Name
Chikashi TERAO
Office Address
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045,
Japan
TEL:(+81) 45-503-9111
FAX:(+81) 45-503-9113
Email: cterao@riken.jp
cterao@u-shizuoka-ken.ac.jp
Date of Birth
26 October 1979
DegreeM.D., Ph.D.
Nationality
Japan
Education
2004

M.D.

Kyoto University, Kyoto, Japan

2011

Ph.D.

Kyoto University Graduate School of Medicine, Kyoto, Japan

Post Doctoral Training
2011-2014

Kyoto University Graduate School of Medicine, Kyoto, Japan (Dr. Matsuda)

2014-2017

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA (Dr.
Raychaudhuri)

Faculty Academic Appointments
2011-2017

Assistant Professor

Kyoto University Graduate School of Medicine, Kyoto, Japan2017-

Senior Research Scientist

Laboratory for Statistical Analysis, RIKEN Center for

Integrative Medical Sciences, Yokohama, Japan
Professor

The School of Pharmaceutical Sciences, University of Shizuoka

Appointments at Hospitals
2004-6

Resident, Shiga Medical Center for Adults, Shiga, Japan

2006-14

Attending Physician, Department of Rheumatology and Clinical Immunology, Kyoto
University Hospital, Kyoto, Japan

2008-2014

Attending Physician, Department of Rheumatology, Japanese Red Cross Wakayama
Medical Center, Japan

2017-

Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan

Other Professional Positions
2005-6

Teaching Assistant, Department of Rheumatology and Clinical Immunology, Kyoto
University Hospital, Kyoto, Japan

2010-11GCOE Associate Fellow, Department of Rheumatology and Clinical Immunology, Kyoto
University Hospital, Kyoto, Japan

Teaching and mentoring
Lecture for undergraduate students 2006-2010
Lecture for graduate students 2011, 2014
Yuji Narumiya (2011-12)
Kosuke Tanaka (2013-14)
Tanaka et al, J Hum Genet. 2014 (Publication#25)
Kazuya Setoh
Setoh et al, Nat Commun. 2015 (Publication#45)
Shuji Akizuki
KAKENHI 16K09891
Ai Yaku (2015/4~)
2016 The Kyoto University Foundation Travel Grant
Yaku et al, Sci Rep. 2017 (Publication#59)
Hideaki Tsuji (2015/4~)
2016 The Kyoto University Foundation Travel Grant
2016 EULAR Travel Award
Tsuji et al, Sci Rep. 2017 (Publication#65)
Ryosuke Hiwa (2015/4~)
Hiwa et al, J Rheum. 20172016 JCR International Workshop Award
Nobuo Kuramoto (2015/4~)
Kuramoto et al, Sci Rep. 2017 (Publication#66)
2016 JCR International Workshop Award
2016 The Kyoto University Foundation Travel Grant
Reviewer for Journals

Annals of Internal Medicine
Annals of the Rheumatic Diseases
Arthritis and Rheumatology
Autoantibodies
BMC Medicine
BMJ Case Reports
Clinical Rheumatology
Endocrine Journal
Heart Vessels
Human Immunology
Hypertension
Immunology Letters
International Immunology
International Journal of Infectious Diseases
International Journal of Rheumatic Diseases
Journal of Human Genetics
Journal of Genetics
Journal of Rheumatology
Medicine
Modern Rheumatology
Modern Rheumatology Case Reports
Nature Reviews Rheumatology
PLoS ONE
Rheumatology (Oxford)
Rheumatology International
Scientific Reports
Honors and Awards
2009

GCOE Travel Award, Kyoto University
EULAR Travel Award, EULAR (European League Against Rheumatism) Congress 20092010

BD Japan Young Investigators’ Travel Award, 14th International Congress of Immunology

2011

Kyoto University Young Investigator Step-up Grant
GCOE Travel Award, Kyoto University
EULAR Travel Award, EULAR (European League Against Rheumatism) Congress 2011
EULAR Abstract Award, EULAR (European League Against Rheumatism) Congress 20112012

GCOE Travel Award, Kyoto University

2013

Japan Rheumatism Foundation Travel Grant
The Kyoto University Foundation Travel Grant

The Kato Memorial Trust for Nambyo ResearchMochida Memorial Foundation for Medical and Pharmaceutical Research
Japan Intractable Diseases Research Foundation
Japan Research Foundation for Clinical Pharmacology
Outstanding presenter award at the 41st Annual Meeting of the Japan Society for Clinical
Immunology
Nagao Takeshi NANBYO Research Foundation
2014

JCR 2014 International Workshop Award
APLAR 2014 travel award
Japan Rheumatism Foundation
APLAR AbbVie Best Abstract Award at the 16th Asia Pacific League of Associations forRheumatology Congress
EULAR travel award, EULAR (European League Against Rheumatism) Congress 2014
The John Mung Advanced Program, Kyoto University

2015

Research Fellowship for study abroad, The Uehara Memorial Foundation
The 43rd KANAE Grant, The Kanae Foundation for the Promotion of Medical Science

2016

The Cardiovascular Research Fund, Tokyo, JapanEULAR travel award, EULAR (European League Against Rheumatism) Congress 2016
APLAR 2016 travel award
Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental University
Young Investigator Okamoto Award2017

JCR (Japan College of Rheumatology) Young Investigator Award
Sakakibara Memorial Research Grant
Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental University
JSHG (Japan Society of Human Genetics) Young Investigator Award

Honors and Awards for junior researchers during mentorship2016

JCR 2014 International Workshop Award (to Ryosuke Hiwa)
JCR 2014 International Workshop Award (to Nobuo Kuramoto)
EULAR travel award, EULAR (European League Against Rheumatism) Congress 2016 (to Hideaki
Tsuji)The Kyoto University Foundation Travel Grant (to Ai Yaku)
The Kyoto University Foundation Travel Grant (to Nobuo Kuramoto)
The Kyoto University Foundation Travel Grant (to Hideaki Tsuji)Funding Information
2011-2012

Genetic analysis of responsiveness to tocilizumab in rheumatoid arthritis
Kyoto University Young Investigator Step-up Grant
Role: PI
Annual Direct Cost: $13,500
The major goal of this study is to determine genetic variation associated withresponsiveness to tocilizumab, humanized anti-IL-6 receptor antibody, in rheumatoid
arthritis.
Completed

FY2013-FY2014 Integrative omics analysis for Takayasu arteritis
Grant-in-Aid for Young Scientists (B) from The Ministry of Education, Culture, Sports,
Science and Technology
Role: PI
Annual Direct Cost: $16,000
The major goal of this study is to detect critical gene, transcript, metabolite, protein, andpathway for the pathophysiology of Takayasu Arteritis.
Completed2013-2014

Elucidation of pathophysiology of systemic sclerosis by analyzing PLD4-mutant or KO
mice
The Kato Memorial Trust for Nambyo Research
Role: PI
Annual Direct Cost: $20,000
The major goal of this study is to analyze fundamental mechanisms of systemic sclerosis
by focusing on novel susceptibility gene to SSc, PLD4. We will assess immunologicalchange in PLD4-mutant or –deficient mice.
Completed2013-2014

Multi-ethnic genome-wide association study for Takayasu arteritis
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Role:PI
Annual Direct Cost: $30,000
The major goal of this study is to perform multi-ethnic genome-wide association study for
Takayasu arteritis to elucidate genetic background of Takayasu arteritis. We are planningto perform GWAS using Asian and Caucasian population.
Completed2013-2014

Functional analysis of susceptibility gene to Takayasu arteritis and develop novel therapy
for Takayasu arteritis
Japan Intractable Diseases Research Foundation
Role:PI

Annual Direct Cost: $20,000
The major goal of this study is to perform which genes of the susceptibility region on
chromosome 17 to Takayasu arteritis is responsible to the disease susceptibility andconduct a clinical study to apply new therapy for this intractable disease based on GWAS
results.
Completed2013-2015

Prospective study to prevent anti-thyroid drug-induced agranulocytosis in Graves’ disease
Japan Research Foundation for Clinical Pharmacology
Role:PI
Annual Direct Cost:$10,000
The major goal of this study is to develop algorithm to prevent anti-thyroid drug-induced
agranulocytosis in Graves’ disease based on genetic data and initiate a prospective study.
Completed2013-2014

Identifying susceptibility genes to connective tissue disease-associated pulmonary arterial
hypertension through multi-ethnic meta-analysis of systemic sclerosis
Nagao Takeshi NANBYO Research Fundation
Role:PI
Annual Direct Cost:$10,000
The major goal of this study is to determine susceptibility genes or variants to pulmonary
arterial hypertension in patients with connective tissue disease, especially systemicsclerosis by multi-ethnic meta-analysis of genome-wide association study.
Completed2014-2015

Investigation of clinical importance of IL12/23 in patients with Takayasu arteritis andfunctional analysis of variants in IL12B.
Japan Rheumatism Foundation
Role:PI
Annual Direct Cost:$10,000
The major goal of this study is to quantify levels of IL12 and IL23 in sera samples frompatients with Takayasu arteritis to determine which cytokine plays a critical role in
Takayasu arteritis and to analyze how variants in IL12B region contribute to basics in thisdisease.
Completed2016-2017

Investigation of gut microbiota in patients with Takayasu arteritis
The Cardiovascular Research Fund, Tokyo, Japan
Role:PI
Annual Direct Cost:$20,000
The major goal of this study is to analyze gut microbiota in patients with Takayasu
arteritis and show similarities of microbiota to patients with Inflammatory Bowel Diseaseespecially ulcerative colitis which frequently develops with Takayasu arteritis.
Current
FY2016-2017

Integrative omics analysis for Takayasu arteritis
Grant-in-Aid for Young Scientists (A) from The Ministry of Education, Culture, Sports,
Science and Technology/ JSPS KAKENHI Grant Number JP16H06251
Role: PI
Annual Direct Cost: $100,000
The major goal of this study is to clarify pathophysiology underlying rare autoimmune
diseases by mainly genetic studies and to identify critical molecules and pathways of thediseases to develop novel therapeutic strategy.

FY2016-2017

Why do patients with rheumatoid arthritis rarely develop DIP synovitis?
Grant-in-Aid for Challenging Exploratory Research from The Ministry of Education,
Culture, Sports, Science and Technology/ JSPS KAKENHI Grant Number JP16K15513
Role: PI
Annual Direct Cost: $17,000
The major goal of this study is to detect a mechanism underlying rheumatoid arthritis
which determines distribution of joint synovitis in rheumatoid arthritis.

FY2017-2018

Clarifying genetic similarities and differences between Takayasu arteritis and giant cellarteritis.
A Sakakibara Memorial Research Grant from The Japan Research Promotion Society for
Cardiovascular Diseases
Role: PI
Annual Direct Cost: $10,000
The major goal of this study is to analyze genetic characteristics of giant cell arteritis andcompare genetic components between Takayasu arteritis and giant cell arteritis.

Invited Presentations
2011 Sep 15‘Identification and functional analyses of susceptibility genes to rheumatoid arthritis’

Annual Congress of The Japan Society for Clinical Immunology (Tokyo, Japan)
2013 July 2‘How much do genetic component determine rheumatoid arthritis? –disease onset and its

disease phenotype’
The 34th Annual Meeting of the Japanese Society of Inflammation and Regeneration(Kyoto, Japan)
2013 Sep 28 ‘How much do genetic component determine rheumatoid arthritis? –disease onset and its
disease phenotype’
Kyoto Rheumatoid Arthritis Network Forum (Kyoto, Japan)
2013 Nov 16‘Combination of HLA-class I and II alleles confer exponential increase in the risk forantithyroid drug-induced agranulocytosis.’
The 56th Annual Congress of The Japan Society for Thyroid Disease (Wakayama, Japan)
2014 July 17 ‘Disease and phenotype-related HLA alleles and amino acids’
Keiji Immunity Hematology Seminar (Kyoto Japan)
2014 Oct 30 ‘HLA region and HLA amino acids related to diseases and phenotypes in autoimmune diseases’
Keiji Immunity Hematology Seminar (Kyoto Japan)
2016 Sep 22 ‘Clarification of pathophysiology and identification of treatment target of Takayasu arteritis bygenetic studies.’Awardee Ceremony for Young Investigator Okamoto Award (Tokyo, Japan)
2017 Sep 16 ‘HLA-B position 9 is associated with a specific rheumatoid arthritis subset defined by
non-canonical serologies’
The 16th Yotsuya Seminar for Rheumatic and connective tissue diseases (Tokyo, Japan)
2017 Oct 13 ‘Clarification of pathophysiology in rare autoimmune diseases through genetic approach’
JCR Basic Research Conference (Tokyo, Japan)
2017 Nov 17 ‘Clarification of pathophysiology in rare autoimmune diseases and development of newtreatment through genetic approach’
Awardee Ceremony for JSHG (Japan Society of Human Genetics) Young Investigator Award (Kobe, Japan)
Presentations (as presenter only)
2007 Apr 26‘Aeromonas hydrophila bacteremia after rituximab treatment in a patient with refractory

systemic lupus erythematosus’
The 51st Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Tokyo,
Japan) Oral presentation
2008 Apr 22‘Association between polymorphisms of TRAF1/C5 and rheumatoid arthritis in a Japanese

population’The 52nd Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology(Sapporo, Japan)
2008 Sep 20‘Association between HLA-DRB1 alleles and anti-CCP antibody in Japanese patients withrheumatoid arthritis’
Hiei RA forum (Kyoto, Japan) Oral presentation2009 Jun 11‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’European League Against Rheumatism (EULAR) Congress 2009 (Copenhagen, Denmark) Oral presentation

2009 Sep 26‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’
Annual Congress of The Japan Society of Human Genentics (Tokyo, Japan) Oral presentation2009 Nov 1‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’Kyoto University Global COE International symposium and retreat (Awaji, Japan) Oral presentation2010 Aug 25‘A genome-wide association study identifies myelin basic protein as a susceptibility gene torheumatoid arthritis in a Japanese population’
14th International Congress of Immunology (Kobe, Japan)
2011 May 27‘A HAPLOTYPE OF THE HUMAN AIRE GENE IS ASSOCIATED WITH THE RISK FOR

RHEUMATOID ARTHRITIS IN JAPANESE POPULATION’
European League Against Rheumatism (EULAR) Congress 2011 (London, UK) Oral presentation2011 Sep 9‘Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale

analysis for four years in Japanese’
Kyoto University Global COE International symposium and retreat (Awaji, Japan)
2011 Sep 15‘A Large-Scale Association Study Identified Multiple HLA-DRB1 Alleles Associated with

Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis in Japanese’
The 39th Annual Meeting of the Japan Society for Clinical Immunology (Tokyo, Japan)
2011 Nov 6‘A Large-Scale Association Study Identified Multiple HLA-DRB1 Alleles Associated with

Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis in Japanese’
Annual Congress of American College of Rheumatology (Chicago, USA)2011 Nov 28‘Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale

analysis for four years in Japanese’2011 Annual Meeting of the Japanese Society for Immunology (Chiba, Japan)
2012 Jun 9‘ACPA-NEGATIVE RHEUMATOID ARTHRITIS CONSISTS OF TWO GENETICALLYDISTINCT SUBSETS BASED ON RF POSITIVITY’
European League Against Rheumatism (EULAR) Congress 2012 (Berlin, Germany) Selected for one of theofficial poster tours
2012 Oct 25‘HLA region conferring levels of anti-nuclear antibody in a Japanese population’The 57th Annual Meeting of the Japan Society of Human Genentics (Tokyo, Japan) Oral presentation2012 Dec 6‘Three groups of joint synovitis in rheumatoid arthritis -analysis in KRAMA database-’2012 Annual Meeting of the Japanese Society for Immunology (Makuhari Messe, Chiba, Japan)
2013 Apr 18‘Prevalence of anti-nuclear antibody and impacts of age and sex on the antibody levels in a

Japanese population -the Nagahama study.’
The 57th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Kyoto,
Japan) Oral presentation2013 Apr 20‘Three susceptibility amino acids to Takayasu arteritis in HLA-B protein.’

The 57th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Kyoto,
Japan) Oral presentation2013 Jun 13‘A NATIONWIDE STUDY OF SYSTEMIC LUPUS ERYTHEMATOSUS IN JAPANESEIDENTIFIED SUBGROUPS OF PATIENTS WITH CLEAR SIGNS/CLINICAL MARKER PATTERNS AND
FOUND THAT PARTICULAR SIGNS/CLINICAL MARKERS ARE ASSOCIATED WITH AGE AND/ORSEX’European League Against Rheumatism (EULAR) Congress 2013 (Madrid, Spain)2013 Oct 25‘Two novel susceptibility loci to Takayasu arteritis and synergistic role of the IL12B and

HLA-B regions in a Japanese population.’
ASHG (American Society of Human Genetics) 2013 Annual Meeting (Boston, USA)
2013 Nov 23‘Four polymorphisms in HLA-class I and II confer exponential increase in the risk foranti-thyroid durg-induced agranulocytosis’
The 58th Annual Meeting of the Japan Society of Human Genentics (Sendai, Japan) Oral presentation2013 Nov 28‘Two novel susceptibility loci to Takayasu arteritis and synergistic role of the IL12B and

HLA-B regions in a Japanese population.’
The 41st Annual Meeting of the Japan Society for Clinical Immunology (Shimonoseki, Japan) Oralpresentation2014 Apr 4 ‘Heterogeneous characteristics of staining patterns among ANA’

16th Asia Pacific League of Associations for Rheumatology Congress (APLAR) (Cebu, Philippine) Oralpresentation2014 Apr 25 ‘The limited effects of smoking and shared epitope on the production of ACPA and RF in a
Japanese adult population: The Nagahama Study’
The 58th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Tokyo,
Japan)
2014 June 12 ‘ANTI-CITRULLINATED PEPTIDE/PROTEIN ANTIBODY (ACPA)-NEGATIVE RA SHARESLARGE PROPORTION OF SUSCEPTIBILITY GENES WITH ACPA-POSITIVE RA.’
European League Against Rheumatism (EULAR) Congress 2014 (Paris, France)2014 Nov 16 ‘Takayasu Arteritis and Ulcerative Colitis –High Concurrence Ratio and Genetic Overlap’
Annual Congress of American College of Rheumatology (Boston, USA)2014 Nov 22 ‘Ulcerative colitis is a major complication of Takayasu arteritis sharing genetic components
especially HLA-B*52:01’
The 59th Annual Meeting of the Japan Society of Human Genentics (Tokyo, Japan) Oral presentation
2015 Nov 9 ‘Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a
Dose-Dependent Manner’
Annual Congress of American College of Rheumatology (San Francisco, USA)2016 Jun 10 ‘FCGR2B AND MULTIPLE HLA LOCI ARE ASSOCIATED WITH SUSCEPTIBILITY TO
IGG4-RELATED DISEASE.’
European League Against Rheumatism (EULAR) Congress 2016 (London, United Kingdom) Oralpresentation
2016 Sep 28 ‘Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to rheumatoid
arthritis in the Japanese population’
Asia Pacific League Against Rheumatism (APLAR) Congress 2016 (China, Shanghai) Oral presentation
2016 Oct 19 ‘Specific rheumatoid arthritis antibody subphenotypes are associated with unique HLA-DRB1
residues at position 11’
ASHG (American Society of Human Genetics) 2016 Annual Meeting (Vancouver, Canada)
2016 Nov 16 ‘Specific Antibody Subphenotypes in Rheumatoid Arthritis Are Associated with Unique
HLA-DRB1 Residues at Position 11’
Annual Congress of American College of Rheumatology (Washington DC, USA) Oral presentation2017 Feb 15 ‘Genome-wide association study revealed multiple associated loci with IgG4-related disease’
Third International Symposium on IgG4-RD and Fibrosis (Hawaii, USA) Oral presentation2017 Jun 15‘TRANS-ETHNIC META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIESIDENTIFIES GSDMA AND PRDM1 AS SUSCEPTIBILITY GENES TO SYSTEMIC SCLEROSIS.’
European League Against Rheumatism (EULAR) Congress 2017 (Madrid, Spain) Selected for one of theofficial poster tours

PatentUSE OF MYELIN BASIC PROTEIN AS A NOVEL GENETIC FACTOR FOR RHEUMATOID ARTHRITISWO Patent 2,012,144,512

Bibliography (* as corresponding author, ** as equal contributor)
Original Research
1. Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, Hashimoto H, Tokano Y, Mimori T, Terao C,
Matsuda F, Kuno T, Kumagai S.
Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a
Japanese population.
Mod Rheumatol. 2009;19(4):401-6.
2. Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K,
Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S,
Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Nat Genet. 2010;42(6):515-9.
3. Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo S, Takasugi K,
Tohma S, Matsuo K, Tajima K, Yukawa N, Kawabata D, Nojima T, Fujii T, Yamada R, Saji H, Matsuda F,
Mimori T.
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only
bone-erosive ACPA-negative rheumatoid arthritis.
Rheumatology (Oxford). 2010;49(12):2298-304.
4. Terao C, Yamada R, Ohmura K, Takahashi M, Kawaguchi T, Kochi Y; Human Disease Genomics
Working Group; RA Clinical and Genetic Study Consortium, Okada Y, Nakamura Y, Yamamoto K, MelchersI, Lathrop M, Mimori T, Matsuda F.
The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid
arthritis in Japanese population.
Hum Mol Genet. 2011;20(13):2680-5.
5. Takeda N, Nojima T, Terao C, Yukawa N, Kawabata D, Ohmura K, Usui T, Fujii T, Ito Y, Iinuma Y,
Mimori T.
Interferon-gamma release assay for diagnosing Mycobacterium tuberculosis infections in patients withsystemic lupus erythematosus.
Lupus. 2011;20(8):792-800.
6. Meziani R, Yamada R, Takahashi M, Ohigashi K, Morinobu A, Terao C, Hiratani H, Ohmura K,
Yamaguchi M, Nomura T, Vasilescu A, Kokubo M, Renault V, Hirosawa K, Ratanajaraya C, Heath S,
Mimori T, Sakaguchi S, Lathrop M, Melchers I, Kumagai S, Matsuda F.
A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor inJapanese and European populations.
Mod Rheumatol. 2012;22(1):52-8.
7. Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto N; HumanDisease Genomics Working Group; Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium,
Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M, Mimori T, Yamada R, Matsuda
F.
Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis-a genome-wide study combinedwith immunological analyses.
PLoS One. 2011;6(6):e20457.
8. Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A, Honjo S,
Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H,
Matsuda F, Mimori T.
A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative
rheumatoid arthritis in Japanese subjects.
Ann Rheum Dis. 2011;70(12):2134-9.
9. Terao C*, Ohmura K, Yamamoto K, Yukawa N, Kawabata D, Nojima T, Fujii T, Mimori T.
Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale, 4-year analysis inJapanese.
Mod Rheumatol. 2012;22(3):426-30.
10. Terao C*, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A, Momohara S,
Yamanaka H, Matsuda F, Mimori T.
Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis: no strong genetic
impact of shared epitope to ACPA levels after stratification of HLA-DRB1*09:01.
Ann Rheum Dis. 2012;71(6):1095-7.
11. Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T,
Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M,
Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda
T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T,
Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K.
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus
Eyrthematosus in Japanese.
PLoS Genet. 2012;8(1):e1002455.
12. Okada Y, Terao C**, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA,
Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani
S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K,
Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington
J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N,
Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Nat Genet. 2012;44(5):511-6.

13. Terao C*, Ohmura K, Ikari K, Kochi Y, Maruya E, Katayama M, Yurugi K, Shimada K, Murasawa A,
Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R,
Saji H, Matsuda F, Mimori T.
ACPA-Negative RA Consists of Two Genetically Distinct Subsets Based on RF Positivity in Japanese.
PLoS One. 2012;7(7):e40067.
14. Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, Tsunoda T, Takahashi A, Kubo M, Taniguchi
A, Matsuda F, Ohmura K, Momohara S, Mimori T, Yamanaka H, Kamatani N, Yamada R, Nakamura Y,
Yamamoto K.
Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associatedwith Rheumatoid Arthritis in Japanese.
PLoS Genet. 2012 Sep;8(9):e1002949.
15. Terao C*, Ohmura K, Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota
Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N,
Matsuda F, Mimori T.
PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population.
Arthritis Rheum. 2013 Feb;65(2):472-80.
16. Terao C*, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji
H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T.
Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis - Analysis Using More than 17,000
Assessments in the KURAMA Database.
PLoS One. 2013;8(3):e59341.
17. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K,
Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F,
Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet
ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar
HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland
LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK,
Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM.
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response
to Etanercept Therapy in Rheumatoid Arthritis.
PLoS Genet. 2013 Mar;9(3):e1003394.
18. Tabara Y, Takahashi Y, Setoh K, Muro S, Kawaguchi T, Terao C, Kosugi S, Sekine A, Yamada R,
Mishima M, Nakayama T, Matsuda F; on behalf of the Nagahama Study Group.
Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers
confirmed by urinary cotinine levels: The Nagahama Study.
Int J Cardiol. 2013 Apr 8. doi:pii: S0167-5273(13)00447-6.

19. Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S,
Sekine A, Miki T, Nakayama T, Matsuda F; Nagahama Study Group.
Association of Longer QT Interval With Arterial Waveform and Lower Pulse Pressure Amplification: The
Nagahama Study.
Am J Hypertens. 2013;26(8):973-80.
20. Plenge RM, Greenberg JD, Mangravite LM, Derry JM, Stahl EA, Coenen MJ, Barton A, Padyukov L,
Klareskog L, Gregersen PK, Mariette X, Moreland LW, Bridges SL Jr, de Vries N, Huizinga TW, Guchelaar
HJ; International Rheumatoid Arthritis Consortium (INTERACT), Friend SH, Stolovitzky G.
Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.
Nat Genet. 2013;45(5):468-9. (Correspondence)
21. Katayama M, Ohmura K, Yukawa N, Terao C, Hashimoto M, Yoshifuji H, Kawabata D, Fujii T, Iwakura
Y, Mimori T.
Neutrophils are essential as a source of IL-17 in the effector phase of arthritis.
PLoS One. 2013;8(5):e62231.
22. Terao C*, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T,
Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y,
Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai
R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.
Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions
in a Japanese Population.
Am J Hum Genet. 2013;93(2):289-97.
23. Terao C*, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura
A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F.
Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein.
Rheumatology (Oxford). 2013;52(10):1769-74.
24. Terao C, Bayoumi N, McKenzie CA, Zelenika D, Muro S, Mishima M; The Nagahama Cohort ResearchGroup, Connell JM, Vickers MA, Lathrop GM, Farrall M, Matsuda F, Keavney BD.
Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in
the ABO Blood Group Locus.
Ann Hum Genet. 2013 Nov;77(6):465-71..
25. Tanaka K, Terao C*, Ohmura K, Takahashi M, Nakashima R, Imura Y, Yoshifuji H, Yukawa N, Usui T,
Fujii T, Mimori T, Matsuda F.
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patientswith connective tissue diseases.
J Hum Genet. 2014 Feb;59(2):107-9.

26. Terao C*, Hashimoto M, Furu M, Nakabo S, Ohmura K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H,
Matsuda F, Ito H, Fujii T, Mimori T.
Inverse association between air pressure and rheumatoid arthritis synovitis
PLoS One. 2014 Jan 15;9(1):e85376.
27. Tabara Y, Muro S, Takahashi Y, Setoh K, Kawaguchi T, Terao C, Kosugi S, Sekine A, Yamada R,
Nakayama T, Mishima M, Matsuda F.
Airflow limitation in smokers is associated with arterial stiffness: The Nagahama Study.
Atherosclerosis 2014;232(1):59-64.
28. Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR,
Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas
DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta
N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van RielPL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Louis Bridges Jr S, Zhernakova A,
Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez
L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; the RACI consortium; theGARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW,
Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK,
Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T,
Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.
Nature. 2014 Feb 20;506(7488):376-381.
29. Furu M, Hashimoto M, Ito H, Fujii T, Terao C, Yamakawa N, Yoshitomi H, Ogino H, Ishikawa M,
Matsuda S, Mimori T.
Discordance and accordance between patient’s and physician’s assessments in rheumatoid arthritis
Scand J Rheumatol. 2014;43(4):291-5.
30. Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nishikori M, Nakashima R, Imura Y, Yukawa N,
Yoshifuji H, Ohmura K, Fujii T, Kitano T, Kondo T, Yurugi K, Miura Y, Maekawa T, Saji H, Takaori-Kondo
A, Matsuda F, Haga H, Mimori T.
A Clinical, Pathological and Genetic Characterization of Methotrexate-Associated Lymphoproliferative
DisordersJ Rheumatol. 2014 Feb;41(2):293-9.
31. Hashimoto M, Fujii T, Hamaguchi M, Furu M, Ito H, Terao C, Yamamoto K, Yamamoto W, Matsuo T,
Mori M, Ohmura K, Kawabata H, Mimori T.
Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis.
PLoS One. 2014 May 30;9(5):e98202.

32. Terao C, Terada N, Matsuo K, Kawaguchi T, Yoshimura K, Hayashi N, Shimizu M, Soga N, Takahashi
M; Nagahama Cohort Study Group, Kotoura Y, Yamada R, Ogawa O, Matsuda F.
A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population.
J Med Genet. 2014 Aug;51(8):530-6.
33. Terao C*, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A,
Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R, Matsuda F, Mimori T; on behalf of the
Nagahama Study Group.
The effects of smoking and shared epitope on the production of ACPA and RF in a Japanese adult
population: The Nagahama Study.
Arthritis Care Res (Hoboken). 2014 Dec;66(12):1818-27.
34. Terao C, Yamada R, Mimori T, Yamamoto K, Sumida T.
A nationwide study of SLE in Japanese identified subgroups of patients with clear signs patterns andassociations between signs and age or sex.
Lupus, 2014 Nov;23(13):1435-42.
35. Terao C*, Ohmura K, Yamada R, Kawaguchi T, Shimizu M, Tabara Y, Takahashi M, Setoh K, Nakayama
T, Kosugi S, Sekine A, Matsuda F, Mimori T; on behalf of the Nagahama Study Group.
An association between anti-nuclear antibody and HLA class II locus and heterogeneous characteristics ofstaining patterns: The Nagahama Study.
Arthritis Rheumatol. 2014 Dec;66(12):3395-403.
36. Tabara Y, Takahashi Y, Kawaguchi T, Setoh K, Terao C, Yamada R, Kosugi S, Sekine A, Nakayama T,
Matsuda F; on behalf of the Nagahama Study Group.
Association of Serum-Free Fatty Acid Level With Reduced Reflection Pressure Wave Magnitude andCentral Blood Pressure: The Nagahama Study.
Hypertension. 2014 Dec;64(6):1212-8.
37. Kumagai K, Tabara Y, Yamashiro K, Miyake M, Akagi-Kurashige Y, Oishi M, Yoshikawa M, Kimura Y,
Tsujikawa A, Takahashi Y, Setoh K, Kawaguchi T, Terao C, Yamada R, Kosugi S, Sekine A, Nakayama T,
Matsuda F, Yoshimura N; the Nagahama Study group.
Central blood pressure relates more strongly to retinal arteriolar narrowing than brachial blood pressure: theNagahama Study.
J Hypertens. 2015 Feb;33(2):323-9.
38. Terao C*, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H, Fujii T, Ohmura K,
Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F.
Main Contribution of DRB1*04:05 Among the Shared Epitope Alleles and Involvement of DRB1 Amino
Acid Position 57 in Association With Joint Destruction in Anti-Citrullinated Protein Antibody-Positive
Rheumatoid Arthritis.
Arthritis Rheumatol. 2015 Jul;67(7):1744-50.

39．Terao C*, Asai K, Hashimoto M, Yamazaki T, Ohmura K, Yamaguchi A, Takahashi K, Takei N, Ishii T,
Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Fujii T, Yamada R, Mimori T,
Matsuda F, Bessho K; Nagahama Study Group.
Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy
population - The Nagahama study.
J Autoimmun. 2015 May;59:85-90.
40. Terao C*, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, Nakabo S, Yamamoto N, Suzuki T,
Iwamoto T, Yurugi K, Miura Y, Maekawa T, Takasugi K, Kubo M, Saji H, Taniguchi A, Momohara S,
Yamamoto K, Yamanaka H, Mimori T, Matsuda F.
An association between amino acid position 74 of HLA-DRB1 and anti-citrullinated protein antibody levels
in Japanese patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.
Arthritis Rheumatol. 2015 May;67(8):2038-45.
41. Ito A, Shimada H, Ishikawa K, Takeo N, Hatano Y, Katagiri K, Kohno K, Araki Y, Terao T, Kojima H,
Terao C, Eshima N, Fujiwara S.
Association between HLA-DRB1*0405, -DQB1*0401 and -DQA1*0303 alleles and lamotrigine-induced
cutaneous adverse drug reactions. A pilot case-control study from Japan.
J Affect Disord. 2015 Mar 20;179:47-50.
42. Hashimoto M, Yamazaki T, Hamaguchi M, Morimoto T, Yamori M, Asai K, Isobe Y, Furu M, Ito H, Fujii
T, Terao C, Mori M, Matsuo T, Yoshitomi H, Yamamoto K, Yamamoto W, Bessho K, Mimori T.
Periodontitis and Porphyromonas gingivalis in Preclinical Stage of Arthritis Patients.
PLoS One. 2015 Apr 7;10(4):e0122121.
43. Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, Nishina N, Suzuki A, Myouzen K,
Kawaguchi T, Takahashi M, Takasugi K, Murasawa A, Mizuki S, Iwahashi M, Funahashi K, Natsumeda M,
Furu M, Hashimoto M, Ito H, Fujii T, Ezawa K, Matsubara T, Takeuchi T, Kubo M, Yamada R, Taniguchi A,
Yamanaka H, Momohara S, Yamamoto K, Mimori T, Matsuda F.
Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares large proportion of susceptibilityloci with ACPA-positive RA: -a meta-analysis of genome-wide association study in a Japanese population.
Arthritis Res Ther. 2015 Apr 18;17(1):104.
44. Terao C*, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura
N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H,
Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K,
Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F.
Takayasu arteritis and ulcerative colitis -high concurrence ratio and genetic overlap.
Arthritis Rheumatol. 2015 May;67(8):2226-2232.
45. Setoh K, Terao C*, Muro S, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A,Yamada R, Mishima M, Matsuda F.
Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.
Nat Commun. 2015 Jul 15;6:7754.
46. Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M,
Hamamoto Y, Mimori T, Akiyama H, Matsuda S.
Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment inpatients with rheumatoid arthritis.
Osteoporos Int. 2016 Feb;27(2):691-701.
47. Terao C*, Yamakawa N, Yano K, Markusse IM, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fujii T,
Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri
S, Allaart CF, Yamanaka H, Mimori T, Matsuda F.
Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis.
Arthritis Rheumatol. 2015 Dec;67(12):3113-23.
48. Terao C*, Yoshifuji H, Nakajima T, Yukawa N, Matsuda F, Mimori T.
Ustekinumab as a therapeutic option for Takayasu arteritis: from genetic findings to clinical application.
Scand J Rheumatol. 2016 Jan:45 (1), 80-82.
49. Hamamoto Y, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M,
Iwata T, Mimori T, Matsuda S.
Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid
Arthritis - A Cross-Sectional Cohort Study.
PLoS One. 2015 Aug 28;10(8):e0136611.
50. Tabara Y, Takahashi Y, Kumagai K, Setoh K, Kawaguchi T, Takahashi M, Muraoka Y, Tsujikawa A,
Gotoh N, Terao C, Yamada R, Kosugi S, Sekine A, Yoshimura N, Nakayama T, Matsuda F; Nagahama study
group.
Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with bloodpressure level: the Nagahama study.
J Hypertens. 2015 Dec;33(12):2407-13.
51. Puig M, Castellano D, Pantano L, Giner-Delgado C, Izquierdo D, Gayà-Vidal M, Lucas-Lledó JI, Esko T,
Terao C, Matsuda F, Cáceres M.
Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene andCreates a Fusion Transcript.
PLoS Genet. 2015 Oct 1;11(10):e1005495.
52. Iguchi-Hashimoto M, Hashimoto M, Fujii T, Hamaguchi M, Furu M, Ishikawa M, Ito H, Yamakawa N,
Terao C, Yamamoto K, Yamamoto W, Ohmura K, Mimori T.
The association between serious infection and disease outcome in patients with rheumatoid arthritis.

Clin Rheumatol. 2016 Jan;35(1):213-8.
53. Tabara Y, Takahashi Y, Setoh K, Kawaguchi T, Gotoh N, Terao C, Yamada R, Kosugi S, Sekine A,
Nakayama T, Matsuda F; Nagahama Study group.
Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a
general population: The Nagahama Study.
Metabolism. 2016 Jan;65(1):66-72.
54. Terao C*, Ikari K, Nakayamada S, Takahashi Y, Yamada R, Ohmura K, Hashimoto M, Furu M, Ito H,
Fujii T, Yoshida S, Saito K, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F.
A twin study of rheumatoid arthritis in the Japanese population.
Mod Rheumatol. 2016 Sep;26(5):685-9.
55. Terao C*, Yoshifuji H, Yamano Y, Kojima H, Yurugi K, Miura Y, Maekawa T, Handa H, Ohmura K, Saji
H, Mimori T, Matsuda F.
Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic
characteristics from other rheumatic diseases
Rheumatology (Oxford). 2016 Sep;55(9):1686-92.
56. Muro S, Tabara Y, Matsumoto H, Setoh K, Kawaguchi T, Takahashi M, Ito I, Ito Y, Murase K, Terao C,
Kosugi S, Yamada R, Sekine A, Nakayama T, Chin K, Mishima M, Matsuda F; Nagahama Study Group.
Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic
Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study.
Medicine (Baltimore). 2016 Apr;95(15):e3371.
57. Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M,
Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi
A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y,
Yamamoto K.
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
Am J Hum Genet. 2016 Aug 4;99(2):366-74.
58. van Wesemael TJ, Ajeganova S, Humphreys J, Terao C, Muhammad A, Symmons DP, MacGregor AJ,
Hafström I, Trouw LA, van der Helm-van Mil AH, Huizinga TW, Mimori T, Toes RE, Matsuda F, Svensson
B, Verstappen SM, van der Woude D.
Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather
than with anti-citrullinated protein antibodies per se: a multicenter cohort study.
Arthritis Res Ther. 2016 Dec 1;18(1):285.
59. Yaku A, Hashimoto M, Furu M, Ito H, Yamakawa N, Yamamoto W, Fujii T, Matsuda F, Mimori T, Terao
C.*
Relationship between handedness and joint involvement in rheumatoid arthritis.

Sci Rep. 2016 Dec 15;6:39180.
60. Hiwa R, Ohmura K, Nakabo S, Terao C, Murakami K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H,
Hashimoto M, Furu M, Ito H, Fujii T, Mimori T.
Only rheumatoid factor-positive subset of anti-citrullinated peptide/protein antibody-negative rheumatoid
arthritis may seroconvert to anti-citrullinated peptide/protein antibody-positive.
Int J Rheum Dis. 2017 Feb 15. doi: 10.1111/1756-185X.13000. [Epub ahead of print]
61. Terao C*, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M,
Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P,
Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A,
Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto
D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen
P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y.
Trans-ethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
Ann Rheum Dis. 2017 (in press)
62. Higasa K, Ogawa A, Terao C, Shimizu M, Kosugi S, Yamada R, Date H, Matsubara H, Matsuda F.
A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial
hypertension.
BMC Pulm Med. 2017 Apr 7;17(1):57
63. Hiwa R, Ohmura K, Arase N, Jin H, Hirayasu K, Kohyama M, Suenaga T, Saito F, Terao C, Atsumi T,
Iwatani H, Mimori T, Arase H.
Myeloperoxidase/HLA class II complexes recognized by autoantibodies in microscopic polyangiitis.
Arthritis Rheumatol. 2017 Jun 2. doi: 10.1002/art.40170.
64. Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu
M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB.
Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages andSuppresses Osteoclastogenesis.
Immunity. 2017 Jul 18;47(1):66-79.e5.
65. Tsuji H, Yano K, Furu M, Yamakawa N, Ikari K, Hashimoto M, Ito H, Fujii T, Yamamoto W, Ohmura K,
Taniguchi A, Momohara S, Matsuda F, Allaart CF, Yamanaka H, Mimori T, Terao C*.
Time-averaged disease activity fits better joint destruction in rheumatoid arthritis.
Sci Rep. 2017 Jul 19;7(1):5856.

66. Kuramoto N, Ohmura K, Ikari K, Yano K, Furu M, Yamakawa N, Hashimoto M, Ito H, Fujii T,
Murakami K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Taniguchi A, Momohara S, Yamanaka H,
Matsuda F, Mimori T, Terao C*.

Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may
characterize a distinct subset in rheumatoid arthritis.
Sci Rep. 2017 Jul 31;7(1):6911.
67. Nakajima T, Yoshifuji H, Shimizu M, Kitagori K, Murakami K, Nakashima R, Imura Y, Tanaka M,
Ohmura K, Matsuda F, Terao C, Mimori T.
A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis
through IL-12p40 and IL-12p70 production.
Arthritis Res Ther. 2017 Sep 6;19(1):197.
68. Hiwa R, Ikari K, Ohmura K, Nakabo S, Matsuo K, Saji H, Yurugi K, Miura Y, Maekawa T, Taniguchi A,
Yamanaka H, Matsuda F, Mimori T, Terao C*.
HLA-DRB1 analysis utilizing consecutive data of rheumatoid factor (RF) identified a genetically uniquesubset among rheumatoid arthritis and distinct genetic background of RF levels from anti-cyclic citrullinatedpeptide antibodies
J Rheum. 2017 (in press)
69. Terao C*, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, Matsuo K, Taniguchi A, Kubo M,
Raychaudhuri S, Yamamoto K, Yamanaka H, Kamatani Y, Mimori T, Matsuda F.
Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid
arthritis and ACPA levels in Japanese population.
J Med Genet. 2017 Oct 12. pii: jmedgenet-2017-104779. doi: 10.1136/jmedgenet-2017-104779. [Epubahead of print]

Review
1. Ohmura K, Terao C, Mimori T.
Recent advances on the genetics of rheumatoid arthritis: current topics and the future
Inflammation and Regeneration 2012, 32 (3), 90-98
2. Terao C*, Yoshifuji H, Mimori T.
Recent advances in Takayasu arteritis.
Int J Rheum Dis. 2014,17(3):238-47
3. Terao C*
Genetic contribution to susceptibility and disease phenotype in rheumatoid arthritis.
Inflammation and Regeneration 2014, 34 (2), 71-77
4. Terao C*
History of Takayasu arteritis and Dr. Mikito Takayasu.
Int J Rheum Dis. 2014 Nov;17(8):931-5.
5. Terao C*
Revisited HLA and non-HLA genetics of Takayasu arteritis—where are we?
J Hum Genet. 2016 Jan;61(1):27-32.
6. Terao C, Raychaudhuri S, Gregersen PK.
Recent Advances in Defining the Genetic Basis of Rheumatoid Arthritis.
Annu Rev Genomics Hum Genet. 2016 Aug 31;17:273-301.
Book
SYSTEMIC VASCULITIDES: CURRENT STATUS AND FUTURE PERSPECTIVES.
2016(in press). Springer