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Olink® Target 受託サービス

1 µL 〜

Olink® Target を用いた 血清 血漿 タンパク質相対定量解析

質量分析で到達できない領域へアプローチ。

微量のリキッドバイオプシーサンプルから Low-abundant protein を定量。
Proximity Extension Assay, PEA 法は、ターゲットのタンパク質に対し、2 つの DNA タグ付き抗体でイムノアッセイを行い、得られた 2 本鎖 DNA からリアルタイム PCR や次世代シーケンサーで発現定量を行う革新的な技術です。ターゲットタン
パク質に特異的な 2 つの抗体が正しく結合した場合のみ、2 本鎖 DNA が形成されるため、極めて特異性の高いアッセイ
技術であり、マルチプレックス反応における抗原と抗体の交差反応性の問題を克服しています。
質量分析を用いたプロテオーム解析の場合、特に血清・血漿のように複雑性が高くて含まれるタンパク質の濃度差が大きい検体では、多量タンパク質によって微量タンパク質の検出や定量が妨げられる事も多く、例えば、サイトカイン類に代表されるような微量タンパク質は、バイオマーカー探索や疾患研究において大変重要であるにもかかわらず、検出できないケースが多くあります。今回、新たに受託サービスをスタートいたします、Olink proteomics 社のプラットフォー
ム（PEA 法）では、このような極微量に含まれるタンパク質も精度よく比較定量する事ができ、質量分析を用いた方法

Dynamic concentration range

では到達できなかった領域へのアプローチが期待できます。

Classical plasma proteins

Tissue leakage proteinsLow-abundant proteins

IL-6, IL-8,
INFγ, TNFα

Circulating plasma proteins

Olink PEA テクノロジーの特徴
Olink Target 96

受託サービスの特徴と仕様 ・・・ 4

Olink Target 96 パネルのご紹介
Olink Target 48

・・・ 2
・・・ 5

受託サービスの特徴と仕様 ・・・ 14

Olink Target 48 パネルのご紹介

・・・ 15pg/ml

Olink® PEA テクノロジーの特徴― Proximity Extension Assay―

1 つのタンパク質に対し、2 つの DNA タグ付き抗体でイムノアッセイを行い、得られた 2 本鎖 DNA からリアルタイム PCR や次世代シーケンサーで発現定量を行う技術です。ターゲットタンパク質に特異的な 2 つの抗体が正しく結合した場合のみ、2 本鎖 DNA が形成されるため、極めて特異性の高いアッセイ技術であり、マルチプレックス反応における抗原と抗体の交差反応性の問題を克服しています。

Immuno reaction
ターゲットタンパク質につき、2種類の抗体が選定され、相補的な配列のDNAオリ

ゴヌクレオチドで標識されています。

これらのオリゴ標識抗体が、溶液中にてターゲットタンパク質に結合します。

Antibody①-1Protein ①

Antibody①-2

Protein ②

Protein ③

Extension reaction

2つの抗体が近接すると、それらに結合している相補的なDNAオリゴヌクレオ
チドがハイブリダイズします。

Ampliﬁcation
それぞれのターゲットタンパク質に特有の配列である2本鎖DNAが、初期濃度に比例して生成されます。

Detection by qPCR

96 アッセイアプライエリア

96 サンプルアプライエリア

microﬂuidic qPCRによって、定量化

されます。

9,216
PCR 反応槽

Data generation and QC
専用の解析ソフトウェアにデータをインポートし、データ品質の検証、データノ

ーマライズを行います。また、Olink®

Insights Stat Analysisで統計解析を実施できます。

Olink® NPX Signature

データ解析 Olink® Insights Stat Analysis

マルチプレックス抗体反応における “交差反応性” の問題を解決

マルチプレックス ELISA

PEA 法

交差反応により生じた非特異的産物もシグナルとして検出され、濃度が過剰・過少評価される場合がある。

交差反応により生じた非特定的産物では、二本鎖 DNA が形成されないため、リアルタイム PCR シグナルとして検出されない。そのため、より多くのマルチプレックス反応を、精度よく行う事が可能。

微量サンプルからでも数多くのタンパク質を測定可能
マイクロフリューディクス技術により、1 パネル（Target 96 の場合、92 タンパク質の測定）に必要な血漿はたった 1uL。
複数パネルを活用すれば、より多くのタンパク質をカバーできます。
Target 96 で 最大 1,161 タンパク質をカバー（13 パネル使用時。サンプル量はわずか 13 uL ）透明性のあるバリデーションデータ
アッセイ開発時におけるバリデーション結果が公開されています。

・感度

検出限界（LOD）、定量幅（LLOQ、ULOQ）、Hook 効果点の算出

・特異性

交差反応性の確認

・再現性

同時再現性（Intra CV）および日差再現性（Inter CV）の算出

・スケーラビリティ

マルチプレックス数を変化させた時の相関試験

・ダイナミックレンジ

組換えタンパク質を用いた定量幅の算出

厳密なデータ品質管理
Olink Proximity Extension Assay（PEA）は、複数のコントロールを使用し、全工程によって問題が生じていない事が厳密にチェックされます。

内部標準

各ステップごとに内部標準が設定されており、これらがバラつきなく測定できるかモニタリングします。

外部標準

Immuno controls
IMMUNO REACTION

GFP

非ヒト抗原（phycoerythrin と GFP）
2 種類とそれらに結合する各 2 つの抗体です。PEA のすべてのステップに問題がないか評価できます。

Sample control (x2）

ヒト血漿 (pooled)⇒ intra/ inter CV 値を算出

Negative control (x3）

標準的なバッファー⇒ 検出限界 (LOD) の算出

3 種類 ( 計 4 つ ) の内部標準を全ウェルにスパイクイン

Interplate control (x3）PE
Extension control
EXTENSION REACTION

オリゴペアが結合した
抗体 92 種類
⇒ ラン内・間のノーマライズ

内部標準

…

マッチするオリゴペアが IgG
抗 体 に 結 合 さ れ た も の で、DNA タグは常に近接しています。伸長反応、増幅、検出のステップの評価に使用されます。また、データのノーマライズにも使用されます。

PRE-AMPLIFICATION
1

Ampliﬁcation/Detection control
Detection by qPCR

ステップの評価に使用されます。

閾値を満たさない
データポイント

0.3
NPX

合成 2 本鎖 DNA です。増幅、検出の

0.5

0

-0.3
-0.5

-1

品質管理（例）
設定基準を満たさないデータポイントが明確に判定されます。

Olink Target 96 受託サービス■ 相対定量値 (Normalized Protein Expression, NPX)
■ 1 つのパネルにつき、96 のアッセイが実施されます。
┗ 92 種のターゲットアッセイと、4 種のコントロールアッセイから構成。
■ 1 つのパネルにつき、最大 88 サンプルの測定が可能。
■ 血清・血漿・脳脊髄液、唾液など幅広いサンプル種に対応。
■ 必要なサンプル量は血漿の場合 1uL

■ パネルは全 15 種類（ヒト 14 種類、マウス 1 種類） ≪下記参照≫

血清・血漿、脳脊髄液、唾液、尿組織・細胞ライセート液、培養上清等

Olink Target 96 panel の種類

ヒト用 14 種類 ／ マウス用 1 種類

96 サンプル┗ 88 サンプル┗ 8 コントロール

×┗ 疾患領域ごとに構成されたパネル（7 種類）
Inﬂammation
Cardiovascular 2 種類
Oncology 2 種類
Neurology
Immuno-oncology

96 アッセイ┗ 92 ターゲット┗ 4 QC 用┗ 生物学的プロセスごとに構成されたパネル
Cardiometabolism
Cell regulation
Neuro-exploratory
Immune response
Development
Metabolism
Organ damage

88 検体を同時測定し、92 の対象タンパク質についての『相対定量値』算出。

仕各パネルのアッセイ対象タンパク質詳細は次ページから様▶ 必要サンプル量▶価格

血清・血漿の場合、20uL 以上をご提供ください。

基本料金￥500,000（税別）／ パネル

その他の検体（脳脊髄液、唾液、尿、細胞ライセート液等）

分析単価￥20,000（税別）／ 検体の場合は、ご相談ください。

▶ 納期
分析サンプルをお受け取りした日から1.5〜2ヶ月程度（使用するパネルによって異なりますので、お問い合わせください）▶ サービス内容

・サンプル前処理┗ 96ウェルフォーマットへの分注作業┗ サンプル ランダマイゼーション
・Olink Target 96 分析
・専用ソフトウェアでの一次解析

▶ 納品物

・報告書
・データ
（エクセルファイル形式）

例）2群 × 各 n=30 の場合￥500,000 ＋ ￥20,000×60 = ￥1,700,000
・多検体の場合、割引適応あり
・弊社（国内拠点）での分析のため、サンプル輸送費は〜2,000円程度です。
一般の宅配【冷凍便・ドライアイス梱包】でお送りください。

・分析遂行の最小検体数は44検体以上とさせて頂いております。
44検体以上未満でご依頼の場合には、別のユーザー様案件とのパネルシェアをお待ち頂く、または、44検体分の費用をご負担いただく事をお願いたします。

★ 詳しくはこちらからお問合せください！

◇ Inﬂammation「炎症」は生物医学研究にとって中心的な重要性を持つ生物学的プロセスであり、“古典的な” 炎症状態（IBD や皮膚疾患など）から心血管疾患や癌まで幅広い疾患の要因であると考えられています。このパネルは、関節リウマチ、クローン病、潰瘍性大腸炎、神経炎症、呼吸器疾患などのさまざまな疾患領域で、炎症関連バイオマーカーとされるタンパク質が分析対象となります。

Olink Target 96 inﬂammation
TargetAdenosine Deaminase (ADA)
Artemin (ARTN)
Axin-1 (AXIN1)
Beta-nerve growth factor (Beta-NGF)
Caspase 8 (CASP-8)
C-C motif chemokine 4 (CCL4)
C-C motif chemokine 19 (CCL19)
C-C motif chemokine 20 (CCL20)
C-C motif chemokine 23 (CCL23)
C-C motif chemokine 25 (CCL25)
C-C motif chemokine 28 (CCL28)
CD40L receptor (CD40)
T-cell surface glycoprotein CD8 alpha chain (CD8A)
CUB domain-containing protein 1 (CDCP1)C-X-C motif chemokine 1 (CXCL1)C-X-C motif chemokine 5 (CXCL5)C-X-C motif chemokine 6 (CXCL6)C-X-C motif chemokine 9 (CXCL9)C-X-C motif chemokine 10 (CXCL10)
C-X-C motif chemokine 11 (CXCL11)
Cystatin D (CST5)
Delta and Notch-like epidermal growth factor related receptor (DNER)
Eotaxin-1 (CCL11)
Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1)
Fibroblast growth factor 5 (FGF-5)
Fibroblast growth factor 19 (FGF-19)
Fibroblast growth factor 21 (FGF-21)
Fibroblast growth factor 23 (FGF-23)
Fms-related tyrosine kinase 3 ligand (FIt3L)
Fractalkine (CX3CL1)
Glial cell line-derived neutrophic factor (hGDNF)
Hepatocyte growth factor (HGF)
Interferon gamma (IFN-gamma)
Interleukin-1 alpha (IL-1 alpha)Interleukin-2 (IL-2)
Interleukin-2 receptor subunit beta (IL-2RB)
Interleukin-4 (IL-4)
Interleukin-5 (IL-5)
Interleukin-6 (IL-6)
Interleukin-7 (IL-7)
Interleukin-8 (IL-8)
Interleukin-10 (IL-10)
Interleukin-10 receptor subunit alpha (IL-10RA)
Interleukin-10 receptor subunit beta (IL10RB)
Interleukin-12 subunit beta (IL-12B)
Interleukin-13 (IL-13)

Uniprot No.
P00813
Q5T4W7O15169
P01138Q14790
P13236
Q99731
P78556P55773
O15444
Q9NRJ3
P25942
P01732
Q9H5V8
P09341
P42830
P80162
Q07325
P02778O14625
P28325Q8NFT8
P51671
Q13541
P12034
O95750Q9NSA1Q9GZV9P49771
P78423
P39905
P14210
P01579P01583P60568P14784
P05112P05113
P05231
P13232
P10145
P22301
Q13651
Q08334
P29460
P35225

TargetUniprot No.

Interleukin-15 receptor subunit alpha (IL-15RA)
Interleukin-17A (IL-17A)
Interleukin-17C (IL-17C)
Interleukin-18 (IL-18)
Interleukin-18 receptor 1 (IL-18R1)
Interleukin-20 (IL-20)
Interleukin-20 receptor subunit alpha (IL-2oRA)
Interleukin-22 receptor subunit alpha-1 (IL-22RA1)
Interleukin-24 (IL-24)
Interleukin-33 (IL-33)
Latency-associated peptide transforming growth factor beta 1 (LAP TGF-beta-1)
Leukemia inhibitory factor (LIF)
Leukemia inhibitory factor receptor (LIF-R)
Macrophage colony-stimulating factor 1 (CSF-1)
Macrophage inﬂammatory protein 1-alpha (MIP-1 alpha)Matrix metalloproteinase-1 (MMP-1)
Matrix metalloproteinase-10 (MMP-10)
Monocyte chemotactic protein 1 (MCP-1)
Monocyte chemotactic protein 2 (MCP-2)
Monocyte chemotactic protein 3 (MCP-3)
Monocyte chemotactic protein 4 (MCP-4)
Natural killer cell receptor 2B4 (CD244)
Neurotrophin-3 (NT-3)
Neurturin (NRTN)
Oncostatin-M (OSM)
Osteoprotegerin (OPG)
Programmed cell death 1 ligand 1 (PD-L1)
Protein S100-A12 (EN-RAGE)
Signaling lymphocytic activation molecule (SLAMF1)
SIR2-like protein 2 (SIRT2)
STAM-binding protein (STAMPB)
Stem cell factor (SCF)
Sulfotransferase 1A1 (ST1A1)
T-cell surface glycoprotein CD5 (CD5)T-cell surface glycoprotein CD6 isoform (CD6)
Thymic stromal lymphopoietin (TSLP)
TNF-beta (TNFB)
TNF-related activation cytokine (TRANCE)
TNF-related apoptosis ligand (TRAIL)
Transforming growth factor alpha (TGF-alpha)Tumor necrosis factor (Ligand) superfamily member 12 (TWEAK)
Tumor necrosis factor (TNF)
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
Urokinase-type plasminogen activator (uPA)
Vascular endothelial growth factor A (VEGF̲A)

Q13261
Q16552
Q9P0M4
Q14116
Q13478Q9NYY1
Q9UHF4
Q8N6P7
Q13007
O95760
P01137
P15018
P42702
P09603
P10147
P03956
P09238
P13500P80075
P80098
Q99616Q9BZW8P20783
Q99748P13725O00300Q9NZQ7
P80511
Q13291Q8IXJ6
O95630
P21583
P50225
P06127
P30203
Q969D9P01374
O14788
P50591
P01135
O43508
P01375
O43557
Q07011
P00749P15692▶ 納品データ例
各ターゲットタンパク質について、相対定量値 (Normalized Protein Expression, NPX) を報告します。

・・・ 92
ターゲット
タンパク質

Assay name
Uniprot ID
Unique Olink ID

NPX値(比較定量値)・・・〜 88 検体/ パネル◇ CardiovascularⅡ（CVDⅡ）、CardiovascularⅢ（CVDⅢ）
既知の心血管疾患マーカー、炎症マーカー、および新しい CVD マーカー候補と考えられる探索的ヒトタンパク質が分析対象となるパネルです。
ⅡとⅢの対象タンパク質は完全に異なっており、2 つのパネルで 184 種類のタンパク質がカバーできます。

Olink Target 96 CardiovascularⅡ
TargetUniprot No.

Q166982,4-dienoyl-CoA reductase, mitochondrial (DECR1)
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS13) Q76LX8
P35318ADM (ADM)
O00253
Agouti-related protein (AGRP)
P35475Alpha-L-iduronidase (IDUA)
Q15389Angiopoietin-1 (ANG-1)
Q02763
Angiopoietin-1 receptor (TIE2)Q9BYF1
Angiotensin-converting enzyme 2 (ACE2)
P22004
Bone morphogenetic protein 6 (BMP-6)
Q9BWV1
Brother of CDO (Protein BOC)
P35218Carbonic anhydrase 5A, mitochondrial (CA5A)
Carcinoembryonic antigenrelated cell adhesion molecule 8 (CEACAM8) P31997
P07711Cathepsin L1 (CTSL1)
Q92583C-C motif chemokine 17 (CCL17)P10147C-C motif chemokine 3 (CCL3)
P29965
CD40 ligand (CD40-L)
Q99895Chymotrypsin C (CTRC)
P09341C-X-C motif chemokine 1 (CXCL1)
P07585
Decorin (DCN)
O94907
Dickkopf-related protein 1 (Dkk-1)
P12104
Fatty acid-binding protein, intestinal (FABP2)Q9NSA1
Fibroblast growth factor 21 (FGF-21)
Q9GZV9Fibroblast growth factor 23 (FGF-23)
P19883
Follistatin (FS)O00182
Galectin-9 (Gal-9)P27352
Gastric intrinsic factor (GIF)
P51161
Gastrotropin (GT)P01241
Growth hormone (GH)Q9UK05Growth/diﬀerentiation factor 2 (GDF-2)
P04792Heat shock 27 kDa protein (HSP 27)
P09601
Heme oxygenase 1 (HO-1)
Q9UJM8
Hydroxyacid oxidase 1 (HAOX1)
P18510Interleukin-1 receptor antagonist protein (IL-1ra)
Q9HB29Interleukin-1 receptor-like 2 (IL1RL2)
Q8TAD2
Interleukin-17D (IL-17D)
Q14116
Interleukin-18 (IL-18)
Q8NEV9, Q14213
Interleukin-27 (IL27)
P24394
Interleukin-4 receptor subunit alpha (IL-4RA)
P05231
Interleukin-6 (IL-6)
Q04760Lactoylglutathione lyase (GLO1)
P78380
Lectin-like oxidized LDL receptor 1 (LOX-1)
P41159
Leptin (LEP)
P06858
Lipoprotein lipase (LPL)
Low aﬃnity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) P31994
P47992Lymphotactin (XCL1)
Q9UEW3Macrophage receptor MARCO (MARCO)

Olink Target 96 CardiovascularⅢ
TargetAminopeptidase N (AP-N)
Azurocidin (AZU1)
Bleomycin hydrolase (BLM hydrolase)
C-C motif chemokine 15 (CCL15)
C-C motif chemokine 16 (CCL16)
C-C motif chemokine 24 (CCL24)
C-X-C motif chemokine 16 (CXCL16)
Cadherin-5 (CDH5)
Carboxypeptidase A1 (CPA1)
Carboxypeptidase B (CPB1)
Caspase-3 (CASP-3)
Cathepsin D (CTSD)
Cathepsin Z (CTSZ)
CD166 antigen (ALCAM)
Chitinase-3-like protein 1 (CHI3L1)
Chitotriosidase-1 (CHIT1)
Collagen alpha-1(I) chain (COL1A1)
Complement component C1q receptor (CD93)
Contactin-1 (CNTN1)
Cystatin-B (CSTB)
E-selectin (SELE)
Elaﬁn (PI3)
Ephrin type-B receptor 4 (EPHB4)
Epidermal growth factor receptor (EGFR)
Epithelial cell adhesion molecule (Ep-CAM)
Fatty acid-binding protein, adipocyte (FABP4)
Galectin-3 (Gal-3)
Galectin-4 (Gal-4)Granulins (GRN)
Growth/diﬀerentiation factor 15 (GDF-15)
Insulin-like growth factor-binding protein 1 (IGFBP-1)
Insulin-like Growth Factor-Binding Protein 2 (IGFBP-2)
Insulin-like growth factor-binding protein 7 (IGFBP-7)
Integrin beta-2 (ITGB2)Intercellular adhesion molecule 2 (ICAM-2)
Interleukin-1 receptor type 1 (IL-1RT1)
Interleukin-1 receptor type 2 (IL-1RT2)Interleukin-17 receptor A (IL-17RA)
Interleukin-18-binding protein (IL-18BP)
Interleukin-2 receptor subunit alpha (IL2-RA)
Interleukin-6 receptor subunit alpha (IL-6RA)
Junctional adhesion molecule A (JAM-A)
Kallikrein-6 (KLK6)
Low-density lipoprotein receptor (LDL receptor)
Lymphotoxin-beta receptor (LTBR)
Matrix extracellular phosphoglycoprotein (MEPE)

Uniprot No.
P15144
P20160
Q13867
Q16663
O15467O00175Q9H2A7
P33151
P15085
P15086
P42574
P07339Q9UBR2
Q13740
P36222
Q13231
P02452Q9NPY3
Q12860P04080P16581
P19957P54760
P00533
P16422
P15090P17931
P56470
P28799Q99988P08833
P18065
Q16270P05107
P13598P14778
P27930Q96F46
O95998
P01589P08887
Q9Y624
Q92876
P01130
P36941Q9NQ76

TargetMatrix metalloproteinase-12 (MMP-12)
Matrix metalloproteinase-7 (MMP-7)
Melusin (ITGB1BP2)
Natriuretic peptides B (BNP)
NF-kappa-B essential modulator (NEMO)
Osteoclast-associated immunoglobulin-like receptor (hOSCAR)
Pappalysin-1 (PAPPA)
Pentraxin-related protein PTX3 (PTX3)
Placenta growth factor (PlGF)
Platelet-derived growth factor subunit B (PDGF subunit B)
Poly [ADP-ribose] polymerase 1 (PARP-1)
Polymeric immunoglobulin receptor (PIgR)
Programmed cell death 1 ligand 2 (PD-L2)
Proheparin-binding EGF-like growth factor (HB-EGF)
Pro-interleukin-16 (IL16)
Prolargin (PRELP)
Prostasin (PRSS8)
Protein AMBP (AMBP)
Proteinase-activated receptor 1 (PAR-1)
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Proto-oncogene tyrosine-protein kinase Src (SRC)
P-selectin glycoprotein ligand 1 (PSGL-1)
Receptor for advanced glycosylation end products (RAGE)
Renin (REN)
Serine protease 27 (PRSS27)
Serine/threonine-protein kinase 4 (STK4)
Serpin A12 (SERPINA12)
SLAM family member 5 (CD84)
SLAM family member 7 (SLAMF7)
Sortilin (SORT1)
Spondin-2 (SPON2)
Stem cell factor (SCF)
Superoxide dismutase [Mn], mitochondrial (SOD2)
T-cell immunoglobulin mucin receptor 1 (TIM)
T-cell surface glycoprotein CD4 (CD4)
Thrombomodulin (TM)Thrombopoietin (THPO)
Thrombospondin-2 (THBS2)
Tissue factor (TF)
TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2)
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B)
Tyrosine-protein kinase Mer (MERTK)
Vascular endothelial growth factor D (VEGF-D)
V-set and immunoglobulin domain-containing protein 2 (VSIG2)

TargetMatrix metalloproteinase-2 (MMP-2)
Matrix metalloproteinase-3 (MMP-3)
Matrix metalloproteinase-9 (MMP-9)
Metalloproteinase inhibitor 4 (TIMP4)
Monocyte chemotactic protein 1 (MCP-1)
Myeloblastin (PRTN3)
Myeloperoxidase (MPO)
Myoglobin (MB)N-terminal prohormone brain natriuretic peptide (NT-pro BNP)
Neurogenic locus notch homolog protein 3 (Notch 3)
Osteopontin (OPN)
Osteoprotegerin (OPG)
P-selectin (SELP)
Paraoxonase (PON 3) (PON3)
Peptidoglycan recognition protein 1 (PGLYRP1)
Perlecan (PLC)
Plasminogen activator inhibitor 1 (PAI)
Platelet endothelial cell adhesion molecule (PECAM-1)
Platelet-derived growth factor subunit A (PDGF subunit A)
Platelet glycoprotein VI (GP6)
Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Protein delta homolog 1 (DLK-1)
Pulmonary surfactant-associated protein D (PSP-D)
Resistin (RETN)
Retinoic acid receptor responder protein 2 (RARRES2)
Scavenger receptor cysteine-rich type 1 protein M130 (CD163)
Secretoglobin family 3A member 2 (SCGB3A2)
Spondin-1 (SPON1)
ST2 protein (ST2)
Tartrate-resistant acid phosphatase type 5 (TR-AP)
Tissue factor pathway inhibitor (TFPI)
Tissue-type plasminogen activator (t-PA)
Transferrin receptor protein 1 (TR)Trefoil factor 3 (TFF3)
Trem-like transcript 2 protein (TLT-2)
Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)
Tumor necrosis factor receptor 1 (TNF-R1)
Tumor necrosis factor receptor 2 (TNF-R2)
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)
Tumor necrosis factor receptor superfamily member 6 (FAS)
Tyrosine-protein kinase receptor UFO (AXL)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS-1)
Urokinase plasminogen activator surface receptor (U-PAR)Urokinase-type plasminogen activator (uPA)von Willebrand factor (vWF)

Uniprot No.
P39900
P09237
Q9UKP3P16860
Q9Y6K9Q8IYS5
Q13219P26022
P49763P01127
P09874
P01833
Q9BQ51
Q99075
Q14005
P51888Q16651
P02760P25116
P21980
P12931
Q14242
Q15109P00797Q9BQR3
Q13043
Q8IW75Q9UIB8Q9NQ25
Q99523Q9BUD6
P21583
P04179
Q96D42
P01730P07204
P40225
P35442P13726O14763O00220
Q9Y6Q6
O14836
Q12866
O43915Q96IQ7

Uniprot No.
P08253
P08254
P14780Q99727
P13500P24158
P05164
P02144NA
Q9UM47
P10451O00300P16109Q15166
O75594
P98160P05121
P16284
P04085Q9HCN6Q8NBP7
P80370
P35247
Q9HD89Q99969Q86VB7
Q96PL1Q9HCB6
Q01638P13686
P10646
P00750P02786
Q07654
Q5T2D2
Q9Y275
P19438
P20333O14798
Q92956
P25445
P30530P78324
Q03405
P00749P04275◇ Oncology
癌の開始と進行の中心となる生物学的メカニズムに関与する 92 のタンパク質が分析対象となるパネルです。
ⅡとⅢの対象タンパク質は完全に異なっており、2 つのパネルで 184 種類のタンパク質がカバーできます。血管新生、細胞コミュニケーション、細胞代謝プロセス、アポトーシス、細胞増殖・分化等に関与するタンパク質です。Ⅲでは Cell surface A33 antigen, B-cell receptor CD22 などの癌関連バイオマーカーが対象となっています。

Olink Target 96 OncologyⅡ
TargetUniprot No.

P215895'-nucleotidase (5'-NT)
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) Q8TE58
P40222Alpha-taxilin (TXLNA)P15514
Amphiregulin (AR)P04083Annexin A1 (ANXA1)
Q16790Carbonic anhydrase 9 (CA9)P16870Carboxypeptidase E (CPE)
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) P13688
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) P06731
O60911Cathepsin L2 (CTSV)
O95971
CD160 antigen (CD160)
P26842
CD27 antigen (CD27)
P09326
CD48 antigen (CD48)
P32970CD70 antigen (CD70)
Q9UBG3Cornulin (CRNN)
Q9UJ71
C-type lectin domain family 4 member K (CD207)
O43927C-X-C motif chemokine 13 (CXCL13)
P38936
Cyclin-dependent kinase inhibitor 1 (CKN1A)
O00548
Delta-like protein 1 (DLL1)
Disintegrin and metalloproteinase domain-containing protein (ADAM8) P78325
Q9NQ30Endothelial cell-speciﬁc molecule 1 (ESM-1)
P29317Ephrin type-A receptor 2 (EPH2)
Q13158
FAS-associated death domain protein (FADD)
Q6BAA4
Fc receptor-like B (FCRLB)
Q14512
Fibroblast growth factor-binding protein 1 (FGF-BP1)
P15328
Folate receptor alpha (FR-alpha)P41439Folate receptor gamma (FR-gamma)
P09958Furin (FURIN)
P09382
Galectin-1 (Gal-1)
P35052Glypican-1 (GPC1)
P10144
Granzyme B (GZMB)
P20718Granzyme H (GZMH)
P14210Hepatocyte growth factor (HGF)
O75144ICOS ligand (ICOSLG)
P08069Insulin-like growth factor 1 receptor (IGF1R)
P06756Integrin alpha-V (ITGAV)P18084Integrin beta-5 (ITGB5)P15260Interferon gamma receptor 1 (IFN-gamma-R1)
P05231
Interleukin-6 (IL-6)
Q9UBX7
Kallikrein-11 (hK11)
Q9UKR3Kallikrein-13 (KLK13)
Q9P0G3Kallikrein-14 (hK14)
O60259Kallikrein-8 (hK8)
O95274
Ly6/PLAUR domain-containing protein 3 (LYPD3)Q16674
Melanoma-derived growth regulatory protein (MIA)
Q13421
Mesothelin (MSLN)

Olink Target 96 Oncology III
TargetUniprot No.

26S proteasome non-ATPase regulatory subunit 9
ADP-ribosylation factor-binding protein GGA1
Aldose reductase
Alkaline phosphatase, placental type
Allograft inﬂammatory factor 1
Alpha-actinin-4Alpha-fetoprotein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
B-cell receptor CD22
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Beta-hexosaminidase subunit alphaCadherin-related family member 2
Calcium-binding and coiled-coil domain-containing protein 1
CAP-Gly domain-containing linker protein 2
Caspase-2
Cell division cycle protein 27 homolog
Cell surface A33 antigen
Cerebellin-4
Choriogonadotropin subunit beta 3
CMRF35-like molecule 2
Collagen alpha-1(IX) chain
Complement C1q subcomponent subunit A
C-X-C motif chemokine 14
Cytosol aminopeptidase
Cytosolic 5'-nucleotidase 3A
dCTP pyrophosphatase 1
Developmentally-regulated GTP-binding protein 2
Elongin-A
Endoplasmic reticulum resident protein 44
Endoribonuclease LACTB2
FAD-linked sulfhydryl oxidase ALR
F-box-like/WD repeat-containing protein TBL1X
Forkhead box protein O3
General vesicular transport factor p115
Golgi-associated PDZ and coiled-coil motif-containing protein
Guanidinoacetate N-methyltransferase
Heat shock protein beta-6
Hemoglobin subunit theta-1
HLA class I histocompatibility antigen, alpha chain E
Immunoglobulin J chain
Inositol polyphosphate 1-phosphatase
Intercellular adhesion molecule 4Intercellular adhesion molecule 5Interferon gamma receptor 2Interleukin-1 beta
Interleukin-17F

O00233Q9UJY5
P15121
P05187
P55008
O43707
P02771
Q12904
P20273
Q9Y644
P06865Q9BYE9Q9P1Z2Q9UDT6
P42575
P30260Q99795Q9NTU7
P0DN86
Q496F6
P20849P02745
O95715
P28838Q9H0P0
Q9H773P55039Q14241
Q9BS26
Q53H82P55789O60907
O43524
O60763
Q9HD26
Q14353O14558P09105
P13747
P01591
P49441
Q14773
Q9UMF0
P38484
P01584
Q96PD4

TargetUniprot No.

P50579
Methionine aminopeptidase 2 (MetAP2)
Q29983, Q29980
MHC class I polypeptide-related sequence A/B (MIC-A/B)
P21741
Midkine (Mk)Q99717
Mothers against decapentaplegic homolog 5 (MAD homolog 5)
Q8WXI7
Mucin-16 (MUC-16)
Q96NY8Nectin-4 (PVRL4)
P01298
Pancreatic prohormone (PPY)O00592
Podocalyxin (PODXL)
P01133Pro-epidermal growth factor (EGF)
O00622
Protein CYR61 (CYR61)
P31949Protein S100-A11 (S100A11)
P26447
Protein S100-A4 (S100A4)
P07949Proto-oncogene tyrosine-protein kinase receptor Ret (RET)P04626
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
P21860Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Q15303
Receptor tyrosine-protein kinase erbB-4 (ERBB4)Q9BXY4R-spondin-3 (RSPO3)
O14828
Secretory carrier-associated membrane protein 3 (SCAMP3)Q9BYH1
Seizure 6-like protein (SEZ6L)
P09486SPARC (SPARC)
P21583
Stem cell factor (SCF)
P18827
Syndecan-1 (SYND1)
P56279T-cell leukemia / lymphoma protein 1A (TCL1A)
P37173
TGF-beta receptor type-2 (TGFR-2)
P48307
Tissue factor pathway inhibitor 2 (TFP1-2)
Q9HBG7
T-lymphocyte surface antigen Ly-9 (LY9)P50591
TNF-related apoptosis-inducing ligand (TRAIL)
O15455Toll-like receptor 3 (TLR3)
P01135
Transforming growth factor alpha (TGF-alpha)Q14956
Transmembrane glycoprotein NMB (GPNMB)
O75888Tumor necrosis factor ligand superfamily member 13 (TNFSF13)
P48023Tumor necrosis factor ligand superfamily member 6 (FASLG)
Q9NS68Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)
P43489Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)
O95407
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)
P00519Tyrosine-protein kinase ABL1 (ABL1)
P07948Tyrosine-protein kinase Lyn (LYN)
Q14508
WAP four-disulﬁde core domain protein 2 (WFDC2)
P15692
Vascular endothelial growth factor A (VEGF-A)
P35968
Vascular endothelial growth factor receptor 2 (VEGFR-2)
P35916
Vascular endothelial growth factor receptor 3 (VEGFR-3)
Q6UXB2
VEGF-co regulated chemokine 1 (CXL17)
P08670Vimentin (VIM)
Q9Y5W5Wnt inhibitory factor 1 (WIF-1)
O95388
WNT1-inducible-signaling pathway protein 1 (WISP-1)
O43895
Xaa-Pro aminopeptidase 2 (XPNPEP2)

TargetKallikrein-4
Lymphocyte-speciﬁc protein 1
MANSC domain-containing protein 1
N-acetylgalactosaminyltransferase 7
Neural cell adhesion molecule L1
Neuronal calcium sensor 1
Nicotinamide phosphoribosyltransferase
peroxisomal 3-ketoacyl-CoA thiolase
Persephin
Porphobilinogen deaminase
Probable serine carboxypeptidase CPVL
Promotilin
Pro-neuropeptide Y
Protein BRICK1
Protein canopy homolog 2
Protein kinase C-binding protein NELL1
Protein S100-A16
Protein tyrosine phosphatase type IVA 1
Protein XRP2
Protocadherin-1
Pulmonary surfactant-associated protein A1
Ras-related protein Rab-6A
Receptor-type tyrosine-protein kinase FLT3
Receptor-type tyrosine-protein phosphatase mu
Rho GTPase-activating protein 25
RNA-binding protein FUS
Secretagogin
Secretogranin-2
Selenocysteine lyase
Septin-9
Serine protease inhibitor Kazal-type 4
Synaptic vesicle membrane protein VAT-1 homolog
T-complex protein 1 subunit epsilon
Thiopurine S-methyltransferase
Thioredoxin domain-containing protein 15
Translationally-controlled tumor protein
Tumor necrosis factor alpha-induced protein 8
Ubiquitin-associated domain-containing protein 1
Unconventional myosin-IXb
Vacuolar protein sorting-associated protein 37A
Vacuolar protein sorting-associated protein 53 homolog
Vascular endothelial growth factor receptor 1
Vitelline membrane outer layer protein 1 homologvon Willebrand factor A domain-containing protein 1
V-type proton ATPase subunit D
YTH domain-containing family protein 3

Uniprot No.
Q9Y5K2
P33241Q9H8J5
Q86SF2
P32004
P62166
P43490P09110O60542
P08397Q9H3G5
P12872
P01303Q8WUW1Q9Y2B0Q92832Q96FQ6
Q93096
O75695
Q08174
Q8IWL2
P20340P36888P28827
P42331
P35637
O76038P13521
Q96I15Q9UHD8
O60575
Q99536
P48643
P51580
Q96J42
P13693
O95379Q9BSL1
Q13459Q8NEZ2
Q5VIR6
P17948
Q7Z5L0Q6PCB0
Q9Y5K8
Q7Z739Olink Target 96 Neurology

神経学的疾患（例えば、神経発達、軸索ガイダンス、シナプス機能、またはアルツハイマー病などの特定の状態）に関与するタンパク質が分析対象です。

TargetUniprot No.

P28907
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
P30533Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP)
Q16620
BDNF/NT-3 growth factors receptor (NTRK2)
P01138
Beta-nerve growth factor (Beta-NGF)
P12644
Bone morphogenetic protein 4 (BMP-4)
Q96GW7
Brevican core protein (BCAN)
Q2TAL6
Brorin (VWC2)
P22223
Cadherin-3 (CDH3)
P55285
Cadherin-6 (CDH6)
P48052
Carboxypeptidase A2 (CPA2)
P14384
Carboxypeptidase M (CPM)
P25774Cathepsin S (CTSS)
Q8N126
Cell adhesion molecule 3 (CADM3)
Q8TD46
Cell surface glycoprotein CD200 receptor 1 (CD200R1)
Q8TDQ1CMRF35-like molecule 1 (CLM-1)
Q08708
CMRF35-like molecule 6 (CLM-6)
O94779Contactin-5 (CNTN5)
Q9P126
C-type lectin domain family 1 member B (CLEC1B)
Q8IUN9C-type lectin domain family 10 member A (CLEC10A)
O95727
Cytotoxic and regulatory T-cell molecule (CRTAM)Q9UBT3
Dickkopf-related protein 4 (Dkk-4)
P53634
Dipeptidyl peptidase 1 (CTSC)
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) Q9P0K1
Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) O75077
Q8NBI3
Draxin (DRAXIN)
O15197Ephrin type-B receptor 6 (EPHB6)
P52798Ephrin-A4 (EFNA4)
Q08345Epithelial discoidin domain-containing receptor 1 (DDR1)
P15311Ezrin (EZR)
Q96LA5
Fc receptor-like protein 2 (FcRL2)
O00214
Galectin-8 (gal-8)
P56159GDNF family receptor alpha-1 (GFR-alpha-1)
O60609GDNF family receptor alpha-3 (GDNFR-alpha-3)
P39905Glial cell line-derived neurotrophic factor (GDNF)
P78333Glypican-5 (GCP5)
P09919Granulocyte Colony-Stimulating Factor (G-CSF)
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) P15509
P12544
Granzyme A (GZMA)O14793Growth/diﬀerentiation factor 8 (GDF-8)
Q16775
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)Interleukin-12 subunit beta, Interleukin-12 subunit alpha (IL-12B, IL-12A) P29460, P29459
Q01344
Interleukin-5 receptor subunit alpha (IL-5R-alpha)P57087
Junctional adhesion molecule B (JAM-B)
Q16719Kynureninase (KYNU)
Q9BS40Latexin (LXN)
Q6UX15
Layilin (LAYN)

Olink Target 96 Immuno-Oncology
TargetAdenosine deaminase
Adhesion G-protein coupled receptor G1
Angiopoietin-1
Angiopoietin-1 receptor
Angiopoietin-2
Arginase-1
Carbonic anhydrase 9Caspase-8
C-C motif chemokine 13
C-C motif chemokine 17
C-C motif chemokine 19
C-C motif chemokine 2
C-C motif chemokine 20
C-C motif chemokine 23
C-C motif chemokine 3
C-C motif chemokine 4
C-C motif chemokine 7
C-C motif chemokine 8
CD27 antigen
CD40 ligand
CD40L receptor
CD70 antigen
CD83 antigen
C-X-C motif chemokine 1
C-X-C motif chemokine 10
C-X-C motif chemokine 11
C-X-C motif chemokine 13
C-X-C motif chemokine 5
C-X-C motif chemokine 9
Cytotoxic and regulatory T-cell molecule
DecorinFas antigen ligand
Fibroblast growth factor 2
Fractalkine
Galectin-1
Galectin-9
Granzyme A
Granzyme B
Granzyme H
Heme oxygenase 1
Hepatocyte growth factor
ICOS ligand
Interferon gamma
Interleukin-1 alphaInterleukin-10
Interleukin-12

TargetUniprot No.

O43155
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)
Q6ISS4
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2)
O43561
Linker for activation of T-cells family member 1 (LAT)
Q14108
Lysosome membrane protein 2 (SCARB2)
P21757
Macrophage scavenger receptor types I and II (MSR1)
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) Q8NFP4P10636Microtubule-associated protein tau (MAPT)O15232Matrilin-3 (MATN3)
P55145
Mesencephalic astrocyte-derived neurotrophic factor (MANF)
Q02083N-acylethanolamine-hydrolyzing acid amidase (NAAA)
P08473
Neprilysin (NEP)
O95185
Netrin receptor UNC5C (UNC5C)
P41271
Neuroblastoma suppressor of tumorigenicity 1 (NBL1)
O14594
Neurocan core protein (NCAN)
Q92823
Neuronal cell adhesion molecule (Nr-CAM)
O60462
Neuropilin-2 (NRP2)
Q9NR71
Neutral ceramidase (N-Cdase)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Q9HAN9Q9BZM5
NKG2D ligand 2 (N2DL-2)
Q16288NT-3 growth factor receptor (NTRK3)
P41217
OX-2 membrane glycoprotein (CD200)
P16234
Platelet-derived growth factor receptor alpha (PDGF-R-alpha)O43157
Plexin-B1 (PLXNB1)Q9ULL4
Plexin-B3 (PLXNB3)P15151
Poliovirus receptor (PVR)
Q2VWP7
Protogenin (PRTG)
Q96B86
Repulsive guidance molecule A (RGMA)
Q6NW40
RGM domain family member B (RGMB)Q9HCK4
Roundabout homolog 2 (ROBO2)Q2MKA7
R-spondin-1 (RSPO1)Q6ZMJ2
Scavenger receptor class A member 5 (SCARA5)
Q96GP6
Scavenger receptor class F member 2 (SCARF2)
Q92765
Secreted frizzled-related protein 3 (sFRP-3)
P37023
Serine/threonine-protein kinase receptor R3 (SKR3)
Q9Y336
Sialic acid-binding Ig-like lectin 9 (Siglec-9)
Q9BZZ2
Sialoadhesin (SIGLEC1)Q9H3U7SPARC-related modular calcium-binding protein 2 (SMOC2)
P17405Sphingomyelin phosphodiesterase (SMPD1)
Q92752Tenascin-R (TN-R)
Q08629Testican-1 (SPOCK1)
P04216Thy-1 membrane glycoprotein (THY 1)
Q9H3S3
Transmembrane protease serine 5 (TMPRSS5)
Q9NP84
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
O75509Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)"Q9HAV5Tumor necrosis factor receptor superfamily member 27 (EDA2R)
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (WFIKKN1) Q96NZ8

免疫腫瘍学分野のバイオマーカー（腫瘍免疫の促進や阻害、走化性、血管や組織のリモデリング、アポトーシス等）
が分析対象です。
Uniprot No.

P00813
Q9Y653
Q15389Q02763O15123
P05089
Q16790Q14790Q99616
Q92583
Q99731
P13500P78556P55773
P10147
P13236
P80098P80075
P26842
P29965
P25942
P32970
Q01151
P09341
P02778O14625
O43927
P42830
Q07325
O95727
P07585
P48023
P09038P78423
P09382O00182
P12544
P10144P20718
P09601
P14210O75144
P01579P01583
P22301
P29459,P29460

TargetInterleukin-12 receptor subunit beta-1
Interleukin-13
Interleukin-15
Interleukin-18
Interleukin-2
Interleukin-33
Interleukin-4
Interleukin-5 (IL-5)
Interleukin-6
Interleukin-7
Interleukin-8
Killer cell iummunoglobulin-like receptor 3DL (KIR3DL1)
Latency-associated peptide transforming growth factor beta-1
Lymphocyte activation gene 3 protein (LAG-3)
Lysosome-associated membrane glycoprotein 3
Macrophage colony-stimulating factor 1
Macrophage metalloproteinase-12
Matrix metalloproteinase-7
MHC class I polypeptide-related sequence A/B
Mucin-16 (MUC-16)
Natural cytotoxicity triggering receptor
Natural killer cell receptor 2B4
Natural killer cells antigen CD94
Nitric oxide synthase, endothelial
Placenta growth factor
Platelet-derived growth factor subunit B
Pleiotrophin
Pro-epidermal growth factor
Programmed cell death 1 ligand 1
Programmed cell death 1 ligand 2
Programmed cell death protein 1
Stromal cell-derived factor 1
T-cell surface glycoprotein CD4
T-cell surface glycoprotein CD5
T-cell surface glycoprotein CD8 alpha chain
T-cell-speciﬁc surface glycoprotein CD28
TNF-related apoptosis-inducing ligand
Tumor necrosis factor
Tumor necrosis factor ligand superfamily member 12
Tumor necrosis factor ligand superfamily member 14
Tumor necrosis factor receptor superfamily member 12A
Tumor necrosis factor receptor superfamily member 21
Tumor necrosis factor receptor superfamily member 4Tumor necrosis factor receptor superfamily member 9
Vascular endothelial growth factor A
Vascular endothelial growth factor receptor 2

Uniprot No.

P42701
P35225
P40933
Q14116
P60568
O95760P05112P05113
P05231
P13232
P10145
P43629
P01137
P18627Q9UQV4
P09603
P39900
P09237
Q29983,Q29980
Q8WXI7
O76036Q9BZW8Q13241
P29474
P49763P01127
P21246
P01133Q9NZQ7Q9BQ51
Q15116
P48061
P01730P06127
P01732
P10747
P50591
P01375
O43508O43557
Q9NP84
O75509P43489Q07011
P15692
P35968Olink Target 96 Cardiometabolic 心代謝プロセス関連
TargetAngiogenin
Angiopoietin-related protein 3
Apolipoprotein M
Beta-Ala-His dipeptidase
Beta-galactoside alpha-2,6-sialyltransferase 1
C-C motif chemokine 14
C-C motif chemokine 18
C-C motif chemokine 5
Cadherin-1
Carbonic anhydrase 1
Carbonic anhydrase 3
Carbonic anhydrase 4
Cartilage acidic protein 1
Cartilage oligomeric matrix protein
CD59 glycoprotein
Coagulation factor VII
Coagulation factor XICollagen alpha-1(XVIII) chain
Complement C1q tumor necrosis factor-related protein 1
Complement C2
Complement factor H-related protein 5
Complement receptor type 2
Cystatin-C
Dipeptidyl peptidase 4
EGF-containing ﬁbulin-like extracellular matrix protein 1
Endoglin
Fetuin-B
Ficolin-2
Glutaminyl-peptide cyclotransferase
Granulysin
Growth arrest-speciﬁc protein 6
Hepatocyte growth factor receptor
Ig lambda-2 chain C regions
Insulin-like growth factor-binding protein 3
Insulin-like growth factor-binding protein 6
Integrin alpha-M
Intercellular adhesion molecule 1
Intercellular adhesion molecule 3Interleukin-7 receptor subunit alphaL-selectin
Latent-transforming growth factor beta-binding protein 2
Leukocyte immunoglobulin-like receptor subfamily B member 1
Leukocyte immunoglobulin-like receptor subfamily B member 2
Leukocyte immunoglobulin-like receptor subfamily B member 5
Lithostathine-1-alphaLiver carboxylesterase 1

Uniprot No.
P03950
Q9Y5C1
O95445Q96KN2
P15907
Q16627P55774
P13501
P12830
P00915
P07451
P22748Q9NQ79P49747P13987
P08709P03951
P39060Q9BXJ1
P06681Q9BXR6
P20023
P01034
P27487
Q12805
P17813
Q9UGM5
Q15485
Q16769P22749Q14393
P08581P0DOY2
P17936
P24592
P11215
P05362
P32942P16871
P14151
Q14767
Q8NHL6
Q8N423
O75023
P05451
P23141

TargetLow aﬃnity immunoglobulin gamma Fc region receptor II-a
Low aﬃnity immunoglobulin gamma Fc region receptor III-B
Lymphatic vessel endothelial hyaluronic acid receptor 1
Lysosomal Pro-X carboxypeptidase
Mannose-binding protein C
Mast/stem cell growth factor receptor Kit
Membrane cofactor protein
Membrane primary amine oxidase
Metalloproteinase inhibitor 1
Microﬁbrillar-associated protein 5
Multiple epidermal growth factor-like domains protein 9
Neural cell adhesion molecule 1
Neural cell adhesion molecule L1-like protein
Neurogenic locus notch homolog protein 1
Neuropilin-1
Neutrophil defensin 1
Neutrophil gelatinase-associated lipocalin
Nidogen-1
Oncostatin-M-speciﬁc receptor subunit beta
Peptidyl-glycine alpha-amidating monooxygenase
Phospholipid transfer protein
Plasma serine protease inhibitor
Platelet glycoprotein Ib alpha chain
Platelet-activating factor acetylhydrolase
Plexin-B2
Procollagen C-endopeptidase enhancer 1
Prolyl endopeptidase FAP
Receptor-type tyrosine-protein phosphatase S
Regenerating islet-derived protein 3-alpha
Serum amyloid A-4 protein
SPARC-like protein 1
Superoxide dismutase [Cu-Zn]
T-cell immunoglobulin and mucin domain-containing protein 4
Tenascin
Tenascin-X
Thrombospondin-4
Thyroxine-binding globulin
Transcobalamin-2
Transforming growth factor beta receptor type 3
Transforming growth factor-beta-induced protein ig-h3
Trypsin-2
Tyrosine-protein kinase receptor Tie-1
Uromodulin
Vascular cell adhesion protein 1
Vasorin
Vitamin K-dependent protein C

Uniprot No.
P12318O75015
Q9Y5Y7
P42785
P11226
P10721
P15529
Q16853
P01033
Q13361Q9H1U4
P13591
O00533
P46531O14786
P59665
P80188P14543
Q99650P19021P55058
P05154
P07359Q13093
O15031
Q15113
Q12884
Q13332
Q06141
P35542Q14515
P00441
Q96H15
P24821
P22105
P35443
P05543
P20062
Q03167
Q15582
P07478
P35590
P07911
P19320Q6EMK4
P04070Olink Target 96 Cell Regulation 細胞コミュニケーション、アポトーシスプロセス、細胞周期、細胞分化など
TargetUniprot No.

Q86SJ2
Amphoterin-induced protein 2
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Q7Z5R6
Q8TD06
Anterior gradient protein 3
P15848Arylsulfatase B
P08237
ATP-dependent 6-phosphofructokinase, muscle typeO43521-2
Bcl-2-like protein 11 isoform BimL
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Q02742
P21810
Biglycan
Q06520
Bile salt sulfotransferase
P11274
Breakpoint cluster region protein
Q9BWV1
Brother of CDO
Q9UBG0C-type mannose receptor 2
Q8N5S9Calcium/calmodulin-dependent protein kinase kinase 1
Q9BQT9Calsyntenin-3
Q9NX58Cell growth-regulating nucleolar protein
P04637
Cellular tumor antigen p53
Q49AH0
Cerebral dopamine neurotrophic factor
P02462
Collagen alpha-1(IV) chain
O43186
Cone-rod homeobox protein
P0CG37
Cryptic protein
Q8WYN0
Cysteine protease ATG4A
P16562
Cysteine-rich secretory protein 2
Q9UK85
Dickkopf-like protein 1
Q96PD2
Discoidin, CUB and LCCL domain-containing protein 2
P25685
DnaJ homolog subfamily B member 1
P52564
Dual speciﬁcity mitogen-activated protein kinase kinase 6
Q13561
Dynactin subunit 2
P22681E3 ubiquitin-protein ligase CBL
O75354Ectonucleoside triphosphate diphosphohydrolase 6
Q9NSA1
Fibroblast growth factor 21
Q01543
Friend leukemia integration 1 transcription factor
P47929Galectin-7
A4D1B5Gamma-secretase-activating protein
Q9NS71
Gastrokine
O00451GDNF family receptor alpha-2
P01275Glucagon
P01242Growth hormone variant
Q9Y662
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
O60243
Heparan-sulfate 6-O-sulfotransferase 1
O75054
Immunoglobulin superfamily member 3
Q9NRM6
Interleukin-17 receptor B
Q9UKR0Kallikrein-12
Q96I82
Kazal-type serine protease inhibitor domain-containing protein 1
Q6UXK5
Leucine-rich repeat neuronal protein 1
Q8N2G4
Ly6/PLAUR domain-containing protein 1
Q12912Lymphoid-restricted membrane protein

TargetMethionine aminopeptidase 1D, mitochondrial
Myelin-oligodendrocyte glycoprotein
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
NF-kappa-B inhibitor epsilon
NicalinNinjurin-1
Nuclear factor of activated T-cells, cytoplasmic 1
Oligodendrocyte-myelin glycoprotein
Opticin
Peroxiredoxin-6
Podocalyxin-like protein 2
Polypeptide N-acetylgalactosaminyltransferase 2
Probable carboxypeptidase X1Prokineticin-1
Prolactin regulatory element-binding protein
Protein FAM19A5
Protein Wnt-9a
Protocadherin-17
Ras GTPase-activating-like protein IQGAP2
Regulator of G-protein signaling 8
Rho GTPase-activating protein 1
Rho guanine nucleotide exchange factor 12
Seizure 6-like protein 2
Semaphorin-4C
Serine/threonine-protein kinase PAK 4
Sialic acid-binding Ig-like lectin 10
Sialic acid-binding Ig-like lectin 6
SLAM family member 8
SLIT and NTRK-like protein 2
SLIT and NTRK-like protein 6
Src kinase-associated phosphoprotein 1
Syntaxin-16
Syntaxin-6
T-cell leukemia/lymphoma protein 1B
Transcription factor AP-1
Transforming acidic coiled-coil-containing protein 3
Tudor and KH domain-containing protein
Tumor necrosis factor receptor superfamily member 10A
Tumor-associated calcium signal transducer 2
Vascular endothelial growth factor D
Vesicle-associated membrane protein 5
VPS10 domain-containing receptor SorCS2
Wiskott-Aldrich syndrome protein family member 1
Wiskott-Aldrich syndrome protein family member 3
Zinc ﬁnger and BTB domain-containing protein 16
Zinc ﬁnger and BTB domain-containing protein 17

Uniprot No.
Q6UB28Q16653
O94760O00221
Q969V3
Q92982
O95644P23515Q9UBM4
P30041Q9NZ53
Q10471
Q96SM3
P58294
Q9HCU5Q7Z5A7O14904O14917
Q13576
P57771
Q07960Q9NZN5Q6UXD5
Q9C0C4
O96013
Q96LC7
O43699Q9P0V8
Q9H156Q9H5Y7
Q86WV1O14662
O43752
O95988P05412
Q9Y6A5
Q9Y2W6
O00220
P09758
O43915
O95183
Q96PQ0Q92558Q9UPY6
Q05516
Q13105

Olink Target 96 Neuro Exploratory 神経関連疾患や、軸索の発達、神経新生、シナプス形成などのプロセスに関与するタンパク質が対象。
TargetUniprot No.

6-pyruvoyl tetrahydrobiopterin synthase
Adhesion G protein-coupled receptor B3
Alanyl-tRNA editing protein Aarsd1
Alpha-(1,6)-fucosyltransferase
Amiloride-sensitive amine oxidase [copper- containing]
Annexin A10
Asialoglycoprotein receptor 1
Beta-defensin 4A
Beta-klotho
Bis(5'-adenosyl)-triphosphatase
Bone marrow stromal antigen 2
C-C motif chemokine 27
Cadherin-15
Cadherin-17
Calcineurin subunit B type 1
Calcium-regulated heat-stable protein 1
Calsyntenin-1
Carcinoembryonic antigen-related cell adhesion molecule 3
Cardiotrophin-1
CD302 antigen
CD63 antigen
Centrin-2
Collagen type IV alpha-3-binding protein
Cysteine-rich protein 2
Death domain-containing protein
Desmoglein-3
Dipeptidase 1
Dipeptidase 2
Disintegrin and metalloproteinase domain- containing protein 15
Dual speciﬁcity protein phosphatase 3E3 ubiquitin-protein ligase RNF31
Endoplasmin
Endothelin-converting enzyme 1
Ephrin type-A receptor 10
Eukaryotic translation initiation factor 4B
Fibroblast growth factor receptor 2
Gamma-interferon-inducible lysosomal thiol reductase
Gamma-synuclein
Glutathione hydrolase 5 proenzyme
Glutathione S-transferase P
GlycodelinGroup 10 secretory phospholipase A2
Guanylate-binding protein 2
Heme oxygenase 2
Immunoglobulin alpha Fc receptor
Immunoglobulin superfamily containing leucine-rich repeat protein 2

Q03393
O60242
Q9BTE6Q9BYC5
P19801Q9UJ72
P07306O15263
Q86Z14
P49789Q10589Q9Y4X3P55291
Q12864
P63098
Q9Y2V2
O94985
P40198Q16619Q8IX05
P08962
P41208
Q9Y5P4
P52943P78560
P32926
P16444Q9H4A9Q13444
P51452Q96EP0
P14625
P42892Q5JZY3P23588
P21802P13284
O76070
P36269P09211
P09466
O15496
P32456
P30519P24071Q6UXK2

TargetInhibitor of growth protein 1
Inositol monophosphatase 1
Integrin-linked kinase-associated serine/ threonine phosphatase 2C
Interferon lambda-1
Interleukin-15
Interleukin-3 receptor subunit alphaInterleukin-32
KIF1-binding protein
Killer cell immunoglobulin-like receptor 2DL3
Kin of IRRE-like protein 2
Latent-transforming growth factor beta-binding protein 3
Leptin receptor
Mitotic spindle assembly checkpoint protein MAD1
Myeloid cell surface antigen CD33
N-alpha-acetyltransferase 10
NEDD4-like E3 ubiquitin-protein ligase
NEDD8-conjugating enzyme UBE2F
Neurexophilin-1
Neuroﬁlament light polypeptide
Nucleophosmin
Peptidyl-prolyl cis-trans isomerase FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP7
Phosphoethanolamine/phosphocholine phosphatase
Phosphomevalonate kinase
Phosphoribosyltransferase domain-containing protein 1
Prefoldin subunit 2
Pregnancy-speciﬁc beta-1-glycoprotein 1
Proepiregulin
Proline-rich AKT1 substrate 1
Proteasome activator complex subunit 1
Protein ABHD14B
Protein NDRG1
Ribokinase
Ribosomal protein S6 kinase beta-1
Secreted frizzled-related protein 1
Signal recognition particle 14 kDa protein
SPARC-related modular calcium-binding protein 1
Teratocarcinoma-derived growth factor 1
Transmembrane glycoprotein NMB
Tubulin polymerization-promoting protein family member 3
Tubulin-folding cofactor B
Tumor necrosis factor receptor superfamily member 13C
Tyrosine-protein phosphatase non-receptor type 1
V-set and transmembrane domain-containing protein 1
V-type proton ATPase subunit F
Zinc ﬁnger protein Helios

Uniprot No.
Q9UK53
P29218Q9H0C8Q8IU54
P40933
P26951
P24001Q96EK5
P43628Q6UWL6
Q9NS15
P48357
Q9Y6D9
P20138
P41227O00308Q969M7
P58417
P07196
P06748Q13451
Q9Y680Q8TCT1
Q15126Q9NRG1Q9UHV9P11464
O14944
Q96B36
Q06323
Q96IU4
Q92597
Q9H477
P23443
Q8N474
P37108Q9H4F8P13385
Q14956
Q9BW30Q99426Q96RJ3
P18031
Q6UX27
Q16864
Q9UKS7

Olink Target 96 Immune Response 適応免疫応答、ウイルスに対する防御応答、リンパ球の活性化、炎症応答、サイトカインを介した
Targetシグナル伝達経路などの重要な生物学的プロセスに関与するタンパク質が対象。
Uniprot No.

Q7Z6M3Allergin-1
P15514
Amphiregulin
P27540Aryl hydrocarbon receptor nuclear translocator (ARNT protein)
Q13490Baculoviral IAP repeat-containing protein 2
P16278
Beta-galactosidase
P78410
Butyrophilin subfamily 3 member A2
Q01151
CD83 antigen (hCD83)
Q9UHC6
Contactin-associated protein-like 2
Q15517
Corneodesmosin
P28845
Corticosteroid 11-beta-dehydrogenase isozyme 1
P78310Coxsackievirus and adenovirus receptor (CAR)
Q9UMR7
C-type lectin domain family 4 member A
Q8WTT0C-type lectin domain family 4 member C
Q8WXI8C-type lectin domain family 4 member D
Q6UXB4C-type lectin domain family 4 member G
Q6EIG7
C-type lectin domain family 6 member A
Q9BXN2C-type lectin domain family 7 member A
Q07065
Cytoskeleton-associated protein 4
Q13574
Diacylglycerol kinase zeta (DAG kinase zeta)
Q96PD2
Discoidin, CUB and LCCL domain-containing protein 2
O00273DNA fragmentation factor subunit alpha
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) Q9UN19
Q14203Dynactin subunit 1
P19474E3 ubiquitin-protein ligase TRIM21
Q9GZT9Egl nine homolog 1
P51671
Eotaxin
Q04637
Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1)
P63241
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1)
Q96P31
Fc receptor-like protein 3 (FcR-like protein 3)
Q6DN72
Fc receptor-like protein 6 (FcR-like protein 6)
P09038Fibroblast growth factor 2 (FGF-2)
Q96DB9FXYD domain-containing ion transport regulator 5
P14317
Hematopoietic lineage cell-speciﬁc protein
P50135Histamine N-methyltransferase (HMT)P52294
Importin subunit alpha-5
Q8N608Inactive dipeptidyl peptidase 10
O43736Integral membrane protein 2A
Q9UKX5Integrin alpha-11
P23229Integrin alpha-6
P18564Integrin beta-6
Q8IU57
Interferon lambda receptor 1 (IFN-lambda receptor 1)
Q00978Interferon regulatory factor 9 (IRF-9)
P51617
Interleukin-1 receptor-associated kinase 1 (IRAK-1)
Q9NWZ3
Interleukin-1 receptor-associated kinase 4 (IRAK-4)
P22301
Interleukin-10 (IL-10)
P42701
Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1)

TargetInterleukin-5 (IL-5)
Interleukin-6 (IL-6)
Islet cell autoantigen 1
Keratin, type I cytoskeletal 19
Leukocyte immunoglobulin-like receptor subfamily B member 4
Lymphocyte activation gene 3 protein (LAG-3)
Lymphocyte antigen 75 (Ly-75)
Lysosome-associated membrane glycoprotein 3 (LAMP-3)
Mannan-binding lectin serine protease 1
MerlinMethylated-DNA--protein-cysteine methyltransferase
Natural cytotoxicity triggering receptor 1
Natural killer cells antigen CD94
Neurabin-2
Neurotrophin-4 (NT-4)
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3)
Parathyroid hormone/parathyroid hormone-related peptide receptor
PC4 and SFRS1-interacting protein
Peroxiredoxin-1
Peroxiredoxin-5, mitochondrial
Phosphoinositide 3-kinase adapter protein 1
Plexin-A4
Polypeptide N-acetylgalactosaminyltransferase 3
Probable ATP-dependent RNA helicase DDX58
Protein FAM3B
Protein HEXIM1
Protein kinase C theta typeProtein sprouty homolog 2 (Spry-2)
Protein-arginine deiminase type-2
SH2 domain-containing protein 1A
SH2B adapter protein 3
Signaling threshold-regulating transmembrane adapter 1
SRSF protein kinase 2
Stanniocalcin-1 (STC-1)
Stromal cell-derived factor 1 (SDF-1)
T-cell-speciﬁc surface glycoprotein CD28
Thioredoxin-dependent peroxide reductase, mitochondrial
TNF receptor-associated factor 2
TRAF family member-associated NF-kappa-B activator
Transcription factor AP-1
Transcription regulator protein BACH1
Triggering receptor expressed on myeloid cells 1 (TREM-1)
Tripartite motif-containing protein 5
Tryptase alpha/beta-1 (Tryptase-1)
Tumor necrosis factor receptor superfamily member EDAR
Zinc ﬁnger and BTB domain-containing protein 16

Uniprot No.
P05113
P05231
Q05084
P08727Q8NHJ6
P18627
O60449Q9UQV4
P48740
P35240P16455
O76036
Q13241
Q96SB3
P34130Q12968Q03431
O75475
Q06830P30044Q6ZUJ8Q9HCM2
Q14435
O95786
P58499
O94992
Q04759O43597
Q9Y2J8
O60880Q9UQQ2
Q9Y3P8P78362
P52823
P48061
P10747
P30048Q12933
Q92844
P05412O14867
Q9NP99Q9C035
Q15661
Q9UNE0
Q05516

Olink Target 96 Development
Target細胞の移動や運動、細胞外マトリックスの組織化、神経新生などのプロセスに関与するタンパク質が対象。
Uniprot No.

Q10588
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Q9UKK9ADP-sugar pyrophosphatase
P16112Aggrecan core protein
P05067
Amyloid beta A4 protein
Q9BY76
Angiopoietin-related protein 4P15289Arylsulfatase A
P50895
Basal cell adhesion moleculeP15291
Beta-1,4-galactosyltransferase 1
O43505
Beta-1,4-glucuronyltransferase 1
P08236
Beta-glucuronidase
P08118
Beta-microseminoprotein
O00585C-C motif chemokine 21
Q9Y240C-type lectin domain family 11 member A
Q86T13C-type lectin domain family 14 member A
P00918Carbonic anhydrase 2
P23280Carbonic anhydrase 6
Q9UBX1Cathepsin F
P11717
Cation-independent mannose-6-phosphate receptor
Q6YHK3
CD109 antigen
Q8N6Q3
CD177 antigen
Q9NNX6
CD209 antigen
P48960CD97 antigen
Q8TCZ2
CD99 antigen-like protein 2
Q4KMG0Cell adhesion molecule-related/down-regulated by oncogenes
Q6UXG3
CMRF35-like molecule 9
O43405
Cochlin
Q5KU26
Collectin-12
Q8IWV2
Contactin-4
P24387
Corticotropin-releasing factor-binding protein
Q15828Cystatin-M
Q9NZV1
Cysteine-rich motor neuron 1 protein
Q6UXH1
Cysteine-rich with EGF-like domain protein 2
P47712
Cytosolic phospholipase A2
Q02487
Desmocollin-2
Q9UBP4
Dickkopf-related protein 3
Q14118Dystroglycan
Q07108
Early activation antigen CD69
Q13822Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Q96AP7
Endothelial cell-selective adhesion molecule
Q96RD9Fc receptor-like protein 5P30043
Flavin reductase
O95633
Follistatin-related protein 3
Galactoside 3(4)-L-fucosyltransferase, Alpha-(1,3)-fucosyltransferase 5 Q11128, P21217
P01215Glycoprotein hormones alpha chain
P55808Glycoprotein Xg
Q8TDQ0Hepatitis A virus cellular receptor 2

Olink Target 96 Metabolism
TargetTargetUniprot No.

P04233
HLA class II histocompatibility antigen gamma chain
Q6UXH9Inactive serine protease PAMR1
P55103
Inhibin beta C chain
P08648Integrin alpha-5
P05556Integrin beta-1
P78552
Interleukin-13 receptor subunit alpha-1
O43278
Kunitz-type protease inhibitor 1
O43291
Kunitz-type protease inhibitor 2
Q08431
Lactadherin
Q16363Laminin subunit alpha-4
Q14696LDLR chaperone MESD
Q99538Legumain
Q6GTX8
Leukocyte-associated immunoglobulin-like receptor 1
P06734
Low aﬃnity immunoglobulin epsilon Fc receptor
P19256
Lymphocyte function-associated antigen 3
P14174
Macrophage migration inhibitory factor
O00339Matrilin-2
Q99972Myocilin
Q14112
Nidogen-2
Q99983
Osteomodulin
Q9UKJ1
Paired immunoglobulin-like type 2 receptor alphaP23284
Peptidyl-prolyl cis-trans isomerase B
P30086
Phosphatidylethanolamine-binding protein 1
Q5VY43
Platelet endothelial aggregation receptor 1
P09619Platelet-derived growth factor receptor beta
Q99497
Protein deglycase DJ-1
P07237
Protein disulﬁde-isomerase
P48745
Protein NOV homolog
P10586
Receptor-type tyrosine-protein phosphatase F
Q9Y6N7
Roundabout homolog 1
Q14162
Scavenger receptor class F member 1
Q96QR1
Secretoglobin family 3A member 1
O75326
Semaphorin-7A
O43464
Serine protease HTRA2, mitochondrial
P00995
Serine protease inhibitor Kazal-type 1
Q9NQ38Serine protease inhibitor Kazal-type 5
O00241Signal-regulatory protein beta-1
P31948Stress-induced-phosphoprotein 1
O95721
Synaptosomal-associated protein 29
P63313Thymosin beta-10
P04066
Tissue alpha-L-fucosidase
O14773
Tripeptidyl-peptidase 1
Q969Z4
Tumor necrosis factor receptor superfamily member 19L
P29350Tyrosine-protein phosphatase non-receptor type 6
Q9Y279V-set and immunoglobulin domain-containing protein 4
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Q8TEU8細胞代謝、細胞表面受容体シグナル伝達、リン酸化、細胞接着などのプロセスに関与するタンパク質が対象。
Uniprot No.

P23526
Adenosylhomocysteinase (AdoHcyase)
Q9UHX3
Adhesion G protein-coupled receptor E2
Q8IZP9Adhesion G-protein coupled receptor G2
P51693Amyloid-like protein 1 (APLP)O15123
Angiopoietin-2 (ANG-2)
O95841
Angiopoietin-related protein 1
O43827
Angiopoietin-related protein 7
P50995Annexin A11
P09525Annexin A4
Q9UBU3
Appetite-regulating hormone
P05089Arginase-1
P20711
Aromatic-L-amino-acid decarboxylase (AADC)
P40259B-cell antigen receptor complex-associated protein beta chain
P19022Cadherin-2
Q9HBB8Cadherin-related family member 5
Q9H4D0Calsyntenin-2
Q8N1Q1
Carbonic anhydrase 13
P21964
Catechol O-methyltransferase
P43234Cathepsin O
Q9Y5K6CD2-associated protein
Q6WN34
Chordin-like protein 2
Q15846
Clusterin-like protein 1
Q76M96
Coiled-coil domain-containing protein 80
P46109Crk-like protein
Q9NY25C-type lectin domain family 5 member A
Q9H6B4CXADR-like membrane protein
Q9NR28
Diablo homolog, mitochondrial
P09417Dihydropteridine reductase
Q9UHL4
Dipeptidyl peptidase 2
P98082Disabled homolog 2
P27695DNA-(apurinic or apyrimidinic site) lyase
O75356Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) Q6UWV6P12724
Eosinophil cationic protein (ECP)
Q96LA6
Fc receptor-like protein 1 (FcR-like protein 1)
P09467
Fructose-1,6-bisphosphatase 1 (FBPase 1)
P22466
Galanin peptides
P09104Gamma-enolase
P35754Glutaredoxin-1
O75791
GRB2-related adapter protein 2
P51858Hepatoma-derived growth factor (HDGF)
Q01973Inactive tyrosine-protein kinase transmembrane receptor ROR1
Q8WX77
Insulin-like growth factor-binding protein-like 1
P26010Integrin beta-7
O43240Kallikrein-10
Q16773Kynurenine--oxoglutarate transaminase 1

TargetUniprot No.

P46379Large proline-rich protein BAG6
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Q96JA1
A6NI73
Leukocyte immunoglobulin-like receptor subfamily A member 5
Q86VZ4Low-density lipoprotein receptor-related protein 11 (LRP-11)
Q9NPH0
Lysophosphatidic acid phosphatase type 6
Q16820
Meprin A subunit beta
Q641Q3
Meteorin-like protein
Q8NI22Multiple coagulation factor deﬁciency protein 2
O95544NAD kinase
Q92692
Nectin-2
Q9NQX5
Neural proliferation diﬀerentiation and control protein 1 (NPDC-1)
O95502
Neuronal pentraxin receptor
Q15155
Nodal modulator 1NA
N-terminal prohormone of brain natriuretic peptide
Q9UKJ0
Paired immunoglobulin-like type 2 receptor beta
Q02790Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Q9NWQ8
P09668Pro-cathepsin H
Q92520Protein FAM3C
P41236
Protein phosphatase inhibitor 2 (IPP-2)
P25815
Protein S100-P
Q9BYZ8
Regenerating islet-derived protein 4 (REG-4)
Q9BZR6
Reticulon-4 receptor
P00352Retinal dehydrogenase 1 (RALDH 1)
P16083
Ribosyldihydronicotinamide dehydrogenase [quinone]
Q8WTU2
Scavenger receptor cysteine-rich domain-containing group B protein
Q9BQB4
Sclerostin
Q13275
Semaphorin-3F
P35237
Serpin B6
P50452
Serpin B8
Q9Y286
Sialic acid-binding Ig-like lectin 7 (Siglec-7)
Q04900Sialomucin core protein 24 (MUC-24)
Q8WVQ1
Soluble calcium-activated nucleotidase 1 (SCAN-1)
Q8NBJ7
Sulfatase-modifying factor 2
O00161
Synaptosomal-associated protein 23 (SNAP-23)
P31431
Syndecan-4 (SYND4)
P29017
T-cell surface glycoprotein CD1c
P52888Thimet oligopeptidase
Q8NBS9Thioredoxin domain-containing protein 5
P19971
Thymidine phosphorylase (TP)P01222Thyrotropin subunit beta
Q03403
Trefoil factor 2
Q9GZM7
Tubulointerstitial nephritis antigen-like
Q06418Tyrosine-protein kinase receptor TYRO3
P40818
Ubiquitin carboxyl-terminal hydrolase 8P13611
Versican core protein

Olink Target 96 Organ Damage
Targetストレス応答、細胞増殖調節、細胞周期、細胞死 / アポトーシスなどのプロセスに関与するタンパク質が対象。
Uniprot No.

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) Q9P0J1
Q9Y4785'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1)
Q9Y653
Adhesion G-protein coupled receptor G1
P30838
Aldehyde dehydrogenase, dimeric NADP-preferring
O95994
Anterior gradient protein 2 homolog (AG-2)
O95831Apoptosis-inducing factor 1, mitochondrial
Q8NDB2B-cell scaﬀold protein with ankyrin repeats
P55957BH3-interacting domain death agonist
Q13145
BMP and activin membrane-bound inhibitor homolog
Q8NC01
C-type lectin domain family 1 member A
P23582C-type natriuretic peptide
P01258
Calcitonin
P27797
Calreticulin
O43570Carbonic anhydrase 12
Q9ULX7
Carbonic anhydrase 14
P48730Casein kinase I isoform delta (CKI-delta)
Q9HAW4
Claspin (hClaspin)
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) Q11201
O00748
Cocaine esterase
Q02246
Contactin-2
P06850Corticoliberin
Q86SJ6
Desmoglein-4
P42658
Dipeptidyl aminopeptidase-like protein 6
Q02880
DNA topoisomerase 2-beta
Q9Y5L3Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2)
O75354Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6)
O43854
EGF-like repeat and discoidin I-like domain-containing protein 3
P98073Enteropeptidase
Q9UHF1
Epidermal growth factor-like protein 7 (EGF-like protein 7)
P01588Erythropoietin
Q0Z7S8Fatty acid-binding protein 9
Q12778
Forkhead box protein O1
Q9NQ88Fructose-2,6-bisphosphatase TIGAR
O60760
Hematopoietic prostaglandin D synthase (H-PGDS)
Q96D42
Hepatitis A virus cellular receptor 1 (HAVcr-1)
Q13308Inactive tyrosine-protein kinase 7
O14713Integrin beta-1-binding protein 1
Interferon-inducible double-stranded RNA-dependent protein kinase activator A O75569
P43629Killer cell immunoglobulin-like receptor 3DL1
P09960
Leukotriene A-4 hydrolase (LTA-4 hydrolase)
Q9GZY6
Linker for activation of T-cells family member 2
P01229Lutropin subunit beta (Lutropin beta chain)
Q7L5Y9Macrophage erythroblast attacher
P40121
Macrophage-capping protein
Q9Y5V3
Melanoma-associated antigen D1
P53582
Methionine aminopeptidase 1 (MAP 1)

TargetUniprot No.

Q03426
Mevalonate kinase (MK)Q9Y4K4
Mitogen-activated protein kinase kinase kinase kinase 5
Q15797
Mothers against decapentaplegic homolog 1 (MAD homolog 1)
Q9NXA8NAD-dependent protein deacylase sirtuin-5, mitochondrial
Q9Y5A7
NEDD8 ultimate buster 1
P19878
Neutrophil cytosol factor 2 (NCF-2)
O60934
NibrinP29474
Nitric oxide synthase, endothelial
P80303
Nucleobindin-2
P20472
Parvalbumin alphaP49023
Paxillin
P68106
Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B)
O60240
Perilipin-1
O15357
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
P49763-3
Placenta growth factor (PlGF)
Q9NRA1
Platelet-derived growth factor C (PDGF-C)
P21246
Pleiotrophin (PTN)
Q8IUK5
Plexin domain-containing protein 1
Q86SR1
Polypeptide N-acetylgalactosaminyltransferase 10
P35070Probetacellulin
Q15116
Programmed cell death protein 1 (Protein PD-1)
Q07954
Prolow-density lipoprotein receptor-related protein 1 (LRP-1)
P25786
Proteasome subunit alpha type-1
Q9BXJ7
Protein amnionless
Q8N8S7
Protein enabled homolog
P53539Protein fosB
Q96RT1
Protein LAP2
P61244
Protein max
O75688
Protein phosphatase 1B
P50749Ras association domain-containing protein 2
P20936
Ras GTPase-activating protein 1 (GAP)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) Q12913
O75787
Renin receptor
Q9UKL0REST corepressor 1
P49788Retinoic acid receptor responder protein 1
Q7LG56
Ribonucleoside-diphosphate reductase subunit M2 B
Q86WD7
Serpin A9
Q15165
Serum paraoxonase/arylesterase 2 (PON 2)
Q9UNK0Syntaxin-8
O00186
Syntaxin-binding protein 3
P19429Troponin I, cardiac muscle
P07332Tyrosine-protein kinase Fes/Fps
P09769Tyrosine-protein kinase FgrP07947
Tyrosine-protein kinase Yes
Q7L8A9
Vasohibin-1
P42768
Wiskott-Aldrich syndrome protein (WASp)

マウス用パネル
Olink Target 96 Mouse Exploratory
TargetUniprot No.

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (Apbb1ip )Appetite-regulating hormone (Ghrl )Aryl hydrocarbon receptor (Ahr )Axin-1 (Axin1 )C-C motif chemokine 2 (Ccl2 )C-C motif chemokine 20 (Ccl20 )C-C motif chemokine 3 (Ccl3 )C-C motif chemokine 5 (Ccl5 )C-X-C motif chemokine 9 (Cxcl9 )Cadherin-6 (Cdh6 )Calsyntenin-2 (Clstn2 )Carbonic anhydrase 13 (Ca13 )Carboxypeptidase E (Cpe )Caspase-3 (Casp3 )Contactin-1 (Cntn1 )Contactin-4 (Cntn4 )CXADR-like membrane protein (Clmp )Cysteine-rich motor neuron 1 protein (Crim1 )Cytosolic phospholipase A2 (Pla2g4a )Delta-like protein 1 (Dll1 )Dihydropteridine reductase (Qdpr )Disintegrin and metalloproteinase domain-containing protein 23 (Adam23 )Dual speciﬁcity mitogen-activated protein kinase kinase 6 (Map2k6 )Dynactin subunit 2 (Dctn2 )Epithelial cell adhesion molecule (Epcam )Erythropoietin (Epo )Follistatin (Fst )Follistatin-related protein 3 (Fstl3 )Forkhead box protein O1 (Foxo1 )Friend leukemia integration 1 transcription factor (Fli1 )Platelet-derived growth factor subunit B (Pdgfb )Plexin-A4 (Plxna4 )Poly [ADP-ribose] polymerase 1 (Parp1 )Protein CYR61 (Cyr61 )Protein delta homolog 1 (Dlk1 )Protein phosphatase inhibitor 2 (Ppp1r2 )Protein S100-A4 (S100a4 )Protransforming growth factor alpha (Tgfa )Receptor tyrosine-protein kinase erbB-4 (Erbb4 )Repulsive guidance molecule A (Rgma )Ribosomal oxygenase 2 (Riox2 )Seizure 6-like protein 2 (Sez6l2 )Serine/threonine-protein kinase PAK 4 (Pak4 )Serine/threonine-protein kinase receptor R3 (Acvrl1 )Soluble calcium-activated nucleotidase 1 (Cant1 )Synaptosomal-associated protein 29 (Snap29 )Q8R5A3Q9EQX0
P30561
O35625
P10148
O89093
P10855
P30882P18340
P97326
Q9ER65
Q9D6N1
Q00493
P70677P12960
Q69Z26
Q8R373
Q9JLL0P47713
Q61483Q8BVI4
Q9R1V7
P70236
Q99KJ8Q99JW5
P07321
P47931Q9EQC7Q9R1E0
P26323
P31240Q80UG2
P11103
P18406
Q09163
Q9DCL8P07091
P48030Q61527Q6PCX7
Q8CD15
Q4V9Z5Q8BTW9Q61288Q8VCF1Q9ERB0Target

本パネルで分析対象となっているタンパク質 92 種類の GO 情報に基づく分類

Biological Process
Angiogenesis
Apoptotic process
Cell adhesion
Cell diﬀerentiation
Cellular metabolic proces
Chemotaxis
Developmental process
Immune response
MAPK cascade
Neurogenesis
Regulation of gene expression
Response to stress
Signal transduction
Other GO terms

Subcellular Location

Cell membrane : 9
Cytoplasm : 16

Secreted : 11
Cytosol : 4

Intracellular, other : 15

Nucleus : 11

Membrane : 15

Uniprot No.

Gamma-enolase (Eno2 )GDNF family receptor alpha-1 (Gfra1 )Glial cell line-derived neurotrophic factor (Gdnf )Glucagon (Gcg )Granulocyte-macrophage colony-stimulating factor (Csf2 )Growth-regulated alpha protein (Cxcl1 )Hepatocyte growth factor (Hgf )Immunoglobulin superfamily member 3 (Igsf3 )Integrin beta-1-binding protein 2 (Itgb1bp2 )Integrin beta-6 (Itgb6 )Interleukin-1 alpha (Il1a )Interleukin-1 beta (Il1b )Interleukin-10 (Il10 )Interleukin-17A (Il17a )Interleukin-17F (Il17f )Interleukin-23 receptor (Il23r )Interleukin-5 (Il5 )Interleukin-6 (Il6 )Kit ligand (Kitlg )Legumain (Lgmn )Leucine-rich repeat transmembrane protein FLRT2 (Flrt2 )Lipoprotein lipase (Lpl )Matrilin-2 (Matn2 )Melanoma-derived growth regulatory protein (Mia )N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Ddah1 )NAD kinase (Nadk )Neurogenic locus notch homolog protein 3 (Notch3 )Neurotrophin-3 (Ntf3 )Perilipin-1 (Plin1 )Peroxiredoxin-5, mitochondrial (Prdx5 )Tenascin-R (Tnr )Transforming growth factor beta receptor type 3 (Tgfbr3 )Latency-associated peptide transforming growth factor beta-1 (Tgfb1 )Tripeptidyl-peptidase 1 (Tpp1 )Troponin I, cardiac muscle (Tnni3 )Tumor necrosis factor (Tnf )Tumor necrosis factor ligand superfamily member 12 (Tnfsf12 )Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b )Tumor necrosis factor receptor superfamily member 12A (Tnfrsf12a )Tumor necrosis factor receptor superfamily member 27 (Eda2r )Tumor necrosis factor receptor superfamily member 6 (Fas )Tyrosine-protein kinase Yes (Yes1 )V-set and immunoglobulin domain-containing protein 2 (Vsig2 )Vascular endothelial growth factor D (Vegfd )WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Wﬁkkn2 )WNT1-inducible-signaling pathway protein 1 (Wisp1 )P17183
P97785
P48540P55095
P01587
P12850Q08048Q6ZQA6
Q9R000
Q9Z0T9P01582
P10749
P18893
Q62386
Q7TNI7Q8K4B4
P04401
P08505
P20826
O89017Q8BLU0P11152
O08746
Q61865Q9CWS0P58058Q61982
P20181Q8CGN5
P99029Q8BYI9
O88393P04202
O89023
P48787
P06804
O54907
O08712
Q9CR75Q8BX35
P25446
Q04736
Q9Z109P97946Q7TQN3O54775

Olink Target 48 Cytokine 受託サービス
サイトカイン研究および炎症関連疾患の究極のソリューション。

一度の分析でサイトカイン シグナル伝達関連など、45 のタンパク質の絶対定量値が得られます。
■ 検量線に基づく標準濃度単位 (pg/mL) での絶対定量。
■ 炎症性疾患の研究や多くの疾患の根底にある ” 炎症プロセス ” 研究で関連性の高い 45 種 (※) を厳選。
■ 1 つのパネルにつき、最大 40 サンプルの測定が可能。
■ 血清・血漿・脳脊髄液、唾液など幅広いサンプル種に対応。
■ 必要なサンプル量は※血漿の場合 1uL

45 タンパク質のうち、35 は、Target 96 inﬂamation に含まれているものです。

血清・血漿（その他のサンプルについてはお問合せください）48 サンプル┗ 40 サンプル┗ 8 コントロール

×

48 アッセイ┗ 45 ターゲット┗ 3 QC 用

40 検体を同時測定し、45 の対象タンパク質についての『定量値 (pg/ml)』算出。

仕様▶ 必要サンプル量
血清・血漿 20uL 以上をご提供ください。

▶ 納期
分析サンプルをお受け取りした日から1.5〜2ヶ月程度▶ サービス内容

・サンプル前処理┗ 96ウェルフォーマットへの分注作業┗ サンプル ランダマイゼーション
・Olink Target 48 分析
・専用ソフトウェアでの一次解析

▶ 納品物

・報告書
・データ
（エクセルファイル形式）

▶価格
基本料金
分析単価

￥500,000（税別）／ パネル￥20,000（税別）／ 検体例）2群 × 各 n=15 の場合￥500,000 ＋ ￥20,000×30 = ￥1,100,000
・多検体の場合、割引適応あり
・弊社（国内拠点）での分析のため、サンプル輸送費は〜2,000円程度です。
一般の宅配【冷凍便・ドライアイス梱包】でお送りください。

・分析遂行の最小検体数は20検体以上とさせて頂いております。
20検体以上未満でご依頼の場合には、別のユーザー様案件とのパネルシェアをお待ち頂く、または、20検体分の費用をご負担いただく事をお願いたします。

★ 詳しくはこちらからお問合せください！

Olink Target 48 Cytokine

炎症性疾患の研究や、多くの疾患の根底にある炎症プロセスに関連のあるターゲットで構成されたパネル

Cytokines

TargetUniprot No.

Fms-related tyrosine kinase 3 ligand (FLT3LG)
Granulocyte colony-stimulating factor (CSF3)
Granulocyte-macrophage colony-stimulating factor (CSF2)
Interferon gamma (IFNG)Interleukin-1 beta (IL1B)
Interleukin-2 (IL2)Interleukin-4 (IL4)Interleukin-6 (IL6)Interleukin-7 (IL7)Interleukin-8 (CXCL8)Interleukin-10 (IL10)
Interleukin-13 (IL13)
Interleukin-15 (IL15)
Interleukin-17A (IL17A)
Interleukin-17C (IL17C)
Interleukin-17F (IL17F)
Interleukin-18 (IL18)
Interleukin-27 (IL27)
Interleukin-33 (IL33)
Lymphotoxin-alpha (LTA)
Macrophage colony-stimulating factor 1 (CSF1)
Oncostatin-M (OSM)
Tumor necrosis factor (TNF)
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Thymic stromal lymphopoietin (TSLP)
Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

P49771
P09919P04141
P01579P01584
P60568P05112
P05231
P13232
P10145
P22301
P35225
P40933
Q16552
Q9P0M4
Q96PD4
Q14116Q8NEV9,Q14213
O95760
P01374
P09603P13725
P01375
P50591
Q969D9O43508Chemokines
TargetUniprot No.
P13500
P10147
P13236
P80098P80075
Q99616
Q99731
Q07325
P02778O14625
P51671
P48061C-C motif chemokine 2 (CCL2)
C-C motif chemokine 3 (CCL3)
C-C motif chemokine 4 (CCL4)
C-C motif chemokine 7 (CCL7)
C-C motif chemokine 8 (CCL8)
C-C motif chemokine 13 (CCL13)
C-C motif chemokine 19 (CCL19)
C-X-C motif chemokine 9 (CXCL9)C-X-C motif chemokine 10 (CXCL10)
C-X-C motif chemokine 11 (CXCL11)
Eotaxin (CCL11)
Stromal cell-derived factor 1 (CXCL12)

Other

TargetHepatocyte growth factor (HGF)
Interstitial collagenase (MMP1)
Macrophage metalloelastase (MMP12)
Oxidized low-density lipoprotein receptor 1 (OLR1)
Pro-epidermal growth factor (EGF)
Protransforming growth factor alpha (TGFA)
Vascular endothelial growth factor A (VEGFA)

特異性の高いアッセイ
下記の図は、Olink Target 48 Cytokine の抗体が目的のターゲットタンパク質に特異的であることをテストした結果です。

45 個のターゲットタンパク質（リコンビナントタンパク質）に対し、すべての組み合わせでアッセイを実施しています。
対角線上に数値の上昇が見られますが、これは、それぞれがターゲットのみを特異性高く認識していることを示していま

Concentration(pg/ml)

す。なお、図中の Ag-pool は、ポジティブコントロールで、すべてのタンパク質が検出されるサンプルです。

Ag-pool

Assay

Assay

Uniprot No.
P14210
P03956
P39900
P78380
P01133
P01135
P15692

Olink® Target
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