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Product Name : Peroxidase (PEO-301)

First issue : Oct. 9.2013
Revised: May. 31. 2022
SDS No. 939F

Safety Data Sheet
1 Chemical Product and Company Identification
Identification of the productProduct CodeSupplierName
AddressPeroxidase
PEO-301

Department
Phone
Fax

Recommended use and restrictions on use

TOYOBO CO.,LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan
Biotechnology Overseas Sales and Marketing Department+81-6-6348-3846+81-6-6348-3833
diagnostic product2 Hazard Identification
Important hazards

This product might be harmful if swallowed, because it
contains boric acid.

GHS classification
Physical hazards
Health hazards
Acute toxicity : Oral
Acute toxicity : Dermal
Acute toxicity : Inhalation (Gas,Vapour)
Acute toxicity : Inhalation (Dust,Mist)
Skin corrosion/irritation
Serious eye damage/Eye irritation
Sensitization : Respiratory
Sensitization : Skin
Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ toxicity(Single exposure)

Category 5
Not applicable
Category 2
Category 2ACategory 1B
Category 1(nervous system, gastrointestinal tract)
Category 3(respiratory tract irritation)
Category 1(kidneys)

Specific target organ toxicity(Repeated)
Aspiration
hazardEnvironmental hazards
Acute hazards to the aquatic environmentLong-term hazards to the aquatic environment Hazard to the ozone layer-:Classification not possible
GHS Label Elements
Symbol/Pictograms

Signal word
Hazard statements

DangerMay be harmful if swallowed.
Cause skin irritation.
Cause serious eye irritation.
May damage fertility or the unborn child.
Cause damage to nervous system, gastrointestinal tract.
May cause respiratory irritation

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Product Name : Peroxidase (PEO-301)

First issue : Oct. 9.2013
Revised: May. 31. 2022
SDS No. 939F

Safety Data Sheet
Cause damage to kidneys through prolonged or repeatedexposure.
Precautionary statements

Prevention Obtain special instructions before use.
Do not handle until all safety precautions have been readand understood.
Wear protective gloves/protective clothing/eye
protection/face protection.
Use only outdoors or in a well-ventilated area.
Do not breathe dust/fume.
Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
Response If inhaled: Remove person to fresh air and keep
comfortable for breathing.
Get medical advice/attentions if you feel unwell.
If in eye: Wash with plenty of water/soap. Take off
contaminated clothing and wash it before use.
IF ON SKIN: Wash with plenty of soap and water.
Take off contaminated clothing and wash before reuse.
If skin irritation occurs: Get medical advice/attention.
If in eye: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy todo. Continue rinsing. If eye irritation persists, getmedical advise/attention.
IF exposed or concerned: Get medical attention/advice.
Storage Store locked up.
Store in a well-ventilated place. Keep container tightlyclosed.
Disposal Dispose of contents/container in accordance withlocal/regional/national/international/regulation.

3

Composition/Information on Ingredients
Substance/Mixture
Chemical Nature
Chemical specificity
Concentration or concentration range
Cas #Ingredients Contributing to the Hazard
Common Chemical nameConcentration or concentration range
Chemical formula
Cas #4

MixturePeroxidase
Freeze and drying powder including enzyme
50 %(W/W)
9003-99-0Boric acid50% (W/W)
H3BO3
10043-35-3

First Aid Measures
Inhalation
Skin Contact
Eye ContactIngestion

Remove to fresh air. Consult a physician whenunpleasantness occurs.
Wash off with plenty of water. Consult a physician when
inflammation on the skin occurs.
Rinse cautiously with water for several minutes. Remove
contact lenses,if present and easy to do.Continue
rinsing.
Rinse mouth. Swill plentiful amount of water or milk for
immediate vomiting. Consult a physician.

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Product Name : Peroxidase (PEO-301)

First issue : Oct. 9.2013
Revised: May. 31. 2022
SDS No. 939F

Safety Data Sheet
Most important symptoms/effects, acute anddelayed.

Inhalation: cough, pant, pharygeal pain, nosebleed.
Skin: dryskin.
Eye: redness, pain
Ingestion: stomachache,derangement diarrhea headache nausea vomit

5 Fire Fighting Measures
Specific extinguishing methods
Precautions for fire-fighters

Water spray,dry chemical powder,or carbon dioxide etc.
Firefighter should work from the windward side.

6 Accidental Release Measures
Personal Precautions, protective equipment
and emergency procedure.
Environmental Precautions
Methods and materials for containment andcleaning up.

7 Handling and Storage
Handling
Technical Measures
Precautions

Wear protective gear to avoid eye/skin contact andinhalation. Do not work at leeward.
High concentrated waste fluid should not be directly
discharged into rivers.
Take up under vacuum using dust collecting filter, wash
residual spill with copious amounts of water. Use
cloth, paper or anything similar to soak up thesolution leaking out of the container.
(Waste water should be treatedwith activated sludge or adsorbed with activated carbon
Wear protective gear to avoid eye/skin contact andinhalation.
Do not drop the container to prevent the content poppingout.

StorageTechnical Measures
Incompatible substances and mixtures
Storage Conditions
Packaging Materials

Keep sealed container in freezer.
None specified.
Store under -20℃ to avoid deactivating.
Use the initial container of the product.

8 Exposure Controls/Personal Protection
Engineering controls
Occupational exposure limit,biological limit
Personal Protective Equipment
Respiratory Protection
Hand Protection
Eye Protection
Skin and Body Protection

Provide shower and eye washing apparatus nearby.
(Boric acid) TLV: TWA 2mg/m3, STEL 6mg/m3
Protecting mask
Protecting gloves
Safety goggles
Long sleeve working wear

9 Physical and Chemical Properties
Physical State, form and colorOdour
pHFlash Point
Explosiveness
Density
Solubility

Powder / Reddish-Brown
No odourca. pH 5.5 (1% W/V)
No information available.
No information available.
No information available.
Freely soluble in water.

10 Stability and Reactivity
Stability

Stable at temperatures below -20℃.When left for long at
Possible hazard reactions at room temperature,proteins might be degraded, which does
specific condition
not cause any hazardous reaction.

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Product Name : Peroxidase (PEO-301)

First issue : Oct. 9.2013
Revised: May. 31. 2022
SDS No. 939F

Safety Data Sheet
Conditions to avoid
Materials to avoid
Hazardous Decomposition Products

Prolonged storage under higher temperature than room
temperature and high humidity.
Oxidizing agent
No information available.

11 Toxicological Information
Boric acid
Acute Toxicity (Oral)
Skin corrosion/irritation
Serious eye damage/irritation
Sensitization
Germ cell mutagenicity

Rat LD50 2660mg/kg
Moderate irritation (guinea pig, 24hr, 72hr)
Rubefaction /Pain
No data available
Absence of data on multi-generation mutagenicity tests
and germ cell mutagenicity tests in vivo, and negative
data on somatic cell mutagenicity tests in vivo
(micronucleus tests)

Carcinogenicity
Toxic to reproduction

ACGIH (2005): Category A4Adverse effects on reproduction of parental animals anddevelopment of pups at doses producing no parental
toxicity.

Specific target organ toxicity(Single exposure)

Human:Gastrointestinal tract effects such as nausea,
vomiting, abdominal pain and diarrhea, and central nerve
effects such as lethargy, headaches, fever, increased
irritability and muscle convulsion.
Irritation of the upper respiratory tract.
Animal:cyanosis, tetany, spasm and shock-like symptoms at
dosing levels within the guidance value ranges for
Category 1.

Specific target organ toxicity(Repeated exposure)

Human:oliguresis, anuria, and nephropathy including renal
tubular necrosis.

12 Ecological Information
Acute hazards to the aquatic environment

Boric acid: Fish (Rainbow Trout)
LC50=78.1mg(Boron)/L(96hr)(Boric acid equivalent 447mg/L)

Persistence /Degradability

This product is biodegradable and does not remain on theenvironment for long.

13 Disposal Considerations
Residues
A pollution container and packing

Dispose of in accordance with all applicable local andnational laws and regulations.
Wash with copious amounts of water and waste conforming
to local regulations depending on the type of thematerial.

14 Transport Information
International regulations
IMO information
IATA information
Domestic regulations
Rail and road transportation information
Marine transportation information
Aviation transportation information

Not applicableNot applicableNot applicableNot applicableNot applicable5/5

Product Name : Peroxidase (PEO-301)

First issue : Oct. 9.2013
Revised: May. 31. 2022
SDS No. 939F

Safety Data Sheet
Specific precautions transport measures andconditions

Avoid direct sunshine and check the container and loading
to prevent leakage or turnover,fall and damage.Transport
in accordance with regulations.Do not load with foods andfeed. Keep at temperatures below -20℃.

15 Regulatory Information
Registration, Evaluation, Authorization and Restrictionof Chemicals (EU)Common Chemical nameConcentration or concentration range
Chemical formula
CAS#A following component of this product is included in
SVHC (Candidate list of authorization).
Boric acidca 50% (W/W)
H3BO310043-35-3

16 Other InformationNotice

The information shall not be taken as being all inclusive
and is to be used only a guide.All materials and mixtures
may be present unknown hazards and should be used withcaution.The SDS is subject to revision as new information
becomes available.The information in this SDS,to the bestof our knowledge, is accurate and correct. However,TOYOBO
makes no warranty and assumes no liability whatsoever inconnection with any use of this information.