5-Ph-IAA: Inducer for Auxin Inducible Degron 2 System30-003

10 mg

30-003-10

100 mgShipping and Storage: Ship at ambient temperature or at 4 °C or below. Make stocksolution, aliquot and store at ‒20 °C or below.
Stock solution: Make 100mM stock solution by resolving 10 mg 5-Ph-IAA in 400 μL
solvents, such as DMSO and store the stock solution at ‒20 °C for a year or at -80℃ forlonger period.
Usage: 5-Ph-IAA induces degradation of degron-fused protein in Auxin Inducible Degron
2 system. For inducing degradation in cell culture, use a stock solution dissolved inDMSO. 5-Ph-IAA typically works at less than 1 µM. For mice, use a 5-Ph-IAA solution
dissolved in PBS. It typically works less than 10 mg/kg by intraperitoneal injection.
For detail protocol, see Reference.
Product name:5-Ph-IAA

Chemical name:5-Phenyl-1H-indole-3-acetic acid

CAS Registry Number:

168649-23-8

Chemical Formula:

C16H13NO2

Molecular Weight:

251.28Purity:＞98％ as determined with HPLC

Molecular structure of 5-Ph-IAA, Inducer for Auxin Inducible Degron 2 system

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Patents: The use of this material in the “Auxin-Inducible Degron System” is subject topatent technology held by the Research Organization of Information and Systems,
NATIONAL INSTITUTE OF GENETICS (NIG/ROIS) and Kake Educational
Institution (KEI), and the researchers in profit companies must obtain the license from
NIG/ROIS and KEI.

Contact : chizai@nig.ac.jp(NIG INNOVATION, National

Institute of Genetics, Japan)
Reference (Protocol)
Yesbolatova A et al. The Auxin-Inducible Degron 2 technology provides sharp
degradation control in yeast, mammalian cells, and mice. Nat Commun. 2020 11: 5701.
PMID: 33177522
This product is to be used for research purpose only, not in human.

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Tel. 81-6-6877-2335

Fax. 81-6-6877-2336

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MATERIAL SAFETY DATA SHEET
1. IDENTIFICATION
Product name:5-Ph-IAA

Chemical name: 5-Phenyl-1H-indole-3-acetic acid
Product code:30-003. 30-003-10

Supplier:

BioAcademia Inc.

Address:

North Buiding, Research Institute for Microbial Diseases, Osaka

University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Telephone: 81-6-6877-2335

Fax: 81-6-6877-2336

E-mail: info@bioacademia.co.jp
2. HAZARDS IDENTIFICATIONClassification of the substance or mixture: Substance
PHYSICAL HAZARDS:

Not classified

HEALTH HAZARDS:

Not classified

ENVIRONMENTAL HAZARDS:

Not classified

Label elements
Pictograms or hazard symbols:

None

Signal word:

No signal word

Hazard statements:

None

Precautionary statements:

None

3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:

Substance

CAS Registry Number:

168649-23-8

Chemical Formula:

C16H13NO2

Molecular Weight:

251.28

Notice Through Official Gazettes Reference Number
ENCS: Not Listed
4. FIRST-AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable forbreathing. Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin withwater/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. If eye irritation persists: Get medicaladvice/attention.
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Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as
rubber gloves and air-tight goggles.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Dry chemical, foam, water spray, carbon dioxide.
Specific hazards arising from the chemical: Take care as it may decompose upon
combustion or in high temperatures to generate poisonous fume.
6. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing
7. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers
should not be exposed directly. Also install safety shower and eye bath
Control parameters: Not set up
Personal protective equipment
Respiratory protection:

Dust respirator. Follow local and national regulations.

Hand protection:

Protective gloves.

Eye protection:

Safety glasses.

Skin and body protection:

Protective clothing.

8. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):

SolidForm:

Crystal- Powder

Color:

Colorless to Pale yellow.

Odor:

No data available

pH:

No data available

Flammability or explosive limits:
Lower:No data available

Upper:No data available

Relative density:

No data available

Solubility(ies): [Water] No data available,[Other solvents] Soluble: methanol, acetone, DMSO, DMF

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9. STABILITY AND REACTIVITY
Chemical stability:

Stable under proper conditions.

Possibility of hazardous reactions:

No special reactivity has been reported.

Incompatible materials:

Oxidizing agents

Hazardous decomposition products:

Carbon monoxide, Carbon dioxide, Nitrogenoxides (NOx)
10. TOXICOLOGICAL INFORMATION
Acute Toxicity:

No data available

Skin corrosion/irritation:

No data available

Serious eye damage/irritation:

No data available

Germ cell mutagenicity:

No data available

Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity:

No data available

11. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish:

No data available

Crustacea:

No data available

Algae:No data available

Persistence / degradability:

No data available

Bioaccumulative potential(BCF): No data available
Mobility in soil
Log Pow:

No data available

Soil adsorption (Koc):

No data available

Henry's Law

No data available

constant(PaM3/mol):
12. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able
to dissolve or mix material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal,state and local regulations when disposing of the substance.
13. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed
BioAcademia,Inc.

Tel. 81-6-6877-2335

Fax. 81-6-6877-2336

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14. REGULATORY INFORMATIONNo chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302, or have known CAS numbers that exceed the threshold reporting levels
established by SARA Title III, Section 313.
15. OTHER INFORMATIONThis MSDS is correct to the best of our knowledge at the date of publication but does
not purport to be all inclusive and shall be used only as a guide. It must only be handled
by suitably qualified experienced scientists in appropriately equipped and authorizedfacilities. The burden of safe use of this material rests entirely with the user.
Bioacademia Inc. shall not be held liable for any injury or damage resulting fromhandling or from contact with the above product.
This product is to be used for research purpose only, not in human.

BioAcademia,Inc.

Tel. 81-6-6877-2335

Fax. 81-6-6877-2336

info@bioacademia.co.jp

https://www.bioacademia.co.jp/en/