AE*/, 1 x 3,910(2020/5/19)

+x6hikuO7Uf[iku^AE]0TXhQf
FikuO7y→qtrum^
&^1AEiku^H;a#Ix
H;OPLyy]3Y^D Nd.%Sgfv@(viku4%vAE GVgWgh3>UfR[OAE ,hLR\Uno,?^-=<: _ikuOJ`bULcM]58]TZLfiku^'YCjpslw_BH[H;]0
z: iku^H;
m: iku^AEv: iku^B
U: BHrm: 2)$B: 6"J` TXiku^)Oe _CE]0KH;[D6]0TZv]^!h1

8 ;  # ( a " - 7 N
"-7N, L)  KSBRDL,8;b ``UV_T$GR<LNN5bH1 8; (unified atomic mass unit)ba1H 1.00783, 13C 13.0034
 ;b+N0MA@J8;L&T3EI :NuMGR&a*0(12CC98.9%, 13CC1.1%)N ; = 12.0000?98.9%+13.0034?1.1% = 12.011'0(1HC99.99%, 2HC0.01%)N ; = 1.00783?99.99%+2.0141?0.01% = 1.00794
;bT$GR

N;N)KSBRDLUV_N8;≈6!N8;CSBR
=N8;#X\WY^

29a UV_N.
%9a8;L>4N&m/z←
m/zO[]Z^8;LPQF
[]Z^8;a[]Z^8;N5/aC3H8 : 12?3+1?8=44
CO2 : 12+16?2=44

2

! "    UBCS7!"≈!"GMDIQBCSJTD3   JTD7!")@(>BCS)-0,5!"7JTD:,?>(KPENSHTFOSU6 -+;=9/)
:*5!"7JTD8

7$# A128
LRIS,?0

JTDC7H6ClNO7GMDIQ

.A1 2:47)&+1!"75>JTDA'>9?>(6<=98.9%7%99.985%6%75.77%%99.634%%99.762%
98.9%6%1.1%%99.985%6%75.77%%99.634%%99.762%
98.9%7%99.985%5%0.015%%75.77%%99.634%%99.762%
98.9%7%99.985%6%75.77%%0.366%%99.762%
98.9%7%99.985%6%75.77%%99.634%%0.038%
98.9%5%1.1%2%99.985%6%75.77%%99.634%%99.762%
98.9%7%99.985%4%0.015%2%75.77%%99.634%%99.762%
98.9%7%99.985%6%24.23%%99.634%%99.762%
98.9%7%99.985%6%75.77%%99.634%%0.200%
98.9%6%1.1%%99.985%5%0.015%%75.77%%99.634%%99.762%3

,!#&$ !  $  ,35Cl (76%), 37Cl (24%) = 3:1
,79Br (51%), 81Br (49%) = 1:1
'n($*+)%(3a+1b)n$$#"&
(3a+1b)2 = 9a2 + 6ab + b2 →9:6:1(3a+1b)3 = 27a3 + 27a2b + 9ab2 + b3 →27:27:9:1(3a+1b)4 = 81a4 + 108a3b + 36a2b2 + 12ab3+ b4 →81:108:36:12:1
'n($*+)%(a+b)n$$#"&
(a+b)2 = a2 + 2ab + b2 →1:2:1(a+b)3 = a3 + 3a2b + 3ab2 + b3 →1:3:3:1(a+b)4 = a4 + 4a3b + 6a2b2 + 4ab3+ b4 →1:4:6:4:14' )    V *!#(14N)V;)8; 8! # QTQ

F5(PMQ CH3FGON NH2:.48%.E=#0UC+')0U.D82A3-)⇔;!#F ?or!#F >9- <;)*

(#()V

#0n;0GQHS7,E=+2n+2;#F5→GQKS9B2n;#+GQIS9B2n-2;#+LJRGQHS9B2n;#F5→GQHS/B-15;#0(26-D/F&"2+27D8π$ 8 ;F@BED

* W5  = ( # $  ) - TNPM R ) - T  - = + 0 < 8 0 9(#$)-X %<809!1= =$;)-E"09(#57GHS@7>=)- (QNFGJLOKI)-:A?)NPMR)-X

=A0-XE6C

==)-E<*59(57GHST=)--=X1 mol==)-(g)X,4E-C:2<"WC3H8 : 12.3+1.8=44
CO2 : 12+16.2=44



WC3H8 : 12.000.3+1.00783.8=44.0626
CO2 : 12.000+15.9949.2=43.9898

ChemDraw=Analysis&' 4DC)-3:=(#$)X==)-OUI=

-XV/7B=)-6

# $    K!  '39;

# $ 1'    #$(accurate mass)>7:=<3' 3*(/5  #$1! #$4"+49;-,2=620+.(1 )<'

4! #$+5002:"3ppm
500-8002:"4ppm
800-10002:"5ppm

%PEG600 (  $6004
EF?CHI@FAJG)
CH2 CH2 O

nunit FW = 44.0262

http://www.jeol.co.jp/support/analysis/analysis-ms.html (MSDJB&Vol.2)

KPEG400, PEG600, PEG1000...
PFK [perfluorokerosene: CF3(CF2)nCF3]
CsI [Csn+1In]+8[CsnIn+1]–+-=<YOKUDERUNA (CF3COONa)YOKUDEMASS-7000 (C3F7COONa)

7

& '    V - : F GT  +)

#FGT(EI: electron ionization or electron impact) ;
?:FGT &'=1000>8,$!3 , 4:NULPUK3.C✕ <*3 D@7/
(OSIQTMUJRT)✕6@7/%;621:/

FGT(CI: chemical ionization) ;
 &'=1000>8,$!3 ,EIAB? 36 D;5/,HK;CH2Cl2E09(FGT? "M + Cl– → [M-Cl]–✕6@7/%;621:/

8 !    @ % , 3 4?  #"(FAB: fast atom bombardment);8=756+()!/3000 0*$  .&1 $-,1 $9:<> * *'2✕   

9126VY]_ST^ " ` 9 G S T^

"7"(ESI: electrospray ionization)(I'#H6R;>PE

12J100,000,KD/MeOH/CH3CN/THFGFR$ 'E@C+8?LIZYWXN.T\U[_GFM& /8ST^<*APID&-IST^DM?QP
834GFI(M)!HOBCJ& /✕

%VY]_ST^"(CSI: coldspray ionization)

805@NA:I34N
0@NA:3
(R&D=POrg. Lett. 2001, 3, 1793.

10()㩷 㩷 [㩷㩷 /㩷: E㩷G㩷 㩷 X  SNUMHKWZJZ'*EGX(MALDI: matrix-assisted laser desorption ionization)㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷㩷    㩷㩷㩷㩷㩷 㩷㩷DSNUMHK856DA ()=1,000,000# >7.?! <,0EGX. 1@, >7 &.LXOH(< 2&;:B
  Na+[M + Na]+DART MS (DART: direct analysis in real time)+1@<+7QUFT2EGX4C

YY<IXPVD"&.TLC<KRMND"73B. $%:9D"73B.LXOH(< 2&;:BSpot CSpot B

30mm

Spot A11㩷 㩷㩷 㩷㩷㩷㩷㩷㩷 㩷 㩷㩷 !    Q & 2 = >N  $=>N(APCI: atmospheric pressure chemical ionization)4<FPCP(400℃)1BHLP-0
-.  )@ME"1=>N,;.3 !5100061%34#'O1=>N
-3*'43 
 

http://www.an.shimadzu.co.jp/lcms/it-tof11.htm

=>N(APPI: atmospheric pressure photo-ionization)4<FPCP(400℃)1BHLP-0 !5100061%APCI89743(:%GK?INDPAJN) +93*'
ESI vs. APCI vs. APPI3/'0

12