Program November 13th 䠄Mon.䠅
9:00- 9:30

Registration

9:30 - 9:45

Opening
Chair: Yoshinori Sakurai, Ian Postuma

Session 1 – Physics

9:45-10:45

S1-1 Pablo Torres-Sánchez

On the upper limit of neutron energies suitable for BNCT

S1-2 Sakai Yusuke

Dosimetrically effective fast neutrons for boron neutron capture therapy(BNCT) of malignant melanoma

S1-3 Ricardo Luis Ramos

Thermal scattering libraries in neutron transport for BNCT dosimetry

S1-4 Ian Postuma

Neutron beam tailoring for clinical BNCT: from physical parametersoptimization to dose distribution evaluations in patient and in treatment room

10:45-11:05 Break

Chair: Hiroaki Kumada, Hanna Koivunoro

Session 2 - Accelerator System
S2-1 Hiroaki Kumada

Characteristic measurements for neutron beam of the linac-based neutron
source for BNCT device in University of Tsukuba

S2-2 Sergey Taskaev

Novosibirsk accelerator neutron source for BNCT

11:05-12:35 S2-3 Kazuki Tsuchida

Compact Accelerator-Driven BNCT System Used Sealed Lithium Target

S2-4 Wei-Lin Chen

Optimal Composition of LiF-doped Neutron Moderator in Li-target-based ABBNCTS2-5 Hanna Koivunoro

Comparison of nuBeam and FiR 1 neutron beam parameters

S2-6 Valeria Monti

Characterization of the linac based photonuclear thermal neutron source
E_LIBANS

12:35-13䠖35 Lunch
13:35-14:35 Poster Session 1

Chair: Hiroyuki Nakamura, Natsuko Kondo, Minoru Suzuki, Takushi Takata

14:35-14:40 Break

Chair: Hiroyuki Michiue, Andrea Monti Hughes

Session 3 - Biology 1
S3-1 Nicoletta Protti
S3-2 Tooru Andoh

BNCT irradiation of protein aggregates to evaluate the potentialities of NCT
in the treatment of Alzheimer’s Disease
Contribution of L-type amino acid transporter-1 in clear cell sarcoma toaccumulation of p-borono-L-phenylalanine in vitro and in vivo

14:40-15:40
BNCT preliminary studies in an oral cancer model that allows for the study ofS3-3 Andrea Monti Hughes tumor control, mucositis in precancerous tissue and development of second
primary tumors: Characterization of the 8-week cancerization modelS3-4 Hiroyuki Michiue

The next generation Boron agents with BSH fused Cell Penetrating Peptide
toward clinical application

15:40-16:00 BreakSession 4- Ongoing Projects and Future in BNCT Chair: Minoru Suzuki, Iiro Auterinen
S4-1 Yoshinori Sakurai
S4-2 Edyta DŝĐŚĂƑ
16:00-17:15
S4-3 Noah Smick
S4-4 Daniel Quah
S4-5 Iiro Auterinen
17:15-18:00

Present status and future plan for physical engineering and medical physics for
BNCT in KURRIINTERDYSCYPLINARY APPROACH TO THE BORON NEUTRON CAPTURE THERAPYAT MARIA RESEARCH REACTOR (POLAND)
Features and present status of the Neutron Therapeutics nuBeam™ BNCTsystem to be installed at Helsinki University Hospital
Would you pay from your own pocket to have Boron Neutron Capture Therapyin Japan? – A survey of Singaporeans
Global overview to the clinical BNCT facility development

Discussion 1㻟Poster Sessison 1
November 13th 13:35-14:35
Chair: Hiroyuki Nakamura

Seminor room 1&2

P1-1 Goeun Choi

Sodium Borocaptate Nano Drug Delivery System for Boron Neutron Capture
TherapyP1-2 CHUNLEI BI

Verification of boron compounds concentration measurement using LC/MS for
combination of boronophenylalanine (BPA) and borocaptate (BSH) in rat
plasmaP1-3 Tomáš Jelínek

New potential BNCT agent: Chemistry of [B10H10]2-P1-4 Jun KawamuraPreparation of boron cluster encapsulating liposomes using microflow system

P1-5 Satoshi Dowaki

Suppression of Melanoma Metastasis by Kojic Acid Modified Carborane

Chemistry

Chair: Natsuko Kondo
P2-1 Rui Akayama
BiologyP2-2 Yoshitaka MatsumotoP2-3 Kazuyo Igawa

Seminor room 1&2
Cell Survival and DNA-double-strand-breaks in Glioblastoma Cell Lines withDifferent p53 Status after Neutron Irradiation and Exposure to DNA-alkylating
Agent
Folate-modified cyclodextrin improves the intratumoral accumuration ofexisting boron compounds
Evaluation Scheme of Boron 10 Compound for Accelerator-based Boron
Neutron Capture Therapy

Chair: Minoru Suzuki
Medicine

Seminor room 1&2

P3-1 Takuya Fujmoto

Evaluation of Boron Neutron Capture Therapy for Leiomyosarcoma

P3-2 Keita Endo

Boron analysis and imaging by using Micro-W/yͬW/';WĂƌƚŝĐůĞ/ŶĚƵĐĞĚyͬɶ-ray
Emission㸧

Chair: Minoru Suzuki
MedicalPhysics

Seminor room 1&2

P4-1 Yi-Wei Chen

The impact of target positioning on dose in boron neutron capture therapy forbrain tumor

P4-2 Pei-Yi Lee

Dosimetry calculation for BNCT using medical image-based lattice models withcoarse and fine structures

Chair: Takushi Takata

Dosimetry

Seminor room 3&4

P5-1 Xingcai Guan

Performance study of the neutron flux monitors from 20 keV to 1 MeV using
accelerator-based BNCT neutron sources

P5-2 Moe Shinohara

Experimental verification of real-time gamma-ray spectrum / dose monitor Measurement in a fuel strage room-P5-3 Shingo Tamaki

Improvement of a liquid moderator based neutron spectrometer for BNCT

P5-4 Koki Tochitani

Gamma-ray dose measurement in neutron/gamma-ray mixed field using radiophotoluminescence glass dosimeter and two kinds of filter

P5-5 Kentaro Baba

GPU-based optical photon transport simulation system for the SOF detector
optimization

P5-6 M. El Ais

Monte Carlo study of a CdZnTe detector response to the neutron and gamma
background in a BNCT treatment roomP5-7 Agustina Portu

Enhanced resolution neutron autoradiography: UV-C sensitization of different
nuclear track detectors to form imprints of biological samples

P5-8 Carolina Vidal

BNCT-AR: Software development for the analysis of histological andautoradiographic images㻠Program November 14th 䠄Tue.䠅
Chair: Makoto Shirakawa, Vincent Jallet

Session 5 - Chemistry

9:00-10:15

10:15-10:35

S5-1 Makoto Shirakawa

Improvement of encapsulation method of boron compounds for development ofDDS formulation at high boron assembly

S5-2 Satomu Ishii

Development of disulfide-bridged boron cluster-maleimide (SSMID) andidentification of its conjugation sites on albumin

S5-3 Fumiko Nakagawa

Development of boron cluster containing water-soluble folate derivatives for BNCT

S5-4 Aoi Isono

Design and synthesis of new membrane permeable boron carriers for BNCT basedon the pepducin technology

S5-5 Vincent Jallet

Multifunctional silica nanoparticles for cancer treatment by BNCTBreak
Chair: Shoji Imamichi, Agustina Mariana Portu

Session 6 - Biology 2Radio-Sensitivity of Pimonidazole-Unlabeled Intratumor Quiescent Cells to ɶͲRays,

S6-1 Shin-ichiro Masunaga Accelerated Carbon Ion Beams and Boron Neutron Capture Reaction (BNCR)

10:35-12:05

S6-2 Shoji Imamichi

Investigation of biological effects of accelerator-based BNCT system in NCC

S6-3 Aleksandr Kichigin

Radiobiological studies on Vacuum Insulated Tandem Accelerator (VITA) for BNCT.
Accelerator-based neutron capture therapy: in-vitro efficacy evaluation and in-

S6-4 Alexander Zaboronok sample dosimetry using gold nanoparticles
S6-5 María Pedrosa

Neutron radiobiology experiments and new weighting factors for improving
Boron Neutron Capture Therapy treatment planningS6-6 Agustina Portu

BNCT + Electroporation: an autoradiographic analysis

12:05-13:05

Lunch

13:05-14:15

Poster Session 2

14:15-14:20

Break

Chair: Hiroaki Kumada, Hiroki Tanaka, Yoshinori Sakurai
Chair: Takushi Takata, Ming-Chen Hsiao

Session 7 - Medical Physics

14:20-15:50

15:50-16:10

S7-1 Haiyan Yu

Computational dosimetry study for the limb osteosarcoma case under
inhomogeneous structure and different voxel sizes

S7-2 Takushi Takata

Dosimetric Comparison of Total Scalp Irradiation in Boron Neutron Capture
Therapy Using Thermal and Epithermal Neutron Beams

S7-3 Katia Alikaniotis

BNCT neutron dose boost for brain tumors in radiotherapy

S7-4 Ryoichi Hinoto

Dosimetric influence of respiratory motion in lung boron neutron capture therapy

S7-5 Bill Park

Image guided patient positioning for the nuBeam™ BNCT system

S7-6 Takahiro Onishi

Evaluation of the dose given to a patient’s body outside the irradiation field forthe iBNCT neutron source

BreakChair: Natsuko Kondo, Yi-Wei Chen

Session 8 – Medicine

16:10-17:25

S8-1 Shin-Ichi Miyatake

Boron neutron capture therapy with the combination of successive bevacizumab
treatments for recurrent malignant gliomas -A pilot study.

S8-2 Natsuko Kondo

Re-irradiation by combination of boron neutron capture therapy and IMRT forradiation-induced glioblastoma: a case report

S8-3 Tien-Li Lan

Salvage Boron Neutron Capture Therapy (BNCT) for the First Case of Recurrent
Glioblastoma in Taiwan

S8-4 Teruhito Aihara

BNCT for Head and Neck Cancer : The history of our institution

S8-5 Minoru Suzuki

Boron neutron capture therapy (BNCT) for malignant thoracic tumors

17:25-18:05

Discussion 2

18:05-18:15

Break

18:15-20:15

Dinner㻡Poster Sessison 2
November 14th 13:05-14:15
Chair: Hiroaki Kumada, Hiroki Tanaka

Accelerator
SystemSeminor room 3&4

P6-1 Yuka Fujiwara

Development of an extended beam collimator for the linac-based neutron
source for BNCT in University of Tsukuba

P6-2 Daiki Furuzawa

Development of high heat removal technique for a sealed lithium target

P6-3 Kazuya Sato

Development of Beam Shaping Assembly for BNCT system in Nagoya University

P6-4 Masahiro Tanoshita

Pre-collimator Design for An Epi-thermal Neutron Source for BNCT Researcheswith A DT Neutron Source

P6-5 Naoto Hagura

A feasibility study of a new neutron-source facility by reusing the reactor pool
under decommissioning

P6-6 Alexandr Makarov

Diagnostics of the high power proton beam in a tandem accelerator withvacuum insulation

P6-7 ʤ͘Badrutdinov

Investigation of the long-term exposure of a high power proton beam on theTa-substrate of a neutron-generating target

P6-8 Alexey Koshkarev

Development and implementation of the automation system of the ion sourcefor BNCT

P6-9

Yaroslav Alexandrovich
Kolesnikov

Measurement of the space charge effect of a negative hydrogen ion beam

P6-10 ʤ͘BadrutdinovIn-situ observation of blistering during irradiation of metals by protons

P6-11 Ivan Shchudlo

Measurement of the emittance of negative hydrogen ion beam injected intovacuum insulation tandem acceleratorP6-12 Timofey Bykov

Data processing automatization for diagnostics of Budker Epithermal NeutronSource

P6-13 Jianfei Tong

Thermal-Hydraulic Design of Neutron Production Target for BNCT based on
3.5MeV RFQ Accelerator

P6-14 Chaobin Chen

R&D of BNCT in HEC

Chair: Yoshinori Sakurai

Reactor
SystemSeminor room 1&2

P7-1 BƵŬĂƐǌ Murawski

BNCT RESEARCH BEAM IN MARIA REACTOR (NCBJ, POLAND)

P7-2 Mikhail Anikin

Feasibility study of IRT-T core configuration optimization for BNCT

P7-3 Pavel Molodov

Modernization of IRT-T research reactor for BNCT applications

Chair: Yoshinori Sakurai
P8-1 K. Babaiyan

PromptP8-2 Alexander Winkler
Gamma-rayAnalysis

Seminor room 1&2
Design of PGNAA facility at TRR for boron measurement
Guide to spectra analysis with photon counting CdTe/ CdZnTe detectors inBNCT

P8-3 Kentaro Minami

Design of a proto-type array detector using GAGG scintillator for BNCT-SPECT

P8-4 Jun Goto

Study of charged particle activation analysis-ŽƉƚŝŵĂůĐŽŶĨŝŐƵƌĂƚŝŽŶŽĨɶ-ray detectors for a sample with strong backgroundfrom positron annihilation-

㻢Program November 15th 䠄Wed.䠅
Chair: Hiroki Tanaka, Alexander Winkler

Session 9 - Prompt Gamma-ray Analysis

9:00-10:30

S9-1

Hiroki Tanaka

Development of real-time neutron detector and prompt gamma-ray
imaging monitor for BNCT

S9-2

Matìas Valero

Simulation approach for the adequation of the detection region in thePGNAA facility design at RA-3

S9-3

Ryosuke Ohya

Experimental demonstration of real time measurement of 10B
concentration for BNCT

S9-4

Setareh Fatemi

Monte Carlo study of the imaging performances of a 20x20x20 mm3 CdZnTe
detector prototype

S9-5

Chunhui Gong

GPU-based Compton Camera imaging of prompt gamma rays for melanoma
case in BNCT

S9-6

Alexander Winkler

Tomographic reconstruction of a realistic 10B target in BNCT

10:30-10:50 Break

Chair: Naonori Ko, Dmitrii Alexandrovich Kasatov

Session 10 – Dosimetry

10:50-12:20

S10-1 Dmitrii Kasatov

Activation foil measuring on accelerator based neutron source

S10-2 Kiyotaka Akabori

A real-time neutron monitor for BNCT

S10-3 Ryohei Uchida

Investigation of applicability of polymer gel dosimeters with Li compounds
to dosimetry in boron neutron capture therapy

S10-4 James VohradskyEvaluation of silicon and diamond based microdosimetry for boron neutron
capture therapy applications

S10-5 Naonori Ko

Investigation of SOI microdosimeter in Boron Neutron Capture Therapy

12:20-12:35 Closing
12:35-Lunch㻣