Guest

Terumasa Hino Jazz Trumpeter

Giving People Love and Bringing Them Joy. That’s Why We Are Here.

K A ZU O NAK A M U R A

Ta l k W i t h

T ER UM A SA H I N O

Giving People Love and Bringing Them Joy.
That’s Why We Are Here.
Kazuo Nakamura, Ph.D.

Founder & CEO
CMIC HOLDINGS, Co., Ltd.

Terumasa Hino
Jazz TrumpeterGiving People Love and Bringing Them Joy. That’s Why We Are Here.

Mr. Hino's paintings

KAZUO NAKAMURA

The long-term COVID-19 pandemic has shaken the very foundations ofinterpersonal interaction, forcing us to question what the essence ofcommunication is. In the U.S., if people fail, they are often given a second chance
to keep trying until they are able to get back on their feet. Japan, on the other
hand, is said to have a culture that does not tolerate failure and does not easily
let people obtain a second chance. How can Japanese society change to better
tolerate failure? Jazz trumpeter Terumasa Hino has embodied the concept of art
and wellness as a truly global individual ever since he moved his base of activity
to New York in 1975 during the peak of his popularity. CEO Nakamura invited
him as a guest to listen to his story.

wanted to play jazz, so when I waswould come to feel that I hate it.

younger, I went to a jazz café in

Anyway, I felt that I needed to go out

Shinjuku and stayed there for about 10

into the world with the trumpet.

hours practicing improvising with aNakamura As a matter of fact, you

single cup of coffee.

moved your base of activity to the

Nakamura I saw you grace the front

U.S., and you saw success in many

pages of Heibon Punch and othercountries around the world. How didmagazines right when jazz cafés were

you feel when you left Japan?

at their peak. We were all astonished

Hino I won the Shinjuku Jazz Awards inby how cool you looked. The free-jazz

1969, and I received a round-trip ticket

musician Toshinori Kondo* was in theto the U.S. as a prize. It was my first3

Talk WithTERUMASA HINO

Nakamura I often have the chance toorder-made tap shoes from a shoe

picture for the screen door of a nearbysame band as me in the light musictime to go to the U.S. I went throughplay golf with you, and I have asked

store in Ginza and made me practicetemple when she was 15, too.

club at university. I remember often

Honolulu and San Francisco before

you to serve as the director of thetap dancing. When I was about nine

Nakamura You are also extremely

seeing him copying your style as hefinally arriving in New York. This was at

Kobuchizawa Country Club. First,

years old and my lungs started totalented at drawing. I always ask you

played at night in the club room andthe height of hippie culture. Some

could I ask you why you started goingdevelop, he gave me an old trumpet

to join the judging committee for theon the cold campus during winter. He

people were walking through thedown this path?

and told me to practice with it. Every

Nakamura Keith Haring Collection

passed away last year, but he was theVillage half-naked while holding theirjazz club called the Five Spot Cafe,

Hino Are you talking about golf?

day, I went straight home from school

International Children’s Drawing

only person to go professional amongchildren. I could really sense the hippie

white trumpeters would come over toatmosphere. Sonny Rollins* wasus and start playing during the break

Nakamura You must be joking!

and practiced trumpet for two hours. I

Contest. You have held many solo

our band members. I produced an(laughs) I’m talking about the trumpet.

was tooting by myself while my friends

exhibitions as well, so I can see thatoriginal CD with him called “GOING

playing in the jazz club, and I went totime. They were asking Jackie McLean

Hino Oh, the horn. (laughs) It runs inplayed outside.

you come from an artistic family.

PLACES... FOR KEITH” dedicated tohear many other jazz musicians

to use them in his band. I was amazedmy family. My father was a tap dancer

When I was in junior high school, andHino Yes, I naturally thought that thisthe late Keith Haring. This CD is filled

performing too. My strongest memory

by the U.S. and the people in it.

my father was about to leave the big

was the path for me. When I was inwith Kondo’s passion and energy.

from my first trip to the U.S. was being

band he played in at the time to join ajunior high school, I attended theamazed and moved by thedifferent band, he told me,

Nihon Jazz School run by Hiroshi

performances.

“Terumasa, join the big band as the

Kamayatsu’s father, Tib Kamayatsu. My

From then on, I went to the U.S. every

third trumpeter in my place. There’s ajunior high school studies came

year. I did recordings with othergood teacher there, so learn fromsecond to that. (laughs)

people, too, and I felt that I wanted tohim.” This teacher was a man named

Nakamura How did you join the world

work in the U.S. I made up my mind

Nakamura Because you live in the U.S.,

Tsutomu Sato, the lead trumpeter ofof jazz?

and moved on June 10, 1975.

you can only spend less than half of

the Star Dusters. He played like Harry

Hino When I was a child and Satchmo

By the time I arrived, everyone alreadythe year in Japan, but I heard that you

James.* So, I went to the cabaret in(Louis Armstrong)* came to Japan, myknew that I was going to come, so I

didn’t know that and ended up having

Shinjuku every day to perform. On

father took me to the Asakusa

was invited to join Jackie McLean’s*

to pay taxes.

holidays, I would go to Tamagawa byInternational Theater to watch him live.

band, and I did so. This was just after

Hino Yes. I sold my apartment in

train and practice until dusk. That was

I was amazed and filled with emotion

Woody Shaw*6 went solo, so all the

Shirokane to pay the tax, and everwhat I was doing every day.

to see Satchmo in real life. We had atrumpeters in New York weresince, I have been making sure not toNakamura From morning till night?

lot of jazz records at home, and as I

Nakamura Did you ever start hating

wondering who would join Jackie

spend more than 183 days in Japan

Did you ever think of quitting thelistened to them, I naturally came tothe trumpet during your professional

McLean’s band next—it turned out toeach year. (laughs)*7

trumpet?

believe that I would become a jazz

career?

be me, a strange Japanese man.

Nakamura Many other topics caused a

Hino No. I guess I just enjoy artistic

artist.

Hino No. I felt that the world of jazz is(laughs) One thing that sticks in mybuzz, like that incident with cannabis.

things. I hear my grandma painted a

I needed to be able to improvise if I

my world whatever I may do, even if I

memory: when I was performing at a

Hino Yes, that happened. When weand a trumpeter, so he got me some12

*1 Harry James (1916–1983): An American jazz musician, trumpet player, and big band leader. He was chiefly active in the U.S. from the 1930s until the 1970s, and hebecame popular in the spheres of jazz and pop music for his elegant, sweet trumpet performances in the swing jazz style.
*2 Louis Armstrong (1901–1971): Nicknamed Satchmo. An American jazz trumpet performer, composer, and singer revered as the “king of jazz.”

4

5

Getting a Shock in
the U.S.

*3 Toshinori Kondo (1948–2020): A Japanese trumpeter and music producer.
*4 Sonny Rollins (1930–): An American jazz saxophone player.
*5 Jackie McLean (1931–2006): A Jazz saxophone player from New York, U.S.

Everyone Should Be Givena Second Chance to
Challenge*6 Woody Shaw (1944–1989): An American jazz trumpet player.

Giving People Love and Bringing Them Joy. That’s Why We Are Here.

KAZUONAKAMURA

KAZUO NAKAMURA

Talk WithTERUMASA HINO

punishment was only

people there.

warm sound with all my heart. But

Hino I recently composed and wrote

through diet and exercise.

suspended and that I had

Hino Yes, there was. The student’s

Japan doesn’t really return the favor. It

the lyrics for a song called “We Are All

Musicians might live recklessly while

actually been judged to befather apologized, saying that his son

makes me feel really lonely sometimes.

Bad Kids.” It has lots of lines like, “Ithey are young, but I think they growguilty. (laughs) I’ve been

was at fault. That student has grown

Nakamura There’s no vibration going

got scolded by that old man ’roundmore restrained with age. When I havethrough a lot, but fortunately

up to be a really good drummer.

on. The most important thing in

the corner” and “My dad beat me

the chance to work with you, I can see

my efforts have been

Nakamura As I see it, you did it

human relations is that if you receive aup.” The final lyric is “Let’s all bethat you really wake up early in therecognized and I even received

because you have an unparalleledgift, you need to give something back.

people who can say ’Thank you’morning to exercise and do othera medal. *8

sense of love for each student, andLife is full of both happy and sadand ’Sorry.’” Many people cannot say

activities. You always speak to

Nakamura You never know

you engage with each and every

moments, but everyone has forgotten

these words today.

everyone so kindly as well.

what will happen in life. But, if

student earnestly every day. I could

this fact. You can’t create art simply byNakamura Communication ability has

Hino I do my best to return thesomething bad happens tosense this love in you, and so I gained

criticizing others all the time. The same

truly fallen among Japanese people.

kindness that I have received fromsomeone, I’m not convinceda renewed sense of respect for yourgoes for business, too. Do you have

We need to reconsider the basics ofeveryone.

that makes themwarm, wonderful character. I think thisanything to tell the younger

communication.

Nakamura I have a concept I call art

were coming back from a concert tour

irredeemable. For example, the golfer

love that flows through you is part ofgeneration, or how you would like

Hino This goes for the people who

and wellness. You obviously havein Indonesia, the drummer had stuffed

Tiger Woods was at rock bottom at

the reason why you continue toJapan to be?

lead the country as well, but adults

artistic qualities in your life, but you

some cannabis into one of the drums. I

one point in his career, but he has

captivate your many fans. I had strong

Hino I don’t think it’s good to have aneed to be role models for children inalso have fulfillment and wellbeing.

asked for a couple of bags, and hecome back and everyone is now

misgivings about how the mass media

society where younger people are notterms of saying “Thank you” andYou have all the important things ingave me some. I don’t even smoke

singing his praises. However, Japan

reported it at the time, and as a result,scolded by anyone. When I was a“Sorry” when they should.

life, and I feel you have mastered theregular cigarettes, though. My father

does not have a culture like this.

I deeply felt that Japan needed tochild, I used to get told off by otherart of living. I am also moved by yourput the bags into an empty jar and left

Failures and setbacks are a part of life,change more.

people’s fathers from thedesire to share what you have withthem there.

but Japan does not give people a

Then one day, these narcotics officers

chance to get back up again after acame stomping in there all of asingle mistake. I feel that Japan cannot

sudden. They exclaimed, “You’re

become truly strong as a country

Terumasa Hino, right?” and I said

unless this culture changes.

“Yes,” and then the officers said that

Hino Yeah, Japan is the complete

they wanted to talk to me. My father
flushed the cannabis down the toilet

neighborhood. I often learned what I

Adults Who Cannot Say“Thank You” or “Sorry”

shouldn’t do because they scolded

Wanting to Return the
Kindness I Received

others as well.
I look forward to witnessing your future

me. If nobody says anything, then I

endeavors. Thank you for taking thethink we will see people doing

Nakamura You have stopped drinking,anything they want nonchalantly.

right? What brought you to make that

Hino There are many nasty people in

Nakamura Right now, our biggest

decision?

opposite. There is a culture of

the U.S., too, but at least they will say

problem in the organization is that we

Hino I woke up on my 45th

attacking others, and I think there is a“Hello” when you meet them. But incannot engage in arguments.

birthday and I realized that I

right away, so they didn’t find anything,

lot of jealousy, too. In Japan, people

Japan, many people just say nothing

Supervisors are reluctant to speak up

would not be able to keep

but they accused me of illegally

get punished and are made to feel

and walk away. Maybe they arebecause they do not want theirplaying the trumpet until 80

smuggling cannabis because theshame for causing scandals. However,reluctant to open up to others.

actions to be perceived as power

if I kept drinking at this rate.

drummer had told them that he gave itin the U.S., people are praised as aNakamura I am worried that people

harassment, and their subordinates

So, I quit drinking

to me. This was the same year that the“comeback kid” for getting back onhave lost their common sense in how

do not want to displease them. That’s

completely on my 45th

punishment for cannabis possession

their feet after overcoming failure.

to communicate when meeting,the sort of atmosphere we have.

birthday.

had become stricter, so the TV andNakamura You also had a scandal

especially given the trend to stayThings look smooth on the surface,

Nakamura You makenewspapers were all going wild.

about slapping in Setagaya. The

home during the COVID-19 pandemic.

but I can’t shake the feeling thatparticular efforts to maintainIn court, the prosecution requested an

media treated it as corporal

Hino They may lack love. Giving

everyone is suffering.

your physical strength

eight-month sentence with apunishment, which shocked me

people love, bringing them joy, andthree-year suspension. I thought that

initially. However, I later came to think

bringing smiles to their faces—that’s

meant that I was judged to bethat there was a relationship of trust

why we are here, right? With this in

PROFILE

innocent, but I later found out that thethat could only be understood by themind, I always aim to produce a really

Born in Tokyo on October 25, 1942. Started playing the trumpet at age 9. Ever since releasing his first album as a band leader in 1967, hehas been the center of attention in what was called the “Hinoteru boom.” As a fashionable musician, he engages in many different
activities, including performances in tours and festivals in Japan and abroad as well as appearing on magazine covers. In 1989, he became
the first Japanese artist to sign with the famous Jazz label Blue Note Records. He received the MEXT Minister’ s Art Encouragement Prizein 2001. In 2004, he received the Medal of Honor with Purple Ribbon, the ACA National Arts Festival Excellence Award in the recordings
category, and the Mainichi Film Award for Best Music. He has recently focused his efforts on charitable activities and teaching the next
generation. He also has distinguished achievements in the field of painting, with solo exhibitions and published collections. He is aninternational artist that represents Japan with unrivaled originality and artistic sense.

*7 The U.S.–Japan Income Tax Convention has a tax-exemption system for short-term residents. People are exempt from tax in the countries where they stay for a shorttime if they fulfill certain conditions, such as not staying more than a total of 183 days a year in the country of short-term residency.
*8 Terumasa Hino was awarded The Order of the Rising Sun, Gold Rays with Rosette in the spring of. 2019 (Editor's note)time to talk with me today.

TERUMASA
H I NO

Terumasa Hino

Series

CMIC Group’s Initiatives to Diversity & Inclusion

11

Megumi Hara

Make your life fulfillingby following your heartin your choices

Efforts to empower women are said to be the core ofdiversity promotion activities. What is the ideal way forcompanies to offer support so that women can fully
demonstrate their strengths and achieve success? COO
Oishi spoke with Megumi Hara, who became President ofOrphanPacific in October 2021.

Keiko Oishi
CMIC HOLDINGS Co., Ltd.
Representative Director, COO

Oishi You joined the company in
September 2015. Why did you choose
OrphanPacific?
Hara I worked as a hospital pharmacist
after I graduated from college, but I
realized that there were patients who
could not be saved with modern-day
drugs, so I moved to a pharmaceuticalcompany. In my previous job, I gained
experience in many roles including
projects for new products, academic
tasks and alliances. I often dealt withmedicines for chronic diseases withmany patients. There were alternative
drugs available, and so there weren't
many cases where people's lives

depended on one specific drug. I
gradually developed a desire to be
involved with drugs that can change
patients' lives and lifestyles, and thatwas how I gained an interest in orphan
drugs.*
Oishi What made you choose
OrphanPacific over the many otherpharmaceutical companies out there?
Hara I was interested in its businessmodel, which is unlike other companies.
Regular pharmaceutical companies
primarily bring drugs developed
in-house from the clinical development
phase to the sales phase. However,OrphanPacific uses a flexible approachto swiftly bring patients the medicine
they need. I felt that the small scale ofthe company allows it to do a wide
range of things.
Oishi In your seventh year at thecompany, you became president inyour 40s. What was it like when you firstheard about this promotion?
Hara You first told me about it on thephone. I was really surprised because I

didn't expect it at all. But I couldn't go
and ask you to give me time to think
about it, and I thought it would bebetter to give it a try rather thanrefusing and regretting it later, so I
accepted the offer. I couldn't sleep very
well for about a week afterward,
though. (laughs)
Oishi There's no such thing as having
zero worries or concerns when taking
on a new challenge.
Hara Orphan drugs have noalternatives, so they bear a heavy
responsibility in terms of supporting
patients' lives. I feel we have an
important mission at the company too.
To achieve a stable supply, it is crucial
to identify risks in advance and carefullyplan out strategies accordingly. Having
said that, when I heard about being
promoted to president, I was more
excited about the possibility for me tolead the company in an even better
direction going forward, compared toworries concerning risks.
Oishi There is a great social
responsibility, but that also makes ithugely fulfilling. What was the turning
point in your work?
Hara I guess it was when I became a
director in my second year at thecompany. I thought it would be too
early for me. The previous president
first gave me a tentative offer, andwhen I asked him the reasons for thepromotion, he told me "I want to bringscience into the board of directors," and"I want to achieve diversity. I am aforeign national in Japan, and you are awoman and part of the younger
generation." I accepted the offer as I feltthat I could continue to work toward
what I had aimed for until that time.
Oishi He knew the right words to win
you over. (laughs) Did your feelings
change or did you encounter any otherturning points before becoming
president?
Hara The previous president told me,

President, Representative Director, OrphanPacific
Ms. Hara worked as a clinical pharmacist in the university
hospital in Japan at the beginning of her career, andmoved to Otsuka Pharmaceuticals, Co., Ltd. She joinedOrphanPacific in 2015 out of a desire to be involved todeliver medicines that can change patients' lives, andpreviously worked as the Head of R&D and the Head of
Pharmaceuticals Affairs. She has been a board member
since 2016 and promoted to the President in October 2021.
She received her Master of Pharmaceutical Science degreefrom University of Kyoritsu College of Pharmacy and a MBAfrom Globis University.She is the third female president in
the CMIC Group.

OrphanPacificwww.orphanpacific.com/en"I want to train someone to follow afterme, and you are one of the candidates."That phrase lingered in my mind. I
wanted to be able to provide the best
choice for the company when the daycame to change over. As such, I studied
to gain essential knowledge and skills
for management and business.
Oishi You specialized in science, but
your perspective on your careerchanged by getting involved inmanaging the company.
Hara To tell you the truth, I had
absolutely no interest in management
at the start. (laughs) However, at manydifferent points in my journey I asked
myself what I wanted to do and what I
was looking for. When I needed to makea decision, I think I chose the path that
follows my own heart.
Oishi This is a good example of how
people with strength can change if

there is the impetus to do so.
Companies should build anenvironment that encourages more
employees to advance their careers,and provide opportunities that suit
their own individual areas of growth. In
closing, could you tell me your goals
going forward?
Hara This brings us back to the starting
point of our company, but I want tofocus on bringing orphan drugs to as
many patients as possible. There are still
many rare diseases with no establishedtreatment methods, but there are also
many orphan drugs in development. I
want to help the company grow as we
continue to think about what we can doabout this situation and the uniquethings we can bring to the table. I aim
to create a virtuous cycle where we canuse the income from our growth todevelop new drugs.

* Orphan drugs are pharmaceuticals designated by the Ministry of Health, Labour and Welfare that fulfill specific criteria, such as being targeted at less than 50,000 patients inJapan, and having a high medical need.

A new drug
discovery seed!

We make all kinds of measurements in nonclinical studies
Check drug properties and safetywith experimental animals and cells

Nonclinicalstudies

What kinds ofeffects? Why dothese effects
happen?

What happens
after you takeit?

How much isit safe totake?

Efficacy pharmacology study

Pharmacokinetic study

Safety study

Investigating many different propertiesof the drug using experimental animals,
cells and bacteria, and checking whether
it is suitable to move to humaninvestigations (clinical studies).

Are the effects displayed
properly in humans?
Is it safe?

How many times can
you take it daily?

Pharmacokinetic study

Biomarker measurement

Analyzing blood or other samples tocheck the drug's kinetics in thehuman body. This provides
information on how to take the drug.

Measuring different kinds of
biological information (biomarkers)
to evaluate what effects the drug
has in the body and how it affects
the patient's condition.

How should the drug
be stored?

Is the quality level
being maintained?

Does the product meetthe specifications?

Stability study

Quality test

Shipping test

Storing the drug under
specific conditions including
temperature, humidity, andlight, and checking for any

Checking the qualityof the drug using awide range ofanalytical

Checking whether the
product meets shipping
criteria.

changes in quality
over time.

equipment.

Clinicalstudies

Manufactureand sales
Approval

Check drug efficacy
and safety with humans

Deliver high-quality drugs
to patients

CMIC caters to new areas of demand related to nonclinical studies
How should development
progress going forward?

We offer support
for pharmaceuticalaffairs consulting andwe will prepare
application dossiers.

We offer support for R&D andwork related to approval
applications.

Consulting for early-stage
drug creation

Medical writing

What about nonclinical studies
with gene therapy drugs?

We are receiving
an increasing numberof orders regarding
gene therapy drugs.

Do you offer support for developing
regenerative medicine products?

We offer support for nonclinicalstudies with gene therapy drugs.

We hold quality tests for raw materials
through to the final product incompliance with GMP (GCTP) standards.

We can work with gene therapy
drugs—a field with growing demand

Quality tests for regenerative
medicine products

We evaluate safety with
GLP-compliant facilities forregenerative medicine
products.

[Abbreviations] GLP: Good Laboratory Practice, GMP: Good Manufacturing PracticeIn this edition,

we describe CMIC Group's nonclinical study services.
CMIC Pharma Science Co., Ltd. and CMIC Inc. provide nonclinical study services. Three laboratories in Japanand one laboratory overseas all work together to provide end-to-end support for many kinds of value chains.

Q

What’ s the difference between nonclinical and clinical studies?

Clinical studies are held at the final phase of drug

during clinical studies and after the drug has been

patients with the disease to confirm efficacy andclinical and nonclinical studies are essential indevelopment, whereby the drug is administered tosafety. Before these studies, tests are conducted

on cells, tissues and non-human animals to checkthe efficacy and safety of the drug. These tests
used to be called "preclinical studies" because

they are held before "clinical studies," but they are
now known as "nonclinical studies" because tests
are needed at many different phases, such as

Q

manufactured and brought to the market. Bothpharmaceutical development. CMIC Group

provides nonclinical study services that cater to awide variety of needs—from efficacy and safetyassessment for drugs in the preclinical phase toquality testing of drugs in the clinical phase, andeven shipping tests for factory-made post-market
drugs.

What are the advantages of CMIC's nonclinical studies?

Apart from our capabilities in conducting studies

development, as we can use the same analysis

regulations (including GMP and GLP), we also

nonclinical consulting and medical writing divisions

based on procedures defined by laws andmaintain full accreditation from the AAALAC

International (Association for Assessment andAccreditation of Laboratory Animal Care), allowing
us to carry out tests with due care for theprotection and welfare of experimental animals.
We also offer services that are ideal for global

method within our bases in Japan and the U.S. Our
are the largest of their kind in Japan. We leverage
our extensive experience in nonclinical study

commissions as we provide extensive support

ranging from drafting new drug development plans
to submitting applications.

CMIC Pharma Science's research bases
Hokkaido

Kobe Laboratory(Nishiwaki City)

Research Building I

CMIC Bioresearch Center(Kobuchisawa)Research Building II

Yamanashi

CMIC, Inc.
Illinois, USA

Hyogo

JAPAN
Sapporo Laboratory(Ishikari City)