--------------------------------------------------------------------------------------------------------------------------------------------------------------------MATERIAL SAFETY DATA SHEET
Date Updated: 11/24/2021--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 1 > Product and Company Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------Product Name
DynaMarker Small RNA II Easy Load
(Code# DM197)(Code#)
Component
DynaMarker Small RNA II Easy Load
(Code# DM197)
Loading Buffer PA(Code# DM156)
Company
BioDynamics Laboratory Inc.
Address
9-7 Hongo 2-Chome, Bunkyo-Ku, Tokyo 113-0033 JAPAN
Phone+81-3-5803-9983
Fax+81-3-5684-6270--------------------------------------------------------------------------------------------------------------------------------------------------------------------Evaluated as a single compound below (Formamide)--------------------------------------------------------------------------------------------------------------------------------------------------------------------<2 > Hazards Identification--------------------------------------------------------------------------------------------------------------------------------------------------------------------Classification
Serious eye damage / eye irritation (Category 2B), H320
Reproductive toxicity (Category 1B), H360

Symbol:Signal word: Danger
Hazard statement(s)H320: Causes eye irritation
H360: May damage fertility or the unborn child
Precautionary statement(s)P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy todo - continue rinsing.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P308 + P313: IF exposed or concerned: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental Hazard Statements: none- 1 ver. 1.1

--------------------------------------------------------------------------------------------------------------------------------------------------------------------<3 > Composition/Information on Ingredients--------------------------------------------------------------------------------------------------------------------------------------------------------------------Component:
Component
Code No.
DynaMarker Small RNA II Easy LoadLoading Buffer PA

DM197
DM156

Description of the product: Mixture of substances listed below with nonhazardous additions
Hazardous Ingredient(s)Formamide
CAS #: 75-12-7
Synonym: Methanamide
Percentage:
Component
DynaMarker Small RNA II Easy LoadLoading Buffer PA

Code No.
DM197
DM156

Concentration
60 - 70%
70 - 80%--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 4 > First Aid Measures--------------------------------------------------------------------------------------------------------------------------------------------------------------------Description of first aid measures
General advice:Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled:
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact: Wash off with soap and plenty of water. Consult a physician.
In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed:
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
No data available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 5 > Fire Fighting Measures--------------------------------------------------------------------------------------------------------------------------------------------------------------------Extinguishing media
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture:
No data available
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Further information:
No data available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 6 > Accidental Release Measures--------------------------------------------------------------------------------------------------------------------------------------------------------------------Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into theenvironment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed
containers for disposal.
Reference to other sections: For disposal see section 13.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 7 > Handling and Storage--------------------------------------------------------------------------------------------------------------------------------------------------------------------Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be
carefully resealed and kept upright to prevent leakage.
- 2 ver. 1.1

Recommended storage temperature:- 80 °C
Specific end use(s):No data available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 8 > Exposure Controls / PPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------Engineering controls
Use only in a chemical fume hood. Safety shower and eye bath.
Personal Protective Equipment
Respiratory:
Use respirators and components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use afull-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup toengineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.
Hand:
Compatible chemical-resistant gloves.
Eye:
Chemical safety goggles.
General Hygiene Measures
Wash contaminated clothing before reuse. Wash thoroughly after handling.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 9 > Physical/Chemical Properties (Formamide)--------------------------------------------------------------------------------------------------------------------------------------------------------------------Appearance Form:liquid, clear
Color: colorless
Odor:
Ammonia odor
Odor Threshold:N/ApH:
7.1 (0.5 M)
Melting point/freezing point:
2.55°C (Melting point)
Initial boiling point and boiling range:
210°C
Flash point:
154°C
Evaporation rate:
N/A
Flammability (solid, gas):
N/A
Upper/lower flammability or explosive limits: Upper explosion limit: 19 % (V), Lower explosion limit: 2.7 % (V)Vapour pressure:0.13 kPa at 70.5°C
Vapour density:
1.56 - (Air = 1.0)
Relative density:
1.134 g/cm3 at 25°C
Water solubility:
1000 g/L
Partition coefficient (n-octanol/water):log Pow = -1.51
Auto-ignition temperature:>500°C
Decomposition temperature:154°C
Viscosity:
2.926 mPa.s( 30°C )Explosive properties:
N/A
N/A = not available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 10 > Stability and Reactivity--------------------------------------------------------------------------------------------------------------------------------------------------------------------Stability
Stable: HygroscopicMaterials to Avoid: Bases, Oxidizing agents, Hydrogen peroxide, Iodine, Pyridine, Sulphur oxides
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Ammonia, Hydrogen cyanide
Hazardous Polymerization: No data available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 11 > Toxicological Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------Information on toxicological effects
Acute toxicity (oral):Based on reports that the LD50 value of rats is 3,200 mg / kg, 5,325 mg / kg (SIDS(2013)), and about 6,000 mg / kg (ACGIH (7th, 2001)), it was classified as "Notclassified".
Acute toxicity (Dermal):
Based on a report that the LD50 value of rats is 3,000 mg / kg (SIDS (2013)) and the- 3 ver. 1.1

LD0 value of rabbits is 6,000 mg / kg,> 17,000 mg / kg (ACGIH (7th, 2001)), it wasclassified as "Not classified".
Acute toxicity (Inhalation, gas):
It is a liquid in the definition of GHS.
Acute toxicity (Inhalation, vapor):
Classification not possible due to lack of data.
Acute toxicity (Inhalation, dust-mist):
The rat LC50 value (4 hours) is> 21 mg / L (SIDS (2013)), and the rat LC50 value (6hours) is 3,900 ppm (4 hours converted value: 10.8 mg / L) (ACGIH (7th) , 2001)). Basedon the above results, it was classified as "Not classified". In addition, since all LC50 values
are higher than saturated vapor pressure concentration (2.36 mg / L), the standard value of
mist was applied.
Skin corrosion/irritation:
As a result of irritation test using guinea pig, it has been reported that it was mildly
irritable and recoverable (ACGIH (7th, 2001)). In a skin irritation test in which a stock
solution of this substance was applied to rabbits for 20 hours, mild to moderate erythema
was observed, and skin abrasion was observed 8 days after application. From the results, itis judged to be mild irritant (SIDS (2013)). Based on the above results, it was classified as"Not classified" (Category 3 of UN Classification Standard).
Serious eye damage/eye irritation:
In the eye irritation test using rabbits, all showed mild irritation (SIDS (2013), ACGIH(7th, 2001)). It was classified into Category 2B.
Respiratory/ Skin sensitization:
Respiratory sensitization: Classification not possible due to lack of data.
Skin sensitization: Classification not possible due to lack of data.
Germ cell mutagenicity:
In vivo, negative in the mouse dominant lethal test. Positive in micronucleus test ofmouse bone marrow cells by intraperitoneal administration. Negative in peripheral blood
red cell micronucleus test by gavage for 90 days. Negative in chromosomal aberration testof rat bone marrow cells by subcutaneous administration. (SIDS (2013), NTP DB (Accesson October 2014)). In vitro, negative in reverse mutation test of bacteria, chromosomal
aberration test of cultured mammalian cells. (SIDS (2013), NTP DB (Access on October2014), ACGIH (7th, 2001)). The positive results of the mouse bone marrow cell
micronucleus test were due to high dose intraperitoneal administration (SIDS (2013)), but
the in vitro chromosomal aberration test and the oral peripheral blood micronucleus test
were negative. "Classification not possible" because the data is uncertain.
Carcinogenicity:
Classification not possible due to lack of data.
Reproductive toxicity:
Oral administration (water intake) of a dose (750 ppm (144-226 mg / kg / day)) at
which toxicity (weight gain suppression) was observed in the parent mice also had aneffect on fertility. In addition, in the teratogenicity test after oral administration, skeletal
malformation was observed in the fetus when a dose (198 mg / kg / day) was not observedin the parent mice (SIDS (2013)). Based on the above, it was classified as Category 1B.
Specific target organ toxicity - Single exposure: Classification not possible due to lack of data.
Specific target organ toxicity - Repeated exposure: No data available for humans.
Aspiration hazard:
Classification not possible due to lack of data.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 12 > Ecological Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------Hazardous to the aquatic environment(Acute):72 hours ErC50> 1000 mg / L of algae (Pseudokirkhneriella subcapitata) (Ecologicalimpact test in Environment Agency, 1998). 48 hours EC50> 500 mg / L for crustacea(Daphnia magna) (SIDS, 2013). 96 hours LC50> 100 mg / L of fish (Medaka fish)(Ecological impact test in Environment Agency, 1998). It was classified as "Notclassified" by the above..
(Long-term):
When chronic toxicity data are used, it is rapidly degradable (Degradation degree byDOC after 28 days of degradability test conducted based on OECD TG 301A: 99%(SIDS, 2013). 72 hours NOEC> 10 mg / L of the algae (Pseudokirkhneriella subcapitata)(Ecological Impact Test in Environment Agency, 1998). The above results are classified
as out of category.
Hazardous to the ozone layer:
The substance is classified as "Classification not possible" because it is not listed in theannex to the Montreal Protocol.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 13 > Disposal Considerations--------------------------------------------------------------------------------------------------------------------------------------------------------------------APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION- 4 ver. 1.1

Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 14 > Transport Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------UN number
ADR/RID: - IMDG: - IATA-DGR: UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
Transport hazard class(es)ADR/RID: - IMDG: - IATA-DGR: Packaging group
ADR/RID: - IMDG: - IATA-DGR: Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA-DGR: noSpecial precautions for user
No data available--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 15 > Regulatory Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law concerning Pollutant Release
and Transfer Register / PRTR Law:

Not applicable

Industrial Safety and Health Law,
Substances Subject to be Indicated Names:
Article 57 (Enforcement Order Article 18, Table 9)
Substances Subject to be Notified Names:
Article 57-2 (Enforcement Order Article 18-2, Table 9)
Substances Subject to be Conduct risk assessment: Article 57-3
Chemical Substances Control Law:

Not applicable for Specified Chemical Substance, Monitoring Chemical
Substance and Priority Assessment Chemical Substance.

Fire Service Law:

Group 4: Flammable liquids, Type 3 petroleums Hazardous rank III Water
soluble liquid

Poisonous and Deleterious Substances Control Law:
Not applicable--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 16 > Reference--------------------------------------------------------------------------------------------------------------------------------------------------------------------1) Japan CHEmicals Collaborative Knowledge database2) NITE Chemical Risk Information Platform)
3) THE MERCK INDEX 13TH EDITION
4) UNECE web page (GHS pictograms)--------------------------------------------------------------------------------------------------------------------------------------------------------------------< 17 > Other Information--------------------------------------------------------------------------------------------------------------------------------------------------------------------DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate
safety precautions. It does not represent any guarantee of the properties of the product. Biodynamics Laboratory Inc., shall not be held
liable for any damage resulting from handling or from contact with the above product.
- 5 ver. 1.1