January 28, 2013
SymBio Pharmaceuticals Limited
Fuminori Yoshida
Representative Director
President and Chief Executive Officer

SymBio Completes Phase II Trial ofAntiemetic Transdermal Patch (SyB D-0701) in RINVTOKYO, Japan, January 28, 2013 -- SymBio Pharmaceuticals Limited (JASDAQ: 4582) today
announced the completion of the Phase II clinical trial of its antiemetic transdermal patch (SyB D-0701)
for the treatment of radiation-induced nausea and vomiting (RINV).

SyB D-0701 is a sustained-release transdermal patch containing granisetron, a commercially available
5-HT3 antagonist designed to continuously deliver the active agent through the skin for over five days.
Radiation therapy, which is categorized into total body irradiation and conventional fractionation, iswidely used to treat cancer in combination with various anticancer agent(s) and surgery. Patients often
experience treatment related radiation-induced nausea and vomiting (RINV) that can last from a few
days to several weeks.
The Phase II trial was a randomized double-blind comparative study consisting of 189 patients who
received local radiation therapy. Two patch sizes, 40cm2 (high dose) and 25cm2 (low dose), were
examined to determine dose response of SyB D-0701 versus placebo to reduce RINV. Statisticallysignificant efficacy was not observed with either the 25cm2 or 40cm2 patch in the trial, however, with the
40cm2 patch, a higher control rate of RINV versus placebo was observed. Further development of SyB
D-0701, pending the results of additional in-depth analyses of Phase II trial results, is being considered.

[Please see the following for further information on Glossary and SymBio ][Contact]
Hiroki Maekawa
Board Director, Corporate Officer, Chief Financial Officer
Tel: +081(0)3 5472 1125

Note to Editors

Glossary
1

Local radiation therapy: high energy radiation that is focused on tumors to destroy cancer cells andsuppress cancer cell growth.

2

Randomized double-blind comparative study: an experimental trial in which neither the subjects ofthe experiment nor the persons administering the experiment know the critical aspects of theexperiment; a double-blind procedure is used to guard against both experimenter bias and placebo
effects.
3Placebo: any substance known not to have any pharmacological effect (produces no meaningfulchanges in an organism, either chemical or biological, etc.) that is made to appear like an active (‘real’)drug
4

Dose response: a response pattern over a range of drug doses. Doses lower than the thresholdproduce no response, while those in excess of the threshold exert no additional efficacy response.

About SymBio Pharmaceuticals Limited
SymBio Pharmaceuticals Ltd, established in March, 2005, by Fuminori Yoshida who previously served
concurrently as Corporate VP of Amgen Ltd. and founding President of Amgen Japan (currently TakedaBio), aspires to be a leading commercial stage specialty pharmaceutical company in Asia Pacificdedicated to addressing underserved medical needs with a main focus in the areas of oncology,
hematology and autoimmune disease. The company’s underlying corporate mission is “delivering hope
to patients in need.” SymBio’s lead drug candidate, TREAKISYM® (bendamustine hydrochloride), hasbeen successfully developed and launched in Japan for refractory/relapsed indolent non-Hodgkin’s
lymphoma (NHL) and mantle cell lymphoma. The company is also actively developing bendamustine inseveral Phase II trials in Japan: frontline indolent NHL, refractory/relapsed aggressive NHL (Phase IIcompleted), and refractory/relapsed multiple myeloma. The product has been launched in Hong Kong,Singapore, Korea and Taiwan. For additional information, please visit our homepage at
http://www.symbiopharma.com.