Master Course 2017-2018 - UAM
BMM11 module: Genetically Modified Animals: Strategies and applications
Masters UAM of Molecular Biomedicine
9-30 October 2017 15:00-18:00 h
School of Medicine, UAM, Campus “La Paz”, Seminar-room 12
Coordinators:
UU

Laura Formentini (UAM-CBMSO)
Tel. 911964648
lformentini@cbm.csic.es
Miguel Manzanares (CNIC-ISCIII)
Tel. 914531200
mmanzanares@cnic.es
HU

U

Lluís Montoliu (CNB-CSIC)
Tel. 915854844
montoliu@cnb.csic.es
HUU

Sagrario Ortega (CNIO-ISCIII)
Tel. 917328000
sortega@cnio.esHUU______________

Invited faculties:
Juan Bernal
CNIC
Juan Ramón Martínez Morales
CABD, Sevilla
Marcos Malumbres
CNIO
Francisco J. Martínez Mojica
Universidad de Alicante
Latifa Bakiri
CNIO, Genes, development and disease group

All lectures will be delivered in English

BMM11 module, Master UAM Course 2017-2018 (10th edition)1

BMM11 PROGRAM – MASTER UAM COURSE 2017/2018______________________________________________________________________FIRST WEEK
Monday, 9 OctoberIntroduction to BMM11 module: evaluation criteria (30 min) – coordinators
Laura Formentini, Miguel Manzanares, Lluís Montoliu, Sagrario Ortega
Use of mice in biomedicine: history, genetics (60 min)Miguel Manzanares, CNIC
Mouse biology and developmental biology: highlights and main topics (90 min)Miguel Manzanares, CNIC
Tuesday, 10 OctoberTransgenic animals: highlights and main topics (90 min)Lluís Montoliu, CNB-CSIC
Embryonic stem cells and other pluripotent cells: highlights and main topics (90 min)Sagrario Ortega, CNIO
Wednesday, 11 October
Examples of transgenic animals I (90 min)Lluís Montoliu, CNB-CSIC
Examples of transgenic animals II (90 min)Lluís Montoliu, CNB-CSIC
Thursday, 12 October
National FestFriday, 13 October
Submission of abstracts for student’s research projects (moodle) and briefpresentation (180 min) – max. 10 min / group, including discussion
Laura Formentini, Miguel Manzanares, Lluís Montoliu, Sagrario Ortega

BMM11 module, Master UAM Course 2017-2018 (10th edition)2

BMM11 PROGRAM – MASTER UAM COURSE 2017/2018______________________________________________________________________SECOND WEEK
Monday, 16 October
Examples of ES and other pluripotent cells I (90 min)Sagrario Ortega, CNIO
Invited seminar: Mouse models in cell cycle research (90 min)Marcos Malumbres, CNIO
Tuesday, 17 October
Examples of ES and other pluripotent cells III (90 min)Sagrario Ortega, CNIO
Examples of gene regulatory analysis in the mouse I (90 min)Miguel Manzanares, CNIC
Wednesday, 18 October
Examples of gene regulatory analysis in the mouse II (90 min)Miguel Manzanares, CNIC
Examples of gene regulatory analysis in the mouse III (90 min)Miguel Manzanares, CNIC
Thursday, 19 October Aula/Room 0
Host: Lluís Montoliu
Invited seminar: The origin of the CRISPR-Cas systems (90 min)Francisco J. Martínez Mojica, Universidad de Alicante
Examples of genome editing (90 min)Lluís Montoliu, CNB-CSIC
Friday, 20 October
UAM School of Medicine’s Annual FestBMM11 module, Master UAM Course 2017-2018 (10th edition)

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BMM11 PROGRAM – MASTER UAM COURSE 2017/2018______________________________________________________________________THIRD WEEK
Monday, 23 October
Examples of functional genomics of the mitochondria I (90 min)Laura Formentini, UAM-CBMSOExamples of functional genomics of the mitochondria II (90 min)Laura Formentini, UAM-CBMSO
Tuesday, 24 October
Host: Laura Formentini
Invited seminar: Using zebrafish and medaka as animal models (90 min)Juan Ramón Martínez Morales, CABD, Sevilla
Invited seminar: Advances in animal transgenesis: new tools for a new era (90 min)Juan Bernal, CNIC
Wednesday, 25 October
Host: Laura Formentini, Sagrario Ortega
Invited seminar: In vivo models to study glioblastoma (90 min)
Massimo Squatrito, CNIO
Invited seminar: Mouse models to study liver cancer (90 min)
Latifa Bakiri, Genes, development and disease group (CNIO)
Thursday, 26 OctoberStudent’s presentation of their research projects I (180 min)(max. 20 min/group: 15 min presentation and 5 min discussion)
Laura Formentini, Sagrario Ortega
Friday, 27 OctoberStudent’s presentation of their research projects II (180 min)(max. 20 min/group: 15 min presentation and 5 min discussion)
Laura Formentini, Lluís Montoliu, Sagrario Ortega______________________________________________________________________FOURTH WEEK
Monday, 30 October
Final Exam with correction and discussion afterwards (90 min)Submission of research project (moodle)
Laura Formentini, Miguel Manzanares, Lluís Montoliu, Sagrario Ortega

BMM11 module, Master UAM Course 2017-2018 (10th edition)

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BMM11 PROGRAM – MASTER UAM COURSE 2017-2018
BMM11 Module, Evaluation Criteria

Participation (4 points, 40%): Students, in groups of three (3) persons max., will gather
and select a relevant biomedical question of their choice to be addressed through ascientific research project requiring the use of genetically modified animal and/or cellularmodels. Students will submit a brief summary (abstract, 1 page max) of their selected
research project by the end of the first week, to be uploaded through the moodle
application. They will also introduce the chosen approach and a brief outline of theirresearch project (max. 10 min, including discussion, Powerpoint presentation optional) atthe end of the first week. Finally, they will present and develop their research project on
the third week (max. 20 min/group: 15 min presentation and 5 min discussion).
Written report (3 points, 30%): Students, distributed according to the same groups of 3
persons max., as indicated before, will gather and cooperatively write the scientificresearch project of their choice, requiring the use of genetically modified animal and/or
cellular models (4 pages max, in English). This written report will have to be ready anduploaded at the “UAM Biociencias-Master” web server through the moodle application, by10 November.
Exam (3 points, 30%): The exam (60 min) will be prepared as a test of 30 questions with
5 possible answers (only 1 will be correct). Wrong answers will not decrease the final
mark. The correct answer for each and every question will be provided and discussed at
the end of the exam (30 min).

BMM11 module, Master UAM Course 2017-2018 (10th edition)5