第 31 回日本免疫毒性学会学術年会プログラム
第 1 日目

9 月 19 日（木）平成記念会館メイン会場

9:00 ～ 9:10

開会式

第 31 回日本免疫毒性学会学術年会
9:10 ～ 10:30

年会長

黒田悦史

学生・若手セッション＜ Y-05 ～ Y-12 ＞

座長：青木重樹（千葉大学大学院薬学研究院）、佐々木泉（和歌山県立医科大学先端医学研究所）
Y-05

カーボンブラック粒子による肺胞マクロファージでの毒性発現機構の解析○石原萌宏、古川敦、長田夕佳、鈴木亮
金沢大院・医薬保Y-06

The novel evaluation approach for the immunotoxicity of environmental particulatematters using a newly developed macrophage line
〇Hinata Inoue1,2, Takumi Adachi1, Etsushi Kuroda1
1

Department of Immunology, Hyogo Medical University, 2physician-scientist training
program, Hyogo Medical University
Y-07

Antagonistic activity of combined exposure to mycotoxins Nivalenol andDeoxynivalenol on the inflammatory cytokine production in dendritic cells〇Reo Matsuzaka1, Kazutoshi Sugita2, Shiro Miyake3, Tomoki Fukuyama1
1

Pharmacology lab, Vet Med, Azabu Univ., 2Public Health lab, Azabu Univ., 3Food andHygiene lab, Azabu Univ.
Y-08

Co-culture of corneal epithelial cells and neutrophil-like cells induces synergistic
production of inflammatory cytokines and chemokines〇Zirui Zeng1, Duo Wang2, Chieri Murayama3, Junnosuke Morita3, Tomoaki Okuda4,
Tatsuya Mimura5, Yasuhiro Yoshida3
1-3

Univ. Occ. Env. Hlth., Dept. of 11st. int. med., 2radi. Manage., 3imm. and para., 4Dept. ofApplied Chem., Fac. of Sci. and Tech., Keio Univ., 5Dept. of opht. Teikyo Univ.
Y-09

MyD88-TRAF6シグナル伝達経路とAhRのクロストーク解析○箱田涼1、村瀬渉1、安田彩夏1、窪田篤人2、進藤つぐみ2、土田史郎2、小島弘幸1,2、
中川宏治1,2
1

北医療大院、薬、2北医療大、薬

13

Y-10

Ⅰ型IFNは鼻腔内投与型アデノウイルスベクターのワクチン効果を減弱させる○仲谷隼1、立花雅史1,2、大西里佳1、清水かほり1、櫻井文教1、水口裕之1,3,4,5,6
1

Y-11

阪大院薬、2立命大生命、3医薬健栄研、4阪大MEIセ、5阪大先導、6阪大CiDER

DNA鎖切断に起因するインターフェロン応答における核酸センサー cGAS, IFI16の役割の探索○寺越菜央1、山北啓吾1、安井学2、本間正充2、杉山圭一2、菅澤薫3、浦聖恵1、佐々彰1
1

千葉大学大学院融合理工学府、2国立医薬品食品衛生研究所ゲノム安全科学部、3神戸大学
バイオシグナル総合研究センター
Y-12

有機フッ素化合物（PFAS によるマウス免疫細胞のサイトカインおよび抗体産生能に及ぼす影響○村瀬渉1、窪田篤人2、室本竜太3、久保田彰4、吉成浩一5、アイツバマイゆふ6、小島弘幸1,2
1

北医 療大 院、薬、2北医療大、薬、3北 大 院、薬、4帯畜大、獣、5静岡県大、薬、6北大、
環境健康セ
＜休憩＞
10:40 ～ 11:10 一般演題１＜ O-01 ～ O-02 ＞
座長：窪田篤人（北海道医療大学薬学部）
O-01

アデノウイルスベクターを用いた経肺ワクチンによる抗体応答と肺での免疫毒性の連関解析○平井敏郎1,2,3,4、上田晃樹2,3、柿原真子2,3、高山和雄5、吉岡靖雄1,2,3,4,6,7,8
1

阪大、先導、2阪大、微研、3阪大院、薬、4阪大、CAMaD、5京大、CiRA、6微研財団、
7
阪大、MEIセ、8阪大、CiDER

O-02

Imaging inflammatory response of mouse alveolar macrophage induced byenvironmental particulates using Live FluoroSpot〇Zhuohao Yang1, Takumi Adachi2, Nobutake Suzuki1, Mai Yamagishi3, Takashi Funatsu3,
Etsushi Kuroda2, Yoshitaka Shirasaki1
1

RCAST, The University of Tokyo, 2Department of Immunology, Hyogo Medical
University, 3Live Cell Diagnosis, Ltd.
11:10 ～ 11:20 フラッシュプレゼンテーション
11:20 ～ 11:55 日本免疫毒性学会総会（兼評議員会）

14

11:55 ～ 12:55 ランチョンセミナー＜ LS-01 ＞
座長：黒田悦史（兵庫医科大学）
LS-01 慢性炎症性疾患としてのアスベスト関連疾患の病態と最新の治療トピックス○南俊行1,2、多田陽郎2、袮木芳樹1,2、藤本大智1,2、大搗泰一郎1,2、三上浩司1,2、高橋良1,2、栗林康造1,2、木島貴志1,2
1

兵庫医科大学医学部

呼吸器・血液内科学、2兵庫医科大学医学部

胸部腫瘍学特定講座＜休憩＞

平成記念会館ポスター会場
13:00 ～ 13:50 ポスター討論（一般）＜ P-01 ～ P-22 ＞
P-01

Siglec-14によるカーボンナノ材料認識機構○山口慎一朗、竹村実希、三輪佳蓮、中山勝文
立命館 大、薬P-02

ポリウレタン膜マイクロカプセルの経気道曝露が肺炎症に与える影響○柳澤利枝、小池英子、藤谷雄二、高澤嘉一、鈴木剛
国立環境研究所

P-03

マイクロプラスチック粒子が自然免疫および獲得免疫を介して気管支喘息に与える影響と粒子生体内局在の可視化○長尾慧1、宮坂奈津子1、大畑良子2、本田晶子3、石川良賀1、井上健一郎4、市瀬孝道1、
高野裕久1,2
1

京大院・地球環境学堂、2京先端大 ・ 国際学術、3京大院・工、4静岡県立大・看護

P-04

クラブ細胞除去マウスを用いた長期吸入ばく露試験による架橋型ポリアクリル酸の肺障害性の検討○西田千夏1、東秀憲1、友永泰介2、東泰幸3、森本俊規3、佐藤和真2、中村佑生子2、
和泉弘人2、矢寺和博3、森本泰夫21

産業医科大学 産業生態科学研究所 労働衛生工学、2産業医科大学 産業生態科学研究所 呼吸病態学、3産業医科大学 医学部 呼吸器内科学

P-05

呼吸器と皮膚感作性物質の識別を目指した2ステップDC/T細胞共培養系の開発○溝口出、片平泰弘、長谷川英哲、善本隆之
東京医科大学 医学総合研究所 免疫制御研究部門

15

P-06

胎盤細胞における非晶質ナノシリカの炎症反応と胎盤障害との連関解析○東阪和馬1,2,3、山本怜奈3、芹澤杏萌3、芳賀優弥2,3、堤 康央2,3,4,5
1

P-07

阪大高等共創研、2阪大院薬、3阪大薬、4阪大MEIセ、5阪大先導

重症薬疹患者の臨床的特徴～全国症例ネットワークを用いた解析より～
塚越絵里、中村亮介、佐井君江、花尻（木倉）瑠理、○斎藤嘉朗
国立医薬品食品衛生研究所

P-08

HLAとβ2-microglobulinの結合有無によるHLA発現様式の違いと免疫毒性的意義の考察
野中麻衣1、戸田有紀1、梅澤啓太郎2、中村亮介3,4、荒川憲昭3、孫雨晨3、三浦ゆり2、伊藤晃成1、○青木重樹1
1

千葉大薬、2都健康長寿医セ研・プロテオーム、3国立衛研、4帝京大薬

P-09

HLA クラスⅠ提示ペプチドの簡便な解析系の開発
伊藤蒼1,2、○中村亮介1,2,3、荒川憲昭1、橋本由弥1、青木重樹4、伊藤晃成4、花尻瑠理1、斎藤嘉朗1,2
1

国立医薬品食品衛生研究所、2岡山大学大学院医歯薬学総合研究科、3帝京大学薬学部、
千葉大学薬学部

4

P-10

Non-specific binding of antibodies induces immunogenicity via unintended immune
activation〇Eiichi Hashimoto1, Shohei Kawarada2, Shunsuke Ito1, Nobuo Sekiguchi2, Hikaru Koga2,
Shiho Ohtsu2, Jumpei Kiyokawa1, Hiromi Suzuki1, Chiyomi Kubo1
1

Translational Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan,
Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan

2

P-11

GPC3-Dual抗体のcytokine release減弱におけるCD137シグナルの寄与○原田麻子、藤澤希望、松下智哉、岩田良香、池上仁
中外製薬株式会社 Translational Research本部 安全性バイオサイエンス研究部

P-12

Changes in Expression of Specific mRNA Transcripts in Mouse Testes after Singleor Re-Irradiation〇Ning Qu1,2, Kenta Nagahori2, Kaori Suyama2, Hayato Terayama2,3, Daisuke Kiyoshima2,
Shogo Hayashi2, Kou Sakabe3, Takayuki Yoshimoto1
1

Department of Immunoregulation, Institute of Medical Science, Tokyo Medical
University, 2Department of Anatomy, Division of Basic Medical Science, Tokai University
School of Medicine, 3Department of Environmental Preventive Medicine (Yamada Bee
Company, Inc.), Center for Preventive Medical Sciences, Chiba University

16

P-13

Self-assembling peptide CK2 contributes to the induction of antigen-specific cytotoxic
Tlymphocyte as a carrier of adjuvant and antigen〇Koubun Yasuda1, Miya Fujimoto2, Etsushi Kuroda1
1

P-14

Dept Immunol., Hyogo Med Univ, 2Menicon Co., Ltd.

Analysis of a novel necroptosis-inducing mucosal adjuvant○Takumi Adachi1, Kazufumi Matsushita1, Koubun Yasuda1, Masakiyo Nakahira1,
Mai Imasaka2, Zhuohao Yang3, Masaki Ohmuraya2, Yoshitaka Shirasaki3, Etsushi Kuroda1
1

Department of Immunology, School of Medicine, Hyogo Medical University, Hyogo, Japan,
Department of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan,
3
RCAST, The University of Tokyo, Meguro-ku, Tokyo, Japan2

P-15

Introduction of sugar-modified nucleotides into CpG-containing antisense
oligonucleotides inhibits TLR9 activation〇Tokuyuki Yoshida1, Tomoko Hagihara2, Yasunori Uchida1, Yoshiyuki Horiuchi2,
Kiyomi Sasaki1, Takenori Yamamoto1, Takuma Yamashita1, Yukihiro Goda1,
Yoshiro Saito1, Takao Yamaguchi3, Satoshi Obika3, Seiji Yamamoto2, Takao Inoue1
1

NIHS, 2Fuso Pharmaceutical Industries, 3Grad. Sch. Pharm. Sci., Osaka Univ

P-16

SARS-CoV-2 mRNAワクチンの新規安全性評価法の開発○平賀孔、百瀬暖佳、櫻木小百合、野島清子、石井美枝子、今井恵子、前山順一、関洋平、
倉光球、水上拓郎
国立感染症研究所 次世代生物学的製剤研究センター

P-17

遺伝子バイオマーカーを用いたウサギ発熱試験in vitro 代替法の開発○佐々木永太1、前山順一2、浅沼秀樹3、濱口功2、高橋宜聖1
1

感染研 治療薬・ワクチン開発研究センター、2感染研 次世代生物学的製剤研究センター、
3
感染研 インフルエンザ・呼吸器系ウイルス研究センター

P-18

亜鉛欠乏がOVA特異的抗体産生に与える影響○木戸尊將1、柳澤裕之2、斎藤三郎2、須賀万智11

東京慈恵会医科大学 医学部 環境保健医学講座、2東京慈恵会医科大学

P-19

加齢によって産生増大したIL-18はTh17 型気道炎症を増強する○中平雅清、黒田悦史
兵庫医科大、医学部、免疫学

17

P-20

無機ヒ素曝露により肝細胞株Huh7と肝星細胞株LX-2で誘導されるSASP因子の発現比較○岡村和幸1、鈴木武博1、中嶋信美2
1

P-21

国立環境研究所、環境リスク・健康領域、2国立環境研究所、生物多様性領域

Tyk2欠損マクロファージにおける糖化ストレス抵抗性の増強○室本竜太、美濃口広弥、阿部丈一朗、松田正
北大院薬

P-22

悪性中皮腫の治療奏効に関わるNK細胞の特徴的遺伝子発現動態および腫瘍細胞におけるNKp46リガンド発現○西村泰光1、山内明2、亀崎彩紗1、伊藤達男11

川崎医科大学、衛生学、2川崎医科大学、生化学

13:00 ～ 13:50 ポスター討論（若手）＜ Y-01 ～ Y-12 ＞
Y-01

乳酸チタン錯体を用いた新規チタンアレルギーマウスモデルの作製〇齋藤佐英子1,2、黒石智誠1、江草宏2、菅原俊二1
東北大院歯、1口腔分子制御、2分子・再生歯科補綴学

Y-02

Differential Impacts of Various Environmental Particles on Bronchus-AssociatedLymphoid Tissue Formation in Asthmatic Mice Model〇Wei Liu1, Raga Ishikawa2, Akiko Honda1, Takamichi Ichinose2, Binyang Qiu1,
Oluwatoyin Hannah Owokoniran2, Tomonari Matsuda1,3, Hirohisa Takano2,4
1

Grad. Sch. of Eng., Kyoto Univ., 2Grad. Sch. of Global Environ. Studies, Kyoto Univ., 3Res.
Ctr. for Environ. Qual. Mgmt., Kyoto Univ., 4Inst. for Int. Acad. Res., Kyoto Univ. of Adv.
Sci.

Y-03

DNA修復の機能不全によるDNA鎖切断を伴わない自然免疫応答メカニズムの解明○田中陽菜1、山北啓吾1、安井学2、本間正充2、杉山圭一2、藤木亮次3、金田篤志3,4、菅澤薫5、
浦聖恵1、佐々彰1
1

千葉大学大学院融合理工学府、2国立医薬品食品衛生研究所ゲノム安全科学部、3千葉大学
大学院医学研究院、4千葉大学健康疾患オミクスセンター、5神戸大学バイオシグナル総合研
究センター
Y-04

Chlorella sorokiniana はかび毒のデオキシニバレノールに吸着し、体内吸収を抑制することで、デオキシニバレノール経口曝露により増悪する皮膚アレルギー症状を軽減する○樋渡哲太¹、松坂怜央¹、大平智春¹、金木真央¹、小川太郎２、中島綾香２、福山朋季¹¹麻布大学 薬理学研究室、２株式会社ユーグレナ

学生・若手セッション＜ Y-05 ～ Y-12 ＞ にて口頭発表される内容を、ポスターでもご発表いただきます。学生・若手優秀発表賞は、口頭とポスター両方の内容を考慮して選考されます。

18

平成記念会館メイン会場
13:55 ～ 14:55 特別講演１＜ SL-01 ＞
座長：足利太可雄（国立医薬品食品衛生研究所）
SL-01 呼吸器感作性評価法の開発○善本隆之、片平泰弘、長谷川英哲、溝口出
東京医科大学 医学総合研究所 免疫制御研究部門＜休憩＞
15:05 ～ 16:35 シンポジウム１＜ S-01 ～ S-03 ＞「環境とアレルギー

最新知見」

座長：柳澤利枝（国立環境研究所）、福山朋季（麻布大学獣医学部）
S-01

環境因子による上皮バリア破壊とアレルギー性炎症○森田英明1,2
1

国立成育医療研究センター 免疫アレルギー・感染研究部、2国立成育医療研究センター ア
レルギーセンター
S-02

Molecular and cellular mechanisms through which tissue-resident memory T cells
drive refractory disease formation〇Kiyoshi Hirahara
Department of Immunology, Graduate School of Medicine, Chiba University

S-03

マウスモデルを用いたアレルギー性鼻炎の増悪・防御因子の探索○松下一史
兵庫医大、医、免疫学＜休憩＞
16:45 ～ 17:45 特別講演２＜ SL-02 ＞
座長：西村泰光（川崎医科大学）
SL-02 Regulation of Intestinal Macrophage and CD4 T Cell Differentiation in Autoimmunity:
The Role of Aryl Hydrocarbon Receptor-Microbiome Interactions.
○Allison K Ehrlich
Department of Environmental Toxicology, University of California Davis

日本盛
18:30 ～ 20:30 懇 親会
学生・若手優秀発表賞

授賞式
19

酒蔵通り煉瓦館

花さかり

第 2 日目

9 月 20 日（金）平成記念会館メイン会場

8:50 ～ 9:50

一般演題２＜ O-03 ～ O-06 ＞

座長：木戸尊將（東京慈恵会医科大学）、室本竜太（北海道大学大学院薬学研究院）
O-03

ゼブラフィッシュのミクログリア形態を指標とする神経毒性評価手法の開発○西村有平、弓削瑞葵、白水崇、小岩純子
三重大、医、統合薬理O-04

クッパー細胞におけるCCL3-CCR5 システムはアセトアミノフェン誘発急性肝障害に有害な作用を持つ○Yuko Ishida, Yumi Kuninaka, Mizuho Nosaka, Akihiko Kimura, Naofumi Mukaida,Toshikazu Kondo
Department of Forensic Medicine, Wakayama Medical University.

O-05

Study of the effect of 15-hydroxyprostaglandin dehydrogenase inhibition on
acetaminophen-induced acute liver injury○Hiroaki Shimada, Akito Yokotobi, Atsushi Kawase, Fuminori Sakurai
Biopharm, Kindai Univ.

O-06

Immunological characterization of peritoneal exudate cells in liver cirrhosis patients〇Shiori Kaji1, Izumi Sasaki2, Satoko Kunimoto3, Emi Tosuji4, Takashi Kato5,
Daisuke Okuzaki6, Masayuki Kitano1, Tsuneyasu Kaisho2
1

Second Department of Internal Medicine, Wakayama Med Univ, 2Department of
Immunology, Institute of Advanced Medicine, Wakayama Med Univ, 3Department ofNephrology, Wakayama Med Univ, 4Department of Dermatology, Wakayama Med Univ,
5
Department of Rheumatology and Clinical Immunology, Wakayama Med Univ, 6WPIImmunology Frontier Research Center, Osaka Univ
9:50 ～ 10:50

一般演題 3 ＜ O-07 ～ O-10 ＞

座長：黒石智誠（東北大学大学院歯学研究科）、中山勝文（立命館大学薬学部）
O-07

腹腔常在マクロファージにおけるパイリンインフラマソーム活性化機構の特異性○塔筋恵実1、加治汐梨2、佐々木泉3、西山奈央子3、改正恒康31

和歌山県立医科大学皮膚科学講座、2和歌山県立医科大学内科学第二講座、3和歌山県立医科大学先端医学研究所生体調節機構研究部
O-08

Inhibition of AIM2 inflammasome improves antimicrobial-resistant Staphylococcus
aureus infection〇Hideki Hara
Infect Dis, Asahikawa Med Univ
20

O-09

黄砂粒子による肺の急性炎症のメカニズムに関する検討○佐川友哉1,2、市瀬孝道1、本田晶子3、黒田悦史4、石川良賀1、宮坂奈津子1、長尾慧1、
奥田知明5、高野裕久1,6
1

京大院、地球環境、2京府医大院、免内、3京大院、工、4兵医大、免疫、5慶應大、理工、6京
先端大、国際学術
O-10

Bisphenol A Triggers the Activation of Ocular Immune System and Induces Allergic
Airway Inflammation〇Tatsuo Ueda1,2, Takumi Adachi1, Eiko Koike3, Rie Yanagisawa3, Kenzo Tsuzuki2,
Etsushi Kuroda1
1

Department of immunology, Hyogo Medical University, 2Department ofOtorhinolaryngology-Head and Neck Surgery, Hyogo Medical University, 3Health andEnvironmental Risk Division, National Institutes for Environmental Studies＜休憩＞
11:05 ～ 12:05 特別講演３＜ SL-03 ＞
座長：吉岡靖雄（大阪大学微生物病研究所）
SL-03 アジュバント分子発現弱毒生ワクチンによるエイズ予防・治療ワクチンの開発○保富康宏1,2,3,4,5
1

医薬基盤・健康・栄養研究所、2筑波大学協働大学院、3三重大学大学院医学系研究科、
4
大阪大学大学院薬学系研究科、5東京医科歯科大学大学院医歯学総合研究科
12:05 ～ 12:50 ランチタイム & ビジネスタイム
12:50 ～ 12:55 表彰式
12:55 ～ 13:20 学会賞受賞講演＜ AL-01 ＞
座長：中村亮介（帝京大学薬学部）
AL-01 環境との相互作用の中で生命を衛る医学の源流：免疫毒性学 ー細分化された研究から統合的視点をもった研究へー○吉田貴彦
旭川医科大学21

13:20 ～ 13:45 奨励賞受賞講演＜ AL-02 ＞
座長：中村亮介（帝京大学薬学部）
AL-02 Molecular mechanisms of pathogen sensors-mediated cytokine production frominnate immune cells〇Izumi Sasaki
Department of Immunology, Institute of Advanced Medicine, Wakayama Medical
University.
＜休憩＞
13:50 ～ 15:20 シンポジウム２＜ S-04 ～ S-06 ＞「新しいワクチン・免疫療法の有効性と安全性」
座長：立花雅史（立命館大学生命科学部）、武村直紀（大阪大学大学院薬学研究科）
S-04

CpG ODN-mediated immunoprophylaxis against viral infection〇Kouji Kobiyama1,2
1Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo,
International Vaccine Design Center, The Institute of Medical Science, The University of
Tokyo

2

S-05

Ⅰ型アレルギーに対する免疫療法の最新知見○土井雅津代
鳥居薬品（株）イノベーションリサーチ部

S-06

重症熱性血小板減少症候群に対する新規mRNAワクチンの非臨床免疫原性及び感染予防効果○江頭志織1,2、吉川禄助3,4、野草晶子1、山口綾1、小野寺宜郷1、城内直1、武下文彦1、黒田悦史2、安田二朗3,4
1

第一三共株式会社、2兵庫医科大学 医学部 免疫学講座、3長崎大学 熱帯医学研究所 新興感染症学分野、4長崎大学 高度感染症研究センター 新興ウイルス研究分野＜休憩＞
15:30 ～ 16:50 試験法ワークショップ＜ WS-01 ～ WS-03 ＞「免疫原性評価」
座長：松村匠悟（アステラス製薬株式会社）、坂入鉄也（田辺三菱製薬株式会社）
WS-01 バイオ医薬品の免疫原性リスク低減のための規制要件と予測・評価法に関する現状と課題○石井明子、青山道彦、鈴木琢雄、柴田寛子
国立医薬品食品衛生研究所・生物薬品部

22WS-02 バイオ医薬品の免疫原性評価戦略及び事例紹介○浜村えり、間哲生、後藤浩一、土屋由美
第一三共株式会社 安全性研究所
WS-03 Immunogenicity assessment and de-immunization strategy of engineered therapeutic
antibodies〇Eiichi HashimotoTranslational Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan
総合討論
16:50 ～ 17:00 年会賞授賞式、閉会式

23

Program
Day 1: September 19th (Thursday)
Heisei Memorial Hall, Main Hall
9:00 ～ 9:10

Opening Remarks

The 31st Annual Meeting of The Japanese Society of Immunotoxicology
President：Etsushi Kuroda
9:10 ～ 10:30

Students and Young Scientists Session ＜ Y-05 ～ Y-12 ＞

Chairpersons: S higeki Aoki（Graduate School of Pharmaceutical Sciences, Chiba University），
Izumi Sasaki（Institute of Advanced Medicine, Wakayama Medical University）
Y-05

Carbon black nanoparticles induce cytotoxic responses in alveolar macrophages〇Tomohiro Ishihara, Atsushi Furukawa, Yuka Nagata, Ryo Suzuki
Fac Pharm Sci, Kanazawa Univ

Y-06

The novel evaluation approach for the immunotoxicity of environmental particulatematters using a newly developed macrophage line
〇Hinata Inoue1,2, Takumi Adachi1, Etsushi Kuroda1
1

Department of Immunology, Hyogo Medical University, 2physician-scientist training
program, Hyogo Medical University
Y-07

Antagonistic activity of combined exposure to mycotoxins Nivalenol andDeoxynivalenol on the inflammatory cytokine production in dendritic cells〇Reo Matsuzaka1, Kazutoshi Sugita2, Shiro Miyake3, Tomoki Fukuyama1
1

Pharmacology lab, Vet Med, Azabu Univ., 2Public Health lab, Azabu Univ., 3Food andHygiene lab, Azabu Univ.
Y-08

Co-culture of corneal epithelial cells and neutrophil-like cells induces synergistic
production of inflammatory cytokines and chemokines〇Zirui Zeng1, Duo Wang2, Chieri Murayama3, Junnosuke Morita3, Tomoaki Okuda4,
Tatsuya Mimura5, Yasuhiro Yoshida3
1-3

Univ. Occ. Env. Hlth., Dept. of 11st. int. med., 2radi. Manage., 3imm. and para., 4Dept. ofApplied Chem., Fac. of Sci. and Tech., Keio Univ., 5Dept. of opht. Teikyo Univ.

24

Y-09

Analysis of the crosstalk between MyD88-TRAF6 signaling and AhR○Ryo Hakota1, Wataru Murase1, Ayaka Yasuda1, Atsuhito Kubota2, Tsugumi Shindo2,
Shirou Tsuchida2, Hiroyuki Kojima1,2, Koji Nakagawa1,2
1

Grad. Sch. Pharm. Sci., Health Sci. Univ. Hokkaido., 2Sch. Pharm. Sci., Health Sci. Univ.
Hokkaido.
Y-10

Type I IFNs attenuate efficacy of adenovirus vector-based intranasal vaccine〇Hayato Nakatani1, Masashi Tachibana1,2, Rika Onishi1, Kahori Shimizu1,
Fuminori Sakurai1, Hiroyuki Mizuguchi1,3,4,5,6
1

Grad Sch Pharm Sci, Osaka Univ, 2Col Life Sci, Ritsumeikan Univ, 3NIBIOHN, 4MEI cent,5
OTRI, 6CiDER, Osaka Univ

Y-11

Uncovering the role of nucleic acid sensors in innate immune responses triggered by
DNA strand breaks〇Nao Terakoshi1, Keigo Yamakita1, Manabu Yasui2, Masamitsu Honma2,
Kei-ichi Sugiyama2, Kaoru Sugasawa3, Kiyoe Ura1, Akira Sassa1
1

Grad. Sch. Sci., Chiba Univ., 2Div. Genome Safety Sci., Natl. Inst. Health. Sci., 3Biosignal
Res. Ctr., Kobe Univ.

Y-12

Effects of per- and polyfluoroalkyl substances (PFAS) on in vitro cytokine andantibody production in mouse immune cells〇Wataru Murase1, Atsuhito Kubota2, Ryuta Muromoto3, Akira Kubota4,
Kouichi Yoshinari5, Yu Ait Bamai6, Hiroyuki Kojima1,2
1Grad. Sch. Pharm. Sci., Health Sci. Univ. Hokkaido, 2Sch. Pharm. Sci., Health Sci. Univ.
Hokkaido, 3Grad. Sch. Pharm. Sci., Hokkaido Univ., 4Dept. Vet. Med., Obihiro Univ. Agr.
Vet. Med., 5Sch. Pharm. Sci., Univ. Shizuoka, 6Ctr. Env. Health Sci., Hokkaido Univ.
＜Break＞
10:40 ～ 11:10 Oral Presentation 1 ＜ O-01 ～ O-02 ＞
Chairperson: Atsuhito Kubota（School of Pharmaceutical Sciences, Health Sciences
University of Hokkaido）
O-01

Pulmonary adenoviral vectors induce persistent non-inflammatory immune responses
in lung that correlate with protective antibody responses〇Toshiro Hirai1,2,3,4, Koki Ueda2,3, Mako Kakihara2,3, Kazuo Takayama5,
Yasuo Yoshioka1,2,3,4,6,7,8
1

OTRI, Osaka Univ, 2RIMD, Osaka Univ, 3Pharm Sci, Osaka Univ, 4CAMaD, Osaka Univ,
5
CiRA, Kyoto Univ, 6BIKEN, 7MEI, Osaka Univ, 8CiDER, Osaka Univ

25

O-02

Imaging inflammatory response of mouse alveolar macrophage induced byenvironmental particulates using Live FluoroSpot〇Zhuohao Yang1, Takumi Adachi2, Nobutake Suzuki1, Mai Yamagishi3, Takashi Funatsu3,
Etsushi Kuroda2, Yoshitaka Shirasaki1
1

RCAST, The University of Tokyo, 2Department of Immunology, Hyogo College ofMedicine, 3Live Cell Diagnosis, Ltd.
11:10 ～ 11:20 Flash Presentation
11:20 ～ 11:55 General Assembly
11:55 ～ 12:55 Luncheon Seminar ＜ LS-01 ＞
Chairperson: Etsushi Kuroda（Hyogo Medical University）
LS-01 Current perspectives of asbestos-related disease as chronic inflammatory disorders.
○Toshiyuki Minami1,2, Akio Tada1, Yoshiki Negi1,2, Daichi Fujimoto1,2, Taiichiro Otsuki1,2,
Koji Mikami1,2, Ryo Takahashi1,2, Kozo Kuribayashi1,2, Takashi Kijima1,2
1

Department of Respiratory Medicine and Hematology, Hyogo Medical University,
Department of Thoracic Oncology, Hyogo Medical University

2＜Break＞

Heisei Memorial Hall, Poster Venue
13:00 ～ 13:50 Poster Discussion Session ＜ P-01 ～ P-22 ＞
P-01

Siglec-14 recognition of carbon nanomaterials〇Shin-Ichiro Yamaguchi, Miki Takemura, Karen Miwa, Masafumi Nakayama
Grad. Sch. Pharm. Sci., Ritsumeikan Univ.

P-02

Effects of intratracheal exposure to polyurethane membrane microcapsules in mice.
〇Rie Yanagisawa, Eiko Koike, Yuji Fujitani, Yoshikatsu Takazawa, Go Suzuki
National Institute for Environmental Studies

P-03

Effects of microplastic particles on bronchial asthma via innate and acquired
immunity and visualization of particle localization〇Megumi Nagao1, Natsuko Miyasaka1, Ryoko Ohata2, Akiko Honda3, Raga Ishikawa1,
Kenichiro Inoue4, Takamichi Ichinose1, Hirohisa Takano1,2
1

Grad. Sch. of Global Environ. Studies, Kyoto Univ., 2Inst. for Int. Acad. Res., Kyoto Univ.
of Adv. Sci., 3Grad. Sch. of Eng., Kyoto Univ., 4Sch. of Nursing, Shizuoka Pref. Univ.

26

P-04

Lung disorder of cross-linked polyacrylic acid in long-term inhalation exposure using
club cell-ablated mice
〇Chinatsu Nishida1, Hidenori Higashi1, Taisuhe Tomonaga2, Yasuyuki Higashi3,
Toshiki Morimoto3, Kazuma Sato2, Yuiko Nakamura2, Hiroto Izumi2, Kazuhiro Yatera3,
Yasuo Morimoto2
1

Department of Environmental Health Engineering, Institute of Industrial Ecological
Sciences, University of Occupational and Environmental Health, Japan, 2Departmentof Occupational Pneumology, Institute of Industrial Ecological Sciences, University ofOccupational and Environmental Health, Japan, 3Department of Respiratory Medicine,
University of Occupational and Environmental Health, Japan.
P-05

Development of a two-step DC/T cell coculture system to discriminate respiratory
sensitizers from skin sensitizers〇Izuru Mizoguchi, Yasuhiro Katahira, Hideaki Hasegawa, and Takayuki Yoshimoto
Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University

P-06

Study of the inflammatory response of silica nanoparticles in trophoblast cells〇Kazuma Higashisaka1,2,3, Rena Yamamoto3, Momoe Serizawa3, Yuya Haga2,3,
Yasuo Tsutsumi2,3,4,5
1

IACS., Osaka Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ., 3 Sch. Pharm. Sci., Osaka Univ.,
4
MEI Ctr, Osaka Univ., 5OTRI., Osaka Univ.

P-07

Clinical characteristics of patients with severe cutaneous adverse reactions - Ananalysis from a national case collection network
Eri Tsukagoshi, Ryosuke Nakamura, Kimie Sai, Ruri Kikura-Hanajiri, 〇Yoshiro Saito
Natl Inst Health Sci

P-08

Consideration of the impact of the differences in HLA expression patterns due to thepresence or absence of β2-microglobulin binding on immunotoxicity
Mai Nonaka1, Yuki Toda1, Keitaro Umezawa2, Ryosuke Nakamura3,4, Noriaki Arakawa3,
Yuchen Sun3, Yuri Miura2, Kousei Ito1, 〇Shigeki Aoki1
1

Grad Sch of Pharm Sci, Chiba Univ, 2Proteome, TMIG, 3Natl Inst Health Sci, 4Pharm Sci,
Teikyo Univ

P-09

Development of a Simple Analysis System for HLA Class I-Presented Peptides
Aoi Ito1,2, ○Ryosuke Nakamura1,2,3, Noriaki Arakawa1, Yuya Hashimoto1, Shigeki Aoki4,
Kousei Ito4, Ruri Kikura-Hanajiri1, Yoshiro Saito1,2
1Natl Inst Health Sci, 2Okayama Univ, 3Teikyo Univ, 4Chiba Univ.

27

P-10

Non-specific binding of antibodies induces immunogenicity via unintended immune
activation〇Eiichi Hashimoto1, Shohei Kawarada2, Shunsuke Ito1, Nobuo Sekiguchi2, Hikaru Koga2,
Shiho Ohtsu2, Jumpei Kiyokawa1, Hiromi Suzuki1, Chiyomi Kubo1
1

Translational Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan,
Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan

2

P-11

T-cell activation by CD137 contributes to decreased cytokine release of CD3/CD137
T-cell engager, GPC3-Dual〇Asako Harada, Nozomi Fujisawa, Tomochika Matsushita, Yoshika Iwata,
Hisashi Ikegami
Chugai Pharmaceutical Co., Ltd.

P-12

Changes in Expression of Specific mRNA Transcripts in Mouse Testes after Singleor Re-Irradiation〇Ning Qu1,2, Kenta Nagahori2, Kaori Suyama2, Hayato Terayama2,3, Daisuke Kiyoshima2,
Shogo Hayashi2, Kou Sakabe3, Takayuki Yoshimoto1
1

Department of Immunoregulation, Institute of Medical Science, Tokyo Medical
University, 2Department of Anatomy, Division of Basic Medical Science, Tokai University
School of Medicine, 3Department of Environmental Preventive Medicine (Yamada Bee
Company, Inc.), Center for Preventive Medical Sciences, Chiba University

P-13

Self-assembling peptide CK2 contributes to the induction of antigen-specific cytotoxic
Tlymphocyte as a carrier of adjuvant and antigen〇Koubun Yasuda1, Miya Fujimoto2, Etsushi Kuroda1
1

P-14

Dept Immunol., Hyogo Med Univ, 2Menicon Co., Ltd.

Analysis of a novel necroptosis-inducing mucosal adjuvant○Takumi Adachi1, Kazufumi Matsushita1, Koubun Yasuda1, Masakiyo Nakahira1,
Mai Imasaka2, Zhuohao Yang3, Masaki Ohmuraya2, Yoshitaka Shirasaki3, Etsushi Kuroda1
1

Department of Immunology, School of Medicine, Hyogo Medical University, Hyogo, Japan,
Department of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan,
3
RCAST, The University of Tokyo, Meguro-ku, Tokyo, Japan2

P-15

Introduction of sugar-modified nucleotides into CpG-containing antisense
oligonucleotides inhibits TLR9 activation〇Tokuyuki Yoshida1, Tomoko Hagihara2, Yasunori Uchida1, Yoshiyuki Horiuchi2,
Kiyomi Sasaki1, Takenori Yamamoto1, Takuma Yamashita1, Yukihiro Goda1,
Yoshiro Saito1, Takao Yamaguchi3, Satoshi Obika3, Seiji Yamamoto2, Takao Inoue1
1

NIHS, 2Fuso Pharmaceutical Industries, 3 Grad. Sch. Pharm. Sci., Osaka Univ

28

P-16

Development of new method for the evaluation of the safety and quality control of
SARS-Cov-2 mRNA vaccine〇Kou Hiraga, Haruka Momose, Sayuri Sakuragi, Kiyoko Nojima, Mieko Ishii, Keiko Imai,
Junichi Maeyama, Yohei Seki, Madoka Kuramitsu, Takuo Mizukami
Research Center for Biological Products in the Next Generation, National Institute of
Infectious Diseases

P-17

Development of an In Vitro Alternative Method for Rabbit Pyrogen Test Using
Genetic Biomarkers〇Eita Sasaki1, Jun-ichi Maeyama2, Hideki Asanuma3, Isao Hamaguchi2,
Yoshimasa Takahashi1
1Research Center for Drug and Vaccine Development, NIID, 2Research Center for
Biological Products in the Next Generation, NIID, 3Center for Influenza and Respiratory
Virus Research, NIID
P-18

Effect of OVA-specific antibody production in the zinc deficiency〇Takamasa Kido, Hiroyuki Yanagisawa, Saburo Saito, Machi Suka
The Jikei University School of Medicine

P-19

Augmentation of Th17 cells-mediated airway inflammation by aging-related IL-18
production〇Masakiyo Nakahira, Etsushi Kuroda
Department of Immunology, Hyogo Medical University

P-20

Comparison of gene expression levels of SASP factors between hepatoma cell line
Huh-7 and hepatic stellate cell line LX-2 by arsenite exposure〇Kazuyuki Okamura1, Takehiro Suzuki1, Nobuyoshi Nakajima2
1

Health and Environmental Risk Division, National Institute for Environmental Studies,
Biodiversity Division, National Institute for Environmental Studies

2

P-21

Enhanced resistance to glycative stress in Tyk2-deficient macrophages〇Ryuta Muromoto, Hiroya Minoguchi, Joichiro Abe, Tadashi Matsuda
Grad. Sch. Pharm. Sci., Hokkaido Univ.

P-22

Characteristic gene expression kinetics of NK cells involved in treatment response tomalignant mesothelioma and NKp46 ligand expression in tumor cells〇Yasumitsu Nishimura1, Akira Yamauchi2, Ayasa Kamezaki1, Tatsuo Ito1
1

Dept. of Hygiene, Kawasaki Medical School, 2Dept. of Biochemistry, Kawasaki Medical
School29

13:00 ～ 13:50 Poster Discussion Session ＜ Y-01 ～ Y-12 ＞(Posters for Students and Young Scientist Session are also included in this session)
Y-01

Novel titanium-allergy mouse model using water-soluble Ti-lactic acid complex〇Saeko Saito1,2, Toshinobu Kuroishi1, Hiroshi Egusa2, Shunji Sugawara1
1

Division of Oral Immunology, 2Division of Molecular and Regenerative Prosthodontics,
Tohoku University Graduate School of DentistryY-02

Differential Impacts of Various Environmental Particles on Bronchus-AssociatedLymphoid Tissue Formation in Asthmatic Mice Model〇Wei Liu1, Raga Ishikawa2, Akiko Honda1, Takamichi Ichinose2, Binyang Qiu1,
Oluwatoyin Hannah Owokoniran2, Tomonari Matsuda1,3, Hirohisa Takano2,4
1

Grad. Sch. of Eng., Kyoto Univ., 2Grad. Sch. of Global Environ. Studies, Kyoto Univ., 3Res.
Ctr. for Environ. Qual. Mgmt., Kyoto Univ., 4Inst. for Int. Acad. Res., Kyoto Univ. of Adv.
Sci.

Y-03

Mechanism of innate immun response without DNA strand breaks due todysfunctional DNA repair〇Hina Tanaka1, Keigo Yamakita1, Manabu Yasui2, Masamitsu Honma2, Kei-ichi Sugiyama2,
Ryoji Fujiki3, Atsushi Kaneda3,4, Kaoru Sugasawa5, Kiyoe Ura1, Akira Sassa1
1

Grad. Sch. Sci., Chiba Univ., 2 Div. Genome Safety Sci., Natl. Inst. Health. Sci., 3Grad. Sch.
Med., Chiba Univ., 4Health and Disease Omics Center., Chiba Univ., 5 Biosignal Res. Ctr,
Kobe Univ.
Y-04

Deoxynivalenol detoxification by Chlorella sorokiniana leads to inhibitory effects on
the Deoxynivalenol induced allergic contact dermatitis symptoms in a mouse model.
〇Tetta Hiwatashi1, Reo Matuzaka1, Chiharu Ohira1, Mao Kaneki1, Taro Ogawa2,
Ayaka Nakashima2, Tomoki Fukuyama1
1

Pharmacology lab, Vet Med, Azabu Univ, 2Euglena Co., Ltd.

Heisei Memorial Hall, Main Hall
13:55 ～ 14:55 Special Lecture 1 ＜ SL-01 ＞
Chairperson: Takao Ashikaga（National Institute of Health Sciences）
SL-01 Development of methods for assessing respiratory sensitizing potential〇Takayuki Yoshimoto, Yasuhiro Katahira, Hideaki Hasegawa, Izuru Mizoguchi
Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University＜Break＞

30

15:05 ～ 16:35 Symposium 1 ＜ S-01 ～ S-03 ＞「Environment and Allergy: Latest Findings」
Chairpersons: R
 ie Yanagisawa（National Institute for Environmental Studies），
Tomoki Fukuyama（Department of Veterinary Medicine, Azabu University）
S-01

Environmental factors that disrupt the epithelial barrier, leading to allergic
inflammation〇Hideaki Morita1,2
1Department of Allergy and Clinical Immunology, National Research Institute forChild Health and Development, 2Allergy Center, National Center for Child Health andDevelopment

S-02

Molecular and cellular mechanisms through which tissue-resident memory T cells
drive refractory disease formation〇Kiyoshi Hirahara
Department of Immunology, Graduate School of Medicine, Chiba University

S-03

Exploration of prevention/exacerbation factors for allergic rhinitis using mousemodels〇Kazufumi Matsushita
Department of Immunology, Hyogo Medical University School of Medicine＜Break＞
16:45 ～ 17:45 Special Lecture 2 ＜ SL-02 ＞
Chairperson: Yasumitsu Nishimura（Kawasaki Medical School）
SL-02 Regulation of Intestinal Macrophage and CD4 T Cell Differentiation in Autoimmunity:
The Role of Aryl Hydrocarbon Receptor-Microbiome Interactions.
○Allison K Ehrlich
Department of Environmental Toxicology, University of California Davis

Nihonsakari Sakagura Dori Rengakan Hanasakari
18:30 ～ 20:30 B anquetAward Ceremony for Students and Young Scientists

31Day 2: September 20th (Friday)
Heisei Memorial Hall, Main Hall
8:50 ～ 9:50

Oral Presentation 2 ＜ O-03 ～ O-06 ＞

Chairpersons: T akamasa Kido（The Jikei University School of Medicine），
Ryuta Muromoto（Faculty of Pharmaceutical Sciences, Hokkaido University）
O-03

Development of a novel image analysis of microglia in zebrafish to assess
neurotoxicity of chemicals〇Yuhei Nishimura, Mizuki Yuge, Takashi Shiromizu, Junko Koiwa
Department of Integrative Pharmacology, Mie University Graduate School of Medicine

O-04

CCL3-CCR5 axis in Kupffer cells plays a detrimental role in acetaminophen-induced
acute liver injury○Yuko Ishida, Yumi Kuninaka, Mizuho Nosaka, Akihiko Kimura, Naofumi Mukaida,Toshikazu Kondo
Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan

O-05

Study of the effect of 15-hydroxyprostaglandin dehydrogenase inhibition on
acetaminophen-induced acute liver injury○Hiroaki Shimada, Akito Yokotobi, Atsushi Kawase, Fuminori Sakurai
Biopharm, Kindai Univ.

O-06

Immunological characterization of peritoneal exudate cells in liver cirrhosis patients〇Shiori Kaji1, Izumi Sasaki2, Satoko Kunimoto3, Emi Tosuji4, Takashi Kato5,
Daisuke Okuzaki6, Masayuki Kitano1, Tsuneyasu Kaisho2
1

Second Department of Internal Medicine, Wakayama Med Univ, 2Department of
Immunology, Institute of Advanced Medicine, Wakayama Med Univ, 3Department ofNephrology, Wakayama Med Univ, 4Department of Dermatology, Wakayama Med Univ,
5
Department of Rheumatology and Clinical Immunology, Wakayama Med Univ, 6WPIImmunology Frontier Research Center, Osaka Univ
9:50 ～ 10:50

Oral Presentation 3 ＜ O-07 ～ O-10 ＞

Chairpersons: T oshinobu Kuroishi（Tohoku University Graduate School of Dentistry），
Masafumi Nakayama（College of Pharmaceutical Sciences, Ritsumeikan University）
O-07

The specificity of pyrin inflammasome activation in murine resident peritoneal
macrophages〇Emi Tosuji1, Shiori Kaji2, Izumi Sasaki3, Naoko Nishiyama3 and Tsuneyasu Kaisho3
1

Department of Dermatology, Wakayama Medical Univ (WMU), 2Second Department ofInternal Medicine, WMU, 3Department of Immunology, Institute of Advanced Medicine,
WMU

32

O-08

Inhibition of AIM2 inflammasome improves antimicrobial-resistant Staphylococcus
aureus infection〇Hideki Hara
Infect Dis, Asahikawa Med Univ

O-09

Study on the mechanism of acute lung inflammation caused by Asian sand dust
particles〇Tomoya Sagawa1,2, Takamichi Ichinose1, Akiko Honda3, Etsushi Kuroda4,
Raga Ishikawa1, Natsuko Miyasaka1, Megumi Nagao1, Tomoaki Okuda5, Hirohisa Takano1,6
1

Grad. Sch. of Global Environ. Studies, Kyoto Univ., 2Infl. and Immun., Grad. Sch. of Med.
Sci., Kyoto Pref. Univ. of Med., 3Grad. Sch. of Eng., Kyoto Univ., 4Dep. of Immun., Sch. ofMed., Hyogo Med. Univ., 5Facul., of Sci. and Tech., Keio Univ., 6Inst. for Int. Acad. Res.,
Kyoto Univ. of Adv. Sci.
O-10

Bisphenol A Triggers the Activation of Ocular Immune System and Induces Allergic
Airway Inflammation〇Tatsuo Ueda1,2, Takumi Adachi1, Eiko Koike3, Rie Yanagisawa3, Kenzo Tsuzuki2,
Etsushi Kuroda1
1

Department of immunology, Hyogo Medical University, 2Department ofOtorhinolaryngology-Head and Neck Surgery, Hyogo Medical University, 3Health andEnvironmental Risk Division, National Institutes for Environmental Studies＜Break＞
11:05 ～ 12:05 Special Lecture 3 ＜ SL-03 ＞
Chairperson: Yasuo Yoshioka（Research Institute for Microbial Diseases, Osaka University）
SL-03 Development of AIDS prevention and treatment vaccines using live attenuatedvaccines expressing adjuvant molecules〇Yasuhiro Yasutomi1,2,3,4,5
1

National Institutes of Biomedical Innovation, Health and Nutrition, 2School of Integrativeand Global Majors, University of Tsukuba, 3Mie University Graduate School of Medicine,
4
Osaka University Graduate School of Pharmaceutical Science, 5Tokyo Medical and Dental
University Graduate School of Medical and Dental Science
12:05 ～ 12:50 Lunch Time & Business Time
12:50 ～ 12:55 Awards Ceremony

33

12:55 ～ 13:20 JSIT Award Lecture ＜ AL-01 ＞
Chairperson: Ryosuke Nakamura（Faculty of Pharmacology, Teikyo University）
AL-01 Immunotoxicology; the origins of medicine that protects lives in interaction withenvironment －From segmented research to research with an integrated perspective－〇Takahiko Yoshida
Asahikawa Medical University
13:20 ～ 13:45 JSIT Young Investigator Award Lecture ＜ AL-02 ＞
Chairperson: Ryosuke Nakamura（Faculty of Pharmacology, Teikyo University）
AL-02 Molecular mechanisms of pathogen sensors-mediated cytokine production frominnate immune cells〇Izumi Sasaki
Department of Immunology, Institute of Advanced Medicine, Wakayama Medical
University.
＜Break＞
13:50 ～ 15:20 Symposium 2 ＜ S-04 ～ S-06 ＞「The Efficacy and Safety of New Vaccines and Immunotherapies」
Chairpersons: Masashi Tachibana（Department of Biomedical Sciences, College of Life
Sciences, Ritsumeikan University），
Naoki Takemura（Graduate School of Pharmaceutical Sciences, Osaka
University）
S-04

CpG ODN-mediated immunoprophylaxis against viral infection〇Kouji Kobiyama1,2
1Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo,
International Vaccine Design Center, The Institute of Medical Science, The University of
Tokyo

2

S-05

Disease modifying treatments: Allergy immunotherapy for type-1 allergy○Katsuyo Ohashi-Doi
Innovation Research Dep. Torii Pharmaceutical Co Ltd.

S-06

Preclinical immunogenicity and protective efficacy of new mRNA vaccines against
SFTS〇Shiori Egashira1,2, Rokusuke Yoshikawa3, Shoko Nogusa1, Aya Yamaguchi1,
Yoshikuni Onodera1, Nao Jonai1, Fumihiko Takeshita1, Etsushi Kuroda2, Jiro Yasuda3
1

Daiichi Sankyo Co., Ltd., 2Hyogo Medical University, 3Nagasaki University34

＜Break＞
15:30 ～ 16:50 Workshop ＜ WS-01 ～ WS-03 ＞「Immunogenicity Assessment」
Chairpersons: S
 hogo Matsumura（Astellas Pharma Inc.），
Tetsuya Sakairi（ Mitsubishi Tanabe Pharma Corporation）
WS-01 Current status and issues in prediction and evaluation of immunogenicity ofbiopharmaceuticals〇Akiko Ishii-Watabe, Michihiko Aoyama, Takuo Suzuki, Hiroko Shibata
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
WS-02 Strategy and case studies for assessing immunogenicity of biopharmaceuticals〇Eri Hamamura-Yasuno, Tetsuo Aida, Koichi Goto, Yoshimi Tsuchiya
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.
WS-03 Immunogenicity assessment and de-immunization strategy of engineered therapeutic
antibodies〇Eiichi HashimotoTranslational Research Division, Chugai Pharmaceutical Co., Ltd, Kanagawa, Japan
Discussion
16:50 ～ 17:00 A ward Ceremony for the Best Presenter of 31st Annual Meeting
Closing Remarks

35