Consolidated Financial Result Briefing
for Fiscal Year ended March 31, 2023

CYBERDYNE, Inc.
May 15, 2023

Consolidated

nancial results (IFRS)
Year-on-year comparison for the scal year ended March 31, 2023
Revenue: 3,289M (+53% YoY)
Operating profit: ¥-1,145M (decreased 299M YoY)
Final profit: ¥-268M (Improved by 194M YoY)
(Unit: Millions of yen)

Revenue(Gross profit)

FY2021

FY2022

Q1-Q4

Q1-Q4

2,150

3,289

*1
+1,138 *1+52.9％ *1(1,462)(1,791)(+329)(+22.5%)-868

Operating profit-1,145

+/-

-277

+/-%

*２
*２

*1 Increase in revenue（1,138M）（YoY）
Rental +209M (HAL outside Japan)
Service +897M (Treatment service by RISE Group in USA)

*２ Increase in SG&A (619M) (YoY)
SG&A expenses of consolidated subsidiary acquired
through M&A +636M

ー*３ Investment securities 1,283M (Net)-379

Profit before tax

*３ *４
*３ *４

53

+433

ー

Finance income (gain on valuation) +1,248M
Finance expense -165
Gains related to CEJ +199M*４ Other -209M（Net）
Exchange loss -15M
Investment accounted for using equity method -195M*５

Profit attributable toowner of the parent

-492

-298

+194

ー

*5 Corporate tax 446M (YoY)
Tax effect on valuation gains 437M

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Consolidated nancial results (IFRS)
Performance trends【Q4 results】10% increase from Q3
Consolidated statementof profit or loss

FY2021
Q1-Q4(Unit : Millions of yen)

FY2022Q1Q2Q3Year on Year
Q4

Q1-Q4

+/-

+/- %

2,150

751

791

831

915

3,289

+1,138+52.9%

688

294

323

440

440

1,498

+809

+117.6%

1,462

457

467

391

475

1,791

+329

+22.5%

R&D expenses

713

151

182

161

241

735

+22

+3.1%

Other SG&A *Other income/expenses

1,787

535

562

551

** 757

2,406

+619

+34.6%

169

51

12

13

127

204

+34

+20.4%

Operating profit

-868

-178

-264

-307

-396

-1,145-277-

Finance income/expense

393

541

134

10

434

1,119

+726

+184.6%

Other

95

9

132

36

-97

79

-16

-17.0%

Profit before tax

-379

372

1

-261

-59

53

+433

-

Profit attributable toowner of the parent

-492

241

27

-200

-366

-298

+194

-

Revenue
Cost of sales *Gross profit* Transferred a portion of Other SG&Afrom FY2022Q1-Q3 to cost of sales due to a review of cost of services** Property tax 95M

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Consolidated nancial results (IFRS)
by types of transaction
Increase service sales by acquiring treatment service locations in the U.S.
3,289

1,421

(Millions of yen)

Services+897M

Income from treatment services in the U.S. +826M（+171%）

2,150
524

Sales
202
202

（+20%）

169

1,457

1,666

RentalIncrease of HAL rented outside Japan +241M+209M（+14%）
Service: Revenue from service at a point of time
Sales: Revenue from sales at a point of time

FY2021
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169

+33M

FY2022

Rental and maintenance: revenue over time6

Changes of rental revenue by each products
Growth of Medical Lower Limb Type (overseas) and Single Joint Type (domestic) rentals(Unit: Millions of yen)
Product classification
HAL Lower Limb Type(Medical)
HAL Lower Limb Type
(Non-medical)

FY2021
Q1-Q4

FY2022
Q1-Q4(Ratio)584

692 *１

42%

188

173

10%

HAL Single Joint Type132

180 *２

11%

Care support
and well-being

HAL Lumbar Type

251

238

14%

Labor Support

HAL Lumbar Type

98

65

4%

Cleaning/disinfection/transportation robot

51

53

3%

Other

174

265

16%

Total

1,457

1,666

100%

For Hospitals(improving function)*１ HAL Lower Limb Type (Medical)
The main factors of the increase in sales
were from APAC and Europe*２ HAL Single Joint TypeThe main factors of the increase in sales
were Japanese hospitals

7

Consolidated nancial results (IFRS)
by geographical region
Sigini cant increase of oversea sale +1,087M (30% to 53% of total revenue)• Significant increase in revenue due to the acquisition of treatment sites in the U.S.
• Increased sales in APAC 69% and EMEA 41%

Americas 11.4%
EMEA 9%APAC 10%

245M

191M

219M

Americas 34%

1,102M

Japan

Japan

70%
（1,496M）

FY2021
Americas: North, Central and South America
EMEA : Europe, the Middle East and Africa
APAC : Asia-Paci c * Revenue from Japan is stated separately

EMEA 8%APAC 11%

47%

270M

（1,547M）
370M

FY2022

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Ref) by geographical regions and type of transaction
Signi cant revenue growth in U.S. services and rentals in EMEA and APAC
(Unit : Millions of yen)

FY2022 - Q1-Q4(FY2021 - Q1-Q4)

Japan
Americas
EMEA
APAC

Total

RentalSales

Service

Total

1,092

158

297

1,547

(1,124)

(145)

(227)

(1,496)

31

17

1,054

1,102

(20)

(0)

(225)

(245)

204

0

67

270

(111)

(9)

(71)

(191)

340

26

4

370

(203)

(15)

(1)

(219)

1,666

202

1,421

3,289

(1,457)

(169)

(524)

(2,150)fi

9Pro t Structure: Strategies by Business Composition
for Sustainable Growth
Aim for CAGR (compound annual growth rate) of 30-40%(Unit: Millions of yen)

5,000

Expanding areas (Sales)
・Medical service for individuals (US)・Healthcare service for individuals (JP)4,000
3,289 (＋53％)*Utilize M&A

2,200
45%

3,000
1,500
44%

2,150 (＋15％)

Services(Flow/BtoC)

1,875
268
14%

2,000

524
24%

・Rental to medical facilities (APAC・EU)

55%
2,600
1,626
76%

1,607
86%

Reinforcing business (Pro t)

2,000
56%

1,000

・Rental to medical facilities in Japan

Rental etc.
(Stock/BtoB)FY2020
Actualfi

fi*Product sales are included in rentals, etc.

FY2021
ActualFY2022
ActualFY2023
Target10

Outlook for achieving operating pro tability
Factors Contributing to the Increase in Operating Loss
✅ Upfront investment in new businesses through acquired subsidiaries（Upfront investment will continue in FY2023）✅ Temporary delay in introduction of HAL at Japanese hospoitals due to COVID-19

Key points to achieve operating pro tability✅ Progress in the U.S. for medical, healthcare, and welfare services business✅ Continued expansion of HAL rentals to Europe and Asia
✅ Medical device approval and insurance listing of stroke and spinal cord injury in Japan✅ Other (expansion of cleaning/disinfection robot CL02, Vital Sensor “Cyvis” and commercialization of photoacoustic
imaging device “Acoustic X”)

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Outline of the business

12Realization of Techno-peer Support Society,

Where human and technology lives together and supports each otherPromote innovation that “leaves no one behind”
Maintain and manage their health even in old age and exercise their long-cultivated abilities tothe fullest even if they have a disability due to a decline in physical functions caused by disease,accident, or aging, they can live with a higher degree of independence.

Brain
Brain

Technology
Technology as
the new partner

Peer

Society
1.0

Society
2.0

Society
3.0

Society
4.0

Society 5.0/5.1

Promote healthy lives of many people with technology・・・aging, burdening-care

Physical space

Cyber space

Cybernics Space→ Create “Cybernics Industry”, a new industry that follows Robot and IT Industry
13

Cybernics Technology: Innovative core technology of Cybernics Industry*Cybernics:
New academic eld that fuses and combines
cross-disciplinary elds. It is centered aroundhumans, robots, and information systems, aswell as other elds.

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Integrated Cybernics System : Fusion of “Human” + “Cyber/Physical Space”
Realization of physical and informational interaction with 'people' to solve various issues in a super-aging society
Create a "Cybernics Industry" for people and society, focusing on medical care, welfare, daily life, workplace, and production
long-term care

Medicine

Cybernics Treatment

Vital Sensing

Promoting
Independence

Watch-overfor safety

Care
Support

Mobility
SupportLabor
SupportIntegrated
Cybernics System

Workplace

Daily life

Transportation
Production

Cleaning/sterilization
15

Innovation in the integrated space of “Human” + “Cyber/Physical Space”
Care

MedicalHospital

Care

Household

Daily life

Workplace

Workplace16

Main business model and revenue structure

For professional

For individuals(B to B)

(B to C)CYBERDYNE
Rental*1*2Service*1 Includes revenue fromsales and maintenances*2 Includes revenue from rental
17

C-Startup : Innovation ecosystem to create Cybernics Industry
University andresearch institutions

Cybernics Industry
bio/drug discovery

2020/12 listed

Start-ups andentrepreneurs

Med Tech

C-Startup

Big
Data

2022/6 M&A

regenerative
medicine

2022/12 listed

Cutting-edge
technology

Technical advices
Financial support
Business support

CYBERDYNE
Medical institutions,care facilities, companies,
allied partners

IoH/IoT
Robotics

AI

CEJ Fund (scale of 10 billion)

University, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the
21st century
Smart city council etc,.

2023.3.31 updated18

(Ref) Fair value assessment of strategic investment through “C-Startup”
Cumulative investment income 4.2 billion yen vs cumulative investment amount 11 billion yen
Realized gain: 510 million (4 companies)

Cumulative
investment income
Gain on valuation difference (PL)
3.9 billion (9 companies)

Cumulative investment amount
10.95 billion (31 companies)

4.21 billion*Unlisted equity securities are fair valued in accordancewith IFRS 9 "Financial Instruments**OCI (Other Comprehensive Income): Income notrecognized in net pro t or loss (PL)Realized loss (PL) 100 million (1 company)
Gain on valuation di erence (OCI **) 540 million (3companies)

Loss on valuation difference (PL) 660 million (2 companies)

Increase of fair value (16 companies +4.96 billion)

Decrease of fair value (3 companies -760 million)(Reference) Investments in which no valuation
di erences are currently recognized: 12 companies(As of the end of March 2023)

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Cybernics Medical Innovation BaseCreation of new treatment with Cybernics Treatment combined with regenerative medicine and drug discovery

Kingsky Front Tonomachi, Kawasaki
New base with a view to global expansion(5 minutes from Haneda Airport)

Haneda airport

Cybernics medical
innovation base2023/1- C-Startup partners began moving in
20

Cybernics Medical Innovation Base: Purpose
1) Combined Cybernics Treatment with Regenerative Medicine and HAL
While "Cybernics Treatment" using the world's rst Wearable Cyborg HAL is becoming a standard
treatment for functional improvement and regeneration of human brain nerves and muscles (HAL isalready available in 20 countries in Europe, the U.S., Asia, etc.), further therapeutic effects are expected
for severe patients by introducing technology at the cellular level and cell-produced substances. The
Group will promote the systemization of Cybernics Treatment at this research facility.

2) Integration of medical and bio-based technologies with AI, robotics, and information systems
In addition to deploying the Group's new-generation robotic bioreactor technologies and technologies
that integrate medical/biotechnologies with AI, robotics, and information technologies, the company will
provide research facilities to partner companies (medical/biotechnological companies and start-ups thatcan collaborate with the Company) and others to develop new medical technologies and expand theCompany's business.

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【Medical】Cybernics Treatment

CYBERDYNE, Inc.

22

Innovative Cybernics Treatment Technology
Wearable Cyborg HAL : Cybernics Treatment that induces functional regeneration
Signals from a person's brain nerve system are processed by signal processing and artificial intelligence inreal-time, HAL moves as if it were a part of the person's own body according to the person's intention

Medical1) HAL obtains information related to the brain nerve and muscles from the peripheral part of the body2) HAL synchronizes with the wearer’s intentions and functions according to the intention
3) Forms an interactive bio-feedback loop to induce improvement in the body-nerve and muscles systems,
achieving the goal of the Cybernics Treatment
23

【Medical】Cybernics Treatment (functional improvement/rehabilitation treatment)

Cybernics Treatment: Innovative method utilizing HAL for treating brain-nerve-musculoskeletal disorders

HAL Lumbar TypeHAL Single Joint Type

HAL Lower Limb Type24

Development pipeline (1)1) Medical HAL (Lower Limb Type)
Target disease

Product
Development

Clinical Trial(Exploratory)

Clinical Trial(Validation)

As of March 31, 2023

Application/
examination

Approval

Marketing(public healthinsurance in Japan)(Post-marketingsurveillance)

Public healthinsurance

Neuromuscular
Disease(8 types of diseasesuch as ALS)

Spastic paraplegia

PublicHealthInsurance

Approved(Expanded)(HAM etc.)

Spinal Cord Injury

Status
FY2022 revision (DPC calculation)
Public health insurance application(Germany)
Planning for public health insurance
Preparing for insurance application
Preparing application for expansion
Preparing application for expansion

Public medical
insurancecoverage forclinical trials

GermanPublic workers
Compensation
insurance

Discussing with the authorities
Preparing trial for public healthinsurance (Germany)
Planning for public health insurance
Planning additional trial

StrokePlanning for public health insurance
Planning for public health insurance
Investigator-initiated clinical trial

Cerebral Palsy

Multiple Sclerosis
Conducting pilot research

25

Development pipeline (2)２）Medical HAL (Single Joint Type)
Target disease

Product
Development

Clinical Trial(Exploratory)

Clinical Trial(Validation)

Application/
examination

As of March 31, 2023

Approval

Marketing(public healthinsurance in Japan)(Post-marketingsurveillance)

Public healthinsurance
PublicHealth Insurance

Neurology

StatusAdditional equipment for increased physical activity
Preparing for public health insurance（e.g. stroke)

Preparing for public health insurance

Preparing for public health insurance

Orthopedic

Preparing for public health insurance（e.g. after arti cial knee
replacement)

Preparing for public health insurance３）Medical HAL (Lumbar Type)
Target disease

Product
Development

Clinical Trial(Exploratory)

Clinical Trial(Validation)

As of March 31, 2023

Application/
examination

Approval

Marketing(public healthinsurance in Japan)(Post-marketingsurveillance)

Public healthinsurance

StatusConducting pilot trial

StrokeParkinsons
Disease

Preparing clinical trial

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Status of approvals by diseases and countries (1)Signi cant progress of legislation process in all regions
２）Medical HAL (Lower Limb Type)
StrokeUSA

Neuromusculardisease*As of March
31, 2023

Approved

Approved

Approved

ApprovedEU

Approved

Approved

Approved

Saudi Arabia

Approved

Approved

Approved

TurkeyThailandApproved
Approved
Approved
Approved

Approved
Approved
Approved
Approved

Taiwan(application in progress)

Singapore

Approved
Approved

Approved
Approved
Approved
Approved
Approved
Approved
Approved

Malaysia
Indonesia
APAC

Spinal Cord Injury(Discussing application method(Following the discussion with thewith the authorities)
authorities, considering additional trials) *Approved for viral (HAM) and hereditary(spastic paraplegia) spinal cord disease.

Japan

EMEA

As of March 31, 2023

Australia(application in progress)

Approved
Approved*Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophyfi27

Status of approvals by diseases and countries (2)Steady progress in medical devices legislation of Single Joint Type
２）Medical HAL (Single Joint Type)EMEA

Neurology（e.g. stroke）

Orthopedic（e.g. after arti cial knee replacement)

Japan

Certi cation*

Certi cation*

USA

Approved

ApprovedEU

Approved

Approved

TurkeyApproved

Approved

Saudi Arabia

Approved
Approved
Approved
Approved
Approved
Approved
Approved

Approved
Approved
Approved
Approved
Approved
Approved
Approved

Malaysia
Indonesia
APAC

As of March 31, 2023

ThailandTaiwanSingapore
Australia*As Japanese approval system separates “approvals” and “certi cations”, certi cation was used for accurate description

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Oversea expansion of HAL
Steady progress
in US, EU and APAC
after COVID
HALを使用したNeuro
HALFITを全国展開（全16箇所）
Yellow indicates new introduction areas after After the outbreak of COVID-19
New installation after April 2021
PolandConstance care

Germany*Covered by Public workers
compensation insurance
and private insurance*private insurance
coverage

Italy
Coopselios

EnglandState of Hampshire

California

FranceHospices Civils de Lyon

SerbiaTurkeyDiagenics

Spain
Switzerland

India
IBS Hospital

TaiwanCHC Group Hospital

FloridaBrooks Rehabilitation
Operated in 3 facilities

Philippines
4 facilities around
ManilaSaudi Arabia
ALJ Hospital

KuwaitSingapore General HospitalThailand

Malaysia
Operated in 10 facilities covered by public
workers compensation organization

Indonesia

BrazilAustralia
RoboFitOperated in 2 facilities

Large distribution of HTLV-1associated myelopathy (HAM)
infected individuals

As of March 31, 2023
29

®︎

BioCruces Bizkaia

RISE Healthcare Group(27 facilities)

Malaysia (1)Public Social Security System accelerates Cybernics Treatment dissemination in Malaysia

104 HALs rented for a fee
at 10 facilities in Malaysia
More locations to be added in the future

SOCSO (Malaysian Public Social Security Organization)
SOCSO has four functions: disability pension, survivor’s pension, medical
coverage and occupational injury coverage, and is compulsory for Malaysian
and foreign workers in Malaysia to join the program. It provides medical
compensation, disability compensation, funeral bene ts, child support andnursing care bene ts for illness or injury that occurs while commuting to andfrom work.

As of March 31 2023
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Malaysia (2)Largest medical complex in Southeast Asia “National Centre for Neuro-Robotics and Cybernics”

SOCSO constructs “National Neuro-Robotic and Cybernics Centre”
in the northern region of Malaysia
National Centre for Neuro-Robotics and Cybernics
It is being built in Bandar Meru Raya, a new area being
developed in Ipoh, Perak, northern Malaysia. It is expected
to cover an area of 37 hectares, and will be the largest
medical complex in Southeast Asia operated by SOCSO,
with the capacity to provide comprehensive treatment toabout 700 patients at the same time for a certain period oftime.
✅ Cybernics Treatment are highly evaluated outside Japan✅ Reinforce Cybernics Industry from this site

Planned to be completed at the end of 2024
31

Singapore
Installed to the largest medical institute in Singapore (Singapore General Hospital)
1) Obtained medical approval for HAL Lower Limb (December 2020)
2) Ships out HAL to Singapore General Hospital (July 2022)

Singapore General Hospital
The hospital is the rst and largest hospital in Singapore. It provides affordable specialist carefor patients, training for doctors and other healthcare professionals, and research to bring bettercare to its patients.Every year, the SGH Campus caters to over 1 million patients. With a 10,000strong workforce, SGH accounts for about a quarter of the total acute hospital beds in the public
sector and about one- fth of acute beds nationwide.

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Turkey
Gradually installs 36 units of HAL to private medical center (Diagenics)
19 units of HAL shipped out at the end of March 2023

Diagenics
The Diagenics Group was established to provide Precision Medicine
through the comprehensive use of innovative medical technologies,
including Cybernics Treatment utilizing HAL, Stem-cell therapy, andepidural stimulation therapy.

33

ItalySigned contract with social cooperative Coopselios
Shipping out 25 units of HAL *Revenue will be re ected on the 1Q of FY2023

Coopselios is a social service organization that has been active in
Italy for over 30 years including nursing homes, rehabilitation
centers, and children's homes. Coopselios has been providing
services to families, municipalities, and public health institutions in
Italy. Coopselios has been serving families, municipalities, andpublic health care institutions in Italy.
・3,550 professionals
・In 8 regions of Italy
・Providing services to 7,800 people everyday
Coopselios Headquarter in Reggio Emilia ‐ Italy
https://www.coopselios.com/uploads/2023/02/Ok-COOPSELIOS-GROUP-2022-ENG_de nitiva_SHORT-modalità-compatibilità.pdf

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Neuromuscular Diseases

CYBERDYNE, Inc.

35

進行性神経筋難病：市販後使用成績調査の結果

Performance test suggests high ef cacy and safety
Ef cacy

SafetyAmbulatory function remained above
level at the beginning of the treatment over long duration

Reduced damage to the muscle tissue

Distance covered in 2 min walk
(Rate of change from the level before HAL Treatment)

CK Blood Level* *Test to identify damage to the muscle(Rate of change from the level before HAL Treatment)

Improve 43%

BeforeHAL Treatment(=1)

Improve 30%

Improve 25%

Reduced 21%
Reduced 28%
BeforeHAL Treatment(=1)

Reduced 34%
Sample of decline ofAfter
13 months

After
25 months

After
37 months

After
7 monthsfunction over time

*Due to its progressive nature, typically ambulatory function will decline over timeAfter
19 months

After
31 months*Conventional exercise therapy will accelerate the damage on the muscle tissue

Target disease: Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis,
Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophy

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Information magazine for patients with intractable diseases
Published a magazine to support patients with progressive neuromuscular diseases and their families

Medical Supervisor: Takashi Nakajima, Neurologist
https://my.ebook5.net/cyberdyne/4i66VI/

37

Support website for patients
Launched a website to provide information to patients with neuromuscular diseases

Medical Supervisor: Takashi Nakajima, Neurologist
https://www.hal-treatment.jp38

Spinal Cord Injury

CYBERDYNE Inc.

39

Spinal Cord Injury: Clinical Trials by German Insurance Authorities
Clinical trials to be conducted on the premise of German public medical insurance coverage
G-BA (German Federal Joint Committee) decides to conduct clinical trials under the premise of insurance coverage
G-BA approves Cybernics Treatment as the standard of care to be considered for spinal cord injury patients (in accordance with §137eSGB V of the Study Regulations)
G-BA itself decides to conduct a clinical trial (the clinical trial will be covered by public health insurance for Cybernics Treatment in advance).
The results of the clinical trial are expected to be included in the German public medical insurance system.

G-BA Preparing Protocol Framework for Clinical Trials
2023/01 Protocol outline presented
2023/03 Expert hearing held

G-BA (Federal Joint Committee): Organization at the federal level that determines basic bene ts, prices, standards, etc. for German insurance treatment.
§137e SGB V (Trial Regulation): A system under which the G-BA conducts its own initiated clinical trials and makes nal evaluations of promising treatments that
could become the standard of care.

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Progressive spinal cord disease: expansion of indications
Additional indications: HTLV-1-associated myelopathy (HAM) and hereditary spastic paraplegia (approved)

Existing indication
Progressive neuromuscular diseases (8 diseases)

1. Spinal and bulbar muscular atrophy
2. Amyotrophic lateral sclerosis,
3. Spinal muscular atrophy
4. Charcot-Marie-Tooth disease
5. Inclusion body myositis
6. Distal muscular dystrophy
7. Congenital myopathy
8. Muscular dystrophy

Expanded indication (2022/10)
Progressive spinal diseases (2 diseases)

1.HTLV-1-related myelopathy
2.hereditary spastic paraplegia

Cybernics Treatment promotes the regeneration of neurological function in many diseases. It improves gait instability andfunctional disability caused by progressive intractable diseases for which no effective treatment has been established

41

StrokeCYBERDYNE, Inc.

42

Stroke: Initiatives towards obtaining approval
Additional trials for Medical HAL Lower Limb Type for stroke are under consideration in parallel withdiscussions with the authorities

As of March 31, 2023

Compared to 2014-2015, when investigator-initiated clinical trial for stroke (HIT2016 trial) was
conducted,conditions surrounding acute stroke treatment and recovery rehabilitation changed
signi cantly. Additional trials (clinical trials) to capture the latest patient pro le and clinical needs areunder consideration.
Based on discussions with the authorities regarding the clinical signi cance of the HIT2016 study andthe statistical signi cance of the primary endpoints, additional studies may have to be considered so
it can be submitted in combination with the results of HIT2016 study

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【Healthcare】Neuro HALFITCYBERDYNE, Inc.

44

Neuro HALFIT
Program to improve brain-nerve-musculoskeltal function at Robocare Center

HAL Lumbar TypeHAL Single Joint Type

HAL Lower Limb Type45

Robocare Center: Nationwide expansion of Neuro HALFIT
Expansion of hubs in the medical healthcare service business for individuals

Available in 17 locations
nationwide

46

HAL care prevention program
Signi cant improvement in mobility functions (daily activities such as standing, walking, running, sitting) of the elderly

Care prevention program (Kanagawa Mirai MIBYO Cohort Study)
Interim evaluation results of short-term intervention twice a week for a total of 10 sessions

Evaluation item

Before HAL

After HAL

(Mean±SD)10m walk (walking speed m/sec)

Locomotiv 5 check*Signs of motor unit deterioration(Mean±SD)

Improvement rate

P-value

1.04±0.22

1.45±0.25

39%<0.001***8.15±2.48

3.96±3.15

105%<0.001***）

Subject n=80 people (Average age : 74.8 ± 4.3 years old)
Research and development of nursing care prevention programs utilizing healthcare robotsfi

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Strategy for growth

CYBERDYNE, Inc.

48

Image of growth scenario
Towards gradual growth
Strengthening cloud computing,personalized business, M&A, etc.

Now(evolution of the business model, M&A)

Expanding existing business(expanding usage, business towards
individual users, etc.)

Developing the business base(Expanding product lineup, obtaining
regulatory approvals in eachcountries)

Time
49
fi

Businessscale

Reinforcing existing business,pioneering new eld

Future of medical healthcare and healthy life
Prevention/pre-symptomatic, medicine, rehabilitation/long-term care

Medical/Healthcare/Healthy life
Pre-Hospital

Hospital

Early medical・life period Prevent/pre-symptomatic

Diagnose, treat, inpatient/outpatientearly medical・life periodHousehold・work place・life space

Acute

RecoveryHospital

Post-Hospital
Late medical・life period : rehab/long-term care

Late medical・life periodHousehold・work place・life space

Squat

Squat

Close coordination, fusion between medical and non-medical field to evolve into comprehensive initiatives
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Cybernics Medical Healthcare System
Prevent, early detect and improve on daily basis (data linkage with Cyberdyne Cloud)Cybernics Medical Healthcare Systemthat prevent, early detect and improve on daily basis
Hospital, Facility, House, Workplaces

Cyberdyne Cloudwith innovative Cybernics System
Cybernics Treatment and monitoringat hospitals

Health care monitoringin daily life

Cloud
Computing

Improve independence to encouragecontinuous social activity

Sleep Apnea Syndrome,
sleep deprivation check

Activity,
sleeping check
Healthcare check and program to improvephysical function at home

Health Care Monitoring in the Workplace

Seamless data linkage between hospitals, facilities, homes, and workplaces with IoH/IoT
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Medicalcare Pit
Ef cient Cybernics Treatment with reduced therapist burden
Roboticized left-right
independent unloading control
Adjustment

If the body trunkleans strongly to one side
Weight-bearing
level set

The right and left are controlled
separately. If the trunk leans strongly to
one side, the weight reduction willautomatically be increased to adjust theleaning

Adjustment

Detection of leaning

Adjustment

If the body trunk
position drops

Weight-bearing
level set

The weight reduction will automaticallybe increased to get back to the original
position
Detection of dropped
positionfi

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Medical Healthcare Service for Individuals Neuro HALFIT at Home
Expansion of remote services connecting home and hospitals/facilities through cloud computingHouse（つーざー）

LTE/5G【Integrated Cybernics System】 LTE/5G

Physical information

Physical information(User)

Cybernics Device

Monitor tablet(User)
SupportUser authentication
Device authentication
Data baseRemote service to counter the pandemic

Physicalinformation

Physical information

Monitor tablet

Cybernics Device

SupportPhysical information

Facility

SupportInduceimprovement ofbrain-nerve andphysicalfunction

Physicalinformation

SupportSupport（つーざー）(professional)

Robocare Center

Robocare Center（CYBERDYNE）（つーざー）［Cloud］

SupportInduceimprovement ofbrain-nerve andphysicalfunctionHouse

Monitor tablet

Monitor tablet（CYBERDYNE）

Professional
Staff
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Medical service business for individuals: US Business (1)Promotion of in-house platform development of medical services for individuals

RHG（RISE Healthcare Group Inc.）

Northern California
Population: over 12.2 million(Company in charge of the Group's medical service business)✓

Gradual expansion in Southern California✓

Expansion to Northern California (February 2023)✓

Currently 27 locations (up 11 locations since thebeginning of the year)

A milestone in developing personalized
services, such as home functional
improvement and daily health care monitoringFirst base in Northern California
Monterey

State of California
accounts for 10% in theentire US population

LA Metropolitan area
Population: 13 million(2nd largest in US*)San Diego area

Population: 3.3 million(17th in US*)* https://en.wikipedia.org/wiki/List̲of̲core-based̲statistical̲areas

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Medical service business for individuals: US Business (2)Cybernics Treatment is gradually going to become a of cial service of the center✓ 4 facilities from Sep. 2022
✓ No. of treatment session from
Apr. 2022
Treatment sessions:1400+✓ High satisfaction✓ Combination of insurance andself-payment

WebMD wrote an article on Wearable
Cyborg HAL, following usage of a celebrity

https://www.webmd.com/a-to-z-guides/news/20230417/wearable-cyborg-may-be-the-future-of-physical-therapy

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【Prevention and early detection】Ultra small vital sensor Cyvis

Healthcare monitoring on daily basis with Cyvis
Daily accumulation, analysis, and AI processing of various vital data
・Cardiac activity
・brain activity
・body temperature
・SpO2
・Body movements
・Breathing (optional)

Check for arrhythmia and atrial brillation
to prevent myocardial infarction and cerebral infarction
Option to check breathing conditions during sleep for early detection of sleep apnea risk
✅ “Cyvis-1” applied for medical device legislation (Apr. 2022), Available on a trial basis for users✅ “Cyvis-2” applying for medical device legislation (Apr. 2023)fi

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【Prevention and early detection】Ultra small vital sensor Cyvis

Expands remote service that connects households to hospitals and facilities
House

Physical information（つーざー）(User)

User authentication
Device authentication
Data base

Induceimprovementof brain-nerve
and physicalfunction

Remote service to counter the pandemic

t
pp

or

t

Early
detection of
sleep apnea
syndromerisk

Facility(Professional)（つーざー）(User)
Monitor tablet

Mobile tablet

orSupportSupportpp

Su

Physicalinformation

Cyvis

Monitor tablet

Cybernics Device

al
ic on
ys atiPh rmfoinPhysicalinformation

Su

House

(User)
SupportInduceimprovementof brain-nerve
and physicalfunction

Early detectionof risks of
Cerebrovasculardisease, heartdisease, etc.

（つーざー）［Cloud］

SupportMonitor tablet

House

LTE/5G

Physical information

P
in hy
fo si
rm ca
at l
io
n

Cybernics Device【Integrated Cybernics System】

LTE/5GHouse（つーざー）(User)

Monitor tablet

Mobile tablet

Cyvis (Option)

Professional
Staff

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【Prevention and early detection】Photoacoustic Imaging Device using LED light array

Contrast-free, non-invasive, real-time, high-resolution 3D imaging
LED array method (patent held by the company)

Peripheral level examination,
which could not be done withconventional imaging
equipment, is now possible!
Example of application••
Adopted as the cover of
BioPhotonics, a U.S. industry
journal dealing with biophotonics••

Routine examination and diagnosis of
diabetic foot lesions
Examination of vascular regeneration
status by regenerative medicine
Examination and diagnosis of cancer
Examination of aging skin, etc.

Peripheral vascular and bloodconditions, etc.

Currently promoting medical device commercialization as a next-generation medical diagnostic imaging device
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【Prevention and early detection】Photoacoustic Imaging Device using LED light array

Introduced by prominent universities and research facilities around the world(e.g., Cambridge University, Stanford University, Johns Hopkins University, etc.)59

【Workplace】HAL Lumbar Type (Labor Support)
Visualization of workers' workload and physical condition (labor management and work ef ciency)
Active type andlight weight•

Can be worn for long hours

Construction sites,

Integrated
Cybernics System

airports, and distribution
warehouses etc.

Compact design• Can be used with safety belts (full-body type)(back won’t be covered)and air conditioning suits!

Able to move in midback position.
IoH/IoT device
Wearable Cyborg
Can be worn in 10 sec
Waterproof/dustproof(IEC reg, IP54)• Can be moved smoothly on siteLabormanager• Respond with assistance in a variety ofpractical tasks!

• Visualize workload analysis and operation status!
Integrated production management• It moves according to the wearer's
intention• Easy to put on and take off,•share with multiple people!
Can be worn outdoors,even in the rain!

Topics
Preparing a prototype of a new model
１）Slimming down even further
２）Further power and smooth assistance３）Visualization of vital andwork environment
60fi

Assist walking

【Workplace】Disinfection/Cleaning Robot CL02
Operationalizing next-generation technologies in a post-coronary society•
Extensive•
Cleaning ability •High speed autonomous navigation (Can safely clean at 4km/h to cover massive space in short time
Massive cleaning area (Detects wall that is 30m away and cover max 3,000m2 with full charge battery)High vacuum performance (one of the best in the industry)
Airports, o

CYCLES
Cloud & Server
ce buildings,

Cyberdyne
Cloud&Server

facilities, shopping
centers etc.

Can be used for •multiple tasks such •as disinfection••

Visualizes
its work

Disinfection agent sprayer (Disinfects handrails and benches)
UV Ray Disinfector (set on the bottom of the robot to disinfect oors)

Human

Dust distribution map (visualizes result of the task)
Navigated route (to create ef cient and effective cleaning plan)

RobotsAutomatically •rides on the•elevator

Elevator interface unit developed inhouse(Can connect to elevators developed by multiple vendors)
Can work on multiple oors (Expands the space that can be cleaned)

Information transfer
and remote control

Topics１）Can now work in o ce buildings(Interlocking with building systems)•

Cloud linkage•“CYCLES” designed for the Robot(realizes high usability and management)
Integration with the base system

２）Expansion of mobility applications(Transport robots in factories, etc.)

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SDGs for Society 5.0/5.1

CYBERDYNE, Inc.

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Four projects that contributes to achieving SDGs

Develop Cybernics Technology tosupport people with reduced
physical function

Health Risk Management with
Cyberdyne Cloud

Main initiatives

Main initiatives• Disseminate Cybernics Treatment that
promotes functional improvement andregeneration of the brain, nervous system,
and muscular system using a Wearable
Cyborg HAL, as a global standard treatment• Develop Cyberdyne Cloud to accumulate,analyze, and perform AI processing of big
data on people and things (IoH/IoT big data)obtained through all Cybernics Technologies
equipped with communication functions• Disseminate Wearable Cyborg HAL to
improve the level of care required by theelderly and prevent severe illness and prevent
frailty and maintain independence as physicalfunctions decline with age• Realize personalized healthcare throughCyberdyne Cloud• Develop Cyin for Living Support for people
with severe disabilities who cannot speak orwrite as they wish due to the progression of
intractable diseases to communicate andoperate machines without speech or physicalmovement• Develop sensing technology to monitor vital
information daily• Develop HAL at Home as a new service thatcan share user's information on their training
sessions conducted at home using HAL withmedical and care facilities

Form social infrastructure tocreate the Cybernics Industry
Main initiatives• Establish a system to support companies andhuman resources that develop and deploy
technologies and services that solve social
problems• Construct Cybernics Innovation Base topromote innovation in the medical andbiotechnology elds
• Continue the projects at the Next-generation
multi-purpose robotized production facility to
induce innovation in the production eld

Realize Society 5.0/5.1, a futuresociety that accelerates innovation
Main initiatives• Develop mobility technologies that are safe,
affordable, and ready for use by all people• Develop a future city where all people, including
the elderly and disabled, can easily access public
spaces.
• Establish educational institutions that develop
knowledge and skills to help people.
• Create shared spaces that promote innovationand scienti c research and areas for eld testing

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Develop Cybernic Technology to support people with
reduced physical function
Our contribution

Main target
10.2 by 2030 empower andpromote the social, economic
and political inclusion of allirrespective of age, sex,
disability, race, ethnicity,
origin, religion or economic orother status

By developing the Wearable Cyborg HAL for medical and welfare elds, andCyin for Well-being to support severely disabled to communicate theirintentions, we are supporting the elderly and disabled person by
maintaining and improving their functions. We also help them express what
they have in mind.
We also develop another type of HAL to support people engaged in heavy
work.
This project promotes the empowerment of these people and their social,economic, and political inclusion.

Disseminating Medical HAL as a
global standard treatment
As of the end of March 2023, HAL for
Medical Use is available in 20
countries and regions, includingSoutheast Asia and South Asia, as atreatment technology for stroke,
spinal cord injury, and intractableneuromuscular diseases.
In addition, to contribute to solving
the needs of developing countries,
we have been selected by the Japan
International Cooperation Agency(JICA) to conduct a research projectin Brazil.
We will continue to disseminate thetechnology.

Post-discharge care at the
Robocare Center

Cybernics Treatment Center andMedical HAL

HAL Lumbar Type to support
various heavy work

Cyin for Living Support to support severely
disabled person on their communication

For those who want to keep
improving their physical functions
after they get discharged from thehospital, we offer Neuro HALFIT at
self-funded rehabilitation facilities
called RoboCare Center. As of theend of March 2023, they are 17
centers around Japan. A user canalso access similar programs at selffunded rehabilitation facilities withwhich we have cooperative
relationships.
In addition, we have formed
alliances with private insurancecompanies such as Daido Life, AIG
Insurance, and Sompo Japan tocover the cost of such programs fortheir policyholders.
We will continue our efforts toimprove physical and economic
access.

Improving the working environment
Job turnover due to the onset of backpain and the deterioration of
performance caused by frequent
heavy lifting is becoming a signi cantissue in nursing care, construction,and logistics.
The Company develops HAL
Lumbar Type to reduce the risk ofdeveloping back pain by reducing theload applied to the lower back. The
technology empowers people
engaged in heavy lifting and enables
the worker to continue working longer
and safer.
As of the end of March 2023, 1,557
units of HAL Lumbar Type were in
operation.
This product is currently available inJapan and the UK. We will continue
to disseminate the technology tomore countries and regions.

Supporting communication for theseverely disabled
We develop Cyin for Living Support,
which enables people with severe
disabilities who cannot speak or movetheir bodies due to the progression of
intractable diseases to communicate
and operate devices.
The product is available on themarket. Daido Life Insurance donatedthe product to several patient groups
and patient support groups to promote
this endeavor.
We will continue to work on additional
functions and offer the product outsideof Japan once it is ready.

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Our contribution

Release of Cyberdyne Cloud

Cybernics Technology deployed in various elds such as medicine, nursingcare, production, and other workplaces with households, integrally connects
people's internal information (brain nerve information, physiologicalinformation, etc.), people's external information (behavioral information,
lifestyle information, etc.), and environmental information with asupercomputer.
The Company works on the system that accumulates, analyzes, and AI
processes all the IoH/IoT Big Data obtained through this process,contributing to personalized medicine, early warning of health risks, andenhancing risk mitigation and risk management capabilities.

Main target
3.d Strengthen the capacityof all countries, in particulardeveloping countries, forearly warning, risk reduction
and management of nationaland global health risks

The Company develops Cyberdyne
Cloud to connect different elds andprovide feedback on health risks
based on IoH/IoT Big Data. In Japan,
a system that allows users to send
information on their training sessions
from home to a facility and receive
timely support from the facility isalready in operation from November
2020.
We will continue to expand thissystem to other elds according to
the development of products andservices. We will also offer thesystem outside Japan to contribute tohealth management in all countries,
including developing countries.

Realizing personalized
healthcare
Cybernics Medical Healthcare Systemthat prevent, early detect and improve on daily basis“Hospital”, “Facilities”, “Household”, “Workplaces"

Cybernics Cloudwith innovative Cybernics System

Cybernics Treatment andmonitoring at hospitals

Health care monitoringin daily life

Cloud
Computing

Improve independence toencourage continuoussocial activity

Sleep Apnea Syndrome,
sleep deprivation check
Activity,
sleeping check

Healthcare check and program to improvephysical function at home

By accumulating, analyzing, and AIprocessing IoH/IoT Big Data related
to a single user across different
elds, we will realize personalized
healthcare that will maximize theeffect and safety of that user.
This initiative is being carried out
simultaneously with the formation of
IoH/IoT Big Data for all users. We willcontinue to expand this system toother elds according to thedevelopment of products andservices. We will also offer thesystem outside Japan to contribute tohealth management in all countries,
including developing countries.

Developing vital sensing
technology
In addition to developing the
Wearable Cyborg HAL andautonomous navigation technology,
we are developing sensing
technology to prevent and detect
diseases.
For example, commercialization ofCyvis, an ultra small-sized vital
sensor to detect arteriosclerosis andarrhythmia at an early stage, and aphotoacoustic imaging device toenable real-time analysis of capillary
information.
By promoting these products, we willaccumulate important vital
information that will lead to theprevention and early detection of
diseases, thereby contributing to theenhancement of capabilities forhealth risk management.

New service: HAL at Home
HAL at Home is a new service thatenables safe and effective training at
home. HAL at Home also realized thevisualization of exercise information
and remote online support by
professional staff through HAL's builtin communication functions.
The Company is also working to
expand home visiting services so that
seniors who have concerns about
handling digital devices can also
engage in the program.

Health Care Monitoringin the Workplace

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Health Risk Management with Cyberdyne CloudOur contribution
We are working to create an inclusive and sustainable industry called
Cybernics Industry by building an innovation ecosystem called C-Startup
and facilities to accelerate innovation in medicine/biotechnology andproduction.
C-Startup, the foundation for the creation of new industries

Main target
9.2 Promote inclusive andsustainable industrialization
and, by 2030, signi cantly
raise industry’s share of
employment and grossdomestic product, in line withnational circumstances, anddouble its share in least
developed countries

C-Startup is an innovation ecosystem to create a new industry for solving problems ofpeople and society: Cybernics Industry. We work together with startups and entrepreneurs
with similar visions, regardless of their nationalities.
We accelerate creating the Cybernics Industry by providing technical advice by Yoshiyuki
Sankai (CEO of CYBERDYNE/Professor of Tsukuba University) and nancial support by
CYBERDYNE and its related Fund.
As part of this initiative, we have formed partnerships with a total of 31 startups andhave invested over 10 billion yen in accumulation to support this endeavor.
Cybernics Industry

University andresearch institutions

Promoting the vision of the Cybernics
Industry
The Company promotes the vision of the
Cybernics Industry, a new industry that fuses
Human and Cyber/Physical Space, both
domestically and internationally. With thisinitiative, we are leading the efforts to form
Cybernics Industry together with industry,
academia, and government.
For example, in 2023, we communicated thisvision to various countries at the G7 Digital andTechnology Ministerial Meeting held in Takasaki
City, Gunma Prefecture.
We will continue to share our vision of the
Cybernics Industry as a foundation for industrial
and technological innovation.

Start-ups andentrepreneurs

bio/drug discovery

Med Tech

2020/12 listed

C-Startup

regenerative
medicineBig
Data

Technical advices
Financial support
Business support

2022/12 listed

Cutting-edge
technology

IoH/IoT
Robotics

CYBERDYNEAI

CEJ Fund (scale of 10 billion)

University, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the 21st
century
Smart city council etc,.

Medical institutions,care facilities, companies,
allied partners

2022.9.27 updated

G7 Digital and Technology Ministerial Meeting (2023)

Construction of Cybernics Medical Innovation Base

Exterior image

We plan to construct the Cybernics Innovation Base in
Kawasaki City, Kanagawa Prefecture, as a facility toaccelerate innovation in the medical and biotechnology
elds. The facility will house a cluster of medical andbiotechnology ventures. The Company, universities, andresident companies can conduct a clinical trial in thefacility independently and through collaboration.
The facility commenced operation in 2023.

Activities at the Next-Generation
Multipurpose Robotic ManufacturingBase
In Koriyama City, Fukushima Prefecture, we haveconstructed a next-generation production base to
produce robots and devices with Cybernics
Technology. In this facility, the Company
embedded the skills of experienced workers into
the robots so the robots and human workers canwork in harmony.
The Company constructed the facility in 2016
and completed a registration to manufacture
medical devices in 2020.

Exterior of the facility

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Form social infrastructure to create the Cybernic Industry

Realize Society 5.0/5.1, a future society that accelerates innovation
Our contribution
Using innovative Cybernics Technology, we promote the fusion of Humanand Cyber/Physical Space to create Society 5.0/5.1. We envision this futuresociety as a techno-peer-supported society where technology and human
support each other as partners.
Creation of Society 5.0/5.1

Main target
11.2
by 2030, provide
access to safe, affordable,
accessible and sustainabletransport systems for all,i m p r o v i n g r o a d s a f e t y,notably by expanding public
transport, with special
attention to the needs ofthose in vulnerable
situations, women, children,
persons with disabilities andolder persons
11.7
by 2030, provide
universal access to safe,
inclusive and accessible,
green and public spaces,
particularly for women andchildren, older persons andpersons with disabilities

Society 5.0 is a concept rst proposed in Japan's Fifth Science and Technology Basic
Plan as the ideal future society. In this society, science and technology connect all people
and things, sharing various knowledge and information to create new values never seen
before.
We contribute to the creation of Society 5.0 by implementing Cybernics Technology inthe various business elds to integrate internal information (brain nerve information,
physiological information, etc.), people's external information (behavioral information,
lifestyle information, etc.), and environmental information with a supercomputer. As one of
the leaders in this challenge, we work to explore the society beyond Society 5.0/5.1.

Mobility Infrastructure

Futuristic housing

We are working on personal mobility
and drones for transportation that issafe, inexpensive, and easy to use,taking into consideration the needs ofthe elderly and disabled living in thecommunity.
We are also planning cities basedon the premise of introducing
mobility, which will shorten travel timeand create new connections andadded value between functions andfacilities.
While developing mobility
infrastructure in-house, we are alsocollaborating with startups that aredeveloping related technologies.

Through daily health management
and lifestyle support infrastructure
based on Cybernics Technology, we
will develop housing where all
people, including the elderly anddisabled, can live in harmony withtechnology and mutually support
each other to ensure peace of mind.
Speci cally, various Cybernics
Technologies, such as the Wearable
Cyborg HAL, autonomous navigation
robots, and vital sensors, will be
introduced into every space,including residences. Personal healthinformation will be accumulated,
analyzed, and processed by AI to belinked to medical facilities to manage
each person's health and safety
better.

Shared Economy
We plan to shift from the conventionalmodel of occupying information,
people, goods, space, and time to a
new form of a city where we can shareand help each other.
We will work to achieve successwith the allies formed in C-Startup. We
will also continue to gather people andcompanies with seeds related to
Cybernics and accelerate the creationof innovation through sharing andmutual aid of information, people,
goods, space, and time.

An educational institution that
nurtures the next generation ofhuman resources
Through collaboration between
industry, academia, and government,
we are planning an educational
institution to foster the next generationof innovators.
We will nurture the next generationof innovators with educational
institutions ranging from graduate
school to elementary school, taught by
instructors from various companies.

perspective drawing of the future city

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Disclaimer

This presentation contains forward-looking statements concerning
CYBERDYNE, Inc. and its Group’s future plans, strategies and performance.
Forward-looking statements contained in this presentation are based on
information currently available and on certain assumption redeemed rational at
the time of creation of this presentation. As such, due to various risks anduncertainties, the statements and assumption does not guarantee future
performance, may be considered differently from alternative perspectives andmay differ from the actual result.
Further, this presentation contains statements and information regarding
corporate entities other than those belonging to the CYBERDYNE group, whichhave been complied from various publicly- available sources. CYBERDYNE
does not verify nor guarantees accuracy and appropriateness of those
information.

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