Parasa S,​ Desai M, Thoguluva Chandrasekar V, et al. Prevalence of gastrointestinal
symptoms and fecal viral shedding in patients with coronavirus disease 2019: A
Systematic Review and Meta-analysis.
JAMA Netw Open. 2020;3(6):e2011335. Published 2020 Jun 1.
doi:10.1001/jamanetworkopen.2020.11335
Table 1 Parasa S 2020. Characteristics of the Included Studies
SourceSetting

Population

Patientnumbers

Chen et al

Zhongnan Hospital,Wuhan, China

Pregnant women withlaboratory-confirmed COVID-19
pneumonia

9Zhang et a​l

Jinhua Hospital, China

Patients with laboratory-confirmed
COVID-19 pneumonia

14

Wang et al

21 hospitals in 17 cities Childrenin, China

31

Xiao et al

Guangzhou, China

Hospitalized patients with SARS-CoV-2
detected in stool73

Ling et al

Shanghai, China

All patients with COVID-19 in Shanghai
region66

Liu et alhospitals in Hubei
province, China

Patients with COVID-19 admitted to therespiratory departments

137

Yang et al

Wenzhou, China

Patients with SARS-CoV-2 infection
confirmed via RT-PCR

149

Xu et alhospitals in Zhejiang,
China

Hospitalized patients withlaboratory-confirmed SARS-Cov-262

Liu et al

Jianghan University
Hospital, Wuhan,
China

Physicians and nurses

30

Guan et alWuhan, China

Adults with SARS-CoV-2 infection

1099

Huang et a​l Wuhan, China

Adult patients

41

Chen et alWuhan, China

Adult patients

99

Wang et al

Zhongnan, Wuhan

Adult patients

138

Zhang et al

Fever clinic in Beijing,
China

All patients

9

Chen et al

Wuhan, China

Patient admitted to the isolation ward

29

Wang et al

Shanghai, China

Patients receiving combined Chineseand Western medicine

4

Chang et a​l Beijing, China

Hospitalized patients13Pan et a​lWuhan, China

Adult patients204

Luo et alWuhan, China

Hospitalized patients

1141

Zhou et alWuhan, China

Medical staff and nonstaff patients254

Jin et al

Zhijang province,China

Adult patients651

Preprint studies
Zhang et alHubei, Shiyan, China

Patients aged 0-14 y34

Qian et alWuhan, China

NA91

Fan et al

Shanghai, China

Patients aged 15-88 y148

Zhao et al

Hospital of Universityof Science andTechnology of China

Patients aged 16-91 y75

Han et alWuhan, China

Hospitalized patients aged 27-92 y206

Xu et alGuangzhou, China

Pediatric patients

10Wu andMcGoogan

Multicenter CDC
database

72 314 case records

44 ,672

Liu et alUnion Hospital,Wuhan, China

Patients aged 23-63 y64

References

Chang D,​ Lin M, Wei L, et al. Epidemiologic and clinical characteristics of novel
coronavirus infections involving 13 patients outside Wuhan, China. JAMA.
2020;323(11):1092-1093. doi:10.1001/jama.2020.1623
Chen H​, Guo J, Wang C, et al. Clinical characteristics and intrauterine verticaltransmission potential of COVID-19 infection in nine pregnant women: a retrospective
review of medical records. Lancet. 2020;395(10226):809-815.
doi:10.1016/S0140-6736(20)30360-3
Chen L​, Liu HG, Liu W, et al. Analysis of clinical features of 29 patients with 2019
novel coronavirus pneumonia [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi.
2020;43(3):203-208.
Chen N,​ Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99
cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.
Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7
Fan Z,​ Chen L, Li J, et al. Clinical features of COVID-19-related liver damage. Clin
Gastroenterol Hepatol. 2020;3565(20):30482-1. doi:10.1016/j.cgh.2020.04.002
Guan WJ,​ Ni ZY, Hu Y, et al. China Medical Treatment Expert Group for Covid-19 .
Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med.
2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
Han C, ​Duan C, Zhang S, et al. Digestive symptoms in COVID-19 patients with mild
disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J
Gastroenterol. 2020. doi:10.14309/ajg.0000000000000664

Huang C,​ Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel
coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.
doi:10.1016/S0140-6736(20)30183-5
Jin X, ​Lian JS, Hu JH, et al. Epidemiological, clinical and virological characteristics of74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal
symptoms. Gut. 2020;69(6):1002-1009. doi:10.1136/gutjnl-2020-320926
Ling Y,​ Xu SB, Lin YX, et al. Persistence and clearance of viral RNA in 2019 novelcoronavirus disease rehabilitation patients. Chin Med J (Engl). 2020;133(9):1039-1043.
doi:10.1097/CM9.0000000000000774
Liu J​, Ouyang L, Guo P, et al. Epidemiological, clinical characteristics and outcome ofmedical staff infected with COVID-19 in Wuhan, China: a retrospective case series
analysis. Preprint. Posted online March 13, 2020. medRxiv 2020.03.09.20033118.
doi:10.1101/2020.03.09.20033118
Liu K,​ Fang YY, Deng Y, et al. Clinical characteristics of novel coronavirus cases intertiary hospitals in Hubei Province. Chin Med J (Engl). 2020;133(9):1025-1031.
doi:10.1097/CM9.0000000000000744
Liu M,​ He P, Liu HG, et al. Clinical characteristics of 30 medical workers infected withnew coronavirus pneumonia [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi.
2020;43(3):209-214. doi:10.3760/cma.j.issn.1001-0939.2020.03.014
Luo S, ​Zhang X, Xu H. Don’t overlook digestive symptoms in patients with 2019 novelcoronavirus disease (COVID-19). Clin Gastroenterol Hepatol.
2020;S1542-3565(20)30401-30408. doi:10.1016/j.cgh.2020.03.043
Pan L,​ Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients withdigestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study.
Am J Gastroenterol. 2020;115(5):766-773. doi:10.14309/ajg.0000000000000620
Qian G-Q,​ Yang NB, Ding F, et al. Epidemiologic and clinical characteristics of 91
hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centrecase series. QJM. Published online March 17, 2020. doi:10.1093/qjmed/hcaa089
Wang D,​ Ju XL, Xie F, et al. Clinical analysis of 31 cases of 2019 novel coronavirus
infection in children from six provinces (autonomous region) of northern China [inChinese]. Zhonghua Er Ke Za Zhi. 2020;58(4):269-274.
doi:10.3760/cma.j.cn112140-20200225-00138
Wang D, ​Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With
2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA.
2020;323(11):1061‐1069. doi:10.1001/jama.2020.1585
Wu Z,​ McGoogan JM. Characteristics of and important lessons from the coronavirus
disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases
from the Chinese Center for Disease Control and Prevention. JAMA. Published onlineFebruary 24, 2020. doi:10.1001/jama.2020.2648

Xiao F,​ Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection ofSARS-CoV-2. Gastroenterology. 2020;158(6):1831-1833.e3.
doi:10.1053/j.gastro.2020.02.055
Xu Y, ​Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection andpotential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-505.
doi:10.1038/s41591-020-0817-4
Xu XW,​ Wu XX, Jiang XG, et al. Clinical findings in a group of patients infected withthe 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective
case series. BMJ. 2020;368:m606. doi:10.1136/bmj.m606
Yang W,​ Cao Q, Qin L, et al. Clinical characteristics and imaging manifestations of the2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city,Zhejiang, China. J Infect. 2020;80(4):388-393. doi:10.1016/j.jinf.2020.02.016
Zhang C,​ Gu J, Chen Q, et al. Clinical characteristics of 34 children with coronavirus
disease-2019 in the west of China: a multiple-center case series. Preprint. Posted
online March 16, 2020. medRxiv 2020.03.12.20034686.
doi:10.1101/2020.03.12.20034686 36.
Zhang J, ​Wang S, Xue Y. Fecal specimen diagnosis 2019 novel coronavirus-infectedpneumonia. J Med Virol. Published online March 3, 2020. doi:10.1002/jmv.25742
Zhang MQ,​ Wang XH, Chen YL, et al. Clinical features of 2019 novel coronavirus
pneumonia in the early stage from a fever clinic in Beijing [in Chinese]. Zhonghua Jie
He Hu Xi Za Zhi. 2020;43(3):215-218. doi:10.3760/cma.j.issn.1001-0939.2020.03.015
Zhao Z,​ Xie J, Yin M, et al. Clinical and laboratory profiles of 75 hospitalized patientswith novel coronavirus disease 2019 in Hefei, China. Preprint. Posted online March 6,2020. medRxiv 2020.03.01.20029785. doi:10.1101/2020.03.01.20029785
Zhou Z, ​Zhao N, Shu Y, Han S, Chen B, Shu X. Effect of gastrointestinal symptoms onpatients infected with coronavirus disease 2019. Gastroenterology.
2020;S0016-5085(20)30362-30370. doi:10.1053/j.gastro.2020.03.020