Classification of Infectious Disease Law in Japan
Type 1(7)Viral Hemorrhagic Fever

EVD
Lassa Fever
CCHF
Marburg disease
South American
Hemorrhagic Fevers

PlagueSmallpox

Type 2(7)Tuberculosis
MERS
SARS
Avian flu
(H5N1/H7N9)
Polio
Diphtheria

Type 3(5)CholeraTyphoid fever
Paratyphoid fever

Dysentery
EHEC infection

Type 4(44)DengueZika
Chikungunya
Yellow Fever
Hepatitis A
Legionellosis
SFTS
Rabiesetc…

Classification of Medical Centerin Infectious Disease Law in JapanNew Infectious
Diseases

4

Type I Infectious
Diseases

Type II Infectious
Diseases

OthersMedical institutions designated for specific infectious diseases

49

Medical institutions
designated for type I infectious diseases

340

Medical institutions
designated for type II infectious diseases

not designatedViral Hemorrhagic FeverViral Hemorrhagic Fever•Classified as type 1 infectious diseases in law•

Ebola virus disease(EVD), Lassa Fever, Crimean-Congo
haemorrhagic fever(CCHF), Marburg disease, SouthAmerican Hemorrhagic Fevers•

Probable cases should be admitted to “Specified /Category 1 infectious diseases hospital”

Medical institutions designated for specific infectious diseases

4 Hospitals locatednear international airports
Rinku Medical Center(Kansai Airport: KIX)
Narita Red Cross Hospital(Narita Airport: NRT)
NCGM
(Haneda Airport: HND)
Tokoname City Hospital(Centrair Airport: NGO)

Medical institutions designated for type I infectious diseases

49 Hospitals locatedalmost every prefecturesnagement protocol for people with a travel history to EVD endemic c

NCGMquarantine

NIID

Euro Surveill. 2015;20(44).

Case definition of probable caseduring EVD outbreak•1) fever >38 °C or clinical symptoms of EVD AND•2) history of contact with body fluids through EVD
patients OR history of contact with bats and primatesin endemic countries within 21 days.

4 suspected EVD cases
Cases

datecountries

ebola
PCR

duration ofisolation

final diagnosis

40s M

2014/10/27

unknown-ve

3 daysunknown

60s M

2014/11/7

Liberia-ve

2 daysStreptococcal
pharyngitis

30s M

2014/12/29

Sierra Leone-ve

2 dayssinusitis

70s F

2015/1/18

Sierra Leone-ve

3 daysinfluenza A

12 34MMWR Morb Mortal Wkly Rep. 2015 Sep 11;64(35):981-4.

goggleN95 mask

Face shield

double gown

double grovePPE in our instituteshoes coverboot

FilmArray®
multiplex PCR system•

Simple: 2 minutes of hands-ontime•

Easy: No precise measuring orpipetting required•

Fast: Turnaround time of about anhour

Laboratory in ID unit.

・CBC and chems
・Rapid Test(Malaria, Dengue, etc..)
・PCR(EVD)
・LAMP（MERS, H5N1,etc…）

MERS, avian flu

MERS, avian flu•

Classified as type 2 infectious diseases•

Probable cases should be admitted to “Specified /Category 1 or 2 infectious diseases hospital”•More than 300 hospitals are assigned to care thepatients of type 2 infectious diseases including MERS
and avian flu

Medical institutions designated for type II infectious diseases

340 Hospitals locatedevery secondary medical care area

The definition of suspected cases ofMERS during outbreak in Korea(I)Patients with fever, respiratory symptoms, and the findings ofpneumonia with history of travel to the MERS endemic countries
within 14 days
(II)Patients with fever, respiratory symptoms, and the history of medicalvisit, or exposure to the patient of MERS / camels, with history oftravel to the MERS endemic countries within 14 days
(III)Patients with fever, or respiratory symptoms, and the history ofexposure to the confirmed MERS patients within 14 days

LAMP method for
MERS-CoV detection•Loop-mediated Isothermal Amplification is a
simple, rapid, specific and cost-effective nucleic
acid amplification method solely developed byEiken Chemical Co., Ltd.

•It takes only 30 minutes to detect pathogens
including MERS-CoV.

•We have multiplex LAMP method system in ourlaboratory in ID unit.

Chip Layout
MERS
H7H3H1pdm
Flu B
Flu A

3cm

igned by Dr. Kageyama, National Institute of Infectious Diseases, Japan and EIKEN