THROMBOSIS in EUDRA
By Craig Paardekooper

DATA SOURCE : Eudra Safety Signal Dataset (ESSD) : https://howbad.info/essd.zip

ESSD Online : https://knollfrank.github.io/HowBadIsMyBatch/SymptomsCausedByDrugs/

SAFETY SIGNALS GENERATED
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VAXZEVRIA
COMIRNATYTOZINAMERAN
MODERNASPIKEVAXELASOMERAN

17
7
3
1
0
0

Covid Vaccines :VAXZEVRIA – commonly referred to as “the clotshot”, had the highest number of safety signals forthrombosis.
It was withdrawn in Dec 2021 in the UK, and also inseveral other countries following safety issues.
COMIRNATY also had several safety signals forthrombosis, but was not withdrawn.

ORGANS EFFECTED•••VAXZEVRIA
COMIRNATYTOZINAMERAN

cerebral, sinus, mesenteric thrombi
ophthalmic, limb thrombi
pulmonary, cerebral thrombi

KEY
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LCL = lower confidence limit of PRR
PRR = proportional reporting ratio
LCL > 2 = Safety Signal

SYMPTOM = Ophthalmic vein thrombosis DRUG = COMIRNATYLCL = 5.1

SYMPTOM = Ophthalmic vein thrombosis DRUG = CYMBALTALCL = 3.82

SYMPTOM = Ophthalmic vein thrombosis DRUG = ELIQUISLCL = 3.16_______________________SYMPTOM = Vaccination site thrombosis DRUG = COMIRNATYLCL = 4.17_______________________SYMPTOM = Venous thrombosis limb DRUG = NOVOSEVENLCL = 26.48

SYMPTOM = Venous thrombosis limb DRUG = THALIDOMIDELCL = 11.01

SYMPTOM = Venous thrombosis limb DRUG = EVISTALCL = 10.72

SYMPTOM = Venous thrombosis limb DRUG = RINVOQLCL = 7.45

SYMPTOM = Venous thrombosis limb DRUG = AVASTIN

LCL = 6.48

SYMPTOM = Venous thrombosis limb DRUG = ASPARAGINASELCL = 3.61

SYMPTOM = Venous thrombosis limb DRUG = COMIRNATYLCL = 3.1_______________________SYMPTOM = Basilar artery thrombosis DRUG = COMIRNATYLCL = 2.76_______________________SYMPTOM = Superficial vein thrombosis DRUG = ATOSIBANLCL = 41.86

SYMPTOM = Superficial vein thrombosis DRUG = PROTELOSLCL = 19.1

SYMPTOM = Superficial vein thrombosis DRUG = EVISTALCL = 12.32

SYMPTOM = Superficial vein thrombosis DRUG = CELECOXIBLCL = 11.25

SYMPTOM = Superficial vein thrombosis DRUG = ACTRAPIDLCL = 9.91

SYMPTOM = Superficial vein thrombosis DRUG = VAXZEVRIALCL = 3.45

SYMPTOM = Superficial vein thrombosis DRUG = COMIRNATYLCL = 2.66

SYMPTOM = Superficial vein thrombosis DRUG = RINVOQLCL = 2.42

SYMPTOM = Superficial vein thrombosis DRUG = MODERNALCL = 2.34

SYMPTOM = Superficial vein thrombosis DRUG = APIXABANLCL = 2.3_______________________SYMPTOM = Ophthalmic artery thrombosis DRUG = COMIRNATYLCL = 2.09_______________________SYMPTOM = Ophthalmic vascular thrombosis DRUG = COMIRNATYLCL = 2.09_______________________SYMPTOM = Cerebral venous sinus thrombosis DRUG = ONCASPAR

LCL = 24.66

SYMPTOM = Cerebral venous sinus thrombosis DRUG = ASPARAGINASELCL = 13.8

SYMPTOM = Cerebral venous sinus thrombosis DRUG = NOVOSEVENLCL = 11.3

SYMPTOM = Cerebral venous sinus thrombosis DRUG = VAXZEVRIALCL = 6.95

SYMPTOM = Cerebral venous sinus thrombosis DRUG = APIXABANLCL = 2.41

SYMPTOM = Cerebral venous sinus thrombosis DRUG = HUMIRALCL = 2.33_______________________SYMPTOM = Portosplenomesenteric venous thrombosis DRUG = VAXZEVRIA_______________________

LCL = 4.7

SYMPTOM = Retinal vascular thrombosis DRUG = EVISTALCL = 47.76

SYMPTOM = Retinal vascular thrombosis DRUG = PEGINTRONLCL = 5.73

SYMPTOM = Retinal vascular thrombosis DRUG = PEGASYSLCL = 2.41_______________________SYMPTOM = Venous thrombosis DRUG = REGORAFENIBLCL = 30.67

SYMPTOM = Venous thrombosis DRUG = NOVOSEVENLCL = 28.67

SYMPTOM = Venous thrombosis DRUG = ASPARAGINASELCL = 17.49

SYMPTOM = Venous thrombosis DRUG = EVISTALCL = 13.77

SYMPTOM = Venous thrombosis DRUG = AVASTIN

LCL = 10.21

SYMPTOM = Venous thrombosis DRUG = ENOXAPARIN

LCL = 6.83

SYMPTOM = Venous thrombosis DRUG = CYTARABINELCL = 5.63

SYMPTOM = Venous thrombosis DRUG = NPLATELCL = 3.39

SYMPTOM = Venous thrombosis DRUG = RINVOQLCL = 2.98

SYMPTOM = Venous thrombosis DRUG = ELIQUISLCL = 2.65_______________________SYMPTOM = Retinal vein thrombosis DRUG = EVISTALCL = 110.85

SYMPTOM = Retinal vein thrombosis DRUG = VIAGRALCL = 11.93

SYMPTOM = Retinal vein thrombosis DRUG = PEGINTRONLCL = 9.98

SYMPTOM = Retinal vein thrombosis DRUG = PEGASYSLCL = 3.85

SYMPTOM = Retinal vein thrombosis DRUG = NEXAVARLCL = 3.38_______________________SYMPTOM = Cerebral venous thrombosis DRUG = ASPARAGINASELCL = 68.82

SYMPTOM = Cerebral venous thrombosis DRUG = ONCASPAR

LCL = 33.37

SYMPTOM = Cerebral venous thrombosis DRUG = ENOXAPARIN

LCL = 10.76

SYMPTOM = Cerebral venous thrombosis DRUG = CYTARABINELCL = 3.74

SYMPTOM = Cerebral venous thrombosis DRUG = VAXZEVRIALCL = 2.77______________________________________________SYMPTOM = Subclavian vein thrombosis DRUG = NOVOSEVENLCL = 109.27

SYMPTOM = Subclavian vein thrombosis DRUG = DOCETAXELLCL = 36.32_______________________

_______________________SYMPTOM = Pelvic venous thrombosis DRUG = NOVOSEVENLCL = 96.66

SYMPTOM = Pelvic venous thrombosis DRUG = ELIQUISLCL = 2.24_______________________SYMPTOM = Cerebral thrombosis DRUG = NOVOSEVENLCL = 21.58

SYMPTOM = Cerebral thrombosis DRUG = ONCASPAR

LCL = 21.49

SYMPTOM = Cerebral thrombosis DRUG = ASPARAGINASELCL = 10.17

SYMPTOM = Cerebral thrombosis DRUG = XARELTOLCL = 8.36

SYMPTOM = Cerebral thrombosis DRUG = APIXABANLCL = 3.51

SYMPTOM = Cerebral thrombosis DRUG = ELIQUISLCL = 3.25

SYMPTOM = Cerebral thrombosis DRUG = SOLIRISLCL = 2.85

SYMPTOM = Cerebral thrombosis DRUG = TOZINAMERANLCL = 2.53

SYMPTOM = Cerebral thrombosis DRUG = VAXZEVRIALCL = 2.04_______________________SYMPTOM = Transverse sinus thrombosis DRUG = ASPARAGINASELCL = 29.5

SYMPTOM = Transverse sinus thrombosis DRUG = VAXZEVRIALCL = 3.79_______________________SYMPTOM = Mesenteric vein thrombosis DRUG = TESTOSTERONELCL = 49.82

SYMPTOM = Mesenteric vein thrombosis DRUG = NOVOSEVENLCL = 48.53

SYMPTOM = Mesenteric vein thrombosis DRUG = ADENURICLCL = 46.55

SYMPTOM = Mesenteric vein thrombosis DRUG = NEXAVARLCL = 2.9

SYMPTOM = Mesenteric vein thrombosis DRUG = VAXZEVRIALCL = 2.15_______________________SYMPTOM = Deep vein thrombosis DRUG = EVISTALCL = 32.63

SYMPTOM = Deep vein thrombosis DRUG = NOVOSEVENLCL = 20.65

SYMPTOM = Deep vein thrombosis DRUG = PROTELOSLCL = 18.98

SYMPTOM = Deep vein thrombosis DRUG = TESTOSTERONELCL = 15.42

SYMPTOM = Deep vein thrombosis DRUG = THALIDOMIDELCL = 12.46

SYMPTOM = Deep vein thrombosis DRUG = DABIGATRANLCL = 8.23

SYMPTOM = Deep vein thrombosis DRUG = ANAKINRALCL = 7.39

SYMPTOM = Deep vein thrombosis DRUG = XARELTOLCL = 7.12

SYMPTOM = Deep vein thrombosis DRUG = EVRALCL = 7.04

SYMPTOM = Deep vein thrombosis DRUG = NPLATELCL = 6.67

SYMPTOM = Deep vein thrombosis DRUG = ELIQUISLCL = 6.09

SYMPTOM = Deep vein thrombosis DRUG = ENOXAPARIN

LCL = 5.71

SYMPTOM = Deep vein thrombosis DRUG = INHIXALCL = 5.57

SYMPTOM = Deep vein thrombosis DRUG = TOFACITINIBLCL = 5.06

SYMPTOM = Deep vein thrombosis DRUG = RINVOQLCL = 4.62

SYMPTOM = Deep vein thrombosis DRUG = RIVAROXABANLCL = 4.32

SYMPTOM = Deep vein thrombosis DRUG = CANAGLIFLOZINLCL = 3.87

SYMPTOM = Deep vein thrombosis DRUG = AVASTIN

LCL = 3.44

SYMPTOM = Deep vein thrombosis DRUG = EBIXALCL = 3.41

SYMPTOM = Deep vein thrombosis DRUG = EVUSHELDLCL = 3.16

SYMPTOM = Deep vein thrombosis DRUG = OSIMERTINIBLCL = 3.06

SYMPTOM = Deep vein thrombosis DRUG = UPADACITINIBLCL = 3.0

SYMPTOM = Deep vein thrombosis DRUG = REVLIMID

LCL = 2.9

SYMPTOM = Deep vein thrombosis DRUG = RAPAMUNELCL = 2.81

SYMPTOM = Deep vein thrombosis DRUG = ARIXTRALCL = 2.79

SYMPTOM = Deep vein thrombosis DRUG = ESMYALCL = 2.78

SYMPTOM = Deep vein thrombosis DRUG = EPOETINLCL = 2.58

SYMPTOM = Deep vein thrombosis DRUG = BEVACIZUMABLCL = 2.54

SYMPTOM = Deep vein thrombosis DRUG = KYPROLISLCL = 2.51

SYMPTOM = Deep vein thrombosis DRUG = HUMANLCL = 2.49

SYMPTOM = Deep vein thrombosis DRUG = CARFILZOMIBLCL = 2.2

SYMPTOM = Deep vein thrombosis DRUG = VELCADELCL = 2.2

SYMPTOM = Deep vein thrombosis DRUG = TAGRISSOLCL = 2.19

SYMPTOM = Deep vein thrombosis DRUG = DEXAMETHASONE

LCL = 2.06

SYMPTOM = Deep vein thrombosis DRUG = DARATUMUMABLCL = 2.04

SYMPTOM = Deep vein thrombosis DRUG = ZOMETALCL = 2.0______________________________________________SYMPTOM = Vertebral artery thrombosis DRUG = VAXZEVRIALCL = 2.2

_______________________SYMPTOM = Ovarian vein thrombosis DRUG = ELIQUISLCL = 26.51_______________________SYMPTOM = Thrombosis with thrombocytopenia syndrome DRUG = VAXZEVRIA LCL = 32.32_______________________SYMPTOM = Peripheral artery thrombosis DRUG = NOVOSEVENLCL = 137.68

SYMPTOM = Peripheral artery thrombosis DRUG = AERIUS

LCL = 17.71

SYMPTOM = Peripheral artery thrombosis DRUG = ICLUSIGLCL = 11.32

SYMPTOM = Peripheral artery thrombosis DRUG = TASIGNALCL = 10.04

SYMPTOM = Peripheral artery thrombosis DRUG = FASLODEXLCL = 6.62

SYMPTOM = Peripheral artery thrombosis DRUG = ELIQUISLCL = 3.65

SYMPTOM = Peripheral artery thrombosis DRUG = CLOPIDOGRELLCL = 2.86_______________________SYMPTOM = Thrombosis DRUG = ANGIOXLCL = 15.07

SYMPTOM = Thrombosis DRUG = NOVOSEVENLCL = 12.16

SYMPTOM = Thrombosis DRUG = INTEGRILIN

LCL = 10.43

SYMPTOM = Thrombosis DRUG = ELIQUISLCL = 9.99

SYMPTOM = Thrombosis DRUG = EVISTALCL = 6.85

SYMPTOM = Thrombosis DRUG = RUCONESTLCL = 6.54

SYMPTOM = Thrombosis DRUG = MISOPROSTOLLCL = 6.28

SYMPTOM = Thrombosis DRUG = RIVAROXABANLCL = 5.26

SYMPTOM = Thrombosis DRUG = REVLIMID

LCL = 5.23

SYMPTOM = Thrombosis DRUG = NPLATELCL = 4.13

SYMPTOM = Thrombosis DRUG = ANAKINRALCL = 4.03

SYMPTOM = Thrombosis DRUG = XARELTOLCL = 3.62

SYMPTOM = Thrombosis DRUG = RINVOQLCL = 3.35

SYMPTOM = Thrombosis DRUG = EVRALCL = 3.13

SYMPTOM = Thrombosis DRUG = ENOXAPARIN

LCL = 3.04

SYMPTOM = Thrombosis DRUG = IBRANCELCL = 2.92

SYMPTOM = Thrombosis DRUG = XELJANZ

LCL = 2.91

SYMPTOM = Thrombosis DRUG = TESTOSTERONELCL = 2.9

SYMPTOM = Thrombosis DRUG = PLAVIXLCL = 2.87

SYMPTOM = Thrombosis DRUG = HIZENTRALCL = 2.85

SYMPTOM = Thrombosis DRUG = XALKORILCL = 2.79

SYMPTOM = Thrombosis DRUG = TOZINAMERANLCL = 2.64

SYMPTOM = Thrombosis DRUG = CINRYZELCL = 2.48

SYMPTOM = Thrombosis DRUG = VELTASSALCL = 2.34

SYMPTOM = Thrombosis DRUG = SOLIRISLCL = 2.2

SYMPTOM = Thrombosis DRUG = LIXIANALCL = 2.19

SYMPTOM = Thrombosis DRUG = INLYTA

LCL = 2.14

SYMPTOM = Thrombosis DRUG = NINLAROLCL = 2.09

SYMPTOM = Thrombosis DRUG = BYDUREONLCL = 2.02_______________________SYMPTOM = Visceral venous thrombosis DRUG = VAXZEVRIALCL = 8.82______________________________________________SYMPTOM = Retinal artery thrombosis DRUG = VIAGRALCL = 19.1

SYMPTOM = Retinal artery thrombosis DRUG = PEGINTRONLCL = 16.19

SYMPTOM = Retinal artery thrombosis DRUG = PEGASYSLCL = 4.08_______________________SYMPTOM = Cerebral artery thrombosis DRUG = ESOMEPRAZOLELCL = 139.13

SYMPTOM = Cerebral artery thrombosis DRUG = NOVOSEVENLCL = 76.91

SYMPTOM = Cerebral artery thrombosis DRUG = CELECOXIBLCL = 40.88_______________________SYMPTOM = Jugular vein thrombosis DRUG = NOVOSEVENLCL = 71.45

SYMPTOM = Jugular vein thrombosis DRUG = GONALF

LCL = 70.3

SYMPTOM = Jugular vein thrombosis DRUG = ONCASPAR

LCL = 38.61

SYMPTOM = Jugular vein thrombosis DRUG = AVASTIN

LCL = 9.69

SYMPTOM = Jugular vein thrombosis DRUG = AFINITORLCL = 3.08_______________________SYMPTOM = Portal vein thrombosis DRUG = NOVOSEVENLCL = 34.19

SYMPTOM = Portal vein thrombosis DRUG = TESTOSTERONELCL = 22.91

SYMPTOM = Portal vein thrombosis DRUG = EXVIERALCL = 18.78

SYMPTOM = Portal vein thrombosis DRUG = LENVIMALCL = 16.96

SYMPTOM = Portal vein thrombosis DRUG = OLYSIOLCL = 16.43

SYMPTOM = Portal vein thrombosis DRUG = SOVALDI

LCL = 15.42

SYMPTOM = Portal vein thrombosis DRUG = RIBAVIRINLCL = 11.54

SYMPTOM = Portal vein thrombosis DRUG = NEXAVARLCL = 10.14

SYMPTOM = Portal vein thrombosis DRUG = HARVONILCL = 9.43

SYMPTOM = Portal vein thrombosis DRUG = NPLATELCL = 9.27

SYMPTOM = Portal vein thrombosis DRUG = BEVACIZUMABLCL = 8.67

SYMPTOM = Portal vein thrombosis DRUG = AVASTIN

LCL = 7.56

SYMPTOM = Portal vein thrombosis DRUG = JAKAVILCL = 7.4

SYMPTOM = Portal vein thrombosis DRUG = ESOMEPRAZOLELCL = 6.2

SYMPTOM = Portal vein thrombosis DRUG = SOLIRISLCL = 5.93

SYMPTOM = Portal vein thrombosis DRUG = CABOMETYXLCL = 4.84

SYMPTOM = Portal vein thrombosis DRUG = RINVOQLCL = 4.48

SYMPTOM = Portal vein thrombosis DRUG = INCIVO

LCL = 3.66

SYMPTOM = Portal vein thrombosis DRUG = VAXZEVRIALCL = 2.19

SYMPTOM = Portal vein thrombosis DRUG = JANUVIALCL = 2.16

SYMPTOM = Portal vein thrombosis DRUG = PEGINTRONLCL = 2.11______________________________________________SYMPTOM = Arterial thrombosis DRUG = NOVOSEVENLCL = 55.74

SYMPTOM = Arterial thrombosis DRUG = CRIXIVANLCL = 28.06

SYMPTOM = Arterial thrombosis DRUG = ELIQUISLCL = 5.64

SYMPTOM = Arterial thrombosis DRUG = TASIGNALCL = 5.01

SYMPTOM = Arterial thrombosis DRUG = CLOPIDOGRELLCL = 3.0_______________________SYMPTOM = Pulmonary artery thrombosis DRUG = BEVACIZUMABLCL = 26.96

SYMPTOM = Pulmonary artery thrombosis DRUG = AVASTIN

LCL = 22.27_______________________SYMPTOM = Coronary artery thrombosis DRUG = ANGIOXLCL = 731.24

SYMPTOM = Coronary artery thrombosis DRUG = INTEGRILIN

LCL = 179.42

SYMPTOM = Coronary artery thrombosis DRUG = ZYLLTLCL = 160.66

SYMPTOM = Coronary artery thrombosis DRUG = CLOPIDOGRELLCL = 17.22

SYMPTOM = Coronary artery thrombosis DRUG = PLAVIXLCL = 13.13

SYMPTOM = Coronary artery thrombosis DRUG = BRILIQUELCL = 10.92

SYMPTOM = Coronary artery thrombosis DRUG = AVANDIA

LCL = 4.82_______________________SYMPTOM = Aortic thrombosis DRUG = NOVOSEVENLCL = 74.4

SYMPTOM = Aortic thrombosis DRUG = CLOPIDOGRELLCL = 6.21

SYMPTOM = Aortic thrombosis DRUG = ELIQUISLCL = 3.1_______________________SYMPTOM = Cardiac ventricular thrombosis DRUG = NOVOSEVENLCL = 41.58

SYMPTOM = Cardiac ventricular thrombosis DRUG = ASPARAGINASELCL = 33.34

SYMPTOM = Cardiac ventricular thrombosis DRUG = ELIQUISLCL = 13.48

SYMPTOM = Cardiac ventricular thrombosis DRUG = AVANDIA

LCL = 11.48

SYMPTOM = Cardiac ventricular thrombosis DRUG = AVANDAMETLCL = 11.34

SYMPTOM = Cardiac ventricular thrombosis DRUG = CLOPIDOGRELLCL = 6.59

SYMPTOM = Cardiac ventricular thrombosis DRUG = BRILIQUELCL = 4.67

SYMPTOM = Cardiac ventricular thrombosis DRUG = ENTRESTO

LCL = 2.87

SYMPTOM = Cardiac ventricular thrombosis DRUG = PLAVIXLCL = 2.29_______________________SYMPTOM = Renal vein thrombosis DRUG = SUTENTLCL = 3.41______________________________________________SYMPTOM = Carotid artery thrombosis DRUG = ALISKIRENLCL = 1760.1_______________________SYMPTOM = Superior sagittal sinus thrombosis DRUG = ONCASPAR

LCL = 175.08

SYMPTOM = Superior sagittal sinus thrombosis DRUG = ASPARAGINASELCL = 110.18

SYMPTOM = Superior sagittal sinus thrombosis DRUG = VAXZEVRIALCL = 3.28_______________________SYMPTOM = Pulmonary thrombosis DRUG = ANAKINRALCL = 55.85

SYMPTOM = Pulmonary thrombosis DRUG = MISOPROSTOLLCL = 50.67

SYMPTOM = Pulmonary thrombosis DRUG = PEGFILGRASTIMLCL = 17.39

SYMPTOM = Pulmonary thrombosis DRUG = IBRANCELCL = 8.38

SYMPTOM = Pulmonary thrombosis DRUG = ELIQUISLCL = 7.27

SYMPTOM = Pulmonary thrombosis DRUG = REVLIMID

LCL = 6.99

SYMPTOM = Pulmonary thrombosis DRUG = OMALIZUMABLCL = 6.22

SYMPTOM = Pulmonary thrombosis DRUG = XARELTOLCL = 5.56

SYMPTOM = Pulmonary thrombosis DRUG = REVATIOLCL = 4.93

SYMPTOM = Pulmonary thrombosis DRUG = XELJANZ

LCL = 4.89

SYMPTOM = Pulmonary thrombosis DRUG = XALKORILCL = 4.6

SYMPTOM = Pulmonary thrombosis DRUG = EVISTALCL = 4.56

SYMPTOM = Pulmonary thrombosis DRUG = ESBRIETLCL = 4.37

SYMPTOM = Pulmonary thrombosis DRUG = RINVOQLCL = 3.47

SYMPTOM = Pulmonary thrombosis DRUG = LYRICALCL = 3.14

SYMPTOM = Pulmonary thrombosis DRUG = OPSUMITLCL = 2.93

SYMPTOM = Pulmonary thrombosis DRUG = TOZINAMERANLCL = 2.92

SYMPTOM = Pulmonary thrombosis DRUG = VOTRIENTLCL = 2.41

SYMPTOM = Pulmonary thrombosis DRUG = TRELEGYLCL = 2.34

SYMPTOM = Pulmonary thrombosis DRUG = INLYTA

LCL = 2.26_______________________SYMPTOM = Splenic vein thrombosis DRUG = JANUMETLCL = 36.03

SYMPTOM = Splenic vein thrombosis DRUG = JANUVIALCL = 13.08

SYMPTOM = Splenic vein thrombosis DRUG = VAXZEVRIALCL = 2.56_______________________SYMPTOM = Vena cava thrombosis DRUG = NOVOSEVENLCL = 169.03

SYMPTOM = Vena cava thrombosis DRUG = AVASTIN

LCL = 13.81

SYMPTOM = Vena cava thrombosis DRUG = VOTRIENTLCL = 8.45

SYMPTOM = Vena cava thrombosis DRUG = SUTENTLCL = 6.37

SYMPTOM = Vena cava thrombosis DRUG = STELARA

LCL = 2.78

SYMPTOM = Vena cava thrombosis DRUG = ELIQUISLCL = 2.53_______________________

SYMPTOM = Atrial thrombosis DRUG = MISOPROSTOLLCL = 220.96

SYMPTOM = Atrial thrombosis DRUG = ELIQUISLCL = 74.39

SYMPTOM = Atrial thrombosis DRUG = NOVOSEVENLCL = 54.13

SYMPTOM = Atrial thrombosis DRUG = LIXIANALCL = 51.05

SYMPTOM = Atrial thrombosis DRUG = APIXABANLCL = 10.74

SYMPTOM = Atrial thrombosis DRUG = BUSULFANLCL = 7.88

SYMPTOM = Atrial thrombosis DRUG = CLOPIDOGRELLCL = 3.07_______________________SYMPTOM = Thrombosis in device DRUG = ANGIOXLCL = 1411.73

SYMPTOM = Thrombosis in device DRUG = INTEGRILIN

LCL = 57.22

SYMPTOM = Thrombosis in device DRUG = EFIENT

LCL = 54.4

SYMPTOM = Thrombosis in device DRUG = NOVOSEVENLCL = 36.72

SYMPTOM = Thrombosis in device DRUG = PLAVIXLCL = 35.79

SYMPTOM = Thrombosis in device DRUG = BRILIQUELCL = 25.47

SYMPTOM = Thrombosis in device DRUG = CLOPIDOGRELLCL = 19.26

SYMPTOM = Thrombosis in device DRUG = OPSUMITLCL = 6.66_______________________SYMPTOM = Vascular stent thrombosis DRUG = BRILIQUELCL = 158.33

SYMPTOM = Vascular stent thrombosis DRUG = ZYLLTLCL = 138.02

SYMPTOM = Vascular stent thrombosis DRUG = EFIENT

LCL = 98.72

SYMPTOM = Vascular stent thrombosis DRUG = ANGIOXLCL = 89.52

SYMPTOM = Vascular stent thrombosis DRUG = CLOPIDOGRELLCL = 49.45

SYMPTOM = Vascular stent thrombosis DRUG = PLAVIXLCL = 34.47

SYMPTOM = Vascular stent thrombosis DRUG = TICAGRELORLCL = 30.77

SYMPTOM = Vascular stent thrombosis DRUG = INTEGRILIN

LCL = 27.1_______________________SYMPTOM = Sigmoid sinus thrombosis DRUG = VAXZEVRIALCL = 5.73_______________________SYMPTOM = Hepatic vein thrombosis DRUG = SOLIRISLCL = 30.21

SYMPTOM = Hepatic vein thrombosis DRUG = VAXZEVRIALCL = 4.59_______________________

SYMPTOM = Splenic artery thrombosis DRUG = VAXZEVRIALCL = 3.83_______________________SYMPTOM = Cavernous sinus thrombosis DRUG = VAXZEVRIALCL = 2.17________________________________________________________________________________________________________________________________________________________________________________________SYMPTOM = Arteriovenous fistula thrombosis DRUG = ARANESPLCL = 31.46___________________________________________________________________________________________________________________SYMPTOM = Coronary bypass thrombosis DRUG = NOVOSEVENLCL = 1849.41_______________________SYMPTOM = Deep vein thrombosis postoperative DRUG = ADALIMUMABLCL = 100.99

SYMPTOM = Deep vein thrombosis postoperative DRUG = ABATACEPTLCL = 35.63

SYMPTOM = Deep vein thrombosis postoperative DRUG = APREPITANTLCL = 27.82

SYMPTOM = Deep vein thrombosis postoperative DRUG = ARAVALCL = 14.77

SYMPTOM = Deep vein thrombosis postoperative DRUG = MYCOPHENOLATE

LCL = 13.6

SYMPTOM = Deep vein thrombosis postoperative DRUG = APREMILASTLCL = 8.38

SYMPTOM = Deep vein thrombosis postoperative DRUG = AMINOSALICYLICLCL = 5.14

SYMPTOM = Deep vein thrombosis postoperative DRUG = COSENTYX

LCL = 2.43_______________________SYMPTOM = Device related thrombosis DRUG = ANGIOXLCL = 252.84

SYMPTOM = Device related thrombosis DRUG = NOVOSEVENLCL = 73.56

SYMPTOM = Device related thrombosis DRUG = AVASTIN

LCL = 19.4

SYMPTOM = Device related thrombosis DRUG = ELIQUISLCL = 3.2___________________________________________________________________________________________________________________SYMPTOM = Infusion site thrombosis DRUG = AZATHIOPRINELCL = 247.6_______________________SYMPTOM = Injection site thrombosis DRUG = nan

LCL = 5.54_______________________SYMPTOM = Intrapericardial thrombosis DRUG = NOVOSEVENLCL = 1585.3____________________________________________________________________________________________SYMPTOM = Postoperative thrombosis DRUG = ELIQUISLCL = 14.26_____________________________________________________________________SYMPTOM = Prosthetic cardiac valve thrombosis DRUG = ENOXAPARIN

LCL = 299.41

SYMPTOM = Prosthetic cardiac valve thrombosis DRUG = nan

LCL = 2.82_______________________________________________________________________________________________________________________________________________________________________________________________________________

_______________________SYMPTOM = Tumour thrombosis DRUG = NEXAVAR_________________________________________________________________________________________________________________________________________________________________

LCL = 148.06