Program
September 6 (Monday)
9:00 ～ 9:10

Opening Remark

The 28th Annual Meeting of the Japanese Society of Immunotoxicology
President: Reiko Teshima
The 78th Meeting of Allergy and Immunotoxicology study group of Japan Society for Occupational
HealthCoordinator: Takahiko Yoshida

9:10 ～ 11:50 Students and Young Scientists Session＜Y-01 ～ Y-08＞

Chairperson: Yasuo Yoshioika (Research Institute for Microbial Diseases, Osaka
University),
Shigeki Aoki (Graduate School of Pharmaceutical Sciences, Chiba
University)
Y-01 Identification of carbon nanotube receptors〇Sin-Ichiro Yamaguchi1, Masanobu Morita2, Fumiya Ito3,4, Qilin Xie1, Shinya
Toyokuni3,4, Masafumi Nakayama1,4
1Ritsumeikan University, 2Tohoku University Graduate School of Medicine,
3Nagoya University Graduate School of Medicine, 4CREST, JST
Y-02 Spatiotemporal features of health effects of crude PM in Japan and key
components of PM contributing to health effects〇Zaoshi Wang1, Akiko Honda1,2, Tomoaki Okuda3, Shuichi Hasegawa4, Takayuki
Kameda5, Susumu Tohno5, Masahiko Hayashi6, Chiharu Nishita-Hara6, KeiichiroHara6, Kozo Inoue7, Kayo Ueda1,2, Hirohisa Takano1,21Graduate School of Engineering, Kyoto University, 2Graduate School of Global

Environmental Studies, Kyoto University, 3Faculty of Science and Technology,Keio University, 4Center for Environmental Science in Saitama, 5Graduate Schoolof Energy Science, Kyoto University, 6 Fukuoka Institute of Atmospheric
Environment and Health, Fukuoka University, 7TOKYO DYLEC CORP.
Y-03 Impact of ozone gas exposure on percutaneous oxygen saturation and immune
function in a mouse model of acute lung injury〇Chiharu Oohira1, Kengo Tomita2, Chiharu Hayakawa1, Takashi Kurihara2,Tomoki Fukuyama1
1Laboratory of Veterinary Pharmacology, Veterinary Medicine, Azabu University,
2Center for Environmental, Institute of Technology, SHIMIZU CORPORARION

Y-04 Participation of CD44 in Hepatic Fibrosis of Non-alcoholic Steatohepatitis in Rats
〇Kinuko Uno1, Noriko Kemuriyama2, Katsuhiro Miyajima2, Dai Nakae2
1Department of Food and Nutritional Science, Faculty of Agriculture, Graduate
School of Tokyo University of Agriculture, 2Department of Nutritional Science andFood Safety, Faculty of Applied Biosciences, Undergraduate School of Tokyo
University of Agriculture
Y-05 Increase (not decrease) of regulatory T cells associated with fetal loss caused byskewed Th1/Th2 balance toward Th1 side in abortion-prone mouse model〇Miho Sakakibara1, Yosuke Maeda1, Ryo Kamata1 Kazuichi Nakamura1
1School of Veterinary Medicine, Kitasato University
Y-06 Molecular mechanisms of type I interferonopathy in a novel COPA syndromemodel mouse〇Takashi Kato1, Takashi Orimo1, Yuri Fukuda-Ohta1, Naoko WakakiNishiyama1, Chihiro Nakai1, Izumi Sasaki1, Kohei Murakami2, Hiroaki Hemmi2,Yoshitaka Honda3,4,5, Kazushi Izawa5, Yoshiro Otsuki6, Tadashi Matsubayashi7,Ryuta Nishikomori8, Tsuneyasu Kaisho1
1Department of Immunology, Institute of Advanced Medicine, Wakayama Medical
University 2Laboratory of Immunology, Faculty of Veterinary Medicine, Okayama
University of Science, 3Institute for the Advanced Study of Human Biology(ASHBi), Kyoto University,4Department of Immunology, Kyoto University
Graduate School of Medicine, 5Department of Pediatrics, Kyoto University
Graduate School of Medicine, 6Department of Pathology, Seirei Hamamatsu
General Hospital, 7Department of Pediatrics, Seirei Hamamatsu General
Hospital, 8Department of Pediatrics and Child Health, Kurume University Schoolof Medicine
Y-07 Establishment of antisense screening method for innate immune activation via
TLR9〇Misato Tanaka1, Shogo Matsumura1, Kiyoshi Kushima1, Ko Omura1
1Drug Safety Research Laboratories, Astellas Pharma Inc.
Y-08 Analysis of the inhibitory mechanism of vialinin A (VA) on TNF-α production inRBL-2H3 cells〇Shota Yokota1, Jun-ichi Onose1, Kouichi Sugatani1, Naoki Abe1
1Graduate School of Applied Bioscience, Tokyo University of Agriculture

13:00 ～ 13:50 Oral Presentation ＜O-01 ～ O-03＞
Chairperson:Yasumitsu Nishimura (Department of Hygiene, Kawasaki Medical School)O-01 An endoplasmic reticulum stress sensor IRE1α is involved in cholera toxininduced interleukin-1β production from tissue resident macrophages〇Izumi Sasaki1, Yuri Fukuda-Ohta1, Naoko Wakaki-Nishiyama1, Chihiro Nakai1,Shuhei Morita2, Daisuke Okuzaki3, Mika Kaku1, Kanta Sawase1, Takashi Kato1,Takashi Orimo1, Koichi Furukawa4, Tsuneyasu Kaisho1
1Department of Immunology, Institute of Advanced Medicine, Wakayama Medical
University, 2First Department of Medicine, Wakayama Medical University,
3Genome Information Research Center, Research Institute for Microbial Diseases,
Osaka University, 4Department of Lifelong Sports and Health Sciences, Chubu
University College of Life and Health Sciences
O-02 Mechanism of aggravation in the intestinal immune system due to zinc deficiency
and the effects of IL-4 administration or zinc supplementation〇Takamasa Kido1, Machi Suka1, Hiroyuki Yanagisawa1
1The Jikei University School of Medicine
O-03 Induction of IL-1α releases from murine keratinocytes by 2-hydroxyethyl
methacrylate and its inhibition by N-acetyl cysteine〇Toshinobu Kuroishi1, Takahiro Kaji1, Kanan Bando1, 2, Masatoshi Takahashi3,Shunji Sugawara1
1Division of Oral Immunology, 2Division of Orthodontics and Dentofacial
Orthopedics, 3Division of Dental Biomaterials, Tohoku University Graduate
School of Dentistry

14:00 ～ 14:50

Education Lecture 1＜EL-01＞Chairperson:Yoshiro Saito (National Institute of Health Sciences)
EL-01 The significance of allergy and innate lymphocytes (ICL2) from the evolutionary
perspective〇Kenji Matsumoto1
1National Research Institute for Child Health and Development

15:00 ～ 17:00 Symposium ＜S-01 ～ S-03＞“The development status of various vaccine and their safety evaluation”
Chairperson:Etsushi Kuroda (Department of Immunology, Hyogo College of Medicine),
Izumi Sasaki (Institute of Advanced Medicine, Wakayama MedicalUniversity)
S-01 MicroRNAs associated with adverse reactions of vaccine〇Hiroyuki Oshiumi1, Momoka Nakashima1, Yusuke Miyashita1
1Department of Immunology, Faculty of Life Sciences, Kumamoto University

S-02

Safety assessment of nasal vaccine〇Yoshikazu Yuki1,2
1HanaVax Inc., 2Institute of Medical Science, University of Tokyo

S-03 Screening for a safe and effective novel vaccine adjuvant using genomics
technology〇Eita Sasaki1
1Depertment of Safety Research on Blood and Biological Products, National
Institute ofInfectious Diseases

17:10 ～ 18:00

Special Lecture 1＜SL-01＞Chairperson: Hiroaki Hemmi (Veterinary Medicine, Okayama University of Sciences)SL-01 Dendritic cell- based new immunotherapy〇Shin-ichiro Fujii1,2
1Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences
2RIKEN Program for Drug Discovery and Medical Technology Platforms

18:10 ～ 18:25

Special Message

From Dr. Mitchell. D. Cohen (SOT ITSS)

September 7 (Tuesday)
8:40 ～ 9:40

Oral Presentation ＜O-04 ～ O-07＞

Chairperson: Eiko Koike (National Institute for Environmental Studies),
Ryosuke Nakamura (National Institute of Health Sciences)
O-04

Construction of carbamazepine-induced cutaneous disorder model using HLAA*31:01 knock-in mice〇Maho Ichikawa1, Akira Kazaoka1, Naomoto Harada2, Shigeki Aoki1, Kosei Ito1
1Graduate School of Pharmaceutical Sciences, Chiba University, 2 TAIHOPHARMACEUTICAL CO., LTD.

O-05 Association of HLA-DRB1*04:05 allele with drug-induced interstitial lung diseasein Japanese population〇Yoshiro Saito1, Takuya Imatoh1, Masao Ota2, Atsuhito Ushiki2, Masayuki

Hanaoka2
1National Institute of Health Sciences, 2Shinshu University, School of Medicine
O-06

Effects of benzotriazole UV stabilizers on induction of splenic regulatory T cells
through activation of aryl hydrocarbon receptor〇Atsuhito Kubota1, Masaru Terasaki1, Ryuta Muromoto2, Hideshige Takada3,Hiroyuki Kojima1
1Pharmaceutical Sciences, Health Sciences University of Hokkaido, 2Graduate
School of Pharmaceutical Sciences, Hokkaido University 3Faculty of Agriculture,
Tokyo University of Agriculture and Technology

O-07 Benzo[a]pyrene enhances IL-17 response via AhR-mediated Regnase-1
suppression〇Ryuta Muromoto1, Kota Nariya1, Yuka Saino1, Tadashi Matsuda1
1Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido
University

9:50 ～ 10:40

Education Lecture 2＜EL-02＞Chairperson: Reiko Teshima (Veterinary Medicine, Okayama University of Sciences)
EL-02 About the new corona vaccine〇Yasuhiro Yoshikawa1
1Faculty of Veterinary Medicine, Okayama University of Sciences

10:45 ～ 11:40

Awardee Presentation ＜AL-01, AL-02＞

Chairperson: Hiroyuki Kojima (Health Science University of Hokkaido)

JSIT Award Lecture
AL-01 Immunotoxic effects and mechanisms of dioxin〇Keiko Nohara1
1National Institute for Environmental Studies

JSIT Young Investigator Award Lecture
AL-02 Immunotoxicity depending on myeloid-derived suppressor cells in tumor-bearer〇Masashi Tachibana1, 2
1Graduate School of Pharmaceutical Sciences, Osaka University2MEIC., Osaka University

12:40 ～ 13:30

Special Lecture 2＜SL-02＞

Chairperson: Chiyomi Kubo (CHUGAI PHARMACEUTICAL CO., LTD.)
SL-02 Immunogenicity-related toxicity〇Dr. Jeanine Bussiere1
1Scientic Executive Director of Toxicology, Amgen Inc.

13:30 ～ 15:25 Workshop ＜WS-01 ～ WS-03＞“Toward the development and quidance of in vitro immunotoxicity testmethod”
Chairperson: Seiji Kushima (Astellas Pharma Inc)
Tetsuya Sakairi (Mitsubishi Tanabe Pharma Corporation)
WS-01 The current status of Muli-ImmunoToxicity Assay (MITA)〇Setsuya Aiba1,2, Yutaka Kimura1,3, Takao Ashikaga4, Hajime Kojima4
1Deptartment of Dermatology, Tohoku University School of Medicine, 2Matsuda
Hospital, Dermatology Clinic, 3Kimura Ophthalmology Clinic, 4 National
Institute ofHealth Sciences
WS-02 Development of an alternative test method (ADRA) for skin sensitization andadoption into OECD test guideline〇Masaharu Fujita1, Yusuke Yamamoto1, Toshihiko Kasahara1
1FUJIFILM Corporation, Safety Evaluation Center
WS-03 Skin sensitization OECD guideline based on IATA Defined Approach〇Takao Ashikaga1
1National Institute of Health Sciences

15:30

Closing Remark【Poster Presentation by Web <P-01 ～ P-15, Y-01 ～ Y-08> September 3rd to 7th】
(For the 9 presentations of the young session, posters will be posted as well as theoral presentation)
P-01 In vitro effects of D4-siloxane on bone marrow–derived dendritic cells (BMDCs)
Risako Tajiki1, Hitoshi Tajima1, Yuko Watanabe1, Takashi Kakimoto2, Takashi
Kurihara2, Hiroaki Aoyama1〇Tadashi Kosaka11Toxicoligy Division, Institute of Environmental Toxicology, 2Institute ofTechnology, SHIMIZU CORPORARION
P-02 Oral exposure to bisphenol S altered neurobehaviors and related gene expressions
in allergic asthmatic mice〇Tin-Tin Win-Shwe1, Rie Yanagisawa1, Eiko Koike1
1Health and Environmental Risk Division, National Institute for Environmental
Studies
P-03

Effects of oral exposure to bisphenol S on immune cells in allergic asthmatic mice
〇Eiko Koike1, Rie Yanagisawa1, Tin-Tin Win-Shwe1
1Health and Environmental Risk Division, National Institute for Environmental
StudiesP-04 Effects of oral exposure to bisphenol S on allergic pulmonary inflammation inmice〇Rie Yanagisawa1, Eiko Koike1, Tin-Tin Win-Shwe1
1Health and Environmental Risk Division, National Institute for Environmental
StudiesP-05

Induction of THP-1 cells activation by silicon dioxide nanomaterials〇Takao Ashikaga1, Asuka Nishida2, Akiko Ohno1, Kazutomo Iijima2
1National Institute of Health Sciences, 2Yokohama National University

P-06

Silica exposure to human PBMC altered the mRNA expression and the cytokine
production.
〇Suni Lee1, Yasumitsu Nishimura1, Takemi Otsuki2
1Department of Hygiene, Kawasaki Medical School, 2Shinjo Village National
Health Insurance Clinic

P-07

Relationship between immunological characteristics of peripheral blood andefficacy in the treatment of Nivolumab in patients with malignant mesothelioma.
〇Yasumitsu Nishimura1, Suni Lee1, Naoko Takei1, Tatsuo Ito1, Nobukazu
Fujimoto2, Toshiyuki Kozuki3, Takemi Otsuki1,41Deptartment of Hygiene, Kawasaki Medical School, 2Deptment of Medical
Oncology, Okayama Rosai Hospital, 3Deptartment of Thoracic Oncology andMedicine, Shikoku Cancer Center, 4Shinjo-son National Health Insurance Clinic

P-08 Involvement of Th2 cytokines, eotaxin, and periostin in the development ofasthma inarsenic-polluted areas in Bangladesh〇Seiichiro Himeno1, 2, Daigo Sumi2, Keiko Nohara3, Khaled Hossain4
1School of Pharmacy, Showa University, 2Faculty of Pharmaceutical Sciences,
Tokushima Bunri University, 3NIES, 4Rajshahi UniversityP-09 Skimune®, an in vitro human skin explant assay to predict adverse immune
reactions associated with Low Molecular Weight Drugs and Biologics〇AM Dickinson1 and S Ahmed1.
1Alcyomics Ltd, Newcastle upon Tyne, United Kingdom
P-10 Development of an in vitro model of drug-induced toxic epidermal necrosis.
〇A Dickinson1, SS Ahmed1, DF Carr2, A Olsson-Brown2, M Pirmohamed2.
1Alcyomics Ltd, Newcastle upon Tyne, United Kingdom, 2University of Liverpool,Liverpool, United Kingdom
P-11 Fcγ receptor-dependent internalization and off-target cytotoxicity of antibodydrug conjugate aggregates〇Michihiko Aoyama1, Minoru Tada1, Akiko Ishii-Watabe1
1Natinal Institute of Health Sciences
P-12 Mitochondrial permeability transition as a trigger of immune-mediated druginduced liver injury in obese type 2 diabetes〇Kazuma Hamada, Takashi Mizuma
Biopharmaceutics and Molecular Toxicology Unit, Faculty of PharmaceuticalSciences, Teikyo Heisei University
P-13 Regulatory considerations on evaluation and risk mitigating strategies forimmunogenicity of therapeutic protein products〇Akiko Ishii-Watabe1, Hiroko Shibata1, Kazuko Nishimura1, Yoshiro Saito2
1Division of Biological Chemistry and Biologicals, 2Division of Medicinal Safety
Science, National Institute of Health Sciences
P-14 Significant association of HLA-A*11:01 with sulfa drug-related severe cutaneousadverse reactions in Japanese〇Ryosuke Nakamura1, Takeshi Ozeki2, Noriaki Hirayama3, Akihiro Sekine4,
Yoshiko Mizukawa5, Tetsuo Shiohara5, Hideaki Watanabe6, Hirohiko Sueki6,Kohei Ogawa7, Hideo Asada7, Eri Tsukagoshi1, Kayoko Matsunaga8, Hiroyuki
Niihara9, Yukie Yamaguchi10, Michiko Aihara10, Taisei Mushiroda2, Yoshiro
Saito1, Eishin Morita9
1National Institute of Health Sciences, 2RIKEN, 3Tokai University, 4Chiba
University, 5Kyorin University, 6Showa University, 7Nara Medical University,
8Fujita Health University, 9Shimane University, 10Yokohama City University
P-15 Role of lysosomes as an intracellular degradation system for cytotoxicity caused bytraffic-related air pollution in bronchial epithelial cells〇Akira Onodera1, Eiko Fukutomi1, Takuya Shimomura1, Hirohisa Ochi1, Ryuto
Sunada1, Yuichi Kawai1
1Faculty of Pharmaceutical Sciences, Kobe Gakuin University