Form 1

2017 Report Form for Collaboration with
Research Center for Biomedical Engineering

Year/month/date2031

Numberdate:

Date /Month/Year
19/03/2018

To Chairman, Board of Directors, Research Center for Biomedical Engineering

Affiliation
Title
NameAddress

Phone
Fax
E-mailApplicant
Karlsruhe Institute of Technology (KIT)
Head of Department
Accelerator Research and Development + Operations II
Bründermann, ErikKIT CN IBPT Bldg. 345
Hermann-von-Helmholtz-Platz 1
D-76344 Eggenstein-Leopoldshafen, Germany+49 721 608 28576+49 721 608 26789
erik.bruendermann@kit.edu
Report Form for Collaboration Research（和）生体医歯検査応用のための非侵襲・非破壊テラヘルツイメージング技術の研究
Research Theme

Research Area

Research Period（英）Non-invasive and non-destructive terahertz imaging for diagnostics and bio-medicalapplications
1. Biomaterials
2. Bioengineering
3. Functional molecules
4 . Chemistry/Electrical Engineering/Mechanical Engineering/Materials Science○

From:Date/month/Year
17/04/2017

To: Date/month/Year
31/03/2018

Applicant Organization
Name
Bründermann, Erik

Department
Karlsruhe Institute of Technology (KIT),
Institute for Beam Physics and Technology(IBPT)

Title
Head ofDepartment, Dr.

Role
Project leader

Hiromoto, Norihisa

Shizuoka University, Graduate School ofscience and technologyProfessor, Dr.

Collaborator(Measurement)

Tripathi, Saroj

Shizuoka University, Faculty of Engineering

Associate
Professor, Dr.

Collaborator(Analysis)

Collaboration Partners
Research Centerinthe静岡大学電子工学研究所 ナノシステム集積化分野 教授
猪川 洋
Research Institute of Electronics, Shizuoka University
Professor Dr. Inokawa, Hiroshi

Research Results (Including Purpose, Results, Figures, etc.)
At KIT several THz sources and detection systems were prepared, which enable the testing of THz pixel detectors
and arrays developed at Shizuoka University. N. Hiromoto also visited KIT in the framework of the MOU
between KIT and SU from September 9th to 16th in 2017 to review available sources and for research discussions.
Besides accelerator-based THz sources such as coherent synchrotron radiation (CSR) from the Karlsruhe Research
Accelerator (KARA, Fig. 1) with an operator-defined time-structure (Fig. 2), emission spectrum (Fig. 3) and beamprofile (Fig. 4), there are laser-based THz sources such as THz time-domain systems (Fig. 5). One further example
is the use of a LiNbO 3 prism to generate high power THz pulses in the frequency range around 0.3 to 0.5 THz.
The beam profile of this THz source was detected by a commercial about 100,000 pixel pyroelectric camera (seeYan et al. and Schlott et al.). The THz sources can serve as test systems for RIE’s detectors. Recent technology
advances (see Caselle et al.) allow very high data rates, for example, produced by a sampling system such as theKarlsruhe Pulse Taking Ultra-fast Readout Electronics (KAPTURE). The sampled data is processed in real-timeby a heterogeneous FPGA and GPU architecture operating up to 6.5 GB/s continuously. Such a technology opens
the path to a read-out system for very large arrays with a high number of pixels and, at the same time, large
effective number of bits (ENOB) to measure a wide dynamic range of the employed pixel detector. E.
Bruendermann and collaborators of SU had a meeting to discuss on the research results and the future plans at SUin March 22nd to 26th, 2018.

Δt = 100 ns
Fig.1: Karlsruhe Research Accelerator (KARA) at KIT

Fig. 3: Calculation of THz CSR spectrum (fromSteinmann et al., arXiv:1710.09568)

Fig.2: Example of time structure of THz CSR

Fig. 4: Example measurement of the spatial
beam profile in a distance of several metersfrom the electron storage ring KARA

Fig. 5: Typical frequency coverage of aTHz time-domain spectrometer sourceΔν = 5 THz

List of Publications Related to the Collaboration Research(1) M. Caselle, L.E. Ardila Perez, M. Balzer, A. Kopmann, L. Rota, M. Weber, M. Brosi, J. Steinmann, E.
Bründermann, and A.-S. Müller, “KAPTURE-2. A picosecond sampling system for individual THz pulses withhigh repetition rate,” JINST 12 C01040 (2017). DOI: 10.1088/1748-0221/12/01/C01040(2) J.L. Steinmann, M. Brosi, E. Bründermann, M. Caselle, B. Kehrer, L. Rota, P. Schönfeldt, M. Schuh, M.
Siegel, M. Weber, A.-S. Müller, “Continuous bunch-by-bunch spectroscopic investigation of the micro-bunching
instability”, arXiv preprint, arXiv:1710.09568 (26 Oct. 2017)(3) A. Banerjee, H. Satoh, A. Tiwari, Catur A., Eko T. R., N. Hiromoto and H. Inokawa, “Width dependence ofplatium and titanium thermistor characteristics for application in room-temperature antenna-coupled terahertzmicrobolometer,” Jpn. J. Appl. Phys. 56, 04CC07 (23 Mar. 2017).
List of Presentations ( Conference, Meeting, etc)
(1) M. Yan, E. Bründermann, S. Funkner, A.-S. Müller, M.J. Nasse, G. Niehues, R. Ruprecht, M. Schedler, T.
Schmelzer, M. Schuh, M. Schwarz, B. Smit, M.M. Dehler, N. Hiller, R. Ischebeck, V. Schlott, T. Feurer, M.
Hayati, “Design of a Time-resolved Electron Diagnostics Using THz Fields Excited in a Split Ring Resonator at
FLUTE,” Proc. Int. Beam Instrumentation Conf.: Barcelona, 11-15 Sep 2016, TUPG56 (published Feb 2017)(2) V. Schlott, M. Dehler, R. Ischebeck, M. Moser, T. Feurer, M. Hayati, Z. Ollmann, R. Tarkeshian, E.
Bründermann, S. Funkner, A.-S. Müller, M.J. Nasse, G. Niehues, R. Ruprecht, T. Schmelzer, M. Schuh, M.
Schwarz, M. Yan, “Status of the THz Streaking Experiment with Split Ring Resonators at FLUTE”, Proc. Int.
Beam Instrumentation Conf., Grand Rapids, 20-24 Aug 2017, TUPCC16.
(3) M. Caselle, L.E. Ardila Perez, M. Balzer, A. Kopmann, L. Rota, M. Weber, M. Brosi, J. Steinmann, E.
Bründermann, A.-S. Müller, KAPTURE-2. A picosecond sampling system for individual THz pulses with highrepetition rate, JINST 12, C01040 (2017). DOI: 10.1088/1748-0221/12/01/C01040, also held as a presentation at
the Topical Workshop on Electronics for Particle Physics (TWEPP)(4) J.L. Steinmann, E. Blomley, M. Brosi, E. Bründermann, M. Caselle, B. Kehrer, L. Rota, P. Schönfeldt, M.
Schuh, M. Siegel, M. Weber, A.-S. Müller, Anke-Susanne, 4-Channel Single Shot and Turn-by-Turn Spectral
Measurements of Bursting CSR, Proceedings of the International Particle Accelerator Conference (IPAC’17),
Copenhagen, DK, 14-19 May 2017, pp. 231-234 (2017)(5) A. Banerjee, H. Satoh, Y. Sharma, A. Tiwari, N. Hiromoto, and H. Inokawa, “Optimization of Narrow Width
Effect on Titanium Thermistor in Uncooled Antenna-Coupled Terahertz Microbolometer,” 2017 International
Conference on Solid-State Devices and Materials (SSDM 2017),(Sendai International Center, Sendai, Japan),(Sept. 2017).
(6) A. Banerjee, H. Satoh, Y. Sharma, A. Tiwari, N. Hiromoto, and H. Inokawa, “Optimization of Platinum andTitanium Thermistor in Uncooled Antenna-Coupled Terahertz Microbolometer Fabrication,” International
Conference organized by Department of Physics and Nanotechnology (ICONN 2017), (SRM University, Chennai,India), (11 Aug. 2017).
(7) N. Hiromoto，A. Banerjee，H. Satoh, H. Inokawa, M. Aoki, E. Bründermann, “Development of THz

antenna-coupled bolometers with a meander-line thermistor,” The 27th JSIR Symposium 2018 (Osaka City Univ.,Osaka, Japan), 2017-IR-09 (Oct. 2017). (in Japanese)(8) N. Hiromoto，A. Banerjee，M. Aoki, H. Satoh, H. Inokawa, “Study on THz antenna-coupled bolometers withminutes meander structures,” The 78th JSAP Autumn Meeting, 2017(Fukuoka Convention Center, Fukuoka),
8a-A405-10 (Sep. 2017). (in Japanese)
List of Awards
During the period of the collaborative research, E. Bründermann received on May 17, 2017 a JSPS BRIDGE
award in part due to a support letter by Prof. N. Hiromoto. E. Bründermann commenced the award on March 14,2018 in Japan and attended research meetings in the visit to Shizuoka University, Hamamatsu Campus, within theperiod from March 21 to 27, 2018.

Research plan for the next year (from April 1, 2018 to March 31, 2019), if the collaboration research is continued.
Prior consent from the collaboration partner in the Research Center is necessary.
The applicant desires to continue the collaboration research.
Research objective: long-term with intention to develop and explore new methods and technologies fordiagnostics. Main goal is real-time terahertz (THz) imaging with extreme-performance multi-pixel, while
exploring the potential from video-mode towards ultrafast imaging. The proposed research is to develop newdetection and imaging technologies at the Research Institute of Electronics (RIE) at Shizuoka University andemploy them at the accelerator and laser facilities at the Karlsruhe Institute of Technology (KIT) for diagnostics
and in biomedical applications at Shizuoka University and affiliates. The project leader (PL) will collaborate on
the detection method using THz antenna-coupled bolometers, which have the potential for multi-pixel arrays andspectral imaging applications.
About the PL: The PL heads the department of Accelerator Research at KIT to explore new accelerator anddetector technologies for application-driven research towards life sciences and medicine. He is involved inresearch at FLUTE (Ferninfrarot Linac- Und Test Experiment), a linear accelerator-based test experiment at KIT,
which will commence operation in the near future. The experiment shall provide stable and reproducible operation
and will allow tuning of frequency, pulse duration and THz intensity over a very wide range. Emission stability
will enable the systematic study of heterogeneous materials such as complex aqueous solutions with biomolecules
relevant to medicine, biocompatible materials, cells and tissue. A further required key-element for this research
will be efficient, well-defined detectors for THz radiation currently in development by the RIE. The PL is part of a
3-year project on plasma accelerator development and project leader for the KIT contribution, funded since 2017as a future topic by the strategic initiative fund of the Helmholtz Association’s president. Plasma accelerators
promise a size reduction of conventional accelerators by several orders of magnitude, so that these accelerators
could enable widespread use in science, industry, and medicine.
MOU: The intended research will be considered to commence in the framework of the signed MOU betweenKarlsruhe Institute of Technology (KIT), Germany, and Shizuoka University, Japan (final signature was on Nov.
24th, 2015 to foster exchange of personnel and students, see further information on KIT website in section onInternational Affairs: “Cooperating with Japan”, http://www.intl.kit.edu/ischolar/8214.php).
Environment for biomedical applications: The future biomedical applications can rely on the long-standing
collaboration of the PL with Shizuoka University, affiliates and partners in biology and medicine, which aredocumented by peer-reviewed publications. KIT provides an ideal environment for such future collaborative
research activities. For example, KIT hosts the European Zebrafish Resource Center (www.ezrc.kit.edu), which
provides over 2000 plasmids. KIT also contributes to the Helmholtz Repository of Bioparts (HeRBi) with model
systems for biomedical research and a stock collection containing several thousand mutations. In addition, theEuropean Molecular Biology Laboratory (EMBL) is located nearby, in Heidelberg, and is Europe's flagshiplaboratory for basic research in molecular biology. The cooperation between Heidelberg University and KIT atKarlsruhe is governed by the “Heidelberg-Karlsruhe Research Partnership” (HEiKA).
Research plan: develop and explore new methods and technologies for diagnostics to allow real-time terahertz

(THz) imaging with extreme-performance multi-pixel, while exploring the potential from video-mode towards
ultrafast imaging. New detection and imaging technologies are in development at RIE at Shizuoka University.
Tests are envisioned at the accelerator and laser facilities at KIT. For comparison and accurate power
measurements, a 64x64 pixel commercial camera sensitive up to 0.7 THz, a commercial pyroelectric camera, andPTB-calibrated THz power meters are available at KIT.