Press Release
FOR RELEASE ON
September 20 at 11:00 a.m. EDT
September 21 at 00:00 a.m. JST
September 21

AT 0 a.m. JST

September 16, 2022
Keio University

Announcement of The Keio Medical Science Prize 2022
Keio University, Japan’s oldest private university located in Tokyo, annually awards The Keio Medical SciencePrize to recognize researchers who have made an outstanding contribution to the fields of medicine or the life
sciences. It is the only prize of its kind awarded by a Japanese university, and 8 laureates of this prize have later
won the Nobel Prize. The 27th Keio Medical Science Prize is awarded to Carl H. June, M.D. from the Universityof Pennsylvania Perelman School of Medicine and Yoshihiro Kawaoka, D.V.M., Ph.D. from the National
Center for Global Health and Medicine Research Institute.

1. Laureates
Carl H. June, M.D.

Yoshihiro Kawaoka, D.V.M., Ph.D.
Richard W. Vague Professor
in Immunotherapy
Director, Center for Cellular
Immunotherapies
Director, Parker Institute forCancer Immunotherapy

Director, ResearchCenter for Global Viral
Diseases,National Center forGlobal Health andMedicine ResearchInstitute

University of Pennsylvania
Perelman School ofMedicine

Project Professor, The
Institute of MedicalScience, The Universityof Tokyo“Development of CAR-T Cell Therapy asa Novel Immunotherapeutic Strategy”“Understanding Viral Pathogenicity for
the Control of Pandemic Infectious
Diseases”

2. Award Events
The award ceremony and commemorative lectures are scheduled as below. Media outlets are welcome to attend, and wewould greatly appreciate any coverage you can provide.
Award Ceremony and Commemorative Lectures
Date & Time: Monday, November 28, 2022, 14:00-17:30
Venue:
Kitasato Memorial Hall, Keio University School of Medicine, Shinanomachi Campus, Tokyo, Japan
Admission: Open to the public and streaming online. The number of participants allowed on site will be limited
according to the infection prevention measures.
Language:
English (Simultaneous translation available)
For more information, please visit the Keio Medical Science Prize website:
https://www.ms-fund.keio.ac.jp/en/prize/
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The Keio Medical Science Prize 2022 Laureate“Development of CAR-T Cell Therapy as a Novel Immunotherapeutic Strategy”
Carl H. June, M.D.
Richard W. Vague Professor in Immunotherapy
Director, Center for Cellular Immunotherapies
Director, Parker Institute for Cancer Immunotherapy
University of Pennsylvania Perelman School of Medicine
Dr. Carl June has pioneered the clinical application of CAR-T cell therapy, a new class of personalized immunotherapy
for cancer and infectious diseases. CAR-T cell therapy uses genetically engineered T cells to produce chimeric antigen
receptors (CARs). Dr. June has elucidated the role of the co-stimulatory molecule CD28 in T cell proliferation and, byexpressing the CAR in combination with co-stimulatory molecules, has advanced CAR-T cell therapy to a practical level
for antigen-specific and potent cytotoxic activity. CAR-T cell therapy has demonstrated breakthrough efficacy in thetreatment of refractory acute leukemia, which does not respond to conventional therapies. CAR-T cell therapy has been
approved in many countries worldwide and has become an established treatment method in clinical practice. Dr. June'sachievements in laying the foundation for further development of new therapeutic strategies through the clinicaldevelopment of CAR-T cell therapy make him deserving of the Keio Medical Science Prize 2022.
Education
1975 B.S.(Biology)
United States Naval Academy, Annapolis, Maryland, USA
1979 M.D.(Medicine) Baylor College of Medicine, Houston, Texas
1985 Postdoctoral Fellow (Oncology/Immunology) Fred Hutchinson Cancer Research Center, Washington
Positions
1978-1979
1979-1980
1980-1982
1980-1982
1982-1983
1982-1983
1983-1985
1986-1990
1990-1995
1995-1999
1999-2001
2001-present
2004-present
2015-present
2016-present

Research Fellow, World Health Organization Immunology Research and Training Center,Geneva, Switzerland
Internship: Basic Medicine, National Naval Medical Center, Bethesda, Maryland, USA
Teaching Fellow, Department of Medicine, Uniformed Services, University of the Health Sciences,
Bethesda, Maryland
Residency: Internal Medicine, National Naval Medical Center, Bethesda, Maryland
Instructor, Department of Medicine, Uniformed Services University
Chief Resident: Internal Medicine, National Naval Medical Center, Bethesda, Maryland
Fellow in Oncology, University of Washington and Fred Hutchinson Cancer Research Center,Seattle, Washington
Assistant Professor, Department of Medicine, Uniformed Services
Associate Professor, Department of Medicine, Uniformed Services
Professor, Department of Medicine, Uniformed Services University of the Health Sciences
Professor of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine
Professor of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Professor of Medicine, University of Pennsylvania School of Medicine
Director, Center for Cellular Immunotherapies at the University of Pennsylvania
Director, Parker Institute for Cancer Immunotherapy at the University of Pennsylvania

Major Honors/Awards
2015
Paul Ehrlich and Ludwig Darmstaedter Prize (shared with J. Allison)
2016
Novartis Prize in Immunology (shared with Z. Eshhar and S. Rosenberg)
2017
Karnofsky Prize from the American Society of Clinical Oncology
2020
Lorraine Cross Sanford Health Award
2021
Dan David Prize from Tel Aviv University
Comment from Carl H. June, M.D.
On behalf of my team at the University of Pennsylvania, I am humbled to accept the Keio Medical Science Prize inrecognition of the development of chimeric antigen receptor T cells for cancer therapy. I am grateful that studies ofapplications of this technology beyond cancer -- for chronic infections, organ transplantation and autoimmune diseases - are now underway in clinical trials on a global basis to treat patients in need.
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The Keio Medical Science Prize 2022 Laureate“Understanding Viral Pathogenicity for the Control of Pandemic Infectious Diseases”
Yoshihiro Kawaoka, D.V.M., Ph.D.
Director, Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research InstituteProject Professor, The Institute of Medical Science, The University of Tokyo

Dr. Yoshihiro Kawaoka has developed a revolutionary technology for the artificial synthesis of influenza viruses.
By synthesizing influenza viruses on demand, he succeeded in clarifying their mechanisms of infection andpropagation, as well as the acquisition of high virulence and drug resistance at the molecular and cellular levels.
Furthermore, he has contributed to the development of new vaccines against novel influenza viruses through theartificial synthesis of viruses. He has also made extensive contributions to pandemic control against the newcoronavirus (SARS-CoV2), including evaluation of the pathogenicity of various variants and their reactivity to drugs
and the development of animal models of infection.
Education
1978
B.S., Hokkaido University, Japan (Veterinary Medicine)
1978
D.V.M., The Ministry of Agriculture and Fishery, Japan
1980
M.S., Hokkaido University, Japan (Microbiology)
1983
Ph.D., Hokkaido University, Japan (Microbiology)
Professional Appointments
1980-1983
Research Associate, Department of Veterinary Microbiology, Faculty of Agriculture, Tottori
University, Japan
1983-1996
Postdoctoral Fellow, St. Jude Children's Research Hospital, Tennessee, USA
1996-1997
Member, St. Jude Children's Research Hospital, Tennessee, USA
1997-present Professor, School of Veterinary Medicine, University of Wisconsin-Madison, Wisconsin, USA
1999-2005
Professor, Department of Microbiology and Immunology, The Institute of Medical Science, TheUniversity of Tokyo, Japan
2005-2021
Director, International Research Center for Infectious Diseases, The Institute of Medical Science, The
University of Tokyo, Japan2021-present Project Professor, The Institute of Medical Science, The University of Tokyo
2021-present Director, Research Center for Global Viral Diseases, National Center for Global Health and Medicine
Research Institute
Major Honors/Awards
2006
Robert Koch Prize (with Peter Palese)
2011
Medal with Purple Ribbon
2013
Member of the United States National Academy of Sciences
2015
Carlos J. Finlay Prize for Microbiology2016
Japan Academy Prize
Comment from Yoshihiro Kawaoka, D.V.M., Ph.D.
It is my honor to receive the Keio Medical Science Prize and follow in the footsteps of previous awardees whose worldclass work I have admired. My selection for this award is humbling, and only made possible thanks to the relentless effortsof past and present members of my laboratories and my collaborators. I am also indebted to the funding agencies and theirofficers, the personnel at the business offices of my institutions, and my colleagues for their constant support. The COVID
pandemic has, and continues to have, devastating effects on public health and economies globally. It is a stark reminderthat infectious diseases will always be a threat. I hope to make a lasting contribution to society by working to reduce theburden caused by infectious diseases.
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The Keio Medical Science Prize
1. BackgroundIn the fall of 1994, Dr. Mitsunada Sakaguchi, a 1940 alumnus of the School of Medicine, donated five billion yen toKeio University with the expressed desire that it be used to commend outstanding researchers, to encourage medical
research and its creative progress at Keio through grants, and to promote worldwide medical advances. In keepingwith Dr. Sakaguchi's commitment, Keio launched The Keio University Medical Science Fund on April 1, 1995. Dr.
Sakaguchi made an additional donation of two billion yen in July 1999, bringing the fund to a total of seven billion
yen.
2. Initiatives⚫ The Keio Medical Science Prize⚫ Grants for International Activities in Medicine and the Life Sciences⚫ Keio Medical Science Rising Star Award⚫ Research Grants for Medicine and the Life Sciences⚫ Sakaguchi Laboratory
3. Objective
The Keio Medical Science Prize gives recognition to the outstanding and creative achievements of researchers in thefields of medicine and the life sciences, in particular those contributing to scientific developments in medicine. It
aims to promote worldwide advances in medicine and the life sciences, encourage the expansion of researcher
networks throughout the world, and contribute to the well-being of humankind.
4. Prize
Laureates receive a certificate of merit, medal, and a monetary award of 10 million yen. The award events and thecommemorative lectures are held at Keio University.
5. Nomination and Selection
The Keio Medical Science Prize is an international award, and each year academics and researchers from around theworld are invited to nominate a candidate. Laureates are then selected through a rigorous review process by aboutninety Japanese academics from both within and outside of Keio University.
Selection Committee 2022
Haruhiko Siomi:
Chairperson of the Committee
Professor, Department of Molecular Biology, Keio University School of Medicine
Shizuo Akira:Specially Appointed Professor, Immunology Frontier Research Center, Osaka University
Masayuki Amagai:
Vice-President, Keio University
Professor, Department of Dermatology, Keio University School of Medicine
Makoto Arita:
Professor, Division of Physiological Chemistry and Metabolism, Keio University Faculty ofPharmacy
Kenya Honda:
Professor, Department of Microbiology and Immunology, Keio University School ofMedicine
Yoshiaki Kubota:
Professor, Department of Anatomy, Keio University School of Medicine
Ryozo Nagai:
President, Jichi Medical University
Jin Nakahara:
Professor, Department of Internal Medicine (Neurology), Keio University School ofMedicine
Tetsuo Noda:
Representative Director, Executive Director, and Institute Director, Japanese Foundation forCancer Research
Takao Shimizu:
Representative Director, Microbial Chemistry Research Foundation
Director, Institute of Microbial Chemistry
Project Leader, National Center for Global Health and Medicine
Yoshiko Takahashi: Professor, Graduate School of Science, Kyoto University
Keiji Tanaka:
Board Chairperson, Tokyo Metropolitan Institute of Medical Science
Masashi Yanagisawa: Director, International Institute for Integrative Sleep Medicine (WPI-IIIS), University ofTsukuba

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6. Nobel Prize Winners from the Keio Medical Science Prize Laureates
1996
Stanley B. Prusiner (The Nobel Prize in Physiology or Medicine 1997)
Discovery of Prions and Prion Diseases
1999
Elizabeth Helen Blackburn (The Nobel Prize in Physiology or Medicine 2009)
Telomeres and Telomerase
2002
Barry J. Marshall (The Nobel Prize in Physiology or Medicine 2005)
Establishment of Diagnostic Techniques and Treatment for Helicobacter Pylori
2004
Roger Y. Tsien (The Nobel Prize in Chemistry 2008)
Visualization and Control of Molecules within Living Cells
2006
Thomas A. Steitz (The Nobel Prize in Chemistry 2009)
Structural Basis of Large Ribosomal Subunit Function and Drug Development
2010
Jules A. Hoffmann (The Nobel Prize in Physiology or Medicine 2011)
Discovery of Insect-innate Immune System and Toll Receptors
2015
Yoshinori Ohsumi (The Nobel Prize in Physiology or Medicine 2016)
Discoveries of Mechanisms for Autophagy
2016
Tasuku Honjo (The Nobel Prize in Physiology or Medicine 2018)
Identification of PD-1 and Establishment of Cancer Immunotherapy Principle by PD-1 Blockade
Contact:
Office of the Keio University Medical Science Fund
TEL: +81-3-5363-3609 FAX: +81-3-5363-3215 k-msf@adst.keio.ac.jp https://www.ms-fund.keio.ac.jp/en/prize/
Publisher:
Office of General Affairs, Keio University School of Medicine
TEL: +81-3-5363-3611 FAX: +81-3-5363-3612 med-koho@adst.keio.ac.jp https://www.med.keio.ac.jp/en/

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