Form 3
Report for Joint/Usage Research Program for Endocrine/Metabolism(Fiscal Year 2022)
Date：2023/3/30
To Director of Institute for Molecular and Cellular Regulation, Gunma University
Principal ApplicantInstitution

The Hong Kong University of Science and Technology

Position

Assistant Professor

Name

Yukinori Hirano

We report on the results of joint research in fiscal 2022 as below.
（Program No.

22003）

１．Research Title

Study of the transcriptomic and metabolomic variability occurring among aged
individuals in Drosophila

２．Purpose andSignificance of theresearch project

Aging process can be variable between individuals, although underlying mechanisms are unknown. We will investigate how the transcriptome and metabolome are variable in aged individuals using flies as a model organism. This multiomics analysis will suggest an entry point to uncover the mechanisms of theaging variability.

３．Period of The Program

April 1, 2022 ～ March 31, 2023

４．Project Members
Name

Age

Sex

Affiliation

PositionM

The Hong Kong University ofScience and Technology,
Division of Life Science

Position：Assistantprofessor
Degree：PhD
Acquisition date：
2008.3.31

Role（Principal Applicant）

Yukinori Hirano42

Project director（Research Collaborators）※If additional space is required, please attach a separate sheet.
５．Collaborating Researcher Name ofMetabolic Regulationof IMCR
Laboratoryand Genetics

1 / 2Name

Takashi NishimuraInstitute for Molecular andCellular Regulation IMCRGunma University

６． Research Plans
The individual flies will be analyzed to study the correlation between transcriptome and metabolome, whichis related to specific aging phenotype.

７．Research results:
As we found different phenotypic aging phenotypes within the population, we found that subgroup among
the population shows changes in gene expression and metabolome. The obtained results suggest that themetabolome analyses from subgroups of the population can indicate the mechanism underlying specifictypes of aging. The obtained models will be further pursued in the coming collaborative research.

８．Present status of academic conference presentations and research papers associated with the resultsof the joint research, and exchange of information on the joint research with the collaborating researcher atIMCR.
(As much as possible, please state papers that include the names of the collaborating researcher at IMCR
or papers stating that the research was supported by the Joint Research Program with IMCR.
Regarding papers, please send a PDF file together with the report to the email address of the general affairs section of the Institute.) Office of General Affairs: kk-msomu4@jimu.gunma-u.ac.jp① Please list the publications that include the name of the collaborating researcher from IMCR and send a
reprint of each publication to IMCR.

No paper is published yet.
② Please list the publications that include a description that the research was supported by the Joint
Research Program with IMCR and send a reprint of each publication to IMCR.

No paper is published yet.
③List up to 3 conferences (name of conference, date of conference, and title of the presentation).

No presentation in conference yet.
④Exchange of information exchange with collaborating researcher from IMCR (please list main points ofcommunication).

Expertise regarding the sample preparation, and data analyses

2 / 2Institute for Molecular andCellular Regulation IMCR
Gunma University