Curriculum Vitae

1/2015

ShubhaTole
Department of Biological Sciences
Tata Institute of Fundamental Research
Mumbai-400,005, India
email: shubhatole@gmail.com
Date of Birth: 31/08/1967
Current Appointment:
Professor

Department of Biological Sciences
Tata Institute of Fundamental Research, India

2011-present

Previous Appointments:
Visiting Professor
Visiting Associate Professor
Associate Professor
Reader
Fellow
Post Doctoral Fellow

University of Geneva
Stanford University
Tata Institute of Fundamental Research, India
Tata Institute of Fundamental Research, India
Tata Institute of Fundamental Research, India
University of Chicago

2014
2008-20092007-2011
2002-2007
1999-2002
1994-1999

Education:
Ph DMSBScCalifornia Institute of Technology
California Institute of Technology
St. Xavier's College, University of Bombay

1994
1991
1987

Awards, Honours, and Grants:
1. The Infosys Prize in Life Sciences(http://www.infosys-science-foundation.com/prize/index.asp)

2014

2. The 1st Swati Maiti memorial seminar, IISc, Bangalore2013

3. K. T. Shetty memorial oration,
Indian Academy of Neurosciences

2011

4. The S. S. Bhatnagar Award in Biological Sciences(India’s highest scientific honor: http://ssbprize.gov.in/ )2010

5. Research Award for Innovation in Neuroscience (RAIN award)
Society for Neuroscience, USA

2008

6. Wellcome Trust Flexible Travel Award
For a Sabbatical year at Stanford University, USA

2008-2009

7. National Woman Bioscientist award
Dept. Biotechnology, Govt. of India

2008

8. The Swarnajayanti Fellowship (Govt. of India)
India’s “Golden Jubilee” award for young scientists

2005-20101

9. The Wellcome Trust Senior Research Fellowship

1999-2006

10. AMBO International Training Fellowship2000

11. Scholarship Award
Women's Council of the Brain Research Foundation, Chicago

1995, '97, '99

12. International Fellowship
American Association of University Women

1996

Memberships:
Member, Ethics Committee of the Soc. for Neuroscience
2014-present
Member, Scientific Publications Committee of the Soc. for Neuroscience
2012-2015
Member, F1000
2012-present
Member, F1000 Research Editorial Board
2012-present
Member,Asia Pacific Regional Committee (APRC) of the
2011-present
IBRO (International Brain Research Organization)
Fellow, National Academy of Sciences, India
2010-present(Council Member 2012-2015)
Fellow, Indian Academy of Sciences, India
2010-present
Member, International Affairs Committee, American Society for Cell Biology 2009- present
Member, Society for Neuroscience, USA
1991-present
Current Lab members:
Post Doctoral Fellows:
Dr. Disha Chauhan
Dr. Swetha Godavarthi
Dr. Mallika Chatterjee (Wellcome Trust-DBT India Alliance Early Career Fellow 2013)
Dr. Geeta Godbole(Wellcome Trust-DBT India Alliance Early Career Fellow2012)
Dr. M. Bhavana(Wellcome Trust-DBT India Alliance Early Career Fellow 2011)
PhD students:

Veena Kinare (collaborative student with Prof. Rajadhyaksha, Sophia College)
Suranjana Pal

MSc students:

Zeba Khatri
Basabdatta Roy
Ritika Gupta

Post Doctoral researchers supervised in previous years (came from; current position)
Dr. Nandini Gokulchandran(MD-Nagpur Medical College;
Research Scientist, Neurogen, Mumbai)
Dr. Vishakha Mangale(PhD- NIRR, Mumbai; Research Scientist, GE Healthcare, Banglore)
Dr. Alfredo Socorro(PhD- ULL, Spain; Post doc with Gundela Meyer, ULL, Spain)
Dr. Ben Martynoga(PhD- U. Edinburgh, UK; Post doc with Francois Guillemot, MRC, UK)

2

Students Graduated from the Tole lab (current position)
PhD
PhD
PhD
PhD
PhD
PhD
PhD

Bhaskar Saha
(PhD 2006; Faculty at St. Xavier’s College, Mumbai)
Hari Padmanabhan(PhD 2008; postdoc with Jeff Macklis, Harvard Medical School)
Lakshmi Subramanian (PhD 2008; postdoc with Arnold Kreigstein, UCSF)
Anindita Sarkar(PhD 2012; postdoc with Fred Gage, Salk Institute)
Dhananjay Huilgol(PhD 2012; postdoc with Josh Huang, CSHL)
Achira Roy(PhD 2013; postdoc with Kathy Millen, U. Washington)
Ashwin Shetty(PhD 2013; postdoc with Paola Arlotta, Harvard University)

MSc:

Upasana Maheshwari
Dhananjay Chaturvedi
R.V. Satyaki
Aditi Falnikar
Mugdha Deshpande
Ryan Remedios
Vanisha Lakhina(MSc 2014; Phd Student at FMI, Basel, Switzerland)(MSc 2008; PhD student at U. Texas, Dallas)(MSc 2007; PhD student in Cornell University)(MSc 2006; PhD student in Drexel University)(MSc 2006; PhD student in U. Texas, Austin)(MSc 2005; PhD MPI, Tuebingen; postdoc with David Anderson, Caltech)(MSc 2004; PhD student in University of Pennsylvania;
postdoc Princeton University)
Lakshm i Subramanian (MSc 2004; PhD 2008, TIFR; currently post doc at UCSF)
Aditee Vyas
(MSc 2002; PhD 2006, IGBMC, France
Currently Research Scientist at Nicholas Piramal, Mumbai)
Sarada Bulchand(MSc 2002; PhD and postdoc TLL, Singapore;
Currently Scientific Communications Officer, TIFR, Mumbai)

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Publications#corresponding author

1. Shetty AS, Godbole G, Maheshawari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo H-C, V Rema, Tole S# (2013) Lhx2 regulates a cortex-specific mechanism forbarrel formation
PNASdoi:10.1073/pnas.1311158110
2. Roy A, De MeloJ,Chaturvedi D, Thien T, Cabrera-Soccoro A, Houart C, Meyer G,BlackshawS,Tole S# (2013) Lhx2 is necessary for themaintenance of optic identity andprogression of optic morphogenesis
Journal of Neuroscience33(16):6877-84
3. Huilgol D, Udin, S, Shimogori T, Saha B, Roy A, Aizawa S., Hevner RF, Meyer G., Ohshima T,Pleasure SJ, Zhao Y, Tole S# (2013)Dual origins of the mammalian accessory olfactory bulb
revealed by an evolutionarily conserved migratory streamNature Neuroscience 16(2):157-65
4. Roy A, GonzalezM,PieraniA, Meyer G,Tole S# (2013) Lhx2 regulates the development of theforebrain hem system
Cerebral Cortex10.1093/cercor/bhs421
5. Falnikar A, Tole S, Liu M, Liu JS, and Baas PW.Polarity in migrating neurons is related to amechanism analogous to cytokinesis (2013)
Current Biology 23(13):1215-20
6. Harel I, Maezawa Y, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross J, Leviatan N, Hegesh JT,Roy A, Jacob J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E. (2012)
Pharyngeal Mesoderm Regulatory Network Controls Cardiac and Head Muscle Morphogenesis
PNAS109(46):18839-44
7. Marcos-Mondéjar P, Peregrín S, Li JY, Carlsson L, Tole S, López-Bendito, G. The Lhx2
Transcription Factor Controls Thalamocortical Axonal Guidance by Specific Regulation of Robo1
and Robo2 Receptors. (2012)
Journal of Neuroscience, 32:4372-4385
8. Subramanian L, Sarkar A, Ashwin S, Muralidharan B, Hari P, Piper M, Monuki ES, BachI,Gronostajski R, Richards R, andTole, S# (2011)Transcription factor Lhx2is necessary andsufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.
PNASwww.pnas.org/cgi/doi/10.1073/pnas.1101109108
9. Desouza LA, Sathanoori M, Kapoor R, Rajadhyaksha N, Gonzalez LE, Kottmann AH, ToleS,
Vaidya VA. (2011) Thyroid hormone regulates the expression of the sonic hedgehog signaling
pathway in the embryonic and adult Mammalian brain Endocrinology 152(5):1989-2000.
10. Falnikar A, Tole S, Baas PW. (2011)Kinesin-5, mitotic microtubule-associated motor protein,modulates neuronal migration
MolBiol Cell22(9):1561-74.

11. Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, SarkarA,Smith AG, Moldrich RX,
Boyle GM,Tole S, GronostajskiRM, Bailey TL, and Richards LJ. NFIA Controls Telencephalic
Progenitor Cell Differentiation through Repression of the Notch Effector Hes1. (2010)
J. Neuroscience30:9127–9139

412. Mangale VS, Hirokawa KE, Satyaki PRV, GokulchandranN, ChikbireS, Subramanian L, Shetty AS,Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S#, and Monuki ES # (2008) Lhx2 selector
activity specifies cortical identity and suppresses hippocampal organizer fate Science319: 304309# co-corresponding authors“Perspectives” based on this paper: E. A. Grove “Organizing the Source of Memory”
Science (319) 288-289
A highlight based on this paper: M. H. Flight “Instructions for the Hippocampus”
Nature Reviews Neuroscience 9 (3): 164-165
13. Hari P, Deshpande M, Sharma N, Rajyadhaksha N, Ramkumar N, Kimura, K., Rodrigues V#,
Tole S#.(2008) Chip is required for post-eclosionbehaviour in Drosophila.
J. Neuroscience28:9145-50.# co- corresponding authors
14. Barry G, Piper M, Lindwall C, Moldrich R, Mason S, Little E, Sarkar A, Tole S, Gronostajski RM,Richards LJ. (2008)Specific glial populations regulate hippocampal morphogenesis.
Journal of Neuroscience. (28):12328-40.
15. Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk T., Hevner R. F., Suda Y.,
Aizawa S., Ohshima, T., Stoykova, A., Tole, S#. (2007) A novel stream of amygdaloid cells fromthe caudal telencephalon reveals a developmental link between the amygdala and the neocortex
Nature Neuroscience 10 (9): 1141–1150“News and Views” based on this paper: J. M. Deussing and W. Wurst “Amygdala andNeocortex: Common Origins and Shared Mechanisms” Nature Neuroscience 10 (9): 10811082
16. Saha, B. Hari P., Huilgol, D. and Tole, S#. (2007) Dual role for LIM-HD gene Lhx2 in theformation of the lateral olfactory tract (LOT)
Journal of Neuroscience 27: 2290-2297
17. Lakhina, V., Falnikar, A., Bhatnagar, L., Tole, S#. (2007)Earlythalamocortical tract guidance andtopographic sorting of thalamic projections requires LIM- homeodomain gene Lhx2
Developmental Biology306(2) 703-713.
18. Tole, S.#,Gutin, G., Bhatnagar, L., Remedios, R, Hebert, J. #(2006) Development of midline celltypes and commissural axon tracts requires Fgfr1 in the cerebrum. Developmental Biology, 289:
141 – 151# co-corresponding authors
19. Tole, S. #,Remedios, R., Saha, B., Stoykova, A. #(2005) Differential roles of Pax6 and Emx2 in thedevelopment of the amygdaloid complex.
Journal of Neuroscience, 25(10):2753–2760.
# co-corresponding authors
20. Banerjee, S. B., Rajendran, R., Dias, B. G., Ladiwala, U., Tole, S., Vaidya, V. A. (2005)
Recruitment of the Sonic Hedgehog signaling cascade in electroconvulsive seizure mediatedregulation of adult hippocampal neurogenesis. European Journal of Neuroscience, 22: 1570-80
21. Remedios, R., Subramanian, L., Tole S#. (2004) LIM genes parcellate the embryonic amygdalaand regulate its development.
Journal of Neuroscience, 24(31):6986-6990.
22. Vyas, A., Saha, B., Lai, E., Tole, S#. (2003) The Paleocortex is specified in mice in which
dorsaltelencephalic patterning is severely disrupted. Journal of Comparative Neurology,
466:545-553

523. Oh, L.Y.S., Denninger, J. S., Colvin, J., Vyas, A., Tole, S. Ornitz, D. M., and Bansal, R. (2003)
Fibroblast Growth Receptor-3 signaling regulates the onset of oligodendrocyte terminal
differentiation. Journal of Neuroscience23(3): 883-894
24. Bansal, R.#, Lakhina,V., RemediosR., Tole, S.#(2003) Expression of FGF Receptors 1, 2, and 3 in
the Embryonic And Postnatal Mouse Brain compared with Pdgfra, Olig2, and PLP/DM20:
Implications for Oligodendrocyte Development. Developmental Neuroscience, 25: 83-95.
#
co-corresponding authors
25. Bulchand, S., Subramanian, L., and Tole, S#. (2003) Dynamic spatio-temporal expression of LIM
genes and co-factors in the embryonic and postnatal cerebral cortex. Developmental Dynamics,
226(3):460-469.
26. Bulchand, S., Grove, E. A., Porter, F. D., and Tole, S. (2001)#. LIM-homeodomain gene Lhx2
regulates the formation of the cortical hem. Mechanisms of Development, 100(2) 165-175.
The publications above represent work from Dr. Tole’s lab at TIFR------------------------------------------------------------------------------------------------------------The publications below represent work during Dr. Tole’s PhD and post doc
27. Tole, S. and Grove, E. A. (2001) Detailed field pattern is intrinsic to the embryonic mouse
hippocampus early in neurogenesis. Journal of Neuroscience, 21(5): 1580-1589.
28. Tole, S. Goudreau, G., Assimacopoulous, S. and Grove E.A. (2000). Emx2 is required for thegrowth of the hippocampus but not for hippocampal field specification. Journal of Neuroscience20(7) 2618-2625.
29. Tole, S., Ragsdale, C. W., and Grove, E. A. (2000). Dorsoventral patterning of the telencephalon
is disrupted in the mouse mutant extra-toesJ. Developmental Biology 217 (2) 254-265.
30. Lee, S. M. K., Tole, S., Grove, E. A., and McMahon, A. P. (2000)A local Wnt-3a signal is requiredfor development of the mammalian hippocampus. Development 127 (3) 457-467.
31. Grove, E. A. andTole, S. (1999). Patterning events and specification signals in the developinghippocampus. Cerebral Cortex 9 (6) 551-561.
32. Grove, E. A., Tole, S., Limon J., Yip, L-W., and Ragsdale, C. W. (1998). The hem of theembryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromisedin Gli3-deficient mice. Development. 125 (12) 2315-2325.
33. Tole, S.,Christian,C. and Grove, E. A. (1997). Early specification and autonomous developmentof cortical fields in the mouse hippocampus. Development. 124 (24) 4959-4970.
34. Tole, S., Kaprielian, Z., Ou, S., Patterson, P. H. (1995) FORSE-1: A positionally-regulated epitopein the developing rat central nervous system. Journal of Neuroscience 15: 957-969.
35. Tole, S., and Patterson, P. H. Regionalization of the developing forebrain: a comparative study ofFORSE-1, Dlx-2 and BF-1. (1995) Journal of Neuroscience 15: 970-980.
36. Tole, S., and Patterson, P.H. (1993). Distribution of CD9 in the developing and mature rat nervoussystem. Developmental Dynamics 197:94-106.

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Reviews
1. Chatterjee M, HuilgolD,Tole S#. Building the Body, Building the Brain (2012)Journal of theIndian Institute of Science 92 (4): 369-376
2. Subramanian L, and Tole S#.(2009) Mechanisms underlying the specification, positional
regulation and function of the cortical hem.Cerebral Cortex19 (Suppl 1):i90-5.
3. Subramanian L, Remedios, R, Shetty, AS, and Tole S#. (2009) Signals from the Edges: The
Cortical Hem and Antihem in telencephalic development. Seminars in Cell andDevelopmental Biology 20(6):712-8
4. Subramanian, L., Lakhina, V., Padmanabhan, H., and Tole, S#. (2003) Specification of cell
identity in development: Role of LIM genes. Proc. Indian Natl. Sci. Acad. B69 5: 805-826.

Editorial:
1. Tole S. and Vale, R. (2010). Young leaders for Biology in India. Science 329: 1441.
(Editorial)

Book Chapter:
1. Tole S. and Hebert J. Telencephalon Patterning. “Cellular Migration and Formation of
Neuronal Connections: Comprehensive Developmental Neuroscience” (2013) John Rubenstein andPaskoRakic (Eds). Academic Press. ISBN: 978-0-12-397265-1

F1000 Recommendations
Shetty AS and Tole S http://f1000.com/717952889
Shetty AS and Tole S http://f1000.com/prime/14264140
Tole S and Huilgol D http://f1000.com/prime/718122719
Blogs:
Scientist and Mommy http://www.indiabioscience.org/article/shubha-tole
How to choose which institution or which lab to join? http://www.indiabioscience.org/node/778
One possible plug for the leaky pipeline http://www.indiabioscience.org/node/327
Are we doing enough?http://www.indiabioscience.org/node/245
How are we viewing collaborations? http://www.indiabioscience.org/node/166
Advice for students starting out in research http://www.indiabioscience.org/node/159
Taking the “ME” out of Mentorship http://www.indiabioscience.org/node/9768

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