FINANCIAL REPORTWHO IS BEHIND THE FOUNDATIONThe ZOLL Foundation financial status at March 31,2018 was as follows: The Foundation had assets ofapproximately $13 million. Additional contributions
from ZOLL Medical, Asahi Kasei, and other potential
donors are expected to be added to the Foundation’s
assets through 2020, allowing for expansion of grants as
the Foundation’s assets increase.

BOARD OF DIRECTORSThe Foundation has provided $718,748 in funding
support to investigators since it began supporting researchin resuscitation and acute critical care on a global basis.
Average grants range from $10,000–$50,000 dependingon scale and duration of the research.

WHAT AND HOW
During the reporting period the Foundation
implemented a new on-line program for applicants
to use to apply for support, receive confirmation ofsubmissions, complete application requirements, andupload professional information and the supporting
information useful in describing anticipated research.
The Foundation also established a twice a year
application deadline and approval/review schedule togive applicants a better tool for planning submissions,
understanding prospective approval dates, andplanning their work if approved. The online system
also supports convenient Board review of applications
and supporting materials.
Applications for support can be made through theFoundation website, www.zollfoundation.org, which
publicizes the Foundation’s purposes and grants. The
application process is designed to be fairly simple.
There are two deadlines each year, March 31 andSeptember 30, with awards being made aroundMay 31 and November 30, respectively. The Board
meets two times a year to review grant applications
and conduct Foundation business. Grantees agree
to certain stipulations about the administration of
the grant, provide yearly reports about the use of thegrant funds, and a final report related
to their work when completed.
Grants are typically made to
the institution the grantee
is affiliated with, inaccordance with rules
governing 501(c)(3)organizations,and earmarked fortheir work.

The Board is very privileged to have Dr. Norman Paradis asa member lending scientific expertise to the Board’s reviewof applications. He is a visiting Professor of Medicine, Geisel
School of Medicine Dartmouth College, and Clinical Associate
Professor of Emergency Medicine, Keck School of Medicine at
the University of Southern California. He is also an AttendingPhysician at Dartmouth Hitchcock Hospital in Lebanon, New
Hampshire, and LAC-USC Medical Center, Los Angeles,California. Board Certified in Emergency Medicine, Dr. Paradis isa highly respected resuscitation scientist and physician.
Ms. Coreen M. Packer, Trustee of the Packer Family Trust,also serves on the Board as an outside director.
Mr. Ward Hamilton, retired from ZOLL Medical after 25 years,
was named President of the Foundation in January 2018.
Mr. Richard Packer, former Foundation President, replaced
Hamilton as Clerk; he is Chairman of ZOLL Medical and Primary
Executive Officer of Asahi Kasei HealthCare.
Mr. John Bergeron, semi-retired from ZOLL, continues
as Treasurer.
No directors receive any compensation and all serve voluntarily.

ADMINISTRATIONMs. Susan Schumacher, a Senior Director in Marketing atZOLL, is Administrator.
The Foundation’s Counsel Alyssa C. Fitzgerald, Esq. ofGoodwin Proctor LLP, Boston, Massachusetts.

THANK YOUThe Foundation acknowledges and thanks the many
researchers who have submitted applications andhelped to establish this foundation’s activities. We
regret we are not able fund all applicants.
The Foundation also acknowledges and thanks
the organizations and individuals who have andcontinue to contribute to the Foundation. Thesecontributions have ensured sufficient resources
to pursue the goals we established in
the formation of the organization.

ZOLL FOUNDATION • 269 MILL RD, CHELMSFORD MA 01824 • WWW.ZOLLFOUNDATION.ORG

ZOLL FOUNDATIONACTIVITIES REPORTA P R I L 2 016 – M A RC H 2 018

In addition to successfullycompleting and publishing ourproject, the data supported bythis grant were foundational
preliminary data for asubsequently funded 5-year
K23 career development award
that builds our work here.
Jonathan Elmer, M.D., Assistant Professor,Departments of Emergency Medicine, Critical Care
Medicine and Neurology, University of Pittsburgh.
2014 ZOLL Foundation grant recipient for research
entitled, “Swine model of multimodal neurologicalmonitoring and goal-directed treatment after
cardiac arrest.”

The ZOLL Foundation was established in 2013 by ZOLL Medical Corporation,
an Asahi Kasei Group Company, as a Massachusetts non-profit charitableorganization to promote research in resuscitation and acute critical care.

The Foundation qualifies as tax-exempt under theUnited States Internal Revenue Code Section 501(c)(3). Contributions to the Foundation are tax-deductible
under Section 170 of the Code. The Foundation is also
registered as a non-profit charity with the Office of theAttorney General for the Commonwealth of Massachusetts.
As a non-profit organization, the Foundation can accept
tax-deductible contributions from individuals. As a privatefoundation, it can make grants to other organizationsclassified as 501(c)(3) public charities or private foundations;foreign organizations whose activities are in furtherance ofthe foundation’s charitable purposes; and individuals whomeet grant eligibility criteria.
The Foundation’s purposes have been supported bysubstantial donations from ZOLL Medical Corporation,Asahi Kasei, The Packer Family Trust, donations
from ZOLL executives and employees, and ongoing
contributions from members of the ZOLL and Asahi
Kasei Group companies.
The Foundation exists as an independent entity from ZOLL
Medical Corporation, with a separate Board of Directors,
including two outside directors who are not ZOLL
employees, and two directors who are ZOLL retirees.
It is the Foundation’s primary purpose to provide grants
targeted at new research, new researchers, and new ideas
in education and public awareness related to improvingresuscitation practices, preventing patient deterioration withassociated cardiac arrest and morbidity, and enhancing thecare of acute patients to reduce mortality and morbidity.
By Board determination, grants provided focus on getting
new ideas started, providing “seed money” to help stimulateinterest in the field, and attracting young investigators to
the public health problems of sudden death,acute critical care, and improving postresuscitation care.
The Board is oriented toproviding support to applicants
through smaller grants, incontrast to a single or a few largegrants for major studies. It is the Board’s objective that
support of early ideas and new professionals interested inresuscitation will both motivate recipients to focus theircareers on improving resuscitation and critical care, andalso allow them to attract additional support and funding
for additional studies, if promising, based on the early work
funded by the ZOLL Foundation.
The activities of the Foundation are governed by by-laws on
file with the Secretary of State for the Commonwealth of
Massachusetts. The Foundation has a policy to not provide
grants that include amounts for institutional overhead. TheFoundation adheres to policies covering conflict of interest,grant-making procedures, and records retention. Grants
to organizations outside of the United States are subject tochecks related to foreign entities necessary to maintain theFoundation’s 501(c)(3) status as a charitable organization.
The Foundation’s fiscal year ends on March 31 of each year.
The Board has also adopted a policy to not support research
directly related to ZOLL Medical products or Asahi Kasei
medical products to avoid potential conflict-of-interest issues
related to the Foundation’s charitable status. The incidental
use of ZOLL products in research funded by the Foundation
will be reviewed by the Board, and will be allowed if such
use is in its entirety incidental to the purpose for which theresearch is being performed.
To keep all contributors and interested parties informed
about the Foundation’s activities and help applicants withinformation related to approved projects, the Foundationis committed to publishing reports on an annual or otherappropriate periodic basis reviewing the support it hasprovided in accordance with the purposes for which it
was established.
The ZOLL Foundation’s first report was provided in
an Annual Report that covered activities throughMarch 31, 2016, 30 months after the foundation wasdeemed a tax-exempt, non-profit organization on
September 10, 2013. This report covers the period
from April 2016 until March 2018.

GRANT OUTCOMES*
Those awarded grants are required to submit an annual progress
report. Seed grants can often be the catalyst for significant newwork and the results yielded can be the stimulus for additional
research and funding. The Foundation’s grants are intended fornewer investigators around the globe who have the potential
to make a big impact on their field of research, especiallyresuscitation and acute critical care. In addition, we are mindfulof the exposure of the research through scientific assemblies
and publications, which have the means to stimulate further
interest in research in the field and drive applications from others
interested in support from the ZOLL Foundation. Applications
for funding support have grown as the Foundation’s activities
have become more prominent. We believe this will stimulate
more applications, making for a more highly competitive process.
Additionally, the amount of funding available is also increasing, as
more donations increase the Foundation’s resources.
We are pleased to add two excerpts from final reports provided
by two of our earlier grantees. Their results are indicative of
how meaningful a modest grant from the ZOLL Foundation
can be in advancing research and the careers of new researchers
in resuscitation and acute critical care.
Aaron Donahue, M.D., one of first to be awarded aFoundation grant in 2014, is Associate Professor of Critical
Care Medicine and Pediatrics, Perelman School of Medicine
at the University of Pennsylvania, in addition to being anAttending Physician in the Division of Critical Care Medicineand Emergency Medicine at Children’s Hospital of Philadelphia(CHOP). His research, conducted with Benjamin Kerrey,
MD, and Karen O’Connell, M.D., is entitled, “Videography
in Pediatric Emergency Research: Establishing a Multicenter
Collaborative and Resuscitation Registry.” In the period
covering the grant funding – 2015 to 2017 – the project
achieved all goals established in the original proposal. These
milestones were: 1) Creating a data registry to be populated
from video review of pediatric resuscitation events in threetertiary pediatric emergency departments; 2) Completing
feasibility and reliability testing using simulated resuscitations
under video recorded conditions, and 3) Going live with actual
patient cases late in 2016 after IRB approvals from two of threecenters, with the third pending.
Dr. Donahue’s and colleagues’ preliminary research results
were presented at a number of respected meetings, including

the Eastern Society for Pediatric Research in Philadelphia,
the International Pediatric Simulation Symposium andWorkshop in Glasgow, the annual meeting of the PediatricAcademic Societies in Baltimore, and the American Heart
Association Resuscitation Science Symposium in New Orleans.
Additionally, a peer-reviewed manuscript was acceptedfor publication in Pediatric Emergency Care, with a second
manuscript in preparation. And finally, a favorable score wasreceived on an application for NIH funding through NICHD.
Timothy C. Y. Chan, PhD, was awarded a grant in 2015
for his research on “Optimizing public access defibrillation
deployment incorporating hours of operation.” At theUniversity of Toronto, he is Canada Research Chair in Novel
Optimization and Analytics in Health; Associate Professor,
Mechanical and Industrial Engineering; and Director, Centre
for Healthcare Engineering. With the support of the ZOLL
Foundation funding, a novel spatiotemporal model to optimize
the deployment of AEDs in both space and time was designed.
AED locations were determined by considering estimates ofboth geographical and time-of-day risk for out-of-hospital
cardiac arrest (OHCA). Data collected on hours of operationof public buildings and businesses in Toronto enabled asecond study to characterize the spatiotemporal risk of OHCA
in different location types in Toronto. Being able to rankbusinesses and other location types according to a novel risk
measure will serve as a guide for public-private partnership in
public access defibrillator deployment.
The initial project resulted in two high-impact papers thatdescribe the findings of the two studies. A paper on thespatiotemporal optimization study was published in the Journalof the American College of Cardiology in 2016 (Sun et al., 2016).
A subsequent paper classifying spatiotemporal risk of different
location types was accepted in Circulation for publication inSpring 2017 (Sun et al., 2017). The 2016 publication attracted
substantial attention by other media, including CardiovascularBusiness, Reuters, Global News, The Globe and Mail, Huffington
Post, Science Daily, and US News & World Report Online.
The rising profile of Dr. Chan importantly attracted otherresearch groups and knowledge users as ongoing research andimplementation partners, including the Copenhagen project
and the University of Toronto.
* Please note that information shared is what was provided in a grantee’s annual or final
report. It represents only the latest information provided to the Foundation, but may
not be the most final information available.

Thanks to the ZOLL Foundation, we can for the first time ever, look at
the issue of cardiac arrests from a regional perspective in the Middle East.
Allan Batt, M.D., Associate Professor, Fanshawe College. A 2018 ZOLL Foundation grant recipient proposing to conduct ascoping review of existing studies on OHCA in the Arabian Gulf to guide development of manuscripts or policies, as well
as strengthen and aid future research on this issue in the region.

SUMMARY OF GRANTS

2019

Since its inception through June 2019, the Foundation has awarded over $1,000,000 in grants to 37 recipients.
GRANT TITLE

INSTITUTION

COUNTRY

LEAD RESEARCHER

Investigate the effects of WIN55, 212-2 on CB2 receptors following cardiopulmonary resuscitation.

Virginia Commonwealth
UniversityUnited StatesJennifer Bradley, MS, CRA

Compare personalized selection of an optimal MAP to each patient versus standard
hemodynamic management with all having same BP goal

University of Pittsburgh
School of Medicine

United States

Patrick Coppler, PA-C

Aim to improve initial & long-term survival & diminish neurological damage after
global ischemia & reperfusion by administration of Hemarina-M101 after CA

Inselspital Bern
University Hospital

Switzerland

Michael Glas, Dr. Medicine

Hypothesize that CPR augmented by balloon aortic occlusion benefits from adaptive
balloon-wealing protocol tailored to maintain a blood pressure

Travis Air Force Base,
Clinical Investigation Facility

United States

Guillaume
Hoareau, DVM, PhD

Will test the prognostic potential of LPC using an established rate modelof cardiac arrest and human patients

Feinstein Institutefor Medical Reaserch

United States

Junhwan Kim, PhD

Effect of MAP on cerebral perfusion & metabolism after CA in porcine

Oslo University Hospital

NorwayChristina Skare, MD

Improving simulation-based medical education in pediatric resuscitation:
Real-time feedback and visual attention

Medical University of Vienna

United States

Michael Wagner, MD

Test the feasibility and yield of nanopore sequencing, as compared to culture,
for assessment of body fluid speciments from post Cardiac Arrest patients

Univerisity of Pittsburgh

United States

Alexandra Weissman, MD

Soochow University Second
Affiliated Hospital

China

Mechanisms ot pharmacological hypothermia induced by cannabinoid
receptor agonist WIN55, 212-2 on outcomes of CPR(Research at Virginia
Commonwealth University)(United States)

Yan Xiao, MD

TOTAL ($)

$295,019

SUMMARY OF GRANTS (continued)
GRANT TITLE

INSTITUTION

COUNTRY

LEAD RESEARCHER

Test hypothesis that rapidly induced therapeutic hypothermia in those with acute coronary occlusion extends thedoor to perfusion time from 120 to 240 minutes with no increase in myocardial infarct size.

University of Arizona

United States

MadhanShanmugasundaram, MD

Determining the impact of telemedicine on outcomes after pediatric out-of-hospital cardiac arrest

Avera McKenna Hospital

United States

Katie A. DeJong, DO

Role of electrical impedance in pseudo pulseless electrical activity

Dartmouth Hitchcock
Medical Center

United States

Harman S. Gill, MD

The usage and effects of epinephrine in pseudo-PEA

University of Pennsylvania

United States

Felipe Teran-Merino, MD

Impact of kynurenin pathway (KP) inhibition on survival and neurological outcome after cardiac arrest and CPR

Istituto di Ricerche
Farmacologiche Mario NegriItaly

Aurora Magliocca, MD

Define subsets of pulseless electrical activity (PEA) following initial out-of-hospital cardiac rhythm analysis using
machine learning

University of Pennsylvania

United States

Steven Balian, MD

University of Pennsylvania

United States

Marion Leary, MD

Mechanisms of coagulation following OHCA and how influenced by post arrest care including
therapeutic hypothermia.

Yeouido St. Mary’s
Hospital, Seoul

Korea

Testing hypothesis that shock burden will intensify myocardial injury

Rosalind Franklin Universityof Medicine and Science

United States

Salvatore Aiello, MS

Feasiblity of random allocation to active RIC vs. Sham RIC quickly upon ED arrival following resuscitation

University of Washington

United States

Emily Bartlett, MD

Investigate the pharmacokinetics of ART-123 in healthy pigs to verify that the relatively prolonged circulation times
seen in other species will be reproduced in swine.

University of Michigan

United States

Colin Greineder

Determine potential neuroprotective effects of dexmedetomidine

Massachusetts General
Hospital, Simches ResearchCenterUnited States

Michael Silverman, MD

Rapid Cycle Deliberate Practice in First Five Minutes Training to Improve Team Dynamics and Resuscitation Skills

Northeast Ohio MedicalUniversity

United States

Wendy Van Ittersum, MD

Determine whether systemic allogeneic CDC administration reduces myocardial and neurological injury in swine with
post-cardiac arrest syndrome.

University of Buffalo

United States

Brian Weil, PhD

Investigate whether the three second pause in compressions is long enough to provide two ventilations when usingmechanical chest compressions during out-of-hospital cardiac arrest

Amsterdam University
Medical Center

Netherlands

Hans van Schuppen, M.D.

Establish the effectiveness of physiologically guided resuscitation by use of NIRS during CPR

Kyoto University HealthServiceJapan

Takeyuki Kiguchi, M.D.

2018

Advance healthcare provider resuscitation quality using an immersive augmented reality CPR training system

TOTAL ($)

Jung-hee Wee, MD$706,057

2014 – 2016

2017

SUMMARY OF GRANTS (continued)
GRANT TITLE

INSTITUTION

COUNTRY

LEAD RESEARCHER

Investigation of organ dysfunction of diabetics following cardiac arrest

Aarhus University Hospital

DenmarkLauge Vammen, MD

The study of adrenaline and its effects on cardiac arrest

St. Michael’s University

CanadaSteve Lin, MD

Use eye-tracking technology to characterize how providers focus their visual attention during newborn resuscitation
and assess the impact of a novel resuscitation monitor

University of Pennsylvania

United States

Elizabeth E. Foglia, MD

Study involving cardiogenic shock patients randomized to therapeutic hypothermia plus standard medical care or
standard medical care alone

University ofChicago Medicine

United States

Jonathan Paul, MD

Test use of Coenzyme Q10 for neuroprotection in post-cardiac arrest patients to mitigate mitochondrial injury

Aarhus University Hospital

Denmark

Mathias Holmberg, MD

A scoping review of existing studies investigating OHCA in the Arab Gulf Region

Fanshawe CollegeCanada

Alan M. Batt, MICP

Implementation of a multicenter registry for pediatric ED resuscitations using video recording

University of Pennsylvania

United States

Aaron Donoghue, MD

Development of multimodal monitoring and treatment protocols for high-risk post-arrest patients

University of Pittsburgh

United States

Jonathan Elmer, MD

Optimizing public access defibrillation deployment incorporating hours of operation

University of Toronto

CanadaTimothy Chan, PhD

Test hypothesis that therapeutic hypothermia will be anti-arrhythmic during resuscitation and improve ROSC afterVF arrest

Case WesternReserve UniversityUnited StatesJoseph Stephen
Piktel, MD

To investigate temporal differences between asphyxial induced cardiac arrest (ACA) and ventricular fibrillationinduced cardiac arrest (VFCA) and its impact on myocardial and neurological injury; to examine the temporalchanges in brain and cardiac ATP levels, antioxidant reserve, and the generation of reactive oxygen species

Aarhus University Hospital

Denmark

Soren Rahbek, MD

Potassium cardioplegia with calcium reversal for ventricular fibrillation arrest: a blinded randomized controlled trial

University of Pittsburgh

United States

Keith Marrill, MD

TOTAL ($)

$193,525$130,681