Science First – Clinical study

Robust papilla regeneration andmarginal bone gain with Xeal™ andTiUltra™ surfaces: 2-year results
Clinical relevance

Excellent soft
tissue response

Robust regeneration of
the papilla, increased soft
tissue thickness and stable
keratinized mucosa height.

Improved soft
tissue health

Marginal bone gainfrom prosthetic
delivery to 2 years.

Both bleeding andgingival indices improved
from final prosthetic
delivery to 2 years.

Robust papilla regeneration and marginal bone gain: 2-year results from a prospective study.
Giacomo Fabbri, Giorgio Ban, Hyun-Chang Lim, Kwantae Noh. Presented at the The European
Association for Osseointegration (EAO) meeting September 2023 Berlin, Germany

The results− Robust papilla regeneration with 90% of sites
having full papilla height after 2 years.
− Increased keratinized mucosa height fromprosthetic delivery to 6 months, then stableto 2 years.
− Healthy gingiva surrounding the crown withno sign of inflammation at 98.1% of sites,
and 92.5% of sites showing no bleeding
after 2 years.
− Mean marginal bone level increased from
-1.12 mm at prosthetic delivery to -1.08 mm
at 1 year and -1.06 mm at 2 years.

Robust papilla regeneration: Jemt Papilla Index
improved throughout the study progression
Prostheticdelivery

6 months
post-PD

1 yearpost-PD

2 years
post-PD

0100%

180%

60%

240%

− No implant failure from 1 to 2-year follow-up.

20%

3
n=61

n=55

n=56

n=530%

Study design
A 3-year prospective
single-center clinicalstudy. Interim results.

Single-tooth
restoration inhealed premolar
and molar

61 patients

61 NobelActive
TiUltra implants
and On1 Base Xeal

61 screw-retainedrestorations(43 NobelProcera®)2 years fromprosthetic
deliverySample clinical case from the study

Implant insertion

Final prosthetic delivery

6 months

1 year

2 years

3 years

Images courtesy of Dr. Giacomo Fabbri, Italy

Clinical views and periapical radiographs at indicated time points. A 51-year-old male patient, non-smoker with a
missing first molar tooth in the maxilla (FDI position 16) received NobelActive TiUltra RP 5.0 x 8.5mm. Following
the digital impression, an On1 Base Xeal and an On1 Healing Cap were placed on top of the implant. The finalprosthesis was delivered 3 months later and consisted of an On1 Universal Abutment and a NobelProcera fullcontour zirconia crown. Note the marginal bone level stability and improvement of soft tissue health throughout
the follow-up.

Authors' conclusion“NobelActive implants with gradually anodized surface [TiUltra]
and restored with anodized abutment bases [Xeal] support
successful osseo- and mucointegration and continue topromote excellent bone and soft tissue response thereafter.”More to explore
Compendium: acomprehensiveapproach to design
the emergence profile

Xeal™ and TiUltra™:
The clinically provensurfaces

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