The 51st NIPS International Symposium

Frontiers in
Epithelial Cell Biology
December 6-8, 2021

Organizers:
Mikio Furuse, National Institute for Physiological Sciences
Tetsuhisa Otani, National Institute for Physiological Sciences
Yasushi Izumi, National Institute for Physiological Sciences
Sachiko Fujiwara, National Institute for Physiological Sciences

Administrative Office:Yuichiro Kano, National Institute for Physiological Sciences
Tomomi Okayasu, National Institute for Physiological Sciences
5-1 Higashiyama Myodaiji, Okazaki, Aichi, Japan 444-8787
TEL: +81-564-59-5277; FAX: +81-564-59-5275
e-mail: furuse@nips.ac.jp
URL: https://www.nips.ac.jp/dcs/symposium51/

Program at a Glance
Time: JST: UTC+9:00
ththDecember 6 , Monday (Day 1)

December 7 , Tuesday (Day 2)

10:45
Opening remarks by Junichi Nabekura
10:50
Introduction by Mikio Furuse
11:00

11:00
Session 1
Chair: Ann Miller
Alpha Yap
Mikio Furuse
Kaoru Sugmiura
Makoto Sato

13:00

Session 3
Chair Alexander Ludwig
Sachiko Tsukita
Ann Miller
Yukako Oda
Akiharu Kubo
13:00

Break (1 hour)
14:00

Break (1 hour)
14:00

Poster session(Odd numbered posters)(Gather)
15:30

Poster session(Even numbered posters)(Gather)
15:30

Session 2
Chair: Alpha Yap
Parisa Kakanj
Shigenobu Yonemura
Junichi Ikenouchi
Alf Honigmann
17:30

Session 4
Chair: Tatsushi Igaki
Yusuke Toyama
Tsuyoshi Hirashima
Paolo Armando Gagliardi
Stefano DeRenzis
17:30

Social Hour
(Gather)Social Hour
(Gather)2thDecember 8 , Wednesday (Day 3)
11:00
Session 5
Chair: Shigenobu Yonemura
Elgin Korkmazhan
Mitsunori Fukuda
Alexander Ludwig
Akihiro Harada
13:00
Break (1 hour)
14:00
Session 6
Chair: Kaoru Sugimura
Erina Kuranaga
Tatsushi Igaki
Fanny Jaulin
15:45
Break (30 min)16:15Session 7
Chair: Erina Kuranaga
Markus Bleich
Minoru Takasato
Motoko Yanagita
18:00
Concluding remarks
18:30
Social Hour(Gather)3

Program
Time: JST: UTC+9:00
December 6th, Monday (Day 1)
10:45 Opening remarks
Junichi Nabekura (Director General, NIPS, Japan)
10:50 Introduction
Mikio Furuse (Organizer, NIPS, Japan)
Session 1
Chair: Ann Miller
11:00 S1-1
Mechanotransduction at adherens junctions: its role in epithelial
homeostasis
Alpha Yap (University of Queensland, Australia)
11:35 S1-2
Mechanisms of paracellular sealing at tricellular contacts invertebrate epithelial cells
Mikio Furuse (NIPS, Japan)
12:10 S1-3
Dissecting molecular and physical mechanisms underlying cell
rearrangement
Kaoru Sugimura (University of Tokyo, Japan)
12:45 S1-4 (P15)
Tiling mechanisms of the compound eye through geometricaltessellation
Makoto Sato (Kanazawa University, Japan)

4

13:00-14:00

Break

14:00 Poster session – Odd numbered posters (Gather)
Session 2
Chair: Alpha Yap
15:30 S2-1 (P22)
Autophagy suppression by TORC1 maintains epithelial plasma
membrane integrity
Parisa Kakanj (University of Cologne, Germany)
15:45 S2-2
Adjusting Tension sensitivity of -cateninmorphogenesis
Shigenobu Yonemura (Tokushima University, Japan)

forepithelial

16:20 S2-3
Roles of membrane lipids in tight junction formation
Junichi Ikenouchi (Kyushu University, Japan)
16:55 S2-4
The supra-molecular structure of the apical junctional complex in
MDCK cysts
Alf Honigmann (MPI-CBG, Germany)

17:30 Social Hour (Gather)5

December 7th, Tuesday (Day 2)
Session 3
Chair: Alexander Ludwig
11:00 S3-1
The tight-junction apical complex: A new point of view that
increases our understanding of epithelial barriers and biologicalsystems
Sachiko Tsukita (Teikyo University, Japan)
11:35 S3-2
Maintenance and remodeling of epithelial cell-cell junctions during
cell shape changes
Ann Miller (University of Michigan, USA)12:10 S3-3
The epidermal tight junction barrier maintaining homeostasis of theskin
Akiharu Kubo (Kobe University, Japan)
12:45 S3-4 (P14)
Anti-inflammatory peptides promote tissue-repair by reinforcing
epithelial barrier
Yukako Oda (Kyoto University, Japan)

13:00 – 14:00 Break

14:00 Poster session – Even numbered posters (Gather)6Session 4
Chair: Tatsushi Igaki
15:30 S4-1
Decoding the spatial pattern of apoptosis-induced compensatory
proliferation
Yusuke Toyama (Mechanobiology Institute, Singapore)
16:05 S4-2
Mechanochemical

feedback

controlincollective

epithelial

migration
Tsuyoshi Hirashima (Kyoto University, Japan)
16:40 S4-3 (P25)Collective ERK/Akt activity waves orchestratehomeostasis by driving apoptosis-induced survival
Paolo Armando Gagliardi (University of Bern, Switzerland)
16:55 S4-4
Engineering Morphogenesis with Optogenetics
Stefano DeRenzis (EMBL Heidelberg, Germany)

17:30 Social Hour (Gather)

7epithelialDecember 8th, Wednesday (Day 3)
Session 5
Chair: Shigenobu Yonemura
11:00 S5-1 (P19)
Dynamic yet strong: sliding anchors as novel organizers of the cellcortex
Elgin Korkmazhan (Stanford University, USA)
11:15 S5-2
Mechanisms of polarized exosome release from epithelial cells
Mitsunori Fukuda (Tohoku University, Japan)
11:50 S5-3
Organisation
andspatio-temporalcontrolof
theCrumbs-associated polarity network in mammalian epithelial cells
Alexander Ludwig (Nanyang Technological University, Singapore)
12:25 S5-4
Roles of Rabs and SNAREs in epithelial cell polarity in vivo
Akihiro Harada (Osaka University, Japan)

13:00 – 14:00 BreakSession 6
Chair: Kaoru Sugimura
14:00 S6-1
Mechanical perspective of collective cell movement in epithelial
morphogenesis
Erina Kuranaga (Tohoku University, Japan)

8

14:35 S6-2
Genetic dissection of cell competition: how to eliminate unfit
neighbors in the epithelium
Tatsushi Igaki (Kyoto University, Japan)
15:10 S6-3
Epithelial cell clusters undergo a new mode of collective migration
Fanny Jaulin (Gustave Roussy, France)

15:45 – 16:15 BreakSession 7
Chair: Erina Kuranaga
16:15 S7-1
New insights on the role of claudin-10 in renal tubular transport
function
Markus Bleich (Kiel University, Germany)
16:50 S7-2
Induction of 3D bladder epithelial organoids using the support ofsplanchnic mesoderm
Minoru Takasato (RIKEN BDR, Japan)
17:25 S7-3
Renal microenvironments regulating renal injury, inflammation andfibrosis
Motoko Yanagita (Kyoto University, Japan)

18:00 Concluding remarks
18:10 Social Hour (Gather)9

Poster Program
P01
Optogenetic relaxation of actomyosin contractility uncovers mechanisticroles of cortical tension during cytokinesis
Kei Yamamoto (NIBB, Japan)
P02
Image-based statistical inference of mechanical parameters governing
epithelial morphogenesis
Goshi Ogita (Kyoto University, Japan)
P03
Occludin and tricellulin regulate the complexity of tight junction strand
network and epithelial barrier function
Tomohito Higashi (Fukushima Medical University, Japan)
P04
Characterisation of Pals1 dynamics during epithelial polarity development
Eleanor Martin (Nanyang Technological University, Singapore)
P05
The effect of claudin-15 deletion on paracellular Na+ transport in thececum and large intestine
Wendy Hempstock (University of Shizuoka, Japan)
P06
Protective effects of flavonoids against weak UVB-induced barrier
dysfunction via suppressing nitric oxide production and mislocalization ofclaudin-1 in HaCaT cells
Yuta Yoshino (Gifu Pharmaceutical University, Japan)

10

P07
Functional rescue for disease-associated CFTR-mutations frequently
found in Japanese CF patients by the CFTR correctors for Caucasianmutants
Yoshiro Sohma (International University of Health and Welfare, Japan)
P08
The role of the paracellular barrier in stem cell homeostasis in theDrosophila gut
Yasushi Izumi (NIPS, Japan)
P09
Keratin intermediate filaments in mechanotransduction of keratinocytes
and the pathophysiology of epidermolysis bullosa simplex
Sachiko Fujiwara (NIPS, Japan)
P10
The roles of claudins and JAM-A in providing tight junction-dependent
mechanical resistanceThanh Phuong Nguyen (NIPS, Japan)
P11
Roles of the cytoskeleton in the accumulation of cholesterol at tightjunction regions
Kenta Shigetomi (Kyushu University, Japan)
P12
Tricellulin plays an essential role for the barrier function at tricellularjunctions by interacting with actomyosin
Yuma Cho (Kyushu University, Japan)
P13
Roles of Homer family proteins in the formation of circumferential actin
ring in epithelial cells
Ryoya Fujinaga (Kyushu University, Japan)

11P14 (S3-4)
Anti-inflammatory peptides promote tissue-repair by reinforcing epithelialbarrier
Yukako Oda (Kyoto University, Japan)
P15 (S1-4)
Tiling mechanisms of the compound eye through geometrical tessellation
Makoto Sato (Kanazawa University, Japan)
P16
Study on the expression of Angiotensin converting enzyme 2, ACE2 in the
primary culture of human nasal and bronchial epithelial cells
Kasane Yasuoka (Ritsumeikan University, Japan)
P17
De-wetting of cortical myosin-II facilitates the reconnection of junctions
during cell rearrangement
Keisuke Ikawa (University of Tokyo, Japan)P18TBA
Tara Finegan (Syracuse University, USA)P19 (S5-1)
Dynamic yet strong: sliding anchors as novel organizers of the cell cortex
Elgin Korkmazhan (Stanford University, USA)
P20
Epithelial adhesions modulate apical domain contraction to drive cell
shape change
Kenji Matsuzawa (Kyushu University, Japan)
P21
Roles of Ezrin in regulation of ciliary beating in airway ciliary cell
Kotoku Kawaguchi (Ritsumeikan University, Japan)
12

P22 (S2-1)
Autophagy suppression by TORC1 maintains epithelial plasma membrane
integrity
Parisa Kakanj (University of Cologne, Germany)
P23Linking epithelial morphogenesis and oncogenic PI3K/Akt signaling
Agne Frismantiene (University of Bern, Switzerland)P24
A unique mode of functional cell death in stratum granulosum cells,corneoptosis
Takeshi Matsui (Tokyo University of Technology)
P25 (S4-3)
Collective ERK/Akt activity waves orchestrate epithelial homeostasis bydriving apoptosis-induced survival
Paolo Armando Gagliardi (University of Bern, Switzerland)
P26
Competitive elimination of tight junction deficient cells regulate epithelial
barrier homeostasis
Tetsuhisa Otani (NIPS, Japan)
P27
Epithelial tissue compression is mediated by a novel lateral non canonical
E-Cadherin associated basal supra cellular acto-myosin cortex in
Drosophila pupal trachea
Rojalin Pradhan (National Institute of Science Education and Research, HBNI,India)
P28
Remodeling of the luminal epithelium of the uterus during implantation ofmouse embryos
Jun Sakurai (NIBB, Japan)
13

P29
mTORC2 suppresses cell death induced by hypoosmotic stress bypromoting sphingomyelin transport
Yumiko Ono (Kyushu University, Japan)
P30
Defects in Tricellular Junction
Competition
Haolin Xie (Kyoto University, Japan)

Triggers

Tumor-SuppressiveCell

P31
Research on the regulatory factor related to differentiation of multiciliated
ependymal cells
Takuya Hirao (Ritsumeikan University, Japan)
P32
Transcriptional profiles along cell programming into corneal epithelial
differentiation
Maria-Teresa Ortiz-Melo (Universidad Nacional Autonoma de Mexico, Mexico)

14