Welcome toKeio University School of Medicine
Masayuki Amagai, MD, PhD
Dean, Keio University School of Medicine
Professor and Chair, Department of Dermatology

Copyright © 2006 Keio UniversityApril14, 2018

National Academy of Medicine (NAM)
Induction Ceremony for New Members

2017/10/14
Washington DCKeio University is Japan’s First Modern Institutionof Higher Education
Years in which Major Japanese Universities were Founded
Private universities

National universities

Yukichi Fukuzawa: the Founder of Keio University who is a visionary andintellectual leader.
Kanrin-Maru (Shipto the US)
members in 1860.
Fukuzawa at thefar right.
(Source: The Eastern Culture Association)

Founder Yukichi Fukuzawa and the 10,000 yen Banknote

Facts and Figures

Japan’s First Modern
Institution of Higher
Learning

Countries &Regions
Represented
in Our Student
Body

Undergraduate
Faculties

Degree Programs
Offered in English

Graduate
Schools

Double Degree
Programs

Full-time
University Faculty
members

Almuni worldwide

Student-to-faculty
Ratio

Prime Ministers

Astronauts

Top Global University Project
Keio was selected as one of the 13 Top research universities for the Top Global
University Project by the government in 2014 and will be receiving financial support
for a maximum of 10 years.
Keio has formed the research and educational initiatives of Longevity, Security,
and Creativity as its own Global Initiatives.
Keio established Keio Global Research Institute (KGRI) to showcase and facilitate
interdisciplinary research under the three initiatives in 2016.

Longevity
Initiative to realize
a society wherepeople live better,longer lives

Creativity
Integrative
Approaches

Security
Initiative to assure a safer, moresustainable society

Initiative tobolster innovationin education andresearchOur Founding Philosophy
PHYSICIAN SCIENTIST
Physicians equipped with theresearch capabilities necessary topractice patient-oriented care.
Shibasaburo Kitasato

Yukichi Fukuzawa

The goal of our medical education is to “preventsectionalism in medicine, and strengthen the connection
between basic medical science and clinical medicine” inorder to train doctors who possess the spirit of bothbasic and clinical medicine based on science.

1917: The founding spirit of Keio University School of Medicine and Hospital“to realize the unification of basic medical science and clinical medicine”
remains vibrant despite natural disaster and war.
19171945

2001

1948

1958

New Hospital Building as Centennial Project(May 7, 2018 open)

New National
Stadium74,609 m2
The ground 11 floor / basement second floor
Earthquake Proof (Quake-absorbing structure)
800 beds for inpatients
80% of outpatient clinic
27 operation rooms

Shinnanomachi
StationNew Hospital Building
March, 2018

New Hospital Building
Nov, 2017

Shinnanomachi
StationMedical Street

Cafe Lounge Forest

Outpatient Reception

From bench to bed, and from bed to bench
PET-CT-PET Development

Hybrid Operating Room

Preventive Medicine Center
Immunotherapy Center

Early Detection Facilities

From bench to bed

From bed to bench

Laparoscopic Sentinel Lymph Node Biopsy

Center for Integrated Medical Research(Regenerative・CPC・Centenarian）

International Collaboration
On-line lecture series to belaunched in October 2018 following
the Keio-Cologne Symposium inFebruary

Global University Leaders Forum2018
at World Economic Forum

Experience Japan Exhibition at the Royal
Society London in November 2017

Japan-Korea Millennium
Forum in October 2017

Collaboration with Yokohama andKawasaki Cities to host the Team GB
Preparation Camp for Tokyo 2020
Olympic GamesThe Keio Medical Science Prize
Prize Laureates（Nobel Prize Winner in red)
1996- Stanley B. Prusiner and Shigetada Nakanishi
1997- Robert A. Weinberg and Tadatsugu Taniguchi
1998- Moses Judah Folkman and Katsuhiko Mikoshiba
1999- Elizabeth Helen Blackburn and Shinya Yoshikawa
2000- Arnold J. Levine and Yusuke Nakamura
2001- Tony Hunter and Masatoshi Takeichi
2002- Barry Marshall and Koichi Tanaka
2003- Ronald M. Evans and Yasushi Miyashita
2004- Roger Y. Tsien
2005- Yoshinori Fujiyoshi
2006- Thomas A. Steitz
2007- Brian J. Druker and Hiroaki Mitsuya
2008- Fred H. Gage and Shimon Sakaguchi
2009- Jeffrey M. Friedman and Kenji Kangawa
2010- Jules A. Hoffmann and Shizuo Akira
2011- Philip A. Beachy and Keiji Tanaka
2012- Steven A. Rosenberg and Hiroyuki Mano
2013- Victor R. Ambros and Shigekazu Nagata
2014- Karl Deisseroth and Hiroshi Hamada
2015- Jeffrey I. Gordon and Yoshinori Ohsumi
2016- Svante Pääbo and Tasuku Honjo
2017- John E. Dick and Seiji Ogawa

Gut microboita and Immune system
Linked development of T cell subsets with bacteria strains in gut.
Kenya Honda

Lamina propria

CD8 T cells
Bacteria oforal origin(Atarashi,Science 2017)20 strains ofhuman bacteria(Atarashi,Cell 2015)

IgA+ cells

TH1 cells
TH17 cells
SFB(Ivanov, Atarashi
Cell 2009 )ILCs

Foxp3+
Treg cells

46 strains ofmouse Clostridia(Atarashi, Science2011)17 strains ofhuman Clostridia(Atarashi, Nature 2013)

Development of organoid technology to assess
biological functions of human tissues
Human tissues innormal/cancer

Organoids
Drug susceptibility
Live imaging
Genetic perturbation
Tumorigenic assay

In vitro transformation of human colon organoids+KRASG12V+APC KO

Toshiro Sato
Sato T, Clevers H et al.
Nature 2009, 2011
Matano M et al. Nature Med 2015

+SMAD4 KO+TP53KO

Human normalcolon organoids

Engineered coloncancer organoids

Visualization of human normal/cancer stem cells in tissue environments
Human Normal Colon

Human Colon Cancer
Shimokawa M et al. Nature 2017

Day3Day6Day28

Day3Day10Day28

Sugimoto S et al.
Cell Stem Cell 2018

Minimally invasive surgery with endoscopic andlaparoscopic approaches for gastric cancer

Yuko Kitagawa(Surgery)

Total gastrectomy

Minimum surgery

Antigen-specific therapeutic strategies using
peripheral tolerance for autoimmune diseases
Pemphigus : IgG-mediated autoimmune disease to skin

Bone Marrow (BM)Dsg3-specific TcellsThymus
Dsg3-Masayuki Amagai(Dermatology)Periphery (LN, Skin)
Dsg3+

Deletionfirst check pointsecond check point