Brown Bag Seminar No. 076
ブラウンバッグセミナー

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712.

(wed.)

12:10
12:50~Online(Zoom)

2022

12:15-12:40

Introduction
Seminar()12:40-12:50

Q&A

12:10-12:15

Presentation

https://temdec-med-kyushu-u-ac-jp.zoom.us/webinar/register/WN̲svVlbbhYTpiLBTXVptm7BA
Supported by Kyushu University,Q-AOS & TEMDEC

Circadian rhythm and chronotherapy
Chair: Assoc. Prof. Fumihiko YOKOTA (Research Promotion Coordinator of Q-AOS)

Professor

Shigehiro Ohdo

Graduate School of Pharmaceutical Science

The paired suprachiasmatic nuclei (SCN) is the circadianpacemaker in mammals. Clock genes ultimately regulates a vastarray of circadian rhythms involved in biological, physiological andbehavioral process. The clock genes are closely related to sleepand cancer. Clock gene regulates many diseases such as cancer,
immunological dysfunction, asthma, cardiovascular diseases,
metabolic syndrome and sleep disorders etc. Dosing time
Dr. Ohdo is a dean, Graduate School of Pharmaceuticalinﬂuences the eﬀectiveness and toxicity of many drugs. The

School of Medicine, Ehime University, Japan in 1988. In

pharmacodynamics of medications as well as pharmacokinetics

USA as a research associate. In 1990-1993, he worked as aninﬂuences chronopharmacological phenomena. Monitoring rhythm,Sciences, Kyushu University, Japan. He received Ph.D. in

1989-1990, he stayed in University of Southern California,assistant professor of Ehime University, School of Medicine.

overcoming rhythm disruption, and manipulating rhythm from theSchool of Pharmaceutical Sciences, Kyushu University. In

perspective of the clock genes play an important role to improve

he has worked as a professor. In 2010-2014, he worked as achronopharmacotherapy. Overall, clock genes are critical

he worked as a vice president of Kyushu University. In

candidates for therapy associated with immune system andIn 1993-2001, he worked as an assistant professor, Graduate
2001-2005, he worked as an associate professor. Since 2005,
vice dean. In 2014-2018, he worked as a dean. In 2018-2020,2020-2023, he will work as a dean, Graduate School ofautonomic nervous system, as shown by the accumulated data.

works as a Distinguished Professor.

Therefore, global collaboration among the academia, the hospital,

scientiﬁc articles including Nature Medicine, Nature

the government and the industry is essential to decrease the gap

Pharmaceutical Sciences, Kyushu University. Since 2021, heDuring his research carrier, he published more than 100
Communications, Nature Chemical Biology, Nature Synthesis

between drug discovery and development.

award of the Japanese Society of Clinical Pharmacology andKey Words

etc. He also received several scientiﬁc awards such as theTherapeutics, the award of the Pharmaceutical Society ofJapan and Minister of Education, Culture, Sports, Science and"Circadian rhythm""Clock gene""Chronotherapy"

Technology Award. His Current Research Fields are thedevelopment of new chronopharmacotherapy and new drug
discovery from viewpoints of molecular clock mechanism.

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