SUMMARY OF MAJOR
MODIFICATIONS AND
EXPLANATORY NOTES
2021 Prohibited List
Redesign of the List
• The 2021 Prohibited List is redesigned to improve navigation and usability.

Specified Methods• M2.2 is now a Specified Method in accordance with Article 4.2.2 of the 2021 World Anti-Doping
Code (the Code).

Substances of Abuse• Article 4.2.3 of the Code defines Substances of Abuse as those “Prohibited Substances which
are specifically identified as Substances of Abuse on the Prohibited List because they arefrequently abused in society outside of the context of sport.”• Cocaine, diamorphine (heroin), methylenedioxymethamphetamine (MDMA/“ecstasy”) andtetrahydrocannabinol (THC) are designated as Substances of Abuse.
• Other substances are currently under review and may be designated as Substances of Abusein the future.

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SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES(IN- AND OUT-OF-COMPETITION)

PROHIBITED SUBSTANCES
S2. Peptide Hormones, Growth Factors, Related Substances and Mimetics• Transforming growth factor-beta (TGF-β) signalling inhibitors are now included with their fullrather than abbreviated name.
• IOX2 is added as an example of a hypoxia-inducible factor (HIF) activating agent.

S3. Beta-2 Agonists• Inhaled vilanterol is now permitted up to the manufacturer’s maximum recommended
dose. The dose is expressed as the metered dose of 25 micrograms which is equivalent to adelivered dose of 22 micrograms.
• It is clarified that arformoterol and levosalbutamol are prohibited by adding them as examples.

S4. Hormone and Metabolic Modulators• Sub-classes 4.2 and 4.3 were amalgamated to become anti-estrogenic substances (including
selective estrogen receptor modulators (SERMs)). This clarification in terminology reflects
that, for anti-doping purposes, all these substances act by a common mechanism of binding
to estrogen receptors and blocking estrogen action. This clarification did not add or remove
any substances from this category.

S5. Diuretics and Masking Agents• The wording regarding the exception to allow the ophthalmic use of carbonic anhydrase
inhibitors is clarified as “topical ophthalmic administration”.

PROHIBITED METHODS
M2. Chemical and Physical Manipulation• As explained above, M2.2 is changed from a non-Specified to a Specified Method.
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SUBSTANCES AND METHODS PROHIBITED IN-COMPETITIONPROHIBITED SUBSTANCES
S6. Stimulants• Examples of imidazole derivatives for topical use are added to the exceptions. These arebrimonidine, clonazoline, fenoxazoline, indanazoline, naphazoline, oxymetazoline andxylometazoline.

S9. Glucocorticoids• Additional examples of glucocorticoids are added to the List. The names of some existing
examples are clarified to better reflect the active drug compound.
• As proposed in the draft 2021 Prohibited List circulated for consultation to stakeholders inMay 2020, WADA’s Executive Committee approved, at its 14-15 September 2020 meeting,prohibiting all injectable routes of administration of glucocorticoids during the In-Competition
period. Examples of injectable routes of administration include: intravenous, intramuscular,periarticular, intra-articular, peritendinous, intratendinous, epidural, intrathecal, intrabursal,intralesional (e.g. intrakeloid), intradermal, and subcutaneous. However, in order tothoroughly and widely communicate the rule changes and to allow sufficient time for
information and education, the Executive Committee decided to introduce the prohibitionof all injectable glucocorticoid routes and the implementation of the new rules on
1 January 2022. This one-year period will allow, for example, Athletes and medical personnel
to get a better understanding of the practical implementation of the washout periods,
Laboratories to update their procedures to incorporate the revised and substance-specific
new reporting values, and sports authorities to develop educational tools for Athletes,
medical and support personnel, addressing the safe use of glucocorticoids for clinicalpurposes in anti-doping.

P1. Beta-blockers• Nebivolol was added as an example.

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MONITORING PROGRAM
Beta-2 Agonists: In and Out-of-Competition:• Any combination of beta-2 agonists was removed as the required prevalence data wereobtained.
• Findings for salmeterol and vilanterol below the Minimum Reporting Level are included in theMonitoring Program to better monitor their therapeutic use vs risk of abuse.

* For further information on previous modifications and clarifications, please consult theProhibited List Q & A at www.wada-ama.org/en/questions-answers/prohibited-list-qa.

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