IMMUNOTOXICOLOGYSpecialty Section
Pre-SOT Edition
2018-2019
Executive Committee
President
Jamie DeWitt
Vice President
Emanuela Corsini

President’s Message
Are you all ready to be “charmed” by another SOT Annual Meetingin Baltimore, MD (the “Charm City”)? The 58th Annual Meeting andToxExpo will be held at the Baltimore Convention Center, which is
downtown and next to the Inner Harbor and Little Italy districts. If
you haven‟t yet registered, you may still do so, although the
reduced registration fee deadlines have passed. This link will takeyou to the SOT registration page. If you plan to attend and haven‟t
yet registered, please remember to do so!

Vice President-ElectMark Collinge

Immunotoxicology is featured in two of the Continuing Education
programs on Sunday, 3/10/19. An AM session focuses on
Secretary/Treasurer
Mechanistic Understanding and Quantitative Risk Assessment in
Stacey Anderson
Immunotoxicology and a PM session on the Microbiome andEnvironmental Toxicants has a session on the current state-of-thePast President
science of the microbiome in immunotoxicology. Other sessions
Vic Johnson
sponsored by the ITSS are highlighted later in the newsletter. Thesesessions would not be possible without the hard work of ourSenior Councilor
Program Committee, which is chaired by Emanuela Corsini, andJessica Lynch
those of you from the ITSS membership and beyond who submitted
session proposals for endorsement by the ITSS and consideration
Junior Councilor
by the Scientific Program Committee (SPC). If you have an ideathat‟s been simmering or want to highlight an area that you think has
Jennifer Wheeler
been underrepresented at Annual Meetings in past years, consider
Postdoc Representative
submitting a session proposal. A range of sessions are available,
Alessandro Venosa
including the more traditional Continuing Education, Roundtable,
Symposia, and Workshop formats as well as Education-Career
Student Representative
Development, Historical Highlights, and Regional Interest sessions.
Alexa Murray
Please feel free to contact any one of the current Executive
Committee members to get the ball rolling or reach out to MarkThe Immunotoxicology Specialty Section
Collinge, who will chair the Program Committee in 2019-2020. But,
(ITSS) Newsletter is published twice a year
most importantly, tag those Immunotoxicology sessions in your(Summer and Winter). If you would like tomeeting agenda and attend to show support for yourshare an item of interest with members of
the ITSS, please send it to the
Immunotoxicology colleagues!
Communications Committee Chair. Allcomments and suggestions are welcome.

Alessandro Venosaavenosa@pennmedicine.upenn.edu
Alexa Murrayalexa.murray18@gmail.com
Jennifer Wheeler
jewheeler@celgene.com

February 2019

President‟s Message…….……..…………………………………..…….1
ITSS Program at SOT.........................................................................3
Student Post-doctoral Report. ……............................…….....….……6
Member Spotlight.......................………..............….…….......….........7
Networking/Mentoring Announcement.............................................11
Report from JSIT..................….........................................................12
Endowment Fund Update……...........................................................14
Recent Immunotoxicology Publications............................................15
Immunotoxicology Membership Achievements and Awards……......19
1

Immunotoxicology Specialty Section

President’s Message (Continued)
Students, postdocs, and other trainees, don‟t forget to add the ITSS Networking and Mentoring Event toyour meeting agenda for the Annual Meeting. This year it will be held on Wednesday, March 13 from 4:155:45pm in the Hilton Baltimore, room Key 9.
The ITSS Meeting and Reception also will take place on Wednesday, March 13 from 6-7:30pm and will also
be held in the Hilton Baltimore, room Key 9. Please attend to catch up with your colleagues, meet newcolleagues, hear about ITSS business, congratulate our 2019 award winners, and meet the 2019-2020
ITSS Executive Committee!
Speaking of awards and elections, even though the deadlines for both have passed, thank you to those of
you who took time to nominate trainees and colleagues for the various awards and Executive Committee
positions and to vote in the ITSS Executive Committee elections. We all appreciate the time and effort that it
takes to nominate someone for an award or a position. We also understand that there are still a few issues
with some ITSS members not receiving ballots and are working with SOT to try to resolve these issues.

I would also like to introduce you all to Mina Klier, the new SOT Liaison to theSpecialty Sections & Awards Committee. She has stepped up to fill the shoes ofRaul Suarez, who shifted his career to another organization earlier this year. We
are saddened to lose the wisdom and experience that Raul brought to thisposition, but are excited to be working with Mina. Welcome Mina!

We look forward to seeing you in March and as usual, if you have any questions, concerns, or suggestions,please feel free to reach out to any member of the ITSS Executive Committee.
Best regards,
Jamie DeWitt, PhD
East Carolina University
President ITSS

February 20192

Immunotoxicology Specialty Section

ITSS Programs at SOT 2019
Please contribute a program proposal
for the SOT 2020 Annual Meeting!
Dear members of the ITSS,
For the 2019 Annual Meeting, the ITSS endorsed twocontinuing education courses on "Mechanistic
Understanding and Quantitative Risk Assessment
in Immunotoxicology" and "Microbiome andEnvironmental Toxicants: From Study Design andAnalysis to Regulatory Guidance." We look forward
to seeing you at these events!!
We need your contributions and new ideas for attractive and winning roundtables, workshops,
symposia, and continuing education programs (the competition is very robust)! Your active participation in theSpecialty Section is vital for the section itself. Please start thinking about what topics you would like to see atthe 2020 Annual Meeting (it‟s never too early to start planning!) and lead the team of presenters for that
topic! Send your proposals to the ITSS Program Committee Chair, Emanuela Corsini(emanuela.corsini@unimi.it) by April 15th, 2019, so that we may help you to submit the most competitive
proposal possible.
SOT is already gearing up for the 2020 Annual Meeting. In addition to the canonical 165-minutesessions, the upcoming meeting will host 90-minute sessions followed by 30-minute breaks to allow for
individuals to follow up with speakers or networking with session attendees. Detailed directions fordeveloping and submitting proposals will be available in the near future, so look for an email from us via
SOT shortly after the 2019
Annual Meeting. In order foryour proposal to be reviewed forendorsement by ITSS, please submit your title and abstract to Mark Collinge (Mark.Collinge@pfizer.com),by the ITSS internal deadline of April 15th. This will allow ITSS Program Review Committee time toprovide feedback and get ITSS endorsement prior to the SOT deadline of May 15.
ADVICE: please consider the following steps as you prepare your proposals:•The session presentations should be designed to provide a cohesive thread throughout the session.
•The session should address a topical issue of broad general relevance, rather than a narrow topic of highinterest to fewer scientists.
•The session presenters should reflect a diversity of opinions/backgrounds to reflect perspectives fromindustry/regulators/academics.
•CE courses have a better chance of acceptance, as do roundtables – think about these formats as apossibility.
Don't miss the opportunity to contribute to a program by submitting yourscientific proposal! Thank you in advance for your continuous
support and contribution. We look forward to receiving your proposal!

Program Committee
Outgoing Chair: Emanuela Corsini
Weimin Chen
Incoming Chair: Mark Collinge
Peer Karmaus
Cheryl Rockwell
Tracey Papenfuss
Sarah Blossom
Nada Alakhras
Ashwini Phadnis-Moghe
February 20193

Immunotoxicology Specialty Section

ITSS Programs at SOT 2019 (Continued)
Continuing Education
Mechanistic Understanding and Quantitative Risk Assessment in
Immunotoxicology
Sunday, March 10, 8:15 AM to 12:00 Noon AM08 | MORNING COURSEChairperson(s): Emanuela Corsini and Jamie DeWitt• Introduction to the Course. Jamie DeWitt• Integrated Strategies in Immunotoxicity Risk Assessment. Dori Germolec• Quantitative Risk Assessment in Chemical-Induced Skin Sensitization. Frank Gerberick• Drug-Induced Systemic Hypersensitivity: Mechanistic Understanding and Early Detection.
Jack Uetrecht• Cytokine Production from Mechanistic Understanding to Use in Safety Assessment.
Wimolnut Manheng

Microbiome and Environmental Toxicants: From Study Design andAnalysis to Regulatory Guidance
Sunday, March 10, 1:15 PM to 5:00 PM PM13 | AFTERNOON COURSEChairperson(s): Sarah Blossom and Sangeeta Khare• The Microbiome in Immunotoxicology: Current State-of-the-Science. Sarah Blossom• Non-animal and Animal Models to Test the Effect of Xenobiotics on the Intestinal
Microbiome and Gut Associated Immune Responses during Developmental Stages.
Sangeeta Khare• Microbiome Experimental Design for More Effective Planning and Execution ofMultigenerational Toxicology Studies. Kenneth Drake• An Overview of Current Microbiome Analysis Tools. Folker Meyer• The Emerging Issue of Microbiome Therapeutics: Regulatory Aspects of Microbiome
Perturbation. Paul Carlson

February 20194

Immunotoxicology Specialty Section

ITSS Programs at SOT 2019 (Continued)
Symposia
Immune-Epithelial Cell Crosstalk in Lung Toxicology and Disease
Monday, March 11, 1:45 PM to 4:30 PM
Chairperson(s): Alessandro Venosa and Andrew Gow.
• Introduction. Andrew Gow.
• Alveolar Type II Cells Initiate and Modulate Inflammation in Lung Surfactant. Alessandro Venosa.
• Extracellular Vesicle: An Emerging Mediator of Intracellular Crosstalk in Lung Inflammation and Injury.
Jin Yang.
• To Each Their Own: Molecular Mechanisms of Inter-Individual Variability in the Effects of Inhaled
Toxicant Exposures. Shaun D. McCullough• Mechanisms of Exposure-Based Injury in the Resident Tissues of the Lung. Laura Van Winkle.
• Inflammatory Responses of Resident and Recruited Immune Cells to Inhaled Toxicants. Kymberly
Gowdy.

The Current Application, Limitations, and Recent Advances in Humanized Mouse
Models for Evaluations of Immune Function and Preclinical Immunotoxicology
Studies
Tuesday, March 12, 3:00 PM to 4:30 PM
Chairperson(s): Mark Collinge and Michael Brehm.
• NSG Mice Deficient in Murine MHC Class I and Class II Expression Support Engraftment of Functional
Human T Cells in the Absence of Acute Xenogeneic GVHD following Injection of PBMC. Michael
Brehm.
• Characterization of the Immune System in Humanized Immune System Mice for Use as PreclinicalModels of Drug Safety and Efficacy. Michael Oropallo.
• Recent Advances in the Utilization of Humanized Mouse Models for Toxicology Assessment of Novel
Therapeutics. James Keck.

Workshop
Understanding the Impact on the Immune System of Occupationally Relevant
Exposures to Multiwalled Carbon Nanotubes
Wednesday, March 13, 8:00 AM to 10:45 AM
Chairperson(s): Nigel Walker and Victor Johnson.
• Introduction. Nigel Walker.
• Perspectives from the Field: Occupational Exposures to Carbon Nanotubes in the US. Matthew
Dahm.
• Pulmonary and Systemic Immunotoxicity following Inhalation of Multiwalled Carbon Nanotubes.
Victor Johnson.
• Consequences of Inhalation Pre-exposure to Multiwalled Carbon Nanotubes on Airway Inflammation
and Fibrosis Induced by House Dust Mite Allergen. James Bonner.
• Characterization of Inflammatory Responses and Redistribution of MWCNT following Aerosol
Exposure in B6C3F1/N Mice. Andrij Holian.
• Moderated Panel Discussion. Victor Johnson.
February 20195

Immunotoxicology Specialty Section

Student & Postdoctoral Report
Dear graduate students and postdocs,
By the time this newsletter pops-up on your email you may have already made up your mind of your feelings
towards 2019. Do not despair, we are just a month away from SOT and your year is going to change for the
better!
As for the previous years, ITSS offered several awards for Graduate Students:• Best Presentation by a Student Award• Best Paper of the Year Award• Prakash Nagarkatti Research Excellence in Immunology Award
and Postdocs:••••

Best Presentation by a Postdoctoral Trainee Award
Best Paper of the Year AwardHESI Immunotoxicology Young Investigator Travel Award
Prakash Nagarkatti Research Excellence in Immunology Award.

We are happy to report that graduate students and postdocs
have submitted high quality research for the ITSS awards!
As the 58th Annual Meeting in Baltimore is right around the corner,
we would like to encourage trainees to attend the
Graduate Student and Postdoc Mixer and the 5th Annual
ITSS Networking/Mentoring Event at the Annual Meeting(Hilton Baltimore Key 9, 4:15pm to 5:45pm). This event gives
participants the opportunity to interact with diverse
panelists from academia, industry and government.
The participants are able to connect with these experts to learn about what it is like to hold their positions
and ask advice on career planning. Our tremendous group of mentors made last year‟s event a success,and we are excited to be able to provide another great line up this year.
We also encourage the ITSS trainee members to participate in the ITSS committees. This is a great way to
get involved in leadership activities with other ITSS members and to enhance your professional network.
There are 4 different committees within ITSS: Awards, Program, Education andCommunication/Membership, each chaired by friendly and motivated members of the ITSS executive
committee. Participating in these activities can be rewarding and it is also great opportunity to get to know
the immunotox community.
If you would like to get more involved please contact us avenosa@pennmedicine.upenn.edu or
alexa.murray18@gmail.com.
We look forward to seeing you in
Baltimore!
Alessandro Venosa, Pharm.D., Ph.D.
and Alexa Murray

February 20196

Immunotoxicology Specialty Section

Member Spotlight
Angela Groves, Ph.D.
University of Rochester
Medical Center
When did you begin your career in
immunotoxicology?
I participated in a work study program as an undergraduate at the
University of Montana in the lab of Dr. Elizabeth Putnam and wasfortunate to be able to contribute to some very interesting studies
on asbestosis. I have a memory of learning that when lungmacrophages have trouble phagocytosing asbestos fibers thisprocess is called “frustrated phagocytosis” and the mental pictureof this piqued my curiosity in immune cells. Later upon starting mygraduate program in toxicology at Rutgers University I was excited
to join the lab of Dr. Debra Laskin, who is an expert in macrophage
biology. My work at the University of Rochester continues to focus
on immunological mechanisms and I think that the immune system
will always continue to captivate my interest.

When did you start participating in the ITSS?
I first started attending the ITSS SS receptions at the annual meeting as a graduate student and later
became involved as a postdoc, serving as the postdoc representative for 2 years.

What was your most rewarding experience involving ITSS?
I very much enjoyed working on the newsletter. I thought that compiling all the recent member
accomplishments, committee updates and latest publications was a great way to get an overview on
the current climate of immunotoxicology. That said, my favorite aspect of serving as the postdoc
representative was getting to know and work with the other executive members who were so warm,
enthusiastic and dedicated.

What motivated you to be an active participant in the ITSS and what has
been the largest benefit for you?
I was interested in serving as the postdoc representative because I was seeking out more experiencesthat would help with career development. Having the opportunity to work closely with other experts ina professional setting and to successfully carry out a project that promotes the continued developmentof the field is something that I was very proud to be able to do as an ITSS member. Acquiring thisknow-how was invaluable to me. This experience was also beneficial in helping me to establish a
network of associates that I can utilize for their professional and scientific expertise as I progress
through each stage of my career.

February 20197

Immunotoxicology Specialty Section

Member Spotlight (Continued)
What experiences best prepared you for your position now?
So much of being a scientist is about convincing people to get behind your ideas, which in myacademic position, is accomplished through applying for grants, getting papers published, etc., as we
all know. I was very fortunate as a postdoc that my mentor, Dr. Jacob Finkelstein, allowed me to bevery involved in not only the data generating, but also the writing aspects of his grant application
processes, and also encouraged me to submit my own grant applications. I feel that this was very
good preparation for all the writing that is needed as an academic researcher.

Do you have any advice for someone who is considering becoming more
involved in an SS or SIG?
I would encourage them to sign up! I found the experience to be very worthwhile. The services thesegroups provide are further strengthened through member participation, so your involvement will not
only benefit the SS/SIG, but the opportunities and advice you will get when you connect with others inyour field will be even more rewarding.

What do you perceive to be the next big breakthrough in immunotox?
I think that a breakthrough at the intersection of immunotoxicology and personalized medicine would
be transformative. To be able to identify and use patient-specific biomarkers for diagnostic purposes
and for the targeting of therapeutics in order to prevent or correct immune dysfunction has thepotential to result in more effective patient care.

What do you like the most about working in academia?
I like that academics often have the freedom to commit to an area and research and to be able topublish a body of work in that field. Additionally, the relatively long terms of some grants allow for us
to work on projects that forgo more immediate returns so that outcomes that require longer
commitments can be explored.

How do you maintain work/life balance during the transition to
independency?
Although it is tricky, I have really tried to commit to some of my artistic passions outside of science
because I also want to these to have importance in my life. I love making pottery and find it to be agreat stress reliever. I have loved taking a weekly class at a nearby pottery studio, and I think that thefact that I have to commit to going to pottery after work once a week when I sign up for the class is agreat way for me to not put this passion on the backburner.

What is one fun fact about yourself that you would like to share withothers?
I love anything artsy. I like to draw, paint, make jewelry, sew, knit, crochet and make pottery, among
other artistic things.

February 20198

Immunotoxicology Specialty Section

Member Spotlight
Chidozie Amuzie, DVM, Ph.D., DACVP, DABTScientific Director at Janssen Pharmaceutical
Companies
When did you begin your career in immunotoxicology?
I started in grad school around 2005, as a research assistant at thecenter for integrative toxicology at Michigan State University (MSU).

When did you start participating in the ITSS?
I started participating in 2005 essentially by attending the SOTannual meeting and Itox-focused meetings like one hosted
by NIOSH-Morgantown in the same year.

What motivated you to be a part of ITSS?
My major advisor James Pestka was into ITSS. He did not hang plaques in his office as there were
probably too many, but he had one ITSS best publication plaque from 2003 perhaps. I often stared atthat plaque during our 1:1 meetings and felt that Jim thought a bit highly of ITSS.

What was your most rewarding experience involving ITSS?
Ten years ago, I received one of the trainee awards. I was only awarded third place, but the plaque,$500 (before tax) and some visibility at SOT and MSU felt really great as a young trainee.

How did you make the transition from Post-doc to industry?
My path was nontraditional, as I was lucky to get an industry-funded toxicologic pathology residency.
At the time, my focus was on a scholarly career which was synonymous with universities for somereason. The residency took me to a CRO in Michigan (MPI Research), now Charles River in Mattawan
for one year. I was amazed to find different kinds of scholars there. Dr. Paul Ross, the necropsy
pathologist inspired me with his integrated knowledge of biomedical sciences across species. I
experienced the depth and breadth of studies that supported drug, food and occasionallyenvironmental safety. It was a good perspective on the immediate impact of applied safety science at
a level that wasn‟t very apparent from my academic toxicology training/experience.

How does the future look in the immunotoxicology field?
Future looks exciting, especially in drug safety where I follow closely. There are many examples
across organ systems and disease states, where investigators are attempting to use knowledge of theimmune system in different ways for drug delivery and disease alleviation. Some of these efforts havemade significant impact already as exemplified by the Jim Allison‟s recent Nobel prize for checkpoint
inhibitors. As we go deep into the era of personalized medicine, we will need to continually evolve fromclassic dose-response xenobiotic-driven immunotoxicology to immune safety assessment of
personalized biotherapeutics like CAR-Ts. We will need to learn a lot from other disciplines and allow
computer to help us in knowledge creation and decision making.
February 20199

Immunotoxicology Specialty Section

Member Spotlight (Continued)
What would you do to improve industry-academia interactions?
Increase the number of (unpaid) adjunct Professorships, and industry mentors for students as well as
encourage internships. When I was at MSU some scientists came from Pfizer then in Ann Arbor, Dow
in Midland, MI and occasionally from out of state. We also had opportunity to write papers withindustry scientists and this is how I got acquainted with Glenn Cantor who has supported andmentored me in many ways since then.

What experiences best prepared you for your job?
I have been lucky to have very dedicated and diverse professors, mentors and supervisors acrosscontinents. They allowed me to experience the discipline of structured programs while giving me room
to find things that interested me outside of the structured programs. One of my best elective classes
was an environmental law class where we used the supreme court arguments on landmark toxicologyrelated cases (benzene, ozone, etc). It was an early reminder that the numbers we generate in
toxicology experiments have impact on people and their pockets. So, we need to strive for precisionand rigor in our service to communities as safety professionals. Overall, I owe a debt of gratitude to
my PhD graduate committee of all SOT members (Patti Ganey, Bob Roth, Jack Harkema and Jim
Pestka). They helped me understand that there will be no substitute for rigor in scientific inquiry andthat understanding cytokines is the beginning of wisdom!

What has been the largest benefit, for you, of being an active participant in
an SOT SS like the ITSS?
I participate in a few SS and am currently the president of the Toxicologic and Exploratory Pathology
Specialty Section (TEPSS). SS activities have helped me build the right network to advance myscholarly interest in immunopathology/immunotoxicology and prepared me to use immune safetyassessment as a platform for scholarly engagement.

Do you have any advice for someone who is considering becoming more
involved in an SS or SIG?
Seek opportunities to volunteer and give it your best. It helps SOT and might help you too! I learned a
lot about leadership while serving as student/postdoc rep and I acquired very good mentors too.

How has working in industry settings impacted your personal andscientific growth?
It has led to a greater appreciation for collaboration and team work. Every piece, from everyone isimportant. I have a better appreciation for disciplinary and demographic diversity in problem solving.

What is one fun fact about yourself that you would like to share withothers?
My 7-year old daughter was recently asking me practice questions for US citizenship interview. I failed
a few of those but she felt that my foreign accent, especially improper pronunciation of “r”, should be
disqualifying. Am glad the USCIS officer had lower standards than her.

February 201910

Immunotoxicology Specialty Section

Announcement

Immunotoxicology
Specialty Section
Networking/Mentoring Event
2019 information:
Date: Wednesday, March 13th
Location: Hilton - Baltimore Key 9
Time: 4:15-5:45pm

IMPORTANT INFORMATION
 You do not have to be a ITSS member to participate!
 Look for an ITSS email with the list of mentors in theupcoming weeks!!

NETWORKING

February 201911

Immunotoxicology Specialty SectionReport from JSIT
The 25th annual meeting of the Japanese Society of Immunotoxicology (JSIT) took placeon September 18-19, 2018 at the Tsukuba International Congress Center, a modern
conference center in the heart of Tsukaba, Japan. Tsukuba, in Ibaraki Prefecture, is about
40 miles (65 km) northeast of Tokyo.
The central theme for the JSIT annual meeting was „Deepening insight into interactions
between the immune system and environment.‟ In attendance were over 130 scientists inacademia, government and private sector from Japan, as well as from other countries in
Asia. The ITSS and JSIT have undertaken an international collaborative venture to foster
the exchange of scientists and scientific ideas. Each year, the SOT Global Initiatives Fundand the ITSS support a scientist from Japan to participate in the SOT meeting, and also
supports a scientist from outside of Japan to participate in the JSIT meeting. I had thevery distinct honor of being invited to attend the JSIT, and gave a special lecture during
the conference.

This was a special meeting for the JSIT as it
Keiko Nohara, JSIT President, and Paige Lawrence with a
special guest: Fukkun Sencho
marked their first quarter century. As part oftheir 25th year celebration, there was aspecial banquet and award ceremony at the
Hotel Grand Shinonome. In addition topraising the numerous achievements of JSIT
members and welcoming new members,
several young investigators received awards.
During the reception, there was lively andwarm conversation, and a visit from Fukkun
Sencho, a robot owl who is the mascot of
Tsukuba. Throughout the evening, several
members of the JSIT displayed remarkabletalents that included dancing, theatricalreadings, and musical performances. These
were among the highlights of the reception,
not only because art transcends language,
but because the level of encouragement,
sharing, and fun that these performances added to the evening was entirely special. The
overall atmosphere at the reception radiated happiness and camaraderie. It was afantastic reminder that, no matter how stressful we find our jobs, there is much joy in our
careers and our lives, and it is important to take the time to share, to celebrate, and tolaugh together.

February 201912

Immunotoxicology Specialty SectionReport from JSIT

There was a lot of very interesting research conveyed through the compelling data inposters and oral presentations. Session topics included “Immune modulation
by epigenetic modification of regulatory Tregs,” “Gut microbiota and immune
diseases: A new perspective on immunotoxicology,” as well as a workshop entitled“Development of cancer immunotherapy and safety assessment of immune checkpoint
inhibitors.” Other excellent scientific work that was shared included novel ways tointegrate data on serum levels of acute phase response markers to better distinguishliver cancer and liver injury, and research to better define how exposure to arsenic
contributes to allergic disease.
En route to the conference, I had the opportunity to see a little bit of Tokyo, including
the Asakusa Kannon (Sensoji) Temple. This is the oldest Buddhist temple in Tokyo, anddates back to about 645 BCE. Despite many tourists, the courtyard in front of the Temple
and a nearby shrine radiate harmony and tranquility. The busy Nakamise that spans
between the impressive Kaminarimon Gate and Hozomon Gate is less tranquil because
it is filled with many interesting little shops. But, it conveys a positive energy that isdifficult to describe, but the overall feeling of harmony strangely percolates from thetemple into this busy street.
I am very grateful to Dr. Keiko Nohara for the tremendous efforts she put into
organizing the conference, and for the time she spent helping to coordinate and arrange
my itinerary in Japan. Also, before I departed for the airport, Dr. Tomoki Fukuyama
took me to an ancient Shinto shrine on Mount Tsukuba. This was a relaxing and very
special way to end my trip to Japan, and I am grateful for this little excursion.
Being able to exchange knowledge and ideas with our colleagues in other parts of
the world is one of the most enriching and rewarding experience.
B Paige Lawrence, PhD
Professor and Chair,
Department of Environmental Medicine
Professor,
Department of Microbiology and Immunology
University of Rochester School of Medicine and Dentistry
February 201913

Immunotoxicology Specialty Section

Endowment Fund Update
We wanted to take this opportunity to thank everyone who has contributed to theMitzi and Prakash Nagarkatti Research Excellence in Immunotoxicology
Award Fund. This fund was established to encourage graduate students andpostdoctoral scholars to pursue cutting-edge mechanistic research on
immunomodulation seen in health and disease and share that widely with theresearch community.

The current amount of the endowment is $47,850 and we need to raise$2,150 before January 2020 to make it permanent. Please consider thisimportant fund for your summer or end of the year donations. Keep in mind thatSOT donation matching will not occur again until July 2019.
We thank you in advance for your generosity and look forward to making the
Nagarkatti Endowment a permanent part of the Immunotoxicology Specialty
Section!
Stacey Anderson, PhD
Secretary/Treasurer

Use the online giving system or download the Donation form to make agift to the Mitzi and Prakash Nagarkatti Research Excellence in
Immunotoxicology Award Fund
February 201914

Immunotoxicology Specialty Section

Recent Publications
Compiled by Alessandro Venosa and Alexa Murray. Anytime you have a new fully-publishedor electronically available article to report, please send the citation to Alessandro atavenosa@pennmedicine.upenn.edu.

Alastair Mak, Ryuji Kato, Kyle Weston, Anthony Hayes, and Jack Uetrecht. An Impaired Immune
Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone andTolcapone/Entacapone to Cause IDILI. Toxicological Sciences 161, no. 2(2018): 412–20. Tox Sci Paper of the Year Award
Azoury ME, Filì L, Bechara R, Scornet N, de Chaisemartin L, Weaver RJ, Claude N, Maillere B,
Parronchi P, Joseph D, Pallardy M. Identification of T-cell epitopes from benzylpenicillin conjugated tohuman serum albumin and implication in penicillin allergy. Allergy. 2018 Aug;73(8):1662-1672. doi:
10.1111/all.13418.
Barnett, J.B. 2018 Consequences of Blocking the Choreography of Double Negative Thymocyte
Maturation. In Signaling Mechanisms RegulatingT cell Diversity and Function, in CRC Methods in
Signal Transduction Series, Editors, Jonathan Soboloff and Dietmar J. Kappes. CRC Press, Taylor andFrancisBeamer CA, Kreitinger JM, Cole SL, Shepherd DM. Targeted deletion of the aryl hydrocarbon receptor
in dendritic cells prevents thymic atrophy in response to dioxin. Arch Toxicol. [Epub ahead of print]
Bechara R, Maillere B, Joseph D, Weaver RJ, Pallardy M. Identification and characterization of a naïve
CD8+ T-cell repertoire for benzylpenicillin. Clin Exp Allergy. 2019 Jan 18. doi: 10.1111/cea.13338.
[Epub ahead of print]
Bechara R, Nabhan M, Antonios D, Azouri H, Pallardy M. IL-27 Production and Regulation in Human
Dendritic Cells Treated with the Chemical Sensitizer NiSO4. Chem Res Toxicol. 2018 Nov 27. doi:
10.1021/acs.chemrestox.8b00203. [Epub ahead of print]
Burleson SCM, Freeburn WJ, Burleson FG, Burleson GR, Johnson VJ, and Luebke RW (2018) Host
Resistance Assays. Methods Mol. Biol. 1803: 117-145.
Burleson SCM, Freebern WJ, Burleson FG, Burleson GR, Johnson VJ, and Luebke RW (2018). Host
Resistance Assays. In DeWitt JC et al. (eds.), Immunotoxicity Testing: Methods and Protocols,
Methods in Molecular Biology, vol. 1803, Chapter 9, Pp:117-145.
Burleson, SCM. and Johnson, VJ. (2018) Hypersensitivity Reactions in the Respiratory Tract. In:
McQueen, C. A., Comprehensive Toxicology, 3rd Edition. Elsevier Ltd., Kidlington, United Kingdom.
Chapter 11.27, Pp. 599-622
Castañeda AR, Pinkerton KE, Bein KJ, Magaña-Méndez A, Yang HT, Ashwood P, Vogel CFA. Ambientparticulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17
polarization. Toxicol Lett. 2018 Apr 22;292:85-96.
Castañeda AR, Vogel CFA, Bein KJ, Hughes HK, Smiley-Jewell S, Pinkerton KE. Ambient particulatematter enhances the pulmonary allergic immune response to house dust mite in a BALB/c mousemodel by augmenting Th2- and Th17-immune responses. Physiol Rep. 2018 Sep;6(18):e13827.

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Recent Publications (Continued)
Franko, Jennifer, McCall, Jamie L. and Barnett, John B. 2018 Evaluating Macrophages in
Immunotoxicity Testing. In Immunotoxicity Testing: Methods and Protocols, Eds. Jamie C. DeWitt,
Cheryl E. Rockwell, and Christal C. Bowman, Springer Nature
Huang, G., Xu, J., Cai, D., Chen, S. Y., Nagy, T., & Guo, T. L. (2018). Exacerbation of Type 1 Diabetes
in Perinatally Genistein Exposed Female Non-Obese Diabetic (NOD) Mouse Is Associated With
Alterations of Gut Microbiota and Immune Homeostasis. Editor‟s Highlight Toxi Sci, 165(2), 291-301.
Holaskova, Ida, Meenal Elliott, Kathleen Brundage, Ewa Lukomska, Rosana Schafer and John B
Barnett. 2019. Long-term immunotoxic effects of oral prenatal and neonatal atrazine exposure. Toxicol
Sciences. (ahead of print) doi: 10.1093/toxsci/kfz005
Impinen A, Longnecker MP, Nygaard UC, London SJ, Ferguson KK, Haug LS, Granum B. Maternal
levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma
related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort. Environ Int. 2019
Jan 23;124:462-472.
Ishihara Y, Ikeda-Ishihara N, Koriyama C, Kakiuchi N, Tanaka M, Vogel CFA, Kawamoto T, Tsuji M.
Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay withpartial peptides of human serum albumin. J Toxicol Sci. 2018;43(1):25-31. doi: 10.2131/jts.43.25.
PubMed PMID: 29415949.
Johnson VJ, Germolec DR, Luebke RW, and Luster MI. (2018). Immunotoxicity Studies. In: McQueen
C (Ed.) Comprehensive Toxicology, 3rd Edition. Elsevier Ltd., Kidlington, United Kingdom. Chapter
9.17, Pp. 255-270.
Laskin DL, Malaviya R, Laskin JD. Role of Macrophages in Acute Lung Injury and Chronic Fibrosis
Induced by Pulmonary Toxicants. J Toxicol Sci. 2018. (ahead of print) doi: 10.1093/toxsci/kfy309
Lee H, Zhang D, Laskin DL, Jin Y. Functional Evidence of Pulmonary Extracellular Vesicles in
Infectious and Noninfectious Lung Inflammation. J Immunol. 2018; 201(5):1500-1509. doi:
10.4049/jimmunol.1800264.
Li Q, Yang Z, Zhang P, Zhao Y, Yu X, Xue P, Shao Y, Li Q, Jia X, Zhang Q, Cheng L, He M, Zhou Z,
Zhang Y. Mercury impact on hematopoietic stem cells is regulated by IFNγ-dependent bone marrowresident macrophages in mice. Toxicol Lett. 2018 Oct 1;295:54-63.
Li Q, Yang Z, Zhao Y, Jia X, Zhou Z, Zhang Y. Phenotypic and Functional Evaluation of Hematopoietic
Stem and Progenitor Cells in Toxicology of Heavy Metals. Curr Protoc Toxicol. 2018 Feb 21;75:22.7.122.7.14.
Nureki, S. I., Tomer, Y., Venosa, A., Katzen, J., Russo, S. J., Jamil, S., Barrett, M., Nguyen, V., Kopp,
M., Mulugeta, S., Beers, M. F. (2018). Expression of mutant Sftpc in murine alveolar epithelia drives
spontaneous lung fibrosis. J Clin Invest. 2018;128(9):4008-4024.
Nygaard UC, Vege Å, Rognum T, Grob K, Cartier C, Cravedi JP, Alexander J. Toxic effects of mineraloil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver. Food Chem Toxicol 2018;
123:431-42.

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Recent Publications (Continued)
Raffalli C, Clouet E, Kuresepi S, Damiens MH, Lepoittevin JP, Pallardy M, Ferret PJ, Giménez-Arnau E,
Kerdine-Römer S. Editor's Highlight: Fragrance Allergens Linalool and Limonene Allylic Hydroperoxides
in Skin Allergy: Mechanisms of Action Focusing on Transcription Factor Nrf2. Toxicol Sci. 2018 Jan
1;161(1):139-148. doi: 10.1093/toxsci/kfx207
Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown ricegrains and of the allergenicity of products containing rice bran. Food Chem. 2019 Mar 15;276:761-767.
Schafer, Rosana, Ted Ognibene, Michael Malfatti, Kenneth Turteltaub, and John B. Barnett. 2018
Comparative Pharmacokinetics of High and Low Doses of the Herbicide Propanil in Mice. Chem
Research Toxicology, doi:10.1021/acs.chemrestox.8b00151
Shim, J.K., Kennedy, R. H., Weatherly, L.M., Abovian, A.V., Hashmi, H.N., Rajaei, A., and Gosse, J.A.
Searching for Tryptase in the RBL-2H3 Mast Cell Model: Preparation for Comparative Mast Cell
Toxicology Studies with Zebrafish; in press at Journal of Applied Toxicology, 2018.
Sunil VR, Vayas KN, Cervelli JA, Ebramova EV, Gow AJ, Goedken M, Malaviya R, Laskin JD, Laskin
DL. Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by
Nitrogen Mustard. Toxicol Sci. 2018;166(1):108-122. doi: 10.1093/toxsci/kfy188.
Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM,
Laskin DL, Laskin JD. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5
reductase. Toxicol Appl Pharmacol. 2018; 359:102-107. doi: 10.1016/j.taap.2018.09.011.

Tsuji M, Koriyama C, Ishihara Y, Vogel CFA, Kawamoto T. Association between bisphenol A diglycidyl
ether-specific IgG in serum and food sensitization in young children. Eur J Med Res. 2018 Dec
26;23(1):61.
van Vliet E, Kühnl J, Goebel C, Martinozzi-Teissier S, Alépée N, Ashikaga T, Blömeke B, Del Bufalo A,
Cluzel M, Corsini E, Delrue N, Desprez B, Gellatly N, Giese C, Gribaldo L, Hoffmann S, Klaric M,
Maillere B, Naisbitt D, Pallardy M, Vocanson M, Petersohn D. State-of-the-art and new options toassess T cell activation by skin sensitizers: Cosmetics Europe Workshop. ALTEX. 2018;35(2):179-192.
doi: 10.14573/altex.1709011. Epub 2017 Oct 2.
Nureki SI*, Tomer Y*, Venosa A*, Katzen J, Russo SJ, Jamil S, Barrett M, Nguyen V, Kopp M, Mulugeta
S, Beers MF. Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis.J
Clin Invest. 2018; 128(9):4008-4024. doi: 10.1172/JCI99287.
Wang Y, Revollo J, McKinzie P, Pearce MG, Dad A, Yucesoy B, Rosenfeldt H, Heflich RH, Dobrovolsky
VN: Establishing a novel Pig-a gene mutation assay in L5178YTk+/- mouse lymphoma cells. Environ
Mol Mutagen, 59(1):4-17, 2018.

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Recent Publications (Continued)
Weatherly, L.M., Nelson, A.J., Shim, J., Riitano, A.M., Gerson, E.D., Hart, A.J., de Juan-Sanz, J., Ryan,
T.A., Sher, R., Hess, S.T. and Gosse, J.A. Antimicrobial agent triclosan disrupts mitochondrial structure,
revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation. 2018,
Toxicol Appl Pharmacol; 349:39-54. doi: 10.1016/j.taap.2018.04.005.
Yucesoy B & Gallucci R, Systems Biology in Immunotoxicology. In: McQueen, C. A., Comprehensive
Toxicology, Third Edition. Vol. 11, pp. 559–581. Oxford: Elsevier Ltd, 2018.
Zhang J, Fulgar CC, Mar T, Young DE, Zhang Q, Bein KJ, Cui L, Castañeda A, Vogel CFA, Sun X, Li
W, Smiley-Jewell S, Zhang Z, Pinkerton KE. TH17-Induced Neutrophils Enhance the Pulmonary
Allergic Response Following BALB/c Exposure to House Dust Mite Allergen and Fine Particulate Matter
From California and China. Toxicol Sci. 2018 Aug 1;164(2):627-643.
Zhao Y, Li Q, Yang Z, Shao Y, Xue P, Qu W, Jia X, Cheng L, He M, He R, Zhou Z, Zhang Y. Cadmium
Activates Noncanonical Wnt Signaling to Impair Hematopoietic Stem Cell Function in Mice. Toxicol Sci.
2018 Sep 1;165(1):254-266.

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Immunotoxicology Specialty Section

Achievements and Awards
Cheryl Rockwell, PhD
Associate Professor
Department of Pharmacology & Toxicology
Michigan State University
2019 Early Career Award ASPET
Toxicology Division

Chris Vogel, PhD
Research Professor
Department of Environmental Toxicology
University of California Davis
2018 Muir Institute Fellow

Alessandro Venosa, PharmD, PhD
Postdoctoral Researcher
University of Pennsylvania School of
Medicine
2019 Usha Awards APS, Respiratory
SectionFebruary 201919

Immunotoxicology Specialty Section