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Walker FB 4th. Annals of internal medicine. 1984 Oct;144(10):2089-90.
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Chow WH, Chow TC, Tse TM, Tai YT, Lee WT. Postgrad Med J. 1990 Oct;66(780):855-7
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Warfarin dosage and vitamin K in Osmolite.
Lader E, Yang L, Clarke A. Annals of internal medicine. 1980 Aug;93(2):373-4.
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O'Reilly RA, Rytand DA. N Engl J Med. 1980 Jul 17;303(3):160-1.
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Inhibition of the hypoprothrombinemic effect of warfarin (Coumadin) by Ensure Plus, a dietary
supplement.
Michaelson R, Kempin SJ, Navia B, Gold JW. Clinical bulletin 1980;10(4):171-2.
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Warfarin resistance and vitamin K.
Lee M, Schwartz RN, Sharifi R. Annals of internal medicine. 1981 Jan;94(1):140-1.
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10fA.»¼LFYZ.§¿17fÀ[…e`†LFS10 mg/fTYZ9¯°<1>.?.1f¬97.5 mg[</[Á¥¥Â¡Ã1-]š]FCF®AB±²<I¥Ä/=…e`†LF’“t.wÅ.ÆÇ¥¡1$%BEnsure9gh<iJ/=>.?1È¬.CDEFK9GÉMeritene[Ê"ËÌ15 mg.…e`†LF—-]š]FCF®ABYZÍ4[IÄ/=…e`†LFcFš]de”›œI•ž[Ÿ </¡1CDEFKG¢£¤9gh<iJIJ¥¦§¥1¨Œ©ª«—˜™=
R~•€•‚.CDEFKG¬.LMš”Table 1Sp. 140T[˜"=…e`†LF1Ensure1CDEFK1-]š]FCF®A1…e`†LF’“tEnsure.gh¯°?1-]š]FCF®A”±²<IJ=
ÎZÏÐ%[jkÑÃR~•€•‚9gh</ÒÓ1“ÔÕÖ.¢×t”Ø¡•I¥Ä/Xl—˜™=ÙCDEFK.•€•‚[Ê"ËÌ™ºU[!"1-]š]FCF®ABYZÍ4[IÄ/=R~•€•‚[!ÄiCDEFKG¬BÚI™.—1‡ˆ“ÔÕÖÛÜ$%[ÝJiBÞ[ßà©ª«—˜™=

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PubMed!"KnlmaCase reportskfˆ‰TK@’“”•ƒ)„…†1!"2ƒ•–—˜™1š›œ–E@•žŸ ›ZKn•N^:Enteral feeds may antagonise warfarin.
Watson AJ, Pegg M, Green JR. Br Med J (Clin Res Ed). 1984 Feb 18;288(6416):557.
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Kuykendall JR, Houle MD, Rhodes RS. Ann Pharmacother. 2004 Apr;38(4):595-7
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PubMed!"Vitamin K intake and sensitivity to warfarin in patients consuming regular diets.
Lubetsky A, Dekel-Stern E, Chetrit A, Lubin F, Halkin H. Thrombosis and haemostasis 1999
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Khan T, Wynne H, Wood P, Torrance A, Hankey C, Avery P, Kesteven P, Kamali F. Br J Haematol. 2004
Feb;124(3):348-54.
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Treatment of natto, a fermented soybean preparation, to prevent excessive plasma
vitamin K concentrations in patients taking warfarin.
Homma K, Wakana N, Suzuki Y, Nukui M, Daimatsu T, Tanaka E, Tanaka K, Koga Y,
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Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1
content.
Booth SL, Charnley JM, Sadowski JA, Saltzman E, Bovill EG, Cushman M. Thrombosis and haemostasis
1997 Mar;77(3):504-9.

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pYZ4eqÈ6Át6¸¹tÉ‰§'PhÊOÔ7dPh#°0¯'MNe6Nutrition Coordination Center„ëËÉÊp
Minnesota Nutrient Data System softwaredFood Database, version 6A; Nutrient Database, version 21,
1993elƒTotZ[opqÁt6:ˆŒ§'O>ÌÔ76Metabolic Nutrition Laboratory„deo'ÍÎopqÏ^_`1§'Nutrition
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ø*+|ù69]lëìopM…UjkÉÊt¦XqPedersengYZ5e¶OversengYZ6e§'NOP@K1lÞúûU‹Œö÷
6#,üýþ6*+§wxyz{UôoõwSTl•W‚'NOP@K1‹Š6®¦*+„§ÿ!gÊ‡fÜpÀMl–"t¦!KLMNOPQR(

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45„¥Xquvwxy¢6/@%-1=64›‰¤l1…™ÀW*+—˜623óàáUÄ4òot¦XqÀÊ§ö÷*+|6ÞNOP
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ÊpÑÒ69]FkU•Üp8400 kJdn2000 kcale6^_`16C8„¥Xqäp'^_`16GH¤lI¶Wp!'NOP@K1‚70-140 µg/7U‡X!†‡9ª6JKiÄTable 3U•opq
NOP@K6Qôó;LM#NLüN0žOl[PpJQRS„§'Table 2„•op^_`1MTable 3UTUopJKªlƒ
Tot'37&6VJW69]lX‰opq3•6YÐ6^_`1U»¦t'Z[ÉÊpNOP@K1‹Šd\]±SDe§98±6 µg^ÜpqÀÊg63•69]§12_`UapÜt10$6YÐ6bcUdeopØ'f’gh1%lHPLC„ijWXM'\]NOP@K1‹Š§100±12 µg^Üpqk~g6JQRS„§'NOP@K6)llm‡ÆWXp!'noop*+lGŠUp
qopdrs*+6¸¹t‹Š6)lu§Ô…¦p!eq()9ª6<)'ÄovÊg‚À6NOP@l¨©U‹ŒÔw'M01,'“x•1üylƒTot¦pg'GŠ6NOP@K1l‹ŒfÄoÊ‡¦qÃÄˆzó„{|óU}TÉÊp~6y§'~6y6|„ÃÄNOP@K1‹Š‚Þ¦ÀM„Ä•gÊt¦X
Ôw^Üpqofo'{ª„}TÉÊp~6y6€•6OL‘§'Ø‚¶ƒ„¤6)l6p!9ªüN=„oÝoÝ½‰„…
‡¦6„'NOP@K1—˜6)l‚™ÀXÌšMotÿ…WP…„¥Xq†ü‡&:.ˆ@‰'H>O@¶()9ª6!†‡ïŠ‹:ˆŒ„ƒTopy6OL‘§'9]6ÁLó‡•Ž‹Šl)•É*•U9]|6NOP@K1‹Š6[3‚‘’„¥Xq9]fg½‰6yl“”*•UNOP@K1—˜l®±É*Xp!6ˆ•6•–Mot'27&7—¥X¦§˜—™UylšWM'NOP@K1646-94%‚›œÉÊXÀM‚jkÉÊt¦Xq

ÐÑ%89:;_@!"#$%&'()K1-ÒÓÔ©ªÕ*%0123<ºÖ67r%WXsMJ@&'()K14]67uv%!cwxRQ'×QØª‰%yzxa4–f@gbh%01234_ÙÚJXsMYÎÛÅÆnh%ÜÝ–f@&'()K«¬_—Þ_ßà%!"kl4–fáLab@âãd&'()K1ä×,_—LI%&'(!"#$%&'()!*+))Kkl4–få¡æç4KLè67Ÿ*JºÖabMYgbé€@ßà%!"nh%&'()K1kl_¡êF4&'()K%ëì«¬%íî<ÌÍ67M¸4¹=WX7Y+,-./)3IJ1 mg*¨3I%ï3ð¤<žñ67*@!"nh%&'()K1kl%òO'/)ó_¹=4G7nr?bGqY&'()K%RDA_©ª')ôõ%ö•4÷øq~q7J@¦=G&'()KI_ù<H¸úû%&'()Küý{')ôõ4œ
q~þÿWX7*q’Ÿ*J!µab~q7Y"vŠ4pM7+,-./)#$d%%{BC4œq~@ù(&Ä,'ŒJ‰(4)*?MŸ*r:;ab~q7Ygbé€@š»%RDAæ+%&'()K1<!"nh,{F4kl67Ÿ*_@+,-./)%-Ô234–s~.è?@/0Gù4]?"vF12J34ab7nr?bGqY
VZ[\%±²@&'()K*+,-./)%0123%:;_@q³r!cd%&'()KHI4–s~´µW°7*q’p¥
W_Gqnr?bGqY?n?@!"nh—LI%&'()Kkl_¡¶%&'()K«¬<·³M¸4¹=WX7Ÿ*Jºab
MYg?~@š»%RDA40¼67–’GKL?M&'()K1klJŽ•G!"NOPQ<:;?MY½¾@!"#$%&'()
K1*+,-./)*%0123<µhn467M¸%¿¤°˜™ÀÁJ¦=WXf@ŸŸW:;?M!"%ÂTÃÄT)_g%–’GÅÆ4œq~•3ab7nr?bGqY!"#$%&'()K1*+,-./)*%0123<:;?M89:;JTable 1Çp. 505È4XfY!,-)+,-./)A3d%BC4]?@š»%RDA% 1 µg&'()K1/kgÉ¹/¡40¼67Ê)Ë,NOPQJTable 2Çp.
506È4XfY+,-./)A3d%BC4]?@70-140 µg/¡%&'()K1<ÌÍ67–’GÊ)Ë,NOPQ%ÎÏ!cJTable 3Çp.
507È4XfY!./0/1)+,-./)@&'()K1@VZ[\@!"%NOPQ!23456789)

89:;%VZ[\–f@!"#$%&'()K1*%§34–f@¨©ª«¬X7q_-®G©ª«¬J¯°mŸabMY

!Abstractor$%&'()!"#$%&'()K1*+,-./)*%0123456789:;<=>?@+,-./)A3BC4DEFG&'()KHI
JKL?M!"NOPQ<RST)?MUVWX7YVZ[\%]^_89:;%`W@0123%:;abM!cd%&'()K1HI_eJXf@gbh%0123%ijJ&'()K1kl4mj67%nop?q89rXsM%W@tCh_@uv%!cwxRQ'%yzx{4ijJX7*|}?~qMY?n?@gb4•€@•‚%!ƒ„…%BC†‡ˆ@&'()KH‰!c%klvŠˆ‹Œ45•67Ž•{rX7•‘’Y“M@+,-./)A3BC4”•ab7–’G&'()K1HI<—L4?MNOPQ_˜™š›4œq~•3?ˆ6q*ž€hb7%W@Ÿbh< ž4?~¡¢!4–7¡¢£¤¥%N
OPQ%2wr¦=nr?bGqY!:3;<)

VZ1): Booth SL, Sadowski JA, Weihrauch JL, Ferland G. Vitamin K1 (Phylloquinone) Content of Foods: A
Provisional Table. J Food Compos Anal 1993: 6: 109-20.
VZ2)5Ferland G, MacDonald DL, Sadowski JA. Development of a diet low in vitamin K1 (phylloquinone).
J Am Diet Assoc 1992: 92: 593-7.
VZ3): Booth SL, Sadowski JA, Pennington JAT. Phylloquinone (Vitamin K1) Content of Foods in the U.S.
Food and Drug Administration's Total Diet Study. J Agric Food Chem 1995: 43: 1574-9.
VZ4): Booth SL, Davidson KW, Sadowski JA. Evaluation of an HPLC method for the determination ofphylloquinone (vitamin K1) in various food matrixes. J Agric Food Chem 1994: 42: 295-300.
VZ5): Walker FB. Myocardial infarction after diet-induced warfarin resistance. Arch Intern Med 1984:
144: 2089-90.
VZ6): Pedersen FM, Hamberg O, Hess K, Ovesen L. The effect of dietary vitamin K on warfarin-induced
anticoagulation. J Intern Med 1991: 229: 517-20.
VZ7): Ovesen L, Lyduch S, Idorn ML. The effect of a diet rich in brussels sprouts on warfarin
pharmacokinetics. Eur J Clin Pharmacol 1988: 33: 521-3.

P’¡“”5A,-./0*=>?8@A1BCDEFG8HI'J1$()*K<1KLM8NOS
1!"#$%&'(!)*+,(!)*-.(!PMID(!"#/0(!123456789:;<=>?@AB(!CD2<=>?@AB(!EFGH(!IJ(!KLMNOPQR(

PubMed!"#$%&'$()*K+,-./0*123456789:;<,-./0*=>?8@A1BCDEFG8HI'J1$()*K<1KLM8NO
Vitamin K: a practical guide to the dietary management of patients on warfarin.
Booth SL, Centurelli MA. Nutr Rev. 1999 Sep;57(9 Pt 1):288-96.
10568341

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E@ÂÃm#j‹z;H!"#$./'01,&grs45E«m;IBJ,K&5‰45`$@d•‘%&9:WVMV&‹d'(&RDA‹z;65-80 µg/¾N)RmeºM®…‰&IBJ,KNOPm;l-@d./'01,½5¸&STE«Qd”-*+,:-äM./-01“:;H!%&$!'()(*$!+,-./012$!Abstractor34567$./'01,½5STE«m;¾¿}M"ÀÁ&ÂÃÄdÅEIBJ,K§¨"·EÆÇQRÈIÉ•‹z;H./'01,½5¸&STyIBJ,KNOPm;-d./'01,&©ªÊËEÌgm;RÍdIBJ,K§¨"·&OPNÎÏm;†‡yz;HQ•QdIBJ,K@ÐÑ&IBJ,KÒÓhB,ÔÕE«QW-Ö‡M×ØNËRQWV;RÍdÙÚEÎÏm;l-@‹jMVHÛÜWd./'01,&©ªÊËEÝÞNßà9ádÀâãäNåæm;RÍ&†‡”qÏ&IBJ,K‰Nç…m;†‡yz;H

!"#$%&!"1): Shetty HG, Backhouse G, Bentley DP, Routledge PA. Effective reversal of warfarin-induced
excessive anticoagulation with low dose vitamin K1. Thromb Haemost 1992: 67(1): 13-5.
!"2)#Food and Nutrition Board. Recommended Dietary Allowance. 10th ed. Washington, DC: National
Academy of Sciences, 1989.
!"3)#Booth SL and Suttie JW. Dietary intake and adequacy of vitamin K. J Nutr 1998: 128: 785-8.
!"4)#Booth SL, Sadowski JA, Weihrauch JL, Ferland G. Vitami K1 (phylloquinone) content of foods: aprovisional table. J Food Compos Anal 1993: 6(2): 109-120.
!"5)#Ferland G, Sadowski JA. Vitamin K1 (phylloquinone) content of edible oils: effects of heating andlight exposure. J Agric Food Chem 1992: 40(10): 1869–1873.
!"6): Michaelson R, Kempin SJ, Navia B, Gold JW. Inhibition of the hypoprothrombinemic effect of
warfarin (Coumadin) by Ensure Plus, a dietary supplement. Clin bull 1980: 10(4): 171-172.

!"7): Lader E, Yang L, Clarke A. Warfarin dosage and vitamin K in Osmolite. Ann Int Med 1980: 93(2):373- 374.
!"8): Lee M, Schwartz RN, Sharifi R. Warfarin resistance and vitamin K. Ann Int Med 1981: 94(1):140-141.
!"9): Sorano GG, Biondi G, Conti M, Mameli G, Licheri D, Marongiu F. Controlled vitamin K content dietfor improving the management of poorly controlled anticoagulated patients: a clinical practice proposal.
Haemostasis 1993: 23(2):77-82.

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