Division of Biofunctional Chemistry
The Chemical Society of Japan
Vol. 22, No.4 (2008. 3. 3)I   ?
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 DNA yªďã(0 'ZFYJI¡6õ$ê",Ûâ#Ûâ(Æ$&() DNA $¬3´ÒÍĂ(Ûâ#(¬®6Ñ÷3,'ó"DZ^cgD_e-BeT^gG#Ċ7#"

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N

N

&

N

N
H

NH

NH
O

H
N

N

N
H

O

O

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O
N

N

N

N

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O
N

N
H
H
N

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O

N
H

H
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N
H

H
N

N
O

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O
N



N

N

N

N

O
 

öó@VP1 DNA ßo#ÔÖ 7-9^áã"}-O;N?>$(

polymerase5' å¸O;N?>Äxn$*,(GGGATT)n3'

5'Y§ã DNA "(O;N?>m¨-*"«Ûr/ÕØÄx-²¹!n´±"h¨O;N?>$Ý`/¤%ligand-stabilized
hairpin structure

5'



5'

3'

sê!}-'eàÂn = 4 A T T GGG A T T GGGATTGGGATTGGGATT
n = 3 A T T GGG A T T GGGATTGGGATT
n = 2 A T T GGG A T T GGGATT"*,º"éu.%
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#

GT n = 2AC£¥(,%Y§-²¹!«Û"Äx-]/Ð

NT

30 μM

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TMPyP4

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NT

10 μM

TMPyP4#Å,ÚßoIB$ d(TTAGGG)
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GT n = 4AC%YµÁ$Y§ã}#-÷áã$»ÀÇ/ð\)%!

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NT

3 μM

#

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flipped out
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NA2

S:W195GVW#°ïCAG/CAG
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flipped out
cytosine"$c([wÒÊiÁ½Íè#ji´#«Û/ NMR ¢+"Z%ñ|öò#«Û$DK>S:W7
1EW

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CAG/CAG:1'#" NACPK&% 
!&%  *(Äx

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OH OH

HO

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Taq polymerase

L-DNA

T
T

Ê#cy®!

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template

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+ d(CGG)n LEQ@!¹h+_xOHTT"Ò­(DNA .X+_xDNA"_x¸"Ò­!
  
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TT

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OH

T
T

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©!#

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(a)

h

h

%×mÛØ
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 SÇ²µ|360 nm+uÓu

430 nmy¨´y²µ!#"Au

AC>5CO9Q²µ.¾È¨´yAC>5CO9Q:P;Q

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!²µ|.

+!

TDNA·º

AC>5"

'a©,+T
Y

DNA3X:

5'

3'

HS-A15-TTACXGAAACXGAATGATACATATGTATCAT
ATTGGCTATGGCTTATCTATGTATACATAGTA(b)state 1A

C

G

T

state 2 (+ 360 nm)"¥#Ï`¥«®

UÐÑ

(c)

360

430

360

430 nm

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C
4

state 1

2

state 2state 3

G

0

TA
0

50


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time (min.)

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100

T

T
T

state 3 (+ 430 nm)

7CIcy.AC>5!
²µ.Òw%DNA

T

3'

DNA4 :

)

Au

150

 DNA Ï¹º!`àá



1)

H2N
H2N

NH

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* CAG/CAG FIAS:V386

H
N

GUV"ïóîÒ|f¨Ý

!Â'

Lys N
H

N

!

l"#OBA
/

N
H

N

430 nm
360 nm
0.5

OH
O

0

O

ISBJ35D#Ò|f
Ì

2)

O

430 nm¨Ý"!#&[NHNH

SPR intensityÌ`¦" DNA á1-|0.q

360 nm



-0.5
-1
-1.5

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-2

N

N

0

$"X¡~1r.ÃX\d,'u°oz.`àá,X¦á²$_

200

400

600

800

1000 1200

Time (sec.)

P>`àá

532#($ &"  %/.!*6,- 42'$ 0  ) +1

p§.Ã`\d1Ém¯!+-X¦á,`àá`àá,X¦á$Ï! DNA 1gp§.ÃY\d"mÄ DNA "qÅ1ã¹'b"q1hFGC7GU:W½Á1ß).^ëðì
òíeq RNA "Ê|r 19
 DNA !¬% RNA #iº!"¨ÝÒæ´"À"¥©x"¼Ø# RNA "¨Ý1±¸º!×Ø.q1ÖÕ._#è-''SM;4BAqË«RNA !#''Ê|!+- RNA `ª¨Ý1,»!#qÖÕp§*©ÎÓx.q*¢ésÑ"RNA #eqk"¨Ýx!Þw RNA "Ê|1 ON/OFF .3JUWA½Á1ß)'mÄ"3?KV=V
1È(Û2LJAE!Ê|. RNA 14VHDU<T79QV!+-yç'LJAE1Æm1¯DRV;
1¯9;,9;f!¸x.LJAE# RNA,Ôç'â­âm

,DRV;f!¸x.lÜ-LJAE# RNA !Ê|'ëñì"å! RNA "`ª¨Ý

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m!Ä.SM;4BA1s(' Çc½Á#n}½ÁÍaêÐ½ä¶½]Ù½";@BIN;E
7µ2"vt"Ê¤"1j-{¿·Z'³(1) A. Okamoto et al. Angew. Chem. Int. Ed. 1999, 38, 3378-3381. (2) S. Sando et al. J. Am. Chem. Soc. 2000,
123, 2172-2177. (3) S. Sando et al. Nat. Biotechnol. 2001, 19, 51-55. (4) S. Sando et al. J. Am. Chem. Soc. 2001,
124, 14580-14585. (5) A. Kobori, et al. J. Am. Chem. Soc. 2004, 126, 557-562. (6) S. Hagihara et al. Nucleic
Acids Res. 2004, 32, 278-286. (7) S. Hagihara et al. J. Am. Chem. Soc. 2003, 125, 662-666. (8) Y. Goto et al.
ChemBioChem 2007, 8, 723-726. (9) M. Hagihara et al. ChemBioChem 2008, 9, in press. (10) S. Hagihara and C.
Kojima et al. Nat. Chem. Biol. 2005, 1, 39-43. (11) T. Peng et al. Angew. Chem. Int. Ed. 2005, 44, 7280-7283.
(12) K. Nakatani ChemBioChem 2004, 12, 1623-1633. (13) G. Hayashi et al. ChemBioChem 2007, 8, 483-485.
(14) F. Takei et al. Chem. Eur. J. 2007, 13, 4452-4457. (15) Y. Goto et al. Anal. Bioanal. Chem. 2007, 388,
1165-1173. (16) T. Peng and C. Dohno et al. Angew. Chem. Int. Ed. 2006, 45, 5623-5626. (17) C. Dohno et al.
ChemBioChem 2007, 8, 483-485. (18) C. Dohno et al. J. Am. Chem. Soc. 2007, 129, 11898-11899. (19) G.
Hayashi and M. Hagihara et al. J. Am. Chem. Soc. 2007, 129, 8678-8679.

-5-

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Scheme 1

S– Trithiocyanurate

H2O
HN

N

NH
N

H

1
2+
Zn –cyclen (ZnL1)
X–(anion)

R1

-S

R1

X–
NH

HN

N

2

H

ZnL1–X– complex

R1 =(TCA3–)-S

N N NS
-S

Guest

R1

in H2O

HN

N
N S–
+

–S

Zn2+
HN

<l`Z]9'H%# 

N

NH

HN

N

N
N

in H2O
at neutral pH

S-

SN N

S- N S-4 : 4 3–(TCA3-) complex
4
Thermodynamically and kinetically stablewith a guest included

H

3(Zn3L2)  :! ď Úû?$t½xąĆ|"Đ,w­ ÆÊÈw=*(8Ĕ¡Ĕ9ç£ĊÜ2$ß¶ċ|øPdXp KÐ®3H0:Kî25%  :>Ĉ=?¦ê,2$
 ?4>ýÞĈ=ÓÆÖ<RW]K³3H0:91IH%·ù$RW]óõ>ü¯­:³|>­,$RW]>|Ü$RW]>Sq
 >ýÞĈ:>³ðċÜ=}28(H0:,Ù1I5%  @5$¥É¥
ehrUmq$9Å|9'H{ÌÆáK$ÆÊÈw=²±3H0:,9-H%
ēđâåXPq^UQ_phZXqVj r=¡ 3Hü¯ÖøÔXqTr  ď Đw>Zn 2 + ? Á ú   : 2 8 Ñ ( F I 8 * G $ þ z č  9 ' H % Ú û ? $Zn 2 + K ï Æ ­ R W ] = ¡ 3 H L ` O q ó õ ý : 2 8 Ñ ( H Inositol 1,4,5-triphosphateďIP3ĐX q T r K ò ñ $  ® 2 5 ďScheme 2Đ%IP3?$âåUQ_pyûÃÁ=*/H
āí<XPq^hZXqVjr>s79'G$4>¤DË¨>¾=?$ü¯Ö<ÔX-6-

E6Fxª2,2’-bipyridyl»b p y ¼ h 0 B E 4 F ! (  L  Z n 2 + µ U-(Zn2L3)  Ru 2 3 E " ¾ p ½ ¸  U » Ru—N ± T ¡ b ! h   ¼ 5(Ru(Zn2L3)3)0 b |  

7¼

5 #  IP3A;C^b-cis,cis-1,3,5-cyclohexanetriol

triphosphate (CTP3)1p2©bU6 0|-"Xut4W!jk 5 #HBE²

-IP3 )CTP3!p}Xy-\'"^m9E6F

'!XJw0IrµU!PIP39E6F"b|0¨-- f{tcI"
Luminescenceemission

Scheme 2HO
2–O PO
3
2–O PO3binding site for IP3OH

2–O PO
3

OPO32–X

OPO32–OPO32–
OH

Inositol 1,4,5-triphosphate
(IP3)

N

N

IP3 or CTP3

N
N

N

in aqueous
solutionat neutral pH

OPO32–
2–O PO
3N

N

OPO32–

cis,cis-1,3,5-Cyclohexanetriol
triphosphate (CTP3)

binding site for IP3

Zn2+

5
Ru(Zn2L3)3

Ru2+

N

N
N

OPO32–

2–O PO
3

X

OPO32–

6
1:2 complex of 5 and IP3 (or CTP3)
X = inositol or cis,cis1,3,5-cyclohexantriol¾  N´23E§X9E6F"^m µU"X^ m_y Zn 2 + # C a 2 + !    £ Z 7 5 = C R ° 2 3 E    (    . 
#2+" Cy c len g Zn § X ? D F > 0 b |  2+  £ Z Zn  t  I   -   0 i d  

9¼

8¼

-

°

+!1@<F78\¯ ® b |   7a (L4) # Zn 2 + 1

4

p 1 µ U 8 a ( Zn ( H – 1 L ) ) 0  |  -    " § X » 5 1 2 n m ¼  1 7 W j k  - » ] ¬10a) ¶ 3 2 8 n m ¼ » S ch em e 3 ¼
5

8 - q u in o lin o l ! (2+

G  5 - d im e th y l su lf o n y l h 0 q

5Y   7 b ( L ) #  Zn µ U 8 b» Zn ( H – 1 L ) ¼  | ! S, § X ³ l `  ( 7 a !

$k§ X » 478 nm¼  32W !
2+

7 a , b #Zn µ U  º r ! n o» « ¹ oe»¼Zn 2 +  [  a ¤  µ U  |  1  Q Z !

~  fM3 F : F ¼  s
K  - 

10b)

v0(

7 ¦­#JzO®8 - q u in o l in o l " O H h  ¥ ?

D < E ^  . - ! ( · / +  % &  § X -

.#8 - q u in o l in o l " O H h  ?

D < E ^  .  Cy cl en     "  M V  ! * - ( "  ¢  

Scheme 3

R2

Emission

HO
H
N

O-

N

N
2H+
NH
HN

Zn2+

Hydrolysis of
Zn2+-9 complex

Kd = 8~50 fM
at pH 7.4

N

HN

N

HN

NH

7a (L4) :R2 = SO2NMe2:R3 = H

8a (Zn(H–1L4)):R2 = SO2NMe2:R3 = H

7b (L5) :R2 = R3 = SO2NMe2

8b (Zn(H–1L5))

7
Zn2+:R2 = R3 = SO2NMe2

-7-


R2

R2

R3

R3

-

h
Photolysis

R3
O2 S O N
R4 H N
N
nH+
NH
HN
9
Caged L
(R4 = Ph) 7 F ð ô  ·  Ü B á  ¾ ì F Zn 2 + / Cd 2 + ĉ Ä À È ¥ F = K +8 - q u in o lin o l F Õ Ď© T P h S O 2 © A  ā 9 = C ag ed   Û 9 T  Â 9 = ,10c) 9 3 Zn 2 + ď  T ß Â ; Q B +Zn 2 + E Č  9 = H O – 3 P h S O 2 © E µ 9 @ Ö Î É Ç 9 +  Õ  ý â E U n c ag e  ¾ 3
ć ÷ 9 = ( 7 b F  Ù Ë G í 4  ) , Ó ¿ D 3 O Z n 2 + /Cd 2 + ĉ Ä À G È ¥ A 4 D 2 > = 9 + Z n 2 + T lo ad 9 = H e L a ð ô  A F

3 + 9F ð ô  ·  Ü G 10. 12 μMI A

Zn 2 + Ï  E L Â  9 = , I = + 9 F q } c } a z r l z © G  Ú ¶ A L U n c ag e 8
R Q 7 B T ü  9 = ,10c) 7FÌý¾G(!#3D5@Lć÷9+< F  ¾ Ò Ð F
ý Í 11) B ê-F¾àTÏÿA/Q,ė  nxm}F¯ĕÎĎÆF¦½ ¾+ąâĎĊĒb}^~Ė ßG+ï«òM×ÀĎîDCÑ-Dai{aE8O8R@0Q,AđÅ;Q?Ffv`}  %3ï«òT¢;QB[2+2]Þ¾Tă79+_\|od}¨fv}eXu~ĕT[c,s]TĖTßÂ;QĕScheme 4Ė,¾Tþ¬;Q, I=F¦½čîA/QnYiyV

F_\|od}ÞHFĒ­éEN>@¦½~cGúčîT¡J+Ċ¨nxm}2O

ñ^XiĄAGiypinU}3Ă´E®§;Q,

 Ã-G;AE+ÎZn 2 + ď3 B°±D µ ûTßÂ9@  Þ¾TĐ
²;Q7B+I=ÎZn 2 + ď 3

2O HF¦½ĕ #"Ú¶ĖTĆ;Q7BTª£9=,  <7Anxm}BiypinU}TÊ;QZn 2 + ď
6

½¾TÏÿ9=B7S+Ċ¨Zn L 6I=Ď¨Zn L 

$'

& 

3

( Zn L 6 ) TÂ9+F¦F¦½¾TĆ;Q7BTü9=,

TE t 3 N ®§AÚ¶;QB+nxm}FĊ3ć÷9@T½A4Q7BL2>=,8OE&%Ó©3nxm}FEµ;Q°±E³9@0QõÀ
3ç¤8R=,
Scheme 4

O

HN
O

Me

Me

O Me

NH

N

N

O
O

P
O

O10

OH

Me O

HN

O

O

O

O
HO

Photo[2+2]cycloaddition
by UV-B, UV-C

O

N

HN

N

HN

O

+ UV-A (>320 nm)

O

O

OH

P

Trp

HN

H2O
H

O
O

O

O
(reduced formof flavin)d(TpT))

HO

O

N

O

N

N
H

H

H

O

Me H
N

NH
N

O-

11
cis-syn cyclobutane
thymine dimer(T[c,s]T)N
NH

12red ((ZnL6) in reduced form) ðôG+Ďai{aE¾:@{jg\a_]ky}]T÷>@0Q,ðôĎĊĒ
ĕ{jg\ath}_wzĖG+]zdfZ}MfZ{j[_}DCFfZ~z*`aznW
j¹ù¾EN>@¼8R@0Q,èĈG+ĀF¸nYiyV~cæë2O+ysnxm}FĎĊĒ3+]zdfZ}DCfZ~zēF<REĄ07BEäã9+nxm}
T{jg\aÏåċ+ĕ$&   ) ##ĖTáċB9@Ê;Qb}^~

TÂ9=ĕScheme 5Ė, óøØ+Ď¨

F

#"E16Qö»ºGĊ¨F

íĘBDP+7Fá¾ìGąâA/>=, F{jg\a¾ìGðôALõA/P+ÔÀL0,Ý§+NPĔÁºF{jg\ab}^~FÂTÏÿA/Q,

-8-



Scheme 5N
O N

HeLa cell

HN

N

O
HN
O

O
NH

N

Me
Me

N
F
NB
F
Me

Me

R

Me

O N O
N
N
N
R

Oxidation
Reduction

BODIPY

O
Me

HN
O
Me

Me
N
F
B
N
F
Me

Me

Me
Flavin(oxidized form)

Me
Flavin(reduced form)
13red
Weak emission

13ox
Strong emission³.   #!
 -)°¤§~|$m/35J?WG

9@{$@[X¢$"q
9@{(($F6c5J9K?W$

x

w

4

0

",T

CK7¡}"B"dhttp://www.rs.noda.tus.ac.jp/aokilab/$p
shinaoki@rs.noda.tus.ac.jp¦$







Q

 ¥´i!U]LU¯_$ hjn(1±ROFKA`^®MFKK¨²ra1±ROFKFK«;sK@²DI8=E±'%&X\² ib1
>HY1z©Nf1±ROFKFK«K²u:¬S1le21±k+
FKPK¨²V Z) 
Reference
1. (a) Auld, D. S. BioMetals 2001, 14, 271–313. (b) Aoki, S.; Kimura, E. In Comprehensive Coordination
Chemistry II, Vol. 8. eds. by Que, L. Jr.; Tolman, W. B. Elsevier Ltd.; 2004, p 601-640. (c) Kimura, E.; J. Acc.
Chem. Res. 2001, 34, 171–179. (d) Kimura, E.; Kikuta, E. J. Biol. Inorg. Chem. 2000, 5, 139–155.
2. (a) Kimura, E.; Shiota, T.; Koike, M.; Shiro, M.; Kodama, M. . J. Am. Chem. Soc. 1990, 112, 5805–5811. (b)Shionoya, M.; Kimura, E.; Shiro, M. J. Am. Chem. Soc. 1993, 115, 6730–6737.
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Shiro, M.; Kimura, E. J. Am. Chem. Soc. 2002, 124 5256–5257. (d) Kimura, E.; Aoki, S.; Koike, T.; Shiro, M.
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M.; Shiro, M.; Kimura, E. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 4894–4899. (c) ­h, go@[9K<.
 2006, 64, 608–616.
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Haino, T. Manuscript in preparation.
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-9-

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2) Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E., Matrix elasticity directs stem cell lineage
specification, Cell 126, 677-689 (2006).
3) McBeth, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K., and Chen, C.S., Cell Shape, cytoskeletaltension, and RhoA regulate stem cell lineage commitment, Dev. Cell, 6, 483-495 (2004).
4) Lo, C-M., Wang, H-B., Dembo, M., and Wang Y.-L. Cell movement is guided by the rigidity of thesubstrate. Biophys. J. 79, 144-152 (2000).
5) Gray, D.S., Tien, J., and Chen, C.S. Repositioning of cells by mechanotaxis on surfaces withmicropatterned Young’s modulus. J. Biomed. Mater. Res. 66A, 605-614 (2003).
6) Choquet, D., Felsenfeld, D.P., and Sheetz, M.P., Extracellular matrix rigidity causes strengtheningof integrin-cytoskeleton linkages, Cell 88, 39-48 (1997).
7) Kidoaki, S. Matsuda, T., Microelastic gradient gelatinous gels to induce cellular mechanotaxis., J.
Biotechol. 133, 225-230 (2008).

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3A4- 25 7)ĝƹ@8eœŵƂ½īöħģǖjåŻÂǇå
ƆţÉǗÛ¢ǕÇàĶÇXĥǕƏÇXÖ¶¨ōXĖ\Ŧ
3A4- 26 `ǀǒĞ{Ǐ<'T#49¥DNAƿ²ǀŏ HRL
QY1ùǖſǐÂǇåǗĮàĿZXÞáƣèXğĩǌXØáí
ČXŀhÌČ
3A4- 27 DNA fĨģƬƞƠ {ǏDNA D2IYďÖħƃƝwǖſǐÂǇåǗğĩǌXġƗƑëXũĘĆìXØá
íČXŀhÌČ
3A4- 28 B!:V8URVY8R.JVƓ¡uDNA ĉǖſǐÂǇåǗØáíČXŰWŁňXĊhXğĩǌXŀhÌČ
3A4- 29* RVƹŲƷrÇÕ DNAĉǓŉ ùŏǖėÂŧşǗLonnberg, Tuomasû¹ǊZƴXƾĒƑÃXÖÎÛśîǁ ǔƦŢßǖ10ǘ10Ǚ11ǘ10Ǘ PCąŹĎǃ10ǘ00Ǚ10ǘ10 ǖ4A4-08, 4A4-09, 4A4-10, 4A4-12Ǘ
4A4- 08 ¬ƺǀDNA fƼŏEKĝƹ ÇƜƚƒǖŪĳÂǇćŅǗsaǃŋÇXĭÏŢøXİƻüXƮƕXǁƺųXÛĔĴò
4A4- 09 @86ULƷģƬÖ ÇƞƠǖjÂǇŋǗ[ĀŠÃXś]ŝÇXŰþZXĕÛï
4A4- 10* @86UL>CR59(;V¬ƺǀģƬāŶƧǖjÂǇŋǗś]ŝÇXĕÛï
4A4- 12* @86ULģƬXħƃƘČǖėÂŧşǗõÝXÖÎ
Ûśîǁ ØáíČǖ14ǘ10Ǚ15ǘ00Ǘ PCąŹĎǃ14ǘ00Ǚ14ǘ10 ǖ3A4-32, 3A4-33, 3A4-35, 3A4-36Ǘ
3A4- 32 ƓćRVƹŲƷrÇŏ DNArŽƱĂŖĉǓķúǖėÂŧşǗƾĒƑÃXLonnberg, TuomasXÖÎÛś
3A4- 33* ǓķúŗĄ
1023²DNA"V+K{Ǐǖ£ÂǗĚÑbĠƅ­Xĸıĺb
3A4- 35 NanoBioNow(8) fwƽÚ#VǍÈ®]ƥ>VIYE5
9RG+KĉùÒ PEG  Ç'Q 7V(óǎǖőÂŋåXőÂFIBER XJSPSǗäǊZXŇzÓěX_ƻ{ZXĕĔŘç
3A4- 36 NanoBioNow (9) The structure of G-quadruplex for 5’-UTR mRNAof bcl-2 under molecular crowing conditionǖőÂFIBERXőÂŋåǗðėĺX[ÅÂƨXĕĔŘçîǁ ƉĩƖǖ11ǘ20Ǚ12ǘ20Ǘ
 PCąŹĎǃ11ǘ10Ǚ11ǘ20 ǖ4A4-15, 4A4-16, 4A4-17, 4A4-19,
4A4-20Ǘ
4A4- 15 @86ULƷăRNAG$S658ñÿǖėÂ
ŧşǗšǁƳƎXõÝXÖÎÛŚ
4A4- 16 I .6ULDNAŷ¡ƍŕƤPot1řgvŏI.6ULDNA 4 ĔǀģƬâ¾ǖėŋÂŋǗƽŐƋXǔƦ
Ţß
4A4- 17*
ƐƸĬ6UL DNA 4 ĔǀģƬ ƐƸĬ6UL
DNA ŷ¡ƍŕƤPot1 řgvŏ4 ĔǀģƬâ¾ǖėŋÂŋǗäiŜÇǔƦŢß
4A4- 19 NanoBioNow(6) HSBRV{Ǐĝƹ¥ DNAfƺǀģƬËÍúǖőÂŋåXőÂFIBERǗsqƑžXĖãƢbXĘ
hĻX[ÅÂƨXÎŀĆĈXÛŐǈçXĕĔŘç
4A4- 20 NanoBioNow(7)$4#VúHSBRVDNA ¬ƺǀģƬöǖőÂFIBERXőÂŋåǗĖãƢbX[ÅÂƨXĘh
ĻXÎŀĆĈXÛŐǈçXĕĔŘçîǁ oƌ«ĺǖ15ǘ10Ǚ16ǘ10Ǘ PCąŹĎǃ15ǘ00Ǚ15ǘ10 ǖ3A4-38, 3A4-40, 3A4-41, 3A4-42Ǘ
3A4- 38* NanoBioNow (10) ¦Ʃ ÇŌ¼ùŬ DNA:=.5
4ģůǖőÂFIBERXőÂŋåXJSPSǗŇzÓěX[ÅÂƨXƌĔ| Xő}ZdXZhong-Ming, WangXĕĔŘç
3A4- 40 M-OYSåÉĲŏ2YV#Y?Y² RNA ƙÆǓķúǖcÂǇåǗŞäǉdXŐïìXhäªd
3A4- 41 Caged-nucleotide ŏfƺǀēŧǆƸŴBRYI;AOTY,PVǖėÂŧşǗŐ_©Ã¸ŐmXƊơČųXÖ
ÎÛŚ
3A4- 42* ōu ÇZ ÇĢŗĄ
DNA:=ģƬuǂŔǖėÂŧşǗƊơČųXı×|ÃƴXÖÎÛŚîǁ ÖÎÛŚǖ16ǘ20Ǚ17ǘ30Ǘ
 PCąŹĎǃ16ǘ10Ǚ16ǘ20 ǖ3A4-45, 3A4-46, 3A4-47, 3A4-49,
3A4-50, 3A4-51Ǘ
3A4- 45† V8Q0VfƼŏ
DNAƭŷǖŃĔÂǇƄ
łţÉXJST ǗƪĈƶÇXhĆXŐìX

3Đ29ċôîǁ ĶäƇÇǖ13ǘ30Ǚ14ǘ30Ǘ

-15- PCġƞĪǫ13Ȅ20ȅ13Ȅ30 Ȃ4A4-28, 4A4-29, 4A4-30, 4A4-32,
4A4-33ȃ
4A4- 28 ;_2`¸Įǟ ǁǃ \QC*^%OL;@ȂtÙ$D

3C1- 28 ĻǠÒÌ,b3@¦´ŧ´Ę­ĐđȂķǜÙŭaƹ´

ŧđƁƋ6`9bȃtǰaƇôſ¹a¯Ųíĩ
3C1- 29 ½o£ŧËǹƛƭǙ~áŹŬǂðȂķǜÙŭaƹ

Ɓȃ{ǢƀaƆŲïƶaǩǄø¼naľrâ
4A4- 29 ƿǽƓáǕ¦őMT`Ɯ´đRNA!L9SbŪĊȂŭƁȃĨ¼aǇ¬ĝſaǮǞŒa|ƵÁŖ
4A4- 30* *\<*,T4?\b ĐűĦƻDNAƜ´áĠƚĚő
ǪŹȂķ§ÙaØƁȃrĴþaāŞĬ»aŊņ±
4A4- 32 ¬áǫǷČǨ ű DNA aptamer ǘěȂǣōÙùȃ
éÆaǣŲÕĆaƐŲĬĥaƲǢ¨ƇaŚŉçĨ
4A4- 33 Ʀǐ ŀǓ ĞǥÉ DNAů×Ǚ~áŹŬȂķÙ
ůƁȃǢöǾĆaĲĶ¿ďaƵrǍÛ´ŧđƁƋ6`9bȃÙèƘá¯Ųíĩy,b3@C*^%;@´ĘȂķǜÙŭaƹ´ŧđƁƋ6`9bȃĶǋÜáaÙÈsƸa¯Ųíĩ

3C1- 30 ŅƮW3Yb]Āǩ ¯ŲíĩȂ14Ȅ10ȅ15Ȅ10ȃ PCġƞĪǫ14Ȅ00ȅ14Ȅ10 Ȃ3C1-32, 3C1-33, 3C1-34, 3C1-35,
3C1-37ȃ
3C1- 32 DNA pĴǧ}´ċ· ĐƒđáǪŹȂ1ȃȂǭÙŰƁȃÇraÎǢiƊahǄºĆ
3C1- 33 DNA pĴǧ}´ċ· ĐƒđT4S<;Ɯ´áǪŹ(2)ȂǭÙŰƁȃäǢſlxaÎǢiƊaÝƧƳaÇr
ahǄºĆ
3C1- 34# NanoBioNow(11) ĦƻĐƒđW^(Y[bHb.`ǪŹȂųªÙFIBER aųªÙŭùȃ#b\baųcnaĵĴŽú
3C1- 35* NanoBioNow(12)R\V[b7ǔǧ­ĐǾGC ǶÊDNA Óý Ǖ ářǪŹȂųªÙ FIBERaųªÙŭùȃųcnaĵĴŽú
3C1- 37 +!B`Ʒŗ ű
G ǁǃL_bKǪŹȂħÙùȃȀƵƩǱƕ¬ǱÚaƐǎŃaȀƵšĀǩ hĶčÿȂ14Ȅ40ȅ15Ȅ40ȃ PCġƞĪǫ14Ȅ30ȅ14Ȅ40 Ȃ4A4-35, 4A4-36, 4A4-37, 4A4-39ȃ
4A4- 35 T7 RNA R\V[b7 ű GFP Ǚ~áŹŬċȂ¶ÙȃļƯÃƵõÚaœŲǱcǝaºkŲƍ±aŕŐŖl
4A4- 36 DNAR\V[b7de novo DNA´ĘV&B5UƼĨȂ¶ÙȃļƯÃƵĬ«aŕŐŖl
4A4- 37*  űŸŏŷ ŸƛƭŨŶżǙ~áǑǗ24=UǪŹȂmÙȃÞǅ¥aęrŲaóÚǝaêô¼ıaľaĦŵĝǝaťôŃ
4A4- 39* Ĺńđ!`;6`4ĻǠáłżŏŷ!L_b;( III )ŠƌţÖŶǙ~áǘĜżŹŬċȂtùƤÙǯùƱƈãȃ
Ł®ǿƸáaôµǿáañÍ¼ůaƵƫáaºňčÛaĶdƎ

Āǩ rdïĆȂ15Ȅ20ȅ16Ȅ20ȃ
 PCġƞĪǫ15Ȅ10ȅ15Ȅ20 Ȃ3C1-39, 3C1-41, 3C1-42, 3C1-43ȃ
3C1- 39* ǚ­Đ Ăǣ ƷŹůL_bKǙ~á2+A]ÓýȂŭƁȃ¯øºëaǮǞŒaęŲǲnaüŲƬa|ƵÁŖ
3C1- 41 łżǙ~ádǉưƷ Ź ĦƻƷL_bK´ĘȂŭƁȃŢŲƧºáa¯øºëaĺŲƟaǮǞŒaüŲƬa|ƵÁŖ
3C1- 42 Ŷ\`&bǩ I^` 5ð>%(2#\
3` ¸ƷL_bKǪŹȂƨǼÙǯùȃǤĲǆ¿aľ®įòaƕÑºÛ
3C1- 43* 2\]¦I^`ǂðƷłǃ¦ uù DNA´ĘđǈȂƨǼÙǯùȃľ®įòaǬ®ĎaƵâĆaƕÑºÛĻǠa´ ĘĀǩ õŴĒǱȂ15Ȅ50ȅ16Ȅ50ȃ
 PCġƞĪǫ15Ȅ40ȅ15Ȅ50 Ȃ4A4-42, 4A4-43, 4A4-44, 4A4-45,
4A4-46, 4A4-47ȃ
4A4- 42 Ǚ~áĔÏÌ Ħƻá\\b424=UŀƔȂŭƁȃĺŲƟaǮǞŒa¯øºëaüŲƬa|ƵÁŖ
4A4- 43 J[` ðŅƮđĻǠ*_4\`*ƮƾȂtùƤÙǯùƱƈãȃñÍ¼ůŌŲſuaľŲŘþañśÀaôµǿáaĶdƎ
4A4- 44 DNA R\V[b7 ű´ĘƖǧǸDNA (X[*9["7b2Z`ȂƄęÙǯƠ´uǫƈãȃƺôÁßaǉǭ¢ƗaŲhÿar®ƧǻawõĒƧaŋ¬Ǵu
4A4- 45 (0`?`ǂð ƷğƂƴ ű RNA-\'`@žq űƾȂǭÙŰƁȃĄǦƳĽĴǀƥahǄºĆaÎǢiƊ
4A4- 46# Oxanine-induced DNA-protein crosslink as an useful biomaterial for
elucidation of biological interaction mechanismȂtÙ$DƁȃŻ¤ąaǢøŜa&T6="Ab-`@[*Sb]añȁaŦ
ǢÅƃ
4A4- 47 SAHA conjugate Py-Im R\!T@´ĘƾȂtÙǯŭȃ
ÙİćǖaÇķºaƕ¬ėcaĵôăĀǩ ƕÑºÛȂ16Ȅ30ȅ17Ȅ30ȃ
 PCġƞĪǫ16Ȅ20ȅ16Ȅ30 Ȃ3C1-46, 3C1-48, 3C1-49, 3C1-50ȃ
3C1- 46* ;!8b]%^`3ưƙŧŭãżŨđ űĦƻ
DNAL_bK>1"`ȂŭƁȃŌŲ³aõĴī
3C1- 48 5’ ĳƏJ]%^6"` ĞÂĥǟ Z-DNA pǡǧŨŶżCDȂêôÙǯƴȃžŝaƵĴºkardïĆ
3C1- 49 ģîơŤî ŅƮ uùDNA ǪŹ N(3)-P]T];T3`¸Į%\/Sb´ĘŅƮƾȂtÙǯùȃĿŲƪǌaŲǛcvaƺĴŚc
3C1- 50* XơŤîeŔđ¦ŅƮđuùĻǠǪŹȂtÙǯùȃ
ŲǛcvag¯ƝƧaƺĴŚc

C1 }Ð
5²Ǻ5401Ĥè

3ĭ29ħ©ĻǠa´ ĘĀǩ ºŲĆȂ9Ȅ00 ȅ10Ȅ00ȃ PCġƞĪǫ8Ȅ50ȅ9Ȅ00 Ȃ4C1-01, 4C1-02, 4C1-03, 4C1-04,
4C1-05ȃ
4C1- 01 ÒÌǸÉ4I`[N]¦%\/C*^%;@´Ę ŉL_?`ƢºƮƾȂmÙǯƴȃƵǱcıaǿůſŭáa¾ŝēa¯Ǉź
4C1- 02 ƖǞĮŅ4I` Ǹ
%\/C*^%;@´Ę ŉL_?`ƢºƮȂmÙǯƴȃõ÷ǿÜæaƵǱcıa¾ŝēa¯Ǉź
4C1- 03 DNA cǳáǠ¦P]T]#[2]ůĘȂtÙǯ
ŭȃêŊÙŎaŲzƍaĵôă
4C1- 04† ǠÒÌƽà!6;]G4;3`%(1B`(0`;`ŀǓÖĢȂtÙǯ$D])bȃÄrĩåaŻ¤ąaǢjø
ŜañşaŦǢÅƃ
4C1- 05* I\T3`Ǡ¦¡ūì ǟĈǵȂŭƁȃǢĶƎ
áaŲrhcǆõĴīůŅƮǬǔ¦ãaF"%=*E_3b3ĭ28ħ©ĉĻǠa´ ĘĀǩ õĴīȂ13Ȅ00ȅ14Ȅ00ȃ PCġƞĪǫ12Ȅ50ȅ13Ȅ00 Ȃ3C1-25, 3C1-26, 3C1-27, 3C1-28,
3C1-29, 3C1-30ȃ
3C1- 25† Ŷđ¦C*^%2@, 8-styryl-2’-deoxyguanosine´Ę°ǒżŶđ¦­ĐȂŭƁŲF"%ùãȃñƑ¬ĖŏaȀƵšaŲŮÛ
3C1- 26 ǂǊǳáf Į M!I`É DNA´ĘáǳáƉ£­ĐđȂtÙǯùȃĸsƸáa|ƵǱaǏƵĨáaƺĴ
Śc
3C1- 27 ƣž6-!1#\3` Ǌũĕ:"AT*4ȂķùÙǯŭùȃñĸǾÔaǤĲŇaûĶƅpǝ

-16-õǙ ãÅǉŌǶ10Ǹ10ǹ11Ǹ10Ƿ PCċƐğǛ10Ǹ00ǹ10Ǹ10 Ƕ4C1-08, 4C1-09, 4C1-11, 4C1-12,
4C1-13Ƿ
4C1- 08 K(C\O^`ǎƸß"ÉÆǋǌ³Ʈǋ½ÕĘƮ
ML<A[OĲǎ(PRNA)±ćpH ­ǂŰRNA ǗùćþǶǝÏîǷf°ĆcǊa¸ŧúaķűaĺćatei
4C1- 09* Õŀǥƣ"Ħ
ML<A[OĲǎ(N-PRNA) ±ćDNARNAŲrŦƯĭǶǝÏǞîǷśåla¸ŧúaĺćaķűatei
4C1- 11 NanoBioNow(1) DNAƎ±Õ DNAqǐǘhĎÉÆÝÃvîD/]*5AļǃþǶũ¦ÏFIBERaũ¦ÏŢîaǀŭ
ÏMEIaǀŭÏťĻŢîǷhǑcaçƪvaǱƺĦðaeƬ¸laƥtďóaĩĨűï
4C1- 12 NanoBioNow(2) ĎÉÆÝÃvîD/]*5A ÉÆƷƹǶũ¦ÏŢîaũ¦ÏFIBERaǀŭÏMEIaǀŭÏťĻŢîǷçƪvahǑcaǱƺĦðaeƬ¸laƥtďóaĩĨűï
4C1- 13 DNA ¢Øǫ"
$6[6C'SƸß [`ǎ)7>\¢ǶīîÏaǞŤ·ŢîaK^`>%$ǷŵśqǊagǈìǢxaíêƙaçŪąǢ

ŘcǊaƥja¿tƂŅ¶aǅĝƙaĬňĞõǙ ĪeƪqǶ15Ǹ50ǹ16Ǹ20Ƿ
 PCċƐğǛ15Ǹ40ǹ15Ǹ50 Ƕ4C1-42, 4C1-43, 4C1-44Ƿ
4C1- 42† ƧƟƋ¡[P9bS ōčm¢ØŞƼĹ­ƝĄǶÏǷhĳÕai 
4C1- 43 K\/@4R`[`ǎ¢ǍƋ"Ŧ ƈ¢ƦůƼG&*8`5`0ǶīƽîÏîǷőíơÕæŧŴŨƙaoäƙžaĚô°
4C1- 44 ÷ĶǪ¹ƈ¢aG&*):Fb\ťŤ57>SļƄǶ£ǟƁÏǞQ>[$\4&)`7Ƿà¾ƙƻaŊŧǡǃaŷí
źaæĪěòaǰĪŻaņƺıcC2 |Ç
5 ¯Ǭ 5402 đÛŤĿƝǜǄ¢ØaG&*>/F^6b
3ĥ28ę¤ýML<AõǙ ŉ©ǦvǶ11Ǹ20ǹ12Ǹ20Ƿ
 PCċƐğǛ11Ǹ10ǹ11Ǹ20 Ƕ4C1-15, 4C1-16, 4C1-17, 4C1-19Ƿ
4C1- 15 PRNA-PNA-DNA-TZvîĲǎ±ćĲǎƷƹþ
RNase H ŒĄĹƱǶǝÏǞîaī£ÏÎŸaPRESTO, JSTaICORP)`@^JbþL^, JSTǷňƭźa¸ŧúaĺća
ķűatei
4C1- 16 $\.C`µĦ-ML<A[OĲǎRNAǗùćĊÝ8[`ßįǶǝÏîaPRESTO/JSTaICORP/STǷƬâĜŐa¸ŧúaĺćaķűatei
4C1- 17*†§ĒDNA P[QbǍƋ±ć!"ǖÃ LZ<BBF_&VbƫǶ£ÏǞŢa£ÏǥÕŸǷŧhaĬâÖaãÅǉŌ
4C1- 19* /[=/1R7@[b BK:]`6&RAƔƿÃ
DNA &`:+]b:$;Q`:`-5/^?-7@[`ßǶkîÏîǷÏÈÀcaàŚƊòaƂhƕƗõǙ Ĭŕ¸Ƕ13Ǹ00ǹ14Ǹ00Ƿ PCċƐğǛ12Ǹ50ǹ13Ǹ00 Ƕ3C2-25, 3C2-27, 3C2-29Ƿ
3C2- 25* ƞŮŰǯĴÌČªă şłǯĴµĦML<AƛƳ±ć
ǶīÏǞîaīÏƁŸǷýƥĽa¬xaĪeƪaƤƪ
Ĝ
3C2- 27* [O9bS ǧÐŜÃţŠ¢ML<A±ćŤŢŒĄƶ
ǶīÏǞîaīÏƁŸǷ¬xaýƥĽaĪeƪaƤ
ƪĜ
3C2- 29* Ǉ}ģ¯[L^0ZR`0Ĉƨ"Ŧ N T<\¢ML<A[O9bSƛƳ±ćǶīÏǞîaīÏƁŸǷíeǡ®aĪeƪaƤƪĜõǙ ĪeƪǶ14Ǹ10ǹ15Ǹ10Ƿ PCċƐğǛ14Ǹ00ǹ14Ǹ10 Ƕ3C2-32, 3C2-33, 3C2-34, 3C2-35,
3C2-36Ƿ
3C2- 32 ǍƋŎ ǧ:`H/$RFǎµĦML<A±ćǶāéÏ
îǷi ~ŌaǭícaĸĥƚaíÅ¨
3C2- 33 s¼Ýż@[L@K#`6=HbML<A3`6W2b@ƞïǤ±ǶkÏǞîaJST  ǷĪǏ¸laĬŕ¸a´ÈÒ
3C2- 34 pƍƗ¢ 3`NTb5Y`"Ħ
d¼Ýż0\:<*`3`6W2b@ŇhƞïǤ±ǶkÏîakÏǞîaJST  ǷƥǑĔxaĪǏ¸la´ÈÒaĬŕ¸
3C2- 35 I@-5D/]&`Ƙǁ ǌÌŬß ƓƑ¢ûǩǶīƽîÏǞîǷĚô°©ŧǵcaǓĂ aàĮǣĽaàĮÍ×
3C2- 36* :':`H/ƼǤĄ3$ML<A$R^&AƖƑùć[`ǎ¢įǶuÏ)EŸǷteǣĕaƬëºòawǑ¥aķtÖ3ĥ29ę¤ý
ţÊG&*>/F^6baǪ¹G&*>/F^6ba
G&*8`4bõǙ ŧhǶ13Ǹ30ǹ14Ǹ30Ƿ
 PCċƐğǛ13Ǹ20ǹ13Ǹ30 Ƕ4C1-28, 4C1-30, 4C1-32, 4C1-33Ƿ
4C1- 28* ǕBFƇÕ"ŦŒĄǎƋŽÚǒŎļƄǶīîÏǞƒŢ
îǷǆƥǅǊaİŧ ÕaśŃ
4C1- 30* Q&/^<U`Gb$]&"ŦĀáǒPCR cƌƜƯĭǶǝÏǞîǷĖƥŴvaņƺıc
4C1- 32# Development of a microfluidic biosensor connecting to localized
surface plasmon resonance for biomedical diagnosisǶ£ǟƁÏǞQ>[$\4&)`7aǝÏǞîǷHA MINH, HiepaĖƥŴvaņƺıc
4C1- 33 Î<U`E\K#&GbÃ5W,b<=L ƈǘŲrŦƯĭǶǲéÏǞŢîǷơâǣôaľŉařƾų{aàíĢÓaøǑšaŝŧcaǴƥēaĵíŖÑǊaǠŧŏŤõǙ ÏŋƙÔǶ15Ǹ20ǹ16Ǹ20Ƿ
 PCċƐğǛ15Ǹ10ǹ15Ǹ20 Ƕ3C2-39, 3C2-40, 3C2-41, 3C2-42,
3C2-43Ƿ
3C2- 39 A$R^&AML<A$RFǎy ļǃþǶ£ÏǞŢǷŔŗƪlaàĮŹƙÕhǮ²ǊaËŧ¥laǱêŖòaÂ«¸Ǧ
3C2- 40 $R^&AML<AƓƑùć"þĘƮvîML<AƲưńĄƶǶīîÏǞŤ·ŢîǷǔħƙžaǰľadǐŀ¸aàūƢŢad©i¸
3C2- 41 ƞïǤ±¢ML<A"ŦBFK#&GbļƄƩǨǫǶīîÏǞŤ·ŢîǷÜÁƏǭaǰľad©i¸
3C2- 42† ML<ABFK#&GbĿƝ¢Ǝ±ML<A7/[bC`0ǶīîÏǞŤ·ŢîǷśŧĐĽaǰľad©i¸
3C2- 43* ŶǘML<A P[nǎƎġÎùƷƹǶīÏKOLaīÏ
ƁŸaJST  ǷĬǑÞŤaƠśŁõǙ æĪěòǶ14Ǹ40ǹ15Ǹ40Ƿ PCċƐğǛ14Ǹ30ǹ14Ǹ40 Ƕ4C1-35, 4C1-36, 4C1-37, 4C1-39,
4C1-40Ƿ
4C1- 35 PDMS ƫQ&/^[$/:b"Ŧ ATP Ëñ57>SǶô
éÏǞƁǷƅŧöĠaƥºlaĪeƪqaǳŧƀÒ
4C1- 36 üÿœ"ŦATP Ëñªă»ǚŮǶôéÏǞƁǷ
ƥºlaƅŧöĠaĪeƪqaǳŧƀÒ
4C1- 37*†ĉƉƷƵ?G&7"ŦǇ}Õƴė<=LǚŮǶīƽî
ÏǞŤ·a+5*ưƃĿǷūæĆcaŧhaś«ěÙaèǬ®aŇƺö°aħ¸ôaſŷűĕaĬňĞ
4C1- 39 K=Ƌ>^Qb¢±Ş8:2 FTOHŤƯ PFOAŤćǶīƽîÏǞŤ·aXCQ>=/ǷĘÄƆ®aŷtƪÕaĪŧŘc
Ǌaƥja¿tƂŅ¶aǅĝƙaĬňĞ
4C1- 40 8:2 FTOHzĤĘƮK=Ƌ>^Qb¢±ŞDTFAŤƯĄƶǶīƽîÏǞŤ·aXCQ>=/ǷŷtƪÕaĘÄƆ®aĪŧõǙ ĬǑÞŤǶ16Ǹ30ǹ17Ǹ20Ƿ
 PCċƐğǛ16Ǹ20ǹ16Ǹ30 Ƕ3C2-46, 3C2-47, 3C2-48, 3C2-49,-17-

3C2-50Ǽ
3C2- 46 ĸǗÇÅźoŮŁǋÔ×ŏǘƂi^ƙůĞô^ůgņ
8_5PPM1D ß dēďÄMJ:?
ĄǤÛǻÌǥŪǼīÞǦ^gǵ®Ǔ^ǘįåŭ^Â§µǮ
4C2- 30 #]HZ%]/$#Z2ĉķǤÛ KQ+Z:A]ƕ­Ą
M]8MJ:?¯×ǻĊÌŪñǼǺƩĦƚ^ı£ǈü^}ƩĦ
4C2- 31 ǩQZ-HU=Z#]HZ%]/KQ+Z:A]ƕ­ĄM]8='MJ:?ǕƶĳǻĊÌŪñǼë§Ìv^íůqƐ^ÌƲĈ^ı£ǈü^}ƩĦ

16ōÅ-K!G]MJ

4C2- 29 p53 ƺãĄN2H:?ǻİñÌǥŭ´ŪñǼǸ|ǧ`^ǷŇ^a£iµ3C2- 47 ǒzÒX#IXYǑđ33 =BO8]D*ǁ!
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Syahir^ÝîŊl^ļïśÍǓ^a£iµ3C2- 49 MJ:?![#ŮIgA Ơųǣe  Haemophilus
parainfluenzae ď£%G>_JĖƓǻ°ÌñǼĭůĦ¶^ĴÖņ^ÌŔƚÏ^ĬËưj
3C2- 50† MJ:?![#Ů ƝőǗǷƕ­MJ:?=/#]ǻ°ÌǥñǼƿ ĥ^Ľïŋ^ëc~^ƩƆ¬^ÌŔƚÏ^ǟì^ĬËưj

T="' ZC# &<*B \1_÷ǟ œůƍāǻ14Ǿ20ǿ15Ǿ20Ǽ
 PCėƖĢǢ14Ǿ10ǿ14Ǿ20 ǻ4C2-33, 4C2-35, 4C2-37, 4C2-38Ǽ
4C2- 33* ĜƳ0Z42)&).]ǽ(?YA$SǜMRI ŮǦĄǋýǡŴǻsÌǥñǼůg`ŭ^gùv^gĻ¸ņ
4C2- 35* ǖƒřĄţǁçÀ¯Ģş×Ÿĕ
multi-modal 19F
MRIJ\_IǡŴǻsÌǥñǼůg`ŭ^gùv^gĻ¸ņ
4C2- 37 ŭ¦ĂǊǆ Ëĸ NMR J\_IǡŴǻsÌñǼ
ǷŇſ`^ůg`ŭ^gĻ¸ņ
4C2- 38 ŭǷÒb@BĀƎÒǕţĄƹǻsÌǥñǼ
įČª^ůg`ŭ^hëęĪ^gĻ¸ņ

3Ĩ29ĝ¡MJ:?
÷ǟ ƩŨņǻ9Ǿ10 ǿ10Ǿ00Ǽ PCėƖĢǢ9Ǿ00ǿ9Ǿ10 ǻ4C2-02, 4C2-03, 4C2-04, 4C2-06Ǽ
4C2- 02 ǞǟǞ!Z)ZÅĔ!RBǗ­ČǻİŜÌñ^İŜÌƏǞñÓžǼǚīŌ^ǚīøj^ƃŘęƬ
4C2- 03 PZH"Y]ǌƕ!RBǗ­Č MJ:?ãǻƅ´ǴÌŪñǼŎƁÃĬĮ^¾ĵǍǪ
4C2- 04* ŬÈĂƊÄƫĄ!RBǗƺã²MJ:?­ČÓŶĄǁǻƛǵÌǥñǼŅæÁ¬ëůÁ`^®£ă^Ðśj^ǲůČª
4C2- 06 !7L]5]!RBǗƺãã
MJ:?ŁǋÿǻÌǥŪǼǝůūŕ^Úîõ^ǘįåŭ^gǵ®Ǔ^uïęğ^ƾǘÁĔ^Â§µǮ÷ǟ xƩºśǻ15Ǿ30ǿ16Ǿ10Ǽ PCėƖĢǢ15Ǿ20ǿ15Ǿ30 ǻ4C2-40, 4C2-42, 4C2-43Ǽ
4C2- 40* ƫńƽCPP-RBPshRNAƔƞãǒzÒŴũÿǻìëÌñǼǏƩŧņ^ÕčĞü^ÌŃǷª
4C2- 42 D_)]6A3SćǃÒ8_,;>ÒĖƓŸŶƶĄF&:]Y]'_ĩ Tetrahydroisoquinoline (TIQ)ƺãƸƷ­ČǻİŪÌƨǼƤéǀĆ^ĤëƜj^įŋ^ǭī
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4C2- 43 @B#]JY]>Y6+XH"_Ƿĉö#SBçÀƮǯ
JX3U]:;JǡŴǻƄŏÓñŀǼǂīƣĚ^ǷīŰƚ^ëĬ`¹^»ƾw^ïů¢ġ^ĽǪ^Žůġt^ópƜü^ǣØ÷ǟ Â§µǮǻ10Ǿ10ǿ11Ǿ10Ǽ PCėƖĢǢ10Ǿ00ǿ10Ǿ10 ǻ4C2-08, 4C2-09, 4C2-10, 4C2-11,
4C2-12, 4C2-13Ǽ
4C2- 08 E2:1]*X28_ÅĲã J\<!_5ÅǁƹǻkñÌǥŭ´ñǼǇhŻ°ĴůàÒ^Â¢ġ^ƩŨņ^Ġë·l^Ʋǘċµ4C2- 09 GM-Y]Ǘ²ĩ-X_,]U=ZMJ:?ŲòǡƯǻkñÌǥŭ´ñǼISLAM, Md. Nurul^SONU, R. Shanker^ƩŨņ^Ʋǘċµ4C2- 10 -2>X]?-KY;*2bǠŬT8402¦ĂǻkñÌǥŭ´ñǼïîǪaÌŽŹt^ƩŨņ^Ʋǘċµ4C2- 11 ŬťK).MJ:?ǬƄMJ:?@B:V_IŁƌǻkñÌǥŭ´ñǼ®îƢ^ĺ£ǰÒ^ƲǘċµƩŨņ
4C2- 12 Ô×KY;*2Łǋĩ żǞMJ:?ƫXLZ
ǻÝëÌǥƨǼļǘǫǃ^ƩĬµi^pbâü
4C2- 13 1!Y_Z%<]ǶĹĶŇżǞMJ:?-KY;*
2ÿǻÝÌǥƨǼŔ­¢µ^ƩĬµi^pbâü÷ǟ ÌŃǷªǻ16Ǿ20ǿ17Ǿ00Ǽ PCėƖĢǢ16Ǿ10ǿ16Ǿ20 ǻ4C2-45, 4C2-46, 4C2-47, 4C2-48Ǽ
4C2- 45 łÊǔŢŮ rĘ¦ĂC 60²ĩYP6_SƼƱǻÏƣƈÌǥţǁČǼǱŒùl^Ʃìº^œůƍā^ƧœƑ`
4C2- 46 YP6_SC70 ŏŠ ƘÓřĄƹǻÏƣƈÌǥţǁ^ÏƣƈÌǥC#&ǼŐǘƢ^¿pŰƐ^ƁëƦ^œůƍā^ƧœƑ`^äïĒ¶^ƉÜǎÎ
4C2- 47† fƴÑĄI\;*-PYQ_C60©Š ƘÓřĄƹǻÏƣƈÌǥţǁ^ÏƣƈÌǥC#&ǼƁëƦ^œůƍā^Ĝƾǧ^ƧœƑ`^äïĒ¶^ƉÜǎÎ^ëĬŹj
4C2- 48 ¼×ĎƭŮ ¥Ą#&]ǷÒƮǯ ǳǻŪžǼ
ŶÆm^ŉīƻ^i^xƩºś÷ǟ ƩĬµiǻ11Ǿ20ǿ12Ǿ00Ǽ PCėƖĢǢ11Ǿ10ǿ11Ǿ20 ǻ4C2-15, 4C2-16, 4C2-17, 4C2-18Ǽ
4C2- 15 Y;*2ŁǋĜƳňƟĄżǞMJ:?ǡŴǻW_^']/2ðÌǼµůģ^¿éÌ^¿éƜú^ğnľ
4C2- 16 \#0]1;D_ÄMJ:?9#Q_ûČMD ƷƋǻİñÌ^ǥŭ´Ūñ^H\]<"!ǼŇĬĒl^¨šÖô^ƀíÍǓ^ŉpØ^ìűąǪ
4C2- 17 DNA-1]*H"](_źoŮŮ Ǚ*X28_ơŰǕǻİŪÌŪǼĩÔŻl^Ƶpġ^ÂĬƣÍ^ëįÉ
4C2- 18 ÿ©ƟqǛH"](_MJ:?ǾŁǋDNAƕ­ÿǻŪžǼǘįƇÒ^ìĬģC5 yÆ
5 «Ǵ 5405 ĚÙŭňƟǣǌÓ^C#&<*B\1_3Ĩ26ĝ¡þǙê8] D*ǁ÷ǟ ëĬŗüǻ13Ǿ00ǿ14Ǿ00Ǽ PCėƖĢǢ12Ǿ50ǿ13Ǿ00 ǻ1C5-25, 1C5-27, 1C5-28, 1C5-29,
1C5-30Ǽ
1C5- 25* ÒǬƄÅŷā±
L_8KY;*2ŁǋǄÔ×tñƪŵǁŁǋŁƌǻ°ÌǥŪ^PRESTO^İñÌǥŭ´Ūñ^°Ìţǁ½ǨžǼŅpƐü^aŚ¤Ɛ^ǹŋ^ǅë¤ƚ^bǘǧª^Ǚh³¬^ĩÂěǪ^Şǉƥt
1C5- 27 L_8Y;*2ŁǋÅŷǙêFGY1]ǜǕÿǻ°ÌǥŪ^İñÌǥŭ´Ūñ^PRESTO^°Ìţǁ½ǨžǼ

3Ĩ29ĝ¡þ÷ǟ ¨šÖôǻ13Ǿ10ǿ14Ǿ10Ǽ PCėƖĢǢ13Ǿ00ǿ13Ǿ10 ǻ4C2-26, 4C2-28, 4C2-29, 4C2-30,
4C2-31Ǽ
4C2- 26* -#Z?-#ZŁǋŮ
8]D*ǁE?\,Z¼
×ǻİÌ^ŭžǼÙůµę^ÂĬŝā^ñƩ`Ɓ
4C2- 28 5ĬǞ-#Z?-#ZƪŵǁƸƷňƟƹǻ°ñÌǥñǼ

-18-aŝ­Ƥ^ńnƤă^ȟŊ^Ǣí­Ʈ^bǹȊ²^ǻg¹³^ĭÄĠȍ^Ťǥƾs
1C5- 28 ǩƪƇłĒP&+[F]ǡÚNXO_łơȢȆÐȉ÷ȣÐř³^¥ðàr^Ĺț²
1C5- 29 īéłǨ©Ǻ}R6]ŏǷ¤ǶƦÚǖǔ(1)Ȣq
ÐŉevV?9<^$AƏȣǈĺyÞ^nbȎĠ^ȡíǌ`^ŀnÜ
1C5- 30 īéłǨ©Ǻ}R6]ŏǷ¤ǶƦÚǖǔ(2)Ȣq
Ð$AƏȣȡíǌ`^nbȎĠ^ǈĺyÞ^ŀnÜ

3Ĭ27Ĥ¨6]D* ǟȢł ǨňƵ ȣÿȁ eƼǜ²Ȣ9ȥ00 ȧ9ȥ50 ȣ PCęƪħȃ8ȥ50ȧ9ȥ00 Ȣ2C5-01, 2C5-02, 2C5-03, 2C5-04,
2C5-05ȣ
2C5- 01 G*:^1L]+W_®ĉż6]D*ǟǳzųƁƇ
ȗŕȂƄȢĵÐȉŸȣ{įư^ŵ`ǲ^ƓŒe^Ň»Ó
2C5- 02† O"1ƶ/>J<4_Qż(]F$[_YƩ´6]D*ǟJ[:&_QǒĸȢĵÐȉŸȣµūÒǲ^Ň»Ó
2C5- 03 E<žĴCJ<+[F].IV?9<ƨĚźŻųĊŁǕȢĵǤ÷Ð÷ȣŚöƿÚÄnÒǲ^öĦĤș^ĥý³
2C5- 04 łǨčËÈƈ ȟƽI="ŷǄžĴǃƸ´ĒǊƅǟ
CapFňƵǒĸȢĵÐȉģȖÇȣãēÜ^ŽfƼ»^ȠŽǙ^ØȄ^Ťǰh^ÒŽĝÚ^Žf£^ŚıŞû
2C5- 05 \*8]ǍƉė ȟƽI="ŷǄŌƦĜÍ}ÚųĊǒĸȢĵÐ÷ȣǚfÚ^ŽfƼ»^fòĝª^ŚıŞûÿȁ ţŏǧȢ14ȥ10ȧ15ȥ00ȣ PCęƪħȃ14ȥ00ȧ14ȥ10 Ȣ1C5-32, 1C5-34, 1C5-35ȣ
1C5- 32* ǊƅǟƩĩƧÛƛȃż ǻìȏƙÌłơȢ·ÐŲǟÃȋƏ^·ÐȉŸȣǢí­Ʈ^öÌƊƮ^bǹȊ²^Ťǥƾs
1C5- 34 6]D*ǟƩĩfǻìƢÚźĒǬƘǑåȢ·ÐȉŸ^
PRESTO/JST^·ÐŲǟÃȋƏȣßǳŹČ^bǹȊ²^ßǳƲ^Ťǥƾs
1C5- 35* H#X8] ǽǷƦ¤ÝȦH#X8]ųĭǽǴzÚĄȢ&_*W]=ÚƃȉƏƚĔȣƂƺŋă^Theil, Elizabethÿȁ ŚıŞûȢ10ȥ00ȧ10ȥ50ȣ PCęƪħȃ9ȥ50ȧ10ȥ00 Ȣ2C5-07, 2C5-08, 2C5-09, 2C5-10,
2C5-11ȣ
2C5- 07 ÖŰĊŏƦƧǄžĴ/<*[Qc552 İƞX9*1ȃ
ȓȐƇƋl~ż6]D*ǟƜ}łǨßá¤ȢƠŖÐȉğŲ
Ųǟȣȝōƍs^őţ²^ÒǉĹ^abƍ`^œǹđ^ȁ­ǸƤ^íıŗă
2C5- 08 /<*[QcKQǦY_JłǨÍ¤ňƵȅȢƠŖÐȉğŲȣabƍ`^ÞŽöĈ^őţ²^țíƍ`^ÒǉĹ^œǹđ^ȁ­ǸƤ^íıŗă
2C5- 09 ÖŰĊŏƦƧǄžĴ/<*[Qc552ǳǫ¢xKQȐÚŴĐ7!>P*1ǒĸȢƠŖÐȉğŲȣőţ²^ǪǏ^œǹđ^țíƍ`^ïſČŸǅ^ȁ­ǸƤ^íıŗă
2C5- 10 C2æƗH9Ʀ¤KQłĒKQ6]D*ǟ  Fe-His ǴzƩ´19F NMRǒĸȢƠŖÐȉğŲŲǟȣŏȅ»¼^ãóŗġ^ļŽ­»^±úǀǝȁ­ǸƤ^œǹđ^íıŗă^Ǽįƕā
2C5- 11 In-cell NMR KS+[F]ÀǺ}ňƵǒĸŕłơȢƠŖÐȉğŲȣ{ǈĎĈ^ȁ­ǸƤ^œǹđ^íıŗăC.

ÿȁ õǢċȢ15ȥ10ȧ16ȥ00ȣ PCęƪħȃ15ȥ00ȧ15ȥ10 Ȣ1C5-38, 1C5-40, 1C5-41, 1C5-42ȣ
1C5- 38* ÀKQ/<*[Qc 3ȐÚĘ¯ĆÁÚȢȆÐǊƅƏ^ńÃÐ÷^ĀÐŸȣȈhŚƔȍ^țíǌź^éūŪ^éŀªĠ^Ń°ƾŅ
1C5- 40 ÍĊ/<*[Qc KQLJ8=İƞPBÈǴzƩ´ßáĊȢƠŖÐȉğŲŲǟȣÒǉĹ^ƴƨǉƳ^œǹđ^ȁ­ǸƤíıŗă
1C5- 41 '?žĴKS/?]ĊǟǷ¤ňƵȢȆúÐȉŸȣŭíoƤ^ǼįǞŔ^cö§ç^wĵć
1C5- 42 ǬǷ¤ŏƦȚ¢Å/<*[QP450BSǐŏĊ8TAYĄȢ·ÐȉŸȣǂ³ȁa^ǈÆǜ²^fòŘ^ĶŐ¡^Őǹƍ¸^Æâ¿^Ťǥƾsÿȁ Ĺț²Ȣ16ȥ10ȧ17ȥ00ȣ PCęƪħȃ16ȥ00ȧ16ȥ10 Ȣ1C5-44, 1C5-45, 1C5-46, 1C5-47,
1C5-48ȣ
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1C5-54ȣ
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1C5- 52 ǎĽ?9,YǶƦ"Z_3ǾŢ ǶƦňƵǣĚ
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1C5- 53 ŏȤ$6B_Yš´ŨÙfOY8Ǿ&)/7_3ǷƦȐŎ¤ÝƇǯ®ĉȢĵqǤ÷Ðȉ÷ȣ Ŕë`Ņ^ĳŽǞ`^fĳĪĠ^Ðǹāü
1C5- 54 /<*[QP450BSȔÑŬÈǟǓÙƇǷ¤®ĉ;!ÚłǨȅǩȢ·ÐȉŸ^ŸƏěƐƏSpring-8^qÐ"!Y1Ə^·ÐŲǟÃȋƏȣǈÆǜ²^ǂ³ȁa^fòŘ^ĶŐ¡^Őǹƍ¸^Æâ¿^Ťǥƾs

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2C5-31ȣ
2C5- 26 DY1ŴǡȕŖŮèX58_QśĊĆȢĵ÷Ð^ȉźºŸ÷^H[]: ȣǛŽƆÚ^öóƮ^îƀČȍ
2C5- 27 ǠÎŕÂ}ÈķbÂá¤ Calmodulin ňƵǘȢ¥ÐŸȉȣßǮȡă^ǹ°Ɣ^ȜóŞû
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2C5- 31 ďťĊS;YLJ8=(]OƬĻņ>BƢÚ¤ ǬƘȢȆþÐȉŸȣǈıƍŸ^±ŽȎ`^«Ŋi^ĳŽā^ïȃƌǭ^7]7IXU"V"X-19-÷ǰ é­ğŸȄ14Ȇ20ȇ15Ȇ20ȅ
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2C5- 33 7bD$Ê´cĴǯYH\`đ ĖcÔƿßȄǴËǵųȅéņĦùaŷīÏaĲgǹvaǮûŤuaÿƴ
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2C5- 38 ǥƝ !ŮųſŪ ÿļȄòsƎÖËȅŀ¨ÛaŭƐ

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3C5- 39† Żć «Ąǔǌ$ƀſ ģƾPYP ŽƯ½YC] ±Ů±ĎǄ}ȄǴËǵųȅêĴ ÍǡahĶtwaūŷłǸaĹśŸaêĶȃĦaéĴv
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3C5- 41 ŖĬŽėÔŚ$Ŷ\T<bWC&9O^'YG>\`2ȄĸðËaǵŴ¶ųðaM_`B&%ȅȀŷ¢ƔaȃŌÍǡa®
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3C5- 43* «ãQCM Ś! DNA U\X[b;«ĄÖǀĻȄĸðËaǵŴ¶ųðaM_`B&%ȅƃhǸcaïíƥańïŠÍǡaêŹĉǸ÷ǰ àîŐƍȄ16Ȇ30ȇ17Ȇ20ȅ
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2C5- 46 lǦPY7%G`%_9B\A1ļª þǿM
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2C5- 49 T-20ȄFuzeonȅƩćHIV-1ÈŻŁ !6-P\-]J`E]ŉǗXƤƠĬŉǗǀĻȄsËǵƳasË(&]9ƇȅŦǢŒaËƆƄkaƽïƺǏaŦǑ ÍǡahǨ§ĦahŝraËǨŠƔa
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3C5- 46*†\.`Eĕ³ÃDMAPǁÓ$ŶƟƫƭ^:O>bŊǉȄsËǵðȅ®ăŜcǡaSun, YediaƙÀƄkaşÀł
3C5- 48 ±ĎRO@EƟƫƭ%`-\`2!@_7`/Fb;72F\`2ĀȄĸËǵða ÖŴ¶ðÖâĝȅƧÄµóaƙÀƄkaǰŅǏƸ
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4C5- 26 ȀôÈ¾ć¦ƒƱūĲơ¾ć'6<Z3ËƺǶN@ǝß
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4C5-37Ȅ
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1C6-37, 1C6-38Ȅ
1C6- 33 N@ƍaǤī %T,ĸǝªčŹƁȃæǪÂïȄ
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1C6- 35 RNAĽũĸǝHWZGƼ(2) ]Ŧć>(V%/;<W)¯DNA ªč ćǌȃæǪÂïȄ^ǟƝl¦îń§YñÅ
1C6- 36 5-TZU/:/XßfİǤDNA IZ/7(:TFO ŶgwũȃĳïÂŧ°ŤïȄŇŪġÑYŭ¼œ[Ǡļ­YÂƂƄÙYǩĹǱYŔâöĄ
1C6- 37 6%&UAQ U»ÎŲ¶Ó
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1C6- 38 2-N-&UAQ U)=X3-N@ET50X¯%õǦ ƫ¸ǉúȃ15Ȇ20ȇ16Ȇ20Ȅ
 PCĔƖĤǨ15Ȇ10ȇ15Ȇ20 ȃ4C5-39, 4C5-41, 4C5-43, 4C5-44Ȅ
4C5- 39* ǳƪ2X-ZƶűǌF$::WEXŖôyÌŲ£ąȃjÂȄ`ĩĹŻmYňĂ\YĴçÂmYŵ¡[ĂYĂØ´YÛíŅŽ
4C5- 41*†ƐƪªčƒƱX8<ƎLH1 ƽªvĿǒüč&W8-21-Ĉ¯[Ļ£ùÕ

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2C6- 18 !WH8ZȇƣvƟª½1+Y;*3<VZªċ=U9,øǰ ŞåùĂȑ15Ȕ30ȕ16Ȕ30Ȓ
 PCĔƠĢǲ15Ȕ20ȕ15Ȕ30 ȑ1C6-40, 1C6-41, 1C6-42, 1C6-43,
1C6-44, 1C6-45Ȓ
1C6- 40 1VWÀáĚǈKVXZǍáv(V/ĶǤǀŀǐȑƦȊÊǶñȒuƿƈ[ļ§Ĩä[ƓÄ±Ì
1C6- 41 ǟrÏÉ½ĽŔđ­Ěǈ¦ȅ½@+X(1=ȇƣv® DNA ªċȑƦȊÊǶñȒƲj¥Ǚ[ļ§Ĩä[
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1C6- 42 ĶǤǀŀǐªŧ g1VWÀĐ ĚǈFXZǍávǱŹȑƦȊÊǶñȒĩǢàƳ[ļ§Ĩä[ƓÄ±Ì
1C6- 43 ŮũE3(3’-5’)2#A1ZǤ(c-di-IMP)ªċůŭŗĄȑ¬ÊǶĆÂƉÑȒ}¼|ǘ[ƿÔĝðƶÕ[Ƃ£ŲƼ[Ëűƥĥų
1C6- 44 C8 tƤĕ2’-;(*1,!A1ZǍávªċăŰȑĜÊñȒȐƿƧǻıĬĸü[^ţƇÊ[ǫȎĖ[Ȑƿť1C6- 45 3-!PAJZ6?<VW®ħǀĄ@+X(1= DNA ƝǛȑƦȊÊǶñȒðj¨[åîöğ[ĺ£ňǿ[ţjÕğ*TV!Ï ǋzȑǧ§ƃȒèAjÐ^ŚƺƘ[âűĉ´[ĩǢĊŒǡ
2C6- 19 Gd-DTPAƕÑȈĚǈMRIǜþªċ¤ǋzȑȀéÊȒǾīì[è`©[âðºo[åîsd[ĮèǼƗ[ōǧŐƪȉ[ě[ VALLURU, Krishna Reddy[ƿŏ^ų[Ƒ£ùǻ[Ǵ£ģŜ
2C6- 20 E3(7\FV2ZȒW:?$Q(II)Ǯv½ǌƾŰ ƕǔǨĳǉĳȑǴÊǶŭȒƵî¥ġ[qƿý¢[éįȋğ[è
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 PCĔƠĢǲ16Ȕ30ȕ16Ȕ40 ȑ1C6-47, 1C6-48, 1C6-49, 1C6-51,
1C6-52Ȓ
1C6- 47 !VWÀ}ǑŗŰ·žĎv_ DNAÑȈȑ¬ÊȒřœśe£ǻ][ǧ§Ȇ
1C6- 48 RY1!?ZƖƴƙá DNAŰ ĚǈǀIY\HǱŹȑ¬ÊȒuǧȉƸłű³[řœśe1C6- 49* µƋȇmñĶǤ DNAĿmñgǦǱŹȑÛèÊǶƾȒ¹jùö[ƽȂ²[j_àü
1C6- 51 ÏS\7\á(V/DNA ªċ ŅƯǋzȑİÊÉ ƃȒŎǒŽm[ĺ£|o[£ű×e[Ŏņ¨
1C6- 52 $U1WŊÀ5t&\:WǯƟª(V/@+X(8=ªċǩç#(ZƟªƯǋzȑƆÎðÊñȒĴÐĠ[éĬ
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 PCĔƠĢǲ13Ȕ20ȕ13Ȕ30 ȑ2C6-28, 2C6-29, 2C6-30, 2C6-31,
2C6-32Ȓ
2C6- 28† ƛƮx ƕǯU#HUV\(42)cĄƕǯůċŧǍá
CE-MS/MSŰ ǉĳȑĉÊŭñȒĭĄÓ[uƿĥ
2C6- 29 ƕǯIU#O\ŔŰ ƆƞƷưŹŬ ƕǯ LC-MS/MS B#3W\I9<ǉĳȑĉÊŭñȒǩÏĥ[Ê´É
Ƭ[cëƹǈ[ØðbĂõ[ŦĹŕÏ[Şő~ė[ƿĬƘ]ǡ[uƿĥ
2C6- 30 ƕǯIU#O\ŔŰ O$3ƭĄŸưƛƮF9ŹŬ ƕǯľǜēƚȑĉÊŭñȒâƒ£ä[Ê´ÉƬ[cëƹǈ[ØðbĂõ[ŦĹŕÏ[Şő~ė[ƿĬƘ]ǡ[uƿĥ
2C6- 31 ƕǯȈǨÏ=9<Ű ƛƮĶƊǂǉĳȑÊȒǳ§ƨË[ǆåí[ĚǏ][ıå}Ð[æ¾ǠŒ
2C6- 32 ƕǯȋÏŰ !PY#=ǽǵÙǅȑǷƐÊȒǪîÊǘ[ōǧ[^ŚyÏøǰ æ¾ǠŒȑ14Ȕ30ȕ15Ȕ20Ȓ
 PCĔƠĢǲ14Ȕ20ȕ14Ȕ30 ȑ2C6-34, 2C6-35, 2C6-36, 2C6-37,
2C6-38Ȓ
2C6- 34 ÀĲǃȁ_Gb3ƕǯJYŋƙžhxŰǉĳȑ1ȒƕǯÚ÷ĵȑİñÊ[Ƕů°ŭñ[GYZ:"!Ȓļ|ğ[ÊÄǞǡ[ŞōúŃ[éŵąǻ2C6- 35 ÀĲǃȁ_Gb3ƕǯJYŋƙžhxŰǉĳȑ2Ȓƕǯ
+U37\ĵȑİñÊ[Ƕů°ŭñ[GYZ:"!ȒÊÄǞǡ[ŞōúŃ[ļ|ğ[éŵąǻ2C6- 36 ōĤŹĒÏ_.Z=Y#8ZNVRU\5ȑİñÊǶů°ŭñ[ćƁÊÏƉÑƃƹĘƃƌȒâÝǓe[ĮŚ~Ì[īúŒ[ļ|ğ[éŵąǻ2C6- 37 óãƕD-7)<\3¤ D-!UEA\3 XƢľǜǉĳȑȉ
ðÊơªů°ƉÑƃƌ4ȒşǢ¨[ŉűƩģ[ĬǄǘ[ƂjƁü[wļ[«űǄƥ[ƆȌċú2C6- 38 ǕƱŴŘvc&U3<O\ÀĲůvȋÏ·ÖȑİñÊ[Ƕů°ŭñ[GYZ:"!Ȓęĉƅ[ļ|ğ[éŵąǻøǰ Čǒó]ǡȑ9Ȕ00 ȕ10Ȕ00Ȓ PCĔƠĢǲ8Ȕ50ȕ9Ȕ00 ȑ2C6-01, 2C6-02, 2C6-03, 2C6-04,
2C6-05Ȓ
2C6- 01 ǁŶƕ®ƕǗƊǣƙǵÙǱŹȑİñÊǶů°ŭñȒ^ńsǂ[šřƹ²2C6- 02† ƕ1-MUAL3G%\<Ű ƕ1-VZǤǍávªċŔȑİÊǶĚȄ¿Ȓıį¨Ï[éÈÍ[±űŪ2C6- 03 gǦǯĶǤƟªƯħ Ěǈ(V/2!PAƕªċȑİÊǶĚȄ¿Ȓ±űŪêűËĪ[ȃƿƀ¨[ǰƿË
2C6- 04 O-OZA\3½ƕKI8=ūŻªċŔŅƯǉĳǳƃƌȑÊǶů°ƉÑȒǖĥǥȉ[ŌƯŕ[iïõË[ǆįƜ]ǡ
2C6- 05* +U-čĚǈQ8Zȑŭƃ[~±ñȒaű
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 PCĔƠĢǲ15Ȕ20ȕ15Ȕ30 ȑ2C6-40, 2C6-41, 2C6-42, 2C6-43,
2C6-44Ȓ
2C6- 40 In situ>AIY\HŰ RNA ǉĳȑİÊ[ñ[C#(&Z2ȓİÊ>AC#(ďŤȒ«űċß[ī£ǹ[cį¨[^Òŝ
2C6- 41 kǭ#(ZĽX1(ŠÖǀIY\HǱŹȑǴÊǶñȒ
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2C6- 42 IY:!\5ŗĄĽ ǰß°ǀÇÊ½ó¹ȇIY\HȑǴÊǶñȒİ]¡[ō_ǝ[ǩÏàÜ[ƻ»±f
2C6- 43 IY:!\5ŗĄĽŰ19F MRI IY\HǱŹȑǴÊǶ
ñȒŢðy[ō_ǝ[Į£Ęā[źðĞÕ[ƻ»±f
2C6- 44* ǬƄȏ+U37ħ ?<Y->\5ǗŗĄ¶Ï VnfA+U37ÿȑ¬ÊǶŭ[¬Êŧǔ¸Ǻ4Z7\Ȓcëŕ[ȋǒ~e[şǚƶm[ǾǧǦøǰ Ļ£ùÕȑ10Ȕ10ȕ11Ȕ10Ȓ PCĔƠĢǲ10Ȕ00ȕ10Ȕ10 ȑ2C6-08, 2C6-10, 2C6-12Ȓ
2C6- 08* Ï+U$;"Z,ŮÆ N-Ɵª½ƕ7ZD+ǔIY4
1Z,ǣƙĄũȑŭƃ[±ŇèſƎƉÊ[CREST-JSTȒČǒó]ǡ[j£Ƨm[ıå]ǡ[qƿõċ2C6- 10*†UDP-,W.\3ǍávŰ ƕ7ZD+ǔG'\W;"Z,4Z0\UGGT ÀǔŨŷĄǉĳȑŭƃȒØðŝ[Čǒó]ǡ[ıå]ǡ[qƿõċ2C6- 12* 19F NMRƕǯIY\HX+8ZžhxŰǉĳȑŭ
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 PCĔƠĢǲ11Ȕ10ȕ11Ȕ20 ȑ2C6-15, 2C6-17, 2C6-18, 2C6-19,
2C6-20Ȓ
2C6- 15* Ɣ{ƕKI8=ªċŔǱŹȑŁòÊǶȒéĬl[žȊ-22-ȒķǩíÉǿíȓġǆƩsÐXžfŖÐXâǠȊXĸèƽħ

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3C6-29, 3C6-30ȓ
3C6- 25 RWƴǢ.NW9F-'S^PCR  DNA ÅñȒķÉǿƨ©XķgŸÉǅȓžĶƩĉÐXĬçƫaXôžƮZǱX
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3C6- 26 ƏÁǲNMRŚē5-CS#U Q-Sƥ©Ƿ ÁÙǷǖŨȒÏǥŴÉǅȓèĶĉƩÐXªeƛǉ
3C6- 27 #R+='T#5:Ð$E1SnĜāȒÍƺ~ƘÉǿűǢȓƍìȁÉXpĲ²ŠXņǙéȁXǃŕƢZXňç
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3C6- 28 RH2YKƶ\ ǮĔƇÐǚǞŽģǐƶǈ©
ƠǗǖȒĥÉŻżíȓ»eƾÍXĽžōXĸžťƩ
3C6- 29 ȃƀļ8@/Ž ƴǢƶȃǁŃ ȒűĵŇńȓŰèƌōXe\ǌƩXºžûXĸ|hXÚǌc
3C6- 30 RWƴǢcÐƶ ÐǽƊdrŽ NOE ǓŨȖF'S,0ļŧõļȒgÉƎȓģǟĉXªžyXĸĻ
oóX^öǻ ġǆƩsÐȒ10Ȗ10ȗ11Ȗ10ȓ PCĚƦīǽ10Ȗ00ȗ10Ȗ10 Ȓ4C6-08, 4C6-10, 4C6-12, 4C6-13ȓ
4C6- 08* œţ1,246mĘŵţšćÒ©ďŻű-W$B@R%ƄƤƲ LPS ŬƄąƚȒšŞƎƗǼƆŇńȓ
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4C6- 10* ƤƲuǫƳİ ģǐȏŇƳƤƲÇI9R'/3WA'ǢńƜȒķíÉǿŻ®Ÿíȓ^ĶƋïÐX[ǵŋ¯X^ĶƋiXáƂƽŸ
4C6- 12 9QW/-/EQ-W(ŽRNAŃ ƠǼƆȒķí
ÉǿŻ®Ÿíȓ¶eÕȁX[ǵŋ¯XáƂƽŸ
4C6- 13 ƏćĂƞÐŽ
ŢũĜǪ8@/1ƤƲǯnÐǕĺąŽȒ«ÉǿíȓÉŗƩÍX·æǌƫXùžØXĴÈǌaöǻ áƂƽŸȒ11Ȗ20ȗ12Ȗ20ȓ
 PCĚƦīǽ11Ȗ10ȗ11Ȗ20 Ȓ4C6-15, 4C6-16, 4C6-17, 4C6-18,
4C6-19ȓ
4C6- 15 ȏŶƤƲĘė8@/Ž fluorescence in situ hybridization
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4C6- 16 )?K>69VY'ǕĺđǊǾ ¾ƈđǊĠzȒķÉ
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4C6- 17 ZƤƲīƠǕĺŽ ƤƲųčĒěȒķÉǿíȓǋž¯îXǆžư§X[ÔŤ
4C6- 18 DNA $5#WćGE5:ƤƲǓÝȒ«ÉǿíȓǽłĨX¹ƛXŦĎŉÒXȎÁ³v
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ǡ_hľ|_ê²aē3PA- 036 G"]2^șDNA I6P`B$2^-`<]^E^ȑŚ¡ØőȣýƊƛÎȉòȤůǫæƆ¯_hľ|_ê²aē
3PA- 037 FZQ0^7P`ȘƳ´ DNA PCR Ì÷ȣ¢ȊƝÎP:Z[_JSTIY.ƎñȤǅǺȎk_ǋĻǮ
3PA- 038 DNAY*`/X^ RNAĺƝYKZ^(ȣ¢ȊƝÎP:Z[_JSTIY.ƎñȤǅǺȎk_ǋĻǮ
3PA- 039 mĻȁRNA :^I\`<F\^JZ%[\ȣýƊƛÎȉòȤľcȋù_°Ļīµ_hľ|_ê²aē3PA- 040 F\^Ǎſ RNA ƇœǮǘłȣýƊƛÎȉ
òȤ°Ļīµ_ľcȋù_hľ|_ê²aē3PA- 041 ħǖǍǟåǲ{ÖőȣŻƏȤxǋƷț_Ĕƀ
Ȏl_ŇƀƲ_­ñ¸â_ǭǋǑÖ_ȈǵŤ_ŉƀÐ_xǋ¿
ũ3PA- 042 )`0=RNA¯ēſÊÆǵ O6}MeNP Æå (A/^M1M]Q7<¯ēMeNP ÆĦ«ċȣöqƖØÎŽ·żËȤìŲƑÖ_ÎƞĳÖ
3PA- 043 DNAmǹȁăēſ %8$^ČǃƬz¯Ǡǒȣ²ÎȤŕƀ»xǋňƫ_ŦŢũk
3PA- 044 5K^3^å ċƠČRNARNAøŮąȕ
ȣ²ÎȤxǋũ_ŎƿÁ_ŦŢũk
3PA- 045 ǷŸƄƇ']1Z^'«ċſ ȝĐüǲ{ÖǜĦţȃƅȣ¢ȊƝÎP:Z[_JSTIY.ƎñȤxǋ¹_°ľ
¿Ŝ_ƱǑ_ǋĻǮ
3PA- 046† DNA S8[¡/</^ÊÆȑŚ¡ØƇőţȣqÎȉòȤêƀj¾_ƀǳat_ǔĻŭa
3PA- 047 ħǖǼéEFZ0[ș sòŋǸ¯ē œǮőǛȣȆÎžƏȤ¶ÎĠ_hǣ¸Ą3PA- 048 ǼéȀƮ¯$Z,@'\$8=ƧRNA ĦœǮťČƈȅȣȆôÎȤ³¬Î½
3PA- 049 4G<ǼéǷ}ÖĚ sò DNA ǼéȀÅÊÆäă
ēȣĿÎȉŻ_²ÎȉŻȤƞşĎ_ƀhÏǴ_ÊǣĄ
3PA- 050 bǹȁăēİHoogsteen ÊÆäÛÝ¡ħǖsòÊÆ
ēǝȣĿòÎȉŽ·Żò/ĿòÎG]^:Ǯ/CRESTȤ

-27-

śriúnÆ½i²Ĕé
BfW&b6=h\AdTQ=Cƈ v#(hƕwƊȽǴÝƅāitāÝĝÔāȾȸƋƗåiȖƋǆ¼iƋǜƿiûçviƂŬĬ
3PA- 076 TQ;#VjdȮŎȀŨĚƕșǉǶǊƕwƊȽǴÝƅāȾ~ŀƳåiąȫkiȖƋǆ¼i¢ǗðŜȢiƂŬĬ
3PA- 077 LBHUWE1 mUBA C[#h`M+=h;hKǶȘƕwƊȽŏĂÝȝiƅƙ GSCȾ«Ìȴ}iÝǲǞsiČƋ
Ŧ
3PA- 078 ŽǚŰ!dPYhæÊn6=dShǫô ƏĚªĥ¦ȽȚÝȝƅȾÜƋåúºŬȦi´ƋĬ
3PA- 079 Ģ ƺ¾ȉ¸ǻ Od(e7#hƀƏſƅƒĥ¦ȽȚÝȝƅȾƧpë{iúºŬȦi´ƋĬ
3PA- 080† ;hK-ǶŎȀo!d,Eh¤ŅȽŀÝȝĩȭÏȾāǗÐĕilÒȹƅåiƋpǌÃiŧĺŬą
3PA- 081 1H-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase ŎȀêìĚ
ȽY_h6;jÝȾƝú¬iGuddorf, JessicaiAlbers, Alexanderi
Fetzner, SusanneiHinz, Hans-Jurgen
3PA- 082 ĵŒõåĘƩ\5_jdC[#hǨǦȽÀāÝȝāȾŘǗȠ¼iȖǱĀ®ÙiŝȏơriƿƋīĆiƋpŐ
3PA- 083 -4-fA+6BchǙǍƵǠ¾ª
GFP ØƏ
ǨǦ¯¾ĠȽŀÝƈƉƙȾÌĺŰėiāǗkƟ
3PA- 084 TQ=CģƴɁd@E$Zȓ 0!  ƐĚ{āǘƑǶ¾ĠƶǇôĥ¦Ƚ«ȍÝȝƅȾȶĻƜui~ǗȃđiõòǁƍiƋęǦiÝƘǐȈiƘƋĨ
3PA- 085 ȅåǽȄpH ĘƩĚWcTQ=C )dV+4[=
dªWcL6=5hŒǈǩȽȱȊÝȝȊĂƇÖȾȬǗǀƌƱiķ
úƥkȈiȖûĮviĀmŬǌ
3PA- 086 S4-dŝŵŮpWcTQ=C0hU[j4ahȽtƉÝāȾƝøđilȚĈÝiĕrąiƮƔė
3PA- 087 Ȩŝŵäư!YHȌ¦ƒǿĉȽúĐÝȝƅāȾƨ´ȆkàǌŘ|iÝōȼÞiÝǱŖiţÛěåiĸýȼĶ
3PA- 088 ǶȐŃŤƊ BfhMhȿc*hCTQ=CƕwƊŌȽƅƙ GSCȾíåiƘyǳĈiČƋŦ
3PA- 089 LCɀMS ĴƸƯªƉſƭĭìȐŤȽȚÝȝƅȾ«ľĬĪȲiŁyçÞiŗĸĦkiŁŋĬiÝƘĖiľƋȃȢiƕ
ĺlȈȏŖğ¿ûiŰøċėișŉȢ
3PA- 051 2 =(=Y5h8 =(+9A(+4!AH4hÁ(c1F-e(=C¾ĠlȎȕĐĠǈȽŀāÝȾÝƣƥñȷńiíƋkiûĺiƋºıđiŰøċėișŉȢ
3PA- 052 lȎȕĐĠįHoogsteenÕÐóêìª uric acid riboside ĠǩȽŀāÝȝƈÂƅāȾȏŖğiŰøċėișŉ
Ȣ
3PA- 053 2’-O-)dJ\#d!AH4hÁ(c1F-e(=C¾
ĠÕÐóĐĠǈǩȽŀāÝȾǢŘė~¨ǀŠåiÝƣƥ
ñișŉȢiŰøċė
3PA- 054 F-e(4CN-(+4C5’-BcchȌ¾ĠȋƵ¶ĘÐǶƀƏĚȽŀāÝȝƈÂƅā/CRESTȾǤƋŬāǗĳǀiÝ
ƣƥñiŰøċėișŉȢ
3PA- 055 3’-(jJjIh.ȉ!YCƺ¾ÍRNA Ȱ
siRNAňȌǥȋƵǃĚȽăzƠèÝȝƅāȾüŹƛåȻĀļà
3PA- 056 DNAWc[bj8chȌȉȰÍF-e(=CȕȖ¶ĘŌǧȽƅƙiǑŝáÝȾǼǗǞåiȜȉŦiƃ
ƆiġƋȣuiƕĀzåiŁĺ©Ři~ǗÉŬ
3PA- 057 4-(+9HGDjdÐôȰňȌ¾ĠǩȽzāƾÝȝāǏƠèȾõÒÅƈõŲÈiú¿ȹåiľmƥ
3PA- 058 5-[=d4B4h=YhªèƒØƏôŤȗƐȽ«ȞƦÝX@c!diJST Qb3ƘĀȾ¿ľÉŞiŁľǳ×i
ǗĺȀ
3PA- 059 2’!:jdƇĵ $c5hǫô ¾ĠȽƝàĀÝāȾúĎiûĺiõȏĲ
3PA- 060 ¶ĘĚňȌÕÐƹǻĩǣTQ=CňȌ¾Ġ ŒǈǩȽŀ«ÝiÛƙȾČŷĳÄiĔǗƖiyĺąiŞŔ¼
3PA- 061 Development of oligo-DNA coupled micro columns for isolation anddetection of DNA oligomersȽzÝ&GƙȾ)Y7@"D/hCbXjdiƑ§ďiȏĀŴiAJb^!Kc)X4%^=]cdiÃƋÆƍiõŸ£ižȏËƜ
3PA- 062 DNADHŎȀ Ɗ;hK-ǶDH!e#ȗƐȽŀÝƦƙȾŢ÷ÞȈiǔǱĬƱiõíúƖ

3PA- 075 ÛȐ;hK- Ƕiȋ Ƶ
3PA- 063 vȐªFPR!h;1E6B¾ĠLBâpƄƊȽǴÝƅāiǴÝ­ȾŇƋÝ}iĻúÝǺiȖƋǆ¼iǗƋkȈiŪ
ÿȢąƂŬĬ
3PA- 064 GPCR Í¹ï ǊǲǾTQ=C¾ĠâpƄŨĚªȽǴÝƅāiǴÝ­ȾĻúÝǺiŇƋÝ}iȖƋǆ¼iǗƋkȈi
ŪÿȢąiƂŬĬ
3PA- 065 ȺǍPC$ƄǓƌĿǘƑǶRZ¹ų ŒŎǥŃȽŀÝȝĩȭÏȾêȉǌÞiƋpǌÃiŧĺŬą
3PA- 066 LBY(.fMhkȌªȌƵȂȌªŝƵ¶Ę46@#hŚÐēȪȽàǌƦÝſǶ ĠȾũǢƅiȖ
øǅiČƋ
3PA- 067 Ƿâż»ƶǓPyrococcus furiosusƌĿPI-PfuI#h@#hȶŒǈªƓĤ
7e-4ahŤƚƤȽÀāÝȝāȾǒ´ÝişƋñsiŝȏơriƋpŐ
3PA- 068 ǙĚ!h;1E6BƊ CXCR4 #[j5h.țî6-cjEh.ŤƚƤȽŀz­řÝƈĽƙȾƋȉťƥiȏ
ľűiÓŬiƋpĳ³iÝĊǵviȳȏůiúĺƔŐiǗyçiƂľÆÃ
3PA- 069 ;hK-ǶǙ#[j5h.Ɠƒ
TQ=C?jdȽŀz­řÝƈĽƙȾÓŬiƋȉťƥiȜȉŰkĶiǕµĬiÝő²ǀiƋpĳ³iȏľűiƂľÆÃ
3PA- 070 ȺǍPC$ƄǓƌĿǊǝȩǘƑǶ EbpS ŎȀiſĚǥŃ
ȽŀÝȝĩȭÏȾpĸġǭiƋpǌÃiŧĺŬą
3PA- 071 Poly(N-isopropylacrylamide-co-acrylic acid)ƊØĚȇ
LysozymecO'jdA"h.ȽĪÝƈƉāȾǹȉğÞȈiȶőÝ
ǺiÃţ
3PA- 072 DNA Ȱ
O%c=hƊ ȶŔŎȀŎƬ
ȽJSTCRESTȾpĀ³ȃiúnkȈ
3PA- 073 TET ;hK-Ƕ DNA ŎȀǪǰŒŎǥĬȽȧûÝƅȾȶŷǮÞĶiÇƲ|iÝ¿þħ
3PA- 074 ¾ĠƶǓ!h@Dư;hK-Ƕ/ǍƵǠ¾ ÐłmƹƿªȽÀāÝȾĔǗiœyĳđiƎćƍiȯƋŬ¼iǂƯ
3PA- 090 ǯŶpŕ3PA- 091 ĹƦ-*b-B4dÐĵ=(jdÍƯǉǶ¾Ġ
ȽƉƼƙƈſŒǈāèȾľmĜkiǗƽiǎmÐĠ
3PA- 092 54f+2hÍņőŎȀÁxźƯǦƪªèƒŌǧȽƉƼƙƈſŒǈāèȾ»šŰç
3PA- 093 ƯȕŒǈG>Bgj-Aj;Sj6“ Glyco-Net”·ȔƯȕșȁƊǬȡùªȽ«ÝȝƈÂƠèi«ŭȃSTSȾlūĬĈŹÃåiǗ°iÎǱħƥiƞýčiǡľƷkȈ
3PA- 094† ĩǣH#bYE<j8țî¾ĠƙƢ(V):=(4!f(c1Ư¾Ġ-b6;jªȽÑƂÝȝƅāȾÌĺƳkiõúÅßi
ĄȏiŻŢÝȟiȒĸċßiŁûŬ½
3PA- 095 .c02YH.c)h\AdȶåƊ !Yf#CȤțî ǟȽ«ȞƦÝȾŝȏiȑÿÝǺilūå
3PA- 096 !YH.c04Cǫô ¾ĠĩǣĢƈſǶǨǦȽ«ȞƦÝȾƨǱöčiǋġĆ½ilūå
3PA- 097 Ưȕ!e#Ɗ !Yf#CƕwƊǥŃȽ«ȞƦÝȾlūåiŁĺƻȍqiƞƋƗ³

ǉǶiƈ

ǊiƶǇ

3PA- 098 5-Od(f$b4dǉǶǊƕwƊșå¦¡
è4Y_ej4ahƙƢȽãǸƁ±ÝǖȾ¿yƫǛiûľě
ǀå
3PA- 099 8-+HcEd6dUhȌ&6@dȵŊ ǥĚcW
9jZǨǦ¾ĠȽŀƅÝǖiŀƅÝDDSƙƢ7ȾmĀĒi«ľŖiİúǁsiȥĸ
3PA- 100 chǉǶŎȀæǊõǇ¦ĞȽ«ȞƦÝX@c!
dȾĀºǄąiƘykiŷƋ¥iȶĸīë
3PA- 101 ƶǓÚǊǉǶcNCAĢǓTQ=Cƺ¾
Ǌ
ŒǈØªȽƉƼƙċāèƙƢ7iVj6@dƙƢ7h;jȾƞû-28-ĮLHOWE, JoergLANDRAE, JoergLBRANDENBURG, Klaus
3PA- 102 Ŭ£Ğ2 sĲHA+MDßĤŸ|ŦmĢB1HIŹ¦ÛbľLOîŧLúĆzLŶÖË
3PA- 103 ņ÷Sã3PA- 104 B#J:-MK{=0ħAHC4ĲPĄcĩīdĽŸųŖťŖ°ĂŹŌŕy±LåċŢĖLŠªÏXL­PïĴLŞÖÏ
3PA- 105 B#J:-MK{=0ħAHC4Ĳą Ĩİ/0>dĽŸųŖťŖ°ĂŹŌŕy±LåċŢĖL©Q[ĸĥLŠªÏXL­PïĴLŞÖÏLÛŜĐ¼

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3PA- 106 HKřĪ ÀAHBM9 CE10#)K&K$
Ÿ´«°mĢĚŹŵŕÈÁLŝ ġn
3PA- 107 ŠÕiıčn½Ąþ{/0> K%3Óâ
éùŁôŸĒĠ´«ĄĂŹţtÈLöÌ
3PA- 108 ĨİÆĔâıÓ )K%B3H0#(šč łgŸU®ŹĆ7PĘŚLò­ŪLÅĠoŋLêŜÂVLÎ©V
3PA- 109 =J)KjűNADą Bacillus sp. B29ćÙ,ŒlŘħĵħsĿłgŸ©¹ťā®ŹÖ«ŷÔóœļLëÁ
LZhº3PA- 110 9 %M?GK(ďĎ ]®ŘħĲ Ã}¥c)K%29({ŸU®ŹĆSÑVLĆĭL§ģNÃLêŜÂVLÎ©V
3PA- 111 B#J)K%ą ČĨİqìÀřħğūæ{ĎôŸÚāā®Źę­j²LĆĐ¸LØĆķuLõíē
3PA- 112 Řħ¿ąC7řĻnsÜŸ´«°mĢĚLª©
®Ź¦~ŴLàŶLŝ ġn
3PA- 113 s{"FH 84J=<KĊŭÿÀł
gŸU®ŹĆ~ĈVLSŏÞeL LINDER, MarkusLò­ŪLêŜÂVLÎ©V

E2! I9

1#7 J'M LĄc ŀ ¿3PA- 114 (1J4sĪ Ŷs=ID ÃŸÊÈāŹŶŜśèL¦­ěXŔLŰĆŨLĶà¶ũ
3PA- 115  KñcSŘħ¿Ż=0ħAI=HKH:M*ŀŎµŅĎnsxŸª©ťĳûĝŹfŵäįĕ¸LÐèÇ`LŗZň¾
3PA- 116 .M# :MIL9'I(M3L9'IŲĨİ1ź=6I-7MIŮĠcŐÄĎř{¿ŸÊā®Ź^ĺŉNLSØĹLŗ¯¸LÒ~ňnLqÏ
3PA- 117 H:M*ą $H)JMIŃ¥cRÉŬ£Ğ{ŸŴ­ōŹę¤T¦ÝĬ³L­ð¶¸
3PA- 118 jű-&#J2"(3HKprĪWýH:M*ą XĦçř ;4J"&I"I=6I@(=K "&4nsxŸĜªāŹPĆ¨»LükŔLŊ³Ą
3PA- 119 LIM"5M*Ť¡w ÃłgđYdąĿÜŸÚ|ťĄĝŹ­Ū]Lá×\LaÖńLOăLáNäLçŜkd3PA- 120 ő_?#-MąĐşĀÍpPEGMA-b-pDMAEMA ÃþÀłgŸĴmĢŹS­¤L·~¾iLĺvL¢«¬ėLø×nĉLŇ~ä

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