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(1) Delaunay A, Pflieger D, Barrault MB, Vinh J, Toledano MB. (2002) Cell 15;111(4):471-81.
(2) Okazaki S, Tachibana T, Naganuma A, Mano N, Kuge S. (2007) Mol. Cell 27, 675-88.
(3) Okazaki S, Naganuma A and Kuge S, (2005) Antioxid. Redox. Signal. 7, 327-334.
(4) Tachibana T, Okazaki S, Murayama A, Naganuma A, Nomoto A and Kuge S. (2009) J Biol Chem.
13;284(7):4464-72. Epub 2008 Dec 22.

!$"& Ecl1 ( ' # % Ù}iÇ_»ÁÝXÎâ§ÆÐ5D/6D/=0àRy¸Ô\,v(ÙYÑâ§#À,Vx)}i[lwxn^KáÕ) 1)â§}iYÑ}iôXÎkõÄ}iôëYÑ¯´xèõ 'És¦zÄ}i(´x±,Ä¸ªz(Ôì(lwÔ,Ý"(YÑâ§,¶ ß¿YÑâ§u4?Jò·²(s¦z´x±,L(àRw­,c­,ò·²(SDpoíÏ´x±L×"&)ôemb¬õg£^EMMpo#(â§,¨¾pð#×"&)Z
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allw(,&(extender of chronological lifespan)ih 2)
 Ecl1 ¢ÛîTlwYÑâ§OXÎâ§K(,ÒX)&é#Ecl1 g£Ä}iç^(,¼× 3,4))& Ecl1 @-AEJâ§Ä}i[é+(Ólw(È²nÄ}içYwC1;8Bé(Ô,Ý"(KÍ1HEJ[êôïñ[êõ}iç^po3F4J7«,Ú 2óÅ(º&)(& 0.5ó[êYÑâ§,pðÄ}i,ªzYÑâ§#3F4J7æ,[ê(ç´(+¥3F4J7[êQM Ecl1 ,ò·²*3F4J7[ê`°rfÄ}ig Ecl1ò·²#1HEJ[ê,g£´³t_,´(dÌÈ&)

PEcl1 @-AEJ,ò·²(ßã_¨Â7:G7|,½!pðÄßSL(ÃËW©ãÂÀæ,UG7ÊuV#&1HEJ[ê$ã_7:´®À}i[{éÜ(§,¶ Ecl1 @-AEJÔ&}i[¤¢é(Þ¸q¹¸ºÒ(PEcl1 @-AEJâ§,ç´x(äÛ®Ø´µYå©¶½j)(#&YÑâ&)(&Ì],â§%(·â#¡(1) Roux, A.E., Quissac, A., Chartrand, P., Ferbeyre, G., and Rokeach, L.A. Regulation of chronological aging
in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell, 5, 345-357 (2006)
2) Ohtsuka, H., Mita, S., Ogawa, Y., Azuma, K., Ito, H., and Aiba, H. A novel gene, ecl1+, extends
chronological lifespan in fission yeast. FEMS Yeast Research 8, 520-530 (2008)
3) Ohtsuka, H., Ogawa, Y., Mizuno H., Mita, S., and Aiba, H. Identification of Ecl family genes that extend
chronological lifespan in fission yeast. Biosci. Biotech. Biochem. 73, 885-889 (2009)4) Azuma, K., Ohtsuka, H., Mita, S., Murakami, H., and Aiba, H. Identification and characterization of
Ecl1-family gene in Saccharomyces cerevisiae. Biosci. Biotech. Biochem. in press (2009)% . * % -&/,$+!  0"#(-&')kñ!f6g3L6CL5g=0č"Ĕ/#ÆÓĊòÃÓ~Ó É Hj\¢10'UO7ã!Ĕ/"ý+Ü /11ąõ×

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1ęTominaga T, et al. J. Agric. Food Chem. 1998, 46, 52151-5219.
2ęTominaga T, et al. J. Brew. Soc. Japan. 2003, 98, 628-637.
3ęKobayashi H, et al. J. ASEV. Jpn. 2006, 17, 75-80.
4ęKobayashi H, et al. J. ASEV. Jpn. 2007, 18, 22-27.
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