Product portfolio

Regenerative
solutionsnobelbiocare.com

creos™ was launched in2014
creos™ xenoprotect
creos™ allo.gain
creos™ allo.protect

2016
creos™ xenogain
creos™ xenogain collagen2017
creos™ wound dressings(xenoplug, xenocote and xenotape)2021
Cytoplast™ TXT-200
Cytoplast™ Ti-PTFE
creos™ allo.gain in a bowl

2023
Cytoplast™ RTM collagen
Cytoplast™ PTFE sutures and membranes
Resorba® Glycolon™
Pro-Fix™ precision fixation system
Master-Pin-Control hybrid pin system
Cytoplast™ RTM wound dressings
Cytoplast™ MicroDermRegenerative solutions
Nobel Biocare – your trusted regenerative
partner for you and your patients
Indication-based product overview 		

4Bone grafts
creos™ allo.gain 						6creos™ dbm putty					6creos™ xenogain						8creos™ xenogain collagen				8Membranes
creos™ xenoprotect					10Cytoplast™ RTM collagen				12creos™ allo.protect					14Cytoplast™ TXT-200 PTFE				16Cytoplast™ Ti-reinforced PTFE				16Soft tissue matrix
Cytoplast™ MicroDerm					18Wound dressings
Cytoplast™ RTMPlug, RTMFoam and RTMTape		

20

creos™ xenoplug, xenocote and xenotape			

22

Sutures
Cytoplast™ PTFE					24Resorba® Glycolon™					25Fixation and tenting systems
Pro-Fix™ precision fixation system 			26

Master-Pin-Control hybrid pin system			27

Product listing with article numbers		

28

References						36

4Regenerative product portfolio

Indication-based
product overview

Ridge preservation
With
primary closure

Without
primary closure

corticocancellous

0.25 – 1.0 cc

0.25 – 1.0 cc

demineralized cortical

0.25 – 1.0 cc

0.25 – 1.0 cc

mineralized cortical

0.25 – 1.0 cc

0.25 – 1.0 cc

mineralized cancellous

0.25 – 1.0 cc

0.25 – 1.0 cc

min./demin. cortical

0.25 – 1.0 cc

0.25 – 1.0 cc

dbm putty

0.25 – 1.0 cc

0.25 – 1.0 cc

creos xenogain*

0.25 – 0.5 g

0.25 – 0.5 g

creos xenogain + 10% porcine collagen type I

creos xenogain collagen

0.1 – 0.25 g

0.1 – 0.25 g

Resorbable, xenogenic collagen membranecreos xenoprotect

15 x 20 mm

Resorbable, firm collagen membrane

Cytoplast RTM collagen

15 x 20 mm

Resorbable allogenic barrier membranecreos allo.protect

10 x 10 mm
15 x 20 mm

Non-resorbable high-density
PTFE membrane

Cytoplast TXT-200

12 x 24 mm
12 x 30 mm
25 x 30 mm

Non-resorbable titanium-reinforced
high-density PTFE membrane

Cytoplast Ti-PTFE

ANL and AS

See article lists (p. 28–35) for most commonly used product codes.
Note See Instructions For Use for full prescribing information,
including indications, contraindications, warnings and precautions.
Volumes and sizes listed are to be used as approximations
and may vary depending on the defect/patient.
creos allo.gain

Allogenic bone graft substitute

Bone grafts
Xenogenic bone graft substitute

Membranes

Micro-surfaced allogenic
acellular dermal matrix

Cytoplast MicroDerm

MatrixCytoplast RTMPlug,
RTMFoam and RTMTape

Plug (fully intact
sockets only)creos xenoplug, xenocote
and xenotape

Plug (fully intact
sockets only)

Absorbable wound dressing
Wound dressings

Sutures

Fixation systems

Non-absorbable
PTFE suture – monofilament

Cytoplast PTFE

Absorbable
PGA/PCL suture – monofilament

Resorba Glycolon

Titanium fixation pins

Master-Pin-Control
hybrid pin system

Self-drilling titanium
fixation screws

Pro-Fix precision
fixation system*Please consult article lists (p. 28–35) for conversion to volume (cc)All sizes

All sizes

All sizes

Regenerative product portfolio

Horizontal ridge
augmentation

Vertical ridge
augmentation

Peri-implant
defect0.25 – 1.0 cc

Sinus
augmentation

Soft tissue augmentation (aroundteeth or implants)

1.0 – 2.0 cc
0.5 – 1.0 cc

0.25 – 1.0 cc

0.5 – 1.0 cc

0.25 – 1.0 cc

0.25 cc
1.0 – 2.0 cc

0.25 cc

1.0 – 2.0 cc

0.25 – 1.0 cc

0.5 – 1.0 cc

1.0 – 2.0 cc

0.5 – 1.0 cc
0.25 – 0.5 g

Periodontal
defects

0.5 – 2 g

0.25 – 0.5 g

0.25 cc
0.25 cc

0.25 – 0.5 g

1–2g

0.25 g0.1 – 0.25 g

0.25 – 0.5 g

0.1 – 0.25 g

15 x 20 mm
25 x 30 mm

25 x 30 mm
30 x 40 mm

15 x 20 mm

15 x 20 mm
25 x 30 mm

15 x 20 mm

15 x 20 mm
20 x 30 mm

20 x 30 mm
30 x 40 mm

15 x 20 mm

15 x 20 mm
20 x 30 mm

15 x 20 mm

10 x 10 mm
15 x 20 mm

15 x 20 mm
20 x 30 mm

10 x 10 mm
15 x 20 mm

15 x 20 mm
20 x 30 mm

12 x 24 mm
12 x 30 mm
25 x 30 mm
Shapes depending
on defect

Shapes depending
on defect

Shapes depending
on defect
1 x 1 cm1 x 2 cm
1 x 4 cm
2 x 4 cmFoam, Tape(for donor site)
Cote, Tape(for donor site)

All sizes

All sizes

All sizes

All sizes

All sizes

All sizes

All sizes

All sizes

Membranefixation pins

Membranefixation pins

Membranefixation pins

Membranefixation pins

All types

All types

Membranefixation screws

Membranefixation screws

All sizes

5

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Regenerative product portfolio

creos™ allo.gain
A wide range of allograft
materials, because all yourcases are different

Broad allograft
portfolio for different
clinical indications*‒ Mineralized and demineralized‒ Cortical and cancellous‒ Available in a bowl foran easy handlingallo.gain demineralizedbone matrix (dbm) putty‒ 100% pure demineralized allograft with nofiller or inert carrier‒ Syringe type dispenser
for easy application

Ensuring safety and quality levels‒ A proprietary patented process of tissue cleaning and sterilization‒ The tissue bank follows strict processing procedures in order to ensure
safe tissue grafts of the highest quality for transplantation*See Instructions For Use for full prescribing information, including
indications, contraindications, warnings and precautions

Allograft

Regenerative product portfolio

creos™ allo.gain bone particulate:a wide range of options

100 µm / 435x
Mineralized cancellous boneMineralized cortical boneMineralized cancellous bone

Offers a high density bone withparticle size range from 0.125
mm to 1 mm and available
volume of 0.25 cc to 2.0 cc.

A porous structured bone withparticle size range from 0.25
mm to 1 mm and available
volume of 0.25 cc to 2.0 cc.

Mineralized/demineralized
cortical bone

Demineralized cortical bone

Blend of 70% mineralized and
30% demineralized cortical bone.
Mineralized corticocancellous bone

Demineralized high density bonewith particle size range from0.125 mm to 1 mm and available
volume of 0.25 cc to 2.0 cc.

Blend of cortical andcancellous bone produced
from sections of the ilium.

creos™ allo.gain demineralizedbone matrix (dbm) putty
100% pure allograft

Available in three volumes

The creos™ allo.gain dbm putty is
100% pure demineralized allograftwith no filler or inert carrier.

The creos™ allo.gain dbm putty isavailable in three different volumes:
0.5 cc, 1.0 cc and 2.5 cc. This meansthat the required amount can beused with minimal excess material.

100 µm / 85x

Scan the code forclinical resources.

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Regenerative product portfolio

creos™ xenogain

Xenogenic bone graft used for guided boneregeneration and guided tissue regeneration

Three different methods of application:

Vial

Bowl

Syringe

Similar to human bone
‒ Chemical composition: Ca/P ratio‒ Interconnected macropores1,2

Easy handling‒ Homogenous particle size1‒ Hydrophilic for fast rehydration3,4

Solid foundation for dental
implant treatment“I appreciate its handling properties
and I see its high hydrophilicity as a
biological advantage in sinus graftingand peri-implant defect regeneration.”
Dr. Werner Zechner, Austria‒ Osteoconductive properties2‒ Long-term volume stability6‒ Uneventful healing4,6,7,8,9

Bovinecreos™ xenogain collagen
Purified cancellous bovine bone mineral granules and 10%
porcine collagen in block form and syringe. The collagenhelps to hold creos™ xenogain collagen in the desired place.
Especially recommended for extraction socket management.
Block

Syringe

BovinePorcineRegenerative product portfolio

Scaffold for successful
regeneration
Preserved natural features of bone throughoptimized manufacturing process.2

Calcium phosphate ratio
2.0
1.679

1.680

creos™ xenogain

Human bone

1.5

Chemical composition
With a calcium phosphate ratio that reflects thecomposition in human bone and a structure withlow crystallinity, the body accepts creos™ xenogain
as a suitable framework for bone formation.1

1.0
0.5
0.0

Particle size
‒ Homogenous particle size1‒ Maintains space for bone regeneration4
Photographic micrograph of creos™ xenogain and reference productshowing the particle size distribution (magnification 20x)

Preserved nanostructure
Nanostructure preserved thanks to treatment at comparatively low temperature (600°C) and no sintering.2
Macro and micro-structureInterconnected macropores allow cells to
invade bone grafts and micropores contributeto capillary liquid uptake (hydrophilicity).10,11

1.0 mm

1.0 mmcreos™ xenogain(0.2 – 1.0 mm)

Reference product(0.25 – 1.0 mm)

Solid foundation for
implant placement
The graft integrates with the newly formed bone,building a basis for successful implant placement.4

Schematic showing the defect and bone size prior to and after GBR

Histological cross section of the cellular components: new bone (NB),
bone graft (XG). Bone-to-graft-particle contact shown by dashed line.
XG

XG

XG

XG

XG

XG
435x
XG
Initial situation before GBR

8 months post-surgery
XG

In a multicenter clinical study involving 46 patients,
bone increase after 8 months was 4.0 mm (+56.9 %gain) and 4.7 mm (51.0% gain) at 1 and 3 mmfrom the top of the crest, respectively.7

NB

XG

NB

100 µmNB

Histological assessment of the trephinecores showed 37.3 % of new bone, 39.1
% of graft material and 23.6 % of soft
tissue (n = 6 cores, 3 patients).7

GBR led to robust bone regeneration during
the 8 months of healing, enabling successfulplacement of 91 implants in 43 patients, with anaverage insertion torque of 37.8 ± 5.1 Ncm.7
Scan the code formore resources.

910

Regenerative product portfolio

creos™ xenoprotect
Nobel Biocare’s highest selling
resorbable collagen membrane

Easy handling1,2‒ Does not stick to instruments‒ Repositioning in-situ possible‒ Low surface expansion
when hydrated‒ Both sides can face the defectHigh mechanical strength2,3,4‒ High suture retention1,4,9‒ Highly tear-resistantNatural collagen membrane‒ Non-chemically cross-linked14‒ Made from porcine collagen

Facilitates bone gain2,3,5,6,7,8‒ Tested and approved
biocompatibility7,10‒ Beneficial clinical results7,10“What I like is that the handling is veryeasy. The mechanical stability is very
high and when it is rehydrated it adapts
very well to the underlying bone.”Dr. Bastian Wessing, Germany

PorcineRegenerative product portfolio

High mechanical strength
In an in vitro study aiming to compare themechanical strength of commonly used native
non-chemically cross-linked and chemicallycross-linked collagen membranes4‒ creos™ xenoprotect demonstrated thehighest force at break, wet (21.2 N).
‒ creos™ xenoprotect had the highest
suture retention when hydrated (6.1 N).

Provides a physical barrier tocontain the bone graft material
at the defect site1,2,3,5,6,11,12,13
Prevents ingrowth of surrounding tissue for aperiod of time that is long enough to allow boneregeneration to take place.
In an animal model, after 20 weeks, the thicknessof xenoprotect decreased only slightly, whereas
the reference membrane showed a thickness lossof around 50%, confirming the higher stabilityof xenoprotect against biodegradation in vivo.3

Comparison of commercial membranes in a hydrated state30
25

Force atbreak
wet [N]

20
15
10
5

creos™ CO

JS

OF

BG

BE

ML

OP

BM

Sutureretention
wet [N]creos™ CO

JS

OF

BG

BE

ML

OP

BM

Non-cross-linked collagen membranes (NXL) – CX: creos™ xenoprotect[Nobel Biocare]; CO: Copios [Zimmer]; JS: Jason [botiss]; OF: Osseoguard
Flex [3i]; BG: Bio-Gide [Geistlich]

20 weeks

8
7
6
5
4
3
2
1
0

20 weeks

0

Representative histological images at 20
weeks implantation in a rat model.

200 µm200 µmcreos™ xenoprotect

Reference membrane

Cross-linked collagen membranes (XL) – BE: BioMend Extend [Zimmer];
ML: Mem-Lok [BioHorizons]; OP: OssixPlus [Datum Dental]; BM: BioMend[Zimmer];*Statistically significant

Facilitates new bone formation2,3,5,6,7,8
New bone formation (%)

In a randomized controlled clinical trial, 24
patients were treated with creos™ xenoprotect
and 25 with a reference membrane. In thecreos™ xenoprotect group, the defect height
reduced at 6-month re-entry by 81%.

4030

34.9%*

20
15.5%

10
0

creos™
xenoprotect

Reference

In a comparative in vivo study, creos™ xenoprotect
demonstrated significantly higher new boneformation in the central portion of the defect.
This increase in bone formation was associated withsignificantly increased expression of the growth factor
Bmp2, which has a strong role in osteogenesis.7

In the reference membrane group, the defectheight reduced at 6-month re-entry by 62%.5
Schematic showing the defect height prior
to treatment and 6 months after GBR
5.1 ± 2.1 mm

4.9 ± 1.9 mm

creos™ xenoprotect

Reference

1.0 ± 1.3 mm*Statistically significant

creos™ xenoprotect

1.7 ± 2.1 mm

Reference
Scan the code formore resources.

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Regenerative product portfolio

Cytoplast™
RTM collagen

Resorbable, firm and long-lasting
collagen membrane

Optimized flexibility‒ Stiff enough for easy placement,
yet easily drapes over ridge

Long predictable
resorption time
‒ Resorption time 26–38 weeks

High tensile strength‒ Suture or tack the membranein place without tearing

Manufactured from highly purified
Type 1 bovine Achilles tendon
Reconstituted fiber construction allows
tissue integration while preventing
direct passage of epithelial cells

Bovine14

Regenerative product portfolio

creos™ allo.protect
An effective andreliable barrier

allo.protect pericardium
membrane‒ Durable protection

Ensuring safety and quality levels*‒ A proprietary patented process of tissue cleaning and sterilization‒ The tissue bank follows strict processing procedures in order to ensure
safe tissue grafts of the highest quality for transplantation

Allograft*See Instructions For Use for full prescribing information, including
indications, contraindications, warnings and precautions

Regenerative product portfolio

creos™ allo.protect
pericardium membrane
Three sizes
creos™ allo.protect is available in three different sizes:
10 x 10 mm, 15 x 20 mm and 20 x 30 mm.
Easy to handle
Easy to tack and suture with high tear resistance.
Adapts well to surface contours and maintains shapeand size once placed.
Durable protection
Strong and stable due to the pore structure of native
pericardium. Slow degradation for an effective barrier
during the healing process.
Biocompatible and tissue friendly
Preservation of the native pericardium collagen matrix
and its mechanical properties.

2 µm / 10,000x

Its native three-dimensional interconnective structure
gives a longer time to degradation than other collagensources.

Scan the code forclinical resources.

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Regenerative product portfolio

Cytoplast™ PTFE

Non-resorbable dense PTFE membrane
for extraction socket management, ridge
augmentations and grafting of large defects

Cytoplast™
TXT-200
PTFE membrane
Purposely leave themembrane exposed
Preservation of the soft tissue architecture and keratinized mucosa

100% dense (non-expanded) PTFE
Impervious to bacteria – pore size
less than 0.3 µm

Non-resorbable

Soft tissues attaches to, but doesn’t
grow through, the membrane.

Will not resorb prematurely – youdictate healing time

Exposed membrane allows for non-surgicalremoval; no anesthesia required

Synthetic

Cytoplast™
Ti-reinforced
PTFE membrane
Delicate, lightweight framework

Handling options

Easy to trim and compliant withthe overlying soft tissues

Broad portfolio with 15 shapes
in two thicknesses

Less is more

Traditional frame design

Less titanium bulk allows for greater
versatility in shaping and placement,
providing additional stability in large,
non-spacemaking osseous defects

Incorporating delicate and strategically-placed titanium “struts”
with more than 25 years of clinicalhistory and successful use in GBR

Regenerative product portfolio

Unique properties of dense PTFE membranes
Dense PTFE

Expanded PTFE

20 µm

20 µm

SEM image courtesy of Schüpbach Ltd, Switzerland.

SEM image courtesy of Schüpbach Ltd, Switzerland.

Dense PTFE was designed towithstand exposure in the oral
environment, which represents an
improvement to earlier versionsof expanded PTFE in applications
such as ridge preservation where
deliberate membrane exposure
offers several advantages.

Designed to aid in membrane stabilization

200 µmHexagonal surface
dimples provide a
textured surface that
increases the area
available for cellular
attachment without
increasing porosity.
The textured surface isdesigned to help stabilize
the membrane andthe soft tissue flap.

Although PTFE isinherently a non-stickmaterial, cells attach
to the outside of thedense PTFE membranes.
Cellular adhesion isimportant to create aseal around the edgesof exposed dense PTFE
membranes or to support
primary closure in larger
graft applications.

SEM image courtesy of Schüpbach Ltd, Switzerland.

Clinical evidence
Efficacy
Bone loss 1-year post-extraction1

Soft tissue regeneration 90
days post-extraction2

Vertical ridge augmentation around implants3

1.5

100%

6

N=12

5

5.49 mm

1.0

0.5

0

N=15

4

59.68%

3

N=100.25 mm
Verticalbone loss

N=150.30 mmHorizontalbone loss

Vertical bone loss measured at crest. Horizontal
measured from stent to buccal plate.

18.25%
0%

Cytoplast PTFE
membrane

No membrane

Measured as reduction of the occlusal distance
between buccal and lingual gingival margins.

N=11
4.91 mm2
1
0

CytoplastTi-reinforced
PTFE membrane

Expanded PTFE

Mean vertical bone regeneration.

Predictability
In two separate studies treating a total of 696 extraction
sites using dense PTFE membranes in an exposed
technique, there were no reported infections.4,5Scan the code formore resources.

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Regenerative product portfolio

Cytoplast™
MicroDerm

A micro-surfaced allogenic
acellular dermal matrix
Benefits‒ Rapidly hydrates within 60 seconds upon
contact with blood or saline solution‒ Strict tolerances on thickness forconsistent handling and predictability‒ Not side specificTechnical specifications‒ Shelf life of 5 years
Dry‒ Terminally sterilized to a SAL of 10-6
‒ Packaged dry‒ Manufactured using a proprietary series of soaks
and rinses to effectively clean and disinfect thetissue without the use of harsh chemicals‒ Store at room temperature

Indications*‒ Used for repair or replacement ofdamaged or inadequate soft tissue

Hydrated‒ Root coverage‒ Gingival augmentation‒ Soft tissue augmentation around implants

Allograft”The tissue is very easy to handle when applying to your surgery
site and the hydration time is shorter than its competitors. I
believe its strongest clinical characteristic is the immediateadsorption of blood into the MicroDerm graft as you place into
the recipient site. I am very pleased with the results I’m seeing.”
Dr. Reid Lester, United States*See Instructions For Use for full prescribing information, including
indications, contraindications, warnings and precautions

Regenerative product portfolio

Dual-sided micro-cuts
to increase surface area
Micro-cut channels shorten pathwaysfor vascularization and increase tissue
surface area available for attachment.

Cytoplast™ MicroDerm case study
Case photos provided by Shaun Rotenberg, DMD

Pre-op

Day 0

Day 0

MicroDerm placed

Sutured2 weeks post-op

9 weeks post-op“The early healing and soft tissue appearance isreally where MicroDerm shines. Tissue never looks
this good so early on with traditional allograft.”
Dr. Shaun Rotenberg, United States

Available sizes

After hydration

Thickness 1.2 mm +/- 0.2 mm

CMD1010NB
1 x 1 cm, 1/box
CMD1020NB
1 x 2 cm, 1/box
CMD1040NB
1 x 4 cm, 1/box

CMD2040NB
2 x 4 cm, 1/box

Cytoplast™ MicroDermbecomes soft and pliable.

Scan the code formore resources.

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Regenerative product portfolio

Cytoplast™ RTM
wound dressings

Absorbable wound dressings to protect
wound beds and aid in wound healing

Available in 3 shapes and sizes
Made from purified collagen
derived from bovine tissue
Essentially resorbs in 30 days

Plug
1 cm x 2 cm

Applications*‒ Surgical wounds

Foam
2 cm x 4 cm x 3 mm (thick)‒ Periodontal surgical wounds‒ Extraction sites‒ Dental sores‒ Oral ulcers (non-infected or viral)‒ Suture sites‒ Burns

Tape‒ Traumatic wounds

2.5 cm x 7.5 cm x 1 mm (thick)*See Instructions For Use for full prescribing information, including
indications, contraindications, warnings and precautions

BovineRegenerative product portfolio

Scan the code formore resources.

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Regenerative product portfolio

creos™ absorbablecollagen dental
wound dressings
Complementing yourregenerative set

Three different shapes

creos™ xenotape
creos™ xenoplug
creos™ xenocote

Features‒ Soft, white, pliable, non-friable, absorbent
sponges made from collagen obtained frombovine deep flexor (Achilles) tendons.
‒ Indicated for application to moist or bleedingclean oral wounds created during dental
surgery, to control bleeding and protect thesurface of the wound from further injury.
‒ Can be used during surgical procedures
prior to wound closure or left in-situ.

BovineRegenerative product portfolio

Applications
Depending on the chosen wound dressings product,
one or more of the following applications are suitable*:‒ Minor oral wounds‒ Closure of grafted sites‒ Repair of Schneiderian membrane‒ Palatal donor sites‒ Mucosal flaps‒ Extraction sites‒ Biopsy sites*See Instructions For Use for full prescribing information, including indications,contraindications, warnings and precautions.

Arrive ready to use and are easy to handle.

Scan the code formore resources.

23Regenerative product portfolio

Cytoplast™ PTFE
Non-absorbable monofilament
PTFE sutures

Smooth monofilament rod

Advantages of the 300 series
stainless steel needles
Cytoplast™ PTFEPTFE Competitor

350x magnification

350x magnification‒ Gold standard material
for suture needles‒ Increased needle strengthand needle sharpness‒ Less force to penetrate

100% medical grade PTFE Biologically inert
Monofilament Does not wick bacteria

Resistance to bending
25

Soft (not stiff) Comfortable for patients
Little to no package memory Excellent handling, knots securely

49.5%
increase

Bending force

240

Non-resorbable Keeps the surgical site reliably closed

400 Series
steel needles*

300 Series
steel needles*common in dentistry

Needle shapes
TP 1/2 circle
Round-bodied

Thread diameters

Recommended knot1
Single throw reverse

2-0

3-0

4-0

5-0
Single throw forward
Double throw forward

RC 3/8 circle
Precision reverse
cutting

Regenerative product portfolio

25

Resorba® Glycolon™
Absorbable monofilament
PGA/PCL sutures

Advantages of the 300 series
stainless steel needles‒ Black needles‒ Manufactured frompremium tempered black‒ 300 series stainless steel

PGA – PCL copolymer Polyglycolic acid and polycaprolactone
Monofilament suture Provides excellent handling properties‒ Black steel provides more
contrast in the mouth foreasier visualization‒ Dark color doesn’t reflect light,
which is advantageous whensuturing under magnification

Monofilament Does not wick bacteria
Allows Atraumatic passage through the tissue
Maintains 50% of its tensile strength for 11–13 days

Needle shapes
HRT 1/2 circle
Round-bodied
cutting

Thread diameters

Recommended knot1
Single throw reverse

4-0

5-0

6-0
Single throw forward
Double throw forward

DSM 3/8 circle
Premium reverse
cutting

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Regenerative product portfolio

Pro-Fix™ precision
fixation system
Fast and easy placementof membranes, bone blocks
and tenting screws

Versatility and adaptability‒ Variety of bone fixation,
membrane fixation andtenting screws‒ Instruments designed to work
universally with all screw types

Ease of use‒ Autoclavable kit‒ Conveniently stores fixation
instruments and up to 100
fixation screws

Membrane fixation screws
to secure membranes and mesh
‒ Self-drilling design‒ Quick engagement in cortical bone
‒ No mallet or pilot holes needed

Tenting screws

to maintain space under
membranes in horizontal andvertical augmentation procedures‒ Self-drilling tip, polished neck,and broader head

‒ Designed for easy identification,
storage and simple reorderingof the screws.

Bone fixation screws

Stable and secure fixation‒ Self-tapping threads‒ Easy pick-up of screws, stabletransfer to the surgical site, quick
engagement into the cortical bone

‒ Threads with a cutting flute foreasier insertion into harder bone

to stabilize, fixate and support
bone grafts‒ Head design allows screw to be
screwed down flush to bone surface

Regenerative product portfolio

Master-Pin-Control
hybrid pin system
Precision fixation system

Replacement screws
Versatility and adaptability‒ Avoids micromobility of graft‒ Fixation of absorbable andnon-absorbable membranes

Ease of use‒ Extremely sharp tip‒ Allows for precise placement
into cortical bone

‒ Hybrid of screw and pin‒ The mini-threads on the pins
increase the surface areaof the shaft to allow forstability and easy removalLong screwdriver‒ Designed by Dr. Istvan Urban with
Meisinger to make pin removaleasier in hard-to-reach areas

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Regenerative product portfolio

Products
creos™ allo.gain
Bone particulate
min/demincortical

Vial

Medium0.25-1 mm

0.25 ccmineralized
corticocancellous
Mediummineralized
cancellous
Largemineralized corticalLargedemineralized
cortical

0.25-1 mm

0.5-1 mm

Large

Medium0.25-1 mm

0.5-1 mm

0.125-0.85 mm

Small

Medium0.25-1 mm

0.5-1 mm

0.125-0.85 mm

Small

0.5-1 mm

Large

N4510

N4511

N4210

N4211

N4110

N4111

N4112

N4310

N4311

0.50 cc

N4410

N4520

N4521

N4220

N4221

N4120

N4121

N4122

N4320

N4321

1.00 cc

N4420

N4530

N4531

N4230

N4231

N4130

N4131

N4132

N4330

N4331

2.00 cc

N4430

N4540

N4541

N4240

N4241

N4140

N4141

N4142

N4340

N4341

Bowl

min/demincorticalMedium0.25-1 mm

0.25 ccmineralized
corticocancellous
Mediummineralized
cancellous
Largemineralized corticalLargedemineralized
cortical

0.25-1 mm

0.5-1 mm

Large

Medium0.25-1 mm

0.5-1 mm

0.125-0.85 mm

Small

Medium0.25-1 mm

0.5-1 mm

0.125-0.85 mm

Small

0.5-1 mm

Large

N4510-B

N4511-B

N4210-B

N4211-B

N4110-B

N4111-B

N4112-B

N4310-B

N4311-B

0.50 cc

N4410-B

N4520-B

N4521-B

N4220-B

N4221-B

N4120-B

N4121-B

N4122-B

N4320-B

N4321-B

1.00 cc

N4420-B

N4530-B

N4531-B

N4230-B

N4231-B

N4130-B

N4131-B

N4132-B

N4330-B

N4331-B

2.00 cc

N4430-B

N4540-B

N4541-B

N4240-B

N4241-B

N4140-B

N4141-B

N4142-B

N4340-B

N4341-B

15 °C

25 °C

Made inUSA

creos™ allo.gain dbm putty
Size

Article no.

0.50 cc

N6110

1.00 cc

N6120

2.50 cc

N6130

15 °C

25 °C

Made inUSA

Symbol glossary
Temperature limit
Upper limit of temperature

Most commonly sold articles

Regenerative product portfolio

creos™ xenogain
Xenogenic bone graft substitute
Weight0.25 g0.5 g

1.00 g2.00 g15 °C

Granule size

VolumeVial

Bowl

Syringe

Small (0.2 – 1.0 mm)

0.36 cc

N1110

N1110-B

N1210

Large (1.0 – 2.0 mm)

0.54 cc

N1111

N1111-B

N1211

Small (0.2 – 1.0 mm)

0.82 cc

N1120

N1120-B

N1220

Large (1.0 – 2.0 mm)

1.27 cc

N1121

N1121-B

N1221

Small (0.2 – 1.0 mm)

1.71 cc

N1130

N1130-B

Large (1.0 – 2.0 mm)

2.69 cc

N1131

N1131-B

Small (0.2 – 1.0 mm)

3.64 cc

N1140

N1140-B

Large (1.0 – 2.0 mm)

5.74 cc

N1141

N1141-B

25 °C

Made inKorea

creos™ xenogain collagencreos™ xenogain + 10% porcine collagen type I
WeightBlock size

Article no.

0.1 g

6 x 6 x 6 mm

N1320

WeightSyringe size

Article no.

0.25 g7 x 8 x 9 mm

N1330

0.25 g

4.6 x 40 mm

N1410

0.5 g

9 x 10 x 11 mm

N1340

0.5 g

5.6 x 45 mm

N1420

2 °C

30 °C

Made in
Korea

Most commonly sold articles

29

30

Regenerative product portfolio

creos™ xenoprotect
Nobel Biocare’s highest selling
resorbable collagen membrane
Size

Article no.

15 x 20 mm

N1520

25 x 30 mm

N2530

30 x 40 mm

N3040

25 °C

Made inGermany

Cytoplast™ RTM collagencreos™ allo.protect

Resorbable, firm, collagen membrane

pericardium membrane

Size

Units/box

Article no.

Size

15 x 20 mm

2

CLMRTM1520

10 x 10 mm

N7110

20 x 30 mm

2

CLMRTM2030

15 x 20 mm

N7120

30 x 40 mm

2

CLMRTM3040

20 x 30 mm

N7140

15 °C

30 °C

Article no.

Made in
USA

15 °C

25 °C

Processed in
USA

Cytoplast™ TXT-200 PTFE membrane
Non-resorbable, high-density PTFE membrane
Shape

Picture

Size

Small

12 x 24 mm

Medium12 x 30 mm

Large

25 x 30 mm

15 °C

30 °C

Made inUSA

Most commonly sold articles

Thickness

Article no.

Units/box

200 μmTXT1224-1

1200 μmTXT122410

200 μmTXT1230

10200 μmTXT2530-1

1200 μmTXT2530

4

Description

Designed specificallyfor extraction
site grafting andaugmentation
procedures where
exposure to the oralcavity is common

Regenerative product portfolio

Cytoplast™ Ti-reinforced PTFE membrane
Non-resorbable, titanium reinforced, high-density PTFE membrane
Shape

PictureANL

Size
12 x 24 mm

ANL0

12 x 30 mm

AS

14 x 24 mm

BL

17 x 25 mm

BLL

17 x 30 mm

PS

20 x 25 mm

PST

36 x 25 mm

PL

25 x 30 mm

PLT

30 x 41 mm

XLK

30 x 40 mm

XL

30 x 40 mm

ATC

24 x 38 mm

PTC

38 x 38 mm

PD

38 x 38 mm

K2

40 x 50 mm

15 °C

30 °C

Made inUSA

Most commonly sold articles

Thickness

1 unit/box

2 units/box

150 μm

TI150ANL-N-1

TI150ANL-N-2

250 μm

TI250ANL-N-1

TI250ANL-N-2

150 μmn/a

n/a

250 μm

TI250ANL30-N-1

TI250ANL30-N-2

150 μm

TI150AS-N-1

TI150AS-N-2

250 μm

TI250AS-N-1

TI250AS-N-2

150 μm

TI150BL-N-1

TI150BL-N-2

250 μm

TI250BL-N-1

TI250BL-N-2

150 μm

TI150BLL-N-1

TI150BLL-N-2

250 μm

TI250BLL-N-1

TI250BLL-N-2

150 μm

TI150PS-N-1

TI150PS-N-2

250 μm

TI250PS-N-1

TI250PS-N-2

150 μm

TI150PST-N-1

TI150PST-N-2

250 μm

TI250PST-N-1

TI250PST-N-2

150 μm

TI150PL-N-1

TI150PL-N-2

250 μm

TI250PL-N-1

TI250PL-N-2

150 μm

TI150PLT-N-1

TI150PLT-N-2

250 μm

TI250PLT-N-1

TI250PLT-N-2

150 μm

TI150XLK-N-1

TI150XLK-N-2

250 μm

TI250XLK-N-1

TI250XLK-N-2

150 μm

TI150XL-N-1

TI150XL-N-2

250 μm

TI250XL-N-1

TI250XL-N-2

150 μm

TI150ATC-N-1

TI150ATC-N-2

250 μm

TI250ATC-N-1

TI250ATC-N-2

150 μm

TI150PTC-N-1

TI150PTC-N-2

250 μm

TI250PTC-N-1

TI250PTC-N-2

150 μm

TI150PD-N-1

TI150PD-N-2

250 μm

TI250PD-N-1

TI250PD-N-2

150 μm

TI150K2-N-1

TI150K2-N-2

250 μm

TI250K2-N-1

TI250K2-N-2

Description

Designed for narrow singletooth extraction sites, especiallywhere one bony wall is missing

Designed for single-tooth extraction
sites, especially where one ormore bony walls are missing

Designed for large buccal defects

Designed for large extraction sites
and limited ridge augmentation
Designed for large extraction sites
and limited ridge augmentationin the anterior maxilla
Designed for large bony defects,
including ridge augmentation
Designed for large bony defects,
including ridge augmentationin the anterior maxilla
Designed for very large bony defects,
including ridge augmentation

Designed for very large bony defects,
including ridge augmentation

Designed for large extraction sites,
including ridge augmentation

Designed for large bony defects,
including ridge augmentation
Designed for large bony defects,
including distal extensionof the posterior ridge
Designed for the largest bony defects,
including ridge augmentation

31

32

Regenerative product portfolio

Cytoplast™ MicroDerm
Allogenic acellular dermal matrix
Size

Thickness

Article no.

1 x 1 cm

1.2 +/-.02 mm

CMD1010NB

1 x 2 cm

1.2 +/-.02 mm

CMD1020NB

1 x 4 cm

1.2 +/-.02 mm

CMD1040NB

2 x 4 cm

1.2 +/-.02 mm

CMD2040NB

25 °C

Made in
USA

Cytoplast™ RTM wound dressings
Absorbable wound dressings
Size

Size

Units/box

Article no.

Plug

1 x 2 cm10

CLMRTMPLUG10

Foam

2 x 4 cm10

CLMRTMFOAM10

Tape

2.5 x 7.5 cm

10

CLMRTMTAPE10

10 °C

30 °C

Made inUSA

creos™ wound dressings
Product type

Configuration/size

creos xenoplug

0.375 in x 0.75 in(1 cm x 2 cm)

creos xenocote

0.75 in x 1.5 in(2 cm x 4 cm)

2 – 4 mm

WD62201

creos xenotape

1 in x 3 in

(2.5 cm x 7.5 cm)

0.3 – 0.8 mm

WD62200(10 per dispenser)

10 °C

30 °C

Made inUSA

Most commonly sold articles

Thickness

Article no.
WD62202

Regenerative product portfolio

Cytoplast™ PTFE
Non-absorbable PTFE suture – monofilament
Needle shape
TP 1/2 circle
Round-bodied

USP

Needle
size

4-0
2-0

3-0

RC 3/8 circle
Precision
reverse cutting
4-0

5-0

15 °C

30 °C

Needlecolor

Suture length 18 in.
12 units/box

Suture length 28 in.
12 units/box

13 mm

CS0618PERIO

CS0628PERIO

19 mm

CS0418

CS042816 mm

CS0518

CS052819 mm

CS051819

CS052819

16 mm

Black

CS0518BK

CS0528BK

19 mm

Black

CS051819BK

CS052819BK

13 mm

CS0618PREM

CS0628PREM

16 mm

CS0618RC

CS0628RC

13 mm

CS071813

CS072813

16 mm

CS071816

CS072816

TP 1/2 circle
Round-bodied

RC 3/8 circle
Precision reverse cutting

2-0

3-0

4-0

5-0

Made inUSA

Resorba® Glycolon™
Absorbable PGA/PCL sutures – monofilament
Needle shape

HRT 1/2 circle
Round-bodied
cutting

Needlesize

Needlecolor

Threadcolor

Suture length 18 in.
12 units/box

4-0

18 mm

SilverViolet

RMGOD01101

5-0

16 mm

SilverViolet

RMGOD01100

6-0

10 mm

SilverViolet

RMGOD01102

16 mm

SilverViolet

RMGOD01201

DSM 3/8 circle

18 mm

SilverViolet

RMGOD01203

Premium reverse cutting

13 mm

Black

Violet

RMGOD01210

16 mm

Black

Violet

RMGOD01211

16 mm

SilverViolet

RMGOD01214

18 mm

Black

Violet

RMGOD01212

18 mm

SilverUndyedRMGOD01202

13 mm

SilverUndyedRMGOD01200

13 mm

SilverViolet

RMGOD01213

4-0

DSM 3/8 circle
Premium
reverse cutting

5-0

6-0

15 °C

30 °C

HRT 1/2 circle
Round-bodied
cutting

USP

Made inUSA

Most commonly sold articles

4-0

5-0

6-0

33

34

Regenerative product portfolio

Pro-Fix™ precision fixation system
Instruments and screws for fast and easy placementof membranes, bone blocks and tenting screws

Membrane fixation kit Article PFMK20

Bone fixation kit Article PFBK12S

Products included

Products included

Size

Stabilization kit
Self-drilling membrane
fixation screw

1.5 x 3 mm

Qty.

Stabilization kit

120

Latch type pilot drill, 1.2 mm

1Tenting kit Article PFTK12Size

Stabilization kit

Self-drilling tenting screw

1.5 x 8 mm

2

1.5 x 10 mm

4

1.5 x 12 mm

4

1.5 x 14 mm

2

Individual components
Qty.
1

1.5 x 3 mm

4

1.5 x 4 mm

41.5 x 5 mm

4Stabilization kit includes‒ Storage tray with screw organizer dial
‒ Stainless steel driver handle‒ 76 mm cruciform driver blade‒ 56 mm cruciform driver blade

Made inUSA

Most commonly sold articles

Qty.

1

Self-tapping bone
fixation screw

Products included

Size

Description
Cruciform driver blade, 76 mm

1 unit/box
PFDB

Cruciform driver blade, 56 mm

PFDB56

Contra angle blade, 24 mm

PFDBCA

Stainless steel driver handle

PFDH

Autoclavable storage tray

PFT

Latch type pilot drill, 1.2 mm

HGMBI1001

Regenerative product portfolio

Membrane fixationscrewsBone fixation screws

Size

Size

5 units/box

1 unit/box

5 units/box

1.5 x 3 mm

PFMF-5

1.5 x 8 mm

PFB8

PFB8-5

1.5 x 5 mm

PFMF5-5

1.5 x 10 mm

PFB10

PFB10-5

1.5 x 12 mm

PFB12

PFB12-5

1.5 x 14 mm

PFB14

PFB14-5

Tenting screws
SizeSpecial

1.5 x 3 mm polished neck
1.5 x 4 mm polished neck

+4 mm threaded
portion

1.5 x 5 mm polished neck1 unit/box

5 units/box

PFT3

PFT3-5

PFT4

PFT4-5PFT5

PFT5-5

1.5 x 8 mm

Fully threaded

PFT8

n/a

1.5 x 10 mm

Fully threaded

PFT10

n/a

Master-Pin-Control hybrid pin system
Precision fixation system
Individual components
Description
Master-Pin-Control kit

Size

Article no.

34 pins

HGMBMP00

10 pins

HGMBMPBA

Description

Master-Pin-Control
replacement pins

Master-Pin longer screwdriver
Master-Pin-Control
decortication bur

Size

Article no.

10/pkg

HGMMP1050/pkg

HGMMP50

100/pkg

HGMMP100
HGMMP15
HGM203S-0120-RA

Made inGermany

Most commonly sold articles
Connect toNobel Biocare
Online store

35

36

Regenerative product portfolio

References
creos™ xenogain

creos™ xenoprotect

1. Nobel Biocare, data on file.

1. Aleksic Z. A multicenter clinical investigation demonstrates bone regeneration in severe
horizontal defects in the posterior mandibleusing creos xenoprotect: Interim results.
Conference: Europerio 9, July 2018. Read

2. Rhee S-H, Park HN, Seol Y-J et al. Effect of heattreatment temperature on the osteoconductivity of the apatite derived from bovine bone. 2006
Key Engineering Materials 309-311:41-44 Read
3. Arrighi I, Wessing B, Rieben A, et al. Resorbablecollagen membranes expansion in vitro. J Dent
Res 2014;93 (Spec Iss B):631 Read on Pubmed

2. Wessing B, Emmerich M, Bozkurt A. Horizontal
ridge augmentation with a novel resorbablecollagen membrane: a retrospective analysis of 36
consecutive patients. Int J Periodontics Restorative
Dent 2016;36(2):179–187. Read on Pubmed

4. Park JB, et al. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone
graft material (OCS-B). Clinical and histologic
findings in humans. The Journal of the Korean Dental
Association. 2007;45(8):491-99 Read on Pubmed

3. Bozkurt A, Apel C, Sellhaus B, et al. Differences indegradation behavior of two non-cross-linked collagenbarrier membranes: an in vitro and in vivo study. Clin
Oral Impl Res; 2014; 25(12):1403-1411 Read on Pubmed

5. Shin S-Y, et al. Long-term results of new deproteinized bovine bone material in a maxillarysinus graft procedure. J Periodontal ImplantSci. 2014;44;259-64. Read on Pubmed
6. Aleksic Z, Milikovic I, Lazic Z, et al. A multicenter
clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior
mandible using creos™ xenoprotect: Interim results.
J Clin Periodontol 2018;45(S19):306 Read
7. Park HN, Han, SH, Kim KW, et al. A study on
the safety and efficacy of bovine bone-derived
bone graft material (OCS-B). J Korean Acad
Periodontol. 2005 Jun;35(2):335 – 43 Read
8. Kim Y-T, et.al. Periodontal Repair on
Intrabony Defects treated with Anorganic
Bovine-derived Xenograft.J Korean Acad
Periodontol. 2007;37(3):489 – 96
9. Fernandez de Grado G, Keller L, Idoux-Gillet Y
et al. Bone substitutes: a review of their characteristics, clinical use, and perspectives for largebone defects management. Journal of Tissue
Engineering Volume 9: 1–18, 2018 Read on Pubmed
10. Zhang K, Fan Y, Dunne N et al. Effect of
microporosity on scaffolds for bone tissue
engineering. Regenerative Biomaterials,
2018, 115–124 Read on Pubmed

4. Gasser A, Wessing B, Eummelen L, et al. Mechanicalstability of collagen membranes: an in vitro study.
J Dent Res 2016;95(Spec Iss A): 1683 Read
5. Wessing B, Urban I, Montero E, et al. A
multicenter randomized controlled clinical trial
using a new resorbable non-cross- linked collagenmembrane for guided bone regeneration at
dehisced single implant sites: interim results ofa bone augmentation procedure. Clin Oral Impl
Res; 2017;28(11):e218–e226. Read on Pubmed
6. Sanz-Sanchez I, Wessing B, Polizzi G, etal. Randomized clinical trial comparing two
resorbable collagen membranes demonstrates good bone formation and soft tissue
healing with GBR at single implant sites
with dehiscence defects. J Clin Periodontol
2018;45(S19):19–20 [oral presentation]. Read
7. Omar O, Dahlin A, Gasser A, et al. Tissue
dynamics and regenerative outcome in two
resorbable noncross- linked collagen membranes
for guided bone regeneration: A preclinicalmolecular and histological study in vivo. Clin Oral
Impl Res; 2018;29(1):7–19 Read on Pubmed
8. Aleksic Z, Milikovic I, Lazic Z, et al. A multicenter
clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior
mandible using creos™ xenoprotect: Interim results.
J Clin Periodontol 2018;45(S19):306 Read
9. Raz P, Brosh T, Ronen G, Tal H. Tensile Propertiesof Three Selected Collagen Membranes.
Biomed Res Int. 2019 Dec 5;2019:5163603.
doi: 10.1155/2019/5163603. PMID: 31886222;
PMCID: PMC6915138. Read on Pubmed

Regenerative product portfolio

10. Jäger M, Degistirici O, Knipper A, Fischer J,
Sager M, Krauspe R. Bone healing and migrationof cord blood-derived stem cells into a critical size
femoral defect after xenotransplantation. J Bone
Miner Res. 2007;22(8): 1224-33. Read on Pubmed
11. Redemagni M, Mascetti T, Garlini G. PostExtractive Immediate Implant Placement
and Immediate Provisionalization at Sites
Requiring Buccal Bone Regeneration:. EC
Dental Science. 2019(18.6): 1207-16. Read
12. Cadenas-Vacas G, Martínez-Rodríguez N, BaronaDorado C, Sánchez-Labrador L, Cortés-Bretón
Brinkmann J, Meniz-García C, et al. Calcium Phosphate
Modified with Silicon vs. Bovine Hydroxyapatite for
Alveolar Ridge Preservation: Densitometric Evaluation,
Morphological Changes and Histomorphometric Study.
Materials (Basel) [Internet]. 2021;14(4): 940. Read
13. Bruyckere T de, Cosyn J, Younes F, Hellyn J, Bekx
J, Cleymaet R, et al. A randomized controlled study
comparing guided bone regeneration with connective
tissue graft to reestablish buccal convexity: One-year
aesthetic and patient-reported outcomes. Clin Oral
Implants Res. 2020;31(6): 507-16. Read on Pubmed
14. J. Jiménez Garcia, S. Berghezan, J.M.M.
Caramês, M.M. Dard, D.N.S. Marques, Effectof cross-linked vs non-cross-linked collagenmembranes on bone: A systematic review, J
Periodont Res. 2017;1–10. Read on Pubmed
Related studies/articles
Bruyckere T de, Eeckhout C, Eghbali A, Younes F,
Vandekerckhove P, Cleymaet R, et al. A randomized
controlled study comparing guided bone regeneration with connective tissue graft to re-establish
convexity at the buccal aspect of single implants:
A one-year CBCT analysis. J Clin Periodontol.
2018;45(11): 1375-87. Read on Pubmed
González Regueiro I, Martínez Rodriguez N, Barona
Dorado C, Sanz-Sánchez I, Montero E, Ata-Ali J,
et al. Surgical approach combining implantoplasty
and reconstructive therapy with locally delivered
antibiotic in the treatment of peri-implantitis: A
prospective clinical case series. Clin Implant Dent
Relat Res. 2021;23(6): 864-73. Read on PubmedDense PTFE membranes
1. Fotek PD, Neiva RF, Wang HL. Comparison of dermal
matrix and polytetrafluoroethylenemembrane forsocket bone augmentation: a clinicaland histologic
study. J Periodontol 2009;80:776-785. Read on Pubmed
2. Barboza EP, Francisco BS, Ferreira VF. Soft tissue
enhancement using non-expanded PTFE membranes
without primary closure [abstract]. Presented atthe 2008 Research Forum Poster Session. Annual
Meeting of the American Academy of Periodontology(AAP) in Seattle, WA, September 6-9, 2008.
3. Ronda M, Rebaudi A, Torelli L, Stacchi C. Expanded
vs. dense polytetrafluoroethylene membranes invertical ridge augmentation around dental implants:
a prospective randomized controlled clinical trial. Clin
Oral Impl Res; 2014 Jul;25(7):859-66. Read on Pubmed
4. Barboza EP, Stutz B, Ferreira VF, Carvalho W.
Guided bone regeneration using nonexpanded polytetrafluoroethylene membranes in preparation
for dental implant placements - a report of 420
cases. Implant Dent. 2010;19:2-7. Read on Pubmed
5. Hoffman O, Bartee BK, Beaumont C, Kasaj A, Deli
G, Zafiropoulos GG. Alveolar bone preservation in
extraction sockets using non-resorbable dense PTFE
membranes: A retrospective non-randomized study.
J Periodontol 2008;79:1355-1369. Read on Pubmed
6. Principles for Vertical Ridge Augmentation in the
Atrophic Posterior Mandible: A Technical Review. Urban
IA, Monje A, Lozada J, wang HL. Int J Periodontics
Restorative Dent. 2017 Sep/Oct;37(5):639-645.
7. Vertical Ridge Augmentation and Soft
Tissue Reconstruction of the Anterior Atrophic
Maxillae: A Case Series.Urban IA, MonjeA, wang HL. Int J Periodontics Restorative
Dent. 2015 Sep-Oct;35(5):613-23.
8. Partial lateralization of the nasopalatine nerve at
the incisive foramen for ridge augmentation in theanterior maxilla prior to placement of dental implants:
a retrospective case series evaluating self-reported
data and neurosensory testing. Urban I, Jovanovic
SA, Buser D, Bornstein MM. Int J Periodontics
Restorative Dent. 2015 Mar-Apr;35(2):169-77.
9. Vertical ridge augmentation with titanium-reinforced, dense-PTFE membranes and a combinationof particulated autogenous bone and anorganic
bovine bone-derived mineral: a prospective
case series in 19 patients. Urban IA, Lozada JL,
Jovanovic SA, Nagursky H, Nagy K. Int J Oral
Maxillofac Implants. 2014 Jan-Feb;29(1):185-93.

37

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Regenerative product portfolio

Other collagen membranes
Related studies/articles
Histomorphometric analysis of bone regeneration
using a dual layer of membranes (dPTFE placed
over collagen) in fresh extraction sites: a canine
model. Al-Hezaimi K, Iezzi G, Rudek I, Al-Daafas A,
Al-Hamdan K, Al-Rasheed A, Javed F, Piattelli A,
Wang Hl. J Oral Implantol. 2015 Apr;41(2):188-95.
Efficacy of using a dual layer of membrane(dPTFE placed over collagen) for ridge preservation in fresh extraction sites: a micro-computed
tomographic study in dogs. Al-Hezaimi K, Rudek
I, Al-Hamdan KS, Javed F, Nooh N, Wang HL.
Clin Oral Implants Res. 2013 Oct;24(10):1152-7.
Guided bone regeneration in long-bone defects
with a structural hydroxyapatite graft andcollagen membrane. Guda T, Walker JA, Singleton
Bm, Hernandez JW, Son JS, Kim SG, Oh DS,
Appleford MR, Ong JL, Wenke JC. Tissue Eng
Part A. 2013 Sep;19(17-18):1879-88. doi: 10.1089/
ten.TEA.2012.0057. Epub 2012 Sep 14.

Collagen wound dressing
1. Basma, H. S., Saleh, M. H. A., Abou-Arraj, R. V.,
Imbrogno, M., Ravida, A., Wang, H. L., Li, P., & Geurs,N. (2023). Patient-reported outcomes of palatal
donor site healing using four different wound dressing
modalities following free epithelialized mucosal grafts:
A four-arm randomized controlled clinical trial. Journalof periodontology, 94(1), 88–97. Read on Pubmed

Non-absorbable sutures
1. Abellán, D., Nart, J., Pascual, A., Cohen,
R. E., & Sanz-Moliner, J. D. (2016). Physicaland Mechanical Evaluation of Five Suture
Materials on Three Knot Configurations: An
in Vitro Study. Polymers, 8(4), 147. Read

Urban IA, Lozada JL, Wessing B, Suárez-López del Amo
F, Wang HL. Vertical Bone Grafting and Periosteal
Vertical Mattress Suture for the Fixation of Resorbable
Membranes and Stabilization of Particulate Grafts
in Horizontal Guided Bone Regeneration to Achieve
More Predictable Results: A Technical Report. Int
J Periodontics Restorative Dent. 2016;36(2):153159. doi:10.11607/prd.2627 Read on PubmedAbsorbable sutures
Related studies/articles
Physical and Mechanical Evaluation of Five
Suture Materials on Three Knot Configurations:
An in Vitro Study. Desire Abellán, José Nart,
Andrés Pascual, Robert E. Cohen, Javier D.
Sanz-Moliner. Polymers; 2016, 8(4), 147.
Vertical Bone Grafting and Periosteal Vertical
Mattress Suture for the Fixation of Resorbable
Membranes and Stabilization of Particulate
Grafts in Horizontal Guided Bone Regeneration
to Achieve More Predictable Results: A Technical
Report. Urban IA, Lozada JL, Wessing B, SuárezLópez Del Amo F, Wang HL. Int J Periodontics
Restorative Dent. 2016 Mar-Apr;36(2):153-9.
Suturing for optimal soft-tissue management.
Silverstein LH, Kurtzman GM, Shatz PC.
J Oral Implantol. 2009;35:82-90.
Suturing principles: Preserving needle edges during
dental suturing. Silverstein LH. PPAD 2005;17:562-564.
Vertical Ridge Augmentation and Soft Tissue
Reconstruction of the Anterior Atrophic
Maxillae: A Case Series. Urban IA, Monje
A, Wang HL. Int J Periodontics Restorative
Dent. 2015 Sep-Oct;35(5):613-23.

Fixation and tenting systems

Related studies/articles

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Taysi AE, Ercal P, Sismanoglu S. Comparison between
tensile characteristics of various suture materials
with two suture techniques: an in vitro study. Clin
Oral Investig. 2021 Apr 14. Read on Pubmed

Plonka, A. B., Urban, I. A., & Wang, H. L. (2018).
Decision Tree for Vertical Ridge Augmentation. The
International journal of periodontics & restorative
dentistry, 38(2), 269–275. Read on Pubmed

Silverstein LH, Kurtzman GM, Shatz PC. Suturing
for optimal soft-tissue management. J Oral
Implantol. 2009;35:82-90. Read on Pubmed

Urban, I. A., Monje, A., Lozada, J., & Wang, H. L. (2017).
Principles for Vertical Ridge Augmentation in the
Atrophic Posterior Mandible: A Technical Review. The
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Silverstein LH. Suturing principles: Preserving needle
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Regenerative product portfolio

Gultekin, B. A., Cansiz, E., & Borahan, M. O. (2017).
Clinical and 3-Dimensional Radiographic Evaluationof Autogenous Iliac Block Bone Grafting and Guided
Bone Regeneration in Patients With Atrophic Maxilla.
Journal of oral and maxillofacial surgery : official
journal of the American Association of Oral andMaxillofacial Surgeons, 75(4), 709–722. https://doi.
org/10.1016/j.joms.2016.11.019 Read on Pubmed
Wessing B, Urban I, Montero E, et al. A multicenter
randomized controlled clinical trial using a newresorbable non-cross- linked collagen membrane
for guided bone regeneration at dehisced single
implant sites: interim results of a bone augmentation procedure. Clin Oral Impl Res;
2017;28(11):e218–e226. Read on Pubmed
Principles for Vertical Ridge Augmentation in the
Atrophic Posterior Mandible: A Technical Review. Urban
IA, Monje A, Lozada J, Wang HL. Int J Periodontics
Restorative Dent. 2017 Sep/Oct;37(5):639-645.
Vertical Ridge Augmentation and Soft Tissue
Reconstruction of the Anterior Atrophic
Maxillae: A Case Series. Urban IA, Monje
A, Wang HL. Int J Periodontics Restorative
Dent. 2015 Sep-Oct;35(5):613-23.
Partial lateralization of the nasopalatine nerve at
the incisive foramen for ridge augmentation in theanterior maxilla prior to placement of dental implants:
a retrospective case series evaluating self-reported
data and neurosensory testing. Urban I, Jovanovic
SA, Buser D, Bornstein MM. Int J Periodontics
Restorative Dent. 2015 Mar-Apr;35(2):169-77.
Vertical ridge augmentation with titanium-reinforced, dense-PTFE membranes and a combinationof particulated autogenous bone and anorganic
bovine bone-derived mineral: a prospective
case series in 19 patients. Urban IA, Lozada JL,
Jovanovic SA, Nagursky H, Nagy K. Int J Oral
Maxillofac Implants. 2014 Jan-Feb;29(1):185-93.

39

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