䝷䜲䝣䝃䜲䜶䞁䝇䞉䜾䝷䞁䝗䝏䝱䝺䞁䝆䛾⌧≧䛸௒ᚋ
ḟୡ௦⏕࿨య⤫ྜ䝅䝭䝳䝺䞊䝅䝵䞁◊✲㛤Ⓨ䜾䝹䞊䝥䚷ጲ㔝䚷㱟ኴ㑻

ศᏊ䝇䜿䞊䝹◊✲㛤Ⓨ䝏䞊䝮ᮌᑎ䚷ペ⣖⣽⬊䝇䜿䞊䝹◊✲㛤Ⓨ䝏䞊䝮ᶓ⏣㻌⚽ኵ

⮚ჾ඲㌟䝇䜿䞊䝹◊✲㛤Ⓨ䝏䞊䝮㧗ᮌ㻌࿘䝕䞊䝍ゎᯒ⼥ྜ◊✲㛤Ⓨ䝏䞊䝮ᐑ㔝㻌ᝅ⬻⚄⤒⣔◊✲㛤Ⓨ䝏䞊䝮▼஭䚷ಙ⏕࿨యᇶ┙䝋䝣䝖䜴䜵䜰㛤Ⓨ䞉㧗ᗘ໬䝏䞊䝮Ὀᆅ㻌┿ᘯே



1䛭䜒䛭䜒䛾ືᶵ⏕࿨⌧㇟䛿᭱䜒」㞧䛷㞴䛧䛔ၥ㢟」㞧䛷⨾䛧䛔᣺⯙䛔䜢♧䛩㉸ከయ⣔ከ㝵ᒙၥ㢟䝇䞊䝟䞊䝁䞁䝢䝳䞊䝍䜢౑䛳䛶䚸䛣䛾」㞧䛺⏕࿨⌧㇟䜢ゎᯒ
グ㏙䛩䜛⏕≀Ꮫ䛛䜙䚸ண

10-8
Micro

䛩䜛⏕≀Ꮫ䜈

10-5
Meso

10-3~-2

100
Macro

2

◊✲㛤Ⓨ䛾ᴫせ䛸㐩ᡂ┠ᶆ䚷ᇶ♏᪉⛬ᘧ䛻ᇶ䛵䛟ゎᯒⓗ䜰䝥䝻䞊䝏䛸䚸኱㔞䛾ᐇ㦂䝕䞊䝍䛛䜙ᮍ▱䛾ἲ๎䛻㏕䜛ᐇ㦂䝕䞊䝍䛛䜙ゎᯒ䜈䛾䜰䝥䝻䞊䝏䚸䛥䜙䛻䛿ከ㝵ᒙ䜢㐃⤖䛩䜛䜰䝥䝻䞊䝏䛻䜘䜚䚸␗䛺䜛䝇䜿䞊䝹䛾◊✲䛸ᐇ㦂䝕䞊䝍䜢⤫ྜⓗ䛛䛴᭷ᶵⓗ䛻⤖䜃䛴䛡䚸䝨䝍䝇䜿䞊䝹䛸䛔䛖᱆㐪䛔䛾ᛶ⬟䜢ᣢ䛴䝇䞊䝟䞊䝁䞁䝢䝳䞊䝍䛾ᛶ⬟䜢䝣䝹䛻Ⓨ᥹䛧䚸⏕య䛷㉳䛣䜛✀䚻䛾⌧㇟䜢⌮ゎ䛧་⒪䛻㈉⊩䛩䜛䛯䜑䛾䝋䝣䝖䜴䜵䜰䜢㛤Ⓨ䛩䜛䚹䝇䜿䞊䝹㛫㐃⤖䜰䝥䝻䞊䝏ゎᯒⓗ䜰䝥䝻䞊䝏
䜲䜸䞁䝏䝱
䝛䝹

ศᏊ䝇䜿䞊䝹⣽⬊䝇䜿䞊䝹⚄⤒⣽⬊䚷䚷ᒁᡤᅇ㊰ᐇ㦂䝕䞊䝍䛛䜙ゎᯒ䜈䛾䜰䝥䝻䞊䝏䝨䝍䝇䜿䞊䝹䞉䝅䝭䝳䝺䞊䝅䝵䞁䝷䜲䝣䝃䜲䜶䞁䝇
䛾᪂䛯䛺ᡭẁ䛾ᥦ౪䝕䞊䝍ゎᯒ⼥ྜ⮚ჾ඲㌟䝇䜿䞊䝹!⏕࿨⌧㇟䛾⤫ྜⓗ䛺⌮ゎ䠄䠙⏕࿨䝥䝻㻌䜾䝷䝮䛾
⌮ゎ䞉෌⌧䞉ண 䠅

TGCTCTTATCTTCCTCCCACAGCTCCTG
GCCCATCATGGCTGGTGTGGCTAATGC
CCGCTATTAAACTTAATAAAAAACATTT
ATTTTCATTGCAATATTTTACTGATATTATACAGGGGGCATGGTTTGACT……

!䝦䝹䝇䝃䜲䜶䞁
䝇䜈䛾㈉⊩䚸ඛ➃་⒪➼䛾ᢏ⾡ᇶ┙䛾ᵓ⠏䝅䝇䝔䝮䚷䚷
඲⬻⬻䞉⚄⤒⣔
ᇶ♏ཎ⌮䠄᪉⛬ᘧ䠅!v!t䝰䝕䝹䛻䜘䜛ᢳ㇟໬y=f(x)+g(x)exp(az)㺃㺃㺃

኱つᶍ䝕䞊䝍+ {( v " v 0 ) # $} v

in!ࠉࠉ !out

=

"$ #

p +

1
%v
Re

3

䛣䜜䜎䛷䛾㛤Ⓨ䛾ᴫせ• ⤒⦋– 2006ᖺ䠍䠌᭶䛛䜙㛤Ⓨ䜢㛤ጞ䚸䛣䛾᫬䚸ศᏊ䞉⣽⬊䞉⮚
ჾ඲㌟䞉䝕䞊䝍ゎᯒ⼥ྜ䛾䠐䝏䞊䝮䚹ᖺᗘෆ䛻㧗ᗘ໬䝏䞊䝮䜢㏣ຍ䛧䚸䝋䝣䝖㛤Ⓨ䜢ᨭ᥼– 2007ᖺ䠍䠌᭶䛾⬻⚄⤒⣔䝏䞊䝮䜢㏣ຍ
– 2011ᖺ䠐᭶䛛䜙ி䜢౑䛳䛯㛤Ⓨ䛜㛤ጞ• 䝬䝛䞊䝆䝯䞁䝖– 䝋䝣䝖䜴䜵䜰㛤Ⓨ䛾㐍ᤖ≧ἣ䜢ⓗ☜䛻ᢕᥱ䛧䚸ᨭ᥼– 䝋䝣䝖䜴䜵䜰䛻䝥䝷䜲䜸䝸䝔䜱䞊䜢タᐃ䚸㔜Ⅼ໬
4㻵㻿㻸㼕㻹䛾䜰䝥䝸㛤Ⓨ≧ἣ
Phase II < 8192

Phase I < 256

II-0

Phase III on K

II-2

II-1

1024nds 12288nds 82944nds

Platypus-MM/CG
Platypus-REIN
MARBLE
CafeMol
ProteinDF
Platypus-QM/MM-FE
Platypus-QM
Platypus-QM/MM
Platypus-CGM/MM
RICS
ZZ-EFSI
ZZ-DOSEZZ-HIFUZZ-LUNG
UTHeart
ParaHaplo
NGS analyzer
ExRAT
SiGN-BN
SiGN-L1
SiGN-SSM
SBiP
LiSDASMEGADOCK
NEST
CMDN
VSM
NeuroMorphoKit
IOSSIM
cppmd
VLSVL

Goal: > 1 Pata FLOPS⌧ᅾ27ᮏ୰24ᮏ䛜ி䛷ື䛟

0

1

2

3

4

5

6

7

cppmd, ZZ-EFSI, UT-Heart䛾୕䛴䛿䠏Peta FLOPS䜢㉸䛘䛯8㻡䛭䜜䛮䜜䛾ᡂᯝ䜰䝢䞊䝹᫬ᮇ

➨୍㉮⪅

➨஧㉮⪅

➨୕㉮⪅

⚄⤒⣔⤫ྜ䝅䝭䝳䝺䞊䝍ከ๣᤼ฟ䝖䝷䞁䝇䝫䞊䝍
cppmd䠄ศᏊືຊᏛ䠅MARBLE⣽⬊䛛䜙⮚ჾ䜈
Platypus
ProteinDFศᏊ䛛䜙⣽⬊䜈
CafeMol
CafeMol(䝠䝇䝖䞁DNA䠅 RICS:⫢⣽⬊
HIFU ZZ-DOSE㔜䜲䜸䞁⢏Ꮚ
UTHeartSiGN SSM L1GNE
ZZ-EFSILiSDAS
ParaHaplo
MEGADOCK୰㛗ᮇ┠ᶆ
CMDN:኱⬻⓶㉁ᒁᡤᅇ㊰䝰䝕䝹NEST(⚄⤒ᅇ㊰⥙䠅䝇䜿䞊䝹䜢㉺䛘䛯᏶ᡂᚋ䛩䛠䛻ᡂᯝ᏶ᡂᚋ䚸1ᖺ௨ෆ䛻⤫ྜⓗ⌮ゎ䛻ྥ䛡䜢䜰䝢䞊䝹
ᡂᯝ䜢䜰䝢䞊䝹䛯ྲྀ䜚⤌䜏

6᫖ᖺᗘ䛛䜙䛾኱䛝䛺ኚ໬•

ᖹᡂ23ᖺ4᭶䜘䜚䛂ி䛃䜢ヨ㦂฼⏝䚹㻌ẁ㝵ⓗ䛻฼⏝䜢ᣑ኱䛧䚸䝋䝣䝖䜴䜵䜰䜢䝏䝳䞊䝙䞁䜾䚹䠄䛂ி䛃ඹ⏝㛤ጞ๓䜎䛷䛜ᮏ䝥䝻䝆䜵䜽䝖䛷฼⏝䛷䛝䜛ᮇ㛫䠅•ᙜึィ⏬䛷䛿䚸ᖹᡂ䠎䠐ᖺ䠍䠍᭶ᮎ䜎䛷฼⏝ྍ⬟㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌㻌䚷䚷䚷䚷㻌䚷䛆䛂ி䛃᏶ᡂ䛛䜙⣙䠐䞄᭶㛫䛇•ඹ⏝㛤ጞ䜢ᖹᡂ24ᖺ䠕᭶ᮎ䛻ኚ᭦㻌䠄ᖹᡂ24ᖺ2᭶7᪥䚷➨8ᅇHPCIィ⏬᥎㐍ጤဨ఍)– ⾗㆟㝔Ỵ⟬⾜ᨻ┘どጤဨ఍䠄ᅜ఍∧஦ᴗ௙ศ䛡䛾ᙳ㡪䠅㻞㻜㻝㻝ᖺ㻠᭶㻞㻜㻝㻞ᖺ㻤᭶㻞㻜㻝㻝ᖺ㻝㻞᭶㻞㻜㻝㻞ᖺ㻠᭶䛆ᐇ㉁⣙䠎䞄᭶▷⦰䛇ఱ䛸䛛䛧䛶䝥䝻䝎䜽䝖䞉䝷䞁䛾ィ⟬᫬㛫☜ಖ䛜ᚲせ䟿㻞㻜㻝㻞ᖺ㻤᭶㻞㻜㻝㻞ᖺ㻝㻞᭶㻞㻜㻝㻟ᖺ㻠᭶

10Peta ඹ⏝㛤ጞᙜึィ⏬ᚎ䚻䛻฼⏝䛷䛝䜛䝜䞊䝗ᩘ䛜ቑຍ䜎䛸䜑䛸ᬑཬάືኚ᭦ᚋ7䛂ி䛃ヨ㦂฼⏝ィ⏬
2012ᖺ7᭶23᪥ ඹ⏝㛤ጞ
2012ᖺ9᭶ᮎ
12

90000
Number of Nodes

70000

Nodes

60000
50000
40000
30000

PFLOPsヨ㦂฼⏝ᮇ㛫䜎䛸䜑IV-1: 1/23-2/14
IV-2: 3/1-3/14
V-1: 4/9-4/27
V-2: 5/21-6/8
VI: 7/30-9/14䠄⅊Ⰽ䛿ఇṆᮇ㛫䠅

10

8

6

PFLOPS

80000

4

20000
2
10000
0

0

8

UTHeart㻞㻜㻝㻞ᖺ㻢᭶㻞㻜㻝㻞ᖺ㻡᭶㻞㻜㻝㻞ᖺ㻠᭶㻞㻜㻝㻞ᖺ㻟᭶㻞㻜㻝㻞ᖺ㻞᭶㻞㻜㻝㻞ᖺ㻞᭶㻞㻜㻝㻞ᖺ㻝᭶㻞㻜㻝㻝ᖺ㻝㻞᭶㻞㻜㻝㻝ᖺ㻝㻝᭶㻞㻜㻝㻝ᖺ㻝㻜᭶㻞㻜㻝㻝ᖺ㻥᭶㻞㻜㻝㻝ᖺ㻥᭶㻞㻜㻝㻝ᖺ㻤᭶㻞㻜㻝㻝ᖺ㻣᭶㻞㻜㻝㻝ᖺ㻢᭶㻞㻜㻝㻝ᖺ㻡᭶㻞㻜㻝㻝ᖺ㻡᭶㻞㻜㻝㻝ᖺ㻠᭶㻞㻜㻝㻝ᖺ㻟᭶㻞㻜㻝㻝ᖺ㻞᭶㻞㻜㻝㻝ᖺ㻝᭶㻞㻜㻝㻜ᖺ㻝㻞᭶㻞㻜㻝㻜ᖺ㻝㻞᭶㻞㻜㻝㻜ᖺ㻝㻝᭶㻞㻜㻝㻜ᖺ㻝㻜᭶㻞㻜㻝㻜ᖺ㻥᭶100

LiSDAS
10000

MEGADOCK
SiGN-BNNESTIOSSIM1000

No. of Cores୺䛺䜰䝥䝸䛸ி฼⏝䝜䞊䝗ᩘᣑ኱䜈䛾㏣㝶䛾䜘䛖䛩
1000000

Platypus-MM/
CG
Platypus-REIN
MARBLE
100000ZZ-EFSI

ZZ-HIFU

cppmd

9

1
cppmd

IOSSIM

NeuroMorphoKit

VSM

CMDN

NEST

MEGADOCKLiSDAS

SiGN-SSM

SiGN-L1

SiGN-BNExRATNGS analyzer

ParaHaplo

UTHeart

ZZ-HIFU

ZZ-DOSEZZ-EFSI

RICS

Platypus-QM/MM

Platypus-QM

Platypus-QM/MM-FE

ProteinDF

CafeMol

MARBLE

Platypus-REIN

Platypus-MM/CG

Nodes

඲䜰䝥䝸䛾ி䛷౑⏝䛧䛯᭱኱䝜䞊䝗ᩘ䈊㻞㻣ᮏ୰㻝㻟ᮏ䛜㻝㻜㻘㻜㻜㻜䝜䞊䝗௨ୖ䜢㐩ᡂ

100,000

10,000

1,000

100
2012ᖺ7᭶ᮎ

2012ᖺ4᭶ᮎ2012ᖺ1᭶ᮎ10㻝㻜ศᏊ䝇䜿䞊䝹ศᏊ䝇䜿䞊䝹䝏䞊䝮䠖ᴫせ•䝏䞊䝮඲య┠ᶆ– ศᏊ䝇䜿䞊䝹䝏䞊䝮䛷䛿䚸㔞Ꮚ໬Ꮫ(QM)䚸ྂ඾ຊᏛ(MM)䚸⢒ど໬䝰䝕䝹(CG)䛾
᪉ἲ䛸䛭䜜䜙䜢㐃ᡂ䛩䜛QM/MM䚸MM/CG䛾᪉ἲ䜢☜❧䛧䚸ඹ㏻䝍䞊䝀䝑䝖䛸䛧䛶㑅䜣䛰ከ๣᤼ฟ䝖䝷䞁䝇䝫䞊䝍䞊䛸⬡⫫㓟௦ㅰ㓝⣲䛾ᶵ⬟䜢ゎᯒ䛩䜛• ୺せ䛺ᡂᯝ
– ከ๣᤼ฟ䝖䝷䞁䝇䝫䞊䝍䠖CG䛷⸆๣䛾⤖ྜ䚸᤼ฟ䝯䜹䝙䝈䝮䚷䚷䜢᫂䜙䛛䛻䛧䛯䚹MM䛷䛿⸆๣䛾ྲྀ䜚㎸䜏ᶵᵓ䜢᫂䜙䛛䛻䛧䛯䚹– ⬡⫫㓟௦ㅰ㓝⣲䠖኱つᶍ䛺䝗䝯䜲䞁㐠ື䛻䜘䜚䝏䝱䝛䝸䞁䜾ᶵ䚷䚷ᵓ䛜䛒䜚ᚓ䜛䛣䛸䜢♧䛧䛯䚹ከ๣᤼ฟ䢀䢓䢙䡹䢊䢛䡬䡼䡬㻭㼏㼞㻮– MM/CG䛾᪂つἲ䜢☜❧䛧䚸䝍䞁䝟䜽㉁⣔䛷䛾⢭ᐦ䛺⮬⏤䜶䝛䚷
HACD
䚷䚷䝹䜼䞊ᆅᙧ䜢᫂䜙䛛䛻䛧䛯䚹• ௒ᚋ䛾ணᐃ
䚷䚷䚷ᡓ␎䝥䝻䜾䝷䝮䜈ᘬ䛝⥅䛜䜜䜛ㄢ㢟䛸୍⯡ㄢ㢟䛸䛧䛶᥇ᢥ
ECH䚷䚷䚷䛥䜜䛯ㄢ㢟䛷䚸䜋䜌௒ᚋ䛾◊✲䛾⥅⥆䛜ᢸಖ䛥䜜䛯䚹ᖺᗘᮎ
KACT
䚷䚷䚷䜎䛷䛻䚸ඹ㏻䝍䞊䝀䝑䝖䛻䛚䛡䜛䛥䜙䛺䜛ᡂᯝ䜢๰ฟ䛩䜛䚹⬡⫫㓟௦ㅰ㓝⣲11ศᏊ䝇䜿䞊䝹ከ๣᤼ฟ䝖䝷䞁䝇䝫䞊䝍䛾⸆๣᤼ฟ䛸ྲྀ㎸
⸆๣ྲྀ㎸/MM⸆๣⤖ྜ/CG⸆๣᤼ฟ/CG⸆๣᤼ฟ/MM

3D-RISM
12ศᏊ䝇䜿䞊䝹᪂つ䝅䝭䝳䝺䞊䝅䝵䞁ἲ䛻䜘䜛᪂䛯䛺▱ぢ
MM/CG

QM/MM

On-the-fly Stringἲ䜰䝕䝙䝹㓟䜻䝘䞊䝊䛾ᇶ㉁⤖ྜ䛻క䛖❧యᵓ㐀ኚ໬

MSESἲ
Sortase䛾ኳ↛ኚᡂ䝗䝯䜲䞁䛾ᵓ㐀ศᕸ

QM/MM-RWFE-SCFἲ
!-䜰䝭䝷䞊䝊䛾኱つᶍ㛗᫬㛫㐠ື䛸ඹᙺ䛧䛯㓝⣲཯ᛂ
13⣽⬊䝇䜿䞊䝹⣽⬊䝇䜿䞊䝹◊✲㛤Ⓨ䝏䞊䝮䠖ᴫせ•䝏䞊䝮඲య┠ᶆ– ⮚ჾ䚸⤌⧊ෆ䛷䛾⣽⬊ᶵ⬟䛾䛖䛱䚸≉䛻ᐇ㦂䛷ほ 䛥䜜䜛⫢⮚䛾௦ㅰᶵ⬟䜢୰ᚰ䛻䛭䛾෌⌧䜢┠ᣦ䛩䚹䚷– ⣽⬊ෆ䛾≀㉁䛾᫬✵㛫ኚ໬䛻ᑐᛂ䛩䜛䛯䜑䚸⣽⬊ෆ䜢ᚤ⣽䛺᱁Ꮚ䛻ษ䜚ศ䛡䠄䝪䜽䝉䝹䝰䝕䝹䠅䚸⣽⬊ෆᡂศ䛾⃰ᗘ䛺䛹䛾೫䜚䛸ኚ໬䜢෌⌧ྍ⬟䛸䛩䜛䚹– 䝏䞊䝮㛫㐃ᦠㄢ㢟䛸䛧䛶䚸ୖグᡭἲ䜢⮚ჾ඲㌟䝇䜿䞊䝹䛷䛾⾑ᑠᯈ௦ㅰ䚸䚷䚷䚷䚷⬻⚄⤒⣽⬊䝏䞊䝮䛸䛾⭷㟁఩ᶵ⬟䛾෌⌧䛻ᒎ㛤䛩䜛䚹•ಶู䝔䞊䝬䛷㝿❧䛳䛯䜒䛾䇵 ⫢⣽⬊௦ㅰ䝰䝕䝹䛾ᵓ⠏䛸ᶵ⬟ศᢸ䜢ゎ᫂䈄 ᐇ ᝟ሗ䞉ᩥ⊩᝟ሗ䜢ඖ䛻௦ㅰ䝛䝑䝖䝽䞊䜽䜢㛤Ⓨ䛧䚸⫢⣽⬊௦ㅰ䝅䝭䝳䝺䞊䝅䝵䞁䜢ᐇ⌧䛩䜛䛣䛸䛻䜘䜚䚸⫢⣽⬊䛾ᶵ⬟ศᢸ䛻䜘䜛ᜏᖖᛶ䜢෌⌧䇵 ⾑ᑠᯈάᛶ䛸⾑ὶ㐃ᡂ䝅䝭䝳䝺䞊䝅䝵䞁䜢㛤Ⓨ䇵 ⚄⤒⣽⬊⭷㟁఩䝅䝭䝳䝺䞊䝅䝵䞁䜢ᐇ⌧䇵 ⣽⬊䛾᫬✵㛫䝅䝭䝳䝺䞊䝍㻾㻵㻯㻿䛾㛤Ⓨ
14⣽⬊䝇䜿䞊䝹⫢⣽⬊䝅䝭䝳䝺䞊䝅䝵䞁୰ᚰ㟼⬦ᇦ%#'B41,&䛷Ⓨ⌧ඃ఩㛛⬦ᇦ%!'B41,&䛷Ⓨ⌧ඃ఩P!"!#$%⢾᪂⏕&'ἀἵἕἩኽӳỆ()!*+,%⢾᪂⏕&'ợỦཋឋʩ੭
-.!*+,%⢾᪂⏕&'#!/01%ᒀ⣲ᅇ㊰&'
23(#45/01%⬡⫫㓟6㓟໬&'7894:*+,%⬡⫫㓟6㓟໬&'/4;<9=4:>2%䝋䝹䝡䝖䞊䝹௦ㅰ&'
5+?(:@㍺㏦%5+?A3*:䝅䝱䝖䝹&'P($'%ゎ⢾⣔&'!$%ゎ⢾⣔&'
C>2%ゎ⢾⣔&'(:1/%䜾䝹䝍䝭䞁⏘⏕&'()!>2%䝨䞁䝖䞊䝹䝸䞁㓟ᅇ㊰&')!(D>2%䝨䞁䝖䞊䝇䝸䞁㓟ᅇ㊰&'#E7C%⬡⫫㓟ྜᡂ&'⫢⣽⬊䞉኱⭠⒴௦ㅰ䝅䝭䝳䝺䞊䝅䝵䞁䜢⏝䛔䛯௦ㅰ䝅䝇䝔䝮ᛂ⟅ண 䛸Imaging MS䛻䜘䜛ᐇドC㻯㼍㼚㼏㼑㼞㻌㼏㼑㼘㼘ᧉᏦ؏ɶ࣎᩺Ꮶ؏

㓝⣲άᛶ䛾zonation䛺䛹䛾䝕䞊䝍䚸䛚䜘䜃㐣ཤ䛾ᩥ⊩䝕䞊䝍䚸Imaging MS䛾ᐇ 䝕䞊䝍䛺䛹䜢ཧ↷䛧䛶zonal heterogeneity䜢෌⌧

P

㻳㻸㻯

㻳㻸㻯

㻴㻷
㻸㻭㻯

㻸㻭㻯

C

15

䛂ி䛃䛻䛶RICS䛻䜘䜛⫢⣽⬊ヲ⣽௦ㅰ䝰䝕䝹䛜ືస䟿
RICC䛻䛶ᑠ⤌⧊䛾᫬✵㛫䝭䝳䝺䞊䝅䝵䞁䛜ືసィ⟬䝸䝋䞊䝇➼䛛䜙䚸ᑠつᶍィ⟬䛻䛶⤖ᯝ䛜ᮃ䜑䜛ᑠ⤌⧊䠄」ᩘ⣽⬊+⾑ὶ䠅ゎᯒ䛻㞟୰䞉⫢⮚䛻䛚䛡䜛⣽⬊䛾ᶵ⬟ศᢸ䜢ゎᯒ䞉⾑ὶ䛸䛾㐃ᡂゎᯒ䛻䜘䜚䚸⫢⤌⧊䛻䛚䛡䜛⣽⬊ᶵ⬟䜢ゎᯒ䞉㌿⛣ᛶ⫢䛜䜣䠄኱⭠䛜䜣䛾⫢㌿⛣䠅䛻䛚䛡䜛⫢⮚ணഛ⬟䛾ண

䛸ᐇド

15

⣽⬊䝇䜿䞊䝹⮚ჾ/඲㌟䝇䜿䞊䝹䝏䞊䝮㛫㐃ᦠㄢ㢟⬻⚄⤒䝏䞊䝮⾑ᑠᯈ⣽⬊௦ㅰ
䠋άᛶ໬䝰䝕䝹⾑ᑠᯈ⣽⬊䛸
ὶయ䛾㐃ᡂィ⟬⭷㟁఩ᶵ⬟䛻Hodgkin-Huxley䜢ᐇ⿦⾑⟶ෆ䛾⾑ᑠᯈάᛶ໬⾑ὶ㐃ᡂ䡸䢌䡩䢖䡬䡸䡪䢙⚄⤒⣽⬊⭷㟁఩ᶵ⬟䝅䝭䝳䝺䞊䝅䝵䞁⮚ჾ඲㌟䝇䜿䞊䝹⮚ჾ඲㌟䝇䜿䞊䝹䝏䞊䝮䠖ᴫせ•䝏䞊䝮඲య┠ᶆ– ⣽⬊䝇䜿䞊䝹䠈ศᏊ䝇䜿䞊䝹䛾ຠᯝ䜢ྲྀ䜚ධ䜜䛯䝬䝹䝏䝇䜿䞊䝹⏕యຊᏛ䝅䝭䝳䝺䞊䝅䝵䞁䛻䜘䜚䠈⑓ែ䛾ண 䜔἞⒪䛾ᨭ᥼䜢ྍ⬟䛸䛩䜛䝋䝣䝖䜴䜵䜰䛾㛤Ⓨ䜢⾜䛖䠊• ಶู䝔䞊䝬䛷䛾୺❧䛳䛯ᡂᯝ– ᚰ⮚䝅䝭䝳䝺䞊䝍㻌UT-Heart䠖䚷䛂ி䛃䛷䛾ィ⟬䛻䜘䜚䚷䛂䝃䝹䝁䝯䜰䊽ᚰ➽⣽⬊䊽ᚰ⮚඲య䛃䛾䠏㝵ᒙ⤫ྜ䛻ୡ⏺䛷ึ䜑䛶ᡂຌ䠊– ὶయᵓ㐀㐃ᡂ㻌ZZ-EFSI, ⾑ᰦ䝅䝭䝳䝺䞊䝍㻌ZZ-Throm䠖㻌᪂䛧䛔ὶయᵓ㐀㐃ᡂᡭἲ䜢㛤Ⓨ䠊㻌䛂ி䛃䛷䛾ィ⟬䛻䜘䜚㻌ୡ⏺᭱㏿㻌4.5䝨䝍䝣䝻䝑䝥䜢㐩ᡂ䠊⾑ᰦ⑕䛾ึᮇ㐣⛬䛾䝬䝹䝏䝇䜿䞊䝹䝅䝭䝳䝺䞊䝅䝵䞁䜢ᐇ᪋䠊㉥⾑⌫䛾Ꮡᅾ䛜⾑ᑠᯈ䛾ቨ㠃⢓╔䜢ಁ㐍䛥䛫䜛䛣䛸䜢෌⌧䠊– ㉸㡢Ἴ἞⒪䝅䝭䝳䝺䞊䝍 ZZ-HIFU䠖㻌ᅜ⏘ึ䛾㉸㡢Ἴ἞⒪ჾ䛾㛤Ⓨ䛻ྥ䛡䛶䠈ங䛜䜣἞⒪ჾタィ䛾䝅䝭䝳䝺䞊䝅䝵䞁䜢㛤ጞ䠊• ௒ᚋ䛾ணᐃ
䚷䚷䚷䛂ி䛃䛷䛾ᮏ᱁ⓗィ⟬䛾ᐇ⾜䠊䠄ヲ⣽䛿ྛ䝇䝷䜲䝗䛻䛶ㄝ᫂䠅17䝬䝹䝏䝇䜿䞊䝹䞉䝬䝹䝏䝣䜱䝆䝑䜽䝇ᚰ⮚䝅䝭䝳䝺䞊䝍㻔㼁㼀㻙㻴㼑㼍㼞㼠㻕䝭䜽䝻䝺䝧䝹䛾␗ᖖ䛸ᚰ⑌ᝈ䛾㛵ಀ䜢ྜ⌮ⓗ䛻ゎ᫂䛧䚸་Ꮫ䞉་⒪䛻㈉⊩䛩䜛᪥ᮏ䛾⊂⮬ᢏ⾡⮚ჾ඲㌟䝇䜿䞊䝹• UT-Heart䛿᪤䛻⮫ᗋ◊✲䛻౑⏝୰• 䜾䝷䞁䝗䝏䝱䝺䞁䝆䛷㛤Ⓨ䛥䜜䛯䝋䝣䝖䛾䛖䛱䠈䚷䚷၏୍䠈䛂ி䛃฼⏝䛾ඃඛㄢ㢟•ி䛾඲䝅䝇䝔䝮䜢౑䛳䛯ィ⟬䜢ᐇ⾜୰᥋╔䝍䞁䝟䜽␗ᖖி䛷䛿䛂ẟ⣽⟶䜎䛷෌⌧䛧䛯ෙᚠ⎔䛃䛸䛂⣽⬊ෆ䛾௦ㅰᶵᵓ䛃䜢ᑟධ䛧⹫⾑ᛶᚰ⑌ᝈ䛺䛹ከᵝ䛺⑓Ẽ䜢෌⌧ྑ䛾ື⏬䛿RICC䜢౑䛳䛯ணഛⓗィ⟬䛷䚸ෙ≧ື⬦䠄ᕥᅇ᪕ᯞ䠅㛢ሰ䛻䜘䜚䚸ጞ䜑䛿㓟⣲䚸䜔䛜䛶ATP䛜Ḟஈ䛩䜛ᛴᛶᚰ➽᱾ሰ䛾䝅䝭䝳䝺䞊䝅䝵䞁䚹Ⰽ䛿཰⦰ຊ䜢⾲䛩ྍど໬䠖ᐩኈ㏻䠄ᰴ䠅ṇᖖ䛺ෙᚠ⎔䠖䚷኱ື⬦䛛䜙ධ䛳䛯⾑ᾮ䛿䠐ᢿ⛬䛷ẟ⣽⾑⟶ᗋ䛻⮳䜛㛢ሰ63୓䝁䜰䡔17᫬㛫䛾ィ⟬䛻ᡂຌ䚹
18

⮚ჾ඲㌟䝇䜿䞊䝹་⏝⏬ീ䝕䞊䝍䛻㐺䛧䛯ὶయᵓ㐀㐃ᡂᡭἲ㻔㼆㼆㻙㻱㻲㻿㻵㻕䛸䈊䝬䝹䝏䝇䜿䞊䝹⾑ᰦ䝅䝭䝳䝺䞊䝍㻔㼆㼆㻙㼀㼔㼞㼛㼙㻕••䛂ி䛃䛾䝣䝹䝜䞊䝗ィ⟬䛷䠈ᐇຠ㏿ᗘ㻌4.5䝨䝍䝣䝻䝑䝥䝇䜢㐩ᡂ䠄ୡ⏺᭱㏿䛾ὶయᵓ㐀㐃ᡭ
ἲZZ-EFSI䛾㛤Ⓨ䛻ᡂຌ䠅⾑ᑠᯈ⾲㠃䛾GP1䠾!ศᏊ䛸⾑⟶ቨୖ䛾䡒WFศᏊ䛾䝍䞁䝟䜽㉁㛫┦஫స⏝䛻≧ែ㑄⛣⌮ㄽ䜢㐺⏝䛧䛯䝰䝕䝹䛻䜘䜚䠈⾑ὶィ⟬䛸䛾㐃ᡂ䛻ᡂຌ䠊⾑ᰦ᥋╔䛾䜘䜚䝸䜰䝸䝇䝔䜱䝑䜽䛺ィ⟬䛜ྍ⬟䛸䛺䜚䠈㉥⾑⌫䛾Ꮡᅾ䛜⾑ᑠᯈ᥋╔䛻䛿㔜せ䛸䛩䜛ᐇ㦂ⓗ஦ᐇ䜢䝅䝭䝳䝺䞊䝅䝵䞁䛻䜘䜚ᐇド䠊ഷ૴ ‫ق‬৴ਢ৬ৡ৾‫ك‬५ॣ‫ش‬ঝ৑
ৼ൩੿৷Ligand-Receptor੥়
(Stochastic Process)䞉ᐇຠ㏿ᗘ㻌䠐䠊䠑䝨䝍䝣䝻䝑䝥䜢㐩ᡂ!!
䠄ୡ⏺᭱㏿䛾ὶయᵓ㐀㐃ᡂᡭἲ㛤Ⓨ䠅•≀㉁ᣑᩓ
•௦ㅰ཯ᛂ䞉άᛶ•ᙧែኚ໬ী৕৑ৼ൩੿৷
(ী৕৿ৡ৾)19⮚ჾ඲㌟䝇䜿䞊䝹㉸㡢Ἴ἞⒪䝅䝭䝳䝺䞊䝍㻌㻔㼆㼆㻙㻴㻵㻲㼁㻕ங⭢⑌ᝈ἞⒪⏝㻞㻡㻢㼏㼔䜰䝺䜲䝖䝷䞁䝇䝕䝳䞊䝃䛾㛤Ⓨᨭ᥼㻔ᅜ⏘ึ䛾㉸㡢Ἴ἞⒪䛾㛤Ⓨ䛻ྥ䛡䛶䠅TSBMI*䛻䛚䛡䜛ప౵くデ᩿἞⒪ᶵჾ䛾㛤Ⓨ䛸䛾ඹྠ• ㉸㡢Ἴ䛷デ䛺䛜䜙㉸㡢Ἴ䛷἞⒪䛩
䜛἞⒪ჾ䛾タィ䛻ྥ䛡䛯䝅䝭䝳䝺䞊䝅䝵䞁• ୰ኸ㒊䛻デ᩿䝥䝻䞊䝤⏝䝩䞊䝹䜢‽ഛ䛩䜛ᚲせ䛒䜚䠊• 䝏䝱䝛䝹ᩘ䠊㓄⨨䜢䝅䝭䝳䝺䞊䝅䝵䞁䛻䜘䜚᳨ウ

256ch, 2MHz, F=0.8
*䝅䝇䝔䝮⑌ᝈ⏕࿨⛉Ꮫ䛻䜘䜛ඛ➃་⒪ᢏ⾡㛤ⓎᣐⅬ↔Ⅼ఩⨨䛻䜘䜛㉸㡢Ἴ㡢ሙ䛾ኚ໬

x=0mm, y=0mm

x=5mm, y=0mm

x=0mm, y=2mm

x=5mm, y=2mm

x=0mm, y=5mm
20

䝕䞊䝍ゎᯒ⼥ྜ◊✲㛤Ⓨ䝏䞊䝮䠖ᴫせ•䝏䞊䝮඲య┠ᶆ– 䛂⫵䛜䜣䛸⸆䛃䜢ඹ㏻䛾䝔䞊䝬䛻䛧䛶䚸䝀䝜䝮䛸⑌ᝈ䛾㛫䛻䛒䜛䝅䝇䝔䝮䛸⸆๣ᛂ⟅䜢ゎᯒ䛩䜛䛣䛸䜢ྍ⬟䛻䛩䜛䝋䝣䝖䜴䜵䜰䜢䚸䝀䝜䝮䝕䞊䝍ゎᯒ䚸㑇ఏᏊ䝛䝑䝖䝽䞊䜽ゎᯒ䚸䝍䞁䝟䜽㉁䝛䝑䝖䝽䞊䜽ゎᯒ䚸ཬ䜃䝕䞊䝍ྠ໬䛻䜘䜛䝅䝭䝳䝺䞊䝅䝵䞁䛾ほⅬ䛛䜙㛤Ⓨ•ಶู䝔䞊䝬䛷㝿❧䛳䛯䜒䛾䇵 ኱つᶍ㑇ఏᏊ䝛䝑䝖䝽䞊䜽᥎ᐃ䝋䝣䝖䜴䜵䜰㻿㼕㻳㻺䛾
㛤Ⓨ䛸䛭䛾ᛂ⏝䈄䈄•㻸㻝ṇ๎໬ἲ䛻䜒䛸䛵䛟኱つᶍ㑇ఏᏊ䝛䝑䝖䝽䞊䜽ゎᯒ䛷䚸䛜䜣䛾ᾐ₶䜔䝀䝣䜱䝏䝙䝤䛺䛹䛾ᢠ䛜䜣๣⪏ᛶ䛾ཎᅉ䛸䛺䛳䛶䛔䜛ୖ⓶㛫ⴥ㌿᥮䛾㘽㑇ఏᏊ⩌䜢୍ᣲ䛻ᤊ䛘䜛䛣䛸䛻ᡂຌ䠄㻿㼕㻳㻺㻙㻸㻝䠅኱つᶍ㑇ఏᏊ䝛䝑䝖䝽䞊䜽ゎᯒ䛻䜘䜚䚸⫵⭢䛜䜣䛾ணᚋ䛾Ⰻ䞉୙Ⰻ䝇䜲䝑䝏䛸䛺䛳䛶䛔䜛䝃䝤䝛䝑䝖䝽䞊䜽䞉㑇ఏᏊ⩌䛾ྠᐃ䛸ணᚋண 䠄㻿㼕㻳㻺㻙㻮㻺㻘㻌㻿㼕㻳㻺㻙㻿㻿㻹䠅– ⏕࿨య䝅䝭䝳䝺䞊䝅䝵䞁䛾䛯䜑䛾䝕䞊䝍ྠ໬ᢏ⾡ཬ䜃䝋䝣䝖䜴䜵䜰LiSDAS䛾㛤Ⓨ䇵 䝍䞁䝟䜽㉁䝛䝑䝖䝽䞊䜽᥎ᐃ䝋䝣䝖㻹㻱㻳㻭㻰㻻㻯㻷䇵 㻿㻺㻼ゎᯒ䝋䝣䝖㻼㼍㼞㼍㻴㼍㼜㼘㼛௒ᚋ䛾ணᐃ– ᐇ㦂⣔䝥䝻䝆䜵䜽䝖䛸㐃ᦠ䛧䝋䝣䝖䜴䜵䜰䜢ᬑཬ⫵䛜䜣䛾ศᏊ䝛䝑䝖䝽䞊䜽䞉⸆๣ᛂ⟅䝛䝑䝖䝽䞊䜽䜢ゎᯒ䛧⫵䛜䜣䛾ศᏊ⑓ែ䜢ᥥฟ㑇ఏᏊ䝛䝑䝖䝽䞊䜽䝍䞁䝟䜽㉁䝛䝑䝖䝽䞊䜽䝀䝜䝮䝕䞊䝍
ゎᯒ䝕䞊䝍ྠ໬

㻟㻚㻡

㻟

㻞㻚㻡

㻞

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㻝

㻜㻚㻡

21

㻜

㻙㻜㻚㻡

㻙㻝
㻜㻚㻡
㻜㻝 㻞 㻠 㻢

㻥

㻝㻞

㻝㻡 㻝㻤

㻞㻝 㻞㻠

㻞㻣

㻟㻜 㻟㻟

㻠㻤

21

኱つᶍ㑇ఏᏊ䝛䝑䝖䝽䞊䜽ゎᯒ䛷୍ᣲ䛻ᤊ䛘䛯䈊ୖ⓶㛫ⴥ㌿᥮䠄㻱㻹㼀䠅䛾㘽㑇ఏᏊ⩌䠄㻿㼕㻳㻺㻙㻸㻝䛾ᛂ⏝䠅ධຊ䠖762 ಶ䛾䛜䜣⣽⬊ᰴ㑇ఏᏊⓎ⌧䝕䞊䝍䠄Epitheial/Mesenchymal䛾䝷䝧䝹௜䛝ᰴ䠅
13,508 transcripts=13,006㻌㼙㻾㻺㻭㻗502㻌㼙㼕㻾㻺㻭ฟຊ䠖13,508ಶ䛾㑇ఏᏊ䛛䜙䛺䜛㑇ఏᏊ䝛䝑䝖䝽䞊䜽762ಶ䚷䚷䚷䚷㻌EMT䛾ᗘྜ䛷㑇ఏᏊ䝛䝑䝖䝽䞊䜽䛾ᵓ㐀䛜䛹䛾䜘䛖䛻ኚ໬䛩䜛䛛䛜ᥥฟ䛥䜜䛯䚹

L1ṇ๎໬ἲ䛻ᇶ䛵䛟኱つᶍ㑇ఏᏊ䝛䝑䝖䝽䞊䜽᥎ᐃ䠄SiGN-L1䠅
䠄1024䝁䜰䜢౑䛳䛶⌮ㄽୖ䠏㐌㛫䚸ᐇ㝿䛿3䞄᭶䛾ィ⟬䠅
Mol Cell 7(6): 1267-78, 2001
Nat Cell Biol 10(5): 593-601, 2008
J Biol Chem 285(22):16854-63, 2010
Nat Cell Biol 10(5): 593-601, 2008
Cancer Res 70(5):2115-25, 2010
J Cell Sci 122(Pt 7): 1014-24, 2009•䝇䝟䝁䞁䛜EMTไᚚᅉᏊ䛸䛧䛶ண 䛧䛯䝖䝑䝥䠎䠐㑇ఏᏊ䛾䛖䛱䠍2㑇ఏᏊ䛜䛂ᙜ䛯䛳䛶䛔䛯䛃䚹ṧ䜚䠍2㑇ఏᏊ䛻䛴䛔䛶䛿
EMT䛻㛵䛩䜛┤᥋ⓗ䛺⤖ᯝ䛿↓䛧䚹•㧗ᶫ㝯䠄ྡ኱་䠅䛜KLF5䛾䝜䝑䜽䝎䜴䞁
䛷EMT䛜㉳䛣䜛䛣䛸䜢ᐇ㦂䛷ド᫂
(Shimamura et al. PLoS ONE 2011)•

GRHL2䛜EMTㄏᑟ䛩䜛䛣䛸䛜Ⓨ⾲䛥䜜
䜛(Cieply B et al. Cancer Res 72(9):2440-53, 2012)

Nat Cell Biol 10(5): 593-601, 2008

Cancer Res 72(9):2440-53, 2012

PLoS ONE 6(6): e20804, 2011
Cancer Res 69(7):2783-91, 2009
PNAS 104(9): 3432-7, 2007

Cancer Res 70(5):2115-25, 2010

Cancer Res 62(6): 1613-8, 2002

Oncogene 24(14):2375-85, 2005

Shimamura T, Imoto S, Shimada Y, Hosono Y, Niida A,
Nagasaki M, Yamaguchi R, Takahashi T, Miyano S.䚷
(2011) A Novel Network Profiling Analysis Reveals
System Changes in Epithelial-Mesenchymal
Transition. PLoS ONE 6(6): e20804. 22ᢠ䛜䜣๣䝀䝣䜱䝏䝙䝤ᛂ⟅㻱㻳㻲㻾䝟䝇䜴䜵䜲㑇ఏᏊ⩌䛾ྠᐃ䛻䜘䜛䈊㻿㼠㼍㼓㼑㻌㻵㻌䛾⫵⭢䛜䜣䛾ணᚋண 䛾ᡂຌ䠄㻿㼕㻳㻺㻙㻿㻿㻹㻕
Yamauchi M*, Yamaguchi R*, Nakata A*, Kohno T*, Nagasaki M, Shimamura T, Imoto S, Saito
A, Ueno K, Hatanaka Y, Yoshida R, Higuchi T, Nomura M, Beer DG, Yokota J, Miyano S, Gotoh
N. (2012) Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic
Genes of Stage I Lung Adenocarcinoma. PLoS ONE 7(9): e43923.
ᅜ❧䛜䜣◊✲䝉䞁䝍䞊䝕䞊䝍ணᚋ䠄⏕Ṛ䠅↓෌Ⓨ⏕Ꮡᮇ㛫The power of survival prediction for the NCI
validation data set, the Duke data set and
NCC-Tokyo data set using the 139 genes.

⡿ᅜNCI䝕䞊䝍⫵ୖ⓶⣽⬊䛻䝀䝣䜱䝏䝙䝤ᢞ
୚/㠀ᢞ୚䛷EGF䛷่⃭䛧䛯஦౛ิ19᫬Ⅼ㑇ఏᏊⓎ⌧䝕䞊䝍䜢ྲྀᚓ

SiGN-SSM ≧ែ✵㛫䝰䝕䝹᥎ᐃ䝋䝣䝖䛷䝅䝭䝳䝺䞊䝅䝵䞁䝰䝕䝹䜢᥎ᐃ

≧ែ✵㛫䝰䝕䝹䝅䝭䝳䝺䞊䝅䝵䞁䛻䜘䜚䛂ண 䛾እ䜜䜛㑇ఏᏊ䛃䠄⸆䛾ຠ䛔䛶䛔䜛㑇ఏᏊ䠅䜢ᢳฟ᳨ウ䚹䠍䠏䠕㑇ఏᏊ䜢㑅ᐃ(A) Kaplan-Meier plots of overall survival (OS) andrecurrence-free survival (RFS) estimates for thestage I NCC-Tokyo data set without BAC histology.
(B) (B) Kaplan-Meier plot OS estimates for stage I
patients in the NCC-Tokyo data set divided into
EGFR mutation (+) or (2) group.

䠍䠏䠕㑇ఏᏊ䜢౑䛳䛶ணᚋண䜢⾜䛖䛸䚸ண 䛜ᅔ㞴䛸䛥䜜䛶䛔䛯䝇䝔䞊䝆㻌I 䛾⫵⭢䛜䜣䛾ணᚋண 䛜䛂ᙜ䛯䜛䛃䛣䛸䛜」ᩘ䛾䝕䞊䝍䛷᳨ド䛥䜜䛯䚹⡿ᅜDuke኱䝕䞊䝍

23⬻⚄⤒⣔

⬻⚄⤒⣔◊✲㛤Ⓨ䝏䞊䝮䠖ᴫせ•••䝏䞊䝮඲య┠ᶆ– 䜋ங㢮どぬ⣔䠈↓⬨᳝ື≀Ⴅぬ⣔䛻䛚䛡䜛ධฟຊ㛵ಀ䜢෌⌧䛷䛝䜛䝋䝣䝖䜴䜵䜰䛸ඹ䛻䠈䛭䜜䜙䛾ᵓᡂせ⣲䛷䛒䜛ᒁᡤᅇ㊰䛚䜘䜃⚄⤒⣽⬊䛾ືែ䜢෌⌧䛷䛝䜛䝋䝣䝖䜴䜵䜰䜢సᡂ䛩䜛䠊ಶู䝔䞊䝬䛾ᡂᯝᴫせ– ⚄⤒⣽⬊䝅䝭䝳䝺䞊䝅䝵䞁䛿䠈ிୖ䛾10000୪ิ䛻䜘䜚⣽⬊㦵᱁ไᚚ䜢෌⌧ྍ⬟䛻䛩䜛䛸䛧䛯ᙜึィ⏬䜢㐩ᡂ䠈䝣䜱䝻䝫䝕䜱䜰ᙧᡂ䠈㍈⣴ㄏᑟ䛺䛹䛾䝅䝭䝳䝺䞊䝅䝵䞁䛻ᒎ㛤䠊– ᒁᡤᅇ㊰䝅䝭䝳䝺䞊䝅䝵䞁䛿䠈⣙5"108ಶ䛾⣽⬊䛛䜙䛺䜛ᅇ㊰䛾䝅䝭䝳䝺䞊䝅䝵䞁䛻ᡂຌ䠈䛣䜜䜢⏝䛔䛶どぬὀព䛾ᙳ㡪䜢ㄪ䜉䛯䠄ヲ⣽䛿ྛ䝇䝷䜲䝗䠅䠊– 䜋ங㢮どぬ⣔䝅䝭䝳䝺䞊䝅䝵䞁䛿䠈どぬධຊ⣔䛾ྛᒙ䝰䝕䝹䛻䛴䛔䛶ி䛾1000୪ิ௨ୖ䛻䜘䜚ᙜึィ⏬䜢㐩ᡂ䠈ฟຊ⣔䛿⌮◊RICCୖ䛾䝅䝭䝳䝺䞊䝍䛸䝻䝪䝑䝖䝦䝑䝗䜢᥋⥆䛩䜛䛣䛸䛷䠈䜽䝻䞊䝈䝗䝹䞊䝥䜸䞁䝷䜲䞁ไᚚ䠄ᙜึィ⏬䠅䜢㐩ᡂ䛧䛯䠊– ↓⬨᳝ື≀Ⴅぬ⣔䝅䝭䝳䝺䞊䝅䝵䞁䛿䠈ヲ⣽ᵓ㐀䜢᭷䛩䜛⣽⬊䛾䝅䝭䝳䝺䞊䝅䝵䞁䛻䛴䛔䛶ிୖ䛾196608䝁䜰୪ิ䜎䛷㐩ᡂ䠈ᐇ㦂䝕䞊䝍䛛䜙ᅇ㊰䝟䝷䝯䞊䝍䜢୪ิ᥈⣴䛩䜛䜰䝹䝂䝸䝈䝮䜢⤌䜏ྜ䜟䛫䜛䛣䛸䛷䠈Ⴅぬ⣔୰ᯡᅇ㊰䛾㧗⢭⣽䝅䝭䝳䝺䞊䝅䝵䞁䜢ᐇ⌧䛧䛯䠄ヲ⣽䛿ྛ䝇䝷䜲䝗䠅䠊௒ᚋ䛾ணᐃ– 䝋䝣䝖䜴䜵䜰䛸䛧䛶䛾ᛶ⬟䛿ᙜึィ⏬䜢㐩ᡂ䛧䛯䛾䛷䠈ᛂ⏝◊✲䛻ὀຊ䛩䜛䛸ඹ䛻䠈ᒁᡤᅇ㊰䝅䝭䝳䝺䞊䝅䝵䞁䛿ୡ⏺᭱኱䛾ᅇ㊰䝅䝭䝳䝺䞊䝅䝵䞁䜢┠ᣦ䛧䛯䛔䠊24⬻⚄⤒⣔ᒁᡤᅇ㊰䝅䝭䝳䝺䞊䝅䝵䞁
ὀពಙྕ
L2/3
L4
L5
L6

どぬධຊ

Wagatsuma et al.,Frontiers Comput
Neurosci (2011)•㻌㻌᪂䛧䛔䝕䞊䝍ᵓ㐀䛾ᑟධ䛻䜘䛳䛶䠈ி䛾24576䝜䞊䝗䠄196608䝁䜰䠅䜢⏝䛔䛶䠈⣙5"108ಶ䛾⚄⤒⣽⬊䛛䜙䛺䜛ᒁᡤᅇ㊰䝅䝭䝳䝺䞊䝅䝵䞁䜢㐩ᡂ䛧䛯䠊䠊• どぬ㔝2䜹䝷䝮䝰䝕䝹䛷䠈䝖䝑䝥䝎䜴䞁ಙྕ䛾ྛᒙ䜈䛾ᙳ㡪䛻䛴䛔䛶♧၀䛧䛯䠊
25⬻⚄⤒⣔

↓⬨᳝ື≀Ⴅぬ⣔䝅䝭䝳䝺䞊䝅䝵䞁ヲ⣽⚄⤒䝅䝭䝳䝺䞊䝅䝵䞁䛾㧗୪ิ໬๓㐠ື୰ᯡ⚄⤒ᅇ㊰䛾⤖ྜ᥎ᐃMorphology

Physiology⤖ྜྍ⬟ᛶ᥎ᐃ

ᖹᆒάືᗘ䛾⟬ฟ䝙䝳䞊䝷䝹䝛䝑䝖䝽䞊䜽䝰䝕䝹䛻䜘䜛⤖ྜ᥎ᐃ

᥎ᐃ䞉෌ᵓᡂ䛥䜜䛯ᛂ⟅౛࢘࢕࣮ࢡࢫࢣ࣮ࣜࣥࢢ඲య㏻ಙ㸦$OOJDWKHU㸧࣭㏻ಙ᫬㛫ࡢᛴ⃭࡞ቑ኱ࡀ㸯୓ࣀ࣮ࢻ௨ୖࡢ㡿ᇦ࡛ほࡉࢀࡓ

㏻ಙ䛾᭱㐺໬䜢⥅⥆ᐇ᪋୰26

Ⴅぬ⣔୰ᯡᅇ㊰䛾㧗⢭⣽䝅䝭䝳䝺䞊䝅䝵䞁䜈⏕࿨యᇶ┙䝋䝣䝖䞉㧗ᗘ໬⏕࿨యᇶ┙䝋䝣䝖䜴䜵䜰㛤Ⓨ䞉㧗ᗘ໬䝏䞊䝮䠖ᴫせ
•

•

•

•

•

䝏䞊䝮඲య┠ᶆ– 䝥䝻䝆䜵䜽䝖䛷㛤Ⓨ䛥䜜䛯䝋䝣䝖䜴䜵䜰䛾ி䝁䞁䝢䝳䞊䝍ୖ䛷䛾㧗ᛶ⬟໬ᨭ᥼– ᇶ┙䝋䝣䝖䜴䜵䜰㛤Ⓨ– ⏘ᴗᛂ⏝䛻ྥ䛡䛯ᇶ┙㛤Ⓨ䠄኱つᶍ௬᝿໬ྜ≀䝷䜲䝤䝷䝸䛾㛤Ⓨ䠅㧗୪ิศᏊືຊᏛィ⟬䝁䜰䝋䝣䝖䜴䜵䜰– ி䝁䞁䝢䝳䞊䝍ୖ䛷䛾㧗ᗘ໬䛾䝜䜴䝝䜴⵳✚䚸䜎䛯䝁䜰䝋䝣䝖䜴䜵䜰䛸䛧䛶䛾௚䝋䝣䝖䜴䜵䜰䛾㧗ᛶ⬟໬᥎㐍䛾䛯䜑䛻㛤Ⓨ௚䝋䝣䝖䜴䜵䜰㧗ᛶ⬟໬䜈䛾ᨭ᥼– ௚䜰䝥䝸䜿䞊䝅䝵䞁䛾㧗ᗘ໬ᨭ᥼– ᐩኈ㏻䠄ᰴ䠅䜈䛾❆ཱྀᶵ⬟ᇶ┙䝋䝣䝖䜴䜵䜰㛤Ⓨ– ྍど໬䞉䝭䝗䝹䜴䜵䜰– ィ⟬⛉Ꮫ◊✲ᶵᵓ䛻⛣⾜䠄ᑠ㔝T䠅኱つᶍ௬᝿໬ྜ≀䝷䜲䝤䝷䝸䠄ᮾ኱⯪ὠ◊䠅
27⏕࿨యᇶ┙䝋䝣䝖䞉㧗ᗘ໬ศᏊືຊᏛィ⟬䝁䜰䝋䝣䝖䜴䜵䜰ி䝁䞁䝢䝳䞊䝍䛾䝣䝹䝅䝇䝔䝮䜢⏝䛔䛶
3.8PFLOPS䛾ᐇຠᛶ⬟䜢ᐇ⌧•ຠ⋡ 38%•1.8൨ཎᏊ䚸䜹䝑䝖䜸䝣•䜹䞊䝛䝹ຠ⋡ ~ 50%•FMM䛷䛾ຠ⋡ ~ 10%28⏕࿨యᇶ┙䝋䝣䝖䞉㧗ᗘ໬㻵㻿㻸㼕㻹䝁䞊䝗䛾㧗ᗘ໬ᨭ᥼
ง୸ঀ‫ॻش‬ਯभ௓୎
$"!!!
$!!!!

ঀ‫ॻش‬ਯ

4++56

78(9*/2:#"!!!

;/2/9/+'<=))<1#!!!!

;'/:3+&>"!!!
㼆㼆㻙㻱㻲㻿㻵
㻼㼘㼍㼠㼥㼜㼡㼟

!
%&'(##)*+(##??(9<@7??(A@)<,A)8㻼㼍㼞㼍㻴㼍㼜㼘㼛,-.(##%/0(#$

1/2(#$

1/3(#$

㼏㼜㼜㼙㼐%&'(#$

29⏕࿨యᇶ┙䝋䝣䝖䞉㧗ᗘ໬㻵㻿㻸㼕㻹䝁䞊䝗䛾㧗ᗘ໬ᨭ᥼
⛣᳜

ศᏊ

䕿
ᐩኈ㏻䝁䞁䝟䜲䝷ᑐᛂ(Cafemol)༢య䝏䝳䞊䝙䞁䜾

୪ิ
䝏䝳䞊䝙
䞁䜾

䛭䛾௚

䕿
SIMD, Pipeline (Cafemol)

⣽⬊
⮚ჾ඲㌟

䕿
Vsphere(ZZ-EFSI)䕿⬻䝡䝹䝗᪉ἲ䛾ᵓ⠏(IOSSIM)ᐩኈ㏻䝁䞁䝟䜲䝷ᑐᛂ䠄NEST)䝕䞊䝍ゎᯒ⼥
ྜ
㧗ᗘ໬

䕿

䕿

䕿

䕿

thread໬㻌(NEST)SIMD໬䠄IOSSIM)䝯䝰䝸ᾘ㈝๐ῶ㻌(NEST)䕿䕿ศᩓI/O (Parahaplo) ,FFT (MegaDock)

SIMD, Pipeline (LiSDAS)

䕿

䕿

䕿
30

䜎䛸䜑
•

•

•

㛤Ⓨ䛿ᙜึィ⏬㏻䜚䛷䚸㡰ㄪ– ி䛾1/8௨ୖ䜢౑䛳䛶䜒ᛶ⬟䛜ⴠ䛱䛺䛔䝋䝣䝖䜢䠍䠎ᮏ䠄඲య䛾⣙1/3䠅㛤Ⓨ– ி䛾䝋䝣䝖䛸䛧䛶᭱㧗䛾ᐇຠᛶ⬟䜢ฟ䛧䛯ZZ-EFSI䜢ึ䜑䚸cppmd䚸UT-Heart䚸ZZHIFU䛷㧗䛔ᐇ⾜ຠ⋡䜢㐩ᡂ䛯䛰䛧䚸ி䛾౪⏝㛤ጞ๓ಽ䛧䛷– ி䛾฼⏝䛜䠎䞄᭶▷⦰䠄ி඲య䛜౑䛘䜛ᮇ㛫䛜䠐䛛᭶䛛䜙䠎䞄᭶䛻༙ῶ䠅– 䛣䛾ᙳ㡪䛷ᙜึணᐃ䛧䛶䛔䛯ி䛾䝣䝹䝅䝇䝔䝮䜢౑䛳䛯ィ⟬䛿䚸ᐇ㉁UT-Heart䛰䛡ி䛷䛾ィ⟬䛾⤖ᯝ䛿ᚎ䚻䛻䜎䛸䜎䜚䛴䛴䛒䜚䚸ᡂᯝ䛜ฟ䛶䛝䛶䛔䜛31