2017/9/25

MS Researchers Identify Nerve Pathway That Mediates Gut Dysfunctio­ØãÕ¬Í483Shares

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ResearchersIdentify Nerve
Pathway Linking
Brain
Inflammation, Gut
Dysfunction in MS
AUGUST 23, 2017

BY ALICE MELÃO1

IN NEWS.

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Against My Relapsing MS[Sponsored Post]

Chronic stress and in ammation in the brain can cause multiorgan dysfunction including severe gut failure, mediated by a
newly identi ed nerve pathway in animal models of multiple
sclerosis (MS), a Japanese study shows. 1

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The discovery of this underlying mechanism of MS is
described in the study, “Brain micro-in ammation at speci cvessels dysregulates organ-homeostasis via the activation ofa new neural circuit,” which appeared in the journal eLife.
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https://multiplesclerosisnewstoday.com/2017/08/23/researchers-identify-nerve-pathway-gut-dysfunction-ms/

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2017/9/25

MS Researchers Identify Nerve Pathway That Mediates Gut Dysfunctio

MS is an autoimmune disease caused by CD4+ T-cells thatcross the blood-brain barrier protecting the central nervoussystem. This in ames and stresses the brain and spinal cord.

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In previous studies, a team led by professor Masaaki
Murakami of Japan’s Hokkaido University showed that thesecells could cross the blood-brain barrier in speci c sites.
These entrance sites depend on brain regional activation,
which was found to be triggered by speci c nerve interactions— a mechanism the team called gateway re exes.
In collaboration with other Japanese researchers and a teamfrom Germany, the project aimed to address the potential
correlation among chronic stress, brain in ammation andorgan failures in MS.
Using mice with MS-like disease — the experimental
autoimmune encephalomyelitis model — researchers foundthat animals that had autoreactive CD4+ T-cells and which

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were exposed to stressful conditions developed severe
symptoms such as gastrointestinal failure, or even death.
Detailed analysis of the animals’ brains showed that instressed mice, CD4+ T-cells accumulated in two speci c sites
in the center of the brain around blood vessels. This event
would cause in ammation around those vessels, andactivation of a nerve pathway that is commonly turned off.
This switch led to gut dysfunction, bleeding and failure.
“These results demonstrate a direct link between brain microin ammation and fatal gastrointestinal diseases via theestablishment of a new neural pathway under stress,” 1

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Murakami, the study’s senior author, said in a news release.
Researchers were able to prevent gut symptoms by inhibitingin ammation in the brain or blocking the nerve pathway
responsible for driving the signals from the brain to thegastrointestinal tract.
“Micro-in ammation in the brain is also seen in Alzheimer’s

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disease and Parkinson’s disease,” Murakamai concluded. “Soit’s of particular interest to investigate possible connections
between brain micro-in ammations and organ dysfunctions,
including those within the brain itself, in those patients.”

It’s Time to Speak Up to Guard Your
Healthcare Bene tsTAGGED BRAIN, GUT, INFLAMMATION, NERVE PATHWAY, ORGAN DYSFUNCTION,STRESS, T-CELLS.

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MS Researchers Identify Nerve Pathway That Mediates Gut Dysfunctio

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2 comments
brian hibbs says:

August 28, 2017 at 11:08 AM

The enteric nervous system is the direct link
between the stomach and the brain thus having
access to the CNS.
* We also need to study Spirochaetes and how todestroy them!
Reply

charles says:

Study Links MIF, D-DT Molecules to
Progressive Multiple Sclerosis
Development

August 28, 2017 at 2:01 PM

i think that another conceptual wrinkle may be thedensity of neural tissue in the gut itself. while
multiple sclerosis attacks the central nervous
system (brain, spinal cord, optic nerves), might notother heavily innervated tissues also be at risk? i’mlooking at you, gut.

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