日本レチノイド研究会第２０回学術集会

レチノイド研究の潮流と展望
Perspectives on retinoid research

目崎喜弘、吉川究、三浦光隆、今井克幸、山口典子、妹尾春樹
Yoshihiro Mezaki, Kiwamu Yoshikawa, Mitsutaka Miura, Katsuyuki Imai, Noriko Yamaguchi, and Haruki Senoo

秋田大学大学院・医学系研究科・細胞生物学
Department of Cell Biology and Morphology, Akita University Graduate School of Medicine.

Declining number of papers on retinoids in the 21st century
Papers on retinoids in PubMed
number of papers (left)
number of papers / total number of papers (right, %)
10000
9000
8000
7000
6000
5000
4000
3000
2000
1000
00.4
0.35
0.3
0.25
0.20.150.1
0.05
0Number of papers on retinoids is declining in the 21st century.

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

3000

2000

1000

0Papers on retinoids from 1960 to pesent (2009).

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

3000

2000

RBP(1968)

1000

0Retinol-binding protein (RBP, also called RBP4) was purified on 1968
(Kanai et al. J. Clin. Invest. 1968, 47:2025-2044).

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

CRBP(1978)

3000

2000

RBP(1968)

1000

0

Cellular retinol-binding protein (CRBP, also called RBP1) was purified on 1978
(Ong and Chytil J. Biol. Chem. 1978, 253:828-832).

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

CRBP(1978)

3000

2000

RBP(1968)

1000

0

Number of papers concerning RBP and CRBP is increased
after the discovery of these proteins.

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

CRABP(1978)
CRBP(1978)

3000

2000

RBP(1968)

1000

0

Cellular retinoic acid-binding protein (CRABP) was purified on 1978
(Ong and Chytil J. Biol. Chem. 1978, 253:4551-4554).

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

3000

2000

CRABP(1978)
CRBP(1978) RAR(1987)
RBP(1968)

10000Retinoic acid receptor (RAR) was cloned on 1987
(Petkovich et al. Nature 1987, 330:444-450).

Hallmark discoveries on retinoid research
8000"Retinoids"[Mesh]
7000

6000

"Retinol-Binding Proteins"[Mesh]"Receptors, Retinoic Acid"[Mesh]

5000

4000

3000

2000

CRABP(1978)
CRBP(1978) RAR(1987)
RBP(1968)

1000

0

Number of papers concerning CRABP and RAR is increased rapidly
after the discovery of these proteins.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and neoplasm is shown here.
A vertical line in the column 1985:1989 indicates the year of cloning of RAR.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and “growth and development” is shown here.
There are two peaks around 1970s and 1990s.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and immune system is shown here.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000500

0

Number of papers concerning both retinoids and eye is not affected by the cloning of RAR,
because retinal, not retinoic acid, is involved in the vision as a component of rhodopsin.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and skin is shown here.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and “metabolic diseases” is shown here.
The relationship between RBP and insulin resistance is reported recently.

Fields on retinoid research
2500"Retinoids"[Mesh] AND "Neoplasms"[Mesh]"Retinoids"[Mesh] AND "Growth and Development"[Mesh]"Retinoids"[Mesh] AND "immune system"[Mesh]
2000"Retinoids"[Mesh] AND "Eye"[Mesh]"Retinoids"[Mesh] AND "Skin"[Mesh]"Retinoids"[Mesh] AND "Metabolic Diseases"[Mesh]

1500"Retinoids"[Mesh] AND "chemistry"[Subheading]

1000

500

0

Number of papers concerning both retinoids and chemistry is increased
from the very beginning of the retinoid research.

Summary

Retinoid research has evolved by several breakthroughdiscoveries which occurred every ten years.
A new breakthrough discovery may be needed to furtherdevelop the field of retinoid research.
Variety of specialty and interest in the field of retinoid
research will help develop the field.