2022

Annual Report

2-8 Yamadaoka,Suita,Osaka , 565-0871 Japan
info@cider.osaka-u.ac.jp

11
Message from the
DirectorContents
01

Message from Director

02

Vission and Mission

03

Organization

06■ Division of Scientific Information and Public Policy
Behavioral Public Policy Team・Behavioral Economics Unit・Human Science Unit
Information Analysis Team・Mathematical Analysis Unit
・ELSI & Technology Unit

14

26

34

■ Division of Microbiology and Immunology
Human Single Cell Immunology Team
Regulation of Host Defense Team
Virus Control Team
Clinical Biotechnology TeamAll Osaka University Research Project

Humankind has battled infectious diseases throughout its history. Highly lethal
infectious diseases have arisen countless times to date, but people came to believe thatsuch diseases could be eradicated by the end of the 20th century through the development of vaccines and therapeutic drugs. The novel coronavirus pandemic that began in
2019, however, has exposed contemporary society’s continued vulnerability toinfectious diseases. Conquering the emergent and re-emergent infectious diseases
that will threaten society from now on is a common challenge for the whole of humankind.
With the aim of protecting “our life and activity” from the threat of infectious diseases,
Osaka University established the Center for Infectious Disease Education and Research(CiDER) in April 2021. The Center brings together Osaka University’s capabilities acrossthe disciplinary borders of humanities, social sciences, and natural sciences, partneringwith research institutes and industry players within Japan and internationally as it seeks
to conquer emerging and re-emerging infectious diseases through collaboration acrossthree divisions: the Division of Scientific Information and Public Policy, the Division of
Microbiology and Immunology, and the Division of Fostering Required Medical Human
Resources.
As a center for comprehensive research and education, CiDER is committed to playing
a leading role in infectious disease research and human resource development in Japanand internationally. All members of CiDER will work together to discharge our missionof protecting “our life and activity” from the threat of infectious diseases, and to enable
the center to function as a hub that is open to the world. We appreciate your continued
encouragement and support.

Yoshiharu MATSUURA
Director,
Center for Infectious Disease Education and Research■ Division of Fostering Required Medical Human Resources
Specimen Analysis Team
Infection Control Team
Medical Informatics Team
Publications
Preprints

1

11

Vision and Mission

Organization

Supervisor
Yasufumi KANEDA
Senior Executive Vice President

CiDER pursues infectious disease-related research, education andtraining, information-sharing, and practical application of researchfindings in wider society, with the aim of preparing for threats
posed by infectious diseases in future and protecting "Our life andactivity" as well as contributing to the maintenance of social andeconomic activity.

Director
Yoshiharu MATSUURA
Specially Appointed Prof.

Deputy Director

VisionConvergence of knowledge : to protect“ life and activity ” from infectious diseases

Fumio OHTAKE

Akira KIKUCHI

Specially Appointed Prof.

Specially Appointed Prof.

Division of Scientific Information
and Public Policy

Division of Microbiology and
Immunology

Division of Fostering Required
Medical Human Resources

Provision of comprehensive(scientificevidence-based) information on
infectious diseases to society

Promotion of comprehensive researchand development on infectious disease
prevention, diagnosis, and treatment

Cultivation of leaders in infectious
disease control and supprt for healthcare workers to acqire the latest skills
related to infectious diseases

Divisional Director

Divisional Director

Divisional Director

Takashi NAKANO

Kiyoshi TAKEDA

Eiichi MORII

Prof.

Prof.

Prof.

Research Center for Nuclear Physics

MissionTo become a hub for infectious diseaseeducation and research

Management Director

Graduate School of Medicine

Graduate School of Medicine

Deputy Divisional Director

Deputy Divisional Director

Deputy Divisional Director

Asako MIURA

Masato OKADA

Satoshi KUTSUNA

Prof.

Prof.

Prof.

Graduate School of Human Sciences

Research Institute for Microbial
Diseases

Graduate School of Medicine

科学的エビデンスに基づく感染症に
Deputy Divisional Director
対する社会への総合的な情報発信

Atsuo KISHIMOTO

Prof.

Institute for Datability Science22

Behavioral Economics Unit

Human Single Cell Immunology Team

Human Sciences Unit

Regulation of Host Defense TeamSpecimen Analysis Team
Infection Control Team

Mathematical Analysis Unit

Virus Control Team

Medical Informatics TeamELSI & Technology Unit

Clinical Biotechnology Team33

outline
The team is composed of members from diﬀerent organizations and fields, andcollects and analyzes information necessary for risk assessment and policy evaluation, and carries out evidence-based policy making (EBPM) and information
dissemination.
We will address Unexpected Health Issues (UHI), such as infectious diseases,
which are diﬃcult to predict in advance but have the potential to significantly
damage physical and mental health, by integrating the humanities and sciences,and enhance the resilience of society against UHI.

DIVISION OF SCIENTIFIC INFORMATION
AND PUBLIC POLICYBEHAVIORAL PUBLIC POLICY TEAM
Behaviorall Economicss Unit
Human Science Unit
INFORMATION ANALYSIS TEAM
Mathematical Analysis UnitELSI & Technology Unit
Divisional Director

Takashi NAKANO
Prof. ,
Research Center for Nuclear Physics

4

1

2

5

DIVISION OF SCIENTIFIC INFORMATION
AND PUBLIC POLICYBEHAVIORAL PUBLIC POLICY TEAM
Behavioral Economics Unit

The Behavioral Economics Unit is conducting eﬀectiveness verification of infection
control measures using behavioral economics, a field of study that incorporates
psychological characteristics into economics, and causal inference, a method ofanalyzing causal relationships based on data. Specifically, we are developing messages
that apply behavioral economics to encourage infection prevention and vaccination
behavior and examining their eﬀectiveness, examining the eﬀectiveness of priority
measures to prevent the spread of infectious diseases, and analyzing the impact ofinfection control measures such as declaring a state of emergency and temporarily
closing all schools nationwide on education and socioeconomic activities.

Unit Leader

Fumio OHTAOHTAKE
TAKE
Specially Appoin
Appointed
ointed Prof.
He is a speciall
specially
ally appointed professor in theCenter for Inf
nfectious Disease Education and
Infectious
Research (CCiDER), and adjunct professor in the(CiDER),
Graduatee SchoolSof Economics at Osaka Univerearnedsity. He e
arned his M.A. and a Ph.D. from Osaka
University
Univers
rsity in 1985 and 1996, respectively, and a
B.A. fromfr
Kyoto University in 1983. He is an
exec
cutive director of the Association of Behavexecutiveiora
al Economics and Finance, and a former
ioral
presidentent of tthe Japanese Economic AssociaAssociation. His research
earch topics are behavioral
economics, labor econom
nomics, income distribu
economics,
distribu-tion, and household behavior
vior. He is also a
behavior.
recipient of the 2005 Nikkei Prizeze forfo Excellent
Books in Economic Science; the 200505 Suntory
Prize for Social Science and Humanities;
es; the2005 Economist Prize; the 2006 Ishikawa PrizePrizof the Japanese Economic Association; and thee2008 Japan Academy Prize.

Staff
Shuhei KiTAMURA(Specially Appointed Assoc.Prof.)
Shusaku SASAKI(Specially Appointed Assoc.Prof.)

26

Applying behavioral science andeconomics to infectious disease
control
Production of nudge messages to encourage people totake antibody tests for rubella
Japan has not achieved mass immunity to rubella; menborn between FY1962 and FY1978 have low levels ofrubella antibodies due to the fact that they were notsubject to routine immunization and did not have many
natural infections. For this reason, local governments
are sending free antibody testing and vaccination
coupons to men of this generation starting in FY2019. In
order to increase the uptake rate of antibody testing,
we developed a message applying behavioral economics and tested its eﬀectiveness. Based on the results ofthe study, an awareness leaflet and Youtube video were
produced; the Youtube video was well received and has
been viewed a total of 740,000 times as of February 21,
2023.
Kato, Sasaki, Ohtake, “Adding Nudge-based Reminders
to Monetary Incentives for Promoting Rubella Antibody
Testing and Vaccination,” Center for Infectious Disease
Education and Research, Discussion Paper, DP003,
2022.

Hygiene education in schools and hand hygiene
behavior under COVID-19
NThe role of social ties, preferences regarding care forothers, and cultural traits in enhancing community
resilience to crises such as COVID-19 and minimizing
citizen vulnerability is critical. However, little is known
about the pathways through which such cultural norms
regarding personal preferences and social behaviors
are formed. Therefore, we conducted a study on
self-management of hand hygiene before a pandemic,
during an emergency, and after the lifting of an
emergency in Japan, focusing on handwashing education in elementary schools, handwashing experiencesat shrines during childhood, and individual reciprocity.
The results revealed that these education, experience,and individual attributes correlated with hand hygiene
behavior under COVID-19.
Lee, Sasaki, Kurokawa, and Ohtake “The school education , ritual customs , and reciprocity associated withself regulating hand hygiene practices during COVID
19 in Japan,” BMC Public Health, 2022

Percentages of respondents in different
prefectures who received handwashingeducation at their elementary school

7

DIVISION OF SCIENTIFIC INFORMATION
AND PUBLIC POLICY

Understanding "human beings" fromdiverse perspectives and applying
them to infectious disease control

BEHAVIORAL PUBLIC POLICY TEAM
Human Science Unit

Longitudinal Sensing of Social Psychology

Unit Leader

Ethnography in the Field of "Care"

To provide the basis for policy proposals on Unexpected Health Issues (UHI), which are
diﬃcult to predict in advance but have the potential to significantly damage physicaland mental health, we take a complementary approach that combines contrasting
perspectives on quantity and quality, the whole and the individual, with particularattention to "human beings," the members of society. Current projects include: social
sensing of the social impact of UHI; ethnography of people facing social diﬃculties andinterpersonal support workers; development of health communication theories andtechniques for unknown risks; and health promotion to increase resilience to UHI.

Asako MIURARA
Prof.,
SchoolGraduate Schooool of Human Sciences
In 2002, she recereceived
eceived her Ph.D. (Human Sciences) from Osaksaka University. After serving as a
Osakaprofessor at Kwansei Gakuin University and as a
specially-a
appointed professor (full-time) at the
specially-appointed
Graduatete School of Engineering Science, Osaka
University,
Univers
rsity, she has been in her current position
since 2019.
2
She specializes in social psychology.
Her rresearchesearch interest has been consistent since
psycholo-the beginning
beginnof her studies in social psycholo
gy: elucidating
ating thetmechanisms by which"some-communication andd interaction
int
create "something new."

Staff
Yasuhiko MURAKAMI(Prof. Graduate School of Human Sciences)
Elli W. SUGITA(Prof. Graduate School of Human Sciences)
Kei HIRAI(Assoc. Prof. Graduate School of Human Sciences)
Mao YAGIHASHI(Specially Appointed Assis. Prof.)

8

In order to capture the social psychology of theinfection disaster, since the end of January 2020,
we have continued to conduct a panel survey ofthe general public (once every two months) to
examine changes over time in Japan and afive-country survey (once a year) to understandthe characteristics of Japan from an international
perspective. In FY2022, we analyzed the panel
survey data from the perspective of "retrospective bias." When the respondents were asked toretrospectively look back January 2020, they greatly underestimated both their level of interest in
the pandemic and their perception of the dread and unknown risks of infection, and that this bias
was greater for respondents whose psychological swing during the year between the two periods
was smaller. These results indicate that people are not immune from retrospective bias and,because of this, it is significant that we have continued to collect data since the beginning of theinfection disaster.
The data from seven of the interviews conducted since 2020 withsocially deprived people who have suﬀered great hardship due to theinfection disaster were analyzed using phenomenological qualitative
research methods and summarized in the book "Who are the 'Young
Carers'? The book showed that children in middle-class nuclear
families are more likely to face diﬃculties because isolation, rather
than major adversity events such as poverty or family arrest, is theburden on the children. The need for a support system that accompanies both parents and children, rather than a consultation service, isalso indicated.
In addition, we published a picture book as a teaching material for life story work (a technique forchildren who could not grow up with their parents to reconstruct the history of interaction with
their parents and confirm the parent-child relationship in order to achieve psychological stability)
for children who grow up in social foster care. The book will be used for training with children andstaﬀ at children's homes and other facilities, mainly in Osaka Prefecture.

Health Promotion

Considering the impact of COVID-19, the need to address issues of
discrimination and Comprehensive Sexuality Education (including
menstruation education) in addition to preventive measures ofinfectious diseases (such as handwashing) was recognized to be crucial
in school health settings. Thus, in Y2022 we continued to broadly assess
the current status related to school health and implement pilot classes.
In Japan, we have collaborated with UNESCO schools across Japan byconducting online surveys, and visited some schools in Oita, Fukuoka,
and Nagano Prefectures. Another research of the impact of COVID-19
on the school life of linguistic minority residents and the response ofJapanese health care to a multicultural society is ongoing. In addition,
research on the response to COVID-19 and school health policies in overseas schools has been
conducted as EduPort Nippon in collaboration with experts in the Philippines, Indonesia, Guam,
Palau, Fiji, and Tonga, with regular online meetings. We also worked with experts in Laos and Nepal
to develop health teaching materials for elementary and junior high school students and put theminto practice in the field in those countries, including Japan.

9

DIVISION OF SCIENTIFIC INFORMATION
AND PUBLIC POLICYINFORMATION ANALYSIS TEAM
Mathematical Analysis Unit

Mathematical Analysis Unit researches the mathematical representation and modelingof infectious diseases through both microscopic and macroscopic approaches thatincorporate the concepts of reduction and emergence in natural science. Analyzing
the information based on scientific and mathematical aspects, we aim at integrating
natural and social sciences and disseminating an accurate information that will be theevidence of policy making.

Unit Lead
Leaderader

YoichiYoich
hi IKEDAProf.
Prof. aatt CiDER since 2022. His mainresea
earrch field is theoretical hadron andresearchclea
ar physics.
phy
nuclearat ideas in quantum physics
He found that
read ofo infections
are applicable to spreadnd proposedpamong human societies, andbrokenken-link
a new epidemic model, the broken-linkuesmodel. Based on ideas and techniquesof mathematics and physics, heaims to integrate natural and social
sciences.

Staff
Takashi Nakano(Prof. ,Research Center for Nuclear Physics)
Kenji Sasaki(Specially Appointed Associate Prof. )10

Unveiling microscopic and macroscopic
mechanisms of infectious diseases
through mathematical science
Systematic analysis of COVID-19 transmission using
K-indicator
We performed a systematic analysis of the
global trend of COVID-19 using a broken-link
model and K-values, and it can be expressedin terms of broken-link probability. Analyzing
the trend in Taiwan, we found that thestringent quarantine (surveillance) measures
for infected people was eﬀective to suppress
the number of infected people. For Shanghai
where a lockdown was done in addition tostrict quarantine measures, we found that
there was no change in the broken-linkprobability before and after the lockdown,
and its value was comparable to that in
Taiwan under strict surveillance, indicatingthat the lockdown on top of strict surveillance
for infected persons was an excessive
measure. The results are published in thepaper.

Theoretical foundation of new compartmental model,
the broken-link model
We published a paper on the newly proposed“broken-link model”, which describes thenumber of COVID-19 cases on the basis of the
microscopic transmission mechanism (Y.
Ikeda, K. Sasaki, T. Nakano, “A new compartment model of COVID-19 transmission: The
broken-link model”, Int. J. Environ. Res. Public
Health 2022, 19(11), 6864.).
Furthermore, the theoretical foundation of
the broken-link model was developed frommathematical and physical aspects. It was
found that the spread mechanism is theanalogue to the Debye screening in quantum
many-body system. It was also mathematicallyshown that the model can describe thespread of infection, including the eﬀects ofpeople belonging to diﬀerent communities.

11

DIVISION OF SCIENTIFIC INFORMATION
AND PUBLIC POLICYINFORMATION ANALYSIS TEAMELSI & Technology UnitELSI & Technology Unit will work on social implementation through solution-focused
assessment of infection risks at mass gathering events and indirect health risks inpandemics and disasters, as well as theorizing risk communication methods for collaboration with stakeholders. In addition, we will keep an eye on the trends of academic
publications and people's recognition and awareness of the research results that form
the basis for news and other information. Through these activities, we will develop
society-aligned sciences to disseminate the findings.

Unit Leader

Atsuo KISHIMKISHIMOTOHIMOTO
Prof., Institutee for
fo Datability ScienceHe graduated fromfro
Kyoto University with aPh.D. (Economimics) degree in 1998. He has(Economics)
worked for theth National Institute of Advanced
Industrial ScienceSc
and Technology (AIST) from1998 to 2014, specialized in the risk assess2014,
ment andnd economic analysis of environmental,
safety and health regulations. He moved to theandUniverersity of Tokyo in 2014 as a project profesUniversity
sor a
att the Graduate School of Public Policy(Gra(GraSPPaSPP). Then, he moved to Osaka University(GraSPP).
in 2017. He works for the Institute for Datability
Science and Researcharch CenterC
on Ethical, Legaland Social Issues, Osaka University. His
research focuses on addressing
ng risksri
stemmingfrom ethical, legal, and social issues
issu(ELSI)
development
accompanying research and developme
pment ofemerging technologies, big data analyticss andaArtificial Intelligence.

Staff
Michio MURAKAMI (Specially Appointed Prof. )Kazuki IDE (Specially Appointed Assoc. Prof. )12

Analysis of information and practicalactivities to bridge the gap between
science and society
Risk analysis and social implementation regarding
mass gathering events and secondary health effects
We clarified the sensitivity of the rapid antigen test for
COVID-19 during the Omicron variant outbreak, andanalyzed the cost and eﬀectiveness of the testing
system for athletes and staﬀ members in reducing theinfection risk. These findings were fed back to sports
oﬃcials, and examples of social implementation wereaccumulated. In addition, we developed a mathematicalmodel for early detection and estimation of the numberof infected individuals in the catchment area based onpractical examples of wastewater-based epidemiology
at the Tokyo 2020 Olympic and Paralympic Village andwastewater treatment plants. Furthermore, we
conducted an assessment of secondary health eﬀects
on physical and mental health after the Fukushimadisaster and the COVID-19 outbreak. Furthermore, we
held a CiDER symposium regarding mass gathering
events was held (see figure), gave a lecture at Knowledge Capital and made eﬀorts to disseminate information widely, including press releases of research results.

CiDER symposium regarding mass
gathering events

Exploration of trends in academic publishing andtheir impact on society, and information sharing
We shared information on trends in academic publishing, including preprints, at the 45th Annual Meeting of
the Molecular Biology Society of Japan (invited lecture).
At that time, we introduced cases related to COVID-19.
We are also attempting to understand the perceptionsof researchers by conducting a questionnaire survey incollaboration with the society.
In addition, we provided online lecture for non-specialists with Knowledge Capital mainly focusing on a topic
on press releases (Figure). It was an opportunity to think
together about how "Research Results" are produced,
known, and utilized in society.
Assoc. Prof. Ide also wrote articles for professionals on
topics such as how to read and understand clinical trials
in the Journal of Practical Pharmacy.

MBSJ2022 & Online lecture with
Knowledge Capital13

outline

DIVISION OF MICROBIOLOGY AND
IMMUNOLOGY

For the development of maneuver for prevention, diagnosis, and treatment of
infectious diseases, it is essential to elucidate the characteristics of pathogenic
microorganisms and the host defense system against pathogens. In this division,
we promote basic research aimed at fundamentally overcoming infectious diseases. In particular, we aim to elucidate not only the characteristics of pathogenic
microorganisms, but also human host defense systems and immune response
mechanisms against pathogenic microorganisms. To this end, we will promotecomprehensive basic research and development across disciplines by bringing
together microbiology researchers, immunology researchers, and clinical medicine researchers.

HUMAN SINGLE CELL IMMUNOLOGY TEAMREGULATION OF HOST DEFENSE TEAM
VIRUS CONTROL TEAM
CLINICAL BIOTECHNOLOGY TEAMDivisional Director

Kiyoshi TAKEDA
Prof. ,
Graduate School of Medicine

14

1

1

2

15

DIVISION OF MICROBIOLOGY AND
IMMUNOLOGY

Focus on the details,
thatʼs where we find the truth

HUMAN SINGLE CELL IMMUNOLOGY TEAM

Sex-specific differences in the immune response to
COVID-19 infection

We focus on the use of single cell biology techniques such as mass cytometry to
decode the complexity of the immune system. We apply this approach to various
settings such as infectious diseases and autoimmunity with a particular focus on theregulation of antibody responses.

Team Leader

James Badger Wing
Assoc. Prof.
I am originally from the UK, and, as partpa of myinfectious
early career training in infectiou
ctious diseases, I
became interested in how
w theth immune systemregulates antibody responses.
respo
sponses. Antibodies areagainstcritical to the fight agai
gainst infection but can also
cause autoimmunity.
autoimmunity
nity. 10 years ago, I moved toJapan join the laboratorylababoratory of Shimon Sakaguchi,
who discovered
ed regulatory T-cells, which are thecells most criticalcrito the control of the immune
system. With
Wi his kind guidance I was able tofocus onn a new type of Treg, T-follicular regulatory cell,
cellll, that controls antibody responses. This
cell iss important to control both vaccine
responses
respo
onses and viral infections. More recently I
wass lucky enough to be able to open a newlaboratory
tory that focuses on the use of mass
cytometry, a technology
technoechnology that allows us toinvestigate the biologyy of millions
mof immune
cells in detail. I would like to humbly thankeveryone for their kind support andnd usinguthese
new technologies I hope to contribute
ute to thefight against infectious diseases.

Staff

We The antibody response to COVID-19 is a key partof our defense against infection. Sex specificdiﬀerences to outcome of infection have also been
described with male sex being a risk factor for
disease. However, since a complex interaction ofrare cell types that are diﬃcult to resolve bycommon techniques our understanding of theseprocesses is incomplete. In this research we used anovel single cell analysis method to examine thestatus of rare cells of immune system in high detail.
This allowed us to confirm that during COVID-19,
cells key to the proper control of antibody production, known as T-follicular regulatory cells (Tfr) are
reduced in all patients. This trend is stronger in malepatients who also show increased numbers ofantibody producing T and B-cells in comparison tofemale patients. A better understanding of thecellular interactions controlling antibody production
in COVID-19 may allow the development of newtreatments to control the disease. Additionally, thefinding that male patients have strong, but dysregulated, antibody production may give us informationthat we must treat male and female COVID-19
patients diﬀerently.

Fiigure 1. Sex biased imbalance of cells
that inhibit or boost antibody production
during COVID-19 infection. T-follicularregulatory cells (Tfr) inhibit antibody
production. T-peripheral helper cells(Tph) stimulate atypical B-cells to form
antibody producing plasma cells.

Proc Natl Acad Sci U S A. 2023; 120 (4),e2217902120. “A sex-biased imbalance between
Tfr, Tph, and atypical B cells determines antibody
responses in COVID-19 patients”
Jonas Nørskov Søndergaard, Janyerkye Tulyeu,
Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki
Murakami, Takayoshi Morita, Yasuhiro Kato,
Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki,
Shimon Sakaguchi, Atsushi Kumanogoh, Yukinori
Okada, and James Badger Wing.
ＤＯＩ：https://doi.org/10.1073/pnas.2217902120

Jonas Nørskov SØNDERGAARD(Specially Appointed Assis
Assis. Prof
Prof. )
Janyerkye TULYEU(Specially Appointed Researcher)
Rika ISHI(Specially Appointed Technical Staﬀ )Laura BARBIERI(Visiting Scientist )16

17

DIVISION OF MICROBIOLOGY AND
IMMUNOLOGYREGULATION OF HOST DEFENSE TEAM
As we’ve learned during COVID-19 pandemic, establishing virus-specific immune
memory is essential for protection from viral infection and is the goal of current
vaccines. Specificity and durability of memory T cells, memory B cells, and neutralizing
antibodies mater for long-term protection from mutant viruses. We study the mechanisms underlying development of long-lasting antibody response, particularly focusing
on follicular helper T cells in germinal centers, and long-lived plasma cells. We also
study how immune system promotes repair of the damaged tissues during respiratory
viral infection, especially by looking at interaction between immune cells and lungepithelial cells. Our research will lead to the development of new vaccine strategies ortherapeutic drugs.

Team Lead
Leaderader

Wataruaru ISEProf.

We study how immune cells fightagainst respiratory virus and develop“memory” for future infection.
Identification of long-lived plasma cells
Antibodies are soluble eﬀector proteins produced byterminally diﬀerentiated B cells, called plasma cells. A
small fraction of plasma cells generated upon infection
or vaccination survive for months or years in bonemarrow, continue to produce neutralizing antibodies,and contribute to long-term protection. We’ve
developed a new experimental system, in which the fateof plasma cells can be traceable. Early plasma cells justarriving at bone marrow are B220hiMHC-IIhi (Fig.1) andshort-lived. Intravital imaging analysis revealed thatmost of such short-lived plasma cells are motile andmigratory (Fig.2). On the other hand, long-lived plasma
cells are B220loMHC-IIlo (Fig.1), and are sessile andimmobilized in the bone marrow environment (Fig.2).
Our study enables to analyze molecular mechanisms
underlying the development of long-lived plasma cells
during infection or vaccination.
Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, YariS, Kikuta J, Ishii M, Kurosaki T, Ise W. Progressive
diﬀerentiation toward the long-lived plasma cellcompartment in the bone marrow. J Exp Med. 2023 Feb
6;220(2):e20221717.doi: 10.1084/jem.20221717.

He gragraduated
aduated from University of Tokyo andfrom graduate school of Agricultural and Life
graduate
Scien
nces, University of Tokyo with a PhD in
Sciences,
Agri
Agriculture
iculture, and joined the faculty there as an
Agriculture,assistant professo
rofessor. After a postdoctoral fellow
professor.
in Howard Hughes Medical
Medi
Institute, Washing
Washing-ton University in St. Louis,, I joined
joi
IFReC, Osaka
University, as a specially appointointed Associate
appointed
Professor, in 2011. Since 2021, He
e has
ha been a
professor and a team leader of regulati
lation ofregulation
host defense team in Division of Microbiolo
ology
Microbiology
and Immunology, CiDER, Osaka University.

Staff
Masako KOHYAMA (Assoc. Prof. )Daiki MORI (Specially Appointed Assis. Prof. )Takuya KOIKE(JSPS Research Fellowship for Young Scientists (PD) )18

19

DIVISION OF MICROBIOLOGY AND
IMMUNOLOGY
VIRUS CONTROL TEAM
Recent COVID-19 pandemic has taught us how humans are vulnerable to unknown
emerging viral diseases. It is diﬃcult to predict the pandemic of emerging andre-emerging infectious diseases. Our research aims to develop a comprehensive
understanding of the viral pathogenesis by clarifying virus-host interactions and tobuild a system that can prepare therapeutic and preventive methods ahead of time.

Team Leaderr

Yoshiharu
Yoshihararu MATSUURA
Speciallyy Appinted
A
Prof.
Dr. Matsuura received his PhD in Veterinary
Medicine from Hokkaido University. He worked
at Daiichi Seiyaku Co. Ltd and National Institutefor Infectious Diseases in Tokyo. Then he went
on to work as a postdoctoral fellow at the NERC
Institute of Virology in Oxford University. He
joined the Research Institute for Microbial
Diseases (RIMD) in Osaka University in 2000 as
Professor and served as Director of RIMD from2015 to 2019. He has been appointed Directorof Center for Infectious Diseases Education andResearch in 2021.

Living with viruses
Secretory glycoprotein NS1 plays a crucial role in theparticle formation of flaviviruses
Flaviviruses, which are globally distributed and cause
a spectrum of potentially severe illnesses, pose amajor threat to public health. Although Flaviviridae
viruses, including flaviviruses, possess similar genome
structures, only the flaviviruses encode the non-structural protein NS1, which resides in the endoplasmic
reticulum (ER) and is secreted from cells after oligomerization. The ER-resident NS1 is known to be involvedin viral genome replication, but the essential roles ofsecretory NS1 in the virus life cycle are not fully understood.
Here we characterized the roles of secretory NS1 in
the particle formation of flaviviruses. We first
identified an amino acid residue essential for the NS1
secretion but not for viral genome replication by using protein-protein interaction network
analyses and mutagenesis scanning. By using the recombinant flaviviruses carrying the identified
NS1 mutation, we clarified that the mutant flaviviruses employed viral genome replication. We thenconstructed a recombinant NS1 with the identified mutation and demonstrated by physicochemical assays that the mutant NS1 was unable to form a proper oligomer or associate with liposomes.
Finally, we showed that the functions of NS1 that were lost by the identified mutation could becompensated for by the in trans-expression of Erns of pestiviruses and host exchangeable
apolipoproteins, which participate in the infectious particle formation of pestiviruses and hepaciviruses in the family Flaviviridae, respectively. Collectively, our study suggests that secretory NS1
plays a role in the particle formation of flaviviruses through its interaction with the lipid membrane.
This article was published in PLOS Pathogens, in June 2022 (doi:10.1371/journal.ppat.1010593).
Title: “Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses”
Authors: Tomokazu Tamura, Shiho Torii, Kentaro Kajiwara, Itsuki Anzai, Yoichiro Fujioka, Kisho
Noda, Shuhei Taguwa, Yuhei Morioka, Rigel Suzuki, Yuzy Fauzyah, Chikako Ono, Yusuke Ohba,
Masato Okada, Takasuke Fukuhara, Yoshiharu Matsuura

Staff
Chikako ONO (Specially Appointed Assoc. Prof. )Shuhei TAGUWA (Specially Appointed Assoc. Prof. )Saya NAKAGOMI (Specially Appointed Assoc. Prof.,
Research Institute for Microbial Diseases)
Kentaro UEMURA (Specially Appointed Assis. Prof. )20

21

DIVISION OF MICROBIOLOGY AND
IMMUNOLOGYmRNA vaccine and drug development
finally in full swing

CLINICAL BIOTECHNOLOGY TEAM
mRNA is a new drug modality that was first commercialized as a novel coronavirus
vaccine. It can be produced by any protein, regardless of the target cell, and is expected to be used for rapid vaccine development against emerging infectious diseases,
personalized vaccines applied to cancer immunotherapy, and disease prevention andtreatment by directly controlling the function of cells in vivo. Our laboratory will pursue
mRNA drug discovery that contributes to improving people's quality of life by setting awide range of themes from functional mRNA design, DDS development, and analysis of
drug eﬃcacy mechanisms.

We have been pursuing the potential of mRNA medicines for the treatment ofvarious diseases, mainly in the fields of intractable diseases of the central
nervous system and regenerative medicine of bone and cartilage. In particular,mRNA medicine for cartilage degenerative diseases are being prepared forclinical trials, which would be the first development of a therapeutic mRNA
medicine in Japan.
Based on our experience and knowledge of mRNA medicine development, we
will promote vaccine development and infectious disease research, in cooperation with experts in immunology and biology related to infectious diseases.

Team Leader

Keiji ITAKA
AKA
Prof.
After graduati
graduating
ating from the University of Tokyo
Faculty of Medicine
Medicine in March 1991, he worke
workedorthopedic
Memorial
as an orththopedic surgeon at Mitsui MemoriaalHospital
al and other hospitals. After working as
aan assistantasssistant professor at The University ofoTokyoo Hospital in 1997, he entered Graduat
te
GraduateScho
ool of Medicine of The University of Tokyo iinnSchool199
1999,
99, where
whe
he began research on DDS iinncollaboration
on with Department of Engineeringg.
Engineering.
After Ph.D. acquisition
tion in 2003, he worked ononDDS, gene therapy, and nucleic
nucle acid medicinemedicine(mRNA medicine) developmentt as lecturer andandassociated professor at The University
sity of Tokyo
o.
Tokyo.
In April 2017, he became a professor at Institut
Ins teInstituteof Biomaterials and Bioengineering, Toky
Tok
yo
Tokyo
Medical and Dental University. In August 2022,
222,
he also became a professor at Center for
Infectious Diseases Education and Research(CiDER), Osaka University.

Staff
Yooksil SIN (Specially Appointed Researcher )22

23

CROSS-DEPARTMENTAL "INFECTIOUS DISEASES"RESEARCH PROMOTION PROGRAM

ALL OSAKA UNIVERSITY RESEARCH PROJECTOUTLINE"The “Team Osaka University Project” was launched in July 2020 to promote research and development oncoronavirus disease 2019 (COVID-19) across specialties and departments on Osaka University. In April
2022, Cross-Departmental "Infectious Diseases" Research Promotion Program was started to promoteinterdisciplinary research which was expected to establish new basic research fields through the whole
university and 37 projects were adopted. Furthermore, in 2023, we aim to achieve CiDER's vision of “To
become a hub for infectious disease education and research”, widely inviting research in the humanities
and social sciences and further promoting fusion research with the natural sciences.

01 Antibody feedback contributes to the development of
01 Omicron-reactive memory B cells
In contrast to a second dose of the SARS-CoV-2 mRNA
vaccine, a third dose elicits potent neutralizing activity
against the Omicron variant. Researchers showed thatpre-generated antibodies modulate the selection of GC andsubsequent memory B cells after the second vaccine dose,
accumulating more Omicronreactive memory B cells overtime, which contributes to the generation of Omicron-neutralizing antibodies elicited by the third vaccine dose.
（Inoue T, et al. Journal of Experimental Medicine. 2022.）

Persistence of COVID-19 vaccine efficacy in patients
02 with immune diseases
Patients with autoimmune diseases are at high risk of
COVID-19, but the medium-term eﬀects of immunosuppression on vaccine eﬃcacy are unknown.
Researchers analyzed immune dynamics after vaccination
against COVID-19 in patients with autoimmune diseases.
They revealed some immunosuppressive therapies attenuate neutralizing antibodies against the virus.
（Yamaguchi Y, et al. The Lancet Regional Health - Western
Pacific. 2022.）

24

Investigating the plasma to predict COVID-19
03 progression
The presence of particular proteins in the plasma, the liquidcomponent of blood, may signal the presence of a disease orindicate the severity of a condition. Now, researchers haveuncovered several key plasma proteins that are related tosevere COVID-19. Researchers used an immunoassay
technique to evaluate expression of five candidate proteins ina validation cohort which was composed of Japanese patientswith severe COVID-19. Levels of four of the candidate
proteins, WFDC2, GDF15, CHI3L1, and KRT19, were significantly higher in COVID-19 patients compared with healthy
controls and were more frequently elevated in non-survivors
than in survivors. The identified proteins may have the potential to serve as biomarkers to predict prognosis
in patients with COVID-19. In the future, rapid diagnostic kits to identify patients at risk of severe COVID-19 are
expected to be applied in the clinic.
（Ebihara T, et al. Journal of Clinical Immunology. 2022.）

04 Efflux pump inhibitors: Bulking up to beat bacteria
Many conventional antibiotics work by making their way
into a bacterial cell. By pumping antibiotics out of the cellusing an eﬄux pump, the bacterium can protect itself fromthem. Researchers have produced new insights into thestructure of a particular bacterial protein known as an eﬄux
pump. This protein is involved in antibiotic resistance andits structure influences the ability of drugs to target it. This
work will inform the rational design of drugs that target
eﬄux pumps, helping them to eliminate drug-resistantbacteria in the future.
（Yamasaki S, et al. Antimicrobial Agents and Chemotherapy.
2022.）

A blood vessel protein reduces mortality in infectious
05 disease
The vascular system plays an essential role in carrying
oxygen and nutrients throughout the body, but too muchvascular permeability, or space between the cells lining theblood vessels, can have devastating results. Researchers
have demonstrated the potential of endothelial cell-specificprotein Roundabout4 (Robo4) as a therapeutic target to
reduce mortality resulting from severe infection. The
research team’s findings may aid in the development ofpreventative or therapeutic drugs to reduce the mortality
rate of severe infectious diseases, such as COVID-19.
（Morita M, et al. Proceedings of the National Academy of
Sciences. 2023.）

25

outline
We educate medical professionals and those who will become medical professionals on the latest technology and knowledge of infectious disease control andtesting, and cultivate future infectious disease control leaders and researchersdeveloping new testing technology. We support healthcare workers to acquire thelatest skills related to infection diseases. We will foster diverse human resources
by preparing various educational contents. We will promptly and flexibly respondto required medical needs, and provide medical human resource education thatis required at each time.

DIVISION OF FOSTERINGREQUIRED MEDICAL HUMAN RESOURCES
SPECIMEN ANALYSIS TEAM
INFECTION CONTROL TEAMMEDICAL INFORMATICS TEAMDivisional Director

Eiichi MORIIProf. ,
Graduate School of Medicine

26

1

2

27

DIVISION OF FOSTERING REQUIRED MEDICALHUMAN RESOURCESINVESTIGATION, FOSTERING, INNOVATIONSPECIMEN ANALYSIS TEAM

Establishment of a specimen management system for
infectious diseases

Technologies such as sample collection and testing are advancing day by day, and new
medical equipment and medical technology are being introduced to the field everyday. Under these circumstances, we will develop human resources who can build new
sample collection methods, test methods, and sample analysis systems.

In collaboration with the Department of Pathology, Osaka University Hospital, ourteam has been collecting clinical specimens related to infectious diseases andconstructing a specimen management system. Currently, we have collected a total of
113 clinical specimens, including colorectal tumors, uterine tumors, and lung tissue
containing pathogens. Using these specimens, we are verifying the specimen management program in actual operation.

Events for medical professionals
On February 19, 2023, we held a "Seminar on Infectious Diseases and Microbiology
for Clinical Laboratory Technicians" to educate 76 clinical laboratory technicians on
clinical microbiology through lectures and workshops.

Team Leader

Creation of educational contents

Shigeto HAMAGUCHIThe Human Resource Development Division is making a concerted eﬀort to create
educational contents. Our Team creates and edits videos for CORE-ID. We have also
created four videos by members of the team, and have built a system that allows us
to complete everything from content recording to editing, uploading, and analysis ofviewing status.

Endowed Chair Assoc. Prof.,
Graduate School of Medicine
Graduated from Jichi Medical University. After
engaging in remote medical care, I have been
conducting clinical and basic research on
infectious diseases and infection control at
Infection Control and Prevention Department in
Osaka University Hospital.
My main research themes are the mechanismof pneumonia and transmission mode causedby Streptococcus pneumoniae and drug-resistant bacteria, and the establishment of a novel
pathogen detection system.

Staff
Yuichi MOTOYAMA(Endowed Chair Assis. Prof. ,Graduate School of
Medicine )Yumi KATAYAMA(Specially Appointed Researcher, Graduate Schoolof Medicine )Yuriko TANAKA(Specially Appointed Researcher, Graduate School

28

Development of new pathogen detection systems
In collaboration with the Institute of Scientific and Industrial Research, our team hasdeveloped an innovative technology to electronically detect and identify individual
pathogen particles, thereby establishing a highly accurate testing method using
saliva specimens from COVID-19 patients. This technology is expected to simplify
immediate diagnosis and screening tests in clinical settings. The research results
have been published in Nature Communications.
The AI nanopore technology has been developed for high-speed and accurate identification by combining nanopores that can measure each virus particle by electric
current and AI that learns the current waveforms of the nanopores. The AI nanopore
technology has also succeeded in discriminating cultured novel coronaviruses andinfluenza A viruses with 90% sensitivity and 96% specificity. AI nanopore can also
rapidly construct new pathogen detection methods by learning diﬀerent pathogens
through AI, and we believe that AI nanopore can quickly respond to emerging infectious diseases that may occur in the future.

29

DIVISION OF FOSTERING REQUIRED MEDICALHUMAN RESOURCESFOSTERING HUMAN RESOURCES, ROOTEDIN THE COMMUNITY AND CONTRIBUTE TO
THE WORLD

INFECTION CONTROL TEAM

We have provided infectious disease-related educational
products to a variety of learners, both online and onsite.

There is a shortage of personnel specializing in infectious disease countermeasuresand infection control, and there is an urgent need to educate healthcare professionals
on the latest techniques and knowledge of infectious diseases and to train future
leaders in infectious disease control. It is also important to educate not only healthcare
professionals but also the general public about infectious disease control. Our mission
is to train physicians, pharmacists, and other medical personnel who will contribute toinfectious disease control and to educate the general public about infectious diseases.

Team Leader

Ryuichi SADA
Endowed Chair Assoc. Prof.,
Graduate School of Medicine
He graduated the Osaka-city university. Afterthe training of junior resident and seniorresident in Saku general hosital, I have been
worked at Tenri hospital and Kameda medical
center as a clinician-educator. In April 2022, I
transfered to the Department of Transformative Protection to Infectious Disease, Osaka
University Graduate School of Medicine. We
have been and will continue to be involved in
pre- and post-graduate medical education, casereporting in clinical settings, and clinicalresearch on diagnosis, treatment and management of infectious diseases.
Board Certified Fellow of the Japanese Association for Infectious Diseases
Board Certified Fellow of The Japan Collage of
Rheumatology
Board Certified Fellow/trainer of The JapaneseSociety of Internal Medicine

Staff
Shungo YAMAMOTO(Endowed Chair Assoc. Prof. ,Graduate School of
Medicine )Go YAMAMOTO(Endowed Senior Lecturer., Graduate Schoolof Medicine )Eisuke KURODA(SEndowed Assist. Prof. , Graduate Schoolof Medicine )301) Sponsored events supported by CiDER
The following seminars were held with the goal of building a foundation for infectious diseasecare and training clinicians who aspire to become infectious disease physicians, and eachprovided education to a lot of participants.
Date

Title

Aim

2022.7.31

Osaka Summer Seminar on

Training of clinicians aspiring to become infectious disease

Infectious Diseases 2022

doctors in Kansai and human exchange

IDATEN Interactive Case

Providing education related to practice-based infectious

2022.9.17
2022.12.10
2023.1.28
2023.2.25

Conference

disease treatment

IDATEN Online Seminar

Providing basic education on infectious disease care

IDATEN Clinical

Providing practice-based education on infectious disease

Conference

care

Career planning seminar for

Presenting future career plans to physicians who want toinfectious disease physicians

become infectious disease physicians2) Creation of infectious disease-related educational content for medical professionals
・CiDER-EDU: We built CiDER-EDU as an educational content delivery platform forlearning correct knowledge about infectious disease practice. Our team provided 6 videos.
・Kutsu-Juku: The team provided two lectures to provide knowledge for writing casereports about infectious diseases.
・Free account stock videos: We provided 9 lectures that were open to those who had not
yet registered for CiDER-EDU.
3) Creation of educational content for the public: We created content to provide infectious
disease-related information to the public, mainly using platforms such as YouTube and
CareNet.
・Kutsu-Oh Cider: https://www.cider.osaka-u.ac.jp/plus-cider/category/くつ王サイダー/・FNN Prime Online "Consultation room with a great doctor" Early diagnosis and treatment ofsepsis. https://www.cider.osaka-u.ac.jp/plus-cider/2023-01-13-sada-ryuichi/
・CareNeTV "Disease Bar 2": https://carenetv.carenet.com/series.php?series_id=4744) On-campus lectures for students: A total of 49 lectures on infectious diseases were given to
Osaka University students.
5) Internal and external lectures: Seminars on infectious diseases were held for initialresidents.
Nine lectures titled "Antimicrobial Drug Seminar" were given for the postgraduate year 1 and2 at Osaka University Hospital.
20 Lectures lectures titled " Tenri Infectious diseases Seminar (TENIS)" were given for the
postgraduate year 1 and 2 at Tenri Hospital.
31

DIVISION OF FOSTERING REQUIRED MEDICALHUMAN RESOURCESINFORMATION, FOSTERING, INNOVATIONMEDICAL INFORMATICS TEAM

Infectious Disease Education Practices

It is necessary to analyze the sample quickly for infectious disease control, but it is also
very important to link the sample with medical information. Therefore, we aim to develop human resources who can build a new advanced medical information system thatcan respond to emerging infectious diseases that are expected to occur one after
another, and to become a hub for medical information education both in Japan andoverseas. In addition, we will develop an educational web content platform thatprovides correct medical information about infectious diseases, aiming provide a learning environment where anyone, anywhere, anytime can learn the appropriate information about infectious diseases.

Team Leader

Toshihiro TAKEDADA
Prof.,
Graduate School of Medicine
M
After graduating from Osaka University Schoolof Medicine, he worked as a cardiologist andconducted basic research in cardiology at thegraduate school. After graduation, he participated in a project to implement paperlesselectronic medical records at the Departmentof Medical Informatics, Osaka University
Hospital. Since then, he has been involved in awide range of clinical, research, and educational
activities in the field of medical informatics andhas been involved in teaching younger
researchers
throughvariousacademic
activities, including serving as a board memberof the Japan Society for Medical Informatics. He
is also involved in government policies related
to medical information as a member of therevision task force for the "Guidelines for the
Safe Management of Medical Information
Systems" of the Ministry of Health, Labour andWelfare and as a member of the "Study Groupfor the Development of Infrastructure for theUtilization of Real World Data Research."

We launched "CiDER-EDU" in April 2022 and had over 3,200
registered accounts by February 2023. We have published 57
pieces of educational content for the training of medical personnel, which a total of 27,000 users have accessed. Physicians,
pharmacists, clinical technologists, nurses, and other professionals are registered on CiDER-EDU, contributing to updating
infectious disease knowledge among all healthcare professionals and developing future leaders who will play a key role in
infectious disease control.

2

Verification of Sample Management Program
We used pathology specimens to demonstrate the Sample
Management Program's ability to link to medical information.
We verified the linkage to medical information by establishing
our sample management program linked to the Clinical Data
Collecting System (CDCS) introduced in OCR-Net (Osaka ClinicalResearch Network), a network centered in Kansai that aims topromote high-quality clinical trials and clinical research. In thissystem, the same subject ID is linked to the medical information in the CDCS and the ID of the collected specimens (clinicalsample ID), which are consolidated in the data center. Therefore, we expect to enable centralized management of medical
and sample information.
In this verification, we confirmed that we can individuallyregister pathology specimens (including infectious diseases)
with their sampling sites and tissue diagnoses from electronic
medical record terminals and that specimens can be linked toclinical information and displayed in a list from the sample
management program. We scheduled one hundred thirteen
specimens in total to register in FY2022. Through this verification trial, we will clarify the issues related to the registration
process and aim to increase the number of specimens
registered in the next fiscal year.

Staff
Shiro MANABE(Endowed Chair Assoc. Prof. ,Graduate School of Medicine )Shoya WADA
(Endowed Chair Assis. Prof. ,32

33

PUBLICATIONS【 Division of Scientiﬁc Information and Public Policy 】

Kotera,Michio Murakami,Tianchen Zhao,Masaharu Tsubokura, Mortality risk associated with nuclear disasters
depends on the time during and following evacuation of hospitals near nuclear power plants: An observational andqualitative study, International Journal of Disaster Risk Reduction, 85, 103514, 2023

Sun Youn Lee,Shusaku Sasaki,Hirofumi Kurokawa,Fumio Ohtake, The school education, ritual customs, andMichio Murakami,Kai Hiraishi,Mei Yamagata,Daisuke Nakanishi,Asako Miura, Belief in just deserts regarding

reciprocity associated with self-regulating hand hygiene practices during COVID-19 in Japan, BMC Public Health,individuals infected with COVID-19 in Japan and its associations with demographic factors and infection-related

22, 1, 2022

and socio-psychological characteristics: a cross-sectional study, PeerJ, 10, e14545, 2022

Yumi Shimizu,Kei Hirai,Yutaka Ueda,Asami Yagi,Fumio Ohtake, Impact of the Threat of COVID-19 Infections on

Michio Murakami,Shuhei Nomura, Annual prevalence of non-communicable diseases and identiﬁcation of

the Perceived Risk to HPV Vaccination., Vaccines, 10, 5, 2022

vulnerable populations following the Fukushima disaster and COVID-19 pandemic, International Journal of Disaster

Tomoharu Mori,Hirofumi Kurokawa,Fumio Ohtake, Labor Supply Reaction to Wage Cuts and Tax Increases: A

Risk Reduction, 84, 103471, 2023

Real-Eﬀort Experiment, FinanzArchiv, Online First, 1, 1, 2022

Manae Uchibori,Cyrus Ghaznavi,Michio Murakami,Akifumi Eguchi,Hiroyuki Kunishima,Satoshi Kaneko,Keiko

Yukari Yamada,Tomoe Uchida,Shusaku Sasaki,Masataka Taguri,Takayuki Shiose,Tatsuyoshi Ikenoue,Shingo

Maruyama-Sakurai,Hiroaki Miyata,Shuhei Nomura, Preventive Behaviors and Information Sources during COVID-

Fukuma, Nudge-Based Interventions on Health Promotion Activity Among Very Old People: A Pragmatic, 2-Arm,

19 Pandemic: A Cross-Sectional Study in Japan, International journal of environmental research and public health,Participant-Blinded Randomized Controlled Trial, Journal of the American Medical Directors Association,

19, 2, 14511, 2022

Forthcoming, 2022

Takashi Azuma,Michio Murakami,Yuki Sonoda,Akihiko Ozaki,Tetsuya Hayashi, Occurrence and Quantitative

Takanori Ida,Takunori Ishihara,Koichiro Ito,Daido Kido,Toru Kitagawa,Shosei Sakaguchi,Shusaku Sasaki, Choosing

Microbial Risk Assessment of Methicillin-Resistant Staphylococcus aureus (MRSA) in a Sub-Catchment of the

Who Chooses: Selection-Driven Targeting in Energy Rebate Programs, National Bureau of Economic Research

Yodo River Basin, Japan, Antibiotics, 11, 10, 1355, 1355, 2022

Working Paper, 30469, 1, 49, 2022

Masaaki Kitajima,Michio Murakami,Syun-suke Kadoya,Hiroki Ando,Tomohiro Kuroita,Hiroyuki Katayama,Seiya

Sun Youn Lee,Shusaku Sasaki,Hirofumi Kurokawa,Fumio Ohtake, The school education, ritual customs, andImoto, Association of SARS-CoV-2 Load in Wastewater With Reported COVID-19 Cases in the Tokyo 2020 Olympic

reciprocity associated with self-regulating hand hygiene practices during COVID-19 in Japan, BMC Public Health,and Paralympic Village From July to September 2021, JAMA Network Open, 5, 8, e2226822, e2226822, 2022

22, 1663, 2022

Michio Murakami,Tsukasa Fujita,Pinqi Li,Seiya Imoto,Tetsuo Yasutaka, Development of a COVID-19 risk

Mei Yamagata & Asako Miura, Retrospective bias during the COVID-19 pandemic, THE JAPANESE JOURNAL OF

assessment model for participants at outdoor music festivals: evaluation of the validity and control measure

EXPERIMENTAL SOCIAL PSYCHOLOGY, Early view, 2023, https://doi.org/10.2130/jjesp.si5-2

eﬀectiveness based on two actual events in Japan and Spain, PeerJ, 10, e13846, e13846, 2022

Michio Murakami, Kai Hiraishi, Mei Yamagata, Daisuke Nakanishi, & Asako Miura, Belief in just deserts regarding

Ryo Iwamoto,Kiyoshi Yamaguchi,Chisato Arakawa,Hiroki Ando,Eiji Haramoto,Ken-ichi Setsukinai,Kotoe

individuals infected with COVID-19 in Japan and its associations with demographic factors and infection-related

Katayama,Takuya Yamagishi,Sumire Sorano,Michio Murakami,Shigeru Kyuwa,Hiroyuki Kobayashi,Satoshi

and socio-psychological characteristics: a cross-sectional study, PeerJ, 10, e14545, 2022,

Okabe,Seiya Imoto,Masaaki Kitajima, The detectability and removal eﬃciency of SARS-CoV-2 in a large-scale

https://doi.org/10.7717/peerj.14545

septic tank of a COVID-19 quarantine facility in Japan, Science of The Total Environment, 849, 157869, 157869,

Daiichi Morii, Asako Miura, & Masashi Komori,The impact of television on-air time on hand hygiene compliance2022

behaviors during COVID-19 outbreak,American Journal of Infection Control,In Press, Journal Pre-

Mizuki Wada,Yoshitake Takebayashi,Michio Murakami, Role of Values and Resilience in Well-Being amongproof,2023,https://doi.org/10.1016/j.ajic.2023.03.001

Individuals Aﬀected by the Fukushima Disaster, Applied Research in Quality of Life, 2022

Flavio Azevedo et al., Social and moral psychology of COVID-19 across 69 countries , Nature Scientiﬁc Data,

Shuhei Nomura,Akifumi Eguchi,Daisuke Yoneoka,Michio Murakami,Cyrus Ghaznavi,Stuart Gilmour,Satoshi

Accepted, 2023, https://psyarxiv.com/a3562/

Kaneko,Takayuki Kawashima,Hiroyuki Kunishima,Wataru Naito,Haruka Sakamoto,Keiko Maruyama-Sakurai,Arata

Shimizu. Y., Hirai. K., Yagi. A., & Ohtake. F, Impact of the Threat of COVID-19 Infections on the Perceived Risk to

Takahashi,Yoshihiro Takayama,Yuta Tanoue,Yoshiko Yamamoto,Tetsuo Yasutaka,Hiroaki Miyata, Characterising

HPV Vaccination., Vaccines, 10, 5, 829, 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147999/

reasons for reversals of COVID-19 vaccination hesitancy among Japanese people: One-year follow-up survey, The

Y. Lyu, T. Doi, T. Hatsuda, Y. Ikeda, J. Meng, K. Sasaki, T. Sugiura, Attractive N-phi interaction and two-pion tailLancet Regional Health - Western Paciﬁc, 100541, 100541, 2022

from lattice QCD near physical point, Physical Review D, 106, 7, 2022
Yoichi Ikeda,Kenji Sasaki,Takashi Nakano, A New Compartment Model of COVID-19 Transmission: The BrokenLink Model., International journal of environmental research and public health, 19, 11, 2022
Kenji Sasaki,Yoichi Ikeda,Takashi Nakano, The Eﬀects of Behavioral Restrictions on the Spread of COVID-19,
Reports, 5, 4, 37, 2022
Michio Murakami,Hitoshi Sato,Tomoko Irie,Masashi Kamo,Wataru Naito,Tetsuo Yasutaka,Seiya Imoto, Sensitivityof rapid antigen tests for COVID-19 during the Omicron variant outbreak among players and staﬀ members of theJapan Professional Football League and clubs: a retrospective observational study, BMJ Open, 13, e067591, 2023
Hiroki Ando,Michio Murakami,Warish Ahmed,Ryo Iwamoto,Satoshi Okabe,Masaaki Kitajima, Wastewater-based
prediction of COVID-19 cases using a highly sensitive SARS-CoV-2 RNA detection method combined withmathematical modeling, Environment International, 107743, 2023

34

Toyoaki Sawano,Yuki Senoo,Saori Nonaka,Akihiko Ozaki,Yoshitaka Nishikawa,Arinobu Hori,Yasuhiro

Cyrus Ghaznavi,Daisuke Yoneoka,Takayuki Kawashima,Akifumi Eguchi,Michio Murakami,Stuart Gilmour,Satoshi
Kaneko,Hiroyuki Kunishima,Wataru Naito,Haruka Sakamoto,Keiko Maruyama-Sakurai,Arata Takahashi,Yoshihiro
Takayama,Yuta Tanoue,Yoshiko Yamamoto,Tetsuo Yasutaka,Hiroaki Miyata,Shuhei Nomura, Factors associatedwith reversals of COVID-19 vaccination willingness: Results from two longitudinal, national surveys in Japan 20212022, The Lancet Regional Health - Western Paciﬁc, 100540, 100540, 2022
Michio Murakami, Re-examining the importance of mask-wearing at mass gathering events, The Lancet Regional
Health - Europe, 18, 100423, 100423, 2022
Motohiro Tsuboi,Toyoaki Sawano,Saori Nonaka,Arinobu Hori,Akihiko Ozaki,Yoshitaka Nishikawa,Tianchen
Zhao,Michio Murakami,Masaharu Tsubokura, Disaster-related deaths after the Fukushima Daiichi nuclear power
plant accident - Deﬁnition of the term and lessons learned, Environmental Advances, 8, 100248, 100248, 2022

35

Momo Takada #,Kosuke Shirai #,Michio Murakami *,Susumu Ohnuma *,Jun Nakatani,Kazuo Yamada,Masahiro

Yuta Yamaguchi,Yasuhiro Kato,Ryuya Edahiro,Jonas N Søndergaard,Teruaki Murakami,Saori Amiya,Shinichiro

Osako,Tetsuo Yasutaka: #, * These authors contributed equally to this work, Important factors for public

Nameki,Yuko Yoshimine,Takayoshi Morita,Yusuke Takeshima,Shuhei Sakakibara,Yoko Naito,Daisuke

acceptance of the ﬁnal disposal of contaminated soil and wastes resulting from the Fukushima Daiichi nuclear

Motooka,Yu-Chen Liu,Yuya Shirai,Yasutaka Okita,Jun Fujimoto,Haruhiko Hirata,Yoshito Takeda,James B

power station accident, PLOS ONE, 17, 6, e0269702, e0269702, 2022

Wing,Daisuke Okuzaki,Yukinori Okada,Atsushi Kumanogoh, Consecutive BNT162b2 mRNA vaccination induces

Megumi Adachi,Michio Murakami,Daisuke Yoneoka,Takayuki Kawashima,Masahiro Hashizume,Haruka

Kensuke Shibata,Chihiro Motozono,Masamichi Nagae,Takashi Shimizu,Eri Ishikawa,Daisuke Motooka,Daisuke

Sakamoto,Akifumi Eguchi,Cyrus Ghaznavi,Stuart Gilmour,Satoshi Kaneko,Hiroyuki Kunishima,Keiko Maruyama-

Okuzaki,Yoshihiro Izumi,Masatomo Takahashi,Nao Fujimori,James B Wing,Takahide Hayano,Yoshiyuki

Sakurai,Yuta Tanoue,Yoshiko Yamamoto,Hiroaki Miyata,Shuhei Nomura, Factors associated with the risk

Asai,Takeshi Bamba,Yoshihiro Ogawa,Makoto Furutani-Seiki,Mutsunori Shirai,Sho Yamasaki, Symbiotic bacteria-

perception of COVID-19 infection and severe illness: A cross-sectional study in Japan, SSM - Population Health,dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b., Nature

18, 101105, 101105, 2022

Namkoong, H., Edahiro, R., Takano, T.,... Wing.B.J, Kumanogoh.A,Okada.Y., et al. DOCK2 is involved in the host

Munehito Machida,Michio Murakami,Aya Goto, Diﬀerences in Data Trustworthiness and Risk Perception between

genetics and biology of severe COVID-19. Nature 609, 754‒760 (2022). https://doi.org/10.1038/s41586-022-

Bar Graphs and Pictograms, International Journal of Environmental Research and Public Health, 19, 8, 4690, 4690,

Takuya Koike, Kentaro Fujii, Kohei Kometani, Noah S Butler, Kenji Funakoshi, Shinya Yari, Junichi Kikuta, Masaru

2022

Ishii, Tomohiro Kurosaki, Wataru Ise, Progressive diﬀerentiation toward the long-lived plasma cell compartment inMichio Murakami, Masaaki Kitajima, Noriko Endo, Warish Ahmed, Bernd Gawlik: The growing need to establish a

the bone marrow. , The Journal of experimental medicine, 220, 2, e20221717, 2023

global wastewater surveillance consortium for future pandemic preparedness, Journal of Travel Medicine, taad035,

Kota Itahashi,Takuma Irie,Junichiro Yuda,Shogo Kumagai,Tokiyoshi Tanegashima,Yi-Tzu Lin,Sho

2023

Watanabe,Yasushi Goto,Jun Suzuki,Keiju Aokage,Masahiro Tsuboi,Yosuke Minami,Genichiro Ishii,Yuichiro

Tetsuo Yasutaka, Masaki Onishi, Wataru Naito, Yoshiaki Bando, Tomoaki Okuda, Michio Murakami: Maximum

Ohe,Wataru Ise,Tomohiro Kurosaki,Yutaka Suzuki,Shohei Koyama,Hiroyoshi Nishikawa, BATF epigenetically andproportion of masks worn: Collaborative eﬀorts in Japanese professional football, Journal of Infection and Public

transcriptionally controls the activation program of regulatory T cells in human tumors., Science immunology, 7,

Health, 2023

Nagoya A, Sada R, Kimura H, Yamamoto H, Morishita K, Miyoshi E, Morii E, Shintani Y, and Kikuchi A., CKAP4 is a

Luna Kinoshita, Aya Goto, Satoko Okabe, Kenichi Satoh, Kaori Honda, Kimiko Ueda, Michio Murakami, Kenneth E.

potential exosomal biomarker and a therapeutic target for lung cancer., Trans. Lung Cancer Res. 2023, doi:

Nollet: Daily meals in context: A quantitative analysis of elementary school students' drawings. Frontiers in
Communication, 8, 1008108, 2023.
Akira Yoneshiro, Yoshitake Takebayashi, Michio Murakami: The association between music preferences and wellbeing after the Fukushima disaster: A cross sectional study, Disaster Medicine and Public Health Preparedness,
2023
Fujita M,Hatta T,Ide K, Current status of cell-based
interventions in Japan., Cell Stem Cell., 29, 9, 1294, 1297, 2022
1
Honjo Y,Ide K,Takechi H, Day service use and improved serial 7 and verbal ﬂuency scores in patients with
Alzheimerʼs disease., Psychogeriatrics., 22, 5, 659, 665, 2022
Hatta T,Ide K,Misao F,Ikka T, Financial risks posed by unproven stem cell interventions: Estimation of refunds
from medical expense deductions in Japan., Stem Cell Rep., 17, 5, 1016, 1018, 2022
Honjo Y,Ide K,Takechi H, Most families tend to realize progress of Alzheimerʼs disease when behavioral andpsychological symptoms are obvious., Psychogeriatrics., 22, 3, 317, 323, 2022

10.21037/tlcr-22-571
Masako Kohyama,Tatsuya Suzuki,Wataru Nakai,Chikako Ono,Sumiko Matsuoka,Koichi Iwatani,Yafei Liu,Yusuke
Sakai,Atsushi Nakagawa,Keisuke Tomii,Koichiro Ohmura,Masato Okada,Yoshiharu Matsuura,Shiro
Ohshima,Yusuke Maeda,Toru Okamoto,Hisashi Arase, SARS-CoV-2 ORF8 is a viral cytokine regulating immune
Shojiro Haji,Taiki Ito,Carla Guenther,Miyako Nakano,Takashi Shimizu,Daiki Mori,Yasunori Chiba,Masato
Tanaka,Sushil K Mishra,Janet A Willment,Gordon D Brown,Masamichi Nagae,Sho Yamasaki, Human Dectin-1 isO-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2., eLife, 11, 2022
He Zhang,Yumi Itoh,Tatsuya Suzuki,Kan-Ichiro Ihara,Tomohisa Tanaka,Saori Haga,Hajime Enatsu,Maho
Yumiya,Mari Kimura,Akira Takada,Daiki Itoh,Yuri Shibazaki,Shuto Nakao,Sachiyo Yoshio,Kei Miyakawa,Yuki
Miyamoto,Hanae Sasaki,Tadahiro Kajita,Masaya Sugiyama,Masashi Mizokami,Taro Tachibana,Akihide Ryo,Kohji
Moriishi,Eiji Miyoshi,Tatsuya Kanto,Toru Okamoto,Yoshiharu Matsuura, Establishment of monoclonal antibodies
Hiroki Hayashi,Jiao Sun,Yuka Yanagida,Takako Otera,Ritsuko Kubota-Koketsu,Tatsuo Shioda,Chikako
Ono,Yoshiharu Matsuura,Hisashi Arase,Shota Yoshida,Ryo Nakamaru,Nan Ju,Ryoko Ide,Akiko Tenma,Sotaro
Kawabata,Takako Ehara,Makoto Sakaguchi,Hideki Tomioka,Munehisa Shimamura,Sachiko Okamoto,Yasunori

Division of Microbiology and Immunology

36

Amaishi,Hideto Chono,Junichi Mineno,Takao Komatsuno,Yoshimi Saito,Hiromi Rakugi,Ryuichi Morishita,Hironori

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami,

Nakagami, Preclinical study of a DNA vaccine targeting SARS-CoV-2., Current research in translational medicine,

Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Shimon Sakaguchi, Atsushi

Ryotaro Nouda,Takahiro Kawagishi,Yuta Kanai,Masayuki Shimojima,Masayuki Saijo,Yoshiharu Matsuura,Takeshi

Kumanogoh, Yukinori Okada, James Badger Wing, A sex-biased imbalance between Tfr, Tph, and atypical B cells

Kobayashi, The nonstructural p17 protein of a fusogenic bat-borne reovirus regulates viral replication in virus

determines antibody responses in COVID-19 patients., Proceedings of the National Academy of Sciences, 120, 4,

species- and host-speciﬁc manners., PLoS pathogens, 18, 6, e1010553, 2022, doi:10.1371/journal.ppat.1010553

Takehito Yokoi, Mari Murakami, Takako Kihara, Shigeto Seno, Mitsuru Arase, James Badger Wing, Jonas Nørskov

Tomokazu Tamura,Shiho Torii,Kentaro Kajiwara,Itsuki Anzai,Yoichiro Fujioka,Kisho Noda,Shuhei Taguwa,Yuhei

Søndergaard, Ryuichi Kuwahara, Tomohiro Minagawa, Eri Oguro-Igashira, Daisuke Motooka, Daisuke Okuzaki,

Morioka,Rigel Suzuki,Yuzy Fauzyah,Chikako Ono,Yusuke Ohba,Masato Okada,Takasuke Fukuhara,Yoshiharu

Ryota Mori, Atsuyo Ikeda, Yuki Sekido, Takahiro Amano, Hideki Iijima, Keiichi Ozono, Tsunekazu Mizushima,

Matsuura, Secretory glycoprotein NS1 plays a crucial role in the particle formation of ﬂaviviruses., PLoS

Seiichi Hirota, Hiroki Ikeuchi, Kiyoshi Takeda, Identiﬁcation of a unique subset of tissue-resident memory CD4+ T

Hitoshi Kawasuji,Yoshitomo Morinaga,Hideki Tani,Yumiko Saga,Makito Kaneda,Yushi Murai,Akitoshi Ueno,Yuki

Kiyoshi Minohara, Masaki Imai, Takuma Matoba, James Badger Wing, Hiroaki Shime, Mizuyu Odanaka, Ryuta

Miyajima,Yasutaka Fukui,Kentaro Nagaoka,Chikako Ono,Yoshiharu Matsuura,Hideki Niimi,Yoshihiro Yamamoto,

Uraki, Daisuke Kawakita, Tatsuya Toyama, Satoru Takahashi, Akimichi Morita, Shingo Murakami, NaganariEﬀectiveness of the third dose of BNT162b2 vaccine on neutralizing Omicron variant in the Japanese population,

Ohkura, Shimon Sakaguchi, Shinichi Iwasaki, Sayuri Yamazaki, Mature dendritic cells enriched in regulatory

Journal of Infection and Chemotherapy, 28, 9, 1273, 1278, 2022, doi:10.1016/j.jiac.2022.05.009

37

Ryota Maeda,Junso Fujita,Yoshinobu Konishi,Yasuhiro Kazuma,Hiroyuki Yamazaki,Itsuki Anzai,Tokiko

Takeshi Inoue,Ryo Shinnakasu,Chie Kawai,Hiromi Yamamoto,Shuhei Sakakibara,Chikako Ono,Yumi Itoh,Tommy

Watanabe,Keishi Yamaguchi,Kazuki Kasai,Kayoko Nagata,Yutaro Yamaoka,Kei Miyakawa,Akihide Ryo,Kotaro

Terooatea,Kazuo Yamashita,Toru Okamoto,Noritaka Hashii,Akiko Ishii-Watabe,Noah S Butler,Yoshiharu

Shirakawa,Kei Sato,Fumiaki Makino,Yoshiharu Matsuura,Tsuyoshi Inoue,Akihiro Imura,Keiichi Namba,Akifumi

Matsuura,Hisatake Matsumoto,Shinya Otsuka,Kei Hiraoka,Takanori Teshima,Masaaki Murakami,Tomohiro

Takaori-Kondo, A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants

Kurosaki, Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in

Chihiro Okada,Etsuko Ikeda-Ishizaka,Chikako Ono,Yoshiharu Matsuura,Hikaru Sonoda, Establishment of

Junso Fujita,Fumiaki Makino,Haruyasu Asahara,Maiko Moriguchi,Shota Kumano,Itsuki Anzai,Jun-Ichi

Neutralizing Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 by the Screening

Kishikawa,Yoshiharu Matsuura,Takayuki Kato,Keiichi Namba,Tsuyoshi Inoue, Epoxidized graphene grid for highlywith Exosomes Expressing the Viral Spike Protein., Monoclonal antibodies in immunodiagnosis andeﬃcient high-resolution cryoEM structural analysis., Scientiﬁc reports, 13, 1, 2279, 2279, 2023,

Tomoyuki Nishikawa,Chin Yang Chang,Jiayu A Tai,Hiroki Hayashi,Jiao Sun,Shiho Torii,Chikako Ono,Yoshiharu

Rina Hashimoto,Junya Takahashi,Keisuke Shirakura,Risa Funatsu,Kaori Kosugi,Sayaka Deguchi,Masaki

Matsuura,Ryoko Ide,Junichi Mineno,Miwa Sasai,Masahiro Yamamoto,Hironori Nakagami,Kunihiko Yamashita,
Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.,
Hitoshi Kawasuji,Yoshitomo Morinaga,Hideki Tani,Yumiko Saga,Makito Kaneda,Yushi Murai,Akitoshi Ueno,Yuki
Miyajima,Yasutaka Fukui,Kentaro Nagaoka,Chikako Ono,Yoshiharu Matsuura,Hideki Niimi,Yoshihiro Yamamoto,Eﬀectiveness of the third dose of BNT162b2 vaccine on neutralizing Omicron variant in the Japanese population.,
Journal of infection and chemotherapy : oﬃcial journal of the Japan Society of Chemotherapy, 28, 9, 1273, 1278,
Masako Kohyama,Tatsuya Suzuki,Wataru Nakai,Chikako Ono,Sumiko Matsuoka,Koichi Iwatani,Yafei Liu,Yusuke
Sakai,Atsushi Nakagawa,Keisuke Tomii,Koichiro Ohmura,Masato Okada,Yoshiharu Matsuura,Shiro
Ohshima,Yusuke Maeda,Toru Okamoto,Hisashi Arase, SARS-CoV-2 ORF8 is a viral cytokine regulating immune
Rina Hashimoto,Junya Takahashi,Keisuke Shirakura,Risa Funatsu,Kaori Kosugi,Sayaka Deguchi,Masaki
Yamamoto,Yugo Tsunoda,Maaya Morita,Kosuke Muraoka,Masato Tanaka,Tomoaki Kanbara,Shota
Tanaka,Shigeyuki Tamiya,Nagisa Tokunoh,Atsushi Kawai,Masahito Ikawa,Chikako Ono,Keisuke Tachibana,Masuo
Kondoh,Masanori Obana,Yoshiharu Matsuura,Akihiro Ohsumi,Takeshi Noda,Takuya Yamamoto,Yasuo
Yoshioka,Yu-Suke Torisawa,Hiroshi Date,Yasushi Fujio,Miki Nagao,Kazuo Takayama,Yoshiaki Okada, SARS-CoVAtsushi Yamanaka,Pimploy Rattanaamnuaychai,Mami Matsuda,Ryosuke Suzuki,Yoshiharu Matsuura,Masashi
Tatsumi,Eiji Konishi, Engineered ﬂavivirus vaccines control induction of crossreactive infection-enhancing and neutralizing antibodies., Vaccine, 40, 42, 6004, 6011, 2022, doi:10.1016/j.vaccine.2022.09.012
Maya Shofa,Tomotaka Okamura,Emiko Urano,Yoshiharu Matsuura,Yasuhiro Yasutomi,Akatsuki Saito, RepeatedIntravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge,
International Journal of Molecular Sciences, 23, 22, 14002, 2022, doi:10.3390/ijms232214002
Yoshitaka Isaka,Taku Yoshiya,Chikako Ono,Akinori Uchiyama,Haruhiko Hirata,Shigeto Hamaguchi,Satoshi
Kutsuna,Yoshitsugu Takabatake,Ryotaro Saita,Tomomi Yamada,Atsushi Takahashi,Masaya Yamato,Yukie
Nohara,Shugo Tsuda,Itsuki Anzai,Tomonori Kimura,Yoshito Takeda,Kazunori Tomono,Yoshiharu Matsuura,
Establishment and clinical application of SARS-CoV-2 catch column., Clinical and experimental nephrology, 1, 9,
Yoshio Mori,Masafumi Sakata,Shota Sakai,Toru Okamoto,Yuichiro Nakatsu,Shuhei Taguwa,Noriyuki
Otsuki,Yusuke Maeda,Kentaro Hanada,Yoshiharu Matsuura,Makoto Takeda, Membrane Sphingomyelin in Host
Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry.,
Akiho Yoshida,Shinya Okamura,Shiho Torii,Sayuri Komatsu,Paola Miyazato,Hitomi Sasaki,Shiori Ueno,HidehikoSuzuki,Wataru Kamitani,Chikako Ono,Yoshiharu Matsuura,Shiro Takekawa,Koichi Yamanishi,Hirotaka Ebina,
Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity.,38

Yamamoto,Yugo Tsunoda,Maaya Morita,Kosuke Muraoka,Masato Tanaka,Tomoaki Kanbara,Shota
Tanaka,Shigeyuki Tamiya,Nagisa Tokunoh,Atsushi Kawai,Masahito Ikawa,Chikako Ono,Keisuke Tachibana,Masuo
Kondoh,Masanori Obana,Yoshiharu Matsuura,Akihiro Ohsumi,Takeshi Noda,Takuya Yamamoto,Yasuo
Yoshioka,Yu-Suke Torisawa,Hiroshi Date,Yasushi Fujio,Miki Nagao,Kazuo Takayama,Yoshiaki Okada, SARS-CoVMei Hashizume,Ayako Takashima,Chikako Ono,Toru Okamoto,Masaharu Iwasaki, Phenothiazines inhibit SARSCoV-2 cell entry via a blockade of spike protein binding to neuropilin-1, Antiviral Research, 209, 105481, 2023,
Hao Shao,Shuhei Taguwa,Luke Gilbert,Arielle Shkedi,Sara Sannino,Christopher J Guerriero,Zachary J GaleDay,Zapporah T Young,Jeﬀrey L Brodsky,Jonathan Weissman,Jason E Gestwicki,Judith Frydman, A campaign
targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biologicalMichihito Sasaki,Koshiro Tabata,Mai Kishimoto,Yukari Itakura,Hiroko Kobayashi,Takuma Ariizumi,Kentaro
Uemura,Shinsuke Toba,Shinji Kusakabe,Yuki Maruyama,Shun Iida,Noriko Nakajima,Tadaki Suzuki,Shinpei
Yoshida,Haruaki Nobori,Takao Sanaki,Teruhisa Kato,Takao Shishido,William W Hall,Yasuko Orba,AkihikoSato,Hirofumi Sawa, S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates
Kittiya Intaruck,Yukari Itakura,Mai Kishimoto,Herman M Chambaro,Agus Setiyono,Ekowati Handharyani,Kentaro
Uemura,Hayato Harima,Satoshi Taniguchi,Masayuki Saijo,Takashi Kimura,Yasuko Orba,Hirofumi Sawa,Michihito
Sasaki, Isolation and characterization of an orthoreovirus from Indonesian fruit bats., Virology, 575, 10, 19, 2022,
Shinsuke Toba,Akihiko Sato,Makoto Kawai,Yoshiyuki Taoda,Yuto Unoh,Shinji Kusakabe,Haruaki Nobori,Shota
Uehara,Kentaro Uemura,Keiichi Taniguchi,Masanori Kobayashi,Takeshi Noshi,Ryu Yoshida,Akira Naito,Takao
Shishido,Junki Maruyama,Slobodan Paessler,Michael J Carr,William W Hall,Kumiko Yoshimatsu,Jiro
Arikawa,Keita Matsuno,Yoshihiro Sakoda,Michihito Sasaki,Yasuko Orba,Hirofumi Sawa,Hiroshi Kida, Identiﬁcationof cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses., Proceedings of the
Yoshifumi Kusumoto,Kyohei Hayashi,Soichiro Sato,Toru Yamada,Iori Kozono,Zenzaburo Nakata,Naoya
Asada,Shungo Mitsuki,Ayahisa Watanabe,Chiaki Wakasa-Morimoto,Kentaro Uemura,Shuhei Arita,Shinobu
Miki,Tohru Mizutare,Hidenori Mikamiyama, Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease
Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization, ACS Medicinal Chemistry Letters, 13, 10, 1634, 1641,
Koshiro Tabata,Yukari Itakura,Shinsuke Toba,Kentaro Uemura,Mai Kishimoto,Michihito Sasaki,Jessica J
Harrison,Akihiko Sato,William W Hall,Roy A Hall,Hirofumi Sawa,Yasuko Orba, Serological characterization of
lineage II insect-speciﬁc ﬂaviviruses compared with pathogenic mosquito-borne ﬂaviviruses., Biochemical andHaruaki Nobori,Keita Fukao,Takayuki Kuroda,Naomi Anan,Ryoichi Tashima,Masaaki Nakashima,Sayuri
Noda,Minako Tajiri,Mikinori Torii,Shinsuke Toba,Kentaro Uemura,Takao Sanaki,Takao Shishido,Yuki
Tachibana,Teruhisa Kato, Eﬃcacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model., The

Ryota Otsubo,Takeharu Minamitani,Kouji Kobiyama,Junso Fujita,Toshihiro Ito,Shiori Ueno,Itsuki Anzai,Hiroki

Yuto Unoh,Shota Uehara,Kenji Nakahara,Haruaki Nobori,Yukiko Yamatsu,Shiho Yamamoto,Yuki

Tanino,Hiroshi Aoyama,Yoshiharu Matsuura,Keiichi Namba,Ken-Ichi Imadome,Ken J Ishii,Kouhei Tsumoto,Wataru

Maruyama,Yoshiyuki Taoda,Koji Kasamatsu,Takahiro Suto,Kensuke Kouki,Atsufumi Nakahashi,Sho

Kamitani,Teruhito Yasui, Human antibody recognition and neutralization mode on the NTD and RBD domains of

Kawashima,Takao Sanaki,Shinsuke Toba,Kentaro Uemura,Tohru Mizutare,Shigeru Ando,Michihito Sasaki,Yasuko

SARS-CoV-2 spike protein., Scientiﬁc reports, 12, 1, 20120, 20120, 2022, doi:10.1038/s41598-022-24730-4

Orba,Hirofumi Sawa,Akihiko Sato,Takafumi Sato,Teruhisa Kato,Yuki Tachibana, Discovery of S-217622, a

Maaya Morita,Aki Yoneda,Nagisa Tokunoh,Tatsumi Masaki,Keisuke Shirakura,Mayumi Kinoshita,Rina

Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19., Journal of

Hashimoto,Naoya Shigesada,Junya Takahashi,Masashi Tachibana,Shota Tanaka,Masanori Obana,Nobumasa

Eiichi Kojima,Atsuhiro Iimuro,Mado Nakajima,Hirotaka Kinuta,Naoya Asada,Yusuke Sako,ZenzaburoHino,Masahito Ikawa,Kazutake Tsujikawa,Chikako Ono,Yoshiharu Matsuura,Hiroyasu Kidoya,Nobuyuki

Nakata,Kentaro Uemura,Shuhei Arita,Shinobu Miki,Chiaki Wakasa-Morimoto,Yuki Tachibana, Pocket-to-Lead:

Takakura,Yoshiaki Kubota,Takefumi Doi,Kazuo Takayama,Yasuo Yoshioka,Yasushi Fujio,Yoshiaki Okada,

Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in

as a Template., Journal of medicinal chemistry, 65, 8, 6157, 6170, 2022, doi:10.1021/acs.jmedchem.1c02217

39

Motoki Nakamura,Kentaro Uemura,Noriko Saito-Tarashima,Akihiko Sato,Yasuko Orba,Hirofumi Sawa,Akira

Nomoto, Hidetoshi, Ishikane, Masahiro, Nakamoto, Takato, Ohta, Masayuki, Morioka, Shinichiro, Yamamoto, Kei, .

Matsuda,Katsumi Maenaka,Noriaki Minakawa, Synthesis and Anti-dengue Virus Activity of 5-Ethynylimidazole-4-. . Ohmagari, Norio. , Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large

carboxamide (EICA) Nucleotide Prodrugs, Chemical and Pharmaceutical Bulletin, 70, 3, 220, 225, 2022,

outbreaks, 2012-2013 and 2018-2019 (vol 15, e0231966, 2020). , PLOS ONE, 17, 8
Kutsuna, Satoshi. , COVID-19 clinical picture in the elderly. , Geriatric Medicine, 95, 101, 2022

Division of Fostering Required Medical Human Resources

Kutsuna, Satoshi, Ohbe, Hiroyuki, Matsui, Hiroki, & Yasunaga, Hideo. , Delayed Tetracycline Initiation Increases
Mortality Risk in Patients With Japanese Spotted Fever: Retrospective Analysis Using a National Inpatient

Tomita, Noriko, Saito, Sho, Terada-Hirashima, Junko, Mikami, Ayako, Uemura, Yukari, Kutsuna, Satoshi, . . .

Database., Paper presented at the Open Forum Infectious Diseases, 2022

Terada, Mari. , A Multi-Center, Open-Label, Randomized Controlled Trial to Evaluate the Eﬃcacy of Convalescent

Suzuki, Tetsuya, Asai, Yusuke, Ide, Satoshi, Fukuda, Saori, Tanaka, Akihito, Shimanishi, Yumiko, . . . Sato,

Plasma Therapy for Coronavirus Disease 2019: A Trial Protocol (COVIPLA-RCT). , Life, 12, 6, 856, 2022

Mitsuhiro. , Factors associated with high antibody titer following coronavirus disease among 581 convalescent

Hirofumi Motobayashi, Shougen Sumiyoshi, Kazuaki Aoki, Aoi Yogo, Kentaro Tochitani, Shungo Yamamoto,plasma donors: A single-center cross-sectional study in Japan. , Journal of Infection and Chemotherapy, 28, 2, 206,

Tsunehiro Shimizu, Tetsushi Mizuno, Masaharu Tokoro, A case of amebic colitis and liver abscesses that occurred

Nomoto, Hidetoshi, Ishikane, Masahiro, Gu, Yoshiaki, Yamamuro, Ryosuke, Osawa, Ryosuke, Hosokawa, Naoto, . .

after treatment of coronavirus disease 2019 with dexamethasone., IDCases, 31, e01648, 2023

. Sekiya, Noritaka. , Nationwide Descriptive Epidemiological Study of Patients with COVID-19 Evacuated from

Maeki, Takahiro, Tajima, Shigeru, Ando, Naokatsu, Wakimoto, Yuji, Hayakawa, Kayoko, Kutsuna, Satoshi, . . . Lim,

Wuhan, China to Japan from January to February, 2020. , Japanese Journal of Infectious Diseases , 76, 1, 20, 26,

Chang-Kweng., Analysis of cross-reactivity among ﬂaviviruses using sera of patients with dengue showed the

Saito, Sho, Thao, Pham Thi Ngoc, Ishikane, Masahiro, Xuan, Phan Thi, Kutsuna, Satoshi, Dai, Huynh Quang, . . .

importance of neutralization tests with paired serum samples for the correct interpretations of serological test

Shimada, Yasuyuki. , Physical oral care prevents ventilator-associated pneumonia in Vietnam: A prospective

Inada, Makoto, Ishikane, Masahiro, Terada, Mari, Matsunaga, Akihiro, Maeda, Kenji, Iwamoto, Noriko, . . .

interventional study., Journal of Infection and Chemotherapy, 28, 12, 1632, 1638, 2022

Ishizaka, Yukihito. , Antibody responses after two doses of SARS-CoV-2 mRNA-1273 vaccine in an individual with

Kawashima, Akira, Kutsuna, Satoshi, Shimomura, Akira, Sato, Lubna, Ando, Honami, Tanikawa, Tsutomu, . . .

history of COVID-19 re-infection., International Journal of Infectious Diseases, , 119, 18, 20, 2022

Ohmagari, Norio. , Streptobacillus notomytis Bacteremia after Exposure to Rat Feces. , Emerging Infectious

Akihiro Shiroshita, Shungo Yamamoto, Keisuke Anan, Hokuto Suzuki, Masafumi Takeshita, Yuki Kataoka,

Matsushita, Yumi, Yokoyama, Tetsuji, Hayakawa, Kayoko, Matsunaga, Nobuaki, Ohtsu, Hiroshi, Saito, Sho, . . .

Association Between Empirical Anti-Pseudomonal Antibiotics for Recurrent Lower Respiratory Tract Infections andKutsuna, Satoshi. , We should pay more attention to sex diﬀerences to predict the risk of severe COVID-19: men

Mortality: A Retrospective Cohort Study., International journal of chronic obstructive pulmonary disease, 17, 2919,

have the same risk of worse prognosis as women more than 10 years older. , Journal of epidemiology , 33, 1, 38,

Aya Katasako, Sho Sasaki, Yoshihiko Raita, Shungo Yamamoto, Kentaro Tochitani, Minoru Murakami, Ryo

Okamoto, Kana, Harada, Taku, Kosaka, Shintaro, & Kutsuna, Satoshi. , Deprescribing antacids after the diagnosis

Nishioka, Kiichiro Fujisaki, Association between serum alkaline phosphatase and bacteraemia in haemodialysisof Clostridioides diﬃcile infection: A single-center observational study., Journal of Infection and Chemotherapy,

outpatients: a multicentre retrospective cross-sectional study., BMJ open, 12, 10, e058666, 2022

Kutsuna, Satoshi, Ohbe, Hiroyuki, Matsui, Hiroki, & Yasunaga, Hideo. , Eﬀectiveness of ﬂuoroquinolone

Tanaka, Ippei, Kutsuna, Satoshi, Ohkusu, Misako, Kato, Tomoyuki, Miyashita, Mari, Moriya, Ataru, & Ohkusu,

antimicrobials in addition to tetracyclines for Japanese spotted fever: A retrospective analysis using a national

Kiyofumi. , Bacillus subtilis variant natto Bacteremia of Gastrointestinal Origin, Japan. Emerging Infectious

inpatient database., International Journal of Infectious Diseases, 123, 70, 75, 2022

Hiroi, Yukio, Ohtsu, Hiroshi, Uemura, Yukari, Hayakawa, Kayoko, Asai, Yusuke, Kutsuna, Satoshi, . . . Ohmagari,Morioka, S, Tsuzuki, S, Maruki, T, Terada, M, Miyazato, Y, Kutsuna, S, . . . Sanada, M. , Epidemiology of post-

Norio. , Cardiovascular complications of hospitalized patients with coronavirus disease 2019 in a Japanese registry

COVID conditions beyond 1 year: a cross-sectional study. , Public Health, 216, 39, 44, 2023

Kawashima, Akira, Kutsuna, Satoshi, Shimomura, Akira, Suzuki, Tetsuya, Nakamoto, Takato, Ando, Honami, . . .

Isaka Y, Yoshiya T, Ono C, Uchiyama A, Hirata H, Hamaguchi S, Kutsuna S, Takabatake Y, Saita R, Yamada T,

Ohmagari, Norio. , Catheter-related bloodstream infection caused by Tsukamurella ocularis: A case report.,

Takahashi A, Yamato M, Nohara Y, Tsuda S, Anzai I, Kimura T, Takeda Y, Tomono K, Matsuura Y., Establishment

Nakatani, Natsuki, Miyazaki, Ryoichi, Nagata, Yasutoshi, Nozato, Toshihiro, Ashikaga, Takashi, & Kutsuna,and clinical application of SARS-CoV-2 catch column., Clin Exp Nephrol. , 7, 1, 9, 2022

Satoshi. , Cervical Spine Osteomyelitis Caused by Campylobacter jejuni Without Gastrointestinal Symptoms. , The

Ishikane, Masahiro, Unoki-Kubota, Hiroyuki, Moriya, Ataru, Kutsuna, Satoshi, Ando, Honami, Kaburagi, Yasushi, . .

Komaki-Yasuda, Kanako, Kutsuna, Satoshi, Kawaguchi, Miki, Kamei, Mina, Uchihashi, Kinya, Nakamura, Keiji, . . .

. Ohmagari, Norio. , Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 panel, a rapid multiplex PCR method for

Kano, Shigeyuki. , Clinical performance testing of the automated haematology analyzer XN-31 prototype using

the diagnosis of COVID-19., Journal of Infection and Chemotherapy, 28, 6, 729, 734, 2022

whole blood samples from patients with imported malaria in Japan., Malaria Journal, 21, 1, 1, 13, 2022

Miyazato, Yusuke, Tsuzuki, Shinya, Morioka, Shinichiro, Terada, Mari, Kutsuna, Satoshi, Saito, Sho, . . . Akashi,

Tomidokoro, Daiki, Asai, Yusuke, Hayakawa, Kayoko, Kutsuna, Satoshi, Terada, Mari, Sugiura, Wataru, . . . Hiroi,

Masako. , Factors associated with development and persistence of post-COVID conditions: A cross-sectional

Yukio. , Comparison of the clinical characteristics and outcomes of Japanese patients with COVID-19 treated in

Morioka, Shinichiro, Tan, Ban Hock, Kikuchi, Hiroe, Asai, Yusuke, Suzuki, Tetsuya, Ashida, Shinobu, . . . Tan,

primary, secondary, and tertiary care facilities. , Journal of Infection and Chemotherapy, 29, 3, 302, 308, 2023

Thuan Tong. , Factors associated with prolonged psychological distress among nurses and physicians engaged in

Suzuki, Tetsuya, Morioka, Shinichiro, Kikuchi, Tatsuya, Sato, Lubna, Nomoto, Hidetoshi, Yamamoto, Kei, . . .

COVID-19 patient care in Singapore and Japan. , Frontiers in Psychiatry, 13, 2022

Ohmagari, Norio. , Case Report: Leptospirosis by Wild Rat Bite in Winter in Tokyo Metropolitan Area, Japan. , The

Nomoto, Hidetoshi, Asai, Yusuke, Hayakawa, Kayoko, Matsunaga, Nobuaki, Kutsuna, Satoshi, Kodama, Eiichi N, &American journal of tropical medicine and hygiene, 107, 1, 100, 101, 2022

Ohmagari, Norio. , Impact of the COVID-19 pandemic on racial and ethnic minorities in Japan. , Epidemiology &Yamamoto, Kei, Asai, Yusuke, Nakatani, Issaku, Hayashi, Kenichi, Nakagawa, Hidenori, Shinohara, Koh, . . .

Ando, Naokatsu, Kutsuna, Satoshi, Takaya, Saho, Katanami, Yuichi, & Ohmagari, Norio. , Imported African Tick

Shimono, Nobuyuki. , Characteristics and potential quality indicators for evaluating pre-travel consultations in

Bite Fever in Japan: A Literature Review and Report of Three Cases., Internal Medicine, 61, 7, 1093, 1098, 2022

Japan hospitals: the Japan Pretravel consultation registry (J-PRECOR). Tropical Diseases, , Travel Medicine andHayama, Hiromasa, Ide, Satoshi, Kitami, Yui, Hara, Hisao, Kutsuna, Satoshi, & Hiroi, Yukio. , Interleukin-6 is

Yoshioka N, Deguchi M, Hagiya H, Kagita M, Tsukamoto H, Takao M, Yoshida H, Hamaguchi S, Maeda I, Hidaka

upregulated and may be associated with myocardial injury in some patients who have recovered from COVID-19. ,Y, Tomono K., Comparison of extraction-based and elution-based polymerase chain reaction testing, andUeno, Mikako, Iwata-Yoshikawa, Naoko, Matsunaga, Akihiro, Okamura, Tadashi, Saito, Sho, Ashida, Shinobu, . . .

automated and rapid antigen testing for the diagnosis of severe acute respiratory syndrome coronavirus 2, J Med

Yaoita, Yuu. , Isolation of human monoclonal antibodies with neutralizing activity to a broad spectrum of SARSCoV-2 viruses including the Omicron variants. , Antiviral Research, 201, 105297, 2022

40

41

Tsuchiya, Kiyoto, Maeda, Kenji, Matsuda, Kouki, Takamatsu, Yuki, Kinoshita, Noriko, Kutsuna, Satoshi, . . . Oka,

Yicheng Wang,Anant K Menon,Yuta Maki,Yi-Shi Liu,Yugo Iwasaki,Morihisa Fujita,Paula A Guerrero,Daniel Varó'n

Shinichi. , Neutralization activity of IgG antibody in COVID-19-convalescent plasma against SARS-CoV-2 variants. ,Silva,Peter H Seeberger,Yoshiko Murakami,Taroh Kinoshita, Genome-wide CRISPR screen reveals CLPTM1L as a

Nakagami H, Hayashi H, Sun J, Yanagida Y, Otera T, Nakagami F, Hamaguchi S, Yoshida H, Okuno H, Yoshida S,

lipid scramblase required for eﬃcient glycosylphosphatidylinositol biosynthesis., Proceedings of the National

Nakamaru R, Yokoyama S, Fujimoto T, Hongyo K, Akeda Y, Morishita R, Tomono K, Rakugi H., Phase I Study to

Academy of Sciences of the United States of America, 119, 14, e2115083119, 2022

Assess the Safety and Immunogenicity of an Intradermal COVID-19 DNA Vaccine Administered Using a Pyro-Drive

Fujii S, Ishibashi T, Kokura M, Fujimoto T, Matsumoto S, Shidara S, Kurppa KJ, Pape J, Caton J, Morgan PR,

Inada, Makoto, Togano, Tomiteru, Terada, Mari, Shiratori, Katsuyuki, Tsuzuki, Shinya, Takamatsu, Yuki, . . .

Heikinheimo K, Kikuchi A, Jimi E, Kiyoshima T., RAF1-MEK/ERK pathway-dependent ARL4C expression promotes

Kutsuna, Satoshi. , Preserved SARS-CoV-2 neutralizing IgG activity of in-house manufactured COVID-19

ameloblastoma cell proliferation and osteoclast formation, J. Pathol., 256, 1, 119, 133, 2022

Inoue, Kenji, Kobayashi, Seiichi, Sato, Keigo, Kanno, Hitoshi, Kantou, Rina, Naganuma, Yuka, . . . Yanai, Masaru. ,Iguchi K, Sada R, Matsumoto S, Kimura H, Zen Y, Akita M, Gon H, Fukumoto T, Kikuchi A., The DKK1-CKAP4

Regional antimicrobial stewardship program in a provincial medical zone in Japan: A multifaceted approach.,signal axis promotes hepatocellular carcinoma aggressiveness. , Cancer Sci., doi: 10.1111/cas.15743., 2023

Japanese Journal of Infectious Diseases, 75, 4, 347, 354, 2022

Nagoya A, Sada R, Kimura H, Yamamoto H, Morishita K, Miyoshi E, Morii E, Shintani Y, and Kikuchi A., CKAP4 is a

Aoi Yogo, Shougen Sumiyoshi, Kazuaki Aoki, Hirofumi Motobayashi, Kentaro Tochitani, Shungo Yamamoto,potential exosomal biomarker and a therapeutic target for lung cancer., Trans. Lung Cancer Res., in press, 2023

Tsunehiro Shimizu, Report of HKU-1 coronavirus nosocomial cluster in a city hospital in Japan during thecoronavirus disease 2019 (COVID-19) pandemic., Antimicrobial stewardship & healthcare epidemiology, 3, 1, e18,
Noguchi T, Tachibana K, Inoue T, Sakai T, Tsujikawa K, Fujio Y, Yamagishi Y, Hamaguchi S, Kutsuna S, Kondoh
M., Safety evaluation of MA-T after ingestion in mice., Toxicology., 477, 153254, 2022
Kutsuna, Satoshi, Saito, Sho, Takamatsu, Yuki, Terada, Mari, Togano, Tomiteru, Kinoshita, Noriko, . . .
Matsubayashi, Keiji. , Safety of convalescent plasma therapy for COVID-19 patients and analysis of viral kinetics: asingle-center, open-label, single-arm, interventional study in Japan., GHM Open, 2, 1, 38, 43, 2022
Matsushita, Yumi, Yokoyama, Tetsuji, Hayakawa, Kayoko, Matsunaga, Nobuaki, Ohtsu, Hiroshi, Saito, Sho, . . .
Kutsuna, Satoshi. , Smoking and severe illness in hospitalized COVID-19 patients in Japan. , International Journal
Kutsuna, Satoshi, Ohbe, Hiroyuki, Matsui, Hiroki, & Yasunaga, Hideo., Steroid pulse therapy for severe fever withthrombocytopenia syndrome patients may not improve prognosis: Retrospective analysis with overlap weighting
using a national inpatient database. , Journal of Infection and Chemotherapy, 2023
Takahata, Hanako, Onishi, Kazunari, Nomoto, Hidetoshi, Iwamoto, Noriko, Hayashi, Kuniyoshi, Hori, Narumi, . . .
Ohmagari, Norio. , Surveillance and risk assessment of health screening for vaccine-preventable diseases amonginternational students in Japan: A cross-sectional study in 2020., Human Vaccines & Immunotherapeutics, 18, 6,
Kazuaki Aoki, Shungo Yamamoto, Kentaro Tochitani, Transient Large-vessel Vasculitis after Covid-19 mRNA
Vaccination., Internal medicine (Tokyo, Japan), 61, 13, 2083, 2084, 2022
Aoi Yogo, Shungo Yamamoto, Shougen Sumiyoshi, Nobuki Iwamoto, Kazuaki Aoki, Hirofumi Motobayashi, Kentaro
Tochitani, Tsunehiro Shimizu, Takaya Murashima, Nobuyuki Nishikawa, Takehiko Segawa, Two cases ofpyelonephritis with bacteremia by Staphylococcus epidermidis in male patients with nephrolithiasis: Case reports

Planning and Management Oﬃce etc.
Natsuki Shichinohe,Daisuke Kobayashi,Ayaka Izumi,Kazuya Hatanaka,Rio Fujita,Taroh Kinoshita,Norimitsu
Inoue,Naoya Hamaue,Keiji Wada,Yoshiko Murakami, Sequential hydrolysis of FAD by ecto-5' nucleotidase CD73
and alkaline phosphatase is required for uptake of vitamin B2 into cells., The Journal of biological chemistry,
Tetsuya Hirata,Jing Yang,Seita Tomida,Yuko Tokoro,Taroh Kinoshita,Morihisa Fujita,Yasuhiko Kizuka, ER entry
pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal
GPI-attachment sequence., The Journal of biological chemistry, 298, 10, 102444, 102444, 2022
Smrithi Salian,Xin-Yu Guo,Yoshiko Murakami,Taroh Kinoshita,Parneet Kaur,Anju Shukla,Katta M Girisha,Morihisa
Fujita,Philippe M Campeau, C18orf32 loss-of-function is associated with a neurodevelopmental disorder withhypotonia and contractures., Human genetics, 141, 8, 1423, 1429, 2022
Mizuki Ishida,Yuta Maki,Akinori Ninomiya,Yoko Takada,Philippe Campeau,Taroh Kinoshita,Yoshiko Murakami,
Ethanolamine-phosphate on the second mannose is a preferential bridge for some GPI-anchored proteins., EMBO
Ryoko Kuwayama,Keiichiro Suzuki,Jun Nakamura,Emi Aizawa,Yoshichika Yoshioka,Masahito Ikawa,Shin
Nabatame,Ken-Ichi Inoue,Yoshiari Shimmyo,Keiichi Ozono,Taroh Kinoshita,Yoshiko Murakami, Establishment ofmouse model of inherited PIGO deﬁciency and therapeutic potential of AAV-based gene therapy., Nature

4243