CONFERENCE PROCEEDINGS: 6TH ANNUAL TB EXPERTS COMMUNITY MEETING“GETTING TO ZERO BY ADDRESSING LATENT TB IN ASIA”
Hanoi, 4‐5 August 2018

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Executive Summary
The TB Experts Community Meeting was held on 4‐5 August 2018 in Hanoi, Viet Nam. During thisconference strategies for ending TB were discussed with focus on addressing the seedbed of latenttuberculosis infection. There was consensus among all participants that community involvement must
increase in order for tuberculosis prevalence to decrease. Participants also agreed on the need forstronger emphasis on preventive care, especially among contacts of active tuberculosis patients, inhigh‐burden areas, and among other individuals at high risk of developing active tuberculosis. The
Stop TB Partnership Japan opened the conference followed by a warm welcome from the Viet Nam
Ministry of Health and the Viet Nam National TB Control Programme. Both reiterated Viet Nam’s
commitment to end tuberculosis and serve as pathfinding country for the Asian region and hightuberculosis burden countries around the world. Both the keynote speaker and Stop TB Partnershiprepresentative emphasized the need for comprehensive intervention to search, treat and prevent all– latent and active – forms of tuberculosis. The WHO representative stressed the importance ofprevention as part of the End TB Strategy and the foundation for country‐level implementation laidby the updated and consolidated guidelines. In a transition from policy to practice, representatives
from Viet Nam, South Korea, Pakistan, China, Taiwan and Indonesia shared country‐level aspirations
and experiences about intensified interventions to address latent tuberculosis infection in the various
countries. These presentations informed two subsequent lively panel discussions in high and low
tuberculosis burden settings.
On the next day, industry representatives shared ongoing developments and new research forrifapentine and interferon gamma release assays sparking engaged discussions on the role of industry
in facilitating greater uptake and broader implementation of comprehensive actions. Following thesepresentations, conference participants broke out into groups to discuss enablers and barriers to scale‐up for comprehensive interventions against active and latent tuberculosis in their respective country
settings. At the end of an intensive two days of discussions, all participants renewed their commitment
to return to their communities and actively promote comprehensive actions to end TB in Asia with astronger focus on integrated intervention against latent and active tuberculosis.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Background
Many of history’s greatest successes in the fight against preventable diseases have been characterizedby momentous shifts in people’s belief of what is possible. For too long, the world has believed that
ending TB is not possible, and that business as usual will suffice. We know that neither is true and that
we need a paradigm shift now more than ever. The End TB Strategy reflects this paradigm shift andmust be implemented with urgency and vigor.
In 2018 World Health Organization (WHO) initiated a momentous shift by publishing the updated‘Guidelines on the Management of Latent TB Infection (LTBI)’. The new WHO guidelines on LTBI
consider the probability of progression to active TB disease in a specific risk group, the epidemiology
and burden of TB, the availability of resources and the likelihood of a broad public health impact. Two
fragmented recommendations have been made for the management of LTBI, which resulted in a
number of guideline documents, posing a challenge to implementation. Therefore, several WHO
Member States requested consolidated guidelines on LTBI management. Along with the End TB
Strategy which has well‐defined milestones and targets to assess progress. Both represent a historic
opportunity to wipe out an epidemic that has been the cause of death, illness and suffering formillennia.
The Stop TB partnership Japan is proud to host the 6th Annual Asian TB Experts meeting, which washeld in Ha Noi, Vietnam from the 4th to 5th August 2018. This year’s meeting herald a new chapter inthe global response to TB by bringing together low and high burden country representatives from Asia
to discuss Getting to Zero by addressing LTBI in Asia. Regional and international experts will convene
to identify and address the challenges and best practices that should be adapted in order to achieve
the targets set by The WHO End TB Strategy.
In order for Asia to harness growing momentum behind the idea of bringing the global tuberculosis(TB) epidemic into the elimination phase, focus on key cities by will be paramount. The Zero TB
initiative was formed in 2014 with a particular focus on local government participation and catalytic
successes in multiple locations. To achieve this goal, the Project acts as a platform for association andmutual assistance between comprehensive programs ambitiously tackling TB in all its forms in specific,
geographically designed areas.
Overarching goal: Provide a forum for international discussion of action needed to achieve standards
for TB screening and prevention across Asia.
Objectives: Create a forum for the presentation and discussion of:
1. Identify best practices, challenges, and opportunities in the implementation and managementof LTBI in Asia.
2. Review the landscape of research including ongoing clinical trials of LTBI treatments and new
diagnostic tools.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018

DAY 1
Objective 1: Global overview of guideline updates
Prof. Toru Mori: Conference opening and objective setting
Professor Mori opened the conference with a brief welcome address during which he first thanked
the Viet Nam Ministry of Health and National TB Control Programme for agreeing to host the 6th
Annual TB Experts Community Meeting on Getting to Zero by Addressing Latent TB in Asia. Professor
Mori reflected on Japan’s efforts to reduce tuberculosis prevalence over the past several decades,
reducing prevalence from over 200/100,000 in 1965 to 30/100,000 in 2000 and down to less than
15/100,000 in 2015. Within these efforts, he emphasized the need to political commitment andcomprehensive action. He particularly stressed that comprehensive action must entail treating all
forms of TB, including latent TB infection. This is only feasible through multi‐sectoral and broad
stakeholder engagement. Closing with that statement, Prof. Mori welcomed all participants to theconference, reiterated the objectives of the meeting and once again thanked the participants for theirattendance and the authorities in their role as host.
Prof. Nguyen Thi Giang Huong: Welcome speech from Viet Nam Ministry of HealthOpening the two‐day conference with a warm welcome to Vietnam on 4 August 2018, Professor
Nguyen Thi Giang Huong, Director General for International Collaborations, Viet Nam Ministry of
Health, presented the current situation on tuberculosis in Viet Nam and globally. Prof. Huong
introduced Vietnam as one of the leading countries in controlling tuberculosis and having achieved
the three related Millennium Development Goals. She further elaborated on the central government’s
national strategy for tuberculosis control up to 2020 with a vision to 2030. Prof. Huong indicated that
Viet Nam has been proactive in working towards ending tuberculosis with support from the World
Health Organization (WHO) and from the Global Fund. Through this support, the National TB Control
Programme (NTP) of Viet Nam has continuously improved patient support, treatment, and prevention
of TB. Prof. Huong believed Vietnam has the potential to serve as a model for ending tuberculosis in
Asia and globally. In this role, Viet Nam NTP will promote comprehensive treatment for all forms oftuberculosis and encourages the treatment of LTBI in addition to treatment of active tuberculosis. In
conclusion, she stated that routine treatment of LTBI must be expanded worldwide to end TB.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

46th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Prof. Nguyen Viet Nhung: Welcome from Vietnam’s Tuberculosis Control Programme (NTP)
Introducing the Viet Nam NTP, Prof. Nguyen Viet Nhung, Director of the Viet Nam National Lung
Hospital, addressed current issues with tuberculosis treatment in the country. Prof. Nhung observedthat tuberculosis was diagnosed 136 years ago, yet, millions of people get new infections totuberculosis every year, and millions still die. There are billions of people in the world currently
infected with tuberculosis. He stated not enough attention has been paid to tuberculosis infection
treatment. During the a recent meeting between WHO Global TB Programme and Viet Nam NTP,
three main strategies were reiterated to eliminate tuberculosis: preventing infection, treating latenttuberculosis, and treating active tuberculosis. To end tuberculosis, Prof. suggested the need for fourtypes of innovation: innovation of thinking, technology, application, and investment. Prof. Nhung
argued everyone in the community must understand that tuberculosis is curable, and eradication of
the disease is feasible. He urged health professionals to also pay close attention to those with highrisk of infection as well as those with respiratory infections, asthma, and smokers. According to Prof.
Nhung, there should be routine annual check‐ups for tuberculosis, regardless of health. National andinternational awareness on this issue must expand.

5This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 20186
Prof. Richard Chaisson: Keynote address
Dr. Chaisson from Johns Hopkins University delivered the keynote speech on tuberculosis infection.
He compared defeating tuberculosis to killing the Greek mythological Nemean Lion. In his words, there
is no one way to defeat tuberculosis; multiple strategies must take place in order for effective
progress. Dr. Chaisson then reiterated the global target of reducing TB prevalence to one per million
people and deaths to one per ten million population. He emphasized the need to employ
comprehensive approaches to tuberculosis control: “Find TB, Treat TB, Prevent TB,” calling it aplatform for controlling tuberculosis globally. For finding tuberculosis, Prof. Chaisson suggested moreaction: going to people’s homes to collect sputum, rather than just waiting at health clinics for people
to come. Through active case finding of tuberculosis, treatment becomes more efficient andimmediate. According to Prof. Chaisson, preventing tuberculosis is equally important as treating active
TB. In homes with placebo treatment for tuberculosis infection rates lowered as patients were morecautious about spreading the disease with a 15% difference in households with preventive therapy.
Dr. Chaisson then presented new findings on one‐month rifapentine/isoniazid regimen for LTBI
treatment that proved non‐inferior to 9H standard treatment in people living with HIV. In summary
Prof. Chaisson concluded, to defeat TB, it is necessary to attack from several angles, just like the
Nemean Lion.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Dr. Suvanand Sahu: Paradigm Shift: What is required for Asia to achieve TB elimination?
Dr. Suvanand Sahu from the Stop TB Partnership emphasized the global danger of tuberculosis andcalled on the necessity of a “Paradigm Shift” as presented in the Partnership’s Global Plan. First, Dr.
Sahu addressed gaps between goals and actual progress on ending tuberculosis. Given the 90‐90‐90
targets stated in the Global Plan, he stated that 90% of all people with tuberculosis should be treated,
yet only 61% are actually placed on treatment. Similarly, of all MDR‐TB patients treated, 90% should
complete treatment successfully, yet only 12% of all MDR‐TB patients are successfully treated. Dr.
Sahu presented a target of “FIND. TREAT. ALL. #ENDTB.” By 2022, he urged treatment to increase by
30 million by 2022. Currently, Dr. Sahu lamented the poor coverage of tuberculosis treatment. In order
to eliminate tuberculosis, he stated, LTBI must be addressed alongside active tuberculosis.
Simultaneously, treatment must be carried out using the Zero TB Initiative, also known as the STP Plan:“Search, Treat, Prevent.” Preventive therapy and case findings must increase in order to achieve theeradication of tuberculosis. Although the goal is ambitious, Dr. Sahu believed this achievement isfeasible as modeled by the various examples from the US and Russia.
Dr. Mase Sundari: WHO updated LTBI Guidelines 2018
Dr. Mase from WHO presented the updated LTBI guidelines for 2018 and reviewed the risk ofdeveloping the disease along the cascade from infection to onset of active disease, but noted a higher
prevalence among those with risk factors such as diabetes, illicit drug usage, recent infection, and HIV.
Since such a small percentage of those infected are treated, Dr. Mase urged the all participants tomobilize their communities to engage more actively in LTBI management. By identifying reasons why
LTBI diagnosis and treatment fail, Dr. Mase believed these issues can be more acutely addressed. As
key barriers, she observed that tuberculin skin tests are inaccurate, not enough people are screened,
and active tuberculosis must be ruled out first as an additional step to treatment of latent TB. She also
noted that patients are less likely to take medication when they are asymptomatic and that only 41%
of newly enrolled patients complete medication. Among people living with HIV, Dr. Mase emphasizedthat chest x‐rays should be used to diagnose tuberculosis instead of sputum smears for more accuracy.
Dr. Mase also mentioned the benefits of the weekly 12‐dose regimen for adults and children two years
and above in countries with high tuberculosis incidence. For this regimen, treatment completion canbe defined as completing 11 out of 12 doses. According to Dr. Mase, research showed there is no riskof developing drug resistance unless the patient already had MDR‐TB to begin with. In conclusion, Dr.
Mase surmised that preventive treatment is feasible and scalable.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Prof. Le Van Hoi: Zero TB Viet Nam
Prof. Le Van Hoi, NTP’s Deputy Manager put forward Vietnam’s strategy towards ending the national
tuberculosis epidemic. He acknowledged the main issue in treatment of LTBI that the relevant
stakeholders do not sufficiently focus on prevention, but instead focus mainly on active TB treatment.
He expressed that this attitude must change and introduced the Zero TB Viet Nam project that
employs a new 5‐step framework: Raise detection through community integration and systematic screening Improve timely and effective treatment through more sensitive diagnostic algorithm and tools Improve of adherence via social support and promote latent TB infection treatment
 Raising notification from non‐NTP healthcare providers
 Prepare for scale up through evidence generation, dissemination and policy translation
The main goal of this project would provide cost effective model for sustainable nationwide adoption
to end tuberculosis. In order to achieve this goal, more active case finding activities via chest x‐ray
screening are needed. Prof. Hoi also emphasized the importance of screening elderly and high‐riskgroups. Equally important, intensified and integrated LTBI management is required to combat the
epidemic. With regard to testing for TB infection, Viet Nam mainly employed TSTs in the past, but Prof.
Hoi encouraged a more widespread usage of IGRA due to its accuracy gains. Prof. Hoi expressed Viet
Nam’s next steps that should include providing more testing and expecting to implement 3HP.

8This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Dr. Hee Jin Kim: TB Free Korea ProjectDr. Hee Jin Kim, director of the Korean Institute of Tuberculosis, presented the success of tuberculosis
treatment in South Korea through the TB Free Korea Project. Treatment completion rates were very
high at 83%‐88%, but could still be improved to reach the goal of 90%. Despite this, Dr. Kim stated that
Korea has succeeded with this project. Some aspects of the program included a registration system,
similar to the US system of requiring children to have TB screening before 1st grade. Dr. Kim highlighted
the importance of a legal framework; all health care workers, maternity units, teachers, andeducational units need screening and treatment. Dr. Kim quoted from a recent study that found only
2.1% in a sample of first graders testing positive for latent tuberculosis. As a final point, Dr. Kim
stressed to definitely treat LTBI in areas of high risk, consider treatment in moderate risk areas, andapproach with caution for areas in low risk.
Dr. Aamir Khan: Creating Islands of Elimination: Zero TB Karachi
Dr. Aamir Khan, Executive Director of Interactive Research and Development, presented the Zero TB
Karachi project, a seminal initiative that may offer a blueprint for eliminating tuberculosis in Southeast
Asia. Dr. Khan viewed Zero TB not just an intervention, but as a social movement involving thecommunity and all individuals. As a social movement, Dr. Khan presented participants in thecommunity getting involved to reduce social stigma reduction, ranging from prominent figures driving
the Ao TB Mitao slogan to 40,000 schoolgirls helping with screening for persons with suspected TB in
the community. The project reportedly is set to have activities in each of the four provincial capitals
by 2020. Dr. Khan stated this program tries to obtain private and public support, as well as support
from NGOs. Public health facilities have set up screening sites at all outpatient departments, with two
specific sites for latent TB. In private sectors, there have been active case finding activities, mobile X‐
rays camps, and expanded GeneXpert deployment. As part of their activities, the project has verbally
screened 2.9 million individuals and identified 7,500 tuberculosis cases. Dr. Khan once againemphasized that preventive therapy programs should not be a standalone intervention. Instead,active case findings should link with the preventive therapy programs.
Dr. Wang Lixia: TB Control in China
Dr. Wang Lixia, presenting on behalf of the China CDC, followed suit and outlined the success of the
tuberculosis control efforts in China. In particular, Dr. Wang noted that TB incidence in China declined
at more than twice the global rate since 2000. Dr. Wang observed China has reached the tuberculosis
target five years early and continues to progress towards ending TB, while maintaining high treatment
success rates of around 95%. Dr. Wang also indicated that research on tuberculosis in China, bothinternational and domestic, has increased in recent years and that diagnosis and treatment standards
have been updated to classify LTBI as a new standard patient category. Additional efforts to improve
the tuberculosis burden in the country include efforts to reduce the economic burden on TB patientsand ensure access to free annual physical examination for every single person. To actively combat
tuberculosis in China in the future, Dr. Wang identified the need for a (better) vaccine, a reduction in
the MDR‐TB epidemic, and increased emphasis on preventive treatment. Additionally, to improve theThis meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
system, Dr. Wang believed consolidation is necessary, alongside improved accessibility and quality,and essential supports for patients and service providers.
Prof. Anita Chan: TB in Taiwan
Professor Chan shared the current progress of tuberculosis control in Taiwan, illustrating the successof the country’s efforts. From 2005‐2017 tuberculosis incidence had declined from 17,000 to less than
10,000, particularly subsequent to the inclusion of TB services within Taiwan’s universal healthcoverage schemes. Today’s TB epidemic in Taiwan is concentrated among the elderly and Dr. Channoted that reaching the 2035 goal for those older than 45 will be difficult. While tuberculosis rates
among PLHIV in Taiwan are much higher, the absolute number of cases has continuously declined. A
key legislative change was the mandatory reporting of tuberculosis. The Taiwan CDC coupled thisnotification mandate with the UHC, where since 1997 TB cases not reported in the registry would not
trigger reimbursement. Subsequently, a web‐based system for tuberculosis reporting was instituted
nationwide. Prof. Chan explained the relationship between NTP and NHI, which planned toautomatically link cases to national TB Case Management System in 2018 via RFID card. In the end,
Prof. Chan noted five key elements to end TB:
1.
2.
3.
4.
5.

Good case holding and DOTS
Strong political commitment
Focus on contacts and children first
Expansion step by step
Evaluation and monitor

Dr. Erlina Burhan: TB elimination in Asia/ MDR TB
Dr. Erlina Burhan, Vice Chairman of TB Working Group from Indonesia, underlined the current flaws
in treating tuberculosis globally of continuing to do the same thing and expecting different results. Dr.
Burhan noticed the current optimal rate of TB incidence decline at an average of about 10% annuallywith new tools, new vaccines, new treatment regimens and TB prophylaxis as opposed to the current
global annual decline of 2%. At this rate, global tuberculosis elimination achievement will not occur
until 2270 she stated. Since 2007, WHO endorsed seven new diagnostic methods, with six still indevelopment. There are an estimated 110,000 MDR‐TB cases among notified pulmonary TB cases, but
only 35,000 are diagnosed and only 32,000 are started on treatment, Dr Burhan bemoaned, suggesting
continuing the same path will neither be productive nor successful. The main levers to rectify thisissue, according to Dr. Burhan, is to introduce new, feasible and accessible treatments and diagnostic
tests. Shorter regimen and additional new drugs besides bedaquiline, delamanid, and proteonamid
are needed. Two‐month treatments should be standard as six‐month treatments are much too
lengthy. Treatment of LTBI equally needs to be implemented and efficient vaccines are required. Most
importantly, Dr. Burhan urged social protection and funding would need to increase in order for the
execution of these strategies.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Panel discussion on country experiences on the management of LTBI. Identification of bestpractices, challenges, solutions, and opportunities.
Low‐burden country panel
Moderator: Richard Chaisson (USA)
Panelists: Justin Denholm (Australia), Chi Chiu Leung (Hong Kong), Cynthia Chee (Singapore), Seiya
Kato (Japan)
Question from moderator: What is your policy on contacts? How do you prioritize? How do you treat
child contacts? How do you evaluate them?
 Japan: We give treatment from six to nine months for contacts with LTBI. We recommend
using both the IGRA and TST.
 Hong Kong: We focus on contacts of smear positive index cases. For testing of latent TB
infection, we are using TST and IGRA, but patients have to pay extra for the latter. About 5%
opt to do so.
 Australia: A contact is anyone who has more than 8 hours of contact with tuberculosis daily,
especially those who have more concentrated recently or those who have had prolonged
contact. Children under the age of five have higher risk of progression to active disease, as
well as significantly older population groups. However, I believe we should have broader
inclusion criteria for testing.
 Singapore: Screening is a national policy for pulmonary health. Nursing care, prisons, andschools are high‐risk areas. For those contacts five and over, we treat with nine months of
INH.
 USA: Prof. Chaisson commented that in the US, 4R is used universally as no one uses INH
anymore. Access to rifapentine continues to be a problem, which will hopefully be changed
soon. He also commented that rifampin is convenient because patients may receive treatment
regardless of whether or not they are infected. The treatment length does not matter as much.

High‐burden country panel
Moderator: Masae Kawamura (USA)
Speakers: Erlina Burhan (Indonesia), Aamir Khan (Pakistan), Phalin Kamolwat (Thailand) , Nhung
Nguyen Viet (Viet Nam), Srikanth Tripathy (India), Camillo Roa (Philppines)
This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Question from moderator: What are some steps to take to reduce tuberculosis infection rates? Whatis the biggest challenge in your country for preventative treatment?
 Pakistan: The number of those infected or in close contact with the disease is too high. 1.8
million people are infected yearly. We should consider mass screening and treatment for LTBIin certain high risk populations such as contacts and slum dwellers. We need comprehensive
measures for testing and treating both active and latent TB.
 Indonesia: We need more people screened for LTBI. Diagnosis is the big challenge. We needto prove infection and rule out active tuberculosis since we are a high burden country. To test
the infection, tuberculin tests are not always available and IGRA is expensive. Even after
diagnosis, it takes time to enroll patients onto treatment.
 Philippines: The linkage with private practitioners must be strengthened. Of active
tuberculosis cases, 40% are still missing and many are suspected to be in the private sector.
Another problem is that parents do not want their children to go through treatment for theactive disease unless absolutely necessary and clear that it is TB. This makes it even harder toconvince them to treat LTBI.
 Thailand: We must educate the population and let them know why tuberculosis treatment isimportant. This applies mainly to active tuberculosis, so building awareness for treatment oflatent TB infection will be even more difficult. Another obstacle are the school contacts, which
spread quickly and are hard to reach and because of stigma within schools and communities.
 India: We must consider what happens in the primary health care facilities like the clinics. The
issue is the high number of people that would need treatment.
 Vietnam: We have 30 million persons with latent tuberculosis infection that would needtreatment, so the burden is large. A great challenge is using tuberculin for testing as supply is
short and the test is not very accurate.
 Comment from the moderator: Getting rid of the term “latent” in LTBI is essential so LTBI is
more urgent for treatment. The goal to eliminate tuberculosis is set at 2050, not 2270. The
biggest obstacle is ignorance about LTBI. They do not know that it is preventable, whytreatment is necessary, and the difference between latent and active tuberculosis.
 Comment from audience member Prof. Richard Chaisson: Clinical screening is enough fordiagnosis for child contacts. This eliminates the problem of needing tuberculin and IGRA.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018

Day 2
Dr. Brigitte Demers: Rifapentine and what the future holds
Dr. Demers from Sanofi introduced the history of rifapentine and the community’s shifting interest
from commercial product to academic area of interest. She then presented several studies that
culminated in regulatory approval such as the PREVENT‐TB/TBTC‐S26 study establishing non‐inferiority with 9H and the Soweto study the demonstrated non‐inferiority to 6H in PLHIV. Dr. Demers
reviewed the implementation of 3HP in countries with drug registration such as Taiwan and citedstudies that found superior completion rates compared to 9H at comparable tolerability. Dr. Demers
presented ongoing development efforts at Sanofi for new formulations such as an RPT/INH fixed‐dose
combination and dispersible 100mg (and 20mg) tablets for treatment of children. Other research
partnerships are aiming to address some of the outstanding gaps involving pregnant women, children<2 years, PLHIV on ART (particularly involving dolutegravir) and self‐administered treatment. Futurestudies also include periodic 3HP for PLHIV, expansion of the 1HP finding in PLHIV and use of RPT in
the treatment of active TB. Dr. Demers admitted Rifapentine is an old drug, yet argues it could still bean effective drug. Partnership and funding is necessary for effective implementation. She further
addressed concerns from the audience regarding pricing to state that GDF prices have been reduced
from $72 to $45 per patient, and that individuals of Asian descent might have higher prevalence ofside effects than those of Caucasian descent do.
Dr. Masae Kawamura: Ending TB: what will it take?
Dr. Kawamura opened her presentation with a reminder of the historical virulence of tuberculosis andthe passiveness with which current strategies approach tuberculosis diagnosis and treatment. In
agreement with prior speakers, she also emphasized the need for comprehensive action throughmodels such as the Zero TB, Search‐Treat‐Prevent approach and particularly stressed the need ofprioritized screening for better case finding and prevention as TB is not evenly distributed. Dr.
Kawamura stated as a concept, islands of elimination are powerful, especially in populated where
spread of patients differs and that prioritization rid the US of tuberculosis, not extensive innovation.
Dr. Kawamura reflected on the progress already made with the reduction in diagnosis turnaroundtime from 6 weeks to 2 hours advancing from culture to PCR. Dr. Kawamura further asserted that on
the diagnosis of TB infection we have made similar progress with the development of IGRA and theirrelative benefits over TST. To execute the plan of ending TB, Dr. Kawamura stated that focus should
heavily base on recent contacts and high‐risk individuals, such as those exposed to school outbreaks,
nursing outbreaks, prison outbreaks, and diabetics and HIV patients. With regard to LTBI treatment,
Dr. Kawamura reiterated that although people do not like to treat individuals who are not sick, LTBI
treatment is essential for reducing the epidemic and that it would not cause drug resistance. Since
LTBI treatment initiation is often challenging, an accurate test is essential. Dr. Kawamura opined thatit could be possible to cut waste and immediately treating high‐risk patients. However, she suggested
this strategy is not efficient nor moral: toxicity would be unnecessary and treatment could cause harm.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Discussion Group 1
Among the first discussion group members, the main question discussed involved the opportunities
that are applicable to low burden countries to increase case findings. In general, except for the US,
regular screenings, with employee chest x‐rays were standard. Focus increased on migrants, healthcare workers, and high‐risk areas such as prisons. The US currently does not offer annual chest X‐raysanymore. Contact investigations were also common, along with IGRA tests. The group indicated toprioritize active tuberculosis treatment with focus on active case finding and gave mixed responses on
diagnosing and treating LTBI.
Discussion Group 2During the second discussion, the focus centered on more proactive case findings within ones country.
All participants agreed that their countries needed more community involvement, with particularfocus on high‐risk individuals and high‐burden areas. Also agreed was that evaluation gaps needed todiminish. The group suggested inclusion of tuberculosis as part of national health insurance.
Disagreements occurred when discussing preventive therapy for risk groups. Some argued that theprophylaxis strategy would decrease tuberculosis transmission effectively, creating herd immunity.
However, others countered the claim by advocating for the right of the patients, not wanting toincrease unnecessary toxicity with additional medication.
Discussion Group 3
The third discussion group considered the past challenges and successes of active case finding. Acrosscountries, X‐rays are preferred, however, they are too expensive and there are not enough qualified
radiologists to read them. There are still setbacks involving social stigma around tuberculosis. Olderpatients have high mortality rates in Thailand because they come too late into the service. Often,
evaluation and treatment gaps occur with immigrants because some may be illegal. In the Philippines,
the same problem presents because of access barriers to public health care for select patient groups.
Lastly, this discussion group agreed that there is greater need for patient education and must
implement more active tuberculosis screening activities.
Discussion Group 4
Emphasizing on the social aspect of treating tuberculosis, the following group communicated concerns
about social awareness about the disease. The group mentioned social stigma, causing a gap in active
case finding. As such, the group agreed that greater efforts for removal of this obstacle are essential.
Across the board, the group further concluded that funding for active case finding needs to increase,
as well as training for healthcare providers as well as general awareness building and advocacy withinsociety.

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Discussion Group 5
The fifth discussion group considered the current evaluation gaps in active as well as latent casefinding. According to the group, the algorithm for household screening is present, but theimplementation is varied and problematic. The group suggested using four‐month rifampin regimen
for LTBI treatment in high burden areas. In addition, new employees should require office screenings,
hoping to close case finding gaps. The group also mentioned many patients were lost due to failure offollow‐ups.
Discussion Group 6
Along the vein of current issues in tuberculosis treatment, the final discussion group listed theirconcerns about barriers to reaching the 2030 goal. Human resources are a challenge. IGRA is still too
expensive for the people in Vietnam. TST are also available from the free market, but health insurance
does not cover the entire costs for the test. Active tuberculosis and LTBI are also treated unequally as
the health system and the patients do not prioritize preventive therapy. The government also does
not provide enough subsidies for TSTs or chest x‐rays. The group hopes that the integration ofcommunity health and social workers can be a way to cope with the increased burden of latent andactive tuberculosis cases once LTBI interventions are scaled up programmatically.

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This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018

Annex I: Conference agenda
Day 1
Saturday, 4th August
08:00‐08:30 Registration
08:30‐08:45 Welcome and objective setting
08:45‐09:00

Welcome to Vietnam from Ministry of Health

Toru Mori
Health Ministry Leaders

09:00‐ 09:15 Welcome from Viet Nam TB Control Program
Nhung Nguyen Viet
Objective 1: Global overview of guideline updates
Co‐Chair: Abdul Razak and Nguyen Viet Nhung
09:15‐09:45 Key note speech on TB Elimination
Dick Chaisson
Paradigm shift: What is required for Asia to achieve TB
Suvanand Sahu
09:45‐10:15
elimination?
10:15‐10:45 WHO Updated LTBI Guideline 2018
Mase Sundari
10:45‐11:00 Tea break
Objective 2: Elimination in action: Examples from countries in Asia
Co‐Chair: Justin Denholm and Luan Vo
11:00‐11:30 Zero TB Viet Nam
Le Van Hoi
11:30‐12:00 TB Free Korea ProjectHee Jin Kim
Creating Islands of Elimination: focusing on Zero TB Cities
Aamir Khan
12:00‐12:30(Durban, Pakistan)
12:30‐13:00 TB Elimination in China
Wang Lixia
13:00‐ 14:00 Lunch
Oven D’orExperience from Taiwan: Political commitment for LTBI diagnosis
Anita Chan
14:00‐14:30
and treatment among TB contacts
14:30‐15:00 Drugs Resistance TB: New tools and approach to End TB
Erlina Burhan
15:00‐15:15 Tea break
Objective 3: Panel discussion on country experiences on the management of LTBI. Identification of bestpractices, challenges, solutions, and opportunities
Panel discussion: Perspectives on LTBI ‐ Japan, Australia, HK, Singapore
15:15‐ 16:00
Moderator: Dick Chaisson
Panel discussion: Perspectives on LTBI – Indonesia, India, Thailand, Vietnam, Philippines,
Pakistan
16:00‐17:00
Moderator: Masae Kawamura
17:00‐ 17:15

Wrap up

Toru MoriThis meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

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6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Day 2
Sunday, 5th August
08:30‐08:45
Welcome and review of the day 1 program
Objective 4: Industry role in TB elimination
Co‐Chairs: Nick Paton and Hee Jim Kim
08:45‐ 9:15
Rifapentine and what the future holds
09:15‐09:45
End Game of TB Elimination: What will it take?
09:45‐ 10:00
Tea break
10:00‐ 11:00
Breakout groups and report back: How are we going to achieveelimination in Asia? Using the Zero TB pillars (Search, Treat, Prevent)identify key program gaps.
SONG DA – Group 1
SONG LO – Group 2
SONG THAO – Group 3
HEMISPHERES-Group 4
SONG HONG 1&2- Group 5
SONG HONG 1&2- Group 6
Structured discussions: reflections on initiating and scaling LTBI
11:00‐ 11:45
programs
11:45‐12:00

Closing speech and vote of thanks

Toru Mori

Brigitte Demers
Masae Kawamura
Nduku Ndunda

Toru Mori
17

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018

Annex II: List of ParticipantsJustin Denholm
Australia
Email: justin.denholm@mh.org.au

Richard Stapledon
Australia
Email: Richard.Stapledon@sa.gov.au

Peter Trevan
Australia
Email: peter.trevan@mh.org.au

Nduku Ndunda
Australia
Email: Nduku.ndunda@qiagen.com

Tin Maung Cho
Myanmar
Email: tmcho49@gmail.com

Brigitte Demers
CanadaEmail: brigitte.demers@sanofi.com

Vanthy Ly
Cambodia
Email: hou3@cdc.gov

Jiuwu Chen
China
Email: franklin.chen@qiagen.com

Wang Lixia
China
Email: wanglx@chinacdc.cn

Xin Shen
China
Email: shenxin@scdc.sh.cn

Cheng Jun
China
Email: chengjun@chinacdc.cn

Qichao Pan
China
Email: shenxin@scdc.sh.cn

Wang Qian
China
Email: wangqian@chinacdc.cn

Kaijin Xu
China
Email: zdyxyxukaijin@163.com

Hui Zhang
China
Email: zhanghui@chinacdc.cn

Wei ShaChina
Email: shfksw@126.com

Lin Zhou
China
Email: zhoulin@chinacdc.cn

Xiaojing Cui
China
Email: cuixiaojing86@163.com

Xiaobing Zhang
China
Email: zhangxiaobing@ipbcams.ac.cn

Adong Shen
China
Email: shenad16@hotmail.com

Lei Gao
China
Email: gaolei@ipbcams.ac.cn

Yanyan Niu
China
Email: niya.niu@qiagen.com

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

18

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Isabelle Cieren-Puiseux
FranceEmail: isabelle.cieren-puiseux@sanofi.com

Sofia ImadFranceEmail: sofia.imad@sanofi.com

Chi Chiu Leung
Hong Kong
Email: ccleungpnc@netvigator.com

Alan Chi-kuen Chan
Hong Kong
Email: chikuen_chan@dh.gov.hk

Suvanand Sahu
India
Email: sahus@stoptb.org

Nguyen Viet Nhung
Vietnam
Email: vietnhung@yahoo.com

Ameeta Joshi
India
Email: ameeta.joshi@gmail.com

Srikanth Tripathy
India
Email: srikanthtripathy@gmail.com

Prijanti SoepandiIndonesia
Email: priyantisoepandi@gmail.com

Diah Handayani
Indonesia
Email: diahzulfitri@yahoo.com

Telly Kamelia
Indonesia
Email: tellybahar@gmail.com

Erlina Burhan
Indonesia
Email: erlina_burhan@yahoo.com

Fathiyah IsbaniahIndonesia
Email: fey_emir@yahoo.co.id

Arya Wibitomo
Indonesia
Email: arya.wibitomo@sanofi.com

Ida Parwati
Indonesia
Email: idaparwati2008@gmail.com

Dyah Erti Mustikawati
Indonesia
Email: dyahmustikawati0@gmail.com

Rina Triasih
Indonesia
Email: rina_triasih@yahoo.com

Wiranata Khiat
Indonesia
Email: wiranata.khiat@ubcindonesia.com

Heda Melinda Nataprawira
Indonesia
Email: heda_1155@yahoo.com

Nathan Tirtana
Indonesia
Email: tirtana.n@gmail.com

Nastiti Kaswandani
Indonesia
Email: nkaswandani@ikafkui.net

Seiya KatoJapan
Email: kato@jata.or.jp

Toru MoriJapan

Jin Takasaki
Japan

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

19

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Email: tmori-rit@jata.or.jp

Email: jintakajj@gmail..com

Hidetoshi Igari
Japan
Email: hide306@gmail.com

Takashi Kitoh
Japan
Email: takashi.kitoh@qiagen.com

Sang Nae Cho
Korea
Email: raycho@yuhs.ac

Hee Jin Kim
Korea
Email: hatchingbird@yahoo.co.kr

Jae Seuk Park
Korea
Email: jspark@dankook.ac.kr

Unyeong Go
Korea
Email: unyngo@korea.kr

Kim Jusang
Korea
Email: kimjusang@catholic.ac.kr

Sunny Park
Korea
Email: sunny.park@qiagen.com

Sujong Lee
Korea
Email: sujong.lee@qiagen.com

Adeeba Kamarulzaman
Malaysian
Email: adeeba@ummc.edu.my

Abdul Muttalif Abdul Razak
Malaysian
Email: drrazak@gmail.com

Naiemy Binti Reffin
Malaysian
Email: drnaiemy@moh.gov.my

Zamzurina Abu Bakar
Malaysian
Email: zamzurina76@yahoo.com.my

Noorliza Mohamad Noordin
Malaysian
Email: noorliza.noordin9@gmail.com

Alvin Lee
Malaysian
Email: Alvin.lee@qiagen.com

Jack Yap
Malaysian
Email: Jack.Yap@qiagen.com

Asmah Binti Razali
Malaysian
Email: dr.asmahrazali@moh.gov.my

Aamir Khan
Pakistan
Email: aamir.khan@ird.global

Regina Berba
Philippines
Email: rpberba@gmail.com

Camilo Roa
Philippines
Email: Camiloroa@yahoo.com

Roderick Africa
Philippines
Email: eaafrica@unilab.com.phCynthia Chee Bin Eng
Singapore
Email: cynthia_chee@ttsh.com.sg

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

20

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Romy Ho
Singapore
Email: romy.ho@qiagen.com

Refiloe Matji
South Africa
Email: refiloem@urc-sa.com

Jann-Yuan Wang
TaiwanEmail: jywang@ntu.edu.tw

Yiwen Huang
TaiwanEmail: jywang@ntu.edu.tw

Pei-chun Chan (Anita)
TaiwanEmail: pcanita.tw@gmail.com

Anchalee Avihingsanon
Thailand
Email: anchaleea2009@gmail.com

Phalin Kamolwat
Thailand
Email: phalin1@hotmail.com

Tawee Chotpitayasunondh
Thailand
Email: cctawee@gmail.com

Charoen Chuchottaworn
Thailand
Email: charojnj@hotmail.com

Nicholas PatonUK
Email: nick_paton@nuhs.edu.sg

Kimberly Green
USA
Email: kgreen@path.org

Rachel Forse
USA
Email: rachel.forse@tbhelp.org

Andrew Codlin
USA
Email: andrew.codlin@tbhelp.org

Dang Ngo
USA
Email: dang.ngo@clintonhealthaccess.org

Loyce Masae Kawamura
USA
Email: Masae.kawamura@qiagen.com

Sundari Mase
USA
Email: mases@who.int

Amy Bloom
USA
Email:

Richard Chaisson
USA
Email: rchaiss@jhmi.edu

Le Van Hoi
Vietnam
Email: hoilv@yahoo.com

Vo Nguyen Quang Luan
Vietnam
Email: luan.vo@tbhelp.org

Khieu Thi Thuy Ngoc
Vietnam
Email: kttngoc@gmail.com

Nguyen Binh Hoa
Vietnam
Email: nguyenbinhhoatb@yahoo.com

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

21

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Khuat Oanh
Vietnam
Email: oanhkhuat@scdi.org.vn

Tran Lien
Vietnam
Email: ltran@path.org

Luu TuanVietnam
Email: tluu@clintonhealthaccess.org

Tran Ngoc Phap
Vietnam
Email: phapqnam@gmail.com

Nguyen Anh
Vietnam
Email: nguyentuananh.fsh@gmail.com

Truong Thanh Huyen
Vietnam
Email: thanhhuyenntp@gmail.com

Giang Do
Vietnam
Email: dochaugianghcmc@gmail.com

Nguyen Giang
Vietnam
Email: nhgiang@gmail.com

Nguyen Huu Lan
Vietnam
Email: nguyenhuulan1965@yahoo.com.vn

Truong Van Vinh
Vietnam
Email: drvinhpnt@gmail.com

Le Phuoc Hung
Vietnam
Email: bslephuochung@yahoo.com.vn

Dang Thi Minh Ha
Vietnam
Email: hadtm2015@gmail.com

Nguyen Duc Bang
Vietnam
Email: mmdbang@gmail.com

Le Truong Giang
Vietnam
Email: letruonggiang05@gmail.com

Vu Nguyen Thanh
Vietnam
Email: thanh.vu@tbhelp.org

Mo Thi Lan Huong
Vietnam
Email: huong.mo@tbhelp.org

Vu Nhat Linh
Vietnam
Email: linh.vu@tbhelp.org

La Thi Huyen Nga
Vietnam
Email: nga.la@tbhelp.org

Dong Thi Thu Thuy
Vietnam
Email: thuy.dong@tbhelp.org

Nguyen Quynh May
Vietnam
Email: quynhmvnguyen@gmail.com

Pham Huy Minh
Vietnam
Email:

Dinh Ngoc Sy
Vietnam
Email: syminhquan@gmail.com

Vu Quang Hieu

Nguyen Thu Anh

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.

22

6th Annual TB Experts Community Meeting: Getting to Zero by Addressing Latent TB in Asia
Hanoi, 4‐5 August 2018
Vietnam
Email: vuh@who.int

Vietnam
Email: thuanh.nguyen@sydney.edu.au

Nguyen Thi Hoang Yen
Vietnam
Email: Yen.Nguyen@finddx.org

Nguyen Thien Huong
Vietnam
Email: huong.nguyen@kncvtbc.org

Le Thi Ngoc Anh
Vietnam
Email: ngocanhhsph@yahoo.com

Phan Ha
Vietnam
Email: ha.phan@ucsf.edu

Pham Minh Khue
Vietnam
Email:

Alyssa Finlay
Vietnam
Email: avf0@cdc.gov

Ho Van Anh
Vietnam
Email: hny8@cdc.gov

Raditia NurcahyaIndonesia
Email:

Nguyen Thai
Vietnam
Email: nguyenthai@tekmax.com.vn

Duong Thi Huong
Vietnam
Email:
23

This meeting was made possible by the provision of an unrestricted grant to Stop TB Japan by
Sanofi‐Aventis and Qiagen.