The 20th Annual Meeting of JSIT
20th Memorial Symposium
Immunotoxicology: Current
Situations and Future
perspective.

〇Jun-ichi Sawada

Pharmaceuticals and Medical
Devices Agency, Tokyo, Japan

Molecular and cellular bases
for chronic inflammation〇Kouji Matsushima
associated organ fibrosis

The Department of MolecularPreventive Medicine, Graduate
School of Medicine, The
University of Tokyo, Tokyo,
Japan

Clinical Evaluation ofImmunotoxicity: Past andCurrent Strategies
Addressing Uncertainty in
Immunotoxicology:
Evaluating Risk for
Immunomodulatory
Comounds

Eurotox Register Toxicologist〇Jacques DESCOTES○Laine Peyton MyersProf. and Head, Poison Centerand Pharmacovigilance
Department, Lyon University
Hospitals, Lyon, France
US Food and Drug
Administration, Silver Spring,
MD, USA

Master’s Lecture 1
Mechanisms of
Immunotoxicity of PAHs andArsenic Given Alone or in
Combination to Murine〇Scott W. Burchiel
Spleen Cells and Human
Peripheral Blood
Mononuclear Cells (HPBMC)

Professor & DeSantis Chair of
Pharmacogenomics,
Department ofPharmaceutical Sciences,
Senior Associate Dean, UNM
HSC College of Pharmacy,
Albuquerque, NM, USA

Master’s Lecture 2
Delta-like 4 is indispensable
in thymic environment
specific for T celldevelopment.

○Katsuto Hozumi

Department of Immunology,
Tokai University School ofMedicine, Japan

Awards Lectures <The JSIT Award>
How to assess exposure andhealth effects among the○Kayama, Fujio
most vulnerable population,
fetus and children

Jichi Medical University,Tochigi, Japan

Awards Lectures <The JSIT Research Award>
Immunotoxicity ofnanomaterials: aiming toestablish sustainable
nanotechnology
Workshop○Yasuo Yoshioka,
Yasuo Tsutsumi

Laboratory of Toxicology andSafety Science, Graduate
School of PharmaceuticalSciences, Osaka University,Suite, Japan

○Yukiko Kanazawa (1),Reiko Adachi (2),(1) PMDA, (2)NIHS, (3)Validation status ofKeratinoSens assay in

Kohichi Kojima (3),Naohisa Tsutsui (4),FDSC, (4)Mitsubishi Tanabe
Pharma Corporation, (5)Fukui

JaCVAM Peer review panel

Kazuhiro Sato (5),University, (6)Sumitomo

on sensitization test

Takashi Morimoto (6),Chemical, (7) CERI, (8)Masahiro Takeyoshi (7), Consultant on Drug Safety
Eiji Maki (8), Hajime
Kojima (2)Assessment, Japan○Masahiro Takeyoshi
Validation status of Direct
Peptide Reactivity Assay(DPRA) in JaCVAM Peerreview panel onsensitization test(1), Kazuhiro Sato (2),Takashi Morimoto (3),(1) CERI, (2) Fukui University,(3) Sumitomo Chemical, (4)Naohisa Tsutsui (4),

Mitsubishi Tanabe Pharma

Reiko Adachi (5),Corporation, (5)NIHS,

Yukiko Kanazawa (6),Kohichi Kojima (7), Eiji
Maki (8), Hajime
Kojima (5)(6)PMDA, (7) FDSC, (8)Consultant on Drug Safety
Assessment, Japan

An example ofimmunotoxicologicalassessment forinvestigational new drugs;○Naohisa Tsutsui
the immunotoxicity studies
for fingolimod, a novel drugfor the treatment of multiple
sclerosis

Mitsubishi Tanabe Pharma
Corporation, JapanOral Presentations〇Hayato Terayama (1),
Miyuki Kuramasu (2),The changes of the immune
Shuichi Hirai (2),circumstance in theMunekazu Naito (2),testicular tissues of mice
Ning Qu (2), Kaori
treated with low doses of diSuyama (1), Masahiro(2-ethylhexyl) phthalate
Itoh (2), Kou Sakabe(1)(1) Department of Human
Structure and Function,
School of Medicine, Tokai
University, Kanagawa, Japan;(2) Department of Anatomy,
Tokyo Medical University,
Tokyo, Japan

Effects of interleukin-6 on
Hitomi Fujishiro, Mari
the transport of manganese Yoshida, 〇Seiichiroin neuronal cellsHimeno

Tokushima Bunri University.
Tokushima, Japan

Effects of isoflavones on IL17 gene expression via
STAT3 and RORγ

Alteration of cytockelton
molecules such as β-actin inhuman T cell line exposedcontinuously to chrysotile(white asbestos)〇Hiroyuki Kojima (1),Ryuta Muromoto (2),Miki Takahashi (2),Shinji Takeuchi (1),
Tadashi Matsuda (2)1Hokkaido Institute of Public
Health, 2Graduate School of
Pharmaceutical Sciences,
Hokkaido University, Sapporo,Japan〇Takemi Otsuki1,
Megumi Maeda2,
Hidenori Mastuzaki1,
Suni Lee1, Naoko
KUmagai-Takei1,Yasumitsu Nishimura1(1)Department of Hygiene,
Kawasaki Medical School,Kurashiki, Japan; (2)Laboratory of Functional
Glycobiochemistry,
Department of BiofunctionalChemistry, Division ofAgricultural and Life Science,
Graduate School ofEnvironmental and Life
Science, Okayama University,Okayama, Japan

(1) WPI Immunology Frontier
Research Center, Osaka
Analysis of particulateinduced pulmonary allergic
inflammation

University、Suit, Japan; (2)〇Etsushi Kuroda (1),Institute of Industrial

Yasuo Morimoto (2)Ecological Sciences, Universityof Occupational andEnvironmental Health,
Kitakyushu, Japan

Study of blood DcR3

〇Suni Lee, YasumitsuNishimura, Shoko

concentration and its

Yamamoto, Tamayo

Kawasaki Medical School,correlation to autoimmune

Hatayama, Hidenori

Dept. Hygiene, Kurashiki,disease parameters inMatsuzaki, Naoko

Japansilicosis patients.

Kumagai-Takei, Takemi
Otsuki

Cadmium exposure
increases the susceptibility
to testicular autoimmunity
in mice〇Yuki Ogawa, Miyuki
Kuramasu, Ning Qu,
Shuichi Hirai, Shogo
Hayashi, Naoyuki
Hatayama, Munekazu
Naito, Masahiro Itoh

〇Tomonori Hayashi(1), Yiqun Hu (1), Kyoji
Age, smoking, and radiation
Furukawa (2), Wakaeffects on the production ofOhishi (3), Ikue
reactive oxygen species inHayashi (4), Kengo
blood cells of atomic-bombYoshida (1), Junkosurvivors
Kajimura (1), Seishi
Kyoizumi (1), Yoichiro
Kusunoki (1), Kei
Nakachi (1)Forming agglomerate with
antigen make silica
nanoparticle immunotoxic.

Department of Anatomy,
Tokyo Medical University,Tokyo, Japan

Departments of (1)Radiobiology/Molecular
Epidemiology, (2) Statistics,and (3) Clinical Studies,
Radiation Effects Research
Foundation; (4) Hiroshima
University Faculty ofDentistry, Hiroshima, Japan○Toshiro Hirai (1),Yasuo Yoshioka (1),
Hideki Takahashi (1),
Ko-ichi Ichihashi (1),Nobuo Nishijima (1),Tokuyuki Yoshida (1),(1) Grad. Sch. Pharm. Sci.,
Osaka Univ.; (2) NIBIO;
Ibaragi, Japan; (3) MEIC,

Shin-ichi Tsunoda (2),(3), Kazuma

Osaka Univ., Suita, Japan

Higashisaka (1), Yasuo
Tsutsumi (1), (2), (3)Immunological and○Young-Man Cho (1),Reiko Adachi (2),(1) Div. Path., Natl. Inst.
Health Sci., Tokyo, Japan; (2)histopathological analysis of Shinobu Sakai (2),Div. Novel Foods
BALB/c mice
Yoshie Kimura (2), Rika Immunochem., Natl. Inst.
transcutaneously sensitizedwith acid-hydrolyzed wheat

Nakamura (2), Yuma
Fukutomi (3), Reiko

Health Sci., Tokyo, Japan; (3)Clin. Res. Ctr. Allergy

proteinTeshima (2), Kumiko
Ogawa (1)Rheumatol., Sagamihara Natl.
Hosp., Kanagawa, Japan

Impact of topicalcorticosteroids potency on○Katsunori Yamaura,
Ayaka Funakoshi,

scratching behavior ofsteroid-induced pruritus inmice

Nobuo Oishi, AyanaTomono, Ryosuke Doi,Koichi Ueno

Depertment of GeriatricPharmacology andTherapeutics, Graduate
School of PharmaceuticalSciences, Chiba University,CHIba, Japan

Application of h-CLAT as aprediction test of druginduced allergy○Maho Ukaji (1),(1) Div. Med. Safety Sci., Natl.
Ryosuke Nakamura (1), Inst. Health Sci.; (2) Phar.
Yoshiro Saito (1),
Mitsuhiro Uchida (2),Res. Ctr., Meiji Seika Pharma,
Co. Ltd.; (3) Dpt. Food Sci.

Toshiyuki Tsuchiya (2),Kouichi Kurose (1), (3)Tech., Tokyo Univ. Marine Sci.,
Tokyo, Japan

Sensitization study by a new
qualitative structure-toxicity ○Kazuhiro Sato (1),relationships (QSTR)
Yukinori Kusaka (1),approach: K-step Yard
sampling (KY) methods

Development the identifying
method for chemicalinduced respiratory allergy

Effects of combined
exposure to environmental
immunotoxicologicalchemicals

Kohtaro Yuta (2)(1) Department ofEnvironmental Health, Schoolof Medicine, University ofFukui, Fukui, Japan, (2) In
Silico Data Ltd., Narashino,Japan○Risako Nishino,
Tomoki Fukuyama,
Yuko Watanabe,
Yoshimi Kurosawa,

Institute of Environmental
Toxicology, Ibaraki, Japan

Hideo Ueda, Tadashi
Kosaka○Tomoki Fukuyama,
Risako Nishino, Tadashi
Kosaka, ,Yuko
Watanabe, Yoshimi
Kurosawa, Koichi
Hayashi, Hideo Ueda,

Institute of Environmental
Toxicology, Ibaraki, Japanand Takanori Harada

Acid-hydrolyzed wheat
protein-specific serum IgEcross-reacts to transglutaminase-treated wheat
gluten○Ryosuke Nakamura(1), Rika Nakamura (1), (1) Natl. Inst. Health Sci.,
Shinobu Sakai (1),Tokyo, Japan; (2) 2nd
Reiko Adachi (1),Teaching Hosp., Fujita HealthYoshiro Saito (1), Atsuo Univ., Nagoya, Japan; (3)Clin.
Urisu (2), Yuma
Fukutomi (3), ReikoRes. Ctr., Sagamihara Hosp.,
Sagamihara, JapanTeshima (1)(1)Environmental Health
Division, Department ofEnvironmental Engineering,
Graduate School ofEngineering, Kyoto University,
Streamer discharge reduces
cedar pollen-induced proinflammatory responses inhuman airway epithelialcells.

○Akiko Honda (1),Kyoto, Japan; (2)Departmentof Anatomy and Structural

Nobuyuki Shirasawav
Science, Yamagata University(2), Satoshi Ozawa (3), Graduate School of Medical
Yoshio Okamoto (4),Science, Yamagata, Japan;
Hirohisa Takano (1)(3)Technology and Innovation
Center Preparation Office, (4)Air Conditioning
Manufacturing Division
Product Development Group,
Daikin Industries, LTD. Osaka,JapanRole of transcription factor○Hidenori Mastuzaki(1) Department of Hygiene,

FoxO1 in regulation ofapoptosis induced by(1), Suni Lee (1),Megumi Maeda (2),Kawasaki Medical School,
Kurashiki, Japan;

asbestos.

Naoko Kumagai-Takei(1), Yasumitsu(2)Laboratory of Functional
Glycobiochemistry,

Nishimura (1), Takemi

Department of Biofunctional

Otsuki (1)Chemistry, Division ofAgricultural and Life Science,
Graduate School ofEnvironmental and Life
Science, Okayama University,
Okayama, Japan

Toxicity characteristics of○Yasumitsu Nishimura(1), Daisuke Yoshioka(1) Dept of Hygiene and (2)titanate nanosheets forperipheral blood(2), Suni Lee (1),Naoko Kumagai-Takei

Dept of natural sciences,
Kawasaki Medical School,mononuclear cells(1), Hidenori Matsuzaki(1), Takemi Otsuki (1)Kurashiki, Japan○Naoko KumagaiEffect of IL-2 addition on the Takei, Yasumitsu

Department of Hygiene,

suppressed induction of CTL Nishimura, Hidenori
upon exposure to asbestos Matsuzaki, Suni Lee,

Kawasaki Medical School,
Kurashiki, Japan

Takemi Otsuki
Reversible changes ofneurological andinflammatory biomarkers inthe mouse hippocampus
after early life exposure tointermediate frequency
magnetic fields(1) National Institute for○Tin Tin Win Shwe (1),Environmental Studies,Shin Ohtani (2), Akira
Tsukuba, Ibaraki, Japan; (2)Ushiyama (2), Hiroshi
National Institute of Public
Nitta (1), Naoki
Health, Wako City, Saitama,
Kunugita (2)Japan

Mechanisms of the effects of○Eiko Koike (1), Rie
brominated flame
Yanagisawa (1),retardants on bronchial
Hirohisa Takano (2)epithelial cells(1) National Institute forEnvironmental Studies,
Tsukuba, Japan; (2)Kyoto
University, Kyoto, Japan

Emiko Sugiyama (1),(2), Nahoko Kaniwa(1),(2), Yukitoshi
Takahashi (2), Hirokazu
Furuya (2), Masaaki
Muramatsu (2), Shigeru
Associations between HLAKinoshita (2), Taisei
alleles and severe cutaneous Mushiroda (3), Michiaki(1) Natl. Inst. Health Sci.,
Tokyo, Japan; (2) JSAR

adverse reactions inducedby 3 anti-epileptic drugs inKubo (3), Keiko
Maekawa (1),(2),research group, Japan; (3)Riken, 4Japan; (4) JPDSC

Japanese patients.

Ryosuke Nakamura (1), (the Japan(2), Akiko Yagami (2),Pharmacogenomics Data
Chie Sotozono (2),Science Consortium), JapanMayumi Ueta (2),Hiroko Ikeda (2), ZenroIkezawa (2), JPDSC(4), Kayoko Matsunaga(2), Michiko Aihara (2),
○Yoshiro Saito (1),(2)The effect of aspirin on IgE- ○Masae Horii (1),dependent basophil
Yuma Fukutomi (2),(1) Department ofEnvironmental and Preventiveactivation

Tomoko Toma (3),Tomomi Higashi (4),Medicine, Kanazawa
University, Kanazawa, Japan;

Masami Kitaoka (1),Junko Mitoma (1),(2) Sagamihara National
Hospital, Sagamihara, Japan;

Hiroki Asakura (1),(3) Department of Pediatrics,

Yasuhiro Kambayashi

Kanazawa Univ., 4Department(1), Yoshiaki Hitomi(1), Akihiro Yachie (3),of Hygiene, Kanazawa Univ.,
Kanazawa< Japan

Hiroyuki Nakamura (1)Students and Young Scientists Session〇Nobuo Nishijima (1),Size-independent

Yasuo Yoshioka (1),Toshiro Hireai (1),(1) Grad. Sch. Pharm. Sci.,

immunotoxicity induced byamorphous silica particles

Hideki Takahashi (1)Ko-ichi Ichihashi (1),Osaka Univ., Suita, Japan;(2), NIBIO, Ibaragi, Japan;

Shin-ichi Tsunoda (2),(3), Kazuma(3) MEIC, Osaka Univ., Suita,Japan

Higashisaki (1), YasuoTsutsumi (1),(2),(3)〇Yoshie Hirayanagi,
The effect of busulfan on
the immune system andspermatogenesis in
immune-competent mice

Ning Qu, Shuichi Hirai,
Munekazu Naito, Miyuki Department of Anatomy,
Kuramasu, Shogo

Tokyo Medical University,Hayashi, Naoyuki
Tokyo, Japan
Hatayama and Masahiro
Itoh

The inflammatory relative
mRNA expressions ofChemokine in splenicmacrophages from rats
exposed to MWCNT bywhole-body inhalation for
13 weeks〇Takamasa Kido (1),(2), Masashi Tsunoda(2), Tatsuya Kasai(3),Toshiaki Sasaki (3),(1) Department of PublicHealth and Environmental
Medicine, The Jikei University
School of Medicine, Tokyo,Japan; (2) Department ofPreventive Medicine, Kitasato

Yumi Umeda (3), Hideki
University School of Medicine,Senoh (3), Hiroyuki
Sagamihara, Japan; (3)Japan
Yanagisawa (1),Bioassay Research Center,
Masumi Asakura (3),Japan Industrial Safety andYoshiharu Aizawa (4),Health, Tokyo, Japan; (4) The
Shoji Fukushima (3)Kitasato, Insitute, Tokyo,
Japan

Luncheon Seminar
Immune Endpoints and〇Christina M.
their Relevance to Preclinical
Satterwhite
Toxicology
Advances in the predictionof cytokine release
syndrome○K HarperDirector, Laboratory Sciences,
Charles River Laboratories,
Preclinical Services, Nevada,USA
Huntingdon Life Sciences,
Huntingdon, UK