CURRICULUM VITAE
Name: Goichi Miyoshi
Work Address: 507, 5th Floor, NYU Neuroscience Institute, Smilow Research Center,
New York University School of Medicine, 522 First Avenue, New York, NY, 10016
Phone: 212-263-7693
Fax: 212-263-9170
Cell: 646-420-3441
e-mail: Goichi.Miyoshi@gmail.com

Education / Research Experience
4/2004-present
NYU Neuroscience Institute, Smilow Research Center / Skirball Institute
New York University School of Medicine, New York, NY
Postdoctoral fellow, laboratory of Dr. Gordon Fishell
4/1999-3/2004
Graduate School of Biostudies, Kyoto University
Graduate student, laboratory of Dr. Ryoichiro Kageyama
Ph.D., Biostudy May 2004
4/1995-3/1999
Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
Bachelor of Science, Engineering, March 1999
Grants / Fellowships
4/2005-3/2007
Japan Society for the Promotion of Science, Postdoctoral Fellowships for
Research Abroad
1/2009-12/2010
NARSAD Young Investigator Award‘Serotonergic Neuromodulation and Cortical Inter Neuron Function as a Model of
Schizophrenia’
Research Background and Techniques
Fishell lab (Postdoc):
I carried out two complementary in vivo inducible genetic fate-mapping studies anddetermined a near complete picture of when and where mouse cortical interneurons subtypes
are produced. I characterized mature morphologies, molecular expression profiles andelectrophysiological properties of interneurons fate-mapped from the various time points of
MGE and CGE (Miyoshi et al., 2007 and 2010, cited 187 and 184 times, respectively). I
have further demonstrated that the coordination of tangential and radial migration phases ofboth GABAergic interneurons (Miyoshi and Fishell, 2011) and pyramidal cells (Miyoshi andFishell, 2012) is critical for the proper assembly of neocortical networks. More recently, I
identified Prox1, as the first known transcription factor that selectively regulates the corticallayering and circuit integration of CGE-derived interneurons.
Kageyama lab (graduate school):
I identified a transcriptional master regulator of GABAergic neurogenesis within thedeveloping midbrain (Miyoshi et al., 2004).

Publications
Google Scholar Link
http://scholar.google.com/citations?hl=en&user=IWdDHMIAAAAJ&view_op=list_works&sortby=pubdate

Miyoshi, G., Young, A., Petros, T., Karayannis, T., Mckenzie Chang, M, Lavado, A., Iwano, T.,
Nakajima, M., Taniguchi, H., Huang, J., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R.P., andFishell, G. (Manuscript submitted). Prox1 regulates the subtype-specific development of caudal
ganglionic eminence-derived GABAergic cortical interneurons
Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell,G., Mori, K., Kageyama, R., and Imayoshi, I. (2014). Continuous postnatal neurogenesis contributes toformation of the olfactory bulb neural circuits and flexible olfactory associative learning. The Journalof Neuroscience 34, 5788-5799.
Miyoshi, G., Machold, R.P., and Fishell, G. (2013). Specification of GABAergic Neocortical
Interneurons. Cortical Development: Neural Diversity and Neocortical Organization, Chapter 5, R.
Kageyama, ed. DOI 10.1007/978-4-431-54496-8_5, Springer Book Chapter.
http://link.springer.com/chapter/10.1007%2F978-4-431-54496-8_5

File link

Miyoshi, G., and Fishell, G. (2012). Dynamic FoxG1 Expression Coordinates the Integration ofMultipolar Pyramidal Neuron Precursors into the Cortical Plate. Neuron 74, 1045-1058.
Allene, C., Picardo, M.A., Becq, H., Miyoshi, G., Fishell, G., and Cossart, R. (2012). Dynamicchanges in interneuron morphophysiological properties mark the maturation of hippocampal network
activity. The Journal of Neuroscience 32, 6688-6698.
Imayoshi, I., Hirano, K., Sakamoto, M., Miyoshi, G., Imura, T., Kitano, S., Miyachi, H., andKageyama, R. (2012). A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- andFlp-mediated recombination. Neuroscience research 73, 85-91.
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsiani, D., Fu, Y., Lu, J., Lin, Y.,
Miyoshi, G., Shima, Y., Fishell, G., Nelson, S.B., and Huang, Z.J. (2011). A resource of Cre driverlines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 71, 995-1013.
Miyoshi, G., and Fishell, G. (2011). GABAergic interneuron lineages selectively sort into specificcortical layers during early postnatal development. Cereb Cortex 21, 845-852.
Jeanneteau, F., Deinhardt, K., Miyoshi, G., Bennett, A.M., and Chao, M.V. (2010). The MAP kinase
phosphatase MKP-1 regulates BDNF-induced axon branching. Nature Neuroscience 13, 1373-1379.

Tricoire, L., Pelkey, K.A., Daw, M.I., Sousa, V.H., Miyoshi, G., Jeffries, B., Cauli, B., Fishell, G., andMcBain, C.J. (2010). Common origins of hippocampal Ivy and nitric oxide synthase expressing
neurogliaform cells. The Journal of Neuroscience 30, 2165-2176.
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V.H., Butt, S.J., Battiste, J., Johnson, J.E.,
Machold, R.P., and Fishell, G. (2010). Genetic fate mapping reveals that the caudal ganglioniceminence produces a large and diverse population of superficial cortical interneurons. The Journal of
Neuroscience 30, 1582-1594.
Sousa, V.H., Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., and Fishell, G. (2009). Characterizationof Nkx6-2-derived neocortical interneuron lineages. Cereb Cortex 19 Suppl 1, i1-10.
Cocas, L.A., Miyoshi, G., Carney, R.S., Sousa, V.H., Hirata, T., Jones, K.R., Fishell, G., Huntsman,
M.M., and Corbin, J.G. (2009). Emx1-lineage progenitors differentially contribute to neural diversity
in the striatum and amygdala. The Journal of Neuroscience 29, 15933-15946.
Butt, S.J., Sousa, V.H., Fuccillo, M.V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., and Fishell, G.
(2008). The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.
Neuron 59, 722-732.
Miyoshi, G., Butt, S.J., Takebayashi, H., and Fishell, G. (2007). Physiologically distinct temporal
cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. The Journal of
Neuroscience 27, 7786-7798.
Battiste, J., Helms, A.W., Kim, E.J., Savage, T.K., Lagace, D.C., Mandyam, C.D., Eisch, A.J., Miyoshi,G., and Johnson, J.E. (2007). Ascl1 defines sequentially generated lineage-restricted neuronal andoligodendrocyte precursor cells in the spinal cord. Development 134, 285-293.
Miyoshi, G., and Fishell, G. (2006). Directing neuron-specific transgene expression in the mouse CNS.
Current Opinion in Neurobiology 16, 577-584.
Akagi, T., Inoue, T., Miyoshi, G., Bessho, Y., Takahashi, M., Lee, J.E., Guillemot, F., and Kageyama,
R. (2004). Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype
specification. The Journal of Biological Chemistry 279, 28492-28498.
Miyoshi, G., Bessho, Y., Yamada, S., and Kageyama, R. (2004). Identification of a novel basic
helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. The Journal of Neuroscience24, 3672-3682.
Satow, T., Bae, S.K., Inoue, T., Inoue, C., Miyoshi, G., Tomita, K., Bessho, Y., Hashimoto, N., andKageyama, R. (2001). The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.
The Journal of Neuroscience 21, 1265-1273.

Bessho, Y., Miyoshi, G., Sakata, R., and Kageyama, R. (2001). Hes7: a bHLH-type repressor gene
regulated by Notch and expressed in the presomitic mesoderm. Genes to Cells : devoted to molecular& cellular mechanisms 6, 175-185.

Publications and Reviews in JapaneseMiyoshi, G. (2014). Development of GABAergic Neocortical Interneurons.
Igaku no Ayumi, Vol. 251, No. 13, 1129-1136, December 27
File link

Miyoshi, G. (2012). Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal
Neuron Precursors into the Cortical Plate.
Life science review, July 11
http://first.lifesciencedb.jp/archives/5201

Invited talks and presentations
Neural Stem Cell Origins of Excitatory and Inhibitory Cortical Neuron Types
Miyoshi, G.
Job Seminar, Institute for Stem Cell and the Department of Neuroscience
Albert Einstein College of Medicine
April 16th (2015)
Excitatory and Inhibitory Circuit Assembly within the Cerebral Cortex
Miyoshi, G.
Picower Special Job Seminar
Brain Cognitive Sciences, The Picower Institute, MIT January 20th (2015)
Assembly of GABAergic inhibitory circuitry within the cerebral cortex
Miyoshi, G.
National Institute of Genetics Symposium “Circuit construction in the mammalian brain”
National Institute of Genetics, Shizuoka, Japan
December 2nd (2014)
Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived corticalinterneurons
Miyoshi, G.
Gordon Research Conference Neural Development
Salve Regina University, Newport, RI, USA August 14th (2012)https://www.grc.org/programs.aspx?year=2012&program=neurdev

Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived corticalinterneurons
Miyoshi, G.
The 35th Annual Meeting of the Molecular Biology Society of Japan
Regulation of Neural Stem Cell Differentiation in Mammalian Neural Development
Organizers: Imayoshi, Itaru (Kyoto Univ.) | Miyoshi, Goichi (Neuroscience Inst., NYU)
Fukuoka International Congress Center, Fukuoka, Japan
December 12th (2012)
GABAergic interneuron lineages selectively sort into specific cortical layers during early postnatal
development
Miyoshi, G.
Annual Research Symposia 2010
Wiring the Nervous System from Brain to Spinal Cord
Speakers: Pasko Rakic (Yale), Goichi Miyoshi (NYU), Raj Awatramani (Northwestern), Gary
Gaufo (UTSA), Jeremy Dasen (NYU HHMI)
University of Texas San Antonio, TX, USA April 9th (2010)
http://neuroscience.utsa.edu/Symposium2010.html

Specification of GABAergic neocortical interneuron subtypes
Miyoshi, G.
Multiple facets of GABA in brain development
INMED Satellite Conference of SFN 2009
Chair Scientific Program Committee: Yehezkel Ben-Ari, INMED France
Prentice Women’s hospital, Chicago, USA October 16th (2009)http://www.frontiersin.org/Community/AbstractDetails.aspx?ABS_DOI=10.3389/conf.neuro.03.2009.13.004&eid=432&sname=IN
MED_Satellite_Conference_of_SFN_-_Neuroscience_2009_Multiple_Facets_of_GABA_in_Brain_Development

Talks and Seminars
Assembly of GABAergic inhibitory circuitry within the cerebral cortex
Miyoshi, G.
Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
November 25, 2014
Prox1 regulates the subtype-specific development of CGE-derived GABAergic cortical interneurons
Miyoshi, G.,
Institute for Virus Research, Kyoto University, Kyoto, Japan
November 26, 2012
Genetic regulation of the development of cortical interneurons and principal cells
Miyoshi, G.,
Global COE seminar, Keio University, Tokyo, Japan
December 6, 2010
Genetic regulation of the development of cortical interneurons and principal cells
Miyoshi, G.,
Director-General Invited Seminar, National Institute for Physiological Sciences, Okazaki, Aichi,
Japan
November 29, 2010
Caudal ganglionic eminence produces a large and diverse population of superficial corticalinterneurons
Miyoshi, G.
Gordon Research Conference Inhibition in the CNS, Colby College, Waterville, ME, USA
July 28, 2009
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes
Miyoshi, G.,
RIKEN Brain Science Institute, Wako, Saitama, Japan
December 5, 2008
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes
Miyoshi, G.,
Nagoya University, Nagoya, Japan
December 4, 2008
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes
Miyoshi, G.,
Institute for Virus Research, Kyoto University, Kyoto, Japan
December 3, 2008
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes
Miyoshi, G.,
RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
December 2, 2008
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes

Miyoshi, G.,
COE seminars, Nara Institute of Science and Technology, Nara, Japan
November 28, 2008
Defining the spatiotemporal origins of GABAergic cortical interneuron subtypes
Miyoshi, G.,
Global COE Seminar, Osaka University, Osaka, Japan
November 26, 2008
Genetic Origins of Cortical Interneuron Subtypes
Miyoshi, G.,
RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
March 7, 2007
Roles of a Novel bHLH Gene, Heslike, in Generation of Mesencephalic GABAergic Neurons
Miyoshi, G.
76th Annual Meeting of the Japanese Biochemical Society, Yokohama, Japan
October 16, 2003
Poster presentations
Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived corticalinterneurons
Miyoshi, G., Young, A., Petros, T., Karayannis, T., Chang, M., Van Versendaal, D., Lavado, A., Iwano,T., Taniguchi, H., Nakajima, M., Huang, J. Z., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R.,
Fishell, G.
44th Annual Meeting of the Society-for-Neuroscience, Washington DC, USA
November 15 -19, 2014
Prox1 regulates the subtype-specific development of CGE-derived GABAergic cortical interneurons
Miyoshi, G., Young, A., Petros, T., Karayannis, T., Chang, M., Lavado, A., Iwano, T., Nakajima, M.,
Taniguchi, H., Huang, J. Z., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R., Fishell, G.
Gordon Research Conference Neural Development, Salve Regina University, Newport, RI, USA
August 10- 15 2014
Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived corticalinterneurons
Miyoshi, G., Young, A., Karayannis, T., Chang, M., Petros, T., Lavado, A., Iwano, T., Taniguchi, H.,
Nakajima, M., Huang, J. Z., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R., Fishell, G.
43rd Annual Meeting of the Society-for-Neuroscience, San Diego, CA, USA
November 09 -13, 2013
Prox1 regulates both the migration and maturation of caudal ganglionic eminence-derived corticalinterneurons
Miyoshi, G., Karayannis, T., Roberta, A., McKenzie, M., Lavado, A., Iwano, T., Taniguchi, H.,
Nakajima, M., Matsuzaki, F., Huang, J. Z., Heintz, N., Oliver, G., Fishell, G.
42nd Annual Meeting of the Society-for-Neuroscience, New Orleans, LA, USA
October 13 -17, 2012

Prox1 regulates the migration and maturation of caudal ganglionic eminence-derived corticalinterneuron subtypes
Miyoshi, G., Young, A., Karayannis, T., Petros, T., Chang, M., Lavado, A., Iwano, T., Taniguchi, H.,
Nakajima, M., Machold, R., Heintz, N., Huang, J. Z., Matsuzaki, F., Oliver, G., Fishell, G.
Gordon Research Conference Neural Development, Salve Regina University, Newport, RI, USA
August 12- 17 2012
Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors
into the Cortical Plate
Miyoshi, G., Fishell, G.
Genomics and Systems Biology, NYU Abu Dhabi, UAE
February 14-16, 2012
Dynamic regulation of FoxG1 is required for the specification and integration of pyramidal neurons
into the cortical plate
Miyoshi, G., Fishell, G.
41st Annual Meeting of the Society-for-Neuroscience, Washington, DC, USA
November 12 -16, 2011
Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors
into the Cortical Plate
Miyoshi, G., Fishell, G.
Janelia conferences, Control of Neuronal Identity, Ashbum, VA, USA
October 9 -12, 2011
Dynamic regulation of FoxG1 is required for the specification and integration of pyramidal neurons
into the cortical plate
Miyoshi, G., Fishell, G.
Cortical Development, Chania, Crete, Greece
May 19 -22, 2011
FoxG1 coordinates the postmitotic integration of pyramidal neurons into the cortical layers
Miyoshi, G., Fishell, G.
40th Annual Meeting of the Society-for-Neuroscience, San Diego, CA, USA
November 13 -17, 2010
FoxG1 coordinates the postmitotic integration of pyramidal neurons into the cortical layers
Miyoshi, G., Fishell, G.
Gordon Research Conference Neural Development, Salve Regina University, Newport, RI, USA
August 15- 20, 2010
Caudal ganglionic eminence uses a novel integration strategy for acquiring their laminar fate in thecortexMiyoshi, G., Hjerling-Leffler, J., Karayannis, T., McKenzie, M., Sousa, V., Battiste, J., Johnson, J.,
Fishell, G.
39th Annual Meeting of the Society-for-Neuroscience, Chicago, IL, USA
October 17 -21, 2009
GABAergic interneuron lineages selectively sort into specific cortical layers during early postnatal
development

Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V., Butt, S.J.B., Battiste, J., Johnson, J.,
Machold, R., Fishell, G.
Gordon Research Conference Inhibition in the CNS, Colby College, Waterville, ME, USA
July 26- 31, 2009
FoxG1 regulates neuronal migration in the cerebral cortex
Miyoshi, G., Sousa, V., Hanashima, C., Fishell, G.
38th Annual Meeting of the Society-for-Neuroscience, Washington, DC, USA
November 15 -19, 2008
Spatiotemporal integration of cortical interneuron subtypes from the CGE is distinct from the MGE
Miyoshi, G., Hjerling-Leffler, J., Sousa, V., Karayannis, T., Butt, S.J.B., Yanagawa, Y., Battiste, J.,
Johnson, J., Fishell, G.
Gordon Research Conference Neural Development, Salve Regina University, Newport, RI, USA
August 17- 22, 2008
FoxG1 regulates neuronal migration in the cerebral cortex
Miyoshi, G., Sousa, V., Hanashima, C., Fishell, G.
Cortical Development, Chania, Crete, Greece
May 22 -25, 2008
FoxG1 specifies the ventral telencephalic cell types
Miyoshi, G., Sousa, V., Hanashima, C., Fishell, G.
37th Annual Meeting of the Society-for-Neuroscience, San Diego, CA, USA
November 3 -7, 2007
The CGE produces temporal cohorts of interneurons that migrate to distinct forebrain regions
Miyoshi, G., Hjerling-Leffler, J., Butt, S.J.B., Sousa, V., Battiste, J., Johnson, J., Fishell, G.
Gordon Research Conference Inhibition in the CNS, Colby College, Waterville, ME, USA
July 22- 27, 2007
Olig2 positive progenitors give rise to specific populations of cortical interneuron subtypes in a
temporally regulated manner
Miyoshi, G., Butt, S.J.B., Takebayashi, H., Fishell, G.
36th Annual Meeting of the Society-for-Neuroscience, Atlanta, GA, USA
October 14 -18, 2006
Physiologically distinct temporal cohorts of cortical interneurons arise from Olig2 Expressing
Progenitors
Miyoshi, G., Butt, S.J.B., Takebayashi, H., Fishell, G.
Gordon Research Conference Neural Development, Salve Regina University, Newport, RI, USA
August 20- 25, 2006
Olig2+ progenitors give rise to specific populations of cortical interneurons and oligodendrocytes in a
temporally regulated Manner
Miyoshi, G., Butt, S.J.B., Takebayashi, H., Fishell, G.
35th Annual Meeting of the Society-for-Neuroscience, Washington, DC, USA
November 11 -16, 2005+
Olig2 progenitors give rise to specific populations of cortical interneurons and oligodendrocytes in a
temporally regulated MannerMiyoshi, G., Butt, S.J.B., Takebayashi, H., Fishell, G.
Cortical Development, Santorini, Greece
May 12 -15, 2005
Specification of GABAergic Neuronal Subtype Identity by bHLH Gene Heslike in Mouse
Mesencephalon
Miyoshi, G., Bessho, Y., Yamada, S., Kageyama, R.
Keystone Symposia Meeting, Signaling in Vertebrate Organogenesis, Santa Fe, NM, USA
February 26 - March 2, 2004
Roles of a novel bHLH gene, heslike, in generation of mesencephalic GABAergic neurons
Miyoshi, G., Bessho, Y., Yamada, S., Kageyama, R.
26th Annual Meeting of the Molecular Biology Society of Japan, Kobe, Hyogo, Japan
December 10 -13, 2003
Roles of a novel bHLH gene, heslike, in generation of mesencephalic GABAergic neurons
Miyoshi, G., Bessho, Y., Yamada, S., Kageyama, R.
33rd Annual Meeting of the Society of Neuroscience, New Orleans, LA, USA
November 08 -12, 2003
Roles of a Novel bHLH Gene, Heslike, in Generation of Mesencephalic GABAergic Neurons
Miyoshi, G., Bessho, Y., Yamada, S., Kageyama, R.
76th Annual Meeting of the Japanese Biochemical Society, Yokohama, Japan
October 15 -18, 2003
Roles of a novel bHLH gene, heslike, in generation of mesencephalic GABAergic neurons
Miyoshi, G., Bessho, Y., Yamada, S., Kageyama, R.
36th Annual Meeting of the Japanese Society of Developmental Biologists, Sapporo, Hokkaido,
Japan
June 11 -13, 2003

References

Gordon Fishell
Professor and Director of Smilow Neuroscience Program
Associate Director of the NYU Neuroscience Institute
5th flr. Smilow Research Building
NYU Langone School of Medicine
522 1st Ave, New York, NY, 10016
Phone: 212-263-7691
Fax: 212-263-2248
email: fisheg01@nyumc.org
http://med.nyu.edu/fishelllab/

Alexandra L. Joyner
Courtney Steel Chair in Pediatric Cancer Research
Memorial Sloan-Kettering Cancer Center
Developmental Biology Program, Sloan-Kettering InstituteRockefeller Research Labs, rm 701
430 E. 67th St., New York, NY 10065
Office: 212-639-3962;
Fax: 212-717-3738; Lab: 212-639-3980
email: joynera@mskcc.org
http://www.ski.edu/joyner
Assistant: Cara Monaco e-mail: monacoc@mskcc.org; phone: 212-639-3929

Ryoichiro Kageyama
Laboratory of Growth Regulation
Institute for Virus Research, Kyoto University
53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan
Phone: +81-75-751-4011
Fax: +81-75-751-4807
email: rkageyam@virus.kyoto-u.ac.jp
http://www.virus.kyoto-u.ac.jp/Lab/Kageyama/index_English.html