Press Release

September 11, 2017
Keio University

Announcement of The Keio Medical Science Prize 2017
Keio University annually awards The Keio Medical Science Prize to recognize researchers who have made anoutstanding contribution to the fields of medicine or the life sciences. It is the only prize of its kind awarded by aJapanese university, and 7 laureates of this Prize have later won the Nobel Prize. The 22nd Keio Medical Science Prize
is awarded to Prof. John E. Dick and Prof. Seiji Ogawa.

1. LaureatesJohn E. Dick, PhD FRS

Seiji Ogawa, PhD
Canada Research Chairin Stem Cell Biology andSenior Scientist, Princess
Margaret Cancer Centre,
University Health Network ;and Professor,
Department of MolecularGenetics, University ofToronto“Identification ofcancer stem cells”

Research Professor,Kansei Fukushi ResearchCenter, Tohoku Fukushi
University“Development offunctional MRI”

2. Award Ceremony and Events
The award ceremony and commemorative lectures will be held on November 30, 2017 at Keio University School ofMedicine, located on Keio University’s Shinanomachi Campus.

Award Ceremony and Commemorative Lectures
Date & Time: November 30, 2017, 14:00-17:30
Venue:
Kitasato Memorial Hall, Keio University School of Medicine, Shinanomachi Campus, Tokyo, JapanLanguage:
English and JapaneseSimultaneous translation available (English-Japanese/Japanese-English)
Admission: Open to the public

Attachments:(1) The Keio Medical Science Prize(2) The Keio Medical Science Prize Laureate 2017

Inquiries: Secretariat, Keio University Medical Science Fund
TEL: +81-3-5363-3609
URL: http://www.ms-fund.keio.ac.jp/prize/
FAX: +81-3-5363-3215
E-mail: k-msf@adst.keio.ac.jp
Publisher: Office of General Affairs, Keio University School of Medicine
TEL: +81-3-5363-3611
URL: http://www.med.keio.ac.jp/en/
FAX: +81-3-5363-3612
E-mail: med-koho@adst.keio.ac.jp

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Attachment (1)The Keio Medical Science Prize
1. BackgroundIn the fall of 1994, Dr. Mitsunada Sakaguchi, a 1940 alumnus of the School of Medicine, donated five billion yen to Keio
University with the expressed desire that it be used to commend outstanding researchers, to encourage medical researchand its creative progress at Keio through grants, and to promote worldwide medical advances. In keeping with Dr.
Sakaguchi's commitment, Keio launched The Keio University Medical Science Fund on April 1, 1995. Dr. Sakaguchi
made an additional donation of two billion yen in July 1999, bringing the fund to a total of seven billion yen.
2. Initiatives
 The Keio Medical Science Prize Grants for International Activities in Medicine and the Life Sciences Medical School Faculty and Alumni Grants
 Research Grants for Medicine and the Life Sciences Sakaguchi Laboratory
3. Objective
The Keio Medical Science Prize gives recognition to the outstanding and creative achievements of researchers in thefields of medicine and the life sciences, in particular those contributing to scientific developments in medicine. It aims topromote worldwide advances in medicine and the life sciences, encourage the expansion of researcher networksthroughout the world, and contribute to the well-being of humankind.
4. Prize
Laureates receive a certificate of merit, medal, and a monetary award of 10 million yen. The award ceremony andcommemorative lectures are held at Keio University.
5. Nomination and Selection
The Keio Medical Science Prize is an international award, and each year academics and researchers from around theworld are invited to nominate a candidate. Laureates are then selected through a rigorous review process by about ninety
Japanese academics from both within and outside of Keio University.
6. 2016 Prize Laureates
Svante Pääbo
Molecular Elucidation of Human Origin
Tasuku Honjo
Elucidation of molecular mechanism of autophagy
Identification of PD-1 and Establishment of Cancer Immunotherapy Principle by PD-1 Blockade
7. Nobel Prize Winning Laureates
2015
Yoshinori Ohsumi (The Nobel Prize in Physiology or Medicine 2016)
Discoveries of mechanisms for autophagy
2010
Jules A. Hoffmann (The Nobel Prize in Physiology or Medicine 2011)
Discovery of Insect-innate Immune System and Toll Receptors
2006
Thomas A. Steitz (The Nobel Prize in Chemistry 2009)
Structural Basis of Large Ribosomal Subunit Function and Drug Development
2004
Roger Y. Tsien (The Nobel Prize in Chemistry 2008)
Visualization and Control of Molecules within Living Cells
2002
Barry J. Marshall (The Nobel Prize in Physiology or Medicine 2005)
Establishment of Diagnostic Techniques and Treatment for Helicobacter Pylori
1999
Elizabeth Helen Blackburn (The Nobel Prize in Physiology or Medicine 2009)
Telomeres and Telomerase
1996
Stanley B. Prusiner (The Nobel Prize in Physiology or Medicine 1997)
Discovery of Prions and Prion Diseases
2/4Attachment (2a)The Keio Medical Science Prize 2017 Laureate“Identification of cancer stem cells”
John E. Dick, PhD FRSCanada Research Chair in Stem Cell Biology and Senior Scientist, Princess Margaret Cancer Centre, University Health
Network ; and Professor, Department of Molecular Genetics, University of Toronto
Tissue stem cells exhibit the capacity for self-renewal and differentiation into cells of various types. These multipotent
stem cells are the principal source of the cells in adult tissue. The idea that stem cells might also be present in cancer
tissues, i.e., the "cancer stem cell hypothesis," was first proposed long ago, but bona fide cancer stem cells were notisolated for many years. Professor John E. Dick was the first to isolate cells expressing hematopoietic stem cell surface
markers from human leukemia cells, and transplant them into immunocompromised mice. This provided the first evidence
that human leukemia can be maintained in mice, and the first indication that stem cells are present and active in leukemia.
Beginning with these findings, the field of cancer stem cell research has continued to advance and it has since become
clear that cancer stem cells play roles in solid tumors as well. Cancer stem cells are more resistant to therapeuticinterventions than normal cancer cells, and serve as source cells in cancer recurrence and metastasis. Professor Dick 's
contribution is immeasurable, as he gave rise to the idea that cancer stem cells must be destroyed for cancers to beeradicated.
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Registered Radiological Technologist, Misericordia General Hospital
B.Sc. (Hons) Dept. of Microbiology, University of Manitoba
Ph.D. Microbiology and Biochemistry, University of Manitoba
Graduate Student, Dr. J. Wright, Department of Microbiology and Manitoba Institute of Cell
Biology, University of Manitoba, NSERC Scholarship, MHRC Scholarship
Post-doctoral Fellow, Dr. A. Bernstein, Ontario Cancer Institute and Mount Sinai Hospital,Research Institute, University of Toronto MRC Post-doctoral Fellowship
Scientist, Department of Genetics, Research Institute Hospital for Sick Children, Toronto
Assistant Professor, Department of Molecular and Medical Genetics, University of Toronto,
TorontoResearch Scientist of the National Cancer Institute of Canada
Associate Professor, Department of Molecular and Medical Genetics, University of Toronto
Senior Scientist, Department of Genetics, Research Institute, Hospital for Sick Children, Toronto
Professor, Department of Molecular Genetics, University of Toronto, Toronto
Medical Research Council of Canada Scientist
Canada Research Chair in Stem Cell Biology, Senior Scientist, Princess Margaret Cancer Centre,University Health Network, Toronto
Investigator, McEwen Centre for Regenerative Medicine, University Health Network, Toronto
Director, Program in Cancer Stem Cells, Ontario Institute for Cancer Research, (OICR), Toronto
Director, Translational Research Initiative in Leukemia, Ontario Institute for Cancer Research,(OICR), Toronto

Comments from Professor Dick
It is with gratitude that I accept the Keio Medical Science Prize. Science is not done in isolation and I have had
the good fortune to be surrounded by wonderful colleagues in Toronto who set the highest standards for scientificthought that continuously challenged me to tackle biological challenges with rigour and clear thinking. All of ourwork on the biology of normal and leukemic human stem cells was the cumulative effort of many students andpost-docs who contributed so much to the thinking and execution of the experimental findings. I dedicate thisaward to them.

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Attachment (2b)The Keio Medical Science Prize 2017 Laureate“Development of functional MRI”
Seiji Ogawa, PhD
Research Professor, Kansei Fukushi Research Center, Tohoku Fukushi University
Professor Seiji Ogawa developed a technique for detecting MRI (magnetic resonance imaging) signals that depends onblood oxygenation levels in the brain, which he named BOLD (for Blood Oxygen Level Dependent). Professor Ogawa
has shown that BOLD signals can be used in functional mapping of the human brain following sensory stimulation,
establishing the basic principles underlying functional MRI (fMRI). fMRI in turn has paved the way to the mapping of
human brain activity non-invasively and without the use of radioactive isotopes. The ability to measure whole brain
activity, which enables the investigation of distributed patterns of activity as well as functional localization of the brain,
is one of key advantages of fMRI. New applications of fMRI, such as decoding of brain activity and identification of
biomarkers of neuropsychiatric disease, continue to be developed. Professor Ogawa's pioneering work on fMRI is amilestone technology that plays indispensable roles in contemporary neuroscience.
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B.S., Applied Physics University of Tokyo, Tokyo, Japan
PhD in Chemistry, Stanford University, Stanford, California, USA
Research Associate, Radiation Research Laboratories Mellon Institute, Pittsburgh, PA
Postdoctoral Fellow, Stanford University, Stanford, CA
Member of the Technical Staff
Principal Investigator, Biophysics Research
Bell Laboratories, AT&T, Murray Hill, NJ
Distinguished Member of the Technical Staff,
Biophysics Research/Biological Computation Research
Bell Laboratories, AT&T/ Lucent Technologies, Murray Hill, NJ
Visiting Professor, Biophysics/Physiology Department
Albert Einstein College of Medicine, Yeshiva University Bronx, New York
Director, Ogawa Laboratories for Brain Function Research Hamano Life Science
Research Foundation, Tokyo, Japan
Professor (special appointment), Kansei Fukushi Research Center, Tohoku Fukushi University,Sendai, Japan
Visiting Professor, Graduate School of Human Relations, Keio University, Tokyo, Japan
Visiting Professor, Neuroscience Research Institute, Gachon University, Incheon, Korea
Visiting Professor, Biophysics/Physiology Department Albert Einstein College of Medicine,
Yeshiva University, Bronx, New YorkR&D Advisor, National Institute of Information and Communication Technology

Comments from Professor Ogawa
It is a great honor to receive the prestigious Keio Medical Science Prize and to join the ranks of the renowned previous
laureates. The MRI phenomenon I encountered during my fundamental research a quarter of century ago has seen
applications in brain science far beyond my expectations at the time. The successful development of the neuro-imaging
field is the product of efforts by great many talented scientists around the world.

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