Exhibit 21
The following is a list of subsidiaries of the Company as of December 31, 2019 omitting somesubsidiaries which, considered in the aggregate, would not constitute a significant subsidiary.
Company Name
Agouron Pharmaceuticals, LLC
AH Robins LLC
AHP Holdings B.V.
AHP Manufacturing B.V.
Alpharma Pharmaceuticals LLC
Alpharma Specialty Pharma LLC
American Food Industries LLC
Anacor Pharmaceuticals, Inc.
Array BioPharma Inc.
Array BioPharma Limited
Array BioPharma Ltd.
Bamboo Therapeutics, Inc.
BINESA 2002, S.L.
Bioren, LLC
Blue Whale Re Ltd.
C.P. Pharmaceuticals International C.V.
CICL Corporation
COC I Corporation
Coley Pharmaceutical GmbH
Coley Pharmaceutical Group, Inc.
Continental Pharma, Inc.
Covx Technologies Ireland Limited
Cyanamid de Argentina S.A.
Cyanamid de Colombia, S.A.
Distribuidora Mercantil Centro Americana, S.A.
Encysive Pharmaceuticals Inc.
Excaliard Pharmaceuticals, Inc.
Farminova Produtos Farmaceuticos de Inovacao, Lda.
Farmogene Productos Farmaceuticos Lda
FoldRx Pharmaceuticals, Inc.
Fort Dodge Manufatura Ltda.
G. D. Searle & Co. Limited
G. D. Searle International Capital LLC
G. D. Searle LLC
Genetics Institute, LLC
GenTrac, Inc.
GI Europe, Inc.
GI Japan, Inc.
Greenstone LLC

Where Incorporated or Organized
California
Delaware
Netherlands
Netherlands
Delaware
Delaware
Delaware
Delaware
Delaware
IrelandUnited Kingdom
DelawareSpain
DelawareVermont
Netherlands
Delaware
DelawareGermany
Delaware
Delaware
Ireland
Delaware
Delaware
Delaware
Delaware
Delaware
PortugalPortugal
DelawareBrazilUnited Kingdom
Delaware
Delaware
Delaware
Wisconsin
Delaware
Delaware
DelawareHospira Adelaide Pty Ltd

AustraliaHospira Australia Pty Ltd
Hospira Benelux BVBA
Hospira Enterprises B.V.
Hospira France SAS
Hospira Holdings (S.A.) Pty Ltd
Hospira Invicta, S.A.
Hospira Ireland Holdings Unlimited Company
Hospira Limited
Hospira Malaysia Sdn Bhd
Hospira Nordic AB
Hospira Philippines, Inc.
Hospira Pte. Ltd.
Hospira Pty Limited
Hospira Puerto Rico, LLC
Hospira Singapore Pte Ltd
Hospira UK Limited
Hospira Worldwide, LLC
Hospira Zagreb d.o.o.
Hospira, Inc.
Ignite Immunotherapy, Inc.
Industrial Santa Agape, S.A.
InnoPharma, Inc.
International Affiliated Corporation LLC
IP Pharmaceuticals India Private Limited
JMI-Daniels Pharmaceuticals, Inc.
John Wyeth & Brother Limited
Kiinteistö oy Espoon Pellavaniementie 14
King Pharmaceuticals Holdings LLC
King Pharmaceuticals LLC
King Pharmaceuticals Research and Development, LLC
Korea Pharma Holding Company Limited
Laboratoires Pfizer, S.A.
Laboratorios Parke Davis, S.L.
Laboratorios Pfizer Ltda.
Laboratórios Pfizer, Lda.
Laboratorios Wyeth LLC
Laboratorios Wyeth S.A.
Mayne Pharma IP Holdings (Euro) Pty Ltd
Medivation Field Solutions LLC
Medivation LLC
Medivation Neurology LLC
Medivation Prostate Therapeutics LLC
Medivation Services LLC
Medivation Technologies LLC
Meridian Medical Technologies Limited

Australia
Belgium
Netherlands
FranceAustralia
Spain
IrelandHong Kong
Malaysia
SwedenPhilippines
Singapore
AustraliaDelaware
Singapore
United Kingdom
DelawareCroatia
Delaware
DelawareGuatemalaDelaware
Delaware
India
FloridaUnited Kingdom
Finland
Delaware
Delaware
DelawareHong Kong
MoroccoSpain
BrazilPortugalPennsylvania
Venezuela
Australia
Delaware
Delaware
Delaware
Delaware
Delaware
Delaware
United Kingdom

Meridian Medical Technologies, Inc.
Monarch Pharmaceuticals, LLC
MTG Divestitures LLC
Neusentis Limited
PAH USA IN8 LLC
Parke Davis Limited
Parke Davis Productos Farmaceuticos Lda
Parke, Davis & Company LLC
Parkedale Pharmaceuticals, Inc.
PBG Puerto Rico LLC
PCH SpinCo B.V.
P-D Co., LLC
Peak Enterprises LLC
PEMB OFG Spain Holding, S.L.
PF Asia Manufacturing B.V.
PF Consumer Healthcare Austria GmbHPF Consumer Healthcare Holdings LLC
PF Consumer Healthcare Holdings US Inc.
PF Consumer Healthcare Poland sp. z.o.o.
PF Consumer Taiwan LLC
PF Czech Republic Holdings B.V.
PF Finland Holdings B.V.
PF OFG Ireland 1 B.V.
PF OFG Ireland 2 B.V.
PF OFG Mexico B.V.
PF OFG Philippines B.V.
PF OFG Philippines, Inc.
PF OFG Sdn. Bhd.
PF OFG South Korea 1 B.V.
PF OFG South Korea 2 B.V.
PF OFG Spain B.V.
PF PR Holdings C.V.
PF PRISM C.V.
PF PRISM Holdings B.V.
PF PRISM IMB B.V.
PF Prism S.á.r.l.
PFE Holdings G.K.
PFE Pfizer Holdings 1 LLC
PFE PHAC Holdings 1 LLC
PFE Wyeth Holdings LLC
PFE Wyeth-Ayerst (Asia) LLC
Pfizer
Pfizer (China) Research and Development Co. Ltd.
Pfizer (Malaysia) Sdn Bhd
Pfizer (Perth) Pty Ltd
Pfizer (Thailand) Limited

DelawareTennessee
Delaware
United Kingdom
DelawareHong Kong
Portugal
Michigan
Michigan
Puerto Rico
Netherlands
Delaware
Delaware
Spain
Netherlands
Austria
Delaware
DelawarePolandDelaware
Netherlands
Netherlands
Netherlands
Netherlands
NetherlandsNetherlands
Philippines
Malaysia
Netherlands
Netherlands
Netherlands
Netherlands
Netherlands
Netherlands
Netherlands
Luxembourg
Japan
Delaware
Delaware
Delaware
Delaware
FrancePeople's Republic ofChina
Malaysia
AustraliaThailandPfizer (Wuhan) Research and Development Co. Ltd.
Pfizer AB
Pfizer Advanced Pharmaceutical Company Limited
Pfizer Africa & Middle East for Pharmaceuticals, Veterinarian Products &Chemicals S.A.E.
Pfizer Afrique de L'Ouest
Pfizer AG
Pfizer Anti-Infectives AB
Pfizer ApS
Pfizer AS
Pfizer Asia Manufacturing Pte. Ltd.
Pfizer Asia Pacific Pte Ltd.
Pfizer Australia Holdings B.V.
Pfizer Australia Holdings Pty Limited
Pfizer Australia Investments Pty Ltd
Pfizer Australia Pty Ltd
Pfizer B.V.
Pfizer BH D.o.o.
Pfizer Biofarmacêutica, Sociedade Unipessoal Lda
Pfizer Biologics (Hangzhou) Co. Ltd
Pfizer Biologics Ireland Holdings Limited
Pfizer Biopharma Egypt Import LLC
Pfizer Biopharmaceuticals Egypt LLC
Pfizer Biotech Corporation
Pfizer Bolivia S.A.
Pfizer Canada ULC / Pfizer Canada SRI
Pfizer CentreSource Asia Pacific Pte. Ltd.
Pfizer Chile S.A.
Pfizer Cia. Ltda.
Pfizer Colombia Spinco I LLC
Pfizer Commercial Holdings TRAE Kft.
Pfizer Commercial TRAE Trading Kft.
Pfizer Consumer Healthcare
Pfizer Corporation Austria Gesellschaft m.b.H.
Pfizer Corporation Hong Kong Limited
Pfizer Corporation S. de R.L.
Pfizer Croatia d.o.o.
Pfizer Deutschland GmbH
Pfizer Development B.V.
Pfizer Development LLC
Pfizer Development LP
Pfizer Development Services (UK) Limited
Pfizer Dominicana, S.R.L
Pfizer East India B.V.
Pfizer Eastern Investments B.V.

People's Republic ofChina
SwedenTaiwanEgypt
Senegal
Switzerland
SwedenDenmark
NorwaySingapore
Singapore
Netherlands
Australia
AustraliaAustralia
Netherlands
Bosnia andHerzegovina
Portugal
People's Republic ofChina
Ireland
Egypt
Egypt
TaiwanBolivia
CanadaSingapore
Chile
EcuadorPennsylvania
Hungary
Hungary
United Kingdom
Austria
Hong Kong
PanamaCroatia
Germany
Netherlands
Delaware
United Kingdom
United Kingdom
Dominican RepublicNetherlands
Netherlands

Pfizer Egypt S.A.E.
Pfizer Enterprise Holdings B.V.
Pfizer Enterprises LLC
Pfizer Enterprises SARL
Pfizer ESP Pty. Ltd.
Pfizer Established Medicine Italy S.r.l.
Pfizer Europe Finance B.V.
Pfizer Export B.V.
Pfizer Export Company
Pfizer Export Holding Company B.V
Pfizer Finance Share Service (Dalian) Co., Ltd.
Pfizer Financial Services
Pfizer France International Investments
Pfizer Free Zone Panama, S. de R.L.
Pfizer GEP, S.L.
Pfizer Global Holdings B.V.
Pfizer Global Supply Japan Inc.
Pfizer Global Trading
Pfizer Group Luxembourg SARL
Pfizer Gulf FZ-LLC
Pfizer H.C.P. Corporation
Pfizer Health AB
Pfizer Health Solutions Inc.
Pfizer Healthcare India Private Limited
Pfizer Healthcare Ireland
Pfizer Hellas, A.E.
Pfizer Himalaya Holdings Coöperatief U.A.
Pfizer Holding France
Pfizer Holding Ventures
Pfizer Holdings Corporation
Pfizer Holdings Europe Unlimited Company
Pfizer Holdings G.K.
Pfizer Holdings International Corporation
Pfizer Holdings International Luxembourg (PHIL) SARL
Pfizer Hungary Holdings TRAE Kft.
Pfizer Ilaclari Limited Sirketi
Pfizer Innovations AB
Pfizer Innovations LLC
Pfizer Innovative Supply Point International BVBA
Pfizer International LLC
Pfizer International Markets B.V.
Pfizer International Operations
Pfizer International S. de R.L.
Pfizer International Trading (Shanghai) Limited
Pfizer Investment Capital Unlimited Company

Egypt
Netherlands
Delaware
Luxembourg
Australia
Italy
Netherlands
Netherlands
IrelandNetherlands
People's Republic of
China
Belgium
FrancePanamaSpain
Netherlands
JapanIreland
Luxembourg
United Arab Emirates
New York
SwedenDelaware
India
Ireland
GreeceNetherlands
FranceIreland
Delaware
IrelandJapan
Delaware
Luxembourg
Hungary
TurkeySwedenRussiaBelgium
New York
Netherlands
FrancePanamaPeople's Republic of
China
IrelandPfizer Investment Co. Ltd.

People's Republic of
China
Pfizer Investment Holdings S.a.r.l.
Luxembourg
Pfizer Ireland Investments Limited
IrelandPfizer Ireland PFE Holding 1 LLC
DelawarePfizer Ireland PFE Holding 2 LLC
DelawarePfizer Ireland Pharmaceuticals
IrelandPfizer Ireland Ventures Unlimited Company
IrelandPfizer Italia S.r.l.
Italy
Pfizer Italy Group Holding S.r.l.
Italy
Pfizer Japan Inc.
Japan
Pfizer Laboratories (Pty) Limited
South Africa
Pfizer Laboratories Limited
Kenya
Pfizer Leasing Ireland Limited
IrelandPfizer Leasing UK Limited
United Kingdom
Pfizer Limited
India
Pfizer Limited
TaiwanPfizer Limited
United Kingdom
Pfizer LLC
RussiaPfizer Luxco Holdings SARL
Luxembourg
Pfizer Luxembourg Global Holdings S.à r.l.
Luxembourg
Pfizer Luxembourg SARL
Luxembourg
Pfizer Manufacturing Austria G.m.b.H.
Austria
Pfizer Manufacturing Belgium N.V.
Belgium
Pfizer Manufacturing Deutschland GmbHGermany
Pfizer Manufacturing Deutschland Grundbesitz GmbH & Co. KG
Germany
Pfizer Manufacturing Holdings LLC
DelawarePfizer Manufacturing Ireland Unlimited CompanyIreland
Pfizer Manufacturing LLC
DelawarePfizer Manufacturing Services
IrelandPfizer MAP Holding, Inc.
DelawarePfizer Medical Technology Group (Belgium) N.V.
Belgium
Pfizer Medicamentos Genericos e Participacoes Ltda.
BrazilPfizer Mexico Holding 2 B.V.
Netherlands
Pfizer Mexico Holding B.V.
Netherlands
Pfizer Mexico, S.A. de C.V.
MexicoPfizer Middle East for Pharmaceuticals, Animal Health and Chemicals S.A.E. Egypt
Pfizer New Zealand Limited
New ZealandPfizer Norge AS
NorwayPfizer North America Services LLC
DelawarePfizer OFG Germany GmbHGermany
Pfizer OTC B.V.
Netherlands
Pfizer Overseas LLC
DelawarePfizer Oy
FinlandPfizer Pakistan Limited
Pakistan
Pfizer Parke Davis (Thailand) Ltd.
Thailand
Pfizer Parke Davis Sdn. Bhd.
MalaysiaPfizer PFE ApS
Pfizer PFE AsiaPac Holding B.V.
Pfizer PFE Australia Holding B.V.
Pfizer PFE Australia Pty Ltd
Pfizer PFE Belgium SPRL
Pfizer PFE CIA. Ltda.
Pfizer PFE Colombia Holding LLC
Pfizer PFE Croatia Holding B.V.
Pfizer PFE Eastern Investments B.V.
Pfizer PFE Finland Oy
Pfizer PFE France
Pfizer PFE Global Holdings B.V.
Pfizer PFE İlaçları Anonim Şirketi
Pfizer PFE Ireland Pharmaceuticals Holding 1 B.V.
Pfizer PFE Limited
Pfizer PFE Norway Holding S.à r.l.
Pfizer PFE Peru S.R.L.
Pfizer PFE Pharmaceuticals Israel Holding LLC
Pfizer PFE Pharmaceuticals Israel Ltd.
Pfizer PFE PILSA Holdco S.à r.l.
Pfizer PFE Private Limited
Pfizer PFE Service Company Holding B.V.
Pfizer PFE Singapore Holding B.V.
Pfizer PFE Singapore Pte. Ltd.
Pfizer PFE Spain B.V.
Pfizer PFE Spain Holding, S.L.
Pfizer PFE Switzerland GmbH
Pfizer PFE Turkey Holding 1 B.V.
Pfizer PFE Turkey Holding 2 B.V.
Pfizer PFE UK Holding 4 LP
Pfizer PFE US Holdings 4 LLC
Pfizer PFE US Holdings 5 LLC
Pfizer PFE, spol. s r.o.
Pfizer Pharm Algerie
Pfizer Pharma GmbH
Pfizer Pharma PFE GmbH
Pfizer Pharmaceutical (Wuxi) Co., Ltd.

Denmark
Netherlands
Netherlands
Australia
Belgium
Ecuador
Delaware
Netherlands
Netherlands
FinlandFranceNetherlands
TurkeyNetherlands
TaiwanLuxembourg
Peru
Delaware
IsraelLuxembourg
Singapore
Netherlands
Netherlands
Singapore
Netherlands
Spain
Switzerland
Netherlands
Netherlands
United Kingdom
Delaware
DelawareCzech Republic
Algeria
Germany
Germany
People's Republic ofChina
Pfizer Pharmaceutical Trading Limited Liability Company (a/k/a Pfizer Kft. or Hungary
Pfizer LLC)
Pfizer Pharmaceuticals Global B.V.
Netherlands
Pfizer Pharmaceuticals Israel Ltd.
IsraelPfizer Pharmaceuticals K.K.
JapanPfizer Pharmaceuticals Korea Limited
Korea
Pfizer Pharmaceuticals LLC
DelawarePfizer Pharmaceuticals Ltd.
People's Republic ofChina

Pfizer Pharmaceuticals Science and Technology Co., Ltd.
Pfizer Pharmaceuticals Tunisie Sarl
Pfizer Pigments Inc.
Pfizer Polska Sp. z.o.o.
Pfizer Private Limited
Pfizer Production LLC
Pfizer Products Inc.
Pfizer Products India Private Limited
Pfizer R&D Holding B.V.
Pfizer R&D Japan G.K.
Pfizer R&D UK Limited
Pfizer Research (NC), Inc.
Pfizer Romania SRL
Pfizer S.A.
Pfizer S.A. (Belgium)
Pfizer S.A.S.
Pfizer S.G.P.S. Lda.
Pfizer S.r.l.
Pfizer S.R.L.
Pfizer Saidal Manufacturing
Pfizer Saudi Limited
Pfizer Service Company BVBA
Pfizer Service Company Ireland Unlimited Company
Pfizer Services 1
Pfizer Services LLC
Pfizer Shared Services Unlimited Company
Pfizer Shareholdings Intermediate SARL
Pfizer Singapore Holding Pte. Ltd.
Pfizer Specialties Limited
Pfizer SRB d.o.o.
Pfizer Strategic Investment Holdings LLC
Pfizer Trading Polska sp.z.o.o.
Pfizer TRAE Holdings Kft.
Pfizer Transactions Ireland Unlimited Company
Pfizer Transactions LLC
Pfizer Tunisie SA
Pfizer UPJ G.K.
Pfizer Upjohn Hong Kong Limited
Pfizer Upjohn Korea Limited
Pfizer Upjohn Management Co., Ltd.
Pfizer Upjohn Medical Trading Co., Ltd.
Pfizer Vaccines LLC
Pfizer Venezuela, S.A.
Pfizer Venture Investments LLC
Pfizer Ventures (US) LLC

People's Republic ofChina
Tunisia
DelawarePolandSingapore
DelawareConnecticut
India
Netherlands
Japan
United Kingdom
DelawareRomania
Peru
Belgium
Colombia
Portugal
Italy
Argentina
Algeria
Saudi Arabia
Belgium
IrelandFranceDelaware
Ireland
Luxembourg
Singapore
Nigeria
SerbiaDelawarePolandHungaryIreland
DelawareTunisia
JapanHong KongKorea
People's Republic ofChina
People's Republic ofChina
DelawareVenezuela
Delaware
DelawarePfizer Ventures LLC
Pfizer Worldwide Services Unlimited Company
Pfizer Zona Franca, S.A.
Pfizer, Inc.
Pfizer, S.A.
Pfizer, S.A. de C.V.
Pfizer, S.L.
Pfizer, spol. s r.o.
Pharmacia & Upjohn Company LLC
Pharmacia & Upjohn LLC
Pharmacia & Upjohn, S.A. de C.V.
Pharmacia Brasil Ltda.
Pharmacia Hepar LLC
Pharmacia Holding AB
Pharmacia Inter-American LLC
Pharmacia International B.V.
Pharmacia Limited
Pharmacia LLC
Pharmacia Nostrum, S.A.
PHIVCO Corp.
PHIVCO Holdco S.à r.l.
PHIVCO Luxembourg S.à r.l.
PIMB OFG Spain Holding, S.L.
PRISM Holdings B.V.
PT. Pfizer Indonesia
PT. Pfizer Parke Davis
Purepac Pharmaceutical Holdings LLC
Renrall LLC
Rinat Neuroscience Corp.
Roerig Produtos Farmaceuticos, Lda.
Roerig S.A.
Searle Laboratorios, Lda.
Servicios P&U, S. de R.L. de C.V.
Shiley LLC
Sinergis Farma-Produtos Farmaceuticos, Lda.
Solinor LLC
Sugen LLC
Tabor LLC
The Pfizer Incubator LLC
Therachon
Therachon Holding GmbH
Upjohn (Thailand) Limited
Upjohn Australia Pty Ltd.
Upjohn Belgium B.V.
Upjohn Canada ULC
Upjohn Europe Holdings B.V.
Upjohn Export B.V.

Delaware
Ireland
Costa Rica
Philippines
Costa Rica
MexicoSpain
Czech Republic
Delaware
Delaware
MexicoBrazilDelawareSwedenPennsylvania
Netherlands
United Kingdom
DelawareSpain
Delaware
Luxembourg
Luxembourg
Spain
Netherlands
Indonesia
Indonesia
DelawareWyoming
Delaware
Portugal
Chile
PortugalMexicoCalifornia
Portugal
Delaware
Delaware
Delaware
Delaware
FranceSwitzerland
ThailandAustralia
Netherlands
CanadaNetherlands
Netherlands

Upjohn Global Holdings B.V.
Upjohn Group Holdings B.V.
Upjohn Hellas Pharmaceutical Limited Liability Company
Upjohn Inc.
Upjohn Intermediate Holdings B.V.
Upjohn International Holdings B.V.
Upjohn Laboratorios Lda.
Upjohn Manufacturing Ireland Unlimited Company
Upjohn Middle East FZ-LLC
Upjohn Netherlands B.V.
Upjohn New Zealand ULC
Upjohn Pharma Mexico S. de R.L. de C.V.
Upjohn Pharmaceuticals Inc.
Upjohn PR Holdings C.V.
Upjohn PRISM B.V.
Upjohn South Africa
Upjohn UK 2 Ltd.
Upjohn UK Limited
Upjohn US 1 LLC
Upjohn US 2 LLC
Upjohn US Employment Inc.
Upjohn US Holdings Inc.
Upjohn Worldwide Holdings Inc.
Utah Acquisition Holdco Inc.
Utah Acquisition Sub Inc.
Vicuron Holdings LLC
Vinci Farma, S.A.
Warner Lambert del Uruguay S.A.
Warner Lambert Ilac Sanayi ve Ticaret Limited Sirketi
Warner-Lambert (Thailand) Limited
Warner-Lambert Company AG
Warner-Lambert Company LLC
Whitehall Laboratories Inc.
W-L LLC
Wyeth (Thailand) Ltd.
Wyeth AB
Wyeth Ayerst Inc.
Wyeth Ayerst S.à r.l.
Wyeth Europa Limited
Wyeth Farma, S.A.
Wyeth Holdings LLC
Wyeth Industria Farmaceutica Ltda.
Wyeth KFT.
Wyeth Lederle S.r.l.
Wyeth Lederle Vaccines S.A.
Wyeth LLC
Wyeth Pakistan Limited

Netherlands
Netherlands
GreeceDelaware
Netherlands
Netherlands
PortugalIreland
United Arab Emirates
Netherlands
New Zealand
MexicoDelaware
Netherlands
Netherlands
South Africa
United Kingdom
United Kingdom
Delaware
Delaware
Delaware
Delaware
Delaware
Delaware
Delaware
DelawareSpain
Uruguay
TurkeyThailand
Switzerland
Delaware
Delaware
DelawareThailand
SwedenDelaware
Luxembourg
United Kingdom
Spain
Maine
BrazilHungary
Italy
Belgium
Delaware
PakistanWyeth Pharmaceuticals FZ-LLC
Wyeth Pharmaceuticals India Private Limited
Wyeth Pharmaceuticals LLC
Wyeth Subsidiary Illinois Corporation
Wyeth Whitehall Export GmbH
Wyeth-Ayerst (Asia) LLC
Wyeth-Ayerst International LLC
Wyeth-Ayerst Promotions Limited

United Arab Emirates
India
DelawareIllinois
Austria
Delaware
Delaware
DelawareYarra Therapeutics, LLC

Delaware