Conference Theme"MONODUKURI" Strategy by Synthetic Organic Chemistry is an academic groupendorsed by The Chemical Society of Japan. This group consists of synthetic organic
chemists of the young generation up to around 40 years old, whose reserach interests arebioorganic chemistry, natural products, chemical biology, functional materials, and novel
methodology for organic synthesis. By gathering these researchers, we aim to develop a
new interdisciplinary area that explores "next-generation manufacturing strategy".

This International Conference is organized by the "MONODUKURI" Group to discuss
among young active researchers from Asian countries the concept of "next-generation
manufacturing strategy" and its applications, in order to transmit this concept to many
research fields and share the scientific information.	  	  	  	  	  	  	  	  	  	  	  	  	 The conference will bring together the scientists from various fields to discuss the following
main topics:
1. Innovative Molecular Transformation
2. High-performance Functional Materials
3. Efficient Synthesis of Natural Products
4. New Aspects in Chemical Biology

Symposium Dates & Venue
Dates
July 17 (Wed) - 19 (Fri), 2013.
Venue
Southern Beach Hotel & Resort OKINAWA
1-6-1 Nishizaki-cho, Itoman, Okinawa 901-0305, Japan.
Tel: +81-98-992-7500
Fax: +81-98-992-7600
http://www.southernbeach-okinawa.com/englishOrganizing Committee
Chairman
Katsunori Tanaka (RIKEN)
Committee members
Kazunobu Igawa (Kyushu University)
Shinya Oishi (Kyoto University)
Hayato Tsuji (The University of Tokyo)
Yoshiaki Nakao (Kyoto University)
Kosuke Namba (The University of Tokushima)
Toshiyuki Hamura (Kwansei Gakuin University)
Go Hirai (RIKEN)
Satoshi Yokoshima (Nagoya University)
Executive committee
Ambara R. Pradipta (RIKEN)
Ayumi Tsutsui (RIKEN)
Akihiro Ogura (RIKEN)
Technical secretariatHitoshi Ohnishi (Prima Tours, Inc.)

Organizer and Supports
Organized by:• The “MONODUKURI” Strategy by Organic Synthesis

Supported by:• The Chemical Society of Japan• Suntory Foundation for Life Sciences• Mizutani Foundation for Glycoscience	 	  	 	  	 	 SuntoryFoundation forLife Sciences

Genera l Information
Lectures- Invited Lecture: 25 min including discussion- Short Oral Presentation: 5 min presentation (no discussion)
Invited Lectures & Short Oral Presentations:
LCD projector is the standard medium for lectures. Power point presentations by using
your own computers are recommended. We appreciate if you could bring your PC andconnect to the switcher during the break before your session. We would ask you to preview
and check your presentations in advance.

Poster Session
Poster presentation is scheduled from 12:15 to 13:50 on July 18. The presenters should
be present during the time for discussion. All posters should be posted before 10:30 on July18, and moved until 16:00 on July 18. A 90 cm width and 180 cm height board will be
prepared for each poster. Materials for attaching posters to the boards will also be provided
at the conference site.

Conference Language
The conference language, written and spoken, will be in English.

BanquetThe conference banquet will be held at 19:15 on July 17 (Wed) at the “Coral West BallRoom” in Southern Beach Hotel & Resort OKINAWA.	 

Program
July 17 (Wednesday)
13:30 - 13:40

Welcome Address
Prof. Katsunori Tanaka (RIKEN)

Session 1<Chairperson: Prof. Takamitsu Hosoya>
13:40 – 14:05
IL-1

Prof. Katsunori Tanaka (RIKEN)“Aza-Electrocyclic Reaction for Visualizing Biomolecules in Live Animals”

14:05 - 14:30
IL-2

Prof. Sunwoo Lee (Chonnam National University)“Transition metal-Catalyzed Coupling Reactions of Propiolic Acids:
Decarboxylative, Carbonylative & Sonogashira Couplings”

14:30 - 14:55
IL-3

Prof. Yao-Ting Wu (National Cheng Kung University)“Bowl-shaped Subunits of C60, C70 and Higher Fullerenes”<Chairperson: Prof. Go Hirai>

14:55 - 15:20
IL-4

Prof. Yoko Saikawa (Keio University)“Synthesis of Ansa-type Natural
Intramolecular Doetz Benzannulation”

15:20 - 15:45
IL-5

Prof. Man Kin Wong (The Hong Kong Polytechnic University)“Synthetic Chemistry for Bioconjugation”

15:45 - 16:10
IL-6

Prof. Wing-Yiu Yu (The Hong Kong Polytechnic University)“Catalytic C-H Bond Cross Coupling Reactions for C-C and C-N Bond
Formations”

16:10 - 16:25

Coffee Break

AntibioticKendomycin

usingSession 2<Chairperson: Prof. Hayato Tsuji>
16:25 - 16:50
IL-7	 

Prof. Toshiyuki Hamura (Kwansei Gakuin University)“Efficient Access to Novel π-Conjugated Compounds Using ReactiveMolecules”

16:50 - 17:15
IL-8

Prof. Huaping Xu (Tsinghua University)“Selenium-containing Polymers: Promising Biomaterials for Controlled
Release”<Chairperson: Prof. Shinya Oishi>

17:15 - 17:40
IL-9

Prof. Sungwoo Hong (Korea Advanced Institute of Science andTechnology)“Rational Design and Efficient Synthesis of Kinase Inhibitors”

17:40 - 18:05
IL-10

Prof. Kazunobu Igawa (Kyushu University)“Reaction Control Using Silyl-substituent
Silylalkenes and Their Ozone Oxidation”

Effects:Synthesisof<Chairperson: Prof. Shuhei Higashibayashi>
18:05 - 18:30
IL-11

Prof. An-Hui Lu (Dailan University of Technology)“Synthesis of Porous Materials with Defined Structure and Morphology
for Adsorption and Catalysis”

18:30 - 18:55
IL-12

Prof. Satoshi Yokoshima (Nagoya University)“Synthesis of Lyconadins A-C”

19:15 - 21:00

BanquetJuly 18 (Thursday)
Session 3<Chairperson: Prof. Kazunobu Igawa>
9:00 - 9:25
IL-13

Prof. Philip Wai Hong Chan (Nanyang Technological University)“Harnessing the Potential of Gold-Catalyzed Alkyne Cycloisomerizationsfor Sustainable Complex Molecule Synthesis”

9:25 - 9:50
IL-14

Prof. Yoshiaki Nakao (Kyoto University)“Intramolecular Oxy- and Aminocyanation of Alkenes by Cooperative
Palladium/Boron Catalysis”	 

9:50 - 10:15
IL-15

Prof. Hsiao-hua (Bruce) Yu (RIKEN)“Molecularly Designed π-Conjugated Polymers as Biomaterials”

10:15 - 10:25

Coffee Break	 <Chairperson: Prof. Katsunori Tanaka>
10:25 - 10:50
IL-16

Prof. Hayato Ishikawa (Kumamoto University)“Three -Step Synthesis of WIN 64821, Ditryptophenaline andNaseseazine B via Bio-inspired Reaction in Water”

10:50 - 11:15
IL-17

Prof. Xuechen Li (The University of Hong Kong)“Protein Chemical Synthesis with Ser/Thr Ligation (STL)”<Chairperson: Prof. Toshiaki Teruya>

11:15 - 12:15
P-2	 

Short Presentation (5 min for each presentation)
Prof. Keisuke Asano (Kyoto University)“Organocatalytic asymmetric oxy-Michael addition
α,β-unsaturated thioester via hemiacetal intermediates”

toγ-hydroxy-P-9

Ms. Kumiko Yamamoto (The University of Tokyo)“Development of Rh-Catalyzed Cross-Aldol-Type Reaction and its
Application to Double-Aldol Reaction”

P-11

Prof. Laurean Ilies (The University of Tokyo)“Iron-Catalyzed C(sp3)–H Bond Activation for Arylation of Aliphatic
Carboxamides”

P-14

Prof. Shuhei Higashibayashi (Institute for Molecular Science)“First Stereoelectronic Effect of Curved Aromatic Structure:
Conformationl Stability of Buckybowl, Substituted Sumanene”

P-17

Prof. Yousuke Yamaoka (Kyoto University)“Efficient Syntheses of Polycyclic Quinolines Using Ynamides Toward
the Total Synthesis of Aplidiopsamine A”

P-20

Prof. Hiroshi Tsuchikawa (Osaka University)“Stereocontrolled synthesis of the 5,5,6-bisspiroacetal ring moiety ofspirolide C”

P-23

Prof. Yoshiyuki Manabe (Osaka University)“Synthetic Study of N-glycans Using Efficient Glycosylation”

P-25

Prof. Yousuke Takaoka (Kyoto University)“Self-assembling turn-on nanoprobes for specific protein detection andimaging”

P-30

Prof. Takamitsu Hosoya (Tokyo Medical and Dental University)“Sequential Triple-Click Reaction by Three Azido-Type SelectiveCycloadditions”

P-33

Dr. Masayuki Tera (Bioorganic Research Institute, Suntory Foundation
for Life Sciences)“Purification of the sesame lignans binding proteins at the germination
stage of Sesamum indicum”

P-36

Dr. Yu Nakagawa (RIKEN)“Solid-state NMR analysis of mannose binding of pradimicin A”

P-41

Prof. Toshiaki Teruya (University of the Ryukyus)“Effects of 14-dien-19-oic acid on the proliferation and differentiation of
osteoblastic MC3T3-E1 cells”

12:15 - 13:50

Lunch & Poster Session

Session 4<Chairperson: Prof. Toshiyuki Hamura >13:50 - 14:15
IL-18

Prof. Toru Amaya (Osaka University)“Catalytic Systems Consisting of Polyanilines and Metal Nanoparticles”

14:15 - 14:40
IL-19

Prof. Yabing Qi (Okinawa Institute of Science and Technology
Graduate University)“Influences of Substrate Temperature on Organic Film Growth ”<Chairperson: Prof. Yoko Saikawa>
14:40 - 15:05
IL-20

Prof. Kosuke Namba (The University of Tokushima)“Organic Chemistry Research on Iron Acquisition in GraminaceousPlants”

15:05 - 15:30
IL-21

Prof. Xiaoguang Lei (National Institute of Biological Sciences)“Complex Natural Products as a Driving Force for Discovery in Organic
Synthesis and Chemical Biology”

15:30 - 15:50

Coffee Break<Chairperson: Prof. Kosuke Namba>

15:50 - 16:15
IL-22	 

Prof. Wenwei Lin (National Taiwan Normal University)“Synthesis of Functional Heteroarenes via Intramolecular Wittig
Reactions”

16:15 - 16:40
IL-23

Prof. Yutaka Ie (Osaka University)“Synthesis, Properties, and n-Type Performances of Electronegative
π-Conjugated Systems”

16:40 - 17:05
IL-24

Prof. Shinya Oishi (Kyoto University)“Development of Novel Kinesin Spindle Protein (KSP) Inhibitors”

17:15 - 19:00

Beach Barbecue (Discussion Time)

July 19 (Friday)

Session 5<Chairperson: Prof. Yoshiaki Nakao>
09:00 - 09:25
IL-25

Prof. Hsyueh-Liang Wu (National Taiwan Normal University)“Bicyclo[2.2.1] Chiral Dienes in the Rh-Catalyzed 1,4-Addition Reactions”

09:25 - 09:50
IL-26

Prof. Hayato Tsuji (The University of Tokyo)“Carbon-Bridged Oligo(Phenylenevinylene)s: Their Unique Propertiesand Application to Dye-sensitized Solar Cells”

09:50 - 10:05

Coffee Break<Chairperson: Prof. Satoshi Yokoshima>

10:05 - 10:30
IL-27

Prof. Guangxin Liang (Nankai University)“New Entry into the Fischer Indole Synthesis and Its Applications in the
Total Synthesis of Indole Alkaloids”

10:30 - 10:55
IL-28

Prof. Go Hirai (RIKEN)“Fluorine Containing C-linked Gangliosides Analogue”

10:55 - 11:20
IL-29

Prof. Richard P. Cheng (National Taiwan University)“Effect of Arginine Side Chain Length: Structure and Function”

11:20 - 11:30

Closing Remarks

11:30 -(Optional Tour)	 

- Poster Session -P-1

Masahiro Yoshida, Miki Shibata, Kosuke Namba (The University ofTokushima)“Palladium-catalyzed
unusualcascade
cyclizationof
4-hydroxy-2-pyrones with allylic bisacetates”

P-2

Keisuke Asano, Takaaki Okamura, Seijiro Matsubara (KyotoUniversity)“Organocatalytic asymmetric oxy-Michael addition to γ-hydroxyα,β-unsaturated thioester via hemiacetal intermediates”

P-3

Suguru Matsuoka1, Toshiyuki Hamura1, Kazunobu Igawa2,Katsuhiko Tomooka2 (Kwansei Gakuin University1, Kyushu University2)	 
“Study on the Synthesis of Planar Chiral (1,10)Anthracenophane
Derivatives”

P-4

Kazunobu Igawa, Daisuke Yoshihiro, Nobumasa Ichikawa, Naoto
Kokan, Katsuhiko Tomooka (Kyushu University)“Enantioselective Synthesis of Alkenylhydrosilane: DesymmetricHydrosilylation of Dihydrosilane”

P-5

Tomoe Kato, Yuto Sumida, Takamitsu Hosoya (Tokyo Medical andDental University)“Generation of Arynes via Ate Complexes of Arylboronic Esters with an
ortho-Leaving Group”

P-6

Yuto Sumida, Ryu Harada, Takamitsu Hosoya (Tokyo Medical andDental University)“An Efficient Synthetic Method of Dibenzoxaborins and Application to theConcise Synthesis of Defucogilvocarcin M”

P-7

Shinya Shiomi, Daisuke Ushijima, Rie Nakashima,Hanamura, Hayato Ishikawa (Kumamoto University)“Synthetic Study of Geissoschizal and Geissoschizine”

P-8

Takayuki Iwata1,2, Koichi Fukase2, Katsunori Tanaka1 (RIKEN1,Osaka University2)“One-Pot Synthesis of 2-Aminoimidazole Natural Products: Inspired byArginine Post-Translational Modification”

P-9

Kumiko Yamamoto, Luqing Lin, Shigeki Matsunaga, Motomu Kanai(The University of Tokyo)“Development of Rh-Catalyzed Cross-Aldol-Type Reaction and its
Application to Double-Aldol Reaction”	 

SatsukiP-10

Kazuhisa Hirabayashi1, Yuko Toki1, Toshio Takayanagi2, Tetsuo
Nagano3, Kenjiro Hanaoka1 (The University of Tokyo, Graduate Schoolof Pharmaceutical Sciences1; The University of Tokushima2; The
University of Tokyo, Open Innovation Center for Drug Discovery3)“Chemical Equilibrium of Si-substituted Fluorescein and its Application toRed Fluorescent Probes”

P-11

Laurean Ilies (The University of Tokyo)“Iron-Catalyzed C(sp3)–H Bond Activation for Arylation of AliphaticCarboxamides”

P-12

Ambara R. Pradipta, Katsunori Tanaka (RIKEN)“Discovery of [4+4] & [4+2] Reactions of Unsaturated Imines andApplication to Alkaloids Synthesis”

P-13

Shodai Takahashi1, Tetsuo Nagano2, Kenjiro Hanaoka1 (The
University of Tokyo, Graduate School of Pharmaceutical Sciences1; The
University of Tokyo, Open Innovation Center for Drug Discovery2)“Development of a Reversible Off-on Fluorescence Probe for Hypoxia
and Imaging of Hypoxia-Normoxia Cycles in live cells”

P-14

Shuhei Higashibayashi (Institute for Molecular Science)“First Stereoelectronic Effect of Curved Aromatic Structure:
Conformationl Stability of Buckybowl, Substituted Sumanene”

P-15

Kenji Sugimoto, Kazuki Toyoshima, Shiori Nonaka, Kenta Kotaki,Hirofumi Ueda, Hidetoshi Tokuyama (Tohoku University)“Protecting-Group-Free Total Synthesis of (–)-Rhazinilam and(–)-Rhazinicine using Gold-Catalyzed Cascade Cyclization”

P-16

Hitoshi Tamiaki1, Nobutaka Ariki1,2, Tomohiro Miyatake2(Ritsumeikan University1, Ryukoku University2)“Physical and Chemical Properties of Synthetic Chlorophyll Derivatives
Possessing Various 3- and 20-Substituents”

P-17

Yousuke Yamaoka, Takahiro Yoshida, Ken-ichi Yamada, Kiyosei
Takasu (Kyoto University)“Efficient Syntheses of Polycyclic Quinolines Using Ynamides Toward
the Total Synthesis of Aplidiopsamine A”

P-18

Masahiro Yoshida, Shota Yodokawa, Hironobu Takai, Kozo
Shishido, Kosuke Namba (The University of Tokushima)“Regio- and Diastereoselective Oxidative Radical Cyclization of Cyclic
β-Keto Ester with Alkenes”

P-19

Wen Piao1, Tetsuo Nagano2, Kenjiro Hanaoka1 (The University ofTokyo, Graduate School of Pharmaceutical Sciences1; The University ofTokyo, Open Innovation Center for Drug Discovery2)“Development of Azo-based Fluorescence Probes to Detect Hypoxia”	 

P-20

Hiroshi Tsuchikawa, Tomohiro Wakisaka, Yoshifumi Yasukawa,
Michio Murata (Osaka University)“Stereocontrolled synthesis of the 5,5,6-bisspiroacetal ring moiety ofspirolide C”

P-21

Kohei Takeuchi, Yukari Kaihara, Kosuke Namba, Keiji Tanino(Hokkaido University)“Synthetic Studies on Palau’amine”

P-22

Shohei Eda, Hiroshi Haneda, Masato Aratani, Toshiyuki Hamura(Kwansei Gakuin University)“Efficient Access to Substituted Pentacene Derivatives by Successive
Cycloaddition of Isobenzofurans”

P-23Yoshiyuki Manabe1, Jiazhoui Zhou1, Masahiro Nagasaki1, Naoya
Minamoto1, Katsunori Tanaka1,2, Koichi Fukase1 (Osaka University1,RIKEN2)“Synthetic Study of N-glycans Using Efficient Glycosylation”

P-24

Masahiro Yoshida, Tomotaka Mizuguchi, Kosuke Namba (TheUniversity of Tokushima)“Synthesis of substituted pyridines by a ring opening–cyclization reactionof propargylic aziridines”

P-25

Yousuke Takaoka, Itaru Hamachi (Kyoto University)“Self-assembling turn-on nanoprobes for specific protein detection andimaging”

P-26

Masahiro Yoshida, Tomoyo Kasai, Kosuke Namba (The University ofTokushima)“Enantioselective Total Synthesis of HM-3”

P-27

Ching-Yuan Liu1,2, Hui Chong1, Hsing-An Lin1,3, Yoshiro
Yamashita3, Hsiao-hua Yu1 (RIKEN1, National Central University2,
Tokyo Institute of Technology3)“Pd-Catalyzed Direct C-H Arylations of Dioxythiophenes Bearing
Reactive Functional Groups: A Step-Economical Approach for
Functional π-Conjugated Oligoarenes”

P-28

Masahiro Yoshida, Shoko Ohno, Kosuke Namba (The University ofTokushima)“Palladium-catalyzed cascade nucleophilic substitution–[2+2] cyclizationof propargylic esters with 2-vinylphenols”

P-29

Ryota Nabika, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii (KyotoUniversity)“Synthetic Studies on Coibamide A”	 

P-30

Takamitsu Hosoya, Suguru Yoshida, Kimiyuki Kanno, Isao Kii,
Takeshi Matsushita, Masatoshi Hagiwara (Tokyo Medical and DentalUniversity)“Sequential Triple-Click Reaction by Three Azido-Type SelectiveCycloadditions”

P-31

Eisuke Ota1,2, Marie Kato1, Kana Oonuma1,3, Go Hirai1,3, Shigeru
Nishiyama2, Mikiko Sodeoka1,3,4 (RIKEN, Synthetic Organic Chemistry
Laboratory1, Keio University2, RIKEN Center for Sustainable ResourceScience3, ERATO-JST4)“Development of Molecular Probes Based on a Sialidase-resistantGanglioside GM3 Analogue”

P-32

Hidenori Okamura, Yosuke Taniguchi, Shigeki Sasaki (KyushuUniversity)“N-(Guanidinoethyl)-2’-deoxy-5-methylisocytidine
exhibits
selective
recognition of the CG inversion site for the formation of anti-parallel
triplex DNA”

P-33

Masayuki Tera1, Jun Murata1, Yasuaki Kabe2, Manabu Horikawa1(Bioorganic Research Institute, Suntory Foundation for Life Sciences1,Keio University2)“Purification of the sesame lignans binding proteins at the germination
stage of Sesamum indicum”

P-34

Yosuke Taniguchi, Shigeki Sasaki (Kyushu University)“Inhibition of the Cell Proliferation Using Triplex Forming
Oligonucleotides Containing a W-shaped Nucleoside Analogues(WNA-βT)”

P-35

Akihiro Ogura1, Satoshi Yokoshima2, Tohru Fukuyama2 (RIKEN1,Nagoya University2)“Synthetic Studies on Yuzurimine”

P-36

Yu Nakagawa1, Takashi Doi2, Takara Taketani1, Kiyonori
Takegoshi2, Yasuhiro Igarashi3, Yukishige Ito1,4 (1RIKEN, 2Kyoto
University, 3Toyama Prefectural University, 4JST·ERATO)“Solid-state NMR analysis of mannose binding of pradimicin A”

P-37

Yu Kushida1, Tetsuo Nagano2, Kenjiro Hanaoka1 (The University ofTokyo, Graduate School of Pharmaceutical Sciences1; The University ofTokyo, Open Innovation Center for Drug Discovery2)“Development of a Red Fluorescence Probe for Protease Activity Basedon Changes in Spectral Properties”

P-38

Ayumi Tsutsui, Rie Imaki, Shinobu Kitazume, Naoyuki Taniguchi,
Katsunori Tanaka (RIKEN)“[4+4] Cycloaddition of Polyamine-Derived Unsaturated Imines and Their
Biological Functions”	 

P-39

Kazunobu Igawa, Kouhei Machida, Kazuhiro Uehara, KatsuhikoTomooka (Kyushu University)“Synthesis and Stereochemistry of [7]Orthocyclophane”

P-40

Aiki Hiza (University of Shizuoka)“Practical Synthesis of Nobiletin and its PET Imaging Study”

P-41

Toshiaki Teruya, Miki Yamada, Kosuke Sueyoshi (University of theRyukyus)“Effects of 14-dien-19-oic acid on the proliferation and differentiation ofosteoblastic MC3T3-E1 cells”