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Hokkaido University Syllabus
Course Title
Organic Chemistry IIISubtitle

Instructor (Institution)
Takeshi OHKUMA ( Faculty of Engineering )Other Instructors (Institution)
Takeshi OHKUMA ( Faculty of Engineering )Taiga YURINO ( Faculty of Engineering )Open To Other Faculties /Schools

Course TypeYear

2020

Type of Class

LectureSemester
Number ofCredits

1stSemester

Course Number

016187

2

Year of Eligible Students

3～Eligible Department /Class
Numbering Code
Major Category CodeENG_ASE
Level Code3Middle Category CodeOK

Other InformationENG_ASE 3660
Major Category Title
Engineering_Applied Science and Engineering
Level
General Education Courses offered in upper years; Specialized Subjects (advanced)
Middle Category Title

6
Small Category CodeSmall Category Title

6Language TypeClasses are in Japanese.
Course list by the instructor with practical experiences
N/AKey Words
Carbonyl Compounds; Nucleophilic Addition Reactions; α-Substitution Reactions; Condensation Reactions

Course Objectives
Students will acquire fundamental knowledge of organic chemistry, which is necessary for learning synthetic organic chemistry,
polymer chemistry, and biochemistry, and then they will be able to understand the nature and transformation methods of organic
molecules. The lecture of organic chemistry consists of Organic Chemistry I, II, III, IV, and in Organic Chemistry III students willlearn basic idea on the properties and reactions including mechanisms of carbonyl compounds.

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Course Goals
Students understand the structure and properties of aldehydes, ketones, carboxylic acids, and carboxylic acid derivatives. They also
understand nucleophilic addition reactions, carbonyl condensation reactions, and the related reactions including reaction
mechanism comprehensively. Moreover, they can use the reactions as molecular transformation methods.

Course Schedule
1. Introduction of carbonyl compounds (1)Electronic structures, chemical properties, and general reactions of carbonyl compounds are introduced.
2. Nucleophilic addition reactions of carbonyl compounds (3)After learning the nomenclature, preparation methods, oxidation and nucleophilic addition reactions of aldehydes and ketones,their applications to organic synthesis are discussed.
3. Carboxylic acids (2)Nomenclature of carboxylic acids and their structural and chemical properties are introduced. Substituent effects on acidity andtypical reactions of carboxylic acids are examined.
4. Carboxylic acid derivatives (2)Typical reactions of acid halides, esters, amides, acid anhydrides, and nitriles are indtroduced.
5. α-Substitution reactions of carbonyl compounds (3)Acidity of hydrogen at the α-posirion of carbonyl compounds and formation of enolates are discussed. Typical reactions of enolates
are also introduced.
6. Condensation reactions of carbonyl compounds (4)Aldol condensation, Claisen condensation, Michael reaction, Robinson annulation, and the related condensation reactions areintroduced.

Homework
Preparation for the next lecture: It will be preferable to read the relevant contents in the textbook.
Review: Students review the contents based on the textbook and the lecture note. Students are sometimes required to submit
assignments. It will be preferable to solve some exercises on the textbook before the examination.

Grading System
The final grade will be determined students who attended above a certain number by depth of understanding and proficiency of thelecture contents on syllabus. Students must earn at least 60 points out of 100 to pass at the regular assignments (20%) as well asexaminations (80%).

Practical experience and utilization for classes

Condition of tasking the subject

Textbooks
有機化学（中）第９版 / John McMurry : 東京化学同人, 2017, ISBN:9784807909131

Reading List

Websites

Website of Laboratory
http://labs.eng.hokudai.ac.jp/labo/orgsynth/en/

Additional Information

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It is preferable that students have already earned credits of Organic Chemistry I and Organic Chemistry II.

Update2020/01/21 15:54:24

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