Chemical Biology 部⾨・Review in Journal (雑誌総説)
1) Tomohiro. Tomohiro, Makoto Hashimoto, Yasumaru Hatanaka, Cross-Linking chemistry and biology:Development of multifunctional photoaffinity probes, Chem. Record, 5, 385-395 (2005).
2) Makoto Hashimoto, Yasumaru Hatanaka, Recent progress in diazirine-based photoaffinity labeling, Eur. J.
Org. Chem., 2513-2523 (2008)
3) Makoto Hashimoto, Yuta Murai, Synthesis of photoreactive aromatic α-amino acids and effective hydrogendeuterium exchange for aromatic α-amino acids, （光反応性芳⾹族 α−アミノ酸誘導体の合成と芳⾹族 α−アミノ酸を標的とした効率的⽔素—重⽔素交換反応), J. Syn. Org. Chem. Jpn.(有機合成化学協会誌), 72,360-369 (2014)
4) Lei Wang, Yuta Murai, Takuma Yoshida, Masashi Okamoto, Zetryana Puteri Tachrim, Yasuyuki Hashidoko,
Makoto Hashimoto, Utilization of acidic α-amino acids as acyl donors: an effective stereocontrollable synthesisof aryl-keto α-amino acids and their derivatives, Molecules, 19, 6349-6367 (2014);
doi:10.3390/molecules19056349.
5) Zetryana Puteri Tachrim, Lei Wang, Yuta Murai, Takuma Yoshida, Natsumi Kurokawa, Fumina Ohashi,Yasuyuki Hashidoko, Makoto Hashimoto, Triflouromethanesulfonic acid as acylation catalyst: Special featurefor C- and/or O-acylation reactions, Catalysts, 7, 40 (2017); doi:10.3390/catal7020040
・Review in Book(単⾏本総説)
1) Makoto Hashimoto, Yuta Murai, Geoffery D. Holman, Yasumaru Hatanaka, Selective hydrogenation andtransfer hydrogenation for post-functional synthesis of trifluoromethylphenyl diazirine derivatives forphotoaffinity labeling, Hydrogenation, Edited by Iyad Karamé, ISBN 978-953-51-0785-9, pp.121-136, Publisher:InTech (2012).
2) Makoto Hashimoto, Multifunctional photoprobes for identification of ligand sites within biomolecules, In:Yasumaru Hatanaka, Makoto Hashimoto (eds) Photoaffinity labeling for structural probing within protein.
Springer, Tokyo, pp. 1-11 (2017)3) Yuta Murai, Lei Wang, Makoto Hashimoto, (2017) Synthesis of diazirinyl photophore and optically purediazirinylphenylalanines for photoaffinity labeling. In: Yasumaru Hatanaka, Makoto Hashimoto (eds)
Photoaffinity labeling for structural probing within protein. Springer, Tokyo, pp. 111-128 (2017)4) Makoto Hashimoto, Diaziridines and diazirines, Three-membered heterocycles, and all fused systems with athree-membered heterocyclic ring, In: Comprehensive Heterocyclic Chemistry IV (Reference Module inChemistry, Molecular Sciences and Chemical Engineering), 1-16 (2019); https://doi.org/10.1016/B978-0-12409547-2.14763-8
Original article (selected)
1) Katsuyoshi Masuda, Ayako Koizumi, Takumi Misaka, Yasumaru Hatanaka, Keiko Abe, Takaharu Tanaka,
Masaji Ishiguro, Makoto Hashimoto, Photoactive ligands probing the sweet taste receptor. Design and synthesisof highly potent diazirinyl D-phenylalanine derivatives, Bioorg. Med. Chem. Lett., 20, 1081-1083 (2010).
2) Ryo Murashige, Yuka Hayashi, Syo Ohmori, Ayuko Torii, Yoko Aizu, Yasuyuki Muto, Yuta Murai, Yuji Oda,
Makoto Hashimoto, Comparisons of O-acylation and Friedel-Crafts acylation of phenols and acyl chlorides andFries rearrangement of phenyl esters in triﬂuoromethanesulfonic acid: Effective synthesis of optically active

homotyrosines, Tetrahedron, 67, 641-649 (2011); https://doi.org/10.1016/j.tet.2010.11.047
3) Yuta Murai, Katsuyoshi Masuda, Yasuko Sakihama, Yasuyuki Hashidoko, Yasumaru Hatanaka, Makoto
Hashimoto, Comprehensive synthesis of photoreactive (3-trifluoromethyl)diazirinyl indole derivatives from 5and 6- trifluoroacetylindoles for photoaffinity labeling, J. Org. Chem., 77, 8581-8587 (2012).
dx.doi.org/10.1021/jo301552m
4) Yuta Murai, Lei Wang, Katsuyoshi Masuda, Yasuko Sakihama, Yasuyuki Hashidoko, Yasumaru Hatanaka,
Makoto Hashimoto, Rapid and controllable hydrogen-deuterium exchange on aromatic rings of α-amino acids
and peptides, Eur. J. Org. Chem., 5111–5116 (2013).
5) Lei Wang, Yuta Murai, Takuma Yoshida, Masashi Okamoto, Katsuyoshi Masuda, Yasuko Sakihama, Yasuyuki
Hashidoko, Yasumaru Hatanaka, Makoto Hashimoto, Hydrogen-deuterium exchange of cross-linkable α-aminoacid derivatives in deuterated triflic acid, Biosci. Biotechnol. Biochem., 78, 1129-1134 (2014).
6) Lei Wang, Yuta Murai, Takuma Yoshida, Akiko Ishida, Katsuyoshi Masuda, Yasuko Sakihama, Yasuyuki
Hashidoko,
Yasumaru
Hatanaka,
MakotoHashimoto,
Alternative
one-potsynthesisof(trifluoromethyl)phenyldiazirines from tosyloxime derivatives: Application for new synthesis of optically purediazirinylphenylalanines for photoaffinity labeling, Org. Lett., 17, 616-619 (2015). DOI: 10.1021/ol503630z
7) Lei Wang, Takuma Yoshida, Yasuyuki Muto, Yuta Murai, Zetryana Puteri Tachrim, Akiko Ishida, Shiori
Nakagawa, Yasuko Sakihama, Yasuyuki Hashidoko, Katsuyoshi Masuda, Yasumaru Hatanaka, Makoto
Hashimoto, Synthesis of Diazirine Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling ofGustatory Receptors., Eur. J. Org. Chem., 3129–3134 (2015)8) Zetryana Puteri Tachrim, Lei Wang, Takuma Yoshida, Miho Muto, Tadashi Nakamura, Katsuyoshi Masuda,Yasuyuki Hashidoko, Makoto Hashimoto, Comprehensive structural analysis of halogenated sucrose derivatives:
Revisiting the reactivity of sucrose primary alcohols, ChemistrySelect, 1, 58-62 (2016); DOI:
10.1002/slct.201500003
9) Lei Wang, Yasuyuki Hashidoko, Makoto Hashimoto, Co-solvent promoted O-benzylation with silver(I) oxide:
Synthesis of 1'-benzylated sucrose derivatives, mechanistic studies and scope investigation, J. Org. Chem., 81,4464–4474 (2016); DOI: 10.1021/acs.joc.6b00144
10) Lei Wang, Akiko Ishida, Yasuyuki Hashidoko, Makoto Hashimoto, Dehydrogenation of NH-NH bondtriggered by potassium t-butoxide in liquid NH3, Angew. Chem. Int. Ed., 56, 870-873 (2017), DOI:
10.1002/anie.201610371
11) Akiko Ishida, Lei Wang, Zetryana Puteri Tachrim, Takeyuki Suzuki, Yasuko Sakihama, Yasuyuki Hashidoko,
Makoto Hashimoto, Comprehensive synthesis of photoreactive phenylthiourea derivatives for the photoaffinity
labeling, ChemistrySelect, 2, 160-164 (2017); DOI: 10.1002/slct.201601675
12) Shiori Nakagawa, Zetryana Puteri Tachrim, Natsumi Kurokawa, Fumina Ohashi, Yasuko Sakihama, TakeyukiSuzuki, Yasuyuki Hashidoko, Makoto Hashimoto, pH Stability and antioxidant power of cyclodopa and its
derivatives, Molecules, 23, 1943 (2018); https://doi.org/10.3390/molecules23081943
13) Zetryana Puteri Tachrim, Shiori Nakagawa, Tadashi Nakamura, Fumina Ohashi, Natsumi Kurokawa, HarunaWakasa, Yurika Tokoro, Yasuko Sakihama, Yasuyuki Hashidoko, Takeyuki Suzuki, Makoto Hashimoto,
Synthesis of deuterated cyclodopa with hydrogen/deuterium exchange, Heterocycles, 99, 404-414 (2019); DOI:
10.3987/COM-18-S(F)33
14) Zetryana Puteri Tachrim, Natsumi Kurokawa, Yurika Tokoro, Makoto Hashimoto, Hydrogen-deuterium
exchange of histidine and histamine with deuterated trifluoromethanesulfonic acid, Heterocycles, 101, 357-362(2020); DOI: 10.3987/COM-19-S(F)28

15) Tomoya Nakagita, Akiko Ishida, Zetryana Puteri Tachrim, Lei Wang, Takumi Misaka, Makoto Hashimoto,
Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors,Molecules, 25, 2790 (2020); doi:10.3390/molecules25122790

Plant Response 部門・Chapter in Book
1) Y. Sakihama, Hideo Yamasaki
Phytochemical Antioxidants: Past, Present and Future In Antioxidants. Ed. Viduranga Yashasvi Waisundara,
IntechOpen, (2021). DOI: 10.5772/intechopen.95627
2) 崎浜靖子 「植物色素ベタレイン―分布，生合成および生理機能~謎に包まれた多機能性植物色素~」化
学と生物・今日の話題 55. 582-584 (2017).
3) H. Yamasaki, N.S. Watanabe, Y. Sakihama, M.F. Cohen. An overview of methods in plant NO research: Whydo we always need to use multiple methods? In: Methods in Molecular Biology: Plant Nitric Oxide: Methods& Protocol (K.J. Gupta ed.), Humana Press. Totowa, NJ. 1424:1-14 (2015).

・Original article (selected)
1) D.A. Suroto, S. Kitani, K.T. Miyamoto, Y. Sakihama, M. Arai, H. Ikeda, and T. Nihira. Activation of cryptic
phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue
AvaR3. Journal of Bioscience Bioengineering, (2017), http://dx.doi.org/10.1016/j.jbiosc. 2017.06.014.
2) Y. Yamashita, M. Ota, Y. Inoue, Y. Hasebe, M. Okamoto, T. Inukai, C. Masuta, Y. Sakihama, Y. Hashidoko,
M. Kojima, H. Sakakibara, Y. Inage, K. Takahashi, T. Yoshihara and H. Matsuura. Chemical Promotion ofEndogenous Amounts of ABA in Arabidopsis thaliana by a Natural Product, Theobroxide. Plant and Cell
Physiology, 57, 986-999 (2016).
3) S. Prama Putri, K. Ishido, H. Kinoshita, S. Kitani, F. Ihara, Y. Sakihama. Y. Igarashi, and T. Nihira, Productionof antioomycete compounds active against the phytopathogens Phytophthora sojae and Aphanomyces cochlioides
by clavicipitoid entomopathogenic fungi. J. Biosci. Bioengin., 117, 557-562 (2014).
4) Y. Sakihama*, M. Maeda, M. Hashimoto, S. Tahara, Y. Hashidoko. Beetroot betalain inhibits peroxynitritemediated tyrosine nitration and DNA strand cleavage, Free Radical Research, 46, 93–99 (2012).
5) Md.T.Islam, M.Sakasai, Y.Hashidoko, A.Deora, Y.Sakihama, S.Tahara, Composition of culture medium
influences zoosporogenesis and differentiation of Aphanomyces cochlioides. Journal of General Plant
Pathology, 73, 324-329 (2007).
6) B. M. Tyler et al. (containing Y. Sakihama). Phytophthora genome sequences uncover evolutionary origins
and mechanisms of pathogenesis, Science, 313, 1261-1266 (2006).
7) M.S. Connolly, Y. Sakihama, V. Phuntumart, Y. Jiang, F. Warren, L. Mourant and P.F. Morris, Heterologous
expression of a pleiotropic drug resistance transporter from Phytophthora sojae in yeast transporter mutants.
Current Genetics 48, 356-365 (2005).

8) Y. Sakihama, T. Shimai, M. Sakasai, T. Ito, Y. Fukushi, Y. Hashidoko and S. Tahara. A photoaffinity probe
designed for host-specific signal flavonoid receptors in phytopathogenic Peronosporomycete zoospores ofAphanomyces cochlioides. Archives of Biochemistry and Biophysics 432, 145-151 (2004).
9) Y. Sakihama, R. Tamaki, H. Shimoji, T. Ichiba, Y. Fukushi, S. Tahara, and H. Yamasaki. Enzymatic nitrationof phytophenolics: evidence for peroxynitrite-independent nitration of plant secondary metabolites. FEBS
Letters 533, 377-380 (2003).
10) Y. Sakihama, S. Murakami and H. Yamasaki. Involvement of nitric oxide in the mechanism for stomatal
opening in Vicia faba leaves. Biologia Plantarum. 46, 117-119 (2003).
11) M.F. Cohen, Y. Sakihama, Y.C. Takagi, T. Ichiba and H. Yamasaki. Synergistic effect of deoxyanthocyaninsfrom the symbiotic fern Azolla on hrm A gene induction in the cyanobacterium Nostoc punctiforme. Molecular
Plant-Microbe Interactions. 15, 875-882 (2002).
12) Y. Sakihama, M.F. Cohen, S.C. Grace and H. Yamasaki. Plant phenolic antioxidant and prooxidant activities:
phenolics-induced oxidative damage mediated by metals in plants. Toxicology. 177, 67-80 (2002).
13) Y. Sakihama, S. Nakamura and H. Yamasaki. Nitric oxide production mediated by nitrate reductase in thegreen alga Chlamydomonas reinhardtii: an alternative NO production pathway in photosynthetic organisms.
Plant and Cell Physiology. 43, 290-297 (2002).