HEALTH - FOOD

THE LIFE GUARDIAN™

MERIVA®

CURCUMIN PHYTOSOME

These statements have not been evaluated by the Food and Drug Administration. This product is not intended todiagnose, treat, cure, or prevent any disease.

Please note that the physiological activity of the ingredient described herein is supported by the referenced
clinical trial reports. Marketers of finished products containing the ingredient described herein are responsible fordetermining whether the claims made for such products are lawful and in compliance with the laws of the country
in which they will market the products.WHAT MAKES MERIVA® UNIQUE?

MERIVA® is a patent pending delivery
form of curcumin. Curcumin typicallyexhibits poor oral absorption in the body.1
Pharmacokinetic comparison studies haveshown MERIVA® to improve bioavailabilityof curcuminoids by about 30-fold.2,3Threestudies
conductedwithMERIVA®
demonstrated
significant
improvements related to stiffness,muscle soreness, physical function,
liver health and overall quality of life.
A long term study has shown MERIVA®
to support ocular health,6,8 confirming
the inflammatory response markers
support and the excellent safety profile.

MERIVA® is the 100% natural food grade delivery form ofcurcumin utilizing Indena proprietary Phytosome technology,
based on dietary-grade adjuvants (lecithin), able to optimize
the bioabsorption of the extract.

TRADEMARKSMERIVA® is a trademark of Indena S.p.A. andits logo and usage guidelines are available
from Indena.
References
1
Anand, P. et al., Mol. Pharmaceutics: 2007, 4(6), pp. 807-818.
2
Cuomo J. et al., J Nat Prod. 2011 Mar 17.
3
Marczylo T.H. et al., Cancer Chemother. Pharmacol. 2007, 60 (2), 171-7.
4Belcaro G. et al.., Panminerva Medica 2010, 52 (2 Suppl 1), 55-62.
5Belcaro G. et al.., Altern Med Rev. 2010,15(4):337-44.
6Allegri P. et al., Clinical Ophtalmology 2010, 4, 1201-1206.
7Appendino G. et al., Panminerva Medica 2011, 53 (3 Suppl 1):43-9
8Steigerwalt R. et al., Panminerva Med. 2012 54 (Suppl. 1 to No. 4): 11-6
9Drobnic F. et al., J Int Soc Sports Nutr. 2014 Jun 18;11:31
10Sciberras JN. et al, J Int Soc Sports Nutr. 2015 Jan 21;12(1):511Franceschi F. et al., Eur Rev Med Pharmacol Sci 2016; 20(4):762-6
12Dugall M. et al., Eur Rev Med Pharmacol Sci 2017; 21 1684-913
Panahi Y. et al., J Cardiovasc Pharmacol 2016 Sep 68(3): 223-9
14
Panahi Y. et al., Drug Res (Stuttg) 2017 Apr: 67(4): 244-251
15
Gianni Belcaro et al., Panminerva medica 2019 december;61(4):444-8
16Pivari, F. et al., Nutrients 2022, 14, 231. https://doi.org/10.3390/nu14010231*Contact Indena directly for the latest available studies• Healthy blood vessel function support.7• Attenuated muscle soreness from oxidative stressand inflammation associated to continuous exercise;9,10• Improved strenght and physical performance,
preventing loss of lean body mass in elderly
population;11• Improved bone density in asymptomaticsubjects with a bone density condition12• Improved health status in subjects with
non-alcoholic fatty liver disease (NAFLD).13,14
Two recent studies highlighted MERIVA® efficacy insupporting kidney health:• The University of Chieti-Pescara evaluated thesupplementation of MERIVA® in subjects withtemporary kidney dysfunction (TKd) and increasedoxidative stress levels. The clinical evidence showedthat albuminuria decreased in all subjects due to its
antioxidant properties and oxidative stress level was
positively affected after 4 weeks;15• The University of Milan, focused its study on chronic
kidney disease (CKD) subjects: MERIVA® significantly
levelled plasma pro-inflammatory mediators and lipidperoxidation.
Regarding gut microbiota, after 6 months of curcumin
supplementation it was observed a more balanced
composition of the intestinal microbial population.16

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trademarks of Indena S.p.A. © 2022, Indena S.p.A.

SCIENTIFIC EVIDENCEMERIVA® is overall supported by morethan 30 human studies, involving 2000+individuals, confirming its high tolerability
profile.

MERIVA® is supported by more than 35* human trials
demonstrating effective support in multiple health conditions:• Decreased WOMAC score measuring excercise
related pain, stiffness and physical function;4-5• Social and Emotional Index (SEI) score resulted in agreater than 3-fold improvement;4• C-Reactive Protein (CRP) levels: minus 16-fold;4,RECOMMENDED DOSEMERIVA® is a light yellow powder for use innutritional supplements.
Recommended daily dose: 1 gMERIVA® pharmacokinetic studies demonstrated
significant absorption benefits:2,3• Improved plasma Cmax and AUC of curcuminoids near30-fold over the standard turmeric extracts.

® TM

SPECIFICATIONSMERIVA® is standardized to contain
18-22% of total curcuminoids.

MERIVA® is the most studied and documented curcuminbioavailable formulation.

DPR0183 - 02/2012*04/2022

WHAT IS MERIVA®?