Corporate Guide

The future of health care through truly unique technology

Corporate Message

Your dreams. Woven together.

Our mission is to express our clients’ wishes in a single ultra-fine wire

Leveraging Asahi Intecc DNA to create new value and drive
another era of growth
As an R&D-oriented manufacturer, the Asahi Intecc Group’s mission is to continuously supply number-one products thatcan only be made with our one-and-only technologies. To fulfill this message, we provide a broad range of solutions
that make our clients’ dreams come true and contribute to all of society.
Even in today's challenging environment, we remain committed to speed and integrity in meeting the needs of doctors
and clients. We are focused to this day on technological and on-site capability, which are embedded in our very DNA.
We will continue to deliver unique value, and create new value, by leveraging our unique Asahi Intecc qualities to drivea whole new era of growth.

Kenji Miyata
President & CEO2

We look forward to your continued support in the future.

Corporate History

Highlight 1

Development of the world’s first PCI guide wire for CTO treatment

Highlight 2Acquisition of shares of A-Traction(now ASAHI SURGICAL ROBOTICS CO., LTD.)

Acquisition of shares of KARDIA S.R.L.

Acquisition of shares of Rev. 1 Engineering, Inc.

Acquisition of shares of Pathways Medical Corporation.

Establishment of Global Headquarters and R&D Center(GHQ).

Establishment of Tohoku R&D Center.

Listing on First Section of the Tokyo Stock Exchange andFirst Section of the Nagoya Stock Exchange.

2018

Acquisition of shares of RetroVascular, Inc.
(now ASAHI Medical Tecnoloties, Inc.)

Acquisition of shares ofTOYOFLEX CORPORATION

2013
Establishment of Shizuoka R&D Center.

2011
Massive flooding and swift recovery at Thailand factory. Highlight 2

2006
Establishment of Osaka R&D Center.

Establishment of ASAHI INTECCHANOI CO., LTD.

2005
Listing on Second Section of the Tokyo
Stock Exchange and Second Section ofthe Nagoya Stock Exchange.

1995
Development of the world’s first guide wire totreat CTO (chronic total occlusion). Highlight 1

1988
Changing name to ASAHI INTECC CO., LTD.

Establishment of Asahi Mini Rope Co., Ltd.

Moving to Nagoya.

Manufacturing starts in Sakai,Japan.

1972

1976

Establishment of ASAHI INTECCTHAILAND CO., LTD. as anoverseas production base.

1989

2004
Initial public offering with the JASDAQ Securities Exchange.

Inheriting the ASAHI DNA,and constantly moving forward.

2021

Recovery from the Thailand floods

Bringing new, minimally invasive treatment to the world from Japan

Even in hardship, holding tight to the light at the end of the tunnel

ASAHI INTECC developed the world’s first guide useful forCTO (chronic total occlusion) at the request of a leading
Japanese doctor. We created a guide wire with high-leveltorque response, pushability, and flexibility in order to passthrough the hard plaque that gradually blocks coronaryarteries over a long period of time. This contributed to thespread of minimally invasive treatment not only in Japan,
but around the world.

As a result of the 2011 Thailand floods, production at the factory, ASAHIINTECC’s main plant, was no longer possible. However, all of our employees worked together to carry out production at alternative sites at our Setofactory, Osaka R&D Center, and Hanoi factory. Under these circumstances,
the Thai employees who were dispatched to our Hanoi factory worked with
our Vietnamese employees to keep production going. As a result, theproduction technology capabilities and productivity of our Hanoi factory
improved, and its production capacity increased significantly.

Miracle, the guide wire for CTO treatment

Medical factory inundated with 3 meters of water3

Core Technologies

We leverage our “4 core technologies & more” to meet sophisticated needs.
Wire RopeWire

O 0.03 mm

StrandStrand Core

O 0.09 mm O 0.27 mm O 0.81 mm
A strand consists of wires woven together with acentral strand that is thinner than a hair at 0.03mm
in diameter. The strand core at the center of thestrand also consists of six strands woven together.
For example, a 0.81mm wire rope is made up of343 wires woven together.

4 core technologies & more
Wire drawing technology

The technology to make various types ofstainless steel wire into the wire diameterand strength that suits the purpose.

4

Wire forming technology

The technology to process wire intowire rope and coil with high precision.

We are further expanding our core technologies.

Coating technology

The technology to apply coatings suchas resin and PTFE to wire rope and coilat the micron level.

Torque technology

The technology to give wire and wirerope an ideal torque response.

Laser processing technologies

Die & Injection molding technologies

We are also engaging in external
technical collaboration.
Robotics

AI technologies

High-speed network technology

Business Areas

We create innovations with “ASAHI Technology”
to meet the needs of professionals around the world.
From its inception, ASAHI INTECC has been manufacturing wire ropes used forindustrial equipment, and it currently expands its business areas to medical devices.
We supply “number one” products manufacturing by “one-and-only technologies”
to our clients.

IndustrialEquipmentASAHI BrandProducts

IndustrialComponents

4 Core Technologies & More

MedicalComponents

MedicalDevices

OEM & ODMServices5Business Areas: Industrial Equipment

ASAHI INTECC develops high-functioning and quality industrial equipmentusing technologies cultivated since its establishment.
In the field of industrial equipment, we supply synchromesh wire ropes, cable racks, andother wire products with diverse functions.

Synchromesh Wire Ropes

Cable Racks

Torque Wire Ropes
6OA equipment (copier drive wire)

Housing materials(window opening and closing unit)

Home applications(vacuum drive wire for self-cleaning air conditioner)

Automobile parts(opening and closing mechanism for sliding doors)

Leisure items (fishing line)

Sporting goods (wire for golf shoes)

Business Areas: Medical Devices 1

ASAHI INTECC delivers components and products that are optimized forsophisticated needs to the world’s medical device manufacturers.
Medical Components

OEM & ODM Services
We employ renowned “ASAHI Technology” to provide OEM andODM services to medical device manufacturers around the world.

Cable tubes

Guide wires for customers’ devices

Wire ropes

Sensor guide wires

For sheathesFor lower limb
blood vessels

Laser processing

Interventional guide wires

Various catheters and therapeutic devices
7

Business Areas: Medical Devices 2 —ASAHI Brand Products—

In addition to products for cardiovascular and various other vascular treatments,
ASAHI INTECC has developed products for use in gastrointestinal treatment.
We have developed a variety of devices used in endovascular treatment, which include our world-leading cardiovascular devices as well as those forneurovascular, peripheral vascular, and abdominal vascular treatment. Recently, we have also developed products used in gastrointestinal endoscopy.

Intravascular field

Neuro interventions
Neurovascular guide wires

Coronary interventions

Gastrointestinal field

Neurovascular guide catheters

PCI guide wires

Interventional radiology
IVR guide wires

Endoscopy

IVR microcatheters

Biliopancreatic guide wires

PCI guide catheters

Peripheral interventions
Peripheral guide wires

PCI balloon catheters

Peripheral penetration catheters

Bile duct stone removal
PCI treatment

8Stroke treatment

Doctor Interview

We aim to pioneer new minimally invasive treatments based on feedback fromdoctors around the world.
Cardiovascular Field

Gastrointestinal FieldWilliam L. Lombardi, M.D.

Prof. Junbo Ge

Kei Ito, M.D., Ph.D

Clinical Professor, Medicine, Division of Cardiology
Director, Complex Coronary Artery Disease Therapies
University of Washington Medical Center

Academician of Chinese Academy of Sciences
Director of the Department of Cardiology
Zhongshan Hospital, Fudan University

Director of Center of Gastroenterology
Sendai City Medical Center

I think with the move of ASAHI to ownership of their guide wires and their microcatheter, we are going to see much more knowledgeable sales people who aremore vested in the success of that technology. And I think that we, hopefully, will
see ongoing investment in research and physician education via in some ways
in one nimble sales force.

I guess, maybe in the next years, PCI in the whole of China should be over three
million because it’s now nine hundred twenty-five thousand cases last year.
Therefore, I think we have a lot of things to do, we have to train our colleagues,
especially the young colleagues to encourage them to get involved for coronary
intervention. And the more local hospitals, especially in the county hospitals,
also now got involved to handle acute myocardial infarctions, especially forprimary PCI’s.

I am quite impressed by the ability and speed at which ASAHI transfers its
technologies accumulated in the cardiovascular field to the field of gastroenterology. They have a corporate culture that allows many engineers to openly
express their opinions and rack their brains together to solve problems. I believethat ASAHI is a company capable of choosing the optimal path in this way.

We have listened to feedback from doctors at academic
conferences held all over the world.

Neurovascular Field

Demetrius K. Lopes, M.D.

Prof. Dr. René Chapot

Surgical Director
Director of Cerebrovascular Surgery and theComprehensive Stroke Program
Advocate Health Care

Head of Department of Neuroradiology and Radiology
Alfried Krupp Hospital

CCT (Japan)

ASAHI technology is something that was for me very much synonym of a great
technology and a great product. I always felt that the quality that was associatedto ASAHI was always a very high standard. This became very true when I started
using a lot of the ASAHI products. You start getting the reliability and the consistency of the products.

SCAI (USA)As the volume of procedures on increasing a lot, we need much more specialized products such as balloon guiding catheters and smaller wires. We need thewires that is getting the aspiration catheter to be navigated more easily.
There’re so many things to do, and I’m sure that soon we have a new family ofproducts coming out by ASAHI.
CIT (China)

9

Business Globalization: Sales Structure

We have built a global sales structure to supply our products
in more than 110 countries and regions.

Staff at each of our bases gather comments from doctors through academic conferences and hospital visits and provide feedback tothe Global Headquarters and R&D Center.

ASAHI INTECCEUROPE B.V.

ASAHI INTECC
Deutschland GmbH

Global Headquarters and R&D Center

Asahi Intecc CIS LLC

Hong Kong
BranchAsahi Intecc
Scientific (Beijing)Co., Ltd.

Shanghai
BranchGuangzhou
OfficeTokyo Office

ASAHI INTECC USA, INC.
Asahi Intecc
J-sales, Inc.

France Branch

KARDIA S.R.L.

Korea Branch
Thai
BranchMiddle East Branch

10India Branch

Singapore Branch

Taiwan Branch

ASAHI INTECC LATIN
PROMOCAO DE VENDAS
LTDA.

Business Globalization: R&D System
Global Headquarters andR&D Center
Product Development & Prototyping

We are building a global R&D system, keeping watch
on the dynamically changing global medical market.
ASAHI INTECC
USA, INC.

ASAHI MedicalTechnologies, Inc.

R&D for the US market

State-of-the-Art R&D

Simulation room that reproduces the cath lab

Developing peripheral catheters in highdemand in the US market.

Gathering technological information from Silicon
Valley and developing its unique devices.

We welcome doctors from all over the world to evaluate
prototypes and provide training.

ASAHI INTECCTHAILAND CO., LTD.

Tokyo R&D Center

Product improvement &Production technology development

Osaka R&D Center

Shizuoka R&D Center

Material Development

Resin Development

Developing product improvements andproduction technology by taking advantage ofproximity to the production site.

Conducting research into wire-related metals
and cutting-edge materials.

Conducting research into resin materials
used in catheters.

Next-Generation
Smart Technology Development

Tohoku R&D Center

Conducting R&D into industrial device
technologies and next-generation medical
device technologies such as smart medicine
and medical robotics, as well as serving as abase for open innovation.

Conducting research into high-precision
processing technologies, including die andinjection molding.

High-precision processing

11Business Globalization: Production System

The three production sites work together closely to ensure a stable supply ofhigh-quality products.

From the perspective of Business Continuity Plan (BCP), we have decentralized production sites to build a mutually complimentary production system.
ASAHI INTECC HANOI CO., LTD.

TOYOFLEX CEBU CORPORATION

Second Asahi Intecc Group production site. Taking overproduction from the Thailand factory to increase
production efficiency.

ASAHI INTECC THAILAND CO., LTD.

Third Asahi Intecc Group production site. Taking overproduction from the Hanoi factory, operates a systemenabling production of medical equipment as well as
industrial equipment.

Main Asahi Intecc Group factory. Engages in integrated
production from materials. Currently plays a role not only in
production, but also in development of product improvements
and production technology.

12

Business Globalization: Quality Control System & Global Regulatory Affairs System

We apply the same standard of quality control to all of our basesaround the world to meet the expectations of customers.
In order to guarantee the high quality required for medicaldevices, we supervise development and production sites,
perform timely quality control, and also maintains andadministers for International standards.

Bases

ASAHI INTECC CO., LTD.
ASAHI INTECC THAILAND CO., LTD.

We have assigned regulatory affairs personnel around theworld to engage in the work tailored to the circumstances ofeach country and region.

Environmental management
systems certifications

Quality management system certifications

ASAHI INTECC HANOI CO., LTD.
ASAHI INTECC USA, INC.
Filmecc Co., Ltd.
Nihon Chemical Coat Co., Ltd.
TOYOFLEX CEBU CORPORATION

Medical Division•EN ISO 13485 / ISO 13485•MDSAP•EN ISO 13485 / ISO 13485•ISO 9001•MDSAP•EN ISO 13485 / ISO 13485•ISO 13485•EN ISO 13485•ISO 9001
Medical Business•
EN ISO 13485 / ISO 13485

Device Division•
EN ISO 13485 / ISO 13485

Osaka R&D Center•
ISO 14001
Device Business•ISO 14001

•————

MDSAP

Device Business•ISO 9001

Device Business•ISO 14001

Russia
EU

China

Korea
USA

India
TaiwanMiddle East
VietnamThailandPhilippines
BrazilSingapore

13

Company Profile

Company NameBusiness Operations
Representative
Date of Establishment
Account Settlement

ASAHI INTECC CO., LTD.
Development, manufacturing and sale of medical devices
Development, manufacturing and sale of ultra-fine stainless steel wire ropes, terminal processed products, etc.
Kenji Miyata, President & CEO
July 8, 1976
End of June (once a year)

Capital18,860.79 million yen (as of June 30, 2023)

Number of Employees

ASAHI INTECC CO., LTD.: 1,016 persons
Consolidated: 10,187 persons(as of June 30, 2023, excluding part-timers)

Stock listing

Head Office

Tokyo Stock Exchange Prime Market
Nagoya Stock Exchange Premier Market(securities code: 7747)

To Osaka

JRoChuKozoji StationeLinnaiShor

iveaRw-ga

Nakamizuno-cho

Shidami JuniorHigh School
Seto Shimin
Park3-100 Akatsuki-cho, Seto-shi, Aichi 489-0071 Japan
TEL : +81-561-48-5551
FAX : +81-561-48-5552

Aichi Prefecture
Forest Parku SetoMeitets

Line-sen

SekoHaruoka

Aichi Medical
University Hospital

To Nagoya Station

Iriga-ike Pond

14

Tomei Nagoya
Interchange

ine

About 20-min ride by taxi from Kozoji Station on the JR Chuo line,
accessible from JR Nagoya Station

YadInaba-chopL

About 10-min ride by taxi from Shin Seto Station on the Meitetsu
Seto Line, accessible from JR Nagoya Station by transfer at Sakae
Station on the Higashiyama subway linerRiveoo•

waa-gaLhi

Access using public transportationoa KaidChiyodAicTaiikukan-Minami•

Tosei GeneralHospital

Shin Seto Station

Aichi Prefectural University

Introduction to Global Headquarters and R&D Center
Overview

To ensure fast development of innovative technologies, we consolidated our head
office functions into the research and quality assurance division. With facilities
and functions, we will welcome doctors and clients from all over the world.

—Address: 3-100 Akatsuki-cho, Seto-shi,
Aichi 489-0071
Building area: 2,000m2
Floor area: 14,000m2
Structure: Heavy gauge steel structure,
7 floors above ground
Completed: December, 2018
Commenced operation: December, 2018

1F

3F

It shows our global activities, technologies and history inheriting the founder’s passion and ASAHI DNA.

This space can be freely modified to suit the project team in order todevelop innovative new products.

INNOVATION GATE (Showroom)

Product Development Project Booth

7F

Cafeteria

Research and development area

GHQ Cath lab

Convention Hall

Having installed the Cath lab system and the original human bodymodel, it makes possible to experience our technologies and products ina similar way to a clinical setting. ASAHI TRAINING
ACADEMY provides doctors with new product training.

We have installed a movable 200-seat banked seating stand for use inmeetings and gatherings. This allows a variety of layouts. The projection
system can also be used for videoconferencing with bases around theworld and the simulation room.

2F

Communication Floor

GHQ StudioThis floor is designed differently than the Office Floors to serve as aspace for stimulating internal communication such as, breaks and study
meeting.

We shoot and edit the original contents such as simulation using andGHQ Cath lab and interviews with doctors, and disseminates them
globally in a timely manner.

Refresh SpaceLaboratory

4F - 6F

Based on the concept of “greenery + health + communication,” RefreshSpace used for the multi-purposes such as casual meetings.

Office Floors

Fitness Gym

For smooth communication and speeds up our operations, we haveconsolidated our development, quality assurance, sales and marketing,and head office management divisions into a single location.

We have installed a range of equipment in consideration of employee’s health.

152022.04