The 26th Hot Spring Harbor International Symposium−Trans-Omics: New Approaches in Biology and Medicine−
Medical Institute of Bioregulation, Kyushu University

November 2-3, 2016
Collaborative Research Station Hall I, Hospital Campus, Kyushu University, Fukuoka, JAPAN

Wednesday, November 2, 2016
10:00-10:05 Opening Remarks: Yusaku Nakabeppu (Director of Medical Institute of Bioregulation)

Session 1:

Signaling Networks

Chair: Takeshi Bamba

10:05-10:30 S-01: Mariko Okada (Osaka University, Japan)
Multiple-scale cooperativity in signal-transcription network for cellularcommitment
10:30-10:55 S-02: Hiroyuki Kubota (Kyushu University, Japan)Trans-omic analysis of insulin action-toward in vivo trans-omic analysis10:55-11:30 S-03: Uwe Sauer (ETH Zurich, Switzerland)
Coordination of metabolism through metabolite-protein interactions
11:30-11:40 Group Photos
11:40-13:00 Lunch (Transomics meeting by invitation only)
Session 2:

Transcription, Translation and Robustness Chair: Mikita Suyama

13:00-13:25 S-04: Hisao Moriya (Okayama University, Japan)
Consequences of protein overexpression

13:25-13:50 S-05: Yasuyuki Ohkawa (Kyushu University, Japan)
The baseline of transcription level is determined by selective incorporation ofhistone H3 variants
13:50-14:25 S-06: Timothy J. Stasevich (Colorado State University, USA)
Real-time imaging of single mRNA translation dynamics in living cells
14:25-14:45 Coffee break
Session 3:

Short Talks by Young Scientists

Chair: Tohru Ishitani

14:45-16:45 Short talks of 12 minutes each (see p.4 for details)
16:45-17:05 Coffee break

Session 4:

Development and Differentiation

Chair: Atsushi Suzuki

17:05-17:30 S-07: Hiroyuki Sasaki (Kyushu University, Japan)
Multiple functions of the epigenetic regulator UHRF1 in mouse oocytes
revealed by trans-omics approaches
17:30-17:55 S-08: Akira Nakamura (Kumamoto University, Japan)
Search for new factors that direct germ cell formation in the Drosophila
embryo17:55-18:20 S-9: Naoki Irie (University of Tokyo, Japan)
Why are vertebrates’ organogenesis stages evolutionarily conservative?
19:00-

Dinner party (by invitation only)Thursday, November 3, 2016
Session 5:

Disease_I

Chair: Hiroki Shibata

10:30-10:55 S-10: Tatsuhiko Tsunoda (Tokyo Medical and Dental University, Japan)
Trans-omic analysis strategy for precision medicine
10:55-11:20 S-11: Yoshiyuki Minegishi (Tokushima University, Japan)
Identification of the molecular pathogenesis of hyper-IgE syndrome
11:20-11:55 S-12: Yong Hou (Beijing Genomics Institute, China)
Efforts to push single cell trans-omics for cancer research

11:55-13:30 Lunch
Session 6:

Disease_I I

Chair: Yoshihiro Yamanishi

13:30-13:55 S-13: Keiichi Nakayama (Kyushu University, Japan)
Next-generation proteomics unveils a global landscape ofcancer metabolism
13:55-14:20 S-14: Jun Koseki (Osaka University, Japan)
Trans-omics analysis shows novel functional change in the ornithine
metabolic pathway between cancer stem cells and non-cancer stem cells

14:20-14:55 S-15: Marie Evangelista (Genentech, USA)
Lessons from targeting metabolic dependencies in PDAC
14:55-15:00 Closing Remarks: Hiroyuki Sasaki (Kyushu University, Japan)

Session3: Short-Talk Session for Young Scientists

Chair: Tohru Ishitani

Wednesday, November, 2 2016
14:45-16:45

Short talks of 12 minutes each

Y-01: Shinjiro Hino (Kumamoto University, Japan)
Regulation of cellular metabolism by histone demethylase LSD1
Y-02: Kou Motani (Tokushima University, Japan)
Identification of STING-dependent secreted proteins using quantitative proteomic analysis
Y-03: Kenji Shimazu (Tokushima University, Japan)
Characterization of target genes for inhibitory co-receptor PD-1 by CAGE
Y-04: Yuki Kawasaki (Tokyo Medical and Dental University, Japan)
Development of the novel method “EnIGMA” for simultaneous identification ofmethylcytosine and hydroxymethylcytosine
Y-05: Yuki Akieda (Kyushu University, Japan)
Apoptosis-mediated elimination of "Wnt/β-catenin signaling noise" supports precise
embryonic patterning
Y-06: Yuta Katayama (Kyushu University, Japan)
CHD8 haploinsufficiency results in autistic-like phenotypes in mice
Y-07: Ryusuke Sawada (Kyushu University, Japan)
Transomics-based drug repositioning for a wide range of diseases
Y-08: Kai Inui (Kyushu University, Japan)
Analysis of nonsense-mediated mRNA decay (NMD) using genomic and transcriptomic data
Y-09: Yuuta Imoto (Kyushu University, Japan)
Post-genomic analysis of supramolecular nanomachinery for membrane-bounded organelle
division
Y-10: Yuki Sohma (Kyushu University, Japan)
Metabolomics on designed metabolic dynamics by synthetic genetic circuits