Consolidated Financial Result Briefing
for the Six Months ended September 30, 2022

CYBERDYNE, Inc.
November 14, 2022

Consolidated

nancial results (IFRS)
Year-on-year comparison for the six months ended September 30, 2022

Revenue: 1,542M (+87% YoY)
Operating profit: ¥-442M (Improved 39M YoY)
Final profit: ¥268M (Improved by 696M YoY)
(Unit: Millions of yen)

FY2021

FY2022

Q1+Q2

Q1+Q2

825
(619)

1,542
(989)

Revenue(Gross profit)

+/-

+/-%

+717 *1(+370)+86.9％ *1

-481

-442

Rental +148M (HAL outside Japan, sleeping app)
Sales
+49M (Acoustic X outside Japan)
Service +521M (Treatment service by RISE Group in USA)(+59.8%)*２ Increase in SG&A (381M) (YoY)*２
Operating profit*1 Increase in revenue（717M）（YoY）

+39

ー

+763

ー

SG&A expenses of consolidated subsidiary acquired
through M&A +410M (PMI cost following M&A)

*３ *４

-389

Profit before tax

373*３ Exchange gain 154M (in nance income)*４ Gains related to investment securities 638M
（Net）

Profit attributable toowner of the parent

-428

268

+696

ー

Finance income (gain on valuation) +519M
Gains related to CEJ +118M
Ref) revenue related to investment securities in the
rst half of the previous scal year 65M (net)

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Consolidated nancial results (IFRS)
Performance trends【Q2 results】Revenue +78% pro t 27M (in black)
Consolidated statementof profit or loss

Revenue

FY2021

FY2022Q2

Q1Quarter on Quarter

Q2

Q1-Q2

+/-

(Unit : Millions of yen)

Year on Year

+/-%

+/-

+/-%

445

751

791

1,542

+39

+5.2%

+346

+77.7%

103

261

292

553

+31

+11.8%+189+183.1%

342

490

499

989

+9

+1.7%

+157

+45.9%

R&D expenses

162

151

182

333

+31

+20.4%+19+12.0%

Other SG&A

390

568

594

1,162

+25

+4.4%

+203

+52.2%

Other income/expenses

12

51

12

63

-38

-75.5%+0+2.3%

Operating profit

-198

-178

-264

-442

-86

-

-66

-

Finance income/expense

21

541

134

675

-408

-75.3%+113+539.7%

Other

53

9

132

140

+123

+1436.9%+79+148.0%

Profit before tax

-124

372

1

373

-370

-

+126

-

Profit attributable toowner of the parent

-152

241

27

268

-215

-89.0%+178-

Cost of sales
Gross profit

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Consolidated nancial results (IFRS)
by types of transaction
Increase service sales by acquiring treatment service locations in the U.S.
1,542

(Millions of yen)

Services
639

825

83

（+439%）

Sales

83

119

+49M
（+141%）

Sales revenue from Acoustic X* sold outside Japan, etc.
*Acoustic X：Photoacoustic Imaging device using LED Light array

34

672

820

Rental+148M

Increase of HAL rented outside Japan Revenue fromsleeping app, etc.

（+22%）
Service: Revenue from service at a point of time
Sales: Revenue from sales at a point of time

FY2021 Q1+Q2
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+521M

Income from treatment services of RISE Group in the U.S., etc.

FY2022 Q1+Q2

Rental and maintenance: revenue over time6

Number of operating units
Growth of Medical Lower Limb Type (overseas) and Single Joint Type (domestic) rentals(Unit: Millions of yen)
Product classification

For Hospitals(improving function)

HAL Lower Limb Type(Medical)
HAL Lower Limb Type
(Non-medical)

FY2021
Q1+Q2

FY2022
Q1+Q2(Ratio)269

328 *１

40%

94

90

11%
*２

HAL Single Joint Type

60

90

11%

Care support
and well-being

HAL Lumbar Type

131

118

14%

Labor Support

HAL Lumbar Type

55

35

4%

Cleaning/disinfection/transportation robot

27

26

3%

Other

37

134 *３

16%

Total

672

820

100%

*１ HAL Lower Limb Type (Medical)
The main factors of the increase in sales
were from APAC and Europe*２ HAL Single Joint TypeThe main factors of the increase in sales
were Japanese hospitals*３ Subscription fee from JUKUSUI
Sleeping app
Due to M&A in the previous scal yearfi

7Consolidated nancial results (IFRS)
by geographical region
Sigini cant increase of oversea sale (22% to 53% of total revenue)

Americas 1%
EMEA 9%APAC 11%• Significant increase in revenue due to the acquisition of treatment sites in the U.S.
• APAC and EMEA also increased sales by approx. 70%.

10 Million

76 Million

94 Million

522 Million

Americas 34%

Japan

Japan

78%
（645 Million）

FY2021 Q1+Q2
Americas: North, Central and South America
EMEA : Europe, the Middle East and Africa
APAC : Asia-Paci c * Revenue from Japan is stated separately

EMEA 8%APAC 11%127 Million

47%（726 Million）

167 Million

FY2022 Q1+Q2

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Ref) by geographical regions and type of transaction(Unit : Millions of yen)

FY2022 - Q1+Q2(FY2021 - Q1+Q2)

RentalSales

Service

Total

562

57

106

726

(526)

(32)

(87)

(645)

14

17

491

522

(10)

(0)

(0)

(10)

86

0

41

127

(44)

(0)

(31)

(76)

APAC

158

9

0

167

(93)

(1)

(0)

(94)

Total

820

83

639

1,542

(672)

(34)

(119)

(825)

Japan

Americas

EMEA

9Pro t Structure: Rebalancing Business Structure for Growth
Accelerate social implementation as an in-house service business

Aggressive expansion
5,000(Unit: Millions of yen)・Medical service for individuals (US)・Healthcare service for individuals (JP)

4,000
2,500
50%

*Utilize M&A

3,000

Reinforcement

1,500
39%

2,150

Services(Flow/BtoC)

1,875
268
14%

2,000

524
24%

・Rental to medical facilities in Japan
2,500
50%

1,607
86%

1,626
76%

・Rental to medical facilities (APAC・EU)

2,000
61%

1,000

Rental etc.
(Stock/BtoB)*Product sales are included in rentals, etc.

FY2020
ActualFY2021
ActualFY2022
Forecast

FY2023
Targetfi

10Outline of the business

CYBERDYNE, Inc.

11

Realization of Techno-peer Support Society,

Where human and technology lives together and supports each otherPromote innovation that “leaves no one behind”
Maintain and manage their health even in old age and exercise their long-cultivated abilities tothe fullest even if they have a disability due to a decline in physical functions caused by disease,accident, or aging, they can live with a higher degree of independence.

Brain
Brain

Technology
Technology as
the new partner

Peer

Society
1.0

Society
2.0

Society
3.0

Society
4.0

Society 5.0/5.1

Promote healthy lives of many people with technology・・・aging, burdening-care

Physical space

Cyber space

Cybernics Space→ Create “Cybernics Industry”, a new industry that follows Robot and IT Industry
12Cybernics Technology: Innovative core technology of Cybernics Industry*Cybernics:
New academic eld that fuses and combines
cross-disciplinary elds. It is centered aroundhumans, robots, and information systems, aswell as other elds.

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Integrated Cybernics System : Fusion of “Human” + “Cyber/Physical Space”
Realization of physical and informational interaction with 'people' to solve various issues in a super-aging society
Create a "Cybernics Industry" for people and society, focusing on medical care, welfare, daily life, workplace, and production
long-term care

Medicine

Cybernics Treatment

Vital Sensing

Promoting
Independence

Watch-overfor safety

Care
Support

Mobility
SupportLabor
SupportIntegrated
Cybernics System

Workplace

Daily life

Transportation
Production

Cleaning/sterilization
14

Main business model

For professional

For individuals(B to B)

(B to C)CYBERDYNE
Rental*1*2Service*1 Includes revenue fromsales and maintenances*2 Includes revenue from rental
15

C-Startup : Innovation ecosystem to create Cybernics Industry
University andresearch institutions

Cybernics Industry
bio/drug discovery

2020/12 listed

regenerative
medicine

2022/12 listed

Cutting-edge
technology

Med Tech

C-Startup

Big
Data

Technical advices
Financial support
Business support

IoH/IoTCYBERDYNE
Medical institutions,care facilities, companies,
allied partners

Start-ups andentrepreneurs

Robotics

AI

CEJ Fund (scale of 10 billion)

University, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the
21st century
Smart city council etc,.

2022.9.27 updated
16

Cybernics Medical Innovation BaseCreation of new treatment with Cybernics Treatment combined withregenerative medicine and drug discovery

Kingsky Front Tonomachi, Kawasaki
New base with a view to global expansion(Directly connected to Haneda Airport)

Tamagawa Sky Bridge(Opened March 2022)(Schedule)

Tokyo International
Airport (Haneda Airport)

Cybernics Medical Innovation Base
Building A

2022/3 Main building
completed2022/9 Additional interior workin progress
2023/1 Scheduled to start
occupancy
17

【Medical】Cybernics Treatment

CYBERDYNE, Inc.

18

【Medical】Cybernics Treatment (functional improvement/rehabilitation treatment)

Cybernics Treatment: Innovative method utilizing HAL for treating brain-nerve-musculoskeletal disorders

HAL Lumbar TypeHAL Single Joint Type

HAL Lower Limb Type19

Development pipeline
Target disease

Product
Development

Clinical Trial(Exploratory)

Clinical Trial(Validation)

Application/
examination

Approval

Marketing(public healthinsurance in Japan)(Post-marketingsurveillance)

Public healthinsurance

Neuromuscular
Disease(8 types of diseasesuch as ALS)

Spastic paraplegia

PublicHealthInsurance

Approved(Expanded)(HAM etc.)

Spinal Cord Injury

As of October 28, 2022
Status
Revision of insurance scheme
Planning for public health insurance(Germany, England)
Planning for public health insurance
Preparing for insurance application
Preparing application for expansion
Preparing application for expansion

Public medical
insurancecoverage forclinical trials

GermanPublic workers
Compensation
insurance

Considering clinical trial
Preparing trial for public healthinsurance (Germany)
Planning for public health insurance
Discussing with the authorities

StrokePlanning for public health insurance
Planning for public health insurance
Investigator-initiated clinical trial

Cerebral Palsy

Multiple Sclerosis
Conducting pilot research
Conducting pilot research

Parkinsons’DiseaseThe above situation encompasses HAL products (Lower Limb Type and Lumbar Type).
The Single Joint Type has already obtained medical device approval in Japan and the U.S. without limitation on target diseases.

20

Status of approvals by diseases and countries

承認

Signi cant progress in medical devices in the U.S., Europe, and Asia
【HAL for Medical Use Lower Limb Type】

As of October 28, 2022
Stroke

EMEA

APAC

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Neuromuscular disease*

Approved

Japan(Discussing the result of
the clinical trial)

Planning clinical trial(expand the approval for Medical HAL
to treat HTLV-1-related myelopathy
and hereditary spastic paraplegia)

USA

Approved

Approved

ApprovedEU

Approved

Approved

Approved

Saudi Arabia

Approved

Approved

Approved

TurkeyApproved

Approved

Approved

Malaysia

Approved

Approved

Approved

Indonesia
ThailandApproved
Approved

Approved
Approved

Taiwan(application in progress)

Singapore

Approved
Approved

Approved
Approved
Approved
Approved
Approved

Australia
CYBERDYNE, Inc.

Spinal Cord Injury(application in progress)

Approved
Approved*Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis,
Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophy

21

Oversea expansion of HAL
Progress
in US, EU and APAC despite
COVID を全国展開（全16箇所）
HALを使用したNeuro
HALFIT
Yellow indicates new introduction areas after After the outbreak of COVID-19
PolandConstance care

New installation after April 2021

*private insurance
coverage

Germany*Covered by Public workers
compensation insurance
and private insurance

EnglandMajor contract with
Hampshire County Council

Italy
Centro San Girolamo

FranceHospices Civils de Lyon

Seattle, Washington
SNI Swedish Medical Center

SerbiaPoliklinika Orto MD

Jacksonville, Florida
Brooks Cybernics Treatment Center

Expands to 3 facilities
Spain
BioCruces Bizkaia

TurkeyDiagenics

Switzerland

India
IBS Hospital

TaiwanCHC Group Hospital

California
Phillipines
RISE Physical Therapy (214 facilities in Metropolitan
facilities)
Area

Saudi Arabia
ALJ Hospital

KuwaitSingapore General HospitalThailandPiyavate Hospital

BrazilBrazilLarge distribution of HTLV-1associated myelopathy (HAM)
infected individuals

Malaysia
SOCSO Rehab Center
Operated in 9 facilities

Indonesia
Dr. Cipto Mangunkusumo
National Central Public Hospital
Australia
Established RoboFit

22®︎

CYBERDYNE, Inc.

Malaysia (1)Public Social Security System Accelerates Cybernics Treatment Penetration in Malaysia

98 HALs rented for a fee at
10 facilities in Malaysia
More locations to be added in the future

SOCSO (Malaysian Public Social Security Organization)
SOCSO has four functions: disability pension, survivor’s pension, medical
coverage and occupational injury coverage, and is compulsory for Malaysian
and foreign workers in Malaysia to join the program. It provides medical
compensation, disability compensation, funeral bene ts, child support andnursing care bene ts for illness or injury that occurs while commuting to andfrom work.

As of October 28 2022
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Malaysia (2)Largest medical complex in Southeast Asia “National Centre for Neuro-Robotics and Cybernics”

SOCSO constructs “National Neuro-Robotic and Cybernics Centre”
in the northern region of Malaysia
National Centre for Neuro-Robotics and Cybernics
It is being built in Bandar Meru Raya, a new area being
developed in Ipoh, Perak, northern Malaysia. It is expected
to cover an area of 37 hectares, and will be the largest
medical complex in Southeast Asia operated by SOCSO,
with the capacity to provide comprehensive treatment toabout 700 patients at the same time for a certain period oftime.

Schedule
June 2022 Begin construction
End of 2024 complete construction
24

Singapore
Installed to the largest medical institute in Singapore (Singapore General Hospital)
1) Obtained medical approval for HAL Lower Limb (December 2020)
2) Ships out HAL to Singapore General Hospital (July 2022)

Singapore General Hospital
The hospital is the rst and largest hospital in Singapore. It provides affordable specialist carefor patients, training for doctors and other healthcare professionals, and research to bring bettercare to its patients.Every year, the SGH Campus caters to over 1 million patients. With a 10,000strong workforce, SGH accounts for about a quarter of the total acute hospital beds in the public
sector and about one- fth of acute beds nationwide.

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Turkey
Gradually installs 36 units of HAL to private medical center (Diagenics)
1st shipment towards Diagenics Medical Center completed (July 2022)

Diagenics
The Diagenics Group was established to provide Precision Medicine
through the comprehensive use of innovative medical technologies,
including Cybernics Treatment utilizing HAL, Stem-cell therapy, andepidural stimulation therapy.

26

Neuromuscular Diseases

CYBERDYNE, Inc.

27

進行性神経筋難病：市販後使用成績調査の結果

Performance test suggests high ef cacy and safety
Ef cacy

SafetyAmbulatory function remained above
level at the beginning of the treatment over long duration

Reduced damage to the muscle tissue

Distance covered in 2 min walk
(Rate of change from the level before HAL Treatment)

CK Blood Level* *Test to identify damage to the muscle(Rate of change from the level before HAL Treatment)

Improve 43%

BeforeHAL Treatment(=1)

Improve 30%

Improve 25%

Reduced 21%
Reduced 28%
BeforeHAL Treatment(=1)

Reduced 34%
Sample of decline ofAfter
13 months

After
25 months

After
37 months

After
7 monthsfunction over time

*Due to its progressive nature, typically ambulatory function will decline over timeAfter
19 months

After
31 months*Conventional exercise therapy will accelerate the damage on the muscle tissue

Target disease: Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis,
Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophy

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Amyotrophic Lateral Sclerosis (ALS)
Journal showing the long-term walking function maintenance effect of medical HAL for the intractable ALS

Key points• All three subjects showed improvement on all three occasions before and after the HAL treatment• The average 2-minute walk distance remained higher than before the start of treatment at 300 days

◆ Published journal
Name: Internal Medicine volume 61 (2022) 10 (May 15, 2022)
Title: Effects of Long-term Hybrid Assistive Limb Use on Gait in Patients with Amyotrophic Lateral Sclerosis
Author: Harumi Morioka, Kiyoko Murata, Tatsuki Sugisawa, Mari Shibukawa, Junya Ebina, Masahiro Sawada, Sayori Hanashiro, Junpei Nagasawa, Masaru Yanagihashi, Takehisa Hirayama,
Masayuki Uchi, Kiyokazu Kawabe, Satoru Ebihara, Yoshitaka Murakami, Takashi Nakajima, Osamu Kano
DOI Number: 10.2169/internalmedicine.8030-21
URL: https://www.jstage.jst.go.jp/article/internalmedicine/61/10/61_8030-21/_pdf/-char/ja

29

Progressive spinal cord disease: expansion of indications
Additional indications: HTLV-1-associated myelopathy (HAM) and hereditary spastic paraplegia (approved)

Existing indication (2015/11)
Progressive neuromuscular diseases (8 diseases)

1. Spinal and bulbar muscular atrophy
2. Amyotrophic lateral sclerosis,
3. Spinal muscular atrophy
4. Charcot-Marie-Tooth disease
5. Inclusion body myositis
6. Distal muscular dystrophy
7. Congenital myopathy
8. Muscular dystrophy

Expanded indication (2022/10)
Progressive spinal diseases (2 diseases)

1.HTLV-1-related myelopathy
2.hereditary spastic paraplegia

Cybernics Treatment promotes the regeneration of neurological function in many diseases. It improves gait instability andfunctional disability caused by progressive intractable diseases for which no effective treatment has been established30

Establishing Cybernics Treatment as standard treatment

Information added on the Intractable Disease Information Center HP
As of October 28 2022
Intractable
DiseaseNo.

Name of intractable diseases

Intractable Disease
Information Center

Intractable Disease
Information Center

Associated Medical Society(For general users)(Summary, diagnostic criteria, etc.)(Guideline)1

Spinal and Bulbar Muscular Atrophy

Available

2

Amyotrophic Lateral Sclerosis

Available

3

Spinal Muscular Atrophy

Available

10

Charcot-Marie-Tooth Disease

Available

15

Inclusion Body Myositis

Available

18

Distal Muscular Dystrophy

26

Congenital Myopathy

30

Muscular Dystrophy

111

Spinal and Bulbar Muscular Atrophy

113

Amyotrophic Lateral Sclerosis

Available

Available
Available

Group will continue to coordinate
with associated medical societies
targeting doctors

Available

Under the support and guidance of the Ministry of Health, Labor and Welfare, the Intractable Disease Information Center provides patients with intractable diseases, their families, and medical professionals with information necessary for their medicalcare and treatment on its website https://www.nanbyou.or.jp

31

Information magazine for patients with intractable diseases
Published a magazine to support patients with progressive neuromuscular diseases and their families

Medical Supervisor: Takashi Nakajima, Neurologist
32

Spinal Cord Injury

CYBERDYNE Inc.

33

Spinal Cord Injury: Clinical Trials by German Insurance Authorities
Clinical trials to be conducted on the premise of German public medical insurance coverage
G-BA (German Federal Joint Committee) decides to conduct clinical trials under the premise of insurance coverage
G-BA approves Cybernics Treatment as the standard of care to be considered for spinal cord injury patients (in accordance with §137eSGB V of the Study Regulations)
G-BA itself decides to conduct a clinical trial (the clinical trial will be covered by public health insurance for Cybernics Treatment in advance).
The results of the clinical trial are expected to be included in the German public medical insurance system.

G-BA Preparing Protocol Framework for Clinical Trials
2022/06 G-BA solicits public comments on the protocol framework
2022/07 CYBERDYNE submits comments
G-BA (Federal Joint Committee): Organization at the federal level that determines basic bene ts, prices, standards, etc. for German insurance treatment.
§137e SGB V (Trial Regulation): A system under which the G-BA conducts its own initiated clinical trials and makes nal evaluations of promising treatments that
could become the standard of care.

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StrokeCYBERDYNE, Inc.

35

Target diseases: Stroke
Signi cant difference was observed for comparison of 6 min walking distance• 6 min walking distance (important secondary endpoint: recommended by PMDA) : superiority of HAL group was suggested.
The dispersion is less likely to in uence the result and it achieved p<0.022• 10m walking speed (primary endpoint): Result suggest greater improvement of HAL Group, but due to the number of cases, effect of dispersion remained
and the result did to achieve p<0.05
As a result of the analysis based on the data of 49 patients, excluding 3 patients who had major accidents in their daily life during the trial period, the amount of change waslarger in the HAL group than in the control group, and the di erence was statistically signi cant.

The opinion of the study coordinator that the 6-minute walking distance is an appropriate assessment"Although walking speed improves in both compensatory and physiological walking, distance measured tends toincrease in physiological walking but not in compensatory walking. As HAL is thought to remover physiological
walking, evaluation of walking distance could have been more suited for this trial. It was reasonable that the 6minute walking distance showed good results.”

Target patient : 49** acute stage stroke patient who have reached“plateau” state of improvement
Method : Patient was separated into control group and HAL
treatment group and result was compared after 20-25
session without wearing HAL
Result : Average improvement of walking distance before andafter the intervention wasControl group: 17.34 ± 4.68 m
HAL Treatment group: 34.10 ± 5.23 m

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fl

Difference
betweengroup
p=0.022

Average
improvement
17.34 mControl group : 80 min conventional rehab
HAL Treatment : 60 min conventional rehab + 20 min HAL Treatmentfi

6 min walking distanceControl group(conventional rehab)

Average
improvement34.1 mHAL Treatment
36

Status of medical device application for stroke
The clinical signi cance and statistical signi cance of the primary endpoints, which are considered themost important evaluation points of the clinical trial results, are being discussed with the authorities withthe study coordinating physicians and statistical experts.
Point (1) Clinical signi canceIn this clinical trial, the HAL Group consistently showed greater improvement than the control group in
all endpoints, etc. Therefore, if HAL therapy is applied to stroke hemiplegia patients whose recovery isstalled by conventional rehabilitation, clinically and statistically e ective improvement can be expected.
Point (2) statistical signi cance of the primary endpoints
In this trial, the p-value did not reach 0.05 due to the e ect of variance and other factors in the analysis
results of the primary endpoint of 10m maximum walking speed, but the e cacy of HAL treatment
should be considered based on the overall e ect of clinically meaningful improvement (*).
❖The ASA (American Statistical Association) statement also states the principle that "scienti c conclusions and business and policy decisions should not bebased solely on whether a p-value exceeds a certain value (signi cance level)."

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【Healthcare】Neuro HALFITCYBERDYNE, Inc.

38

Neuro HALFIT
Program to improve brain-nerve-musculoskeltal function at Robocare Center

HAL Lumbar TypeHAL Single Joint Type

HAL Lower Limb Type39

Robocare Center: Nationwide expansion of Neuro HALFIT
Expansion of hubs in the medical healthcare service business for individuals

Newly established in Saitama and Nagoya(Expanded to 18 locations nationwide)40

HAL care prevention program
Signi cant improvement in mobility functions (daily activities such as standing, walking, running, sitting) of the elderly

Care prevention program (Kanagawa Mirai MIBYO Cohort Study)
Interim evaluation results of short-term intervention twice a week for a total of 10 sessions

Evaluation item

Before HAL

After HAL

(Mean±SD)10m walk (walking speed m/sec)

Locomotiv 5 check*Signs of motor unit deterioration(Mean±SD)

Improvement rate

P-value

1.04±0.22

1.45±0.25

39%<0.001***8.15±2.48

3.96±3.15

105%<0.001***）

Subject n=80 people (Average age : 74.8 ± 4.3 years old)
Research and development of nursing care prevention programs utilizing healthcare robotsfi41

【Healthcare】Neuro HALFIT at Home (for individuals in the life stage)
Prevents the need for care by improving the function of the brain-nerve-muscular system through daily training at home

Image of use
Camera view

Angle of the body trunk(front/back)
Trial time
Angle of the body trunk(left/right)

Assist torque
Torque setting

Bioelectrical signals

HAL is data-linked with the Cyberdyne Cloud, which visualizes biopotential signals that command body
movements and posture information, etc. This system enables the wearer to obtain visual feedback andallows the trains to customize a program for each user based on the results of data analysis.

3D model display

Image of HAL Monitor
42

Strategy for growth

CYBERDYNE, Inc.

43

Image of growth scenario
Towards gradual growth
Strengthening cloud computing,personalized business, M&A, etc.

Now(evolution of the business model, M&A)
【Progress of Business in the rst half of the scal year】
・RHG (USA): Trial of New Service by HAL Begins
・RHG (USA): Expansion to 21 locations in Southern California

Expanding existing business(expanding usage, business towards
individual users, etc.)【Progress of Business in the rst half of the scal year】
・Robocare Business: Expansion to 18 facilities in Japan・Neuro HALFIT at Home: Partnership with home-visiting service providers

Developing the business base(Expanding product lineup, obtaining
regulatory approvals in each countries)【Progress of Business in the rst half of the scal year】
・Start of new medical fees for medical-use HAL (volume calculation, increased points)
・Additional indications for HAM, etc. (medical device approval)・Germany prepares clinical trial protocols for public medical insurance.
・New introduction of HAL in Turkey and Singapore

Time
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Businessscale

Reinforcing existing business,pioneering new eld

Future of medical healthcare and healthy life
Prevention/pre-symptomatic, medicine, rehabilitation/long-term care

Medical/Healthcare/Healthy life
Pre-Hospital

Hospital

Early medical・life period Prevent/pre-symptomatic

Diagnose, treat, inpatient/outpatientearly medical・life periodHousehold・work place・life space

Acute

RecoveryHospital

Post-Hospital
Late medical・life period : rehab/long-term care

Late medical・life periodHousehold・work place・life space

Squat

Squat

Close coordination, fusion between medical and non-medical field to evolve into comprehensive initiatives

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Cybernics Medical Healthcare System
Prevent, early detect and improve on daily basis (data linkage with Cyberdyne Cloud)Cybernics Medical Healthcare Systemthat prevent, early detect and improve on daily basis
Hospital, Facility, House, Workplaces

Cyberdyne Cloudwith innovative Cybernics System
Cybernics Treatment and monitoringat hospitals

Health care monitoringin daily life

Cloud
Computing

Improve independence to encouragecontinuous social activity

Sleep Apnea Syndrome,
sleep deprivation check

Activity,
sleeping check
Healthcare check and program to improvephysical function at home

Health Care Monitoring in the Workplace

Seamless data linkage between hospitals, facilities, homes, and workplaces with IoH/IoT
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Medicalcare Pit
Ef cient Cybernics Treatment with reduced therapist burden
Roboticized left-right
independent unloading control
Adjustment

If the body trunkleans strongly to one side
Weight-bearing
level set

The right and left are controlled
separately. If the trunk leans strongly to
one side, the weight reduction willautomatically be increased to adjust theleaning

Adjustment

Detection of leaning

Adjustment

If the body trunk
position drops

Weight-bearing
level set

The weight reduction will automaticallybe increased to get back to the original
position
Detection of dropped
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Medical Healthcare Service for Individuals Neuro HALFIT at Home
Expansion of remote services connecting home and hospitals/facilities through cloud computingHouse（つーざー）

LTE/5G【Integrated Cybernics System】 LTE/5G

Physical information

Physical information(User)

Cybernics Device

Monitor tablet(User)
SupportUser authentication
Device authentication
Data baseRemote service to counter the pandemic

Physicalinformation

Physical information

Monitor tablet

Cybernics Device

SupportPhysical information

Facility

SupportInduceimprovement ofbrain-nerve andphysicalfunction

Physicalinformation

SupportSupport（つーざー）(professional)

Robocare Center

Robocare Center（CYBERDYNE）（つーざー）［Cloud］

SupportInduceimprovement ofbrain-nerve andphysicalfunctionHouse

Monitor tablet

Monitor tablet（CYBERDYNE）

Professional
Staff
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Medical service business for individuals: US Business (1)Promotion of in-house platform development of medical services for individuals

RHG（RISE Healthcare Group Inc.）

Northern California
Population: over 12.2 million(Company in charge of the Group's medical service business)

Expanding business with outpatient physicaltherapy as a starting point

Both areas combined
accounts for 5% in theentire US population

LA Metropolitan area✓

Starting with San Diego, expanding to Los Angeles(2nd largest metropolitan area in the U.S.)✓

Currently 21 locations (up 5 locations since thebeginning of the year) → Several more locations tobe added by the end of the year✓

Considering expansion into northern California(through M&A, etc.)

Population: 13 million(2nd largest in US*)San Diego area

Population: 3.3 million(17th in US*)* https://en.wikipedia.org/wiki/List̲of̲core-based̲statistical̲areas

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Medical service business for individuals: US Business (2)Accumulated Cybernics Treatment results and cases in our own group

Ian - Traumatic brain injury

Robert - Parkinsons Disease

https://youtu.be/FsV7_KATh94

https://youtu.be/VnAWHvGTbbQ“…I felt myself getting closer
walking with every session thatwill drastically help because if I
can walk I can do so much more
for myself…”“…I really just enjoyed getting my
independence back getting back into
where I can walk out in the yard,
playing with the kids more and now
it's a really wonderful thing to be able
to get back into that again.”Jazzmyn - CIDP
https://youtu.be/L59PFcyAOj4“…when I rst started going to RISE
I was in a wheelchair and now I am
walking and standing.”fi

50Medical service business for individuals: US Business (3)Formulating platform that could reach individuals directly
Workplace/living space
Daily monitoring at
work and everywhere

Orthopedic+brain-nerve diseases (target of HAL)US PT
marketTypically done manually by PT (can differentiate with HAL)
Growing market due to aging population (Annually 33.1 billion=3.7 trillion yen)*
Players are dispersed (potential for further growth through M&A)

PT：Physical Therapy

Home
Healthcare check at home andfunctional recovery program

RISE Healthcare Group Inc.
→First facility in the west coast area

Medical facility
Cybernics treatment/monitoring

Functional recovery at home and daily healthcare monitoring
Preparing for launch of service towards individuals (consider further M&A)
* “Physical Therapists in the US” IBIS World
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【Prevention and early detection】Ultra small vital sensor Cyvis

Healthcare monitoring on daily basis with Cyvis
Daily accumulation, analysis, and AI processing of various vital data
・Cardiac activity
・brain activity
・body temperature
・SpO2
・Body movements
・Breathing (optional)

Check for arrhythmia and atrial brillation to prevent
myocardial infarction and cerebral infarction
Option to check breathing conditions during sleep for early detection of sleep apnea risk
*Cyvis-1 medical device noti cation led (April 2022), trial provision to users started (May 2022)
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【Prevention and early detection】Ultra small vital sensor Cyvis

Expands remote service that connects households to hospitals and facilities
House

Physical information（つーざー）(User)

User authentication
Device authentication
Data base

Induceimprovementof brain-nerve
and physicalfunction

Remote service to counter the pandemic

t
pp

or

t

Early
detection of
sleep apnea
syndromerisk

Facility(Professional)（つーざー）(User)
Monitor tablet

Mobile tablet

orSupportSupportpp

Su

Physicalinformation

Cyvis

Monitor tablet

Cybernics Device

al
ic on
ys atiPh rmfoinPhysicalinformation

Su

House

(User)
SupportInduceimprovementof brain-nerve
and physicalfunction

Early detectionof risks of
Cerebrovasculardisease, heartdisease, etc.

（つーざー）［Cloud］

SupportMonitor tablet

House

LTE/5G

Physical information

P
in hy
fo si
rm ca
at l
io
n

Cybernics Device【Integrated Cybernics System】

LTE/5GHouse（つーざー）(User)

Monitor tablet

Mobile tablet

Cyvis (Option)

Professional
Staff

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【Prevention and early detection】Photoacoustic Imaging Device using LED light array

Contrast-free, non-invasive, real-time, high-resolution 3D imaging
LED array method (patent held by the company)

Peripheral level examination,
which could not be done withconventional imaging
equipment, is now possible!
Example of application••
Adopted as the cover of
BioPhotonics, a U.S. industry
journal dealing with biophotonics••

Routine examination and diagnosis of
diabetic foot lesions
Examination of vascular regeneration
status by regenerative medicine
Examination and diagnosis of cancer
Examination of aging skin, etc.

Peripheral vascular and bloodconditions, etc.

Currently promoting medical device commercialization as a next-generation medical diagnostic imaging device
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【Prevention and early detection】Photoacoustic Imaging Device using LED light array

Introduced by prominent universities and research facilities around the world(e.g., Cambridge University, Stanford University, Johns Hopkins University, etc.)55

【Workplace】HAL Lumbar Type (Labor Support)
Visualization of workers' workload and physical condition (labor management and work ef ciency)• Can be worn for long hours
Construction sites,

Compact design• Can be used with safety belts (full-body type)(back won’t be covered)and air conditioning suits!
Assist walking
Able to move in midback position.
IoH/IoT device
Wearable Cyborg

Integrated
Cybernics System

airports, and distribution
warehouses etc.

• Can be moved smoothly on site
• Respond with assistance in a variety ofLabor
managerpractical tasks!

• Visualize workload analysis and operation status!
Integrated production management• It moves according to the wearer's intention

Can be worn in 10 sec• Easy to put on and take off, share with multiple people!

Waterproof/dustproof(IEC reg, IP54)• Can be worn outdoors, even in the rain!

Hoping to promote its
use in construction sites
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Active type andlight weight【Workplace】Disinfection/Cleaning Robot CL02
Operationalizing next-generation technologies in a post-coronary society•
Extensive•
Cleaning ability •High speed autonomous navigation (Can safely clean at 4km/h to cover massive space in short time
Massive cleaning area (Detects wall that is 30m away and cover max 3,000m2 with full charge battery)High vacuum performance (one of the best in the industry)

Airports, oCan be used for •multiple tasks such •as disinfection

Disinfection agent sprayer (Disinfects handrails and benches)••

Dust distribution map (visualizes result of the task)
Navigated route (to create ef cient and effective cleaning plan)

Visualizes
its work

UV Ray Disinfector (set on the bottom of the robot to disinfect oors)facilities, shopping
centers etc.

Human
RobotsAutomatically •rides on the•elevator

Elevator interface unit developed inhouse(Can connect to elevators developed by multiple vendors)
Can work on multiple oors (Expands the space that can be cleaned)•
Cloud linkage •“CYCLES” designed for the Robot (realizes high usability and management)
Integration with the base system

Cyberdyne
Cloud&Server

CYCLES
Cloud & Server
ce buildings,

Information transfer
and remote control

Various opportunities to provide
value in o ce buildings, large
shopping centers, etc.

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SDGs for Society 5.0/5.1

CYBERDYNE, Inc.

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Four projects that contributes to achieving SDGs

Develop Cybernics Technology tosupport people with reduced
physical function

Health Risk Management with
Cyberdyne Cloud

Main initiatives

Main initiatives• Disseminate Cybernics Treatment that
promotes functional improvement andregeneration of the brain, nervous system,
and muscular system using a Wearable
Cyborg HAL, as a global standard treatment• Develop Cyberdyne Cloud to accumulate,analyze, and perform AI processing of big
data on people and things (IoH/IoT big data)obtained through all Cybernics Technologies
equipped with communication functions• Disseminate Wearable Cyborg HAL to
improve the level of care required by theelderly and prevent severe illness and prevent
frailty and maintain independence as physicalfunctions decline with age• Realize personalized healthcare throughCyberdyne Cloud• Develop Cyin for Living Support for people
with severe disabilities who cannot speak orwrite as they wish due to the progression of
intractable diseases to communicate andoperate machines without speech or physicalmovement• Develop sensing technology to monitor vital
information daily• Develop HAL at Home as a new service thatcan share user's information on their training
sessions conducted at home using HAL withmedical and care facilities

Form social infrastructure tocreate the Cybernics Industry
Main initiatives• Establish a system to support companies andhuman resources that develop and deploy
technologies and services that solve social
problems• Construct Cybernics Innovation Base topromote innovation in the medical andbiotechnology elds
• Continue the projects at the Next-generation
multi-purpose robotized production facility to
induce innovation in the production eld

Realize Society 5.0/5.1, a futuresociety that accelerates innovation
Main initiatives• Develop mobility technologies that are safe,
affordable, and ready for use by all people• Develop a future city where all people, including
the elderly and disabled, can easily access public
spaces.
• Establish educational institutions that develop
knowledge and skills to help people.
• Create shared spaces that promote innovationand scienti c research and areas for eld testing

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Develop Cybernic Technology to support people with
reduced physical function
Our contribution

Main target
10.2 by 2030 empower andpromote the social, economic
and political inclusion of allirrespective of age, sex,
disability, race, ethnicity,
origin, religion or economic orother status

By developing the Wearable Cyborg HAL for medical and welfare elds, andCyin for Well-being to support severely disabled to communicate theirintentions, we are supporting the elderly and disabled person by
maintaining and improving their functions. We also help them express what
they have in mind.
We also develop another type of HAL to support people engaged in heavy
work.
This project promotes the empowerment of these people and their social,economic, and political inclusion.

Disseminating Medical HAL as a
global standard treatment
As of the end of September 2022,
HAL for Medical Use is available in
20 countries and regions, includingSoutheast Asia and South Asia, as atreatment technology for stroke,
spinal cord injury, and intractableneuromuscular diseases.
In addition, in order to contribute tosolving the needs of developing
countries, we have been selected by
the Japan International Cooperation
Agency (JICA) to conduct a research
project in Brazil.
We will continue to disseminate thetechnology.

Post-discharge care at the
Robocare Center

Cybernics Treatment Center andMedical HAL

HAL Lumbar Type to support
various heavy work

Cyin for Living Support to support severely
disabled person on their communication

For those who want to keep
improving their physical functions
after they get discharged from thehospital, we offer Neuro HALFIT at
self-funded rehabilitation facilities
called RoboCare Center. As of theend of September 2022, they are 17
centers around Japan. A user canalso access similar programs at selffunded rehabilitation facilities withwhich we have cooperative
relationships.
In addition, we have formed
alliances with private insurancecompanies such as Daido Life, AIG
Insurance, and Sompo Japan tocover the cost of such programs fortheir policyholders.
We will continue our efforts toimprove physical and economic
access.

Improving the working environment
Job turnover due to the onset of backpain and the deterioration of
performance caused by frequent
heavy lifting is becoming a signi cantissue in nursing care, construction,and logistics.
The Company develops HAL
Lumbar Type to reduce the risk ofdeveloping back pain by reducing theload applied to the lower back. The
technology empowers people
engaged in heavy lifting and enables
the worker to continue working longer
and safer.
As of the end of September 2022,
1,598 units of HAL Lumbar Type
were in operation.
This product is currently available inJapan and the UK. We will continue
to disseminate the technology tomore countries and regions.

Supporting communication for theseverely disabled
We develop Cyin for Living Support,
which enables people with severe
disabilities who cannot speak or movetheir bodies due to the progression of
intractable diseases to communicate
and operate devices.
The product is available on themarket. Daido Life Insurance donatedthe product to several patient groups
and patient support groups to promote
this endeavor.
We will continue to work on additional
functions and offer the product outsideof Japan once it is ready.

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Our contribution

Release of Cyberdyne Cloud

Cybernics Technology deployed in various elds such as medicine, nursingcare, production, and other workplaces with households, integrally connects
people's internal information (brain nerve information, physiologicalinformation, etc.), people's external information (behavioral information,
lifestyle information, etc.), and environmental information with asupercomputer.
The Company works on the system that accumulates, analyzes, and AI
processes all the IoH/IoT Big Data obtained through this process,contributing to personalized medicine, early warning of health risks, andenhancing risk mitigation and risk management capabilities.

Main target
3.d Strengthen the capacityof all countries, in particulardeveloping countries, forearly warning, risk reduction
and management of nationaland global health risks

The Company develops Cyberdyne
Cloud to connect different elds andprovide feedback on health risks
based on IoH/IoT Big Data. In Japan,
a system that allows users to send
information on their training sessions
from home to a facility and receive
timely support from the facility isalready in operation from November
2020.
We will continue to expand thissystem to other elds according to
the development of products andservices. We will also offer thesystem outside Japan to contribute tohealth management in all countries,
including developing countries.

Realizing personalized
healthcare
Cybernics Medical Healthcare Systemthat prevent, early detect and improve on daily basis“Hospital”, “Facilities”, “Household”, “Workplaces"

Cybernics Cloudwith innovative Cybernics System

Cybernics Treatment andmonitoring at hospitals

Health care monitoringin daily life

Cloud
Computing

Improve independence toencourage continuoussocial activity

Sleep Apnea Syndrome,
sleep deprivation check
Activity,
sleeping check

Healthcare check and program to improvephysical function at home

By accumulating, analyzing, and AIprocessing IoH/IoT Big Data related
to a single user across different
elds, we will realize personalized
healthcare that will maximize theeffect and safety of that user.
This initiative is being carried out
simultaneously with the formation of
IoH/IoT Big Data for all users. We willcontinue to expand this system toother elds according to thedevelopment of products andservices. We will also offer thesystem outside Japan to contribute tohealth management in all countries,
including developing countries.

Developing vital sensing
technology
In addition to developing the
Wearable Cyborg HAL andautonomous navigation technology,
we are developing sensing
technology to prevent and detect
diseases.
For example, commercialization ofCyvis, an ultra small-sized vital
sensor to detect arteriosclerosis andarrhythmia at an early stage, and aphotoacoustic imaging device toenable real-time analysis of capillary
information.
By promoting these products, we willaccumulate important vital
information that will lead to theprevention and early detection of
diseases, thereby contributing to theenhancement of capabilities forhealth risk management.

New service: HAL at Home
HAL at Home is a new service thatenables safe and effective training at
home. HAL at Home also realized thevisualization of exercise information
and remote online support by
professional staff through HAL's builtin communication functions.
The Company is also working to
expand home visiting services so that
seniors who have concerns about
handling digital devices can also
engage in the program.

Health Care Monitoringin the Workplace

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Health Risk Management with Cyberdyne CloudOur contribution
We are working to create an inclusive and sustainable industry called
Cybernics Industry by building an innovation ecosystem called C-Startup
and facilities to accelerate innovation in medicine/biotechnology andproduction.
C-Startup, the foundation for the creation of new industries

Main target
9.2 Promote inclusive andsustainable industrialization
and, by 2030, signi cantly
raise industry’s share of
employment and grossdomestic product, in line withnational circumstances, anddouble its share in least
developed countries

C-Startup is an innovation ecosystem to create a new industry for solving problems ofpeople and society: Cybernics Industry. We work together with startups and entrepreneurs
with similar visions, regardless of their nationalities.
We accelerate creating the Cybernics Industry by providing technical advice by Yoshiyuki
Sankai (CEO of CYBERDYNE/Professor of Tsukuba University) and nancial support by
CYBERDYNE and its related Fund.
As part of this initiative, we have formed partnerships with a total of 21 startups and aremanaging a 10 billion yen fund to support this endeavor.
Cybernics Industry

University andresearch institutions

Promoting the vision of the Cybernics
Industry
The Company promotes the vision of the
Cybernics Industry, a new industry that fuses
Human and Cyber/Physical Space, both
domestically and internationally. With thisinitiative, we are leading the efforts to form
Cybernics Industry together with industry,
academia, and government.
For example, in 2019, we communicated thisvision to various countries at the G20 Trade andDigital Economic Ministerial Meeting held in
Tsukuba City, Ibaraki Prefecture.
We will continue to share our vision of the
Cybernics Industry as a foundation for industrial
and technological innovation.

Start-ups andentrepreneurs

bio/drug discovery

Med Tech

2020/12 listed

C-Startup

regenerative
medicineBig
Data

Technical advices
Financial support
Business support

2022/12 listed

Cutting-edge
technology

IoH/IoT
Robotics

CYBERDYNEAI

CEJ Fund (scale of 10 billion)

University, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the 21st
century
Smart city council etc,.

Medical institutions,care facilities, companies,
allied partners

2022.9.27 updated

G20 delegates visit CYBERDYNE HQ (2019)

Construction of Cybernics Medical Innovation Base

Exterior image

We plan to construct the Cybernics Innovation Base in
Kawasaki City, Kanagawa Prefecture, as a facility toaccelerate innovation in the medical and biotechnology
elds. The facility will house a cluster of medical andbiotechnology ventures. The Company, universities, andresident companies can conduct a clinical trial in thefacility on their own and through collaboration.
The facility is planned to start operation within thescal year ending March 2022.

Activities at the Next-Generation
Multipurpose Robotic ManufacturingBase
In Koriyama City, Fukushima Prefecture, we haveconstructed a next-generation production base to
produce robots and devices with Cybernics
Technology. In this facility, the Company
embedded the skills of experienced workers into
the robots so the robots and human workers canwork in harmony.
The Company constructed the facility in 2016
and completed a registration to manufacture
medical devices in 2020.

Exterior of the facility

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Form social infrastructure to create the Cybernic Industry

Realize Society 5.0/5.1, a future society that accelerates innovation
Our contribution
Using innovative Cybernics Technology, we promote the fusion of Humanand Cyber/Physical Space to create Society 5.0/5.1. We envision this futuresociety as a techno-peer-supported society where technology and human
support each other as partners.
Creation of Society 5.0/5.1

Main target
11.2
by 2030, provide
access to safe, affordable,
accessible and sustainabletransport systems for all,i m p r o v i n g r o a d s a f e t y,notably by expanding public
transport, with special
attention to the needs ofthose in vulnerable
situations, women, children,
persons with disabilities andolder persons
11.7
by 2030, provide
universal access to safe,
inclusive and accessible,
green and public spaces,
particularly for women andchildren, older persons andpersons with disabilities

Society 5.0 is a concept rst proposed in Japan's Fifth Science and Technology Basic
Plan as the ideal future society. In this society, science and technology connect all people
and things, sharing various knowledge and information to create new values never seen
before.
We contribute to the creation of Society 5.0 by implementing Cybernics Technology inthe various business elds to integrate internal information (brain nerve information,
physiological information, etc.), people's external information (behavioral information,
lifestyle information, etc.), and environmental information with a supercomputer. As one of
the leaders in this challenge, we work to explore the society beyond Society 5.0/5.1.

Mobility Infrastructure

Futuristic housing

We are working on personal mobility
and drones for transportation that issafe, inexpensive, and easy to use,taking into consideration the needs ofthe elderly and disabled living in thecommunity.
We are also planning cities basedon the premise of introducing
mobility, which will shorten travel timeand create new connections andadded value between functions andfacilities.
While developing mobility
infrastructure in-house, we are alsocollaborating with startups that aredeveloping related technologies.

Through daily health management
and lifestyle support infrastructure
based on Cybernics Technology, we
will develop housing where all
people, including the elderly anddisabled, can live in harmony withtechnology and mutually support
each other to ensure peace of mind.
Speci cally, various Cybernics
Technologies, such as the Wearable
Cyborg HAL, autonomous navigation
robots, and vital sensors, will be
introduced into every space,including residences. Personal healthinformation will be accumulated,
analyzed, and processed by AI to belinked to medical facilities to manage
each person's health and safety
better.

Shared Economy
We plan to shift from the conventionalmodel of occupying information,
people, goods, space, and time to a
new form of a city where we can shareand help each other.
We will work to achieve successwith the allies formed in C-Startup. We
will also continue to gather people andcompanies with seeds related to
Cybernics and accelerate the creationof innovation through sharing andmutual aid of information, people,
goods, space, and time.

An educational institution that
nurtures the next generation ofhuman resources
Through collaboration between
industry, academia, and government,
we are planning an educational
institution to foster the next generationof innovators.
We will nurture the next generationof innovators with educational
institutions ranging from graduate
school to elementary school, taught by
instructors from various companies.

perspective drawing of the future city

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Disclaimer

This presentation contains forward-looking statements concerning
CYBERDYNE, Inc. and its Group’s future plans, strategies and performance.
Forward-looking statements contained in this presentation are based on
information currently available and on certain assumption redeemed rational at
the time of creation of this presentation. As such, due to various risks anduncertainties, the statements and assumption does not guarantee future
performance, may be considered differently from alternative perspectives andmay differ from the actual result.
Further, this presentation contains statements and information regarding
corporate entities other than those belonging to the CYBERDYNE group, whichhave been complied from various publicly- available sources. CYBERDYNE
does not verify nor guarantees accuracy and appropriateness of those
information.

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