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MANTIS®

conserve your reagents andyour budget
The MANTIS® is a programmable, low volume,
low dead volume, non-contact liquid dispenser
that can reliably dispense a variety of solutions
including those containing beads, cells,
proteins, enzymes, probes and master mixes.

Broad Range of Applications
NGS Sample Preparation

Cell-based Assays

Real-time and Digital PCR Workflows

Assay Development and Optimization

Enzyme-Linked Immunosorbent Assays (ELISA)Key Features
Low Dead Volume - dead volumes can be reduced to just 6 µL by using pipette tips as reagent reservoirs
Clean - the fluid path is both disposable and washable
Reliable - non-contact micro-diaphragm technology dispenses using positive displacement with minimal risk of clogging
Flexible - the MANTIS can dispense into 24-, 96-, 384-, and 1536-well formats with the ability to create custom,
non-standard plate templates quickly and easily
Chemical Compatibility - the MANTIS can dispense DMSO and other harsh solvents using optional perfluoroelastomer chips

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Rev: 02Dec22-0101

Conserve Reagents
To minimize dead volume, reagents plug directly into themicrofluidic chip. Dead volumes are further reduced to just
6 μL by using pipette tips as reagent reservoirs, making
the Mantis ideal for dispensing even the most precious
reagents. Unused reagent can be recovered to source
reservoirs upon completion of a dispense run.

direct pipette tip dispenses reduce
dead volumes to just 6 μL

large micro-diaphragmState-of-the-art Dispensing
Technology

input valve

At the core of the MANTIS® is a microfluidic chip with a valve
cluster that measures and dispenses discrete volumes ofliquid. This valve cluster has two micro-diaphragms (selecteither 100 nL and 500 nL or 1 μL and 5 μL) that can fill anddispense as rapidly as 10 times per second.

output valve
small micro-diaphragm

MANTIS chip and micro-diaphragm technology

User-friendly Software
The MANTIS software provides a straightforward,
user-friendly way to design even the most complicateddispense protocols in a matter of minutes. The software
integrates with Microsoft Excel and allows easy importingof dispense lists from CSV files.

Integration Friendly
The MANTIS can easily be integrated with robotic plate
handling solutions with an automation API designed forfully automated control of the dispensing process.
MANTIS software with 6 reagents set up
for dispense

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Rev: 02Dec22-0101

Customizable to Meet Your Needs
Multiple Chip Changer (MCC)
MANTIS® can automatically dispense up to 6 reagentsto create complex plates and assay development
protocols.

up to 6 reagents can automaticallybe dispensed with the MCC option

Continuous Flow Dispensing
Using the continuous flow option, the MANTIS candispense volumes from 5 μL -> 1000’s of μL in acontinuous stream, perfect for deep well blocks.
Continuous flow options are available to fit standard 50
mL Falcon tubes, 250 mL Nalgene bottles and Schott
Duran GL45 Bottles.
Radio-Frequency Identification (RFID)
Chips Automatically track all your chip usage data
including micro-diaphragm cycles and dispense history.
That RFID tracking warns users when chips are due tobe replaced, ensuring optimal performance across chiplifetime.
Automated Washing
MANTIS has built-in dual wash stations for easy fluid
pathway cleaning following dispenses.

built-in dual wash stations for easy cleaning

Large Capacity Chip Changer (LC³)
The LC³ upgrade vastly expands the number of reagentsthat can be automatically dispensed by adding a
modular carousel for up to 24 chips. The addition ofa second LC3 unit expands the capacity to up to 48
different reagents.

up to 48 reagents can automaticallybe dispensed with the LC³ option

Copyright 2021 FORMULATRIX®.

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www.formulatrix.com+1 781 788 0228

Rev: 02Dec22-0101

User Account Management System
The MANTIS software allows seamless operation in regulatory environments including controlling user access and tracking userhistory. Our user management system will help you run your MANTIS dispenser in GLP, 21 CFR Part 11, or other regulatory environmentsby controlling user permissions and storing an official audit trail for your records.
Here are some key benefits of the MANTIS 21 CFR Part 11 “capable” software:

User Account Management
Restrict user access and instrument control by locallydefined permission levels
Lock users after failed login attempts
Set and manage password requirements
Archive old users, keep all user records

User account management system

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Secure Audit Trail Logging
Date and time stamped user-action and instrument
action records
Full instrument and user-action electronic records
are stored in a secure database
Export log files to password protected PDFs
Selectively manage log elements included in youraudit trails
Audit trails maintained for the lifetime of theinstrument

www.formulatrix.com+1 781 788 0228

Rev: 02Dec22-0101

Specifications and Requirements
Computer Specifications
Microsoft Windows Vista, 7, 8, or 10; 32- or 64- bit
Dual Core x86 or x64 1.5 GHz processor
1 built-in USB port (USB 2.0 recommended, USB 3.0 supported)
4 GB RAM
1 GB Hard Drive space
768 pixels vertical minimum screen resolution (900+ pixels recommended)
Electrical Specifications
110 V - 240 V, 50 Hz - 60 Hz, 50 W typical, 150 W max. Standard or European outlet
Environmental Requirements
4-40 °C ambient temperature
85% or less relative humidity
4,000 m maximum altitude
MANTIS Physical Dimensions
Width: 350 mm or 13 25/32” (smaller without ACC or reagentholders)
Height: Full Extension: 232 mm or 9 9/64” (not includingpipette tip input)
Height: No Extension: 192 mm or 7 9/16” (not including
pipette tip input)
Depth: 212 mm or 8 11/32”
Weight: Approx. 5.2 kg (11.5 lbs)
Microfluidic Chip Options
A variety of dispensing chips are available including certified molecular biology grade chips and chips that are compatible with harshsolvents.

Chip Type

Diaphragm Vol.

Min Vol.

Max Vol.

Pulses per Second

Dead Vol.

CV’sLow Volume

0.1μL + 0.5μL

0.1 μL∞@ 0.1 μL: 10, @ 0.5 μL: 76 μL<3% at 0.1μL

High Volume

1 μL + 5 μL

1 μL

∞

@ 1 μL: 10, @ 5 μL: 415 μL<3% at 1μL

Continuous Flow

N/A5 μL∞

dispenses up to 600 μL / sec

150 μL

<3% at 5 μL

For more information about the MANTIS, visit us at www.formulatrix.com or email info@formulatrix.com

Copyright 2021 FORMULATRIX®.

All Rights Reserved.

www.formulatrix.com+1 781 788 0228

Rev: 02Dec22-0101