Aaron Del Duca
VP Microbiome Platform
aaron.delduca@daytwo.com
Ottawa, Canada / Tel Aviv, Israel

Cost of diabetes care ~ $250 Billion / year in the USA
Globally, this exceeds $1.3 Trillion
Globally, the number ofpeople living with Diabetes
52%of the adult population issuffering from metabolic disease

21%of the adult population issuffering from metabolic disease

Hast TRIPLED in the last
20 years

Source: KFF analysis of IBM MarketScan Commercial Claims and Encounters Database, 2003-2017
Namekata, T. et al., Epidemiology 4:157. doi:10.4172/2161-1165.1000157

2© 2020, DayTwo

An apple a day….

…isn’t for everyone
3© 2020, DayTwo

Clinical studies prove the AI platform & science
10 years of science

Personalized Nutrition byPrediction of Glycemic
Responses

4

Bread Affects ClinicalParameters and Induces Gut
Microbiome-Associated
Personal Glycemic Responses

Environment Dominates Over
Host Genetics in Shaping
Human Gut Microbiota© 2020, DayTwo

Assessment of Personalized
Nutrition by Prediction ofGlycemic Responses

Model of Personalized
Postprandial Glycemic
Response to Food

DayTwo is adigital
precision medicine
solution formetabolic diseases
that enables a path to remission
5© 2020, DayTwo

The Problem: one size doesn’t fit all
Same oatmeal, different response
Carl

Glucose levels(mg/dl)

160

Mary

160

120

120

80

80

4040

Hours

Hours

Glucose levels(mg/dl)

012

Phil

160

0120

80

80

4040

Hours

6Adapted from Vega-López et al. Diabetes Care 2007

© 2020, DayTwo

012

Brad

160

120

1

Hours
2012

How solve it? We match the right food to each person!
InputsMeasure personal features

Machine LearningDesigns personalized diets tolower glycemic responses

Microbiome

OutputPredict personal glycemic responses

160

7.1

12080
400

Blood tests and CGMs

Hours

2160

6.1

12080
400

Health Questionnaires

Hours

2160

2.9
Anthropometrics

Food Diary

712080400

Glycemic Response
Algorithm© 2020, DayTwo

Hours

2160

8.5

12080
400

Hours

2

The solution:
personalized nutrition
Glucose levels(mg/dl)3.7 7.9

7.9

7.0
3.7

Carl

160
120

12080

80

4040

= Algorithm-Derived
SugarScores™

012

Hours

0Mary160

00212

2

Hours

Glucose levels(mg/dl)7.5
3.9

Phil1601208080

40400
Adapted from Vega-López et al. Diabetes Care 2007

© 2020, DayTwo

1HoursBrad160

120084.1
7.2

2020

1Hours22

The right food balances blood sugar
Glucose levels(mg/dl)

200

150

100

50
9Generic diet© 2020, DayTwo

DayTwo diet

DayTwo Impact & Business Model

A1C Reduction

0.98

10Time-in-Range

62%

WeightEngagement

8 lbs.

of Time Spent < 180 mg/dl

94%

EnergySleep Quality

HungerNPS

56%

36%

54%

88

* Based on multiple clinical studies of people withType 2 Diabetes measured over 3-6 months© 2020, DayTwo

Science/ClinicalAdvisors

Leadership TeamThank You

11Lihi Segal
Co-Founder, CEOEran Segal, PhD
Weizmann InstituteJosh Stevens
President US

Eran Elinav, MD, PhD
Weizmann InstitutePrinciple Investigators &Authors of Cell

Davidi Bachrach
COO

Dariush Mozaffarian, MD
Tufts

Shaul Sharoni
CFO

Ron Krauss, MD
UCSF

Amir Golan
CCO INTL

Rob Knight, PhD
UC San Diego

Nutrition& Cardiology

Jack Gilbert, PhD Melinda Maryniuk, MEd, RD
UC San Diego
Joslin Diabetes Center(Retired)

Gut-MicrobiomeResearch© 2020, DayTwo

Noa Green
VP ProductAaron Del Duca
VP Microbiome

Jan Berger, MD
MBGH

Diabetes Population
Clinical Best Practices

12

Food is more effective in lowering blood sugar
6.00
Placebo

5.95

es
ADA Guidelin

5.90

A1C %

5.80
5.75
5.70
5.65
5.60
0131

23Months

4© 2020, DayTwo

56

Food as medicine

Diabetes Pre
vention Pro
gram

Rx & SOC

Metformin

5.85

The DayTwo solution

Gut Microbiome
Profiling +Questionnaire
1Telehealth & remote patientmonitoring

App + Predictive A.I.
Meal Recommendations2314© 2020, DayTwo