The 15th Annual Meeting of JSIT
September 11-12, 2008, Tokyo, Japan
President: Jun-ichi SAWADA National Institute of Health Sciences, Japan
Keynote Lecture
Genetic polymorphisms andmyelotoxicity of anti-cancer drugs

Jun-ichi Sawada

National Institute ofHealth Sciences

Keiko Nohara

National Institue forf
Environmental Studies

Stephen B. Pruett

College of Veterinary
Medicine, Mississippi
State University

Master’s Lecture
Immunotoxicogenomics ofenvironmental chemicals
Invited Plenary Lecture
Immunotoxicology of innate immunity
Symposium <1>
Immunotoxicity of nanoparticles

Organizer
Takemi Otsuki
Seishiro Hirano

Hidekazu FujimakiHirohisa Takano

Immunotoxicogenomics ofenvironmental chemicals
The importance of characterization for
nanoparticles and its pulmonary effects
in rats.

Akihiko Hirose

Department of Hygiene,
Kawasaki Medical School
National Institue forf
Environmental Studies
Research Center for
Environmental Risk,
National Institute forEnvironmental Studies
Environmental Health
Sciences Division,
National Institute forEnvironmental Studies
National Institute of
Health Sciences

Akira Ogami(1),(1)Institute of Industrial
Yasuo
Ecological Sciences,
Morimoto(1),Takako University of
Oyabu(1), Toshihiko Occupational andMyojo(1), Masahiro Environmental Health,
Murakami(1), Motoi (2)Graduate School ofTodoroki(1),Engineering, Hiroshima
MakotoUniversity, (3)NationalYamamoto(1),Institute of Advanced
MasamiIndustrial Science andHirohashi(1),TechnologySayumi
Yamasaki(1),ManabuShimada(2),Shigehisa
Endoh(3), KunioUchida(3), Junko

Nakanishi(3),Isamu Tanaka(1)Synergistic effects ofnanoparticles/materials on pathologicalconditions

Ken-ichiro Inoue,

Environmental Health

Rie Yanagisawa,

Sciences Division,

Eiko Koike, Hirohisa National Institute for
TakanoEnvironmental Studies

Kenji Sugibayasi

Josei University

Safety concerns of nanomaterials toskin: Safety and skin penetration ofnanomaterials.
Symposium <2>
Gut-associated lymphoid tissues andtheir regulations

Organizer
Reiko Teshima

National Institute ofHealth Sciences

Yukiko Kanazawa

Hatano ResearchInstitute, Food and Drug
Safety Center

Regulation of gut immunity by retinoids

Makoto Iwata(1),Aya Yokota(1),HajimeTakeuchi(1),Yoshiharu
Ohoka(1), Si-Young
Song(2)(1)Biodefense Research,
Faculty of
Pharmaceutical Sciencesat Kagawa Campus,
Tokushima Bunri
University, (2)Institute ofNeuroscience,
Tokushima Bunri
University

Intestinal immunity-mediated allergy Establishment of murine food allergy
model-Tomoko Shindo(1),YukikoKanazawa(1),Kohichi Kojima(1),Reiko Teshima(2,1)(1)Hatano ResearchInstitute, Food and Drug
Safety Center,(2)National Institute ofHealth Sciences

Immunomodulation by probiotic
lactobacilli through regulating functionsof macrophages

Kan Shida

Yakult Central Institutefor MicrobiologicalResearch

Mucosal immune dysfunction by thetrichothecene mycotoxins

James J. Pestka

Center for Integrative
Toxicology, Michigan
State University

WorkshopSecondary immunomodulatory effects
and allergenicity of pharmaceuticals

Regulation of allergic immune response
by PPAR agonists
The role of dopamine as an immune
modulator

Organizer
Nsohosa TsutsuiMitsubishi Tanabe
Pharma Corporetion

Shigeru Hisada

ASKA Phrmaceutical Co.,Ltd.

Eiji Maki

BiosafetyResearchCenter,Foods, Drugs andPesticides

Shigeharu Ueki

Akita University Schoolof Medicine

Kazuhisa Nakano

University ofOccupational andEnvironmental Health(1)Japanese Center for
the Validation of
Alternative Methods
Hajime Kojima(1),Inter-laboratory validation studies on

Kenji Idehara(2),LLNA-DA and LLNA-BrdU

Masahiro
Takeyoshi(3,1)(JaCVAM), Div. of
Pharmacology, National
Institute of Health
Sciences (NIHS),(2)Daicel ChemicalIndustries, Ltd,
(3)Chemical Evaluation
and Research Institute

Validation of non-RI methods -Data

Takashi Omori(1),analysis-

Takashi Sozu(2)Briefing of ICCVAM LLNA peer review
meeting

Takahiko Yoshida(1)Kyoto University
School of Public Health,(2)Osaka University
Asahikawa MedicalCollege

Oral Presentations
Qing Li, Maiko
Chlorpyrifos induces apoptosis in human
Kobayashi,
T cells
Tomoyuki Kawada

Department of Hygieneand Public Health,Nippon Medical School

The effects of tributyltin on thymiclymphocyte populations in F1 rats after
subacute administration

Masashi Tsunoda(1), Masayoshi(1)Preventive Med. andTsuji(2), Ying
Public Health, Kitasato
Zhang(1), Sachiko
Univ. School of Med,Kimura(1), Yuichiro(2)Mejiro Univ.,
Kudo(1), Hiroshi(3)Kitasato Univ. SchoolKatagiri(3), Mikaof Allied Health Sci. ,Wakasa(4), Tomoko(4)Aoyama Gakuin Univ.
Tashiro(4), Yoshiko, (5)National Instit.
Sugita-Konishi(5),Health Sci.
Yoshiharu
Aizawa(1)Effect of toluene exposure and BCG
stimulation in the infant mice on
development of Th1/Th2 balance

Shoji Yamamoto,
Tin-Tin Win-Shwe,
Hidekazu Fujimaki

Research Center for
Environmental Risk,
National Institute forEnvironmental Studies

Tomonori Hayashi,
Radiation effects on aging-associatedelevation of inflammatory markers
among atomic-bomb survivors

Yoichiro Kusunoki,
Yukari Morishita,
Hiroko Nagamura,
Mayumi Maki,
Yoshiko Kubo,
Kengo Yoshida, Kei
Nakachi,

The Department ofRadiobiology/Molecular
Epidemiology, Radiation
Effects ResearchFoundation

Investigation of evaluation methods forinnate immune responses to viral

Tomoaki Inoue(1),Chiyomi Kubo(1),(1)Safety Assessment
Dept., Fuji Gotemba

component dsRNA in monkeys

Takayuki
Research Labs., Chugai
Sakurai(1), Akifumi Pharmaceutical Co., Ltd.,
Shioda(1), Marie
Hayakawa(1),(2)Chugai ResearchInstitute for Medical

Yukihito Miura(2),Tatsuya Ito(2),Science, Inc.

KazutoWatanabe(1)Validity evaluation of human cell line
activation test for differentiation of skinsensitizers from irritant chemicals inYong Heo

Catholic University ofDeagu, Korea

vitro
Rie Yanagisawa(1), (1)Environmental Health
Hirohisa Takano(1), Sciences Division,
Effects of latex nanoparticles on atopic
dermatitis-like skin lesions in NC/Ngamice.

Ken-ichiroInoue(1), EikoNational Institute forEnvironmental Studies,Koike(1), KaoriSadakane(2),Takamichi(2)Department of HealthSciences, Oita University
of Nursing and HealthIchinose(2)Sciences

Yasumitsu
Nishimura(1),Megumi Maeda(1),Naoko Kumagai(1), (1)Department of

Peripheral blood NK cells in patients withShuko
mesothelioma and NK cells in PBMCs
Murakami(1),exposed to asbestos show a common
Hiroaki Hayashi(1),decrease in expression of NKp46
Ying Chen(1),TakumiHygiene, Kawasaki
Medical School,(2)Okayama Rosai
Hospital

Kishimoto(2),Takemi Otsuki(1)Megumi Maeda(1),Yasumitsu
Nishimura(1),Shuko(1)Department ofAnalysis of chemokine receptor CXCR3
expression in human CD4+ T cells

Murakami(1),Hygiene, Kawasaki
Naoko Kumagai(1), Medical School,

exposed to asbestos

Hiroaki Hayashi(1),Ying Chen(1),(2)Okayama Rosai
Hospital

Takumi
Kishimoto(2),Takemi Otsuki(1)Associations between HLA alleles andYoshiro Saito(1,2),

Stevens-Johnson syndrome and toxic
epidermal necrolysis in Japanese

Masahiro
Health Sciences, (2)JSARTohkin(1,2), Kouichi Research Grouppatients.

Kurose(1,2), Junichi Sawada(1),Ryuichi
Hasegawa(1,2),
Chie Sotozono(2),Shigeru
Kinoshita(2),YukitoshiTakahashi(2),Hirokazu Furuya(2),Masaaki
Muramatsu(2),KayokoMatsunaga(2),Michiko Aihara(2),Zenro Ikezawa(2),(1)National Institute ofNahokoKaniwa(1,2)
Hiroaki Hayashi(1),Megumi Maeda(1),ShukoSerum levels of soluble IL-2 receptor as

Murakami(1),(1)Department of
Naoko Kumagai(1), Hygiene, Kawasaki

an immunological disorder in silicosis
patients.

Ying Chen(1),Yasumitsu

Medical School,(2)Kusaka Hospital,

Nishimura(1),Masayasu

Bizen

Kusaka(2), Takemi
Otsuki(1)YoshihiroTakahashi(1),An poliovirus entry in rhesus macaques

Atsunobu(1)Shin Nippon
Muneoka(1), Shogo
Biomedical Laboratories,
Misumi(2), MitsuakiLtd., (2)Department of
Masuyama (1,2),
Pharmaceutical
Yasuharu
Biochemistry, Graduate
Otsubo(1), Takahiro
School of Medical andNakamura(1),Pharmaceutical Sciences,
Shozo Shoji(2),Kumamoto University
Hiroyuki Izumi (1),TakayukiSukamoto(1)Nobuaki(1)Department ofPharmacology, Kobe

Pharmaceutical
Mizutani(1), Takeshi
University,Nabe(2), Masanori(2)Department of
Polycyclic aromatic hydrocarbons
Fujii(2), Shin
Pharmacology, Kyoto
aggravate antigen-induced nasal
Yoshino(1),Pharmaceutical
blockage in experimental allergic rhinitis Teruhisa
University,
Hirayama(3),(3)Department of Public
Shigemakatsu
health, KyotoKohno(2)PharmaceuticalUniversity(1)Tokushima Bunri
University, Faculty of

Effects of exposure to low-dose arsenite
on degranulation of mast cells

Yuri Shimizu(1),Yumiko Nishii(2),Nobuyuki

Pharmaceutical Sciences,
Laboratory of Molecular
Nutrition and Toxicology,

Fukuishi(2),Masaaki Akagi(2),(2)Tokushima Bunri
University, Faculty ofSeiichiro Himeno(1) Pharmaceutical Sciences,
Laboratory of
Pharmacology
Di-(2-ethylhexyl) phthalate affect theactivation of immune cells from atopicprone mice in vitro

Eiko Koike, Hirohisa Environmental Health
Takano, Ken-Ichiro Sciences Division,Inoue, Rie
National Institute for
Yanagisawa

Environmental Studies

Poster Discussion
Carotenoid intake inhibits the oral
sensitization and development of food

Hiroshi Akiyama(1), (1)Division of Novel
Yuji Sato(1), Hideki Foods andallergies

Matsuoka(1), Rika

Immnochemistry,

Nakamura(1),RyosukeNational Institute ofHealth Sciences,,Nakamura(1),(2)Research Institute,
Shingo Ishikawa(2), Kagome Co., LTD.,
Takahiro(3)Department ofInakuma(2),Mamoru

Applied BiologicalChemistry, TheTotsuka(3), ReikoTeshima(1)University of Tokyo

Hideki Harada,
Multicolor flow cytometry for
differentiation analysis of monkey
peripheral T cells

Makoto Tsumemi,
Hideki Tokudome,
Yasuko Yakabe,
Takayuki Okamura,
Yasuyuki Ohnishi

Safety Assessment
Division I, Kashima
Laboratory, Mitsubishi
Chemical Safety InstituteLtd

Naoko Kumagai,
Yasumitsu
Effect of exposure to asbestos on theNishimura, Megumi

lytic function of human cytotoxic T
lymphocytes

Maeda, Shuko
Murakami, Hiroaki

Department of Hygiene,
Kawasaki Medical SchoolHayashi, Yin Chen,Takemi Otsuki
Ying Chen, Megumi
Comparison of cytokine secretion
between a human T cell line and asubline continuously exposed tochrysotile asbestos

Maeda, Shuko
Murakami, Naoko

Department of Hygiene,
Kumagai, Hiroaki
Kawasaki Medical School
Hayashi, Yasumitsu
Nishimura, Takemi
OtsukiTakayuki Okamura,
Hideki Tokudome,

Validation of the peripheral blood
lymphocyte subset test in beagle dogs

Yasuko Yakabe,
MakotoTsunemi,
Hideki Harada,
Yasuyuki Ohnishi

Safety Assessment
Division I, Kashima
Laboratory, Mitsubishi
Chemical Safety InstituteLtd.
(1)Research Center for

Tin-Tin Win-Environmental Risk,

Strain difference of extracellular aminoacid neurotransmitter levels in theShwe(1), Dai
Mitsushima(2),National Institute forEnvironmental Studies,hippocampus of MHC-congenic mice

Shoji Yamamoto(1), (2)Department of

exposed to toluene

HidekazuFujimaki(1)Physiology, Yokohama
City University Graduate
School of Medicine

Tomoki Fukuyama,
Yukari Tajima,
Identifying the low dose chemical-

Hideo Ueno, Koichi

induced respiratory allergic response inHayashi, Yasufumi

miceShuto, Takanori
Harada, Tadashi

Toxicology Division, TheInstitute ofEnvironmental
Toxicology

KosakaThe effect of Methoxychlor (MXC) on the Koichi Hayashi,

The Institute of

immune response to SRBC-antigen inTomoki Fukuyama,

Environmental

infant rats.

Yukari Tajima,

Toxicology

Hideo Ueda,

Yasufumi Syutoh,
Takanori Harada,
Tadashi Kosaka
Ryoji Hirota(1),Junko Yokota(2),Masahide
Onogawa(2,3),
MitsuhikoMiyamura(2),Kunihiro
Akimaru(1),Preventive effect of bronchial asthma by Hiroyuki
administration of Japanese loquatNakamura(4),(1)Dept. Environmental
Medicine, Kochi Medical
School, (2)Dept.
Pharmacy, Kochi Medical
School Hospital, (3)Dept.
Biomedical Science,
Kochi Medical Graduate
School, (4)Dept.
Environmental andPreventive Medicine,
Kanazawa University
Graduate School of(Eriobotrya japonica) seeds extract inHiroshi

mice.

Iwamoto(5), Akihito

Optimization and validation of in vitro

Seiji Shibata, Mitui

Safety Researchneutrophil phagocytosis assay using rat

Isobe, Shigeru

Department, ASKA

whole blood

HisadaPharmaceutical Co., Ltd

The enhancement of T cell proliferation
caused by trichloroethylene ingestion
from drinking water

Medical Science,
Yokoyama(5),(5)Dept. HematologyHiroyuki Tanaka(6),and Respiratory
Naoki Inagaki(6),Medicine, Kochi
Hiroichi Nagai(6),University, (6)Laboratory
Narufumiof Pharmacology, Dept.
Suganuma(1),Bioactive Molecules, GifuYutaka
Pharmaceutical
Nishioka(2,3)
University

Ryo Kobayashi,
Syosaku Watanabe, Gifu Pharmaceutical
Tsuyoshi Nakanishi, University, Gifu, Japan
Hisamitsu Nagase
Yasuhiro Tanaka,
Yoshihiro
Takahashi, Kaori
Kumano, Yasuharu

Validation study of LLNA (Local Lymph
Node Assay) with BrdU assay using CBAstrain miceOtsubo, Nozomi
Matsuo, Yusuke

Drug Safety ResearchLaboratories, ShinYamashita, Shinji

Nippon Biomedical

Utsunomiya,

Laboratories, Ltd.

Takayuki Ichii,,
Takahiro Nakamura,
Hiroyuki Izumi,
Takayuki Sukamoto
Differences in gene expression profilesof the lesions with TNBS- and DSS-

Yasuhiro
Matsumoto, Motoko

Safety ResearchDepartment, ASKA

induced colitis

Fukui, Seiichi Araki,
Pharmaceutical Co., Ltd.
Shigeru Hisada

Effect of nanomaterials against innate

Tanabe Aya(1),(1)Dept. Biotechnology

immunity

Yoshioka
Yasuo(1,2),

and Therapeutics
Graduate School ofMorishige

Pharmaceutical Sciences,Tomohiro(1),Tsunoda Shin-Osaka University, (2)The
center for Advancedichi(2,4), Tsutsumi

Medical Engineering andYasuo(2,3,4), Mukai Informatics, OsakaYohei(1), OkadaNaoki(1),University, (3)Dept.
Toxicology, Graduate

Nakagawa

School of Pharmaceutical

Shinnsaku(1,2)

Sciences, Osaka
University, (4)National
Institute of Biomedical
Innovation (NiBio)

M.H.M van Tuyl,A.H.B.M van
Alternative endpoints in the LLNA in

Huygevoort, R.P.L

order to reduce false positive results

van Swelm, H.H.
Emmen, M.

NOTOX B.V. ‘sHertogenbosch, theNetherlands

Stitzinger
Kei-ichiSugiyama(1),The studies for the effect ofdeoxynivalenol on Toll-like receptor
signaling pathways

Masashi Muroi(1),(1)National Institute ofYuji Minai(2), Kenichi Tanamoto(1),Health Sciences,(2)Faculty of Agriculture,

Minoru Haga(2),Tamagawa University

Yoshiko SugitaKonishi(1)Myelotoxicity of indium chloride chromosomal aberration-Yuichi Miyakoshi,

Dept. public health andYuji Suzuki,
Hiroyuki

environmental medicine,
The Jikei University

Yanagisawa

School of Medicine

Luncheon Seminar <1>
Immunological Assessment and the Useof Biomarkers in Translational Medicine

Charles River
LawrenceJacobLaboratories, Edinburgh,
UK

Luncheon Seminar <2>
Nonclinicalstrategiestomitigatetheriskforfirstinmanstudieswithimmunomodulatorydrugs

MarkWing

Huntingdon LifeSciences, Huntingdon,
England