The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine and the 28th
Hot Spring Harbor Symposium

Biomedical Sciences in the Era of Big Data
Medical Institute of Bioregulation, Kyushu University

October 18 - 19, 2018

Main Hall, Centennial Hall Kyushu University School of Medicine
in the Hospital Campus of Kyushu University, Fukuoka

Thursday, October 18, 201809:30 - 09:35

Opening Remarks:
Yusaku Nakabeppu (Director of Medical Institute of Bioregulation, Kyushu
University)

Session 1:

Epigenetics

Chairs:Mitsuyoshi Nakao (Institute of Molecular Embryology and Genetics, Kumamoto University)
Hiroyuki Sasaki (Medical Institute of Bioregulation, Kyushu University)

09:35-10:00

S-01: Toyomasa Katagiri (Institute of Advanced Medical Sciences, Tokushima
University)
Comprehensive molecular features of triple negative breast cancers

10:00-10:15

Y-01: Norifumi Shioda (Institute of Molecular Embryology and Genetics,Kumamoto University)
G-quadruplexes as a therapeutic target for ATR-X syndrome

10:15-10:40

S-02: Takeshi Inagaki (Institute for Molecular and Cellular Regulation, GunmaUniversity)
Epigenetic regulation of adipocyte function

10:40-10:55

Y-02: Sumiyo Morita (Institute for Molecular and Cellular Regulation, GunmaUniversity)
Epigenome editing: Manipulating DNA methylation of specific DNA loci using
CRISPR/Cas9 and a repeating peptide array- based amplification.

10:55-11:10

Y-03: Kazumitsu Maehara (Medical Institute of Bioregulation, Kyushu
University)
Low-input Epigenomic Profiling Technology Toward the Identification ofMyogenic Chromatin Structure

11:10-11:25

Coffee break1

Special Lecture 1
Chair:

Yasuyuki Ohkawa (Medical Institute of Bioregulation, Kyushu University)

11:25-12:05

Suhas Rao (Stanford University, USA)
Cohesin Loss Eliminates All Loop Domains

12:05-12:15

Photo Session

12:15-13:15

Lunch / Steering Committee Meeting of Institute Network for Biomedical Sciences(members only)

13:15-14:15

Poster Session-1

Session 2:

Cancer and immune system

Chairs:Sho Yamasaki (Research Institute for Microbial Diseases, Osaka University)
Yoshihiro Baba (Medical Institute of Bioregulation, Kyushu University)

14:15-14:40

S-03: Toru Kondo (Institute for Genetic Medicine, Hokkaido University)
A novel tumor suppressor Ecrg4 acts as an immunosurveillance factor

14:40-15:05

S-04: Seiya Imoto (Institute of Medical Science, The University of Tokyo)
Immuno-genomic pancancer landscape reveals diverse immune escape mechanisms
and immuno-editing histories

15:05-15:30

S-05: Shumpei Ishikawa (Medical Research Institute, Tokyo Medical and DentalUniversity)
Genomic and Immunogenomics of Diffuse-type Gastric Carcinoma

15:30-15:45

Coffee breakSpecial Lecture 2
Chair:

Mikita Suyama (Medical Institute of Bioregulation, Kyushu University)

15:45-16:25

Peer Bork (European Molecular Biology Laboratory, Germany)
Systemic analysis of the human gut microbiome and beyond2

Session 3:
Chairs:

Structure and drug discover

Toshifumi Takao (Institute for Protein Research, Osaka University)
Daisuke Kohda (Medical Institute of Bioregulation, Kyushu University)

16:25-16:50

S-06: Daron M. Standley (Research Institute for Microbial Diseases, OsakaUniversity)
High-throughput modeling of lymphocyte receptors and their antigens

16:50-17:05

Y-04: Yusuke Kato (Institute of Advanced Medical Sciences, Tokushima
University)
Combined approach of computation and enzymology to investigate novel D-aminoacid oxidase inhibitors

17:05-17:20

Y-05: Toshiki Takei (Institute for Protein Research, Osaka University)
Development and Application of One-Pot Four-Segment Ligation Method Using
Selenoester: Chemical synthesis of Superoxide Dismutase

17:20-18:20

Poster Session-218:20-18:30

Break

18:30-20:30

Mixer3

Friday, October 19, 2018
Session 4:Chairs:

Germ cells and stem cells

Tatsuya Takemoto (Institute of Advanced Medical Sciences, Tokushima University)
Atsushi Suzuki (Medical Institute of Bioregulation, Kyushu University)

09:00-09:25

S-07: Kei-ichiro Ishiguro (Institute of Molecular Embryology and Genetics,Kumamoto University)
A novel germ cell-specific factor, MEIOSIN, recruits STRA8 to direct initiation ofmeiosis in mammals

09:25-09:40

Y-06: Yohei Hayashi (Institute of Development, Aging and Cancer, TohokuUniversity)
Biological significance of metabolic shift in mouse germline differentiation

09:40-10:05

S-08: Chiaki Takahashi (Cancer Research Institute, Kanazawa University)
RB controls undifferentiated status through positive regulation of phosphoglyceratemutases

10:05-10:30

S-09: Junya Toguchida (Institute for Frontier Life and Medical Sciences, Kyoto
University)
Application of iPS cells for disease modeling and drug discovery

10:30-10:45

Coffee breakSpecial Lecture 3
Chair:

Yusaku Nakabeppu (Medical Institute of Bioregulation, Kyushu University)

10:45-11:25

Rachel Rosenthal (University College London, UK)
Cancer evolution and immune escape: TRACERx

Session 5:

Cell biology

Chairs:Ken Sato (Institute for Molecular and Cellular Regulation, Gunma University)
Keiichi Nakayama (Medical Institute of Bioregulation, Kyushu University)

11:25-11:40

Y-07: Tomohiro Yamazaki (Institute for Genetic Medicine, Hokkaido University)
Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly
through phase separation

11:40-12:05

S-10: Takahisa Furukawa (Institute for Protein Research, Osaka University)
Molecular control of light-dark adaptation in retinal photoreceptor cells

412:05-12:20

Y-08: Kohsuke Tsuchiya (Cancer Research Institute, Kanazawa University)
Caspase-1 can initiate two different forms of cell death, pyroptosis and apoptosis,depending on the signaling context

12:20-13:20

Lunch / Steering Committee Meeting of Inter-University Research Network forTrans-Omics Medicine (members only)

Session 6:

Immunology

Chairs:Koichi Ikuta (Institute for Frontier Life and Medical Sciences, Kyoto University)
Yoshinori Fukui (Medical Institute of Bioregulation, Kyushu University)

13:20-13:45

S-11: Kouetsu Ogasawara (Institute of Development, Aging and Cancer, Tohoku
University)
Identification of pathogenic T cells in metal allergy

13:45-14:00

Y-09: Fumiji Saito (Research Institute for Microbial Diseases, Osaka University)
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

14:00-14:15

Y-10: Jun-ichirou Yasunaga (Institute for Frontier Life and Medical Sciences,Kyoto University)
Molecular mechanisms of oncogenesis by human T-cell leukemia virus type1

14:15-14:30

Coffee break

Session7:

Cancer and Genetic disorders

Chairs:Kozo Tanaka (Institute of Development, Aging and Cancer, Tohoku University)
Hiroyuki Kubota (Medical Institute of Bioregulation, Kyushu University)

14:30-14:55

S-12: Mikita Suyama (Medical Institute of Bioregulation, Kyushu University)
Understanding gene regulation using chromosome conformation and epigenomic
data

14:55-15:10

Y-11: Fuyuki Miya (Medical Research Institute, Tokyo Medical and DentalUniversity)
Beyond the limitations of exome analysis for genetic disorders

15:10-15:25

Y-12: Kiyoshi Yamaguchi (Institute of Medical Science, The University of Tokyo)
Molecular features of colorectal cancer in patient with polymerase
proofreading-associated polyposis

515:25-15:40

Early Career Investigator Award Ceremony

15:40-15:45

Closing Remarks:
Mikita Suyama (Medical Institute of Bioregulation, Kyushu University)

6

Poster Presentation
Category 1: Cancer
P-1

Analysis of calcium wave in epithelial homeostasis
Yasuto Takeuchi (Institute for Genetic Medicine, Hokkaido University)

P-2

NRF2-NOTCH3 Axis Promotes Stem-like Phenotype of KEAP1-mutant Non-small Cell Lung Cancers
Keito Okazaki (Institute of Development, Aging and Cancer, Tohoku University)

P-3

Role for efficient chromosome alignment in equal chromosome segregation
Kinue Kuniyasu (Institute of Development, Aging and Cancer, Tohoku University)

P-4

Residual circulating tumor DNA status in relapse prediction post allogeneic hematopoietic stem celltransplantation
Sousuke Nakamura (Institute of Medical Science, The University of Tokyo)

P-5

Sulfated-glycosaminoglycans as Major Humoral Tumor-antigens Identified by Immunogenetic
Repertoire Profiling for Gastric Cancers
Hiroto Katoh (Medical Research Institute, Tokyo Medical and Dental University)

P-6

The role of transcription factor Gli1 in maintaining invasive phenotype of melanoma
I- Ketut Gunarta (Cancer Research Institute, Kanazawa University)

P-7

Involvement of aberrant GSK3β in tumor-promoting autophagy in colorectal cancer
Takahiro Domoto (Cancer Research Institute, Kanazawa University)

P-8

Active B cell division on plasma cell niche is required for lymphoma development
Tomoharu Yasuda (Medical Institute of Bioregulation, Kyushu University)

P-9

Application of Pluripotent Stem Cells for In Vitro Sarcomagenesis
Sakura Tamaki (Institute for Frontier Life and Medical Sciences, Kyoto University)

P-10

Pan-cancer analysis of intratumor heterogeneity associated with patient prognosis using multidimensional
measures
Chie Kikutake (Medical Institute of Bioregulation, Kyushu University)

Category 2: Molecular mechanisms and techniques
P-11

Alternative autophagy pathways conserved from yeast to mammals
Satoko Arakawa (Medical Research Institute, Tokyo Medical and Dental University)

P-12

Neuronal SIRT1 regulates simple sugar selection through FGF21 and oxytocin signalling in mice
Sho Matsui (Institute for Molecular and Cellular Regulation, Gunma University)

P-13

Synthetic Study of D-Ferredoxin-1
Yusuke Ishida (Institute for Protein Research, Osaka University)

P-14

Development of an analytical system for single-cell metabolomics based on high-sensitive
nano-LC/MS/MS
Kohta Nakatani (Medical Institute of Bioregulation, Kyushu University)

7

P-15

Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
Yuhkoh Satouh (Research Institute for Microbial Diseases, Osaka University)

P-16

TRANSOMICS: Integrated Analysis Through Multiple Molecular Layers
Fumiko Matsuzaki (Medical Institute of Bioregulation, Kyushu University)

P-17

Omics approaches in peroxisome biogenesis and human disorders
Kanji Okumoto (Medical Institute of Bioregulation, Kyushu University)

P-18

Integrative approach combining electron microscopy and high-speed AFM revealed the dynamic
conformational exchange of the oligosaccharyltransferase in lipid bilayers
Yuki Kawasaki (Medical Institute of Bioregulation, Kyushu University)

Category 3: Inflammation
P-19

Skeletal abnormalities in mice with constitutively activated MDA5
Nobumasa Soda (Institute for Frontier Life and Medical Sciences, Kyoto University)

P-20

A novel mechanism for induction of tissue-specific immune evasion
Tetsuya Sakurai (Medical Institute of Bioregulation, Kyushu University)

Category 4: Development and stem sell
P-21

The effect of maternal diet and nutritional status on mammalian sex determination
Shingo Miyawaki (Institute of Advanced Medical Sciences, Tokushima University)

P-22

Expansion of human iPS-derived nephron progenitors and modeling nephrotic disease
Shunsuke Tanigawa (Institute of Molecular Embryology and Genetics, Kumamoto University)

P-23

Identification of transcription factors repressing direct conversion of mouse embryonic fibroblasts into
induced hepatocyte-like cells
Masayoshi Yorino (Medical Institute of Bioregulation, Kyushu University)

P-24

Mammalian Dmrt factors orchestrate cerebral cortical development via regional control of neuralprogenitor identity
Dai-jiro Konno (Medical Institute of Bioregulation, Kyushu University)

Category 5: Genome science
P-25

Accurate and Robust Base-calling for Nanopore Raw Reads with Variation of Species Exploiting Neural
Machine Translation Model
Hiroki Konishi (Institute of Medical Science, The University of Tokyo)

P-26

Elucidation of roles of the linear form of chromosomes in eukaryotes
Ami Takeuchi (Institute for Protein Research, Osaka University)P-27

Ddhd1 knockout mice as a model system of hereditary spastic paraplegia
Takuya Morikawa (Medical Institute of Bioregulation, Kyushu University)

8

P-28

HLA controls clinical conversion of Hashimoto Thyroiditis to Graves Disease
Xin Tun (Medical Institute of Bioregulation, Kyushu University)

Category 6: Degenerative disorders
P-29

Impact of HPGCD administration into the cerebral ventricle for Niemann-Pick disease type C
Minami Soga (Institute of Molecular Embryology and Genetics, Kumamoto University)

P-30

G-quadruplexes as a therapeutic target for ATR-X syndrome
Norifumi Shioda (Institute of Molecular Embryology and Genetics, Kumamoto University)

P-31

ICF syndrome proteins CDCA7 and HELLS promote non-homologous end joining
Motoko Unoki (Medical Institute of Bioregulation, Kyushu University)

Category 7: Others
P-32

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptor
Fumiji Saito (Research Institute for Microbial Diseases, Osaka University)

P-33

Overproduction of ATP and Reactive Oxygen Species in Mitochondria by Excessive Magnesium
Osamu Hashizume (Research Institute for Microbial Diseases, Osaka University)

P-34

Molecular mechanisms of oncogenesis by human T-cell leukemia virus type 1
Jun-ichirou Yasunaga (Institute for Frontier Life and Medical Sciences, Kyoto University)

P-35

Molecular features of colorectal cancer in patient with polymerase proofreading-associated polyposis
Kiyoshi Yamaguchi (Institute of Medical Science, The University of Tokyo)

P-36

Epigenome editing: Manipulating DNA methylation of specific DNA loci using CRISPR/Cas9 and a
repeating peptide array-based amplification
Sumiyo Morita (Institute for Molecular and Cellular Regulation, Gunma University)

P-37

Beyond the limitations of exome analysis for genetic disordersFuyuki Miya (Medical Research Institute, Tokyo Medical and Dental University)

P-38

Low-input Epigenomic Profiling Technology Toward the Identification of Myogenic Chromatin Structure
Kazumitsu Maehara (Medical Institute of Bioregulation, Kyushu University)

P-39

Caspase-1 can initiate two different forms of cell death, pyroptosis and apoptosis, depending on thesignaling context
Kohsuke Tsuchiya (Cancer Research Institute, Kanazawa University)

P-40

Neural stem cell-specific Itpa knockout mouse as a model of human epileptic encephalopathy caused byITPA deficiency
Daisuke Tsuchimoto (Medical Institute of Bioregulation, Kyushu University)

P-41

Oligodendrocyte dysfunction due to Chd8 mutation shapes the core autistic phenotypes in mice
Atsuki Kawamura (Medical Institute of Bioregulation, Kyushu University)

P-42

Biological significance of metabolic shift in mouse germline differentiation
Yohei Hayashi (Institute of Development, Aging and Cancer, Tohoku University)9P-43Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phaseseparation
Tomohiro Yamazaki (Institute for Genetic Medicine, Hokkaido University)

P-44

Combined approach of computation and enzymology to investigate novel D-amino acid oxidaseinhibitors
Yusuke Kato (Institute of Advanced Medical Sciences, Tokushima University)

P-45

Development and Application of One-Pot Four-Segment Ligation Method Using Selenoester: ChemicalSynthesis of Superoxide Dismutase
Toshiki Takei (Institute for Protein Research, Osaka University)

10