November 20, 2018
NEWS RELEASEKYORIN Holdings, Inc.
(Securities Code: 4569, TSE 1st Sec.)
Kissei Pharmaceutical Co., Ltd.
(Securities Code: 4547, TSE 1st Sec.)

Launch of “Beova® Tablets 50mg” for the Treatment of Overactive Bladder
KYORIN Pharmaceutical Co., Ltd. (Head Office: Chiyoda-ku, Tokyo, President & CEO:Minoru Hogawa, “KYORIN”), a subsidiary of KYORIN Holdings, Inc. (Head Office:Chiyoda-ku, Tokyo, President & CEO: Minoru Hogawa), and Kissei Pharmaceutical Co., Ltd.
(Head Office: Matsumoto City, Nagano, Chairman & CEO: Mutsuo Kanzawa, “Kissei”) will
launch “Beova® Tablets 50mg (“Beova® Tablets”)” for the treatment of overactive bladder on
November 27, 2018.
KYORIN signed a license agreement with Merck & Co., Kenilworth, N.J., U.S.A. (Head office: NewJersey, U.S.A., CEO: Kenneth C. Frazier) in July 2014 concerning the grant of an exclusive license todevelop, manufacture and market this agent in Japan. The product has been jointly developed byKYORIN and Kissei under a co-development and co-marketing agreement entered into as of March 2016.
KYORIN subsequently received manufacturing and marketing approval in September 2018,
and after the NHI price listing on November 20, 2018, the drug will now be launched.
Vibegron, an active ingredient of Beova® Tablets, is a novel once-daily oral treatment for
overactive bladder (OAB), acts selectively on the bladder's β3-adrenergic receptor, relaxes
the bladder and enhances the urine collection, and consequently improves the symptoms ofurgency, urinary frequency and urge urinary incontinence associated with OAB.
The characteristics of “Beova® Tablets” are as follows:①Demonstrated significant improvement in OAB symptoms urinary urgency, urinaryfrequency, and urge urinary incontinence with once daily administration compared withthe placebo group.
② Improved all domeins on the King’s Health Questionnaire*2, an indicator of QOL.
③Maintained Effects up to 52 weeks of administration.
Both KYORIN and Kissei have positioned the urology field as one of their respective
strategic areas, will continuously work for OAB patients by offering this new therapeutic
option with smooth penetration into the market.
*1 OAB：Overactive Bladder*2 King’s Health Questionnaire：KHQA QOL questionnaire specific to urinary incontinence that is comprised of 19 items in 8 areas, and has been
confirmed to also be valid for overactive bladder###Corporate Communications
KYORIN Holdings, Inc.
TEL: +81-3-3525-4707

Contacts
Public Relations
Kissei Pharmaceutical Co., Ltd.
TEL: +81-263-25-9523

About Beova®
Beova® Tablets 50mg
Vibegron
Urinary urgency, urinary frequency and urge urinary incontinence
associated with overactive bladder
Dosage and administration: The usual oral dosage for adults is 50mg of vibegron once daily after meal.
NHI price :¥ 185.70
Packaging:
100 tablets（PTP10 × 10） 、140 tablets（PTP14 × 10）
Date of Drug Price Listing: November 20, 2018
Date of Launch in Japan:
November 27, 2018

Product Name:
INN:
Indications:〈 product photo〉Kyorin：Beova® Tablets 50mg

About Overactive Bladder (OAB)
Overactive bladder (OAB) is a condition with the symptoms such as "urinary urgency (sudden,
desire to pass urine that is difficult to defer)", "urinary frequency (the condition where urination is more
often than usual)" and "nocturia" resulting from aging, neurological disorder etc.
Symptom prevalence of OAB tends to increase with advancing age, and OAB patients in Japan are
estimated to be 10.4 million from the population structures in 2012*. In step with the aging of thepopulation, OAB patients is expected to further increase, and the contribution of OAB medication to theimprovement of the health including QOL is considered meaningful.
*Clinical Guidelines for Overactive Bladder Syndrome 2nd Edition, The Japanese Continence Society