HiPep Laboratories Product Infomation

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HiPep Laboratories oﬀers innovative and unique products concerning research tools in the ﬁeld of drug-discovery and development including
library constructions. Numerous products (most of them are originally prepared by us) are exhibiting in our web-site

Many products are oﬀers
upon customers needs.
Flow for new drug
development
Identiﬁcation oftarget molecules
Construction ofcompound libraries
Identiﬁcation andcharacterization oftarget molecules
for drugs

Identiﬁcation ofnovel drug candidates
Screening
Optimization

Peptides immobilized on
gel-type polymer support
Cyclic peptides (diversity: ca 200 millions)immobilized on gel-type beads, one peptide on
one bead, consisting of 19 natural and 5 nonproteinogenic amino acids. Discovery of target
recognizing elements. Explore recognized sequences.
ex. Human cancer cell surface protein recognition

protein162beads

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SchemeTelomere staining probe
PIPA (Product Name HPTH59) is the optimal probe
for telomere visualization ,commercialized !
The ﬂuorescent labeled HPTH59 is nuclease resistantand enters into cell nuclei without any deliverysystems and direct visualization and quantitation oftelomere is possible. Denaturation is not required.

Preclinical tests

product catalogs andtechnical information
can be downloaded
from our web-site.

Prion protein
related peptide library
R&D tools for therapeutics and/or diagnostics
agents. These peptides can discriminate structuralchanges of prion proteins.
The novel assay method for prion strains had
been developed.
The interactions ofdesigned peptides andinfectious prion has
been investigated.

DNA-recognition by PIPAs

Novel therapeutic agents as
gene silencers or DNA-speciﬁcprobes/ DNA-visualization（diagnostics).
①Stable in cells or bodies②Speciﬁcally binds to the target ds DNA③Enter into cell nucleus without any DDS④Flexible Design against any gene.
⑤No-toxicities⑥Targeting: not possible by small molecules orantibodies*GMP production is underway.

Toxicity tests

Clinical trial

http://hipep.jp/eng/

Mimosine

Peptide (AGP)

Mimosine, non-proteinogenic amino acid & Mimosyl
Peptides as ingredients for cosmeceuticals or
pharmaceuticals. A large scale extraction,
puriﬁcation, physicochemical characterization ofhigh quality Mimosine from plant Leucaena
de Wit has been established.

Angiogenic peptide (AGP) had been discovered
which can be applied to regenerative medicine(PAT in JP, US and EU).

HiPep Laboratories
Contract based Research, Syntheses, Characterization by using in housedeveloped materials/devices and world top level instruments
・Libraries: Design, Synthesis and Construction of Peptide/ Polyamide derivatives, and Bioconjugates: Design, syntheses andcharacterizations: High quality peptides containing not only natural amino acids but also non-proteinogenic amino acids, Glycopeptides,
Nakatsukasa-cho, 486-46, Kamigyo-ku,

Lipopeptides, Cyclic peptides, Phosphopeptides, Sulfated peptides, Glutathione derivatives (metabolites), Pyrrole-imidazole polyamides,

Kyoto, 602-8158, Japan

Peptide Nucleic Acids, Protein syntheses by chemical ligation, Cell penetrating peptides, Peptide-Vehicles for DDS

TEL: 075-813-2101
FAX: 075-801-0280

HiPep・Analyses: Amino acid composition, Determination of residual organic solvents/acids, water contents, Chiral analyses = GMP-GLP approved
・Characterization: LCMS, MS/MS, MALDI-TOF-MS/MS
・Microarray printing services: Utilizing the most advanced facilities and expertise on patented concepts with novel substrates made from
amorphous carbon and/or high quality glass substrate slides (operated in the class 100 clean room)
・Biochip detection service: Fluorescent scanner or a ﬂuorescent microscopy, further MALDI-TOF-MS