ู⣬㸲Ꮫ ఩ ㄽ ᩥ ࡢ せ ᪨  ㄽᩥ㢟┠   Studies on the molecular mechanisms that regulate lifespan in budding yeast         (ฟⱆ㓝ẕࡢᑑ࿨ࢆไᚚࡍࡿศᏊᶵᵓࡢ◊✲)                   ᗈᓥ኱Ꮫ኱Ꮫ㝔⤫ྜ⏕࿨⛉Ꮫ◊✲⛉                      ⏕≀ᕤᏛࣉࣟࢢ࣒ࣛ                   Ꮫ⏕␒ྕ D203324
                   Ặ  ྡ ┈ᮧ ᫭ྖᗎㄽ ⪁໬࣭ᑑ࿨ไᚚᶵᵓࡢゎ᫂ࡣࠊࣄࢺࡢ೺ᗣᑑ࿨࣭ᑑ࿨ᘏ㛗ࢆ⌮ゎࡍࡿࡓࡵࡢ㔜せ࡞ㄢ㢟ࡢ୍ࡘ࡛࠶ࡿࠋ⪁໬࣭ᑑ࿨◊✲ࡣࠊ⏕≀Ꮫⓗ⪁໬ࡢ⌮ゎࡔࡅ࡛࡞ࡃࠊ⪁໬࡟క࠺ࡀࢇࡸᚰ⮚⑓ࠊ⚄⤒⑌ᝈ࡞࡝ࡢྛ✀⑌ᝈࡢⓎ⑕ᶵᵓࡸ἞⒪࡬ࡢᛂ⏝ࡀᮇᚅࡉࢀࡿࠋࡇࢀࡲ࡛࡟ࠊ㓝ẕࠊ⥺⹸ࠊࣁ࢚ࠊ࣐࢘ࢫ࡞࡝ࣄࢺࡢࣔࢹࣝ࡜࡞ࡿ⏕≀ࢆ⏝࠸࡚ࠊᑑ࿨ไᚚ࡟㛵ࢃࡿඹ㏻ࡢศᏊࡸࡑࡢ࣓࢝ࢽࢬ࣒ࡀ᫂ࡽ࠿࡟࡞ࡗ࡚ࡁࡓࠋ౛࠼ࡤࠊ࣮࢝ࣟࣜไ㝈ࡸ࣓ࢳ࢜ࢽࣥไ㝈(MetR)࡞࡝ࡢ㣗஦ไ㝈ࠊmTORC1(mechanistic Target ofrapamycin complexϨ)⤒㊰ࡢ୙άᛶ໬ࠊAMPK(AMP άᛶ໬ࣉࣟࢸ࢖ࣥ࢟ࢼ࣮ࢮ)ࡢάᛶ໬ࡣከࡃࡢ
ࣔࢹࣝ⏕≀࡛ᑑ࿨ᘏ㛗ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋ࠿ࡋࠊࡑࡢヲ⣽࡞ศᏊ࣓࢝ࢽࢬ࣒ࡸࠊᑑ࿨࡜ࢩࢢࢼࣝఏ㐩⤒㊰࡜ࡢ㛵ಀࡣᮍࡔ୙᫂࡞Ⅼࡶከ࠸ࠋ ⴭ⪅ࡢᡤᒓ◊✲ᐊ࡛ࡣࡇࢀࡲ࡛࡟ࠊฟⱆ㓝ẕࡢ࢝ࣝࢩ࣒࢘࢖࢜ࣥ(Ca2+)౫Ꮡᛶࣉࣟࢸ࢖ࣥ࣍ࢫࣇ࢓
ࢱ࣮ࢮ࡛࠶ࡿ࢝ࣝࢩࢽ࣮ࣗࣜࣥ(CN)ࢆୡ⏺࡟ඛ㥑ࡅ࡚ⓎぢࡋࠊCa2+ࢩࢢࢼࣝࡀ CN ࡜ Mpk1(MAP ࢟ࢼ࣮ࢮ)ࢆάᛶ໬ࡋࠊSwe1 ࢟ࢼ࣮ࢮ(⣽⬊࿘ᮇࡢ㈇ࡢㄪ⠇ᅉᏊ)ࡢάᛶㄪ⠇ࢆ௓ࡋ࡚ࠊ⣽⬊࿘ᮇ㐍⾜ࢆ㜼ᐖࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋ࡚ࡁࡓࠋCa2+ࢩࢢࢼࣝ࡟ࡼࡿ⣽⬊࿘ᮇࡢࡉࡽ࡞ࡿไᚚᶵᵓࢆゎ᫂ࡍࡿࡓࡵࠊ
Ca2+ ࢩࢢࢼࣝ࡟ᛂ⟅࡛ࡁ࡞ࡃ࡞ࡗࡓኚ␗ᰴࡢྲྀᚓࡀ⾜ࢃࢀࡓࠋࡑࡢ⤖ᯝࠊ scz1~14 ኚ␗ᰴ࠾ࡼࡧsgh1~6 ኚ␗ᰴࡀྲྀᚓࡉࢀࡓࠋ⯆࿡῝࠸ࡇ࡜࡟ࠊscz14 ࡣᑑ࿨࡜ࡢ㛵㐃ࡀ῝࠸㑇ఏᏊࢧ࢖ࣞࣥࢩࣥࢢ࡟㛵ࢃࡿ SIR3 ࡟࠾ࡅࡿኚ␗࡛࠶ࡗࡓࠋࡇࢀ࡟ࡼࡾࠊCa2+ࢩࢢࢼࣝࡀ᪂ࡓ࡟ᑑ࿨ไᚚ࡟ࡶ㛵୚ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡑࡇ࡛ࠊᮏ◊✲࡛ࡣᑑ࿨ไᚚ࡬ࡢ㛵୚ࡀண᝿ࡉࢀࡿ scz7 ኚ␗ᰴ࠾ࡼࡧ sgh5 ኚ␗ᰴࢆ⏝࠸ࡓゎᯒࡢ㛵㐃࠿ࡽࠊฟⱆ㓝ẕࡢ᪂つᑑ࿨ไᚚ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ➨୍❶࡛ࡣࠊࢫࢺࣞࢫᛂ⟅ᛶࢩࢢࢼࣝ⤒㊰࡜ᑑ࿨ไᚚ࡜ࡢ㛵ಀ࡟ࡘ࠸࡚ゎᯒࡋࡓࠋHigh Osmolarity
Glycerol(HOG)⤒㊰ࡣࠊ㧗ᾐ㏱ᅽ࡟ᛂ⟅ࡋάᛶ໬ࡉࢀࡿࢫࢺࣞࢫᛂ⟅ᛶ MAPK ⤒㊰࡛࠶ࡿࠋࡑࡢୗὶ
ᅉᏊ Hog1 ࡣ㧗ᾐ㏱ᅽࡸ㓟໬ࢫࢺࣞࢫࠊ⣽⬊࿘ᮇ㐍⾜࡞࡝ᵝࠎ࡞⏕Ꮡᛂ⟅ࢆไᚚࡍࡿࠋⴭ⪅ࡢᡤᒓ◊✲ᐊ࡛ࡣࠊHog1 ࡢ◚ቯᰴࡀ♧ࡍ Ca2+ឤཷᛶ࠾ࡼࡧ㧗ᾐ㏱ᅽឤཷᛶࡢᢚᅽᅉᏊ࡜ࡋ࡚ࠊsko1-18/sgh5ኚ␗ࢆྲྀᚓࡋࡓࠋSko1 ࡣ Tup1-Cyc8 ࡜」ྜయࢆᙧᡂࡋ㧗ᾐ㏱ᅽࡸ㓟໬ࢫࢺࣞࢫㄏᑟᛶ㑇ఏᏊࡢ㌿෗ࢆ㜼ᐖࡍࡿࡀࠊࢫࢺࣞࢫᛂ⟅᫬࡟ࡣ Sko1-Tup1-Cyc8 」ྜయࡀ Hog1 ࡟ࡼࡗ࡚ࣜࣥ㓟໬ࡉࢀࡿࡇ࡜࡛
㌿෗ࢆάᛶ໬ࡍࡿࠋࡇࢀࡲ࡛࡟ࠊSko1 ࡢኚ␗యࡣ㓟໬ࢫࢺࣞࢫ⪏ᛶࢆ♧ࡋࠊhog1'◚ቯᰴࡀ♧ࡍ㓟໬ࢫࢺࣞࢫឤཷᛶࡣ Sko1 ࡢᶵ⬟Ḟᦆ࡟ࡼࡗ࡚ᢚᅽࡉࢀࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋࡲࡓࠊhog1'◚ቯᰴࡣ⤒᫬ᑑ࿨(ศ⿣೵Ṇ⣽⬊ࡢ⏕Ꮡᮇ㛫)࡟࠾࠸࡚▷࿨ࢆ♧ࡍࡇ࡜࠿ࡽࠊ⣽⬊ࡢ⏕Ꮡ࡟ࡣ HOG ⤒㊰ࡀ㔜せ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡑࡇ࡛ᮏ◊✲࡛ࡣࠊhog1'◚ቯᰴࡢࢫࢺࣞࢫឤཷᛶࢆᢚᅽࡍࡿᅉᏊ࡜ࡋ࡚
ྲྀᚓࡉࢀࡓ Sko1 ࡢᑑ࿨ไᚚ࡟࠾ࡅࡿᙺ๭ࢆゎᯒࡋࡓࠋ ➨஧❶࡛ࡣࠊᰤ㣴࣭௦ㅰࢩࢢࢼࣝࡀ㛵ࢃࡿᑑ࿨ไᚚᶵᵓ࡟ࡘ࠸࡚ゎᯒࢆ⾜ࡗࡓࠋsah1/scz7 ኚ␗ࡣ S࢔ࢹࣀࢩࣝ࣍ࣔࢩࢫࢸ࢖ࣥ(SAH)Ỉゎ㓝⣲ SAH1 ࡟࠾ࡅࡿኚ␗࡛࠶ࡾࠊࡇࢀࡲ࡛࡟ sah1 ኚ␗ᰴࡣቑṪ㐜ᘏ࡜⤒᫬ᑑ࿨࠾ࡼࡧ」〇ᑑ࿨(୍ࡘࡢẕ⣽⬊ࡢศ⿣ᅇᩘ)࡟࠾࠸࡚▷࿨ࢆ♧ࡍࡇ࡜ࢆぢฟࡋࡓࠋࡇࢀ࡟ࡼࡾࠊ࣓ࢳ࢜ࢽࣥ௦ㅰ࡜ᑑ࿨࡜ࡢ㛵㐃ࡀ♧၀ࡉࢀࡓࠋࡑࡇ࡛ࠊ᪂つᑑ࿨ไᚚᅉᏊࡢྲྀᚓࡢࡓࡵࠊsah1 ኚ␗ᰴࡢቑṪ㐜ᘏࢆᢚᅽࡍࡿࢫࢡ࣮ࣜࢽࣥࢢࡀ⾜ࢃࢀࡓࠋࡑࡢ⤖ᯝࠊ⏕యࡢ୺せ࡞࣓ࢳࣝᇶ౪୚
య S-࢔ࢹࣀࢩ࣓ࣝࢳ࢜ࢽࣥ(SAM)ࢆ㧗⵳✚ࡋᑑ࿨ࢆᘏ㛗ࡍࡿ SSG1 ኚ␗ᰴࡀྲྀᚓࡉࢀࡓࠋࡉࡽ࡟ࠊSSG1 ኚ␗ᰴࡢゎᯒ࠿ࡽࠊSAM ྜᡂࡢಁ㐍ࡀ ATP ࡢῶᑡ࠿ࡽ AMPK ࢆάᛶ໬ࡋᑑ࿨ࢆᘏ㛗ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ⯆࿡῝࠸ࡇ࡜࡟ࠊSAH ࢆῧຍࡍࡿࡔࡅ࡛ࡶ SAM ࢆ㧗⵳✚ࡋࠊᑑ࿨ࢆᘏ㛗ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡋ࠿ࡋࠊSAH ࡀᑑ࿨ࢆᘏ㛗ࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࡣ୙࡛᫂࠶ࡗࡓࠋࡑࡇ࡛ᮏ◊✲࡛ࡣࠊSAH ࡟ࡼࡿᑑ࿨ᘏ㛗࣓࢝ࢽࢬ࣒ࡢゎ᫂ࢆ┠ᣦࡋゎᯒࢆ⾜ࡗࡓࠋ➨୍❶ sko1'◚ቯᰴࡣࢢࣜࢭ࣮ࣟࣝྜᡂ⣔ࢆ௓ࡋ࡚㓟໬ࢫࢺࣞࢫ⪏ᛶ࡜ᑑ࿨ᘏ㛗ࢆ♧ࡍ㸦ཧ⪃ㄽᩥ 1㸧  ᑑ࿨ᘏ㛗ࡣ㓟໬ࢫࢺࣞࢫ࡞࡝ᵝࠎ࡞ࢫࢺࣞࢫ⪏ᛶ࡜㛵㐃ࡍࡿࡇ࡜ࡀከ࠸ࠋࡑࡇ࡛ࠊhog1'◚ቯᰴࡢ㓟໬ࢫࢺࣞࢫឤཷᛶࢆᢚᅽࡋࡓ sko1-18 ኚ␗ᰴ࡟࠾࠸࡚ࠊ⤒᫬ᑑ࿨ࢆᐃࡋࡓࠋࡑࡢ⤖ᯝࠊsko1-18

ኚ␗ᰴࡣ hog1'◚ቯᰴࡢ▷࿨ࢆᢚᅽࡋࠊࡉࡽ࡟ sko1'◚ቯᰴࡣ㔝⏕ᰴࡼࡾᑑ࿨ࢆᘏ㛗ࡋࡓࠋࡇࡢࡇ࡜
࠿ࡽࠊSko1 ࡢ◚ቯ࡟ࡼࡿ Sko1 ᶆⓗ㑇ఏᏊࡢ㌿෗ᢚไゎ㝖ࡀᑑ࿨ᘏ㛗࡟㛵ࢃࡿࡇ࡜ࡀண᝿ࡉࢀࡓࠋᑑ࿨ไᚚ࡟㛵ࢃࡿ Sko1 ࡢᶆⓗ㑇ఏᏊࢆ᥈ࡍࡓࡵࠊ㧗ᾐ㏱ᅽࢫࢺࣞࢫࡀ HOG ⤒㊰ࢆάᛶ໬ࡋࠊࢢࣜࢭ࣮ࣟࣝྜᡂࡢಁ㐍࡟ࡼࡾᑑ࿨ࢆᘏ㛗ࡍࡿࡇ࡜࡟╔┠ࡋࡓࠋsko1'◚ቯᰴ࡟࠾࠸࡚ࢢࣜࢭ࣮ࣟࣝྜᡂ࡟
㔜せ࡞ GPD1/2 㑇ఏᏊࢆ◚ቯࡋࡓ࡜ࡇࢁࠊsko1'◚ቯᰴࡢᑑ࿨ᘏ㛗࡜㓟໬ࢫࢺࣞࢫ⪏ᛶࡀᾘኻࡋࡓࠋ
ࡲࡓࠊsko1'◚ቯᰴ࡟࠾ࡅࡿ GPD1/2 㑇ఏᏊࡢ㌿෗㔞ࢆᐃࡋࡓ࡜ࡇࢁࠊGPD1 ࡣ⣙ 1.8 ಸቑຍࡋ࡚࠸ࡓࠋࡇࢀ࡟ࡼࡾࠊࢢࣜࢭ࣮ࣟࣝྜᡂ⣔ࡀᑑ࿨ไᚚ࡜㓟໬ࢫࢺࣞࢫᛂ⟅࡟࠾ࡅࡿ Sko1 ࡢ㔜せ࡞ୗὶᅉᏊ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ➨஧❶ SAH ࡣ࣓ࢳ࢜ࢽࣥไ㝈ࢆᶍೌࡋ࡚ᑑ࿨ࢆᘏ㛗ࡍࡿ㸦ཧ⪃ㄽᩥ 2㸧 SAH ࡟ࡼࡿᑑ࿨ᘏ㛗࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡓࡵࠊࡲࡎ㔝⏕ᰴ࡟ SAH ࢆῧຍࡋࡓ㝿ࡢ࣓ࢱ࣑࣎ࣟࢡ
ࢫゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊSAH ࡔࡅ࡛࡞ࡃ SAM ࡢ㧗⵳✚ࡶほᐹࡉࢀࠊSAH ࡣ SAM ྜᡂࢆಁ㐍ࡋ࡚࠸ࡿ࡜ண᝿ࡋࡓࠋSAM ࡢྜᡂ࡟ࡣ࣓ࢳ࢜ࢽࣥ(Met)ࡀᚲせ࡛࠶ࡿࡓࡵࠊSAM ྜᡂࡢάᛶ໬ࡣ Metࢆᾘ㈝ࡍࡿࠋ࣓ࢱ࣑࣎ࣟࢡࢫࡢ⤖ᯝ࠿ࡽࠊSAH ῧຍ᫬ࠊ࢔࣑ࣀ㓟ࡢ୰࡛ Met ࡢࡳ᭷ព࡟ῶᑡࡋ࡚࠸
ࡓࠋࡑࡇ࡛ࠊSAH ῧຍ᫬ࡢ Met ࡢῶᑡࡀ SAM ྜᡂࡢಁ㐍࡟ࡼࡿࡢ࠿ࠊ[methyl-13C]Met ࢆ⏝࠸࡚ゎᯒࡋࡓࠋࡑࡢ⤖ᯝࠊSAH ࡣ⣽⬊ෆࡢ[methyl-13C]Met 㔞ࢆ᭷ព࡟ῶᑡࡉࡏࠊ[methyl-13C]SAM ࢆቑຍࡉࡏࡓࠋࡇࢀ࡟ࡼࡾࠊSAH ࡀ SAM ྜᡂࢆಁ㐍ࡋࡓ⤖ᯝࠊ⣽⬊ෆࡢ Met 㔞ࢆపୗࡉࡏࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ௨ୖࡢ⤖ᯝࡼࡾࠊSAH ࡢῧຍࡀ MetR ࡢ೺ᗣຠᯝࢆᶍೌࡍࡿ࡜ண᝿ࡋࡓࠋMetR ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮౫Ꮡⓗ࡟ᑑ࿨ࢆᘏ㛗ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊ࣮࢜ࢺࣇ࢓ࢪ࣮άᛶࢆᐃࡋࡓ࡜ࡇࢁ

SAH ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮ࡢㄏᑟࢆಁ㐍ࡋࡓࠋࡉࡽ࡟ Tor1 ⤒㊰ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮ࢆ㈇࡟ไᚚࡍࡿࡓࡵࠊ
SAH ࡀ Tor1 άᛶࢆ㜼ᐖࡍࡿ࠿ゎᯒࡋࡓࠋࡑࡢ⤖ᯝࠊTor1 ࡢୗὶᅉᏊ Rps6 ࡢࣜࣥ㓟໬ࣞ࣋ࣝࡀῶᑡ
ࡋࡓࡇ࡜࠿ࡽࠊSAH ࡀ Tor1 άᛶࢆపୗࡉࡏࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡉࡽ࡟ࠊTor1 ࡜࣮࢜ࢺࣇ࢓ࢪ࣮ࡢᚲ㡲ᵓᡂせ⣲ Atg7 ࢆ◚ቯࡍࡿ࡜ࠊSAH ࡟ࡼࡿᑑ࿨ᘏ㛗ຠᯝࡀᾘኻࡋࡓࠋ௨ୖࡢࡇ࡜࠿ࡽࠊSAH ࡣMetR ࡢ೺ᗣຠᯝࢆᶍೌࡋ࡚ᑑ࿨ࢆᘏ㛗ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ⥲ᣓ ᮏ◊✲࡛ࡣࠊฟⱆ㓝ẕࡢᑑ࿨ไᚚ࡟㛵ࢃࡿศᏊᶵᵓࢆゎ᫂ࡍࡿࡓࡵࠊࢫࢺࣞࢫᛂ⟅ᛶ⤒㊰࡜⏕యෆࡢ௦ㅰ⏘≀ࡀᑑ࿨ࢆᘏ㛗ࡍࡿ࣓࢝ࢽࢬ࣒ࢆゎᯒࡋࡓࠋ➨୍❶࡛ࡣࠊHOG ⤒㊰ࡢไᚚᅉᏊ Sko1 ࡢᶵ⬟ᢚไࡀࠊhog1'◚ቯᰴࡢ㓟໬ࢫࢺࣞࢫឤཷᛶ࡜▷࿨ࢆᢚᅽࡋࠊࢢࣜࢭ࣮ࣟࣝྜᡂ⣔౫Ꮡⓗ࡟㓟໬ࢫࢺࣞࢫ⪏ᛶ࡜ᑑ࿨ᘏ㛗ࢆ♧ࡍࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ➨஧❶࡛ࡣࠊ[methyl-13C]Met ࢆ⏝࠸࡚ࠊSAH ࡀSAM ࡢྜᡂࢆಁ㐍ࡋ Met ࢆᾘ㈝ࡍࡿࡇ࡜࡛ࠊ⣽⬊ෆࡢ Met ࣞ࣋ࣝࢆῶᑡࡉࡏࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
ࡉࡽ࡟ࠊSAH ࡣ Tor1 ࢆ㜼ᐖࡋ࣮࢜ࢺࣇ࢓ࢪ࣮ࢆάᛶ໬ࡋࡓࡓࡵࠊMetR ࡢ೺ᗣຠᯝࢆᶍೌࡋ࡚࠸ࡿࡇ࡜ࡀண᝿ࡉࢀࡓࠋࢫࢺࣞࢫᛂ⟅ᛶ⤒㊰ࡣ㧗➼⏕≀࡟ࡲ࡛㧗ᗘ࡟ಖᏑࡉࢀ࡚࠾ࡾࠊSAH ࡢ೺ᗣຠᯝࡣከ⣽⬊ࣔࢹࣝ⏕≀ࡢ⥺⹸࡛ࡶ☜ㄆࡉࢀࡓࡇ࡜࠿ࡽࠊᮏ◊✲ࡢᡂᯝࡣࣄࢺࡢ೺ᗣ࡬ࡢᐤ୚ࠊࡲࡓຍ㱋ᛶ⑌ᝈࡢ⌮ゎ࡬ࡢᛂ⏝ࡀᮇᚅࡉࢀࡿࠋ

ཧ⪃ㄽᩥ㸦Ꮫ఩せ௳ㄽᩥ㸧
[1] Koji Masumura, Sachi Matsukami, Kumiko Yonekita, Muneyoshi Kanai, Kazunori Kume, DaiHirata, Masaki Mizunuma, SKO1 deficiency extends chronological lifespan in Saccharomyces

cerevisiae, Bioscience, Biotechnology, and Biochemistry, 83(8), 1473-1476 (2019).
[2] #Takafumi Ogawa, #Koji Masumura, Yuki Kohara, Muneyoshi Kanai, Tomoyoshi Soga,
Yoshikazu Ohya, T. Keith Blackwell, Masaki Mizunuma, S-adenosyl-L-homocysteine extends
lifespan through methionine restriction effects, Aging Cell, 21(5), e13604 (2022).
#Takafumi Ogawa and Koji Masumura contributed equally to this work.

㛵㐃ㄽᩥ[1] ┈ᮧ ᫭ྖ, Ỉ἟ ṇᶞ, 㓝ẕࡢ࣓ࢳ࢜ࢽࣥ௦ㅰ⣔࡟ࡼࡿᑑ࿨ไᚚᶵᵓ, ᭶หࠕ⣽⬊ࠖ, 52 ᕳ, 11 ྕ,58-61, 2020.