March 6, 2014
SymBio Pharmaceuticals Limited
Fuminori Yoshida
Representative Director
President and Chief Executive Officer

Notice Concerning the Partial Amendment to the Articles of Incorporationand Election of Directors

SymBio Pharmaceuticals Limited (“the Company”) announces that at a Board of Directors’ meeting
held today, it has decided to submit, for discussion at the 9th Ordinary General Meeting of Shareholders
that will be held on March 27, 2014 (“the Shareholders’ Meeting”), a proposal as to the “PartialAmendment to the Articles of Incorporation” and “Election of six (6) Directors.”

1. Partial amendment to the Articles of Incorporation(1) Reason for the amendment
We propose to reduce the term of the Company’s Directors from two (2) years to one (1) year, inorder to clarify management responsibilities of the Company’s Directors and to put in place amanagement structure that is better equipped to deal with rapid changes in the businessenvironment. At the same time, we propose to delete the detailed rule as to Directors’ terms ofoffice.
(2) Details of amendment
The details of proposed amendment are as follows:(Amended portions shown with underlines)
Current Articles of Incorporation

Proposed amendmentChapter 4 Directors and Board of Directors(The term of office of Directors)
Article 22
The terms of office of Directors shall expire at
the close of the Ordinary General Meeting ofShareholders held with respect to the lastbusiness year ending within two (2) years ofafter their appointment.

Chapter 4 Directors and Board of Directors(The term of office of Directors)
Article 22
The terms of office of Directors shall expire at
the close of the Ordinary General Meeting ofShareholders held with respect to the lastbusiness year ending within one (1) year ofafter their appointment.

2. The term of office of the Director who was (Delete)appointed to fill a vacancy or to be an addition
to the Board shall expire at the same time as
the incumbent Directors.

2. Election of six (6) Directors(1) Reason for election
Once “Partial amendment to the Article of Incorporation” is passed at the 9th Shareholders’Meeting held on March 27, 2014, six (6) Directors will reach the end of the term at the conclusionof this Shareholders’ Meeting. We therefore propose, conditional upon the aforementioned proposal
passing, the election of the following candidates.
(2) Election of DirectorsNameReappointment/NewFuminori Yoshida

Reappointment

Takako Ebata

Reappointment

Current title
Representative Director, President
and Chief Executive Officer
Outside Director

Lowell Sears

Reappointment

Outside Director

George Morstyn

Reappointment

Outside Director

Milton Grannatt

Reappointment

Outside Director

George Vandeman

New appointment－※ Takako Ebata, Lowell Sears, George Morstyn, Milton Grannatt and George Vandeman are theOutside Directors as defined in the Companies Act in Japan.

(3) The brief profile of the new candidate is as follows:
Name(Date of birth)

Career summary
June 1966
January 1982

George Vandeman(January 16, 1940)※July 1995

Join in Latham & Watkins LLP
Senior Partner (Public relations attorney),
Latham & Watkins LLP
Senior Vice President and General Counsel,
Amgen Inc. (U.S.)

July 2005

Principal, Vandeman & Company (current)

September 2005

Director (Outside) of the Company(resigned on June 2008)

April 2006

Director, Value Vision Media, Inc.

※ We request the election of George Vandeman as Outside Director so that he may giveindependent, objective advice regarding the management of the Company to the management,
based on his plentiful knowledge and experience in law, Japan-U.S. pharmaceutical industryand many other industries.

[Contact]
Investor Relations
Tel: +81(0)3 5472 1125