HEALTH - FOODK E Y H E L P T O S O LV E A B D O M I N A L B L O AT I N GAND ENJOY A BETTER LIFE

CUBO™

CURCUMIN PHYTOSOME + BOSWELLIA PHYTOSOME™
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only, hence they do not refer to finished products and they may not comply with Regulation EC n. 1924/2006.
The marketer of any finished product containing any ingredient is responsible for assuring that thedestination of the product and the claims made for the finished product are lawful and comply withall applicable laws and regulations of the country or countries in which the product is to be sold.

Moreover, 20-30% of the general
population suffers from functional
gastrointestinal discomfort.
Scientific evidence has repeatedly
shown the potential beneficial effects of
curcumin and boswellia on gut health:2,3
that’s how the concept behind CUBO™ wasborn, leveraging their combined effect for
intestinal wellbeing.
CUBO™ is a specific and balanced
formulation, in which Curcuma longa
Phytosome and Boswellia serrata
Phytosome are carefully blent to bring
together the beneficial actions these twonatural ingredients offer for gut health.

This innovative combination - made possible by
Phytosome technology2,8,9 - opens up a new dimension
of gut health, with a beneficial effect on intestinal
discomfort thanks to two botanicals that positively
control gut microbiota and gut motility,5-7 offering relief
from bloating, abdominal discombfort and cramps.4
In a 30 days double-blind randomized human study on
49 subjects, compared to the group administered with
only LOW-FODMAP diet, the one also taking 380 mg of
CUBO™ twice a day has shown:•BLOATING CONTROL-83% BLOATING INTENSITY SCORE(vs. -33% in the group with LOW-FODMAP diet only)•The fixed ratio of the two Phytosome andtheir accurate dosage were determinedwith a series of specific tests, focusedon finding the right balance between
minimum required dosage and maximum
expected benefit.

ABDOMINAL DISCOMFORT CONTROL-80% ABDOMINAL DISCOMFORT SCORE(vs. -37% in the group with LOW-FODMAP diet only)•SMALL BOWEL MICROBIOTA BALANCE-50% URINARY INDICAN(vs. -5% in the group with LOW-FODMAP diet only)

SCIENTIFIC EVIDENCE
A double-blind randomized human study
has recently shown a significant control inbloating intensity, abdominal discomfort
and gut dysbiosis after 30 days of CUBO™
supplementation.4

Moreover, researchers also conducted a global efficacy
assessment, measuring the perception of healthimprovements after supplementation: 92% of theCUBO™ group was assigned higher efficacy classes (3or 4), compared to only 12% of the control group.

RECOMMENDED USE AND DOSE
CUBO™ is a yellow to orange powder andmay be utilized in a variety of supplement
formulations.
Recommended dose: 380 mg twice a day

This means that CUBO™ - the winning duo of curcumin
Phytosome and boswellia Phytosome - has proved
significant capabilities in improving people’s gut health,with over 90% of people claiming their conditions werenoticeably better.

TRADEMARKSCUBO™ is a trademark of Indena S.p.A. andits logo and usage guidelines are available
from Indena.
References
1Ryu MS. et al., J Neurogastroenterol Motil. 2016 Jul 30; 22(3):509-16
2Pellegrin L. et al., Eur Rev Med Pharmacol Sci. 2016 Jun; 20(12):2695-700
3Scazzocchio B. et al., Nutrients. 2020 Aug 19; 12(9):2499
4Data to be published
5Riva A. et al., Minerva Gastroenterologica e Dietologica 2019; 65(1):30-5
6Gunes H. et al., Toxicol Ind Health. 2016 Feb; 32(2):246-50
7Jurenka JS., Altern Med Rev. 2009 Jun; 14(2):141-53
8Riva A. et al., Phytomedicine. 2016 Nov 15; 23(12):1375-1382
9Cuomo J. et al., J Nat Prod. 2011 Apr 25; 74(4):664-9DPR0216 - 05/2023

Curcumin Phytosome and Boswellia Phytosome make
CUBO™ the right formula for intestinal health.

trademarks of Indena S.p.A. © 2023, Indena S.p.A.

Abdominal bloating is one of the mostfrequent conditions in subjects withgastrointestinal disorders such as irritablebowel syndrome (IBS).1,

WHAT MAKES CUBO™ UNIQUE?

® TM

WHAT IS CUBO™?