The 16th International Symposium of the Institute Network for Biomedical Sciences
KEY FORUM 2021 International Symposium

The Front Lines of Biomedical Research on the Nervous System
Institute of Molecular Embryology and Genetics, Kumamoto University

November 11-12, 2021
Kumamoto University, Japan

Thursday, November 11, 2021
13:00 - 13:05

Opening Remarks
Hitoshi Niwa (Director of Institute of Molecular Embryology and Genetics,Kumamoto University)

Session 1:

Medical Sciences

Chairs: TBD

13:05-13:25

S-01: Madoka Suzuki (Institute for Protein Research, Osaka University)
Intracellular heat diffusion acting behind thermogenesis

13:25-13:45

S-02: Asako Shindo (Institute of Molecular Embryology and Genetics,Kumamoto University)
Nutritional control of thyroid morphogenesis through gastrointestinal
hormones

13:45-14:05

S-03: Katsumori Segawa ((Medical Research Institute, Tokyo Medical andDental University)
Physiology and pathology of phospholipid flippases in the plasma membrane)

14:05-14:17

O-01: Eiji Hara (Research Institute for Microbial Diseases, OsakaUniversity)
Identification of gut bacteria abundant in CRC patients that promotetumorigenesis

14:17-14:29

O-02: Takahiro Eguchi (The Institute of Medical Science, The Universityof Tokyo)
A study of therapeutic interventions aimed at enhancing neuromuscularjunction innervation and skeletal muscle mass

14:29-14:41

O-03: Tomohiko Okazaki (Institute for Genetic Medicine, HokkaidoUniversity)
Selective regulation of type I interferon and apoptosis and its relevance tobrain protection against viral infection

14:41-14:55

BreakSession 2:

Molecules and Omics

Chairs: TBD

14:55-15:07

O-04: Keita Iida Institute for Protein Research, Osaka University)
Mathematical and semiological approach to single-cell and spatialtranscriptomics
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15:07-15:27

S-04: Shinpei Kawaoka (Institute of Development, Aging and Cancer,
Tohoku University)
Understanding host pathophysiology in cancers using multi-omics andgenetics

15:27-15:39

O-05: Shusaku Abe (Medical Institute of Bioregulation, Kyushu University)
Reprogramming of the histone H3.3 landscape in the early mouse embryo

15:39-15:51

O-06: Kazuhiro Murakami (Cancer Research Institute of Kanazawa
University)
A Genome-Scale CRISPR screen reveals novel factors regulating
Wnt-dependent renewal of mouse gastric epithelial cells

15:51-16:11

S-05: Tomohide Saio (Institute of Advanced Medical Sciences, TokushimaUniversity)
Mechanistic insight into chaperone-mediated protein homeostasis

16:11-16:23

O-07: Tomoaki Koga (Institute of Molecular Embryology and Genetics,Kumamoto University)
Epigenetic regulation of inflammatory myeloid cells

Short-talk Session 1
Chairs: TBD

16:23-16:31

Y-01: Sweksha Lohani (Research Institute for Microbial Diseases, Osaka
University)
PRL-driven apoptosis induction in confluent epithelium regulates epithelial
cell density

16:31-16:39

Y-02: Tatsuya Suzuki (Research Institute for Microbial Diseases, Osaka
University)
Innate Immunity is required for pathogenicity of Flavivirus infection.

16:39-17:00

BreakKEY FORUM part 1
Chairs: TBD

17:00-17:30

K-01: Ki-Jun Yoon (Kaist, Korea)
Deciphering the Neural Epitranscriptome: The Roles of m6A RNA
Modification in Neurodevelopment

17:30-18:00

K-02: Fumio Matsuzaki (BDR, RIKEN)
Generation of the complex brains in mammalian evolution: a developmental
point of view

18:00-18:30

K-03: Pierre Vanderhaegen (Université Libre de Bruxelles)
TBA

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Friday, November 12, 2021
Session 3:

Cellular and Metabolic Topics

Chairs: TBD

9:00-9:20

S-06: Takashi Nishimiura (Institute for Molecular and Cellular Regulation,Gunma University)
Regulation of brain insulin signaling in Drosophila

9:20-9:40

S-07: Takayuki Nojima (Medical Institute of Bioregulation, Kyushu
University)
Mechanism of Co-transcriptional RNA splicing

9:40-10:00

S-08: Eishu Hirata (Cancer Research Institute of Kanazawa University)
Multifaceted interactions between cancer cells and glial cells in brain
metastasis

10:00-10:12

O-08: Hiroki Sekine (Institute of Development, Aging and Cancer, Tohoku
University)
Chronic hypoxia enhances proinflammatory response of macrophages byinhibiting lysosomal activity

10:12-10:24

O-09: Mayumi Yamada (Institute for Frontier Life and Medical Sciences,
Kyoto University)
Analysis of neural stem cell regulatory mechanisms using optogenetics

10:24-10:36

O-10: Yuhkoh Satouh (Institute for Molecular and Cellular Regulation,Gunma University)
Clathrin-mediated endocytosis is essential for the selective degradation ofmaternal membrane proteins and preimplantation development

10:36-10:48

O-11: Masahiro Shimizu (Medical Research Institute, Tokyo Medical andDental University)
WNK regulates Wnt signaling and β-Catenin levels by interfering with theinteraction between β-Catenin and GID

10:48-11:00

Break

Short-talk Session 2
Chairs: TBD

11:00-11:08

Y-03: Zhe Wang (Institute for Frontier Life and Medical Sciences, Kyoto
University)
Hydrogel for precise manipulation of human pluripotent stem cells
microenvironment

11:08-11:16

Y-04: Sheng Jindan (Cancer Research Institute of Kanazawa University)
Treatment of RB1-intact cancers with CDK4/6 inhibitor combination therapy

11:16-11:24

Y-05: Kazufumi Kunimura (Medical Institute of Bioregulation, Kyushu
University)
The molecular basis for IL-31 production and IL-31-mediated itchtransmission: from biology to drug development

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11:24-11:32

Y-06: Shin Fujimaki (Institute of Molecular Embryology and Genetics,Kumamoto University)
Endothelial−muscular axis regulates skeletal muscle mass

11:32-11:40

Y-07: Ryota Inoue (Institute for Molecular and Cellular Regulation, GunmaUniversity)
Uncoupling protein 2 and aldolase B impacts insulin release by modulating
mitochondrial function and store-operated Ca2+ entry in type 2 diabetes

11:40-11:48

Y-08: Ryotaro Tsutsumi (Institute for Protein Research, Osaka University)
Elucidation of the molecular and pathological mechanisms of ciliopathies
using the new model mouse generated by genome editing technology

11:48-13:10

Lunch / Steering Committee Meeting (Members Only)
Group photo shootingShort-talk Session 3
Chairs: TBD

13:10-13:18

Y-09: Nobutaka Numoto (Medical Research Institute, Tokyo Medical andDental University)
Molecular mechanism of lupus-related self-antigen recognition by B cell inhibitory
co-receptor CD72

13:18-13:26

Y-10: Tomohiro Yabushita (The Institute of Medical Science, TheUniversity of Tokyo)
Genome-wide CRISPR activation screen identifies multiple clinicallyactionable resistance mechanisms with DNA-hypomethylating agents inmyeloid malignancies.

13:26-13:34

Y-11: Yingxu Liu (Institute of Development, Aging and Cancer, TohokuUniversity)
Altruistic Social Activity Impacts on Depressive Symptoms and Brain
Regional Gray Matter Volume: Voxel-Based Morphometry Analysis from8695 Old Adults

13:34-13:42

Y-12: Honoka Kawamukai (The Institute of Medical Science, TokushimaUniversity)
PRn inhibits the binding of KapB2 to FUS

13:42-13:50

Y-13: Yuki Tanaka (Institute for Genetic Medicine, Hokkaido University)
Metabolite NTP1 suppresses CNS inflammation via pathogenic T cell activation

13:50-14:05

BreakSession 4:

Technology, SARS CoVChairs: TBD

14:05-14:25

S-09: Toshio Kitamura (The Institute of Medical Science, The University ofTokyo)
Development of a G0 marker and its application in studying stem cell
including cancer stem cells
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S-10: Keizo Tomonaga (Institute for Frontier Life and Medical Sciences,Kyoto University)
A novel intranuclear RNA vector system targeting stem cells and the central
nervous system

14:45-15:05

S-11: Tokiko Watanabe (Research Institute for Microbial Diseases, OsakaUniversity)
A strategy for virus survival: the genetic diversity of SARS-CoV-2

15:05-15:25

S-12: Akinori Takaoka (Institute for Genetic Medicine, HokkaidoUniversity)
Innate sensing mechanism for SARS-CoV-2 infection in human lung cells

15:25-15:37

O-12: Harunori Yoshikawa (Institute of Advanced Medical Sciences,Tokushima University)
Efficient analysis of translation-active ribosomes in cells and tissues

15:37-16:00

Short-talk Awards Ceremony & BreakKEY FORUM part 2Chairs: TBD

16:00-16:30

K-04: Kumi Kuroda (CBS, RIKEN)
Preoptic signaling as a critical node of affiliative social behaviors in mammals

16:30-17:00

K-05: Ryoichiro Kageyama (Institute for Frontier Life and Medical Sciences,
Kyoto University, RIKEN Center for Brain Science)
Dynamic transcriptional control regulates active versus quiescent neural stemcells

17:00-17:30

K-06: Denis Jabaudon (University of Geneve)
TBA

17:30-18:00

K-07: Hideyuki Okano (Keio University)
TBA

18:00-18:05

Closing Remarks(Institute of Molecular Embryology and Genetics, Kumamoto University)

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