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Product Name: Cholesterol esterase (COE-313)
First issue : May. 1. 2014
Revised: May. 31. 2022
SDS No.1018F

Safety Data Sheet
1 Chemical Product and Company Identification
Identification of the productProduct CodeSupplierName
Address

Cholesterol esterase
COE-313TOYOBO CO., LTD.
Osaka Umeda Twin Towers South,
1-13-1 Umeda Kita-ku, Osaka 530-0001, Japan

Department
Phone+81-6-6348-3846
Fax+81-6-6348-3833
Recommended use and restrictions on use diagnostic product2 Hazard Identification
Most Important Hazards and Effects
GHS classification

3Composition/Information on Ingredients
Substance/Mixture
Chemical Nature
CAS#Concentration or concentration range
Stabilizer, etc
Ingredients Contributing to the Hazard
Common Chemical nameConcentration or concentration range
Chemical formula
CAS#4

The product might cause allergic reactions uponinhaling or skin contact because of the protein
Classification not possible

MixtureCholesterol esterase
9026-00-0
ca. 24%ca. 76%Polyethylene Glycol-p-octylphenyl Ether (Triton X-100)
ca 0.3% (W/W)
C8H17-C6H4O(C2H4O)nH
9002-93-1

First Aid Measures
Inhalation
Skin Contact
Eye Contact
Ingestion

Remove to fresh air. Consult a physician whenunpleasantness occurs.
Wash off with plenty of water. Consult a physician when
inflammation on the skin occurs.
Wash off with running water for several minutes orlonger immediately, consult a physician afterwards.
Swill plentiful amount of water or milk for immediate
vomiting, consult a physician.

5 Fire Fighting Measures
Extinguishing Media
Protection of Firefighters

Water spray, dry chemical powder, or carbon dioxide etc.
Avoid working at leeward.

6 Accidental Release Measures
Personal Precautions
Environmental Precautions
Methods for Cleaning upWear protective gear to avoid eye/skin contact andinhalation. Do not work at leeward.
High concentrated waste fluid should not be directly
discharged into rivers.
Use cloth, paper or anything similar to soak up thesolution leaking out of the container. Take up undervacuum using dust collecting filter, wash residual
spill with copious amounts of water.(Waste water shouldbe treated with activated sludge etc.)

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Product Name: Cholesterol esterase (COE-313)
First issue : May. 1. 2014
Revised: May. 31. 2022
SDS No.1018F

Safety Data Sheet
7 Handling and StorageHandlingTechnical Measures
Precautions
Safe Handling Advice

StorageTechnical Measures
Incompatible Products
Storage Conditions
Packaging Materials

Wear protective gear to avoid eye/skin contact andinhalation. Do not drop the container to prevent thecontent popping out.
None specified.
Wear protective gear, avoiding contact on eye,skin andcloths.

Keep sealed container in freezer.
None specified.
Store under -20℃.
Use the initial container of the product.

8 Exposure Controls/Personal Protection
Engineering Measures
Personal Protective Equipment
Respiratory Protection
Hand Protection
Eye Protection
Skin and Body Protection

Set local ventilation equipment.
Protecting mask.
Protecting gloves(rubbers or plastic gloves etc.).
Safety goggles.
Long sleeve working wear.

9 Physical and Chemical Properties
Physical StateColour/Odour
pHDecomposition Temperature
Flash Point
Density
Solubility

PowderLight brown/No odour
Approximate pH7.5 in the case of 10 mg/ml in water.
No information available.
No information available.
No information available.
Easily soluble in water.

10 Stability and Reactivity
Stability
Possible hazard reactions at specificcondition
Conditions to avoid
Materials to avoid
Hazardous Decomposition Products

Stable at temperatures below -20℃. Proteins, when left
for long at room temperature, might be degraded, which
does not cause any hazardous reaction though.
Not specified.
Prolonged storage under higher temperature thanroom temperature and high humidity.
Any materials which dissolve or destroy proteins suchas strong acid or alkali.
No information available.

11 Toxicological Information
Acute Toxicity
Skin corrosion/irritation
Eye damage/irritation
Sensitization
Germ cell mutagenicity
Carcinogenicity
Toxic to reproduction
Specific target organ toxicity(Single exposure)Specific target organ systemic toxicity(Repeated exposure)

It is considered that acute toxicity is extremely low.
No information available.
No information available.
Might cause allergic reactions upon inhaling or skincontact because of the protein contained.
No information available.
No information available.
No information available.
No information available.
No information available.

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Product Name: Cholesterol esterase (COE-313)
First issue : May. 1. 2014
Revised: May. 31. 2022
SDS No.1018F

Safety Data Sheet
Aspiration toxicity

No information available.

12 Ecological Information
Acute hazards to the aquatic environment
Persistence /Degradability

Polyethylene Glycol-p-octylphenyl Ether (Triton X-100)
LC50/96hr = 3mg/L (bluegill)
Not rapidly biodegradable substance: 22% by BOD (NationalInstitute of Technology and Evaluation, Japan)
Enzyme and other organic ingredients are biodegradable anddoes not remain on the environment for long.

13 Disposal Considerations
Waste from Residues
Contaminated packaging

Dispose of protein in accordance with all applicable
local and national laws and regulations.
Wash with copious amounts of water and waste conforming
to local regulations depending on the type of the14 Transport Information
International Regulations
Specific Precautions

None specified (Not classified as hazardous material as
per the UN recommendation).
Keep at temperatures below -20℃.

15 Regulatory Information
REACH(EU)Regulations

SVHC：Polyethylene Glycol-p-octylphenyl Ether(Triton X-100)
Follow all of laws and regulations in your country.

16 Other Information
Notice

The contents specified here is made based on thedocuments, information or data which are currently
available and subject to revision in the future. TOYOBO
makes no warranty and assumes no liability whatsoeverin connection with any use of this information.