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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
Date of issue for the 1st edition : 14/Jan/2014
Date of revision : 18/Nov/2022

Safety Data Sheet

Section 1. Identification of the substance/mixture and of the company/undertaking
Product identifier:Product name: Toluene
Reference number(SDS):50070jis_J_E1-3
Product type：
Reagent
Details of the supplier of the safety data sheet
Manufacturer/Supplier: JUNSEI CHEMICAL CO., LTD.
Address: 1-6, Ohmano-cho, Koshigaya-shi, Saitama 343-0844, Japan
Division: Quality Assurance Department
Telephone number: +81-48-986-6161
FAX: +81-48-989-2787
e-mail address: shiyaku-t@junsei.co.jp

Section 2. Hazards identification
GHS classification and label elements of the product
Classification of the substance or mixture
PHYSICAL AND CHEMICAL HAZARDS
Flammable liquids: Category 2
HEALTH HAZARDS
Acute toxicity (Inhalation): Category 4
Skin corrosion/irritation: Category 2
Serious eye damage/eye irritation: Category 2B
Reproductive toxicity: Category 1A
Reproductive toxicity - effects on or via lactation: Additional category
Specific target organ toxicity - single exposure: Category 1(central nervous system)
Specific target organ toxicity - single exposure: Category 3 (Respiratory tract irritation)
Specific target organ toxicity - single exposure: Category 3 (Narcosis)
Specific target organ toxicity - repeated exposure: Category 1(central nervous system, kidney)
Aspiration hazard: Category 1
ENVIRONMENT HAZARDS
Hazardous to the aquatic environment (Acute): Category 2
Hazardous to the aquatic environment (Long-term): Category 3(Note) GHS classification without description: Not classified/Classification not possible
Label elements

Signal word: Danger
HAZARD STATEMENT
H225-Highly flammable liquid and vapor
H332-Harmful if inhaled
H315-Causes skin irritation
H320-Causes eye irritation
H360-May damage fertility or the unborn childH362-May cause harm to breast-fed children
H370-Causes damage to organs

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
H335-May cause respiratory irritation
H336-May cause drowsiness or dizzinessH372-Causes damage to organs through prolonged or repeated exposure
H304-May be fatal if swallowed and enters airways
H401-Toxic to aquatic life
H412-Harmful to aquatic life with long lasting effects
PRECAUTIONARY STATEMENT
Prevention
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Avoid contact during pregnancy and while nursing.
Avoid release to the environment.
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Keep container tightly closed.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
Do not breathe vapors.
Use only outdoors or in a well-ventilated area.
Wash contaminated parts thoroughly after handling.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
Do not eat, drink or smoke when using this product.
Response
In case of fire: Use foam, dry powder, CO2 to extinguish.
Get medical advice/attention if you feel unwell.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF exposed or concerned: Call a POISON CENTER/doctor/physician.
IF INHALED: Remove person to fresh air and keep comfortable for breathing.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Do NOT induce vomiting. Immediately call a POISON CENTER/doctor/physician.
Storage
Store in a well-ventilated place. Keep container tightly closed. Keep cool.
Store locked up.
Disposal
Dispose of contents/container in accordance with local/national regulation.
Specific Physical and Chemical hazards
Highly flammable liquid. Vapor/air mixture may explode.

Section 3. Composition/information on ingredients
Mixture/Substance selection:
Substance
Ingredient name:Toluene
Content (%):99.0 <Chemical formula:C7H8

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
Chemicals No, Japan:3-2
CAS No.:108-88-3
MW:92.14
ECNO:203-625-9
Note : The figures shown above are not the specifications of the product.

Section 4. First-aid measures
Descriptions of first-aid measures
General measures
Get medical advice/attention if you feel unwell.
Keep victim warm and quiet.
Call emergency medical service.
Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
IF INHALED
Remove person to fresh air and keep comfortable for breathing.
Give artificial respiration if victim is not breathing.
Administer oxygen if breathing is difficult.
Call a POISON CENTER/doctor/physician if you feel unwell.
IF ON SKIN (or hair）
Take off immediately all contaminated clothing. Rinse skin with water or shower.
Wash with plenty of soap and water.
If skin irritation or rash occurs: Get medical advice/attention.
If skin irritation occurs: Get medical advice/attention.
In case of burns, immediately cool affected skin for as long as possible with cｈild water.
Do not remove clothing if adhering to skin.
Remove and isolate contaminated clothing and shoes.
IF IN EYES
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED
Rinse mouth. Do NOT induce vomiting.
Immediately call a POISON CENTER/doctor/physician.
Call a POISON CENTER/doctor/physician if you feel unwell.
Most important symptoms and effects, both acute and delayed(Symptoms when inhalation or ingestion)
Nausea. Abdominal pain. Headache. Drowsiness. Cough. Dizziness. Sore throat. Unconsciousness.
Burning sensation.
(Symptoms when skin and/or eye contact)
Dry skin. Conjunctival redness of the eyes. Redness of the skin. Pain of the eyes.

Section 5. Fire-fighting measures
Extinguishing media
Suitable extinguishing media
In case of fire, use foam, dry powder, CO2 to extinguish.
Unsuitable extinguishing media
Do not use direct water jet.
Water may be effective for cooling, but may not effect extinguishment.
Specific hazards arising from the substance or mixture
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may cause pollution.

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
Advice for firefighters
Specific fire-fighting measures
Evacuate non-essential personnel to safe area.
Cool container with water spray.
Special protective equipment and precautions for fire-fighters
Wear fire resistant or flame retardant clothing.
Wear protective gloves/protective clothing/eye protection/face protection.
Firefighters should wear self-contained breathing apparatus with full face peace operated
positive pressure mode.

Section 6. Accidental release measures
Personnel precautions, protective equipment and emergency procedures
Keep unauthorized personnel away.
In case of contact with substance, immediately flush skin or eyes with running water for atleast 20 minutes.
Ventilate area until material pick up is complete.
Wear proper protective equipment.
PUBLIC SAFTY: Ventilate closed spaces before entering.
Do not touch or walk through spilled material.
Environmental precautions
Runoff to sewer may create fire or explosion hazard.
Vapor explosion hazard indoors, outdoors or in sewers.
Avoid release to headsprings, rivers, lakes, ocean and groundwater.
Methods and materials for containment and cleaning up
Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean non-sparking tools to collect absorbed material.
All equipment used when handling the product must be grounded.
Preventive measures for secondary accident
Collect spillage.
Stop leak if you can do it without risk.
ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area).
Prevent entry into waterways, sewers, basements or confined areas.
Keep out of low areas.

Section 7. Handling and storage
Precautions for safe handling
Preventive measures(Exposure Control for handling personnel)
Do not breathe vapors/fume.
(Protective measures against fire and explosion)
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
Ground and bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting equipment.
Use non-sparking tools.
Take action to prevent static discharges.
(Exhaust/ventilator)
Exhaust/ventilator should be available.
(Safety treatments)
Avoid contact with skin.
Avoid contact with eyes.
Safety Measures
Obtain special instructions before use.

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
Do not handle until all safety precautions have been read and understood.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
When using do not eat, drink or smoke.
Any incompatibilities
Strong oxidizing agents should not be mixed with the chemicals.
Advice on general occupational hygiene
Avoid contact during pregnancy and while nursing.
Wash contaminated parts thoroughly after handling.
Do not eat, drink or smoke when using this product.
Take off contaminated clothing and wash it before reuse.
Storage
Conditions for safe storage
Store in a well-ventilated place. Keep container tightly closed.
Keep cool. Protect from sunlight.
Store in accordance with local/national regulation.
Store locked up.
Container and packaging materials for safe handling data is not available.
Specific end use(s)See information in Section 7.1 and 7.2 for handling and storage recommendations. See
Section 8 for exposure controls and personal protection recommendations.

Section 8. Exposure controls/personal protection
Control parameters
Control value
Japan control value (2009) <= 20ppm
Adopted value
JSOH(2013) 50ppm; 188mg/m3 (dermal)
ACGIH(2020) TWA: 20ppm (CNS, visual, & hearing impair; female repro system eff; pregnancy loss)
Notation…OTO
Exposure controls
Appropriate engineering controls
Do not use in areas without adequate ventilation.
Eye wash station should be available.
Washing facilities should be available.
Individual protection measures
Respiratory protection
Wear respiratory protection.
Wear positive pressure self-contained breathing apparatus (SCBA).
Hand protection
Wear protective gloves. Recommended material(s): viton
Inspect before use and replace worn or damaged gloves.
Contact the glove manufacturer for specific advice on glove selection and breakthroughtimes for your use conditions.
Eye protection
Wear safety glasses with side-shields.
Wear eye/face protection.
Skin and body protection
Wear impervious clothing and boots in case of repeated or prolonged treatment.

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
Section 9. Physical and Chemical Properties
Information on basic physical and chemical properties
Physical state: Liquid
Color: Colorless
Odor: Characteristic odor
Odor threshold: 2.14 ppm (8 mg/m3)
Melting point/Freezing point: -95℃
Boiling point or initial boiling point: 111℃
Boiling range data is not available.
Flammability (gases, liquids and solids): Ignitable
Lower and upper explosion limit/flammability limit:
Lower explosion limit: 1.1 vol %Upper explosion limit: 7.1 vol %Flash point: (C.C.) 4℃
Auto-ignition temperature: 480℃
Decomposition temperature data is not available.
Self-Accelerating Decomposition Temperature/SADT data is not available.
pH data is not available.
Dynamic viscosity: 0.727mPas(40℃)
Kinematic viscosity: 0.86 mm2/s (40℃)
Solubility:
Solubility in water: 526 mg/L (25℃)
Solubility in solvent: Very soluble in ethanol and diethyl ether.
n-Octanol/water partition coefficient: log Pow2.73
Vapor pressure: 3.8 kPa (25℃)
Density and/or relative density: 0.87g/cm3(20℃)
Relative vapor density (Air=1): 3.1
Relative density of the Vapor/air - mixture at 20℃ (Air = 1): 1.01
Particle characteristics data is not available.
Other information
Critical temperature: 591.75K
Evaporation rate data is not available.
VOC data is not available.

Section 10. Stability and Reactivity
Reactivity
Runaway polymerization will not occur.
Chemical stability
Stable under normal storage/handling conditions.
Highly flammable.
Possibility of hazardous reactions
The vapour mixes well with air, explosive mixtures are easily formed.
As a result of flow, agitation, etc., electrostatic charges can be generated.
Reacts violently with strong oxidants. This generates fire and explosion hazard.
Conditions to avoid
Contact with incompatible materials.
Open flames. Heating. Sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Carbon oxides

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Section 11. Toxicological Information
Information on toxicological effects
Acute toxicity
Acute toxicity (Oral)[Product]
Based on available data, the classification criteria are not met.
[Data for components of the product][GHS Cat. Japan, base data]
rat LD50=5000 mg/kg（MOE risk assessment vol. 1, 2002）
Acute toxicity (Dermal)[Product]
Based on available data, the classification criteria are not met.
[Data for components of the product][GHS Cat. Japan, base data]
rabbit LD50=12400 mg/kg（EU-RAR, 2003）
Acute toxicity (Inhalation)[Product]Category 4, Harmful if inhaled[Data for components of the product][GHS Cat. Japan, base data]
vapor: rat LC50=3319～8800ppm/4hr (EU-RAR, 2003 et al.)Labor standard law, Japan; Toxic
Toluene
Irritant properties
Skin corrosion/irritation[Product]Category 2, Causes skin irritation[Data for components of the product][GHS Cat. Japan, base data]
rabbit : moderate irritation (EU-RAR, 2003)
Serious eye damage/irritation[Product]Category 2B, Causes eye irritation[Data for components of the product][GHS Cat. Japan, base data]
rabbit : slight eyes irritation (EU-RAR, 2003)
Sensitization
Respiratory sensitization[Product]Classification not possible (Insufficient data available or no data available).
[Data for components of the product]
No data available.
Skin sensitization[Product]
Based on available data, the classification criteria are not met.
[Data for components of the product][GHS Cat. Japan, base data]
guinea pigs (EU guideline B6, GLP) : it was concluded that this substance was not a skin sensitizer.
(EU-RAR, 2003)
Germ cell mutagenicity[Product]
Based on available data, the classification criteria are not met.

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022[Data for components of the product]
Mutagen [MHLW_J Notice][GHS Cat. Japan, base data]mice(in vivo germ cell mutagenicity test) : All negative (NITE risk assessment No. 87, 2006)
mice or rats(in vivo somatic cell mutagenicity test) : All negative(NITE risk assessment No.87, 2006 et al.)
Reverse-mutation assay in bacteria (Ames test) : Negative(NITE risk assessment No. 87, 2006 et al.)
Chromosome aberration test (CHO cells) : Negative (NITE risk assessment No. 87, 2006)
Carcinogenicity[Product]Classification not possible (Insufficient data available or no data available).
[Product data]
No data available.
[Data for components of the product][IARC]
Group 3 : Not classifiable as to its carcinogenicity to humans[ACGIH]
A4(2020) : Not Classifiable as a Human Carcinogen[EPA]
I; Inadequate information to assess carcinogenic potential(2005)
Reproductive toxicity[Product]Category 1A, May damage fertility or the unborn child
Additional category, May cause harm to breast-fed children[Data for components of the product][GHS Cat. Japan, base data]
cat. 1A; NITE Initial Risk Assessment Report 87, 2006
cat. add; SIDS(J), Access on Apr. 2012
Specific target organ toxicity (STOT)
STOT-single exposure[Product]Category 1, Causes damage to organs
Category 3, May cause respiratory irritation
Category 3, May cause drowsiness or dizziness[Data for components of the product][cat.1][GHS Cat. Japan, base data]
central nervous system (IARC 47, 1989; IRIS tox. Review, 2005)[cat.3 (resp. irrit.)][GHS Cat. Japan, base data](Toluene)
respiratory tract irritation (PATTY 5th, 2001)[cat.3 (drow./dizz.)][GHS Cat. Japan, base data]narcotic effect (EHC 52, 1985; IARC 47, 1989)
STOT-repeated exposure[Product]Category 1, Causes damage to organs through prolonged or repeated exposure[Data for components of the product][cat.1][GHS Cat. Japan, base data]
central nervous system, kidneys (Occupational medicine vol.36, 1994)
Aspiration hazard[Product]Category 1, May be fatal if swallowed and enters airways

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022[Data for components of the product][cat.1][GHS Cat. Japan, base data]
cat. 1; hydrocarbon, kinematic viscosity =0.86 mm2/s (40℃)

Section 12. Ecological Information
Toxicity
Aquatic toxicity[Product]Category 2, Toxic to aquatic life
Category 3, Harmful to aquatic life with long lasting effects[Data for components of the product]
Hazardous to the aquatic environment (Acute)[GHS Cat. Japan, base data]
Crustacea (Ceriodaphnia dubia) EC50=3.78mg/L/48hr (NITE Initial Risk Assessment Report, 2006)
Hazardous to the aquatic environment (Long-term)[GHS Cat. Japan, base data]
Crustacea (Ceriodaphnia dubia) NOEC=0.74mg/L/7days (NITE Initial Risk Assessment Report, 2006)
Water solubility[Data for components of the product]
526 mg/L (25℃) (HSDB)
Persistence and degradability[Data for components of the product]
BOD_Degradation : 123% (METI existing chemical safety inspections in Japan)
Bioaccumulative potential[Data for components of the product]log Pow=2.73 (PHYSPROP DB, 2008)
Mobility in soil
Mobility in soil data is not available.
Other adverse effects
Ozone depleting chemical data is not available.

Section 13. Disposal considerations
Description of waste residues and information on their safe handling and methods of disposal,
including the disposal of any contaminated packaging
Waste treatment methods
Avoid release to the environment.
Dispose of contents/container in accordance with local/national regulation.

Section 14. Transport Information
UN No., UN CLASSUN No. or ID No.: 1294
UN Proper Shipping Name : TOLUENE
Class or division (Transport hazard class) : 3
Packing group : II
ERG GUIDE No.: 130
IMDG Code (International Maritime Dangerous Goods Regulations)
UN No.: 1294
Proper Shipping Name : TOLUENE
Class or division : 3
Packing group : II

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Toluene,JUNSEI CHEMICAL CO., LTD.,50070jis_J_E1-3,18/Nov/2022
IATA Dangerous Goods Regulations
UN No.: 1294
Proper Shipping Name : TOLUENE
Class or division : 3
Hazard labels : Flamm.liquid
Packing group : II
Environmental hazards
MARPOL Annex III - Prevention of pollution by harmful substances
Marine pollutants (yes/no) : no
MARPOL Annex V - Prevention of pollution by garbage discharge
Reproductive toxicity: cat.1, 1A, 1B
TolueneSpecific target organ toxicity - repeated exposure: cat.1
TolueneMaritime transport in bulk according to IMO instruments
Noxious Liquid ; Cat. Y
Toluene(Y-299)
Flammable Liquid
Toluene(DANGEROUS-15)

Section 15. Regulatory Information
Safety, health and environmental regulations/legislation specific for the substance or mixture
U.S. Toxic Substances Control Act (TSCA) Inventory
Chemicals listed in TSCA Inventory
108-88-3
All components are listed or exempted.
Superfund Amendments and Reauthorizations Act (SARA), Title III
SARA 313 (TRI)
TolueneOther regulatory information
We are not able to check up the regulatory information with regard to the substances inyour country or region, therefore, we request this matter would be filled by your responsibility.
Regulatory information with regard to this substance in your country or in your region
should be examined by your own responsibility.
Ensure this material in compliance with federal requirements and ensure conformity to local regulations.
Regulatory information in this section are limited to intentional ingredient(s), but does
not contain information on non-intentional ingredients or impurities which are not informed by supplier(s).
Chemical safety assessment
Advice on safe handling for this product can be found in sections 7 and 8 of this SDS.

Section 16. Other information
GHS classification and labelling
H225-Flammable liquids, Category 2: H225 Highly flammable liquid and vapour
H332-Acute toxicity, Category 4: H332 Harmful if inhaled
H315-Skin corrosion/irritation, Category 2: H315 Causes skin irritation
H320-Serious eye damage/eye irritation, Category 2B: H320 Causes eye irritation
H360-Reproductive toxicity, Category 1A: H360 May damage fertility or the unborn childH362-Reproductive toxicity - effects on or via lactation, Additional category : H362 May
cause harm to breast-fed children
H370-STOT - single exposure, Category 1: H370 Causes damage to organs
H335-STOT - single exposure, Category 3, Respiratory tract irritation: H335 May cause
respiratory irritation.

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H336-STOT - single exposure, Category 3, Respiratory tract irritation: H336 May cause
drowsiness or dizziness.
H372-STOT - Repeated exposure, Category 1: H372 Causes damage to organs through prolonged
or repeated exposure
H304-Aspiration hazard, Category 1: H304 May be fatal if swallowed and enters airways
H401-Hazardous to the aquatic environment, short-term (acute), Category 2: H401 Toxic to aquatic life
H412-Hazardous to the aquatic environment, long-term (chronic), Category 3: H412 Harmful toaquatic life with long lasting effects
References and sources for data
Globally Harmonized System of classification and labelling of chemicals, UN
Recommendations on the TRANSPORT OF DANGEROUS GOODS 21th edit., 2019 UN
IMDG Code, 2018 Edition (Incorporating Amendment 39-18)
IATA Dangerous Goods Regulations (62nd Edition) 2021
2020 EMERGENCY RESPONSE GUIDEBOOK (US DOT)
2022 TLVs and BEIs. (ACGIH)
JIS Z 7252 : 2019
JIS Z 7253 : 20192021 Recommendation on TLVs (JSOH)
Supplier's data/information
Chemicals safety data management system "GHS Assistant" Version 4.19 (https://www.asahi-ghs.com/)
NITE Chemical Risk Information Platform "NITE-CHRIP"(https://www.nite.go.jp/en/chem/chrip/chrip_search/systemTop)
GHS Classification Guidance for Enterprises 2019 Revised Edition (Ver. 2.0) （Mar. 2020, METI)
Abbreviations and acronyms
SDS (Safety Data Sheet)
LD50 (Lethal Dose, 50％)
LC50 (Lethal Concentration, 50％)
IARC (International Agency for Research on Cancer)
ACGIH (American Conference of Governmental Industrial Hygienists)
EPA (US Environmental Protection Agency)
NTP (US National Toxicology Program)
JSOH (Japan Society for Occupational Health)EU (European Union)
EC50 (Effective Concentration, 50％)
NOEC (No Observed Effect Concentration)
BOD (Biochemical Oxygen Demand)
COD (Chemical Oxygen Demand)
BCF (Bioconcentration Factor)anh (anhydride)
General Disclaimer
This data sheet was created based on the information we currently have and may be revised
according to new information. In addition, the precautions apply only to normal handling,
and in the case of special handling, please make adequate countermeasure to maintain yoursafety.
The data given here is based on current knowledge and experience. The purpose of this
Safety Data Sheet is to describe the products in terms of their safety requirements. The
data does not signify any warranty with regard to the products' properties.
The GHS classification data given here is based on current Japan official data (NITE
published in 2021).