੕ହ

ৎ৑౭ു৾৵ি ඥೣ叞‫؞‬রਣ ෥ஂ‫؞‬ཚ ᆧส‫؞‬স ੗ལ੡ଽોপ৾প৾੹ে୵஗৾ଢ଼஢ఐ

ྂࡃ࠿ࡽࠕつ๎ṇࡋ࠸㣗⏕άࡣ೺ᗣ࡟⛎ジࡔࠖ࡜࠸ࢃࢀ࡚࠸ࡿࠋ᫬㛫⏕≀Ꮫࡢ㐍Ṍࡀᴫ᪥᫬ィࡢ㌿෗ࢿ࢞ࢸ࢕ࣈ࣭ࣇ࢕࣮ࢻࣂࢵࢡไᚚࢆ᫂ࡽ࠿࡟ࡋࠊయࡢࡍ࡭࡚ࡢ⣽⬊ࡀࡑࡢ᫬ィࢩࢫࢸ࣒ࢆഛ࠼࡚࠾ࡾࠊ⫢⮚ࢆࡣࡌࡵ࡜ࡋ࡚ෆ⮚ࡢ᫬ィࡀ㣗஦࡟ࡼࡾྠㄪࢆཷࡅࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ㣗஦ࡢࢱ࢖࣑ࣥࢢࡣࠊෆ⮚᫬ィࡢྠㄪࢆ௓ࡋ࡚⬡㉁௦ㅰࢆࡣࡌࡵ࡜ࡍࡿ࣐ࢡࣟᰤ㣴⣲ࡢ௦ㅰࢆไᚚࡋ࡚࠸ࡿࠋࡑࡋ࡚ࠊ୙つ๎࡞㣗⏕άࢆࡍࡿ࡜ࠊ⬡㉁௦ㅰ␗ᖖࢆㄏⓎࡋ࡚ࠊ⫧‶ࡸ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟ࡞࡝࡟⤖ࡧࡘࡃࡇ࡜ࡀศ࠿ࡗࡓࠋ୍᪉ࠊ
つ๎ṇࡋ࠸㣗⏕άࢆࡍࡿ࡜࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡢண㜵࡟࡞ࡿࡇ࡜ࡶࢃ࠿ࡗࡓࠋ㣗஦ࡢࢱ࢖࣑ࣥࢢࡣ
೺ᗣⓗ࡞యෆ᫬ィࢆᙧᡂࡋࠊࡇࡢ㣗஦ࡢࢱ࢖࣑ࣥࢢ࡟ࡼࡗ࡚ᙧᡂࡉࢀࡿయෆ᫬ィࡣಶேࡢᐃ㔞ⓗ࡞య㉁࡜
ࡋ࡚࡜ࡽ࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࠋᴫ᪥ࣜࢬ࣒ࢆࡣࡌࡵ࡜ࡍࡿࡉࡲࡊࡲ࡞⏕యࣜࢬ࣒ࡢ⥲యࢆࣜࢬ࣮࣒ࣔ
㸦rhythmome㸧࡜ࡋ࡚࡜ࡽ࠼ࡿ࡜ࠊ೺ᗣࢆ⥔ᣢࡍࡿࡓࡵಶே໬ᑐᛂࡋࡓ་⒪ࡸᰤ㣴Ꮫࡢᇶ┙ࢹ࣮ࢱ࡜ࡋ࡚
࡜ࡽ࠼ࡿࡇ࡜ࡀྍ⬟࡟࡞ࡿࠋ㣗஦ࡢࢱ࢖࣑ࣥࢢࡀࠊ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡸ⏕ά⩦័⑓࡟ᙳ㡪ࢆཬࡰࡍࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ᫬㛫ᰤ㣴Ꮫ࡟ࡘ࠸࡚⤂௓ࡍࡿࠋ
1. ࡣࡌࡵ࡟

⌧௦᪥ᮏ㣗ࡢၥ㢟Ⅼ࡜ᰤ㣴Ꮫࡢㄢ㢟ࡉࢀࡿ࡞࡝ࠊ೺ᗣⓗ࡞㣗஦࡜ࡋ࡚ࡔࡅ࡛࡞ࡃࠊ᪥ᮏࡢ

ࡍ࡭࡚ࡢᚲ㡲ᰤ㣴⣲ࡣ 20 ୡ⣖༙ࡤ࡟ࡣỴࡵࡽࢀࠊ㣗ᩥ໬ࡀୡ⏺࠿ࡽὀ┠ࢆᾎࡧ࡚࠸ࡿࠋࡑࢀ࡛ࡣࠊ⚾ࡓᰤ㣴⣲ࡢ୙㊊࡟ࡼࡿ⑌ᝈࡣ⌮ㄽୖゎỴࡉࢀࡿࡇ࡜࡟

ࡕࡀ㣗࡭࡚࠸ࡿ⌧௦ࡢ᪥ᮏ㣗ࡣᯝࡓࡋ࡚೺ᗣ㣗࡞ࡢ࡞ࡗࡓ㸦ࠕ୙㊊ࡢᰤ㣴Ꮫࠖ㸧ࠋࡑࡢ࡯ࡰྠ᫬௦࡟ᰤ㣴⣲ࡔࢁ࠺࠿ࠋࠕᅜẸ೺ᗣ࣭ᰤ㣴ㄪᰝࠖࢆࠊᰤ㣴ᚲせ㔞ࢆࡢ㐣๫ࡢ᫬௦࡟࡞ࡾࠊᰤ㣴ࡢ㐣๫࡟ࡼࡿ⫧‶ࡸ⏕ά⩦⛉Ꮫⓗ࡟Ỵࡵࡓࠕ᪥ᮏேࡢ㣗஦ᦤྲྀᇶ‽ࠖ࡜ẚ㍑ࡍࡿ

័ࡀၥ㢟どࡉࢀࡿࡼ࠺࡟࡞ࡗࡓ㸦ࠕ㐣๫ࡢᰤ㣴Ꮫࠖ㸧ࠋ࡜ࠊ㣗≀⧄⥔࡜࣒࢝ࣜ࢘ࡀ୙㊊ࡋࠊ୍㒊ࡢࣅࢱ࣑ࣥࢆ᫬௦ࡢせㄳ࡟ࡇࡓ࠼ࠊᰤ㣴Ꮫࡣᇶ♏࠿ࡽᐇ⏕ά࡬ᑐᛂࡶࡗ࡜ྲྀࡗࡓ᪉ࡀⰋࡃࠊࢼࢺ࣒ࣜ࢘ࡀ㐣๫࡛࠶ࡿࡇ࡜

ࡍࡿࡼ࠺࡟࡞ࡾࠊ⫧‶ࡸ⏕ά⩦័⑓ࡢቑຍࢆண㜵ࡋࡼࡀࢃ࠿ࡿࠋࡇࡢၥ㢟ࡣ㔝⳯࡜㨶࡜ㄪ࿡ᩱࡢᦤྲྀࡢၥ㢟࠺࡜ࠊ࢚ࢿࣝࢠ࣮ࡸ㣬࿴⬡⫫㓟ࢆከࡃྵࡴ㣗ရࡢྲྀࡾ࡜⨨ࡁ᥮࠼ࡿࡇ࡜ࡀ࡛ࡁࡿ࡜⪃࠼࡚࠸ࡿࠋ㔝⳯ࡢᦤྲྀ㐣ࡂ࡟ྲྀࡾ⤌ࢇ࡛ࡁࡓࠋ⡿ᅜࢆ୰ᚰ࡟࠸ࢃࡺࡿࢪࣕࣥ

ࡀ༑ศ࡛࡞ࡃࠊῶᑡഴྥ࡛ࡍࡽ࠶ࡿࠋ㔝⳯ࡣⱝ࠸㡭ࡢࢡࣇ࣮ࢻࢆῶࡽࡑ࠺࡜࠸࠺࣮࢟ࣕࣥ࣌ࣥࡀ⾜ࢃࢀࠊᡂ㣗⩦័ࡀᖺࢆྲྀࡗ࡚ࡶኚ໬ࡋ࡞࠸ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞

ຌࢆ཰ࡵ࡚࠸ࡿ୍᪉࡛ࠊ⬡㉁࠿ࡽࡢ࢚ࢿࣝࢠ࣮ᦤྲྀࡀࡾࠊ 㔝࡛⳯ࡂࡹࡗ࡜ワࡵࡿ࡞࡝㔝⳯ࢆ㣗࡭ࡿࢫࢱ࢖

ῶࡿࡶࡢࡢ⫧‶ࡀቑ࠼ࡿ࡞࡝⓶⫗࡞≧ἣࡶ⏕ࡲࢀ࡚ࣝࢆኚ࠼ࡿᚲせࡀ࠶ࡿࠋ㞴ࡋ࠸ၥ㢟࡛࠶ࡿࡀࠊῶሷࡣ

ࡁࡓ 1ࠋࠕ୙㊊ࡢᰤ㣴Ꮫࠖ࡟ຠᯝⓗ࡛࠶ࡗࡓ㞟ᅋ࡟ᑐࡍᡂຌࡋ࡚࠸࡞࠸኱ࡁ࡞ㄢ㢟࡛࠶ࡿࠋࡇࢀࡀ⌧௦ࡢ᪥ᮏࡿᰤ㣴ᣦᑟࡀࠊࠕ㐣๫ࡢᰤ㣴Ꮫࠖ࡟࠺ࡲࡃᑐᛂ࡛ࡁ࡚

㣗ࡢ⌧≧࡛࠶ࡿࠋ

࠸࡞࠸ࡇ࡜ࡀศ࠿ࡾࠊ⌧ᅾ࡛ࡣࡶࡗ࡜ಶே࡟ᑐᛂࡋࡓ
ࠕ᭱㐺໬ࡢᰤ㣴Ꮫ㸦ࣉࣞࢩࢪࣙࣥᰤ㣴Ꮫ㸧ࠖࡀồࡵࡽ

2. ᭱᪂ᰤ㣴Ꮫ㸸᫬㛫ᰤ㣴Ꮫ࡜⭠ෆ⣽⳦ᰤ㣴Ꮫࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁ࡚࠸ࡿ 2ࠋ⏕ά⩦័⑓ࡢண㜵ࡔࡅࡇࡢࡼ࠺࡞⫼ᬒࡢ୰ࠊ᭱㏆࡟࡞ࡾ࠿ࡘ࡚ࡢᰤ㣴Ꮫ࡛ࡌࡷ࡞ࡃࠊ౛࠼ࡤ㐠ື㑅ᡭࡀࠊࣃࣇ࢛࣮࣐ࣥࢫࢆୖࡆ

ㄆ㆑ࡉࢀ࡚ࡇ࡞࠿ࡗࡓ೺ᗣ࡟኱ࡁ࡞ᙳ㡪ࢆཬࡰࡍᰤ

ࡿࡓࡵ࡟࡝࠺ࡋࡓࡽ࠸࠸࠿ࠊ೺ᗣ࡛೺ࡸ࠿࡞ຍ㱋ࢆ࡝㣴Ꮫⓗ▱ぢࡀ᫂ࡽ࠿࡟࡞ࡗ࡚ࡁࡓࠋࡑࡢ୍ࡘࡀ⭠ෆ⣽࠺ᐇ⌧ࡋ࡚࠸ࡃ࠿࡞࡝ಶே࡟ᑐᛂࡋࡓᰤ㣴Ꮫࡀồࡵ⳦ࡢ㔜せᛶ࡛࠶ࡿ 3ࠋࡇࢀࡲ࡛௨ୖ࡟㣗≀⧄⥔࡞࡝኱ࡽࢀ࡚࠸ࡿࠋ

⭠ࡲ࡛ᒆࡃ㣗ရᡂศ࡜⭠ෆ⣽⳦ࡢ㛵ಀࡀ೺ᗣ࡟㔜せ᪥ᮏ㣗ࡣࠊ࿴㣗࡜ࡋ࡚ࣘࢿࢫࢥ↓ᙧᩥ໬㑇⏘࡟Ⓩ㘓

ࡔ࡜࠸࠺ࡇ࡜ࡀࢃ࠿ࡗ࡚ࡁࡓ 4ࠋࡶ࠺୍ࡘࡀࠊ㣗஦ࡢ‫ݩ‬hirooda@agr.nagoya-u.ac.jp᫬㛫⏕≀Ꮫ

Vol. 26, No. 1 (2020)21

ࢱ࢖࣑ࣥࢢࡢࠕ᫬㛫ᰤ㣴Ꮫ࡛ࠖ࠶ࡿ 5ࠋࡘࡲࡾࠊ࡝ࢇ

ᚚᶵᵓࡀ⏕≀᫬ィࡢᇶᮏ࡛࠶ࡿࡇ࡜ࡀゎ᫂ࡉࢀࡓ 16ࠋ࡞ࡶࡢࢆ㣗࡭࡚࠸࡚ࡶࢱ࢖࣑ࣥࢢࡀᝏ࠿ࡗࡓࡽ୙೺

ࡉࡽ࡟⩻ヂᚋಟ㣭࡟ࡼࡗ࡚ࡶᴫ᪥᫬ィࡀไᚚࡉࢀࡿ

ᗣ࡟࡞ࡿ 6,7ࠋఱࢆ㣗࡭ࡿ࠿௨ୖ࡟㣗࡭ࡿࢱ࢖࣑ࣥࢢࡀ

ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ 17ࠋ➨ 3 ࡢไᚚᶵᵓ࡜ࡋ࡚ࠊ㔜せࡔ࡜࠸࠺ࡇ࡜ࡀࢃ࠿ࡗ࡚ࡁࡓࠋmRNA ࡢᏳᐃᛶไᚚ࡟ࡼࡿᴫ᪥ࣜࢬ࣒ࡢᙧᡂࡀ♧၀

ᖹᡂ 30 ᖺᅜẸ೺ᗣ࣭ᰤ㣴ㄪᰝ࡟ࡼࡿ࡜ࠊ᪥ᮏேࡢ

ࡉࢀࡿࡼ࠺࡟࡞ࡗࡓ 18ࠋ⚾ࡓࡕࡶࠊࣛࢵࢺ⫢⮚࡛᫬ィ

5 ศࡢ 1 ࠿ࡽ 6 ศࡢ 1 ࡣ⢾ᒀ⑓ࡀᙉࡃ␲ࢃࢀ࡚࠸ࡿࠋ

㑇ఏᏊࡢ୰࡛ࠊᑡᩘࡢ᫬ィ㑇ఏᏊࡢࣜࢬ࣒ࡀ mRNA≉࡟⏨ᛶ࡛ࡣ⫧‶ࡀቑ࠼࡚࠸ࡿࠋ࢚ࢿࣝࢠ࣮ᦤྲྀࡣⱝ

ࡢᏳᐃᛶ࡟ࡼࡗ࡚ไᚚࡉࢀࡿྍ⬟ᛶࢆぢฟࡋࡓ㸦ᮍⓎᖸῶࡗ࡚࠸ࡿ࡟ࡶ࠿࠿ࢃࡽࡎࡇࡢ⌧㇟ࡀ㉳ࡁ࡚࠸ࡿࠋ

⾲㸧
ࠋ

ୖ࡛㏙࡭ࡓࡼ࠺࡞ࠊ≉ᐃᰤ㣴⣲ࡢ㐣୙㊊࡟ࡼࡿࡶࡢ࡛

୍᪉ከࡃࡢ௦ㅰⓗࠊ⏕໬Ꮫⓗ⌧㇟࡟ࡶࣜࢬ࣒ࡀ࠶ࡿ

ࡣ࡞࠸ࠋࡑࢀ࡛ࡣࠊ௚࡟࡝ࡢࡼ࠺࡞ᅉᏊࡀၥ㢟࡛࠶ࢁ

ࡇ࡜ࡀ 1980 ᖺ௦࡟ࡣ┒ࢇ࡟ㄪ࡭ࡽࢀࡓࠋ௦ㅰࡢ୰ᚰ

࠺࠿ࠋࡸࡣࡾ㣗ࡀ㔜せ࡛࠶ࢁ࠺࡜⪃࠼ࠊ⚾ࡓࡕࡣࠊࠕఱ࡛࠶ࡿ⫢⮚࡛ࡣࠊࡑࡢศ໬⾲⌧ᆺࢆỴࡵࡿ⫢⮚≉␗ⓗࢆ㣗࡭ࡿ࠿ࠖࡔࡅ࡛࡞ࡃࠊ㣗࡭᪉㸦㣗ࢫࢱ࢖ࣝ㸧ࡀ㔜㌿෗ᅉᏊࡀḟࠎࢆࢡ࣮ࣟࢽࣥࢢࡉࢀࠊ⫢⮚Ⓨ⏕࡞ࡽࡧどࡔࢁ࠺࡜⪃࠼ࡓࠋ࡟⫢⮚ศ໬⾲⌧ᆺࡢศᏊⓗ⫼ᬒࡀ᫂ࡽ࠿࡟࡞ࡗࡓ 19ࠋࡇࢀࡲ࡛ᰤ㣴Ꮫࡣࠊ୺࡟ࠕఱࢆࠖ㣗࡭ࡿࡢ࠿࡟ὀ┠⫢⮚≉␗ⓗ㌿෗ᅉᏊࡢ୰࡛ࠊDBP ࡣ㞳ஙᚋ࡟ᛴ⃭࡟ࡋࡍࡂ࡚ࡁࡓࠋ
⚾ࡓࡕࡣࠊ
ࠕㄡࡀ
㸦Who㸧
ࠕ
ࠖఱࢆ
㸦What㸧
ࠖⓎ⌧ࡀஹ㐍ࡍࡿࡓࡵࠊ⫢⮚Ⓨ⏕ࡢ᭱ᚋ࡟Ⓨ⌧ࡋࡑࡢᡂ

ࠕ࠸ࡘ㸦When㸧ࠖࠕ࡝ࡇ࡛㸦Where㸧ࠖࠕ࡝ࡢࡼ࠺࡟

⇍ࠊࡘࡲࡾ኱ேࡢ⫢⮚࡟ࡍࡿ㌿෗ᅉᏊ࡛࠶ࡿ࡜⪃࠼ࡽ

㸦How㸧ࠖ㣗࡭ࡿࡢ࠿ࠊ
ࠕ㣗ࡢ 5W1H㸦㣗ࢫࢱ࢖ࣝ㸧ࠖࠊࢀࡓࠋ1990 ᖺ࡟ DBP ࢆࢡ࣮ࣟࢽࣥࢢࡋࡓ Schiblerࡘࡲࡾ㣗࡭᪉ࢆ⥲ྜⓗ࡟⪃࠼࡚ึࡵ࡚ᰤ㣴ࢆ⌮ゎ࡛ࡽࡣࠊྠࡌᖺ࡟ DBP ࡀᴫ᪥ࣜࢬ࣒ࢆ♧ࡍࡇ࡜ࢆሗ࿌

ࡁࡿࡣࡎ࡛࠶ࡿ࡜⪃࠼ࡿࡼ࠺࡟࡞ࡗࡓ㸦
ࠕ࡞ࡐ㸦Why㸧ࠖࡋࡓ 20,21ࠋ➨ 1 ⴭ⪅ࡢኪᆺࡢ࣏ࢫࢻࢡ࡜ࡑࡢᚋ࡟◊✲࡟ࡘ࠸࡚ࡣࠊ8 ࢆཧ↷㸧ࠋྂ࠸᪥ᮏࡢ᭩≀࡛ࡶᮅ㣗ࡢ㔜ᐊ࡟ཧ⏬ࡋࡓᮅᆺࡢ༤ኈㄢ⛬ࡢᏛ⏕ࡀᚓࡓ␗࡞ࡿ⤖せᛶࡀᣦ᦬ࡉࢀ࡚࠾ࡾ 9,10ࠊ⚾ࡓࡕࡣ⤒㦂ⓗ࡟㣗஦ࡢᯝ࡟ᝎࢇࡔࡇ࡜࠿ࡽࠊDBP ࡀᴫ᪥ࣜࢬ࣒♧ࡋ᫬ィ㑇ࢱ࢖࣑ࣥࢢࡢ㔜せᛶࢆㄆ㆑ࡋ࡚࠸ࡓࠋᐇ㝿ࠊኪ໅ࡍࡿ

ఏᏊ࡟ྵࡲࢀࡿ㌿෗ᅉᏊ࡛࠶ࡿⓎぢ࡟ࡘ࡞ࡀࡗࡓࡇ

ே࡟ෙ≧ື⬦⑌ᝈࡸ⫧‶࡞࡝ࡢ⑓Ẽࡀከ࠸ࡇ࡜ࡣ௨

࡜ࡣ᭷ྡ࡞㐓ヰ࡛࠶ࡿ 22ࠋ⚾ࡓࡕࡶ๰⸆◊✲࡟ᚲせ࡞๓࠿ࡽࢃ࠿ࡗ࡚࠸ࡓ 11ࠋࡲࡓࠊࢩࣇࢺ࣮࣮࣡࢝࡜࢞ࣥ

ึ௦ᇵ㣴⫢⣽⬊ࡢᶵ⬟ࢆ⫢⮚ࣞ࣋ࣝ࡟⥔ᣢࡉࡏࡿࡓ

ࡢ㛵㐃ࡶᣦ᦬ࡉࢀ࡚ࡁࡓ 12ࠋ⌧௦♫఍࡛ࡣ㡹ᙇࡗ࡚άࡵࠊᾮᛶᅉᏊࡸ⣽⬊እ࣐ࢺࣜࢡࢫ࡞࡝ࢆ᳨ウࡍࡿ୰㌍ࡋ࡚࠸ࡿேࡓࡕ࡯࡝ࠊ஘ࢀࡓ⏕άࢆ㏦ࡗ࡚࠸ࡿࡢࡀ

࡛ࠊ1995 ᖺ࡟⫢⮚≉␗ⓗ㌿෗ᅉᏊࡢ HNF-4 ࡀ⫢⮚⌧≧࡛࠶ࡿࠋࡇࢀࡽ௙஦᯶つ๎ṇࡋ࠸⏕άࡀ࡛ࡁ࡞࠸

ศ໬⾲⌧ᆺࢆỴᐃࡍࡿୖ࡛᭱ࡶ㔜せ࡛࠶ࡿࡇ࡜ࢆぢேࡶከ࠸ࠋ᫬㛫⏕≀Ꮫࡢ㐍Ṍ࠿ࡽࠊ㣗࡭ࡿࢱ࢖࣑ࣥࢢ

ฟࡋࡓ 23ࠋࡉࡽ࡟⫢⮚≉␗ⓗ㌿෗ᅉᏊ࡜ࡋ࡚ࡢ DBP

ࢆ⪃࠼ࡓࠕ᫬㛫ᰤ㣴Ꮫࠖࡀᡂຌࢆ཰ࡵࡿࡼ࠺࡟࡞ࡗ࡚

ࡢ⫢ศ໬࡟୚࠼ࡿᙳ㡪ࢆㄪ࡭࡚࠸ࡓࠋࣛࢵࢺึ௦ᇵ㣴ࡁࡓࠋྂᕝࡣ㸦௨ୗᩗ⛠ࡣࡍ࡭࡚␎ࡍ㸧ࠊᖹᆒᑑ࿨ࢆ

⫢⣽⬊ࡣࠊࣛࢵࢺ⫢⮚࠿ࡽ⫢⣽⬊ࢆㄪ〇ࡋ࡚ࠊᬑ㏻༗

ᕥྑࡍࡿᅉᏊࡀࠕᐩࠖ࡜ࠕ᝟ሗ࡛ࠖ࠶ࡿࡇ࡜♧ࡋࡓ 13ࠋ๓୰࠿ࡽᇵ㣴ࢆጞࡵࡿࡇ࡜࡟࡞ࡿࠋึ௦ᇵ㣴࡟ࡣ⏕Ꮡࠕᐩࠖࡢቑຍ࡜࡜ࡶ࡟㣗࡭ࡓ࠸ࡶࡢࡣ࡯࡜ࢇ࡝ఱ࡛ࡶ

⋡ࡢⰋ࠸⫢⣽⬊ࢆㄪ〇ࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࡓࡵࠊࡑࢀ

㣗࡭ࡽࢀࡿࡼ࠺࡟࡞ࡾࠊ㣗࡭≀ࠊ㣗࡭᪉ࡢࠕ᝟ሗࠖࡀ

࡟ᡭࡇࡎࡿ࡜ኤ᪉࠿ࡽኪ࡟࠿ࡅ࡚ᇵ㣴ࢆ㛤ጞࡍࡿࡇᖹᆒᑑ࿨ࠊ೺ᗣᑑ࿨ࢆྥୖࡉࡏࡿ࢝ࢠ࡟࡞ࡗ࡚࠸ࡿࠋ

࡜ࡀ࠶ࡿࠋ࡜ࡇࢁࡀ DBP ࡢⓎ⌧࡟኱ࡁ࡞ࡤࡽࡘࡁࡀ
࠶ࡾᏳᐃࡋ࡞࠸࡜࠸࠺ၥ㢟࡟✺ࡁᙜࡓࡗࡓࠋ㏻ᖖࡢᇵ㣴⣽⬊࡛࠶ࢀࡤࠊᇵ㣴㛤ጞ᫬㛫ࢆ 0 ᫬㛫࡜ࡍࡿࡀࠊึ

3. ᫬㛫ᰤ㣴Ꮫࡢ₻ὶ⏕≀᫬ィࡣࠊ⏕≀ࡢᇶᮏ⌧㇟ࡢ୍ࡘ࡜ࡋ࡚ᗈࡃㄆ㆑

௦ᇵ㣴⫢⣽⬊࡛ࡣࠊఱ᫬࡟ㄪᩚࡋࡼ࠺ࡀࠊࣛࢵࢺࡀ⏕ࡉࢀࠊ⮫ᗋⓗ࡟ࡣ╧╀㞀ᐖࡢၥ㢟࡜ࡋ࡚㔜せ࡞ㄢ㢟࡛ࡁ࡚࠸ࡓࡽఱ᫬࠿࡜࠸࠺ࡇ࡜ࢆᇶ‽࡟᫬㛫ࢆྜࢃࡏ࠶ࡗࡓࠋ1971 ᖺ࡟ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢࣜࢬ࣒␗ᖖኚ

ࡿ࡜ࢹ࣮ࢱࡀࡑࢁࡗࡓࠋࡇࢀࢆࡁࡗ࠿ࡅ࡟ࠊ⫢⣽⬊ࡢ

period ࡜࠸࠺ࢩࣙ

᫬㛫⏕≀Ꮫ࡟ཧධࡍࡿࡇ࡜࡟࡞ࡗࡓࠋ2005 ᖺ࡟ึ௦࢘ࢪࣙ࢘ࣂ࢚ࡢ᫬ィ㑇ఏᏊࡀⓎぢࡉࢀ 15ࠊ⏕≀᫬ィࡀᇵ㣴⫢⣽⬊ࡀ⏕ࡁ࡚࠸ࡓࡽ้ࢇࡔࡣࡎࡢ⫢⮚ࡢࣜࢬ㑇ఏᏊ࡟᭩࠿ࢀࡓ᝟ሗ࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡾࣀ࣮࣋ࣝ

࣒ࢆグ᠈ࡋ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡗࡓ 24ࠋࡉࡽ࡟ 2012 ᖺ㈹࡟ࡘ࡞ࡀࡗࡓࠋࡑࡢ㛫ࠊ1994 ᖺ࡟ࡣ᪥ᮏ᫬㛫⏕≀࡟⫢⣽⬊ࢆࠊᮏ᮶ࡢᙧែ࡜␗࡞ࡿⷧࡃᡥᖹ࡞༢ᒙ࡛ᇵᏛ఍ࡀタ❧ࡉࢀࡓࠋ1997 ᖺ࡟࣐࢘ࢫ Period ࡜࡜ࡶ࡟㣴ࡍࡿ࡜ࣜࢬ࣒ࡀࡍࡄ࡟ᾘኻࡋ࡚ࡋࡲ࠺ࡀࠊ3 ḟඖᇵClock ࡀࢡ࣮ࣟࢽࣥࢢࡉࢀࠊE-box ࡬⤖ྜࡍࡿ Clock-㣴ࡍࡿ࡜㛗ᮇ࡟᫬ィࡀᅇࡿࡇ࡜ࡀࢃ࠿ࡗࡓ 25ࠋ࢖ࣥࢫ

Bmal1 ࡟ࡼࡿ㌿෗ࡢࢿ࢞ࢸ࢕ࣈ࣭ࣇ࢕࣮ࢻࣂࢵࢡไ

ࣜࣥࡸ࠸ࡃࡘ࠿ࡢࢳࣟࢩࣥࣜࣥ㓟໬ࢆ௓ࡍࡿࢧ࢖ࢺ␗యࡀⓎぢࡉࢀࡓ 14ࠋ1984 ᖺ࡟ࡣ

᫬㛫⏕≀Ꮫ
22

Vol. 26, No. 1 (2020)ᅗ 1 24 ᫬㛫᫬ィ࡛⾲ࡋࡓ⏕⌮ᶵ⬟ࡸ⑌ᝈࡢ㉳ࡁࡸࡍ࠸᫬㛫ᖏࡢᴫ␎ᅗ
⏕⌮⌧㇟ࡔࡅ࡛࡞ࡃࠊ⑌ᝈࡢⓎ⑕ࡸṚஸࡍࡿ᫬㛫ᖏࡶᴫ᪥᫬ィ࡟ࡼࡗ࡚ไᚚࢆཷࡅ࡚࠸ࡿࠋ࣍ࣝࣔࣥࢆᅄゅ࡛ᅖࡳࠊ⑌ᝈࢆᴃ෇
࡛ᅖࢇࡔࠋ࢝࢖ࣥ࡟⫢⣽⬊ࡢ᫬ィ㑇ఏᏊࢆື࠿ࡍస⏝ࡀぢࡘ࠿࠼ࡤኪ୰࡟ᡂ㛗࣍ࣝࣔࣥࡢศἪࡀከ࠸ࡇ࡜ࡀ▱ࡽࢀ

ࡗࡓ 25ࠋ2000 ᖺ࡟ࡣᦤ㣗ࡣࠊ⬻ࡢど஺ཫୖ᰾㸦SCN㸧

࡚࠸ࡿࠋ୍᪉ࠊࠕ㨱ࡢ᫬㛫ࠖ࡜࠸ࢃࢀࡿ✺↛Ṛࡀከ࠸ࡢྠㄪస⏝ࢆ♧ࡉ࡞࠸ࡶࡢࡢࠊᮎᲈ⤌⧊ࡢ᫬ィࡢᙉ࠸᫬㛫ᖏࡀᏑᅾࡍࡿ 28ࠋ㢧ⴭ࡞ࡢࡀ༗๓୰࡜ኤ᪉࡟࠶ࡗ

ྠㄪᅉᏊ࡛࠶ࡿࡇ࡜ࡀ♧ࡉࢀࡓ 26ࠋ⚾ࡓࡕࡶࠊྠ᫬ᮇ

࡚ࠊ≉࡟༗๓ࡢ᫬㛫ᖏࡣᚰ➽᱾ሰࠊ⬻᱾ሰ࡞࡝ࡀ㉳ࡁ࡟⫢⣽⬊ࡢ᫬㛫ⓗ࣭ᰤ㣴Ꮫⓗไᚚࡢ㔜せᛶ࡟Ẽ௜ࡃࡼࡸࡍ࠸⏕⌮⌧㇟ࡀ㞟୰ࡍࡿࡲࡉ࡟㨱ࡢ᫬㛫࡛࠶ࡿࠋ⫶࠺࡟࡞ࡾࠊᦤ㣗ࢱ࢖࣑ࣥࢢࢆไᚚࡉࡏࡿᐇ㦂࡟⯦ࢆษ₽⒆ࡀࡦ࡝ࡃ࡞ࡿ᫬㛫ᖏࡀ᪩ᮅ࡛࠶ࡿ࡜࠿ࠊ⑓Ẽࡢ㉳ࡗࡓࠋࡑࡋ࡚ࠊ2005 ᖺ࡟ࡣࠊ⚾ࡓࡕࡀ⦅㞟ࡋࡓᰤ㣴ࡁࡿ᫬㛫ᖏࡔࡅ࡛࡞ࡃࠊṚࡠ᫬㛫࡟ࡶṚᅉ࡟ࡼࡾ᪥࿘

Ꮫࡢࢸ࢟ࢫࢺ࡛ 2005 ᖺึࡵ࡚ࠊ᫬㛫ᰤ㣴Ꮫ࡜࠸࠺㡯ࣜࢬ࣒ࡀ࠶ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ㸦ᅗ 1㸧ࠋ⢭⚄ⓗࠊ㌟┠ࢆసࡗࡓ 27ࠋࡶࡕࢁࢇⴭ⪅௨እ࡟ࡶከࡃࡢ◊✲⪅ࡀయⓗ࡟ࣃࣇ࢛࣮࣐ࣥࢫࡢ㧗ࡃ࡞ࡿ᫬㛫ᖏࡶ▱ࡽࢀ࡚㣗஦ࡢࢱ࢖࣑ࣥࢢࡢ㔜せᛶ࡟Ẽ࡙࠸࡚◊✲ࢆ㛤ጞࡋ࠸࡚ 29ࠊࡑࡢࡏ࠸ࡶ࠶ࡗ࡚࠿᫇࠿ࡽ࢜ࣜࣥࣆࢵࢡࡢỴ࡚࠸ࡓࠋࡑࡋ࡚ࠊ2008 ᖺ࡟㤶ᕝࡀ᪥ᮏᰤ㣴࣭㣗⣊Ꮫ຾ࡀ༗ᚋ࡟⾜ࢃࢀࡿࡇ࡜ࡀከ࠸ࠋ᝿ീࡋ࡚࠸ࡿࡼࡾ

఍ࡢ኱఍࡛ࢩ࣏ࣥࢪ࣒࢘ࢆ௻⏬ࡋࠊࡇࡢࢩ࣏ࣥࢪ࣒࢘

ࡶࠊࡣࡿ࠿࡟⚾ࡓࡕࡢయࡣ᫬㛫㸦ෆᅾⓗ࡞ᴫ᪥᫬ィ㸧

ࢆᇶ࡟ 2009 ᖺ࡟ࡣୡ⏺࡛᭱ึࡢࠗ᫬㛫ᰤ㣴Ꮫ࠘࡜㢟࡟ไᚚࡉࢀ࡚࠸ࡿࡇ࡜ࡀࡼࡃࢃ࠿ࡿࠋ

ࡍࡿᮏࡀฟ∧ࡉࢀࡓ 5ࠋ2014 ᖺ࡟ࡣᰘ⏣ࡀ୰ᚰ࡟࡞ࡗ

⏕≀ࡀෆᅾⓗ᫬ィ㸦ᴫ᪥᫬ィ㸧ࢆᣢࡓ࡞ࡅࢀࡤ࡞ࡽ

࡚᫬㛫ᰤ㣴Ꮫ◊✲఍ࢆ❧ࡕୖࡆࠊᰘ⏣ࡢᑾຊ࡟ࡼࡾ

࡞࠸⌮⏤࡜ࡋ࡚ 2 ࡘࡢࡇ࡜ࡀ⪃࠼ࡽࢀࡿࠋ
ࠕᮍ᮶ண

2020 ᖺ࡟᪥ᮏ᫬㛫ᰤ㣴Ꮫ఍࡬Ⓨᒎࡍࡿࡇ࡜࡟࡞ࡗ

ᛶࠖ࡜ࠕᶵ⬟ⓗศᴗ࡛ࠖ࠶ࡿࠋ
ࠕᮍ᮶ணࡓࠋ᫬㛫ᰤ㣴Ꮫࡣࠊ㏆ᖺᛴ⃭࡟ᾐ㏱ࡍࡿࡼ࠺࡟࡞ࡾࠊ

ࡢ⋓ᚓ࡜ᤕ㣗࠿ࡽ㏨ࢀࡿࡓࡵ࡟࡞ࡃ࡚࡞ࡽ࡞࠸ᶵ⬟᪥ᮏேࡢ㣗஦ᦤྲྀᇶ‽࡛ࡶྲྀࡾୖࡆࡽࢀࡿࡼ࠺࡟࡞

࡛࠶ࡿࠋ့ங㢮ࡣࠊᜍ❳ࡀఇࢇ࡛࠸ࡿኪ࡟άືࡋ࡚࠸

ࡗࡓࠋࡇࡢ᫬㛫ᰤ㣴Ꮫࡀࠊ࢚ࢿࣝࢠ࣮ᦤྲྀࡀῶࡗ࡚࠸

ࡓࡓࡵࠊከࡃࡢ့ங㢮ࡣ࠸ࡲ࡛ࡶኪ⾜ᛶ࡛࠶ࡿࠋᜍ❳ࡿ࡟ࡶ࠿࠿ࢃࡽࡎቑ࠼ࡿ⫧‶ࡸ࣓ࢱ࣎ࡢㅦࢆゎࡃ࢝ࡀ࠸࡞ࡃ࡞ࡾࠊ୍㒊ࡢࡶࡢࡔࡅࡀ㣵ࡢ⋓ᚓ࡟᭷฼࡞᫨

ࢠ࡜ࡋ࡚ࢡ࣮ࣟࢬ࢔ࢵࣉࡉࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁࡓࠋ

㛫࡟άືࡍࡿࡼ࠺࡟࡞ࡗࡓ࡜⪃࠼ࡽࢀࡿࠋࠕᶵ⬟ⓗศᛶࠖࡣ୺࡟㣵

ᴗࠖࡣࠊከࡃࡢ」㞧࡞⣽⬊ᶵ⬟ࡢ᫬㛫ⓗศᴗࢆྍ⬟࡟
4. ᫬ィ㑇ఏᏊ࡜௦ㅰ
⚾ࡓࡕࡢయࡢ୰࡟ࡣࠊከࡃࡢ᪥࿘ࣜࢬ࣒ࡀ࠶ࡾࠊ౛᫬㛫⏕≀Ꮫࡍࡿస⏝࡛࠶ࡿࠋ⣽⬊ቑṪࡣ୍⯡࡟ගࡢᑡ࡞࠸ኪ࡟⾜ࢃࢀ 30ࠊ᫨ࡣάື࡟ᚲせ࡞ศ໬ᶵ⬟ࡀ⾜ࢃࢀࡿࠋከࡃ

Vol. 26, No. 1 (2020)23

ᅗ 2 㣗஦ࡣᮎᲈ⮚ჾࡢᙉ࠸ྠㄪᅉᏊ࡜ࡋ࡚ാࡃ
ど஺ཫୖ᰾(SCN) ࡢ࣐ࢫࢱ࣮᫬ィࡣࠊගࡔࡅ࡟ࡼࡗ࡚ྠㄪࢆཷࡅࡿࡀࠊᮎᲈ⤌⧊ࡢ᫬ィࡣ㣗஦࡟ࡼࡗ࡚ྠㄪࢆཷࡅࡿࠋ⬻ࡢ୍㒊ࡶ㣗஦࡟ࡼࡾྠㄪࢆཷࡅࡿࠋ

ࡢ⏕໬Ꮫⓗ௦ㅰ⤒㊰ࡣࠊከࡃࢆ௚ࡢ௦ㅰ⣔࡜ඹ㏻࡟ࡋ

25,26ࠋᴫ᪥᫬ィࡀᏑᅾࡍࡿ⌮⏤ࡀࢱ࢖࣒࣮ࣜ࡟㣗≀ࢆ࡚࠸ࡿࠋ᫬㛫ⓗศᴗࢆ⾜ࢃ࡞࠸࡜௦ㅰࡣࢫ࣒࣮ࢬ࡟ὶ

ᚓࡿࡇ࡜࡟࠶ࡗࡓⅬࢆ⪃࠼ࡿ࡜ࠊࡇࢀࡣྜ⌮ⓗ࡞ᛂ⟅ࢀࡿࡇ࡜ࡀ࡛ࡁ࡞ࡃ࡞ࡿࠋ౛࠼ࡤࠊ⢾᪂⏕࡜ゎ⢾⣔ࡀ࡛࠶ࡿࠋኴ㝧ගࢆ࣮࣌ࢫ࣓࣮࣮࢝࡟౑ࡗ࡚࠸ࡓࡢࡣࠊ

ྠ᫬࡟ືࡃ࡜࠸࠺ࡇ࡜ࡣ࠶ࡾ࠼ࡎࠊ௦ㅰⓗ▩┪ࢆᅇ㑊㣗஦ࢆ࡜ࡿ᫬㛫ࢆྜࢃࡏࡿࡢ࡟ᚲせࡔࡗࡓ࠿ࡽ࡛࠶

ࡍࡿࡓࡵ࡟ࠊ᫬㛫ⓗᶵ⬟ศᴗࡣᚲ㡲ࡢᶵ⬟࡛࠶ࡿࠋࡾࠊ㔜せ࡞ࡢࡣ㣗஦࡛࠶ࡗࡓࠋࡉࡽ࡟ࠊ୍㒊ࡢ◊✲࡛⏕≀᫬ィࡢ◊✲ࡣࠊࡣࡌࡵ⬻ࡢ᫬ィ࡟ὀ┠ࡋ࡚㐍ࡵࡣࠊ㣗஦ࡀ SCN ௨እࡢ⬻ࡢ᫬ィࡶྠㄪࡉࡏࡿࡇ࡜ࡀ

ࡽࢀࠊSCN ࡟࣐ࢫࢱ࣮᫬ィࡀ࠶ࡿࡇ࡜ࡀゎ᫂ࡉࢀࡓࠋ

ሗ࿌ࡉࢀ࡚࠸ࡿ 32ࠋࡑࡋ࡚⮬ᚊⓗ࡟ᙉ࠸ 24 ᫬㛫ࡢ᣺ືࢆ♧ࡋ࡚࠸ࡿࠋࡑ

㑇ఏᏊ࡛ࣞ࣋ࣝㄪ࡭ࡿ࡜ࠊ⫢⮚࣭ᚰ⮚࣭኱⭠࡞࡝࡯ࡢ⤖ᯝࠊయࡢ᫬ィࡣࠊගࡢ่⃭ࢆཷࡅࡓ SCN ᫬ィࡀ࡜ࢇ࡝ࡢ⮚ჾ࡛ 10 %࡯࡝ࡢ㑇ఏᏊࡣࣜࢬ࣒ࢆ้ࢇ࡛

య඲యࢆไᚚࡋ࡚࠸ࡿ࡜⌮ゎࡉࢀࡿࡼ࠺࡟࡞ࡗࡓࠋࡋ

࠸ࡿ 33-35ࠋྠࡌ㑇ఏᏊ࡛ࡶ⮚ჾࡈ࡜࡟ࡑࡢࣆ࣮ࢡ᫬㛫࠿ࡋࠊᮎᲈࡢ⣽⬊࡛ࡶ᫬ィࢆᣢࡗ࡚࠸ࡿࡇ࡜ࡀศ࠿

ࡣ␗࡞ࡾࠊ⮚ჾ⊂⮬ࡢ᫬ィࡀᅇࡗ࡚࠸ࡿࡇ࡜ࡀࢃ࠿

ࡾࠊ⌧ᅾ࡛ࡣࡍ࡭࡚ࡢ⣽⬊ࡀ⊂⮬ࡢ 24 ᫬㛫ࡢ᫬ィࢆࡿࠋࡑࡋ࡚ࠊࡑࢀࡒࢀࡢ⮚ჾ᫬ィࡀ༠ㄪⓗ࡞ࢿࢵࢺ࣡

ᣢࡗ࡚࠸࡚ࠊࡑࢀࡀ⮚ჾࡢ᫬ィ࡜࡞ࡾࠊ⮚ჾ㛫ࢆྠㄪ࣮ࢡࢆసࡾࢡࣟࢫࢺ࣮ࢡࡋ࡚࠸ࡿ≧ែࡀ೺ᗣ࡞≧ែࡉࡏࡿᅉᏊࢆ௓ࡋ࡚⤫ྜⓗ࡞᫬ィࢆᙧᡂࡋ࡚࠸ࡿ࡜

࡜⪃࠼ࡽࢀࡿࠋෆ⮚࡟ᑐࡍࡿᙉ࠸ྠㄪᅉᏊࡀ㣗஦࡛࠶ゎࡉࢀ࡚࠸ࡿ 31ࠋࡋࡓࡀࡗ࡚ࠊ㔜せ࡞ࡢࡣྠㄪᅉᏊ࡛

ࡿ࡜㏙࡭࡚ࡁࡓࡀࠊᬑ㏻ࡢ⏕ά࡛ࡣࠊኴ㝧ග࡟ྜࢃࡏ

࠶ࡿࠋ㏻ᖖࠊኴ㝧ග࡟ࡼࡾྠㄪࢆཷࡅࡓ⬻᫬ィࡀ⮬ᚊ࡚つ๎ṇࡋ࠸㣗஦ࢆ࡜ࡗ࡚࠸ࡿ㝈ࡾయࡢ᫬ィࡣኴ㝧⚄⤒⣔ࡸෆศἪ⣔ࢆ௓ࡋ࡚ᮎᲈ⤌⧊ࢆไᚚࡋࠊࡑࢀ࡟

ࡢග࡟ྠㄪࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊ⌧௦♫఍࡛ࡣࠊࡑࡢࡼ

ࡼࡗ࡚య඲యࡢ᫬ィࡀ⤫ᚚࡉࢀࡿࠋࡘࡲࡾࠊගࡀ᭱ࡶ

࠺࡞⏕άࢆࡍࡿࡢࡀᅔ㞴࡞ேࡀከࡃ࡞ࡗ࡚ࡁ࡚࠸ࡿࠋ

ᙉ࠸ྠㄪᅉᏊ࡛࠶ࡿࠋ

ඛ࡟㏙࡭ࡓື≀ᐇ㦂࡛⾜ࢃࢀࡓࡼ࠺࡞ࠊᦤ㣗ࢱ࢖࣑ࣥ࡜ࡇࢁࡀࠊᦤ㣗ࢱ࢖࣑ࣥࢢࢆ㏫㌿ࡉࡏࡿ࡜ᾘ໬ჾ⣔ࡢࣜࢬ࣒ࡀ㏫㌿ࡋ࡚ࡃࡿࡇ࡜ࡀศ࠿ࡾࠊᾘ໬ჾ⣔ࡢ᫬

ࢢࢆ㏫㌿ࡉࡏࡓࡼ࠺࡞㣗⏕άࢆࡋ࡚࠸ࡿேࡀከࡃ࡞
ࡗ࡚࠸ࡿࠋィࡢྠㄪᅉᏊࡣගࡢไᚚࡼࡾ㣗஦ࡢ᪉ࡀᙉ࠸ࡇ࡜ࡀ

᫬ィ㑇ఏᏊࡢࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆ౑ࡗࡓᐇ㦂ࡣࠊࢃ࠿ࡗࡓ 26ࠋ㣗஦ࡣෆ⮚࡟࠾࠸࡚᭱ࡶᙉ࠸ྠㄪᅉᏊ࡛

᫬ィ㑇ఏᏊࡢḞᦆࡀ⾜ື␗ᖖࢆ㉳ࡇࡍࡇ࡜ࢆ♧ࡋࡓࠋ࠶ࡿࡇ࡜ࡀ⌮ゎࡉࢀࡿࡼ࠺࡟࡞ࡗࡓ㸦ᅗ 2㸧ࠋᑡ࡞ࡃࡑࢀࡔࡅ࡛࡞ࡃࠊ᫬ィ㑇ఏᏊࡢḞᦆࡀ௦ㅰ␗ᖖࢆᑟࡃ

࡜ࡶ㤳࠿ࡽୗࡢ኱㒊ศࡢ⮚ჾࡢ᫬ィࡢྠㄪᅉᏊࡣ㣗ࡇ࡜ぢࡘ࠿ࡗࡓࠋ2005 ᖺ࡟Ⓨ⾲ࡉࢀࡓ Clock ኚ␗࣐஦࡜࠸ࡗ࡚ࡶᕪࡋᨭ࠼࡞࠸࡯࡝࡛࠶ࡿࠋලయⓗ࡟ࡣࠊ࢘ࢫࡀ⫧‶࡜࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࢆ㉳ࡇࡍ࡜⫢⮚ࠊ⭈⮚ࠊᚰ⮚ࠊ⮅⮚ࠊ⬡⫫⤌⧊ࠊ➽⫗࡞࡝࡛࠶ࡿ

࠸࠺ሗ࿌ࡣ኱ࡁ࡞ὀ┠ࢆᾎࡧࡓ 36ࠋࡉࡽ࡟ Bmal1 ࡀ

᫬㛫⏕≀Ꮫ
24

Vol. 26, No. 1 (2020)⫧‶࡟㔜せ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓ 37,38ࠋᙜึ᝿ึࡢ◊✲࡛࠶ࡿࠋࡇࢀࡣࠊ᫬ィ㑇ఏᏊࢆࡣࡌࡵࢥࣞࢫ

ീࡉࢀ࡚࠸ࡓࣜࢬ࣒␗ᖖࡔࡅ࡛࡞ࡃࠊࣀࢵࢡ࢔࢘ࢺ࣐

ࢸ࣮ࣟࣝࡢ␗໬௦ㅰࠊࡘࡲࡾ⫹Ồ㓟ྜᡂࡢᚊ㏿㓝⣲࢘ࢫ࡟࠾࠸࡚ࡳࡽࢀࡓ௦ㅰ␗ᖖࡣࠊᴫ᪥᫬ィ࡜ᮎᲈࡢCYP7A1 ࡢ㑇ఏᏊⓎ⌧ࡢᴫ᪥ࣜࢬ࣒ࡢࣆ࣮ࢡ㸦఩┦㸧௦ㅰࡀᙉࡃ⤖ࡧࡘ࠸࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ

ࡀ๓࡟ࡎࢀࡓࡓࡵ࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ

ࣄࢺ࡛ࡣࠊPER2 ࡢ㑇ఏᏊኚ␗࡟ࡼࡾ㑇ఏⓗ᪩㉳ࡁࡇࡢ◊✲࡟࠾࠸࡚ࠊ⫢⮚࠿ࡽศἪࡉࢀࡿ࢔ࣝࣈ࣑ࣥ

⑕ೃ⩌ࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀ 39ࠊ௦ㅰ␗ᖖࢆక࠺᫬ィ㑇ࡸ࢔࣏࣏ࣜࢱࣥࣃࢡ㉁ A-I㸦Apo A-I㸧ࡀ㌿෗࡟ࣜࢬ࣒

ఏᏊࡢኚ␗ࡣሗ࿌ࡉࢀ࡚࠸࡞࠸ࠋࣄࢺ࡛㔜⠜࡞᫬ィ㑇ࡀ࠶ࡿࡶࡢࡢࠊmRNA ࡟ࣜࢬ࣒ࡀ࡞࠸ࡇ࡜ࢆぢฟࡋఏᏊࡢኚ␗ࡀぢࡘ࠿ࡗ࡚࠸࡞࠸ࡇ࡜ࡣࠊ᫬ィ㑇ఏᏊࡀ

ࡓࠋmRNA ࡢ༙ῶᮇࡀ㛗࠸ࡓࡵࠊ㌿෗ࣞ࣋ࣝࡢࣜࢬ

⏕Ꮡ࡟࡜ࡗ࡚ᚲ㡲࡞せ⣲࡛࠶ࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋࡍ

࣒ࡀ mRNA ࡟཯ᫎࡉࢀ࡞࠸ࠋࡑࡋ࡚ࠊࡑࡢ㌿෗ࣜࢬ

࡛࡟㏙࡭ࡓࡼ࠺࡟ࠊࢩࣇࢺ࣮࣮࣡࢝࡞࡝୙つ๎࡞㣗⏕࣒ࡣࢲࣛࢲࣛ㣗࠸࡟ࡼࡗ࡚ኻࢃࢀ࡚ࡋࡲࡗࡓࠋ⾑Ύ࢔άࢆࡍࡿே࡟⑌ᝈࡀከ࠸ࠋ୙つ๎࡞⏕άࠊ㣗⏕άࡣࡑࣝࣈ࣑ࣥࡢ⥔ᣢࡣ㧗㱋⪅࡟࡜ࡗ࡚㔜せ࡛࠶ࡾࠊApo A-ࢀ⮬యࡀᵝࠎ࡞⑌ᝈⓎ⑕ࢆ᪩ࡵ࡚࠸ࡿࠋࡋ࠿ࡋࠊࡑࡢ

I ࡣ HDL㸦㧗ᐦᗘ࣏ࣜࢱࣥࣃࢡ㉁㸧ࡢ୺せ࢔࣏࣏ࣜࢱ

࣓࢝ࢽࢬ࣒ࡀ᫂ࡽ࠿࡟ࡉࢀ࡚࠸࡞࠸ࡓࡵࠊ⏕≀᫬ィࡢࣥࣃࢡ㉁࡛࠶ࡿࠋ࡞ࡐࡑࡢࡼ࠺࡞ከ኱࡞ປຊࢆᡶࡗ࡚㔜せᛶ࡟་⒪㛵ಀ⪅ࡶ༑ศ࡟ὀពࢆᡶࡗ࡚࠸࡞࠸≧ࡲ࡛㌿෗ࣜࢬ࣒ࢆ⥔ᣢࡋ࡚࠸ࡿࡢ࠿ࠋ㣗஦ࡢࢱ࢖࣑ࣥ

ἣ࡛࠶ࡗࡓࠋ

ࢢ࡟ࡼࡗ࡚㌿෗ࡢࣜࢬ࣒ࢆ㛗ᮇ࡟⥔ᣢࡍࡿࡇ࡜ࡀࠊ⾑Ύ⃰ᗘࡢ⥔ᣢࠊࡲࡓࡣ೺ᗣࡢ⤖ࡧࡘࡃྍ⬟ᛶࡀ࠶ࡿࠋ

5. ୙つ๎࡞ᦤ㣗ࢱ࢖࣑ࣥࢢ࡜⬡㉁௦ㅰ␗ᖖ
⫢⮚ࢆࡣࡌࡵ࡜ࡍࡿᾘ໬ჾ⣔ࡢ᫬ィࡣ㣗஦ࢱ࢖࣑(2) ኪ㣗⑕ೃ⩌ࣥࢢࡢᙳ㡪ࢆ┤᥋ཷࡅࠊᾘ໬ჾ⣔ࡢ᫬ィࡢ␗ᖖࡣ௦ㅰ

ኪ㛫ࡔࡅ㣗࡭ࡿࡇ࡜࡛⫧‶࡟࡞ࡿኪ㣗⑕ೃ⩌࡜࠸␗ᖖ࡟⤖ࡧࡘࡃ 6,7ࠋ㣗஦ࢱ࢖࣑ࣥࢢࡣ᫬ィ㑇ఏᏊࡢⓎࢃࢀࡿ⌧㇟ࡀ▱ࡽࢀ࡚࠸ࡿ 40ࠋື≀ࡢ㣗஦ࢱ࢖࣑ࣥࢢ

⌧ࢆኚືࡉࡏࡿࡇ࡜࡛௦ㅰ␗ᖖࢆᘬࡁ㉳ࡇࡋࠊ⫧‶ࡸ

ࢆ㏫㌿ࡉࡏࡿ࡜ࠊ᫬ィ㑇ఏᏊࡣ᏶඲࡟㏫㌿ࡍࡿࡇ࡜ࡣ

࣓ࢱ࣎࡟ࡘ࡞ࡀࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋྠㄪᅉᏊࡢࡎࢀ

ࡍ࡛࡟㏙࡭࡚ࡁࡓࠋ࡜ࡇࢁࡀࠊ⫢⮚ࡢ⬡㉁௦ㅰࡢ㑇ఏ࡟ࡼࡿࣜࢬ࣒ࡢ఩┦ࡢࡎࢀࡀ㔜኱࡞⏕໬Ꮫⓗ࣭⏕⌮ᏛᏊⓎ⌧ࣜࢬ࣒ࡣ᏶඲࡟㏫㌿ࡍࡿࡇ࡜ࡣ࡞ࡃࠊ⾑୰ࢥࣞⓗᙳ㡪ࢆ୚࠼ࡿࠋࡇࢀࡣྠㄪᅉᏊࡢࢱ࢖࣑ࣥࢢࡢ㔜せࢫࢸ࣮ࣟࣝࡀቑຍࡍࡿࡇ࡜ࢆぢฟࡋࡓ㸦ᮍⓎ⾲㸧ࠋᛶࢆ♧ࡍࡶࡢ࡛࠶ࡿࠋ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡣࠊ⬡㉁௦ㅰ␗ᖖ࡟ጞࡲࡾࠊ࢖ࣥࢫࣜࣥ᢬ᢠᛶࢆᇶ┙࡜ࡍ(3) ᮅ㣗Ḟ㣗ࡿᮍ⑓(๓⑌ᝈ)≧ែࢆᣦࡍࠋ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮ࣟ

ඛ㐍ᅜ࡛ࡣࠊⱝ࠸ேࡓࡕࡢ࠾ࡼࡑ 30 %ࡀᮅ㣗ࢆࡕ࣒ࡢண㜵ࡣࠊ᭱⤊ⓗ࡟ື⬦◳໬⑕ࡢண㜵ࢆ┠ᣦࡍࡶࡢࡷࢇ࡜࡜ࡗ࡚࠸࡞࠸ࠋᮅ㣗Ḟ㣗ࡣࠊほᐹ◊✲࠿ࡽ⫧‶࡛࠶ࡾࠊ⑓ែ࡟࠾࠸࡚ࡶ⾑Ύ࣏ࣜࢱࣥࣃࢡ㉁௦ㅰࢆࡣ

࡟࡞ࡾࡸࡍ࠸ࡇ࡜ࡀሗ࿌ࡉࢀ࡚ࡁࡓ 41ࠋࡑࡋ࡚ࡇࢀࡀ

ࡌࡵ⬡㉁௦ㅰࡢᨵၿࢆ┠ᣦࡍࡶࡢ࡛࠶ࡿࠋ⫧‶࡞࡝ࡢ㛗ࡃ⥆࠸ࡓሙྜࠊ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡸ 2 ᆺ⢾⬡㉁௦ㅰࡢ␗ᖖࡣࠊ」ᩘࡢࡀࢇ࡜㛵㐃ࡍࡿࡇ࡜ࡶ᫂ࡽ

ᒀ⑓࡟⤖ࡧࡘࡃྍ⬟ᛶࡀ▱ࡽࢀࡿࡼ࠺࡟࡞ࡗࡓࠋࡋ࠿

࠿࡟ࡉࢀ࡚࠸ࡿࠋከࡃࡢ⏕ά⩦័⑓ࡢ⿬࡟ࡣࠊ⬡㉁௦

ࡋࠊࡑࡢ࣓࢝ࢽࢬ࣒ࡀ༑ศ࡟ゎ᫂ࡉࢀ࡚࠾ࡽࡎࠊࡇࢀ

ㅰࡢ␗ᖖࡀ࠶ࡿࠋࡑࡇ࡛ࠊ⚾ࡓࡕࡣ㑇ఏⓗᨵኚࢆࡋ࡚

ࡲ࡛ᮅ㣗ࡢ㔜せᛶ࡜ࡋ࡚ࠊ౛࠼ࡤ⾑⢾್ࢆቑຍࡉࡏࡿ

࠸࡞࠸ື≀ࢆ⏝࠸࡚ࠊᵝࠎ࡞୙つ๎࡞㣗஦ࢱ࢖࣑ࣥࢢ

ࡓࡵ࡜࠿ࠊࢭ࢝ࣥࢻ࣑࣮ࣝຠᯝ࡞࡝ࡀ࠶ࡆࡽࢀ࡚࠸

࡟ࡼࡗ࡚యෆ᫬ィࢆ஘ࡍᐇ㦂ࢆ⾜࠸ࠊ⬡㉁௦ㅰ࡟ཬࡰ

ࡿࠋࢭ࢝ࣥࢻ࣑࣮ࣝຠᯝࡣࠊᮅ㣗ࢆ㣗࡭ࡿ࡜ࡑࢀ௨㝆ࡍᙳ㡪ࢆ᳨ウࡋࡓࠋࡢ㣗ᚋ⾑⢾್ࡢቑຍࡀᢚ࠼ࡽࢀࡿ⌧㇟࡛࠶ࡿࠋ
⚾ࡓࡕࡣࠊᮅ㣗࡟ᙉ࠸యෆ᫬ィྠㄪస⏝ࡀ࠶ࡿࡇ࡜

(1) ࢲࣛࢲࣛ㣗࠸㸦᫨ኪࡢ࣓ࣜࣁࣜࡢ࡞࠸㣗⏕ά㸧࠿ࡽࠊᮅ㣗Ḟ㣗ࡣయෆ᫬ィࡢࢬࣞࢆ௓ࡋ࡚⬡㉁௦ㅰ࡟

ኪ⾜ᛶࡢࣛࢵࢺ࡟ไ㝈⤥㣵ࠊ౛࠼ࡤ᫨ࡔࡅ⤥㣵ࡉࡏᰤ㣴ࢆཬࡰࡋ࡚࠸ࡿࡢ࡛ࡣ࡞࠸࡜⪃࠼ࡓࠋࣛࢵࢺࡢά

ࡿ࡜ࠊ⫢⮚᫬ィࡣ᫨ኪ㏫㌿ࡍࡿࡀࠊࡋࡤࡽࡃࡍࡿ࡜ࡑ

ືᮇࡢ᭱ึ࡟㣗࡭ࡿ㣗஦ࢆᩘ᫬㛫㐜ࡽࡏࡿ࡜ࠊయෆ᫬

ࢀ࡟࡞ࢀ࡚ࡋࡲ࠺ࠋ୙つ๎࡞㣗⏕άࢆࡉࡏࡿࡓࡵࠊ᫨

ィ࡟ࢬࣞࡀ⏕ࡌࠊ⬡㉁௦ㅰࡢ஘ࢀࢆ௓ࡋ࡚య㔜ቑຍࢆኪࡢ༊ู࡞ࡃࢲࣛࢲࣛ㣗࡭ࡿ⤥㣵ࣉࣟࢺࢥ࣮ࣝࢆ⪃ࡶࡓࡽࡍࡇ࡜ࢆ♧ࡋࡓ 7ࠋᮅ㣗ࡣࠊⱥㄒ࡛ breakfast᱌ࡋࡓࠋࢲࣛࢲࣛ㣗࠸࡛ࡣ⫢⮚ࡢᴫ᪥᫬ィ࡟␗ᖖࡀ⏕࡛࠶ࡿࡼ࠺࡟ࠊ㛗ᮇࡢ⤯㣗ᚋࡢ᭱ึࡢ㣗஦࡛࠶ࡿࡇ࡜

ࡌࠊ⾑୰ࢥࣞࢫࢸ࣮ࣟࣝ㸦୺࡟ VLDL㸧ࡀୖ᪼ࡋࡓ㸦ࣛࡀయෆ᫬ィࢆྠㄪࡉࡏࡿస⏝࡜ࡋ࡚㔜せ࡛࠶ࡿࠋᮅ㣗ࢵࢺ࡟ࡣ LDL ࡀ࡞࠸㸧6ࠋ୙つ๎࡞㣗஦ࢱ࢖࣑ࣥࢢࡔ

Ḟ㣗ࡣࠊ⫢⮚࡞࡝ࡢ௦ㅰࡢ᫬ィࡸయࡅ࡛⬡㉁௦ㅰࢆ␗ᖖ࡟ࡍࡿࡇ࡜ࢆᐇ㦂ⓗ࡟♧ࡋࡓ᭱ᘬࡁ㉳ࡇࡋࠊኴࡾࡸࡍ࠸య㉁ࢆసࡗ࡚࠸ࡿࠋࡲࡓࠊࣄ᫬㛫⏕≀Ꮫࡢ᫬ィࡢኚືࢆ

Vol. 26, No. 1 (2020)25ࢺࡢᐇ㦂࡛ࡶࠊᮅ㣗ࢆ 5 ᫬㛫ࡎࡽࡋࡓሙྜ࡟⬡⫫⤌⧊(2) ≀⌮ⓗ่⃭ࡢ᫬ィࡀ㐜ࢀࡿࡇ࡜ࡀ♧ࡉࢀ 42ࠊࣄࢺ࡛ࡶᮅ㣗Ḟ㣗ࡣ୍᪉ࠊࡇࡢࡼ࠺࡟ᰤ㣴⣲ࡀయࡢ୰࡟ධࡗ࡚ຠࡃ࡜⪃యෆ᫬ィࡢࢬࣞࢆ㉳ࡇࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗ

࠼ࡽࢀ࡚࠸ࡿࡀࠊ⤒ཱྀᦤྲྀ࡟ࡼࡗ࡚㣗≀ࡀᾘ໬ჾ⣔ࢆࡓࠋ≀⌮ⓗ࡟่⃭ࡍࡿࡇ࡜࡟ࡼࡿྠㄪࡶ▱ࡽࢀ࡚࠸ࡿࠋ๪⭈⓶㉁࠿ࡽศἪࡉࢀࡿࢢࣝࢥࢥࣝࢳࢥ࢖ࢻ࣍ࣝࣔࣥ

(4) ᫬㛫ไ㝈ᦤ㣗ࡣࠊάືᮇࡢ┤๓࠿ࡽࡑࡢ⃰ᗘࡀ㧗ࡃ࡞ࡿᴫ᪥ࣜࢬ࣒

つ๎ṇࡋ࠸㣗⏕άࢆࡉࡏࡿ࡜⬡㉁௦ㅰࡣṇᖖ໬ࡉࢆ้ࢇ࡛࠸ࡿࠋᰤ㣴⣲ࢆ⤒ཱྀⓗ࡟ᢞ୚ࡍࡿሙྜ࡜ࠊ㠀ࢀࡿࡢ࡛࠶ࢁ࠺࠿ࠋ⮬⏤ᦤ㣗ࡉࡏࡓ࣐࢘ࢫࠊࣛࢵࢺࡣ

⤒ཱྀⓗ㸦⭠⟶ࢆ௓ࡉࡎ㸧࡟ᢞ୚ࡍࡿሙྜࢆẚ㍑ࡍࡿ࡜ࠊ

8 ๭ࡢ㣵ࢆάືᮇ࡟㣗࡭ࡿࡀࠊṧࡾࡢ 2 ๭ࢆఇᜥᮇ࡟

ࢢࣝࢥࢥࣝࢳࢥ࢖ࢻ࣍ࣝࣔࣥࡢࣜࢬ࣒ࡣ⤒ཱྀⓗ࡟ᢞ㣗࡭ࡿࠋࡇࢀࡣࡇࢀ࡛ᐇ㦂ᐊ࡛ࣞ࣋ࣝࡣࠊࡑࢀ࡞ࡾ࡟

୚ࡋࡓሙྜ࡟ྠㄪࡋ࡚ࣜࢬ࣒ࢆ้ࡴࡢ࡟ᑐࡋ࡚ࠊ㠀⤒つ๎ṇࡋ࠸㣗⏕ά࡜⪃࠼ࡽࢀࡿࡀࠊ᏶඲࡟つ๎ṇࡋ࠸ཱྀᢞ୚࡛ࡣࣜࢬ࣒ࡀᾘኻࡋ࡚ࡋࡲ࠺ࡇ࡜ࡀࢃ࠿ࡗࡓࠋ

ࢃࡅ࡛ࡣ࡞࠸ࠋࡑࡇ࡛ఇᜥᮇ࡟ࡣ඲ࡃ㣗࡭࡞࠸ࠕ㉸ࠖࡉࡽ࡟ࠊ✵⭠ࢆษ㝖ࡋ࡚ࡳࡿ࡜ࠊ⫢⮚᫬ィࡢࣜࢬ࣒ࡣ

つ๎ṇࡋ࠸㣗⏕άࢆࡉࡏࡿ࡜࡝࠺࡞ࡿࡢ࡛࠶ࢁ࠺࠿ࠋ

ኚࢃࡽ࡞࠿ࡗࡓࡀࠊࢢࣝࢥࢥࣝࢳࢥ࢖ࢻࡢࣜࢬ࣒ࡀᾘ

᭱㏆ࠊࠕ㉸ࠖつ๎ṇࡋ࠸㣗⏕άࢆࡍࡿ࡜ࠊࡑࢀࡔࡅ࡛

ኻࡋ࡚ࡋࡲࡗࡓ 5ࠋࡘࡲࡾࠊᑡ࡞ࡃ࡜ࡶࢢࣝࢥࢥࣝࢳ

㣗஦ㄏᑟᛶࡢ⫧‶ࢆᢚไࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀࡓ 43ࠋࡇࢥ࢖ࢻ࣍ࣝࣔࣥࡢࣜࢬ࣒ࡣࠊᰤ㣴⣲ࡀ྾཰ࡉࢀ࡚యෆ

ࢀࡣࣄࢺ࡛ࡶ㉳ࡇࡿࡇ࡜ࡀࠊ᭱㏆ሗ࿌ࡉࢀࡓ 44ࠋάື(⾑ᾮ)࡟ධࡿ࠿࡝࠺࠿࡛ࡣ࡞ࡃࠊ⭠⟶ࢆ௓ࡍࡿࡇ࡜ࡀ

ᮇࡔࡅ㣗࡭ࡿࠕ᫬㛫ไ㝈ᦤ㣗ࠖࡣࠊࢫࢡ࣮ࣟࢫࡢ㐣๫⚄⤒⣔ࡢ่⃭࡟࡞ࡗ࡚ྠㄪࡉࡏ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡿࠋ

ᦤྲྀ࡟ࡼࡿ⬡⫫⫢ࡸ㧗⬡⾑⑕ࡶᨵၿࡍࡿ 45ࠋࡇࢀࡽࡣࠊ୙つ๎࡞㣗⏕άࡀ೺ᗣ࡟Ⰻࡃ࡞࠸ࡔࡅ࡛࡞ࡃࠊつ๎ṇࡋ࠸㣗⏕άࡀࠊ✚ᴟⓗ࡟೺ᗣ࡟㈨ࡍࡿࡇ࡜ࢆᐇ㦂ⓗ࡟♧ࡋࡓࡶࡢ࡛࠶ࡿࠋ

(3) ࢢࣝࢥ࣮ࢫ
࢚ࢿࣝࢠ࣮※࡜ࡋ࡚᭱ࡶ㔜せ࡞ࢢࣝࢥ࣮ࢫࡀࣜࢬ
࣒ࢆྠㄪࡉࡏࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿ 48,49ࠋ⏕Ꮡ࡟㔜せ࡞࢚ࢿࣝࢠ࣮※࡟ࣜࢬ࣒ࡢྠㄪస⏝ࡀ࠶ࡿࡇ࡜ࡣྜ

6. 㣗஦ࢱ࢖࣑ࣥࢢࡀ⬡㉁௦ㅰࢆኚືࡉࡏࡿ࣓࢝ࢽࢬ

⌮ⓗ࡛࠶ࡿࠋࡇࢀࡣᇵ㣴⣽⬊࡛ࡶぢࡽࢀࡿ⌧㇟࡛࠶࣒ࡾࠊࢢࣝࢥ࣮ࢫࡣᇵ㣴⣽⬊ࡢࣜࢬ࣒ࡶྠㄪࡉࡏࡿࠋࡇ

(1) ࢖ࣥࢫࣜࣥ

ࢀࡣࠊᇵᆅ஺᥮࡟ࡼࡿ pH ࡞࡝ࡢኚ໬ࡀ኱ࡁ࠸ࡼ࠺࡛

㣗஦ࢱ࢖࣑ࣥࢢࡀయෆ᫬ィࢆྠㄪࡉࡏࡿᶵᵓ࡜ࡋ

࠶ࡿࠋᐇ㝿࡟ᇵᆅ஺᥮ࡔࡅ࡛᫬ィࡀࣜࢭࢵࢺࡉࢀࡿࠋ

࡚ࠊࡇࢀࡲ࡛࡟࣍ࣝࣔࣥ࡞࡝ࡢᾮᛶᅉᏊࠊ⚄⤒⣔ࠊయ

ᬑ㏻ᇵ㣴⣽⬊ࢆ౑࠺◊✲⪅ࡣᇵᆅ஺᥮ࡢ᫬㛫ࢆ࠶ࡲࠊᰤ㣴⣲ࠊάືࡀ௰௓ࡋ࡚࠸ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ

ࡾẼ࡟ࡋ࡚࠸࡞࠸ࠋ◊✲ᑐ㇟࡟ࣜࢬ࣒ࡀ࠶ࡿሙྜࠊ஦

46,47ࠋ㣗ᚋ࡟ୖ᪼ࡍࡿ⾑⢾್࡟పୗࡉࡏࡼ࠺࡜⮅⮚ࣛ๓ࡢᇵᆅ஺᥮ࡢ᫬㛫ࡀ⤖ᯝ࡟ᙳ㡪ࡋ࠿ࡡ࡞࠸ࡢ࡛࠶

ࣥࢤࣝࣁࣥࢫᓥ ǃ ⣽⬊࠿ࡽ㏿ࡸ࠿࡟࢖ࣥࢫࣜࣥࡀศ

ࡿࠋࡋ࠿ࡋࠊどⅬࢆ㏫࡟ࡋ࡚ࡳࡿ࡜ࠊ⣽⬊࡛࠶ࡗ࡚ࡶ

Ἢࡉࢀࡿࠋ㣗஦ࡢࢱ࢖࣑ࣥࢢࡣ࢖ࣥࢫࣜࣥࢆ௓ࡍࡿࡔ

ᶵ⬟ⓗศᴗࢆࡋ࡚௦ㅰⓗ▩┪ࡣ㠀ຠ⋡ⓗ࡛࠶ࡿࡓࡵࠊ

ࢁ࠺࡜࠸࠺௬ㄝࡣࠊ௨๓࠿ࡽ࠶ࡗࡓࡀࠊ༑ศ࡟ド᫂ࡉᇵ㣴⣽⬊ࢆ౑ࡗ࡚་⸆ရ࡞࡝ࡢ≀㉁⏕⏘ࢆࡍࡿሙྜࠊ

ࢀ࡚࠸࡞࠿ࡗࡓࠋࡑࡇ࡛⚾ࡓࡕࡣࠊ࢖ࣥࢫࣜࣥࡀ఩┦࠶࠼࡚ᇵᆅᡂศࡢࣜࢬ࣒ࢆຍ࠼ࡓᇵ㣴ἲࡀຠᯝⓗ࡛཯ᛂᴟᛶࢆᥥࡃ⫢⮚ࡢᙉ࠸ྠㄪᅉᏊ࡛࠶ࡿࡇ࡜ࢆ᫂

࠶ࡿ࠿ࡶࡋࢀ࡞࠸ࠋ

ࡽ࠿࡟ࡋࡓ 25ࠋ⫢⮚ࡔࡅ࡛ࡣ࡞ࡃࠊ࢖ࣥࢫࣜࣥࡢᶆⓗ⮚ჾ࡛࠶ࡿ⬡⫫⤌⧊ࡸ➽⫗ࡢྠㄪᅉᏊ࡛ࡶ࠶ࡿࠋࡲ

(4) ࣇࣝࢡࢺ࣮ࢫ

ࡓࠊᮅ㣗ᚋࡢ࢖ࣥࢫࣜࣥࡣ⫢⮚᫬ィࢆ๓㐍ࡉࡏࡿࡢ࡟

ࣇࣝࢡࢺ࣮ࢫࡣ཯ᛂᛶࡀ㧗ࡃẘᛶࡢ㧗࠸⢾㉁࡛࠶

ᑐࡋ࡚ࠊኪ㣗ᚋࡢ࢖ࣥࢫࣜࣥࡣ⫢⮚᫬ィࢆᚋ㏥ࡉࡏࡿ

ࡾࠊࢢࣝࢥ࣮ࢫ࡟ẚ࡭࢚ࢿࣝࢠ࣮※࡜ࡋ࡚ࡢព⩏ࡶప㸦఩┦཯ᛂ᭤⥺ࢆ♧ࡍࡓࡵ㸧ࠋࡘࡲࡾࠊኪ㣗ࡣࡑࢀࡔࡃࠊ⾑୰࡟࡯࡜ࢇ࡝᳨ฟࡉࢀ࡞࠸ࠋࣄࢺࡢṔྐࡢ୰࡛ࡅ࡛⬡㉁௦ㅰ␗ᖖࢆᘬࡁ㉳ࡇࡍྍ⬟ᛶࡀ࠶ࡿࠋྠࡌග

ࡣࣇࣝࢡࢺ࣮ࢫࢆᦤྲྀࡍࡿᶵ఍ࡣከࡃࡣ࡞࠿ࡗࡓࠋࡋ

่⃭࡛ࡶᮅࡢኴ㝧ගࡣ๓㐍ࡉࡏࡿࡀࠊኪࡢࢫ࣐࣍ࡢග

࠿ࡋࠊ㏆ᖺࠊࢫࢡ࣮ࣟࢫࠊ␗ᛶ໬⢾ࢆࡣࡌࡵ࡜ࡍࡿࣇ

ࡣᚋ㏥ࡉࡏ࡚ࡋࡲ࠺⌧㇟࡛࠶ࡿࠋ୍᪉ࠊࢢࣝ࢝ࢦࣥ㑇ࣝࢡࢺ࣮ࢫࡢᦤྲྀࡀ᱁ẁ࡟ቑ࠼ࡓࡓࡵࠊWHO ࡣ೺ᗣఏᏊࡢࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࢆ⏝࠸ࡓᐇ㦂࠿ࡽࠊ⤯㣗᫬࡬ࡢᝏᙳ㡪ࢆῶࡽࡍࡓࡵࡑࡢᦤྲྀࢆᢚ࠼ࡿࡼ࠺࡟່

࡟ศἪࡉࢀࡿࢢࣝ࢝ࢦࣥ࡟ࡣྠㄪຠᯝࡀ࡯࡜ࢇ࡝࡞

࿌ࡍࡿࡼ࠺࡟࡞ࡗࡓࠋ

࠸㸦ᮍⓎ⾲㸧ࠋࡇࢀࡲ࡛࢚ࢿࣝࢠ࣮ࡢ㐣๫ᦤྲྀࠊ≉࡟㣬࿴⬡⫫㓟ࡢྲྀࡾࡍࡂࡀࠊ⫧‶ࡸ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡢཎᅉ

᫬㛫⏕≀Ꮫ
26

Vol. 26, No. 1 (2020)࡜ࡉࢀ࡚ࡁࡓࠋ᭱㏆࡟࡞ࡾࢫࢡ࣮ࣟࢫࡸ␗ᛶ໬⢾࡞࡝࠶ࡿࡇ࡜ࡀࢃ࠿ࡗ࡚ࡁࡓࠋ࣐࢘ࢫ࡟ࢢࣝࢥ࣮ࢫ࡜࢔࣑

ࡢࣇࣝࢡࢺ࣮ࢫࡢྲྀࡾࡍࡂࡀࠊࡑࡢཎᅉ࡜ࡋ࡚ᨵࡵ࡚

ࣀ㓟ࢆ୚࠼ࡿ࡜ࠊ⫢⮚ࡔࡅ࡛࡞ࡃ SCN ࡢࣜࢬ࣒ࡶྠ

ࢡ࣮ࣟࢬ࢔ࢵࣉࡉࢀࡿࡼ࠺࡟࡞ࡗࡓࠋࣇࣝࢡࢺ࣮ࢫࡢ

ㄪࡉࢀࡿ࡜࠸࠺ሗ࿌ࡀ࠶ࡿ 48ࠋࣛࢵࢺึ௦ᇵ㣴⫢⣽⬊ྲྀࡾࡍࡂࡣࠊ⬡⫫⫢ࡸ࢖ࣥࢫࣜࣥ᢬ᢠᛶࠊ㧗⬡⾑⑕ࠊ࡟ࠊ༢୍࢔࣑ࣀ㓟ࢆ㧗⃰ᗘ࡟ฎ⌮ࡋࡓ࡜ࡇࢁࠊከࡃࡢ

㧗ᒀ㓟⾑⑕ࠊ⫧‶࡞࡝ࢆᘬࡁ㉳ࡇࡍࡇ࡜ࡀ▱ࡽࢀ࡚࠸࢔࣑ࣀ㓟࡟ࡑࢀࡒࢀ␗࡞ࡗࡓ᫬ィ㑇ఏᏊࢆື࠿ࡋࠊྠ

ࡿ 50ࠋࣄࢺࡢほᐹ◊✲࡛ࡣࠊࣇࣝࢡࢺ࣮ࢫࡢྲྀࡾࡍࡂ

ㄪᅉᏊ࡜ࡋ࡚ࡢྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿ㸦ᮍⓎ⾲㸧ࠋ⤯㣗ࡣ⫧‶࡜㛵㐃ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࡀ 51ࠊ㧗⬡⫫㣗᫬࡟ࡣ࢔࣑ࣀ㓟ࡣ⾑⢾್⥔ᣢࡢࡓࡵࡢ⢾᪂⏕ࡢཎᩱ࡟ẚ࡭⫧‶ࢆకࢃࡎ࡟⬡⫫⫢ࢆ㉳ࡇࡍࡇ࡜ࡀศ࠿ࡗ

࡜ࡋ࡚฼⏝ࡉࢀ࡚࠾ࡾࠊ㉳ᗋᚋࡢࢱࣥࣃࢡ㉁࣭࢔࣑ࣀ

࡚࠸ࡿࠋࡇࡢ⬡⫫⫢ࡣࠊ⫢⮚࡛ࡢ⬡⫫ྜᡂࡀஹ㐍ࡍࡿ㓟ࡢ⿵⤥ࡣ⫢⮚᫬ィࢆྠㄪࡉࡏࡿస⏝ࡀ࠶ࡿ࠿ࡶࡋ

ࡇ࡜࡟ࡼࡗ࡚㉳ࡇࡾࠊࡇࢀࡀ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮ࣟ

ࢀ࡞࠸ࠋ࣒࡟ࡘ࡞ࡀࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ⫢⮚ࡢ⬡㉁ྜᡂ⣔㓝⣲ࡣ㢧ⴭ࡞ᴫ᪥ࣜࢬ࣒ࢆ♧ࡍࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊࡇ

(6) ⬡㉁ࡢ᣺ᖜࡀࣇࣝࢡࢺ࣮ࢫ࡟ࡼࡗ࡚ቑ኱ࡍࡿࡇ࡜ࡀ⬡⫫୍᪉ࠊ⬡㉁ࡣྠㄪᅉᏊ࡜ࡋ࡚ࡢྍ⬟ᛶࡣྰᐃⓗ࡛࠶ྜᡂࡢஹ㐍࡟ࡘ࡞ࡀࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓ 52ࠋࡇࢀࡗࡓࡀࠊ㧗⬡⫫㣗ࡣ 1 ࿘ᮇ㸦1 ᪥㸧ࡢ㛗ࡉ㸦࿘Ἴᩘ㸧ࡀࠊάືᮇࡔࡅࢫࢡ࣮ࣟࢫࢆᦤྲྀࡉࡏࡿࠕ᫬㛫ไ㝈ᦤࢆኚ࠼࡚ࡋࡲ࠺ࡼ࠺࡛࠶ࡿ 55ࠋ࣐࢘ࢫࡢ 1 ࿘ᮇࡣࠊ⣙㣗ࠖࡀࠊ⬡⫫⫢ࡸ㧗⬡⾑⑕ࢆᢚ࠼ࡿཎᅉ࡛࡜⪃࠼ࡽࢀ

23.5 ᫬㛫࡛࠶ࡿࡀࠊ㧗⬡⫫㣗ࢆ୚࠼ࡿ࡜࡯ࡰ 24 ᫬㛫ࡿ 45ࠋ⏑࠸ࡶࡢࡢㄏᝨࡶࠊ㣗࡭ࡿࡢࢆ᫨ࡔࡅ࡟ࡍࢀࡤ

࡟࡞ࡗ࡚ࡋࡲ࠺ࠋ㏫࡟ࠊ⬡㉁ࡢ␗໬௦ㅰࢆಁ㐍ࡍࡿࢡࡑࡢᙳ㡪ࡣ㝈ᐃⓗ࡟࡞ࡿ࠿ࡶࡋࢀ࡞࠸ࠋࡸࡏᆺ࣓ࢱ࣎

ࣟࣇ࢕ࣈ࣮ࣞࢺ࡜࠸࠺⸆๣ࡣࠊ㧗⬡⫫㣗࡛㛗ࡃ࡞ࡗࡓࡢཎᅉࡀࡍ࡭࡚ࣇࣝࢡࢺ࣮ࢫࡢྲྀࡾ㐣ࡂ࡟ࡼࡿࡶࡢ

᫬ィࢆඖ࡟ᡠࡍస⏝ࢆ᭷ࡋ࡚࠸ࡿ 56ࠋPPARǂ ࢆ௓ࡍ࡛ࡣ࡞࠸ࡀࠊ⫢⮚⬡㉁௦ㅰࡢࣜࢬ࣒ࡢኚືࡀཎᅉ࡟࡞

ࡿ⤒㊰ࡀࣜࢬ࣒ࡢ࿘ᮇࡢ㛗ࡉࢆไᚚࡋ࡚࠸ࡿࡼ࠺࡛

ࡗ࡚࠸ࡿྍ⬟ᛶࡀ࠶ࡿࠋ

࠶ࡿࠋ᪥ᮏே࡛ࡣࠊࡑࢀ࡯࡝⫧‶࡛࡞࠸࡟ࡶ࠿࠿ࢃࡽࡎࠊ
࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡢᇶ┙࡛࠶ࡿ࢖ࣥࢫࣜࣥ

(7) ࡑࡢ௚ࡢ㣗ရᡂศ᢬ᢠᛶࡀᘬࡁ㉳ࡇࡉࢀࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋ⫧‶࡛௚ࡢᰤ㣴⣲࡛ࡶࠊ㣗ሷࡸࣅࢱ࣑ࣥ㸿ࡶ᫬ィࢆྠㄪࡉ࡞ࡃ࡚ࡶ␗ᡤᛶ⬡⫫⵳✚࡜ࡋ࡚⬡⫫⫢ࡀⰋࡃぢࡽࢀࡏࡿస⏝ࡀ▱ࡽࢀ࡚࠸ࡿࠋ㠀ᰤ㣴⣲࡛࠶ࡿࣞࢫ࣋ࣛࢺ

࡚࠸ࡿࠋ⬡⫫⫢࡜࠸࠺࡜࢔ࣝࢥ࣮ࣝᛶ⬡⫫⫢ࡀࡼࡃ▱࣮ࣟࣝࡶ᫬ィࢆື࠿ࡍస⏝ࡀ▱ࡽࢀࡿࡼ࠺࡟࡞ࡾ 57ࠊ

ࡽࢀ࡚࠸ࡿࡀࠊ㏆ᖺ࡯࡜ࢇ࡝㣧㓇Ṕࡀ࡞࠸࡟ࡶ࠿࠿ࢃ

㣗ရ୰࡟ࡣᴫ᪥᫬ィࢆไᚚࡍࡿᐇ࡟ከࡃࡢᡂศࡀ࠶

ࡽࡎࠊ⬡⫫⫢࡜デ᩿ࡉࢀࡿ౛ࡀከࡃ࡞ࡗࡓࠋࡇࢀࡀ⫢ࡿࡇ࡜ࡀࢃ࠿ࡿࠋẖ᪥ࡢ㣗஦ࡣࠊྠㄪᅉᏊ࡛┒ࡾࡔࡃ

⅖ࢆక࠺ሙྜࡀၥ㢟࡜࡞ࡗ࡚࠾ࡾࠊ࢔ࣝࢥ࣮ࣝ࡟ࡼࡽ

ࡉࢇ࡛࠶ࡾࠊྠㄪᅉᏊࢆ㣗࡭࡚࠸ࡿࡼ࠺࡞ࡶࡢ࡛࠶

࡞࠸⬡⫫ᛶࡢ⫢⑌ᝈ඲యࢆ NAFLD ࡜࿧ࡧࠊ᫂ࡽ࠿

ࡿࠋࡋࡓࡀࡗ࡚ࠊᬑ㏻ࡢ㣗஦ࢆࡋ࡚࠸ࢀࡤࠊࡔ࠸ࡓ࠸

࡞⫢㞀ᐖࡀ㉳ࡁࡓሙྜࡣ NASH ࡜デ᩿ࡉࢀࡿ 50ࠋࡸྠㄪ่⃭࡟࡞ࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋ

ࡏᆺ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒࡛ࣟ㉳ࡁࡿ⬡⫫⫢ࡢⓎ⑕࣓࢝ࢽࢬ࣒ࡣ࡯࡜ࢇ࡝ࢃ࠿ࡗ࡚࠸࡞࠸ࠋ⬡⫫⫢ࡀᙧ

7. ࢫ࣐࣮ࢺ࡞㣗⏕ά㸦SNS㸧࡜యෆ᫬ィࡢྍど໬ᡂࡉࢀࡿ࡜ࠊ⫢⮚࠿ࡽ୰ᛶ⬡⫫ࡢᨺฟࡀቑ኱ࡋ࡚㧗୰ࡇࢀࡲ࡛ࡢ▱ぢ࠿ࡽࠊయ࡟ࡼ࠸ࢫ࣐࣮ࢺ࡞㣗⏕άᛶ⬡⫫⾑⑕ࢆᘬࡁ㉳ࡇࡍࠋࡇࢀࡀ⮅⮚ࡢ⬡⫫⵳✚ࢆಁ㸦SNS: Smart Nutr Style㸧࡜ࡣ࡝࠺࠸ࡗࡓࡶࡢ࡞ࡢ

ࡋࣛࣥࢤࣝࣁࣥࢫᓥ ǃ ⣽⬊ࡢᶵ⬟ࢆపୗࡉࡏ࡚ࠊ2 ᆺ࠿ࠋ⡆༢࡟࠸࠼ࡤࠊάືᮇ࡟㣗࡭࡚ఇᜥᮇ࡟㣗࡭࡞࠸ࠊ⢾ᒀ⑓ࢆⓎ⑕ࡍࡿྍ⬟ᛶࡀ࠶ࡿ 53ࠋࡘࡲࡾࠊ⬡⫫⫢⮬᫨ኪࡢ࣓ࣜࣁࣜࡢつ๎ṇࡋ࠸㣗⏕ά࡛࠶ࡿࠋάືᮇࡢ

㌟ࡀࡸࡏ࡚࠸ࡿேࡢ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟࡢཎ

᭱ึࡢ㣗஦࡛࠶ࡿᮅ㣗ࡀྠㄪ࡟㔜せ࡛࠶ࡿࠋ༑ศ࡞⤯ᅉ࡟࡞ࡗ࡚࠸ࡿሙྜࡶ࠶ࡿࠋࣇࣝࢡࢺ࣮ࢫ࡟ࡼࡿ⬡⫫㣗ࢆࡋ࡚࠸࡞࠸࡜ࡁࡢᮅ㣗ࡣࠊྠㄪຠᯝࡣᑡ࡞࠸ࡔࢁ

⫢ࡢ࣓࢝ࢽࢬ࣒ࡣࠊࡸࡏᆺ࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟ

࠺ࠋࡲࡓࠊኪ㣗ࡣ⫢⮚ࡢ᫬ィࢆ࠿࠼ࡗ࡚ᝏ໬ࡉࡏࡿ᪉

ࡢࣔࢹࣝ࡜౑⏝࡛ࡁࡿ࡜⪃࠼ࡽࢀࠊࡇࡢ⬡⫫⫢ࡢᑐ⟇ྥ࡟ㄪᩚࡉࡏ࡚ࡋࡲ࠺ࠋୖ࡛㏙࡭ࡓࡼ࠺࡟ࠊ㣗஦ࡣྠ࡜ࡋ࡚ࠊ᫬㛫ᰤ㣴Ꮫⓗ௓ධࡢྍ⬟ᛶࡀᮇᚅࡉࢀࡿࠋ

ㄪᅉᏊࡢ᮰࡞ࡢ࡛ࠊ⢾㉁࡜ࢱࣥࣃࢡ㉁ࡀධࡗ࡚࠸ࡿᬑ
㏻ࡢ㣗஦࡛࠶ࢀࡤࠊ༑ศຠᯝࡣᚓࡽࢀࡿ࡛࠶ࢁ࠺࡜ᛮ

(5) ࢔࣑ࣀ㓟ࢃࢀࡿࠋࡑࢀ࡛ࡣࠊ㣗஦ࡣ 3 ᅇࡕࡷࢇ࡜㣗࡭࡞࠸࡜࠸

㣗஦ᅉᏊ࡜ࡋ࡚ࠊ⢾㉁࡜ࢱࣥࣃࢡ㉁ࡀ⫢⮚ࡢᙉ࠸ྠࡅ࡞࠸ࡢ࠿ࠋṔྐⓗ࡟㣗஦ࡢᅇᩘࡣࠊ㏆௦࡟࡞ࡗ࡚ 2ㄪᅉᏊ࡜ࡋ࡚ാࡃ 54ࠋ࢔࣑ࣀ㓟࡟ࡶ༢⊂࡛ྠㄪస⏝ࡀ

ᅇ࠿ࡽ 3 ᅇ࡟࡞ࡗࡓ࡜࠸ࢃࢀ࡚࠸ࡿࠋ㣗࡭㐣ࡂ࡟࡞ࡗ᫬㛫⏕≀Ꮫ

Vol. 26, No. 1 (2020)27

ᅗ 3 యෆ᫬ィࢆྍど໬ࡍࡿࢫ࣐࣮ࢺࣇ࢛ࣥ࢔ࣉࣜࠕ᫬㛫ᰤ㣴Ꮫ᫬ィࠖ㣗஦ࢆࡋࡓ࡜ࡁࡸࢺ࢖ࣞ࡟⾜ࡗࡓ࡜ࡁ࡟ࢱࢵࣉࡋࠊẖ᪥ࡢయ㔜ࢆධຊࡍࡿࠋ╧╀᫬ィࡸάື᫬ィࠊ௦ㅰ᫬ィࠊ⭠ά᫬ィࠊBMI ࡜యෆ᫬ィࡢࡎࢀࡢ㛵ಀ࡞࡝ࡀィ⟬ࡉࢀࡿࡼ࠺࡟࡞ࡗ࡚࠸ࡿࠋᐇドᐇ㦂ᚋࠊ௒ᖺ୰࡟බ㛤ணᐃ࡛࠶ࡿࠋ

࡚ࡣ࠸ࡅ࡞࠸ࡀࠊ1 ᪥ 3 ᅇ௨ୗࡢሙྜࡼࡾࠊ4 ᅇࠊ5࢖࣑ࣥࢢ㸪≉࡟ᮅ㣗㸦ࡑࡋ࡚㸪ࡑࢀࢆྎ↓ࡋ࡟ࡍࡿኪ

ᅇ࡜ᅇᩘࡀከ࠸᪉ࡀࠊ⫧‶ࠊ⾑୰⬡㉁࡞࡝ࡢᣦᶆࡀṇ㣗㸧ࡢࢱ࢖࣑ࣥࢢࢆグ㘓ࡍࡿࡇ࡜࡟ࡼࡗ࡚యෆࡢ௦ㅰ

ᖖ⠊ᅖ࡟ධࡿ๭ྜࡀከࡃ࡞ࡗ࡚࠸ࡿࠋࡓࡔࠊᅇᩘࡣቑ

ࡢࣜࢬ࣒ࢆ᥎

ࡸࡋ࡚ࡶኪ㣗ࢆྲྀࡗ࡚ࡋࡲ࠺࡜ព࿡ࡀ࡞࠸ࡇ࡜ࡶ♧ࡋ࡚࠸ࡿ㸦ࠕ᫬㛫ᰤ㣴Ꮫ᫬ィࠖ௒ᖺ୰࡟බ㛤ணᐃ㸹ᅗࡉࢀ࡚࠸ࡿࠋࡇࡢࡼ࠺࡟άືᮇࡢ᭱ึ࡜᭱ᚋࡢ㣗஦ࡢ

3㸧59ࠋ㣗஦ࡢࢱ࢖࣑ࣥࢢࡸ᤼౽㸪᤼ᒀࢆࢱࢵࣉࡋ㸪యࢱ࢖࣑ࣥࢢࡀ೺ᗣ࡟㔜せ࡞ᙳ㡪ࢆཬࡰࡋ࡚࠸ࡿࡇ࡜

㔜ࢆධຊࡍࡿ࡜㸪╧╀㸪άືࡢࣜࢬ࣒ࡢ௚㸪యෆ᫬ィࡀ࠾࠾ࡼࡑ⌮ゎࡉࢀࡿࠋ㸦௦ㅰࣜࢬ࣒㸧ࢆィ⟬ࡍࡿ࡜࠸࠺ࡶࡢ࡛࠶ࡿࠋࡇࢀࢆ

ࡍࡿࢫ࣐࣮ࢺࣇ࢛ࣥࡢ࢔ࣉࣜࢆసᡂ

࡜ࡇࢁࡀ᫬㛫ᰤ㣴Ꮫࡣࠊࡲࡔ⮫ᗋࡢሙ㠃࡛༑ศ࡟ά

౑࠼ࡤ࠾࠾ࡼࡑࡢయෆ᫬ィࢆྍど໬࡛ࡁࠊ஘ࢀ࡚࠸ࢀ

⏝ࡉࢀࡿࡼ࠺࡞≧ἣ࡟࡞ࡗ࡚࠸࡞࠸ࠋࡑࡢཎᅉࡣࣄࢺ

ࡤ┤ࡍࡇ࡜ࡀ࡛ࡁࡿ࠿ࡶࡋࢀ࡞࠸ࠋయෆ᫬ィࢆྍど໬ࡢయෆ᫬ィࢆ▱ࡿࡇ࡜ࡀ㞴ࡋ࠸࠿ࡽ࡛࠶ࡿࠋࣄࢺ࡛య

ࡋ࡚ࠊ᫬㛫ᰤ㣴Ꮫⓗᰤ㣴௓ධࢆᐇ⌧ࡍࡿࡇ࡜ࡀᮇᚅࡉ

ෆ᫬ィࢆ

ࢀࡿࠋ

ࢁ࠺࡜ࡍࡿ࡜㸪ᩘ᫬㛫࠾ࡁ࡟᥇⾑ࡋ࡚ⓑ⾑⌫ࡢ᫬ィ㑇ఏᏊࡢⓎ⌧ࣜࢬ࣒ࢆㄪ࡭ࡿࡇ࡜࡟࡞ࡿࠋࡲ
ࡓ㸪ࢥࣝࢳࢰ࣮ࣝ࡞࡝ࡢ᪥࿘ࣜࢬ࣒ࢆ♧ࡍ࣍ࣝࣔࣥࢆ
ࡿࡇ࡜ࡶ࡛ࡁࡿ㸦๪⭈᫬ィ㸧ࠋᑡࡋ౵くᛶࡢప࠸᪉
ἲ࡜ࡋ࡚㸪ᩘ᫬㛫࠾ࡁ࡟㧥ࡢẟࢆᩘᮏᢤ࠸࡚ࡑࡢẟ᰿⣽⬊ࡢ᫬ィ㑇ఏᏊࢆᐃࡍࡿ᪉ἲࡀሗ࿌ࡉࢀ࡚࠸ࡿ

58ࠋࡋ࠿ࡋ㸪࠸ࡎࢀࡶ⌧ᐇⓗ࡛࡞࠸ࠋࡑࡇ࡛⚾ࡓࡕࡣ㸪ୖ࡛ࡢ㏙࡭࡚ࡁࡓࡼ࠺࡟㣗஦ࡢࢱ

᫬㛫⏕≀Ꮫ
28

Vol. 26, No. 1 (2020)

8. ⏕≀᫬ィࡢ೺ᗣ⛉Ꮫ࣭೺ᗣᰤ㣴Ꮫ࡬ࡢᑗ᮶ᒎᮃ
(1) ࣉࣞࢩࢪࣙࣥᰤ㣴Ꮫ
ୖ࡛㏙࡭࡚ࡁࡓࡼ࠺࡟ࠊಶே࡟᭱㐺໬ࡉࢀࡓᰤ㣴Ꮫࠊࠕࣉࣞࢩࢪࣙࣥᰤ㣴Ꮫࠖࠊࡶࡋࡃࡣಶே࡟᭱㐺໬ࡉࢀࡓ་Ꮫࠊࠕࣉࣞࢩࢪࣙࣥ་Ꮫࠖࢆࡍࡿ࡟࠶ࡓࡾࠊಶ
ேࡢ≉ᛶࢆ᭱᪂ࡢ⏕࿨⛉Ꮫࡸ᝟ሗ㏻ಙᢏ⾡ࢆ౑ࡗ࡚᫂ࡽ࠿࡟ࡍࡿᚲせࡀ࠶ࡿࠋࡑࡢಶே࡟᭱㐺࡞ᰤ㣴ࢆᥦ⏕άࡀ㏦ࡽࢀࡿ࡜ᛮࢃࢀࡿࠋ㏆࠸ᑗ᮶ࠊព㆑ࡋ࡞ࡃ࡚

౪ࡋ࡚ࠊࡑࡢࣇ࢕࣮ࢻࣂࢵࢡࢆᅇࡍࡇ࡜࡟ࡼࡾࠊព㆑

ࡶ೺ᗣⓗ࡛࠾࠸ࡋ࠸㣗஦ࡀ࡛ࡁࠊᑡࡋ࡛ࡶ㌟య࡟␗ᖖࡋ࡞ࡃ࡚ࡶᖖ࡟೺ᗣⓗ࡞㣗⏕άࢆ┠ᣦࡑ࠺࡜ࡍࡿࡶ

ࡀ࠶ࢀࡤࡑࢀࢆண▱ࡋ࡚ࠊᮍ↛࡟㣗஦ࡸ㐠ືࡼࡗ࡚೺

ࡢ࡛࠶ࡿࠋࢤࣀ࣒᝟ሗࡸ೺ᗣデ᩿ࡢ್ࢆࣅࢵࢢࢹ࣮ࢱ

ᗣࢆ⥔ᣢࡋࠊ೺ࡸ࠿࡞ຍ㱋࡜㧗࠸ QOL ࡢ࠶ࡿᖾ⚟ᗘ࡜ࡋ࡚౑⏝ࡋ࡚ࠊேᕤ▱⬟㸦AI㸧ࡢຓࡅࢆ೉ࡾ࡚⾜࠾ࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ

࠺࡜ࡍࡿࡶࡢ࡛࠶ࡿ 2ࠋᴫ᪥᫬ィࡣࠊྠㄪࢆཷࡅᅇࡾጞࡵࡿ࡜ࠊࡑࡢᚋྠㄪ

(2) ࣜࢬ࣮࣒ࣔ㸦Rhythmome㸧ᅉᏊࡀ᮶࡞ࡃ࡚ࡶࡑࡢࣜࢬ࣒ࢆ้ࡳ⥆ࡅࡿࠋࡘࡲࡾࠊ

ᴫ᪥᫬ィࡀಶேࢆ≉ᐃࡍࡿࠕయ㉁ࠖࡢ୍ࡘ࡛࠶ࡿࡇ

᫬ᕪࡰࡅࡢࡼ࠺࡟ࠊᆅ⌫ࡢ⿬ഃ࡟⛣ືࡋ࡚ࡶࡋࡤࡽࡃ

࡜ࢆ㏙࡭࡚ࡁࡓࡀࠊ⏕≀ࡀᣢࡘከᵝ࡞ࣜࢬ࣒ࡶಶேࡢ

ࡣ᪥ᮏ᫬㛫࡛యෆ᫬ィࡣືࡁࠊ1 㐌㛫ࡄࡽ࠸࡛⌧ᆅ᫬೺ᗣ≧ែࡸࠕయ㉁ࠖࢆ≉ᚩ࡙ࡅࡿࣃ࣓࣮ࣛࢱ࣮࡜ࡋ࡚

㛫࡟័ࢀࡿࠋື≀࡛ࡣ㣗஦࡟ࡼࡿయෆ᫬ィࡢ᫬ᕪㄪ⠇฼⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡿ࡜⪃࠼ࡽࢀࡿࠋ་Ꮫࡸ೺ᗣ⛉Ꮫࡶᾘ໬ჾ⣔࡛ࡣ 1 㐌㛫࡯࡝ࠊ㐜࠸⮚ჾ࡛ࡣᩘ㐌㛫࠿࠿ࡢศ㔝࡛ࡣྂࡃ࠿ࡽ⏕≀ࡢࣜࢬ࣒ࢆᗈࡃ฼⏝ࡋ࡚ࡁࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ 60ࠋࡘࡲࡾࠊ᪥ᖖ⏕ά࡛ࡣࠊయ

ࡓࠋ⮫ᗋ࡛౑⏝ࡉࢀࡿᚰᢿᩘࠊᚰ㟁ᅗࠊ⬻Ἴࠊ࿧྾ࠊ

ෆ᫬ィࡣ㣗஦࡟ࡼࡗ࡚ไᚚࡉࢀࡿ▷୰ᮇⓗ࡞ࠕయ㉁ࠖ

య࡛࠶ࡾࠊ㣗஦ࢱ࢖࣑ࣥࢢࡢ௓ධ࡟ࡼࡗ࡚ᨵၿྍ⬟࡞ࡢᴫᖺ࿘ᮇ࡞࡝㠀ᖖ࡟ከࡃࡢࣜࢬ࣒ࡀ⚾ࡓࡕࡢ㌟యࡢ

࡛࠶ࡿࠋయෆ᫬ィ࡜࠸࠺▷୰ᮇⓗ࡞య㉁ࡢ஘ࢀࡀࠊ㛗୰࡟ࡣᏑᅾࡋ࡚࠸ࡿࠋࡓ࡜࠼ࡤᚰ㟁ᅗ࡞࡝ࡑࢀ༢⊂࡛࠸ᮇ㛫⥆ࡃ࡜⑌ᝈ࡟ࡘ࡞ࡀࡿྍ⬟ᛶࡀ࠶ࡿࠋࡇࡢࡼ࠺

ࡢデ᩿ᢏ⾡ࠊゎᯒ᪉ἲࡶ☜❧ࡋ࡚࠸ࡿࡀࠊࡑࡇ࡟ࡣࡲ

࡟㣗஦ࡢࢱ࢖࣑ࣥࢢࡣࠊ೺ᗣయ㉁ࡸయ㉁ᨵၿࡢ࢝ࢠ࡛

ࡔ㞃ࢀࡓ᝟ሗ㸦ࣅࢵࢢࢹ࣮ࢱ㸧ࡀከࡃ₯ࢇ࡛࠸ࡿ࡜ᛮ

࠶ࡿࠋྠᵝ࡟ගࡢไᚚࡶ╧╀࡜ࡢ㛵ಀ࡛యෆ᫬ィࢆไࢃࢀࡿࠋࡇࢀࡽከࡃࡢࣜࢬ࣒ࢆ⥲య࡜ࡋ࡚⪃࠼࡚ࠊ⛊ᚚࡋ࡚ࠊయ㉁ᨵၿࢆᑟࡃࡶࡢ࡜ࡋ࡚◊✲ࡀࡉࢀ࡚࠸

࠿ࡽᖺ࡟࠸ࡓࡿ᫬㛫㍈ࡢࣜࢬ࣒ࡢ⥲య࡜ࡋ࡚ࡢࣜࢬ

ࡿࠋ࣮࣒ࣔ㸦rhythmome㸧࡜ࡋ࡚࡜ࡽ࠼ࡿࡇ࡜࡛ࠊࡇࢀࢆ

ࠊ⾑ᅽࠊ⏕⌮࡞࡝ࡢ௚࡟ࡶࠊయ⠇࿘ᮇࠊᴫ᭶࿘ᮇࠊ

ࣉࣞࢩࢪࣙࣥ་Ꮫࡸࣉࣞࢩࢪࣙࣥᰤ㣴Ꮫ࡛ࡣࠊ࣑࢜

೺ᗣ⛉Ꮫ࡟࠾ࡅࡿಶேࡢ≉ᛶࢆỴࡵࡿࡇ࡜ࡀ࡛ࡁࡿ

ࢵࢡࢫࣂ࢖࢜ࣟࢪ࣮࡜࠸ࢃࢀࡿࡼ࠺࡞⥙⨶ⓗゎᯒ㸦ࢤ㸦ᅗ 4㸧ࠋࡍ࡛࡟☜❧ࡋࡓデ᩿ἲࡣ㠀ᖖ࡟ࡼ࠸⮫ᗋ᳨ࣀ࣒ࠊࢺࣛࣥࢫࢡࣜࣉࢺ࣮࣒ࠊࣉࣟࢸ࣮࣒࢜ࠊ࣓ࢱ࣎

ᰝἲ࡛࠶ࡿࡀࠊࡇࡢࢹ࣮ࢱࡢࡶࡘࠊẼ࡙࠸࡚࠸࡞࠸ல

࣮࣒ࣟࠊ࣐࢖ࢡࣟࣂ࢖࣮࣒࢜࡞࡝㸧࡛ᚓࡽࢀࡓ⤖ᯝࢆ⣽࡞ࣅࢵࢢࢹ࣮ࢱ࡜ࡋ࡚ࡢ࢔࢘ࢺ࣒࢝ࢆ᥎

᝟ሗ㏻ಙᢏ⾡ࠊAI ࢆ౑ࡗ࡚ಶேࡢ≉ᛶࢆࡲࡎ᫂ࡽ࠿

ᅾⓗྍ⬟ᛶࢆఙࡤࡍࡶࡢ࡜⪃࠼ࡽࢀࡿࠋࡇࢀࡣᚑ᮶ࡢ

࡟ࡍࡿࠋࡑࡋ࡚ಶேᑐᛂࡍࡿ೺ᗣⓗ࡞㣗஦ࢆࡑࢀࡒࢀ

☜❧ࡋࡓゎᯒἲ࡟ຍ࠼ࠊࣜࢬ࣒ࢆ୕ゅ㛵ᩘࠊࣇ࣮࢚ࣜ

ࡢࣛ࢖ࣇࢫࢱ࢖ࣝ࡟ྜࢃࡏ࡚ᥦ౪ࡍࡿࡶࡢ࡛࠶ࡿࠋᚑ

ኚ᥮࡞࡝࡛⣽ศ໬ࡉࢀࡓᐃ㔞ⓗ࡞ᩘ್࡟⨨ࡁ᥮࠼ࠊ௚

᮶ࡢᰤ㣴Ꮫࡣࠊࡇࢀࡲ࡛ࡢ▱ぢࢆ࠶࡚ࡣࡵࡼ࠺࡜ࡍࡿ

ࡢࢹ࣮ࢱ࡜㛵㐃௜ࡅࡿࡇ࡜࡛ࠊࣉࣞࢩࢪࣙࣥ་Ꮫࡸࣉ

ࠕ࣮ࣝࣝᣦྥᆺ࡛ࠖ࠶ࡗࡓࡀࠊࣉࣞࢩࢪࣙࣥᰤ㣴Ꮫࡣࣞࢩࢪࣙࣥᰤ㣴Ꮫ࡞࡝ࢹ࣮ࢱ㥑ືᆺࡢ೺ᗣ⛉Ꮫ࡬ᛂࣅࢵࢢࢹ࣮ࢱ࠿ࡽᡂᯝ㸦࢔࢘ࢺ࣒࢝㸧ࢆ┠ᣦࡍࠕ࢔࢘

⏝ྍ⬟࡛࠶ࡿࠋ

ࡍࡿ₯ࢺ࣒࢝ᣦྥᆺࠖ࡬ࡢኚ᥮࡛࠶ࡿࠋಶேࡢ≉ᛶ࡜࠸࠺ࡢ
ࡣࠊࡇࢀࡲ࡛ࠕ୍⯡࡟೺ᗣⓗࠖ࡜࠸ࢃࢀࡓࠕ࣮ࣝࣝᣦ

9. ࠾ࢃࡾ࡟

ྥࠖࡢࡶࡢ࡛ࡣ࡞ࡃࠊࡓ࡜࠼ࡤ࢔࢘ࢺ࣒࢝࡜ࡋ࡚㣗ᚋ

ࡇࡇࡲ࡛㏙࡭࡚ࡁࡓ᫬㛫ᰤ㣴Ꮫ࡟ࡣࠊ2 ࡘࡢഃ㠃ࡀ⾑⢾್ࢆ౛࡟࡜ࡿ࡜ࠊࡇࡢே࡛ࡣᑑྖࡣ㣗ᚋ⾑⢾್ࢆ࠶ࡿࠋ୍ࡘࡣࠊࡇࡢࢱ࢖࣑ࣥࢢ࡛㣗࡭ࡿ࡜Ⰻ࠸ࠊ࡞࡝

ୖࡆࡿࡀࣆࢨࡣୖࡆ࡞࠸࡞࡝ࡢࡼ࠺࡞ࢹ࣮ࢱࡢ㞟✚࡜࠸ࢃࢀࡿࡼ࠺࡞ࠕⰋ࠸ࢱ࢖࣑ࣥࢢࠖࡢࡇ࡜࡛࠶ࡿࠋ

࡜ࡋ࡚ AI ࡢຓࡅࢆ೉ࡾ࡚ฟࡉࢀࡓಶேࡢ≉ᛶ࡛࠶ࡿࠋ

ࡶ࠺୍ࡘࡣࠊ㣗஦ࡢࢱ࢖࣑ࣥࢢࡀయෆ᫬ィࢆྠㄪࡉࡏ

᪂ࡋ࠸ศ㔝࡜࠸࠺ࡼࡾࠊᰤ㣴Ꮫࡢࣃࣛࢲ࢖࣒ࢩࣇࢺࡢ

ࡿ࡞࡝ࡢࠊࠕయෆ᫬ィࡢṇᖖ໬స⏝ࡢࢱ࢖࣑ࣥࢢ࡛ࠖ

ࡼ࠺࡞ࡶࡢ࡛࠶ࡿࠋಶேࡢ≉ᛶࢆ≉ᐃࡋࡓᚋࡣࠊ᭱㐺࠶ࡿࠋ๓⪅࡛ࡣࠊኪ㣗ࢆ㣗࡭ࡿ࡜ࡑࡢ࢚ࢿࣝࢠ࣮ࡣ౑

࡞㣗஦ࢆᥦ᱌ࡍࡿࡇ࡜࡟࡞ࡿࠋ⌧ᅾࠊಶே࡟᭱㐺໬ࡉ⏝ࡉࢀ࡞࠸ࡓࡵࠊྠࡌ࢚ࢿࣝࢠ࣮࡛ࡶᮅ᫨࡟ẚ࡭࡚ኴࢀࡓᰤ㣴⣲ࢆィ⟬࡛ࡁࡿࡼ࠺࡟ࡍࡿ N ᘧࣃ࣮ࢯࢼࣝ

ࡾࡸࡍ࠸ࡇ࡜࡟࡞ࡿࠋᚋ⪅࠿ࡽࡣయෆ᫬ィࢆ஘ࡍస⏝㣗஦ᦤྲྀᇶ‽࡜࠸࠺ Web ࢶ࣮ࣝࢆබ㛤ࡋ࡚࠸ࡿ 61ࠋࡀ࠶ࡿ࡜࠸࠺ࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋࡋࡓࡀࡗ࡚ࠊኪ㣗ࡣࡑࡋ࡚ࡑࡢே࡟ᚲせ࡞ᰤ㣴⣲ࢆࡍ࡭࡚‶ࡓࡍ೺ᗣⓗ஧㔜࡟࣓ࢱ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟ࡬㐍ࡵࡿస⏝ࡀ࠶࡞ࣞࢩࣆࡢᥦ᱌ࡸࠊ㡢ኌධຊ࡛㣗࡭ࡓࡶࡢࡢࣇ࢕࣮ࢻ

ࡿࡇ࡜࡟࡞ࡿࠋ୍᪉ᮅ㣗ࡣࠊ๓⪅࠿ࡽࡣ⤯㣗ࡢࡓࡵୗࣂࢵࢡࡍࡿࢩࢫࢸ࣒ࡶࡘࡃࡿணᐃ࠶ࡿࠋࡇࡇ࡟ࠊయෆ

ࡀࡗࡓ⾑⢾್ࢆ࠶ࡆࡿࡓࡵ⢾ࡢ⿵⤥ࡸ⢾᪂⏕ࡢཎᩱࣜࢬ࣒࡜࠸࠺ࠕయ㉁ࠖࢆຍ࠼ࡿࡇ࡜࡛ࠊࡼࡾ೺ᗣ࡞㣗࡛࠶ࡿ࢔࣑ࣀ㓟⿵⤥࡟ຠᯝⓗ࡞Ⰻ࠸ࢱ࢖࣑ࣥࢢ࡛࠶

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ᅗ 4 ࣜࢬ࣮࣒ࣔࡢᴫᛕᅗ࡜ࡑࡢά⏝⏕యࣜࢬ࣒ࡢ⥲య࡜ࡋ࡚ࡢࣜࢬ࣮࣒ࣔ㸦rhythmome㸧ࢆ೺ᗣ⛉Ꮫࡢࣅࢵࢢࢹ࣮ࢱ࡟฼⏝ࡍࡿᴫᛕᅗ

ࡾࠊᚋ⪅࠿ࡽࡣయෆ᫬ィࢆṇᖖ໬ࡉࡏ࡚೺ᗣ࡟࡞ࡿࢱ

ࡣࠊఱ࠿⏕⏘ࡍࡿࡓࡵࡔࡅ࡟ാࡃࡢ࡛ࡣ࡞ࡃࠊࠕ᫬ࠖ

࢖࣑ࣥࢢࡢ㣗஦࡛ࡶ࠶ࡿࠋ≉࡟ᚋ⪅ࡢయෆ᫬ィྠㄪస࡟౯್ࢆ୚࠼ࡿࡓࡵ࡟ാࡃࡢࡔࠖ࡜࠸ࡗࡓ࡜࠸ࢃࢀ࡚

⏝ࡣࠊ㣗஦ࡢࢱ࢖࣑ࣥࢢ࡟ࡼࡗ࡚య㉁ᨵၿࢆࡍࡿࡇ࡜

࠸ࡿࠋࠕ᫬ࠖ࡟౯್ࢆ୚࠼ࡿ࡜ࡣࠊே⏕࡟ព࿡ࢆ୚࠼

ࢆព࿡ࡍࡿࠋ᫬㛫ᰤ㣴Ꮫ௨እ࡟ࡶࠊ᫬㛫⸆⌮Ꮫ࡛ࡣࠊ㇏࠿࡟ࡍࡿࡇ࡜࡛࠶ࡿࠋࡑࡇ࡛⚾ࡣࠊࠕ㣗࡭ࡿࡇ࡜ࡣࠊ

ຠᯝࢆ᭱኱㝈࡟Ⓨ᥹ࡍࡿᢞ୚᫬㛫ࡸࠊ๪స⏝ࢆ᭱ᑠ㝈యࢆసࡿࡓࡵࡔࡅ࡟ാࡃࡢ࡛ࡣ࡞ࡃࠊᴫ᪥᫬ィࢆ㏻ࡋ࡟ࡍࡿᢞ୚᫬㛫࡞࡝ࡀ◊✲ࡉࢀ࡚࠸ࡿࠋ⸆ࡢᢞ୚ࡔࡅ

࡚ࡑࡢࠕ᫬ࠖ࡟೺ᗣ࡜࠸࠺౯್ࢆ୚࠼ࡿࡓࡵാࡃࡢࡔࠖ

࡛࡞ࡃ἞⒪ࡸࣜࣁࣅࣜ㸪㐠ື࡞࡝ࡶຠᯝⓗ࡞᫬㛫ࡀ▱࡜ゝ࠸᥮࠼ࡽࢀࡿ࡜ᛮࡗ࡚࠸ࡿࠋ㣗ࡣࠊࡑࡢࢱ࢖࣑ࣥ

ࡽࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁ࡚࠸ࡿࠋࡇࢀࡽࡢᇶ┙ࡣṇᖖ࡞

ࢢࢆ㏻ࡋ࡚ࠊ⚾ࡓࡕࡢ೺ᗣࢆ㣴࠸ࠊ⏕࿨ࢆࡼࡾ㇏࠿࡞

యෆ᫬ィ࡛࠶ࡿࠋࡇࡢṇᖖ࡞యෆ᫬ィࢆసࡿࡢࡀ᫬㛫ࡶࡢ࡟ࡍࡿࠋศᏊ⏕≀Ꮫⓗศᯒⓗゎᯒࢆ」ྜⓗᗙᶆ㍈ᰤ㣴Ꮫࡢᙺ๭࡛࠶ࡿࠋ᫬㛫ᰤ㣴Ꮫࡣ㸪ࡍ࡭࡚ࡢࠕ᫬㛫࡟࠾࠸࡚⥲ྜⓗ࡟ᤊ࠼ࠊ⤫ྜࢩࢫࢸ࣒࡜ࡋ࡚ࡢ⏕࿨యʊʊᏛࠖࡢᇶ┙ࢆᨭ࠼ࡿศ㔝࡛࠶ࡿࠋ㣗஦ࡔࡅ࡛࡞ࡃᢞ

ࡢ⌮ゎࢆ㏻ࡋࡓᰤ㣴Ꮫ◊✲࡜ᐇ㊶ࢆࡋ࡚࠸ࡁࡓ࠸ࠋ

⸆ࠊࣜࣁࣅࣜ࡞࡝ࡢຠᯝࢆ┦஌ⓗ࡟ୖࡆࠊ⥲ྜⓗ࡞ண㜵་⒪ࡢ᪂࢔ࣉ࣮ࣟࢳ࡟࡞ࡿࡇ࡜ࡶᮇᚅࡉࢀࡿࠋ

ㅰ㎡

ᰤ㣴Ꮫࡣࡇࢀࡲ࡛୺࡟ఱࢆ㣗࡭ࡿ࠿࡟ὀ┠ࡋ࡚ࡁᮏ⥲ㄝࢆ᭩ࡃ࡟࠶ࡓࡾ㈗㔜࡞᝟ሗࢆ࠸ࡓࡔ࠸ࡓᮾி

ࡓࡀࠊ㣗࡭᪉㸦㣗ࡢ 5W1H㸧ࢆ⪃࠼࡚ࠊつ๎ṇࡋࡃ㈼኱Ꮫࡢ῝⏣ྜྷᏕࠊྜྷ✀ගࡢ୧ඛ⏕࡟ឤㅰ⏦ࡋୖࡆࡲ࠸㣗ࢫࢱ࢖ࣝ㸦SNS㸧ࢆ☜❧ࡍࡿࡇ࡜ࡀࡇࢀ࠿ࡽࡢㄢ

ࡍࠋ㢟࡛࠶ࡿࠋࣇࣛࣥࢫே⏬ᐙࡢࢻࣛࢡࣟ࢔ࡣࠊࠕ⚾ࡓࡕ

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ཧ⪃ᩥ⊩
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