Hidenori Yamasue

Curriculum Vitae
April, 2015
Hidenori Yamasue, M.D., Ph. D.

Department of Neuropsychiatry
Graduate School of Medicine
University of Tokyo
7-3-1, Hongo, Bunkyo-ku
Tokyo 113-8655, Japan
Phone:
Fax:
E-mail:+81-3-5800-9263+81-3-5800-6894
yamasue-tky@umin.ac.jp

Date of Birth:
Place of Birth:May. 15, 1973
Kanagawa, Japan

Education:
2006 Ph.D.

Graduate School of Medicine, University of Tokyo

1998 M.D.

Yokohama City University, School of Medicine

Brief business background:2009-current Associate Professor and Co-director, Department of Neuropsychiatry,
Graduate School of Medicine, University of Tokyo
2008

Associate Professor, Department of Neuropsychiatry, Graduate School ofMedicine, University of Tokyo

2006-2008

Assistant Professor, Department of Neuropsychiatry, Graduate School ofMedicine, University of Tokyo

2002-current Visiting Researcher, Laboratory for Molecular Dynamics of Mental Disorders,Brain Science Institute, RIKEN, Wako, Japan
2000- 2006

Specialty Doctor, Clinical and Research Fellow, Department ofNeuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo,Japan

1998-2000

Resident, Department of Neuropsychiatry, Tokyo Metropolitan Matsuzawa
Hospital, Tokyo, Japan1

Hidenori Yamasue

Licensure and Certification:
2008

Board certified psychiatrist

2003

A designated psychiatrist

1998

Japanese Medical License Registration

Hospital Appointments:
2013-current Chief outpatient phisician in Department of Neuropsychiatry at University ofTokyo Hospital, Tokyo, Japan
2007-2010

Chief inpatient phisician in Department of Neuropsychiatry at University ofTokyo Hospital, Tokyo, Japan

Memberships, Offices and Committee Assignments in Professional Societies:
2014-

Field editor of Psychiatry and Clinical Neuroscience

2014-

Academic editor of PLOS ONE

2013-

Member and Councilor of Japanese Society of Neuropsychopharmacology

2010-

Member of Society of Biological Psychiatry

2010-Member of Society for Neuroscience2009-

Member of Japan Neuroscience Society

2007-

Member and Councilor of Japanese Society of Anxiety Disorder

2006-

Councilor of Japanese Society of Biological Psychiatry

2004-

Editorial board member of Neuroscience Imaging, Nova -science publishers

2000-

Member of Japanese Society of Biological Psychiatry

Major Research Interest:
Clinical trial initiated by medial investigator utilizing biomarker as outocome
Imaging genetics
Structural & functional neuroimaging in neuropsychiatry

BIBLIOGRAPHY
Major publications:
Original Papers (* corresponding author)
Aoki Y, Yahata N, Watanabe T, Takano Y, Kawakubo Y, Kuwabara H, Iwashiro N, Natsubori T,
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Hidenori Yamasue

Inoue H, Suga M, Takao H, Sasaki H, Gonoi W, Kunimatsu A, Kasai K, and Yamasue H*.
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism.
Brain 137(Pt 11):3073-86. 2014.
Aoki Y, Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Takao
H, Kawakubo Y, Kasai K, and Yamasue H*. Oxytocin's neurochemical effects in the medial
prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized
controlled trial. Molecular Psychiatry 20(4), 447-453, 2015
Natsubori T, Hashimoto R, Yahata N, Inoue H, Takano Y, Iwashiro N, Koike S, Gonoi W, Sasaki
H, Takao H, Abe O, Kasai K, and Yamasue H*. An fMRI study of visual lexical decision inpatients with schizophrenia and clinical high-risk individuals. Schizophrenia Research,157(1-3): 218-24, 2014.
Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao
H, Kawakubo Y, Kamio Y, Kato N, Miyashita Y, Kasai K, and Yamasue H*. Mitigation ofSociocommunicational Deficits of Autism Through Oxytocin-Induced Recovery of Medial
Prefrontal Activity: A Randomized Trial. JAMA psychiatry, 2014;71(2):166-75.
Natsubori T, Inoue H, Abe O, Takano Y, Iwashiro N, Aoki Y, Koike S, Yahata N, Katsura M,
Gonoi W, Sasaki H, Takao H, Kasai K, and Yamasue H*. Reduced frontal Glutamate+Glutamineand N-acetylaspartate levels in patients with chronic schizophrenia but not in those atclinical-high risk for psychosis or with first-episode schizophrenia. Schizophrenia Bulletin,40:1128-39,2014.
Saito Y, Suga M, Tochigi M, Abe O, Yahata N, Kawakubo Y, Liu X, Kawamura Y, Sasaki T,
Kasai K, and Yamasue H*. Neural correlate of autistic-like traits and a common allele in theoxytocin receptor gene. Social Cognitive and Affective Neuroscience. 9:1443-50, 2014.
Watanabe T, Yahata N, Kawakubo Y, Inoue H, Takano Y, Iwashiro N, Natsubori T, Takao H,Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Abe O, Kasai K, Yamasue H*.
Network structure underlying resolution of conflicting nonverbal and verbal social information.
Social Cognitive and Affective Neuroscience. 9:767-75,2014.
Iwashiro N, Yahata N, Kawamuro Y, Kasai K, and Yamasue H*: Aberrant interference ofauditory negative words on attention in patients with schizophrenia. PLOS ONE 8(12):e83201,2013.
Kuwabara H, Yamasue H*, Koike S, Inoue H, Kawakubo Y, Kuroda M, Takano Y, Iwashiro N,Natsubori T, Aoki Y, Kano Y, and Kasai K. Altered metabolites in the plasma of autism spectrum
disorder: a capillary electrophoresis time-of-flight mass spectroscopy study. PLOS ONE, 2013,8(9):e73814.
Aoki Y, Orikabe L, Takayanagi Y, Yahata N, Mozue Y, Sudo Y, Ishii T, Itokawa M, Suzuki M,
Kurachi M, Okazaki Y, Kasai K, Yamasue H*: Volume reductions in frontopolar and left
perisylvian cortices in methamphetamine induced psychosis. Schizophrenia Research,
2013;147(2-3):355-61
Aoki Y, Abe O, Yahata N, Kuwabara H, Natsubori T, Iwashiro N, Takano N, Inoue H, Kawakubo
Y, Gonoi W, Sasaki H, Murakami M, Katsura M, Nippashi Y, Takao H, Kunimatsu A, Matsuzaki
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Hidenori Yamasue

H, Tsuchiya KJ, Kato N, Kasai K, Yamasue H*. Absence of age-related prefrontal NAA change
in adults with autism-spectrum disorders. Translational Psychiatry. 2: e178, 2012.
Watanabe T, Yahata N, Abe O, Kuwabara H, Inoue H, Takano Y, Iwashiro N, Natsubori T, Aoki
Y, Takao H, Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Kawakubo Y,
Matsuzaki H, Tsuchiya KJ, Kato N, Kano Y, Miyashita Y, Kasai K, Yamasue H*. Diminishedmedial prefrontal activity behind autistic social judgments of incongruent information. PLoS One.
7: e39561, 2012.
Yamasue H*, Suga M, Yahata N, Inoue H, Tochigi M Abe O, Liu X, Kawamura Y, Rogers MA,Takei K, Yamada H, Aoki S, Sasaki T, Kasai K. Reply to "Neurogenetic effects of OXTR
rs2254298 in the extended limbic system of healthy Caucasian adults". Biological Psychiatry. 70:41-42, 2011.
Orikabe L, Yamasue H*, Inoue H, T Yoichiro, Mozue Y, Sudo Y, Ishii T, Itokawa M, Suzuki M,Kurachi M, Okazaki Y, Kasai K. Reduced amygdala and hippocampal volumes in patients withmethamphetamine psychosis. Schizophrenia Research. 132: 183-189, 2011.
Inoue H, Yamasue H*, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H,Rogers MA, Aoki S, Sasaki T, Kasai K. Association between the oxytocin receptor gene (OXTR)
and amygdalar volume in healthy adults. Biological Psychiatry.68:1066-1072. 2010.
Yamasaki S, Yamasue H*, Abe O, Suga M, Yamada H, Inoue H, Kuwabara H, Kawakubo Y,Yahata N, Aoki S, Kano Y, Kato N, Kasai K. Reduced gray matter volume of pars opercularis isassociated with impaired social communication in high-functioning autism spectrum disorders.
Biological Psychiatry. 68:1141-1147. 2010.
Yamasue H*, Abe O, Suga M, Yamada H, Rogers MA, Aoki S, Kato N, Kasai K. Sex-Linked
neuroanatomical basis of human altruistic cooperativeness. Cerebral Cortex. 18: 2331-2340,
2008.
Yamasue H*, Kakiuchi C, Tochigi M, Inoue H, Suga M, Abe O, Yamada H, Sasaki T, Rogers
MA, Aoki S, Kato T, Kasai K. Association between mitochondrial DNA 10398A>G
polymorphism and the volume of amygdala. Genes, Brain and Behaviour. 7: 698-704, 2008.
*Kasai K, *Yamasue H (*Equal contribution), Gilbertson MW, Shenton ME, Rauch SL, Pitman
RK. Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study ofcombat-related posttraumatic stress disorder. Biological Psychiatry. 63: 550-556, 2008.
Yamasue H*, Abe O, Suga M, Yamada H, Inoue H, Tochigi M, Rogers M, Aoki S, Kato N, Kasai
K. Gender-common and -specific neuroanatomical basis of human anxiety-related personality
traits. Cerebral Cortex. 18: 46-52, 2008.
Yamasue H*, Abe O, Kasai K, Suga M, Iwanami A, Yamada H, Tochigi M, Ohtani T, Rogers
MA, Sasaki T, Aoki S, Kato T, Kato N. Human brain structural change related to acute single
exposure to sarin. Annals of Neurology. 61: 37-46, 2007.
Yamasue H*, Ishijima M, Abe O, Sasaki T, Yamada H, Suga M, Rogers M, Minowa I, Someya R,Kurita H, Aoki S, Kato N, Kasai K. Neuroanatomy in monozygotic twins with Asperger disorder
discordant for comorbid depression. Neurology. 65: 491-492, 2005.
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Hidenori Yamasue

Yamasue H*, Yamada H, Yumoto M, Kamio S, Kudo N, Uetsuki M, Abe O, Fukuda R, Aoki S,
Ohtomo K, Iwanami A, Kato N, Kasai K. Abnormal association between reduced magnetic
mismatch field to speech sounds and smaller left planum temporale volume in schizophrenia.
Neuroimage. 22: 720-727, 2004.
Yamasue H*, Iwanami A, Hirayasu Y, Yamada H, Abe O, Kuroki N, Fukuda R, Tsujii K, Aoki S,Ohtomo K, Kato N, Kasai K. Localized volume reduction in prefrontal, temporolimbic, andparalimbic regions in schizophrenia: an MRI parcellation study. Psychiatry Research
Neuroimaging. 131: 195-207, 2004.
Yamasue H*, Fukui T, Fukuda R, Kasai K, Iwanami A, Kato N, Kato T. Drug-induced
parkinsonism in relation to choline-containing compounds measured by 1H-MR spectroscopy in
putamen of chronically medicated patients with schizophrenia. International Journal of
Neuropsychopharmacology. 6: 353-360, 2003.
Yamasue H*, Kasai K, Iwanami A, Ohtani T, Yamada H, Abe O, Kuroki N, Fukuda R, Tochigi
M, Furukawa S, Sadamatsu M, Sasaki T, Aoki S, Ohtomo K, Asukai N, Kato N. Voxel-based
analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stressdisorder due to terrorism. Proceedings of National Academy of Sciences USA. 100: 9039-9043,
2003.
Yamasue H*, Fukui T, Fukuda R, Yamada H, Yamasaki S, Kuroki N, Abe O, Kasai K, Tsujii K,Iwanami A, Aoki S, Ohtomo K, Kato N, Kato T. 1H-MR spectroscopy and gray matter volume of
the anterior cingulate cortex in schizophrenia. Neuroreport. 13: 2133-2137, 2002.

Review Articles
Yamasue H*, Yee JR, Hurlemann R, Rilling JK, Chen FS, Meyer-Lindenberg A, Tost H.
Integrative approaches utilizing oxytocin to enhance prosocial behavior: from animal and humansocial behavior to autistic social dysfunction. The Jounal of Neuroscience. 32: 14109-14117,2012.
Yamasue H*, Kuwabara H, Kawakubo Y, Kasai K. Oxytocin, sexually dimorphic features of thesocial brain, and autism. Psychiatry and Clinical Neurosciences. 63: 129-140, 2009.

Prizes:Young Investigator Award, Japan Neuroscience Society, June 2013.
The first prize, Research group for schizophrenia 2011
Silver prize, 21th century COE program, University of Tokyo, 2004
Award for Young Investigator, Japanese Society of Biological Psychiatry 2003

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