Curriculum vitae
Yusuke Hirabayashi Ph.DRoom 1104
Northwest Corner Building
550 W. 120th St.
New York, NY 10027
yh2674@cumc.columbia.edu
Work Experience
November 2013 – Post Doctoral Fellow
Franck Polleux lab, Department of Neuroscience, Columbia University
March 2013 – October 2013

Research AssociateFranck Polleux lab, Department of Cell Biology, The Scripps Research Institute
April 2007 – February 2013

Research Associate

Laboratory of Cell Signaling (Yukiko Gotoh Lab.), Institute of Molecular andCellular Biosciences, The University of Tokyo
April 2006 - March 2007

Research Fellow

Laboratory of Cell Signaling (Yukiko Gotoh Lab.), Institute of Molecular andCellular Biosciences, The University of Tokyo

Education
April 2003 - March 2006

Ph. D. student

Graduate School of Frontier Sciences, The University of Tokyo Awarded thedegree of Ph.D. (Mar 23, 2006). (Supervisor: Yukiko Gotoh)
Thesis Title: Roles of the canonical Wnt pathway in neocortical neural precursor
cells (Hirabayashi et al., Development 2004).
April 2001 - March 2003

M.S. student

Graduate School of Frontier Sciences, The University of Tokyo Awarded the1degree of M.S. (Supervisor: Yukiko Gotoh)
April 1997 - March 2001

Undergraduate student

Faculty of Engineering, University of Tokyo (Tokyo, Japan).

Awarded thedegree of B.E. (Supervisor: Takuzo Aida)

Fellowship:Present support
The Uehara Memorial Foundation
March 2015 – February 2016
Past support
Japan society promotion of science fellowship for research abroadFebruary 2013 – February 2015
Japan society promotion of science fellowship for Japanese junior scientists,
2003-2006
Grant:The role of Polycomb group proteins in the spatial allocation of neocortical
functional areas (MEXT)
2011-2013
Analysis of the polycomb mediated regulation of neural stem cell multipotency
2011-2013 (JSPS)
Temporal regulation of cortical neural precursor cell fate by polycomb groupproteins2009-2011 (MEXT)
The coupling of proliferation and differentiation of neural stem cells by Wnt
signaling
2008-2010 (JSPS)
2The analysis of the mechanisms regulating the temporal changes of neurons
produced from neural stem cells.
2008-2010 (JSPS)
The mechanism regulating the length of neuronal production
2007-2009 (MEXT)

Teaching experience and responsibilities:
Exercise Class of biology (2007-12), University of Tokyo
Ph.D./Master’s Theses Trainees (2007-2013), University of Tokyo

Publications:
Original, Peer Reviewed Articles:
Slowly dividing neural progenitors are an embryonic origin of adult neural stemcellsShohei Furutachi, Hiroaki Miya, Tomoyuki Watanabe, Hiroki Kawai, Norihiko
Yamasaki, Yujin Harada, Itaru Imayoshi, Mark Nelson, Keiichi I Nakayama,
Yusuke Hirabayashi and Yukiko Gotoh
Nature Neuroscience 2015, 18 (5), 657–665
Up-regulation of HP1γ expression during neuronal maturation promotes axonal
and dendritic development in mouse embryonic neocortex
Hiroaki Oshiro, Yusuke Hirabayashi, Yasuhide Furuta, Shigeo Okabe andYukiko Gotoh
Genes to Cells 2015, 20(2), 108-20
The polycomb component Ring1B regulates the timed termination ofsubcerebral projection neuron production during mouse neocorticaldevelopment
Nao Morimoto-Suzki, Yusuke Hirabayashi* (*co-correspondence), Kelsey
Tyssowski, Jun Shinga, Miguel Vidal, Haruhiko Koseki, and Yukiko Gotoh*Development 2014, 141 (22), 4343-4353

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Tcf3 Represses Wnt–β-Catenin Signaling and Maintains Neural Stem CellPopulation during Neocortical Development
Atsushi Kuwahara , Hiroshi Sakai , Yuanjiang Xu , Yasuhiro Itoh, Yusuke
Hirabayashi* (*correspondence), Yukiko Gotoh
PLOS ONE. 2014 9;5:e94408
A noncoding RNA regulates the neurogenin1 gene locus during mouseneocortical development
Masahiro Onoguchi, Yusuke Hirabayashi, Haruhiko Koseki, Yukiko Gotoh
Proc Natl Acad Sci USA. 2012 109(42):16939-44.
HMGA regulates the global chromatin state and neurogenic potential in
neocortical precursor cells
Yusuke Kishi, Yuki Fujii, Yusuke Hirabayashi, Yukiko Gotoh
Nature Neuroscience 2012 15 (8):1127-33.
PDK1 regulates the generation of oligodendrocyte precursor cells at an earlystage of mouse telencephalic development
Kenji Watatani, Yusuke Hirabayashi, Yasuhiro Itoh, Yukiko Gotoh
Genes Cells. 2012 17 (4):326-35*Epigenetic control of neural precursor cell fate during development
Yusuke Hirabayashi and Yukiko Gotoh
Nature Reviews Neuroscience 2010, 11 (6) 377-388
Wnt signaling and its downstream target N-Myc regulate basal
progenitors in the developing neocortex
Atsushi Kuwahara, Yusuke Hirabayashi*(*co-correspondence), Paul S.
Knoepfler, Makoto M. Taketo, Juro Sakai, Tatsuhiko Kodama, andYukiko Gotoh*
Development 2010, 137 (7), 1035-1044*Polycomb limits the neurogenic competence of neural precursor cells topromote astrogenic fate transitionYusuke Hirabayashi, Nao Suzki, Masafumi Tsuboi, Takaho A Endo, Tetsuro
Toyoda, Jun Shinga, Haruhiko Koseki, Miguel Vidal and Yukiko Gotoh
Neuron 2009, 63 (5), 600-13
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release
Yasunori Mori, Maiko Higuchi, Yusuke Hirabayashi, Mitsunori Fukuda. andYukiko Gotoh
EMBO J. 2008, 27 (1), 76-87*Stage-dependent fate determination of neural precursor cells in mouse4forebrain
Yusuke Hirabayashi and Yukiko Gotoh
Neuroscience Research 2005, 51 (4) 331-336*The Wnt-beta-catenin pathway directs neuronal differentiation of cortical neuralprecursor cells
Yusuke Hirabayashi, Yasuhiro Itoh, Hidenori Tabata, Kazunori Nakajima, TetsuAkiyama, Norihisa Masuyama and Yukiko Gotoh
Development 2004, 131 (12), 2791-2801
A Supramolecular Oscillator Composed of Carbon Nanocluster C120 and a
Rhodium(III) Porphyrin Cyclic Dimer
Kentaro Tashiro, Yusuke Hirabayashi, Takuzo Aida, Kazuhiko Saigo, Koichi
Fujiwara, Koichi Komatsu, Shigeru Sakamoto, and Kentaro Yamaguchi
J. Am. Chem. Soc. 2002, 124 (41), 12086–12087.
Cyclic Dimers of Metalloporphyrins as Tunable Hosts for Fullerenes: A
Remarkable Effect of Rh(III)
Jian–Yu Zheng, Kentaro Tashiro, Yusuke Hirabayashi, Kazushi Kinbara,
Kazuhiko Saigo, Takuzo Aida, Shigeru Sakamoto, and Kentaro Yamaguchi
Angew. Chem. Int. Ed. 2001, 40 (10), 1857–1861

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