╙䋳࿁ 㘩䈱቟ో䈫ஜᐽ䉲䊮䊘䉳䉡䊛ᐔᚑ㪉㪋ᐕ㪈㪉᦬㪌ᣣ ᄢች䉸䊆䉾䉪䉲䊁䉞ȏȊȓȩǿǱƱƸᲹ
Sparassis crispa Wulf.:Fr. ă Sparassis latifolia Y.C. Dai & Zheng Wangβ၃щǢȃȗƴஇᢘᲛǰȫǫȳ᭗ԃஊǭȎǳ᣼ဃỉἡἜἥἻἑἃȏȊȓȩǿǱƷೞᏡࣱ‫׎‬ϋὉ‫ٳ׎‬σỆᵊˡወႎễ᫢ኺ᬴ầẝỦ᫢ԼểẲềஊܹʙᝋỉ‫إ‬ԓỊễẟᵌɶ‫׎‬ȷ᪡‫׎‬ưƸᕤဇƖƷƜƱƠƯදႸ.
഑቟ưƸMedical Mushroom ƱƠƯᛐჷƞǕǔŪ ٰ‫ܓ‬ƴǫȩȞȄǍǢǫȞȄሁƷᤆᓶ೔ƴႆဃƢǔ‫׹ٻ‬ƷƖƷƜἸἝἓỽఇࡸ˟ᅈဃ෇ͤࡍʙಅᢿ௡ƸƍƘƭǋ௑ЎƔǕƠᑶƼǒཞƴᕓƘඬ৙ƭƜƱƔǒ഑቟ưƸECWNKHNQYGTOWUJTQQO ȷɶ‫׎‬ưƸ似ྶᓏ ƱƍƏŪ ଐஜɶ‫׎‬᪡‫׎‬ȨȸȭȃȑȭǷǢ҅቟ƴЎࠋƠƯƍǔƕᆇ‫ࣱݲ‬ƕ᭗Ƙ፦ԛƳ᫢ဇƖƷƜƱƠƯ᣼ဃƷƖƷƜƸྦྷ᣻ƞǕǔŪ ཯ཎƳഫƝƨƑƕƋǓૼƠƍ᫢஬ƱƠƯǋဃᮗԼƕදႸᲛᲛ12ȏȊȓȩǿǱƷဃင߻ᆉȦȋȁǫȏȊȓȩǿǱƱƸᲹɟᑍႎễ᫢ဇẨỉẮỉఎؔỉ૾ඥ1. ҾஙఎؔೞᏡࣱӏƼဃငɥஇǋΟǕƨᓏఇǛȦȋȁǫȏȊȓȩǿǱƱƠƯఎؔƠŴǵȗȪȡȳȈǍь߻᫢ԼƴМဇ3ؔ‫ؕע‬஬ᡵ᧓ᡵ᧓ӓᆫᐯᅈ߻‫ئ‬ƴƓƚǔఎؔɥƷཎࣱǛᄩᛐဃᏋᡵ᧓ႆဃϼྸƓǑƦȶஉؔ᫱੗ᆔൈᓏȓȳᛄؔ‫ע‬ᛦᙌᐯᅈ߻‫ئ‬Ệềဃင‫ؔ޳ݣ‬᫱Ǎ4#2&ЎௌƴǑǔΟᑣᓏఇƷኒወᜤКΟᑣᓏఇƷᢠ৷

2-1. ᘥఎؔ
2-2. ȓȳఎؔ

2. ᓏ࠿ఎؔᥛ‫ސ‬Ქ௿᫱Ў4ȏȊȓȩǿǱƷ঺ЎȏȊȓȩǿǱƷ‫ܤ‬μࣱἸἝἓỽ ἡἜἥἻἑἃỉ঺Ўίʑ༞ᵏᵎᵎᶅẝẺụὸ䃂 ࣱ࣯൒ࣱίᵪᵢᵓᵎὸᾉᵓᵊᵎᵎᵎᶋᶅᵍᶉᶅˌɥṼ ቩࢲửࣇኬ҄Ẳᵊᵆᵏᵎ᷈ᶋᵇᴾஊј঺ЎᶾᵋἂἽỽὅỉਁЈྙửӼɥᵏᵊᵎᵎᵎᶋᶅᵍᶉᶅẆᵐᵖଐ᧓ỉઅ᫢ỂီࠝễẲ䃂 ᢡˡཎࣱ ᾉࣄ࠙ᆳ໱‫ီ٭‬ᚾ᬴ᨏࣱ௨ᑥ˳ီࠝᚾ᬴ ᨏࣱ‫ݱ‬ఋᚾ᬴ ‫ݱ‬ఋᛔႆ˺ဇễẲ䃂 സသᠾᕤᾉസသᠾᕤἯἊἘỵἨἼἋἚСࡇỆᢘӳ䃂 ᆔᒁඥỆấẬỦ ẒԼᆔႇ᥵ẓ ỉ‫ݣ‬ᝋẨỉẮᵑᵐᆔ᫏ỉɟếểễỦᵆᵐᵎᵎᵒ࠰῍ᵇ‫↝˳ܱ܇‬᫢Լᘓဃᚾ᬴ኽௐЎௌᚾ᬴᪮Ⴘኽௐ౨Јᨂမ૾ඥ
ἤእ(AS2O3ểẲề) ౨ЈẶẵ
0.1ppm Ҿ‫܇‬Ԉήࡇඥ᣻᣿‫(ޓ‬PbểẲề)౨ЈẶẵ
1ppm ᄑ҄ἜἚἼỸἲൔᑥඥɟᑍኬᓏૠ(ဃᓏૠ) 3ᶣ103ˌɦ/g೅แ݊‫࠯ټ‬ெؔ᫱ඥ‫ٻ‬ᐂᓏ፭
ᨏࣱ/2.22g
BGLBඥ᎑༏ᑻᏘᓏૠ300ˌɦ/g೅แ݊‫࠯ټ‬ெؔ᫱ඥṼἡἜἥἻἑἃỉ঺ЎỉҞЎᡈẪỊᶾᵋἂἽỽὅᵌᴾẲẦờẆẸỉᵕᵎᵃˌɥầβ၃ᛦૢ˺ဇầ᭗ẟểẟỪủỦᶾᵋᵏᵊᵑᵋἂἽỽὅನᡯ
ṼỴỾἼἁἋ᫏ỆԃộủỦ‫ီ٭‬ҾཋឋẐỴỾἼἓὅẑỊ౨ЈᨂမˌɦǪࠣ࡞ࠞࡦ᛽಴₸ 䃂 ʣࣱ࣯൒ࣱᾉἻἕἚ
ㅢᏱ☳⎈ἡἜἥἻἑἃᶾᵋἂἽỽὅỉನᡯ೉ࡸ‫׋‬ᶾᵋᵏᵊᵑᵋᶾᵋᵏᵊᵔᵋ
5ᶾᵋᵏᵊᵐᵋ

ᓸ⚦ൻḵᵑᵊᵔᴾᵥᶊᶁ ᵏḵЎ‫ޟ‬ᢿḵᵐᵊᵑᴾᵥᶊᶁ ᵏḵЎ‫ޟ‬ᢿ6ೞᏡᚸ̖ƴ᧙Ƣǔ‫إ‬ԓ ĭೞᏡᚸ̖ƴ᧙Ƣǔ‫إ‬ԓ Ĭ

Ὁ Jpn.J.Cancer Chemother. (2004)∝ᏽၨ‫ف‬഻৮С˺ဇ৴ኄ‫ބ‬၏˺ဇ

∝ⅻ⇂᠃ᆆ৮С˺ဇὉ Biol. Pharm. Bull. 2009 Feb;32(2):259-63.

(⚻ญᛩਈ)∝ᘉሥૼဃ৮С˺ဇὉ Biol. Pharm. Bull. 2009 Feb;32(2):259-63.

∝৴⇈−∑⇔∞˺ဇὉ Jpn. J. Cancer Chemother. (2004)

Ὁ Am. J. Surg. 2009 Apr;197(4):503-9.

∝፦ႉ˺ဇὉ Biosci. Biotechnol. Biochem. 71(7), 1804-1806(2007)∝৴‿⁄⁅″˺ဇὉ Biosci. Biotechnol. Biochem. 71(7), 1804-1806(2007)∝৴ᣠ҄෇ࣱ

Ὁ 128th Ann. Meeting of Pharm. Soc. Jpn. (2008)∝ኄ‫ބ‬၏ોծ˺ဇ

Ὁ Journal of Health Science 56(5)541-546(2010)∝ִɦ„‒̝ᡫોծ˺ဇ

䊶 Nishi-Nippon Branch of The Myco. Society of Japan(19)17-22(2009)∝ૼᙹཋឋ੕ኧ

䊶Biosci. Biotechnol. Biochem., 73, 228-229 (2009).

100500%

2.2%

5.0%

ࡂ࠽ࡆ࡜࠲ࠤਃၶȞǦǹƴȏȊȓȩǿǱƱǢǬȪǯǹ
Ǜᡵ᧓ኺӝ৲ɨ OIMIFC[᳕ᇹ‫ ׅ‬ଐஜᙀ‫ˊܦ‬ஆҔၲ‫ ࠰ ˟ܖ‬᳗ȏȊȓȩǿǱǛชьƠƨ᫫૰Ǜᡵ᧓৲ɨƠƨኄ‫ބ‬၏ȢȇȫȞǦǹ --#[ Ʒᆰᐃ଺ᘉኄ͌ŵ᳕ᇹ‫ ׅ‬ଐஜ᫢Լᅹ‫ ࠰ ˟ܖ߻ܖ‬᳗

78ǳȩȸǲȳငဃ̟ᡶ˺ဇ 㫀㫅㩷㫍㫀㫋㫉㫆ᚾ᬴ȏȊȓȩǿǱƷ፦Ꮋ˺ဇᚸ̖˂ỿἠἅểỉൔ᠋․••‣‪•‣ •‣…•‣․•‣••‪••…•․••⇙∏∞⇘∙ငဃ ጞዜᑻኬᏘ≋ኬᏘⅱ↎↹≌‫ف‬഻໯ชь

ȷKPXKVTQᚾ᬴ȷલ˩ᎊ҄ȩȃȈငဃྙ≋‫ف‬഻ྙ≌≉ἅἻὊἄὅငဃྙίᵃὸ

Ūǳȩȸǲȳငဃ̟ᡶ˺ဇ

ᵏᵖᵎ
ᵏᵔᵎ
ᵏᵒᵎ
ᵏᵐᵎ
ᵏᵎᵎ
ᵖᵎ
ᵔᵎ
ᵒᵎᵐᵎ
ᵎ

ŪƠǘ࢟঺ʖ᧸јௐƷӧᏡࣱᘉሥૼဃ৮С˺ဇ⃸ᚾ૰ຜࡇ≝Ҿ஛੭ም․ ⁙‡ ‾͌↞໯ชь‣••‗↗ↆ↎଺↝Ⴛ‫ࣱ෇ݣ‬

ȷ/CVTKIGN 2NWIඥ༏൦ਁЈཋ̓ᚾↆ↎Ӳᆔ᫢ဇ⇓⇴⇙↝ɶ↖⇵⇰⇹∏⇥⇗↞இ↱ࢍⅳ⇙∏∞⇘∙ငဃ̟ᡶ෇ࣱ⇁ᅆↆ↎ŪȒȈᚾ᬴ȷ൦Ўᔕ૝᣽˳ज़ᚸ̖༏൦ਁЈཋ⇵⇰⇹∏⇥⇗༏൦ਁЈཋ↞ຜࡇ̔‫܍‬ႎ↚⇸⇮ႝᐎጞዜᑻኬᏘ‚⁀›‶‸ኬᏘ‛↝‫ف‬഻⇁̟ᡶↆ„‒ɫ↓‣ኬᏘ࢘↹↝⇙∏∞⇘∙ငဃᏡ⇁Ӽɥↄ↊↎910ᘉሥૼဃ৮С˺ဇǳȩȸǲȳငဃ̟ᡶ˺ဇલ˩ᎊ҄ȢȇȫȩȃȈǬȳǬȳVEGF

ᘉሥૼဃ(Angiogenesis)ểỊᾎᘉሥǛƭƘǔਦˋǛӖƚǔǻȳǵȸ
(Ӗܾ˳)

㪉㪌

䋨mg/20cm2䋩⊹⤏ਛ䈱䊍䊄䊨䉨䉲䊒䊨䊥䊮㊂‣••‒ₜ⁙‡ ‾0䊊䊅䊎䊤䉺䉬ࠕࠟ࡝ࠢࠬὉ 60 th Ann. Meeting of Jpn. Soc. Nutr. Food Sci. (2006)∝оͻ඙ၷ̟ᡶ˺ဇ

‣•••‒ₜ⁙‡ ‾Ὁ Food Sci. Tech. Res. (2008)(14)589-594∝⇙∏∞⇘∙ӳ঺̟ᡶ˺ဇ໯ชь



*150

‣•‒ₜ⁙‡ ‾⣲≌ᛥ೙₸ 200

*p < 0.05*‣••‒ₜ⁙‡ ‾ⓨ⣻ᤨⴊ♧୯(mg/dL)250

Ὁ Biol. Pharm. Bull.33(8)1355-1359(2010)䃂 2ဳ♧ዩ∛䊝䊂䊦䊙䉡䉴䈱ⴊ♧୯䉕ૐਅ

Ὁ 66 th Ann. Meeting of JCA (2007)‣•‒ₜ⁙‡ ‾䃂 Ꮢ⽼䉝䉧䊥䉪䉴⵾ຠ䉋䉍䉅 㜞䈇᛫⣲≌૞↪ (⚻ญᛩਈ)Ὁ 65 th Ann. Meeting of JCA (2006)∝‫ٻ‬ᐂႆⅻ⇂৮С˺ဇ‣•••‒ₜ⁙‡ ‾৴ᏽၨјௐ

P=0.421㪉㪇

P=0.006䊊䊅䊎䊤䉺䉬ᛩਈ⟲䈲ኻᾖ⟲䋨ૐ䉺䊮䊌䉪⾰㘩⟲䋩䉋䉍⢛ㇱ⊹⤏ਛ䈱䊍䊄䊨䉨䉲䊒䊨䊥䊮㊂䈏᦭ᗧ䈮Ⴧട㸢⊹⤏ਛ䈱䉮䊤䊷䉭䊮↥↢⢻䈏ะ਄㪈㪌㪈㪇㪌㪇ኻᾖ⟲फࣱᏽၨὉኄ‫ބ‬၏ࣱዡᐏၐὉἼỸἰἓಮ᧙ራ໒Ὁഫԗ၏ὉʑႁὉỴἘἿὊἲࣱѣᏦᄒ҄ၐὉᏄ฼ὉἉὁễỄỆ᧙ɨલ˩ᎊ҄ἻἕἚỆἡἜἥἻἑἃửᵓᡵ᧓ኺӝ৲ɨᾪᇹᵔᵎ‫ ׅ‬ଐஜ௿᫱Ὁ᫢ኋ‫˟ٻ˟ܖ‬ᵆᵐᵎᵎᵔ࠰ᵇᾬ
11

PSOS

Pt3k
P
Akt

Src
Ras
MAPK᠃ϙ‫܇׆‬ǿȳȑǯឋЎᚐᣞእˊᜓᣞእἡἜἥἻἑἃỉ৴ᏽၨ˺ဇỉἳỽἝἌἲỆ᧙ẴỦჷᙸửࢽỦႸႎỂᘉሥૼဃ৮С˺ဇửᚸ̖䉮䊤䊷䉭䊮 䊊䊅䊎䊤䉺䉬䊕䊒䉼䊄㪎㪇㫄㪾㪆㪢㪾㪉㪌㪇㫄㪾㪆㪢㪾

PᘉሥϋႝኬᏘ‫ف‬഻Ў҄ဃ‫܍‬ᡕឥᘉሥૼဃầỮỊẆᵴᵣᵥᵤίᘉሥϋႝኬᏘ঺ᧈ‫܇׆‬ὸễỄửЎඣẲᘉሥૼဃửᛔ‫ݰ‬ẴỦᵌᵴᵣᵥᵤỉ˺ဇử৮ảủịᘉሥૼဃầ৮СẰủỦᵌ 12ᵫᵿᶒᶐᶇᶅᶃᶊ ᶎᶊᶓᶅඥǷȯ࢟঺ȡǫȋǺȠƱᘉሥૼဃ৮С૾ඥᶂᵿᶗᵋᵏᵑᶂᵿᶗᵋᵕᵡᵓᵕᵠᵪᵍᵔᵨᶂᵿᶗᵎᶂᵿᶗᵓἡἜἥἻἑἃဌஹ ᆆౡᶦᵋἂἽỽὅỉኺӝ৲ɨ᧏‫ڼ‬৲ɨኳʕ ᵫᵿᶒᶐᶇᶅᶃᶊ᣻᣽ᵦᶃᶋᶍᶅᶊᶍᶀᶇᶌኽௐἰἚἼἄἽᵱᵿᶋᶎᶊᶃᵢᶍᶑᶃᵵᵿᶒᶃᶐ
ᵵᵿᶒᶃᶐᶾᵋᶅᶊᶓᶁᵿᶌᶾᵋᶅᶊᶓᶁᵿᶌὼὼᵒᵎᴾᴾᴾᶋᶅᵍᶉᶅᵍᶂᵿᶗ
ᵏᵔᵎᴾᴾᶋᶅᵍᶉᶅᵍᶂᵿᶗᴾᵫᵿᶒᶐᶇᶅᶃᶊชьཋὼ
ᵴᵣᵥᵤᵉᵦᶃᶎᵿᶐᶇᶌ
ᵴᵣᵥᵤᵉᵦᶃᶎᵿᶐᶇᶌ
ᵴᵣᵥᵤᵉᵦᶃᶎᵿᶐᶇᶌ

Hb content (mg/Matrigel)50
ᵴᵣᵥᵤ ᵐᵎᶌᶅᵍᶋᶊᵦᶃᶎᵿᶐᶇᶌ ᵑᵐᵳᵍᶋᶊ*ီễỦᇷӳỊஊॖࠀ(p<0.05)bTSP-1㸣ⴊ▤ᣂ↢ᛥ೙

40
30

a20
10VEGF㸡ⴊ▤ᣂ↢ଦㅴ

aa078ༀ‫ݧ‬ƴǑǔήᎊ҄ưႝᐎƷᘉሥૼဃƕʨᡶ
VEGF+Heparin㱎-glucan䋭
䋭䋫
䋭

䋫
40

䋫
160 (mg/kg)⇵⇰⇹∏⇥⇗ₒ‟⇖∑⇑∙↝ኺӝ৲ɨ↞⅚⁈‷‹‸↚↷↹ᛔ‫↺↻ↄݰ‬ᘉሥૼဃ⇁৮Сↆ↎ႝᐎನᡯƷ‫҄٭‬ƴǑǔǷȯƷ࢟঺Ƿȯʖ᧸ೞᏡࣱ᫢ԼȷǷȯʖ᧸҄ታԼእ஬

13

䌛Biol Pharm Bull. 2009 Feb;32(2):259-63.䌝ᅈϋȢȋǿȸƴǑǔઅӕᚾ᬴

14‫׎‬ϋư්ᡫƠƯƍǔɼƳƖƷƜೞᏡࣱ(ȡȇǣǫȫȞȃǷȥȫȸȠ)૾ඥṼᘮ᬴ᎍᵘᴾᵐᵎᵋᵔᵎˊỉဏ‫ڡ‬ỆợỦᅈϋἴἝἑὊỆợỦʚ᣻Ⴙ౨ඥᵌṼᚸ̖᪮Ⴘᾉ൦Ўᔕ૝᣽ỉย‫ܭ‬ᵌᴾỴὅἃὊἚᛦ௹ửܱ଀ᵌᶂᵿᶗᵋᵏᶂᵿᶗᵋᵕ

ᶂᵿᶗᵏᵒኽௐ
ᵑ৖᠉Ƴ᫢ԼƱƠƯƷƖƷƜ፭ᶂᵿᶗᵐᵖ

ŪೞᏡࣱƴදႸȤȞȖǷǿǱȞǤǿǱ
ǿȢǮǿǱᵈᵈᶎ ᵚᴾᵎᵌᵎᵓᵋᵔઅӕ᧏‫ڼ‬Эᵐᡵ᧓ࢸ൦Ўᔕ૝᣽͌‫҄٭‬ίᶅᵍὮᶆὸ

ᵒᡵ᧓ࢸ

ોծ
ɧ‫٭‬ἡἜἥἻἑἃ፭
ίᵑᵐᵎᶋᶅᵍᶂᵿᶗὸ
ᵎ

ᵐᵎ

ᵒᵎ

ᵔᵎ

ᵖᵎ

ᵃᵏᵎᵎ

ь߻እ஬ử఍െỆኬẦẪẲί࠯‫ר‬ቩࢲ10᷈mὸ,ᶾ-ἂἽỽὅਁЈྙửӼɥ.෇ࣱஜ˳ểẰủỦᶾ-ἂἽỽὅỊ༏൦ϼྸởᣞእϼྸỆợụܾତỆਁЈӧᏡỂẝụỺỿἋ҄ầӧᏡ.
ⷙᩰ㪊㪌㩼એ਄

䇼ේ᧚ᢱฬᮡ⸥଀䇽 䊊䊅䊎䊤䉺䉬㪈㪇㩼એਅ৻⥸↢⩶ᢙ㪊䇼൮ⵝᒻᘒ䇽 1kg䇮100g䋨䉝䊦䊚䊌䉡䉼䋩ᄢ⣺⩶⟲㪊㬍㪈㪇୘㪆㪾એਅ㒶 ᕈ㊀㊄ዻ㪉㪇㫇㫇㫄એਅ䊍 ⚛

㪉㫇㫇㫄એਅ᫢ဇțȳǷȡǸ
᠞λȞȄǿǱ‫׎‬ငȞȄǿǱ

16䌛䊡䊆䉼䉦␠ౝ䊂䊷䉺䌝ṼẨỉẮဃင২ᘐỉૼᙹ᧏ႆ̮߸‫ܖٻ‬ᠾ‫ܖ‬ᢿ ᵋᓏఇỉᏋᆔὉ̬‫܍‬২ᘐỉӕࢽᵋ᩺‫ܖٻޢ‬ᠾ‫ܖ‬ᢿ ᵋ፦ႉјௐỉᚐଢὉૼᙹཋឋỉ੕ኧᵋࣈ޽ᕤᅹ‫ܖٻ‬ᕤ‫ܖ‬ᢿ ᵋ‫ٻ‬ᐂၶႆầỮ৮Сᵋ

ᵠᶇᶍᶑᶁᶇᵌᴾᵠᶇᶍᶒᶃᶁᶆᶌᶍᶊᵌᴾᵠᶇᶍᶁᶆᶃᶋᵌᴾᵕᵏᵆᵕᵇᵊᴾᵏᵖᵎᵒᵋᵏᵖᵎᵔᵆᵐᵎᵎᵕᵇᵠᶇᶍᶊᵌᴾᵮᶆᵿᶐᶋᵌᴾᵠᶓᶊᶊᵌᵑᵑᵆᵖᵇᵏᵑᵓᵓᵋᵏᵑᵓᵗᵆᵐᵎᵏᵎᵇ‫ܖٻ᧵ٻ‬Ҕ‫ܖ‬ᢿ̬ͤ‫ܖ‬ᅹ ᵋ৴ᏽၨὉᘉሥૼဃ᧹ܹ˺ဇỉᚐଢᵋᵠᶇᶍᶊᵌᴾᵮᶆᵿᶐᶋᵌᴾᵠᶓᶊᶊᵌᴾᵑᵐᵆᵐᵇᵘᵐᵓᵗᵋᵔᵑᵆᵐᵎᵎᵗᵇᵌṼஇኳᙌԼỉᚸ̖‫ٻ‬৖Э௿᫱‫ܖ‬ᨈ‫ܖᧉݦ‬ఄ ᵋஇኳᙌԼỉМဇ૾ඥὉἸὊἈὊồỉ੩కᵋᵬᶇᶑᶆᶇᵋᵬᶇᶎᶎᶍᶌᴾᵠᶐᵿᶌᶁᶆᴾᶍᶄᴾᵲᶆᶃᴾᵫᶗᶁᶍᵌᴾᵱᶍᶁᶇᶃᶒᶗᴾᶍᶄᴾᵨᵿᶎᵿᶌᵆᵏᵗᵇᵏᵕᵋᵐᵐᵆᵐᵎᵎᵗᵇ

䇼଻ሽᣇᴺ䇽㜞᷷ᄙḨ䉕ㆱ䈔䇮㘑ㅢ䈚䈱⦟䈇႐ᚲ䈪଻ሽኺӝઅӕỂјௐầ஖ࢳỂẨỦእ஬ỂẆἡἜἥἻἑἃỊ,ἉἱὉἉὁʖ᧸ሁỉ፦ܾ,፦ᎻửႸႎểẲẺ᫢Լእ஬ểẲề෇ဇỂẨỦ.

Ū᭗ኢ᠞λ᫢஬፭
ǢȟǬǵǿǱ(ȢȬȫ)ǢȳǺǿǱǯȭȩȃȑǿǱṼἡἜἥἻἑἃỉૼᙹೞᏡࣱᐯᅈ߻‫↕↚ئ‬ဃင‚‫̓ܭܤ‬ዅⅻӧᏡ‛†ᘓဃႎ↙࿢‫ؾ‬ɦ↖ʴ߻ఎؔ†‒‫ٻ‬ᥛ‫⇁ސ‬ԃ↰ ‫׎‬ငҾ૰እ஬⇁̅ဇ†᳓ ಽŪ᠞λ᫢஬፭(ь߻ဇᡦ)ȞȃǷȥȫȸȠȕǯȭǿǱǭǯȩǲȷǷȭǭǯȩǲǭȌǬǵǿǱŪ‫؏ע‬։‫ࣱڤ‬Ʒ᭗ƍƖƷƜȈȳȓȞǤǿǱȊȩǿǱȖȊȏȪǿǱȠȩǵǭǷȡǸȌȡȪǹǮǿǱŪ᭗ኢ᠞λ᫢஬፭(᣼ဃ/᩼ʴ߻ఎؔ)ȈȪȥȕȝȫȁȸȋʋ߸‫ܖٻ‬ᠾ‫ܖ‬ᢿᵊᴾɶᢿᩓщ ᵋᩓൢἣἽἋХນỆợỦ‫˳ܱ܇‬ႆဃỉᄂᆮᵋἡἜἥἻἑἃỉఎؔỆấẬỦᩓൢἣἽἋҮьỉјௐᵘᇹᵓᵒ‫ׅ‬ଐஜங஬‫˟ٻ˟ܖ‬ᵆᵐᵎᵎᵒᵇἡἜἥἻἑἃỉೞᏡࣱểՠԼ᧏ႆỆếẟềᵘᇹᵓᵓ‫ׅ‬ଐஜங஬‫˟ٻ˟ܖ‬ᵆᵐᵎᵎᵓᵇ‫׎‬ϋ↖ဃငᚑಽ㱎㪄䉫䊦䉦䊮ŪଐࠝႎƴМဇǨȎǭǿǱȊȡǳŪૼƠƍƖƷƜȤȊǮȞȄǿǱǵǵǯȬȒȈȨǿǱȈǭǤȭȒȩǿǱŪ‫؏ע‬։‫ࣱڤ‬Ʒ᭗ƍƖƷƜȏȊǤǰȁȁȁǿǱǢȟǿǱȦȋȁǫȻƱင‫ܖ‬σӷᄂᆮƷӕǓኵǈ⇵⇰⇹∏⇥⇗↗ⅳⅵⅦႉᑥ↝ᑶⅧ⇁ᡲेↄ↊↺↷ⅵ↙࢟ཞ↗ࠎ‫‚ࣱݲ‬᭗ኢज़‛†‒ଐஜ‫׎‬ϋ↖И↰↕ʴ߻ఎؔ↚঺ыↆ„‒᠞λԼⅻ໯ⅳ†‒䇼䊊䊅䊎䊤䉺䉬⵾ຠⷙᩰ䇽ҾஙǷǤǿǱ䌛䊡䊆䉼䉦␠ౝ䊂䊷䉺䌝ˡወႎ↙᫢ኺ᬴⇁ஊↆ↕ⅹ↹„‒ɥࠊˌᨀ↱ஊܹʙᝋ↝‫إ‬ԓ↞↙ⅳ†‒Լᆔႇ᥵↝‫ݣ‬ᝋ↚↱ਦ‫ↆૼ‒„↻ↄܭ‬ⅳⅼ↝ↂ↝ɶ↖↱ဃᮗ᫢Լ↗ↆ↕ᛐჷↄ↻↕ⅳ↺†

࢟ཞⅺ↸⇊∇∞⇞

ŪೞᏡࣱ(᠞λԼ)Ϥᖓٰᒬ᫏ȁȣǬ (ᴎᴢᴶᴡᴉᴝᴘᴑ)᭗ኢज़ŪɟᑍႎᛐჷƷǷȡǸ᫏ǨȪȳǮȏǯȬǤǿǱ ǢǮǿǱȒȩǿǱȖȊǷȡǸǦǹȒȩǿǱ15ೞᏡࣱ᫢Լእ஬ƱƠƯƷȏȊȓȩǿǱ‫ܤ‬μࣱŪǵȫȎǳǷǫǱ᫏ȡǷȞǳȖᩙᑮᲢȞȳȍȳǿǱ᫏Უᓏ࠿ǷǤǿǱἩἻἍἮ፭ᵋᵑŪᲥȚȃȈǵȗȪȏǿǱǷȡǸ͌Ɲǖज़અӕࢸ˳ज़ί҄ታỉụὸἡἜἥἻἑἃ፭ᵎೞᏡࣱǛᚫ൭ƠƨƖƷƜ፭Ū৴ᏽၨ෇ࣱǢǬȪǯǹǿǱȒȡȞȄǿǱย‫ܭ‬અӕኳʕἡἜἥἻἑἃửઅӕẲẺࢸỉኺႝ൦Ўᔕ૝᣽ίᵲᵣᵵᵪ͌ὸỉ‫҄٭‬ἩἻἍἮ፭Ūj-ǰȫǫȳᙌдȏȊȓȩǿǱᶂᵿᶗᵐᵏย‫ܭ‬અӕ᧏‫ڼ‬ᵑᵐᵎᶋᶅᵍᶂᵿᶗᵆᶌᵛᵏᵑᵇ

ᵲᵣᵵᵪίᶅᵍὮᶆὸήᎊ҄᳏᳐ƕǷȯႆဃƷɼᙲ‫׆‬ᶂᵿᶗᵔṞૼᙹೞᏡࣱ੕ኧỉᚸ̖ኒửấਤẼỉᄂᆮܴཎỆ፦ܾὉἒỶỺἕἚ᧙ᡲᶃᶒᶁᵌṟஇኳᙌԼỉь߻২ᘐửਤếᄂᆮܴ̊ᵇἜἠ҄ϼྸỉ২ᘐᶃᶒᶁᵌᵋ ἸἝἓỽỉʻࢸỉ᧏ႆἅὅἍἩἚ ᵋ17ἡἜἥἻἑἃử፦ܾὉ፦Ꮋእ஬ồẒẨỉẮỂ࣎ờ˳ờỿἾỶỆễỨạὲẓẨỉẮỂ࣎ờ˳ờỿἾỶỆễỨạὲẓ18ࣂ᩺ᎮஊᩊƏƝƟƍǇƠƨŵↃឋբ∝᝻૰↝Ↄᛪ൭„‒င‫ܖ‬σӷ↝Ↄ੩క ↚᧙ↆ↭ↆ↕↞∌⇱⇧⇑ఇࡸ˟ᅈ ဃ෇ͤࡍʙಅᢿ↭↖ⅹᫍⅳᐲↆ↭ↈ⅛⁆‷‾‬•‣․•‟‧…‣‟‪ •‒‒‒‒‒‒‒‸″⁊‬•‣․•‟…‪․‟‪ •ဃᮗԼ↞⇊∙⇥∞⇳⇩⇮↚↷↺ᡫ̮ᝤ٥↝˂„ɦᚡ↝ⅹࡃ↖↱ӕ↹ৢ→↕ⅹ↹↭ↈ†19