2023/9/20

Publication
150. Terada-Hirashima J, Takamatsu Y, Shimizu Y, Uemura Y, Takeuchi JS, Tomita N, Matsuda K,
Maeda K, Yamamoto S, Fukunaga A, Ohmagari N, Mikami A, Sonoda K, Ujiie M, Mitsuya H,
Sugiura W. Immunogenicity and safety of single booster dose of KD-414 inactivated COVID-19
vaccine in adults: An open-label, single-center, non-randomized, controlled study in Japan. Hum
Vaccin Immunother. 2023 Dec 31;19(1):2193074. doi: 10.1080/21645515.2023.2193074. Epub
2023 Apr 13. PMID: 37052247; PMCID: PMC10114994.
149. Nobori Y, Anraku M, Yamauchi Y, Mun M, Yoshino I, Nakajima J, Ikeda N, Matsuguma H, Iwata T,
Shintani Y, Nakayama M, Oyama T, Chida M, Kuroda H, Hashimoto H, Azuma Y, Funai K, Endoh
M, Uemura Y, Kawamura M. Risk-adjusted hazard analysis of survival after pulmonary
metastasectomy for uterine malignancies in 319 cases. JTCVS Open. 2023 Jan 30;13:411-422. doi:
10.1016/j.xjon.2023.01.014. PMID: 37063124; PMCID: PMC10091388.
148. Takaki T, Chujo D, Kurokawa T, Kawabe A, Takahashi N, Ito K, Maruyama K, Inagaki F, Shinohara
K, Ajima K, Yamashita Y, Kajio H, Yanase M, Hinohara C, Tokuhara M, Uemura Y, Edamoto Y,
Takemura N, Kokudo N, Matsumoto S, Shimoda M. Quality of life after total pancreatectomy with
islet autotransplantation for chronic pancreatitis in Japan. Islets. 2023 Dec 31;15(1):2202092. doi:
10.1080/19382014.2023.2202092. PMID: 37087752; PMCID: PMC10124982.
147. Mitsui J, Matsukawa T, Uemura Y, Kawahara T, Chikada A, Porto KJL, Naruse H, Tanaka M, Ishiura
H, Toda T, Kuzuyama H, Hirano M, Wada I, Ga T, Moritoyo T, Takahashi Y, Mizusawa H, Ishikawa
K, Yokota T, Kuwabara S, Sawamoto N, Takahashi R, Abe K, Ishihara T, Onodera O, Matsuse D,
Yamasaki R, Kira JI, Katsuno M, Hanajima R, Ogata K, Takashima H, Matsushima M, Yabe I, Sasaki
H, Tsuji S. High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre,
randomised, double-blinded, placebo-controlled phase 2 trial. EClinicalMedicine. 2023 Apr
14;59:101920. doi: 10.1016/j.eclinm.2023.101920. PMID: 37256098; PMCID: PMC10225719.
146. Ishiguro C, Mimura W, Uemura Y, Maeda M, Murata F, Fukuda H. Multiregional Population-Based
Cohort Study for Evaluation of the Association Between Herpes Zoster and mRNA Vaccinations for
Severe Acute Respiratory Syndrome Coronavirus-2: The VENUS Study. Open Forum Infect Dis.
2023 May 18;10(7):ofad274. doi: 10.1093/ofid/ofad274. PMID: 37404955; PMCID: PMC10316690.
145. Suzuki Y, Iwamoto T, Uno M, Hatono M, Kajiwara Y, Takahashi Y, Kochi M, Shien T, Kikawa Y,
Uemura Y, Hagiwara Y, Yamamoto S, Taira N, Doihara H, Toyooka S. Development and validationof a symptom illustration scale from the patient-reported outcome common terminology criteria foradverse events for patients with breast cancer. Breast Cancer. 2023 Sep;30(5):856-868. doi:
10.1007/s12282-023-01480-3. Epub 2023 Jul 8. PMID: 37422608.
144. Tomita N, Terada-Hirashima J, Uemura Y, Shimizu Y, Iwasaki H, Yano R, Suzuki T, Saito S,
Okumura N, Sugiura W, Ohmagari N, Ujiie M. An open-label, non-randomized study investigatingthe safety and efficacy of smallpox vaccine, LC16, as post-exposure prophylaxis for mpox. Hum
Vaccin Immunother. 2023 Aug 1;19(2):2242219. doi: 10.1080/21645515.2023.2242219. PMID:
37559375; PMCID: PMC10416734.
143. Yano R, Terada-Hirashima J, Uemura Y, Tomita N, Shimizu Y, Iwasaki H, Okumura N, Suzuki T,
Saito S, Ujiie M, Sugiura W, Ohmagari N. Efficacy and Safety of the Smallpox Vaccine for
Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study. JMIRRes Protoc. 2023 Aug 25;12:e46955. doi: 10.2196/46955. PMID: 37624623; PMCID:
PMC10492167.
142. Takeda Y, Naka G, Katsuya Y, Kobayashi K, Suzuki M, Hashimoto M, Hirano S, Uemura Y.
Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide
polymorphisms: a prospective observational study. BMC Cancer. 2023 Aug 26;23(1):800. doi:
10.1186/s12885-023-11257-8. PMID: 37633908; PMCID: PMC10464354.
141. Takumoto Y, Shiroiwa T, Shimozuma K, Iwata H, Takahashi M, Baba S, Kobayashi K, Hagiwara Y,
Kawahara T, Uemura Y, Mukai H, Taira N, Sawaki M. Cost-Effectiveness of Trastuzumab With or
Without Chemotherapy as Adjuvant Therapy in HER2-Positive Elderly Breast Cancer Patients: A
Randomized, Open-Label Clinical Trial, the RESPECT Trial. Clin Drug Investig. 2022
Mar;42(3):253-262. doi: 10.1007/s40261-022-01124-y. Epub 2022 Mar 1. PMID: 35233755;
PMCID: PMC8930935.
140. Tomita N, Morino E, Terada-Hirashima J, Uemura Y, Shimizu Y, Saito S, Suzuki T, Okumura N,
Iwasaki H, Ebihara H, Shimojima M, Sugiura W, Ohmagari N, Ujiie M. Evaluating the
Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A
Single-Arm Study. Life (Basel). 2023 Mar 14;13(3):787.
139. Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T,
Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y,
Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y,
Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y,
Tamamura H, Mitsuya H. Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4fluorobenzothiazole moiety highly active against SARS-CoV-2. Nat Commun. 2023 Feb
25;14(1):1076. doi: 10.1038/s41467-023-36729-0. PMID: 36841831; PMCID: PMC9958325.
138. Amano M, Ichikawa Y, Uemura Y, Matsumoto S, Maeda K, Matsushita S, Shimada S, Mitsuya H.
Comparison of neutralization activity against Omicron BA.2/BA.5 in sera from HCWs receiving
heterologous/homologous COVID-19 vaccines. J Infect. 2023 Feb 2:S0163-4453(23)00066-X.
137. Ohta H, Uemura Y*, Sone T, Tanaka S, Soen S, Mori S, Hagino H, Fukunaga M, Nakamura T,
Orimo H, Shiraki M; Adequate Treatment of Osteoporosis (A-TOP) research group. Effect of Bone
Resorption Inhibitors on Serum Cholesterol Level and Fracture Risk in Osteoporosis: Randomized
Comparative Study Between Minodronic Acid and Raloxifene. Calcif Tissue Int. 2023

Apr;112(4):430-439. doi: 10.1007/s00223-023-01060-9.
136. Fujii H, Hamano T, Tsuchiya K, Kuragano T, Joki N, Tsuruya K, Honda H, Uemura Y, Nitta K;
PARAMOUNT Study Investigators. Not baseline but time-dependent erythropoiesis-stimulating
agent responsiveness predicts cardiovascular disease in hemodialysis patients receiving epoetin beta
pegol: A multicenter prospective PARAMOUNT-HD Study. Int J Cardiol. 2023 Mar 15;375:110-118.
135. Taguchi, S., Kawai, T., Nakagawa, T., Miyakawa, J., Kishitani, K., Sugimoto, K., Nakamura, Y.,
Kamei, J., Obinata, D., Yamaguchi, K., Kaneko, T., Yoshida, K., Yamamoto, S., Kakutani, S.,
Kanazawa, K., Sugihara, Y., Tokunaga, M., Matsumoto, A., Uemura, Y., Akiyama, Y., … Kume, H.
(2022). Improved survival in real-world patients with advanced urothelial carcinoma: A multicenter
propensity score-matched cohort study comparing a period before the introduction of
pembrolizumab (2003-2011) and a more recent period (2016-2020). International journal ofurology : official journal of the Japanese Urological Association, 29(12), 1462–1469.
https://doi.org/10.1111/iju.15014
134. Takeda Y, Kusaba Y, Tsukita Y, et al. The efficacy profiles of concurrent chemoradiotherapy withintensity-modulated radiotherapy followed by durvalumab in patients with unresectable stage III
non-small cell lung cancer: A multicenter retrospective cohort study. Clin Transl Radiat Oncol.
2022;37:57-63. Published 2022 Aug 23. doi:10.1016/j.ctro.2022.08.010
133. Terada-Hirashima, J., Izumi, S., Katagiri, D., Uemura, Y., Mikami, A., Sugiura, W., Abe, S., Azuma,
A., & Sugiyama, H. (2022). Efficacy and Safety of Direct Hemoperfusion Using Polymyxin BImmobilized Polystyrene Column for Patients With COVID-19: Protocol for an Exploratory Study.
JMIR research protocols, 11(11), e37426. https://doi.org/10.2196/37426
132. Narui, K., Ishikawa, T., Taira, N., Uemura, Y., & Mukai, H. (2022). Prospective Cohort Study ofPalbociclib Treatment in Postmenopausal Patients With Unresectable and Metastatic Hormone
Receptor-Positive Breast Cancer: Study Protocol for a CSPOR-BC Palbociclib Cohort Trial. World
journal of oncology, 13(4), 190–194. https://doi.org/10.14740/wjon1507
131. Miyahara, K., Narui, K., Uemura, Y., Yamada, A., Araki, K., Fujisawa, F., Nakayama, T., Ishikawa,T., Taira, N., Kikawa, Y., Aihara, T., & Mukai, H. (2022). Prospective Cohort Study of Combination
Therapy With Abemaciclib and Hormonal Therapy for Chemotherapy-Treated Patients With
Hormone Receptor-Positive Metastatic Breast Cancer. World journal of oncology, 13(4), 216–221.
https://doi.org/10.14740/wjon1511
130. Sugawara, K., Yamashita, H., Urabe, M., Uemura, Y., Okumura, Y., Yagi, K., Aikou, S., & Seto, Y.
(2022). Combining nutritional status with TNM stage: a physiological update on gastric cancer
staging for improving prognostic accuracy in elderly patients. International journal of clinicaloncology, 27(12), 1849–1858. https://doi.org/10.1007/s10147-022-02250-5
129. Terada-Hirashima, J., Suzuki, M., Tsujimoto, Y., Hamamoto, Y., Uemura, Y., Tsushima, K., Inoue,
H., Komatsu, S., Saito, Z., Tsuzuki, R., Okamoto, M., To, Y., Moriya, K., Yoshizawa, S., Tanaka, M.,Muto, T., Mikami, A., Takasaki, J., Izumi, S., Ohmagari, N., … Sugiyama, H. (2022). Impact of
inhaled ciclesonide on asymptomatic or mild COVID-19: A randomized trial. Drug discoveries &therapeutics, 16(5), 225–232. https://doi.org/10.5582/ddt.2022.01068
128. Sawaki, M., Taira, N., Uemura, Y., Saito, T., Baba, S., Kobayashi, K., Kawashima, H., Tsuneizumi,
M., Sagawa, N., Bando, H., Takahashi, M., Yamaguchi, M., Takashima, T., Nakayama, T.,
Kashiwaba, M., Mizuno, T., Yamamoto, Y., Iwata, H., Toyama, T., Tsugawa, K., … RESPECT study
group (2022). Adjuvant trastuzumab without chemotherapy for treating early HER2-positive breast
cancer in older patients: A propensity score-adjusted analysis of a prospective cohort study. Breast(Edinburgh, Scotland), 66, 245–254. https://doi.org/10.1016/j.breast.2022.10.017
127. Sugawara K, Fukuda T, Kishimoto Y, Oka D, Yoshii T, Hara H, Uemura Y, Kawashima Y, Kanda
H, Motoi N. Influences of intratumoral heterogeneity on assessment of tumor microenvironment inesophageal

squamouscellcarcinoma.

CancerSci.

2023

Mar;114(3):1180-1191.

doi:

10.1111/cas.15665. Epub 2022 Dec 11. PMID: 36424361; PMCID: PMC9986096.
126. Fujii, H., Hamano, T., Tsuchiya, K., Kuragano, T., Joki, N., Tsuruya, K., Honda, H., Uemura, Y.,
Nitta, K., & PARAMOUNT Study Investigators (2022). Not baseline but time-dependent
erythropoiesis-stimulating agent responsiveness predicts cardiovascular disease in hemodialysis
patients receiving epoetin beta pegol: A multicenter prospective PARAMOUNT-HD Study.
International journal of cardiology, S0167-5273(22)01976-3. Advance online publication.
https://doi.org/10.1016/j.ijcard.2022.12.051
125. Tsuzuki S, Hayakawa K, Uemura Y, Shinozaki T, Matsunaga N, Terada M, Suzuki S, Asai Y,
Kitajima K, Saito S, Yamada G, Shibata T, Kondo M, Izumi K, Hojo M, Mizoue T, Yokota K,
Nakamura-Uchiyama F, Saito F, Sugiura W, Ohmagari N. Effectiveness of remdesivir in hospitalized
nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19
Registry Japan. Int J Infect Dis. 2022 May;118:119-125. doi: 10.1016/j.ijid.2022.02.039.
124. Tsuzuki S, Hayakawa K, Doi Y, Shinozaki T, Uemura Y, Matsunaga N, Terada M, Suzuki S, AsaiY, Yamada G, Saito S, Shibata T, Kondo M, Izumi K, Hojo M, Mizoue T, Yokota K, NakamuraUchiyama F, Saito F, Sugiura W, Ohmagari N. Effectiveness of Favipiravir on Nonsevere, EarlyStage COVID-19 in Japan: A Large Observational Study Using the COVID-19 Registry Japan. Infect
Dis Ther. 2022 Jun;11(3):1075-1087. doi: 10.1007/s40121-022-00617-9.
123. Tomita N, Saito S, Terada-Hirashima J, Mikami A, Uemura Y, Kutsuna S, Nomoto H, Fujisawa K,
Nagashima M, Terada M, Ashida S, Morioka S, Satake M, Hangaishi A, Togano T, Shiratori K,
Takamatsu Y, Maeda K, Ohmagari N, Sugiura W, Mitsuya H. A Multi-Center, Open-Label,Randomized Controlled Trial to Evaluate the Efficacy of Convalescent Plasma Therapy forCoronavirus Disease 2019: A Trial Protocol (COVIPLA-RCT). Life (Basel). 2022 Jun 8;12(6):856.
doi: 10.3390/life12060856.
122. Kato T, Momose M, Uemura Y, Naya M, Matsumoto N, Hida S, Yamauchi T, Nakajima T, Suzuki

E, Inoko M, Tamaki N. Association of the extent of myocardial ischemia with outcomes in patientswith suspected coronary artery disease in Japan. J Cardiol. 2022 Nov;80(5):475-481. doi:
10.1016/j.jjcc.2022.06.012. Epub 2022 Jul 12. PMID: 35835641.
121. Terada-Hirashima J, Sugiura W, Shimizu Y, Tanaka Y, Uemura Y, Ishikane M, Kazuyama Y, Ikeda
M, Wakabayashi K, Ohmagari N, Kimura M. Investigation of the use of PCR testing prior to shipboarding to prevent the spread of SARS-CoV-2 from urban areas to less-populated remote islands.
Glob Health Med. 2022 Jun 30;4(3):174-179. doi: 10.35772/ghm.2022.01008. PMID: 35855067;
PMCID: PMC9243411.
120. Kawahara T, Iwamoto T, Takashima I, Hanazawa R, Uemura K, Uemura Y, Mukai H, Kikawa Y,
Taira N. Association of change in health-related quality of life and treatment discontinuation inmetastatic breast cancer: a post hoc, exploratory analysis of two randomized clinical trials. Support
Care Cancer. 2022 Oct;30(10):8367-8375. doi: 10.1007/s00520-022-07283-0. Epub 2022 Jul 20.
PMID: 35857127; PMCID: PMC9512887.
119. Terayama Y, Tomita N, Terada-Hirashima J, Uemura Y, Shimizu Y, Takeuchi JS, Takamatsu Y,
Maeda K, Mikami A, Ujiie M, Sugiura W. Protocol of an Exploratory Single-Arm Study to Evaluate
the Safety and Immunogenicity of KD-414 as a Booster Vaccine for SARS-CoV-2 in Healthy Adults(KAPIVARA). Life (Basel). 2022 Jun 27;12(7):966. doi: 10.3390/life12070966.
118. Amano M, Otsu S, Maeda K, Uemura Y, Shimizu Y, Omata K, Matsuoka M, Shimada S, Mitsuya
H. Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals
against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variants. Sci Rep. 2022 Aug
8;12(1):13524. doi: 10.1038/s41598-022-17071-9.
117. Taguchi S, Kawai T, Nakagawa T, Miyakawa J, Kishitani K, Sugimoto K, Nakamura Y, Kamei J,
Obinata D, Yamaguchi K, Kaneko T, Yoshida K, Yamamoto S, Kakutani S, Kanazawa K, Sugihara
Y, Tokunaga M, Matsumoto A, Uemura Y, Akiyama Y, Yamada Y, Sato Y, Yamada D, Enomoto Y,
Nishimatsu H, Ishikawa A, Tanaka Y, Nagase Y, Fujimura T, Fukuhara H, Takahashi S, Kume H.
Improved survival in real-world patients with advanced urothelial carcinoma: A multicenter
propensity score-matched cohort study comparing a period before the introduction of
pembrolizumab (2003-2011) and a more recent period (2016-2020). Int J Urol. 2022
Dec;29(12):1462-1469.
116. Takeda Y, Kusaba Y, Tsukita Y, Uemura Y, Miyauchi E, Yamamoto T, Mayahara H, Hata A,
Nakayama H, Tanaka S, Uchida J, Usui K, Toyoda T, Tamiya M, Morimoto M, Oya Y, Kodaira T,
Jingu K, Sugiura H. The efficacy profiles of concurrent chemoradiotherapy with intensity-modulated
radiotherapy followed by durvalumab in patients with unresectable stage III non-small cell lungcancer: A multicenter retrospective cohort study. Clin Transl Radiat Oncol. 2022 Aug 23;37:57-63.
doi: 10.1016/j.ctro.2022.08.010.
115. Miyahara K, Narui K, Uemura Y, Yamada A, Araki K, Fujisawa F, Nakayama T, Ishikawa T, TairaN, Kikawa Y, Aihara T, Mukai H. Prospective Cohort Study of Combination Therapy With
Abemaciclib and Hormonal Therapy for Chemotherapy-Treated Patients With Hormone ReceptorPositive

Metastatic

BreastCancer.

World

J

Oncol.

2022

Aug;13(4):216-221.

doi:

10.14740/wjon1511.
114. Terada-Hirashima J, Izumi S, Katagiri D, Uemura Y, Mikami A, Sugiura W, Abe S, Azuma A,
Sugiyama H. Efficacy and Safety of Direct Hemoperfusion Using Polymyxin B-Immobilized
Polystyrene Column for Patients With COVID-19: Protocol for an Exploratory Study. JMIR Res
Protoc. 2022 Nov 16;11(11):e37426. doi: 10.2196/37426.
113. Narui K, Ishikawa T, Taira N, Uemura Y, Mukai H. Prospective Cohort Study of Palbociclib
Treatment in Postmenopausal Patients With Unresectable and Metastatic Hormone ReceptorPositive Breast Cancer: Study Protocol for a CSPOR-BC Palbociclib Cohort Trial. World J Oncol.
2022 Aug;13(4):190-194. doi: 10.14740/wjon1507.
112. Takamatsu Y, Omata K, Shimizu Y, Kinoshita-Iwamoto N, Terada M, Suzuki T, Morioka S, Uemura
Y, Ohmagari N, Maeda K, Mitsuya H. SARS-CoV-2-Neutralizing Humoral IgA Response Occurs
Earlier but Is Modest and Diminishes Faster than IgG Response. Microbiol Spectr. 2022.
21;10(6):e0271622..
111. Sugawara K, Yamashita H, Urabe M, Uemura Y, Okumura Y, Yagi K, Aikou S, Seto Y. Combining
nutritional status with TNM stage: a physiological update on gastric cancer staging for improving
prognostic accuracy in elderly patients. Int J Clin Oncol. 2022 Dec;27(12):1849-1858.
110. Terada-Hirashima J, Suzuki M, Tsujimoto Y, Hamamoto Y, Uemura Y, Tsushima K, Inoue H,
Komatsu S, Saito Z, Tsuzuki R, Okamoto M, To Y, Moriya K, Yoshizawa S, Tanaka M, Muto T,
Mikami A, Takasaki J, Izumi S, Ohmagari N, Hojo M, Sugiura W, Sugiyama H. Impact of inhaled
ciclesonide on asymptomatic or mild COVID-19: A randomized trial. Drug Discov Ther. 2022 Nov
20;16(5):225-232
109. Sawaki M, Taira N, Uemura Y, Saito T, Baba S, Kobayashi K, Kawashima H, Tsuneizumi M,
Sagawa N, Bando H, Takahashi M, Yamaguchi M, Takashima T, Nakayama T, Kashiwaba M,
Mizuno T, Yamamoto Y, Iwata H, Toyama T, Tsugawa K, Kawahara T, Mukai H; RESPECT study
group. Adjuvant trastuzumab without chemotherapy for treating early HER2-positive breast cancer
in older patients: A propensity score-adjusted analysis of a prospective cohort study. reast. 2022
Dec;66:245-254.
108. Kawahara T, Taira N, Shiroiwa T, Hagiwara Y, Fukuda T, Uemura Y, Mukai H. Minimal importantdifferences of EORTC QLQ-C30 for metastatic breast cancer patients: Results from a randomized
clinical trial. Qual Life Res. 2022 Jun;31(6):1829-1836. doi: 10.1007/s11136-021-03074-y. Epub
2022 Jan 4. PMID: 34982354; PMCID: PMC9098551.
107. Ebata S, Oba K, Kashiwabara K, Ueda K, Uemura Y, Watadani T, Fukasawa T, Miura S, YoshizakiOgawa A, Yoshihide A, Yoshizaki A, Sato S. Predictors of Rituximab Effect on Modified Rodnan

Skin Score in Systemic Sclerosis: a machine learning analysis of the DESIRES trial. Rheumatology(Oxford). 2022 Nov 2;61(11):4364-4373. doi: 10.1093/rheumatology/keac023. PMID: 35136981.
106. Yamasue H, Kojima M, Kuwabara H, Kuroda M, Matsumoto K, Kanai C, Inada N, Owada K, Ochi
K, Ono N, Benner S, Wakuda T, Kameno Y, Inoue J, Harada T, Tsuchiya K, Umemura K, Yamauchi
A, Ogawa N, Kushima I, Ozaki N, Suyama S, Saito T, Uemura Y, Hamada J, Kano Y, Honda N,
Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M,
Nakamura I, Isomura S, Hirano Y, Onitsuka T, Kosaka H, Okada T. Effect of a novel nasal oxytocin
spray with enhanced bioavailability on autism: a randomized trial. Brain. 2022 Apr 18;145(2):490499. doi: 10.1093/brain/awab291. PMID: 35067719.
105. Hiroi Y, Ohtsu H, Uemura Y, Hayakawa K, Asai Y, Kutsuna S, Terada M, Sugiura W, Ohmagari N.
Cardiovascular Complications of Hospitalized Patients With Coronavirus Disease 2019 in a JapaneseRegistry in 2020. Circ J. 2022 Feb 25;86(3):464-471. doi: 10.1253/circj.CJ-21-0687. Epub ahead ofprint. PMID: 35095056.
104. Maeda K, Amano M, Uemura Y, Tsuchiya K, Matsushima T, Noda K, Shimizu Y, Fujiwara A,
Takamatsu Y, Ichikawa Y, Nishimura H, Kinoshita M, Matsumoto S, Gatanaga H, Yoshimura K, Oka
SI, Mikami A, Sugiura W, Sato T, Yoshida T, Shimada S, Mitsuya H. Correlates ofneutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics
in BNT162b2-vaccinated individuals. Sci Rep. 2021 Nov 24;11(1):22848. doi: 10.1038/s41598-02101930-y. PMID: 34819514; PMCID: PMC8613264.
103. Ebata S, Yoshizaki A, Oba K, Kashiwabara K, Ueda K, Uemura Y, Watadani T, Fukasawa T, Miura
S, Yoshizaki-Ogawa A, Asano Y, Okiyama N, Kodera M, Hasegawa M, Sato S. Safety and efficacyof rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised,
placebo-controlled

trial.

LancetRheumatol.

2021

July;

3(7):

e489-e497.

DOI:

https://doi.org/10.1016/S2665-9913(21)00107-7
102. Taguchi A, Uemura Y, Tanaka S, Ohta H, Mori S, Hagino H, Shiraki M, Nakamura T, Soen S;
Adequate Treatment of Osteoporosis (A-TOP) research group. Influence of symptomatic periodontal
disease on changes in skeletal bone density during medication therapy for osteoporosis in
postmenopausal women: the Japanese Osteoporosis Intervention Trial (JOINT)-04 and JOINT-05.
Arch Osteoporos. 2021 Dec 27;17(1):7. doi: 10.1007/s11657-021-01054-w. PMID: 34958402.
101. Mukai H, Uemura Y, Akabane H, Watanabe T, Park Y, Takahashi M, Sagara Y, Nishimura R,
Takashima T, Fujisawa T, Hozumi Y, Kawahara T. Anthracycline-containing regimens or taxane
versus S-1 as first-line chemotherapy for metastatic breast cancer. Br J Cancer. 2021
Oct;125(9):1217-1225. doi: 10.1038/s41416-021-01531-6. Epub 2021 Sep 3. PMID: 34480096;
PMCID: PMC8548517.
100 Sakamaki K, Uemura Y, Shimizu Y. Definitions and elements of endpoints in phase III randomized
trials for the treatment of COVID-19: a cross-sectional analysis of trials registered inClinicalTrials.gov. Trials. 2021;22(1):788. Published 2021 Nov 8. doi:10.1186/s13063-021-0576399 Hara H, Uemura Y, Hayakawa K, Togano T, Asai Y, Matsunaga N, Terada M, Ohtsu H, Kitajima K,
Shimizu Y, Sato L, Ishikane M, Kinoshita-Iwamoto N, Shibata T, Kondo M, Izumi K, Sugiura W,
Ohmagari N. Evaluation of the efficacy of anticoagulation therapy in reducing mortality in anationwide cohort of hospitalized patients with coronavirus disease in Japan. Int J Infect Dis. 2021
Sep 10;112:111-116. doi: 10.1016/j.ijid.2021.09.014. Epub ahead of print. PMID: 34517044;
PMCID: PMC8432973.
98 Ishiguro T, Kobayashi Y, Shimizu Y, Uemura Y, Isono T, Takano K, Nishida T, Kobayashi Y, Hosoda
C, Takaku Y, Shimizu Y, Takayanagi N. Frequency and Significance of Coinfection in Patients with
COVID-19 at Hospital Admission. Intern Med. 2021 Sep 18. doi: 10.2169/internalmedicine.802121. Epub ahead of print. PMID: 34544950.
97 Hagiwara Y, Sawaki M, Uemura Y, Kawahara T, Shimozuma K, Ohashi Y, Takahashi M, Saito T, Baba
S, Kobayashi K, Mukai H, Taira N. Impact of chemotherapy on cognitive functioning in older
patients with HER2-positive breast cancer: a sub-study in the RESPECT trial. Breast Cancer Res
Treat. 2021 Aug;188(3):675-683. doi: 10.1007/s10549-021-06253-0. Epub 2021 Jun 2. PMID:
34080094.
96 Hayama H, Ide S, Moroi M, Kitami Y, Bekki N, Kubota S, Uemura Y, Hara H, Kutsuna S, Ohmagari
N, Hiroi Y. Elevated high-sensitivity troponin is associated with subclinical cardiac dysfunction inpatients recovered from coronavirus disease 2019. Glob Health Med. 2021 Apr 30;3(2):95-101. doi:
10.35772/ghm.2021.01025. PMID: 33937572; PMCID: PMC8071685.
95 Ikeda Y, Adachi K, Tomio K, Eguchi-Kojima S, Tsuruga T, Uchino-Mori M, Taguchi A, Komatsu A,
Nagamatsu T, Oda K, Kawana-Tachikawa A, Uemura Y, Igimi S, Osuga Y, Fujii T, Kawana K. A
Placebo-Controlled, Double-Blind Randomized (Phase IIB) Trial of Oral Administration with
HPV16 E7-Expressing Lactobacillus, GLBL101c, for the Treatment of Cervical Intraepithelial
Neoplasia Grade 2 (CIN2). Vaccines (Basel). 2021 Apr 1;9(4):329. doi: 10.3390/vaccines9040329.
PMID: 33915901; PMCID: PMC8066592.
94 Mukai H, Uemura Y, Akabane H, Watanabe T, Park Y, Takahashi M, Sagara Y, Nishimura R,
Takashima T, Fujisawa T, Hozumi Y, Kawahara T. Anthracycline-containing regimens or taxane
versus S-1 as first-line chemotherapy for metastatic breast cancer. Br J Cancer. 2021 Sep 3. doi:
10.1038/s41416-021-01531-6. Epub ahead of print. PMID: 34480096.
93 Togano T, Uemura Y, Asai Y, Hayakawa K, Matsunaga N, Terada M, Ohtsu H, Suzuki S, Toyoda A,
Hara H, Sato R, Ishikane M, Kinoshita-Iwamoto N, Hangaishi A, Ohmagari N. The influence of preadmission antiplatelet and anticoagulation therapy on the illness severity in hospitalized patientswith

COVID-19

inJapan.

J

InfectChemother.

2021

Oct;27(10):1498-1503.

doi:

10.1016/j.jiac.2021.07.016. Epub 2021 Jul 24. PMID: 34340930; PMCID: PMC8302845.
92 Taira N, Sawaki M, Uemura Y, Saito T, Baba S, Kobayashi K, Kawashima H, Tsuneizumi M, Sagawa

N, Bando H, Takahashi M, Yamaguchi M, Takashima T, Nakayama T, Kashiwaba M, Mizuno T,
Yamamoto Y, Iwata H, Ohashi Y, Mukai H, Kawahara T; RESPECT Study Group. Health-Related
Quality of Life With Trastuzumab Monotherapy Versus Trastuzumab Plus Standard Chemotherapy
as Adjuvant Therapy in Older Patients With HER2-Positive Breast Cancer. J Clin Oncol. 2021 Aug
1;39(22):2452-2462. doi: 10.1200/JCO.20.02751. Epub 2021 Apr 9. PMID: 33835842.
91 Taguchi S, Nakagawa T, Uemura Y, Akamatsu N, Gonoi W, Naito A, Kawai T, Kume H, Fukuhara H.
Comparison of major definitions of sarcopenia based on the skeletal muscle index in patients withurothelial carcinoma. Future Oncol. 2021 Jan;17(2):197-203. doi: 10.2217/fon-2020-0570.
89. Tsuruya K, Hayashi T, Yamamoto H, Hase H, Nishi S, Yamagata K, Nangaku M, Wada T, Uemura Y,
Ohashi Y, Hirakata H; RADIANCE-CKD Study Investigators. Renal prognoses by different target
hemoglobin levels achieved by epoetin beta pegol dosing to chronic kidney disease patients withhyporesponsive anemia to erythropoiesis-stimulating agent: a multicenter open-label randomized
controlled study. Clin Exp Nephrol. 2021 Jan 7. doi: 10.1007/s10157-020-02005-4. Online ahead ofprint.
88. Hagino H, Uemura Y, Mori S, Sone T, Ohta H, Nakamura T. Risk factors for incident vertebral
fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study. J Bone Miner
Metab. 2021 Jul;39(4):668-677. doi: 10.1007/s00774-021-01208-3. Epub 2021 Mar 18. PMID:
33738617.
87. Takashima T*, Hara F*, Iwamoto T, Uemura Y, Ohsumi S, Yotsumoto D, Hozumi Y, Watanabe T,
Saito T, Watanabe KI, Tsurutani J, Toyama T, Akabane H, Nishimura R, Taira N, Ohashi Y, Mukai
H. A Correlation Analysis Between Metabolism-related Genes and Treatment Response to S-1 asFirst-line Chemotherapy for Metastatic Breast Cancer: The SELECT BC-EURECA Study. Clin
Breast Cancer. 2021 Feb 1:S1526-8209(21)00040-9. doi: 10.1016/j.clbc.2021.01.018. Epub aheadof print. PMID: 33685834.
86. Shiiya H, Nakajima N, Date H, Chen-Yoshikawa T, Tanizawa K, Handa T, Oto T, Otani S, Shiotani T,
Okada Y, Matsuda Y, Shiraishi T, Moroga T, Minami M, Funaki S, Chida M, Yoshino I, Hatachi G,
Uemura Y, Sato M. Outcomes of lung transplantation for idiopathic pleuroparenchymal
ibroelastosis. Surgery Today. 2021 Aug;51(8):1276-1284. doi: 10.1007/s00595-021-02232-6. Epub
2021 Feb 12. PMID: 33576927.
85. Taguchi S, Nakagawa T, Uemura Y, Akamatsu N, Gonoi W, Naito A, Kawai T, Kume H, Fukuhara
H. Comparison of major definitions of sarcopenia based on the skeletal muscle index in patients withurothelial carcinoma. Future Oncol. 2020 Dec 11. doi: 10.2217/fon-2020-0570. Epub ahead of print.
80 Itoi E, Uemura Y, Ohta H, Nakamura T, Fukunaga M, Orimo H, Shiraki M. Impact of bone mineraldensity in reducing fracture risk in patients receiving alendronate plus alfacalcidol therapy. J Orthop
Sci, 2020, Dec 22;S0949-2658(20)30332-8. doi: 10.1016/j.jos.2020.10.017. Online ahead of print.
84. Uemura Y, Sone T, Tanaka S, Miyazaki T, Tsukiyama M, Taguchi A, Soen S, Mori S, Hagino H,

Sugimoto T, Fukunaga M, Ohta H, Nakamura T, Orimo H, Shiraki M; Adequate Treatment of
Osteoporosis (A-TOP) Research Group. Randomized head-to-head comparison of minodronic acidand raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis
Intervention Trial (JOINT)-04. Curr Med Res Opin. 2020 Nov;36(11):1847-1859.
83 Terada-Hirashima J, Suzuki M, Uemura Y, Hojo M, Mikami A, Sugiura W, Ohmagari N, Sugiyama
H. The RACCO Trial to Assess the Efficacy and Safety of Inhaled Ciclesonide for Asymptomaticand Mild Patients with Covid-19: A Study Protocol for a Multi-center, Open- labeled, Randomized
Controlled Trial. JMIR Res Protoc. 2020 Dec 31;9(12):e23830.
82 Matsuda W, Uemura T, Yamamoto M, Uemura Y, Kimura A. Impact of frailty on protocol-based
weaning from mechanical ventilation in patients with sepsis: a retrospective cohort study. Acute Med
Surg, 2020 Nov 30;7(1):e608.
79 Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Asai Y, Tsuzuki S, Suzuki S, Toyoda A, Suzuki K,
Endo M, Fujii N, Suzuki M, Saito S, Uemura Y, Shibata T, Kondo M, Izumi K, Terada-Hirashima
J, Mikami A, Sugiura W, Ohmagari N. Clinical epidemiology of hospitalized patients with COVID19 in Japan: Report of the COVID-19 REGISTRY JAPAN. Clin Infect Dis, 2020 Sep 28:ciaa1470.
doi: 10.1093/cid/ciaa1470.
78 Takao-Okuma H, Terao R, Nagahara M, Azuma K, Inoue T, Uemura Y, Obata R. Distribution ofrecurrence time intervals after anti-vascular endothelial growth factor therapy for myopic choroidal
neovascularization. Can J Ophthalmol. 2020 Sep 10:S0008-4182(20)30712-2.
77 Kato T, Uemura Y, Naya M, Matsumoto N, Momose M; Hida S; Yamauchi T, Nakajima T, Suzuki S,
Shiga T, Tamaki N. Association of Coronary Revascularization after Physician-Referred NonInvasive Diagnostic Imaging Tests with Outcomes in Patients with Suspected Coronary Artery
Disease: A Post Hoc Subgroup Analysis. BMJ open, 2020 Sep 6;10(9):e035111.
76 Sawaki M, Taira N, Uemura Y, Saito T, Baba S, Kobayashi K, Kawashima H, Tsuneizumi M, Sagawa
N, Bando H, Takahashi M, Yamaguchi M, Takashima T, Nakayama T, Kashiwaba M, Mizuno T,
Yamamoto Y, Iwata H, Kawahara T, Ohashi Y, Mukai H; RESPECT study group. Randomized
Controlled Trial of Trastuzumab With or Without Chemotherapy for HER2-Positive Early Breast
Cancer in Older Patients. J Clin Oncol, 2020 Nov 10;38(32):3743-3752.
75 Iwamoto T, Hara F, Uemura Y, Mukai H, Watanabe T, Ohashi Y. NSAS BC02 substudy ofchemotherapy induced amenorrhea (CIA) in premenopausal patients who received either taxane
alone or doxorubicin(A) cyclophosphamide(C) followed by taxane as postoperative chemotherapy.
Breast Cancer Res Treat, 2020 Jul;182(2):325-332. doi: 10.1007/s10549-020-05692-5.74
74 Sugawara K, Yagi K, Uemura Y, Okumura Y, Nishida M, Aikou S, Yamashita H, Seto Y. Associationsof systemic inflammation and sarcopenia with survival of esophageal carcinoma patients. The
Annals of Thoracic Surgery, 2020 Aug;110(2):374-382. doi: 10.1016/j.athoracsur.2020.03.013.
73 Nakayama A, Nagayama M, Morita H, Tajima M, Mahara K, Uemura Y, Tomoike H, Komuro I, IsobeM. A Large-scale Cohort Study of Long-term Cardiac Rehabilitation: A prospective cross-sectional
study. Int J Cardiol, 2020 Jun 15;309:1-7. doi: 10.1016/j.ijcard.2020.03.022.
72 Sugawara K, Aikou S, Yajima S, Uemura Y, Okumura Y, Nishida M, Yagi K, Yamashita H, Seto Y.
Pre- and post-operative low prognostic nutritional index influences survival in elderly gastriccarcinoma patients. J Geriatr Oncol, 2020 Jul;11(6):989-996. doi: 10.1016/j.jgo.2020.02.007.
71 Sugawara K, Yamashita H, Yajima S, Uemura Y, Okumura Y, Nishida M, Yagi K, Aikou S, Seto Y.
Preoperative restrictive pulmonary dysfunction influences survival after gastrectomy for elderly
patients with gastric carcinoma. Surg Today, 2020 Sep;50(9):1065-1073. doi: 10.1007/s00595-02001983-y.
70 Mukai H, Yamaguchi T, Takahashi M, Hozumi Y, Fujisawa T, Ohsumi S, Akabane H, Nishimura R,
Takashima T, Park Y, Sagara Y, Toyama T, Imoto S, Mizuno T, Yamashita S, Fujii S, Uemura Y.
Ki-67 Response-Guided Preoperative Chemotherapy for HER2-Positive Breast Cancer: Results of a
Randomized Phase II Study. Br J Cancer. 2020 Jun;122(12):1747-1753.
69 Otsuka-Ono H, Hori N, Ohta H, Uemura Y, Kamibeppu K. Childhood Immunization Education
Program for Parents Delivered during Late Pregnancy and One-month Postpartum: A Randomized
Controlled Trial. BMC Health Services Research, 2019 Nov 5;19(1):798. doi: 10.1186/s12913-0194622-z..
68 Ueda K, Uemura Y, Sato M. Protocol for the VAL-MAP 2.0 trial: a multicenter, single-arm, phase Ⅲ
trial to evaluate the effectiveness of virtual-assisted lung mapping by bronchoscopic dye injection andmicrocoil implementation in patients with small pulmonary nodules in Japan. BMJ open, 2019 Sep;
4;9(9):e028018. doi: 10.1136/bmjopen-2018-028018.
67 Tian D, Wang Z, Shiiya H, Sun, Uemura Y, Sato M, Nakajima J. Outcomes of marginal donors forlung transplantation after ex vivo lung perfusion: A systematic review and meta-analysis. The
Journal of Thoracic and Cardiovascular Surgery, 2019 Aug 25. pii: S0022-5223(19)31641-1. doi:
10.1016/j.jtcvs.2019.07.087.
66 Uemura Y, Taguri M, Kawahara T, Chiba Y. Simple methods for the estimation and sensitivity analysis
of principal strata effects using marginal structural models: application to a bone fracture prevention
trial. Biometrical Journal, 2019 Nov;61(6):1448-1461. doi: 10.1002/bimj.201800038.
65 Ikeda Y, Uemura Y, Asai-Sato M, Nakao T, Nakajima T, Iwata T , Akiyama A, Satoh T, Yahata H,
Kato K, Maeda D, Aoki D, Kawana K. Safety and efficacy of mucosal immunotherapy using humanpapillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of highgrade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-controlled
clinical trial (MILACLE study). Japanese Journal of Clinical Oncology, 2019 Sep 1;49(9):877880. doi: 10.1093/jjco/hyz095.
64 Ko T, Fujita K, Nomura S, Uemura Y, Yamada S, Tobita T, Katoh M, Satoh M, Ito M, Domoto Y,
Hosoya Y, Amiya E, Hatano M, Morita H, Fukayama M, Aburatani H, Komuro I. Quantification of

DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis. JACC: Basic
to Translational Science, 2019 Sep 25;4(6):670-680. doi: 10.1016/j.jacbts.2019.05.010. eCollection2019 Oct.
63 Suzuki A, Obi Y, Hayashi T, Kotani N, Uemura Y, Imai E, Makino H, Hishida A. Visit-to-visit
variability in estimated glomerular filtration rate predicts hospitalization and death due tocardiovascular events. Clin Exp Nephrol. 2019 May;23(5):661-668. doi: 10.1007/s10157-01901695-9.
62 Ohno S, Mukai H, Narui K, Hozumi Y, Miyoshi Y, Yoshino H, Doihara H, Suto A, Tamura M,
Morimoto T, Zaha H, Chishima T, Nishimura R, Ishikawa T, Uemura Y, Ohashi Y. Participants in arandomized controlled trial had longer overall survival than non-participants: a prospective cohort
study. Breast Cancer Res Treat. 2019 Aug;176(3):631-635. doi: 10.1007/s10549-019-05276-y.
61 Kato T, Uemura Y, Naya M, Momose M, Matsumoto N, Suzuki E, Hida S, Nakajima T, Yamauchi T,
Tamaki N. Impact of renal dysfunction on the choice of diagnostic imaging, treatment strategy, andoutcomes in patients with stable angina. Sci Rep. 2019 May 27;9(1):7882. doi: 10.1038/s41598019-44371-4.
60 Owada K, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D,
Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Yassin W, Kushima I, Benner
S, Ogawa N, Kawano K, Eriguchi Y, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H,
Ozaki N, Kosaka H, Yamasue H. Quantitative facial expression analysis revealed the efficacy andtime-course of oxytocin in autism. Brain, 2019 May 16. pii: awz126. doi: 10.1093/brain/awz126.
[Epub ahead of print]
59 Taguchi A, Uemura Y, Imai T, Tanaka S, Ohta H, NakamuraT, Orimo H, Sugimoto T, Soen S, Shiraki
M, Adequate Treatment of Osteoporosis (A-TOP) research group. Incidence of osteonecrosis of thejaws in Japanese osteoporosis patients who take minodronic acid: Japanese Osteoporosis
Intervention Trial (JOINT)-04. Journal of Bone and Mineral Metabolism, J Bone Miner Metab.
2019 Feb 4. doi: 10.1007/s00774-019-00990-5. [Epub ahead of print]
58 Sugawara K, Mori K, Yagi K, Aikou S, Uemura Y, Yamashita H, Seto Y. Association of preoperative
inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy.
Disease of the Esophagus., 2019 Apr 1;32(4). pii: doy066. doi: 10.1093/dote/doy066.
57 Sugawara M, Goto Y, Yamazaki T, Teramoto T, Oikawa S, Shimada K, Uchiyama S, Ando K, Ishizuka
N, Murata M, Yokoyama K, Uemura Y, Ikeda Y. Low-Dose Aspirin for Primary Prevention of

Cardiovascular Events in Elderly Japanese Patients with Atherosclerotic Risk Factors:
Subanalysis of a Randomized Clinical Trial (JPPP-70). Am J Cardiovasc Drugs. 2019
Jun;19(3):299-311. doi: 10.1007/s40256-018-0313-0.
56 Hirano K, Kobayashi D, Kohtani N, Uemura Y, Ohashi Y, Komatsu Y, Yanagita M, Hishida A.
Optimal follow-up intervals for different stages of chronic kidney disease: A prospective

observational study. Clinical and Experimental Nephrology, 2019 May;23(5):613-620. doi:
10.1007/s10157-018-01684-4.
55 Ando K, Shimada K, Yamazaki T, Uchiyama S, Uemura Y, Ishizuka N, Teramoto T, Oikawa S,
Sugawara M, Murata M, Yokoyama K, Ikeda Y, Japanese Primary Prevention Project (JPPP) Study
Group. Influence of Blood Pressure on the Effects of Low-Dose Aspirin in Elderly Patients with
Multiple Atherosclerotic Risks. Journal of Hypertension, J Hypertens. 2019 Jun;37(6):1301-1307.
doi: 10.1097/HJH.0000000000002034.
54 Sugawara K, Yamashita H, Uemura Y, Yagi K, Nishida M, Aikou S, Nomura S, Seto Y. Preoperative
lymph node status on computed tomography influences the survival of pT1b, T2 and T3 esophageal
squamous cell carcinoma. Surgery Today, 2019 May;49(5):378-386. doi: 10.1007/s00595018-1741-9.
53 Okimoto N, Uemura Y, Yoshioka T, Arita S, Tsurukami H, Otomo H, Nishida S, Ogawa T, Hirao K,
Ikeda S, Matsumoto H, Toten Y, Katae Y, Okazaki Y, Nakagawa T, Sakai A. Treatment with OnceWeekly Alendronate Oral Jelly Compared with Once-Weekly Alendronate Oral Tablet for JapanesePatients with Primary Osteoporosis: an Open-label, Prospective, Observational Study. Health Sci
Rep. 2018 Dec 12;2(1):e107. doi: 10.1002/hsr2.107. eCollection 2019 Jan.
52 Miura M, Shirai S, Uemura Y, Hayashi M, Takiguchi H, Ito S, Yano M, Kawaguchi T, Morinaga T,
Isotani A, Kakumoto S, Seo K, Arai Y, SakaguchiG, Ando K. Clinical Impact of Intraventricular
Conduction Abnormalities after Transcatheter Aortic Valve Implantation with Balloon-Expandable
Valves. American Journal of Cardiology, Am J Cardiol. 2019 Jan 15;123(2):297-305. doi:
10.1016/j.amjcard.2018.10.005.
51 Hayashi T, Uemura Y, Kumagai M, Kimpara M, Kanno H, Ohashi Y. Effect of Achieved Hemoglobin
Level on Renal Outcome in Non-dialysis Chronic Kidney Disease (CKD) Patients Receiving
Epoetin Beta Pegol: MIRcerA CLinical Evidence on Renal Survival in CKD Patients with Renal
Anemia (MIRACLE-CKD Study). Clinical and Experimental Nephrology, Clin Exp Nephrol. 2019
Mar;23(3):349-361. doi: 10.1007/s10157-018-1649-0.
50 Nakamura K, Aizawa J, Kawarada K, Uemura Y, Koyama T, Nitta O. Immediate effects of thoracic
spine self-mobilization in patients with mechanical neck pain: a randomized controlled trial. Journalof Bodywork and Movement Therapies, 2019;23(2):417-424. doi: 10.1016/j.jbmt.2018.05.008.
49 Uemura Y, Tanaka S, Miyazaki T, Tsukiyama M, Sone T, Taguchi A, Soen S, Mori S, Hagino H,
Sugimoto T, Fukunaga M, Ohta H, Nakamura T, Orimo H, Shiraki M. Study design of multi-center,
open-label randomized controlled, head-to-head trial comparing minodronic acid and raloxifene:
Japanese Osteoporosis Intervention Trial (JOINT)-04. Journal of Bone and Mineral Metabolism.,2019;37(3):491-495. doi: 10.1007/s00774-018-0942-z.
48 Naya M, Uemura Y, Matsumoto N, Momose M, Kato T, Hida S, Yamauchi T, Nakajima T, Suzuki E,
Tamaki N; J-COMPASS Extended Follow-Up Study Group. Long-term events after physician-referred initial tests by myocardial perfusion imaging or computed tomography coronary
angiography in patients with suspected coronary artery disease. Coronary Artery Disease, 2018
Nov;29(7):539-546. doi: 10.1097/MCA.0000000000000645.
47 Fujimoto C, Egami N, Kawahara T, Uemura Y, Yamamoto Y, Yamasoba T, Iwasaki S. Noisy galvanic
vestibular stimulation sustainably improves posture in bilateral vestibulopathy. Frontiers in
Neurology, 2018, doi: 10.3389/fneur.2018.00900. eCollection 2018.
46 Lee Y, Ohno T, Uemura Y, Osanai A, Miura S, Taketani T, Fukuda S, Ono M, Takamoto S. Impact ofComplete Revascularization on Long-term Outcomes after Coronary Artery Bypass Grafting in
Patients with Left Ventricular Dysfunction. Circulation Journal, 2018 Dec 25;83(1):122-129. doi:
10.1253/circj.CJ-18-0653.
45 Higashitani M, Uemura Y, Mizuno A, Utsunomiya M, Tetsuo Y, Matsui A, Ozaki S, Tobita K, Tosaka
A, Oida A, Suzuki K, Kodama T, Jujo K, Doijiri T, Takahashi Y, Matsuno S, Kaneko N, Moriguchi
A, Kishi S, Anzai H. Cardiovascular outcome and mortality in patients undergoing endovasculartreatment for symptomatic peripheral artery disease: short term results of the Toma-Code Registry.
Circulation Journal, 2018; 25;82(7):1917-1925..
44 Yamada D, Kume H, Miyazaki H, Tanaka M, Takata M, Uemura Y, Morikawa T, Enomoto Y, Suzuki
M, Nishimatsu H, Nakagawa T, Fujimura T, Fukuhara H, Igawa Y, Homma Y. A prospective
randomized controlled study on Suppression of Prostate Cancer by Naftopidil (SNAP). Preventive
Medicine and Community Health, 2018; 1(1): 1-6.
43 Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D,
Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima
I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano B, Kasai K,
Higashida H, Ozaki N, Kosaka H. Effect of intranasal oxytocin on the core social symptoms ofautism spectrum disorder: a randomized clinical trial. Molecular Psychiatry, 2018, doi:
10.1038/s41380-018-0097-2. [Epub ahead of print]
42 Matsuoka K, Uemura Y, Kanai T, Kunisaki R, Suzuki Y, Yokoyama K, Yoshimura N, Hibi T. Efficacyof Bifidobacterium breve fermented milk in maintaining remission of ulcerative colitis. Digestive
Diseases and Sciences. 2018; 63(7):1910-1919.
41 Nakayama A, Morita H, Nagayama M, Hoshina K, Uemura Y ,Tomoike H, Komuro I. The Cardiac
Rehabilitation Protects against the Expansion of Abdominal Aortic Aneurysm. J Am Heart Assoc.
2018; 27;7(5).
40 Urabe M, Hiroharu Y, Uemura Y, Tanabe A, Yagi K, Akikou S, Seto Y. Non-linear association between
long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative
resection for gastric cancer: A retrospective tetrachotomous analysis of 1335 case. Japanese Clinical
Journal of Oncology. 2018; 48(4): 343-349.
39 Kawahara T, Shimozuma K, Shiroiwac T, Hagiwarad Y, Uemura Y, Watanabe T, Taira N, Fukudac T,

Ohashi Y, Mukai H. Patient-Reported Outcome Results from the Open-Label Randomized Phase III
SELECT BC Trial Evaluating First-Line S-1 Therapy for Metastatic Breast Cancer. Oncology.
2018;94(2):107-115.
38 Shimoi T, Shimomura A, Shien T , Uemura Y, Kato H, Kitada M, Toyama T, Aihara T, Mukai H.
Open-label Phase II Study of Everolimus Plus Endocrine Therapy in Post-Menopausal Women with
ER+, HER2- Metastatic Breast Cancer. (Chloe trial). Open Access Journal of Clinical Trials. 2018;
10:13-18.
37 Sugawara K, Kawaguchi Y, Nomura Y, Kawasaki K, Uemura Y, Koike D, Nagai M, Furuya T, Tanaka
N. Perioperative Factors Predicting Prolonged Postoperative Ileus After Major Abdominal Surgery.
Journal of Gastrointestinal Surgery. 2018;22(3):508-515.
36 Hagiwara T, Shiroiwa T, Shimozuma K, Kawahara T, Uemura Y, Watanabe T, Taira N, Fukuda T,
Ohashi Y, Mukai H. Impact of Adverse Events on Health Utility and Health-related Quality of Lifein Patients Receiving First-line Chemotherapy for Metastatic Breast Cancer: Results from SELECT
BC Study. PharmacoEconomics. 2018;36(2): 215-23.
35 Takata M, Amiya E, Watanabe M, Hosoya Y, Nakayama A, Fujiwara T, Taya M, Oguri G, Hyodo K,
Takayama N, Takano N, Mashiko T, Uemura Y, Komuro I. An exploratory study on the efficacy
and safety of a BCAA preparation used in combination with cardiac rehabilitation for patients withchronic heart failure. BMC Cardiovascular Disorders. 2017; 27;17(1):205..
34 Sugawara K, Yamashita H, Uemura Y, Mitsui T, Yagi K, Nishida M, Aikou S, Mori K, Nomura S,
Seto Y. Numeric pathologic lymph node classification shows prognostic superiority to topographic
pN classification in esophageal squamous cell carcinoma. Surgery. 2017; 162(4):846-856.
33 Nakagawa T, Komemushi Y, Kawai T, Otsuka M, Miyakawa J, Uemura Y, Kanatani A, Taguchi S,
Naito A, Suzuki M, Nishimatsu H, Hirano Y, Tanaka Y, Matsumoto A, Miyazaki H, Fujimura T,
Fukuhara F, Kume H, Igawa Y, Homma Y. Efficacy of post-nephroureterectomy cisplatin-based
adjuvant chemotherapy for locally advanced upper tract urothelial carcinoma: a multi-institutional
retrospective study. World Journal of Urology. 2017; 35(10): 1569-75.
32 Miura M, Shirai S, Uemura Y, Jinnouchi H, Morinaga T, Isotani A, Watanabe S, Hayashi M, Kamioka
N, Nagasawa A, Kakumoto K, Seo K, Arai Y, Hanyu M, Ando K. Early safety and efficacy oftranscatheter aortic valve implantation for Asian nonagenarians (from KMH Registry). International
Heart Journal. 2017;58(6): 900-7.
31 Watanabe T, Kuranami M, Inoue K, Masuda N, Aogi K, Ohno S, Iwata H, Mukai H, Uemura Y,
Ohashi Y. Comparison of AC-taxane vs. AC-free regimen and Paclitaxel vs. Docetaxel in NodePositive Breast Cancer Patients -Final Results of the N-SAS BC (National Surgical Adjuvant Studyof Breast Cancer) 02 Trial, a Randomized Comparative Phase 3 Study. Cancer. 2017; 123(5): 75968.
30 Tsuruya K, Uemura Y, Hirakata H, Kitazono T, Tsubakihara Y, Suzuki M, Ohashi Y. Association

between responsiveness to methoxy polyethylene glycol-epoetin beta and renal survival in patientswith non-dialysis-dependent chronic kidney disease: a pooled analysis of individual patient-level
data from clinical trials. Nephrology. 2017;22(10):769-775.
29 Tanaka S, Miyazaki T, Uemura Y, Miyakawa N, Gorai I, Nakamura T, Fukunaga M, Ohashi Y, Ohta
H, Mori S, Hagino H, Hosoi T, Sugimoto T, Itoi E, Orimo H, Shiraki M. Comparison of concurrent
treatment with vitamin K2 and risedronate compared with treatment with risedronate alone inpatients with osteoporosis: Japanese Osteoporosis Intervention Trial-03. Journal of Bone andMineral Metabolism. 2017;25(4): 385-95.
28 Nakagawa T, Taguchi S, Uemura Y, Kanatani A, Ikeda M, Matsumoto A, Yoshida K, Kawai T, Nagata
M, Komemushi Y, Suzuki M, Enomoto Y, Nishimatsu H, Ishikawa A, Nagase Y, Kondo Y, Tanaka Y,
Okaneya T, Hirano Y, Minowada S, Shinohara M, Miyazaki H, Fujimura T, Fukuhara H, Kume H,
Igawa Y, Homma Y. Nomogram for Predicting Survival of Metastatic Urothelial Carcinoma of theBladder after Radical Cystectomy. Urologic Oncology. 2017;35(7): 457.e-15-457. E21.
27 Watanabe Y, Akizawa T, Saito A, Gejyo F, Suzuki M, Nishizawa Y, Tomino Y, Tsubakihara Y, Akiba
T, Hirakata H, Kawanishi H, Bessho M, Udagawa Y, Aoki K, Uemura Y, Ohashi Y, the Co-JET
Study Group. Effect of predialysis recombinant human erythropoietin on early survival after
hemodialysis initiation in patients with chronic kidney disease: Co-JET study. Therapeutic
Apheresis and Dialysis. 2016;20(6): 598-607.
26 Ueda K, Kasao M, Shimamura, M, Haruta H, Nitta S, Kaneko M, Uemura Y, Morita H, Komuro I,
Shirai T. Impact of Oral Treatment on Physical Function in Older Patients Hospitalized for Heart
Failure: A Randomized Clinical Trial. Plos One. 2016;11(12): e0167933.
25 Fujimoto C, Yamamoto Y, Kamogashira T, Kinoshita M, Egami N, Uemura Y, Togo F, Yamasoba T,
and Iwasaki S. Noisy galvanic vestibular stimulation induces a sustained improvement in bodybalance in elderly adults. Scientific Reports. 2016;6:37575.
24 Akizawa T, Tsubakihara Y, Hirakata H, Watanabe Y, Hase H, Nishi S, Babazono T, Kumagai M,
Katakura S, Uemura Y, Ohashi Y; JET-STREAM Study Group. A prospective observational studyof early intervention with erythropoietin therapy and renal survival in non-dialysis chronic kidneydisease patients with anemia: JET-STREAM Study. Clinical and Experimental Nephrology.
2016;20(6): 885-95.
23 Miura M, Yamasaki M, Uemura Y, Yoshikawa M, Miyauchi K, Tanaka H, Miyachi H, Yamashita J,
Suzuki M, Yamamoto T, Nagao K, Komuro I, Takayama M. Effect of Statin Treatment and LowDensity Lipoprotein-Cholesterol on Short-Term Mortality in Acute Myocardial Infarction Patients
Undergoing Primary Percutaneous Coronary Intervention - Multicenter Registry From Tokyo CCU
Network Database. Circulation Journal. 2016;80(2):461-8.
22 Taguchi S, Nakagawa T, Uemura Y, Matsumoto A, Nagase Y, Kawai T, Tanaka Y, Yoshida K,
Yamamoto S, Enomoto Y, Nose Y, Sato T, Ishikawa A, Fujimura T, Fukuhara H, Kume H, Homma

Y. Validation of major prognostic models for metastatic urothelial carcinoma using a multiinstitutional cohort of the real world. World Journal of Urology. 2016 Feb;34(2):163-71.
21 Taguchi S, Nakagawa T, Matsumoto A, Nagase Y, Kawai T, Tanaka Y, Yoshida K, Yamamoto S,
Enomoto Y, Nose Y, Sato T, Ishikawa A, Uemura Y, Fujimura T, Fukuhara H, Kume H, Homma Y.
Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of survival in patients withmetastatic urothelial carcinoma: A multi-institutional study. International Journal of Urology,
2015;22(7):638-43.
20 Ko T, Higashitani M, Sato A, Uemura Y, Norimatsu T, Mahara K, Takamisawa I, Seki A, Shimizu J,
Tobaru T, Aramoto H, Iguchi N, Fukui T, Watanabe M, Nagayama M, Takayama M, Takanashi S,
Sumiyoshi T, Komuro I, Tomoike H. Impact of Acute Kidney Injury on Early to Long-Term
Outcomes in Patients Who Underwent Surgery for Type A Acute Aortic Dissection. American
Journal of Cardiology. 2015 Aug 1;116(3):463-8.
19 Uemura Y, Miyakawa N, Orimo H, Shiraki M, Nakamura T, Mori S. Comparison of expert andnonexpert physicians in the assessment of vertebral fractures using the semiquantitative method inJapan. Journal of Bone and Mineral Metabolism, 2015; 33(6):620-50.
18 Akizawa T, Saito A, Gejyo F, Suzuki M, Nishizawa Y, Tomino Y, Tsubakihara Y, Akiba T, Hirakata H,
Watanabe Y, Kawanishi H, Bessho M, Udagawa Y, Aoki K, Uemura Y, Ohashi Y, and the JET Study
Group. Low hemoglobin levels and hypo-responsiveness to erythropoiesis-stimulating agent
associated with poor survival in incident Japanese hemodialysis patients. Therapeutic Apheresis
and Dialysis.2014; 18(5):404-13.
17 Ohta H, Uemura Y, Nakamura T, Fukunaga M, Ohashi Y, Hosoi T, Mori S, Sugimoto T, Itoi E, Orimo
H, Shiraki M, for the Adequate Treatment of Osteoporosis (A-TOP) Research Group. Serum 25hydroxyvitaminD level as an independent determinant of quality of life in osteoporosis with a highrisk for fracture. Clinical Therapeutics. 2014; 36(2): 225-35.
16 Ito S, Uenishi K, Ishida H, Uemura Y, Kodama M, Fukuoka H. Relationships between birth weightand serum cholesterol levels in 2 healthy Japanese late adolescents. Journal of Nutritional Science& Vitaminology.2014; 60(2):108-13.
15 Akizawa T, Saito A, Gejyo F, Suzuki M, Nishizawa Y, Tomino Y, Tsubakihara Y, Akiba T, Hirakata
H, Watanabe Y, Kawanishi H, Bessho M, Udagawa Y, Aoki K, Uemura Y, Ohashi Y, and the CoJET Study Group. Impacts of recombinant human erythropoietin treatment during predialysis
periods on the progression of chronic kidney disease in a large-scale cohort study (Co-JET study).
Therapeutic Apheresis and Dialysis. 2014; 18(2): 140-8.
14 Tanaka S, Miyazaki T, Uemura Y, Kuroda T, Miyakawa N, Nakamura T, Fukunaga M, Ohashi Y, Ohta
H, Mori S, Hagino H, Hosoi T, Sugimoto T, Itoi E, Orimo H, Shiraki M. Design of a randomized
clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone
in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03). Journal

of Bone and Mineral Metabolism. 2014; 32(3): 298-304.
13 Fujita R, Iimuro S, Shinozaki T, Sakamaki K, Uemura Y, Takeuchi A, Matsuyama Y, Ohashi Y..
Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk.
A multicenter, double-blinded, randomized comparative study in users of daycare facilities for theelderly.American Journal of Infection Control. 2013; 41(12):1231-5.
12 Ohashi Y, Uemura Y, Fujisaka Y, Sugiyama T, Ohmatsu H, Katsumata N, Okamoto R, Saijo N, Hotta
T. Meta-analysis of epoetin beta and darbepoetin alfa treatment for chemotherapy-induced anemia
and mortality: Individual patient data from Japanese randomized, placebo-controlled trials. Cancer
Sciene 2013;104(4):481-5.
11 Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C. Executive function
deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via
lactation. PLoS One 2012;7(12):e50741.
10 Yamauchi T, Tamaki N, Kasanuki H, Kimura T, Uemura Y, Iimuro S; Japanese CoronaryAngiography or Myocardial Imaging for Angina Pectoris Study (J-COMPASS) Multicenter Study
Group. Optimal initial diagnostic strategies for the evaluation of stable angina patients: a multicenter,
prospective study on myocardial perfusion imaging, computed tomographic angiography, andcoronary angiography. Circulation Journal. 2012;76(12):2832-9.
9 Sawaki M, Mukai H, Tokudome N, Nakayama T, Taira N, Mizuno T, Yamamoto Y, Horio A, Watanabe
T, Uemura Y, Ohashi Y. Safety of adjuvant trastuzumab for HER2-overexpressing elderly breast
cancer patients: a multicenter cohort study. Breast Cancer 2012 ;19(3):253-8.
8 Isono W, Nagamatsu T, Uemura Y, Fujii T, Hyodo H, Yamashita T, Kamei Y, Kozuma S, Taketani Y..
Prediction model for the incidence of emergent cesarean section during induction of labor
specialized in nulliparous low-risk women. Journal of Obstetrics and Gynaecology Research 2011:37(12); 1784-91.
7 Chiba Y, Taguri M, Uemura Y. On the identification of the survivor average causal effect. Journal of
Biometrics and Biostatistics 2011;2:e104.
6 Sawaki M, Tokudome N, Mizuno T, Nakayama T, Taira N, Bando H, Murakami S, Yamamoto Y,
Kashiwaba M, Iwata H, Uemura Y, Ohashi Y. Evaluation of trastuzumab without chemotherapy as
a post-operative adjuvant therapy in HER2-positive elderly breast cancer patients: randomized
controlled trial [RESPECT (N-SAS BC07)]. Japanese Clinical Journal of Oncology
2011;41(5):709-12.
5 Orimo H, Nakamura T, Fukunaga M, Ohta H, Hosoi T, Uemura Y, Kuroda T, Miyakawa N, Ohashi Y,
Shiraki M; A-TOP (Adequate Treatment of Osteoporosis) research group. Effects of alendronate plus
alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis
Intervention Trial (JOINT)_02. Current Medical Research & Opinion 2011;27:1273-84.
4 Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K,

Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M. Automated test of behavioral flexibility inmice using a behavioral sequencing task in IntelliCage. Behavioural Brain Research
2011;221(1):172-81.
3 Kurita M, Okazaki M, Ozaki M, Tanaka Y, Tsuji N, Takushima A, Harii K. Patient satisfaction after
open reduction and internal fixation of zygomatic bone fractures. Journal of Craniofacial Surgery
2010;21:1-5.
2 Kurita M, Ichioka S, Tanaka Y, Umekawa K, Oshima Y, Ohura N, Kinoshita M, Harii K. Validity oforthopedic POSSUM scoring system for the assessment of postoperative mortality in patients withpressure ulcers. Wound Repair and Regeneration 2009; 17: 312-7.
1 Tanaka Y, Matsuyama Y, Ohashi Y. for the MEGA Study Group. Estimation of treatment effectadjusting for treatment changes using the intensity score method: application to a large primaryprevention study for coronary events (MEGA study). Statistics in Medicine 2008;27:1718-33.

＜Letter＞
1.

Shimoda, M., Chujo, D., Kurokawa, T., Kawabe, A., Takahashi, N., Ito, K., Maruyama, K., Shinohara,
K., Ajima, K., Sugahara, Y., Takaki, T., Kajio, H., Yanase, M., Hinohara, C., Tokuhara, M., Uemura,Y., Edamoto, Y., Takemura, N., Matsumoto, S., & Kokudo, N. (2021). Efficacy and safety of total
pancreatectomy with islet autotransplantation: A clinical study in Japan. Journal of diabetes, 13(11),940–942. https://doi.org/10.1111/1753-0407.13218＜Commentary＞
1.

Uemura Y, Shinozaki T, Nomura S, Shibata T. Comment on “Biostatistical Considerations When
Using RWD and RWE in Clinical Studies for Regulatory Purposes: A Landscape Assessment”.
Statistics in Biopharmaceutical Research, DOI:10.1080/19466315.2021.1974537