Curriculum vitae
Jun-ichi Sawada, Doctor of Engineering

Personal:
Affiliation:

Center for Drug Discovery,
School of Pharmaceutical Sciences, University of Shizuoka

Position:

Associate Professor

Mailing address:52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan

E-mail address:

jisawada@u-shizuoka-ken.ac.jp

Telephone & Fax: +81-54-264-5230
Date of Birth:

February 13, 1970

Nationality:

Japan by birth

Gender and Marital status: Male & married

Current research fields:
Chemical screening for mitotic inhibitors
Chemical biology in mitotic regulation of cell cycle

Education:
Doctor of Engineering,

Graduate School of Bioscience and Biotechnology,
Tokyo Institute of Technology, held in 1997
Supervised by Dr. Hiroshi Handa

Master of Engineering,

Graduate School of Bioscience and Biotechnology,
Tokyo Institute of Technology, held in 1994

Bachelor of Engineering, Faculty of Engineering,Tokyo Institute of Technology, held in 1992

Position:
Apr. 1997 to Jul. 1997

Postdoctoral fellow of Prof. Handa’s Lab.,Tokyo Institute of Technology Research
fellow of Prof. Suzuki’s Lab., National
Institute for Basic BiologyAug. 1997 to Mar. 1998 Research officer of Venture Business Lab.,Tokyo Institute of Technology
Apr. 1998 to Mar. 2001

Research fellow of the Japan Society for the promotion ofScience, Prof. Handa’s Lab., Frontier Collaborative ResearchCenter, Tokyo Institute of Technology

Jan. 2000 to May 2004

Postdoctoral fellow of Prof. Nakatani’s Lab.,
Dana-Farber Cancer Institute, Harvard Medical School

Jun. 2004 to Present

Associate Professor, Center for Drug Discovery
University of Shizuoka

Selected publications:1.

Carbajales C, Sawada J, Marzaro G, Sotelo E, Escalante L, Marta A SD, GarciaMera X, Asai A, Coelho A. 2017. “Multicomponent assembly of the Kinesin Spindle
Protein inhibitor CPUYJ039 and analogues as antimitotic agents.” ACS Comb.

Sci. 19: 153–160.
2.

Sawada J, Osawa A, Takeuchi T, Kaneda M, Oishi S, Fuji N, Asai A, Tanino K,Namba

K. 2016.

“Functional

1,3a,6a-triazapentalene

scaffold: Design offluorescent probes for kinesin spindle protein (KSP).” Bioorg. Med. Chem. Lett.
26: 5765–5769.
3.

Ogo N, Ishikawa Y, Sawada J, Matsuno K, Hashimoto A, and Asai A. 2015.
“Structure-guided design of novel L-cysteine derivatives as potent KSP inhibitors.”

ACS Med. Chem. Lett. 6: 1004–1009.
4.

Yokoyama H#, Sawada J#, Katoh S, Matsuno K, Ogo N, Ishikawa Y, Hashimoto H,Fujii S, and Asai A. 2015. “Structural basis of new allosteric inhibition in Kinesin
spindle protein Eg5.” ACS Chem. Biol. 10: 1128–1136.

5.

Takeuchi T, Oishi S, Kaneda M, Ohno H, Nakamura S, Nakanishi I, Yamane, M,
Sawada J, Asai A, and Fujii N. 2014. “Kinesin spindle protein inhibitors withdiaryl amine scaffolds: Crystal packing analysis for improved aqueous solubility.”ACS Med. Chem. Lett. 5: 566–571.
6.

Ohno K, Sawada J, Takiya S, Kimoto M, Matsumoto A, Tsubota T, Uchino K, HuiCC, Sezutsu H, Handa H, and Suzuki Y. 2013. “Silk gland factor-2, involved infibroin gene transcription, consists of LIM homeodomain, LIM-interacting, andsingle-stranded DNA-binding proteins.” J. Biol. Chem. 288: 31581–31591.

7.

Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K, Asai A,
Asada N, Kitaura K, Fujii N. 2011. “Structure-Activity Relationships ofCarboline and Carbazole Derivatives as a Novel Class of ATP-Competitive
Kinesin Spindle Protein Inhibitors.” J. Med. Chem. 54, 4839-4846.
8.

Oishi S, Watanabe T, Sawada J, Asai A, Ohno H and Fujii N. 2010. “Kinesin
spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.” J. Med. Chem.
53, 5054-5058.

9.

Oikawa T, Unno Y, Matsuno K, Sawada J, Ogo N, Tanaka K, Asai A. 2010.
“Identification of a small-molecule inhibitor

oftheinteraction

between

Survivin and Smac/DIABLO.” Biochem. Biophys. Res. Commun. 393, 253-258.
10. Matsuno K, Sawada J, Sugimoto M, Ogo N and Asai A. 2009. “Bis(hetero)aryl
derivatives as unique kinesin spindle protein inhibitors.” Bioorg. Med.

Chem. Lett. 19: 1058-1061.
11. Ogo N, Oishi S, Matsuno K, Sawada J, Fujii N and Asai A. 2007. “Synthesisand biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5inhibitors.” Bioorg. Med. Chem. Lett. 17: 3921-3924.
12. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev
AF, Tanaka K and Nakatani Y. 2003. “The ubiquitin ligase activity in theDDB2 and CSA complexes is differentially regulated by the COP9 signalosome
in the response to DNA damage.” Cell. 113: 357-367.
13. Shi Y, Sawada J, Sui G, Affar EB, Whetstine JR, F. Lan, H. Ogawa, M. P.-S.
Luke, Y. Nakatani and Y. Shi. 2003. “Coordinated histone modification
mediated by a CtBP co-repressor complex.” Nature. 442: 735-738.
14. Sawa C, Yoshikawa T, Matsuda-Suzuki F, Delehouzee S, Goto M, Watanabe H,Sawada J, Kataoka K and Handa H. 2002. “YEAF1/RYBP and YAF-2 arefunctionallydistinct membersofaco-factor

familyfortheYY1andE4TF1/hGABP transcription factors.” J. Biol. Chem. 277: 22484-22490.
15. Tomohiro T, Sawada J, Sawa C, Nakura H, Yoshida S, Kodaka M, Hatakeyama M,Kawaguchi H, Handa H, and Okuno H. 2002. “Total analysis and purification ofcellular proteins binding to cisplatin-damaged DNA using submicron beads.”

Bioconjugate Chem. 13: 163–166.
16. Sawada J, Shimizu N, Suzuki F, Sawa C, Goto M, Hasegawa M, Imai T,Watanabe H and Handa H. 1999. “Synergistic transcription activation byhGABP and select members oftheactivationtranscription

factor/cAMP

response element-binding protein family.” J. Biol. Chem. 274: 35475-35482.
17. Suzuki F, Goto M, Sawa C, Watanabe H, Sawada J and Handa H.. 1998.
“Functional interactions of transcription factor hGABP subunits.” J. Biol.

Chem. 273: 29302-29308.
18. Sawa C, Goto M, Suzuki F, Watanabe H, Sawada J and Handa H. 1996.
“Functional domains of transcription factor hGABP/E4TF1-53 required fornuclear localization and transcription activation.” Nucleic Acids Res. 24:4954-4961.
19. Sawada J, Goto M, Sawa C, Watanabe H and Handa H. 1994. “Transcriptionalactivation through the tetrameric complex formation of E4TF1 subunits.”

EMBO J. 13: 1396-1402.
20. Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M and Handa H. 1993.
“cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch
motifs.” Mol. Cell. Biol. 13: 1385-1391.