Jpn. J. Infect. Dis., 52, 1999

Laboratory and Epidemiology Communications

Salmonella Oranienburg Involved in a Variety of Diseases● ●Kokichi Hamada*and Hidetaka TsuJI

Division of Microbiology, Hyogo Prefectural Institute of Public Health
Arata‑Cho 2‑1‑29, Hyogo‑Ku, Kobe 652‑0032, Japan
Communicated by Shunsuke lmai

(Accepted November 1 1, 1999)
各∫and S. paratyphi A (5). The systemic infections caused by S･
Oranienburg reported here thus need attention･ The vertebral

Salmonellosis caused by contaminated cuttlefish chips

spread throughout Japan from December 1998 to May 1999.
We first identified Salmonella Oranienburg (1,2) and S.

infection observed in case 3 represents a rare clinical phenom‑

Chester (3,4) as causative agents. During the outbreak, weenon. However, a similar case was reported in the sameobtained 62 S. Oranienburg and 12 S. Chester isolates fromdiarrhealstools collected in Hyogo Prefecture in the central partoutbreak, a retroperitoneal abscess was observed in an 8 year‑of Japan. However, the source of isolation was not restricted tocontaminated with Salmonella (6).

old female who was infected by ingestlng Cuttlefish chips

stools･ S･ Oranienburg was isolated from various parts of thebody, suggesting that the Salmonella caused systemic infec‑REFERENCES

tion.

Case 1 was a 68‑year‑old female whose chief complaints were

1. Hamada, K., Tsuji, H. and Masuda, K･ (1999): An outbreakabdominal palm, diarrheaand nausea. She had cholecystitiS. Herbile juice contained S. Oranienburg. Case 2 was a I 3‑year‑oldof Salmonella Oranienburg ln the Hyogo Prefecture･
Infect. Agents Surveillance Rep., 20, 87 (in Japanese)･

male who had enterocolitis‑associated nausea and purulent

2. Hamada, K., Tsuji, H., Masuda, K. and Uemura, K･gonarthritis. S. Oranienburg was isolated from coxal pus. Case

( 1 999): Outbreak of salmonellosis caused by ingestion of
cuttlefish chips: EpidemiologlCalanalysis by pulsed‑field●●

3 was a 12‑year‑old female who had abdominal pain due to●enterocolitis･ She was diagnosed as havlng OSteOmyelitis ofgel electrophoresis. Jpn. ∫. Infect･ Dis･, 52, 53‑54･

the splne. S. Oranienburg was isolated from vertebral bodies.

3. Tsuji, H., Hamada, K. and Masuda, K･ (1999): Evidence

Case 4 was a 3‑year‑old female whose chief symptom wasfor the mixed infection by Salmonella Chester and S･●●Oranienburg ln the outbreak caused by contaminatedcuttlefish chips Ingestion in Japan 1999･ Infect･ Agentsfever･ She had purulent gonarthritis which resulted in sepsis.

●A blood culture revealed infection with S. Oranienburg. Case

Surveillance Rep., 20, 167‑168 (in Japanese)･

5 was a one‑year‑old female who had diarrhea. She was

septicemic with S. Oranienburg. All five patients had ingested
cuttlefish chips "Oyatsu‑Chinmi".

4. Tsuji, H. and Hamada, K. (1999): Outbreak of salmonelI&The five isolates were examined by pulsed‑field gelby both Salmonella Chester and Salmonella Oranienburg･

Sis caused by ingestion of cuttlefish chips contaminatedJpn. J. Infect. Dis･, 52, 138‑139･

eletrophoresis (PFGE) by using a Gene Path Typing System

5. Darwin, K.H. and Miller, VL. (1999): Molecular basis(Nippon Bio‑Rad, Tokyo). PFGE patterns of BlnI or Xbal
digests of the chromosomal DNA were compared. All of theof the intemction of Salmonella with the intestinalmucosa.

Clin. Microbiol. Rev., 12, 405‑428.

isolates had an identical pattem. The pattem was also identical

6. Iinuma, Y., Andoh, H. and Agata, N. (1999).. Retroperi‑

to the one exhibited by the isolates from diarrheal stool and■toneal abscess due to Salmonella Oraneienburg ln anfrom cuttlefish chips.

eight‑year‑oldgirl. Infect. Agents Surveillance Rep･, 20,Enter∝Olitis is the most common symptom of salmonello‑

139‑ 140 (in Japanese).

sis. Systemic infections can be produced by Salmonellae but

are relatively rare when produced by species other than S.typhi*ComSpOnding author: Fax: +8ト78‑53 1‑7080

219