RESEARCH NEWS STORY
July 20, 2023
Chiba University

New Study Expands the Scope ofAza-Friedel−Crafts Reactions

A novel bulky PyBidine-Ni(OAc)2 catalyst enables the substitution of imines to the paraposition of phenol rings
Selective addition of substituents to specific positions in organic compounds has been
instrumental in producing a wide range of products. In a groundbreaking study, scientists
from Chiba University, Japan, introduced a novel catalyst called bulky PyBidine-Ni(OAc)2 forthe aza-Friedel−Crafts reaction of phenols with imines. The catalyst preferably generates
para-substituted products instead of conventional ortho-substituted products,
considerably expanding the possibilities for synthesizing novel compounds.

Image Title: Switching the regioselectivity from ortho- to para-selectivity in the aza-Friedel−Crafts reaction.
Image Caption: An innovative bulky PyBidine-Ni(OAc)2 catalyst developed by Chiba University researchers
expands the scope of aza-Friedel−Crafts reactions by favoring the production of para-substituted products
over the conventional ortho-substituted products, opening new possibilities for generating a wide variety ofnovel compounds.
Image Credit: ACS CatalysisImage Link: https://pubs.acs.org/doi/10.1021/acscatal.3c01961
License Type: CC BY 4.0

From life-saving drugs and synthetic polymers to diverse advanced materials, the products
containing organic compounds seem endless, thanks in part to regioselectivity, a feature inchemical reactions where a substituent is selectively added to a specific position of an organiccompound. This favors the formation of desired products with specific functionalities. One
notable regioselective reaction used for the precise design of organic compounds is theFriedel−Crafts reaction, which enables the addition of substituents to specific positions onaromatic compounds such as benzene and phenol rings.
In the traditional acid-catalyzed aza-Friedel−Crafts reaction of phenols with imines, thesubstitution reaction typically occurs adjacent to the hydroxy (–OH) group of the phenol ring.
This leads to the formation of ortho-products such as α-aminobenzylphenols, which holdsignificant importance in the production of agrochemicals and pharmaceuticals. However,achieving selective substitution at the para-position further away from –OH is challenging andhas only been observed for a few substrates.
In a new study published in the journal ACS Catalysis on July 03, 2023, Professor Takayoshi
Arai from the Graduate School of Science at Chiba University in Japan, along with Masters'students, Mr. Ryoya Tajima and Mr. Takaaki Saito, has made a significant breakthrough bydeveloping a general para-selective aza-Friedel−Crafts type reaction of phenols with imines.
Their work has opened up new possibilities for the rapid and safe synthesis of medicines andadvanced materials. “There has been no general way to achieve a para-selective azaFriedel−Crafts reaction of phenols until now,” says Prof. Arai, highlighting the novelty of thepresent work.
In the traditional aza-Friedel−Crafts reaction, ortho-products are formed in the presence of aLewis acid catalyst. The challenge faced by the researchers was to steer the reaction towards
favoring para-substituted products. To solve this issue, they took inspiration from their earlier
experiments, in which they had observed that the bis(imidazolidine) pyridine (PyBidine)metal complex platform had the potential to carry out the aza-Friedel−Crafts reaction ofphenols with imines due to its ability to function both as an acid and a basic catalyst.
In a series of tests, the researchers found in their present work that the PyBidine-Ni(OAc)2complex showed a preference for para-substituted products. They then replaced the benzyl
substituent of PyBidine with a bulky diphenylethyl group to obtain a “bulky PyBidine”Ni(OAc)2 catalyst, which facilitated highly para-selective aza-Friedel-Crafts reactions with up
to 99:1 para/ortho selectivity. Furthermore, 3,5-dialkoxyphenols with various
sulfonylaldimines yielded para-substituted products—with up to 93% enantiomeric excess(chiral purity)—in the presence of a Sr(OAc)2 additive.
By employing DFT calculations, the researchers found that this regioselectivity was due to acooperative activation of the highest occupied molecular orbital (HOMO) of 3,5dialkoxyphenols and the lowest unoccupied molecular orbital (LUMO) of sulfonylaldimines.
The reaction began with the formation of a nickel phenoxide, which enhanced the reactivity
at the para-position of the phenol group in a process called HOMO activation. The
sulfonylaldimine was then attached to this position via hydrogen bonds on the bulky PyBidineNi(OAc)2 catalyst through LUMO activation, resulting in the formation of the final product.

This HOMO–LUMO activation was the key to switching the regioselectivity for the design anddevelopment of functional molecules for medicines, agrochemicals, and other materials.
In effect, this study is a significant step in the field of regioselective reactions for futureapplications in various industries. “The rapid and safe synthesis method has improved thesynthetic efficiency of an orexin antagonist and is expected to contribute to an
environmentally benign and sustainable chemistry,” concludes a hopeful Prof. Arai.

About Professor Takayoshi Arai
Dr. Takayoshi Arai is a Professor at the Department of Chemistry at the Graduate School ofSciences at Chiba University. His research focuses on the development of new compounds
and catalysts with specific functionalities and novel synthesis of known organic compounds
for various applications, contributing to the advancements in catalysis and enantioselectivesynthesis. He has published around 170 research articles, which have been cited nearly 10,000
times.
Reference
Title of original paper: Asymmetric para-Selective aza-Friedel−Crafts Reaction of Phenols
Catalyzed by Bulky PyBidine-Ni(OAc)2Authors: Ryoya Tajima, Takaaki Saito, and Takayoshi Arai
Affiliation(s): Soft Molecular Activation Research Center (SMARC), Chiba Iodine Resource
Innovation Center (CIRIC), Synthetic Organic Chemistry, Department of Chemistry, Graduate
School of Science, Chiba University
Journal: ACS Catalysis
DOI: 10.1021/acscatal.3c01961
Contact:
Takayoshi ARAI
Graduate School of Science, Chiba University
Address: 1-33 Yayoi, Inage, Chiba 263-8522 JAPAN
Email: tarai@faculty.chiba-u.jp
Public Relations Office, Chiba University
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