Sugahara Memorial International Symposium

Prospective Topics and Charm ofRadiation Biology
Radiation biology is an important key to solve biological system

Professor Tsutomu Sugahara(Feb 6, 1921~Oct 1, 2010)

Date:
January 25-26, 2012
Place:
Shiran-kaikan Inamori Hall, Kyoto University,Kyoto, Japan
Organizers:
Morgan WF (PNNL,USA)
Matsumoto T (Kyoto University, Japan)
Watanabe M (Kyoto University, Japan)
Sponsorship:
Kyoto University
The Japan Health Foundation
Cosponsorship:
The Nuclear Safety Commission of JapanThe Japan Radiation Research Society
Health Research Foundation
Registration: mail to "msm@rri.kyoto-u.ac.jp"
Registration fee: FreeLanguage: English

Aim of symposium：
The radia1on biology may become the key to un1e a mechanism of all biologicalresponses. However, it does not actually become an a>rac1ve research ﬁeld forthe young scien1sts at the present. A@er Fukushima nuclear plant accident,
radia1on biology may a>ract a special a>en1on as the research ﬁeld ofradioprotec1on. However, the excessive development as an applica1on study ﬁeld
has risk of disturbing the evolu1on of fundamental sciences.
Dr. Sugahara worried about this during the all life1me. Therefore, we are planningto hold the Sugahara Memorial Interna1onal Symposium 1tled on “Prospec1ve
Topics and Charm of Radia1on Biology” this 1me. And, we ask speakers to talkabout a prospec1ve topic and charm of radia1on biology to the young researcher.
We wish that this symposium becomes the driving force of the biological eﬀect
study of the low dose radia1on and the young researchers who are interested inradia1on biology increase.

Program
Jan25
Morning session (10:30-12:00)
Opening remarks
Aim of symposium
Pictorial history of Professor Sugahara
My memory of Dr. Sugahara as a scientist and friend

Toritsuka K (The Japan Health Foundation)
Watanabe M (kyoto University)
Utsumi H (Health Research Foundation)
Song CW (University of Minnesota)

Afternoon Session (13:00-17:45)
Session(1) Biological effects of low dose radiation
1.Cherishing the memory of Dr Sugahara, carrying on theChinese radiation epidemiological studies
2.Radio adaptive response induced by low dose-rate
3.Biological effects of low-dose radiation assessed by asensitive assay system
4.Biological effects of low dose radiation

Quanfu S (NIRPNS, China)Tachibana A (Ibaragi University)
Tauchi H (Ibaragi University)
Kim E-H (Seoul National University, Korea)

Session(2) Molecular mechanism
5.Dose rate effect: A principal cellular response to ionizingradiation
6.The roles of NBS1 in responses to radiation- and UVinduced DNA damage
7.Fanconi anemia and the DNA damage response

Suzuki F (Hiroshima University)
Komatsu K (Kyoto University)
Takaka M (Kyoto University)

Session(3) Genetical instability
8.Non-targeted effects of radiation exposure: recent
advances in the field
9.Radiation-induced genomic instability in Medaka fish
10.Stress response controlled by differential binding of p31
comet to p53

Kadhim M (University of Oxford, UK)
Todo T (Osaka University)
Matsumoto T (Kyoto University)

Jan26
Morning Session (9:00-12:45)
Session(4) Radicals
11.Exploiting X-ray-inducible proteins for cancer radiotherapy
12.Optimization of intracellular reactive oxygen species levels
by antioxidant proteins in vertebrate cells
13.Modulation of radiation responses by mitochondria-targeted
SOD2 and gltaredoxin 2 in human cells
14.Mutagenic long-lived radicals in mammalian cells induced byionizing radiation and bystander effects

Boothman DA (University of Texas, USA)
Tano K (Kyoto University)
Akiyama S (Kyoto University)
Kumagai (Nagoya University)

Session(5) Bystander effect
15.Studies of bystander responses at low dose and withmodulated beams
16.Mitochondrial modulation in radiation induced bystander effect
17.The evidence that low dose radiation involves non-targetedeffects
18.DNA double strand breaks in CHO-K1 and xrs-5 cells
irradiated with mixed neutron and gamma-rays for BNCT

Prise KM (Queens University, UK)
Kashino G (Oita University)
Matsumoto H (Fukui University)
Takahashi S (Kyoto University)

Afternoon Session (13:40-18:05)
Session(6) Carcinogenesis and aging
19.Origin of radiation transformation is non-DNA damage
20.Radiation-induced carcinogenesis of the mammary gland
21.Mining the lifespan studies of Beagle dogs exposed to ionizing
radiation
22.Stereoinversion of aspartyl residues occur widely in proteinsfrom the living tissues of elderly donors

Watanabe M (Kyoto University)
Imaoka T (NRRL)
Morgan WF (PNNL, USA)
Fujii N (Kyoto University)

Session(7) Stem cell23.Integrated system approach to study radiation induced
signaling in a 3D human skin model
24.Molecular mechanism of radiation-induced thyroid cancer
25.Radiation response of mouse neural stem cells
26.Mechanism of radiation-induced mammary carcinogenesis

Summary
Closing remarks

Sowa MB (PNNL, USA)
Suzuki K (Nagasaki University)
Kodama S (Osaka Prefecture University)
Hei TK (Columbia University, USA)
Suzuki K (Nagasaki University)
Imaoka T (NRRL)
Morgan WF (PNNL, USA)

Program of the Sugahara Memorial International Symposium on" Prospective Topics and Charm of Radiation Biology"
Radiation biology is an important key to solve biological system

in Kyoto, January 25-26, 2012.
Organizers: Morgan WF (Pacific North National Laboratory, USA), Matumoto H (Radiation Biology Center, Kyoto University, Japan),
Watanabe M (Radiation Life Science, Kyoto Univesrity, Japan)
Sponsorship: The Japan Health Fundation, Kyoto University
Cosponsorship: The Nuclear Safety Committion of Japan, The Japan Radiation Research Society, Health Research Foundation
Registaration: email or fax your name, organization and e-mail address to M Watanabe (e-mail address: msm@rri.kyoto-u.ac.jp,Fax:072-451-2628)

Date / Timestart end

Title of lecture

Speakers

Organization

25.Jan9:30 10:30 Registration
10:30 10:35 Opening Remarks

Toritsuka K

10:35 10:40 Aim of Symposium
10:40 11:10 Special Lecture (1) Pictorial history of Professor Sugahara

Watanabe M
Utsumi H

10:10 11:50 Special Lecture (2) My memory of Dr.Sugahara as a scientistand friend

Song CW

President of the Japan HealthFoundation
Professor of Kyoto University
Principal Scientist of HealthResearch Foundation
Professor of University ofMinnesota, USA

12:00 13:00 Lunch BreakSession (1) Biological effects of low dose radiation
13:00 13:30 Lecture (1)13:30 13:55 Lecture (2)13:55 14:20 Lecture (3)14:20 14:50 Lecture (4)Chair Persons：Drs Kadhim M and Matsumoto T

Cherishing the memory of Dr. Tsutomu
Sugahara, carrying on the Chinese radiation
epidemiological studies
Radioaptive response induced by low dose-rateirradiation
Biological effects of low-dose radiation assessedby a sensitive assay system
Biological Effect of Low Dose Radiation

Quanfu S

Tachibana A

National Institute forRadiological Protection andNuclear Safety, China
Ibaragi University

Tauchi H

Ibaragi University

Kim E-H

Seoul National University,Korea

14:50 15:10 Coffee BreakSession (2) Molecular response
15:10 15:35 Lecture (5)15:35 16:00 Lecture (6)16:00 16:25 Lecture (7)Dose-rate effect: a principal cellular response to Suzuki F
ionizing radiation
The roles of NBS1 in responses to radiation- and Komatsu K
UV-induced DNA damage
Fanconi anemia and the DNA damage response Takata M

Section(3) Genetical effects
16:25 16:55 Lecture (8)Chair persons：Drs Sowa MB and Takata M
Hiroshima University
Kyoto university
Kyoto University

Chair Persons：Drs Quanfu S and Komatsu K

Non-targeted effects of radiation exposure: recent Kadhim M
advances in the field
Lecture (9) Radiation-induced genomic instability in Medaka Todo T
16:55 17:20
fish
17:20 17:45 Lecture (10) Stress response controlled by differential binding Matsumoto Tof p31comet to p53

University of Oxford, UKOsaka University
Kyoto University

26.JanSession (4) Induced radicals and proteins

Chair persons：Drs Fujii N and Morgan WF

9:00 9:30 Lecture (11) Exploiting x-ray-inducible proteins for cancer
Boothman DA University of Texas, USAradiotherapy
9:30 9:55 Lecture (12) Optimization of intracellular reactive oxygen
Tano K
Kyoto University, Kumaori
species levels by antioxidant proteins invertebrate cells
9:55 10:20 Lecture (13) Modulation of radiation responses byAkiyama S
Kyoto University, Kyoto
mitochondria-targeted SOD2 and glutaredoxin 2in human cells
10:20 10:45 Lecture (14) Mutagenic long-lived radicals in mammalian
Kumagai J
Nagoya University, Nagoya
cells induced by ionizing radiation and bystandereffects
10:45 11:00 Coffee break
Session(5) Bystander effect
Chair persons：Drs Kim E-H and Boothman DA
11:00 11:30 Lecture (15) Studies of bystander responses at low dose and Prise KM
Queens University Belfast,
UKwith modulated beams
11:30 11:55 Lecture (16) Mitochondrial modulation in radiation induced Kashino G
Oita University, Oita
bystander effect
11:55 12:20 Lecture (17) The evidence that low dose radiation involves
Matsumoto H Fukui University, Fukui
non-targeted effects in targeted effects
12:20 12:45 Lecture (18) DNA double strand breaks in CHO-K1 and xrs-5 Takahashi S
Kyoto University, Kumatori
cells irradiated with mixed neutron and gammarays for BNCT
12:45 13:40 Lunch BreakSection(6) Carcinogenesis and aging
Chair persons：Drs Kakinuma S and Hei T
13:40 14:05 Lecture (19) Origin of radiation transformation is non-DNA Watanabe M Kyoto University, Kumatori
damage14:05 14:30 Lecture (20) Radiation-induced carcinogenesis of theImaoka T
NRRL, Chiba
mammary gland
14:30 15:00 Lecture (21) Mining the Lifespan Studies of Beagle Dogs
Morgan WF
PNNL, USA
Exposed to Ionizing Radiation
15:00 15:25 Lecture (22) Stereoinversion of aspartyl residues occur widely Fujii N
Kyoto University, Kumatoriin proteins from the living tissues of elderly
donors
15:25 15:45 Coffee break
Section(7) Stem cell

Chair persons：Drs Akiyama S and Prise KM

15:45 16:15 Lecture(23) Integrated system approach to study radiationinduced signaling in a 3D human skin model
16:15 16:40 Lecture(24) Molcular mechanisum of radiation-induced
thyroid cancer
16:40 17:05 Lecture(25) Radiation response of mouse neural stem cells

Sowa MB

PNNL, USASuzuki K

17:05 17:35 Lecture(26) Mechanism of radiation-induced mammary
carcinogenesis

Hei TK

Nagasaki University,Nagasaki
Osaka Prefecture University,
Sakai
Columbia University, USA

17:35 17:55 Summary

Drs Suzuki K and Imaoka T

17:55 18:05 Closing Remark

Morgan WF

Kodama S