Link to Research Activity

CURRICULUM VITAE
Name:

Keiji Wakabayashi

Present Position:

Professor
Food and Environment Research Center
Graduate Division of Nutritional and Environmental Sciences
University of Shizuoka

Address:

52-1 Yada, Shizuoka, 422-8526, Japan(Phone) +81-54-264-5784(Fax) +81-54-264-5904(E-mail) kwakabayashi<at>u-shizuoka-ken.ac.jp

Education and Employment:
1971
1977

Shizuoka College of Pharmacy, B. Pharm. Sci.
Shizuoka College of Pharmacy, Ph. D.

1979-1985
1985-1994

Research Staff, National Cancer Center Research InstituteSection Head, Carcinogenesis Division, National Cancer CenterResearch Institute1994-1997
1997-2002

Chief, Biochemistry Division, National Cancer Center Research InstituteChief, Cancer Prevention Division, National Cancer Center ResearchInstitute
Deputy Director, National Cancer Center Research Institute2002-2007
200220072011-2014
2014-

Project Leader, Cancer Prevention Basic Research Project, NationalCancer Center Research Institute
Director, National Cancer Center Research Institute
Professor, Institute for Environmental Sciences, University of Shizuoka
Professor, Graduate Division of Nutritional and Environmental Sciences,
University of Shizuoka

Awards:Japanese Environmental Mutagen Society Achievement Award, 1985
Incitement Award of the Japanese Cancer Association, 1986
Prize of the Princess Takamatsu Cancer Research Fund, 2005
Japanese Environmental Mutagen Society Award, 2008
Prince Hitachi Prize for Comparative Oncology, 2010

Editorial Boards:
Cancer Epidemiology Biomarkers and Prevention
International Journal of CancerSocieties:
Japanese Association for Cancer Prevention
Japanese Biochemical Society
Japanese Cancer Association
Japanese Environmental Mutagen Society
American Association for Cancer ResearchSpecialty and Present Interests:
Food-derived mutagens and carcinogens, and their modification of DNA.
Chemoprevention by dietary factors and medicines.
List of major publications:
1) Wakabayashi, K., Ochiai, M., Saito, H., Tsuda, M., Suwa, Y., Nagao, M. andSugimura, T. Presence of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid,a precursor of a mutagenic nitroso compound, in soy sauce. Proc. Natl. Acad. Sci.
USA, 80: 2912-2916 (1983).
2) Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. Food-derived mutagens
and carcinogens. Cancer Res. (Suppl.), 52: 2092s-2098s (1992).
3) Nukaya, H., Yamashita, J., Tsuji, K., Terao, Y., Ohe, T., Sawanishi, H., Katsuhara,T., Kiyokawa, K., Tezuka, M., Oguri, A., Sugimura, T. and Wakabayashi, K. Isolationand chemical-structural determination of a novel aromatic amine mutagen in waterfrom the Nishitakase river in Kyoto. Chem. Res. Toxicol., 10: 1061-1066 (1997).
4) Watanabe, M., Kono, T., Matsushima-Hibiya, Y., Kanazawa, T., Nishisaka, N.,
Kishimoto, T., Koyama, K., Sugimura, T. and Wakabayashi, K. Molecular cloning ofan apoptosis-inducing protein, pierisin, from cabbage butterfly: Possible involvementof ADP-ribosylation in its activity. Proc. Natl. Acad. Sci. U.S.A., 96: 10608-10613(1999).
5) Watanabe, K., Kawamori, T., Nakatsugi, S., Ohta, T., Ohuchida, S., Yamamoto, H.,
Maruyama, T., Kondo, K., Ushikubi, F., Narumiya, S., Sugimura, T. andWakabayashi, K. Role of the prostaglandin E receptor subtype EP1 in colon

carcinogenesis. Cancer Res., 59: 5093-5096 (1999).
6) Niho, N., Takahashi, M., Kitamura, T., Shoji, Y., Itoh, M., Noda, T., Sugimura, T. andWakabayashi, K. Concomitant suppression of hyperlipidemia and intestinal polypformation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.
Cancer Res., 63: 6090-6095 (2003).
7) Nakano, T., Matsushima-Hibiya, Y., Yamamoto, M., Enomoto, S., Matsumoto, Y.,
Totsuka, Y., Watanabe, M., Sugimura, T. and Wakabayashi, K. Purification andmolecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam
Meretrix lamarckii. Proc. Natl. Acad. Sci. USA, 103: 13652-13657 (2006).
8) Totsuka, Y., Higuchi, T., Imai, T., Nishikawa, A., Nohmi, T., Kato, T., Masuda, S.,
Kinae, N., Hiyoshi, K., Ogo, S., Kawanishi, M., Yagi, T., Ichinose, T., Fukumori, N.,Watanabe, M., Sugimura, T. and Wakabayashi, K. Genotoxicity ofnano/microparticles in in vitro micronuclei, in vivo comet and mutation assay
systems. Part. Fibre. Toxicol., 6: 23 (2009).
9) Mutoh, M., Teraoka, N., Takasu, S., Takahashi, M., Onuma, K.,Yamamoto, M.,
Kubota, N., Iseki, T., Kadowaki, T., Sugimura, T., Wakabayashi, K. Loss ofadiponectin promotes intestinal carcinogenesis in Min and wild-type mice.
Gastroenterology, 140:2000-2008 (2011).
10) Ishikawa, H., Mutoh, M., Suzuki, S., Tokudome, S., Saida, Y., Abe, T.,
Okamura, S., Tajika, M., Joh, T., Tanaka, S., Kudo, S., Matsuda, T., Iimuro, M.,
Yukawa, T., Takayama, T., Sato, Y., Lee, K., Kitamura, S., Mizuno, M., Sano,Y., Gondo, N., Sugimoto, K., Kusunoki, M., Goto, C., Matsuura, N., Sakai, T.,
Wakabayashi, K. The preventive effects of low-dose enteric-coated aspirintablets on the development of colorectal tumors in Asian patients(Randomized Trial). Gut, 63:1755-1759 (2014).