Curriculum Vitae
March. 23, 2020
Name: Koji Kubota
Personal Information
Nationality: Japanese
Affiliation: 1nstitute for chemical reaction design and discovery (WPI-ICReDD),
Hokkaido University
Date of Birth: April 2, 1989
Address: WPI-ICReDD, Hokkaido University, Nishi 10, Kita 21, Kita-ku,
Sapporp, Hokkaido, 001-0021, Japan
Email: kbt@eng.hokudai.ac.jp
Phone: +81-11-706-9654
ORCiD: https://orcid.org/0000-0003-1522-291X
ResearcherID: E-6798-2017
Degree2016. Doctoral degree of Engineering, Hokkaido University
Supervisor: Prof. Hajime Ito
Education and ExperienceApril 2019 to present
Specially Appointed Assistant Professor at 1nstitute for chemical reaction designand discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan.
April 2018 to March 2019
Specially Appointed Assistant Professor at Graduate School of Engineering,
Hokkaido University, Sapporo, Japan.
April 2017 to March 2018
JSPS Postdoctoral Fellow at Massachusetts Institute of Technology, Cambridge,Massachusetts, United States (Advisor: Prof. Stephen L. Buchwald and Prof.
Bradley L. Pentelute)May 2016 to March 2017

Postdoctoral Fellow at University of California, Berkeley, California, UnitedStates (Advisor: Prof. F. Dean Toste)
October 2013 to March 2016
Ph.D. Hokkaido University, Sapporo, Japan (Ph.D. Advisor: Prof. Hajime Ito)
April 2012 to September 2013
M.Sc. Hokkaido University, Sapporo, Japan (Master Thesis; Advisor: Prof.
Hajime Ito)
January 2014 to March 2014
Visiting Researcher in Department of Chemistry, University of Alberta,
Edmonton, Canada (Advisor: Prof. Dennis G. Hall)
Research Interests
Mechanochemistry, Organic synthesis, Organometallic chemistry, Catalytic
enantioselective synthesis, Organocatalysis, Phase-transfer catalysis, Chemicalbiology,Fellowships and Awards
2019 ACP Lectureship Award (Singapore)2019 47th Naito Conference Best Poster Award
2018 Inoue Research Award for Young Scientists
2017 Lindau Nobel Laureate Meeting Fellow
2017 JSPS Overseas Research Fellowship2016 2016 Springer Thesis Award
2016 Reaxys PhD Prize 2016 Finalist
2015 2015 Pacifichem Student Competition Poster Award
2015 6th Otsu Conference Research Proposal Award
2015 6th Otsu Conference Award Fellow
2015 7th HOPE Meeting Best Presentation Award
2015 7th HOPE Meeting Fellow
2014 JSPS Research Fellowship DC1
2014 Hokkaido University Otsuka Award
2012 Hokkaido University Frontier Fellowship2012 59th Symposium of Organometallic Chemistry Best Poster Award
2012 Hokkaido University William Wheeler Prize AwardPublications
1. Akiyama, S.; Nomura, S.; Kubota, K.; Ito, H.* “Copper(I)-catalyzed boryl
substitution of 1-trifluoromethyl allenes for the synthesis of 3-borylsubstituted 1,1-gem-difluorodienes”.
J. Org. Chem. 2020, 85, 4172.

2. Hayama, K.; Kojima, R.; Kubota, K.; Ito, H.* “Synthesis of chiral Nheterocyclic

allylboronates

via

theenantioselective

borylative

dearomatization of pyrroles”.
Org. Lett. 2020, 22, 739.

3. Takahashi, R.; Kubota, K.*; Ito, H. “Air- and moisture-stable Xantphosligated palladium dialkyl complex as a precatalyst for cross-coupling
reactions”.
Chem. Commun. 2020, 56, 407.

4. Kubota, K.*; Pang, Y.; Miura, A.; Ito, H.* “Redox reactions of small organic
molecules using ball milling and piezoelectric materials”.
Science 2019, 366, 1500.

5. Seo, T.; Ishiyama, T.; Kubota, K.*; Ito, H.* “Solid-state Suzuki-Miyaura crosscoupling

reactions:olefin-accelerated

C-Ccouplingusing

mechanochemistry”.
Chem. Sci. 2019, 10, 8202.

6. Akiyama, S.; Kubota, K.; Mikus, M. S.; Paioti, P. H. S.; Romiti, F.; Liu, Q.;
Zhou, Y.; Hoveyda, A. H.*; Ito, H.* “Catalytic enantioselective synthesis ofallylic boronates bearing a trisubstituted alkenyl fluoride and relatedderivatives”.
Angew. Chem. Int. Ed. 2019, 58, 11998.

7. Iwamoto, H.; Endo, K.; Ozawa, Y.; Watanabe, Y.; Kubota, K.; Imamoto, T.;
Ito, H.* “Copper(I)-catalyzed enantioconvergent borylation of racemic benzyl

chlorides enabled by quadrant-by-quadrant structure modulation of chiralbisphosphine ligands”.
Angew. Chem. Int. Ed. 2019, 58, 11112.

8. Kubota, K.; Uesugi, M.; Osaki, S.; Ito, H.* “Synthesis of 2-alkyl-2-borylsubstituted-tetrahydrofurans via copper(I)-catalyzed borylative cyclization ofaliphatic ketones”.
Org. Biomol. Chem. 2019, 17, 5680.

9. Kubota, K.*; Takahashi, R.; Ito, H.* “Mechanochemistry allows carrying out
sensitive organometallic reactions in air: glove-box-and-Schlenk-line-freesynthesis of oxidative addition complexes from aryl halides andpalladium(0)”.
Chem. Sci. 2019, 10, 5837.

10. Pang, Y.; Ishiyama, T.; Kubota, K.*; Ito, H.* “Iridium(I)-catalyzed C-Hborylation in air by using mechanochemistry”.

Chem. Eur. J. 2019, 25, 4654.

11. Kubota, K.*; Seo, T.; Koide, K.; Hasegawa, Y.; Ito, H.* “Olefin-accelerated
solid-state C-N cross-coupling reactions using mechanochemistry”.
Nature Commun. 2019, 10, 111.

12. Ito, H.*; Seo, T.; Kojima, R.; Kubota, K. “Copper(I)-catalyzed stereoselective
defluoroborylation of aliphatic gem-difluoroalkenes”.
Chem. Lett. 2018, 47, 1330.

13. Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.*;
Toste, F. D.* “Enantioselective synthesis of N,S-acetals by an oxidative
Pummerer type transformation using phase-transfer catalysis”.
Angew. Chem. Int. Ed. 2018, 57, 589.

14. Kubota, K.; Dai, P.; Pentelute, B. L.*; Buchwald, S. L.* “Palladium oxidative
addition complexes for peptide and protein crosslinking”.
J. Am. Chem. Soc. 2018, 140, 3128.

15. Hayama, K.; Kubota, K.; Iwamoto, H.; Ito, H.* “Copper(I)-catalyzeddiastereoselective dearomative carboborylation of indoles”.
Chem. Lett. 2017, 46, 1800.

16. Iwamoto, H.; Ozawa, Y.; Kubota, K.; Ito, H.* “Copper(I)-catalyzed regio- andstereoselective intramolecular alkylboration of propargyl ethers and amines”.
J. Org. Chem. 2017, 82, 10563.

17. Kojima, R.; Kubota, K.; Ito, H.* “Stereodivergent hydrodefluorination of gemdifluoroalkenes: selective synthesis of (Z)- and (E)-monofluoroalkenes”
Chem. Commun. 2017, 53, 10688.

18. Kubota, K.; Osaki, S.; Jin, M.; Ito, H.* “Copper(I)-catalyzed enantioselective
nucleophilic borylation of ketones: synthesis of enantioenriched chiraltertiary alpha-hydroxyboronates”
Angew. Chem. Int. Ed. 2017, 56, 6646.

19. Kubota, K.; Watanabe, Y.; Ito, H.* “Synthesis of enantiomerically enrichedchiral tetrahydroquinolines via sequential dearomatization/enantioselective
borylation reactions”
Adv. Synth. Catal. 2016, 358, 2379.

20. Kubota, K.; Jin, M.; Ito, H.* “Computational insight into the enantioselective
nucleophilic borylation of a polarized C=O double bond catalyzed bydiphosphine-borylcopper(I) complexes”
Organometallics 2016, 35, 1376.

21. Kubota, K.; Watanabe, Y.; Hayama, K.; Ito, H.* “Enantioselective synthesis ofchiral piperidines via the stepwise dearomatization/borylation of pyridines”
J. Am. Chem. Soc. 2016, 138, 4338.

22. Iwamoto, H.; Kubota, K.; Ito, H.* “Highly selective Markovnikov
hydroboration of alkyl-substituted terminal alkenes with a phosphinecopper(I) catalyst”

Chem. Commun. 2016, 52, 5916.

23. Yamamoto, E.; Kojima, R.; Kubota, K.; Ito, H.* “Copper(I)-catalyzeddiastereoselective borylative exo-cyclization of alkenyl aryl ketones”
Synlett 2015, 27, 272.

24. Kubota, K.; Hayama, K.; Iwamoto, H.; Ito, H.* “Enantioselective borylative
dearomatization of indoles through copper(I) catalysis”
Angew. Chem. Int. Ed. 2015, 54, 8809.

25. Iwamoto, H.; Kubota, K.; Yamamoto, E.; Ito, H.* “Copper(I)-catalyzed
carbon-halogen bond-selective boryl substitution of alkyl halides bearing
terminal alkene moieties”
Chem. Commun. 2015, 51, 9655.

26. Sun, H.; Kubota, K.; Hall, D. G.* “Reaction optimization, scalability, andmechanistic insight on the catalytic enantioselective desymmetrization of 1,1diborylalkanes via Suzuki-Miyaura cross-coupling”
Chem. Eur. J. 2015, 21, 19186.

27. Kubota, K.; Iwamoto, H.; Yamamoto, E.; Ito, H.* “Silicon-tethered strategy forcopper(I)-catalyzed stereo- and regioselective alkylboration of alkynes”
Org. Lett. 2015, 17, 620.

28. Kubota, K.; Yamamoto, E.; Ito, H.* “Copper(I)-catalyzed enantioselective
nucleophilic borylation of aldehydes: an efficient route to enantiomericallyenriched alpha-alkoxyorganoboronate esters”
J. Am. Chem. Soc. 2015, 137, 420.

29. Kubota, K.; Yamamoto, E.; Ito, H.* “Regio- and enantioselective
monoborylation of alkenylsilanes catalyzed by an electron-donating chiral
phosphine-copper(I) complex”
Adv. Synth. Catal. 2013, 355, 420.

30. Kubota, K.; Yamamoto, E.; Ito, H.* “Copper(I)-catalyzed borylative exocyclization of alkenyl halides containing unactivated double bond”
J. Am. Chem. Soc. 2013, 135, 2635.

31. Ito, H.*; Kubota, K. “Copper(I)-catalyzed boryl substitution of unactivat
ed alkyl halides”
Org. Lett. 2012, 14, 890.

Reviews
1. Kubota, K. “Synthesis of functionalized organoboron compounds throughcopper(I) catalysis” 2017, Springer Theses, Springer
2. Kubota, K.; Ito, H. “Chapter 1- Catalytic generation of silicon nucleophiles in
Organosilicon Chemistry: Novel approaches and reactions” 2020, Eds.
Hiyama, T.; Oestreich, M., Wiley-VCH
3. Kubota, K.; Iwamoto, H.; Ito, H.* “Formal nucleophilic borylation andborylative cyclization of organic halides” Org. Biomol. Chem. 2017, 15, 285.
4. Yamamoto, E.; Takenouchi, Y.; Kubota, K.; Ito, H.* “Selective synthesis oforganoboron compounds with copper(I)-phosphine complex catalysts” J.
Synth. Org. Chem. Jpn. 2014, 72, 758.
5. Kubota, K. “Topochemical photocyclizations for the synthesis of twodimensional polymers” J. Synth. Org. Chem. Jpn. 2014, 72, 834.

References[1] Prof. Stephen L. Buchwald (Massachusetts Institute of Technology, UnitedStates) Email: sbuchwal@mit.edu[2] Prof. Bradly L. Pentelute (Massachusetts Institute of Technology, UnitedStates) Email: blp@mit.edu[3] Prof. F. Dean Toste (University of California, Berkeley, United States)
Email: fdtoste@berkeley.edu[4] Prof. Dennis G. Hall (University of Alberta, Canada)
Email: dennis.hall@ualberta.ca[5] Prof. Hajime Ito (Hokkaido University, Japan)
Email: hajito@eng.hokudai.ac.jp