⋡㩷 ᰴ㩷‫ع‬ߏ᜿ᜦ ㆮવሶ∛೙ᓮ⎇ⓥᚲ ᚲ㐳 ਄಴ ೑శ‫ع‬ㆮવሶ∛೙ᓮ⎇ⓥᚲ ⚵❱࿑‫ع‬ઍ⴫⊛⎇ⓥᬺ❣⚫੺‫ع‬ർᄢࠍㅌ⡯ߔࠆߦ޽ߚߞߡ ఺∉↢‛ಽ㊁ ᢎ᝼ ዊ㊁ᳯ ๺ೣ‫ع‬㒝ዻᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯㐿⸳ߩߏ᜿ᜦ ࠮ࡦ࠲࡯㐳 ⇗ጊ ᣽ೣ‫ع‬㒝ዻേ‛ታ㛎ᣉ⸳ ᣉ⸳㐳 ᢎ᝼ ᔒ↰ ᄈ೑‫ع‬ᣂછᢎ᝼⚫੺ ಽሶ↢૕㒐ᓮಽ㊁ ᢎ᝼ 㜟ጟ ᤩᢎ‫ع‬⎇ⓥᚲ㨀㧻㧼㧵㧯㧿2008 ᐕ 12 ᦬ No.1

ߏ ᜿ ᜦ ർᶏ㆏ᄢቇㆮવሶ∛೙ᓮ⎇ⓥᚲᚲ㐳 ਄಴ ೑శ㐳ᐕߩ ᩺ߢ޽ߞߚ⎇ⓥᚲߩᡷୃ࡮Ⴧ▽Ꮏ੐߇ቢੌߒ‫⎇ޔ‬ⓥᚲᚲዻߩฦಽ㊁‫ޔ‬㒝ዻᣉ⸳࡮࠮ࡦ࠲࡯ߩᢎ⡯ຬ‫ޔ‬ቇ↢߇৻หߦળߒߡ⎇ⓥࠍផㅴߢ߈ࠆⅣႺ߇ẋߊᢛ޿߹ߒߚ‫ޕ‬7 ᦬ߦߪ‫ޔ‬૒ષᶈ✚㐳‫ޔ‬ℂ੐‫ޔ‬ㇱዪ㐳ࠍᆎ߼‫ޔ‬ᄙߊߩ㑐ଥ⠪ߦෳ೉㗂߈‫┫ޔ‬Ꮏ␨ᔨᑼౖࠍ㐿௅ߔࠆߎߣ߇ߢ߈߹ߒߚ‫ޕ‬ ᒁߊ⛯ߊ⸥ᔨ⻠Ṷળߢߪ‫ޔ‬ጯᧄᔘਃᄢ㒋ᄢቇర✚㐳‫ޔ‬
Lewis Cantley ࡂ࡯ࡃ࡯࠼ᄢቇᢎ᝼߇‫⮎ޔ‬೷ߩ㐿⊒ߦ⥋ߞߚ㐳ᐕߩၮ␆⎇ⓥߦߟ޿ߡ⻠Ṷߐࠇ‫㉓㉑ߩߘޔ‬๧ߦ⧯ᚻ⎇ⓥ⠪ߪ㝯ੌߐࠇߡ޿߹ߒߚ‫ ޕ‬ታߪᎿ੐ᦼ㑆ਛ‫┙⁛ޔ‬ᴺੱൻᓟᦨೋߩ 5 ᐕ㑆ߩᬺ❣⹏ଔߩߚ߼ߩ⾗ᢱ૞ᚑࠍ‫↰ޔ‬ਛ৻㚍೽ᚲ㐳ߣㅴ߼ߡ߈߹ߒߚ‫≸ޕ‬ಽ㊁ߦ߅ߌࠆ⎇ⓥߢߔ߫ࠄߒ޿⎇ⓥᬺ❣ࠍ᜼ߍࠄࠇߡ߈ߚ߅ੑੱߩᢎ᝼߇ㅌ⡯ߒ‫ޔ‬ᓟછߩੱ੐ߦᤨ㑆ࠍⷐߒ‫ޔ‬ᥳߊᢎ᝼⡯߇ⓨᏨߢߒߚ‫ޔߚ߹ޕ‬Ꮏ੐ߦ઻߁⒖ォ╬ߢ‫ޔ‬⎇ⓥⅣႺߣߒߡߪᄢᄌ෩ߒ޿⁁ᴫߦ޽ࠅ߹ߒߚ߇‫⺰ޔ‬ᢥߩ⾰‫ޔ‬㊂‫ޔ‬ᢥㇱ⑼ቇ⋭╬߆ࠄߩ⎇ⓥ⾌‫ޔ‬⒳‫ߩޘ‬ᄖㇱ⾗㊄⁁ᴫࠍో૕ߣߒߡ⷗ࠆߣ‫ߩࡈ࠶࠲ࠬޔ‬㜞޿ࠕࠢ࠹ࠖࡆ࠹ࠖߪ⛽ᜬߐࠇߡ޿߹ߔ‫ߩߎޕ‬ᣂߒ޿⎇ⓥⅣႺߢ‫ޔ‬ࠬ࠲࠶ࡈ৻หߩ৻ጀߩᵴべߦᦼᓙߒ߹ߔ‫ޕ‬ ᣢߦߏᛚ⍮ߩᅤߊ‫⎇ޔ‬ⓥᚲߪ⚵❱ߩౣ✬ᚑࠍታᣉߒ‫ޔ‬ᣂߚߦ‫ޟ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯㨭ࠍ⸳⟎ߒ߹ߒߚ‫⇗ޕ‬ጊ᣽ೣᢎ᝼ࠍ࠮ࡦ࠲࡯㐳ߣߒߡᚲ⻐ࡇࡠ࡝⩶ᗵᨴߦ઻޿⊒↢ߔࠆ⢗≸߿ઁߩᖡᕈ⣲≌ߩᣂⷙ੍㒐ᴺ‫ޔ‬ᴦ≮ᴺߩ㐿⊒╬ࠍ⋡ᜰߒߡ޿߹ߔ‫ޕ‬᜗ᓙ⻠Ṷ⠪ߩ Lewis Cantley వ↢ጯᧄᔘਃవ↢ߣߎࠇߪ‫ޔ‬22 ᐕᐲ߆ࠄࠬ࠲࡯࠻ߔࠆᰴᦼਛᦼ⸘↹ࠍవขࠅߒߡ‫ޔ‬ㆮવሶ∛೙ᓮ⎇ⓥᚲ߇ᗵᨴ≸⎇ⓥߦ߅ߌࠆ࿖㓙⊛⎇ⓥ᜚ὐߦߥࠆߎߣࠍ⋡ᜰߒߡ޿߹ߔ‫ޔߦᦝޕ‬⎇ⓥᚲߪ‫ోޔ‬࿖౒ห೑↪࡮౒ห⎇ⓥ᜚ὐ⹺ቯߦะߌߡ‫ޔ‬ߘߩ↳⺧Ḱ஻ߦขࠅដ߆ߞߡ޿߹ߔ‫ޕ‬᜚ὐ⹺ቯߩ޽߆ߟ߈ߦߪ‫ޔ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯߿േ‛ᣉ⸳߇౒ห೑↪࡮౒ห⎇ⓥߩ႐ߣߒߡචಽߦᯏ⢻ߒߡ޿ߊࠃ߁ᦝߥࠆ⎇ⓥⅣႺߩᢛ஻ࠍㅴ߼ߡ޿ߊᔅⷐ߇޽ࠆߣᕁ޿߹
ߔ‫ޔߪߦ߼ߚߩߘޕ‬ቇౝߪ߽ߣࠃࠅቇᄖߩᄙߊߩᣇ‫ޘ‬ߦㆮવሶ∛೙ᓮ⎇ⓥᚲߩᵴേࠍ⍮ߞߡ޿ߚߛ߈‫ޔ‬ℂ⸃ߒߡ޿ߚߛߊᔅⷐࠍ߭ߒ߭ߒߣᗵߓߡ߅ࠅ߹ߔ‫⎇ޕ‬ⓥ
ᚲߩᵴേ⚫੺ߪ‫ߢ߹ࠇߎޔ‬ᐕ㧝࿁ߩ⎇ⓥᚲᐕႎ߅ࠃ߮
2 ᐕߦ㧝࿁ߩ⎇ⓥᚲ᭎ⷐߢⴕߥߞߡ߈߹ߒߚ‫ ޕ‬ᐕႎߪ⾗ᢱ㓸ߣ޿߁ᕈᩰ߇ᒝߊ‫ޔ‬᭎ⷐߪ࠲ࠗࡓ࡝࡯ߥᐢႎߦߪਇะ߈ߢߒߚ‫ ޕ‬ਇቯᦼߢߪ޽ࠅ߹ߔ߇‫੹ޔ‬࿁⎇ⓥᚲߩᐢႎ⹹ࠍᣂߚߦ⊒ⴕߔࠆߎߣߦ޿ߚߒ߹ߒߚ‫ޕ‬੹‫ޔ‬૗߇ㆮવሶ∛೙ᓮ⎇ⓥᚲߢ⿠ߎߞߡ޿ࠆ߆㧫ߤࠎߥ⎇ⓥᚑᨐ߇಴ߡ޿ࠆߩ߆㧫ߎࠎߥߔ߫ࠄߒ޿⧯ᚻ⎇ⓥ⠪߇ᚢജߣߒߡടࠊߞߚ㧍↰ਛ৻㚍೽ᚲ㐳ࠍਛᔃߦߒߡᐕᢙ࿁ߩ⊒ⴕࠍ੍ቯߒߡ޿߹ߔ‫⊝ ޕ‬᭽
ߩߏℂ⸃ߣߏᡰេࠍ߅㗿޿ߒߡ᜿ᜦߣ޿ߚߒ߹ߔ‫ޕ‬
ᐔᚑ 20 ᐕ 10 ᦬ 20 ᣣ       ጯᧄᔘਃవ↢ߏ⻠Ṷ

-1-≸ ࠙ ࠖ ࡞ ࠬ ಽ ㊁≸ 㑐 ㅪ ㆮ વ ሶ ಽ ㊁∛ ࿃ ⎇ ⓥ ㇱ 㐷ಽ ሶ ↢ ૕ 㒐 ᓮ ಽ ㊁⎇ⓥㇱ㐷∛ ᘒ ⎇ ⓥ ㇱ 㐷ಽሶ఺≸↢ᗵᨴ∛ಽሶ఺఺∉ಽ㊁ಽ㊁ᘒಽ㊁⣲≌ಽ㊁∉↢‛ಽ㊁∉೙ᓮಽ㊁‛ಽ ሶ 㑆 ᖱ ႎ ಽ ㊁∔ᖚ೙ᓮ⎇ⓥㇱ㐷∔ᖚࡕ࠺࡞ഃᚑಽ㊁േ㒝ዻᣉ‛ታ㛎ᣉ⸳⸳ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ࡑ࠻࡝࠶ࠢࠬࡔ࠺ࠖࠬࡦ⎇ⓥㇱ㐷ነ 㒝 ⎇ ⓥㇱ 㐷ROYCE’ஜᐽࡃࠗࠝㇱ㐷‫ع‬Osteopontin regulates development and function of invariant natural killer T cells.

Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T.
Proc Natl Acad Sci U S A. 2008 105(41):15884-15889.

‫ع‬IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.

Tajima M, Wakita D, Noguchi D, Chamoto K, Yue Z, Fugo K, Ishigame H, Iwakura Y, Kitamura H, Nishimura T.
J Exp Med. 2008 205(5):1019-1027.

‫ع‬Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.

Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, Yamada G, Azuma T, Hatakeyama
M.Proc Natl Acad Sci U S A. 2008 105(3):1003-1008.

‫ع‬Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin.

Kon, S., Ikesue, M., Kimura, C., Aoki, M., Nakayama, Y., Saito, Y., Kurotaki, D., Diao, H. Matsui, Y., Segawa, T., Maeda, M., Kojima, T., Uede, T.
J Exp Med. 2008 205(1):25-33.

‫ع‬Transbilayer Phospholipid Flipping Regulates Cdc42p Signaling during Polarized Cell Growth via Rga GTPase-Activating Proteins.

Saito, K., Fujimura-Kamada, K., Hanamatsu, H., Kato, U., Umeda, M., Kozminski, KG., Tanaka, K.
Dev Cell. 2007 13(5):743-751.

‫ع‬DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
Nature. 2007 448(7152):501-505.

‫ع‬Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity.

Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S., andHatakeyama, M.Nature. 2007 447(7142):330-333.

-2-ർᄢࠍㅌ⡯ߔࠆߦ޽ߚߞߡ఺∉↢‛ಽ㊁ ᢎ᝼ዊ㊁ᳯ ๺ೣ̌Enjoy!̍ߘߒߡ̌Do your best!̍
ㆮવሶ∛೙ᓮ⎇ⓥᚲߩᡷୃ߇ᷣߺ‫ࡈ࠶࠲ࠬోߎߣߞ߿ޔ‬߇หߓࡆ࡞ߦ౉ࠆ૕೙ߦߥߞߡ 1 ᐕ߽ߚߚߕߦᒁㅌߣߥࠆ‫ޕ‬㕙ୟߊߐ޿ᒁߞ⿧ߒࠍ 2 ᐲ๧ࠊ޿‫ߎߣߞ߿ޔ‬ᵗᑼ࠻ࠗ࡟ઃߩࡇࠞࡇࠞᐡ⥢ߦ౉ߞߡ߽‫ޔ‬෰ࠆᦼ㒢߇⋡೨ߦㄼߞߡ޿ߡߪ‫⋡ޟ‬಴ᐲߐ߽ਛߊࠄ޿ߥࠅ‫ߩޠ‬ᔃႺߢ޽ࠆ‫ߥ߁ࠃߩߎޕ‬⚛᥍ࠄߒ޿ⅣႺߢ‫⎇ߡߞߥߦ✜৻߇ࡈ࠶࠲ࠬోޔ‬ⓥ↢ᵴࠍㅍࠇࠆᓟヘߦߪ‫ޔ‬ᤚ㕖⑳ߩಽ߹ߢ㗎ᒛߞߡ߽ࠄ޿ߚ޿‫ޕ‬࿯࿾ઃ߈ࠍ◲නߦᚻ᡼ߔߥ㧍 ߿ߊߑߥቇ↢↢ᵴߦ඙ಾࠅࠍߟߌ‫ޔ‬1970 ᐕߦർᄢකቇㇱࠍතᬺ⋥ᓟ‫ޔ‬೨り‫⚿ޔ‬ᩭ⎇ⓥᚲ∛ℂㇱ㐷‫ޔ‬ᕲᏧ᫪Ꮉᢎቶߩഥᚻߦߥߞߚ‫⃻ޕ‬࿷଻ஜቇ⑼ߩ႐ᚲߦ޽ߞߚ⁛┙ᐡ⥢߆ࠄ‫ޔ‬කቇㇱർ᫟ 4,5 㓏ߦ㑆୫ࠅߩᒻߢᒁߞ⿧ߒߡᢙᐕᓟߩߎߣߢ‫ߛᧂޔ‬ᑪ‛ߪᣂߒ߆ߞߚ‫ߩߘޕ‬ᓟᣂ⸳ㇱ㐷߇ߢ߈‫ޔ‬߹ߚേ‛ᣉ⸳‫⻠ޔ‬ၴ╬‫ޘ‬ᑪߡჇߒߚ߇‫ޔ‬࿯࿾ߣ❬߇ߞߡ޿ߥ޿ᖤߒߐ‫ޔ‬ᐢ߇ࠆᣇะߪ਄ߒ߆ή޿‫ޕ‬ደ਄ࡃ࡜࠶ࠢᑪߣ߽ߤ߽‫⎇ޔ‬ⓥᚲߪ⁜㓖ൻ‫ޔ‬⠧᧎ൻߒ‫ߡߒߘޔ‬ᆌᱤᑪ▽჻᭽߇⊓႐ߒ‫ߊ߿߁ࠃޔ‬⠴㔡ᐲᦨૐߩർ᫟ᡷୃ߇ታ⃻ߒߚ‫ޕ‬వߕߪ␸⌕ߣ޿߁ߎߣߢ޽ࠈ߁‫ޕ‬⦟߈Ꮷࠍᄢಾߦ‫ޔ‬੤ᵹࠍ⛯ߌࠃ㧍ᦨೋߪ㔚㗼ߩ઀੐ߛߞߚ߇‫⇐ޔ‬ቇࠍᯏߦࡑ࠙ࠬߩ⚦⢩఺∉ቇߩ⎇ⓥߦߔߞ߆ࠅߪ߹ߞߚ‫⇐ޕ‬ቇవߩᕲᏧ R.A.Goodవ↢ߪ‫ ߦ⾨࡞ࡌ࡯ࡁޔ‬2 ᐲࡁࡒࡀ࡯࠻ߐࠇߚߣ⡞ߊ߇‫ޔ‬ㆀߦฟࠊߕ 2003 ᐕઁ⇇ߐࠇߚ‫ ߦ․ޕ‬2 ࿁⋡(1990 ᐕ) ߩᤨߪ‫ޔ‬Good వ↢ߦᢎ߃ࠍ਼߁ߚߣ⥄りߢ੔ࠊࠇߡ޿ߚ
E.D.Thomas ඳ჻߇㛽㜑⒖ᬀߢ᝼ਈߐࠇߚߩߦ‫ޔ‬ᱷᔨߥߎߣߢ޽ࠆ‫ޕ‬Good వ↢ߪ 1968 ᐕߦ਎⇇ߢೋ߼ߡ SCID ᖚఽࠍ㛽㜑⒖ᬀߢቢᴦߐߖߡ޿ࠆߩߢ޽ࠆ‫⾨࡞ࡌ࡯ࡁߒ߆ߒޕ‬ߪߣߦ߆ߊ‫ޔ‬27 ᐕ㑆౏⑳ߦࠊߚࠆ੤ᵹ߇⛯߈‫⥄ޔ‬ಽߩੱ↢ߦᄢ߈ߥᓇ㗀ࠍฃߌߚ⎇ⓥ⠪ߦߣߞߡ৻⇟ᄢಾߥߩߪ‫࡯ߛ↱⥄ޔ‬㧍ߘߒߡ⽿ോੱ↢ߢᦨ߽㊀ⷐߥߩߪ⥄↱ߢ‫߆ࠆࠇࠄ޿ߢ↱⥄ߦ߆޿ޔ‬߇ోߡߩ್ᢿߩၮḰߢ↢߈ߡ߈ߚ‫ߩߘޕ‬ᗧ๧ߢ‫ޔ‬ၮ␆කቇ⎇ⓥߪ࿶ୟ⊛ߦ⥄↱ߢ޽ߞߚ‫⥄ߦ․ޕ‬ಽߩ႐วߪ᫪Ꮉ‫ޔ‬Good వ↢ߣᏧߦ߽߼ߋ߹ࠇ‫⎇ޔ‬ⓥᚲߢ߽⇐ቇవߢ߽߿ࠅߚ޿ࠃ߁ߦ߿ࠇߚ‫ޕ‬਎⇇ฦ࿾ߦ಴ะ߈‫ޔ‬ㅢᏱߣߡ߽߅⋡ߦ߆߆ࠆߎߣߥߤ߆ߥࠊߧᐞੱ߆ߩࡁ࡯ࡌ࡞⾨ฃ⾨⠪‫ߒߘޔ‬ߡ఺∉ቇߩᏂੱ Good వ↢ߣ߽ኻ╬ߦળ⹤ߔࠆߎߣ߇น⢻ߛߞߚߩ߽‫⊒ߥ↱⥄ޔ‬ᗐߢ↢߈ߡ޿ߌࠆၮ␆කቇ⎇ⓥ⠪ߢ

-3-޽ߞߚ߆ࠄߎߘߢ޽ࠈ߁‫ߌߛ↱⥄ߩࠅ߇ࠃੱ৻ޔߒ߆ߒޕ‬ߢߪઁ߆ࠄ⹺߼ࠄࠇ‫ޔ‬ዅᢘߐࠇࠆߎߣߪߥ޿‫⥄ޕ‬ಽ߇૗߆ࠍ߿ࠅㆀߍࠆ⏕࿕ߚࠆ⥄ାߣ‫ࠆ߼⹺ࠍࠇߘ߇ઁޔ‬㑐ଥ߇ߥߌࠇ߫૗ߩᗧ๧߽ᜬߚߥ޿‫ޔߦ․ޕ‬ᄢㇱಽ౏㊄ߢ઀੐ࠍߒߡ޿ࠆ࿖┙ᄢቇᴺੱߩ৻ຬߢ޽ࠆએ਄‫ߦࠇߘޔ‬ᔕ߃ࠆ‫ޟ‬૗߆‫ࠍޠ‬࿖᳃ߦㆶరߒߥߌࠇ߫ߥࠄߥ޿‫ޕ‬⥄↱ߦ⎇ⓥߔࠆߚ߼ߦߪ‫৻ޔ‬ቯߩ⎇ⓥ⾌߇ᔅⷐߢ޽ࠆ‫ޕ‬ᄢㇱಽ߇୘ੱ⎇ⓥߦ㈩ಽߐࠇࠆ‫ޟ‬ၮ⋚⎇ⓥ‫ߦޠ‬㊀ὐ⊛ߦ↳⺧ߒ‫ࠍ⾌⎇⑼ߢ₸⏕ߩࠅߥ߆ޔ‬₪ᓧߢ߈ߚߩߪᐘ޿ߢ޽ߞߚ‫ޕ‬ਛߢ߽ 2002~2006 ᐕߦ₪ᓧߒߚ‫ޟ‬ၮ⋚ S‫ޔߪޠ‬ේೣ 5ᐕ㑆⛮⛯ߣᲧセ⊛㐳ᦼߩ㈩ಽߢ‫⎇ߦ↱⥄ޔ‬ⓥࠍㅴ߼ࠆߎߣ
߇ߢ߈ߚ‫ޕ‬ၮ⋚ S ߣߘߩᓟᒰߚߞߚ‫ޟ‬ၮ⋚ B‫ޔ‬2008~2010‫ޠ‬ߪ߆ߥࠅߩ㑆ធ⚻⾌߇ߟ߈‫ޔ‬ᄢቇߣ⎇ⓥᚲߦඨಽߕߟಽ㈩ߐࠇߡ޿ࠆߪߕߛ߇‫ޔ‬ᗵ⻢ߐࠇߚ⸥ᙘ߇ߥ޿‫⎇ޕ‬ⓥ⠪ߦ߿ࠆ᳇ࠍ⿠ߎߐߖࠆᗧ๧ߢ‫ߣߞࠂߜޔ‬⠨߃ߡ᰼ߒ޿‫ޕ‬෻㕙ࠣ࡞࡯ࡊߢ⋡⊛⎇ⓥࠍㅴ߼ࠆ⃰⎇ⓥߥߤߪ‫ߴࠆߥޔ‬ߊᏎ߈ߎ߹ࠇߥ޿ࠃ߁ߦߒߚ‫ⴕߡࠇ⟲ޕ‬േߔࠆߩ߇ህ޿ߥߎߣ߽޽ࠆ߇‫⃰ޔ‬ળ⼏ߥߤߦᤨ㑆ࠍขࠄࠇ‫⃰ߚ߹ޔ‬㐳߆ࠄࡊ࡟࠶ࠪࡖ࡯߇߆߆ࠆ‫↱⥄ߜࠊߥߔޔ‬ᐲ߇ૐ޿߆ࠄߢ޽ࠆ‫ޕ‬൩⺰‫ޔ‬᳇ߩวߞߚખ㑆ߩ⃰⎇ⓥߪߘࠇߥࠅߦෳടߒ‫ޔ‬㓐ಽഥ߆ߞߚ⚻㛎߽޽ࠆ‫ޕ‬ᦨㄭߪᄢቇ‫ޔ‬ㇱዪ‫⎇ߡߒߘޔ‬ⓥ⠪୘ੱߩ⹏ଔ߇⟵ോൻߐࠇߚ‫ߦ․ޕ‬ᴺੱൻᓟߪ‫⎇ޔ‬ⓥ⠪ߩ⢻ജ⹏ଔߦභ߼ࠆ㓸㊄ജߩ࠙ࠛࠗ࠻߇ᄢ߈ߊߥߞߚ‫⥄ޕ‬ಽ⥄り߽⒳‫⎇ߩޘ‬ⓥ⾌╬ߩክᩏຬࠍോ߼ߡ߈ߚ߇‫⺧↳ޔ‬⠪ߩᔅᱫߐ߇⋡ߦᶋ߆߮‫ߘޔ‬ࠇߢ߽◎ߦ߆ߌߥߌࠇ߫ߥࠄߥ޿ߩߪㄆ޿઀੐ߢ޽ߞߚ‫ޕ‬ᄢቇੱߦᐢ߹ࠅߟߟ޽ࠆ⚻ᷣఝవߩ㘑ầߪህߥߎߣߢ޽ࠆ‫ࠄ߆ࠇߎޕ‬ఝ⑲ߥੱ᧚߇㓸߹ࠆߩ߆‫ޔ‬ෂᗋߔࠆ‫ޕ‬⠡ߞߡ⥄ಽࠍ਄⸥ߩ⹏ଔ㗄⋡ߦᴪߞߚᒻߢ✚᜝ߔࠆߣ‫ޔ‬⥄ಽߥࠅߩ↢߈ᣇߢ⥄りߦ⑼ߒߚ઀੐ߪ߆ߥࠅ߿ࠅㆀߍ
ߚߣ⥄⽶ߒߡ޿ࠆ‫⥄ޕ‬ಽߢ⹏ଔ࡮್ᢿߢ߈ࠆߎߣߢߪߥ޿߇‫ࠆ޽ޔ‬⒟ᐲߩ⎇ⓥᬺ❣߽ᱷߖߚߒ‫⑼ޔ‬ቇ⎇ⓥ⾌╬߽ੱਗߺߦ₪ᓧߒ‫ޔ‬ቇળ߽ᐞߟ߆ਥ௅ߐߖߡ޿ߚߛ޿ߚ‫ޔߚ߹ޕ‬2007 ᐕߦߪ⑺ጊ⽷࿅⾨ࠍ޿ߚߛ޿ߚ‫ޕ‬㊒ࠅએᄖߢߪ࠻ࡠࡈࠖ࡯ߦ✼ߩή޿⥄ಽߦߣߞߡߪ‫ޔ‬ሜߒ޿‫ߡߒߘޔ‬ฬ⹷ߥᕁ޿಴ߢ޽ࠆ‫ޕ‬ᄢቇએᄖߢ߽ᄙߊߩክ⼏ળᆔຬߥߤ‫ߚ߹ޔ‬ᄙᢙߩ࿖ߩࠣ࡜ࡦ࠻ክᩏຬ߽ോ߼ߚ‫ޕ‬ᄢቇ⎇ⓥ⠪ߩ⟵ോߣ⠨߃‫⋧ޔ‬ᒰᢙߩ࿖㓙ࠫࡖ࡯࠽࡞ߩ࡟ࡈ࡝࡯߽ᭂജോ߼ߚ‫ޕ‬ߎࠎߥ⸒޿⸶ߓߺߚᦠ߈ᣇߦߥࠆߩߪ‫ߦߛᧂޔ‬ਇ⦟ቇ↢߆ࠄߩ⣕ළࠍᗧ⼂ߒߡ޿ࠆ᡿ߢ߅⸵ߒ޿ߚߛ߈ߚ޿‫ޕ‬ታ㓙ߪ‫ޔ‬ቇ↢ᤨઍ߆ࠄ฽߼ࠆߣ 45 ᐕ‫ޔ‬ᢎ᝼ߣߒߡ 23 ᐕ߽ߩ㑆ർᄢߦ↢߈‫ߩߘޔ‬㑆ᄙߊߩੱ‫ߦޘ‬ᡰ߃ࠄࠇ‫ߡߒߘޔ‬ఝ⑲ߥ⎇ⓥખ㑆ࠍᓧ‫ޔ‬⢒ᚑߒ‫ޔ‬ᐘㆇߦ߽⃻࿷ᚒ߇࿖ߩ࡜ࠗࡈࠨࠗࠛࡦࠬߩࡈࡠࡦ࠻࡜ࡦ࠽࡯‫ߡߒߘޔ‬Ᏹߦ໧㗴ᗧ⼂ࠍᜬߜ⛯ߌࠆ⥃ᐥකߥߤ‫᦭ޔ‬ὑߩੱ᧚ࠍ਎ߦㆶరߢ߈ߚߎߣ߇‫⥄ޔ‬ಽߩൟ┨ߣ⠨߃ߡ޿ࠆ‫ޕ‬㒝ዻᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯㐿⸳ߩߏ᜿ᜦ࠮ࡦ࠲г㐳 ⇗ጊ᣽ೣ㧞㧜㧜㧤ᐕ㧣᦬㧝ᣣ‫ޔ‬ർᶏ㆏ᄢቇㆮવሶ∛೙ᓮ⎇ⓥᚲߦ㒝ዻᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯߇㐿⸳ߐࠇ߹ߒߚ‫ޔߪ࡯࠲ࡦ࠮ᧄޕ‬㧞㧜㧜㧝ᐕᐲㆮવሶ∛೙ᓮ⎇ⓥᚲߩ㐿ᚲߣߣ߽ߦ⸳⟎ߐࠇߚ㒝ዻࡌࠢ࠲࡯㐿⊒࠮ࡦ࠲࡯ࠍ⊒ዷ⊛ߦᡷ⚵ߒ‫ޔ‬ᗵᨴߣ≸ࠍߟߥߋಽሶᯏ᭴ߩ⸃᣿ߥࠄ߮ߦߘߩᚑᨐࠍၮߦߒߚ㕟ᣂ⊛ߥᗵᨴ≸ᴦ≮ᴺ㐿⊒ࠍ⋡⊛ߣߒߡ⸳┙ߐࠇߚ߽ߩߢߔ‫ޕ‬ೋઍߩ࠮ࡦ࠲࡯㐳ߣߒߡ⇗ጊ᣽ೣ㧔ಽሶ⣲≌ಽ㊁ᢎ᝼ߣߩ૬છ㧕߇ዞછ޿ߚߒ߹ߒߚ‫ޕ‬㐿⸳ᤨߩኾછࠬ࠲࠶ࡈߪ‫ޔ‬ศጊ⵨ⷙḰᢎ᝼‫↰␹ޔ‬ノഥᢎ‫ߦ߮ࠄߥޔ‬ᩊ↰ᐘሶᛛⴚ⵬ഥຬߩ㧟ฬߢߔ㧔␹↰ഥᢎߪ㧞㧜㧜㧤ᐕ㧝㧜᦬㧝ᣣઃߌߢᗲ⍮⋵┙߇ࠎ࠮ࡦ࠲࡯⎇ⓥᚲߦォ಴ߐࠇߚߚ߼‫੹ޔ‬ᓟᓟછߩណ↪
߇੍ቯߐࠇߡ޿߹ߔ㧕‫ޕ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ߪ㧞㧜㧜㧤ᐕߦᣂ▽ߐࠇߚ⎇ⓥᚲᣂ᫟ߩ㧡㓏ߦ⸳⟎ߐࠇ‫ޔ‬2㧞ታ㛎ቶࠍ฽߻⎇ⓥㆀⴕ
ߦᔅⷐߥᦨᣂߩ⸳஻߇஻߃ࠄࠇߡ޿ࠆߣߣ߽ߦ㓞ធߔࠆ㒝ዻേ‛ታ㛎ᣉ⸳ߐࠄߦߪ⎇ⓥᚲߩઁߩಽ㊁ߣ߽᦭ᯏ⊛ߦㅪേߢ߈ࠆ⎇ⓥⅣႺ߇૞ࠅ಴ߐࠇߡ޿߹ߔ‫ޕ‬ᓸ↢‛ߩᜬ⛯ᗵᨴࠍၮ⋚ߣߔࠆ≸㧔ᗵᨴ≸㧕ߪࡅ࠻ో≸ߩ⚂㧟㧜㧑ࠍභ߼ࠆߣ⠨߃ࠄࠇߡ޿߹ߔ‫ޕ‬ઍ⴫⊛ߥ߽ߩߣߒߡ⢗≸ߣࡇࡠ࡝⩶‫ޔ‬⢄⚦⢩≸ߣ $ ဳ⢄Ἳ࠙ࠗ࡞ࠬ㧛% ဳ⢄Ἳ࠙ࠗ࡞ࠬ‫ޔ‬ሶች㗪≸ߣࡄࡇࡠ࡯ࡑ࠙ࠗ࡞ࠬ‫ޔ‬ᚑੱ 6 ⚦⢩⊕ⴊ∛ߣ *6.8ࡃ࡯ࠠ࠶࠻࡝ࡦࡄ⣲ߣ '$ ࠙ࠗ࡞ࠬ‫ޔ‬⢄ๆ⯻ߣ⢙▤⚦⢩≸ߥߤ߇਄ߍ
ࠄࠇ߹ߔ‫ࠄࠇߎޕ‬ᗵᨴ≸ߪ‫ޔ‬ේ࿃ߣߥࠆᓸ↢‛ߩ㚟ㅙߦࠃࠅቢ⅜ߥ੍㒐߇น⢻ߢ޽ࠆߣ޿߁ὐߢ␠ળ⊛ߦ߽߈ࠊ߼ߡ㊀ⷐߥᗧ⟵ࠍ᦭ߒߡ޿߹ߔ‫ޔߚ߹ޕ‬ᗵᨴ≸ߩ⊒∝ᯏ᭴ߪࠃࠅ৻⥸⊛ߥ⊒≸ᯏ᭴⸃᣿ߩߚ߼ߩᄙߊߩᖱႎࠍឭଏߒߡߊࠇࠆߎߣ߇ᄢ޿ߦᦼᓙߐࠇ߹ߔ‫ޕ‬ㆮવሶ∛೙ᓮ⎇ⓥᚲߪ≸ߣ఺∉ߦ㑐ߔࠆၮ␆⎇ⓥࠍㅢߒߡ㜞޿⹏ଔࠍฃߌߡ߹޿ࠅ߹ߒߚ‫߽ߢ߆ߥޕ‬ᗵᨴࠍၮ⋚ߣߔࠆ⊒≸⎇ⓥ‫ޔ‬ߣߊߦࡋ࡝ࠦࡃࠢ࠲࡯࡮ࡇࡠ࡝ߦࠃࠆ⢗⊒≸⎇ⓥߥࠄ߮ߦ

'RUVGKP$CTT ࠙ࠗ࡞ࠬߦࠃࠆ⚦⢩≸ൻᯏ᭴ߩ⎇ⓥߪ࿖㓙⊛ߦ߽㜞ߊ⹏ଔߐࠇߡ޿߹ߔ‫ߢߎߘޕ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ߪ‫ޔ‬ㆮવሶ∛೙ᓮ⎇ⓥᚲߩฦಽ㊁ߢ⁛┙ߒߡㅴ߼ࠄࠇߡ޿ࠆᗵᨴ≸⎇ⓥࠍࠃࠅ㜞ᰴߩ࡟ࡌ࡞ߢ⛔วߒߚ࠹࡯ࡑࠍㅊ᳞ߒ‫ޔ‬㕟ᣂ⊛ߥᴦ≮ᴺ㐿⊒߳ะߌߡߩᣂߚߥ⎇ⓥၮ⋚ࠍഃ಴ߔࠆߎߣࠍ⋡⊛ߣߒߡ⸳┙ߐࠇ߹ߒߚ‫ౕޕ‬૕⊛ߦߪ‫࠻ࠬࡠࠢߩ⩶⚦ߣࠬ࡞ࠗ࠙ࠆߌ߅ߦ≸⊒ޟ‬࡯ࠢᯏ᭴ߩ⎇ⓥ‫ޟߦ߮ࠄߥޠ‬ᗵᨴ⊒≸ߦ౒ㅢߔࠆಽሶᯏ᭴ߩ⸃᣿‫ޠ‬ࠍㅢߒߡ⚦⩶ᗵᨴ≸߆ࠄᓧࠄࠇࠆ⊒≸ߩࡠࠫ࠶ࠢࠍࠃࠅ᥉ㆉ⊛ߥ≸ߩ⊒∝ᯏ᭴ℂ⸃ߦߟߥߍ‫⺰ޔ‬ℂ⊛⢛᥊ߦⵣᛂߜߐࠇߚ≸೙࿶߳ߩ㆏ࠍಾࠅ㐿޿ߡ޿߈ߚ޿ߣ⠨߃ߡ߅ࠅ߹ߔ‫ޕ‬ᗵᨴ≸ߩ㊀ⷐߥ․ᓽߪ‫∛ޔ‬ේᓸ↢‛ߩ㚟ㅙ߇⋥ߦ≸ߩ੍㒐ߦߟߥ߇ࠆߣ޿߁ߎߣߢߔ‫ߢߎߘޕ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ߢߪ‫ޔ‬਄⸥ߩၮ␆⎇ⓥࠍផㅴߔࠆ߫߆ࠅߢߥߊ‫ޔ‬ᗵᨴ≸೙࿶ߦะߌߡߩౕ૕⊛ߥࠕ࡚ࠢࠪࡦࡊࡠࠣ࡜ࡓ߽តߞߡ޿ߊߎߣ߽ᄢ߈ߥ⋡⊛ߣߒߡ߹ߔ‫᦭ߡ߼ࠊ߈ߪߦ⩶࡝ࡠࡇޔ߫߃ߣߚޕ‬ലߥ᛫↢‛⾰߇ሽ࿷ߒ߹ߔ߇‫ోޔ‬਎⇇ߢ㧟㧜ంੱߣ޿߁ࡇࡠ࡝⩶ᗵᨴ⠪ߩ⛘ኻᢙߩᄙߐ߇੍㒐⊛㒰⩶ߦߣߞߡߩᄢ߈ߥ໧㗴ߣߥࠅ߹ߔ‫ߢߎߘޕ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ߢߪ‫≸⊒ޔ‬ଦㅴߦ㑐ਈߔࠆ⩶஥ߥࠄ߮ߦኋਥ㧔ࡅ࠻㧕஥ߩㆮવ⊛࿃ሶหቯࠍㅢߒߡ‫ޔ‬㜞ෂ㒾⟲ߩ⛉ࠅㄟߺࠍน⢻ߦߔࠆࠬࠢ࡝࡯࠾ࡦࠣ♽ࠍ᮸┙ߒ‫⥃ޔ‬ᐥߩ႐ߦㆡ↪ߒߚ޿ߣ⠨߃ߡ޿߹ߔ‫ޕ‬৻ᣇ‫ߩࠬ࡞ࠗ࠙≸⊒ޔ‬㚟ㅙߪ⚦⩶ߦᲧߴኈᤃߢߪ޽ࠅ߹ߖࠎ߇‫ޔ‬ᧄ⎇ⓥᚲߢㅴ߼ࠄࠇߡ޿ࠆ &0# ࠮ࡦࠨ࡯‫ޔ‬40#࠮ࡦࠨ࡯⎇ⓥ╬ࠍㅢߒߡ‫ࠬ࡞ࠗ࠙ޔ‬ᗵᨴߦኻ᛫ߔࠆ⥄ὼ఺∉♽ߩലᨐ⊛ߥᵴᕈൻࠍน⢻ߦߔࠆ⎇ⓥࠍዷ㐿ߒߚ޿ߣ⠨߃ߡ޿߹ߔ‫ޕ‬ᗵᨴ≸ߪੱ㘃ߩ⧷⍮ߣദജߦࠃࠅᠡṌ߇น⢻ߥ≸ߢߔ‫ޕ‬ᗵᨴ≸⎇ⓥ࠮ࡦ࠲࡯ߪߎߩ⋡ᮡ㆐ᚑߦะߌߡߩࠦࠕ⎇ⓥ࠮ࡦ࠲࡯ߣߒߡ
☽‫⎇ߣޘ‬ⓥࠍ㊀ߨߡ޿߈ߚ޿ߣ⠨߃ߡ߅ࠅ߹ߔ‫⊝ޕ‬᭽߆ࠄߩᥦ߆
޿ߏᡰេࠍ⾦ࠅ߹ߔࠃ߁߅㗿޿↳ߒ਄ߍ߹ߔ‫ޕ‬㒝ዻേ‛ታ㛎ᣉ⸳ᣉ⸳㐳 㧔૬㧕ᢎ ᝼  ᔒ↰ᄈ೑㧔૬㧕ಎᢎ᝼  ᫪᧻ᱜ⟤㧔૬㧕ഥ ᢎ  ንጟᐘሶ㩷 ᧄᣉ⸳ߪ‫ޔ‬ㆮવሶ∛೙ᓮߩ⎇ⓥߦ↪޿ࠄࠇࠆേ‛ታ㛎߇㜞޿♖ᐲߣౣ⃻ᕈࠍ߽ߞߡታᣉߐࠇࠆߎߣࠍ⋡⊛ߣߒߡ‫ޔ‬2000 ᐕ 4 ᦬ߦ⸳⟎ߐࠇߚ‫ߩߘޕ‬೨りߪ‫ޔ‬1976 ᐕߦ⸳⟎ߐࠇߚ఺∉⑼ቇ⎇ⓥᚲ㒝ዻ఺∉േ‛ታ㛎ᣉ⸳ߢ޽ࠆ‫ޕ‬2008 ᐕ㧠᦬ߦో㕙ᡷୃᎿ੐ߐࠇߚᣉ⸳߇㐿⸳ߒ㧘㘺⢒▤ℂ⸳஻߇᜛లߐࠇߚ‫ޕ‬ᣉ⸳ౝߦߪ৻⥸⊛ߥേ‛㘺⢒㧝㧟ቶߩઁ㧘࠻࡜ࡦࠬࠫࠚ࠾࠶ࠢࡑ࠙ࠬ૞⵾↪ታ㛎ቶ‫ޔ‬㨄✢ᾖ኿ቶ‫ޔ‬㧼㧟ᗵᨴታ㛎ቶ㧘P㧞ᗵᨴታ㛎ቶ‫ޔ‬ᬌ∉ቶߥߤ߇ᢛ஻ߐࠇ‫ోޔ‬㙚ߦⓨ⺞⸳஻߇ቢ஻ߐࠇߡ޿ࠆ‫ޕ‬ㅏ੢㒐ᱛភ⟎↪ߩࠗࡦ࠲࡯ࡠ࠶ࠢઃ߈㧞㊀ᚺߣ‫ޔ‬ᜰ㕒⣂⹺⸽ߢߩᚺߩ㐿㐽ߦࠃߞߡ࠮ࠠࡘ࡝࠹ࠖ࡯߇⏕଻ߐࠇߡ޿ࠆ‫ޕ‬⢦߳ߩㆮવሶዉ౉↪ࡑࠢࡠࠗࡦࠫࠚ࡚ࠢࠪࡦⵝ⟎㧘ࠛ࠶ࠢࠬ✢ᾖ኿ⵝ⟎‫ޔ‬⢦ಓ⚿↪ᶧ૕⓸⚛ኈེ╬߇⸳⟎ߐࠇߡ޿ࠆ‫ޕ‬਄⸥ᢎቭએᄖߦ‫ޔ‬ታ㛎ᛛⴚᡰេ㧔⢦ಓ⚿଻ሽ‫ޔࡊ࠶࠽ࡦ࡯࡝ࠢޔ‬ᬌ∉㧘․ᱶណⴊ╬㧕ࠬ࠲࠶ࡈ㧝ฬ‫ޔ‬㘺⢒↪ౕ⺞⵾ࠬ࠲࠶ࡈ㧞ฬߢᣉ⸳ࠍേ߆ߒߡ޿ࠆ‫ᧄޕ‬ᣉ⸳ߢታᣉߐࠇࠆోߡߩേ‛ታ㛎ߪ‫ޔ‬ㆮવሶ∛೙ᓮ⎇ⓥᚲേ‛ታ㛎ᆔຬળߦࠃࠆᜰዉߩਅ‫⑼ޔ‬ቇ⊛߅ࠃ߮േ‛⑔␩ߩⷰὐ߆ࠄ߽ㆡᱜߦⴕࠊࠇߡ޿ࠆ‫⃻ޕ‬࿷‫ࠬ࠙ࡑޔ‬㧔㧝㧡㧜㧜ࠤ࡯ࠫ㧕ߣ࡜࠶࠻㧔㧤㧜ࠤ࡯ࠫ㧕߇㘺⢒น⢻ߢ޽ࠆ‫ޕ‬ㄭ੤♽േ‛߿ㆮવሶᠲ૞േ‛㧔࠻࡜ࡦࠬࠫࠚ࠾࠶ࠢേ‛㧘ࡁ࠶ࠢࠕ࠙࠻േ‛㧕ࠍ↪޿ߡ‫∉఺ޔ‬ᯏ᭴ߩ⸃ᨆ‫≮∉఺ߩࡦࠟޔ‬ᴺ‫࠙ࡑߩ࡝ࡠࡇ࡯࠲ࠢࡃࠦ࡝ࡋޔ‬ࠬࡕ࠺࡞‫ߩࠬ࡞ࠗ࠙ࡠ࠻࡟࠻ࡅޔ‬ᗵᨴࡕ࠺࡞ߩࡊࡠࠫࠚࠢ࠻߇ㅴⴕਛߢ޽ࠆ‫ޕ‬-4-߹ߚ‫ޔ‬ᗵᨴታ㛎ቶߢߪ‫ޟ‬቟ోᐲ㧞߅ࠃ߮㧟‫ߩޠ‬ᗵᨴታ㛎߇ⴕࠊࠇߡ޿ࠆ‫࡯ࡇ࠻ࠕޕ‬ᕈ⊹⤏Ἳࡕ࠺࡞‫ޔ‬ㆮવᕈ੃≸ࡕ࠺࡞‫ޔ‬઒ᕈ⁅›∛ᛶ᛫ᕈേ‛߇ᧄᣉ⸳ߢ⁛⥄ߦ૞ᚑߐࠇߚታ❣ࠍᜬߟ‫ޕ‬ ቇᄖ⠪ߩ౒ห೑↪ߩߚ߼ߦ‫ޔ‬㘺⢒ቶ㧝ቶ㧔ࡑ࠙ࠬ㧝㧞㧜ࠤ࡯ࠫ߹ߚߪ࡜࠶࠻㧤㧜ࠤ࡯ࠫ෼ኈน⢻㧕߇Ḱ஻ߐࠇߡ޿ࠆ‫ޕ‬෶‫ޔ‬P3 ࡟ࡌ࡞ㄥߩᗵᨴታ㛎߽น⢻ߢ޽ࠆ‫ޕ‬㩷࿑䋱䋮േ‛ታ㛎ᣉ⸳䈱⸳஻㩷 㩿Fig. 1. Experimental animal facilities and equipments.)㩷㩷㩷㪘㪑ⓨ⺞⸳஻೙ᓮⵝ⟎㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㪙㪑ਔᚺᑼ䉥䊷䊃䉪䊧䊷䊑㩷
A: Air conditioning systems.
B: Double-door barrier autoclaves.

㩷㩷㩷㪚㪑㪪㪧㪝 േ‛㘺⢒ቶ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㪛㪑䌐䋳䉪䊤䉴ᗵᨴታ㛎ቶ㩷
C: SPF animal room.
D: Biosafety level P3 room for animals experimentally
infected with highly virulent microbes.

(Fig. 2.

࿑䋲䋮ㆮવሶ⚵឵䈋䊙䉡䉴䉕૞⵾䈜䉎䈢䉄䈱⢦ᠲ૞Germ cell manipulation to generate genetically engineered mice.)

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Division of Signaling in Cancer and Immunology㜟ጟᤩᢎAkinori Takaoka ᐘㆇߦ߽ᤓᐕ ᐔᚑ  ᐕ ߩ  ᦬  ᣣߦᒰㆮવሶ∛೙ᓮ⎇ⓥᚲߦ⎇ⓥቶࠍ᭴߃ࠆᯏળࠍ㗂߈߹ߒߚ‫ߩߎޕ‬༑߮ߪએਅߩ㧟ߟߩߎߣߦⵣઃߌࠄࠇߡ߅ࠅ߹ߔ‫ߩࡓࠕ࠾࡟ࡒޔߕ߹ޕ‬ᐕߦ‫⃻ޔ‬࿷ߩ‫ޟ‬ㆮવሶ∛೙ᓮ⎇ⓥᚲ‫߁޿ߣޠ‬ฬ೨ߢ᜛ᄢൻߒߚᒰ⎇ⓥᚲߪ‫ޔ‬㆚ࠆߎߣ‫ޔ‬ታߦ㧣㧜ᐕㄭߊ߽ߩ㐳޿ᱧผ߇޽ࠅ߹ߒߡ‫⎇ߥ߁ࠃߩߎޔ‬ⓥᚲߦ⌕છߐߖߡ޿ߚߛߌࠆߎߣߦߥࠅ߹ߒߚߎߣߪᄢᄌశᩕߢߏߑ޿߹ߔ‫⎇ᧄޔߚ߹ޕ‬ⓥᚲߪ‫⑼∉఺ߩߢ߹ࠇߎޔ‬ቇ⎇ⓥᚲߣකቇㇱ㒝ዻ≸⎇ⓥᚲߩੑᣉ⸳߇
⚵ࠎߢᣂߚߦ᜛ᄢൻߐࠇߚᨒ⚵ߺߢ⸳⟎ߐࠇߚ⎇ⓥᚲߢ޽ࠆߣ޿߁ᱧผ⊛ߥ⢛᥊߆ࠄ⠨߃‫ߦߐ߹ޔ‬ᗵᨴߣ߇ࠎߣ޿߁⑳ߩ⎇ⓥኻ⽎ߣ৻⥌ߒߡ޿ࠆߎߣߢߏߑ޿߹ߔ‫߁߽ߡߒߘޕ‬㧝ߟߪ‫ࠇ߹↢ࠄ߆ߡ੍ޔ‬⢒ߞߚർᶏ㆏ߩ࿾ࠍ᜚ὐߣߒߡ઀੐ࠍዷ㐿ߒߚ޿ߣᕁߞߡ޿ߚߎߣߢߏߑ޿߹ߔ‫ޕ‬ એ਄ߩ㧟ߟߦട߃‫ߦࠄߐޔ‬༑߫ߒ޿ߎߣߦᧄᐕ  ᦬ࠃࠅ⎇ⓥᚲో૕߇ർ⎇ⓥ᫟ߦ㓸⚿ߒ‫ޔ‬ᣂⵝࠝ࡯ࡊࡦ޿ߚߒ߹ߒߚ‫ޕ‬⑳ߩ⎇ⓥቶߪ‫⎇ߩߘޔ‬ⓥᚲߩᱜ㕙౉ࠅญࠍ౉ߞߡߔߋߩ  㓏ߦߏߑ޿߹ߔ‫⎇ᧄޕ‬ⓥᚲߦߪᄢ߈ߊ∛࿃‫∛ޔ‬ᘒ‫∔ޔ‬ᖚ೙ᓮߩ㧟ߟ⎇ⓥㇱ㐷ߦಽ߆ࠇߡฦಽ㊁߇ሽ࿷ߒߡ߅ࠅ߹ߔ߇‫ޔ‬ᒰ⎇ⓥቶߪ‫∛ޔ‬࿃⎇ⓥㇱ㐷ߦᚲዻߒ‫ޔ‬‫ޡ‬ಽሶ↢૕㒐ᓮಽ㊁ &KXKUKQP
QH5KIPCNKPIKP%CPEGTCPF+OOWPQNQI[‫߁޿ߣޢ‬ᣂߒ޿ฬ⒓ߢࠬ࠲࡯࠻ߐߖߡ޿ߚߛߊߎߣߦߥࠅ߹ߒߚ‫ޕ‬ᒰೋ‫ࠍ⑳ޔ‬฽߼‫ޔ‬㧢ฬߩࠬ࠲࠶ࡈ߇┙ߜ਄ߍߦߏദജ޿ߚߛ߈߹ߒߚ‫ߢ߹ࠇߎޕ‬ห⎇ⓥᚲߩ೎ߩಽ㊁ߦ߅ࠄࠇߚἏᧄ዁ੱಎᢎ᝼ߣㄭ⇰ᄢ߆ࠄ߈ߡ޿ߚߛ޿ߚᣧᎹᷡ㓶ഥᢎ‫ߚ߹ޔ‬ർᄢᱤቇ⎇ⓥ⑼߆ࠄߩቴຬ⎇ⓥຬߣߒߡෳടߒߡ޿ߚߛ޿ߚ⪾Ꮞືవ↢ߩઁ‫ޔ‬ห⎇ⓥᚲ࿷☋ᐕᢙ߇࠻࠶ࡊࠢ࡜ࠬߩࡌ࠹࡜ࡦᛛⴚ⡯ຬߢ޽ࠆศ↰ᩕሶߐࠎߣࡑ࡞࠴ߥᚽ⢻ࠍ߽ߟ੐ോ⵬૒ߩ૒⮮⵨㚅ߐࠎߘߒߡ⑳ߢߔ‫ޕ‬߹ߚᒰ⎇ⓥቶߪർᄢℂቇㇱൻቇኾ᡹ߩදജ⻠ᐳߣߒߡ߽ෳടߐߖߡ޿ߚߛߊߎߣߦߥࠅ‫߽ߣ߭ߗޔ‬ൻቇߣකቇߩ᨞ߌᯅ⊛ߥᓎഀߣߒߡᢎ⢒ߦ߽Ⓧᭂ
⊛ߦ⽸₂ߔࠆߎߣ߇ߢ߈ࠇ߫ᐘ޿ߣሽߓ߹ߔ‫ޕ‬ᐔᚑ㧞㧜ᐕ㧝᦬߆ࠄߪ‫ޔ‬ᣧㅦ‫ޔ‬ൻቇ⑼㧟ᐕߩᓟ⮮⠍ᐔำ‫ޔ‬ᮯᧁ⦹⟤ߐࠎ߇ෳടߒߡߊࠇࠆߎߣ߇᳿߹ࠅ‫⃻ޔ‬࿷ᒁ߈⛯߈තᬺ⎇ⓥࠍ⛮⛯ߒߡ޿ࠆߣߎࠈߢߔ‫ࠄߐޕ‬ߦਛ࿖߆ࠄߩ⎇ⓥຬߣߒߡ๟⦣⦣ߐࠎ߇ඨᐕ㑆ߢߪ޽ࠅ߹ߒߚ߇ෳടߒߡ޿ߚߛ߈߹ߒߚ‫ޕ‬ᐔᚑ㧞㧜ᐕ㧠᦬߆ࠄߪർᄢߩ∛ᘒౝ⑼ቇ⻠ᐳᶖൻེౝ⑼ቇ
ಽ㊁㧔ᵻ㚅ᱜඳᢎ᝼㧕ߣౝ⑼ቇ⻠ᐳⴊᶧౝ⑼ቇಽ㊁㧔੹᧛㓷ኡᢎ᝼㧕ߩᄢቇ㒮↢ߢ޽ࠆฦ‫ޘ‬ᄢ๺ᒄ᣿ߐࠎߣ⊕㠽⡡৻ߐࠎߩ㧞ฬߩઁ㧤᦬߆ࠄߪᣂߚߦ᦭⢻ߥᛛⴚ⵬૒ߣߒߡᢙ㚍↰⟤㚅ߐࠎ߽ෳ↹ߒߡ޿ߚߛߌࠆߎߣߦߥࠅ‫⃻ޔ‬࿷㧝㧝ฬߩࡔࡦࡃ࡯ߦߥࠅ߹ߒߚ‫ޕ‬⎇ⓥቶࡔࡦࡃ࡯
Ꮐ߆ࠄ૒⮮‫ޔ‬ᢙ㚍↰‫ޔ‬ᣧᎹ‫ޔ‬ᓟ⮮‫ޔ‬ศ↰‫ޔ‬ᄢ๺‫ޔ‬ᮯᧁ‫ޔ‬Ἇᧄ‫⊕ޔ‬㠽‫ޔ‬㜞ጟ
⑳ߪ‫ᧅޔ‬ᏻක⑼ᄢቇ╙৻ౝ⑼㧔᡿‫⼱ޔ‬ౝᤘవ↢‫⃻ޔ‬ቇ㐳‫੹ޔ‬੗ᶈਃవ↢㧕ߩᄢቇ㒮ࠍතᬺߒ‫ޔ‬⃻⡯ߦ⌕છߔࠆ߹ߢ߅ࠃߘ㧝㧝ᐕ㑆‫᧲ޔ‬੩ᄢቇකቇ⎇ⓥ⑼఺∉ቇ⻠ᐳ㧔⼱ญ⛽⚫ᢎ᝼㧕ߢ⎇ⓥࠍ
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tumor-escape mechanisms.‫ޠ‬ᣣᧄࡠ࡟ࠕ࡞ᩣᑼળ␠ߣᣣᧄ࡙ࡀࠬࠦ࿖ౝᆔຬળ߇౒หߢផㅴߔࠆ╙ 3 ࿁‫࡞ࠕ࡟ࡠޟ‬-࡙ࡀࠬࠦᅚᕈ⑼ቇ⠪ᣣᧄᅑബ⾨‫ޔࠍޠ‬ಽሶ⣲≌ಽ㊁ߩᄢ⷏ߥ߅ߺ⎇ⓥຬ߇ฃ
⾨ߒ߹ߒߚ‫ޕ‬‫ߩߎޟ‬ᐲߪりߦ૛ࠆ⾨ࠍฃ⾨ߐߖߡ㗂߈శᩕߦሽߓ߹ߔ‫ߩ⾨ᧄޕ‬ฃ⾨ߪᧄᒰߦᄙߊߩᣇߩߏᜰዉࠍ⾦ࠅᚑߒᓧߚ߽ߩߢ‫౒ޔ‬ห⎇ⓥ⠪ࠍߪߓ߼⊝᭽ߦᔃࠃࠅ߅␞↳ߒ਄ߍ߹ߔ‫੹ޕ‬ᓟ߽⎇ⓥߦ♖ㅴߒߡ޿߈ߚ޿ߣᕁ޿߹ߔ‫ޠޕ‬‫ޕߔ߹޿ߑߏ߁ߣ߇ࠅ޽ޟ‬ᄙߊߩవ↢ᣇࠍᏅߒ⟎޿ߡ⥄ಽߏߣ߈߇ฬ⹷޽ࠆ⾨ࠍฃ⾨ߒߚߎߣߦࡊ࡟࠶ࠪࡖ࡯߽ᗵ
ߓ߹ߔ߇‫߽ߡߣޔ‬శᩕߥߎߣߛߣᕁ޿߹ߔ‫ࠍࠇߎޕ‬ബߺߦ߹ߔ߹ߔ⎇ⓥߩ਎⇇ߦᴚ㗡ߒߡⴕߌࠇ߫ߣᕁ޿߹ߔ‫ޠޕ‬ㆮ೙⎇ News Letter ╙ 1 ภ⊒ⴕ㧦ർᶏ㆏ᄢቇ ㆮવሶ∛೙ᓮ⎇ⓥᚲ
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