The 12th Annual Meeting of JSIT
September 20-21, 2005, Tokyo Japan
President: Motoyasu Ohsawa (Faculty of Pharmaceutical Sciences, Teikyo University)
Keynote Lecture
Immunotoxicoliogy
Motoyasu Ohsawa
Research 2005 - A
perspective to integrated
understanding ofimmunotoxicities.

Dept. of Health Sciences,
Faculty of PharmaceuticalSciences, Teikyo University,
Sagamiko, Kanagawa, Japan

Special Lecture 1
Immunotoxicology oftherapeutics associatedwith allergy andautoimmunity

Raymond Pieters

Institute for Risk Assessment

Kanehisa Morimoto(1),Kunio Nakayama(1),(1)Department of Social andEnvironmental Medicine,

Sciences (IRAS)Immunotoxicology Utrecht
University, The Netherland

Special Lecture 2
Prevention System ofOccupational andEnvironmental Allergy
and Immunotoxicology

Atsushi Ueda(2)Osaka University Graduate
School of Medicine,(2)Department of Preventiveand Environmental Medicine,
Graduate School of Medical
and Pharmaceutical Sciences,
Kumamoto University, Japan

Symposium <1>
Nanoparticle andImmune System

Organizer

Hidekazu
FujimakiNational Institute forEnvironmental Studies,
Tsukuba, Japan

Masatoshi
BesshoTokyo University of Pharmacy
and LIfe Sciences, Tokyo,
Japan

Trends of nanoparticle
studies on health effectTskahiro Kobayashi

National Institute forEnvironmental StudiesDivision of Environmental
Health Sciences, Tsukuba,Japan

Effect of particulatematters on immune
system and oxidativestress

Eiko Koike

PM2.5 and DEP ResearchProject, National Institute forEnvironmental Studies,Tsukuba, Japan

Application of liposomes
for intracellular drugdeliveryKazuo Maruyama

Teikyo University Faculty of
Pharmaceutical sciences,
Tokyo, Japan

Encephalomyocarditis
virus infection andimmune system

Kunio Doi

Graduate School ofagriculture and LIfe
Sciences/Faculty ofAgriculture, The University ofTokyo, Tokyo, Japan
Symposium <2>
In Vitro

Organizer

Takemi Otsuki Department of Hygiene,

Immunotoxicology

Kawasaki Medical School,
Kurashiki, Japan
Fuminori

Dept. of Health Sciences,

OtsukaFaculty of PharmaceuticalSciences, Teikyo University,Tokyo, Japan

Cross-talk between

Kenji Izuhara, SachikoDepartment of Biomolecularinterleukin-4/13 signals
and dioxin

Kanaji, Go Tanaka

Sciences, Saga Medical
School, Saga, Japan

Effect of asbestos on

Takemi Otsuki(1), Yoshie(1)Department of Hygiene,

humanimmunocompetent cells

Miura(1), Yasumitsu
Nishimura(1), Fuminori
Hyodoh (1), Hironobu
Katsuyama(2), Masafumi
Tomita(3)(2)Department of Public
Health, (3)Department ofMedical Toxicology, Kawasaki
Medical School, Kurashiki,Japan

Ⅰ. Optimization ofprotocol and avalidation study
between twolaboratories

Hitoshi Sakaguchi(1),Takao Ashikaga(2)(1)Kao Corporation, Safety
and Microbial Control
Research Center, (2)ShiseidoCo., Ltd., Safety andAnalytical Research Center

Ⅱ. Study on doseresponse relationshipsof CD86/CD54
expression

Takao Ashikaga(1),Hitoshi Sakaguchi(2)(1) Shiseido Co., Ltd., Safety
and Analytical ResearchCenter, (2) Kao Corporation,
Safety and Microbial Control
Research Center

Chemokine release frommast cells byenvironmental chemicals
and biomarkers of mastcell activation

Reiko Teshima, Ryosuke
Nakamura, Jun-ichi
SawadaDivision of Biochemistry andImmunochemistry, National
Institute of Health Sciences,Tokyo, Japan

Organizer

Jun-ichi
SawadaDiv. Biochem. Immunochem.,
Nat1. Inst. Health Sci., Tokyo,
Japan

KazuichiNakamura

Developmental ResearchLaboratories, Shionogi & Co.,
Ltd., Osaka, Japan

In vitro skin sensitization
test using THP-1 cells(human monocyticleukemia cell line)

Workshop
Nobel Immunotoxicity

CLinicalimmunotoxicology ofbiomedicine -- antiRrheumatic drugs

Shiro Ueda

Drug Information andCommunication, Faculty of
Pharmaceutical Sciences,
Chiba University, Chiba,
Japan

Application oftoxicogenomics for

Keiko Nohara

Environmental Health
Sciences Division, National

evaluation of
immunotoxicity of

Institute for EnvironmentalStudies, Tsukuba, Japanenvironmental pollutants
Biological parameters

Setsuyta Aiba

Department of Dermatology,

usuful for evaluation of

Tohoku University Graduate

chmical sensitivity

School of Medicine, Sendai,
Japan.

Bioinformatics and

Ryosuke Nakamura,

Reiko Div. Biochem. Immunochem.,

allergenicity prediction

Teshima, Kayoko Takagi,

Nat1. Inst. Health Sci., Tokyo,

for food safety-Jun-ichi Sawada

Japan

ImmunotoxicityEvaluation in Rat Repeat
Dose Toxicity Study ofCyclosporin

Ai Minakawa, Hiroshi
Watanabe, Toshiyuki
Tsuchiya, Keiji Samura,
Masaru Nishikibe

Tsukuba Safety Assessment
Laboratories, Banyu
Pharmaceutical Co., Ltd.,
Tsukuba, Japan

Immunotoxicity
Evaluation in Rat Repeat
Dose Toxicity Study ofPrednisolone

Hiroshi Watanabe, AiMinakawa, Toshiyuki
Tsuchiya, Keiji Samura,
Masaru Nishikibe

Tsukuba Safety Assessment
Laboratories, Banyu
Pharmaceutical Co., Ltd.,
Tsukuba, Japan

A case of
Naohisa Tsutsui Hiroyuki
immunotoxicological
Harada Tetsuya Sakairi
evaluation forinvestigational new drugs

Toxicology Laboratory,Research and Development
Division, Mitsubishi Pharma
Corporation, Chiba, Japan

Murine Food Allergy
Model with Oral
Sensitization and Oral
Challenge(4)Tomoko Shindo(1),Yukiko Kanazawa(1),Mami Furuya(1),Yoshiyuki Tazura(1),Kohichi Kojima(1) ReikoTeshima(2)(1)Hatano Research Institute,
Food and Drug Safety Center,
Kanagawa, Japan,(2)National Institute of
Health Sciences, Tokyo, Japan

17β-Estradiol enhances
expression of proinflammatory cytokines

Humitoshi Sakazaki,
Masahiro Fujiyama,
Kazunori Fujii, Hitoshi

Division of Environmental
Health, Faculty of
Pharmaceutical Sciences,at inflamed area ofcontact hypersensitivity

Ueno, KatsuhikoNakamuro

Setsunan University, Osaka,Japan

The prolonged survival

Yasumitsu Nishimura(1),(1)Dept of Hygiene, Kawasaki

and the long-lastingproduction of TGF-betalin the alveolar

Tamako Nishiike-Wada(2), Medical School, Kurashiki,
Yasuhiko Wada(3), Yoshie Japan (2)Dept of Life-Design,
Miura(1)(4), Takemi
Otemae College, Itami, Japan

Construction of a novel
allergen database ADFSGeneral Oral Presentation

macrophages induced by Otsuki(1), Tomohide
the low exposure toHosokawa(4) Hiroshi(3)Dept of Environmental andPreventive Medicine, Hyogoasbestos

College of Medicine,
Nishinomiya, Japan (4)DeptIguchi(3)of Life Science, Kyoto
University of Education,Kyoto, Japan
Human arsenite-induced

Teruaki Sakurai(1),(1)Department of Medicalmacrophages(As-Mp)arestrongly activated byNorifumi Tomita(2),Hariya(2), Ayumu

Yukie Pharmacy, Faculty ofPharmaceutical Sciences,microbial products

Mizukami(2),Himeno(1)Seiichiro

Tokushima Bunri University,
Tokushima, Japan (2)Schoolof Life Science, Tokyo

University of Pharmacy andLife Science, Tokyo, JapanThe evaluation of thesafety of pigments andsynthetic resins

Masashi Tsunoda, Kyoko
Itoh, Yoko Inoue, Takeo
Miki, Yuichiro Kudo,

contained pigments using Toshihiko Satoh,murine macrophage cell Yoshiharu Aizawa

Department of Preventive
Medicine and Public Health,
Kitasato University School ofMedicine, Sagamihara, Japanline
Organophosphatepesticides affect theMaki Ikeda(1), Satoshi
Kawakami(1), Takehiro(1)School of Allied Health
Sciences, (2) School of

intracellular activation
signal in mitogenstimulated human blood

Kadowaki(1), Motoharu
Sakaue(2), Ryosuke
Nakamura(2), Masako

Pharmacetical Sciences,
Kitasato University, (3)TheKitasato Institutelymphocytes

Kiyono(2),(2)(3)Kou SakabeGeneral Poster Presentation
The immunotoxic effects

Ayako Nakayama(1),(1)Department ofof tributyltin on nonspecific biodefense
systems in fish using

Takako Tanigawa(1),Yuko Kurokawa(1),Toshiaki Miyadai(2),Environmental Science,
Faculty of Human Sciences,
Kobe College, Hyogo, Japan

flow cytometry

Tadahisa Seikai(2),ichiro Kawai(1)Shin-(2)Department of Marine
Bioscience, Faculty ofBiotechnology, Fukui
Prefectural University, Fukui,Japan

Effect of intranasal

Tin-Tin-Win-Shwe

National Institute for

instillation ofnanoparticle carbon black

Enviroenmental Studies,
Environmental Healthon neuro-immuneresponse in mice

Sciences Division, Tsukuba,Japan

Effect of scratching

Nobuhiro Goi et al

University of Shizuoka.,

behavior and Astressin:
CRH1/CRH2 receptor
antagonist on TH2

Shizuoka, Japan

cytokine production inspleen CD4+T cell.
Expression of NKT Cell in Kana Ogura(1),Masahiko (1)Department of GeriatricBone Marrow from
Suzuki(2), Etsuko
Patients with Rheumatoid Negishi(1), Hideshige
Arthritis

Moriya(2),Pharmacology andTherapeutics, Graduate

Koichi Ueno(1) School of PharmaceuticalSciences, Chiba University,Chiba, Japan (2)Departmentof Orthopedic Surgery,
Graduate School of MedicalSciences, Chiba University,Chiba, Japan

Comparison of dateobtained with in vitro

Hideki Miyaura,
Takeyoshi

Masahiro

Chemicals Evaluation andResearch Institute, Japan.

Study on theChie Yashiro(1),Kazuo(1)Faculty of Appliced

immunotoxicity of

Kobayashi-Hattori(1),skin sensitization test
used THP-1 cell line andnon-RI local lymph nodeassay
Bioscience, Tokyo University

mycotoxin in F1

Toshichika Takita(1),of Agriculture, Tokyo, Japangeneration

Yoshiko Sugita-Konishi(2)(2)Division of Microbiology,
National Institute of HealthSciences

Disruption of Mineral

Takao Kuriyama(1),homeostasis andappoptosis

ichi Tomiyama(1),Moritoshi Nihira(1),Ken-(1)Department of Hygiene &Preventive Medicine, Facultyof Health Sciences, The

Tomomi Jyoho(1),Takayuki Takeuchi(2),University of Shizuoka,
Shizuoka, Japan

Yukihiro Nakano(2),Harunobu Nakashima(3),(2)Research Reactor
Institute, Kyoto University

Yoshikazu Matsuda(4),Yasuaki Arakawa(1)(3)Osaka Prefectural Instituteof Public Health, (4)Central
Research Institute, Japan
Clinic Co., Ltd.

Inhibitory effect ofBacillus thuringensis

Kouya Yamaki,
YoshinoShin

toxin-containing
insecticide on induction

Department of Pharmacology,
Kobe PharmaceuticalUniversity, Kobe, Japanof oral tolerance
Alternation of Bcl-2

Yoshie Miura(1),(1)Dept. of Hygiene, (2)Dept.

expression in a humanYasumitsu Nishimura(1),polyclonal T cell line, MT- Hironobu Katsuyama(2),of Public Health, Kawasaki
Medical School, Kurashiki,2, after acquisition ofresistance to asbestos

Kozo Kuribayashi(3),Takashi Nakano(3),Japan (3)Dept. ofRespiratory Medicine, Hygo

Takumi Kishimoto(4),Fuminori Hyodoh(1),Takemi Otsuki(1)College of Medicine,
Nishinomiya, Japan(4)Okayama Rosai Hospital,Okayama, Japan

Organic extract of dieselexhaust particles

Hajime Aoyagi(1), EikoKoike(2), Takahiro(1)Master's Program inBiosystem Studies, University

stimulates Ia and B7
molecules in rat alveolar

Kobayashi(3)of Tsukuba, (2)PM2.5 and
DEP Research Project,macrophages andperipheral bloodmonocytes.

National Institute forEnvironmental Studies,Tsukuba, Japan(3)Environmental Health
Science Division, National
Institute for Environmental
Studies, Tsukuba, Japan

Study for immune cell-Haruko Nagai(1)(2),(1)Environmental Healthspecific changes in gene
expression by dioxins

Tomohiro Ito(1), ChiharuTohyama(3), Masato
Kubo(4), Ryo Abe(2),Sciences Division, National
Institute for Environmental
Studies, Tsukuba, Japan

Keiko Nohara(1)(2)Research Institute for
Biological Sciences, Science
University of Tokyo,(3)Center for Disease Biology
and Integrative Medicine,
Graduate School of Medicine,
University of Tokyo (4)Riken
Research Center for Allergy
and Immunology, RikenTopics

Trends inImmunotoxicology
Research in USA

Mitchell D. Cohen

Department of EnvironmentalMedicine, New York University
School of Medicine, Nelson
Institute of Environmental
Medicine, NY, U.S.A.