╙ 9 ࿁ੱ㑆ᖱႎቇળ㩷 䊘䉴䉺䊷⊒⴫੍Ⓜ㓸㩷 ⋡ᰴ㩷㩷㩷䋱䋮䇸ᜰው┵⣂ᵄ⸃ᨆ䈮䉋䉍ផቯ䈘䉏䉎䊡䊷䉱䈱⁁ᘒ䈮ㆡᔕേ૞䈜䉎䉸䊐䊃䉡䉢䉝᭴▽䈱⹜䉂䇹㩷ᣂ੗㛁䇮የᐔ๺ਭ䇮ᚭㄝ⟵ੱ䇮㓶ጊ⌀ᑿ䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P1㩷㩷䋲䋮䇸Ꮢⴝ࿾䈮䈍䈔䉎Ꮕಽ䉴䊁䊧䉥䉕↪䈇䈢ੱᵹ⸘᷹ታ㛎䇹㩷ᩊ↰㓷⡡䇮᦭ᳯ⺈䇮↢ᒻᔀ䇮䊝䊨䊶䉝䊧䉾䉰䊮䊄䊨䇮⷏ᧄ㦖ᒄ䇮ኹᨋ⾫ม䇮㩷ᚭㄝ⟵ੱ䇮᪢↰๺᣹䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P5
㩷䋳䋮䇸๭ๆ䉶䊮䉲䊮䉫䈱↢ℂቇ⊛ᗧ⟵䈫䈠䈱ᣣᏱᔕ↪䇹㩷ᣉ⤪䇮Ꮉේ㕏ᒄ䇮᩿␽㓷䇮⟜ᔒஉ䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P7㩷

㩷䋴䋮䇸ᖱႎㅢାᛛⴚ䉕↪䈇䈢㖸ᭉ≮ᴺ䋨ᄢ㊂䈱ᣉⴚᖱႎ䈮䉋䉎ലᨐ⹏ଔ䈫㖸ᭉ≮ᴺ䊂䊷䉺䊶㩷䊙䉟䊆䊮䉫䇹㩷
ዊ᧖ዏሶ䇮ᢙ੗⵨శ䇮ㄭ⮮⌀↱䇮↰ㇱ੗⾫৻䇮⇌㓷ਯ䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P9㩷㩷䋵䋮䇸㓐઻ᕈ㒶ᕈᄌേ䈮䉋䉎ㆇേቇ⠌⹏ଔᴺ䈱ᬌ⸛㩿㪈㪀䇹㩷ᬀ⼱ᰵ਽䇮Ꮉ෶ᢅ↵䇮᩿␽㓷䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P15㩷㩷䋶䋮䇸ฝඨ⃿⊹⾰䈲ᗵᖱ䉕༚ᄬ䈘䈞䈭䈇㩷䋭䊝䊉䉝䊚䊮␹⚻䈮ᡰ䈋䉌䉏䈢䊂䊐䉤䊦䊃䊝䊷䊄䊈䉾䊃䊪䊷䉪઒⺑䋭䇹㩷੹੗⛗⟤ሶ䇮

᩿␽㓷䇮Ꮉේ㕏ᒄ䇮㑐໪ሶ䇮Ꮉ෶ᢅ↵䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P17㩷㩷䋷䋮䇸⾈䈇‛ⴕὑ䈱੺⼔੍㒐ലᨐ䇹㩷Ꮉේ㕏ᒄ䇮੹੗⛗⟤ሶ䇮᩿␽㓷䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P19

㩷䋸䋮䇸ⷡ㉕⊛൬䈇ೝỗ䈮䉋䉎㒰∩ലᨐ䇹㩷ဌ၂෹⟤䇮᩿␽㓷䇮Ꮉේ㕏ᒄ䇮ቝ૒⟤⋿䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P21㩷

㩷䋹䋮䇸cPA ߦࠃࠆᶏ㚍ߩㆃ⊒ᕈ␹⚻⚦⢩ᱫᛥ೙ലᨐ૞↪ߩಽሶᯏ᭴ߩ⸃᣿䇹㩷    ೨↰᩵‫ޔ‬ᓟ⮮⌀㉿‫ޔ‬ၳ↰᥍⟤‫ޔ‬ቶફᡌ‫ޔ‬ቶફ߈ߺሶ䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶䊶P23

ᜰው┵⣂ᵄ⸃ᨆߦࠃࠅផቯߐࠇࠆ࡙࡯ࠩߩ⁁ᘒߦㆡᔕേ૞ߔࠆ࠰ࡈ࠻࠙ࠚࠕ᭴▽ߩ⹜ߺ       ᣂ੗ 㛁 1, የᐔ ๺ਭ 1, ᚭㄝ ⟵ੱ 1, 㓶ጊ ⌀ᑿ 2
1᧲੩㔚ᯏᄢቇ ᧂ᧪⑼ቇㇱ ‫᧲ޥ‬੩ㇺජઍ↰඙␹↰㍪↸ 2ᄢ㒋ᄢቇ ၮ␆Ꮏቇ⎇ⓥ⑼ ‫ ޥ‬ᄢ㒋ᐭ⼾ਛᏒᓙ౗ጊ↸                email:arashun@u-netlab.jp
Keywords: ࠬࡑ࡯࠻ࡈࠜࡦ ⣂ᵄ Application programming interfaceⷐᣦㄭ ᐕ ࠬ ࡑ ࡯ ࠻ ࡈ ࠜ ࡦ ߪ ࡊ ࡠ ࠮ ࠶ ࠨ ߩ 㜞 ᕈ ⢻ ൻ ߿ 㔚 Ḯ ߩ ዊ ဳ ൻ ߦࠃ ࠅ 㜞 ޿ ಣ ℂ ⢻ ജ ࠍ ᜬ ߟ ࠃ ߁ ߦ ߥ ߞ ߚ ߘ ߩ ߚ ߼ ᭽ ‫ࠤ ࡝ ࡊ ࠕ ߥ ޘ‬࡯ ࠪ ࡚ ࡦ ࠍ ޿ ߟ ߢ ߽ ߤ ߎ ߢ ߽ ೑ ↪ ߔ ࠆ ߎ ߣ ߇ น ⢻ ߢ ޽ ࠆ ߒ ߆ ߒ ࡙࡯ ࠩ ߦ ߣ ߞ ߡ ਇ ⷐ ߥ ࡔ ࡯ ࡞ ࠍ ฃ ା ߒ ߚ ࠅ ਇ ᔅ ⷐ ߥ ࠨ ࡯ ࡆ ࠬ ߇ ឭ ଏߐ ࠇ ࠆ ߥ ߤ ࠬ ࡑ ࡯ ࠻ ࡈ ࠜ ࡦ ߪ ࡙ ࡯ ࠩ ߩ ᗧ ᔒ ߣ ߪ ή 㑐 ଥ ߦ ࠦ ࡦ ࡇ ࡘ࡯ ࠹ ࠖ ࡦ ࠣ ࠍ ⴕ ߥ ߞ ߡ ޿ ࠆ ߘ ߩ ߚ ߼ ࡙ ࡯ ࠩ ߦ ߣ ߞ ߡ ᦭ ⋉ ߥ ࠨ ࡯ ࡆࠬ ࠍ ឭ ଏ ߔ ࠆ ߚ ߼ ߦ ߪ ࡙ ࡯ ࠩ ⥄ り ߩ ⁁ ᘒ ࠍ ផ ቯ ߔ ࠆ ߎ ߣ ߇ ᔅ ⷐ ߣߥ ࠆ ߘ ߎ ߢ ᧄ ⎇ ⓥ ߢ ߪ ࡙ ࡯ ࠩ ߩ ⁁ ᘒ ࠍ ផ ቯ ߒ ߡ ㆡ ᔕ േ ૞ ߔ ࠆ ࠰ࡈ ࠻ ࠙ ࠚ ࠕ ߩ ᭴ ▽ ࠍ ⋡ ᜰ ߔ ࡙ ࡯ ࠩ ߩ ⁁ ᘒ ࠍ ᛠ ី ߔ ࠆ ߚ ߼ ߦ ߪ ᜰ ውኈⓍ⣂ᵄࠍ㕖✢ᒻ⸃ᨆߔࠆߎߣߦࠃࠅᓧࠄࠇࠆࠕ࠻࡜ࠢ࠲ߩ゠㆏ߩࠁ ࠄ ߉ ࠍ ↪ ޿ ࠆ ੹ ࿁ ߪ ߘ ߩ ৻ ⹜ ߺ ߣ ߒ ߡ ࡙ ࡯ ࠩ ߩ ♖ ␹ ⁁ ᘒ ࠍ ផ ቯߔ ࠆ ࠕ ࡞ ࠧ ࡝ ࠭ ࡓ ࠍ ᭴ ▽ ߒ ታ 㓙 ߦ ᧄ ࠕ ࡞ ࠧ ࡝ ࠭ ࡓ ↪ ޿ ߡ #2+ ࡜ ࠗ ࡉ࡜ ࡝ ࠍ ⸳ ⸘ ߒ ߚ ߘ ߒ ߡ ᧄ #2+ ࠍ ↪ ޿ ߡ #PFTQKF ┵ ᧃ ਄ ߦ ࡔ ࡯ ࡞ ࡈࠖ ࡞ ࠲ ࡝ ࡦ ࠣ ࠪ ࠬ ࠹ ࡓ ࠍ ታ ⵝ ߒ ߚ ੹ᓟߩዷᦸ੹ᓟࠃࠅᄙߊߩ࠺࡯࠲ࠍ෼㓸ߒߡ⹏ଔࠍขࠆߦ޽ߚࠅࡔ࡯࡞ࡈࠖ࡞࠲࡝ࡦ
ࠣࠪࠬ࠹ࡓࠍ೑↪ߒߡ✚ว⊛ߥታ㛎ࠍⴕ߁ᔅⷐ߇޽ࠆ߹ߚࡈࠖ࡞࠲࡝ࡦࠣ
♖ᐲࠍᡷༀߔࠆߚ߼ߦࡔ࡯࡞ࡈࠖ࡞࠲࡝ࡦࠣࠕ࡞ࠧ࡝࠭ࡓߦࠠ࡯ࡢ࡯࠼ߏߣ
ߦ㊀ߺࠍઃߌࠆᔅⷐ߇޽ࠆߘߒߡᧄ #2+ ࠍ↪޿ߡ࠽ࡆࠥ࡯࡚ࠪࡦ߿ࡋ࡞ࠬࠤ
ࠕߥߤࠍ⋡⊛ߣߒߚᣂߒ޿࠰ࡈ࠻࠙ࠚࠕࠍታⵝߒ᦭↪ᕈࠍᬌ⸽ߒߡ޿߈ߚ޿

－1－ᐔဋ࡝ࠕࡊࡁࡈᜰᢙ㧦♖␹⊛⽶⩄㧦ૐ޿ᐔဋ࡝ࠕࡊࡁࡈᜰᢙ㧦♖␹⊛⽶⩄㧦㜞޿࿑ 1. ࠕ࠻࡜ࠢ࠲゠㆏ߦ߅ߌࠆᐔဋ࡝ࠕࡊࡁࡈᜰᢙߩᲧセ

࿑ 2. ᜰውടㅦᐲ⣂ᵄߩ๟ᵄᢙᚑಽ

－2－

Android Phone

Personal Computer
BluetoothInterface

Interface

CSV Data Analysis
data
ModuleAPI
Data Storage

Application 1
Application 2
Application 3

Application
Controller

Data
Extraction
ModulePulse wave data
A/D Converter

Application …

Pulse Oximeter࿑ 3. ࠪࠬ࠹ࡓࠕ࡯ࠠ࠹ࠢ࠴ࡖ

࿑ 4. ࡄ࡞ࠬࠝࠠࠪࡔ࡯࠲࡯
⴫ 1. API ߩ৻ⷩ䊜䉸䉾䊄ฬ
getHealth()
getData()
getDataAll()
getDataAVG()
getDataAVGAll()
getLyapunov()
getLFHF()ᓎഀ♖␹⁁ᘒࠍ್ቯ㧔Good or Bad㧕ᜰቯߒߚ⣂ᵄ࠺࡯࠲ࠍขᓧ
⣂ᵄ࠺࡯࠲ࠍోߡขᓧ
ᜰቯߒߚ⣂ᵄ࠺࡯࠲ߩᐔဋࠍขᓧ
⣂ᵄ࠺࡯࠲ࠍోߡᐔဋൻߒߡขᓧ
࡝ࠕࡊࡁࡈᜰᢙࠍขᓧ
LF/HFᲧࠍขᓧ

－3－

Loading data
From API

Mental
State

Good

Bad
A:sender’s address
S: mail subject
B: mail body
goodAccountList:a list of preferred senders
goodWordList:a list of important words
badWordList:a list of unimportant words

Yes

goodWordList
include S or B?

No

goodAccountList
include A?

No

Yes

Stock the mailbadWordList
include S or B?

Yes

No
Receive the mail

࿑ 5. ࡔ࡯࡞ࡈࠖ࡞࠲࡝ࡦࠣࠕ࡞ࠧ࡝࠭ࡓ

࿑ 6. ࡔ࡯࡞ࡈࠖ࡞࠲࡝ࡦࠣߩ⸳ቯ↹㕙－4－

Pull all stored
mails if availableᏒⴝ࿾ߦ߅ߌࠆᏅಽࠬ࠹࡟ࠝࠍ↪޿ߚੱᵹ⸘᷹ታ㛎ᩊ↰㓷⡡ 1, ᦭ᳯ⺈ 1, ↢ᒻᔀ 1, ࡕࡠ࡮ࠕ࡟࠶ࠨࡦ࠼ࡠ 1,⷏ᧄ㦖ᒄ 2, ኹᨋ⾫ม 1, ᚭㄝ⟵ੱ 2, ᪢↰๺᣹ 11ਛᄩᄢቇ   ℂᎿቇㇱ ᧲੩ㇺᢥ੩඙ᤐᣣ 1-13-27
  2 ᧲੩㔚ᯏᄢቇ  ᧂ᧪⑼ቇㇱ ᧲੩ㇺජઍ↰඙␹↰㍪↸ 2-2
           email: shibata@sensor.mech.chuo-u.ac.jp
Keywords: ࠬ࠹࡟ࠝࠞࡔ࡜ੱᵹ⸘᷹ࠞ࡞ࡑࡦࡈࠖ࡞࠲KLTⷐᣦᧄⓂߢߪ㧘⟲㚍⋵㙚ᨋᏒߢ㐿௅ߐࠇߚ╙ 40 ࿁㙚ᨋ߹ߟࠅߦ߅ߌࠆੱᵹ⸘᷹ߩ
ታ㛎⚿ᨐࠍႎ๔ߒߡ޿ࠆ㧚ᚒ‫ߪޘ‬వⴕ⎇ⓥߦ߅޿ߡ㧘⸘᷹ኻ⽎ࠍ⒖േ‛૕ߦ೙㒢ߔࠆᏅಽࠬ࠹࡟ࠝߣ๭߫
ࠇࠆਃᰴర⸘᷹ᚻᴺࠍ↪޿ߚᱠⴕ⠪ᬌ಴ࠍឭ᩺ߒߡ޿ࠆ㧚ੱᵹ⸘᷹ߦߪ㧘ߎߩᏅಽࠬ࠹࡟ࠝࠍ᜛ᒛߒߡ߽ߜ޿ߡ޿ࠆ㧚ᷙ㔀ᐲวߦᔕߓߚ
ੑߟߩੱᵹ⸘᷹ᚻᴺߣߒߡ㧘ࠞ࡞ࡑࡦࡈࠖ࡞࠲ߦࠃࠅㅊ〔ߐࠇߚੱ‛ߩ૏⟎ߣㅦᐲ߆ࠄੱᢙߣ⒖േᣇะࠍ▚಴ߔࠆᚻᴺߣ㧘KLT(Kanade-Lucas-Tomasi Tracker)ߣࡏࡠࡁࠗಽഀࠍ↪޿ߡੱᢙߣ⒖േᣇะࠍ▚಴ߔࠆᚻᴺࠍ↪޿ߡ޿ࠆ㧚ታ㛎⚿ᨐߣߒߡ㧘⸘᷹ᤨ㑆ౝߩᱠⴕ⠪ᢙߩផ⒖ߣ޿ߞߚੱߩᵹࠇߩ௑ะࠍข
ᓧߢ߈ߚ㧚

੹ᓟߩዷᦸᧄታ㛎ߢߪ㧘ੱߩᵹࠇߩ௑ะࠍขᓧߢ߈ߡ޿ࠆ߇㧘ᱜ⏕ߥᱠⴕ⠪ᢙࠍ⸘᷹ߢ
߈ࠆߦߪ⥋ߞߡ޿ߥ޿㧚ߎࠇߪੱ‛߇↹㕙਄ߢ㊀ߥߞߡߒ߹ߞߡ޿ࠆ႐ว㧘ੱᢙߩ⸘᷹߇ᱜߒߊⴕ߃ߥ޿ߎߣ߇ේ࿃ߣߥߞߡ޿ࠆ㧚ࠃߞߡ੹ᓟߪ㧘ࠝࠢ࡞࡯࡚ࠫࡦࠍ⠨ᘦߒߚੱᢙផቯࠍⴕ߁ߎߣߢ㧘ࠃࠅ㜞♖ᐲߥੱᵹ⸘᷹ࠍታ⃻ߔࠆ㧚

－5－   (a)ࠞ࡞ࡑࡦࡈࠖ࡞࠲    
 (b) KLT ߣࡏࡠࡁࠗಽഀ
Fig.1 ಴ജ↹௝㧦ੱᵹ⸘᷹ࠍⴕߞߡ޿ࠆ᭽ሶ
KLT and Voroni diagram
Measured value of Right
True value of Right
Measured value of Left
True value of Left

Number of pedestrian

Number of pedestrian

Kalman filter
18
17
16
15
14
13
12
11
10
9
8
7
6
5
4
3
2
1
0

Time

18
17
16
15
14
13
12
11
10
9
8
7
6
5
4
3
2
1
0

Measured value of Right
True value of Right
Measured value of Left
True value of Left

Time

Fig.2 Ꮐฝᣇะߦ⒖േߒߡ޿ࠆᱠⴕ⠪ᢙߩ⸘᷹⚿ᨐ－6－๭ๆ࠮ࡦࠪࡦࠣߩ↢ℂቇ⊛ᗧ⟵ߣߘߩᣣᏱᔕ↪
ᮑႩ Ꮁॳ䴪ᓬ ⠛Ḥ⼹䲙 㕙ᖫ‫ ؝‬ ␹ᚭᄢቇ ࠪࠬ࠹ࡓᖱႎቇ⎇ⓥ⑼ ␹ᚭᏒἥ඙౐↲↸㧝㧙㧝᡼ㅍᄢቇ ᢎ㙃ቇㇱජ⪲Ꮢ⟤ᵿ඙⧯⪲           ᖱႎㅢା⎇ⓥᯏ᭴           email: shiyipp@yahoo.co.jp
Keywords: ๭ๆ࠮ࡦࠪࡦࠣ ࠬ࠻࡟ࠬ ᷓ๭ๆ ੤ᗵ␹⚻ᵴേⷐᣦࠬ࠻࡟ࠬߦ⿠࿃ߔࠆ㜞ⴊ࿶‫ޔ‬ᔃ╭᪪Ⴇ‫ޔ‬ᔃ⤳∛=?‫ޔ‬⣖තਛߥߤߩ∔ᖚ߇໧㗴ߣߥߞߡ޿ࠆ‫ߩࠬ࡟࠻ࠬޕ‬Ⴧടߦ઻޿‫ޔ‬੤ᗵ␹⚻ᵴേ߇੣ㅴߔࠆߎߣ߇⍮ࠄࠇߡ߅ࠅ‫ޔ‬ஜᐽ⛽ᜬߩߚ߼ߦߪ‫ޔ‬ᣣᏱ↢ᵴߦ߅޿ߡ‫ޔ‬੤ᗵ␹⚻ᵴേߩᛥ೙ߦࠃ
ࠆ⥄ᓞ␹⚻ߩ⺞▵ࠍߔࠆߎߣ߇ᔅⷐߢ޽ࠆ‫ޕ‬ᧄ⎇ⓥߪ‫ޔ‬๭ๆ࠮ࡦࠪࡦࠣࠍㅢߓߡੱߩ๭ๆ⁁ᘒࠍⷰኤߒ‫ߦࠬ࡟࠻ࠬޔ‬ᤴߐࠇߚߣ߈ߦ‫ޔ‬㓐ᗧ๭ๆߦࠃࠅ‫ޔ‬੤ᗵ␹⚻ᵴേࠍᛥ೙ߢ߈ࠆߎߣࠍⴊ࿶‫ޔ‬ᔃᜉ‫ޔ‬ᜰው⣂ᵷ‫⤏⊹ޔ‬વዉᐲ‫ޔ‬⣖ᵄ᷹ቯߦࠃࠅ⏕⹺ߒߚ‫߇ࠬ࡟࠻ࠬޕ‬り૕⊛‫⊛␹♖ޔ‬ߦട߃ࠄࠇࠆߣ‫ߚߒ࠴࠶ࡖࠠࠍࠇߘޔ‬⣖߇‫ޔ‬೽⣢㜑⾰߆ࠄߩࠕ࠼࡟࠽࡝ࡦಽᴲ
ߣหᤨߦ‫ޔ‬੤ᗵ␹⚻ᵴേߩ੣ㅴߣ޿߁ᜰ઎ࠍ಴ߔ‫ޕ‬⢖િዷ෻኿ࠍ઻߁ᷓ޿๭ๆ
ߪ‫ޔ‬೽੤ᗵ␹⚻ᵴേࠍ੣ㅴߒᜟ᛫ߔࠆ੤ᗵ␹⚻ᵴേ߇ᛥ೙ߐࠇࠆߎߣࠍ೑↪ߒߚ‫ޕ‬੹ᓟߩዷᦸ ⢖િዷ෻኿ࠍ઻߁ᷓ޿๭ๆߦࠃࠅ‫ޔ‬๭ๆߣᔃᜉᢙᄌൻߦ߅ߌࠆᒝ޿
หᦼ‫ޔ‬⣖ᵄ ǩ ᵄᚑಽߩᵴᕈ‫ⴊޔ‬࿶ߩㅦ߿߆ߥૐਅ‫ޔ‬ᔃᜉᄌേߦ߅ߌࠆ .(ᚑಽߩᛥ೙ߣ๭ๆ๟ᵄᢙᚑಽߩ෻ᤋ߇ⷰኤߐࠇ‫⥄ߪࠄࠇߎޔ‬ᓞ␹⚻ߩ⺞ᢛ߇ⴕࠊࠇߚߎߣࠍ෻ᤋߒߡ޿ࠆߣ⠨߃ࠄࠇࠆ‫ޕ‬ᣣᏱߦ߅ߌࠆ๭ๆߩ⁁ᘒࠍᛠីߒ‫✕ޔ‬ᒛᤨ߿ࠬ࠻࡟ࠬ⽶⩄ᤨߦ‫ޔ‬๭ๆ⺞ᢛࠍଦߔߎߣ߇ᗧ๧߇޽ࠆߎ
ߣߢ޽ࠆน⢻ᕈ߇␜ໂߐࠇߚ‫ޕ‬－7－๭ๆ࠮ࡦࠪࡦࠣߩ↢ℂቇ⊛ᗧ⟵ߣߘߩᣣᏱᔕ↪
ᣉ⤪1, Ꮉේ㕏ᒄ2 ,᩿␽㓷3 ,⟜ᔒஉ1 , (␹ᚭᄢቇ1 ,᡼ㅍᄢቇ2 ,ᖱႎㅢା⎇ⓥᯏ᭴3)⎇ⓥ䈱⢛᥊䈫⋡⊛䉴䊃䊧䉴䈮⿠࿃䈜䉎㜞ⴊ࿶䇮ᔃ╭᪪Ⴇ䇮ᔃ⤳∛[1] 䇮⣖තਛ䈭䈬䈱∔ᖚ䈏໧㗴䈫䈭䈦䈩䈇䉎䇯䉴䊃䊧䉴䈱Ⴧട䈮઻䈇䇮੤ᗵ␹⚻ᵴേ䈏੣ㅴ䈜䉎䈖䈫䈏⍮䉌䉏䈩䈍䉍䇮ஜᐽ⛽ᜬ䈱䈢䉄䈮䈲䇮ᣣᏱ↢ᵴ䈮䈍䈇䈩䇮੤ᗵ␹⚻ᵴേ䈱ᛥ೙䈮䉋䉎⥄ᓞ␹⚻䈱⺞▵䉕䈜䉎䈖䈫䈏ᔅⷐ䈪䈅䉎䇯䉕䈜䉎ᔅⷐ 䈅䉎䇯
ᧄ⎇ⓥ䈲䇮๭ๆ䉶䊮䉲䊮䉫䉕ㅢ䈛䈩ੱ䈱๭ๆ⁁ᘒ䉕ⷰኤ䈚䇮䉴䊃䊧䉴䈮ᤴ䈘䉏䈢䈫䈐䈮䇮㓐ᗧ๭ๆ䈮䉋䉍䇮੤ᗵ␹⚻ᵴേ䉕ᛥ೙䈪䈐䉎䈖䈫䉕ⴊ࿶䇮ᔃᜉ䇮ᜰው⣂ᵷ䇮⊹⤏વዉᐲ䇮⣖ᵄ᷹ቯ䈮䉋䉍⏕⹺䈚䈢䇯䉴䊃䊧䉴䈏り૕⊛䇮♖␹⊛䈮ട䈋䉌䉏䉎䈫䇮䈠䉏䉕䉨䊞䉾䉼䈚䈢⣖䈏䇮೽⣢㜑⾰䈎䉌䈱䉝䊄䊧䊅䊥䊮ಽᴲ䈫หᤨ䈮䇮੤ᗵ␹⚻ᵴേ䈱੣ㅴ䈫䈇䈉ᜰ઎䉕಴䈜䇯⢖િዷ෻኿䉕઻䈉ᷓ䈇๭ๆ䈲䇮೽੤ᗵ␹⚻ᵴേ䉕੣ㅴ䈚ᜟ᛫䈜䉎੤ᗵ␹⚻ᵴേ䈏ᛥ೙䈘䉏䉎䈖䈫䉕೑↪䈚䈢䇯
䉅䈚㜞CO2䈏⿠䈖䉎䈭䉌䇮๭ๆ䈲Ⴧᄢ䈜䉎䇯䈖䈱 ⚿ᨐ䈫⠨ኤ䈫䈐෻኿⊛䈮੣ㅴ䈚䈩䈇䉎䈖䈫䈏䈅䈦䈩䇮๭ๆ䈲ᕷ⧰䈚䈘䉕ᗵ䈛䉎䇯ᑧ㜑䋨⣖ᐙ䋩䈎䉌䈱ାภ䈏II䈱⣖ᵄ⚻〝䈮ㅍ䉌䉏䉎䇯
⢖િዷฃኈེ䈲᳇▤䉇᳇▤ᡰ䈱᳇㆏ო䈮ሽ࿷䈚䇮⢖ኈ㊂䈱Ⴧᄢ䈏㗼⪺䈮䈭䉎䈫෻ᔕ䈚䇮䈖䉏䉴䊃䊧䉴䊁䉴䊃䋱ᓟ䈮ㅢᏱ๭ๆ 䉴䊃䊧䉴䊁䉴䊃䋲ᓟ䈮ᷓ䈇๭ๆએ਄䈱ๆᕷ䉕ᛥ೙䈜䉎䇯[2]䉕䈜䉎䈫䇮䌏䋱䇮䌏䋲䋨ᓟ㗡ㇱ䋩䈮 䈜䉎䈫䇮䋱䋰䌈䌺䌾䋱䋳䌈䌺Ꮺᚑಽ
䋨Hering-Breuer ෻኿䋩䈍䈇䈩䇮䋱䋰䌈䌺䌾䋱䋳䌈䌺Ꮺ䈱ᚑ 䈲䈇䈧䉅ᒝ䈒಴⃻䈚䈢䇯Υb䋬Υ-1䈱⚻〝ಽ䈲ᒙ䈇䇯ᣇᴺ⢖િዷ෻኿䉕઻䈉ᷓ䈇๭ๆ䈮䉋䉎↢ℂᖱႎ䈱ᄌൻ䉕⸘᷹䋨䉴䊃䊧䉴⽶⩄ᓟ䋩ⵍ㛎⠪䋺 䋲䋰ઍ䇮ஜᐽ䈭ᅚᕈ 䋨⸘᷹ᣇᴺ⏕┙䈱䈢䉄䈱䊌䉟䊨䉾䊃䊶䉴䉺䊂䉞䋩᷹ቯ㗄⋡䋺๭ๆ䇮ⴊ࿶䇮ໜᶧ䉝䊚䊤䊷䉷䇮ᜰው⣂ᵷ䇮⊹⤏વዉᐲ
᷹ቯᣇᴺ
᷹ቯᣇᴺ䋺

䉴䊃䊧䉴䊁䉴䊃䋱
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㽲

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㽲Ḱ஻
㽳⸘▚䉴䊃䊧䉴䊁䉴䊃䋨䋱䋰ಽ䋩㽴ᷓ䈇๭ๆ䈪䊥䊤䉾䉪䉴䋨䋲䋰ಽ䋩* ✛䋺 SC 䉥䊧䊮䉳䋺 BVP

⿒䋺HR: BVP 㤛⦡䋺 HR/RSP㕍䈇䋺 RSP 䉴䉦䊷䊧䉾䊃䋺 EEG๭ๆ৻࿁឵᳇㊂䋺450mL䋨ㅢᏱ๭ๆ䋩䇮1200mL䋨ᷓ䈇๭ๆ䋩
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ㅢᏱ๭ๆ

L

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Time: secໜᶧ䉝䊚䊤䊷䉷

DIA

SYS

150

100

100

ໜᶧ䉝䊚䊤䊷䉷

010䉴䊃䊧䉴䊁䉴䊃䋲

20

0
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10
20
䉴䊃䊧䉴䊁䉴䊃ਛ䈲ⴊ࿶䈏㜞䈒䇮䊁䉴䊃ᓟ䈱ᷓ䈇๭ๆ䈮䉋䉍䇮ⴊ࿶䈱ᢵᔉᳳ䈏Ყセ⊛ᕆㅦ䈮ૐਅ䈚䈢䇯ໜᶧ䉝䊚䊤䊷䉷䈲䊁䉴䊃ᦨೋ䈫ᓟ䈎䉌5ಽ䈗䈫᷹ቯ䈚䈩䇯䊁䉴䊃ᓟ䈎䉌䇮ਅ䈏䈦䈩䈇䈢䇯

30 -20䉴䊃䊧䉴䊁䉴䊃ਛ䈲䇮ⴊ࿶䈱ᢵᔉᳳ䈲㜞䈒䇮䊁䉴䊃ᓟ䈱቟㕒䈮઻䈇ૐਅ䈚䈢ঢ㐂ᳳ䈲䈅䉁䉍ᄌൻ䈚䈭䈎䈦䈢䇯ໜᶧ䉝䊚䊤䊷䉷䈲䊁䉴䊃ᓟ5ಽ䈎䉌5ಽ䈗䈫᷹ቯ䈚䈩䇮ᦨೋ䈲䈅䈏䈦䈩䇮ᓟਅ䈏䈦䈩䈇䈢䇯䉴䊃䊧䉴⽶⩄೨੤ᗵ␹⚻ᵴേ䈲䇮ዋ䈚੣ㅴ䈚䈩䈇䉎䇯䉴䊃䊧䉴⽶⩄ਛ੤ᗵ␹⚻ᵴേ䈏䈘䉌䈮੣ㅴ䈚䈢䇯䉴䊃䊧䉴⽶⩄ᓟ੤ᗵ␹⚻ᵴേ䈏੣ㅴ䈚䈢䉁䉁䈪䈅䉎䇯ᷓ䈇๭ๆ䈮䉋䉍䇯੤ᗵ␹⚻ᵴേ䉕෻ᤋ䈜䉎LFᏪ䈱୯䈲ૐਅ䈚䈢䇯ੑ࿁䈱䉴䊃䊧䉴䊁䉴䊃ᓟ䈲䈠䉏䈡䉏ㅢᏱ๭ๆ䈫ᷓ䈇๭ๆ䉕䈚䈢䇯⚿ᨐ䈲䇮ᷓ䈇๭ๆ䈜䉎䈫䇮䉴䊃䊧䉴䈏ㅦ䈒࿁ᓳ䈪䈐䉕䈚䈢⚿ᨐ䈲 ᷓ䈇๭ๆ䈜䉎䈫 䉴䊃䊧䉴䈏ㅦ䈒࿁ᓳ䈪䈐䈩䈇䉎䈖䈫䉕⴫䈚䈩䈇䉎䇯ⴊ࿶䈲䇮ㅢᏱ๭ๆ䉋䉍ᷓ䈇๭ๆ䈱䈾䈉䈏ਅ䈏䈦䈩䈇䈢䉴䊏䊷䊄䈏ㅦ䈇䇯
ᷓ䈇๭ๆ䈜䉎䈫䇮䌂䌖䌐䈱ᝄ᏷䈲ᄢ䈐䈒䈭䉍䇮๭ๆ䈮ห⺞䈚䈢䇯ᔃᜉᄌേ䉴䊕䉪䊃䊦䈮䈍䈇䈩䇮䉴䊃䊧䉴⽶⩄ᓟ䈱቟㕒䈪䇮੤ᗵ␹⚻ᵴേ䉕෻ᤋ䈜䉎LFᏪ䈱ᚑಽ䈱䊌䊪䊷䈲ዊ䈘䈒䈭䉌䈭䈎䈦䈢䈏䇮ᷓ䈇๭ๆ䈮䉋䉍䇮LFᏪ䈱ᚑಽ䈱䊌䊪䊷䈏ዊ䈘䈒䈭䉍䇮⥄ᓞ␹⚻䈱⺞ᢛ䈏䈭䈘䉏䈢䈫⷗ㄟ䉁䉏䉎䇯

ෳ⠨ᢥ₂

50

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-10

DIA

150

50

-20

䉴䊃䊧䉴䊁䉴䊃䋱

䉁䈫䉄ᷓ䈇๭ๆ

Time: sec

SYS㪟㪩㪭⸃ᨆ䉕↪䈇䈩䇮ੑ࿁䈱䉴䊃䊧䉴ታ㛎䈮੤ᗵ␹⚻ᵴേ䈱ᄌൻ䉕⏕⹺䈚䈢[3] 䇯䉴䊃䊧䉴䊁䉴䊃䋲㽲Ḱ஻㽳⸘▚䉴䊃䊧䉴䊁䉴䊃䋨䋱䋰ಽ䋩㽴ㅢᏱ๭ๆ䈪䊥䊤䉾䉪䉴䋨䋳䋰ಽ䋩

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HRV⸃ᨆ䋨䉴䊕䉪䊃䊦䋩－8－[1] Tsugiyoshi, MD : Central Sympathetic Inhibition Augments
Sleep-related Ultradian Rhythm of Parasympathetic Tone inPatients With Chronic Heart Failure, Circ J, Vol.69, pp 10521056 (2005)[2] 䉦䊤䊷࿑⸃ 䉋䈒䉒䈎䉎↢ℂቇ䈱ၮ␆ 䊜䊂䉞䉦䊦䊶䉰䉟䉣䊮䉴䊶䉟䊮䉺䊷䊅䉲䊢䊅䊦, 䌰䌰䋱䋳䋲[3]Nozomi Sato Shinji Miyake: Cardiovascular Reactivity to
Mental Stress: Relationship with Menstrual Cycle and Gender,
Journal of physiological anthropology and applied humanscience, Vol. 23(6), pp. 215-223 (2004)ᖱႎㅢାᛛⴚࠍ↪޿ߚ㖸ᭉ≮ᴺ㧔ᄢ㊂ߩᣉⴚᖱႎߦࠃࠆലᨐ⹏ଔߣ
㖸ᭉ≮ᴺ࠺࡯࠲࡮ࡑࠗ࠾ࡦࠣ㧕ዊ᧖ዏሶ 1, ᢙ੗⵨శ 2, ㄭ⮮⌀↱ 3, ↰ㇱ੗⾫৻ 4, ⇌㓷ਯ 5,



 1
NTT
2

ࠦࡒࡘ࠾ࠤ࡯࡚ࠪࡦ⑼ቇၮ␆⎇ⓥᚲ ␹ᄹᎹ⋵ෘᧁᏒ᫪ߩ㉿⧯ች 3-1ᄢ㒋ᄢቇᄢቇ㒮කቇ♽⎇ⓥ⑼♖␹කቇಽ㊁ ᄢ㒋ᐭ็↰Ꮢጊ↰ਐ 2-2 D3
3᧲ᶏᄢቇᢎ㙃ቇㇱ⧓ⴚቇ⑼㖸ᭉቇ⺖⒟ ␹ᄹᎹ⋵ᐔႦᏒർ㊄⋡㧠-㧝㧝
4ᣣᧄᄢቇᄢቇ㒮✚ว⑼ቇ⎇ⓥ⑼ ᧲੩ㇺජઍ↰඙੖⇟↸㧝㧞㧙㧡
5․ቯ㕖༡೑ᵴേᴺੱർᶏ㆏ࡑࠗࠢࡠࡆࠫࡀࠬផㅴද⼏ળ ᧅᏻᏒਛᄩ඙
ർ㧝᧦᧲㧞ৼ⋡㧡㧙㧤 ╙ੑ㆙⮮ࡆ࡞㧠FSCOOP                email: kosugi.naoko@lab.ntt.co.jp     

Keywords: 㖸ᭉ≮ᴺ ᖱႎㅢାᛛⴚ ലᨐ⹏ଔ 㖸ᭉ≮ᴺ࠺࡯࠲࡮ࡑࠗ࠾ࡦࠣ

ⷐᣦᧄ⎇ⓥߢߪ‫ޔ‬㖸ᭉ≮ᴺߩലᨐࠍ⑼ቇ⊛ߦ᣿ࠄ߆ߦߔࠆߎߣ‫ࠅࠃ߮ࠃ߅ޔ‬ലᨐ⊛ߥ㖸ᭉ≮ᴺࠍⴕ߁ߚ߼ߦߪ૗߇ᔅⷐ߆ࠍ⸃᣿ߔࠆߎߣࠍ⋡ᜰߔ‫⹺ޕ‬⍮∝ߩ๟ㄝ∝⁁ߦኻߔࠆ㕖⮎‛≮ᴺߩ㧝ߟߣߒߡ‫ޟ‬㖸ᭉ≮ᴺ‫ᦨޕࠆ޽߇ޠ‬ㄭߪ㑐ᔃ߇㜞߹ࠅߟߟ޽ࠅ‫᦭ߩߘޔ‬ലᕈߦߟ޿ߡ߽᭽‫ޔ߇ࠆ޽߇࠼࡯࠰ࡇࠛߥޘ‬૗ߦߤߩࠃ߁ߥലᨐ
߇޽ࠆߩ߆᣿ࠄ߆ߦߥߞߡ޿ߥ޿‫⎇ᧄޕ‬ⓥߢߪቴⷰᕈ࡮ା㗬ᕈߩ㜞޿⺑ᓧജߩ޽ࠆലᨐ⹏ଔ⎇ⓥࠍ㆐ᚑߔࠆߚ߼ߦ‫ᦨޔ‬ᣂߩᖱႎㅢା࡮ᖱႎಣℂᛛⴚࠍ↪޿ߡ‫ޔ‬ᄢ㊂ߩ㖸ᭉ≮ᴺߦ㑐ߔࠆ࠺࡯࠲ࠍല₸⊛ߦ෼㓸࡮ಽᨆߔࠆ‫ᧄޕ‬Ⓜߢߪ⃻࿷⸘↹ਛߩലᨐ⹏ଔߩߚ߼ߩᄢⷙᮨή૞ὑഀઃ⥃ᐥ⹜㛎ߣ‫ޔ‬࿷ቛ੺⼔ᡰេߩߚ߼ߩ㆙㓒㖸ᭉ
≮ᴺࠪࠬ࠹ࡓߦߟ޿ߡ‫ᦨޔ‬ᣂߩ⁁ᴫࠍႎ๔ߔࠆ‫ޕ‬੹ᓟߩዷᦸᧄ⎇ⓥߩᚑᨐߦࠃߞߡലᨐ⊛ߥ㖸ᭉ≮ᴺࠍ቟ᔃߒߡฃߌࠄࠇࠆࠃ߁ߦߥࠆߎߣ
ߢ‫ޔ‬㜞㦂⠪ߩ⥄┙߿㧽㧻㧸ะ਄‫⽶⼔੺ߪߡ޿߭ޔ‬ᜂ㧔ੱ࡮⾌↪ߥߤ㧕ߩᄢ᏷ߥシᷫߦ❬߇ࠆߎߣ߇ᦼᓙߐࠇࠆ‫ޕ‬዁᧪⊛ߦߪᧄ⎇ⓥߢ᣿ࠄ߆ߣߥࠆ‫ޟ‬㜞㦂⠪ߩߚ߼ߩലᨐ⊛ߥ㖸ᭉ≮ᴺ‫ߦޠ‬ၮߠ޿ߡ‫ో↢ੱޔ‬૕ߩᐘߖࠍᡰេߔࠆߚ߼ߩ‫ޟ‬ᣣᧄߩ㖸ᭉᢎ⢒ߩᦸ߹ߒ޿࿷ࠅᣇ‫ߩޠ‬ឭ᩺ߦ❬ߍߡ޿߈ߚ޿‫ޔߪࠇߎޕ‬‫ߢߥࠎߺ߽ߢߟ޿ޟ‬᱌߃ࠆ᱌߇޽ࠆ␠ળ‫ࠍޠ‬ታ⃻ߒߚ޿‫߁޿ߣޔ‬ᗧ๧ߢ޽ࠆ‫ޕ‬ᄙߊߩ੺⼔⃻႐ߢߪ 60
ઍ߆ࠄ 90 ઍߩ㜞㦂⠪߇ᭉߒߊ৻✜ߦ㖸ᭉ≮ᴺࠍฃߌߡ޿ࠆ‫ޕ‬30 ᱦㄭߊᱦ߇㔌ࠇߡ޿ߡ߽‫ߦ✜৻ޔ‬᱌߃ࠆ᱌߇޽ࠆߣ޿߁ߎߣߪߣߡ߽ᐘߖߥߎߣߢ޽ࠆ‫ߚߩߘޕ‬߼ߦߪ㖸ᭉᢎ⢒ࠍㅢߒߡ‫ޔ‬㖸ᭉ⊛⢻ജࠍりߦߟߌ‫౒ޔ‬ㅢߒߚ㖸ᭉࠍቇ⠌ߔࠆߎߣ߇ᦸ߹ߒ޿‫ߩߎޕ‬㖸ᭉ≮ᴺߩലᨐ⹏ଔ⎇ⓥࠍㅢߒߡ‫ޔ‬㜞㦂⠪ߦߥߞߚᤨߦ㖸ᭉ≮ᴺࠍฃߌࠆ႐ว‫ߥ߁ࠃߩߤޔ‬㖸ᭉ⊛⢻ജࠍりߦߟߌߡ߅ߊߣ᦭ലߥߩ߆‫ࠃߩߤޔ‬߁ߥ㖸ᭉࠍቇ⠌ߔࠆߣᦸ߹ߒ޿ߩ߆‫ࠍߤߥޔ‬᣿ࠄ߆ߦߔࠆߎߣ߽⋡ᜰߒߚ޿‫ޕ‬－9－

－ 10 －

－ 11 －

－ 12 －

－ 13 －

ᧄ⎇ⓥߪ‫✚ޔ‬ว⑼ቇᛛⴚળ⼏ߦࠃࠅ೙ᐲ⸳⸘ߐࠇߚᦨవ┵࡮ᰴ਎ઍ⎇ⓥ㐿⊒ᡰេࡊࡠࠣ࡜ࡓߦࠃࠅ‫ޔ‬ᣣᧄቇⴚᝄ⥝ળࠍㅢߒߡഥᚑߐࠇߚ߽ߩߢߔ‫ޕ‬－ 14 －

㓐઻ᕈ㒶ᕈᄌേߦࠃࠆㆇേቇ⠌⹏ଔᴺߩᬌ⸛  㧙ࡄࠗࡠ࠶࠻ࠬ࠲࠺ࠖ
ᬀ⼱ᰵ਽ 㧘Ꮉ෶ᢅ↵ 㧘᩿␽㓷 

␹ᚭᄢቇᄢቇ㒮 ଻ஜቇ⎇ⓥ⑼㧘౓ᐶ⋵␹ᚭᏒ㗇⏴඙෹߇ਐ 
⁛┙ⴕ᡽ᴺੱ ᖱႎㅢା⎇ⓥᯏ᭴㧘౓ᐶ⋵␹ᚭᏒ⷏඙ጤጟ↸ጤጟ              email: 097k702k@stu.kobe-u.ac.jp

Keywords㓐઻ᕈ㒶ᕈᄌേㆇേቇ⠌ㆇേࠗࡔ࡯ࠫⷐᣦ ㆇേቇ⠌ߦߪㆇേࠗࡔ࡯ࠫࠍ↪޿ߚ✵⠌߇᦭ലߢ޽ࠆ‫ޔߒ߆ߒޕ‬ㆇേࠗࡔ࡯
ࠫ⢻ജߪ୘ੱᏅ߇޽ࠆߎߣ߇ᜰ៰ߐࠇߡ߅ࠅ‫ߩࠫ࡯ࡔࠗޔ‬㞲᣿ߐ߿♖ᐲ߇ߘߩᓟߩㆇേቇ⠌ߦᓇ㗀ߔࠆน⢻ᕈ߇⠨߃ࠄࠇࠆ‫⎇ᧄޕ‬ⓥߢߪㆇേࠗࡔ࡯ࠫᗐ⿠ਛ
ߦታ㓙ߩㆇേᤨߣ㘃ૃߒߚ⣖ᵄᵄᒻ߇ᓧࠄࠇߡ޿ࠆߎߣ߇ࠗࡔ࡯ࠫߩ㞲᣿ߐ߿♖ᐲ߇㜞޿ߎߣߣ╬ଔߢ޽ࠆߣᗐቯߒ‫ޔ‬੐⽎㑐ㅪ㔚૏ߩ৻ߟߢ޽ࠆ㓐઻ᕈ㒶ᕈ
ᄌേ %08 ࠍ↪޿ߚ⹏ଔᴺߩᬌ⸛ࠍⴕߞߚ‫ޕ‬ஜᏱᚑੱ↵ᕈࠍኻ⽎ߦታ㓙ߩࠬ࠹࠶ࡊㆇേ‫ޔ‬ᱠⴕ‫ࡊ࠶࠹ࠬޔ‬ㆇേࠗࡔ࡯ࠫߩ  ⺖㗴ࠍታᣉߔࠆ㓙ߩ %08 ࠍ⸥㍳ߒߚ⚿ᨐ‫ޔ‬%\‫ޔ‬% ߩ㔚ᭂߢࠬ࠹࠶ࡊㆇേᤨߣࠬ࠹࠶ࡊㆇേࠗࡔ࡯ࠫᤨߩ㑆ߦ %08 ᓟ
ᦼᚑಽ .CVG%08 ᵄᒻߩ㘃ૃᕈࠍ⹺߼ߚ㧔࿑ ‫ޔ‬࿑ 㧕‫ޕ‬ㆇേࠗࡔ࡯ࠫᤨߦߪታ
㓙ߩㆇേᤨߣห᭽ߩ⣖ᵴേ߇↢ߓࠆߎߣ߇ႎ๔ߐࠇߡ߅ࠅ‫⎇ᧄޔ‬ⓥߦ߅ߌࠆࠬ
࠹࠶ࡊ⺖㗴ߢ߽ߘߩߎߣ߇⏕߆߼ࠄࠇߚ‫ޕ‬૕ᕈᗵⷡ⊛ࠗࡔ࡯ࠫߦ߅ߌࠆ⵬⿷ㆇ
േ㊁ߩᵴേߦࠃߞߡ‫ࡊ࠶࠹ࠬޔ‬ㆇേߦᔅⷐߥḰ஻ᵴേ߇↢ߓߡ޿ߚߎߣ߇ .CVG
%08 ߩ㘃ૃᕈߦ❬߇ߞߚน⢻ᕈ߇⠨߃ࠄࠇࠆ‫ޕ‬ታ㓙ߩㆇേߣㆇേࠗࡔ࡯ࠫߩḰ஻ᵴേߦ㘃ૃᕈࠍ⹺߼ߚߎߣߪ‫ޔ‬ㆇേቇ⠌⹏ଔᴺߣߒߡ %08 ߇᦭ᦸߢ޽ࠆน⢻ᕈࠍ␜ໂߔࠆ‫ޕ‬੹ᓟߩዷᦸ ੹ᓟߪㆇേቇ⠌ߩㅴᐲߣ⣖ౝㆇേࠗࡔ࡯ࠫߩᒻᚑߦ⋧㑐߇޽ࠆ߆ߤ߁߆ࠍᬌ
⸛ߔࠆߎߣߢ‫ޔ‬%08 ࠍ↪޿ߡኻ⽎⠪Ფߦㆇേቇ⠌ߩㅴᐲࠍ⹏ଔߢ߈ࠆߎߣࠍ᣿ࠄ
߆ߦߔࠆᔅⷐ߇޽ࠆ‫ޕ‬

－ 15 －

䋨䌭㪭䋩

㪪㪉

㪪㪉

㪌

㪌

㪇

㪇
㪄㪌

䋨䌭㪭䋩

㪌㪇㪇㫄㫊
࿑ ࠬ࠹࠶ࡊㆇേᤨߩ%08ᵄᒻ %㪄㪌࿑ ࠬ࠹࠶ࡊㆇേࠗࡔ࡯ࠫᤨߩ%08ᵄᒻ %

－ 16 －

ฝඨ⃿⊹⾰ߪᗵᖱࠍ༚ᄬߐߖߥ޿
㧙ࡕࡁࠕࡒࡦ␹⚻ߦᡰ߃ࠄࠇߚ࠺ࡈࠜ࡞࠻ࡕ࡯࠼ࡀ࠶࠻ࡢ࡯ࠢ઒⺑㧙੹੗⛗⟤ሶ 1,᩿␽㓷 2, Ꮉේ㕏ᒄ 3, 㑐໪ሶ 1, Ꮉ෶ᢅ↵ 11␹ᚭᄢቇᄢቇ㒮 ଻ஜቇ⎇ⓥ⑼ ౓ᐶ⋵␹ᚭᏒ㗇⏴඙෹߇ਐ 7-10-2⁛㧕ᖱႎㅢା⎇ⓥᯏ᭴ᧂ᧪ ICT ⎇ⓥᚲ ౓ᐶ⋵␹ᚭᏒ⷏඙ጤጟ↸ጤጟ 588-2
3᡼ㅍᄢቇᄢቇ㒮 ᢥൻቇ⎇ⓥ⑼ ජ⪲⋵ජ⪲Ꮢ⟤ᵿ඙⧯⪲ 2-12            email: emikoimai@stu.kobe-u.ac.jp

Keywords: ࡊࡠ࠰࠺ࠖ ࠬ࠻࡟ࠬ 㖸㗀ಽᨆ ၮᐙ⣖ ࡕࡁࠕࡒࡦ

ⷐᣦੱߩ⹤ߒ⸒⪲ߦ฽߹ࠇࠆࡊࡠ࠰࠺ࠖ㧔㖿ᓞ㧕ߪ‫ޔ‬⣖៊்ߦࠃߞߡ㓚ኂߐࠇࠆߎߣ߇޽ࠆ‫ޕ‬Ꮐඨ⃿ߩ⸒⺆ࠍ฽߻㗔㊁ߩㇱ૏ߩ៊்ߦࠃߞߡ↢ߓࠆࡊࡠ࠰࠺ࠖ
↥↢㓚ኂߪᄬ⺆∝ߩࠃ߁ߥ⸒⺆ㆇ↪㕙ߩ㓚ኂߩ৻ㇱߣߒߡᝒ߃ࠄࠇࠆߩߦᲧߒ
ߡ‫ޔ‬ญໃ࡮⥠࡮ჿᏪ߳ߩㆇേ๮઎ࠍมࠆㆇേ㊁߇଻ሽߐࠇߚฝඨ⃿៊்㧔RHD:
Right Hemisphere Damage㧕ߦࠃߞߡ↢ߓࠆࡊࡠ࠰࠺ࠖ↥↢㓚ኂߪᗵᖱ㓚ኂߣ㑐ㅪߠߌߡᝒ߃ࠄࠇࠆߎߣ߇ᄙ޿‫⎇ᧄޕ‬ⓥߢߪ‫↢↥ࠖ࠺࠰ࡠࡊޔ‬㓚ኂ߇⊹⾰࡮⊹⾰ਅ᭴ㅧࠍ฽߼ߚ⣖ౝࡀ࠶࠻ࡢ࡯ࠢߩ⎕✋ߦࠃߞߡ↢ߓࠆߣ઒⺑ࠍ┙ߡ‫ޔ‬1) RHD
ᖚ⠪ߦ߅ߌࠆࠬ࠻࡟ࠬ⽶⩄ታ㛎‫ޔ‬2) ஜᏱ⠪ 12 ฬࠍኻ⽎ߣߒߚࠬ࠻࡟ࠬ⽶⩄᧦ઙߦ߅ߌࠆ⊒⹤↥↢⺖㗴ࠍⴕߞߚ‫ߩࠬ࡟࠻ࠬޕ‬ᓇ㗀ᐲߩ⹏ଔߣߒߡ‫⤏⊹ޔ‬વዉᐲ㧔GSR: Galvanic Skin Response㧕‫ޔ‬⣂ᵄ߆ࠄᓧࠄࠇࠆᔃᜉᄌേ㧔HRV: Heart Rate
Variation㧕ࠍ⸘᷹ߒ㧔ታ㛎 1, 2㧕‫ޔ‬ታ㛎 2 ߦ߅޿ߡߪ HRV ࠃࠅ▚಴ߢ߈ࠆ੤ᗵ␹
⚻ᵴേᜰᮡ LF/(LF+HF)୯‫⊒⥄ޔ‬⣖ᵄࠃࠅᓟ㗡ㇱ㧔O1, O2㧕ߦ᦭ᗧߦ಴⃻ߔࠆǩ2ᚑಽࠍ᛽಴ߒߡ᳞߼ࠆၮᐙ⣖ᯏ⢻ᜰᢙ㧔FBA-index: Fundamental Brain Activity
index㧕ߦࠃࠆಽᨆ‫߮ࠃ߅ޔ‬㖸ჿߩ㖸㗀ಽᨆࠍⴕߞߚ‫ޕ‬ታ㛎ߩ⚿ᨐ‫ޔ‬ታ㛎 1 ߢߪࠬ࠻࡟ࠬ࠲ࠬࠢᤨߦ GSR ߩ਄᣹‫ޔ‬ᔃᜉᄌേߩᷫᒙ߇⹺߼ࠄࠇߚ‫ޕ‬ታ㛎 2 ߢߪ‫ޔ‬ࠬ࠻࡟ࠬ࠲ࠬࠢߦ߅޿ߡ GSR ୯߅ࠃ߮ LF/(LF+HF)୯߇਄᣹ߒ‫↢↥ࠖ࠺࠰ࡠࡊޔ‬㓚ኂ㧔ᛥ឴ߩᐔ᧼ൻ‫⇣ߩࡓ࠭࡝࡮࠻ࡦ࠮ࠢࠕޔ‬Ᏹ‫ޔ‬ή෻ᔕ㧕߇⊒↢ߒߚ‫ࠄߐޕ‬ߦ‫↢↥ࠖ࠺࠰ࡠࡊޔ‬㓚ኂ⊒↢₸ߩ㜞޿ኻ⽎⠪ߩ FBA-index ߪ቟㕒ᤨߦ߅޿ߡૐ
ߊ‫ߦᤨࠢࠬ࠲ࠬ࡟࠻ࠬޔ‬㜞ߊߥࠆ߽ߩߩᝄേߦਇ቟ቯߐ߇⹺߼ࠄࠇ‫ࠬ࡟࠻ࠬޔ‬ᛶ᛫ߩ⣀ᒙᕈߣ FBA-index ߩᓞേᕈ߅ࠃ߮ᒝᐲߣߩ㑐ㅪᕈ߇␜ໂߐࠇߚ‫ᧄޕ‬ታ㛎ߦ߅޿ߡ‫ޔ‬RHD ߢ߽ᖱേ෻ᔕߦᄌേ߇޽ࠆߎߣ߆ࠄᗵᖱ㧔ℂ⸃㧕ࠍ༚ᄬߒߡ
޿ߥ޿ߎߣ‫ޔ‬FBA ૐਅ߇↢ߓߚ⢛᥊ߣߒߡࡕࡁࠕࡒࡦࡃ࡜ࡦࠬߩ⎕✋߇㑐ଥߒߡ޿ࠆߎߣ߇ផኤߐࠇࠆ‫߁޿ߣ⹤⊒ߪ↢↥ࠖ࠺࠰ࡠࡊޕ‬㜞ᰴ⣖ᯏ⢻ߩ߭ߣߟߢ
޽ࠆ߇‫⸥ޔ‬ᙘ߿⥄Ꮖᗧ⼂ߥߤߩ㜞ᰴ߆ߟၮᧄ⊛ߥ⣖ᯏ⢻ࠍᜂ߁߽ߩߣߒߡ‫ޔ‬ㄭᐕ‫ࠢ࡯ࡢ࠻࠶ࡀ࠼࡯ࡕ࠻࡞ࠜࡈ࠺ޟ‬㧔DMN: Default Mode Network㧕‫߇ޠ‬ᵈ⋡ߐࠇߡ޿ࠆ‫ޕ‬DMN ߪ⥄⊒ᕈ⣖ᵄᵴേࠃࠅ᛽಴ߢ߈ࠆ⣖ౝ㗔ၞ㑆ߢߩᯏ⢻⊛⚿วߢ޽ࠆ‫ߦ↢↥ࠖ࠺࠰ࡠࡊޕ‬ଥࠆ⣖㗔㊁߇ DMN ࠍ᭴ᚑߔࠆ㗔㊁ߣ㊀ⶄߔࠆߎߣߪ㧘ࡊࡠ࠰࠺ࠖ↥↢㓚ኂ⊒↢߇ၮᧄ⊛ߥ⣖ᯏ⢻ࠍᡰ߃ࠆ⣖ౝࡀ࠶࠻ࡢ࡯ࠢ⚿วߩ⣀ᒙൻߦ⿠࿃ߔࠆߣ޿߁น⢻ᕈࠍ␜ໂߒߡ޿ࠆ߆߽⍮ࠇߥ޿‫ޕ‬੹ᓟߩዷᦸ⣖ᵄߣ fMRI ߣߩหᤨ⸘᷹ߦߡ⹦⚦ߥ⾮ᵴ࡮ਇᵴᕈㇱ૏ߩಽᨆ‫ ߮ࠃ߅ޔ‬PETߣߩหᤨ⸘᷹ߦࠃࠆ␹⚻↢ℂቇ⊛⸃ᨆࠍ↪޿‫ࠆߥࠄߐޔ‬ᬌ⸛ࠍㅴ߼ߡ޿ߊ‫ޕ‬－ 17 －

ࡇ࠶࠴ᦛ✢

䋨b䋩
䋨c䋩

䋨a䋩
⁜Ꮺၞ㩇㩗㩩㩂㩎㩥㩂㩨㩡㩛࿑㧚㖸ჿߩ㖸㗀ಽᨆ⚿ᨐ㧚ࠬ࠻࡟ࠬࠍฃߌࠆߎߣߢ‫ޔ‬ჿߩ㜞ߐᜰᮡߣߥࠆၮᧄ๟ᵄᢙ㧔F0㧕ߩ㜞ૐߩᐔ᧼ൻ㧔a㧕‫⇣ߩ࠻ࡦ࠮ࠢࠕޔ‬Ᏹ㧔b㧕‫ߩࠫࡦ࡟࠴࠶ࡇޔ‬᜛ᒛ߇↢ߓߚ㧔c㧕‫ޕ‬－ 18 －

⾈޿‛ⴕὑߩ੺⼔੍㒐ലᨐᎹේ㕏ᒄ 1, ੹੗⛗⟤ሶ 2,
1
 2

᩿␽㓷 2

᡼ㅍᄢቇ ජ⪲Ꮢ⟤ᵿ඙⧯⪲ 2-11
ᖱႎㅢା⎇ⓥᯏ᭴ ౓ᐶ⋵␹ᚭᏒ⷏඙ጤጟ↸ጤጟ 588-2

            email: kawahara@ouj.ac.jp
Keywords: ⣖ᵄ 㜞㦂⠪ ⾼⾈ ᦼᓙⷐᣦ⾈޿‛ߪ㧘㜞㦂⠪ߩ⥄Ꮖታ⃻ᚻᲑߩ৻ߟߢ޽ࠅ㧘⣖ᯏ⢻ߩᵴᕈൻߩ৻ഥߦߥ
ࠆน⢻ᕈ߇޽ࠆ㧚੺⼔ᣉ⸳߇ឭଏߔࠆ‫ߣޠ࡯ࠕ࠷‛޿⾈߅ޟ‬㗴ߒߚ⾈޿‛ߩડ↹࡮ઃ߈ᷝ޿ࠨ
࡯ࡆࠬߪ㧘ߚߣ߃߫㧘ᣣᏱ⊛ߦ⾈޿‛ࠍⴕࠊߥ޿㜞㦂⠪ߦ੺⼔⠪߇ઃ߈ᷝ޿㧘ࠬ࡯ࡄ࡯ࡑ࡯ࠤ࠶࠻ߥߤߢ 30 ಽ⒟ᐲ⾈޿‛ࠍⴕ޿㧘⾈޿‛ᓟߦ㜞㦂⠪ห჻ߢ⾼౉ຠࠍ⷗ߖว߁ߣ޿߁ࠗࡧࠚࡦ࠻ߣߒߡឭଏߐࠇࠆ㧚ᧄ⎇ⓥߩ⋡⊛ߪ㧘ߎߩ‫߅ޟ‬⾈޿‛࠷ࠕ࡯‫ߥ߁ࠃߩߤ߇ޠ‬ലᨐࠍ߽ߚࠄߔߩ߆㧘කቇ⊛ᩮ᜚ࠍ᣿ࠄ߆ߦߒߡ㧘᥉෸ߩߚ߼ߩၮ⋚ㅧࠅࠍߔࠆߎߣߢ޽ࠆ㧚ߘߩߚ߼ߦߪ㧘ലᨐߩቯ㊂ൻᚻᴺߩ⠨᩺߇ᔅⷐߦߥࠆ㧚 ᧄ⎇ⓥߢߪ㧘⾼⾈ⴕὑߦ߅ߌࠆᦼᓙᗵ߇ࡕࡁࠕࡒࡦ␹⚻ᵴേࠍ⾮ᵴߔࠆߣ޿
߁㧘઒⺑ࠍߚߡߚ㧚઒⺑ࠍታ⸽ߔࠆߚ߼ߩᣇᴺߣߒߡ㧘㗡⊹਄⥄⊒⣖ᵄ߆ࠄၮᐙ⣖ߩࡕࡁࠕࡒࡦ␹⚻ᵴേࠍ⹏ଔߔࠆᣇᴺࠍታᣉߒ㧘⾈޿‛ߦࠃࠆࡕࡁࠕࡒࡦ
␹⚻♽ߩ⾮ᵴࠍࡕ࠾࠲࡝ࡦࠣߔࠆߚ߼ߩᚻᴺߩ᦭ലᕈߦߟ޿ߡᬌ⸛ߒߚ㧚 ⾈޿‛࠷ࠕ࡯ᓟߩ⥝ᅗߦࠃࠆ੤ᗵ␹⚻ᵴേߩᛥ೙߽⠨ᘦߦ౉ࠇ㧘࿑㧝ߩࠃ߁ߥ߅⾈޿‛ࡊࡠࠣ࡜ࡓࠍឭ᩺ߒ㧘⣖ᯏ⢻ᵴᕈߣ੤ᗵ␹⚻ᵴേᛥ೙ߩലᨐ᷹ቯߦ
ߟ޿ߡᬌ⸛ߒߚ㧚੹ᓟߩዷᦸ
⾼⾈ⴕὑߢᓧࠆߎߣߩߢ߈ࠆⶄᢙߩೝỗ㧔․ቯߩㆇേ㧘੖ᗵೝỗ㧘ᦼᓙᗵߥߤߩᗵⷡ㧕ߩ߁ߜ㧘ߤߩೝỗ߇ࡕࡁࠕࡒࡦ␹⚻ᵴേߩ⾮ᵴߦነਈߒߡ޿ࠆߩ߆
᣿ࠄ߆ߦߔࠆ㧚ࡕࡁࠕࡒࡦ␹⚻♽ߩ⾮ᵴࠍࡕ࠾࠲࡝ࡦࠣߔࠆߚ߼ߩᚻᴺߩ᦭ല
ᕈߦߟ޿ߡߐࠄߦᬌ⸛ߔࠆ㧚－ 19 －• ᦼᓙ• ㆇേ⸠✵

⒖േ

• ㆇേ
• ᦼᓙ

• ᗧᕁ᳿ቯ
• ੖ᗵೝỗ

䈍⾈䈇‛䈱ᣣ
䉁䈪䈱↢ᵴ

⾈䈇‛

ળ⹤

• ḩ⿷
• 䉮䊚䊠䊆䉬䊷䉲䊢䊮⣖ᵴᕈ

࿑ 1 ߅⾈޿‛࠷ࠕ࡯ࡊࡠࠣ࡜ࡓ

－ 20 －• 䊥䊤䉾䉪䉴• ๭ๆ䉝䊐䉺䊷䉬䉝

੤ᗵ␹⚻ᵴേ䈱ᛥ೙ⷡ㉕⊛൬޿ೝỗߦࠃࠆ㒰∩ലᨐဌ၂෹⟤ 1,᩿␽㓷 2, Ꮉේ㕏ᒄ 3, ቝ૒⟤⋿ 4㪈ᗲ⍮ක⑼ᄢቇ㩷 ⋴⼔ቇㇱ㧘ᗲ⍮⋵㐳ਭᚻᏒጤ૞㓵෶ 㪈 ⇟࿾䋱⁛㪀㩷 ᖱႎㅢା⎇ⓥᯏ᭴㩷 ⣖ᖱႎㅢାⲢว⎇ⓥᚲ䋬౓ᐶ⋵␹ᚭᏒ⷏඙ጤጟ↸ጤጟ 㪌㪏㪏㪄㪉㩷㪊᡼ㅍᄢቇᄢቇ㒮 ᢥൻ⑼ቇ⎇ⓥ䋬ජ⪲Ꮢ⟤ᵿ඙⧯⪲ 㩷㪋␹ᚭᄢቇᄢቇ㒮㩷 ଻ஜቇ⎇ⓥ⑼䋬౓ᐶ⋵␹ᚭᏒ㗇⏴඙෹䈏ਐ 㪎㪄㪈㪇㪄㪉㩷㪉               email: bohgaki@aichi-med-u.ac.jp
Keywords: ൬޿ ⷡ㉕࡮㎾㕒ࠕࡠࡑ 㒰∩ ␹⚻↢ℂ

ⷐᣦࠊ߇࿖ߩᘟᕈ−∩଻᦭⠪ߪჇടߩ৻ㅜߢ޽ࠅ‫ޔ‬ᖚ⠪ߩ7ഀߪᴦ≮ߦࠃߞߡ∩ߺߪ✭๺ߐࠇߡ޿ߥ޿㧔᦯ㇱ‫ޔ‬2006㧕‫ޔ‬ㆡಾߥ−∩ߩᴦ≮߿▤ℂ߇᳞߼ࠄࠇߡ޿ࠆ‫ޕ‬⧐㚅ᕈើ⊒ᕈ᦭ᯏൻว‛ߢ޽ࠆࠕࡠࡑ㧔൬޿㧕ߪ‫ޔ‬−∩ࠍ⹺⍮ߔࠆ⣖ᯏ⢻ో૕ߦ૞↪ߒ‫ޔ‬ൻቇ⵾೷ࠍ↪޿ࠆㅢᏱක≮ࠍ⵬ቢ࡮ઍᦧߔࠆ⿥ૐଚⷅߩ−∩೙ᓮᴺ
ࠍ⏕┙ߔࠆ਄ߢ᦭↪ߣᕁࠊࠇࠆ‫⎇ᧄޕ‬ⓥߢߪ‫ޔ‬30บஜᏱ↵ᕈࠍኻ⽎ߦ‫⊛㉕ⷡޔ‬൬޿㧔ࡠ࡯࠭ࡑ࡝࡯ࠞࡦࡈࠔ࡯ߥߤ㧕ߣ㎾㕒⊛൬޿㧔ࡊ࠴ࠣ࡟ࡦߥߤ㧕ߦߟ޿ߡ‫ޔ‬Aį✢⛽ࠍೝỗߔࠆኙ಄᣹࿶⹜㛎ࠍ↪޿ߡ∩ߺࠍ⺃⊒ߒ‫ޔ‬⣖ᵄ‫ޔ‬ᔃᜉᄌേ‫ޔ‬๭ๆ‫ޔ‬ਥⷰ⊛−∩⹏ଔ㧔VAS㧕߆ࠄ㒰∩ലᨐࠍᲧセߔࠆ੍஻ታ㛎ࠍⴕߞߚ‫ޕ‬
ⷡ㉕⊛ࠕࡠࡑߢߪ‫ޔ‬Į ᵄߩ㜞޿๟ᵄᢙᏪၞ㧔Į2㧕߇ఝ૏ߦ಴⃻ߒ‫ࡦࡒࠕࡁࡕޔ‬␹⚻ߩᵴᕈߣ⋧㑐߇޽ࠆၮᐙ⣖ᵴᕈᜰᢙ㧦Fundamental Brain Activity (FBI) indexߩ਄᣹ߣ౒ߦ VAS ୯ࠍૐᷫߒߚ㧔࿑ 1㧕‫ޕ‬HRV ߩࠬࡍࠢ࠻࡞⸃ᨆߢߪ‫⊛㉕ⷡޔ‬൬޿ߢ੤ᗵ␹⚻ఝ૏‫ޔ‬ᔃᜉߣ๭ๆߩ Coherence ߢߪⷡ㉕⊛൬޿ߢભᕷᤨߣห⒟ᐲߩ
ή⋧㑐߽ߒߊߪ⧯ᐓߩᱜߩ⋧㑐ࠍ␜ߒߚ(࿑ 2)‫⎇ᧄޕ‬ⓥߢⷡ㉕⊛൬޿ߪ‫ޔ‬༦ⷡࠍ੺ߒߡ‫ޔ‬ၮᐙ⣖ࠍᵴᕈൻ̆࠼࡯ࡄࡒࡦ̆࠮ࡠ࠻࠾ࡦߩ⋧㑐ᵴേࠍᵴ⊒ൻߔࠆߎߣߦࠃࠆ−∩೙ᓮലᨐ߇޽ࠆߎߣ߇ផ᷹ߢ߈ߚ‫ޕ‬ᧄ⎇ⓥߩ৻ㇱߪ⑼ቇᛛⴚᝄ⥝ᯏ᭴ ,56%4'56‫ޔ‬෸߮ቇⴚ⎇ⓥഥᚑၮ㊄ഥᚑ㊄㧔ၮ⋚ % ߩ⵬ഥࠍฃߌታᣉߒߚ‫ޕ‬੹ᓟߩዷᦸ੹ᓟߪ൬޿ߩ㒰∩ᯏ᭴ߩࡕ࠺࡝ࡦࠣߩ᭴▽ߦะߌߡߐࠄߦၮ␆⎇ⓥࠍㅴ߼ߡ޿ߊ‫ޕ‬－ 21 －

8#5                         

಄᳓ೝỗ

಄᳓ೝỗ

FBA index㪈㪉

Aroma2䋨ⷡ㉕♽䋩ᙾᣧኒ ᵟᶐᶍᶋᵿ

Aroma1(✭๺♽䋩ᦒ᩺ኒ ᵟᶐᶍᶋᵿ

㪏

㪋

㪇
㪇

㪉㪇㪇

㪋㪇㪇

㪍㪇㪇

㪏㪇㪇

㪈㪇㪇㪇

㪈㪉㪇㪇

Time (s)㪈㪋㪇㪇࿑㪈㩷 ኙ಄ೝỗ⹜㛎䈮䈍䈔䉎ਥⷰ⊛−∩⹏ଔ䈫ၮᐙ⣖ᵴᕈᜰᢙ䈱ផ⒖㩷

࿑㪉㩷 ኙ಄ೝỗ⹜㛎䈮䉋䉎ᔃᜉ䈫๭ๆ䈱㪚㫆㪿㪼㫉㪼㫅㪺㪼㩷 㩷－ 22 －

cPA ߦࠃࠆᶏ㚍ߩㆃ⊒ᕈ␹⚻⚦⢩ᱫᛥ೙ലᨐ૞↪ߩಽሶᯏ᭴ߩ⸃᣿
೨↰᩵ 1, ᓟ⮮⌀㉿ 2 , ၳ↰᥍⟤ 3, ቶફᡌ 1, ቶફ߈ߺሶ 11߅⨥ߩ᳓ᅚሶᄢቇᄢቇ㒮 ੱ㑆ᢥൻഃᚑ⑼ቇ⎇ⓥ⑼
‫ޥ‬112-8610 ᧲੩ㇺᢥ੩඙ᄢႦ 2-1-12߅⨥ߩ᳓ᅚሶᄢቇ ↢๮ᖱႎቇᢎ⢒࠮ࡦ࠲࡯3᧲੩ㇺஜᐽ㐳ኼක≮࠮ࡦ࠲࡯⎇ⓥᚲ
‫ޥ‬173-0015 ᧲੩ㇺ᧼ᯅ඙ᩕ↸ 35-2
email:murofushi.kimiko@ocha.ac.jp
Keywords: Ⅳ⁁ࡎࠬࡈࠔ࠴ࠫࡦ㉄ ㆃ⊒ᕈ␹⚻⚦⢩ᱫ ࠕࡐ࠻࡯ࠪࠬᛥ೙

ⷐᣦ␹⚻⚦⢩ߦ߅޿ߡ‫ޔ‬Ⅳ⁁ࡎࠬࡈࠔ࠴ࠫࡦ㉄(cyclic phosphatidic acid: cPA)ߪ‫ޔ‬invitro ߢᶏ㚍ߩ␹⚻⚦⢩ߦኻߒߡ⚦⢩Ⴧᱺ࡮ಽൻࠍଦㅴߔࠆ Neuro Growth factor(NGF)᭽ߩ௛߈ࠍᜬߟߎߣ߇᣿ࠄ߆ߦߥߞߡ޿ࠆ‫ ߚ߹ޕ‬in vivo ߢߪ‫৻ޔ‬ㆊᕈ⣖⯯
ⴊಣℂࠍᣉߒߚ࡜࠶࠻ߦ cPA ࠍᛩਈߒߚ႐ว‫ޔ‬⣖⯯ⴊߦࠃࠅᒁ߈⿠ߎߐࠇࠆᶏ
㚍ߩㆃ⊒ᕈ␹⚻⚦⢩ᱫ߇ᛥ೙ߐࠇࠆߎߣ߇⷗಴ߐࠇߚ‫ޔߒ߆ߒޕ‬cPA ߩ␹⚻⚦⢩ᱫߩᛥ೙ലᨐߦ㑐ߔࠆಽሶᯏ᭴ߦߟ޿ߡߪᧂߛ᣿ࠄ߆ߦߥߞߡ޿ߥ޿‫ޕ‬ߘߎߢ‫⎇ᧄޔ‬ⓥߢߪ‫ޔߡߞࠃߦࡓ࠭࠾ࠞࡔߥ߁ࠃߩߤޔ‬cPA ߇ㆃ⊒ᕈ⚦⢩ᱫࠍᛥ೙ߔࠆߩ߆ࠍ⸃᣿ߔࠆߎߣࠍᦨ⚳⋡⊛ߣߒ‫⚦⚻␹ޔ‬⢩ߩࠕࡐ࠻࡯ࠪࠬߦ߅ߌ
ࠆ cPA ߩᛥ೙ലᨐࠍᬌ⸛ߒߚ‫ޕ‬    ੹ᓟߩዷᦸᧄ⎇ⓥߦ߅޿ߡ‫ޔ‬Neuro2A ⚦⢩ߢߪႮൻࠦࡃ࡞࠻ೝỗߦࠃߞߡ⺃ዉߐࠇࠆࠕ
ࡐ࠻࡯ࠪࠬ߇ cPA ᷝടߦࠃߞߡᛥ೙ߐࠇࠆߎߣ߇᣿ࠄ߆ߦߥߞߚ‫࠻ࡐࠕߩߎޕ‬࡯ࠪࠬᛥ೙ലᨐߪ LPA ᷝടߦࠃߞߡ߽ⷰኤߐࠇߚ‫ޔߒ߆ߒޕ‬LPA ࡟࠮ࡊ࠲࡯ߩ
㒖ኂ೷ߢ޽ࠆ Ki16425 ߩᷝടߦࠃࠅ‫ޔ‬LPA ߩ㒖ኂലᨐߪᒙ߹ߞߚߩߦኻߒ‫ޔ‬cPAߩ㒖ኂലᨐߦߪᄌൻ߇⷗ࠄࠇߥ߆ߞߚߎߣ߆ࠄ‫ޔ‬ਔ⠪ߪ⇣ߥࠆ⚻〝ࠍ੺ߒߡࠕ
ࡐ࠻࡯ࠪࠬࠍᛥ೙ߒߡ޿ࠆߎߣ߇␜ໂߐࠇߚ‫ޕ‬੹ᓟߪࠕࡐ࠻࡯ࠪࠬᛥ೙ߩࠪࠣ࠽࡞વ㆐♽ࠍ⸃᣿ߔࠆߎߣࠍ⋡ᜰߒ⎇ⓥࠍㅴ
߼ߡ޿ߊ‫ޕ‬－ 23 －

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