Curriculum Vitae with Publication List
update: July 27, 2024
Personal Data
Name:

Tsuyoshi MITA（美多Date of Birth:

August 09, 1976

Place of Birth:Tokyo, Japan

Gender:Male

Citizenship:

Japanese

Language:

English and Japanese剛）

Current Affiliation
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
Address:

Kita 21, Nishi 10, Kita-ku, Sapporo 001-0021, Japan

Job title:

Professor

URL:

https://www.icredd.hokudai.ac.jp/

Tel:+81-(0)11-706-9653

Fax:+81-(0)11-706-9655

E-mail:tmita@icredd.hokudai.ac.jp

ORCID:

0000-0002-6655-3439

ResearcherID:

D-7069-2012

Researchmap:

https://researchmap.jp/bbb/?lang=english

Education and Working Experiences
1996.4-2000.3:

Chemistry Department, Keio University, Supervisor: Prof. Tohru Yamada (BSc)

2000.4-2002.3:

Graduate School of Science and Technology, Keio University
Supervisor: Prof. Tohru Yamada (MSc)

2002.4-2004.3:

Ajinomoto Co., INC. (Process Research & Development, Pharmaceutical ResearchLaboratories in Pharmaceutical Company, Kawasaki, Japan)

2004.4-2007.3:

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Supervisor: Prof. Masakatsu Shibasaki (PhD)

2007.4-2009.3:

Department of Chemistry & Chemical Biology, Harvard University
Supervisor: Prof. Eric N. Jacobsen (Postdoctoral Fellow (JSPS Fellowship_SPD))2009.4-2019.3:

Faculty of Pharmaceutical Sciences, Hokkaido University(Assistant Professor in the Yoshihiro Sato’s group)2019.4-2023.3:

Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)(Specially Appointed Associate Professor)

2019.10-present: JST, ERATO “MAEDA Artificial Intelligence in Chemical Reaction Design andDiscovery Project” (Group leader in organic synthesis group)2023.4-present:

Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)(Professor)
1/22

2023.4-2024.3

Graduate School of Science, Kyoto University (Part-time Lecturer)

2023.10-2024.3:

Graduate School of Medical and Pharmaceutical Sciences, Chiba University (Part-

time Lecturer)
2024.4-present:

School of Advanced Science and Engineering, Waseda University (Part-time

Lecturer)
Membership
Pharmaceutical Society of Japan (PSJ), Chemical Society of Japan (CSJ), Society of Synthetic Organic
Chemistry of Japan (SSOCJ), American Chemical Society (ACS), Kinka Chemical SocietyAwards2007.3: The Representative of Graduating PhD Students, Faculty of Pharmaceutical Sciences
The University of Tokyo
2007:

JSPS Postdoctoral Fellowship (Superlative Postdoctoral Fellow (SPD))2009:

Tosoh Corporation Award in Synthetic Organic Chemistry, Japan2014:

Incentive Award in Synthetic Organic Chemistry, Japan2014:

Hokkaido University President’s Award for Research Excellence, Japan2016:

Chemist Award BCA in the MSD Life Science Foundation, Japan2018:

Lecture Award of ICPAC Langkawi 2018, Institut Kimia Malaysia

2019:

Young Researcher's Award in the Ube Industries Foundation, Japan

2020:

Hokkaido Science and Technology Incentive Award, Japan

Publications
1) Krishnan, C. G.; Takano, H.; Katsuyama, H.; Kanna, W.; Hayashi, H.; Mita, T.* “Strain-Releasing
Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones”
JACS Au 2024, 4, DOI: 10.1021/jacsau.4c00347.

2) Song, Y.; Hayashi, H.*; Mangaonkar, S.; Mita, T.* “Trans-Selective Carboxylative Cyclization of
1,6-Dienes Using the CO2 Radical Anion” Chem. Lett. 2024, 53, DOI: 10.1093/chemle/upae149.
2/223) Rawat, V. K.; Mita, T.* “Synthesis of Alkanoic Acids Using Carbon Dioxide through Catalytic CC Bond Forming Reactions” Science of Synthesis 2024, DOI: 10.1055/sos-SD-120-00326.

4) Mangaonkar, S. R.; Hayashi, H.; Kanna, W.; Debbarma, S.; Harabuchi, Y.; Maeda, S.*; Mita, T.*“γ‑Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion” Precis. Chem.
2024, 2 (3), 88-95.

5) Hayashi, H.*; Maeda, S; Mita, T.* “Quantum Chemical Calculations for Reaction Prediction in theDevelopment of Synthetic Methodologies” Chem. Sci. 2023, 14 (42), 11601-11616.

6) Rawat, V. K.; Hayashi, H.; Katsuyama, H.; Mangaonkar, S. R.; Mita, T.* “Revisiting theElectrochemical Carboxylation of Naphthalene with CO2: Selective Monocarboxylation of 2Substituted Naphthalenes” Org. Lett. 2023, 25 (23), 4231-4235.
3/22

7) Takano, H.; Katsuyama, H.; Hayashi, H.; Harukawa, M.; Tsurui, M.; Shoji, S.; Hasegawa, Y.;
Maeda, S.; Mita, T.* “Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped
Diphosphine Ligands” Angew. Chem., Int. Ed. 2023, 62 (23), e202303435.

8) Mangaonkar, S. R.; Hayashi, H.; Takano, H.; Kanna, W.; Maeda, S.; Mita, T.* “Photoredox/HATCatalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics”
ACS Catal. 2023, 13 (4), 2482-2488.

9) Harabuchi, Y.*; Hayashi, H.; Takano, H.; Mita, T.; Maeda, S.* “Oxidation and Reduction Pathways
in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction” Angew. Chem., Int.
Ed. 2023, 62 (1), e202211936.

10) Maeda, S.*; Harabuchi, Y.; Hayashi, H.; Mita, T.* “Toward Ab Initio Reaction Discovery Using
the Artificial Force Induced Reaction Method” Annu. Rev. Phys. Chem. 2023, 74, 287-311.
4/2211) Mita, T.*; Takano, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Houk, K. N.; Maeda, S.* “Predictionof High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex
Synthetic Targets” J. Am. Chem. Soc. 2022, 144 (50), 22985-23000.

12) Takano, H.; Katsuyama, H.; Hayashi, H.; Kanna, W.; Harabuchi, Y.; Maeda, S.*; Mita, T.* “A
Theory-driven Synthesis of Symmetric and Unsymmetric 1,2-Bis(diphenylphosphino)ethane
Analogues via Radical Difunctionalization of Ethylene” Nat. Commun. 2022, 13, 7034.

13) Hayashi, H.; Katsuyama, H.; Takano, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* “In Silico Reaction
Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines” Nat.
Synth. 2022, 1 (10), 804-814.

14) 美多 剛,* 樋口 裕紀, 佐藤 美洋* “π-アリルパラジウムの極性転換による二酸化炭素を用いた触媒的カルボキシル化の開発” 有機合成化学協会誌 2022, 80 (9), 806-816 (written in
Japanese).

5/2215) You, Y.; Kanna, W.; Takano, H.; Hayashi, H.; Maeda, S.*; Mita, T.* “Electrochemical Dearomative
Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials” J. Am. Chem. Soc.
2022, 144 (8), 3685-3695.

16) You, Y.; Mita. T.* “Recent Advances in the Catalytic Umpolung Carboxylation of Allylic Alcohol
Derivatives with Carbon Dioxide” Asian J. Org. Chem. 2022, 11 (5), e202200082.

17) 道上 健一, 美多 剛,* 佐藤 美洋* “末端アルケンを求核剤とするカルボニル化合物の触媒的アリル化反応” 有機合成化学協会誌 2022, 80 (3), 210-221 (written in Japanese).

18) Maeda, S.*; Harabuchi, Y.; Hasegawa, T.; Suzuki, K.; Mita, T. “Reactivity Prediction throughQuantum Chemical Calculations” AsiaChem Magazine 2021, 2 (1), 56-63.
19) Takano, H.; You, Y.; Hayashi, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* “Radical
Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective
Incorporation of Two Molecules of Ethylene” ACS Omega 2021, 6 (49), 33846-33854.
6/2220) Kanna, W.; Harabuchi, Y.; Takano, H.; Hayashi, H.; Maeda, S.*; Mita, T.* “Carboxylation of a
Palladacycle Formed via C(sp3)–H Activation: Theory-Driven Reaction Design” Chem. Asian J.
2021, 16 (24), 4072-4080.

21) Hayashi, H.; Takano, H.; Katsuyama, H.; Harabuchi, Y.; Maeda, S.*; Mita, T.* “Synthesis ofDifluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design,
Scope, and Application” Chem. Eur. J. 2021, 27 (39), 10040-10047.

22) Matsuoka, K.; Komami, N.; Kojima, M.; Mita, T.; Suzuki, K.; Maeda, S.; Yoshino, T.*; Matsunaga,
S.* “Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using IodineTris(trifluoroacetate)” J. Am. Chem. Soc. 2021, 143 (1), 103-108.

23) Mita, T.*; Harabuchi, Y.; Maeda, S.* “Discovery of a Synthesis Method for a Difluoroglycine
Derivative Based on a Path Generated by Quantum Chemical Calculations” Chem. Sci. 2020, 11(29), 7569-7577.
7/2224) Shishido, R.; Uesugi, M.; Takahashi, R.; Mita, T.; Ishiyama, T.; Kubota, K.*; Ito, H.* “General
Synthesis of Trialkyl- and Dialkylarylsilylboranes: Versatile Silicon Nucleophiles in Organic
Synthesis” J. Am. Chem. Soc. 2020, 142 (33), 14125-14133.

25) Mita, T.*; Uchiyama, M.; Sato, Y.* “Catalytic Intramolecular Coupling of Ketoalkenes by Allylic
C(sp3)-H Bond Cleavage: Synthesis of Five- and Six-Membered Carbocyclic Compounds” Adv.
Synth. Catal. 2020, 362 (6), 1275-1280.

26) Mita, T.*; Sato, Y.* “Syntheses of α-Amino Acids by Using CO2 as a C1 Source” Chem. Asian J.
2019, 14 (12), 2038-2047.

27) Mita, T.*; Masutani, H.; Ishii, S.; Sato, Y.* “Catalytic Carboxylation of Heteroaromatic
Compounds: Double and Single Carboxylation with CO2” Synlett 2019, 30 (7), 841-844.

8/2228) Mita, T.*; Ishii, S.; Higuchi, Y.; Sato, Y.* “Pd-Catalyzed Dearomative Carboxylation ofIndolylmethanol Derivatives” Org. Lett. 2018, 20 (23), 7603-7606.

29) Mita, T.*; Uchiyama, M.; Michigami, K.; Sato, Y.* “Cobalt-Catalyzed Nucleophilic Addition of
the Allylic C(sp3)-H Bond of Simple Alkenes to Ketones” Beilstein J. Org. Chem. 2018, 14, 20122017.

30) Mita, T.*; Hanagata, S.; Michigami, K.; Sato, Y.* “Co-Catalyzed Direct Addition of Allylic C(sp3)H Bonds to Ketones” Org. Lett. 2017, 19 (21), 5876-5879.【highlighted by Synfacts 2018, 14, 74.】31) Michigami, K.; Mita, T.*; Sato, Y.* “Cobalt-Catalyzed Allylic C(sp3)-H Carboxylation with CO2”
J. Am. Chem. Soc. 2017, 139 (17), 6094-6097.

32) Higuchi, Y.; Mita, T.*; Sato, Y.* “Palladium-Catalyzed Intramolecular Arylative Carboxylation ofAllenes with CO2 for the Construction of 3‑Substituted Indole-2-Carboxylic Acids” Org. Lett. 2017,19 (10), 2710-2713.
9/2233) Mita, T.*; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids through Carboxylationof Ammonium Ylides with CO2 Followed by Alkyl Migration” J. Org. Chem. 2016, 81 (12), 52365243.

34) Mita, T.*; Tanaka, H.; Higuchi, Y.; Sato, Y.* “Palladium-Catalyzed Carboxylation of ActivatedVinylcyclopropanes with CO2” Org. Lett. 2016, 18 (11), 2754-2757.

35) Mita, T.*; Saito, K.; Sugawara, M.; Sato, Y.* “Stereoretentive Addition of N-tert-Butylsulfonyl-αAmido Silanes to Aldehydes, Ketones, α,β-Unsaturated Esters, and Imines” Chem. Asian. J. 2016,
11 (10), 1528-1531.

36) Mita, T.*; Higuchi, Y.; Sato, Y.* “Highly Regioselective Palladium-Catalyzed Carboxylation ofAllylic Alcohols with CO2” Chem. Eur. J. 2015, 21 (46), 16391-16394.

37) Mita, T.*; Suga, K.; Sato, K.; Sato, Y.* “A Strained Disilane-Promoted Carboxylation of Organic
Halides with CO2 under Transition-Metal-Free Conditions” Org. Lett. 2015, 17 (21), 5276-5279.
10/2238) 美多 剛* “C(sp3)-H 結合のシリル化およびトリホウ素化、続く二酸化炭素によるカルボキ
シル化の開発” 有機合成化学協会誌 2015, 73 (8), 810-820 (written in Japanese).

39) Mita, T.*; Sugawara, M.; Saito, K.; Sato, Y.* “Catalytic Enantioselective Silylation of NSulfonylimines: Asymmetric Synthesis of α-Amino Acids from CO2 via Stereospecific
Carboxylation of α-Amino Silanes” Org. Lett. 2014, 16 (11), 3028-3031.【highlighted by Synfacts
2014, 10, 839.】40) Mita, T.*; Tanaka, H.; Michigami, K.; Sato, Y.* “Ruthenium-Catalyzed C-H Silylation of 1Arylpyrazole Derivatives and Fluoride-Mediated Carboxylation: Use of Two Nitrogen Atoms of
the Pyrazole Group” Synlett 2014, 25 (9), 1291-1294.

41) Mita, T.*; Chen, J.; Sato, Y.* “Synthesis of Arylglycines from CO2 through α-Amino
Organomanganese Species” Org. Lett. 2014, 16 (8), 2200-2203.【highlighted by Synfacts 2014,
10, 742.】42) Mita, T.*; Higuchi, Y.; Sato, Y.* “Carboxylation with CO2 via Brook Rearrangement: Preparationof α-Hydroxy Acid Derivatives” Org. Lett. 2014, 16 (1), 14-17.

11/2243) Mita, T.*; Michigami, K.; Sato, Y.* “Iridium- and Rhodium-Catalyzed Dehydrogenative
Silylations of C(sp3)-H Bonds Adjacent to a Nitrogen Atom Using Hydrosilanes” Chem. Asian. J.
2013, 8 (12), 2970-2973.

44) Mita, T.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids from CO2 Using Bismetal Reagents” J.
Synth. Org. Chem., Jpn. 2013, 71 (11), 1163-1171.

45) Mita, T.*; Ikeda, Y.; Michigami, K.; Sato, Y.* “Iridium-Catalyzed Triple C(sp3)-H Borylations:
Construction of Triborylated Sp3-Carbon Centers” Chem. Commun. 2013, 49 (49), 5601-5603.

46) Mita, T.*; Higuchi, Y.; Sato, Y.* “One-Step Synthesis of Racemic α-Amino Acids from Aldehydes,
Amine Components, and Gaseous CO2 by the Aid of a Bismetal Reagent” Chem. Eur. J. 2013, 19(3), 1123-1128.

47) Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids from CO2
Using a Bismetal Reagent with Si-B Bond” Org. Lett. 2012, 14 (24), 6202-6205.

48) Mita, T.*; Michigami, K.; Sato, Y.* “Sequential Protocol for C(sp3)-H Carboxylation with CO2:
12/22

Transition Metal-Catalyzed Benzylic C-H Silylation and Fluoride-Mediated Carboxylation” Org.
Lett. 2012, 14 (13), 3462-3465.【highlighted by Synfacts 2012, 8, 1132.】49) Mita, T.*; Sugawara, M.; Hasegawa, H.; Sato, Y.* “Synthesis of Arylglycine and Mandelic Acid
Derivatives through Carboxylations of α-Amido and α-Acetoxy Stannanes with Carbon Dioxide”
J. Org. Chem. 2012, 77 (5), 2159-2168.

50) Mita, T.*; Higuchi, Y.; Sato, Y.* “Convenient and Practical Synthesis of α-Amido Stannanes”
Synthesis 2012, 44 (2), 194-200. [PSP (Practical Synthetic Procedures)-article]51) Mita, T.*; Higuchi, Y.; Sato, Y.* “Practical Synthesis of N-Boc- and N-Cbz-α-Amido Stannanes
from α-Amido Sulfones Using TMSSnBu3 and CsF” Org. Lett. 2011, 13 (9), 2354-2357.
【highlighted by Synfacts 2011, 7, 772.】

52) Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids from Imines
through CO2 Incorporation: An Alternative Method for Strecker Synthesis” Angew. Chem., Int. Ed.
2011, 50 (6), 1393-1396.

53) Mita, T.; Jacobsen, E. N.* “Bifunctional Asymmetric Catalysis with Hydrogen Chloride:
Enantioselective Ring-Opening of Aziridines Catalyzed by a Phosphinothiourea” Synlett 2009,2009 (10), 1680-1684.
13/2254) Fujimori, I.; Mita, T.; Maki, K.; Shiro, M.; Sato, A.; Furusho, S.; Kanai, M.*; Shibasaki, M.*“Toward a Rational Design of the Assembly Structure of Polymetallic Asymmetric Catalysts:
Design, Synthesis, and Evaluation of New Chiral Ligands for Catalytic Asymmetric Cyanation
Reactions” Tetrahedron 2007, 63 (26), 5820-5831.
55) Mita, T.; Fukuda, N.; Roca, F. X.; Kanai, M.*; Shibasaki, M.* “Second Generation Catalytic
Asymmetric Synthesis of Tamiflu: Allylic Substitution Route” Org. Lett. 2007, 9 (2), 259-262.
【highlighted by Synfacts 2007, 3, 567.】
56) Fujimori, I.; Mita, T.; Maki, K.; Shiro, M.; Sato, A.; Furusho, S.; Kanai, M.*; Shibasaki, M.* “KeyRole of the Lewis Base Position in Asymmetric Bifunctional Catalysis: Design and Evaluation ofa New Ligand for Chiral Polymetallic Catalysts” J. Am. Chem. Soc. 2006, 128 (51), 16438-16439.
【highlighted by Synfacts 2007, 3, 285.】
57) Kato, N.; Mita, T.; Kanai, M.*; Therrien, B.; Kawano, M.; Yamaguchi, K.; Danjo, H.; Sei, Y.; Sato,A.; Furusho, S.; Shibasaki, M.* “Assembly State of Catalytic Modules as Chiral Switches in
Asymmetric Strecker Amino Acid Synthesis” J. Am. Chem. Soc. 2006, 128 (21), 6768-6769.
58) Fukuta, Y.; Mita, T.; Fukuda, N.; Kanai, M.*; Shibasaki, M.* “De Novo Synthesis of Tamiflu via
a Catalytic Enantioselective Ring-Opening of meso-Aziridines with TMSN3” J. Am. Chem. Soc.
2006, 128 (19), 6312-6313.【highlighted by Synfacts 2006, 2, 975.】
59) Mita, T.; Fujimori, I.; Wada, R.; Wen, J.; Kanai, M.*; Shibasaki, M.* “Catalytic Enantioselective
Desymmetrization of meso-N-Acylaziridines with TMSCN” J. Am. Chem. Soc. 2005, 127 (32),11252-11253.【highlighted by Synfacts 2005, 1, 322.】60) 毛塚 智子, 美多 剛, 岩倉 いずみ, 池野 健人, 山田 徹* “光学活性コバルト錯体をルイス酸として用いる触媒的不斉合成反応” 有機合成化学協会誌 2005, 63 (6), 604-615 (written in
Japanese).
61) Mita, T.; Sasaki, K.; Kanai, M.*; Shibasaki, M.* “Catalytic Enantioselective Conjugate Additionof Cyanide to α,β-Unsaturated N-Acylpyrroles” J. Am. Chem. Soc. 2005, 127 (2), 514-515.
62) Kezuka, S.; Ohtsuki, N.; Mita, T.; Kogami, Y.; Ashizawa, T.; Ikeno, T.; Yamada, T.*“Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with α,β-Unsaturated
Aldehydes Catalyzed by Cationic 3-Oxobutylideneaminatocobalt(III) Complexes” Bull. Chem.
Soc. Jpn. 2003, 76 (11), 2197-2207.
63) Ohtsuki, N.; Kezuka, S.; Kogami, Y.; Mita, T.; Ashizawa, T.; Ikeno, T.; Yamada, T.*“Enantioselective 1,3-Dipolar Cycloaddition Reactions between Nitrones and α-Substituted α,βUnsaturated Aldehydes Catalyzed by Chiral Cationic Cobalt(III) Complexes” Synthesis 2003, 2003
(9), 1462-1466.
64) Mita, T.; Ohtsuki, N.; Ikeno, T.; Yamada, T.* “Enantioselective 1,3-Dipolar Cycloaddition of
Nitrones Catalyzed by Optically Active Cationic Cobalt(III) Complexes” Org. Lett. 2002, 4 (15),2457-2460.
65) Kezuka,S.;

Mita, T.;

Ohtsuki, N.; Ikeno, T.; Yamada, T.*“Highly Active 3-

Oxobutylideneaminatocobalt Complex Catalysts for an Enantioselective Hetero Diels-Alder
Reaction” Bull. Chem. Soc. Jpn. 2001, 74 (7), 1333-1342.
66) Kezuka, S.; Mita, T.; Ohtsuki, N.; Ikeno, T.; Yamada, T.* “Optically Active Cationic Cobalt(III)14/22

Complexes: Highly Efficient Catalysts for Enantioselective Hetero Diels-Alder Reaction” Chem.
Lett. 2000, 29 (7), 824-825.
67) Yamada, T.*; Kezuka, S.; Mita, T.; Ikeno, T. “Optically Active Aldiminato Cobalt(II) Complex
Catalyst for Enantioselective Hetero Diels-Alder Reaction” Heterocycles 2000, 52 (3), 1041-1045.
Book Chapters
1) 美多 剛, 佐藤 美洋 “第 7 節 二酸化炭素を一炭素源として用いる α-アミノ酸の化学合成” 二酸化炭素を用いた化学品製造技術 2016, pp 132-145, Ed. 杉本 裕, S&T 出版.
2) Shibasaki, M.; Kanai, M.; Mita, T. “Chapter 1 The Catalytic Asymmetric Strecker Reaction”
Organic Reactions 2008, 70, pp 1-119, Ed. Larry E. Overman, John Wiley & Sons.
3) 美多 剛 “合格体験記 大学院でもう一度研究を！” 医歯薬農学系のための大学院の歩き方 2006, pp.170-171, Ed. 東京図書編集部, 東京図書.
Commentaries
1) 美多 剛, “安定なヘテロ芳香環に CO2 を導入する新反応の開発” 化学と工業 2024, 77 (1),28-30.
2) 美多 剛, “おらが春 辰年生れ大いに語る” 近畿化学工業界 2024, 76 (1), 22.
3) 美 多 剛 , “ 犠 牲 陽 極 を 使 用 し な い 芳 香 族 化 合 物 の 電 解 C-H カ ル ボ キ シ ル 化 ”
Organometallic News 2023, (3), 108.
4) 美多 剛, 前田 理 “超の世界 反応経路自動探索法で有機化合物の出発原料をゼロから
予測 －量子化学的逆合成解析により高収率な化学反応を予測－” 自動車技術 2023, 77(10), 110-111.
5) 美多 剛 “書評『有機化学のための量子化学計算入門：Gaussian の基本と有効活用のヒント』” 理論化学会誌 フロンティア 2023, 5 (3), 217-218.
6) 原渕 祐, 林 裕樹, 髙野 秀明, 美多 剛 “量子化学計算に基づく反応経路ネットワークの構築と有機合成反応開発への展開” アンサンブル 2023, 25 (1), 34-40.
7) 美多 剛 “極性転換” 十字路 有機合成化学協会誌 2022, 80 (9), 871.
8) 美多 剛, “合成化学実験のように反応条件を自在に変えて計算できる日を夢見て！” フォーラム, 量子化学探索研究所 (IQCE), 2021 年 4 月号.
9) 美多 剛, “計算科学による α-アミノ酸の合成経路予測と実験科学による具現化” 月刊 機

能材料 2020, 40 (11), 23-32.
10) 美多 剛, 佐藤 美洋 “二酸化炭素を炭素資源とした有機合成 -アリル遷移金属種を用いた触媒的カルボキシル化-” 現代化学 2019, 578 (5), 64-69.
11) Mita, T. “Transition Metal-Promoted Carboxylation of Terminal Alkynes with CO2” Mini-Reviewsin Organic Chemistry 2019, 16 (5), 406-409.
12) 美多 剛, 佐藤 美洋 “二酸化炭素固定化反応の新手法の開発 -反応性の低い C(sp3)-H 結合の切断を伴う触媒的カルボキシル化-” 今日の話題 化学と生物 2018, 56 (6), 381-383.
13) 美多 剛 “二酸化炭素から飽和脂肪酸を合成 遠隔カルボキシル化による新手法” 注目の論文 月刊 化学 2017, 72 (8), 62-63.
14) 美多 剛 “ビスメタル化合物” 十字路 有機合成化学協会誌 2015, 73 (8), 850.
15/2215) 美多 剛 “有機合成化学に用いるスズ試薬 –比較的安定で反応性に富む金属。有機スズ(IV)には毒性あり。–” 講座: 身近な元素の世界 化学と教育 2014, 62 (8), 400-403.
16) 美多 剛 “π-アリルイリジウムとエナミンの共同作用による 4 つの立体異性体の作り分
け” Topics (化学系薬学) ファルマシア, 2014, 50 (1), 62.
17) 柴崎 正勝, 金井 求, 福田 展久, 美多 剛 “タミフルの新合成法ができた！不斉触媒が拓く安定供給の道” 月刊 化学 2006, 61 (7), 12-17.
Patents
1) 美多 剛, 前田 理, 髙野 秀明“化合物の新規製造方法、新規化合物および金属触媒”
PCT/JP2022/ 30598, 2022 年 8 月 10 日 PCT 出願.
2) 美多 剛、前田 理、髙野秀明 “化合物の新規製造方法、新規化合物および金属触媒”特願 2021-131481, 2021 年 8 月 11 日出願.
3) Sato, Y.; Mita, T.; Miyaji, N. “Method for Producing α-Amino Acid Salt” No. 5794569, 2011 年 9
月 13 日出願.
4) Sato, Y.; Mita, T.; Miyaji, N. “Manufacturing Method for α-Hydroxy Acid Salt” No. 5747740, 2011年 8 月 30 日出願.
5) Haga, K.; Mita, T.; Hirasawa, S.; Tatara, A.; Yamanaka, N.; Yamanaka, J.; Okado, K.; Niwa, S.
“Method for Producing Lactam Compound and Production Intermediate Thereof” WO2008139576(A1), 2007 年 4 月 27 日国際出願.
6) Shibasaki, M.; Kanai, M.; Mita, T.; Fukuta, Y. “α,β-Unsaturated Cyclohexanone Derivative,
Process for Producing the Same, and Process for Producing Intermediate therefor”
WO2007099843 (A1), 2007 年 2 月 22 日国際出願.
7) Shibasaki, M.; Kanai, M.; Mita, T. “Method for Enantioselectively Preparing β-Cyanocarboxylic
Acid Derivative from α,β-Unsaturated Carboxylic Acid Derivative and Catalyst Used in the
Method” JP2006151839 (A), 2004 年 11 月 26 日出願.
Invited Lectures
1) 美多 剛 “量子化学計算が先導する新反応開発” 長崎, 日本プロセス化学会2024サマー
シンポジウム, 長崎, 長崎ブリックホール, 2024年7月4日-5日.
2) Mita, T. “Development of New Chemical Reactions Based on Quantum Chemical Calculations”
International Joint Symposium 2023 on Synthetic Organic Chemistry, 兵庫, 淡路夢舞台国際会
議場, 2023年12月6日-8日.
3) 美多 剛 “量子化学計算を活用した反応経路設計とその実現－現実世界との乖離を乗り越えて” 京都大学大学院理学研究科・特別講演会, 京都, 2023年11月16日.
4) 美多 剛 “ペリ環状反応－Woodward-Hoffmann則の理解と応用” 京都大学大学院理学研
究科・化学特別講義, 京都, 2023年11月15日-16日（京都大学大学院理学研究科・非常勤講師）.
5) 美多 剛 “ペリ環状反応－Woodward-Hoffmann則の理解と応用” 千葉大学大学院医学薬学府・薬化学特論, 千葉, 2023年11月10日（千葉大学大学院医学薬学府・非常勤講師）.
6) 美多 剛 “量子化学計算によるCO2ラジカルアニオンカルボキシル化の設計” 第132回触16/22

媒討論会, 北海道大学, 札幌, 2023年9月15日.
7) Mita, T. “AFIR-Based Reaction Design and Realization: Three-component Reactions using
Difluorocarbene and Free Radicals” The 5th Conference of Theory and Applications ofComputational Chemistry (TACC2023), 北海道大学, 札幌, 2023年9月9日.
8) 美多 剛 “反応経路自動探索法を用いた新反応の設計とその実現－挑戦と今後の課題”
第 35 回万有札幌シンポジウム, 北海道大学, 札幌, 2023 年 7 月 1 日.
9) Mita, T. “Transition-Metal-Catalyzed C(sp3)–H Carboxylation of CO2” The 7th International
Symposium on Catalysis and Chemical Engineering (CCE-2023), オンライン, 2023 年 2 月 20
日-23 日.
10) Mita, T. “Theory-Driven Organic Synthesis” The 5th ICReDD International Symposium, オンラ
イン, 2023 年 1 月 10 日.
11) 美多 剛 “計算化学主導の新反応開発” 徳島大学・特別講演会, 徳島大学, 徳島, 2022 年
10 月 24 日.
12) Mita, T. “Calculation-Based Reaction Design: Three-Component Reactions Using Difluorocarbene”
Joint Symposium of S-Membrane Project and F-Material Project at Gunma University, 群馬大学,
桐生, 2022 年 10 月 21 日.
13) Mita, T. “Electrochemical Dearomative Carboxylations of Heteroaromatics with Highly Negative
Reduction Potentials” Carbon Chemistry and Materials (CCM-2022), オンライン, 2022 年 10 月
10 日-12 日.
14) 美多 剛 “Transition-Metal-Catalyzed Carboxylation of C(sp3)–H bonds with CO2” 錯体化学会
第 72 回討論会, 九州大学伊都キャンパス, 福岡, 2022 年 9 月 26 日-28 日.
15) 美多 剛 “量子化学計算を使った新しい分子変換反応のみつけ方 - 挑戦と今後の課題”
化学反応経路探索のニューフロンティア 2021, オンライン, 札幌, 2021 年 9 月 22 日.
16) 美多 剛 “計算科学を活用した有機合成” 日本質量分析学会 第 30 回北海道談話会・講演会, オンライン, 2021 年 8 月 3 日.
17) Mita, T. “Theory-Driven Approach to Chemical Synthesis of Difluoroglycine Derivatives and Its
Application” Joint Symposium of Engineering & Information Science & WPI-ICReDD in
Hokkaido University, オンライン, 2021 年 4 月 26 日.
18) 美多 剛 “α,α-ジフルオログリシン誘導体の化学合成とその応用” 第 6 回北大・部局横断
シンポジウム 若手研究者による生命と物質の融合を目指して！, オンライン, 2020 年 10
月 19 日.
19) 美多 剛 “二酸化炭素を炭素資源とした有機合成：α-アミノ酸の化学合成およびアリル金属種のカルボキシル化” 第 7 回柴﨑セミナー, 微生物化学研究所, 東京都品川区, 2019 年
9 月 21 日.
20) Mita, T. “Palladium-Catalyzed Allylic Carboxylation with Carbon Dioxide” Asia Pacific Society
for Materials Research 2019 Annual Meeting, Sapporo Convention Center, Sapporo, 2019 月 7 月
26 日-29 日.
21) Mita, T. “Cobalt(I)-Catalyzed Direct Addition of Allylic C(sp3)–H Bonds to Carbonyl Electrophiles”

Hokkaido Summer Symposium 2019 on Catalysis for Organic Synthesis, 北海道大学学術交流
会館, 札幌, 2019 年 7 月 1 日-2 日.
17/2222) 美多 剛 “二酸化炭素を用いた有機合成：α-アミノ酸の化学合成および遷移金属を駆使した触媒的カルボキシル化” 早稲田大学先進理工学部化学・生命化学科, 東京都新宿区,
2018 年 12 月 21 日.
23) Mita, T. “New Strategies for Carbon Dioxide Incorporation through C–C Bond Forming Process”
南洋理工大学理学院化学生物化学科, Singapore, 2018 年 11 月 5 日.
24) Mita, T. “Palladium-Catalyzed Dearomative Carboxylation of Indole Derivatives” International
Congress on Pure & Applied Chemistry (ICPAC) Langkawi 2018, Langkawi, Malaysia, 2018 年
10 月 30 日-11 月 2 日.
25) 美多 剛 “コバルト触媒によるアリル位 C(sp3)-H 結合の切断と求電子剤との反応” 第 5回辰巳午会化学シンポジウム, 北海道大学大学院地球環境科学研究院, 札幌, 2018 年 8 月
18 日-19 日.
26) Mita, T. “Development of Novel Carboxylation Reactions with Carbon Dioxide through C-C Bond
Formation” 国立中山大学化学科, 高雄, 台湾, 2018 年 4 月 2 日.
27) Mita, T. “Cobalt-Catalyzed Allylic C(sp3)-H Additions to Low Reactive Carbonyl Compounds,
CO2 and Ketones” International Congress on Pure & Applied Chemistry (ICPAC) 2018, Sakhalay
Angkor Resort & Spa, Siem Reap, Cambodia, 2018 年 3 月 7-10 日.
28) 美多 剛 “C(sp3)-H 結合切断による求核的アリルコバルト種の生成と求電子剤との反応”
第 50 回有機金属若手の会夏の学校, 定山渓万世閣ホテルミリオーネ, 札幌, 2017 年 8 月
7 日-9 日.
29) 美 多 剛 “Synthesis of α-Amino Acids from Carbon Dioxide” The 19th HU-SNU Joint
Symposium, 北海道大学薬学部, 札幌, 2016 年 11 月 24 日.
30) 美多 剛 “二酸化炭素を用いた α-アミノ酸の化学合成” 第 10 回プロセス化学ラウンジ,
和光純薬工業㈱湯河原研修所, 静岡, 2015 年 12 月 4-5 日.
31) 美多 剛 “二酸化炭素を一炭素源として用いた新規カルボキシル化反応の開発” 第 32 回
有機合成化学セミナー奨励賞受賞講演, ニューウェルシティ湯河原, 静岡, 2015 年 9 月
15-17 日.
32) Mita, T.; Sugawara, M.; Chen, J.; Higuchi, Y.; Sato, Y. “One-Pot Synthesis of α-Amino Acids from
CO2 and Imine Equivalents” Symposium on Organic Chemistry-Royal Society of Chemistry
Roadshow, 東北大学青葉山キャンパス, 仙台, 2015 年 6 月 1 日.
33) 美多 剛 “二酸化炭素ガス、フッ化セシウム、および Sn、Si、B を用いる有機合成: α-アミノ酸のワンポット合成、並びに触媒的 C-H カルボキシル化の開発” 若手研究者のための有機化学札幌セミナー, 北海道大学農学部, 札幌, 2012 年 11 月 26 日.
34) 美多 剛 “ハーバード大学での生活” 特別講演会, 慶應義塾大学理工学部, 横浜, 2008 年
8 月 23 日.
Research Grant
Grants-in Aid for Scientific Research (KAKENHI) (Researcher Number: 00548183)
1) Grant-in-Aid for Transformative Research Areas A (Digitalization-driven Transformative Organic
Synthesis (Digi-TOS)
Research theme:

Development of Photo-Digital Carboxylation Reaction by Fine Bubble Gas
18/22

Flow
Person in charge:

Tsuyoshi MITA

Duration of research: 2024-2025
Budget distribution:

6,400,000 yen

2) Grant-in-Aid for Scientific Research B
Research theme:

Expansion of MHAT/RPC Chemistry

Person in charge:

Hiroki SHIGEHISA

Duration of research: 2023-2027
Budget distribution:

1,500,000 yen

3) Grant-in-Aid for Transformative Research Areas A (Digitalization-driven Transformative Organic
Synthesis (Digi-TOS)
Research theme:

Selective and High-Yielding Carboxylations Based on Information Science

Person in charge:

Tsuyoshi MITA

Duration of research: 2022-2023
Budget distribution:

6,200,000 yen

4) Grant-in-Aid for Scientific Research B
Research theme:

Development of Novel CO2 Fixation Reactions Guided by Quantum
Chemical Calculations

Person in charge:

Tsuyoshi MITA

Duration of research: 2022-2025
Budget distribution:

13,400,000 yen

5) Grant-in-Aid for Challenging Research (Exploratory)
Research theme:

Proposing the Reaction Pathway of a New Radical Transformation andValidation by Synthetic Organic Chemistry

Person in charge:

Tsuyoshi MITA

Duration of research: 2021-2022
Budget distribution:

5,000,000 yen

6) Grant-in-Aid for Scientific Research C
Research theme:

Catalytic Multi-Carboxylation Using CO2

Person in charge:

Tsuyoshi MITA

Duration of research: 2018-2020
Budget distribution:

3,400,000 yen

7) Grant-in-Aid for Scientific Research C
Research theme:

Catalytic and Direct Carboxylation of C(sp3)-H Bonds with CO2

Person in charge:

Tsuyoshi MITA

Duration of research: 2014-2016
Budget distribution:

4,000,000 yen

8) Grant-in-Aid for Young Scientist B
Research theme:

Catalytic and Asymmetric Synthesis of α-Amino Acids from Imines and
CO2
19/22

Person in charge:

Tsuyoshi MITA

Duration of research: 2012-2013
Budget distribution:

3,600,000 yen

9) Grant-in-Aid for Young Scientist B
Research theme:

Synthesis of α-Amino Acids Using CO2 as a C1 Source

Person in charge:

Tsuyoshi MITA

Duration of research: 2010-2011
Budget distribution:

3,100,000 yen

10) Grant-in-Aid for Research Activity Start-Up
Research theme:

Synthesis of α-Amino Acids from CO2 Using a Nickel Catalyst

Person in charge:

Tsuyoshi MITA

Duration of research: 2009
Budget distribution:

1,070,000 yen

Other Funds
11) Tokyo Ohka Foundation for the Promotion of Science and Technology
Research theme:

Development of a Novel Synthesis Method for Lactones and Lactams Using
CO2 Radical Anions

Person in charge:

Tsuyoshi MITA

Duration of research: 2024
Budget distribution:

1,500,000 yen

12) The Naito Foundation
Research theme:

Computational-Chemistry-Guided Chemical Synthesis of FluorinatedAmino Acids

Person in charge:

Tsuyoshi MITA

Duration of research: 2021
Budget distribution:

3,000,000 yen

13) The Fugaku Trust for Medical Research
Research theme:

Synthesis of Fluorinated N-Heterocycles towards the Development ofPharmaceutical Substances

Person in charge:

Tsuyoshi MITA

Duration of research: 2021
Budget distribution:

2,000,000 yen

14) The Uehara Memorial Foundation
Research theme:

Chemical Synthesis of Pharmaceutical Ingredients by Quantum Chemical
Calculations

Person in charge:

Tsuyoshi MITA

Duration of research: 2020
Budget distribution:

5,000,000 yen

15) The Akiyama Life Science Foundation
20/22

Research theme:

Chemical Synthesis of Fluorinated Amino Acids Guided by Quantum
Chemical Calculations

Person in charge:

Tsuyoshi MITA

Duration of research: 2020
Budget distribution:

1,000,000 yen

16) Young Researcher's Award in the Ube Industries Foundation
Research theme:

Development of Novel Chemical Reactions Based on Quantum Chemical
Calculations

Person in charge:

Tsuyoshi MITA

Duration of research: 2020
Budget distribution:

1,000,000 yen17) Astellas Foundation for Research on Metabolic Disorders
Research theme:

Synthesis of Pharmaceutical Resources Based on Calculation

Person in charge:

Tsuyoshi MITA

Duration of research: 2019
Budget distribution:

2,000,000 yen18) The Sumitomo Foundation
Research theme:

Instant Carboxylation with CO2 for the Synthesis of PET Tracers

Person in charge:

Tsuyoshi MITA

Duration of research: 2018
Budget distribution:

1,100,000 yen

19) The Takeda Science Foundation
Research theme:

Carboxylation Triggered by the Cleavage of Heteroaromatics

Person in charge:

Tsuyoshi MITA

Duration of research: 2018
Budget distribution:

2,000,000 yen20) The Naito Foundation
Research theme:

Development of Novel C(sp3)-H Activation Reactions and their
Applications

Person in charge:

Tsuyoshi MITA

Duration of research: 2017
Budget distribution:

3,000,000 yen21) Grant-in-Aid for Regional R&D Proposal-Based Program from Northern Advancement Center for
Science & Technology of Hokkaido
Research theme:

Synthesis of Biological Active Molecules via C(sp3)-H Activation

Person in charge:

Tsuyoshi MITA

Duration of research: 2016
Budget distribution:

400,000 yen

22) The Uehara Memorial Foundation
Research theme:

Amino Acid Synthesis via C-H Activation
21/22

Person in charge:

Tsuyoshi MITA

Duration of research: 2010
Budget distribution:

2,000,000 yen

23) Corporation Award in Synthetic Organic Chemistry, Japan
Research theme:

Amino Acid Synthesis from Carbon Dioxide

Person in charge:

Tsuyoshi MITA

Duration of research: 2009
Budget distribution:

500,000 yen

22/22