References

Immuno-Biological Laboratories Co., Ltd.

#27745 Human ANGPTL2 Assay Kit - IBL

No.
1

Field
Heart disease
Heart disease

2Keywords
Cardiacdysfunction
Myocardialinfarction

Heart disease

Heart failure

Heart disease

Review (CAD)

Obesity

Dietary
modicication

ObesityInsulin resistanceObesity

Lifestyleintervention

ObesityInsulin resistance

CancerOsteosarcoma
metastasis

CancerPancreatic cancer

Cancer

Gastric cancer

Cancer

Gastric cancer

CancerCancerEsophageal
cancer/Prognosis_PredictionColorectal cancer

CancerColorectal cancer

2015

CancerColorectal cancer/
Recurrence

2014

CancerColorectal cancer/Resistant tochemotherapy
Breast cancer

2014

Risk Factor forCardiovascular
DiseaseRisk of type 2
diabetes
CKD

201634567891011121314

PublishedTitle
2017
Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction.
Tian Z et al. Circ J. 2017 Sep 8. doi: 10.1253/circj.CJ-17-0327.PMID: 28890470
2016
Acute effects of statin on reduction of angiopoietin-like 2 and glyceraldehyde-derived
advanced glycation end-products levels in patients with acute myocardial infarction: amessage from SAMIT (Statin for Acute Myocardial Infarction Trial). Shimomura M et
2015
Serum Angiopoietin-Like Protein 2 Concentrations Are Independently Associated with HeartFailure. Huang CL et al. PLoS One. 2015 Sep 23;10(9):e0138678.
PMID: 26397985
2009
Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome andcardiovascular disease. Oike Y et al. Circ J. 2009 Dec;73(12):2192-7. Epub 2009 Oct 29.PMID:
19875897
2019
Dietary modification reduces serum angiopoietin-like protein 2 levels and arterial stiffness inoverweight and obese men. Park J et al. J Exerc Nutrition Biochem. 2019 Sep 30;23(3):3944.PMID: 31743976
2018
Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistancein obese women. Kim J et al. Sci Rep. 2018 Sep 18;8(1):13976.PMID: 30228336
2011
Angiopoietin-like protein 2 sensitively responds to weight reduction induced by lifestyleintervention on overweight Japanese men. Muramoto A et al. Nutr Diabetes. 2011 Nov
7;1(11):e20.PMID: 23154406
2009
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesityrelated systemic insulin resistance. Tabata M et al. Cell Metab. 2009 Sep;10(3):178-88.
2020
Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lungpre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease.
Charan M et al. Oncotarget. 2020 Feb 4;11(5):510-522.PMID: 32082485
2018
Angiopoietin-like Protein 2 is a Useful Biomarker for Pancreatic Cancer that is Associatedwith Type 2 Diabetes Mellitus and Inflammation. Yoshinaga T et al. J Cancer. 2018 Nov25;9(24):4736-4741.PMID: 30588259
2015Angiopoietin-like protein 2 is a potential biomarker for gastric cancer. Yoshinaga T et al. Mol
Med Rep. 2015 Apr;11(4):2653-8.PMID: 25484242
2015
Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence
and prognosis in gastric cancer patients. Toiyama Y et al. Carcinogenesis. 2015
Dec;36(12):1474-83.PMID: 26420253
2015
Angiopoietin-Like Protein 2 Acts as a Novel Biomarker for Diagnosis and Prognosis in Patientswith Esophageal Cancer. Ide S et al. Ann Surg Oncol. 2015 Jan 7PMID: 25564164

2015

151617Cancer

2014

18
Epidemiological
19 research
Epidemiologicalresearch
Epidemiological
21 research2020132013

Angiopoietin-like protein 2 as a potential biomarker for colorectal cancer. Yoshinaga T et al.
Mol Clin Oncol. 2015 Sep;3(5):1080-1084.PMID: 26623054
Serum Angiopoietin-like Protein 2 Improves Preoperative Detection of Lymph Node
Metastasis in Colorectal Cancer. Toiyama Y et al. Anticancer Res. 2015 May;35(5):284956.PMID: 25964566
Elevated serum angiopoietin-like protein 2 correlates with the metastatic properties ofcolorectal cancer: a serum biomarker for early diagnosis and recurrence. Toiyama Y et al. Clin
Cancer Res. 2014 Dec 1;20(23):6175-86.PMID 25294915
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy byactivating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptoticsignaling. Horiguchi H et al. Cancer Sci. 2014 Dec;105(12):1550-9.PMID: 25287946
Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for thepathogenesis of breast cancer metastasis. Endo M et al. Int J Biol Markers. 2014 Sep
30;29(3):e239-45.PMID: 24585434
Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in theCommunity: The Hisayama Study. Hata J et al. Arterioscler Thromb Vasc Biol. 2016
Aug;36(8):1686-91.PMID: 27365403
Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: theHisayama study. Doi Y et al. Diabetes Care. 2013 Jan;36(1):98-100.PMID: 22966088
Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese
population: the Hisayama Study. Usui T et al. Clinical Trial Circ J. 2013;77(9):2311-7.PMID:
23739531
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References

Immuno-Biological Laboratories Co., Ltd.

#27745 Human ANGPTL2 Assay Kit - IBL

No.

Field
Atherosclerosis

22
Atherosclerosis

Keywords
Carotid IMT(intima-mediathickness)
CAD

23
Animal test

Interstitial
pneumonia

Animal test

Heart failure

Animal test

Insulin resistanceAnimal test

Tumor metastasis

Others

Dermatology(whitening )Others

Dermatomyositis

OthersGestational
Diabetes

OthersType 2 diabetes・
LAB (Lectin-like
oxidized LDLreceptor 1 ligand
containingapolipoprotein B)
Review

2425262728

293031OthersPublishedTitle
2015
Association of serum angiopoietin-like protein 2 with carotid intima-media thickness insubjects with type 2 diabetes. Jung CH et al. Cardiovasc Diabetol. 2015 Apr 15;14:35.
PMID: 25889082
2014"Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial
dysfunction and atherosclerosis progression. Horio E et al. Arterioscler Thromb Vasc Biol.
2014 Apr;34(4):790-800.PMID: 24526691"
2016
Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficientmice. Motokawa I et al. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L704L713.PMID: 27542805
2016
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac
function and energy metabolism. Tian Z et al. Nat Commun. 2016 Sep 28;7:13016.PMID:27677409
2015
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T
lymphocyte Accumulation and Leads to Insulin Resistance. Sasaki Y et al. PLoS One. 2015 Jul
1;10(7):e0131176.PMID: 26132105
2012
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. EndoM et al. Cancer Res. 2012 Apr 1;72(7):1784-94.PMID: 22345152
2019
UV-B-activated B16 melanoma cells or HaCaT keratinocytes accelerate signaling pathways
associated with melanogenesis via ANGPTL 2 induction, an activity antagonized by
Chrysanthemum extract. Satou G et al. Exp Dermatol. 2019 Feb;28(2):152-160.PMID:30554436
2012
The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis. Ogata A et al.
Biochem Biophys Res Commun. 2012 Feb 17;418(3):494-9.PMID: 22281496
2016
Association between Maternal Serum Concentrations of Angiopoietin-like Protein 2 in Early
Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus. Zhang Y et al. Chin Med J(Engl). 2016 Oct 5;129(19):2308-12.PMID: 27647189
2018
Association between angiopoietin-like protein 2 and lectin-like oxidized low-density
lipoprotein receptor 1 ligand containing apolipoprotein B in patients with type 2 diabetes.
Suzuki T et al. Clinical Trial J Int Med Res. 2018 Oct;46(10):4167-4180.PMID: 30157689

2017

32
33

OthersOthers34
Others
35

Review (HeartDisease)
Rheumatoid
arthritis (RA)2017

Lumbar spinal
canal stenosis

2014

2010

High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation.
Nathalie Thorin-Trescases et al. Oxid Med Cell Longev. 2017;2017:1096385. PMID:
PMC5613648
A New Causal Player in Accelerating Heart Disease Development in the Aging Oike Y et al.
Circ J. 2017 Sep 25;81(10):1379-1385.PMID: 28867689
Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammationin rheumatoid arthritis. Okada T et al. m J Pathol. 2010 May;176(5):2309-19.PMID: 20304962
Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration andhypertrophy of the ligamentum flavum in lumbar spinal canal stenosis Masuda T et al. PLoS
One. 2014 Jan 17;9(1):e85542.PMID: 24465594

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