Redensyl®
The hair growth galvanizer
TECHNICAL MARKETING PRESENTATION V14072014

Hair loss Market in Numbers

45 million

Men suffering fromhair loss in India

35 million

Men suffering fromhair loss in the USA

21 million

Women suffering fromhair loss in the USA

6,200$

Average cost of one hairtransplantation surgery
in 2012 1

47%

Hair loss sufferers would
spend their life savings
to regain a full head ofhair 1

1 Source : International Society of Hair Restoration Surgery, report of 2013

Inspired from Regenerative Medicine

How does your body repairs itself????

Thanks to stem cells
Human stem cells enable our body to self repair itself.

Stem cell research is the Holly Grail for Eternal Youth(stem cells enable the creation and reparation of neworgans).
More than 500 clinical trials have been initiated for humanbody repairing in 2013 (brain, pancreas, skin, muscles,…).
More information on: http://stemcells.nih.gov

Hair follicle stem cells give birth to new hairs on the scalp.

Redensyl® acts like a switch: it wakes up hair stem cells

Real hair loss happens when hair stem cells stay asleepin the scalp.
Redensyl® wakes up the hair stem cells to generate a
new growth phase of all the hair

REDENSYL® ACTS AS A MOLECULAR SWITCH TO
TURN ON HAIR GROWTH AGAIN

More information on: http://stemcells.nih.gov

Redensyl®: the secret of patented molecules

GlyZn

DHQG(dihydroquercetin glucoside)

EPIDERMIS

EGCG2(epigallocatehcin gallate glucoside)

Interleukin 8

1. The scalp is soothedto prepare the action of the other molecules

sebaceousgland

Hair stem cells reservoir
DERMIS
sweat gland

Matrix (keratinocytes)
Dermal papilla (fibroblasts)
HYPODERMIS

2. Stem cells are woken up
They migrate down to create a new matrix

3. Hair cells are boosted
They are ready to produce a new hair
4. Zinc and Glycine nourish the matrix
and favor a faster hair growthDHQG: Dihydroquercetin-Glucoside

Origin: Larch tree
MW: 466 g/Mol
Biotechnology optimization (glycosylation)

EGCG2: Epigallocatechin-gallate-Glucoside

Origin: Green tea leaves
MW: 604 g/Mol
Biotechnology optimization (glycosylation)

2x better results than Minoxidil

Hair follicles growth test (Philpott test)
Protocol: 24 hair follicles from men suffering from alopecia were maintained alive with either 1% ofMinoxidil or 1% of Redensyl® during 10 days. Hair growth was measured in µm at D7 and D10.

Hair%growth%in%μm%compared%to%T0%

Hair%growth%a4er%7%and%10%days%+214%**

800"
700"
600"

+118% *

500"
Day"0"

400"
300"
200"

Day"7,"1%"Redensyl®"

100"
0"
D7""

D10"

Control"untreated"

D7""

D10"

Minoxidil®"1%"

D7""

D10"

Neocapyl®"1%"
Redensyl®

*p<0.1, **p<0.001 compared to untreated, Student t-test! Redensyl® increases hair growth by +214% compared to untreated! Redensyl® shows almost two times better results than Minoxidil, thebenchmark reference.

Outstanding clinical results

Clinical assessment
VOLUNTEERS• 26 men aged 18 to 70 years old• Brown to dark hair
• Qualified for a grade 3 to 4 alopecia (Norwoodscale)•With minimum 150 hair/cm2 and 40 telogen hair/
cm2PROTOCOL• Double blind clinical trial versus a placebo• 50% of volunteers received the placebo• 50% received the formula with 3% Redensyl®
• Applying the formula once a day• Under the control of a dermatologist.
• Period of the test: autumn

I!

II!

III!
!!

vertex!

!
IV!

V!

VI!

VII!

III

Clinical formula : AQUA,
ALCOHOL DENAT., BUTYLENE
GLYCOL, GLYCERIN, XANTHAN GUM, DISODIUM EDTA,CITRIC ACID, (+/-) Redensyl® 3%

Increasing growing hair (anagen hair)Protocol: analysis on the volunteers’ scalp of the number of hair in anagen phase

Relaunch%of%growing%(anagen)%hair%%%of%hair%in%anagen%phase%72"+9 % *

70"
68"

NS"

66"
64"
62"
60"
T0"

1"month" 3"months"
Placebo"T0"

1"month" 3"months"
Neocapyl®"3%"
Redensyl®

*p<0.01"compared"to"untreated,"Student’s"tLtest"! Slight non significant placebo effect up to D84 (activation of micro-circulation)! Redensyl® stimulates by +9% hair in anagen phaseReduction of hair loss (telogen hair)Protocol: analysis on the volunteers’ scalp of the number of hair in telogen phase

Reduc@on%of%falling%(telogen)%hair%%%of%hair%in%telogen%phase%38"-17 % *36"
34"

NS"

32"
30"
28"
26"
T0"

1"month" 3"months"
Placebo"T0"

1"month" 3"months"
Redensyl®
Neocapyl®"3%"*p<0.01"compared"to"untreated,"Student’s"tLtest"! Slight non significant placebo effect up to D84 (activation of micro-circulation)! Redensyl® reduces hair in telogen phase by -17%

Visible results in only 84 days
BEFORE

D84

BEFORE

52 years old

46 years old

38 years old

36 years old

42 years old

29 years old

D84

Details - before/after
Analysis"area"L"Day"0"

Criteria#3Age

52 years old% of new anagen hair

+ 10.8%% of density of hair increase+ 17%

Number of new hair / cm2+ 47 hair/ cm2Total number of new hair on the scalp(600 cm2)+ 28,200 hair

Number of new hair per month on thescalp+ 9,400 hair

! Visible redensification of the scalp

BEFORE"
Analysis"area"L"Day"84"AFTER"

Summary of Redensyl® clinical performances

Within 84 days on grade 3 to 4 alopecic volunteers:

85%of volunteers showed clinical improvements:" +9% of anagen hair
" -17% of telogen hair
" +29% of improvement in the anagen/telogen ratio" Hair look thicker" 71% of buying intention" An average +8% increase in hair density" corresponding to +10,000 new hairs" Up to +28,200 new hairsUniquenessBetter results than hair transplantation surgery•

One hair transplantation transplantation = +8,064 new hairs•

65% of the patients undergo a single hair transplantation 1for cost reasons•

But up to 3 hair grafts sessions can be needed to get theappropriate hair density 1•

Redensyl® gives an average:+10,000 new hairs in less than 3 months, with up to+28,200 new hairs

International Society of Hair Restoration Surgery: 2013
Practice Census Results
2 Bernstein Medical center www.bernsteinmedical.com/hairtransplant/follicular-unit-transplantation/graft-numbers/1Redensyl® - examples of product opportunities
MEN•

Hair care (thin hair, hair loss, sparse hair)

WOMEN
•
•

Hair care (damaged hair, hair loss, sparse hair)
Eyelashes growth mascara or primer

HAIR GROWTH TONIC
Hair loss treatment for men
Foam (more easy to apply) which converts
into a lotion
Evaporates quickly – no residues
Application once to twice a day
HAI® : Hair Actives Inside®
HAIR" Redensyl® 1,5%
" Bio-vectorized pro-panthenol (DPTA) 1%

Redensifying – Recharging – Reducing hairthinning - SoothingGROWTHTONIC

ALL DAY HAIR PROTECTION
Women with damaged – thin hairSpray to apply on hair and scalp
Evaporates quickly – nice fragrance
Application in the morning before combing
Hair Beauty Technology:" Redensyl® 2%" Anti ozone (Unicontrozon) 1%" Silicone alternative (Unitamuron) 1%

Protect dyed hair– Prevent hair loss Facilitate combing – Reduce static electricity

All-Day
Hair
Protect

REDENSIFYING SCALP TREATMENT
Men / women with hair loss
Intensive cure to apply on scalp
Favors the massage of the scalp

WEEK 4WEEK 3WEEK 2" Redensyl® 3%" Bio-vectorized panthenol (DPTA) 1%" Sebum control (Unitrienol) 2%

WEEK 1Hair Care Complex:

HYPERCURE_____HAIR TREAMENT

Application everyday

HYPERCURE

Prevention of hair loss – Soothe scalp –Regenerate hair roots – Dynamize hair
growth – Prevent oily hair

EYELASH ENHANCER
Women with sparse eyelashes
Mascara primer
Compatible with all type of make up" Redensyl® 3%" Long lasting, color enhancer, waterproof
booster (Unimer U-1946) 5%
Volumize – Intensify the look – Increase thelength and diameter of eyelashes

EVERLASHES

Application before your mascara

Conclusion

Redensyl®: the cosmetic alternative to hair surgery•••••••

3 years of fundamental research
2 patented molecules (DHQG and EGCG2)
1 green chemistry manufacturing process
1 full set of genetic analysis to decipher themode of action
1 research collaboration with the worldreference laboratory of Dr Philpott
Pharma like purity >95%
Perfectly safety at 100%

! Silver award of the best innovation
ingredient in cosmetics 2014

Redensyl® technical information
INCI :SUGGESTED RANGE OF USE :WATER, GLYCERIN, SODIUM METABISULFITE, GLYCINE, LARIXEUROPAEA WOOD EXTRACT, ZINC CHLORIDE, CAMELLIA SINENSIS
LEAF EXTRACT
1% to 3%

FORMULATION :Add at the end of the formulation process under stirring below 50°C.
Can be heated for a short time with the oil phase of formulation.

SHELF LIFE :> 12 MONTHS - STABILITY TESTS ON GOING

STORAGE:IN A FRIDGE FOR LONG TERM STORAGE
IN A FRIDGE ONCE OPEN
CLEAR YELLOW SOLUTIONTYPICAL
WATER SOLUBLE
1KG, 5 KG AND 25KGSOLVENT FREE (GREEN CHEMISTRY - BIOTECHNOLOGY)

COLOR :ODOR :SOLUBILITY :PACKAGING :OTHER :SAFETY PROFILE

PATCH TEST, NEGATIVE AT 100%
EYE IRRITATION, NEGATIVE AT 100%
AMES TEST, NEGATIVE
HRIPT, NEGATIVE AT 100%
BIODEGRADABLE!

DHQG and EGCG2 are patented molecules from induchem companies

What can we do for you?
www.induchem.com
Induchem AG
Industriestrasse 8A
CH-8604 Volketswil
sales@induchem.com
Induchem USA, Inc.
535 Fifth Avenue, Floor 23
New-York, NY10017
salesusa@induchem.com
Induchem France SAS
171 Bis Avenue Charles de Gaulle
FR-92200 Neuilly Sur Seine
ventes@induchem.com