内 ATP による活性制御を受ける
Intracellular ATP controls the voltage-gated proton channel
Akira Kawanabe, Maki Takata, Yuichiro Fujiwara (Fac. Med., Kagawa Univ.)
Smooth 型 LPS を用いたグラム陰性細菌外膜模倣膜への抗菌ペプチドの作用評価
Reconstitution of smooth-type LPS as an outer membrane of Gram-negative bacteria
Wakana Hashimoto, Mitsuki Miyagi, Ryuji Kawano (Dep. of Biotech. and Life Sci., Tokyo Univ. of Agri.
and Tech.)

生体膜・人工膜：輸送・情報伝達／Biological & Artificial membrane: Transport & Signal transduction
2Pos201*

2Pos2022Pos203

脂質膜水透過現象の解析: アクアポリン水透過モデルとの比較
Water Permeation through the Lipid Membrane: from the Comparison with Aquaporin Study
Natsuki Fukuda1, Nozomi Watanabe1, Mizuki Teraoka2, Yukihiro Okamoto1, Hiroshi Umakoshi1(1Graduate School of Engineering Science, Osaka University., 2Doshisha Girl’s Senior High School.)
リポソーム型分子ロボットへの標的分子取込みTransport of the target molecules into liposome-type molecular robots
Harune Suzuki, Kohei Hayashi, Ryuji Kawano (Grad. Sch. Biotech & Life Sci., TUAT)
レセプター機能を有する膜中 DNA システムの開発
Construction of a membrane-spanning receptor-like DNA system
Sotaro Takiguchi, Ryuji Kawano (Dept. Biotech. Life Sci., Grad. Sch. Eng., Tokyo Univ. Agri. Tech.)

化学受容／Chemoreception
2Pos204

2Pos205*

2Pos206

細胞性粘菌の cAMP シグナルにおけるレチナールの効果
Effect of retinal on cAMP signaling in Dictyostelium discoideum
Kazuki Akiyama, Yusuke Morimoto (Kyusyu Institute of Technology (Grad. Sch. Comp. Sci. and Sys.
Eng., Kyushu Inst. Tech.))ヒトアセチルコリン受容体のアロステリック機構の振動分光研究
Vibrational spectroscopic study of Allosteric Mechanism on human muscarinic acetylcholine
receptor
Yuya Sugiura1, Kota Katayama1, Ryoji Suno2, Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst. Tech.,
2Kansai Medical University. Medical.)
センサーキナーゼ BaeS のインドール感知部位の同定
Identification of the indole-sensing region of the sensor kinase BaeS
Hirotaka Tajima1,2, Kenichiro Kashihara3, Kentaro Yamamoto4, Yoshiyuki Sowa1,2,3,
Ikuro Kawagishi1,2,3 (1Fac. of Biosci. and Appl. Chem., Hosei Univ., 2Res. Cent. for Micro-Nano Tech.,Hosei Univ., 3Grad. Sch. Sci. and Engin., Hosei Univ., 4Leprosy Res. Center, Nat. Ins. of Infectious
Diseases)– S156 –2Pos207

サルモネラクエン酸走性受容体 Tcp のリガンド認識における二価金属イオンの役割
Role of divalent metal cations in ligand recognition by the Salmonella citrate chemoreceptor Tcp
Fuga Omori1, Mariko Matsuda1, Katsumi Imada4, Hirotaka Tajima2,3, Yoshiyuki Sowa1,2,3,
Ikuro Kawagishi1,2,3 (1Grad. Sch. Sci. and Engin., Hosei Univ., 2Fac. of Biosci. and Appl. Chem., Hosei
Univ., 3Res. Cent. for Micro-Nano Tech., Hosei Univ., 4Grad. Sch. Sci., Osaka Univ.)

神経・感覚（細胞・膜蛋白質・分子）／Neuroscience & Sensory systems
2Pos208*

2Pos209

2Pos2102Pos211*

シナプス後肥厚におけるグルタミン酸受容体と PSD-95 のメソスコピックシミュレーション
Mesoscopic simulation of glutamate receptor and PSD-95 in postsynaptic density
Risa Yamada, Shoji Takada (Grad. Sch. Sci., Kyoto Univ.)
海馬興奮性ニューロンにおける NMDA 型イオンチャネル受容体に依存した双方向シナプス可塑性の大規模数理モデルによる研究
Mechanism underlying hippocampal long-term potentiation and depression based oncompetition between endocytosis and exocytosis of AMPAR
Tomonari Sumi1, Kouji Harada2 (1Research Inst. for Interdisciplinary Sci., Okayama Univ., 2Center for
IT-Based Edu., Toyohashi Univ. of Tech.)
高頻度で持続的なシナプス伝達をささえるシナプス小胞ナノスケール動態
Actin filaments restrict synaptic vesicle movement for high-frequency neurotransmission
Takafumi Miki (Grad. Sch. Brain Sci., Doshisha Univ.)
細胞内輸送関連分子の新規解析手法の開発と病態モデルへの応用
A new approach to analysis of intracellular trafficking-related molecules using Cellprofiler andImageJ in combination
Akito Hattori1, Etsuro Ohta2,3,4,5, Makiko Nagai6, Kazuya Iwabuchi1, Hideyuki Okano5 (1Program in
Cellular Immunol, Gradu Sch Med Sci Kitasato Univ, 2R&D center for Cell Design, Institute forRegenerative Medicine and Cell Design, Kitasato Univ, 3Dept ImmunolⅡ, Kitasato Univ of Allied HealthSci, 4Div Clinical Immunol, Gradu Sch Med Sci Kitasato Univ, 5Dept Physiol Keio Univ Sch Med, 6Dept
Neurol, Kitasato Univ Sch of Med)

神経回路・脳の情報処理／Neuronal circuit & Information processing
2Pos2122Pos2132Pos214

ダブル Y 字型アガロース微細構造における神経突起同士の相互作用
Interactions of two elongating neurites in double Y-shaped agarose microstructure
Nanami Abe1, Yuhei Tanaka2, Ryohei Yamazaki2, Yuri Kamiya1, Haruki Watanabe2, Kenji Yasuda1,2(1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Univ. Waseda, 2Dept. Pure & Appl. Phys., Grad. Sch.
Adv. Sci. & Eng., Univ. Waseda)
カルシウムイメージングによるアガロースマクロチャンバー内の神経回路活動の可視化
Visualization of neural circuit activity in agarose micro chamber by calcium imaging
Rika Fuchikami, Masahito Hayashi, Tomoyuki Kaneko (FB, Grad. Sch. Sci. &Eng., Hosei Univ.)
海馬が合成する男性・女性ホルモンやストレスホルモンは記憶シナプスを蛋白キナーゼ信号系
で制御する
Kinase-dependent modulation of neuronal synapses by hippocampus-synthesized androgen,estrogen and stress hormone
Suguru Kawato1,2, Mika Soma1,2, Mari Ogiue-Ikeda1,2, Saria Mabashi2, Ayako Takasu3, Minoru Saito2(1Grad. Sch. Medicine, Juntendo Univ., 2Coll. Hum. Sci., Nihon Univ., 3Grad. Sch. Integ. Bas. Sci., Nihon
Univ.)– S157 –2Pos215

2Pos216

2Pos217

2Pos218

2Pos219

2Pos220

ミトコンドリア β 酸化に関与する HADH が線虫の介在ニューロンにおいて低温馴化を制御する
HADH involved in mitochondrial β-oxidation regulates temperature acclimation in interneuronsof C.elegans
Akihisa Fukumoto1, Misaki Okahata1, Yohei Minakuchi2, Atsushi Toyoda2, Akane Ohta1,
Atsushi Kuhara1,3 (1Grad. Sch. Sci., Konan Univ, 2Natl. Inst, of Genetics, Japan, 3PRIME, AMED)
全身を周回する神経回路が腸の脂質含量を調節する
Whole-body neural circuit regulates intestinal fat storage
Haruka Motomura1,2, Makoto Ioroi1,2, Kazutoshi Murakami1,2, Atsushi Kuhara1,2,3, Akane Ohta1,2(1Grad. Sch of Nat. Sci., Konan Univ., 2Ins. integrative Neurobio., Konan Univ., Japan, 3PRIME, AMED)
環境の酸素情報が温度応答性に影響を与えることで低温馴化多様性が決定される
Cold acclimation diversity is determined by oxygen information, which affect neural activity ofthermo sensory neuron in C. elegans
Misaki Okahata1, Sawako Yoshina2, Yohei Minakuchi3, Atsushi Toyoda3, Shohei Mitani2, Toru Miura1,
Akane Ohta1, Atsushi Kuhara1,4 (1Inst. for Integrative Neurobio., Konan Univ., 2Tokyo Women’s Med.
Univ., 3National Inst. of Genetics, 4PRIME, AMED)
ミミズ非連合学習におけるセロトニンシグナル
Serotonin signaling in non-associative learning in earthworm
Yoshiichiro Kitamura, Toshifumi Yakuwa, Daichi Morikawa (Dept Math Sci Phys, Col Sci Eng, Kanto
Gakuin Univ)
異種混合培養神経回路網における神経情報伝達
Functional connections in a heterologous cultured chimera neuronal network
Ayumi Nishikawa, Suguru N. Kudoh (Dep. of Engineering, Kwansei Gakuin University)
網羅的定量的光計測によるマウス前頭葉前帯状皮質の興奮伝播の解析:膜電位感受性色素 VSD による
Analysis of neural activity propagation in the mouse prefrontal cortex using comprehensive
quantitative optical recording: VSD study
Takashi Tominaga1,2, Pooja Gusain3, Makiko Taketoshi1, Yoko Tominaga1 (1Inst. Neurosci., Tokushima
Bunri Univ., 2Kagawa Sch Pharm., Tokushima Bunri Univ., 3Dept. Ophth, Sch Med, Keio Univ)

行動／Behavior
2Pos2212Pos222

2Pos223

2Pos224

咽頭筋のアミノ酸トランスポーター SLC46 は C. elegans の低温耐性を制御する
Amino acid transporter SLC46 in pharyngeal muscle regulates cold tolerance of C. elegans
Serina Yamashiro1, Satomi Mizuno1, Haruka Motomura1, Akane Ohta1, Atsushi Kuhara1,2 (1Laboratoryof Molecular and Cellular Regulation Graduate school of Natural Science Konan University, 2PRIME,
AMED)
蟻の探索行動における 3 次元的空間知覚
Three dimensional perception on ant foraging
Tomoko Sakiyama (Faculty of Science and Engineering, Soka University)
タイリクバラタナゴの赤色に対する特異な行動
Unusual behavior of rosy bitterlings in response to red coloration
Ririka Yamamoto1, Rio Yoshizawa1, Rikiya Ogawa2 (1Osaka Prefecture Tondabayashi High School,
2Rikijuku Science School)
ミクロ社会とマクロ社会におけるカラス属の社会行動が示すカラスの社会性
Crows (corvus) society based on crows' behaivor in micro-society and macro-society
Haruki Kon, Kosei Ando, Aoba Sasaki, Hina Nakamura (Sapporo Kaisei secondary school)– S158 –光生物：視覚・光受容／Photobiology: Vision & Photoreception
2Pos225

2Pos226*

2Pos227*

2Pos228*

2Pos229

2Pos230*

2Pos2312Pos232

2Pos233*

2Pos234

シアノバクテリオクロム RcaE におけるユニークな C15‐E,syn 型ビリン発色団のラマン分光法
による研究
Raman Spectroscopy of an Atypical C15‐E,syn Bilin Chromophore in Cyanobacteriochrome
RcaE
Yuji Okuda1, Risako Miyoshi1, Takanari Kamo2, Tomotsumi Fujisawa1, Takayuki Nagae3,
Masaki Mishima3, Toshihiko Eki2, Yuu Hirose2, Masashi Unno1 (1Fac.Sci.Eng.,Saga.Univ, 2Toyohashi
Univ. of Tech. Appl. Chem. & Life Sci., 3Tokyo Univ. of Pharmacy and Life Sciences Dep. Mol. Biophys.)
青色光センサータンパク質 SyPixD の C 末端領域による 10 量体構造の安定化
Stabilization of decamer structure by the C-terminal region of the blue light sensor protein
SyPixD
Shunrou Tokonami, Yusuke Nakasone, Masahide Terazima (Grad. Sch. Sci., Univ. Kyoto)
新奇塩化物イオンポンプロドプシンの輸送メカニズム研究
Study on the transport mechanism of the novel chloride-ion pump rhodopsin
Tomohiro Ishizuka1, Kano Suzuki2, Yuma Kawasaki1, Masae Konno1,3, Takeshi Murata2,4,
Keiichi Inoue1 (1ISSP, Univ. of Tokyo, 2Grad. Sch. Sci., Chiba Univ., 3JST, PRESTO, 4MPRC, Chiba
Univ.)
クリプトクロムが触媒する DNA 光修復反応の時間分解分光解析
Time-resolved spectroscopic analysis of DNA photorepair reaction catalyzed by cryptochrome
Tatsumi Maeno1, Daichi Yamada1, Ai Kadono1, Junpei Yamamoto2, Minoru Kubo1 (1Grad. Sch. Sci.,
Univ. Hyogo, Japan, 2Grad. Sch. Eng. Sci., Osaka Univ., Japan)
光と苦味のセンサーとしてはたらくキイロショウジョウバエ Rh7 の赤外分光研究
FTIR study of Drosophila Rh7, a light and bitter taste sensor
Kouhei Watanabe, Kota Katayama, Hideki Kandori (Grad. Sch. Eng., Nagoya Inst.Tech.)
霊長類青感受性視物質の 200 K 以上での赤外分光解析
FTIR study of primate blue-sensitive cone pigment at >200 K
Yosuke Mizuno1, Kota Katayama1, Hiro Imai2, Hideki Kandori1 (1Grad. Sch. Eng, Nagoya Inst. Tech.,
2Center for the Evolutionary Origins of Human Behavior, Kyoto University)
全トランス型から 11 シス型の光反応を示す新規微生物ロドプシンの分光解析
Spectroscopic analysis of novel microbial rhodopsin showing photoreaction from all-trans- to
11-cis-retinal
Mako Aoyama1, Kota Katayama1, Rei Abe-Yoshizumi1, Masahiro Sugiura1, Andrey Rozenberg2,
Igor Kaczmarczyk3, Donna Matzov3, Takashi Nagata4, Moran Shalev-Benami3, Oded Béjà2,
Keiichi Inoue4, Yuji Furutani1, Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst. Tech., 2Technion – IsraelInst. Tech., 3Weizmann Inst. Sci., 4ISSP, Univ. Tokyo)
異なる位置にカウンターイオンを持つクラゲオプシンの光異性化機構解析
Spectroscopic study of photoisomerization mechanism of Jellyfish Opsin having counterion at
different position
Shino Inukai1, Kota Katayama1, Mitsumasa Koyanagi2, Akihisa Tereakita2, Hideki Kandori1 (1Grad.
Sch. Eng., Nagoya Inst. Tech., 2Grad. Sch. Sci., Osaka Metro. Univ.)
固体 NMR を用いた Zn2+結合型 TaHeR の脂質二重膜中の構造解析
Solid-state NMR study of membrane embedded TaHeR in the presence of Zn2+
Sari Kumagai1, Shibuki Suzuki1, Kota Katayama2, Hideki Kandori2, Izuru Kawamura1 (1Grad. Sch.
Eng. Sci., Yokohama Natl. Univ., 2Dep. Life Sci. Appl. Chem., Nagoya Inst. Technol.)
霊長類の緑色感受性タンパク質の原子構造決定に向けて
Toward determining the atomic structure of primate green cone pigment
Sayaka Ohashi1, Kota Katayama1, Ryoji Suno2, Nipawan Nuemket3,4, So Iwata3,4, Eriko Nango4,5,
Takuya Kobayashi2, Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst.Tech., 2Kansai Medical University,
3Kyoto University, 4Japan Synchrotron Radiation Research Institute, 5Tohoku University)– S159 –2Pos235

2Pos236

2Pos237

RcPYP と PBP 相互作用における表面電荷の効果
Effects of surface charge on RcPYP and PBP interactions
Yoichi Yamazaki1, Yoko Narahara1, Hironari Kamikubo1,2 (1NAIST, MS, 2NAIST, CDG)
固体 NMR による膜中 TAT ロドプシンの構造解析
Solid-state NMR study of membrane-embedded TAT rhodopsin
Sui Arikawa1, Teppei Sugimoto2, Kota Katayama2, Hideki Kandori2, Izuru Kawamura1 (1Grad. Sch.
Eng. Sci., Univ. Yokohama Natl., 2Dep. Life Sci. Appl. Chem., Nagoya Inst. Technol.)
低温ラマン分光法による photoactive yellow protein の L 中間体の構造解析
Structural analysis of the L intermediate in the photoactive yellow protein by low-temperature
Raman spectroscopy
Shota Kawasaki1, Tomotsumi Fujisawa1, D. Hoff Wotuer2, Masashi Unno1 (1Fac. Sci. Eng., Saga Univ.,
2Oklahoma state Univ.)

光生物：光合成／Photobiology: Photosynthesis
2Pos238

2Pos239

2Pos240*

2Pos2412Pos2422Pos243PELDOR 法により決定した光化学系Ⅱの 2 つの Mn2+親和サイト
Location of the two high-affinity Mn2+ site in photosystem II detected by PELDOR
Hiroyuki Mino1, Mizue Asada1,2 (1Grad. Sch. Sci., Nagoya Univ., 2Inst. Molecular Sci.)
光化学系 II におけるストロマおよびルーメン側における摂動が第一キノン電子受容体 QA の酸化還元電位に及ぼす影響
Effects of stromal and lumenal side perturbations on the redox potential of the primary quinone
QA in photosystem II
Yuki Kato, Takumi Noguchi (Grad. Sch. Sci, Nagoya Univ.)
一分子過度吸収測定による光合成光捕集アンテナ複合体のダイナミクスとエネルギー移動の相関解析
Single-molecule transient absorption spectroscopy of energy transfer in photosynthetic antennacomplex
Shun Arai1, Tomomi Inagaki2, Chihiro Azai2, Toru Kondo1 (1Dept. of Life Sci. and Tech., Tokyo Tech.,
2Grad. Sch. Life Sci., Ritsumeikan Univ.)
光合成カロテノイドシフォナキサンチンにおける非共役官能基の共役系への影響
Effect of the non-conjugated functional group on the optical properties of a photosynthetic
carotenoid, siphonaxanthin
Soichiro Seki1, Kazuhiro Yoshida1, Yumiko Yamano2, Naohiro Oka3, Mitsuru Sugisaki1, Ritsuko Fujii1,4(1Grad. Sch. Sci., Osaka Metropolitan Univ., 2Comp. Edu. Res. Cntr, Kobe Pharmaceutical Univ., 3BioInnovation Res. Cntr, Tokushima Univ., 4Res. Cntr. Artif. Photosynth., Osaka Metropolitan Univ.)
光化学系Ⅱにおける水分解マンガンクラスターの光構築機構の時間分解赤外分光解析
Time-resolved infrared study on the mechanism of photoassembly of the water-oxidizing
Mn4CaO5 cluster in photosystem Ⅱ
Shunya Watanabe, Yuichiro Shimada, Takumi Noguchi (Grad. Sch. Sci., Nagoya Univ.)
光化学系 II の酸素発生中心における S2 状態の中間体構造の DFT と CC 法による解析
DFT and DLPNO-CC calculation of relative stability and electronic states in the S2 state of theCaMn4O5 cluster of the OEC of the PSII
Koichi Miyagawa1, Takashi Kawakami2,3, Mitsuo Shoji1, Hiroshi Isobe4, Kizashi Yamaguchi3,5,
Yasuteru Shigeta1 (1Center for Computational Sciences, University of Tsukuba, 2Graduate School of
Science, Osaka University, 3RIKEN Center for Computational Science, 4Research Institute forInterdisciplinary Science, Okayama University, 5Center for Quantum Information and Quantum Biology,
Osaka University)– S160 –2Pos244

2Pos245

分子動力学シミュレーションによる紅色細菌の光捕集アンテナ LH2 の吸収スペクトルの解析
The analysis of absorption spectra of light-harvesting antenna LH2 in purple bacteria bymolecular dynamics simulation
Shunsuke Yabu1, Hirofumi Sato1,2, Masahiro Higashi1 (1Graduate School of Engineering, Kyoto Univ.,
2FIFC, Kyoto Univ.)
X 線自由電子レーザーを用いた解析による光化学系 II の基質水分子の取り込みと水分子の酸化に関する構造的知見
Structural insights into the substrate water delivery and water oxidation in photosystem II byanalysis with an X-ray free-electron laser
Michi Suga, Yoshiki Nakajima, Hongjie Li, Jian-Ren Shen (Okayama Univ)

光生物：光遺伝学・光制御／Photobiology: Optogenetics & Optical Control
2Pos246*

2Pos247*

2Pos248*2Pos249*

2Pos250

2Pos251

2Pos252

2Pos253

内向きおよび外向きプロトンポンプロドプシンの駆動力の解明
Driving force of inward and outward proton pump rhodopsins
Akari Okuyama, Shoko Hososhima, Satoshi Tsunoda, Hideki Kandori (Grad. Sch. Eng., Nagoya Inst.
Tech.)
Ca2+結合型 TAT ロドプシンの分光研究
Spectroscopic study of TAT rhodopsin bound with Calcium ion
Teppei Sugimoto, Kota Katayama, Hideki Kandori (Graduate school of Engineering, Nagoya institute oftechnology)
LED 光源を用いた微生物型ロドプシン AR3 による膜電位の長時間イメージング
Long-term membrane voltage imaging by microbial rhodopsin AR3 with LED light source
Shiho Kawanishi1, Keiichi Kojima2, Atsushi Shibukawa1, Masayuki Sakamoto3, Yuki Sudo2 (1Grad.
Sch., Med. Dent. & Pharm. Sci., Okayama Univ., 2Grad. Sch., Med. Dent. & Pharm. Sci., Okayama
Univ., 3Grad. Sch., Biostudies, Kyoto Univ.)
ポンプ型チャネルロドプシン ChRmine のクライオ電子顕微鏡構造解析と次世代光遺伝学ツール開発
Cryo-EM structural analysis of pump-like channelrhodopsin ChRmine and structure guided
engineering
Koichiro Kishi1, Yoon Kim2, Masahiro Fukuda1, Masatoshi Inoue2, Tsukasa Kusakizako3, Peter Wang2,
Charu Ramakrishnan2, Eamon Byrne2, Elina Thadhani4, Joseph Paggi4, Toshiki Matsui1,
Keitaro Yamashita5, Takashi Nagata6, Masae Konno6, Sean Quirin2, Maisie Lo2, Tyler Benster2,
Tomoko Uemura7, Kehong Liu7, Mikihiro Shibata8, Norimichi Nomura7, So Iwata7, Osamu Nureki3,
Ron Dror4, Keiichi Inoue6, Karl Deisseroth2, Hideaki Kato1 (1Komaba Inst. Sci., Univ. Tokyo, 2Dept.
Bioeng., Stanford Univ., 3Dept. Bio. Sci., Univ. Tokyo, 4Dept. Comp. Sci., Stanford Univ., 5MRC Lab. Mol.
Biol., 6ISSP Univ. Tokyo, 7Dept. Cell Biol., Kyoto Univ., 8Inst. Front. Sci. Init., Kanazawa Univ.)
光活性化アデニル酸シクラーゼの活性化に伴う構造変化の解明
Structural changes of adenylate cyclase from Oscillatoria acuminata in response to blue lightstimulation
Yuki Kitamura, Toru Ide, Minako Hirano (Grad. Sch. Health Sys,. Okayama Univ.)
藻類シオミドロが持つ 4 種の Aureochrome の類似性と多様性
Similarity and Diversity of aureochromes, EsAu1-EsAu4, in a brown alga, E. siliculosus.
Yuta Nagano, Yumiko Adachi, Osamu Hisatomi (Grad. Sch. Sci., Univ. Osaka)
近赤外光で駆動可能なバイオアクチュエータの創製
Creation of Bioactuators Drivable by Near-Infrared Light
Daisuke Maemura, Son Le The, Mari Takahashi, Kazuaki Matsumura, Shinya Maenosono (Sch. Mater.
Sci., JAIST)
In vivo optogenetic system to control deep tissue insulin signaling
Qi Dong, Mizuki Endo, Takeaki Ozawa (Grad. Sch. Sci., Univ. Tokyo)– S161 –生命の起源・進化／Origin of life & Evolution
2Pos254

2Pos255*

2Pos256

2Pos257

2Pos258*

2Pos259

プロトセルの適応度地形
Fitness Landscape of Protocell
Akiko Baba1, Keidai Sato1, Kazuki Yokoyama1, Ulf Olsson2, Masayuki Imai1 (1Grad. Sch. Sci., Univ.
Tohoku, 2Grad. Sch. Sci., Univ. Lund)
Host-Parasite 分子複製体が織りなす複製反応ネットワークの複雑化過程とその性質
Complexification Process and Property of Replication Network by Host-Parasite Molucular
Replicator
Rikuto Kamiura1, Ryo Mizuuchi2,3, Norikazu Ichihashi1,2 (1Grad. Sch. Arts and Sci., Univ. Tokyo,
2Komaba inst., Univ. Tokyo, 3JST, PRESTO)
無細胞翻訳系を用いた DNA 自己複製により成長する相分離液滴の開発
Phase-separated Dex droplets grow coupled with internal DNA self-replication
Moe Yabuta, Yoshihiro Minagawa, Hiroyuki Noji (Dept. App. Chem., Grad. Sch. Eng., Univ. Tokyo)
試験管内の DNA 複製、転写、翻訳反応は最適条件が異なる
Different conditions are optimal for in vitro DNA replication, transcription, and translation
Kaito Seo1, Norikazu Ichihashi1,2,3 (1Grad. Sch. Arts. Sci., Univ. Tokyo, 2Komaba Inst. Sci., Univ. Tokyo,
3Res. Cen. Complex Syst. Bio., Univ. Bio. Inst., Univ. Tokyo)
RNA 自己複製系を用いた RNA ゲノム再編成を伴う RNA 集団の進化の観察
Observation of RNA population evolution with RNA genome reorganization using RNA selfreplication system
Kensuke Ueda1, Ryo Mizuuchi2, Norikazu Ichihashi1,2,3 (1Graduate School of Arts and Science, The
University of Tokyo, 2Komaba Institute for Science, The University of Tokyo, 3Universal Biology Institute,
The University of Tokyo)
Trp を含まない酵素群によって構成される解糖系に依存して生育する大腸菌の作成に向けた活性測定
Activity measurement for the creation of Escherichia coli dependent on glycolysis composedof a group of Trp-free enzymes
Naosato Takagi1, Mana Hashimoto1, Akifumi Nishida1, Kenji Tsuge2, Daisuke Kiga1 (1Faculty of
Science and Engineering, Waseda University, 2Graduate School of Science, Technology and Innovation,
Kobe University)

ゲノム生物学：ゲノム解析／Genome biology: Genome analysis
2Pos260*

2Pos261(2SHP-4) 新規遺伝子の誕生と機能獲得の進化メカニズムに迫るゲノム計算科学：バイオイン
フォマティクスのその先に遺伝子の本質を探求する(2SHP-4) How do de novo genes evolve and acquire function?: Computational genomics torevisit the nature of genes beyond bioinformatics
Shun Yamanouchi1, Wataru Iwasaki1,2 (1Grad. Sch. Sci., Univ. Tokyo, 2Grad. Sch. Front. Sci., Univ.
Tokyo)
PLA2 産生に関与する遺伝子と経路の同定
Identification of the genes and pathways responsible for PLA2 production
Hiroki Oura1, Eri Hayashi1, Yuto Kimura1, Yusuke Nomura1, Satoko Nakamura3, Norimasa Kashiwagi3,
Chiaki Ogino3, Shuichi Hirose2, Wataru Nemoto1 (1Dept. Sch. & Tech., Tokyo Denki Univ, 2NAGASE R &D Center NAGASE & CO, 3Org. of Adv Sci & Tec., Kobe Univ)– S162 –2Pos262*

Sequel II を用いた単一インフルエンザウイルス集団中のゲノム配列分布測定
Heterogeneity of Genetic Sequence within Population in Single Plaque of Influenza Virus
Revealed by Sequel II analysis
Kenji Tamao1, Masayuki Suetsugu2, Hiroyuki Noji1, Kazuhito Tabata1 (1Appl. Chem., Grad. Sch. Eng.,
Univ. Tokyo, 2Dept. Life. Sci., Col. Sci., Univ. Rikkyo)

ゲノム生物学：ゲノム構造／Genome biology: Genome structure
2Pos263*

2Pos2642Pos265*

2Pos266

マウス胚性幹細胞の初期分化過程における X 染色体のエピゲノム構造変化は Xic 対合を促進する
Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation
process from embryonic stem cell of mouse
Tetsushi Komoto, Masashi Fujii, Akinori Awazu (Grad. Sch. Integrated Sciences for Life, Univ.
Hiroshima)
Bayesian inference of chromatin folding from Hi-C data and application to enhancer-promoter
communication in the Nanog locus
Giovanni Bruno Brandani, Chenyang Gu, Soundhara Rajan Gopi, Shoji Takada (Grad. Sch. Sci., Univ.
Kyoto)Polymer physics model of chromatin dynamics during early embryogenesis in Caenorhabditis
elegans
Yesbolatova Aiya1, Akatsuki Kimura1, Takahiro Sakaue2 (1Grad. Univ. for Adv. Stud., SOKENDAI,
National Institute of Genetics, 2Aoyama Gakuin University, Department of Physics and Mathematics)
Building a Coarse-grained Model of Chromatin
Justin Chan, Hidetoshi Kono (Molecular Modelling and Simulation (MMS) Team, National Institutes for
Quantum Science and Technology (QST))

生命情報科学：構造ゲノミクス／Bioinformatics: Structural genomics
2Pos267

2Pos268

2Pos269

PDB における ATP アーゼ複合体の構造変化
Structural changes of ATPase complexes in the PDB
Ryotaro Koike (Grad. Sch. Info., Nagoya Univ.)
Accurate modeling and mechanistic investigation of the complexes of the SRK/SP11 proteinsof Brassicaceae
Hanting Jiang1, Kentaro Shimizu1, Tohru Terada1, Yoshitaka Moriwaki1, Kohji Murase2,
Seiji Takayama2 (1Dept. of Biotechnol., Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo, 2Dept. of Appl.
Biol. Chem., Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo)
AlphaFoldDB の予測立体構造と既知の実験立体構造との構造比較
Structure comparison of predicted 3D models in AlphaFoldDB with known experimentally
determined 3D structures
Takeshi Kawabata, Kengo Kinoshita (Grad.Sch.Info.Sci.,Tohoku Univ.)

生態／環境／Ecology & Environment
2Pos270

大和川水系石川におけるオオシマドジョウの生活史
Life History of Cobitis sp. BIWAE Type A in the Ishi River in the Yamato River System
Teppei Sakurai1, Rikiya Ogawa2 (1Osaka Prefecture Tondabayashi High School, 2Rikijuku Science
School)– S163 –2Pos271

2Pos272

石川の魚類相の変遷とその要因についての一考察
Transition of fish fauna in Ishi River and a consideration about that factors
Shohei Umegawa1, Kyoka Matsuo1, Rikiya Ogawa2 (1Osaka Prefecture Tondabayashi High School,
2Rikijuku Science School)
自然浄化に必要なものはWhat is needed for natural purification?
Kyoka Matsuo1, Cocona Okada1, Rikiya Ogawa2 (1Osaka Prefecture Tondabayashi High School,
2Rikijuku Science School)

数理生物学／Mathematical biology
2Pos273*

2Pos274

2Pos275*

2Pos276*2Pos277

2Pos278*2Pos279

皮膚疾患の環状紅斑を対象とした数理解析による炎症調節機構の解明
Mathematical analysis of erythema annulare to elucidate the pattern formation mechanism ofskin inflammation
Maki Sudo, Koichi Fujimoto (Grad. Sch. Sci., Osaka University)
嗅覚系における匂い物質・受容体の多対多の相互作用による類似匂い混合物の識別に関する理論的解析
Mathematical analysis of the discrimination of odorant mixtures via collective interactions ofmultiple odorants and olfactory receptors
Karin Suwazono1, Tetsuya J. Kobayashi2 (1Dept. Biophys. and Biochem., Fuc. Sci., Univ. Tokyo, 2Inst.
Ind. Sci., Univ. Tokyo)
免疫系における予測符号化に基づく適応的な抗原の有害/無害識別Adaptive discrimination between harmful and harmless antigens based on predictive coding in
immune system
Kana Yoshido1, Naoki Honda1,2,3 (1Grad. Sch. of Biostudies, Kyoto Univ., 2Grad. Sch. of Integrated
Sciences for Life, Hiroshima Univ., 3ExCELLS, NINS)
化学反応ネットワークの改変がダイナミクスに与える影響の解析
Analyzing the effect of modifications to the chemical reaction network on dynamics
Atsuki Hishida1, Atsushi Mochizuki2 (1Grad. Sch. Sci., Univ. Kyoto, 2Inst. Life Med. Sci, Kyoto Univ.)
新しいパターン伝播機構: 曲率により駆動されるパターン伝播
New mechanism of pattern propagation: Pattern propagation driven by surface curvature
Ryosuke Nishide, Shuji Ishihara (Grad. Sch. Arts and Sci., Univ. Tokyo)
ゲノム縮小は内部共生の進化を加速するのだろうか？
Does Genome Reduction Accelerate Evolution of Endosymbiosis?
Yuki Kanai1, Chikara Furusawa1,2 (1Grad. Sch. Sci., Univ. Tokyo, 2BDR, Riken)
A mathematical model for emergence of polar order induced by contact following locomotion ina multicellular system
Biplab Bhattacherjee, Masayuki Hayakawa, Tatsuo Shibata (Laboratory for Physical Biology, BDR,RIKEN)

非平衡・生体リズム／Nonequilibrium state & Biological rhythm
2Pos280

ミクロ経済学としての代謝制御の理解：ワールブルク効果とギッフェン財を例としてMicroeconomics of Metabolism: The Warburg effect as Giffen behavior
Jumpei Yamagishi, Tetsuhiro Hatakeyama (Grad. Sch. of Arts and Sci., Univ. Tokyo)– S164 –2Pos281

2Pos282

2Pos283

2Pos284

Growing and competing cell colonies in a hybrid mechanochemical model
Jintao Li1, Simon Kaspar Schnyder1,2, Matthew S. Turner3, Ryoichi Yamamoto1 (1Department ofChemical Engineering, Kyoto University, Kyoto 615-8510, Japan, 2Institute of Industrial Science, The
University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan, 3Department of Physics,
University of Warwick, Coventry CV4 7AL, United Kingdom)
人工細胞内で再構成された細胞分裂面を決定する反応拡散波の動態と周期の制御
Tuning dynamics and period of a reaction-diffusion wave for cell division in artificial cells
Sakura Takada1, Natsuhiko Yoshinaga2,3, Nobuhide Doi1, Kei Fujiwara1 (1Dept. Biosci. Info., Keio
Univ., 2AIMR, Tohoku Univ., 3MathAM-OIL, AIST)
無細胞発現系における液滴形成のダイナミクス
Dynamics of droplet formation in cell-free expression systems
Shuzo Kato1, David Garenne2, Vincent Noireaux2, Yusuke Maeda1 (1Dept. Phys., Kyushu Univ., 2Sch.
Phys. Astro., Univ. of Minnesota)
接着力を取り入れたアクティブブラウン粒子モデルによる細胞集団運動のモデル化
Adhesive Active Brownian Particle Model for Collective Cell Motion
Sota Shimamura1, Nen Saito2, Shuji Ishihara1 (1Grad. Sch. Arts and Sci., U. Tokyo., 2Grad. Sch. ofIntegrated Sci. for Life, Hiroshima Univ.)

計測／Measurements
2Pos285*

2Pos286*

2Pos287*

2Pos288*

2Pos289*2Pos290*2Pos291*

ダイヤモンド量子センサによる単一細胞測定へ向けたピコリットル溶液 NMR 装置の開発
Development of pico-litter liquid NMR for single cell measurement by using diamond quantum
sensorKohki Morita1, Izuru Ohki1,2, Masanori Fujiwara1, Yuta Nakano3, Norio Tokuda3, Norikazu Mizuochi1,4(1ICR, Kyoto Univ., 2QST, 3NanoMaRi, Kanazawa Univ., 4CSRN, Kyoto Univ.)
In vitro およびヒト生細胞中における超硫黄分子と S8 のラマン解析
Raman analyses of supersulfides and S8 in vitro and in human living cells
Lisa Kageyama1, Shinji Kajimoto1,2, Shinya Tahara1, Takakazu Nakabayashi1 (1Graduate School of
Pharmaceutical Sciences, University of Tohoku., 2JST PRESTO)
Single Exosome 内包 miRNA 検出に向けた半導体ナノポアを用いた 1 粒子内包物検出法の開発
Development of a single-particle inclusions detection method by solid-state nanopore for miRNAin single exosome detection
Takumi Uchida, Hirohito Yamazaki, Ryo Iizuka, Sotaro Uemura (Grad. Sch. Sci., The Univ. of Tokyo)
Nanopore sensing of femtomolar DNAs using the excess complementary probes
Nanami Takeuchi, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology)
ガラスピペットナノポアによるエクソソームの電気的検出Electrical detection of exosomes by a glass capillary nanopore
Kohei Hayashi, Ryuji Kawano (Department of Biotechnology and Life Science, Tokyo University ofAgriculture and Technology)(2SDA-4) Nanopore direct determination of DNA methylation and demethylation intermediates
Ping Liu1, Masayuki Honda1, Ryuji Kawano2 (1Department of Food and Energy Systems Science, Tokyo
University of Agriculture and Technology, 2Institute of Engineering, Tokyo University of Agriculture andTechnology)
原子間力顕微鏡による神経管閉鎖中のホヤ胚の 1 細胞力学特性の測定
Mechanical properties of single cells in ascidian embryo during neural tube closure measured
by atomic force microscopy
Yosuke Tsuboyama, Yuki Miyata, Takaharu Okajima (Graduate School / Faculty of Information Scienceand Technology, Hokkaido University)– S165 –2Pos292

2Pos293

Optimization of protocols for metabolomics studies of human breast milk samples using
benchtop NMR
Jiaxi Jiang1, Zhiyan Hu1, Li Gan1, Zihao Song1, Yuki Ohnishi1, Seiji Osada2, Hiroyuki Kumeta1,
Yasuhiro Kumaki1, Kazuo Yamauchi3, Tomoyasu Aizawa1 (1Grad. Sch. Life Sci., Hokkaido Univ.,
2Nakayama Co.,Ltd., 3IAS, OIST)
α-グルコシダーゼ阻害物質を含むクワ葉の投与によるマウス腸内環境への影響の NMR メタボロ
ミクス解析
NMR metabolomics of administration of mulberry leaves containing α-glucosidase inhibitors on
the intestinal environment of mice
Li Gan, Yuga Inamura, Zihao Song, Yuki Ohnishi, Yasuhiro Kumaki, Tomoyasu Aizawa (Grad. Sch. Life
Sci., Univ. Hokkaido)

バイオイメージング／Bioimaging
2Pos294*

2Pos295*

2Pos2962Pos297*

2Pos298

2Pos299*

Spatiotemporal Dynamics of Small Extracellular Vesicle Nanotopology in Response to
Physicochemical Stresses Revealed by HS-AFM
Elma Sakinatus Sajidah1, Lim Keesiang2, Tomoyoshi Yamano3, Takeshi Yoshida2,3, Akiko Kobayashi4,
Masaharu Hazawa2,4, Rikinari Hanayama2,3, Toshio Ando2, Richard W. Wong1,2,4 (1Division of Nano Life
Science in the Graduate School of Frontier Science Initiative, Kanazawa University, 2WPI-Nano Life
Science Institute, Kanazawa University, 3Department of Immunology, Kanazawa University Graduate
School of Medical Sciences, 4Cell-Bionomics Research Unit, Institute for Frontier Science Initiative,
Kanazawa University)
高周波集束超音波スペクトロスコピーによる培養単一細胞への非侵襲局所力学刺激付与システ
ムの開発とヒト iPS 細胞の核の共振による超音波吸収帯
Development of ultrasound spectroscopic imaging system for applying highly controlled local
mechanical stimulation on cells
Natsumi Fujiwara, Takaki Matsumotio, Akira Nagakubo, Masahiro Kino-oka, Hirotsugu Ogi (Graduate
School of Engineering, University of Osaka)
神経分化における細胞内温度の貢献
Contribution of Intracellular Thermogenesis to Neural Differentiation
Shunsuke Chuma1,2, Hirotaka Okita2, Shingo Sotoma2, Kohki Okabe3,4, Yoshie Harada2,5 (1Dept. Biol.
Sci., Grad. Sch. Sci., Osaka Univ., 2IPR, Osaka Univ., 3Grad. Sch. Pharm. Sci., The Univ. Tokyo, 4JST
PRESTO, 5QIQB Osaka Univ.)
高速 AFM の更なる高速化に向けた Z-スキャナの共振制御装置
Resonance-controller of the Z-scanner for faster high-speed AFM
Kazuma Tatsumi1, Kenichi Umeda2, Toshio Ando2, Noriyuki Kodera2 (1Grad. Sch. Math. & Phys.,
Kanazawa Univ., 2WPI-NanoLSI, Kanazawa Univ.)
細胞内高速マッピングが細胞内の非伝導性の熱散逸の存在を明らかにする
High-speed Intracellular Temperature Mapping Reveals the Existence of Non-Conductive Heat
Dissipation within Cells
Masaharu Takarada1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Sch. of Pharm. Sci., The Univ ofTokyo, 2JST, PRESTO)
がん免疫において細胞傷害性指標となる液性因子分泌のライブセルイメージング
Live Cell Imaging of Liquid Factor Secretion as an Indicator of Cytotoxicity in Cancer Immunity
Yuto Kurisu1, Zhuohao Yang1, Koji Nagaoka2, Sotaro Kamimura3, Kazuhiro Kakimi2, Takashi Funatsu1,
Yoshitaka Shirasaki1 (1Grad. Sch. Pharmaceutical Sciences ., Univ.Tokyo, 2The Department of
Immunotherapeutics ., Univ. Tokyo. Hospital, 3Grad. Sch. Sciences ., Univ.Tokyo)– S166 –2Pos300*

2Pos301

2Pos302*2Pos303*

2Pos304

2Pos305*

2Pos306

2Pos307*

2Pos308

2Pos309

2Pos310*

2Pos3112Pos312*

高速原子間力顕微鏡のさらなる高速化を目指した超微小カンチレバーの開発
Development of ultra-small cantilever for faster high-speed atomic force microscopy
Noriki Katayama1, Kenichi Umeda2, Toshio Ando2, Noriyuki Kodera2 (1Grad. Sch. Math. & Phys.,
Kanazawa Univ., 2WPI-NanoLSI, Kanazawa Univ.)
ゴルジ体と小胞体の超解像顕微鏡による可視化解析
Observation and analysis of Golgi body and ER with super resolution microscopy
Kaoru Katoh1,2, Totai Mitsuyama2 (1Biomed Res Inst, AIST, 2AIRC, AIST)
高分解能ライトフィールド顕微鏡の開発によるシングルショット 3D イメージング
Development of high-resolution light-field microscopy for single-shot 3D volumetric imaging
Ryuki Imamura1, Shin Usuki2, Takuma Sugi1 (1Program of Biomedical Science, Graduate School ofIntegrated Sciences for Life, Hiroshima University, 2Research Institute of Electronics, Shizuoka
University)(2SBA-2) ヒト生細胞の局所クロマチン動態は細胞周期を通して一定である(2SBA-2) Single-nucleosome imaging reveals steady-state motion of interphase chromatin in
living human cells
Shiori Iida1,2, Soya Shinkai3, Yuji Itoh1, Sachiko Tamura1, Masato Kanemaki2,4, Shuichi Onami3,
Kazuhiro Maeshima1,2 (1Genome Dynamics Lab., Natl. Inst. of Genet., 2Dept. of Genet., Sch. of Life Sci.,
SOKENDAI, 3RIKEN BDR, 4Mol. Cell Eng. Lab., Natl. Inst. of Genet.)
High-speed atomic force microscopy mapping of Bacillus subtilis' mechanical properties
Christian Ganser1, Shigetaka Nishiguchi1, Takayuki Uchihashi1,2 (1ExCELLS, NINS, 2Grad. Sch. Sci.,
Nagoya Univ.)
高速 AFM 観察を用いた E6AP/E6/p53 複合体の構造ダイナミクスの解明
Structural dynamics of E6AP/E6/p53 complex revealed by high-speed AFM (HS-AFM)
Kazusa Takeda1, Ikumi Muro1, Hiroki Konno2 (1Grad. Sch. of Nat. Sci. & Technol., Kanazawa
University, 2WPI Nano Life Sci. Inst. (WPI-NanoLSI), Kanazawa Univ)
透過型電子顕微鏡の最大感度をもたらす新規ヒルベルト位相板
Novel Hilbert Phase Plates for Maximum Sensitivity in Transmision Electron Microscopy
Kuniaki Nagayama (N-EM Laboratories Inc.)
Dynamic unfolding of the laminin coiled-coil domain revealed by high-speed AFM
Lucky Akter1, Holger Flechsig1, Arin Marchesi1,2, Clemens Martin Franz1 (1WPI Nano Life Science
Institute, Graduate School of Frontier Science Initiative, Kanazawa University, Japan, 2Faculty of
Medicine and Surgery, Università Politechnica delle Marche, Italy)
脂肪細胞内脂質分布の TOF-SIMS 解析
Subcellular lipid analysis in a 3T3-L1 adipocyte by TOF-SIMS
Noritaka Masaki (National Institute of Genetics)
Development of genetically encodable tool for live-imaging and manipulation of endogenous
RNAs in living cells
Akira Takai1,2, Yasushi Okada1,2,3 (1Dept. Cell Biol., Grad. Sch. Med., Univ. Tokyo, 2BDR, RIKEN,
3Dept. Phys., Grad. Sch. Sci., Univ. Tokyo)
表面形状計測システムに向けた生体ナノポアプローブの特性
Characteristics of Biological Nanopore Probes as a Topological Imaging System
Shuta Nomi, Kan Shoji (Nagaoka University of Technology)
Raman spectral analysis of induced pluripotent stem cell during spontaneous differentiation
Hideaki Fujita1,2, Kensuke Sasaki2, Kazuhiro Sudo3, Yukio Nakamura3, Kuniya Abe3,
Yasuhiko Yoshida4, Takayuki Haruki4, Keiichi Koizumi5 (1Dept. Stem Cell Biol., RIRBM, Hiroshima
Univ., 2Lab. Comp. Biol., BDR, Riken, 3BRC, Riken, 4Faculty Sust. Design, Academic Assembly, Univ.
Toyama, 5RCPDS, Toyama Univ.)
真核細胞における翻訳活性変化の温度シグナリング機構の解明
Thermal Signaling Mechanisms of Translational Control in Eukaryotic Cells
Naoko Kamiya1, Kohki Okabe1,2, Takashi Funatsu1 (1Grad. Pharm. Sci., The Univ. of Tokyo,
2PRESTO,JST)– S167 –バイオエンジニアリング／Bioengineering
2Pos313

2Pos3142Pos315

2Pos316*

2Pos317

2Pos318

2Pos319*

2Pos320*

Structure mechanism for color tuning of red-colored chromoprotein, R-Velour
Le Zhai1,2, Ryosuke Nakashima2, Tomoki Matsuda1,2, Takeharu Nagai1,2 (1Graduate School of Frontier
Bioscience, Osaka University, Japan, 2SANKEN (The Institute of Scientific and Industrial Research),
Osaka University, Japan)
統合情報理論に基づいたスイッチング DNA 論理回路の構築
Construction of Switching DNA Logic Circuit based on Integrated Information Theory
Fumika Kambara1, Sotaro Takiguchi1, Hiroki Watanabe2, Masahiro Takinoue2, Ryuji Kawano1(1Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology /Japanese, 2Department of Life Science and Technology, Tokyo Institute of Technology / Japanese)(2SDA-5) ATP を検出可能な DNA ナノポアセンサの開発(2SDA-5) ATP-detectable DNA nanopore sensor
Hiromu Akai, Kan Shoji (Nagaoka University of Technology)
カスケード反応における酵素複合体形成の寄与
Contribution of three-enzyme complex via 3-way junction DNA to activity of the cascade reaction
Aoi Mameuda, Koki Kamiya (Grad. Sch. Sci. Tech. , Gunma Univ.)
様々な形状の DNA 検出のための β ストランド数変化した改変型 β バレルナノポアタンパク質の構築
Modified β-barrel nanopore-forming protein with changed the number of β-strands for detectionof various-shaped of DNA
Toshiyuki Tosaka, Koki Kamiya (Grad. Sch. Sci. Tech. Gunma Univ.)
塩基配列の設計による DNA 液滴の安定化
Stabilization of DNA droplets by designing base sequences
Kazuki Kobayashi1, Satoshi Takahashi2, Masahiro Takinoue1,2 (1Dept. Life Sci. Tech., Tokyo Tech,
2Dept. Computer Sci., Tokyo Tech)
液-液相分離に基づく分子検出ための DNA 液滴コンピュータ
Computational DNA droplets based on liquid-liquid phase separation for molecular detection
Jing Gong1, Nozomi Tsumura2, Yusuke Sato3, Masahiro Takinoue4 (1School of Life Science andTechnology, Univ. Tokyo Tech / Japanese, 2School of Engineering, Univ. Tokyo Tech / Japanese,
3Department of Intelligent and Control Systems, Univ. Kyushu Tech / Japanese, 4Department ofComputer Science, Univ. Tokyo Tech / Japanese)
油中水滴を活用した新規蛍光 RNA アプタマー創出法の開発
Feasibility study of the method for obtaining fluorogenic RNA aptamers using water-in-oil
microdroplets
Keisuke Ito, Ryo Iizuka, Sotaro Uemura (Dept. Biol. Sci., Grad. Sch. Sci., The Univ. Tokyo)

その他／Miscellaneous topics
2Pos321

有殻アメーバの頑健な卵型被殻構築過程の 4D イメージングおよび模型作成
4D Imaging and 3D modeling of the robust egg-shaped shell construction process of testate
amoebaMami Nomura1, Yukinori Nishigami2, Josephine Galipon3, Masatoshi Ichikawa4, Takuro Nakayama5,
Keisuke Ohta6, Kei-ichiro Nakamura6 (1Fac. Sci., Yamagata Univ., 2RIES, Hokkaido Univ., 3IAB, Keio
Univ., 4Dept. Phys., Kyoto Univ., 5CCS, Univ. Tsukuba, 6Sch. of Med., Kurume Univ.)– S168 –2Pos322*

2Pos323

2Pos324

2Pos325

ナノダイヤモンドを用いたアミロイド β 蛋白への新規標的治療法の検証
Verification of a new targeted therapy against amyloid-β using nanodiamonds
Miwa Shintani1,2, Shin-ichiro Yanagiya2, Hiroki Takanari2 (1Grad. Sch. opt., Uni. Tokushima / Japanese,
2Post-LED Photonics Inst., Uni Tokushima / Japanese)
関西におけるアカハライモリの警戒色の斑紋パターンの多様性
Diversity of warning coloration pattern in Kansai red-bellied newts
Sora Kazumi1, Rikiya Ogawa2 (1Osaka Prefecture Tondabayashi High School, 2Rikijuku Science School)
クサカゲロウの翅の反射防止性能
Anti-reflectivity in green lacewing wings
Yuro Katsurashima1, Leona Takahashi2, Kazunari Yoshida1 (1Grad. Sch. Sci. Eng., Univ. Yamagata,
2Grad. Sch. Sci. Eng., Univ. Aoyama Gakuin)
Enzymatically controlled micro-patterning of self-assembled nanoparticles by surface-boundATP
Ekta Shandilya, Subhabrata Maiti (Indian Institute of Science Education and Research (IISER) Mohali,
Punjab, India - 140306)
3 日目（9 月 30 日（金））／Day 3（Sep. 30 Fri.）

蛋白質：構造／Protein: Structure
3Pos001

3Pos002

3Pos003

3Pos004

3Pos005

3Pos006

3Pos007

全原子シミュレーションを用いた βαβ モチーフのレジスタシフトルールの解明
Explaining empirical rules of register shift of βαβ-motif by physical interactions
Senji Mishima, Hiroto Murata, George Chikenji (Dept. of App. Phys., Grad. Sch of Eng., Nagoya Univ.)
Structural Validation Properly Regulates Boost Potentials in the Biased Sampling of Proteins
Takunori Yasuda1, Rikuri Morita2, Yasuteru Shigeta2, Ryuhei Harada2 (1University of Tsukuba, Doctral
Program in Biology, 2University of Tsukuba, Center for Computational Sciences)
補酵素結合と二量体化による細菌の 3α‐ヒドロキシステロイド脱水素酵素（3αHSDs）の構造
揺らぎ変化に対する MD シミュレーション
MD simulation study of fluctuation changes of bacterial 3a-Hydroxysteroid Dehydrogenases(3aHSDs) by coenzyme binding and dimerization
Kahoru Amakawa1, Hiroki Suzuki2, Ayako Shiota2, Masayuki Oda2, Juha Lintuluoto3,
Masami Lintuluoto2 (1Fac. Life and Env., Univ. Kyoto Prefectural, 2Grad. Sch. Life and Env. Sci., Univ.
Kyoto Prefectural, 3Grad. Sch. Eng., Univ. Kyoto)
Structural determinants for distinguishing frequently and rarely occurring psi-loop motifs
Tomoki C. Terada, Takumi Nishina, George Chikenji (Dept of Appl. Phy., Grad. Sch. of Eng., Nagoya
Univ.)
蛋白質の荷電性残基が液-液相分離に及ぼす影響に関する粗視化分子動力学法による検討
A Coarse-Grained Molecular Dynamics Study to elucidate the effect of charged residues ofproteins on liquid-liquid phase separation
Yuji Kuriki1, Kota Kasahara2, Junichi Higo3, Takuya Takahashi2 (1Grad. Sch. Life Sci., Univ.
Ritsumeikan, 2Coll. Life. Sci., Univ. Ritsumeiakn, 3Grad. Sch. Simulation Studies. Univ. Hyogo)
3D Convolutional Neural Network を用いたタンパク質-ペプチドドッキングモデルの評価
Structure evaluation for protein-peptide docking models using 3D convolutional neuralnetworks
Hyeri Lim1, Shigeyuki Matsumoto1, Shuntaro Chiba2, Yuta Isaka2, Mayumi Kamada1, Yasushi Okuno1,2(1Grad. Sch. Med., Univ. Kyoto, 2R-CCS, RIKEN)
深層学習を用いたタンパク質ドメインの予測研究
A deep-learning model for the prediction of protein domains
Renta Sato1, Toru Ekimoto2, Takashi Yoshidome1 (1Dep. of Appl. Phys., Tohoku Univ., 2Grad. Sch. ofMed. Life Sci., Yokohama City Univ.)– S169 –3Pos008

3Pos009

3Pos010

3Pos011
3Pos012

3Pos013

3Pos014

3Pos015

3Pos016

3Pos017

3Pos018

Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
Kazuki Kato1, Sae Okazaki1, Soumya Kannan2, Han Altae-Tran2, Yukari Isayama1, Junichiro Ishikawa1,
Rhiannon K Macrae2, Tomohiro Nishizawa3, Kira S Makarova4, Eugene V Koonin4, Feng Zhang2,
Hiroshi Nishimasu1 (1RCAST.,Univ.Tokyo, 2MIT, 3Grad.Sch.Medical Life Science.,Univ.Yokohama City,
4NCBI)
Benchmark of force fields to characterize the short intrinsically disordered region of FUS-LC
domainMaud Chan-Yao-Chong, Justin Chan, Hidetoshi Kono (Molecular Modelling and Simulation (MMS)
Team, National Institutes for Quantum Science and Technology (QST))
Photon Factory における BioSAXS 測定システムの高度化
Upgrade of BioSAXS measurement system at the Photon Factory
Nobutaka Shimizu, Hideaki Takagi, Yasuko Nagatani, Takeharu Mori, Keiko Yatabe,
Masatsuyo Takahashi, Noriyuki Igarashi (PF, IMSS, KEK)
Structure determination of Ferritin at room temperature in microfluidic chips
Yusuke Kono, Leonard Chavas (Dept of Appl. Phys., Grod. Sch. of Eng., Nagoya Univ.)
分子動力学計算による FtsZ の構造変化機構の解析
Molecular dynamics simulations on the conformational stability of FtsZ with the different boundnucleotides
Taichi Takasawa1, Go Watanabe2,3, Yoshio Kodera2,4, Takashi Matsui2,4 (1Grad. Sch. Sci., Kitasato
Univ., 2Sch. Sci., Kitasato Univ., 3KISTEC, 4Cent. Disease Proteomics)(2SEA-7) Optineurin の E50K 緑内障変異はオリゴマー粒径を増大させる(2SEA-7) The E50K mutation of optineurin increases the oligomer size
Rintaro Kawamura1, Soya Uetsuki1, Takehito Tanzawa2, Takayuki Kato2, Masataka Kinjo3,
Akira Kitamura3 (1Grad. Sci. Life Sci., Hokkaido Univ., 2Inst., for Proteins Res., Osaka Univ., 3Fac. Adv.
Life sci., Hokkaido Univ.)
鶏卵白リゾチームの D/H コントラスト法を利用した中性子結晶解析
Neutron crystallography of hen-egg white lysozyme using D/H contrast technique
Toshiyuki Chatake1, Ichiro Tanaka2, Katsuhiro Kusaka3, Satoru Fujiwara4 (1Inst. Integ. Rad. Nucl. Sci.,
Kyoto Univ., 2Grad. Sci. Eng., Ibaraki Univ., 3Front. Res. Cent. App. Atom. Sci., Ibaraki Univ., 4Inst.
Quantum Life Science, QST)
多分散溶液中の生体高分子の構造解析のための超遠心分析と小角散乱による統合アプローチ
Integrated approach to biomacromolecular structure in polydisperse solution with analyticalultracentrifugation and small-angle scattering
Ken Morishima, Rintaro Inoue, Aya Okuda, Nobuhiro Sato, Masahiro Shimizu, Yasuhiro Yunoki,
Reiko Urade, Masaaki Sugiyama (Institute for Integrated Radiation and Nuclear Science, Kyoto
University)
クライオ電子顕微鏡による高精度構造解析
High-precision structural analysis by cryo-electron microscopy
Tasuku Hamaguchi1, Keisuke Kawakami2, Saori Maki-Yonekura2, Koji Yonekura1,2 (1IMRAM, Tohoku
Univ., 2RIKEN SPring-8 Center)
Preparation of phosphorylated FROUNT protein, a regulator of chemokine receptors, forstructural and functional analyses
Keisuke Uchida1, Sosuke Yoshinaga1, Takafumi Sato1, Mitsuhiro Takeda1, Yuya Terashima2,3,
Etsuko Toda2,3,4, Kouji Matsushima2,3, Hiroaki Terasawa1 (1Fac. Life Sci., Kumamoto Univ., 2Grad. Sch.
Med., Univ. Tokyo, 3RIBS, Tokyo Univ. Sci., 4Nippon Med. Sch.)
Computational analysis on the effects of active-site reduction on structures and dynamics ofplant-type ferredoxin
Tomoki Nakayoshi1, Yusuke Ohnishi2, Hideaki Tanaka2, Genji Kurisu2, Yu Takano1 (1Grad. Sch. Inf.
Sci., Hiroshima City Univ., 2Inst. Protein Res., Osaka Univ.)– S170 –3Pos019

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3Pos023

Efficient Conformational Sampling with an Adaptive Coarse-Grained Elastic Network Modelusing Dynamic Cross-Correlation Coefficient
Ryo Kanada1, Kei Terayama2, Atsushi Tokuhisa1, Shigeyuki Matsumoto3, Yasushi Okuno1,3 (1RCCS,
RIKEN, 2Grad. Sch. Medical Life Sci., Yokohama City Univ., 3Grad. Sch. Medicine, Kyoto Univ.)
Structural basis of actin-microtubule crosstalk mediated by GAS2
Jiancheng An, Tsukasa Makino, Masahide Kikkawa (The University of Tokyo)
Cryo-EM structure of an osmotically sensitive Ca2+ ion channel
Honoka Hosoki, Tatsuya Hagino, Kanae Demura, Wataru Shihoya, Tsukasa Kusakizako, Osamu Nureki(Grad.Sch.Sci.,Univ.Tokyo)
結晶構造から明らかになったシゾロドプシンの内向きプロトン輸送機構
Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping
Wataru Shihoya1, Akimitsu Higuchi1, Masae Konno2, Tatsuya Ikuta1, Hideki Kandori3, Keiichi Inoue2,
Osamu Nureki1 (1Grad. Sch. Sci., The Univ of TOkyo, 2ISSP, The Univ of TOkyo, 3Life Sci. Appl. Chem.,
Nagoya Inst. Tech.)
タンパク質中性子回折実験における水素高感度検出のための技術開発
Technological development for high-sensitivity detection of hydrogen in protein neutron
diffraction experiments
Ichiro Tanaka1,2, Hideki Yamauchi1, Yohei Noda1,2, Tomoki Maeda2, Satoshi Koizumi1,2 (1Grad. Sch.
Sci. Eng., Ibaraki Univ., 2Frontier Res. Center Appl. Atomic Sci., Ibaraki Univ.)

蛋白質：構造機能相関／Protein: Structure & Function
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3Pos027

FAP47, HYDIN, and CPC1 in the central pair apparatus of Chlamydomonas
Yuma Tani1, Haruaki Yanagisawa1, Toshiki Yagi2, Masahide Kikkawa1 (1Grad. Sch. Med., Univ. Tokyo,
2Life Sci., Pref. Univ. Hiroshima)
昆虫由来不凍タンパク質は哺乳動物細胞を－5℃でも生存可能にする
Insect-derived antifreeze protein allows mammalian cells to survive at －5°C
Akari Yamauchi1, Hidemasa Kondo2,3, Tatsuya Arai4, Sakae Tsuda2,4,5 (1Inst. Low Temp. Sci., Univ.
Hokkaido, 2Grad. Sch. Life Sci., Univ. Hokkaido, 3Hokkaido Inst., AIST , 4Grad. Sch. Frontier Sci.,
Univ. Tokyo, 5Tokyo Inst., AIST )Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-ActivatedProtein Kinase (MAPK) at the Allosteric Site
Utid Suriya1, Panupong Mahalapbutr2, Thanyada Rungrotmongkol3,4 (1Program in Biotechnology,
Faculty of Science, Chulalongkorn University, Bangkok, Thailand, 2Department of Biochemistry, andCenter for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khan Kaen 40002,
Thailand, 3Structural and Computational Biology Research Unit, Department of Biochemistry,
Chulalongkorn University, Bangkok, Thailand, 4Ph.D. Program in Bioinformatics and Computational
Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand)
Designed darunavir derivatives against HIV-1 protease: A computational study
Hathaichanok Chuntakaruk1, Tanatorn Khotavivattana2, Chanat Aonbangkhen2,
Phornphimon Maitarad3, Thanyada Rungrotmongkol1,4, Supot Hannongbua1,5 (1Program in
Bioinformatics and Computational Biology, Grad. Sch., Chulalongkorn Univ., Bangkok 10330, Thailand,
2Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science,
Chulalongkorn Univ., Bangkok 10330, Thailand, 3Research Center of Nano Science and Technology,
Shanghai Univ., NO 99, Shangda Road, PO Box 111, Baoshan district, Shanghai, 200444 People’s
Republic of China, 4Biocatalyst and Environmental Biotechnology Research Unit, Department ofBiochemistry, Faculty of Science, Chulalongkorn Univ., Bangkok 10330, Thailand, 5Center of Excellencein Computational Chemistry (CECC), Department of Chemistry, Faculty of Science, Chulalongkorn
Univ., Bangkok 10330, Thailand)– S171 –3Pos028

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3Pos034

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3Pos036

Structural effects of spike variants that reshaped the pandemic
Hisham Dokainish1,2, Yuji Sugita1,3,4 (1Theoretical Molecular Science Laboratory, RIKEN Cluster for
Pioneering Research, Wako, Japan, 2Faculty of Pharmaceutical Sciences, Hokkaido University,
3Computational Biophysics Research Team, RIKEN Center for Computational Science, Kobe, Japan,
4Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research,
Kobe, Japan)
コレラ菌走化性受容体 Mlp3 のリガンド認識機構
Ligand recognition mechanism of Mlp3, a chemoreceptor of Vibrio cholerae
Yuka Ueda1, Yuzuki Yabunaka1, Norihiro Takekawa1, So-ichiro Nishiyama2, Hirotaka Tajima3,
Ikuro Kawagishi3, Katsumi Imada1 (1Dept. Macromol. Sci., Grad. Sch. Sci., Osaka Univ., 2Dept. Appl
Life Sci, Niigata Univ of Pharm and Appl Life Sci., 3Dept. Front Biosci., Hosei Univ.)
HIV 逆転写酵素の薬剤耐性変異に対する動的残基間相互作用ネットワーク解析
Dynamic Residue Interaction Network Analysis of HIV-1 Reverse Transcriptase for Drug
Resistance Mutations
Ryuki Hashimoto, Norihumi Yamamoto (Chiba Tech)
HIV-1 の Nelfinavir 耐性プロテアーゼ D30N/L90M 変異体に対する動的残基間相互作用ネットワー
ク解析
Dynamic Residue Interaction Network Analysis of the Protease D30N/L90M Mutant Conferring
Nelfinavir Resistance in HIV-1
Ryoga Miyawaki, Norihumi Yamamoto (Chiba Tech)
イオタ毒素 Ia-GFP キメラのタンパク質膜透過の確認と構造解析
Confirmation of protein membrane translocation and structural analysis of Iota toxin Ia-GFP
chimeraShun Tomoda, Tomohito Yamada, Hideaki Tsuge (Graduate School of Life Science, Kyoto Sangyo
University)
酸化還元感受性の鉄硫黄クラスターを利用する tRNA 硫黄修飾酵素の反応機構
The reaction mechanism of tRNA sulfur modification enzymes using redox-sensitive iron-sulfur
clusters
Masato Ishizaka1, Minghao Chen1,2, Shun Narai1, Yoshikazu Tanaka2,3, Masaki Horitani4,5, Min Yao2
(1Grad. Sch. Life Sci., Hokkaido Univ., 2Fac. Adv. Life Sci., Hokkaido Univ., 3Grad. Sch. Life Sci., Tohoku
Univ., 4Fac. Agri., Saga Univ., 5United Grad. Sch. Agri. Sci., Kagoshima Univ.)
A new enzyme from tardigrades which consists of ferritin-like and IgG-like domains
Subaru Kato, Yota Fukuda, Tsuyoshi Inoue (Graduate School of Pharmaceutical Sciences, Osaka
University)
生物発光タンパク質イクオリンのアロステリックな発光反応制御機構についての理論的研究
Theoretical study on allosteric control mechanism of a luminescent reaction of bioluminescentprotein aequorin
Tomohiro Ando, Shigehiko Hayashi (Grad. Sch. Sci., Kyoto Univ.)
Structural dynamics and kinase inhibitory activity of tyrosine kinase inhibitors against wild-type
and mutant forms of EGFR
Rungrotmongkol Thanyada1,5, Todsaporn Duangjai1, Mahalapbutr Panupong2,
P. Poo-arporn Rungtiva3, Choowongkomon Kiattawee4 (1Center of Excellence in Biocatalyst andSustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University,
Bangkok 10330, Thailand, 2Department of Biochemistry, and Center for Translational Medicine, Facultyof Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, 3Biological Engineering Program,
Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, Thailand,
4Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand,
5Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University,
Bangkok 10330, Thailand)– S172 –3Pos037

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RNA-seq 解析によるセイヨウイトスギの新規アレルゲン候補の探索
Searching for new allergen candidates in European cypress by RNA-seq analysis
Tomona Iizuka1, Hélène Sénéchal2, Pascal Poncet3, Tomoyasu Aizawa1 (1Grad. Sch. Life Sci., Hokkaido
Univ., 2Allergy & Environment, Armand Trousseau Children Hospital, Paris, France, 3Immunology
Department, Institute Pasteur, Paris, France)
分子動力学法による自己集合性ペプチドの配列最適化
Sequence optimization of self-assembly peptides by using MD simulations
Koya Sato1, Kota Kasahara2, Hiroshi Imamura2, Takuya Takahashi2 (1Grad. Sch. Life Sci., Univ.
Ritsumeikan, 2Coll. Life. Sci., Univ. Ritsumeikan)
緑色蛍光タンパク質のループ領域の静電ポテンシャルに影響を及ぼす部位特異的アミノ酸置換と分子構造および発光特性の相関
Correlation of amino acid substitutions affecting the electrostatic potential of loop region withstructure and luminescence properties
Kaori Chiba, Kokomi Takanashi (Indust. Eng. Natl. Inst. Tech, Ibaraki Coll. Japan)
分子動力学計算によるダイナミンの誘電アロステリー解析
Dielectric allostery of dynamin studied by molecular dynamics simulation
Masataka Yaguchi1, Jun Ohnuki2, Mitsunori Takano1 (1Dept. of Pure & Appl. Phys., Grad. Scl. Adv. Sci.
& Eng., Waseda Univ., 2Inst. for Mol. Sci.)
HIV-1 Vif タンパク質によるヒト抗ウイルス因子 APOBEC3 タンパク質のマルチファセットな無力化: ユビキチン化と脱アミノ化阻害
HIV-1 Vif drived multifaceted neutralization against human APOBEC family proteins:ubiquitination/degradation and deamination inhibition
Keisuke Kamba1, Li Wan1,2, Kentaro Tozawa1,2, Ryo Iwaoka1,2, Satoru Unzai3, Ryo Morishita4,
Akifumi Takaori-Kondo5, Takashi Nagata1,2, Masato Katahira1,2 (1Inst. of Adv. Energy, Kyoto Univ.,
2Grad. Sch. Energy Sci., Kyoto Univ., 3Frontier Bioscience, Hosei Univ., 4CellFree Sciences Co.,Ltd.,
5Grad. Sch. Med., Kyoto Univ.)
タンパク質構造の熱揺らぎと進化しやすさは相関している
Dynamics-Evolution Correspondence in Protein Structures
Qianyuan Tang1,2, Kunihiko Kaneko1 (1Center for Complex Systems Biology, Universal Biology
Institute, University of Tokyo, 2Lab for Neural Computation and Adaptation, RIKEN Center for Brain
Science)
シアン化物結合シトクロム酸化酵素の結晶構造から示唆される、金属中心の酸化状態変化による活性制御機構
Crystallographic cyanide-probing of cytochrome oxidase provides insights into its activity
regulation by the redox change of metal sites
Atsuhiro Shimada1, Kazumasa Muramoto2, Kyoko Shinzawa-Itoh2, Tomitake Tsukihara3,
Shinya Yoshikawa2 (1Dept. Appl. Life Sci., Fac. Appl. Biol. Sci., Gifu Univ., 2Grad. Sch. Sci., Univ.
Hyogo, 3Inst. Protein Res., Osaka Univ.)
アクチンフィラメントの張力依存的な構造変化の解析
Analysis of the tension dependent structural changes of actin filament
Fumito Matsuzaki, Tao Q.P. Noguchi (National Institute of Technology, Miyakonojo College)
Kai 時計システムにおける分子の統合運動
Orchestration of proteins in a Kai clock system
Masaaki Sugiyama1, Ken Morishima1, Yasuhiro Yunoki1, Rinatro Inoue1, Nobuhiro Sato1,
Hirokazu Yagi2, Koichi Kato3 (1KURNS, 2Grad. Sch. Phar., Nagoya City Univ., 3ExCELLS)– S173 –蛋白質：物性（安定性 折れたたみなど）／Protein: Property
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高分子クラウディング環境下での蛋白質溶解度の進化
Evolution of protein solubility in macromolecular crowding
Yasuhiro Isogai1, Hiroshi Imamura2, Tomonari Sumi3, Tsuyoshi Shirai4 (1Dept. PharmaceuticalEngineering, Toyama Prefectural Univ., 2Dept. Bio-Science, Nagahama Inst. Bio-Science andTechnology, 3Research Inst. Interdisciplinary Science, Okayama University, 4Dept. Computer Bioscience,
Nagahama Inst. Bio-Science and Technology)
Dispersion Effect of Molecular Crowding on Ligand-Protein Surface Binding Sites of Escherichia
coli RNase HI
Chikashi Ota2, Hikari Suzuki1, Shun-ichi Tanaka1, Kazufumi Takano1 (1Kyoto Prefectural University,
2Ritsumeikan University)
線維形成前駆状態 β2 ミクログロブリンの残余構造がアミロイド線維のモルフォロジーに与える
影響
The residual structure of acid-denatured β2-microglobulin is relevant to an ordered fibril
morphology
Ryosuke Tomiyama1, Masatomo So2, Yohei Miyanoiri3, Kazumasa Sakurai1,4 (1Graduate School of
Biology-Oriented Science and Technology, Kindai University, 2Astbury Centre for Structural Molecular
Biology, University of Leeds, 3Institute for Protein Research, Osaka Univeristy, 4Institute of Advanced
Technology, Kindai University)
透析アミロイドーシスの発症機構における分子夾雑環境の役割
Role of macromolecular crowding in the onset mechanism of dialysis-related amyloidosis
Kichitaro Nakajima1, Keiichi Yamaguchi1, Suguru Yamamoto2, Yuji Goto1 (1Global Center for Med.
Eng. Info., Osaka Univ., 2Grad. Sch. Med. Dent. Sci., Niigata Univ.)
異種フィブロイン混合系におけるナノファイバー/前駆体形成評価
Evaluation of nanofiber/precursor formation in heterogeneous fibroin mixtures
Haruya Kajimoto1, Kento Yonezawa2, Kok Sim Chan1, Takehiro Sato3, Yoichi Yamazaki1,
Sachiko Toma-Fukai1, Hironari Kamikubo1,2 (1NAIST, MS, 2NAIST, CDG, 3Spiber Inc.)
アラニンスキャン変異解析による c-Myb–KIX 間相互作用に重要なアミノ酸残基の同定
Identifying key residues of c-Myb–KIX interaction by alanine scanning mutagenesis
Shunji Suetaka1, Yuuki Hayashi1,2, Munehito Arai1,3 (1Dept. Life Sci., Univ. Tokyo, 2Environmental
Science Center, Univ. Tokyo, 3Dept. Phys., Univ. Tokyo)
高温条件下における耐熱化デンプンブランチングエンザイムの MD シミュレーションによる構造解析
Molecular Dynamics Simulation of Heat-Resistant Starch Branching Enzyme under High
Temperature Conditions
Kosuke Nariyama1, Yoh Noguchi1,3, Motokuni Nakajima1, Hironao Yamada2,3, Ryota Morikawa1,
Masako Takasu1, Shoko Fujiwara1 (1Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2Sch. of
Pharm., Tokyo Univ. of Pharm. and Life Sci., 3The Institute of Statistical Mathematics)
分子シミュレーションにおける高次項を用いた補間による自由エネルギー地形の推定
Estimation of Free-Energy Landscape for Molecular Simulations by Interpolation with HigherOrder Terms
Shohei Toyama1,2, Yuji Higuchi3, Hiroshi Noguchi1 (1ISSP., Univ. Tokyo, 2Dept. Phys., Univ. Tokyo,
3RIIT., Univ. Kyushu)
アミロイド β タンパク質の分子構造動態に D-アスパラギン酸が与える影響
Effect of D-Aspartic Acid on the Conformational Dynamics of Amyloid-β1-42 Protein
Yu Fukuda1, Takeru Kameda1, Shin-ichi Tate3, Yuichi Togashi1,2 (1Coll. Life Sci., Ritsumeikan Univ.,
2Riken BDR, 3Grad. Sch. Integ. Sci. Life, Hiroshima Univ.)– S174 –3Pos055

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タンパク質複合体における複数残基間相互作用の解析
Analysis of multiple residue interactions in protein complexes
Masaki Koyama, George Chikenji (Dept. of Appl. Phys., Grad. Sch. of Eng., Nagoya Univ.)
蛍光タンパク質イクオリンとカルシウムの結合に関する熱力学的解析
Thermodynamic analysis of the calcium binding with photoluminescence protein; aequorin
Urara Kuroki1, Toshiya Funahashi2, Yusuke Onishi3, Toru Nakatsu3, Tetsunari Kimura1 (1Grad. Sch. ofSci., Kobe Univ., 2Grad. Sch. of Pharm. Sci., Kyoto Univ., 3Sch. of Pharm. Sci., Univ. Wakayama Med.)CHARMM C36m 力場のタンパク質-水相互作用の強化によるタンパク質の水溶液環境及び混雑環境における拡散性及び熱力学的特性の改善
Improved diffusive and thermodynamic properties of proteins with modified interactions between
water and protein in CHARMM c36m
Daiki Matsubara1, Kento Kasahara2, Hisham Dokainish3, Hiraku Oshima1, Yuji Sugita1,3,4 (1Kobe Inst.,
RIKEN, 2Grad. Sch. Eng., Univ. Osaka, 3Wako Inst., RIKEN, 4Kobe Inst., RIKEN)
Structural Characteristics Investigation of Hero Peptides Using All-atom Molecular Dynamics
Simulations
Haeri Im1, Ai Niitsu1, Cheng Tan2, Yuji Sugita1,2,3 (1Theoretical Molecular Science Laboratory, RIKEN
Cluster for Pioneering Research, Wako, Japan, 2Computational Biophysics Research Team, RIKEN
Center for Computational Science, Kobe, Japan, 3Laboratory for Biomolecular Function Simulation,
RIKEN Center for Biosystems Dynamics Research, Kobe, Japan)
乾燥耐性生物クマムシのミトコンドリア局在性熱可溶性タンパク質 MAHS ・LEAM における乾燥誘導性 LLPS
Dehydration inducible LLPS of the mitochondria localized heat-soluble protein MAHS & LEAM
of an anhydrobiotic tardigrade
Sae Tanaka1,2, Kazuharu Arakawa1,2 (1National Institutes of Natural Sciences, Exploratory ResearchCenter on Life and Living Systems, Section for Exploration of Life in Extreme Environments, 2Institute forAdvanced Biosciences, Keio University)
ベイズ学習による格子タンパク質模型のデザイン
Lattice protein design using Bayesian learning
Tomoei Takahashi1, George Chikenji2, Kei Tokita1 (1Grad. Sch. Inf. Nagoya Univ., 2Grad. Sch. Eng.
Nagoya Univ.)
がん抑制タンパク質 p53 のアモルファス凝集体・アミロイド凝集体への新たなる知見
New insights into morphous & amyloid aggregates of the tumor suppressor p53
Emi Hibino1, Reiji Hijikata2, Takeshi Tenno1,3, Hidekazu Hiroaki1,3 (1Grad. Sch. Pharm. Sci., Nagoya
Univ., 2Sch. Sci., Nagoya Univ., 3BeCellBar)
細胞質中のヌクレオチド三リン酸によって改変される生体高分子の相互作用と安定性
Stability and interaction of macromolecules altered by nucleoside triphosphates in cytoplasm
Isseki Yu1, Ryuto Yamazaki1, Michael Feig2, Yuji Sugita3 (1Maebashi Institute of Technology
Information Systems Program, 2Michigan State University Department of Biochemistry and Molecular
Biology, 3Riken Theoretical Molecular Science Laboratory)

蛋白質：機能（反応機構 生物活性など）／Protein: Function
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自由エネルギー解析によるトリプトファン合成酵素におけるアロステリックなトリプトファン
合成機構の解明
Allosteric regulation mechanism of tryptophan synthesis in tryptophan synthase by free energy
analysisShingo Ito, Kiyoshi Yagi, Yuji Sugita (Theor. Mol. Sci. Lab., CPR, RIKEN)
Cryptdin-4, a mouse α-defensin, with multiple antibacterial mechanisms regulated by its redox
structure and environmental conditions
Yi Wang, Yuchi Song, Rina Hiramine, Tomoyasu Aizawa (Grad. Sch. Life Sci., Hokkaido Univ.)– S175 –3Pos065

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Insights into the allosteric modulation of catalysis via a single surface mutation on a flexible loop
in dihydrofolate reductase
Sandhya Premnath Tiwari, Shinichi Tate (Grad. Sch. of Integrated Sciences for Life, Hiroshima
University)
大腸菌フェリチンの鉄酸化とミネラル化に与えるリン酸の効果
Effect of phosphate on the iron oxidation and mineralization in Escherichia coli ferritin
Takumi Kuwata, Kazuo Fujiwara, Masamichi Ikeguchi (Dept. of Biosci., Grad. Sch. of Sci and Eng.,
Soka Univ)
テロメアブーケ形成における Mps3、Rpf2-Rrs1、Ebp2-Brx1 間の結合関係
Binding relationships among Mps3, Rpf2-Rrs1 and Ebp2-Brx1 in telomere bouquet formation
Hao Li1, Takuma Eguchi1, Isao Tanaka1,2, Toyoyuki Ose1,2, Min Yao1,2 (1Graduate School of Life
Science, Hokkaido University, 2Faculty of Advanced Life Science, Hokkaido University)
IL-6 刺激下における非リン酸化型 STAT3 動態の解析
Analyses of the unphosphorylated STAT3 dynamics in the IL-6 activated pathway
Rin Tanaka1,2, Michio Hiroshima2, Masahiro Ueda1,2 (1Grad. Sch. Sci., Univ. Osaka, 2Osaka Inst.,
Riken)
A simple coarse-grained model for ADP binding to HSP90
Kazutomo Kawaguchi, Hidemi Nagao (Inst. Sci. Eng., Kanazawa University)
分子動力学に基づく混雑環境がタンパク質-リガンド結合に与える影響の速度論的解析
Kinetic analysis of the crowder effects on protein-ligand processes based on the molecular
dynamics
Kento Kasahara (Grad. Sch. Engr. Sci., Osaka Univ.)
ジアゾ化酵素 Fur5 のジアゾ化反応機構の計算化学的解析
Computational analysis of the diazotization reaction mechanism of diazo-forming enzyme Fur5
Shota Kaneko, Yoshitaka Moriwaki, Tomohiro Noguchi, Tomohisa Kuzuyama, Tohru Terada,
Kentaro Shimizu (Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo)
二重スピンラベル-ESR 分光法による ABC トランスポーターの膜貫通ドメインのコンフォメー
ション変化
Conformational changes in transmembrane domain of ABC transporter revealed by double spinlabel-ESR spectroscopy
Ayaka Naka1, Yasuhiro Kobori1,2, Motonari Tsubaki1, Yoshitsugu Shiro3, Hiroshi Sugimoto3,4,
Tetsunari Kimura1 (1Grad. Sch. Sci., Kobe Univ., 2Mol. Photo. Res. Cent., Kobe Univ., 3Grad. Sch. Sci.,
Univ. Hyogo, 4SPring-8, RIKEN)
時間分解分光測定を用いた ABC トランスポーター BhuUV-T におけるヘム輸送機構の解析
Tire-resolved spectroscopic analysis of allocrite transport mechanism in heme ABCtransporter; BhuUV-T
Akiho Hara1, Yoshitsugu Shiro2, Hiroshi Sugimoto2,3, Tetsunari Kimura1 (1Grad. Sch. of Sci., Kobe
Univ., 2Grad. Sch. Sci., Univ. of Hyogo, 3SPring-8, RIKEN)

蛋白質：計測・解析の方法論／Protein: Measurement & Analysis
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Refinement of MD-derived conformational ensemble by referring to experimental SANXS data
in framework of Bayesian statistics
Tomotaka Oroguchi1,2 (1Faclt. Sci. Tech., Keio Univ., 2RIKEN SPring-8 Center)– S176 –3Pos075

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蛍光相関分光法を用いたリボソーム-新生鎖複合体と相互作用する大腸菌 Trigger Factor シャペ
ロンの動態観察
Application of fluorescence correlation spectroscopy to investigate dynamics of a ribosomeassociated trigger factor chaperone in E. coli.
Tatsuya Niwa1,2, Koki Nakazawa1, Kensuke Hoshi1, Hisashi Tadakuma3, Koichi Ito4, Hideki Taguchi1,2(1Dept.of Life Science and Technology, Tokyo Tech., 2Cell Biology Center, IIR, Tokyo Tech., 3Sch. of Life
Science and Technology & Gene Editing Center, ShanghaiTech University, 4Dept. of Computational
Biology & Medical Sciences, Grad. Sch. of Frontier Sciences, Tokyo University)
BLI 法を用いた変性 LDL と LDL 関連受容体との結合特性
Binding properties of LDL to recombinant receptors were investigated by biolayer interfere layer
methodSeiji Takeda1, Nozomu Sato1, Ao Hamamuki1, Kanako Usirogata2, Taichi Takasuka2 (1Dept. Pharm.,
Hokkaido Univ. of Sci., 2Grad. Sch. GFR., Hokkaido University)
一定力下での非平衡分子動力学シミュレーションの再検討
Non-equilibrium molecular dynamics simulation under constant force revisited
Shinji Iida, Tomoshi Kameda (National Institute of Advanced Industrial Science and Technology)
量子ビームを利用した膜タンパク質分子内ダイナミクスの直接検出
Direct detection of intramolecular dynamics of membrane proteins using X-ray based analysis
techniques
Kazuhiro Mio1,2, Tatsunari Ohkubo1,2, Shoko Fujimura1,3, Tatsuya Arai3, Hiroshi Sekiguchi4,
Yuji C. Sasaki1,3,4 (1Operand OIL, AIST, 2Grad. Sch. Med. Sci., Yokohama CU, 3Grad. Sch. of Front. Sci.,
The Univ of Tokyo, 4JASRI)
ノイズのある原子間力顕微鏡像からの探針形状推定法の開発
Development of blind tip reconstruction method for noisy atomic force microscopy images
Ryuhei Oshima (Grad. Sch. Sci. Eng., Saitama Univ.)
木探索分子動力学法による Interleukin-2-inducible T-cell kinase 活性化経路の探索
Activation Pathway of Interleukin-2-inducible T-cell kinase Explored by Tree-Search Molecular
Dynamics
Yukina Nakai1, Toru Ekimoto1, Tsutomu Yamane2, Naoki Ogawa1, Masao Inoue1, Kei Terayama1,
Mitsunori Ikeguchi1,2 (1Dept. of Med. Life Sci., Yokohama City Univ., 2R-CCS, Riken)
微分可能な多状態ベネット受容比法を用いたシミュレーションモデルパラメータの効率的なチューニング
Efficient parameter tuning of simulation models by differentiable multistate Bennett’s
acceptance ratio method
Haruto Uchino, Yasuhiro Matsunaga (Grad. Sch. Sci. Eng., Saitama Univ.)
深層学習によるグリッドベースの水和自由エネルギー計算
A deep-learning model for Grid-based Solvation Free Energy
Yusaku Fukushima, Takashi Yoshidome (Dep. of Appl. Phys., Tohoku Univ.)
生体分子による液-液相分離とその環境要因を予測する機械学習モデルの開発
Development of machine learning models to predict liquid-liquid phase separation of
biomolecules and its environmental factors
Kayin Chin, Shoichi Ishida, Kei Terayama (Grad. Sch. Med. Life Sci., Yokohama City Univ.)
自由エネルギー摂動法を用いた VHH 抗体の等電点の制御
In silico control of isoelectric point of VHH using free energy perturbation method
Soichiro Oda, Yasuhiro Matsunaga (Grad. Sch. Sci. Eng., Saitama Univ.)
X 線構造解析とラマン分光によるテトラペプチド結晶中の水素結合ネットワークの解析
Hydrogen network in a tetrapeptide crystal characterized by X-ray diffraction and Raman
spectroscopy
Kazunori Motai1, Masaki Kawano2, Yuji Mochizuki3,4, Takehiko Mori1, Yuhei Hayamizu1 (1Departmentof Materials Science and Engineering, Tokyo Tech, 2Department of Chemistry, School of Science, Tokyo
Tech, 3Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo
University, 4Institute of Industrial Science,The University of Tokyo)– S177 –蛋白質：蛋白質工学／進化工学／Protein: Engineering
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気軽に試せる計算機タンパク質デザインに向けて
Towards easy-to-try computational protein design
Naoya Kobayashi, Shun Hirota (NAIST, Mat. Sci.)
phi29 ファージ DNA 複製を用いた人工 DNA ゲノム進化系の構築
Development of an artificial DNA genome evolution platform using the phi29 DNA replication
Taro Furubayashi1,2, Yoshihiro Minagawa1, Hiroyuki Noji1 (1Grad. Sch. Eng., Univ. Tokyo, 2JSPS)
RNA メチル基転移酵素の配列特異性および補酵素選択性を改変する進化分子工学的手法の開発
Development of a directed evolution method for changing sequence specificity and cofactor
selectivity of RNA methyltransferases
Yoshiki Ochiai, Paola Laurino (Protein Engineering and Evolution Unit, OIST)
ヘリックス-ループ-ヘリックスペプチドを分子基盤とする細胞内タンパク質間相互作用阻害剤の
分子設計
A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold to Design Inhibitors against
Iintracellular Protein-Protein Interactions
Daisuke Fujiwara, Masataka Michigami, Ikuhiko Nakase, Ikuo Fujii (Grad. Sch. Sci., Osaka
Metropolitan Univ.)
cDNA display 法により取得されたペプチドアプタマーの迅速かつ最適なダイマー化への新しいコンビナトリアル手法の開発
High-throughput identification of bivalent peptide aptamers selected by cDNA display with a
newly combinatorial approach
Taro Noguchi1, Kanako Nakao1, Shigefumi Kumachi1, Masayuki Tsuchiya1, Naoto Nemoto1,2 (1Epsilon
Molecular Engineering, Inc., 2Grad. Sch. Sci. & Eng., Saitama Univ.)
Model screening of a peptide by individual evaluation and separation using a combination of
FACS and peptide ligase display (PL display)
Shingo Ueno, Fumi Toshioka, Takanori Ichiki (iCONM, Kawasaki Inst. Industry. Promo.)
CRISPR-Cas ファミリータンパク質のデザインと標的探索の解明
Engineering and elucidation of target search by CRISPR-Cas family proteins
Trishit Banerjee1,2, Hiroto Takahashi2, Kiyoto Kamagata1,2 (1Grad.Sch.Sci., Tohoku Uni., 2IMRAM,
Tohoku Uni.)(1SEP-5) Control of small G-protein Ras using calmodulin-based ionochromic molecular device
Yassine Sabek, Nobuyuki Nishibe, Kazunori Kondo, Shinsaku Maruta (Graduate school of science andengineering , department of biosciences , soka university, Hachioji TOKYO)
ヒト・ノイラミニダーゼの構造解析に向けたハイブリッドモデル作成
The investigation of hybrid models for the structure determination of human Neuraminidases
Takeru Nakajima (Dept. Appl. Phys., Nagoya Univ. / Japanese)

膜蛋白質／Membrane proteins
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Deciphering the signal transmission of activation mechanism for chemokine CXCL12-boundreceptor CXCR4 in complex with Gi-protein
Ting-Yu Hu1, Hao-Jen Hsu1,2, Chun-Chun Chang3,4 (1Department of Life Sciences, College of Medicine,
Tzu chi University, 2Department of Biochemistry, School of Medicine, Tzu Chi University, 3Departmentof Laboratory Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 4Departmentof Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University)– S178 –3Pos096

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GPCR の相互作用ネットワーク解析
Interaction Network Analysis of GPCRs
Yusuke Higaki1, Wataru Nemoto2, Yoshihiro Yamanishi3, Hiroyuki Toh1 (1Dept. of Bio. Med. Sci., Grad.
Sch. of Sci., Univ. of Kangaku, 2Dept. of Life. Sci. Eng., Grad. Sch. of Sci., Univ. of Touden, 3Dept. of
Biosci. Bioinfo., Grad. Sch. of Com. Sci., Univ. of Kyukou)
全反射赤外分光法による GPCR のリガンド認識機構研究
ATR-FTIR study of ligand recognition on GPCRs
Seiya Iwata1, Kota Katayama1, Kohei Suzuki1, Ryoji Suno2, Chiyo Suno2, Takuya Kobayashi2,
Hirokazu Tsujimoto3, So Iwata3, Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst. Tech., 2Grad. Sch.
Med., Kansai Med. Univ., 3Grad. Sch. Med., Kyoto Univ.)
ソラベグロンおよびイソプレテレノールに結合した β3 アドレナリン受容体のクライオ電顕構造
Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol
Ikko Nureki1, Tatsuki Tanaka1, Kazuhiro Kobayashi1, Asuka Inoue2, Wataru Shihoya1, Osamu Nureki1(1Grad. Sch. Sci., Univ. Tokyo, 2Grad. Sch. Pharm. Sci. Univ. Tohoku)
The Off-Axis Rotor of Enterococcus hirae V-type ATPase by Volta Phase Contrast andConventional Phase Cryo-EM
Raymond N. Burton-Smith1, Jun Tsunoda1,2, Chihong Song1,2, Hiroshi Ueno3, Takeshi Murata4,
Ryota Iino5, Kazuyoshi Murata1,2 (1ExCELLS, Okazaki, Japan, 2SOKENDAI, Okazaki, Japan, 3Univ.
Tokyo, Tokyo, Japan, 4Chiba Univ. Chiba, Japan, 5IMS, Okazaki, Japan)
PANX1 の K346E 変異型の発現系の確立と構造的基盤の検討
Establishment of the expression system and structural basis of the K346E mutation of PANX1
Kana Taniguchi, Taiichi Tsuyama, Ken Yokoyama (Department of Molecular Biosciences, Kyoto
Sangyo)Structural insights into the HBV receptor and bile acid transporter NTCP
Jae-Hyun Park1, Masashi Iwamoto2, Ji-Hye Yun3, Tomomi Uchikubo-Kamo4, Donghwan Son3,
Zeyu Jin1,3, Hisashi Yoshida1, Mio Ohki1, Naito Ishimoto1, Kenji Mizutani1, Mizuki Oshima2,5,Masamichi Muramatsu2, Takaji Wakita2, Mikako Shirouzu4, Kehong Liu6, Tomoko Uemura6,
Norimichi Nomura6, So Iwata6,7, Koichi Watashi2,5,8, Jeremy R. H. Tame1, Tomohiro Nishizawa1,
Weontae Lee3, Sam-Yong Park1 (1Grad. Sch. MLS, Yokohama City University, 2Department of Virology
II, National Institute of Infectious Diseases, 3Department of Biochemistry, College of Life Science andBiotechnology, Yonsei University, 4Laboratory for Protein Functional and Structural Biology, RIKEN
Center for Biosystems Dynamics Research, 5Department of Biological Sciences, Tokyo University of
Science, 6Department of Cell Biology, Graduate School of Medicine, Kyoto University, 7RIKEN SPring-8
Center, 8Research Center for Drug and Vaccine Development)
インフルエンザ菌アドヘシンの膜貫通ドメインのナノディスクへの挿入における BamA の役割
Role of BamA on the insertion of the transmembrane domain of Haemophilus Influenzae
adhesin into nanodiscs
Eriko Aoki1, Kazuo Fujiwara2, Masamichi Ikeguchi2 (1GaLSIC, Soka Univ., 2Dept. Biosci., Soka Univ.)

核酸結合蛋白質／Nucleic acid binding proteins
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3Pos104

大腸菌 UvrD C 末端アミノ酸欠損変異体の DNA 結合・巻き戻しダイナミクス
Dynamics of DNA binding and unwinding by Escherichia coli UvrD lacking C-terminal aminoacids
Hiroaki Yokota (Grad. Sch. Creation New Photon. Indust.)
転写因子 Nanog についての粗視化および全原子分子動力学シミュレーション
Coarse-grained and all-atom molecular simulations for transcription factor Nanog
Azuki Mizutani1, Cheng Tan2, Yuji Sugita2, Shoji Takada1 (1Grad. Sch. Sci., Univ. Kyoto, 2RIKEN,
Comput. Sci.)– S179 –3Pos105

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スピンラベル ESR による HP1 天然変性ヒンジ領域と DNA 相互作用の動的構造解析
Dynamics of HP1 intrinsic disorderd hinge region with DNA measured by site-directed spinlabeling-ESR spectroscopy
Isao Suetake2,4, Kazunobu Sato3, Tohru Kawakami4, Tomoaki Sugishita4, Risa Mutoh5, Yuichi Mishima4,
Takeji Takui3, Toshimichi Fujiwara4, Hironobu Hojo4, Makoto Miyata1, Toshiaki Arata1,4 (1Dept.Biol.
Grad. Sch. Sci. Osaka Met.Univ., 2Nakamura Gakuen Univ., 3Dept.Chem. Grad. Sch. Sci. Osaka
Met.Univ., 4IPR. Osaka Univ., 5Fac. Sci. Toho Univ.)
Through the Looking-Glass: Functional ‘Ambidexterity’ in an Ancient Nucleic Acid Binding
ProteinLiam M Longo1, Orit Ktorza2, Yael Fridmann Sirkis3, Dragana Despotović3, Norman Metanis2 (1EarthLife Science Institute, Tokyo Institute of Technology, Japan, 2The Hebrew University of Jerusalem, Israel,
3The Weizmann Institute of Science, Israel)

水・水和／電解質／Water & Hydration & Electrolyte
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3Pos1103Pos1113Pos1123Pos113

分子動力学法を用いたシニョリン及び変異体周囲の水和ダイナミクスの解明
Elucidation of hydration dynamics around chignolin and mutants using molecular dynamics
Yui Nakamura1, Ryutaro Inou1, Shingo Nobunaga1, Takuya Takahashi2 (1Grad. Sch. Life Sci.,
Ritsumeikan Univ., 2Affiliation 1 所属 1: Coll. Life Sci., Ritsumeikan Univ.)
溶質周囲の水分子の配置・立体構造の歪みを解析するツール開発
Development of a program to analyze water's structure around solutes and the applications
Ryutaro Inou1, Yui Nakamura1, Takuya Takahashi2 (1Grad. Sch. Life Sci., Univ. Ritsumeikan, 2Coll. Life.
Sci., Univ. Ritsumeikan)
データ駆動的に構築した記述子を用いた液相水分子の静的・動的構造の研究
Static and dynamic structure of liquid water investigated by means of data-driven atomic
descriptor
Taku Mizukami1, Viet Cuong Nguyen2, Hieu Chi Dam3 (1JAIST Materials Science, 2HPC systems,
3JAIST Knowledge Science)
サブテラヘルツ波照射によるタンパク質水和の非熱的促進：誘電緩和測定による解析
Nonthermal acceleration of protein hydration by sub-terahertz irradiation: Analysis of dielectricrelaxation measurements
Masahiko Imashimizu, Jun-ichi Sugiyama, Masahito Tanaka (National Institute of Advanced Industrial
Science and Technology)
濃厚な糖溶液の構造：単糖類と二糖類の特性の比較とトレハロースの特異性
Structures of concentrated sugar solutions: Comparison of characteristics of mono- anddisaccharides and specificity of trehalose
Mitsuhiro Hirai (Gunma Univ.)
MD と 3D-RISM 理論による SARS-CoV-2 スパイクタンパク質と ACE2 タンパク質間相互作用の研究
MD and 3D-RISM study of the interaction between SARS-CoV-2 spike and ACE2 proteins
Yutaka Maruyama1, Ayori Mitsutake1, Norio Yoshida2 (1Dep. Phys., Meiji Univ., 2Grad. Sch. Info.,
Nagoya Univ.)
ガン関連タンパク質 MDM2 のリガンド結合能に対する共溶媒効果の定量的評価
Quantitative evaluation of cosolvent effects on ligand binding abilities of cancer-associatedprotein MDM2
Naoki Komiya, Kento Kasahara, Nobuyuki Matubayasi (Division of Chemical Engineering, Graduate
School of Engineering Science, Osaka University)– S180 –3Pos114

3Pos115タンパク質およびその多量体の共溶媒添加に伴う安定性変化のエネルギー解析
Free-energy Analysis of Stability Change of Proteins and Their Oligomers upon Addition of
CosolventYuka Hamada, Kento Kasahara, Nobuyuki Matubayasi (Division of Chemical Engineering, Graduate
School of Engineering Science, Osaka University)
統計熱力学に基づくペプチド薬デザイン法の開発
Computational study for designing peptide drugs based on statistical thermodynamics
Shunsuke Miyamoto, Tomohiko Hayashi (Grad. Sch. Sci. and Tech., Niigata Univ.)

分子遺伝・遺伝情報制御／Molecular genetics & Gene expression
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C. elegans のスプライシング因子 AQR の温度耐性への関与
A homolog of splicing factor AQR, emb-4, is involved in high and low temperature tolerance inC. elegans
Yuki Sato1,2, Kazuho Isono4, Teruaki Taji4, Akane Ohta1,2, Atsushi Kuhara1,2,3 (1Graduate school of
Natural Science Konan University, Kobe, Japan, 2Institute for Integrative Neurobiology, Konan
University, Kobe, Japan, 3PRIME, AMED, 4Tokyo University of agriculture, Japan)
Photocontrol of small GTPase Ras using its regulatory factor GEF modified with photochromic
azobenzene derivative
Yuichi Imamura, Nobuyuki Nishibe, Kazunori Kondo, Shinsaku Maruta (Grad.Sch.Sci.,Univ.Soka/
Japanese)

発生・分化／Development & Differentiation
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3Pos121(2SAP-4) グラフニューラルネットワークによる細胞間の時空間相互作用の推定(2SAP-4) Graph-based machine learning reveals rules of spatiotemporal cell interactions intissues
Takaki Yamamoto1, Katie Cockburn2, Valentina Greco2,3, Kyogo Kawaguchi1,4,5 (1Nonequilibrium
Physics of Living Matter RIKEN Hakubi Research Team, RIKEN BDR, 2Department of Genetics, Yale
School of Medicine, 3Departments of Cell Biology and Dermatology, Yale Stem Cell Center, Yale Cancer
Center, Yale School of Medicine, 4RIKEN CPR, 5Universal Biology Institute, The University of Tokyo)
ニワトリ胚心臓の発生にエタノールが与える影響の SS-OCT 観測
Heart development of chick embryo under ethanol exposure imaged by Swept Source OCT
Taichi Furuta, Takashi Yamaoka, Keisuke Matsubara, Yuuta Moriyama, Toshiyuki Mitsui (Dept. Phys.
Sch. Sci. Aogaku Univ.)
Observation of calcium and mitochondrial activity in mouse sperm state changes
Yuichi Hiramatsu, Takashi Ijiri (Dept. of Lif. Sci., Fac. of Sci. and Eng., Setsunan Univ.)
Analysis of the gene expression fluctuation and post-differentiation state in the differentiating
human pluripotent stem cells
Kensuke Sasaki, Sayaka Yamamoto, Yasuhiro Maeda, Tomonobu Watanabe (RIKEN Center for
Biosystems Dynamics Research)– S181 –筋肉（筋蛋白質・収縮）／Muscle
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深層学習を利用した電子線トモグラフィー法による心筋サルコメア構造のタンパク質分類の検討
Classification of muscle tissue components elucidated by electron tomography and deeplearning
Mayu Yasuda1, Wataru Kedouin1, Ryu Takeya2, Takuo Yasunaga1 (1Grad. Sch. Comp. Sci. Syst. Eng.,
KIT, 2Dept. of Pharma., Univ. of Miyazaki)
滑り運動中のアクチン繊維内に沿って生じる局所的な内部コンフォメーション変化とその伝播
Local conformational changes and the propagation along an actin filament during in vitro
motility assay
Kuruto Toda1, Hirotaka Itou1, Ichiro Nishikata2, Kenji Kamimura3, Ikuko Hujiwara4, Hajime Honda4(1Dept. of Bioeng., Nagaoka Univ. of Tech., 2Electron. and Mech. Syst. Eng. Adv. Crs., NIT, Nagaoka
Coll., 3Dept. of Electron. Control Eng., NIT, Nagaoka Coll., 4Dept. of Matl. Sci. and Bioeng., Nagaoka
Univ. of Tech.)
温められた心筋は安定性と不安定性を併せ持った収縮リズムを刻むThe warmed myocardium creates a contractile rhythm that combines stability and instability
Seine A. Shintani1,2 (1Department of Biomedical Sciences, College of Life and Health Sciences, Chubu
University, 2Center for Mathematical Science and Artificial Intelligence, Chubu University)
コフィリン結合によるアクチン繊維のアロステリック応答解明に向けた分子動力学計算
Molecular dynamics simulation to study the long-range allostery of an actin filament due tocofilin binding
Kyoko Shimanuki1, Jun Ohnuki2, Mitsunori Takano1 (1Dept. of Pure & Appl. Phys., Grad. Scl. Adv. Sci.
& Eng., Waseda Univ., 2Inst. for Mol. Sci.)
マウス心筋細胞で認める高静水圧誘発性緩徐収縮
High hydrostatic pressure induces slow contraction in mouse cardiomyocytes
Yohei Yamaguchi1, Masayoshi Nishiyama2, Hiroaki Kai3, Toshiyuki Kaneko1, Keiko Kaihara3,
Gentaro Iribe1, Akira Takai1, Keiji Naruse3, Masatoshi Morimatsu3 (1Dept. Physio., Asahikawa Med.
Univ., 2Dept. Physics, Kindai Univ., 3Dept. Cardio. Physio., Grad. Sch. Med. Dent. Pharm., Okayama
Univ.)

分子モーター／Molecular motor
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クライオ電子顕微鏡による ATP 合成酵素 FoF1 の化学力学共役機構の解明
Molecular Basis of the Chemo-Mechanical Coupling Mechanism in the ATP-Driven Rotation of
ATP Synthase FoF1
Atsuki Nakano1, Jun-ichi Kishikawa2, Atsuko Nakanishi3, Ken Yokoyama1 (1Fac. of Life Sci., Kyoto
Sangyo Univ, 2Institute for Protein Research, Osaka University, 3Research Center for Ultra-High Voltage
Electron Microscopy, Osaka University)(2SCA-4) 1 分子回転操作実験によって解明されたミトコンドリア由来 ATP 合成酵素における阻害因子 IF1 の一方向制御機構(2SCA-4) Unidirectional regulation of ATPase factor 1 in mitochondrial ATP synthase studied
by single-molecule manipulation experiments
Ryohei Kobayashi1,2, Hiroshi Ueno1, Kei-ichi Okazaki2, Hiroyuki Noji1 (1Appl. Chem., Grad. Sch. Eng.,
Univ. Tokyo, 2Inst. for Mol. Sci.)
Drug binding to the mycobacterial ATP synthase – mechanistic implications
Alexander Krah1, Gerhard Grüber2, Peter J. Bond1,3 (1Bioinformatics Institute, 2Nanyang Technological
University, 3National University of Singapore)– S182 –3Pos130

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3Pos1413Pos142Single-molecule analysis and engineering of rotary V-ATPase
Akihiro Otomo1,2, Tatsuya Iida1,2, Hiroshi Ueno3, Takeshi Murata4, Ryota Iino1,2 (1Institute for
Molecular Science, 2SOKENDAI, 3Grad. Sch. Eng., The Univ. of Tokyo, 4Grad. Sch. Sci., Chiba Univ.)
Acrive structures of V/A-type rotary ATPase reveal the rotary catalytic mechanism
Jun-ichi Kishikawa1, Atsuko Nakanishi2, Atsuki Nakano3, Ken Yokoyama3 (1Inst. Prot. Res., Osaka
Univ., 2Res. Ctr. UHVEM, Osaka Univ., 3Dept. Adv. Life. Sci., Kyoto Sangyo Univ.)
全原子分子動力学計算による KIF1A の微小管への結合過程の解析
All-atom molecular dynamics simulation analysis of KIF1A binding to microtubule
Koki Adachi, Mitsunori Takano (Dept. of Pure & Appl. Phys., Grad. Scl. Adv. Sci. & Eng., Waseda
Univ.)
微小管とキネシンによる三次元のモティリティアッセイの実現
Realization of three-dimensional motility assay with microtubules and kinesin
Hisanori Saito1, Ibuki Kawamata1, Gikyo Usuki2, Kohei Nishiyama2, Shinichiro Nomura1,
Nathanael Aubert-Kato3, Akira Kakugo2, Satoshi Murata1 (1Grad. Sch. Eng., Univ. Hyogo, 2Grad. Sch.
Sci., Univ. Hokkaido, 3Grad. Sch. Sci., Univ. Ochanomizu)
KIF5A の ALS 関連遺伝子変異は KIF5A のオリゴマー化と凝集を促進し神経毒性を引き起こすAn ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronaltoxicity
Kyoko Chiba1, Juri Nakano2, Shinsuke Niwa1 (1FRIS, Tohoku Univ., 2Grad. Sch. of Life Sci., Tohoku
Univ.)ADP 解離の遅い変異体を用いたキネシン 1 の連続的歩行能を決める要因の研究
High-speed single molecule study of the determinant of kinesin-1’s processivity using mutants
with slow ADP-release
Yuta Miyazono, Hiroki Hayano, Tukasa Enomoto, Michio Tomishige (Grad. Sch. Sci. Eng., Aoyama
Gakuin Univ.)
KIF1A/ダイニンが制御する軸索内小胞プールサイズ
Vesicle pool sizes controlled by axonal transport of KIF1A/dynein
Yuki Kagawa1, Ryo Sasaki1, Yuzu Anazawa2, Shinsuke Niwa3, Kumiko Hayashi1 (1Grad. Sch. Eng.,
Tohoku Univ., 2Grad. Sch. Life Sci., Tohoku Univ., 3FRIS., Tohoku Univ.)
Dpcd ノックアウトマウスの側脳室における内腕ダイニンの遺伝子発現と脳室内の流れの解析
Analysis of inner arm dynein gene expression and intraventricular flow in the lateral ventricleof Dpcd knockout mice
Hironori Ueno1, Daiki Yamamoto2, Kazuhito Takeuchi2, Yuichi Nagata2, Fumiharu Ohka2,
Atsushi Natsume2, Ryuta Saitou2 (1Aichi Univ. of Edu., 2Grad. Sch. of Med., Nagoya Univ.)
ミュータントの S1 による F アクチンの協同的構造変化の伝播距離の推定
Estimation of propagation distance of cooperative conformational changes in F-actin induced
by a mutant S1
Masahiro Miura, Taro QP Uyeda (Department of Pure and Applied Physics, Graduate School of
Advanced Science and Engineering, Waseda University)
ダイニンによる細胞内輸送が細胞質動態から受ける影響について
Effect of cytoplasmic dynamics on dynein-dependent transports
Takayuki Torisawa1,2, Akatsuki Kimura1,2 (1Cell Arch. Lab., Natl. Inst. Genet., 2Dept. Genet.,
SOKENDAI)
減圧顕微鏡法によって測定されたバクテリア運動能
Bacterial motility measured by depressurization microscopy
Masayoshi Nishiyama (Kindai Univ.)
The relative motion of MotA around MotB in bacterial flagellar stator
Phuoc Duy Tran, Akio Kitao (Sch. Life Sci. Tech., TokyoTech)
Single particle cryo-EM of Paenibacillus stator complex reveals the flexibility of the pentameric
MotA1 ring
Sakura Onoe1, Tatsuro Nishikino2, Nobuhiro Takekawa3, Jun-ichi Kishikawa2, Takayuki Kato2 (1FBS,
Osaka Univ., 2IPR, Osaka Univ., 3Dep. Macromol. Sci., Osaka Univ.)– S183 –3Pos143

3Pos144(2SFA-6) SLC26 陰イオントランスポーターによる電気→運動エネルギー変換(2SFA-6) SLC26 ion transporters act as electricity-driven motor proteins
Tomohiro Shima (Grad. Sch. Sci., Univ. Tokyo)
速く動く DNA ナノ粒子モーターはつくれるか？シミュレーションによる検討
How to engineer fast-moving DNA-nanoparticle motor? A simulation study
Takanori Harashima, Akihiro Otomo, Ryota Iino (Institute for Molecular Science)

細胞生物学的課題（接着，運動，骨格，伝達，膜）／Cell biology
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3Pos152

Fimbrin の協同的相互作用による F-actin の長さの変化
Changes in actin filament length induced by the cooperative interaction of fimbrin
Ryosuke Tsunabuchi1, Naoki Hosokawa1, Rika Hirakawa1, Masahiro Kuragano1, Taro Q.P Uyeda2,
Kiyotaka Tokuraku1 (1Graduate School of Engineering, Muroran Institute of Technology, 2Department of
Physics, Faculty of Science and Engineering, Waseda University)
魚類ケラトサイトのストレスファイバ直動回転変換メカニズム
Linear contraction of stress fibers kicks the substratum for their rotation
Chika Okimura1, Shu Akiyama1, Tatsunari Sakurai2, Yoshiaki Iwadate1 (1Dept.Biol., Yamaguchi Univ.,
2Dept.Math.Eng., Musashino Univ.)
G146V とそのサプレッサー変異は酵母のアクチンダイナミクスに影響する
G146V and its suppressor mutations in yeast actin suggested to affect actin dynamics in vivo
Tenji Yumoto1, Taro QP Uyeda1, Takehiko Yoko-o2 (1Department of Pure and Applied Physics,
Graduate School of Advanced Science and Engineering, Waseda University, 2Cellular and Molecular
Biotechnology Research Institute, AIST)気管形成におけるアクチン骨格のミクロ相分離と自己組織化構造の転移ダイナミクス
Microphase separation and transition dynamics of self-organized structures of actin
cytoskeleton during tubulogenesis
Mitsusuke Tarama1, Sayaka Sekine2, Tatsuo Shibata1, Shigeo Hayashi1 (1RIKEN BDR, 2Grad. Sch. Life
Sci., Tohoku Univ.)
アクトミオシンの収縮による膜変形の再構成
Morphological transitions of lipid vesicles driven by the contraction of actomyosin networks
Makito Miyazaki1,2,3,4, Fahmida Sultana Laboni5, Masatoshi Ichikawa2, Taeyoon Kim5 (1Hakubi, Kyoto
Univ., 2Dept. Phys., Kyoto Univ., 3Inst. Curie, 4PRESTO, JST, 5Biomed. Eng., Purdue Univ.)
人工細胞内アクチン光操作が可能にする細胞運動の再構成
Synthesizing motility in artificial cells by asymmetrically reconstituted actin polymerization
Hideaki Matsubayashi1,2, Shiva Razavi2,3, Hideki Nakamura2,4,5, Daniel A. Kramer6,
Tomoaki Matsuura7, Baoyu Chen6, Takanari Inoue2 (1Frontier Research Institute for Interdisciplinary
Sciences, Tohoku University, 2Department of Cell Biology, School of Medicine, Johns Hopkins
University, 3Department of Biological Engineering, School of Engineering, Massachusetts Institute ofTechnology, 4Hakubi Center for Advanced Research, Kyoto University, 5Department of Synthetic
Chemistry and Biological Chemistry, School of Engineering, Kyoto University, 6Roy J. Carver
Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 7Earth-Life
Science Institute, Tokyo Institute of Technology)
Probing the influence of geometrical constraints on collective cell dynamics in diameter-varying
3D gelatin tube structures
Mitsuru Sentoku, Kenji Yasuda (Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ.)
プリント化したフィブロネクチン勾配に対する好中球の走触性の解析
Analysis of neutrophil haptotaxis on printed fibronectin gradients
Yoshino Tanaka1, Gen Honda2, Masahito Uwamichi3, Satoshi Sawai3 (1Grad. Sch. Sci., Univ. Tokyo,
2Komaba institute for science, Grad. Sch. Arts & Sci., Univ. Tokyo, 3Grad. Sch. Arts & Sci., Univ. Tokyo)– S184 –3Pos153

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細胞性粘菌の運動において bleb モードへの転換は Ca2+流入に依存しない
The transition to bleb mode is independent on extracellular Ca2+ influx in Dictyostelium
discoideum motility
Hitomi Takeuchi, Taro QP Uyeda (Department of Pure and Applied Physics, Graduate School of
Advanced Science and Engineering, Waseda University)
Velocity field dynamics under blurring in fluorescent images of dictyostelium discoideum
colonies
Md Mohiuddin7,8, Md Motaleb Hossain1,2, Sulimon Sattari1, Udoy S. Basak1,3, Mikito Toda4,
Kazuki Horikawa5, Tamiki Komatsuzaki1,6,7 (1Research Institute for Electronic Science, Hokkaido
University, Japan, 2University of Dhaka, Bangladesh, 3Pabna University of Science and Technology,
Bangladesh, 4Nara Women's University, Japan, 5Tokushima University Graduate School, Japan,
6Institute for Chemical Reaction Design and Discovery (ICReDD), Hokkaido University, Japan,
7Graduate School of Chemical Sciences and Engineering, Hokkaido University, Japan, 8Mathematics
Discipline, Comilla University, Bangladesh)
The dominant factor of shapeshifts of collective cell migration between sheet form and clusters
in flexible 3D tunnel structures
Wataru Hanamoto1, Miki Takei1, Masaharu Endo2, Kaito Asahi2, Mitsuru Sentoku2, Kenji Yasuda1,2(1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ, 2Dept. Pure & Appl. Phys., Grad. Sch.
Adv. Sci. & Eng., Waseda Univ.)
二次元制限空間内を進行する細胞集団の流体的振る舞いの計測
Measuring the fluid-like behavior of collective cell migration in two-dimensional restrictedstructures
Miki Takei1, Masaharu Endo2, Mitsuru Sentoku2, Kaito Asahi2, Wataru Hanamoto1, Kenji Yasuda1,2(1Dept. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch. Adv. Sci. &Eng., Waseda Univ.)
CheZ 局在の大腸菌走化性に及ぼす影響のキャピラリーアッセイによる解析
Analysis for the effect of CheZ localization on chemotaxis of Escherichia coli by capillary assay
Sawako Matsuda1, Yong-Suk Che1, Akihiko Ishijima1, Masaru Kojima2, Hajime Fukuoka1 (1Grad. Sch.
Frontier Biosci. Osaka Univ, 2Grad. Sch. Engineering Sci. Osaka Univ)
CheB の極性局在を利用した異種走化性受容体の忌避刺激に対する応答性の比較
Comparison of responses to repellent stimulus at heterogeneous MCPs through polar
localization of CheB
Shinnosuke Kawahara, Yumiko Uchida, Yong-Suk Che, Akihiko Ishijima, Hajime Fukuoka (Grad. Sch.
Frontier Biosci. Osaka Univ.)
バクテリアの群れ運動における局所的な細胞間相互作用と運動制御
Local cell interaction and motility regulation for swarm motility of bacteria
Kodai Suzuki, Ikuro Kawagishi, Masatoshi Nishikawa (Grad. Sch. Fun., Univ. Hosei)
クラミドモナス繊毛交互打ち変異株の解析
Analysis of a Chlamydomonas mutant showing alternate ciliary beatings
Kazuma Sakamoto1,2, Atsuko Isu1, Toru Hisabori1,2, Ken-ichi Wakabayashi1,2 (1Lab. Chem. Life Sci.,
Tokyo Tech., 2Sch. Life Sci. Tech., Tokyo Tech)
海洋性ビブリオ菌におけるべん毛本数制御因子 FlhF と MS リング構成因子 FliF の相互作用解析
Interactions between the flagellar number regulator FlhF and the MS ring protein FliF in Vibrio
alginolyticus
Yuria Fukushima, Seiji Kojima, Michio Homma (Div. Biol. Sci., Grad. Sch. Sci., Nagoya Univ.)
Functional and structural analyses of FlaK, a master regulator of the genes involved in polar
flagellar formation in marine Vibrio
Seiji Kojima1, Tomoya Kobayakawa1, Yuxi Hao1, Tatsuro Nishikino2, Michio Homma1 (1Div. of Biol.
Sci., Grad. Sch. Sci., Nagoya Univ., 2Inst. for Prot. Res., Osaka Univ.)– S185 –3Pos163

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カルシウム感受性があるクラミドモナス鞭毛内部構造のラセン配置
The Calcium Sensitive Helical Arrangement of Axonemal Structures in Chlamydomonas
Flagella
Hitoshi Sakakibara1, Kenta Ishibashi1, Hiroyuki Iwamoto2, Hiroaki Kojima1, Kazuhiro Oiwa1,3 (1BioICT, Nat. Inst. Inf. Com. Tech., 2SPring-8, JASRI, 3Life Sci. Univ. Hyogo)
大腸菌べん毛モーター間の回転方向転換同調を阻害する走化性受容体クラスター内における野生型/変異体比率の見積もり
Estimation of mutant/WT receptors ratios in receptor array that disrupts the switching
coordination between flagellar motors of E. coli
Yumiko Uchida, Hajime Fukuoka, Akihiko Ishijima, Yong-Suk Che (Grad. Sch. Frontier Biosci. Osaka
Univ.)
回転する大腸菌べん毛モーター中の GFP-FliL 局在の定量解析
Quatitative analysis of GFP-FliL localization at rotating flagellar motor of E. coli.
Miyuto Miyazaki, Yumiko Uchida, Hajime Fukuoka, Akihiko Ishijima, Yong-Suk Che (Grad. Sch.
Frontier Biosci. Osaka Univ.)
キイロショウジョウバエの精子鞭毛の波形と鞭毛打頻度
The waveform and beat frequency of a sperm flagellum of Drosophila melanogaster
Sho Tamai1,2, Kosei Sato1,3, Hitoshi Sakakibara1, Kazuhiro Oiwa1,3 (1Adv.ICT Res.Inst.,NICT, 2Sch. Sci.,
Univ. Hyogo, 3Grad. Sch. Sci., Univ. Hyogo)
ピエゾ駆動対物レンズを用いたホヤ精子遊泳の 3 次元的解析
3D analysis of ascidian sperm swimming using a piezoelectric Z-scanner attached to a
microscope objective
Kogiku Shiba, Kazuo Inaba (Shimoda Marine Research Center, Univ. Tsukuba)
蛍光共鳴エネルギー移動(FRET)によるタウ–微小管相互作用の熱力学的解析
Thermodynamic analysis of tau–MT interaction by Forster resonance energy transfer (FRET)
Riku Kiyonaka, Hideyuki Komatsu (Dept. of Bioscience and Bioinformatics, Kyushu Inst. Tech.)
FRET 計測系を用いた低濃度セリンに対する単一大腸菌受容体の協同作用による 2 種類の適応
Two behaviors of adaptation by cooperative action of a single E. coli receptor to low
concentrations of serine using FRET measurement
Yuki Takada, Akihiko Ishijima, Hajime Fukuoka, Yong-Suk Che (Graduate School of Frontier
Biosciences Osaka University)
BAR ドメインタンパク質による細胞間接着の維持
Maintenance of cell-cell adhesions by BAR domain proteins
Yosuke Senju (RIIS, Univ. Okayama)
スパイロプラズマの細胞分裂タンパク質の機能解析
Functional analysis of Spiroplasma cell division proteins
Taishi Kasai1, Yuhei Tahara2, Makoto Miyata2, Daisuke Shiomi1 (1Rikkyo University，College of
Science, 2Osaka Metropolitan University, Graduate School of Science)
細胞外小胞の受容細胞への内在化と膜融合効率の検討
Investigation of the efficiency of internalization of extracellular vesicles and their membranefusion with recipient cells
Hisaaki Hirose, Yusuke Hirai, Shiroh Futaki (ICR, Kyoto Univ.)
レプトスピラの運動性や物性、病原性に与える外膜分子の影響
Effect of the outer membrane (OM) molecules on the motility, physical property, andpathogenicity of Leptospira
Keigo Abe1, Nobuo Koizumi2, Shuichi Nakamura1 (1Grad. Sch. Eng., Univ. Tohoku, 2Dept. of
Bacteriology I, National Inst. of Infectious Disease)
自律拍動心筋細胞ネットワークにおける強制発火周期の記憶化
Memorization of forced firing intervals in spontaneous beating cardiomyocyte networks
Akira Nishizaki1, Yoshitsune Hondo2, Suguru Matsumoto2, Kazuhumi Sakamoto2, Kenji Yasuda1,2(1Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Grad. Sch.
Adv. Sci. & Eng., Waseda Univ.)– S186 –3Pos175

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Plasticity of synchronized beating during connecting and separating of cardiomyocyte networks
Suguru Matsumoto1, Kazufumi Sakamoto1, Akira Nishizaki2, Kenji Yasuda1,2 (1Dept. Pure & Appl.
Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure & Appl. Phys., Sch. Adv. Sci. & Eng.,
Waseda Univ.)
緩やかな温度上昇による心筋細胞の拍動揺らぎの抑制
Depression of beating fluctuation in cardiomyocytes by gradual temperature rising
Kohei Oyama, Masahito Hayashi, Tomoyuki Kaneko (LaRC., Dept. Frontier Biosci., Hosei Univ.)
哺乳動物細胞におけるコレステロール依存的な熱吸収機構
Cholesterol-dependent mechanism underlying heat absorption in mammalian cells
Akira Murakami1,2, Tasuku Sato1, Kohki Okabe1, Takashi Funatsu1 (1Grad. Sch. Pharm. Sci., Univ
Tokyo, 2Grad. Sch. Pharm. Sci., Univ Shizuoka)
自己融解酵素によるグラム陽性細菌の溶菌過程の高速 AFM 観察
High-speed AFM observation of the lysis process of Gram-positive bacterial cell by autolysin
Yumu Ota1, Hayato Yamashita1, Kotaro Higashi2, Masaya Yamaguchi2, Shigetada Kawabata2,
Masayuki Abe1 (1Grad. Sch. of Eng. Sci., Osaka Univ., 2Grad. Sch. of Den., Osaka Univ.)
Application of three-dimensional holotomography in label-free living cells
Seongsoo Lee, Jae-Hyuk Lee (Korea Basic Science Institute Gwangju Center, Gwangju 61751, South
Korea)
細胞応答評価のためのマルチモーダル刺激可能なマイクロハンドの開発
Development of microhand with multimodal stimulus system for evaluation of cellular response
Masaru Kojima1, Kazuma Koshide1, Yasushi Mae2, Tatsuo Arai3 (1Grad. Sch. Eng.Sci., Osaka Univ.,
2Fac. of Eng. Sci., Kansai Univ., 3UEC)

生体膜・人工膜：構造・物性／Biological & Artificial membrane: Structure & Property
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皮膚線維芽細胞の長期培養による粘弾性への影響
Effect of long-term culture of skin fibroblasts on viscoelasticity
Kosuke Matsumura1, Akira Kabasawa1, Sayaka Miyoshi3, Michiya Matsusaki4,
Arif Md. Rashedul Kabir1,2, Teruki Yanagi5, Kazuki Sada1,2, Akira Kakugo1,2,
Kaori Shigetomi（Kuribayashi）3 (1Grad. Sch. of Chem. Sci. and Eng., Hokkaido Univ., 2Fac. of Sci.,
Hokkaido Univ.,, 3Institute for the Advancement of Higher Education, Hokkaido Univ., 4Grad. Sch. ofEng., Osaka Univ., 5Department of Dermatology, Faculty of Medicine and Graduate School of Medicine,
Hokkaido Univ.)
細胞性粘菌の生細胞での膜タンパク質分子の多状態側方拡散運動の細胞膜フィールドモデルの構築
Field model for lateral diffusion of transmembrane proteins in Dictyostelium cells
Kazutoshi Takebayashi1, Yoichiro Kamimura2, Masahiro Ueda1,3 (1BDR., RIKEN, 2Nara Med. Univ.,
3Grad. Sch. Front. Biosci., Osaka Univ.)
Unraveling the host-selective toxic interaction of cassiicolin with lipid membranes and its
cytotoxicity
Kien Xuan Ngo1, Phuong Doan N. Nguyen1, Hirotoshi Furusho1, Makoto Miyata2, Tomomi Shimonaka2,
Nguyen Ngoc Bao Chau3, Nguyen Phuong Vinh4, Nguyen Anh Nghia4, Tareg Omer Mohammed1,
Takehiko Ichikawa1, Noriyuki Kodera1, Hiroki Konno1, Takeshi Fukuma1, Nguyen Bao Quoc5 (1WPINanoLSI, Kanazawa University, Kanazawa, 2Grad. Sch. Sci., Osaka City University, Osaka, 3Facult.
Biotech., Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam, 4Rubber Res. Inst. Vietnam, Ho
Chi Minh City, Vietnam, 5Res. Inst. Biotech. Environ., Nong Lam University, Ho Chi Minh City, Vietnam)– S187 –3Pos184

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分子動力学シミュレーションを用いた脂質膜におけるメリチンの抗菌作用の研究
Investigation for antimicrobial action of melittin on a lipid membrane using molecular dynamics
simulation
Yusuke Miyazaki, Wataru Shinoda (Research Institute for Interdisciplinary Science, Okayama
University)
細胞膜糖鎖構造によるウイルス感染のメカニカルな制御
Mechanical modulation of virus infection by cell membrane glycocalyx
Yoshihisa Kaizuka, Rika Machida (National Institute for Materials Science)(2SBP-3) エンベロープ型ウイルス粒子の粗視化シミュレーション：B 型肝炎ウイルス(2SBP-3) Coarse-grained Molecular Dynamics Study of Enveloped Virus Particle: Hepatitis B
Virus
Ryo Urano, Wataru Shinoda (Res. Inst. Interdiscip. Sci., Okayama Univ.)
曲率誘導タンパク質の膜曲率応答の平均場理論
Mean field theories of curvature sensing and generation of isotropic and anisotropic curvatureinducing proteins
Hiroshi Noguchi (ISSP, Univ. Tokyo)

生体膜・人工膜：ダイナミクス／Biological & Artificial membrane: Dynamics
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高分子をグラフトした脂質三成分ベシクルの膜粘度
Viscosity of polymer grafted ternary lipid vesicle
Yuka Sakuma (Grad. Sch. Sci., Tohoku Univ.)
脂質三成分ベシクルにおける膜粘度の温度依存性
Viscosity Landscape of Ternary Vesicles in Composition-Temperature Space
Juria Tanaka, Kenya Haga, Masayuki Imai, Yuka Sakuma (Grad. Sch. Sci., Tohoku Univ.)
細胞内反応拡散波の再構成に向けた膜流動性の制御手法
Improvement of the membrane fluidity to reconstitute the intracellular reaction-diffusion waves
Gen Honda1, Nao Shimada2, Satoshi Sawai2,3, Miho Yanagisawa1,2,3 (1Komaba Institute for Science,
Graduate School of Arts and Sciences, University of Tokyo, 2Department of Basic Science, Graduate
School of Arts and Sciences, University of Tokyo, 3Research Center for Complex Systems Biology,
Graduate School of Arts and Sciences, University of Tokyo)
抗菌ペプチドの抗菌および殺菌活性の単一細胞解析
Single cell analysis for antimicrobial and bactericidal activities of antimicrobial peptides (AMPs)
Farzana Hossain1, Masahito Yamazaki1,2,3 (1Res. Inst. Ele., Shizuoka Univ., 2Grad. Sch. Sci. Tech.,
Shizuoka Univ., 3Grad. Sch. Sci., Shizuoka Univ.)
浸透圧ストレス下における脂質二重膜の挙動に対し、F-actin が及ぼす影響
Effect of F-actin on the behavior of lipid bilayers under osmotic stressKen Bessho, Moka Ito, Kingo Takiguchi (Dept. Biol. Sci., Grad. Sch. Sci., Nagoya Univ.)
クロモグリク酸ナトリウム液晶封入リポソーム上の 3 本縞様膜相分離
Three-stripe pattern of lipid domains on spindle-shaped liposome containing liquid crystal of
disodium cromoglycate
Kaori Udagawa, Masahito Hayashi, Tomoyuki Kaneko (LaRC., Dept. Frontier Biosci., Hosei Univ.)
クラミドモナス含有リポソームの鞭毛運動と膜運動の高速イメージング
High-speed imaging of the flagellar beating and membrane motion of Chlamydomonas
containing liposome
Shunsuke Shiomi, Masahito Hayashi, Tomoyuki Kaneko (Graduate School of Science and Engineering,
Hosei University.)– S188 –生体膜・人工膜：興奮・チャネル／Biological & Artificial membrane: Excitation & Channels
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コリネ型細菌の機械受容チャネル MscCG の人工脂質膜リポソームへの再構成と電気生理学的特性
Liposome reconstitution and electrophysiological characterization of Corynebacterium
glutamicum mechanosensitive channel MscCG.
Yoshitaka Nakayama1,2, Paul Rohde1, Tomoyuki Konishi3, Hisashi Kawasaki3,4, Boris Martinac1,2(1Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, 2St Vincent's
Clinical School, Faculty of Medicine, The University of New South Wales, 3Agro-Biotechnology ResearchCenter, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 4Collaborative
Research Institute for Innovative Microbiology, The University of Tokyo)
KcsA カリウムイオンチャネルにおける膜張力感知部位の探索
Exploring the membrane tension sensing sites in the KcsA potassium channel
Misuzu Ueki1, Masami Miyagoshi1, Shigetoshi Oiki2, Masayuki Iwamoto1 (1Dept. Mol. Neurosci.,
Facul. Med. Sci., Univ. Fukui., 2Biomed. Imaging Res. Center, Univ. Fukui)
KcsA カリウムチャネルゲーティングに対する膜厚と膜張力の作用
Concurrent effect of the membrane thickness and tension on the gating of the KcsA potassiumchannelYuka Matsuki1, Masayuki Iwamoto2, Masako Takashima2, Shigetoshi Oiki3 (1Dept. Anesth.
Reanimatol., Univ. Fukui Fac. Med. Sci., 2Dept. Anesth. Reanimatol., Univ. Fukui Fac. Med. Sci.,
3Biomed. Imag. Res. Cent., Univ. Fukui)

神経・感覚（細胞・膜蛋白質・分子）／Neuroscience & Sensory systems
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3Pos202C.elegans の低温耐性を制御する転写伸長因子 TCEB-3 のトランスクリプトーム解析
Transcriptome analysis of a transcription elongation factor TCEB-3 that is positive regulator ofcold tolerance in C.elegans
Hiroaki Teranishi1, Toshihiro Iseki1, Natsune Takagaki1, Yohei Minakuchi2, Atsushi Toyoda2,
Akane Ohta1, Atsushi Kuhara1,3 (1Grad. school of Nat. Sci., Konan Univ, Japan, 2National Institute of
Genetics, Japan, 3PRIME, AMED)GPCR SRX は線虫の低温耐性に関わる温度受容体候補である
GPCR SRX is a thermoreceptor candidate in cold tolerance of C. elegans
Chinatsu Morimoto1, Chie Miyazaki1, Kohei Ohnishi1, Tohru Miura1, Akane Ohta1, Atsushi Kuhara1,2(1Inst. for Integrative Neurobio., Konan Univ., Japan, 2PRIME, AMED)
脳-腸連関によって制御された脂質代謝が線虫の温度順化を引き起こす
Lipid metabolism regulated by brain-gut interaction causes temperature acclimation in C.
elegans
Kazutoshi Murakami1,2, Haruka Motomura1,2, Akane Ohta1,2, Atsushi Kuhara1,2,3 (1rad. sch. Nat. Sci.,
Univ. Konan, 2Inst. Integrative Neurobio., Univ Konan, 3PRIME, AMED)
拡散追跡による脂質膜上の初期の Aβ 凝集過程に対する開放系の効果
Effect of Open System on Early Aggregation Process of Amyloid β on Lipid Membrane by
Diffusion Tracking
Akane Iida1, Hideki Nabika2 (1Graduate School of Science and Engineering, Yamagata Univ., 2Facultyof Science, Yamagata Univ.)
インスリン刺激時のモノアラガイ単離脳に対するリン酸化プロテオミクス解析
Phosphoproteomic analysis of the pond snail’s CNS stimulated by insulin
Junko Nakai, Etsuro Ito (Dept. Biol., Waseda Univ.)– S189 –神経回路・脳の情報処理／Neuronal circuit & Information processing
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fMRI データに対する行列分解による脳情報コーディング
Brain information coding in fMRI data via matrix factorization
Yusuke Endo, Koujin Takeda (Grad. Sch. Eng., Univ. Ibaraki)
機能的神経クラスタ推定のためのベイズ生成モデルの一般化
Generalization of Bayesian generative model for functional neuronal ensembles inference
Shun Kimura, Koujin Takeda (Grad. Sch. Sci. and Eng., Ibaraki Univ.)
アガロースマイクロチャネル構造における単一神経突起の分化に必要な定量的条件
Quantitative requirement for single neurite differentiation of neurons in agarose microchannel
structures
Ryohei Yamazaki1, Nanami Abe2, Yuri Kamiya2, Kenji Yasuda1,2 (1Dept. Pure & Appl. Phys., Grad.
Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Phys., Sch. Adv. Sci. & Eng., Waseda Univ.)
Evaluation of agarose microfabrication technology using Joule heat of micrometer-sized ioniccurrent for cell network formation
Yuri Kamiya1, Kenji Shimoda2, Yoshitune Hondo2, Haruki Watanabe2, Nanami Abe1,
Ryohei Yamazaki2, Kenji Yasuda1,2 (1Dept. Phys., Sch. Adv. Sci. & Eng., Waseda Univ., 2Dept. Pure andAppl. Phys., Grad. Sch. Adv. Sci. & Eng., Waseda Univ.)
線虫の神経活動解析における擬似相関の除去
Eliminating spurious correlation in neural activity analysis of C. elegans
Harutaka Takeshita, Yuishi Iwasaki (Grad. Sch. Sci. Eng., Ibaraki Univ)
遺伝子発現に基づく神経回路形成のデータ駆動型解析
Data-driven analysis of the formation of neural circuit based on gene expression
Jigen Koike1, Kana Yoshido1, Naoki Honda1,2,3 (1Graduate School of Biostudies, Kyoto University,
2Graduate School of Integrated Science for Life, Hiroshima University, 3Explatory Research Center onLife and Living Systems, ExCells)
ヨーロッパモノアラガイの摂食中枢ニューロン CGC 近傍における電気生理学的性質に対する緑茶由来カテキンの影響
The effect of green tea-derived catechin on electrophysiological properties around the CGC in
the pond snail Lymnaea stagnails
Hideki Matsuoka1, Ayaka Itoh2, Terumasa Amano2, Ken Lukowiak3, Minoru Saito2,
Yoshimasa Komatsuzaki4 (1Dept. Phys., Grad. Sch. Sci. and Tech., Nihon Univ., 2Dept. Corr. Study inPhys. and Chem., Grad. Sch. Integ. Basic Sci., Nihon Univ., 3Hotchkiss Inst., Cumm. Sch. Med., Univ. ofCalgary, Canada, 4Dept. Phys., CST, Nihon Univ.)
エピカテキンはナメクジ嗅覚中枢シナプスの長期抑圧現象を惹起する
Effects of epiatechin on synaptic plasticity of the olfactory center in the land slug Limax
valentianus
Aya Nagata, Yoshimasa Komatsuzaki (Dept. Phys., CST, Nihon Univ.)
神経細胞内シナプス小胞群の光捕捉下における神経活動測定
Neuronal activity measurement under optical trapping of synaptic vesicles in neurons
Taketo Yasuda, Wataru Minoshima, Kyoko Masui, Chie Hosokawa (Grad. Sch. Sci., Osaka Metro.
Univ. / Osaka City Univ.)
集光フェムト秒レーザーの短時間照射により誘発された神経活動
Neuronal activities induced by short-time irradiation of a focused femtosecond laser
Kan Otani, Yumi Segawa, Wataru Minoshima, Kyoko Masui, Chie Hosokawa (Grad. Sch. Sci., Osaka
Metro. Univ. / Osaka City Univ.)– S190 –行動／Behavior
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Dynamical systems model of the development of action differentiation and memory in early
infancy
Ryo Fujihira, Gentaro Taga (Grad. Sch. Edu., Univ. Tokyo)
ゾウリムシの走化性はレヴィウォークを通じて現れる
Chemokinetic responses of Paramecium tetraurelia through Lévy walks
Azusa Kage1, Takeru Wakano1, Masato S. Abe2, Takayuki Nishizaka1 (1Dept. Physics, Gakushuin Univ.,
2Facl. Culture and Information Science, Doshisha Univ.)
Near wall rheotaxis of ciliates, Tetrahymena pyriformis.
Yukinori Nishigami1, Takuya Ohmura2, Masatoshi Ichikawa3 (1RIES, Hokkaido Univ., 2Biozentrum,
Univ. Basel, 3Dept Phys., Kyoto Univ.)

光生物：視覚・光受容／Photobiology: Vision & Photoreception
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Photoactive Yellow Protein における酸性アミノ酸に置換した 52 番目の残基のプロトン化状態
Protonation state of 52nd residue replaced by an acidic amino acid in Photoactive Yellow Protein
Kento Yonezawa1,2, Yoichi Yamazaki2, Mikio Kataoka2, Hironari Kamikubo1,2 (1NAIST, CDG, 2NAIST,MS)
RcPYP と PBP の複合体形成に及ぼす PBP C 末端部位の役割
Role of PBP C-terminal region on the complex formation between RcPYP and PBP
Daiki Takenaka1, Yoichi Yamazaki1, Kento Yonezawa1,2, Sachiko Toma-Fukai1, Hironari Kamikubo1,2(1NAIST, MS, 2NAIST, CDG)
青色光センサー TePixD の光可逆的な分子集合反応
Light-dependent reversible molecular assembly of a blue light sensor protein TePixD
Yusuke Nakasone, Yusuke Masuda, Shunrou Tokonami, Masahide Terazima (Grad. Sch. Sci., Kyoto
Univ.)
深海エビ Rimicaris hybisae が持つオプシン類の分子特性
Molecular properties of opsins from the deep-sea hydrothermal vent shrimp Rimicaris hybisae
Keiichi Kojima1, Yuya Nagata2, Norio Miyamoto3, Keita Sato1, Yuji Yamanaka4, Yosuke Nishimura5,
Susumu Yoshizawa5, Ken Takai3, Hideyo Ohuchi1, Takahiro Yamashita6, Yuki Sudo1 (1Med, Dent &Pharm Sci, Inst of Acad. & Res., Okayama Univ., 2Grad. Sch. of Med. Dent. & Pharm. Sci., Okayama
Univ., 3X-STAR, JAMSTEC, 4Fac. of Pharm. Sci., Okayama Univ., 5AORI, Univ. Tokyo, 6Grad. Sch. Sci.,
Kyoto Univ.)
Investigation of spectral properties and spectral tuning mechanisms of anthozoan-specificopsins from a reef-building coral
Yusuke Sakai, Mitsumasa Koyanagi, Akihisa Terakita (Department of Biology, Graduate School of
Science, Osaka Metropolitan University)
光駆動型 Cl−ポンプ・ハロロドプシンの細胞質型ハーフチャンネルにおける高速 Cl−輸送のメカ
ニズム解明
Probing the mechanism of fast Cl− transport in the cytoplasmic half channel of light-driven Cl−pump halorhodopsin
Yubo Zhai1, Anna Shimosaka1, Takashi Tsukamoto1,2, Makoto Demura1,2, Takashi Kikukawa1,2 (1Grad.
Sch. Life Sci., Hokkaido Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)
光駆動 Cl−ポンプ halorhodopsin の基質放出・取込み中間体の同定
Identification of substrate release and uptake intermediates of light-driven Cl− pumphalorhodopsin
Chihaya Hamada1, Keisuke Murabe1, Takashi Tukamoto1,2, Makoto Demura1,2, Takashi Kikukawa1,2(1Grad. Sch. Life Sci., Hokkaido Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)– S191 –3Pos223

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光駆動イオントランスポーターハロロドプシンの理論的研究
Theoretical study on molecular mechanism of a light-driven ion transport of Halorhodopsin
Tomo Ejiri, Ryo Oyama, Shigehiko Hayashi (Grad. Sch. Sci., Univ. Kyoto)
低温ラマン分光法による光駆動 Cl-ポンプ NMR3 の発色団構造変化の研究
Low-temperature Raman study of chromophore structural changes in a light-driven Cl- pump
NMR3
Natsuki Ejima1, Tomotsumi Fujisawa1, Takashi Kikukawa2, Masashi Unno1 (1Fac. Sci. Eng., Saga
Univ., 2Fac. Adv. Life Sci., Hokkaido Univ.)
異なるプロトン化状態のアニオンチャネルロドプシン GtACR1 とその変異体の吸収波長に関する理論的研究
Theoretical study on absorption wavelengths of anion channelrhodopsin GtACR1 in different
protonation states and their mutants
Takafumi Shikakura, Cheng Cheng, Shigehiko Hayashi (Grad. Sch. Sci., Kyoto Univ.)
新奇酵素ロドプシン(NeoR)の特異な光化学特性
Unique photochemical properties of novel enzyme rhodopsin (NeoR)
Masahiro Sugiura1, Kota Katayama1, Leonid S. Brown2, Satoshi Tsunoda1, Hideki Kandori1 (1Grad.
Shc. Eng., Nagoya Inst. of Tech., 2Dept. of Phys., Univ. of Guelph)
近赤外光吸収型ロドプシンの波長制御機構
Color tuning mechanism of near-infrared light absorbing rhodopsins
Kazuki Ishikawa1, Shoko Hososhima1, Masahiro Sugiura1, Leonid S. Brown2, Satoshi Tsunoda1,
Hideki Kandori1 (1Grad. Sch. Eng., Nagoya Inst. Tech., 2Dept. Phys., Univ. Guelph)
表面増強赤外分光法を用いた Heliorhodopsin の O 中間体構造変化解析
Structural change upon O intermediate formation of Heliorhodopsin analyzed by using SEIRA
spectroscopy
Soichiro Kato1, Jingyi Tang1, Insyeerah Binti Muhammad Jauhari2, Hideki Kandori1,3, Yuji Furutani1,3(1Graduate School of Engineering, Nagoya Institute of Technology, 2Nagoya Institute of Technology,
3OptoBio, Nagoya Institute of Technology)

光生物：光合成／Photobiology: Photosynthesis
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ヘリオバクテリア反応中心における Chl-aF から BChl-g への励起エネルギー移動速度の理論的解析
Theoretical analysis of rate of excitation energy transfer from Chl-aF to BChl-g in heliobacterial
reaction center
Wataru Shimooka1, Akihiro Kimura1, Hirotaka Kitoh2, Shigeru Itoh1 (1Grad. Sch., Nagoya Univ., 2Fac.
Sci. and Engi., Kindai Univ.)
ヘリオバクテリアにおける cyt bc 複合体から光合成反応中心への電子伝達反応の分子機構
Molecular mechanism of the electron transfer reaction from cyt bc complex to thephotosynthetic reaction center in heliobacteria
Hirozo Oh-oka1,2, Hiraku Kishimoto2, Yuki Makino2, Risa Kojim1, Akihiro Kawamoto3,
Hideaki Tanaka3, Genji Kurisu3 (1CELAS, Osaka Univ., 2Grad. Sch. Sci., Osaka Univ., 3Inst. Protein Res.,
Osaka Univ.)
緑色光合成硫黄細菌における Rieske/cytb 複合体と c 型シトクロムとの構造機能相関
Structure-function relationships between the Rieske/cytb complex and c-type cytochromes inphotosynthetic green sulfur bacteria
Hiraku Kishimoto1, Ryoga Kawanami1, Chihiro Azai2, Risa Mutoh3, Hideaki Tanaka4,
Yohei Miyanoiri4, Genji Kurisu4, Hirozo Oh-oka1 (1Grad. Sch. Sci., Osaka Univ., 2Col. Life Sci.,
Ritsumeikan Univ., 3Fac. Sci., Toho Univ., 4Inst. Protein Res., Osaka Univ.)– S192 –3Pos232

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低温顕微鏡による藻類細胞内光捕集調節機構の空間・波長・時間分解解析
Study on light-harvesting regulation mechanism in algal cells by space-wavelength-timeresolved analysis by cryogenic microscope
Yuki Fujita, XianJun Zhang, Shen Ye, Yutaka Shibata (Grad. Sch. Sci., Tohoku Univ.)
紅色光合成細菌の辺縁アンテナタンパク質の B800 バクテリオクロロフィル a の改変：色素酸化と色素置換Conversion of B800 bacteriochlorophyll a in peripheral antenna proteins of purple
photosynthetic bacteria by oxidation and reconstitution
Yoshitaka Saga, Kohei Hamanishi, Yuji Otsuka, Madoka Yamashita (Fac. Sci. Eng., Kindai Univ.)
タンパク質間相互作用による光合成集光システムの調節
Regulation of light-harvesting systems by protein-protein interactions in plants
Eunchul Kim, Jun Minagawa (National Institute for Basic Biology)
紅藻 Porphyridium purpureum のフィコビリソームロッドにおける最低第 1 励起状態をもつ発色団の特定Identification of chromophores with the lowest first excited state in the phycobilisomal rod of the
red alga Porphyridium purpureum
Hiroto Kikuchi (Dept. of Phys. Nippon Med. Sch.)
太古岩石試料中の光合成色素の顕微分光分析
Microspectroscopic analysis of photosynthetic pigments in ancient rock samples
Tomohiro Ishikawa1, Ryosuke Saito2, Toru Kondo1 (1Dept. of Life Sci. and Tech. Tokyo Tech., 2Dept. ofEarth Sci., Yamaguchi Univ.)
反復回分培養による紅色非硫黄細菌の光合成を利用した水素生成能について
Photosynthetic hydrogen production performance of purple non-sulfur bacteria in repeatedbatch culture
Masahiro Hibino, Sota Suzuki (Div. Sust. Enviro. Eng., Muroran Inst. Tech.)

光生物：光遺伝学・光制御／Photobiology: Optogenetics & Optical Control
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Photo-control Small GTPase Ras Using Photochromic Peptide inhibitor
Nobuyuki Nishibe, Yuichi Imamura, Kazunori Kondo, Shinsaku Maruta (Department of Bioinformatics,
Soka University Graduate School of Engineering, Hachioji, Japan)
陸生アクチノバクテリア由来の新規微生物ロドプシン群
A novel clade of microbial rhodopsins in terrestrial Actinobacteria
Mako Ueno1, Fumio Hayashi2, Takashi Kikukawa3, Masashi Sonoyama1,4,5 (1Grad. Sch. Sci. Tech.,Gunma Univ., 2Ctr. Inst. Anal., Gunma Univ., 3Fac. Adv. Life Sci., Hokkaido Univ., 4GIAR, Gunma Univ.,
5GUCFW, Gunma Univ.)
Gs 共役型オプシンを用いた二状態安定型光操作ツールの作製
Development of bistable optical control tools based on a Gs-coupled opsin
Akinari Sakayori1, Yusuke Sakai2, Mitsumasa Koyanagi2, Akihisa Terakita2, Hisao Tsukamoto1(1Department of Biology, Kobe University, 2Department of Biology, Osaka Metropolitan University)
光活性化転写因子「光ジッパー」の分子機構
Molecular mechanism of a light-activatable transcription factor, Photozipper
Osamu Hisatomi, Yuta Nagano, Yumiko Adachi (Grad. Sch. of Sci., Osaka Univ.)
高速原子間力顕微鏡による光制御型転写因子 Photozipper の二量体形成過程の観察
Dimerization processes of a light-regulated transcription factor, Photozipper, observed by highspeed atomic force microscopy
Akihiro Tsuji1, Hayato Yamashita1, Osamu Hisatomi2, Masayuki Abe1 (1Grad. Sch. Eng. Sci., Osaka
Univ., 2Grad.Sch. Sci., Osaka Univ.)– S193 –3Pos243

光受容タンパク質を用いた液液相分離の光制御システムの作製
Creation of a light-control system for liquid-liquid phase separation using a photoreceptor protein
Mizuki Takasugi1, Yoichi Yamazaki1, Kento Yonezawa1,2, Sachiko Toma-Fukai1, Hironari Kamikubo1,2(1NAIST, MS, 2NAIST, CDG)

放射線生物／活性酸素／Radiobiology & Active oxygen
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集束超音波による生体分子への影響
Focused ultrasound induced denaturation of biomolecules
Takumi Akiu1, Kotarou Takeda2, Wakako Hiraoka1 (1Grad. Sch. Sci. & Tech., Meiji Univ., 2Sch. Sci. &Tech., Meiji Univ.)
Elucidation of intracellular temperature changes induced by external stress using fluorescentnano diamonds
Kiichi Kaminaga, Chihiro Suzuki, Yanagi Tamami, Hiroshi Abe, Takeshi Ohshima, Ryuji Igarashi(Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, QST)
ヒトプリオンタンパク質オクタリピート領域におけるレドックス調節
Redox regulation in octarepeat region of human prion protein
Wakako Hiraoka1, Osamu Inanami2, Satoru Tsuri3 (1Grad. Sch. Sci. & Tech., Meiji Univ., 2Grad. Sch.
Vet. Med., Hokkaido Univ., 3Sch. Sci. & Tech., Meiji Univ.)

生命の起源・進化／Origin of life & Evolution
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Coexistence of crystals and membraneless polyester microdroplets in a primitive complex
systemChen Chen1, Ruiqin Yi1, Motoko Igisu2, Afrin Rehana1, Takazo Shibuya2, Yuichiro Ueno2,3,Anna Wang4, Andre Antunes5, Kuhan Chandru6, Tony Z. Jia1,7 (1Earth-Life Science Institute, Tokyo
Institute of Technology, Japan, 2Institute for Extra-cutting-edge Science and Technology Avant-garde
Research (X-star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Japan,
3Department of Earth Science and Planetary Sciences, Tokyo Institute of Technology, Japan, 4School ofChemistry, UNSW Sydney, Australia, 5State Key Laboratory of Lunar and Planetary Sciences, Macau
University of Science and Technology, China, 6Space Science Center (ANGKASA), Institute of Climate
Change, Level3, Research Complex, National University of Malaysia (UKM), Malaysia, 7Blue Marble
Space Institute of Science, USA)
Exploring ancient origins of the circadian clock system through molecular evolution
Atsushi Mukaiyama1,2, Yoshihiko Furuike1,2, Shuji Akiyama1,2 (1Inst. for Mol. Sci. CIMoS,
2SOKENDAI)
Development of a translational field in the artificial cell by the shell of multiphase droplets
Kanji Tomohara, Yoshihiro Minagawa, Hiroyuki Noji (Dept. Appl. Chem., Grad. Sch. Eng., Univ.
Tokyo)
アミノ酸熱重合物を用いた代謝様反応
Metabolism-like reactions using proteinoid
Shunsuke Ito1, Shigeru Sakurazawa2 (1Future University Hakodate, 2Department of Complex andIntelligent Systems, Future University Hakodate)
触媒反応ネットワークにおけるコンパートメントの進化的獲得
Catalytic reaction networks evolve compartmentalization and compartment-specific reactions
Shunsuke Ichii1, Yusuke Himeoka1, Chikara Furusawa1,2 (1Grad. Sch. Sci., Univ. of Tokyo, 2BDR,
RIKEN)– S194 –3Pos252

緩慢凍結融解サイクルによるベシクル融合実験：原始細胞生成過程への示唆
Vesicle fusion via slow freeze-thaw cycles and its implications for the emergence of a protocell
Natsumi Noda1, Tatsuya Shinoda1, Kazumu Kaneko1, Yoshikazu Tanaka2, Yasuhito Sekine1,
Tomoaki Matsuura1 (1ELSI, Tokyo Tech., 2Grad. Sch. Life Sci., Tohoku Univ.)

ゲノム生物学：ゲノム構造／Genome biology: Genome structure
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核スペックルの構造形成・動態のシミュレーション
Simulations of structural dynamics of nuclear speckle
Shingo Wakao, Masashi Fuji, Akinori Awazu (Graduate School of Integrated Sciences for Life, Univ.
Hiroshima)
Hi-C データからの直感的なヘテロクロマチンとユークロマチンの識別法
An intuitive discrimination method of heterochromatin and euchromatin from Hi-C data
Takashi Sumikama1,2, Takeshi Fukuma2 (1JST, PRESTO, 2WPI-NanoLSI, Kanazawa Univ.)
Modeling heterogeneous chromatin structure ensembles using metainference from Hi-C data
Chenyang Gu, Giovanni Brandani (Grad. Sch. Sci., Univ. Kyoto)

生命情報科学：構造ゲノミクス／Bioinformatics: Structural genomics
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改良 MSA を用いたアブラナ科植物の SRK/SP11 複合体構造のハプロタイプ網羅的な予測
Haplotype exhaustive prediction of SRK/SP11 complex structure in Brassicaceae using amodified MSA
Tomoki Sawa1, Yoshitaka Moriwaki1, Tohru Terada1, Kohji Murase2, Seiji Takayama2, Kentaro Shimizu1(1Dept. of Biotechnol., Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo, 2Dept. of Appl. Biol. Chem.,
Grad. Sch. of Agri. and Life Sci., Univ. of Tokyo)
深層学習を用いた、電子顕微鏡画像からの骨格筋小胞形態判別
Skeletal muscle vesicle morphology discrimination from electron microscope images using deeplearning method
Natsuki Kezuka1, Shiho Kasaya1, Kenji Etchuya1, Jun Nakamura3, Chikara Sato2, Makiko Suwa1,2(1Aoyamagakuin Univ. Sci. and Eng., 2Grad. Sch., Sci. and Eng., Aoyamagakuin Univ., 3Health andMedical Res. Inst., AIST.)
新しいタンパク質立体構造がミスセンスバリアントの評価に与える影響の評価
Evaluating the impact of new three-dimensional structures for interpretation of missense
variants in human genome
Matsuyuki Shirota1,2, Kengo Kinoshita2,3 (1Grad. Sch. Med., Tohoku Univ, 2ToMMo, Tohoku Univ,
3Grad. Sch. Inform. Sci., Tohoku Univ)
Structural characteristics of coregulated phosphorylation sites
Hafumi Nishi1,2,3 (1Grad. Sch. Info. Sci., Tohoku Univ., 2Fac. Core Res., Ochanomizu Univ., 3ToMMo,
Tohoku Univ.)– S195 –生命情報科学：機能ゲノミクス／Bioinformatics: Functional genomics
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微生物群集は普遍的に極めて安定な形質組成を持つ
Microbial communities are universally characterized by extremely stable trait compositions
Takao K Suzuki1, Motomu Matsui1, Susumu Morigasaki2, Iwao Ohtsu2, Yuki Doi2, Hisayoshi Hayashi3,
Naoki Takaya4, Wataru Iwasaki1 (1Graduate School of Frontier Sciences, the University of Tokyo,
2School of Life and Environmental Science, University of Tsukuba, 3Tsukuba-Plant Innovation ResearchCenter, University of Tsukuba, 4Microbiology Research Center for Sustainability, University of Tsukuba)
乳腺組織のがん化により染色体内相互作用を維持する遺伝子の遺伝子オントロジーの特定
Identification of gene ontologies of genes with intra-chromosomal interactions in the breast
cancer tissue
Yuta Shintani (Fac. Adv. Math. Sci., Meiji Univ)
出芽酵母プロテオームからの新規 PLP 結合タンパク質の予測
Prediction of novel PLP-binding proteins from budding yeast proteome
Masafumi Shionyu1, Momoka Nakamoto1, Atsushi Hijikata2, Yukio Mukai1 (1Grad. Sch. Biosci.,
Nagahama Inst. Bio-Sci. Tech., 2Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)

数理生物学／Mathematical biology
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膜タンパク質クラスター形成とそのシグナル伝達系における機能的意義に関する数理的研究
A Mathematical study for membrane protein cluster formations and its functional significancein signal transduction systems
Hiroaki Takagi (Sch. Med., Nara Med. Univ.)
主成分分析を用いた希少/遺伝性疾患に対する human phenotype ontology からの特徴抽出
Feature extraction from human phenotype ontology for rare/hereditary disease using principal
component analysis
Yoshino Jibiki1, Toyofumi Fujiwara2, Takanori Sasaki1 (1Fac. Adv. Math. Sci., Meiji Univ., 2DBCLS)
クロマチンポリマーモデルにおける結合分子によるクラスターの寿命
Lifetime of Bridging Induced Cluster in Chromatin Polymer Model
Ryo Nakanishi1, Koji Hukushima1,2 (1Graduate School of Arts and Sciences, The University of Tokyo,
2Komaba Institute for Science)
遺伝子発現制御ネットワークモデルの応答ダイナミクス次元圧縮
Dimensional compression of response dynamics on a gene regulatory network model
Masayo Inoue1, Kunihiko Kaneko2 (1Grad. Sch. Eng., Kyushu Inst. Tech., 2Niels Bohr Inst.)
細胞配置替え過程におけるアクトミオシンケーブルの剥離と接着の数理モデル
Mathematical model for detachment and attachment of cortical actin cable in cell rearrangement
Shuji Ishihara1,2, Keisuke Ikawa3, Kaoru Sugimura2,4 (1Grad. Sch. Arts. Sci., Univ. Tokyo, 2UBI, Univ.
Tokyo, 3Grad. Sch. Sci., Nagoya Univ., 4Grad. Sch. Sci., Univ. Tokyo)
Which asymmetry leads to genitalia rotation: Direction-dependent interfacial tension vs effective
cellular torque
Sonja Tarama1,2, Sayaka Sekine3, Erina Kuranaga3, Tatsuo Shibata2 (1Col Life Sci, Ritsumeikan Univ,
2Riken BDR, 3Grad Sch Life Sci, Tohoku Univ)
生態・進化ダイナミクスにおける一般的な速度制限
General constraint on speeds in ecological and evolutionary dynamics
Kyosuke Adachi1,2, Ryosuke Iritani2,4, Ryusuke Hamazaki2,3 (1RIKEN BDR, 2RIKEN iTHEMS, 3RIKEN
CPR, 4Grad. Sch. Sci., Univ. Tokyo)– S196 –3Pos270

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ヒト血中インスリンによるアミノ酸および脂質代謝制御機構のモデルベース同定
Model-based identification of the regulation of amino acid and lipid metabolism by insulin inhuman blood
Suguru Fujita1, Yasuaki Karasawa2, Ken-ichi Hironaka1, Akiyoshi Hirayama3, Tomoyoshi Soga3,
Shinya Kuroda1 (1Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo., 2Dept. of Neur., Grad. Sch. ofMed., Univ. of Tokyo., 3Inst. for Adv. Biosci., Keio Univ.)
ネットワーク解析に基づく乳がんのバイオマーカー予測
Biomarker prediction of breast cancer based on network analysis
Saito Torii (Fac. Adv. Math. Sci., Meiji Univ.)

非平衡・生体リズム／Nonequilibrium state & Biological rhythm
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A general approach to chemical thermodynamics and constraints for growing systems
Yuki Sughiyama, Atsushi Kamimura, Dimitri Loutchko, Tetsuya J. Kobayashi (IIS, The University ofTokyo)
動物の老化に伴う活動速度の指数減衰とトランスポゾン駆動老化仮説の検証
Exponential decline of C. elegans behavioral activity along with aging and experimental test of
the transposon-driven aging hypothesis
Yukinobu Arata, Jurica Peter, Sako Yasushi (RIKEN, CPR, Cell Info)
Overpotential Estimation in Enzymatic Reactions of Mitochondrial Respiratory Chains
Nuning Anugrah Putri Namari1, Kotaro Takeyasu2,3, Junji Nakamura3,4 (1Graduate School of Scienceand Technology, University of Tsukuba, 2Department of Materials Science, Faculty of Pure and Applied
Sciences, University of Tsukuba, 3Tsukuba Research Center for Energy Materials Science, University ofTsukuba, 4Mitsui Chemicals, Inc.-Carbon Neutral Research Center, International Institute for CarbonNeutral Energy Research, Kyushu University)
細胞内微小管の物理的性質
Probing physical properties of intracellular microtubules
Ryota Ori, Hirokazu Tanimoto (Grad. Sch. Nanobioscience., Univ. Yokohama City)

計測／Measurements
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磁気刺激による細胞活動制御のための磁気レシーバー・磁気刺激システムの開発
Development of novel technique for magnetic activation of living-cell functions
Shunki Takaramoto1, Hiromu Yawo1, Yujiro Nagasaka1, Hikaru Yoshioka2, Masaki Sekino2,
Keiichi Inoue1 (1ISSP Univ. Tokyo, 2Sch. Eng., Univ. Tokyo)(2SGA-3) Decoding single-cell transcriptomic phenotypes from cell images enabled by robotic
data acquisition and deep learning
Jianshi Jin1, Taisaku Ogawa1, Nozomi Hojo1, Kirill Kryukov2, Kenji Shimizu3, Tomokatsu Ikawa4,
Tadashi Imanishi2, Taku Okazaki3, Shiroguchi Katsuyuki1 (1BDR, RIKEN, 2Dept. of Mol. Life Sci., Tokai
Univ. Sch. of Med., 3Inst. for Quant. Biosci., Univ. of Tokyo, 4Res. Inst. for Biomed. Sci., Tokyo Univ. of
Sci.)
Plunus Lanessiana から抽出した蛍光色素の解析と水素化アモルファスシリコン薄膜上での特性
Characterization of fluorescent pigment extracted from Plunus Lanessiana and the properties
on hydrogenated amorphous silicon film
Kazunori Takada1, Mao Izumi1, Satomi Kimura1, Koyu Akiyama1, Hiroshi Masumoto2,
Yutaka Tsujiuchi1,2 (1Material Science and Engineering, Akita University, 2Frontier Research Institutefor Interdisciplinary Sciences, Tohoku University)– S197 –3Pos279

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3Pos290センサシステム研究のための水素化アモルファスシリコンで増強された脂肪酸とクマリンの複合分子薄膜
Composite molecular film of fatty acid and coumarin for sensor system enhanced byhydrogenated amorphous silicon
Koyu Akiyama1, Kazunori Takada1, Hiroshi Masumoto2, Yutaka Tsujiuchi1,2 (1Material Science andEngineering, Akita University, 2Frontier Research Institute for Interdisciplinary Sciences, Tohoku
University)
光退色後蛍光寿命回復法の開発と応用
Fluorescence Lifetime Recovery After Photobleaching (FLRAP): Concept and application
Ikumi Mori, Miyuki Sakaguchi, Shoichi Yamaguchi, Takuhiro Otosu (Grad. Sch. Sci. Eng. Saitama
Univ.)
光ファイバ型蛍光相関分光装置の開発と性能評価
Development of a fiber-optic based fluorescence correlation spectroscopy and its performance
evaluation
Johtaro Yamamoto1, Akira Sasaki2 (1Health & Med. Res. Inst., AIST, 2Biomed. Res. Inst., AIST)
Measuring the heat flux of intracellular reactions using differential scanning calorimetry
Tasuku Sato1, Akira Murakami1, Kohki Okabe1,2, Takashi Funatsu1 (1Graduate School of
Pharmaceutical Sciences, The University of Tokyo, 2PRESTO, JST)
Measurement of the physical properties in a cell with optical method
Yasuhiro Maeda1, Sonja Tarama2, Mitsusuke Tarama2, Junichi Kaneshiro1, Tatsuo Shibata2,
Tomonobu Watanabe1 (1Laboratory for Comprehensive Bioimaging , RIKEN BDR, 2Laboratory for
Physical Biology, RIKEN BDR)
ゼブラフィッシュ心臓における細胞外マトリックスの弾性率の AFM 測定と細胞運命制御機構
AFM analysis of the stiffness of extracellular matrix of zebrafish heart and its contribution tocell fate determination
Sho Matsuki, Ryuta Watanabe, Yuuta Moriyama, Toshiyuki Mitsui (Grad. Sch. Sci., Univ. Aogaku)High-Speed AFM revealed dynamic behavior of antibody
Norito Kotani, Takashi Morii, Takao Okada (Research Institute of Biomolecule Metrology Co.,Ltd.)
シロザケ椎骨の骨質解析
Assessment of Bone Quality in Chum Salmon Vertebrae
Shota Hironaka, Chihiro Kawamoto, Humiya Nakamura, Hiromi Kimura-Suda (Graduate School of
Science and Engineering, Chitose Institute of Science and Technology)
Application of a bench-top NMR instrument for omics studies of gut microbiota metabolites
Zihao Song1, Yuki Ohnishi1, Seiji Osada2, Li Gan1, Jiaxi Jiang1, Zhiyan Hu1, Hiroyuki Kumeta1,
Yasuhiro Kumaki1, Kiminori Nakamura1, Tokiyoshi Ayabe1, Kazuo Yamauchi3, Tomoyasu Aizawa1(1Grad. Sch. Life Sci., Hokkaido Univ., 2Nakayama Co.,Ltd., 3IAS, OIST)
Research on metabolomics of human breast milk samples by benchtop NMR and high field NMR
Zhiyan Hu1, Jiaxi Jiang1, Li Gan1, Zihao Song1, Yuki Ohnishi1, Seiji Osada2, Hiroyuki Kumeta1,
Yasuhiro Kumaki1, Kazuo Yamauchi3, Tomoyasu Aizawa1 (1Grad. Sch. Life Sci., Hokkaido Univ.,
2Nakayama Co.,Ltd., 3IAS, OIST)
大腸菌一遺伝子欠損株におけるラマンスペクトルとオミクスデータの対応
Correspondence between Raman spectra and omics data in E. coli single gene deletion strains
Genta Chiba1, Ken-ichiro Kamei2, Arisa Oda2,3, Kunihiro Ohta2,3, Yuichi Wakamoto2,3 (1Dept. Integ.
Sci., Univ. Tokyo, 2Grad. Sch. Art Sci., Univ. Tokyo, 3UBI, Univ. Tokyo)
アクチン繊維の QCM 測定における独特の周波数シフト
Unique frequency-shifts in QCM measurement on binding biomolecules having filamentous
shape
Naoki Matsumoto1, Honoka Kobayashi2, Taiki Nishimura1, Yuki Sakurai1, Kaito Kobayashi1,
Kaho Yokomuro1, Kazuya Soda1, Ikuko Fujiwara2, Hajime Honda2 (1Dept. of Bioeng. Nagaoka Univ. of
Tech., 2Dept. of Matl. Sci. and Bioeng., Nagaoka Univ. of Tech.)– S198 –3Pos291

交流電場による細胞の回転運動を利用した，非標識に細胞の誘電特性を計測する電極デバイスの開発
Development of Simultaneous Electrorotation Device with Microwells for Non-Labeled
Characterization of Cellular Dielectric Properties
Masato Suzuki1, Mio Tsuruta1, Shee Chean Fei2, Seiichi Uchida2, Tomoyuki Yasukawa1 (1Grad. Sch.
Sci., Univ. Hyogo, 2Grad. Sch. Info. Sci. Elect. Eng., Kyushu Univ.)

バイオイメージング／Bioimaging
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RNA ポリメラーゼによる転写開始素過程の一分子解析
Probing processes in transcription initiation by Escherichia coli RNA polymerase using singlemolecule methods
Shingo Fukuda, Toshio Ando (WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University)
水中測定におけるサブミクロン分解能赤外分析法（O-PTIR）の汎用性拡大に向けた検討
Expanding the versatility of sub-micron resolution infrared analysis method (O-PTIR) in
underwater measurement
Naoki Baden (Nihon Thermal Consulting, Co., Ltd.)
Importance of annexin V N-terminal for 2D crystal formation revealed by HS-AFM
Trang Ngoc Tran1, Ryusei Yamada2, Holger Flechsig3, Toshiki Takeda4, Noriyuki Kodera3,
Hiroki Konno3 (1Graduate School of Frontier Science Initiative, Kanazawa University, Kakuma-machi,
Kanazawa 920-1192, Japan, 2Graduate School of Natural Science & Technology, Kanazawa University,
Kanazawa 920-1192, Japan, 3WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University,
Kakuma-machi, Kanazawa 920-1192, Japan, 4College of Science and Engineering, School of Natural
system, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan)
蛍光タンパク質型高感度温度センサーを用いた小胞体での微小な熱発生計測
Extremely sensitive measurement of thermogenesis in the endoplasmic reticulum using a
FRET-based thermosensor with huge dynamic range
Shun-ichi Fukushima, Takeharu Nagai (SANKEN, Univ. Osaka)
超広視野顕微鏡の安価版(SeMATERAS)の開発
Inexpensive development of ultra-wide-field microscope SeMATERAS
Masashi Ohmach, Hiromichi Wakebe, Yuichi Inoue (SIGMA KOKI Co.,LTD.)
Protein Unfolding Dynamics during Translocation through a Solid-state Nanopore
Hirohito Yamazaki, Sotaro Uemura (The University of Tokyo, Department of Biological Science)
チラコイド膜中に存在する光化学系 II 超複合体の高速 AFM による可視化
Visualization of photosystem II super complex in thylakoid membrane by HS-AFM
Daisuke Yamamoto (Fac. Sci., Fukuoka Univ.)
Nanoscale visualization of cell membrane exposed to non-thermal atmospheric pressureplasmaHan Gia Nguyen1, Linhao Sun2, Tatsuya Kitazaki3, Shinya Kumagai3, Shinji Watanabe2 (1Grad. Sch.
Nano Life Sci., Univ. Kanazawa, 2WPI NanoLSI, Univ. Kanazawa, 3Univ. Meijo)
ナノレベルの精度を持つ光電子相関顕微鏡の要素開発：無冷媒クライオスタットを用いたサン
プルホルダーのサブミリケルビン安定化
Sub-milliKelvin stabilization of sample holders with closed-cycle cryostat for correlative light andelectron microscopy with nm accuracy
Takuma Yorita, Michio Matsushita, Satoru Fujiyoshi (Department of Physics,Tokyo Institute ofTechnology)– S199 –3Pos301

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3Pos308(2SBA-6) 細胞内の一分子を三次元でナノレベルの分解能で観察できる「クライオ三次元ナノス
コピー」の開発(2SBA-6) Cryo-3D Nanoscopy to localize three-dimensional position of individual fluorophorewith nanometer precision in the cell
Kanta Naruse1, Tsuyoshi Matsuda1, Yuta Mizouchi1, Takeshi Shimi2, Hiroshi Kimura2, Eiji Nakata3,
Takashi Morii3, Michio Matsushita1, Satoru Fujiyoshi1 (1Department of physics, Tokyo institute oftechnology, 2Cell Biology Center, Institute of Innovative Research, Tokyo institute of technology,
3Institute of Advanced Energy, Kyoto University)
SARS-CoV-2 スパイク（S）タンパク質の時空間追跡と ACE2 受容体および小さな細胞外小胞との相互作用
Spatiotemporal tracking of SARS-CoV-2 spike (S) protein and its interaction with ACE2 receptor
and small extracellular vesicles
KeeSiang Lim1, Goro Nishide2, Takeshi Yoshida4, Takahiro Watanabe-Nakayama1, Akiko Kobayashi3,
Masaharu Hazawa1,3, Rikinari Hanayama1,4, Toshio Ando1, Richard W. Wong1,3 (1Kanazawa University.,
WPI-Nano Life Science Institute, 2Kanazawa University., Division of Nano Life Science in the Graduate
School of Frontier Science Initiative, WISE Program for Nano-Precision Medicine, Science andTechnology, 3Kanazawa University., Cell-Bionomics Research Unit, Institute for Frontier Science
Initiative (INFINITI), 4Kanazawa University., Department of Immunology, Graduate School of Medical
Sciences.)
細胞内一分子ナノスコピーのための近赤外蛍光標識技術の開発
Near-infrared fluorescent labeling technique for cryogenic single molecule nanoscopy in cellKazuki Kuramoto1, Kei Muto2, Ryuya Miyazaki2, Junichiro Yamaguchi2, Kanta Naruse1,
Naoki Kamiya1, Hidekazu Aramaki1, Michio Matsushita1, Haruka Oda3,4, Takeshi Shimi3,4,
Hiroshi Kimura3,4, Satoru Fujiyoshi1 (1Department of Physics, Tokyo Institute of Technology,
2Department of Applied Chemistry, Waseda University,, 3Bioscience and Biotechnology, Tokyo Institute ofTechnology, 4Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology,)
局在化する高分散化表面修飾ナノダイヤモンドの開発とその細胞移行に関する研究
Research on the development of localized highly dispersed surface modified nanodiamond andtheir cellular uptake
Hirotaka Okita1, Shingo Sotoma1, Shunsuke Chuma1,2, Madoka Suzuki1, Yoshie Harada1,3 (1IPR.,
Osaka Univ., 2Grad. Sch. Sic., Osaka Univ., 3QIQB., Osaka Univ.)(2SBA-5) High-resolution mapping of chromatin compaction and dynamics in live cells by labelfree interference microscopy
Yi-Teng Hsiao, Chia-Ni Tsai, Fasih Bintang Ilhami, Chia-Lung Hsieh (Institute of Atomic and Molecular
Sciences (IAMS), Academia Sinica / Taiwan)
A new technique for detecting single biomolecule fluctuations using surface distancedependent spectral changes in the QD emission
Kaoru Okura, Hitoshi Tatsumi (Department of Applied Bioscience, Kanazawa Inst. of Technol.,
Ishikawa, Japan)
Gaussian Weighted Background Correction For Raman images with application to hydrogel
samples
Jean-Emmanuel Clement (Institute for Chemical Reaction Design and Discovery (ICReDD), Hokkaido
University)
一分子イメージングを用いた生細胞内 RNA ポリメラーゼⅡの様々な転写サイクル段階におけるダイナミクス解析
RNA Polymerase II dynamics analysis at different stages of the transcription cycle in living cells
using single-molecule imaging
Ryo Akita, Yuma Ito, Makio Tokunaga (Sch. Life Sci. Tech., Tokyo Inst. Tech.)– S200 –3Pos309

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A green color fluorescence lifetime-based biosensor for quantitative imaging of intracellular ATP
in multicellular system
Cong Quang Vu1, Taketoshi Kiya2, Toshinori Fujie3, Tetsuya Kitaguchi4, Satoshi Arai1 (1Grad. Sch.
NanoLS., Kanazawa Univ., 2Grad. Sch. of Nat. Sci. Tech., Kanazawa Univ., 3Sch. of Life Sci. and Tech.,Tokyo Tech., 4Inst. of Inno. Res., Tokyo Tech.)
膜受容体と脂質ドメインの共クラスター化を評価するための 3 色 SMLM 解析ワークフロー
Workflows of triple-color single-molecule localization microscopy analysis to assess coclustering of membrane receptors and lipid domains
Masataka Yanagawa1,2, Mitsuhiro Abe1, Yasushi Sako1 (1Riken CPR, 2JST PRESTO)
NIR-triggered vesicles to manipulate spatial and temporal dynamics of a neurotransmitter inskeletal muscle and Drosophila brain
Takeru Yamazaki1, Satya Sarker1, Taketoshi Kiya2, Satoshi Arai1 (1Grad. Sch. NanoLS., Kanazawa
Univ., 2Grad. Sch. of Nat. Sci. Tech., Kanazawa Univ)(1SEP-3) Triple-color photothermal dye-based nanoheaters to generate multiple heat spots
within a single cell
Md Monir Hossain, Takeru Yamazaki, Kayoko Nomura, Satoshi Arai (Grad. Sch. NanoLS., Kanazawa
Univ.)
可逆的ターンオン型蛍光標識技術の開発とライブセル蛍光イメージングへの応用
Development of reversible turn-on fluorescent labeling technology and its application to live
cell fluorescence imaging
Shigeyuki Namiki, Daisuke Asanuma, Hiroki Ishikawa, Shinkuro Kobayashi, Kenzo Hirose(Department of Pharmacology, Graduate school of Medicine, The University of Tokyo)

バイオエンジニアリング／Bioengineering
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DNA で作るナノミウラ折り
Nano Miura fold fabricated with DNA
Daisuke Ishikawa, Masahiko Hara (Sch. Mater. Chem. Tech., Tokyo Tech)
相分離液滴をテンプレートとした DNA オリガミカプセルの構築
Construction of DNA origami capsules using phase-separated droplets as templates
Nagi Yamashita1, Marcos Masukawa2, Mayumi Chano3, Yusuke Sato4, Masahiro Takinoue1,3(1Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute ofTechnology., 2Department of Chemistry, Johannes Gutenberg University Mainz., 3Department ofComputer Science, School of Computing, Tokyo Institute of Technology., 4Department of Systems Design
and Informatics, School of Computer Science and Systems Engineering, Kyushu Institute of Technology.)
DNA ハイドロゲルの形成と変形の光制御
Photocontrol of DNA hydrogel formation and deformation
Yoshiaki Sano1, Masahiro Takinoue1,2 (1Department of Life science and Technology, Tokyo Institute ofTechnology, Japan, 2Department of Computer Science, Tokyo Institute of Technology, Japan)
電子線照射が微生物細胞に及ぼす影響
Effects of an electron beam irradiation on living bacterial cells
Junya Katai1, Yuta Nagano1, Kenshi Suzuki2, Kazuki Yasuike1, Ryoya Hayashi1, Asahi Tanaka3,
Tetsuo Narumi1, Masaki Shintani1, Yosuke Tashiro1, Wataru Inami4, Yoshimasa Kawata4,
Fumihiro Sassa5, Hiroyuki Futamata6 (1Dept. Appl. Chem. Biological Eng., Univ. Shizuoka, 2Grad. Sch.
Scie. Tech., Univ. Shizuoka, 3Coop. Major. Med. Photo., Univ. Shizuoka., 4Res. Inst. Elect., Univ.
Shizuoka, 5Grad. Sch. Fac. Inf. Sci. Elect. Eng.,Unv. Kyushu, 6Res. Inst. Green. Sci. Tech., Univ.
Shizuoka)– S201 –その他／Miscellaneous topics
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サブテラヘルツ照射によるタンパク質および核酸の構造変化の溶液 NMR 解析
Structural changes of proteins and nucleic acids induced by sub-terahertz radiation investigatedby using solution NMR spectroscopy
Yuji Tokunaga1, Masahiko Imashimizu2, Koh Takeuchi1 (1Grad. Sch. Pharm. Sci., UTokyo, 2CMB,
AIST)
Medusavirus の局所構造解析によるウイルス粒子形成に伴う構造変化の可視化
Visualization of structural changes associated with virus particle formation by local structural
analysis of Medusavirus
Ryoto Watanabe1,2, Chihong Song1,2,3, Kazuyoshi Murata1,2,3, Masaharu Takemura4 (1National Institutefor Physiological Sciences (NIPS), 2The Graduate University for Advanced Studies (SOKENDAI), 3The
Exploratory Research Center on Life and Living Systems (ExCELLS), 4Tokyo University of Science)
人工多細胞の自動生産に関する研究
Toward automated production of lipid-based multi-compartment assemblies
Ryo Shimizu1, Richard James Archer1, Gen Hayase2, Satoshi Murata1, Shin-Ichiro Nomura1 (1Grad. Sch.
Eng., Univ. Tohoku/Japanese, 2WPI-MANA)
表面微細構造上における付着珪藻の増殖挙動
The growth of marine benthic diatoms on micro patterned surfaces
Takayuki Murosaki1, Taiki Kishigami2, Yuji Hirai3, Yasuyuki Nogata4 (1Department of Chemistry,
Asahikawa Medical University, 2Graduate School of of Science and Engineering, Chitose Institute of
Science and Technology, 3Department of Applied Chemistry and Bioscience, Faculty of Science andEngineering, Chitose Institute of Science and Technology, 4Sustainable System Research Laboratory,
Central Research Institute of Electric Power Industry)
Magnetic induced assembly of anisotropic structures for reversible lipid compartment
deformations
Richard Archer, Shinichiro M. Nomura (Tohoku University, Department of Robotics)
超撥水表面上の水滴の跳ね返り挙動に関する理論的考察
Theoretical Consideration on Bouncing Behavior of Water Droplet on Superhydrophobic
Surface
Hiroyuki Mayama (Department of Chemistry, Asahikawa Medical University)
Self-assembly of DNA origami blocks into two-dimensional crystalline structures with designed
geometries
Yuki Suzuki1, Ibuki Kawamata2 (1Grad. Sch. Eng., Mie Univ., 2Grad. Sch. Eng., Tohoku Univ.)– S202 –