The 9th Annual Meeting of JSIT
2002.9.19-20.
GranShip (Shizuoka Convention & Art Center) (Shizuoka)
President: Yasuaki Arakawa (The University of Shizuoka)
Sepcial LectureⅠ
The mechanism for mucosal
injuries induced by invasive
Hiroshi Nagura
antigens through the mucosal
barrier system.

Division of Pathology, SendaiShakaihoken Hospital, andTohoku University Graduate
School of Medical Science

Sepcial LectureⅡ
Dynamism of mucosal
immunity for the control of
infectious disease.

Division of Mucosal
Hiroshi Kiyono

Immunology, The Institute ofMedical Science, The Universiyof Tokyo, Tokyo, Japan

President's Lecture
Morbid aging of thymus
immunology by environmental Yasuaki Arakawa
factor.

Department of Hygiene &Preventive Medicine, Faculty ofHealth Sciences, The
University of Shizuoka

Educational LectureⅠ

なし

Graduate School of Agriculturaland Life Sciences, Faculty ofShuichi Kaminogawa
Agriculture, University ofTokyo, Tokyo, Japan

Educational LectureⅡ
Risk assessment ofenvironmental trace chemicals
based on animal and humanOsamu Wada
immunological studies:
Especially in regards todioxins.

Dept. Hygiene & PreventiveMed., Saitama Medical School

Symposium

Immunotoxicity of arseniccompounds.

Teruaki Sakurai,
Kitao Fujiwara

Laboratory of Environmental
Chemistry, School of Life
Science, Tokyo University of
Pharmacy and Life Science,Tokyo, Japan

Immunotoxicity of dioxin.

Keiko Nohara (1,2),
Chiharu Tohyama(1,2)(1)Environm. Health Sci. Div.,
Natl. Inst. Environm. Studies,
Tsukuba, Japan, (2)CREST,JST, Kawaguchi, Japan

Individual difference ofsensitivity to smoking andlung damage in pulmonary
immunity

Tomoko Betsuyaku(1), Michie Taniya(1), Kei Nagai (1),Yasuyuki Nasuhara(1), Yoshio Kuroki

The First Department ofInternal Medicine, Hokkaido
University School of Medicine,
Sapporo, Japan(2), Masaharu
Nishimura (1)Immunotoxicity in diesel

Hidekazu Fujimaki,

exhaust inhalation.

Yoshika Kurokawa

National Institute forEnvironmental Studies,
Tsukuba, JapanWorkshop
International harmonization of
immunotoxiology study
guidelines of synthetic

Developmental Research
Kazuichi Nakamura

pharmaceuticals.

Laboratories, Shionogi & Co.,
Ltd.
Division of Biochemistry andDraft guidance for
immunotoxicity testing.

Jun-ich Sawada

Immunochemistry, National
Institute of Health Sciences,
Tokyo, Japan

Assortment of biotechnologybased drugs and points ofremember on
immunotoxicologicalassessment

Takahiro NakazawaImmunotoxicological issues ofTakayoshi Kobayashi
biopharmaceuticals.

Eli Lilly Japan K.K.

Amgen Limited, PreclinicalDevelopment, Tokyo, JapanGeneral Oral Presentation
Effects of ATRA on humanTakemi Otsuki, Akiko
myeloma cells and the role ofDept, Hyg., Kawasaki Med.
Tomokuni, Fuminori
IL-10 in ATRA-induced growthSch. Kurashiki, Japan.
Hyodohalteration.
(1)Hatano Research Institute,Food and Drug Safety Center,
Kanagawa, Japan, (2)School of
Pharmaceutical Sciences,
Showa University, Tokyo,Japan, (3)Shiseido ResearchCenter, Kanagawa, Japan,(4)Institute of MedicalSciences, Tokyo University,Tokyo, Japan

Role of TNF-alfa in allergic
contact dermatitis.

Yukiko Kanazawa(1,2), Takiko Oguro(2), Masato Hatao(3), Reiko Horai (4),Masahide Asano (4),Yoichiro Iwakura (4),Hiroshi Ono (1),Takemi Yoshida (2)Rat strain comparison of
immunosuppression bycyclophosphamide on plaqueforming cell assay.

Ryota Kawai, Tetsuo
Aida, Motoko Ajioka, Medicinal Safety Research
Masae Yagi, Tsutomu Laboratories, Sankyo Co., Ltd
KimuraTakahiko Yoshida(1)Department of Hygiene,(1), Toshihiro Itoh
Asahikawa Medical College,(1), Yoshihiko Nakagi
Asahikawa, Japan, (2)FacultyEvaluation of the immune(1), Motoyasu
of Pharmacological Science,parameters for assessment of Ohsawa (2),Teikyo University, Tokyo,
environmental risk on human Fuminori Otsuka (2),Japan, (3)National Institute ofhealth. -Field research on 3
Kazuko Takahashi
Health Sciences, Tokyo, Japan,
years old children.2nd report- (2), Reiko Teshima(4)Hatano Research Institute,(3), Jun-ichi Sawada
Food & Drug Safety Center,(3), Kohichi Kojima
Hatano, Japan(4)
NK cell activity assay using
calcein acetoxymethyl ester.

Nagata M., KanasakiK., Hino M.,

Developmental ResearchLaboratories, Shionogi & Co.,

Immunotoxic properties ofNakamura K.

Ltd.

M. Ohsawa (1), K.

(1)Fac. Pharmaceut. Sci.,

chemicals evaluated by use of Takahashi (1), H.

Teikyo Univ., (2) Natl. Inst.

in vitro antibody production

Tokunaga (2), H.

Health Sci., (3)Grad. Sch.

system.

Utsumi (3)Pharmaceut. Sci., Kyushu Univ.

Pathologic changes in local
and systemic immune organs
in the adjuvant-arthritic rats
treated with a p38 MAPK
inhibitor for four weeks.

Shigeru Hisada (1),Jun Sato (2), Hajime
Asano (2), Yasuhiro
Matsumoto (2),Hideki Morimoto (1),Takashi Mikami (1)(1)Safety Research
Department, Teikoku Hormone
Mfg. Co., Ltd., Kawasaki,Japan, (2)Pharmaceutical
Research Deparatment,
Teikoku Hormone Mfg. Co.,
Ltd.
(1)Division of Environmental

Jianhong Zhao (1,2),

Immunology and Toxicology,

Department of Health Science,
LPS mediated acute
Hiroko Otsuka (1),Jichi Medical School, Kawachiinflammation is suppressed by Atsumi Kikuchi (1,2),
Gun, Japan, (2)CREST, Japansoy isoflavones in rat liver.
Yukitomo Arao (1,2),
Science and Technology
Fjio Kayama (1,2)
Corporation, Kawaguchi City,Saitama, Japan(1)Department of Hygiene,
Yoshihiko Nakagi (1),Immunotoxicological effects ofAsahikawa Medical College,
Toshihiro Itoh (1),formaldehyde via digestive
Asahikawa, Japan, (2)Kitasato
Takahiko Yoshidatract.
Institute Hospital, Tokyo,(1), Kou Sakabe (2)Japan(1)Division of Microbiology,
Effect of lactational exposure
National Institute of HealthYoshiko Konishi (1),to 2,3,7,8-TetrachlorodibenzoSciences, Tokyo, Japan,Kazuo Kobayashi (1),p-dioxin on the susceptibility(2)Department of Veterinary,
Yoshihiko Suzuki (2)to Listeria infection.
Azabu University, Kanagawa,JapanA low dose effect ofxenobiotics on thymus
microenvironment, withK. Sakabe (1,2), T.
Yoshida (3), F.

(1)The Kitasato Institute,(2)Graduate School of MedicalSciences, Kitasato University,

special reference to DBP andDEHP.

Kayama(4)(3)Asahikawa Medical College,(4)Jichi Medical School

Effects of environmental

Hagio Nihei, Youhei

Department of Veterinary

hormones on cell-mediatedimmunity in ginbuna crusian

Rintsu, Tadaaki
Moritomo, Teruyuki

medicine, College of
Bioresource sciences, Nihoncarp.

Nakanishi

UniversityKazuo Takahashi,
Yoshihiro Takeshita,
Tributyltin-inducedChiaki Iwamura,immunological profile in mice.
Yuuko Ikezawa,Zenro Ikezawa

The in vitro effects oftributyltin (TBT) chloride on
cytokine mRNA expression inmurine macrophage cells.

Department of Dermatology,
Yokohama city university,
Yokohama, Japan(1)Department of Public
Health, School of Medicine,

Masashi Tsunoda
Fukushima Medical University,(1), Nobuhiro Konno Fukushima, Japan,(1), Ken Nakano (2)(2)Fukushima Institute of
Public Health, Fukushima,
Japan

Genral Poster Presentation

Immuno-toxic effects on thethymic lymphocytes inducedby the neonatal treatment ofDiethylstillbestrol (DES) in rat
pups.

Koichi Hayashi,
Tadashi Kosaka,
Yukiko Takeuchi,
Takanori Harada

Institute of environmental
toxicology

Immunotoxicological approachto oral administration of live
Toshihide Kobayashi,
lactobacilli and bifidobacteria.
-The development ofKayoko Komatsu,
Yakult Central Institute for
Ikuo Kato, Masaharu Microbiological Research

immunological functions inneonate mice-Onoue

Gene expression changes inRyosuke Nakamura(1), Junichi Ishida(1)Division of Biochemistry(2), Shogo Ozawa(2), Haruyo Okunukiand Immunochemistry,
National Institute of HealthRBL-2H3 cells stimulated with(1), Yoshiro Saito
antigen and DTBHQ.
(1), Reiko Teshima

Sciences, (2)Division ofPharmacology, National(1), Jun-ichi Sawada Institute of Health Sciences(1)

Allergic reactions to a protein
antigen in MES rats.

Yasuhide Kouchi (1),(1)Drug Safety Research Lab.,
Norifumi Matsushita
Taiho Pharmaceutical Co. Ltd,(1), Shuji Hayashi(2)Institute of Experimental(1), Rumi KawabataAnimals, Shinshu University(1), Kiyoshi
School of Medicine
Matsumoto (2)Detection of respiratory

Hideo Ueda (1),Tadashi Kosaka (2),sensitization potential oftrimellitic anhydride (TMA) in

Koichi Hayashi (2),
Yuko Chiba (2),a challenge phase-added
mouse Ig E test.

Nobuaki Nakashima(2), Koichi Ebino (1),(1)Toxicology Division Ⅰ,(2)Toxicology Division Ⅱ, The
Institute of Environmental
Toxicology, Ibaraki, Japan

Shoji Teramoto (1)The effects of 2,3,7,8tetrachlorodibenzo- p-dioxin(TCDD) on long-lived
antibody-forming cells inhumoral immunity.

Kaoru Inouye (1,2),
Tomohiro Ito (1,3),
Hidekazu Fujimaki(1,3), Chiharu
Tohyama (1,3),
Keiko Nohara (1,3)(1)National Institute forEnvironmental Studies,
Tsukuba, Japan, (2)Domestic
Research Fellow, Japan Society
for the Promotion of Science,
Tokyo, Japan, (3)CREST, JST,Kawaguchi, Japan

Yoshihiro Ikumi (1),Kuniaki Takagi (1),Characterization andHitoshi Harada (1),
Akira Ikari (1),distribution of
lipopolysaccharide in Deep

Yoshitsugu Hagiwara Shizuoka, Japan, (2)Shizuoka(2), Atsushi
Prefectural Fisheries

Sea Water.

Shimamoto (2),Yasumasa Igarashi(2), Suguru Wada

(1)University of Shizuoka,

Experimental Station(2)
Suppressive effects of dioxin
on T cell activation andTomohiro Ito (1,2),
Kaoru Inouye (1,3),(1)Environmental Health
Sciences Division, National

differentiation.

Hidekazu Fujimaki(1,2), Chiharu

Institute for EnvironmentalStudies, Tsukuba, Japan,Tohyama (1,2),
Keiko Nohara (1,2)(2)CREST, JST, Kawaguchi,Japan, (3) Domestic Research
Fellow, JSPS, Tokyo, Japan

In vitro digestibility study as
one of the prediction studies
of food allergenicity.

Reiko Teshima,
Kayoko Takagi,
Haruyo Okunuki,

Division of Biochemistry andImmunochemistry, National

Ryosuke Nakamura,
Akiko Hachisuka,

Institute of Health Sciences,Tokyo, Japan

Jun-ichi SawadaLuncheon seminar Ⅰ

Regulatory immunotoxicology
and immunopharmacology in
non-clinical drug development

Mark G Wing

Head of Experimental Biology
and Senior Immunologist,
Biosciences Division,
Huntingdon Life Sciences, Ltd.,
Huntingdon, Cambridgeshire,
UK

Luncheon seminar Ⅱ
Routine immunotoxicity
testing ofpharmaceuticals:lessons from

RCC, Cytotest Cell ResearchGmbH, In den
Leppsteinswiesen 19, D-64380

the first two years

Rosdorf, Germany