A whole newperspective
on ultrasound.

Vega® automated, hands-free, high-throughput ultrasound system

Vega® automated, hands-free, high-throughput ultrasound system• Introduction• Hands-free ultrasound• Widefield imaging

The world’s first hands-free,preclinical automated high-throughput
ultrasound system.

• High throughput• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions

Designed with researchers in mind, our Vega® hands-freeultrasound system is the next generation of preclinicalultrasound imaging. It incorporates an innovative approach toultrasound that produces high-resolution 2D and 3D images ofmultiple mice in just minutes.
This powerful ultrasound system gives you:• Easy-to-use, hands-free transducers• Support• High-speed, high-throughput performance• Contact us• Widefield imaging• Multiple modes for multiple applications• Flexible visualization and analysis software• Small benchtop footprint

2 |Vega® automated, hands-free, high-throughput ultrasound system

Ultrasound without a sonographer.
• Introduction• Hands-free ultrasound• Widefield imaging• High throughput• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

A hands-free system delivers more consistent results because it removes the need for a handheld transducer. Unlike traditional
ultrasound systems, the Vega system uses a bottom-up approach with the transducers located under the imaging stage.
The automated positioning of the transducer enables you to scan across the whole body, producing high-resolution 3D data thatlooks more like MRI images than traditional ultrasound.

Vega hands-free ultrasound—fast, easy, reproducible• Easy to use – Requires a minimal amount of training, withno dedicated sonographer required. Just place mice on theimaging stage and press Acquire.
• Consistent results – Removes operator variability, resulting
in more consistent data.
• More accurate data – By removing physical contact between
the transducer and the animal, tissues are not distorted orwarped during 3D image acquisition.
• Enables widefield imaging – Allows whole-subject imaging forvisualizing effects of disease or therapies on specific organs
or surrounding tissues.
• High speed – Automated hands-free transducers enable fast,consistent scanning.
• Streamlined workflow – Users can prep the next set ofsubjects while the scanner is operating.

3 |Vega® automated, hands-free, high-throughput ultrasound system• Introduction

See more, get more withwidefield ultrasound.

• Hands-free ultrasound• Widefield imaging• High throughput

Unlike traditional ultrasound, the Vega system enables widefield imaging in a single scan—in less than a minute. This unique design
is important for visualizing effects of disease or therapies on organs and surrounding tissues, reducing the risk of missing obscured
pathologies as can happen with conventional handheld transducers. This gives more anatomical context to your ultrasound studies.

• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Example of Vega’s widefield imaging capability showing
detailed anatomy. Coronal plane image reconstructed fromwidefield 3D ultrasound data.

4 |Vega® automated, hands-free, high-throughput ultrasound system• Introduction

Fast, high-throughput ultrasoundwith the push of a button.

• Hands-free ultrasound• Widefield imaging• High throughput• ModesWith its automated transducers integrated under the imaging stage, the Vega system is the fastest ultrasound scanner on the market—
with most scans taking less than a minute. Its three-bay imaging stage enables sequential scanning of three mice at a time, accelerating
your imaging studies even more. And while one set of subjects is being scanned, the next set can be prepped on the benchtop, further
streamlining your imaging workflow.

• Acoustic angiography• Elastography

Three-mouse imaging stage• Applications• SonoEQ™ software• Solutions• Support• Contact us

5 |Vega® automated, hands-free, high-throughput ultrasound system

Many modes, many applications.
• Introduction• Hands-free ultrasound• Widefield imaging• High throughput• ModesCreated for maximum flexibility, the Vega system comes standard with two integrated
transducers for various scanning modes:• A high- and a high/low-frequency wobbler transducer for high-resolution scanning andacoustic angiography vascular imaging• Linear-array transducer for fast deep-tissue imaging, elastography, and cardiac imaging
Detailed view

• Acoustic angiography• Elastography• Applications• SonoEQ™ software

Transducer type

Imaging mode

Wobbler: high frequency• B mode• Tumors• Individual organ systems

Wobbler: high/low frequency• B mode• Acoustic angiography (AA)• Tumors• Individual organ systems• Vascular

Linear array• B mode• M mode• 4D mode• Shear-wave elastography (SWE)• Tumors• Cardiovascular/cardiac function• Assessments of tissue stiffness• Solutions• SupportApplication(s)• Contact us6 |Vega® automated, hands-free, high-throughput ultrasound system

Many modes, many applications.

Detailed view of the transducers• Introduction• Hands-free ultrasound• Widefield imaging• High throughput• ModesCreated for maximum flexibility, the Vega system comes standard with two integrated transducers
for various scanning modes:• A high- and a high/low-frequency wobbler transducer for high-resolution scanning andacoustic angiography vascular imaging• Linear-array transducer for fast deep-tissue imaging, elastography, and cardiac imaging
Detailed view• Acoustic angiography• Elastography• Applications• SonoEQ™ software

Transducer type
Wobbler: high frequency

Imaging mode
• B mode• Solutions• Support

Wobbler: high/low frequency• B mode• Acoustic angiography (AA)• Contact us• B modeLinear array• M mode• 4D mode• Shear-wave elastography (SWE)

Application(s)• Tumors• Individual organ systems• Tumors• Individual organ systems• Vascular• Tumors• Cardiovascular/cardiac function
Close window• Assessments of tissue stiffness

7 |Vega® automated, hands-free, high-throughput ultrasound system• Introduction

Explore microvasculature withacoustic angiography.

• Hands-free ultrasound• Widefield imaging• High throughput• Modes• Acoustic angiography

With acoustic angiography, you can visualize and quantify tumor vessel-networkarchitecture and density or reveal response to therapy before tissue changes.
Through use of injectable VesselVue® contrast agents, acoustic angiography with theVega system enables high-sensitivity imaging of microvasculature, collecting images of
3D microvessel trees in minutes and 2D images in less than a second.

• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Acoustic angiography showing vasculature surrounding tumor.

Acoustic angiography capture ofa mouse kidneys’ vasculature andsurrounding structures.

(Top) A traditional B-mode image showing 2Dand 3D representations of a tumor. (Bottom)
The same tissue as above imaged withacoustic angiography mode.
*Note that the only features seen aremicrovessels in and around the tumor, while
all other tissue appears invisible. This allows
tissue vascularity to be quantified.

8 |Vega® automated, hands-free, high-throughput ultrasound system• Introduction

Measure tissue stiffness withshear wave elastography.

• Hands-free ultrasound• Widefield imaging• High throughput• Modes

Tissue stiffness evaluated through manual palpation has historically been used as a marker to access disease states, but thistechnique is qualitative and doesn’t provide any quantitative measurement behind the disease. Now researchers can assess tissue
stiffness associated with liver fibrosis, renal disease, and much more noninvasively, in a matter of seconds, with the Vega ultrasoundsystem’s shear wave elastography (SWE) capability.

• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Image represents liver stiffness
from a NASH mouse model.
The SWE overlay on grayscale
B-mode provides a window into
the tissue’s mechanicalproperties at that location.

9 |Vega® automated, hands-free, high-throughput ultrasound system

For the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughput

Oncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Oncology• Quantify tumor volume• Visualize tumor in the context ofbroader anatomy• Detect deep-tissue tumor and metastases• Visualize tumor microvasculature

10 |Vega® automated, hands-free, high-throughput ultrasound system

For the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughputOncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact usLiver• Measure liver stiffness• Quantify steatosis• Evaluate liver tumors• Visualize liver vascularity

11 |Vega® automated, hands-free, high-throughput ultrasound system

For the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughput

Oncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Kidney• Quantify kidney volume• Assess changes in kidney perfusion• Study kidney microvasculature

12 |Vega® automated, hands-free, high-throughput ultrasound systemFor the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughput

Oncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Cardiology• Evaluate global systolic function,
including LV ejection fraction, strokevolume, and cardiac output• Use cardiac heatmaps to easily
locate the heart• Perform 3D/4D reconstructions
without ECG• Assess drug toxicity

13 |Vega® automated, hands-free, high-throughput ultrasound system

For the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughput

Oncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Radiation
research• Noninvasively image radiation-inducedchanges to tissue• T rack volumetric tumor response• Evaluate vascular remodeling

14 |Vega® automated, hands-free, high-throughput ultrasound system

For the applications you’re focused on.
• Introduction• Hands-free ultrasoundWith multiple scanning modes, the Vega ultrasound system delivers the flexibility you need to advance your research and drug
development studies. Measure tumor volume, visualize microvasculature, quantify tissue stiffness, evaluate drug cardiotoxicity, and more.
Click the application for further insights.

• Widefield imaging• High throughput

Oncology

LiverKidney

Cardiology

Radiation research

Regenerative medicine• Modes• Acoustic angiography• Elastography• Solutions

Regenerativemedicine• Support• Evaluate scaffold vascular• Contact us• Track cell seeding over time

• Applications• SonoEQ™ software

15 |Vega® automated, hands-free, high-throughput ultrasound system

Visualize, acquire, explore, quantify.
• Introduction• Hands-free ultrasound• Widefield imaging

Built on 3D Slicer, an open-source software platform
for image processing and 3D visualization, SonoEQ™ ishighly intuitive with a user-friendly interface that’s easy
to learn and use. And it delivers:• High throughput• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Quantification tools, including simple linear caliper
measurements• Complex geometrical contouring tools forabnormally shaped structures• A site-wide license so researchers can analyze
data from any location with their personal laptops• Ability to export data in multiple formats, forbetter decisions across your lab• Support• Contact us

16 |Vega® automated, hands-free, high-throughput ultrasound system• Introduction

Discover our wide range of leadingin vivo imaging solutions.

• Hands-free ultrasound• Widefield imaging

Imaging in vivo can have a profound effect on your understanding of molecular and physiological research across a broad range of
disease models, as well as accelerating preclinical development of therapeutics noninvasively, in real time.

• High throughput• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Instruments

Imaging reagents

UltrasoundUltrasound Reagents• Vega® hands-free, automated, high-throughput system
Optical• VesselVue® injectable microbubble contrast agentfor vascular imaging• IVIS® Spectrum 2 series 2D and 3D optical systems with integrated CT*

Optical Reagents• IVIS Lumina S5 and X5 high-throughput, high-sensitivity benchtop 2D
optical imaging systems with integrated x-ray**• IVISbrite™ bioluminescent substrates and cell lines• IVISense™ fluorescent probes, labels, and dyes

• IVIS Lumina III series benchtop 2D optical imaging with integrated X-ray**
MicroCT• Quantum GX3 high-speed, high-resolution, low-dose microCT system* Available on the IVIS SpectrumCT only. ** Available on the IVIS Lumina X5e and IVIS Lumina III XRMS only.

17 |Vega® automated, hands-free, high-throughput ultrasound system

Count on our support.
• Introduction• Hands-free ultrasound• Widefield imaging• High throughput• Modes• Acoustic angiography• Elastography• Applications• SonoEQ™ software• Solutions• Support• Contact us

Our experienced scientists and support experts are here to help you. From application support, training, and troubleshooting to helping you
select the best imaging system for your research, we have the resources you need to get the most out of your in vivo imaging studies.
Application support
Offering worldwide support, our dedicated applications team,with their in-depth scientific knowledge, can help you achieve
your research goals. By offering unmatched support, ourapplication scientists are your main contact for issues ranging fromdevelopment of imaging protocols to training and education.
Training and education
Get the most from your in vivo imaging instrument by learning fromthe experts. We offer basic and advanced training at your facility,
as well as classroom training through In Vivo University, so you canbroaden your knowledge, share with fellow researchers, and learn
from field application scientists.
ServiceOur global service engineers are available to help you withinstallation, preventative maintenance, technical guidance, and any
repair services to ensure your imaging system operates as optimallyas possible to meet your in vivo imaging research goals.

18 |www.revvity.com

Revvity, Inc.
940 Winter Street, Waltham, MA 02451 USA(800) 762-4000 | www.revvity.com
For a complete listing of our global offices, visit www.revvity.com
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