The 27th Hot Spring Harbor International Symposium

Frontiers in Stem Cell Research and Reprogramming
Medical Institute of Bioregulation, Kyushu University

October 31 - November 1, 2017
Collaborative Research Station-I, Hospital Campus, Kyushu University, Fukuoka, JAPANTuesday, October 31, 2017
10:00 - 10:05

Opening Remarks:
Yusaku Nakabeppu (Director of Medical Institute of Bioregulation)

Session 1:

Pluripotent stem cell and differentiation
Chair: Hiroyuki Sasaki

10:05-10:40

S-01 : Ludovic Vallier (University of Cambridge, UK)
Modeling Metabolic disorders using human Pluripotent Stem Cells

10:40-11:05

S-02 : Takanori Takebe (Yokohama City University, Japan)
Organoid Models of Human Liver Development towards Therapy

11:05-11:30

S-03 : Katsuhiko Hayashi (Kyushu University, Japan)
Stem cell-based in vitro gametogenesis for a better understanding of oocyte
differentiation

11:30-11:40

Group Photos

11:40-13:00

Lunch (meeting invited speakers only)

Session 2:

Stem cell and development
Chair: Yoshihiro Baba

13:00-13:35

S-04 : Frédéric Lemaigre (Université catholique de Louvain, Belgium)
Dynamics of gene regulatory networks in hepatocyte differentiation

13:35-14:00

S-05 : Tomoya Kitajima (RIKEN CDB, Japan)
Roles of large cytoplasmic size of eggs

14:00-14:25

S-06 : Satoshi Yamazaki (University of Tokyo, Japan)
Understanding of bone marrow environment and control of hematopoietic
stem cells

14:25-14:45

Coffee break1

Session 3:

Short Talks by Young Scientists
Chair: Hiroki Shibata

14:45-16:35
16:35-16:55

Short talks of 11 minutes each (see p.3 for details)
Coffee break

Session 4:

Direct reprogramming
Chair: Takeshi Bamba

16:55-17:30

S-07 : Marius Wernig (Stanford University School of Medicine, USA)How to make a neuron17:30-17:55

S-08 : Masaki Ieda (Keio University, Japan)
Direct Cardiac Reprogramming, Cell Fate Decision, and Heart Regeneration

17:55-18:20

S-09 : Atsushi Suzuki (Kyushu University, Japan)
Direct reprogramming to hepatic and intestinal lineages

19:30-

Dinner party (by invitation only)

Wednesday, November 1, 2017
Session 5:

Stem cell and disease
Chair: Keiichi Nakayama

10:00-10:35

S-10 : Nick Barker (A*STAR Institute of Medical Biology, Singapore)Lgr5+ Stem Cells in Epithelial Homeostasis, Regeneration and Cancer

10:35-11:00

S-11 : Tomoyuki Yamaguchi (University of Tokyo, Japan)
Interspecies organogenesis generates autologous functional islets

11:00-11:25

S-12 : Seiji Okada (Kyushu University, Japan)
Spinal cord regeneration and astrogliosis

11:25-13:30

Lunch (meeting invited speakers only)

Session 6:

Stem cell aging and technology
Chair: Yasuyuki Ohkawa

13:30-14:05

S-13 : Han Li (Institut Pasteur, France)
Cellular senescence promotes cellular plasticity in muscle reprogramming
and regeneration

14:05-14:30

S-14 : Keiyo Takubo (National Center for Global Health and Medicine,Japan)
Metabolic regulation and hematopoietic stem cell aging

14:30-14:55

S-15 : Yusuke Torisawa (Kyoto University, Japan)
Cell-generated niches for organ-on-a-chip microdevices

14:55-15:00

Closing Remarks: Atsushi Suzuki (Kyushu University, Japan)
2

Session 3:

Short Talks by Young Scientists
Chair: Hiroki Shibata

Tuesday, October 31, 201714:45-16:45 Short talks of 11 minutes each
Y-01: Kosuke Aoki (Kyushu University, Japan)
Genetic analysis of rippling muscle disease (RMD) using Linkage-Assisted Exome
Sequencing
Y-02: Naoki Haruyama (Kyushu University, Japan)
Accumulation of 8-oxoguanine in the nuclei of newly-generated GABAergic neurons in thenucleus accumbens and islands of Calleja contributes to locomotor hyperactivity in aged mice
Y-03: Kentaro Hosokawa (Kyushu University, Japan)
Foxp2 is essential for the quiescent state and self-renewal capacity of hematopoietic stemcells
Y-04: Takashi Ishiuchi (Kyushu University, Japan)
Epigenetic barrier screen identifies a regulator for extraembryonic development
Y-05: Tetsuro Komatsu (Kyushu University, Japan)
Novel histone H3.3 sub-variants are required for skeletal muscle regeneration
Y-06: Naoto Kubota (Kyushu University, Japan)
Identification of DMRT3 gene enhancer involved in the pathogenesis of spastic cerebral palsy
Y-07: Taito Matsuda (Kyushu University, Japan)
Pioneer factor NeuroD1 rearranges transcriptional and epigenetic architecture in microglia to
execute neuronal reprogramming
Y-08: Akinobu Matsumoto (Kyushu University, Japan)
Functional polypeptides encoded by putative long non-coding RNAs
Y-09: Yuki Soma (Kyushu University, Japan)
Reprogramming of Collective Microbial Cell Behavior
Y-10: Jumpei Yamamoto (Kyushu University, Japan)
Hepatic maturation of iHep cells in cell aggregation culture3