268

IMSUT Hospital

Department of Surgery
外科Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor

Dai Shida, M.D., Ph.D.
Susumu Aiko, M.D., Ph.D.
Yuka Ahiko, M.D.
Naoki Sakuyama, M.D.
Haruna Onoyama, M.D.
Satoko Monma, M.D.
Shigehiro Kojima, M.D.

教 授
准教授助 教助 教助 教助 教助 教博士（医学）
博士（医学）
博士（医学）
博士（医学）
博士（生命医科学）

志 田
愛 甲阿 彦柵 山小野山門 間小 島友尚温聡成大丞佳紀那子浩

The mission of our department is to provide surgical treatment for various
gastrointestinal diseases, such as colorectal cancers and gastric cancers. Since
the participation of Prof. Shida and Dr. Ahiko in September 2020, we mainly
perform laparoscopic surgery instead of open surgery for these diseases. Inaddition, we started robotic surgery for rectal cancer in April, 2021. This year, we
also started robotic surgery for colon cancer in September, 2022.

1.  Introduction
We specialize in the treatment of gastrointestinal
cancers, especially surgical treatment of colorectal
cancer and gastric cancer. Colorectal cancer can becompletely cured by more than 70% of patients whenappropriate surgery is performed, even if it is stage III
cancer. As qualified surgeons (endoscopic surgicalskill qualification system) of the Japan Society for Endoscopic Surgery (Dr. Shida, Dr. Aiko and Dr. Kojima) as well as qualified console surgeon of roboticsurgery (da Vinci system) (Dr. Shida, Dr. Aiko, Dr.
Ahiko, Dr. Sakuyama, Dr. Onoyama, Dr. Kojima, andDr. Monma), we are actively performing minimallyinvasive surgery with less physical burden of patients. In addition, after Dr. Kojima joined us, we also
started laparoscopic surgery for inguinal hernia. All
the staff do their best to treat the patients.
2.  Treatment for gastrointestinal malignancy
Colorectal cancers and gastric cancers are what wemainly treat. For rectal cancer, in order to improve theQOL (quality of life) after surgery as much as possible, we select not only autonomic nerve-sparing surgery but also anus-sparing surgery if the cancer canbe sufficiently resected. For gastric cancer, we selectthe surgical method with policy of ‘leaving the remaining stomach as much as possible’, because stomach surgery limits the amount of food that patients
eat after surgery which leads to weight loss and weakness. As qualified surgeons (endoscopic surgical skill
qualification system) of the Japan Society for Endoscopic Surgery (Dr. Shida, Dr. Aiko and Dr. Kojima),
we are actively performing minimally invasive surgery, that is, laparoscopic surgery and robotic surgery.
3.  Surgical treatment for inguinal hernia
We started laparoscopic surgery for inguinal hernia in October, 2022. Our method is totally extra-peritoneal inguinal hernia repair (TEP), which is an effective minimally invasive method for treating hernias

269that avoids entry into the abdomen.
4.  Surgical treatment for other benign diseases
We also treat a variety of benign diseases such asacute appendicitis, cholecystitis, and colonic diverticulitis.
5.  Endoscopic examination and treatment
Under cooperation with Department of General

Medicine (Prof. Boku N., Dr. Matsubara Y., Dr. Hirata
Y. and Dr. Baba K.), we performed many cases of upper gastrointestinal endoscopy and colonoscopy.
6. Launch of Robotic Surgery
We started robotic rectal surgery for rectal tumors
such as rectal cancer and rectal NET (neuroendocrinetumor) in April, 2021. We also started robotic surgeryfor colon cancer in September, 2022.

Publications
Refractory Intestinal Behçet-Like Disease Associatedwith Trisomy 8 Myelodysplastic Syndrome Resolved by Parenteral Nutrition.
Takahashi R, Matsubara Y, Takahashi S, Yokoyama
K, Ahyoung LL, Koga M, Sakamoto H, Boku N,
Shida D, Yotsuyanagi H.
Case Rep Gastroenterol. 2023 Oct 11;17(1):287-293.
Prognostic factors associated with the transition intreatment methods for brain metastases fromcolorectal cancer.
Imaizumi J, Shida D, Boku N, Igaki H, Itami J, Miyakita Y, Narita Y, Takashima A, Kanemitsu Y.
Int J Clin Oncol. 2023 Aug;28(8):1043-1053.
Genomic landscape and its prognostic significance instage III colorectal cancer: JCOG1506A1, an ancillary of JCOG0910.
Shida D, Kuchiba A, Shibata T, Hamaguchi T,
Yamasaki S, Ito M, Kobatake T, Tonooka T, MasakiT, Shiozawa M, Takii Y, Uetake H, Okamura S, Ojima H, Kazama S, Takeyama H, Kanato K, ShimadaY, Murakami Y, Kanemitsu Y.
Cancer Sci. 2023 Aug;114(8):3352-3363.
Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a
TIP60-independent regulation of the pre-RC complex.
Yamaguchi K, Nakagawa S, Saku A, Isobe Y, Yamaguchi R, Sheridan P, Takane K, Ikenoue T, Zhu C,
Miura M, Okawara Y, Nagatoishi S, Kozuka-Hata
H, Oyama M, Aikou S, Ahiko Y, Shida D, Tsumoto
K, Miyano S, Imoto S, Furukawa Y.
iScience. 2023 Apr 1;26(4):106563.
Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts.
Ito T, Takayanagi D, Sekine S, Hashimoto T, Shimada Y, Matsuda M, Yamada M, Hamamoto R, Kato T,
Shida D, Kanemitsu Y, Boku N, Kohno T, Takashima A, Shiraishi K.
Sci Rep. 2023 Mar 3;13(1):3587. doi: 10.1038/s41598023-30624-w.
Effect of Biologics on the Risk of Advanced-Stage Inflammatory Bowel Disease-Associated Intestinal
Cancer: A Nationwide Study.

Seishima R, Okabayashi K, Ikeuchi H, Uchino M,Futami K, Noguchi T, Ohge H, Iseki Y, Watanabe K,Itabashi M, Okamoto K, Toiyama Y, Ogino T, Nakamura M, Yamada K, Wakai T, Sato Y, Kimura H,Takahashi K, Hida K, Kinugasa Y, Ishida F, Okuda
J, Daito K, Koyama F, Ueno H, Yamamoto T,Yamamoto S, Hanai T, Maemoto A, Arakaki J, Komori K, Akagi Y, Shida D, Yamaguchi S, Matsuda K,Maeda K, Noake T, Nezu R, Sasaki S, Hasegawa J,Sunami E, Kanemitsu Y, Katsumata K, Uehara K,Kiyomatsu T, Suto T, Kazama S, Yamada T, Goi T,Ishihara S, Ajioka Y, Sugihara K.
Am J Gastroenterol. 2023 Jul 1;118(7):1248-1255.
Prognostic differences between oligometastatic andpolymetastatic disease after resection in patientswith colorectal cancer and hepatic or lung metastases: Retrospective analysis of a large cohort at a single institution.
Horie T, Kanemitsu Y, Takamizawa Y, Moritani K,
Tsukamoto S, Shida D.
Surgery. 2023 Feb;173(2):328-334.
Identification of odontogenic ameloblast associatedas a novel target gene of the Wnt/β-catenin signaling pathway.
Yamaguchi K, Horie C, Takane K, Ikenoue T, Nakagawa S, Isobe Y, Ota Y, Ushiku T, Tanaka M, Fujishiro J, Hoshino N, Arisue A, Nishizuka S, Aikou
S, Shida D, Furukawa Y.
Cancer Sci. 2023 Mar;114(3):948-960.
Risk of non-colorectal cancer-related death in elderly
patients with the disease: A comparison of five preoperative risk assessment indices.
Yasui K, Shida D, Ahiko Y, Takamizawa Y, Moritani
K, Tsukamoto S, Kanemitsu Y.
Cancer Med. 2023 Feb;12(3):2290-2302.
Prognostic Role for Primary Tumor Location in Patients With Colorectal Liver Metastases: A Comparison of Right-Sided Colon, Left-Sided Colon, andRectum.
Takamizawa Y, Shida D, Horie T, Tsukamoto S, Esaki M, Shimada K, Kondo T, Kanemitsu Y.
Dis Colon Rectum. 2023 Feb 1;66(2):233-242.
Prognostic Factors of Bone Metastases From Colorectal Cancer in the Era of Targeted Therapy.

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Kobayashi Y, Shida D, Boku N, Yasui K, Nakamura
Y, Kudose Y, Imaizumi J, Kanemitsu Y.
Dis Colon Rectum. 2023 Mar 1;66(3):401-409.
Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction
cancer not treated with neoadjuvant chemotherapy.
Shiomi S, Yagi K, Iwata R, Yajima S, Okumura Y,Aikou S, Yamashita H, Nomura S, Seto Y.
Surg Endosc. 2023 Nov;37(11):8214-8226.
Utility of the revised FIGO2023 staging with molecular classification in endometrial cancer.
Kobayashi-Kato M, Fujii E, Asami Y, Ahiko Y, Hiranuma K, Terao Y, Matsumoto K, Ishikawa M,Kohno T, Kato T, Shiraishi K, Yoshida H.
Gynecol Oncol. 2023 Nov;178:36-43.
Artificial intelligence for the recognition of key anatomical structures in laparoscopic colorectal surgery.
Kitaguchi D, Harai Y, Kosugi N, Hayashi K, Kojima
S, Ishikawa Y, Yamada A, Hasegawa H, Takeshita
N, Ito M.
Br J Surg. 2023 Sep 6;110(10):1355-1358.
Automatic Surgical Skill Assessment System Based on
Concordance of Standardized Surgical Field Development Using Artificial Intelligence.
Igaki T, Kitaguchi D, Matsuzaki H, Nakajima K,Kojima S, Hasegawa H, Takeshita N, Kinugasa Y,Ito M.
JAMA Surg. 2023 Aug 1;158(8):e231131. doi:
10.1001/jamasurg.2023.1131. Epub 2023 Aug 9.
Deep-learning-based semantic segmentation of autonomic nerves from laparoscopic images of colorectal surgery: an experimental pilot study.
Kojima S, Kitaguchi D, Igaki T, Nakajima K, Ishikawa Y, Harai Y, Yamada A, Lee Y, Hayashi K, Kosugi
N, Hasegawa H, Ito M.
Int J Surg. 2023 Apr 1;109(4):813-820.
Universal meta-competencies of operative performances: a literature review and qualitative synthesis.
Igaki T, Takenaka S, Watanabe Y, Kojima S, Nakajima K, Takabe Y, Kitaguchi D, Takeshita N, Inomata
M, Kuroyanagi H, Kinugasa Y, Ito M.
Surg Endosc. 2023 Feb;37(2):835-845.
Assessment of Elastic Laminal Invasion Contributes
to an Objective pT3 Subclassification in Colon Cancer.
Kojima M, Yokota M, Yanagisawa N, Kitamura S,Amemiya K, Kawano S, Tsukada Y, Sakuyama N,Nagayasu K, Hashimoto T, Nakashima K, Jiang K,Kanemitsu Y, Fujita F, Akiba J, Notohara K, Itakura
J, Sekine S, Sakashita S, Sakamoto N, Ishikawa S,
Nakanishi Y, Yao T, Liang WY, Lauwers GY, Ito M,Sakamoto K, Ishii G, Ochiai A.
Am J Surg Pathol. 2023 Oct 1;47(10):1122-1133.